tbuckley/cabot-search huggingface dataset:
A 3-Year Follow-up of Sun Behavior in Patients With Cutaneous Malignant Melanoma
Authors: Luise Winkel Idorn, Pameli Datta, Jakob Heydenreich, Peter Alshede Philipsen, Hans Christian Wulf
Journal: JAMA Dermatology (2013)

IMPORTANCE UV radiation (UVR) exposure is the primary environmental risk factor for developing cutaneous malignant melanoma (CMM). OBJECTIVE To measure changes in sun behavior from the first until the third summer after the diagnosis of CMM using matched controls as a reference. DESIGN, SETTING, AND PARTICIPANTS Three-year follow-up, observational, case-control study performed from May 7 to September 22, 2009, April 17 to September 15, 2010, and May 6 to July 31, 2011, at a university hospital in Denmark of 21 patients with CMM and 21 controls matched to patients by sex, age, occupation, and constitutive skin type participated in the study. Exposure to UVR was assessed the first and second summers (n=20) and the first and third summers (n=22) after diagnosis. Data from 40 participants were analyzed. MAIN OUTCOMES AND MEASURES Exposure to UVR was assessed by personal electronic UVR dosimeters that measured time-related UVR in standard erythema dose (SED) and corresponding sun diaries (mean, 74 days per participant each participation year). RESULTS Patients' daily UVR dose and UVR dose in connection with various behaviors increased during follow-up (quantified as an increase in daily UVR dose each year; all days: mean, 0.3 SED; 95% CI, 0.05-0.5 SED; days with body exposure: mean, 0.6 SED; 95% CI, 0.07-1.2 SED; holidays: mean, 1.2 SED; 95% CI, 0.3-2.1 SED; days abroad: 1.9 SED; 95% CI, 0.4-3.4 SED; and holidays with body exposure: mean, 2.3 SED; 95% CI, 1.1-3.4 SED). After the second year of follow-up, patients' UVR dose was higher than that of controls, who maintained a stable UVR dose. No difference was found between groups in the number of days with body exposure or the number of days using sunscreen in the second and third years of follow-up. CONCLUSIONS AND RELEVANCE Our findings suggest that patients with CMM do not maintain a cautious sun behavior in connection with an increase in UVR exposure, especially on days with body exposure, when abroad, and on holidays.
Determinants and Prognostic Implications of Persistent ST-Segment Elevation After Primary Angioplasty for Acute Myocardial Infarction
Authors: Marc J. Claeys, Johan Bosmans, Leonard Veenstra, Philippe Jorens, None Herbert De Raedt, Chris J. Vrints
Journal: Circulation (1999)

Despite early recanalization of an occluded infarct artery, reperfusion at the level of the microcirculation may remain impaired owing to a process of microvascular reperfusion injury.Microvascular reperfusion injury was studied in 91 patients with acute myocardial infarction (AMI) by evaluation of the resolution of ST-segment elevation after successful PTCA. Impaired microvascular reperfusion, defined as the presence of persistent (>/=50% of initial value) ST-segment elevation (ST >/=50%) at the end of coronary intervention, was observed in 33 patients (36%) and was independently correlated with low systolic pressure on admission and high age. Patients >/=55 years of age with systolic pressures </=120 mm Hg were at high risk for development of impaired reperfusion compared with patients not meeting these criteria (72% versus 14%, P<0.001). Impaired microvascular reperfusion was associated with a more extensive infarction and worse clinical outcome at the 1-year follow-up: cardiac death rate, 15% versus 2% (ST >/=50% versus ST <50%, P=0.01); nonfatal MI rate, 9% versus 2% (P=0.1); and total major adverse cardiac event (MACE) rate, 45% versus 15% (P<0.005). ST >/=50% was the most important independent determinant of MACE with an adjusted risk ratio of 3.4.Impaired microvascular reperfusion, as evidenced by ST >/=50% after successful recanalization, occurs in more than one third of our AMI patients, especially in older patients with low systolic pressure. Its detrimental implications on clinical outcome reinforce the need to develop adjunctive agents that attenuate the process of reperfusion injury.
Family Characteristics of Diabetic Adolescents: Relationship to Metabolic Control
Authors: Barbara J Anderson, J Philip Miller, Wendy F Auslander, Julio V Santiago
Journal: Diabetes Care (1981)

This research compares the family environments of diabetic adolescents in good (HbA1c less than 10), fair (10 greater than or equal to HbA1c less than or equal to 14), and poor (HbA1c greater than 14) control. Fifty-eight adolescents diagnosed with type 1 diabetes and their parents (mothers) were independently assessed with structured interviews, the Moos Family Environment Scale, and adolescents also completed the Piers-Harris Children's Self-Concept Scale. As compared with adolescents in poor control, those in good control reported fewer diabetes-related symptoms and had less anxiety and a more positive self-concept. Well-controlled youths also reported more cohesion and less conflict among family members. More parents of well-controlled youths stated that family members were encouraged to behave independently. In addition, more parents of poorly controlled adolescents believed that diabetes had negatively affected the child's personality, physical well-being, schooling, and participation in activities away from home. These findings suggest a complex interplay between the diabetic adolescent's psychological and physical functioning, metabolic control, and the family environment.
Hereditary features, treatment, and prognosis of the lipoprotein glomerulopathy in patients with the APOE Kyoto mutation
Authors: Zhangxue Hu, Songmin Huang, Yu Wu, Yunqiang Liu, Xiaoxia Liu, Dan Su, Ye Tao, Ping Fu, Xiuhui Zhang, Ziying Peng, Sizhong Zhang, Yuan Yang
Journal: Kidney International (2013)
Surgical Quality Measurement
Authors: Mary T. Hawn
Journal: JAMA Surgery (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Intervention study for smoking cessation in diabetic patients: a randomized controlled trial in both clinical and primary care settings.
Authors: N Canga, J De Irala, E Vara, M J Duaso, A Ferrer, M A Martínez-González
Journal: Diabetes Care (2000)

To evaluate the effectiveness of a nurse-managed smoking cessation intervention in diabetic patients.This randomized controlled clinical trial involved 280 diabetic smokers (age range 17-84 years) who were randomized either into control (n = 133) or intervention (n = 147) groups at 12 primary care centers and 2 hospitals located in Navarre, Spain. The intervention consisted of a 40-min nurse visit that included counseling, education, and contracting information (a negotiated cessation date). The follow-up consisted of telephone calls, letters, and visits. The control group received the usual care for diabetic smokers. Baseline and 6-month follow-up measurements included smoking status (self-reported cessation was verified by urine cotinine concentrations), mean number of cigarettes smoked per day, and stage of change.At the 6-month follow-up, the smoking cessation incidence was 17.0% in the intervention group compared with 2.3% in the usual care group, which was a 14.7% difference (95% CI 8.2-21.3%). Among participants who continued smoking, a significant reduction was evident in the average cigarette consumption at the 6-month follow-up. The mean number of cigarettes per day decreased from 20.0 at baseline to 15.5 at 6 months for the experimental group versus from 19.7 to 18.1 for the control group (P < 0.01).A structured intervention managed by a single nurse was shown to be effective in changing the smoking behavior of diabetic patients.
Breast conservation in the treatment of T2 breast tumors – analysis of 1988-2003 SEER data.
Authors: R Rouzier, B Lesieur, J Gligorov, F Huguet, S Uzan
Journal: Cancer Research (2009)

Abstract Abstract #5151 Background: Breast-conserving therapy (BCT) has been shown to be as effective as mastectomy in the treatment of tumors 5 cm or smaller. However, few patients with tumors larger than 2 cm have been included in the randomized trials. We sought to investigate the prognosis of patients with tumors measuring 2.1 to 5 cm according to local treatment in the SEER database.&amp;#x2028; Methods: The SEER registry provided data from 17 registries. Survival was studied according to surgical treatment of tumor with stratifications on tumor size, nodal status, pathological characteristics and adjuvant radiation therapy. Cause specific survival was measured by SEER as the time from diagnosis to date of death and date of last follow-up, respectively. We used the Kaplan-Meier product limit method to describe cause specific survival and the log-rank test to assess differences between patient groups. All tests were two tailed, and p values &amp;lt; 0.05 were considered to denote significant differences. All analyses were performed using the R package with the Design, Hmisc, and Survival libraries.&amp;#x2028; Results: The study population comprised 128,454 patients. The median follow-up for patients alive at the last follow-up visit was 47 months. Survivals according to tumor size are reported in the table below. For patients with T2 tumors measuring 4.1-5cm, a better survival at 5 years (74%) was observed for patients treated by mastectomy compared to patients treated by BCT (67.5%) (P=1.22e-15) (Figure A). Subgroup analysis revealed that absence of radiation after BCT was the only reason for a higher survival in patients treated with mastectomy (Figure B). No clear deleterious effect of BCT was observed according to nodal status, grade or ER status.&amp;#x2028; Conclusion: Our study demonstrates that T2 tumor patients should not be treated with BCT if adjuvant radiation therapy cannot be administered.&amp;#x2028; &amp;#x2028; Survival according to local treatment in patients with 4.1-5 cm tumors.[figure1] Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 5151.
Diabetes and Renal Disease in Veterans
Authors: Bessie A. Young, Jacqueline A. Pugh, Charles Maynard, Gayle Reiber
Journal: Diabetes Care (2004)

OBJECTIVE—To describe the frequency and sequelae of diabetic renal disease in veterans who receive health care from the Veterans Administration (VA). RESEARCH DESIGN AND METHODS—Veterans with a diagnosis of diabetes, diabetic nephropathy, other kidney diseases, and end-stage renal disease (ESRD) were identified by diagnosis codes from national VA databases for FY1998. Data were obtained and analyzed for prevalence of renal disease, comorbid conditions, and 1-year mortality. RESULTS—A total of 44,671 (10.7%) of the 415,910 veterans with diabetes had a concomitant diagnosis of any renal disease. The average age was 67 years; 98% were male and 60% were white. The prevalence of diabetic nephropathy was 6.0% (n = 25,263). ESRD secondary to diabetes was present in 4.2% (17,636) of subjects. The age-standardized prevalence of diabetes and any renal disease was 72.6/1,000 persons and differed by race (white 76.1/1,000, black 103.4/1,000 persons). Diabetes-associated ESRD prevalence was higher among black versus white veterans and male versus female veterans. One-year age-standardized mortality was 10.7%. CONCLUSIONS—Nephropathy is prevalent in veterans with diabetes. Greater mortality is observed among those with renal disease compared with those without renal disease. Additional surveillance is needed to identify persons likely to progress to diabetic nephropathy and to plan for appropriate and timely health care for these individuals.
THE TREATMENT OF MALARIA
Authors: W. S. Dawson
Journal: BMJ (1920)

DCLJmgood judgement in picking up the required quantity with the knife-point.At the Belgrave Hospital printed directions for the use of the ointment are given to each parent by the surgeon in charge.They read as follows:BELGRAvE HOSPITAL FOB CHILDREN.Eve Department.Put a small piece of the ointmetnt (tbe size of a match head) inside the lower lid of EACH eye tlhree times every day, after breakfast, dinner, and tea, until you come next timie.Use a wax match with the bead cut off to put in the ointment.The eyes will open wide, and the -child will not be able to read, but may go to school.The ointlmient will be stopped when the doctor has ex'cmined the enes and ordered the glasses.Do not forget to use the ointment, or your visit will be wasted.Be careful with it, for it is very costly.Do not let any one else use it.From an experience of many years I find these directions are readily understood and cjrried out by tlhe parents.They have a further advantage, in tllat tlle simple explanation of the reasons for the use of tlle oint- ment, its effects, and their duration forestall objections from querulous parents.
ADDRESS OF WELCOME.
Authors: J. H. ELDRIDGE
Journal: JAMA (1889)

The Oldest Member of the Rhode Island Medical Society. Having reached that bad eminence—the oldest in fellowship of our State Society—an honor which I share with my friend Dr. Turner, who will address you this evening, the Chairman of our Committee of Arrangements has assigned to me the very pleasant duty of greeting you, gentlemen of the American Medical Association, and giving you a cordial welcome in behalf of the profession of Rhode Island on this, Fortieth Annual Meeting, which you have done us the honor to hold in this State. It goes without saying, that this is a very small State in point of territory. The most extravagant diminutive can hardly convey an idea of its proportions to those of you who come from without the limits of the New England States. We must also admit that the soil in many parts is barren, rough and unfit for cultivation,
Treatment of patients with hepatitis C and normal serum aminotransferase levels
Authors: Bruce R. Bacon
Journal: Hepatology (2002)

Approximately 30% of patients with chronic hepatitis C have normal serum alanine aminotransferase (ALT) levels and another 40% have ALT levels that are less than twice the upper limit of the normal range. Most patients with normal ALT levels have mild degrees of inflammation with mild or no fibrosis, and the rate of disease progression is reduced compared with that in patients with elevated ALT levels. Some patients with normal ALT levels have advanced fibrosis and cirrhosis on liver biopsy. Treatment of patients with normal ALT levels with either interferon monotherapy or interferon/ribavirin combination therapy has shown sustained virological response (SVR) rates that are equivalent to those achieved for patients with elevated ALT levels. Thus, patients with chronic hepatitis C should not be excluded from therapy based on ALT levels alone. The decision to initiate therapy with interferon and ribavirin should be based on a combination of factors independent of ALT levels including amount of fibrosis on liver biopsy, hepatitis C virus (HCV) genotype and viral level, patient age and motivation, and co-morbid illness, and the presence of other complicating conditions.
VOMITING OF PREGNANCY; ITS ETIOLOGY AND TREATMENT.Read before the Allegheny County Medical Society, June 16, 1891.
Authors: F. BLUME
Journal: JAMA (1891)

Pregnancy, as a rule, is complicated with a variety of disorders, which, though in many instances causing much discomfort, are termed physiological as long as they are not associated with serious disturbances of the organism. Derangements of the gastro-intestinal canal, nausea and vomiting, to the consideration of which I invite your attention to-night, are such a regular occurrence during the early period of pregnancy that experienced women consider them as positive signs of conception. The so-called morning sickness—nausea and vomiting early in the morning, or even after meals, during the first few months of gestation—have, in the large majority of cases, no effect either upon the course of pregnancy or upon the health of women. Although the ordinary morning sickness sometimes persists during the whole period of pregnancy, it remains endurable, causing the patient rather annoyance than injury. There are intermissions, either spontaneously or the consequence of some treatment; the
Exercise levels and resting pulse rate in the community.
Authors: G D Laird, M J Campbell
Journal: British Journal of Sports Medicine (1988)

A community survey examined attitudes to exercise in relation to health, measured levels of exercise participation, and related exercise participation to resting pulse rate. A questionnaire was sent to 400 Southampton residents selected by a systematic random sample from the electoral roll, and provided 259 useful responses, yielding an effective response rate of 68%, with an average age of 46 years. Attitudes to health benefits of exercise were generally very positive; 92% thought that exercise was important for staying in good health. Attitudes were less positive in subjects over 50 years old, and in social classes IV and V. Although 35% had done some vigorous exercise during the last four weeks only 7% of social classes IV and V had done so. A total of 22 (8.5%) had exercised for at least 20 minutes, 3 or more times per week, and 17 (77%) of these were males with an average age of 29 years. Ninety per cent of the sample were able to take their own resting heart rate. Resting heart rate was 7 beat.min-1 lower in subjects who exercised for at least 20 minutes 3 or more times per week than the average.
887 FIRST SERIES OF LIVER CELL TRANSPLANTATION FOR THE TREATMENT OF SEVERE NEONATAL UREA CYCLE DISORDERS
Authors: J. Meyburg, A. Das, F. Hoerster, M. Lindner, H. Kriegbaum, G. Engelmann, J. Schmidt, M. Ott, G.F. Hoffmann, A. Burlina
Journal: Journal of Hepatology (2008)
629 CEREBRAL OEDEMA IS RARE IN ACUTE-ON-CHRONIC LIVER FAILURE (AOCLF)
Authors: D. Joshi, A. Patel, J. O'Grady, E. Stern, D. Shawcross, S. Connor, C. Willars, W. Bernal, J. Wendon, G. Auzinger
Journal: Journal of Hepatology (2012)
Trends in Sudden Cardiovascular Death in Young Competitive Athletes After Implementation of a Preparticipation Screening Program
Authors: Domenico Corrado, Cristina Basso, Andrea Pavei, Pierantonio Michieli, Maurizio Schiavon, Gaetano Thiene
Journal: JAMA (2006)

A nationwide systematic preparticipation athletic screening was introduced in Italy in 1982. The impact of such a program on prevention of sudden cardiovascular death in the athlete remains to be determined.To analyze trends in incidence rates and cardiovascular causes of sudden death in young competitive athletes in relation to preparticipation screening.A population-based study of trends in sudden cardiovascular death in athletic and nonathletic populations aged 12 to 35 years in the Veneto region of Italy between 1979 and 2004. A parallel study examined trends in cardiovascular causes of disqualification from competitive sports in 42,386 athletes undergoing preparticipation screening at the Center for Sports Medicine in Padua (22,312 in the early screening period [1982-1992] and 20,074 in the late screening period [1993-2004]).Incidence trends of total cardiovascular and cause-specific sudden death in screened athletes and unscreened nonathletes of the same age range over a 26-year period.During the study period, 55 sudden cardiovascular deaths occurred in screened athletes (1.9 deaths/100,000 person-years) and 265 sudden deaths in unscreened nonathletes (0.79 deaths/100,000 person-years). The annual incidence of sudden cardiovascular death in athletes decreased by 89% (from 3.6/100,000 person-years in 1979-1980 to 0.4/100,000 person-years in 2003-2004; P for trend < .001), whereas the incidence of sudden death among the unscreened nonathletic population did not change significantly. The mortality decline started after mandatory screening was implemented and persisted to the late screening period. Compared with the prescreening period (1979-1981), the relative risk of sudden cardiovascular death in athletes was 0.56 in the early screening period (95% CI, 0.29-1.15; P = .04) and 0.21 in the late screening period (95% CI, 0.09-0.48; P = .001). Most of the reduced mortality was due to fewer cases of sudden death from cardiomyopathies (from 1.50/100,000 person-years in the prescreening period to 0.15/100,000 person-years in the late screening period; P for trend = .002). During the study period, 879 athletes (2.0%) were disqualified from competition due to cardiovascular causes at the Center for Sports Medicine: 455 (2.0%) in the early screening period and 424 (2.1%) in the late screening period. The proportion of athletes who were disqualified for cardiomyopathies increased from 20 (4.4%) of 455 in the early screening period to 40 (9.4%) of 424 in the late screening period (P = .005).The incidence of sudden cardiovascular death in young competitive athletes has substantially declined in the Veneto region of Italy since the introduction of a nationwide systematic screening. Mortality reduction was predominantly due to a lower incidence of sudden death from cardiomyopathies that paralleled the increasing identification of athletes with cardiomyopathies at preparticipation screening.
Atenolol, methyldopa, and chlorthalidone in moderate hypertension.
Authors: J Webster, T A Jeffers, D B Galloway, J C Petrie, N P Barker
Journal: BMJ (1977)

Combined treatment with low doses of different drugs is widely used for moderate hypertension. The effects of atenolol and methyldopa at two dose levels and in combination at the lower doses were studied in patients with moderate hypertension on continuous treatment with moderate hypertension on continuous treatment with chlorthalidone. The mean reduction in standing blood pressures obtained with atenolol 150 and 300 mg/day was about 27/17 mm Hg and with methyldopa 750 and 1500 mg/day about 28/14 mm Hg. Combined treatment with atenolol 150 mg/day and methyldopa 750 mg/day for four weeks resulted in a reduction of 38/25 mm Hg. No difference was observed between the two doses of methyldopa. The lower dose of atenolol was better than the lower dose of methyldopa in reducing lying and standing diastolic blood pressures. These findings show that in patients on continuous treatment with chlorthalidone the addition of atenolol alone or methyldopa alone or of atenolol and methyldopa in combination is effective in the treatment of moderate hypertension.