tbuckley/cabot-search huggingface dataset:
Pyloric-gland adenoma of the stomach: case report of a rare tumor successfully treated with endoscopic submucosal dissection
Authors: D. Golger, A. Probst, T. Wagner, H. Messmann
Journal: Endoscopy (2008)

A 79-year-old woman underwent gastroduodenoscopy because of anemia. A gastric polyp was diagnosed as an incidental finding. The polyp was located in the gastric antrum and measured about 2 cm ([Fig. 1]). It was of a hard consistency, with bridging folds and a positive lifting sign. The overlying mucosa was intact. Using the narrow-band imaging technique the tumor was seen to have asteroid-shaped mucosal pits and no vascular abnormalities suggestive of malignancy ([Fig. 2]). Biopsies were taken and showed chronic, Helicobacter-pylori-negative gastritis. Endoscopic ultrasonography was performed and showed an echogenic nodule within the submucosa ([Fig. 3]). For diagnostic and therapeutic purposes we decided to remove the tumor and performed an endoscopic submucosal dissection ([Fig. 4]). The histological examination revealed an adenoma of the pyloric-gland type. There was no evidence of malignant transformation and the resection was complete ([Fig. 5]).
THE TREATMENT OF TRICHIASIS BY MEANS OF THE X RAYS
Authors: C. Kempster
Journal: BMJ (1915)

effect, not onily oln tlhe temuperature but also on the whole clinical picture.Tlle effect of salicylic acid in varyinig strengatlhs was tested on the organisms whlichl attack the ihtestinial tract as well as those responsible for inflammIlationl, septicaemia, and tetanus.The ordinary agar was found to take up only to 0.5 per cent.; higher strengths than tllis caused liquefaction of the nedia--the very process whichl is useful in removing slouahs wlhen the powder is freely dusted on the wound.The strerngtlhs of the agar tubes were arranged from 0.5 down to 0.025 per cent. of salicylic acid.In these strengtlhs it had no effect on the B. colt commt&nnis nor on the B. pyocyaneus In 0.5 per cent.the B. plyocyaneus did not prodtuce the typical greenish-blue tint in the media, but a faint reddislh-brown colour; below 0.5 per cent.the colour was unclhanged.B. dysenteriace (Shiga), B. typhossts, Staplylococcns atlrens, and B. sitbtilis were all absolutely prevented g,rowina by tlhe addition of salicylic acid to tlle media in strengtths of 0.1, 0.2,0.3, 0.4, and 0.5 per cent.They grew at 0.05 and 0.025 per cent.
Do CLL B cells correspond to naive or memory B-lymphocytes? Evidence for an active Ig switch unrelated to phenotype expression and Ig mutational pattern in B-CLL cells
Authors: P Oppezzo, C Magnac, S Bianchi, F Vuillier, A Tiscornia, G Dumas, B Payelle-Brogard, F Ajchenbaum-Cymbalista, G Dighiero, O Pritsch
Journal: Leukemia (2002)
D6-04: Increased numbers of endothelial progenitor cells in peripheral blood and tumour specimens in non small cell lung cancer patients. A methodological challenge and ongoing debate on the clinical relevance
Authors: Andreas Pircher, Sergej Skvortsov, Margit Dlaska, G Untergasser, Christian M. Kaehler, Thomas Schmid, Wolfgang Hilbe
Journal: Journal of Thoracic Oncology (2007)
NHS needs to assess risks of splitting its budget between several agencies, says think tank
Authors: G. Iacobucci
Journal: BMJ (2013)

Government changes to the way NHS funding is allocated in England risk undermining the drive for greater integration in the health service and should be thoroughly assessed, health policy experts have warned.

Changes that the government has made to NHS resource allocations for 2013-14 have split budgets previously distributed in their entirety to primary care trusts between many different agencies. In a new report this week the health policy think tank the King’s Fund said that this would fragment the system and “make it more difficult to commission integrated forms of provision.”1

The changes, part of the Health and Social Care Act 2012, will see financial allocations from the Department of Health split between local clinical commissioning groups, which will hold …
Changes in collagenases and TGF-β; precede structural alterations in a model of chronic renal fibrosis
Authors: Wa Mo, Carolyn Brecklin, Sandra L. Garber, Ruo H. Song, Alfredo A. Pegoraro, Julienne Au, Jose A.L. Arruda, George Dunea, Ashok K. Singh
Journal: Kidney International (1999)
Black Women's Risk for HIV: Rough Living
Authors: Haig Donabedian
Journal: Annals of Internal Medicine (2009)

Medical Writings: Book Notes6 January 2009Black Women's Risk for HIV: Rough LivingHaig Donabedian, MDHaig Donabedian, MDFrom the University of Toledo College of Medicine, Toledo, Ohio.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-1-200901060-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Gentry QM. 282 pages. Philadelphia: Haworth Pr; 2007. $54.95. ISBN 9780789031709. Order at www.haworthpress.com.Field of medicine: HIV care and primary care of inner-city populations.Format: Hardcover and softcover book.Audience: Those caring for and providing services to impoverished black women.Purpose: To understand why inner-city black women are disproportionately at risk for HIV infection and how HIV affects their daily lives.Content: The book is an ethnographic study by a black woman of black women living in an impoverished neighborhood of Atlanta known as “The Rough.” It is derived from the author's doctoral thesis in sociology and from her ... Author, Article, and Disclosure InformationAffiliations: From the University of Toledo College of Medicine, Toledo, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 January 2009Volume 150, Issue 1Page: 64KeywordsChildrenDrugsHIVHIV infectionsHeartPopulation statisticsSoftware tools ePublished: 6 January 2009 Issue Published: 6 January 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Association between hyperglycemia and the no-reflow phenomenon inpatients with acute myocardial infarction
Authors: Katsuomi Iwakura, Hiroshi Ito, Masashi Ikushima, Shigeo Kawano, Atsushi Okamura, Katsuaki Asano, Tadashi Kuroda, Koji Tanaka, Tohru Masuyama, Masatsugu Hori, Kenshi Fujii
Journal: Journal of the American College of Cardiology (2002)
Primary culture of adult rat hepatocytes after 48-hour preservation of the liver with cold UW solution
Authors: Claire Guyomard, Christophe Chesne, Bernard Meunier, Alain Fautrel, Catherine Clerc, Fabrice Morel, Maryvonne Rissel, Jean-Pierre Campion, André Guillouzo
Journal: Hepatology (1990)

Rat livers were perfused and stored for 48 hr in cold University of Wisconsin solution before dissociation by the two-step collagenase method. At that time, glycogen content was significantly reduced, but no obvious changes in albumin, beta-actin and aldolase B mRNAs and in glutathione levels were observed. Enzymatic perfusion yielded 280 +/- 30 x 10(6) viable hepatocytes vs. 520 +/- 40 x 10(6) viable hepatocytes from unstored organs. Cell viability determined by trypan blue exclusion was 74% and 90%, respectively. Hepatocytes from University of Wisconsin-preserved livers had a 29% reduced adenosine triphosphate content, but glutathione levels did not significantly differ from those found in unstored cells. When put into culture, hepatocytes formed typical monolayers of granular epithelial cells and did not exhibit alteration of their fine structure when compared with cells from unstored organs. After 24 and 48 hr, they showed variations in cytochrome P-450 content and ethoxyresorufin O-deethylase activity similar to those observed with unstored cells. By contrast, overall protein synthesis and albumin secretion rate were 40% and 30% lower, respectively. Hepatocytes from University of Wisconsin-preserved organs could be cryopreserved and further cultured as unstored cells. The University of Wisconsin solution was also used to preserve isolated hepatocytes. Viability of freshly isolated hepatocytes was decreased by only 10% after 48 hr of hypothermic liver storage when assayed by intracellular lactate dehydrogenase content. However, after 4 hr of storage, in contrast with hepatocytes preserved in L15 Leibovitz medium, the cells attached poorly to plastic and exhibited morphological alterations.(ABSTRACT TRUNCATED AT 250 WORDS)
Successful treatment of therapy-resistant metastatic Crohn's disease with infliximab
Authors: A. Rispo, G. Lembo, L. Insabato, A. Cozzolino, G. Pesce, F. Castiglione
Journal: British Journal of Dermatology (2004)

Sir, Metastatic Crohn's disease is a rare dermatological manifestation of Crohn's disease in which there is prominent granulomatous inflammation involving a skin area that can be distant from the affected gastrointestinal tract.1 The cutaneous lesions (papules that may enlarge, ulcerate and/or drain pus) can occur at various locations, although they are most frequent in the perineal region, particularly in patients with fistulizing perianal disease or previous proctectomy.2 In contrast to other cutaneous manifestations of Crohn's disease, such as erythema nodosum or pyoderma gangrenosum, metastatic Crohn's disease usually has an unsatisfactory response to medical and/or surgical therapy. A complete healing of the lesions is rarely obtained by medical treatment, although some partial benefit has been reported following treatment with azathioprine,3 steroids,4 mycophenolate mofetil,5 surgery and hyperbaric oxygen therapy.6 Infliximab, an antitumour necrosis factor (TNF)‐α chimeric monoclonal antibody, has been used successfully in fistulizing perianal Crohn's disease,7 and its potential efficacy in the treatment of cutaneous metastatic complications of Crohn's disease has recently been suggested.2, 8, 9 We report a patient with metastatic Crohn's disease that was treated successfully with infliximab.
Biochemical and clinical implications of proinsulin conversion intermediates.
Authors: B D Given, R M Cohen, S E Shoelson, B H Frank, A H Rubenstein, H S Tager
Journal: Journal of Clinical Investigation (1985)

Since a complete map of insulin-related peptides in humans requires consideration of proinsulin, Arg32/Glu33-split proinsulin, Arg65/Gly66-split proinsulin, des-Arg31,Arg32-proinsulin, des-Lys64, Arg65-proinsulin, and insulin, we applied high performance liquid chromatography coupled with radioimmunoassay to investigate the formation of proinsulin conversion intermediates in vitro and in vivo. Kinetic analysis of proinsulin processing by a mixture of trypsin and carboxypeptidase B (to stimulate in vivo processes) revealed (a) a rapid decline in proinsulin concommitant with formation of conversion intermediates, (b) formation of des-Arg31, Arg32-proinsulin and des-Lys64,Arg65-proinsulin in the ratio 3.3:1 at steady state, and (c) complete conversion of the precursor to insulin during extended incubation. Studies on normal human pancreas identified a similar ratio of des-Arg31,Arg32-proinsulin to des-Lys64,Arg65-proinsulin (approximately 3:1), whereas two insulinomas contained sizable amounts of des-Arg31,Arg32-proinsulin, but barely detectable amounts of des-Lys64,Arg65-proinsulin. None of the tissues contained measurable quantities of Arg32/Glu33- or Arg65/Gly66-split proinsulin. Analysis of plasma from three diabetic subjects managed by the intravenous infusion of human proinsulin revealed less than 1% processing of the circulating precursor to conversion intermediates and no processing of the precursor to human insulin. Nevertheless, analysis of plasma from the same subjects managed by the subcutaneous infusion of proinsulin revealed 4-11% processing of the precursor to intermediates that had the properties of des-Arg31,Arg32-proinsulin and Arg65/Gly66-split proinsulin. We conclude that (a) processing of proinsulin to insulin in vivo as in vitro likely occurs by preferential cleavage at the Arg32-Glu33 peptide bond in proinsulin, (b) proinsulin is inefficiently processed in the vascular compartment, and (c) subcutaneous administration of the precursor can result in the formation of conversion intermediates with the potential for contributing to biological activity.
Mitochondrial gene arrangement of the horseshoe crab Limulus polyphemus L.: conservation of major features among arthropod classes
Authors: J. L. Staton, L. L. Daehler, W. M. Brown
Journal: Molecular Biology and Evolution (1997)

Numerous complete mitochondrial DNA sequences have been determined for species within two arthropod groups, insects and crustaceans, but there are none for a third, the chelicerates. Most mitochondrial gene arrangements reported for crustaceans and insect species are identical or nearly identical to that of Drosophila yakuba. Sequences across 36 of the gene boundaries in the mitochondrial DNA (mtDNA) of a representative chelicerate. Limulus polyphemus L., also reveal an arrangement like that of Drosophila yakuba. Only the position of the tRNA(LEU)(UUR) gene differs; in Limulus it is between the genes for tRNA(LEU)(CUN) and ND1. This positioning is also found in onychophorans, mollusks, and annelids, but not in insects and crustaceans, and indicates that tRNA(LEU)(CUN)-tRNA(LEU)(UUR)-ND1 was the ancestral gene arrangement for these groups, as suggested earlier. There are no differences in the relative arrangements of protein-coding and ribosomal RNA genes between Limulus and Drosophila, and none have been observed within arthropods. The high degree of similarity of mitochondrial gene arrangements within arthropods is striking, since some taxa last shared a common ancestor before the Cambrian, and contrasts with the extensive mtDNA rearrangements occasionally observed within some other metazoan phyla (e.g., mollusks and nematodes).
Morphology after Transluminal Angioplasty in Human Beings
Authors: Peter C. Block, Richard K. Myler, Simon Stertzer, John T. Fallon
Journal: New England Journal of Medicine (1981)

PERCUTANEOUS transluminal angioplasty is frequently used in selected patients to decrease stenoses in atherosclerotic peripheral arteries,1 , 2 renal arteries,3 4 5 6 and coronary arteries.7 8 9 There has been much controversy over the mechanism of successful transluminal angioplasty. It was initially postulated that enlargement of the vascular lumen was due to compression of atheromatous plaque.2 However, experiments in animals and autopsy studies in human beings10 11 12 13 14 15 16 17 have shown that transluminal angioplasty produces endothelial desquamation and splitting of the atheromatous plaque. Attempts to extrapolate these findings to the mechanism of clinically successful angioplasty have been subjected to the criticism that post-mortem tissue and animal models of atherosclerosis . . .
BMA pledges support for armed forces doctors
Authors: L. Beecham
Journal: BMJ (1996)

If the BMA does not get a satisfactory response from the secretary of state for defence about the future of doctors in the armed services it will seek a meeting with the prime minister. That was the pledge that the chairman of the BMA council, Dr Sandy Macara, gave to a conference of armed forces doctors earlier this month.

Dr Macara told the packed audience that the association was worried about armed forces doctors and concerned that many of those …
Abstract 4831: Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain
Authors: Xiaoying Zhuang, Huang-Ge Zhang
Journal: Cancer Research (2012)

Abstract In this study, exosomes used to encapsulate curcumin (Exo-cur) or a Stat3 inhibitor, i.e., JSI124, (Exo-JSI124) were delivered non-invasively to microglila cells via an intranasal route. The results generated from three inflammation mediated disease models, i.e., a LPS induced brain inflammation model, experimental autoimmune encephalitis and a GL26 brain tumor model, showed that mice treated intranasally with Exo-cur or Exo-JSI124 are protected from LPS induced brain inflammation, the progression of MOG peptide induced EAE, and had significantly delayed brain tumor growth in the GL26 tumor model. Intranasal administration of Exo-cur or Exo-JSI124 led to rapid delivery of exosome encapsulated drug to the brain that was selectively taken up by microglial cells, and subsequently induced apoptosis of microglial cells. Our results demonstrate that this strategy may provide a non-invasive and novel therapeutic approach for treating brain inflammatory related diseases. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4831. doi:1538-7445.AM2012-4831
The Need for Concrete Improvement in Abstract Quality
Authors: Margaret A. Winker
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Strain-Encoded CMR for the Detection of Inducible Ischemia During Intermediate Stress
Authors: Grigorios Korosoglou, Stephanie Lehrke, Angela Wochele, Birgit Hoerig, Dirk Lossnitzer, Henning Steen, Evangelos Giannitsis, Nael F. Osman, Hugo A. Katus
Journal: JACC. Cardiovascular imaging (2010)
Full information about trials might be given retrospectively to participants
Authors: S. Clement
Journal: BMJ (1999)

EDITOR—One of the central issues in the debate about informed consent in randomised controlled trials1 has been the ethics of withholding the fact of randomisation from participants—for example, in the trials of support after stroke2 and of management of sore throat.3 Psychologists recognise that it is sometimes necessary to withhold full information from participants, to minimise bias. Our professional code of conduct (http://www.bps.org.uk/charter/codofcon.htm) states that in these situations we must “provide … full information …
Septicemia Due to<i>Klebsiella pneumoniae</i>Originating from a Hand-Cream Dispenser
Authors: Leonard J. Morse, Harvey L. Williams, Francis P. Grenn, Edward E. Eldridge, James R. Rotta
Journal: New England Journal of Medicine (1967)

SECONDARY infection is a major hazard to the hospitalized patient.1 , 2 Numerous institutionacquired infections, attributed to a wide variety of sources and micro-organisms, have been described. The purpose of this report is to identify a unique source recognized during an outbreak of septicemia involving 6 of 13 patients in a medical intensive-care unit. The origin was traced to a dispensing bottle of contaminated lanolin hand cream.Epidemiolocic BackgroundWithin a seventy-two-hour period (February 15 to 17, 1967) 6 patients in the medical intensive care unit had fever, shaking chills, mental confusion or transient hypotension (Table 1). Blood cultures from 5 yielded . . .
COMMENTS ON THE HIGHER X-RAY VOLTAGES
Authors: ALBERT SOILAND
Journal: JAMA (1933)

The headline publicity which has been broadcast over the nation calling attention to this or that 1,000,000 volt x-ray machine as a cancer cure is both ill timed and unfortunate. In the first place, there are in the United States today only two higher voltage institutions (one in California and one in New York) which have successfully maintained a therapeutic voltage over 500,000 for an appreciable time period. In the second place, neither of these institutions, to my knowledge, is willing to claim any extraordinary results or reactions over those formerly achieved. Several years must elapse before an authentic evaluation can be placed on any clinical reactions from this new x-ray colossus which would warrant the assumption that cancer is thereby brought any nearer to solution. From a survey of the results of efforts in developing the higher x-ray voltages up to the present, one may accept as a fact
Abstract A57: Characterization of novel regulators of epithelial-mesenchymal transition in human cancer cells
Authors: Linna Li, Nanping Ai, Mohit Hulsurkar, Wenliang Li
Journal: Cancer Research (2013)

Abstract The epithelial-mesenchymal transition (EMT) confers mesenchymal properties on epithelial cells and has been closely associated with the acquisition of aggressive traits by cancer cells of several cancer types. Recently, a few kinases, such as FYN and c-Met, were reported to participate in regulating EMT. However, the roles of the majority of &amp;gt;700 human kinases in EMT and cancer progression are still unknown. Here we carried out human kinase cDNA screens to identify novel regulators of EMT. Many unknown EMT regulators and a few known ones such as PI3K, PDGFRA, FYN and c-Met, were found to up-regulate mesenchymal marker vimentin. Some also increase expression of fibronectin and N-cadherin, as well as EMT transcriptional regulators, such as ZEB1/2, Snail and Slug. At the same time, the cells acquired mesenchymal phenotypes, such as increased migration/invasion activity, enhanced capability to survive and proliferate in growth factor deprivation condition or under drug treatments. Interestingly, FACS analysis also showed a substantial increase in CD44hiCD24low population in kinase-transducted mammary gland epithelial cells. The increase of CD44hi population could be attributed to increase of a CD44 mesenchymal variant — the standard form CD44s and decrease of the epithelial variant CD44 v8-10. And this alternation was associated with down-regulation of ESRP1 and ESRP2, two splicing factors that regulate CD44 splicing and EMT. Furthermore, the mammary gland epithelial cells undergoing EMT showed increase capability of forming mammosphere and differentiating into other lineage, such as osteoblast and adipocyte. Importantly, some of these novel EMT regulators are associated with tumor progression and stemness of human cancers. Further study of these novel EMT regulators promises to provide new mechanisms of cancer progression, and may also lead to development of new prognostic markers and therapeutics for metastasis. Citation Format: Linna Li, Nanping Ai, Mohit Hulsurkar, Wenliang Li. Characterization of novel regulators of epithelial-mesenchymal transition in human cancer cells. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr A57.