tbuckley/cabot-search huggingface dataset:
Hungarians spurn private health insurance
Authors: C. Kovac
Journal: BMJ (1999)

Israel issues new rules on detainees:The facility to use chains and handcuffs to restrain security prisoners and detaineesmostly Palestinians but also Israelis-in hospital beds has been much reduced by new regulations issued by Israel's justice ministry.Under the new rules, physical restraints may be used only when other reasonable methods cannot prevent a risk of escape.The patient must be untied if chaining interferes with medical treatment
Comparison of stroke rates in patients with acute coronary syndromes and patients with acute myocardial infarction
Authors: K.W. Mahaffey, R.A. Harrington, C. Graffagnino, M.J. Alberts, M.A. Sloan, J.M. Miller, C.B. Granger, M.L. Simoons, E.J. Topol, R.M. Califf
Journal: Journal of the American College of Cardiology (1998)
Remission of Graves Disease and Iodine Intake
Authors: DONALD L. ST. GERMAIN
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 March 1988Remission of Graves Disease and Iodine IntakeDONALD L. ST. GERMAIN, M.D.DONALD L. ST. GERMAIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-3-482_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Solomon and associates (1) recently reported that the rate of remission in patients with Graves disease treated with antithyroid drugs since 1973 at their center in Washington, D.C. was approximately 50%. Although this finding is of interest, the authors' reliance on the studies of Park and associates (2) and Pennington and coworkers (3, 4) to support their speculation that this high remission rate may be due to a decrease in dietary iodine intake is inappropriate and misleading for two reasons.First, the data on iodine intake cited by the authors, and presented in the lower portion of...References1. SOLOMONEVAULBURMANWARTOFSKY BJKL. Remission rates with antithyroid drug therapy: continuing influence of iodine intake? Ann Intern Med. 1987;107:510-2. LinkGoogle Scholar2. PARKHARLANDVANDERVEENSHANKPROSKY YBJFL. Estimation of dietary iodine intake of Americans in recent years. J Am Diet Assoc. 1981;79:17-24. CrossrefMedlineGoogle Scholar3. PENNINGTONWILSONNEWELLHARLANDJOHNSONVANDERVEEN JDRBRJ. Selected minerals in foods surveys, 1974 to 1981/82. J Am Diet Assoc. 1984;84:772-80. CrossrefGoogle Scholar4. PENNINGTONYOUNGWILSONJOHNSONVANDERVEEN JBDRJ. Mineral content of foods and total diets: the Selected Minerals in Foods Survey, 1982 to 1984. J Am Diet Assoc. 1986;86:876-91. CrossrefMedlineGoogle Scholar1. PARKHARLANDVANDERVEENSHANKPROSKY YBJFL. Estimation of dietary iodine intake of Americans in recent years. J Am Diet Assoc. 1981;79:17-24. CrossrefMedlineGoogle Scholar2. PENNINGTONWILSONNEWELLHARLANDJOHNSONVANDERVEEN JDRBRJ. Selected minerals in foods surveys, 1974 to 1981/82. J Am Diet Assoc. 1984;84:772-80. CrossrefGoogle Scholar3. PENNINGTONYOUNGWILSONJOHNSONVANDERVEEN JBDRJ. Mineral content of foods and total diets: the Selected Minerals in Foods survey, 1982 to 1984. J Am Diet Assoc. 1986;86:876-91. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1988Volume 108, Issue 3Page: 482-483KeywordsDrugs ePublished: 1 December 2008 Issue Published: 1 March 1988 PDF downloadLoading ...
Lack of coordinate control of ferritin and transferrin receptor expression during rat liver regeneration
Authors: Gaetano Cairo, Lorenza Tacchini, Antonello Pietrangelo
Journal: Hepatology (1998)

Transferrin receptor (TfR) and ferritin, key proteins of cellular iron metabolism, are coordinately and divergently controlled by cytoplasmic proteins (iron regulatory proteins, IRP-1 and IRP-2) that bind to conserved mRNA motifs called iron-responsive elements (IRE). IRP, in response to specific stimuli (low iron levels, growth and stress signals) are activated and prevent TfR mRNA degradation and ferritin mRNA translation by hindering ferritin mRNA binding to polysomes. We previously found that, in regenerating liver, IRP activation was accompanied by increased TfR mRNA levels, but not by reduced ferritin expression. The basis for this unexpected behavior was investigated in the present study. Liver regeneration triggered by carbon tetrachloride (CCl4) stimulated by four- to fivefold the synthesis of both L and H ferritin chains. This increase was accompanied with a transcriptionally regulated twofold rise in the amount of ferritin mRNAs. Moreover, polysome-associated ferritin transcripts were fourfold higher in CCl4-treated animals than in control animals. Because RNA bandshift assays showed a fourfold increase in IRP-2 binding activity after CCl4 administration, activated IRP in regenerating liver seemed unable to prevent ferritin mRNAs binding to polysomes. This was confirmed by direct demonstration in the wheat germ translation system that the efficiency of IRP as a translational repressor of a mRNA bearing an IRE motif in front of a reporter transcript is impaired in CCl4-treated rats in spite of an enhanced IRE-binding capacity. In conclusion, we show for the first time that the paradigm of coordinate and opposite control of ferritin and TfR by IRP is contradicted in liver regeneration. Under these circumstances, growth-dependent signals may activate ferritin gene transcription and at the same time hamper the ability of activated IRP-2 to repress translation of ferritin mRNAs, thus preserving for growing liver cells an essential iron-storage compartment.
Cancer of the Head and Neck
Authors: Joseph W. Walike
Journal: JAMA (1982)

Head and neck cancers make up about 5% of cancers in men and about 2% of cancers in women. The overall survival of patients with head and neck cancer is 67% at five years when the disease is classified as local, but drops to 30% when disease is regional. Approximately 45,000 new cases of head and neck cancer are diagnosed each year in the United States. This volume, in my opinion, is the single best text on head and neck cancer extant. Its 32 chapters are lucidly and comprehensively written by authors with known credibility, reputation, and experience. The totality of care of the head and neck cancer patient is covered, including chapters on evaluation, preoperative and postoperative care, nutrition, anesthesia, dental considerations, nursing, and reconstruction and prosthetics. Cancer of the neck, skin, nasal cavity, paranasal sinuses, lips, oral cavity, oropharynx, nasopharynx, hypopharynx, cervical esophagus, larynx, cervical trachea, salivary glands,
Correction: Incorrect Entry in Library for Internists VIII
Authors: Joseph J. Mazza
Journal: Annals of Internal Medicine (1994)

Corrections15 July 1994Correction: Incorrect Entry in Library for Internists VIIIFREEJoseph J. MazzaJoseph J. MazzaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-2-199407150-00029 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The entry for the Manual of Medical Therapeutics was incorrect in the recently published “Library for Internists VIII” [1]. The correct entry is as follows:Manual of Medical Therapeutics. 27th edition. Edited by M. Woodley and A. Whelan. Little, Brown, Boston, 1992. 624 pages. $28.50.REFERENCE1. A library for internists VIII: recommendations from the American College of Physicians. Ann Intern Med. 1994; 120:699-720. Google Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 July 1994Volume 121, Issue 2Page: 154KeywordsLibraries ePublished: 15 August 2000 Issue Published: 15 July 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Glycoprotein IV mediates thrombospondin-dependent platelet-monocyte and platelet-U937 cell adhesion.
Authors: R L Silverstein, A S Asch, R L Nachman
Journal: Journal of Clinical Investigation (1989)

An adhesive interaction between activated platelets and mononuclear phagocytes may contribute to the role these cells play in regulating inflammation, thrombosis, and atherosclerosis. We have previously shown that this adhesive interaction is mediated by the expression of the glycoprotein thrombospondin (TSP) on the surface of activated platelets. We now show that TSP-dependent platelet-monocyte interactions are mediated by glycoprotein IV (GPIV), an intrinsic membrane protein recently identified as a cell surface TSP receptor. Monoclonal antibodies to GPIV bound to cells of the human monocytoid line U937 as assessed by flow cytometry and inhibited the binding of 125I-TSP to the cell surface by 83%. U937 cells preincubated with anti-GPIV were not rosetted by thrombin-stimulated platelets (72% inhibition compared with control anti-monocyte antibodies). In addition, when platelets were stimulated in the presence of saturating concentrations of monoclonal antibodies to GPIV, only 18% of U937 cells were rosetted (78% inhibition). Control antibodies including anti-GPIb did not inhibit rosette formation. These data suggest that TSP can cross-link platelets and monocytes via an interaction with GPIV on the surface of both cells. This molecular bridge may mediate platelet-macrophage communication in various pathophysiologic settings.
IgG antibody response to polyethylene glycol-modified adenosine deaminase in patients with adenosine deaminase deficiency.
Authors: S Chaffee, A Mary, E R Stiehm, D Girault, A Fischer, M S Hershfield
Journal: Journal of Clinical Investigation (1992)

Polyethylene glycol (PEG)-modified bovine adenosine deaminase (ADA) is used for replacement therapy of severe combined immunodeficiency disease due to inherited ADA deficiency. We monitored IgG anti-ADA antibody in 17 patients treated by intramuscular injections of PEG-ADA for 1 to greater than 5.5 yr. ELISA-detectable anti-ADA IgG appeared in 10 patients, usually between the third and eighth months of treatment. Anti-ADA levels did not correlate with trough plasma ADA activity, which averaged 1.8-5 times normal blood (erythrocyte) ADA activity, depending on dose (15-60 U/kg per wk). ELISA-detectable anti-ADA antibodies were directed primarily at bovine-specific peptide (rather than PEG-containing) epitopes. Enhanced enzyme clearance, mediated by antibody that directly inhibited native and PEG-modified bovine ADA, and native, but not PEG-modified human ADA, occurred in two patients. In one, tolerance was induced; in the second, twice weekly injections of PEG-ADA compensated for accelerated clearance. We speculate that inhibitory antibodies recognize conserved, relatively PEG-free epitope(s) encompassing the active site, and that in human, but not bovine, ADA a PEG-attachment site "shields" the active site from immune recognition. We conclude that PEG-modification largely prevents the development of high affinity, or high levels of clearing antibodies to bovine ADA, and that PEG-modified human ADA should be further investigated as a possible treatment for ADA deficiency.
GluA1 phosphorylation at serine 831 in the lateral amygdala is required for fear renewal
Authors: Sukwon Lee, Beomjong Song, Jeongyeon Kim, Kyungjoon Park, Ingie Hong, Bobae An, Sangho Song, Jiwon Lee, Sungmo Park, Jihye Kim, Dongeun Park, C Justin Lee, Kyungjin Kim, Ki Soon Shin, Richard W Tsien, Sukwoo Choi
Journal: Nature Neuroscience (2013)
OBSTRUCTIVE SLEEP APNEA AND ASTHMA CO-MORBIDITIES ARE INDEPENDENT PREDICTORS OF NEW HEART FAILURE AND ATRIAL FIBRILLATION IN PATIENTS WITH DIABETES MELLITUS AND PRESERVED EJECTION FRACTION
Authors: Sinziana Seicean, Kazuaki Negishi, Tomoko Negishi, Teerapat Yingchoncharoen, Conrad Gibby, Thomas Cook, Andreea Seicean, Xuebei An, Thomas Marwick
Journal: Journal of the American College of Cardiology (2012)
Impact of recent intravenous chemotherapy on outcome in severe sepsis and septic shock patients with hematological malignancies
Authors: Dominique M. Vandijck, Dominique D. Benoit, Pieter O. Depuydt, Fritz C. Offner, Stijn I. Blot, Anna K. Van Tilborgh, Joke Nollet, Eva Steel, Lucien A. Noens, Johan M. Decruyenaere
Journal: Intensive Care Medicine (2008)
Sleep and blood pressure.
Authors: W A Littler, A J Honour, R D Carter, P Sleight
Journal: BMJ (1975)

Direct arterial pressure was recorded continuously over 24 hours in 18 totally unrestricted people (six normotensives, four untreated hypertensives, and eight treated hypertensives). There was an almost equal fall of about 20% in both systolic and diastolic blood pressure during sleep in the three groups when compared with their waking pressures. This fall in pressure was greater than that observed previously in patients sleeping in a laboratory or hospital. Furthermore, it suggests that hypertensive subjects do not have a higher centrally-induced vasoactive component and that hypotensive drugs do not alter the pattern of blood pressure behaviour induced by sleep.
A Vote for Health Care Reform
Authors: Jonathan Oberlander
Journal: New England Journal of Medicine (2010)

Health care reform legislation has languished in political purgatory for the past 2 months, teetering between historic enactment and epic collapse. The House of Representatives and the Senate both passed health care legislation at the end of 2009. After a year of tumultuous debate, agreement seemed near on a final compromise bill that would represent both a substantial advance in health care coverage and a major political triumph for the Obama administration.But the stunning victory of Republican Scott Brown in Massachusetts' special Senate election in January sent health care reform into a tailspin. Democrats lost their 60-vote, filibuster-proof Senate . . .
Research Ethics Consultation at the National Institute of Environmental Health Sciences
Authors: David B. Resnik
Journal: The American Journal of Bioethics (2008)

Click to increase image sizeClick to decrease image size ACKNOWLEDGMENTS This research was supported by the intramural program of the National Institute of Environmental Health Sciences (NIEHS)/National Institutes of Health (NIH). It does not represent the views of the NIEHS or NIH. I am grateful to Richard Sharp for help with this manuscript.
Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study
Authors: J Foucher
Journal: Gut (2005)

<b>Background:</b> Transient elastography (FibroScan) is a new, non-invasive, rapid, and reproducible method allowing evaluation of liver fibrosis by measurement of liver stiffness. In cirrhotic patients, liver stiffness measurements range from 12.5 to 75.5 kPa. However, the clinical relevance of these values is unknown. The aim of this prospective study was to evaluate the accuracy of liver stiffness measurement for the detection of cirrhosis in patients with chronic liver disease. <b>Methods:</b> A total of 711 patients with chronic liver disease were studied. Aetiologies of chronic liver diseases were hepatitis C virus or hepatitis B virus infection, alcohol, non-alcoholic steatohepatitis, other, or a combination of the above aetiologies. Liver fibrosis was evaluated according to the METAVIR score. <b>Results:</b> Stiffness was significantly correlated with fibrosis stage (<i>r</i> = 0.73, p&lt;0.0001). Areas under the receiver operating characteristic curve (95% confidence interval) were 0.80 (0.75–0.84) for patients with significant fibrosis (F&gt;2), 0.90 (0.86–0.93) for patients with severe fibrosis (F3), and 0.96 (0.94–0.98) for patients with cirrhosis. Using a cut off value of 17.6 kPa, patients with cirrhosis were detected with a positive predictive value and a negative predictive value (NPV) of 90%. Liver stiffness was significantly correlated with clinical, biological, and morphological parameters of liver disease. With an NPV &gt;90%, the cut off values for the presence of oesophageal varices stage 2/3, cirrhosis Child-Pugh B or C, past history of ascites, hepatocellular carcinoma, and oesophageal bleeding were 27.5, 37.5, 49.1, 53.7, and 62.7 kPa, respectively. <b>Conclusion:</b> Transient elastography is a promising non-invasive method for detection of cirrhosis in patients with chronic liver disease. Its use for the follow up and management of these patients could be of great interest and should be evaluated further.
Management of breast cancer during pregnancy
Authors: Francesca Rovera, Corrado Chiappa, Alessandra Coglitore, Giorgio Maria Baratelli, Anna Fachinetti, Marina Marelli, Francesco Frattini, Matteo Lavazza, Linda Bascialla, Stefano Rausei, Luigi Boni, Adriana Dionigi Corben, Gianlorenzo Dionigi, Renzo Dionigi
Journal: International Journal of Surgery (2013)
Hensin, a new collecting duct protein involved in the in vitro plasticity of intercalated cell polarity.
Authors: J Takito, C Hikita, Q Al-Awqati
Journal: Journal of Clinical Investigation (1996)

Two forms of intercalated cells are present in kidney collecting tubules, the alpha cell has apical endocytosis, apical H+-ATPase and basolateral band 3, while beta cells have reversed polarity of these proteins and no apical endocytosis. When a beta cell line was seeded at high density, it changed into the alpha form. We previously showed that a partially purified 230 kD extracellular matrix protein of high density cells was able to retarget band 3 from apical to basolateral domains and stimulated apical endocytosis in vitro (Van Adelsberg, J., J.C. Edwards, J. Takito, B. Kiss, and Q. Al-Awqati. 1994. Cell. 76:1053-1061). We now purify this protein, which was named hensin, to near homogeneity and find that it belongs to the macrophage scavenger receptor cysteine rich (SRCR) family. An antibody, generated against a fusion protein made from a partial cDNA recognized a 230-kD protein in rabbit kidney and in the intercalated cell line. In vitro, the hensin antibody inhibited expression of apical endocytosis. Hensin was secreted in a polarized manner and bound to the basolateral membrane and extracellular matrix. Immunohistochemistry of the kidney showed that it was expressed only in collecting tubules. Double immunofluorescence with hensin and peanut lectin, H+-ATPase, or band 3 showed many patterns; most alpha-cells had hensin staining while 50% of beta-cells did not. These results suggest that hensin may also be involved in the polarity reversal of intercalated cells in vivo.
Paul Francis Heffron
Authors: T. Peck, D. Gettins
Journal: BMJ (2001)

Lecturer and senior lecturer in pharmacology Middlesex Hospital Medical School 1960-88 (b Derbyshire 1932; q Middlesex 1958; PhD), d 14 September 2001.






His didactic teaching manner perhaps reflected his devout Catholic upbringing. In some ways a private and remote personality, he nevertheless enjoyed the conviviality of the rugby club and local hostelries. An eccentric, he enjoyed snuff, and hated change and political correctness. Disapproving of the merger of the Middlesex with University College Hospital, he conducted his last lectures wearing a black armband and retired early in 1988. He moved to Ireland and restored an isolated croft at Pontoon, County Mayo. Here he enjoyed the trees, the Times crossword, and, above all, the company and affection of a group of equally colourful friends. Sadly his liver failed to compensate for his chosen lifestyle. He was unmarried.
Serum hepcidin level is not an independent surrogate biomarker of disease activity or of radiographic progression in rheumatoid arthritis: results from the ESPOIR cohort
Authors: Jérémie Sellam, Salma Kotti, Soraya Fellahi, Jean-Philippe Bastard, Magali Meyer, Frédéric Lioté, Olivier Meyer, Tabassome Simon, Jacqueline Capeau, Francis Berenbaum
Journal: Annals of the Rheumatic Diseases (2012)

Hepcidin is an interleukin-6 induced peptide hormone involved in iron metabolism and inflammation.1 Serum hepcidin level may distinguish anaemia due to chronic inflammation and/or iron deficiency in rheumatoid arthritis (RA) patients.2 Furthermore, some studies have suggested that serum hepcidin could reflect disease activity raising its measurement as a new surrogate biomarker of RA.3–6 These studies have several drawbacks (unreliable pro-hormone quantification, small number of patients).7 ,8 Therefore, we assessed the serum level of the mature form of hepcidin by ELISA (Bachem, St Helens, Merseyside, UK) in 791 individuals from the French cohort of early arthritis (ESPOIR) including 632 patients with RA fulfilling the American College of Rheumatology (ACR) - European League Against Rheumatism (EULAR) criteria at inclusion and 159 with undifferentiated arthritis in order to address whether hepcidin accurately reflects RA features, disease activity or radiographic disease progression.9 ,10

Beyond expected differences between RA and undifferentiated arthritis, serum hepcidin level was higher in RA (table 1). Hepcidin level was positively correlated with disease activity score in 28 joints (DAS28)-erythrocyte sedimentation rate at inclusion. However, the only variable used in calculating DAS28 that was correlated …
Responses of pulmonary allograft and cheek pouch arterioles in the hamster to alterations in extravascular pressure in different oxygen environments.
Authors: M J Davis, J P Gilmore, W L Joyner
Journal: Circulation Research (1981)

The responses to changes in transmural pressure were investigated in pulmonary allograft and cheek pouch arterioles in two oxygen environments. Neonatal hamster lung tissue was transplanted into adult hamster cheek pouches. After vascularization (8-10 days), pulmonary and cheek pouch vessels were observed by intravital microscopy in hamsters anesthetized with pentobarbital. By gassing the suffusion solution (bicarbonate-buffered Ringer's) (pH 7.4 at 35-37 degrees C) with either low oxygen (95% N2/5% CO2) or high oxygen (75% N2/5% CO2/20% O2) and after sealing the top of the chamber, extravascular pressure was altered by varying the fluid volume of the closed chamber. Changes in arteriolar diameters in response to positive and negative square-wave pressure pulses were quantified using a video micrometer and close-circuit TV system. Pulmonary arterioles showed a passive dilation or constriction in response to increases or decreases in transmural pressure (+/-20 mm Hg). These responses were not altered either by changes in PO2 or nitroprusside. In contrast, cheek pouch arterioles showed myogenic responses by constricting when transmural pressure was increased and vice versa. These responses were potentiated at high PO2 and abolished with nitroprusside. It is concluded that a myogenic response is dominant in cheek pouch arterioles but not in pulmonary arterioles under these conditions. These latter observations are consistent with results obtained from isolated, intact lung.
Assessment of coronary artery blood flow velocity using breath-hold phase contrast MR angiography in patients with acute myocardial infarction
Authors: A. Furber, F. Lothimonnier, J.J. Lojoune, P. L'hoste, A. Tadei, P. Jallet, C. Caron-Poitreau, P. Goslin
Journal: Journal of the American College of Cardiology (1998)
COMPLICATIONS OF CHLORPROMAZINE THERAPY
Authors: IRVIN M. COHEN
Journal: American Journal of Psychiatry (1956)

1. Chlorpromazine has many undesirable effects, most of which are transient and of relatively minor clinical significance. 2. Complications of greater severity occur in a significant number of cases but generally resolve rapidly and without residuals. 3. Four categories of complications are distinguishable: direct or indirect action on various levels of the nervous System, allergic-type reactions, responses of indefinite origin, and indirect effects of drug action. 4. Despite its numerous undesirable effects chlorpromazine is clinically a relatively safe drug.