Ranitidine and Acetaminophen Hepatotoxicity
Authors: Kermit V Speeg, D. C. Christian, M. C. Mitchell
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 February 1984Ranitidine and Acetaminophen HepatotoxicityK.V. SPEEG JR., M.D., PH.D., D.C. CHRISTIAN, M.D., M.C. MITCHELL, M.D.K.V. SPEEG JR., M.D., PH.D.Search for more papers by this author, D.C. CHRISTIAN, M.D.Search for more papers by this author, M.C. MITCHELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-2-315_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the recent editorial (1) comparing ranitidine and cimetidine. We agree that ranitidine will acquire its own profile of adverse effects but think the effect of ranitidine on cytochrome P-450 activity can be clarified.Ranitidine binds to cytochrome P-450 and if present in sufficient concentration would be expected to inhibit oxidation of other drugs by this microsomal enzyme system (2, 3). Ranitidine is much less potent as an inhibitor of cytochrome P-450 than cimetidine in all systems tested. The inhibition by ranitidine of acetaminophen metabolism cited in the editorial requires comment because this observation...References1. MCCARTHY D. Ranitidine or cimetidine [Editorial]. Ann Intern Med. 1983;99:551-3. LinkGoogle Scholar2. SPEEGPATWARDHANAVANTMITCHELLSCHENKER KRGMS. Inhibition of microsomal drug metabolism by histamine H2-receptor antagonists studied in vivo and in vitro in rodents. Gastroenterology. 1982;82:89-96. CrossrefMedlineGoogle Scholar3. RENDICALEBIC-KOLBAHKAJFEZRUF STFH. Interaction of ranitidine with liver microsomes. Xenobiotica. 1982;12:9-17. CrossrefMedlineGoogle Scholar4. BOYD M. Toxicity mediated by reactive metabolites of furans. Adv Exp Med Biol. 1980;136B:865-79. Google Scholar5. MITCHELLSCHENKERAVANTSPEEG MSGK. Cimetidine protects against acetaminophen hepatotoxicity in rats. Gastroenterology. 1981;81:1052-60. CrossrefMedlineGoogle Scholar6. MITCHELLSCHENKERSPEEG MSK. Selective inhibition of acetaminophen oxidation and toxicity by cimetidine and other H2-receptor antagonists in vivo and in vitro in the rat and in man. J Clin Invest. 1984. (In press). CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: K.V. SPEEGJR., M.D., PH.D.; D.C. CHRISTIAN, M.D.; M.C. MITCHELL, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUn anti-acide en prévention du syndrome de Mendelson : oui mais lequel ?Effect of ranitidine on acetaminophen-induced hepatotoxicity in dogsRanitidine drug interactions—a literature reviewRANITIDINE AND PARACETAMOL METABOLISMH2 Receptor Antagonists, Cytochrome P450, and Paracetamol-induced HepatotoxicityRanitidine and the LiverMARCOS A. SOUZA LIMA, M.D.Ranitidine, Acetaminophen, and HepatotoxicityJAMES E. BREDFELDT, M.D., CHRISTIAN VON HUENE, M.D. 1 February 1984Volume 100, Issue 2Page: 315-316KeywordsAttentionDrugsEnzymes ePublished: 1 December 2008 Issue Published: 1 February 1984 PDF downloadLoading ...