tbuckley/cabot-search huggingface dataset:
Bell ringers' bruises and broken bones: capers and crises in campanology.
Authors: A C Lamont, N J London
Journal: BMJ (1990)

OBJECTIVE--To determine the incidence, aeriology, and outcome of injuries due to bell ringing. DESIGN--Retrospective review of the last six years9 issues of Ringing World, advertisement in Ringing World, and a postal questionnaire sent to 20 active ringing towers. SUBJECTS--Regular bell ringers. RESULTS--Seventy nine injuries were identified both from review and by advertisement in Ringing World. The incidence of injury among 221 ringers identified by postal questionnaire was 1.8% a year. CONCLUSION--Although sonerous, bell ringing can be dangerous and occasionally even fatal. Doctors should be aware of the dangers to which campanologists expose themselves.
Chronic Physical Effects and Health Care Utilization in Long-Term Ovarian Germ Cell Tumor Survivors: A Gynecologic Oncology Group Study
Authors: Daniela Matei, Anna M. Miller, Patrick Monahan, David Gershenson, Qianqian Zhao, David Cella, Victoria L. Champion, Stephen D. Williams
Journal: Journal of Clinical Oncology (2009)

This study compares late effects of treatment on physical well-being and utilization of health care resources between ovarian germ cell tumor (OGCT) survivors and age/race/education-matched controls.
FDA Trying to Make Case for Tobacco Regulation
Authors: Marsha F. Goldsmith
Journal: JAMA (1994)

EVEN AS relaxing the enforcement of laws against the makers, sellers, buyers, and users of substances known to be addictive has gained a tentative hold on the thinking of some government officials, others are working hard to discover whether the free ride long enjoyed by what some say is the most addictive of all so-called recreational substances ought to be reined in. In what appears to be an all-out push to make up for some 20 years of lost time, the Food and Drug Administration (FDA) has assigned "a very high priority," according to its chief, to learning enough about nicotine to decide whether it should be regulated through legislation as a drug. David Kessler, MD, the agency's director, says there has been a shift in thinking since the 1970s, when the FDA last considered what, if anything, to do about nicotine. At that time, even though using tobacco was
Laser therapy of lichenoid red tattoo reaction
Authors: C. Hindson, I. Foulds, J. Cotterill
Journal: British Journal of Dermatology (1995)

Journal Article Laser therapy of lichenoid red tattoo reaction Get access C. Hindson, C. Hindson Lasercare Clinics Ltd., The Skin Hospital 35, George Road, Birmingham B15 1PR, U.K. Search for other works by this author on: Oxford Academic Google Scholar I. Foulds, I. Foulds Lasercare Clinics Ltd., The Skin Hospital 35, George Road, Birmingham B15 1PR, U.K. Search for other works by this author on: Oxford Academic Google Scholar J. Cotterill J. Cotterill Lasercare Clinics Ltd., The Skin Hospital 35, George Road, Birmingham B15 1PR, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 133, Issue 4, 1 October 1995, Pages 665–666, https://doi.org/10.1111/j.1365-2133.1995.tb02733.x Published: 01 October 1995
998-121 Effect of Hormone Replacement Therapy on Fibrinogen Level in Postmenopausal Women in the Framingham Offspring Study
Authors: Murray A. Mittleman, Otavio C.E. Gebara, Patrice Sutherland, Travis Matheney, Izabela Lipinska, Francine K. Welty, Daniel Levy, Peter W.F. Wilson, James E. Muller, Geoffrey H. Tofler
Journal: Journal of the American College of Cardiology (1995)
Abstract 3727: Targeting autotaxin to reduce chemotherapy resistance in ovarian cancer
Authors: Ling Zhai, Ali Zamani, Ximeng Liu, Yimin Wang, Yulia Maxuitenko, Ronald Alvarez, Jacob Estes, Rongbao Li, Zhican Qu
Journal: Cancer Research (2012)

Abstract Development of resistance to chemotherapy presents the biggest challenge in the treatment of ovarian cancer. Autotaxin (ATX) is a secreted enzyme that catalyzes lysophosphatidic acid (LPA) production and is responsible for the up-regulation of LPA in ovarian cancer. The ATX-LPA axis has been identified to be one of the mechanisms of chemotherapy resistance in ovarian cancer. Thus, inhibition of autotaxin may be a potential strategy to increase the chemotherapy efficacy in this disease context. At Southern Research, we previously identified a known anti-parasitic small molecule, Bithionol as a potent antiangiogenic agent, which inhibits endothelial cell proliferation, migration and tubular morphogenesis in vitro and directly inhibits autotaxin enzyme activity. Our recent results have shown that Bithionol not only directly inhibits the enzyme activity; it also reduces autotaxin secretion from human endothelial and ovarian cancer cells. Recently, using a human ovarian cancer xenograft mouse model, Biothionol was shown to have in vivo anti-tumor activity as a single drug treatment. In addition, in combination therapy studies in mice, Bithionol significantly increased the efficacy of Paclitaxel and Cisplatin against ovarian tumor growth. These results suggest that Bithionol may provide a promising approach for reducing chemotherapy associated resistance in ovarian cancer. Additional preclinical studies are in progress to assess the potential clinical utility of Bithionol in combination with current ovarian cancer therapy. (This work is supported by a pilot grant from Norma Livingston Foundation and SRI SIP fund). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3727. doi:1538-7445.AM2012-3727
Functional Polymorphism in the Regulatory Region of Gelatinase B Gene in Relation to Severity of Coronary Atherosclerosis
Authors: Baiping Zhang, Shu Ye, Stefan-Martin Herrmann, Per Eriksson, Moniek de Maat, Alun Evans, Dominique Arveiler, Gérald Luc, François Cambien, Anders Hamsten, Hugh Watkins, Adriano M. Henney
Journal: Circulation (1999)

Background —Gelatinase B , a matrix metalloproteinase that has proteolytic activity against connective tissue proteins, has been suggested to be important in the connective tissue remodeling processes associated with atherogenesis and plaque rupture. This study tested the hypothesis that sequence variation in the promoter region of the gelatinase B gene influences its expression, predisposing individuals carrying certain genetic variants to more severe atherosclerosis. Methods and Results —Single-strand conformation polymorphism analysis was carried out to search the promoter region of the gene encoding gelatinase B for naturally occurring genetic variation. As a result, an unreported common polymorphism was detected, which arose from a cytosine (C) to thymidine (T) transition at position −1562 relative to the start of transcription. Transient transfection experiments and DNA-protein interaction assays indicated that the T allele had a higher promoter activity than the C allele, which appeared to be due to preferential binding of a putative transcription repressor protein to the C allelic promoter. A sample of 584 male patients with myocardial infarction and 645 age-matched male healthy control subjects were genotyped. The allele frequencies were not significantly different between the cases and control subjects. However, in 374 patients with available angiographic data, 26% of those carrying 1 or 2 copies of the T allele had &gt;50% stenosis in 3 coronary arteries, whereas only 15% of C/C homozygotes had triple-vessel disease. Conclusions —These data suggest that this functional genetic variation influences gelatinase B gene promoter activity in an allele-specific manner and has an effect on atherosclerotic phenotype.
THE EFFECT OF FEMALE GENDER ON CARDIAC ARRHYTHMIAS IN ACUTE CORONARY SYNDROMES: INSIGHTS FROM THE SECOND GULF REGISTRY OF ACUTE CORONARY EVENTS
Authors: Amar Salam, Khalid AlHabib, Kadhim Sulaiman, Alawi Alsheikh-Ali, Wael Almahmeed, Haitham Amin, Jawad Al-Lawati, Ahmed Al-Motarreb, Rajvir Singh, Jassim Al Suwaidi
Journal: Journal of the American College of Cardiology (2014)
Embolic Catheter Removed From Pulmonary Artery
Authors: Mahmood Mirhoseini
Journal: JAMA (1967)

<h3>To the Editor:—</h3> The first reported operative removal of an intravenous polyethylene catheter from the pulmonary artery has occasioned the following clinical report. <h3>Report of a Case:—</h3> A 44-year-old white man suffered a sudden onset of chest pain on the left side, associated with dyspnea, particularly with deep respirations. The patient was admitted to St. Luke's Hospital with a tentative diagnosis of pulmonary embolism. A chest roentgenogram revealed a radiopaque foreign body in the pulmonary artery. Lateral x-ray films showed the major portion of the foreign body to be in the artery of the lower lobe and a small portion in the anterior segmental branch of the upper lobe (Fig 1). Ten months earlier the patient had undergone an operative procedure for prostate and bladder difficulty. At that time medication was given by an indwelling intravenous system. The x-ray film at that time showed a normal-appearing chest. Approximately 1 1/2
A variant in the CD209 promoter is associated with severity of dengue disease
Authors: Anavaj Sakuntabhai, Chairat Turbpaiboon, Isabelle Casadémont, Ampaiwan Chuansumrit, Tassanee Lowhnoo, Anna Kajaste-Rudnitski, Sita Mint Kalayanarooj, Kanchana Tangnararatchakit, Nattaya Tangthawornchaikul, Sirijit Vasanawathana, Wathanee Chaiyaratana, Pa-thai Yenchitsomanus, Prapat Suriyaphol, Panisadee Avirutnan, Kulkanya Chokephaibulkit, Fumihiko Matsuda, Sutee Yoksan, Yves Jacob, G Mark Lathrop, Prida Malasit, Philippe Desprès, Cécile Julier
Journal: Nature Genetics (2005)
Effects of Second Messengers on the Permeability and Morphology of Eel Rete Capillaries
Authors: Eugenio A. Rasio, Moı̈se Bendayan, Carl A. Goresky
Journal: Circulation Research (1995)

Abstract The effects of second-messenger concentration changes on capillary diffusion capacity (permeability–surface area product [PS]) to cellular and paracellular tracers and on capillary ultrastructure were studied during countercurrent perfusion of the rete of the eel swim bladder. Cyclic nucleotide effects were investigated with isoproterenol, forskolin, and dibutyryl cAMP. Isoproterenol (5×10 −6 mol/L) did not modify water and solute permeability or capillary structure. Forskolin (10 −4 mol/L) immediately raised the concentrations of cAMP in the rete and produced interstitial edema but did not change permeability. The addition of dibutyryl cAMP (10 −6 mol/L) to the perfusate had rapid effects: it reduced the PS of [ 3 H]water and oxygen and increased the PS of [ 125 I]albumin, [ 14 C]sucrose, and 22 Na. No structural changes were observed. Phosphoinositide effects were studied with 1,2-dioctanoyl- sn -glycerol (DG) and phorbol 12-myristate 13-acetate (PMA). DG (10 −5 mol/L) had no effect on the permeability of the rete to water and solutes, while inducing cell membrane vacuolization. PMA (10 −5 mol/L) progressively reduced the PS of [ 3 H]water. In contrast, PS values of [ 125 I]albumin, [ 14 C]sucrose, and 22 Na rose gradually. Membrane vacuoles bulging into the lumen and in the cytoplasm were a common feature. The Ca 2+ effect was investigated with the Ca 2+ ionophore A23187. At 5×10 −6 mol/L, unsteady permeability changes and extensive cytolysis were observed. At 5×10 −7 mol/L, the PS of [ 125 I]albumin, [ 14 C]sucrose, and 22 Na rapidly increased. The PS values for water were not modified. No structural changes were identified. It is concluded that increments of second-messenger concentrations in the rete induce characteristic selective effects on the paracellular and transcellular pathways of transport and create significant but nonselective alterations of capillary structure.
Abortion doctor suffers second attack in six years
Authors: D. Spurgeon
Journal: BMJ (2000)

A Vancouver gynaecologist, Dr Garson Romalis, who performs abortions and who was shot six years ago as he ate breakfast in his home (BMJ 1994; 309:1322), has been stabbed by a young man in the lobby of his office at a medical clinic.

Since this latest attack, Dr Ellen Wiebe, another Vancouver gynaecologist who had during the previous week announced she had begun clinical trials with the abortion pill mifepristone (RU-486), …
The effect of -adrenoceptor and Ca2+ antagonist drugs on the hypoxia-induced increase in resting tension
Authors: W. G. NAYLER, C. E. YEPEZ, P. A. POOLE-WILSON
Journal: Cardiovascular Research (1978)

Using isolated, Langendorff-perfused, electrically-paced guinea-pig hearts, we have investigated the rise in resting tension that occurs when mammalian heart muscle becomes hypoxic. Substrate-depletion, tachycardia, hyperthyroidism, and inotropic interventions (ouabain, isoprenaline, and beta-receptor antagonists at concentrations which increase inotropic state) enhanced the rate of development of this increase in resting tension. 3.86 mumol.litre-1 propranolol, 0.22 to 2.20 mumol.litre-1 verapamil or removing Ca2+ from the extracellular phase at the start of the hypoxic episode prevented (or delayed) the rise in resting tension. Adding these same agents or removing Ca2+ from the extracellular phase after the hypoxia-induced rise in resting tension had started to develop failed to prevent its progression. These results provide some support for an hypothesis that the hypoxia-induced increase in resting tension is independent of an enhanced Ca2+ influx.
Note on the Antivenomous and Antitoxic Qualities of the Bile of Serpents and of Other Animals
Authors: None Fraser
Journal: BMJ (1897)

should not surpass the wit of man to find a remedy.I am quitc aware of the difficulties that meet the individual prac- titioner.I have been too long a general practitioner, before specialising, to have missed my share of those experiences, and perhaps it may raise a smile if I say, from that point of view, " that the gossips being uneasy," in the language of Smellie, is one of the real difficulties in the way of reform, if by " gossips " we mean those interested in the patient, who may have some sort of right to ask questions, or claim the privilege of offering well-meant but ignorant suggestions con-
Mitochondrial calcium regulates rat liver regeneration through the modulation of apoptosis
Authors: Mateus T. Guerra, Emerson A. Fonseca, Flavia M. Melo, Viviane A. Andrade, Carla J. Aguiar, Lídia M. Andrade, Ana Cristina N. Pinheiro, Marisa C. F. Casteluber, Rodrigo R. Resende, Mauro C. X. Pinto, Simone O. A. Fernandes, Valbert N. Cardoso, Elaine M. Souza-Fagundes, Gustavo B. Menezes, Ana M. de Paula, Michael H. Nathanson, Maria de Fátima Leite
Journal: Hepatology (2011)

Subcellular Ca(2+) signals control a variety of responses in the liver. For example, mitochondrial Ca(2+) (Ca(mit)(2+)) regulates apoptosis, whereas Ca(2+) in the nucleus regulates cell proliferation. Because apoptosis and cell growth can be related, we investigated whether Ca(mit)(2+) also affects liver regeneration. The Ca(2+)-buffering protein parvalbumin, which was targeted to the mitochondrial matrix and fused to green fluorescent protein, was expressed in the SKHep1 liver cell line; the vector was called parvalbumin-mitochondrial targeting sequence-green fluorescent protein (PV-MITO-GFP). This construct properly localized to and effectively buffered Ca(2+) signals in the mitochondrial matrix. Additionally, the expression of PV-MITO-GFP reduced apoptosis induced by both intrinsic and extrinsic pathways. The reduction in cell death correlated with the increased expression of antiapoptotic genes [B cell lymphoma 2 (bcl-2), myeloid cell leukemia 1, and B cell lymphoma extra large] and with the decreased expression of proapoptotic genes [p53, B cell lymphoma 2-associated X protein (bax), apoptotic peptidase activating factor 1, and caspase-6]. PV-MITO-GFP was also expressed in hepatocytes in vivo with an adenoviral delivery system. Ca(mit)(2+) buffering in hepatocytes accelerated liver regeneration after partial hepatectomy, and this effect was associated with the increased expression of bcl-2 and the decreased expression of bax.Together, these results reveal an essential role for Ca(mit)(2+) in hepatocyte proliferation and liver regeneration, which may be mediated by the regulation of apoptosis.
Obscure Intussusception Diagnosed by Ultrasonography
Authors: Hugo Uhland
Journal: JAMA (1978)

ILEOCOLIC intussusception, though common in children, is extremely rare in adults. To our knowledge, only 160 cases have been recorded in the literature since 1952.<sup>1</sup>A case of ileocolic intussusception in an elderly woman was diagnosed by ultrasonography. <h3>Report of a Case</h3> A 90-year-old woman entered the Emergency Department with a four-day history of diffuse midupper abdominal pain. At the time of admission, she had no nausea or vomiting. She had four watery, diarrheal stools, with no evidence of blood during the preceding 12 hours. Examination of the abdomen showed a 10- to 12-cm, tubular, firm, minimally tender mass located in the right side of the upper abdomen. Bowel sounds were hypoactive. Rectal examination was normal, and the stool was weakly positive for blood by guaiac determination. Results of a complete blood cell count and chemistry screen were normal. Plain films of the abdomen were normal. A barium examination
The Support of Continuing Medical Education by Pharmaceutical Companies
Authors: Norman M Kaplan
Journal: New England Journal of Medicine (1979)

This communication is being started as I await a flight to New Orleans, where I am to give Medical Grand Rounds at the LSU Medical School later today. The expenses for my trip and an honorarium of $500 are being provided by the USV Pharmaceutical Company. These arrangements were made by the chairman of the department who wished to invite me. My talk, "Alpha- and Beta-Blockers in the Treatment of Hypertension," will make only brief mention of diuretics and no reference to the diuretic marketed by USV, the only antihypertensive agent sold by that company.These details provide a background . . .
Role of modern radiological investigations in obstructive uropathy.
Authors: P H O'Reilly
Journal: BMJ (1982)

Obstructive uropathy in its various forms accounts for much of the work load in urological units and general hospitals. Until recently, laboratory tests and excretion urography were the only procedures available for its assessment. The past few years have seen the development and refinement of ultrasound, examination by computer tomography, nuclear medicine, antegrade pyelography, and perfusion pressure flow studies. This paper examines the particular qualities of these modern procedures and their role in the clinical assessment of the obstructed urinary tract.
Effects of Coumarin Compounds on the Fetus
Authors: Sidney J. Fillmore, Ellen Mc Devitt
Journal: Annals of Internal Medicine (1970)

Thirty-six pregnancies during which coumarin compounds were administered were reviewed to determine the risks these drugs pose to the fetus. The stage of pregnancy when treatment was begun, previous obstetric history, duration of treatment, drugs used, adequacy of control, and outcome of the pregnancy were considered. Thirty-two women delivered normal infants. Four pregnancies resulted in stillbirths. Three of these women had had previous obstetric complications, and the fourth had documented hypoprothrombinemia for 4 days before fetal movement ceased. The stage of pregnancy when therapy started and the duration of treatment were not important determinants of survival. Although occasional hypoprothrombinemia was not usually lethal, two of the four fetal deaths occurred in cases in which the prothrombin time was more than three times the control time at least on two occasions. All women with a normal obstetric history and adequate control of the prothrombin time delivered normal infants.
STUDIES ON NEOPLASMS WITH THE AID OF RADIOACTIVE PHOSPHORUS. II. THE PHOSPHORUS METABOLISM OF THE NUCLEOPROTEIN, PHOSPHOLIPID AND ACID SOLUBLE FRACTIONS OF NORMAL AND LEUKEMIC MICE
Authors: L. W. Tuttle, L. A. Erf, J. H. Lawrence
Journal: Journal of Clinical Investigation (1941)

Previous studies (1, 2) have shown that the phosphorus metabolism of mouse tissues is mark-
Tuberculous Colonic Strictures: Impact of Dilation on Diagnosis
Authors: S. P. Misra, V. Misra, M. Dwivedi, J. S. Arora, B. K. Kunwar
Journal: Endoscopy (2004)

Background and Study Aim: Colonic strictures are commonly encountered in patients with colonic tuberculosis. If the colonoscope cannot be negotiated past the stricture the procedure is abandoned, the colonic mucosa proximal to the stricture cannot be inspected, and therefore lesions in these locations may be missed. Patients and Methods: 130 patients with colonic tuberculosis were studied. Of these 22 (17 %) had impassable colonic strictures. These strictures were dilated, the colonic mucosa proximal to the strictures was then inspected, and biopsies were obtained from lesions of suspicious appearance. Results: All strictures could be dilated. No abnormality was found in 11 patients. In the other 11 patients one or more additional findings were noted on colonoscopy after dilation. A second stricture was found in three patients. Nodularity and/or ulceration was observed in the colon proximal to the site of the primary stricture in ten patients. Dilation of the strictures and histological examination of the biopsy from target lesions of the proximal colon contributed to making the definitive diagnosis in five patients. The diagnosis was not altered in the remaining six patients. Conclusion: Dilation of colonic strictures facilitates inspection of the colonic mucosa proximal to the strictures, enabling biopsy of target lesions. This approach offers important diagnostic clues and confirmation of the diagnosis in several patients in whom lesions might be missed if strictures are not dilated.
DIAGNO II: Further Developments in a Computer Program for Psychiatric Diagnosis
Authors: ROBERT L. SPITZER, JEAN ENDICOTT
Journal: American Journal of Psychiatry (1969)

DIAGNO II, a computer program for psychiatric diagnosis, is based on a logical decision tree model similar to the differential diagnostic process used in clinical medicine. In the validity study reported here, the program yielded diagnoses for 100 patients which agreed with diagnoses supplied by clinicians as well as did the diagnoses supplied by different clinicians on the same cases.
Prophylactic zanamivir: effective prevention of influenza A and B in household contacts of laboratory proven influenza
Authors: D D Creer
Journal: Thorax (2003)

Monto AS, Pichichero ME, Blanckenberg SJ, et al . Zanamivir prophylaxis: an effective strategy for the prevention of influenza types A and B within households. J Infect Dis2002;186:1582–8 [OpenUrl][1][Abstract/FREE Full Text][2] This double blind, multicentre study performed over a single winter season recruited 1291 household contacts (>5 years old) of 485 patients presenting with an influenza-like illness (occurring when influenza was known to be circulating locally). Household contacts were randomised … [1]: {openurl}?query=rft.jtitle%253DJ%2BInfect%2BDis%26rft_id%253Dinfo%253Adoi%252F10.1086%252F345722%26rft_id%253Dinfo%253Apmid%252F12447733%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=jinfdis&resid=186/11/1582&atom=%2Fthoraxjnl%2F58%2F2%2F121.atom