tbuckley/cabot-search huggingface dataset:
Chronic antisense therapy for angiotensinogen on cardiac hypertrophy in spontaneously hypertensive rats
Authors: N Makino
Journal: Cardiovascular Research (1999)

Objective: We examined the effect of the suppression of plasma angiotensinogen (AGT) by the intravenous injection of antisense oligodeoxynucleotides (ODNs) against AGT targeted to the liver on cardiac remodeling in spontaneously hypertensive rats (SHR). The ODNs against rat AGT were coupled to asialoglycoprotein (ASOR) carrier molecules, which serve as an important method for regulating liver gene expression. Methods: Male SHR (n=18), and age-matched male Wistar–Kyoto rats (WKY, n=6) were used for this study. At 10 weeks of age, the SHR were divided into three groups (each group n=6), and the systolic blood pressure (SBP) did not significantly change among them. The control SHR and WKY groups received saline, the sense SHR group was injected with the sense ODNs complex and the antisense SHR group was injected with the antisense ODNs complex, from 10 to 20 weeks of age. ASOR–poly(l)lysine–ODNs complex was injected via the tail veins twice a week. Results: At the end of the treatment, a reduction of hepatic AGT mRNA, cardiac angiotensin II type 1 receptor mRNA and the plasma AGT concentration was only observed in the antisense-injected SHR but not in the other groups of SHR and WKY. This antisense therapy did not significantly change the mRNA expression for angiotensin converting enzyme, angiotensin II type 2 receptor and AGT in the left ventricle (LV) among all three groups. Although the plasma angiotensin II (Ang II) concentration significantly decreased to the level of WKY after the antisense therapy, the SBP, LV to body weight ratio and % collagen volume fraction also showed a reduction, however, these findings were still larger than in the WKY than in either the sense-injected SHR or control SHR. Conclusion: The plasma AGT is considered to play a role in the development of cardiac hypertrophy in SHR, but it has not a complete effects on cardiac remodeling even if the plasma Ang II levels are inhibited because of an insufficient suppression of hypertension.
Driving Mishaps Among Individuals With Type 1 Diabetes
Authors: Daniel J. Cox, Derek Ford, Linda Gonder-Frederick, William Clarke, Roger Mazze, Katie Weinger, Lee Ritterband
Journal: Diabetes Care (2009)

OBJECTIVE Hypoglycemia-related neuroglycopenia disrupts cognitive-motor functioning, which can impact driving safety. Retrospective studies suggest that drivers with type 1 diabetes experience more collisions and citations than their nondiabetic spouses. We present the first prospective data documenting the occurrence of apparent neuroglycopenia-related driving performance impairments. RESEARCH DESIGN AND METHODS We completed the initial screening of 452 drivers from three geographically diverse centers who then reported monthly occurrences of driving “mishaps,” including collisions, citations, losing control, automatic driving, someone else taking over driving, and moderate or severe hypoglycemia while driving. RESULTS Over 12 months, 52% of the drivers reported at least one hypoglycemia-related driving mishap and 5% reported six or more. These mishaps were related to mileage driven, history of severe hypoglycemia, and use of insulin pump therapy. CONCLUSIONS Many individuals with type 1 diabetes report hypoglycemia-related driving events. Clinicians should explore the recent experiences with hypoglycemia while driving and the risk of future events.
Melanoma BRAF Fusions—Response
Authors: Katherine E. Hutchinson, Jeffrey S. Ross, Philip J. Stephens, Vincent A. Miller, Jeffrey A. Sosman, William Pao
Journal: Clinical Cancer Research (2014)

We appreciate the comments from Dr. Botton and colleagues (1) regarding our article entitled “BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition” (2). In response to their letter, we make the following points: We again thank Botton and colleagues (1) for highlighting the association of BRAF fusions with Spitzoid morphology in metastatic melanomas. This information should inform clinical decision-making in the treatment of patients with melanoma.See the original Letter to the Editor, p. 6631J.S. Ross, P.J. Stephens, and V.A. Miller are employees of and have ownership interests (including patents) in Foundation Medicine. No potential conflicts of interest were disclosed by the other authors.Financial support was provided by the James C. Bradford Family Foundation (VICC investigators), the Mary Hendrickson-Johnson American Cancer Society Melanoma Professorship (J.A. Sosman), the NIH/National Cancer Institute 5K24 CA097588-09 (J.A. Sosman), a Stand Up To Cancer Innovative Research Grant (grant number SU2C-AACR-IRG0109, to W. Pao; Stand Up To Cancer is a Program of the Entertainment Industry Foundation administered by the American Association for Cancer Research), and the Joanna M. Nicolay Melanoma Foundation 2013 Research Scholar Award (K.E. Hutchinson).
Ultrahigh-Resolution Optical Coherence Tomography in Patients with Decreased Visual Acuity after Retinal Detachment Repair
Authors: Lisa S. Schocket, Andre J. Witkin, James G. Fujimoto, Tony H. Ko, Joel S. Schuman, Adam H. Rogers, Caroline Baumal, Elias Reichel, Jay S. Duker
Journal: Ophthalmology (2006)
Abstract C23: Therapy of triple-negative breast tumors by targeting the MYC oncogene pathway
Authors: Dai Horiuchi, Leonard Kusdra, Molly Klein-McDowell, Katelyn J. Creasman, Andrei Goga
Journal: Cancer Research (2009)

Abstract Human breast cancers that lack expression of the estrogen and progesterone nuclear receptors and with low HER2 expression are known as “gtriple-negative” tumors. These are amongst the most aggressive breast cancers and no targeted therapeutics exists for this subclass of human tumors. MYC is a proto-oncogene transcription factor that plays a key role in cell cycle transition of mammalian cells. Increased expression of MYC is estimated to occur in ∼ 20–50% of human breast cancers. Genomic amplification of the MYC locus, 8q24, is correlated with decreased patient survival, and MYC-over-expression in breast cancer cells has been associated with a resistance to anti-hormonal therapies that seek to inhibit ER signaling. Furthermore, MYC has recently been shown to be one of the genes unique to high-grade mammary tumors. Thus, these prior studies suggest that the level of MYC expression might be useful as a biomarker and that the inhibition of MYC function may be a useful therapeutic approach against this difficult-to-treat type of breast cancer. However, while MYC is strongly implicated in breast tumorigenesis, no direct small molecule inhibitors of its transcriptional activity are available in clinical practice. An alternative approach to directly inhibiting MYC is to find “synthetic-lethal” combinations that selectively kill those cells with elevated MYC levels without affecting normal cells. The term “synthetic-lethality” refers to a genetic context in which a mutation in a gene, which itself does not cause lethality, can cause lethality when combined with a mutation in another gene. Using engineered cells, we have previously demonstrated that inhibiting cyclin-dependent kinase 1 (CDK1) can kill cells that over-express MYC. We have now used a panel of breast cancer cell lines established from human patients to show that (1) those breast cancers that are receptor-negative have significantly higher levels of MYC protein, (2) that the MYC pathways are critical for the survival and proliferation of this tumor subset, (3) CDK1 inhibition in triple-negative breast cancer cells results in the initiation of apoptosis mediated by mitochondria-dependent intrinsic pathway, and that (4) this apoptotic event is specifically achieved by altering the balance between pro-survival and pro-apoptotic members of the Bcl-2 family proteins. Our results present a novel treatment strategy for “triple-negative” breast cancers by targeting the MYC pathways via CDK inhibitors. Citation Information: Cancer Res 2009;69(23 Suppl):C23.
Psychiatric Symptoms Common in Neurological Disorders
Authors: Lynne Lamberg
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RT-PCR and FISH analysis of acute myeloid leukemia with t(8;16)(p11;p13) and chimeric MOZ and CBP transcripts: breakpoint cluster region and clinical implications
Authors: H H Schmidt, S Strehl, D Thaler, D Strunk, H Sill, W Linkesch, U Jäger, W Sperr, H T Greinix, M König, W Emberger, O A Haas
Journal: Leukemia (2004)
Prevalence of Arsenic Exposure from Drinking Water and Awareness of Its Health Risks in a Bangladeshi Population: Results from a Large Population-Based Study
Authors: Faruque Parvez, Yu Chen, Maria Argos, A.Z.M. Iftikhar Hussain, Hassina Momotaj, Ratan Dhar, Alexander van Geen, Joseph H. Graziano, Habibul Ahsan
Journal: Environmental Health Perspectives (2005)

We conducted a population-based prevalence survey in Araihazar, Bangladesh, to describe the distribution of arsenic exposure in a rural Bangladeshi population and to assess the population’s awareness to this problem as well as to possible remediation options. Water samples from 5,967 contiguous tube wells in a defined geographic area were tested using laboratory-based methods. Additionally, for each well, the owner/caretaker (or a close relative) was interviewed regarding his or her awareness of the health consequences of As exposure. Arsenic exposure data and demographic characteristics for the 65,876 users of these wells were also collected from the 5,967 respondents. Among the 65,876 residents, more than half (54%) regularly consumed well water with an As concentration ≥ 50 μg/L—above the acceptable government standard in Bangladesh. Respondents were 15–92 years of age, with an average age of 42 years, and 43% were male. Presence of awareness was significantly related to male sex, nonlabor head of household occupation, better housing, and having had the well tested for As concentration. Most respondents (92%) expressed a willingness to take steps to reduce their exposure, with switching to a safe well the most favored option (46.2%). Willingness to reduce exposure was positively related to awareness of the health risks of As. However, the association between awareness and switching to a safe well [odds ratio (OR) = 1.25; 95% confidence interval (CI), 1.01–1.54] was no stronger than the associations between awareness and using surface water (with or without treatments) (OR = 1.54; 95% CI, 1.22–1.95) or using an existing well after treatment or increasing the depth (OR = 1.34; 95% CI, 1.08–1.67). These findings suggest that health education programs may need to target individuals with lower socioeconomic status and that well switching should be encouraged with more appropriate health education. Increasing knowledge of the health consequences of As may be an important element in facilitating remediation.
Rectal route in the 21st Century to treat children
Authors: Vincent Jannin, Gilles Lemagnen, Pascale Gueroult, Denis Larrouture, Catherine Tuleu
Journal: Advanced Drug Delivery Reviews (2014)

The rectal route can be considered a good alternative to the oral route for the paediatric population because these dosage forms are neither to be swallowed nor need to be taste-masked. Rectal forms can also be administered in an emergency to unconscious or vomiting children. Their manufacturing cost is low with excipients generally regarded as safe. Some new formulation strategies, including mucoadhesive gels and suppositories, were introduced to increase patient acceptability. Even if recent paediatric clinical studies have demonstrated the equivalence of the rectal route with others, in order to enable the use of this promising route for the treatment of children in the 21st Century, some effort should be focused on informing and educating parents and care givers. This review is the first ever to address all the aforementioned items, and to list all drugs used in paediatric rectal forms in literature and marketed products in developed countries.
Multicenter European External Validation of a Prostate Health Index–based Nomogram for Predicting Prostate Cancer at Extended Biopsy
Authors: Giovanni Lughezzani, Massimo Lazzeri, Alexander Haese, Thomas McNicholas, Alexandre de la Taille, Nicolò Maria Buffi, Nicola Fossati, Giuliana Lista, Alessandro Larcher, Alberto Abrate, Alessandro Mistretta, Vittorio Bini, Joan Palou Redorta, Markus Graefen, Giorgio Guazzoni
Journal: European Urology (2013)
18F-FDG PET/CT Findings in a Patient With a Proliferating Trichilemmal Cyst
Authors: Pierre Leyendecker, Ghislaine de Cambourg, Antoine Mahé, Alessio Imperiale, Cyrille Blondet
Journal: Clinical Nuclear Medicine (2015)

Proliferating trichilemmal cyst is considered as a rare tumor that originates in the outer root sheath of hair follicle. Metastatic potential has not been yet fully established. Moreover, histological analysis does not allow precise malignancy prediction. Proliferating trichilemmal cyst glucose metabolism behavior was never previously described. Herein, we report the case of a 62-year-old patient with a left shoulder proliferating trichilemmal cyst showing an intense uptake of ¹⁸F-FDG on PET/CT examination. ¹⁸F-FDG PET/CT could be proposed to optimize diagnostic strategy of patients with proliferating trichilemmal cysts.
Why Not Start With Thalidomide?
Authors: Charles Loprinzi, S. Vincent Rajkumar
Journal: Journal of Clinical Oncology (2003)

Article Tools ART OF ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.03.113 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12775748 Why Not Start With Thalidomide? Charles LoprinzixCharles LoprinziSearch for articles by this author , S. Vincent RajkumarxS. Vincent RajkumarSearch for articles by this author Show More From the Mayo Clinic, Rochester, MN. https://doi.org/10.1200/JCO.2003.03.113 First Page Full Text PDF Figures and Tables © 2003 by American Society of Clinical Oncology
Abstract 4921: A new method for identifying a data-consistent self-reconfigurable predictive bio-network model of the cell cycle based on time series data and its application in cancer systems biology
Authors: Michael A. Idowu, James Bown, Nikolai Zhelev
Journal: Cancer Research (2012)

Abstract A new method for (re)constructing interaction networks using a limited number of time series data has been developed. This method may provide better opportunities for immediate identification of data-consistent models of biological systems. It may serve as an alternative or complementary approach to other existing data-driven strategies for modeling or mining time-evolutionary properties of complex biological processes based on the analysis of their time series data. We present some practically useful data-mining techniques for constructing self-reconfigurable predictive models of complex biological systems, which approximate their underlying processes. These parametric models, if well reverse-engineered, may help capture key features of data relevant for the purpose of interest. To demonstrate our network inference method, we focus on analyzing time series data of cdk2, cyclinA1, cyclinD1, cycinD2, cyclinD3, E2F1, p16 and p27 obtained from real experiments. The constructed predictive model of the cell-cycle is found to be data-consistent. This model approximates the underlying biological processes hidden in the data, and may help reveal or identify key processes that may govern G1-S phase progression. Given multiple sets of time series data from a cell line, where some sets represent control conditions and other intervention conditions, the method introduced here can help construct interaction networks for each of these data sets. To investigate areas of the signaling network most affected by the intervention, critical areas that have been identified in those networks could be compared to the effects of real perturbations. This may help inform future experimental design by targeting sensitive areas in the signaling network or avoiding resistant pathways. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4921. doi:1538-7445.AM2012-4921
The third generation oral contraceptive controversy
Authors: P. A O'Brien
Journal: BMJ (1999)

Papers p 820 

New evidence on myocardial infarction and the recent statement from the Medicines Commission giving a greater role to clinical judgment in choosing a contraceptive pill1 call for a reassessment of the role of third generation oral contraceptives containing desogestrel or gestodene. The shift to third generation pills in the early 1990s was largely based on claims of superior cardiovascular safety. We now have evidence on which to assess these claims

A lower risk of myocardial infarction in users of third compared with users of second generation pills was found in the Transnational study, although not in the British subgroup or in women aged under 35.2 However, the results did not take account of product specific differences in screening for hypertension before women started using the pill, which had a large effect in users of second generation pills (MA Lewis, personal communication). A similar influence had previously been found in the World Health Organisation study: in women whose blood pressure had been checked, the difference between the pill generations disappeared.3 It seems that undiagnosed hypertension was more common in second generation users …
Case 19-1973
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, Lot B. Page, Sanford I. Roth
Journal: New England Journal of Medicine (1973)

Presentation of CaseA 13-year-old girl was admitted to the hospital because of hypertension.Five years previously enuresis developed, and she began to complain of frontal headaches. A physician found that her blood pressure was 180/110. Four years before admission an intravenous pyelographic examination (Fig. 1) revealed that the right kidney was smaller than the left. The patient was referred to this hospital. On examination the pulse was 130, and the blood pressure 160/110. A Grade 2 systolic ejection murmur was heard along the left sternal border. The abdomen was normal. The peripheral pulses were graded + +, were symmetrical . . .
Membrane distribution of sodium-hydrogen and chloride-bicarbonate exchangers in crypt and villus cell membranes from rabbit ileum.
Authors: R G Knickelbein, P S Aronson, J W Dobbins
Journal: Journal of Clinical Investigation (1988)

Present evidence suggests that in the small intestine, villus cells are primarily absorptive and crypt cells are primarily secretory. In order to further confirm that there are differences in transport properties between villus and crypt cells, we have separated villus from crypt cells, using calcium chelations techniques, and determined the distribution of Na:H and Cl:HCO3 exchange activity on brush border membrane and basolateral membrane preparations from these two cell populations. Separation of cells was determined utilizing alkaline phosphatase and maltase activity as a marker of villus cells and thymidine kinase activity as a marker of crypt cells. Utilizing these techniques, we were able to sequentially collect cells along the villus-crypt axis. Na-stimulated glucose and alanine uptake in brush border membrane vesicles diminished from the villus to the crypt region in the sequentially collected cells fractions, further suggesting separation of these cells. Brush border and basolateral membranes were then prepared from cells from the villus and crypt areas, utilizing a continuous sucrose gradient. In the villus cells, Na:H exchange activity was found associated with both the brush border and basolateral membrane, whereas, in crypt cells, Na:H exchange activity was only found on the basolateral membrane. Cl:HCO3 exchange activity was found only on the brush border membrane, in both villus and crypt cells. These studies suggest functional heterogeneity in ion transport between villus and crypt cells.
An unusual case of acquired localized argyria
Authors: L. SHALL, A. STEVENS, L.G. MILLARD
Journal: British Journal of Dermatology (1990)

Journal Article An unusual case of acquired localized argyria Get access L. SHALL, L. SHALL Department of Dermatology, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, U.K. Dr L. Shall. Search for other works by this author on: Oxford Academic Google Scholar A. STEVENS, A. STEVENS Department of, Histopathology, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, U.K. Search for other works by this author on: Oxford Academic Google Scholar L.G. MILLARD L.G. MILLARD Department of Dermatology, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 123, Issue 3, 1 September 1990, Pages 403–407, https://doi.org/10.1111/j.1365-2133.1990.tb06302.x Published: 01 September 1990
Spontaneous pneumothorax in a patient with an azygos lobe
Authors: R. T. Sadikot, M. E. Cowen, A. G. Arnold
Journal: Thorax (1997)

The association between a spontaneous pneumothorax and an azygos lobe is surprisingly rare. A case is reported in which surgical management was difficult; it is suggested that thoracotomy is preferable to video-assisted thoracoscopic surgery in this situation. It is possible that the presence of an azygos lobe might protect against the subsequent development of a spontaneous pneumothorax, and the possible mechanism of this is discussed.