tbuckley/cabot-search huggingface dataset:
Letter: Withdrawal symptoms after stopping phenelzine?
Authors: B Pitt
Journal: BMJ (1974)

prednisolone twice daily.At no time did he receive any sulphonamide preparation.While on this dosage of prednisolone he re- ceived, in October 1973, an injection of 1 ml of Admune subcutaneously, which he had had in the previous year.Within 10 days he began to suffer from myalgia, which affected all muscle groups, and arthralgia.His weight began to fall and this was asso- ciated with general malaise and anorexia.Clinical examination was unhelpful apart from a maintained pyrexia of 38-39°C and generalized muscle wasting.Investigations showed a haemoglobin of 11-0 g/100 ml; E.S.R. 33 mm in 1 hr; serum electrolytes and urea normal; W.B.C. 22,000/mm3 with 6,300 eosinophils/mm'; serum creatinine phosphokinase 17 mU/ml; antinuclear factor negative; L.E. cells not seen.Both latex and Rose-Waaler tests were weakly positive.Urine contained protein 10 mg/100 ml, but no blood at any time.His blood urea then rose to 74 mg/100 ml and alkaline phos- phatase to 22 King-Armstrong units.Serum asparate aminotransferase was 44 IU/1.and serum hydroxybutyric acid dehydrogenase 36 IU/1.Pro- tein electrophoresis showed a low albumin level with increased a2-globulin.An electromyograph showed small motor units consistent with myo- pathy.Muscle biopsy was performed and this showed necrotizing arteritis.Tests for antinuclear factor then became positive but serum complement was 132 mg/100 ml (normal 82-150 mg/100 Ml).He was started on 40 mg of prednisolone daily and made good symptomatic improve-
Abstract P4-12-12: Phase 2, multicenter, single-arm study of eribulin mesylate + trastuzumab as first-line therapy for locally recurrent or metastatic HER2-positive breast cancer
Authors: S Wilks, S Puhalla, J O'Shaughnessy, L Schwartzberg, E Berrak, J Song, J Rege, D Cox, L Vahdat
Journal: Cancer Research (2013)

Abstract Background: Eribulin mesylate, a non-taxane microtubule dynamics inhibitor, has been approved for patients with metastatic breast cancer (MBC) who have previously received ≥2 chemotherapeutic regimens for MBC. We present final data from a phase 2 study that evaluated efficacy and safety of eribulin + trastuzumab as first-line therapy for locally recurrent or metastatic human epidermal growth factor receptor 2 positive (HER2+) BC. Methods: Patients received eribulin mesylate at 1.4 mg/m2 IV on days 1 and 8 of each 21-day cycle and an initial trastuzumab dose of 8 mg/kg IV on day 1, followed by 6 mg/kg on day 1 of each subsequent cycle. Endpoints include objective response rate (ORR), safety, progression-free survival (PFS), time to response (TTR), and duration of response (DOR). Tumor assessments were conducted every 6 weeks for the first 6 cycles and every 6-12 weeks thereafter per RECIST 1.1. Results: Fifty-two patients with a median age of 60 years (range 31- 81) were treated; 96% had stage IV disease, 73% had visceral disease, and 48% had liver metastases. Thirty one patients had prior neo/adjuvant chemotherapy (11 had prior anthracycline, and 22 had prior taxane). Patients received a median of 10(0, 33) cycles of eribulin and 11(1, 31) cycles of trastuzumab. ORR was 67% with median TTR of 1.3 months and PFS of 11.5 months (Table). The most common (&amp;gt;5%) Grade 3/4 treatment related treatment emergent (TRTE) AEs were neutropenia (n = 20; 38.5%), peripheral neuropathy (n = 14; 26.9%) and febrile neutropenia (n = 4; 7.7%). Serious TRTE AEs occurred in 14 patients and included neutropenia (n = 9; 17.3%), febrile neutropenia (n = 4; 7.7%), and peripheral neuropathy (n = 3; 5.8%). Reasons for discontinuation were AEs (n = 7) and PD (n = 22). Table. Summary of Efficacy EndpointsEfficacy EndpointsEribulin/Trastuzumab N = 52Objective Response Rate, n (%)35 (67)- Complete Response (CR)2 (4)- Partial Response (PR)33 (64)Stable Disease (SD)15 (29)Progressive Disease (PD)1 (2)Not Evaluable1 (2)Overall Clinical Benefit Rate, n (%)42 (81)Time to First Objective Response, median months (95% CI)1.3 (1.2, 1.4)Duration of Objective Response, median months (95% CI)a11.1 (6.5, 17.8)Progression-Free Survival, median months (95% CI)11.5 (7.3, 13.5)Duration of Stable Disease, median months (95% CI)7.1 (5.2, 13.5)Clinical Benefit Rate = ORR+ ≥6 mo SD; an = 35 Conclusions: This study suggests that the combination of eribulin + trastuzumab first-line therapy for locally recurrent or metastatic HER2+ BC has an acceptable safety profile and results in considerable tumor response with a long DOR. Additional larger studies with this combination are warranted. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P4-12-12.
THE QUESTION OF OPERATION IN GUNSHOT ABDOMINAL WOUNDS
Authors: JOSEPH RILUS EASTMAN
Journal: JAMA (1918)

The study of gunshot wounds of the abdomen deals with one of the most interesting chapters of the major wounds of war, especially by reason of the numerous controversies relating to a general plan of treatment of abdominal wounds. Certainly the present war has developed important advances in this department of surgery. In previous wars it was held as dogma that gunshot wounds of the abdomen should be treated expectantly and conservatively, as distinguished from the teaching of prompt operation in civil practice. At the present time, it may be said that the weight of opinion is in favor of applying in military practice the civil method of immediate operation in all penetrating wounds of the abdomen wherever the favorable conditions of civil practice can be provided. These essential conditions include a skilled operator, trained assistants, a sufficient armamentarium, an aseptic environment, and the time in which to operate. Practically
ALCOHOL AS A FACTOR IN THE CAUSATION OF PULMONARY CONSUMPTION.
Authors: THOMAS J. MAYS
Journal: JAMA (1907)

lessened power of resistance to the vasoparalytic and direct toxic effects of alcohol.One hundred and two children in twenty-five families of heavy drinking parents show the following: Seven had tuberculosis, 8 had diseases of the heart, 31 had functional diseases of the nervous system, 41 were drink- ers, 6 were degenerates and 4 were idiots.Only 5 of the entire number were normal.In moderate drinkers alcohol produces a modification of function in the highly organized nervous elements.
BPA and Insulin Resistance: Evidence of Effects in Dams and Offspring
Authors: M. Nathaniel Mead
Journal: Environmental Health Perspectives (2010)

Research in China Assesses ExposuresHuman activities such as mining, smelting, and coal combustion dis perse mercury that can be methylated by bacteria to produce methyl mercury, a potent neurotoxicant.Methylating bacteria thrive in aquatic sediments rich in organic matter, and methylmercury biomagnification eventually leads to heavy contamination of top predators, including fish consumed by humans.Although fish and seafood are the most common dietary sources of methylmercury worldwide, new research from China demonstrates that rice, a staple food for billions, can be a primary source of methylmercury in areas where there is substantial inorganic mercury pollution, with calculated exposure exceeding cur rent tolerable daily intakes [EHP 118( 9):1183-1188; Zhang et al.].The research was conducted in four regions in Guizhou province, an area of inland China with rich deposits of cinnabar (a mercury ore).Mercury mining and smelting have led to heavy pollution in Wanshan, while zinc smelting and coal combustion, which also release mercury, are the main contributors in Weining and Qingzhen, respectively.The fourth region, Leigong, is a remote nature reserve selected to represent an area with no sources of direct mercury contamination.Methylmercury and total mercury exposure through drinking water, diet, and respiration were assessed for adults in the four regions.Previous sampling provided data for air, water, fish, meat, and poultry, while agricultural products (rice, corn, and vegetables), drinking water from Wanshan and Leigong, and total gaseous mercury in Wanshan were newly evaluated in this study.These data were collectively used to calculate probable daily intakes for the general adult population.In all regions rice, vegetables, and meat (not including poultry and fish) accounted for 89-97% of total mercury exposure, whereas rice consumption accounted for 94-96% of methylmercury exposure.Fish contributed little; most of the fish consumed here are farmed species that grow rapidly and eat a diet that precludes significant methyl mercury bioaccumulation.
KATP channels in ischaemic preconditioning
Authors: J. R Parratt, K. A Kane
Journal: Cardiovascular Research (1994)

Journal Article KATP channels in ischaemic preconditioning Get access James R Parratt, James R Parratt Cardiovascular Research, Department of Physiology and Pharmacology, University of Strathclyde, Royal College, 204 George St, Glasgow G1 lXW, United Kingdom: J R Parratt, K A Kane. Correspondence to Professor Parratt. Search for other works by this author on: Oxford Academic PubMed Google Scholar Kathleen A Kane Kathleen A Kane Cardiovascular Research, Department of Physiology and Pharmacology, University of Strathclyde, Royal College, 204 George St, Glasgow G1 lXW, United Kingdom: J R Parratt, K A Kane. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 6, June 1994, Pages 783–787, https://doi.org/10.1093/cvr/28.6.783 Published: 01 June 1994 Article history Received: 24 January 1994 Accepted: 07 March 1994 Published: 01 June 1994
VII European Paediatric Rheumatology Congress: Annual Scientific Meeting of PRES
Authors: M. HOFER
Journal: Annals of the Rheumatic Diseases (2000)

We used a highly sensitive molecular heteroduplex technique to track specific clonality of TCR expressed by synovial T cells from children with JIA. 1 We observed nonoverlapping oligoclonality compared with peripheral T cells, with large clonal expansions which may be identical in diVerent joints and persist over several years.Although synovial T cells have a highly activated phenotype (mostly CD45RO+ and HLA-DR+), we showed that the oligoclonal patterns diVer from CD45RO+ cells in peripheral T cells.We also showed that dominant synovial T cell clones from children with oligoarticular JIA are in the CD4+ population, whereas in children with HLA-B27+ (enthesitis-related) arthritis large T cell clones dominate in the CD8+ population.Sequencing and reanalysing the whole TCR repertoire with N-region-specific sequences confirmed that these clones are at a very low frequency (less than 1 in 50 000 cells) in peripheral blood.This unexpected divergence is now being investigated at the level of antigen-specific T cells using major histocompatibility complex/peptide tetramers.
Cervical carotid or vertebral artery dissection
Authors: S. B Blunt, C. Galton
Journal: BMJ (1997)

Background: Hepatocyte growth factor activator inhibitor type-1 (HAI-1) inhibits hepatocyte growth factor activator and matriptase. In the present study it was investigated whether the expression of HAI-1 is associated with the progression of prostate cancer. Patients and Methods: The expression of HAI-1 was evaluated by immunohistochemistry (IHC) of samples from 51 patients with negative prostate biopsies and 75 patients with untreated prostate cancer. Furthermore, the expression of HAI-1 was evaluated in 24 patients with castration-resistant prostate cancer (CRPC), and the relationship between HAI-1 expression and the prostate-specific antigen (PSA) progression-free rate was investigated. Results: Expression of HAI-1 by IHC in patients with prostate cancer was significantly higher than in those with negative prostate biopsy. CRPC exhibited significantly lower HAI-1 expression than untreated metastatic prostate cancer. The PSA progression-free rate was worse in patients without HAI-1 expression than in those with positive HAI-1 expression. Conclusion: It is suggested that HAI-1 may play an important role in the pathogenesis of CRPC.
Topical nitroprusside may reduce histamine‐induced plasma exudation in human nasal airways
Authors: L. Greiff, M. Andersson, C. Svensson, M. Nilsson, I. Erjefält, J. S. Erjefält, C. G. A. Persson
Journal: Allergy (1995)

Mucosal exudation of nonsieved bulk plasma is a key feature of airway defense and inflammation. We have previously observed in guinea pig tracheobronchial airways that endogenous nitric oxide (NO) of the mucosa may tonically suppress the permeability of the subepithelial microcirculation, and that topical administration of the NO donor nitroprusside may reduce plasma exudation responses. The present study examines whether nitroprusside affects histamine‐induced mucosal exudation of plasma in the human nasal airway. In a dose‐finding tolerability experiment, using changes in nasal patency as response, placebo and nitroprusside (1.2 and 3.6 mg per nasal cavity) were applied on the mucosal surface with a nasal‐spray device. Nasal peak expiratory flow (PEF) rates were measured before the application and thereafter every third minute for 15 min. Nitroprusside produced a dose‐dependent decrease in nasal PEF rates compared to placebo. Placebo or nitroprusside (7.2 mg) was then given to the right nasal cavity, followed 3 min later by challenge with saline or histamine (600 μg). The drug and the challenge were both applied with a nasal‐spray device. With a nasal pool‐device, the same large part of the nasal mucosal surface was lavaged before and after the treatment/challenge. The lavage fluid levels of a2‐macroglobulin were measured as an index of mucosal exudation of bulk plasma. The histamine‐induced lavage fluid level of aj‐macroglobulin was significantly higher after treatment with placebo than with nitroprusside. The present data indicate that nitroprusside may have antiexudative effects in human airways. Hence, unlike other microvascular permeability active agents, this pharmacologic principle may be active in both guinea pig and human airways.
Cytophotometric and flow cytometric DNA content of isolated glands in gastric neoplasia.
Authors: Y Kitayama, S Nakamura, H Sugimura, I Kino
Journal: Gut (1995)

The gland isolation method was applied to various gastric lesions to measure DNA content by cytophotometry and flow cytometry for the first time. By incubating and agitating fresh specimens from surgically resected stomachs in calcium-magnesium free Hanks's balanced salt solution (CMFH) containing EDTA, many neoplastic glandular epithelial cells were successfully isolated from the stroma, and their characteristic three dimensional features were seen morphologically. The DNA content of pure nuclear suspensions of isolated glands was obtained by cytophotometry and flow cytometry staining with 4',6-diamino-2-phenylindole dihydrochloride (DAPI) and propidium iodide, respectively. Compared with histological grading, the frequency of the DNA aneuploidy of cancer with moderate or poor differentiation by cytophotometry (75%) was significantly higher than that of well differentiated cancer (25%), but the histological typing of gastric cancer DNA frequency were not correlated. This method allowed us to detect small aneuploid peaks by flow cytometry, which were previously masked by contaminating interstitial cells. The frequency of DNA aneuploidy detected by flow cytometry (87.5%) was higher than detected by cytophotometry (58.3%). The results of these studies shows the feasibility of this technique for analysing the DNA content of various lesions of the stomach.
Circulation Time in the Aged-Reply
Authors: Gerald A. Diettert
Journal: JAMA (1963)

I do not find Dr. Levy's results inconsistent with values which I obtained in my study. Values for the circulation time fall in a range distributed along a frequency curve. The mean value will be somewhat dependent upon the number of cases studied. The upper value for normal has been variously quoted from 16 sec by Tarr and his associates (<i>Amer Heart J</i><b>8</b>:766, 1933) to 20.8 by Lubic and his associates (<i>Amer Heart J</i><b>44</b>:443, 1962). Some of Dr. Levy's elderly patients also exceed this quoted upper limit of normal. The circulation time is related to volume of circulating blood and the cardiac output and will increase if the blood volume increases or the cardiac output falls. It could also increase if there was a local slowing of blood velocity in one or more segments of the circulation pathway reflected then in the total circulation time. A
Recording of intstinal motility: routine or research?
Authors: A M Connell
Journal: Gut (1967)

Recording of intestinal motility: routine or research?In 1899 Bayliss and Starling wrote: 'On no subject in physiology do we meet with so many dis- crepancies of fact and opinion as in that of the physiology of the intestinal movements.'Regrettably, this remains valid today.The methods that can be used for the routine study of the movements of the alimentary tract in man are radiologyand manometry, but they offer only circumstantial evidence about events occurring in the muscle itself.
Tangentially Migrating Neurons Assemble a Primary Cilium that Promotes Their Reorientation to the Cortical Plate
Authors: Jean-Pierre Baudoin, Lucie Viou, Pierre-Serge Launay, Camilla Luccardini, Sergio Espeso Gil, Vera Kiyasova, Théano Irinopoulou, Chantal Alvarez, Jean-Paul Rio, Thomas Boudier, Jean-Pierre Lechaire, Nicoletta Kessaris, Nathalie Spassky, Christine Métin
Journal: Neuron (2012)
Hepatitis C viral protein NS5A induces EMT and participates in oncogenic transformation of primary hepatocyte precursors
Authors: Leila Akkari, Damien Grégoire, Nicolas Floc’h, Marie Moreau, Céline Hernandez, Yannick Simonin, Arielle R. Rosenberg, Patrice Lassus, Urszula Hibner
Journal: Journal of Hepatology (2012)
Identification of Peptide Vaccine Candidates Sharing among HLA-A3+, -A11+, -A31+, and -A33+ Cancer Patients
Authors: Hiroko Takedatsu, Shigeki Shichijo, Kazuko Katagiri, Hiromi Sawamizu, Michio Sata, Kyogo Itoh
Journal: Clinical Cancer Research (2004)

Abstract Purpose: Only a few studies have been reported on CTL epitope peptides restricted with alleles other than HLA-A2 and -A24. The HLA-A11, -A31, and -A33 alleles share similar binding motifs with HLA-A3 and -A68 alleles, and, thus, are classified as an HLA-A3 supertype. This study tried to identify CTL epitope peptides as vaccine candidates sharing by HLA-A3+, -A11+, -A31+, and -A33+ cancer patients. Experimental Design: Seven peptides possessing the ability to induce HLA-A31-restricted and tumor-reactive CTLs were examined for their ability to induce HLA-A3-, -A11-, and -A33-restricted and tumor-reactive CTLs from peripheral blood mononuclear cells (PBMCs) of 18 epithelial cancer patients. The five reference peptides all have the ability to induce CTL activity restricted with one of the HLA-A3 supertypes, and, thus, were also examined as positive controls. Results: Three peptides (2 from β-tublin5- and 1 from CGI37-derived peptides) induced tumor-reactive CTLs in PBMCs of HLA-A3+, -A11+, and -A33+ cancer patients with various frequencies (17–50%). One RLI- or KIAA0036-derived peptide induced tumor-reactive CTLs in PBMCs of HLA-A3+ and -A11+ or HLA-A11+ and -A33+ cancer patients also with various frequencies (22–67%), respectively, whereas the other peptide induced CTL activity in only HLA-A33+ patients. Among the five reference peptides tested, one peptide, TRP2–197, induced CTL activity in both HLA-A11+- and -A33+-restricted manners. Conclusions: We identified new peptide vaccine candidates for HLA-A3, -A11, -A31, and -A33 positive cancer patients. This study may facilitate the development of both basic and clinical studies of peptide-based immunotherapy for cancer patients with other alleles of HLA-A2 and -A24.
X-Linked Mental Retardation and an X-Chromosome Marker
Authors: Park S. Gerald
Journal: New England Journal of Medicine (1980)

This issue of the Journal contains an article by Turner and her colleagues that presents yet another chapter in the rapidly expanding saga of the relation between mental retardation and a cytogenetically detectable change in the X chromosome. The story begins with Penrose's report in 1938 of an excess of males among persons who are institutionalized because of mental retardation.1 The excess has been repeatedly confirmed since then and has been shown to be quite large: there are often 30 to 50 per cent more men than women. In 1974, Gillian Turner and her husband examined the records of all . . .
Ultrasound-Guided Extracorporeal Shock Wave Therapy for Plantar Fasciitis
Authors: Rachelle Buchbinder, Ronnie Ptasznik, Jeanine Gordon, Joylene Buchanan, Vasuki Prabaharan, Andrew Forbes
Journal: JAMA (2002)

Context Extracorporeal shock wave therapy (ESWT) is increasingly used for plantar fasciitis, but limited evidence supports its use.Objective To determine whether ultrasound-guided ESWT reduces pain and improves function in patients with plantar fasciitis.Design Double-blind, randomized, placebo-controlled trial conducted between April 1999 and June 2001.Setting Participants were recruited from the community-based referring physicians (primary care physicians, rheumatologists, orthopedic surgeons, and sports physicians) of a radiology group in Melbourne, Australia. ParticipantsWe screened 178 patients and enrolled 166; 160 completed the 15week protocol.Entry criteria included age at least 18 years with plantar fasciitis, defined as heel pain maximal over the plantar aspect of the foot of at least 6 weeks' duration, and an ultrasound-confirmed lesion, defined as thickening of the origin of the plantar fascia of at least 4 mm, hypoechogenicity, and alterations in the normal fibrillary pattern.Interventions Patients were randomly assigned to receive either ultrasoundguided ESWT given weekly for 3 weeks to a total dose of at least 1000 mJ/mm 2 (n=81), or identical placebo to a total dose of 6.0 mJ/mm 2 (n=85). Main Outcome MeasuresOverall, morning, and activity pain, measured on a visual analog scale; Maryland Foot Score; walking ability; Short-Form-36 Health Survey (SF-36) score; and Problem Elicitation Technique score, measured at 6 and 12 weeks after treatment completion.Results At 6 and 12 weeks, there were significant improvements in overall pain in both the active group and placebo group (mean [SD] improvement, 18.1 [30.6] and 19.8 [33.7] at 6 weeks [P=.74 for between-group difference], and 26.3 [34.8] and 25.7 [34.9] at 12 weeks [P=.99], respectively).Similar improvements in both groups were also observed for morning and activity pain, walking ability, Maryland Foot Score, Problem Elicitation Technique, and SF-36.There were no statistically significant differences in the degree of improvement between treatment groups for any measured outcomes. ConclusionWe found no evidence to support a beneficial effect on pain, function, and quality of life of ultrasound-guided ESWT over placebo in patients with ultrasoundproven plantar fasciitis 6 and 12 weeks following treatment.
Recent Advances in Thrombosis
Authors: Robert T. Breckenridge
Journal: JAMA (1974)

This volume is intended to complement the<i>Recent Advances in Blood Coagulation</i>. Once again, Dr. Poller has assembled a panel of experts and has done an excellent job coordinating their various contributions. The first article is an overview of thrombosis and thrombosis research by Dr. Owren, followed by a section devoted to the epidemiology, diagnosis, pathology, and treatment of venous thrombotic disease. Subsequently, Fletcher and Alkaersig discuss the laboratory diagnosis of intravascular coagulation with special emphasis on their procedures for its detection. Platelet physiology, and the role of the platelet in thrombosis, is then followed by a discussion of fibrinolytic therapy. The concluding sections of the book deal with oral contraceptives and clinical thrombosis, and a discussion of the immunological and molecular characteristics of fibrinogen and fibrin cleavage fragments. The opening section is superb. Dr. Owren has synthesized a complicated, rapidly expanding field into a cohesive concept. Unfortunately, the second