tbuckley/cabot-search huggingface dataset:
Natural Anti-Amyloid-beta Antibodies in Intravenous Immunoglobulin (IVIG) Preparation Attenuate Amyloid beta-Induced Neurotoxicity in vitro
Authors: C. Hermann, H.P. Schwarz, H. Ehrlich, B.M. Reipert, K. Olas
Journal: Journal of Allergy and Clinical Immunology (2009)
LUPUS ERYTHEMATOSUS AS A SYSTEMIC DISEASE
Authors: WILLIAM H. GOECKERMAN
Journal: JAMA (1923)

The clinical picture of localized or discoid lupus erythematosus, with which I wish to contrast the disseminate form with constitutional manifestations, is familiar to most practitioners. The conception of a grave form of lupus erythematosus with severe systemic disturbances and with the extension of the local process originated with Kaposi. In 1872 he first called attention to the presence of toxic symptoms, and was evidently familiar with the hyperpyrexial attacks occasionally seen when discoid lesions are present. Very little has been added to an understanding of the disease since his time. Boeck 1 temporarily confused the problem when he designated lesions on the fingers, which can now probably be classified with Darier's folliclis, as lesions of disseminate lupus erythematosus. The whole matter was probably still more obscured by the French tendency to enumerate a large number of subclasses of lupus erythematosus which essentially are only different degrees of the same
Reply to A. Chan et al
Authors: Axel Grothey, Charles L. Loprinzi, Jeff Sloan
Journal: Journal of Clinical Oncology (2011)

It is our pleasure to respond to the comments and questions from Chan et al 1 regarding our recent publication. 2lthough patients with pre-existing peripheral neuropathy were excluded from our study, patients with conditions that could predispose them for the development of neurotoxicity, such as diabetes, were allowed to be included.Because of the vast spectrum of the diagnosis of diabetes (eg, severity and duration), information was not collected about such a diagnosis.Likewise, we did not control for, nor collect information about, the use of over-the-counter supplements and the use of diuretics.
Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia
Authors: Caroline M. Bateman, Susan M. Colman, Tracy Chaplin, Bryan D. Young, Tim O. Eden, Manoo Bhakta, Eric J. Gratias, Elisabeth R. van Wering, Giovanni Cazzaniga, Christine J. Harrison, Richard Hain, Philip Ancliff, Anthony M. Ford, Lyndal Kearney, Mel Greaves
Journal: Blood (2010)
Chlorphentermine S.A. in the Treatment of Obesity and the Effect of Weight Loss on Steroid Excretion
Authors: I. M. D. Jackson, W. G. Whyte
Journal: BMJ (1965)

A number of trials have been undertaken to test the efficacy of chlorphentermine (l-(p-chlorophenyl)-2-methyl 2-amino propane hydrochloride ; Lucofen) as an anorectic agent, and it has been shown to be superior to placebo (Lucey and Hadden, 1962 ; Levin et al., 1963). Recently a sustained-action chlor phentermine (chlorphentermine S.A.) has become available and has been used by Seaton et al. (1964) in a group of patients with refractory  as defined by Duncan et al. (1960). Their results showed a small but significant loss of weight after six weeks by patients on chlorphentermine S.A. compared with those on a dummy preparation, but thereafter the loss of weight was not significant. For many obese patients the difficulties in losing weight by adherence to low-calorie diets are immense, and the availability of a drug which can act as an appetite suppressant would theoretically seem of advantage in such cases. In practice the anorectic agents, most of which are derived from amphetamine, have not only proved disappointing in the management of obesity but have also produced serious side-effects, including habituation and addiction (Kiloh and Brandon, 1962). Modell (1960) has suggested that the anorexigenic action of the amphetamines is closely related to their cortical excitatory action, a fact which probably accounts for their addictive quali ties. Chlorphentermine differs chemically from amphetamine (see Formulae) and appears to be metabolized differently, prob ably owing to the para-chloro substitution ; certainly neither in experimental animals (Holm et al., 1960) nor in therapeutic dosage in clinical practice (Levin et al., 1963) has chlorphentermine been reported to produce cortical stimulation.
Saline infusion via local drug delivery catheters is associated with increased neointimal hyperplasis in a porcine coronary in-stent restenosis model
Authors: W.H. Kim, M.K. Hong, R. Kornowski, F.O. Tio, H. Wu, R. Seabron, T. Pierre, S. Collins, M.B. Leon
Journal: Journal of the American College of Cardiology (1998)
Patch Closure of Muscular Ventricular Septal Defects With a New Hybrid Therapy in a Pig Model
Authors: Rainer Kozlik-Feldmann, Nora Lang, Regine Aumann, Anja Lehner, Darius Rassoulian, Ralf Sodian, Christoph Schmitz, Martin Hinterseer, Rabea Hinkel, Eckart Thein, Franz Freudenthal, Nikolay V. Vasylev, Pedro J. del Nido, Heinrich Netz
Journal: Journal of the American College of Cardiology (2008)
Shrinking Federal Support Brings New Era to Education in the Health Professions
Authors: John K. Iglehart
Journal: New England Journal of Medicine (1981)

Major changes in the federal government's relations with medical education are evolving under the pressures of dwindling resources and the Reagan administration's intent to transform government's role into that of intervenor and funder of last resort. These policy initiatives will lead to major changes in the financing of medical education by forcing a greater reliance on state support, students' tuition, research dollars, patient-care fees, and private philanthropy.The latest reflection of these evolving changes in the federal attitude toward medical education is contained in a massive new law, vigorously promoted by the administration, that will reverse a pattern of governmental . . .
HOW MUCH DOES THE LEFT MAIN BIFURCATION ANGLE CHANGE THROUGHOUT THE CARDIAC CYCLE? QUANTITATIVE IMPLICATIONS FOR LEFT MAIN BIFURCATION STENT DESIGNS
Authors: Chauncy B. Handran, John R. Lesser, Timothy D. Henry, Michael Gilmore, Kelly Wickstrom, Robert S. Schwartz
Journal: Journal of the American College of Cardiology (2011)
Molecular distinctions between pediatric and adult mature B-cell non-Hodgkin lymphomas identified through genomic profiling
Authors: Karen E. Deffenbacher, Javeed Iqbal, Warren Sanger, Yulei Shen, Cynthia Lachel, Zhongfeng Liu, Yanyan Liu, Megan S. Lim, Sherrie L. Perkins, Kai Fu, Lynette Smith, James Lynch, Louis M. Staudt, Lisa M. Rimsza, Elaine Jaffe, Andreas Rosenwald, German K. Ott, Jan Delabie, Elias Campo, Randy D. Gascoyne, Mitchell S. Cairo, Dennis D. Weisenburger, Timothy C. Greiner, Thomas G. Gross, Wing C. Chan
Journal: Blood (2012)
Use it or lose it?
Authors: I. Robertson
Journal: BMJ (1995)

One of the worst things about getting older is becoming stupider. It's not, I'm afraid, just a matter of losing the edge off your memory. The gruesome fact is that, on standard tests of raw intelligence which do not rely on stored up knowlege or well rehearsed mental skills, from the mid-20s onwards your mental abilities steadily decline. Now 90% of jobs are 90% routine, and age may confer advantage to the routine via long experience and hugely practised skills, but non-routine problem solving is better done by the young. Hence most mathematicians have to make their names and find their chairs in …
Points: Drugs in developing countries
Authors: C J Burns-Cox, J. Yeo
Journal: BMJ (1986)

Carpal tunnel syndrome (CTS) is a common form of peripheral nerve entrapment, which is observed due to compression of the median nerve at the level of the carpal tunnel in the wrist. Bifid median nerve and persistent median artery association are rare, and they may be independent risk factors for CTS. These rare entities are usually asymptomatic, but in cases of acute thrombosis or dilatation of the persistent median artery, acute findings can be seen. We report a case of acute CTS due to thrombosis of a persistent median artery and associated bifurcated median nerve during pregnancy.
Shunting through a patent foramen ovale.
Authors: E Berglund
Journal: Thorax (1992)

Letters to the Editor potential for confounding by severity when an unmatched control group is used.A similar problem occurred in the Saskatchewan study,7 which also used an unmatched control group.When this problem is correc- ted, however, either by using an appropriate control group (group A) or by adjusting for markers of asthma severity (table, top of p574), then the association of asthma drugs in general with deaths from asthma tends to disappear, whereas the findings for fenoterol remain firm (a similar pattern occurred in the Saskatchewan data7).The table shows that control group A provides an adequate match for asthma severity, whereas some confound- ing exists in the unadjusted results for control group B. We drew this conclusion in the published paper,5 and Dr Lanes and his coworkers have simply repeated our analysis but misrepresented our conclusions.When the hazards of fenoterol are being considered it is important that all of the evidence should be considered.There is now a wealth of epidemiological, experimental, and clinical evidence that fenoterol is more hazardous than other commonly used f agon- ists.2The second New Zealand mortality epidemic started when fenoterol was introduced in 1976, and continued until our first study was published in 1989; the death rate then fell by one half, and is now similar to that in other countries.It is important to search for alternative explanations, but the evidence increasingly indicates that confounding by severity is not a plausible explana- tion, and that the association between fenoterol and deaths from asthma is likely to be causal.
Pulsatile Blood Flow
Authors: William R. Milnor
Journal: New England Journal of Medicine (1972)

Hence does arise the action and function of the heart, which by pulsation it performs. [William Harvey, De Motu Cordis, 1628.]THE study of blood flow as a pulsatile phenomenon is scarcely new, but it has gained new impetus from three recent developments: the commercial production of reliable blood flowmeters, the formulation of theories appropriate to oscillatory flow in blood vessels,1 and the increasing availability of digital computers. Studies in laboratory animals have profited from these technical advances for some time, and clinical investigation of pulsatile flow is now possible with catheter-tip flowmeters that can be used in routine cardiac . . .
Adjuvant chemotherapy for breast cancer – prognostic impact of relative dose-intensity.
Authors: S Kahlert, J Rosenfeld, K Mair, Y Sorokina, J Engel, K Friese
Journal: Cancer Research (2009)

Abstract Abstract #4109 Introduction: Maintenance of adequate dose intensity (DI) is an important aim in the use of adjuvant chemotherapy for early breast cancer. Some studies report a decreased survival, if the DI is below 80% of the planned dose. We evaluated the rate of decreased DI and its prognostic impact for patients (pts.) treated in our institution between 1990 and 2004. During the long observation period a variety of regimens were used: CMF, normal dosed anthracycline (norA) based regimens (Epirubicin less than 35 mg/sqm*week) and higher dosed anthracyclines (hiA; Epirubicin doses of more than 45 mg/sqm*week).&amp;#x2028; Methods: All patient files were reviewed to calculate relative DI; cycles not applied were treated as a 100% dose reduction. Follow up-data were taken from our institutional prospective data base and the regional tumor registry. Excluded from the analysis were pts. with high dose chemotherapy with stem cell support, rare regimens (less than 10 cases / regimen), pts. switching institution during therapy and pts. progressing during chemotherapy.&amp;#x2028; Results: From 966 pts. receiving adjuvant chemotherapy, 887 matched the inclusion criteria. Mean follow up is 70 months with 260 distant progressions and 234 deaths. 193 pts. received CMF, 442 norA and 252 hiA, 302 pts. received taxanes. Preterm termination of chemotherapy occurred in 77 pts (8.7%), dose reductions in 36 pts. (4.1%). Pts. receiving hiA were at higher risk for dose reductions than with norA and CMF (7.5% vs. 2.9% vs. 2.1%, p=0.015). Mean dose delays were 12.7 days (CMF), 6.4 days (norA) and 5.7 (hiA) (p&amp;lt;0.01, Kruskal-Wallis-test). The mean rel. DI were 90% (CMF), 93% (norA) and 92% (hiA) and significantly different (p=0.01, Kruskal-Wallis-test).&amp;#x2028; In univariate analysis, 5 year-metastasis free survival (MFS, 74% vs. 55%, p=0.002) and overall survival (OAS, 80% vs. 65%, p=0.009) are significantly lower for pts. with a rel. DI of less than 80%. This effect seems more pronounced for norA (OAS 80% vs. 45%), than for CMF (OAS 74% vs. 74%) and hiA (OAS 85% vs. 77%). The adverse effect of low DI was independent of taxan-use. In a cox-regression analysis low DI was not identified as independent predictor for MFS and OAS.&amp;#x2028; Conclusions: Compared to DI reported from most prospective randomised trials the DI in this study seems lower, potentially reflecting patient selection. Dose reductions, delays and preterm termination are common findings, leading to impaired DI. In our study low DI is associated with adverse prognosis in univariate, but not in multivariate analysis. Nevertheless, unnecessary dose modifications should be avoided. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 4109.
Basic and clinical research merge at center
Authors: Kathryn Simmons
Journal: JAMA (1984)

The Clinical Center of the NIH is where the often-parallel paths of basic and clinical research converge.  Ever since the first patient was admitted in 1953, the Clinical Center has actively promoted and fostered the relationship between basic and clinical scientists and their work. Its physical structure is the most eminent example: On each floor of the 540-bed hospital, patient care facilities line one hall while research laboratories line another, allowing close collaboration and consultation between the 935 senior staff and postgraduate fellows.  Furthermore, says Center Director John L. Decker, MD, disease areas—rather than the usual science disciplines—determine the Clinical Center's organization. One ward, for example, may be devoted to heart disease, with specialists from all related fields working together toward a common goal. Trainees, too, transfer knowledge between patient care wards and research laboratories because they spend time on both.  It is strictly a research operation, a research hospital,
Genetic ancestry influences asthma susceptibility and lung function among Latinos
Authors: Maria Pino-Yanes, Neeta Thakur, Christopher R. Gignoux, Joshua M. Galanter, Lindsey A. Roth, Celeste Eng, Katherine K. Nishimura, Sam S. Oh, Hita Vora, Scott Huntsman, Elizabeth A. Nguyen, Donglei Hu, Katherine A. Drake, David V. Conti, Andres Moreno-Estrada, Karla Sandoval, Cheryl A. Winkler, Luisa N. Borrell, Fred Lurmann, Talat S. Islam, Adam Davis, Harold J. Farber, Kelley Meade, Pedro C. Avila, Denise Serebrisky, Kirsten Bibbins-Domingo, Michael A. Lenoir, Jean G. Ford, Emerita Brigino-Buenaventura, William Rodriguez-Cintron, Shannon M. Thyne, Saunak Sen, Jose R. Rodriguez-Santana, Carlos D. Bustamante, L. Keoki Williams, Frank D. Gilliland, W. James Gauderman, Rajesh Kumar, Dara G. Torgerson, Esteban G. Burchard
Journal: Journal of Allergy and Clinical Immunology (2014)
A surgical thought on disaster relief.
Authors: P. J. Guy
Journal: BMJ (1989)

less than their median lethal dose.Comparative figures from Toronto show that at the Ontario Trauma Centre, which has an organised trauma system, only 6% of patients die with an injury severity score less than their median lethal dose.'The equivalent figure for other roronto hospitals of a similar standard but lacking an organised trauma system was 53%.I also examined the problems entailed in transferring patients with multiple injuries from outlying hospitals to the Royal Infirmary.In this group half were mismanaged in the outlying hospital to an extent that might have contributed to their death.About 350 patients with multiple injuries are admitted each year to the Royal Infirmary, but despite the skill that should accompany this work- load up to 70% of the hospital deaths after a road traffic accident seem to be avoidable.The reasons for this are twofold.Firstly, trauma has a low priority within the medical profession to the extent that decision making and treatment are frequently undertaken by junior staff with little experience.Secondly, poor communication exists among the various surgical disciplines, ensuring poor management of patients.The facilities in the hospital for dealing with those with multiple injuries are dreadful.The lack of high dependency and intensive care beds means that patients are usually managed in ordinary wards and if ventilation is required it is usually delayed.The ideal situation is the creation of trauma centres as suggested by the recent report, but until these are established we need to rethink our approach to trauma and to expand existing facilities if my unpalatable statistics for the Royal Infirmary are to be improved.
Analysis of bronchial reactivity in epidemiological studies.
Authors: M J Abramson, N A Saunders, M J Hensley
Journal: Thorax (1990)

The measurement of bronchial reactivity in epidemiological studies has the advantage of quantifying an objective physiological feature of asthma. Bronchial reactivity was developed in a clinical setting and has been conventionally expressed as the dose of agonist producing a 20% fall in FEV1 (PD20). As PD20 can be estimated for less than 20% of subjects in general community surveys with the doses of agonist that are usually given, data from most subjects must be censored. Thus PD20 alone is a poor index of bronchial reactivity for epidemiological studies. Data from 809 aluminium smelter workers were used to evaluate alternative methods of analysing bronchial reactivity. Dose-response relationships were analysed by four methods: (1) PD20 by the conventional method of interpolating the dose on a logarithmic scale between the last two measurements of FEV1; (2) PD20 (with allowance for extrapolation), estimated by fitting an exponential curve to the dose-response data; (3) the linear regression slope between dose and FEV1 when significant; (4) the dose-response slope obtained in all subjects as the % change in FEV1 from baseline in response to total dose. When each of these measures was related to symptoms, diagnosis, and treatment of asthma, all differentiated between "asthmatic" and "non-asthmatic" subjects. The dose-response slope (method 4) had the advantages of simplicity and no censored data, and was shown to be clinically relevant. It is suggested that the dose-response slope should be used for the analysis of bronchial reactivity in epidemiological studies.
Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids
Authors: Wenshan Wang, Na Lv, Shasha Zhang, Guanghou Shui, Hui Qian, Jingfeng Zhang, Yuanying Chen, Jing Ye, Yuansheng Xie, Yuemao Shen, Markus R Wenk, Peng Li
Journal: Nature Medicine (2012)
Histomorphometric features of bone in patients with primary and secondary hypoparathyroidism
Authors: Yoshifumi Ubara, Tomohisa Fushimi, Tetsuo Tagami, Naoki Sawa, Junichi Hoshino, Masafumi Yokota, Hideyuki Katori, Fumi Takemoto, Shigeko Hara
Journal: Kidney International (2003)
PLAQUE RUPTURE IS ASSOCIATED WITH LARGER INFARCT SIZE FOLLOWING SUCCESSFUL PERCUTANEOUS CORONARY INTERVENTION IN ST-SEGMENT ELEVATION ACUTE MYOCARDIAL INFARCTION
Authors: Keisuke Satogami, Yasushi Ino, Kohei Ishibashi, Kenichi Komukai, Takashi Tanimoto, Hironori Kitabata, Keizo Kimura, Kumiko Hirata, Masato Mizukoshi, Toshio Imanishi, Takashi Akasaka
Journal: Journal of the American College of Cardiology (2011)
The Question of Irradiation Therapy in Lung Cancer
Authors: Melvin J. Krant
Journal: JAMA (1966)

The techniques for medical diagnosis and treat ment have changed in an extraordinary fashion in this 20th century. The application of engineering and scientific principles to medical investigation has altered our awareness of the many-sided manifestations of clinical disorders. No better example of a "changing" illness is to be found than primary lung cancer. Formerly a relatively rare disease in most European and American communities, lung cancer has achieved an "epidemic" status in the past three decades. Unfortunately, newer knowledge of the nature of the disease has not been paralleled by the development of curable treatments. The poor cure-rate by surgery has resulted in the frequent use of radiation treatment both to extend the life expectancy of the victim of the illness, and for palliation of his complaints. As an internist concerned with the medical management of patients with bronchogenic cancer, I have become confused as to the appropriate value
Abstract 3499: Anti-adenoma Adnab-9 antibody recognizes a serum GI cancer candidate biomarker.
Authors: Martin Tobi, Douglas Weinstein, Emma Vizgoft, Susanne Pedersen
Journal: Cancer Research (2013)

Abstract Population-based serum banks may allow for the early detection of shed markers of common gastrointestinal cancers. Few GI pan-biomarkers are available for serum testing and those that are lack specificity and universal sensitivity for colorectal, gastric and pancreatic cancers. The p87 antigen recognized by the Adnab-9 antibody may be an ideal candidate for such a biomarker. It has both diagnostic and prognostic biomarker ability for these GI cancers but its ability to detect the antigen in serum is unknown. Methods: In order to gauge feasibility of serum testing we conducted a literature search to determine the existence of model established serum banks internationally. An indirect Adnab-9 ELISA was performed on a validation set of sera from 20 CRC patients and 10 controls. A known positive stool extract was used as the positive control. Results: Six countries were found to possess serum banks with the numbers of specimens ranging from 1,982 to 2,132,215. Of these 6 countries, age-adjusted mortality from CRC was highest in the Netherlands at 21/100,000, from gastric cancer highest in Japan 35/100,000 and from pancreatic cancer highest in the USA 11/100,000. The validation sera set Australian patient demographics were similar for gender and ethnicity. The controls were significantly younger than the cancer patients (64±10.3 versus 52.2±3.4 years [p&amp;lt;0.002]) but there was no direct linear correlation between OD450 and age (r2=0.104;p=0.102). Dilution of serum at both 1:1 and 1:3 ratios showed significantly different mean OD450 values between cancer and control patients of 0.076±0.007 (x±STDEV) versus 0.069±0.006 (p&amp;lt;0.025) and 0.083±0.008 versus 0.074±0.004 (p&amp;lt;0.02) respectively. Eighty percent of cancer patients’ serum were positive versus 30% of controls (OR 9.3; CI 1.6-53.2;p&amp;lt;0.015). Signal to noise ratios of the positive control was satisfactory with the lowest OD450 reading at 0.085 obtained at a 1:6,400 dilution with a linear dilution-reaction curve. Conclusions: National serum banks already exist that could allow for graduated targeted screening of a specific disease based on relative mortality rates. The Adnab-9 antibody is a promising candidate for a pan-biomarker based on the outcome of the indirect ELISA. Since sensitivity of Adnab-9 stool binding is lowest for CRC compared to gastric and pancreatic, it is likely that serum testing for the other 2 cancers would yield comparable results. In order to elucidate this further, testing in prospective studies should be undertaken. Citation Format: Martin Tobi, Douglas Weinstein, Emma Vizgoft, Susanne Pedersen. Anti-adenoma Adnab-9 antibody recognizes a serum GI cancer candidate biomarker. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3499. doi:10.1158/1538-7445.AM2013-3499