tbuckley/cabot-search huggingface dataset:
TCT-250 A Comparison of Cobalt-Chromium Alloy Stents: Zotarolimus-eluting and Everolimus-eluting in Patients with Diabetes
Authors: Tadashi Miyazaki, Azeem Latib, Vasileios F. Panoulas, Katsumasa Sato, Hiroyoshi Kawamoto, Toru Naganuma, Filippo Figini, Alaide Chieffo, Matteo Montorfano, Mauro Carlino, Antonio Colombo
Journal: Journal of the American College of Cardiology (2014)
Psychologischer Beitrag zum Problem des Spät- und Nachschadens bei Hirnverletzten
Authors: R. Breidt
Journal: Psychotherapy and Psychosomatics (1974)

An early aging-process by brain damages and a deterioration of the various consequences of non-perforated brain injuries is generally rejected on the basis of research in the anatomic-pathological field and due to neurological experiences. A psychological pilot study is referred, showing the possibility of a partial early psychic aging in the sense of a higher perseveration or rigidity, more confined thinking and more reduced flexibility of brain injured people. The hypothesis of a partial progression of mental reduction due to brain injury and age is discussed. The conclusion is further research and discussion of the problem between deterioration and second damage, mainly with psychological methods in the mental field.
Lectures ON THE STRUCTURE, FUNCTIONS, AND DISEASES OF THE SKIN: DELIVERED AT THE BELFAST GENERAL HOSPITAL DURING THE SESSIONS, 1851-2 TO 1855-6 INCLUSIVE
Authors: A. G. Malcolm
Journal: BMJ (1856)

qumt repetition, it ains so firm a hold upon public credie, that to doubt is to be guilty of heretical scepticism.So indiosed, or so incapable, to investigate any sciesi- tile matter ae too many, that they will readily save themselves that trouble by indulging their credulity.
Autolysed Yeast for Nutritional Macrocytic Anaemia
Authors: G. R. Sippe
Journal: BMJ (1944)

JOURN.41 Case 17.-Female, 38 years.Abscess and sinuses of abdominal wall for 12 months.600 units during 7 weeks, with sulphapyridine powder during part of time, almost ended profuse suppuration, closed sinuses and gape of wound, and improved general condition.(Mr. I. Price.)Case 18.-Female, adult.Large breast abscess with much swelling of surrounding breast; incised and one pint of pus removed.200 units of penicillium filtrate instilled twice a day during five days reduced discharge to a little sero-pus and brought surrounding tissues to normal.-(Dr.G. M. Palser.)Case 19.-Female, 65 years.Cellulitis and suppuration in resutured abdominal operation wound.Local treatment by sulphacetamide (albucid) and by eusol produced very slow progress during two months; 150 units during 5 days ended suppuration, reduced sinuses and gape of wound, and produced healing edge all round. (Mr. W. T. Kenny.)Case 20.-Female, 17 years.Two abscesses in right breast.The larger, after incision, treated with 300 units during 3 weeks, healed well in spite of a near-by pocket requiring another incision.This illustrated need for close contact of penicillin with the suppurating lesion, and the result was considered only moderately successful. (Dr.G. M. Palser.)Caise 21.-Male, adult.Osteomyelitis of tibia greatly improved in healthy granulation by 170 units; unopened abscess produced septicaemia, successfully treated by sulphathiazole.Rapid healing of sinuses and abscess then resumed.Septicaemia recurred.Systemic administration of penicillin needed.(Mr. E. T. Bailey.)Case 22.-Female, 40 years.Acute breast abscess.After incision, 200 units in 9 days, followed by healing not more rapid than normal. (Dr.G. M. Palser.)Case 23.-Female, 10 months.Subacute suppurative cellulitis of temporal region and brain abscess (probably due to B. nzecrophorus).Profuse suppuration in muscles of temporal and pterygoid regions subsided to oedema after 80 units during one week, but pus had rapidly decreased previously without penicillin.Necrosis of mastoid cells found at operation, and child died same day.At necropsy a well-encapsulated abscess in temporal lobe of brain without apparent connexion with surface; no suppuration in tissues outside skull.Effect of filtrate doubtful.(Mr. McCrea.)Case 24.-Male, elderly.Chronic osteomyelitis and sinus of thigh.Very little improvement with 280 units of filtrate in a week followed by 250 units of calcium salt, although Staph.autreus isolated was quite sensitive to penicillin.(
Doctors' perceptions of pressure from patients for referral.
Authors: D Armstrong, J Fry, P Armstrong
Journal: BMJ (1991)

OBJECTIVE--To assess the effect of pressure from patients on patterns of general practitioners9 outpatient referrals. DESIGN--Survey of general practitioners9 referrals to hospital outpatient departments during one week. SETTING--One health district. SUBJECTS--All (160) general practitioners in the health district. MAIN OUTCOME MEASURES--Specialty of the referral, the reason for it, and its status (NHS or private) and the general practitioner9s assessment of the degree of pressure exerted by the patient for the referral (much, little, or none). RESULTS--122 (76%) general practitioners completed the survey. Younger general practitioners (aged less than or equal to 45) and those qualifying in the United Kingdom and Republic of Ireland reported greater pressure from patients to refer (p less than 0.03, p less than 0.001 respectively). Pressure was also greater for patients referred privately (p less than 0.001), for those referred for reassurance (p less than 0.05), and for those referred to clinics in psychiatry, rheumatology, dermatology, and orthopaedics. General practitioners with a higher referral rate (with total consultations in the week as the denominator) were more likely to report pressure (p less than 0.01). CONCLUSIONS--The pressure from patients to refer reported by general practitioners is related both to general practitioners9 characteristics and to the nature of the referral. Pressure to refer seems to explain some of the variation in referral rates among general practitioners.
From Clinical Observation to Mechanism — Heyde's Syndrome
Authors: Joseph Loscalzo
Journal: New England Journal of Medicine (2012)

In 1958, E.C. Heyde noted an association between aortic-valve stenosis and GI bleeding, which led to identification of the mechanism of the bleeding: fragmentation of high-molecular-weight multimers of von Willebrand factor on the stenotic valve led to acquired von Willebrand's disease.
Remarks on Tropical Diarrh a as Seen in this Country
Authors: J. Fayrer
Journal: BMJ (1889)

be pushed forwards, and in places visibly in contact with the periphery of the cornea.By placing the vitreous reservoir 15 centumntres higher than the aqueous reservoir it was possible to empty the anterior chamber almost completely, and to apply the =hole iris close to the cornea; and under these circumstances the escape by filtration from the whole eye appeared in some in- stances to be entirely arrested.Similar experiments upon the freshly-excised eyes of oxen, and in one instance on a freshly-excised healthy human eye removed with an orbital tumour, gave closely similar results.With regard to the escape at the papilla I made some further experiments with the smaller apparatus, Mhown half-size, in section, in Fig. 6.A circular piece, including choroid, sclera, retina, and optic, nerve, is cut from the back of a sheep's eye immediately after death and placed in the box, and the inner tube is tightly pressed down upon it by screwing on the cap of the box.The iner tube is then filled with coloured fluid and connected by a flexible tube with a graduated glass tube and reservoir, as in the other apparatus.Under a pressure of 30 centimetres, as before, there was no perceptible exudation and no coloration on the outer surface after several hours.These experiments show several points of importance with re- gard to the freshly-excised eye.They show, firstly, that fluid mjected into the vitreous chamber escapes chiefly, if not entirely, through the aqueous chamber; secondly, that a slight excess of presure in the vitreous chamber displaces the lens and iris forwards, compresses the filtration angle, and impedes the escape of fluid; thirdly, that 1here i3 little, if any, escape at the papilla.With regard to the currents in the living eye, they give, of course, no positive information.(Since this lecture was delivered I have read with much in- terest that Dr. Leplat, adopting a method nearly the same as that above detailed, has made a further series of experiments upon living animals.His results confirm to a large extent those ob- tained by myself with the freshly-excised eye.He concludes that the escape at the papilla is about one-fiftieth of the escape at the filtration angle.22)
Barium Impaction in the Sigmoid Colon
Authors: W M McDonnell, F Jung
Journal: New England Journal of Medicine (1997)

Figure 1. A 54-year-old woman with lung cancer presented with severe abdominal pain and bilious vomiting. She had had a diagnostic barium small-bowel follow-through 10 days earlier for nausea and vomiting. She had undergone a partial left lobectomy in 1987 and 1992 and a Billroth II gastric resection many years earlier for peptic ulcer disease. On examination she was dehydrated and had diffuse abdominal tenderness but no peritoneal signs. Abdominal plain films showed inspissated barium (arrows in Panels A and B) in the sigmoid colon. Efforts to break up the impaction manually failed. Flexible sigmoidoscopy was attempted, but a solid . . .
Thermodynamic Characterization of the Contractile State of the Myocardium
Authors: MARTIN E. BLOOMFIELD, LOUIS D. GOLD, REDDY V. REDDY, ADOLPH I. KATZ, AUGUSTO H. MORENO
Journal: Circulation Research (1972)

Definition of the contractile state of the myocardium from force, length, and velocity relationships and measurements of ventricular pressure is a continuum mechanics approach that requires a detailed knowledge of the system under consideration or, in the absence of detailed knowledge, the use of suitable conceptual models. In this paper we proposed a simpler, though still rigorous, approach that required only a general, rather than a detailed, a priori knowledge of the system. Using the theory of thermodynamics, we gained some insight into the physical meaning of the time derivatives of the left ventricular pressure pulse. From integrations and normalizations we obtained power-density functions (energy-averaged power density and power-averaged rate of generation of power density). These functions relating the free energy in the myocardium to the pressure in the blood did not require geometric considerations, and they furnished, to a first approximation, a quantification of the contractile state in a population of 26 normal dogs under anesthesia. Moreover, the functions clearly separated the normal state from abnormal ones created by drug intervention, not only in the same dog, but also in different dogs. The functions appeared to be insensitive to volume loading. In two patients studied before and after surgery, these functions also showed significant changes.
Sulfasalazine Revisited
Authors: Lloyd R. Sutherland
Journal: Annals of Internal Medicine (1993)

Purpose: To assess the effectiveness of the newer 5-aminosalicylic acid (5-ASA) delivery systems compared with placebo or sulfasalazine for the treatment of active ulcerative colitis and for the maintenance of remission. Data Sources: Pertinent studies were selected using the MEDLINE and BIOS (1981 to 1992) data bases, reference lists from published articles, reviews, symposia proceedings, and abstracts from major gastrointestinal meetings. Study Selection: Randomized controlled trials of 5-ASA compared with placebo or sulfasalazine of a minimum of 4 weeks duration for active disease and a minimum of 6 months for maintenance of disease remission. Sixteen trials of 5-ASA for active disease, published either in abstract or full manuscript, were available. Eleven trials of 5-ASA for maintenance of remission were also reviewed. Data Extraction: Crude rates for either induction of remission (active disease studies) or maintenance of remission (relapse-prevention trials) based on the intention-to-treat principle were extracted from the studies by two independent observers. Each study was given a quality score, based on predetermined criteria. Results: Studies were placed in three groups: 5-ASA compared with placebo, 5-ASA compared with sulfasalazine for active disease, and 5-ASA compared with sulfasalazine for maintenance of remission. 5-Aminosalicylic acid was superior to placebo in the treatment of active ulcerative colitis (pooled odds ratio, 2.02; 95% CI, 1.50 to 2.72). A dose-response effect for 5-ASA existed (P < 0.001). For active disease, the pooled odds ratio for 5-ASA compared with sulfasalazine was 1.15 (CI, 0.83 to 1.61). When 5-ASA was compared with sulfasalazine for maintenance of disease remission, the pooled odds ratio was 0.85 (CI, 0.64 to 1.15). Withdrawal rates and reported side effects were similar for 5-ASA compared with placebo- or sulfasalazine-treated patients. Conclusions: Although the newer 5-ASA preparations in a dose of at least 2 g/d are more effective than placebo in the treatment of ulcerative colitis, insufficient evidence exists to suggest that they are superior to sulfasalazine. Although they offer a benefit to the sulfasalazine-sensitive patient, use of 5-ASA preparations instead of sulfasalazine in the treatment of ulcerative colitis cannot yet be substantiated.
Abstract 3415: Therapeutic targeting of the ASPL-TFE3 gene fusion in ASPS-1, a novel cell line derived from metastatic alveolar soft part sarcoma (ASPS)
Authors: David T. Vistica, Susan Kenney, Sandra Burkett, Melinda Hollingshead, Suzanne Borgel, Donna Butcher, David S. Schrump, Robert H. Shoemaker
Journal: Cancer Research (2010)

Abstract Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma primarily affecting young children and adolescents. ASPS is characterized by a nonreciprocal chromosomal translocation, der(17)t(X;17)(p11;q25), in which the N-terminal region of the alveolar soft part locus (ASPL) gene, located at 17q25, is fused to the C-terminal region of the transcription factor E3 (TFE3), located at Xp11. Two alternative fusion junctions have been observed resulting in the expression of 2 distinct fusion transcripts, ASPL-TFE3 type 1 and 2, and their respective proteins which function as hybrid transcription factors. Recently we have described the first xenograft model of ASPS, established from a lymph node metastasis derived from a female patient expressing the ASPL-TFE3 type 1 fusion, in NOD.SCID mice (J. Pediatr. Hematol. Oncol 31:561, 2009) and an ASPS cell line, ASPS-1, derived from it (Proc. Amer. Assoc, Cancer Res. 50:978, 2009). We report here our efforts to target the ASPL-TFE3 type 1 gene fusion (CGG GAG CGG CTG CCT GTG TCA) in ASPS-1 cells using siRNA directed against its nucleotide sequence and compared results with siRNA directed against the ASPL-TFE3 type 2 gene fusion (CGG ATT GAT GAT GTC ATT GAT). ASPL-TFE3 type 1 and 2 siRNA were evaluated in vitro in ASPS-1 cells, which express the ASPL-TFE3 type 1 gene fusion and protein, at concentrations ranging from 1-50 nM and treatment times ranging from 3-12 days. These results indicate that the ASPL-TFE3 type 1 siRNA, but not the ASPL-TFE3 type 2 siRNA or a control siRNA not known to target any human gene, was effective in reducing the ASPL-TFE3 type 1 fusion transcript, the ASPL-TFE3 type 1 fusion protein and retarding the growth of ASPS-1 cells. Importantly the ASPL-TFE3 type 1 siRNA down regulated several signature ASPS genes (BMC Cancer 9:22, 2009) including those involved in angiogenesis of this highly vascular tumor (ANGPTL2, MDK, c-MET, and TIMP-2). Additionally, PCSKI, a proprotein convertase responsible for processing of neuropeptides, growth factors and receptors, and several tissue restricted markers including ITGB1BP3, was strikingly down regulated. Together these results suggest that the ASPL-TFE3 fusion gene and its fusion protein play an important role in pathways involved in the growth of ASPS and present potentially exploitable targets for development of novel therapeutics. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3415.
Diagnostic evaluation of t(4;14) in multiple myeloma and evidence for clonal evolution
Authors: A K Stewart, H Chang, S Trudel, K C Anderson, P Richardson, M Alsina, D Reece, S Young, A Sable-Hunt, Z Li, J Keats, S Van Wier, G Ahmann, T Price-Troska, K Giusti, P L Bergsagel, M Chesi, R Fonseca
Journal: Leukemia (2007)
Erythropoietic protoporphyria: Altered phenotype after bone marrow transplantation for myelogenous leukemia in a patient heteroallelic for ferrochelatase gene mutations
Authors: Maureen B. Poh-Fitzpatrick, Xiuhua Wang, Karl E. Anderson, Joseph R. Bloomer, Brian Bolwell, Alan Eli Lichtin
Journal: Journal of the American Academy of Dermatology (2002)
TUBERCULOSIS OF THE KIDNEY IN CHILDHOOD
Authors: O. L. Addison
Journal: BMJ (1935)

CHILDREN(With Special Plate) luberculous diisease ot tne kldney, apart irom miliary tuberculous, is among the rarer manifestations of the disease in childhood, and comparatively few cases are seen under the age of 10 or 11.No age, however, is exempt, and advanced examples may sometimes be found even in infancy (Figt 1 on Plate).
Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction
Authors: Siyoung Yang, Jonghwan Kim, Je-Hwang Ryu, Hwanhee Oh, Churl-Hong Chun, Byoung Ju Kim, Byoung Hyun Min, Jang-Soo Chun
Journal: Nature Medicine (2010)
Necrobiosis lipoidica: only a minority of patients have diabetes mellitus
Authors: None O'TOOLE, None KENNEDY, None NOLAN, None YOUNG, None ROGERS, None BARNES
Journal: British Journal of Dermatology (1999)

Although it is commonly accepted that necrobiosis lipoidica (NL) is associated with diabetes mellitus (DM), there is some controversy regarding the degree of this association. In a retrospective review of 65 patients with NL attending our dermatology out-patient clinics we found that just seven (11%) were known to have DM at the time of presentation. Seven further patients (11%) were diagnosed as having impaired glucose tolerance/DM at presentation and over a 15-year follow-up period. Thus, only a minority of our patients with NL had DM.
Acute Renal Failure During Treatment With Ticrynafen
Authors: Hiroki Sawa
Journal: JAMA (1980)

TICRYNAFEN is a new antihypertensive, uricosuric diuretic.<sup>1,2</sup>Substantial uricosuria may complicate the initial response to the drug. Because renal tubular blockade by the precipitation of uric acid is possible, discontinuation of current diuretic therapy for three days and liberalization of fluid intake before the initiation of ticrynafen therapy has been suggested (Philip J. Tannenbaum, MD, Smith Kline &amp; French Laboratories, written communication, Sept 17, 1979). We describe here a case of acute renal failure during treatment with ticrynafen used as the sole antihypertensive agent. <h3>Report of a Case</h3> A 52-year-old physician, a known hypertensive for the last six years, was controlled with chlorthalidone, 100 mg daily. In May 1979, his blood pressure was 132/82 mm Hg. The BUN level was 14 mg/dL, with serum creatinine level of 0.9 mg/dL. Results of urinalysis were normal. Complete blood cell count was normal, with a hematocrit value of 41.4%. Because of an
Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 Is Involved in gp130 Resistance in Cardiovascular System in Rat Treated With Cardiotrophin-1 In Vivo
Authors: Ichiro Hamanaka, Yoshihiko Saito, Hideo Yasukawa, Ichiro Kishimoto, Koichiro Kuwahara, Yoshihiro Miyamoto, Masaki Harada, Emiko Ogawa, Noboru Kajiyama, Nobuki Takahashi, Takehiko Izumi, Rika Kawakami, Izuru Masuda, Akihiko Yoshimura, Kazuwa Nakao
Journal: Circulation Research (2001)

Abstract —CIS (cytokine-inducible SH2 protein), SOCS (suppressor of cytokine signaling), or SSI (signal transducers and activators of transcription [STAT]-induced STAT inhibitor) proteins are a family of cytokine-inducible negative regulators of cytokine signaling via Janus kinase (JAK)-STAT pathways. Given the evidence that the JAK-STAT pathway plays a critical role in the cardiovascular system, the primary objective of this study was to assess the effects of the CIS family on JAK-STAT signaling in the cardiovascular system in rats treated with cardiotrophin-1 (CT-1), an interleukin-6 family of cytokines. Intravenous injection of 20 μg/kg body weight of CT-1 induced a transient, marked increase in STAT3 activation in various tissues, including heart and lung, and subsequent upregulation of 2 members of the CIS family, JAK-binding protein (JAB)/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3, in the same tissues. It was also observed that CIS3 was directly associated with JAK2 in vivo. Pretreatment with the same dose of CT-1 60 minutes before significantly attenuated the STAT3 activation induced by a second injection of CT-1. We previously reported that intravenous injection of CT-1 results in the nitric oxide (NO)-dependent hypotension accompanied by the induction of inducible NO synthase mRNA. In rats pretreated with CT-1, the induction of inducible NO synthase mRNA or hypotension by subsequent CT-1 injection was not observed. Forced expression of JAB or CIS3, but not other CISs, directly blocked CT-1–induced STAT3 activation in 293 cells. These results suggest that JAB and CIS3 serve as endogenous inhibitors of CT-1–mediated JAK-STAT signaling in the cardiovascular system in vivo.
Colonic Dendritic Cells, Intestinal Inflammation, and T Cell-Mediated Bone Destruction Are Modulated by Recombinant Osteoprotegerin
Authors: A.J Ashcroft, S.M Cruickshank, P.I Croucher, M.J Perry, S Rollinson, J.M Lippitt, J.A Child, C Dunstan, P.J Felsburg, G.J Morgan, S.R Carding
Journal: Immunity (2003)
Brain Control: A Critical Examination of Brain Stimulation and Psychosurgery
Authors: John F. Mullan
Journal: JAMA (1975)

The book is best when dealing with laboratory studies, since the author was a behavioral physiologist. The inquisitive reader will find here an introduction to the whole field of electrical stimulation in animals and in man. Dr. Valenstein's comments will help him realize that this field has been harvested by individuals of widely ranging experience, precision, self-criticism, and enthusiasm. The clinical sections are decidedly weaker. Few neurosurgeons will understand the inclusion of the surgical treatment of involuntary movement, epilepsy, and pain under the heading of psychosurgery, which is the surgical treatment of psychiatric illness. Few will agree with the cursory review given these subjects in which the dangers and uncertainties are emphasized without recognition of the happiness experienced by those patients who have thrown off their dyskinesia, their epilepsy, or their intractable pain. The sections on psychosurgery itself receive a more adequate treatment, but the uninformed reader might emerge from
Persistence of allergic contact sensitivity in subjects with photosensitivity dermatitis and actinic reticuloid syndrome
Authors: H.A. ADDO, W. FRAIN-BELL
Journal: British Journal of Dermatology (1987)

We report the maintenance of allergic contact sensitivity in 20 subjects with photosensitivity dermatitis and actinic reticuloid syndrome. Positive patch test reactions were demonstrated some years after the initial diagnosis and after significant maintained improvement of the photodermatosis had occurred.