Nephrotic State as the Chief Manifestation of Systemic Lupus Erythematosus
Authors: HIROSHI YAMAUCHI
Journal: Annals of Internal Medicine (1962)

Article1 December 1962Nephrotic State as the Chief Manifestation of Systemic Lupus ErythematosusHIROSHI YAMAUCHI, PIERCE ROONEY, M.D., JAMES HOPPER JR., M.D.HIROSHI YAMAUCHISearch for more papers by this author, PIERCE ROONEY, M.D.Search for more papers by this author, JAMES HOPPER JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-6-981 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe nephrotic syndrome as the chief manifestation of systemic lupus erythematosus (SLE) is rare (1-3). The present report describes the course of illness in 2 patients who were thought to have a nephrotic state with most of the features of "pure nephrosis" (4, 5). In neither case was the presence of systemic lupus erythematosus suspected while the patients were still alive; the diagnosis was established by post-mortem examination.CASE REPORTSCASE 1The patient, an 18-year-old Negro boy, was first seen in the outpatient clinic at the University of California Medical Center in February 1958, because of orchido-epididymitis, for which...References1. BRENNERLEFFHOCHSTEIN JJWAE: Lupus erythematosus disseminatus sine lupo with nephrotic syndrome. Amer. J. Med. 5: 288, 1948. CrossrefMedlineGoogle Scholar2. DUBOIS EL: Effect of L. E. cell test on clinical picture of systemic lupus erythematosus. Ann. Intern. Med. 38: 1265, 1953. LinkGoogle Scholar3. MUEHRCKEKARKPIRANIPOLLAK RCRMCLVE: Lupus nephritis: clinical and pathologic study based on renal biopsies. Medicine (Balt.) 36: 1, 1957. MedlineGoogle Scholar4. HOPPERFARQUHARYAMAUCHIMOONPAGE JMGHHDEW: Renal lesions in pregnancy: clinical observations and light and electron microscopic findings. Obstet. Gynec. (N. Y.) 17: 271, 1961. Google Scholar5. YAMAUCHIHOPPER HJ: Pure nephrosis in adult patient: serial observations of blood volume, serum electrolytes, and renal function. Ann. Intern. Med. 55: 464, 1961. LinkGoogle Scholar6. LUSTEDMORTIMOREHOPPER LBGEJ: Needle renal biopsy under image amplifier control. Amer. J. Roentgenol. 75: 953, 1956. Google Scholar7. FARNSWORTH EB: Metabolic changes associated with administration of adrenocorticotropin in nephrotic syndrome. Proc. Soc. Exp. Biol. Med. 74: 60, 1950. CrossrefMedlineGoogle Scholar8. GOODMANBAXTER HCJH: Nephrotic syndrome: clinical observations on therapy with prednisone and other steroids. JAMA 165: 1798, 1957. CrossrefMedlineGoogle Scholar9. LANGESTRANGSLOBODYWENK KRLBEJ: Treatment of nephrotic syndrome with steroids in children and adults. Arch. Intern. Med. 99: 760, 1957. CrossrefGoogle Scholar10. LANGEWASSERMANSLOBODY KELB: Prolonged intermittent steroid therapy for nephrosis in children and adults. JAMA 168: 377, 1958. CrossrefMedlineGoogle Scholar11. LUETSCHERPIELCURTIS JACFRH: Nephrotic syndrome. J. Chron. Dis. 1: 442, 1955. CrossrefMedlineGoogle Scholar12. METCOFFRANCEKELSEYNAKASONEJANEWAY JCPWMNCA: Adrenocorticotrophic hormone (ACTH) therapy of nephrotic syndrome in children. Pediatrics 10: 543, 1952. MedlineGoogle Scholar13. RAPOPORTMCCRORYSOHN MWWW: Adrenal steroid therapy of nephrotic syndrome: an analysis of treatment results in seventy children. Amer. J. Dis. Child. 90: 631, 1955. Google Scholar14. LANGESLOBODYSTRANG KLR: Prolonged intermittent ACTH and cortisone therapy in nephrotic syndrome; immunologic basis and results. Pediatrics 15: 156, 1955. MedlineGoogle Scholar15. RILEYDAVISFERTIGBERGER CMRAJWAP: Nephrosis of childhood: statistical evaluation of effect of adrenocortical-active therapy. J. Chron. Dis. 3: 640, 1956. CrossrefMedlineGoogle Scholar16. ROSCOE MH: Nephrotic syndrome. Quart. J. Med. 25: 353, 1956. MedlineGoogle Scholar17. JOHNSONREADER JRR: Prognosis in nephrotic syndrome: study with particular reference to adult and older child. Aust. Ann. Med. 8: 200, 1959. MedlineGoogle Scholar18. MAXWELLADAMSBERNSTEINKLEEMANGOLDMAN MHDADCRR: Prolonged corticosteroid therapy in adults with nephrotic syndrome of varying etiology. Clin. Res. 9: 106, 1961. Google Scholar19. HARVEYSHULMANTUMULTYCONLEYSCHOENRICH AMLEPACLEH: Systemic lupus erythematosus: review of literature and clinical analysis of 138 cases. Medicine (Balt.) 33: 291, 1954. CrossrefMedlineGoogle Scholar20. POLLAKPIRANIKARK VECLRM: Effect of large doses of prednisone on renal lesions and life span of patients with lupus glomerulonephritis. J. Lab. Clin. Med. 57: 495, 1961. MedlineGoogle Scholar21. KARKMUEHRCKEPOLLAKPIRANIKIEFER RMRCVECLJH: Analysis of five hundred percutaneous renal biopsies. Arch. Intern. Med. 101: 439, 1958. CrossrefGoogle Scholar22. BRUNRAASCHOU CF: Kidney biopsies. Amer. J. Med. 24: 676, 1958. CrossrefMedlineGoogle Scholar23. ALLEN AC: The Kidney, Medical and Surgical Diseases, Grune & Stratton, Inc., New York, 1951. Google Scholar24. KLEMPERERPOLLACKBAEHR PADG: Pathology of disseminated lupus erythematosus. Arch. Path. 32: 569, 1941. Google Scholar25. POLLAKPIRANIKARKMUEHRCKEFREDANETTLES VECLRMRCVCJB: Reversible glomerular lesions in toxaemia of pregnancy. Lancet 2: 59, 1956. CrossrefGoogle Scholar26. POLLAKKARKPIRANISHAFTERMUEHRCKE VERMCLHARC: Renal vein thrombosis and nephrotic syndrome. Amer. J. Med. 21: 496, 1956. CrossrefMedlineGoogle Scholar27. ARMAS-CRUZHARNECKERDUCACHJALILGONZALEZ RJGJF: Clinical diagnosis of systemic lupus erythematosus. Amer. J. Med. 25: 409, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, CaliforniaFrom the Departments of Medicine and Pathology, University of California School of Medicine.The opinions expressed are solely those of the authors and in no way reflect the official views of the United States Air Force.Requests for reprints should be addressed to the Editorial Office, Department of Medicine, University of California Medical Center, San Francisco 22, California. 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WEINBERGER, M.D., F.A.C.P.Normocholesterolemic nephrotic syndrome of systemic lupus erythematosus 1 December 1962Volume 57, Issue 6Page: 981-987KeywordsAutopsyGlucocorticoid therapyLupus erythematosusOutpatient clinicsVasculitis Issue Published: 1 December 1962 PDF downloadLoading ...