Neonatal Tetany
Authors: PETER HUTGHIN
Journal: Annals of Internal Medicine (1964)

Case Studies1 December 1964Neonatal TetanyDiagnostic Lead to Hyperparathyroidism in the MotherPETER HUTGHIN, M.D., DAVID M. KESSNER, M.D.PETER HUTGHIN, M.D., DAVID M. KESSNER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-6-1109 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince Von Recklinghausen's description of generalized osteitis fibrosa cystica, the clinical manifestations of hyperparathyroidism have undergone an apparent change. After early recognition of the renal complications of the disease (1), a variety of other manifestations of primary hyperparathyroidism were noted, including peptic ulcer (2), pancreatitis (3), multiple endocrine adenomata (4), pitressin resistant diabetes insipidus (5), and various psychologic manifestations (6). Patients with a classical picture of bone or renal disease have gradually become less common, whereas patients without these characteristic findings have been diagnosed more frequently (7). Indeed, in some the diagnosis has been arrived at only by serendipity (8)....References1. ALBRIGHTBAIRDCOPEBLOOMBERG FPCOE: Studies on the physiology of the parathyroid glands. IV. Renal complications of hyperparathyroidism. Amer. J. Med. Sci. 187: 49, 1934. CrossrefGoogle Scholar2. KIRSNER JB: The parathyroids and peptic ulcer. Gastroenterologia 34: 145, 1958. CrossrefGoogle Scholar3. COPECULVERMEXTERNARDIN OPJCGGL: Pancreatitis, a diagnostic clue to hyperparathyroidism. Ann. Surg. 145: 857, 1957. CrossrefMedlineGoogle Scholar4. UNDERDAHLWOOLNERBLACK LOLBBM: Multiple endocrine adenomas. J. Clin. Endocr. 13: 20, 1953. CrossrefMedlineGoogle Scholar5. ALDIS AS: Clinical experiences of lesser known manifestations of hyperparathyroidism. Proc. Roy. Soc. Med. 54: 489, 1961. 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BAKWIN H: Tetany in newborn infants: relation to physiologic hypoparathyroidism. J. Pediat. 14: 1, 1939. CrossrefGoogle Scholar28. CONNELLYCRAWFORDWATSON JPJDJ: Studies of neonatal hyperphosphatemia. Pediatrics 30: 425, 1962. MedlineGoogle Scholar29. DODDRAPAPORT KS: Hypocalcemia in the neonatal period. Amer. J. Dis. Child. 78: 537, 1949. CrossrefMedlineGoogle Scholar30. TALBOTSOBELMCARTHURCRAWFORD NBEHJWJD: Functional Endocrinology from Birth Through Adolescence. Harvard University Press, Cambridge, 1952, p. 118. Google Scholar31. VAN ARSDEL PP: Maternal hyperparathyroidism as a cause of neonatal tetany. J. Clin. Endocr. 15: 680, 1955. CrossrefGoogle Scholar32. BUCHS S: Angeborener hypoparathyreoidismus von drei brudern infolge von hyperparathyreoidismus der mutter. Schweiz. Med. Wschr. 91: 660, 1961. Google Scholar33. MCGEOWNFIELD MGCM: Asymptomatic hyperparathyroidism. Lancet 2: 1268, 1960. CrossrefMedlineGoogle Scholar34. DITTMER DS Blood and Other Body Fluids. Edited by Federation of American Society of Experimental Biologists, Washington, D. C., 1961. Google Scholar35. BRUCESTRONG JJA: Maternal hyperparathyroidism and parathyroid deficiency in the child. Quart. J. Med. 24: 307, 1955. MedlineGoogle Scholar36. FRIDRICHSEN C: Tetany in a suckling. Lancet 1: 85, 1939. CrossrefGoogle Scholar37. HUNTERTURNBULL DHM: Hyperparathyroidism: generalized osteitis fibrosa. Brit. J. Surg. 19: 203, 1931. CrossrefGoogle Scholar38. WALTON AJ: Surgical treatment of parathyroid tumours. Ibid., p. 285. Google Scholar39. GARLOCK JH: Differential diagnosis of hyperparathyroidism. Amer. Surg. 108: 347, 1938. Google Scholar40. FROHNERWOLGAMOT RNJC: Primary hyperparathyroidism: five cases in one family. Ann. Intern. Med. 40: 765, 1954. LinkGoogle Scholar41. LEHRKRUKOWSKI DM: Protection by pregnancy against the sequelae of acute hyperparathyroidism. Naunyn Schmiedeberg Arch. Exp. Path. 242: 143, 1961. CrossrefGoogle Scholar42. PETITCLARK DWRL: Hyperparathyroidism and pregnancy. Amer. J. Surg. 74: 860, 1947. CrossrefMedlineGoogle Scholar43. WHALLEY PJ: Hyperparathyroidism and pregnancy. Amer. J. Obstet. Gynec. 86: 517, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Haven, ConnecticutFrom the Departments of Surgery and Medicine, Yale University School of Medicine, New Haven, Conn.Requests for reprints should be addressed to David Kessner, M.D., Department of Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, Conn. 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