tbuckley/cabot-search huggingface dataset:
Tc-99m Sestamibi Uptake in Metastatic Prostate Carcinoma
Authors: GEOFFREY R. STOREY, PETER DAVIES, ROBERT COOPER
Journal: Clinical Nuclear Medicine (2000)

Chest pain developed in a 67-year-old man with a history of prostate carcinoma and he was referred for a myocardial perfusion scan. A Tc-99m sestamibi–dipyridamole study showed impaired coronary artery flow reserve to the interventricular septum and a fixed perfusion defect in the inferior wall of the left ventricle, consistent with previous myocardial infarction. Increased sestamibi uptake in an irregular pattern in multiple ribs was noted incidentally. The serum prostate-specific antigen concentration was markedly elevated at 84.3 μg/l (normal, <4.0 μg/l). A whole-body bone scan showed corresponding multiple foci of increased tracer accumulation in the ribs and elsewhere in the axial and appendicular skeleton, consistent with widespread prostatic carcinoma metastases in bone. Tc-99m sestamibi uptake has been reported in a wide range of benign and malignant tumors, but accumulation in prostate carcinoma has not been previously described. FIGURE 1Fig. 1: Anterior and left anterior oblique views of the left thorax after intravenous injection of Tc-99m sestamibi at rest (left and right images) and left anterior oblique view after sestamibi injection during exercise (center image) show irregular uptake of tracer in multiple ribs.FIGURE 2Fig. 2: A Tc-99m MDP whole-body bone scan shows multiple foci of increased tracer accumulation throughout the axial and appendicular skeleton consistent with widely disseminated prostate carcinoma metastases in the bone.
USE OF THE WORD "ADENOCARCINOMA"
Authors: John J. Andujar
Journal: JAMA (1960)

To the Editor:—  The excellent article by Linden and co-workers entitled Validity of Pathological Diagnosis of Breast Cancer, inThe Journal, May 14, page 143, is reassuring to the practicing pathologist. The fact that 95.6% of the diagnoses of breast cancer were confirmed by three independent experts on material arising from a large number of institutions is a tribute to the uniformly high level of practice of anatomic pathology in the United States and to the American Board of Pathology.  Less pleasing to the practicing pathologist is the tabulation showing an incidence in these breast cancers of 41.2% adenocarcinoma and 10.3% ductal carcinoma. It is difficult to believe that eminent pathologists believe that duct carcinoma constitutes only 10% of breast cancers. In fact, the article tries to gloss over the unfortunate classification by referring to comparisons between the histological and histogenetic considerations. Although, in the words of Fred Waldorf Stewart,
THE DEVELOPMENT IN VITRO OF PARTICLES FROM CYTOPLASM
Authors: Eric L. Nelson
Journal: The Journal of Experimental Medicine (1958)

Spherical particles, 1 to 10 microns in diameter, resulted from the incubation at 37°C. of distilled water lysates of erythrocytes with deoxyribonucleic acid (DNA). The particles consisted of 88 per cent hemoglobin and 12 per cent DNA (dry weight basis). An unknown factor, presumably an enzyme, present only in fresh red cell lysates, was required for particle development. Particle size was a function of the pH of the reaction mixture. The pH range was 4.8–5.8. It was possible to trap extraneous proteins and polysaccharides in pockets within the hemoglobin particles during their development to the exclusion of some of the hemoglobin. The amount of any one substance so trapped was proportional to its concentration in the reaction mixture. Some practical applications of the particles, as a means for making particulate various soluble substances (enzymes, antigens, antibiotics), are suggested.
Approach to surgery in United Kingdom should be shaken up
Authors: P. A Isaac
Journal: BMJ (2001)

EDITOR—With respect to the article by Wilmore and Kehlet on the management of patients in fast track surgery, the NHS needs to overhaul its surgical model completely.1 Although there will always be a need for hospital based surgery for major procedures and for less major procedures in higher risk patients, many procedures could be performed more efficiently in outpatient surgical facilities.

When my father reached the top of the waiting list and had elective wrist surgery in an NHS hospital, he spent a night in …
Physiological Adjustments to Altitude Changes
Authors: David B. Dill
Journal: JAMA (1968)

Physiological adaptation to high altitude involves rapid responses in respiration and slower responses in nervous, muscular, and cardiovascular system. An excellent criterion of adaptation is measurement of the capacity for supplying oxygen to tissues, oxygen consumption (Vo<sub>2</sub>maximum). Such measurements reveal four stages of response. At 10,000 feet, for example, stage 1 is reached in minutes; Vo<sub>2</sub>max declines 10%. In one to three days, stage 2, it declines another 10%; this is the stage of unpleasant subjective responses. In a few weeks, stage 3, performance approaches the level of stage 1. Red blood cell volume increases in stage 4, reaching its maximum after a year or more. Performance improves pari passu: Eventually sea-level performance can be achieved at 13,200 feet. The above course of events is idealized. Individuals vary widely in rate of adaptation; the amount of exercise plays a role, and age is a factor. Above
Strategies of coping and quality of life in women with alopecia
Authors: S. Schmidt, T.W. Fischer, M.M. Chren, B.M. Strauss, P. Elsner
Journal: British Journal of Dermatology (2001)

Measurements of the quality of life (QoL) have recently become an integral part of dermatological studies. Our hypothesis is that QoL in patients with certain diseases can be affected by strategies of coping behaviour, as well as by personality traits.The aim of this study was to explore the particular correlation between QoL and strategies of coping in female patients with alopecia.Fifty female patients, diagnosed with either diffuse or androgenetic alopecia, were evaluated by the use of Hairdex, an instrument developed to measure QoL in patients with hair loss. Most patients also underwent additional psychological assessments.Findings indicated that patients with highly visible hair loss reported a more negative impact on four Hairdex dimensions (functioning, emotions, self-confidence and stigmatization) than patients whose hair loss was only slightly visible. However, a subgroup of patients, with non-visible symptoms of hair loss, showed striking signs of psychological disturbance. These disturbed patients displayed either dysmorphophobic or affective disorder tendencies.Future studies using QoL as an instrument in research on patients with alopecia should consider that in cases of female alopecia these measurements may be affected by psychological disturbances.
THE HUMAN SECRETORY IMMUNOGLOBULIN SYSTEM: IMMUNOHISTOLOGICAL LOCALIZATION OF γA, SECRETORY "PIECE," AND LACTOFERRIN IN NORMAL HUMAN TISSUES
Authors: D. R. Tourville, R. H. Adler, J. Bienenstock, T. B. Tomasi
Journal: The Journal of Experimental Medicine (1969)

The immunohistological localization of gammaA, secretory "piece" (SP), and lactoferrin (LF) in the mucosae of a variety of normal human tissues was investigated using specific fluoresceinated antisera. gammaA staining was localized in the apical portion of the mucosal epithelium, intercellular spaces, basement membrane area, and plasma cells of the interstitium or lamina propria of a number of normal human tissues. SP was ubiquitous in the mucosal epithelium of all tissues studied which included parotid and submaxillary glands, bronchi, pancreas, GI tract, sweat glands, kidney, and gall bladder. In addition, SP staining was localized in the intercellular spaces and on the surface of the epithelial cells lining the lumen of the secretory glands. No SP staining was observed in the plasma cells of the interstitium or lamina propria surrounding the secretory glands in these tissues, and no SP staining was observed in sections of normal spleen or lymph node tissue. SP staining was observed in the sweat glands, pancreas, and kidney in the absence of gammaA staining. LF was much less ubiquitous in the epithelial cells of the various tissues studied and appeared to be restricted primarily to the acinar epithelium of the bronchial mucosae, parotid, and submaxillary salivary glands, and was also found in renal tubular cells. A hypothetical model for the transport of gammaA and SP across mucosal membrane epithelium is presented.
Impact of the NICE guideline recommending cessation of antibiotic prophylaxis for prevention of infective endocarditis: before and after study
Authors: M. H. Thornhill, M. J. Dayer, J. M. Forde, G. R. Corey, V. H. Chu, D. J. Couper, P. B. Lockhart
Journal: BMJ (2011)

<b>Objective</b> To quantify the change in prescribing of antibiotic prophylaxis before invasive dental procedures for patients at risk of infective endocarditis, and any concurrent change in the incidence of infective endocarditis, following introduction of a clinical guideline from the National Institute for Health and Clinical Excellence (NICE) in March 2008 recommending the cessation of antibiotic prophylaxis in the United Kingdom. <b>Design</b> Before and after study. <b>Setting</b> England. <b>Population</b> All patients admitted to hospital in England with a primary or secondary discharge diagnosis of acute or subacute infective endocarditis. <b>Main outcome measures</b> Monthly number of prescriptions for antibiotic prophylaxis consisting of a single 3 g oral dose of amoxicillin or a single 600 mg oral dose of clindamycin, and monthly number of cases of infective endocarditis, infective endocarditis related deaths in hospital, or cases of infective endocarditis with a possible oral origin for streptococci. <b>Results</b> After the introduction of the NICE guideline there was a highly significant 78.6% reduction (P&lt;0.001) in prescribing of antibiotic prophylaxis, from a mean 10 277 (SD 1068) prescriptions per month to 2292 (SD 176). Evidence that the general upward trend in cases of infective endocarditis before the guideline was significantly altered after the guideline was lacking (P=0.61). Using a non-inferiority test, an increase in the number of cases of 9.3% or more could be excluded after the introduction of the guideline. Similarly an increase in infective endocarditis related deaths in hospital of 12.3% or more could also be excluded. <b>Conclusion</b> Despite a 78.6% reduction in prescribing of antibiotic prophylaxis after the introduction of the NICE guideline, this study excluded any large increase in the incidence of cases of or deaths from infective endocarditis in the two years after the guideline. Although this lends support to the guideline, ongoing data monitoring is needed to confirm this, and further clinical trials should determine if antibiotic prophylaxis still has a role in protecting some patients at particularly high risk.
Functional Abdominal Pain in Childhood: From Etiology to Maladaptation
Authors: Ilva Elena Schulte, Franz Petermann, Meinolf Noeker
Journal: Psychotherapy and Psychosomatics (2009)

&lt;i&gt;Objective:&lt;/i&gt; To review the extant literature on functional abdominal pain in childhood through the lens of the developmental psychopathology perspective and to systematize research results by means of a two-stage pathway model in which the emergence of functional abdominal pain and its potential transition into a somatoform adjustment disorder is outlined. &lt;i&gt;Methods:&lt;/i&gt; Using electronic searches for published studies and previous reviews about functional abdominal pain. &lt;i&gt;Results:&lt;/i&gt; An association of functional abdominal pain with internalizing symptoms, poor well-being of family members, major life events and daily stressors is found. The impact of stress on pain seems to be moderated by the children’s coping style and their perceived competence and self-efficacy to manage the pain experience. There is evidence for the influence of modeling and operant mechanisms on pain experiences. A new term, ‘somatoform adjustment disorder’, and its relation to functional abdominal pain is discussed. &lt;i&gt;Conclusions:&lt;/i&gt; It seems that those children with functional abdominal pain who cannot adapt to the pain indeed run the risk of developing a somatoform adjustment disorder.
Let's Stop Boxing in the Olympics and the US Military
Authors: Joe D. Haines
Journal: JAMA (1994)

<h3>To the Editor.</h3> —While I agree with some of Dr Lundberg's rationale<sup>1</sup>in curtailing boxing, I believe that he is off base in asking the armed forces to ban boxing. I would like to refer you to COL Larry Donnithorne's recent book,<i>The West Point Way of Leadership</i>,<sup>2</sup>to understand why boxing is an integral part of a soldier's training: Boxing causes more anxiety in the cadets than any other aspect of physical training. Many cadets—like many civilians—have never taken a punch in the nose. Suddenly they come face to face with their fear. As far as the cadets are concerned, the second worse thing that can happen to them is losing the match. But far and away the worst is that they may turn and run out of the ring. If they do, they must return, or they will not graduate. They must learn to face fear,
An Atlas of Head and Neck Surgery
Authors: Bromley S. Freeman
Journal: JAMA (1974)

This atlas is truly a monument to the author and the publisher as well as to a superb medical artist, Robert Wabnitz, and is undoubtedly the most complete atlas or textbook on surgery of the head and neck that has been compiled. The numerous detailed illustrations of the surgical techniques are presented simply, clearly, yet completely. This second edition not only fulfills the intent of the first edition "to encompass in one set of values the related regional procedures of the head and neck" but has amplified other aspects not stressed initially, such as vascular surgery. It fulfills the need for the specialists from the varying fields of general surgery, plastic and reconstructive surgery, otolaryngology, maxillofacial surgery, and neurosurgery as well as vascular surgery. A few of the vintage procedures, mainly reconstructive, have aged poorly and have been supplanted or greatly revised in recent years. An example is the simplistic
Ga-67 and TI-201 Imaging in Sarcoidosis Involving the Myocardium
Authors: TSUNEMI TAJIMA, TSUNEKATSU NAITO, YUTAKA DOHI, TATSUYA MIYAMAE
Journal: Clinical Nuclear Medicine (1981)

TAJIMA, TSUNEMI M.D.; NAITO, TSUNEKATSU M.D.; DOHI, YUTAKA M.D.; MIYAMAE, TATSUYA M.D. Author Information
Evaluating the Quality of Medical Care
Authors: John W. Williamson
Journal: New England Journal of Medicine (1973)

In this time of rapidly increasing interest in assessing the quality of medical care, many investigators, including myself, spend much time advocating their favorite method of evaluation. A refreshing and objective analysis of five methods is presented in this issue of the Journal by Brook and Appel in the Special Article, "Quality of Care Assessment: Choosing a method for peer review."In this study, the authors have collected data for the assessment of the quality of medical care provided to 296 patients with urinary-tract infection, hypertension or peptic ulcer. The assessment of quality was done by a team of physicians . . .
Oxygen tension, concentration, and humidification
Authors: D. W. Cugell
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sensitive in vivo cell detection using size-optimized superparamagnetic nanoparticles
Authors: Jesse Trekker, Cindy Leten, Tom Struys, Vera V Lazenka, Barbara Argibay, Liesbeth Micholt, Ivo Lambrichts, Willem Van Roy, Liesbet Lagae, Uwe Himmelreich
Journal: Biomaterials (2013)
Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers
Authors: Eric C. Kauffman, Christopher J. Ricketts, Soroush Rais-Bahrami, Youfeng Yang, Maria J. Merino, Donald P. Bottaro, Ramaprasad Srinivasan, W. Marston Linehan
Journal: Nature Reviews Urology (2014)
Spontaneous Fractures in Rheumatoid Arthritis
Authors: R. Haider, G. Storey
Journal: BMJ (1962)

Spontaneous fractures in rheumatoid arthritis are said to be rare (Baer, 1941 ; Rosenberg, 1958) apart from steroid therapy. This is surprising, since rheumatoid arthritis occurs particularly in women of the age-group when spontaneous fractures might be expected (Albright et at., 1941). The fractures which occur during steroid therapy bave been extensively studied (Boland, 1951 ; Demartini et al., 1952 ; Rosenberg, 1958), particularly when this therapy is prolonged (Gascon and Grignon, 1960), but apart from this the subject has received little attention. Den Oudsten and Speyer (1959) found little difference between the number of fractures in a group of rheuma toid patients and those in a control group. However, Fineschi (1957) has drawn attention to spontaneous fractures in rheumatoid arthritis and describes many of their features. Spontaneous fractures have also been described in Still's disease (Badley and Ansell, 1960). This paper reports five cases of rheumatoid arthritis where spontaneous fractures occurred in the absence of any other known cause. All five patients were typical rheumatoid arthritics and fulfil the criteria of definite rheumatoid arthritis laid down by the American Rheumatism Association (Ropes et al., 1957). Case 1 A woman of 65 had suffered from rheumatoid arthritis for 16 years and had been treated with salicylates, phenyl butazone, and gold. She was admitted to hospital in 1958 because of an exacerbation of her arthritis affecting the shoulders, hands, and lower limbs. She improved with bed rest, analgesics, and physiotherapy. During convalescence while walking she experienced pain in the right ankle, and a radiograph showed a fracture through the right fibula (Fig. 1). This healed with bed rest and strapping. Investigations.?Hb, 67%. White blood count, 6,400/ cmm., differential count normal. Plasma proteins, 7.5 g./ 100 ml. (albumin, 5.6 g., globulin 1.9 g.). Rose, test positive. No lupus erythematosus cells in peripheral blood. Sedimentation rate, 60 mm. in one hour. Serum alkaline phosphatase, 12.2 K.A. units. Serum inorganic phosphorus, 3.4 mg./100 ml. Serum calcium, 10 mg./100 ml. Urine normal She improved and was discharged from hospital. Five months later, however, she returned with pain in the left ankle; this followed a stumble while walking. On June 16, 1959, radiography showed a crack fracture through the left fibula and a commencing fracture in the left tibia (Fig. 2). She was treated with bed rest, and on July 24 a radiograph showed union of the fibula, while the tibial fracture was more obvious and involved the whole shaft (Fig. 3). Union again occurred after bed rest.
Should the Health Community Promote Smokeless Tobacco (Snus): Comments from British American Tobacco
Authors: Justine Williamson, Christopher Proctor
Journal: PLoS Medicine (2007)

Chapman and Freeman question the tobacco industry's aims on snus, and whether these aims can be consistent with harm reduction [1]. We cannot speak on behalf of the industry as a whole. However, we at British American Tobacco understand that cigarette smoking is a major cause of serious and fatal diseases, and we believe that the use of Swedish-style snus products, while not harmless, is substantially less harmful than cigarette smoking [2]. We are piloting snus in several countries outside of Sweden as a response to those public health stakeholders who have told us they believe that snus, properly regulated, can contribute to reducing the net public health impact of tobacco use.

We believe adult consumers of tobacco products would benefit from the enactment of a regulatory framework that facilitates consistent, accurate, and meaningful communications on the relative health risks of smoking, using snus, or abstaining entirely from tobacco use. While ideally this framework would be developed and agreed upon under the Framework Convention for Tobacco Control, the recent second Conference of the Parties to the Framework Convention did not address oral tobacco products and has not assigned a high priority to tobacco product regulation in this area. Given this, we think national governments should develop a regulatory framework for snus. In doing so, we think that governments should be mindful of the concerns expressed by Chapman and Freeman.

We agree with the recently released preliminary report from the European Union's Scientific Committee on Emerging and Newly Identified Health Risks, which states that “the balance of these effects [beneficial versus adverse effects on smoking prevalence] will be highly dependent upon the marketing of the product, the health messages delivered with it, and the extent to which switching to smokeless tobacco products as a harm reduction strategy is endorsed by health professionals and their organisations” [3].

We acknowledge that some have concerns with regard to our interest in snus as a less harmful alternative to cigarettes. We seek to work with the public health community and regulators to achieve a reduction in the public health impact of tobacco use.