tbuckley/cabot-search huggingface dataset:
Molecular Basis of Cardiovascular Disease: A Companion to <i>Braunwald's Heart Disease</i>
Authors: Kenneth B. Desser
Journal: Annals of Internal Medicine (2000)

Medical Writings: Book Notes15 February 2000Molecular Basis of Cardiovascular Disease: A Companion to Braunwald's Heart DiseaseKenneth B. Desser, MDKenneth B. Desser, MDGood Samaritan Regional Medical Center, Phoenix, Arizona. (Desser)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-4-200002150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Chien KR, ed. 637 pages. Philadelphia: WB Saunders; 1999. $135.00. ISBN 0721664016. Order phone 800-654-2452.Field of medicine: Molecular cardiology and pharmacology.Format: Hardcover book.Audience: Students, internal medicine residents, cardiology fellows, research scientists, and clinical cardiologists.Purpose: To describe the potential impact of the new biology on cardiovascular disease, with emphasis on genetics and the molecular basis of cardiac disorders.Content: The textbook comprises seven sections plus a glossary. Initial chapters explain principles of molecular cardiology and morphogenesis. A mini-course in molecular biology, genetics, modified animal research models, and gene transfer approaches is included. Cloning, gene regulation, mitochondrial inheritance, ... Author, Article, and Disclosure InformationAffiliations: Good Samaritan Regional Medical Center, Phoenix, Arizona. (Desser) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 2000Volume 132, Issue 4Page: 332KeywordsAtherosclerosisCardiovascular diseasesCardiovascular therapyGenetic diseasesHeart diseasesMolecular biologyScientistsSoftware toolsStable coronary artery diseaseStroke ePublished: 15 August 2000 Issue Published: 15 February 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
So Much Insulin, So Much Hypoglycemia
Authors: Sei J. Lee
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Rapid expansion of TILs from patients with glioma and recognition of autologous tumor
Authors: Liu Zhenjiang, Qingda Meng, Oscar Persson, Bartek Jiri, Thomas Poiret, Lalit Rane, Elena B Rangelova, Ernest Dodoo, Markus Maeurer
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Tumor-infiltrating T cells (TIL) may represent a viable source of T cells for the biological treatment of patients with tumors of the central nervous system. We established a rapid TIL expansion protocol for patients with glioblastoma, and tested the recognition of short-term
Exogenous and Endogenous Determinants of Blood Trihalomethane Levels after Showering
Authors: Lorraine C. Backer, Qing Lan, Benjamin C. Blount, J.R. Nuckols, Robert Branch, Christopher W. Lyu, Stephanie M. Kieszak, Marielle C. Brinkman, Sydney M. Gordon, W. Dana Flanders, Marjorie Romkes, Kenneth P. Cantor
Journal: Environmental Health Perspectives (2007)

We previously conducted a study to assess whether household exposures to tap water increased an individual's internal dose of trihalomethanes (THMs). Increases in blood THM levels among subjects who showered or bathed were variable, with increased levels tending to cluster in two groups.Our goal was to assess the importance of personal characteristics, previous exposures, genetic polymorphisms, and environmental exposures in determining THM concentrations in blood after showering.One hundred study participants completed a health symptom questionnaire, a 48-hr food and water consumption diary, and took a 10-min shower in a controlled setting. We examined THM levels in blood samples collected at baseline and 10 and 30 min after the shower. We assessed the significance of personal characteristics, previous exposures to THMs, and specific gene polymorphisms in predicting postshower blood THM concentrations.We did not observe the clustering of blood THM concentrations observed in our earlier study. We found that environmental THM concentrations were important predictors of blood THM concentrations immediately after showering. For example, the chloroform concentration in the shower stall air was the most important predictor of blood chloroform levels 10 min after the shower (p < 0.001). Personal characteristics, previous exposures to THMs, and specific polymorphisms in CYP2D6 and GSTT1 genes were significant predictors of both baseline and postshowering blood THM concentrations as well as of changes in THM concentrations associated with showering.The inclusion of information about individual physiologic characteristics and environmental measurements would be valuable in future studies to assess human health effects from exposures to THMs in tap water.
LEPROSY IN BRITISH NATIONALS
Authors: STEPHEN GOLD
Journal: British Journal of Dermatology (1948)

Journal Article LEPROSY IN BRITISH NATIONALS Get access STEPHEN GOLD, M.B.Cantab., M.R.O.P.Lond. STEPHEN GOLD, M.B.Cantab., M.R.O.P.Lond. Late Major R.A.M.C Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 60, Issue 4, 1 April 1948, Pages 139–143, https://doi.org/10.1111/j.1365-2133.1948.tb11010.x Published: 01 April 1948
Langerhans cell histiocytosis reveals a new IL-17A–dependent pathway of dendritic cell fusion
Authors: Fabienne Coury, Nicola Annels, Aymeric Rivollier, Selma Olsson, Alessandra Santoro, Carole Speziani, Olga Azocar, Monique Flacher, Sophia Djebali, Jacques Tebib, Maria Brytting, R Maarten Egeler, Chantal Rabourdin-Combe, Jan-Inge Henter, Maurizio Arico, Christine Delprat
Journal: Nature Medicine (2007)
Fibrous histiocytoma of the lung.
Authors: J L Viguera, J L Pujol, S D Reboiras, J Larrauri, L S De Miguel
Journal: Thorax (1976)

A case of asymptomatic fibrous histiocytoma of the lung is described in a 14-year-old girl. A left thoracotomy was performed followed by partial resection of the lingula. Postoperative progress was uneventful.
Book: Sight Unseen
Authors: A. Fielder
Journal: BMJ (2000)

Georgina Kleege Yale University Press, £16.95, pp 233 ISBN 0 300 07680 0 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> Close to the top of every guru's list of exhortations is the advice that doctors should listen more to their patients. Here is your chance to do what you are told and enjoy the process. Sight Unseen offers a fascinating and scholarly glimpse into a specific impairment (blindness) and, more importantly, provides unique insight into the complex relation between normal function and impairment. This is not an autobiography but a book about blindness per se, by a writer who is … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Effect of Weight Loss and Lifestyle Changes on Vascular Inflammatory Markers in Obese Women
Authors: Katherine Esposito, Alessandro Pontillo, Carmen Di Palo, Giovanni Giugliano, Mariangela Masella, Raffaele Marfella, Dario Giugliano
Journal: JAMA (2003)

Context Obesity is an independent risk factor for cardiovascular disease, which may be mediated by increased secretion of proinflammatory cytokines by adipose tissue. Objective To determine the effect of a program of changes in lifestyle designed to obtain a sustained reduction of body weight on markers of systemic vascular inflammation and insulin resistance. Design and Setting Randomized single-blind trial conducted from February 1999 to February 2002 at a university hospital in Italy. Patients One hundred twenty premenopausal obese women (body mass index ≥30) aged 20 to 46 years without diabetes, hypertension, or hyperlipidemia. Interventions The 60 women randomly assigned to the intervention group received detailed advice about how to achieve a reduction of weight of 10% or more through a low-energy Mediterranean-style diet and increased physical activity. The control group (n = 60) was given general information about healthy food choices and exercise. Main Outcome Measures Lipid and glucose intake; blood pressure; homeostatic model assessment of insulin sensitivity; and circulating levels of interleukin 6 (IL-6), interleukin 18 (IL-18), C-reactive protein (CRP), and adiponectin. Results After 2 years, women in the intervention group consumed more foods rich in complex carbohydrates (9% corrected difference; P &amp;amp;lt;.001), monounsaturated fat (2%; P = .009), and fiber (7 g/d; P &amp;amp;lt;.001); had a lower ratio of omega-6 to omega-3 fatty acids (−5; P &amp;amp;lt;.001); and had lower energy (−310 kcal/d; P &amp;amp;lt;.001), saturated fat (−3.5%; P = .007), and cholesterol intake (−92 mg/d; P &amp;amp;lt;.001) than controls. Body mass index decreased more in the intervention group than in controls (−4.2; P &amp;amp;lt;.001), as did serum concentrations of IL-6 (−1.1 pg/mL; P = .009), IL-18 (−57 pg/mL; P = .02), and CRP (−1.6 mg/L; P = .008), while adiponectin levels increased significantly (2.2 µg/mL; P = .01). In multivariate analyses, changes in free fatty acids ( P = .008), IL-6 ( P = .02), and adiponectin ( P = .007) levels were independently associated with changes in insulin sensitivity. Conclusion In this study, a multidisciplinary program aimed to reduce body weight in obese women through lifestyle changes was associated with a reduction in markers of vascular inflammation and insulin resistance.
Intrarenal Distribution of Nutrient Blood Flow Determined with Krypton <sup>85</sup> in the Unanesthetized Dog
Authors: GEOFFREY D. THORBURN, HUGH H. KOPALD, J. ALAN HERD, MILTON HOLLENBERG, CHARLES C. C. O'Morchoe, A. CLIFFORD BARGER
Journal: Circulation Research (1963)

A method has been described for the measurement, by means of Kr 85 , of intrarenal nutrient blood flow distribution in the unanesthetized dog. Injection of the isotope into the renal artery is followed by a multi-exponential disappearance curve which can be obtained by external monitoring with a scintillation detector. In acute experiments autoradiographs have demonstrated that the first exponential component represents cortical blood flow; the second, outer medullary blood flow : the third, inner medullary blood flow; and the fourth, hilar and perirenal fat blood flow. The average cortical blood flow in 65 experiments in five kidneys of four nnanesthetized dogs was 472 ml/100 g/min, the outer medullary 132 ml/100 g/min, and the inner medullary 17 ml/100 g/min. Eighty per cent of the radioactivity was distributed initially to the cortex, 16% to the outer medulla, and 2% to the inner medulla. The hilar and perirenal fat, which receives approximately 2% of the initial radioactivity, was estimated to have a flow rate of 21 ml/100 g/min. In addition, a method for the rapid determination of serial cortical blood flow rates has been described. The importance of these findings has been discussed with reference to the anatomy of the kidney, and to the countercurrent concept as it applies to passive reabsorption of lipid soluble substances, and to the maintenance of an osmotic gradient.
U.S. Medical Practice before Medicare and Now — Differences and Consequences
Authors: Saul S. Radovsky
Journal: New England Journal of Medicine (1990)

The 1965 law establishing Medicare was a catalyst for change in the conditions of medical practice in the United States. This article reviews the law's effects, other changes occurring in the same period, and their consequences. It suggests why the morale of today's doctors is low, why they are more open to change than before, and why, more than ever, their interests need to be properly represented.The Way Things WereBefore the enactment of a program of limited national health insurance, the power of organized medicine was formidable. In 1962, when President Kennedy gave a speech favoring such an . . .
Immunosuppressive Serum Factors in Viral Hepatitis. II. Further Characterization of Serum Inhibition Factor as an Albumin-Associated Molecule
Authors: Norbert W. Brattig, Gabriele E. Schrempf-Decker, Christoph W. Brockl, Peter A. Berg
Journal: Hepatology (1983)

Immunosuppressive factor(s) in sera from patients with acute viral hepatitis B [serum inhibition factor(s) (SIF)] which functioned like an antiactivator of lymphocytes were further characterized and purified. The active moiety could be separated from immunoglobulins and other serum proteins by means of gel filtration, anion exchange, and affinity chromatography. The major SIF activity always copurified with albumin. Affinity chromatography with Cibacron blue agarose matrix followed by elution with 2 M NaCl proved an optimal procedure to obtain SIF-positive albumin fractions. The SIF moiety could be dissociated from albumin by use of 5 M NaCl or 6 M urea and was separated from protein by sequential molecular filtration and G-10 gel filtration indicating a low molecular weight substance. SIF activity of lower degree could also be detected in albumin-containing fractions derived from normal sera and exhibited similar biochemical properties as the factor which was isolated from patients' sera. The purified SIF fractions could not be stained with various protein dyes after sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The active moiety was partially extractable with chloroformrmethanol indicating a lipophilic nature. Common fatty acids or bile acids were excluded as causative factors by gas chromatographic-mass spectrometric and radioimmunologic analyses. These data suggest that the SIF effect is caused by an albumin-associated low molecular weight lipid or lipophilic peptide. SIF may be physiological immunoregulatory products of the immune system which are probably produced in response to a viral antigenic stimulus.
Expanded Repertoire of AAV Vector Serotypes Mediate Unique Patterns of Transduction in Mouse Brain
Authors: Cassia N Cearley, Luk H Vandenberghe, Michael K Parente, Erin R Carnish, James M Wilson, John H Wolfe
Journal: Molecular Therapy (2008)

A wide diversity of adeno-associated virus (AAV) structural proteins uncovered from latent genomes in primate tissue has expanded the number of AAV vector serotypes, which can potentially confer unique cell tropism to the vector. We evaluated 17 of these vectors in the mouse brain using green fluorescent protein (GFP) as a reporter gene. A rapid initial evaluation was performed by neonatal lateral ventricle injections. Vectors made with capsids hu.32, hu.37, pi.2, hu.11, rh.8, hu.48R3, and AAV9 for comparison were selected for further analysis based on their ability to transduce large numbers of cells and result in novel patterns of cell transduction. These vectors were injected into adult brains in four major structures (cortex, striatum, hippocampus, and thalamus), and all were found to transduce neurons. In addition, hu.32, hu.11, pi.2, hu.48R3, and rh.8 resulted in GFP expression in some astrocytes or oligodendrocytes. AAVs rh.8, pi.2, hu.32, and hu.11 also appeared to result in neuronal transport of the vector genome. Vector transport was studied by a single unilateral injection into the hippocampus and vector genome was found in projection sites of the hippocampus. These unique patterns of cell transduction expand the potential repertoire for targeting AAV vectors to selected subsets of brain cells. A wide diversity of adeno-associated virus (AAV) structural proteins uncovered from latent genomes in primate tissue has expanded the number of AAV vector serotypes, which can potentially confer unique cell tropism to the vector. We evaluated 17 of these vectors in the mouse brain using green fluorescent protein (GFP) as a reporter gene. A rapid initial evaluation was performed by neonatal lateral ventricle injections. Vectors made with capsids hu.32, hu.37, pi.2, hu.11, rh.8, hu.48R3, and AAV9 for comparison were selected for further analysis based on their ability to transduce large numbers of cells and result in novel patterns of cell transduction. These vectors were injected into adult brains in four major structures (cortex, striatum, hippocampus, and thalamus), and all were found to transduce neurons. In addition, hu.32, hu.11, pi.2, hu.48R3, and rh.8 resulted in GFP expression in some astrocytes or oligodendrocytes. AAVs rh.8, pi.2, hu.32, and hu.11 also appeared to result in neuronal transport of the vector genome. Vector transport was studied by a single unilateral injection into the hippocampus and vector genome was found in projection sites of the hippocampus. These unique patterns of cell transduction expand the potential repertoire for targeting AAV vectors to selected subsets of brain cells.
Diarrhoea due to Clostridium difficile associated with antibiotic treatment in patients receiving dialysis: the role of cross infection.
Authors: A D Cumming, B J Thomson, J Sharp, I R Poxton, A Fraser
Journal: BMJ (1986)

Retention of urine in occult anorectal herpesUrinary retention in patients with symptomatic anogenital herpes simplex infection is well documented.We report two cases ofmicturition difficulties in patients with occult anorectal infection.
Circulating Long-Chain ω-3 Fatty Acids and Incidence of Congestive Heart Failure in Older Adults: The Cardiovascular Health Study
Authors: Dariush Mozaffarian, Rozenn N. Lemaitre, Irena B. King, Xiaoling Song, Donna Spiegelman, Frank M. Sacks, Eric B. Rimm, David S. Siscovick
Journal: Annals of Internal Medicine (2011)

Few previous studies have evaluated associations between long-chain ω-3 fatty acids and incidence of congestive heart failure (CHF), and those that have are typically based on diet questionnaires and yield conflicting results. Circulating fatty acid concentrations provide objective biomarkers of exposure.To determine whether plasma phospholipid concentrations of long-chain ω-3 fatty acids, including eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA), were associated with incident CHF.Prospective cohort study.4 U.S. communities.2735 U.S. adults without prevalent heart disease who were enrolled in the Cardiovascular Health Study from 1992 to 2006.Plasma phospholipid fatty acid concentrations and other cardiovascular risk factors were measured in 1992 by using standardized methods. Relationships with incident CHF (555 cases during 26 490 person-years, adjudicated by using medical records) were assessed by using Cox proportional hazards models.After multivariate adjustment, plasma phospholipid EPA concentration was inversely associated with incident CHF; risk was approximately 50% lower in the highest versus the lowest quartile (hazard ratio [HR], 0.52 [95% CI, 0.38 to 0.72]; P for trend = 0.001). In similar analyses, trends toward lower risk were seen for DPA (HR, 0.76 [CI, 0.56 to 1.04]; P for trend = 0.057) and total long-chain ω-3 fatty acids (HR, 0.70 [CI, 0.49 to 0.99]; P for trend = 0.062) but not for DHA (HR, 0.84 [CI, 0.58 to 1.21]; P for trend = 0.38). In analyses censored to the middle of follow-up (7 years) to minimize exposure misclassification over time, multivariate-adjusted HRs were 0.48 for EPA (CI, 0.32 to 0.71; P for trend = 0.005), 0.61 for DPA (CI, 0.39 to 0.95; P for trend = 0.033), 0.64 for DHA (CI, 0.40 to 1.04; P for trend = 0.057), and 0.51 for total ω-3 fatty acids (CI, 0.32 to 0.80; P for trend = 0.003).Temporal changes in fatty acid concentrations over time may have caused underestimation of associations. Unmeasured or imperfectly measured covariates may have caused residual confounding.Circulating individual and total ω-3 fatty acid concentrations are associated with lower incidence of CHF in older adults.National Institutes of Health.
Convulsions in Children
Authors: Sidney Carter, Arnold Gold
Journal: New England Journal of Medicine (1968)

THE frequent occurence of convulsive seizures in the pediatric age group minimizes their true significance. Convulsions in infancy and childhood are not necessarily benign, and when prolonged may result in irreversible damage to the brain, with the production of additional epileptogenic foci and psychomotor retardation. In these patients worsening of the seizure state need not imply a progressive neurologic disease, but may be a reflection of the damage produced by the spells. Successful management of a convulsive disorder depends upon accurate identification of the seizure type, the delineation of etiologic factors and the proper use of anticonvulsants.EtiologyThe pathophysiology . . .
Adherence to Insulin and the Risk of Glucose Deterioration
Authors: Michael J. Blaha, Tom A. Elasy
Journal: Diabetes Care (2006)

Efforts to improve glucose control in patients with type 2 diabetes have been limited by the tendency for patients to experience glycemic deterioration during the maintenance phase of treatment. It has previously been reported that insulin use is a predictor of so-called “hyperglycemic relapse” (1). This previous retrospective study was limited by the inability to adjust for medication adherence, as this measure was not available in the database. Here, we reconsider the relationship between insulin use and hyperglycemic relapse in a prospective cohort study after consideration of medication adherence.

We studied 164 patients currently enrolled in a National Institute of Diabetes and Digestive and Kidney Diseases–funded Relapse Prevention Trial. Each patient in this study had documented previous …
REPORT OF TWO CASES OF HYDROPHOBIA, WITH POST-MORTEM EXAMINATION OF ONE CASE.Read before the Tri-State Medical Society at Angola, Indiana, July 14, 1891.
Authors: G. W. McCASKEY
Journal: JAMA (1892)

Cases of hydrophobia are fortunately so very rare, and the pathology of the disease so little understood, that I do not think any apology is necessary in offering the following contribution to the subject. The first case, alone, fell under my personal observation. A brief synopsis of the second is presented, which, while very imperfect, is yet believed to serve the purpose of giving a clinical picture in outline. <i>Case 1</i>.—On June 27, 1891, I was called in consultation with Dr. N. R. W., of Coesse, Ind., to visit Mr. R. D., æt, 76. The patient, a well-to-do farmer, had sent for Dr. Wenger on the evening of June 25, because of a feeling of oppression in the chest which had troubled him all day. From Dr. W. and the family I obtained the following history: About six weeks previously he had been bitten by a pet dog, which had been
Inflammatory Bowel Disease in African American Children Compared With Other Racial/Ethnic Groups in a Multicenter Registry
Authors: Jolanda M. White, Siobhán O'Connor, Harland S. Winter, Melvin B. Heyman, Barbara S. Kirschner, George D. Ferry, Stanley A. Cohen, Robert N. Baldassano, Terry Smith, Traci Clemons, Benjamin D. Gold
Journal: Clinical Gastroenterology and Hepatology (2008)