tbuckley/cabot-search huggingface dataset:
The scam of integrative medicine
Authors: Margaret McCartney
Journal: BMJ (2011)

<h3>Abstract</h3> Agrobacterium–mediated transformation is a cost-effective and convenient way to introduce foreign genetic elements to plants. However, only limited protocols successfully generates transgenic plants with fielder, a spring wheat variety. Wheat transformation method with higher efficiency and without genotype restriction is heavily demanded. Here, a heat-shock protocol, independent of Japan Tobacco had been established. Transgenic plants can be obtained from immature embryo within only 60 days by this protocol. Morphogenic regulators Baby boom and Wuschel (BBM-WUS) was proved to promote transformation efficiency for five to six times in wheat when co-infiltrated with agrobacterium containing target construct. Notably, half of the transformants are BBM-WUS free and moreover, the BBM-WUS containing plants could be picked by florescent marker that was co-expressed with BBM-WUS. In conclusion, we managed to establish a new wheat transformation protocol with shorter duration than published protocol.
False Positive High Probability V/Q Scan Due to Malignant Obstruction of Both Pulmonary Vein and Artery
Authors: Gad Abikhzer, Khashayar Rafat Zand, Jerry Stern, Jerome Laufer
Journal: Clinical Nuclear Medicine (2009)

A 64-year-old woman with known extensive metastatic breast cancer had a V/Q scan for suspicion of pulmonary embolism. The scan was interpreted as high probability. Due to the discordant clinical status and significant presumed clot burden, the patient underwent a pulmonary CT angiogram (CTA). No arterial embolus was seen and the perfusion defects were found to be caused by malignant obstruction of the left lower lobe pulmonary vein and right pulmonary artery. This high probability ventilation and perfusion (V/Q) scan was therefore a false positive scan for the detection of pulmonary embolus.
Personal View Accident and emergency attendances: a barometer of fear
Authors: S J McGovern
Journal: BMJ (1994)

The upsurge in sectarian violence in Northern Ireland has led to much unnecessary grief and suffering; politicians fail to find words to describe the almost daily atrocities. The theatre of murder has become a fishmonger's, a public house, a farmyard. Ordinary people doing ordinary things are dying in an extraordinary way. Accident and emergency departments in Belfast are no strangers to the victims of terrorist crime but the intensity of this latest wave is of a magnitude not seen for almost 20 years. All accident and emergency units have well worked major incident plans which all too often recently have become reality.

In many Belfast hospitals there are bereavement groups of nurses and doctors who visit the relatives of those who have died in the accident and emergency department. These visits, …
Circulating catecholamines and metabolic effects of captopril in NIDDM patients
Authors: Giancarlo De Mattia, Claudio Ferri, Oriana Laurenti, Maria Cassone-Faldetta, Alfonso Piccoli, Anna Santucci
Journal: Diabetes Care (1996)

OBJECTIVE To evaluate the effects of captopril on circulating catecholamine levels in NIDDM patients and the possible relationship between captopril-related changes in circulating catecholamine levels and insulin sensitivity. RESEARCH DESIGN AND METHODS Fourteen nonobese normotensive NIDDM men (aged 44.5 ± 5.1 years) underwent a 2-h euglycemic-hyperinsulinemic clamp (40 mU·m−2 · min−1). Baseline evaluation of insulin sensitivity was followed by the random assignment of each patient to either captopril or placebo treatment, according to a crossover double-blind design. Euglycemic-hyperinsulinemic clamp studies were then repeated for all patients after both placebo and captopril treatments. Plasma norepinephrine (NE) and epinephrine (E) levels were assessed before, during, and after each clamp. RESULTS Resulting data showed that plasma catecholamine levels increased during baseline euglycemic-hyperinsulinemic clamp (NE: +23.6% time 0 vs. time 120 min, P &amp;lt; 0.05; E: +24.8% time 0 vs. time 120 min, P &amp;lt; 0.05). Captopril treatment significantly increased total glucose uptake (from 19.0 ± 9.0 to 26.8 ± 10.1 mmol·kg−1 · min−1, P &amp;lt; 0.05) and reduced baseline plasma NE (P &amp;lt; 0.001) and E (P &amp;lt; 0.05) levels. However, the magnitude of the NE (+25.7% time 0 vs. time 120 min, P &amp;lt; 0.001) and E (+27.2% time 0 vs. time 120 min, P &amp;lt; 0.05) increments during euglycemic hyperinsulinemia were not affected by the drug. Percentage changes in the ratio of total body glucose uptake to circulating insulin levels and corresponding decrements of baseline plasma E levels after captopril therapy were negatively correlated (r = −0.57, P &amp;lt; 0.05). CONCLUSIONS The reduction of circulating catecholamines could contribute, at least in part, to the captopril-related amelioration of insulin sensitivity.
Specialty Hospitals Under Fire
Authors: Mike Mitka
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1123 Hepatotoxicity and antiretroviral drugs in HIV-HCV patients with congenital coagulopathies followed at an haemophilia unit during a decade
Authors: V VARGAS, S SAULEDA, M MARTORELL, J ESTEBAN, C TURAL, I RUIZ, M TEJEDA, L PUIG, R ESTEBAN, J GUARDIA
Journal: Hepatology (2003)
Women doctors and family planning.
Authors: J Lawrie
Journal: BMJ (1973)

The author expresses concern that when family planning services are integrated into the British National Health Service, many of the women doctors working for the Family Planning Association will be without work. She asks that assurances be given to all doctors employed by the association that they will be so employed by area health authorities if they so desire. Further, long-term plans should be made to ensure that the family planning service is strengthened by becoming part of the gynecological and obstetric service. Indeed, it is hoped that all of the preventive services will become integral parts of the relevant specialty and not mere appendages.
Selective targeting of pentoxifylline to hepatic stellate cells using a novel platinum-based linker technology
Authors: Teresa Gonzalo, Eduard G. Talman, Anke van de Ven, Kai Temming, Rick Greupink, Leonie Beljaars, Catharina Reker-Smit, Dirk K.F. Meijer, Grietje Molema, Klaas Poelstra, Robbert J. Kok
Journal: Journal of Controlled Release (2006)
Blood Loss in the Right Proximal Thigh
Authors: James J Slavin, Christine L Vetter, Richard P Spencer
Journal: Clinical Nuclear Medicine (2004)

A 62-year-old man became progressively anemic immediately after a right total hip replacement. There was no evidence of gastrointestinal bleeding and the stool guaiac test remained negative. Because of a continued fall in the hematocrit, a Tc-99m red blood cell bleeding study was performed on postoperative day 9. This did not reveal any site of gastrointestinal bleeding. There was, however, progressive accumulation of activity in the right groin, consistent with continued active bleeding. The patient was treated conservatively and stabilized over the next several days.
(24) Keratosis pilarisatrophicans
Authors: A. Myatt, N.R. Rowell
Journal: British Journal of Dermatology (1987)

Journal Article (24) Keratosis pilarisatrophicans Get access A. Myatt, A. Myatt The General Infirmary at Leeds Search for other works by this author on: Oxford Academic Google Scholar N.R. Rowell N.R. Rowell The General Infirmary at Leeds Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue s32, 1 June 1987, Pages 71–72, https://doi.org/10.1111/j.1365-2133.1987.tb12064.x Published: 01 June 1987
Late Results of Treatment of Chronic Drug-resistant Pulmonary Tuberculosis
Authors: A. R. Somner, A. A. Brace
Journal: BMJ (1966)

Patients with active pulmonary tuberculosis of many years' duration are thought to have a reduced chance of being cured if they harbour tubercle bacilli resistant to streptomycin, para aminosalicylic acid (P.A.S.), and isoniazid. Three reasons are often given for this poor prognosis. Some patients cannot tolerate prolonged treatment with alternative chemotherapy? ethionamide, pyrazinamide, and cycloserine (the second line  drugs) ; the drugs may be less effective in eliminating tubercle bacilli from the sputum ; and they may fail to prevent the emergence of resistant strains.
The Patient-Centered Medical Home
Authors: George L. Jackson, Benjamin J. Powers, Ranee Chatterjee, Janet Prvu Bettger, Alex R. Kemper, Vic Hasselblad, Rowena J. Dolor, R. Julian Irvine, Brooke L. Heidenfelder, Amy S. Kendrick, Rebecca Gray, John W. Williams
Journal: Annals of Internal Medicine (2013)

Background: The patient-centered medical home (PCMH) describes mechanisms for organizing primary care to provide high-quality care across the full range of individuals' health care needs. It is being widely implemented by provider organizations and third-party payers. Purpose: To describe approaches for PCMH implementation and summarize evidence for effects on patient and staff experiences, process of care, and clinical and economic outcomes. Data Sources: PubMed (through 6 December 2011), Cumulative Index to Nursing & Allied Health Literature, and the Cochrane Database of Systematic Reviews (through 29 June 2012). Study Selection: English-language trials and longitudinal observational studies that met criteria for the PCMH, as defined by the Agency for Healthcare Research and Quality, and included populations with multiple conditions. Data Extraction: Information on study design, populations, interventions, comparators, financial models, implementation methods, outcomes, and risk of bias were abstracted by 1 investigator and verified by another. Data Synthesis: In 19 comparative studies, PCMH interventions had a small positive effect on patient experiences and small to moderate positive effects on the delivery of preventive care services (moderate strength of evidence). Staff experiences were also improved by a small to moderate degree (low strength of evidence). Evidence suggested a reduction in emergency department visits (risk ratio [RR], 0.81 [95% CI, 0.67 to 0.98]) but not in hospital admissions (RR, 0.96 [CI, 0.84 to 1.10]) in older adults (low strength of evidence). There was no evidence for overall cost savings. Limitation: Systematic review is challenging because of a lack of consistent definitions and nomenclature for PCMH. Conclusion: The PCMH holds promise for improving the experiences of patients and staff and potentially for improving care processes, but current evidence is insufficient to determine effects on clinical and most economic outcomes.
The Last Gift
Authors: Daniel Shapiro
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Measurement of Serum α1-Acid Glycoprotein and cei-Antitrypsin Desialylation in Liver Disease
Authors: Nathalie Serbource-Goguel, Michèle Corbic, Serge Erlinger, Geneviève Durand, Jean Agneray, Jeanne Feger
Journal: Hepatology (1983)

To determine whether the presence of circulating desialylated glycoproteins reflect the existence and/or the severity of liver disease, 73 patients were evaluated with liver biopsies, conventional liver function tests, and the measurement of the degree of desialylation of two glycoproteins alpha 1-acid glycoprotein (alpha 1-AGP) and alpha 1-antitrypsin (alpha 1-AT). A combination of two immunological methods, available as routine laboratory tests, was used for the determination of the desialylation of alpha 1-AGP and alpha 1-AT. The severity of liver disease was assessed by a clinical classification depending upon the presence or absence of four complications (jaundice, ascites, hepatic encephalopathy, and weight loss). The presence of serum desialylated alpha 1-AGP did not allow detection of mild liver disease, but asialo alpha 1-AGP (and to a lesser extent of asialo-alpha 1-(AT) correlated with the severity of liver disease. The sensitivity of desialylated alpha 1-AGP in detection of severe liver disease was 65%, and its specificity was 80%.
The preregistration houseman in general practice.
Authors: G K Freeman, C R Coles
Journal: BMJ (1982)

During 1979-80 an experimental preregistration house physician post in general practice was conducted at Aldermoor Health Centre in Southampton in rotation with medical posts at Southampton General Hospital. Ten house physicians took part in the experiment that lasted for 19 months and each doctor spent two months in general practice. The house physicians settled quickly into general practice and found the experience both enjoyable and worth while. The hospital consultants, general practitioners, and the house physicians themselves thought that this was a valuable extension to preregistration education. The experiment raised several questions, some of which were specific to the type of rotation organised and others that were more fundamental to the whole concept of the preregistration house physician in general practice. If the experiment is to be repeated a longer period in general practice is strongly recommended. A full year rotation is suggested with four months each of surgery, medicine, and general practice.
Secondary Respiratory Infection in Hospital Patients: Effect of Antimicrobial Agents and Environment
Authors: J. R. Philp, R. C. Spencer
Journal: BMJ (1974)

A prospective study of 358 medical and 234 postoperative patients with clinical evidence of secondary chest infection showed that previous administration of antimicrobial agents greatly reduced the chance of obtaining a clear-cut laboratory report. In patients with radiographical evidence of pneumonia this led to a fourfold decrease in the overall rate of isolation of potential pathogens. Furthermore, 81 diverse "coliforms" were isolated from 258 medical and surgical patients who had received previous antimicrobial therapy while only four coliforms (all Escherichia coli) were isolated from 334 untreated patients. Thus the general hospital environment on its own seemed to have a negligible influence in promoting the growth of coliform flora in sputum. Any unique effect of underlying disease in this regard was masked by that of previous therapy. Finally, the results raised the possibility that previous antimicrobial therapy might have increased the risk of secondary pneumonia in hospital patients.
Evidence for Active Epstein-Barr Virus Infection in Patients with Persistent, Unexplained Illnesses: Elevated Anti-Early Antigen Antibodies
Authors: JAMES F. JONES
Journal: Annals of Internal Medicine (1985)

Forty-four patients, including 26 adults and 18 children under 15 years of age, were referred for evaluation of recurrent or persistent illnesses, with symptoms including pharyngitis, lymphadenopathy, fever, headaches, arthralgia, fatigue, depression, dyslogia, and myalgia. Thirty-nine patients were positive for Epstein-Barr virus antibody with antibody levels compatible with active infection for at least 1 year. Antiviral capsid antigen and anti-early antigen titers of patients were significantly greater (p less than 0.001) than age-group-matched controls. The frequency, number, duration, and patterns of symptoms, as well as patient sex, were compared by age in study patients seropositive and seronegative for Epstein-Barr virus. Illness patterns were not associated with changes in specific antibody titers or clinical findings. Lymphocyte phenotype and function analyses were done in 11 of the 39 patients positive for Epstein-Barr virus antibody; no consistent differences from normal were found. Only 1 of 32 patients had circulating interferon, in contrast to 7 of 7 patients with acute infectious mononucleosis. There were many adverse consequences of the illness. Epstein-Barr virus infection may not be self-limiting, and the virus may be associated with clinically recognizable illness other than infectious mononucleosis in children as well as in adults.
Audit Commission tackles anaesthetic services
Authors: A. Smith
Journal: BMJ (1998)

office based, and treatment home based, with great convenience, savings, and no apparent loss in safety.All this good news does not represent the requiem for the venogram.Contrast venography will remain essential for the foreseeable future for diagnosing symptomatic calf thromboses that do not extend proximally, previously thrombosed legs again symptomatic, or asymptomatic leg thromboses in patients with or at risk of pulmonary embolism 11 and for evaluating the efficacy of antithrombotic and thrombolytic drugs and of new imaging and patient management techniques (like the Cogo study).Promising uses of ultrasound contrast agents are being investigated in organ imaging, but there is little firm progress to report on from contrast ultrasound imaging of the deep veins. 12This study indeed does represent a highly useful and generalisable advance for a large segment of our patients, but we still have a long way to go.
Assessing the consultation: methods of observing trainees in general practice.
Authors: M Pringle, S Robins, G Brown
Journal: BMJ (1984)

We compared two different methods of observing trainees at work in general practice: the traditional one of a senior or training general practitioner sitting in during selected surgeries and the more modern video recording, with the patients' written consent. Patients who had experienced the presence of a second doctor during the consultation were less likely to show an increase in arousal after their consultations than those who had been recorded on video. Patients who refused consent to be recorded were more highly stressed than those who agreed and showed smaller decreases in stress after consultations. The presence of two doctors generated fewer reductions in stress after the consultation than video recording did, but this was a non-significant trend. The group that was recorded on video did not differ appreciably from a control group in changes in stress or arousal.
Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas
Authors: Yuchen Jiao, Timothy M Pawlik, Robert A Anders, Florin M Selaru, Mirte M Streppel, Donald J Lucas, Noushin Niknafs, Violeta Beleva Guthrie, Anirban Maitra, Pedram Argani, G Johan A Offerhaus, Juan Carlos Roa, Lewis R Roberts, Gregory J Gores, Irinel Popescu, Sorin T Alexandrescu, Simona Dima, Matteo Fassan, Michele Simbolo, Andrea Mafficini, Paola Capelli, Rita T Lawlor, Andrea Ruzzenente, Alfredo Guglielmi, Giampaolo Tortora, Filippo de Braud, Aldo Scarpa, William Jarnagin, David Klimstra, Rachel Karchin, Victor E Velculescu, Ralph H Hruban, Bert Vogelstein, Kenneth W Kinzler, Nickolas Papadopoulos, Laura D Wood
Journal: Nature Genetics (2013)
Case reports of suspected adverse drug reactions: Case reports generate signals efficiently
Authors: Stefan Russmann
Journal: BMJ (2006)

EDITOR—Loke et al judge the value of case reports of suspected adverse drug reactions by the outcome measures of further formal validation and the incorporation into the product information.1 They conclude that such reports are of limited value.

The main sources of information or tools that are available for detecting and evaluating suspected adverse drug reactions are spontaneous reports, formal …
A regional outbreak of S. Typhimurium in Denmark and identification of the source using MLVA typing
Authors: M Torpdahl, G Sørensen, S Ethelberg, G Sandø, K Gammelgard, L Jannok Porsbo
Journal: Eurosurveillance (2006)

In Denmark, as part of the national laboratory-based surveillance system of human enteric infections, all S. Typhimurium isolates are currently sub-typed using phage typing, antibiogram typing, and pulsed-field gel electrophoresis (PFGE). However, the discriminatory ability of PFGE is not always high enough to discriminate within certain phage types, and it is not always possible to separate unrelated and related isolates. We have therefore applied multiple locus variable number of tandem repeats analysis (MLVA) for surveillance typing of S. Typhimurium since 2004. In May and June 2005, an outbreak with 26 cases of S. Typhimurium infection was identified by MLVA. The isolates were fully sensitive and had one of the most frequently occurring Danish phage types (DT12) and PFGE types. S. Typhimurium DT12 isolates from routine surveillance of animals and food were typed using MLVA and PFGE for comparison with the human isolates. The typing results revealed that an isolate from a pig herd and its corresponding slaughterhouse located in the same geographic region as the outbreak had the same PFGE and MLVA type as the human isolates. In contrast, all other DT12 isolates investigated, which had the same PFGE profile, had different MLVA types. The conclusion that the pig herd was the source of the human infections was supported by patient information, and pork from the herd stopped entering the market on 29 June. MLVA may contribute significantly to both surveillance and outbreak investigations of S. Typhimurium, as without MLVA typing this outbreak would not have been found nor its origin traced.
Familial non-polypotic carcinoma of colon.
Authors: J. F. Fielding
Journal: BMJ (1969)

of ketone bodies and lactate.The modem spectrophotometric enzymic methods have greatly simplified the determination of ketone bodies6 and lactate.7It should also be noted that the determination of lactate in serum may lead to spuriously high values due to lactic acid production during red cell gly- colysis.-Weare, etc.,