tbuckley/cabot-search huggingface dataset:
Long‐term results of survival in patients with thalassemia major treated with bone marrow transplantation
Authors: Paolo Di Bartolomeo, Stella Santarone, Erminia Di Bartolomeo, Paola Olioso, Pasqua Bavaro, Gabriele Papalinetti, Paolo Di Carlo, Franco Papola, Antonio Nicolucci, Marta Di Nicola, Antonio Iacone
Journal: American Journal of Hematology (2008)

Abstract Allogeneic bone marrow transplantation (BMT) is the only available curative approach for thalassemia major, although long‐term morbidity and mortality are not established. The aim of this study was to assess the long‐term clinical and hematological results in children and adults with thalassemia major treated with BMT. We analyzed the outcome of 115 patients (median age 9 years, range 11 months to 28 years) with thalassemia major undergoing BMT from a related donor between 1983 and 2006. All patients received the same protocol, consisting of busulfan and cyclophoshamide as conditioning therapy and cyclosporin (CSA) alone or CSA and methotrexate for graft‐versus‐host disease (GvHD) prophylaxis. The cumulative probability of graft rejection was 6.7%. The transplant‐related mortality at 1 year was 8.7%. The 20‐year Kaplan‐Meier estimate of overall survival and disease‐free survival was 89.2% and 85.7%, respectively. Ninety‐nine patients out of 103 survivors were in excellent clinical and hematological conditions at last visit following a median follow‐up of 15 years (range, 1–24 years) with the exception of two patients who had invalidating chronic GvHD. This study conducted with a large cohort of patients and covering a long period of observation time, showed BMT to be curative for the majority of patients with thalassemia major. The impact of long‐term transplant‐related sequelae was very limited. Am. J. Hematol. 2008. © 2008 Wiley‐Liss, Inc.
Nonsteroidal Anti-inflammatory Drugs and High Blood Pressure
Authors: Ken Radack
Journal: Annals of Internal Medicine (1995)

Letters1 March 1995Nonsteroidal Anti-inflammatory Drugs and High Blood PressureKen RadackKen RadackUniversity of Cincinnati Medical Center, Cincinnati, OH 645267-0535. Princess Alexandra Hospital, Woolloongabba, 4102 Queensland, Australia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-5-199503010-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I was surprised by the recent meta-analysis by Johnson and colleagues [1] on nonsteroidal anti-inflammatory drugs (NSAIDs) and blood pressure. Several important aspects of the validity and generalizability of the study need serious attention before readers can apply the information.First, the “methodologic rigor” for individual studies was not very rigorous. For example, the study by Radack and colleagues [2] included 41 patients, not 30. The patients were predominantly black women (21 of 41 patients), not white (their Appendix Table 1), and the male-to-female ratio was 15:26, not 7:19 (their Appendix Table 1). We highlighted these differences ...References1. Johnson AG, Nguyen TV, Day RO. Do nonsteroidal anti-inflammatory drugs affect blood pressure? A meta-analysis. Ann Intern Med. 1994; 121:289-300. Google Scholar2. Radack KL, Deck CC, Bloomfield SS. Ibuprofen interferes with the efficacy of antihypertensive drugs. A randomized, double-blind, placebo-controlled trial of ibuprofen compared with acetaminophen. Ann Intern Med. 1987; 107:628-35. Google Scholar3. Radack KL, Deck CC. Do nonsteroidal anti-inflammatory drugs interfere with blood pressure control in hypertensive patients? J Gen Intern Med. 1987; 2:108-12. Google Scholar4. Grossberg GT. The pitfalls of meta-analysis (Editorial). J Am Geriatr Soc. 1990; 38:607. Google Scholar Author, Article, and Disclosure InformationAuthors: Ken RadackAffiliations: University of Cincinnati Medical Center, Cincinnati, OH 645267-0535. Princess Alexandra Hospital, Woolloongabba, 4102 Queensland, Australia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1995Volume 122, Issue 5Page: 397KeywordsBlood pressureClinical trialsDrugsMean arterial pressureNSAIDsPharmacoepidemiologyPrimary hypertensionResearch laboratories ePublished: 15 August 2000 Issue Published: 1 March 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Transvenous angioplasty of experimental branch pulmonary artery stenosis in newborn lambs.
Authors: J E Lock, T Niemi, S Einzig, K Amplatz, B Burke, J L Bass
Journal: Circulation (1981)

A dilatable form of bilateral branch pulmonary artery stenosis was created in 27 newborn lambs. Nine lambs were long-term survivors and were dilated with modified Grüntzig balloon dilation catheters. They were allowed to recover for 6-9 weeks, during which time there was no significant change in the mean systolic gradients across the narrowed sites. Thirteen arteries underwent dilation. Dilation was associated with a decrease in the systolic gradient in all cases (from 34.9 mm Hg to 8.1 mm Hg) and an increase in the diameter of the narrowed site (from 4.6 to 7.6 mm) as estimated by angiography. Flows and flow distribution were measured in four lambs before and after unilateral dilation using 15-mu radiolabeled microspheres; in each case, the fraction of total flow to the dilated lung rose after dilation (19.2 to 45.4%), as did the total flow to the dilated lung (30.0 to 69.2 ml/kg-min). Four lambs were catheterized every 2-4 weeks for an average of 16 weeks after dilation; the average gradient in these lambs remained below 10 mm Hg despite considerable growth (from 9.6 to 25.9 kg). Gross pathologic examination showed an intact vascular adventitia in all cases; there were multiple linear tears in the intima in recently (less than 7 days) dilated cases, but complete intimal healing had occurred by 2 months after dilation. No significant morbidity could be attributed to the dilation procedure. These results indicate that clinical trials are warranted.
The Effect of Streptokinase Infusion on Chronic Arterial Occlusions and Stenoses
Authors: Marc Verstraete, Joseph Vermylen, Maria Benedetta Donati
Journal: Annals of Internal Medicine (1971)

In 23 men with atherosclerosis of the distal abdominal aorta or more peripheral arteries, 35 arterial occlusions and 26 major arterial stenoses were visualized at angiography; these patients were treated with streptokinase using a standard dosage scheme. Twenty-eight of the 35 arterial occlusions were not modified by the thrombolytic therapy, 3 were totally and 4 partially lysed. In one patient complete removal of the obstruction was followed by reocclusion within 48 hr. The outcome appeared to be influenced by the duration, the length, and the location of the occlusion. Of the 26 major arterial stenoses, only 1 was definitely removed; another was transformed into a complete occlusion during streptokinase administration. Side effects of the therapy included 1 death, 7 instances of bleeding, 1 instance of thrombophlebitis, 1 case of bronchospasm, and 14 febrile reactions. Streptokinase therapy of chronic arterial occlusions and stenoses appears to be of limited value.
Toxicologic Emergencies: A Comprehensive Handbook in Problem Solving
Authors: Jay M. Arena
Journal: JAMA (1982)

As one who always found Dr Goldfrank's articles in the<i>Hospital Physician</i>journal informative and useful, I especially welcomed this expanded second edition of his handbook with eight contributors. The editors have compiled ten major sections and 46 case presentations, twice as many as in the first edition, which not only cover the primary toxicological problems of interest and concern, but also many of the current controversies in the management of acute and chronic poisoning. Major headings include "General Management of the Poisoned and Overdosed Patient," "Alcohol," "Analgesics," "Botanicals," "Toxic and Hallucinogenic Mushrooms," "Food and Plant Poisoning," "Cyanide," "Heavy Metals," "Insecticides," and "Mixed Problems." Also included are many other specific and general toxic drugs and chemicals. At the end of each chapter there is a list of suggested readings and ample references. A new segment of this second edition is the self-assessment section with 460 questions (ten per case study),
P1-275: Very elderly NSCLC patients above 75 years: Response to chemotherapy and improvement in Quality of Life is achievable to the same extent as for younger patients during platinum-based doublet chemotherapy
Authors: Jens B. Sørensen, Lene Bæksgaard, Anders Henriksen, Benedicte Hasselbalch, Katharina Perell, Jette Dandanell
Journal: Journal of Thoracic Oncology (2007)
Good Hospital Practice
Authors: John Lister
Journal: New England Journal of Medicine (1970)

THE efficient use of all kinds of medical resources becomes increasingly important with their rising cost and limited availability. In a system where the patient makes direct payment there is inevitably some restraint upon the doctor's actions in prescribing treatment of any kind, and although a state service may remove the immediately obvious financial barrier, there is a moral obligation on the doctor to be sure that without withholding of necessary treatment, his prescriptions are fully justified. For in effect the doctor has become the retailer of all types of medical care — a role that includes not only prescribing . . .
Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition
Authors: Erica L. McCoy, Ritsuko Iwanaga, Paul Jedlicka, Nee-Shamo Abbey, Lewis A. Chodosh, Karen A. Heichman, Alana L. Welm, Heide L. Ford
Journal: Journal of Clinical Investigation (2009)

Six1 is a developmentally regulated homeoprotein with limited expression in most normal adult tissues and frequent misexpression in a variety of malignancies. Here we demonstrate, using a bitransgenic mouse model, that misexpression of human Six1 in adult mouse mammary gland epithelium induces tumors of multiple histological subtypes in a dose-dependent manner. The neoplastic lesions induced by Six1 had an in situ origin, showed diverse differentiation, and exhibited progression to aggressive malignant neoplasms, as is often observed in human carcinoma of the breast. Strikingly, the vast majority of Six1-induced tumors underwent an epithelial-mesenchymal transition (EMT) and expressed multiple targets of activated Wnt signaling, including cyclin D1. Interestingly, Six1 and cyclin D1 coexpression was found to frequently occur in human breast cancers and was strongly predictive of poor prognosis. We further show that Six1 promoted a stem/progenitor cell phenotype in the mouse mammary gland and in Six1-driven mammary tumors. Our data thus provide genetic evidence for a potent oncogenic role for Six1 in mammary epithelial neoplasia, including promotion of EMT and stem cell–like features.
Linear Summation of Excitatory Inputs by CA1 Pyramidal Neurons
Authors: Sydney Cash, Rafael Yuste
Journal: Neuron (1999)

A fundamental problem in neurobiology is understanding the arithmetic that dendrites use to integrate inputs. The impact of dendritic morphology and active conductances on input summation is still unknown. To study this, we use glutamate iontophoresis and synaptic stimulation to position pairs of excitatory inputs throughout the apical, oblique, and basal dendrites of CA1 pyramidal neurons in rat hippocampal slices. Under a variety of stimulation regimes, we find a linear summation of most input combinations that is implemented by a surprising balance of boosting and shunting mechanisms. Active conductances in dendrites paradoxically serve to make summation linear. This "active linearity" can reconcile predictions from cable theory with the observed linear summation in vivo and suggests that a simple arithmetic is used by apparently complex dendritic trees.
Side-effect of Oral Contraceptives
Authors: N. L. Paros
Journal: BMJ (1964)

MEDICLNpatients was their unprompted admission that on this drug they felt generally better than previously.In my limited experience of this new hypo- tensive agent it would appear to be a potent and useful drug for the common types of hypertension.Individual dose requirements appear to be wide but considerably lower than found by Peart and MacMahon.The critical dose level is narrow and it should be administered cautiously, starting with 5 mg.b.d. and increasing the dose by 5 mg.b.d.every three to seven days until a satisfactory response is reached.The value of the drug is enhanced by its satisfactory hypotensive effect on the lying as well as the standing blood-pressure in all cases studied.-Iam, etc.,
Urinary tract infection in children.
Authors: W McKerrow, N Davidson-Lamb, P F Jones
Journal: BMJ (1984)

During 1968-77, 572 consecutive children with one or more positive urine cultures who were referred by their family doctors to one paediatric surgical outpatient clinic were investigated and prospectively recorded. An abnormality requiring treatment was found in 45%. The yield of positive findings and need for operation were greater in those referred after one infection than in those with recurrent infection. Among those under 2 years old 90% had an abnormality. One third of children with vesicoureteric reflux showed renal scarring at the time of first attendance. The results of medical and surgical treatment over five to 15 years of follow up were analysed. They emphasised the importance of culturing the urine whenever there may be urinary infection in a child and of investigating immediately those with a positive urine culture.
Commentary: Classification and cluster analysis
Authors: B S Everitt
Journal: BMJ (1995)

One of the most basic abilities of living creatures involves the grouping of similar objects to produce a classification. As well as being a basic human conceptual activity, classification is also fundamental to most branches of science. In chemistry, for example, the classification of the elements in the periodic table has had a profound impact on the understanding of the structure of the atom. Classification in medicine is equally important, with the classification of diseases being of primary concern as the basis for investigations of aetiology and treatment.

Statistical techniques for classification are essentially of two types. Members of the first type are used to construct a (hopefully) sensible and informative classification of an initially unclassified set of data; these are known as cluster analysis methods. The information on which the derived classification is based is generally …
Abstract 1121: Extracellular matrix-integrin B1 signaling is a major mediator of epithelial-to-mesenchymal transition and contributes to prostate cancer invasion and metastasis
Authors: Steven R. Bugiel, Elisabeth McKittrick, Huijun Zhao, Grant A. Howe, Christina L. Addison
Journal: Cancer Research (2014)

Abstract Within North America, prostate cancer is the most commonly diagnosed cancer in men with devastating implications deriving from metastasis, particularly those established in the bone. We have elucidated mechanisms by which prostate cancer undergoes metastasis with particular focus on the relationship between extracellular-matrix binding proteins, Integrin B1 (ITGB1) and epithelial-to-mesenchymal transition (EMT). Previous results in the laboratory suggested that prostate tumor cells depleted of ITGB1 were unable to form colonies in soft agarose and were impaired in their invasive abilities in vitro. In order to determine the possible mechanisms by which ITGB1 controlled these phenotypes, we performed numerous genetic techniques including siRNA targeted depletion of ITGB1 and subsequent profiling of pathway specific message RNA by RTqPCR to monitor the effects ITGB1 depletion on factors known to control EMT which is also associated with cell invasion. We found that prostate tumor cells depleted of ITGB1 had altered expression of numerous genes associated with EMT or cell invasion, many of which have been validated by RT-qPCR and western blot. In particular, a protease inhibitor SERPINE1 also known as Plasminogen Activator Inhibitor 1 (PAI-1) which is associated with EMT has been established as a target of ITGB1 regulation, in part via the ability of ITGB1 to regulate upstream factors associated with SERPINE1 expression such as TGFB2. Of particular interest to prostate cancer bone metastasis, we further found that collagen I interacting with ITGB1 significantly upregulated this pathway, and given the known role of EMT in mediating resistance to anti-cancer agents, this finding could help elucidate novel targets for the development of new drugs to treat prostate cancer bone metastasis. Citation Format: Steven R. Bugiel, Elisabeth McKittrick, Huijun Zhao, Grant A. Howe, Christina L. Addison. Extracellular matrix-integrin B1 signaling is a major mediator of epithelial-to-mesenchymal transition and contributes to prostate cancer invasion and metastasis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1121. doi:10.1158/1538-7445.AM2014-1121
Connective Tissue Diseases and the Heart
Authors: Mark G. Perlroth
Journal: JAMA (1975)

CONNECTIVE tissue disease is a term used to describe any one of a group of rheumatoid disorders of uncertain cause, which have overlapping clinical manifestations and may share common mechanisms of pathogenesis. The diseases included in the discussion are rheumatoid arthritis, systemic lupus erythematosus (SLE), progressive systemic sclerosis (PSS) (scleroderma), classic polyarteritis nodosa (PAN), polymyositis (dermatomyositis), ankylosing spondylitis, and Reiter syndrome. Acute rheumatic fever and chronic rheumatic heart disease are not discussed. This selection is necessarily arbitrary and is defended only by general familiarity with these diagnostic categories and their recognized potential for producing cardiac and pericardial lesions (Table). Diagnostic criteria and extracardiac manifestations of these diseases are summarized comprehensively elsewhere.<sup>1</sup> The most apparent external clinical manifestations of these disorders typically involve joints and skin. However, cardiac disease occurs as well and plays an important role in determining whether a patient with one of these diseases has a chronic
Randomized comparison of triple therapy and antithymocyte globulin induction treatment after simultaneous pancreas-kidney transplantation
Authors: Diego Cantarovich, Georges Karam, Magali Giral-Classe, Maryvonne Hourmant, Jacques Dantal, Gilles Blancho, Loïc Le Normand, Jean-Paul Soulillou
Journal: Kidney International (1998)
Efficacy of ursodeoxycholic acid in preventing cholestatic episodes in a patient with benign recurrent intrahepatic cholestasis
Authors: Giuseppe Maggiore, Costantino de Giacomo
Journal: Hepatology (1992)

Efficacy of ursodeoxycholic acid in preventing cholestatic episodes in a patient with benign recurrent intrahepatic cholestasisTo the Editor:We read with interest the paper by Crosignani and colleagues (1) demonstrating the inefficacy of ursodeoxycholic acid (UDCA) in preventing cholestatic episodes in a patient with benign recurrent intrahepatic cholestasis (BRIC).We would like to report a different experience with a 24-yr-old woman affected by BRIC and observed in our pediatric clinic since she was 7 yr old.The detailed clinical history has been reported previously (2).Briefly, she had, since 1970, seven attacks of cholestasis (one during her only pregnancy).Each was preceded, in the 2 wk before the onset of jaundice, by typical prodromic symptoms such as anorexia, fatigue, weight loss, insomnia, abdominal pain and pruritus.The average duration of jaundice during the seven attacks was 16 wk, and the average peak total bilirubin 18.5 mg/dl.A liver biopsy specimen during a symptomatic period at age 8 showed marked centrolobular and intracellular cholestasis.At age 14, cholangiography was conducted and was reported to be normal.During the years from 1977 to 1987 early administration of high-dose cholestyramine and phenobarbital failed to reduce the duration of the episodes of cholestasis.On no occasion did a prodromal period fail to evolve into an episode of cholestatic jaundice.In April 1988, she again experienced pruritus, anorexia, fatigue, marked weight loss and insomnia.Biochemical evidence of cholestasis was present (Table ).Treatment with 300 mg of UDCA twice a day was tentatively prescribed.Within 2 wk, all symptoms disappeared.After 2 mo, the dose of UDCA was tapered to 150 mg at bedtime and then gradually stopped.She was symptom-free during the successive 3 mo, then she again developed the usual prodromic features.She was again treated with UDCA, with a disappearance of symptoms and normalization of bilirubin values within 1 wk (Table ).During the last 4 yr, she has had no recurrence of cholestatic attacks.However, on two different occasions the occurrence of prodromic symptoms prompted us to prescribe UDCA successfully.In this patient UDCA treatment prevented recurrence of cholestatic episodes over a 4-yr period of follow-up.Our experience is in contrast with the very well-detailed report of Crosignani et al. (1) suggesting different biochemical mechanisms of canalicular cholestasis in BRIC.Moreover, UDCA treatment was recently re-3118139348
Electrocardiographic Changes Suggestive of Cardiac Ischemia in a Patient With Esophageal Food Impaction
Authors: John Yackee
Journal: JAMA (1986)

MANY patients presenting with chest pain initially believed to be cardiac in etiology may, in fact, have esophageal disease as an alternative or additional cause of their complaints. Although electrocardiographic (ECG) repolarization abnormalities have been well described in gastroenterologic processes, such as pancreatitis and cholecystitis,<sup>1</sup>and have been reported in esophageal disease,<sup>2-9</sup>the ECG is generally thought to be a reliable means of distinguishing between esophageal and cardiac pain.<sup>10,11</sup>In this report, we describe a patient who developed ECG changes suggestive of cardiac ischemia secondary to esophageal food impaction. <h3>Report of a Case</h3> A 57-year-old woman was admitted to the George Washington University Medical Center, Washington, DC, with a chief complaint of chest discomfort and dysphagia. She had a history of intermittent epigastric and substernal burning discomfort with meals, alleviated by antacids, and in 1979 was found to have a hiatal hernia with reflux by upper gastrointestinal
Shortness of Breath After a Choking Incident
Authors: Mourad H. Senussi, Hemantha Surath, Eduardo Mireles-Cabodevila
Journal: JAMA (2015)

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