tbuckley/cabot-search huggingface dataset:
Treatment of hidradenitis suppurativa with intralesional photodynamic therapy using a laser diode attached to an optical cable: a promising new approach
Authors: L.M. Valladares-Narganes, M.A. Rodríguez-Prieto, M.D. Blanco-Suárez, C. Rodriguez-Lage, I. García-Doval
Journal: British Journal of Dermatology (2014)

Journal Article Treatment of hidradenitis suppurativa with intralesional photodynamic therapy using a laser diode attached to an optical cable: a promising new approach Get access L.M. Valladares‐Narganes, L.M. Valladares‐Narganes Department of Dermatology Complejo Asistencial Universitario de León Calle Altos de Nava s/n León León 24003 Spain Search for other works by this author on: Oxford Academic Google Scholar M.A. Rodríguez‐Prieto, M.A. Rodríguez‐Prieto Department of Dermatology Complejo Asistencial Universitario de León Calle Altos de Nava s/n León León 24003 Spain Search for other works by this author on: Oxford Academic Google Scholar M.D. Blanco‐Suárez, M.D. Blanco‐Suárez Department of Dermatology Complejo Asistencial Universitario de León Calle Altos de Nava s/n León León 24003 Spain Search for other works by this author on: Oxford Academic Google Scholar C. Rodriguez‐Lage, C. Rodriguez‐Lage Department of Dermatology Complejo Asistencial Universitario de León Calle Altos de Nava s/n León León 24003 Spain Search for other works by this author on: Oxford Academic Google Scholar I. García‐Doval I. García‐Doval Department of Dermatology Complejo Asistencial Universitario de León Calle Altos de Nava s/n León León 24003 Spain Correspondence: Ignacio García‐Doval. E‐mail: lmvalladares84@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 4, 1 April 2015, Pages 1136–1139, https://doi.org/10.1111/bjd.13385 Published: 01 April 2015
DIFFERENCES IN PROGRESSION PATTERN OF LATE RESTENOSIS AFTER SIROLIMUS-ELUTING STENT AND PACLITAXEL-ELUTING STENT IMPLANTATION
Authors: Suguru Otsuru, Kazusige Kadota, Mitsuru Yoshino, Koshi Miyake, Haruki Eguchi, Yuki Hayakawa, Naoki Saito, Daiji Hasegawa, Yoshikazu Shigemoto, Seiji Habara, Takeshi Tada, Hiroyuki Tanaka, Shingo Hosogi, Yasushi Fuku, Naoki Oka, Harumi Kato, Hiroyuki Yamamoto, Tsuyoshi Goto, Kazuaki Mitsudo
Journal: Journal of the American College of Cardiology (2011)
Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population
Authors: Dennis E K Tan, Jia Nee Foo, Jin-Xin Bei, Jiang Chang, Roujun Peng, Xiaohui Zheng, Lixuan Wei, Ying Huang, Wei Yen Lim, Juan Li, Qian Cui, Soo Hong Chew, Richard P Ebstein, Ponnudurai Kuperan, Soon Thye Lim, Miriam Tao, Suat Hoon Tan, Alvin Wong, Gee Chuan Wong, Soo Yong Tan, Siok Bian Ng, Yi-Xin Zeng, Chiea Chuen Khor, Dongxin Lin, Adeline L H Seow, Wei-Hua Jia, Jianjun Liu
Journal: Nature Genetics (2013)
The Self-Referred Violent Patient
Authors: John R. Lion
Journal: JAMA (1968)

An increasing number of patients now enter hospitals voluntarily with chief complaints of episodic violence, impulsiveness, and destructive urges. Proper evaluation of these patients is often difficult, particularly when the patient is extremely agitated. This communication furnishes guidelines for handling violent patients when they enter a hospital facility. The physician's job has not ended when the patient's acute anxiety has been abated and/or hospitalization has been arranged. If possible, the etiology of the patient's violence should also be established. Are the patient's problems caused by neurological difficulties, psychiatric difficulties, or both? This communication shows how a careful history can help the physician determine whether neurological and/or psychiatric consultations are advisable.
Consultant--by any other name.
Authors: I M Librach
Journal: BMJ (1970)

regarding the subconsultant grade (31 Jan- uary, p. 304).Although I am happy to ac- cept that Mr. Bennett appears to have been misreported, nevertheless his suggestion is not one that would commend itself in any future staffing structure.Dr. Thompson stresses that his remarks were factual.However, by admitting that there are "medical assistants who already carry out
Cancer Supportive Care: A Comprehensive Guide for Patients and Their Families
Authors: David Casarett
Journal: Annals of Internal Medicine (2000)

Medical Writings: Book Notes5 September 2000Cancer Supportive Care: A Comprehensive Guide for Patients and Their FamiliesDavid Casarett, MD, MADavid Casarett, MD, MAUniversity of Pennsylvania Institute on Aging, Philadelphia, Pennsylvania. (Casarett)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-5-200009050-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Rosenbaum EH, Rosenbaum IR. 500 pages. Toronto: Somerville House; 1998. $24.95. ISBN 1894042115. Order phone 416-488-5938.Field of medicine: Oncology and palliative care.Format: Softcover book.Audience: Patients with cancer and their families.Purpose: To provide a comprehensive overview of issues that people with cancer and their families face.Content: The book begins with a succinct summary of cancer pathogenesis and therapy, including bone marrow transplantation and complementary medicine. The majority of the book is devoted to focused discussions of common problems and issues, such as sexuality, nutrition, and depression.Highlights: Readers will probably find the numerous specific examples and ... Author, Article, and Disclosure InformationAffiliations: University of Pennsylvania Institute on Aging, Philadelphia, Pennsylvania. (Casarett) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 September 2000Volume 133, Issue 5Page: 400KeywordsBone marrow transplantationCancer treatmentClinical trialsHealth care providersNauseaNutritionOpioidsPalliative carePathogenesisSoftware tools ePublished: 5 September 2000 Issue Published: 5 September 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
SOME REFLEX DISTURBANCES DUE TO PELVIC DISEASE.
Authors: JOHN MILTON DUFF
Journal: JAMA (1898)

Reflex disturbances in the human body from whatever cause, are generally a great source of annoyance to the practitioner. Especially is this the case when the original disease does not present marked symptoms, or at least where the reflex disturbance overshadows the real disease. These conditions make the diagnosis difficult and consequently the treatment is often misdirected. I will briefly report a few cases in point: <h3>Case 1.</h3> —Patient (A 3474, South Side Hospital case-book), Mrs. A. N., age 39 years, married fifteen years, no children. Family history good and excepting ordinary diseases of childhood has always been healthy until two years ago, when she began to show symptoms of chronic inflammatory pelvic disease. For the past three months she has been suffering from insomnia, sleep being procured only by the use of hypnotics. For some time her mental condition has been bad. Her conversation is now very incoherent. She
Frequent Detection of Genital Herpes Simplex Virus DNA by Polymerase Chain Reaction Among Pregnant Women
Authors: Richard W. Cone
Journal: JAMA (1994)

To investigate the prevalence and level of genital herpes simplex virus (HSV) among women at delivery.A prospective analysis of HSV by culture and by polymerase chain reaction (PCR) of genital specimens and by HSV serologic studies in 100 asymptomatic women in labor; prospective analysis of HSV by PCR among 50 seronegative nonpregnant women at a student health center; and retrospective analysis of genital specimens for HSV by PCR from 17 HSV culture-positive women with uninfected neonates and from two HSV culture-negative women with HSV-infected neonates. All pregnant women were at a university hospital.Presence of HSV by culture and levels of HSV by quantitative, type-specific PCR in cervical and vulvar specimens; HSV serologic testing by Western blot.All of the 100 asymptomatic women in labor who were studied prospectively were HSV culture negative. In nine HSV was recovered by PCR. Herpes simplex virus was recovered by PCR in one of the 50 seronegative nonpregnant women; she soon became seropositive. All 17 culture-positive women had HSV recovered by PCR. High levels of HSV DNA were obtained by PCR from the two culture-negative women with infected neonates. Among those from whom HSV was recovered by PCR, HSV DNA levels were 250 times higher from culture-positive samples than from culture-negative samples (11,571 genome equivalents vs 46 genome equivalents; P < .001).The frequency of infant exposure to HSV DNA-containing secretions from HSV-seropositive mothers is about eight times higher than previously reported using HSV culture methods. High maternal levels of HSV DNA may be associated with an increased frequency of transmission of HSV to the infant.
Reply to M. Darmon et al
Authors: Jorge E. Cortes
Journal: Journal of Clinical Oncology (2010)

of Clinical Oncology on the efficacy and safety of rasburicase alone or followed by allopurinol compared with allopurinol alone in controlling plasma uric acid in adults at risk for tumor lysis syndrome (TLS).The optimal dosage and timing of rasburicase is an important research question; however, on the basis of available data, we cannot
U.S. cancer mortality 1950-1978: a strategy for analyzing spatial and temporal patterns.
Authors: K G Manton, E Stallard, J P Creason, W B Riggan
Journal: Environmental Health Perspectives (1985)

There are a number of technical and statistical problems in monitoring the temporal and spatial variation of local area death rates in the United States for evidence of systematically elevated risks. An analytic strategy is proposed to reduce one of the major statistical concerns, i.e., that of identifying areas with truly elevated mortality risks from a large number of local area comparisons. This analytic strategy involves two stages. The first is a procedure for examining the entire distribution of local area death rates instead of simply selecting high risk "outliers." The second is the development of an analytic procedure to relate the temporal changes in the cross-sectional distribution of local area death rates to models of the disease process operating within the populations in those areas. The procedures are applied to data on cancer mortality for the 3050 counties (or county equivalents) of the United States over the period 1950 to 1978. A number of striking mortality patterns, both within the entire United States and within various regions and states, are identified. For example, perhaps the most persistent finding was that the risk increases in the death rates for respiratory cancer mortality were due to a "catching up" of nonmetropolitan county mortality rates with metropolitan area mortality rates.
Progression of Coronary Artery Disease
Authors: CHARLES E. BEMIS, RICHARD GORLIN, HARVEY G. KEMP, MICHAEL V. HERMAN
Journal: Circulation (1973)

Significant progression of coronary artery disease was seen in 52% of subjects studied by selective cinearteriography at intervals between 2 and 75 months (average 23.8). Subsequent progression, although confined to proximal areas, was independent of overall severity of initial disease or previous disease at the site of progression and occurred frequently in previously normal vessels. Plasma lipid abnormalities and myocardial lactate production at the time of the initial study were significantly associated with subsequent arteriographic progression. Similarly abnormal glucose tolerance was seen more frequently in patients exhibiting progression than in those who did not. The progression occurring in patients with lipid abnormalities was more severe and more widespread than in other patients, and apparent interval reduction in lipid values did not influence the ultimate course of the atheromatous process. Myocardial infarction was almost invariably associated with progression. Collateral coronary circulation never increased or appeared unless accompanied by an increase in the extent of local coronary artery disease. The absence of progression was associated with a favorable prognosis. All other clinical, laboratory, and arteriographic parameters analyzed were not predictive of subsequent progression of the coronary obstructive lesion.
Teaching and Learning in Medical School
Authors: John H. Talbott
Journal: JAMA (1961)

The expenditure of energy in learning and teaching in medical school is not reflected in the number of monographs or discussions on this subject. Furthermore, it is unusual to find a volume devoted especially to medical pedagogy. The data presented by Miller represent the substance of conferences, seminars, and planned group discussions sponsored by the Commonwealth Fund, that were held over a period of 5 years at the University of Buffalo. The leaders of the discussion groups and the contributors to the volume participated as representatives of the departments of education and psychology in the university and as representatives of the departments of medicine and psychiatry in the medical school. The product is a readily readable contribution that begins with a discussion of the medical student, proceeds to consider the process of learning, details the tools of instruction, and concludes with evaluation of results. The presentation of data and concepts
Hemorrhagic Pleural Effusion in Patients Undergoing Chronic Hemodialysis
Authors: Malcolm A. Galen, Steven M. Steinberg, Edmund G. Lowrie, J. Michael Lazarus, C. L. Hampers, John P. Merrill
Journal: Annals of Internal Medicine (1975)

Three patients maintained on chronic hemodialysis developed hemorrhagic pleural effusion. The effusions seemed to be solely related to the uremic state, other causes having been excluded. Pulmonary restriction requiring decortication occurred in one patient. We concluded that hemorrhagic pleural effusion may be a complication of uremia in the chronically dialyzed patient and that fibrous pleuritis causing pulmonary restriction may result.
Phase 2 and phase 3 multicentre studies demonstrate the potential for glycans as predictive biomarkers in barrett's oesophagus
Authors: E. L. Bird-Lieberman, J. M. Dunn, P. Lao-Sirieix, H. G. Mullholland, C. E. Moore, K. Arthur, D. McManus, M. M. Novelli, L. B. Lovat, L. Murray, R. C. Fitzgerald
Journal: Gut (2011)

<h3>Introduction</h3> The prognosis of oesophageal adenocarcinoma (AC) is dramatically improved if detected early. Endoscopic surveillance currently relies on detection of dysplasia which lacks sufficient accuracy and alternative biomarkers are required. <h3>Hypothesis</h3> Alterations in complex glycan structures on the oesophageal epithelium alter in the pathway to AC and can be used as biomarkers which can be detected using either antibody or lectin probes. <h3>Aims</h3> (1) Identify and validate (EDRN phase 2) potential glycan biomarkers in BE. (2) Apply promising biomarkers to a case control cohort (EDRN phase 3). <h3>Methods</h3> Gene set enrichment analysis for glycan pathways was applied to gene expression data from AC samples (n=55) and samples representative of the stages of progression to AC (n=21). External protein validation of candidate glycan genes was performed using immunohistochemistry on paraffin-embedded sections (n=80) from patients known to have a diagnosis of HGD or early AC within BE. A retrospective longitudinal repository study using a nested case control approach was under taken on patients (n=9332) within the Northern Ireland Barrett9s Registry of patients diagnosed with BE between 1993 and 2005. Cases (n=69) were defined as those who progressed to either AC or HGD (with independent histopathological confirmation by 2 experts) at least 6 months after their initial diagnosis; matched (by age, sex and initial year of diagnosis) in up to 5 controls (n=320). Characteristics between cases and controls were compared using independent t tests for continuous variables and χ<sup>2</sup> tests for categorical variables. Conditional logistic regression was conducted to estimate odds ratios. <h3>Results</h3> Gene expression analysis shortlisted genes with the greatest altered expression in dysplasia and AC. 5 of the 6 top genes contribute to the synthesis of Lewis (Le) glycan groups. External immunohistochemistry validation confirmed sialyl Le<sup>a</sup> and Le<sup>x</sup> expression to increase significantly in the progression to AC on the apical epithelial membrane (p&lt;0.00001) and in the epithelial cytoplasm (p&lt;0.001). Increased sLe<sup>a</sup> expression was partially at the expense of a decreased expression within the epithelial mucous globules (p&lt;0.01). Multivariate analysis of the nested case control cohort revealed the staining of sLe<sup>a</sup> to be predictive of progression to HGD or AC (p&lt;0.001). <h3>Conclusion</h3> Glycan biomarkers can predict progression in biopsies taken at BE diagnosis in a phase 3 study. A phase 4 prospective screening study is warranted to confirm the sensitivity and specificity of these biomarkers.
Neural induction: a bird's eye view
Authors: Andrea Streit, Claudio D Stern
Journal: Trends in Genetics (1999)

Since the discovery of the phenomenon of neural induction by Spemann and Mangold in 1924, considerable effort has been invested in identifying the signals produced by the organizer that are responsible for diverting the fate of cells from epidermal to neural. Substantial progress has been made only recently by the finding in amphibians that BMP4 is a neural inhibitor and epidermal inducer, and that endogenous antagonists of BMPs are secreted by the organizer. However, recent results in the chick point to the existence of other, upstream events required before BMP inhibition stabilizes neural fates. Here we take a critical view of the evidence for and against the view that BMP inhibition is a sufficient trigger for neural induction in different vertebrates.
Histopathological correlates of unstable ischemic syndromes in patients undergoing directional coronary atherectomy
Authors: Germano Disciascio, Danna Johnson, Kim Koolly, George Vetrovec, Evelyne Goudreau, Ravinder Kohli, Nagui Sabri, Mark Warner, Michael Cowley
Journal: Journal of the American College of Cardiology (1991)
The Prognostic Value of E-Cadherin, α-, β-, and γ-Catenin in Urothelial Cancer of the Upper Urinary Tract
Authors: Keishi Kashibuchi, Kyoichi Tomita, Jack A. Schalken, Haruki Kume, Takuhiro Yamaguchi, Satoru Muto, Sigeo Horie, Tadaichi Kitamura
Journal: European Urology (2006)
Respiratory Aspiration of Stomach Contents
Authors: JAMES W. WYNNE
Journal: Annals of Internal Medicine (1977)

The aspiration of stomach contents is a common clinical problem of concern to all physicians. Its consequences are varied, depending on the amount and distribution of the aspirate, its pH, and the presence or absence of food, particulate matter, and bacteria. Because multiple factors are involved, aspiration of stomach contents can lead to several distinct syndromes of pulmonary injury, all of which unfortunately have been labeled "aspiration pneumonitis." We review the pathophysiology of each of these syndromes and discuss important diagnostic and therapeutic consequences.
ATROPINE COMA: A SOMATIC THERAPY IN PSYCHIATRY
Authors: GORDON R. FORRER, JACOB J. MILLER
Journal: American Journal of Psychiatry (1958)

A somatic therapy for the treatment of selected cases of mental illness is described. Coma is produced by the administration of massive doses of atropine and terminated by physostigmine. Increased accessibility, better contact with reality, and more appropriate affective responses are found immediately after termination of coma, persisting several hours, providing the opportunity for more effective psychotherapeutic assistance.
Decrements in spirometry values associated with chlorine gassing events and pulp mill work.
Authors: P K Henneberger, M B Lax, B G Ferris
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

In a previous study of older pulp and paper workers in Berlin, New Hampshire, decrements in spirometry results associated with accidental exposures to high levels of irritant gases depended on cumulative levels of pulp mill exposure and cigarette smoking. Many of those subjects were older and retired. A new study was initiated to assess whether gassing events were a problem among current workers. Three hundred white male pulp and paper workers from the mill in Berlin, New Hampshire, were surveyed in 1992. Testing included spirometry and questionnaires. The mean age was 40.4 yr, and the mean tenure with the company was 18.5 yr. A total of 105 of the 300 subjects (35%) reported ever having an episode of high exposure to chlorine gases (i.e., being gassed). The percentage gassed was 51% for pulp mill workers and only 13% for other employees. For subjects with no more than 26 pack-years of cigarette smoking, obstruction (i.e., abnormally low FEV1 and FEV1/FVC) was observed only among those with a history of gassing. Also, the combination of high cigarette smoking (i.e., > 26 pack-years) and gassing had a greater than additive effect on obstruction. These findings suggest that additional controls are needed to minimize the number of gassing events in this and other chemical pulp mills.
Connotations of 'Hispanic'
Authors: Rafael J. Igartua
Journal: JAMA (1981)

<h3>To the Editor.—</h3> This letter is in reference to the article "Systemic Lupus Erythematosus—Survival Patterns" (1981;245:934). In Table 1, p 935, the patients are classified under "Race," including "Hispanic." A classification of patients according to race in an epidemiologic study is valid only if the members of a particular race share a common genetic background. This common genetic background may or not explain the preponderance or the severity of a given disease in a particular racial group. The term "Hispanic," like the terms "Jewish," "Irish," and "Polish," as used in the United States denotes an ethnic or a cultural background. A "Hispanic" person may be of European, African, or Oriental origin, or any combination of these. Therefore, it is erroneous to use the term "Hispanic" as a synonym for a racial category. If an epidemiologic study is investigating the influence of ethnicity and cultural background in a given disease, then
Oral Contraceptives, Thrombosis, and Sickle Cell Hemoglobinopathies
Authors: Roy L. Haynes
Journal: JAMA (1967)

IN A CASE previously reported by us,<sup>1</sup>pulmonary infarction occurred in a patient who had sicklethalassemia disease and was taking an oral contraceptive. During pregnancy, the patient had a similar episode. Oral contraceptives, while not primary agents in intravascular coagulation, may cause thromboembolism in women with predisposing conditions.<sup>2</sup>We have not seen a report documenting the concurrence of thrombosis, sickle cell hemoglobinopathy, and the use of oral contraceptives. Two additional cases noted here suggest that sickle cell hemoglobinopathies may be a contraindication to the administration of the contraceptive drugs. <h3>Report of Cases</h3><h3>CASE 1.—</h3> A 26-year-old, gravida 3, para 3, Negro woman with sickle cell—hemoglobin C disease had had no thromboembolic episode until the eighth month of use of an oral contraceptive (norethynodrel with mestranol [Enovid] 5 mg daily), when she experienced sudden fever, chest pain, and a cough. She was hospitalized, and a diagnosis of pneumonitis with