tbuckley/cabot-search huggingface dataset:
Economic Sanctions and Embargoes
Authors: Michèle Barry
Journal: Annals of Internal Medicine (2000)

Letters15 August 2000Economic Sanctions and EmbargoesMichèle Barry, MDMichèle Barry, MDYale School of Medicine; New Haven, CT 06520-8025 (Barry)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-4-200008150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I appreciate the courage of Annals in devoting attention to the morally complex subject of embargoes and how they may affect health (1-3). I humbly take issue with Secretary of State Madeleine Albright's position that the U.S. embargo has permitted generous donations of medical sales and medical equipment to Cuba.Ms. Albright carefully uses the word “licensed” with regard to “$45 million in medical sales in 1998 and the first half of 1999 and more than $100 million in humanitarian donations” (2). In actuality, licenses do not equate to material sent to or received by Cuba. The ...References1. Morin K, Miles SH. The health effects of economic sanctions and embargoes: the role of health professionals. Ethics and Human Rights Committee. Ann Intern Med. 2000;132:158-61. LinkGoogle Scholar2. Albright MK. Economic sanctions and public health: a view from the Department of State [Editorial]. Ann Intern Med. 2000;132:155-7. LinkGoogle Scholar3. Barry M. Effect of the U.S. embargo and economic decline on health in Cuba. Ann Intern Med. 2000;132:151-4. LinkGoogle Scholar4. Denial of Food and Medicine. The Impact of the U.S. Embargo on Health and Nutrition in Cuba. Washington, DC: American Association of World Health; 1997. Google Scholar5. Fletcher P. US health care firms probe tricky Cuban market. 25 January 2000. www.cubanet.org/CNews/y00/jan00/26e11.htm. Last accessed 17 July 2000. Google Scholar Author, Article, and Disclosure InformationAuthors: Michèle Barry, MDAffiliations: Yale School of Medicine; New Haven, CT 06520-8025 (Barry) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Health Effects of Economic Sanctions and Embargoes: The Role of Health Professionals Karine Morin , Steven H. Miles , and Economic Sanctions and Embargoes Michael Brumage Economic Sanctions and Embargoes Ken Freeland Economic Sanctions and Embargoes David P. Hickey Economic Sanctions and Embargoes Leila Richards Economic Sanctions and Embargoes Soheir A. Morsy Economic Sanctions and Embargoes Anthony F. Kirkpatrick Economic Sanctions and Embargoes Richard Garfield Economic Sanctions and Embargoes Natalia Ganson-Myshkin Metrics 15 August 2000Volume 133, Issue 4Page: 311-312KeywordsFoodHealth economics ePublished: 15 August 2000 Issue Published: 15 August 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
SEX-RELATED EFFECTIVENESS OF BIVALIRUDIN VERSUS ABCIXIMAB AND HEPARIN IN NSTEMI: LESSONS FROM THE INTRACORONARY STENTING AND ANTITHROMBOTIC REGIME: RAPID EARLY ACTION FOR CORONARY TREATMENT (ISAR-REACT-4) TRIAL
Authors: David Jochheim, FJ Neumann, Gjin Ndrepepa, lamin king, Stefanie Schulz, Joerg Hausleiter, Jurgen Pache, Ilka Ott, Robert Byrne, Steffen Massberg, Adnan Kastrati, Julinda Mehilli
Journal: Journal of the American College of Cardiology (2013)
Diagnosis of Pancreatic Carcinoma by Photoscanning
Authors: John A. Burdine
Journal: JAMA (1965)

Pancreas scintiscanning with selenomethionine Se 75 and the photoscanner was employed in the study of 29 patients suspected of having pancreatic disease. In six of these patients, abnormalities ranging from localized defects to nonvisualization were encountered and subsequently proved to be caused by pancreatic adenocarcinoma. In four of these six cases, the pancreas scan was the only diagnostic test clearly implicating the pancreas as the source of difficulty. Due to the somewhat limited experience with this technique, pancreas scanning would be performed and the scintiscans interpreted with caution. These cases do demonstrate that the procedure can be a useful adjunct in the diagnosis of pancreatic carcinoma.
Increased lung vasoreactivity in children from Leadville, Colorado, after recovery from high-altitude pulmonary edema.
Authors: J W Fasules, J W Wiggins, R R Wolfe
Journal: Circulation (1985)

Cardiac catheterization was performed on seven children after recovery from high-altitude pulmonary edema. All were life-long residents at elevations above 10,000 feet. Three of the seven had developed pulmonary edema without antecedent travel to low altitude but had an upper respiratory infection. Response of pulmonary arterial pressure to 16% inspired oxygen in all seven was compared with that in six well children who resided at a similar altitude and had no history of high-altitude pulmonary edema. With hypoxia the susceptible patients had a greater mean pulmonary arterial pressure (56.3 +/- 23.8) than the nonsusceptible children (18.8 +/- 3.9, p less than .05). Comparison with historical hemodynamic responses in children at high altitudes showed a similar greater mean pulmonary arterial pressure in the susceptible children. Thus, in children from high altitudes, increased pulmonary vasoreactivity to hypoxia may play a role in the pathogenesis of high-altitude pulmonary edema. The development of pulmonary edema in high-altitude residents with upper respiratory infections and no antecedent low-altitude journey is consistent with the presence of other factors such as inflammation, which may play a role in the pathogenesis of the edema. The finding of right ventricular hypertrophy on an electrocardiogram in children from high altitudes may be predictive of their susceptibility to high-altitude pulmonary edema.
In Vivo Gene Delivery by Nonviral Vectors: Overcoming Hurdles?
Authors: Yuan Zhang, Andrew Satterlee, Leaf Huang
Journal: Molecular Therapy (2012)

The promise of cancer gene therapeutics is hampered by difficulties in the in vivo delivery to the targeted tumor cells, and systemic delivery remains to be the biggest challenge to be overcome. Here, we concentrate on systemic in vivo gene delivery for cancer therapy using nonviral vectors. In this review, we summarize the existing delivery barriers together with the requirements and strategies to overcome these problems. We will also introduce the current progress in the design of nonviral vectors, and briefly discuss their safety issues.
Abstract 4587: Identification of a monoclonal antibody to treat HCC xenografts with EGFRvIII expression
Authors: Zonghai Li, Hua Jiang, Huamao Wang, Bizhi Shi
Journal: Cancer Research (2011)

Abstract Purposes:To identify monoclonal antibodies targeting Epidermal Growth Factor Receptor Variant III (EGFRvIII) and their anti-tumor effect on Hepatocellular carcinoma (HCC) with EGFRvIII expression. Procedures: Hybridoma technology was used to prepare monoclonal antibody recognizing EGFRvIII. Anti-tumor effects of several hybridoma clones were examined on HCC xenografts with EGFRvIII expression. Monoclonal antibody with highest growth-suppression effect on HCC was selected. Binding specificity of the antibody was tested by FACS assay. The targeting ability of this antibody was tested by injected the cyanin 5.5 labeled antibody into mice carrying EGFRvIII positive and negative xenografts. Findings: Among the tested monoclonal antibodies, mAb 12H23 has the highest tumor-suppression effect on HCC with EGFRvIII expression. mAb 12H23 bind preferentially to HCC cells with EGFRvIII expression. Cy5.5 labeled mAb 12H23 can significantly accumulate into EGFRvIII positive tumors but not the negative tumors. Conclusion: These data indicate mAb 12H23 is a potential biotherapeutic agent for treating HCC with EGFRvIII expression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4587. doi:10.1158/1538-7445.AM2011-4587
MULTIPLE NEURITIS (NON-DIPHTHERITIC) IN CHILDREN.
Authors: H. M. THOMAS
Journal: JAMA (1907)

Multiple neuritis in children is generally considered a rare condition. In Starr's<sup>1</sup>analysis of 154 cases of multiple neuritis, non-diphtheritic, none of the patients were under 15 years of age. In Remak's<sup>2</sup>series of 94 cases, 9 patients were between 10 and 20 years of age, but none below. Gowers<sup>3</sup>refers to it as extremely uncommon, as does Oppenheim.<sup>4</sup>Sachs<sup>5</sup>considers the question thoroughly and appears to have seen a number of cases, but gives no definite data. Holt<sup>6</sup>speaks of the chief cause of multiple neuritis in children as being diphtheria, although it is occasionally seen after infectious diseases. He states that the metallic poisons rarely cause multiple neuritis in early life, and the same is true of alcohol. He refers to certain cases which have been assigned to simple exposure to cold. Buzzard<sup>7</sup>thinks it probable that a number of cases
Isolated Rupture of the Right Hemidiaphragm With Eventration of the Liver
Authors: Neal W. Salomon
Journal: JAMA (1979)

DIAPHRAGMATIC rupture secondary to blunt trauma has been estimated to occur in approximately 4.5% of patients with several injuries. Lacerations of the left diaphragm are ten to 20 times more common than those on the right side; the difference is often attributed to the protection afforded the right hemidiaphragm by the dome of the right lobe of the liver.<sup>1</sup>Most series report a high incidence of associated injuries,<sup>1,2</sup>notably to the pelvis, spine, brain, and extremities, as well as to the intraabdominal organs. Early diagnosis is often delayed because of the extent of the associated injuries or because of a low index of suspicion. In the acute phase, the diagnosis of rupture of the right hemidiaphragm can be more difficult, as herniation of the liver may often be mistaken for merely an elevated intact diaphragm. We report a case of isolated rupture of the right hemidiaphragm secondary to
Heparin Therapy for Heat Stroke
Authors: CORNELIUS J. CORNELL
Journal: Annals of Internal Medicine (1974)

Letters1 November 1974Heparin Therapy for Heat StrokeCORNELIUS J. CORNELL JR., M.D., SEYMOUR H. FEIN, B.A., BRENDON REILLY, M.D., GIBBONS G. CORNWELL III, M.D., F.A.C.P.CORNELIUS J. CORNELL JR., M.D.Search for more papers by this author, SEYMOUR H. FEIN, B.A.Search for more papers by this author, BRENDON REILLY, M.D.Search for more papers by this author, GIBBONS G. CORNWELL III, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-5-702_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The role of disseminated intravascular coagulation and the fibrinolytic mechanism in heat stroke has been controversial (1-3). We recently observed a 17-year-old male with heat stroke who manifested disseminated intravascular coagulation and recovered after heparin therapy.Our patient was admitted to the hospital having collapsed after several hours of football practice on a hot, humid August evening. He was unresponsive, with a blood pressure of 100/40 mm Hg, pulse of 160, and rectal temperature of 41.1 °C. The skin and mucous membranes were dry. The hematocrit was 56%, leukocyte count was 9700/mm3, and platelets were present in...References1. MEIKLEGRAYBILL AJ: Fibrinolysis and hemorrhage in a fatal case of heat stroke. N Engl J Med 276:911-913, 1967 CrossrefMedlineGoogle Scholar2. SHIBOLETFISHERGILAT SST: Fibrinolysis and hemorrhage in fatal heat stroke. N Engl J Med 266:169-173, 1962 CrossrefMedlineGoogle Scholar3. WEBERBLAKELY MJ: The hemorrhagic diathesis of heatstroke. Lancet 1:1190-1192, 1969 CrossrefMedlineGoogle Scholar4. LEAVELLEMERTENSBOWIE DBE: Staphylococcal clumping on microtiter plates: a rapid, simple method for measuring fibrinogen split products. Am J Clin Pathol 55:452-457, 1971 CrossrefMedlineGoogle Scholar5. MALAMUDHAYMAKERCUSTER NWR: Heat stroke: clinicopathologic study of 125 fatal cases. Milit Surg 99:397-449, 1946 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hematology Section Department of Medicine Dartmouth-Hitchcock Medical Center Hanover, New Hampshire PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAdult Respiratory Distress Syndrome and Disseminated Intravascular Coagulation Complicating Heat StrokeBlood coagulation and fibrinolysis in heat strokeTISSUE FACTOR: A VITAMIN K-DEPENDENT CLOTTING FACTOR?Heat illnessHeparin Therapy for HeatstrokeSHLOMO SHIBOLET, M.D., ZVI FARFEL, M.D. 1 November 1974Volume 81, Issue 5Page: 702-703KeywordsBlood pressureDisseminated intravascular coagulationHeart rateHematocritHeparinMucous membranesPlateletsStrokeTemperature Issue Published: 1 November 1974 PDF DownloadLoading ...
Reflex Control of Sympathetic Activity During Ventricular Tachycardia in Dogs
Authors: Michael L. Smith, Toru Kinugawa, Mark E. Dibner-Dunlap
Journal: Circulation (1996)

Background The determinants of hemodynamic outcome during ventricular tachycardia (VT) are not well understood. In the present study, we addressed the relative contributions of arterial and cardiopulmonary baroreflexes to the sympathetic and arterial pressure responses to VT or ventricular pacing (VP) in dogs with inducible VT. Methods and Results Responses of renal sympathetic nerve activity (RSNA), pulmonary capillary wedge pressure (PCWP), and mean arterial pressure (MAP) to induced VT or VP (220 to 280 beats per minute) were determined in 12 dogs with a healed anteroapical infarction and inducible VT and in 8 control dogs. The responses were determined with all reflexes intact, after selective denervation of either arterial or cardiopulmonary baroreflexes, and after combined denervation. Differences between intact and denervated conditions were used to assess the relative effects of each baroreflex. In the infarct group, responses during VT were comparable to those during VP. RSNA and PCWP increased significantly ( P &lt;.01), whereas MAP decreased significantly ( P &lt;.001) during VT or VP with baroreflexes intact in both groups. The increase in RSNA and the recovery of MAP during sustained VP were greater in the infarct group ( P &lt;.05); in addition, the increase in PCWP was greater in the infarct group ( P &lt;.05). Arterial baroreflex denervation abolished the increased RSNA and recovery of MAP during VP in both groups. After cardiopulmonary baroreflex denervation, the increase in RSNA was augmented in both groups (control group more than infarct group), but recovery of MAP was increased further only in the control group. Conclusions These results suggest that arterial baroreflex-mediated sympathoexcitation plays an important role in determining the hemodynamic outcome during VT, whereas cardiopulmonary baroreflexes play only a modest modulatory role.
Dietary phosphorus is associated with greater left ventricular mass
Authors: Kalani T. Yamamoto, Cassianne Robinson-Cohen, Marcia C. de Oliveira, Alina Kostina, Jennifer A. Nettleton, Joachim H. Ix, Ha Nguyen, John Eng, Joao A.C Lima, David S. Siscovick, Noel S. Weiss, Bryan Kestenbaum
Journal: Kidney International (2013)
Vaccination with Recombinant NY-ESO-1 Protein Elicits Immunodominant HLA-DR52b-restricted CD4+ T Cell Responses with a Conserved T Cell Receptor Repertoire
Authors: Gilles Bioley, Christelle Dousset, Alice Yeh, Bo Dupont, Nina Bhardwaj, Gregory Mears, Lloyd J. Old, Maha Ayyoub, Danila Valmori
Journal: Clinical Cancer Research (2009)

ESO is a tumor-specific antigen with wide expression in human tumors of different histologic types and remarkable spontaneous immunogenicity. We have previously shown that specific T(H)1 and antibody responses can be elicited in patients with no detectable preexisting immune responses by vaccination with rESO administered with Montanide ISA-51 and CpG ODN 7909. The purpose of the present study was to characterize vaccine-induced ESO-specific CD4(+) T cell responses.We generated CD4(+) T cell clones from patient C2, who had the highest CD4(+) T cell response to the vaccine, and analyzed their fine specificity and HLA class II restriction to determine the recognized epitope. We then assessed the response to the identified epitope in all vaccinated patients expressing the corresponding HLA class II allele.We found that ESO-specific CD4(+) T cell clones from patient C2 recognize peptide ESO(119-143) (core region 123-137) presented by HLA-DR52b (HLA-DRB3*0202), a MHC class II allele expressed by about half of Caucasians. Importantly, following vaccination, all patients expressing DR52b developed significant responses to the identified epitope, accounting for, on average, half of the total CD4(+) T cell responses to the 119-143 immunodominant region. In addition, analysis of ESO-specific DR52b-restricted CD4(+) T cells at the clonal level revealed significant conservation of T cell receptor usage among different individuals.The identification of a DR52b-restricted epitope from ESO that is immunodominant in the context of vaccine-elicited immune responses is instrumental for the immunologic monitoring of vaccination trials targeting this important tumor antigen.
SYSTEMIC BLASTOMYCOSIS AND COCCIDIOIDAL GRANULOMA.
Authors: LUDVIG HEKTOEN
Journal: JAMA (1907)

<h3>INTRODUCTION.</h3> Since the description by Gilchrist in 1894 of blastomycetic dermatitis numerous instances of this infection have been recorded by American observers. The clinical course, the characteristic double-contoured, budding organisms, and the distinctive gross and microscopic anatomy—especially the marked epithelial hyperplasia, the minute epidermal abscesses, and the peculiar granulomatous infiltration of the corium—early established the entity of blastomycetic dermatitis so firmly that denial of its existence, especially by certain German writers, never has received serious notice. H. G. Wells discovered the first case in Chicago, and the large number of cases observed in this city, especially by Professor Hyde and his associates, is noteworthy. Whether this apparent relative frequency of the disease here is in any way due to accidental conditions or to our being in the midst of an especially heavily infested territory remains to be seen. The interest in blastomycetic infection enlarged when it became known that this
Serotonin S2and thromboxane A2-prostaglandin H2receptor blockade provide protection against epinephrine-induced cyclic flow variations in severely narrowed canine coronary arteries
Authors: Juliet H. Ashton, Paolo Golino, Janice M. McNatt, L.M. Buja, James T. Willerson
Journal: Journal of the American College of Cardiology (1989)
Neurochemistry and toxicology: overview.
Authors: T Damstra
Journal: Environmental Health Perspectives (1978)

We have witnessed a tremendous increase in our knowledge of the molecular and biochemical mechanisms which underly the activities of the nervous system. Such knowledge is essential in order to determine the basic mechanisms involved in neurotoxic events. An overview of how neurotoxins could conceivably interfere with some basic neurochemical processes is presented, along with a specific example of how an understanding of such processes can contribute to the detection of neurotoxicity and to the development of predictive testing techniques.
Residential Treatment for the Disturbed Child: Basic Principles in Planning and Design of Programs and Facilities
Authors: Stuart M. Finch
Journal: JAMA (1961)

ABSTRACT This is a well-written and reasonably comprehensive book which deals with the basic principles in planning and in design of programs for the residential  of disturbed children. The author, director of the Hawthorne Cedar Knolls School since 1941, devotes a good deal of the book to describing the past, the present, and some of the future hopes of his institution. This school has long been known for its pioneering efforts in the  of disturbed children, and its history is illuminating in regard to the many problems in this field of endeavor. Gradually over the years a therapeutic atmosphere replaced the older orientation and the move from training to treatment was really established in 1935. For the next 10 years there was an elaboration of this therapeutic orientation, with attempts to reconcile the old and the new methods. From 1945 on, there was still further elaboration of the
Molecular Biology of Renal Cell Cancer and the Identification of Therapeutic Targets
Authors: Othon Iliopoulos
Journal: Journal of Clinical Oncology (2006)

Renal cell cancer (RCC) is a heterogeneous disease consisting of different histologic types. Major advances have been accomplished during the last 15 years in our understanding of the genetic events that initiate RCC. These advances were greatly facilitated by meticulous clinical description and registration of patients with familial predisposition to RCC. The cloning of the susceptibility genes that underline familial predisposition to RCC has offered entry points into the signaling pathways that are also deregulated in sporadic RCC. Biochemical studies of these signaling pathways and target validation experiments have already culminated in the discovery and clinical application of small molecules with promising activity in RCC. In this article, we highlight the molecular genetic features of RCC that are more directly related to identification and validation of promising targets for molecular therapy.
ASSOCIATION OF PARVOVIRUS B19 INFECTION WITH CARDIAC AMYLOIDOSIS AND MYOCARDIAL DISEASES POSITIVE FOR AMYLOID FIBRILS AT ELECTRON MICROSCOPY
Authors: Maria L. Higuchi, Dirk Lassner, Edimar Bocchi, Charles Mady, Heinz-Peter Schultheiss, José AF Ramires, Uwe Kühl
Journal: Journal of the American College of Cardiology (2010)
Post-induction residual leukemia in childhood acute lymphoblastic leukemia quantified by PCR correlates with in vitro prednisolone resistance
Authors: K Schmiegelow, C Nyvold, J Seyfarth, R Pieters, MMA Rottier, N Knabe, LP Ryder, HO Madsen, A Svejgaard, GJL Kaspers
Journal: Leukemia (2001)
Non-tuberculous mycobacteria in end stage cystic fibrosis: implications for lung transplantation
Authors: W Chalermskulrat, N Sood, I P Neuringer, T M Hecker, L Chang, M P Rivera, L J Paradowski, R M Aris
Journal: Thorax (2006)

<b>Background:</b> WC and NS contributed equally. Non-tuberculous mycobacteria (NTM) frequently colonise patients with end stage cystic fibrosis (CF), but its impact on the course of the disease following lung transplantation is unknown. <b>Methods:</b> Lung transplant recipients with CF who underwent lung transplantation at our institution between January 1990 and May 2003 (n = 146) and CF patients awaiting lung transplantation in May 2003 (n = 31) were studied retrospectively. <b>Results:</b> The prevalence rate of NTM isolated from respiratory cultures in patients with end stage CF referred for lung transplantation was 19.7%, compared with a prevalence rate of 13.7% for NTM isolates in CF lung transplant recipients. The overall prevalence of invasive NTM disease after lung transplantation was low (3.4%) and was predicted most strongly by pre-transplant NTM isolation (p = 0.001, Fisher's exact test, odds ratio (OR) 6.13, 95% CI 3.2 to 11.4). This association was restricted to <i>Mycobacterium abscessus</i> (p = 0.005, Fisher's exact test, OR 7.45, 95% CI 2.9 to 16.9). While NTM disease caused significant morbidity in a small number of patients after transplantation, it was successfully treated and did not influence the post-transplant course of the disease. <b>Conclusion:</b> The isolation of NTM before transplantation in CF patients should not be an exclusion criterion for lung transplantation, but it may alert the clinician to patients at risk of recurrence following transplantation.