tbuckley/cabot-search huggingface dataset:
Left ventricular diastolic capacity in man.
Authors: A P Flessas, T J Ryan
Journal: Circulation (1982)

Plasma volume expansion with 500 ml of low-molecular-weight dextran was used in 27 patients (nine normal subjects, 13 patients with ischemic heart disease, four with aortic stenosis and one with cardiomyopathy) to increase left ventricular end-diastolic pressure (LVEDP) from a control value of 12.4 +/- 7.0 mm Hg (mean +/- SD) to 23.3 +/- 7.0 mm Hg and end-diastolic volume (EDV) from 84.0 +/- 23.8 ml/m2 to 97.6 +/- 22.9 ml/m2. EDV-LVEDP curves constructed for 12 patients from multiple angiograms at progressively increasing LVEDPs during plasma volume expansion showed an initial part where EDV increased in parallel with LVEDP and a final steep or perpendicular part where EDV increased minimally or not at all as LVEDP exceeded 20 mm Hg. Exponential equations were used to fit diastolic volume-pressure data obtained with catheter-tip manometers in seven patients: the exponential constant, k, was 0.012-0.044 ml-1 and was inversely related to EDV (Spearman's rank correlation coefficient = -1). For comparable EDV, there were no differences in k values between normal subjects and patients with a variety of heart diseases.
A case of porphyria cutanea tarda with experimental light urticaria
Authors: M. ICHIHASHI, K. HASEI, T. HORIKAWA
Journal: British Journal of Dermatology (1985)

Photobiological tests were carried out on a 32-year-old man who suffered from porphyria cutanea tarda (PCT). The patient developed an immediate type of skin reaction with erythema and whealing following monochromatic irradiation at 400 nm, but did not have any abnormal immediate skin reaction after exposure to natural sunlight. Pre- or simultaneous irradiation with visible light, wavelength greater than 650 nm, suppressed the development of urticaria induced by 400 nm monochromatic radiation. On the basis of these findings and our previous observation of an inhibitory spectrum in two cases of solar urticaria, we suggest that there is also an inhibitory spectrum in PCT. This could explain the extremely low incidence of immediate erythematous or urticarial reactions in sun-exposed skin in these patients.
M-mode and two-dimensional echocardiographic features in cardiac amyloidosis.
Authors: A G Siqueira-Filho, C L Cunha, A J Tajik, J B Seward, T T Schattenberg, E R Giuliani
Journal: Circulation (1981)

Twenty-eight patients with cardiac amyloidosis were studied by echocardiography -- 26 by M-mode and 13 by two-dimensional (2D) studies. All had heart failure and biopsy-proved amyloidosis, M-mode features included (1) normal left ventricular (LV) dimension in all; (2) thickened ventricular septum (88%), LV posterior wall (77%), and right ventricular (RV) anterior wall (79%); (3) decreased thickening of ventricular septum (96%) and of LV posterior wall (65%) and reduced LV global function (62%); (4) left atrial enlargement (50%); and (5) pericardial effusion (58%). Two-dimensional echocardiography provided additional features: (1) thickened papillary muscles (five of 13); (2) thickened valves (four of 13); (3) better appreciation of thickened RV wall; and (4) a characteristic "granular sparkling" appearance of thickened cardiac walls -- presumably secondary to the amyloid deposit -- which was noted in 12 of 13 patients. Thus, M-mode echocardiography is helpful in the recognition of cardiac amyloidosis. However, the better appreciation with 2D echocardiography of thickened cardiac walls with a "granular sparkling" appearance in patients with unexplained cardiac failure is virtually diagnostic of cardiac amyloidosis.
Meningitis B vaccine to be introduced in UK after U turn on its cost effectiveness
Authors: J. Wise
Journal: BMJ (2014)

The meningococcal B vaccine Bexsero is to be brought into the childhood vaccination programme in the United Kingdom if it can be purchased at a low price, the Department of Health for England has said.

The decision comes after a U turn by the Joint Committee on Vaccination and Immunisation. Last July it said that the vaccine would not be cost effective in an infant vaccination programme at any price.1 However, after widespread protest, the committee carried out a consultation with stakeholders and then repeated the cost effectiveness analysis with additional information.

As a result of this new analysis the committee has now said that it would recommend Bexsero if it could be bought at a cost effective price.2 It said that cost effectiveness would be improved through the use of an abbreviated schedule at ages 2, 4, and 12 months, which would be sufficiently immunogenic.

The vaccine’s manufacturer, Novartis, …
24- and 6-month dual antiplatelet therapy after coronary stenting did not differ for clinical outcomes
Authors: Brigitta C. Brott, William B. Hillegass
Journal: Annals of Internal Medicine (2012)

Source Citation Valgimigli M, Campo G, Monti M, et al; Prolonging Dual Antiplatelet Treatment After Grading Stent-Induced Intimal Hyperplasia Study (PRODIGY) Investigators. Short- versus long-term duration of dual antiplatelet therapy after coronary stenting: a randomized multicenter trial. Circulation. 2012;125:2015-26. 22438530
Maurice Gerald Nelson
Authors: J M Bridges, E E Mayne
Journal: BMJ (2006)

​FormerFormer consultant clinical pathologist and professor of haematology Belfast (b 1914; q Queen's University, Belfast, 1937; MD, FRCPI, FRCP), d 4 November 2005.



Figure 1



Gerald Nelson was appointed consultant clinical pathologist at the Royal Victoria Hospital, Belfast, in 1947, but within a few years haematology became his specialty. A pioneer in the automation of laboratory procedures, he was a member of the Department of Health Laboratory Advisory Group and chairman of the haematology subgroup. Clinically he developed a haematology inpatient unit and one of the first outpatient and day treatment facilities. He was responsible for the establishment of the Northern Ireland Haemophilia Centre. In 1971 Queen's University appointed him to a personal chair. Predeceased by a son, he leaves a wife, Hazel; two children; and grandchildren.
P2-295: Phase II trial a 2-h infusion of Gemcitabine-carboplatin combination as first-line therapy for stage IIIB or IV non-small cell lung cancer
Authors: Bárbara M. Parente, Fernando Barata, Ana Fernandes, Encarnação Teixeira, Teresa Almodovar, Ana Barroso, Sara Conde, Ana Figueiredo, Duro Costa
Journal: Journal of Thoracic Oncology (2007)
15-deoxy-Δ<sup>12,14</sup>-prostaglandin J<sub>2</sub>reduces recruitment of bone marrow-derived monocyte/macrophages in chronic liver injury in mice
Authors: Zhen Han, Tieping Zhu, Xihong Liu, Changyong Li, Shi Yue, Xin Liu, Le Yang, Lin Yang, Liying Li
Journal: Hepatology (2012)

15-Deoxy-Δ 12,14 -Prostaglandin J 2 (15d-PGJ 2 ), a natural peroxisome proliferator-activated receptor gamma (PPAR-γ) ligand, has been implicated as a new antiinflammatory compound with possible clinical applications. Based on this concept, this study was designed to evaluate the effects of 15d-PGJ 2 on bone marrow–derived monocyte/macrophage (BMM) migration, phagocytosis, and cytokine expression after liver injury using mouse models induced by cholestasis or carbon tetrachloride. Mice were lethally irradiated and received bone marrow transplants from enhanced green fluorescent protein transgenic mice. Our results showed that recruitment of BMM was significantly increased during chronic liver injury, and that 15d-PGJ 2 administration reduced BMM, but not neutrophil, dendritic, or T cell migration toward the damaged liver, involving reactive oxygen species generation and independently of PPAR-γ. Moreover, 15d-PGJ 2 inhibited the phagocytic activity of BMM and down-regulated inflammatory cytokine expression in vivo and in vitro . Accordingly, hepatic inflammation and fibrosis were strikingly ameliorated after 15d-PGJ 2 administration. Conclusion : Our findings strongly suggest the antiinflammation and antifibrogenic potential of 15d-PGJ 2 in chronic liver diseases. (HEPATOLOGY 2012;56:350–360)
Fish tank granuloma.
Authors: S F Gray, R S Smith, N J Reynolds, E W Williams
Journal: BMJ (1990)

Mycobacterium marinum is an opportunist pathogen commonly found in aquatic environments.Infected fish may develop a disseminated granulomatous disease-fish tuberculosis-that leads to wasting and ultimately to death.In humans this organism causes local infection after contamination of open wounds or abrasions.M marinum skin infection acquired from tropical fish tanks was first described in 1962 by Swift and Cohen,' and has since been reported by many workers world wide.2M marinum is the causative organism in swimming pool granuloma, which is well known in the United Kingdom3; infections of humans with M marinum after fishing, boating, and other exposure to salt and brackish water has also been described.47We report on four patients who were diagnosed as having M marinum infection causing tropical fish tank granuloma over eight months in 1988.There had been no other cases locally in the previous five years.Epidemiologically there was no link among the cases. Case reportsCase I-A 36 year old shop fitter cut his thumb while cleaning his fish tank.The wound failed to heal despite
TCT-64 Bypassing The Emergency Department Is Associated With Faster Reperfusion In Patients With Pre-Hospital ST-Segment Elevation: Findings From The Reperfusion Of Acute Myocardial Infarction In Carolina Emergency Departments (RACE) Project
Authors: Akshay Bagai, Hussein Al-Khalidi, Daniel Munoz, Lisa Monk, Mayme Roettig, Christopher Granger, James Jollis
Journal: Journal of the American College of Cardiology (2012)
Methyldopa-lnduced Granulomatous Hepatitis
Authors: Alex C. Miller
Journal: JAMA (1976)

METHYLDOPA has been an effective and usually well-tolerated antihypertensive agent in clinical practice. However, hypersensitivity reactions to the drug are well documented and have been manifested by fever, constitutional complaints, and liver disease.<sup>1-7</sup>We report a case of granulomatous hepatitis due to methyldopa therapy. To our knowledge, similar histopathologic changes have not been reported previously. <h3>Report of a Case</h3> A 49-year-old woman with previously well-documented essential hypertension was admitted to Carraway Methodist Medical Center in June 1973 with a five-day history of generalized repetitive chills, temperature of 39 to 40 C, myalgias, mild watery diarrhea, and severe nausea and vomiting. Her past medical history was unremarkable except for hypertension, which had been managed with hydrochlorothiazide for two years. Two days prior to the onset of her clinical illness, methyldopa, 250 mg twice daily, was added to her antihypertensive regimen. On physical examination, she was alert, acutely ill, and dehydrated
The Renal Functional Defect of Postobstructive Nephropathy
Authors: John R. Jaenike
Journal: Journal of Clinical Investigation (1972)

This study was designed to examine the pathogenesis of the excretory defect produced by bilateral ureteral obstruction in the rat. After release of obstruction of 24 hr duration glomerular filtration rate was reduced to 20% of normal. Free flow proximal tubular pressure was normal, excluding residual obstruction as a cause of depressed filtration, and indicating that an intrarenal hemodynamic abnormality was primarily responsible for the excretory defect. Total renal blood flow and cortical distribution of flow were normal. Clearance and micropuncture studies indicated the presence of marked heterogeneity of nephron function with residual excretory function residing primarily in vasodilated nephrons in which decreased postglomerular arteriolar resistance effected a reduction in glomerular filtration pressure. Heterogeneity of nephron function was evidenced by a wide scatter of values for single nephron filtration rate and from direct intratubular injection of dye which revealed that at least 28% of surface nephrons were either nonfiltering or had filtration rates too low to measure. The observed decrease in Hippuran extraction and increased ratio of Hippuran to inulin clearance ratio is characteristic of the vasodilated kidney. Further evidence of the vasodilated nature of residual functioning nephrons was demonstrated by the failure of intrarenal papaverine infusion to increase filtration rate in this lesion. The hemodynamic defect produced by bilateral obstruction is contrasted with that seen after release of unilateral ureteral ligation in which depression of filtration rate appears to result primarily from preglomerular vasoconstriction. This difference raises the possibility that a vasodilating substance accumulates during total suppression of renal excretory function. Diuresis and natriuresis were constant features of the postobstructive lesion. The present data support previously published studies which localize the defect in sodium transport to the distal nephron and indicate that this defect is a consequence of increased intraluminal pressure and tubular dilatation induced by bilateral ureteral ligation.
Minisatellite diversity supports a recent African origin for modern humans
Authors: John A.L. Armour, Tiiu Anttinen, Celia A. May, Emilce E. Vega, Antti Sajantila, Judith R. Kidd, Kenneth K. Kidd, Jaume Bertranpetit, Svante Pääbo, Alec J. Jeffreys
Journal: Nature Genetics (1996)
IMPORTANCE OF ATTENTION TO UPPER RESPIRATORY TRACT IN ACUTE OTITIS MEDIA
Authors: J. W. Jervey
Journal: JAMA (1918)

<h3>To the Editor:</h3> —In Society Proceedings,The Journal, July 27, 1918, p. 307, in a report of the Lenox meeting of the American Pediatric Society, there is an abstract of a paper by Dr. Thomas S. Southworth of New York entitled "Are the Present Frequency of Acute Otitis Media and the Subsequent Mastoid Operation in Some Measure a Reproach to Pediatrics?" Accompanying it is an abstract of a discussion by eight well known pediatricians. The paper, with the discussion, is apparently intended to cover, in a general way, the prevention and treatment of acute middle ear inflammation and the prevention of mastoid involvement. I am pained beyond expression to observe that, so far as these abstracts are concerned, there is not a single instance of the mention of the most important consideration in the care and prevention of these cases, which is careful attention to the upper respiratory tract, with
???Short Pants??? Finding on Bone Images in Paget??s Disease with Paralysis
Authors: JOHN MATHEWS, MOZAFAREDDIN K. KARIMEDDINI, RICHARD P. SPENCER
Journal: Clinical Nuclear Medicine (1986)

A Tc-99m HDP bone image in a man revealed extraosseous accumulation in a “short pants” distribution. This may have been related to his spastic paralysis, skin ulcers, and Paget's disease.
Demonstration of the high-affinity IgE receptor on human Langerhans cells in normal and diseased skin
Authors: J. GRABBE, N. HAAS, K. HAMANN, G. KOLDE, J. HAKIMI, B.M. CZARNETZKI
Journal: British Journal of Dermatology (1993)

Summary Epidermal dendritic cells of normal adult foreskin, and of lesional skin from patients with atopic eczema, stasis eczema and urticaria pigmentosa are shown to be highly reactive with two different monoclonal antibodies (29C6 and 6F7) specific for extracellular domains of the α-chain of the high-affinity IgE receptor. By their distribution pattern, the reactive cells are Langerhans cells. This is confirmed by immunoelectron microscopic demonstration of Birbeck granules in the labelled epidermal cells. Very weak staining is observed on the same cells with an antibody (TÜl) against the low-affinity IgE receptor. Pre-incubation of the sections with IgE partially blocks binding of 6F7 antibody. Langerhans cells, together with dermal mast cells, can therefore bind IgE with high efficiency, and may in this way participate in IgE-mediated cutaneous diseases.
What am I doing here?
Authors: David Crosby, John Henry Jones
Journal: BMJ (2004)

In our separate ways, we and Professor Harold Scarborough started at the Welsh National School of Medicine in the early 1950s—he as professor of medicine, and we as first year clinical medical students. As the coauthor of a standard textbook of physiology (Bell, Davidson, and Scarborough), his name was already well known.

From the outset, he introduced a clear break from the didactic nature of teaching to which we were …
Quantification of local changes in myocardial motion by diffeomorphic registration via currents: Application to paced hypertrophic obstructive cardiomyopathy in 2D echocardiographic sequences
Authors: Nicolas Duchateau, Geneviève Giraldeau, Luigi Gabrielli, Juan Fernández-Armenta, Diego Penela, Reinder Evertz, Lluis Mont, Josep Brugada, Antonio Berruezo, Marta Sitges, Bart H. Bijnens
Journal: Medical Image Analysis (2014)
Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA): long-term follow-up of the Northwestern University experience
Authors: Punit Chadha, Alfred W. Rademaker, Prateek Mendiratta, Benjamin Kim, Darren M. Evanchuk, David Hakimian, LoAnn C. Peterson, Martin S. Tallman
Journal: Blood (2005)
Effects of Pulmonary Endarterectomy on Echocardiographic Parameters and 6-MWT in Patients with Pulmonary Endarterectomy
Authors: Tarık Kıvrak, Murat Sünbül, Alper Kepez, Erdal Durmuş, Bedrettin Yıldızeli, Bülent Mutlu
Journal: Journal of the American College of Cardiology (2013)
Closure of abdominal wounds by adhesive strips: a clinical trial.
Authors: D J Webster, P W Davis
Journal: BMJ (1975)

In a randomized trial of wound closure in 512 abdominal wounds, wounds were closed with either reinforced Steristrip skin closures or interrupted silk sutures. Comparisons were made of wound pain and discomfort, wound infection, discharge, redness, width, and skin reaction. The causes of peeling of the tapes were assessed. The results showed that tapes were significantly more comfortable and that patients preferred them to sutures (P less than 0.01), but wide scars occurred more often. There was no difference in rates of wound infection and no case of allergy to the tapes was seen. Closure of abdominal wounds by these tapes is a satisfactory procedure that could be used more extensively.
Structural and functional studies of ligandin, a major renal organic anion-binding protein.
Authors: R Kirsch, G Fleischner, K Kamisaka, I M Arias
Journal: Journal of Clinical Investigation (1975)

Sephadex gel filtration of the 1000,000 g supernate of homogenates of rat kidney revealed binding of various organic anions (penicillin, Bromsulphalein [BSP], bilirubin, phenolsulfonphthalein [PSP], phlorizin, glutathione [GSH], p-amino hippurate (PAH), probenecid, conjugated bilirubin, and BSP-GSH) to a nonalbumin-containing protein fraction (Y), which precipated on addition of monospecific anti-rat liver ligandin (Y protein)-IgG, but not control IgG. Quantitatively similar organic anion binding was observed in vivo after injection of BSP, BSP-GSH, phlorizin, probenecid, conjugated bilirubin, PAH, or penicillin. The binding protein was purified to apparent homogeneity and is a basic protein (pI 8.9) of 44,000 daltons with two apparently identical subunits of 22,000 daltons. Monospecific antibody was produced against the renal protein. The results of binding studies in vivo and in vitro and phsicochemical, immunologic, structural, and binding site investigations indicate that the renal protein is identical to hepatic ligandin. Immunofluorescent studies utilizing anti-ligandin IgG previously localized ligandin in the kidney to all proximal tubular cells. By quantitative radial immunodiffusion, the concentration of renal ligandin was 31.2 plus or minus 2.2 mug/mg supernatant protein and was increased 160% above basal values by pretreatment of rats with tetrachloro-dibenzo-p-dioxin. Pretreatment with phenobarbital, DDT, or pregnene-16alpha-carbonitrile did not increase renal ligandin concentration but doubled hepatic ligandin concentration. Circular dichroism studies of renal ligandin revealed percent helical structure similar to hepatic ligandin and primary association contrasts were derived for BSP (10-6 M-1) and PAH, probenecid, and penicillin (10-3 M-1). Administration of BSP or probenecid simultaneously with [C14] penicillin resulted in increased plasma retention and reduced kidney and urinary bladder content of [14C] penicillin and a correlation coefficient of -0.8 between total kidney/plasma radioactivity and percent of protein-bound radioactivity bound to ligandin in the kidney. These studies indicate that renal and hepatic ligandin are identical. Their response to drugs and chemicals varies. Competitive binding between several organic anions for ligandin correlated with their renal uptake from plasma, which suggests that ligandin may function in the proximal tubular cell as a component of the renal organic anion transport system.
Tumor Necrosis Factor Receptors 1 and 2 Differentially Regulate Survival, Cardiac Dysfunction, and Remodeling in Transgenic Mice With Tumor Necrosis Factor-α–Induced Cardiomyopathy
Authors: Yoshihiro Higuchi, Charles F. McTiernan, Carole B. Frye, Brian S. McGowan, Tung O. Chan, Arthur M. Feldman
Journal: Circulation (2004)

Background— Tumor necrosis factor (TNF)-α plays a pathophysiological role in heart failure. Although both TNF receptor 1 (TNFR1) and 2 (TNFR2) are present in the heart, comparatively little is known about the role of TNFR2. Methods and Results— We bred TNFR1-knockout (KO) or TNFR2KO mice to transgenic (TG) mice with cardiac-specific overexpression of TNF-α and analyzed resultant progeny. Six groups of male and female mice were studied: wild type (WT) with wild receptors (WT/W), TG with wild receptors (TG/W), TG with heterozygous receptor KO (TG/R1 +/− or TG/R2 +/− ), and TG with homozygous receptor KO (TG/R1 −/− or TG/R2 −/− ). Both male and female TG mice displayed cardiac hypertrophy, dilation, and reduced cardiac function. Male TG mice were more severely affected than genotypically matched females and died of heart failure at a younger age. Survival, cardiac function, and remodeling of TG/R1 +/− and TG/R1 −/− mice were improved relative to TG/W mice in both males and females. However, the survival of female TG/R2 +/− and TG/R2 −/− mice was worse than that of TG/W mice, with increased left ventricular dimension and left ventricular weight/body weight ratios. The cardiac TNF-α protein level was upregulated in TG/R1 −/− and TG/R2 −/− compared with TG/W mice, whereas the level of TNF receptors was not downregulated in TG/W relative to WT/W mice. Conclusions— Ablation of the TNFR2 gene exacerbates heart failure and reduces survival, whereas ablation of TNFR1 blunts heart failure and improves survival. Signaling via TNFR2 may play a cardioprotective role in the pathogenesis of cytokine-mediated heart failure.
Endoscopic ultrasound-guided cholangiography and intraluminal needle puncture through a tight subhilar bile duct stricture for biliary stenting following failed ERCP
Authors: V. Dhir, S. Vivekanandarajah, S. Bhandari, M. Bapat, A. Maydeo
Journal: Endoscopy (2013)

Endoscopic therapy by endoscopic retrograde cholangiopancreatography (ERCP), stricture dilation, and sequential multiple stent placement is the standard treatment option for benign biliary strictures, and has favorable results [1]. Occasionally, tight biliary stricture can pose a technical challenge by not allowing the guide wire to pass. Recently, endoscopic ultrasound (EUS)-guided biliary access has been shown to be safe and successful in cases of failed ERCP due to inability to cannulate [2]. It is not known whether the EUS-guided rendezvous procedure also facilitates guide wire passage across difficult strictures. We report a case of post-cholecystectomy subhilar stricture in which ERCP-guided passage of the guide wire across the stricture was unsuccessful. Hence, EUS-guided cholangiography was carried out followed by intraluminal needle puncture of the stricture with a 18-gauge needle device to pass the guide wire, with completion of the ERCP and stenting.