Immune-Complex Nephritis in Mixed Connective Tissue Disease
Authors: K. VENKATESWARA RAO
Journal: Annals of Internal Medicine (1976)

Letters1 February 1976Immune-Complex Nephritis in Mixed Connective Tissue DiseaseK. VENKATESWARA RAO, M.B., B.S., ROBERT O. BERKSETH, M.D., JOHN T. CROSSON, M.D., LEOPOLDO RAIJ, M.D., FRED L. SHAPIRO, M.D., F.A.C.P.K. VENKATESWARA RAO, M.B., B.S.Search for more papers by this author, ROBERT O. BERKSETH, M.D.Search for more papers by this author, JOHN T. CROSSON, M.D.Search for more papers by this author, LEOPOLDO RAIJ, M.D.Search for more papers by this author, FRED L. SHAPIRO, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-2-174 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMixed connective tissue disease has been recognized as a rheumatic syndrome with features similar to those of systemic lupus erythematosus, progressive systemic sclerosis, and polymyositis, but distinguished from them by the presence of a specific antibody in high titers to an extractable nuclear antigen (1). Renal involvement was reported to be rare in this disease, and Sharp and colleagues (1) speculated that the antibody to extractable nuclear antigen was exerting protective effect. We describe here a patient with mixed connective tissue disease showing histologic evidence of immune-complex glomerulonephritis in the absence of overt clinical renal disease.An 18-year-old girl noted...References1. SHARPTANGOULD GER: Mixed connective tissue disease—an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). Am J Med 52:148-159, 1972 CrossrefMedlineGoogle Scholar2. WILSONDIXON CF: Diagnosis of immunopathologic renal disease (editorial). Kidney Int 5:389-401, 1974 CrossrefMedlineGoogle Scholar3. KOFFLERAGNELLOTHOBURN DVR: Systemic lupus erythematosus: prototype of immune complex nephritis in man. J Exp Med (suppl) 134:169-179, 1971 CrossrefMedlineGoogle Scholar4. TANNORTHWAYPINNA EJJ: The clinical significance of antinuclear antibodies. Postgrad Med 54:143-150, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Nephrology Department of Medicine Hennepin County Medical Center Department of Medicine University of Minnesota Medical School Minneapolis, Minnesota 55415 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByWidespread vasculopathy with hemolytic uremic syndrome, perimyocarditis and cystic pancreatitis in a young woman with mixed connective tissue diseaseAntinuclear antibodies in scleroderma, mixed connective tissue disease and “primary” Raynaud's phenomenonRenal involvement in mixed connective tissue disease: A longitudinal clinicopathologic studyScleroderma and scleroderma-like disordersCase Report: Non-Hodgkin’s Lymphoma and Membranous Nephropathy in Mixed Connective Tissue DiseaseMixed connective tissue diseaseMixed Connective Tissue DiseaseClinical profiles of patients with antibodies to nuclear ribonucleoproteinPulmonary Hemorrhage and Acute Renal Failure in a Patient With Mixed Connective Tissue DiseaseMIXED CONNECTIVE TISSUE DISEASEIMMUNE COMPLEXES IN THE SERA OF PATIENTS WITH ANTI-RNP ANTIBODIESFaut-il individualiser le syndrome de Sharp (Mixed connective-tissue disease) du lupus érythémateux disséminé ?Mixed connective tissue disease: A clinicopathologic study of 20 casesInterstitial nephritis in a patient with atypical Sj�rgen's syndromeMIXED CONNECTIVE TISSUE DISEASEA histologic evaluation of mixed connective tissue disease in childhoodMixed connective tissue disease with associated glomerulonephritis and hypocomplementaemia.Mischkollagenosen vom Typ des Sharp-Syndroms: Klinische und serologische Befunde sowie differentialdiagnostische AbklärungFatal pulmonary hypertension and resolving immune-complex glomerulonephritis in mixed connective tissue diseaseImmune complex nephropathy in mixed connective tissue diseaseImmune-complex glomerulonephritis in a patient with mixed connective tissue disease 1 February 1976Volume 84, Issue 2Page: 174-175KeywordsAntigensGlomerulonephritisLupus erythematosusMixed connective tissue diseaseNephritisPolymyositisRenal diseasesScleroderma Issue Published: 1 February 1976 PDF DownloadLoading ...