tbuckley/cabot-search huggingface dataset:
Abstract 236: Characterizing cellular signal transduction cross-talk using in-cell kinase screen
Authors: Rajneesh Uzgare, Thomas Hundley, Dhanrajan Tiruchinapalli, Anna Solomon, Cheryl Horton, Hao Chen
Journal: Cancer Research (2012)

Abstract Cancers are known to be heterogeneous diseases. Tumor cell proliferation and the development of metastatic disease involve the activation of multiple, sometime parallel and often compensatory signal transduction pathways. We have developed a cell-based assay platform that measures specific kinase activity within cells, thus allowing us to conduct pathway-based analyses. This platform can be used for 1) discovering new biomarkers and 2) guiding the design of new therapeutic strategies in personalzed medicine, specifically tailored to the patient's genotype. In the present study, we have used this platform to study the impact of G-protein coupled receptor (GPCR) mediation on IGF-1r (RTK) signal transduction cascades in the presence/absence of oestradiol (ER) using MCF-7 breast cancer cells. The results of these studies indicate that mediating neuroendocrine pathways may be an alternative approach that could enhance the efficacies of specific target therapeutics for the treatment of breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 236. doi:1538-7445.AM2012-236
Impact of Lunar Phases on the Occurrance of Acute ST Elevation Myocardial Infarction, Culprit Vessel and Success of Primary Percutaneous Coronary Intervention
Authors: İbrahim Sarı, Hayri Alici, Vedat Davutoglu, Orhan Ozer, Fethi Yavuz, Murat Yuce, Suleyman Ercan, Erdal Durmus, Tarik Kivrak
Journal: Journal of the American College of Cardiology (2013)
Re: Meelan Bul, Xiaoye Zhu, Antti Rannikko, et al. Radical Prostatectomy for Low-Risk Prostate Cancer Following Initial Active Surveillance: Results from a Prospective Observational Study. Eur Urol 2012;62:195–200
Authors: Apostolos P. Labanaris, Vahudin Zugor, Jorn H. Witt
Journal: European Urology (2012)
Characterization of β2-glycoprotein I-dependent and -independent “antiphospholipid” antibodies from lupus-prone NZW/BXSB F1 hybrid male mice
Authors: Perumal Thiagarajan, Anhquyen Le, Sandor S. Shapiro
Journal: American Journal of Hematology (1997)

Male (NZW × BXSB)F1 (W/BF1) mice develop a systemic lupus-like syndrome characterized by thrombocytopenia, coronary vascular disease, nephritis, and anticardiolipin antibodies. Three stable hybridoma cell lines secreting monoclonal anticardiolipin antibodies were developed from these mice by fusing their splenic lymphocytes with nonsecreting myeloma cell line, NS-1. Monoclonal antibody A1.17 reacted with cardiolipin in a β2-Glycoprotein I-dependent manner. The epitope for this antibody consisted of β2-glycoprotein I bound to cardiolipin or immobilized on plastic plates. Other anionic phospholipid-binding proteins, such as prothrombin or annexin V, had no significant effect in the reactivity of these antibodies. The specificity is similar to the autoimmune anticardiolipin antibodies described in patients with systemic lupus erythematosus and other infectious diseases. In contrast, monoclonal antibodies A1.72 and A1.84 reacted with cardiolipin in the absence of β2-glycoprotein I. β2-glycoprotein I, either in the fluid phase or bound to cardiolipin, inhibited the binding of these antibodies. The specificity of the latter two antibodies was similar to that described in patients with syphilis and allied disorders. Both types of antibodies had lupus anticoagulant properties. Thus lupus-prone male (NZW × BXSB)F1 (W/BF1) mice develop both β2-glycoprotein I-dependent and β2-glycoprotein I-independent anticardiolipin antibodies. Am. J. Hematol. 56:86–92, 1997. © 1997 Wiley-Liss, Inc.
P90 Simulated bronchoscopy training delivered by experienced peers improves confidence of new trainees
Authors: A. R. C. Patel, S. Mandal, J. J. P. Goldring
Journal: Thorax (2010)

<h3>Background</h3> Bevacizumab added to carboplatin and paclitaxel is indicated for first-line treatment in advanced non squamous non-small cell lung cancer (NSCLC) and has been associated with improved median overall survival (OS) and progression-free survival (PFS) compared with platinum-based chemotherapy. <h3>Purpose</h3> To determine the demographic characteristics of a group of patients with advanced NSCLC who received carboplatin - paclitaxel - bevacizumab based chemotherapy in our hospital and also to calculate the OS and PFS of these patients. <h3>Materials and methods</h3> Observational retrospective study. Information about patients’ characteristics and their treatment was extracted from a cytostatic prescription program (Oncofarm) and electronic medical history program (Global Clinic). SPSS statistics was used to determinate descriptive characteristics and survival analysis (Kaplan-Meier method). <h3>Results</h3> 33 patients received the treatment from 20/11/2008 to 31/08/2011, men accounted for 66.7% and the median age was 56.4 years. 54.5% of patients had performance status (PS) 1 followed by PS 0 in 18.2% of cases. All patients had stage IV at diagnosis. The most frequent histology was poorly differentiated (11 patients) followed by 10 with adenocarcinoma. 3 patients had squamous cell histology (this treatment is not indicated but compassionate use was granted). In August 2012, 28 of 33 patients suffered disease progression. 22 completed 6 cycles of combined treatment and 15 patients continued with bevacizumab monotherapy. The median OS was 17.0 months (95% CI: 5.3–28.7) and the median PFS was 7.0 months (95% CI: 5.6–8.4). In Sandler’s study,<sup>1</sup> median OS was 12.3 months and median PFS was 6.2 months. <h3>Conclusions</h3> Demographic characteristics of patients, median OS and PFS were similar to published randomised clinical trials, except for histology (adenocarcinoma is not the most frequent type in our observational study). But the observational retrospective design, low number of patients, and dosage differences limited the extrapolation of these results. <h3>Reference</h3> Sandler A, <i>et al</i>. Paclitaxel – carboplatin alone or with bevacizumab for non-small-cell lung cancer. <i>N Engl J Med</i> 2006;355(24):2542-2550 No conflict of interest.
What's the point in restaurant calorie counts?
Authors: E. Davies
Journal: BMJ (2013)

There are a lot of fat people in America. More than a third of US adults are obese according to data from the Centers for Disease Control and Prevention. In 2008, medical costs associated with obesity were estimated at $147bn (£97bn; 113bn); the medical costs for people who are obese were $1429 higher than those of normal weight. Between 1988-94 and 2007-8 the prevalence of obesity increased in adults at all income and education levels. It’s a big problem, no pun intended.

So it’s …
17β-Hydroxysteroid Dehydrogenase Type 1 Is an Independent Prognostic Marker in Breast Cancer
Authors: Olayiwola O. Oduwole, Yan Li, Veli V. Isomaa, Anne Mäntyniemi, Anitta E. Pulkka, Ylermi Soini, Pirkko T. Vihko
Journal: Cancer Research (2004)

Abstract Estrogens have an important role in the development and progression of breast cancer. 17β-Hydroxysteroid dehydrogenase type 1 (17HSD1), type 2 (17HSD2), and type 5 (17HSD5) are associated with sex steroid metabolism in normal and cancerous breast tissue. The mRNA expressions of the 17HSD1, 17HSD2, and 17HSD5 enzymes were analyzed in 794 breast carcinoma specimens by using tissue microarrays and normal histologic sections. The results were correlated with the estrogen receptor α (ER-α) and β (ER-β), progesterone receptor, Ki67, and c-erbB-2 expressions analyzed by immunohistochemical techniques and with the Tumor-Node-Metastasis classification, tumor grade, disease-free interval, and survival of the patients. Signals for 17HSD1 mRNA were detected in 16%, 17HSD2 in 25%, and 17HSD5 in 65% of the breast cancer specimens. No association between the 17HSD1, 17HSD2, and 17HSD5 expressions was detected. A significant association was observed between ER-α and ER-β (P = 0.02; odds ratio, 1.96) expressions. There was also a significant inverse association between ER-α and 17HSD1 (P = 0.04; odds ratio, 0.53), as well as ER-α and 17HSD5 (P = 0.001; odds ratio, 0.35). Patients with tumors expressing 17HSD1 mRNA or protein had significantly shorter overall and disease-free survival than the other patients (P = 0.0010 and 0.0134, log rank). The expression of 17HSD5 was significantly higher in breast tumor specimens than in normal tissue (P = 0.033; odds ratio, 5.56). The group with 17HSD5 overexpression had a worse prognosis than the other patients (P = 0.0146). ER-α also associated with survival (P = 0.045). Cox multivariate analyses showed that 17HSD1 mRNA, tumor size, and ER-α had independent prognostic significance.
Acland’s DVD Atlas of Human Anatomy
Authors: Norm Lieska
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COMPARISON OF CLINICAL OUTCOMES BETWEEN ZOTAROLIMUS- AND SIROLIMUS- ELUTING STENTS IN PATIENTS WITH ST-SEGMENT ELEVATION ACUTE MYOCARDIAL INFARCTION
Authors: Hyun Kuk Kim, Myung Ho Jeong, Youngkeun Ahn, Jong Hyun Kim, Shung Chull Chae, Young Jo Kim, Seung Ho Hur, In Whan Seong, Taek Jong Hong, Dong Hoon Choi, Myeong Chan Cho, Chong Jin Kim, Ki Bae Seung, Yang Soo Jang, Seung Woon Rha, Jang Ho Bae, Jeong Gwan Cho, Seung Jung Park
Journal: Journal of the American College of Cardiology (2010)
The coming of age of sports medicine
Authors: M. E Batt, D. A D Macleod
Journal: BMJ (1997)

Bringing nurses and doctors closer togetherGreater cooperation will benefit patients H igh quality health care depends crucially on doctors and nurses working well together. 1nd every day throughout the world they do.Yet centuries after the professions of nursing and medicine were founded they remain curiously apart. [1]][3] Doctors and nurses train separately, keep separate patient records, 4 report to different hierarchies, read different journals, and use different jargon.Sometimes these differences result in misery and conflict. [1]2][3][4][5][6] The BMJ and the Nursing Standard, for instance, recently described the sad case of a nurse who was suspended after cooperating with a doctor over the management of a disturbed elderly patient. 6 7The professions and, most importantly, patients stand to benefit from closer cooperation, 1 3 8 particularly as nurses take on more work that has traditionally been undertaken by doctors.Nursing is currently experiencing an intense debate over its future. 9Throughout this century first doctors and then strong nursing theorists and leaders have shaped professional and public thinking about nursing.Now nurses agree that the art of nursing needs to be underpinned by a foundation in science.That scientific foundation is being built, and nursing is emerging as a scientific discipline that is distinct from but complementary to medicine.Politicians, however, increasingly see nurses as the lower part of a medical pyramid of knowledge and skills.This is unhelpful and wrong.If we treat nurses as "minidoctors" then patients will lose the enormous benefits that only nurses can offer.There are, of course, important areas of overlap between the professions, and Terence English, a former president of the Royal College of Surgeons, delivered the Dame Kathleen Raven lecture on this subject at the Royal College of Nursing. 10 On page 661 he describes how nurses have taken on some tasks previously done by doctors. 11His experience with the team in Cambridge performing heart transplantation taught him how important it is for nurses, doctors, and other health professionals to work still more closely together.But it also taught him the difficulties.He warns that "unless there is dialogue and trust between the groups, one or more of them are likely to feel threatened as their roles are changed."One way in which doctors and nurses will come to understand each other is through receiving some of their training together and understanding more of each others' roles from the start of professional training.On page 682 two medical students describe how much they learnt from a week working as nurses. 12
Primary Dissecting Aneurysm of Coronary Artery
Authors: DAVID G. CLAUDON, DANN B. CLAUDON, JESSE E. EDWARDS
Journal: Circulation (1972)

Primary dissecting aneurysm of a coronary artery is a rare form of acute coronary arterial obstruction. A review of 24 cases, including two observed by the authors, indicates that this condition tends to occur (1) in the young adult, (2) in the female more commonly than the male, and (3) relatively commonly in the postpartum state. The clinical manifestations take the form either of sudden death or acute myocardial infarction. In the latter situation, there is the potential for overcoming the coronary arterial obstruction by a surgical bypass procedure.
63 CHARACTERIZATION OF VIROLOGIC ESCAPE IN HCV GENOTYPE 1 NULL RESPONDERS RECEIVING A COMBINATION OF THE NS3 PROTEASE INHIBITOR BMS-650032 AND NS5A INHIBITOR BMS-790052
Authors: F. McPhee, D. Hernandez, F. Yu, J. Ueland, C. Wang, H. Huang, D. Gardiner, R. Fridell, M. Gao
Journal: Journal of Hepatology (2011)
Quantitative analysis of pre-S1 and pre-S2 in relation to HBsAg expression
Authors: Nobukazu Yuki, Norio Hayashi, Kazuhiro Katayama, Akinori Kasahara, Keiji Ueda, Hideyuki Fusamoto, Nobuhiro Sato, Takenobu Kamada
Journal: Hepatology (1990)

Sera from four patients with acute hepatitis B and 87 patients with chronic hepatitis B were examined quantitatively for pre–S1 and pre–S2 antigens by solid–phase enzyme immunoassays. Pre–S1 and pre–S2 antigens were detected in HBsAg–positive sera irrespective of the presence of viral replicative markers, and their titers correlated with those of HbsAg(r = 0.74, p &lt; 0.01; r = 0.74, p &lt; 0.01, respectively). Sera positive for HBeAg showed higher titers of pre–S1 (p &lt; 0.01) and pre–S2 (p &lt; 0.01) antigens than sera negative for HBeAg. The titers of pre–S1 and pre–S2 antigens also correlated with the levels of HBV–associated DNA polymerase activity (r = 0.51, p &lt; 0.01; r = 0.59, p &lt; 0.01, respectively) and HBV–DNA (r = 0.50, p &lt; 0.01; r = 0.46, p &lt; 0.01, respectively). However, the ratios between the titers of pre–S antigens and HBsAg had no significant relationships with those viral replicative markers. These findings suggest that the expression of pre–S antigens is intimately related to the expression of HBsAg and that they are not useful as markers of viral replication. The ratios between the titers of pre–S antigens and HBsAg tended to be high in patients with chronic active hepatitis and high aminotransferase levels. This finding may have been due to the hepatic release of pre–S antigens, overproduction of which may have some relationship to liver injury.
Evaluation of serum cystatin C concentration as a marker of renal function in patients with cirrhosis of the liver
Authors: A L Gerbes
Journal: Gut (2002)

Background and aims: Diagnosis of moderately impaired renal function is of particular importance in patients with cirrhosis of the liver. Whereas patients with a markedly impaired glomerular filtration rate can be diagnosed easily by elevated serum creatinine concentrations, moderately reduced renal function may be missed by this conventional parameter. Recently, cystatin C has been suggested as a sensitive marker of renal function, independent of sex or muscle mass. Therefore, the aim of this study was to investigate the value of serum cystatin C concentration for the detection of moderately impaired renal function. Methods: Ninety seven inhospital patients with cirrhosis and a 24 hour creatinine clearance of at least 40 ml/min were investigated and divided into group 1 (creatinine clearance ≥70 ml/min; n=55) and group 2 (creatinine clearance 40–69 ml/min; n=42). Results: Serum cystatin C concentrations (mean (SD): 1.31 (0.51) <i>v</i> 1.04 (0.34) mg/l (p=0.008)) and creatinine concentrations (1.03 (0.52) <i>v</i> 0.86 (0.22) mg/100 ml (p=0.03)) were higher in group 2 than in group 1; there was no significant difference in urea concentrations. Receiver-operator characteristics (ROC) revealed a differential diagnostic advantage of cystatin C over creatinine and urea. At cut off concentrations of 1.0 mg/l, 0.9 mg/100 ml, and 28 mg/100 ml, respectively, cystatin C, creatinine, and urea exhibited 69%, 45%, and 44% sensitivity (p&lt;0.05). As patients with a small muscle mass or reduced physical activity could be particularly prone to overestimation of their renal function, separate analyses were performed for the subgroups of female and Child-Pugh class C patients, respectively. In both groups, discrimination between patients with moderately impaired and normal renal function was best with cystatin C. In female patients, sensitivity of cystatin C (77.8%) was superior (p&lt;0.05) to that of creatinine (38.9%) and urea (41.2%). In Child-Pugh C patients, the ROC curve was significantly better for cystatin C than for creatinine. Conclusions: Serum cystatin C determination could be a valuable tool in patients with cirrhosis, particularly with Child-Pugh class C or in female patients, for early diagnosis of moderately impaired renal function.
Setting priorities: is there a role for citizens' juries?
Authors: J. Lenaghan, B. New, E. Mitchell
Journal: BMJ (1996)

Citizens' juries are an attempt to meaningfully involve members of the public in decisions which affect them in their own communities. The Institute for Public Policy Research and Cambridge and Huntingdon Health Authority have recently piloted the first jury in the United Kingdom. Sixteen jurors sat for four days, hearing evidence from a number of expert witnesses. The jurors were asked to consider how priorities for health care should be set, according to what criteria, and to what extent the public should be involved in this process. This pilot was also an attempt to assess the process itself, and our initial evaluation indicates that, given enough time and information, the public is willing and able to contribute to the debate about priority setting in health care.
Lidocaine Pharmacokinetics in Advanced Heart Failure, Liver Disease, and Renal Failure in Humans
Authors: PATE D. THOMSON
Journal: Annals of Internal Medicine (1973)

The pharmacokinetics of intravenously administered lidocaine were studied in 10 normal subjects, 11 patients with heart failure, 8 patients with alcoholic liver disease, and 6 chronic renal dialysis patients. In heart failure subjects, both the measured volume of distribution and plasma clearance were significantly reduced. Liver disease subjects showed a reduced plasma clearance and prolongation of the "dominant phase" half-life. Neither volume of distribution nor clearance was abnormal in renal disease subjects. The alterations in volume of distribution and clearance are related to the activity of the circulation in drug disposition. The low clearance implies the need to decrease dosage regimens or alter infusion rates in patients with advanced heart failure or liver disease.
Porto-pulmonary hypertension exacerbated by platelet transfusion in a patient with ADAMTS13 deficiency
Authors: Joshua E. Elias, Ian Mackie, Chundamannil E. Eapen, Patrick Chu, Jean C. Shaw, Elwyn Elias
Journal: Journal of Hepatology (2012)

We propose that porto-pulmonary hypertension (PPH) may arise as a consequence of deficiency of ADAMTS13 (a plasma metalloprotease that regulates von Willebrand factor size and reduces its platelet adhesive activity) and provide a clinical case history to support our hypothesis.A patient with non-cirrhotic intrahepatic portal hypertension (NCIPH), ulcerative colitis and celiac disease developed symptoms of PPH, which had advanced beyond levels which would have made her an eligible candidate for liver transplantation (mean pulmonary artery pressure (PAP) 49 mmHg). She was known to have severe ADAMTS13 deficiency, which we considered to be causative of, or contributory to her NCIPH. We postulated that increasing porto-systemic shunting associated with advancing portal hypertension would make the next encountered vascular bed, the lung, susceptible to the pathogenic process that was previously confined to the portal system, with pulmonary hypertension as its consequence. Her pulmonary artery pressures fell significantly during the next year on weekly replacement of plasma ADAMTS13 by infusions of fresh frozen plasma and conventional drug treatment of her pulmonary hypertension. Her pulmonary artery pressures had fallen to acceptable levels when, in response to platelet infusion, it rose precipitously and dangerously.The sequence strongly supports our hypothesis that PPH is a consequence of ADAMTS13 deficiency and is caused by platelet deposition in afferent pulmonary vessels.
Recruitment, retention, and compliance results from a probability study of children's environmental health in economically disadvantaged neighborhoods.
Authors: Ken Sexton, John L Adgate, Timothy R Church, Ian A Greaves, Gurumurthy Ramachandran, Ann L Fredrickson, Mindy S Geisser, Andrew D Ryan
Journal: Environmental Health Perspectives (2003)

The School Health Initiative: Environment, Learning, and Disease (SHIELD) study used a probability sample of children (second through fifth grades) from two low-income and racially mixed neighborhoods of Minneapolis, Minnesota, to assess childhood environmental health. Children were eligible to participate in SHIELD regardless of whether they or their families spoke a foreign language, their household had a telephone, or they were enrolled in a special education program. The overall enrollment rate in year 1 was 57%, with a substantial disparity between children from English-speaking (42%) versus non-English-speaking (71%) families. At the end of year 1, 85% were retained in the study. A relatively high percentage of children provided the two requested blood (82%) and urine (86%) samples in year 1, and 90% provided a valid spirometry sample. Eighty-two percent provided both requested volatile organic chemical badge samples, and both time-activity logs were obtained from 66%. However, only 32% provided both peak flow measurements. All percentages increased for those participating in the second year of the study. Results indicate that a school-based research design makes it feasible and practical to conduct probability-based assessments of children's environmental health in economically disadvantaged and ethnically diverse neighborhoods. There is an ongoing need, however, to improve understanding of the cultural, economic, psychologic, and social determinants of study participation among this population.