tbuckley/cabot-search huggingface dataset:
INCREASED PULSE WAVE VELOCITY IS ASSOCIATED WITH CORONARY ARTERY CALCIUM IN ASYMPTOMATIC INDIVIDUALS
Authors: Souraya Sourayanezhad, Naser Ahmadi, Vahid Nabavi, Braynce L. Oyang, Shahin Moshrefi, Sagar J. Pathak, Hussain sma’eel, Ramin Ebrahimi, Tae Young Choi, Anila Saeed, Matthew Budoff
Journal: Journal of the American College of Cardiology (2010)
PTU-115 Identifying Nafld In Patients Attending A Lipid Clinic – Do Non-invasive Scoring Systems For Fibrosis Have A Role?
Authors: L Wong, M Roberts, R McCorry
Journal: Gut (2014)

<h3>Introduction</h3> Hyperlipidaemia is a recognised risk factor for the development of non-alcoholic fatty liver disease (NAFLD). Aspartate aminotransferase (AST):alanine aminotransferase (ALT) ratio, AST-to-Platelet Ratio Index (APRI) and Fibrosis-4 (FIB-4) scores are validated, indirect, non-invasive methods which can be employed to exclude the possibility of hepatic fibrosis in the context of NAFLD.<sup>1</sup> The aim of this study was to apply these indices to patients attending a lipid clinic, with an elevated ALT to determine what proportion would merit further hepatology assessment. <h3>Methods</h3> We performed retrospective analysis of patients attending a lipid clinic in a university teaching hospital from 2011–2013. None of the patients were under gastroenterology/hepatology follow-up. In those with elevated ALT (&gt;30 IU/L male, &gt;19 IU/L female<sup>2</sup>) we calculated the AST:ALT ratio, APRI and FIB-4 scores. <h3>Results</h3> 130 patients were included (68 male, 62 female; mean age 54 (17–93)). Platelet data was available for 113 patients and 69 (53.0%) had elevated ALT (52% male). In these patients the scoring systems demonstrated an AST:ALT ratio &gt;0.8 in 32 (46.4%), APRI &gt;0.51 in 20 (30.0%) and FIB-4 &gt;1.46 score in 14 (20.3%). 11 (15.9%) had high scores across all 3 indices. <h3>Conclusion</h3> We have demonstrated that a significant proportion of patients with lipid abnormalities and raised ALT may be at risk of NAFLD with fibrosis. By using a composite of these scoring systems it may be possible to identify those who would benefit most from assessment in hepatology outpatients with staging of fibrosis. <h3>References</h3> Stuart McPherson, Stephen F Stewart, Elsbeth Henderson, Alastair D Burt, Christopher P Day. Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients withnon-alcoholic fatty liver disease.<i> Gut</i> 2010:59:1265–1269 Prati D, Taioli E, Zanella A, Della Torre E, Butelli S, Del Vecchio E, Vianello L, Zanuso F, Mozzi F, Milani S, Conte D, Colombo M, Sirchia G. Updated definitions of healthy ranges for serum alanine aminotransferase levels. <i>Ann Intern Med</i> 2002 Jul 2;137(1):1–10 <h3>Disclosure of Interest</h3> None Declared.
Animal rights vs research? A question of the nation's scientific literacy
Authors: D. L. Breo
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>Ustilago</i> species infection in humans
Authors: L.H.Y. Teo, Y.K. Tay
Journal: British Journal of Dermatology (2006)

Journal Article Ustilago species infection in humans Get access L.H.Y. Teo, L.H.Y. Teo Division of Dermatology, Changi General Hospital, 2 Simei Street 3, Singapore 529889, Singapore E‐mail: lynnteohweeying@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar Y.K. Tay Y.K. Tay Division of Dermatology, Changi General Hospital, 2 Simei Street 3, Singapore 529889, Singapore E‐mail: lynnteohweeying@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 155, Issue 5, 1 November 2006, Pages 1096–1097, https://doi.org/10.1111/j.1365-2133.2006.07515.x Published: 01 November 2006
Endovascular β-Radiation to Reduce Restenosis After Coronary Balloon Angioplasty
Authors: Spencer B. King, David O. Williams, Prakash Chougule, J. Larry Klein, Ron Waksman, Richard Hilstead, Joan Macdonald, Kris Anderberg, Ian R. Crocker
Journal: Circulation (1998)

In the porcine overstretch injury model of restenosis, endovascular beta-radiation reduces neointima formation. To determine whether this therapy could be applied to patients with coronary artery disease, a special device was developed to allow delivery of 12 encapsulated 90Sr/Y sources, measuring a total of 30 mm, to various sites within the coronary arterial tree. This study was designed to evaluate the feasibility of the delivery of 12, 14, or 16 Gy at 2 mm after balloon angioplasty of stenoses of native coronary vessels.Delivery of beta-radiation was attempted in 23 patients after successful balloon angioplasty. Source delivery was successful in 21 of the 23 patients (91%). There was no in-hospital or 30-day morbidity or mortality. Follow-up quantitative coronary arteriography in 20 patients demonstrated a late loss of 0.05 mm, a late loss index of 4%, and a restenosis rate of 15%. The use of the beta-emitter 90Sr/Y significantly reduced treatment time and operator exposure compared with previous trials with the gamma-emitter 192Ir.In this study, the administration of endovascular beta-radiation after angioplasty was safe and feasible and substantially altered the postangioplasty late lumen loss, resulting in a lower-than-expected rate of restenosis. On the basis of these encouraging results, a multicenter, randomized trial with operators and patients blinded to treatment assignment is planned.
PRIMARY SARCOMA OF THE LUNG
Authors: S. W. Curl
Journal: BMJ (1908)

PRIMEARY SARCOMA OF LUNG.[JUS 13, 19a.chest in respiration affect considerably the size of the smaller radial pulse.Indeed, a deep Inspiration will often abolish the inequality, and a forced expiration will exaggerate it-a phenomenon that -is to be explatned by tbe fact that In the majority of cases the lneqAality is the result of-compression of the artery by the sac rather than internal narrowing of the lumen of the vesie!, which pressure is relieved by the expansion of the chesh.Not only may the pmlse be redaced in size, but it is often delayed.The dysphagia resulting from pressure of a sac from the descending transverse portton of the arch upon the oseophagus seldom amounts to serious obatruction, and may affect both flaids and solids, but more freqaently the latter.The symptom varies much from week to week, and not infrequently passes off altogether.The patient, as a rale, pDints to the lower end of the sternum as the fancied site of obstruction.Paralysis of the vocal cords is not always attended by hoarseness, therefore a searchtag laryngoscopical examina- tion should -be made in every case.The abductors are
Prevention of Diabetic Neuropathy by Regulatable Expression of HSV-Mediated Erythropoietin
Authors: Zetang Wu, Marina Mata, David J Fink
Journal: Molecular Therapy (2010)

Previous studies have demonstrated that gene transfer of genes coding for neurotrophic factors to the dorsal root ganglion (DRG) using nonreplicating herpes simplex virus (HSV)–based vectors injected subcutaneously can prevent the progression of diabetic neuropathy. Because prolonged expression of neurotrophic factors could potentially have unwanted adverse effects, we constructed a nonreplicating HSV vector, vHrtEPO, to express erythropoietin (EPO) under the control of a tetracycline response element (TRE)-minimal cytomegalovirus (CMV) fusion promoter. Primary DRG neurons in culture infected with vHrtEPO express and release EPO in response to exposure to doxycycline (DOX). Animals infected with vHrtEPO by footpad inoculation demonstrated regulated expression of EPO in DRG under the control of DOX administered by gavage. Mice rendered diabetic by injection of streptozotocin (STZ), inoculated with vHrtEPO, and treated with DOX 4 days out of 7 each week for 4 weeks were protected against the development of diabetic neuropathy as assessed by electrophysiologic and behavioral measures. These studies indicate that intermittent expression of EPO in DRG achieved from a regulatable vector is sufficient to protect against the progression of neuropathy in diabetic animals, and provides proof-of-principle preclinical evidence for the development of such vectors for clinical trial. Previous studies have demonstrated that gene transfer of genes coding for neurotrophic factors to the dorsal root ganglion (DRG) using nonreplicating herpes simplex virus (HSV)–based vectors injected subcutaneously can prevent the progression of diabetic neuropathy. Because prolonged expression of neurotrophic factors could potentially have unwanted adverse effects, we constructed a nonreplicating HSV vector, vHrtEPO, to express erythropoietin (EPO) under the control of a tetracycline response element (TRE)-minimal cytomegalovirus (CMV) fusion promoter. Primary DRG neurons in culture infected with vHrtEPO express and release EPO in response to exposure to doxycycline (DOX). Animals infected with vHrtEPO by footpad inoculation demonstrated regulated expression of EPO in DRG under the control of DOX administered by gavage. Mice rendered diabetic by injection of streptozotocin (STZ), inoculated with vHrtEPO, and treated with DOX 4 days out of 7 each week for 4 weeks were protected against the development of diabetic neuropathy as assessed by electrophysiologic and behavioral measures. These studies indicate that intermittent expression of EPO in DRG achieved from a regulatable vector is sufficient to protect against the progression of neuropathy in diabetic animals, and provides proof-of-principle preclinical evidence for the development of such vectors for clinical trial.
The Determining Factor in Mouth-to-Mouth Respiration
Authors: Paleul J. Flagg
Journal: JAMA (1963)

<h3>To the Editor:</h3> —Proponents of mouth-to-mouth artificial respiration appear to have overlooked the determining factor in its success. Air can enter the esophagus or the larynx, distending the stomach or inflating the lungs. How can air be diverted away from the esophagus into the larynx?<i>By shutting off the esophagus through extension of the head</i>. This maneuver compresses the soft esophagus between the relatively rigid trachea and the convex (from extension of the head) anterior surface of the cervical vertebrae. To prove this compression, try to swallow with the head extended.
The natural oestrogenic hormone oestradiol as a new component of combined oral contraceptives.
Authors: B Astedt, L Svanberg, S Jeppsson, P Liedholm, G Rannevik
Journal: BMJ (1977)

The synthetice estrogenic compound ethinyl estradiol depresses the activator content of vessel walls. Biologically equivalent doses of the natural estrogenic hormone estradoil do not have this effect. Estradiol also impairs liver function  less than synthetic estrogens. Estradiol is a natural estrogen obtained from soy beans. The new Micronizing technique favors absorption. The effects of a pill designated Netagen containing 4 mg of micronized estradiol and 3 mg of  norethisterone were studied over a 1-year period. The pill was taken for 21 consectutive days and withdrawn for 7 days of consecutive cycles. Subjects were 25 normal women. No pregnancies or throbmoembolic incidents occurred in 204 cycles.  Spotting was noted by 7 patients.  2 developed amenorrhea but 1 of them had previously had amenorrhea. Emotional disturbances were noted by 2. The menstrual flow was unchanged in 12 and decreased in 13. No increase in blood pressure was recorded. Weight increased in 4 and  decreased in 2. 11 of the 25 women stopped taking the pill after 3-6 months;  the other 14 continued. Results of this pilot study suggest that this preparation may be an improvement as a new combined oral contraceptive as it seems less likely to cause thromboembolic complications.
Primary angioplasty versus systemic thrombolysis in anterior myocardial infarction
Authors: Eulogio Garcı́a, Jaime Elı́zaga, Nicasio Pérez-Castellano, Jose A Serrano, Javier Soriano, Manuel Abeytua, Javier Botas, Rafael Rubio, Esteban López de Sá, Jose L López-Sendón, Juan L Delcán
Journal: Journal of the American College of Cardiology (1999)
Ribosomal DNA Integrating rAAV-rDNA Vectors Allow for Stable Transgene Expression
Authors: Leszek Lisowski, Ashley Lau, Zhongya Wang, Yue Zhang, Feijie Zhang, Markus Grompe, Mark A Kay
Journal: Molecular Therapy (2012)

Although recombinant adeno-associated virus (rAAV) vectors are proving to be efficacious in clinical trials, the episomal character of the delivered transgene restricts their effectiveness to use in quiescent tissues, and may not provide lifelong expression. In contrast, integrating vectors enhance the risk of insertional mutagenesis. In an attempt to overcome both of these limitations, we created new rAAV-rDNA vectors, with an expression cassette flanked by ribosomal DNA (rDNA) sequences capable of homologous recombination into genomic rDNA. We show that after in vivo delivery the rAAV-rDNA vectors integrated into the genomic rDNA locus 8–13 times more frequently than control vectors, providing an estimate that 23–39% of the integrations were specific to the rDNA locus. Moreover, a rAAV-rDNA vector containing a human factor IX (hFIX) expression cassette resulted in sustained therapeutic levels of serum hFIX even after repeated manipulations to induce liver regeneration. Because of the relative safety of integration in the rDNA locus, these vectors expand the usage of rAAV for therapeutics requiring long-term gene transfer into dividing cells. Although recombinant adeno-associated virus (rAAV) vectors are proving to be efficacious in clinical trials, the episomal character of the delivered transgene restricts their effectiveness to use in quiescent tissues, and may not provide lifelong expression. In contrast, integrating vectors enhance the risk of insertional mutagenesis. In an attempt to overcome both of these limitations, we created new rAAV-rDNA vectors, with an expression cassette flanked by ribosomal DNA (rDNA) sequences capable of homologous recombination into genomic rDNA. We show that after in vivo delivery the rAAV-rDNA vectors integrated into the genomic rDNA locus 8–13 times more frequently than control vectors, providing an estimate that 23–39% of the integrations were specific to the rDNA locus. Moreover, a rAAV-rDNA vector containing a human factor IX (hFIX) expression cassette resulted in sustained therapeutic levels of serum hFIX even after repeated manipulations to induce liver regeneration. Because of the relative safety of integration in the rDNA locus, these vectors expand the usage of rAAV for therapeutics requiring long-term gene transfer into dividing cells.
A Further Account of the Idiots Savants, Experts with the Calendar
Authors: WILLIAM A. HORWITZ, W. EDWARDS DEMING, ROBERT F. WINTER
Journal: American Journal of Psychiatry (1969)

The authors present a further account of twins, classifiable as idiots savants, whose ability to name the day of the week for a given date in any year, and the converse, has led to conjecture on the mechanism by which they perform the feat. Their method is explained as the ability to subtract multiples of a 400-year calendar cycle from any given year.
T and B lymphocyte abnormalities in bone marrow biopsies of common variable immunodeficiency
Authors: Manuella L. Gomes Ochtrop, Sigune Goldacker, Annette M. May, Marta Rizzi, Ruth Draeger, Dieter Hauschke, Claudia Stehfest, Klaus Warnatz, Heike Goebel, Katja Technau-Ihling, Martin Werner, Ulrich Salzer, Hermann Eibel, Michael Schlesier, Hans Hartmut Peter
Journal: Blood (2011)
Defining Risks of Taxane Neuropathy: Insights from Randomized Clinical Trials
Authors: David Kudlowitz, Franco Muggia
Journal: Clinical Cancer Research (2013)

Abstract Sensory neuropathy is a common but difficult to quantify complication encountered during treatment of various cancers with taxane-containing regimens. Docetaxel, paclitaxel, and its nanoparticle albumin-bound formulation have been extensively studied in randomized clinical trials comparing various dose and schedules for the treatment of breast, lung, and ovarian cancers. This review highlights differences in extent of severe neuropathies encountered in such randomized trials and seeks to draw conclusions in terms of known pharmacologic factors that may lead to neuropathy. This basic knowledge provides an essential background for exploring pharmacogenomic differences among patients in relation to their susceptibility of developing severe manifestations. In addition, the differences highlighted may lead to greater insight into drug and basic host factors (such as age, sex, and ethnicity) contributing to axonal injury from taxanes. Clin Cancer Res; 19(17); 4570–7. ©2013 AACR.
Abstract 2324: LHT-7 as multi-targeting and anti-angiogenic agent to growth factor receptors
Authors: Sang Mun Bae, Rang-Woon Park, Yoonjae Jung, Yang Yoo-Jin, Lianhua Chi, Youngro Byun
Journal: Cancer Research (2012)

Abstract Angiogenesis is a highly regulated process that is critical for tumor growth and metastasis. Angiogenesis depends on the balance between different molecules released by the host and tumor cells such as vascular endothelial growth factor (VEGF), fibroblast growth factor basic (bFGF), platelet-derived endothelial cell growth factor (PDGF), insulin-like growth factors (IGF-1 and IGF-2) and scatter factor, which are potential targets for development of angiogenesis inhibitor and depend on heparin sulfate for their biological functions. Heparan sulfate is located in cell surface and in the extracellular matrix and plays crucial regulatory roles in some growth factors. For this reason, heparin has been highlighted as a therapeutic agent as well as anticoagulant. In a previous study, we reported new angiogenesis inhibitor, low molecular weight heparin derivative (heparin-taurocholic acid conjugate; LHT-7) and it showed delay of in vivo tumor growth in MDA-MB231 human breast cancer and inhibited phosphorylation of VEGFR2 through the interaction with VEGF in human umbilical vein endothelial cells (HUVECs). In present study, we revealed LHT-7 as multi-targeting agent to several growth factors and on their actions. LHT7 inhibited phosphorylation of VEGFR2 and binding of LHT7 was increased in VEGFR2 over-expressing HEK293 by FACS analysis. In HUVECs, binding of LHT-7 was shown in a dose-dependent manner by FACS analysis and co-localized with VEGFR2 by immunofluorescence. LHT-7 also inhibited vessel formation enhanced by PDGF-bb in matrigel plug assay and phosphorylation of PDGFR-ß in human vascular smooth muscle cell (HuVSMC). Binding of LHT-7 was increased in a dose-dependent manner by FACS analysis and decreased in PDGFR-ß-siRNA HuVSMC by immunofluorescence. Finally, LHT-7 inhibited phosphorylation of FGFR-1 in HUVECs and binding of LHT-7 was decreased in FGFR-1-siRNA MDA-MB-361. Overall, LHT-7 has inhibitory effect on phosphorylation of growth factors and binding of LHT-7 was increased in a dose-dependent manner but decreased in a growth factor down-regulated cell. Therefore we suggest that LHT7 would target to VEGFR2, PDGFR- ß and FGFR-1 and inhibit their angiogenic roles. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2324. doi:1538-7445.AM2012-2324
Res ipsa loquitur. 1. Obstetrics
Authors: A. R. Holder
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trigeminal trophic syndrome
Authors: Renwick Vickers
Journal: British Journal of Dermatology (1983)

Journal Article Trigeminal trophic syndrome Get access Renwick Vickers Renwick Vickers The Old Smithy, Little Milton, Oxford 0X9 7PU Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 109, Issue 3, 1 September 1983, Page 369, https://doi.org/10.1111/j.1365-2133.1983.tb03558.x Published: 01 September 1983
OPERATION-DAY BLOOD-TRANSFUSION AND RENAL TRANSPLANTATION
Authors: J.K. Cruickshank, M.H. Simms, A.R. De Bolla, C.R. Stiller, N.R.Stc Sinclair, B. Lockwood, JohnR. Salaman, G.G. Persijn, J.J. Van Rood
Journal: The Lancet (1978)
From sequence to functional understanding: the difficult road ahead
Authors: Periklis Makrythanasis, Stylianos E Antonarakis
Journal: Genome Medicine (2011)

DNA sequencing has become cheap, rapid and accurate, allowing us to access thousands of genomes and reveal the extensive variation among individuals. The major problem that arises from this is distinguishing between neutral and pathogenic variants. A recent study by Davis et al., in which a functional screen of all the non-synonymous variants of a newly discovered gene was performed, highlights the value and necessity of characterizing the functional consequences of each genomic variant discovered. This is the main challenge for the advancement of genomic medicine in the years to come.
Most US citizens with major depression are untreated or undertreated
Authors: J. H. Tanne
Journal: BMJ (2010)

Few US citizens with major depression are appropriately treated with Mexican-Americans and African-Americans the least likely to receive treatment recommended in national guidelines, a study has found ( Arch Gen Psych 2010;67:37-46).

Another study in the same journal says that office based psychiatrists are increasingly prescribing two and three antidepressant and antipsychotic drugs, including some combinations of unproved efficacy, putting patients at heightened risk of drug interactions and with uncertain clinical gains ( Arch Gen Psych 2010;67:26-36).

The first study looked at the …