tbuckley/cabot-search huggingface dataset:
Interpreting Whole-Genome Sequencing
Authors: Wayne W. Grody, Eric Vilain, Stanley F. Nelson
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Governor Indorses Dr. Souchon.
Authors: Newton C. Blanchard
Journal: JAMA (1906)

New Orleans, Dec. 23, 1905. <h3>To the Editor:</h3> —I enclose a copy of the letter written me by Governor Blanchard of Louisiana in connection with his acceptance of my resignation. The letter speaks for itself. Edmond Souchon, M.D. New Orleans, Dec. 23, 1905. Dr. Edmond Souchon, City. <h3>My Dear Doctor:</h3> —Several weeks ago you tendered to me as governor of the state your resignation, both as president and member of the State Board of Health. This action on your part, as also that of the other members of the state board was, I am sure, prompted by a desire on your part to avoid all difficulty in the way of a reorganization of the board, and thereby to remove certain embarrassments of the state administration that had grown up out of unfortunate conditions that had arisen. In accepting your resignation permit me to assure you that I do not share
METABOLIC SYNDROME, DIABETES MELLITUS, OR BOTH AND CARDIOVASCULAR RISK IN OUTPATIENTS AT RISK OF OR WITH ATHEROTHROMBOSIS IN THE REACH REGISTRY
Authors: Jacob A. Udell, Philippe Steg, Benjamin Scirica, Kim Eagle, Erik Ohman, Shinya Goto, Jang Ik Cho, Peter Wilson, Deepak Bhatt
Journal: Journal of the American College of Cardiology (2012)
Single-cell genetic analysis reveals the composition of initiating clones and phylogenetic patterns of branching and parallel evolution in myeloma
Authors: L Melchor, A Brioli, C P Wardell, A Murison, N E Potter, M F Kaiser, R A Fryer, D C Johnson, D B Begum, S Hulkki Wilson, G Vijayaraghavan, I Titley, M Cavo, F E Davies, B A Walker, G J Morgan
Journal: Leukemia (2014)
Topical ampicillin in the appendicectomy wound: Report of double-blind trial
Authors: J. W. S. Rickett, B. T. Jackson
Journal: BMJ (1969)

One hundred and thirty unselected patients undergoing appendicectomy were treated with topical ampicillin powder or topical placebo powder (lactose) before closing the wound. The postoperative wound infection rates were 3% in the ampicillin-treated group and 24% in the control group, a significant difference. This difference was not influenced by the degree of inflammation in the appendix. No side-effects of treatment were observed.
Massive Uptake of Tc-99m MDP in Mucinous Adenocarcinoma of the Colon Metastatic to Liver
Authors: E. W. HUDSON, GILBERT A. HURWITZ, SORAYA A. ALI
Journal: Clinical Nuclear Medicine (1993)

Tc-99m MDP uptake has been described in mucinous adenocarcinoma metastatic to the liver. Uptake is demonstrated in a very large metastatic focus on SPECT imaging in a patient who has survived for 3 years after primary resection and 1 year after diagnosis of liver metastasis.
Analysis of the <i>REL</i> polymorphism rs13031237 in autoimmune diseases
Authors: Jezabel Varadé, Rogelio Palomino-Morales, Norberto Ortego-Centeno, Manuel Díaz-Rubio, Benjamín Fernández-Gutiérrez, Miguel Ángel González-Gay, Dora Pascual-Salcedo, Alejando Balsa, Antonio Iglesias, María Gómez-García, Torsten Witte, Timothy R D J Radstake, Marieke J H Coenen, Elena Urcelay, Javier Martín
Journal: Annals of the Rheumatic Diseases (2010)

REL encodes the c-rel protein, a member of the nuclear factor-κB family of transcription factors involved in the autoimmune response via regulation of the expression of cytokines, anti-apoptotic molecules and cell cycle modulators.1 Expression of c-rel, which is restricted to mature haematopoietic cells, has been described in patients with systemic lupus erythematosus (SLE) and inflammatory bowel disease.2 3 Associations of the REL gene with celiac disease4 and rheumatoid arthritis (RA)5 have been reported. Moreover, Rel knockout mice do not develop autoimmune diseases such as experimental autoimmune encephalomyelitis,6 collagen-induced arthritis or type I diabetes.7

Last year Gregersen et al described the association of the intronic single nucleotide polymorphism (SNP) rs13031237G→T in the REL gene as a risk factor for RA in an expansion of previous genome-wide association …
MENTAL THERAPEUTICS AND THE NEED OF PSYCHOLOGY IN THE MEDICAL CURRICULUM.
Authors: HOWELL T. PERSHING
Journal: JAMA (1902)

Every illness is a factor simple or complex, which is multiplied by a second factor, invariably complex—the individual who is suffering from it. The doctor who does not read you to the bottom is ignorant of essentials. To me the ideal doctor would be a man endowed with profound knowledge of life and of the soul, intuitively divining any suffering of whatever kind, and restoring peace by his mere presence. Such a doctor is possible.—<i>Amiel's Journal.</i> Physicians need no argument to show that purely physical processes may cause profound mental changes. Every case of lesion of the brain, every delirious fever patient, every exhilarated banqueter, furnishes a fresh illustration of the fact. The converse proposition, that purely mental processes may cause profound physical changes, still excites a tendency to doubt or wonder, but it is just as true and special instances are just as familiar. The blanched face, chattering
AASLD practice guidelines on chronic hepatitis B and HBV infection in Italy
Authors: Tommaso Stroffolini, Giovanni Battista Gaeta, Alfonso Mele
Journal: Hepatology (2007)

We read with interest the AASLD Practice Guidelines on chronic hepatitis B recently published in HEPATOLOGY.1 Table 2 of the guidelines reports groups at high risk for hepatitis B virus (HBV) infection who should be screened. Individuals born in Italy are included on the assumption that Italy is a country at intermediate prevalence (2%-7%) of hepatitis B surface antigen (HBsAg) carriers in the general population. Moreover, (at page 510) in the section "Natural history of chronic HBV infection" it is stated that in Mediterranean countries (including Italy) "transmission of HBV usually occurs from person to person during childhood". The incidence rate of acute B hepatitis decreased from 12 of 100,000 inhabitants in 1985 to 1.3 of 100,000 inhabitants in 2005 (Fig. 1). The HBsAg prevalence in the general population is largely below 2%, because the prevalence of HBsAg was 0.6% in 7405 subjects 3-19 years of age during the second half of the 1980s,2 1.6% in a national sample of 4993 recruits aged 18-26 years in 1990,3 1.4 % in 9929 pregnant women from 6 Italian regions in 2001,4 and largely below 1% among all age groups in population-based surveys performed in the second half of the 1990s in different Italian areas.5 At present, acute hepatitis B in Italy is mostly a sexually transmitted disease, as more than half of the cases report 2 or more sexual partners in the period of 6 months before onset of the disease.6 Child-to-child transmission is almost absent, because hepatitis B vaccine is compulsory by law in Italy for 3-month-old infants since 1991, reaching a very high coverage. As a consequence of the declined trend of HBV endemicity in the last decades, a survey performed in 79 Italian hospitals in 2001 has shown that among 10,000 subjects affected by chronic liver diseases, only 10% tested HBsAg-positive.7 Incidence cases × 100,000 inhabitants of acute B hepatitis in Italy. SEIEVA; Integrated Epidemiologic System for Acute Viral Hepatitis, 1985-2005. On the basis of the reported findings, Italy is a country with a low endemic level of HBV infection. Accordingly, it does not seem advisable that individuals born in Italy should be screened for HBV infection, unless they belong to specific high-risk groups. Tommaso Stroffolini* , Giovanni Battista Gaeta , Alfonso Mele*, * National Health Institute, Rome, Italy, Department of Gastroenterology, San Giacomo Hospital, Rome, Italy, Department of Infectious Diseases, University of Naples, Italy.
TRANSIENT MONOCULAR BLINDNESS.
Authors: WILLIAM CAMPBELL POSEY
Journal: JAMA (1902)

Apart from the momentary blurring of vision from a tired ciliary muscle, or the partial blindness which accompanies migraine, or the periodic dimness of sight which is so frequent a precursor of glaucoma, transient loss of vision limited to one eye is very uncommon. The attention of the writer was first called to this symptom some years ago by a patient, an elderly clergyman, who was brought to the office in a great state of perturbation by a friend, on account of the sudden loss of sight in the right eye. The blindness was complete for about fifteen minutes and then began to clear, so that by the time the office of the writer was reached, about half an hour after the commencement of the attack, sight was fully restored. A careful ophthalmoscopic examination was at once made, but failed to reveal any cause for the blindness, other than changes
Abstract 1783: Insights into Delayed Potential Detection by High Resolution Scar Mapping of Life Threatening Ventricular Arrhythmias in Patients with Ischemic Cardiomyopathy
Authors: Kentaro Yoshida, Kazutaka Aonuma, Kenji Kuroki, Hiro Yamasaki, Kazuyuki Tanoue, Miyako Kanemoto, Akihiro Suzuki, Masae Endo, Keisuke Kuga, Yukio Sekiguchi, Yasuteru Yamauchi, Yasuhiro Yokoyama, Atsushi Takahashi, Iwao Yamaguchi
Journal: Circulation (2006)
Dysfunctional ischemic preconditioning mechanisms in aging
Authors: S Pepe
Journal: Cardiovascular Research (2001)

See article byTani et al. [7] ( pages 56 -68) in this ergic, bradykinin, endothelin, angiotensin, d-opioid peptide issue.and muscarinic receptors [9-15].Activation of specific G-proteins (depending on the respective G-protein-coupled receptor type) causes generation of inositol (1,4,5) tris-1.Introduction phosphate (IP ) and diacylglycerol, the endogenous sub-3 strate for PKC activation via the classical phospholipase With increased age, the adult heart undergoes numerous activation pathway [16].IP has been shown to activate IP 3 3 anatomical, ultrastructural and biochemical changes which receptors on the sarcoplasmic reticulum of cardiac remodel cellular structure, function and the intracellular myocytes [17].Although it is unclear whether IP has a 3 adaptive response to pathological stress [1-6].Compared role in ischemic preconditioning, recently it has been to young adult myocardium, the senescent myocardium has reported that preconditioning evokes a biphasic fluctuation a reduced capacity to tolerate post-ischemic perturbations in myocardial IP , with an increase in IP during ischemic 3 3 in intracellular metabolism and ion homeostasis [1-6].In preconditioning and a decrease during sustained ischemia this issue of Cardiovascular Research, Tani et al. [7][18].Notably, treatment with an IP agonist followed by an 3 report that there is an age-linked functional decline in IP antagonist has been reported to mimic the protective 3 1 3 1(MAPK) and p38-MAPK signaling [29,30].Since the discovery of K channels in mitochondria
Appointment of Preregistration House Officers
Authors: J. Alexander-Williams, I. G. Stephenson
Journal: BMJ (1973)

A new programme to try and match the preferences of students and consultants in preregistration appointments has been designed after a survey of student opinion. It is based on five main principles: a standardized change-over date for posts; holding only one post in a teaching hospital; separate application for house physician and house surgeon appointments; application six months before the post becomes vacant; and two rounds for matching preferences. The programme has now been working successfully for a year and experience suggests that the ideal administrative size for it is that of a region or area health authority.
Morphological and histochemical analyses of two human T-cell subpopulations bearing receptors for IgM or IgG.
Authors: C E Grossi, S R Webb, A Zicca, P M Lydyard, L Moretta, M C Mingari, M D Cooper
Journal: The Journal of Experimental Medicine (1978)

Two subpopulation of circulating human T cells forming rosettes with neuraminidase-treated sheep erythrocytes were purified on the basis of the presence of receptors for IgG (TG cells) or for IgM (TM cells), and were shown to have distinguishing morphological and histochemical characteristics. TM cells had the general features of typical small- or medium-sized lymphocytes; most were easily identifiable by distinctive cytoplasmic accumulations, usually one and sometimes two large spots, of nonspecific acid esterase activity. The release of the vesicular contents on short-term culture of TG cells was inhibited by cytochalasin B. Definition of these distinguishing characteristics of TM and TG cells provides a basis for practical enumeration of these functionally distinct subpopulations of human T cells. Some of the TG cells were capable of endocytosis of IgG antibody-coated erythrocytes.
The Effect of Low-Dose Continuous Estrogen and Progesterone Therapy with Calcium and Vitamin D on Bone in Elderly Women
Authors: Robert R. Recker
Journal: Annals of Internal Medicine (1999)

Background: Hormone replacement therapy (HRT), the mainstay of osteoporosis prevention, is limited because of dose-related risks, side effects, and patient acceptance. The bone-sparing efficacy and tolerability of the lowest available doses of HRT have not been adequately studied in elderly women. Objective: To determine the bone-sparing effect of continuous low-dose HRT in elderly women. Design: Randomized, double-blind, placebo-controlled trial. Setting: University osteoporosis research and clinical center. Patients: 128 healthy white women (age > 65 years) with low bone mass recruited by word of mouth and by local advertisement. The principal eligibility criterion was spinal bone mineral density of 0.90 g/cm2 or less. Intervention: Continuous therapy with conjugated equine estrogen, 0.3 mg/d, and medroxyprogesterone, 2.5 mg/d, or matching placebo. Sufficient calcium supplementation was given to bring all calcium intakes above 1000 mg/d in both groups; supplemental oral 25-hydroxyvitamin D was given to maintain serum 25-hydroxyvitamin D levels of at least 75 nmol/L in both groups. Measurements: Bone mineral density of the spine, hip, total body, and forearm; serum total alkaline phosphatase and serum osteocalcin levels at 6-month intervals; and 24-hour urine creatinine and hydroxyproline excretion at baseline, 12 months, and 42 months. Results: During 3.5 years of observation, spinal bone mineral density increased by 3.5% (P < 0.001) in an intention-to-treat analysis and by 5.2% among patients with greater than 90% adherence to therapy. Significant increases were seen in total-body and forearm bone density (P < 0.01). Symptoms related to HRT (breast tenderness, spotting, pelvic discomfort, and mood changes) were mild and short-lived. Conclusions: Continuous low-dose HRT with conjugated equine estrogen and oral medroxyprogesterone combined with adequate calcium and vitamin D provides a bone-sparing effect that is similar or superior to that provided by other, higher-dose HRT regimens in elderly women. This combination is well tolerated by most patients.
Enhancing Performance Measurement
Authors: Eric C. Schneider, Virginia Riehl, Sonja Courte-Wienecke, David M. Eddy, Cary Sennett
Journal: JAMA (1999)

Measuring the quality of health care delivery is one of the most critical challenges facing US health care. Performance measurement can be used to track the quality of care that health plans and medical groups deliver, but effective performance measurement requires timely access to detailed and accurate data. In 1996, the National Committee for Quality Assurance (NCQA) commissioned a report to learn what actions would improve health plans' capacity to electronically report performance data for the Health Plan Employer Data and Information Set (HEDIS). Tracking clinical performance will require not just clinical data stored in information systems, but an integrated health information framework. Seven features are essential to this framework: (1) it specifies data elements; (2) it establishes linkage capability among data elements and records; (3) it standardizes the element definitions; (4) it is automated to the greatest possible extent; (5) it specifies procedures for continually assessing data quality; (6) it maintains strict controls for protecting security and confidentiality of the data; and (7) it specifies protocols for sharing data across institutions under appropriate and well-defined circumstances. Health plans should anticipate the use of computerized patient records and prepare their data management for an information framework by (1) expanding and improving the capture and use of currently available data; (2) creating an environment that rewards the automation of data; (3) improving the quality of currently automated data; (4) implementing national standards; (5) improving clinical data management practices; (6) establishing a clear commitment to protecting the confidentiality of enrollee information; and (7) careful capital planning. Health care purchasers can provide the impetus for implementing the information framework if they demand detailed, accurate data on the quality of care.
A Comparative Study of the Biliary Secretion of Human Dimeric and Monomeric IgA in the Rat and in Man
Authors: James S. Dooley, Barry J. Potter, Howard C. Thomas, Sheila Sherlock
Journal: Hepatology (1982)

In the rat, dimeric immunoglobulin A (dIgA) is cleared rapidly from the systemic circulation into bile by vesicular transport through the hepatocyte. Whether such transfer of dIgA occurs in man is controversial. The fate of dIgA and monomeric IgA (mIgA) was studied in rats with biliary drainage, and in parallel in 4 patients, 3 of whom had biliary drainage. Human dIgA and mIgA were prepared from myeloma sera and labeled with radioisotopes of iodine. Ten microcuries each of 125 I–dIgA and 131 I–mIgA (2 to 4μg protein) were given i.v. simultaneously. In the four patients, 125 I–dIgA disappeared more rapidly from the serum than did 131 I–mIgA. Biliary recovery of 125 I–dIgA (expressed as per cent total dose given) was only 0.2 to 0.9% in 8 hr while that of 131 I–mIgA was 0.1 to 0.2%. In contrast, biliary recovery over the same period in rats was 21 to 32% for l25 I–dIgA and 3.0 to 4.6% for 131 I–mIgA. The data show that in man after injection of a trace amount of human myeloma IgA, rapid transport of dIgA into bile, as observed in the rat, was not seen. Although selective transport of dIgA over mIgA into bile occurred in man, the total amount of dIgA transported was small, and it is suggested that under physiological conditions, the major part of human biliary IgA is derived from local synthesis.
Initiation of Thyroid-Hormone Action
Authors: Howard L. Bleich, Emily S. Boro, Jack H. Oppenheimer
Journal: New England Journal of Medicine (1975)

ALTHOUGH the biologic importance of the thyroid gland has been recognized for the past century, the properties of the hormone are still understood in terms of the diverse and apparently unrelated physiologic and biochemical derangements that characterize the hypothyroid and hyperthyroid states. In part, the relatively slow progress in elucidation of the molecular basis of thyroid-hormone action can be attributed to the lack of a well defined set of target tissues and to the lack of a universally recognized model for in vitro study of the biochemistry of the hormone's effects.During the past two years, however, the recognition of . . .
CEREBRO-SPINAL CONCUSSION
Authors: D. Noble
Journal: BMJ (1855)

she had worn the applications without inconvenience, but wished to have the substance removed, if possible.Accord- ingly, on the 3rd, Mr. Carden, with the view of getting the body into the cellular tisue surroundi-ng the joint, pre- viously to its complete removal, made a su cutaneous divi- sion of the synovial membrane on the upper and outer side of the joint, the body being firmly pressed in the same direction; instead, however, of its starting from the joint, and lying in the cellular tissue outside, it appeared to be retained by some adhesion in its present position; and as
The Arts in Medical Education: A Practical Guide
Authors: Liam Farrell
Journal: BMJ (2005)

Elaine Powley, Roger Higson Radcliffe, £40, pp 160 ISBN 1 85775 626 6 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> The older I get the more in awe I become of the achievements of scientific medicine. I also have personal reasons to be grateful, as my little Gracie had an atrial septal defect (ASD) and only a few years ago she would have been condemned to a life of progressive disability. But, thanks to the incredible skill and care from Dr Frank Casey and his team at the Royal Hospital for Sick Children in Belfast, she is now as healthy and happy and cheeky as any other 7 year old. Her ASD was closed by angiography; a simple statement, but just imagine for a moment the number of … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
RECONSTRUCTION AND PLASTIC OPERATIONS ON THE HIP
Authors: FRED H. ALBEE
Journal: JAMA (1925)

No other joint offers so great an opportunity for the bone surgeon to indulge his ingenuity as does the hip. Yet there is probably no large joint in which less surgery was undertaken, until the last decade. In fact, although arthrodesis of the knee joint for tuberculosis and other conditions had been frequently undertaken by a large number of surgeons for many years, no one had attempted to devise an operation to arthrodese the hip joint until I brought forward this operation<sup>1</sup>for advanced arthritis deformans (ostearthritis) in 1908. <h3>THE MODERN ARMAMENTARIUM</h3> Four influences—the technically facile fracture orthopedic table, the bone mill, the Smith-Petersen approach to the joint, and the possibility of bone grafting—have led to the development of the extensive amount of plastic operations on the hip now possible, the limits of which to a large degree depend on the ingenuity and experience of the operating surgeon. The
Novel lamin A/C mutations in idiopathic dilated cardiomyopathy and/or conduction disease
Authors: Peter van Tintelen, Hilga Katerberg, Ludolf Boven, Ans Wiesfeld, Arthur A. Wilde, Irene M. van Langen, Tom Rossenbacker, Maarten P. van den Berg, Dirk J. van Veldhuisen, Charles H. Buys, Robert Hofstra, Yvonne Vos
Journal: Journal of the American College of Cardiology (2003)
TCT-325 Patients skin radiation doses in a contemporary cohort of patients undergoing percutaneous interventional cardiology procedures
Authors: Juan Nogales-Asensio, Sara Sánchez, Ana Martinez, Maria Yuste, Jose Ordiales, Jose Lopez-Minguez, Reyes González, Antonio Merchan, Ginés Martínez, Francisco Diaz-Cortegana, Laura Garcia-Serrano
Journal: Journal of the American College of Cardiology (2012)