tbuckley/cabot-search huggingface dataset:
Physicians' Attitudes about Patients in the Persistent Vegetative State
Authors: Kirk Payne
Journal: Annals of Internal Medicine (1997)

Letters1 January 1997Physicians' Attitudes about Patients in the Persistent Vegetative StateKirk Payne, MD, Robert M. Taylor, MD, and Carol Stocking, PhDKirk Payne, MDUniversity of Virginia Health Sciences Center; Charlottesville, VA 22908Ohio State University Medical Center; Columbus, OH 43210-1228University of Chicago Medical Center; Chicago, IL 60637-1470Search for more papers by this author, Robert M. Taylor, MDUniversity of Virginia Health Sciences Center; Charlottesville, VA 22908Ohio State University Medical Center; Columbus, OH 43210-1228University of Chicago Medical Center; Chicago, IL 60637-1470Search for more papers by this author, and Carol Stocking, PhDUniversity of Virginia Health Sciences Center; Charlottesville, VA 22908Ohio State University Medical Center; Columbus, OH 43210-1228University of Chicago Medical Center; Chicago, IL 60637-1470Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-1-199701010-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Gillick's concern that survey respondents may have included severely demented patients in the category of the PVS is valid, especially given the fact that almost one third of respondents believe these patients experience pain and suffering and 13% believe they experience hunger and thirst. These similarities between the beliefs of neurologists and medical directors about patients in the PVS suggest that both groups were referring to the same category of patients. Our survey determined neither whether physicians are unfamiliar with the diagnostic criteria for the PVS nor whether they are familiar with the criteria but do not ...References1. A controlled trial to improve care for seriously ill hospitalized patients. The study to understand prognoses and preferences for outcomes and risks of treatments (SUPPORT) Principal Investigators. JAMA. 1995; 274:1591-8. Google Scholar2. Cassell EJ. Clinical incoherence about persons: the problem of the persistent vegetative state [Editorial]. Ann Intern Med. 1996; 125:146-7. Google Scholar Author, Article, and Disclosure InformationAuthors: Kirk Payne, MD; Robert M. Taylor, MD; Carol Stocking, PhDAffiliations: University of Virginia Health Sciences Center; Charlottesville, VA 22908Ohio State University Medical Center; Columbus, OH 43210-1228University of Chicago Medical Center; Chicago, IL 60637-1470 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1997Volume 126, Issue 1Page: 90KeywordsBehaviorCardiopulmonary resuscitationHealth care policyLiving willsMedical dialysisMotivationPatientsPersistent vegetative stateVentilators ePublished: 15 August 2000 Issue Published: 1 January 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
RIVAROXABAN IN THE SETTING OF CONTINUED DUAL ANTIPLATELET THERAPY: FINDINGS FROM THE ATLAS ACS 2-TIMI 51 TRIAL
Authors: Jessica L. Mega, Eugene Braunwald, Sabina Murphy, Alexei Plotnikov, Nancy Cook-Bruns, Philip Aylward, Vijay Chopra, Runlin Gao, Jose Nicolau, C. Michael Gibson
Journal: Journal of the American College of Cardiology (2013)
Clinical Lecture on Surgical Diagnosis
Authors: C. Heath
Journal: BMJ (1875)

GENTLEMIEN,-As the Special Professor of Clinical Surgery, it is my special duty to instruct you to the best of my ability in the diagnosis and treatment of surgical disease and injury.Much of my teaching must necessarily be at the bedside; but the clinical lecture which I shall deliver each Monday in this theatre will give me the opportunity of commenting more freely upon the cases you will find in the wards, than would be convenient before the patients themselves.The weekly clinical examination of actual patients by yourselves, or, at least, by the seniors of the class in your presence, will also, I hope, help to train you in the diagnosis of surgical cases; and I propose to devote this lecture to giving you some practical hints on the subject.Many surgical injuries and affections are so obvious that no great skill is required for their recognition; but, on the other hand, similar outward appearances may depend upon very different causes ; and it is here that the skill in diagnosis of the surgeon gives him the advantage in prescribing appropriate treatment.Symptoms may be conveniently divided into "objective" and "subjective'; the former being those open to the observation of the surgeon, the latter those experienced only by the patient.It is to the objective symptoms of disease and injury that I propose to direct your attention to-day; for I do not mean, on this occasion, to bring a patient before you, but simply a living model with no special ailment, to illustrate some points in dia- gnosis.
Evaluation of Endoscopic and Histopathological Features of Serrated Adenoma of the Colon
Authors: T. Morita, S. Tamura, J. Miyazaki, Y. Higashidani, S. Onishi
Journal: Endoscopy (2001)

The aim of this study was to reveal the clinical features of serrated colonic adenoma by investigating its endoscopic features using a magnifying videoscope.68 colorectal serrated adenomas presented for colonoscopic examination were included in this study. A magnifying videoscope with a zoom ranging from x 1 to x 100 magnification was employed to observe the pit patterns of colonic lesions, and 39 of the serrated adenoma specimens were evaluated using this. Some pit patterns appeared as elongated oval and stellar-like orifices of the crypts; we termed these type which was detected III(SA) patterns. Other pit patterns showed a flower petal-like or pineal form, and this was termed a type IV(SA) pit pattern.In the entire sample of serrated adenomas, 53 were of the protruded type, and 15 were superficial, for a protruded/superficial ratio of 3.5 : 1. The protruded type of serrated adenoma predominated in the distal portion. The superficial type was preferentially located in the proximal portion of the colon (P < 0.0001). Among the 13 superficial types in which the magnifying videoscope was used, all 13 showed the type III(SA) basic pit pattern. In these serrated adenomas of the superficial type, an additional IV(SA) pit pattern was found in 23.1% (3/13), which was detected in 53.8% (14/26) in the protruded type. Small serrated adenomas measuring less than 10 mm in diameter were preferentially mild to moderate atypia (odd's ratio = 15.9, P = 0.0216).The pit pattern may prove useful for the endoscopic diagnosis of serrated adenoma. Furthermore, endoscopic treatment is indicated for serrated adenoma; in particular those of 10 mm or more in diameter should be treated because of the possibility of high-grade glandular intraepithelial neoplasia.
Safety of stainless steel in nickel sensitivity
Authors: A. A. Fisher
Journal: JAMA (1972)

<h3>To the Editor.—</h3> A recent letter by Barranco and Solomon "Eczematous Dermatitis from Nickel," (220:1244, 1972) described a dermatitis in a nickel-sensitive patient from a stainless steel screw used to secure a transferred tendon for a dislocated patella as an example of "internal" allergic contact dermatitis. The authors state that a 4+ reaction was obtained with the stainless steel screw. However, not infrequently, hard metallic objects under a covered patch produce pressure, irritant reactions which are difficult to distinguish from the allergic variety. This is particularly so in individuals who have, or have recently recovered from an eczematous reaction which makes the skin irritable in a nonspecific manner. Furthermore, even though the stainless steel screw contained 14% nickel, this nickel is so firmly bound physically in the alloy, that body fluids or perspiration cannot "leach" out the nickel to make it available to produce an allergic reaction. The presence or
Abstract 1049: PIM2 inhibitor as a targeted therapy for the treatment of multiple myeloma patients with specific genetic signatures.
Authors: Carmen M. Baldino, Justin Caserta, Stephane Dumas, Yvonne Flanders, Jayakumar Nair, Kelvin P. Lee
Journal: Cancer Research (2013)

Abstract Jasco Pharmaceuticals has developed a novel and selective pan-PIM inhibitor (JP_11646) that has demonstrated biochemical IC50s of 24, 0.5 and 1 nM for PIM1, PIM2 and PIM3 respectively. Jasco also developed an engineered cell line to measure PIM2 transphosphorylation by over-expressing human PIM2 in human HEK293 cells together with human BAD as the substrate. The cell based assay measures the phosphorylation levels of BAD at Ser112 attributed solely to PIM2. JP_11646 exhibited a 590 nM IC50 in this cell based PIM2 assay confirming the MOA. JP_11646 increases apoptosis and decreases cell viability in multiple myeloma cell lines with the t(14;16) and t(4;14) translocations, which are known markers for poor prognosis. JP_11646 is orally bioavailable and has demonstrated in vivo efficacy, inhibiting tumor growth by &amp;gt;80% in a MM1.S tumor xenograft study. These data provide solid rationale for further development of JP_11646 as a targeted therapy for specific population of multiple myeloma patients that exhibit these genetic markers. Citation Format: Carmen M. Baldino, Justin Caserta, Stephane Dumas, Yvonne Flanders, Jayakumar Nair, Kelvin P. Lee. PIM2 inhibitor as a targeted therapy for the treatment of multiple myeloma patients with specific genetic signatures. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1049. doi:10.1158/1538-7445.AM2013-1049
127Xe Ventilation Imaging Immediately Following99mTc Perfusion Studies
Authors: H M CHILTON, J F COOPER, B I FRIEDMAN
Journal: Clinical Nuclear Medicine (1977)

Presently, 133Xe is the radiogas most widely used for pulmonary ventilation imaging. It has been suggested that the newly available radiogas 127Xe is superior to 133Xe because of its higher photon yield, more suitable photon energies, lower radiation dose and longer shelf-life. Because 127Xe photon energy values are significantly greater than those of 99mTc, we have investigated the additional advantage that 127Xe may be utilized for ventilation imaging immediately following 99mTc-labeled perfusion studies.
P177 Patient-related Outcome Measurements In Pleural Effusions
Authors: I. Psallidas, J. Corcoran, E. Mishra, R. Hallifax, N. Rahman
Journal: Thorax (2014)

<h3>Introduction</h3> Pleural disease is a common health problem in the general population and the number of pleural interventions available to physicians is rapidly expanding. Most clinical studies to date have focused on the generation of successful treatments for pleural diseases without considering patient-centred assessments of symptomatic relief in a procedure undertaken for patient benefit. Patient-related outcome measures (PROMs) such as the assessment of pain and difference in dyspnoea have been used in other disease areas to estimate effectiveness and guide interventions. This prospective study measured PROMs after pleural interventions using a specific survey questionnaire. <h3>Methods</h3> Data were collected from 95 patients treated in a tertiary referral centre from December 2013 to June 2014. Pleural interventions included diagnostic aspiration, therapeutic aspiration, thoracoscopy, intercostal chest drain insertion and indwelling pleural catheter insertion. We gathered information on pain, dyspnoea, expected improvement and willingness to repeat the procedure if needed using a 100 mm visual analogue scale (VAS). Clinical, radiological and histological data were recorded and categorised the patients with pleural effusions to either: malignant, infected, heart failure and undiagnosed. Patients with pneumothorax were classified to either primary or secondary. Data are presented as mean ± SD. <h3>Results</h3> Data were collected from 31 therapeutic aspirations, 30 intercostal drain insertions, 17 diagnostic/simple aspirations, 14 thoracoscopies and 3 indwelling catheter insertions. The results showed the procedure associated with the most pain is medical thoracoscopy (VAS: 20 ± 20.3 mms) whereas diagnostic aspiration (VAS: 2.52 ± 4.78 mms) was the least uncomfortable. Pain measurements were similar in intercostal and indwelling pleural catheter insertion groups (p: 0.75). VAS score for dyspnoea demonstrated that intercostal drain insertion had the greatest effect on patients’ breathlessness compared to the other procedures (VAS difference pre and post-procedure: 50.8 ± 27 mms).99.8% of the patients would repeat any of the pleural procedures if needed. <h3>Conclusion</h3> Our study, the first to prospectively assess patient-related outcomes in pleural procedures, demonstrates that different pleural procedures significantly improve symptoms alongside a high degree of patient satisfaction. Pleural PROMs may represent a standardised way of measuring symptomatic benefit which can be used in both clinical practice and future research.
A Clinical and Immunological Study of Allergy to Hen's Egg White
Authors: Tor Langeland, Ole Harbitz
Journal: Allergy (1983)

Antigen 22 (ag-22) in hen's egg white, previously shown to be one of the major allergens in the egg white, was partially purified by combining biochemical separation techniques and quantitative immunoelectrophoretic methods. The molecular weight of ag-22 was found to be approximately 78,000 using analytical ultracentrifugation and pI was determined to be 6.1, which is appropriate with the values of ovotransferrin. It was concluded that ag-22 is identical with ovotransferrin. The ability of ovotransferrin to react in the human IgE-system was demonstrated in vivo and in vitro, by means of skin prick tests and crossed radioimmunoelectrophoresis.
Conjugation of organic pollutants in aquatic species.
Authors: M O James
Journal: Environmental Health Perspectives (1987)

Aquatic organisms can take up organic pollutants from their environment and subsequently excrete the pollutant or its biotransformation products (metabolites). Phase II (conjugation) biotransformation products are almost always less toxic than the unmetabolized organic pollutant. For many organic pollutants, the extent to which conjugates are formed is extremely important in determining the rate of excretion of the pollutant. This is because most conjugates (glycosides, sulfates, amino acid conjugates, mercapturic acids) are organic anions which are readily water-soluble and are rapidly excreted by fish (and probably higher invertebrates) by a combination of glomerular filtration and tubular transport. In this paper, each major conjugation pathway is discussed with respect to what is known about its occurrence in fish and aquatic invertebrates, both from in vivo and in vitro data. Although limited data are available, this paper also considers what is known about how each conjugation reaction affects the toxicity and potential for renal and biliary excretion of organic xenobiotic substrates.
Points: Doctors and the death penalty: an international issue
Authors: P. Doherty
Journal: BMJ (1987)

Dr Norman D Noah (16 May, p 1270) rightly draws attention to the comparatively limited information available on compulsory childhood immunisation and its impact in eastern European countries.He specifically mentions Czechoslovakia, a country which I recently visited as a medical geographer with a specific interest in vaccination uptake and the epidemiology of infectious disease.In Czechoslovakia virtual eradication ofmeasles seems to have been attained by a combination of compulsory childhood immunisation and the measures which Dr Noah commends: administrative methods, health education, and service delivery.Though immunisa-
GUINEA-PIG INOCULATION FOR TUBERCLE TEST
Authors: Raymond L. Schulz
Journal: JAMA (1923)

Several methods of facilitating the rapid recovery of tubercle bacilli from inoculated guinea-pigs have been suggested. Intraperitoneal inoculation requires at least six weeks for the satisfactory development of lesions, subcutaneous inoculation at least four weeks. Exposure to roentgen rays previous to inoculation has been suggested to increase the susceptibility and make possible a recovery of the tubercle bacillus in two weeks. With intrahepatic inoculation, a search for tuberculous abscess is made after two weeks. All these methods require killing the animal, the test is interrupted, and further observation is impossible, particularly in apparently negative or doubtful cases. Besides, it may be necessary in some of these tests to make tissue examinations in order to arrive at a diagnosis. With intracutaneous inoculation, a result can be obtained in less than two weeks; the development and location of the lesion are always under observation, and the animal may be kept alive for
Low back pain of mechanical origin: randomised comparison of chiropractic and hospital outpatient treatment.
Authors: T W Meade, S Dyer, W Browne, J Townsend, A O Frank
Journal: BMJ (1990)

To compare chiropractic and hospital outpatient treatment for managing low back pain of mechanical origin.Randomised controlled trial. Allocation to chiropractic or hospital management by minimisation to establish groups for analysis of results according to initial referral clinic, length of current episode, history, and severity of back pain. Patients were followed up for up two years.Chiropractic and hospital outpatient clinics in 11 centres.741 Patients aged 18-65 who had no contraindications to manipulation and who had not been treated within the past month.Treatment at the discretion of the chiropractors, who used chiropractic manipulation in most patients, or of the hospital staff, who most commonly used Maitland mobilisation or manipulation, or both.Changes in the score on the Oswestry pain disability questionnaire and in the results of tests of straight leg raising and lumbar flexion.Chiropractic treatment was more effective than hospital outpatient management, mainly for patients with chronic or severe back pain. A benefit of about 7% points on the Oswestry scale was seen at two years. The benefit of chiropractic treatment became more evident throughout the follow up period. Secondary outcome measures also showed that chiropractic was more beneficial.For patients with low back pain in whom manipulation is not contraindicated chiropractic almost certainly confers worthwhile, long term benefit in comparison with hospital outpatient management. The benefit is seen mainly in those with chronic or severe pain. Introducing chiropractic into NHS practice should be considered.
Glucocorticoids protect renal mesangial cells from apoptosis by increasing cellular sphingosine-1-phosphate
Authors: Ankathrin Förster, Tanja Emmler, Stephanie Schwalm, Mahsa Ebadi, Dagmar Meyer zu Heringdorf, Barbara Nieuwenhuis, Burkhardt Kleuser, Andrea Huwiler, Josef Pfeilschifter
Journal: Kidney International (2010)
Directional atherectomy for treatment of restenosis within coronary stents: Clinical, angiographic and histologic results
Authors: Bradley H. Strauss, Victor A. Umans, Robert-Jan van Suylen, Pim J. de Feyter, Jean Marco, Gregory C. Robertson, Jean Renkin, Guy Heyndrickx, Vojislav D. Vuzevski, Fred T. Bosman, Patrick W. Serruys
Journal: Journal of the American College of Cardiology (1992)
Partnership between NHS and pharmaceutical sector is needed
Authors: T. Yamada
Journal: BMJ (2001)

EDITOR—Smith's news item reported my concerns on the declining status of the NHS as a location for clinical trials conducted by pharmaceutical companies, and was clear and accurate.1 Smith drew on material compiled by the research and development directorate of the NHS Executive, and I welcome their recognition of industry's issues and concerns. Moreover, I applaud the focus of the Clinical Research Working Group of the Pharmaceutical Industry Competitiveness Task Force, a joint initiative of government and industry that is seeking solutions for these …
The polymorphisms of Eotaxin 1 and CCR3 genes influence on serum IgE, Eotaxin levels and mild asthmatic children in Taiwan
Authors: T.‐N. Wang, W. Chiang, H.‐I. Tseng, Y.‐T. Chu, W.‐Y. Chen, N.‐H. Shih, Y.‐C. Ko
Journal: Allergy (2007)

Background: Asthma is a complex disorder, which is known to be affected by interactions between genetic and environmental factors. The human Eotaxin 1 and CCR3 attract eosinophils and Th2‐lymphocytes to migrate to the inflammatory foci that could represent a key mechanism in allergy and asthma. Objective: We hypothesized that Eotaxin1 gene Ala23Thr and A‐384 G, and CCR3 gene T51C polymorphisms are associated with plasma Eotaxin levels and predispose individuals to asthma pathogenesis. Methods: One hundred seventy‐eight hospital‐based asthmatic children and 277 community‐based controls aged from 5 to 12 years were recruited in southern Taiwan. Whole blood samples and questionnaires were collected. In this study, we addressed genetic effects of Eotaxin 1 and CCR3 genes on asthma, plasma IgE and Eotaxin 1 levels. Results: In comparison with subjects with Ala23Ala genotype, Ala23Thr polymorphism of the Eotaxin 1 gene showed a significant protective effect on asthma (AOR = 0.58, 95% CI = 0.37–0.92). We demonstrated that the mean Eotaxin 1 concentration was significantly higher in subjects with Ala23Ala than in subjects with Thr23Thr ( P = 0.005) or Ala23Thr ( P = 0.07), which showed a gene‐dose dependent relationship. But, we observed that the A‐384G polymorphism of Eotaxin 1 gene and T51C polymorphism of CCR3 gene are not associated with asthma. Conclusion: This study finding provide a strong evidence that Eotaxin 1 Thr23Thr homozygote has a protective effect on asthma and significantly decreases plasma Eotaxin 1 concentrations in asthmatics in Taiwan.
Prescription Medicines Code of Practice Authority investigates criticisms of advertisements
Authors: H. Simmonds
Journal: BMJ (1998)

Editor—Several letters recently have criticised the advertising of prescription medicines.1 Two points should be borne in mind. Firstly, a marketing authorisation for a medicine cannot be obtained unless the quality, safety, and efficacy of the medicine have been shown to the satisfaction of the United Kingdom Medicines Control Agency or the European Medicines Evaluation Agency. Secondly, all claims made for a product have to be consistent with the summary of product characteristics, which is approved as part …