tbuckley/cabot-search huggingface dataset:
CHLOR-ACNE IN RAILWAY WORKERS.
Authors: H. HALDIN-DAVIS
Journal: British Journal of Dermatology (1939)

Journal Article CHLOR‐ACNE IN RAILWAY WORKERS. Get access H. HALDIN‐DAVIS H. HALDIN‐DAVIS Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 51, Issue 8-9, 1 August 1939, Pages 380–383, https://doi.org/10.1111/j.1365-2133.1939.tb10811.x Published: 01 August 1939
Correlates of Vertigo Attacks in Ménière’s Disease
Authors: Christina Hägnebo, Gerhard Andersson, Lennart Melin
Journal: Psychotherapy and Psychosomatics (1998)

&lt;b&gt;Background: &lt;/b&gt;Ménière’s disease is a medical condition that involves hearing loss, tinnitus and attacks of vertigo. The attacks can be severely disabling with nausea, dizziness, and aural sensations. &lt;b&gt;Method: &lt;/b&gt;Three scales assessing the correlates of vertigo attacks in Ménière’s disease were developed and completed by 514 subjects diagnosed with the disease. The three scales measured were somatic sensations (SOM), psychological state (PSYCHOL), and situational characteristics (SIT) associated with an attack. &lt;b&gt;Results:&lt;/b&gt; Psychometric properties of the three scales were investigated showing Cronbach’s alphas of 0.76, 0.80, and 0.62 for the three scales respectively. The results on the scales were related to disease progression. Principal components factor analyses showed that the SOM scale could be divided into two subscales: dizziness/vertigo/anxiety and sensations in the ear. The PSYCHOL scale showed an energy/awareness factor and a negative emotional state factor. The SIT scale, finally, showed two factors: environmental disturbances and stressful conditions. &lt;b&gt;Conclusions: &lt;/b&gt;Knowledge of somatic, psychological and situational premonitory characteristics of attacks in Ménière’s disease could lead to improved therapy and counselling.
Response to Letter Regarding Article, “Long-Term Recording of Cardiac Arrhythmias With an Implantable Cardiac Monitor in Patients With Reduced Ejection Fraction After Acute Myocardial Infarction: The Cardiac Arrhythmias and Risk Stratification After Acute Myocardial Infarction (CARISMA) Study”
Authors: Poul Erik Bloch Thomsen, Christian Jons, Rikke Moerch Joergensen, Uffe Jakob Gang, Heikki V. Huikuri, Hartikainen Juha, Pekka Raatikainen, Vesa Virtanen, J. Boland, Olli Anttonen, Nis Hoest, Lucas V.A. Boersma, Eivin S. Platou, Daniel Becker, Marc D. Messier
Journal: Circulation (2012)

CARISMA) Study"We appreciate the very relevant comments by Ravensbergen and colleagues, and agree that the Cardiac Arrhythmias and Risk Stratification After Acute Myocardial Infarction (CARISMA) Study 1 had several limitations.As we also pointed out, the main limitation, regarding the definition and diagnosis of tachyarrhythmias, was that the rate had to be Ն125 beats per minute for every beat of at least 16 consecutive beats.Thus, tachyarrhythmias of 16 consecutive beats, and with varying R-R intervals longer than 480 ms, could not be recorded by the implantable cardiac monitor (ICM).Another important limitation was the time delay (mean: 11 days) from the acute myocardial infarction to the implantation of the ICM, which may contribute to underreporting of arrhythmias.Despite the limitations, CARISMA was the first study using long-term ECG monitoring in patients surviving an acute myocardial infarction with depressed left ventricular function.The study was only observational, but the results were encouraging.Therefore, we are planning a multinational prospective study in which patients similar to those in the CARISMA Study, but with a few additional risk factors, will be randomized to receive the next generation ICM with 256 Hz resolution before discharge from the hospital versus best medical treatment, to study the possible diagnostic and therapeutical value of the ICM.Hopefully, the newer ICM models will be able to diagnose and store nonsustained irregular ventricular tachycardia lasting less than 16 beats and atrial fibrillation irrespective of ventricular rate, and allow risk assessment by using spectral analysis as well as analysis of heart rate turbulence from the ICM-ECG.
THE EPIDEMIC OF SMALLPOX IN. CUBA.
Authors: R. S. WOODSON
Journal: JAMA (1899)

The present epidemic of smallpox in this Province may be said to be practically at an end. No new cases are appearing; all unprotected persons have been vaccinated, and all infected houses have been disinfected. We have isolated and treated in our isolation hospitals more than twelve hundred cases. These hospitals are located at convenient centers of inspection—Holguin, Gibara, Auras, Fray-Benito, Puerto Padre, Las Nuevas, La Caridad and Mayari, Their records show respectively, 475, 230, 210, 123, 50, 93, 15 and 5 cases. At the present time there are less than three hundred cases under treatment, most of which are convalescent. Our rate of mortality has been less than 12 per cent. We attribute this excellent result to open-air treatment and to bichlorid baths —every patient receiving daily baths in strong solutions (1 to 1000) of bichlorid of mercury. The openair treatment is a necessity in this locality, the open
T cell‐mediated immunoregulation in the gastrointestinal tract
Authors: L. Saurer, C. Mueller
Journal: Allergy (2009)

In the intestinal tract, only a single layer of epithelial cells separates innate and adaptive immune effector cells from a vast amount of antigens. Here, the immune system faces a considerable challenge in tolerating commensal flora and dietary antigens while preventing the dissemination of potential pathogens. Failure to tightly control immune reactions may result in detrimental inflammation. In this respect, 'conventional' regulatory CD4(+) T cells, including naturally occurring and adaptive CD4(+) CD25(+) Foxp3(+) T cells, Th3 and Tr1 cells, have recently been the focus of considerable attention. However, regulatory mechanisms in the intestinal mucosa are highly complex, including adaptations of nonhaematopoietic cells and innate immune cells as well as the presence of unconventional T cells with regulatory properties such as resident TCRgammadelta or TCRalphabeta CD8(+) intraepithelial lymphocytes. This review aims to summarize the currently available knowledge on conventional and unconventional regulatory T cell subsets (Tregs), with special emphasis on clinical data and the potential role or malfunctioning of Tregs in four major human gastrointestinal diseases, i.e. inflammatory bowel diseases, coeliac disease, food allergy and colorectal cancer. We conclude that the clinical data confirms some but not all of the findings derived from experimental animal models.
Individuals, averages, and evidence based medicine
Authors: A. Moore, S. Straube, S. Derry, H. McQuay
Journal: BMJ (2008)

<h3>Objective:</h3> This work aims to investigate the molecular trajectories of different grades of glioma to see how similar they are using a cancer informatics framework. We hypothesize that such a data-driven approach may aid in the discovery of new drug targets and miRNA that can potentially regulate tumor formation, which may benefit treatment and prognosis studies. <h3>Background:</h3> Gliomas are brain tumors that originate in the glial cells. “Glioma” is a blanket term used for defining various kinds of glial tumors, including astrocytoma, oligodendroglioma, and glioblastoma. The aggressiveness or malignancy of gliomas varies. While some are slow-growing and potentially treatable, others are invasive, proliferative, and tend to recur. <h3>Design/Methods:</h3> We have used a translational bioinformatics approach to proceed with the investigation. We used the Disgenet database to retrieve canonical disease gene sets (18 diseases), including three WHO (World Health Organization) grade-wise tumors and eight WHO grade-wise subtypes of Diffuse astrocytic and oligodendroglia tumors, five other astrocytic tumors, and two high and low-grade tumor datasets. <h3>Results:</h3> Enrichr-based pathway enrichment analysis revealed Viral myocarditis, Hepatitis B and C, Malaria, Measles, Influenza, Tuberculosis, and Alcoholism were enriched across different sub-types. STRING-db was used to compute protein networks using graph-based metrics, and critical genes such as LRRC59, CCDC67, TRMT11, and TMEM135 were identified in Glioblastoma multiforme, while Cytoscape was used to prioritize candidates. cBioPortal was used to analyse datasets in order to find racial, gender and age disparities in CNS tumors. <h3>Conclusions:</h3> Further evaluation of these targets could lead to identifying shared and distinct pathways associated with gliomas that could be targeted to develop new treatment approaches. <b>Disclosure:</b> Ms. Kaur has nothing to disclose.
The world inside the head
Authors: Christopher Martyn
Journal: BMJ (2008)

There’s a widespread belief that biology can best be understood at the level of molecular interaction. Although the website of the UK Medical Research Council (MRC) proclaims that it gives a high priority to research that is likely to make a real difference to clinical practice and the health of the population, it spends the lion’s share of its budget on molecular and cellular research. That this is the right thing to do goes virtually unchallenged. Five years ago the House of Commons Science and Technology Committee published a highly critical report of the workings of the MRC, forcing George Radda, then its chief executive, into making the memorable excuse that “with hindsight we should have had more foresight.” But the committee was criticising the way in which the budget was administered rather than how the money was spent.

However, even if we put aside doubts about whether the bodies that fund medical research have achieved the right balance …
Playroom Setting for Diagnostic Family Interviews
Authors: IBRAHIM N. ORGUN
Journal: American Journal of Psychiatry (1973)

The author describes the use of a playroom setting for diagnostic family interviews in which play therapy and family interviewing techniques are incorporated. By using this method the diagnostic team can accumulate valuable diagnostic data on the family, while causing the least discomfort and stress to the children. The method also acquaints the parents with the use of the playroom and play materials in play therapy. After having used this technique for two years, the author believes that it could easily be adapted to family therapy for families with young children.
Neoadjuvant chemoradiotherapy with or without panitumumab in patients with wild-type KRAS, locally advanced rectal cancer (LARC): a randomized, multicenter, phase II trial SAKK 41/07
Authors: D. Helbling, G. Bodoky, O. Gautschi, H. Sun, F. Bosman, B. Gloor, R. Burkhard, R. Winterhalder, A. Madlung, D. Rauch, P. Saletti, L. Widmer, M. Borner, D. Baertschi, P. Yan, J. Benhattar, E.O. Leibundgut, S. Bougel, D. Koeberle
Journal: Annals of Oncology (2012)
DRAINAGE, SEWERAGE AND WATER SUPPLY OF NEW ORLEANS.
Authors: GEORGE G. EARL
Journal: JAMA (1903)

In undertaking to give you a brief account of what has been done, or is contemplated, in the direction of the draining and sewering of New Orleans, as well as in the matter of a water supply for her 300,000 thirsty citizens, I understand that I am undertaking a task which will require a most direct method of treatment, to be kept within bounds as to time, and will, therefore, without circumlocution or delay plunge at once into my subject.  A map of southern Louisiana will show that New Orleans was begotten, geologically, geographically and commercially by the Mississippi river, which, beside being the Father of Waters, and of New Orleans, is the father as well of a very large area of assorted swamps and fertile alluvial lands known as the Mississippi delta.  Just to the north of New Orleans lies Lake Pontchartrain, which is twenty-five miles wide and
Effects of vesnarinone on nitric oxide synthesis in rat cardiac myocytes
Authors: K Kurosaki
Journal: Cardiovascular Research (1998)

Objective: The purpose of this study was to investigate the effects of vesnarinone on nitric oxide (NO) synthesis in cardiac myocytes. Methods: We measured the accumulation of nitrite, a stable oxidation product of NO, and the expression of inducible NO synthase (iNOS) protein in cultured neonatal rat cardiac myocytes. Results: Incubation of the cultures with interleukin-1β (IL-1β; 10 ng/ml) and tumor necrosis factor α (TNFα; 10 ng/ml) caused a marked increase in nitrite production. Although vesnarinone by itself showed no effect on nitrite accumulation, it enhanced cytokine-induced nitrite production by cardiac myocytes in a dose-dependent manner. The effect of vesnarinone was completely abolished in the presence of NG-monomethyl-l-arginine or actinomycin D. The vesnarinone-induced nitrite production was accompanied by increased iNOS protein expression. In the presence of dibutyryl-cAMP, cytokine-induced nitrite accumulation was further increased, but the stimulatory effect of vesnarinone on nitrite accumulation was diminished. The effect of vesnarinone was also inhibited by Rp-8-Br-cAMPS, a competitive inhibitor of protein kinase A, in a dose-dependent manner. Conclusions: These findings indicate that vesnarinone increases NO synthesis in cytokine-stimulated cardiac myocytes, at least partially through a cAMP-dependent pathway.
Emerging role of fibroblast growth factors 15/19 and 21 as metabolic integrators in the liver
Authors: Claudia Cicione, Chiara Degirolamo, Antonio Moschetta
Journal: Hepatology (2012)

Fibroblast growth factors (FGFs) 15/19 and 21 belong to the FGF endocrine subfamily. They present the intriguing characteristic to be transcribed and secreted in certain tissues and to act as hormones. The insulin-mimetic properties of FGF21 and the regulatory role of FGF15/19 in bile acid and glucose homeostasis endorse these hormones as druggable targets in metabolic disorders. Here, we present details on discoveries, identification, transcriptional regulation, and mechanism of actions of FGF15/19 and FGF21 with a critical perspective view on their putative role as metabolic integrators in the liver.
Head injury with unsuspected cervical fracture. A malpractice trap for the unwary physician
Authors: D. S. Rubsamen
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficacy of combination cholestyramine and lovastatin therapy for the treatment of hypercholesterolemia
Authors: Michael H. Davidson, Sherwyn L. Schwartz, Gerald F. Fletcher, Peter O. Kwiterovich, H.Robert Superko, L.Kent Smith, Norman R. Marquis, Jeffrey T. Whitmer, Gary D. Hutton, William S. Mullican
Journal: Journal of the American College of Cardiology (1991)
Medical-Process Patents — Monopolizing the Delivery of Health Care
Authors: Aaron S. Kesselheim, Michelle M. Mello
Journal: New England Journal of Medicine (2006)

Researchers patented their discovery that elevated homocysteine levels are associated with vitamin B12 and folate deficiency. The right to hold a patent on a basic scientific relationship was challenged, and the case (LabCorp v. Metabolite) was appealed to the Supreme Court.
Thrombomodulin Overexpression to Limit Neointima Formation
Authors: J. M. Waugh, J. Li-Hawkins, E. Yuksel, M. D. Kuo, P. N. Cifra, P. R. Hilfiker, R. Geske, M. Chawla, J. Thomas, S. M. Shenaq, M. D. Dake, S. L. C. Woo
Journal: Circulation (2000)

Background —These studies were initiated to confirm that high-level thrombomodulin overexpression is sufficient to limit neointima formation after mechanical overdilation injury. Methods and Results —An adenoviral construct expressing thrombomodulin (Adv/RSV-THM) was created and functionally characterized in vitro and in vivo. The impact of local overexpression of thrombomodulin on neointima formation 28 days after mechanical overdilation injury was evaluated. New Zealand White rabbit common femoral arteries were treated with buffer, viral control, or Adv/RSV-THM and subjected to mechanical overdilation injury. The treated vessels (n=4 per treatment) were harvested after 28 days and evaluated to determine intima-to-media (I/M) ratios. Additional experiments were performed to determine early (7-day) changes in extracellular elastin and collagen content; local macrophage, T-cell, and neutrophil infiltration; and local thrombus formation as potential contributors to the observed impact on 28-day neointima formation. The construct significantly decreased neointima formation after mechanical dilation injury in this model. By histological analysis, buffer controls exhibited mean I/M ratios of 0.76±0.06%, whereas viral controls reached 0.77±0.08%; in contrast, Adv/RSV-THM reduced I/M ratios to 0.47±0.06%. Local inflammatory infiltrate decreased in the Adv/RSV-THM group relative to controls, whereas matrix remained relatively preserved. Rates of early thrombus formation also decreased in Adv/RSV-THM animals. Conclusions —This construct thus offers a viable technique for promoting a locally neointima-resistant small-caliber artery via decreased thrombus bulk, normal matrix preservation, and decreased local inflammation without the inflammatory damage that has limited many other adenoviral applications.
Amoxicillin plus omeprazole versus triple therapy for eradication of Helicobacter pylori in duodenal ulcer disease: a prospective, randomized, and controlled study.
Authors: J Labenz, E Gyenes, G H Ruhl, G Borsch
Journal: Gut (1993)

Treatment with amoxicillin and omeprazole resulted in encouraging Helicobacter pylori eradication rates in pilot studies that included medium term follow up. These results were evaluated in a prospective, randomised and controlled study. Forty patients with active duodenal ulcer disease and H pylori colonisation of the gastric mucosa were randomly assigned to receive either omeprazole (20 mg twice daily) and amoxicillin suspension (500 mg four times daily) for two weeks (group I) or bismuth subsalicylate (600 mg three times daily), metronidazole (400 mg three times daily), tetracycline (500 mg three times daily), and ranitidine (300 mg in the evening) for two weeks (group II). Study medication was followed in both groups by a four week treatment course with 300 mg ranitidine up to the final examination. One patient from each group was lost to follow up. H pylori was eradicated in 78.9% of group I and 84.2% of group II (p = 1.00). All ulcers in patients on omeprazole plus amoxicillin healed but in the triple treatment group four patients had residual peptic lesions after six weeks (ulcer healing rate: 78.9%, p = 0.11). Complete pain relief occurred after a median duration of 1 day in group I and of 6 days in group II (p = 0.03). There were no major complications in either group but minor side effects were more frequently recorded in patients on triple therapy (63.2% v 15.8%, p &lt; 0.01). In conclusion, two weeks of treatment with omeprazole plus amoxicillin is as good as triple therapy plus ranitidine in eradicating H pylori but seems better with regard to safety, pain relief, and ulcer healing. Thus, amoxicillin plus omeprazole should be recommended as the treatment of choice in eradicating H pylori in patients with duodenal ulcer disease.
Radiological appearances in achlorhydria
Authors: B. A. Scobie, G. P. G. Sim
Journal: Gut (1965)

EDITORIAL SYNOPSIS Barium meal findings were correlated with those of gastric biopsy and of histamine tests in 122 patients with various gastrointestinal disorders including pernicious anaemia.The combined radiological features of 'bald fundus' and 'tubular outline' of the stomach were specific for patients with histamine-fast achlorhydria, were observed in eight of 24 instances, and were equally prevalent in achlorhydric patients with and without pernicious anaemia.FIG. 1. Radiographs demonstrating the characteristic features of radiological atrophy and indicative of histamine-fast achlorhydria, namely, 'baldfundus' and 'tubular shape', with loss of the greater curvature folds when distended.137
Work Roles and Responsibilities in Genitourinary Medicine Clinics
Authors: M Fitzgerald
Journal: BMJ (1994)

Isobel Allen, Debra Hogg Policy Studies Institute, £17.95, pp 256 ISBN 0-85374-570-6

Why should non-specialists want to read a book about work roles in genitourinary medicine clinics? The answer relates to the way the genitourinary medicine service has been a precursor of some of the most important recent developments in medical services generally.

In genitourinary medicine customer choice has always been paramount: it is an open access service, and patients themselves decide whether to attend a clinic or see their general practitioner. A particular objective has been to encourage patients with minor symptoms to attend early and so to reduce the rate of onward transmission of infection. In this the clinics have clearly been successful, with around two million patient visits annually and the incidence of gonorrhoea in England one fifth …
Vaginal Curschmann's Spirals
Authors: LEOPOLD G. KOSS
Journal: Annals of Internal Medicine (1974)

Comments and Corrections1 September 1974Vaginal Curschmann's SpiralsLEOPOLD G. KOSS, M.D.LEOPOLD G. KOSS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-3-416_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I can confirm Dr. Prolla's observations (Ann Intern Med 80:674, 1974) that Curschmann's spirals may be occasionally observed in gynecologic smears.The origin of these structures is not completely clear. In at least one such case, which I presented at the International Congress of Cytology in London in May 1971, there was a reasonable suggestion that the Curschmann's spiral found in the vaginal smear, was of extraneous origin: the patient's husband was known to be asthmatic. Smoking by patients probably has nothing to do with the occurrence of these spirals as proposed by Dr. Prolla. The finding... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Pathology Albert Einstein College of Medicine Montefiore Hospital and Medical Center Bronx, New York 10467 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1974Volume 81, Issue 3Page: 416-416KeywordsCell biology Issue Published: 1 September 1974 PDF DownloadLoading ...