tbuckley/cabot-search huggingface dataset:
Intracellular and extracellular recordings of sinus node activity: comparison with estimated sinoatrial conduction times during pacemaker shifts in rabbit heart
Authors: J.-Y. L. HEUZEY, L. GUIZE, J. VALTY, J.-P. MOUTET, S. KOUZ, T. LAVERGNE, M. BOUTJDIR, P. PERONNEAU
Journal: Cardiovascular Research (1986)

Journal Article Intracellular and extracellular recordings of sinus node activity: comparison with estimated sinoatrial conduction times during pacemaker shifts in rabbit heart Get access JEAN-YVES LE HEUZEY, JEAN-YVES LE HEUZEY **From the Divisions of Cardiology, Broussais and Saint Antoine Hospitals, Pierre and Marie Curie University, Paris, France†From the INSERM U 256 Laboratory, Broussais and Saint Antoine Hospitals, Pierre and Marie Curie University, Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar LOUIS GUIZE, LOUIS GUIZE **From the Divisions of Cardiology, Broussais and Saint Antoine Hospitals, Pierre and Marie Curie University, Paris, France†From the INSERM U 256 Laboratory, Broussais and Saint Antoine Hospitals, Pierre and Marie Curie University, Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar JEAN VALTY, JEAN VALTY **From the Divisions of Cardiology, Broussais and Saint Antoine Hospitals, Pierre and Marie Curie University, Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar JEAN-PAUL MOUTET, JEAN-PAUL MOUTET †From the INSERM U 256 Laboratory, Broussais and Saint Antoine Hospitals, Pierre and Marie Curie University, Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar SIMON KOUZ, SIMON KOUZ **From the Divisions of Cardiology, Broussais and Saint Antoine Hospitals, Pierre and Marie Curie University, Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar THOMAS LAVERGNE, THOMAS LAVERGNE †From the INSERM U 256 Laboratory, Broussais and Saint Antoine Hospitals, Pierre and Marie Curie University, Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar MOHAMED BOUTJDIR, MOHAMED BOUTJDIR †From the INSERM U 256 Laboratory, Broussais and Saint Antoine Hospitals, Pierre and Marie Curie University, Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar PIERRE PERONNEAU PIERRE PERONNEAU †From the INSERM U 256 Laboratory, Broussais and Saint Antoine Hospitals, Pierre and Marie Curie University, Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 20, Issue 2, February 1986, Pages 81–88, https://doi.org/10.1093/cvr/20.2.81 Published: 01 February 1986
Constraining solution space to improve generalization
Authors: John A. Bullinaria
Journal: Behavioral and Brain Sciences (1997)

I suggest that the difficulties inherent in discovering the hidden regularities in realistic (type-2) problems can often be resolved by learning algorithms employing simple constraints (such as symmetry and the importance of local information) that are natural from an evolutionary point of view. Neither “heavy-duty nativism” nor “representational recoding” appear to offer totally appropriate descriptions of such natural learning processes.
Allogeneic Stem-Cell Transplantation of Renal Cell Cancer After Nonmyeloablative Chemotherapy: Feasibility, Engraftment, and Clinical Results
Authors: Brian I. Rini, Todd Zimmerman, Walter M. Stadler, Thomas F. Gajewski, Nicholas J. Vogelzang
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To evaluate the feasibility and safety of nonmyeloablative allogeneic stem-cell transplantation in patients with metastatic renal cell cancer (RCC) and to evaluate efficacy with respect to engraftment and tumor regression. PATIENTS AND METHODS: Between February 1999 and June 2001, patients with refractory, metastatic RCC were screened for enrollment. A fludarabine and cyclophosphamide–based conditioning regimen was used. Patients received granulocyte-macrophage colony-stimulating factor–mobilized, unmanipulated stem cells from a 6/6 HLA-matched sibling donor. Prophylaxis against graft rejection and graft-versus-host disease (GVHD) included tacrolimus and mycophenolate mofetil. RESULTS: A total of 284 patients with metastatic RCC were seen during this time period. Eighty-four patients who had siblings available for HLA typing were actively screened for enrollment, and 15 patients have undergone treatment. Durable donor engraftment was achieved in one of the first four patients treated. Patients no. 5 through 15 received a more immunosuppressive conditioning regimen, and all have achieved sustained donor engraftment. In the 12 patients with at least 180 days of follow-up, acute GVHD has occurred in two patients and chronic GVHD in six patients, with four transplant-related mortalities. Four partial responses have been observed (response rate, 33% in all patients; 44% in the nine patients with sustained donor engraftment). CONCLUSION: Nonmyeloablative allogeneic stem-cell transplantation is feasible for a minority of patients with metastatic RCC. Adequately immunosuppressive conditioning is required for sustained donor engraftment, which is required for an antitumor response. Acute and chronic GVHD are the major causes of substantial morbidity and mortality. Metastatic RCC is susceptible to a graft-versus-tumor effect promoted by allogeneic stem-cell transplantation.
William Sydney Charles Copeman C.B.E., T.D., M.A., M.D., F.R.C.P., 1900-1970.
Authors: O Savage
Journal: Annals of the Rheumatic Diseases (1971)

As one of the editors of the Annals of the Rheumatic Diseases from its inception, William Copeman played a leading part in guiding its growth until it became one of the foremost journals concerned with rheumatic diseases with a steadily increasing world-wide circulation.Born in 1900, the son of a distinguished doctor and descended from a line of famous physicians, he was educated at Lancing, Caius College, Cambridge, and St. Thomas's Hospital.After a medical registrarship at St. Mary's he was appointed physician to the Children's Department of the West London Hospital.But he soon
Positive patch tests to Euro coins in nickel-sensitized patients
Authors: E. Nucera, D. Schiavino, A. Calandrelli, C. Roncallo, A. Buonomo, C. Pedone, C. Lombardo, V. Pecora, T. De Pasquale, E. Pollastrini, G. Patriarca
Journal: British Journal of Dermatology (2004)

Many efforts have been made to prevent nickel allergy, the most frequent contact allergy in industrialized countries, by identifying acceptable limits of exposure. Even though coins are not covered by the EU Nickel Directive, some authors suggest that nickel release from coins during handling may elicit contact dermatitis in nickel-allergic people.To evaluate sensitivity to nickel released from coins in nickel-allergic patients and to verify whether nickel release from the new Euro coins may elicit stronger cutaneous reactivity than from old Italian lire coins.Twenty-five nickel-allergic patients were patch tested with 1- and 2-Euro coins, 1-, 2- and 50-Euro cent coins, and 100 and 500 Italian lire coins. Ten healthy nonnickel-allergic control individuals were also tested.Nineteen patients had positive patch tests to 1- and 2-Euro coins. One was also positive to 1- and 2-Euro cent coins, four to 50-Euro cent coins, and 13 to the 500-lire coin. None had a positive patch test to the 100-lire coin. The number and degree of positive patch tests to coins were related to nickel content.Euro coins may be potentially more dangerous than old Italian coins. Coins containing little or no nickel should be chosen for coinage to prevent sensitization and to avoid exacerbation of contact dermatitis in nickel-allergic patients.
Clonorchiasis in San Francisco
Authors: Walter G. Strauss
Journal: JAMA (1962)

CLONORCHIASIS is endemic in China, Korea, Japan, and Formosa. San Francisco, being a strategic center in commerce with the Far East, probably has the largest colony of patients with clonorchiasis outside the Orient. This study describes factors pertinent to an understanding of the disease in an extra-Oriental setting. <i>History.</i>—On Sept. 9, 1874, McConnell in Calcutta performed an autopsy on a Chinese man and discovered that the bile ducts were swarming with live flukes. His report in 1875 is the first describing the disease in humans. In 1888 Biggs, who was pathologist at New York's Bellevue Hospital, had a similar experience and discovered the first case of clonorchiasis in the United States. The disease was recognized in San Francisco in 1901 when White found flukes in 18 Chinese dead of plague. The flukes have a tenacious hold on life, and when found at postmortem examination are usually alive. But White found
875. Adenoviral Vector Targeting – New Targets for Old Capsids
Authors: Douglas E. Brough, Hinrich Staecker, Masaki Akiyama, Chi Hsu, Selva R. Murugesan, David A. Einfeld, Jason G. Gall, Lisa L. Wei, Melissa Hamilton, Duncan McVey, C. Richter King
Journal: Molecular Therapy (2005)

Top of pageAbstract
The goal of our adenoviral vector-targeting program is to identify strategies that enhance delivery of therapeutic proteins to the site of disease as well as reduce the impact of the therapy on nontarget cells and tissue. Therapeutic areas under consideration are cancer, ocular disease, vaccine, hearing loss and balance disorders. To accomplish this we have created vectors that are ablated for binding to native CAR and integrin receptors, have introduced specific binding ligands for selective entry into the cells of choice, and have evaluated vector performance in these target therapeutic areas. We have evaluated the pharmacokinetics and biodistribution of tropism-modified vectors in regional (intra-peritoneal) and disseminated cancer disease models and have shown the importance of selective delivery to tumors after regional and systemic administration. Delivery to the eye and ear of tropism-modified vectors results in transduction of new target cells and the modifications may also impact the kinetics of transgene expression. We have demonstrated low-level expression of the normal entry receptors for adenovirus in the inner ear of mice, which is inconsistent with the amount of gene delivery observed by native tropism vectors. Adenovirus capsids ablated of normal receptor interactions (CAR and integrin) are still capable of gene delivery, suggesting that vector entry may occur through alternative pathways. The efficiency of gene delivery in the inner ear by capsid-modified vectors is dependent on target volume and local vector concentration. While efficient delivery within the inner ear is retained by the ablated vector, it has a restricted tropism for gene delivery to tissue outside of the inner ear. These results collectively lend support to the design of targeted adenovirus vectors that could enhance the delivery of the therapeutic protein and thereby be used for multiple clinical applications.
PROGNOSIS IN INDUSTRIAL DERMATITIS
Authors: D. BURROWS
Journal: British Journal of Dermatology (1972)

Summary.— One hundred and thirteen patients with industrial dermatitis were reviewed 10–13 years later. Seventy‐nine per cent still required treatment from time to time. Cement dermatitis had a significant worse prognosis than oil dermatitis. Only 8 of cases of cement dermatitis were clear. In a review of cases for which industrial injuries benefit is paid in Northern Ireland there were about 150 successful claims for contact dermatitis per year this being about 1 of all industrial injuries occurring in a working population of 500,000. The incidence of dermatitis diminishes with age, but the risk has been reduced by only about 50 in the older age group 55–64 compared with the younger age group 25–34.
CD8<sup>+</sup> T Cell Subsets and Chronic Obstructive Pulmonary Disease
Authors: DAVID M. KEMENY, BEEJAL VYAS, MILICA VUKMANOVIC-STEJIC, MATTHEW J. THOMAS, ALISTAIR NOBLE, LI-CHER LOH, BRIAN J. O'CONNOR
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Section:ChooseTop of pageAbstract <<THE DIVISION OF LABOR BET...CD4+ T CELL SUBSETSCD8+ T CELL SUBSETSEFFECTOR FUNCTIONS OF CD8...IMMUNE REGULATION BY CD8+...CD8+ T CELLS IN ASTHMACD8+ T CELLS IN OTHER LUN...FUTURE QUESTIONSReferencesCITING ARTICLES
Humoral and cardiac effects of TIPS in cirrhotic patients with different "effective" blood volume
Authors: Francesco Salerno, Massimo Cazzaniga, Giovanni Pagnozzi, Ilaria Cirello, Antonio Nicolini, Daniele Meregaglia, Larry Burdick
Journal: Hepatology (2003)

The aim of this study was to evaluate the cardiac effects of transjugular intrahepatic portosystemic shunts (TIPS) in cirrhotic patients with different effective blood volume. Two-dimensional echocardiography was performed before and 7 and 28 days after TIPS insertion in 7 cirrhotic patients with PRA <4 ng/mL/h (group A, normal effective blood volume) and 15 with PRA >4 ng/mL/h (group B, reduced effective blood volume). Before TIPS, most cirrhotic patients showed diastolic dysfunction as indicated by reduced early maximal ventricular filling velocity (E)/late filling velocity (A) ratio. Patients of group B differed from patients of group A because of smaller left ventricular volumes and stroke volume, indicating central underfilling. After TIPS insertion, portal decompression was associated with a significant increase of cardiac output (CO) and a decrease of peripheral resistances. The most important changes were recorded in patients of group B, who showed a significant increase of both the end-diastolic left ventricular volumes and the E/A ratio and a significant decrease of PRA. In conclusion, these results show that the hemodynamic effects of TIPS differ according to the pre-TIPS effective blood volume. Furthermore, TIPS improves the diastolic cardiac function of cirrhotic patients with effective hypovolemia. This result is likely due to a TIPS-related improvement of the fullness of central blood volume.
Metabolic Disorders in the Center of Genetic Medicine
Authors: Harvey L. Levy
Journal: New England Journal of Medicine (2005)

Genetics is the new frontier of medicine. Hardly an issue of any leading medical journal is published without one or more articles on a genetic disease or a topic closely related to genetics. A recent series of articles in the Journal was devoted to the importance of genetics in medical practice.1 The immediate impetus for such a series was, as is widely known, the sequencing of the human genome and the promise that that effort would lead to better diagnosis and treatment of disease.2 However, the knowledge that many metabolic disorders are genetic has long been seen as evidence, with . . .
Medical resident's manual.
Authors: Harry A. Bliss
Journal: JAMA (1963)

The physician's manual, that compendium of clinical information, pharmacological data, and laboratory techniques, belongs to no discipline but its own. The species is an inventive one, for new varieties constantly evolve, each attempting to survive in some part of the medical environment as yet unoccupied by one of its fellows. The hardiness of a few of these organisms is attested by the many editions through which they have passed. In competition with standard reference texts, these little volumes possess distinct advantages. Their small size is appealing and the low price permits purchase of the latest edition without serious pain. The breadth and depth of coverage seemingly offered through the use of telegraphic style and numerous tables may give the reader a satisfying sense of having acquired definitive knowledge. Yet brevity here makes oversimplification inevitable. Some of these works, the perennial<i>Merck Manual</i>,<sup>1</sup>for example, provide a remarkable mass of
[ 18 ]F FDG PET/CT imaging to monitor the therapeutic effect of liposome-encapsulated prednisolone in experimental rheumatoid arthritis
Authors: Tessa van der Geest, Josbert M. Metselaar, Danny Gerrits, Peter L. van Lent, Gert Storm, Peter Laverman, Otto C. Boerman
Journal: Journal of Controlled Release (2015)
The contralateral subgaleal sliding flap for the single-stage reconstruction of large defects of the temple and lateral forehead
Authors: W. Hussain
Journal: British Journal of Dermatology (2013)

Due to the relative lack of a mobile tissue reservoir, the flap repair of large defects of the temple and lateral forehead is challenging.To present our experience of the contralateral subgaleal sliding (CLASS) flap for the single-stage aesthetic repair of such defects.Data were collated on all patients at one regional Mohs centre in whom the CLASS flap had been performed since 2011.The CLASS flap was performed on 16 patients (11 male, five female) with an average age of 63 years (range 42-90). The average defect size was 2·8 × 3·1 cm. A single case of postoperative infection occurred, which settled with appropriate therapy with no adverse sequelae. All patients rated their outcome as good or excellent.The CLASS flap is a reliable, aesthetic, single-stage reconstructive technique for large defects of the lateral forehead and temple.
Uses of allopurinol.
Authors: G D Kersley
Journal: BMJ (1971)

Uses of Allopuninol SIR,-With reference to your excellent leading article (23 October, p. 185), I would raise two points.Having followed up a series of gouty patients for 20 years, first on uricosurics and then on allopurinol, I have no doubt in stating that the urinary complications while using the uricosuric drugs make allopurinol the preferable method of treat- ment in any case where it is decided to start long-term treatment.Secondly, from a follow-up of 50 cases, now for over five years,' the dangers of long-term treatment seem to be minimal.Moreover, the return to statu quo on gradually ceasing treatment with allopurinol in the least severe cases is much less rapid than on discontinuing the uricosuric agents.-Iam, etc.,
Hair Manganese and Hyperactive Behaviors: Pilot Study of School-Age Children Exposed through Tap Water
Authors: Maryse Bouchard, François Laforest, Louise Vandelac, David Bellinger, Donna Mergler
Journal: Environmental Health Perspectives (2006)

BackgroundNeurotoxic effects are known to occur with inhalation of manganese particulates, but very few data are available on exposure to Mn in water. We undertook a pilot study in a community in Québec (Canada) where naturally occurring high Mn levels were present in the public water system. Our objective was to test the hypothesis that greater exposure to Mn via drinking water would be reflected in higher Mn content in hair which, in turn, would be associated with increased level of hyperactive behaviors.MethodsForty-six children participated in the study, 24 boys and 22 girls, 6–15 years of age (median, 11 years). Their homes received water from one of two wells (W) with different Mn concentrations: W1: mean 610 μg/L; W2: mean 160 μg/L. The Revised Conners’ Rating Scale for parents (CPRS-R) and for teachers (CTRS-R) were administered, providing T-scores on the following subscales: Oppositional, Hyperactivity, Cognitive Problems/Inattention, and ADHD Index.ResultsChildren whose houses were supplied by W1 had higher hair Mn (MnH) than those supplied by W2 (mean 6.2 ± 4.7 μg/g vs. 3.3 ± 3.0 μg/g, p = 0.025). MnH was significantly associated with T-scores on the CTRS-R Oppositional (p = 0.020) and Hyperactivity (p = 0.002) subscales, after adjustment for age, sex, and income. All children with Oppositional and Hyperactivity T-scores ≥ 65 had MnH &gt; 3.0 μg/g.ConclusionsThe findings of this pilot study are sufficiently compelling to warrant more extensive investigations into the risks of Mn exposure in drinking water.
People actually are about as bad as social psychologists say, or worse
Authors: Michael P. Maratsos
Journal: Behavioral and Brain Sciences (2004)

Experimental studies are not representative of how badly people function. We study people under relatively innocuous conditions, where their self-interests are very low. In the real world, where people's self-interests are much higher, people are much worse a good deal of the time (some illustrations are cited). This is often “adaptive” for the perpetrators, but that doesn't make it “good” behavior. That people function so badly in our experiments, where self-interest is relatively minimal, is what is really terrifying.
Long-Term Metaproterenol Therapy in Asthmatic Children
Authors: Bertram W. Carnow
Journal: JAMA (1976)

<h3>To the Editor.—</h3> In the article by Milan L. Brandon, MD (235:736, 1976), the author cited a study that concluded that this drug was more efficient than a placebo as a bronchodilator and therefore was useful in the treatment of asthmatic children. In his introduction, Dr Brandon also compares the advantage of this drug as a single entity to combination drugs. While I too believe that drug therapy should be individualized and generally believe that drug combinations are undesirable, the comparisons he makes relate to the barbiturates and to the theophylline content—not to the ephedrine. Clinical trials are an important way of establishing the efficacy of drugs. It would have been much more appropriate to compare metaproteranol with the drugs it might replace, ie, isoproterenol and ephedrine. In that way, the relative efficacy of this drug as compared with others could be assessed. The fact that it is better than
Risk of hospital admission for idiopathic venous thromboembolism among users of postmenopausal oestrogens
Authors: Hershel Jick, Laura E Derby, Marian Wald Myers, Catherine Vasilakis, Katherine M Newton
Journal: The Lancet (1996)

Background At the request of researchers in the UK, we conducted a case-control study to explore the relation between use of postmenopausal oestrogen hormone replacement therapy (HRT) and idiopathic venous thromboembolism (VTE). Methods The study was based on information derived from Group Health Cooperative of Puget Sound for the period 1980 to 1994. Women aged 50–74 years admitted to hospital for idiopathic VTE were identified from hospital records. The diagnosis of idiopathic VTE was validated from the clinical record. Women who had medical conditions predisposing to VTE (a history of VTE or cancer, recent trauma, or surgery) were excluded as cases. Four control subjects matched to each case by age, duration of Cooperative membership, and calendar time were identified from the base population. Various potential risk factors were recorded based on record review. Findings An initial analysis of 42 cases and 168 matched controls yielded a matched relative risk estimate of 3·6 (95% CI 1·6–7·8) for current users of oestrogens compared with non-users. There was a substantial effect of daily oestrogen dose. The matched relative risk estimates for oestrogen users of 0·325 mg, 0·625 mg, and 1·25 mg or more daily were 2·1, 3·3, and 6·9, respectively. Body-mass index was independently associated with the risk of VTE but did not materially confound the relation of oestrogen and VTE. The absolute risk of idiopathic VTE is estimated to be low (0·9×10−4 woman-years) in non-users of oestrogen; the risk in current users is estimated at 3·2×10−4 woman-years. Interpretation The risk of idiopathic VTE is about three times higher among current users of replacement oestrogens than among non-users. However, the absolute risk is low for both groups and accounts for only a modest increase in morbidity.
Septic Shock and Bacteremia Associated with Laparoscopic Guided Liver Biopsy, Report on Two Cases
Authors: M. Domingo, J. Grau, A. Vázquez, A. Díez, J. Coll, J. Vivancos
Journal: Endoscopy (1989)

Two cases of infectious complications after liver biopsy are reported. Klebsiella pneumoniae and beta-hemolytic Streptococcus were cultured. In both cases the biopsy was obtained under laparoscopic control. A 28-year-old woman with liver cirrhosis died 24 hours after liver biopsy as a result of septic shock and disseminated intravascular coagulation. A 67-year-old man with hepatic fibrosis suffered from transient bacteremia and recovered uneventfully after antibiotic therapy. In these patients, there was evidence to implicate pre-existing cholangitis as factor predisposing to postbiopsy bacteremia.