tbuckley/cabot-search huggingface dataset:
Are the ABCD signs useful for the management of solar lentigo?
Authors: D. Moreno-Ramirez, L. Ferrandiz, F.M. Camacho
Journal: British Journal of Dermatology (2005)

Conflict of interest: None to declare. Sir, We have read with interest the recent case report of Stante et al.1 in this Journal regarding the benefit from dermoscopy for early detection of facial lentigo maligna (LM). These authors reported four cases of LM of the face whose identification depended on dermoscopic examination, as the lesions did not show ABCD clinical criteria for malignancy. In our practice at the Pigmented Lesion Clinic, Dermatology Department of the University Hospital Virgen Macarena, patients having clinically typical solar lentigo arising on the face may also present with dermoscopic criteria for early‐stage LM corresponding to the first stages of the progression proposed by Schiffner et al.2 (asymmetric follicular openings, slate‐grey dots and globules, first signs of rhomboidal structures and short streaks) (Fig. 1). These dermoscopic structures may lead to the diagnosis of early LM even when colour changes are not yet clinically evident. We therefore agree with the assertion that dermatologists should avoid the mistake of immediately excluding a diagnosis of malignancy when examining an ABCD‐negative pigmented skin lesion of the face. However, the source of our disagreement comes from the use of the ABCD rule for the management of solar lentigo, as in our opinion solar lentigo lesions are almost always ‘ABCD‐positive’.
The Impact of Medicare's Prospective Payment System on Wisconsin Nursing Homes-Reply
Authors: Carolyne K. Davis
Journal: JAMA (1987)

In Reply.—  I appreciate the opportunity to comment on the response by Sager et al to my editorial in the April 3, 1987, issue ofJAMA.  Dr Sager and his coauthors raise two issues regarding my review of their study. The first issue is the most serious and relates to the questions I raised about their finding that Wisconsin's institutionalized elderly Medicaid population experienced a 72% increase in the rate of hospitalization with the introduction of Medicare's hospital PPS. I wrote that a 72% increase for the institutionalized is so high as to suggest an artifact. Moreover, the findings in this study are not corroborated by any data from the Medicare program. This prompted me to question the utility of Medicaid claims data for analysis of Medicare hospitalizations. Because the subject is so important, I urged the authors to contact the Health Care Financing Administration to verify the figures presented in this study.
Antibody and T cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein.
Authors: V Karanikas, L A Hwang, J Pearson, C S Ong, V Apostolopoulos, H Vaughan, P X Xing, G Jamieson, G Pietersz, B Tait, R Broadbent, G Thynne, I F McKenzie
Journal: Journal of Clinical Investigation (1997)

Mucin 1 (MUC1) is a large complex glycoprotein that is highly expressed in breast cancer, and as such could be a target for immunotherapy. In mice, human MUC1 is highly immunogenic, particularly when conjugated to mannan, where a high frequency of CD8(+) MHC-restricted cytotoxic T lymphocytes is induced, accompanied by tumor protection. On this basis, a clinical trial was performed in which 25 patients with advanced metastatic carcinoma of breast, colon, stomach, or rectum received mannan-MUC1 in increasing doses. After 4 to 8 injections, large amounts of IgG1 anti-MUC1 antibodies were produced in 13 out of 25 patients (with antibody titers by ELISA of 1/320-1/20,480). Most of the antibodies reacted to the epitopes STAPPAHG and PAPGSTAP. In addition, T cell proliferation was found in 4 out of 15 patients, and CTL responses were seen in 2 out of 10 patients. Mannan-MUC1 can immunize patients, particularly for antibody formation, and to a lesser extent, cellular responses. It remains to be seen whether such responses have antitumor activity.
Transient Unilateral Reverse Ventilation/Perfusion Mismatch in a Patient with Lung Cancer
Authors: NAOYUKI WATANABE, TSUNEO HIRANO, TOMIO INOUE, MITSUOMI MATSUMOTO, NOBORU ORIUCHI, MADOKA TATENO, HIROSHI MATSUMOTO, YUKIO NAGAMACHI, KEIGO ENDO
Journal: Clinical Nuclear Medicine (1992)

The authors report a transient, unilateral reverse ventilation/perfusion (V/P) mismatch in a patient with squamous cell lung cancer. The right lung was well perfused but not ventilated (unilateral reverse V/P mismatch). However, lung imaging performed 3 days later demonstrated the absence of both perfusion and ventilation (V/P match). Reverse V/P mismatch may be a transient process.
When allergies complicate allergies
Authors: M. Wickman
Journal: Allergy (2005)

The ‘allergic march’ is a term used to describe an individual's progress from one clinical manifestation of allergy to another, with age. Not all sensitized children will join the allergic march, but it appears that individuals who do not join the allergic march have a greater risk of displaying symptoms of allergic disease in adulthood. Consequently, there is a need for early diagnosis of allergy in children. Immunoglobulin E (IgE) antibody quantification is increasingly used for this purpose. However, rather than making a diagnosis based on single positive IgE antibody results only, it may be more efficient to test a profile of airborne and food allergens and use the sum of IgE antibody concentrations ≥3.5 kU A /l in combination with the number of allergens that elicit positive results tests. Allergic diseases often co‐exist in patients, and the combination of several exposures at a given time (the allergen load) is related to disease severity. Therefore, a reduction of the allergen load is a key to successful treatment.
Externalization of endogenous annexin A5 participates in apoptosis of rat cardiomyocytes
Authors: V MONCEAU, Y BELIKOVA, G KRATASSIOUK, D CHARUE, E CAMORS, C COMMUNAL, P TROUVE, F RUSSOMARIE, D CHARLEMAGNE
Journal: Cardiovascular Research (2004)

Objective: Annexins are Ca2+-dependent phospholipid binding proteins. Externalized annexin A5 has been recently suggested to have a proapoptotic effect. Our aim was to determine whether annexin A5, which is intracellular in cardiomyocytes, could be translocated and/or externalized and play a role during the apoptotic process.
Molecular characterization of the vascular features of focal nodular hyperplasia and hepatocellular adenoma: A role for angiopoietin-1
Authors: Annette S. H. Gouw, Wenjiao Zeng, Marijke Buiskool, Inge Platteel, Marius C. van den Heuvel, Sibrand Poppema, Koert P. de Jong, Grietje Molema
Journal: Hepatology (2010)

Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are two hepatic nodular lesions of different etiologies. FNH, a polyclonal lesion, is assumed to be a regenerative reaction following a vascular injury, whereas HCA is a monoclonal, benign neoplastic lesion. In addition to features that are predominantly found in either FNH or HCA (e.g., dystrophic vessels in FNH and single arteries in HCA), FNH and HCA share morphological vascular abnormalities such as dilated sinusoids. We hypothesized that these anomalous vascular features are associated with altered expression of growth factors involved in vascular remodeling. This was based on reports of morphologically abnormal hepatic vasculature and nodular lesions in transgenic models of hepatocytic overexpression of angiopoietin-1 (Ang-1), a member of the angiopoietin family, which is crucially involved in vascular morphogenesis and homeostasis. We investigated gene and protein expression of members of the angiopoietin system and vascular endothelial growth factor A (VEGF-A) and its receptors in 9 FNH samples, 13 HCA samples, and 9 histologically normal livers. In comparison with normal samples, a significant increase in Ang-1 was found in FNH (P < 0.01) and HCA (P < 0.05), whereas no significant changes in Ang-2, receptor tyrosine kinase with immunoglobulin-like and EGF-like domains 2, VEGF-A, or vascular endothelial growth factor receptor 2 (VEGFR-2) were observed. Conclusion: Because of the different etiological contexts of a preceding vascular injury in FNH and a neoplastic growth in HCA, Ang-1 might exert different effects on the vasculature in these lesions. In FNH, it could predominantly stimulate recruitment of myofibroblasts and result in dystrophic vessels, whereas in HCA, it may drive vascular remodeling that produces enlarged vessels and arterial sprouting that generates single arteries. Hepatology 2010
Combinations of cytogenetics and international scoring system can predict poor prognosis in multiple myeloma after high‐dose chemotherapy and autologous stem cell transplantation
Authors: Yoshihiro Inamoto, Shingo Kurahashi, Nobuhiko Imahashi, Nobuaki Fukushima, Tatsuya Adachi, Tomohiro Kinoshita, Keitaro Tsushita, Koichi Miyamura, Tomoki Naoe, Isamu Sugiura
Journal: American Journal of Hematology (2009)

High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is a standard therapy for newly diagnosed multiple myeloma. Combinations of recently proposed prognostic factors such as cytogenetics and international scoring system (ISS) may be useful to predict prognosis after ASCT. This study evaluated 60 consecutive patients who underwent ASCT in four institutes. The median age of patients was 57 years old. Cytogenetic analyses of bone marrow at diagnosis detected metaphase abnormalities in 9 of 51 patients and interphase abnormalities in six of 35 patients (17p13 deletion, t(4;14) and t(14;16)). Seventeen patients had ISS stage 3 at diagnosis. Twenty-five patients who had any of these risk factors were defined as high risk. All patients were conditioned with high-dose melphalan. With a median follow-up of 3.4 years, overall survival and event-free survival at 3 years were significantly worse in high-risk patients (48% vs. 97%; P = 0.0005 and 16% vs. 37%; P = 0.038, respectively) despite the higher CR plus VGPR rate among high-risk patients. In addition, survival at 1 year after progression was significantly worse in high-risk patients despite salvage chemotherapy containing thalidomide (32% vs. 100%, P = 0.0001). Combinations of cytogenetics and ISS could readily predict prognosis. Quality of response is a poor surrogate marker for ultimate outcome. High-risk patients may need more effective treatment.
Man and Machine Calculating the Mind
Authors: Howard P. Rome
Journal: JAMA (1965)

<h3>To the Editor:—</h3> My colleagues, Drs. Swenson, Pearson, Brannick, and I regret Dr. Bersoff's misconstruction of the intent of our efforts. Perhaps it is his admitted "violence" in struggling to "muster... as rational and objective language as I can" which prevents him from seeing this study as an heuristic device with which to catalyze and not replace what we have said is the complex problem of communication among physicians, their patients, and their consulting colleagues. His pronouncement of anathema brings to mind the commentary of the late Norbert Weiner (<i>God and Golem Inc</i>, Cambridge, Mass: M.I.T. Press, 1964, p 5): "But even in the field of science, it is perilous to run counter to the accepted tables of precedence. On no account is it permissible to mention living beings and machines in the same breath.... If we adhere to all these taboos, we may acquire a great reputation as conservative
Abstract 5201: Distinctive distribution of expression of Lgr5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis
Authors: Kayoko Takeda, Ichiro Kinoshita, Yasushi Shimizu, Yoshihiro Matsuno, Toshiaki Shichinohe, Hirotoshi Dosaka-Akita
Journal: Cancer Research (2011)

Abstract Lgr5, an orphan G-protein coupled receptor and Wnt target gene, has been identified as a murine intestinal stem cell marker. To elucidate the role of Lgr5 during each stage of human colorectal tumorigenesis, we immunohistochemically analyzed 17 low-grade, 13 high-grade intraepithelial neoplasias and 30 adenocarcinomas. While there was only sporadic expression of Lgr5 at the crypt base in normal epithelia, the increased numbers of Lgr5-positive cells were found in most tumors, with clustering of the cells to form patches. An apparent difference in their distribution was observed among the different tumorigenesis stages. Lgr5 expression in luminal surface showed a negative association with the progressive grade of the tumors (p = 0.0004), while that in the lower crypt exhibited a positive association with grade (p = 0.0001). In adenocarcinomas, Lgr5 expression in the luminal surface was negatively associated with the pStage (p = 0.02), while it was almost invariably high in the lower crypt during advanced pStage disease. These results suggest that increases in putative stem cells with the Lgr5 expression occur early during colorectal tumorigenesis and that the shifts in their distribution towards the crypt base and/or invasive tumor front play a role in the development and progression of colorectal cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5201. doi:10.1158/1538-7445.AM2011-5201
Clindamycin for Acne-Reply
Authors: Gerald G. Krueger, Grant L. Christian
Journal: JAMA (1976)

In Reply.—  In reply to the letter of Dr Innes regarding our article, we would submit that we have drawn the two following conclusions: (1) Objective evidence has been submitted that clindamycin can be an alternative drug of value in the treatment of moderately severe acne. (2) There are indeed serious and significant side effects associated with its use, and careful and judicious use is indicated. As Dr Innes knows, there are numerous reports in medical literature regarding severe complications, namely pseudomembranous colitis, reported with the use of this drug. As is always true in clinical medicine, the physician must weigh all the evidence at hand in selecting the different therapeutic regimens available. Unfortunately, many physicians do not appreciate the severity of acne, eg, acute febrile ulcerative conglobate acne with polyarthralgias. 1,2 We recently had such a case that did not respond to high doses of tetracycline or erythromycin. There
Internet sites may encourage suicide
Authors: R. Dobson
Journal: BMJ (1999)

Internet sites advising on methods of suicide may be discouraging people from seeking psychiatric help, warns a report published this week.

More than 100000 sites about suicide now appear on the world wide web Many of these seem to condone suicide and forbid entry to anyone offering to dissuade users from taking their own lives, said the report's author, Dr Susan Thompson, senior house officer in child psychiatry at the Ealing, Hammersmith, and Fulham NHS Trust. Suicide is not illegal in the United Kingdom, but the 1951 Suicide Act prohibits others from encouraging the practice. This could provide the legal grounds for intervention, she suggested, arguing that these internet sites raise ethical issues about whether there should be …
Time and the observer: The where and when of consciousness in the brain
Authors: Daniel C. Dennett, Marcel Kinsbourne
Journal: Behavioral and Brain Sciences (1992)

Abstract We compare the way two models of consciousness treat subjective timing. According to the standard “Cartesian Theater” model, there is a place in the brain where “it all comes together,” and the discriminations in all modalities are somehow put into registration and “presented” for subjective judgment. The timing of the events in this theater determines subjective order. According to the alternative “Multiple Drafts” model, discriminations are distributed in both space and time in the brain. These events do have temporal properties, but those properties do not determine subjective order because there is no single, definitive “stream of consciousness,” only a parallel stream of conflicting and continuously revised contents. Four puzzling phenomena that resist explanation by the Cartesian model are analyzed: (1) a gradual apparent motion phenomenon involving abrupt color change (Kolers &amp; von Grünau 1976), (2) an illusion of an evenly spaced series of “hops” produced by two or more widely spaced series of taps delivered to the skin (Geldard &amp; Sherrick's “cutaneous rabbit” [1972]), (3) backwards referral in time, and (4) subjective delay of consciousness of intention (both reported in this journal by LIbet 1985a; 1987; 1989a). The unexamined assumptions that have always made the Cartesian Theater so attractive are exposed and dismantled. The Multiple Drafts model provides a better account of the puzzling phenomena, avoiding the scientific and metaphysical extravagances of the Cartesian Theater: The temporal order of subjective events is a product of the brain's interpretational processes, not a direct reflection of events making up those processes.
Strengthening Administrative Leadership in American Medical Schools
Authors: Harlow J. Heneman
Journal: New England Journal of Medicine (1966)

THERE is a need to strengthen administration in medical schools and for medical educators to provide the leadership and broad-gauge planning that have often been lacking in teaching centers. This observation and those that follow are based primarily upon conclusions drawn from 44 professional management studies of universities with medical schools and of hospitals and other organizations with medical-school affiliations.This paper emphasizes the general management responsibilities of the heads of medical schools or centers — whether the dean, the provost or the vice-president for medical affairs. Whatever his past experience or reputation may have been as a brilliant scholar . . .
THE PATHOLOGY OF TETANY.Read in the Section on Practice of Medicine, at the Forty-fifth Annual Meeting of the American Medical Association, held at San Francisco, June 5-8, 1894.
Authors: JOHN T. CARPENTER
Journal: JAMA (1894)

1. By way of introduction, a brief sketch of the literature and history of tetany may not be inappropriate, since very few observations have been published or papers written in this country upon the disease in question. The recognition of tetany (though Steinheim is credited by Stewart, of Montreal, as the first to give a true clinical description of tetany in 1830) dates from the memoirs of Dance, published in 1831 in the<i>Archives Générales de Médecine</i>, and entitled, "Observations on a Form of Intermittent Tetanus." The attention of the French physicians of this period having been directed to the new malady, various papers and memoirs were contributed by them from 1832 to 1855, elucidating its characteristic symptoms and conditions so thoroughly that it may be fairly conceded that to their labors is due all our present knowledge of this disorder. Several names were proposed to be given to this
Death masks unlimited.
Authors: I I Gibson
Journal: BMJ (1985)

Three years ago I visited the home of Canova, the sculptor, in Passagno in northern Italy.I grew rather tired of tombs decorated with lifesize lions or skeletons half opening the doors of death so retired to his study, where my friends found me and inquired what I was doing there.I said that I was reflecting on the vanity of human life and pointed out that from where I sat I could see the death mask of Canova and immediately beside it a Lawrence portrait, full of pomp and circumstance.This led to a considerable discussion on death masks, with the whole group participating, and I found myself saying that this was a part of history that was being lost and that someone should do something about it.I then realised there was only one person who would do something about it and started out on a search.Clues were scanty, but I now have knowledge of over 200 death masks and have seen and photographed many of these.I confine my searches to British masks and those of British subjects abroad.Ancient man was eager to preserve the facial features of the dead in order to preserve the soul.Medieval man, on the death of kings, queens, or other personages, made a masked, lifesize effigy that could be robed, carried through the streets, and displayed as indeed the Romans had done.In her book on Oliver Cromwell Lady Antonia Fraser gives one of the best descriptions I have read of such a display.The other main reason for the survival of death masks was nineteenth century phrenology, and this led to the great death mask collections.The finest of all is in Princeton University, New Jersey.It was made by Lawrence Hutton and based on a dustbin find of a collection, probably that of George Combe, Edinburgh lawyer, writer to the signet, and eminent phrenologist.Combe probably left some masks behind after a lecture tour in America.The collection of the Edinburgh Phreno- logical Society is in the care of the University of Edinburgh anatomy department.The Black Museum, New Scotland Yard, has a remarkable collection: most are from judicial executions but the two masks of Heinrich Himmler are startling.After I started my search there was a most exciting find of masks by Dundee Museum service.
Methods for Collection of Stool Samples
Authors: Ronald E. Myers
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 August 1988Methods for Collection of Stool SamplesRonald E. Myers, DSW, Paul F. Engstrom, MD, Alice A. Boyce, MARonald E. Myers, DSWSearch for more papers by this author, Paul F. Engstrom, MDSearch for more papers by this author, Alice A. Boyce, MASearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-3-252_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the study by Ahlquist and colleagues (1) on improving the technology used to collect stool samples for occult blood testing, the authors emphasized the importance of a collection device that reduces biochemical error and enjoys popular acceptance. A mechanism constructed of cardboard and a filter paper dish was described as effective on both counts. Another type of stool sampling approach, the HemaWipe System (Labeltape Meditect, Inc., Grand Rapids, Michigan; the name of this product has been changed to MEDI-CULT), also accomplishes these objectives (2).The HemaWipe System comprises three guaiacimpregnated, tissue-covered test pads. Each pad is...References1. AhlquistSchwartzIsaacsonEllefson DMBB. A stool collection device: the first step in occult blood testing. Ann Intern Med. 1988;108:609-12. LinkGoogle Scholar2. WardlawLevineSpiroJohnson SRHC. A new sample collecting and testing system for the detection of occult blood in feces. Conn Med. 1988;43:121-56. Google Scholar3. EngstromMyersAmselRimerRosan PRZBJ. Colorectal Cancer Screening in a Denned Population. Advances in Cancer Control V. New York City: Alan R. Liss, Inc. [In press]. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Ronald E. Myers, DSW; Paul F. Engstrom, MD; Alice A. Boyce, MAAffiliations: Fox Chase Cancer Center Philadelphia, PA 19111 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1988Volume 109, Issue 3Page: 252-252KeywordsHematologic tests ePublished: 1 December 2008 Issue Published: 1 August 1988 PDF downloadLoading ...
Problems of comprehensive shared diabetes care
Authors: D. Keable-Elliott, P. Kopelman, S. Ivinson
Journal: BMJ (1987)

require special training before undertaking this service.Again, diabetologists and ophthalmologists are strategically placed to provide education and training for all general practitioners who wish to do this work.If all three issues are addressed there is no reason why the problems of comprehensive shared diabetes care highlighted by Dr Day and col- leagues should not be overcome.This would allow consultant diabetologists to see patients with problems and