tbuckley/cabot-search huggingface dataset:
693 ARE MEN AND WOMEN TREATED DIFFERENTLY WITH REGARD TO HEPATOCELLULAR CARCINOMA (HCC)? ANALYSIS OF A NATIONWIDE INPATIENT DATABASE FROM THE UNITED STATES
Authors: S. Cauble, A. Abbas, L. Balart, L. Bazzano, Sabeen Medvedev, Sofia Medvedev, N. Shores
Journal: Journal of Hepatology (2012)
Work-Related Carpal Tunnel Syndrome-Reply
Authors: Neil Maizlish, Kate Cummings, Lawrence J. Fine, Thomas D. Matte, Edward L. Baker
Journal: JAMA (1990)

<h3>In Reply.—</h3> We believe Dr Nathan may have misunderstood the purpose of the Santa Clara physician survey. The survey was not intended to assess whether repetitive, forceful, or awkward hand movements increase the risk of CTS. That association has been firmly established in numerous studies.<sup>1-3</sup> Dr Nathan cites a single survey<sup>4</sup>as evidence against an association between occupational factors and CTS, even though workers in jobs requiring both forceful and highly repetitive hand movements did have a higher prevalence (61%) of slowed median nerve conduction than did workers in the lowest-risk jobs (28%). Reasons why an even stronger effect of ergonomic factors was not observed may include the following: the small number of subjects (23) in the highest-risk group; the exclusion of subjects with previous surgery for CTS; exposure misclassification (objective measurements of force and repetitiveness were not made); survivor bias (symptomatic workers tend to leave high-risk jobs);
You Don't Have to Be a Neuroscientist to Forget Everything With Triazolam—But It Helps
Authors: Michael J. Kushner
Journal: JAMA (1988)

To the Editor.  —I am surprised by the report of Morris and Estes 1 that described transient global amnesia (TGA) in three travelers using triazolam and alcohol. In these unconvincing case reports, the authors are confused in their use of the term TGA . Transient global amnesia refers to a self-limited syndrome that is characterized by the abrupt onset of the inability to learn new materials; a variable period of retrograde amnesia, generally with the preservation of remote memory; the preservation of personal identity; and the absence of confounding features such as head trauma, drug effect, or other risk factors for confusion or amnesia. 2   In the report, none of these individuals were examined for the presence of amnesia or for the inability to learn new materials. In general, individuals with TGA, firmly established by neurological examination during the attack, have an incredible lack of initiative and drive and may show
Postmortem functional changes in coronary and cerebral arteries from humans and monkeys
Authors: N. TODA, T. OKAMURA, I. SHIMIZU, Y. TATSUNO
Journal: Cardiovascular Research (1985)

Contractile responses to 30 mmol·litre−1K+ of helical strips of coronary arteries from human cadavers did not change within 5 h after death; however, they were suppressed 8 h after death. In coronary arteries from monkey cadavers, the K+-induced contractions did not significantly differ within the first 5 h, but were suppressed 12 h after death. On the other hand, K+-induced contractions were retained without deterioration in cerebral artery strips from human cadavers 20 to 24 h after death and those from monkey cadavers 8 to 16 h. Acetylcholine caused contractions of human coronary arteries, but caused only a relaxation of monkey coronaries which was abolished by rubbing off the endothelium. These responses were attenuated by no more than K+-induced contractions up to 12 h after death. Maximum contractions induced by noradrenaline, histamine and serotonin remained the same in human coronary arteries for 3 to 5 h after death. Similar magnitudes of contraction were elecited by noradrenaline in human cerebral arteries up to 20 h after death. It appears that the reactivity of human coronary arteries to K+and other vasoconstrictor agents used is normally retained for at least 6 h after death and that of human cerebral arteries for up to 24 h.
Pattern recognition receptors: A contemporary view on liver diseases
Authors: Gyongyi Szabo, Angela Dolganiuc, Pranoti Mandrekar
Journal: Hepatology (2006)

Pattern recognition receptors (PRRs) function as sensors of microbial danger signals enabling the vertebrate host to initiate an immune response. PRRs are present not only in immune cells but also in liver parenchymal cells and the complexity of the cell populations provide unique aspects to pathogen recognition and tissue damage in the liver. This review discusses the role of different PRRs in pathogen recognition in the liver, and focuses on the role of PRRs in hepatic inflammation, cholestasis, ischemia, repair and fibrosis. PRRs as novel therapeutic targets are evaluated.
RECENT OBSERVATIONS ON STREPTOMYCES PELLETIERI INFECTION IN THE TRANSVAAL
Authors: G. H. FINDLAY, H. F. ROUX
Journal: British Journal of Dermatology (1971)

Some variants of Streptomyces pelletieri have been isolated recently in the Transvaal from 2 patients and from river water. The red-grain mycetomata produced were chronic but mild and did not destroy bone. The river isolates were probably part of the normal flora of the water, differing from the pathogenic strains mainly in their optimum temperature requirements.
Congenital Deformities of the Spine
Authors: Walter W. Huurman
Journal: JAMA (1984)

The most difficult problems encountered in treatment of spinal deformities are seen in those abnormalities that are secondary to a congenital bony anomaly. To date, individual articles have dealt with one or more types of anomaly but none have been all encompassing. Textbooks on spinal problems have had only short chapters discussing such congenital deformities. In this text, encompassing 343 pages in 16 chapters, the author brings his unparalleled experience in treating 1,500 cases of congenital deformity.  The completeness of the work is mirrored in the effort extended in its preparation. The author spent a six-month sabbatical leave from academic and clinical responsibilities to review, analyze, and draw conclusions from a total of 1,250 cases ultimately deemed adequate for review purposes. The successes and failures in caring for these 1,250 patients with problems that included failure of spinal segmentation or formation as well as midline defects, treated nonoperatively and surgically,
Traumatic childhood experiences associated with chronic health problems, study finds
Authors: M. McCarthy
Journal: BMJ (2014)

Children who have had one or more traumatic experiences in childhood have higher rates of chronic disease than those who have not had such experiences, even after adjusting for factors such as race, ethnicity, and household income, a US study has found.

These findings indicate that the US health system could improve the immediate and long term health of children by focusing on those who have had, or are at risk of having, adverse childhood experiences, the study said.1 This should include developing strategies to promote resilience among the young, which seems to reduce the impact of such experiences.

Lead author Christina D Bethell, a professor at the Johns Hopkins Bloomberg School of Public Health, and colleagues used data from the 2011-12 National Survey of Children’s Health, a nationally representative sample of 95 677 US children aged 0-17 years. They assessed the associations …
USE OF SULFONAMIDE SOLUTIONS IN THE NOSE
Authors: Forrest W. Merica
Journal: JAMA (1942)

To the Editor:—  I read inThe Journal, March 21, a communication from Dr. Walter D. Klestadt and a reply to this communication by Dr. Russell Fletcher concerning the use of sulfonamide solutions in the nose, and in view of the fact that there is some controversial discussion I should like to add something from my experience on the use of a solution of sodium sulfathiazole in the nose.  After publication of Dr. F. M. Turnbull's article last year I began using a 5 per cent solution of sodium sulfathiazole by means of nasal tamponage. These packs were inserted, for the most part, in the middle meatuses following the application of 5 per cent cocaine and were left in place from fifteen to thirty minutes. The frequency of treatment varied with different patients, sometimes daily, sometimes several days apart.  I have used this solution on more than 300 patients, and
Role of secretory events in modulating human neutrophil chemotaxis.
Authors: J I Gallin, D G Wright, E Schiffmann
Journal: Journal of Clinical Investigation (1978)

The relationship between neutrophil polymorphonuclear leukocyte (PMN) locomotion and the exocytosis of neutrophil cytoplasmic granules was studied by assessing these processes in cells migrating through micropore filters and by measuring the effects of degranulating stimuli on PMN chemotaxis, orientation, adhesiveness, and ability to bind the chemoattractant f-Met-Leu-[3H]Phe. Studies of cells migrating through cellulose nitrate filters indicated that concentrations of f-Met-Leu-Phe optimal for exocytosis were greater than those optimal for chemotaxis and actually inhibited cell migration. In other studies incubation of PMNs with concentrations of secretagogues causing exocytosis of 30% or greater PMN lysozyme increased cell adhesiveness and inhibited chemotaxis. PMNs that had secreted more than 30% lysozyme appeared round, did not orient in a gradient of chemoattractant, and were capable of significantly less f-Met-Leu-[3H]Phe binding than were control cells. The decreased binding of f-Met-Leu-Phe was not associated with hydrolysis of chemotactic peptide by washed cells, although peptide hydrolysis was caused by cell products secreted extracellularly after vigorous exocytosis. In contrast, when only 10--15% cellular lysozyme was released f-Met-Leu-Phe binding was enhanced significantly and there was no depression of chemotaxis. The data indicate limited exocytosis of intracellular granule contents is associated with increased availability of PMN cehmotactic factor receptors. Vigorous exocytosis is associated with inactivation of chemotactic responsiveness related to increase cell adhesiveness, decreased PMN binding of chemotactic factors, and to hydrolysis of chemoattractants by factors secreted extracellularly.
Orthopaedic care of children with myelomeningocele: a modern programme of rehabilitation.
Authors: E. H. Strach
Journal: BMJ (1967)

An ever-increasing number of children suffering from con genital paraplegia due to myelomeningocele are being referred to the orthopaedic surgeon for treatment of skeletal deformities and for rehabilitation. The management of these children is often so complex that it presents a veritable challenge to the orthopaedic surgeon. The aim of this paper is to show some of the problems he has to deal with and to suggest some lines of management. This study is based on personal experience with 173 patients (98 male, 75 female) who were referred for orthopaedic treat ment during the past 10 years. They represent, therefore, a selected group of cases, but they are a typical cross-section of cases seen in the orthopaedic department. I must emphasize that the intensive programme of rehabilita tion described here is not accepted by all workers in this field. The ages of the patients at the time of review or at the time of death were: under 5 years, 104 + 10 deaths; 5-10 years, 45 -f-1 death ; 10-17 years, 12 + 1 death. The primary myelo meningocele operation was performed in the first 24 hours in 81 ; at 2 to 7 days in 44 ; at 8 days to 6 months in 24 ; and later in 11. The timing of the operation in two patients was unknown and in 11 cases operation was not performed. Hydrocephalus was present in 130 cases (75%). Ventriculo atrial shunt operation was performed in the first month of life in 54 children and at a later date in 65 children. Spontaneous arrest occurred in 11 cases. Paralysis of the legs was severe in 89 children (above the twelfth dorsal segment), moderate in 43 (above the fifth lumbar segment), slight in 15 (at or below first sacral segment), and 'spastic in 8. Paralysis was not present in 18 children. Urinary diversion was performed in 23 cases. Size of the Problem.?There is no increase in the number of children born with this malformation. With modern initial treatment of the myelomeningocele and the hydrocephalus many more children survive than formerly. The incidence of myelo meningocele in the United Kingdom is 2.5 to 3 per 1,000 live births. It has been estimated that in England and Wales 2,500 children are born every year with this malformation. Fifty per cent, will reach the age of 5 and a quarter of these will have no handicap and three-quarters will have a physical or mental defect. Eighty-four per cent, of all survivors are mentally normal.
494 Two-state modeling of virological and biochemical efficacy plus liver biopsies demonstrate efficacy of adefovir dipivoxil in HBeAg-negative chronic hepatitis B over four or five years
Authors: S. Hadziyannis, N. Tassopoulos, T.T. Chang, E.J. Heathcote, G. Kitis, M. Rizzetto, E. Marcellin, S.G. Lim, Z. Goodman, S. Arterbum, J. Ma, K. Borroto-Esoda, E. Mondou, S. Chuck
Journal: Journal of Hepatology (2006)
Contact and photocontact sensitivity problems associated with thiourea and its derivatives: a review of the literature and case reports
Authors: A. DOOMS-GOOSSENS, M.T. CHRISPEELS, H. VEYLDER, R. ROELANDTS, L. WILLEMS, H. DEGREEF
Journal: British Journal of Dermatology (1987)

Thiourea and its derivatives have been widely used in industry since the beginning of this century, but it was only in the late 1960s that reports of cases of contact dermatitis to these compounds began to appear in the literature. This literature is reviewed. We have observed eight cases of diphenylthiourea sensitivity in patients sensitive to adhesive tape. Four cases are presented of sensitivity to thiourea compounds in diazo-sensitized paper. Three of these patients were contact allergic to dimethylthiourea, and the other was contact and photocontact allergic to thiourea. These skin problems were mainly induced by airborne contact.
674 The innovative real time Breath-ID® test system diagnoses and predicts the extent of hepatic injury in patients with non-alcoholic fatty liver disease
Authors: M. Braun, O. Pappot, E. Zuckerman, J. Sulkes, Y. Kitai, M. Moreno, O. Cohen, H. Shmilovitz-Weiss, Y. Rotman, D. Zamirs, S. Melnik, R. Tur-Kaspa, Z. Ben-Ari
Journal: Journal of Hepatology (2006)
Antitumor Activity of γδ T Cells Reactive against Cytomegalovirus-Infected Cells in a Mouse Xenograft Tumor Model
Authors: Christel Devaud, Eric Bilhere, Séverine Loizon, Vincent Pitard, Charlotte Behr, Jean-François Moreau, Julie Dechanet-Merville, Myriam Capone
Journal: Cancer Research (2009)

gammadelta T cells recognize stress-induced autoantigens and contribute to immunity against infections and cancer. Our previous study revealed that Vdelta2-negative ((neg)) gammadelta T lymphocytes isolated from transplant recipients infected by cytomegalovirus (CMV) killed both CMV-infected cells and HT29 colon cancer cells in vitro. To investigate the antitumor effects of Vdelta2(neg) clones in vivo, we generated hypodermal HT29 tumors in immunodeficient mice. Concomitant injections of Vdelta2(neg)clones, in contrast to Vdelta2(+) cells, prevented the development of HT29 tumors. Vdelta2(neg) clones expressed chemokine C-C motif receptor 3 (CCR3) and migrated in vitro in response to chemokines secreted by HT29 cells, among which were the CCR3 ligands macrophage inflammatory protein-1delta and monocyte chemoattractant protein-4. More importantly, a systemic i.p. treatment with Vdelta2(neg) clones delayed the growth of HT29 s.c. tumors. The effect of in vivo gammadelta T-cell passive immunotherapy on tumor growth could be reverted by addition of a blocking anti-CCR3 antibody. gammadelta T-cell passive immunotherapy was dependent on the cytotoxic activity of the gammadelta effectors toward their targets because Vdelta2(neg) clones were not able to inhibit the growth of A431 hypodermal tumors. Our findings suggest that CMV-specific Vdelta2(neg) cells could target in vivo cancer cells, making them an attractive candidate for antitumor immunotherapy.
Platelets, Fatty Acids and Thrombosis
Authors: JOHN C. HOOK, EMORY D. WARNER, WILLIAM E. CONNOR
Journal: Circulation Research (1967)

The sodium salts of stearic, oleic, linoleic and linolenic acids were added to human washed platelet suspensions and platelet-rich citrated plasma. Aggregation of the platelets was measured microscopically and with a turbidimetric method. All of the fatty acids had the ability to produce aggregation when added to washed platelets, but stearic acid, a long-chain saturated fatty acid, was more potent than were the unsaturated acids when added to platelet-rich plasma. Aggregation of platelets by fatty acids required the presence of calcium ions and the aggregation was irreversible. The addition of albumin diminished the aggregating effects of fatty acids, but microscopic aggregates still formed in most instances. Subnormal aggregation was noted when sodium stearate was added to platelet-rich plasma from a patient with a severe deficiency of factor XII (Hageman factor). Thus, fatty acids are now known to have two potential thrombogenic effects: platelet aggregation and the activation of clotting factors involved in the early stages of blood coagulation.
Sept4, a Component of Presynaptic Scaffold and Lewy Bodies, Is Required for the Suppression of α-Synuclein Neurotoxicity
Authors: Masafumi Ihara, Nobuyuki Yamasaki, Akari Hagiwara, Ai Tanigaki, Ayumi Kitano, Rie Hikawa, Hidekazu Tomimoto, Makoto Noda, Masashi Takanashi, Hideo Mori, Nobutaka Hattori, Tsuyoshi Miyakawa, Makoto Kinoshita
Journal: Neuron (2007)
Cancer hazards of the pharmacy.
Authors: G M Bonser
Journal: BMJ (1967)

4-Ethyl3ulphonylnaphthalene-l-sulphonamide (anticonvulsant and diuretic).j-2-p-Alethoxybenzenesulphonamido-5-isobutyl-1 ,3,4-thiadiazole (hypoglycaemic agent). Group 1 ArsenicNeubauer (1947) collected from the literature 143 cases of skin cancer attributed to the medicinal use of arsenic, and Hueper (1957) recorded a further 37 cases.In Neubauer's BRITONu129
Unusual Demonstration of Supernumerary Bronchial Lobe by Pulmonary Imaging
Authors: REN-SHYAN LIU, CHIH-YI CHEN, SHIN-HWA YEH
Journal: Clinical Nuclear Medicine (1986)

A supernumerary lobe surrounded by the collapsed right lobe was demonstrated by the Tc-99m MAA perfusion and Xe-133 ventilation studies.
HRG1 Is Essential for Heme Transport from the Phagolysosome of Macrophages during Erythrophagocytosis
Authors: Carine White, Xiaojing Yuan, Paul J. Schmidt, Erica Bresciani, Tamika K. Samuel, Dean Campagna, Caitlin Hall, Kevin Bishop, Monica L. Calicchio, Ariane Lapierre, Diane M. Ward, Paul Liu, Mark D. Fleming, Iqbal Hamza
Journal: Cell Metabolism (2013)
Time Spent Sedentary and Active and Cardiometabolic Risk Factors in Children—Reply
Authors: Ulf Ekelund, Lauren Sherar, Ashley Cooper
Journal: JAMA (2012)

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Endotoxin "priming" potentiates lung vascular abnormalities in response to Escherichia coli hemolysin: an example of synergism between endo- and exotoxin.
Authors: D Walmrath, H A Ghofrani, S Rosseau, H Schütte, A Cramer, W Kaddus, F Grimminger, S Bhakdi, W Seeger
Journal: The Journal of Experimental Medicine (1994)

The pore-forming hemolysin of Escherichia coli (HlyA), an important virulence factor in extraintestinal E. coli infections, causes thromboxane generation and related vasoconstriction in perfused rabbit lungs (Seeger, W., H. Walter, N. Suttorp, M. Muhly, and S. Bhakdi. 1989. J. Clin. Invest. 84:220). We investigated the influence of pulmonary vascular "priming" with endotoxin on the responsiveness of the lung to a low-dose HlyA challenge. Rabbit lungs were perfused with Krebs Henseleit buffer containing 0.1-100 ng/ml Salmonella abortus equii lipopolysaccharide (LPS) for 60-180 min. This treatment caused protracted release of tumor necrosis factor into the recirculating medium, but did not induce significant alterations of pulmonary hemodynamics and fluid balance. At a dose of 1 ng/ml, HlyA elicited only moderate thromboxane release (&amp;lt; 200 pg/ml) and pulmonary artery pressure increase (&amp;lt; or = 6 mmHg) in control lungs. Acceleration and potentiation of both the metabolic and vasoconstrictor response occurred in lungs primed with LPS. This priming effect displayed dose (threshold integral of 0.1-1 ng/ml LPS) and time dependencies (threshold integral of 60-90 min LPS incubation). Maximum thromboxane release and pulmonary artery pressure increase surpassed the responses to HlyA in nonprimed lungs by more than 15-fold. Cyclooxygenase inhibition and thromboxane-receptor antagonism blocked these effects. These data demonstrate that LPS priming synergizes with HlyA challenge to provoke vascular abnormalities that are possibly relevant to the pathogenesis of organ failure in severe local and systemic infections.