tbuckley/cabot-search huggingface dataset:
Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3
Authors: Dean Bok, Gary Galbraith, Ivan Lopez, Michael Woodruff, Steven Nusinowitz, Hector BeltrandelRio, Wenhu Huang, Shulei Zhao, Robert Geske, Charles Montgomery, Isaac Van Sligtenhorst, Carl Friddle, Kenneth Platt, Mary Jean Sparks, Alexander Pushkin, Natalia Abuladze, Akira Ishiyama, Ramanath Dukkipati, Weixin Liu, Ira Kurtz
Journal: Nature Genetics (2003)
A HISTOCHEMICAL STUDY OF EXPERIMENTALLY INDUCED MALIGNANT SKIN TUMOURS
Authors: J. V. DIENGDOH, J. CHAYEN
Journal: British Journal of Dermatology (1969)

Journal Article A HISTOCHEMICAL STUDY OF EXPERIMENTALLY INDUCED MALIGNANT SKIN TUMOURS Get access J. V. DIENGDOH, J. V. DIENGDOH Department of Immunology, Institute of Dermatology, St John's Hospital for Diseases of the Skin, London, E.9, and the Division of Cellular Biology, The Mathilda and Terence Kennedy Institute of Rheumatology, London, W.6 Search for other works by this author on: Oxford Academic Google Scholar J. CHAYEN J. CHAYEN Department of Immunology, Institute of Dermatology, St John's Hospital for Diseases of the Skin, London, E.9, and the Division of Cellular Biology, The Mathilda and Terence Kennedy Institute of Rheumatology, London, W.6 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 11, 1 November 1969, Pages 835–840, https://doi.org/10.1111/j.1365-2133.1969.tb15953.x Published: 01 November 1969 Article history Accepted: 26 March 1969 Published: 01 November 1969
Electrocardiography 100 Years Ago
Authors: James K. Cooper
Journal: New England Journal of Medicine (1986)

IN 1987, we will celebrate the 100th anniversary of electrocardiography.1 It may be appropriate now to review the principal contributors to the early development of the field and the critical role of one piece of equipment, the string galvanometer. The recording from the body surface of electrical potentials generated by the heart was first described in 1887,1 but early electrocardiographic instruments, which were called "electrometers," were not practical. They were delicate and inconvenient, and they had inherent distortion.2 It was only after the introduction of the sensitive and more convenient string galvanometer that clinical electrocardiography was launched. The string galvanometer . . .
Association of Epicardial Adipose Tissue Thickness by Echocardiography and Heart Rate Recovery in Metabolic Syndrome
Authors: Ferit Böyük, Bülent Özdemir, Saim Sağ, Tunay Şentürk, Aysel Aydın Kaderli, Sümeyye Güllülü, Ali Aydınlar
Journal: Journal of the American College of Cardiology (2013)
A Practice-Based Comparison of Brief Cognitive Behavioural Treatment, Two Kinds of Hypnosis and General Anaesthesia in Dental Phobia
Authors: André Wannemueller, Peter Joehren, Simon Haug, Mathias Hatting, Karin Elsesser, Gudrun Sartory
Journal: Psychotherapy and Psychosomatics (2011)

&lt;i&gt;Background:&lt;/i&gt; A practice-based study was carried out to assess the comparative effectiveness and acceptability of standardised hypnosis, hypnosis with individualised imagery, cognitive behavioural treatment (CBT) and general anaesthesia (GA) in the treatment of dental phobia. &lt;i&gt;Methods:&lt;/i&gt; A 4-group design was used with 4 repeated measurement occasions. Of an initial total of 137 dental phobics, 77 completed the study with sample sizes of between 14 and 29 patients in the 4 groups. Participants completed questionnaires of dental anxiety at the beginning of the trial, before and after the first dental appointment and again before the second dental appointment a week later. &lt;i&gt;Results:&lt;/i&gt; Standardised hypnosis evidenced a significantly higher rate of premature termination of treatment than CBT. The completer analysis showed a significant reduction of dental anxiety after CBT and individualised hypnosis compared to the GA condition. The intent-to-treat analysis showed significant improvement only after CBT. &lt;i&gt;Conclusions:&lt;/i&gt; The results suggest that CBT is the treatment of choice in dental phobia when taking both effectiveness and acceptability into account.
Hyperprolactinemia in Sarcoidosis
Authors: ROGER W. TURKINGTON
Journal: Annals of Internal Medicine (1972)

Serum prolactin levels were measured in 34 patients with extrapulmonary sarcoidosis (10 men, 24 women). Four patients had the syndrome of galactorrhea and amenorrhea. Eleven patients (3 men, 8 women) had elevated serum prolactin levels, with values ranging between 5 and 100 ng/ml. Serum prolactin levels in age-matched healthy controls and in patients with tuberculosis were less than 2 ng/ml in all cases. In three of the four patients with the galactorrhea-amenorrhea syndrome, treatment with L-dopa suppressed prolactin secretion, with cessation of galactorrhea and increased gonadotropin secretion with resumption of menses. A subsequent autopsy examination of 1 male patient with hyperprolactinemia showed sarcoid granulomata in hypothalamic nuclei, bilaterally. In six of these patients the elevated serum prolactin concentration was the only endocrine abnormality detected. These studies suggest that sarcoid granulomata may selectively destroy specific hypothalamic nuclei that normally inhibit the secretion of prolactin by the anterior pituitary. Measurement of the serum prolactin concentration may serve as a sensitive test for the detection of hypothalamic involvement in some patients with sarcoidosis.
"Author pays" publishing model: Model is concerned with vanity and profit
Authors: S. Chapman
Journal: BMJ (2003)

EDITOR—Delamothe et al assert that in the “author pays” world of medical publishing, peer review would occur exactly as it does now—the “author pays” model would not become a form of vanity publishing.1 They also say that submission fees are likely to become routine parts of the process.

But consider this. All editors receive and reject many papers that are …
Overexpression of GATA2 predicts an adverse prognosis for patients with acute myeloid leukemia and it is associated with distinct molecular abnormalities
Authors: C Vicente, I Vazquez, A Conchillo, M A García-Sánchez, N Marcotegui, O Fuster, M González, M J Calasanz, I Lahortiga, M D Odero
Journal: Leukemia (2011)
The One-Year Clause in Reciprocity.
Authors: George W. Webster
Journal: JAMA (1906)

Chicago, Nov. 24, 1906. <h3>To the Editor:</h3> —A few of the states engaging in interstate reciprocity require that the original license on which the applicant requests reciprocal recognition, shall have been issued at least one year prior to the issuance of the license under reciprocity. On June 20, 1906, the Illinois State Board of Health adopted a resolution to the effect that, after January 1, 1907, it would decline to reciprocate with any state exacting the above requirement. A short time later, the Minnesota State Board of Medical Examiners rescinded the above rule, which had previously been adopted by it, and the Wisconsin State Board of Medical Examiners likewise placed itself in accord with the Illinois Board. One of the states with which Illinois had previously reciprocated, at once terminated reciprocity, although several months intervened before the rule of the Illinois Board would become effective—an act strangely at variance with
Colonic Fecal Impaction in A Young Drug Addict
Authors: Lawrence E. Fetterman
Journal: JAMA (1967)

<h3>To the Editor:—</h3> With the increasing problem of drug usage in this country among young people, there is the possibility that multiple areas of the body may be involved detrimentally. The following case report demonstrates an atypical complication in a young male drug addict not heretofore seen at our hospital. <h3>Report of a Case:—</h3> A 24-year-old white man was seen at Providence Hospital, Mobile, Ala, in July 1964 complaining of nausea, vomiting, and upper abdominal pain of 2 1/2 weeks' duration. A recent study at another hospital revealed "duodenitis" on an x-ray examination of the upper gastrointestinal tract. Obstipation had been present one week prior to admission. An examination of the kidney, ureter, and bladder on admission demonstrated "incomplete large-bowel obstruction," and a roentgenogram taken after a barium enema the following day revealed complete obstruction at the splenic flexure (Figure). The roentgenographic report at the time of barium enema examination
Ibuprofen in rheumatoid arthritis. Clinical study of analgesic and anti-inflammatory activity.
Authors: M K Jasani, W W Downie, B M Samuels, W W Buchanan
Journal: Annals of the Rheumatic Diseases (1968)

Ibuprofen (2-4'-isobutylphenylpropionic acid) is one of a series of phenylalkanoic acids which have been found to possess analgesic, anti-inflammatory and antipyretic properties.The first of these to be successful in the treatment of rheumatoid arthritis was Ibufenac (isobutylphenylacetic acid) (Chalmers, 1963; Thompson, Stephenson, and Percy, 1964; Hart and Boardman, 1965) and the most recent of the series is Ibuprofen.Pharmacological studies have shown that the compound is between two to eight times more potent than aspirin (Adams, Cliffe, Lessel, and Nicholson, 1967).In this paper we report a double-blind cross-over study of the analgesic and anti-inflammatory activity in rheumatoid arthritis of a daily dose of 750 mg.Ibuprofen compared with aspirin 5g./day and prednisolone 15 mg./day; each drug being administered orally for a period of one week. Material and MethodsNine patients (seven females and two males) with "definite" or "classical" rheumatoid arthritis according to the diagnostic criteria of the American Rheumatism Association (Ropes, Bennett, Cobb, Jacox, and Jessar, 1959) were studied.Their mean age was 49 5 years (range 37 to 67).The mean duration of arthritis was 2 * 8 years (range 1 to 6).All patients had positive tests for rheumatoid factor by the sheep cell agglutination method (Heller, Jacobson, and Kolodny, 1949) in titres ranging from 1:32 to 1: 1024, and joint erosion was present radio- logically.The patients had received various analgesics before this study, but none had received corticosteroid therapy at any time in the course of their disease.The patients were given four courses of treatment each lasting one week: Ibuprofen 750 mg./day, aspirin 5 g./day, prednisolone 15 mg./day, and lactose as placebo.All four compounds were given by mouth in identical capsules, three capsules being taken five times daily.The courses of treatment were allocated at random, some
Analysis of the non-ionic detergent-soluble lipids of human stratum corneum*
Authors: P.J. DYKES, D.L. WILLIAMS, R. MARKS
Journal: British Journal of Dermatology (1984)

Mechanical stimulation of the skin surface in the presence of non-ionic detergent (Triton X-100)-containing buffers has been used to prepare isolated corneocytes and non-ionic detergent-soluble (NIDS) material from human stratum corneum. Analysis of the major lipid classes present in the corneocytes and NIDS material has been performed by thin layer chromatography with flame ionization detection and quantitation based on the introduction of an internal standard. Results indicate that the NIDS lipid represents a disproportionately large amount of the total stratum corneum lipid and that it differs in composition from the corneocyte lipid, there being a grcater proportion of the cholcstcryl ester fraction in the corneocytes. Both these findings support the ‘brick wall’ model of the stratum corneum and provide further evidence that the NIDS material is intercellular in nature.
Multistate foodborne hepatitis A outbreak among European tourists returning from Egypt– need for reinforced vaccination recommendations, November 2012 to April 2013
Authors: J Sane, E MacDonald, L Vold, C Gossner, E Severi, collective on behalf of the International Outbreak Investigation Team
Journal: Eurosurveillance (2015)

Binary file ES_Abstracts_Final_ECDC.txt matches
Abstract 4899: Small proline rich protein 3 (SPRR3) is a potential mediator of radiation resistance in HPV negative head and neck squamous cell carcinoma
Authors: Joshua A. Martin, Dana Gunderson, Randall J. Kimple
Journal: Cancer Research (2014)

Abstract Purpose: Head and neck cancers (HNCs) are caused by two major etiologies that have significant prognostic significance: tobacco and human papillomavirus (HPV). Patients with HPV-positive HNC have significantly better outcomes than those with HPV-negative HNC. We have previously shown that this difference may be due, in part, to increased sensitivity to radiation in HPV-positive HNCs. In order to identify additional factors that may underlie differences in radiation sensitivity, we sought to understand radiation-induced changes in global gene expression between HPV-positive and HPV-negative HNCs. Methods: A panel of eight cell lines, four HPV positive (UD-SCC2, UM-SCC47, UPCI-SCC90, 93-VU-147T) and four HPV negative (SCC1, SCC6, SCC22B, SCC1483 were treated with radiation (4 Gy) or mock and total RNA isolated 4, 24, and 48 hrs after treatment. Global gene expression was analyzed using Affymetrix Gene 1.1 ST array chips. Comparisons between untreated, baseline control, and post-radiation expression were made using ArrayStar. Alterations in differentially expressed genes were validated by Real-Time quantitative PCR (RT-qPCR). Results: Out of the top 15 hits, several members of the small proline rich repeat (SPRR) family were identified. SPRR1A, SPRR1B, and SPRR3 were significantly upregulated in HPV negative as compared to HPV-positive cell lines. Differences in expression were validated using RT-qPCR in a panel of HNC cell lines. Conclusions: We identified changes in expression of SPRR3 in HPV negative cell lines. This gene is a member of a protein family known to scavenge reactive oxygen species. Its increased expression in HPV negative HNC may mediate resistance to radiation and contribute to the poor outcomes of patients in this cohort. SPRR3 is a potential novel molecular target that could improve the outcomes of patients with HPV negative HNC. Citation Format: Joshua A. Martin, Dana Gunderson, Randall J. Kimple. Small proline rich protein 3 (SPRR3) is a potential mediator of radiation resistance in HPV negative head and neck squamous cell carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4899. doi:10.1158/1538-7445.AM2014-4899
Pulmonary Adenomatosis
Authors: Edwin W. Peterson, John D. Houghton
Journal: New England Journal of Medicine (1951)

PULMONARY adenomatosis is a rare tumor of the lung characterized by the presence of tall columnar mucus-secreting cells lining the alveolar walls, without evidence of bronchial origin or of primary adenocarcinoma elsewhere. In the past few years there has been a marked increase in the number of reported cases, with two recent reviews of the literature1 , 2 and numerous pathological discussions.A considerable difference of opinion exists concerning pulmonary adenomatosis, or alveolar-cell tumors of the human lung, including complete disbelief in the existence of this condition as a separate entity.3 The question of the existence of a true alveolar epithelium has . . .
Chronic Marijuana Use and Psychosocial Adaptation
Authors: JOEL SIMON HOCHMAN, NORMAN Q. BRILL
Journal: American Journal of Psychiatry (1973)

The authors studied the life history and adaptation of marijuana users and nonusers in a randomly selected representative sample of ten percent of the UCLA undergraduate student body. Statistically significant differences were discovered in family and personal history; educational and work performance; legal history; marital and sexual adjustment; current adaptation; political, religious, and other values; and the use of other drugs. Chronic use of marijuana was not accompanied by significant deterioration in functioning or adaptation but was accompanied by increasing acculturation into a relativistic, gratification-oriented, stimulus-seeking value system.
Clinical Importance of Emotional Problems in the Care of Patients with Burns
Authors: David A. Hamburg, Curtis P. Artz, Eric Reiss, William H. Amspacher, Rawley E. Chambers
Journal: New England Journal of Medicine (1953)

IN a study of victims of the Coconut Grove fire, Cobb and Lindemann1 recorded a high incidence of emotional disturbances soon after burning and concluded that both the psychiatrist and the social worker may play an important role in the care of disaster victims. During the past two and a half years, experience with over 400 burns2 , 3 has shown that serious emotional problems exist in extensively burned patients and that the management of these problems is an integral part of the over-all therapy.To obtain a better understanding of emotional adjustment in severe burns, 12 patients who had full-thickness burns . . .
Acute Pericarditis Associated with Infectious Mononucleosis
Authors: Henry Miller, Joseph F. Uricchio, Roswell W. Phillips
Journal: New England Journal of Medicine (1953)

DESCRIPTIONS of the syndrome of acute nonspecific or idiopathic pericarditis appearing since the report by Barnes and Burchell1 have added little to knowledge of the subject. They have, however, emphasized the variability of this type of pericarditis and have suggested to some the concept that the etiology may likewise be diverse. It is interesting that in 1947 Burchell,2 commenting on the differential diagnosis, stated: "When the diagnosis of acute pericarditis seems evident, the search for an etiologic factor should not be abandoned too quickly."Benign pericarditis has been reported under a wide variety of circumstances. The syndrome has been noted . . .
Superinduction of cyclooxygenase-2 activity in human osteoarthritis-affected cartilage. Influence of nitric oxide.
Authors: A R Amin, M Attur, R N Patel, G D Thakker, P J Marshall, J Rediske, S A Stuchin, I R Patel, S B Abramson
Journal: Journal of Clinical Investigation (1997)

Cartilage specimens from osteoarthritis (OA)-affected patients spontaneously released PGE2 at 48 h in ex vivo culture at levels at least 50-fold higher than in normal cartilage and 18-fold higher than in normal cartilage + cytokines + endotoxin. The superinduction of PGE2 production coincides with the upregulation of cyclooxygenase-2 (COX-2) in OA-affected cartilage. Production of both nitric oxide (NO) and PGE2 by OA cartilage explants is regulated at the level of transcription and translation. Dexamethasone inhibited only the spontaneously released PGE2 production, and not NO, in OA-affected cartilage. The NO synthase inhibitor HN(G)-monomethyl-L-arginine monoacetate inhibited OA cartilage NO production by > 90%, but augmented significantly (twofold) the spontaneous production of PGE2 in the same explants. Similarly, addition of exogenous NO donors to OA cartilage significantly inhibited PGE2 production. Cytokine + endotoxin stimulation of OA explants increased PGE2 production above the spontaneous release. Addition of L-NMMA further augmented cytokine-induced PGE2 production by at least fourfold. Inhibition of PGE2 by COX-2 inhibitors (dexamethasone or indomethacin) or addition of exogenous PGE2 did not significantly affect the spontaneous NO production. These data indicate that human OA-affected cartilage in ex vivo conditions shows (a) superinduction of PGE2 due to upregulation of COX-2, and (b) spontaneous release of NO that acts as an autacoid to attenuate the production of the COX-2 products such as PGE2. These studies, together with others, also suggest that PGE2 may be differentially regulated in normal and OA-affected chondrocytes.
Truncating Variants in <i>p53AIP1</i> Disrupting DNA Damage–Induced Apoptosis Are Associated with Prostate Cancer Risk
Authors: Xianshu Wang, Fengwei Wang, Ken Taniguchi, Ratnam S. Seelan, Liang Wang, Katherine E. Zarfas, Shannon K. McDonnell, Chiping Qian, Kaifeng Pan, Youyong Lu, Viji Shridhar, Fergus J. Couch, Donald J. Tindall, Jennifer L. Beebe-Dimmer, Kathleen A. Cooney, William B. Isaacs, Steven J. Jacobsen, Daniel J. Schaid, Stephen N. Thibodeau, Wanguo Liu
Journal: Cancer Research (2006)

Abstract Germ line mutations in several genes (BRCA1, BRCA2, and CHEK2) whose products are involved in the DNA damage–signaling pathway have been implicated in prostate cancer risk. To identify additional genes in this pathway that might confer susceptibility to this cancer, we analyzed a recently identified DNA damage–response gene, p53AIP1 (a gene encoding for p53-regulated apoptosis-inducing protein 1), for genetic variants in prostate cancer. Five novel germ line variants were identified. The two truncating variants (Ser32Stop and Arg21insG) were found in 3% (4 of 132) of unselected prostate tumor samples. Genotyping of the two variants in an additional 393 men with sporadic prostate cancer showed a frequency of 3.1% (12 of 393) in contrast to 0.6% (2 of 327) in 327 unaffected men (Fisher's exact test, P = 0.018), with an odds ratio (OR) of 5.1 [95% confidence interval (95% CI), 1.1-23.0]. In addition, two of six tumors carrying the truncating variants were associated with loss of heterozygosity of the wild-type alleles, suggesting that p53AIP1 may act as a tumor suppressor. We also showed that the truncated p53AIP1 was unable to induce apoptosis and suppress cell growth in HeLa and COS-7 cells. These results suggest that loss-of-function variants in p53AIP1 associated with the risk of sporadic prostate cancer and further support the concept that the genetic defects in the DNA damage–response genes play an important role in the development of prostate cancer. (Cancer Res 2006; 66(21): 10302-7)
Advertising by the AMA
Authors: Daniel J. Fink
Journal: JAMA (1972)

<h3>To the Editor.—</h3> I find it laudable that the American Medical Association is sponsoring a series of advertisements in popular publications such as<i>Newsweek, Time</i>, and the<i>New York Times</i>to point out one's personal responsibility for his own health and the AMA's interest in maintaining the nation's health. However, I think it somewhat presumptuous of the AMA, which contains less than two thirds of the nation's physicians, to claim to speak for all "America's Doctors of Medicine."
Endoscopic Injection Therapy of Forrest II and III Gastroduodenal Ulcers Guided by Endoscopic Doppler Ultrasound
Authors: B. Kohler, J. F. Riemann
Journal: Endoscopy (1993)

Endoscopic Doppler ultrasound enables the reliable identification of vessels in the base of gastroduodenal ulcers. In a prospective study including 114 patients with acute ulcer bleeding, pulsed Doppler ultrasound was able to demonstrate superficial blood vessels in the ulcer base in 62 % of 106 cases where complete Doppler assessment was possible (93 %). Agreement between the endoscopic pattern of visible vessels and the Doppler ultrasound findings was attained in only 52 % of the cases. Doppler positive ulcers (n = 66) were treated with injection therapy (if necessary, repeated), irrespective of their Forrest classification. Using such an approach, the rebleeding rate in this group decreased to less than 8 % and none of the patients died of causes related to the hemorrhage. All Doppler negative ulcers (n = 40) healed without complications or the need for endoscopic treatment; among these were 11 cases with Forrest IIa and b. We conclude that endoscopic Doppler appears to be a valuable diagnostic procedure in the assessment of bleeding ulcers, thus modifying the Forrest classification. Our concept is that Doppler positive ulcers require local endoscopic treatment, whereas Doppler negative ulcers can be treated conservatively.