tbuckley/cabot-search huggingface dataset:
Therapy of noninfectious granulomatous skin diseases with fumaric acid esters
Authors: K. Breuer, R. Gutzmer, B. Volker, A. Kapp, T. Werfel
Journal: British Journal of Dermatology (2005)

Journal Article Therapy of noninfectious granulomatous skin diseases with fumaric acid esters Get access K. Breuer, K. Breuer Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Strasse 5, 30449 Hannover, Germany Kristine Breuer, MD. E‐mail: breuer.kristine@mh‐hannover.de Search for other works by this author on: Oxford Academic Google Scholar R. Gutzmer, R. Gutzmer Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Strasse 5, 30449 Hannover, Germany Search for other works by this author on: Oxford Academic Google Scholar B. Völker, B. Völker Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Strasse 5, 30449 Hannover, Germany Search for other works by this author on: Oxford Academic Google Scholar A. Kapp, A. Kapp Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Strasse 5, 30449 Hannover, Germany Search for other works by this author on: Oxford Academic Google Scholar T. Werfel T. Werfel Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Strasse 5, 30449 Hannover, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 152, Issue 6, 1 June 2005, Pages 1290–1295, https://doi.org/10.1111/j.1365-2133.2005.06585.x Published: 01 June 2005 Article history Accepted: 13 November 2004 Published: 01 June 2005
Plasminogen activators and their inhibitors in synovial fluids from normal, osteoarthritis, and rheumatoid arthritis knees.
Authors: C Belcher, F Fawthrop, R Bunning, M Doherty
Journal: Annals of the Rheumatic Diseases (1996)

OBJECTIVES: To establish baseline concentrations of plasminogen activators and their inhibitors in normal knee synovial fluids, and to compare them with well characterised osteoarthritis (OA) and rheumatoid arthritis (RA) knee fluids. METHODS: A total of 26 normal subjects, 71 patients with OA, and 17 patients with RA underwent knee aspiration. Patients with OA were subclassified according to presence of nodal generalised OA (NGOA) and synovial fluid calcium pyrophosphate crystals. Clinical assessment of inflammation (graded 0-6) was undertaken in OA and RA patients. Plasminogen activator (PA), plasminogen activator inhibitor (PAI), and urokinase-type PA receptor (uPAR) antigen concentrations were determined by enzyme linked immunosorbent assay. The species of PAs present were determined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis. RESULTS: Concentrations of all antigens (uPA, tissue-type PA (tPA), uPAR, and PAI-1), were significantly greater in RA than OA; those in OA were significantly greater than normal. The concentrations showed no direct association with clinically assessed inflammation of the knee. In normal fluids, no associations with age were observed. Antigen concentrations (uPA, tPA, and uPAR) in NGOA differed from those in other subclasses of OA, but the species of PA present did not appear to vary between disease groups. The predominant PA appeared to have identity with uPA. CONCLUSION: Because of the greater concentrations of these antigens in OA compared with normal fluids, OA cannot be used as a surrogate normal control in studies of the PA/PAI system. Alteration of the PA/PAI system was confirmed in RA and OA knee fluids, with greater changes evident in RA. The finding of different concentrations of PA antigens in NGOA compared with other OA fluids further supports a different pathogenic mechanism in this subset.
An Address on the Science of Clinical Medicine
Authors: A. Garrod
Journal: BMJ (1926)

A VOYAGE down the Thames f i-m its upper reaches to London gives a mental picture of the river, and of its significance, wholly different fromii that obtaiined by olooking at it from the Tower Bridge.So also it seemed to , e, when I was asked to speak to you on this opening day of a niew session, tlidt one who hias lived through such a period of unrivalled progress in miiedicine ad d surgery as the last h alf-century should have a message to deliver to thiose whlo see before them the fruits of that progress, but only as accompllised facts.
P2-254: Pulmonary toxicity in patients treated with a combination of gemcitabine (G) associated to docetaxel (D) or vinorelbine (V) for advanced non-small cell lung cancer (NSCLC): outcome data on a randomized phase II study
Authors: Emilio Esteban, Noemi Villanueva, Isabel Muñiz, Yolanda Fernández, Joaquin Fra, Maria Luque, Paula Jimenez, Beatriz Llorente, Marta Capelan, Angel J. Lacave
Journal: Journal of Thoracic Oncology (2007)
ASSOCIATION BETWEEN USE OF ANTI-ANGINAL MEDICATIONS FOR STABLE CORONARY DISEASE AND RATES OF PERCUTANEOUS CORONARY INTERVENTION: A REPORT FROM THE NCDR&amp;reg;
Authors: William Borden, John Spertus, Alvin I. Mushlin, Matthew Roe, Lisa Kaltenbach, Rita Redberg
Journal: Journal of the American College of Cardiology (2012)
Erratum to: Clinical practice guideline on diagnosis and treatment of hyponatraemia
Authors: Goce Spasovski, Raymond Vanholder, Bruno Allolio, Djillali Annane, Steve Ball, Daniel Bichet, Guy Decaux, Wiebke Fenske, Ewout J. Hoorn, Carole Ichai, Michael Joannidis, Alain Soupart, Robert Zietse, Maria Haller, Sabine van der Veer, Wim Van Biesen, Evi Nagler
Journal: Intensive Care Medicine (2014)
Enforced Expression of Superoxide Dismutase 2/Manganese Superoxide Dismutase Disrupts Autocrine Interleukin-6 Stimulation in Human Multiple Myeloma Cells and Enhances Dexamethasone-Induced Apoptosis
Authors: David R. Hodge, Weihua Xiao, Benjamin Peng, James C. Cherry, David J. Munroe, William L. Farrar
Journal: Cancer Research (2005)

Autocrine pathways of proliferative and anti-apoptotic growth factors represent a serious impediment to the treatment of many types of tumors. In particular, interleukin-6 (IL-6), a pleiotropic cytokine known to play a critical role in the survival and growth of multiple myeloma cells, participates in an autocrine stimulation loop that serves to inhibit the induction of apoptosis during chemotherapy. Manganese superoxide dismutase (MnSOD) is an important antioxidant enzyme encoded by the SOD2 gene that attenuates oxidative free radicals in the mitochondria by catalyzing the formation of hydrogen peroxide from superoxide radicals. Transcription factor activity and binding is influenced by the oxidative state of cells, and dysregulation of MnSOD levels can result in abnormal patterns of gene expression. In the human multiple myeloma cell line IM-9, an autocrine IL-6 loop exists, which enables the cell to resist the effects of dexamethasone, a common treatment for multiple myeloma. Here, we show that SOD2 expression is epigenetically silenced in IM-9 cells, and replacement of MnSOD reduces cell proliferation and partially restores susceptibility to dexamethasone. The restoration of MnSOD also serves to decrease the expression levels of IL-6 by reducing the ability of activator protein-1, an important mediator of IL-6 expression in multiple myeloma cells, to bind to its enhancer site. These results show the importance of free radical-mediated dysregulation of autocrine growth factor loops in tumor cells and their effect on cell growth and response to chemotherapy.
Levels of mast-cell growth factors in plasma and in suction skin blister fluid in adults with mastocytosis: Correlation with dermal mast-cell numbers and mast-cell tryptase
Authors: Knut Brockow, Cem Akin, Mary Huber, Linda M. Scott, Lawrence B. Schwartz, Dean D. Metcalfe
Journal: Journal of Allergy and Clinical Immunology (2002)
On the Best Methods of Diagnosing and Correcting the Errors of Refraction
Authors: H. Juler
Journal: BMJ (1884)

W oTn:Uimilar oaesf oseiwed byxMiBft>,;3iIe>and'M'rt 6 WIker, that a11 the reaes of death ifoIlhwib 9uleetien in oph- tValmnitis had nQt benn reeftded;l ed 4Ais, de hi.stll inore !ingly of opunion rthat .th4t a .edeJer, i e^uoeetiou iin suqh c4ses6..He Was oomewbhattnislhed sthat no, one had veutured to doub* tw4qonneetion, 8 Mr.. oltihinson 4md 1): Mol1iVe, of bIoua, hf4 Jth,put ion reedrd, ki.eeeyjdeiewayj,that theyebnsiderel thf-m s !ono dgnger.w 4 1ither hand vn Grife nd; Ptfeeser ArIt .p,thgave warniigjeo mcerinug .the.danger incurred.
Major histocompatibility complex-expressing nonhematopoietic astroglial cells prime only CD8+ T lymphocytes: astroglial cells as perpetuators but not initiators of CD4+ T cell responses in the central nervous system.
Authors: J D Sedgwick, R Mössner, S Schwender, V ter Meulen
Journal: The Journal of Experimental Medicine (1991)

The potential of cells within the central nervous system (CNS) to initiate T lymphocyte responses is not known and was the subject of this study. Using the ability of virgin T lymphocytes to proliferate in a primary response to allogeneic determinants on antigen-presenting cells (APC), we have examined the capacity of major histocompatibility complex (MHC)-expressing astroglial cells to act as stimulators of primary and secondary T cell responses. Neither freshly isolated astrocytes nor primary astrocyte cultures pretreated with interferon gamma (IFN-gamma) to upregulate MHC class I and II expression stimulated unfractionated lymph node (LN) cell populations in the primary mixed lymphocyte reaction. In mixing experiments, astrocytes did not inhibit the T cell response to allogeneic LN stimulators. Purified responder CD4+ T cells also were not stimulated to proliferate or secrete interleukin 2 (IL-2) by MHC class I- and II-expressing astrocytes. In contrast to their inability to stimulate virgin, alloreactive CD4+ T cells, astrocytes were able to specifically stimulate an alloreactive CD4+ T cell line. Unprimed CD8+ T cells, however, exhibited some weak autonomous proliferation to astrocyte stimulators but this response was only substantial in the presence of exogenous IL-2, the latter predominantly being a CD4+ T cell product. Those CD8+ T cells responding in the presence of IL-2 were mainly T cell receptor alpha/beta+ IL-2 receptor (alpha chain)+, and a majority had shifted from high to low CD45R expression. Given the virtual dependence of CD8+ T cells in these studies, on CD4+ T cell help, and the complete absence of activation of this latter subset by astrocytes, it is clear that in the context of this resident CNS cell, further activation of either T cell subset by astrocytes within the CNS can only follow priming by another type of APC. The implications of these results for the induction of T cell responses in the CNS are discussed.
Must Good HMOs Go Bad? — The Commercialization of Prepaid Group Health Care
Authors: Robert Kuttner
Journal: New England Journal of Medicine (1998)

Prepaid group health care began in the 1940s as an insurgent, even radical form of medicine. At the time, few Americans had health insurance. The early programs would later be called group or staff models — closed systems with salaried doctors and an emphasis on prevention. The members sacrificed an often hypothetical freedom of choice for security and continuity of care. The doctors sacrificed independent, fee-for-service practice for a stable salary, a collegial setting, and a social ethic. Such plans were fiercely resisted by organized medicine.1,2 The shift in prepaid group health care from an insurgent social movement to . . .
The Balance between Sphingosine and Sphingosine-1-Phosphate Is Decisive for Mast Cell Activation after Fc∈ Receptor I Triggering
Authors: Eva E. Prieschl, Robert Csonga, Veronica Novotny, Gary E. Kikuchi, Thomas Baumruker
Journal: The Journal of Experimental Medicine (1999)

Over the last few years, sphingolipids have been identified as potent second messenger molecules modulating cell growth and activation. A newly emerging facet to this class of lipids suggests a picture where the balance between two counterregulatory lipids (as shown in the particular example of ceramide and sphingosine-1-phosphate in T lymphocyte apoptosis) determines the cell fate by setting the stage for various protein signaling cascades. Here, we provide a further example of such a decisive balance composed of the two lipids sphingosine and sphingosine-1-phosphate that determines the allergic responsiveness of mast cells. High intracellular concentrations of sphingosine act as a potent inhibitor of the immunoglobulin (Ig)E plus antigen-mediated leukotriene synthesis and cytokine production by preventing activation of the mitogen-activated protein kinase pathway. In contrast, high intracellular levels of sphingosine-1-phosphate, also secreted by allergically stimulated mast cells, activate the mitogen-activated protein kinase pathway, resulting in hexosaminidase and leukotriene release, or in combination with ionomycin, give cytokine production. Equivalent high concentrations of sphingosine-1-phosphate are dominant over sphingosine as they counteract its inhibitory potential. Therefore, it might be inferred that sphingosine-kinase is pivotal to the activation of signaling cascades initiated at the Fc epsilon receptor I by modulating the balance of the counterregulatory lipids.
Exstrophy of Bladder. Correction.
Authors: J. Rilus Eastman
Journal: JAMA (1899)

To the Editor.\p=m-\Ihavebeen very much interested in the recent articles in the Journal on the seeing of the blood-cor- puscles in one's own retina.So far as I am concerned it has not only never been a difficult matter for me to see them, but has been a very difficult matter in microscopic work to keep the field free from them.To see them best, it is well to prepare a slide with blood for comparison.Any good microscope stand with "B" eye-piece and 1/4-inch objective may be used.Focus
Margaret McCartney: Politicians: if you love the NHS then set it free from your non-evidence based meddling
Authors: M. McCartney
Journal: BMJ (2015)

The leaders of all UK political parties profess great love for the NHS. Everyone has ideas about its weaknesses and how to fix them. Many political commentators see the service as key to the imminent general election: it’s the closest thing we have to a national religion, which—at least in public—we all agree to believe in. 

Danny Boyle’s dancing nurses at the Olympics’ opening ceremony gave us permission to be proud of the NHS. Healthcare staff (including me) often plead for less political interference in our day to day work. Can politicians understand what it’s like when our elderly and multimorbid patients need more care, when we are in a recruitment crisis and under pay freezes, with daft targets and a blameful media, all of which result in staff working …
Spirometry in a Medical Clinic
Authors: Stuart W. Rosner
Journal: JAMA (1965)

Discriminant function analysis was performed on several measurements from the forced expiratory spirogram obtained in a group of first-visit patients at a medical clinic. The analysis provided a discriminant function score which is a predictive index of the presence or absence of respiratory dysfunction. The forced vital capacity as a percentage of the predicted vital capacity and the forced expiratory volume at two seconds as a percentage of the forced vital capacity were the prime discriminants. The spirometric score value was a helpful diagnostic aid to the physician in detecting a ventilation abnormality.
Comparison of Vildagliptin and Rosiglitazone Monotherapy in Patients With Type 2 Diabetes
Authors: Julio Rosenstock, Michelle A. Baron, Sylvie Dejager, David Mills, Anja Schweizer
Journal: Diabetes Care (2007)

To compare the efficacy and tolerability of vildagliptin and rosiglitazone during a 24-week treatment in drug-naïve patients with type 2 diabetes.This was a double-blind, randomized, active-controlled, parallel-group, multicenter study of 24-week treatment with vildagliptin (100 mg daily, given as equally divided doses; n = 519) or rosiglitazone (8 mg daily, given as a once-daily dose; n = 267).Monotherapy with vildagliptin and rosiglitazone decreased A1C (baseline = 8.7%) to a similar extent during the 24-week treatment, with most of the A1C reduction achieved by weeks 12 and 16, respectively. At end point, vildagliptin was as effective as rosiglitazone, improving A1C by -1.1 +/- 0.1% (P < 0.001) and -1.3 +/- 0.1% (P < 0.001), respectively, meeting the statistical criterion for noninferiority (upper-limit 95% CI for between-treatment difference < or =0.4%). Fasting plasma glucose decreased more with rosiglitazone (-2.3 mmol/l) than with vildagliptin (-1.3 mmol/l). Body weight did not change in vildagliptin-treated patients (-0.3 +/- 0.2 kg) but increased in rosiglitazone-treated patients (+1.6 +/- 0.3 kg, P < 0.001 vs. vildagliptin). Relative to rosiglitazone, vildagliptin significantly decreased triglycerides, total cholesterol, and LDL, non-HDL, and total-to-HDL cholesterol (-9 to -16%, all P < or = 0.01) but produced a smaller increase in HDL cholesterol (+4 vs. +9%, P = 0.003). The proportion of patients experiencing an adverse event was 61.4 vs. 64.0% in patients receiving vildagliptin and rosiglitazone, respectively. Only one mild hypoglycemic episode was experienced by one patient in each treatment group, while the incidence of edema was greater with rosiglitazone (4.1%) than vildagliptin (2.1%).Vildagliptin is an effective and well-tolerated treatment option in patients with type 2 diabetes, demonstrating similar glycemic reductions as rosiglitazone but without weight gain.
Phospholipase C-β3 Regulates FcɛRI-Mediated Mast Cell Activation by Recruiting the Protein Phosphatase SHP-1
Authors: Wenbin Xiao, Jun-ichi Kashiwakura, Hong Hong, Hiroki Yasudo, Tomoaki Ando, Mari Maeda-Yamamoto, Dianqing Wu, Yuko Kawakami, Toshiaki Kawakami
Journal: Immunity (2011)
Plasma oxidative parameters and mortality in patients with severe burn injury
Authors: Cristiane Ritter, Michael Andrades, Márcio Guerreiro, Leonardo Zavaschi, Daniel Pens Gelain, Luis Fernando Souza, Cyntia A. Ribeiro, Nadine Clausell, Sérgio Menna-Barreto, José Cláudio F. Moreira, Felipe Dal-Pizzol
Journal: Intensive Care Medicine (2003)
Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide
Authors: Yoshinori Nagai, Rintaro Shimazu, Hirotaka Ogata, Sachiko Akashi, Katsuko Sudo, Hidetoshi Yamasaki, Shin-Ichi Hayashi, Yoichiro Iwakura, Masao Kimoto, Kensuke Miyake
Journal: Blood (2002)
Abstract 3179: The head and neck cancer biomarker wiki: A tool for data mining and biomarker meta-analyses.
Authors: Rebecca Ceder, Pekka Kohonen, Roland C. Grafström
Journal: Cancer Research (2013)

Abstract Biomarkers that accurately predict outcome or treatment response is lacking for most human tumor types, including for common and well-studied cancers like head and neck squamous cell carcinoma (HNSCC). With the aim to summarize existing genomic analysis and biomarker data into a format analyzable with bioinformatics processing tools, we set out to develop a biomarker wiki for HNSCC, hypothesizing that meta-analyses would reveal novel and potentially clinically useful sets of biomarker genes. We applied the user-friendly MediaWiki interface for collecting data in the public domain, and separated the results under the categories: primary tumor profiling, metastasis profiling, cell line profiling and treatment response. The information was captured applying controlled and standardized vocabularies, including with data storage in the multi-omics Investigation/Study/Assay (ISA-Tab) format. Bioinformatics-driven meta-analyses of results from currently over 50 publications indicate that the wiki serves to accurately identify common gene patterns, gene ontologies, molecular networks and key regulator genes within and among the respective categories. Additionally, independent validations relative other databases such as the Human Gene Expression Map, the Human Protein Atlas and the cBio Cancer Genomics Portal confirm many associations, including with significant correlations to poor outcome for gene sub-sets. Overall, the wiki results so far agree with the hypothesis under testing, suggesting novel biomarker genes/signatures for future clinical assessment. On completion, we foresee a query-enabling update-friendly knowledge platform for head and neck cancer studies in the public domain. Citation Format: Rebecca Ceder, Pekka Kohonen, Roland C. Grafström. The head and neck cancer biomarker wiki: A tool for data mining and biomarker meta-analyses. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3179. doi:10.1158/1538-7445.AM2013-3179
Optimal timing of doses of chenic acid in patients with gall stones.
Authors: D P Maudgal, R Bird, T C Northfield
Journal: BMJ (1979)

Sixteen patients with gall stones were treated with chenic acid (14-16 mg/kg/day) given at three different times in random order for one month each. Before treatment the mean (+/- SE of mean) cholesterol saturation index (SI) of fasting gall-bladder bile was 1.28 +/- 0.06. During bedtime administration of chenic acid the mean SI fell to 0.78 +/- 0.04, which was significantly lower than that obtained with administration in the morning (0.92 +/- 0.05) or with three divided doses at mealtimes (0.92 +/- 0.04). The bile remained supersaturated in seven patients when they received a single morning dose, in five patients when they received mealtime doses, but in only one patient when a single bedtime dose was given. There was no significant difference in side effects between the three different dose timings, or in the proportion of bile acids present in the bile as chenic acid. This enhanced effect obtained with bedtime administration may be due to the enterohepatic circulation of bile acids being maintained during overnight fasting.
Successful Treatment With Dabrafenib (GSK2118436) in a Patient With Ganglioglioma
Authors: Kent C. Shih, Mythili Shastry, Jeffrey T. Williams, Peter F. Jelsma, Steven R. Abram, Kanyalakshmi Ayyanar, Howard A. Burris, Jeffrey R. Infante
Journal: Journal of Clinical Oncology (2014)
Medical Records of Neonates
Authors: E. J. Noble
Journal: BMJ (1969)

Varicella zoster virus (VZV)-induced vasculopathy is an uncommon cause of stroke in a young immunocompetent host. Owing to scarcity of data of VZV-induced vasculopathy and lack of awareness about this condition and its diagnostic test, these cases may be easily missed. In this case, we report an immunocompetent host presenting right-side hemiplegia with motor aphasia and complete loss of vision in the left eye due to complete occlusion of the left common carotid artery without any history of skin rash preceding stroke. Cerebrospinal fluid analysis for varicella antibody revealed very high titres and CT aortogram demonstrated aortoarteritis with occlusion of left common carotid artery. To our knowledge, varicella zoster vasculopathy-associated aortoarteritis has not been described in the literature.