tbuckley/cabot-search huggingface dataset:
THE NEW YORK STATE COMMUNITY MENTAL HEALTH SERVICES ACT: ITS BIRTH AND EARLY DEVELOPMENT
Authors: ROBERT C. HUNT, HYMAN M. FORSTENZER
Journal: American Journal of Psychiatry (1957)

We have described the origins, principles, and provisions of an attempt to establish a comprehensive community mental health program for an entire state. Widespread citizen readiness for coordinated and integrated planning of mental health services has been demonstrated, as has local and state government willingness to finance large-scale programs. This has focussed attention on the need for developing methods of evaluating the effectiveness of services and for more research especially into the causes of mental illness. The need for training of professional personnel is stressed; the demand greatly exceeds supply, and teaching centers give little training in community oriented psychiatry.
Is it permissible to edit medical records?
Authors: B J Kirby
Journal: BMJ (1991)

sought to raise theoretical and political questions about the nature of public health in the nineteenth century.It ends by saying: ... we cannot afford to romanticise the public health movement of the nineteenth century.It achieved certain notable successes, though these were fre- quently based more upon ideology than science.But, more importantly, its ideological impulses were often subservient to narrow class interests.One of the people to whom I think this particularly applies is Edwin Chadwick, whose heroic role in the mythology of public health in England Dr Ashton implicitly endorsed in an editorial.2This suggests that when Dr Ashton describes my chapter as idiosyncratic he is simply misleading the reader.
Metronidazole in prevention and treatment of bacteroides infections in elective colonic surgery.
Authors: A T Willis, I R Ferguson, P H Jones, K D Phillips, P V Tearle, R V Fiddian, D F Graham, D H Harland, D F Hughes, D Knight, W M Mee, N Pashby, R L Rothwell-Jackson, A K Sachdeva, I Sutch, C Kilbey, D Edwards
Journal: BMJ (1977)

A double-blind randomised trial was carried out among 46 patients undergoing elective colonic surgery; 27 patients received prophylactic metronidazole and 19 received placebo. Anaerobic infections did not develop in any of the metronidazole-treated patients, but did develop in 11 (58%) of 19 controls who were subsequently successfully treated with metronidazole.
Hemoglobin miyada: DNA analysis of the anti-lepore βδ fusion gene
Authors: M. Catherine Driscoll, Yoshiro Ohta, Frank Nakamura, Arthur Bloom, Arthur Bank
Journal: American Journal of Hematology (1984)

Abstract Hemoglobin Miyada, an anti‐Lepore hemoglobin, represents the protein product of a nonhomologous crossover between β and δ genes. The mutant globin is β‐like from the N terminus to amino acid 12, and δ‐like from amino acid 22 through the C terminus, thus predicting a crossover site in the first coding region of the gene. DNA analysis, using multiple restriction endonucleases and hybridization to δ and β globin gene‐specific probes, confirms that the βδ hybrid gene 1) is located on a single chromosomal fragment between normal δ and β genes, and 2) has 5′ β promoter sequences, δ IVS 1 and 2, and 3′ coding and flanking sequences.
Health of the Nation
Authors: A. Daley
Journal: BMJ (1951)

An occasion such as this gives an opportunity to take stock of the national health-a subject which con- cerns all of us.We are perhaps too much inclined as a profession to limit our vision to our success, or other- wise, in the treatment of the individual sick person who seeks our aid, and to forget that the function of doctors as a profession is to preserve health, to try to get our patients to come to us at the beginnings of disease and not to wait until irreparable dam- METROPOLIS
THE PSYCHOLOGY AND PHYSIOLOGY OF THE LAYING ON OF HANDS AND OF HYPNOTISM.
Authors: RANDELL HUNT
Journal: JAMA (1898)

"The smallest hurts sometime increase and rage More than all art of physic can assuage; Sometimes the fury of the worst disease The hand, by gentle stroking will appease."—<i>Solon.</i> Socratic reasoning is being revived, and in the garb of Baconian induction is demonstrating particular truths and predicating general principles that astound even the learned, relegating to their proper place among the relics of barbaric times, intolerance, foolish ridicule, and impotent invective. No longer is the medical profession ready and eager to deride and martyrize a Harvey and a Jenner, nor a French Academy of Science to deny the actuality of meteorites; for science and wisdom walk hand in hand, giving to the world knowledge of universal truths, and power to observe and practice them. Before man is in a position to take advantage of all these psychic facts that science is in some sort freeing from the mystery that
THE TREATMENT OF RODENT ULCERS BY CURETTAGE AND CAUTERIZATION.*
Authors: J. R. SIMPSON
Journal: British Journal of Dermatology (1966)

Journal Article THE TREATMENT OF RODENT ULCERS BY CURETTAGE AND CAUTERIZATION. Get access J. R. SIMPSON J. R. SIMPSON Royal Devon and Exeter Hospital, Exeter Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 78, Issue 3, 1 March 1966, Pages 147–148, https://doi.org/10.1111/j.1365-2133.1966.tb12191.x Published: 01 March 1966
CHOP plus Rituximab — Balancing Facts and Opinion
Authors: Bruce D. Cheson
Journal: New England Journal of Medicine (2002)

Research on the treatment of the non-Hodgkin's lymphomas has finally emerged from decades of stagnation. These lymphomas, which usually arise from B lymphocytes, are the fifth most common type of cancer in the United States and are the fifth and sixth leading cause of death from cancer in men and women, respectively.1 Approximately 25 to 30 percent of non-Hodgkin's lymphomas have an indolent course; the remainder are aggressive tumors. For 25 years, the standard treatment for diffuse large-B-cell lymphoma, the most common of the aggressive non-Hodgkin's lymphomas, has been a regimen of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), which cures . . .
Traumatic neuropathy of second cervical spinal nerves.
Authors: S Behrman
Journal: BMJ (1983)

The second cervical spinal nerves are unduly vulnerable to forcible approximation of the arches of the atlas and axis and to excessive rotation of the atlas on the axis. Sequelae of such injury include sensory aberrations ranging from loss of feeling to severe neuralgia and disorders of balance. Diagnosis of second cervical neuropathy may be difficult when there are multiple injuries to the cervical spine, but most cases clear up spontaneously within one to three years.
The Role of Peritoneoscopy in the Diagnosis of Intra-abdominal Disease.
Authors: Norman M. Scott
Journal: Annals of Internal Medicine (1966)

s1 May 1966The Role of Peritoneoscopy in the Diagnosis of Intra-abdominal Disease.Norman M. Scott Jr., Anton L. Hitzelberger, Gerald W. ParkerNorman M. Scott Jr.Search for more papers by this author, Anton L. HitzelbergerSearch for more papers by this author, Gerald W. ParkerSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1162_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPeritoneoscopy or laparoscopy as it is known in European countries has been performed with increasing enthusiasm for a half century, and many publications—particularly in the past 15 to 20 years—have demonstrated the value of the procedure. Yet today there are many centers that are not taking advantage of this diagnostic tool. Modern technical improvements permit not only tissue diagnoses and more productive procedures, but invaluable documentation of disease states by means of still and motion photography.Peritoneoscopy frequently makes laparotomy unnecessary. Occasionally, unexpected findings during peritoneoscopy may provide a definite indication for exploration. This information is gained at the small... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Norman M. ScottJr.; Anton L. Hitzelberger; Gerald W. Parker PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1162-1162KeywordsLaparoscopyLaparotomyPhotography ePublished: 1 December 2008 Issue Published: 1 May 1966 PDF downloadLoading ...
Isradipine in Prediabetic Hypertensive Subjects
Authors: Robert P Byington, Curt D Furberg, Timothy E Craven, Marco Pahor, James R Sowers
Journal: Diabetes Care (1998)

OBJECTIVE Investigators from the Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS) previously reported that the isradipine group had a higher incidence of cardiovascular disease (CVD) events than the diuretic group. The ultimate objective of the analyses presented here was to assess how indices of glycemia (specifically, serum glucose, serum insulin, and HbAlc)might have influenced the effects of the two agents on blood pressure control and CVD events. RESEARCH DESIGN AND METHODS Inclusion criteria included men and women ≥40 years of age with ultrasonographically confirmed carotid atherosclerosis and a diastolic blood pressure of &amp;gt;90 mmHg. Although insulin-dependent diabetic patients were excluded, the three glycemia indices had wide enough ranges to include patients who may be classified as prediabetic. A total of 883 patients were randomized either to the dihydropyridine calcium antagonist (CA) isradipine (2.5–5 mg twice a day) or to the diuretic hydrochlorothiazide (12.5–25 mg twice a day) and followed in double-blind fashion for 3 years. RESULTS Both treatment groups had achieved comparable control of diastolic blood pressure, and there were no statistically significant differences in any of the glycemia indices, either at baseline or during follow-up. However, the excess isradipine events were noted to be clustered among those patients with elevated baseline levels of HbA1c who also experienced greater blood pressure reductions during follow-up. CONCLUSIONS The increased cardiovascular risk associated with dihydropyridine CAs in prediabetic patients may be an explanation for the overall CA debate.
Early-Life Exposure to Outdoor Air Pollution and Respiratory Health, Ear Infections, and Eczema in Infants from the INMA Study
Authors: Inmaculada Aguilera, Marie Pedersen, Raquel Garcia-Esteban, Ferran Ballester, Mikel Basterrechea, Ana Esplugues, Ana Fernández-Somoano, Aitana Lertxundi, Adonina Tardón, Jordi Sunyer
Journal: Environmental Health Perspectives (2012)

Prenatal and early-life periods may be critical windows for harmful effects of air pollution on infant health.We studied the association of air pollution exposure during pregnancy and the first year of life with respiratory illnesses, ear infections, and eczema during the first 12-18 months of age in a Spanish birth cohort of 2,199 infants.We obtained parentally reported information on doctor-diagnosed lower respiratory tract infections (LRTI) and parental reports of wheezing, eczema, and ear infections. We estimated individual exposures to nitrogen dioxide (NO(2)) and benzene with temporally adjusted land use regression models. We used log-binomial regression models and a combined random-effects meta-analysis to estimate the effects of air pollution exposure on health outcomes across the four study locations.A 10-µg/m(3) increase in average NO(2) during pregnancy was associated with LRTI [relative risk (RR) = 1.05; 95% CI: 0.98, 1.12] and ear infections (RR = 1.18; 95% CI: 0.98, 1.41). The RRs for an interquartile range (IQR) increase in NO(2) were 1.08 (95% CI: 0.97, 1.21) for LRTI and 1.31 (95% CI: 0.97, 1.76) for ear infections. Compared with NO(2), the association for an IQR increase in average benzene exposure was similar for LRTI (RR = 1.06; 95% CI: 0.94, 1.19) and slightly lower for ear infections (RR = 1.17; 95% CI: 0.93, 1.46). Associations were slightly stronger among infants whose mothers spent more time at home during pregnancy. Air pollution exposure during the first year was highly correlated with prenatal exposure, so we were unable to discern the relative importance of each exposure period.Our findings support the hypothesis that early-life exposure to ambient air pollution may increase the risk of upper and lower respiratory tract infections in infants.
Effects of Oral Steroids on Blood CXCR3+ and CCR4 + T Cells in Patients with Bronchial Asthma
Authors: KAZUYOSHI KURASHIMA, MASAKI FUJIMURA, SHIGEHARU MYOU, KAZUO KASAHARA, HIDEKI TACHIBANA, NORINAO AMEMIYA, YOSHIHISA ISHIURA, NOBUYUKI ONAI, KOUJI MATSUSHIMA, SHINJI NAKAO
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Corticosteroids are widely used in bronchial asthma, but their mechanism of action is not fully understood. The in vitro studies have proposed that human T helper cells, type 1 (Th1) favor expression of CXCR3, whereas Th2 cells favor CCR4. In this study we investigated whether oral prednisolone modulates the balance of peripheral blood CXCR3+ and CCR4+ T cells. We analyzed the T-cell subsets in 28 patients with stable atopic asthma and 13 normal control subjects before and after 2 wk of treatment with prednisolone, 20 mg/d, or placebo in a randomized, double-blind, parallel group study. The numbers of CXCR3+ and CCR4+ memory T cells were measured with a flow cytometer, and expressed as percentages in CD4+/CD45RO+ memory T cells. In the steroid-treated asthma group, there was a decrease in CCR4+ T cells (from 29.3% to 20.3%, p < 0.0001), and an increase in CXCR3+/ CCR4+ ratio (from 1.86 to 2.89, p = 0.0047), whereas there was no change in CXCR3+ T cells. However, the percentages of CCR4+ cells did not change after steroid therapy in normal control subjects. These results suggest that short-term oral corticosteroid modulates the balances of CXCR3+ and CCR4+ cells in patients with asthma.
Vaccination with Recombinant Aspartic Hemoglobinase Reduces Parasite Load and Blood Loss after Hookworm Infection in Dogs
Authors: Alex Loukas, Jeffrey M Bethony, Susana Mendez, Ricardo T Fujiwara, Gaddam Narsa Goud, Najju Ranjit, Bin Zhan, Karen Jones, Maria Elena Bottazzi, Peter J Hotez
Journal: PLoS Medicine (2005)

Background Hookworms infect 730 million people in developing countries where they are a leading cause of intestinal blood loss and iron-deficiency anemia. At the site of attachment to the host, adult hookworms ingest blood and lyse the erythrocytes to release hemoglobin. The parasites subsequently digest hemoglobin in their intestines using a cascade of proteolysis that begins with the Ancylostoma caninum aspartic protease 1, APR-1. Methods and Findings We show that vaccination of dogs with recombinant Ac-APR-1 induced antibody and cellular responses and resulted in significantly reduced hookworm burdens (p = 0.056) and fecal egg counts (p = 0.018) in vaccinated dogs compared to control dogs after challenge with infective larvae of A. caninum. Most importantly, vaccinated dogs were protected against blood loss (p = 0.049) and most did not develop anemia, the major pathologic sequela of hookworm disease. IgG from vaccinated animals decreased the catalytic activity of the recombinant enzyme in vitro and the antibody bound in situ to the intestines of worms recovered from vaccinated dogs, implying that the vaccine interferes with the parasite's ability to digest blood. Conclusion To the best of our knowledge, this is the first report of a recombinant vaccine from a hematophagous parasite that significantly reduces both parasite load and blood loss, and it supports the development of APR-1 as a human hookworm vaccine.
Hub GABA Neurons Mediate Gamma-Frequency Oscillations at Ictal-like Event Onset in the Immature Hippocampus
Authors: Pascale P. Quilichini, Michel Le Van Quyen, Anton Ivanov, Dennis A. Turner, Aurélie Carabalona, Henri Gozlan, Monique Esclapez, Christophe Bernard
Journal: Neuron (2012)
Effects of Fish Oil Supplements in NIDDM Subjects: Controlled Study
Authors: Timothy J Hendra, Mary E Britton, David R Roper, Daniel Wagaine-Twabwe, James Y Jeremy, Paresh Dandona, Andrew P Haines, John S Yudkin
Journal: Diabetes Care (1990)

The aim of this study was to evaluate the effects of a fish oil preparation (MaxEPA) on hemostatic function and fasting lipid and glucose levels in non-insulin-dependent diabetic (NIDDM) subjects. Eighty NIDDM outpatients aged 55.9 yr (mean SD 11.5 yr) participated in a prospective double-blind placebo-controlled study of MaxEPA capsules (10 g/day) or olive oil (control) treatment over 6 wk. Patients received either MaxEPA or olive oil in addition to preexisting therapy. Metabolic and hemostatic variables were measured before treatment and after 3 and 6 wk. Platelet membrane eicosapentaenoic acid (EPA) content increased in the treatment group (P &amp;lt; 0.001). MaxEPA supplementation was associated with a significant fall in total triglycerides (P &amp;lt; 0.001) but did not affect total cholesterol (P = 0.7) compared with control treatment. Fasting plasma glucose increased after 3 wk (P = 0.01) but not after 6 wk (P = 0.17) treatment with MaxEPA. Spontaneous platelet aggregation in whole blood fell in the MaxEPA group (P &amp;lt; 0.02) after 6 wk, but there were no changes in agonist-induced platelet aggregation, thromboxane generation in platelet-rich plasma, or plasma P-thromboglobulin and platelet factor IV levels. An increase in clotting factor VII (P = 0.02), without changes in fibrinogen or factor X levels, occurred in the MaxEPA group. Similar reductions in blood pressure were observed in both groups. Dietary supplementation with MaxEPA capsules (10 g/day) in NIDDM subjects is associated with improvement in hypertriglyceridemia but with deleterious effects in factor VII and blood glucose levels. Most indices of platelet function are unaffected by this therapy.
PHARMACODYNAMICS OF VORAPAXAR, A PLATELET PAR-1 ANTAGONIST, AND ITS INTERACTION WITH P2Y12 RECEPTOR PATHWAY IN THE TRACER TRIAL
Authors: Lisa K. Jennings, David Moliterno, Robert Storey, Edward Hord, Jayaprakash Kotha, Richard Becker, Susan Smyth, Luis Providencia, Tiziano Moccetti, Marco Valgimigli, Jean-Pierre Dery, J.H. Cornel, Gregory Thomas, Kurt Huber, Edmond Chen, John Strony, Tyrus Rorick, Pierluigi Tricoci, Kenneth Mahaffey
Journal: Journal of the American College of Cardiology (2012)
The Effects of Psychotherapy
Authors: Norman R. Bernstein
Journal: JAMA (1980)

Michael J. Lambert of the Institute for Studies in Values and Human Behavior, Department of Psychology, Brigham Young University, wrote this review of studies on the results of psychological treatment. This is a first volume in a series put out by<i>Annual Research Reviews</i>published by Eden Press. The work surveys the effectiveness of psychotherapy and the research methods for studying this. It skillfully clarifies many of the professional controversies and concludes that there is a definite, but modest, positive result from therapy when compared with no treatment, waiting lists, and placebos. There is a brief, incompletely explained summary of the deterioration in patients, which may be caused by therapy itself. The volume attempts to look primarily at individual psychotherapy, but it includes some material on group treatment, behavior therapy, and family therapy and covers nonmedical as well as medical therapists. (Reference is made throughout to clients rather than to
Intravenous coronary angiography by use of dichromography with synchrotron radiation
Authors: Christian W. Hamm, Wolf-Rainer Dix, Clemens Rust, Walter Graeff, Gerd Illing, Michael Lohmann, Ralf Menk, Bernd Reime, Lothar Schildwächter, Hans Besch, Albert Walenta, Thomas Meinertz, Wolfram Kupper
Journal: Journal of the American College of Cardiology (1996)
Disease-Specific Health Status After Stent-Assisted Percutaneous Coronary Intervention and Coronary Artery Bypass Surgery
Authors: Zefeng Zhang, Elizabeth M. Mahoney, Rodney H. Stables, Jean Booth, Fiona Nugara, John A. Spertus, William S. Weintraub
Journal: Circulation (2003)

Background— Functional status and quality of life are important outcomes in the evaluation of revascularization approaches for symptomatic coronary artery disease. Few data are available regarding the comparative improvement in disease-specific health status after CABG versus percutaneous coronary intervention (PCI) in the era of coronary stenting. Methods and Results— Cardiac-specific health status was evaluated at baseline and at 6 and 12 months after intervention with the Seattle Angina Questionnaire (SAQ) in patients randomized to stent-assisted PCI (n=488) versus CABG (n=500) in the Stent or Surgery trial. Scores for physical limitation, angina frequency, and quality of life improved significantly for both treatment groups at 6 months (range of improvement from 13.6 to 34.7 points) and 12 months (14.3 to 38.2 points; all P &lt;0.001). CABG patients had greater improvement than those assigned to PCI, although the magnitude of the difference decreased over time (difference at 6 months, 4.03 to 6.48 points; 12 months, 2.05 to 2.93 points). A component of this reduction is accounted for by PCI-arm patients who required repeat intervention. Differences between treatment groups were greatest for the 6-month angina frequency scores (difference=6.48 points; 95% CI 3.96 to 8.99). Overall, treatment satisfaction was high and did not differ significantly between groups. Conclusions— Both CABG and stent-assisted PCI dramatically improved cardiac-related health status in patients with multivessel disease at 6- and 12-month follow-up. During the first postprocedure year, patients’ angina burden and physical limitations were alleviated to a greater extent with CABG.
FDG Accumulation in Obturator Herniation of the Bladder Mimicking Metastatic Disease
Authors: Tomohiro Kaneta, Kentaro Takanami, Atsushi Mitamura, Tomomichi Hiraide, Hiroshi Fukuda, Shogo Yamada, Shoki Takahashi
Journal: Clinical Nuclear Medicine (2009)

FDG PET was performed on a 73-year-old woman as a follow-up examination after chemoradiotherapy for esophageal cancer. Increased uptake was noted in the left inguinal region, suggesting a metastatic lymph node. PET/CT revealed that the precise location of the hot spot was in the left obturator foramen. Previous FDG PET had shown the continuity of the bladder uptake to the left obturator foramen, suggesting obturator herniation of the bladder.
Deadline approaches to claim funding in England for continuing healthcare needs
Authors: M. Limb
Journal: BMJ (2012)

Doctors and legal experts are urging the families of patients who have continuing healthcare needs to be aware that time is running out to claim funding for care fees from primary care trusts in England.

People must apply before 30 September this year if they believe that they should have been assessed as eligible for continuing healthcare funding between1 April 2004 and 31 March 2011.

NHS continuing healthcare payments are defined as a package of care arranged and funded solely by the NHS to meet physical or mental health needs (or both) that result from disability, accident, or illness. They can meet the care costs of people living at home or in care homes, such as someone needing rehabilitation after a stroke or spinal injury. …
IN VIVO MORPHOLOGIC ANALYSIS OF PLAQUE RUPTURE IN CULPRIT LESIONS OF PATIENTS WITH ACUTE CORONARY SYNDROMES. AN OPTICAL COHERENCE TOMOGRAPHY STUDY
Authors: Antonios Karanasos, Konstantinos Toutouzas, Andreas Synetos, Elefterios Tsiamis, Maria Drakopoulou, John Karambelas, Costas Tsioufis, Dimitrios Tousoulis, Elli Stefanadi, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2010)