The Latex-fixation Test in Patients with Liver Disease
Authors: EDWARD C. ATWATER
Journal: Annals of Internal Medicine (1963)

Article1 March 1963The Latex-fixation Test in Patients with Liver DiseaseEDWARD C. ATWATER, M.D., RALPH F. JACOX, M.D., F.A.C.P.EDWARD C. ATWATER, M.D.Search for more papers by this author, RALPH F. JACOX, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-3-419 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years it has been demonstrated that macroglobulins exist in the sera of most patients with rheumatoid arthritis. One technique for demonstrating this depends on the ability of these macroglobulins to agglutinate 7S gamma globulin. The latex-fixation test is an application of this process. Using this test, several investigators have reported agglutinating factors in the sera of patients with diseases other than rheumatoid arthritis, such as sarcoidosis, syphilis, pulmonary fibrosis, acute viral illnesses, and liver disease (1-9).A study of the latex-fixation reaction in the sera of 165 patients with various disturbances of hepatic function and morphology is presented...References1. TAWILABD EL WAHAB GSEM: Sensitization of sheep erythrocytes by abnormal human serums. Amer. J. Clin. Path. 25: 166, 1955. CrossrefMedlineGoogle Scholar2. ZIFF M: The agglutination reaction in rheumatoid arthritis. J. Chron. Dis. 5: 644, 1957. CrossrefMedlineGoogle Scholar3. KUNKELSIMONFUDENBERG HGHJH: Observations concerning positive serologic reactions for rheumatoid factor in certain patients with sarcoidosis and other hyperglobulinemic states. Arthritis Rheum. 1: 289, 1958. CrossrefMedlineGoogle Scholar4. DRESNERTROMBLY EP: The latex-fixation reaction in nonrheumatic diseases. New Engl. J. Med. 261: 981, 1959. CrossrefMedlineGoogle Scholar5. PELTIERCHRISTIAN ACL: The presence of the 'rheumatoid factor' in sera from patients with syphilis. Arthritis Rheum. 2: 1, 1959. CrossrefMedlineGoogle Scholar6. BLOOMFIELD N: Reactions in the latex-fixation test for rheumatoid arthritis with serum of syphilitic individuals. J. Lab. Clin. Med. 55: 73, 1960. MedlineGoogle Scholar7. COHENSHIMAOKAHERMES EKP: Letter to the editor. Lancet 1: 1352, 1960. CrossrefGoogle Scholar8. HOWELLMALCOLMPIKE DSJMR: The F-II agglutinating factors in serums of patients with non-rheumatic diseases. Amer. J. Med. 29: 662, 1960. CrossrefMedlineGoogle Scholar9. TOMASIFUDENBERGFINBY TBHN: Possible relationship of rheumatoid factors and pulmonary disease. Presented at the annual meeting of the American Rheumatism Association, New York, June 22-23, 1961 (abstracted in Arthritis Rheum. 4: 444, 1961). Google Scholar10. SINGERPLOTZ JMCM: The latex-fixation test. Amer. J. Med. 21: 888, 1956. CrossrefMedlineGoogle Scholar11. SCHUBARTCOHENCALKINS AFASE: Latex-fixative test in rheumatoid arthritis. I. Clinical significance of a thermolabile inhibitor. New Engl. J. Med. 261: 363, 1959. CrossrefGoogle Scholar12. EPSTEINENGLEMANROSS WVEPM: Evaluation of a qualitative precipitation reaction for the detection of the rheumatoid factor. Ann. Rheum. Dis. 16: 448, 1957. CrossrefMedlineGoogle Scholar13. KISSICK WL: Studies of the epidemiology of the rheumatoid factor. Presented at the annual meeting of the American Rheumatism Association, June 22-23, 1961 (abstracted in Arthritis Rheum. 4: 424, 1961). Google Scholar14. HEIMERRUDD RE: Globulins resembling the rheumatoid factors in the sera of the aged. Presented at the Eighth Interim Scientific Session of the American Rheumatism Association, Washington, D. C., December 8-9, 1961 (abstracted in Arthritis Rheum. 5: 110, 1962). Google Scholar15. WILLIAMSKUNKEL RCHG: Rheumatoid factors and their disappearance following therapy in patients with subacute bacterial endocarditis. Ibid. 126. Google Scholar16. ABRUZZOCHRISTIAN JLCL: The induction of a rheumatoid factor-like substance in rabbits. J. Exp. Med. 114: 791, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New YorkFrom the Department of Medicine, University of Rochester School of Medicine and Dentistry, 260 Crittenden Boulevard, Rochester, New York, and the Arthritis Clinical Study Section of Strong Memorial Hospital.This work was supported by a traineeship in arthritis and metabolic disease, National Institutes of Health, United States Public Health Service, grant 2A-5188, and the National Foundation, grant CRMC 24. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAn investigation on rheumatoid factor of different immunoglobulin classes in hepatitis B virus crriersRheumatoid arthritis—A sequel to HBsAg hepatitisMultiple IgM autoantibodies in a non-human primateLiver Disease Due to Infection and AllergyFalse positive latex in a tropical areaImmunpathogenese chronisch-entzündlicher LebererkrankungenCirrhosis of the liver in Iran a prospective study on 66 casesImmunological Tests in Liver DiseasesActive chronic hepatitisSerum Immunoglobulin Concentrations in Patients with Alcoholic Liver DiseaseImmune Reactions in Chronic Liver DiseasesAntibodies and immunoglobulins in liver disease.Intracytoplasmic inclusions of immunoglobulins in rheumatoid arthritis and other diseasesUntersuchungen eines Zusammenhanges zwischen positivem „Rheumafaktor“-Latextropfentest und dem Makroglobulingehalt des Serums bei chronischen LebererkrankungenCOMPLEMENT-FIXING LIVER ANTIBODIES.The distribution of serum immunoglobulins, anti-γ-G globulins (“rheumatoid factors”) and antinuclear antibodies in white and negro subjects in Evans County, GeorgiaVirushepatitisÜber Anti-Gamma-Globulinfaktoren bei LebererkrankungenVirushepatitisAgglutinins eluted from erythrocytes of rheumatoid patientsLatex Slide Test in Thyroid DiseasesA Genetic Approach to the Pathogenesis of Hepatic Cirrhosis A Clinical and Serological StudyTissue-Specific AntigensThe significance of antinuclear factors in rheumatoid arthritisIMMUNOGLOBULINS IN VIRAL HEPATITIS AND ACTIVE ALCOHOLIC LIVER-DISEASETests for rheumatoid factor after myocardial infarctionDie Pathogenese der chronischen Hepatitis als immunologisches ProblemChronic Active ("Lupoid") Hepatitis A Clinical, Serological, and Pathological Study of 20 PatientsMARGARET J. MACLACHLAN, M.D., GERALD P. RODNAN, M.D., F.A.C.P., WILLIAM M. COOPER, M.D., F.A.C.P., R. H. FENNELL JR., M.D.Systemic lupus erythematosusThe Use of Latex Fixation Tests in Non-rheumatic StatesHUBERT I. CAPLAN, M.D. 1 March 1963Volume 58, Issue 3Page: 419-425KeywordsArthritisEndocarditisHepatitis E virusHospital medicineLatexLiver diseasesRheumatoid arthritisSarcoidosisSyphilisViral diseases Issue Published: 1 March 1963 PDF DownloadLoading ...