A Controlled Study of Induced Diuresis in Barbiturate Intoxication
Authors: H. FRANKLIN BUNN
Journal: Annals of Internal Medicine (1965)

Article1 February 1965A Controlled Study of Induced Diuresis in Barbiturate IntoxicationH. FRANKLIN BUNN, M.D., GLENN D. LUBASH, M.D.H. FRANKLIN BUNN, M.D.Search for more papers by this author, GLENN D. LUBASH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-2-246 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptManagement of the patient comatose from barbiturates rests on maintenance of vital functions with meticulous attention to respiratory toilet (1). Other regimens employed to remove the toxic agent directly include hemodialysis, peritoneal dialysis, and attempts to increase urinary excretion of drug by liberal fluid administration, alkalinization, and osmotic agents (2-5). The value of these ancillary measures is supported for the most part by clinical impressions of shortened duration of coma and by reduced blood levels of drug. Induced diuresis has recently received much attention, but data demonstrating increased clearances of short and intermediate acting drugs have been scanty. In a...References1. PLUMSWANSON FAG: Barbiturate poisoning treated by physiologic methods. JAMA 163: 827, 1957. CrossrefMedlineGoogle Scholar2. SCHREINER GE: The role of hemodialysis (artificial kidney) in acute poisoning. Arch. Intern. Med. (Chicago) 102: 896, 1958. CrossrefGoogle Scholar3. OHLSSONFRISTEDT WTBI: Blood lavage in acute barbiturate poisoning. Lancet 2: 12, 1962. CrossrefMedlineGoogle Scholar4. LASSEN NA: Treatment of severe acute barbiturate poisoning by forced diuresis and alkalinization of the urine. Lancet 2: 338, 1960. CrossrefGoogle Scholar5. 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WADDELL WJ: Metabolic conversion of secobarbital to 5-allyl-5 (3-hydroxy-l-methylbutyl) barbituric acid (abstract). Fed. Proc. 21: 182, 1962. Google Scholar19. RAVENTOS J: Distribution in the body and metabolic fate of barbiturates. J. Pharm. Pharmacol. 6: 217, 1954. CrossrefMedlineGoogle Scholar20. MERRILL JP: Dialytic methods of treatment, in Disease of the Kidney, edited by STRAUSS, M. B., WELT, L. G., Little, Brown and Co., Boston, 1963, p. 226. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New YorkFrom the Rogosin Laboratories, Department of Medicine, The New York Hospital-Cornell Medical Center, New York City, N. Y.This study was supported in part by a grant from the American Heart Association, grant HEO8736 from the U. S. Public Health Service, Bethesda, Md., and grant U-1022 from the Health Research Council of the City of New York.Dr. Lubash was an Established Investigator of the American Heart Association during the time this work was done.Requests for reprints should be addressed to Glenn D. Lubash, M.D., Rogosin Laboratories, The New York Hospital-Cornell Medical Center, 525 East 68th St., New York, N. Y. 10021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEnhanced elimination in acute barbiturate poisoning – A systematic reviewPhysiologic Implications of Mechanical Ventilation on PharmacokineticsSedativ-HypnoticaTreatment of Sedative Drug OverdosePeritoneal Dialysis: A ReviewDialysis of Poisons and DrugsThe Management of the Presuicidal, Suicidal, and Postsuicidal PatientJOSEPH F. ROSS, M.D., F.A.C.P., WILLIAM L. HEWITT, M.D., F.A.C.P., CHARLES W. WAHL, M.D., RONALD OKUN, M.D., BERTRAND J. SHAPIRO, M.D., PAUL F. SLAWSON, M.D., EDWIN S. SHNEIDMAN, Ph.D.HypnoticsDrug-Induced ComaMETHODS OF FORCED DIURESIS AND ITS APPLICATION IN BARBITURATE POISONINGBarbiturate PoisoningA Parting Gift 1 February 1965Volume 62, Issue 2Page: 246-251KeywordsComaDrugsHeartIngestionIntoxicationLongitudinal studiesMedical servicesMetabolitesPeritoneal dialysisToxic agents Issue Published: 1 February 1965 PDF DownloadLoading ...