tbuckley/cabot-search huggingface dataset:
Elderly patients in the accident department and their problems.
Authors: A F Dove, S H Dave
Journal: BMJ (1986)

During two months in the winter and two in the summer information was gleaned about all patients aged 70 and over attending a large accident and emergency department. Comparative figures for the same periods over the previous 20 years showed an increasing number of elderly attenders, the increase being closely related to the increasing proportion of elderly in the population. Using national census data, attendance rates were shown to increase dramatically with age. With increasing age more elderly attended as a result of accidents in the home. The information suggested that social isolation and paucity of support in the community may be responsible for the decision to come to hospital rather than to consult the general practitioner. The elderly attend accident and emergency departments for a wide range of problems but some do so solely for socioeconomic reasons and are particularly difficult to help.
Misrepresentation of Academic Accomplishments by Applicants for Gastroenterology Fellowships
Authors: Gail Sekas, William R. Hutson
Journal: Annals of Internal Medicine (1995)

To determine whether two applicants who misrepresented their accomplishments in applications for gastroenterology fellowships reflected isolated incidents or whether misrepresentation was more wide-spread.Retrospective review of all 236 applications submitted for fellowship in a recent year for confirmation of research experience and cited publications.138 applicants (58.5%) reported research experience during residency in a U.S. training program. Research activity could not be confirmed for 47 of 138 applicants (34.1%). Fifty-three applicants (22.4%) reported published articles, and 16 of these applicants (30.2%) misrepresented articles. Misrepresentation included citations of nonexistent articles in actual journals, articles in nonexistent journals, or articles noted as "in press."Misrepresentation on applications for gastroenterology fellowships was common. The following steps are recommended: 1) Fellowship programs should require that copies of all publications and letters of acceptance for manuscripts in press be submitted with fellowship applications; 2) applications should contain a statement to be signed by the applicant that the information provided is accurate; 3) persons writing letters of recommendation should verify the information being submitted by applicants; 4) medical students and residents should be taught that embellishment of curricula vitae constitutes misconduct; and 5) institutions and professional organizations should develop policies to deal with this problem.
Background Mutation Frequency in Microsatellite-Unstable Colorectal Cancer
Authors: Heli Sammalkorpi, Pia Alhopuro, Rainer Lehtonen, Jarno Tuimala, Jukka-Pekka Mecklin, Heikki J. Järvinen, Josef Jiricny, Auli Karhu, Lauri A. Aaltonen
Journal: Cancer Research (2007)

Abstract Microsatellite instability (MSI) is observed in ∼12% of colorectal cancers. Genes containing a mononucleotide microsatellite in the coding sequence are particularly prone to inactivation in MSI tumorigenesis, and much work has been conducted to identify genes with high repetitive tract mutation rates in these tumors. Much less attention has been paid to background mutation frequencies, and no work has focused on nontranscribed regions. Here, we studied 114 nontranscribed intergenic A/T and C/G repeats 6 to 10 bp in length, located distant from known genes, to examine background mutation frequencies in MSI colorectal cancers. A strong correlation with tract length was observed, and mutation frequencies of up to 87% were observed in 8 to 10 bp tracts. Subsequently, to compare the background mutation rate in transcribed and nontranscribed noncoding repeats, we screened nine randomly selected intronic C/G8 repeats. In addition, the coding repeats of seven suggested MSI target genes, and nine previously published intronic A8 and G8 repeats were analyzed. Intronic repeats seemed to mutate less frequently than nontranscribed intergenic repeats. Our results show that strand slippage mutations in mismatch repair–deficient cells are as abundant in short intergenic repeats as in many proposed MSI target genes. However, under mismatch repair deficiency, strand slippage mutations in transcribed sequences seem to be repaired more efficiently than in intergenic nontranscribed sequences. The mechanisms causing these differences are not yet understood and should be a subject for further studies. For MSI target gene identification, repeats in transcribed sequences seem to be the most appropriate reference group for coding region repeat mutations. [Cancer Res 2007;67(12):5691–8]
Pediatric severe asthma is characterized by eosinophilia and remodeling without TH2 cytokines
Authors: Cara J. Bossley, Louise Fleming, Atul Gupta, Nicolas Regamey, Jennifer Frith, Timothy Oates, Lemonia Tsartsali, Clare M. Lloyd, Andrew Bush, Sejal Saglani
Journal: Journal of Allergy and Clinical Immunology (2012)
Suprofen and Renal Failure
Authors: SAMUEL SNYDER
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 May 1987Suprofen and Renal FailureSAMUEL SNYDER, D.O., BRENDAN P. TEEHAN, M.D.SAMUEL SNYDER, D.O.Search for more papers by this author, BRENDAN P. TEEHAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-5-776_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Hart and associates (1) report a syndrome of mild reversible renal failure caused by suprofen, but did not determine a pathogenetic mechanism. The following case, characteristic of the described syndrome, was diagnosed as allergic interstitial nephritis.A 27-year-old white man presented with a 1-day history of dull mid-back and flank pain, dysuria, tea-colored urine, and chills. Medical history included crush injuries of both lower extremities 6 years ago, for which he still required aspirin and acetominophen with codeine on a daily basis. In the 24 to 36 hours before admission, he took two doses of suprofen for...Reference1. HARTWARDLIFSCHITZ DMM. Suprofen-related nephrotoxicity: a distinct clinical syndrome. Ann Intern Med. 1987;106:235-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Lankenau Hospital Philadelphia, PA 19151 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIn-Vitro Approaches to Predict and Study T-Cell Mediated Hypersensitivity to DrugsTime-dependent CYP inhibitionNabumetone-Associated Interstitial NephritisDrugs and the KidneyAnti-inflammatory analgesics and drugs used in rheumatoid arthritis and gout 1 May 1987Volume 106, Issue 5Page: 776-776KeywordsAspirinCodeineNephritisPathogensRenal failureUrine Issue Published: 1 May 1987 PDF DownloadLoading ...
p53-dependent regulation of heat shock protein 72
Authors: L.A. Quenneville, M.J. Trotter, T. Maeda, V.A. Tron
Journal: British Journal of Dermatology (2002)

Summary Background p53 is a key regulator of the cellular stress response. p53 modulates the transcription of several genes. Objectives To examine the influence of p53 on expression of heat shock protein 72 (HSP72). Methods Two model systems were used. (i) HSP72 expression was studied by Western blot on extracts from p53-proficient or p53-deficient primary mouse keratinocytes, and (ii) archival human anogenital skin from fibroepithelial polyps, human papillomavirus (HPV) 16/18-associated lesions or squamous cell carcinomas (SCCs) was subjected to immunostaining for HSP72. Results Basal HSP72 expression was higher in keratinocytes from p53-deficient than from p53-proficient mice. Immunostaining for HSP72 was higher in HPV 16/18 lesions and SCCs, which have reduced p53 protein. Conclusions p53 status may influence the basal level of HSP72.
Pathoanatomic, Pathophysiologic and Clinical Correlations in Endocarditis
Authors: Howard L. Bleich, Emily S. Boro, Louis Weinstein, Jacob J Schlesinger
Journal: New England Journal of Medicine (1974)

A TRUE understanding of disease demands thorough knowledge of the specific pathophysiologic and pathoanatomic processes involved, It is interesting, in this regard, that in only a few of the numerous disorders that affect human beings are the responsible mechanisms sufficiently defined to permit prediction of the clinical pictures. For example, the clinical syndromes and pathological changes associated with atherosclerosis are well known, but the mechanisms involved in their pathogenesis are still matters for debate. Similarly, it is still not clear what occurs in the patient overwhelmed by the staphylococcus, nor are the anatomic and physiologic bases for the symptoms produced . . .
Diagnosis and Treatment of Depression in Adults With Comorbid Medical Conditions
Authors: Mary A. Whooley
Journal: JAMA (2012)

Approximately 1 in 10 primary care patients has major depressive disorder, and its presence is associated with poor health outcomes in numerous medical conditions. Using the case of Mr J, a 52-year-old man with depressive symptoms and several comorbid medical conditions, diagnosis and treatment of depression are discussed. Specific topics include evidence regarding appropriate depression screening and diagnosis, the importance of team-based care, patient self-management, exercise, structured psychotherapy, pharmacotherapy, monitoring of therapy, and indications for referral.
EXERCISE STRESS TEST RESULTS IN PATIENTS WITH BARE METAL STENTS OR DRUG ELUTING STENTS: PATHOPHYSIOLOGICAL AND CLINICAL IMPLICATIONS
Authors: Gaetano A. Lanza, Roberto Nerla, Antonio Di Monaco, Gaetano Pinnacchio, Roberto Mollo, Cristina Aurigemma, Gregory A. Sgueglia, Alfonso Sestito, Filippo Crea
Journal: Journal of the American College of Cardiology (2010)
The Impact of Macrophage- and Microglia-Secreted TNFα on Oncolytic HSV-1 Therapy in the Glioblastoma Tumor Microenvironment
Authors: W. Hans Meisen, Eric S. Wohleb, Alena Cristina Jaime-Ramirez, Chelsea Bolyard, Ji Young Yoo, Luke Russell, Jayson Hardcastle, Samuel Dubin, Kamaldeen Muili, Jianhua Yu, Michael Caligiuri, Jonathan Godbout, Balveen Kaur
Journal: Clinical Cancer Research (2015)

Oncolytic herpes simplex viruses (oHSV) represent a promising therapy for glioblastoma (GBM), but their clinical success has been limited. Early innate immune responses to viral infection reduce oHSV replication, tumor destruction, and efficacy. Here, we characterized the antiviral effects of macrophages and microglia on viral therapy for GBM.Quantitative flow cytometry of mice with intracranial gliomas (±oHSV) was used to examine macrophage/microglia infiltration and activation. In vitro coculture assays of infected glioma cells with microglia/macrophages were used to test their impact on oHSV replication. Macrophages from TNFα-knockout mice and blocking antibodies were used to evaluate the biologic effects of TNFα on virus replication. TNFα blocking antibodies were used to evaluate the impact of TNFα on oHSV therapy in vivo.Flow-cytometry analysis revealed a 7.9-fold increase in macrophage infiltration after virus treatment. Tumor-infiltrating macrophages/microglia were polarized toward a M1, proinflammatory phenotype, and they expressed high levels of CD86, MHCII, and Ly6C. Macrophages/microglia produced significant amounts of TNFα in response to infected glioma cells in vitro and in vivo. Using TNFα-blocking antibodies and macrophages derived from TNFα-knockout mice, we discovered TNFα-induced apoptosis in infected tumor cells and inhibited virus replication. Finally, we demonstrated the transient blockade of TNFα from the tumor microenvironment with TNFα-blocking antibodies significantly enhanced virus replication and survival in GBM intracranial tumors.The results of these studies suggest that FDA approved TNFα inhibitors may significantly improve the efficacy of oncolytic virus therapy.
Gene expression of Na+/Ca2+ exchanger during development in human heart
Authors: Y Qu
Journal: Cardiovascular Research (2000)

Objective: In immature animal hearts, lower activity of sarcoplasmic reticulum and lower densities of Ca2+ channels highlight the potentially vital role of the Na+/Ca2+ exchanger (NCX) to excitation–contraction coupling. To date, studies on NCX expression have been restricted to late developmental stages. The distribution and gene expression of NCX during early ontogeny is not known, especially in humans. In the present report, we systematically characterized changes in NCX gene expression in human heart during development, with particular emphasis in early ontogeny. Methods: Human hearts during early gestation (9- to 20-week gestation), neonatal (1 to 2 days after birth) and adulthood (18–40 years old) were used. NCX mRNA levels were studied using RNase Protection Assay (RPA) and NCX protein levels were assessed by Western blot. Wet weight was also used as the tissue base. Immunolocalization studies using confocal microscopy were performed in isolated fetal cardiac myocytes. Results: Normalization of NCX mRNA derived from ventricles against an early gestational age (10-week gestation) shows that NCX mRNA levels nominally increased from 1 to 1.13 at 19-week gestation then decreased to 0.74 (P<0.05) at neonate and further decreased to 0.23 (P<0.05) at adult stages. NCX protein levels increased from 1 at 9-week gestation to 3 (P<0.05) at 20-week gestation and then decreased to 1.8 (P<0.05) at neonate and to 1.87 (P<0.05) at adult stages. Confocal imaging of fetal cardiac myocytes revealed intense homogeneous membrane staining and abundance of NCX protein at this stage. Conclusions: The data demonstrate changes in NCX transcript and NCX protein levels as well as total RNA and proteins during human heart development. Per wet weight, NCX mRNA was 4.5 times greater at early fetal than adult stages and NCX protein was 2 times greater at adult than the early fetal stage indicating considerable post-transcriptional regulation. These findings provide new insights into the understanding of temporal changes in NCX in the developing heart at the gene level. The functional significance remains to be determined.
Combination Therapy With Abciximab Reduces Angiographically Evident Thrombus in Acute Myocardial Infarction
Authors: C. Michael Gibson, James A. de Lemos, Sabina A. Murphy, Susan J. Marble, Carolyn H. McCabe, Christopher P. Cannon, Elliott M. Antman, Eugene Braunwald
Journal: Circulation (2001)

Background —Use of abciximab in combination with administration of thrombolytics has been shown to improve epicardial and microvascular coronary blood flow in acute myocardial infarction (AMI). As a potential mechanism, we hypothesized that combination therapy would reduce angiographically evident thrombus (AET) and would increase lumen diameter compared with thrombolytic monotherapy. Methods and Results —Patients who received combination therapy in TIMI 14 (low-dose thrombolytic plus abciximab, n=732) were compared with patients who received thrombolytic monotherapy without abciximab in the TIMI 4, 10A, 10B, and 14 trials (n=1662). Thrombus burden was assessed 90 minutes after treatment, and quantitative angiography was performed in an angiographic core laboratory by investigators blinded to treatment assignment. The frequency of AET was reduced in patients who received abciximab combination therapy compared with thrombolytic monotherapy (26.6% versus 35.4%, P &lt;0.001). Similar findings were observed when the analysis was restricted to patients with patent arteries (14.7% versus 20.8%, P =0.001). Residual percent diameter stenosis at 90 minutes was also improved in the abciximab therapy group both in patent arteries (64.6±16.6 versus 68.3±14.8, P &lt;0.001) and between patent and occluded arteries (69.3±19.5 versus 73.8±17.9, P &lt;0.001). The absence of AET was associated with an increased frequency of &gt;70% ST-segment resolution by 90 minutes (37.2%, 110/296 versus 18.9%, 54/286, P &lt;0.001). Conclusions —Compared with thrombolytic monotherapy, combination therapy with abciximab reduces AET, which in turn is associated with reduced residual stenosis and improved ST-segment resolution in AMI. These data provide a pathophysiological link between platelet inhibition, reduced thrombus, and improvements in both epicardial and microvascular perfusion in AMI.
Best books on paediatrics: a personal choice
Authors: M. Rosenthal
Journal: BMJ (1996)

Trying to write an article on the best books in paediatrics is like trying to summarise Proust: the harder you try, the worse it gets. This article does not tell you what to buy but aims at getting you to open the books so that you can come to your own conclusions.

∗∗∗ Essential Paediatrics. 3rd edn. D I Johnston, D Hull. (£24.95.) Churchill Livingstone, 1993. ISBN 0 443 04782 0.

∗∗ Child Health: A Textbook for the DCH. 2nd edn. Ed D Harvey, I Kovar. (£50.) Churchill Livingstone, 1991. ISBN 0 443 04026 5.

∗∗ Jolly's Diseases of Children. 2nd edn. Ed M I Levene. ((pounds stering)49.50.) Blackwell Scientific, 1991 ISBN 0 632 02723 1.

Essential Paediatrics is the standard British undergraduate textbook. Nearly perfect for a first paediatric student attachment, it is well laid out with pretty pencil drawings and thumbnail sketches of physiology, but the neonatal section is too brief. Child Health: A Textbook for the DCH seems to cover everything that a reasonable person would be expected to know at finals. Word based rather than table and picture based, it is now four years old and does not have enough …
Heritability of Left Ventricular Mass and Other Morphologic Variables in Caribbean Hispanic Subjects: The Northern Manhattan Family Study
Authors: Suh-Hang Hank Juo, Marco R. Di Tullio, Hsiu-Fen Lin, Tanja Rundek, Bernadette Boden-Albala, Shunichi Homma, Ralph L. Sacco
Journal: Journal of the American College of Cardiology (2005)
350 My of Mitochondrial Genome Stasis in Mosses, an Early Land Plant Lineage
Authors: Yang Liu, Rafael Medina, Bernard Goffinet
Journal: Molecular Biology and Evolution (2014)

Among land plants, angiosperms have the structurally most labile mitochondrial (mt) genomes. In contrast, the so-called early land plants (e.g., mosses) seem to have completely static mt chromosomes. We assembled the complete mt genomes from 12 mosses spanning the moss tree of life, to assess 1) the phylogenetic depth of the conserved mt gene content and order and 2) the correlation between scattered sequence repeats and gene order lability in land plants. The mt genome of most mosses is approximately 100 kb in size, and thereby the smallest among land plants. Based on divergence time estimates, moss mt genome structure has remained virtually frozen for 350 My, with only two independent gene losses and a single gene relocation detected across the macroevolutionary tree. This is the longest period of mt genome stasis demonstrated to date in a plant lineage. The complete lack of intergenic repeat sequences, considered to be essential for intragenomic recombinations, likely accounts for the evolutionary stability of moss mt genomes.
Cigarettes, Ulcerative Colitis, and Inferences from Uncontrolled Data
Authors: John C. Bailar
Journal: New England Journal of Medicine (1983)

The myriad components of cigarette smoke include some potent toxic and pharmacologic agents. Of those whose effects are known, most are unequivocally bad.1 That is no reason, however, to assume a priori that all the effects must be bad, and indeed an apparent beneficial effect on Parkinsonism was reported many years ago.2 In this issue of the Journal, Jick and Walker3 report a statistically significant negative association between cigarette smoking and ulcerative colitis, and they cite several earlier and more limited reports of the same relation. What should we make of this? Four possibilities come to mind: the observed . . .
Endoscopic ultrasound diagnosis of a small splenic vein aneurysm
Authors: Keishi Komori, Kazuya Akahoshi, Yasuaki Motomura, Masaru Kubokawa, Junya Gibo, Kenji Kanayama, Shinichiro Fukuda, Shohei Hamada, Yoshiaki Otuka, Kazuhiko Nakamura
Journal: Endoscopy (2014)

Splenic vein aneurysm (SVA) is an extremely rare vascular abnormality. Although endoscopic ultrasound (EUS) can detect vascular structures, the characteristic findings of an SVA have not been reported. We describe a patient with an SVA found incidentally on an EUS that was performed for gastric antral ectopic pancreas. The diagnosis was based on the findings during EUS using an electronic radial scanning echoendoscope (EG-530UR; Fujifilm Corp., Saitama, Japan) with color Doppler flow-mapping capabilities.
The presence of anti-basement membrane zone antibodies in the sera of patients with non-bullous lupus erythematosus
Authors: O. ISHIKAWA, K.K. ZAW, Y. MIYACHI, T. HASHIMOTO, T. TANAKA
Journal: British Journal of Dermatology (1997)

We performed indirect immunofluorescence (IF) studies using 1 mol/l sodium chloride split skin to determine whether or not a positive IF is specific to patients with bullous lupus erythematosus (LE). We examined the sera from 21 patients with systemic LE (SLE), three of which were obtained from two SLE patients and one subacute cutaneous LE (SCLE) patient with bullous eruptions. As a comparison, we also studied the sera from patients with discoid LE (DLE, n = 7), SCLE (n = 1), systemic sclerosis (SSc, n = 20), bullous pemphigoid (n = 2) and normal individuals (n = 10). Sera from 16 SLE, four DLE and two SSc revealed a linear deposition of IgG isotype antibody at the epidermal side and/or the dermal side on indirect IF of split skin. The sera from three patients with bullous eruption and from 12 patients of SLE, SCLE, DLE without bullous eruption or SSc were further analysed by immunoblotting using five defined antigens, i.e. dermal extract, epidermal extract, three fusion proteins of 230 kDa bullous pemphigoid antigen (BPAG). 180 kDa BPAG, and human epidermolysis bullosa acquisita (EBA) antigen. Two SLE sera as well as one of the SCLE and the DLE serum reacted with 230 kDa BPAG in epidermal extract, and one of the SCLE and the DLE serum also reacted with the fusion protein of 180 kDa BPAG. No serum reacted with the dermal extract or the fusion protein of 230 kDa BPAG or EBA antigen. There was no consistent correlation between split-skin IF results and immunoblotting results. These results may suggest that even non-bullous LE patients often have autoantibodies to the basement membrane zone antigens, most of which are less pathogenic. Although we rarely examine the sera from non-bullous LE patients, we should keep this phenomenon in mind to avoid overestimating the results of split-skin test and immunoblotting.
Current concepts in contact dermatitis
Authors: J. English
Journal: British Journal of Dermatology (2001)

Journal Article Current concepts in contact dermatitis Get access J. English J. English Department of Dermatology, Queen's Medical Centre, University Hospital, Nottingham NG7 2LM, U.K. E‐mail: john.english@mail.qmcuh‐tr.trent.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 4, 1 October 2001, Pages 527–529, https://doi.org/10.1046/j.1365-2133.2001.04441.x Published: 01 October 2001
73 PANCREATIC DUODENAL HOMEOBOX GENE-1 (PDX-1) PROTEIN DE NOVO EXPRESSION IN REACTIVE CHOLANGIOCYTES DRIVES THEIR PHENOTYPICAL CHANGES IN RESPONSE TO INJURY
Authors: M. Marzioni, S. Saccomanno, C. Candelaresi, C. Rychlicki, L. Agostinelli, K. Shanmukhappa, L. Trozzi, S. De Minicis, A. Benedetti
Journal: Journal of Hepatology (2009)