Prednisone Therapy of Post-Transfusion Purpura
Authors: LAURIE J. WEISBERG
Journal: Annals of Internal Medicine (1984)

Brief Reports1 January 1984Prednisone Therapy of Post-Transfusion PurpuraLAURIE J. WEISBERG, M.D., CHARLES A. LINKER, M.D.LAURIE J. WEISBERG, M.D.Search for more papers by this author, CHARLES A. LINKER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-1-76 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPost-transfusion purpura is a rare syndrome characterized by sudden, severe thrombocytopenia occurring 1 week after a blood transfusion (1). Although most patients have had mild bleeding and recovered spontaneously, some have died from bleeding complications (2). Plasmapheresis and exchange transfusion have resulted in clinical improvement in some cases (3), but other less invasive treatments have failed to produce clear-cut responses (4). We report the case of a patient with post-transfusion purpura in whom prednisone therapy led to a rapid, complete response.A 59-year-old woman with a history of transfusions and three pregnancies had revision of a hip replacement. There was...References1. SHULMANASTERLEITNERHILLER NRAM. Immunoreactions involvng platelets: V. Post-transfusion purpura due to a complement-fixing antibody against a genetically controlled platelet antigen: a proposed mechanism for thrombocytopenia and its relevance in "autoimmunity." J Clin Invest. 1961;40:1597-620. CrossrefMedlineGoogle Scholar2. GERSTNERSMITHDAVISCIMOASTER JMKPR. Post-transfusion purpura: therapeutic failure of PlA1-negative platelet transfusion. Am J Hematol. 1979;6:71-5. CrossrefMedlineGoogle Scholar3. ABRAMSONEISENBERGASTER NPR. Post-transfusion purpura: immunologic aspects and therapy. N Engl J Med. 1974;291:1163-6. CrossrefMedlineGoogle Scholar4. SHULMANJORDAN NJ. Platelet immunology. In: COLMAN RW, HIRSH J, MARDER VJ, SALZMAN EW, eds. Hemostasis and Thrombosis. Philadelphia: J.B. Lippincott Company; 1982: 290-8. Google Scholar5. LIZAKGRUMET GF. A new micromethod for the in vitro detection of antiplatelet antibodies: C-FDA thrombocytotoxicity. Hum Immunol. 1980;1:87-96. CrossrefMedlineGoogle Scholar6. LEIKOLAPERKINS JH. Red cell antibodies and low ionic strength: a study with enzyme-linked antiglobulin test. Transfusion. 1980;20:224-8. CrossrefMedlineGoogle Scholar7. MORRISONMOLLISON FP. Post-transfusion purpura. N Engl J Med. 1966;275:243-8. CrossrefMedlineGoogle Scholar8. KICKLERNESSBELL TPW. Ability of PLA-1 negative platelets to acquire PLA-1 specificity from plasma obtained from stored blood: a proposed mechanism to explain the autologous destruction of platelets in post transfusion thrombocytopenia. Blood. 1982;60 (suppl 1):179a. Google Scholar9. REZNIKOFF-ETIEVANTDANGULOBET MCR. HLA-B8 antigen and anti-PLA1 allo-immunization. Tissue Antigens. 1981;18:66-8. CrossrefMedlineGoogle Scholar10. SLICHTER S. Post-transfusion purpura: response to steroids and association with red blood cell and lymphocytotoxic antibodies. Br J Haematol. 1982;50:599-605. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of California, San Francisco San Francisco, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTransfusion ReactionsPost-Transfusion Purpura Following Cardiac SurgeryImmunological Complications of Blood TransfusionImmunological complications of blood transfusionEfficacy of HPA-1a (PlA1)-negative platelets in a patient with post-transfusion purpuraA second case of post-transfusion purpura caused by HPA-5a antibodies: successful treatment with intravenous immunoglobulinTherapeutic apheresis in hematological and oncological diseasesPosttransfusion purpura: Two unusual cases and a literature reviewPost-transfusion purpura: a survey of 12 Danish cases with special reference to immunoglobulin G subclasses of the platelet antibodiesThrombocytopeniaManagement of hematological disorders and cancerPost-transfusion purpura as the main manifestation of a trilineal transfusion reaction, responsive to steroids: flow-cytometric investigation of granulocyte and platelet antibodiesHematologic Support of the Patient with MalignancyHigh-dose IgG for post-transfusion purpura-revisitedPOST-TRANSFUSION PURPURAPost-transfusion purpura: A report of five patients and a review of the pathogenesis and managementRelapsing post-transfusion purpura. A preventable disease 1 January 1984Volume 100, Issue 1Page: 76-77KeywordsBlood banksBlood transfusionHemorrhageHipHuman leukocyte antigenPregnancy Issue Published: 1 January 1984 PDF DownloadLoading ...