The Response of Metabolic Alkalosis in Severe Hypertension to Antihypertensive Drugs
Authors: MARK L. ARMSTRONG
Journal: Annals of Internal Medicine (1963)

Case Studies1 February 1963The Response of Metabolic Alkalosis in Severe Hypertension to Antihypertensive DrugsMARK L. ARMSTRONG, M.D., ANNETTE E. FITZ, M.D., LOUIS SCHWARTZ, M.D.MARK L. ARMSTRONG, M.D., ANNETTE E. FITZ, M.D., LOUIS SCHWARTZ, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-2-336 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA case of metabolic alkalosis that occurred in association with idiopathic malignant hypertension and disappeared after antihypertensive drug therapy is reported.Hypertensive disease per se has no connotation of electrolyte or acid-base disturbance. Even in the malignant phase of hypertension, electrolyte balance is usually normal (1), or only mildly changed (2), before renal insufficiency or congestive heart failure occurs. However, aldosterone excretion tends to increase throughout all levels of hypertension (3-5), and may increase remarkably in malignant hypertension (2). Against such a background, evidence (6-8) suggests that distinct alkalosis occasionally arises as a metabolic concomitant of hypertension.CASE REPORTA...References1. HOLLANDERCHOBANIANBURROWS WAVBA: Body fluid and electrolyte composition in arterial hypertension. I. Studies in essential, renal and malignant hypertension. J. Clin. Invest. 40: 408, 1961. CrossrefMedlineGoogle Scholar2. LARAGHULICKJANUSZEWICZKELLYLIEBERMAN JHSVWGS: Electrolyte metabolism and aldosterone secretion in benign and malignant hypertension. Ann. Intern. Med. 53: 259, 1960. LinkGoogle Scholar3. VENNINGDYRENFURTHDOSSITORBECK EHIJBJC: Essential hypertension and aldosterone. Circulation 23: 168, 1961. CrossrefMedlineGoogle Scholar4. GARSTSHUMWAYSCHWARTZFARRELL JBNPHGL: Aldosterone excretion in essential hypertension. J. Clin. Endocr. 20: 1351, 1960. 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Author, Article, and Disclosure InformationAffiliations: Iowa City, IowaFrom the Medical Service, Veterans Administration Hospital and Department of Internal Medicine, College of Medicine, State University of Iowa, Iowa City, Iowa.Presented at the Midwest Regional Meeting of the American College of Physicians, Chicago, Illinois, September 16, 1961.Requests for reprints should be addressed to Mark L. Armstrong, M.D., Veterans Administration Hospital, Iowa City, Iowa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByProgress in the Diagnosis of Secondary HypertensionPlasma Vasoconstrictor Activity in Patients with Renal, Malignant, and Primary Hypertension 1 February 1963Volume 58, Issue 2Page: 336-340KeywordsAldosteroneDrug administrationDrugsExcretionHeart failureHospital medicineHypertensionMedical servicesProteinuriaUrea Issue Published: 1 February 1963 PDF DownloadLoading ...