tbuckley/cabot-search huggingface dataset:
Oxygen metabolism of the hypertrophic right ventricle in open chest dogs
Authors: D. Saito, H. Tani, S. Kusachi, S. Uchida, N. Ohbayashi, M. Marutani, K. Maekawa, T. Tsuji, S. Haraoka
Journal: Cardiovascular Research (1991)

The aim was to investigate oxygen metabolism of the hypertrophic right ventricle in anaesthetised open chest dogs.Right ventricular hypertrophy was induced by right ventricular pressure overload with banding the pulmonary artery for six months. Coronary blood flow and myocardial oxygen metabolism of the hypertrophic right ventricle were determined during control and after increasing right ventricular oxygen consumption, and compared with those of the normal right and left ventricles.Seven mongrel dogs with right ventricular hypertrophy and 21 normal dogs were used. All were anaesthetised with pentobarbitone sodium.Oxygen extraction [(A-V)O2] of the hypertrophic right ventricular myocardium was greater than that of normal right ventricle in controls and almost identical to the (A-V)O2 of the normal left ventricle. It showed no increase when coronary blood flow and right ventricular oxygen consumption were raised in response to a further elevation of the right ventricular pressure and isoprenaline infusion. However, the right ventricular interventions which increased right ventricular oxygen consumption produced an elevation of (A-V)O2 of the right ventricle with an increase in right coronary blood flow.Higher oxygen extraction during control and no response of oxygen extraction of the hypertrophied right ventricle in response to stimuli which increase right ventricular oxygen consumption indicate that oxygen supply to the hypertrophic right ventricle is different from that of the normal right ventricle, and is more like that of the left ventricle.
Apolipoprotein E4 allele is associated with poor treatment response in hepatitis C virus (HCV) genotype 1
Authors: Tobias Mueller, Reinhard GeΒner, Christoph Sarrazin, Carola Graf, Juliane Halangk, Heiko Witt, Eckart Köttgen, Bertram Wiedenmann, Thomas Berg
Journal: Hepatology (2003)
Cloning, characterization, and functional studies of a nonintegrin platelet receptor for type I collagen.
Authors: T M Chiang, A Rinaldy, A H Kang
Journal: Journal of Clinical Investigation (1997)

A cDNA (1.6 kb) encoding a platelet protein receptor that binds type I collagen has been isolated from a human bone marrow cDNA library by using a degenerate oligonucleotide probe derived from the amino acid sequence of a CNBr fragment of the purified receptor. Computer search revealed that this cDNA represents the coding sequence of a unique protein. Using the prokaryotic expression system pKK 223-3-65 cDNA, a 54-kD recombinant protein was obtained and purified to apparent homogeneity. In an eukaryotic expression vector (pcDNA3-65 cDNA), a 65-kD protein was identified that was recognized by monoclonal anti-65 kD antibody (anti-65m). The recombinant protein binds to type I, but not to type III collagen by affinity column chromatography. The binding of the recombinant protein to type I collagen-coated Petri dishes is inhibited by anti-65m in a dose-dependent manner. The pcDNA3-65 cDNA-transfected nonadherent T cells express the protein, allowing them to attach to a type I collagen matrix, and are inhibited by anti-65m in a dose-dependent manner. Like the receptor protein purified from platelet membranes, the recombinant protein inhibits type I collagen-induced platelet aggregation and the adhesion of [14C]serotonin-labeled platelets to type I collagen in a dose-dependent manner. The recombinant protein neither binds to type III collagen-coated Petri dishes nor inhibits type III collagen and ADP-induced platelet aggregation, indicating specificity for type I collagen.
Institutions, Contracts, and Academic Freedom
Authors: Jeffrey M. Drazen
Journal: New England Journal of Medicine (2002)

Clinical research in the United States is commonly performed under contracts between institutions and commercial sponsors. Often the investigator who actually does the research is not a direct party to the contract, but its language will govern the investigator's behavior with respect to the performance of the research. No matter how altruistic the motive, investigators must recognize that research performed under these contracts is a business transaction. It is imperative that the terms of such contracts guarantee the safety and confidentiality of patients while preserving the academic independence of participating investigators. This issue of the Journal contains several articles about . . .
BUPA and consultants over 70
Authors: A E Kark
Journal: BMJ (1992)

and to change them by using a knowledge editor.The DILEMMA project, sponsored by the European Community, entails integrating this form of logical and qualitative decision support with a general practice computer program -the Oxford Primary Care Management System.We will use it to provide decision support on prescribing, the management of chronic diseases such as asthma and hyperlipidaemia, and screening for colorectal cancer.We also intend to use this method of decision support to facilitate shared care between hospitals and general practitioners, parti-., cularly in oncology.As these systems develop they will provide mo46 flexible and sensitive decision support than those based entirely on numerical probabilities.
Bone Scintiscanning Updated
Authors: BRIAN C. LENTLE
Journal: Annals of Internal Medicine (1976)

Use of modern materials and methods has given bone scintiscanning a larger role in clinical medicine. The safety and ready availability of newer agents have led to its greater use in investigating both benign and malignant disease of bone and joint. Present evidence suggests that abnormal accumulation of 99mTc-polyphosphate and its analogues results from ionic deposition at crystal surfaces in immature bone, this process being facilitated by an increase in bone vascularity. There is, also, a component of matrix localization. These factors are in keeping with the concept that abnormal scintiscan sites represent areas of increased osteoblastic activity, although this may be an oversimplification. Increasing evidence shows that the bone scintiscan is more sensitive than conventional radiography in detecting focal disease of bone, and its ability to reflect the immediate status of bone further complements radiographic findings. The main limitation of this method relates to nonspecificity of the results obtained.
Mark Hopkins: Physician, Educator
Authors: Dana L. Farnsworth
Journal: New England Journal of Medicine (1953)

IN July, 1829, a young man of twenty-seven received his M.D. degree from the Berkshire Medical Institution in Pittsfield, Massachusetts. In a letter to his brother he stated:I have sent my dissertation for M.D. to Pittsfield, and I am glad it is the last thing of the kind I shall ever be obliged to write. I have also to pay them $15. and my tuition here, and then I shall be through with that — but as Stephen Tucker said of the beans, before you get through with one hill, another comes. I begin already to enjoy some of . . .
Martha Dorothy Faulkner Geoffrey John Myers Margaret Ormiston Nicholas David Thomas Pimm John Sholem Portnoy
Authors: J. Faulkner, A V Dunlop, G R Winter, D M Parkin, M. Pimm, D. Portnoy, B. Keane
Journal: BMJ (2000)

In 1926 she went to Manchuria as a missionary with the Irish Presbyterian Church, where she ran the mission hospital at Kirin.Her patients ranged from peasants to the family of the last emperor.In 1941 Dorothy was detained by the occupying Japanese forces and was interned, firstly in Manchuria and later in Japan, before being sent home in an exchange of civilian prisoners.In Britain she had hospital posts and then worked in singlehanded general practice in Marple, Cheshire, for 20 years.In 1965 she returned to Ulster and worked part time in general practice.When she retired she continued to be active in church life, ethical matters, charities, gardening, and environmental issues.Dorothy travelled extensively, but eschewed anything which smacked of ostentation, sometimes comparing the ways of western society unfavourably with those of her former patients in China.After a stroke in 1995 she lived in a nursing home, but returned home for three days a week to enjoy her garden and her fireside.She never married.[
A Spontaneously Arising Mutation in the DLAARN Motif of Murine ZAP-70 Abrogates Kinase Activity and Arrests Thymocyte Development
Authors: David L Wiest, Jennifer M Ashe, T.Kevin Howcroft, Hon-Man Lee, Debbie M Kemper, Izumi Negishi, Dinah S Singer, Alfred Singer, Ryo Abe
Journal: Immunity (1997)
Treatment of Resistant Herpes Simplex Virus With Continuous-Infusion Acyclovir
Authors: Jeffrey P. Engel
Journal: JAMA (1990)

Two patients with acquired immunodeficiency syndrome who developed severe ulcerative proctitis caused by herpes simplex virus type 2 that was resistant to acyclovir were successfully treated with 6 weeks of high-dose, continuous-infusion acyclovir sodium (1.5 to 2.0 mg/kg per hour). Viruses cultured from the lesions were resistant to acyclovir in vitro after the patients had received prolonged therapy with oral and intravenous acyclovir in traditional divided doses. Investigation into the mechanism of the acyclovir resistance revealed changes in the thymidine-kinase activity of both isolates. This viral enzyme phosphorylates acyclovir and is necessary for drug activation. The first patient's isolate was deficient of all thymidine-kinase activity, while the second patient's isolate had a thymidine kinase with altered substrate specificity for acyclovir. The continuous infusion was safe, well tolerated, and done in an outpatient setting with weekly clinic visits and monitoring of creatinine and acyclovir levels.
Human immunoglobulin selection associated with class switch and possible tolerogenic origins for Cδ class-switched B cells
Authors: Nai-Ying Zheng, Kenneth Wilson, Xiaojian Wang, Angela Boston, Grant Kolar, Stephen M. Jackson, Yong-Jun Liu, Virginia Pascual, J. Donald Capra, Patrick C. Wilson
Journal: Journal of Clinical Investigation (2004)

Current paradigms of peripheral B cell selection suggest that autoreactive B cells are controlled by clonal deletion, anergy, and developmental arrest. We report that changes to the human antibody repertoire likely resulting from these mechanisms both for a well-characterized autoreactivity from antibodies encoded by the VH4-34 gene and for other hallmarks of an autoreactive repertoire are apparent mainly for class-switched B cells and not for IgM germinal center, IgM memory, or IgM plasma cells. Other possible indicators of autoreactivity found selected with immunoglobulin class include JH6 gene segment usage, increased frequency of B cells with long third hypervariable regions, and distal Jκ gene segment bias. Of particular interest is the finding that B cells with these same characteristics are selected into the lineage of B cells that have undergone the unusual class switch from constant region Cμ to Cδ (Cδ-CS). The Cδ-CS population also displays an increased frequency of charged amino acids localized to the complementarity-determining regions, further suggesting autoreactivity, and evidence is presented that these B cells had undergone extensive receptor editing. Thus, the Cδ-CS lineage may be a “sink” for B cells harboring autoreactive specificities in normal humans. A model for a new tolerizing mechanism that could account for the Cδ-CS lineage is presented.
Osler as Visiting Professor: House Pupils Plus Six Skills
Authors: J. WILLIS HURST
Journal: Annals of Internal Medicine (1984)

After working with the house officers in a modern hospital for several days, Osler explains the six skills they should emphasize in their training: clinical, procedural, mental, teaching, judgmental, and managerial skills. Humaneness, he says, is expected of them and must be highly developed, especially in the modern era of high technology.
746-1 Antifibrillatory Effect of HE-93, a New K + Channel and β Adrenergic Blocker in Conscious Dogs with a Healed Myocardial Infarction
Authors: Philip B. Adamson, Stephen S. Hull, Emilio Vanoli, Yu Zuo, Robert D. Foreman, Peter J. Schwartz
Journal: Journal of the American College of Cardiology (1995)
Abstract 3050: Inducing apoptosis in mantle cell lymphoma using inhibitors of cyclin-dependent kinases and the Bcl-2 inhibitor ABT-737
Authors: Wann-Cheng Lo, David P. LeBrun, Peter A. Greer
Journal: Cancer Research (2012)

Abstract Mantle cell lymphoma (MCL) is a cyclin D1 over-expressing B cell lymphoma which displays unregulated cell cycle progression driven by increased cyclin-dependent kinase (CDK) activity. We are investigating selective small molecule CDK inhibitors as potential therapeutics in MCL. AZD5438, flavopiridol, PD-0332991 and SNS-032 have distinct efficacies against different groups of CDKs. We hypothesize that inhibiting CDK-7 and -9 will be more effective in causing cell death in MCL than inhibiting CDK-1,-2,-4 and- 6. In Jeko-1 cells, AZD5438 and flavopiridol displayed time- and dose-dependent inhibition of cell proliferation, inhibition of the phosphorylation of CDK substrates, and G1 cell cycle arrest; while PD-0332991 showed a strong cytostatic effect by inhibiting cell proliferation and arresting cells at the G1 phase, but not inducing apoptosis to the same extent as flavopiridol and AZD5438. In addition, AZD5438, flavopiridol and SNS-032 induced caspase-3 activation and down regulation of Mcl-1, but no apoptotic effect was shown in PD-0332991 treated cells. These differential effects may be associated with essential survival functions conferred by genes regulated by CDK7/9 including the pro-survival protein Mcl-1. However, there were no apoptotic effects observed with any of these CDK inhibitors in Granta-519 cells, which may due to high Bcl-2 levels. We are now exploring combinations of CDK7/9 inhibitors with a small molecule inhibitor of Bcl-2 function. We expect CDK7/9 inhibition will reduce Mcl-1 expression at the transcriptional level and thereby sensitize both Jeko-1 and Granta-519 cells to Bcl-2 inhibition. We will also investigate Mcl-1 and Bcl-2 levels in clinical samples to see if there is a correlation with outcomes. Our expectation is that Mcl-1/Bcl-2 levels may ultimately become a useful prognostic and predictive biomarker in MCL. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3050. doi:1538-7445.AM2012-3050
Review: Drugs for urgency urinary incontinence improve continence in women
Authors: Roger Dmochowski
Journal: Annals of Internal Medicine (2012)

Source Citation Shamliyan T, Wyman JF, Ramakrishnan R, Sainfort F, Kane RL. Benefits and harms of pharmacologic treatment for urinary incontinence in women: a systematic review. Ann Intern Med. 2012;156:861-74. 22711079
Successful self‐infusion of activated prothrombin complex concentrate for prophylaxis in a child with a factor VIII inhibitor
Authors: Shouichi Ohga, Akihiko Nomura, Hidetoshi Takada, Naohiro Suga, Toshiro Hara
Journal: American Journal of Hematology (2006)

Abstract Regular self‐infusion of an activated prothrombin complex concentrate (APCC) has been successfully introduced to a 14‐year‐old boy with hemophilia A. The child was diagnosed as a neonate, and at age 7 years, developed a high titer (127 BU/mL) factor VIII inhibitor coincident with a protracted ankle joint bleeding. From age 7–10 years, he received on‐demand therapy using a prothrombin complex concentrate (PCC), PROPLEX‐ST. From age 10–14 years, he received prophylaxis with PROPLEX‐ST, initiated after an intracranial hemorrhage and coincident anamnestic inhibitor response. Throughout 7‐year period of PCC treatment, he experienced recurrent bleeding episodes. Self‐prophylaxis with APCC, FEIBA VH [Anti‐inhibitor Coagulant Complex] (50 U/kg/dose three times per week) using infusion pump was initiated at 14 years of age and has continued for 2 years. There were no bleeding, thrombotic events or other adverse events after initiation of this prophylaxis, and inhibitor levels decreased to 1 BU/mL. His quality of life was improved, particularly with respect to school. Our long observation proposes a well‐disciplined home‐based FEIBA prophylaxis in inhibitor‐positive hemophiliacs. Am. J. Hematol., 2006. © 2006 Wiley‐Liss, Inc.
The Weird Divergence of Ethics and Regulation With Regard to Informed Consent
Authors: John D. Lantos
Journal: The American Journal of Bioethics (2013)

Click to increase image sizeClick to decrease image size Acknowledgments Conflict of interest: My employer, Children's Mercy Hospital (CMH), is currently a member of the NICHD Neonatal Research Network. CMH was not a member of the network at the time of the SUPPORT study. It is involved in current NICHD-sponsored studies.
Cholescintigraphy in the Diagnosis of Intrahepatic Cholestasis How Specific Is It?
Authors: WILLIAM C. KLINGENSMITH, BOYD C. ASHDOWN
Journal: Clinical Nuclear Medicine (1991)

Previous results from tests on a limited number of patients suggested that the combination of relatively normal hepatocyte clearance, prolonged parenchymal transit time, and eventual passage of radiotracer into the intestine or gallbladder without evidence of biliary tract dilatation were relatively specific for intrahepatic cholestasis. We reevaluated the specificity of cholescintigraphy for the diagnosis of intrahepatic cholestasis in an unselected group of patients from a general hospital. Sixteen patients had the cholescintigraphic findings of intrahepatic cholestasis and an established diagnosis of biliary tract dilatation or nondilatation by ultrasound, ERCP, or intraoperative cholangiography. Using 6 mm as the upper limits of normal for the diameter of the common hepatic duct by ultrasonography resulted in a specificity of 63% (10 correct out of 16); using 6 mm plus 1 mm for for every decade over 60 years of age gave a specificity of 75% (12 correct out of 16); and using the more liberal criterion of 8 mm as the upper limits of normal increased the specificity to 81% (13 out of 16). The data suggest that cholescintigraphy alone is unreliable in differentiating intrahepatic cholestasis from extrahepatic obstruction, even when the obstruction is partial and radiotracer eventually passes through the extrahepatic biliary tract.
At long last: An animal model of Wilson's disease Mori M, Hattori A, Sawaki M, Tsuzuki N, Sawada N, Oyamada M, Sugawara N, Enomoto K. The LEC rat: a model for human hepatitis, liver cancer and much more. Am J Pathol 1994;144:200–204
Authors: R Sokol
Journal: Hepatology (1994)
Diagnosis, management, and prevention of rotavirus gastroenteritis in children
Authors: U. D. Parashar, E. A. S. Nelson, G. Kang
Journal: BMJ (2013)

<h3>Background</h3> Myotonic Dsytrophy (DM) is a multi-system disease that affects muscle function. DM is the most common muscular dystrophy occurring in adulthood and the prevalence is around 10 cases per 100,000. There are two distinct forms Type 1 and Type 2. DM predominantly causes weakness of the voluntary muscles but involuntary muscles can also be affected. As the disease progresses respiratory, cardiac and gastrointestinal symptoms can arise. Despite treatment options for management of complications, DM remains a progressive life limiting condition. Severn Hospice is now affiliated with Robert Jones Agnes Hunt Hospital in Oswestry to provide a symptom control clinic for DM patients; something that is not routinely done nationally. Palliative Care should be involved early in the diagnosis to allow more effective symptom control and discussions around Advance Care Planning. <h3>Methods &amp; Results</h3> We collated the data for the 5 patients with a DM diagnosis that were referred to Severn Hospice and/or joint symptom control clinics. All 5 patients were assessed for symptoms that included but were not limited to: breathlessness, pain, dysphagia and low mood. 3/5 patients are still alive and have ongoing support. We coordinated referrals to other specialities including PEG/Respiratory teams for ongoing assessment. 1 patient was admitted to the inpatient unit which allowed for symptoms to be optimised and Advance Care Planning to occur. <h3>Conclusions</h3> The role of Palliative Care in the management of DM patients is paramount and early involvement in the disease trajectory is optimal for improving symptom control and providing opportunities for advance care planning relating to specific complications, e.g. cardiac arrhythmias/feeding tube insertion/respiratory support. Clinical guidelines for the role of Palliative Care in DM are limited, despite the fact it is a life limiting illness. This has prompted a focus group who are looking to put together some National Guidance moving forwards.
Stroke Prevention
Authors: James F. Toole, David C. Sane, Kerstin Bettermann
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Extrahepatic portal venous obstruction.
Authors: J B Dilawari, Y K Chawla
Journal: Gut (1988)

question of how continence was maintained.A technique similar to that adopted in urodynamics was used.Rectal and anal canal pressures were measured together with puborectalis and external anal sphincter electromyogram whilst the subject carried out a Valsalva manoeuvre.The rectum was filled with a dilute barium solution until a sensation of fullness was perceived.During the Valsalva manoeuvre the rectum was visualised radiologically whilst measure- ments were made.We have now carried out over 50 such examinations and never observed a flap valve occlusion of the upper anal canal.Indeed the anterior rectal wall was always clearly separated from the top of the anal canal.Moreover rectal pressures never exceeded anal canal pressures.The conclusions of our study reported in the British Journal of Surgery3 were similar to those of Bannister et all -namely, that continence is maintained by sphincteric means.
SAFETY PIN SAFELY PASSED BY A CHILD OF ELEVEN MONTHS.
Authors: L. W. LITTIG
Journal: JAMA (1905)

On October 19, Dr. W. D. Phillips, Victor, Iowa, consulted me regarding an 11-months-old baby who had accidentally swallowed an open safety pin, one and one-eighth inches in length. I was inclined to locate the pin with the x-ray and to at once remove, if seen in the stomach, but it was decided to wait for trouble and then to operate without delay. On October 24, a few hours less than five days after the pin had been swallowed, it was passed by the child. No inconvenience at all was suffered and no special treatment was given. The parents lived in the country, and did not bring the child for x-ray examination; hence, there was no opportunity to observe the progress of the pin through the intestine.