tbuckley/cabot-search huggingface dataset:
Physical and Psychological Triggers for Attacks in Ménière’s Disease: The Patient Perspective
Authors: Sarah E. Kirby, Lucy Yardley
Journal: Psychotherapy and Psychosomatics (2012)

Meniere’s disease (MD) is a debilitating disease of the inner ear for which the main symptoms comprise vertigo, hearing loss, tinnitus and a sense of fullness or pressure in the ear. Residual and movement-provoked dizziness may also occur between major attacks. High levels of psychiatric comorbidity, disability and reduced quality of life are often reported among people who experience such symptoms [1, 2] . Attacks cannot be prevented, and a great deal of uncertainty and distress exists in relation to when symptoms might occur and what might trigger them. Understanding the patient perspective is particularly relevant to the diagnosis and management of vestibular disorders, as reported triggers of dizziness and vertigo inform the diagnosis of vestibular symptoms [3] , and the treatment of symptoms and related distress often involve lifestyle changes and self-management. It is therefore important for clinicians to be aware of the patient’s frame of reference (i.e. their subjective beliefs, perceptions and experiences) when eliciting information about symptoms and triggers. No previous research in this area has carried out an in-depth investigation specifically focusing on beliefs and views about triggers, or sought to identify whether different perceived triggers are associated with different symptoms. The aim of this study was to carry out an in-depth qualitative exploration of views and beliefs about triggers of symptoms of MD and to relate these to the different types of reported symptoms. Semistructured telephone interviews employing open-ended questions were carried out with 20 members of the Meniere’s Society (a UK-based self-help group for people with dizziness and balance disorders) who had completed screening questionnaires and fulfilled inclusion criteria. These comprised experiencing symptoms of vertigo during the past 12 months, current symptoms of tinnitus, aural fullness and hearing disability, and had received a diagnosis of MD from their doctor. Participants were encouraged to give as much detail as possible of their own experiences and views of the warnings and triggers for any symptoms they considered to be an ‘attack’ of MD. As we were interested in participants’ own perspective, interviews were participant led, and we did not offer participants a definition for the term ‘attack’ or request the discussion of particular symptoms. Data were analysed using inductive thematic analysis supplemented by ground
Effect of dexamethasone on in vivo prostanoid production in the rabbit.
Authors: A Náray-Fejes-Tóth, G Fejes-Tóth, C Fischer, J C Frölich
Journal: Journal of Clinical Investigation (1984)

To investigate the effects of antiinflammatory steroids on in vivo prostaglandin production, urinary excretion rates of six different cyclo-oxygenase products were determined before, during, and after the administration of dexamethasone (1 mg/kg per d). Urine was collected in metabolism cages and was analyzed for prostaglandins E2 and F2 alpha (PGE2 and PGF2 alpha) by radioimmunoassay after open-column chromatography; 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) and thromboxane B2 (TxB2) were determined by radioimmunoassay after organic solvent extraction and reversed-phase high performance liquid chromatography; 7 alpha-hydroxy-5,11-di-keto-tetranorprostane-1,16-dioic acid (PGE-M) and 5 alpha,7 alpha-dihydroxy-11-keto-tetranorprostane-1,16-dioic-acid (PGF-M), the major urinary metabolites of prostaglandins E and F, were determined by gas chromatography-mass spectrometry and by radioimmunoassay, respectively. Dexamethasone failed to cause a statistically significant change in the excretion rate of PGE2 (control, 250.4 +/- 40.8; dexamethasone, 297.6 +/- 78.7 ng/kg per d). In contrast, PGF2 alpha excretion decreased during administration of dexamethasone (from 1,036 +/- 228 to 449 +/- 158 ng/kg per d; P less than 0.05). The urinary excretion rates of 6-keto-PGF1 alpha, TxB2, PGE-M, and PGF-M were not significantly altered by dexamethasone. (Control and dexamethasone values were, respectively, 63.6 +/- 7.9 and 103.5 +/- 17.9 ng/kg per d for 6-keto-PGF1 alpha; 13.0 +/- 3.0 and 14.8 +/- 2.1 ng/kg per d for TxB2; 1,251 +/- 217 and 1,905 +/- 573 ng/kg per d for PGE-M; and 4,131 +/- 611 and 4,793 +/- 600 ng/kg per d for PGF-M). Urine flow was significantly higher during dexamethasone administration (control, 159 +/- 24; dexamethasone, 305 +/- 29 ml/24 h; P less than 0.01). However, no correlation could be detected between changes in urine flow and changes in the excretion rate of any of the prostanoids investigated. It is concluded that the administration of pharmacological doses of glucocorticoids does not affect the basal rate of total body prostanoid synthesis.
C5-03: Open-label study of pemetrexed alone or in combination with a platinum for previously treated patients (pts) with malignant pleural mesothelioma (MPM): Outcomes from the International Expanded Access Program (EAP)
Authors: Ulrich Gatzemeier, Paul Taylor, Joachim von Pawel, Bruno Castagneto, Graham Dark, Maurizio Marangolo, Rob J. Van Klaveren, Jan Van Meerbeeck, Susumu Adachi, Johannes Blatter
Journal: Journal of Thoracic Oncology (2007)
889 CHEMOEMBOLIZATION WITH DRUG-ELUTING BEADS: RESULTS OF A COMPARISON STUDY BETWEEN HEPASPHERES™ AND DC BEADS™ LOADED WITH EPIRUBICIN
Authors: G. Poggi, C. Sottani, E. Leoni, P. Quaretti, A. Amatu, B. Porro, B. Montagna, B. Tagliaferri, F. Sottotetti, F. Zappoli, G. Bernardo, C. Minoia
Journal: Journal of Hepatology (2010)
(14) Essential fatty acids and the skin
Authors: C.E.H. Grattan, J.L. Burton
Journal: British Journal of Dermatology (1987)

Journal Article (14) Essential fatty acids and the skin Get access C.E.H. Grattan, C.E.H. Grattan Department of Dermatology, General Hospital, Birmingham Search for other works by this author on: Oxford Academic Google Scholar J.L. Burton J.L. Burton Department of Dermatology, Bristol Royal Infirmary, Bristol Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue s32, 1 June 1987, Pages 38–39, https://doi.org/10.1111/j.1365-2133.1987.tb12032.x Published: 01 June 1987
Renal ischemia/reperfusion remotely improves myocardial energy metabolism during myocardial ischemia via adenosine receptors in rabbits: effects of “remote preconditioning”
Authors: Atsushi Takaoka, Ichiro Nakae, Kenichi Mitsunami, Takahiro Yabe, Shigehiro Morikawa, Toshiro Inubushi, Masahiko Kinoshita
Journal: Journal of the American College of Cardiology (1999)
"Nonsustained": A Semantic Snake
Authors: BRENDAN PHIBBS
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 September 1980"Nonsustained": A Semantic SnakeBRENDAN PHIBBS, M.D.BRENDAN PHIBBS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-3-513_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The excellent article by Follansbee and colleagues (1) in the June issue of theAnnalsis marred by a semantic reptile that should be scotched before it becomes a full-blown viper. I refer to the use of "nonsustained" to describe brief paroxysms of ventricular tachycardia. Other authors have used this same miserable negative definer in the same context, and, unless strenous measures are taken, it may become a permanent and depressing resident of medical terminology. The word for a brief episode is "transient." Please, fellow workers, come back to the English language and the glories of its...Reference1. FOLLANSBEEMICHELSONMORGANROTH WEJ. Nonsustained ventricular tachycardia in ambulatory patients: characteristics and association with sudden cardiac death. Ann Intern Med. 1980;92:741-7. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BRENDAN PHIBBS, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1980Volume 93, Issue 3Page: 513-513KeywordsVentricular tachycardia ePublished: 1 December 2008 Issue Published: 1 September 1980 PDF downloadLoading ...
Rearrangement of CRLF2 in B-progenitor– and Down syndrome–associated acute lymphoblastic leukemia
Authors: Charles G Mullighan, J Racquel Collins-Underwood, Letha A A Phillips, Michael G Loudin, Wei Liu, Jinghui Zhang, Jing Ma, Elaine Coustan-Smith, Richard C Harvey, Cheryl L Willman, Fady M Mikhail, Julia Meyer, Andrew J Carroll, Richard T Williams, Jinjun Cheng, Nyla A Heerema, Giuseppe Basso, Andrea Pession, Ching-Hon Pui, Susana C Raimondi, Stephen P Hunger, James R Downing, William L Carroll, Karen R Rabin
Journal: Nature Genetics (2009)
Drosophila as a model system for molecular analysis of tumorigenesis.
Authors: B M Mechler, D Strand, A Kalmes, R Merz, M Schmidt, I Török
Journal: Environmental Health Perspectives (1991)

In Drosophila, homozygous mutations in a series of genes can cause the appearance of tissue-specific tumors. These tumors occur either during embryonic or larval development. The majority of the identified genes give rise to larval tumors that affect either the presumptive adult optic centers of the brain, the imaginal discs, the hematopoietic organs, or the germ cells. These genes act as recessive determinants of neoplasia and have been designated as tumor-suppressor genes. They are normally required for the regulation of cell proliferation and cell differentiation during development. Among these genes, the lethal(2)giant larvae (l(2)gl) has been best studied. Homozygous mutations in l(2)gl produce malignant tumors in the brain hemispheres and the imaginal discs. The l(2)gl gene has been cloned, introduced back into the genome of l(2)gl-deficient animals, and shown to restore normal development. The nucleotide sequence of the l(2)gl gene has been determined, as well as the sequence of its transcripts. Anti-l(2)gl antibodies recognize a protein of about 130 kDa that corresponds to the major product of l(2)gl transcripts. Analysis of the spatial distribution of l(2)gl transcripts and proteins revealed a first phase of intensive expression during embryogenesis and a second weaker phase during the larval to pupal transition period. As revealed by mosaic experiments, the critical period of l(2)gl expression for preventing tumorigenesis takes place during early embryogenesis. During this period, the l(2)gl protein is ubiquitously expressed in all cells and tissues, while during late embryogenesis expression becomes gradually restricted to the midgut epithelium and the axon projections of the ventral nervous system that show no phenotypic alteration in the mutant animals.(ABSTRACT TRUNCATED AT 250 WORDS)
Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1
Authors: Christoph A Gebeshuber, Christoph Kornauth, Lihua Dong, Ralph Sierig, Jost Seibler, Martina Reiss, Stefanie Tauber, Martin Bilban, Shijun Wang, Renate Kain, Georg A Böhmig, Marcus J Moeller, Hermann-Josef Gröne, Christoph Englert, Javier Martinez, Dontscho Kerjaschki
Journal: Nature Medicine (2013)
Scintigraphic and electrophysiological evidence of canine myocardial sympathetic denervation and reinnervation produced by myocardial infarction or phenol application.
Authors: J D Minardo, M M Tuli, B H Mock, R E Weiner, H P Pride, H N Wellman, D P Zipes
Journal: Circulation (1988)

Epicardial phenol application or transmural myocardial infarction in dogs produces sympathetic denervation of myocardium apical to the site of the intervention. Because efferent denervation is probably postganglionic, reinnervation most likely occurs but has not been shown. We investigated whether 123I-labeled metaiodobenzylguanidine (MIBG), a norepinephrine analogue taken up by sympathetic nerve terminals, could provide a scintigraphic image that would detect apical sympathetic denervation and possible reinnervation. Dogs underwent MIBG scintigraphic imaging at various times after phenol application or transmural myocardial infarction. The results of MIBG scintigraphy were correlated with electrophysiological responses obtained during ansae subclaviae and norepinephrine stimulation to establish the presence of neural denervation and reinnervation. Apical defects in the MIBG scan, which were associated with either normal perfusion by thallium or a smaller-sized defect, were found consistently in dogs that had apical sympathetic innervation. MIBG scintigraphic images returned to normal after 14 weeks (mean) at a time when reinnervation was shown to have occurred. Thus, the results of MIBG scintigraphy correlated accurately with the presence of denervation and reinnervation established by neuroelectrophysiological testing. Supersensitive refractory period shortening in response to norepinephrine infusion was present after denervation and persisted for more than 3 weeks after scintigraphic and electrophysiological evidence of reinnervation. Conclusions are that 1) MIBG can be used noninvasively to determine the presence of regional myocardial efferent sympathetic denervation and subsequent reinnervation, 2) reinnervation occurs after phenol application or transmural myocardial infarction, and 3) denervation supersensitivity persists even after reinnervation occurs.
The child who is slow to talk.
Authors: R J Robinson
Journal: BMJ (1982)

of the skin is a mandatory part of any general medical checkup.Malignant melanoma is much more common in whites living in sunny climates such as Australia, South Africa, and parts of the United States.The hazards of ultraviolet light irradiation aud the occurrence of malignant disease of the skin have become common public knowledge in these areas.In Britain the popular misconception is that there is not enough irradiation to result in any important degree of skin damage.This is not so, and, furthermore, many people also take holidays abroad.Though ultraviolet light is not the sole cause of malig- nant melanoma, excessive exposure is an important factor in its pathogenesis, particularly in people whose skin has a ten- dency to go red whether or not it subsequently tans.The prophylactic use of sunscreening agents should be a routine for such people.
Treatment of ANCA-Associated Vasculitis
Authors: Carol A. Langford
Journal: New England Journal of Medicine (2003)

Vasculitis is defined by inflammation of the blood-vessel wall and forms the pathological foundation of a diverse group of individual disease entities. Among the primary systemic vasculitic diseases, Wegener's granulomatosis and microscopic polyangiitis share several common features, including pulmonary capillaritis, pauci-immune focal crescentic necrotizing glomerulonephritis, and circulating antineutrophil cytoplasmic antibodies (ANCA) that are specific for proteinase 3 or myeloperoxidase. Because both diseases are highly associated with ANCA, they are sometimes collectively referred to as ANCA-associated vasculitis. However, the presence of granulomatous inflammation in Wegener's granulomatosis represents a potentially important distinction between these two rare diseases, and it remains unclear whether . . .
STUDIES ON MOUSE LEUKEMIA
Authors: Joseph Victor, James S. Potter
Journal: The Journal of Experimental Medicine (1934)

1. Two highly inbred strains of mice of different genetic constitution (Storrs-Little and C58) were used in a study of the influence of hosts on metabolism of cells of transmissible lymphatic leukemia. The experiments were carried out with leukemic cells of transmission Line I as well as with Line M-liver. About 50 per cent of the Storrs-Little mice were killed by each line of cells at this time, while 100 per cent of the C58 mice were killed. 2. The normal lymphoid tissues of the two strains of mice were significantly the same in regard to rates of oxygen consumption and both aerobic and anaerobic glycolysis. 3. Leukemic cells of Line I, growing in hosts of Strain Storrs-Little, gave significantly lower rates of aerobic and anaerobic glycolysis than when growing in hosts of Strain C58. Oxygen consumption was significantly higher. Leukemic cells of Line M-liver, growing in hosts of Strain Storrs-Little, gave significantly lower rates of aerobic and anaerobic glycolysis than when growing in Strain C58. Oxygen consumption was not significantly different. 4. After one to three passages through hosts of Strain Storrs-Little, the cell lines were returned to hosts of Strain C58, with immediate return to significantly the same metabolic rates originally given by each line in hosts of Strain C58. 5. These results lead to the more general conclusions that: (a) The genetic constitution of the host modifies the metabolism of the cell line. (b) The same host constitution may modify the metabolism of different cell lines in different ways. (c) Host constitution does not appear to modify the inherent constitution of the leukemic cells, but acts as a determining environmental factor on their metabolism.
Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional FcεRI
Authors: Tanya M. Laidlaw, John W. Steinke, Adrienne M. Tiñana, Chunli Feng, Wei Xing, Bing K. Lam, Sailaja Paruchuri, Joshua A. Boyce, Larry Borish
Journal: Journal of Allergy and Clinical Immunology (2011)
Functional consequences and intracoronary localization of alpha-adrenergic stimulation of the canine coronary circulation
Authors: Mary F. Maturi, Rodney Greene, Bryan Donqhue, Lynne M.A. Dorsey, Michael V. Green, Stephen L. Bacharach, Dino Vitale, Randolph E. Patterson
Journal: Journal of the American College of Cardiology (1986)
Lung function, respiratory illness, and passive smoking in British primary school children.
Authors: R J Rona, S Chinn
Journal: Thorax (1993)

BACKGROUND: Many studies have reported a significant association between parents9 smoking and reduced lung function in their children, but often the association has been found to be significant only in relation to maternal smoking. There have been few epidemiological studies on this topic in Britain. METHODS: Spirometry, in 2756 children aged 6.50-11.99 years, was carried out in a representative sample of English children, an inner city and ethnic minority sample, and a Scottish sample. Forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and forced expiratory flow rates of 25-75% and 75-85% (FEF25-75 and FEF75-85) were measured and standardised scores obtained separately for the English representative sample, the Scottish sample and subgroups in the inner city sample, white and Afro-Caribbean children and those originating from the Indian subcontinent. Multiple regression analyses were used to assess associations of FVC, FEV1, FEF25-75 and FEF75-85 with the passive smoking and respiratory illness, with adjustment for a large number of potential confounders. Passive smoking was defined in terms of reported number of cigarettes smoked at home by each parent. The respiratory symptoms and illnesses assessed were wheeze, asthma and bronchitis attacks, cough in the morning, and cough at any other time as reported by parents. RESULTS: Maternal smoking, but not paternal smoking, was associated with reduced FEF25-75 and FEF75-85 in boys. No association was found between passive smoking and lung function in girls, but in an analysis including both sexes the interaction of sex and parental smoking on lung function was not significant. With few exceptions, FEV1, FEF25-75 and FEF75-85 were reduced in children with wheeze and asthma attacks. CONCLUSIONS: The effect of passive smoking may depend on the close contact of a parent with a susceptible child as only maternal smoking in boys was significantly associated with impaired lung function. However, this explanation remains unsubstantiated. A parent9s report of wheeze and asthma attacks in the child is reflected in reduced lung function.
The neuropathy of the critically ill.
Authors: A C Williams, S Sturman, S Kelsey, F T Curran, J A Finnegan
Journal: BMJ (1986)

Effect of rapid referral on thickness of melanomasThe prognosis of patients with malignant melanoma is made worse by delay in seeking help.'Therefore, in 1981 a pigmented lesion clinic was started in Southampton with the object of minimising the delay between patients presenting to their general practitioner with a malignant melanoma and the melanoma being excised in hospital.The patients' prognosis was determined by the accepted method of measuring tumour thickness.
Excess weight risk factor for alcoholic liver disease
Authors: S. Naveau, V. Giraud, E. Borotto, A. Aubert, F. Capron, J. Chaput
Journal: Hepatology (1997)

Though the hepatotoxicity of ethanol has been established, only 8% to 20% of chronic alcoholics develop cirrhosis. The aim of this study was to assess whether being overweight is a risk factor for alcoholic liver disease. One thousand six hundred four alcoholic patients were studied. According to the liver biopsies, 194 patients had a normal liver; 402 had steatosis without fibrosis; 281 presented with fibrosis, with or without steatosis; 119 presented with acute alcoholic hepatitis (AAH) without cirrhosis; 232 indicated cirrhosis without AAH; and 179 presented with cirrhosis with AAH. One hundred ninety-seven patients had clinically obvious cirrhosis. In the study, five variables were studied as risk factors: age, sex, daily consumption of alcohol during the previous 5 years, the total duration of alcohol abuse, and tendency to be overweight (body mass index [BMI] > or = 25 in women and > or = 27 in men). The BMI was calculated according to the minimum weight over the 10 previous years. In the first stepwise logistic regression analysis, age, being overweight for at least 10 years, being of the female sex, and the total duration of alcohol abuse were independently correlated with the presence of cirrhosis. In the second analysis, female sex being overweight were the two independent risk factors of AAH. In the third analysis, being overweight for at least 10 years was the only independent risk factor of steatosis. These results show that the presence of excess weight for at least 10 years is a risk factor for cirrhosis, AAH, and steatosis. Our results suggest that there is a possible potential for the metabolic effects of ethanol ingestion caused by excess weight in patients with alcoholic liver disease.