Adult Coeliac Disease
Authors: ROBERT J. BOLT
Journal: Annals of Internal Medicine (1964)

Article1 April 1964Adult Coeliac DiseaseHistologic Results of Long-term Low Gluten DietROBERT J. BOLT, M.D., F.A.C.P., J. ANTHONY PARRISH, M.B., M.R.C.P., ARTHUR B. FRENCH, M.D., F.A.C.P., H. MARVIN POLLARD, M.D., F.A.C.P.ROBERT J. BOLT, M.D., F.A.C.P.Search for more papers by this author, J. ANTHONY PARRISH, M.B., M.R.C.P.Search for more papers by this author, ARTHUR B. FRENCH, M.D., F.A.C.P.Search for more papers by this author, H. MARVIN POLLARD, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-581 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHistologic changes in the mucosa of the duodenum and jejunum are consistently seen in patients with adult coeliac disease. Their presence lends strong support to the diagnosis of this disease. Conflicting evidence has been reported as to the degree of regression of the histologic lesion following successful treatment by removal of wheat, rye, oat, and barley gluten from the diet (1-5). The present report describes a series of patients carefully followed over several years with both serial small intestinal biopsies and serial absorption tests.MATERIALS AND METHODSThirteen patients with proved adult coeliac disease were followed from 1 to 5...References1. RUBIN CE: Some reflections on reversibility, gluten and the intestine. Gastroenterology 39: 260, 1960. MedlineGoogle Scholar2. YARDLEYBAYLESSNORTONHENDRIX JHTMJHTR: Celiac disease: a study of the jejunal epithelium before and after a gluten free diet. New Eng. J. Med. 267: 1173, 1962. CrossrefMedlineGoogle Scholar3. ASHWORTHCHEAR CTWC: Follow up of intestinal biopsy in nontropical sprue after gluten free diet and remission. Fed. Proc. 21: 880, 1962. MedlineGoogle Scholar4. BUCHANANGERRAND DJJW: Celiac disease: problems in diagnosis and effects of a gluten free diet. Ann. Intern. Med. 57: 85, 1962. LinkGoogle Scholar5. SHINER M: Follow-up studies in idiopathic steatorrhea Malabsorption. Syndrome Symposium, 2nd World Congress, Gastroenterology, Munich, Vol. 55, 1962 (S. Karger, Basel/New York, 1963). Google Scholar6. VAN DE KAMERTEN BAKKELWEIJERS JHHHHA: A rapid method for determination of fat in feces. J. Biol. Chem. 177: 347, 1949. CrossrefMedlineGoogle Scholar7. BOLTFRENCHPOLLARD RJABHM: A simplified multiple retrieving small bowel biopsy tube. Amer. J. Dig. Dis. 7: 773, 1962. CrossrefMedlineGoogle Scholar8. RUBINBRANDBORGPHELPSTAYLOR CELLPCHD: Studies of coeliac disease. I. The apparent identical and specific nature of the duodenal and proximal jejunal lesion in celiac disease and idiopathic sprue. Gastroenterology 38: 28, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, MichiganFrom the Department of Internal Medicine, Gastroenterology Section, University of Michigan Medical School and University Hospital, Ann Arbor, Michigan.This investigation was supported in part by research grant A-2554 and training grant 2A-5191 from the National Institute for Arthritis and Metabolic Disease, research grant C-3312 from the National Cancer Institute and facilities grant OG-18 from the Division of Research Facilities and Resources, National Institutes of Health, United States Public Health Service, Bethesda, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNon-endoscopic biopsy techniques: a reviewSlow and incomplete histological and functional recovery in adult gluten sensitive enteropathy.Das PeritoneumCellular infiltrate of jejunal biopsies in adult coeliac disease in relation to gluten withdrawalCase 48-1973A new technique for examining intestinal biopsiesThe effect on jejunal mucosa of withdrawing and adding dietary gluten in cases of idiopathic steatorrhoeaGenetics of Disorders of Intestinal Digestion and AbsorptionDiagnosis of coeliac disease in retrospect.Cytology of Intestinal Epithelial CellsSelective IgA deficiency with steatorrheaCoeliac DiseaseEffect of antibiotic therapy on gluten-sensitive enteropathyPeroral Biopsy of the Small Intestine 1 April 1964Volume 60, Issue 4Page: 581-586KeywordsHospital medicineJejunumLesionsMedical servicesMetabolic disordersMucous membranesPatientsPrevention, policy, and public healthResearch facilitiesResearch grants Issue Published: 1 April 1964 PDF DownloadLoading ...