tbuckley/cabot-search huggingface dataset:
Abstract 4773: Synergistic effects of chitosan and docosahexanoic acid on osteopontin expression and secretion in an ovarian cancer cell line, SKOV-3
Authors: Ebonee Williams, Phane Otenyo, Domonique Carr, Antoine Hicks, Daniel Macaulay, Deforest Peterson, Julia Stone, Laura Carson, Gloria C. Regisford
Journal: Cancer Research (2012)

Abstract Current treatment for the deadliest gynecological disease, ovarian cancer, is surgical debulking followed by chemotherapy or radiotherapy, but reoccurrence is still significantly high. Hence, there is a need for alternative treatments, and more specifically a natural therapeutic product. Recent studies have shown that natural products, such as chitosan and omega-3 fatty acids, inhibit the proliferation of cancer cells. Osteopontin (OPN), a cell surface and secretory glycoprotein, has been implicated as an important biomarker for ovarian cancer. Therefore, the objective of this study was to determine the effect of chitosan and DHA on OPN secretion and expression levels in an ovarian cancer cell line, SKOV-3 cells. We hypothesized that chitosan and DHA will decrease OPN expression in a dose-dependent manner. To test our hypothesis, SKOV-3 cells were treated with (a) 0 ng/mL, (b) 1% acetic acid; (c) 250 ng/mL of chitosan, (d) 100 µM of DHA, (e) 250 ng/mL of chitosan + 100 µM of DHA for 24 and 48 hours. Western Blot analysis and immunocytochemistry were performed to observe the expression and localization of OPN, while an ELISA was used to determine OPN secretion. Quantitative RT-PCR was also performed to determine OPN mRNA expression in the treated cells. Osteopontin (OPN) protein was localized on the surface of SKOV-3 cells and its expression decreased in both chitosan and DHA-treated cells. Furthermore in cells treated with both chitosan and DHA, there was an even greater decrease in OPN expression. The synergistic effects of chitosan and DHA suggest that these natural products may serve as potential natural treatment for ovarian cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4773. doi:1538-7445.AM2012-4773
Hail in Silence! Mobile Thrombus in the Aortic Arch
Authors: Yong Hyun Park, Kook Jin Chun, Jeong Su Kim, Sung Gook Song, Dong Cheul Han, Jun Kim, June Hong Kim
Journal: Circulation (2010)

A 41-year-old man was admitted to the emergency de- partment for sudden-onset right hemiparesis.He had no history of diabetes mellitus, hypertension, arrhythmias, or stroke.However, he had a 20-year history of smoking, dyslipidemias, and hypothyroidism (laboratory test on admission revealed elevated thyrotropin [13.16 IU/mL; reference, 0.27 to 4.2], normal T3 [0.84 ng/mL; reference, 0.58 to 1.59], and normal free T4 [0.81 ng/dL; reference, 0.70 to 1.48] levels).Magnetic resonance imaging of the brain revealed newly developed left cerebral infarction (Figure 1A and1B).Brain computed tomographic (CT) perfusion imaging demonstrated perfusion defect in the left middle cerebral artery territory (Figure 1C), and CT angiography revealed total
CATARACT-IN-CAPSULE EXTRACTION BY A NEW MEANS AND A NEW METHOD
Authors: G. C. SAVAGE
Journal: JAMA (1910)

The ideal operation for cataract is the one that insures the removal of the cloudy lens in its capsule. The means and the method that can make this operation easiest and safest are to be desired. At the meeting of this Section one year ago, while listening to Dr. Greene's paper on the Smith operation, it occurred to me that an instrument could be made that would tear loose the ligaments and make the expulsion of the lens in its capsule easy. I immediately made a drawing of the newly thought of instrument, and two days later, in Philadelphia, had one made by Ferguson. The accompanying illustration is a perfect representation of the original instrument, which was briefly described inThe Journallast year,<sup>1</sup>and on which, it seems to me, no improvement can be made. As well shown, it is a right and left-handed instrument. Each end terminates
Morphoea lesions are associated with aberrant expression of membrane cofactor protein and decay accelerating factor in vascular endothelium
Authors: G.T. VENNEKER, P.K. DAS, B. NAAFS, A.J. TIGGES, J.D. BOS, S.S. ASGHAR
Journal: British Journal of Dermatology (2006)

One of the main features of systemic and localized forms of scleroderma is vascular damage, the mechanism of which is not yet understood. Recently, we have shown undetectable or decreased expression of complement regulatory molecules, membrane cofactor protein (MCP) and decay-accelerating factor (DAF), in cutaneous endothelium of patients with systemic sclerosis (SSc). In some patients, CD59 expression in endothelium was also altered. As these molecules protect endothelial cells from damage by autologous complement, their decreased expression could be part of the mechanism of vascular damage in SSc. In the present study, we investigated the expression of MCP, DAF and CD59 in the endothelium of lesional and non-lesional skin of patients with localized morphoea. Normal skin and lesional skin from patients with systemic lupus erythematosus, and three inflammatory diseases, were included as relevant controls. The results showed that the extent of expression of the three molecules in non-lesional skin of patients with morphoea, on all the skin cells and structures, was identical to that of normal skin. In lesional skin, however, the expression of MCP and DAF in endothelium was either undetectable or only present to a very slight degree. CD59 expression in endothelium in lesional skin was normal. No such aberrant expression was observed in the lesions of any of the control diseases. These results indicate a decreased ability of endothelial cells in lesional areas to protect themselves from autologous complement, and this could contribute to vascular damage in morphoea lesions.
Ethnic Differences in the Use of Peritoneal Dialysis as Initial Treatment for End-Stage Renal Disease
Authors: Christie Barker-Cummings
Journal: JAMA (1995)

<h3>Objective.</h3> —To evaluate the influence of ethnicity on the use of peritoneal dialysis (PD) as initial treatment for end-stage renal disease (ESRD) after controlling for other patient characteristics. <h3>Design.</h3> —Inception cohort analysis of incident ESRD patients. <h3>Patients.</h3> —All African-American and white patients (N=10 726) who began treatment for ESRD at dialysis centers in North Carolina, South Carolina, and Georgia and reported to ESRD Network 6 between January 1,1989, and December 31, 1991. <h3>Main Outcome Measure.</h3> —Odds ratios (ORs) of the association between ethnicity and PD as initial treatment modality. <h3>Results.</h3> —African-American patients were 56% less likely than whites to use PD (OR, 0.44; 95% confidence interval [CI], 0.40 to 0.49). This difference persisted (OR, 0.45; 95% CI, 0.38 to 0.52) after multivariable adjustment for age, education, social support, home ownership, functional status, albumin level, hypertension, history of myocardial infarction, peripheral neuropathy, and comorbid diabetes. <h3>Conclusions.</h3> —Ethnic differences in initial PD use cannot be explained by many demographic, socioeconomic, and comorbid factors associated with the use of PD as initial treatment for ESRD. (<i>JAMA</i>. 1995;274:1858-1862)
Whole-body in-vivo neutron activation analysis in assessing treatment of renal osteodystrophy with 1-alpha-hydroxycholecalciferol.
Authors: R B Naik, P Gosling, C P Price, B H Robinson, J T Dabek, D A Heath, H M James, J A Kanis, R Smith
Journal: BMJ (1976)

Four selected adults with different patterns of osteodystrophy receiving regular dialysis were treated with 1-alpha-hydroxycholecalciferol (1-alpha-OHD3) 0-5-2 mug/day for 10 to 12 months. In two patients, one with osteitis fibrosa and the other with osteomalacia, significant biochemical, radiological, and histological improvements occurred, and total body calcium measured by in-vivo neutron activation analysis increased. In two patients, in whom there were no increases of whole-body calcium, neither biochemical improvement nor healing of bone lesions occurred during the study; in one of these patients the effect of 1-alpha-OHD3 on bone resorption may have contributed to loss of body calcium and deterioration of bone disease. 1-alpha-OHD3 may therefore be a valuable adjunct in the treatment of only some patients with renal osteodystrophy. Whole-body in-vivo neutron activation seems to provide a sensitive and non-invasive index of early response to treatment.
Incidental Parathyroid Adenoma Mimicking Tumor Recurrence in a Patient With Follicular Thyroid Carcinoma
Authors: Juri Ruf, Daniel Seehofer, Bahram Nadjari, Holger Amthauer, Nada Rayes
Journal: Clinical Nuclear Medicine (2006)

We report the case of a 59-year-old woman with a history of follicular thyroid cancer who had reoperation for suspected local tumor recurrence as laboratory (tumor marker), imaging findings (ultrasound, I-131 scintigraphy and Tc-99m-MIBI scintigraphy), and also fine needle aspiration (FNA) cytology were equivocal. However, postoperative histopathology revealed a parathyroid adenoma.
Grading evidence and recommendations for clinical practice guidelines in nephrology. A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
Authors: K. Uhlig, A. MacLeod, J. Craig, J. Lau, A.S. Levey, A. Levin, L. Moist, E. Steinberg, R. Walker, C. Wanner, N. Lameire, G. Eknoyan
Journal: Kidney International (2006)
Estimation of lead-time bias and its impact on the outcome of surveillance for the early diagnosis of hepatocellular carcinoma
Authors: Alessandro Cucchetti, Franco Trevisani, Anna Pecorelli, Virginia Erroi, Fabio Farinati, Francesca Ciccarese, Gian Lodovico Rapaccini, Mariella Di Marco, Eugenio Caturelli, Edoardo G. Giannini, Marco Zoli, Franco Borzio, Giuseppe Cabibbo, Martina Felder, Antonio Gasbarrini, Rodolfo Sacco, Francesco Giuseppe Foschi, Gabriele Missale, Filomena Morisco, Gianluca Svegliati Baroni, Roberto Virdone, Mauro Bernardi, Antonio D. Pinna
Journal: Journal of Hepatology (2014)
Whole Body Computerized Tomography: Practical Image Analysis
Authors: Mark J. Goldman
Journal: JAMA (1984)

This brief text is an excellent primer on body computed tomography (CT), primarily for the nonradiologist with an interest in body CT. The first section is a brief, comprehensible treatise on the basic mechanics of CT. Next is an anatomic outline with normal CT images of the chest and abdomen accompanied on each page by a frontal line drawing of the major vessels and viscera, which is a very useful reference guide for the level of the CT section. Matching anatomic drawings of each CT image are well labeled. However, the accompanying key to the anatomy uses Latin terminology, which may be slightly confusing for American readers. Several sections then follow on technical details. Computed tomographic techniques are somewhat dogmatically presented, leaving little room for variation or innovation. The remainder of the book is devoted to specific anatomic areas with several well-demonstrated examples of important pathological processes for each area.
Dose-Response Relation Between Physical Activity and Fitness
Authors: I-Min Lee
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effectiveness of a Regional Bone Marrow Donor Program
Authors: Jeffrey McCullough
Journal: JAMA (1988)

Because many potential bone marrow transplant patients lack HLA-matched siblings, there is growing interest in carrying out transplantations using matched, unrelated volunteer donors. We developed a local registry of 2147 informed donors who consented to be listed in the Bone Marrow Donor Registry. This registry was used to carry out 420 donor searches for 351 patients. The initial computer search involved matching for HLA-A and HLA-B locus antigens only because most donors had not been typed for HLA-DR antigens. Depending on the degree of HLA-A and HLA-B antigen mismatching allowed, suitably matched (HLA-DR-identical, mixed lymphocyte culture nonreactive) donors were located for 6% to 16% of patients. This resulted in 13 bone marrow transplants. This study shows that a small, local bone marrow donor registry can locate donors for a few patients; however, a large network involving an expanded number of donors will be necessary to allow an extensive evaluation of unrelated bone marrow transplantation.
Effects of PBB on cattle. II. Gross pathology and histopathology.
Authors: P D Moorhead, L B Willett, F L Schanbacher
Journal: Environmental Health Perspectives (1978)

Toxicosis was induced in pregnant Holstein heifers by feeding FireMaster BP-6 (polybrominated biphenyls) in daily oral doses of 25 g/head/day for 33--60 days. The individual heifers were dosed until each became moribund (days 33, 36, 39, 40, 41, or 66), at which time they were necropsied. Gross findings included dehydration, subcutaneous emphysema and hemorrhage, atrophy of the thymus, fetal death with concomitant necrosis of cotyledons, thickened wall of the gallbladder, inspissated bile, edema of abomasal folds, mucoid enteritis, linear hemorrhage and edema of the rectal mucosa, and secondary pneumonia. The livers were enlarged approximately 40%. Kidneys were approximately double the normal size and were pale tan to grey in color. The perirenal lymph nodes were enlarged and edematous. Microscopic changes were the most marked in the kidneys, gallbladder and eyelid. Extreme dilatation of collecting ducts and convoluted tubules with epithelial degenerative changes of cloudy swelling, hydropic degeneration and separation from the basement membrane were principal changes in the kidney. Hyperkeratosis with accumulations of keratin in hair follicles of the epidermis and squamous metaplasia with keratin cysts in the tarsal glands were characteristic findings in sections of eyelids. Moderate to marked hyperplasia and cystic dilatation of the mucous glands in the lamina propria were common changes in the gallbladder. Foci of fatty degeneration and glycogen depletion were observed in liver sections. Necropsy of heifers immediately after 60 days exposure to 0.25 and 250 mg/head/day of PBB showed no gross or histopathological signs indicating toxicosis. Following parturition, at approximately 220 days after the PBB doses, heifers from the 0.25 and 250 mg/head/day groups and their calves were necropsied and displayed no signs of toxicosis.
Abstract 4613: A role of integrin-associated CD151 in human ovarian cancer
Authors: Hongyan Jin, John T. Hoff, Xinyu Deng, Ronny I. Drapkin, Xiuwei H. Yang
Journal: Cancer Research (2012)

Abstract Despite being implicated in multiple types of human epithelia-origin cancer, laminin-binding (LB) integrins (e.g., α3α1 and α6β4) have rarely been investigated for their roles in human ovarian tumors. More recently, we and others have shown that CD151, a member of the tetraspanin family, not only forms tight surface complexes with these adhesion receptors, but also mediates the malignancy of human carcinomas largely in a LB integrin-dependent manner. Here we report our studies on the role of CD151 in human ovarian cancer. Initially, we stained human ovarian tumor tissue microarrays with CD151-specific antibody. Our data showed that the majority of ovarian tumors exhibited a reduced expression of CD151 protein, compared to the fallopian tube, implying a putative suppressing role of this tetraspanin in ovarian cancer. With this hint we next evaluated the impact of CD151 ablation on the behaviors and proliferation of cultured human ovarian cancer cells. While CD151 removal had a minimal impact on cell motility or invasion, it markedly enhanced cell proliferation. Also, CD151-deficeint cells appeared to have reduced cell-cell contacts, suggestive of epithelial-mesenchymal transition (EMT)-like changes. However, there was no dramatic difference in the surface expression of E-cadherin protein, according to our FACS analyses. To substantiate these observations, we also injected ovarian cancer cells with or without CD151 knockdown into immuno-deficient nude mice subcutaneously or orthotopically (intra-peritoneal). Results from these ex vivo analyses showed that disruption of CD151 accelerated ovarian tumor growth and production of ascites fluid in mice, further supporting a role of CD151 in ovarian tumor progression. While tumors in the control group had homogenous epithelial-like appearance, those derived from CD151-ablated cells exhibited mucin-related vacuoles and diverse morphologies. Our subsequent DNA array and protein analyses indicated that there was indeed a marked increase in the expression of a mucin family member in CD151-deficient tumor cells. Collectively, these results provide strong evidence that CD151 suppresses human ovarian cancer progression by regulating tumor cell proliferation and extracellular microenvironment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4613. doi:1538-7445.AM2012-4613
Ineffectiveness of haemodialysis in atropine poisoning.
Authors: D P Worth, A M Davison, T G Roberts, A M Lewins
Journal: BMJ (1983)

CommentOur findings show that higher concentrations of lactate occur in septic bursal fluid when compared with non-septic samples.The series also included a non-infected specimen with an unexplained high lactate value, and this parallels the results of other workers"5 with o.her body fluids.For example, in a recent study of over 300 synovial fluid samples2 raised concentrations were recorded in 13 out of 56 cases of rheumatoid arthritis and four out of 58 cases of osteoarthrosis.Normal values were not found in any untreated septic specimen, and this was also true in our study.The UV lactate test is simple to perform and gives a result in 15- 20 minutes at a cost of 40p per test.It is thought that its value lies in the rapid exclusion rather than the diagnosis of sepsis, and it can be usefully performed before the administration of local treatment.We thank the physicians and surgeons of the Nuffield Orthopaedic Centre, Oxford, for allowing us to study patients under their care.We also thank Professor R B Duthie and Dr A G Mowat for advice in preparing the manuscript, and BCL for providing the UV lactate kits.
Amyloid deposition in intrahepatic large bile ducts and peribiliary glands in systemic amyloidosis
Authors: Motoko Sasaki, Yasuni Nakanuma, Tadashi Terada, Masahiro Hoso, Katsuhiko Saito, Morimoto Hayashi, Hiroshi Kurumaya
Journal: Hepatology (1990)

Amyloid deposition in the hepatic parenchyma and portal tracts in the liver is well known in systemic amyloidosis. We recently experienced an autopsy case of systemic amyloidosis presenting the amyloid deposits in the intrahepatic biliary tree. This experience prompted us to survey 19 autopsy cases of systemic amyloidosis. Amyloid deposition was found just under the lining epithelium of the intrahepatic large bile duct in 10 of 19 cases and around the peribiliary glandular acini in 7 of the 19 cases, respectively. Amyloid deposition in the intrahepatic large bile duct and peribiliary glands was positively correlated with the degree of amyloid deposition in the liver but not with type of amyloid protein. Double-staining of amyloid and vascular endothelium disclosed that amyloid deposition was more closely related to the inner part of the peribiliary vascular plexus and to the vascular plexus encircling the peribiliary glands than the lining biliary epithelium and peribiliary glandular acinar cells themselves. The exact pathogenesis of amyloid deposition in these anatomical components, however, remains unclear. Although our cases failed to show any overt clinical symptomatologies related to amyloid deposition in these biliary components, it seems conceivable that more massive amyloid deposition in these anatomical components could give rise to some clinical symptoms.
180?? SPECT of the Spine in Patients with Low Back Pain
Authors: EINAT EVEN-SAPIR, DAVID C. BARNES, SI??N E. ILES, RICHARD C. NICKERSON
Journal: Clinical Nuclear Medicine (1993)

Single-photon emission computed tomography has been proven to detect more abnormalities than planar bone scintigraphy in patients with low back pain (LBP). Both 180° and 360° acquisitions were performed in 24 patients with LBP to determine whether the shorter 180° posterior SPECT is as accurate for abnormality detection as 360° acquisition. The vertebral bodies and posterior elements of 193 vertebrae were scored on a fivepoint score (1 = normal, 5 = abnormal), independently by three experienced physicians, on three separate reconstructed image sets: standard, filtered, back projection 360° acquisition, distance-weighted 360° acquisition, and standard, filtered, back projection 180° acquisition. With one exception, no statistically significant difference in score was found between 180° and 360° images. For one observer, the mean score of the posterior elements was higher on 180° compared to 360° standard images. These results indicate that 180° acquisition SPECT may be used for abnormality detection in patients with LBP.
Use of lung centile charts in cystic fibrosis.
Authors: M B Mearns
Journal: Thorax (1972)

Proceedings of the Thoracic Society and pressure measurements were obtained before giving the frusemide intravenously and the changes were followed over a six-hour period in 20 patients.Measurement of dead space-tidal volume ratio and venous admixture was made in 11 patients.Changes in gas exchange were correlated with change in cardiac output.