tbuckley/cabot-search huggingface dataset:
Dental Therapy During Anticoagulant Therapy
Authors: A. M. Ziffer
Journal: JAMA (1961)

<h3>To the Editor:</h3> Reference is made to the article by Behrman and Wright, "Dental Surgery During Continuous Anticoagulant Therapy" (<i>JAMA</i><b>175:</b>483 [Feb. 11] 1961), in which the authors state that my report of experience with 2 patients "appears to have been unduly alarming." Our 2 patients, both maintained at hypoprothrombinemic levels within the range recommended by Dr. Wright, underwent dental extraction performed by the chief of the dental service of a VA hospital. In both our patients, bleeding could only be controlled by returning the prothrombin level to normal by the use of vitamin K<sub>1</sub>oxide. In view of a fall in the hemoglobin level from 14.0 to 7.1 gm. per 100 cc. before appropriate therapy was instituted, we feel that 1 patient might have died of exsanguination. It should be emphasized that this same patient who hemorrhaged profusely following 2 separate extractions under hypoprothrombinemia had no difficulty
Colorectal cancer detected up to 5 years after a 'normal' colonoscopy/ flexible sigmoidoscopy
Authors: H. Padmanabhan, D. Taunk, G. Townson
Journal: Gut (2011)

<h3>Introduction</h3> Lower GI endoscopy has replaced barium enema as the primary method for diagnosis of colorectal cancer (CRC), but has an inherent miss rate. The aim was to estimate how frequently lower GI endoscopy might have failed to detect cancer during the 5 years preceding a final diagnosis of CRC. <h3>Methods</h3> 273 patients were identified from cancer registry with CRC from April 2007 to March 2009. Records were reviewed for the results of colonoscopy and flexible sigmoidoscopy 6 months to 5 years prior to their diagnosis of cancer. <h3>Results</h3> Among the 273 patients, we identified 10 patients (3.7%) who had colonoscopy and /or flexible sigmoidoscopy that had not shown CRC prior to the final diagnosis. In the missed cancer group three cases were incomplete and eight were false negative with a median diagnostic delay of 36 months (range 12–60). 70% of the missed cancer group were diagnosed with Dukes9 C colon cancer and 30% presented with emergency complications. <h3>Conclusion</h3> A recent study by Bressler <i>et al</i> suggested that up to 4% of cancers may be missed at colonoscopy. Our miss rates are in line with previous studies. The reasons why cancers were missed relate to incomplete colonoscopy, poor bowel preparation, inadequate technique, prior incomplete polypectomy, failure to recognise flat lesions, misinterpretation of what was seen and failure to arrange alternative tests in patients with incomplete tests.
Value of Histamine Skin Tests in Meniere's Disease
Authors: M. Haggie
Journal: BMJ (1951)

In 1861 Prosper Meniere (1861a, 1861b) described the disease that bears his name.Little has since been added to his description of apoplectic attacks of vertigo occur- ring in association with tinnitus and variable but pro- gressive deafness.He suggested that the condition arose in a previously healthy ear, and that the semicircular canals were the site of the functional disturbances.Seventy-seven years later the careful histological studies
Adult Respiratory Distress Syndrome Complicating Severely Uncontrolled Diabetes Mellitus: Report of Nine Cases and a Review of the Literature
Authors: Patrica Carroll, Robert Matz
Journal: Diabetes Care (1982)

We report the occurrence of the adult respiratory distress syndrome (ARDS) in association with uncontrolled diabetes in nine patients. In reviewing the literature we found nine similar cases reported in little over a decade. In most cases no condition known to precipitate ARDS was discovered. The evidence suggests that the severely uncontrolled diabetic state in some way may initiate pathologic events leading to the capillary leak of ARDS. This description of the association of these two entities not commonly recognized as occurring simultaneously has important clinical implications: the entity should be anticipated in uncontrolled diabetic patients who present with acidosis, hypotension, hypothermia, and/or coma. The clinical or radiologic diagnosis of pneumonia or fluid overload should not be made in the uncontrolled diabetic patient in the absence of unequivocal evidence of infection or congestive heart failure. The development of dyspnea, hypoxemia, rales, or infiltrates in the otherwise routine resuscitation of these patients should lead the clinician to suspect the development of ARDS. Prompt invasive monitoring in these cases is indicated to aid in their management and may help to improve survival. We found calculation of the A-a gradient to be useful in patients with uncontrolled diabetes. Although not necessarily predictive, widened gradients were the earliest detectable abnormality found in all patients who developed ARDS
Next-generation dendritic cells for immunotherapy of acute myeloid leukemia
Authors: Frauke Schnorfeil, Felix Lichtenegger, Christiane Geiger, Thomas Köhnke, Veit Bücklein, Torben Altmann, Beate Wagner, Reinhard Henschler, Iris Bigalke, Gunnar Kvalheim, Wolfgang Hiddemann, Dolores Schendel, Marion Subklewe
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Post-remission therapy of patients with acute myeloid leukemia (AML) is critical for the elimination of minimal residual disease (MRD) and a prerequisite for achieving cure. Cellular immunotherapy is a highly effective treatment option as demonstrated by the low relapse rate after
Patient-Centered Medical Home Implementation and Use of Preventive Services
Authors: Amanda R. Markovitz, Jeffrey A. Alexander, Paula M. Lantz, Michael L. Paustian
Journal: JAMA Internal Medicine (2015)

The patient-centered medical home (PCMH) model of primary care is being implemented in a wide variety of socioeconomic contexts, yet there has been little research on whether its effects differ by context. Clinical preventive service use, including cancer screening, is an important outcome to assess the effectiveness of the PCMH within and across socioeconomic contexts.To determine whether the relationship between the PCMH and cancer screening is conditional on the socioeconomic context in which a primary care physician practice operates.A longitudinal study spanning July 1, 2009, through June 30, 2012, using data from the Blue Cross Blue Shield of Michigan Physician Group Incentive Program was conducted. Michigan nonpediatric primary care physician practices that participated in the Physician Group Incentive Program (5452 practice-years) were included. Sample size and outlier exclusion criteria were applied to each outcome. We examined the interaction between practices' PCMH implementation scores and their socioeconomic context. The implementation of a PCMH was self-reported by the practice's affiliated physician organizations and was measured as a continuous score ranging from 0 to 1. Socioeconomic context was calculated using a market-based approach based on zip code characteristics of the practice's patients and by combining multiple measures using principal components analysis.Breast, cervical, and colorectal cancer screening rates for practices' Blue Cross Blue Shield of Michigan patients.The implementation of a PCMH was associated with higher breast, cervical, and colorectal cancer screening rates across most market socioeconomic contexts. In multivariable models, the PCMH was associated with a higher rate of screening for breast cancer (5.4%; 95% CI, 1.5% to 9.3%), cervical cancer (4.2%; 95% CI, 1.4% to 6.9%), and colorectal cancer (7.0%; 95% CI, 3.6% to 10.5%) in the lowest socioeconomic group but nonsignificant differences in screening for breast cancer (2.6%; 95% CI, -0.1% to 5.3%) and cervical cancer (-0.5%; 95% CI, -2.7% to 1.7%) and a higher rate of colorectal cancer (4.5%; 95% CI, 1.8% to 7.3%) screening in the highest socioeconomic group. Because PCMH implementation was associated with larger increases in screening in lower socioeconomic practice settings, models suggest reduced disparities in screening rates across these contexts. For example, the model-predicted disparity in breast cancer screening rates between the highest and lowest socioeconomic contexts was 6% (77.9% vs 72.2%) among practices with no PCMH implementation and 3% (80.3% vs. 77.0%) among practices with full PCMH implementation.In our study, the PCMH model was associated with improved cancer screening rates across contexts but may be especially relevant for practices in lower socioeconomic areas.
Detecting myocardial ischemia from four bipolar leads reconstructed from the unipoles that are potentially available in implanted devices
Authors: Azad Ghuran, Dan Wichterle, Ian Little, Kamran Baig, Velislav Batchvarov, A.John Camm, Charles Pumphrey, David Ward, Marek Malik
Journal: Journal of the American College of Cardiology (2002)
The gut microbiota and the liver. Pathophysiological and clinical implications
Authors: Eamonn M.M. Quigley, Catherine Stanton, Eileen F. Murphy
Journal: Journal of Hepatology (2012)

The term microbiota is used to describe the complete population of microorganisms that populate a certain location, such as the gut, and is preferred to the term flora as the former incorporates not just bacteria but also archaea, viruses, and other microorganisms, such as protozoa. Though the potential role of the microbiota (through such concepts as "the putrefactive principle associated with faeces" and "intestinal toxins") in the pathogenesis of systemic disorders has been recognized since antiquity, a firm scientific basis for a role for the gut microbiome in liver disease did not emerge until the middle of the last century with the recognition of the relationship between hepatic coma and the absorption of nitrogenous substances from the intestine [1].
HIGHER RESTENOSIS AT THE MAIN AND SIDE BRANCH OSTIUM WAS EXPLAINED BY BOTH INADEQUATE STENT EXPANSION AND INCREASED NEOINTIMAL PROLIFERATION AFTER CORONARY BIFURCATION STENTING: SERIAL INTRAVASCULAR ULTRASOUND STUDY
Authors: Hyeon-Cheol Gwon, Young Bin song, Joo Yong Hahn, Jin Ho Choi, Seung Hyuk Choi, Sang Hoon Lee
Journal: Journal of the American College of Cardiology (2010)
Neurocirculatory Asthenia
Authors: Paul D. White
Journal: New England Journal of Medicine (1964)

ONE of the great causes of disability in World War I was not structural disease and not a simple neurosis or malingering. This condition was called by the British Medical officers the "irritable heart of soldiers," as it had been called by Da Costa, a surgeon in the Northern armies in the American Civil War, and later "effort syndrome." Thomas Lewis's American colleagues who studied this condition in Colchester, England, during World War I changed its name to "neurocirculatory asthenia," a term that has been used ever since.By definition this disease — for it is a disease — is . . .
1022 EVALUATION OF POTENTIAL VIROLOGIC RESISTANCE IN HBV POLYMERASE AMONG SUBJECTS WITH PERSISTENT VIREMIA FOLLOWING UP TO 144 WEEKS OF THERAPY WITH TENOFOVIR DF
Authors: A. Snow-Lampart, B. Chappell, J. Sorbel, K. Borroto-Esoda, M. Miller
Journal: Journal of Hepatology (2010)
Idiopathic carpal tunnel syndrome.
Authors: J B Witcombe
Journal: BMJ (1980)

of dorsal column stimulation from the random variability of the disease, placebo effects, and suggestibility.This can in part be overcome by making multiple observations so that the variance before treatment is defined, which should take care of the disease fluctuations.Placebo and suggestibility effects tend to wear off after a few weeks' therapy and are less of a problem when studying autonomic function.Automated urinary flow studies (for example, by Disa Mictiograph) are probably the single most useful ncn-invasive test by which the effects of dorsal column stimulation can be measured.Finally, it is suggested that anyone embarking on trials of dorsal column stimula- tion should discuss it fully with a qualified medical statistician so that the results can be properly analysed.
Letter: Erythema nodosum and brucellosis.
Authors: G A MacGregor
Journal: BMJ (1976)

between treated and untreated patients in learning behaviour or intellect, and seizure control was significantly improved in the treated group.7A more recent survey of epileptic children in schools showed that those who were receiving phenobarbitone were achieving more educationally and had fewer behaviour problems than others who were not being so treated.8Furthermore, no significant reduction was noted in the Wechsler Intelli- gence Scale for Children when this was administered at least eight years after a con- vulsion with fever to children who had received barbiturates for at least one year before the age of 7 years.9On the other hand, a reduced verbal quotient was significantly related to recurrence of convulsions.9It has been shown that it may not be possible to prevent all recurrences of febrile convulsions by the use of phenobarbitone in apparently "therapeutic" dosage," but significant reduction in the recurrence rate has been achieved in a group of high-risk patients.'2Longer, better-controlled studies must surely be conducted before barbiturates are discarded in favour of less well-tried and possibly more harmful anticonvulsants.
Roger Baron Pickford
Authors: F. Williams
Journal: BMJ (2008)

Roger Baron Pickford (“Rog”) died suddenly from unsuspected idiopathic dilated cardiomyopathy while camping with his brother in his beloved Marloes, Pembrokeshire. Roger had singlehandedly set up a highly regarded adult and paediatric echocardiography service during the early 1980s, and it seemed quite ironic that he should die of an undetected cardiac condition.

Roger was profoundly deaf, …
Shiny happy people?
Authors: D. Spence
Journal: BMJ (2009)

Feeling miserable, I leant out of the window to see the heat haze and smell the pheromones. In the street below couples walked arm in arm, there was a distant crackle of a radio, and men flexed with their tops off chasing a tan—these were unenlightened days. Most of the world phoned in sick, and people pulled old sofas on to the street to drink beer. Medical students, however, always finished university last, and so I was on death row with two …
Ultrastructural Studies of Fibroblasts Transfected with Hepatitis B Virus DNA†
Authors: Naoto Aoki, Michael A. Gerber, Swan N. Thung, Mei-Ling Chen, Judith K. Christman, Peter M. Price, Christos S. Flordellis, George Acs
Journal: Hepatology (1984)

Cultured 3T3 mouse fibroblasts transfected with cloned hepatitis B virus genome and DNA coding for methotrexate-resistant dihydrofolate reductase, produce and secrete significant amounts of hepatitis B surface antigen (HBsAg). Ultrastructural morphometry revealed that fibroblasts transfected with hepatitis B virus DNA contained significantly more lysosomes than did fibroblasts transfected with the gene coding for methotrexate resistance or normal fibroblasts. Although abundant HBsAg was found in the cytoplasm of transfected fibroblasts by immunologic methods, HBsAg particles were not detected by electron microscopy. Immunoelectron microscopy localized HBsAg to the nuclear envelope, rough endoplasmic reticulum, and endoplasmic cisternae. These findings suggest that the transfected cells produce mainly nonparticulate HBsAg or that they have a defect in intracisternal packaging of HBsAg into particles.
788 INTERFERON-α MEDIATED ACTIVATION OF NATURAL KILLER CELLS IS ASSOCIATED WITH EFFICIENT INDUCTION OF APOPTOSIS OF ACTIVATED PRIMARY HUMAN HEPATIC STELLATE CELLS
Authors: A. Glässner, M. Eisenhardt, B. Krämer, C. Körner, T. Sauerbruch, U. Spengler, J. Nattermann
Journal: Journal of Hepatology (2011)
Adverse Occurrences in the Intensive Care Unit-Reply
Authors: Ake Grenvik
Journal: JAMA (1981)

<h3>In Reply.—</h3> We thank Drs Merrill and Boisaubin for their comments about the importance of error prevention in medicine. The diurnal rise in human error, peaking at about 3 AM and 3 PM, which they mention, should be further investigated for its applicability to medicine. Our observation that the number of reported incidents peaked between midnight and 1 AM may have been influenced by the work, staffing, and activity patterns in our intensive care unit. Our number of cases was small, and, except for this one peak, the rest of the time distribution was not significantly different than random. The number of reported incidents may be different than the total number of mishaps that actually occur. Thus, we probably reported only on a preselected "tip of the iceberg." Furthermore, a reported incident depends on the personnel involved to detect and report it. This may be different than errors noted by
Lack of effects of isosorbide-5-mononitrate on hepatic hemodynamics in HBsAg-positive cirrhosis
Authors: Yang-Te Tsai, Fa-Yauh Lee, Han-Chieh Lin, Ting-Tsung Chang, Chii-Shyan Lay, Sun-Sang Wang, Chi-Woon Kong, Shou-Dong Lee, Kwang-Juei Lo
Journal: Hepatology (1989)

We conducted a randomized controlled hemodynamic study to evaluate the effect of placebo and 20 mg isosorbide-5-mononitrate, a long-acting organic nitrate, in 19 patients with HBsAg-positive cirrhosis by the simultaneous measurement of portal venous pressure and wedged hepatic venous pressure. Baseline values for the two groups were similar. One hour after oral administration of 20 mg isosorbide-5-mononitrate in 10 patients, mean arterial pressure, mean pulmonary arterial pressure and pulmonary capillary wedge pressure significantly decreased from 92 +/- 13 (mean +/- S.D.) to 82 +/- 14 mmHg, from 12.9 +/- 4.5 to 9.3 +/- 2.4 mmHg and from 6.9 +/- 3.4 to 4.3 +/- 1.8 mmHg, respectively. However, both portal venous pressure gradient (from 18.1 +/- 3.6 to 17.5 +/- 3.0 mmHg) and hepatic venous pressure gradient (from 17.8 +/- 5.2 to 16.6 +/- 5.3 mmHg) remained unchanged during the study. In six patients who received 20 mg isosorbide-5-mononitrate twice daily for 7 days, hepatic venous pressure gradient remained unaltered as compared to basal and 1-hr values. There was no significant change in cardiac index, heart rate or systemic vascular resistance in either immediate (1-hr) or delayed (7-day) studies. Three patients (30%) developed mild headache or dizziness and two patients (20%) demonstrated systolic hypotension (less than mmHg) during the immediate study. This study shows that isosorbide-5-mononitrate appears to have no effect in treating portal hypertension in patients with HBsAg-positive cirrhosis. In addition, the isosorbide-5-mononitrate may affect the systemic circulation more than the portal circulation.
The case of the missing CVs: Multi-joint primitives
Authors: Simon Giszter
Journal: Behavioral and Brain Sciences (1995)

Abstract The search for simplifying principles in motor control motivates the target article. One method that the CNS uses to simplify the task of controlling a limb's mechanical properties is absent from the article. Evidence from multi-joint, force-field measurements and from kinematics that points to the existence of multi-joint primitives as control variables is discussed.
Postmenopausal Hormone Replacement Therapy
Authors: Arthur B. Chausmer
Journal: Annals of Internal Medicine (2003)

Letters15 April 2003Postmenopausal Hormone Replacement TherapyArthur B. Chausmer, MD, PhDArthur B. Chausmer, MD, PhDDorn Veterans Affairs Medical Center; University of South Carolina; Columbia, SC 29209 (Chausmer)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-8-200304150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Humphrey and colleagues (1) somewhat blindly accept HRT and treatment with Premarin (Wyeth, Madison, New Jersey) as being interchangeable. They clearly are not, and the differences are sufficient to cause questioning of all of Humphrey and colleagues' data. Premarin is conjugated equine estrogen. The estrogenic compounds are not native to humans. Some are more active in estrogenic assays, and some are less active. Actions on other pathways are not well known and may account for some of the events seen with Premarin. Drawing conclusions and basing therapeutic decisions on data from Premarin may have been acceptable when ...Reference1. Humphrey LL, Chan BK, Sox HC. Postmenopausal hormone replacement therapy and the primary prevention of cardiovascular disease. Ann Intern Med. 2002;137:273-84. [PMID: 12186518] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Dorn Veterans Affairs Medical Center; University of South Carolina; Columbia, SC 29209 (Chausmer) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPostmenopausal Hormone Replacement Therapy and the Primary Prevention of Cardiovascular Disease Linda L. Humphrey , Benjamin K.S. Chan , and Harold C. Sox Postmenopausal Hormone Replacement Therapy Linda L. Humphrey , Benjamin K.S. Chan , and Harold C. Sox Postmenopausal Hormone Replacement Therapy Steven J. Meyerson Postmenopausal Hormone Replacement Therapy and Cardiovascular Disease Arnold B. Ritterband and Israeli A. Jaffe Metrics Cited ByPostmenopausal hormone therapy and breast cancer: a systematic review and meta-analysisPostmenopausal Hormone Replacement Therapy and Cardiovascular DiseaseArnold B. Ritterband, MD and Israeli A. Jaffe, MD 15 April 2003Volume 138, Issue 8Page: 687-688KeywordsAdverse eventsBloodC-reactive proteinsEstradiolEstrogen replacement therapyEstrogensLiverStatistical dataThyroid ePublished: 15 April 2003 Issue Published: 15 April 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
What should we be doing?
Authors: S A P. Chubb, Z. Khatami
Journal: BMJ (2010)

Like general practitioners responding to the clinical review on the diagnosis and management of vitamin D deficiency,1 2 we would appreciate guidance on whether a vitamin D assay is required in all patients considered at risk of deficiency, or only in selected cases.

Our laboratory received over 3900 requests for 25-OH vitamin …
Enhanced delivery of T cells to tumor after chemotherapy using membrane-anchored, apoptosis-targeted peptide
Authors: Xiaofeng He, Napolean Bonaparte, Soyoun Kim, Bodhraj Acharya, Ji-Young Lee, Lianhua Chi, Hyoung-Joo Lee, Young-Ki Paik, Pyong-Gon Moon, Moon-Chang Baek, Eun-Kyu Lee, Jong-Ho Kim, In-San Kim, Byung-Heon Lee
Journal: Journal of Controlled Release (2012)
NUTRITION IN SCHOOLCHILDREN
Authors: TALIAFERRO CLARK
Journal: JAMA (1922)

It is not the purpose of this paper to discuss nutrition from the standpoint of calory requirement, relative protein nutritive value, vitamin content or metabolic processes. Our inquiry is directed more particularly to certain phases of nutrition work now being widely attempted in the schools, and which may affect, for better or for worse, 20 per cent. of the total population, representing the approximate school enrolment of a given community. For untold generations, men and women have been born, "had their being," and died at a ripe old age, without thought of the state of nutrition or the character of the food ingested other than that inspired by a catholic appetite. But, within the last few years, all has changed, and the popular conception of malnutrition is—shall I say?—so inaccurate that the veriest tyro in public health work, after placing a child on a scale and noting comparative results, gravely