Zomepirac and Renal Failure
Authors: SCOTT J. RATNER
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 June 1982Zomepirac and Renal FailureSCOTT J. RATNER, M.D.SCOTT J. RATNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-6-793_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Zomepirac sodium, a recently introduced non-steroidal anti-inflammatory drug, has been heavily promoted for use as an analgesic (1). I report a case of acute renal failure that was likely due to the use of zomepirac sodium.A previously healthy 26-year-old male physician who was taking no prescribed or over-the-counter medications took one 50-mg tablet of zomepirac sodium for relief of a simple headache. He awoke the next morning (approximately 12 hours after ingestion) feeling nauseated and weak but went to work. During the day nausea persisted, diffuse abdominal and flank pains developed, and weakness progressed, forcing him...References1. LEWIS J. Zomepirac sodium. A new non-addicting analgesic. JAMA. 1981;246:377-9. CrossrefMedlineGoogle Scholar2. BOUDREAUMANDIN RH. The role of prostaglandins in the regulation of renal function during chronic pericardial tamponade. Effect of indomethacin and arachadonic acid on renal function in cardiac edema. Circ Res. 1978;26:867A. Google Scholar3. BOYERZIAREYNOLDS TPT. The effect of indomethacin and prostaglandin A1 on renal function and plasma renin activity in alcoholic liver disease. Gastroenterology. 1979;77:215-22. CrossrefMedlineGoogle Scholar4. BREZINKATZSCHWARTZCHINITZ JSAJ. Reversible renal failure and nephrotic syndrome associated with nonsteroidal anti-inflammatory drugs. New Engl J Med. 1979;301:1271-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Presbyterian Hospital New York, NY 10032 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByImmunologically Mediated Nephritis Induced by Toxins and DrugsSuprofen and Acute Renal FailureNINA S. DAVIS, M.D., AARON SPITAL, M.D., DONALD E. KAMM, M.D.Suprofen-Induced Acute Renal FailureReversible Renal Failure and Nephrotic Syndrome Without Interstitial Nephritis From ZomepiracStatement on the Release of Ibuprofen as an Over-the-Counter MedicineFocal renal cortical necrosis associated with zomepiracA Zomepirac Reaction Mimicking Ectopic PregnancyNephrotoxicity of Nonsteroidal Anti-Inflammatory DrugsAntiinflammatory analgesics and durgs used in rheumatoid arthritis and goutReversible Renal Failure Associated with Ibuprofen: Case Report and Review of the LiteratureAccidents néphrologiques des anti-inflammatoires non stéroïdiensZomepirac Sodium for Primary Dysmenorrhea SyndromeNephrotoxicity of Nonsteroidal Anti-Inflammatory Agents 1 June 1982Volume 96, Issue 6_Part_1Page: 793-793KeywordsAbdominal painAcute renal failureAnalgesicsDrugsEmotionsHeadachesIngestionNauseaRenal failureSodium Issue Published: 1 June 1982 PDF DownloadLoading ...