tbuckley/cabot-search huggingface dataset:
Primary Type V Hyperlipoproteinemia in Childhood
Authors: Daniel Yeshurun, Hong Chung, Antonio M. Gotto, O. David Taunton
Journal: JAMA (1977)

Metabolic studies of a 9-year-old girl with primary type V hyperlipoproteinemia demonstrated normal glucose tolerance, plasma insulin and glucagon responses to stimuli, and serum uric acid level. Fasting plasma triglyceride levels rapidly increased when the patient received a diet containing 40% of the total calories as fat and rapidly decreased on a 10% fat diet. Hepatic and nonhepatic lipase activities in postheparin plasma were normal, thus excluding type I hyperlipoproteinemia. Because of the potential complication of acute pancreatitis in this disorder, early diagnosis and prompt institution of diet therapy is important. (<i>JAMA</i>238:2518-2520, 1977)
Effects of <i>RANTES</i> and <i>MBL2</i> gene polymorphisms in sickle cell disease clinical outcomes: Association of the g.In1.1T&gt;C <i>RANTES</i> variant with protection against infections
Authors: Omer Placide Dossou‐Yovo, Isabelle Zaccaria, Malika Benkerrou, Michelle Hauchecorne, Corinne Alberti, Mohamed Chérif Rahimy, Jacques Elion, Claudine Lapoumeroulie
Journal: American Journal of Hematology (2009)

Additional Supporting Information may be found in the online version of this article. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
DIAGNOSTIC CHARACTERISTICS OF HEADACHES ACCORDING TO THEIR ORIGIN.
Authors: H. GRADLE
Journal: JAMA (1898)

The object of the present paper is to point out those peculiarities of headaches which, can serve as guides in the search for their origin. The author's experience pertains principally to headaches dependent upon affections of the special senses. But valuable lessons, too, have been learned—in a negative sense—from the study of those cases which, on investigation, proved to be of different character. Before proceeding to details, I wish to explain the point of view from which I have been led to regard headaches of peripheral origin. While I agree with the general experience, that a large number of headaches start from some anomaly of the eyes or of the nose, I do not think that the detection of such a peripheral origin ends the investigation of the case. We must consider not merely the peripheral lesion, but also the condition of the nervous system. There are, indeed, certain peripheral
Efficiency in the Health Care Industries
Authors: Andrew S. Grove
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Post myocardial infarction (MI) management patterns of pattents in the survival and ventricular enlargement (SAVE) study at Canadian and US Centers
Authors: J.L. Rouleau, J.M.O. Arnold, V. Bernstein, T.E. Cuddy, G.R. Dagenais, E.M. Geltman, S. Goldman, D. Gordon, G. Lamas, J. McCans, P. McEwan, F.J. Menapace, J.O. Parker, M.A. Pfeffer, F. Sestier, B. Sussexfor
Journal: Journal of the American College of Cardiology (1990)
An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia
Authors: Birgit Knoechel, Justine E Roderick, Kaylyn E Williamson, Jiang Zhu, Jens G Lohr, Matthew J Cotton, Shawn M Gillespie, Daniel Fernandez, Manching Ku, Hongfang Wang, Federica Piccioni, Serena J Silver, Mohit Jain, Daniel Pearson, Michael J Kluk, Christopher J Ott, Leonard D Shultz, Michael A Brehm, Dale L Greiner, Alejandro Gutierrez, Kimberly Stegmaier, Andrew L Kung, David E Root, James E Bradner, Jon C Aster, Michelle A Kelliher, Bradley E Bernstein
Journal: Nature Genetics (2014)
Bran's deleterious effects: much ado about nothing
Authors: A. C Ford, P. Moayyedi
Journal: BMJ (2009)

Bijkerk and colleagues’ randomised controlled trial of soluble and insoluble fibre supplementation in irritable bowel syndrome is the first to be conducted entirely in primary care.1

In a systematic review and meta-analysis of trials in specialist settings, our group reported a beneficial effect of soluble fibre in the form of psyllium …
One Step Closer to “Rejectostix”
Authors: Julie R. Ingelfinger, Stephen I. Alexander
Journal: New England Journal of Medicine (2013)

Before the era of molecular diagnostics, nephrologists caring for transplant patients talked about future transplant management in which there would be "Rejectostix," similar to the dipsticks used in routine urinalysis. This hypothetical product would allow the detection of allograft rejection before symptoms occurred and would greatly improve outcome. Identification of early rejection markers has been elusive. However, as kidney transplantation has become common, with 16,485 renal transplantations in the United States in 2012,1 the goal of presymptomatic, noninvasive detection of rejection has begun to move forward.In this issue of the Journal, Suthanthiran and colleagues2 report results from a multicenter . . .
THE VIRUS OF INFECTIOUS FELINE AGRANULOCYTOSIS
Authors: J. S. Lawrence, J. T. Syverton, R. J. Ackart, W. S. Adams, D. M. Ervin, A. L. Haskins, R. H. Saunders, M. B. Stringfellow, R. M. Wetrich
Journal: The Journal of Experimental Medicine (1943)

The infection of cats by the virus of infectious feline agranulocytosis is followed by the production of specific neutralizing and protective antibodies, and recovery from the disease is associated with the development of solid immunity to reinfection. From the evidence presented it is obvious that the virus is not related to the viruses of hog cholera, lymphocytic choriomeningitis, fox encephalitis, vesicular stomatitis, the Western type of equine encephalomyelitis, herpes, and B virus infection.
289 BONE MORPHOGENETIC PROTEIN 9 (BMP-9) TRIGGERS EPITHELIAL-MESENCHYMAL TRANSITION OF HEPATOCELLULAR CARCINOMA CELLS
Authors: Q. Li, H. Weng, Y. Liu, X. Gu, J. Dzieran, I. Iikavets, S. Ghafoory, S. Wölfl, C. Gao, S. Dooley, K. Breitkopf-Heinlein
Journal: Journal of Hepatology (2012)
50 PREGNANCY RESOLVES LIVER FIBROSIS AND IMPROVES SCLEROSING CHOLANGITIS IN MDR2 (ABCB4) −/− MICE VIA DIRECT ANTI-INFLAMMATORY EFFECTS OF SEX HORMONES
Authors: E. Halilbasic, T. Claudel, J. Gumhold, S. Halsegger, D. Silbert, P. Fickert, M. Trauner
Journal: Journal of Hepatology (2010)
Abstract 535: Expression of miR-21 in cancer associated fibroblasts in lung adenocarcinoma
Authors: Akiko Kunita, Shigeki Morita, Masashi Fukayama
Journal: Cancer Research (2014)

Abstract Lung cancer is the leading cause of cancer mortality worldwide, and novel therapeutic targets and molecular diagnostic markers are highly warranted. Micro RNAs (miRNAs) are a class of small non-coding RNAs associated with a variety of cancer. miRNA-21 is an “oncomiR” and upregulated in many cancers, including lung cancer, and high miR-21 levels have been associated with poor prognosis. To determine the localization of miR-21 and to compare its expression levels, we performed in situ hybridization of miR-21 on 89 mixed subtypes of lung adenocarcinoma. miR-21 was predominantly expressed in cancer associated fibroblasts (CAF)s expressing α-SMA, with no difference in expression between non-invasive and invasive component. In addition, stromal miR-21 expression was significantly associated with decreased overall survival (p=0.0021). In functional analyses of miR-21 in vitro, miR-21 was overexpressed in lung fibroblasts to assess migration and invasion. miR-21 expression in lung fibroblasts promoted migration and invasion. Moreover, the proliferation of lung cancer cells was accelerated by conditioned medium of miR-21-expressing lung fibroblasts. These results suggest that miR-21 overexpression in CAFs of lung adenocarcinoma might serve as a prognostic biomarker and be involved in cancer cell proliferation through interactions with cancer cells. Citation Format: Akiko Kunita, Shigeki Morita, Masashi Fukayama. Expression of miR-21 in cancer associated fibroblasts in lung adenocarcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 535. doi:10.1158/1538-7445.AM2014-535
Marriage: If It Lasts, Does That Mean It's Good?
Authors: Leon Eisenberg
Journal: JAMA (1989)

The two articles on physicians' marriages in this issue ofThe Journalappear, at first blush, to be contradictory. Doherty and Burge<sup>1</sup>report a careful statistical analysis of 1970 and 1980 census data; they conclude that male as well as female physicians are less likely to divorce than other employed Americans of the same sex, including those in other professions. Gabbard and Menninger<sup>2</sup>report on 11 years of experience with male physicians and their spouses who participated in family workshops; they conclude that physicians' compulsive personality traits result in a "strategy of postponement," an avoidance of intimacy, and serious, if covert, marital discord. How are we to reconcile these findings? Can both be right? The two studies differ in sampling frame and in methodology. Doherty and Burge employ a national database that yields large unbiased samples of physicians, some 15 000 for 1970 and some 86 000 for
Primary Angioplasty — Enduring the Test of Time
Authors: David P. Faxon, Joel W. Heger
Journal: New England Journal of Medicine (1999)

The role of mechanical reperfusion as compared with thrombolytic therapy for the treatment of acute myocardial infarction has remained controversial since Rentrop et al.1 first reestablished perfusion in patients with myocardial infarction by dislodging the occluding coronary thrombus with a guide wire. Since then, considerable evidence has shown that thrombolytic agents are effective in restoring blood flow, improving left ventricular function, and reducing mortality from acute myocardial infarction. Primary treatment with percutaneous transluminal coronary angioplasty has been shown to have similar benefits, and controversy continues over what method is more effective.Those who favor thrombolytic therapy emphasize its advantages over . . .
Abstract 2077: Snail modulates stemness properties in hypoxic Glioblastoma
Authors: Chitrangda srivastava, Khushboo Irshad, Arpit Sahu, Parthaprasad Chattopadhyay, Chitra Sarkar, Deepak kumar Gupta, Subrata Sinha, Kunzang Chosdol
Journal: Cancer Research (2014)

Abstract Introduction: Glioblastoma (GBM) is the most aggressive form of glioma characterized by hypoxic regions with surrounding areas of necrosis. Hypoxia is responsible for inducing cancer invasiveness via epithelial-mesenchymal transition (EMT), thereby promoting tumor aggressiveness and therapeutic resistance. HIF-1α is known to upregulate Snail in various cancers. Snail over expression correlates with cancer stem cell-like properties in cancers. The association of EMT and stemness properties plays a vital role in tumors progression and might helps in therapeutic targeting. We have, therefore, investigated the correlation of EMT and Stem cell markers in hypoxic GBM. Method: mRNA expression of 5 EMT, 3 stemness and 5 hypoxia markers were analyzed in the 31 GBM samples and U373MG glioma cell line maintained under normoxia (20% O2) and severe hypoxia (0.2% O2) conditions for 24, 48 and 72 hrs. Correlation and cluster analysis were applied using SPSS 11.5, Cluster 3.0 software etc and R-software. Result: In tumors, spearman correlation was found to be significant (p≤0.05) between EMT markers and Hypoxia markers. Of all EMT markers, Snail correlated significantly with the maximum hypoxia markers, including HIF-1α. In addition, Snail was significantly correlated with Stem cell markers SOX2 (p&amp;lt;0.01) and Nestin (p&amp;lt;0.05). Gene Cluster analysis in 31 GBM arranged in decreasing order of Snail expression showed significant upregulation of SOX2 and Nestin in the high Snail expressing tertile. This correlation of gene expression in tumors was validated by in-vitro expression analysis of the molecules in U373MG cells, where we assessed significant increase in the expression of hypoxia markers (HIF-1α, VEGF and CA9), EMT (Snail and LOX) and SC markers (SOX2 and OCT4) were significantly increased under severe hypoxic conditions. Interpretation &amp; conclusions: Our finding for the first time suggests the role of Snail in provoking stemness of cancer cells in hypoxic GBM, thereby promoting aggressiveness of GBM. Note: This abstract was not presented at the meeting. Citation Format: Chitrangda srivastava, Khushboo Irshad, Arpit Sahu, Parthaprasad Chattopadhyay, Chitra Sarkar, Deepak kumar Gupta, Subrata Sinha, Kunzang Chosdol. Snail modulates stemness properties in hypoxic Glioblastoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2077. doi:10.1158/1538-7445.AM2014-2077
Problems of Medical Licensure
Authors: Vasilios G. Letsou
Journal: JAMA (1969)

To the Editor:—  The problem of medical licensure by the states is becoming an increasing problem daily. Many efforts have been made to solve this problem and probably the Flex exam, recently instituted by the Federation of State Medical Boards of the United States is a step in the right direction. It does not, however, meet the requirements set up by a recent Presidential Commission that asked that all physicians practicing in the United States pass the same examination and be of similar backgrounds so that two standards of licensing physicians will no longer exist.  At the present time, the American graduate presents no particular problem. He is a graduate of schools which are regularly inspected and approved. Not only must he graduate from a school with good standing, but the school itself must meet standards set by competent authority. Most American graduates at the present time, at least in
The Future of Quality Measurement for Improvement and Accountability
Authors: Patrick H. Conway, Farzad Mostashari, Carolyn Clancy
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clonidine confused with 'Clonopin'
Authors: M. J. Brennan
Journal: JAMA (1984)

To the Editor.—  During the course of an evaluation for abdominal pain and nausea, a 30-year-old woman was referred to the neurology service for an opinion on her complex partial seizures. Four months before, Clonopin (clonazepam), 1 mg three times per day, had been added to her seizure treatment regimen, which included phenobarbital, carbamazepine, and valproic acid. Shortly thereafter, she began to experience bouts of abdominal discomfort and nausea, together with palpitations, flushing, and dizziness on standing from a sitting or lying position. Examination of her medications showed that she was taking clonidine instead of Clonopin. She stated that the pharmacist had assured her that this was the generic form of the drug and cheaper. The complaints subsided once the appropriate substitution was made.  More recently, a 35-year-old man called complaining of nausea and dizziness since starting therapy with Clonopin, 0.5-mg tablets, a half-tablet three times daily, which we prescribed
The Return of Acute Rheumatic Fever in Young Adults
Authors: MarkR. Wallace
Journal: JAMA (1989)

The incidence of acute rheumatic fever (ARF) in the United States has been steadily declining for three decades, and by the mid-1980s had virtually disappeared. In the past 3 years, however, several scattered outbreaks have occurred among US schoolchildren, and there is speculation that ARF will again become a major public health problem in North America. We report a clustering of 10 cases of ARF in young men undergoing basic training at a recruit camp in San Diego, Calif. This was the first such outbreak in two decades among US military personnel and the largest reported series of ARF cases among adults in more than a decade in the United States. Adult-onset ARF was not benign in our patients. The rate of carditis (3 of 10 patients) was similar to that in older studies of adults with ARF. All patients in our series suffered severe polyarthritis, anemia, and fever, but only 60% gave any history of preceding pharyngitis. Rheumatic fever must again be suspected in adults, as well as children, who present with polyarthritis.
Mutation of TBCE causes hypoparathyroidism– retardation–dysmorphism and autosomal recessive Kenny–Caffey syndrome
Authors: Ruti Parvari, Eli Hershkovitz, Nili Grossman, Rafael Gorodischer, Bart Loeys, Alexandra Zecic, Geert Mortier, Simon Gregory, Reuven Sharony, Marios Kambouris, Nadia Sakati, Brian F Meyer, Aida I Al Aqeel, Abdul Karim Al Humaidan, Fatma Al Zanhrani, Abdulrahman Al Swaid, Johara Al Othman, George A Diaz, Rory Weiner, K Tahseen S Khan, Ronald Gordon, Bruce D Gelb
Journal: Nature Genetics (2002)
Judge rules that baby boy should not be allowed to die
Authors: Clare Dyer
Journal: BMJ (2006)

A judge at the High Court in London last week refused to rule that an 18 month old boy with type 1 spinal muscular atrophy be allowed to die, against the unanimous opinion of medical experts involved in the case.

Mr Justice Holman ruled that it would not be in the best interests of the boy, named only by his initials MB, to be taken off the ventilator that is keeping him alive.

The case is the first in which a trust has sought a declaration that life support for a child who is assumed to have normal cognitive functioning should be …
Abstract 1534: Hes1 regulates hypoxia induced chemoresistance of myeloma cells
Authors: Tuhin Das, Alexandra Pisklakova, Zhaoliang Fei, Yulia Nefedova
Journal: Cancer Research (2012)

Abstract Bone marrow (BM) microenvironment plays a critical role in response of tumor cells to chemotherapeutic drugs. Hypoxia has been shown to contribute to pathogenesis not only solid but also hematological tumors. While normal BM environment is hypoxic, tumor growth is associated with increased hypoxia in BM niche. We have previously demonstrated that activation of Notch signaling could be one of the mechanisms responsible for survival of multiple myeloma (MM) cells from chemotherapeutic drugs. Here we investigated whether hypoxia could modulate Notch signaling and induce chemoresistance of MM cells. Three MM cell lines were treated with doxorubicin or melphalan in hypoxic (1% O2) or normoxic conditions. Using Annexin V binding assay we demonstrated that hypoxia induced chemoresistance in only one (H929) cell line studied. This effect was associated with significant up-regulation of expression of Notch target gene Hes1 and its protein level while Hes1 level was unchanged in other two MM cell lines. Inhibition of Hes1 with siRNA canceled the protective effect of hypoxia on MM cells. To further confirm the involvement of Notch pathway in regulation of drug sensitivity, Hes-1 was overexpressed in MM cells in normoxic condition using vector pIRES-AcGFP-Hes-1. MM cells with increased Hes1 level became less sensitive to chemotherapeutics as compared to cells transfected with control vector. Hes-1 is considered to be a Notch target gene. However, hypoxia did not affect Notch receptors expression level in MM cells. The effect of hypoxia on Hes1 was Notch-independent as was evident from Notch/CBF1 reporter assay. In addition, inhibition of Notch receptor cleavage with gamma-secretase inhibitor GSI-XII (Calbiochem) did not affect hypoxia induced MM cell chemoresistance. Up-regulation of Hes-1 was induced by HIF-1a as treatment of MM cells with hypoxia mimetic deferoxamine resulted in up-regulation of Hes1 and inhibition of HIF-1a with siRNA abrogated hypoxia-induced protection of MM cells. Thus, our study, for the first time, demonstrates that hypoxia could induce chemoresistance of MM cells through Notch-independent up-regulation of Hes-1. These results could be important not only for understanding the cancer biology but for designing therapeutic intervention in MM. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1534. doi:1538-7445.AM2012-1534
Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles
Authors: M G Loudin, J Wang, H-C Eastwood Leung, S Gurusiddappa, J Meyer, G Condos, D Morrison, A Tsimelzon, M Devidas, N A Heerema, A J Carroll, S E Plon, S P Hunger, G Basso, A Pession, D Bhojwani, W L Carroll, K R Rabin
Journal: Leukemia (2011)
A CASE OF HOLOGYNIC INHERITANCE OF ICHTHYOSIS VULGARIS
Authors: TWISTON DAVIES, DONALD McGREGOR
Journal: British Journal of Dermatology (1942)

Journal Article A CASE OF HOLOGYNIC INHERITANCE OF ICHTHYOSIS VULGARIS Get access TWISTON DAVIES, TWISTON DAVIES Search for other works by this author on: Oxford Academic Google Scholar DONALD McGREGOR DONALD McGREGOR Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 54, Issue 4, 1 April 1942, Pages 121–122, https://doi.org/10.1111/j.1365-2133.1942.tb10623.x Published: 01 April 1942