tbuckley/cabot-search huggingface dataset:
Cognitive Development After the Fontan Operation
Authors: Gil Wernovsky, Karen M. Stiles, Kimberlee Gauvreau, Thomas L. Gentles, Adre J. duPlessis, David C. Bellinger, Amy Z. Walsh, Janice Burnett, Richard A. Jonas, John E. Mayer, Jane W. Newburger
Journal: Circulation (2000)

Patients with a single ventricle have multiple risk factors for central nervous system injury, both before and after the Fontan procedure.A geographically selected cohort was invited to undergo standardized testing, including age-appropriate measures of intelligence quotient (IQ) and achievement tests. Historical information was obtained by chart review and patient questionnaires. Of the 222 eligible patients, 133 (59.9%) participated. Median age at testing was 11.1 years (range, 3. 7 to 41.0 years), 6.0 years (range, 1.6 to 19.6 years) after surgery. Mean full-scale IQ was 95.7+/-17.4 (P<0.006 versus normal); 10 patients (7.8%) had full-scale IQ scores <70 (P=0.001). After adjustment for socioeconomic status, lower IQ was associated with the use of circulatory arrest before the Fontan operation (P=0.002), the anatomic diagnoses of hypoplastic left heart syndrome (P<0.001) and "other complex" (P=0.05), and prior placement of a pulmonary artery band (P=0.04). Mean composite achievement score was 91.6+/-15. 4 (P<0.001 versus normal); 14 patients (10.8%) scored <70 (P<0.001). After adjustment for socioeconomic status, independent risk factors for low achievement scores included the diagnoses of hypoplastic left heart syndrome (P=0.004) and "other complex" (P=0.003) or prior use of circulatory arrest (P=0.03), as well as a reoperation with cardiopulmonary bypass within 30 days of the Fontan (P=0.01).Most individual patients palliated with the Fontan procedure in the 1970s and 1980s have cognitive outcome and academic function within the normal range, but the performance of the cohort is lower than that of the general population.
NHS 111 led to more ambulance dispatches, finds study
Authors: Z. Kmietowicz
Journal: BMJ (2013)

The NHS 111 urgent care telephone service increased the use of ambulances in England during its first year of operation—contrary to what it was designed to do—shows an evaluation of pilot sites published in BMJ Open .1

The Department of Health commissioned the study to evaluate NHS 111, the new 24 hour telephone service to manage all requests for urgent help, including those for GP out of hours services and urgent problems that may need an ambulance. The service is staffed by non-clinicians who use an algorithm based assessment system, NHS Pathways, to triage calls to other services or care …
A retrospective observational study of primary cutaneous malignant melanoma patients treated with excision only compared with excision biopsy followed by wider local excision
Authors: D.B. Mckenna, R.J. Lee, R.J. Prescott, V.R. Doherty
Journal: British Journal of Dermatology (2004)

Journal Article A retrospective observational study of primary cutaneous malignant melanoma patients treated with excision only compared with excision biopsy followed by wider local excision Get access D.B. Mckenna, D.B. Mckenna Department of Dermatology, Royal Infirmary of Edinburgh, EH3 9WY, Scotland, U.K. *Medical Statistics Unit, University of Edinburgh, EH8 9AG, Scotland, U.K Dr D.B.McKenna. E‐mail: dermotbmckenna@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar R.J. Lee, R.J. Lee Department of Dermatology, Royal Infirmary of Edinburgh, EH3 9WY, Scotland, U.K. *Medical Statistics Unit, University of Edinburgh, EH8 9AG, Scotland, U.K Search for other works by this author on: Oxford Academic Google Scholar R.J. Prescott, R.J. Prescott Department of Dermatology, Royal Infirmary of Edinburgh, EH3 9WY, Scotland, U.K. *Medical Statistics Unit, University of Edinburgh, EH8 9AG, Scotland, U.K Search for other works by this author on: Oxford Academic Google Scholar V.R. Doherty V.R. Doherty Department of Dermatology, Royal Infirmary of Edinburgh, EH3 9WY, Scotland, U.K. *Medical Statistics Unit, University of Edinburgh, EH8 9AG, Scotland, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 150, Issue 3, 1 March 2004, Pages 523–530, https://doi.org/10.1111/j.1365-2133.2004.05849.x Published: 01 March 2004 Article history Accepted: 16 September 2003 Published: 01 March 2004
Familial hypertryptasemia with associated mast cell activation syndrome
Authors: Vito Sabato, Els Van De Vijver, Margo Hagendorens, Inge Vrelust, Edwin Reyniers, Erik Fransen, Chris Bridts, Luc De Clerck, Geert Mortier, Peter Valent, Didier Ebo
Journal: Journal of Allergy and Clinical Immunology (2014)
Reply to Riccardo Autorino, Robert J. Stein and Jihad H. Kaouk’s Letter to the Editor re: Luca Cindolo, Stefano Gidaro, Fabiola R. Tamburro, Luigi Schips. Laparo-Endoscopic Single-Site Left Transperitoneal Adrenalectomy. Eur Urol 2010;57:911–4
Authors: Luca Cindolo, Stefano Gidaro, Fabiola R. Tamburro, Luigi Schips
Journal: European Urology (2009)
High-Risk Human Papillomavirus–Positive Lung Cancer: Molecular Evidence for a Pattern of Pulmonary Metastasis
Authors: Robert A.A. van Boerdonk, Johannes M.A. Daniels, Elisabeth Bloemena, Oscar Krijgsman, Renske D.M. Steenbergen, Ruud H. Brakenhoff, Katrien Grünberg, Bauke Ylstra, Chris J.L.M. Meijer, Egbert F. Smit, Peter J.F. Snijders, Daniëlle A.M. Heideman
Journal: Journal of Thoracic Oncology (2013)
A METHOD FOR WASHING FIXED TISSUE
Authors: Bernard G. H. Thomas
Journal: JAMA (1925)

In the preparation of good histologic sections for microscopic examination, it is essential that all tissue fixed in Zenker's solution or other fixatives containing bichromate should be thoroughly washed in water. None of the methods used were found to be entirely satisfactory, and it occurred to me that a tea ball might answer the purpose. It fulfilled the requirements and has been found to be very convenient. The tea ball is of the conventional aluminum type that screws together and has a chain with a hook fastened to the top. The ball containing the tissue is simply placed in a vessel of running water, with the hook fastened on the side. With this device, the specimens can be thoroughly washed without injury. The identification tag can either be placed with the tissue or be fastened on the chain. The ball is cheap and easily cleaned.
THE TRP719ARG VARIANT OF KIF6 AND CARDIOVASCULAR OUTCOMES IN STATIN-TREATED, CORONARY STABLE PATIENTS OF THE TNT AND IDEAL PROSPECTIVE STUDIES
Authors: Benoit Arsenault, S. Matthijs Boekholdt, G. Kees Hovingh, Craig L. Hyde, David A. DeMicco, Aurobindo L. Chatterjee, Philip Barter, Prakash Deedwania, David D. Waters, John C. LaRosa, Terje R. Pedersen, John JP Kastelein
Journal: Journal of the American College of Cardiology (2011)
Variations in the CCL20 and CCR6 Genes are Associated with Atopic Dermatitis and Eczema Herpeticum in Populations of European and African descent.
Authors: N.M. Rafaels, L.A. Beck, P.S. Gao, T. Hand, M. Boguniewicz, T.R. Hata, L. Schneider, J.M. Hanifin, R.L. Gallo, L. Gao, M. Yang, T.H. Beaty, D.Y. Leung, K.C. Barnes
Journal: Journal of Allergy and Clinical Immunology (2009)
Nuclear ErbB2 Enhances Translation and Cell Growth by Activating Transcription of Ribosomal RNA Genes
Authors: Long-Yuan Li, Hsiuyi Chen, Yi-Hsien Hsieh, Ying-Nai Wang, Hsiao-Ju Chu, Ya-Huey Chen, Hui-Yu Chen, Peng-Ju Chien, Haou-Tzong Ma, Ho-Cheng Tsai, Chien-Chen Lai, Yuh-Pyng Sher, Huang-Chun Lien, Chang-Hai Tsai, Mien-Chie Hung
Journal: Cancer Research (2011)

Aberrant regulation of rRNA synthesis and translation control can facilitate tumorigenesis. The ErbB2 growth factor receptor is overexpressed in many human tumors and has been detected in the nucleus, but the role of nuclear ErbB2 is obscure. In this study, we defined a novel function of nuclear ErbB2 in enhancing rRNA gene transcription by RNA polymerase-I (RNA Pol I). Nuclear ErbB2 physically associates with β-actin and RNA Pol I, coinciding with active RNA Pol I transcription sites in nucleoli. RNA interference-mediated knockdown of ErbB2 reduced pre-rRNA and protein synthesis. In contrast, wild-type ErbB2 augmented pre-rRNA level, protein production, and cell size/cell growth, but not by an ErbB2 mutant that is defective in nuclear translocation. Chromatin immunoprecipitation assays revealed that ErbB2 enhances binding of RNA Pol I to rDNA. In addition, ErbB2 associated with rDNA, RNA Pol I, and β-actin, suggesting how it could stimulate rRNA production, protein synthesis, and increased cell size and cell growth. Finally, ErbB2-potentiated RNA Pol I transcription could be stimulated by ligand and was not substantially repressed by inhibition of PI3-K and MEK/ERK (extracellular signal regulated kinase), the main ErbB2 effector signaling pathways. Together, our findings indicate that nuclear ErbB2 functions as a regulator of rRNA synthesis and cellular translation, which may contribute to tumor development and progression.
Theophylline Attenuates Eosinophil Adhesion To Interferon (IFN)-gamma-stimulated Endothelial Cells
Authors: T. Soma, K. Nakagome, T. Kobayash, Y. Takaku, T. Yamaguchi, K. Hagiwara, M. Kanazawa, M. Nagata
Journal: Journal of Allergy and Clinical Immunology (2010)
Trasicor in Angina Pectoris: a Double-blind Trial
Authors: D. F. Wilson, O. F. Watson, J. S. Peel, A. S. Turner
Journal: BMJ (1969)

Eighteen patients entered a double-blind trial of the beta-adrenergic blocking drug Trasicor in the treatment of angina pectoris. Six patients had to be withdrawn from the trial when substitution of placebo for Trasicor caused severe exacerbation of angina attacks. In these cases the frequency and severity of angina attacks fell to a minimum when Trasicor was re-established. A further 10 patients were significantly improved by Trasicor. Two patients showed no significant improvement. No side-effects were observed in doses ranging up to 400 mg. daily.
Inappropriateness of randomised trials for complex phenomena
Authors: Andrew Kotaska
Journal: BMJ (2005)

Evidence based medicine: does it make a difference? Use wiselyEditor-The term "evidence based medicine" entered the scientific lexicon only a little more than a decade ago. 1 What caused its remarkable spread, and what are the implications of its broad and rapid diffusion?The team that coined the term at first considered using the phrase "scientific medicine" but rejected it because it implied that other approaches were by definition unscientific. 2However, critics have argued that the term evidence based medicine carries a similar moral valence and linguistic slipperiness. 3 Who could argue against the notion of providing care that integrates individual clinical skill and the best external evidence? 4 Originally developed as a method for teaching medical residents, evidence based medicine is being applied ever more broadly to the organisation and delivery of medical services.Multiple stakeholders now seek to assume its mantle for purposes that often contradict its original intent.Managers, equating lack of evidence with lack of effectiveness, use it as a rationale for cutting services.Industry generates evidence of questionable quality to promote its products.Medical researchers come to believe that they hold a monopoly on generating and interpreting evidence.Evidence based medicine, developed as a means of taming the unscientific and messy world of clinical practice, has itself entered the unscientific and messy world of politics. 5ike any technology, evidence based medicine carries risks and benefits and can be used appropriately or inappropriately.Overly inclusive definitions threaten to deprive the term of meaning, and unchecked use increases the risk of misuse.In the past decade, evidence based medicine has contributed much to how we teach, deliver, and think about clinical services.In the coming decade, we must continue to ensure that it is not only used widely but wisely.
Inflammatory dendritic cells migrate in and out of transplanted chronic mycobacterial granulomas in mice
Authors: Heidi A. Schreiber, Jeffrey S. Harding, Oliver Hunt, Christopher J. Altamirano, Paul D. Hulseberg, Danielle Stewart, Zsuzsanna Fabry, Matyas Sandor
Journal: Journal of Clinical Investigation (2011)

An estimated one-third of the world's population is infected with Mycobacterium tuberculosis, although most affected individuals maintain a latent infection. This control is attributed to the formation of granulomas, cell masses largely comprising infected macrophages with T cells aggregated around them. Inflammatory DCs, characterized as CD11c+CD11b+Ly6C+, are also found in granulomas and are an essential component of the acute immune response to mycobacteria. However, their function during chronic infection is less well understood. Here, we report that CD11c+ cells dynamically traffic in and out of both acute and chronic granulomas induced by Mycobacterium bovis strain bacillus Calmette-Guérin (BCG) in mice. By transplanting Mycobacterium-induced granulomas containing fluorescently labeled CD11c+ cells and bacteria into unlabeled mice, we were able to follow CD11c+ cell trafficking and T cell activation. We found that half of the CD11c+ cells in chronic granulomas were exchanged within 1 week. Compared with tissue-resident DC populations, CD11c+ cells migrating out of granuloma-containing tissue had an unexpected systemic dissemination pattern. Despite low antigen availability, systemic CD4+ T cell priming still occurred during chronic infection. These data demonstrate that surveillance of granulomatous tissue by CD11c+ cells is continuous and that these cells are distinct from tissue-resident DC populations and support T cell priming during both stages of Mycobacterium infection. This intense DC surveillance may also be a feature of Mycobacterium tuberculosis infection and other granuloma-associated diseases.
Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1
Authors: Jean de la Croix Ndong, Alexander J Makowski, Sasidhar Uppuganti, Guillaume Vignaux, Koichiro Ono, Daniel S Perrien, Simon Joubert, Serena R Baglio, Donatella Granchi, David A Stevenson, Jonathan J Rios, Jeffry S Nyman, Florent Elefteriou
Journal: Nature Medicine (2014)
What's New in Electrocardiography
Authors: Victor F. Froelicher
Journal: JAMA (1982)

The contents of this book were presented at an international work-shop of the same name; the aim was to bring together new information about the ECG and help the practicing physician update his or her knowledge about the 12-lead ECG as Continued from p 2597. a diagnostic, therapeutic, and prognostic tool. Some of the subjects include the prognostic value of the ECG, correlation with radionuclide findings during myocardial infarction, bundlebranch block, the short PR interval, pacemaker malfunction, the effects of aging, digitalis, and pulmonary embolism. Other interesting subjects are the diagnosis of myocardial infarction in pacemaker patients and in those with left bundle-branch block, differentiation between supraventricular and ventricular dysrhythmias, and a chapter on Torsade de Pointes. Wellens presents further documentation that a QR or R pattern in V, in patients having a right bundle-branch block during tachycardia helps to pinpoint the origin as ventricular, whereas if there is an
Acute myeloid leukemia of donor origin after allogeneic bone marrow transplantation for precursor T-cell acute lymphoblastic leukemia: Case report and review of the literature
Authors: Kaaren K. Reichard, Qian-Yun Zhang, Lorraine Sanchez, John Hozier, David Viswanatha, Kathryn Foucar
Journal: American Journal of Hematology (2006)

We report a case of donor-derived acute myeloid leukemia (AML) occurring in a 33-year-old man after allogeneic bone marrow transplantation (BMT) for precursor T-cell acute lymphoblastic –leukemia (T-ALL). The cells for BMT were from his human leukocyte antigen (HLA)-matched sister. Fluorescence in-situ hybridization (FISH) analysis showed the AML to be of donor origin (i.e., karyotypically female) with an 11q23 (mixed lineage leukemia (MLL) gene) translocation, while the original T-ALL exhibited a male karyotype with abnormalities of chromosomes 6, 8, and a t(10;14)(q24;q11.2). Subsequent molecular short tandem repeat studies confirmed the AML to be of donor origin. Donor-cell leukemia (DCL) after allogeneic BMT is a rare, yet well-documented, event. Our report presents clinicopathologic information about a case of DCL and a review of the recent literature. Am. J. Hematol. 81:178–185, 2006. © 2006 Wiley-Liss, Inc.
Abstract 534: Invasive human prostate cancer and integrin cleavage: Potential role of uPAR contributed by macrophages
Authors: Anne E. Cress, Cynthia P. Sandoval, Jaime M.C. Gard, Sangita C. Pawar, Isis C. Sroka, Edward R. Abril, Raymond B. Nagle
Journal: Cancer Research (2010)

Abstract Laminin binding integrins are major determinants of cancer cell migration, invasion and metastasis. Our previous work showed that integrin α6β1 is cleaved on the tumor cell surface by urokinase-type plasminogen activator (uPA), producing a structural variant, α6pβ1. Urokinase plasminogen activator receptor (uPAR) is a regulatory determinant for α6 integrin cleavage since uPAR interacts with integrin and activates uPA. Previous work by others has shown that both human tumor tissue and tumor infiltrating macrophages express uPAR . In the present study, we investigated the potential of uPAR to co-localize with α6β1 integrin in human prostate cancer cells (DU-145) and whether uPAR expressed on the macrophage cell surface mediates integrin α6β1 cleavage. The results indicated uPAR and integrin α6β1 were co-expressed in invasive human prostate carcinoma. Co-localization of uPAR and integrin α6β1 occurred in some tumor cells in vitro, consistent with reports indicating a variable distribution in human tumors. The culture of macrophages with tumor cells resulted in an increased cleavage of integrin α6 as detected by immuno precipitation followed by western blot analysis. Taken together, these data suggest that integrin α6 cleavage is directed by the receptor for uPA, uPAR, contributed either by the tumor cell itself or tumor cell contact with macrophages. (Supported in part by CA 56666, CA23752, T34 GM008718 and the TACMASS core service of the Arizona Cancer Center) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 534.
Ophthalmologic Management of Diabetic Retinopathy
Authors: Peter H. Morse, Theodore G. Duncan
Journal: New England Journal of Medicine (1976)

Diabetic retinopathy ranks as a leading cause of blindness in the United States. Cataracts and glaucoma are largely curable or at least controllable with modern medical and surgical technics. Ability to control diabetic retinopathy and to prevent secondary visual impairment is far less certain. In addition to the totally blind patients with this condition, there are many more who lack sufficient vision to pursue their vocations or avocations. Newer concepts in ophthalmologic methods of diagnosis, evaluation, and treatment appear to offer a greater chance for control and retention of existing vision, with improvement in some cases.Clinical FindingsThe basic . . .
Recent findings on the angioarchitecture of the lymph vessel system of human skin
Authors: D. LUBACH, W. LüDEMANN, D. BERENS VON RAUTENFELD
Journal: British Journal of Dermatology (1996)

The regional distribution of initial (i.e. most peripheral) lymph vessels of the human skin is unknown. New methods permit a precise systematic determination of the density of initial lymph vessels in every region of the dermis. Based on 202 skin specimens, it was possible to investigate the density of the lymph vessels of the skin derived from head, neck, upper arm, forearm, upper and lower leg. In all regions there seem to be a uniform structured dense subpapillary network and a wide meshed deep dermal network. The lymph vessels are at their most dense in the skin of the head.
Cytotoxic Activity of Tivantinib (ARQ 197) Is Not Due Solely to c-MET Inhibition
Authors: Ryohei Katayama, Aki Aoyama, Takao Yamori, Jie Qi, Tomoko Oh-hara, Youngchul Song, Jeffrey A. Engelman, Naoya Fujita
Journal: Cancer Research (2013)

The receptor tyrosine kinase c-MET is the high-affinity receptor for the hepatocyte growth factor (HGF). The HGF/c-MET axis is often dysregulated in tumors. c-MET activation can be caused by MET gene amplification, activating mutations, and auto- or paracrine mechanisms. Thus, c-MET inhibitors are under development as anticancer drugs. Tivantinib (ARQ 197) was reported as a small-molecule c-MET inhibitor and early clinical studies suggest antitumor activity. To assess whether the antitumor activity of tivantinib was due to inhibition of c-MET, we compared the activity of tivantinib with other c-MET inhibitors in both c-MET-addicted and nonaddicted cancer cells. As expected, other c-MET inhibitors, crizotinib and PHA-665752, suppressed the growth of c-MET-addicted cancers, but not the growth of cancers that are not addicted to c-MET. In contrast, tivantinib inhibited cell viability with similar potency in both c-MET-addicted and nonaddicted cells. These results suggest that tivantinib exhibits its antitumor activity in a manner independent of c-MET status. Tivantinib treatment induced a G(2)-M cell-cycle arrest in EBC1 cells similarly to vincristine treatment, whereas PHA-665752 or crizotinib treatment markedly induced G(0)-G(1) cell-cycle arrest. To identify the additional molecular target of tivantinib, we conducted COMPARE analysis, an in silico screening of a database of drug sensitivities across 39 cancer cell lines (JFCR39), and identified microtubule as a target of tivantinib. Tivantinib-treated cells showed typical microtubule disruption similar to vincristine and inhibited microtubule assembly in vitro. These results suggest that tivantinib inhibits microtubule polymerization in addition to inhibiting c-MET.
Recombinant human macrophage colony-stimulating factor (M-CSF) requires subliminal concentrations of granulocyte/macrophage (GM)-CSF for optimal stimulation of human macrophage colony formation in vitro.
Authors: D Caracciolo, N Shirsat, G G Wong, B Lange, S Clark, G Rovera
Journal: The Journal of Experimental Medicine (1987)

Human macrophage colony-stimulating factor (M-CSF or CSF-1), either in purified or in recombinant form, is able to generate macrophagic colonies in a murine bone marrow colony assay, but only stimulates small macrophagic colonies of 40-50 cells in a human bone marrow colony assay. We report here that recombinant human granulocytic/macrophage colony stimulating factor (rhGM-CSF) at concentrations in the range of picograms enhances the responsiveness of bone marrow progenitors to M-CSF activity, resulting in an increased number of macrophagic colonies of up to 300 cells. Polyclonal antiserum against M-CSF did not alter colony formation of bone marrow progenitors incubated with GM-CSF at optimal concentration (1-10 ng/ml) for these in vitro assays. Thus, GM-CSF at higher concentrations (nanogram range) can by itself, elicit macrophagic colonies, and at lower concentrations (picogram range) acts to enhance the responsiveness of these progenitors to M-CSF.