tbuckley/cabot-search huggingface dataset:
Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia
Authors: Guillermo Garcia-Manero, Sarit Assouline, Jorge Cortes, Zeev Estrov, Hagop Kantarjian, Hui Yang, Willie M. Newsome, Wilson H. Miller, Caroline Rousseau, Ann Kalita, Claire Bonfils, Marja Dubay, Tracy-Ann Patterson, Zuomei Li, Jeffrey M. Besterman, Gregory Reid, Eric Laille, Robert E. Martell, Mark Minden
Journal: Blood (2008)
Patient Preference for Radiotherapy Fractionation Schedule in the Palliation of Painful Bone Metastases
Authors: Thomas P. Shakespeare, Jiade J. Lu, Michael F. Back, Shen Liang, Rahul K. Mukherjee, Christopher J. Wynne
Journal: Journal of Clinical Oncology (2003)

Purpose: The radiotherapeutic management of painful bone metastases is controversial, with several institutional and national guidelines advocating use of single-fraction radiotherapy. We aimed to determine patient choice of fractionation schedule after involvement in the decision-making process by use of a decision board. Patients and Methods: Advantages and disadvantages of two fractionation schedules (24 Gy in six fractions v 8 Gy in one fraction) used in the randomized Dutch Bone Metastasis Study were discussed with patients using a decision board. Patients were asked to choose a fractionation schedule, to give reasons for their choice, and to indicate level of satisfaction with being involved in decision making. Results: Sixty-two patients were entered. Eighty-five percent (95% confidence interval, 74% to 93%) chose 24 Gy in six fractions over 8 Gy in one fraction (P &lt; .0005). Variables including age, sex, performance status, tumor type, pain score, and paying class were not significantly related to patient choice. Multiple fractionation was chosen for lower re-treatment rates (92%) and fewer fractures (32%). Single-fraction treatment was chosen for cost (11%) and convenience (89%). Eighty-four percent of patients expressed positive opinions about being involved in the decision-making process. Conclusion: Decision board instruments are feasible and acceptable in an Asian population. The vast majority of patients preferred 24 Gy fractionated radiotherapy compared with a single fraction of 8 Gy. These results indicate the need for further research in this important area and serve to remind both clinicians and national or institutional policy makers of the importance of individual patient preference in treatment decision making.
Half of acute trusts in London are not viable, say MPs
Authors: N. Hawkes
Journal: BMJ (2011)

The financial and clinical viability of many NHS hospitals has deteriorated, making it “extremely difficult” for them all to become foundation trusts by April 2014, the House of Commons Public Accounts Committee has concluded.

London presents especially acute problems ( BMJ 2011;343:d8130, 13 Dec, doi:10.1136/bmj.d8130). “We are particularly alarmed that the healthcare system in London has been allowed to deteriorate despite its problems having been known about for many years,” the committee’s report says. “At least half of the acute trusts in London are not viable in their current form.”

To become foundation trusts, hospitals need to have strong governance, long term financial viability, and a framework to deliver high quality services. Between 2004 and September 2011 139 acute care …
Friendly Case of Poisoning: What Dunnit?
Authors: Frederick A. J. Kingery
Journal: JAMA (1964)

A 54-YEAR-OLD previously healthy itinerant farm laborer was admitted to the hospital with the following story: Three weeks ago he had consumed several bottles of wine, the gift of a "friend." Forty-eight hours later, when he commenced to experience midanterior chest pain, stomachache, generalized weakness, and muscle pain, he recalled that the wine had been opened prior to the giving, suggesting to the patient that his friend's gesture was a sinister one. The above complaints persisted until his admission three weeks later. Initial physical examination, including a careful neurological examination, was normal. Urine values for lead and arsenic were both normal. Prothrombin time was not prolonged. The patient was observed for a week with no clue regarding source or type of poison until suddenly, 28 days after ingestion of the wine, he ran his hand over his scalp and removed large quantities of hair (Figure). Within the next week virtually
Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin
Authors: Charles C. Chu, Rosa Catera, Lu Zhang, Sebastien Didier, Briana M. Agagnina, Rajendra N. Damle, Matthew S. Kaufman, Jonathan E. Kolitz, Steven L. Allen, Kanti R. Rai, Nicholas Chiorazzi
Journal: Blood (2010)
Medical and Social Screening of Patients aged 70 to 72 by an Urban General Practice Health Team
Authors: G. Currie, R. M. Macneill, J. G. Walker, E. Barnie, E. W. Mudie
Journal: BMJ (1974)

A medico-social survey of 259 elderly patients aged 70-72 was carried out by three doctors, a health visitor and a nurse in an urban general practice. Seven hundred and ninety diseases or disabilities were identified-an average of 3.2 per patient-of which 20.5% were unknown to the doctors. Using a simple check list for symptom inquiry, the health visitor or nurse missed very little of the physical or psychological disease. In some respects their symptom inquiry was more revealing than that of the doctors but they had difficulty in eliciting evidence of malnutrition, masked depression, and incipient dementia. Initial health screening of the elderly for unreported disease in general practice can easily be done by a health visitor with training in geriatric problems and the recognition of psychiatric illness.Initial health screening can also be done by a nurse with community-nursing experience but she will require additional training in the techniques of social assessment. The doctor must examine those patients found to be suffering from alerting symptoms. A general practice of three or four doctors requires one health visitor for routine work and one additional health visitor or nurse for screening of the elderly. Unreported disease in the elderly indicates failure to make contact and failure to ask the right questions. Unknown disease may be due to inadequate records.
Samuel Rutherford Fee
Authors: Jennifer Wilton, Alastair Fee, Calum Fee
Journal: BMJ (2004)

Former general practitioner Tunstall, Stoke-on-Trent (b 1908; q Glasgow 1932; OBE, FRCGP), d 24 July 2004.​2004.




Figure 1




Samuel Rutherford Fee became an assistant at a practice in Basford, Stoke-on-Trent, in 1936, subsequently becoming a partner in Tunstall. With this came the post of medical officer of Westcliffe Hospital. He also became clinical assistant in medicine at the Haywood Hospital, Burslem. He supported the building of the North Staffordshire Medical Institute in 1963, becoming its first GP chairman in 1972. He was elected a fellow of the BMA in 1968. Failing sight made him retire at 80. Predeceased by his wife, he leaves three children and seven grandchildren.
THE EMIGRATION OF PNEUMOCOCCI TYPE III FROM THE BLOOD INTO THE THORACIC DUCT LYMPH OF RABBITS, AND THE SURVIVAL OF THESE ORGANISMS IN THE LYMPH FOLLOWING INTRAVENOUS INJECTION OF SPECIFIC ANTISERUM
Authors: Cecil K. Drinker, John F. Enders, Morris F. Shaffer, Octa C. Leigh
Journal: The Journal of Experimental Medicine (1935)

1. Rabbits injected intravenously with a large dose of a virulent Type III Pneumococcus develop a bacteremia, and within an hour organisms may be cultivated from the thoracic duct lymph. The rapidity with which entrance into the lymph occurs appears to be correlated with the size of the dose injected. 2. The organisms may become more numerous in the lymph than in the blood. 3. If homologous or heterologous antisera are injected, the blood may be sterilized, but though the organisms may be lessened in the lymph, sterilization at least within 4 hours is not secured, and in the intact animal living organisms must continue to enter the blood with the thoracic duct lymph. 4. In infected rabbits after intravenous injection of considerable quantities of antisera containing moderate amounts of agglutinin, no antibody appears in the thoracic duct lymph although the presence of horse serum may be detected. The injection of a very large quantity of antiserum containing a high titre of agglutinin is followed by the penetration of antibody into the lymph. This, however, has failed to sterilize the lymph or to permanently affect the rate of multiplication of the pneumococci.
Discussion on Proprietary Remedies.
Authors: Joseph P. Remington
Journal: JAMA (1904)

Philadelphia, Dec. 5, 1904. <h3>To the Editor:</h3> —On page 1680 ofThe Journalof the American Medical Association I am quoted as stating that eucain "is probably not worth anything." I trust that you will publish the statement that I had no intention whatever of singling out in the discussion eucain, and of stating that "it is probably not worth anything," for I have never believed this.
ABC of healthy travel. Preventing illness while abroad.
Authors: E Walker, G Williams
Journal: BMJ (1983)

WaterWith inmmunisations behind him, and with antimalarial and possibly antidiarrhoeal tablets in hand, the departing traveller may be tempted to Food think that no further health precautions are necessary.Few of these preliminary measures are fully effective, however, and unexpected diseases may occur.Many illnesses could be, prevented by simple precautions-rn Personal hygiene particular with water, food, and personal hygiene.Care over sunbathing and unfamiliar surroundings that lead to accidents have been mentioned already. Orinking waterAt present three-fifths of the world's population are estimnated to have inadequate supplies of drinking water, and one of the aims of the International Drinking Water Supply and Sanitation Decade is to provide good drinking water for all by 1989.Contmnton of drinking water with living organisms is a majo'r cause of illness among travellers.In Britain we drink water straight from the tap and rarely consider that water may be a source of disease.Most short-stay tourists are unlikely to face a shortage, but when this occurs the water may carry a higher proportion of impurities and disease-causing organisms because of concentration.Escherichia coli gastroenteritis, giardiasis, shigellosis, amoebic dysentery, hepatitis A, typhoid, and cholera may all be water-borne.When the source and cleanliness of a water'supply are in doubt the best means of sterilising drinking water is by boiling.Filtration and chlorination with tablets, either alone or together, are second best options because of the limitations of and difficulties in controlling'these methods by the casual user.Some cysts and organisms such as hepatitis A virus can be very resistant.Water used for (', ~~~~~~brushing gums and teeth, for washing foods, and for making ice may also f -7.. ~~be sources of infection.Babies who are breast-fed are unlikely to be '~~~';.~~~~infected until water is drunk and weaning begins, and the value of
MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16
Authors: Hang Yin, Alessandra Pasut, Vahab D. Soleimani, C. Florian Bentzinger, Ghadi Antoun, Stephanie Thorn, Patrick Seale, Pasan Fernando, Wilfred van IJcken, Frank Grosveld, Robert A. Dekemp, Robert Boushel, Mary-Ellen Harper, Michael A. Rudnicki
Journal: Cell Metabolism (2013)
Series Introduction: New directions in vaccine research
Authors: Peter Palese, Adolfo García-Sastre
Journal: Journal of Clinical Investigation (2002)

During the past 100 years, the widespread use of vaccines has begun to ameliorate the devastating effects of infectious disease, increasing the average life expectancy and enhancing the quality of life of those who have been vaccinated. During the 20th century, more than twenty vaccines were introduced, and in the US and Europe these vaccines dramatically curtailed (or nearly eliminated) diphtheria, tetanus, pertussis, measles, mumps, rubella, poliomyelitis, and diseases caused by Haemophilus influenzae type b. In addition, the global eradication of smallpox through vaccination has been one of the great triumphs of modern medicine.

Nevertheless, there are at least three reasons to renew our efforts to develop new and better vaccines. First, with the notable exception of smallpox, the organisms that cause most of these diseases continue to circulate in the population worldwide. Second, in addition to these persisting scourges, new diseases continue to emerge. Perhaps the most frightening example is AIDS, with its devastating effect on millions of people throughout the world. Third, as both scientists and the public have recently come to appreciate, the use of infectious agents as bioterrorist or biowarfare weapons represents a potent threat to individuals and society. Thus, there is an urgent need to maintain and improve vaccinations against circulating agents, to develop vaccines against emerging diseases, and to hone our ability to respond to novel biological threats, whether of natural or unnatural origins.
Common Fracture With Unusual Associated Vascular Injury
Authors: Otto E. Aufranc
Journal: JAMA (1965)

Dr. Richard Wohl: An 80-year-old female fell two days before her admission to the emergency ward at the Massachusetts General Hospital. Ten years previously she had suffered a cerebrovascular accident which caused a hemiparesis of the right side. She used a cane for assistance when walking. Except for mild hypertensive cardiovascular disease, she had no other serious illnesses. Physical examination revealed a moderately obese elderly female with a hemiparesis of the right side; she was in moderate distress due to pain in her right hip. With the exception of motor weakness and increased deep tendon reflexes on the right side, her general physical condition was unremarkable. However, shortening and external rotation of the right leg were noted. She complained of pain with all motions of her hip. Although both femoral and popliteal pulses were thought to be palpable bilaterally, the right popliteal pulse was recorded as only 1+. Both feet
THE EVALUATION OF SERODIAGNOSTIC TESTS FOR SYPHILIS IN THE UNITED STATES
Authors: H. S. CUMMING
Journal: JAMA (1934)

The development of a method for the evaluation of serodiagnostic tests for syphilis in the United States has recently been completed by a committee whose membership consists of two clinical pathologists appointed by the American Society of Clinical Pathologists, two syphilologists, and two officers of the United States Public Health Service. It has been the primary aim of this committee to be guided as far as possible by the most frequently employed, most practical, but also the most reliable, practices. Each step in the evaluation plan has been carefully considered with the idea of duplicating the actual procedure that occurs when the physician in private practice collects his specimens of blood and forwards them to a serologic laboratory for examination. It is believed to be the peculiar responsibility of serologists interested in the diagnosis of syphilis to develop thoroughly practical tests. They should be efficient from a diagnostic stand-point and
Difficulties in interpretation associated with substitution failure
Authors: Eric Zarahn
Journal: Behavioral and Brain Sciences (1999)

In one of their arguments against the radical neuron doctrine, Gold &amp; Stoljar (G&amp;S) use the idea that, in certain situations, equivalent terms may not be substitutable into statements that regard properties of the objects to which the terms refer. This device allows G&amp;S to refute the necessity of the conclusion that “the science of the mind equals the science of the brain” even though they take as a premise that the mind equals the brain. I argue, however, that this practice leaves the meaning of the “science of the mind” and the “science of the brain” indeterminate.
Prior use of inhaled corticosteroids was associated with less mortality in elders with COPD and pneumonia
Authors: Matthew B. Stanbrook
Journal: Annals of Internal Medicine (2012)

ACP Journal Club21 February 2012Prior use of inhaled corticosteroids was associated with less mortality in elders with COPD and pneumoniaMatthew B. Stanbrook, MD, PhDMatthew B. Stanbrook, MD, PhDUniversity Health Network, University of Toronto, Toronto, Ontario, Canada (M.B.S.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-4-201202210-02012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationChen D, Restrepo MI, Fine MJ, et al. Observational study of inhaled corticosteroids on outcomes for COPD patients with pneumonia. Am J Respir Crit Care Med. 2011;184:312-6. https://pubmed.ncbi.nlm.nih.gov/21512168Clinical Impact RatingsGIM/FP/GP: Hospitalists: Geriatrics: Pulmonology: Reference1 Singh S, Amin AV, Loke YK. Long-term use of inhaled corticosteroids and the risk of pneumonia in chronic obstructive pulmonary disease: a meta-analysis. Arch Intern Med. 2009;169:219-29. [PMID: 19204211] Google Scholar Author, Article, and Disclosure InformationAuthors: Matthew B. Stanbrook, MD, PhDAffiliations: University Health Network, University of Toronto, Toronto, Ontario, Canada (M.B.S.)This article was published at Annals.org on 7 February 2012. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPharmacological Therapy of COPD 21 February 2012Volume 156, Issue 4Page: JC2-12KeywordsChronic obstructive pulmonary diseaseHospitalizationsMortalityOutpatient clinicsPneumoniaSteroidsTreatment guidelinesVasopressorsVentilatorsVeteran care ePublished: 21 February 2012 Issue Published: 21 February 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Aldosterone and electrolyte movements in the colon.
Authors: O. Wrong
Journal: BMJ (1968)

BRITISH 379 contacts as necessary the district nurses, welfare officers, almoners, health visitors, and hospital ward sisters-all at the behest of the doctor, whose real job is thereby both enlarged and made easier.As general practice develops the doctor can fulfil his role only by having efficient and tolerant secretarial help, a practice nurse, good district nurses and midwives, and an up-to-date health visitor.There seems no reason why the last three should not be run by the local authorities across practice boun- daries as at present, but the first two are personal as regards duties and hours and can only be employed by the general practitioner himself.In spite of political interference this mode of practice developing in Britain is probably many years ahead of any arrangements offered in Europe or the North American continent.It will be a great pity if excessive demands reduce a practice nurse to the role of a " feldsher," when, losing the confidence of the public, general practice as we know it today will disintegrate.-Iam, etc., Coxheath, H. C.
CONTEMPO '87 Crushes Disturbs, Saddens, Amazes, and Disappoints
Authors: Mark A. Young, Eli D. Ehrenpreis
Journal: JAMA (1988)

<h3>To the Editor.</h3> —The Oct 23/30 issue of<i>JAMA</i><sup>1</sup>features an in-depth discussion of advances during the past year in a number of specialties. We were disturbed that the field of physical medicine and rehabilitation was not included in the issue. Physical medicine and rehabilitation is a dynamic and rapidly growing specialty. For example, the Graduate Medical Education National Advisory Committee recently predicted a need for 4060 physiatrists by 1990. To meet this demand there will need to be a doubling in the number of practicing physiatrists during the next four years (<i>Am Med News</i>, July 17,1987). There has been a wealth of recent advances in physical medicine and rehabilitation, including, for example, using electrical muscle stimulation for the treatment of hemiplegia, a promising therapy for a condition previously thought to be untreatable.<sup>2</sup> Physical medicine and rehabilitation is a specialty that works closely with internists and other primary
True delayed pressure urticaria induced by human Monotard insulin
Authors: C. M. E. Rowland Payne, C. Williams, I. V. Wilson
Journal: British Journal of Dermatology (1996)

Journal Article True delayed pressure urticaria induced by human Monotard insulin Get access C. M. E. Rowland Payne, C. M. E. Rowland Payne William Harvey Hospital Kennington Road Willesborough Ashford, Kent TN24 OLZ, U.K. Search for other works by this author on: Oxford Academic Google Scholar C. Williams, C. Williams William Harvey Hospital Kennington Road Willesborough Ashford, Kent TN24 OLZ, U.K. Search for other works by this author on: Oxford Academic Google Scholar I. V. Wilson I. V. Wilson William Harvey Hospital Kennington Road Willesborough Ashford, Kent TN24 OLZ, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 134, Issue 1, 1 January 1996, Page 184, https://doi.org/10.1111/j.1365-2133.1996.tb07867.x Published: 01 January 1996
Evaluating Peptide Mass Fingerprinting-Based Protein Identification
Authors: Senthilkumar Damodaran, Troy D. Wood, Priyadharsini Nagarajan, Richard A. Rabin
Journal: Genomics Proteomics & Bioinformatics (2007)

Abstract Identification of proteins by mass spectrometry (MS) is an essential step in proteomic studies and is typically accomplished by either peptide mass fingerprinting (PMF) or amino acid sequencing of the peptide. Although sequence information from MS/MS analysis can be used to validate PMF-based protein identification, it may not be practical when analyzing a large number of proteins and when high-throughput MS/MS instrumentation is not readily available. At present, a vast majority of proteomic studies employ PMF. However, there are huge disparities in criteria used to identify proteins using PMF. Therefore, to reduce incorrect protein identification using PMF, and also to increase confidence in PMF-based protein identification without accompanying MS/MS analysis, definitive guiding principles are essential. To this end, we propose a value-based scoring system that provides guidance on evaluating when PMF-based protein identification can be deemed sufficient without accompanying amino acid sequence data from MS/MS analysis.