Rhabdomyolysis with Cardiac Involvement and Acute Renal Failure in a Patient Taking Rosuvastatin and Fenofibrate
Authors: James H.E. Ireland, Christoph H. Eggert, Christopher J. Arendt, Amy W. Williams
Journal: Annals of Internal Medicine (2005)

Letters7 June 2005Rhabdomyolysis with Cardiac Involvement and Acute Renal Failure in a Patient Taking Rosuvastatin and FenofibrateJames H.E. Ireland, MD, Christoph H. Eggert, MD, Christopher J. Arendt, PharmD, and Amy W. Williams, MDJames H.E. Ireland, MDFrom Mayo Clinic College of Medicine, Rochester, MN 55905.Search for more papers by this author, Christoph H. Eggert, MDFrom Mayo Clinic College of Medicine, Rochester, MN 55905.Search for more papers by this author, Christopher J. Arendt, PharmDFrom Mayo Clinic College of Medicine, Rochester, MN 55905.Search for more papers by this author, and Amy W. Williams, MDFrom Mayo Clinic College of Medicine, Rochester, MN 55905.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-11-200506070-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, have revolutionized therapy for hypercholesterolemia. Although uncommon, statin-induced myopathy is a well-described side effect (1). A new statin, rosuvastatin, has been particularly scrutinized because rhabdomyolysis and renal failure occurred in early trials (2). We report on a patient who developed rhabdomyolysis with cardiac involvement and renal failure while taking rosuvastatin.Case Report: A 67-year-old woman with no history of renal disease was referred with chest pain from an outside institution. She had a history of hypertension, chronic back pain, and hypercholesterolemia and was taking hydrochlorothiazide–olmesartan and oxaprozin. She ...Reference1. Thompson PD, Clarkson P, Karas RH. Statin-associated myopathy. JAMA. 2003;289:1681-90. [PMID: 12672737] CrossrefMedlineGoogle Scholar2. Wolfe SM. Dangers of rosuvastatin identified before and after FDA approval [Letter]. Lancet. 2004;363:2189-90. [PMID: 15220045] CrossrefMedlineGoogle Scholar3. Bybee KA, Kara T, Prasad A, Lerman A, Barsness GW, Wright RS, et al. Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction. Ann Intern Med. 2004;141:858-65. [PMID: 15583228] LinkGoogle Scholar4. Stelow EB, Johari VP, Smith SA, Crosson JT, Apple FS. Propofol-associated rhabdomyolysis with cardiac involvement in adults: chemical and anatomic findings. Clin Chem. 2000;46:577-81. [PMID: 10759487] CrossrefMedlineGoogle Scholar5. Punukollu G, Gowda RM, Khan IA, Mehta NJ, Navarro V, Vasavada BC, et al. Elevated serum cardiac troponin I in rhabdomyolysis. Int J Cardiol. 2004;96:35-40. [PMID: 15203259] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Mayo Clinic College of Medicine, Rochester, MN 55905.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSystematic Review: Transient Left Ventricular Apical Ballooning: A Syndrome That Mimics ST-Segment Elevation Myocardial Infarction Kevin A. Bybee , Tomas Kara , Abhiram Prasad , Amir Lerman , Greg W. Barsness , R. Scott Wright , and Charanjit S. Rihal Metrics Cited ByDrugs for the SkinternistTransient Left Ventricular Contractile Dysfunction during the Treatment of Rhabdomyolysis: A Case Report and Literature ReviewTakotsubo Cardiomyopathy with Involvement of Delayed-onset Rhabdomyolysis and Acute Kidney Injury after Rosuvastatin TreatmentStatin-Associated Rhabdomyolysis With Acute Renal Failure Complicated by Intradialytic NSTEMIFenofibrate-induced rhabdomyolysis in a patient with chronic renal failure due to nephrotic syndrome: A rare case reportSafety review of combination drugs for hyperlipidemiaAcute renal failure with the combined use of rosuvastatin and fenofibrateRosuvastatin-Associated Adverse Effects and Drug-Drug Interactions in the Clinical Setting of DyslipidemiaRhabdomyolysis associated with fibrate therapy: review of 76 published cases and a new case reportRosuvastatin-induced Rhabdomyolysis Probably via CYP2C9 SaturationFenofibrate-Induced Acute Renal Failure Due to Massive Rhabdomyolysis after Coadministration of Statin in Two PatientsFenofibrateNéphrotoxicité des médicaments: veille bibliographique janvier 2003–décembre 2005Clinical Perspectives of Statin-Induced Rhabdomyolysis 7 June 2005Volume 142, Issue 11Page: 949-950KeywordsEjection fractionHeart diseasesIschemiaProteinuriaRenal failureResearch laboratoriesRhabdomyolysisStable coronary artery diseaseStatinsToxicity ePublished: 7 June 2005 Issue Published: 7 June 2005 CopyrightCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...