tbuckley/cabot-search huggingface dataset:
Prospective study of early rheumatoid arthritis. II. Association of rheumatoid factor isotypes with fluctuations in disease activity.
Authors: R H Withrington, I Teitsson, H Valdimarsson, M H Seifert
Journal: Annals of the Rheumatic Diseases (1984)

Thirty-three patients with early peripheral synovitis were followed up for two to four years in order to study the relationship between fluctuations in rheumatoid factor (RF) levels and indices of clinical activity.Twenty-eight of these patients developed classical/definite rheumatoid arthritis (RA).Seventeen patients developed erosive disease of their hands and wrists and thirteen had a positive RF agglutination test.Nineteen patients had raised levels of IgM, RF, IgA, RF, or IgG RF as measured by isotype-specific ELISA techniques.The within-patient fluctuations in IgA RF levels correlated significantly with the corresponding fluctuations in grip strength (p<0-05), erythrocyte sedimentation rate (ESR) (p<0-01), and a composite index of disease activity (p<002).IgG RF levels were also associated with changes in ESR and grip strength, but IgM RF showed only a weak association with fluctuations in ESR and not with any other clinical parameters.It is suggested that serum IgA RF may be a useful marker of disease activity in rheumatoid arthritis.Rheumatoid factors (RF) of the agglutinating type occur in over 75% of rheumatoid arthritis (RA) patients,' and intracellular IgG RF complexes have been reported to be particularly prominent in synovial tissues from seronegative RA patients.2Thus, RFs are an immunological hallmark of RA and may be directly involved in the pathogenesis.34There is considerable uncertainty, however, as to the relationship between rheumatoid factors and clinical disease activity.Otten and Boerma5 found no close association between levels of agglutinating RF and disease activity and most authors are in agreement.Agglutinating RFs are predominantly of the IgM isotype but IgG RF and IgA RF are also known to occur,6 7 and recent progress in solid phase immunoassay techniques has enabled the development of isotype-specific RF assays.8 9The aim of this prospective study on early RA was to define more closely the relationship between
Antidepressant Treatment and Smoking Cessation in Bipolar Disorder
Authors: Alain Dervaux
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Case Management after Acute Myocardial Infarction
Authors: Robert F. DeBusk
Journal: Annals of Internal Medicine (1994)

Letters1 November 1994Case Management after Acute Myocardial InfarctionRobert F. DeBusk, MD, Nancy Houston Miller, RN, BSN, and C. Barr Taylor, MDRobert F. DeBusk, MDSearch for more papers by this author, Nancy Houston Miller, RN, BSNSearch for more papers by this author, and C. Barr Taylor, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-9-199411010-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate and agree with the comments of Drs. Alderman and Shenson regarding the complementary nature of nurse case management for prevention and physician management for acute illness. In our study, the nurse case-management system provided better preventive care than physicians provided alone. However, the authors interpreted our study as suggesting that the preventive care provided in this managed care organization was “wanting.” We disagree with this interpretation. The Kaiser-Permanente Medical Care Program has recognized the value of the improved care provided by the nurse case managers. Nurse case management has been incorporated into the routine preventive care ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byWomen and the global tobacco epidemic: nurses call to action 1 November 1994Volume 121, Issue 9Page: 720KeywordsAcute myocardial infarctionCardiovascular therapyForecastingNursesPatientsPreventive medicine Issue Published: 1 November 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation
Authors: Ying Taur, Robert R. Jenq, Miguel-Angel Perales, Eric R. Littmann, Sejal Morjaria, Lilan Ling, Daniel No, Asia Gobourne, Agnes Viale, Parastoo B. Dahi, Doris M. Ponce, Juliet N. Barker, Sergio Giralt, Marcel van den Brink, Eric G. Pamer
Journal: Blood (2014)
Insurance-Related Differences in the Risk of Ruptured Appendix
Authors: Paula Braveman, V. Mylo Schaaf, Susan Egerter, Trude Bennett, William Schecter
Journal: New England Journal of Medicine (1994)

We studied differences in the incidence of appendiceal perforation in patients with acute appendicitis according to their insurance coverage.In a retrospective analysis of hospital-discharge data, we examined the likelihood of ruptured appendix among adults 18 to 64 years old who were hospitalized for acute appendicitis in California from 1984 to 1989.After controlling for age, sex, psychiatric diagnoses, substance abuse, diabetes, poverty, race or ethnic group, and hospital characteristics, we found that ruptured appendix was more likely among both Medicaid-covered and uninsured patients with appendicitis than among patients with private capitated coverage (odds ratios, 1.49 [95 percent confidence interval, 1.41 to 1.59] and 1.46 [95 percent confidence interval, 1.39 to 1.54], respectively). After adjustment for the above factors, the risk of appendiceal rupture associated with a lack of private insurance was elevated at both county and other hospitals, but admission to a county hospital was an independent risk factor. In all income groups, appendiceal rupture was more likely with fee-for-service than capitated private coverage (overall odds ratio, 1.20 [95 percent confidence interval, 1.15 to 1.25]).Among patients with appendicitis an increased risk of ruptured appendix may be due to insurance-related delays in obtaining medical care. Both organizational and financial features of Medicaid and various types or levels of private third-party coverage may be involved. The significant association between ruptured appendix and insurance coverage after adjustment for socio-economic differences suggests barriers to receiving medically necessary acute care that should be considered in current deliberations on health policy.
Maintenance chrysotherapy in rheumatoid arthritis: a comparison of 2 dose schedules.
Authors: A J Griffin, T Gibson, G Huston, A Taylor
Journal: Annals of the Rheumatic Diseases (1981)

Maintenance treatment with chrysotherapy was given to 44 rheumatoid patients after a total of 1.0 g weekly injections of sodium aurothiomalate. 21 patients continued with 50 mg injections every 2 weeks, and 23 patients received the same dose at 4-week intervals. Their progress was followed over 1 year, after which time their clinical improvements were equally well sustained. Toxicity was greater in those patients receiving fortnightly injections. Five patients suffered a relapse after 8 months. These were not related to the frequency of injections nor to the serum gold levels. There appeared to be no advantage in maintenance injections at fortnightly intervals.
PHYSIOLOGIC OPTICS.NEW EXPERIMENTS FOR DEMONSTRATION AND NEW APPARATUS.
Authors: WINFIELD S. HALL
Journal: JAMA (1904)

When it was proposed to establish a laboratory course in the physiology of vision, the head of the department of ophthalmology was requested to state what he wished students to know in this field when they presented themselves in his department for clinical work on the eye. The reply was in effect this: Before the student can enter on the clinical study of the eye he should be acquainted with: the anatomy of the conjunctiva; the lachrymal apparatus, including the drainage and the extrinsic muscles; the circulation, extrinsic and intrinsic; the nerve supply of the muscles, the mechanism of muscle action, the gross and minute anatomy of the coats of the eyeball; the refractive media, the retinal circulation, and the ciliary apparatus. He should thoroughly understand the functions of all the parts studied. The student can not hope to succeed in clinical ophthalmology unless he has a clear understanding of
Representation of authors and editors from poor countries: Observed publication bias may reflect who is funding research
Authors: Ranjit Manchanda, Rajesh Varma
Journal: BMJ (2004)

Editor-Despite research in tropical medicine being undertaken in countries from low human development index, authorship and editorial opinion remain with countries from higher development index.This unfair trend observed by Keiser et al demands to be addressed and overturned. 1 This observed bias may arise because countries of high human development index fund the bulk of research in tropical medicine. 2 3Authors from these countries have prepared the grant applications, taken principal investigator status, and believe that they should take primary or terminal authorship.Researchers from low human development index countries can break this cycle only if they can obtain international funding themselves or are allowed authorship by the principal investigators.It seems this is rarely extended to the collaborators in tropical countries, even though they are the ones practically conducting the study.If such generosity in authorship and mentorship were provided, this would enable researchers from low human devel-
CARDIAC REMODELING AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION
Authors: Simon Biner, Yan Topilsky, Yoav Michowitz, Shmuel Banai, Gad Keren, Arie Steinvil, Eran Leshem-Rubinow, Ariel Finkelstein
Journal: Journal of the American College of Cardiology (2013)
A National School of Tropical Medicine.
Authors: Albert L. Bennett
Journal: JAMA (1899)

St. Anne, Ill., July 15, 1899. <h3>To the Editor.</h3> —With the "Stars and Stripes" flying over the Hawaiian Islands and our new possessions abroad since the termination of the war with Spain, has not the time arrived for a more thorough and systematic teaching in our medical schools of the etiology, pathology, symptoms and treatment of tropical diseases? Returning from the west coast of Africa, last April, I was delighted to learn of the energy being displayed by the Liverpool School of Tropical Diseases, and knowing, from personal experience, what a terrible havoc malarial fever causes among the white settlers in western and equatorial Africa, and realizing how the troops and citizens in our new possessions will have to face not malaria alone, but other diseases peculiar to warm climates, I venture to advocate a more thorough course in all diseases pertaining to the tropics. Many of the future graduates
Therapeutic Innovations, Diminishing Returns, and Control Rate Preservation
Authors: David M. Kent
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rheumatoid arthritis: effects of a new agent (ICI 55 897) on serum acute phase proteins and the erythrocyte sedimentation rate.
Authors: B McConkey, R S Amos, M E Billingham, T J Constable, R A Crockson, A P Crockson, P J Forster
Journal: Annals of the Rheumatic Diseases (1980)

Thirty-four patients with rheumatoid arthritis (RA) were treated with a new agent (ICI 55 897) in addition to basic therapy with nonsteroid anti-inflammatory drugs. Five patients had the drug for less than 28 days; the remaining 29 were observed for periods up to a year. At 140 days, when all but 2 patients were in the study, there had been statistically significant improvement in clinical score, serum C-reactive protein, erythrocyte sedimentation rate, and plasma fibrinogen. Thereafter results continued to improve but were biased because some patients had stopped taking the drug. The final conclusion was that 17 patients had improved with 1 late relapse, and 15 had not responded. Adverse effects were trivial except in 2 instances: one patient had a transient unexplained rise in blood urea, another had a haematemesis. Neither effect could be attributed with certainty to the drug. ICI 55 897 has no intrinsic analgesic or anti-inflammatory properties. We suggest the findings of this study indicate that this agent, with low toxicity and the ability to lower acute-phase protein levels, may be an alternative to gold or penicillamine in the treatment of RA.
Mast Cells Can Amplify Airway Reactivity and Features of Chronic Inflammation in an Asthma Model in Mice
Authors: Cara M.M. Williams, Stephen J. Galli
Journal: The Journal of Experimental Medicine (2000)

The importance of mast cells in the development of the allergen-induced airway hyperreactivity and inflammation associated with asthma remains controversial. We found that genetically mast cell–deficient WBB6F1-W/Wv mice that were sensitized to ovalbumin (OVA) without adjuvant, then challenged repetitively with antigen intranasally, exhibited much weaker responses in terms of bronchial hyperreactivity to aerosolized methacholine, lung tissue eosinophil infiltration, and numbers of proliferating cells within the airway epithelium than did identically treated WBB6F1-+/+ normal mice. However, W/Wv mice that had undergone selective reconstitution of tissue mast cells with in vitro–derived mast cells of congenic +/+ mouse origin exhibited airway responses that were very similar to those of the +/+ mice. By contrast, W/Wv mice that were sensitized with OVA emulsified in alum and challenged with aerosolized OVA exhibited levels of airway hyperreactivity and lung tissue eosinophil infiltration that were similar to those of the corresponding +/+ mice. Nevertheless, these W/Wv mice exhibited significantly fewer proliferating cells within the airway epithelium than did identically treated +/+ mice. These results show that, depending on the “asthma model” investigated, mast cells can either have a critical role in, or not be essential for, multiple features of allergic airway responses in mice.
A rare fracture-dislocation of the hip in a gymnast and review of the literature
Authors: J C Mitchell, P V Giannoudis, P A Millner, R M Smith
Journal: British Journal of Sports Medicine (1999)

Posterior fracture-dislocation of the hip is an uncommon injury in athletics and leisure activities. It is more commonly seen in high energy motor vehicle accidents and occasionally in high energy sporting activities. A rare case is reported of posterior fracture-dislocation of the hip joint that occurred in a young athlete during gymnastics. This unusual mechanism of injury illustrates the great forces sustained by the hip joint of gymnasts. Early reduction and operative treatment led to a congruent and stable hip joint. After rehabilitation, she returned to light sporting activities after six months.
Vasomotor Tone in Diabetic Neuropathy
Authors: SANDOR A. FRIEDMAN,
Journal: Annals of Internal Medicine (1972)

Peripheral vasoconstriction capacity was studied in 19 patients with diabetic neuropathy, with the use of a well-insulated constant-temperature room. Vasomotor tone was totally absent in only one patient. Six patients had orthostatic hypotension with normal vasomotor tone, and seven patients had diabetic osteopathy. We concluded that adrenergic sympathetic function is usually preserved in the lower extremities, even in severe diabetic neuropathy.
Postmyelographic lateral rectus palsy associated with iopamidol.
Authors: J A Bell, G G McIlwaine
Journal: BMJ (1990)

None the less, the paper does give some cause for optimism.Its authorship, from both medicine and personnel management, may reflect a new recognition that local solutions are more likely to come from cooperation than confrontation.It provides rare data to add to the continuing debate on what doctors actually do, and it notes (although, revealingly, no comment is made) that the ad- mitting house physician does not go to bed for 34 hours.Let us hope it is read by Mrs Bottomley and her working party.
Acute Episode of Raynaud's Disease
Authors: Marsha J Bluto, Daniel A Norman
Journal: New England Journal of Medicine (2002)

Figure 1. A 54-year-old man had an acute primary episode of Raynaud's disease after surfing for 80 minutes in water that was 21°C. The distinctive asymmetric pallor of the terminal phalanges of the fourth digit on the right hand persisted for 40 minutes. A sharp demarcation between the second and third phalangeal joints was evident, but no other symptoms were apparent. The pallor spontaneously resolved without cyanosis or redness of the affected area. Medical evaluation subsequently revealed no disorder known to cause secondary Raynaud's phenomenon. Raynaud's phenomenon is manifested by episodes of pallor and cyanosis of the digits in response . . .
Relationship between electrode geometry and effectiveness of ventricular defibrillation in the dog with catheter having one electrode in right ventricle and other electrode in superior vena cava, or external jugular vein, or both
Authors: J. C. SCHUDER, H. STOECKLE, J. A. WEST, P. Y. KESKAR
Journal: Cardiovascular Research (1973)

Journal Article Relationship between electrode geometry and effectiveness of ventricular defibrillation in the dog with catheter having one electrode in right ventricle and other electrode in superior vena cava, or external jugular vein, or both Get access JOHN C. SCHUDER, JOHN C. SCHUDER 2 From the Section of Thoracic and Cardiovascular Surgery, Department of Surgery and Department of Pediatrics, University of Missouri, Columbia, U.S.A. 2Correspondence to: Dr. John C. Schuder, Department of Surgery, University of Missouri, Columbia, Missouri 65201, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar HARRY STOECKLE, HARRY STOECKLE From the Section of Thoracic and Cardiovascular Surgery, Department of Surgery and Department of Pediatrics, University of Missouri, Columbia, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar JOE A. WEST, JOE A. WEST From the Section of Thoracic and Cardiovascular Surgery, Department of Surgery and Department of Pediatrics, University of Missouri, Columbia, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar PRABHAKAR Y. KESKAR PRABHAKAR Y. KESKAR From the Section of Thoracic and Cardiovascular Surgery, Department of Surgery and Department of Pediatrics, University of Missouri, Columbia, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 7, Issue 5, September 1973, Pages 629–637, https://doi.org/10.1093/cvr/7.5.629 Published: 01 September 1973
Comparison of viral replication fitness of wild-type and lamivudine-resistant HBV in patients
Authors: W.E. Delaney, C. Westland, H. Yang, H. Namini, V. Thibault, Y. Benhamou, J. Fry, C. Brosgart, C. Gibbs, M. Miller, S. Xiong
Journal: Journal of Hepatology (2003)
Childhood obesity increases blood pressure in adolescence, study shows
Authors: S. Mayor
Journal: BMJ (2012)

Children who are overweight or obese throughout childhood show raised blood pressure at the age of 14, a new study has found.

Australian researchers followed up 1186 children from birth, plotting their level of obesity against reference standards on percentile charts from birth to 14 years. Children in the top third of weight for height charts from birth had systolic blood pressures that were 4-9 mm Hg higher at the age of 14 than those of children of average adiposity on a reference trajectory.

“By following this group of children from birth to …
Lack of effect of bretylium tosylate on electrical ventricular defibrillation in a controlled study
Authors: C. C. KOO, J D. ALLEN, J F. PANTRIDGE
Journal: Cardiovascular Research (1984)

Journal Article Lack of effect of bretylium tosylate on electrical ventricular defibrillation in a controlled study Get access CHEE CHOONG KOO, CHEE CHOONG KOO From the Departments of Cardiology and Physiology, The Royal Victoria Hospital and the Queen' s University of Belfast, N Ireland Search for other works by this author on: Oxford Academic PubMed Google Scholar J DESMOND ALLEN, J DESMOND ALLEN † From the Departments of Cardiology and Physiology, The Royal Victoria Hospital and the Queen' s University of Belfast, N Ireland †Correspondence and reprint requests to: J D Allen, MD, Physiology Department, The Queen's University of Belfast. Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, N Ireland. Search for other works by this author on: Oxford Academic PubMed Google Scholar J FRANK PANTRIDGE J FRANK PANTRIDGE From the Departments of Cardiology and Physiology, The Royal Victoria Hospital and the Queen' s University of Belfast, N Ireland Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 18, Issue 12, December 1984, Pages 762–767, https://doi.org/10.1093/cvr/18.12.762 Published: 01 December 1984