tbuckley/cabot-search huggingface dataset:
Rosetting of activated human T lymphocytes with autologous erythrocytes. Definition of the receptor and ligand molecules as CD2 and lymphocyte function-associated antigen 3 (LFA-3).
Authors: M L Plunkett, M E Sanders, P Selvaraj, M L Dustin, T A Springer
Journal: The Journal of Experimental Medicine (1987)

CD2, also known as LFA-2, T11, and the E rosette receptor, is a T lymphocyte surface protein functionally important in adhesion to target cells and T cell triggering. LFA-3 is a widely distributed cell surface protein that functions in adhesion on target cells. We find that LFA-3 is expressed on human E, and that CD2 is a receptor for LFA-3 that mediates T cell adhesion to human E. Pretreatment of T lymphocytes with CD2 mAb or of E with LFA-3 mAb inhibits rosetting. Purified CD2 molecules bind to human E and inhibit rosetting. 125I-CD2 binding to E is inhibited by LFA-3 mAb; reciprocally, binding of LFA-3 mAb to human E is inhibited by pretreatment with purified CD2. Higher concentrations of CD2 aggregate human E; aggregation is inhibited by mAb to LFA-3.
SOME OF THE SOCIAL PROBLEMS OF MEDICINE
Authors: WILLIAM ALLEN PUSEY
Journal: JAMA (1924)

My wife has a saying, that the other side of the street is always the cleanest—meaning thereby to illustrate the fact that we are less acutely conscious of difficulties at a distance than we are of those directly under our feet. This is true of other things besides sidewalks. The freedom from cares of youth, the good old times; the ease of life of other days, the extraordinary anxieties of our intense civilization, the perfection of our heroes, whether they are separated from us by time or distance —provided only they are separated from us; these are common illustrations of the kind illusions that distance effects. Most of us have a feeling that we have more than our share of difficulties. And so it is with medicine. As a matter of fact, of course, medicine—like every other activity of civilized life—has always had its problems. It is perhaps true, therefore,
Electrocardiographic Training in Primary Care Residency Programs
Authors: Ronald E. Pinkerton
Journal: JAMA (1981)

To evaluate ECT interpretation in physicians training for primary care, we tested residents in two residency programs (one internal medicine, one family medicine) for their ability to interpret ECGs produced in an ambulatory practice. An 18-item examination used abnormal tracings from a university hospital ambulatory unit, including six technical problems generated in the daily operation of the unit. Ability increased with advancing graduate level; however, performance for both internal medicine and family medicine residents fell short of the expected level. Residents completing training in both programs incorrectly interpreted many of the technical problems (eg, limb lead reversal) as well as the usual ECG diagnoses (eg, acute pericarditis). This study suggests that ECG training of primary care residents should be supplemented to meet specific needs of the ambulatory component of primary care practice.
IS MEMBRANOUS CROUP DIPHTHERIA?Read before the Indiana State Medical Society at Indianapolis, May 17, 1894.
Authors: FREDERICK C. WOODBURN
Journal: JAMA (1894)

Notwithstanding the investigations which this question has provoked during the last decade, there is still quite a diversity of opinion concerning the identity of these two affections, and considerable time must yet elapse ere a positive answer may be given to the query which forms the title of this paper. The desire of the writer is to stimulate an interest upon this subject in the Society, and to bring about a thorough discussion upon it, believing, as he does, that a free interchange of ideas and experiences is one method by which an elucidation of the problem may be brought about. In the past few years the bacteriologist and microscopist have stepped prominently to the foreground, and to their indefatigable labors and their valuable investigations and experimentation are we indebted for the marvelously rapid strides forward which medical science has taken. Our ideas of the etiology of disease have radically
Death becomes us
Authors: J. Clark
Journal: BMJ (2003)

According to www.deathclock.com I will die on Tuesday 14 March 2051. At the time of writing that translates to 1 504 875 429 seconds left of living. But when my time comes will I die the death I want?

Perhaps the best way to die is to do so in a way that leaves the possibility of living again. Arrangements can be made at the Alcor Life Preservation Foundation (www.alcor.org) to cryopreserve your body—that is, to freeze it in liquid nitrogen for future resurrection. Once medical technology catches up, proponents of cryonics claim, it may be possible to have your suspended body revived, the cause of your death cured, and your aged and damaged cells repaired. Cryonics is touted as an extended form of artificial resuscitation: you wouldn't deny a paramedic resuscitating your heart after it stops beating, would you?

For those curious about death and the funeral industry, www.msprozac.zoovy.com (which is run by a webmaster battling advanced …
1080-63 The real-world clinical practice of intracoronary radiation therapy as compared to investigational trials
Authors: Seung-Woon Rha, Pramod K Kuchulakanti, Maureen C Abbott, Katrina Barksdale, Ellen Pinnow, Rebecca Torguson, Michael Porrazzo, William O Suddath, Augusto D Pichard, Lowell F Satler, Kenneth K Kent, Ron Waksman
Journal: Journal of the American College of Cardiology (2004)
Contribution of histamine and prostanoids to bronchoconstriction provoked by inhaled bradykinin in atopic asthma
Authors: R. Polosa, G. D. Phillips, C. K. W. Lai, S. T. Holgate
Journal: Allergy (1990)

Bradykinin, a nonapeptide cleavage product of high molecular weight kininogen, is a potent bronchoconstrictor agonist in asthma; however, its mechanism of action is not known. Since bradykinin has been shown to stimulate mediator release from mast cells and augment the release of prostanoids, we have examined the effect of a selective histamine H1 receptor antagonist, terfenadine and a potent cyclooxygenase inhibitor, flurbiprofen on bronchoconstriction provoked by inhaled bradykinin in asthma. As a bronchial provocation procedure bradykinin challenge was repeatable to within 1 doubling dilution. In nine atopic asthmatic subjects, terfenadine 180 mg, when compared to placebo, increased the geometric mean provocation concentration of inhaled agonist required to reduce FEV1 by 20% of baseline (PC20) from 0.7 to greater than 22.9 mg/ml for histamine (P less than 0.01) and 0.3 to 0.5 mg/ml for bradykinin (P less than 0.01). In a further nine atopic asthmatics, flurbiprofen 150 mg when compared to placebo produced a small but significant protection of the airways against bradykinin, geometric mean PC20 increasing from 0.40 to 0.79 mg/ml (P less than 0.05). We conclude that bradykinin is a potent bronchoconstrictor agonist in asthma, being approximately 9.5 times more potent than histamine in molar terms. Pharmacological intervention with terfenadine and flurbiprofen led to a significant protection of the airways against the constrictor effect of bradykinin but the effect in each case was small. Thus, while histamine and prostanoids may contribute as mediators of bradykinin-induced bronchoconstriction, they are unlikely to account for the majority of the response.
Vomiting of Neurologic Origin
Authors: J C García-Moncó, J A Larena
Journal: New England Journal of Medicine (2001)

Figure 1. A 25-year-old man had a seven-month history of repeated, unprovoked, sudden vomiting without accompanying headache or any other neurologic or gastrointestinal symptoms. Vomiting had occurred daily in the previous two months. The results of a neurologic and general examination were normal, and there was no papilledema. A contrast-enhanced T1-weighted sagittal magnetic resonance image of the brain showed an intensely enhancing mass in the inferior region of the fourth ventricle, with mild ventricular enlargement (arrow). Other images showed focal invasion of the brain stem with moderate edema. The mass — a choroid-plexus carcinoma — was removed surgically, . . .
Endoscopic Management of Acute Gastric Anisakiasis
Authors: Y. Akasaka, M. Kizu, A. Aoike, K. Kawai
Journal: Endoscopy (1979)

Early endoscopy was performed in six cases of acute gastric anisakiasis. Immediately after detecting the larva of anisakis, the larval body was extracted together with its surrounding mucosa by a biopsy forceps. With the removal of the larva, severe colic pain subsided rapidly. Two cases in our series were identified as the stage IV larvae of the anisakis, type I. It was presumed that the stage III larva had exuviated in the human stomach. It is emphasized that endoscopic extraction of larva is the most effective procedure in dealing with acute gastric anisakiasis.
Evaluating pandemic risk
Authors: Susan Chu
Journal: BMJ (2007)

Delamothe asks why we should be any more worried about pandemic flu in 2007 than in 1997 or 2017.1 There are certain observable biological events (such as repeated human infections by a novel avian virus) that are potential precursors to a pandemic and may give us some warning of what might be imminent, a luxury that previous generations did …
The Ballistocardiogram in Mitral Stenosis
Authors: F. W. DAVIS, WM. R. SCARBOROUGH, R. E. MASON, M. L. SINGEWALD, B. M. BAKER, SALLE A. LORE, HELEN TRANDES, MADELON MENZIES
Journal: Circulation (1953)

The ballistocardiograms of 13 of 14 patients with "pure" mitral stenosis were found to show acharacteristic late diastolic and early systolic deformity. The deformity consists of a footward wave which precedes the I wave, often resulting in "doubling" of the I, or fusion with the I, producing a wide, deformed wave. Ballistocardiograms of patients with mitral insufficiency did not consistently show this deformity. Immediately after commissurotomy this abnormality was diminished, but was not completely eliminated. Some possible factors concerned in the genesis of this pattern are discussed.
Genome-wide response of the human Hep3B hepatoma cell to proinflammatory cytokines, from transcription to translation
Authors: Cédric Coulouarn, Grégory Lefebvre, Romain Daveau, Franck Letellier, Martine Hiron, Laurent Drouot, Maryvonne Daveau, Jean-Philippe Salier
Journal: Hepatology (2005)

Abstract Given the unknown timing of the onset of an acute systemic inflammation in humans, the fine tuning of cascades and pathways involved in the associated hepatocyte response cannot be appraised in vivo . Therefore, the authors used a genome-wide and kinetic analysis in the human Hep3B hepatoma cell line challenged with a conditioned medium from bacterial lipopolysaccharide-stimulated macrophages. A complete coverage of the liver transcriptome disclosed 648 mRNAs whose change in abundance allowed for their clustering in mRNA subsets with an early, intermediate, or late regulation. The contribution of transcription, stability, or translation was appraised with genome-wide studies of the changes in nuclear primary transcripts, mRNA decay, or polysome-associated mRNAs. A predominance of mRNAs with decreased stability and the fact that translation alone controls a significant number of acute phase–associated proteins are prominent findings. Transcription and stability act independently or, more rarely, cooperate or even counteract in a gene-by-gene manner, which results in a unidirectional change in mRNA abundance. Waves of mRNAs for groups of functionally related proteins are up- or downregulated in an ordered fashion. This includes an early regulation of transcription-associated proteins, an intermediate repression of detoxication and metabolism proteins, and finally an enhanced translation and transport of a number of membranous or secreted proteins along with an enhanced protein degradation. In conclusion , this study provides a comprehensive and simultaneous overview of events in the human hepatocyte during the inflammatory acute phase. Supplementary material for this article can be found on the H epatology website ( http://www.interscience.wiley.com/jpages/0270-9139/suppmat/index.html ). (Hepatology 2005;42:946–955.)
INVESTIGATION OF INJURIES FROM HAIR DYES, DYED FURS AND COSMETICS
Authors: HAROLD N. COLE
Journal: JAMA (1927)

On the recommendation of the Section on Dermatology and Syphilology, the House of Delegates, in May, 1924, adopted a resolution calling for action to safeguard the public against injuries from dyed furs. hair dyes and cosmetics, and authorized the Board of Trustees to seek legislation if necessary to accomplish that end. The chairman of the section, at the request of the Board of Trustees, appointed a committee to cooperate with the Bureau of Legal Medicine and Legislation in carrying that resolution into effect. It was considered necessary to know as accurately as possible the nature and extent of the injuries that the public may be suffering through the articles named. To arrive at these conclusions the following questionnaire was sent out to those physicians registering as dermatologists in the Section on Dermatology and Syphilology of the American Medical Association at the sessions of from 1920 to 1925,
Salmonellosis Complicating Ulcerative Colitis
Authors: Michael S. Kressner
Journal: JAMA (1982)

IDIOPATHIC ulcerative colitis is a chronic inflammatory disease of the rectum and part or all of the colon characterized by remissions and exacerbations and manifested by abdominal pain, diarrhea, and rectal bleeding. Acute episodes may rapidly progress to a medical emergency with the development of toxic megacolon. An accurate diagnosis is mandatory, yet there are no pathognomonic characteristics, either clinical or histological. Identical features may be seen with specific infections such as Salmonella, Shigella, Campylobacter, Clostridium difficile, Neisseria gonorrhoeae , amebiasis, or in Crohn's colitis. 1 Usually no precipitating factor for acute relapse can be determined. 2 The case to be described illustrates the importance of recognizing a precipitating factor associated with a fulminant relapse of ulcerative colitis.  Report of a Case  A 22-year-old woman with a diagnosis of ulcerative colitis had been followed up for four years; she had been asymptomatic for one year, while receiving sulfasalazine, 3 g/day. Five
Plasma 5-S-cysteinyldopa as an index of melanogenesis
Authors: J.E. NIMMO, D.J. GAWKRODGER, C.St.J. O'DOCHERTY, S.M. GOING, I.W. PERCY-ROBB, J.A.A. HUNTER
Journal: British Journal of Dermatology (1988)

Journal Article Plasma 5‐S‐cysteinyldopa as an index of melanogenesis Get access J.E. NIMMO, J.E. NIMMO Department of Clinical Chemistry, University of Edinburgh, Royal Infirmary, Edinburgh U.K. Search for other works by this author on: Oxford Academic Google Scholar D.J. GAWKRODGER, D.J. GAWKRODGER Department of Dermatology, University of Edinburgh, Royal Infirmary, Edinburgh U.K. Search for other works by this author on: Oxford Academic Google Scholar C.St.J. O'DOCHERTY, C.St.J. O'DOCHERTY Department of Dermatology, University of Edinburgh, Royal Infirmary, Edinburgh U.K. Search for other works by this author on: Oxford Academic Google Scholar S.M. GOING, S.M. GOING Department of Dermatology, University of Edinburgh, Royal Infirmary, Edinburgh U.K. Search for other works by this author on: Oxford Academic Google Scholar I.W. PERCY‐ROBB, I.W. PERCY‐ROBB Department of Clinical Chemistry, University of Edinburgh, Royal Infirmary, Edinburgh U.K. Professor I.W. Percy‐Robb, Department of Pathological Biochemistry, Western Infirmary, Glasgow GII 6NT, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.A.A. HUNTER J.A.A. HUNTER Department of Dermatology, University of Edinburgh, Royal Infirmary, Edinburgh U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 118, Issue 4, 1 April 1988, Pages 487–496, https://doi.org/10.1111/j.1365-2133.1988.tb02457.x Published: 01 April 1988
White Coats Should Not Have Union Labels
Authors: J J Cohen
Journal: New England Journal of Medicine (2000)

Medicine has been subjected to more changes in the past several years than in any other period in the history of our profession. Now comes the decision by the National Labor Relations Board (NLRB) to change its long-standing view about the nature of residents in training. No longer primarily students, says the NLRB, residents are henceforth to be considered primarily employees under the provisions of the National Labor Relations Act.1 Is this change for the better or for the worse?Change, whether for better or worse, is always difficult. Resistance to change seems hard-wired into our nature as human beings. . . .
Mutant dynactin in motor neuron disease
Authors: Imke Puls, Catherine Jonnakuty, Bernadette H. LaMonte, Erika L.F. Holzbaur, Mariko Tokito, Eric Mann, Mary Kay Floeter, Kimberly Bidus, Dennis Drayna, Shin J. Oh, Robert H. Brown, Christy L. Ludlow, Kenneth H. Fischbeck
Journal: Nature Genetics (2003)
Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity
Authors: Kaiqi Sun, Yujin Zhang, Mikhail V. Bogdanov, Hongyu Wu, Anren Song, Jessica Li, William Dowhan, Modupe Idowu, Harinder S. Juneja, Jose G. Molina, Michael R. Blackburn, Rodney E. Kellems, Yang Xia
Journal: Blood (2015)
Colchicine in the treatment of acute febrile neutrophilic dermatosis (Sweet's syndrome)
Authors: S. SUEHISA, H. TAGAMI, F. INOUE, K. MATSUMOTO, K. YOSHIKUNI
Journal: British Journal of Dermatology (1983)

Journal Article Colchicine in the treatment of acute febrile neutrophilic dermatosis (Sweet's syndrome) Get access S. SUEHISA, S. SUEHISA Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan Search for other works by this author on: Oxford Academic Google Scholar H. TAGAMI, H. TAGAMI Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan Search for other works by this author on: Oxford Academic Google Scholar F. INOUE, F. INOUE Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan Search for other works by this author on: Oxford Academic Google Scholar K. MATSUMOTO, K. MATSUMOTO Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan Search for other works by this author on: Oxford Academic Google Scholar K. YOSHIKUNI K. YOSHIKUNI Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 108, Issue 1, 1 January 1983, Pages 99–101, https://doi.org/10.1111/j.1365-2133.1983.tb04584.x Published: 01 January 1983 Article history Accepted: 10 May 1982 Published: 01 January 1983
Ageism in cardiology
Authors: A. Bowling
Journal: BMJ (1999)

This article supports the argument that ageism exists in health care, particularly on the equity of access to cardiological services. Rates of use of potentially life saving and life promoting interventions and investigations decline as the patient gets older. Higher rates of cardiological interventions occur among younger people, despite the high incidence of the condition among older individuals. Any ageism in clinical medicine and policy is simply a reflection of the presence of ageist attitudes in wider society, where the youth receives a higher priority over age. Ageism in medicine needs to be addressed to preserve or recapture this trust within an aging population. A wide ranging approach is necessary if equity in the provision of health care services is to be ensured which includes improvement of clinical guidelines and more specific monitoring of health care. Educational efforts to raise awareness that age stereotyping and ageist attitudes are unethical should be initiated. Research initiatives, which cover large numbers of older people, should be developed and older people should be empowered to influence choices and standards of treatments. Finally, legislation may be required to eradicate ageism in society.
Self-assessments of patients via Tablet PC in routine patient care: comparison with standardised paper questionnaires
Authors: J G Richter, A Becker, T Koch, M Nixdorf, R Willers, R Monser, B Schacher, R Alten, C Specker, M Schneider
Journal: Annals of the Rheumatic Diseases (2008)

<h3>Objective:</h3> We evaluated the feasibility of electronic data capture of self-administered patient questionnaires using a Tablet PC for integration in routine patient management; we also compared these data with results received from corresponding paper–pencil versions. <h3>Methods:</h3> Standardised patient questionnaires (FFbH/HAQ, BASDAI, SF-36) were implemented in our documentation software. 153 outpatients (rheumatoid arthritis, systemic lupus erythematosus, spondyloarthritis) completed sets of questionnaires as paper–pencil and electronic versions using a Tablet PC. The quality and validity of data obtained using a Tablet PC and the capability of disabled patients to handle it were assigned; patients' experiences, preferences and computer/internet use were also assessed. <h3>Results:</h3> Scores obtained by direct data entry on the Tablet PC did not differ from the scores obtained by the paper–pencil questionnaires in the complete group and disease subgroups. No major difficulties using the Tablet PC occurred. 62.1% preferred remote data entry in the future. Seven (4.6%) patients felt uncomfortable with the Tablet PC due to their rheumatic disease. <h3>Conclusions:</h3> Self-administered questionnaires via Tablet PC are a facile and capable option in patients with rheumatic diseases to monitor disease activity, efficacy and safety assessments continuously. Tablet PC applications offers directly available data for clinical decision-making improves quality of care by effective patient monitoring, and contributes to patients' empowerment.
Splinter subgroups of pernicious anemia
Authors: S. Vasirub
Journal: JAMA (1970)

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Trends in Dietary Quality Among Adults in the United States, 1999 Through 2010
Authors: Dong D. Wang, Cindy W. Leung, Yanping Li, Eric L. Ding, Stephanie E. Chiuve, Frank B. Hu, Walter C. Willett
Journal: JAMA Internal Medicine (2014)

Many changes in the economy, policies related to nutrition, and food processing have occurred within the United States since 2000, and the net effect on dietary quality is not clear. These changes may have affected various socioeconomic groups differentially.