Nodular Pneumonitis after Chemotherapy for Germ Cell Tumors
Authors: Donald L. Trump
Journal: Annals of Internal Medicine (1988)

Brief Reports1 September 1988Nodular Pneumonitis after Chemotherapy for Germ Cell TumorsDonald L. Trump, MD, Eric Bartel, BS, Myron Pozniak, MDDonald L. Trump, MDSearch for more papers by this author, Eric Bartel, BSSearch for more papers by this author, Myron Pozniak, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-5-431 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCisplatin-bleomycin-based combination chemotherapy is curative for patients with extensive metastatic germ cell cancer (1, 2). Optimal management of these patients requires repeated serologic and radiographic assessment to monitor regression of disease after chemotherapy. If masses are seen by radiography after chemotherapy and serum markers are normal, surgical removal of these masses is indicated. Surgery will either confirm the eradication of all malignancy by revealing only mature teratoma or necrosis and fibrosis in these masses or reveal residual cancer requiring additional therapy (1, 2). We have noted the appearance of new nodular pulmonary infiltrates by computed tomographic (CT) scan of the...References1. EinhornDonahue LJ. Combination chemotherapy in disseminated testicular cancer: the Indiana University experience. Semin Oncol. 1987;6:87-93. Google Scholar2. EinhornDonahue LJ. Cis-diamminedichloroplatinum, vinblastine and bleomycin combination chemotherapy in disseminated testicular cancer. Ann Intern Med. 1977;87:293-8. LinkGoogle Scholar3. WilliamsBirchEinhornIrwinGrecoLoehrer SRLLFP. Treatment of disseminated germ cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N Engl J Med. 1987;316:1435-40. CrossrefMedlineGoogle Scholar4. PeckhamHorwichBlackmoreHendry MACW. Etoposide and cisplatin with or without bleomycin as first-line chemotherapy for patients with small volume metastases of testicular nonseminoma. Cancer Treat Rep. 1985;69:483-8. MedlineGoogle Scholar5. DeLenaGuzzonMonfardini MAS. Clinical, radiologic and histopathologic studies on pulmonary toxicity induced by treatment with bleomycin. Cancer Treat Rep. 1972;56:343-56. Google Scholar6. BauerSkarinBalikianGarnickRosenthalCanellos KAJMDG. Pulmonary complications associated with combination chemotherapy programs containing bleomycin. Am J Med. 1983;74:557-63. CrossrefMedlineGoogle Scholar7. BellamyHusbandBalquiereLaw EJRM. Bleomycin-related lung damage: CT evidence. Radiology. 1985;156:155-8. CrossrefMedlineGoogle Scholar8. NachmanBaumWhiteCruissi JEHF. Bleomycin-induced pulmonary fibrosis mimicking recurrent metastatic disease in a patient with testicular carcinoma: case report of the CT scan appearance. Cancer. 1981;47:236-9. CrossrefMedlineGoogle Scholar9. McCreaDiaconisWadeJohnston EJJC. Bleomycin toxicity simulating metastatic nodules to the lungs. Cancer. 1981;48:1096-100. CrossrefMedlineGoogle Scholar10. GlasierSiegel CM. Multiple pulmonary nodules: unusual manifestation of bleomycin toxicity. AJR. 1981;137:155-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the University of Wisconsin Clinical Cancer Center, the University of Wisconsin Medical School, and the William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntineoplastic therapy-induced pulmonary toxicityPleuropulmonary Changes Induced by Drugs in Patients with Hematologic DiseasesBleomycin-Induced Pulmonary ToxicityNodular Pneumonitis after Cancer ChemotherapyJames A. Talcott, MD, Marc B. Garnick, MD, Paul C. Stomper, MD, John J. Godleski, MD, Jerome P. Richie, MD 1 September 1988Volume 109, Issue 5Page: 431-432KeywordsChemotherapyCombination chemotherapyComputed axial tomographyDiagnostic radiologyFibrosisGerm cell cancerGerm cellsNecrosisPneumonitisSurgery Issue Published: 1 September 1988 PDF downloadLoading ...