tbuckley/cabot-search huggingface dataset:
Metabolism of Vitamin D3-3H in Vitamin D-Resistant Rickets and Familial Hypophosphatemia*
Authors: Louis V. Avioli, T. Franklin Williams, Judith Lund, Hector F. DeLuca
Journal: Journal of Clinical Investigation (1967)

The fate of an intravenous dose of tritiated vitamin D(3) was studied in seven normal subjects, four children with vitamin D-resistant rickets, and four adults with a familial history of vitamin D-resistant rickets and persistent hypophosphatemia. An abnormal metabolism of vitamin D in vitamin D-resistant rickets was defined and characterized by a decrease in the plasma fractional turnover rate, a marked increase in plasma water-soluble metabolites, and a relative decrease in the conversion of vitamin D to a polar, biologically active metabolite. Alterations in vitamin D metabolism in the adults with persistent hypophosphatemia were similar but less severe than those of affected children with vitamin D-resistant rickets. It is tentatively concluded that the abnormalities in vitamin D metabolism documented in patients with vitamin D-resistant rickets and familial hypophosphatemia may account for the observed osseous and biochemical changes.
Drug-Related Hepatitis
Authors: Susumu Imoto, Hidetoshi Matsumoto, Masahiro Fujii
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 July 1979Drug-Related HepatitisSUSUMU IMOTO, M.D., HIDETOSHI MATSUMOTO, M.D., MASAHIRO FUJII, M.D.SUSUMU IMOTO, M.D.Search for more papers by this author, HIDETOSHI MATSUMOTO, M.D.Search for more papers by this author, MASAHIRO FUJII, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-1-129_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We have read with interest the paper by Miller and associates on halothane hepatitis in the August 1978 issue.During the last 6 years, we have seen 35 patients with a drug-induced hepatitis at Shinko Hospital, Kobe, Japan. Nine had a severe hepatic lesion with bridging necrosis as determined in liver biopsy specimens during the acute episode. Two of these nine were males and seven were females. Drugs were identified by cautious rechallenge in eight and by an in-vitro test in one.N-Methyl carbamate was the causative drug in four and mefenamic acid, kanamycin, pyrazinamide, difenamizole, and...References1. MILLERDWYERKLATSKIN DJG. Halothane hepatitis: benign resolution of a severe lesion. Ann Intern Med. 1978;89:212-5. LinkGoogle Scholar2. BOYERKLATSKIN JG. Pattern of necrosis in acute viral hepatitis: prognostic value of bridging (subacute hepatic necrosis). N Engl J Med. 1970;283:1063-71. CrossrefMedlineGoogle Scholar3. FUJIIYAMAMOTOWAKISAKA MTG. Diagnosis of diffuse liver disease based on the estimation of hepatic effective blood flow and volume, and on the findings of liver RI image using radioactive colloid. In: Proceedings of the First World Congress on Nuclear Medicine. 1974:492. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SUSUMU IMOTO, M.D.; HIDETOSHI MATSUMOTO, M.D.; MASAHIRO FUJII, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNonsteroidal Antiinflammatory Drugs and Leukotriene Receptor AntagonistsNSAID-INDUCED HEPATOTOXICITYAntimicrobial DrugsHEPATOTOXICITY OF ANALGESICS AND ANTI-INFLAMMATORY AGENTSBlood Markers of Alcoholic Liver DiseasePlasma Glutamate Dehydrogenase: Clinical Application in Patients With Alcoholic Liver Disease 1 July 1979Volume 91, Issue 1Page: 129-129KeywordsBiopsyDrugsHepatitisHepatitis ALesionsLiverNecrosis ePublished: 1 December 2008 Issue Published: 1 July 1979 PDF downloadLoading ...
Plasma-Derived C1 Inhibitor Concentrate Did Not Increase the Risk of Thromboembolism in Patients with Hereditary Angioedema Due to C1-Inhibitor Deficiency – a Long-Term Survey
Authors: Henriette Farkas, Kinga Viktoria Kohalmi, Nora Veszeli, Zsuzsanna Zotter, Katalin Varnai, Lilian Varga
Journal: Journal of Allergy and Clinical Immunology (2015)
US institute list eight services for women that all insurers should provide
Authors: B. Roehr
Journal: BMJ (2011)

Basic preventive health services should include eight interventions specific to women that were identified as gaps in coverage, according to a study from the US Institute of Medicine (IOM).

Health insurance plans must begin to provide basic prevention services free of additional charge under healthcare reform provisions of the 2010 Affordable Care Act. The Department of Health and Human Services requested the study before making its final rules on what package of services must be covered under that provision of the law.

It asked the IOM to identify gaps in existing guidelines for prevention services as outlined by standing advisory committees to the department, and also to recommend …
Histopathology, hormone products, and clinicopathological profile of endocrine tumors of the upper small intestine: A study of 44 cases
Authors: Carlo Capella, Cristina Riva, Guido Rindi, Fausto Sessa, Luciana Usellini, Annamaria Chiaravalli, Luciano Carnevali, Enrico Solcia
Journal: Endocrine Pathology (1991)
MECKEL'S DIVERTICULUM AND INTESTINAL OBSTRUCTION
Authors: HAROLD L. FOSS
Journal: JAMA (1923)

There are surgeons of wide experience who have never seen that curious embryologic remnant referred to as Meckel's diverticulum. Certainly, many have never had occasion to remove it, so infrequently is it present and so rarely involved in disease. Yet most surgeons whose work necessitates their performing a large number of laparotomies will find this organ the seat of inflammation or the cause of intestinal obstruction at least once or twice in every thousand or fifteen hundred patients suffering from abdominal symptoms and on whom they are called to operate. When it is found, the discovery usually excites the interest of all those who surround the table and, as a rule, is considered sufficiently remarkable to prompt the calling in of all those in immediate touch with the operating room that they may not miss the opportunity of viewing this anatomic curiosity.  Meckel's diverticulum usually occurs as a finger-like projection
En Face Enhanced-Depth Swept-Source Optical Coherence Tomography Features of Chronic Central Serous Chorioretinopathy
Authors: Daniela Ferrara, Kathrin J. Mohler, Nadia Waheed, Mehreen Adhi, Jonathan J. Liu, Ireneusz Grulkowski, Martin F. Kraus, Caroline Baumal, Joachim Hornegger, James G. Fujimoto, Jay S. Duker
Journal: Ophthalmology (2013)
355 Telomerase gene rescue promotes hepatocarcinogenesis in the context of p53- and telomere-dysfunction by limiting chromosomal instability
Authors: A. Lechel, H. Holstege, Y. Begus, A. Schienke, K. Kamino, R. Geffers, U. Lehmann, J. Buer, M.P. Manns, S. Kubicka, P. Schirmacher, J. Jonkers, K.L. Rudolph
Journal: Journal of Hepatology (2006)
Assessment of left ventricular asynchrony using volume—time curves of 16 segments by real‐time 3 dimensional echocardiography: Comparison with tissue Doppler imaging
Authors: Seong‐Mi Park, Ki‐Chang Kim, Min‐Jae Jeon, Chang‐Kun Lee, Dae‐Hyeok Kim, Keum‐Soo Park, Woo‐Hyung Lee, Jun Kwan
Journal: European Journal of Heart Failure (2006)
293. Optimizing the Efficacy of Spliceosome-Mediated RNA Trans-Splicing (SMaRT™) for Suicide Gene Therapy of Cervical Cancer
Authors: Michael Patrick, M. Puttaraju, Janet DiPasquale, Jesse Quintero, Yanping Yang, Mariano A. Garcia-Blanco, Lloyd G. Mitchell, Ed Otto, Carl C. Baker
Journal: Molecular Therapy (2005)

SMaRT|[trade]| is a platform technology that has the ability to reprogram genetic information at the mRNA level. SMaRT involves the trans-splicing of a pre-trans-splicing molecule (PTM) to a target pre-mRNA. PTMs are RNAs that are designed to contain a binding domain (BD) complementary to a target pre-mRNA, splice elements necessary for efficient and specific trans-splicing and the coding domain. Target specificity is obtained by tethering the PTM to the target pre-mRNA through the BD in the PTM. SMaRT can be used to replace or repair 5' exon(s), internal exon(s), and 3' terminal exon(s) and to make chimeric mRNAs. We are investigating the use of SMaRT to specifically target the expression of a therapeutic molecule to cervical cancer, which is associated with oncogenic human papillomaviruses (HPVs). We have designed HPV-specific PTMs that target the pre-mRNAs encoding E6 and E7 oncoproteins and have shown efficient trans-splicing to HPV pre-mRNAs. We are using this system to study the factors that affect trans-splicing efficiency and specificity. Previously, we have shown that the BD confers both target specificity as well as splice site specificity. Trans-splicing efficiency is very high (80%) in cotransfection experiments and the amount of trans-spliced product is directly proportional to the amount of target over at least a 300-fold range. The efficiency of trans-splicing to endogenous targets is generally 10-fold lower. We investigated SMaRT by cotransfecting GFP and PTM expression vectors into cells stably expressing a mini-gene HPV pre-mRNA target and sorting cells for high and low GFP expression using flow cytometry. Those cells that expressed the most GFP also expressed the highest levels of PTM and had higher levels of trans-splicing (|[sim]|17%). In contrast, trans-splicing efficiency in low GFP-expressing cells was only 4%. We conclude from these experiments that trans-splicing to endogenous targets can be improved significantly with efficient delivery and high expression of PTMs. Cervical cancer cell lines such as CaSki and SiHa express endogenous HPV-16 pre-mRNAs, but have been refractory to efficient transfection. We have now generated recombinant adenoviral vectors expressing HPV PTMs and are using them to efficiently deliver PTMs to cervical cancer cells. Experiments are in progress to assess trans-splicing efficiency and potential therapeutic effects as a function of multiplicity of infection.
ANTICARDIOLIPIN ANTIBODIES: DETECTION BY RADIOIMMUNOASSAY AND ASSOCIATION WITH THROMBOSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: E.N. Harris, M.L. Boey, C.G. Mackworth-Young, A.E. Gharavi, B.M. Patel, S. Loizou, G.R.V. Hughes
Journal: The Lancet (1983)
Exon Skipping of Hepatic APOB Pre-mRNA With Splice-switching Oligonucleotides Reduces LDL Cholesterol In Vivo
Authors: Petra Disterer, Raya Al-Shawi, Stephan Ellmerich, Simon N Waddington, James S Owen, J Paul Simons, Bernard Khoo
Journal: Molecular Therapy (2013)

Familial hypercholesterolemia (FH) is a genetic disorder characterized by extremely high levels of plasma low-density lipoprotein (LDL), due to defective LDL receptor-apolipoprotein B (APOB) binding. Current therapies such as statins or LDL apheresis for homozygous FH are insufficiently efficacious at lowering LDL cholesterol or are expensive. Treatments that target APOB100, the structural protein of LDL particles, are potential therapies for FH. We have developed a series of APOB-directed splice-switching oligonucleotides (SSOs) that cause the expression of APOB87, a truncated isoform of APOB100. APOB87, like similarly truncated isoforms expressed in patients with a different condition, familial hypobetalipoproteinemia, lowers LDL cholesterol by inhibiting very low–density lipoprotein (VLDL) assembly and increasing LDL clearance. We demonstrate that these "APO-skip " SSOs induce high levels of exon skipping and expression of the APOB87 isoform, but do not substantially inhibit APOB48 expression in cell lines. A single injection of an optimized APO-skip SSO into mice transgenic for human APOB resulted in abundant exon skipping that persists for >6 days. Weekly treatments generated a sustained reduction in LDL cholesterol levels of 34–51% in these mice, superior to pravastatin in a head-to-head comparison. These results validate APO-skip SSOs as a candidate therapy for FH. Familial hypercholesterolemia (FH) is a genetic disorder characterized by extremely high levels of plasma low-density lipoprotein (LDL), due to defective LDL receptor-apolipoprotein B (APOB) binding. Current therapies such as statins or LDL apheresis for homozygous FH are insufficiently efficacious at lowering LDL cholesterol or are expensive. Treatments that target APOB100, the structural protein of LDL particles, are potential therapies for FH. We have developed a series of APOB-directed splice-switching oligonucleotides (SSOs) that cause the expression of APOB87, a truncated isoform of APOB100. APOB87, like similarly truncated isoforms expressed in patients with a different condition, familial hypobetalipoproteinemia, lowers LDL cholesterol by inhibiting very low–density lipoprotein (VLDL) assembly and increasing LDL clearance. We demonstrate that these "APO-skip " SSOs induce high levels of exon skipping and expression of the APOB87 isoform, but do not substantially inhibit APOB48 expression in cell lines. A single injection of an optimized APO-skip SSO into mice transgenic for human APOB resulted in abundant exon skipping that persists for >6 days. Weekly treatments generated a sustained reduction in LDL cholesterol levels of 34–51% in these mice, superior to pravastatin in a head-to-head comparison. These results validate APO-skip SSOs as a candidate therapy for FH.
Alternative Pathways for Training the General Internist and the Medical Subspecialist
Authors: Laurence E. Earley
Journal: Annals of Internal Medicine (1992)

Considerable attention is being directed from within the discipline of internal medicine to a perceived need for changes in the curriculum for postgraduate training of the internist. Much of this attention has been focused on the training required to properly prepare the general internist for the evolving system of health care. A proposal is presented to change the pattern of training of both the general internist and the medical subspecialist. After 2 years of core training, the general internist would enter 2 additional years of training that would include new material and additional experience in areas such as ambulatory and continuity care. After the core experience, the subspecialist would begin training in the subspecialty. The general internist would be certified as such, and the subspecialist would be certified only in the subspecialty. The proposal is based on the assumptions that 1) more general physicians are needed to meet the nation's health care needs; 2) more time will be required to properly train the general internist; 3) all of the additional and expanded training experiences for the generalist are not essential for training the subspecialist; and 4) the generalists of the future will not come from the ranks of subspecialists. The training needs of the general internist and the subspecialist should be viewed as separate, and curriculum changes should be considered without the restrictions of current patterns of training.
Oncogenic Osteomalacia and Inappropriate Antidiuretic Hormone Secretion Due to Oat-Cell Carcinoma
Authors: HARRIS C. TAYLOR
Journal: Annals of Internal Medicine (1984)

The syndrome of tumor-induced osteomalacia has been previously thought to occur only in association with mesenchymal tumors, although one report has linked prostatic carcinoma with the syndrome. We report the case of a patient who presented first with the clinical and biochemical features of the syndrome of inappropriate antidiuretic hormone secretion, and then oncogenic osteomalacia. The first syndrome was characterized by headaches, nausea, and vomiting; serum sodium determinations ranged between 107 and 118 meq/L with simultaneous urine spot sodium concentrations of 100 to 116 meq/L. The circulating antidiuretic hormone level was markedly elevated to 261.5 µU/mL. The osteomalacia was discovered incidentally when depressed serum phosphorus levels of 1.2 to 1.7 mg/dL were noted in association with 24-hour urine phosphorus excretion exceeding 1000 mg/24 h. Undecalcified tetracycline-labeled bone biopsy samples confirmed oncogenic osteomalacia. Only afterward was a small-cell carcinoma of the lung identified as the likely source of both of these syndromes.
Relation of perfusion defects observed with myocardial contrast echocardiography to the severity of coronary stenosis: Correlation with thallium-201 single-photon emission tomography
Authors: B. Jorge Cheirif, Ranley M. Desir, Roberto Bolli, John J. Mahmarian, William A. Zoghbi, Mario S. Verani, Miguel A. Quiñones
Journal: Journal of the American College of Cardiology (1992)
Generation, selection and preclinical characterization of an Fc-optimized FLT3 antibody for the treatment of myeloid leukemia
Authors: M Hofmann, L Große-Hovest, T Nübling, E Pyż, M L Bamberg, S Aulwurm, H-J Bühring, K Schwartz, S P Haen, K Schilbach, H-G Rammensee, H R Salih, G Jung
Journal: Leukemia (2012)
Prevention and early detection of vascular complications of diabetes
Authors: Sally M Marshall, Allan Flyvbjerg
Journal: BMJ (2006)

Diabetes reduces life expectancy by five to 10 years.Premature cardiovascular disease is the most common cause of morbidity and mortality, but the microvascular complications specific to diabetes (box 1) are also contributory factors.Diabetes is the most common reason for renal replacement therapy worldwide, the most common cause of blindness in the under 65s, and the most common cause of non-traumatic amputation.With our current knowledge, most of these devastating events could be prevented or delayed, or their impact minimised.This review focuses on the prevention, early detection, and initial management of the vascular complications of diabetes in adults.
Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study
Authors: Jack Cuzick, Gregory P Swanson, Gabrielle Fisher, Arthur R Brothman, Daniel M Berney, Julia E Reid, David Mesher, VO Speights, Elzbieta Stankiewicz, Christopher S Foster, Henrik Møller, Peter Scardino, Jorja D Warren, Jimmy Park, Adib Younus, Darl D Flake, Susanne Wagner, Alexander Gutin, Jerry S Lanchbury, Steven Stone
Journal: The Lancet Oncology (2011)

Optimum management of clinically localised prostate cancer presents unique challenges because of the highly variable and often indolent natural history of the disease. To predict disease aggressiveness, clinicians combine clinical variables to create prognostic models, but the models have limited accuracy. We assessed the prognostic value of a predefined cell cycle progression (CCP) score in two cohorts of patients with prostate cancer. We measured the expression of 31 genes involved in CCP with quantitative RT-PCR on RNA extracted from formalin-fixed paraffin-embedded tumour samples, and created a predefined score and assessed its usefulness in the prediction of disease outcome. The signature was assessed retrospectively in a cohort of patients from the USA who had undergone radical prostatectomy, and in a cohort of randomly selected men with clinically localised prostate cancer diagnosed by use of a transurethral resection of the prostate (TURP) in the UK who were managed conservatively. The primary endpoint was time to biochemical recurrence for the cohort of patients who had radical prostatectomy, and time to death from prostate cancer for the TURP cohort. After prostatectomy, the CCP score was useful for predicting biochemical recurrence in the univariate analysis (hazard ratio for a 1-unit change [doubling] in CCP 1·89; 95% CI 1·54–2·31; p=5·6×10−9) and the best multivariate analysis (1·77, 1·40–2·22; p=4·3×10−6). In the best predictive model (final multivariate analysis), the CCP score and prostate-specific antigen (PSA) concentration were the most important variables and were more significant than any other clinical variable. In the TURP cohort, the CCP score was the most important variable for prediction of time to death from prostate cancer in both univariate analysis (2·92, 2·38–3·57, p=6·1×10−22) and the final multivariate analysis (2·57, 1·93–3·43; p=8·2×10−11), and was stronger than all other prognostic factors, although PSA concentration also added useful information. Heterogeneity in the hazard ratio for the CCP score was not noted in any case for any clinical variables. The results of this study provide strong evidence that the CCP score is a robust prognostic marker, which, after additional validation, could have an essential role in determining the appropriate treatment for patients with prostate cancer. Cancer Research UK, Queen Mary University of London, Orchid Appeal, US National Institutes of Health, and Koch Foundation.
Response: Re: Second Cancers Among 104760 Survivors of Cervical Cancer: Evaluation of Long-Term Risk
Authors: A. K. Chaturvedi, E. A. Engels, E. S. Gilbert, B. E. Chen, H. Storm, C. F. Lynch, P. Hall, F. Langmark, E. Pukkala, M. Kaijser, M. Andersson, S. D. Fossa, H. Joensuu, J. D. Boice, R. A. Kleinerman, L. B. Travis
Journal: JNCI Journal of the National Cancer Institute (2008)
Wasted drugs in HIV infection and AIDS.
Authors: S. Steel, R. George
Journal: BMJ (1992)

future.The development of a coherent strategy across all sectors following a health lead has been shown to be possible in Wales.4NHS regions in the United Kingdom may have the option of looking towards Brussels rather than Whitehall for health policy in the longer term.The mere suggestion of this may be enough to get Whitehall departments collaborating more effectively to fill "the hole at the centre."
A METHOD FOR COUPLING PROTEIN ANTIGENS TO ERYTHROCYTES
Authors: Leon R. Cole, Virginia R. Farrell
Journal: The Journal of Experimental Medicine (1955)

A technique has been described whereby tuberculin PPD is coupled, via tetrazotized benzidne, onto the surfaces of formalinized red blood cells. A stable antigen preparation is thereby obtained, which may be stored at -40 degrees C. The purpose of the present method is to facilitate the study of antibody to tuberculoprotein.
Matrix metalloproteinases modulate ameboid-like migration of neutrophils through inflamed interstitial tissue
Authors: Max Lerchenberger, Bernd Uhl, Konstantin Stark, Gabriele Zuchtriegel, Annekathrin Eckart, Meike Miller, Daniel Puhr-Westerheide, Marc Praetner, Markus Rehberg, Alexander G. Khandoga, Kirsten Lauber, Steffen Massberg, Fritz Krombach, Christoph A. Reichel
Journal: Blood (2013)
Lowering plasma free fatty acids with Acipimox mimics the antidiabetic effects of the [beta ]3-adrenergic agonist CL-316243 in obese Zucker diabetic fatty rats
Authors: Jean-Christophe Blach[egrave]re, Fleurette P[eacute]russe, Ludwik J. Bukowiecki
Journal: Metabolism (2001)
Computed tomography findings in invasive pulmonary aspergillosis in non-neutropenic transplant recipients and neutropenic patients, and their prognostic value
Authors: Seong Yeon Park, Chaehun Lim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Jae-Woo Song, Mi Young Kim, Eun Jin Chae, Kyung-Hyun Do, Koun-Sik Song, Joon Beom Seo, Sung-Han Kim
Journal: Journal of Infection (2011)