tbuckley/cabot-search huggingface dataset:
Dermoscopic features and follow‐up changes of acral melanocytic naevi in childhood and adolescence
Authors: M.C. Fargnoli, M. Suppa, T. Micantonio, A. Antonini, S. Tambone, K. Peris
Journal: British Journal of Dermatology (2013)

Journal Article Dermoscopic features and follow‐up changes of acral melanocytic naevi in childhood and adolescence Get access M.C. Fargnoli, M.C. Fargnoli Department of Dermatology University of L'Aquila via Vetoio‐Coppito 2 67100 L'Aquila Italy Search for other works by this author on: Oxford Academic Google Scholar M. Suppa, M. Suppa Department of Dermatology University of L'Aquila via Vetoio‐Coppito 2 67100 L'Aquila Italy Search for other works by this author on: Oxford Academic Google Scholar T. Micantonio, T. Micantonio Department of Dermatology University of L'Aquila via Vetoio‐Coppito 2 67100 L'Aquila Italy Search for other works by this author on: Oxford Academic Google Scholar A. Antonini, A. Antonini Department of Dermatology University of L'Aquila via Vetoio‐Coppito 2 67100 L'Aquila Italy Search for other works by this author on: Oxford Academic Google Scholar S. Tambone, S. Tambone Department of Dermatology University of L'Aquila via Vetoio‐Coppito 2 67100 L'Aquila Italy Search for other works by this author on: Oxford Academic Google Scholar K. Peris K. Peris Department of Dermatology University of L'Aquila via Vetoio‐Coppito 2 67100 L'Aquila Italy Correspondence Ketty Peris. E‐mail: ketty.peris@univaq.it Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 170, Issue 2, 1 February 2014, Pages 374–381, https://doi.org/10.1111/bjd.12667 Published: 01 February 2014
Extensive Hypertensive Work-up: Pro
Authors: James C. Melby
Journal: JAMA (1975)

IT IS estimated that approximately 20% of the adult population in the United States has arterial hypertension, with blood pressures at or above 160/95 mm Hg on repeated examination.1It is also conceded that arterial hypertension is the most important risk factor for congestive cardiac failure, stroke, and renal failure, and it is among the most important risk factors for coronary artery disease.2-4Furthermore, it has been established that the treatment of arterial hypertension will effectively prevent complications of stroke, congestive heart failure, and renal failure. As a public health issue, it is conceded that it would be desirable to detect and to treat all hypertensive patients.  Because of the epidemic proportions of the hypertension problem, thoughtful clinicians would like to reduce to an essential minimum the diagnostic evaluation, cost of workup, and inconvenience. I assume, logically, that it is to the patient's benefit to begin one of
Metastases to Bone from Malignant Thymoma Detected by Technetium Phosphate and Gallium-67 Scintigraphy
Authors: ELIZABETH T. CANCROFT, DANUTA MONTORFANO, C RICHARD GOLDFARB
Journal: Clinical Nuclear Medicine (1978)

CANCROFT, ELIZABETH T. M.D.; MONTORFANO, DANUTA M.D.; GOLDFARB, C RICHARD M.D. Author Information
Diagnosis and treatment of venous thromboembolism by consultants in Scotland.
Authors: A G Prentice, G D Lowe, C D Forbes
Journal: BMJ (1982)

A questionnaire was sent to 508 consultants in Scotland likely to encounter deep vein thrombosis and pulmonary embolism to assess their current standard practice in diagnosis and treatment of these disorders. Replies were received from 358 (70.5%). In deep vein thrombosis 47% and in pulmonary embolism 33% of consultants usually depended on clinical observation alone for diagnosis. In deep vein thrombosis 37% used venography to supplement clinical diagnosis and in pulmonary embolism 13% used angiography and 53% used isotopic scanning. Almost all consultants treated deep vein thrombosis (95%) and pulmonary embolism (99%) with anticoagulants. Most consultants (81%) gave heparin by intravenous infusion. Although many consultants gave intravenous heparin for more than three days (49.5% in deep vein thrombosis and 61% in pulmonary embolism), 25% of these consultants did not use any laboratory monitoring of heparin's effect. Large numbers of consultants gave warfarin for more than three months (20% in deep vein thrombosis and 47% in pulmonary embolism). There was a significant tendency to give heparin (p less than 0.01) and warfarin (p less than 0.001) for longer periods in pulmonary embolism than in deep vein thrombosis. This survey shows a widely varying practice and underlines the need for further controlled studies to provide clear guidance in the management of deep vein thrombosis and pulmonary embolism.
Perceptual Characteristics Distinguishing Auditory Hallucinations in Schizophrenia and Acute Alcoholic Psychoses
Authors: MURRAY ALPERT, KENNETH N. SILVERS
Journal: American Journal of Psychiatry (1970)

By means of a questionnaire the authors compared the characteristics of auditory hallucinations experienced by 45 schizophrenics and those experienced by 18 patients with alcoholic hallucinosis. The alcoholics' hallucinations were localized in space and had a greater frequency than those of the schizophrenics; the frequency was relatively independent of emotional state. The schizophrenics' hallucinations had a cognitive taint, were poorly localized, and showed a sensitivity to emotional arousal.
Gastrointestinal symptoms in patients infected with human immunodeficiency virus: relevance of infective agents isolated from gastrointestinal tract.
Authors: R Ullrich, W Heise, C Bergs, M L'age, E O Riecken, M Zeitz
Journal: Gut (1992)

The correlation of gastrointestinal symptoms and infections in 186 consecutive patients with human immunodeficiency virus (HIV) infection undergoing diagnostic endoscopy (oesophagogastroduodenoscopy, n = 124; colonoscopy, n = 37; both, n = 25) was investigated. Biopsy and stool samples were examined for infective agents. Only weight loss (p = 0.003) and dysphagia (p = 0.027) were more common in patients at stage CDC IV compared with earlier stages. In three of 27 patients at stage II/III and in 93 of 159 patients at stage IV an infective agent was identified in stool or gastrointestinal biopsy specimen (p &lt; 0.001). Cytomegalovirus (n = 35), Candida sp (n = 28), M avium complex (n = 10), and Cryptosporidium (eight) were the most frequent agents detected. At stage IV, diarrhoea was more frequent in infected compared with non-infected patients (p = 0.006); however, an infective agent was also found in 39 of 82 patients at stage IV without diarrhoea. The frequency of gastrointestinal symptoms was not consistently increased in patients harbouring specific infective agents compared with non-infected patients. Our findings indicate that the pathogenic relevance of a gastrointestinal infection in HIV infected patients has to be verified and indirectly support the existence of an HIV associated enteropathy.
Agenesis of the Gallbladder
Authors: DAVID M. WARSHAUER, JANA L. SULZER
Journal: Clinical Nuclear Medicine (1988)

Congenital absence of the gallbladder occurs with an estimated incidence based on autopsy studies of approximately 0.03-0.06%. Although slightly more than half of these cases are found in infants or children with other congenital anomalies, the rest are often undiscovered or are noted as incidental findings in adults (1-3). When such patients present with right upper quadrant pain, evaluation by hepatobiliary imaging produces an inevitable false-positive result.
The Mechanism of Thyrocalcitonin Action: Inhibition of Bone Resorption.
Authors: Maurice M. Pechet
Journal: Annals of Internal Medicine (1966)

s1 May 1966The Mechanism of Thyrocalcitonin Action: Inhibition of Bone Resorption.Maurice M. Pechet, M.D., Ph.D., Heinz F. Kohler, Ph.D.Maurice M. Pechet, M.D., Ph.D.Search for more papers by this author, Heinz F. Kohler, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1159_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe results of our studies of thyrocalcitonin action indicate that thyrocalcitonin inhibits bone resorption. Thyrocalcitonin was isolated from thyroids of freshly slaughtered hogs and purified extensively so that in the intact rat, 50 µg of purified thyrocalcitonin caused a decrease within 1 hour in serum calcium of 2.2 mg/100 ml and in serum phosphates of 1.1 mg/100 ml. The mechanism of this action on serum calcium and phosphates was investigated in special, single, unanesthetized rat preparations. Constant infusions of dextrose, sodium chloride and potassium chloride were maintained through indwelling gastric and venous catheters. Urine was collected at 30-minute intervals over... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Maurice M. Pechet, M.D., Ph.D.; Heinz F. Kohler, Ph.D.Affiliations: Cambridge, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1159-1160KeywordsBone resorptionCalciumCathetersGlucosePhosphatesPotassium chlorideSodium chlorideThyroidUrine ePublished: 1 December 2008 Issue Published: 1 May 1966 PDF downloadLoading ...
Antral motility in patients with cirrhosis with or without gastric antral vascular ectasia.
Authors: J Charneau, R Petit, P Cales, A Dauver, J Boyer
Journal: Gut (1995)

Gastric motility has not been extensively studied in patients with cirrhosis and gastric antral vascular ectasia (GAVE) may be associated with antropyloric dysfunction. This study therefore looked at antral motility using ultrasound in patients with alcoholic cirrhosis with or without GAVE. Twenty six patients were included: 10 patients with cirrhosis without GAVE, eight patients with cirrhosis and GAVE, and eight controls without liver disease. Measurement of antral area and antral contractions (amplitude and frequency) was performed for three hours after ingestion of a standardised solid-liquid meal. Antral area half time (mean (SD)) was not significantly increased in patients with cirrhosis without GAVE (84 (42) min), but increased by 120% (123 (43) min; p &lt; 0.01) in patients with GAVE compared with controls (56 (26) min). GAVE patients exhibited the same frequency and amplitude of antral contractions at each time point as controls and had the same tendency to increase these values over time although this was attenuated in the late postprandial phase. In contrast, cirrhotic patients without GAVE exhibited a significantly higher frequency and amplitude of antral contractions during the initial postprandial phase but showed no change in either frequency or amplitude over time. In conclusion, in cirrhosis there is an abnormal antral motor response to a meal, which has a different pattern over time in patients with or without GAVE.
Long‐term evaluation of usefulness of skin and incremental challenge tests in patients with history of adverse reaction to local anesthetics
Authors: J.‐B. Wasserfallen, P. C. Frei
Journal: Allergy (1995)

A variety of adverse reactions to local anesthetics has been described, some of which are thought to be allergic. Different protocols of prick and intradermal skin tests as well as subcutaneous challenge tests are used to select a local anesthetic which can safely be used. Their long‐term effectiveness has not yet been assessed. Twenty‐eight patients with a history of adverse reaction to local anesthetics were evaluated over a 3‐year period. Loss of consciousness occurred in eight patients, skin reaction in nine, and vagal symptoms in eight. Various reactions were recorded in the remaining three patients. Rapid spontaneous recovery was the rule, suggesting that immediate allergic reaction and, in particular, anaphylactic reaction were unlikely. Investigation allowed the selection of a tolerated anesthetic in all cases. Reexposure occurred in 19 patients 16–50 months after evaluation and 6.8 ± 5.5 years after the first reaction. No patient presented a second reaction. In conclusion, adverse reactions to local anesthetics seem to be, in most cases, not allergic in nature. Evaluation protocols are effective in selecting an agent susceptible to tolerance, but are time consuming. However, they probably contribute to an important reassurance effect that is likely to increase tolerance to subsequent local anesthetic administration. Simplification of the protocols and better patient selection are proposed.
L.I.ON. Study: efficacy and tolerability of continuous terbinafine (LamisilR) compared to intermittent itraconazole in the treatment of toenail onychomycosis
Authors: None Sigurgeirsson, None Billstein, None Rantanen, None Ruzicka, None Di Fonzo, None Vermeer, None Goodfield, None Evans
Journal: British Journal of Dermatology (1999)

We undertook a prospective, randomised, double-blind, double-dummy, multicentre, parallel-group study to compare the efficacy and tolerability of continuous terbinafine (Lamisil®) with intermittent itraconazole (Sporanox®) in the treatment of toenail onychomycosis. A total of 496 patients (age range 18–75 years) with a clinical diagnosis of dermatophyte toenail onychomycosis, confirmed by positive mycological culture and microscopy (KOH), were recruited from 35 centres in six European countries. They were randomly divided into four parallel groups to receive either terbinafine 250 mg/day for 12 or 16 weeks (groups T12 and T16), or itraconazole 400 mg/day for 1 week in every 4 weeks for 12 or 16 weeks (groups I3 and I4). The primary efficacy measurement at week 72 was mycological cure, defined as negative microscopy and negative culture of samples from the target toenail. At week 72, the mycological cure rates were 75.5% (81/107) in the T12 group and 80.8% (80/99) in the T16 group, compared with 38.3% (41/107) in the I3 group and 49.1% (53/108) in the I4 group. All comparisons (T12 vs. I3, T12 vs. I4, T16 vs. I3, T16 vs. I4) showed significantly higher cure rates in the terbinafine groups (all P < 0.0001). In addition, all secondary clinical outcome measures were significantly in favour of terbinafine at week 72. Both treatments were well tolerated, with no significant differences in the number or type of adverse events reported. We conclude that continuous terbinafine is significantly more effective than intermittent itraconazole in the treatment of toenail dermatophyte onychomycosis.
Natural killer cell degranulation capacity predicts early onset of the immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients with tuberculosis
Authors: Polidy Pean, Eric Nerrienet, Yoann Madec, Laurence Borand, Didier Laureillard, Marcelo Fernandez, Olivier Marcy, Chan Sarin, Kerya Phon, Sylvia Taylor, Gianfranco Pancino, Françoise Barré-Sinoussi, Daniel Scott-Algara
Journal: Blood (2012)
ACE inhibition enhances cardiac vagal tone both during night- and daytime in patients with congestive heart failure
Authors: Jan Brouwer, Stan A.J. van dan Broek, Dirk J. van Veldhulsen, Arie J.Man in't Veld, Jaap Haaksma, W.Arnold Dijk, K.I. Lie
Journal: Journal of the American College of Cardiology (1996)
Respiration During Snow Burial Using an Artificial Air Pocket
Authors: Colin K. Grissom
Journal: JAMA (2000)

Asphyxia is the most common cause of death after avalanche burial. A device that allows a person to breathe air contained in snow by diverting expired carbon dioxide (CO2) away from a 500-cm3 artificial inspiratory air pocket may improve chances of survival in avalanche burial.To determine the duration of adequate oxygenation and ventilation during burial in dense snow while breathing with vs without the artificial air pocket device.Field study of physiologic respiratory measures during snow burial with and without the device from December 1998 to March 1999. Study burials were terminated at the subject's request, when oxygen saturation as measured by pulse oximetry (SpO2) dropped to less than 84%, or after 60 minutes elapsed.Mountainous outdoor site at 2385 m elevation, with an average barometric pressure of 573 mm Hg.Six male and 2 female volunteers (mean age, 34.6 years; range, 28-39 years).Burial time, SpO2, partial pressure of end-tidal CO2 (ETCO2), partial pressure of inspiratory CO2 (PICO2), respiratory rate, and heart rate at baseline (in open atmosphere) and during snow burial while breathing with the device and without the device but with a 500-cm3 air pocket in the snow.Mean burial time was 58 minutes (range, 45-60 minutes) with the device and 10 minutes (range, 5-14 minutes) without it (P=.001). A mean baseline SpO2 of 96% (range, 90%-99%) decreased to 90% (range, 77%-96%) in those buried with the device (P=.01) and to 84% (range, 79%-92%) in the control burials (P=.02). Only 1 subject buried with the device, but 6 control subjects buried without the device, decreased SpO2 to less than 88% (P=.005). A mean baseline ETCO2 of 32 mm Hg (range, 27-38 mm Hg) increased to 45 mm Hg (range, 32-53 mm Hg) in the burials with the device (P=.02) and to 54 mm Hg (range, 44-63 mm Hg) in the control burials (P=.02). A mean baseline PICO2 of 2 mm Hg (range, 0-3 mm Hg) increased to 32 mm Hg (range, 20-44 mm Hg) in the burials with the device (P=.01) and to 44 mm Hg (range, 37-50 mm Hg) in the control burials (P=.02). Respiratory and heart rates did not change in burials with the device but significantly increased in control burials.In our study, although hypercapnia developed, breathing with the device during snow burial considerably extended duration of adequate oxygenation compared with breathing with an air pocket in the snow. Further study will be needed to determine whether the device improves survival during avalanche burial.
ALCOHOL: ITS USE AND ABUSE: LADY PRIESTLEY MEMORIAL LECTURE
Authors: W. E. Dixon
Journal: BMJ (1924)

T Jom 34r - Everywhere your ambassador was met with the greatest courtesy and friendliness.It is not easy to convey in words how much I appreciate the whole-hearted welcome given me in our big southern continent.The kindness and urbanity meted out to me, and to my son who accompanied me, were generously and spontaneously given wherever we went-in the Government Houses, the Residencies, where we were received as honoured guests (Sir Alexander MacCormick acted right royally for the late Governor-General of New South Wales), and in the homes of our medical colleagues, where we were privileged to join the family group-
Problems in congenital dislocation of the hip.
Authors: A J Harrold
Journal: BMJ (1977)

When congenital dislocation of the hip (CDH) is first recognised late in children over 1 year old the results of treatment are far from perfect. Even of those treated with apparent success half can be expected to have a painful hip by the age of 30.1 The introduction of routine screening of the newborn by von Rosen,2 Barlow,3 and Coleman4 raised the hope that treatment begun at birth would produce much better or even perfect results. This hope has indeed been fulfilled in that many children now born with a dislocated hip respond to a short period of splinting in infancy by developing a joint which in later childhood is clinically and radiologically indistinguishable from normal. Yet there remain difficulties, doubts, and disappoint ments, some of which I will examine briefly.
Ga-67 Citrate and F-18 FDG Uptake in Spironolactone-Induced Gynecomastia
Authors: Kazuki Fukuchi, Hideyuki Sasaki, Takahiro Yokoya, Teruo Noguchi, Yoichi Goto, Kohei Hayashida, Yoshio Ishida
Journal: Clinical Nuclear Medicine (2005)

We evaluated a male patient with chronic heart failure using Ga-67 citrate and F-18 FDG imaging to eliminate secondary dilated cardiomyopathy resulting from sarcoidosis. Tracer accumulated bilaterally in the breast tissue during both imaging procedures. This uptake was probably the result of bilateral gynecomastia caused by therapeutic spironolactone administration in addition to standard therapy for chronic heart failure.
Targeting Tumor-Infiltrating B Cells in Cutaneous T-Cell Lymphoma
Authors: Sebastian Theurich, Max Schlaak, Harold Steguweit, Lukas C. Heukamp, Kerstin Wennhold, Peter Kurschat, Anja Rabenhorst, Karin Hartmann, Hans Schlösser, Alexander Shimabukuro-Vornhagen, Udo Holtick, Michael Hallek, Rudolf Stadler, Michael von Bergwelt-Baildon
Journal: Journal of Clinical Oncology (2014)
A CASE OF TULAREMIA IN NEW YORK STATE
Authors: Jerome A. Murphy
Journal: JAMA (1928)

R. B., aged 35, employed as the steward of a club, where he was required to dress meats and to prepare meals, was taken ill, Dec. 4, 1927, with chills, headache and general malaise. December 6, when I was called to attend him, he was suffering from abdominal pains, spasmodic in character, pains in the back and muscles of the arms, vomiting, diarrhea, bloody stools and prostration. The abdomen was generally tender and distended. There was no sign of rigidity. The temperature was 101.5 F., the pulse 90 and respirations 20. Further examination revealed a small area of inflammation over the distal phalangeal joint of the middle finger of the right hand. This he attributed to a scratch received while dressing rabbits, November 30, when his finger rubbed against a sharp rib bone. This area was dressed and bandaged.  The abdominal symptoms subsided after three days and the temperature dropped to
A Cautionary Note on Market Reforms in Health Care
Authors: Eli Ginzberg
Journal: JAMA (1995)

IN DECIDING not to act on the Clinton health reform proposals in September 1994, Congress voted against an enlarged role for the federal government in health care. But that action did not suggest, much less confirm, its satisfaction with the status quo or its indifference to rapidly rising health care expenditures, growing numbers of the uninsured, and the presence of considerable waste and fraud. In the ensuing months the American public has been informed by a growing number of interested parties that "the market" will achieve many, if not all, of the reforms that President Clinton had earlier identified as health system priorities. Economists have always favored reliance on the market to achieve productivity gains, a predilection that is shared by the new Republican majority and by the corporate executives of managed care companies, old and new, that ascribe their growing profitability to the virtues of the market. In short,
Physical Inactivity among Young People
Authors: Richard P Troiano
Journal: New England Journal of Medicine (2002)

It is widely recognized that the increasing proportion of overweight children and adolescents in the United States is a serious public health issue. Fifteen percent of young Americans are overweight — up from approximately 5 percent in the early 1970s. This dramatic increase is associated with the emergence of type 2 diabetes mellitus as a growing health problem among children. Black and Hispanic children have both a higher prevalence of overweight and a greater risk of type 2 diabetes than do white children. The rising prevalence of overweight and obesity indicates that, increasingly, young people have an energy intake that . . .
A first-in-human study of intravenous BAL101553, a novel microtubule inhibitor, in patients with advanced solid tumors
Authors: L. Rhoda Molife, J. King, A. Smith, M. D'arcangelo, N. Brown, N. Diamantis, H. Lane, A.H. Schmitt Hoffmann, M. Engelhardt, R. Plummer, R. Kristeleit
Journal: Annals of Oncology (2015)