tbuckley/cabot-search huggingface dataset:
Inhibition of sodium and calcium overload pathology in the myocardium: a new cytoprotective principle
Authors: L. V. Donck, M. Borgers, F. Verdonck
Journal: Cardiovascular Research (1993)

Journal Article Inhibition of sodium and calcium overload pathology in the myocardium: a new cytoprotective principle Get access Luc Ver Donck, Luc Ver Donck Department of Physiology, Life Sciences, Janssen Research Foundation, B-2340 Beerse, Belgium: L Ver Donck, M Borgers; University of Leuven, Campus Kortrijk, Kortrijk, Belgium: F Verdonck. Correspondence to Dr Ver Donck. Search for other works by this author on: Oxford Academic PubMed Google Scholar Marcel Borgers, Marcel Borgers Department of Physiology, Life Sciences, Janssen Research Foundation, B-2340 Beerse, Belgium: L Ver Donck, M Borgers; University of Leuven, Campus Kortrijk, Kortrijk, Belgium: F Verdonck. Search for other works by this author on: Oxford Academic PubMed Google Scholar Fons Verdonck Fons Verdonck Department of Physiology, Life Sciences, Janssen Research Foundation, B-2340 Beerse, Belgium: L Ver Donck, M Borgers; University of Leuven, Campus Kortrijk, Kortrijk, Belgium: F Verdonck. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 3, March 1993, Pages 349–357, https://doi.org/10.1093/cvr/27.3.349 Published: 01 March 1993 Article history Received: 13 July 1992 Accepted: 07 September 1992 Published: 01 March 1993
Alcohol consumption and psychological distress in patients with psoriasis
Authors: B. Kirby, H.L. Richards, D.L. Mason, D.G. Fortune, C.J. Main, C.E.M. Griffiths
Journal: British Journal of Dermatology (2007)

Psoriasis has been associated with excessive alcohol consumption and psychological distress.To investigate the level of alcohol use in a psoriasis population and to determine whether alcohol consumption is linked to psychological distress in patients with psoriasis.Ninety-five patients with chronic plaque psoriasis completed validated questionnaires designed to assess psychological distress, current and past alcohol consumption and self-reported physical severity of psoriasis.Using different measures of alcohol consumption, between 17% and 30% of patients were classified as having difficulties with alcohol. Thirteen per cent and 18% of patients with psoriasis believed that they had a current or past drinking problem, respectively. There was a modest but significant association between levels of anxiety and depression and weekly alcohol consumption (r = 0.29, P < 0.01 and r = 0.24, P = 0.03, respectively). Those patients who believed that they had an alcohol problem had higher levels of anxiety (P = 0.03), depression (P < 0.01) and psoriasis-associated disability (P = 0.04). There was a modest but significant association between physical severity of psoriasis and weekly alcohol consumption (r = 0.27, P = 0.02).A significant minority of patients with psoriasis consumes excessive alcohol. Patients with psoriasis should be assessed for excessive alcohol use and appropriate interventions initiated. Further studies are required to investigate whether such interventions are effective in combating alcohol abuse and in improving the psychological and physical aspects of psoriasis.
Burn Care: Infection and Smoke Inhalation
Authors: KEHL MARKLEY
Journal: Annals of Internal Medicine (1979)

Editorial Notes1 February 1979Burn Care: Infection and Smoke InhalationKEHL MARKLEY, M. D.KEHL MARKLEY, M. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-2-269 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEvery year in the United States nearly two million persons suffer burns that need medical attention. Of these, 130 000 are hospitalized, 70 000 require intensive care costing more than $300 million, and 10 000 die. Because of advances during the past decade in treatment in the major burn centers of patients with extensive burns, the survival of patients with burns up to 65% of body surface area has improved as much as 50%. Treatment differs widely even in specialized centers and because doctors who treat burns outside of these centers may be unaware of the best therapeutic measures, the...References1. MARKLEYSMALLMANTHORNTON KES: The effect of diet protein on late burn mortality. Proc Soc Exp Biol Med 135:94-99, 1970 CrossrefMedlineGoogle Scholar2. FELLERPIERSON IC: Pseudomonas vaccine and hyperimmune plasma for burned patients. Arch Surg 97:225-229, 1968 CrossrefMedlineGoogle Scholar3. ALEXANDERFISHERMACMILLAN JMB: Immunological control of Pseudomonas infection in burn patients: a clinical evaluation. Arch Surg 102:31-35, 1971 CrossrefMedlineGoogle Scholar4. MILLICANEVANSMARKLEY RGK: Susceptibility of burned mice to Pseudomonas aeruginosa and protection by vaccination. Ann Surg 163:603-610, 1966 CrossrefMedlineGoogle Scholar5. JONESROEGUPTA REJ: Low mortality in burned patients in a pseudomonas vaccine trial. Lancet 2:401-403, 1978 CrossrefMedlineGoogle Scholar6. MOYLANCHAN JC: Inhalation injury—an increasing problem. Ann Surg 188:34-37, 1978 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: KEHL MARKLEY, M. D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFunctional alterations of alveolar macrophages subjected to smoke exposure and antioxidant lazaroidsThe Prophylactic Effects of U75412E Pretreatment in a Smoke-Induced Lung Injury Rabbit ModelPiriprost Pretreatment Attenuates the Smoke-Induced Increase in 99m TcDTPA Lung ClearanceRespiratory complications in burned patients: Pathogenesis and spectrum of inhalation injuryCorticosteroid agents in intensive careInhalation of products of combustionRadionuclide evaluation of lung traumaRadionuclide imaging in the assessment of lung injury 1 February 1979Volume 90, Issue 2Page: 269-270KeywordsBody surface areaBurnsInhalation ePublished: 1 December 2008 Issue Published: 1 February 1979 Copyright & Permissions©1979 American College of PhysiciansPDF downloadLoading ...
Primary Prosthesis for Subcapital Fractures of the Neck of the Femur
Authors: Charles H. Bradford, John J. Kelleher, Paul I. O'Brien, Richard M. Kilfoyle
Journal: New England Journal of Medicine (1954)

THE determining factors in the treatment of a patient with a fracture of the neck of the femur are the age and general condition of the patient and the level of the fracture. A fracture at a very high level offers a much poorer prognosis than one located at the middle or at the base of the neck. In true subcapital types a realistic appraisal may lead the surgeon to anticipate such poor results from the standard nailing operation that he is tempted to apply a replacement prosthesis as a primary procedure. The present article offers a study of 51 . . .
Cancer Immunotherapy Comes of Age
Authors: Suzanne L. Topalian, George J. Weiner, Drew M. Pardoll
Journal: Journal of Clinical Oncology (2011)

Cancer immunotherapy comprises a variety of treatment approaches, incorporating the tremendous specificity of the adaptive immune system (T cells and antibodies) as well as the diverse and potent cytotoxic weaponry of both adaptive and innate immunity. Immunotherapy strategies include antitumor monoclonal antibodies, cancer vaccines, adoptive transfer of ex vivo activated T and natural killer cells, and administration of antibodies or recombinant proteins that either costimulate immune cells or block immune inhibitory pathways (so-called immune checkpoints). Although clear clinical efficacy has been demonstrated with antitumor antibodies since the late 1990s, other immunotherapies had not been shown to be effective until recently, when a spate of successes established the broad potential of this therapeutic modality. These successes are based on fundamental scientific advances demonstrating the toleragenic nature of cancer and the pivotal role of the tumor immune microenvironment in suppressing antitumor immunity. New therapies based on a sophisticated knowledge of immune-suppressive cells, soluble factors, and signaling pathways are designed to break tolerance and reactivate antitumor immunity to induce potent, long-lasting responses. Preclinical models indicate the importance of a complex integrated immune response in eliminating established tumors and validate the exploration of combinatorial treatment regimens, which are anticipated to be far more effective than monotherapies. Unlike conventional cancer therapies, most immunotherapies are active and dynamic, capable of inducing immune memory to propagate a successful rebalancing of the equilibrium between tumor and host.
A STUDY OF THE ETIOLOGICAL RELATIONSHIP BETWEEN PELLAGRA AND PERNICIOUS ANEMIA
Authors: Tom Douglas Spies, Warren Payne
Journal: Journal of Clinical Investigation (1933)

Pellagra and pernicious anemia are now considered by most inves- tigators to be deficiency diseases.The former has been fairly well established as a disease of dietary origin (1, 2) and the latter as a con- dition secondary to the failure of secretion of an unknown constituent of gastri( juice (3, 4).Both diseases are characterized by remissions and relapses, and often each is associated with glossitis, pyrexia, achylia gastrica, and numerous gastro-intestinal symptoms.Postmortem exam- inations show that atrophy of the gastric mucosa and involvement of the central nervous system are common findings in the patients dying of pellagra or pernicious anemia.Despite all these similarities, however,
Pulmonary artery sarcoma diagnosed using intravascular ultrasound images
Authors: Y. Okano, T. Satoh, T. Tatewaki, T. Kunieda, S. Fukuyama, N. Miyazaki, Y. Beppu
Journal: Thorax (1999)

Primary and secondary malignant intravascular tumours of the pulmonary artery occur infrequently and the diagnosis is usually delayed as symptoms and findings from conventional examinations are nonspecific.The case is presented of a patient with a pulmonary artery sarcoma, probably arising from ribs resected some years previously, in which intravascular ultrasound (IVUS) provided important diagnostic findings.
Abstract 2060: Metronomic chemotherapy (MCT): comparison of the efficacy of two combinations of drugs for the treatment of murine mammary adenocarcinomas.
Authors: María J. Rico, Leandro E. Mainetti, Herman A. Perroud, Viviana R. Rozados, O. Graciela Scharovsky
Journal: Cancer Research (2013)

Abstract Metronomic chemotherapy (MCT) refers to the chronic, equally spaced, delivery of low doses of different chemotherapeutic drugs, without extended interruptions. We have developed two combined MCT schemes for the treatment of mammary tumors: A) cyclophosphamide (Cy) 30 mg/kg/day p.o. + celecoxib (Cel) 30 mg/kg p.o. 5 times/week, and B) Cy 20 mg/kg/day p.o. + doxorubicin (Dox) 0.5 mg/kg, 3 times/week i.p. They were tested in two experimental models of mammary adenocarcinomas: I) M-406 and II) M-234p syngeneic with inbred CBi and BALB/c mice, respectively. Our present aim was to compare efficacy and toxicity of MCT combined A and B treatments in both tumor-models. There were analyzed antitumor and antimetastatic effects, survival and toxicity. The % of reduction of tumor volume of animals in the treated group with respect to control group without treatment [median (range): AI: 77.9 (50.9-89.9), AII: 84.4 (30-99.4), BI: 95.6 (57-99.6), BII: 75.5 (62.5-96.8)] didn't differ between treatments or between tumor-models (non parametric ANOVA). The % of reduction of lung metastatic burden [AI: 99.8 (97.1-99.2) AII: 99.7 (98.7-100), BI: 90.6 (35.9-96.6), BII: 90 (48.4-99.3)] was significantly different among all the groups (P&amp;lt;0.01); Dunn's post-test showed differences in AII vs BII (P&amp;lt;0.05). The analysis of survival showed higher values in treated groups, being the % of survival increase with respect to controls [AI: 56.5 (4.3-56.5) AII: 77.6 (5.3-84.2), BI: 110.9 (60-308.2), BII: 36.1 (12.4-113)] did not reach statistical significance (P=0.054). The treatments toxicity, evaluated by evolution of body weight and total leucocytes count, was similar in both tumor-models and treatments. The antitumor therapeutic efficacy was comparable in both MCT schemes and so was the toxicity generated by them. The combination Cy + Cel was superior than Cy + Dox related to antimetastatic power, suggesting its potential use at the adjuvant setting. That observation, together with the advantage that represents the oral administration of the Cy + Cel drug combination, thus leading to a better quality of life for tumor bearers, points at its election for the treatment of mammary tumors with metronomic chemotherapy. Citation Format: María J. Rico, Leandro E. Mainetti, Herman A. Perroud, Viviana R. Rozados, O. Graciela Scharovsky. Metronomic chemotherapy (MCT): comparison of the efficacy of two combinations of drugs for the treatment of murine mammary adenocarcinomas. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2060. doi:10.1158/1538-7445.AM2013-2060
THE PRESENT STATUS OF CONSERVATISM IN THE SURGICAL TREATMENT OF TUBES AND OVARIES.
Authors: JOHN EGERTON CANNADAY
Journal: JAMA (1906)

We all know that even the least of the atoms has its definite value and its purpose to fulfill in the harmonious whole of Nature's plan. We have been long taught when a limb was injured, a hand mangled or an abscess formed to make every effort to save the part. Until rather recent years these saving methods did not seem to apply to the pelvic organs of women at all. <h3>SURGICAL TREATMENT OF OVARIES.</h3> In view of the fact that pelvic lesions constitute a large percentage of every surgeon's cases, their treatment becomes a matter of momentous importance. The recognition of the value of the internal secretions or trophic influences of the ovaries has had a world-wide influence as regards the surgical treatment of these organs. The elder Emmet expressed the hope that future generations might be allowed to go uncastrated. More than twenty years ago Schröder first advocated
Adenovirus Transduction is Required for the Correction of Diabetes Using Pdx-1 or Neurogenin-3 in the Liver
Authors: Alfred Y Wang, Anja Ehrhardt, Hui Xu, Mark A Kay
Journal: Molecular Therapy (2007)

The regeneration of insulin-producing cells in vivo has emerged as a promising method for treating type I diabetes. Pancreatic duodenal homeobox-1 (Pdx-1), NeuroD, and Neurogenin-3 (Ngn3) are pancreatic transcription factors important for the development of insulin-producing cells in the liver. Other groups have demonstrated that adenoviral-mediated transgene expression of these transcription factors in the liver can reverse hyperglycemia in diabetic mice. We delivered Pdx-1 and Ngn3 to the livers of diabetic mice using adeno-associated virus (AAV) serotype 8, a vector that has been shown to result in non-toxic, persistent, high level expression of the transgene. We were unable to correct hyperglycemia in mice with streptozotocin-induced diabetes using AAV vectors expressing Pdx-1 and Ngn3. However, when we co-delivered these transcription factor expression cassettes in non-viral vectors with an irrelevant adenoviral vector, we were able to correct hyperglycemia in diabetic animals. Further studies demonstrated that an antigen-dependent immune response elicited by the adenoviral capsid together with the expression of a pancreatic transcription factor was required for restoration of serum insulin levels by the liver. Our results suggest that a host response to adenovirus in combination with expression of a pro-endocrine pancreas transcription factor is sufficient to induce insulin production in the livers of diabetic mice.
Inhibiting the Cyclin-Dependent Kinase CDK5 Blocks Pancreatic Cancer Formation and Progression through the Suppression of Ras-Ral Signaling
Authors: Georg Feldmann, Anjali Mishra, Seung-Mo Hong, Savita Bisht, Christopher J. Strock, Douglas W. Ball, Michael Goggins, Anirban Maitra, Barry D. Nelkin
Journal: Cancer Research (2010)

Abstract Cyclin-dependent kinase 5 (CDK5), a neuronal kinase that functions in migration, has been found to be activated in some human cancers in which it has been implicated in promoting metastasis. In this study, we investigated the role of CDK5 in pancreatic cancers in which metastatic disease is most common at diagnosis. CDK5 was widely active in pancreatic cancer cells. Functional ablation significantly inhibited invasion, migration, and anchorage-independent growth in vitro, and orthotopic tumor formation and systemic metastases in vivo. CDK5 blockade resulted in the profound inhibition of Ras signaling through its critical effectors RalA and RalB. Conversely, restoring Ral function rescued the effects of CDK5 inhibition in pancreatic cancer cells. Our findings identify CDK5 as a pharmacologically tractable target to degrade Ras signaling in pancreatic cancer. Cancer Res; 70(11); 4460–9. ©2010 AACR.
Mail-In Paper Strip vs. Microcolumn Technique for Measurement of Glycosylated Hemoglobin
Authors: Charles W Slemenda, David G Marrero, S Edwin Fineberg, Patricia S Moore, Reid Gibson
Journal: Diabetes Care (1990)

We compared glycosylated hemoglobin (GHb) determined from capillary blood samples on paper strips with a standard microcolumn technique in a cross-sectional observational study with laboratories blinded to duplicate samples. Both the standard and the filter strip laboratories were provided with 80 uniquely identified blood samples from 40 individuals. Each laboratory ran duplicate analyses on each sample, yielding 160 GHb values. The within-laboratory correlations between blinded duplicates were 0.98 for the standard (microcolumn technique) and 0.94 for the filter paper (affinity technique) laboratories. The between-laboratory correlations ranged from 0.69 to 0.77. When classifying patients by quartile of glycemic control, the laboratories agreed on 60% of the patients. In an effort to identify sources of between-laboratory variability, varying quantities of blood were applied to strips and reanalyzed. Five microliter drops always yielded inflated estimates of GHb. These data suggest that the estimates of GHb obtained from mail-in paper strips, although internally consistent, differ in important ways from standard laboratory values, reemphasizing the need for caution in the interpretation of interlaboratory and intermethod comparisons.
GONOCOCCEMIA WITH RECOVERY
Authors: WILLIAM FILLER
Journal: JAMA (1933)

A case of gonorrheal sepsis with recovery is apparently so rare as to be worthy of reporting. A careful study of the literature reveals not many more than a dozen proved cases on record in which recovery has taken place. Reports of such cases have been made by Thayer,<sup>1</sup>Silvestrini, Dieulafoy, Marfan and Debré, Tapie and Riser, O'Brien and Bancker,<sup>2</sup>Jenkins,<sup>3</sup>Cabot,<sup>4</sup>Garlock,<sup>5</sup>Wheeler and Cornell,<sup>6</sup>and Rubenstone and Israel.<sup>7</sup>The case I am about to report is the seventh case on record in which recovery has taken place without a resultant cardiac lesion. I feel, however, that the small number of cases of recovery from gonorrheal sepsis on record is a false index to the actual number of recoveries from gonococcemia that occur. The difficulty in obtaining cultures of the gonococci and the failure to suspect the possibility of gonorrheal sepsis in
Chloroquine and Psoriasis
Authors: THOMAS G. OLSEN
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 April 1981Chloroquine and PsoriasisTHOMAS G. OLSEN, M.D.THOMAS G. OLSEN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-4-546_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: For the past 20 years there have been sporadic reports in the literature of flares of psoriasis coincident with the intake of antimalarial drugs (1-3). Nevertheless, the relation remains controversial because of the lack of prospective data and reports documenting actual improvement of psoriasis, arthritis, or both while patients are taking antimalarials (4, 5). I recently saw the following case.A 58-year-old man with a 9-year history of psoriasis whose disease was well controlled on twice-weekly PUVA (oral methoxsalen and high-intensity long-wave ultraviolet light) treatments, experienced a flare of the skin disease while traveling in Brazil. Two...References1. CORNBLEET T. Action of synthetic antimalarial drugs on psoriasis. J Invest Dermatol. 1956;26:435-6. CrossrefMedlineGoogle Scholar2. BAKER H. The influence of chloroquine and related drugs on psoriasis and keratoderma blenorrhagicum. Br J Dermatol. 1966;78:161-6. CrossrefGoogle Scholar3. BIELICKÝ T. Light-sensitive psoriasis and antimalarial drugs. J Invest Dermatol. 1963;41:1-2. MedlineGoogle Scholar4. COURMIA E and NOUN M. Treatment of pustular psoriasis and pustular bacterid with quinacrine (Atabrine). Arch Dermatol Syph. 1953;68:337-8. CrossrefGoogle Scholar5. O'QUINN S, KENNEDY C, and NAYLOR L. Psoriasis, ultraviolet light, and chloroquine. Arch Dermatol. 1964;90:211-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: THOMAS G. OLSEN, M.D.Affiliations: Yale University School of Medicine New Haven, CT 06510 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySafety of Short-Term Treatments with Oral Chloroquine and Hydroxychloroquine in Patients with and without COVID-19: A Systematic ReviewAssessment of safety of the major antimalarial drugsThe Role of Antimalarials in the Exacerbation of PsoriasisAntimalarial Drug ToxicityImmunomodulating Drugs in the Management of Psoriatic ArthritisSevere falciparum malariaErythemato-Papulo-Squamous DiseasesSELECTED DRUG COMPLICATIONS AND TREATMENT CONFLICTS IN THE PRESENCE OF COEXISTENT DISEASESTerbinafine therapy may be associated with the development of psoriasis de novo or its exacerbation: Four case reports and a review of drug-induced psoriasisErythematöse, erythematosquamöse und papulöse HauterkrankungenTreatment of psoriatic arthritisSevere and complicated malariaDrugs in exacerbation of psoriasisPlaquenil-induced erythrodermaAntiprotozoal drugs 1 April 1981Volume 94, Issue 4_Part_1Page: 546-547KeywordsAntimalarialsArthritisChloroquinePsoralen UV APsoriasisResearch designSkin diseases ePublished: 1 December 2008 Issue Published: 1 April 1981 PDF downloadLoading ...
The History of Ophthalmology, vol 3: The Renaissance of Ophthalmology in the 18th Century, Part 1
Authors: Joseph Kiernan
Journal: JAMA (1985)

Hirschberg's 11-volume<i>The History of Ophthalmology</i>was at last published in English beginning in 1982, with a smooth-reading translation by Frederick Blodi, MD. Each volume is richly illustrated and written with an eye toward detail. This volume deals with the rapid expansion of knowledge of techniques that occurred in the 18th century. The first half deals with ideas and methods such as the dispute over the nature of the cataract, cataract extraction procedures, and surgical procedures of the pupil. In the second half, the progress of ophthalmology is reviewed country by country. Perhaps the most stimulating part of this book to the modern-day ophthalmologist is the review of the surgical techniques of cataract extraction. Long, direct quotes from the then-leading surgeons make for historical accuracy and exciting reading. These are placed side by side with superb illustrations. Galen's teaching that an intraocular opacity lay anterior to the crystalline lens was