tbuckley/cabot-search huggingface dataset:
Generalized Eruptive Histiocytosis Associated With<i>FIP1L1-PDGFRA</i>–Positive Chronic Eosinophilic Leukemia
Authors: Birgit Ziegler, Wiebke K. Peitsch, Andreas Reiter, Alexander Marx, Sergij Goerdt, Cyrill Géraud
Journal: JAMA Dermatology (2015)

Generalized eruptive histiocytosis (GEH) is a rare non-Langerhans cell histiocytosis with a benign, self-healing course. Neoplastic hematologic disorders of the myeloid lineage have been reported in association with GEH in 4 patients. A clonal association between GEH and the underlying leukemia was suspected in these patients but could only be confirmed in one patient.A male patient in his 20s presented with asymptomatic red to brown macules and papules. A skin biopsy confirmed a diagnosis of GEH. His blood cell count revealed hypereosinophilia. Morphologic and molecular analyses from bone marrow and blood samples revealed FIP1L1-PDGFRA-positive chronic eosinophilic leukemia. The patient was treated with imatinib and achieved complete clinical remission of his leukemia and the GEH.To our knowledge, this is the first report of a patient with GEH associated with FIP1L1-PDGFRA-positive chronic eosinophilic leukemia. Generalized eruptive histiocytosis in association with a myeloid neoplasm may occur in 2 variants: a reactive condition or a clonal derivative of the underlying leukemia. In this case, both diseases responded well after initiation of treatment with imatinib.
A CASE OF CYST OF THE INTESTINE
Authors: C. Bolton, T. W. P. Lawrence
Journal: BMJ (1916)

TAUG. I9, I9I6the point of the instrument is cut down uipon in the perineunm.Blood clot, irr-eparably damaged tissue, and foreign natter are removed, haemorrhagge is arrested, auid free drainage is established after thoroughl cleansinig of the wound.The patient is niow encouraged to pass hiis urine througlh the wound, hlot com-presses being used to relax h1is sphincter if necessary.If at first failur-e to pass urine should occtr, it is better, in my opinion, to aspirate tie bladder through lhealtliy tissues above the pubes than to poke about in the periueal wound in tlle hiope of findling tlie proximual end of the uretlhra or infect the healthy bladder by an instrumilent passed througlh a septic wound.Wlhen the sepsis has been controlled, dilatation, if neces- sary, can be carried out, and, later, plastic operations can be successfully attempted.Here again tlhe uLor;,nal urine of the patient acts as an eflin lasj lQfPt, sz)2 hn ,,>\ hIis wound froin the depths otwtard every time lie mictturates.'Trearedi on thlese lines cases of tlhis sort lheal witlh the greatest rapidity.The followinig two cases will illustrate some of thie points I h1ave tried to make.CASE V. Pte.J. W. H. was wounded on September 28th, 1915.A bullet enitered the riglht groin ia the region of the exterual al-dominal ring anid, passing obliquiely across the pelvis, lodged in th)e left ischio-rectal fossa.A catheter was tied in at tlle front and the patienit was passed oi.He was admitted to a base hospital on September 30th under the care of Captain Wolfendein.He was then in a toxic con- dition, though the temperature was only 990 and the pulse 100.He complained of pain and tenderness in the suprapubic region.No urine waspassing throtu th the catheter though the bladder was full.There was ecciymosis of the perinetum but no extravasation of urine.On October lst the patient had a rigor, and Captain Wol.e-lden asked me to see himn.We decided on perineal section.Captain Wolfenden accordingly explored the perineum, and found the bulbous urethra lacerate(d and a portion of the corp-Lus
Computer detection of atrioventricular dissociation from surface electrocardiograms during wide QRS complex tachycardias.
Authors: J Slocum, E Byrom, L McCarthy, A Sahakian, S Swiryn
Journal: Circulation (1985)

Differentiation of wide QRS complex tachycardias on surface electrocardiograms is difficult for physicians and computers due in part to their inability to identify atrial activity, specifically atrioventricular (AV) dissociation. We studied 20 examples of AV associated rhythms and 17 examples of AV dissociated ventricular tachycardia. We applied an algorithm consisting of subtraction of a mean beat from each individual beat in leads II and V1 to generate remainder electrocardiograms. The remainder electrocardiograms were visually inspected for the presence of P wave candidates and then autocorrelated. AV dissociated P wave candidates were evident on visual inspection of remainder electrocardiograms in none of 20 AV associated and 15 of 17 AV dissociated rhythms. Atrial cycle length and the presence of AV dissociation were automatically detected by applying a peak selection algorithm to the autocorrelation function. AV association was detected in all 20 AV associated rhythms and AV dissociation was detected for 11 of 17 AV dissociated rhythms (sensitivity 65%, specificity 100%, positive and negative predictive accuracy 100%, 77%). The correlation coefficient of detected vs true atrial cycle length for the 11 correctly detected AV dissociated rhythms was r = .98. Visual inspection of the remainder electrocardiograms along with the original electrocardiogram may increase the ease with which human readers can identify the presence of AV dissociation and thus diagnose ventricular tachycardia. Computer diagnosis of wide QRS complex tachycardias should be significantly improved by use of this algorithm.
In vivo synergism between chemotherapy and the 3C23K monoclonal antibody targeting the AMH-type II receptor in ovarian cancer PDX models
Authors: F. Nemati, J.-M. Barret, G. Massonnet, H. Bougherara, A. Nicolas, E. Martel, E. Donnadieu, J. Prost, D. Decaudin
Journal: Annals of Oncology (2015)
The new oral antifungal drugs in the treatment of the yellow nail syndrome
Authors: R. Baran
Journal: British Journal of Dermatology (2002)

Journal Article The new oral antifungal drugs in the treatment of the yellow nail syndrome Get access R. Baran R. Baran Nail Disease Centre, 42 rue des Serbes, 06400 Cannes, France E‐mail: baran.r@club‐internet.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 147, Issue 1, 1 July 2002, Pages 180–195, https://doi.org/10.1046/j.1365-2133.2002.48119.x Published: 01 July 2002
The use of calcium phosphate nanoparticles encapsulating Toll-like receptor ligands and the antigen hemagglutinin to induce dendritic cell maturation and T cell activation
Authors: Viktoriya Sokolova, Torben Knuschke, Anna Kovtun, Jan Buer, Matthias Epple, Astrid Maria Westendorf
Journal: Biomaterials (2010)
Correlation of Left Ventricular Ejection Time with Stroke Index in Patients with Acute Myocardial Infarction.
Authors: Alfred J. Rufty
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Correlation of Left Ventricular Ejection Time with Stroke Index in Patients with Acute Myocardial Infarction.Alfred J. Rufty Jr., M.D., Barry W. Ramo, M.D., Andrew G. Wallace, M.D., F.A.C.P., Robert E. Whalen, M.D., F.A.C.P., Henry D. McIntosh, M.D., F.A.C.P., David O. ClarkAlfred J. Rufty Jr., M.D.Search for more papers by this author, Barry W. Ramo, M.D.Search for more papers by this author, Andrew G. Wallace, M.D., F.A.C.P.Search for more papers by this author, Robert E. Whalen, M.D., F.A.C.P.Search for more papers by this author, Henry D. McIntosh, M.D., F.A.C.P.Search for more papers by this author, David O. ClarkSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-780_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe need for a simple, non-invasive technique for evaluating ventricular function in patients with acute myocardial infarction is apparent. The usefulness of the easily determined left ventricular ejection time as an indication of stroke index in patients with stable circulatory systems has been documented by other investigators. The present study was designed to determine whether such a relationship also exists in patients with acute myocardial infarction.The left ventricular ejection time was determined simultaneously with cardiac output (indicator dilution) and heart rate in 18 patients with acute myocardial infarction. The ejection time was measured in 11 of the patients from... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Durham, N.C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Systolic Time Intervals in Myocardial Infarction 1 May 1970Volume 72, Issue 5Page: 780-780KeywordsAcute myocardial infarctionCardiac outputHeart rateMyocardial infarctionStroke Issue Published: 1 May 1970 PDF downloadLoading ...
Economics of the Health Service
Authors: J. V. Sowton
Journal: BMJ (1968)

<h3>Background</h3> Pakistan has a large population of tobacco users, with about 24 million adults consuming tobacco products in one form or another. There is a dearth of research on the impact of a reduction in tobacco use on Pakistan’s economy which can inform policy-makers on the extent that tobacco control measures would affect macroeconomic indicators such as output and employment. <h3>Objectives</h3> The objective of this study is to quantify the changes in output, income and employment resulting from changes in cigarette consumption and to quantify the impact of such changes on the overall economy. <h3>Methodology</h3> The study uses the input–output table for the fiscal year 2010–2011 for Pakistan’s economy, to estimate the output, income and employment multipliers. The Leontief input–output model is used to estimate the sectorwise multiplier effects. It estimates direct, indirect and consumption-induced effects of changes in tobacco use on the economy. <h3>Results</h3> The cigarette industry’s share in large-scale manufacturing and industrial employment is 1.1% and 0.3%, respectively. The estimates of gross output, income and employment multipliers for the cigarette industry have relatively small magnitudes indicating minimal impact on the economy. A simulation analysis based on the latest estimates of price elasticity of cigarette and input–output multipliers, shows that a 10% increase in price will lead to an 11% reduction in cigarette consumption, which translates into annual savings of Pakistani Rupees (Rs) 16 billion by households. Reduction in cigarette consumption will allow individuals to spend their savings on other commodities. For example, spending this amount on food items will lead to a net increase of Rs 40 billion annual output of the economy. <h3>Conclusion</h3> Reduction in tobacco consumption will lead to initial losses to the economy but there will be considerable gains in output, employment and income due to redistribution of tobacco expenditures.
Abstract 260: Identification of the role of linker histone H1 in estrogen receptor binding and activity
Authors: Laura Cato, Myles Brown
Journal: Cancer Research (2011)

Abstract The activity of estrogen receptor (ER) in the nucleus is a highly dynamic process, which is tightly regulated by many factors. Among the molecules proposed to facilitate ER activity are proteasome components, chromatin-remodeling complexes, heat shock proteins and histones. Particularly the linker histone H1 seems important, as it is essential to the stability of the higher-order chromatin structure and has been associated with the regulation of gene expression for many years. Eleven linker histones have been identified in humans to date, differing in their timing of expression, extent of post-translational modification and affinity to DNA in chromatin. However, their exact function and ability to differentially affect gene expression are not as clearly understood. It seems probable that linker histones need to be removed, reduced in amount or somehow modified during transcription in order to allow access to the transcription machinery and that these processes are different for the different linker histone subtypes. Here we show that removal of linker histone H1 is a prerequisite for the full activation of ER-regulated target genes in ER positive breast cancer cells. This process is mediated through the activity of the cyclin-dependent kinase 2 (CDK2), which phosphorylates H1 in a hormone-dependent manner, and thereby loosens the interaction of the linker histone with DNA in chromatin. The extent of phosphorylation differs significantly between the different subtypes, suggesting a differential involvement of the H1s in ER-mediated gene expression. Collectively, our results show that H1 dissociation is required for ER-mediated gene expression in breast cancer and that the H1 subtypes may play distinct functional roles in the transcriptional regulation of ER target genes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 260. doi:10.1158/1538-7445.AM2011-260
Human numbers, environment, sustainability, and health
Authors: A J McMichael, J W Powles
Journal: BMJ (1999)

The complex relationships between economic development, population size, environmental conditions, and health have long stimulated discussion Usually, however, health has not been regarded as the primary outcome of interest. For example, a prominent paper published in 1967, entitled “Health, population and economic development,” examined various inter-relationships between these three variables—with the exception of how population growth or economic development affected health.1 Similarly, the much quoted report of the World Commission on Environment and Development of 1987 paid little attention to how environmental and economic changes affect population health.2

There is need for a more critical assessment of the ecological conditions under which health gains might be both generalised to the whole human population and sustained into the future.

#### Summary points

The rapid increase in population which began about two centuries ago has slowed since the 1960s, and stabilisation at around 10-11 billion is now expected

The disruption of natural systems on a global scale now seems a more serious potential harm from excessive numbers than does the occurrence of local difficulties in subsistence

The prospect of further intensification of ecologically disruptive economic activity means that paths to sustainability will require a shared radical “greening” of productive technologies and consumption habits

The main practical need, in the short term, is for indicators of ecological and social sustainability

There will be substantial scope for improving population health at any level of national income, by developing social and human, rather than material, resources

We have familiarity with the scientific literature on population biology, the history of human ecology, and global environmental change and its potential health consequences. We consulted mainstream authoritative texts on these topics. The extensive literature on climate change was accessed through publications of the Intergovernmental Panel on Climate Change. Demographic, economic, and other characteristics for national populations are taken from …
Drug Adherence and Clinical Outcomes for Patients Under Pharmacological Therapy for Lower Urinary Tract Symptoms Related to Benign Prostatic Hyperplasia: Population-based Cohort Study
Authors: Luca Cindolo, Luisella Pirozzi, Caterina Fanizza, Marilena Romero, Andrea Tubaro, Riccardo Autorino, Cosimo De Nunzio, Luigi Schips
Journal: European Urology (2014)
"SHE THOUGHT IT WAS HER CHANGE OF LIFE."REPORTING CASES OF UTERINE POLYPI, UTERINE CANCER, INVERSION OF UTERUS AND SUB-PERITONEAL FIBROID. Read by Title in the Section of Obstetrics and Gynecology, at the Forty-first Annual Meeting of the American Medical Association, at Nashville, Tenn., June, 1890.
Authors: A. VANDERVEER
Journal: JAMA (1890)

The object of this paper is to concentrate upon certain cases that occur in our consultation practice, and in the practice of the overworked general practitioner, a closer and more positive examination for the purpose of a correct diagnosis. I will proceed at once to the report of a case that will help to illustrate what I have in mind. Miss M., æt. 47, a well-to-do maiden lady residing in a small country town, had been in good health, regular in her menstruation up to the age of 44, when she began to flow more excessively at her menstrual periods, and soon thereafter developed a condition of both menorrhagia and metrorrhagia. After this condition had lasted for a year, and when she was quite anæmic, somewhat exhausted and losing in flesh, she consulted her family physician, Dr. B., who treated her for some time with tonics, rest and diet, with
Exploring the Heart: Discoveries in Heart Disease and High Blood Pressure
Authors: Rex N. MacAlpin
Journal: JAMA (1984)

In this fascinating book, the late Dr Comroe has traced the major threads of scientific and medical research that culminated in some of the most important modern advances in cardiovascular medicine and surgery. The writing is purposely directed at the general public, but much of the book contains material probably unknown even to cardiologists and cardiovascular surgeons. For many years the author was director of the Cardiovascular Research Institute at the University of California, San Francisco, and he has actively pursued studies on how breakthroughs in medical research have come about. This book reflects his thoughtful interpretation of the history of some breakthroughs impinging on cardiovascular disease, and it is enlivened by new material derived from personal interviews he had with some of the scientists and physicians whose work the book covers. The first half of the book deals with the history of those medical advances that were essential before
An ADDRESS on the PATHOLOGY of ANTENATAL LIFE: Delivered before the Glasgow Obstetrical and Gynaecological Society
Authors: J. W. Ballantyne
Journal: BMJ (1898)

JUNE rl, u8g8W 4. The want of adaptability of the patient to his surround- ings.5. Overcrowding in ill-constructed and ill-planned houses.6. Second-rate food and wine.7. The want of reliable English doctors.These deficiencies it is the province of this Society to lessen and remove.Already your excellent Journal is di- seminating a large amount of useful knowledge, and I havp no doubt that the real wants of our expatriated invalids will be adequately provided if they should receive distinct utter ance at the hands of a powerful Society like this.
THE MENACE OF MENTAL FACTORS IN BODILY DISEASES
Authors: CORNELIUS C. WHOLEY
Journal: JAMA (1930)

Medical and surgical conditions are often imitated and exaggerated by mental causes. This circumstance constitutes a menace in diagnosis and treatment. Stevenson<sup>1</sup>recently found in a large medical clinic that 19 per cent of the patients who came to the gastro-intestinal specialist had severe emotional problems, and that in only one fourth of the cases were mental or emotional disturbances absent. In 16 per cent of the children brought to the pediatric clinic, emotional factors arising in the home were responsible for the disorders in the children. A vast amount of evidence has accumulated to show that mental conflicts and emotional disturbances upset the normal physiologic functions of the vegetative or sympathetic system. This system, as is known, regulates secretion, circulation, digestion and respiration. If it is disturbed, functional disability takes place in the viscera associated with these functions, such as kidneys, heart and stomach. When this functional upset
Nephrotic Syndrome in Hodgkin's Disease.
Authors: Raymond L. Sherman
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Nephrotic Syndrome in Hodgkin's Disease.Raymond L. Sherman, M.D. (Associate), George P. Sartiano, M.D., Vincent P. Vinciguerra, M.D., E. Lovell Becker, M.D., F.A.C.P.Raymond L. Sherman, M.D. (Associate)Search for more papers by this author, George P. Sartiano, M.D.Search for more papers by this author, Vincent P. Vinciguerra, M.D.Search for more papers by this author, E. Lovell Becker, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-805_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIdiopathic lipoid nephrosis usually does not complicate other diseases. Recently two patients presenting with the nephrotic syndrome without evidence of amyloidosis or renal vein thrombosis were found to have Hodgkin's disease.Patient R.G., a 21-year-old white man, developed severe nephrotic syndrome in May 1968 and 2 months later was admitted to The New York Hospital where he was noted to have a creatinine clearance (CCR) of 40 ml/min and urine protein excretion of 29 g/24 hr. Renal biopsy was normal by light microscopy, and immunofluorescent antibody staining was negative. Biopsy of an enlarged cervical lymph node showed Hodgkin's disease. He... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Raymond L. Sherman, M.D. (Associate); George P. Sartiano, M.D.; Vincent P. Vinciguerra, M.D.; E. Lovell Becker, M.D., F.A.C.P.Affiliations: New York, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntraglomerular metastases. Report of two casesNephrotic syndrome associated with T-cell lymphomaHodgkin's disease complicated by the nephrotic syndromeMalignant lymphoma and nephrotic syndromeCase 52-1972IMMUNOLOGICAL STUDIES IN NEPHROTIC SYNDROME ASSOCIATED WITH EXTRARENAL MALIGNANT DISEASEGLOMERULONEPHRITIS OR NEPHROTIC SYNDROME IN MALIGNANT LYMPHOMA, RETICULUM-CELL TYPE 1 May 1970Volume 72, Issue 5Page: 805-805KeywordsBiopsyCreatinineExcretionHodgkin lymphomaImmunofluorescence stainingLight microscopyLymph nodesProteinsUrineVeins ePublished: 1 December 2008 Issue Published: 1 May 1970 PDF downloadLoading ...
Illinois assembly votes to abolish death penalty, but governor hesitates
Authors: J. H. Tanne
Journal: BMJ (2011)

The Illinois House of Representatives and Senate have voted to repeal the state’s death penalty, but the state’s newly elected governor, Pat Quinn, a Democrat, has not yet signed the bill into law.

Governor Quinn said on 12 January that he would follow his conscience in deciding whether to sign. He has 60 days to decide. During his election campaign he supported the death penalty but said he would maintain the state’s current moratorium on executions.

If he signs the bill Illinois will become the 16th state to outlaw executions.

Two men, Kevin Fox and Jerry Hobbs, who were wrongly accused of murdering their children but cleared by …