tbuckley/cabot-search huggingface dataset:
Heart/Lung Recipient Becomes First Living Heart Donor in United States
Authors: Beverly Merz
Journal: JAMA (1987)

"TAKE MY HEART!" Although millions of men in the United States may have uttered this phrase, only one has meant it literally. He is Clinton House, a 28-year-old patient with cystic fibrosis, who, in receiving a heart/lung graft from an accident victim, became cardiac donor to 38-year-old John Couch, a patient with ischemic cardiomyopathy. The procedures, which were performed by surgical teams at Johns Hopkins Medical Center in Baltimore under the direction of William A. Baumgartner, MD, and Bruce Reitz, MD, marked the first time in the United States that a heart transplant recipient's own heart was recycled. A public information officer at Harefield Hospital near London reported that surgeons at that hospital had performed two similar operations in April and early May. Baumgartner, who is director of heart/lung transplantation at the US center, and Reitz, who is director of cardiovascular surgery, were among those who pioneered heart/lung transplantation at
Impersonalism in Bioethics
Authors: Robert Ranisch
Journal: The American Journal of Bioethics (2012)

Click to increase image sizeClick to decrease image size Acknowledgments 1. Hope and McMillan do not use this terminology. Yet when they argue that our actions can fail to bring about the “best state of affairs” or the “best state of the world,” they argue from an impersonalist perspective. 2. There are actually distinct claims at stake here. One claim is about the person-affecting nature of value, and the other claim is about a specific comparative notion of harm. Even though it is worth distinguishing the two claims, I follow Hope and McMillan in not discussing them separately.
Variation in interleukin 7 receptor α chain (IL7R) influences risk of multiple sclerosis
Authors: Frida Lundmark, Kristina Duvefelt, Ellen Iacobaeus, Ingrid Kockum, Erik Wallström, Mohsen Khademi, Annette Oturai, Lars P Ryder, Janna Saarela, Hanne F Harbo, Elisabeth G Celius, Hugh Salter, Tomas Olsson, Jan Hillert
Journal: Nature Genetics (2007)
Role of Imaging in the Diagnosis of Occult Hernias
Authors: Joseph Miller, Janice Cho, Meina Joseph Michael, Rola Saouaf, Shirin Towfigh
Journal: JAMA Surgery (2014)

Occult hernias are symptomatic but not palpable on physical examination. This is more commonly seen with inguinal hernias. Early diagnosis and treatment of occult hernias are essential in relieving symptoms and improving patients' quality of life.To determine the effectiveness of imaging-ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI)--in the diagnosis of occult inguinal hernia.A retrospective medical records review of surgical patients with groin and pelvic pain, 2008-2013, was conducted in a single-surgeon hernia specialty practice. Thirty-six patients met the following inclusion criteria: (1) examination findings suggestive of but not necessarily diagnostic for inguinal hernia; (2) imaging of the groin and/or pelvis with US, CT, and MRI; and (3) an operation to address the groin or pelvic pain. Fifty-nine groins were included.Sensitivity, specificity, and predictive values of US, CT, and MRI for detection of occult inguinal hernia.The number, sensitivity, specificity, positive predictive value, and negative predictive value of each modality were, respectively: US (9, 0.33, 0, 1.00, and 0), CT (39, 0.54, 0.25, 0.86, and 0.06), and MRI (34, 0.91, 0.92, 0.95, and 0.85). Among multiply imaged groins in which CT examination missed a diagnosis of hernia, MRI correctly detected an occult hernia in 10 of 11 cases (91%).Ultrasonography and CT cannot reliably exclude occult groin abnormalities. Patients with clinical suspicion of inguinal hernia should undergo MRI as the definitive radiologic examination.
Endoscopic Dilatation and Papillotomy of the Accessory Papilla and Internal Drainage in Pancreas Divisum
Authors: N. Soehendra, I. Kempeneers, V.Ch. Nam, H. Grimm
Journal: Endoscopy (1986)

In the case of pancreas divisum the minute orifice of the minor papilla has offered a special challenge to endoscopic diagnosis and therapy. Here we describe a method for easy cannulation of the minor papilla and drainage of the pancreatic duct. By means of a flexible guide wire and a dilator, the tiny papilla can be simply dilated, enabling papillotomy to be successfully accomplished. This method has been used in six cases without any major complications, and should pave the way for diagnosis and therapy of pancreas divisum.
Sodium-Hydrogen Exchange Inhibition During Ventricular Fibrillation
Authors: Iyad M. Ayoub, Julieta Kolarova, Zhong Yi, Atul Trevedi, Hanumant Deshmukh, David L. Lubell, Michael R. Franz, Frank A. Maldonado, Raúl J. Gazmuri
Journal: Circulation (2003)

Inhibition of the sarcolemmal sodium-hydrogen exchanger isoform-1 (NHE-1) is emerging as a promising novel strategy for ameliorating myocardial injury associated with ischemia and reperfusion. We investigated whether NHE-1 inhibition (with cariporide) could minimize mechanical and electrical myocardial abnormalities that develop during ventricular fibrillation (VF) and improve outcome using a porcine model of closed-chest resuscitation.Two groups of 8 pigs each were subjected to 8 minutes of untreated VF and randomized to receive either a 3-mg/kg bolus of cariporide or 0.9% NaCl immediately before an 8-minute interval of conventional closed-chest resuscitation. Cariporide prevented progressive increases in left ventricular free-wall thickness (from 1.0+/-0.2 to 1.5+/-0.3 cm with NaCl, P<0.001 versus 0.9+/-0.1 to 1.1+/-0.3 cm with cariporide, P=NS), maintained the coronary perfusion pressure above resuscitability thresholds (10+/-8 versus 19+/-3 mm Hg before attempting defibrillation, P<0.05), and increased resuscitability (2 of 8 versus 8 of 8, P<0.005). In 2 additional groups of 4 pigs each subjected to a briefer interval of untreated VF, cariporide ameliorated postresuscitation shortening of the action potential duration (APD) at 30%, 60%, and 90% repolarization (ie, APD60 at 2 minutes after resuscitation; 75+/-29 versus 226+/-16 ms, P<0.05), minimized postresuscitation ventricular ectopic activity preventing recurrent VF, and lessened postresuscitation myocardial dysfunction.NHE-1 inhibition may represent a highly potent novel strategy for resuscitation from VF that can ameliorate myocardial manifestations of ischemic injury and improve the effectiveness and outcome of closed-chest resuscitation.
c-Myb and its target Bmi1 are required for p190BCR/ABL leukemogenesis in mouse and human cells
Authors: T Waldron, M De Dominici, A R Soliera, A Audia, I Iacobucci, A Lonetti, G Martinelli, Y Zhang, R Martinez, T Hyslop, T P Bender, B Calabretta
Journal: Leukemia (2011)
'Tis all in pieces (separate RFs and CFs), all coherence gone
Authors: Ernst Neibur, Marius Usher
Journal: Behavioral and Brain Sciences (1997)

We argue that the separation between CF (contextual field) and RF (receptive field) in relation to the NMDA (N-methyl-D-aspartate) system is empirically questionable and that it is functionally unnecessary. In addition, the proposed suppression of unexpected information will in many cases be counterproductive.
Definition, reporting, and interpretation of composite outcomes in clinical trials: systematic review
Authors: G. Cordoba, L. Schwartz, S. Woloshin, H. Bae, P. C. Gotzsche
Journal: BMJ (2010)

<h3>Background</h3> Malawi is among the 5 sub-Saharan African countries presenting with very high maternal mortality rates, which remain a challenge. This study aims to examine the impact of wealth inequality and area of residence (urban vs rural) and education on selected indicators of maternal healthcare services (MHS) usage in Malawi. <h3>Methods</h3> This study was based on data from the 5th round of Multiple Indicator Cluster Surveys (MICS) conducted in 2013–2014 in Malawi. Study participants were 7572 mothers aged between 15 and 49 years. The outcome variable was usage status of maternal health services of the following types: antenatal care, skilled delivery assistance and postpartum care. Univariate, bivariate and multivariate methods were used to describe the pattern of MHS usage in the sample population. Association between household wealth status, education as well as the type of residence, whether urban or rural, as independent variables and usage of MHS as dependent variables were analysed using the generalised estimating equations (GEE) method. <h3>Results</h3> Mean age of the sample population was 26.88 (SD 6.68). Regarding the usage of MHS, 44.7% of women had at least 4 ANC visits, 87.8% used skilled delivery attendants and 82.2% of women had used postnatal care. Regarding the wealth index, about a quarter of the women were in the poorest wealth quintile (23.6%) while about 1/6 were in the highest wealth quintile (15%). Rate of usage for all 3 types of services was lowest among women belonging to the lowest wealth quintile. In terms of education, only 1/5 completed their secondary or a higher degree (20.1%) and nearly 1/10 of the population lives in urban areas (11.4%) whereas the remaining majority live in rural areas (88.6%). The rates of usage of MHS, although reasonable on an overall basis, were consistently lower in women with lower education and those residing in rural areas. <h3>Conclusions</h3> Maternal health service usage in Malawi appears to be reasonable, yet the high maternal mortality rate is disturbing and calls for analysing factors hindering the achievement of maternal health-related Sustainable Development Goals (SDGs). The findings of this study underscore the need to minimise the wealth inequality, urban–rural divide and the low level of education among mothers to improve the usage of MHS. An equity-based policy approach considering the sociodemographic inequity in terms of wealth index, education and urban–rural divide might prove beneficial in further improving the MHS usage, as well as addressing the possible issues of quality gaps in MHS, which might be beneficial towards reducing maternal mortality. It should be noted that the study of quality gaps in MHS is beyond the scope of this paper and calls for further research in this arena.
PASD1 is a potential multiple myeloma–associated antigen
Authors: Surinder S. Sahota, C. Madusha Goonewardena, Christopher D. O. Cooper, Amanda P. Liggins, Kamal Ait-Tahar, Niklas Zojer, Freda K. Stevenson, Alison H. Banham, Karen Pulford
Journal: Blood (2006)
Intraperitoneal Administration of Broad-Spectrum Antibiotics in Patients With Renal Failure
Authors: Roger J. Bulger
Journal: JAMA (1965)

Broad-spectrum antibiotics (cephalothin, ampicillin, tetracycline, and two forms of chloramphenicol) were administered intraperitoneally during peritoneal dialysis to patients with essentially no renal function. Significant serum levels were obtained with all drugs tested except chloramphenicol succinate. Despite continuing intraperitoneal administration for 18 to 32 hours, all drugs except tetracycline demonstrated a leveling off of serum levels. The dangers of administration of tetracycline during peritoneal dialysis are emphasized. The dynamics of peritoneal absorption, pharmacology, and toxicity are discussed and recommendations are made regarding choice and dosage of appropriate antibiotics.
Malignant Lymphoma With Prostate Involvement Detected by Ga-67 Scintigraphy
Authors: Chun-Yi Lin, Shung-Shung Sun, Feng-Ju Chuang, Chia-Hung Kao
Journal: Clinical Nuclear Medicine (2004)

Ga-67 is the classic radionuclide for detecting malignant lymphoma. Involvement of the prostate by malignant lymphoma is rare. In the current report, the authors describe an unusual case of malignant lymphoma with prostate involvement detected by Ga-67 scintigraphy.
Preoperative prediction of postoperative deep vein thrombosis.
Authors: J K Clayton, J A Anderson, G P McNicol
Journal: BMJ (1976)

A range of clinical data was obtained from 124 patients about to undergo operation and several coagulation tests were performed. No patient received prophylaxis for deep vein thrombosis, and isotopic scanning after operation showed that 20 patients had developed thrombosis. a simiple prognostic index for predicting which patients would develop postoperative deep vein thrombosis was constructed using the clinical and coagulation data obtained before operation. The five variables with the best predictive power-euglobulin lysis time, age, presence of varicose veins, fibrin related antigen, and percentage overweight-produced an equation that identfied 95% of those who developed deep vein thrombosis and misallocated only 28% of those who did not develop thrombosis. In view of the complications that low-dose heparin and dextran can cause, giving prophylaxis to under a third of the patients who will not develop deep vein thrombosis is clearly better than giving it to all.
Lung Perfusion Imaging in Electromechanical Dissociation from Massive Pulmonary Embolization
Authors: GINO DllORIO, HENRY M. GOODGOLD
Journal: Clinical Nuclear Medicine (1992)

A 70-year-old woman became acutely short of breath and suffered cardiopulmonary arrest 1 week after left upper lobectomy for carcinoma of the lung. Normal sinus rhythm was restored but no pulse or blood pressure could be detected (electromechanical dissociation). She was placed on ECMO (extracorporeal membrane oxygenation), and lung perfusion imaging was performed to look for pulmonary emboli. The patient was unable to maintain a pulse or pressure without ECMO and after several hours was allowed to die. At autopsy, diffuse, scattered, large pulmonary emboli were found.
Self-reported skin morbidity in Oslo. Associations with sociodemographic factors among adults in a cross-sectional study
Authors: F. Dalgard, A. Svensson, J.O. Holm, J. Sundby
Journal: British Journal of Dermatology (2004)

Background Previous studies on prevalence of skin diseases in the population have been based on clinical examination of a sample of the population. A questionnaire on self-reported skin complaints has recently been developed and validated for use in population surveys, but has not been used until now. Objectives To quantify the skin morbidity in an adult urban population assessed by a newly developed self-measurement instrument, and to explore the associations between skin morbidity and sociodemographic factors in the community. Methods The study was a population-based cross-sectional study carried out in the city of Oslo. Adult participants (n = 18 770) aged 30–76 years answered a questionnaire giving information on self-reported skin complaints, and which included demographic, psychosocial and general health variables. Results Itch was the dominating skin complaint in all age groups. Adjusted odds ratios for itch, self-reported hand eczema and self-reported acne showed significant associations with female gender and reporting households of middle income. There was no association with employment categories. Conclusions This study shows that skin complaints referring to the most common chronic skin diseases varied with age, gender and marital status, and worsened with middle-income household. It provides evidence that household income is associated with skin morbidity, bringing dermatological aspects to studies on health inequalities.
Hepatoma: Tc-99m DISIDA Uptake in Primary and Metastatic Lesions
Authors: FRANK ARCHIBEQUE, MICHAEL R. WILLIAMSON, ROBERT ROSENBERG, BRIAN EISENBERG, MICHAEL DAVIS
Journal: Clinical Nuclear Medicine (1989)

A case is presented in which hepatobiliary imaging with Tc-99m DISIDA of a patient with a primary lesion showed uptake in a metastatic lung lesion but not in the primary tumor.
Cardiovascular Diseases Remain Nation's Leading Cause of Death
Authors: Phil Gunby
Journal: JAMA (1992)

THE SO-CALLED graying of America literally is becoming a heartfelt problem. This is especially true for the nation's women. At a seminar this week in Galveston, Tex, American Heart Association officials cited their own and federal government data indicating that one in nine women aged 45 to 64 years in this country has some form of heart or blood vessel disease. That ratio climbs to one in three women who are aged 65 years or older. <h3>Science Reporters' Forum</h3> These officials used the association's 19th forum for science reporters (<i>JAMA</i>. 1987;258:2197, 2202, 2211) to point out also that—although men have a greater risk of developing hypertension while younger—when persons of either sex reach 55 years of age, the risk of high blood pressure becomes approximately equal. And, says the association, after age 65, women are more likely to develop high blood pressure than men. More than half of all women
Ministers relaunch their payment by results scheme
Authors: Lynn Eaton
Journal: BMJ (2006)

The government has announced plans to reintroduce its ill fated payment by results system for funding health service hospitals in England. It has also increased its funding to three children's hospitals because it fixed payment tariffs for children's treatments too low.

It also intends to “unbundle,” or disaggregate, some of the funding for certain treatments, so that specific elements can be costed separately and provided away from acute hospitals, in the community instead.

The payment by results system, under which providers are paid from a fixed tariff for each individual case treated in NHS hospitals, had to be hastily withdrawn last year because the Department of Health got its sums wrong. It emerged that the calculations …
Oral Thymic Extract To Treat Hepatitis C
Authors: Gary A. Abrams
Journal: Annals of Internal Medicine (1999)

Letters17 August 1999Oral Thymic Extract To Treat Hepatitis CGary A. Abrams, MDGary A. Abrams, MDUniversity of Alabama at Birmingham; Birmingham, AL 35294 (Abrams)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-4-199908170-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Dr. Blank for pointing out the importance in differentiating a qualitative from a quantitative reverse transcription PCR assay. We agree that the latter would be required to support our conclusion that Complete Thymic Formula was ineffective in our cohort. Our manuscript incorrectly stated that the HCV RNA assay performed by National Genetics Institute (NGI) was qualitative; it was actually a quantitative multicycle reverse transcription PCR assay (HCV SuperQuant PCR assay). The NGI qualitative PCR assay reports only the presence or absence of HCV but does not provide a viral titer, as illustrated in Table 1 of ...References1. Tong MJ, Blatt LM, McHutchison JG, Co RL, Conrad A. Prediction of response during interferon Alfa 2b therapy in chronic hepatitis C patients using viral and biochemical characteristics: a comparison. Hepatology. 1997;26:1640-5. CrossrefMedlineGoogle Scholar2. Keefe EB, Hollinger FB. Therapy of hepatitis C: consensus of interferon trials. Consensus Interferon Study Group. Hepatology. 1997;26 Suppl 1 101S-7S. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Alabama at Birmingham; Birmingham, AL 35294 (Abrams) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOral Thymic Extract for Chronic Hepatitis C in Patients Previously Treated with Interferon Robert S. Raymond , Michael B. Fallon , and Gary A. Abrams Oral Thymic Extract To Treat Hepatitis C Robert D. Blank Oral Thymic Extract To Treat Hepatitis C J. L. Frossard Metrics 17 August 1999Volume 131, Issue 4Page: 312KeywordsDrug administrationFoodFood and Drug AdministrationForecastingGeneticsHepatitis CInterferonsInternetRNAReverse transcription Issue Published: 17 August 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Pediatric Oncologic Radiology
Authors: Lawrence A. Davis
Journal: JAMA (1978)

This volume, a multiauthored compendium on oncology in children, meets a need fulfilled until the present only by review articles scattered in the radiological literature. The material (with an excellent preliminary overview by J. A. Wilbur) is divided into two sections, the first dealing with special radiological procedures in childhood and the second concerned with specific childhood tumors. The chapters on angiography, nuclear medicine, and echography are excellent. Unfortunately, and presumably due to publishing time factors, only passing reference to computerized tomography scanning is available. This is unfortunate since computerized tomography scanning is a necessity in evaluation of children for possible brain tumors. The heart of the book is the section on tumors. Particularly informative are the chapters by the editors on Hodgkin's disease and non-Hodgkin's lymphoma. Also filling a vacuum are the well-organized chapters on liver tumors and rhabdomyosarcomas. The rapid and successful development of diagnosis and therapy in
Homocysteine Increases Nitric Oxide Synthesis in Cytokine-Stimulated Vascular Smooth Muscle Cells
Authors: Uichi Ikeda, Michiyo Ikeda, Seiji Minota, Kazuyuki Shimada
Journal: Circulation (1999)

Background —Elevated plasma homocysteine levels have been reported to be an independent risk factor for vascular disease. However, there have been no reports concerning the effects of homocysteine on the production of nitric oxide (NO), another modulator of vascular function and proliferation, by the vascular smooth muscle. Methods and Results —We investigated the effects of homocysteine on NO synthesis by measuring the production of nitrite, a stable metabolite of NO, in cultured rat vascular smooth muscle cells (VSMCs). Incubation of cultures with interleukin (IL)-1β 10 ng/mL for 24 hours caused a significant increase in nitrite generation. The IL-1β–induced nitrite production by VSMCs was significantly increased by homocysteine in a dose-dependent manner. This effect of homocysteine was significantly inhibited in the presence of N G -monomethyl- l -arginine or actinomycin D. The homocysteine-induced nitrite production was accompanied by increased inducible NO synthase mRNA and protein accumulation. Cysteine, glutathione, or hydrogen peroxide also increased nitrite accumulation in IL-1β–stimulated VSMCs. Coincubation with the radical scavenger catalase or superoxide dismutase markedly reduced homocysteine-induced nitrite accumulation. Conclusions —Homocysteine enhances NO synthesis in IL-1β–stimulated VSMCs, and oxidative products are involved in the effect of homocysteine.
Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach
Authors: Marcia Irene Canto, Michael Goggins, Charles J. Yeo, Constance Griffin, Jennifer E. Axilbund, Kieran Brune, Syed Z. Ali, Sanjay Jagannath, Gloria M. Petersen, Elliot K. Fishman, Steven Piantadosi, Francis M. Giardiello, Ralph H. Hruban
Journal: Clinical Gastroenterology and Hepatology (2004)
Association of transforming growth factor-beta (TGF-β) T869C (Leu 10Pro) gene polymorphisms with type 2 diabetic nephropathy in Chinese
Authors: Teresa Yuk Hwa Wong, Peter Poon, Kai Ming Chow, Cheuk Chun Szeto, Man Kuen Cheung, Philip Kam Tao Li
Journal: Kidney International (2003)