The Physiologic Basis for Therapy of Classic Hemophilia (Factor VIII Deficiency) and Related Disorders
Authors: N. RAPHAEL SHULMAN
Journal: Annals of Internal Medicine (1967)

Clinical Staff Conference1 October 1967The Physiologic Basis for Therapy of Classic Hemophilia (Factor VIII Deficiency) and Related DisordersCombined Clinical Staff Conference at the National Institutes of HealthN. RAPHAEL SHULMAN, M.D., DALE H. COWAN, M.D., EUGENE P. LIBRE, M.D., STANLEY P. WATKINS JR., M.D., VICTOR J. MARDER, M.D.N. RAPHAEL SHULMAN, M.D.Search for more papers by this author, DALE H. COWAN, M.D.Search for more papers by this author, EUGENE P. LIBRE, M.D.Search for more papers by this author, STANLEY P. WATKINS JR., M.D.Search for more papers by this author, VICTOR J. MARDER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-4-856 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. N. Raphael Shulman: In the past few years much new information has been acquired concerning the pathophysiology and therapy of classic hemophilia and other diseases involving factor VIII deficiency. Most important has been a revolution in treatment permitted by the availability of factor VIII concentrates. Hemostasis in hemophiliacs, which several years ago presented a difficult if not hopeless problem, now can be managed with complete effectiveness in a rather routine manner. In addition, there is a clearer concept of the genetic control of factor VIII, provided chiefly by studies of von Willebrand's disease; and recently, there have been some...References1. DAVIERATNOFF EWOD: Waterfall sequence for intrinsic blood clotting. Science 145: 1310, 1964. CrossrefMedlineGoogle Scholar2. MACFARLANE RG: An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier. Nature (London) 202: 498, 1964. CrossrefMedlineGoogle Scholar3. 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Department of Health, Education, and Welfare.Requests for reprints should be addressed to N. Raphael Shulman, M.D., Chief, Clinical Hematology Branch, National Institute of Arthritis and Metabolic Diseases, Bldg. 10, Room 9N250, National Institutes of Health, Bethesda, Md. 20014. 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RAPHAEL SHULMAN, M.D. 1 October 1967Volume 67, Issue 4Page: 856-882KeywordsArthritisGenetic diseasesHemophilia AHemostasisMedical servicesMetabolic disordersPrevention, policy, and public healthvon Willebrand disease Issue Published: 1 October 1967 PDF DownloadLoading ...