Anticardiolipin Antibodies and the Lupus Anticoagulant
Authors: MICHAEL D. LOCKSHIN
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 September 1987Anticardiolipin Antibodies and the Lupus AnticoagulantMICHAEL D. LOCKSHIN, M.D., AZZUDIN E. GHARAVI, M.D.MICHAEL D. LOCKSHIN, M.D.Search for more papers by this author, AZZUDIN E. GHARAVI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-2-431 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Petri and colleagues (1) have used the antiphospholipid antibody test inappropriately. They have committed the etymologic and intellectual solecisms of predicting past events with point prevalence assays. The logical conclusion of their article is that antiphospholipid antibody does not validate remote events, a conclusion that trivializes not only this but any laboratory assay.It is particularly disturbing that Petri and colleagues do not define or validate the clinical events they report. For instance, they do not distinguish early spontaneous abortion from the very different midpregnancy fetal death (2). They do not indicate the number of pregnancies at...References1. PETRI M, RHEINSCHMIDT M, WHITING-O'KEEFE Q, HELLMANN D, and CORASH L. The frequency of lupus anticoagulant in systemic lupus erythematosus: a study of sixty consecutive patients by activated partial thromboplastin time, Russell viper venom time, and anticardiolipin antibody level. Ann Intern Med. 1987;107:524-31. LinkGoogle Scholar2. COWCHOCK S, SMITH J, and GOCIAL B. Antibodies to phospholipids and nuclear antigens in patients with repeated abortions. Am J Obstet Gynecol. 1986;155:1002-10. CrossrefMedlineGoogle Scholar3. LOCKSHIN M, DRUZIN M, and GOEI S. Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with systemic lupus erythematosus. N Engl J Med. 1985;313:152-6. CrossrefMedlineGoogle Scholar4. LOCKSHIN M, QAMAR T, DRUZIN M, and GOEI S. Antibody to cardiolipin, lupus anticoagulant and fetal death. J Rheumatol. 1987;14. (In press). MedlineGoogle Scholar5. HARRIS E, CHAN J, ASHERSON R, ABER V, GHARAVI A, and HUGHES G. Thrombosis, recurrent fetal loss, and thrombocytopenia: predictive value of the anticardiolipin antibody test. Arch Intern Med. 1986;146:2153-6. CrossrefMedlineGoogle Scholar6. LOCKSHIN M. Anticardiolipin antibody. Arthritis Rheum. 1987;30. (In press). CrossrefMedlineGoogle Scholar7. ASHERSON R, CHAN J, HARRIS E, GHARAVI A, and HUGHES G. Anticardiolipin antibody, recurrent thrombosis, and warfarin withdrawal. Ann Rheum Dis. 1985;44:823-5. CrossrefMedlineGoogle Scholar1. PETRI M, RHEINSCHMIDT M, WHITING-O'KEEFE Q, HELLMANN D, and CORASH L. The frequency of lupus anticoagulant in systemic lupus erythematosus: a study of sixty consecutive patients by activated partial thromboplastin time, Russell viper venom time, and anticardiolipin antibody level. Ann Intern Med. 1987;106:524-31. LinkGoogle Scholar2. HARRIS E, CHAN J, ASHERSON R, ABER V, GHARAVI A, and HUGHES G. Thrombosis, recurrent fetal loss, and thrombocytopenia: predictive value of the anticardiolipin antibody test. Arch Intern Med. 1986;146:2153-6. CrossrefMedlineGoogle Scholar3. DERKSEN R, BOUMA B, and KATER L. The striking association between lupus anticoagulant and fetal loss in systemic lupus erythematosus patients [Letter]. Arthritis Rheum. 1986;29:695-6. CrossrefMedlineGoogle Scholar4. LOCKSHIN M, DRUZIN M, and GOEI S. Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with systemic lupus erythematosus. N Engl J Med. 1985;313:152-6. CrossrefMedlineGoogle Scholar5. DERUE G, ENGLERT H, and HARRIS E. Fetal loss in systemic lupus: association with anticardiolipin antibodies. J Obstet Gynaecol. 1985;5:207-9. CrossrefGoogle Scholar1. PETRI M, RHEINSCHMIDT M, WHITING-O'KEEFE Q, and HELLMANN D. The frequency of lupus anticoagulant in systemic lupus erythematosus: a study of sixty consecutive patients by activated partial thromboplastin time, Russell viper venom time, and anticardiolipin antibody level. Ann Intern Med. 1987;106:524-31. LinkGoogle Scholar2. HARRIS E, CHAN J, ASHERSON R, ABER V, GHARAVI A, and HUGHES G. Thrombosis, recurrent fetal loss, thrombocytopenia: predictive value of the anticardiolipin test. Arch Intern Med. 1986;146:2153-6. CrossrefMedlineGoogle Scholar3. LOCKSHIN M, QAMAR T, DRUZIN M, and GOEI S. Antibody to cardiolipin, lupus anticoagulant and fetal death. J Rheumatol. 1987;14:259-62. MedlineGoogle Scholar4. HARRIS E, GHARAVI A, PATEL S, and HUGHES G. Evaluation of the anticardiolipin antibody test: report of an international workshop held 4 April 1986. Clin Exp Immunol. 1987;68:215-22. MedlineGoogle Scholar5. GASTINEAU D, KAZMIER F, NICHOLS W, and BOWIE E. Lupus anticoagulant: an analysis of the clinical and laboratory features of 219 cases. Am J Hematol. 1985;19:265-95. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MICHAEL D. LOCKSHIN, M.D.; AZZUDIN E. GHARAVI, M.D.Affiliations: The Hospital for Special Surgery New York, NY 10021 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFalse-positive maternal serum screening in systemic lupus erythematosis: a case reportShould anticardiolipin tests be performed in otherwise healthy pregnant women?Should anticardiolipin tests be performed in otherwise healthy pregnant women?Maternal autoantibodies and pregnancy—I: The antiphospholipid antibody syndrome 1 September 1987Volume 107, Issue 3Page: 431-433KeywordsAntibodiesAnticoagulantsFetal deathMiscarriagePregnancyResearch laboratories ePublished: 1 December 2008 Issue Published: 1 September 1987 PDF downloadLoading ...