tbuckley/cabot-search huggingface dataset:
Atheromatous Ulceration of the Heart: Perforation: Sudden Death
Authors: D. E. Anderson
Journal: BMJ (1901)

the seat " as if in a fit," was at once carried inside and laid on a couch.She was at once seen by the doctor, and found to be dead.Necropsy.-This was performed next day.On opening the pericardium a large amount of clot was found lying in the anterior surface of the heart and distending the pericardium.The heart was fatty as a whole, and sowed two medium-sized milk spots on the left ventricle.At a distance of I inch from the apex, on the anterior aspect of the left ventricle, was an area reddish-purple in colour from effused blood, in the centre of which was a small irregular tear about inch in length.On inserting a probe it was found to lead upwards and inwards into the cavity of the left ventricle, about 2 inch from the interventricular septum.Otherwise there was nothing of note, except that the whole heart showed marked fattv change; it weighed 9 ozs.As regards the other organs.there was little of interest; the lungs were emphysematous, the liver and kidneys were somewhat fatty, and the brain showed signs of degeneration.
Abnormal left ventricular function in patients with mitral stenosis improves following valvuloplasty
Authors: Prabodh M. Mehta, Joshua Wynne, Vincent P. Reyes, B.Soma Raju, D.N. Kumar, K. Srinath, Priscilla Peters, Zoltan G. Turi
Journal: Journal of the American College of Cardiology (1991)
Shortage of psychiatric beds exists in Staffordshire too
Authors: R E Hodgson, A P Boardman
Journal: BMJ (1996)

in those dying of cardiac causes compared with those who survived (0.11 (0.07) and 0.05 (0.02) ms"2 respectively, P<0.001).However, heart rates were similar in the two groups (66 (12) beats/minute in survivors and 66 (13) beats/ minute in those who died).Although there are methodological problems with qualitative measurement of QTc dispersion, previous work has shown that variation in interlead measurements far outweigh inaccuracies introduced by any other factor, including interobserver and intraobserver variation.2In our study the intraobserver and interobserver vari- ability expressed in absolute values was of the order of 1 1 ms"2 and 16 ms"/2 respectively, suggesting that the differences in QTc dispersion between patient groups cannot be explained by variability in measurement.In fact, we reported coefficients of variation on page 875 of our article.The study by Agha W Haider and Saba Naz showing reduced QTc dispersion in patients with preinfarction angina warrants further investigation.Although preinfarction angina might confer some early benefit in hospital, it tends to be associated with more recurrent ischaemia and a worse longer term outcome.3A recent study showing increased QT dispersion in diabetic patients with autonomic dysfunction4 suggests that measurement of QT dispersion in this group of patients may be a cheap and valuable tool for detecting patients at increased risk of sudden cardiac death, as suggested by Gyorgy Jermendy.
6.6-Hour Inhalation of Ozone Concentrations from 60 to 87 Parts per Billion in Healthy Humans
Authors: Edward S. Schelegle, Christopher A. Morales, William F. Walby, Susan Marion, Roblee P. Allen
Journal: American Journal of Respiratory and Critical Care Medicine (2009)

Rationale: Identification of the minimal ozone (O3) concentration and/or dose that induces measurable lung function decrements in humans is considered in the risk assessment leading to establishing an appropriate National Ambient Air Quality Standard for O3 that protects public health.Objectives: To identify and/or predict the minimal mean O3 concentration that produces a decrement in FEV1 and symptoms in healthy individuals completing 6.6-hour exposure protocols.Methods: Pulmonary function and subjective symptoms were measured in 31 healthy adults (18–25 yr, male and female, nonsmokers) who completed five 6.6-hour chamber exposures: filtered air and four variable hourly patterns with mean O3 concentrations of 60, 70, 80, and 87 parts per billion (ppb).Measurements and Main Results: Compared with filtered air, statistically significant decrements in FEV1 and increases in total subjective symptoms scores (P < 0.05) were measured after exposure to mean concentrations of 70, 80, and 87 ppb O3. The mean percent change in FEV1 (±standard error) at the end of each protocol was 0.80 ± 0.90, −2.72 ± 1.48, −5.34 ± 1.42, −7.02 ± 1.60, and −11.42 ± 2.20% for exposure to filtered air and 60, 70, 80, and 87 ppb O3, respectively.Conclusions: Inhalation of 70 ppb O3 for 6.6 hours, a concentration below the current 8-hour National Ambient Air Quality Standard of 75 ppb, is sufficient to induce statistically significant decrements in FEV1 in healthy young adults.
“Endoscopy Friendly” Resection Technique of Choledochal Cysts
Authors: D. Henne-Bruns, B. Kremer, F. Thonke, H. Grimm, N. Soehendra
Journal: Endoscopy (1993)

The resection of a choledochal cyst was performed in two patients (22 and 31 years old, both type Todani IVa). Reconstruction of the biliary-intestinal drainage was performed by interposition of a 15 cm jejunal segment between the liver hilum and duodenum. In both patients, hepatico-jejunostomy could be endoscopically evaluated 5-6 months after the operation, showing patent anastomoses without any signs of reflux or cholangitis.
The inhibition by interleukin 1 of MSC chondrogenesis and the development of biomechanical properties in biomimetic 3D woven PCL scaffolds
Authors: Paul H. Ousema, Franklin T. Moutos, Bradley T. Estes, Arnold I. Caplan, Donald P. Lennon, Farshid Guilak, J. Brice Weinberg
Journal: Biomaterials (2012)
Flexions of the Uterus
Authors: A. B. R. Myers
Journal: BMJ (1886)

ing apparatus be applied during the medical examinati6n, so as to give a normal acuteness of function.But this full perception may not be present a few hours afterwards, and may be concurrent with tissue changes of a kiad which should preclude the acceptance uftie can- didate, The spectacles are apparent to all, and will, as a rule, remedy the defective refraction at all times ; but the changed tension, and the means of effecting it, are discoverable only by an expert, and may be used only on the occasion of the pass-examination.
Abstract LB-165: Safety and pharmacokinetics of liposomal curcumin in healthy subjects:A randomized placebo-controlled double blind first-in human study.
Authors: Angela Storka, Michael Wolzt, Brigitta Vcelar, Gordon Bolger, Muhammed Majeed, Lawrence Helson
Journal: Cancer Research (2013)

Abstract Purpose: Curcumin exerts anti-proliferative and pro-apoptotic effects against various tumors in vitro and in vivo, and it has been found to suppress carcinogenesis in various organs. A liposomal curcumin formulation was developed enabling intravenous application. Methods: 50 healthy male or female subjects between 18 and 45 years were allocated to receive single ascending doses of liposomal curcumin as a continuous infusion over 120 min. Dose levels ranged from 10 to 400 mg/m2. Within each dose group one subject was randomized to receive placebo. A premedication of intravenous diphenhydramine and dexamethasone or diphenhydramine alone was administered to prevent hypersensitivity reactions. Pharmacokinetic assessments included plasma and urine levels of Curcumin and tetrahydrocurcumin (THC), the active metabolite of Curcumin and were analyzed by a validated LC/MS/MS method. Safety assessments included monitoring for adverse events, laboratory safety parameters with special focus on hemolysis, vital signs and ECG. Results and Conclusions: Liposomal curcumin infusions were tolerated without clinical symptoms. At the maximum tolerated dose of 400 mg/m2 of liposomal curcumin, transient increases in erythrocyte mean cell volume, echinocyte formation, and increased plasma lactate were observed. Markers of hemolysis (HBDH, potassium, haptoglobin, LDH, erythrocytes, Hb) did not change significantly, however, a tendency of erythrocyte loss (-0.5 T/l) was observed. At a dose of 120 mg/m2 intermittent echinocyte formation of some erythrocytes was evident. Curcumin and THC levels were established rapidly forming a plateau during infusion with Cmax for curcumin ranging between 42 ± 22 and 2359 ± 412 ng/mL for doses of 10 to 400mg/m2, respectively. Cmax for THC was 7.1 - 15.8-fold lower than Cmax of curcumin. Upon termination of infusion Curcumin and THC were rapidly cleared from plasma with a mean residence time of 0.62 hr for curcumin and 1.69 hr for THC. Urinary curcumin levels accounted for &amp;lt;0.12% of total systemic clearance.Conclusions: Relevant plasma levels of Curcumin were achieved by infusion of liposomal curcumin over 120 min. A continuous infusion (eg 24h) seems appropriate to achieve sustained exposure to curcumin. 120 mg liposomal curcumin/m2 is proposed as safe starting dose for phase I studies in patients with solid tumors. Citation Format: Angela Storka, Michael Wolzt, Brigitta Vcelar, Gordon Bolger, Muhammed Majeed, Lawrence Helson. Safety and pharmacokinetics of liposomal curcumin in healthy subjects:A randomized placebo-controlled double blind first-in human study. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-165. doi:10.1158/1538-7445.AM2013-LB-165
Modeling a theory without a model theory, or, computational modeling “after Feyerabend”
Authors: Arthur M. Jacobs, Jonathan Grainger
Journal: Behavioral and Brain Sciences (1999)

Levelt et al. attempt to “model their theory” with weaver++. Modeling theories requires a model theory. The time is ripe for a methodology for building, testing, and evaluating computational models. We propose a tentative, five-step framework for tackling this problem, within which we discuss the potential strengths and weaknesses of Levelt et al.'s modeling approach.
Prognostic value of the galactose test in predicting survival of patients with cirrhosis evaluated for liver transplantation
Authors: Francesco Salerno, Gianmario Borroni, Pamela Moser, Angelo Sangiovanni, Piero Almasio, Gabriele Budillon, Gaetano Capuano, Maurizio Muraca, Giulio Marchesini, Giulio Marchesini, Mauro Bernardi, Giorgio Marenco, Gianpaolo Molino, Lorenzo Rossaro, Antonio Solinas, Antonio Ascione
Journal: Journal of Hepatology (1996)
NHS Logistics staff plan strike
Authors: Andrew Cole
Journal: BMJ (2006)

The NHS was this week facing its first national strike in 18 years, as supplies staff throughout England voted to take industrial action in protest at the privatisation of the supply agency NHS Logistics.

The first 24 hour strike was due to start at 10 pm last Thursday, 21 September, with another one day strike planned next week and further industrial action to follow. Unison, the union representing most of the organisation's 1300 staff, is also calling for a judicial review into how the contract was awarded.

The action, which could lead to cancelled operations, according to …
The Plight of Civil Defense
Authors: F. J. Ingelfinger
Journal: New England Journal of Medicine (1971)

Are proposals to control biological warfare merely "cosmetic adornment" to conceal the stalemate of disarmament talks? Joshua Lederberg, Stanford's distinguished geneticist, hopes not. The implements of biological warfare, he fears, have the potential to inflict a "virological Hiroshima."1 To mitigate, if possible, such a catastrophe, the Army's Medical Institute of Infectious Diseases continues its labors, unclassified for the past four years. Elsewhere in this issue, Colonel Crozier, the Institute's C.O., describes the tasks the health professions might face if an enemy mounted a successful biological attack against this country. Colonel Crozier's tone is reassuring, but the bare facts of his . . .
Circulatory Support by Pump-Oxygenator in Experimental Ventricular Fibrillation and Acute Left Heart Failure induced by Coronary Artery Ligation
Authors: E. Proctor, T. A. Kowalik
Journal: Cardiovascular Research (1967)

Sixteen cases of intractable ventricular fibrillation and four cases of acute left heart failure were produced in 20 dogs by coronary artery ligation. Circulatory support via peripheral cannulation, using a bloodless-prime pump-oxygenator, enabled 15 animals to regain control of their circulation. Factors involved in support during myocardial ischaemia are discussed.
Analysis of ERBB Ligand-Induced Resistance Mechanism to Crizotinib by Primary Culture of Lung Adenocarcinoma with EML4-ALK Fusion Gene
Authors: Madoka Kimura, Hiroko Endo, Takako Inoue, Kazumi Nishino, Junji Uchida, Toru Kumagai, Yoji Kukita, Kikuya Kato, Fumio Imamura, Masahiro Inoue
Journal: Journal of Thoracic Oncology (2015)
A patient who changed my practice: A unique free lunch
Authors: B N Nayak
Journal: BMJ (1997)

In 1973 I was appointed as the only consultant physician in the elderly in an area with a population of 200 000, 10% of whom were over the age of 65. In those days a consultant for the elderly was hailed as a messiah by the public, as well as by the general practitioners. I soon discovered that I was inundated with requests for home visits. Many of these cases …
RDX Binds to the GABA <sub>A</sub> Receptor–Convulsant Site and Blocks GABA <sub>A</sub> Receptor–Mediated Currents in the Amygdala: A Mechanism for RDX-Induced Seizures
Authors: Larry R. Williams, Vassiliki Aroniadou-Anderjaska, Felicia Qashu, Huckelberry Finne, Volodymyr Pidoplichko, Desmond I. Bannon, Maria F. M. Braga
Journal: Environmental Health Perspectives (2010)

Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a high-energy, trinitrated cyclic compound that has been used worldwide since World War II as an explosive in both military and civilian applications. RDX can be released in the environment by way of waste streams generated during the manufacture, use, and disposal of RDX-containing munitions and can leach into groundwater from unexploded munitions found on training ranges. For > 60 years, it has been known that exposure to high doses of RDX causes generalized seizures, but the mechanism has remained unknown.
Cor triatriatum with pericardial agenesis
Authors: M. J. Martinez, J. S. F. Vazquez, R. G. Bosque, J. J. P. Alvarez, R. A. Sanchez
Journal: Thorax (1969)

A case of cor triatriatum associated with pericardial agenesis, which was successfully treated, is reported. Details of the clinical picture and surgical treatment are given, with emphasis on the good prognosis which results when the diagnosis is made before attempting surgical correction.
Hamster-hair hypersensitivity.
Authors: H K Lim
Journal: BMJ (1971)

Diagnosis of Appendicitis SnM,-I was interested in the simple and practical points Mr. G. D. F. McFadden (13 November, p. 430) mentions in connexion with the diagnosis of appendicitis.But he states that he has failed to see in print that coughing often causes pain in acute appendicitis.In recent editions of Short Practice of Surgery this test has been described, and in the last edition reference is made on page 984.'The other points mentioned in the letter are also very useful guides in the diagnosis of acute appendicitis.-Iam, etc.,
A CASE OF SPLENIC LEUKAEMIA COMPLICATED WITH GOUT AND ALBUMINURIA
Authors: G. Parker
Journal: BMJ (1907)

INSTANCES of leukaemia with fulminating attacks of uratosis are sufficiently rare to justify an account of a well-marked case.The patient, aged, 35, a fitter by trade, has been under treatment for eighteen months for splenic leukaemia with frequently-recurring joint troubles.In May, 1901, he was attacked by malaria while at a port in the United States.A year or two afterwards he was laid up suddenly with pains in the knee which came on after a heavy turn of night work.In 0anuary, 1905, he was admitted as an in-patient at the General Hospital, Bristol, with pyrexia, joint pains, marked anaemia andtreathlessness.The big toe, ankle, and right knee were red, painful, and swollen, while the wrist, elbow, and fingers were also slightly affected.The urine was 1010, acid, and showed a trace of albumen, but no sugar.The retinal discs were normal.The spleen reached below the umbilicus, and a. blood count showed red celis 2,610,000, white 223,200, and numerous myelocytes.There was a systolic murmur at the apex of the heart.The lungs were normal except for slight dullness at the bases.There was no tenderness over the sternum.Under treatment by sodium cacodylate the red cells rose by March 21st to 3,260,000, the white fell to 71,000.The haemo- globin reached 48 per cent., but themyelocytes remained ashigh as 26 per cent.Treatment by the Roentgen rays was kindly undertaken by Dr. W. Kenneth Wills, and steady improvement followed.The spleen decreased in size, the blood became practically normal exoept that 3.2 per cent. of myelocytes were still present, and In June he resumed work, but .came up for the x ray treatment periodically till November.In 'ebruary.1906, he relapsed, and again came under treatment; the leuco- cytes now reached 134,000 and the myelocytes 27 per cent.By April the white cells had fallen to 33,000 and the myelocytes to 12 per cent.The spleen later on diminished and could no longer be felt below the ribs.Frequent slight attacks of arthritis have occurred during all
Lymphocytic interstitial pneumonia associated with common variable immunodeficiency resolved with intravenous immunoglobulins
Authors: N Arish, R Eldor, Y Fellig, N Bogot, U Laxer, U Izhar, A Rokach
Journal: Thorax (2006)

Lymphocytic interstitial pneumonia (LIP) is a rare form of interstitial lung disease. A few case reports have described an association with common variable immunodeficiency (CVID). Corticosteroids are usually used to treat symptomatic patients but their efficacy has never been studied in a controlled trial. We describe a patient with LIP and CVID who was treated monthly with intravenous immunoglobulins (IVIG) without steroids. The patient improved dramatically. We believe that, in selected cases of LIP and immunodeficiency, IVIG given monthly should be considered as the only treatment without adding steroids.
Hepatic Hypoglycemia
Authors: Sherman M. Mellinkoff, Philip A. Tumulty
Journal: New England Journal of Medicine (1952)

MANN'S1 classic experiments in 1921 first demonstrated that a normal concentration of blood sugar in the hepatectomized animal can be maintained only by a constant infusion of glucose. Spontaneous hypoglycemia has been described in man in cases of obvious liver damage due to cirrhosis, viral hepatitis, chemical poisoning, carcinoma and other processes.2 Nevertheless, experience with various forms of liver disease at the Johns Hopkins Hospital indicates that episodes of hypoglycemia are frequently overlooked. Furthermore, it is not well appreciated that hepatic hypoglycemia may occur in the absence of other apparent evidence of impaired liver function. Conn et al.3 first made . . .
PTU-094 Do We Need Post Infliximab Infusion Monitoring?
Authors: K Robinson, A Wright, M McAlindon, A Lobo
Journal: Gut (2014)

<h3>Introduction</h3> Infliximab is used in the treatment of inflammatory bowel disease. It is administered as an intravenous infusion over 2 h with a 2 h monitoring period. Accelerated infusions have been shown to be safe and well tolerated,<sup>1</sup> reducing nursing time and increasing patient satisfaction.<sup>2</sup> It has been suggested that post infusion monitoring may not be necessary,<sup>3</sup> and it was our aim to establish this. <h3>Methods</h3> 310 infusions were administered to 103 patients over 6 months (January to July 2013). Infusions 1–4 were administered over 2 h with 2 h monitoring, 5–9 over 1 h with 1 h monitoring, and 10 onwards over 30 mins with no monitoring. A reaction was classified as mild if no action was required and severe if symptoms required immediate action or treatment withdrawal. A drop in systolic BP of ≥20 mm/Hg was recorded. Treatment of reaction and outcome were documented, including occurrence during or post infusion. Details of any delayed reactions post discharge were obtained from patient notes. <h3>Results</h3> Of 41 patients receiving infusions 1–4, 2 patients (4.87%) had an infusion reaction. One mild, and one severe. Both occurred during the first infusion. Both had previously been treated with infliximab. In 35 patients receiving infusions 5–9, 1 patient (2.86%) experienced a mild reaction during infusion 7, then a severe reaction during infusion 9. No infusion reactions were observed during infusions 10+ (122 infusions in 37 patients). 11 patients had infusions 10+ over 1–2 h due to side effects with accelerated infusions or 10 mg/kg dose. These patients were not monitored post infusion. One patient was hospitalised due to a delayed reaction one week after infusion 1 (previous infliximab treatment 108m). No side effects were observed during the infusion or monitoring period. No reactions were recorded during the monitoring period in any of the treatment groups. One patient had a drop in systolic BP (22 mg/Hg) during the monitoring period of their 5<sup>th</sup> infusion. No action was taken and the patient was discharged. <h3>Conclusion</h3> This audit has demonstrated that post infliximab monitoring is not necessary. We estimate that this would save 494 h of patient and nurse time per annum at our centre. <h3>References</h3> Donnellan CF, <i>et al</i>. Accelerated infliximab infusions are safe and well tolerated in patients with inflammatory bowel disease. <i>Eur J Gastroenterol Hepatol</i> 2009;21(1):71–75 Saxena P, <i>et al</i>. Safety and cost benefit of an accelerated infliximab infusion protocol in the treatment of ambulatory patients with inflammatory bowel diseases. <i>Expert Opin Biol Ther</i> 2013 Dec 21 [Epub ahead of print] Bhat S, <i>et al</i>. Are accelerated infliximab infusions safe in patients with inflammatory bowel disease? <i>Inflammatory Bowel Disease</i> 2010 Nov, 16 11;1922–5 <h3>Disclosure of Interest</h3> None Declared.
The Making of a Surgeon
Authors: M. Therese Southgate
Journal: JAMA (1971)

At its best this book is ersatz autobiography, liberally salted with expletives meant to give it the "colloquial" flavor. At its worst it is an arrogantly told "success story" of how one man survived the pyramid system of surgical residency training at Bellevue Hospital. Designed ostensibly to engage the sympathies of the layman, to whom it is directed, the book exploits rather than amuses or enlightens. The anecdotes, meant to be blood-and-guts humor or stark tragedy, come off as merely pathetic. The stark tragedy is there, all right, but it is the tragedy of the system vs the patient, in which, even after four years of preparation, intern and resident still fail to realize that the physician exists for the patient not vice versa. In terms of literary style this reviewer suspects that the book was not "written" at all. It was "produced." Perhaps a little article by Dr. Nolen
Role of Helicobacter pylori in Conjunctival Mucosa-Associated Lymphoid Tissue Lymphoma
Authors: Nicolai C. Sjö, Pia Foegh, Birgitte R. Juhl, Hans-Olof Nilsson, Jan U. Prause, Elisabeth Ralfkiær, Torkel Wadström, Steffen Heegaard
Journal: Ophthalmology (2006)
43 INTERLEUKIN-28B GENE POLYMORHISM MAY AFFECT THE NATURAL COURSE OF HEPATITIS B AND DELTA VIRUS INFECTIONS
Authors: A.M. Bozdayi, T. Ozturk, S. Altuntas, S.C. Karatayli, E. Karatayli, C. Inci, K. Cinar, R. Albayrak, M. Ozkan, Y. Kendal, R. Idilman, C. Yurdaydin
Journal: Journal of Hepatology (2012)