tbuckley/cabot-search huggingface dataset:
The combination of complement deficiency and cigarette smoking as risk factor for cutaneous lupus erythematosus in men; a focus on combined C2/C4 deficiency
Authors: P. Boeckler, M. Milea, A. Meyer, B. Uring-Lambert, E. Heid, G. Hauptmann, B. Cribier, D. Lipsker
Journal: British Journal of Dermatology (2005)

Journal Article The combination of complement deficiency and cigarette smoking as risk factor for cutaneous lupus erythematosus in men; a focus on combined C2/C4 deficiency Get access P. Boeckler, P. Boeckler Clinique Dermatologique and Laboratoire d'Immunologie, Hôpitaux Universitaires de Strasbourg, France Search for other works by this author on: Oxford Academic Google Scholar M. Milea, M. Milea Clinique Dermatologique and Laboratoire d'Immunologie, Hôpitaux Universitaires de Strasbourg, France Search for other works by this author on: Oxford Academic Google Scholar A. Meyer, A. Meyer Clinique Dermatologique and Laboratoire d'Immunologie, Hôpitaux Universitaires de Strasbourg, France Search for other works by this author on: Oxford Academic Google Scholar B. Uring‐Lambert, B. Uring‐Lambert Clinique Dermatologique and Laboratoire d'Immunologie, Hôpitaux Universitaires de Strasbourg, France Search for other works by this author on: Oxford Academic Google Scholar E. Heid, E. Heid Clinique Dermatologique and Laboratoire d'Immunologie, Hôpitaux Universitaires de Strasbourg, France Search for other works by this author on: Oxford Academic Google Scholar G. Hauptmann, G. Hauptmann Clinique Dermatologique and Laboratoire d'Immunologie, Hôpitaux Universitaires de Strasbourg, France Search for other works by this author on: Oxford Academic Google Scholar B. Cribier, B. Cribier Clinique Dermatologique and Laboratoire d'Immunologie, Hôpitaux Universitaires de Strasbourg, France Search for other works by this author on: Oxford Academic Google Scholar D. Lipsker D. Lipsker Clinique Dermatologique and Laboratoire d'Immunologie, Hôpitaux Universitaires de Strasbourg, France D. Lipsker, Clinique Dermatologique, 1, Place de l'hôpital, 67091 Strasbourg Cedex, France. E‐mail: dlipsker@noos.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 152, Issue 2, 1 February 2005, Pages 265–270, https://doi.org/10.1111/j.1365-2133.2004.06308.x Published: 01 February 2005 Article history Accepted: 30 May 2004 Published: 01 February 2005
Mammography: A Contrary View
Authors: JOHN C. BAILAR
Journal: Annals of Internal Medicine (1976)

Experimental and clinical data on mammography as a tool for population screening are reviewed. The conclusions are that [1] there is good evidence that annual history, physical examination, and mammography can reduce short-term and midrange breast cancer mortality by about one third; [2] the evidence that mammography alone plays a significant role in this reduction is weak and indirect; [3] data on long-term effects of mammography are lacking; [4] no satisfactory investigations of associated radiation hazards have been published; and [5] the possible benefits of mammography have received more emphasis in the clinical literature than have its defects. Promotion of mammography as a general public health measure is premature.
Salmonellae from Faeces of Domestic Animals
Authors: H. W. Smith, A. Buxton
Journal: BMJ (1951)

A note in Nature, May 5, page 730, draws attention to the unreliability of killing the eggs of worms in faeces with formalin.A faecal specimen from a patient infected with Ascaris lumbricoides was preserved in hot 10% formalin in March, and when the specimen was examined in November many eggs were found containing motile Ascaris larvae.although the formalin concentration was still 6%.
Microenvironmental Independence Associated with Tumor Progression
Authors: Alexander R.A. Anderson, Mohamed Hassanein, Kevin M. Branch, Jenny Lu, Nichole A. Lobdell, Julie Maier, David Basanta, Brandy Weidow, Archana Narasanna, Carlos L. Arteaga, Albert B. Reynolds, Vito Quaranta, Lourdes Estrada, Alissa M. Weaver
Journal: Cancer Research (2009)

Abstract Tumor-microenvironment interactions are increasingly recognized to influence tumor progression. To understand the competitive dynamics of tumor cells in diverse microenvironments, we experimentally parameterized a hybrid discrete-continuum mathematical model with phenotypic trait data from a set of related mammary cell lines with normal, transformed, or tumorigenic properties. Surprisingly, in a resource-rich microenvironment, with few limitations on proliferation or migration, transformed (but not tumorigenic) cells were most successful and outcompeted other cell types in heterogeneous tumor simulations. Conversely, constrained microenvironments with limitations on space and/or growth factors gave a selective advantage to phenotypes derived from tumorigenic cell lines. Analysis of the relative performance of each phenotype in constrained versus unconstrained microenvironments revealed that, although all cell types grew more slowly in resource-constrained microenvironments, the most aggressive cells were least affected by microenvironmental constraints. A game theory model testing the relationship between microenvironment resource availability and competitive cellular dynamics supports the concept that microenvironmental independence is an advantageous cellular trait in resource-limited microenvironments. [Cancer Res 2009;69(22):8797–806]
Stage III Thymic Epithelial Neoplasms are Not Homogeneous with Regard to Clinical, Pathological, and Prognostic Features
Authors: Min-Woong Kang, Eung-Sirk Lee, Jisuk Jo, Joungho Han, Yong Chan Ahn, Hong Kwan Kim, Yong Soo Choi, Kwhanmien Kim, Young Mog Shim, Jhingook Kim
Journal: Journal of Thoracic Oncology (2009)
Book: Textbook of Sports Medicine: Basic Science and Clinical Aspects of Sports Injury and Physical Activity
Authors: D. MacAuley
Journal: BMJ (2003)

Eds Michael Kjaer, Michael Krogsgaard, Peter Magnusson, Lars Engebretsen, Harald Roos, Timo Takala, Savio L-Y Woo Blackwell Science, £89.50, pp 808 ISBN 0 632 06509 5 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> Heaving, pumping, lifting, pushing, sweating, stretching, jumping, sprinting—all are drawn together in the ultimate performance. This book is an exceptional achievement, showing, once again, that the Scandinavians lead the field in academic sports medicine. The authors all come from Nordic countries or have strong links with them. And it shows. Astrand and Rodahl, the first household names in sports science, have worthy successors. … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
<i>Listeria monocytogenes</i>Infection and Its Relation to Infectious Mononucleosis
Authors: Bernard H. Chaiken, Doraine T. Michaud
Journal: New England Journal of Medicine (1958)

LISTERIOSIS is a sporadic infectious disease caused by Listeria monocytogenes, a gram-positive motile bacillus, occurring naturally in rodents and ruminants.1 , 2 In human beings it has caused a severe form of meningitis and a syndrome similar to infectious mononucleosis.2 3 4 In the preantibiotic period, the meningitic form had a mortality of 68 per cent.2 Fortunately, in more recent years, the organism has been found to be sensitive to one or more of the commonly used antibiotics.5 6 7 In the case reported below, listeriosis was successfully treated with chloramphenicol and chlortetracycline, and the patient presented a clinical, hematologic and serologic picture like that of . . .
Prostate Cancer: An Update
Authors: R. P. Huben, G. P. Murphy
Journal: CA A Cancer Journal for Clinicians (1986)

cer deaths.'In 1986, an estimated 90,000 men in the US will be diagnosed with pros tate cancer, and 26,100 deaths from the disease are expected to occur.'Studies sug gest that the incidence of prostate cancer in the US has increased in recent years, partic ularly in black males, while there has been a smaller increase in mortality.2'3The in cidence and mortality of carcinoma of the prostate among blacks in the US are almost twice those for whites.4Despite numerous studies, no causeforthis racial difference has been established.The reported incidence and mortality also vary widely from country to country: Northern European and North American countries have high rates, while Oriental and Eastern European countries have low rates.2'3Although these findings and spo radic reports of a familial occurrence of prostate cancer suggest a genetic predispo sition, there is little current evidence that this is a significant factor in most patients.Age has a major impact on the inci dence of prostate cancer.The disease is uncommon in men younger than age 50, but the incidence increases sharply to more than 1,000 per 100,000 man-years for American males age 85 and over.2The average age of prostate cancer patients at the time of diagnosis is 73 years.4Studies that attempt to correlate this finding with age-related changes in testosterone levels or other endocrine functions have shown no consistent relationship.Benign prostate hyperplasia also increases in incidence with
Stigma and Mental Illness
Authors: Edwin J. Mikkelsen
Journal: JAMA (1993)

The devotion of an entire book to the subject of stigma is indicative of the increasing importance ascribed to the subject, which previously was widely recognized but only rarely formally written about in a thoughtful manner. To grasp its pervasive and powerful force, one only has to remember the withdrawal of proposed vice presidential candidate James Eagleton after the disclosure of prior treatment with electroconvulsive therapy or the more recent negative impact of reports of prior treatment for depression on the presidential candidacy of Michael Dukakis. While the effects on candidates for the highest office in the country are dramatic, perhaps even more sinister are the effects on the large numbers of citizens who are routinely discriminated against in the workplace and throughout society because of a history of emotional illness. Thus, it is appropriate that a book be devoted to a thorough discussion of the many issues related to
Red Cross steps up activity in Pakistan and Afghanistan to deal with increase in casualties
Authors: J. Zarocostas
Journal: BMJ (2009)

The International Committee of the Red Cross says it is increasing its activities in Pakistan and Afghanistan because of the anticipated swell in numbers of civilian casualties in ongoing armed conflicts in the countries.

“We expect civilians to bear the brunt of the conflicts,” said Jacques de Mayo, the committee’s head of operations for South Asia. “We expect more war wounded, more civilians being displaced.”

In 2008 the Red Cross assisted 40 000 internally displaced …
Percutaneous Treatment of Protected and Unprotected Left Main Coronary Stenoses With New Devices: Immediate Angiographic Results and Intermediate-Term Follow-Up
Authors: John J Lopez, Kalon K.L Ho, Robert C Stoler, Ronald P Caputo, Joseph P Carrozza, Richard E Kuntz, Donald S Baim, David J Cohen
Journal: Journal of the American College of Cardiology (1997)

Objectives. We sought to evaluate the immediate angiographic results and intermediate-term follow-up after percutaneous treatment of left main coronary stenoses in the new device era. Background. Historically, balloon angioplasty of left main coronary stenoses has been associated with high procedural morbidity and poor long-term results. It is not clear whether new devices are more effective in this anatomic setting. Methods. Between July 1993 and July 1995, we performed initial left main coronary interventions on 46 patients (mean age 67 ± 12 years, 26% women). Quantitative angiography was available for 42 of 46 interventions, and clinical follow-up was obtained for all patients at 1 month, 6 months and 1 year after initial revascularization. Results. Most interventions (42 of 46) were performed in patients with "protected" coronary stenoses to the left coronary system owing to the presence of one or more patent left main coronary grafts. Seventy-seven percent of screened patients were deemed unsuitable for repeat coronary artery bypass surgery. Procedures performed included stenting in 73% of patients (alone in 30% and after rotational atherectomy in 43%), rotational atherectomy in 58% (alone in 15% and before stenting in 43%), directional atherectomy in 4% and angioplasty alone in 7%. Initial procedural success was achieved in all interventions, with no deaths, myocardial infarctions (creatine kinase, MB fraction >50 IU/liter) or emergent bypass surgery. Follow-up data to date (median duration 9 months, range 6 to 19) demonstrate a 98% overall survival rate and a 6-month event-free survival rate of 78% (six target vessel revascularizations [TVRs], four non-TVRs). Conclusions. Treatment of protected left main coronary artery stenoses can be accomplished safely and effectively with new device technology. Intermediate-term follow-up demonstrates an acceptably low rate of death, myocardial infarction or repeat revascularization at 6 months and 1 year. (J Am Coll Cardiol 1997;29:345–52)
Hemodynamic Responses to Tilt and Beta-Adrenergic Blockade in Young Patients with Borderline Hypertension
Authors: RUNE SANNERSTEDT, STEVO JULIUS, JAMES CONWAY
Journal: Circulation (1970)

Seventeen young patients with borderline hypertension (one female) and 18 normotensive paid volunteers (two females) were studied at rest and in the tilted position after 10 min of 45° head-up tilt. Cardiac output, heart rate, and intra-arterial pressure were recorded. The measurements at rest and during the tilt were repeated after betaadrenergic blockade with propranolol. By comparison with the normotensives, cardiac output and heart rate in those with borderline hypertension were elevated initially, after 50 min of rest, and during tilt. The change of the cardiac output and heart rate to tilt was of the same magnitude in patients and control subjects. Consequently, regulation of the rate and flow in borderline hypertensives appears to be normal but starts from a higher base line level. After blockade with propranolol, cardiac output in patients with borderline hypertension was still slightly elevated, but the difference from controls was not significant. The heart rate, however, remained significantly elevated at rest and during tilt. Elevation of the heart rate in borderline hypertensives is not mediated through the beta-adrenergic system and may result from decreased parasympathetic inhibition or from different intrinsic myocardial pacing.
Supervision of Mental Defectives
Authors: J. S. Cookson
Journal: BMJ (1945)

Deputy County Medical Officer of Gloucestershire The object of this communication is to place on record the changes which wartirmie has brought to those mental defectives who live in the community.This study is limited to those persons ascertained as mental defectives under the Mental Deficiency Acts (1913 and 1927) and therefore under the supervision of the local authority.This supervision was undertaken primarily to provide an immediate remedy where the defective was being cruelly treated or had been left without adequate protection, and also afforded an opportunity to give warning and assistance to the relatives where such were found necessary.The name of the ascertained mental defective is recorded in the National Register as a person not subject to the National Services (Armed Forces) Act, 1939; he is thus able to seek employment on his own without reference to the employment exchange.As a result of shortage of man-power some of those who before the war would have been looked upon as unemployable are now in full work.To my knowledge no similar investigation has been recorded in the English literature, but Kannar (1942) has drawn attention to the comparable position in the United States of America. Statutory SupervisionAt the beginning of 1944 there were 323 ascertained mental defectives in Gloucestershire subject to supervision by health visitors.This total may be divided for the sake of convenience into three main groups, and it is the third group with which these notes are mainly concerned.(a) Unsuitable for School (96 Cases).-Theseare the youngest cases under statutory supervision, and include children below school age and children of school age who are uneducable either at an TABLE I.
Neuromodulators Control the Polarity of Spike-Timing-Dependent Synaptic Plasticity
Authors: Geun Hee Seol, Jokubas Ziburkus, ShiYong Huang, Lihua Song, In Tae Kim, Kogo Takamiya, Richard L. Huganir, Hey-Kyoung Lee, Alfredo Kirkwood
Journal: Neuron (2007)
Myocardial Free Fatty Acid and Glucose Use After Carvedilol Treatment in Patients With Congestive Heart Failure
Authors: Thomas R. Wallhaus, Michael Taylor, Timothy R. DeGrado, Douglas C. Russell, Peter Stanko, Robert J. Nickles, Charles K. Stone
Journal: Circulation (2001)

Background —Use of β-adrenoreceptor blockade in the treatment of heart failure has been associated with a reduction in myocardial oxygen consumption and an improvement in myocardial energy efficiency. One potential mechanism for this beneficial effect is a shift in myocardial substrate use from increased free fatty acid (FFA) oxidation to increased glucose oxidation. Methods and Results —We studied the effect of carvedilol therapy on myocardial FFA and glucose use in 9 patients with stable New York Heart Association functional class III ischemic cardiomyopathy (left ventricular ejection fraction ≤35%) using myocardial positron emission tomography studies and resting echocardiograms before and 3 months after carvedilol treatment. Myocardial uptake of the novel long chain fatty acid metabolic tracer 14(R, S)-[ 18 F]fluoro-6-thia-heptadecanoic acid ([ 18 F]-FTHA) was used to determine myocardial FFA use, and [ 18 F]fluoro-2-deoxy-glucose ([ 18 F]-FDG) was used to determine myocardial glucose use. After carvedilol treatment, the mean myocardial uptake rate for [ 18 F]-FTHA decreased (from 20.4±8.6 to 9.7±2.3 mL · 100 g –1 · min –1 ; P &lt;0.005), mean fatty acid use decreased (from 19.3±7.0 to 8.2±1.8 μmoL · 100 g –1 · min –1 ; P &lt;0.005), the mean myocardial uptake rate for [ 18 F]-FDG was unchanged (from 1.4±0.4 to 2.4±0.8 mL · 100 g –1 · min –1 ; P =0.14), and mean glucose use was unchanged (from 11.1±3.1 to 18.7±6.0 μmoL · 100 g –1 · min –1 ; P =0.12). Serum FFA and glucose concentrations were unchanged, and mean left ventricular ejection fraction improved (from 26±2% to 37±4%; P &lt;0.05). Conclusions —Carvedilol treatment in patients with heart failure results in a 57% decrease in myocardial FFA use without a significant change in glucose use. These metabolic changes could contribute to the observed improvements in energy efficiency seen in patients with heart failure.
1078-99 Monocyte chemoattractant protein-1 induced monocyte infiltration and angiogenesis does not result in arteriogenesis or improved cardiac function in chronically infarcted myocardium
Authors: Ernst R Schwarz, Dennis A Meven, Philipp H Kersting, Tanja Tussing, Erik C Skobel, Peter Hanrath
Journal: Journal of the American College of Cardiology (2004)
Comparison of the defibrillation threshold and the upper limit of ventricular vulnerability.
Authors: P S Chen, N Shibata, E G Dixon, R O Martin, R E Ideker
Journal: Circulation (1986)

To examine the relationship between the defibrillation threshold and the strength of shocks that induce ventricular fibrillation during the vulnerable period, we determined the defibrillation threshold in 22 open-chest dogs using epicardial defibrillation electrodes with the cathode at the ventricular apex and the anode at the right atrium. We also determined whether there was an upper limit of shock strength that induces fibrillation in the vulnerable period by giving shocks of various energy through these same electrodes during the repolarization phase of paced rhythm. The above determinations were also made with the anode at the ventricular apex and the cathode at the right atrium in eight of the dogs and with the cathode at the ventricular apex and the anode at the left atrium in another eight of the dogs. In all dogs for all electrode configurations, there was an upper limit to the shock strength that induced ventricular fibrillation during the vulnerable period. Depending on the electrode combination, this upper limit of ventricular vulnerability either was not significantly different from or was slightly lower than the defibrillation threshold. The correlation coefficient between the two was highly significant for all three electrode configurations. These results support the hypothesis that successful defibrillation with epicardial electrodes requires a shock strength that reaches or exceeds the upper limit of ventricular vulnerability and that shocks slightly lower than the defibrillation threshold fail because they reinitiate ventricular fibrillation by stimulating portions of the myocardium during their vulnerable period.
A Phase I Study of Amrubicin and Carboplatin for Previously Untreated Patients with Extensive-Disease Small Cell Lung Cancer
Authors: Minoru Fukuda, Yoichi Nakamura, Takashi Kasai, Seiji Nagashima, Katsumi Nakatomi, Seiji Doi, Hirofumi Nakano, Hiroshi Takatani, Masaaki Fukuda, Akitoshi Kinoshita, Hiroshi Soda, Kazuhiro Tsukamoto, Mikio Oka, Shigeru Kohno
Journal: Journal of Thoracic Oncology (2009)
Options for Slowing the Growth of Health Care Costs
Authors: James J. Mongan, Timothy G. Ferris, Thomas H. Lee
Journal: New England Journal of Medicine (2008)

The authors review potential strategies to contain health care costs and assess each proposal's potential for success. Modifications in reimbursement to reward the practice of evidence-based medicine, expansion of the use of electronic medical records, and standardization of billing transactions to reduce administrative costs are among the strategies they view as most promising.