tbuckley/cabot-search huggingface dataset:
Surgery of Peptic Ulcer
Authors: M. Prince Brigham
Journal: JAMA (1977)

The contents of this volume, one of the series of<i>Major Problems in Clinical Surgery</i>, covers far more than just the bare surgical aspects of peptic ulcers. It is a volume that delves into all of the medical aspects surrounding peptic ulcers, including history, medical treatment, surgical complications, and theories of ulcer developments. In short, if one were to read this volume thoroughly and retain what he read, he would be considered the absolute and final authority on peptic ulcer in his circle of acquaintance. It is informative, yet interesting and easily read. It is well indexed so that topics are easily found, and bibliographies are at the end of each chapter. Approximately the first two thirds of the book relate to duodenal ulcer and the last third to gastric ulcer. The author does not slight the subject of gastric ulcer in any way, but he uses to advantage and
CLINICAL UTILITY OF IN-111-LEUKOCYTES IN LOCALIZATION OF SITES OF INFECTION
Authors: J. E. Seabold, H. Youn, C. M. Boyd, G. B. Saha
Journal: Clinical Nuclear Medicine (1982)

Bunker, Stephen R. M.D.; Lull, Robert J. M.D.; McAuley, Robert J. M.S.; Brown, Jerry M. M.D.; Hattner, Robert S. M.D.; Telepak, Robert J. M.D.; Hartshorne, Michael F. M.D.; Jackson, John H. M.D.; Huberty, John P. B.S. Author Information
Irresistible environment meets immovable neurons
Authors: Jeffrey Foss
Journal: Behavioral and Brain Sciences (1997)

Quartz &amp; Sejnowski's (Q&amp;S's) main accomplishment is the presentation of increasing complexity in the developing brain. Although this cuts a colorful swath through current theories of learning, it leaves the central question untouched: How does the environment direct neural structure? In answer, Q&amp;S offer us only Hebb's half-century-old suggestion once again.
Use of a pancreatic stent as a guide for endoscopic ultrasound-guided fine-needle aspiration of a solid pancreatic mass lesion in a patient with underlying chronic pancreatitis
Authors: S. Varadarajulu, N. Jhala
Journal: Endoscopy (2008)

Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) has a lower sensitivity for pancreatic mass lesions in the setting of chronic pancreatitis [1] [2]. The EUS appearances associated with chronic pancreatitis limit imaging and therefore the interpretation of the changes seen with pancreatic masses: echo-poor foci in the pancreas make it difficult to decide on which area to puncture, and calcifications lead to acoustic shadowing that can conceal a mass. In addition, cytological interpretation can be challenging because the inflammatory infiltrate can obscure or simulate a pancreatic malignancy. We describe here a patient with underlying chronic pancreatitis in whom pancreatic stenting facilitated the diagnosis of pancreatic cancer at EUS-FNA.
Maxine Lida Leonie Sturdy (née Peto)
Authors: Elizabeth Evans, Robin Sturdy
Journal: BMJ (2004)

Forde Cayley went from medical school straight into service in wartime France and then to Singapore.Captured by the Japanese, he was taken to the infamous River Kwai.The horrors he had witnessed never left him, but he believed in reconciliation, not hatred.As a postwar pioneer of drug treatment for tuberculosis, he took up the respiratory medicine post that he held until retirement.His spare time was divided between BMA activities, his work as a lay reader, and in his prolific vegetable plot.Predeceased by his wife, Eileen, he leaves two sons and three grandsons.
End-systolic volume and long-term survival after coronary artery bypass graft surgery in patients with impaired left ventricular function.
Authors: A W Hamer, M Takayama, K A Abraham, A H Roche, A R Kerr, B F Williams, M C Ramage, H D White
Journal: Circulation (1994)

Left ventricular function is the main predictor of long-term survival in patients with coronary artery disease. In patients with impaired left ventricular function after myocardial infarction, end-systolic volume is a better predictor than the global ejection fraction. We analyzed long-term follow-up of patients with impaired left ventricular function undergoing coronary artery bypass graft surgery to evaluate preoperative predictors of survival.Consecutive patients with ejection fractions < or = 40% (n = 193) who had undergone surgical revascularization were followed to assess the predictive value of preoperative baseline characteristics and catheterization findings for long-term survival. Patients were followed for 133 +/- 30.7 months. At the time of surgery, patient age was 56 +/- 7.9 years and 169 patients (87.6%) had a history of previous myocardial infarction. Thirty-one patients (16%) were female. The ejection fraction was 32 +/- 7%, and the end-systolic volume was 147.4 +/- 52.6 mL. One hundred sixty-four patients (84.9%) had three-vessel disease, and 44 (22.8%) had a left main stenosis with > 50% diameter loss. Follow-up was complete in 99%. Fourteen patients died (7.3%) within the first 30 days after surgery. Twelve-month actuarial survival was 86%, 4-year survival was 80%, and 10-year survival was 40%. Predictors of poor long-term survival on multivariate analysis were end-systolic volume index (chi 2 = 14.02, P = .002), number of previous myocardial infarctions (chi 2 = 6.47, P = .001), preoperative stenosis score (chi 2 = 4.97, P = .02), and age at the time of surgery (chi 2 = 4.45, P = .03).End-systolic volume index is the major predictor of survival after coronary artery bypass graft surgery in patients with impaired left ventricular function. Strategies to prevent ventricular dilatation, such as angiotensin-converting enzyme inhibitors, may improve the long-term outcome in these patients.
Quantitative analysis of styrene monomer in polystyrene and foods including some preliminary studies of the uptake and pharmacodynamics of the monomer in rats.
Authors: J R Withey
Journal: Environmental Health Perspectives (1976)

A variety of food containers, drinking cups and cutlery, fabricated from polystyrene (PS) or polystyrene-related plastic, were analyzed for their styrene monomer content. Samples of yogurt, packaged in PS cups, were similarly analyzed and the leaching of styrene monomer from PS containers by some food simulants was also determined. Blood level studies with rats, dosed with styrene monomer by various routes, illustrated uptake phenomena that were dependent on the dose and route of administration and were also affected by the vehicle used to convey the styrene monomer.
TCT-44 Impact of arterial access on all cause mortality in octogenarians, following Primary Percutaneous Intervention (PPCI) for ST elevation myocardial infarction (STEMI): Insights from Glenfield-Leicester UK ACS registry.
Authors: Herath Ashan Gunarathne, Albert Alahmar, Amerjeet Banning, Anthony Gershlick
Journal: Journal of the American College of Cardiology (2013)
Steroids in Nephrotic Syndrome-Reply
Authors: Walter Heymann
Journal: JAMA (1962)

To the Editor:—  In answer to Dr. Rugstad's comments, I do agree with him that the rate of recovery from the nephrotic syndrome in children can, to a certain extent, be determined by the duration of the disease process. In fact, the data of our publication in question seem to support this contention for the first time. To shorten the duration of this variable disease has thus been our aim. How else could this be achieved today than by earlier institution of intensive long-term steroid administration? I do not assume that 29 of 34 nephrotic children given a placebo within 3 months after onset of their disease would be free of any detectable renal pathology over several years of observation. All available data up to 1954, when long-term, intensive regimen of steroid treatment of the nephrotic syndrome was first started in the United States, speak against such a possibility.
The Spinal Cord; Basic Aspects and Surgical Considerations
Authors: Russell Meyers
Journal: JAMA (1961)

This is a new and timely book, which addresses itself to the twin tasks of synopsizing and elucidating the core information now in the storehouse of scientific knowledge bearing upon the surgically amenable diseases of the adult, human spinal cord. The level of its technologic orientation, as well as the selected contents of its 46 chapters, indicate that the work is primarily intended for the neurosurgeon and the resident training in the neurosurgical discipline. However, it contains much that is of value to the clinical neurologist, internist, radiologist, orthopedist, urologist, general surgeon, general practitioner, and medical student. No doubt it will also prove conspicuously helpful to attorneys, judges, industrial commissioners, and others engaged with the multifarious and ever-increasing problems of forensic medicine. The sections on spinal trauma, neoplasms, treatment of intractable pain, and regeneration were written by Dr. George Austin, and the section on intervertebral disc disease was written jointly
Who Wants a Healthful Breakfast?
Authors: Robert S. Sandler
Journal: New England Journal of Medicine (1994)

To the Editor: Despite recommendations to the contrary, many Americans continue to select a diet that is high in cholesterol and saturated fat. The fixed choices presented to airline travelers may provide a crude but informative measure of dietary preferences. On one early-morning flight, the choice consisted of a “healthy” breakfast (Kellogg's Special K, skim milk, a whole-grain muffin, and a banana) or a standard breakfast (a cheese omelet and sausage). According to the managing director of the food and beverage services for American Airlines, 60 percent of first-class passengers and 70 percent of coach passengers select an omelet over . . .
Dynamic blood coagulation and viscosity and degradation of artificial thrombi in patients with hypertension
Authors: L. Dintenfass, G. E. Bauer
Journal: Cardiovascular Research (1970)

Journal Article Dynamic blood coagulation and viscosity and degradation of artificial thrombi in patients with hypertension Get access Leopold Dintenfass, Leopold Dintenfass From the Department of Medicine, University of Sydney, and the Haemorheology Unit, Sydney Hospital; and from the Cardiovascular Clinic, Sydney Hospital, Sydney, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Gaston E. Bauer Gaston E. Bauer From the Department of Medicine, University of Sydney, and the Haemorheology Unit, Sydney Hospital; and from the Cardiovascular Clinic, Sydney Hospital, Sydney, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 4, Issue 1, January 1970, Pages 50–60, https://doi.org/10.1093/cvr/4.1.50 Published: 01 January 1970 Article history Accepted: 31 July 1969 Published: 01 January 1970
The Voice: A Memoir
Authors: Tony Miksanek
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Postgraduate Obstetrical and Gynaecological Pathology
Authors: Robert E. Scully
Journal: JAMA (1973)

This volume, with 27 chapters by 21 authors, is the expanded version of a course in obstetrical and gynecological pathology given at the University of Manchester and aimed primarily at postgraduate students in pathology and gynecology. The editors did not intend to produce a text for the undergraduate student or a comprehensive reference volume for the specialist in gynecologic pathology. The subjects covered differ considerably from those appearing in conventional textbooks. There are the usual chapters on the development and pathology of the female genital tract and placenta, but the sections on cytology deal only with problems encountered in preparing, interpreting, and reporting smears, and with endocrine disorders. Other chapters discuss diseases of the blood and kidney in pregnancy, the amniotic fluid, the pathology of maternal and perinatal death, cerebral birth injury, and hypoxia in the fetus and newborn. Several chapters are concerned more with normal and abnormal biochemical and
Ravages of Copper in Early Wilson's Disease
Authors: Samuel Vaisrub
Journal: JAMA (1977)

Transient intravascular hemolysis as an isolated presentation of Wilson's disease was first reported in 1934.<sup>1</sup>Sporadic reports of this phenomenon, which may precede other symptoms of hepatolenticular degeneration by several years, have appeared since. In this issue, Robitaille and associates (p 2402) describe three additional cases of Wilson's disease with transient hemolytic anemia as a presenting manifestation, which was associated with an unexpected and unexplained elevation of A<sub>2</sub>hemoglobin. The transient hemolysis was not an isolated manifestation. One patient had an enlarged liver; another had ascites and cholestatic jaundice. The involvement of the liver did not, however, substantially affect prognosis. All three patients responded to penicillamine therapy. A happy ending does not, unfortunately, follow every case of intravascular hemolysis associated with hepatic involvement. Roche-Sicot and Benhamou<sup>2</sup>report three young patients with Wilson's disease in whom this association resulted in a fatal outcome. Death was due not to
Letter by Chin et al Regarding Article, “Efficacy and Safety of Dabigatran Compared With Warfarin in Relation to Baseline Renal Function in Patients With Atrial Fibrillation: A RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) Trial Analysis”
Authors: Paul K. L. Chin, Daniel F. B. Wright, Christopher M. Florkowski
Journal: Circulation (2014)
Still waiting and searching for answers
Authors: Emilio Maestri, Susanna Maltoni, Vittorio Basevi, Annamaria Marata, Nicola Magrini
Journal: BMJ (2008)

Clinicians working in the subject area of menopausal problems are still waiting for answers from trials designed to give results on relevant topics in the treatment of climacteric complaints.

Two important trials were planned (and registered) to define the efficacy and safety of tibolone versus placebo in preventing osteoporotic fractures (LIFT)1 and managing menopausal symptoms in women after treatment for breast malignancy (LIBERATE).2 The start of the two studies received great attention from the media; repeated attention was sparked by every favourable report of the study data and …
Gefilte Fish and Diphyllobothriasis
Authors: Richard D. Plotz
Journal: JAMA (1982)

<h3>To the Editor.—</h3> I read the letter from Dr Loeb on gefilte fish and diphyllobothriasis (1982;247:1566). It was my late uncle, Dr Milton Plotz, who first described this association in the pages ofThe Journaljust 50 years ago (1932;98:312). While a resident in internal medicine at Brooklyn Jewish Hospital, my uncle had as patients two middleaged Jewish women with unquestionable diphyllobothriasis, who vehemently (and somewhat disgustedly) denied ever eating raw fish. While puzzling over the occurrence of such an obscure infestation in such a familiar population, he happened to observe his mother preparing gefilte fish in their apartment. He idly asked her, "How do you know when it tastes right?" She replied, "I take a little pinch, like this," and popped some of the mixture into her mouth. A light flashed in my uncle's mind and, of course, it turned out that his patients had been tasting their gefilte
The Edema of Arterial Reconstruction
Authors: E. A. HUSNI
Journal: Circulation (1967)

Edema of the foot and leg incident to successful arterial surgery was evaluated in 137 arterial reconstructions on the lower extremity. Both the postoperative hyperemia and the edema appeared to be directly related to the degree of pre-existent ischemia. When employed, heparin or dextran or both were effective in preventing postoperative phlebitis but did not alter the postoperative hyperemia and edema. Furthermore, phlebograms and pressure studies obtained in edematous extremities disclosed normal venous morphology and hemodynamics. The underlying mechanism for this edema is believed to be the sudden re-establishment of high pressure in an atrophic arterial tree previously exposed to a reduced intravascular pressure of long duration. This effects overstretching of the arterial bed and a remarkable increase in capillary filtration. A significant secondary factor is the compromised venous return incident to muscular atrophy and limited joint movements that are prevalent in ischemic limbs.
Buruli ulcer in Ghana.
Authors: A C Bayley
Journal: BMJ (1971)

Presentation and CD4<sup>+</sup> T cell responses to Ag in the context of MHC class II molecules require processing of native proteins into short peptide fragments. Within this pathway, IFN-γ-inducible lysosomal thiol reductase (GILT) functions to catalyze thiol bond reduction, thus unfolding native protein Ag and facilitating further processing via cellular proteases. In contrast with professional APCs such as B cells, class II-positive human melanomas expressed relatively little to no GILT protein or mRNA. Tumor cell GILT expression was partially restored with IFN-γ treatment but unlike other genes required for class II Ag presentation, GILT was not regulated by CIITA. Rather, studies revealed STAT1 plays a direct role in IFN-γ-inducible GILT expression. These results define a molecular mechanism for the uncoupled regulation of MHC class II genes and the processing enzyme GILT in human melanomas.
Specialty Board Review: Obstetrics and Gynecology
Authors: Susie Reitz
Journal: JAMA (1979)

From a medical student's point of view, information in this second edition of<i>Specialty Board Review: Obstetrics and Gynecology</i>is educational, interesting, and rationally presented. For physicians reviewing basic obstetrics and gynecology for specialty boards, it may be helpful. The book's design with answers and explanations at the end of each chapter as well as numbered references enable one to find additional information in areas of weakness quickly. One consideration is the $14 price tag for this paper-bound volume. In this case it is probably a good investment for those interested in economy of time and memory-tickling questions, but it is for onetime use only. The questions cover a wide range of subjects and are similar to board-type questions. The publishers, however, have neglected to include a "let's pretend" sample answer sheet for test practice, which some board-review packets and test booklets contain. Nothing distinguishes this book from other board-review
A Central Nervous System-Restricted Isoform of the Interleukin-1 Receptor Accessory Protein Modulates Neuronal Responses to Interleukin-1
Authors: Dirk E. Smith, Brian P. Lipsky, Chris Russell, Randal R. Ketchem, Jacqueline Kirchner, Kelly Hensley, Yangyang Huang, Wilma J. Friedman, Vincent Boissonneault, Marie-Michèle Plante, Serge Rivest, John E. Sims
Journal: Immunity (2009)
Tracking autoimmune T cells in diabetes
Authors: David V. Serreze, Edward H. Leiter
Journal: Journal of Clinical Investigation (2003)

Insulin-dependent diabetes mellitus is usually caused by the autoimmune destruction of pancreatic β cells by T cells. Methodologies to track the development, migration, and functional activation of one class of such T cells (CD4 T cells) have been limited. However, it now appears that this limitation has been overcome .
Gentamicin Dosages for Renal Insufficiency
Authors: MARTIN C. MCHENRY
Journal: Annals of Internal Medicine (1971)

The percent hourly loss and serum half-life (T½) of gentamicin were determined after an intramuscular dose of from 0.8 to 1.5 mg/kg body weight in each of 18 patients with various degrees of impaired renal function and in 6 patients with normal renal function. There was a linear relationship between the loss of gentamicin and the endogenous creatinine clearance (CCr). The percent hourly loss could be estimated by dividing the value of the CCr (ml/min/1.73 m2 body surface area) by four. There was a curvilinear relationship between the serum creatinine concentration and the T½ of gentamicin. The nature of the curve was such that for clinical purposes the T½ of gentamicin could be estimated by multiplying the value of the serum creatinine (mg/100 ml) by four. These data provide a possible basis for individualized adjustment of dosage of gentamicin for patients with impaired renal function.
A practical guide to monitoring for adverse drug reactions during antihypertensive drug therapy
Authors: Sarah E Mcdowell, Sarah K Thomas, Jamie J Coleman, Jeffrey K Aronson, Robin E Ferner
Journal: Journal of the Royal Society of Medicine (2013)

Summary Monitoring of patients taking antihypertensive treatment can identify potential adverse drug reactions (ADRs). However, published guidelines give divergent or incomplete recommendations on monitoring for ADRs. Using a predetermined strategy, we undertook a systematic review to identify hypertension guidelines published from January 2001 to October 2011 with recommendations for monitoring for ADRs. We screened 88 abstracts and 187 web-based guidelines, and identified 19 published guidelines on monitoring the biochemical effects of antihypertensive drug therapy. We then produced a set of practical clinical guidelines, synthesized from those recommendations. Our recommendations are designed to provide efficient monitoring. They reduce the number of tests to a minimum consistent with safe practice and align monitoring schedules, so that creatinine, potassium and sodium concentrations are measured at the same times in all cases. The instructions for biochemical monitoring in current guidelines differ greatly, both in the extent of advice and in the detail provided. The current lack of consistent and workable instructions poses serious difficulties for practitioners. The recommendations distilled from this systematic review should help practitioners when they monitor therapy with antihypertensive drugs.
Monoclonal antibodies: key to a revolution in clinical medicine
Authors: Catherine Macek
Journal: JAMA (1982)

Monoclonal antibodies, believed by many scientists to be the realization of Paul Ehrlich's decades-old "magic bullet" theory, are fast becoming the ammunition against a wide variety of diseases. The secretory products of cells called "hybridomas" (hybrid-myelomas), monoclonal antibodies are the final outcome of a laboratory manipulation whereby antibody-producing B lymphocytes (B cells) are fused with myeloma cells. The resulting hybrid cell line expresses the desirable characteristics of both parents: It produces antibodies of the same single specificity as the B cell and it is "immortalized" because of its cancerous parentage. The fusion technique would be unnecessary if nonmalignant B cells could be cloned and maintained in cell culture, but this has not been possible. Myelomas, on the other hand, synthesize antibody indefinitely, as evidenced by the quantity of Bence Jones protein in the urine of myeloma patients and in the supernates of myeloma cell cultures. The hybridoma technique was first