tbuckley/cabot-search huggingface dataset:
DOCK8 is critical for the survival and function of NKT cells
Authors: Greg Crawford, Anselm Enders, Uzi Gileadi, Sanda Stankovic, Qian Zhang, Teresa Lambe, Tanya L. Crockford, Helen E. Lockstone, Alexandra Freeman, Peter D. Arkwright, Joanne M. Smart, Cindy S. Ma, Stuart G. Tangye, Christopher C. Goodnow, Vincenzo Cerundolo, Dale I. Godfrey, Helen C. Su, Katrina L. Randall, Richard J. Cornall
Journal: Blood (2013)
Immunological mechanisms of the antitumor effects of supplemental oxygenation
Authors: Stephen M. Hatfield, Jorgen Kjaergaard, Dmitriy Lukashev, Taylor H. Schreiber, Bryan Belikoff, Robert Abbott, Shalini Sethumadhavan, Phaethon Philbrook, Kami Ko, Ryan Cannici, Molly Thayer, Scott Rodig, Jeffrey L. Kutok, Edwin K. Jackson, Barry Karger, Eckhard R. Podack, Akio Ohta, Michail V. Sitkovsky
Journal: Science Translational Medicine (2015)

Respiratory hyperoxia stimulates lung tumor regression by promoting T cell infiltration into the tumors and decreasing immunosuppression.
The Intestinal Excretion of Digitoxin in the Rat
Authors: SHIRLEY ST. GEORGE, MEYER FRIEDMAN
Journal: Circulation (1952)

Rats given a parenteral injection of digitoxin (1 µg. per gram of body weight) were found to excrete approximately 15 to 18 per cent of the dose in their feces. This fecal digitoxin however came from the bile, and there was no evidence of any active secretion of the glycoside by the bowel wall itself.
Poly(l-lysine) nanostructured particles for gene delivery and hormone stimulation
Authors: Xin Zhang, Mustapha Oulad-Abdelghani, Alexander N. Zelkin, Yajun Wang, Youssef Haîkel, Didier Mainard, Jean-Claude Voegel, Frank Caruso, Nadia Benkirane-Jessel
Journal: Biomaterials (2009)
Ticarcillin and Assay of Tobramycin
Authors: CHRISTINA DALMADY-ISRAEL
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 March 1984Ticarcillin and Assay of TobramycinCHRISTINA DALMADY-ISRAEL, PHARM.D., PAUL J. GREEN, PH.D., GARY E. SLOSKEY, PHARM.D., PETER H. VLASSES, PHARM.D.CHRISTINA DALMADY-ISRAEL, PHARM.D.Search for more papers by this author, PAUL J. GREEN, PH.D.Search for more papers by this author, GARY E. SLOSKEY, PHARM.D.Search for more papers by this author, PETER H. VLASSES, PHARM.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-3-460_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the report of Graves and coworkers (1) about discrepancies among serum digoxin concentrations obtained by several different immunoassays in patients with renal impairment. We have recently seen assay-dependent differences between tobramycin serum concentrations in patients with renal failure who are receiving ticarcillin.In nine serum samples from four patients (estimated creatinine clearances, 25 to 75 mL/min) receiving tobramycin and ticarcillin (8 to 18 g/d), we noted that the serum concentrations of tobramycin [see the Editor's note below] obtained by system A, a homogenous enzyme immunoassay (EMIT; Syva Company, Palo Alto, California), were consistently...References1. GRAVESBROWNVALDES SBR. An endogenous digoxin-like substance in patients with renal impairment. Ann Intern Med. 1983;99:604-8. LinkGoogle Scholar2. PICKERINGGEARHART LP. Effect of time and concentration upon interaction between gentamicin, tobramycin, netilmicin or amikacin, and carbenicillin or ticarcillin. Antimicrob Agents Chemother. 1979;15:592-6. CrossrefMedlineGoogle Scholar3. CHOWQUINTILIANINIGHTINGALE MRC. In vivo inactivation of tobramycin by ticarcillin. JAMA. 1982;247:658-9. CrossrefMedlineGoogle Scholar4. EBERTCLEMENTI SW. In vitro inactivation of gentamicin by carbenicillin compared by EMIT® and microbiological assays [Abstract]. Drug Intell Clin Pharm. 1983;17:451. Google Scholar5. COCKCROFTGAULT DM. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16:31-41. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHRISTINA DALMADY-ISRAEL, PHARM.D.; PAUL J. GREEN, PH.D.; GARY E. SLOSKEY, PHARM.D.; PETER H. VLASSES, PHARM.D.Affiliations: Thomas Jefferson University Hospital and Jefferson Medical College Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1984Volume 100, Issue 3Page: 460-461KeywordsAttentionCreatinineEnzyme immunoassayEnzyme multiplied immunoassay techniqueImmunoassaysRenal failure ePublished: 1 December 2008 Issue Published: 1 March 1984 PDF downloadLoading ...
The protective effects of dexmedetomidine on the liver and remote organs against hepatic ischemia reperfusion injury in rats
Authors: Adnan Tüfek, Orhan Tokgöz, İbrahim Aliosmanoglu, Ulaş Alabalik, Osman Evliyaoglu, Taner Çiftçi, Abdülmenap Güzel, Zeynep Baysal Yıldırım
Journal: International Journal of Surgery (2012)
Pronounced Benefit of Coronary Stenting and Adjunctive Platelet Glycoprotein IIb/IIIa Inhibition in Complex Atherosclerotic Lesions
Authors: Fernando A. Cura, Deepak L. Bhatt, A. Michael Lincoff, Samir R. Kapadia, Philippe L. L’Allier, Khaled M. Ziada, Katherine E. Wolski, David J. Moliterno, Sorin J. Brener, Stephen G. Ellis, Eric J. Topol
Journal: Circulation (2000)

Previous trials testing stents compared with balloon angioplasty excluded patients with complex lesions and did not assess the effect of adjunctive platelet IIb/IIIa inhibition. This analysis sought to assess the effect of stenting and abciximab specifically for patients with complex lesions.Patients with complex lesions (long, tandem, severely calcified, restenotic, thrombotic, or ostial; total occlusions; bifurcations; saphenous vein grafts; and multivessel interventions) from the Evaluation of PTCA to Improve Long-Term Outcome by c7E3 GP IIb/IIIa Receptor Blockade (EPILOG) and the Evaluation of Platelet IIb/IIIa Inhibitor for Stenting (EPISTENT) trials were included in the analysis. The 1-year combined death or myocardial infarction rates in the 4 treatment groups were as follows: balloon angioplasty/placebo, 14.2%; stent/placebo, 15.8%; balloon angioplasty/abciximab, 7.6%; and stent/abciximab, 8.0% (P<0.001). Death rates were 3.2%, 3.1%, 2.1%, and 0.5%, respectively (P=0.03). The incidence of target vessel revascularization at 1 year was 30.5%, 18.0%, 24.4%, and 19.7% in the 4 groups, respectively (P<0.001). After adjustment for baseline differences, multivariate analysis demonstrated that the rate of death or myocardial infarction was independently reduced by balloon angioplasty/abciximab (hazard ratio, 0.51; P<0.001) and stent/abciximab (hazard ratio, 0.60; P=0.02) but was not affected by the use of stents alone. Conversely, target vessel revascularization was reduced by stent/placebo (hazard ratio, 0.53; P<0.001), stent/abciximab (hazard ratio, 0.58; P<0.001), and balloon angioplasty/abciximab (hazard ratio, 0.74; P=0.006) compared with balloon angioplasty/placebo, respectively.The combination of stenting and abciximab during percutaneous coronary interventions for patients with angiographically complex lesions confers additive long-term benefit with respect to death, myocardial infarction, and target vessel revascularization.
Termination of Reentry by Lidocaine in the Tricuspid Ring In Vitro
Authors: Hailing Fei, Dina Yazmajian, Michael S. Hanna, Lawrence H. Frame
Journal: Circulation Research (1997)

We hypothesized that drugs with rapid recovery kinetics from use-dependent sodium channel block could promote oscillatory termination of reentry by enhancing interval-dependent conduction. Mechanisms of termination were related to properties of the reentrant circuit. Nine adjustable reentrant preparations were used in which the canine atrial tricuspid ring was cut and then reconnected electronically by sensing activation on one side of the cut and pacing the other after an adjustable delay. The cycle length and diastolic interval during reentry were manipulated by changing this delay. Lidocaine (1.28×10 −5 mol/L) significantly increased refractoriness (94±39 ms) and the slope of the conduction curve (−0.12±0.07) at the site of block during pacing. Lidocaine terminated sustained reentry by two mechanisms. Early termination resulted from increased cycle length oscillation and refractoriness (reproducible in each experiment) but only at short delays with short initial diastolic intervals. The range of delays showing this mechanism of termination was 100±48 ms. Increased cycle-length oscillation resulted from an increased slope of the conduction curve. In eight experiments, lidocaine terminated reentry by causing fixed block after 50 minutes of drug superfusion, which prevented reentry at all delays. Fixed block occurred at one of two vulnerable sites and was transiently reversed by acetylcholine. Termination due to refractory block occurred only when the initial diastolic interval was short, and termination due to fixed block developed when there was a susceptible region with a low safety factor for propagation. Fast recovery from sodium channel block promotes oscillatory termination by increasing the slope of the conduction curve.
Low Plasma Adiponectin Levels Are Associated With Increased Hepatic Lipase Activity In Vivo
Authors: Jochen G. Schneider, Maximilian von Eynatten, Stephan Schiekofer, Peter P. Nawroth, Klaus A. Dugi
Journal: Diabetes Care (2006)

We thank Kobayashi et al. (1) for their interest in our work on the relationship between adiponectin and human plasma lipases (2, 3). These authors raise the question of whether differences in genetic background, BMI, or insulin levels of the studied populations could help to explain the differences with regard to statistical significance between their and our results.

Although we exclusively studied Caucasian subjects, other authors have recently reported an independent influence of adiponectin on …
Relation of Left Atrial Pathology to Atrial Fibrillation in Mitral Valvular Disease
Authors: GEORGE W. H. BAILEY
Journal: Annals of Internal Medicine (1968)

Biopsies of the posterior wall of the left atrium were obtained from 44 patients undergoing mitral surgery for mitral valvular disease, and the specimens were graded according to severity of morphologic change. In grade I the atrial myocardium is essentially normal; grade II patients show moderate to severe fibrosis and preservation of muscle mass and architecture; grade III patients show extensive fibrosis, a loss of muscle mass, and disruption of architecture. The pathological grading was compared with such clinical parameters as type of valvular lesion, rhythm before surgery, and degree of left atrial enlargement. Cardioversion was attempted after surgery whenever feasible. Nine patients were successfully cardioverted, and all had grade II changes. Three additional patients succeeded and then relapsed; one had grade II and two had grade III changes. In seven patients cardioversion failed, and six of these had grade III changes. The one exception was a patient in grade I who had a cardiomyopathy. We propose that fibrosis after rheumatic inflammatory insults leads to atrial fibrillation by disturbing impulse propagation in the atrium; prolonged atrial fibrillation leads to a disuse atrophy of muscle, and atrial fibrillation becomes irreversible. These pathologic changes may be used for predicting success or failure of cardioversion and probability of maintaining sinus rhythm.
Patients should have right to interact with their electronic records, report says
Authors: M. Limb
Journal: BMJ (2014)

Patents should be given a legal right to access their electronic health records, “interact with” them, and share them as they choose, a group of experts has recommended.

The NHS should compensate patients when data are lost or irresponsibly used, and trusts should lose their accreditation for training if they do not use electronic health records extensively, according to the Peter Sowerby Commission.1

“Failure to implement systems effectively is a regulatory issue,” it said.

The commission was set up by Imperial College London’s Institute of Global Health Innovation and led by its executive chairman, Thomas Hughes-Hallett.*

In a report …
Instantaneous blood flow responses to positive end-expiratory pressure with spontaneous ventilation.
Authors: R A Perschau, C J Pepine, W W Nichols, J B Downs
Journal: Circulation (1979)

Variable hemodynamic responses to positive end-expiratory pressure (PEEP) with spontaneous ventilation have been reported. To clarify these responses, 15 awake patients were studied using a catheter-tip velocity transducer to record phasic aortic root blood flow continuously before, during and after PEEP (10 cm H2O) applied with a face mask. Central blood volume and effective ventricular filling pressures were measured. Phasic pulmonary artery blood flow was also simultaneously recorded in three of these patients. PEEP produced an acute aortic blood flow reduction, detected within one respiratory cycle. Stroke volume decreased 12%, and since heart rate was unchanged, cardiac output also declined (p less than 0.05). Inspiratory-to-expiratory aortic flow changes were less during PEEP. In contrast, inspiratory-to-expiratory pulmonary artery flow alterations were exaggerated due to a marked flow decline during expiration. Central blood volume and effective left ventricular filling pressure decreased 9% and 19%, respectively (p less than 0.05 in all patients). The decrease in pulmonary artery flow was associated with a decrease in central blood volume in the three patients in whom pulmonary flow was measured. PEEP promptly reduces cardiac output during spontaneous ventilation, related to a decrease in pulmonary flow in expiration.
Abstract 4810: Persistent migration of cancer cells in a 3-D mechanically confined microenvironment
Authors: Daniel Irimia
Journal: Cancer Research (2010)

Abstract When cancer cells spread away from the primary tumour, they often follow the trajectories of lymphatic vessels, collagen fibres, white matter tracts, or other heterogeneous structures in tissues. To better understand this form of guided cell migration we designed a series of microfluidic devices that mechanically constrain migrating cancer cells inside microstructures with cross-section comparable to cell size and replicate critical 3D interactions that cancer cells would normally have inside tissues. We observed unexpectedly fast and persistent movement in one direction for several hours of cancer cells of different types. We observed the persistent motility in the absence of external gradients, suggesting the presence of intrinsic mechanisms driving cancer cell motility that are induced in conditions of mechanical confinement. To probe into the mechanisms responsible for this behaviour, we exposed cancer cells inside capillaries to drugs targeting the microtubules and measured significant reduction in the average migration speed in response. Surprisingly, a small numbers of cells appeared not to be affected by the treatment and displayed fast and persistent migration, comparable to untreated cells. The new matrix-free, 3D-confined motility assay is compatible with high-content, high-throughput analysis of cellular motility at single cell level and could provide useful insights into the biology of cancer cell migratory phenotype. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4810.
Prognostic significance of minimal residual disease in infants with acute lymphoblastic leukemia treated within the Interfant-99 protocol
Authors: V H J Van der Velden, L Corral, M G Valsecchi, M W J C Jansen, P De Lorenzo, G Cazzaniga, E R Panzer-Grümayer, M Schrappe, A Schrauder, C Meyer, R Marschalek, L L Nigro, M Metzler, G Basso, G Mann, M L Den Boer, A Biondi, R Pieters, J J M Van Dongen
Journal: Leukemia (2009)
First doctor suspended under GMC performance procedures
Authors: S. Kirwin
Journal: BMJ (1999)

The General Medical Council has suspended a doctor from practice for poor professional performance, under regulations being used for the first time.The GMC has previously only disciplined doctors for professional misconduct.

Dr Arefaine Haile, a GP registrar in Yorkshire, was suspended in December for a year “for the protection of members of the public” after his case was heard by the GMC's committee on professional performance (CPP).

The council had not received any complaints from the public, but Dr Haile's trainers at the practice were worried about his performance. They …
Report on the Cholera Epidemic of 1885 in Nepal; with a Short Description of the Topography and Inhabitants of the Valley
Authors: G. H. Gimlette
Journal: BMJ (1886)

NEPALProper, the most important, but by far the smallest, district the country, consists of a densely populated central valley, together smaller surrounding ones-Banepa, Duna Baisia, Kulpu Baisia, Nyak6t, Chitlong-usually considered with it, and to which, also, Europeans are admitted.The outline of the central valley is irregularly oval.The long dia- meter running from N. W. to S. E. is about sixteen miles in length, and the shorter from twelve to fifteen miles; the inhabited area, including parts of the sides of the adjacent mountains, may be esti- mated 800 s(luare miles.Its elevation is 4,700 feet above sea-level.cirle of hills surrounds it on all sides; their elevation varies from 4,600 feet above the valley, and from 5,200 to 9,300 above the sea.These hills shut in the valley so closely on every side, that only one narrow outlet remains iII the S. E. corner, through which the Baglunati escapes in its course towards the plins ; this river carries off the whole of the drainage of the valley, and the hills encircling it; it .flowsthrouigh the valley from N. to S. E., receives tributaries in its course, and is joined by the (Gishnumati at Kathmandu; the united streams form a broad river, which is partly dry during the hot weather, but swollen to a torrent in the rains.The surface of the valley is divided into portions of two different levels, the higher called Sars, and the lower, through which the rivers flow, Baisiyas; there is often a considerable difference in the level of adjacent Sars and Baisiyas, as much as 80 to 100 feet.It is most denely populated, besides containing three cities, each formerly the capital of a separate kingdom; there are many towns or large villages, and a great number of smaller villages and hamlets; in additioni, the open country is studded with isolated dwellings.population is estimated by the Nepalese at half a mnillion, and is probably not far short of 400,000; estimating the area, as I have done, at 300 square miles, this gives the almost incredible number of 1,333 inhabitants to the square mile.The climate of the valley is most temperate, much resembling that of the south of Europe, w-ith the exception of its far greater humiidity.year has been well divided, by one of my predecessors, into the following seasons: spring, from
THE MEDICAL TREATMENT OF PEPTIC ULCER.
Authors: FREDERICK C. SHATTUCK
Journal: JAMA (1901)

The personal experience of any malady is apt to enhance the interest of a physician therein, and should not detract from his knowledge thereof. Thus I have been led to analyze my hospital and private records of cases of peptic ulcer, which, for perhaps fifteen years, I have treated more rigidly than do most physicians.  For diagnostic purposes, cases of peptic ulcer may be divided into three classes: 1. Those which are entirely latent and present either no symptoms at any time or first manifest themselves by hemorrhage or perforation. 2. Those with symptoms of indigestion not easily distinguishable from those of indigestion arising from other cause. 3. Those with diagnostic symptoms. The first class is not of therapeutic importance unless hemorrhage or perforation occurs, throwing them into Class 3. Careful study of the case in all its aspects may in like manner transfer a case from the second to
REPORT OF THE MEDICAL DEPARTMENT OF THE UNIVERSAL EXPOSITION, ST. LOUIS, 1904.
Authors: LEONIDAS H. LAIDLEY
Journal: JAMA (1905)

<h3>ROSTER OF MEMBERS OF MEDICAL STAFF.</h3><h3>Medical Director:</h3> Dr. Leonidas H. Laidley, Jan. 15, 1902, to Jan. 1, 1905. <h3>Attending Surgeons:</h3> Dr. Josiah G. Moore, surgeon In charge, Emergency Hospital, July 1, 1902, to Dec. 12, 1904; Dr. M. E. Sheets, April 15, 1903, continued in service; Dr. Otto A. Wall, March 31, 1904, to Dec. 1, 1904; Dr. Clyn Smith, April 29, 1904, to Dec. 1, 1904; Dr. W. S. Lawrence, Jan. 4, 1904, to Feb. 3, 1904. <h3>Visiting Physician:</h3> Dr. Luther P. Walbridge, Nov. 15, 1902, to Dec. 15, 1904. <h3>Bacteriologist:</h3> Dr. Carl Fisch, July 20, 1904, to Dec. 1, 1904. <h3>Sanitary Officer:</h3> Dr. James M. Gassaway, lieutenant-colonel, Marine Hospital Service. June 14, 1904, to Dec. 1, 1904. <h3>Ambulance Surgeons:</h3> Dr. George E. Adams, Aug. 12, 1904, to Sept. 30, 1904; Dr. Ned O. Lewis, March 27, 1904, to Aug. 12, 1904; Dr. Henry M. DeMenil, April 30, 1904, to Nov. 15, 1904.
17β-Estradiol Attenuates Hypoxic Pulmonary Hypertension via Estrogen Receptor–mediated Effects
Authors: Tim Lahm, Marjorie Albrecht, Amanda J. Fisher, Mona Selej, Neel G. Patel, Jordan A. Brown, Matthew J. Justice, M. Beth Brown, Mary Van Demark, Kevin M. Trulock, Dino Dieudonne, Jagadeshwar G. Reddy, Robert G. Presson, Irina Petrache
Journal: American Journal of Respiratory and Critical Care Medicine (2012)

Rationale: 17β-Estradiol (E2) attenuates hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension (HPH) through an unknown mechanism that may involve estrogen receptors (ER) or E2 conversion to catecholestradiols and methoxyestradiols with previously unrecognized effects on cardiopulmonary vascular remodeling.Objectives: To determine the mechanism by which E2 exerts protective effects in HPH.Methods: Male rats were exposed to hypobaric hypoxia while treated with E2 (75 μg/kg/d) or vehicle. Subgroups were cotreated with pharmacologic ER-antagonist or with inhibitors of E2-metabolite conversion. Complementary studies were performed in rats cotreated with selective ERα- or ERβ-antagonist. Hemodynamic and pulmonary artery (PA) and right ventricular (RV) remodeling parameters, including cell proliferation, cell cycle, and autophagy, were measured in vivo and in cultured primary rat PA endothelial cells.Measurements and Main Results: E2 significantly attenuated HPH endpoints. Hypoxia increased ERβ but not ERα lung vascular expression. Co-treatment with nonselective ER inhibitor or ERα-specific antagonist rendered hypoxic animals resistant to the beneficial effects of E2 on cardiopulmonary hemodynamics, whereas ERα- and ERβ-specific antagonists opposed the remodeling effects of E2. In contrast, inhibition of E2-metabolite conversion did not abolish E2 protection. E2-treated hypoxic animals exhibited reduced ERK1/2 activation and increased expression of cell-cycle inhibitor p27Kip1 in lungs and RV, with up-regulation of lung autophagy. E2-induced signaling was recapitulated in hypoxic but not normoxic endothelial cells, and was associated with decreased vascular endothelial growth factor secretion and cell proliferation.Conclusions: E2 attenuates hemodynamic and remodeling parameters in HPH in an ER-dependent manner, through direct antiproliferative mechanisms on vascular cells, which may provide novel nonhormonal therapeutic targets for HPH.
Exposure Of Mice To Silica Crystals and Poly I:C Synergistically Enhances Neutrophil Infiltration and Epithelial Damage In The Airway
Authors: Hirotoshi Unno, Hideaki Morita, Hirohisa Saito, Kenji Matsumoto, Akio Matsuda
Journal: Journal of Allergy and Clinical Immunology (2014)
Emerin deficiency at the nuclear membrane in patients with Emery-Dreif uss muscular dystrophy
Authors: Atsushi Nagano, Ritsuko Koga, Megumu Ogawa, Yoshihiro Kurano, Junya Kawada, Ryozo Okada, Yukiko K. Hayashi, Toshifumi Tsukahara, Kiichi Arahata
Journal: Nature Genetics (1996)