Serum Thrombocytopenia and High-Dose Immunoglobulin Treatment
Authors: J. ORDI
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 February 1986Serum Thrombocytopenia and High-Dose Immunoglobulin TreatmentJ. ORDI, M.D., M. VILARDELL, M.D., J. ALIJOTAS, M.D., J. BARQUINERO, M.D., M. VILA, M.D.J. ORDI, M.D.Search for more papers by this author, M. VILARDELL, M.D.Search for more papers by this author, J. ALIJOTAS, M.D.Search for more papers by this author, J. BARQUINERO, M.D.Search for more papers by this author, M. VILA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-2-282_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Thrombocytopenia is a frequent complication in patients with the acquired immunodeficiency syndrome (AIDS). Its cause is poorly understood and has been attributed to several factors (1), mainly circulating immune complexes or antiplatelet IgG antibodies (2). We report the case of a hemophilic patient with AIDS who had severe autoimmune thrombocytopenia that responded to treatment with high doses of intravenous immunoglobulin.A 32-year-old man with severe hemophilia A (factor VIII: C > 1%) had been treated with factor VIII concentrates during the past 10 years. In September 1984 he began to notice asthenia, anorexia, weight loss (10 kg),...References1. SPIVAK J, BENDER B, and QUINN T. Hematologic abnormalities in the acquired immunodeficiency syndrome. Am J Med 1984;77:224-8. CrossrefMedlineGoogle Scholar2. WALSH C, NARDI M, and KARPATKIN S. On the mechanism of the thrombocytopenic purpura in sexually active homosexual men. N Engl J Med. 1983;311:635-9. CrossrefGoogle Scholar3. RATNOFF O, MENITOVE J, ASTER R, and LEDERMANI M. Coincident classic hemophilia and idiopathic thrombocytopenic purpura in patients under treatment with concentrates of antihemophilic factor (factor VIII). N Engl J Med. 1983;308:439-42. CrossrefMedlineGoogle Scholar4. IMBACH P, D'APUZZO V, and HIRT A. High-dose intravenous gammaglobulin for idiopathic thrombocytopenic purpura in childhood. Lancet. 1981;1:1228-31. CrossrefMedlineGoogle Scholar5. FEHR J, HOFMANN V, and KAPPLER U. Transient reversal of thrombocytopenia in idiopathic thrombocytopenic purpura by high-dose intravenous gammaglobulin. N Engl J Med. 1982;306:1254-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. ORDI, M.D.; M. VILARDELL, M.D.; J. ALIJOTAS, M.D.; J. BARQUINERO, M.D.; M. VILA, M.D.Affiliations: Valle Hebron General Hospital Barcelona Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUsefulness of a low‐dose intravenous immunoglobulin regimen for the treatment of thrombocytopenia associated with AIDSUse of Intravenous Gammaglobulin as an Immune Replacement and an Immune SuppressantHuman immunodeficiency virus-associated autoimmune thrombocytopenic purpura: A reviewAnti-corticosteroid antibodies in AIDS patientsImmunthrombozytopenie bei HIV-Infektion und Hämophilie AThrombozytopenie bei HIV-1-InfektionenIntravenous Immunoglobulins as Therapeutic AgentsE. RICHARD STIEHM, M.D., ELLYN ASHIDA, M.D., KWANG SIK KIM, M.D., DREW J. WINSTON, M.D., ALBERT HAAS, M.D., ROBERT P. GALE, M.D., Ph.D.Response to therapy in 37 patients with HIV-related thrombocytopenic purpuraWorkshop on Immunoglobulin Therapy of Lymphoproliferative Syndromes, Mainly AIDS-Related Complex, and AIDS 1 February 1986Volume 104, Issue 2 Page: 282-283 Keywords AIDS Antibodies Hemophilia A Idiopathic thrombocytopenic purpura Immune complex Intravenous immunoglobulin Weight loss ePublished: 1 December 2008 Issue Published: 1 February 1986 PDF downloadLoading ...