Insensitivity of Platelet Adenylate Cyclase to Prostaglandin E_1 in Patients with Hypokalemic Diseases
Authors: HANS-GEORG GÜLLNER
Journal: Annals of Internal Medicine (1984)

Brief Reports1 September 1984Insensitivity of Platelet Adenylate Cyclase to Prostaglandin E1 in Patients with Hypokalemic DiseasesHANS-GEORG GÜLLNER, M.D., MARIAN S. KAFKA, Ph.D., JOHN R. GILL Jr., M.D.HANS-GEORG GÜLLNER, M.D.Search for more papers by this author, MARIAN S. KAFKA, Ph.D.Search for more papers by this author, JOHN R. GILL Jr., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-3-342 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHypokalemia is associated with resistance to the physiologic effects of vasopressin, parathyroid hormone, and norepinephrine (1-4). The physiologic actions of each of these hormones are mediated by cyclic adenosine monophosphate (AMP). To determine whether this resistance is caused by impaired generation of cyclic AMP by the target tissues, the regulation of adenylate cyclase was studied in blood platelets, an easily accessible tissue. Cyclic AMP production was measured in platelet preparations from two groups of female patients, those with Bartter's syndrome and those with other disorders involving hypokalemia, such as psychogenic vomiting and the syndrome of hypokalemia with renal tubulopathy ("familial...References1. BECKWEBSTER NS. Impaired urinary concentrating ability and cyclic AMP in K + -depleted rat kidney. Am J Physiol. 1976;231:1204-8. CrossrefMedlineGoogle Scholar2. MARCUSAURBACH RJ. Bioassay of parathyroid hormone in vitro with a stable preparation of adenyl cyclase from rat kidney. Endocrinology. 1969;85:801-10. CrossrefMedlineGoogle Scholar3. BECKDAVIS NB. Impaired renal response to parathyroid hormone in potassium depletion. Am J Physiol. 1975;228:179-83. CrossrefMedlineGoogle Scholar4. GÜLLNERGILLBARTTERLAKELAKATUA HJFCD. Correction of increased sympathoadrenal activity in Bartter's syndrome by inhibition of prostaglandin synthesis. J Clin Endocrinol Metab. 1980;50:857-61. CrossrefMedlineGoogle Scholar5. GÜLLNERGILLBARTTERCHANDICKMAN HJFJP. A familial disorder with hypokalemic alkalosis, hyperreninemia, aldosteronism, high urinary prostaglandins and normal blood pressure that is not "Bartter's syndrome. " Trans Assoc Am Physicians. 1979;92:175-88. MedlineGoogle Scholar6. KAFKATALLMANSMITHCOSTA MJCJ. Alpha-adrenergic receptors on human platelets. Life Sci. 1977;21:1429-38. CrossrefMedlineGoogle Scholar7. GALVEZBAYROBERTSFERRIS OWBT. The hemodynamic effects of potassium deficiency in the dog. Circ Res. 1977;40(suppl 1):I11-6. MedlineGoogle Scholar8. GÜLLNERGRAFGILLMITCHELL HAJM. Hypokalemia stimulates prostacyclin synthesis in the rat. Clin Sci. 1983;65:43-6. CrossrefMedlineGoogle Scholar9. GÜLLNERCERLETTIBARTTERSMITHGILL HCFJJ. Prostacyclin overproduction in Bartter's syndrome. Lancet. 1979;2:767-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: National Institutes of Health Bethesda, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBartter’s Syndrome 1 September 1984Volume 101, Issue 3Page: 342-343KeywordsAdenosine monophosphateBloodCyclic adenosine monophosphateHormonesNorepinephrineParathyroid hormonePlateletsProstaglandinVasopressinVomiting ePublished: 1 December 2008 Issue Published: 1 September 1984 PDF downloadLoading ...