Resolution of Oral Hairy Leukoplakia During Therapy with 9-(1,3-dihydroxy-2-propoxymethyl) guanine (DHPG)
Authors: Cheryl Newman, B. Frank Polk
Journal: Annals of Internal Medicine (1987)

Brief Reports1 September 1987Resolution of Oral Hairy Leukoplakia During Therapy with 9-(1,3-dihydroxy-2-propoxymethyl) guanine (DHPG)CHERYL NEWMAN, M.D., B. FRANK POLK, M.D.CHERYL NEWMAN, M.D.Search for more papers by this author, B. FRANK POLK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-2-348 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVarious oral lesions have been associated with human immunodeficiency virus (HIV) infection. Oral candidiasis is the most commonly recognized infectious process involving the oral cavity, and Kaposi sarcoma is the most frequently identified neoplasm (1, 2). Other associated pathologic processes involving the mouth include premature periodontal disease, xerostomia, gingival ulcers, venereal warts, and a possible increased incidence of oral squamous carcinoma (1, 3). Recently, oral hairy leukoplakia, primarily involving the tongue, has been seen in up to 28% of homosexual men with serologic evidence of HIV infection or the acquired immunodeficiency syndrome (AIDS) (1, 4, 5).We report a case of extensive...References1. SILVERMANMIGLIORATILOZADA-NURGREENSPANCONANT SCFDM. Oral findings in people with or at risk for AIDS: a study of 375 homosexual males. J Am Dent Assoc. 1986;112:187-92. CrossrefMedlineGoogle Scholar2. LOZADASILVERMANMIGLIORATICONANTVOLBERDING FSCMP. Oral manifestations of tumor and opportunistic infection in the acquired immunodeficiency syndrome (AIDS): findings in 53 homosexual men with Kaposi's sarcoma. Oral Surg Oral Med Oral Pathol. 1983;56:491-4. CrossrefMedlineGoogle Scholar3. LOZADASILVERMANCONANT FSM. New outbreak of oral tumors, malignancies and infectious diseases strikes young male homosexuals. CDA J. 1982;10:39-42. MedlineGoogle Scholar4. GREENSPAN D. Oral viral leukoplakia ("hairy leukoplakia"): a new oral lesion in association with AIDS. In: The Compendium of Continuing Education. Newtown, Pennsylvania: Dental Learning Systems Co.; 1985: 204-8. Google Scholar5. GREENSPANGREENSPANCONANTPETERSENSILVERMANDE SOUZA DJMVSY. Oral "hairy" leucoplakia in male homosexuals: evidence of association with both papillomavirus and a herpes-group virus. Lancet. 1984;2:831-4. CrossrefMedlineGoogle Scholar6. MASURLANEPALESTINE HHA. Effect of 9-(1,3-dihydroxy-2-propoxymethyl) guanine on serious cytomegalovirus disease in eight immunosuppressed homosexual men. Ann Intern Med. 1986;104:41-4. LinkGoogle Scholar7. MARCHENGHUANG EYE. Effect of 9-(1,3-dihydroxy-2-propoxymethyl) guanine on human cytomegalovirus replication in vitro. Antimicrob Agents Chemother. 1983;24:518-21. CrossrefMedlineGoogle Scholar8. CHENGHUANGLIN YEJ. Unique spectrum of activity of 9-(1,3-dihydroxy-2-propoxymethyl)- guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1. Proc. Natl Acad Sci USA. 1983;80:2767-70. CrossrefMedlineGoogle Scholar9. SMEEMARTINVERHEYDENMATTHEWS DJJT. Anti-herpesvirus activity of the acyclic nucleoside 9-(1,3 dihydroxy-2-propoxymethyl) guanine. Antimicrob Agents Chemother. 1983;23:676-82. CrossrefMedlineGoogle Scholar10. FRIEDMAN-KLEIN A. Viral origin of hairy leukoplakia [Letter]. Lancet. 1986;2:694-5. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByViral Infections in Patients with Hematological MalignanciesEpstein-Barr Virus (Infectious Mononucleosis, Epstein-Barr Virus–Associated Malignant Diseases, and Other Diseases)Viral Infections in Patients with Hematological MalignanciesEpstein-Barr Virus (Infectious Mononucleosis, Epstein-Barr Virus–Associated Malignant Diseases, and Other Diseases)A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus–associated lymphoid malignanciesManagement of oral lesions in HIV-positive patientsA random clinical trial study to assess the efficiency of topical applications of podophyllin resin (25%) versus podophyllin resin (25%) together with acyclovir cream (5%) in the treatment of oral hairy leukoplakiaCutaneous manifestations of Epstein-Barr virus infectionEpstein-Barr virus post-transplant lymphoproliferative disease and virus-specific therapy: pharmacological re-activation of viral target genes with arginine butyrateInduction of the Epstein–Barr virus thymidine kinase gene with concomitant nucleoside antivirals as a therapeutic strategy for Epstein–Barr virus–associated malignanciesA retrospective analysis of oral hairy leukoplakia in South AustraliaThe Bystander Effect Mediated by the New Murine Gammaherpesvirus 72 — Thymidine Kinase/5′-Fluoro-2′-Deoxyuridine (MHV72-TK/5-FUdR) System in VitroChanging prevalence of oral manifestations of human immuno-deficiency virus in the era of protease inhibitor therapyORAL INFECTIONS AND OTHER MANIFESTATIONS OF HIV DISEASEThe Epstein-Barr Virus Thymidine Kinase Does Not Phosphorylate Ganciclovir or Acyclovir and Demonstrates a Narrow Substrate Specificity Compared to the Herpes Simplex Virus Type 1 Thymidine KinaseArginine Butyrate-Induced Susceptibility to Ganciclovir in an Epstein–Barr-Virus-Associated LymphomaOral hairy leukoplakia in HIV-positive patientsManagement of Viral Infections in Bone Marrow Transplant RecipientsNew Aspects of Oral Viral DiseasesHIV: The surgeon's perspective Part 2. Diagnosis and management of non-malignant oral manifestationsTreatment of AIDS-Associated Oral Hairy Leukoplakia with CryotherapyAids: Part IIThe Prevalence of Hairy Leukoplakia in HIV Seropositive and HIV Seronegative Immunocompromised PatientsORAL HAIRY LEUKOPLAKIAHIV-Related Infections of the Oral CavitySignificance of oral hairy leukoplakiaManagement of oral health in persons with HIV infectionViruses and chronic disorders involving the human oral mucosaManagement of the Oral Lesions of HIV InfectionOral Manifestations of HIV InfectionOral manifestations of HIV infection and their management. I. More common lesionsOral Hairy LeukoplakiaAcquired Immunodeficiency Syndrome and Epstein-Barr VirusOral hairy leukoplakiaOral manifestations of HIV diseaseORAL HAIRY LEUCOPLAKIAComparison of the efficacy of surgery and acyclovir therapy in oral hairy leukoplakiaOral hairy leukoplakia: observations in 95 cases and review of the literatureOral hairy leukoplakia: Diagnosis and managementHuman Immunodeficiency Virus InfectionHairy leucoplakia.The Natural History and Treatment of EBV Infections and Their Nonmalignant ComplicationsTreatment of cutaneous complications of AIDSResolution of oral hairy leukoplakia during treatment with azidothymidineOral Manifestations of Viral Diseases 1 September 1987Volume 107, Issue 3Page: 348-350KeywordsAIDSHIV infectionsKaposi sarcomaLesionsMouthPeriodontal diseasesPrevention, policy, and public healthTongueUlcersWarts Issue Published: 1 September 1987 PDF DownloadLoading ...