tbuckley/cabot-search huggingface dataset:
Rose and Carless Manual of Surgery
Authors: Robert D. Bickel
Journal: JAMA (1961)

This excellent textbook of surgery, should serve as a dependable guide to the student of surgery and to the practitioner. It has a good index and an interesting biography of each of the original authors. The text material has been prepared by 15 well known British specialists. The color plates are excellent. The first section includes chapters on surgical infections, chemotherapy, wounds and burns, water and electrolyte balance, shock, blood transfusions, malignant diseases, and diseases of the skin and lymphatic systems. The remaining sections include orthopedic surgery, surgery of the nervous system, surgery of the head and neck, surgery of the alimentary tract, and surgery of the genito-urinary system. These are of a style and content that make the book suitable for ready reference.
Human Tissue Act.
Authors: P. H. Addison
Journal: BMJ (1968)

subheadings, so that all the drugs of similar action were to be found together.The antidepressives are a case in point.Instead of all antidepressives being listed alphabetically, as in MIMS, Medindex classified them into monoamine oxidase inhibitors, thymoleptics, and others.Other useful sections were the paragraphs of indications and safety factors at the beginning of each section, and the index of official and other approved names.I am sure there must be many general practitioners who regret the passing of Medindex as much as I do.
Corepressor Rcor1 is essential for murine erythropoiesis
Authors: Huilan Yao, Devorah C. Goldman, Tamilla Nechiporuk, Sunita Kawane, Shannon K. McWeeney, Jeffrey W. Tyner, Guang Fan, Marc A. Kerenyi, Stuart H. Orkin, William H. Fleming, Gail Mandel
Journal: Blood (2014)
Psychological and social evaluation in cases of deliberate self-poisoning seen in an accident department.
Authors: R Gardner, R Hanka, S J Roberts, J M Allon-Smith, A A Kings, R Nicholson
Journal: BMJ (1982)

The outcome in 115 consecutive patients with mild self-poisoning seen by junior medical staff and discharged from the accident department was compared with that of 98 similar patients admitted to the medical wards. Psychiatrists saw only four patients in the accident department and 25 admissions. In making their assessments the junior medical staff considered psychosocial factors as well as the patients9 physical condition. Most patients recommended for further care, and discharged from the accident department, subsequently received it. Repetition rates were similar in the two groups and there had been no suicides when patients were followed up at one year. It is feasible for junior staff in an accident department to decide whether patients with self-poisoning need admission or may be discharged with or without subsequent referral for psychiatric or social work help.
Hodgkin Disease and HIV
Authors: Umberto Tirelli
Journal: Annals of Internal Medicine (1993)

Letters15 February 1993Hodgkin Disease and HIVUmberto Tirelli, MD, Diego Serraino, MD, and Antonio Carbone, MDUmberto Tirelli, MD, Diego Serraino, MD, and Antonio Carbone, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-4-199302150-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Hessol and colleagues reported a significantly greater incidence of Hodgkin disease in homosexual men with HIV infection [1]. An additional aspect not mentioned by them is the apparent high prevalence of the mixed cellularity (MC) and lymphocyte depletion (LD) subtypes of Hodgkin disease in patients with HIV infection [2]. We compared the distribution of histologic subtypes of Hodgkin disease among 92 patients with HIV infection, 75 of whom were intravenous drug users, collected within the network of the Italian Group on AIDS and Tumors (GICAT) with that seen among patients without HIV infection. The HIV-infected patients had ...References1. Hessol NA, Katz MH, Liu JY, Buchbinder SP, Rubino CJ, Holmberg SD. Increased incidence of Hodgkin disease in homosexual men with HIV infection. Ann Intern Med. 1992; 117:309-11. Google Scholar2. Tirelli U, Vaccher E, Rezza G, Broccia G, Fassio PG, Gobbi M, et al. Hodgkin's disease and infection with the human immunodeficiency virus in Italy. Ann Intern Med. 1988; 309-10. Google Scholar3. Serraino D, Franceschi S, Talamini R, et al. Socio-economic indicators, infectious diseases and Hodgkin's disease. Int J Cancer. 1991; 47:352-7. Google Scholar4. Henry-Amar M. Workshop statistical report. In: Somers R, Henry-Amar M, Meerwaldt JK, Carde P; eds. Treatment Strategy in Hodgkin's Disease. Paris: Les Editions INSERM; 1990:169-90. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLymphoma in Other DiseasesHodgkin's Disease in Patients Infected with Human Immunodeficiency Virus: Frequency, Presentation and Clinical OutcomeRisk of cancer in people with AIDSAIDS‐Related MalignanciesMalignant tumors and AIDS 15 February 1993Volume 118, Issue 4Page: 313-314KeywordsAIDSAddictsCase seriesChemotherapyHIV infectionsHodgkin lymphomaHomosexualsImmunodeficienciesLymphocytes Issue Published: 15 February 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Haemolytic Anaemia Following Thrombocytopenic Purpura
Authors: J. N. Harris-Jones, D. M. McLellan, G. Owen
Journal: BMJ (1958)

POLIOMYELITIS VACCINE 'DJBRmSH pre-existing heterologous antibody may show an in- creased response to a given type, while those with pre- existinghomologousantibodygive a "booster" response.
Analysis of cell cycle characteristics and course of the disease in ANLL
Authors: Azra Raza, Yogesh Maheshwari, William Brereton, Harvey D. Preisler
Journal: American Journal of Hematology (1987)

The cell cycle characteristics of a newly diagnosed patient with acute nonlymphocytic leukemia (ANLL) were studied by using intravenous bromodeoxyuridine (BrdU) and our previously described "double-label" technique. The percentage of S-phase cells in the bone marrow (BM) biopsy were 25% compared to 7% from the simultaneously obtained BM aspirate. The duration of S-phase (Ts) was determined to be 4 hr and the total cell cycle time (Tc) was 16 hr. We demonstrated that the actual clinical course of this patient's illness corresponded well with the course predicted on the basis of these cell cycle measurements. Although he achieved aplasia in response to two successive courses of induction chemotherapy, leukemic cells repopulated the marrow, producing a rapidly rising PB white blood cell (WBC) count with a T1/2 of approximately 20 hr each time. It is likely that the resistance of this patient's leukemia to therapy was a result of the rapid proliferative rate of his leukemic cells and not due to the inability of chemotherapeutic agents to kill a large number of cells. Since the measurements can be completed within 48 hr, measuring Ts and Tc will provide a better understanding of the biological differences that exist between patients with ANLL.
From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors
Authors: Peer Wulff, Thomas Goetz, Elli Leppä, Anni-Maija Linden, Massimiliano Renzi, Jerome D Swinny, Olga Y Vekovischeva, Werner Sieghart, Peter Somogyi, Esa R Korpi, Mark Farrant, William Wisden
Journal: Nature Neuroscience (2007)
Electrocardiographic findings in patients with obstructive and nonobstructive hypertrophic cardiomyopathy.
Authors: D D Savage, S F Seides, C E Clark, W L Henry, B J Maron, F C Robinson, S E Epstein
Journal: Circulation (1978)

One hundred and thiry-four patients with hypertrophic cardiomyopathy were evaluated by standard 12-lead electrocardiography. Normal electrocardiograms were extremely uncommon, occurring in less than 7% of each subgroup of patients (i.e., those with or without either symptoms or obstruction to left ventricular outflow), with the exception of those who were both asymptomatic and had no left ventricular outflow obstruction. Even in this subgroup, however, normal electrocardiograms occurred in only 27% of patients. Repolarization abnormalities and left ventricular hypertrophy were the most common abnormalities, occurring in 81% and 62%, respectively, of the total population. A broad spectrum of other electrocardiographic abnormalities was found, but none was unique to hypertrophic cardiomyopathy. Patients with vs those without electrocardiographic left ventricular hypertrophy or left atrial abnormality had significantly (P less than 0.005) greater mean ventricular septal thickness (22 +/- 0.6 vs 19 +/- 0.6 mm) and left atrial dimension (48 +/- 1 vs 40 +/- 1 mm) measured by echocardiography, and signficantly (P less than 0.01) higher mean pulmonary capillary wedge pressure (16 +/- 1 vs 10 +/- 1 mm Hg) and left ventricular end-diastolic pressure (20 +/- 1 vs 15 +/- 1 mm Hg). The high prevalence and diverse nature of electrocardiographic abnormalities suggest that any patient with an unusual and unexplained electrocardiogram should be suspected of having hypertrophic cardiomyopathy even if the physical examination is normal, as is often the case in patients without obstruction.
Alcohol is an important co-factor for both steatosis and fibrosis in Northern Italian patients with chronic hepatitis C
Authors: Paolo Fabris, Annarosa Floreani, Antonio Carlotto, Maria Teresa Giordani, Vincenzo Baldo, Clara Stecca, Lorella Marchioro, Andrea Tramarin, Tosca Bertin, Francesco Negro, Fausto de Lalla
Journal: Journal of Hepatology (2004)
Book Review Sex Differences in the Brain: From Genes to Behavior Edited by Jill B. Becker, Karen J. Berkley, Nori Geary, Elizabeth Hampson, James P. Herman, and Elizabeth A. Young. 480 pp., illustrated. New York, Oxford University Press, 2008. $98.50. 978-0-19-531158-7
Authors: Tara Perrot-Sinal
Journal: New England Journal of Medicine (2008)
Ultrasonography of the Abdomen
Authors: Ann Maravilla
Journal: JAMA (1977)

Ultrasonography requires an intimate knowledge of the methodology before one can accurately interpret scans. Books can only serve to orient the physician toward attaining basic skills or enabling him to more readily comprehend the information given by his consultant. This new text by Hassani admirably fulfills both purposes. A large segment is devoted to the physical principles, the machinery, and the basic techniques. It is a simple, practical chapter needed before one can turn to the scans themselves. The emphasis lies with B-mode gray-scale techniques, the scans that are currently the most popular. Conventional B-mode is always discussed but plays a minor role. The concepts of A-mode and M-mode are introduced, but the ability to use them cannot be readily obtained except through experience, so they are of necessity de-emphasized. The remainder of the text is divided by body regions. Chapters are devoted to hepatic sonography (liver, gallbladder, and biliary
Thrombocytopenia and Alcoholism
Authors: ROBERT M. POST
Journal: Annals of Internal Medicine (1968)

Eight patients with acute and chronic alcoholism and liver disease, who suffered one or more episodes of acute thrombocytopenic purpura after heavy alcoholic intake, are described. Recovery was rapid after withdrawal from alcohol, and the use of corticosteroids did not appear to alter their course. Folic acid deficiency, splenic pooling of platelets, and massive hemorrhage do not appear to be causal factors. The possible role of excessive coagulation and a direct effect of alcohol on the bone marrow or circulating platelet are discussed.
Thyroid function in fetuses with chromosomal abnormalities: Authors' reply
Authors: J G Thorpe-Beeston, K H Nicolaides, D L Ewins, C M Gosden, A M McGregor
Journal: BMJ (1991)

The most potential harm, however, lies in the drug's selective serotoninergic toxicity and its dopaminergic actions,4 and the suggestion that it might induce psychosis de novo deserves further research.
Repression of human γ-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter
Authors: Quan Zhao, Wenlai Zhou, Gerhard Rank, Rosemary Sutton, Xi Wang, Helen Cumming, Loretta Cerruti, John M. Cunningham, Stephen M. Jane
Journal: Blood (2005)
Role of Vector in Activation of T Cell Subsets in Immune Responses against the Secreted Transgene Product Factor IX
Authors: Paul A. Fields, Dariusz W. Kowalczyk, Valder R. Arruda, Elina Armstrong, Mark L. McCleland, J.Nathan Hagstrom, K.John Pasi, Hildegund C.J. Ertl, Roland W. Herzog, Katherine A. High
Journal: Molecular Therapy (2000)

Defining immune responses against the secreted transgene product in a gene therapy setting is critical for treatment of genetic diseases such as hemophilia B (coagulation factor IX deficiency). We have previously shown that intramuscular administration of an adeno-associated viral (AAV) vector results in stable expression of therapeutic levels of factor IX (F.IX) and may be associated with humoral immune responses against F.IX. This study demonstrates that intramuscular injection of an AAV vector expressing F.IX fails to activate F.IX-specific cytotoxic T lymphocytes (CTLs) in hemostatically normal or in hemophilia B mice, so that there is an absence of cellular immune responses against F.IX. However, transgene-derived F.IX can cause B cell responses characterized by production of T helper cell-dependent antibodies (predominantly IgG1, but also IgG2 subclasses) resulting from activation of CD4+ T helper cells primarily of the Th2 subset. In contrast, administration of an adenoviral vector efficiently activated F.IX-specific CTLs and T helper cells of both Th1 and Th2 subsets, leading to inflammation and destruction of transduced muscle tissue and activation of B cells as well. Therefore, vector sequences fundamentally influence T cell responses against transgene-encoded F.IX. In conclusion, activation of the immune system in AAV-mediated gene transfer is restricted to pathways mediated by F.IX antigen presentation through MHC class II determinants resulting in T and B cell responses that are more comparable to responses in the setting of protein infusion rather than of viral infection/gene transfer.
Tc-99m Sestamibi Scintimammography in the Mammographically Dense Breast
Authors: HARRY ZEGEL, LLOYD HELLER, STEVEN EDELL, FREDRIC SQUIRES, JONATHAN RUBIN
Journal: Clinical Nuclear Medicine (1999)

Purpose The mammographically dense breast or the “difficult-to-interpret mammogram” poses significant clinical and diagnostic imaging concerns. From our experience using Tc-99m sestamibi mammography in more than 650 patients, we share our experience in a pictorial manner and include suggested indications and limitations of this exciting new technique. Examples of Tc-99m sestamibi imaging in six patients with mammographically dense breasts are presented. Materials and Methods All patient examinations were ordered clinically for various indications. Comparison radiographic mammography and, when available, confirmatory pathologic analysis were also done. The examples were chosen from our experience with more than 650 patients at two university hospitals and one outpatient imaging center. Results Of the six examples presented, four had cancer, one had fibrosis after chemotherapy for ductal cell carcinoma, and one had no evidence of cancer. Tc-99m sestamibi imaging showed no increased uptake in the one patient with no tumor and various degrees of uptake in the other five patients. Conclusions Six examples from our clinical experience show the usefulness of Tc-99m sestamibi imaging in patients with mammographically dense breasts. The ability to identify a malignancy or its absence supports the continued use of this procedure in these patients.
Foundation programme for newly qualified doctors
Authors: Richard Hays
Journal: BMJ (2005)

Should improve specialist training in the UK but may lack capacity 

Born of necessity, developed with remarkable consensus, and piloted successfully for a year, the United Kingdom's new foundation programme for medical graduates has been launched.1 The programme aims to ensure that all entrants to formal postgraduate specialist training have met the standards required to progress to that particular phase of lifelong learning.2 Opinions vary about the role of these reforms and their impact on the medical education system and workforce.

The programme focuses on performance in the workplace, rather than only knowledge and skills, largely in response to recent scandals that highlighted problems with clinical governance, professional teamwork, and practitioners' honesty. The core competencies required to complete the programme match those laid down by the General Medical Council in Good Medical Practice and reflect reasonable expectations of the ability of junior medical practitioners.3 Although the UK may be the first to formalise such a system, similar moves are being discussed in other places with similar systems of medical education and career progress.

The introduction of such programmes should not imply …
789-3 Does 99mTc-Sestamibi Gated-SPECT Provide Additional Information Over Ungated-Sestamibi and 201-TI Reinjection Imaging in Viability Assessment?
Authors: Raffaele Giubbini, Elisa Milan, Orazio Zoccarato, Marco Metra, Federica Ettori, Omelia Leonzi, Luigi Niccoli, Ami S. Iskandrian
Journal: Journal of the American College of Cardiology (1995)
Basophils in tuberculin and "Jones-Mote" delayed reactions of humans.
Authors: P W Askenase, J E Atwood
Journal: Journal of Clinical Investigation (1976)

Jones-Mote reactions are delayed, erythematous, and mildly indurated cutaneous reactions originally described in humans sensitized by skin injection of heterologous proteins. Similar reactions in guinea pigs contain many basophils and are called cutaneous basophil hypersensitivity. In contrast, guinea pigs immunized with mycobacterial adjuvants have classical tuberculin-type delayed hypersensitivity reactions, which contain few basophils. This has led to a new classification of delayed responses, based largely on the presence or absence of basophils. We induced sensitization for Jones-Mote reactions in 20 normal humans by intradermal injections of keyhole limpet hemocyanin. Skin tests with KLH 1 wk later showed erythematous and indurated delyaed reactions in all subjects. Rebuck skin windows showed specific accumulations of basophils with a delayed time-course in 18 of 20 subjects. In 12 normals sensitized with oxazolone-keyhole limpet hemocyanin conjugates, skin reactions and in vitro lymphocyte stimulation showed carrier and not hapten specificity, suggesting that cutaneous responses were probably mediated by T cells. A comparative study of strongly positive PPD skin tests in patients with tuberculosis showed significant basophil accumulations in five of nine subjects. Thus, basophils occurred in human tuberculin and Jones-Mote reactions and were not a distinguishing feature of Jones-Mote reactions. We suggest that the occurrence of basophils at delayed reactions is under complex regulation and that basophil accumulations are an aspect of delayed hypersensitivity, rather than an indication of a distinctive and separate response.
One Way 'the Latest Health News' May Benefit Patients Through Physicians' Response
Authors: Marsha F. Goldsmith
Journal: JAMA (1988)

HEARTS MAKE NEWS, not only when they're palpitating with political passion but increasingly nowadays because they're revealing their secrets to science. As researchers learn more about such vital topics as the relationship of cholesterol levels and cardiovascular disease, the role of stress in hypertension, and the efficacy of aspirin for preventing myocardial infarction, the news media excitedly relay their pronouncements to the public—frequently with the caveat "before you attempt to apply this information to yourself, see your physician." Using the information may well be a good idea for several reasons, not only the obvious one of self-preservation. The bill for cardiovascular disease—the number one cause of death in this country, with 1 million fatalities attributed to it annually—in the United States is thought to have approximated $85 billion last year (<i>JAMA</i>1988;259:786), including $71 billion in direct health expenses and the rest owing to the indirect costs of disabling and
Evaluation of Screened Blood Donations for Human Immunodeficiency Virus Type 1 Infection by Culture and DNA Amplification of Pooled Cells
Authors: Michael P. Busch, Bernard E. Eble, Hassan Khayam-Bashi, David Heilbron, Edward L. Murphy, Shirley Kwok, John Sninsky, Herbert A. Perkins, Girish N. Vyas
Journal: New England Journal of Medicine (1991)

Reports of transmission of the human immunodeficiency virus type 1 (HIV-1) from transfusions of screened blood and reports of silent, antibody-negative HIV-1 infections in persons at high risk continue to foster concern about the safety of the blood supply. Previous estimates of the risk of HIV-1 range from 1 in 38,000 to 1 in 300,000 per unit of blood but are based on either epidemiologic models or the demonstration of sero-conversion in recipients.
Primary Prevention of Diabetes Mellitus
Authors: Jaakko Tuomilehto, Eva Wolf
Journal: Diabetes Care (1987)

Diabetes mellitus is one of the chronic noncommunicable diseases that have increased markedly in this century. The discovery of insulin and other drugs for lowering hyperglycemia have certainly reduced mortality from acute complications of diabetes and improved the quality of life of many diabetic patients. Recent advances in research into the etiology and natural history of diabetes have increased our knowledge about different types of diabetes to such an extent that primary prevention of diabetes mellitus is becoming a reality. Until now, few studies have attempted to test measures for primary prevention of diabetes. Therefore, the data supporting the possibility for primary prevention are largely indirect and need to be tested in preventive trials or in community-based prevention programs. We believe, however, that the time is right to start action in populations in which the prevalence of diabetes is known to have clearly increased recently. We summarize the evidence that can be used as the scientific basis of primary prevention of diabetes mellitus.
Cardiovaurular Reflex Control in Health and Disease.
Authors: A Murray
Journal: Cardiovascular Research (1994)

Journal Article Cardiovaurular Reflex Control in Health and Disease. Get access A Murray A Murray Newcastle upon Tyne, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 11, November 1994, Page 1736, https://doi.org/10.1093/cvr/28.11.1736a Published: 01 November 1994