tbuckley/cabot-search huggingface dataset:
P4-01-10: The Role of the Steroid Receptor Coactivator SRC1 and Its Functional Partner HOXC11 in the Development of Endocrine Resistant Breast Cancer.
Authors: CA Walsh, D McCartan, ADK Hill, LS Young
Journal: Cancer Research (2011)

Abstract Background: The steroid receptor coactivator; SRC1, has been well described in the development of endocrine resistant breast cancer. SRC1 associates with clinically aggressive tumours and promotion of distant metastasis. It directly interacts with the developmental transcription factor, HOXC11 and together they are found to strongly predict poor disease-free survival in breast cancer patients (hazard ratios: 5.79; P &amp;lt; 0.0001). In this study, we investigate the mechanism of SRC1 and HOXC11 action in tumour adaptability and subsequent resistance to endocrine therapy. Materials and Methods: Cells which are resistant to tamoxifen (LY2s) have enhanced SRC1 and HOXC11 mRNA and protein expression in comparison to their endocrine sensitive parent cells (MCF-7s). ChIP-sequencing data for SRC1- and HOXC11- DNA interactions in conjunction with DNA microarray and RNA-sequencing data identified potential signalling targets at play in the LY2 model of endocrine resistance. Real-time analysis and flow cytometry confirmed these interactions at a transcriptional and protein level. These observations were further confirmed in primary breast cancer cultures using flow cytometry. Results: SRC1 and HOXC11 interactions are driven in tamoxifen treated LY2 resistant cells. Combined SRC1 ChIP-sequencing and expression array data analysed in conjunction with HOXC11 ChIP-sequencing and RNA-sequencing data reveal that the SRC1/HOXC11 transcriptional process can orchestrate the loss of luminal cell markers such as ERα, CD24 and PTCH1 whilst concomitantly upregulating mediators of tumourigenicity such as CD44 and MSI2. Primary breast cancer cultures confirm the loss of CD24 in tamoxifen resistant patients. In these patients, loss of CD24 was accompanied by loss of steroid receptor expression (ERα and PR) and by a gain of the basal marker CD44. Discussion: Here, we describe a new signalling pathway where SRC1 and HOXC11 regulate two distinct but complementary mechanisms to drive tumour adaptability. Silencing of luminal cell markers and a concomitant increase in a basal cell phenotype has the potential to alter the survival mechanism of breast cancer cells to evade targeted therapy. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P4-01-10.
Long-Term Follow-Up of Serum N-Terminal Propeptide of Collagen Type III Levels in Patients with Chronic Liver Disease
Authors: Kurt Weigand, Pierre-Yves Zaugg, Alain Frei, Arthur Zimmermann
Journal: Hepatology (1984)

To evaluate the diagnostic and prognostic significance of the N -terminal propeptide of collagen Type III (Col 1-3) in chronic liver disease, the peptide level was measured in the serum of 4 patients with primary biliary cirrhosis, 5 with chronic persistent hepatitis, 12 with chronic active hepatitis, and 1 with autoimmune hepatitis, for a period of 2 to 10 years and compared with liver function and histology. In primary biliary cirrhosis, Col 1-3 peptide levels were always elevated, regardless of medical therapy; however, after liver transplantation in one patient, the Col 1-3 peptide level decreased. In chronic persistent hepatitis, the peptide level fluctuated around the upper limit of normal. Among patients with chronic active hepatitis, the Col 1-3 peptide level normalized in 2 patients during remission, but was elevated in 7 patients who developed cirrhosis. Only in a patient with autoimmune hepatitis was the Col 1-3 peptide level normal, although the patient developed cirrhosis during prednisone therapy. When prednisone was withdrawn, the Col 1-3 peptide level increased. The data suggest that the serum Col 1-3 peptide may estimate the course of liver fibrosis in chronic liver disease and has prognostic value, particularly in chronic active hepatitis. Persistent elevation suggests ongoing fibrosis and development of cirrhosis; normalization suggests remission.
Medical Students, Truth, and Autopsies
Authors: George D. Lundberg
Journal: JAMA (1983)

One of the nicest things about our American Medical Association in recent years has been the proliferation of medical student members and the emergence of the Medical Student Section as a real political force. Students are wonderful creatures; they are magnificent at perceiving problems and conceiving solutions. They may not be as good at effecting solutions but that does not mean we should not consider their suggestions. At the June 1983 Annual Meeting of the AMA, the Medical Student Section sponsored Resolution 137, which, after appropriate deliberation by Reference Committee E, was approved by the House of Delegates, thus becoming official AMA policy. The resolution reads as follows: Resolved, That the American Medical Association develop and distribute to students and residents appropriate material stressing the importance and necessity of the autopsy as a service both to the medical community and to society as a whole; and be it further Resolved,
Production and Characterization of Human Glioma Cell-Derived Monocyte Chemotactic Factor
Authors: J.-i. Kuratsu, E. J. Leonard, T. Yoshimura
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Production and Characterization of Human Glioma Cell-Derived Monocyte Chemotactic Factor Get access Jun-ichi Kuratsu, Jun-ichi Kuratsu Search for other works by this author on: Oxford Academic PubMed Google Scholar Edward J. Leonard, Edward J. Leonard Search for other works by this author on: Oxford Academic PubMed Google Scholar Teizo Yoshimura Teizo Yoshimura * *Correspondence to: Dr. Teizo Yoshimura, Immunopathology Section, Laboratory of Immunobiology, National Cancer Institute, Frederick, MD 21701. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 5, 1 March 1989, Pages 347–351, https://doi.org/10.1093/jnci/81.5.347 Published: 01 March 1989 Article history Received: 23 September 1988 Revision received: 01 December 1988 Accepted: 03 December 1988 Published: 01 March 1989
1059. Development of a Novel Regulatory System Allowing Doxycycline-Controlled Suppression of Target Genes in Mammalian Cells
Authors: Lahouari Amar, Jacques Mallet, Roland Vogel
Journal: Molecular Therapy (2005)

Top of pageAbstract
The efficient and specific suppression of target genes by RNA interference (RNAi) is a remarkable new approach that may find applications in human therapy whenever genes involved in the respective pathology have to be inhibited. Clinical applications will require a regulatory system that allows control of RNAi by administration of a small inducer molecule. The treatment could then be adapted to the needs of the patient and, should complications arise, the therapy could be stopped or interrupted. RNAi based gene suppression can be induced in target cells by short hairpin RNAs (shRNAs) that are expressed under the control of RNA polymerase III promoters in order to avoid disturbing poly A sequences. To control RNAi by inducible and reversible expression of shRNAs, we developed a novel regulatory system. This system is based on a novel tetracycline-dependent transactivator capable of inducing transcription of shRNAs from a minimal RNA polymerase III promoter in the presence of doxycycline. As a proof-of-principle, tetracycline-controlled RNA interference was used to regulate the expression of GFP in HEK 293T cells stably expressing this transgene. RNA interference was induced by administration of doxycycline yielding a 90% reduction of GFP expression. The effect of doxycycline on the expression of GFP was dose- and time-dependent. In particular, the down-regulation of GFP was reversible after withdrawal of doxycycline, as observed by reappearance of GFP fluorescence.
PSYCHOLOGICAL RISK FACTORS FOR OVERUSE INJURIES IN ELITE ATHLETICS: A COHORT STUDY IN SWEDISH YOUTH AND ADULT ATHLETES
Authors: T Timpka, J Jacobsson, Ö Dahlström, J Kowalski, V Bargoria, J Ekberg, S Nilsson, P Renström
Journal: British Journal of Sports Medicine (2014)

Background There is growing evidence that athletes' psychological characteristics are of importance for understanding overuse injuries in sports. Objective To examine the importance of psychological factors as risk indicators for sustaining athletics injuries. Design Cohort study with 52 weeks duration. Setting Swedish male and female youth and adult elite athletics athletes. Participants Athletes ranked in the national top 10 in each event were invited to a one-year surveillance study. Among those consenting to participate (n=292), 73% (n=212) completed a psychological survey at baseline. Risk factor assessment Event group, previous injury, training volume and intensity (measured by the TLRI), perceived motivational climate (PMCSQ), coping behaviors (Brief Cope), body consciousness and hyperactivity (BCS-ADHD), commitment to exercise (CES), and interactions with gender and age. Main outcome measurements Time to first injury causing full or partial time loss from athletics. Results 199 (68%) athletes reported an injury during the study period. Ninety-six percent of reported injuries were classified as associated with overuse. Cox proportional hazards regression analyses showed that maladaptive coping through self-blame (P=.001; HR 1.37 (95% CI 1.14–1.67)) and hyperactivity (P=.025; HR=1.01 (95% 1.00–1.02)) were associated with increased injury risk. Additionally, male adult athletes with a previous serious injury had an increased risk of injury (P=.043; HR=2.05 (95% CI 1.02–4.07)), while the injury risk was decreased for male(P=.032; HR=0.47 (95% CI 0.23–0.94)) and female (P=.025; HR=0.49 (95% CI 0.26–0.91)) adult athletes without previous injury. Conclusions The psychological factors self-blame and hyperactivity earlier linked to non-suicidal self-injury in general populations were together with causal interactions combining previous injury, age and gender found to be related with overuse injury in athletics athletes. Further studies on associations between injury and indicators of depression and stress in elite athletics athletes are warranted.
Primary Central Nervous System Lymphomas: A Validation Study of Array-Based Comparative Genomic Hybridization in Formalin-Fixed Paraffin-Embedded Tumor Specimens
Authors: Esteban Braggio, Ellen Remstein McPhail, William Macon, M. Beatriz Lopes, David Schiff, Mark Law, Stephanie Fink, Debra Sprau, Caterina Giannini, Ahmet Dogan, Rafael Fonseca, Brian Patrick O'Neill
Journal: Clinical Cancer Research (2011)

Abstract Purpose: Only a limited number of genetic studies have been conducted in primary central nervous system lymphomas (PCNSL), partly due to the rarity of the tumors and the very limited amount of available tissue. In this report, we present the first molecular characterization of copy number abnormalities (CNA) of newly diagnosed PCNSL by array-based comparative genomic hybridization (aCGH) in formalin-fixed paraffin-embedded (FFPE) specimens and compare the results with matched, frozen tumor specimens. Experimental Design: We conducted aCGH in FFPE tissues from PCNSL. Results were compared with matched, paired, frozen tumors. Results: Our analysis confirmed the good to fair quality and reliability of the data generated from limited amounts of tumoral FFPE tissue. Overall, all PCNSL cases were characterized by highly complex karyotypes, with a median of 23 CNAs per patient (range, 17–47). Overall, 20 chromosomal regions were recurrently found in more than 40% of cases. Deletions of 6p21, 6q, and 9p21.3 and gain of 12q12-q24.33 were the commonest CNAs. Other minimal affected regions were defined, and novel recurrent CNAs affecting single genes were identified in 3q26.32 (TBL1XR1) and 8q12.1 (TOX). Conclusions: The results obtained are encouraging. Larger archival tissue collections can now be analyzed to complement the still fragmented knowledge we have of the genetic basis of the PCNSL. Clin Cancer Res; 17(13); 4245–53. ©2011 AACR.
Can we change our vantage point to explore imaginal neglect?
Authors: Paolo Bartolomeo, Sylvie Chokron
Journal: Behavioral and Brain Sciences (2002)

Right brain-damaged patients with unilateral neglect, who ignore left-sided visual events, may also omit left-sided details when describing known places from memory. Modulating the orienting of visual attention may ameliorate imaginal neglect. A first step toward explaining these phenomena might be to postulate that space-related imagery is a cognitive activity involving attentional and intentional aspects.
Body Mass Index and Liver Stiffness Affect Accuracy of Ultrasonography in Detecting Steatosis in Patients With Chronic Hepatitis C Virus Genotype 1 Infection
Authors: Fabio Salvatore Macaluso, Marcello Maida, Calogero Cammà, Daniela Cabibi, Nicola Alessi, Giuseppe Cabibbo, Vito Di Marco, Antonio Craxì, Salvatore Petta
Journal: Clinical Gastroenterology and Hepatology (2013)
The Treatment of Fractures with Notes upon a Few Common Dislocations.
Authors: Charles Locke Scudder
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leukemia in the Nevada 'Smoky' Bomb Test
Authors: V. P. Bond
Journal: JAMA (1980)

In this issue ofThe Journal, Caldwell and colleagues (p 1575) report a possible increase in leukemia among participants in military maneuvers at a nuclear bomb test site. We congratulate the authors on their thoroughness. One interpretation of the excess of leukemia suggests a greater effect per rem at low-dose levels. The present situation is remarkably similar to that surrounding the association between fallout from Nevada weapons tests and a reported increased leukemia incidence in Utah, also published with an accompanying editorial.<sup>1,2</sup>In the present article and the previous one,<sup>1</sup>more remarkable than the reported positive association is the extent to which the authors discuss difficulties in reaching conclusions from their data. Additional reasons for their reluctance to draw conclusions can be adduced. Since large-scale studies of this nature are usually carried out with the expectation of demonstrating something not previously known, one asks why the study? What
Kinetics and Cellular Site of Glycolipid Loading Control the Outcome of Natural Killer T Cell Activation
Authors: Jin S. Im, Pooja Arora, Gabriel Bricard, Alberto Molano, Manjunatha M. Venkataswamy, Ian Baine, Elliot S. Jerud, Michael F. Goldberg, Andres Baena, Karl O.A. Yu, Rachel M. Ndonye, Amy R. Howell, Weiming Yuan, Peter Cresswell, Young-tae Chang, Petr A. Illarionov, Gurdyal S. Besra, Steven A. Porcelli
Journal: Immunity (2009)

CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell- and Th2 cell-type cytokines. We analyzed presentation of NKT cell activating alpha galactosylceramide (alphaGalCer) analogs that give predominantly Th2 cell-type cytokine responses to determine how ligand structure controls the outcome of NKT cell activation. Using a monoclonal antibody specific for alphaGalCer-CD1d complexes to visualize and quantitate glycolipid presentation, we found that Th2 cell-type cytokine-biasing ligands were characterized by rapid and direct loading of cell-surface CD1d proteins. Complexes formed by association of these Th2 cell-type cytokine-biasing alphaGalCer analogs with CD1d showed a distinctive exclusion from ganglioside-enriched, detergent-resistant plasma membrane microdomains of antigen-presenting cells. These findings help to explain how subtle alterations in glycolipid ligand structure can control the balance of proinflammatory and anti-inflammatory activities of NKT cells.
Risk of Tuberculosis and Time Spent in Jail-Reply
Authors: Eran Bellin
Journal: JAMA (1993)

In Reply.  —Dr DiFerdinando identifies methodologic issues that do not invalidate the association between incarceration and TB.   Incomplete ascertainment of TB cases constitutes a misclassification of diseased patients as healthy. Nondifferential misclassifications bias epidemiologic studies to the null hypothesis, which means that the true association is stronger than that observed.  The use of  in  to measure the association of time in jail with TB is perfectly valid. The measure encompasses all the time a subject was remanded to the department of corrections, including central booking, holding pens, and receiving rooms. It is not merely time spent on Rikers Island. While it would be useful to have a detailed breakdown of this experience, this was beyond the scope of our study. Conceivably, specific aspects of incarceration carry an even higher risk of developing TB than we found when looking at incarceration in the aggregate.  The concern that the time
LP-BM5 virus–infected mice produce activating autoantibodies to the AMPA receptor
Authors: Elena Koustova, Yoshitatsu Sei, Linda Fossom, Mei-Ling Wei, Peter N.R. Usherwood, N. Bradley Keele, Michael A. Rogawski, Anthony S. Basile
Journal: Journal of Clinical Investigation (2001)

Autoantibodies to alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors may contribute to chronic hyperexcitability syndromes and neurodegeneration, but their origin is unclear. We examined LP-BM5 murine leukemia virus-infected mice, which manifest excitotoxic brain lesions and hypergammaglobulinemia, for the presence of AMPA-receptor Ab's. Endogenous IgG accumulated upon neurons in the neocortex and caudate/putamen of infected mice and interacted with native and recombinant AMPA-receptor subunits with the following relative abundance: GluR3 > or = GluR1 > GluR2 = GluR4, as determined by immunoprecipitation. In a radioligand assay, IgG preparations from infected mice specifically inhibited [(3)H]AMPA binding to receptors in brain homogenates, an activity that was lost after preadsorbing the IgG preparation to immobilized LP-BM5 virus. These IgGs also evoked currents when applied to hippocampal pyramidal neurons or to damaged cerebellar granule neurons. These currents could be blocked using any of several AMPA receptor antagonists. Thus, anti-AMPA-receptor Ab's can be produced as the result of a virus infection, in part through molecular mimicry. These Ab's may alter neuronal signaling and contribute to the neurodegeneration observed in these mice, actions that may be curtailed by the use of AMPA-receptor antagonists.
How To Be a Clinician in a Socialist Country
Authors: GUNNAR BIÖRCK
Journal: Annals of Internal Medicine (1977)

Some of the events that have contributed to the development of the present Swedish health care system are reviewed. Although there are several useful elements in system--and these are the ones usually presented by official channels--the impact on the freedom of the medical profession and on the patient-physician relationship is considerable and destructive to the concepts of a free profession. It is necessary to take such effects into account in the planning for nationalized health services anywhere in the world.
NT‐proBNP response to dobutamine stress echocardiography predicts left ventricular contractile reserve in dilated cardiomyopathy
Authors: Frangiskos I. Parthenakis, Alexandros P. Patrianakos, Costas N. Haritakis, Evangelos A. Zacharis, Eva G. Nyktari, Panos E. Vardas
Journal: European Journal of Heart Failure (2008)
Treatment-Resistant Depression
Authors: Jambur Ananth
Journal: Psychotherapy and Psychosomatics (1998)

Our ability to treat depression has improved with the availability of receptor-specific and chemically diverse groups of antidepressants. Even now, most of the short-term studies indicate that about 20% of depressed patients remain resistant to treatment. Therefore, it is important to properly assess the treatment-resistant depressed (TRD) patients and to separate the truly refractory patients from those inadequately treated. Undiagnosed medical conditions should be eliminated. TRD is neither a clinically nor a biologically identifiable entity. As there are no established methods for the treatment of TRD, all options should be considered. The clinician can be enriched by the knowledge of the treatment modalities available, and yet, in treating an individual patient, clinical skills, intuitive judgment, family history of response to drugs and side effects, all play a vital role. Several of the approaches described in the paper indicate available methods and their merits in general but there is no way of ascertaining by which particular method a patient should be treated. The three common methods of treatment are substitution of one antidepressant drug for another, combination therapies and augmentation techniques. These are based on clinical experiences and not research findings. Therefore the treatment of TRD patients is more an art than a science. The physician should assess all the psychopathological, phenomenological and psychosocial variables to appropriately treat an individual patient.
Specific epicutaneous immunotherapy prevents sensitization to new allergens in a murine model
Authors: Lucie Mondoulet, Vincent Dioszeghy, Emilie Puteaux, Mélanie Ligouis, Véronique Dhelft, Camille Plaquet, Christophe Dupont, Pierre-Henri Benhamou
Journal: Journal of Allergy and Clinical Immunology (2015)
Potential Role of the Inactivated X Chromosome in Ovarian Epithelial Tumor Development
Authors: P. C. Cheng, J. A. Gosewehr, T. M. Kim, M. Velicescu, M. Wan, J. Zheng, J. C. Felix, K. F. Cofer, P. Luo, B. H. Biela, G. Godorov, L. Dubeau
Journal: JNCI Journal of the National Cancer Institute (1996)

Background:Ovarian epithelial tumors can be divided into subcategories often regarded as different stages of neoplastic transformation. Cystadenomas belong to the least aggressive subgroup and are noninvasive and nonmetastatic. Ovarian tumors of low malignant potential (LMP) are intermediate between cystadenomas and carcinomas and show markedly reduced invasive and metastatic abilities. Invasion and metastasis are the hallmarks of carcinomas, which constitute the most aggressive subgroup and can be further subdivided into different grades.
An evolutionary model for the learning of language
Authors: Jechil S. Sieratzki, Bencie Woll
Journal: Behavioral and Brain Sciences (1998)

This commentary deals with the relation between human language and nonverbal signals used by nonhuman primates. It suggests that human language could have developed through the interaction of procedural learning with a preexisting system for socio-affective communication. The introduction of “content” into existing “frames” requires a neurobiologically plausible learning mechanism.