tbuckley/cabot-search huggingface dataset:
Abstract 2202: Identification of CDH1 mutations in patients with lobular carcinoma with and without a family history of gastric cancer
Authors: Allyson L. Valente, Rachel E. Ellsworth, Susan Lubert, Charvonne Holliday, Craig D. Shriver
Journal: Cancer Research (2011)

Abstract Background: The E-cadherin (CDH1) gene is involved in cell adhesion and maintenance of tissue architecture. Loss of expression of CDH1 has been found in both invasive lobular carcinoma (ILCA) of the breast as well as hereditary diffuse gastric cancer (HDGC). While mutations in CDH1 have been found in patients with hereditary diffuse gastric cancer, less is known about the role of CDH1 mutations in patients with breast cancer, thus mutation status was determined in a breast cancer cohort with and without family histories of gastric cancer. Methods: The Clinical Breast Care Project database was queried to identify all patients with ILCA with or without a family history of gastric or stomach cancer as well as those with non-lobular invasive cancer with a family history of gastric or stomach cancer. Genomic DNA was isolated from peripheral blood samples. DNA variants were detected for each exon using high-resolution melting technology and the underlying change identified by direct sequencing. Results: Of the 72 patients with ILCA, five had a first degree relative with stomach cancer; 14 patients with non-lobular invasive cancer (12 IDCA, one mixed lobular and ductal, and one tubular) had first degree relatives with stomach or gastric cancer. Three mutations previously associated with gastric cancer were identified: A617T and V832M were identified in a patient with ILCA with no history of gastric cancer and in a patient with IDCA with a family history of gastric cancer, respectively, while one patient with ILCA and no family history harbored the splice site mutation 1137G-T. Three novel variants were also identified: G879S, in a patient with ILCA and no family history, P825Q in a patient with mixed lobular and ductal features with a family history of stomach cancer and L230F in a patient with IDCA and a family history of stomach cancer. Conclusions: The frequency of CDH1 mutations in this patient population was low (∼7%) and were split between patients with ILCA and no family history of gastric cancer and those with non-lobular cancers and at least one family member with gastric or stomach cancer. Identification of known mutations in patients with non-lobular carcinomas suggests that while these specific CDH1 mutations are associated with increased risk of hereditary diffuse gastric cancer, they do not confer increased risk for lobular cancer. In those patients with ILCA, the low frequency of germline mutations in CDH1 suggests alternate methods, such as epigenetic modification or miRNA silencing, may be driving the suppression of expression of E-cadherin and the development of ILCA. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2202. doi:10.1158/1538-7445.AM2011-2202
Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation.
Authors: M Adams, C T Montague, J B Prins, J C Holder, S A Smith, L Sanders, J E Digby, C P Sewter, M A Lazar, V K Chatterjee, S O'Rahilly
Journal: Journal of Clinical Investigation (1997)

Activation of peroxisome proliferator-activated receptor (PPAR) gamma, a nuclear receptor highly expressed in adipocytes, induces the differentiation of murine preadipocyte cell lines. Recently, thiazolidinediones (TZDs), a novel class of insulin-sensitizing compounds effective in the treatment of non-insulin-dependent diabetes mellitus (NIDDM) have been shown to bind to PPARgamma with high affinity. We have examined the effects of these compounds on the differentiation of human preadipocytes derived from subcutaneous (SC) and omental (Om) fat. Assessed by lipid accumulation, glycerol 3-phosphate dehydrogenase activity, and mRNA levels, subcultured preadipocytes isolated from either SC or Om depots did not differentiate in defined serum-free medium. Addition of TZDs (BRL49653 or troglitazone) or 15-deoxyDelta12,14prostaglandin J2 (a natural PPARgamma ligand) enhanced markedly the differentiation of preadipocytes from SC sites, assessed by all three criteria. The rank order of potency of these agents in inducing differentiation matched their ability to activate transcription via human PPARgamma. In contrast, preadipocytes from Om sites in the same individuals were refractory to TZDs, although PPARgamma was expressed at similar levels in both depots. The mechanism of this depot-specific TZD response is unknown. However, given the association between Om adiposity and NIDDM, the site-specific responsiveness of human preadipocytes to TZDs may be involved in the beneficial effects of these compounds on in vivo insulin sensitivity.
A novel hybrid CFH/CFHR3 gene generated by a microhomology-mediated deletion in familial atypical hemolytic uremic syndrome
Authors: Nigel J. Francis, Bairbre McNicholas, Atif Awan, Mary Waldron, Donal Reddan, Denise Sadlier, David Kavanagh, Lisa Strain, Kevin J. Marchbank, Claire L. Harris, Timothy H. J. Goodship
Journal: Blood (2011)
Abstract IA23: The BRCA1 tumor suppressor network
Authors: Roger A. Greenberg
Journal: Cancer Research (2014)

Abstract BRCA1 is an essential component of multiple distinct protein complexes that are dedicated to DNA damage recognition and repair. Germline heterozygous mutations to genes encoding multiple BRCA associated proteins result in cancer susceptibility, while biallelic mutations lead to developmental abnormalities, cancer predisposition, and systemic hypersensitivity to chemotherapy. BRCA1 associates with the RAP80 complex to recognize lysine63-linked ubiquitin chains at DNA damage sites. Three members of the RAP80 complex are mutated in hereditary breast cancer, implicating ubiquitin recognition as a bona fide component of BRCA1 dependent tumor suppression. This presentation will describe in vivo interactions between BRCA1 associated DNA damage site ubiquitin recognition and other protein complexes that are dedicated to homologous recombination mediated DNA repair to S-phase. Relevance to cancer etiology and response to therapy will be discussed. Citation Format: Roger A. Greenberg. The BRCA1 tumor suppressor network. [abstract]. In: Proceedings of the AACR Special Conference: Cancer Susceptibility and Cancer Susceptibility Syndromes; Jan 29-Feb 1, 2014; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(23 Suppl):Abstract nr IA23. doi:10.1158/1538-7445.CANSUSC14-IA23
Improving the Antitumor Activity of Squalenoyl‐Paclitaxel Conjugate Nanoassemblies by Manipulating the Linker between Paclitaxel and Squalene
Authors: Joachim Caron, Andrei Maksimenko, Séverine Wack, Elise Lepeltier, Claudie Bourgaux, Estelle Morvan, Karine Leblanc, Patrick Couvreur, Didier Desmaële
Journal: Advanced Healthcare Materials (2012)

A series of new lipid prodrugs of paclitaxel, which can be formulated as nanoassemblies, are described. These prodrugs which are designed to overcome the limitations due to the systemic toxicity and low water solubility of paclitaxel consist of a squalene chain bound to the 2'-OH of paclitaxel through a 1,4-cis,cis-dienic linker. This design allows the squalene-conjugates to self-assemble as nanoparticular systems while preserving an efficient release of the free drug, thanks to the dienic spacer. The size, steric hindrance, and functional groups of the spacer have been modulated. All these prodrugs self-assemble into nanosized aggregates in aqueous solution as characterized by dynamic light scattering and transmission electron microscopy and appear stable in water for several days as determined by particle size measurement. In vitro biological assessment shows that these squalenoyl-paclitaxel nanoparticles display notable cytotoxicity on several tumor cell lines including A549 lung cell line, colon cell line HT-29, or KB 3.1 nasopharyngeal epidermoid cell line. The cis,cis-squalenyl-deca-5,8-dienoate prodrug show improved activity over simple 2'-squalenoyl-paclitaxel prodrug highlighting the favourable effect of the dienic linker. The antitumor efficacy of the nanoassemblies constructed with the more active prodrugs has been investigated on human lung (A549) carcinoma xenograft model in mice. The prodrug bearing the cis,cis-deca-5,8-dienoyl linker shows comparable antitumor efficacy to the parent drug, but reveals a much lower subacute toxicity as seen in body weight loss. Thus, nanoparticles with the incorporated squalenoyl paclitaxel prodrug may prove useful for replacement of the toxic Cremophor EL.
Alterations in the regional adrenergic system in experimental left ventricular hypertrophy
Authors: P. M Scholz, M. E Upsher, D. Eliades, J. Kedem, H. R Weiss
Journal: Cardiovascular Research (1990)

Journal Article Alterations in the regional β adrenergic system in experimental left ventricular hypertrophy Get access Peter M Scholz, Peter M Scholz Search for other works by this author on: Oxford Academic PubMed Google Scholar Mary E Upsher, Mary E Upsher Search for other works by this author on: Oxford Academic PubMed Google Scholar Diane Eliades, Diane Eliades Search for other works by this author on: Oxford Academic PubMed Google Scholar Joseph Kedem, Joseph Kedem Search for other works by this author on: Oxford Academic PubMed Google Scholar Harvey R Weiss Harvey R Weiss Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 24, Issue 1, January 1990, Pages 65–71, https://doi.org/10.1093/cvr/24.1.65 Published: 01 January 1990 Article history Received: 05 June 1989 Accepted: 31 August 1989 Published: 01 January 1990
Regional In Vivo and In Vitro Characterization of Autonomic Innervation in Cardiomyopathic Human Heart
Authors: Martin Ungerer, Franz Hartmann, Mislav Karoglan, Andreas Chlistalla, Sibylle Ziegler, Gert Richardt, Matthias Overbeck, Hans Meisner, Albert Schömig, Markus Schwaiger
Journal: Circulation (1998)

Background —In contrast to healthy volunteers, regional differences of cardiac autonomic innervation have been described through the use of C 11 -hydroxyephedrine positron emission tomography (HED-PET) in the left ventricles of patients with dilated cardiomyopathy. The goal of the present study was to correlate HED-PET images with biochemical analysis of tissue samples. Methods and Results —To assess the significance of altered HED uptake, we used HED-PET to examine eight patients with dilated cardiomyopathy before heart transplantation. After explantation, we measured the density and affinity of uptake 1 ( 3 H-mazindol binding) and tissue norepinephrine content as markers of presynaptic function, and we determined β-receptor density and affinity ( 3 H-CGP 12177 binding) in the corresponding areas of the same patients. The density of uptake 1 and norepinephrine content showed marked regional variation, with highest values in the anterior septal wall and lowest in inferoapical and apical areas. Both parameters were closely correlated ( r =.65, P =.05). Similarly, uptake 1 density or norepinephrine content and HED retention (PET) showed clear correlations ( r =.63 and .60, respectively). Uptake 1 affinities did not vary significantly and were not correlated to the other parameters. β-Adrenergic receptor density showed some, albeit less pronounced, regional variation and was weakly correlated to uptake 1 density and local HED retention ( r =.38 and .31, respectively). Conclusions —Uptake 1 density and tissue norepinephrine content showed marked regional variation in cardiomyopathic left ventricles. HED-PET is significantly correlated to the density but not the affinity of uptake 1 sites in the human heart, suggesting either loss of neurons or downregulation of uptake 1 in dilated cardiomyopathy. HED-PET is a valuable marker for alterations of the presynaptic sympathoadrenergic system in humans.
Long-Acting β-Agonists With vs Without Inhaled Corticosteroids for COPD
Authors: Samy Suissa, Pierre Ernst
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Locking a Leukocyte Integrin with Statins
Authors: P S Frenette
Journal: New England Journal of Medicine (2001)

The first of the hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (collectively referred to as “statins”) was identified in 1976.1 This enzyme was an ideal target for treating hypercholesterolemia, since it catalyzes the conversion of HMG-CoA to mevalonate, a limiting step in cholesterol synthesis. Today, statins are the most powerful hypolipidemic drugs available and are widely prescribed throughout the world.Because lipid intermediates of cholesterol synthesis (isoprenoids) allow the attachment to the cell membrane of signaling proteins involved in various functions, statins have other biologic effects.2 They can stimulate bone formation, alter the function of endothelial cells, induce apoptosis of smooth-muscle . . .
Morphology and Long-term Changes of Choroidal Vascular Structure in Highly Myopic Eyes with and without Posterior Staphyloma
Authors: Muka Moriyama, Kyoko Ohno-Matsui, Soh Futagami, Takeshi Yoshida, Kengo Hayashi, Noriaki Shimada, Ariko Kojima, Takashi Tokoro, Manabu Mochizuki
Journal: Ophthalmology (2007)
Systemic lupus erythematosus in association with ulcerative colitis: related autoimmune diseases
Authors: H.P. STEVENS, L.S. OSTLERE, M.H.A. RUSTIN
Journal: British Journal of Dermatology (1994)

Journal Article Systemic lupus erythematosus in association with ulcerative colitis: related autoimmune diseases Get access H.P. STEVENS, H.P. STEVENS Department of Dermatology, Royal Free Hospital and School of Medicine, Pond Street, London NW3 2QG, U.K. Search for other works by this author on: Oxford Academic Google Scholar L.S. OSTLERE, L.S. OSTLERE Department of Dermatology, Royal Free Hospital and School of Medicine, Pond Street, London NW3 2QG, U.K. Search for other works by this author on: Oxford Academic Google Scholar M.H.A. RUSTIN M.H.A. RUSTIN Department of Dermatology, Royal Free Hospital and School of Medicine, Pond Street, London NW3 2QG, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 130, Issue 3, 1 March 1994, Pages 385–389, https://doi.org/10.1111/j.1365-2133.1994.tb02938.x Published: 01 March 1994 Article history Accepted: 19 July 1993 Published: 01 March 1994
A cleavable cytolysin–neuropeptide Y bioconjugate enables specific drug delivery and demonstrates intracellular mode of action
Authors: Verena M. Ahrens, Katja B. Kostelnik, Robert Rennert, David Böhme, Stefan Kalkhof, David Kosel, Lutz Weber, Martin von Bergen, Annette G. Beck-Sickinger
Journal: Journal of Controlled Release (2015)
MYCOSIS OF THE BOVINE FETAL MEMBRANES DUE TO A MOULD OF THE GENUS MUCOR
Authors: Theobald Smith
Journal: The Journal of Experimental Medicine (1920)

A mucor, closely resembling Lichtheim's Mucor rhizopodiformis, was isolated from the diseased chorion of a cow and from the lungs and digestive tract of the fetus. No other microorganisms were detected. The mucor was demonstrated in teased preparations from the fresh cotyledons as well as in sections of tissues suitably hardened. It produced focal lesions in rabbits following the intravenous injection of spores. The condition of the amniotic fluid and the contents of the rumen of the fetus justify the inference that premature expulsion was impending.
The Surgical Treatment of Urinary Incontinence
Authors: Marshall K. Bartlett
Journal: New England Journal of Medicine (1947)

THE subject of exertional incontinence in women — or "stress incontinence," as it is frequently called — has stimulated the imagination of the medical profession for many years. Numerous operative procedures have been devised for the cure of this condition, but as yet no entirely satisfactory technic is available.This study was stimulated by the work of Dr. William T. Kennedy,1 2 3 of New York. His results were so far superior to those previously attained that they could not fail to arouse interest.Up to the time this study was undertaken, the usual procedure employed at the Massachusetts General Hospital for . . .
TYPES OF NEUROSYPHILIS IN RELATION TO TREATMENT
Authors: HENRY A. BUNKER
Journal: JAMA (1926)

It is a well established fact that syphilis of the nervous system varies in the widest possible manner in its amenability to treatment. At one extreme we have those cases of neurosyphilis in which the spinal fluid becomes completely and permanently negative after a few intravenous injections of arsphenamine, and sometimes even spontaneously without treatment; while at the other end of the scale stand those cases which prove intractable to all ordinary methods of antisyphilitic treatment, and which in general develop sooner or later into outspoken cases of tabes or general paralysis. Now it is not too much to say that some years ago—before the introduction of intraspinal therapy and its modifications in the form of intracisternal and intraventricular injections,<sup>1</sup>and especially tryparsamide<sup>2</sup>and the malaria treatment<sup>3</sup>—it was not of especial practical importance to discriminate between these two broadly divisible types of neurosyphilis; for the vast
Vascular ectasia of the whole intestine as a cause of recurrent gastrointestinal bleeding after high-dose chemotherapy
Authors: R. Schmidmaier, I. Bittmann, M. Götzberger, C. Straka, G. Meinhardt, A. Eigler
Journal: Endoscopy (2006)

We present the first case in the literature of vascular ectasia of the whole intestine as a cause of recurrent and profuse gastrointestinal bleeding in a patient with relapsing Hodgkin's disease. The 17-year-old patient experienced early relapse of his Hodgkin's disease after first-line chemotherapy. Salvage chemotherapy was followed by high-dose chemotherapy and autologous stem cell transplantation. Complete remission was achieved after another relapse by means of a second transplant. The patient presented with profuse gastrointestinal bleeding 5 months later, however. Gastric antral vascular ectasia following hematopoietic stem cell transplantation was diagnosed by endoscopy, with histological confirmation. Similar lesions were found in the duodenum, the ileum, and throughout the entire colon. In conclusion, vascular ectasia of the whole intestine should be considered as cause of acute gastrointestinal bleeding after stem cell transplantation. Physicians should be aware of this complication because its onset is typically delayed. Importantly, this disease is not limited to patients who have undergone allogeneic transplantation, but can also occur after autologous transplantation.
The Role and Future of Endoscopic Imaging Systems
Authors: None Schurr, None Kunert, None Arezzo, None Buess
Journal: Endoscopy (1999)

Visual perception is the main sensory input from the environment in most situations of daily life. It is the only sensory input from the operating field in endoscopic surgery, and thus the qualities of the optical imaging system have a considerable impact on the course of the surgical intervention. Significant improvements have been made recently in various fields of science and engineering, influencing endoscopic imaging systems in experimental and clinical use. Among these are technologies that improve the endoscope itself in terms of providing new visual features, such as fogging prevention and plastic images, using new illumination techniques. Other developments concern the improvement of image resolution and color fidelity through new charge-coupled device (CCD) sensors or alternative techniques for image creation. Finally, the combination of endoscopic technologies with robotics provides for intuitive and more efficient direction of the line of sight.
Egg oral immunotherapy in nonanaphylactic children with egg allergy
Authors: Ariana D. Buchanan, Todd D. Green, Stacie M. Jones, Amy M. Scurlock, Lynn Christie, Karen A. Althage, Pamela H. Steele, Laurent Pons, Rick M. Helm, Laurie A. Lee, A. Wesley Burks
Journal: Journal of Allergy and Clinical Immunology (2006)
TOXICITY AS AN ETIOLOGY OF NERVOUS DISEASES.
Authors: ALBERT E. STERNE
Journal: JAMA (1895)

Of all branches of medicine, that represented by diseases of the nervous system has perhaps been least influenced by the science of bacteriology. In a minor way it has felt the effect of microbic theories, but until now, so far as my knowledge extends, no attempt has been made to explain more rationally upon this basis some of the vexed questions of the etiology of many nervous affections. I shall undertake to bring forward a newer origin of many diseases of the nervous system. In these days of scientific medicine our profession rightfully demands proofs. I am aware that I have little incontestable proof in support of this theory to offer at the present time. Nevertheless, I think considerable evidence for the toxic origin of many affections of which the etiology has long been a source of doubt will be shown. In speaking of the toxic origin of nervous diseases
Anterior ischaemic optic neuropathy in the acquired immune deficiency syndrome.
Authors: M J Brack, P G Cleland, R I Owen, E D Allen
Journal: BMJ (1987)

Une observation: homme de 45 ans, ayant sejourne en Zambie pendant plusieurs annees, eu des rapports sexuels avec de nombreuses femmes et contracte plusieurs maladies. Il avait recu aussi une transfusion sanguine. Il presente en 1986 des troubles de la vision de l'œil droit, une perte de la memoire des evenements recents et des cephalees. Diagnostic de neuropathie optique ischemique anterieure liee a une encephalite subaigue due au SIDA
Alopecia in Uver transplant recipients
Authors: G.E. Sale
Journal: British Journal of Dermatology (1997)

Journal Article Alopecia in Uver transplant recipients Get access G.E. Sale G.E. Sale Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, Washington 98104‐2092, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 136, Issue 4, 1 April 1997, Page 635, https://doi.org/10.1111/j.1365-2133.1997.tb02165.x Published: 01 April 1997