Pathogenesis and Frequency of Essential Fatty Acid Deficiency During Total Parenteral Nutrition
Authors: WILLIAM E. CONNOR
Journal: Annals of Internal Medicine (1975)

Editorials1 December 1975Pathogenesis and Frequency of Essential Fatty Acid Deficiency During Total Parenteral NutritionWILLIAM E. CONNOR, M.D., F.A.C.P.WILLIAM E. CONNOR, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-6-895 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEssential fatty acid deficiency has heretofore been considered as a rare entity, noted experimentally in the rat and perhaps occurring under unusual circumstances in early infancy but never reported in adult humans. Now the common practice of total parenteral nutrition (intravenous hyperalimentation) in patients unable to take food orally or who have the short bowel syndrome has already led to a number of clinical reports of essential fatty acid deficiency (1-3). Indeed, the current evidence indicates that all patients who receive total parenteral feedings consisting of glucose and amino acids and devoid of linoleic acid (C18:2) would develop the deficiency...References1. COLLINSSINCLAIRROYLE FAJ: Plasma lipids in human linoleic acid deficiency. Nutr Metab 13:150-167, 1971 CrossrefMedlineGoogle Scholar2. RICHARDSONSGOUTAS TD: Essential fatty acid deficiency in four adult patients during total parenteral nutrition. Am J Clin Nutr 28:258-263, 1975 CrossrefMedlineGoogle Scholar3. RIELLABROVIACWELLS MJM: Essential fatty acid deficiency in human adults during total parenteral nutrition. Ann Intern Med 83:786-789, 1975 LinkGoogle Scholar4. WENECONNORDENBESTEN JWL: The development of essential fatty acid deficiency in healthy man fed fat-free diets intravenously and orally. J Clin Invest 56:127-134, 1975 CrossrefMedlineGoogle Scholar5. FREEMANSTEGINKMEYER JLP: Metabolic effects of amino acid vs. dextrose infusion in surgical patients. Arch Surg 110:916-921, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Cardiology Department of Medicine University of Oregon Health Sciences Center Portland, Oregon PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLipids: Functional Effects and Clinical Application inParenteral NutritionThe Use of Fish Oil Lipid Emulsion in the Treatment of Intestinal Failure Associated Liver Disease (IFALD)Fish oil prevents essential fatty acid deficiency and enhances growth: clinical and biochemical implicationsMetabolic and nutritional considerations in nonalcoholic fatty liverStudy of plasma and red cell phospholipid fatty acids in extrahepatic cholestatic jaundice.Essential fatty acids and the skinEffect of Emulsions of Medium and Long Chain Triglyceride on Human Adipose Tissue Prostaglandin Production in VitroEnteral and Parenteral Nutrition in the Elderly PatientNutritional Support of the Geriatric PatientKonservative TherapieEssential Fatty AcidsLow Plasma Cortisol and Hematologic Abnormalities Associated With Essential Fatty Acid Deficiency in ManPeripheral and Total Parenteral NutritionChanges in essential fatty acid profile of serum phospholipids in human diseaseEnteral Nutrition: Frequency of Formula ModificationEffect of Total Parenteral Nutrition with Cycling on Essential Fatty Acid DeficiencySupplemental Nutrition and Digestive DiseaseSerum lipids in total parenteral nutrition (TPN): Effect of fatDie Bedeutung der Essentiellen Fettsäuren für Patienten Mit Einer Akuten, Schweren KrankheitNutritional Therapy of the Urologic PatientIntravenous Fat 1 December 1975Volume 83, Issue 6Page: 895-896KeywordsAdultsAmino acidsFatty acidsFoodGlucosePathogenesisTotal parenteral nutrition Issue Published: 1 December 1975 PDF DownloadLoading ...