tbuckley/cabot-search huggingface dataset:
Frequency of Hemolytic Transfusion Reactions
Authors: P.H. Pinkerton
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 May 1989Frequency of Hemolytic Transfusion ReactionsP.H. Pinkerton, MDP.H. Pinkerton, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-10-847_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: I am surprised, indeed astonished, that the opening statement of the article by Schorn and Knospe (1) should have passed expert editorial scrutiny and proofreading. It contains two erroneous statements which would leave the relatively inexpert reader with two totally misleading impressions.First, delayed hemolytic transfusion reactions are quite common and any busy hospital blood bank may expect to see several each year. Second, although such reactions are indeed caused by the transfusion of incompatible blood, this does not result from clerical error, but is a consequence of the fact that routine blood bank techniques for the...Reference1. Schorn T and Knospe W. Fatal delayed hemolytic transfusion reaction without previous blood transfusion. Ann Intern Med. 1989;110:241-2. LinkGoogle Scholar1. Schorn T and Knospe W. Fatal delayed hemolytic transfusion reaction without previous blood transfusion. Ann Intern Med. 1989;110:241-2. LinkGoogle Scholar2. Myhre B. Fatalities from blood transfusions. JAMA. 1980;244:1333-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: P.H. Pinkerton, MDAffiliations: Sunnybrook Hospital Toronto, Ontario PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLes accidents immuno-hémolytiques transfusionnels IV. Analyse, risques et prévention 15 May 1989Volume 110, Issue 10Page: 847-847KeywordsBlood banksBlood transfusion ePublished: 1 December 2008 Issue Published: 15 May 1989 PDF downloadLoading ...
462 Influence of interleukin 12B gene (IL 12B) polymorphism in spontaneous or treatment-induced recovery from hepatitis C (HCV) infection
Authors: T. Mueller, A. Mas-Marques, M. Wiese, J. Halangk, H. Witt, U. Goebel, B. Wiedenmann, E. Schreier, T. Berg
Journal: Journal of Hepatology (2004)
Physician and Coding Errors in Patient Records
Authors: Susan S. Lloyd, J. Peter Rissing
Journal: JAMA (1985)

The Veterans Administration's discharge abstract system was studied to identify error frequency, source, and effect in five Veterans Administration hospitals. We reviewed 1,829 medical records from 21 services for concordance with the abstract; sampling provided 95% confidence for each service. Of these records, 1,499 (82%) differed from the abstract in at least one item. Of 20,260 items, 4,360 (22%) were incorrect, with three error sources: physician (62%), coding (35%), and keypunch (3%). We projected 2.14 physician and 0.81 coding errors in the average abstract. Eighty-nine percent of projected physician errors were failures to report a procedure or diagnosis. Coding was subjective and errors were synergistic with physician errors. We projected that correction of errors would change 19% of the records for diagnosis-related group purposes and substantially increase future resource allocation. This effect varied considerably by service.
Acquired Immunodeficiency Syndrome with Progressive Multifocal Leukoencephalopathy and Monoclonal B-Cell Proliferation
Authors: JOHN L. HO
Journal: Annals of Internal Medicine (1984)

A 34-year-old man who used intravenous drugs developed the acquired immunodeficiency syndrome with lymphadenopathy, Mycobacterium tuberculosis pneumonia, and progressive multifocal leukoencephalopathy. Early biopsy specimens of the lymph node showed hyperplasia without evidence of lymphoma. Later, immunologic analysis of peripheral blood lymphocytes showed inversion of the helper/suppressor T-lymphocyte ratio and persistent monoclonal B-cell proliferation without clinically overt lymphoma. The clinical course of this patient suggests that abnormal immune responses seen in the setting of the acquired immunodeficiency syndrome may evolve into lymphoproliferative disorders detectable by peripheral blood lymphocyte analysis.
Inventing the NIH: Federal Biomedical Research Policy, 1887-1937
Authors: James G. Burrow
Journal: JAMA (1987)

This impressive volume traces the origin of the federal government's support of continuous biomedical research to the work of the Laboratory of Hygiene, which the Marine Hospital Service established at its location in the city of New York in 1887. It carries federal research policies and agencies through the early work of the first National Institute of Health, established in 1930, and derives its title from an observation made in 1980 by a scientist, Robert M. Bock, that if the National Institutes of Health did not exist, they would have to be invented. Even before the century ended, the modest Hygienic Laboratory, as it was soon called, had taken on significant responsibilities. It conducted the first bacteriologic diagnosis of cholera in the Western Hemisphere and explored the origins of yellow fever, pneumonia, and anthrax. By the end of the 1890s, it had given itself over to extensive investigation of some
THE INVARIABLE BLOOD-STAIN
Authors: B. G. R. WILLIAMS
Journal: JAMA (1913)

For years I have used in my laboratory a method for the staining of blood-films which has proved so satisfactory from all points of view as to have earned the term "invariable." The idea is not original with me, but is based on two well-known principles, combined, modified and finally perfected. First of all, single films are best fixed by burning in absolute alcohol; a proper mixing of eosin with Ehrlich's acid hematoxylin gives an excellent stain, one which proved its worth before the panoptic formulas became so popular. This method is especially suited to the needs of the general practitioner, the man who desires invariable results and who cannot become proficient in technic. Certain men, who do considerable blood work, are now using the "invariable" almost routinely. Several of these have prevailed on me to publish the formula and technic; and this will perhaps justify the addition of another
Collective Stress Syndrome
Authors: Jonathan Mann
Journal: JAMA (1979)

<h3>To the Editor.—</h3> In the last few years, we have observed among schoolchildren several outbreaks of acute illness that probably represent instances of mass hysteria. In each situation, we have been impressed with the entirely negative and distressing implications of the term "hysteria." For the persons involved (and their parents), the term "mass hysteria" is perceived as an affront to personal integrity. For medical personnel and the general public, unfortunate confusion may arise between episodes of mass hysteria and the psychiatric diagnosis of hysteria. We therefore propose that the term "collective stress syndrome" be adopted to describe outbreaks of illness formerly referred to as mass hysteria. The use of collective stress syndrome may result in a reduction of defensiveness and anger, thereby facilitating a more reasoned analysis of events and predisposing causes. We believe that enhanced communication will result when the stigma of hysteria is replaced by the generally well-accepted
Melanoma prognosis in Europe: far from equal
Authors: A.M. Forsea, V. del Marmol, A. Stratigos, A.C. Geller
Journal: British Journal of Dermatology (2014)

Comprehensive, population-based analysis of melanoma survival throughout Europe is hindered by the uneven coverage and quality of European cancer registries, and by logistical and financial shortcomings. Mortality-to-incidence ratios (MIRs) have been used as a proxy for estimating survival for multiple cancers and to model melanoma prognosis, higher MIR values reflecting poorer prognosis. Updated and improved pan-European estimates of mortality and incidence rates for melanoma have become available through the International Agency for Research of Cancer project Globocan 2008, showing marked differences among European countries.To analyse MIRs for melanoma across Europe and their relationship with national health expenditures, aiming to identify countries and regions with disproportionately poor prognosis.Estimated age-standardized rates of melanoma incidence and mortality provided by Globocan 2008 were used to calculate the MIR for each European country and region. Total health expenditures per capita in European countries for 2008 were provided by the World Health Organization/Global Health Observatory. The potential correlation between MIR and total health expenditure per capita was analysed through Pearson's correlation.Mortality-to-incidence ratios for melanoma ranged between 0·09 in Switzerland and 0·44 in Latvia. The regional average MIR was the highest in Central and Eastern Europe at 0·35; the lowest was in Western Europe, at 0·13. We found a strong inverse correlation between the individual nation's total health expenditure per capita and the calculated melanoma MIR (r = -0·76, P < 0·05).While further improvement of melanoma registration is necessary, our findings reveal sharp disparities in the prognosis of melanoma across the Continent, correlated with significant differences in health care expenditures.
Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract
Authors: Lei Bu, Yiping Jin, Yuefeng Shi, Renyuan Chu, Airong Ban, Hans Eiberg, Lisa Andres, Haisong Jiang, Guangyong Zheng, Meiqian Qian, Bin Cui, Yu Xia, Jing Liu, Landian Hu, Guoping Zhao, Michael R. Hayden, Xiangyin Kong
Journal: Nature Genetics (2002)
A third of people in UK with HIV don't know they are infected
Authors: Andrew Cole
Journal: BMJ (2007)

The drug industry is "burying its head in the sand" when dealing with health in developing countries and denying poorer people access to life saving drugs, a report claims this week.A critical report by the international agency Oxfam says that the drug industry is refusing to change the way it does business in poor countries, despite promising that it would, and is undermining its own future.Oxfam's report looks at the world's top 12 drug companies, including their drug pricing policies, their record in developing drugs that are relevant to health care in poor countries, and their stance on protecting intellectual property rights.The report says that the industry shows various shortcomings, including:• Failure to implement a systematic and transparent tiered pricing policy that is based on people's ability to pay • Continuing to neglect research and development concerning diseases that affect developing countries, and • Inflexibility in protecting intellectual property, which includes challenging poor countries in court to stop them using legal safeguards to protect public health.Oxfam interviewed 12 companies in preparing the report: Abbott, AstraZeneca, Bristol-Myers Squibb, GlaxoSmithKline, Eli Lilly, Johnson & Johnson, Merck, Novartis, Pfizer, Roche, Sanofi-Aventis, and Wyeth
A Self-Administered Version of a Brief Measure of Suffering: First Aspects of Validity
Authors: Hans-Jürgen Rumpf, Werner Löntz, Susanne Uesseler
Journal: Psychotherapy and Psychosomatics (2003)

Measuring the impact of illness is important for several reasons. Recently, a new instrument was introduced using a pictorial approach in measuring the perception of suffering caused by illness: the Pictorial Representation of Illness Measure (PRISM). The aim of the present study was to introduce a self-administered version of PRISM and to provide some first data on its validity.A postal survey was conducted in subjects with the chronic depigmentation disorder vitiligo. Participants were members of the German vitiligo association. The response rate was 60.6%. Data of 333 respondents completing the PRISM were used for analysis. Besides illness-related measures, psychological variables were assessed with the following instruments: Satisfaction with Life Scale (SWLS), five-item version of the Mental Health Inventory, adaptation of the Skindex-29, a quality-of-life measure for skin diseases.Only 2.9% did not fill in the PRISM. Self-illness separation correlated as predicted with some illness-related variables. The distance was significantly larger in subjects whose depigmentation was no longer spreading. Significant correlations were also found with mental health (0.50), satisfaction with life (-0.28), perceived impairment of outward appearance (-0.65), and the Skindex subscales 'emotions' (-0.66) and 'functioning' (-0.67).Data suggest that PRISM can be self-administered. Measures of convergent validity confirm the usefulness of the new measure.
Increased prevalence of lung, breast, and pancreatic cancers in addition to melanoma risk in families bearing the cyclin-dependent kinase inhibitor 2A mutation: Implications for genetic counseling
Authors: Miriam Potrony, Joan Anton Puig-Butillé, Paula Aguilera, Celia Badenas, Cristina Carrera, Josep Malvehy, Susana Puig
Journal: Journal of the American Academy of Dermatology (2014)
Assessment of mitral regurgitation by biplane transesophageal color Doppler flow mapping.
Authors: K Yoshida, J Yoshikawa, Y Yamaura, T Hozumi, T Akasaka, T Fukaya
Journal: Circulation (1990)

To test the role of recently developed biplane transesophageal color Doppler echocardiography in the assessment of severity of mitral regurgitation, we examined 51 patients undergoing cardiac catheterization and left ventriculography. Transesophageal color Doppler flow imaging detected mitral regurgitation in all 32 patients proved to have this lesion. In 10 of 16 patients without mitral regurgitation by angiography, mitral regurgitation signals were detected by transesophageal color Doppler flow imaging. Thus, the sensitivity and specificity of transesophageal color Doppler echocardiography for the detection of mitral regurgitation were 100% and 38%, respectively. There was some correlation between the regurgitant jet area from the longitudinal plane and angiographic grading. An improved angiographic correlation was achieved with the regurgitant jet area from the transverse plane. The best correlation with angiography was obtained when the maximum regurgitant jet area from two planes (the greater of the two measurements, each from a different plane) was considered. There was a significant difference in the maximum regurgitant jet area between none and mild (p less than 0.01), mild and moderate (p less than 0.001), and moderate and severe (p less than 0.01) mitral regurgitation. The maximum regurgitant jet area of less than 1.5 cm2 predicted the angiographic grading as none with a sensitivity and specificity of 88% and 94%, respectively. The maximum regurgitant jet of between 1.5 and 4 cm2 predicted the angiographic grading as mild with a sensitivity and specificity of 82% and 95%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Indomethacin for Refractory Infantile Eosinophilic Pustular Folliculitis
Authors: Ellen Toyonaga, Riichiro Abe, Reine Moriuchi, Kei Ito, Yukiko Abe, Hiroshi Shimizu
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Safety and immunogenicity of hepatitis A vaccine in patients with chronic liver disease
Authors: Emmet B. Keeffe, Sten Iwarson, Brian J. McMahon, Karen L. Lindsay, Raymond S. Koff, Michael Manns, Renate Baumgarten, Manfred Wiese, Marc Fourneau, Assad Safary, Ralf Clemens, David S. Krause
Journal: Hepatology (1998)

Acute hepatitis A superimposed on chronic liver disease (CLD) has been associated with severe or fulminant hepatitis. An open, multicenter study was performed to compare the safety and immunogenicity of an inactivated hepatitis A vaccine in patients with CLD with that in healthy subjects. A secondary objective was to compare the safety of the hepatitis A vaccine with that of a commercial hepatitis B vaccine in subjects with chronic hepatitis C. A total of 475 subjects over the age of 18 years were enrolled into 1 of 5 groups according to history, serological data, and previous diagnosis. Patients in groups 1 (healthy adults), 2 (chronic hepatitis B), 3 (chronic hepatitis C), and 5 (other CLD not caused by viral hepatitis) were vaccinated with two doses of inactivated hepatitis A vaccine, 6 months apart. Patients in group 4 (chronic hepatitis C) received 3 doses of a recombinant hepatitis B vaccine, according to a 0-, 1-, and 6-month schedule. Local injection-site symptoms were the most common reactions reported following vaccination in all groups (35.5% of all doses), with the hepatitis B vaccine eliciting fewer injection-site symptoms than the hepatitis A vaccine (19.8% compared with 37.5%). Although a higher percentage of healthy subjects (93%) seroconverted after a single dose of the hepatitis A vaccine than did subjects with chronic hepatitis C (73.7%) or CLD of nonviral etiologies (83.1%), more than 94% of all vaccinees were seropositive for anti-HAV after the complete vaccination course. At each time point, a lower geometric mean concentration of anti-HAV was observed for each group of CLD patients compared with the healthy control subjects. In conclusion, hepatitis A vaccine was well tolerated and induced a satisfactory immune response in patients with chronic hepatitis B, chronic hepatitis C, and miscellaneous CLD.
Gold-Testing in Gold Treatment of Chronic Polyarthritis: Results of Continued Experiments
Authors: T. Svanberg
Journal: Annals of the Rheumatic Diseases (1952)

The sodium thiosulphate solutions, sterilized by a specific procedure, were placed at our disposal by courtesy of the firm of A. B. Astra. March7+ (+) March 16: discharge.Soon afterwards stomatitis and urticaria developed and persisted several weeks.
MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9
Authors: Laure Gilles, Dominique Bluteau, Siham Boukour, Yunhua Chang, Yanyan Zhang, Thomas Robert, Philippe Dessen, Najet Debili, Olivier A. Bernard, William Vainchenker, Hana Raslova
Journal: Blood (2009)
Increased cellularity and expression of adhesion molecules in muscle biopsy specimens from patients with rheumatoid arthritis with clinical suspicion of vasculitis, but negative routine histology
Authors: P. C Verschueren
Journal: Annals of the Rheumatic Diseases (2000)

<h3>OBJECTIVE</h3> Histological analysis of random quadriceps muscle biopsy specimens can be used to detect vasculitis in patients with rheumatoid arthritis (RA). This study aimed at determining the immunohistological features in patients with clinical suspicion of rheumatoid vasculitis, but without a transmural infiltrate or fibrinoid necrosis of the vessel wall on routine histology. <h3>METHODS</h3> Three groups of patients with RA were studied: (<i>a</i>) without clinical signs of vasculitis (n=6); (<i>b</i>) with recent onset of extra-articular features and a clinical suspicion of vasculitis but normal routine histology (n=11); and (<i>c</i>) with recent onset of extra-articular features and vasculitis, histologically proved either in muscle or other biopsy specimens (n=14). A control group of patients with osteoarthritis was also included (n=5). Frozen sections from quadriceps muscle biopsy specimens were analysed with monoclonal antibodies to detect CD3, CD4, CD8, CD68, ICAM-1, VCAM-1, and HLA-DR. The slides were evaluated using a semiquantitative scoring system (0–4). <h3>RESULTS</h3> The mean scores gradually increased from group 1 to 3, leading to significant differences between groups 1 and 2, but not between groups 2 and 3 for most markers (p&lt; 0.05). Thus the pathological changes were similar for the two groups with clinical signs of vasculitis, even when the conventional histological evaluation was negative. Higher immunohistological scores were associated with perivascular infiltrates on routine histology. <h3>CONCLUSION</h3> The pathophysiological events leading to vasculitis are reflected by the changes in the quadriceps muscle biopsy specimens. The data indicate that the sensitivity of examination of muscle biopsy specimens for the diagnosis of rheumatoid vasculitis can be increased by the use of new criteria.
THE TREATMENT OF CHRONIC DISCOID LUPUS ERYTHEMATOSUS WITH A COMBINATION OE ANTIMALARIAL AND CORTKH)STEROID DRUGS.
Authors: SUZANNE ALEXANDER, M. A. COWAN.
Journal: British Journal of Dermatology (1961)

Journal Article THE TREATMENT OF CHRONIC DISCOID LUPUS ERYTHEMATOSUS WITH A COMBINATION OE ANTIMALARIAL AND CORTKH)STEROID DRUGS. Get access SUZANNE ALEXANDER, SUZANNE ALEXANDER Department of Dermatology, The Radcliffe Infirmary, Oxford Search for other works by this author on: Oxford Academic Google Scholar M. A. COWAN. M. A. COWAN. Department of Dermatology, The Radcliffe Infirmary, Oxford Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 73, Issue 10, 1 October 1961, Pages 359–361, https://doi.org/10.1111/j.1365-2133.1961.tb14396.x Published: 01 October 1961
Macroregenerative nodules in a series of adult cirrhotic liver explants: Issues of classification and nomenclature
Authors: Prodromos Hytiroglou, Neil D. Theise, Myron Schwartz, Eytan Mor, Charles Miller, Swan N. Thung
Journal: Hepatology (1995)

Macroregenerative nodules (MRNs), probably representing a pathway for human hepatocarcinogenesis, are generally classified into type I MRNs (or ordinary adenomatous hyperplasia) and type II MRNs (or atypical adenomatous hyperplasia), on the basis of imprecise definitions of cytological and architectural atypia. It is currently believed that type II MRNs are probably true precursors of hepatocellular carcinoma (HCC), whereas type I lesions may simply represent large regenerative nodules. A series of 155 consecutive adult cirrhotic liver explants were examined for evidence of MRNs, HCC, and liver cell dysplasia (LCD) of large and small cell types, and their appearance, in terms of proposed classification schemes, was reviewed. There was evidence indicating that the presence of either type of MRN was associated with an increased incidence of HCC (all MRNs, P < .00019; type I MRNs, P < .067; type II MRNs, P < .012) compared with cirrhotic livers without MRNs. A subset of younger patients with a large (uncountable) number of MRNs in their livers, who did not show any increased incidence of carcinoma, was identified. Excluding these cases from statistical analysis, all associations were strengthened, implying either that malignant progression had not had time to occur in this younger population or that these nodules were simply large regenerative nodules without malignant potential. MRNs from these livers were histologically indistinguishable from MRNs occurring in more limited numbers, although atypical changes other than large cell type LCD were less frequent. No independent association between LCD of large cell type and HCC was found in the entire series.(ABSTRACT TRUNCATED AT 250 WORDS)