Bradycardia After Infusion of Atrial Natriuretic Factor
Authors: ROBERTO FRANCO-SUAREZ
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 October 1987Bradycardia After Infusion of Atrial Natriuretic FactorROBERTO FRANCO-SUAREZ, M.D., PITAMBAR SOMANI, M.D., Ph.D., PATRICK J. MULROW, M.D.ROBERTO FRANCO-SUAREZ, M.D.Search for more papers by this author, PITAMBAR SOMANI, M.D., Ph.D.Search for more papers by this author, PATRICK J. MULROW, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-4-594_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We wish to report an episode of sudden bradycardia and sinus arrest after infusion of atrial natriuretic factor.A 41-year-old white woman with a long history of hypertension volunteered to participate in a double-blind placebo control study to assess the effects of 8-33 Met atrial natriuretic factor in patients with hypertension. The infusion of the factor (1.05 µg/m for 4 hours) in this patient caused diuresis, natriuresis, and progressive lowering of the blood pressure with no changes in heart rate. Urine volume was 1100 mL for 4 hours during the placebo, and 1650 mL for 4 hours...References1. SASAKIKIDAKANGAWAMATSUOTANAKA AOKHK. Cardiosuppressive effect of alpha-human atrial natriuretic polypeptide (alpha-hANP) in spontaneously hypertensive rats. Eur J Pharmacol. 1985;115:321-4. CrossrefMedlineGoogle Scholar2. THORENMARKMORGANO'NEILLNEEDLEMANBRODY PADTPM. Activation of vagal depressor reflexes by atriopeptins inhibits renal sympathetic nerve activity. Am J Physiol. 1986;251:H1252-9. MedlineGoogle Scholar3. DEBINSKIKUCHELGARCIA WOR. Atrial natriuretic factor inhibits the sympathetic nervous activity in one-kidney, one-clip hypertension in the rat. Proc Soc Exp Biol Med. 1986;181:173-7. CrossrefMedlineGoogle Scholar4. WALDMANRAPOPORTMURAD SRF. Atrial natriuretic factor selectively activates particulate guanylate cyclase and elevates cyclic GMP in rat tissues. J Biol Chem. 1984;259:1432-4. CrossrefGoogle Scholar5. NICHOLLSRICHARDS MA. Human studies with atrial natriuretic factor. In: Endocrinology and Metabolism Clinics of North America. Philadelphia: W. B. Saunders; 1987:199-223. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medical College of Ohio Toledo, OH 43699 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByElectrophysiological effects of natriuretic peptides in the heart are mediated by multiple receptor subtypesLong-Term Administration of Atrial Natriuretic Peptide in Patients with Acute Heart FailureAtrial Natriuretic Peptide and Cardiac Electrophysiology: Autonomic and Direct EffectsAtrial peptides induce mast cell histamine releaseAtrial natriuretic factor and autonomic nervous system function in manCorrection: Incorrect Spelling of Author's Name in Letter on Atrial Natriuretic Factor 1 October 1987Volume 107, Issue 4Page: 594-594KeywordsAtrial natriuretic peptidesBlood pressureBradycardiaHeart rateHypertensionUrine Issue Published: 1 October 1987 PDF DownloadLoading ...