tbuckley/cabot-search huggingface dataset:
Impaired Rate of Left Ventricular Filling in Idiopathic Hypertrophic Subaortic Stenosis and Valvular Aortic Stenosis
Authors: SCOTT STEWART, DEAN T. MASON, EUGENE BRAUNWALD
Journal: Circulation (1968)

In order to determine whether there is any interference with left atrial emptying or left ventricular filling in idiopathic hypertrophic subaortic stenosis (IHSS) and aortic stenosis, the fall in pressure (y descent) of the left atrial v wave following the opening of the mitral valve was analyzed in 27 patients with IHSS and in 22 patients with valvular aortic stenosis, and the results were compared to those for 13 normal subjects and 24 patients with mitral stenosis. The y descent in 0.1 sec and the mean rate of the y descent, as well as the maximum rate of decline, were reduced in all three groups of patients, as compared to those of the normal group. The changes in IHSS were more marked than those occurring in patients with aortic stenosis or mitral stenosis. These findings in patients with IHSS and valvular aortic stenosis appear to result from reduced left ventricular compliance. It is concluded that there is an impairment of left ventricular filling in IHSS and that obstruction to ventricular inflow, as well as to outflow, contributes to the hemodynamic changes in this condition.
The Genetic and Environmental Contributions to Autism
Authors: Diana E. Schendel, Therese K. Grønborg, Erik T. Parner
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WEIGHT AT BIRTH
Authors: J. D'Ewart
Journal: BMJ (1928)

<b>2520</b> <h3><b>Objectives</b></h3> Tracer activity concentrations in tissues are often used in disease evaluation by way of standard uptake values (SUV’s). However, the partial volume effects associated with finite resolutions of PET/TC scanners can result in severe loss of counts of small size regions. In this research project, we empirically calculated the correction coefficients for the partial volume effects of a PET/CT scanner. <h3><b>Methods</b></h3> An American College of Radiology PET/CT phantom with cylinders diameter sizes of 25, 16, 12 and 8 mm was scanned six (6) times with activity concentrations of 30.8, 17.8, 10.4, 8.1, 6.6 and 5.2 kBq/mL. All scans were acquired on a GE Discovery STE 16 slices in 3D mode and time duration of 4 min. each. The PET/CT axial images were used to obtain the tracer activity concentrations by drawing regions of interest (ROI’s) around each activity area. All activity concentrations obtained from the scans were then decay corrected to the original concentrations obtained from the well counter. The ROI’s data from each cylinder at specific times were then averaged and analyzed. <h3><b>Results</b></h3> The activity concentration losses (mean ± SD) for the 25, 16, 12 and 8 mm cylinders diameter sizes were 18.9 ± 3.6%, 30.8 ± 5.9%, 48.2 ± 5.6% and 69.4 ± 4.7%, respectively. For this particular scanner, the correction coefficients for partial volume effects of area sizes of 25, 16, 12 and 8 mm were 1.2, 1.4, 1.9, and 3.3, respectively. <h3><b>Conclusions</b></h3> For better accuracy of tumors evaluations when SUV’s are uesd, empirical correction factors for PET/CT scanners due to partial volume effects should be obtained, as shown through this experiment, and applied according to the tumor sizes.
The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-κB positive feedback loop in peripheral T-cell lymphoma
Authors: Rebecca L. Boddicker, N. Sertac Kip, Xiaoming Xing, Yu Zeng, Zhi-Zhang Yang, Jeong-Heon Lee, Luciana L. Almada, Sherine F. Elsawa, Ryan A. Knudson, Mark E. Law, Rhett P. Ketterling, Julie M. Cunningham, Yanhong Wu, Matthew J. Maurer, Megan M. O’Byrne, James R. Cerhan, Susan L. Slager, Brian K. Link, Julie C. Porcher, Deanna M. Grote, Diane F. Jelinek, Ahmet Dogan, Stephen M. Ansell, Martin E. Fernandez-Zapico, Andrew L. Feldman
Journal: Blood (2015)
Making It From Home to First
Authors: Lawrence J. Hergott
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Book Review Euthanasia: Toward an ethical social policy By David C. Thomasma and Glenn C. Graber. 302 pp. New York, Continuum, 1990. $24.95. Drawing the Line: Life, death, and ethical choices in an American hospital By Samuel Gorovitz. 195 pp. New York, Oxford University Press, 1991. $19.95.
Authors: Susan S. Mattingly
Journal: New England Journal of Medicine (1991)
Diffuse Cutaneous mastocytosis, 22 years on
Authors: W.E. Beer, E.S. Emslie, M. Huges
Journal: British Journal of Dermatology (1990)

Journal Article Diffuse Cutaneous mastocytosis, 22 years on Get access W.E. Beer, W.E. Beer Departments of Dermatology and Pathology, Gwynedd District General Hospital, Bangor, Gwynedd LL57 2PW, U. K. Search for other works by this author on: Oxford Academic Google Scholar E.S. Emslie, E.S. Emslie Departments of Dermatology and Pathology, Gwynedd District General Hospital, Bangor, Gwynedd LL57 2PW, U. K. Search for other works by this author on: Oxford Academic Google Scholar M. Huges M. Huges Departments of Dermatology and Pathology, Gwynedd District General Hospital, Bangor, Gwynedd LL57 2PW, U. K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 122, Issue 4, 1 April 1990, Pages 571–572, https://doi.org/10.1111/j.1365-2133.1990.tb14738.x Published: 01 April 1990
Use of the herpes amplicon system as a vehicle for somatic gene transfer
Authors: Andrew I Brooks, Marc W Halterman, Howard J Federoff
Journal: Advanced Drug Delivery Reviews (1997)

The study of herpes virus biology has produced two vector delivery strategies which exploit the highly evolved neuronal tropism and life cycle regulation exhibited by this class of viruses. Amplicon and recombinant herpes simplex virus systems show promise for use in gene transfer to the nervous system and although neither vector has been used in clinical trials to date, their application to gene delivery and perturbation of neuronal physiology have been well established. We will review the properties of the herpes amplicon system, and demonstrate its utility in neuroscience applications.
A Phase I Study of EKB-569 in Combination with Capecitabine in Patients with Advanced Colorectal Cancer
Authors: Dan Laheru, Gary Croghan, Ronald Bukowski, Michelle Rudek, Wells Messersmith, Charles Erlichman, Robert Pelley, Antonio Jimeno, Ross Donehower, Joseph Boni, Richat Abbas, Patricia Martins, Charles Zacharchuk, Manuel Hidalgo
Journal: Clinical Cancer Research (2008)

To determine the maximum tolerated dose (MTD), characterize the principal toxicities, and assess the pharmacokinetics of EKB-569, an oral selective irreversible inhibitor of the epidermal growth factor receptor tyrosine kinase, in combination with capecitabine in patients with advanced colorectal cancer.Patients were treated with EKB-569 daily for 21 days and capecitabine twice daily for 14 days of a 21-day cycle. The dose levels of EKB-569 (mg/day) and capecitabine (mg/m(2) twice daily) assessed were 25/750, 50/750, 50/1,000 and 75/1,000. An expanded cohort was enrolled at the MTD to better study toxicity and efficacy. Samples of plasma were collected to characterize the pharmacokinetics of the agents. Treatment efficacy was assessed every other cycle.A total of 37 patients, the majority of whom had prior chemotherapy, received a total of 163 cycles of treatment. Twenty patients were treated at the MTD, 50 mg EKB-569, daily and 1,000 mg/m(2) capecitabine twice daily. Dose-limiting toxicities were diarrhea and rash. No patients had complete or partial responses but 48% had stable disease. The conversion of capecitabine to 5-fluorouracil was higher for the combination of EKB-569 and capecitabine (321+/-151 ng*h/mL) than for capecitabine alone (176+/-62 ng*hours/mL; P=0.0037).In advanced colorectal cancer, 50 mg EKB-569 daily can be safely combined with 1,000 mg/m(2) capecitabine twice a day. A statistically significant increase in plasma levels of 5-fluorouracil for the combination of EKB-569 and capecitabine may be due to the single-dose versus multiple-dose exposure difference, variability in exposure or a potential drug interaction.
In-111 Labeled Leukocyte Scintigraphy of Infected Prosthesis With Candida Palapsilosis in a Patient Without Predisposing Risk Factors
Authors: SEIGO KINUYA, KUNIHIKO YOKOYAMA, KAZUHITO HAJI, SHOTA KONISHI, EUI-HYO HWANG, TAKATOSHI MICHIGISHI, NORIHISA TONAMI
Journal: Clinical Nuclear Medicine (1996)

Candida infection after prosthetic arthroplasty is an extremely rare complication manifested by an indolent course and the suspicion of candida isolation as a culture contaminant, which make the diagnosis difficult. A knee prosthesis infected with candida palapsilosis in a 50-year-old woman without predisposing risk factors was clearly delineated by In-111 labeled leukocyte scintigraphy. With positive leukocyte scintigraphy, misinterpretation of the positive isolation of candida may be avoided and, thus, proper treatment may start at an early stage.
Splenectomy for thrombocytopenia in chronic lymphocytic leukemia
Authors: Stuart A. Merl, Michael E. Theodorakis, Jack Goldberg, Arlan J. Gottlieb
Journal: American Journal of Hematology (1983)

Abstract The role of peripheral platelet destruction as a reversible etiology of thrombocytopenia in chronic lymphocytic leukemia (CLL) was evaluated in nine patients with CLL and refractory thrombocytopenia who underwent splenectomy. The patients' ages ranged from 54 to 74 years. Progressive thrombocytopenia refractory to antineoplastic agents and corticosteroids had been present for a mean of 23.4 months. The platelet counts were 4,000–57,000/μl, and were generally higher in those patients with larger spleens. The spleens ranged from 180 to 4050 gm. Seven patients responded completely to splenectomy, achieving platelet counts &gt; 150,000/μl, and in one other patient, the count rose to &gt; 100,000/μl. The platelet count of one patient failed to respond to surgery. Those patients with massive splenomegaly developed higher, more rapidly rising platelet counts postoperatively. No operative mortality was encountered. Median hospitalization was seven postoperative days. All patients experienced an increased sense of well‐being. Median follow‐up time is 9 months.
Treatment of Children and Young Adults with Early-Stage Non-Hodgkin's Lymphoma
Authors: Michael P. Link, Jonathan J. Shuster, Sarah S. Donaldson, Costan W. Berard, Sharon B. Murphy
Journal: New England Journal of Medicine (1997)

Children and young adults with early-stage non-Hodgkin's lymphoma have an excellent prognosis, but treatment is prolonged and is associated with many side effects. We performed two studies to determine whether therapy could be simplified.
438 Continued safety and efficacy of adding adefovir dipivoxil (ADV) to ongoing lamivudine (LAM) therapy in compensated chronic hepatitis B (CHB) patients with YMDD variant HBV: 2 year results
Authors: R. Perrillo, B. Willems, N. Leung, C. Trepo, H.W.L. Hann, G. Lau, W.M. Lee, E. Schiff, T. Wright, S. Scott, M. Woessner, C.L. Brosgart, S. Gardner
Journal: Journal of Hepatology (2004)
Mortality after hip and knee replacement has halved since 2003
Authors: Z. Kmietowicz
Journal: BMJ (2014)

Mortality after hip and knee replacement surgery in England, Wales, and Northern Ireland has halved in the eight years since 2003, an audit has shown.

Figures from the National Joint Registry annual report showed that 205 686 hip, knee, ankle, elbow, and shoulder joint replacements were carried out in 2013.1 The registry holds data on more than 1.6 million cases of joint replacement, which it has been collecting since 2003. The data showed that 90 day mortality rates after hip replacement fell from 0.56% in 2003 to 0.29% in 2011 and that 45 day mortality rates after …
jMOSAiCS: joint analysis of multiple ChIP-seq datasets
Authors: Xin Zeng, Rajendran Sanalkumar, Emery H Bresnick, Hongda Li, Qiang Chang, Sündüz Keleş
Journal: Genome biology (2013)

The ChIP-seq technique enables genome-wide mapping of in vivo protein-DNA interactions and chromatin states. Current analytical approaches for ChIP-seq analysis are largely geared towards single-sample investigations, and have limited applicability in comparative settings that aim to identify combinatorial patterns of enrichment across multiple datasets. We describe a novel probabilistic method, jMOSAiCS, for jointly analyzing multiple ChIP-seq datasets. We demonstrate its usefulness with a wide range of data-driven computational experiments and with a case study of histone modifications on GATA1-occupied segments during erythroid differentiation. jMOSAiCS is open source software and can be downloaded from Bioconductor 1.
SKIN TESTS IN PATIENTS WITH ASTHMA
Authors: JAMES S. McLAUGHLIN
Journal: JAMA (1927)

A cutaneous reaction in a hypersensitive individual was first discovered by Blackley in 1873. This important discovery, neglected by the profession for the next forty years, was revived about fifteen years ago and placed on a firm clinical basis by Cooke, Walker and others. It is based on the fact that those substances which, when inhaled or taken into the body by some other means, are capable of producing asthma will also produce an urticarial wheal when brought into contact with the lower layers of the epidermis. This report covers such tests performed in the Asthma Clinic of the Jefferson Hospital and in private practice for the last six years. All asthma patients coming to the clinic are tested as a matter of routine with about twenty-four different substances. Some new ones were added and some old ones, whose importance was not great, have been dropped from time to time.
Where next for lung cancer gene expression profiling?
Authors: S. M. Janes, F. McCaughan
Journal: European Respiratory Journal (2007)

Biological understanding of lung cancer lags behind that of other tumours. The reasons for this are both biological and social. Lung cancer is largely derived from exposure to carcinogens in tobacco smoke. This leaves lung epithelium with a multitude of somatic chromosomal mutations, deletions and amplifications, and hence a multitude of possible target genes to study and understand. This is before the different cell types resident within the lung and the subsequent cancer subgroups are considered 1. Unfortunately, research into this disease is also grossly under funded; and with the social vilification of smokers and accepting nihilism of doctors and patients alike, things are slow to change. However, up to 20% of lung cancers worldwide are in nonsmokers, and with an increasing proportion of lung cancer occurring in ex-smokers, lobby groups are strengthening.

It is a huge challenge with the disrupted cancer genome to disentangle the critical or “driver” somatic changes in a cancer cell from the bystander changes of little biological impact. One way this has been addressed is by using modern array technology to examine the cancer genome (DNA) or transcriptome (mRNA). Such studies aim to define common signatures shared between tumours of the same type. It can be inferred that consistent significant biological changes within a specific tumour type are of functional significance and may represent suitable targets for therapeutic manipulation. Another goal of array-based data is to distinguish tumours of varying prognosis and ultimately to use this information to guide therapy.

In the current issue of the European Respiratory Journal , Larsen et al . 2 have used gene expression array technology to understand why cancers of a similar stage appear to behave so differently. Their focus is on N1 disease, which in …
Use of the Scintillation Anger Camera and Xenon Xe 133 in the Study of Chronic Obstructive Lung Disease
Authors: Jose R. Medina
Journal: JAMA (1969)

Pulmonary ventilation and perfusion were studied in 12 normal subjects and 40 patients with obstructive lung disease. Xenon Xe 133 and the scintillation Anger camera were used. Serial photographs were obtained after injection, inhalation, and washout of xenon Xe 133. The distribution of blood flow and ventilation was studied in these photographs. Normal subjects presented uniform distribution of perfusion and ventilation. Preferential blood flow to the bases was noted because the patients were in the upright position. Patients with severe, chronic, obstructive lung disease showed regions of poor ventilation with or without areas of impaired perfusion. The scintiphotographs were found to be a valuable addition to the study of regional lung function, since they permit identification and mapping of areas of impaired perfusion or of poor ventilation.
Serendipitous Detection of Metastatic Thyroid Cancer During I-123 Tc-99m Sestamibi Dual Parathyroid Imaging
Authors: Nataraj Shanmugam, William Johns, Kelly Chasse, Shiv M. Gupta
Journal: Clinical Nuclear Medicine (2005)

Dual isotope parathyroid imaging performed on a 47-year-old man with known papillary thyroid cancer and biochemical hyperparathyroidism showed residual concentration of sestamibi consistent with a right inferior parathyroid adenoma. Subsequent thyroidectomy and parathyroidectomy was performed. Histology revealed a left superior parathyroid adenoma and normal right inferior parathyroid gland. Right inferior parathyroid adenoma on scintigraphy was, in fact, a cervical lymph node metastasis from the papillary thyroid carcinoma.
Causes of Neonatal Mortality
Authors: Richard H. Raring
Journal: JAMA (1984)

<h3>To the Editor.—</h3> In his letter, "Causes of Neonatal Mortality," Bader<sup>1</sup>displays data (Table 2) that contain a remarkable finding, in addition to his findings that relate to the role of lethal congenital anomalies in infant mortality but on which his letter does not remark. Specifically, his additional finding is the relationship between birth weight and postneonatal sudden infant death syndrome (SIDS). Of the 690 postneonatal deaths of infants with birth weights of 2,500 g or greater, 59.1% were caused by SIDS. The corresponding SIDS percentages of postneonatal deaths of infants with birth weights of 1,500 to 2,499 g and less than 1,500 g were 48.3% and 27.8%, respectively. (The "&lt;500 g" datum of column 1, line 2 of Table 2 is surely a typographic error.) Bader's data appear to be in conflict with pronouncements by many SIDS researchers, viz, that infants of higher birth weights are at less
The pancreatic β cell: recent insights from human genetics
Authors: Soren K. Thomsen, Anna L. Gloyn
Journal: Trends in Endocrinology and Metabolism (2014)

Diabetes mellitus is a metabolic disease characterised by relative or absolute pancreatic β cell dysfunction. Genetic variants implicated in disease risk can be identified by studying affected individuals. To understand the mechanisms driving genetic associations, variants must be translated through causative transcripts to biological insights. Studies into the genetic basis of Mendelian forms of diabetes have successfully identified genes involved in both β cell function and pancreatic development. For type 2 diabetes (T2D), genome-wide association studies (GWASs) are uncovering an ever-increasing number of susceptibility variants that exert their effect through β cell dysfunction, but translation to mechanistic understanding has in most cases been slow. Improved annotations of the islet genome and advances in whole-genome and -exome sequencing (WHS and WES) have facilitated recent progress.
Heterozygous frameshift mutation in keratin 5 in a family with <scp>G</scp> alli– <scp>G</scp> alli disease
Authors: A.K. Reisenauer, S.V. Wordingham, J. York, E.W.J. Kokkonen, W.H.I. Mclean, N.J. Wilson, F.J.D. Smith
Journal: British Journal of Dermatology (2013)

Reticulate pigmentary disorders include the rare autosomal dominant Galli-Galli disease (GGD) and Dowling-Degos disease (DDD). Clinical diagnosis between some of the subtypes can be difficult due to a degree of overlap between clinical features, therefore analysis at the molecular level may be necessary to confirm the diagnosis.To identify the underlying genetic defect in a 48-year-old Asian-American woman with a clinical diagnosis of GGD.Histological analysis was performed on a skin biopsy using haematoxylin-eosin staining. KRT5 (the gene encoding keratin 5) was amplified from genomic DNA and directly sequenced.The patient had a history of pruritus and hyperpigmented erythematous macules and thin papules along the flexor surfaces of her arms, her upper back and neck, axillae and inframammary areas. Hypopigmented macules were seen among the hyperpigmentation. A heterozygous 1-bp insertion mutation in KRT5 (c.38dupG; p.Ser14GlnfsTer3) was identified in the proband. This mutation occurs within the head domain of the keratin 5 protein leading to a frameshift and premature stop codon.From the histological findings and mutation analysis the individual was identified as having GGD due to haploinsufficiency of keratin 5.