tbuckley/cabot-search huggingface dataset:
Direct Payments for Rents and Rates
Authors: A. Elliott
Journal: BMJ (1967)

MEDICALJOUNALIt is proposed to reduce the size of the the C.C. and S. Committee from 96 to 82, which reduction includes the abolition of the 11 special group seats which provide direct representation for 5,378 consultants in specialties other than general surgery, general medicine, obstetrics, and gynaecology.It is doubtful whether a committee of 82 is any more efficient or manageable than one of 96, but it is undoubted that the proposed partial disenfranchisement of 5,378 consultants will be resented by those concerned.-Iam, etc.,
Case 2-1969
Authors: W. Davies Sohier, Roger A. Williams
Journal: New England Journal of Medicine (1969)

Presentation of Case First admission. A sixty-three-year-old man was admitted to the hospital because of generalized weakness and dyspnea.Five years previously a total laryngectomy had been performed because of a squamous-cell carcinoma; no local or metastatic spread was evident. Eight months before entry a right inguinal hernia was repaired; the hematocrit was 31 per cent, and the white-cell count 5900. Postoperatively, fever developed and subsided in tour days with penicillin and streptomycin therapy. Thereafter he was weak and lethargic, and dyspnea developed.On admission 3 hard lymph nodes, 1 cm in diameter, were felt in the supraclavicular region, and . . .
LARGE ACCIDENTAL VULVAR HEMATOMA AT TERM
Authors: COLIN G. ROBERTSON
Journal: JAMA (1910)

<h3>Accident.—</h3> On July 4, Mrs. A. R., aged 39, quintipara, Pregnant at term, while milking, was knocked down by a cow, and struck the vulva on a corner of a box. Immediately a vulvar tumor appeared, with lancinating pain, faintness and shock; the swelling increased until she was carried to the house and placed prone. Patient was seen in half an hour; pulse was 110, respiration 30, temperature 98. <h3>Examination.—</h3> There was found a tense globular tumor at vulva, as large as the head of a 9-pound child, elastic in consistency, purple in color, painful to the touch, and located in the right labium major. The vulvar orifice was displaced to the left, barely admitting a finger, which outlined the tumor for 3½ inches, along the bulging right vaginal wall. No varices were apparent. <h3>Treatment.—</h3> Under chloroform anesthesia, administered by Dr. George S. Tweedie, and with aseptic precautions, the tumor
Effectiveness of treatments for infantile colic: systematic review
Authors: P L B J Lucassen, W J J Assendelft, J W Gubbels, J T M van Eijk, W J van Geldrop, A K. Neven
Journal: BMJ (1998)

To evaluate the effectiveness of diets, drug treatment, and behavioural interventions on infantile colic in trials with crying or the presence of colic as the primary outcome measure.
Down-Regulation of Intratumoral <b> <i>Aromatase</i> </b> Messenger RNA Levels by Docetaxel in Human Breast Cancers
Authors: Yasuo Miyoshi, Seung Jin Kim, Kenji Akazawa, Shunji Kamigaki, Satsuki Ueda, Tetsu Yanagisawa, Tomoo Inoue, Tetsuya Taguchi, Yasuhiro Tamaki, Shinzaburo Noguchi
Journal: Clinical Cancer Research (2004)

Abstract Purpose: The reason why chemotherapy induces resistance to subsequent hormonal therapy remains to be clarified in postmenopausal breast cancers. We hypothesized that chemotherapy might down-regulate the intratumoral biosynthesis of estrogens. Thus, we have studied the influence of chemotherapy (docetaxel) on intratumoral aromatase mRNA expression because aromatase is a key enzyme for intratumoral biosynthesis of estrogens. Experimental Design: The mRNA levels of aromatase and its inducers [tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), and cyclooxygenase 2 (COX-2)] were determined by a real-time polymerase chain reaction assay in breast cancer tissues obtained before and after neoadjuvant chemotherapy with docetaxel (four cycles of 60 mg/m2 every 3 weeks) in 16 postmenopausal patients with estrogen receptor (ER)- and/or progesterone receptor (PR)-positive breast cancers. ER and PR levels in tumor tissues were also determined by enzyme immunoassay before and after chemotherapy. Results: The intratumoral aromatase mRNA levels decreased significantly (P &amp;lt; 0.05) after chemotherapy from 0.84 ± 0.28 (mean ± SE) to 0.47 ± 0.28. The intratumoral TNF-α mRNA levels also decreased significantly (P &amp;lt; 0.05) after chemotherapy from 2.40 ± 0.52 to 0.95 ± 0.25. On the contrary, the intratumoral IL-6 and COX-2 mRNA levels showed a marginally significant increase (P = 0.07) and a significant increase (P &amp;lt; 0.05), respectively, after chemotherapy. PR levels showed a marginally significant decrease (P = 0.08) after chemotherapy, whereas ER levels were almost constant before and after chemotherapy. Conclusions: Antitumor activity of docetaxel is mediated, at least in part, through a down-regulation of aromatase expression in tumor tissues, resulting in the suppression of intratumoral estradiol synthesis. Aromatase expression seems to be regulated mostly by TNF-α, but not IL-6 and COX-2.
Prognostic implications of novel beta cardiac myosin heavy chain gene mutations that cause familial hypertrophic cardiomyopathy.
Authors: R Anan, G Greve, L Thierfelder, H Watkins, W J McKenna, S Solomon, C Vecchio, H Shono, S Nakao, H Tanaka
Journal: Journal of Clinical Investigation (1994)

Three novel 63 cardiac myosin heavy chain (MHC) gene mis- sense mutations, Phe513Cys, Gly716Arg, and Arg719Trp, which cause familial hypertrophic cardiomyopathy (FHC) are described.One mutation in exon 15 (Phe513Cys) does not alter the charge of the encoded amino acid, and affected family members have a near normal life expectancy.The Gly716Arg mutation (exon 19; charge change of +1) causes FHC in three family members, one of whom underwent transplantation for heart failure.The Arg719Trp mutation (exon 19; charge change of -1) was found in four unrelated FHC families with a high incidence of premature death and an average life expec- tancy in affected individuals of 38 yr.A comparable high fre- quency of disease-related deaths in four families with the Arg719Trp mutation suggests that this specific gene defect di- rectly accounts for the observed malignant phenotype.Further, the significantly different life expectancies associated with the Arg719Trp vs. Phe513Cys mutation (P < 0.001) support the hypothesis that mutations which alter the charge of the en- coded amino acid affect survival more significantly than those that produce a conservative amino acid change.(J.Clin.Invest.
Ensuring Safe and Effective Medications for Children
Authors: Peter P. Budetti
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physiotherapy trials for the 21st century – time to raise the bar?
Authors: Alison Rushton, Mel Calvert, Chris Wright, Nick Freemantle
Journal: Journal of the Royal Society of Medicine (2011)

Although physiotherapy possesses examples of researchers and trials that are rigorous, broadly as a profession physiotherapy needs to address urgently the methodological quality of trials. This in turn will enable greater trust in trial and systematic review findings. As a minimum, all physiotherapy trials should be based on a trial protocol that explicitly addresses components of possible systematic bias (a priori specification of a primary outcome, randomization and concealment of allocation, blinding, intention-to-treat analysis, and avoidance of loss to follow-up) and the appropriate selection of outcome measures. Established physiotherapy researchers can facilitate this by providing consensus for minimum core sets of outcome measures for specific populations. The issues identified in this article have a wider reach than physiotherapy researchers; informing all disciplines that are without external regulation; as well as funding bodies, policymakers and commissioners.
Immediate effects of McConnell taping versus diamond wrap taping in symptomatic osteoarthritis knee
Authors: None Himanshu, Hitanshu Agnihotri
Journal: British Journal of Sports Medicine (2010)

Osteoarthritis (OA) is a group of mechanical abnormalities involving degradation of joints, including articular cartilage and subchondral bone. Patellar taping is one method, which has been studied earlier by various authors. However, the comparative effectiveness of different taping techniques still needs to be investigated. Henceforth, the objective of the present study was to evaluate the immediate effect of McConnell taping and Diamond wrap taping on symptomatic generalised OA knee. Thirty patients were selected from outpatient department of MM Institute of Physiotherapy and Rehabilitation, MM University, Mullana. They satisfied the American College of Rheumatology criteria for OA knee and were examined for pain and disability under three groups, that is, McConnell taping, Diamond wrap taping and neutral tape. The immediate benefits in pain scales in activities (walking speed and timed up and go test) using a visual analogue scale and disability scales for three activities (walking speed in metres per second, timed up and go test in second) were assessed.
VULVAL ATROPHY AND LEUKOPLAKIA.
Authors: H. J. WALLACE, I. W. WHIMSTER
Journal: British Journal of Dermatology (2006)

Journal Article VULVAL ATROPHY AND LEUKOPLAKIA. Get access H. J. WALLACE, M.A., M.D., M.R.C.P., H. J. WALLACE, M.A., M.D., M.R.C.P. Physician, Skin Department, St. Thomas's Hospital, London; Physician, St. John's Hospital for Diseases of the Skin, London Search for other works by this author on: Oxford Academic Google Scholar I. W. WHIMSTER, M.B., B.Chir. I. W. WHIMSTER, M.B., B.Chir. Lecturer in Pathology, St. Thomas's Hospital Medical School Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 63, Issue 7, 1 July 1951, Pages 241–257, https://doi.org/10.1111/j.1365-2133.1951.tb13721.x Published: 01 July 1951
LACK OF ANTI-HBc IgM IN NEONATES WITH HBsAg CARRIER MOTHERS ARGUES AGAINST TRANSPLACENTAL TRANSMISSION OF HEPATITIS B VIRUS INFECTION
Authors: A. Goudeau, G. Lesage, F. Denis, J.P. Chiron, B. Yvonnet, F. Barin, P. Coursaget, I.Diop Mar
Journal: The Lancet (1983)
Abdominal Section for Lead Colic.
Authors: J. C. Reeve
Journal: JAMA (1896)

Dayton, Ohio, March 18, 1896. <h3>To the Editor:</h3> —In your January issues which I have just seen, Prof. John B. Murphy reports a case of abdominal section for dynamic intestinal obstruction from lead poisoning and considers it the only one published. I also consider it the only one and am prompted therefore to report the following case of my own: A painter 20 years of age, had had no passage from the bowels for five days, according to one report ten days. Abdomen retracted and soft, but tender on one spot near the umbilicus; considerable pain; vomiting several days, so-called stercoraceous at last. He had had very copious irrigations, oil enemata, moderate salines and six drops of croton oil which probably was vomited. His condition was excellent, pulse slow and regular, temperature 99.6 degrees. Behavior peevish, so that operation was deferred as long as practicable. In the interim a third
S1 A New, Efficient Web-based Tool To Collect And Code Lifetime Job Histories In Large Population-based Studies: The Copd Project In The Uk Biobank Cohort
Authors: S. De Matteis, D. Jarvis, M. Wheatley, H. Azhar, A. Young, H. Young, L. Rushton, P. Cullinan
Journal: Thorax (2014)

<h3>Introduction and objectives</h3> The manual collection and coding of job histories is the standard method for assessing occupational exposure, but may be infeasible for large population-based studies such as the UK Biobank cohort. Our aim was to develop a new web-based tool to automatically collect and code individual lifetime job histories in the UK Biobank cohort for investigating the causes and burden of work-related COPD in the UK. <h3>Methods</h3> UK Biobank is a population-based cohort of 502,682 subjects, aged 40–69 years, recruited in 2006–2010. Baseline spirometry data, current employment and smoking histories were collected. We developed a job questionnaire based on the hierarchical structure of the standard occupational classification (SOC) 2000 to allow participants to automatically self-collect and code their lifetime job histories. The web-based prototype (www.imperial.ac.uk/biobank/questionnaire) was pre-piloted in May–August 2013 among key job sectors using snowball sampling together with a feedback survey. <h3>Results</h3> 171 subjects participated in both the pre-piloting and feedback survey. 91% completed the questionnaire in &lt;20 min, 85% considered the instructions clear, and 80% found their job categories/titles easily. Overall, 96% judged the questionnaire to be clear and easy. A revised questionnaire has now been designed and will be accessible from different media including PCs/laptops, tablets and smart phones to encourage high response. A demonstration version will be made available to conference participants. <h3>Conclusions</h3> Our web-based job questionnaire is an efficient new standard tool for collecting and automatically coding lifetime job histories in large population-based studies and is adaptable for use in many occupational and environmental health research projects.
Simultaneously Significant Hepatic and Mild Splenic Uptake of Tc-99m MDP Resulting From Waldenstrom Macroglobulinemia
Authors: Ji-Gang Yang, Cheng-Hong Yin, Chun-Lin Li, Lan-Fang Zou
Journal: Clinical Nuclear Medicine (2009)

Simultaneous significant hepatic and mild splenic uptake of Tc-99m methylene diphosphonate is not commonly seen in clinical practice. A case is presented of significant hepatic and mild splenic increased methylene diphosphonate activity in a 62-year-old woman. Subsequent serum protein electrophoresis showed monoclonal paraprotein in the gamma region and the final diagnosis is Waldenstrom macroglobulinemia.
A low-fat diet decreases high density lipoprotein (HDL) cholesterol levels by decreasing HDL apolipoprotein transport rates.
Authors: E A Brinton, S Eisenberg, J L Breslow
Journal: Journal of Clinical Investigation (1990)

Diets that reduce atherosclerosis risk lower levels of HDL cholesterol (HDL-C), but the significance of this is unclear. To better understand the mechanism of this phenomenon we studied the turnover of HDL apolipoproteins A-I and A-II in 13 subjects on two contrasting metabolic diets. Upon changing from high to low intake of saturated fat and cholesterol the mean HDL-C decreased 29% from 56 +/- 13 (SD) to 40 +/- 10 mg/dl, while apo A-I levels fell 23% from 139 +/- 22 to 107 +/- 22 mg/dl (both P less than 0.001). Mean apo A-II levels did not change. The fractional catabolic rate (FCR) of apo A-I increased 11% from 0.228 +/- 0.048 to 0.254 +/- 0.063 pools/d, while its absolute transport rate (TR) decreased 14% from 12.0 +/- 2.7 to 10.3 +/- 3.4 mg/kg per d (both P = 0.005). The decrease in HDL-C and apo A-I levels correlated with the decrease in apo A-I TR (r = 0.79 and 0.83, respectively; P less than 0.001), but not with the increase in apo A-I FCR (r = -0.04 and -0.02, respectively). In contrast, within each diet the HDL-C and apo A-I levels were inversely correlated with apo A-I FCR both on the high-fat (r = -0.85 and -0.77, P less than 0.001 and = 0.002, respectively) and low-fat diets (r = -0.67 and -0.48, P = 0.012 and 0.098, respectively) but not with apo A-I TR. In summary, diet-induced changes in HDL-C levels correlate with and may result from changes in apo A-I TR. In contrast, differences in HDL-C levels between people on a given diet correlate with and may result from differences in apo A-I FCR. Therefore, the mechanism of dietary effects on HDL levels differs substantially from the mechanism explaining the differences in levels between individuals on a fixed diet. In assessing coronary heart disease risk, it may be inappropriate to conclude that diet-induced decreases in HDL are equivalent to low HDL within a given diet.
Value of digital image processing of two-dimensional echocardiograms in differentiating active from chronic vegetations of infective endocarditis.
Authors: T Tak, S H Rahimtoola, A Kumar, N Gamage, P A Chandraratna
Journal: Circulation (1988)

The ability of a computer-based image digitizing system to differentiate "active" from "chronic" valvular vegetations was evaluated. Twenty-two patients with newly diagnosed infective endocarditis were studied prospectively by serial two-dimensional echocardiograms. Two comparable images (active and chronic) from the same patient taken several weeks apart (range, 4-17 weeks) after initiation of therapy were obtained at end diastole with identical gain settings. The images were digitized, magnified, and displayed on a high-resolution color monitor. The mean pixel intensity of the valvular vegetation in the active stage was 20.6 +/- 3.6 (mean +/- SD), which increased to 34.4 +/- 4.3 in the chronic stage (p less than 0.01). Because there was some overlap of values, an additional standardization procedure was used in the last eight patients. In these eight patients, the mean pixel intensity of the vegetations in the active stage was 17.5 +/- 1.1, and it increased at 4 weeks to 25.0 +/- 1.2 (p less than 0.05) and further increased in the chronic stage to 33.6 +/- 3.1 (p less than 0.05). There was no overlap of values between the active and chronic stages. Three clinical states are of particular interest: 1) The mean pixel intensity of the vegetations remained unchanged (23 vs. 24) in one patient who did not respond to antibiotic therapy. 2) The mean pixel intensity of the vegetations fell from 35 to 24 when one patient developed reinfection of the same valve, and with treatment, mean pixel intensity once again increased to 34. 3) The mean pixel intensity of the vegetations in five patients with culture negative infective endocarditis was low (21.6 +/- 1.9) and increased (33.6 +/- 6.0, p less than 0.05) during the chronic stage. The mean vegetation size was 0.73 +/- 0.30 cm2 in the active stage and decreased to 0.56 +/- 0.24 cm2 (p less than 0.05) in the chronic stage; however, in six of 22 patients (27%), vegetation size did not decrease with clinical cure.(ABSTRACT TRUNCATED AT 250 WORDS)
A1.16 Aberrantly expressed BOB1 in RA synovitis might contribute to the breach of immune tolerance
Authors: MJ Levels, M van Tok, DL Baeten, N Yeremenko
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Despite growing insights in the breach of immune tolerance, it remains currently unknown which molecules drive or control pathogenic B cells in human rheumatoid arthritis (RA). <h3>Objectives</h3> To identify cellular and molecular pathways implicated in RA-specific humoral autoimmunity. <h3>Methods</h3> Synovial tissue samples were obtained by arthroscopy from untreated individuals with RA and inflammation matched SpA controls. Gene expression profiling was performed on tissue samples using 44K Whole Genome Human microarrays. Top differentially expressed genes were validated on three independent cohorts by RT-qPCR and immunohistochemistry. Collagen-induced arthritis (CIA) experiments were conducted using Bob1-knockout mice and their littermate controls. <h3>Results</h3> Microarray screening for genes differentially expressed in the inflamed synovium revealed a prominent and disease-specific B cell signature with the B cell-specific transcriptional co-activator Bob1 among the most upregulated genes. Immunohistochemistry and real-time qPCR analyses conformed microarray data and demonstrated elevated expression of Bob1 not only in established RA, but also at the early phase of the disease. Next we determined whether lack of functional Bob1 modifies disease onset/or severity in CIA. The results showed that Bob1<sup>−/−</sup> mice were fully resistant to CIA compared to their wild-type (WT) littermates and failed to produce pathogenic anti-collagen autoantibodies. To determine whether this remarkable resistance to CIA is related to failure of germinal centre (GC) formation or to intrinsic B cell defects in the absence of functional Bob1 we transferred WT B-cells to Bob1-deficient animals followed by CIA induction. After adoptive transfer Bob1-deficient mice were still resistant to CIA, suggesting that resistance to CIA is related to GC formation rather to intrinsic B cells defects in the absence of Bob1. In order to prove that functional Bob1 exclusively in B cells is required for susceptibility to CIA, we adoptively transferred various combinations of WT and Bob1-deficient B and T cells to RAG-1- <i>null</i> mice followed by CIA induction. The results showed that only animals that received WT B-cells displayed signs of arthritis and contained anti-collagen antibodies. <h3>Conclusions</h3> The specific increase in Bob1 expressing cells in RA synovitis and the resistance of Bob1-defecient mice to development of CIA indicate that Bob1 may contribute to humoral autoimmunity in RA. These data strongly suggest that expression of Bob1 in B cells is indispensable for GC formation and required for the development of CIA and the formation of anti-collagen antibodies. The mechanisms behind an aberrant Bob1 expression and the break of peripheral tolerance in RA is currently under investigation.
Government Policies in Violation of Human Rights as a Barrier to Professionalism
Authors: Farrah J. Mateen, Leonard S. Rubenstein
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal