tbuckley/cabot-search huggingface dataset:
Pathology and Treatment of Pain
Authors: J. Kilgour
Journal: BMJ (1851)

of any other morbid action, could be anywhere discovered.I do not pretend to assert that, in cases like the present, morbid appearances do not exist, but I am sure (and I write from a rather extensive experience) that in many instances it is very difficult to find them; and it is perhaps reserved for another age, and for more accurate and refined methods of investigation, to determine the nature of those subtle changes in the structure of the human brain, which derange the opera- tions of the intellect, and temporarily or permanently deprive man of the godlike faculty of reason.8, Tornington Square, August LS51.
Awareness during anaesthesia.
Authors: P. Ayre
Journal: BMJ (1969)

in which the subject of awareness during anaesthesia was discussed.Out of a total of 1,328 cases that I have recently anaesthetized, five cases have volunteered details of their operative experience indicating awareness.Three of these cases received nitrous-oxide-oxygen and relaxant anaesthesia-two out of a total of 25 caesarean sections and one case of multiple injuries.
Successful Gene Therapy for Severe Combined Immunodeficiency
Authors: Fred S. Rosen
Journal: New England Journal of Medicine (2002)

Infants with severe combined immunodeficiency are unable to mount an adaptive immune response, because they have a profound deficiency of lymphocytes. These babies usually die within a year from a sustained onslaught of opportunistic infections, but death can also be caused by immunization with live viral vaccines or with bacille Calmette–Guérin for the prevention of tuberculosis. Poliomyelitis, polioencephalitis, giant-cell pneumonia (caused by the measles virus), and fatal progressive vaccinia are other consequences of immunization of these infants. In fact, infants with severe combined immunodeficiency present a pediatric emergency to the physician; they can survive only if an immune system is . . .
MOLDED LUCITE® SURGICAL INSTRUMENTS
Authors: Frank T. Padberg
Journal: JAMA (1952)

At the suggestion of Dr. Loyal Davis, I have designed several instruments made of molded methyl methacrylate resin (lucites ® ) for use in neurosurgical operations. These include brain retractors, S-retractors, spoons, and a small mallet (fig. 1, 2, and 3). Lucite ® is available in transparent sheets in a variety of thicknesses, 0.06 to 0.25 in. (0.15 to 0.64 cm.). I have found the 0.125 in. (0.32 cm.) thickness to be the most desirable for making the retractors and spoons. Lucite ® is also obtainable in cylinders, which were used in making the mallet.  The patterns for the retractors and spoons were initially cut from the sheets of lucite ® with a band or jig saw, much as such patterns would be cut from plywood. Since lucite ® becomes soft and is easily molded when heated, these patterns were heated and then molded into the desired shapes. The brain retractors
Pulsed dose oxygen delivery system
Authors: J E COTES
Journal: Thorax (1999)

We agree with Richard Coker 1 that the vast majority of non-compliant cases of tuberculosis can be dealt with by a mixture of directly observed therapy (DOT) and inducements.However, when DOT fails in a few cases each year, despite intensive team eVort and carrots such as housing or food vouchers, the Public Health Act may have to be invoked.We have had recourse to this measure four times in the past six months but, though providing valuable breathing space, it is extremely costly and proved ineVectual as a solution each time.Once the patient is admitted there are still potential problems.Treatment cannot be enforced and patients can abscond.There have also been instances of patients assaulting staV, physically and sexually, issuing death threats, breaking hospital property, and terrorising other patients, even interfering with others' oxygen therapy.Dealing with such patients puts hospital staV and patients under unacceptable pressure and requires extra staYng for security purposes.NHS hospitals were not designed for, nor are they staVed adequately for, custodial purposes.There is an urgent need to review the Public Health Act and make provisions for small specialist units staVed by nurses with training in and an aptitude for interpersonal skills.Admission to the unit would usually only be required for short periods of time until precipitating circumstances were resolved and alternative arrangements made.The threat of compulsory admission, or a short period thereof, may induce a behavioural change in the patient, allowing DOT to be successful after failing previously.In addition, a centrally based mobile unit of trained staV could be available to help tide teams over emergencies and could reduce the need for the specialist unit, enabling more non-adherent patients to be managed in the community.We call upon the Department of Health to examine and implement these proposals.
Tc-99m Tetrofosmin A New Diagnostic Tracer for Parathyroid Imaging
Authors: MASATOSHI ISHIBASHI, HIDEMI NISHIDA, TSUTOMU KUMABE, SEIICHIRO MORITA, FUMIKA MATOBA, GAKUJI NOMURA, NAOFUMI HAYABUCHI
Journal: Clinical Nuclear Medicine (1995)

A 42-year-old woman with hyperparathyroidism had a CT scan that was suggestive of a small nodular lesion in the left lower neck. Tc-99m sestamibi and Tc-99m tetrofosmin parathyroid imaging were performed 10 minutes and 2 hours after tracer injection. Early imaging with Tc-99m sestamibi demonstrated thyroid and focal uptake in the left lower neck. On delayed imaging, findings suggested a parathyroid adenoma. Imaging with Tc-99m tetrofosmin demonstrated similar findings. The abnormal parathyroid gland was an adenoma.
Official Status of Homosexuality
Authors: Conrad Chyatte
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Action taken by the American Psychiatric Association in deleting homosexuality from the APA's official catalog of disorders counters influences toward paranoia. While paranoid tendencies are common in lesbianism, authorities who use Freudian theory to conclude that homosexual needs in themselves cause paranoid delusions seem to be mistaken. Psychometric data under study here from a group of 47 professional actors indeed do show that those men with exaggerated signs of paranoia are unusually feminine as well (η-correlation ratio =.71). However, the relationship is U-shaped; that is, actors who manifest the greatest femininity include both the most- and the least-paranoid members of the group. Those who readily accept their homosexuality are likely to escape the typical persecutory suspicion of the clandestines, appearing even less paranoid than heterosexually oriented actors. Manifestly, social measures against<i>any</i>activity (religious, political, and economic, as well as sexual) drive people to underground closets and
Evidence From Randomized Controlled Trials, Meta-analyses, and Subgroup Analyses
Authors: José A. Sacristán
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ACUTE APPENDICITIS WITH PYURIA
Authors: Malcom Thompson
Journal: JAMA (1928)

By a microscopic examination of a catheterized specimen of urine, acute appendicitis cannot always be differentiated from acute pyelitis. Given a patient with pain in the right side of the lower abdomen, nausea, vomiting, fever and leukocytosis, the diagnosis will most likely be acute appendicitis. Should a catheterized specimen of this patient's urine contain considerable pus, the condition will probably be acute pyelitis rather than acute appendicitis. For some time I was under the impression that operation should always be withheld in patients with suspected appendicitis and an associated pyuria because of the likelihood of pyelitis being the correct diagnosis. The impression was incorrect, as appendicitis and pyuria may be present at the same time and delaying the operation because of the pyuria may possibly cause a fatal outcome. Such patients should be carefully studied and the decision for or against operative treatment must depend on clinical judgment.
Peculiar HLA polymorphisms in Italian patients with primary biliary cirrhosis
Authors: Pietro Invernizzi, Pier Maria Battezzati, Andrea Crosignani, Francesca Perego, Francesca Poli, Alberto Morabito, Alejandro Espadas De Arias, Mario Scalamogna, Massimo Zuin, Mauro Podda
Journal: Journal of Hepatology (2003)
Protein Transduction Domain-mediated Delivery of QBP1 Suppresses Polyglutamine-induced Neurodegeneration In Vivo
Authors: H Akiko Popiel, Yoshitaka Nagai, Nobuhiro Fujikake, Tatsushi Toda
Journal: Molecular Therapy (2007)

Many neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and the polyglutamine (polyQ) diseases share common features including abnormal aggregation of misfolded proteins and their deposition as inclusion bodies in the brain. The polyQ diseases are caused by abnormal expansion of a polyQ stretch in each disease-causing protein, which triggers these proteins to form aggregates. We previously showed that genetic expression of the aggregate inhibitor peptide polyQ binding peptide 1 (QBP1) suppresses polyQ-induced neurodegeneration in Drosophila. However, to establish a molecular therapy using QBP1, QBP1 needs to be delivered into cells by its administration. In this study, we employed protein transduction domains (PTDs) to enable the efficient intracellular delivery of QBP1. We show here that fusion with a PTD enables the efficient intracellular delivery of QBP1, and that PTD-QBP1 treatment suppressed polyQ-induced cytotoxicity in cultured cells. Most importantly, oral administration of PTD-QBP1 successfully suppressed polyQ-induced premature death as well as polyQ inclusion body formation in a Drosophila model of the polyQ diseases, demonstrating its therapeutic effect against polyQ-induced neurodegeneration in vivo. Our study indicates that PTD-mediated delivery of aggregate inhibitor peptides is a promising therapeutic strategy for neurodegenerative diseases with abnormal aggregation of misfolded proteins. Many neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and the polyglutamine (polyQ) diseases share common features including abnormal aggregation of misfolded proteins and their deposition as inclusion bodies in the brain. The polyQ diseases are caused by abnormal expansion of a polyQ stretch in each disease-causing protein, which triggers these proteins to form aggregates. We previously showed that genetic expression of the aggregate inhibitor peptide polyQ binding peptide 1 (QBP1) suppresses polyQ-induced neurodegeneration in Drosophila. However, to establish a molecular therapy using QBP1, QBP1 needs to be delivered into cells by its administration. In this study, we employed protein transduction domains (PTDs) to enable the efficient intracellular delivery of QBP1. We show here that fusion with a PTD enables the efficient intracellular delivery of QBP1, and that PTD-QBP1 treatment suppressed polyQ-induced cytotoxicity in cultured cells. Most importantly, oral administration of PTD-QBP1 successfully suppressed polyQ-induced premature death as well as polyQ inclusion body formation in a Drosophila model of the polyQ diseases, demonstrating its therapeutic effect against polyQ-induced neurodegeneration in vivo. Our study indicates that PTD-mediated delivery of aggregate inhibitor peptides is a promising therapeutic strategy for neurodegenerative diseases with abnormal aggregation of misfolded proteins.
SUDDEN DEATH OF A CATATONIC PATIENT RECEIVING PHENOTHIAZINE
Authors: FRANK P. JOHNSON, DAVID A. BOYD, GEORGE P. SAYRE, FRANCIS A. J. TYCE
Journal: American Journal of Psychiatry (1964)

A case of sudden unforeseen death in a young, physically well, acutely catatonic patient has been presented. The findings at necropsy were not sufficient to explain either her death or her psychotic behavior. The terminal period was brief, lasting minutes. Contrastingly, sudden deaths in schizophrenic patients reported in the earlier literature generally were characterized by a terminal period lasting hours or days. The role of phenothiazines in the death of our patient is uncertain. Nonetheless, one should remain alert to the possibility of massive brain-stem inhibition occurring in patients receiving large doses of phenothiazines. The character of our patient's death closely simulates sudden death as described by several authors in physically well adults. These deaths were unrelated to medication and were considered as primarily the result of a physiologic or psychophysiologic hyperreactive state.
Abstract 1765: Recurrent fusion of NTRK1 in glioblastoma multiforme.
Authors: Jinkuk Kim, Hee-Jin Cho, Gye-Hyun Cho, Young-Hyeh Ko, Soonmyung Paik, Do-Hyun Nam
Journal: Cancer Research (2013)

Abstract Glioblastoma multiforme (GBM) is the most aggressive form of brain tumor, yet with no targeted therapy with substantial survival benefit. Recent studies on many types of solid tumors showed that fusion genes often play driver roles and are promising targets for pharmaceutical intervention. To survey potential fusion genes in GBM, we analysed RNA-Seq data from 162 GBM patients available through The Cancer Genome Atlas (TCGA). From the analysis, we identified recurrent fusion of neurotrophic tyrosine kinase receptor type 1 (NTRK1, also called TrkA) to the genes highly expressed in neuronal tissues, neurofascin (NFASC) and brevican (BCAN). NTRK1 is a mediator of the pro-survival signaling of nerve growth factor (NGF) and is a known oncogene, found commonly altered in human cancer. While GBMs largely lack NTRK1 expression, the fusion-positive GBMs express fusion transcripts in high abundance that retain NTRK1 kinase domain in frame. Analyses of the matching Exome-Seq data indicated that NFASC-NTRK1 fusion occurred through DNA-level rearrangement, whereas BCAN-NTRK1 fusion presumably occurred at RNA-level. As analogous NTRK1-fusions with thyroid-expressed genes were previously shown to drive thyroid cancer, NTRK1-fusion in GBM might have a similar role. Consistent with this hypothesis, the GBMs that harbor the NTRK1-fusion showed elevated NGF/NTRK1 pathway activity. About 1% of GBM patients are estimated to have NTRK1-fusion; these patients might benefit from potential NTRK1 inhibition therapies. Citation Format: Jinkuk Kim, Hee-Jin Cho, Gye-Hyun Cho, Young-Hyeh Ko, Soonmyung Paik, Do-Hyun Nam. Recurrent fusion of NTRK1 in glioblastoma multiforme. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1765. doi:10.1158/1538-7445.AM2013-1765 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
Pursuit of the Purple
Authors: Cecil J. Watson
Journal: JAMA (1966)

Let me acknowledge my keen sense of privilege in the invitation to initiate a lectureship which I understand is planned as an annual event. I am indeed grateful for this high honor.  I could scarcely expect my audience to be aware of my passion for color. If any of you might think that the title of my talk detects need of a spinalfluid Wassermann, please relax—I have only the straightforward intent of discussing first a small store of information blended from etymology, biography, and history and then a few more recent and perhaps more definitive observations. As we are well aware, etymology often melts insensibly with history at large. The search for the origin of a single word is likely to lead one backward through distant time and human events. For my part, a pursuit of this type adds zest to medical research.  Historical Aspects  If one may speak
Matrix metalloproteinase inhibition reduces adventitial thickening and collagen accumulation following balloon dilation
Authors: M Sierevogel
Journal: Cardiovascular Research (2002)

Constrictive arterial remodeling following balloon angioplasty has been related to adventitial collagen accumulation and subsequent thickening and can be prevented by matrix metalloproteinase (MMP) inhibition. Following balloon dilation, we examined the effect of MMP inhibition on collagen turnover and the relationship between adventitial area and degree of constrictive remodeling.In 12 non-atherosclerotic landrace pigs, balloon dilation was performed in 39 peripheral arteries with and without MMP inhibition. Follow up with intravascular ultrasound was performed at 42 days. Collagen content was quantified using polarized light and digital image microscopy. Procollagen expression was determined using immunochemistry and Western blotting.In the MMP inhibitor group, constrictive remodeling was inhibited at 42 days follow up. In control and MMP inhibitor groups, a positive relation was observed between adventitial thickness and degree of constrictive remodeling (P<0.001). Adventitial thickening and adventitial collagen content were reduced in the MMP inhibitor group (P=0.002 and P=0.001, respectively). Procollagen immunostaining, but not protein analysis on Western blotting, was decreased in the MMP inhibitor group.MMP inhibition impaired adventitial thickening by reduction of collagen content 42 days after balloon dilation. This might explain its inhibitory effect on constrictive remodeling.
THE AMINO ACID SEQUENCE OF HYPERTENSIN II
Authors: Leonard T. Skeggs, Kenneth E. Lentz, Joseph R. Kahn, Norman P. Shumway, Kenneth R. Woods
Journal: The Journal of Experimental Medicine (1956)

The amino acid sequence of horse hypertensin II has been determined by the use of chymotrypsin, the fluorodinitrobenzene method, and stepwise phenylisothiocyanate degradation. The results indicate that the amino acids of hypertensin II are arranged in the following order: asp-arg-val-tyr-iso-hist-pro-phe.
IMPROVEMENT OF HEART FAILURE WITH PRESERVED EJECTION FRACTION IN OBESE INDIVIDUALS FOLLOWING GASTRIC BYPASS SURGERY
Authors: Mohammed Saghir, Ali Jamal, Robert O&apos;Connor, Adil Bashir, Sandor J. Kovacs, Andrew R. Coggan, Cylen Javidan-Nejad, Woodard Pamela, J. Christopher Eagon, Linda R. Peterson
Journal: Journal of the American College of Cardiology (2012)
Tissue-regulated differentiation and maturation of a v-abl-immortalized mast cell-committed progenitor
Authors: Michael F. Gurish, Warren S. Pear, Richard L. Stevens, Martin L. Scott, Karen Sokol, Namit Ghildyal, Matthew J. Webster, Xuzhen Hu, K. Frank Austen, David Baltimore, Daniel S. Friend
Journal: Immunity (1995)
Diagnosis and Treatment of Pericardial Effusion Without Pericardiocentesis: Use of Steroids and Diuretics.
Authors: R. Bruce Logue
Journal: Annals of Internal Medicine (1968)

s1 May 1968Diagnosis and Treatment of Pericardial Effusion Without Pericardiocentesis: Use of Steroids and Diuretics.R. Bruce Logue, Dean R. Taylor, Locke Y. CarterR. Bruce LogueSearch for more papers by this author, Dean R. TaylorSearch for more papers by this author, Locke Y. CarterSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1158_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough steroids are widely used in the control of pain, fever, and systemic symptoms due to pericarditis, then usefulness as a diagnostic and therapeutic agent in pericarditis with effusion has not been emphasized. Steroids alone may result in resolution of pericardial effusion, and when combined with diuretics, the effect may be enhanced. The combination of steroids with diuretics is useful [1] in the recognition of pericardial effusion, [2] in prevention and management of pericardial tamponade, [3] in differentiation of pericardial effusion from myocarditis and diffuse myocardial disease, [4] to prevent the need for pericardiocentesis or open drainage of the pericardium,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Atlanta, Georgia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1158-1158KeywordsDiureticsFeversHyperthermiaMyocarditisPericardial diseasesPericardiumSteroids Issue Published: 1 May 1968 PDF DownloadLoading ...
The natural course of chronic hepatitis C: A comparison between patients with genotypes 1 and 2 hepatitis C viruses
Authors: M Kobayashi
Journal: Hepatology (1996)

This study was conducted to clarify if the long-term histological outcome among patients with chronic hepatitis C differs according to whether they are infected with genotype 1 or 2 hepatitis C virus (HCV). We examined 140 patients with chronic hepatitis C. The HCV genotype was determined by the enzyme-linked immunosorbent assay (ELISA) based on genotypes 1 and 2 specific recombinant proteins; genotype 1 was found in 100 patients (96 were 1b and 4 were indeterminate) and genotype 2 in 36. The two groups showed no significant difference for any clinical background features. Deterioration of the grade of liver histology during the follow-up period was seen in 68.0 percent of the patients with genotype 1 as compared with 41.7 percent of those with genotype 2 (P < .01). Similarly, the deterioration of the stage of liver histology was more common in the former group than in the latter (63.0 percent and 38.9 percent respectively; P < .05). The mean serum HCV-RNA titer was significantly higher in the patients with genotype 1 than in those with genotype 2 (P < .001), and multivariate analysis showed the titer was one of the independent factors of the deterioration of the stage (P = .0044). This phenomenon may be related in part to the difference in pathogenicity between the two HCV genotypes. In conclusion, our results suggest that more severe progression of chronic hepatitis C is seen in patients showing genotype 1b compared with those with genotype 2.