Cryoprecipitate Transfusion in Variant von Willebrand's Disease and Thrombocytopenia
Authors: DENNIS M. KRIZEK
Journal: Annals of Internal Medicine (1983)

Brief Reports1 April 1983Cryoprecipitate Transfusion in Variant von Willebrand's Disease and ThrombocytopeniaDENNIS M. KRIZEK, B.S., MARGARET E. RICK, M.D., SYBIL B. WILLIAMS, B.A., HARVEY R. GRALNICK, M.D.DENNIS M. KRIZEK, B.S.Search for more papers by this author, MARGARET E. RICK, M.D.Search for more papers by this author, SYBIL B. WILLIAMS, B.A.Search for more papers by this author, HARVEY R. GRALNICK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-4-484 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVon Willebrand's disease is a congenital bleeding disorder characterized by mild to severe bleeding, quantitative or qualitative factor VIII molecular defects, and a prolonged bleeding time (1). Type I disease is characterized by a quantitative reduction of factor VIII procoagulant activity, von Willebrand factor activity, and factor-VIII-related antigen. Although lower in quantity than normal, the factor-VIII-related antigen of type I von Willebrand's disease contains the full range of factor-VIII-related antigen multimers (0.8 X 106to approximately 20 X 106daltons) when assessed by sodium dodecyl sulfate agarose gel electrophoresis. Type II von Willebrand's disease is characterized by variable plasma levels...References1. HOYER L. The factor VIII complex: structure and function. Blood. 1981;58:1-13. CrossrefMedlineGoogle Scholar2. RUGGERIPARETIMANNUCCICIAVARELLAZIMMERMAN ZFPNT. Heightened interaction between platelets and factor VIII/von Willebrand factor in a new subtype of von Willebrand's disease. N Engl J Med. 1980;302:1047-51. CrossrefMedlineGoogle Scholar3. TAKAHASHI H. Studies on the pathophysiology and treatment of von Willebrand's disease: IV. Mechanism of increased ristocetin-induced platelet aggregation in von Willebrand's disease. Thromb Res. 1980;19:857-67. CrossrefMedlineGoogle Scholar4. GRALNICKWILLIAMSSHAFERCORASH HSBL. Factor VIII/von Willebrand factor binding to von Willebrand's disease platelets. Blood. 1982;60:328-32. CrossrefMedlineGoogle Scholar5. GRALNICKCREGGERWILLIAMS HMS. Characterization of the defect of the factor VIII/von Willebrand factor protein in von Willebrand's disease. Blood. 1982;59:542-8. CrossrefMedlineGoogle Scholar6. WEINGERCIMOMOAKEOLSONHELLER RPJJM. Type IIB von Willebrand's disease: unusual response to cryoprecipitate infusion. Ann Intern Med. 1981;94:47-50. LinkGoogle Scholar7. WEISSMEYERRABINOWITZ HDR. Pseudo-von Willebrand's disease: an intrinsic defect with aggregation by unmodified human factor VIII/von Willebrand factor and enhanced adsorption of its high-molecular weight multimers. N Engl J Med. 1982;306:326-33. CrossrefMedlineGoogle Scholar8. MIELKEKANESHIROMAHERWEINERRAPAPORT CMIJS. The standardized normal Ivy bleeding time and its prolongation by aspirin. Blood. 1969;34:204-15. CrossrefMedlineGoogle Scholar9. GRALNICKCOLLERSULTAN HBY. Studies of the human factor VIII/von Willebrand factor protein: III. Qualitative defects in von Willebrand's disease. J Clin Invest. 1975;56:814-27. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hematology Service National Institutes of Health Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDiagnosis and treatment of von Willebrand's diseaseA modified SDS agarose gel method for determining Factor VIII von Willebrand Factor multimers using commercially available reagentsDas v. Willebrand-Jürgens-SyndromMolecular Defects in Interactions of Platelets with the Vessel Wall 1 April 1983Volume 98, Issue 4Page: 484-486KeywordsAntigensBlood plasmaGel electrophoresisHematology and oncologyHemorrhageSodiumSulfatesvon Willebrand disease Issue Published: 1 April 1983 PDF DownloadLoading ...