tbuckley/cabot-search huggingface dataset:
Chest Mass in a Patient With Gastric Cancer
Authors: Richard B. Bridenbaugh
Journal: JAMA (1985)

A 71-year-old woman was admitted to the hospital for gastric surgery. The preoperative diagnosis of adenocarcinoma of the stomach had previously been established by upper gastrointestinal tract examination followed by gastroscopy and biopsy. <h3>History</h3> The patient, in excellent health all her life, had an abdominal hysterectomy 25 years previously. Physical examination revealed no significant abnormality. An isotopic scan of the liver was normal. A chest roentgenogram demonstrated a mass in the posterior costophrenic angle on the right (Figs 1 and 2). Review of a chest film obtained six years previously showed no abnormality at that time. The characteristics of the mass were those of an extrapulmonic lesion. After evaluating the possibilities of a posterior mediastinal lesion, a diagnosis was made and presumptively confirmed by computed tomography (CT). <h3>Diagnosis</h3> Bochdalek's diaphragmatic hernia. The mass was considered to be extrapulmonic because of the stripelike areas of decreased density along the convexity of
The computational baby, the classical bathwater, and the middle way
Authors: Gerard O'Brien, Jon Opie
Journal: Behavioral and Brain Sciences (2002)

We are sympathetic with the broad aims of Perruchet &amp; Vinter's “mentalistic” framework. But it is implausible to claim, as they do, that human cognition can be understood without recourse to unconsciously represented information. In our view, this strategy forsakes the only available mechanistic understanding of intelligent behaviour. Our purpose here is to plot a course midway between the classical unconscious and Perruchet &amp;Vinter's own noncomputational associationism.
Letter: Effect of levodopa on Parkinsonian tremor.
Authors: G M Yuill
Journal: BMJ (1976)

lives and visits are often infrequent.To this extent, therefore, I see the community hospital in populations in excess of 40 000 being of primary significance to the community in respect of acute diagnostic and surgical services at an appropriate level, and the geriatric and long-stay element as a part of the overall picture rather than the pre- dominant feature.In populations less than this figure, however, then I would agree entirely with Dr Evans's comments about the role of community hospitals.This assumes that they can be viable in small communities, and this again is an area that, I would suggest, needs careful study in relation to the overall costs of these establishments set against the benefits to the community. KENNETH CLIFFWinchester Immunisation against whooping cough SIR,-In showing that 7500' of infants below 3 months of age with whooping cough were
Abstract 2414: Comparable effect of p53 peptide vaccine in adjuvant or pulsed on dendritic cells in ovarian cancer patients: A gynecologic oncology group study
Authors: Osama Rahma, Ed Achtar, Malgorzata Czystowska, Marta E. Szajnik, Eva Wieckowski, Sarah Bernstein, Vincent E. Herrin, Seth M. Steinberg, Maria Merino, William Gooding, Carmen Visus, Albert B. DeLeo, Jay A. Berzofsky, Theresa L. Whiteside, Judith K. Wolf, Jeffrey G. Bell, Samir N. Khleif
Journal: Cancer Research (2010)

Abstract Purpose: Peptide antigens have been administered by different approaches in cancer vaccine therapy, including direct injection or pulsed onto dendritic cells; however, the optimal delivery method is still debatable. In this study, we describe the immune response elicited by the wild-type (wt) p53 vaccine using two approaches. Experimental Design: Twenty-one HLA-A2.1 patients with stage III, IV, or recurrent ovarian cancer overexpressing the p53 protein with no evidence of disease were treated in two cohorts. Arm A received subcutaneous wt p53:264-272 peptide admixed with Montanide and GM-CSF. Arm B received wt p53:264-272 peptide-pulsed dendritic cells intravenously. Interleukin-2 (IL-2) was administered in both cohorts in alternative cycles. The immunologic response was assessed by ELISPOT and tetramer assays. Results: Nine of 13 patients (69%) in arm A and 5 of 6 patients (83%) in arm B had an immunologic response. The vaccine caused no serious systemic side effects. IL-2 administration resulted in grade 3 and 4 toxicities in both arms and directly induced expansion of T regulatory cells. The median overall survival was 40.8 and 29.6 months for arm A and B, respectively; the median progression-free survival was 4.2 and. 8.7 months, respectively. Conclusion: We demonstrated that using either vaccination approach could generate comparable specific immune responses against the wt p53 peptide with minimal toxicity. Accordingly, our findings support the utilization of the less demanding subcutaneous method. Furthermore, as IL-2 may add toxicity and induce T regulatory cells, which can suppress the immune response, therefore, it may not be needed in future trials. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2414.
When I use a word: Man hater
Authors: J. Aronson
Journal: BMJ (2003)

In his review of Steve Jones' book about the Y chromosome ( BMJ 2002;325:841), Fred Kavalier wonders what the male equivalent of a misogynist is. The Greeks had distinct words for man and mankind. A man (as opposed to a woman) was ![Graphic][1]</img> (aner; root andr-) and mankind (as opposed to the beasts) was ![Graphic][2]</img> (anthropos), from ![Graphic][3]</img> plus ![Graphic][4]</img> (ops), an eye. Of course, nothing is that simple. Aner also meant a man as opposed to a youth and a man as opposed to a god, although for the latter the words ![Graphic][5]</img> (brotos) or ![Graphic][6]</img> (thnetos, … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif [5]: /embed/inline-graphic-5.gif [6]: /embed/inline-graphic-6.gif
Strict glucose control in the critically ill
Authors: Peter Watkinson, Vicki S Barber, J Duncan Young
Journal: BMJ (2006)

May not be such a good thing for all critically ill patients 

I n 2001 Van den Berghe et al reported the results of a randomised controlled trial comparing the mortality of critically ill surgical patients receiving insulin infusions to achieve “tight glycaemic control” (target blood glucose 4.4-6.1 mmol/l) with that of patients receiving conventional treatment, where insulin was infused only if the blood glucose exceeded 11.9 mmol/l and was adjusted to maintain values of 10-11.1 mmol/l.1 The trial was stopped after 1548 patients had been enrolled because the mortality in the tight control group was 4.6% compared with 8% in the control group (32% corrected relative reduction; P = 0.04). Ever since, tight glycaemic control has been standard practice, but there are now good reasons to question it.

It always seemed surprising that a simple change in blood glucose management reduced mortality more than other far more costly and complex interventions tested through randomised trials in the critically ill. The only corroborating evidence came from studies of …
Comparison of Angiogenic Activities after Urethral Reconstruction Using Free Grafts in Rabbits
Authors: Stefanos Gardikis, Alexandra Giatromanolaki, Petros Ypsilantis, Sotiris Botaitis, Sabach Perente, Aikaterini Kambouri, Eleftheria Efstathiou, Spyros Antypas, Alexandros Polychronidis, Stavros Touloupidis, Efthimios Sivridis, Constantinos Simopoulos
Journal: European Urology (2004)
Distinct antiviral signaling pathways in primary human hepatocytes and their differential disruption by HCV NS3 protease
Authors: Loubna Jouan, Pierre Melançon, Ian-Gaël Rodrigue-Gervais, Valérie-Ann Raymond, Subajini Selliah, Geneviève Boucher, Marc Bilodeau, Nathalie Grandvaux, Daniel Lamarre
Journal: Journal of Hepatology (2009)
Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer
Authors: Tomer Cooks, Ioannis S. Pateras, Ohad Tarcic, Hilla Solomon, Aaron J. Schetter, Sylvia Wilder, Guillermina Lozano, Eli Pikarsky, Tim Forshew, Nitzan Rozenfeld, Noam Harpaz, Steven Itzkowitz, Curtis C. Harris, Varda Rotter, Vassilis G. Gorgoulis, Moshe Oren
Journal: Cancer Cell (2013)

The tumor suppressor p53 is frequently mutated in human cancer. Common mutant p53 (mutp53) isoforms can actively promote cancer through gain-of-function (GOF) mechanisms. We report that mutp53 prolongs TNF-α-induced NF-κB activation in cultured cells and intestinal organoid cultures. Remarkably, when exposed to dextran sulfate sodium, mice harboring a germline p53 mutation develop severe chronic inflammation and persistent tissue damage, and are highly prone to inflammation-associated colon cancer. This mutp53 GOF is manifested by rapid onset of flat dysplastic lesions that progress to invasive carcinoma with mutp53 accumulation and augmented NF-κB activation, faithfully recapitulating features frequently observed in human colitis-associated colorectal cancer (CAC). These findings might explain the early appearance of p53 mutations in human CAC.
Cutaneous<i>Cryptococcus</i>infection due to<i>C. albidus</i>associated with Sézary syndrome
Authors: S. Narayan, K. Batta, P. Colloby, C.Y. Tan
Journal: British Journal of Dermatology (2000)

Cryptococcus albidus is a non-neoformans species of the genus Cryptococcus and is a rare cause of disease. There have been only 13 previously reported cases of systemic disease in which this opportunistic yeast has been isolated from the lung, cerebrospinal fluid and blood. We report the first case of cutaneous Cryptococcus infection due to the species C. albidus, in a man with Sézary syndrome.
Hematology research in Paris
Authors: J. Bernard
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Airway obstruction in boilermakers exposed to fuel oil ash. A prospective investigation.
Authors: R Hauser, S Elreedy, J A Hoppin, D C Christiani
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

We prospectively investigated the lower airway response in boilermakers overhauling an oil-powered boiler. We studied 26 male boilermakers with a mean age (SD) of 43.3 (8.6) yr. Pre-exposure spirometry and methacholine challenge tests were performed before beginning the boiler overhaul; postexposure tests were performed after approximately 4 wk of work on the boiler. Exposure to particulates with an aerodynamic diameter of 10 microns and smaller (PM10) and respirable vanadium dust were estimated using daily work diaries and a personal sampling device for respirable particles. Using these estimates, we calculated average and peak exposure between pre- and postexposure tests for each subject. The average PM10 concentration ranged from 1.44 to 6.69 mg/m3, with a mean (SD) of 3.22 (1.42) mg/m3; the average vanadium concentration ranged from 2.2 to 31.3, with a mean (SD) of 12.2 (9.1) micrograms/m3. The mean postexposure fall in FEV1 was 140 +/- 160 ml (p < 0.01); 24 of 26 subjects had a drop in FEV1. For each subject, the adjusted change in FEV1 (delta FEV1.adj) was calculated by dividing the change in FEV1 by the average of the pre- and postexposure FEV1 values. The delta FEV1.adj was regressed, controlling age and current smoking status, on average and peak exposure to both PM10 and vanadium. There was a dose-response relationship between average and peak PM10 exposure and delta FEV1.adj: beta = -0.91% per mg/m3, p = 0.08 and beta = -1.03% per mg/m3, p = 0.03, respectively. However, there was no relationship between delta FEV1.adj and respirable vanadium dust concentration. Furthermore, there was no postexposure change in nonspecific airway responsiveness. In summary, we found a significant fall in FEV1 and a dose-response relationship between delta FEV1.adj and average and peak PM10 exposure.(ABSTRACT TRUNCATED AT 250 WORDS)
Catatonia isn't ready for a unified theory
Authors: Carrie E. Bearden, John R. Monterosso
Journal: Behavioral and Brain Sciences (2002)

Northoff's target article presents a unifying theory of the pathophysiology of catatonia, as compared to Parkinson's disease. We address two arguments in particular that do not appear justified by available evidence: (1) The physiological basis of catatonia is the breakdown of right hemisphere prefrontal-parietal cortical connectivity, and (2) Dysfunction in this system results in specific deficits in termination of action.
Oncogenic HRAS Activates Epithelial-to-Mesenchymal Transition and Confers Stemness to <i>p53</i>-Deficient Urothelial Cells to Drive Muscle Invasion of Basal Subtype Carcinomas
Authors: Feng He, Jonathan Melamed, Moon-shong Tang, Chuanshu Huang, Xue-Ru Wu
Journal: Cancer Research (2015)

Muscle-invasive urothelial carcinomas of the bladder (MIUCB) exhibit frequent receptor tyrosine kinase alterations, but the precise nature of their contributions to tumor pathophysiology is unclear. Using mutant HRAS (HRAS*) as an oncogenic prototype, we obtained evidence in transgenic mice that RTK/RAS pathway activation in urothelial cells causes hyperplasia that neither progresses to frank carcinoma nor regresses to normal urothelium through a period of one year. This persistent hyperplastic state appeared to result from an equilibrium between promitogenic factors and compensatory tumor barriers in the p19-MDM2-p53-p21 axis and a prolonged G2 arrest. Conditional inactivation of p53 in urothelial cells of transgenic mice expressing HRAS* resulted in carcinoma in situ and basal-subtype MIUCB with focal squamous differentiation resembling the human counterpart. The transcriptome of microdissected MIUCB was enriched in genes that drive epithelial-to-mesenchymal transition, the upregulation of which is associated with urothelial cells expressing multiple progenitor/stem cell markers. Taken together, our results provide evidence for RTK/RAS pathway activation and p53 deficiency as a combinatorial theranostic biomarker that may inform the progression and treatment of urothelial carcinoma.
Safety of Factor VIII
Authors: George F. Gjerset, James W. Mosley
Journal: Annals of Internal Medicine (1991)

Letters15 January 1991Safety of Factor VIIIGeorge F. Gjerset, MD, James W. Mosley, MDGeorge F. Gjerset, MDSearch for more papers by this author, James W. Mosley, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-2-171_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Mannucci and colleagues (1) reported the results of a hepatitis virus safety evaluation of 32 lots of factor VIII concentrate that were heat pasteurized in the liquid state. They tested serially collected serum samples obtained from 29 previously untreated hemophiliacs for antibody to hepatitis C virus (anti-HCV) and found no seroconversions. Similarly, they found no hepatitis B virus (HBV) infections among 15 HBV-seronegative subjects. Two aspects of their article warrant comment.The safety of plasma products, including intravenous immunoglobulin preparations (2), should not be assumed by the physician who encounters a case in which there was exposure...References1. Mannucci P, Schimpf K, and Brettler D. Low risk for hepatitis C in hemophiliacs given a high-purity, pasteurized factor VIII concentrate. Ann Intern Med. 1990;113:27-32. LinkGoogle Scholar2. Williams P and Yap P. Transmission of non-A, non-B hepatitis by pH4-treated immunoglobulin [Letter]. Vox Sang. 1990;58:309-10. CrossrefMedlineGoogle Scholar3. Brackmann H and Egli H. Acute hepatitis B infection after treatment with heat-inactivated factor VIII concentrate [Letter]. Lancet. 1988;2:967. CrossrefMedlineGoogle Scholar4. Dietrich S, Mosley J, and Lusher J. Transmission of human immunodeficiency virus type 1 by dry-heated clotting factor concentrates. Vox Sang. 1990;59:129-35. CrossrefMedlineGoogle Scholar5. Gjerset G. Impact of allotypic proteins in the treatment of HIV-1 infected hemophiliacs. Blood. 1989;74(Suppl):101A. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: George F. Gjerset, MD; James W. Mosley, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1991Volume 114, Issue 2Page: 171-171KeywordsBlood plasmaHepatitis B virusHepatitis C virusHepatitis virusesInfectious hepatitisIntravenous immunoglobulinSafety ePublished: 1 December 2008 Issue Published: 15 January 1991 PDF downloadLoading ...
Endothelial nucleotide catabolism and adenosine production
Authors: R. T Smolenski, Z. Kochan, R. McDouall, C. Page, A.-M. L Seymour, M. H Yacoub
Journal: Cardiovascular Research (1994)

Journal Article Endothelial nucleotide catabolism and adenosine production Get access Ryszard T Smolenski, Ryszard T Smolenski Magnetic Resonance Spectroscopy Group, Department of Cardiothoracic Surgery, National Heart and Lung Institute at Harefield Hospital, Harefield, Middlesex UB9 6JH, United Kingdom: R McDouall, C Page, A-M L Seymour, M H Yacoub; Department of Biochemistry, University Medical School of Gdansk, Poland: R T Smolenski, Z Kochan. Correspondence to Dr Seymour. Search for other works by this author on: Oxford Academic PubMed Google Scholar Zdzislaw Kochan, Zdzislaw Kochan Magnetic Resonance Spectroscopy Group, Department of Cardiothoracic Surgery, National Heart and Lung Institute at Harefield Hospital, Harefield, Middlesex UB9 6JH, United Kingdom: R McDouall, C Page, A-M L Seymour, M H Yacoub; Department of Biochemistry, University Medical School of Gdansk, Poland: R T Smolenski, Z Kochan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Rhoda McDouall, Rhoda McDouall Magnetic Resonance Spectroscopy Group, Department of Cardiothoracic Surgery, National Heart and Lung Institute at Harefield Hospital, Harefield, Middlesex UB9 6JH, United Kingdom: R McDouall, C Page, A-M L Seymour, M H Yacoub; Department of Biochemistry, University Medical School of Gdansk, Poland: R T Smolenski, Z Kochan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Chris Page, Chris Page Magnetic Resonance Spectroscopy Group, Department of Cardiothoracic Surgery, National Heart and Lung Institute at Harefield Hospital, Harefield, Middlesex UB9 6JH, United Kingdom: R McDouall, C Page, A-M L Seymour, M H Yacoub; Department of Biochemistry, University Medical School of Gdansk, Poland: R T Smolenski, Z Kochan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Anne-Marie L Seymour, Anne-Marie L Seymour Magnetic Resonance Spectroscopy Group, Department of Cardiothoracic Surgery, National Heart and Lung Institute at Harefield Hospital, Harefield, Middlesex UB9 6JH, United Kingdom: R McDouall, C Page, A-M L Seymour, M H Yacoub; Department of Biochemistry, University Medical School of Gdansk, Poland: R T Smolenski, Z Kochan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Magdi H Yacoub Magdi H Yacoub Magnetic Resonance Spectroscopy Group, Department of Cardiothoracic Surgery, National Heart and Lung Institute at Harefield Hospital, Harefield, Middlesex UB9 6JH, United Kingdom: R McDouall, C Page, A-M L Seymour, M H Yacoub; Department of Biochemistry, University Medical School of Gdansk, Poland: R T Smolenski, Z Kochan. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 1, January 1994, Pages 100–104, https://doi.org/10.1093/cvr/28.1.100 Published: 01 January 1994 Article history Received: 23 April 1993 Accepted: 27 September 1993 Published: 01 January 1994
LRP6 Enhances Glucose Metabolism by Promoting TCF7L2-Dependent Insulin Receptor Expression and IGF Receptor Stabilization in Humans
Authors: Rajvir Singh, Renata Belfort De Aguiar, Sarita Naik, Sheida Mani, Kamal Ostadsharif, Detlef Wencker, Masoud Sotoudeh, Reza Malekzadeh, Robert S. Sherwin, Arya Mani
Journal: Cell Metabolism (2013)
Pulmonary oedema after transfusion with fresh frozen plasma.
Authors: P J Wyld, B E Woodcock
Journal: BMJ (1981)

phosphodiesterase-inhibiting properties,' and more recently functional SRS-A antagonism.2The clinical relevance of these properties is the subject of further investigation.Ketotifen was shown early in its development to inhibit antigen-induced bronchospasm in man when given orally.3This encouraged further clinical development, leading to other controlled trials, now reported4-9 (also by Carrasco et al at 11th International Congress of Allergology, Jerusalem, 1979), as well as the one cited'' in the review.The majority of trials, particularly the long-term studies, demonstrate efficacy for ketotifen in com- parison with placebo or other agents.4-10
Preoperative Chemotherapy (Cisplatin and Fluorouracil) and Radiation Therapy in Stage III Non-Small-Cell Lung Cancer: A Phase II Study of the Lung Cancer Study Group
Authors: P. L. Weiden, S. Piantadosi
Journal: JNCI Journal of the National Cancer Institute (1991)

The Lung Cancer Study Group conducted a phase II pilot study of concurrent chemotherapy and radiation therapy (chemoradiotherapy) before surgery in 85 eligible patients with non-small-cell cancer limited to the chest but in whom attempted resection would have been likely to leave residual disease (advanced stage IIIA and minimal stage IIIB disease). Cisplatin, 75 mg/m 2 , was given on days 1 and 29; fluorouracil, 1 g/ 2 per 24 hours, was administered as a continuous infusion on days 1 through 4 and on days 29 through 32; and thoracic radiation, 30 Gy in 15 fractions, was administered on days 1 through 19. Two patients achieved a complete response and 46 patients had a partial response for an overall response rate of 56%. Toxicity from chemoradiotherapy was moderate but acceptable. Eight weeks after therapy was initiated, 54 patients underwent thoracotomy and tumor resection was attempted: 29 (34%) had complete resection and 15 (18%) had incomplete resection. Although surgical dissection was generally more difficult than in patients not pretreated with chemoradiotherapy, there was no apparent increase in postoperative complications. In 8 patients (9%), no viable tumor was detected pathologically in the resection specimen. Of the 18 patients whose tumors were completely resected and had disease recurrence, none had recurrence only in the chest, 12 (67%) had recurrence only in distant sites, and 3 developed second primary tumors. Median survival of all patients was 13 months. The overall results do not indicate a major benefit from this preoperative chemoradiotherapy regimen in patients with advanced but potentially resectable non-small-cell lung cancer. These results suggest a need to define better the relative roles of preoperative radiotherapy and chemotherapy. [J Natl Cancer Inst 83: 266–272, 1991]