tbuckley/cabot-search huggingface dataset:
Auditory P300 event related potentials and serotonin reuptake inhibitor treatment in patients with fibromyalgia
Authors: S Ozgocmen
Journal: Annals of the Rheumatic Diseases (2003)

The P300 components of auditory event related potentials (ERPs) are objective measures related to information and cognitive processing.To assess P300 ERPs in female patients with fibromyalgia (FM) in comparison with healthy age matched controls. To investigate the relationship between P300 potentials and pain threshold levels of patients, and subsequent effect of sertraline treatment on P300 potentials.P300 auditory ERPs were studied in 13 untreated female patients with FM and 10 healthy controls matched for age, sex, and education. Pain pressure thresholds and total myalgic scores (TMS) were assessed with an algometer. Patients were evaluated for clinical measures and P300 potentials (recorded from the vertex) at the first visit, and then in the fourth and eighth weeks of sertraline treatment.Patients with FM had significantly lower P300 amplitudes, but not significantly different P300 latencies, than controls at entry. P300 latencies in patients correlated negatively with TMS (r(s)=-0.79, p<0.01) and P300 amplitudes correlated significantly with TMS (r(s)=0.53, p<0.05). Anxiety and depression scores did not correlate significantly with P300 latencies or amplitudes at the study entry. P300 auditory ERPs had increased amplitudes that had reached nearly the same levels as those of the controls at the eighth week without any significant change in their latencies.The results show reduced P300 amplitudes in patients with FM. Further studies assessing the relationship between P300 ERPs and neuropsychiatric tests are required for better clarification of the clinical relevance of P300 potentials in FM.
PSYCHOPATHOLOGY AND DISSOCIATION
Authors: W. Brown
Journal: BMJ (1920)

OBJECTIVES: It was reported previously that topside oven workers with heavy exposure to coke oven emissions had increased serum activities of hepatic aminotransferase in one coke oven plant. This study was conducted to investigate the modifying effect of CYP1A1 MspI polymorphism on liver function profiles in coke oven workers. METHODS: 88 coke oven workers from a large steel company in Taiwan were studied in 1995-6. Exposure was categorised by work area: topside oven workers and sideoven workers. Liver function profiles including serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), r-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and total bilirubin (BIL) were examined in the morning after personal exposure measurements. The MspI polymorphism was determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). RESULTS: Five of 23 (22%) topside oven workers and seven of 65 (11%) sideoven workers had the CYP1A1 MspI homozygous variant genotype. With sideoven workers with the combined wild type and heterozygous variant as the reference group in multiple regression models, it was found that topside oven workers with the combined traits had mean AST and ALT activities that were 21% and 46% higher (95% confidence interval (95% CI) 4% to 42% and 12% to 91%, respectively) than the reference group after adjusting for appropriate confounders. Also, topside oven workers with the homozygous variant trait had mean AST, ALT, and GGT activities that were 59%, 68%, and 157% higher (95% CI 21% to 109%, 6% to 168%, and 39% to 374%, respectively) than the reference group. The prevalence of an abnormal hepatocellular pattern (AST &gt; 37 IU/l or ALT &gt; 39 IU/l) was more common in the topside oven workers with the homozygous variant than in the sideoven workers with the other combined genotypes (adjusted odds ratio 9.9, 95% CI 1.2 to 82.3) after adjusting for appropriate confounders. CONCLUSIONS: The CYP1A1 MspI polymorphism may modify the biotransformation of coke oven emissions, which results in hepatocellular damage in coke oven workers.
Bilateral Accessory Iliac Horns
Authors: ELINOR GOSHEN, ARNON SCHWARTZ, LISA RAVIV ZILKA, S. TZILA ZWAS
Journal: Clinical Nuclear Medicine (2000)

Nail-patella syndrome is a rare hereditary (autosomal dominant) disorder, also called hereditary osteo-onychodysplasia and Fong's syndrome. Its incidence is 4.5 per million population in the United States. Patients have a characteristic tetrad of pathologic symptoms including fingernail dysplasia, hypoplastic or absent patellas, radial head dislocation, and iliac horns. Soft-tissue changes and renal dysplasia have also been associated with the syndrome. Iliac horns are bilateral accessory outgrowths consisting of cortex and medulla continuous with the iliac bone. They are located at the site of attachment of the gluteus medius muscles and project posterolaterally. These smooth bony outgrowths are asymptomatic, frequently palpable, and, because they have no effect on gait, they need not be treated. Iliac horns are the pathognomonic feature of Nail-patella syndrome; that is, they occur in approximately 80% of cases and are observed only in this condition. Four patients (two female, two male) with Nail-patella syndrome have been examined in the authors' department: three family members, including a 37-year-old woman, her 18-year-old son, and her 15-year-old daughter, and an unrelated 26-year-old man. All patients, regardless of age or sex, had similar pelvic findings on their bone scans. Although whole-body scans were obtained in all patients, significant scintigraphic findings were observed only in the pelvis in all the patients examined. This is most likely the result of the mild nature of the related deformities, which do not yield scintigraphically detectable osteoblastic changes. A representative image showing these independent ossification on a Tc-99m MDP bone scan is presented. A conventional pelvic radiographic image of the same patient's pelvis is presented for comparison.
Pre/Postbronchodilator Interrupter Resistance Values in Healthy Young Children
Authors: Nicole Beydon, Francis Amsallem, Michèle Bellet, Michèle Boule, Michèle Chaussain, André Denjean, Régis Matran, Bernard Wuyam, Corinne Alberti, Claude Gaultier
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

The interrupter technique estimates flow resistance. It entails occlusion of the airways during tidal breathing while flow and mouth pressure are recorded. This noninvasive technique is easy to use in young children. The aim of the present study was to measure inspiratory and expiratory interrupter resistance (Rintinsp, Rintexp) before and after bronchodilator administration in young healthy white children. We designed a multicenter study using a standardized procedure for Rint measurements. Centers in five French cities studied 91 children (48 boys and 43 girls; height, 92 to 129 cm; mean age 5.3 ± 1.4 years). Mean values were not significantly different for Rintinsp and Rintexp (0.78 ± 0.21 versus 0.78 ± 0.20 KPa · L−1 · second). However, the difference between Rintinsp and Rintexp decreased significantly with age and being positive before 5 years and negative later on (p < 0.02). Rintinsp and Rintexp decreased significantly with height (Rintinsp [KPa · L−1 · second] = 2.289 − 1.37 . 10−2 · H [cm], Rintexp [KPa · L−1 · second] = 2.021 − 1.12.10−2 · H [cm]; p < 0.001). Bronchodilator (salbutamol) administration significantly decreased Rintinsp and Rintexp (p < 0.001). Bronchodilator-induced changes (% of predicted values) in mean Rintinsp and mean Rintexp were −15% (95% confidence interval, −46 to +15%) and −12% (95% confidence interval, −46 to +22%), respectively. Sex did not affect pre- or postbronchodilator values. Data from the present study may prove useful for testing lung function in young children with respiratory disorders who failed to cooperate with forced expiratory maneuvers.
Regular prescribing in a residential home for elderly women.
Authors: S A Bruce
Journal: BMJ (1982)

At the start of the study the 20 patients had been taking a total of 52 preparations (average 2 6, range 0-6 (2 patients receiving 0), com? prising 62 drugs (average 3 1) for longer than three months. These are classified in table I according to the British National Formulary 1981, No 1. Thirty-one preparations had been prescribed for more than a year, nine for more than 5 years, and four for more than 10 years. Seventeen preparations had been started by a principal, 18 by a trainee, and 17 after a hospital encounter. The total number of drug doses given in the home (including occasional prescriptions and those for the remaining 10 patients) is regularly about 200 per day. Only 13 (25%) of the regular prescriptions were unequivocally justified and in no need of change, while nearly 20% were no longer necessary (table II). Half of the 38% of prescriptions for drugs affecting the central nervous system were stopped. None had to be restarted. In a woman with severe side effects from anti-Parkinsonian drugs and in whom there were no symptoms or signs of Parkinson's disease three months after their complete withdrawal the benefit was so obvious
Transparency in the Delivery of Mental Health Care—Reply
Authors: Jan Walker, Michael W. Kahn, Tom Delbanco
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immediate and Remote Results of Chloroethylamine Treatment of Hodgkin's Disease
Authors: L. F. Larionov
Journal: BMJ (1956)

PUERPERAL FEVER BREICSH we allow mothers to be infected.For all these reasons we cannot afford to let up in our aseptic and antiseptic pre- cautions.And we should perhaps remember that large parts of the world have not yet achieved the high standard of obstetric practice that now obtains in the most progressive countries.In those less fortunate countries unskilled midwifery will still take its heavv toll.
Leszek Stanislaw Galazka
Authors: Dermot Lynch
Journal: BMJ (2006)

Organization Dr Lee Jong-wook continued the revival of the agency begun by his predecessor, Gro Harlem Brundtland.Having taken over from the formidable Norwegian in 2003, Dr Lee continued to push health to the top of the global political agenda, winning plaudits for his style, which was based on action not words.He entered office as the threat of severe acute respiratory syndrome was subsiding, and it was bird flu-a pandemic that has yet to emerge-that was to dominate much of his time as leader of WHO.However, in the long term it is likely to be his bold, if ultimately unattainable, pledges on HIV treatment that will be remembered.Apart from his expertise in public health Dr Lee was a consummate politician-a characteristic that raised a few eyebrows at the time of his candidature.A number of health experts remarked that Dr Lee had acted more like a politician than a scientist in his extensive lobbying for the top job.As part of his strategy to get elected he persuaded more than 50 members of the US Congress to write to the US government backing his candidacy.He also remarked in an interview later that year that "you can't make it to this position without being a politician."Conversely, some commentators thought that this poor public speaker with a modest demeanour would be out of his depth on the world stage.But he was soon able to build personal contacts with George Bush, Jacques Chirac, and China's president, Hu Jintao.This July he had been due to address the G8 summit in St Petersburg at the personal invitation of Vladimir Putin.Dr Lee understood that the steps he had publicly avowed he would take against infectious diseases and tobacco related illnessfrom which his father had died-would not be possible without the support of world leaders.He declared that tuberculosis, polio, malaria, and above all, AIDS, would be key battlegrounds during his leadership.He introduced the "3 by 5" campaign, in which WHO pledged that three million HIV patients-most of whom were in the developing world-would have access to
Pseudotumor of the Omentum Presenting as a Surgical Emergency
Authors: Brian D. Blackbourne
Journal: JAMA (1965)

THE CASE to be reported concerns a nonneoplastic tumor of the omentum which we have designated as a pseudotumor (benign pseudoneoplasm); Ackerman's 1 classification of omental tumors does not refer to this type of tumor.  Report of a Case  History.—  A 28-year-old Negro university student was admitted to the Cottage Hospital on June 4, 1964, giving a 24-hour history of abdominal pain localizing in the right lower quadrant. This was associated with nausea and vomiting. He had a somewhat similar episode three months previously which had subsided spontaneously in 48 hours. His only previous illness was prostatitis in 1960.  Physical Examination.—  The patient's temperature was 99.4 F (37 C); abdominal tenderness was most marked over McBurney's point. Guarding and rebound were present in the same area.  Laboratory Studies.—  White blood cell count was 11,900/ cu mm with 1% young neutrophils, 84% segmented neutrophils, 9% lymphocytes, and 6% monocytes. Urine was
Functional Haplotypes in the Promoter of Matrix Metalloproteinase-2 Predict Risk of the Occurrence and Metastasis of Esophageal Cancer
Authors: Chunyuan Yu, Yifeng Zhou, Xiaoping Miao, Ping Xiong, Wen Tan, Dongxin Lin
Journal: Cancer Research (2004)

Abstract Matrix metalloproteinase-2 (MMP-2) plays important roles in cancer development and aggression. Our previous studies revealed a strong association between the MMP-2 −1306C/T polymorphism and risk of several cancers. A novel −735C/T polymorphism in MMP-2 promoter has been identified but the function is undefined. This study examined our hypothesis that these two polymorphisms might have functional relevance and impact on risk of esophageal squamous cell carcinoma in the context of haplotype. Genotypes and haplotypes were analyzed in 527 cases and 777 controls and odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression. The function of the polymorphisms was examined by electrophoretic mobility shift assays, luciferase gene expression assays, and reverse transcriptase-PCR analyses. It was found that the −735C→T transition disrupts an Sp1 site and displays a lower promoter activity. The C-1306–C-735 haplotype had 7-fold increased luciferase expression and 3.7-fold increased MMP-2 mRNA levels in esophageal tissues compared with the T-1306–T-735 haplotype. A case-control analysis revealed a 1.52-fold (95% CI = 1.17–1.96) or 1.30-fold (95% CI = 1.04–1.63) excess risk of developing esophageal squamous cell carcinoma for the −1306CC or −735CC genotype carriers compared with noncarriers, respectively. A greater association was observed between elevated risk of developing esophageal squamous cell carcinoma and C-1306 or C-735 allele containing haplotypes, with the risk being highest for the C-1306–C-735 haplotype compared with the T-1306–T-735 haplotype (OR = 6.53; 95% CI = 2.78–15.33). The C-1306–C-735 haplotype was also associated with increased risk for distant metastasis of esophageal squamous cell carcinoma (OR = 3.34; 95% CI = 1.16–9.63). These findings suggest that the C-1306–C-735 haplotype in the MMP-2 promoter contributes to risk of the occurrence and metastasis of esophageal squamous cell carcinoma by increasing expression of MMP-2.
Cerebral Infarction Pattern Identified on Emission Computed Tomography Using Technetium-99m MDP
Authors: JOSEPH C. WALLACE, DONALD BEYEA
Journal: Clinical Nuclear Medicine (1988)

In the metastatic work-up of a patient with a malignant lung tumor and cerebrovascuiar disease, bone imaging was performed which showed abnormal uptake in the right parietal region. Emission computed tomography indicated that this was due to intracranial disease and revealed a wedge-shaped pattern indicative of cerebral infarction. A later follow-up study showed complete clearance of the abnormal uptake.
Allopurinol (Xanthine Oxidase Inhibitor) in the Treatment of Resistant Gout
Authors: Elmer C. Bartels
Journal: JAMA (1966)

Allopurinol was given to 24 patients with gout resistant or intolerant to uricosuric drugs; in each case a substantial fall in serum uric acid level resulted. There was a sensitive relationship between the dose of allopurinol and the level of serum uric acid. There was no relationship between the severity of gout or degree of renal disease and the dose of allopurinol required to maintain a satisfactory level of serum uric acid. Response to treatment was satisfactory in all patients except one. Benefit was confirmed by adequate control of hyperuricemia, improvement in well-being, relief of joint pain, increase in joint mobility, decrease in joint swelling, subsidence of recurring attacks of gout, decrease in size of tophi, and reossification of bones. Long-term treatment with allopurinol was found feasible and troublesome recurring gout was not a problem. Colchicine was given simultaneously in only one case; a long-term trial with this combination was not carried out. Allopurinol is indicated in patients who have troublesome gout not responsive to treatment.
Expression and role of Bcl-xL in human hepatocellular carcinomas
Authors: Tetsuo Takehara, Xiaolong Liu, Jiro Fujimoto, Scott L. Friedman, Hiroshi Takahashi
Journal: Hepatology (2001)

Transformed hepatocytes survive various apoptotic insults during their growth in vivo . However, molecular mechanisms that inhibit apoptosis and support their survival are not well understood. In this study, we investigated the expression and role of Bcl–xL, an antiapoptotic member of the Bcl–2 family, in human hepatocellular carcinoma (HCC). The Bcl–xL protein was expressed in HepG2, Hep3B, and Huh7 human hepatoma cell lines at high levels, but none of these cells expressed Bcl–2. Down–modulation of Bcl–xL by antisense oligonucleotide activated apoptosis in HepG2 cells in response to cellular stresses induced by staurosporine treatment or by serum starvation. Ectopic expression of transcriptionally active p53 alone was not sufficient for the activation of apoptosis in p53 –null Hep3B cells, but apoptosis was induced when endogenous Bcl–xL was simultaneously inhibited by antisense oligonucleotide in these cells. Bcl–xL was expressed in all 20 surgically resected human HCC tissues when examined by Western blot analysis and immunohistochemistry, and levels of its expression were higher in a subset of HCC tissues than those of adjacent nontumor liver tissues or normal livers. We conclude that Bcl–xL expressed in human HCC cells inhibits apoptosis produced by various cellular stresses, such as staurosporine treatment, serum starvation, and p53 activation, and may play an important role in their survival.
Chronic neutrophilic leukemia associated with polycythemia vera
Authors: G. Lugassy, R. Farhi
Journal: American Journal of Hematology (1989)

Chronic Neutrophilic Leukemia Associated With Polycythemia VeraPolycythemia Vera (PV) often terminates in a picture of myelofibrosis or acute leukemia.Other hematologic malignancies have been more rarely reported in the course of PV [ 11.We report the case of a 61-year-old patient who developed chronic neutrophilic leukemia 15 years after the diagnosis of PV.A 61-year-old female patient was seen at the Hematology Institute of the Ashkelon Hospital in 1973 because of a left leg deep vein thrombosis.The spleen and the liver were enlarged, palpated, respectively, 10 and 8 cm below the costal margin.Hemoglobin was 18.8 g/dl, hematocrit 68%, the white blood cell count 16,800/mm3, platelets 320,000/mm3.Arterial oxygen saturation was 96%.Red blood cell mass was 5 1 ml/kg (normal up to 36 ml/kg).The leukocyte alkaline phosphatase (LAP) score was 82 (normal 50-150) and the serum vitamin B I 2 level was 420 ng/l.A bone marrow biopsy showed hyperplasia of both erythroid and myeloid lines.Chromosome studies of marrow cells revealed a translocation t:9:13 and t:9:16 but no Ph chromosome.The patient was treated with radioactive phosphorus, then with chlorambucil and later with busulfan.For several years the hemoglobin, hematocrit, leukocyte, and platelet counts were kept within normal range.In May 1987, the leukocytes rose to 44,000/mm3, and in September 1987, to 88,000/mm3 with 70% neutrophils, 3% band forms, 2% monocytes, and 25% lymphocytes.Hemoglobin and platelet count were normal.A bone marrow biopsy revealed a very severe myeloid hyperplasia and an active erythropoiesis, with no increase in reticulin.Chromosomal studies showed a translocation from chromosome 11 in all studied marrow cells.LAP score was 200, serum vitamin BI2 1,400 ng/l, and LDH 450 iv/l.From September 1987 until September 1988, therapy with hydroxyurea maintained the leukocyte count at around 20,000/mm3 and the hemoglobin and platelets within normal limits.In September 1988, the enlarged spleen became painful and was palpated 14 cm below the costal margin.The leukocyte count rose to 120,000/mm3 with neutrophils 70%, band forms 3%, metamyelocytes 2%, myelocytes 2%, promyelocytes 1%, blast cells 4%, monocytes 2%, and lymphocytes 18%.The hemoglobin dropped to 10.5 g/dl and the platelets progressively decreased down to
Reviews and Notes: Oncology: Atlas of Diagnostic Oncology
Authors: Paul F. Engstrom
Journal: Annals of Internal Medicine (1996)

Literature of Medicine1 September 1996Reviews and Notes: Oncology: Atlas of Diagnostic OncologyPaul F. Engstrom, MDPaul F. Engstrom, MDFox Chase Cancer Center, Philadelphia, PA 19111Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-5-199609010-00043 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail 2nd edition. AT Skarin; ed. 605 pages. St. Louis: Mosby-Wolfe; 1996. $180.00. ISBN 0723421757. Order phone 800-633-6699.The multidisciplinary clinical pathology conference is a favorite educational forum for medical students, house staff, postdoctoral trainees, and attending physicians. Discussion frequently focuses on an unusual clinical presentation or diagnostically challenging case, and the visual images provided by clinical photographs, pertinent radiographs or scans, and the projected microscopic pathology emphasize a clinical point that will never be forgotten. This time-honored forum lives on in the Atlas of Diagnostic Oncology. In my opinion, this book is the foremost compendium of clinical, radiologic, and microscopic ... Author, Article, and Disclosure InformationAffiliations: Fox Chase Cancer Center, Philadelphia, PA 19111 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1996Volume 125, Issue 5Page: 430KeywordsCancer immunotherapyClinical pathologyHead and neck cancersLymphomaMalignant tumorsMedical educationMesotheliomaPlasma cellsSystemic diseasesTumor node metastasis ePublished: 15 August 2000 Issue Published: 1 September 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...