THE SYNDROME OF EXOPHTHALMOS, HYPERTROPHIC OSTEOARTHROPATHY AND LOCALIZED MYXEDEMA: A REVIEW OF THE LITERATURE AND REPORT OF A CASE*
Authors: Monroe Thomas Diamond
Journal: Annals of Internal Medicine (1959)

Case Reports1 January 1959THE SYNDROME OF EXOPHTHALMOS, HYPERTROPHIC OSTEOARTHROPATHY AND LOCALIZED MYXEDEMA: A REVIEW OF THE LITERATURE AND REPORT OF A CASE*MONROE THOMAS DIAMOND, M.D., F.A.C.P.MONROE THOMAS DIAMOND, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-1-206 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough hypertrophic osteoarthropathy has been noted in association with a wide variety of primary disorders,1its occurrence with diseases of the thyroid has been little mentioned in the literature. In 1919 Ebstein2briefly reported a case of clubbing of the fingers developing in a 24 year old male following thyroidectomy for exophthalmic goiter. Thomas3in 1933 described in detail a patient who, eight months after having had a subtotal thyroidectomy for exophthalmic goiter, developed progressive hypertrophic osteoarthropathy and a concurrent brawny and pigmented edema of the legs consistent with myxedema. Thomas felt that the rapid change in thyroid function following...Bibliography1. Mendlewitz M: Clubbing and hypertrophic osteoarthropathy, Medicine 21: 269, 1942. CrossrefGoogle Scholar2. Ebstein E: Angeborene familiare Erkrankungen an den Nageln, Dermat. Wchnschr. 68: 113, 1919. Google Scholar3. Thomas HM: Acropachy. Secondary subperiosteal new bone formation, Arch. Int. Med. 51: 571, 1933. CrossrefGoogle Scholar4. Cushing EH: "Club fingers" and hypertrophic pulmonary osteoarthropathy, Internat. Clin. 2: 200, 1937. Google Scholar5. RynearsonSacasa EHCF: Hypertrophic pulmonary osteoarthropathy (acropachy) afflicting a patient who had postoperative myxedema and progressive exophthalmos, Proc. Staff Meet., Mayo Clin. 16: 353, 1941. Google Scholar6. Greene R: Thyroid acropachy, Proc. Roy. Soc. Med. 44: 159, 1951. CrossrefMedlineGoogle Scholar7. Levitt R: The thyroid. A physiological, pathological, clinical, and surgical study, 1954, E. and S. Livingstone, Ltd., Edinburgh and London, p. 325. Google Scholar8. BloomHerrmannSharlit DFJH: Local injections of a preparation of hyaluronidase in the treatment of mucinous infiltration of the skin, J. Invest. Dermat. 12: 339, 1949. CrossrefMedlineGoogle Scholar9. Grais ML: Local injections of a preparation of hyaluronidase in the treatment of localized (pretibial) myxedema, J. Invest. Dermat. 12: 345, 1949. CrossrefMedlineGoogle Scholar10. Rosman D: The treatment of localized (pretibial) myxedema with hyaluronidase, New York State J. Med. 50: 1939, 1950. MedlineGoogle Scholar11. Personal observation. Google Scholar12. VoglBlumenfeldGutner ASL: Diagnostic significance of pulmonary hypertrophic osteoarthropathy, Am. J. Med. 18: 51, 1955. CrossrefMedlineGoogle Scholar13. PattisonBeckMiller JDEWB: Hypertrophic osteoarthropathy in carcinoma of the lung, J. A. M. A. 146: 783, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chappaqua, N. Y.Received for publication June 22, 1957.Requests for reprints should be addressed to Monroe Thomas Diamond, M.D., 175 King Street, Chappaqua, N. Y. 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SMYTH, M.D., F.A.C.P., ROGER L. BLACK, M.D., CHARLES L. CHRISTIAN, M.D., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., EDWARD C. FRANKLIN, M.D., DONALD F. HILL, M.D., F.A.C.P., JOSEPH L. HOLLANDER, M.D., F.A.C.P., HOWARD L. HOLLEY, M.D., F.A.C.P., JOHN G. MAYNE, M.D., WILLIAM M. MIKKELSEN, M.D., CHARLES L. SHORT, M.D., F.A.C.P., HUGH A. SMYTHE, M.D., F.R.C.P.(C), OTTO STEINBROCKER, M.D., HOWARD J. WEINBERGER, M.D.Normale und pathologische Anatomie der SchilddrüseTHYROID ACROPACHY 1 January 1959Volume 50, Issue 1Page: 206-213KeywordsBiopsyEdemaLesionsPulmonary functionThyroidThyroidectomy Issue Published: 1 January 1959 PDF DownloadLoading ...