tbuckley/cabot-search huggingface dataset:
Prevention of Corticosteroid-Induced Osteoporosis
Authors: Lenore M. Buckley
Journal: Annals of Internal Medicine (1997)

Letters1 July 1997Prevention of Corticosteroid-Induced OsteoporosisLenore M. Buckley, MD, MPHLenore M. Buckley, MD, MPHMedical College of Virginia; Richmond, VA 23298Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-1-199707010-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Birdsall is correct that the dosage of elemental calcium (not calcium carbonate) used in our study was 1000 mg per day, or four tablets of Os-Cal 250 + D. The milligram dosage of calcium carbonate would be higher. Author, Article, and Disclosure InformationAffiliations: Medical College of Virginia; Richmond, VA 23298 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1997Volume 127, Issue 1Page: 90KeywordsCalciumCarbonatesOsteoporosis Issue Published: 1 July 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Relationship between Thy-1 expression and cell-cycle distribution in human bone marrow hematopoietic progenitors
Authors: Hiroki Takeda, Masuji Yamamoto, Naoko Morita, Takakuni Tanizawa
Journal: American Journal of Hematology (2005)

Abstract Analysis of the relationship between Thy‐1 expression and cell‐cycle distribution of hematopoietic stem cells (HSCs) showed that freshly isolated Thy‐1 + and Thy‐1 − subsets of the CD34 high CD38 − flt‐3 − Lin − population were predominantly in G 0 /G 1 phase and remained essentially quiescent, whereas after 6 days of cytokine stimulation, the Thy‐1 + subset of the population entered the cycling state while the Thy‐1 − subset again remained quiescent. Expression of Thy‐1 antigen resulted in a drastic increase in the percentage of cycling cells in CD34 high CD38 ‐ flt‐3 ‐ Lin ‐ Thy‐1 + ‐ as well as CD34 high CD38 − flt‐3 − Lin − Thy‐1 − ‐cell‐initiated cultures. The Thy‐1 + subset of the CD34 high CD38 − flt‐3 − Lin − population exists in the freshly isolated CD34 high CD38 − flt‐3 − Lin − Thy‐1 + fraction, loses Thy‐1 expression during 6 days, and re‐expresses Thy‐1 for an additional 2 days. Cell‐cycle analysis demonstrated that this unique subset contains abundant S/G 2 M cells. Thus, Thy‐1 expression appears to be an indicator of cell‐cycle phase in targeting HSC, which might serve in the cell subset best suited for gene transfer. Am. J. Hematol. 79:187–193, 2005. © 2005 Wiley‐Liss, Inc.
Effect of nickel chloride on primary antibody production in the spleen.
Authors: J A Graham, D E Gardner, F J Miller, M J Daniels, D L Coffin
Journal: Environmental Health Perspectives (1975)

Mice immunized intraperitoneally with sheep erythrocytes were treated with nickel chloride, a common particulate air pollutant. Primary antibody production in the spleen was examined using a hemolytic plaque technique. A negative linear dose-response relationship (p is less than 0.05) was observed between the logarithm of (plaques/10(6) cells) and the nickel concentration administered. Mice injected with 3.09 mug Ni2+/g body weight displayed lymphocyte function similar to that of control mice. However, injection of 9.26-12.34 mug Ni2+/g caused significant immunosupression (p is less than 0.05).
Interferon α-2a and Dacarbazine in Melanoma
Authors: John M. Kirkwood, M. S. Ernstoff, A. Giuliano, R. Gams, W. A. Robinson, J. Costanzi, P. Pouillart, J. Speyer, M. Grimm, R. Spiegel
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Interferon α-2a and Dacarbazine in Melanoma Get access John M. Kirkwood, John M. Kirkwood Search for other works by this author on: Oxford Academic PubMed Google Scholar M. S. Ernstoff, M. S. Ernstoff Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Giuliano, A. Giuliano Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Gams, R. Gams Search for other works by this author on: Oxford Academic PubMed Google Scholar W. A. Robinson, W. A. Robinson Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Costanzi, J. Costanzi Search for other works by this author on: Oxford Academic PubMed Google Scholar P. Pouillart, P. Pouillart Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Speyer, J. Speyer Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Grimm, M. Grimm Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Spiegel R. Spiegel Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 12, 20 June 1990, Pages 1062–1063, https://doi.org/10.1093/jnci/82.12.1062 Published: 20 June 1990 Article history Received: 09 April 1990 Accepted: 10 April 1990 Published: 20 June 1990
Resuscitating the teaching autopsy
Authors: J. Underwood
Journal: BMJ (2003)

O'Grady rightly laments the exclusion of students from coroner's autopsies in New Zealand. With the worrying decline in the hospital autopsy rate, coroner's cases (about 90% of autopsies in the United Kingdom) are now the main opportunity for medical student teaching.

I am not aware of any similar restriction in the United Kingdom, and there is nothing in the Coroner's Rules 1984 that would automatically prohibit medical students, nurses, or police trainees from attending. Coroner's Rule 7(4) is relevant: “Nothing in the foregoing provisions of this Rule shall be deemed to limit the discretion of the coroner to notify any person of the date, …
Prophylaxis of supraventricular tachycardia.
Authors: A W Segal
Journal: BMJ (1971)

the Jordan Hospital over the course of 11 years, may represent a typical cross-section of more or less sophisticated patients in a Western institutional setting, and their troubles may indeed be unrelated to dapsone.This inference, however, does not invalidate the reports that acute psychosis occurred with some frequency when dapsone was given in high dosage in the early days, and that it is seen in a small but definite pro- portion of patients taking 100 mg or less daily.It would be interesting to ascertain if psychotic episodes, apparently dapsone- related, have been noted in patients taking the drug for such conditions as dermatitis herpetiformis, deep mycetoma, etc.-I am, etc.
Adrenocortical dysfunction in liver disease: A systematic review
Authors: Giuseppe Fede, Luisa Spadaro, Tania Tomaselli, Graziella Privitera, Giacomo Germani, Emmanuel Tsochatzis, Michael Thomas, Pierre-Marc Bouloux, Andrew K. Burroughs, Francesco Purrello
Journal: Hepatology (2012)

In patients with cirrhosis, adrenal insufficiency (AI) is reported during sepsis and septic shock and is associated with increased mortality. Consequently, the term "hepato-adrenal syndrome" was proposed. Some studies have shown that AI is frequent in stable cirrhosis as well as in cirrhosis associated with decompensation other than sepsis, such as bleeding and ascites. Moreover, other studies showed a high prevalence in liver transplant recipients immediately after, or some time after, liver transplantation. The effect of corticosteroid therapy in critically ill patients with liver disease has been evaluated in some studies, but the results remain controversial. The 250-μg adreno-cortico-tropic-hormone stimulation test to diagnose AI in critically ill adult patients is recommended by an international task force. However, in liver disease, there is no consensus on the appropriate tests and normal values to assess adrenal function; thus, standardization of normal ranges and methodology is needed. Serum total cortisol assays overestimate AI in patients with cirrhosis, so that direct free cortisol measurement or its surrogates may be useful measurements to define AI, but further studies are needed to clarify this. In addition, the mechanisms by which liver disease leads to adrenal dysfunction are not sufficiently documented. This review evaluates published data regarding adrenal function in patients with liver disease, with a particular focus on the potential limitations of these studies as well as suggestions for future studies.
Introduction to the <i>IUPHAR Compendium of Voltage-Gated Ion Channels 2005</i>
Authors: William A. Catterall, George Gutman
Journal: Pharmacological Reviews (2005)

The voltage-gated ion channels and their structural relatives comprise a superfamily encoded by at least 143 genes in the human genome and are therefore one of the largest superfamilies of signal transduction proteins, following the G protein-coupled receptors and the protein kinases in number. In
OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer
Authors: Grant C Sellar, Karen P Watt, Genevieve J Rabiasz, Euan A Stronach, Li Li, Eric P Miller, Charles E Massie, Jayne Miller, Bruno Contreras-Moreira, Diane Scott, Iain Brown, Alastair R Williams, Paul A Bates, John F Smyth, Hani Gabra
Journal: Nature Genetics (2003)
Ibuprofen as effective as morphine for fracture pain in children, study shows
Authors: E. Parish
Journal: BMJ (2014)

Ibuprofen should be the drug of choice for analgesia in children with uncomplicated extremity fractures, a study published this week in the journal of the Canadian Medical Association, CMAJ , has shown. It was as effective as oral morphine but produced fewer side effects.

The randomised, blinded trial showed that oral ibuprofen and oral morphine reduced pain scores in children by the same degree. Children tolerated ibuprofen well, with fewer reported adverse effects within 72 hours than for morphine.1

Researchers assessed children (5-17 years old) …
THE INFLUENCE OF PHAGOCYTOSIS ON THE INTRACELLULAR DISTRIBUTION OF GRANULE-ASSOCIATED COMPONENTS OF POLYMORPHONUCLEAR LEUCOCYTES
Authors: Zanvil A. Cohn, James G. Hirsch
Journal: The Journal of Experimental Medicine (1960)

Control and phagocyting populations of rabbit polymorphonuclear leucocytes have been compared in terms of the content and distribution of phagocytin and selected hydrolytic enzymes. Following incubation at 37 degrees C., the cells were disrupted by homogenization and separated into an 8,200 g pellet and supernatant fluid. The high speed pellet from control leucocytes contained all the larger particulate elements of the cell including intact cytoplasmic granules. The ingestion of large numbers of heat-killed bacteria was accompanied by a fourfold reduction in the total phagocytin content of the leucocyte, whereas phagocytosis did not influence the recovery of histone-like bactericidin from nuclei. Engulfment of microorganisms led to a progressive decrease in the activity of phosphatases, beta glucuronidase, and cathepsin extractable from the 8,200 g pellet, with a concomitant increased activity of these enzymes in the supernatant fraction. No significant difference in the total enzyme content of control and phagocyting cells was noted. These findings are consistent with the lysis of granules following phagocytosis and the liberation of granule constituents into the cytoplasm of the leucocyte.
PRAME-Induced Inhibition of Retinoic Acid Receptor Signaling-Mediated Differentiation—A Possible Target for ATRA Response in AML without t(15;17)
Authors: Lars Bullinger, Richard F. Schlenk, Marlies Götz, Ursula Botzenhardt, Susanne Hofmann, Annika C. Russ, Anna Babiak, Lu Zhang, Vanessa Schneider, Konstanze Döhner, Michael Schmitt, Hartmut Döhner, Jochen Greiner
Journal: Clinical Cancer Research (2013)

In acute myeloid leukemia (AML) without retinoic acid receptor (RAR) rearrangement, the effect of all-trans-retinoic acid (ATRA) is still poorly understood despite an association of NPM1 mutation and ATRA response. Recently, preferentially expressed antigen in melanoma (PRAME) has been shown to be a dominant repressor of RAR signaling.Thus, we further investigated ATRA response mechanisms, especially the impact of PRAME expression on ATRA responsiveness. We profiled gene expression in diagnostic samples derived from our AML HD98B trial, in which ATRA was administered in addition to intensive chemotherapy.Our data revealed a PRAME expression-associated gene pattern to be significantly enriched for genes involved in the retinoic acid metabolic process. In leukemia cell line models, we could show that retinoic acid-regulated cell proliferation and differentiation are impacted by PRAME expression. In patients with primary AML, repressor activity of high-PRAME levels might be overcome by the addition of ATRA as indicated by better outcome in 2 independent studies (P = 0.029).PRAME seems to impair differentiation and to increase proliferation likely via blocking RAR signaling, which might be reversed by ATRA. PRAME therefore represents a promising target for both ATRA treatment and possibly future immunotherapeutic approaches in AML.
Disregard of Patients' Preferences Is a Medical Error
Authors: Theresa A. Allison, Rebecca L. Sudore
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
IL-12 enhances the natural killer cell cytokine response to Ab-coated tumor cells
Authors: Robin Parihar, Julie Dierksheide, Yan Hu, William E. Carson
Journal: Journal of Clinical Investigation (2002)

The anti-tumor activity of recombinant mAb's directed against tumor cell growth receptors has generally been considered to result from direct antiproliferative effects, the induction of apoptosis, or possibly Ab-dependent cellular cytotoxicity mediated against tumor targets. However, it remains unclear to what degree these mechanisms actually aid in the clearance of Ab-coated tumor cells in vivo. We show here that NK cells secrete a distinct profile of potent immunostimulatory cytokines in response to dual stimulation with Ab-coated tumor cells and IL-12. This response could not be duplicated by costimulation with other ILs and was significantly enhanced in the presence of monocytes. Cytokine production was dependent upon synergistic signals mediated by the activating receptor for the Fc portion of IgG (FcgammaRIII) and the IL-12 receptor expressed on NK cells. Coadministration of Ab-coated tumor cells and IL-12 to BALB/c mice resulted in enhanced circulating levels of NK cell-derived cytokines with the capacity to augment anti-tumor immunity. These findings suggest that, in addition to mediating cellular cytotoxicity and apoptosis, the anti-tumor activity of mAb's might also result from activation of a potent cytokine secretion program within immune effectors capable of recognizing mAb-coated targets.
The Story of Cancer: On Its Nature, Causes, and Control
Authors: Stewart F. Cramer
Journal: JAMA (1978)

The history of cancer research resembles the story of the blind men and the elephant. Variation in methods of study has generated widely disparate concepts of the fundamental nature of neoplastic disease. In<i>The Story of Cancer</i>, Dr Armin C. Braun shares the perspective he developed from studying plant tumors. Although he derives his ideas from botanical experiments, he effectively supports his point of view with evidence from experimental animal and tissue culture work and from reported observations of human tumors. Many of the 284 references postdate his previous books on this subject. In the introductory chapters, the author lays a solid foundation with a concise historical review of early thoughts about cancer and fundamental discoveries in genetics. He presents this complex material in a straightforward, well-organized manner, emphasizing the means by which scientists have progressively unraveled the mechanisms of basic life processes. In the core of the book, he
Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo
Authors: Yoshinobu Manome, Patrick Y. Wen, Yonghe Dong, Toshihide Tanaka, Beverly S. Mitchell, Donald W. Kufe, Howard A. Fine
Journal: Nature Medicine (1996)
Noninvasive evaluation of sympathetic nervous system in human heart by positron emission tomography.
Authors: M Schwaiger, V Kalff, K Rosenspire, M S Haka, E Molina, G D Hutchins, M Deeb, E Wolfe, D M Wieland
Journal: Circulation (1990)

The noninvasive functional characterization of the cardiac sympathetic nervous system by imaging techniques may provide important pathophysiological information in various cardiac disease states. Hydroxyephedrine labeled with carbon 11 has been developed as a new catecholamine analogue to be used in the in vivo evaluation of presynaptic adrenergic nerve terminals by positron emission tomography (PET). To determine the feasibility of this imaging approach in the human heart, six normal volunteers and five patients with recent cardiac transplants underwent dynamic PET imaging after intravenous injection of 20 mCi [11C]hydroxyephedrine. Blood and myocardial tracer kinetics were assessed using a regions-of-interest approach. In normal volunteers, blood 11C activity cleared rapidly, whereas myocardium retained 11C activity with a long tissue half-life. Relative tracer retention in the myocardium averaged 79 +/- 31% of peak activity at 60 minutes after tracer injection. The heart-to-blood 11C activity ratio exceeded 6:1 as soon as 30 minutes after tracer injection, yielding excellent image quality. Little regional variation of tracer retention was observed, indicating homogeneous sympathetic innervation throughout the left ventricle. In the transplant recipients, myocardial [11C]hydroxyephedrine retention at 60 minutes was significantly less (-82%) than that of normal volunteers, indicating only little non-neuronal binding of the tracer in the denervated human heart. Thus, [11C]hydroxyephedrine, in combination with dynamic PET imaging, allows the noninvasive delineation of myocardial adrenergic nerve terminals. Tracer kinetic modeling may permit quantitative assessment of myocardial catecholamine uptake, which will in turn provide insights into the effects of various disease processes on the neuronal integrity of the heart.
Turning the tables on probe pressures--go with the flow, abandon the scan?
Authors: M. M. Fluke
Journal: JAMA (1992)

To the Editor.  —I wish to call to your attention an error in the article entitled Diagnosis of Ischemic Stroke by Dr Caplan published in JAMA . 1   The caption to Fig 2 (p 2417) states Transcranial Doppler ultrasound images. Pressure, amplitude, and pulsation are damped in the left intracranial vertebral artery compared with the right vertebral artery. Basilar artery pressures are normal [emphasis added]. The transcranial Doppler ultrasound images displayed are graphs of blood flow velocities vs time (as described in the text on p 2416). Pressure data are not displayed.  An arterial stenosis severe enough to reduce blood flow velocities would also be expected to reduce arterial blood pressures distal to the lesion. However, one should be aware that, with arterial Doppler studies, one is imaging flow velocity directly, and the status of the pressure can only be inferred.
Review: In postmenopausal women and older men, vitamin D plus calcium reduces some fractures
Authors: KoKo Aung
Journal: Annals of Internal Medicine (2014)

ACP Journal Club16 September 2014Review: In postmenopausal women and older men, vitamin D plus calcium reduces some fracturesKoKo Aung, MD, MPHKoKo Aung, MD, MPHUniversity of Texas Health Science Center, San Antonio, Texas, USA (K.A.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-161-6-201409160-02005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationAvenell A, Mak JC, O'Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev. 2014;4:CD000227. https://pubmed.ncbi.nlm.nih.gov/24729336Clinical Impact RatingsGIM/FP/GP: Geriatrics: Reference1 Chung M, Lee J, Terasawa T, Lau J, Trikalinos TA. Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med. 2011;155:827-38. [PMID: 22184690] Google Scholar2 Moyer VA; U.S. Preventive Services Task Force. Vitamin D and calcium supplementation to prevent fractures in adults: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2013;158:691-6. [PMID: 23440163] Google Scholar3 Mouyis M,Ostor A,Crisp A, et al. Hypovitaminosis D among rheumatology outpatients in clinical practice. Rheumatology 2008;47:1348-51. [PMID: 18499714] Google Scholar Author, Article, and Disclosure InformationAuthors: KoKo Aung, MD, MPHAffiliations: University of Texas Health Science Center, San Antonio, Texas, USA (K.A.)This article was published at Annals.org on 2 September 2014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrinciples of Diagnosis and Treatment of OsteoporosisDoes the Metabolically Healthy Obese Phenotype Protect Adults with Class III Obesity from Biochemical Alterations Related to Bone Metabolism? 16 September 2014Volume 161, Issue 6Page: JC5KeywordsBoneCalciumElderlyHip fracturesOsteoporosisRenal failureRisk ratioSystematic reviewsVitamin DVitamin D deficiency ePublished: 16 September 2014 Issue Published: 16 September 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Intrathecal Gadolinium for Magnetic Resonance Myelography in Spontaneous Intracranial Hypotension: Valuable But May Be Risky—Reply
Authors: Athina Papadopoulou, Frank J. Ahlhelm, Till Sprenger
Journal: JAMA Neurology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal