tbuckley/cabot-search huggingface dataset:
In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: age-related differences.
Authors: H.M. van Beuningen, P.M. van der Kraan, O.J. Arntz, W.B. van den Berg
Journal: Annals of the Rheumatic Diseases (1994)

OBJECTIVES--Transforming growth factor-beta (TGF-beta) has been shown to antagonise interleukin-1 (IL-1) effects in different systems. Investigations were carried out to study whether TGF-beta 1 modulates IL-1 induced inflammation and IL-1 effects on articular cartilage in the murine knee joint. METHODS--IL-1, TGF-beta 1 or both factors together were injected into the knee joint. Inflammation was studied in whole knee histological sections. Patellar cartilage proteoglycan synthesis was measured using 35S-sulphate incorporation while patellar cartilage glycosaminoglycan content was determined with automated image analysis on joint sections. RESULTS--Co-injection of TGF-beta 1 and IL-1 resulted in synergistic attraction of inflammatory cells. In contrast, TGF-beta 1 counteracted IL-1 induced suppression of articular cartilage proteoglycan synthesis. Proteoglycan depletion was similar shortly after the last injection of IL-1 or IL-1/TGF-beta 1, but accelerated recovery was found with the combination at later days. This protective effect of TGF-beta 1 could not be demonstrated in older mice. CONCLUSIONS--TGF-beta 1 aggravates IL-1 induced knee joint inflammation, but counteracts the deleterious effects of IL-1 on articular cartilage proteoglycan synthesis and content. The data indicate that TGF-beta 1 could play an important part in articular cartilage restoration after IL-1 induced proteoglycan depletion.
Human Rights and Child Health
Authors: Rosemary Chalk
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The skin barrier state of aged hairless mice in a dry environment
Authors: E.H. Choi, M.J. Kim, S.K. Ahn, W.S. Park, E.D. Son, G.W. Nam, I. Chang, S.H. Lee
Journal: British Journal of Dermatology (2002)

Journal Article The skin barrier state of aged hairless mice in a dry environment Get access E.H. Choi, E.H. Choi Department of Dermatology, Yonsei University, Wonju College of Medicine, Wonju, Korea Search for other works by this author on: Oxford Academic Google Scholar M.J. Kim, M.J. Kim Department of Dermatology, Yonsei University, Wonju College of Medicine, Wonju, Korea Search for other works by this author on: Oxford Academic Google Scholar S.K. Ahn, S.K. Ahn Department of Dermatology, Yonsei University, Wonju College of Medicine, Wonju, Korea Search for other works by this author on: Oxford Academic Google Scholar W.S. Park, W.S. Park Skin Research Institute, Pacific R & D Center, Yongin, Korea Search for other works by this author on: Oxford Academic Google Scholar E.D. Son, E.D. Son Skin Research Institute, Pacific R & D Center, Yongin, Korea Search for other works by this author on: Oxford Academic Google Scholar G.W. Nam, G.W. Nam Skin Research Institute, Pacific R & D Center, Yongin, Korea Search for other works by this author on: Oxford Academic Google Scholar I. Chang, I. Chang Skin Research Institute, Pacific R & D Center, Yongin, Korea Search for other works by this author on: Oxford Academic Google Scholar S.H. Lee S.H. Lee Department of Dermatology, Young Dong Severance Hospital, Yonsei University College of Medicine, 146‐92 Dogok‐Dong, Kangnam‐Ku, Seoul 135‐270, Korea Seung Hun Lee. E‐mail: ydshderm@yumc.yonsei.ac.kr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 147, Issue 2, 1 August 2002, Pages 244–249, https://doi.org/10.1046/j.1365-2133.2002.04918.x Published: 01 August 2002 Article history Accepted: 17 March 2002 Published: 01 August 2002
Loss of Vascular Endothelial Growth Factor A Activity in Murine Epidermal Keratinocytes Delays Wound Healing and Inhibits Tumor Formation
Authors: Heidemarie Rossiter, Caterina Barresi, Johannes Pammer, Michael Rendl, Jody Haigh, Erwin F. Wagner, Erwin Tschachler
Journal: Cancer Research (2004)

Abstract The angiogenic cytokine vascular endothelial growth factor (VEGF)-A plays a central role in both wound healing and tumor growth. In the skin, epidermal keratinocytes are a major source of this growth factor. To study the contribution of keratinocyte-derived VEGF-A to these angiogenesis-dependent processes, we generated mice in which this cytokine was inactivated specifically in keratin 5-expressing tissues. The mutant mice were macroscopically normal, and the skin capillary system was well established, demonstrating that keratinocyte-derived VEGF-A is not essential for angiogenesis in the skin during embryonic development. However, healing of full-thickness wounds in adult animals was appreciably delayed compared with controls, with retarded crust shedding and the appearance of a blood vessel-free zone underneath the newly formed epidermis. When 9,12-dimethyl 1,2-benzanthracene was applied as both tumor initiator and promoter, a total of 143 papillomas developed in 20 of 23 (87%) of control mice. In contrast, only three papillomas arose in 2 of 17 (12%) of the mutant mice, whereas the rest merely displayed epidermal thickening and parakeratosis. Mutant mice also developed only 2 squamous cell carcinomas, whereas 11 carcinomas were found in seven of the control animals. These data demonstrate that whereas keratinocyte-derived VEGF-A is dispensable for skin vascularization under physiological conditions, it plays an important albeit nonessential role during epidermal wound healing and is crucial for the development of 9,12-dimethyl 1,2-benzanthracene-induced epithelial skin tumors.
Cutaneous manifestations of zinc deficiency during treatment with anticonvulsants.
Authors: R I Simpson, D Bryce-Smith
Journal: BMJ (1985)

Osteomalacia presenting as pathological fractures during pregnancy in Asian women of high social class SrR,-We were interested to read the suggestion of Dr V Fonesca and others (16 February, p 555) that secondary hyperparathyroidism persists, despite treatment, in vegetarian Asians with nutritional osteomalacia.It
Relationship of Perfluorooctanoic Acid Exposure to Pregnancy Outcome Based on Birth Records in the Mid-Ohio Valley
Authors: David A. Savitz, Cheryl R. Stein, Beth Elston, Gregory A. Wellenius, Scott M. Bartell, Hyeong-Moo Shin, Veronica M. Vieira, Tony Fletcher
Journal: Environmental Health Perspectives (2012)

Perfluorooctanoic acid (PFOA) is a potential cause of adverse pregnancy outcomes, but previous studies have been limited by low exposures and small study size. Using birth certificate information, we examined the relation between estimated PFOA exposure and birth outcomes in an area of West Virginia and Ohio whose drinking water was contaminated by a chemical plant. Births in the study area from 1990 through 2004 were examined to generate case groups of stillbirth (n = 106), pregnancy-induced hypertension (n = 224), preterm birth (n = 3,613), term low birth weight (n = 918), term small-for-gestational-age (SGA) (n = 353), and a continuous measure of birth weight among a sample of term births (n = 4,534). A 10% sample of term births ≥ 2,500 g were selected as a source of controls (n = 3,616). Historical estimates of serum PFOA were derived from a previously developed fate and transport model. In a second study, we examined 4,547 area births linked to a survey with residential history data. In the analysis based only on birth records, we found no consistent evidence of an association between estimated PFOA exposure and stillbirth, pregnancy-induced hypertension, preterm birth, or indices of fetal growth. In the analysis of birth records linked to the survey, PFOA was unrelated to pregnancy-induced hypertension or preterm birth but showed some suggestion of an association with early preterm birth. Measures of growth restriction showed weak and inconsistent associations with PFOA. Based on the analysis using the health survey, these results provide little support for an effect of PFOA exposure on most pregnancy outcomes, except for early preterm birth and possibly fetal growth restriction.
A Midwife Through the Dying Process, by
Authors: B. Kelly
Journal: BMJ (1997)

Timothy E Quill / Johns Hopkins University Press, £20.50, pp 239 / ISBN 0 8018 5516 0

One of the recurring themes running through this series of case histories and discussions is the author's unshakable belief that the concept of “nonabandonment” should lie at the heart of good palliative care. Each case of …
The Asymptomatic Cardiac Ischemia Pilot (ACIP) study: Design of a randomized clinical trial, baseline data and implications for a long-term outcome trial
Authors: Carl J. Pepine, Nancy L. Geller, Genell L. Knatterud, Martial G. Bourassa, Bernard R. Chaitman, Richard F. Davies, Philip Day, John E. Deanfield, A.David Goldberg, Robert P. McMahon, Hiltrud Mueller, Pamela Ouyang, Craig Pratt, Michael Proschan, William J. Rogers, Andrew P. Selwyn, Barry Sharaf, George Sopko, Peter H. Stone, C.Richard Conti
Journal: Journal of the American College of Cardiology (1994)
Multicenter Phase II Study of Combination Therapy with Oral S-1 Plus Cisplatin in Elderly Patients with Advanced Gastric Cancer
Authors: Iwasa Satoru, Hamaguchi Tetsuya, Nagashima Kengo, Goto Masahiro, Okazaki Shunsuke, Sasaki Yusuke, Nagai Yushi, Asami Chika, Shimada Yasuhiro
Journal: Annals of Oncology (2014)
Abstract 5389: 3M-011, a toll-like-receptor-7/8 agonist, as immunological adjuvans in combined therapy of gastrointestinal tumors
Authors: Sebastian Schoelch, Conrad Rauber, Moritz Koch, Jürgen Weitz, Peter E. Huber
Journal: Cancer Research (2012)

Abstract Background: Although there are reports about spontaneous regressions in advanced cancer stages, in most cases the immune response to solid tumors is unable to stop the progression. This immune response is mediated mainly by effectors of the cellular immune system, specifically NK cells and monocytes/macrophages, which are activated by the binding of antigens to toll-like-receptors. 3M-011, an agonist to TLR-7/8 of this sub-family of pattern recognition receptors (PRRs) may be able to boost the antitumoral immune response, especially in combination with other immunostimulatory treatments such as monoclonal antibodies or ionizing radiation. Materials/Methods: In vivo experiments comprised hetero- and orthotopic mouse models of colorectal cancer evaluating 3M-011, m225 (mouse IgG to EGFR) and photon irradiation alone or in combination. End-points were tumor growth, metastasis and tumor cell dissemination. Mice with complete regressions were re-challenged with tumor cells to evaluate the immunization effect of the therapeutic combination. The cytotoxic activity of various immune cell populations (NK cells, CD-8+ T-cells, macrophages) against gastrointestinal cancer cell lines was quantified in 51Cr release assays. Interactions between these subpopulations were investigated by co-culture experiments. NfkB-Activation was quantified by luciferase-based NfkB reporter assays. Results: A distinct growth retardation for subcutaneous tumors and reduction in metastastic activity of orthotopic tumors was demonstrated in vivo. The combination of the TLR-7/8 agonist and m225 or photon irradiation was shown to be over-additive. Mice with complete regressions after radio-immuntherapy showed distinct anti-tumor immunity when re-challenged with tumor cells as compared to control animals. In vitro assays revealed NK cells in combination with monocytes/macrophages as main effectors of the TLR-mediated early immune response followed by T-cell mediated adaptive immune response. Both effects are controlled by plasmacytoid dentritic cells. On a cellular level, NfkB was shown to be the pivotal pathway of the TLR-mediated immunostimulatory effects as well as the combined therapy effects. Conclusion: The addition of a TLR-7/8 agonist to radiotherapy and antibody therapy can achieve supra-additive therapeutic effects by boosting the immune response to the tumor. Therefore, the addition of a TLR-7/8 agonist to the treatment of advanced gastrointestinal cancers is a promising approach and merits further evaluation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5389. doi:1538-7445.AM2012-5389
Oral Contraceptives and Thromboembolic Disease
Authors: Cecil Hougie
Journal: JAMA (1972)

<h3>To the Editor.—</h3> It is usually easy to find defects in any statistical study, either prospective or retrospective. A survey as large and inclusive as that of Drill and Calhoun (219:583,1972) on oral contraceptives and thromboembolic disease is particularly vulnerable since it includes a composite of data taken from various sources. Your various correspondents (220:416, 1972), who all appear to be proponents of the belief, based on retrospective studies, that the pill predisposes to thromboembolic disease, point out weaknesses in Drill's study, while some defend the validity of retrospective studies. In a previous letter to The Journal (208:865, 1969), I pointed out that thromboembolic disease is underdiagnosed to a remarkable degree. I also pointed out the probability that the publicity accorded the pill and its possible association with thrombophlebitis has resulted in the more careful examination of women who are taking the pill who have symptoms of leg or chest
Basal cell carcinoma arising in professional radiodermatitis of the nail
Authors: S. Serrano-Ortega, I. FernAndez-Angel, E. Dulanto-Campos, A. RodrIguez-Archilla, J. Linares-Solano
Journal: British Journal of Dermatology (2002)

Journal Article Basal cell carcinoma arising in professional radiodermatitis of the nail Get access S. Serrano‐Ortega, S. Serrano‐Ortega Departments of Dermatology and †Pathology, University Hospital San Cecilio, Granada, Spain*Department of Oral Medicine, School of Dentistry, University of Granada, Spain E‐mail: alberodr@ugr.es Search for other works by this author on: Oxford Academic Google Scholar I. FernÁndez‐Angel, I. FernÁndez‐Angel Departments of Dermatology and †Pathology, University Hospital San Cecilio, Granada, Spain*Department of Oral Medicine, School of Dentistry, University of Granada, Spain E‐mail: alberodr@ugr.es Correspondence: Isabel Fernández‐Angel, C/Torre del Capitan 12, ‘Edif. Gala’ Portal 1 2°A, E‐18008 Granada, Spain. Search for other works by this author on: Oxford Academic Google Scholar E. Dulanto‐Campos, E. Dulanto‐Campos Departments of Dermatology and †Pathology, University Hospital San Cecilio, Granada, Spain*Department of Oral Medicine, School of Dentistry, University of Granada, Spain E‐mail: alberodr@ugr.es Search for other works by this author on: Oxford Academic Google Scholar A. RodrÍguez‐Archilla, A. RodrÍguez‐Archilla Departments of Dermatology and †Pathology, University Hospital San Cecilio, Granada, Spain*Department of Oral Medicine, School of Dentistry, University of Granada, Spain E‐mail: alberodr@ugr.es Search for other works by this author on: Oxford Academic Google Scholar J. Linares‐Solano J. Linares‐Solano Departments of Dermatology and †Pathology, University Hospital San Cecilio, Granada, Spain*Department of Oral Medicine, School of Dentistry, University of Granada, Spain E‐mail: alberodr@ugr.es Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 147, Issue 3, 1 September 2002, Page 628, https://doi.org/10.1046/j.1365-2133.2002.500815.x Published: 01 September 2002
Atlas of Emergency Ultrasound
Authors: Christopher L. Moore
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Unusual Cause of Recurrent Chest Pain
Authors: David E. Fixler
Journal: JAMA (1975)

BY FAR the most common cause of pleural effusion in children is pulmonary infection. When infection is excluded as a cause of pleural effusion in a child, an uncommon or even rare cause must be sought. The case reported here was characterized by recurrent episodes of chest pain and pleural effusion. Bacterial infection was not present, and only after extensive studies did it become evident that the pleural effusion was caused by spontaneous drainage of pericardial effusion into the left pleural cavity through a congenital defect in the pericardium. <h3>Report of a Case</h3> A 12-year-old boy was transferred to Children's Medical Center with a four-day history of chest pain and orthopnea. He had not had any recent respiratory infection, fever, or chest trauma. Symptoms similar to current ones had occurred both 36 and 14 months earlier. During the latter illness, the boy had been hospitalized because of massive left pleural
Top adviser at the European Medicines Agency quits suddenly
Authors: P. Benkimoun
Journal: BMJ (2012)

The European Medicines Agency (EMA) announced on 4 April the immediate resignation of the chair of its Committee for Medicinal Products for Human Use (CHMP) in a short press release, which gave no reasons for his departure.

The document stated that the agency’s, director Guido Rasi, had accepted the resignation of Eric Abadie …
Abstract 4793: MUC1 immunogenicity in a triple transgenic mouse model for epithelial ovarian cancer
Authors: Raluca A. Budiu, Gina M. Mantia-Smaldone, Joan Brozick, Robert P. Edwards, Anda M. Vlad
Journal: Cancer Research (2010)

Abstract Background: Ovarian cancer continues to be associated with a very high mortality rate. Improvements on the development of new therapeutic approaches, including antigen-specific immune therapies, depend in part on the availability of adequate preclinical models for in vivo testing of treatment efficacy. MUC1 mucin is a tumor associated antigen and a potential target for cancer immunotherapy. Human and murine mucin 1 share little homology in the extracellular region and transgenic mouse models with de novo lesions expressing the human antigen are needed. Objective: To identify MUC1 antigen-specific immune regulation in mice with de novo malignant ovarian lesions. Methods: In order to generate a human MUC1 antigen expressing ovarian cancer mouse model, we crossed the MUC1 transgenic mice which express human MUC1 under the endogenous promoter with the previously described KrasG12D/+PtenloxP/loxP mice that develop orthotopic ovarian tumors. Results: The newly generated MUC1+/−KrasG12D/+ PtenloxP/loxP triple transgenic mice constitute a valuable Cre-loxP conditional in vivo model for MUC1 expressing ovarian tumors. Upon injection of Cre-encoding adenovirus under the ovarian bursa, the triple transgenic mice develop aggressive ovarian tumors with clear cell histology. The lesions express high levels of MUC1 and are estrogen receptor and cytokeratin 7-positive, markers classically used to diagnose malignant epithelial proliferation. The tumors are accompanied by ascites and numerous peritoneal implants, mimicking late stage disease clinically seen in women. We identified increased accumulation of Treg cells in the para-aortic (draining) lymph nodes and presence of Th17 cells in ascites, mimicking closely the immune phenotype of the human disease. In addition, using quantitative PCR T cell gene profiler arrays, we identified 5 significantly up- and 16 down-regulated genes in the spleen T cells of tumor-bearing mice. One of the upregulated genes was osteopontin (Spp1), recently validated as a marker in detecting human recurrent ovarian cancer. Among the down-regulated genes we identified, Cd4, Cd40ligand (Cd40lg), Interferon-g (Ifnγ), IL-23 receptor (IL-23ra) all suggestive of a shift in immune effectors, some of which may promote the chronic inflammatory background. Conclusions: Our results reveal important immune regulatory mechanisms in mice with de novo MUC1-expressing ovarian tumors and provide unique opportunities for future in vivo testing of MUC1 vaccines as ovarian cancer therapy and potentially immune prevention. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4793.