tbuckley/cabot-search huggingface dataset:
Assault after ingestion of antidepressant.
Authors: P Sugarman, T Hughes
Journal: BMJ (1991)

Dobbs and Fleming have succeeded in using history, symptoms, and dipstick tests to distinguish between the "urethral syndrome" and urinary infection where many others have failed.9However, our own experience with these criteria has been disappointing.Ditchburn and Ditchburn's use of microscopy9 is commendable, and we have also recommended it.However, some patients without significant bacteriuria have pyuria and some with significant bacteriuria have few if any leucocytes in their urine." Further, not all medical students are taught to use a microscope well enough to be able to recognise leucocytes in urine.Thus, the use of the microscope would require postgraduate training in many cases.
Viral link sought in juvenile diabetes
Authors: Phil Gunby
Journal: JAMA (1978)

Research in progress at the National Institutes of Health and elsewhere so far supports the suggestion that viruses are involved in the onset of diabetes mellitus in susceptible children. Viruses long have been suspect in juvenile diabetes. A hypothesis linking the disease with mumps myxovirus was formulated as early as 1864. But troublesome questions remain. For example, why has juvenile diabetes been relatively rare (only about one in ten cases of diabetes is of the juvenile type) when mumps—at least until arrival of the vaccine—has been comparatively common? Among those exploring possible links between viruses and diabetes are Abner Louis Notkins, MD, and co-workers in the Laboratory of Oral Medicine, National Institute of Dental Research (NIDR), Bethesda, Md. They now report evidence that mumps virus can infect and destroy pancreatic β cells cultured from human cadavers. However, at the American Diabetes Association's annual meeting in Boston, Dr Notkins emphasized that
Abstract 4924: Mucolytic drug N-Acetylcystein improves 89Zr-trastuzumab HER2-immunoPET imaging by restoring accessibility to HER2 hampered by membrane mucin overexpression in a HER2 positive MUC4 overexpressing xenograft mouse model
Authors: Zena Wimana, Geraldine Gebhart, Renato Morandini, Patrick Flamen, Ghanem Ghanem
Journal: Cancer Research (2014)

Abstract 89Zr-trastuzumab, a 89-Zirconium radiolabeled anti-HER2 monoclonal antibody, has been shown appropriate to enable positron emission tomography (PET) imaging of HER2 positive lesions in breast cancer (BC) patients. Binding of 89Zr-trastuzumab to the HER2 receptor, a prerequisite could be undermined by one of the postulated resistance mechanisms to trastuzumab, i.e. the interference of cell membrane glycoproteins mucins. This study aimed to assess whether mucolytic drug N-Acetylcystein (NAC) could enhance the uptake of 89Zr-trastuzumab in a HER2 positive and MUC4 overexpressing xenograft mouse model. Materials &amp; Methods: Trastuzumab was first coupled with the chelate N-succinyl-desferal ester, subsequently N-SucDF-trastuzumab was radiolabelled with 89Zr-oxalate in a HEPES buffered solution and purified by size exclusion chromatography. The impact of NAC on 89Zr-trastuzumab PET was studied in a dual model xenograft generated by s.c. inoculation of HER2+/MUC4- SKBr3 and JIMT1 HER2+/MUC4- BC cell lines, with the latter overexpressing MUC4. Mice were treated with NAC p.o. during 6 days. Body distribution and uptake of the tracer were measured 1) by in vivo PET/CT imaging and by 2)ex vivo tissue analysis. Results: In mice treated with NAC, there was a significant increase of the Standardized Uptake Value (SUV) mean, SUVmax and SUV Volume Histogram (SVH) in the MUC4 overexpressing tumors compared to the control group. This was not the case for MUC4 negative SKBR3 tumors. Furthermore, ex vivo body distribution data supported these results with a significant increase of radioactivity uptake in the MUC4 positive tumors and no change in non-tumoral tissues Conclusion: N-Acetylcysteine may be an interesting drug to improve the accessibility of trastuzumab to its receptors, HER2, by affecting mucin masking. Note: This abstract was not presented at the meeting. Citation Format: Zena Wimana, Geraldine Gebhart, Renato Morandini, Patrick Flamen, Ghanem Ghanem. Mucolytic drug N-Acetylcystein improves 89Zr-trastuzumab HER2-immunoPET imaging by restoring accessibility to HER2 hampered by membrane mucin overexpression in a HER2 positive MUC4 overexpressing xenograft mouse model. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4924. doi:10.1158/1538-7445.AM2014-4924
Persistence of Pneumocystis carinii in patients with AIDS receiving chemoprophylaxis.
Authors: L J Epstein, R D Meyer, S Antonson, S M Strigle, Z Mohsenifar
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Pneumocystis carinii organisms have been shown to persist throughout therapy in the majority of patients with Pneumocystis carinii pneumonia (PCP). This study evaluated the relationship between persistence of organisms and recurrence of disease, and the effect of chemoprophylaxis on bronchoalveolar lavage specimens. Seven patients receiving PCP chemoprophylaxis underwent serial bronchoalveolar lavage (BAL) examinations at 1, 4, and 7 mo after recovery from a first episode of PCP. Specimens were examined for persistent organisms with Gomori's methenamine silver stain and immunofluorescent antibody staining. There were no persistent organisms 1 mo after completion of antimicrobial treatment in six of the seven patients. The one patient with persistent organisms demonstrated clearance of organisms by 4 mo and had no recurrence of PCP. One patient had a recurrence of PCP at 4 mo, after a negative 1-mo BAL. We conclude that a positive BAL result by silver stain or immunofluorescent antibody staining more than a month after ending treatment may indicate clinical recurrence of PCP and not just persistence of nonpathologic cysts. These findings suggest that recurrences of PCP are more likely due to new infection than to relapse of prior disease.
Nippostrongylus brasiliensis infection in the rat: effect of iron and protein deficiency on the anthelmintic efficacy of mebendazole, pyrantel, piperazine, and levamisole.
Authors: V M Duncombe, T D Bolin, A E Davis, M R Fagan, J D Kelly
Journal: Gut (1979)

The benzimidazole anthelmintics mebendazole and fenbendazole have been shown to be much less effective against Nippostrongylus brasiliensis infections in the rat on a combined iron and protein deficient diet. In the present experiments it was shown that the anthelmintic efficacy of mebendazole was significantly impaired in the rat on either an iron deficient or a protein deficient diet. Furthermore, iron and protein deficiency reduced the efficacy of the anthelmintics pyrantel and piperazine but not levamisole. The finding that nutritional deficiencies reduce anthelmintic efficacy may well be relevant to worm eradication programmes in iron deficient and protein calorie malnourished populations.
Direct-to-Consumer Advertising — Strengthening Our Health Care System
Authors: Alan F. Holmer
Journal: New England Journal of Medicine (2002)

It has been almost five years since the Food and Drug Administration (FDA) issued guidelines clarifying the agency's broadcast requirements for the advertising of specific pharmaceutical agents directly to consumers on television.1 Previously, most direct-to-consumer advertising had been confined to newspapers and magazines. We think this expansion to television has been a positive step.Does direct-to-consumer advertising strengthen or weaken the physician–patient relationship? Physicians should and do remain in control of prescribing medicines. As the article by Rosenthal et al. in this issue of the Journal 2 makes clear, pharmaceutical companies recognize this fact by directing a large proportion of their . . .
NF-κB balances vascular regression and angiogenesis via chromatin remodeling and NFAT displacement
Authors: Arin B. Aurora, Dauren Biyashev, Yelena Mirochnik, Tetiana A. Zaichuk, Cristina Sánchez-Martinez, Marie-Ange Renault, Douglas Losordo, Olga V. Volpert
Journal: Blood (2010)
Abciximab modulates apoptosis of circulating neutrophils in patients with unstable angina
Authors: Antonino Buffon, Annalisa Porto, Giobanna Liuzzo, Antonella D'Annolfo, Donatella Lomaglio, Michela Pinnelli, Antonio G Rebuzzi, Attilio Maseri, Luigi M Biasucci, Filippo Crea
Journal: Journal of the American College of Cardiology (2003)
Tetracycline and Thyroid Function
Authors: Bernard J. Ficarra
Journal: JAMA (1967)

<h3>To the Editor:—</h3> The authors of "Tetracycline and Thyroid Function" have based their conclusions mainly on protein-bound iodine (PBI) and cholesterol levels (<b>199</b>: 416, 1967). Personal experience has led me to conclude that PBI studies are not entirely reliable because of the ease with which alterations in value can occur, as is known to every laboratory technologist. Cholesterol determinations are more valuable when they are performed with a simultaneous study of the cholesterol esters. The percentage evaluation between the two is a more effective determinant of physiological alterations than evaluation of cholesterol alone. As to the comparative Achilles tendon reflex, one must be a little cautious before accentuating its definitive value. There are many subclinical neuromuscular disorders which are overlooked very easily, and these incipient pathological entities may lull the examiner into a false state of security which may cause one to indict the thyroid gland for a physical sign
THE LONG PENTRAXIN 3 DID NOT PREDICT OUTCOME WITHIN 45 MONTHS FOLLOW-UP IN PATIENTS FOLLOWING A SEVERE MYOCARDIAL INFARCTION
Authors: Volker Pönitz, Heidi Grundt, Barbara Bottazzi, Ivan Cuccovillo, Alberto Mantovani, Dennis Nilsen
Journal: Journal of the American College of Cardiology (2013)
Chinese response to allergy and asthma in Olympic athletes
Authors: J. Li, Y. Lu, K. Huang, C. Wang, J. Lu, C. Zhang, N. Zhong
Journal: Allergy (2008)

China is going to host the Games of the XXIX Olympiad from 8–24 August 2008 in Beijing. The number of athletes and accompanying individuals expected to arrive at China for the Beijing Olympics is estimated at over 10 000 and among them at least 2 000 (20%) are suspected to suffer from respiratory allergies. It is important to monitor the pollen counts and improve air quality in Beijing because Olympic athletes would be exposed to airborne allergens and pollutants during competitions which could hinder peak performance. The main pollen and spore families in Beijing are Artemisia, Ambrosia, Chenopodiaceae and Gramineae. They can reach around 307 000 grains of pollen/1000 m 3 of air in August. Economic development in China is usually linked with worsening of air quality. Due to the adoption of various control measures, the ambient air quality in a number of areas in Beijing has actually improved. The ambient air TSP and SO 2 levels in Beijing have been decreasing in the last decade. However, ambient air NO x level has been increasing due to the increased number of motor vehicles. Nevertheless, dedicated medical facilities in Beijing will provide medical services to athletes and delegations from all over the world during the Beijing Olympic Games.
Diesel exhaust particulate induces airway hyperresponsiveness in a murine model: Essential role of GM-CSF☆☆☆
Authors: Ken Ohta, Naomi Yamashita, Makoto Tajima, Takashi Miyasaka, Junichi Nakano, Mikio Nakajima, Akira Ishii, Tadashi Horiuchi, Kenji Mano, Terumasa Miyamoto
Journal: Journal of Allergy and Clinical Immunology (1999)
Long-Term Survival After Cisplatin-Based Induction Chemotherapy and Radiotherapy for Nasopharyngeal Carcinoma: A Pooled Data Analysis of Two Phase III Trials
Authors: Daniel T.T. Chua, Jun Ma, Jonathan S.T. Sham, Hai-Qiang Mai, Damon T.K. Choy, Ming-Huang Hong, Tai-Xiang Lu, Hua-Qing Min
Journal: Journal of Clinical Oncology (2005)

Purpose To evaluate the long-term outcome in patients with nasopharyngeal carcinoma (NPC) treated with induction chemotherapy and radiotherapy (CRT) versus radiotherapy alone (RT). Patients and Methods The data from two phase III studies comparing CRT with RT in NPC were updated and pooled together for analysis. A total of 784 patients were included for analysis, with an equal number of patients in both arms. Induction chemotherapy consisted of two to three cycles of cisplatin, bleomycin, and fluorouracil, or cisplatin and epirubicin. RT was given to the nasopharynx and neck using megavoltage radiation (median dose, 70 Gy). The median follow-up time for surviving patients was 67 months. Analysis was based on intention to treat. Results The addition of induction chemotherapy to RT was associated with a decrease in relapse by 14.3% and cancer-related deaths by 12.9% at 5 years. The 5-year relapse-free survival rate was 50.9% and 42.7% in the CRT and RT arm, respectively (P = .014), and the 5-year disease-specific survival rate was 63.5% and 58.1% in the CRT and RT arm, respectively (P = .029). The 5-year overall survival rate was 61.9% and 58.1% in CRT and RT arm, respectively (P = .092). The incidence of locoregional failure and distant metastases was reduced by 18.3% and 13.3% at 5 years, respectively, with induction chemotherapy. There was no significant difference in the treatment failure patterns between the two arms. Conclusion The addition of cisplatin-based induction chemotherapy to RT was associated with a modest but significant decrease in relapse and improvement in disease-specific survival in advanced-stage NPC. However, there was no improvement in overall survival.
Case of Puerperal Tetanus, following Abortion and Plugging of the Vagina
Authors: J. Blackshaw
Journal: BMJ (1865)

Britith Medical Journal-3t ORIGINAL POX)t C. portion of the blood, that the practice of giving opium and other astringents, to arrest the intestinal discharges will continue more or less, in spite of W4re and disa~pointmeut,' until it can be clearly s1own that the state of collapse haa an entirely different origins and eause from that which the theory in question assumes.[To be continued.
Where Do We Really Stand With LESS and NOTES?
Authors: Matthew T. Gettman, Wesley M. White, Monish Aron, Riccardo Autorino, Tim Averch, Geoffrey Box, Jeffrey A. Cadeddu, David Canes, Edward Cherullo, Mihir M. Desai, Igor Frank, Indebir S. Gill, Mantu Gupta, Georges-Pascal Haber, Mitchell R. Humphreys, Brian H. Irwin, Jihad H. Kaouk, Louis R. Kavoussi, Jaime Landman, Evangelos N. Liatsikos, Estevao Lima, Lee E. Ponsky, Abhay Rane, Maria Ribal, Robert Rabenhalt, Pradeep Rao, Lee Richstone, Mark D. Sawyer, Rene Sotelo, Jens-Uwe Stolzenburg, Chad R. Tracy, Robert J. Stein
Journal: European Urology (2010)
Indium-111 autologous leucocyte scanning: comparison with radiology for imaging the colon in inflammatory bowel disease.
Authors: S H Saverymuttu, A M Peters, H J Hodgson, V S Chadwick, J P Lavender
Journal: BMJ (1982)

Indium-111 autologous leucocyte scanning was compared with barium enema for assessing the extent of colonic disease in Crohn9s colitis and ulcerative colitis. Scanning was shown to be as accurate as conventional radiology in colitis, reliably distinguishing active from inactive disease. The results suggest that 111In-leucocyte scanning is an accurate, non-invasive, alternative technique for imaging the extent of disease in colitis.
Abstract 468: Cancer cells with G/G mdm2 SNP309 have compromised transcriptional elongation of p53 target genes
Authors: Melissa Rosso, Alla Polotskaia, Jill Bargonetti
Journal: Cancer Research (2014)

Abstract MDM2 protein is often found over-expressed in cancers with wild-type p53. A single nucleotide polymorphism (T to G) near the mdm2 P2 promoter, mdm2 SNP309, leads to MDM2 overexpression. This polymorphism is associated with accelerated tumor formation, decreased sensitivity to DNA damage treatment and compromised p53 transcriptional activity. Two G/G SNP309 cell lines MANCA (Burkitt lymphoma) and A875 (melanoma) express wild-type p53 protein not readily degraded by MDM2. This wild-type p53 does not activate target genes even after DNA damage. During the blocked transcription, MDM2 and p53 co-localize at p53 response elements on chromatin. Therefore, we hypothesized that MDM2 localized with p53 on the chromatin was the contributing factor for the compromised p53 transcriptional activity. We explored the mechanism for compromised p53 transcriptional activity in these G/G SNP309 cancer cell lines. When compared to fully activated wild-type p53 in ML-1 cells treated with etoposide, MANCA and A875 cell lines had comparable recruitment of total and initiated RNA pol II at transcription start sites (TSS) for p21 and puma genes. This indicated that G/G SNP309 cells had functional transcription initiation at p53 target genes after DNA damage treatment. We next assessed epigenetic modifications associated with active transcriptional elongation. Using H3K36 trimethylation (H3K36me3) as a hallmark for active elongation, we observed that ML-1 cells had a substantial increase in H3K36me3 after etoposide treatment at p21 and puma TSS that was not seen in MANCA or A875 cell lines. This lack of H3K36me3 suggested an inhibition in early transcriptional elongation. To address the participation of MDM2 in the elongation block we created a stable MDM2 knockdown MANCA cell line. Interestingly, MDM2 knockdown drastically increased MDMX protein levels and moderately increased activation of p53 target genes implying MDMX played a redundant role for MDM2. We are currently investigating the roles of MDM2 and MDMX in blocking transcriptional elongation. Interestingly, we have found that treatment of MANCA cells with low dose Actinomycin D reactivates the p53 pathway and studies are in progress to determine if this is through activation of transcriptional elongation. This work was supported by The Breast Cancer Research Foundation and The National Science Foundation (grant MCB-0744316) to J.B. M.R. was supported by the MBRS-RISE Program to Hunter College 3R25-GM060665. Citation Format: Melissa Rosso, Alla Polotskaia, Jill Bargonetti. Cancer cells with G/G mdm2 SNP309 have compromised transcriptional elongation of p53 target genes. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 468. doi:10.1158/1538-7445.AM2014-468
Small-Intestinal Function in Vitamin B_12 Deficiency
Authors: JOHN LINDENBAUM
Journal: Annals of Internal Medicine (1974)

Intestinal function was studied in 28 patients with untreated pernicious anemia and no clinically apparent intestinal disease. The absorption of xylose was impaired in 29% of these patients; fat, in 9%; and vitamin B12 given with intrinsic factor, in 75%. Xylose malabsorption was more common in patients with severe hematologic depression; it was generally reversible within 2 to 3 weeks of beginning vitamin B12 therapy. In most patients cyanocobalamin absorption returned to normal within 1 to 8 weeks. In four patients cyanocobalamin absorption remained subnormal after 4 to 41 months of vitamin repletion. In two of these patients tetracycline therapy rapidly reversed the vitamin B12 malabsorption. The remaining two patients had high titers of serum antibodies to intrinsic factor. Reversible impairment of intestinal absorptive capacity is commonly associated with vitamin B12 deficiency. Abnormalities shown in absorption tests done within 2 months of initiating therapy in patients with pernicious anemia do not necessarily reflect primary small-intestinal disease.
Characterizing the Impact of Lymph Node Metastases on the Survival Outcome for Metastatic Renal Cell Carcinoma Patients Treated with Targeted Therapies
Authors: Nils Kroeger, Allan J. Pantuck, J. Connor Wells, Nicola Lawrence, Reuben Broom, Jenny J. Kim, Sandy Srinivas, Jessica Yim, Georg A. Bjarnason, Arnoud Templeton, Jennifer Knox, Ezra Bernstein, Martin Smoragiewicz, Jae Lee, Brian I. Rini, Ulka N. Vaishampayan, Lori A. Wood, Benoit Beuselinck, Frede Donskov, Toni K. Choueiri, Daniel Y. Heng
Journal: European Urology (2014)
Screening for carcinoma of the prostate.
Authors: D P Sandhu, C P Chilton, K W Munson
Journal: BMJ (1990)

based on only six patients have doubtful statistical significance and clinical relevance.Thus it is not surprising that the conclusions drawn by the authors are not supported in the existing literature.Indeed, there is a large body of data now available attesting to the long term safety of sphincterotomy in patients with intact gall bladders.'Furthermore, there is considerable evidence that sphincterotomy may enhance gall stone clearance from the gall bladder in animals and man.For example, dynamic scintigraphic studies using cholecystokinin in dogs have shown increased ejection fractions after sphincterotomy.'Safe and effective use of endoscopic sphincterotomy of the gall bladder in a wider population can be supported only by correctly designed controlled clinical trials.
Bullous Pemphigoid as Pruritus in the Elderly
Authors: Christiaan V. Bakker, Jorrit B. Terra, Hendri H. Pas, Marcel F. Jonkman
Journal: JAMA Dermatology (2013)

In the literature, patients with bullous pemphigoid have been reported to have itch without blisters. Clinical observations in these patients have varied from eczematous or urticarial to papular or nodular skin lesions. Here we investigated the spectrum of clinical variants.Fifteen patients with itch without blisters had immunopathologic findings of bullous pemphigoid. Mean age at diagnosis was 81.7 years. No blistering occurred during the mean 2.2 years of follow-up. Mean delay of diagnosis was 2.8 years. Clinical symptoms were heterogeneous: pruritus sine materia (no primary skin lesions), eczematous, urticarial, papular, and/or nodular skin lesions were seen. Treatment with potent topical corticosteroids or methotrexate sodium led to remission in 11 patients.Itch without skin lesions can be the only symptom of bullous pemphigoid. Therefore, it is important to include serologic and direct immunofluorescence in the diagnostic algorithm of itch. We propose the unifying term pruritic nonbullous pemphigoid for all patients with immunopathologic findings of bullous pemphigoid, itch, and no blisters.
IL-21 signalling via STAT3 primes human naïve B cells to respond to IL-2 to enhance their differentiation into plasmablasts
Authors: Lucinda J. Berglund, Danielle T. Avery, Cindy S. Ma, Leen Moens, Elissa K. Deenick, Jacinta Bustamante, Stephanie Boisson-Dupuis, Melanie Wong, Stephen Adelstein, Peter D. Arkwright, Rosa Bacchetta, Liliana Bezrodnik, Harjit Dadi, Chaim M. Roifman, David A. Fulcher, John B. Ziegler, Joanne M. Smart, Masao Kobayashi, Capucine Picard, Anne Durandy, Matthew C. Cook, Jean-Laurent Casanova, Gulbu Uzel, Stuart G. Tangye
Journal: Blood (2013)
Weathering nodules of the ear in a young woman
Authors: B. Amichai, J. Shiri
Journal: British Journal of Dermatology (1997)

Journal Article Weathering nodules of the ear in a young woman Get access B. Amichai, B. Amichai Department of Dermatology, Tel‐Nordoy Clinic, 1 Dov‐Hoz St, Tel Aviv, Israel Search for other works by this author on: Oxford Academic Google Scholar J. Shiri J. Shiri Department of Dermatology, Tel‐Nordoy Clinic, 1 Dov‐Hoz St, Tel Aviv, Israel Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 137, Issue 4, 1 October 1997, Page 659, https://doi.org/10.1111/j.1365-2133.1997.tb03816.x Published: 01 October 1997
Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice
Authors: XiuJie Li-Harms, Sandra Milasta, John Lynch, Christopher Wright, Aashish Joshi, Rekha Iyengar, Geoffrey Neale, Xi Wang, Yong-Dong Wang, Tomas A. Prolla, James E. Thompson, Joseph T. Opferman, Douglas R. Green, John Schuetz, Mondira Kundu
Journal: Blood (2014)