Neopterin Levels correlating with the Walter Reed Staging Classification in Human Immunodeficiency Virus (HIV) Infection
Authors: Dietmar Fuchs, Gilbert Reibnegger, Helmut Wachter, Hans Jaeger, Matei Popescu, Werner Kaboth
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 November 1987Neopterin Levels correlating with the Walter Reed Staging Classification in Human Immunodeficiency Virus (HIV) InfectionDIETMAR FUCHS, Ph.D., GILBERT REIBNEGGER, D.SC., HELMUT WACHTER, Ph.D., HANS JAEGER, M.D., MATEI POPESCU, M.D., WERNER KABOTH, M.D.DIETMAR FUCHS, Ph.D.Search for more papers by this author, GILBERT REIBNEGGER, D.SC.Search for more papers by this author, HELMUT WACHTER, Ph.D.Search for more papers by this author, HANS JAEGER, M.D.Search for more papers by this author, MATEI POPESCU, M.D.Search for more papers by this author, WERNER KABOTH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-5-784_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Neopterin has been identified as a potential marker in the acquired immunodeficiency syndrome (AIDS) (1). We have tested 49 men in different stages of the Walter Reed staging classification (2) for neopterin concentrations in serum and urine. Forty-six men were homosexuals and 3 were parenteral drug addicts. They were repeatedly tested up to five times, at regular intervals of 2 weeks during a period of 3 months. In total, 208 serum samples and 160 urine specimens were evaluated. Neopterin was measured in urine samples by high-performance liquid chromatography techniques (3) and in serum by a commercially available...References1. WACHTERFUCHSHAUSEN HDA. Elevated urinary neopterin levels in patients with the acquired immunodeficiency syndrome (AIDS). Z Physiol Chem. 1983;364:1345-6. CrossrefMedlineGoogle Scholar2. REDFIELDWRIGHTTRAMONT RDE. The Walter Reed staging classification for HTLV-III/LAV infection. N Engl J Med. 1986;314:131-2. CrossrefMedlineGoogle Scholar3. HAUSENFUCHSKÖNIGWACHTER ADKH. Determination of neopterin in human urine by reversed-phase high-performance liquid chromatography. J Chromatogr. 1982;227:61-70. CrossrefMedlineGoogle Scholar4. WERNERBICHLERDAXENBICHLER EAG. Determination of neopterin in serum and urine. Clin Chem. 1987;33:62-6. CrossrefMedlineGoogle Scholar5. HUBERBATCHELORFUCHS CJD. Immune response-associated production of neopterin—release from macrophages primarily under control of interferon-gamma. J Exp Med. 1984;160:310-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DIETMAR FUCHS, Ph.D.; GILBERT REIBNEGGER, D.SC.; HELMUT WACHTER, Ph.D.; HANS JAEGER, M.D.; MATEI POPESCU, M.D.; WERNER KABOTH, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIncreased serum neopterin in patients with HIV-1 infection is correlated with reduced in vitro interleukin-2 productionInduction of Afoptosis by 7 ,8-Dihydroneopterin: Involvement of Radical FormationNeopterin: a reviewIncreased Efficacy of Human Natural Interferon α (IFN-αn3) Versus Human Recombinant IFN-α2 for Inhibition of HIV-1 Replication in Primary Human MonocytesPathogenesis, Natural History, and Classification of HIV InfectionMediator release in cerebrospinal fluid of human immunodeficiency virus-positive patients with central nervous system involvementPATHOGENESIS, NATURAL HISTORY, AND CLASSIFICATION OF HIV INFECTIONThe Role of Neopterin as a Monitor of Cellular Immune Activation in Transplantation, Inflammatory, Infectious, and Malignant DiseasesLaboratory Diagnosis of Retroviral InfectionsInterferon-Alpha and Tumor Necrosis Factor-Alpha in Serum of Patients in Various Stages of HIV-1 InfectionNeopterin and β2-microglobulin as prognostic indices in human immunodeficiency virus type 1 infectionSerologic and immunologic markers in the course of HIV-1 infectionEnvironmental effects on the human immune system and the risk of cancer: Facts and fears in the era of AIDSSerum Neopterin Levels Following Intravenous Endotoxin Administration to Normal HumansCharacterization of Borrelia burgdorferi Associated Antigens by Monoclonal AntibodiesCerebrospinal fluid neopterin in human immunodeficiency virus type 1 infectionMicronutrient Status and Human Immunodeficiency Virus (HIV) InfectionThe role of interferons in the control of HIV replication in macrophagesInterleukin-2- and neopterin-induced neopterin release from peripheral blood mononuclear cellsLaboratory Diagnosis of Human Immunodeficiency Virus InfectionThe effect of immunomodulators on PHA or γ-IFN induced release of neopterin from purified macrophages and peripheral blood mononuclear cellsNeopterin as Marker for Activation of Cellular Immunity: Immunologic Basis and Clinical ApplicationNeopterin as a marker for activated cell-mediated immunity: Application in HIV infection 1 November 1987Volume 107, Issue 5Page: 784-785KeywordsAIDSAddictsAttentionChromatographyHIVHIV infectionsHomosexualsUrine ePublished: 1 December 2008 Issue Published: 1 November 1987 PDF downloadLoading ...