Gastrointestinal Polyposis Associated with Alopecia, Pigmentation, and Atrophy of the Fingernails and Toenails
Authors: M. M. JOHNSTON
Journal: Annals of Internal Medicine (1962)

Case Reports1 June 1962Gastrointestinal Polyposis Associated with Alopecia, Pigmentation, and Atrophy of the Fingernails and ToenailsM. M. JOHNSTON, M.D., J. W. VOSBURGH, M.D., A. T. WIENS, M.D., G. C. WALSH, M.D., C.M., F.R.C.P. (C), F.A.C.P.M. M. JOHNSTON, M.D., J. W. VOSBURGH, M.D., A. T. WIENS, M.D., G. C. WALSH, M.D., C.M., F.R.C.P. (C), F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-6-935 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecently we have encountered a patient with alopecia, pigmentation of the hands and arms, and atrophy of the fingernails and toenails associated with gastrointestinal polyposis. A review of the literature has revealed that this case is not unique, Cronkhite and Canada (1) in 1955 having described the syndrome in 2 patients.This paper presents the case history and the results of certain studies in this patient, then discusses the syndrome with particular reference to the pathophysiological aspects; finally this condition is compared with other intestinal disorders associated with changes in ectodermal structures.CASE REPORTThe patient was a 51-year-old Canadian-born...References1. CRONKHITECANADA LWWJ: Generalized gastrointestinal polyposis; an unusual syndrome of polyposis, pigmentation, alopecia, and onychotrophia. New Engl. J. Med. 252: 1011, 1955. CrossrefMedlineGoogle Scholar2. STEINFELDDAVIDSONGORDONGREENE JLJDRSFE: The mechanism of hypoproteinemia in patients with regional enteritis and ulcerative colitis. Amer. J. Med. 29: 405, 1960. CrossrefMedlineGoogle Scholar3. GROSSEMBREEBALLYSHIPPTHORN PALJPJCGW: Hypoalbuminemia due to hypercatabolism, serum protein exudation into the gastrointestinal tract, increased capillary permeability and hypoanabolism. Amer. J. Med. 29: 386, 1960. CrossrefMedlineGoogle Scholar4. GORDON JS: Exudative enteropathy. Lancet 1: 325, 1959. CrossrefMedlineGoogle Scholar5. SCHWARTZJARNUM MS: Gastrointestinal protein loss in idiopathic (hypercatabolic) hypoproteinemia. Lancet 1: 327, 1959. CrossrefMedlineGoogle Scholar6. ANDRELL O: Gastric polypi and alopecia areata. Svensk. Lakartidn. 56: 2779, 1959. MedlineGoogle Scholar7. RAVITCH MM: Polypoid adenomatosis of the entire gastrointestinal tract. Ann. Surg. 128: 283, 1948. CrossrefMedlineGoogle Scholar8. JEGHERSMCKUSICKKATZ HVAKH: Generalized intestinal polyposis and melanin spots of the oral mucosa, lips, and digits. New Engl. J. Med. 241: 993, 1949. CrossrefMedlineGoogle Scholar9. DORMANDY TL: Small intestinal polyposis. Proc. Roy. Soc. 52: 22, 1959. MedlineGoogle Scholar10. BARTHOLOMEWDAHLINWAUGH LGDCJM: Intestinal polyposis associated with mucocutaneous melanin pigmentation (Peutz-Jeghers syndrome). Gastroenterology 32: 434, 1957. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Vancouver,This paper was presented at the regional meeting of the American College of Physicians in Seattle, Washington, October 28-29, 1960.Requests for reprints should be addressed to George C. Walsh, M.D., 5780 Cambie Street, Suite 370, Vancouver 15, British Columbia, Canada. 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