tbuckley/cabot-search huggingface dataset:
Brains and mobile phones
Authors: Michael Maier
Journal: BMJ (2006)

The novel coronavirus SARS-CoV-2 pandemic is a significant threat to public health, at the same time tuberculosis remains one of the top causes of death worldwide. Assessment of whether SARS-CoV-2 and Tbc co-infection influenced the course of the disease and increased Covid-19 mortality in the studied group. This study describes clinical characteristics of a series of COVID-19 patients with concurrent tuberculosis in Poland. 8 cases of Covid-19 co - infections with newly diagnosed or previously treated tuberculosis have been identified. Covid-19 was diagnosed on the basis of a positive PCR test The severity of the disease was assessed according to WHO. Most of the patients in the study group were men -87.5%, the mean age was 46. Newly diagnosed tuberculosis was found in 37.5%, while 62.5% of patients had previously been treated with Anti-Tb drugs. 75% of them presented the features of the mild course and 25% - the severe course, and no one was classified as critical. During hospitalization, only 3 patients required oxygen therapy. In the CT scan, 87.5% of patients presented a picture typical of tuberculosis, while no one developed changes typical for covid-19. In laboratory tests, 37.5% of patients had leukopenia, 87.5% of patients had elevated values of Il-6 (mean value 60,81 pg/ml, max 258pg/ml), elevated D-dimers in 75% of patients, elevated CRP in 100% of patients. None of the patients required HFNOT and no one was referred for ICU treatment. In the examined group of patients, no stay ended in death. No more severe course of the disease or increased mortality due to Covid-19 was observed in patients from the Polish population with coexisting active tuberculosis.
Palestinian doctor appeals for end to killing after losing three daughters
Authors: M. Sarig
Journal: BMJ (2009)

A prominent Palestinian gynaecologist who works in Israel and lives in Gaza, and who is a long term supporter of Arab-Israeli coexistence, lost three daughters in air attacks on his home at the end of last week.

Ezzeldeen Abu al-Aish, a gynaecologist at Sheba Medical Center, Tel HaShomer, in central Israel, had been trapped in Gaza, where his family lives, since the Israeli offensive began three weeks ago. On the afternoon of Friday 16 January he was at home with his family in the northern Gaza Strip when the house was hit by an Israel Defense Forces shell, killing three of his eight children and a niece. 

Dr Abu al-Aish, who has been giving frequent updates of the situation in Gaza to the Israeli media, has …
Development of Pulmonary Hypertension after Lung Volume Reduction Surgery
Authors: IRA L. WEG, LEONARD ROSSOFF, KERRI McKEON, L. MICHAEL GRAVER, STEVEN M. SCHARF
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

This prospective, longitudinal study was designed to assess the hemodynamic changes occurring in patients who undergo lung volume reduction surgery (LVRS). Patients with emphysema treated with LVRS underwent hemodynamic evaluation before and after surgery. The study group consisted of nine patients with an average age of 64.4 yr. FEV1 rose significantly from 0.64 preoperatively to 0.99 L postoperatively. After surgery, pulmonary artery (PA) systolic pressure rose to 47.9 ± 12.4 mm Hg, meeting criteria for development of pulmonary hypertension. In six patients, the elevation in PA pressure was attributed to an increase in the pulmonary vascular resistance, but for all nine patients the change was not statistically significant. The pulmonary artery occulsion pressure (PAOP) did not change postoperatively. There was no correlation of PAOP with global left ventricular ejection fraction. While preoperatively there was a negative correlation between symptoms (Mahler dyspnea index) and PA pressure, after surgery the change in PA pressures did not correlate with the change in symptoms (Mahler transitional dyspnea index). We concluded that development of pulmonary hypertension may occur after LVRS in patients whose symptomatic status improves and in whom this condition was not present preoperatively.
Changes of cytokeratin and involucrin expression in squamous cell carcinomas of the skin during progression to malignancy
Authors: S. WATANABE, E. ICHIKAWA, H. TAKAHASHI, F. OTSUKA
Journal: British Journal of Dermatology (2006)

Journal Article Changes of cytokeratin and involucrin expression in squamous cell carcinomas of the skin during progression to malignancy Get access S. WATANABE, S. WATANABE Department of Dermatology, Teikyo University School of Medicine, 11‐1, Kaga, 2 chome, Itabashi‐ku, Tokyo 173, Japan Search for other works by this author on: Oxford Academic Google Scholar E. ICHIKAWA, E. ICHIKAWA Department of Dermatology, Teikyo University School of Medicine, 11‐1, Kaga, 2 chome, Itabashi‐ku, Tokyo 173, Japan Search for other works by this author on: Oxford Academic Google Scholar H. TAKAHASHI, H. TAKAHASHI Department of Dermatology, Teikyo University School of Medicine, 11‐1, Kaga, 2 chome, Itabashi‐ku, Tokyo 173, Japan Search for other works by this author on: Oxford Academic Google Scholar F. OTSUKA F. OTSUKA School of Medicine, University of Tsukuba, Tsukuba, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 132, Issue 5, 1 May 1995, Pages 730–739, https://doi.org/10.1111/j.1365-2133.1995.tb00718.x Published: 01 May 1995 Article history Accepted: 15 August 1994 Published: 01 May 1995
Immunological Evaluation of Malignant Disease
Authors: Evan M. Hersh, Giora M. Mavligit, Jordan U. Gutterman
Journal: JAMA (1976)

CANCER immunology has developed as a distinct biomedical discipline during the last 20 years, and certain developments in this field are now applicable at the clinical level by the practicing physician. The field of cancer immunology includes studies of (1) immunodeficiency in the etiology, pathogenesis, and natural history of cancer, (2) immunosuppression induced by the various approaches to cancer treatment, (3) tumor-associated antigens and tumor-specific immunity to these antigens, (4) immunodiagnosis of cancer, and (5) cancer immunotherapy. The roles of immunocompetence and immunodeficiency in the pathogenesis and course of the malignant process make them important in estimating the prognosis of the cancer patient in clinical practice. Measurement of immunocompetence will have its most significant application in the development and evaluation of various approaches in immunotherapy. However, it is currently useful in evaluating the various conventional forms of cancer treatment which include surgery, radiation therapy, and chemotherapy. Tests of immunocompetence have
The Absorbency of Tampons-Reply
Authors: Sidney M. Wolfe
Journal: JAMA (1988)

<h3>In Reply.</h3> —Rome et al discuss several points that relate to three aspects of the lack of standardization of tampon absorbency, a situation that has existed for seven years, since the association between increased risk of toxic shock syndrome and increased tampon absorbency was first discovered. I agree with their conclusion that proper standardization of sampling prior to testing tampons for absorbency should require that tampon samples be taken from various retail shelves to represent the true variation in absorbency that might exist between different lots of the "same" tampon but that might be obscured if all samples were taken from the same lot. Another issue concerns standardization of the absorbency testing itself. Although there are demonstrated differences between tampon absorbencies using heparinized blood as opposed to saline, the impossibility of standardizing heparinized blood because it would come from different sources precludes its use and favors the saline solution, as
PSYCHIATRY AND THE SCIENCE OF MAN
Authors: FRANCIS J. BRACELAND
Journal: American Journal of Psychiatry (1957)

As I close this dissertation, I am aware that I have ranged far afield, with thoughts extending lightly in the clouds; yet all of me is planted solidly with my respected colleagues in the mental hospital, the scene of our labors. Earl Bond spoke feelingly of the necessity of giving the hospital psychiatrist a place in the scheme of things and he asked that all scientific day dreams be checked by the facts which the hospital psychiatrist has in his possession. I feel that my score in that test would not be high and yet it is necessary at times to soar from the hard facts of too many sick people, too little help, too little of everything furnished too late. I know the futility of asking overworked and fatigued men to look up from their labors in order to see something grand in the overall scheme of things; yet look up we must and, when we do, we can better serve not only the progress of psychiatry, but also the progress of man to a fuller and better life. If the science of man brings enlightenment to psychiatry, psychiatry can repay this debt amply by keeping in mind the great dignity of man and what human nature really is. The psychiatrist, even more than others, is entitled to make his own the words of the poet, Terence:
Prognostic Implications of Silent Myocardial Ischemia
Authors: Carl J. Pepine
Journal: New England Journal of Medicine (1996)

Reducing morbidity and mortality from coronary artery disease continues to be a major challenge. Many patients with coronary artery disease are asymptomatic or nearly so for long periods, and even when symptoms are present, their severity alone does not predict the outcome. Objective markers associated with an adverse outcome have been identified. They include exercise-induced electrocardiographic (ECG) changes and abnormalities on myocardial-perfusion scans and studies of ventricular wall motion. These abnormalities usually occur in the absence of symptoms but are related to myocardial ischemia — hence, the term “silent ischemia.” It seems more appropriate, however, simply to use the term . . .
Multidisciplinary Management of Lung Cancer
Authors: Alexander Spira, David S. Ettinger
Journal: New England Journal of Medicine (2004)

Despite years of research, the five-year survival rate among patients with lung cancer is a mere 14 percent. Lung cancer is divided into two major types — non–small-cell lung cancer and the more aggressive small-cell lung cancer. This review considers the treatment of each type in the framework of multidisciplinary management and recent clinical trials.
Time Course of Vascular Resistance and Venous Oxygen Changes following Brief Tetanus of Dog Skeletal Muscle
Authors: DAVID E. MOHRMAN, JAMES R. CANT, HARVEY V. SPARKS
Journal: Circulation Research (1973)

The time courses of vascular resistance and venous blood oxygen (O 2 ) saturation following a brief tetanus of isolated dog calf muscle were studied during free-flow (constant-pressure), high constant-flow (&gt;30 ml/100 g min -1 ), and low constant-flow (&lt;24 ml/100 g min -1 ) perfusion. A monophasic decrease in resistance followed a 1-second tetanus during either free-flow or high constant-flow perfusion. The transient decrease in vascular resistance during high constant-flow perfusion returned to control before the return of the decrease in end-capillary oxygen tension. Thus, it seems unlikely that the vascular response to a brief tetanus during free-flow or high constant-flow perfusion was controlled by a factor related to oxidative metabolism. A biphasic resistance response followed a brief tetanus during low constant-flow perfusion. This vascular response had a longer duration than the response during free-flow or high constant-flow perfusion. It returned to control with approximately the same time course as that for tissue O 2 consumption and could therefore be controlled by factors related to oxidative metabolism. These findings support the hypothesis that exercise hyperemia is due to multiple factors. Moreover, they indicate that, under the conditions of free-flow perfusion or high constant-flow perfusion, the vascular response to a brief tetanus is not solely controlled by factors directly associated with tissue oxidative metabolism.
Does Clopidogrel Each Day Keep Stent Thrombosis Away?
Authors: Dean J. Kereiakes
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Unapproved and Off-Label Use of Drugs in a Children's Hospital
Authors: Geert W. `t Jong, Arnold G. Vulto, Matthijs de Hoog, Kirsten J.M. Schimmel, Dick Tibboel, John N. van den Anker
Journal: New England Journal of Medicine (2000)

Effect of Eliminating Compensation for Pain and Suffering on the Outcome of Insurance ClaimsTo the Editor: The findings of Cassidy et al. (April 20 issue) 1 suggest that radical changes are needed in the tort system of automobile insurance that is common throughout the United States, in which injured claimants can sue for pain and suffering caused by another driver's negligence.Cassidy et al. examined the time to closure of a claim for claimants injured in motor vehicle collisions in Saskatchewan, Canada, during the six months before January 1, 1995, when a tort system was in effect, and in the two consecutive sixmonth periods after that date, when no-fault insurance was implemented.Under the no-fault system, claimants could no longer claim compensation for pain and suffering.The time to closure of claims was reduced by 54 percent during the no-fault period.The authors conclude that the reduction in the duration of whiplash injuries under the no-fault system was due to the absence of the financial incentive that is inherent in the tort system.Cassidy et al. base their conclusions on the assumption that when an injury claim was closed under the no-fault system, the claimant had recovered from his or her injuries.The only support that Cassidy et al. provide for the assumption that recovery from whiplash coincided with the closure of the claim is a 1995 monograph by the Quebec Task Force on Whiplash-Associated Disorders, in which the authors equated the cessation of time-loss payments with recovery. 2e have criticized the use of time-loss payments as a proxy for recovery in that study, since no data were collected on the symptoms, amount or type of treatment, or degree of 1.
Effect of Major Disaster on a Virology Research Laboratory
Authors: Elmer T. Feltz, Robert McAlister
Journal: JAMA (1964)

IT CAN HAPPEN, and quite suddenly. Many of us have thought about the consequences of a violent disruption of our routine existence in a modern American community. Few of us have come face to face with a disaster that has instantly halted a way of life, shocked its citizens, and for purposes of this discussion, battered the scientist's pride and joy, his research laboratory. Discussion of the problems, dilemmas, and decisions that arise at such a time may be of value to the uninitiated. The stimulus for this report was an earthquake, rated at 8.4 on the Richter scale, which occurred in Alaska at 5:36 PM, March 27, 1964. The following is a summary of consequent experiences in the Virology Research Laboratory, Section of Epidemiology, Arctic Health Research Center, US Public Health Service, located in the city of Anchorage. The area was without communications or utilities for 36 hours. Power was restored to the laboratory in 48 hours, water and heat in 72 hours. Temperatures in the city ranged in the mid-twenties. Snow was falling intermittently and continued to fall in
Ultraviolet exposure patterns of Irish and Danish gardeners during work and leisure
Authors: E. Thieden, S.M. Collins, P.A. Philipsen, G.M. Murphy, H.C. Wulf
Journal: British Journal of Dermatology (2005)

Journal Article Ultraviolet exposure patterns of Irish and Danish gardeners during work and leisure Get access E. Thieden, E. Thieden Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, DK‐2400 Copenhagen, Denmark *Department of Dermatology, Beaumont Hospital, Dublin, Ireland Elisabeth Thieden. E‐mail: et01@bbh.hosp.dk Search for other works by this author on: Oxford Academic Google Scholar S.M. Collins, S.M. Collins Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, DK‐2400 Copenhagen, Denmark *Department of Dermatology, Beaumont Hospital, Dublin, Ireland Search for other works by this author on: Oxford Academic Google Scholar P.A. Philipsen, P.A. Philipsen Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, DK‐2400 Copenhagen, Denmark *Department of Dermatology, Beaumont Hospital, Dublin, Ireland Search for other works by this author on: Oxford Academic Google Scholar G.M. Murphy, G.M. Murphy Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, DK‐2400 Copenhagen, Denmark *Department of Dermatology, Beaumont Hospital, Dublin, Ireland Search for other works by this author on: Oxford Academic Google Scholar H.C. Wulf H.C. Wulf Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, DK‐2400 Copenhagen, Denmark *Department of Dermatology, Beaumont Hospital, Dublin, Ireland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 4, 1 October 2005, Pages 795–801, https://doi.org/10.1111/j.1365-2133.2005.06797.x Published: 01 October 2005 Article history Accepted: 25 March 2005 Published: 01 October 2005
Lack of synergy by mixtures of weakly estrogenic hydroxylated polychlorinated biphenyls and pesticides.
Authors: K F Arcaro, D D Vakharia, Y Yang, J F Gierthy
Journal: Environmental Health Perspectives (1998)

We examined the estrogenicity of binary mixtures of the hydroxylated polychlorinated biphenyls (OHPCBs) 2,4,6-trichloro-4'-biphenylol (2,4,6-TCB-4'-OH) and 2,3,4,5-tetrachloro-4'-biphenylol and the pesticides endosulfan and dieldrin. The OHPCBs and pesticides were tested in both the MCF-7 focus assay and a competitive estrogen-receptor binding assay. Although the individual OHPCBs were estrogenic in both assays, there was no synergy when they were combined at various concentrations as equimolar mixtures. Of the pesticides, only endosulfan was estrogenic. Its weak estrogenicity was seen only in the MCF-7 focus assay at the highest concentration tested--10 microM. There was no synergy of the equimolar mixture of pesticides. To determine whether OHPCBs might respond synergistically when combined with the natural estrogen 17-beta-estradiol (E2), we tested various concentrations of 2,4,6-TCB-4'-OH in the MCF-7 focus assay in combination with physiologically relevant concentrations of E2. There was no synergy between 2,4,6-TCB-4'-OH and E2. Pretreatment for 3 or 7 days with 2,4,6-TCB-4'-OH had no effect on subsequent foci induced by a concentration of 2,4,6-TCB-4'-OH and E2. Although our results showing no synergy between the pesticides or the OHPCBs are in contrast to a recent report that binary mixtures of these same compounds produce synergistic responses in estrogen-sensitive assays, they are in agreement with the results from other assays showing a lack of synergy. Considering all results, it appears that synergy of these weakly estrogenic compounds acting through the estrogen receptor is unlikely.
Myocardial Infarction: Its Presentation, Pathogenesis and Treatment
Authors: Ahmed Kutty
Journal: JAMA (1984)

This book represents a conspectus of current knowledge and practice at Green Lane Hospital, under the eminent and able guidance of Dr Norris, an authority on the subject of myocardial infarction. The author's broad experience in the field of clinical, epidemiologic, and experimental cardiology is evident throughout the book, which is divided into three parts. Part 1 is an up-to-date, comprehensive treatment of the natural history of myocardial infarction and stresses clinical evidence to support the concepts presented. That myocardial infarction is a dynamic, and not an all-or-none, clinical phenomenon is pivotal. The chapter on arrhythmias is an excellent summary of current practice, ably coauthored by Dr B. N. Singh. Treatment of myocardial infarction, in six concise, well-documented chapters, comprises part 2 of the book. The author's extensive experience with out-of-hospital coronary care is effectively conveyed in the first chapter. Discussion of convalescence and long-term treatment of the patient who
The Reporting of Venereal Disease
Authors: O. Lynn Deniston
Journal: JAMA (1968)

To the Editor:—  I am deeply disturbed by the article and the editorial concerning the reporting of venereal disease inThe Journal( 202 :941, 1967).  Cleere and associates begin by establishing that reporting is required by law in each of the 50 states of America. They proceed to cite data which indicate there is considerable noncompliance with these laws, and conclude that most physicians comply some of the time. They then suggest this is due to lack of information, understanding and trust. The recommended solution is for public health workers to provide information about the reasons for reporting and demonstrations of trustworthiness.  The point that disturbs me is that both the article and the editorial suggest that physicians should be allowed to decide when and under what circumstances they will comply with a law which requires reporting of venereal disease. If this is accepted, to what extent can the principle
Hyperventilation Syndrome-Reply
Authors: José C. Missri
Journal: JAMA (1980)

<h3>In Reply.—</h3> We certainly agree with Dr Record that hypophosphatemia is potentially dangerous. Indeed, a recent report<sup>1</sup>suggests still another serious effect—severe, but, fortunately, reversible heart failure. Perhaps we did not emphasize this enough, but our review was not concerning the effects of severe, chronic alkalosis, but, rather, hyperventilation occurring in the absence of known organic disease. While phosphate levels in these patients can be acutely depressed,<sup>2</sup>presumably phosphate concentration returns rather promptly to normal once hyperventilation ceases. We know of no data defining phosphate levels in chronic, sustained hyperventilation, but this is rare in our experience, anyway. The majority of our patients hyperventilate for brief periods only and feel relatively well in between. Dr Martin raises some interesting questions. We never stated that all anxious people hyperventilate and certainly made no claim to know why some do and others do not. Nor do we think our statement