tbuckley/cabot-search huggingface dataset:
Leaving the Pediatrician for the Internist
Authors: GUILIO J. BARBERO
Journal: Annals of Internal Medicine (1982)

Editorials1 May 1982Leaving the Pediatrician for the InternistGUILIO J. BARBERO, M.D.GUILIO J. BARBERO, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-5-673 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the past 2 or 3 decades an increasing number of young patients with chronic disease have been more effectively cared for during childhood and thus are moving into adulthood with all expectations of life as an adult. The transition is not easy for the young patient who has been handicapped for many years. The patient faces the change from being treated by a pediatrician of long contact and of known disposition to being treated by an internist who is a stranger. This shift brings strain for both the patient and for the two physicians: All three must face the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Child Health University of Missouri Columbia, Missouri PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTransitional Care in Rheumatology: a Review of the Literature from the Past 5 YearsSlow Steps Toward TransitionHelping Health Services to Meet the Needs of Young People with Chronic Conditions: Towards a Developmental Model for TransitionTransition of Care in Adolescents With Cerebral Palsy: A Survey of Current PracticesDesigning patient-centric applications for chronic disease managementTransition from Child-Oriented to Adult-Oriented Health CareBridging the gapsTransition of the Patient With Inflammatory Bowel Disease From Pediatric to Adult Care: Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and NutritionBarriers and Good Practice in Transition from Paediatric to Adult CareYoung Adults With Diabetes: Need for a new treatment paradigmEffective transition from paediatric to adult servicesModalités du passage des adolescents diabétiques de la pédiatrie aux structures pour adultes dans la région Paris-Île-de-France: un appel au travail collaboratif pour améliorer la qualité des soinsTransition to adult health care for adolescents and young adults with cancerLife Beyond Pediatrics: Transition of Chronically III Adolescents from Pediatric to Adult Health Care SystemsFamily Physician RediscoveredDAVID E. REED, M.D. 1 May 1982Volume 96, Issue 5Page: 673-674KeywordsMotivationYoung adults Issue Published: 1 May 1982 PDF DownloadLoading ...
OSTEOPROTOGERIN AND OSTEOPONTIN SERUM LEVELS ARE ASSOCIATED WITH MULTIVESSEL CORONARY ARTERY DISEASE
Authors: Konstantinos Maniatis, Gerasimos Siasos, Dimitris Tousoulis, Evangelos Oikonomou, Marina Zaromitidou, Stamatios Kioufis, Theodore Paraskevopoulos, Konstantinos Zisimos, Stavroula Michalea, Antigoni Miliou, Marilena Kollia, Athanasios G. Papavassiliou, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2012)
Atypical exanthem: polymerase chain reaction spots the cause
Authors: A.J. Harris, P. Muir, A.T. Williams, E.M.E. MacMahon
Journal: British Journal of Dermatology (2003)

A haemodialysis patient developed a widespread haemorrhagic macular rash (Fig. 1) 10 days after varicella onset in a nursing contact. The rash was not typical of varicella; herpesviruses were not detected by culture or electron microscopy and the patient had in any case tested varicella‐zoster virus (VZV) seropositive. Biopsy, however, showed intranuclear inclusions suggestive of herpesvirus infection (Fig. 2), VZV DNA was detected by polymerase chain reaction (PCR), and an anamnestic rise of high‐avidity VZV‐specific IgG followed the rash (Fig. 3), indicating secondary varicella. This case demonstrates the utility of PCR in the diagnosis of atypical rashes of possible herpetic aetiology in immunocompromised patients, including haemodialysis patients.
Abstract 3820: Reduced migration and enhanced killing of glioblastoma multiforme by mefloquine via alteration of sphingolipid levels
Authors: Natasha Sharma, Heeyon Y. Cho, Simmy Thomas, Thomas C. Chen, Florence M. Hofman, Nicos A. Petasis, Axel H. Schonthal, Stan G. Louie
Journal: Cancer Research (2012)

Abstract Purpose: Glioblastoma multiforme (GBM) is one of the most aggressive and common brain tumors. Current therapy for GBM is limited to surgery, radiation therapy and chemotherapy using temozolomide (TMZ). However, the emergence of resistance to TMZ and the ability of malignant gliomas to migrate away from the primary tumor site often results in recurrence of the tumor and failure of the initial therapy. This dire scenario illustrates the urgent need to identify novel agents that will be effective in TMZ-resistant tumors. In this study, we investigated the anticancer potential of an FDA approved antimalarial drug, mefloquine (MQ), in the in vitro model of GBM. MQ's impact on glioma viability, proliferation and migration was studied in a number of wild type and TMZ-resistant cells lines. We also evaluated the effects of MQ on intracellular levels of sphingolipids, which are bioactive lipids and have been recognized as the mediators of cellular proliferation and invasion in GBM. Method: To study the effect of MQ on TMZ resistance in vitro, we generated TMZ-resistant cell lines from established GBM cells. We evaluated the effects of MQ on cellular viability and proliferation by MTT assay and colony formation assay. Moreover, cell death was determined by analyzing the effect of MQ on various markers of apoptosis (e.g. cleavage of caspase 7 and PARP) using western blot. The effect of MQ on the migration of both TMZ-sensitive and -resistant cells was evaluated using wound healing scratch assay and Boyden chamber. To evaluate the impact of MQ on sphingolipids, we employed a validated LC-MS lipidomic assay to quantify the levels of various sphingolipids. Results: MQ was able to reduce cellular viability and proliferation in both TMZ-sensitive and -resistant GBM cells. MQ exerted its antitumor activity through induction of apoptosis. Our results further demonstrate the ability of MQ to reduce the migration of both TMZ-sensitive and -resistant GBM cell lines. In addition MQ was able to reduce the intracellular levels of sphingosine-1-phosphate (S1P), a pro-survival and pro-migratory sphingolipid and increased the levels of ceramide, a pro-apoptotic sphingolipid. Conclusion: Altogether our results demonstrate the ability of MQ to reduce cellular viability and proliferation and to induce apoptotic cell death in both TMZ-sensitive and -resistant GBM cells. It is conceivable that MQ exerts these effects by altering sphingolipid metabolism. These preliminary data suggests that MQ should be further investigated for cancer therapeutic purposes for TMZ-resistant GBM. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3820. doi:1538-7445.AM2012-3820
Differentiation in vitro of hybrid eosinophil/basophil granulocytes: autocrine function of an eosinophil developmental intermediate.
Authors: J A Boyce, D Friend, R Matsumoto, K F Austen, W F Owen
Journal: The Journal of Experimental Medicine (1995)

Granulocytes with the hybrid characteristics of eosinophils and basophils have been identified in the bone marrow and peripheral blood of humans with myeloid leukemias. We now describe a technique by which such hybrid granulocytes can be developed in vitro from normal cord blood precursors cultured in the presence of recombinant human interleukin (rhIL) 3 (350 pM) and rhIL-5 (200 pM) in a plastic vessel coated with Matrigel. After 14 d in culture, 90 +/- 3% (mean +/- standard error of the mean) of the nonadherent cells cultured in the Matrigel-coated flasks contained both eosinophil and basophil granules, as indicated by staining with Wright's and Giemsa stains. Of the nonadherent cells, 93 +/- 1% contained cyanide-resistant peroxidase, and 88 +/- 2% were toluidine blue-positive, characteristic of eosinophil and basophil granules, respectively. Transmission electron micrographs showed hybrid cells containing ultrastructurally distinct eosinophil granules with developing crystalline cores and basophil granules with reticular structures. These 14-d cord blood-derived cell cultures showed strong hybridization signals for eosinophil-derived neurotoxin by RNA blot analysis and contained 78 ng histamine per 10(6) cells. When the granulocytes were removed from cytokine-containing medium and suspended without Matrigel in RPMI 1640 medium containing 10% fetal calf serum (FCS), more than 80% of the granulocytes excluded trypan blue for as long as 5 d, and 93% had developed into eosinophils at 6 d. Conditioned medium prepared over 48 h from the 14-d cell cultures (hybrid granulocytes) sustained the 4-d viability in vitro of 78% of peripheral blood eosinophils from atopic donors. In comparison, 13% survived in RPMI 1640 containing 10% FCS alone. This viability-sustaining activity was nearly completely neutralized by an anti-granulocyte/macrophage colony-stimulating factor (GM-CSF) antibody and was only minimally reduced by anti-IL-3 or IL-5. Thus, cells possessing both eosinophil and basophil granules by both histochemical and ultrastructural analysis can be developed from normal progenitors in vitro in response to eosinophilopoietic cytokines and Matrigel. Their subsequent spontaneous development into mature eosinophils suggests that hybrid granulocytes are part of a normal developmental sequence during eosinophilopoiesis. Furthermore, these hybrid granulocytes are capable of autoregulation through elaboration of GM-CSF, which sustains their viability.
In Vivo Measurement of Cell-Type-Specific Synaptic Connectivity and Synaptic Transmission in Layer 2/3 Mouse Barrel Cortex
Authors: Aurélie Pala, Carl C.H. Petersen
Journal: Neuron (2014)

Intracellular recordings of membrane potential in vitro have defined fundamental properties of synaptic communication. Much less is known about the properties of synaptic connectivity and synaptic transmission in vivo. Here, we combined single-cell optogenetics with whole-cell recordings to investigate glutamatergic synaptic transmission in vivo from single identified excitatory neurons onto two genetically defined subtypes of inhibitory GABAergic neurons in layer 2/3 mouse barrel cortex. We found that parvalbumin-expressing (PV) GABAergic neurons received unitary glutamatergic synaptic input with higher probability than somatostatin-expressing (Sst) GABAergic neurons. Unitary excitatory postsynaptic potentials onto PV neurons were also faster and more reliable than inputs onto Sst neurons. Excitatory synapses targeting Sst neurons displayed strong short-term facilitation, while those targeting PV neurons showed little short-term dynamics. Our results largely agree with in vitro measurements. We therefore demonstrate the technical feasibility of assessing functional cell-type-specific synaptic connectivity in vivo, allowing future investigations into context-dependent modulation of synaptic transmission.
Accuracy of Administrative Coding for Type 2 Diabetes in Children, Adolescents, and Young Adults
Authors: Erinn T. Rhodes, Lori M.B. Laffel, Tessa V. Gonzalez, David S. Ludwig
Journal: Diabetes Care (2007)

We appreciate that Ding et al. (1) have added to the dialogue regarding the validity of methods that assess diabetes status in research. Our analysis (2) of administrative data showed that among children, adolescents, and young adults in a large children's hospital, the positive predictive value (PPV) for type 2 diabetes of a type 2 diabetes ICD-9-CM code was low (16.0%), whereas the PPV for type 1 diabetes of a type 1 diabetes ICD-9-CM …
Collection of Sputum for Cytologic Examination
Authors: W. O. Umiker, D. R. Korst, R. P. Cole, S. G. Manikas
Journal: New England Journal of Medicine (1960)

A PREREQUISITE for the successful detection of cancer cells in sputum is an adequate specimen, the microscopical criterion for which is the presence of alveolar histiocytes ("dust" cells). Although most patients with disease of the lower respiratory tract cough, their sputum may consist only of saliva, oral squamous cells, mouth organisms and food particles. Other specimens, especially first morning sputum, consist of "postnasal drip" that accumulated during the night and is characterized microscopically by mucopurulent exudate, with or without large ciliated columnar cells from the upper respiratory passages.Most patients who have lung disease can produce suitable specimens after adequate . . .
Endoscopic Diagnosis in Gastroenterology
Authors: Dennis M. Jensen
Journal: JAMA (1983)

ABSTRACT This is an atlas of endoscopic diagnosis in gastroenterology. In separate chapters, Dr Kasugai and his colleagues present techniques, indications, contraindications, and complications for fiberoptic endoscopy of the esophagus, stomach, duodenum, small intestine, colon, and pancreaticobiliary system (endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy).The most appealing aspect of this book is the inclusion of brief case histories (total 141) after each chapter, illustrated with endoscopic color photographs, schematic drawings of the endoscopic pictures, roentgenograms, and macroscopic and microscopic histopathology. With this approach, the authors have greatly facilitated the correlation of endoscopic, clinical, and pathological information for the reader. While there is some variability in the quality of the endoscopic photographs (those of the upper gastrointestinal [GI] tract tend to be better than the colon or small intestine), other illustrations and roentgenograms are superb. All the chapters are clearly written.There are some limitations. The book costs $85; however, this is
The American Physician and the Abortion Problem
Authors: Seymour B. Bronstein
Journal: JAMA (1965)

<h3>To the Editor:—</h3> It is gratifying that the AMA has established a Committee on Human Reproduction and that our Association has recognized the responsibility of physicians to provide information relating to reproduction and population control. These problems require medical assistance in their solution. I hope that the Committee will give consideration in its studies to the problem of abortion. Illegal abortion and the maternal morbidity and mortality associated therewith represents one of the greatest unsolved and neglected public health problems in our country. The hundreds and possibly thousands of deaths annually following illegal abortion goes virtually unnoticed year after year. This callous disregard of a major medical and social problem is a black mark against society and particularly against organized medicine. History will look at the attitudes and practices of physicians of 1965 and regard this maternal mortality as evidence of backwardness and cowardice of the physicians of the mid-twentieth
Attenuation of myocardial acidosis by propranolol during ischaemic arrest and reperfusion: evidence with 31P nuclear magnetic resonance
Authors: G. M PIEPER, G. L TODD, S. T WU, J M SALHANY, F. C CLAYTON, R. S ELIOT
Journal: Cardiovascular Research (1980)

31P nuclear magnetic resonance (NMR) spectroscopy was used to ascertain whether propranolol could reduce the development of myocardial acidosis during periods of ischaemic arrest and reperfusion of isolated, perfused guinea pig hearts. Two groups (35 or 60 min) of global ischaemia and arrest were studied. Cardiac pH progressively declined during ischaemia from a normal of 6.97 ± 0.02 (n = 23) to 6.09 ± 0.04 or 5.96 ± 0.04, respectively. Normalisation of pH following reperfusion occurred only in the 35 min ischaemic hearts. Propranolol (1 mg·litre−1) given prior to arrest significantly reduced the magnitude of developing acidosis regardless of the length of ischaemia. Furthermore, it aided in the normalisation of intramyocardial pH upon reperfusion in both groups. Propranolol significantly reduced the magnitude of phosphocreatine (PCr) loss normally seen during ischaemic arrest alone, but it did not protect against the depletion of ATP. Restoration of PCr during reperfusion was virtually complete in all cases, while transient increases in ATP were seen only in those hearts protected by propranolol. In summary, this NMR study demonstrated the first direct evidence that a significant component of the myocardial acidosis caused by global ischaemia and arrest can be blocked by propranolol.
THE DOCTORATE ADDRESS DELIVERED AT THE COMMENCEMENT OF THE ILLINOIS MEDICAL COLLEGE.
Authors: SETH SCOTT BISHOP
Journal: JAMA (1896)

<i>Members of the Graduating Class:</i>In conferring the degree of Doctor of Medicine upon you to-day, the honor and privileges conveyed with the title are not likely to be underestimated or forgotten. But you should be reminded that in accepting the privileges of physicians, you assume at the same time duties of the gravest nature. Your relations to the members of the community who will entrust themselves to your care are changed. Such relations become as sacred and inviolable as those existing between priest and parishioner—between lawyer and client. Your duties will involve an intimate knowledge of their affairs, their habits and their characters, such as no other professional relation in life conveys. Our laws recognize, protect and dignify this high position which is maintained by every honorable physician. In the safety vaults of your memories will be treasured those confidences and secrets that are poured, confession-like, into every Doctor's
Ethically Increasing the Supply of Transplantable Organs
Authors: Aaron Spital
Journal: Annals of Internal Medicine (2007)

Letters3 April 2007Ethically Increasing the Supply of Transplantable OrgansAaron Spital, MDAaron Spital, MDFrom Elmhurst Hospital Center, Mt. Sinai School of Medicine, Elmhurst, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-7-200704030-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: In his recent editorial (1), Childress adeptly summarized recent Institute of Medicine (IOM) recommendations (2) for increasing the supply of transplantable organs. According to the IOM report, we should continue to rely on public goodwill but should work harder to stimulate it through education, creation of donor registries, and improvement in techniques for obtaining consent. In my opinion, with the notable exception of encouraging donation after cardiac death, the IOM's recommendations are somewhat disappointing because they do not differ fundamentally from previous suggestions. We need a new approach to organ procurement—not more of the same.Let's start ...References1. Childress JF. How can we ethically increase the supply of transplantable organs? [Editorial]. Ann Intern Med. 2006;145:224-5. [PMID: 16880464] LinkGoogle Scholar2. Childress JF, Liverman CT, eds. Organ Donation: Opportunities for Action. Washington, DC: National Academies Pr; 2006:206-8, 226. Google Scholar3. Harris J. Organ procurement: dead interests, living needs [Editorial]. J Med Ethics. 2003;29:130-4. [PMID: 12796426] CrossrefMedlineGoogle Scholar4. Spital A, Erin CA. Conscription of cadaveric organs for transplantation: let's at least talk about it. Am J Kidney Dis. 2002;39:611-5. [PMID: 11877582] CrossrefMedlineGoogle Scholar5. Spital A, Taylor JS. Routine recovery of cadaveric organs for transplantation: consistent, fair, and life saving. Clinical Journal of the American Society of Nephrology. 2007. [Forthcoming]. Google Scholar Author, Article, and Disclosure InformationAuthors: Aaron Spital, MDAffiliations: From Elmhurst Hospital Center, Mt. Sinai School of Medicine, Elmhurst, New York.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHow Can We Ethically Increase the Supply of Transplantable Organs? James F. Childress Ethically Increasing the Supply of Transplantable Organs Mohamed Y. Rady and Joseph L. Verheijde Metrics 3 April 2007Volume 146, Issue 7Page: 537-538KeywordsConflicts of interestFallsTransplantation ePublished: 3 April 2007 Issue Published: 3 April 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Serum Lactic Dehydrogenase Activity and Folate Deficiency in Myelosclerosis and other Haematological Diseases
Authors: A. V. Hoffbrand, S. Kremenchuzky, P. J. Butterworth, D. L. Mollin
Journal: BMJ (1966)

Methods 1. Serum lactic dehydrogenase was determined by the method of Wroblewski and LaDue (1955).All sera were separated one or two hours after the blood was collected, and, if not assayed immediately, were stored at 40 C. until the time of estimation.The storage period was usually less than 24 hours and never more than three days.The enzyme estimation was carried out at 25°C. in a Unicam SP 500 spectrophotometer fitted with a constant-temperature device, and the reaction rate was found to be linear throughout the five-minute period of observation.
Modified Endotracheal Connector
Authors: G. S. A. Knowles
Journal: BMJ (1952)

<h3>Abstract</h3> A randomized cluster, double-blinded, placebo-controlled trial was conducted to estimate protective efficacy of a spatial repellent against malaria infection at Sumba, Indonesia. Following radical cure in 1,332 children aged 6mo-5yrs in 24 clusters, households were given transfluthrin or placebo passive emanators. Monthly blood screening and biweekly human-landing mosquito catches (HLC) were performed during 10-months baseline (June 2015 to March 2016) and a 24-month intervention period (April 2016 to April 2018). Screening detected 164 first-time malaria infections and an accumulative total of 459 infections in 667 subjects in placebo-control households; and 134 first-time and 253 accumulative total infections among 665 subjects in active intervention households. The 24-cluster protective effect of 27.7% and 31.3%, for time to first-event and overall (total new) infections, respectively, was not statistically significant. Purportedly, this due in part to zero to low incidence in some clusters during intervention undermining the ability to detect an effect. Subgroup analysis of 19 clusters where at least one malaria infection occurred showed 36.0% and 40.9% (statistically significant at 1-sided 5% significance level; p=0.0236) protective effect for time to first-event and overall infections, respectively. Primary entomological analysis of impact proved not statistically significant, with indoor and outdoor anopheline HLC reduced by 16.4% and 11.3%, respectively. Among 12 high-risk clusters, a significant impact on infection was detected (about 60% protective efficacy). While this study suggests protective effects of the intervention, additional evidence is required to demonstrate that spatial repellents provide a practical and effective means in reducing malaria transmission.
Defining visuomotor dissociations and an application to the oculomotor system
Authors: Bruce Bridgeman
Journal: Behavioral and Brain Sciences (2004)

The perception/planning–control conception has a direct predecessor in a cognitive/sensorimotor scheme, where the cognitive branch includes Glover's perception and planning functions. The sensorimotor branch corresponds to Glover's control function. The cognitive/sensorimotor scheme, like the perception/planning–control scheme, differentiates between motor planning and direct motor control, which is inaccessible to awareness or to long-term memory.
Synthesis of renin by tubulocystic epithelium in autosomal-dominant polycystic kidney disease
Authors: Vicente E. Torres, Kathleen A. Donovan, Gloria Scicli, Keith E. Holley, Stephen N. Thibodeau, Oscar A. Carretero, Tadashi Inagami, James A. McAteer, Christopher M. Johnson
Journal: Kidney International (1992)