tbuckley/cabot-search huggingface dataset:
Perforation of a Dacron vascular endoprosthesis into the duodenum
Authors: H. Schwacha, W. Kern, D. Wagner
Journal: Endoscopy (2006)

A 65-year-old man with an aortobiiliacal vascular endoprosthesis developed an infection of his vascular graft with Staphylococcus aureus. He required emergency surgery because of rupture of the distal insertion, and during this procedure the duodenum was opened accidentally. The postoperative course was complicated by perigraft infection, including spondylodiscitis that required long-term antibiotic therapy.
INFECTED FOOD.Read before the Michigan State Medical Society, May 5.
Authors: VICTOR C. VAUGHAN
Journal: JAMA (1892)

<i>Mr. President and Gentlemen:</i>—Numerous examples of poisoning from cheese, canned salmon, sausage and other articles of food, have been reported within recent years. It has also been demonstrated that, in more than one instance, the milkman has distributed the germs of typhoid fever along with the lacteal fluid. There has been a great deal said about the spread of tuberculosis through infected meats. All of these are subjects of the greatest interest to the practicing physician. He does not know at what moment he may be called upon to treat a case of poisoning from canned meats. When he is confronted with an epidemie of typhoid fever, he must inquire into its origin, and at all times he needs to know, or wishes to know, all that can be known concerning the spread of tuberculosis. For these reasons, I have been led to collect the best information I can find
EFFECTS OF CALCIUM CHANNEL BLOCKER BENIDIPINE-BASED COMBINATION THERAPY ON CARDIAC EVENTS: SUB-ANALYSIS OF THE COPE TRIAL
Authors: Seiji Umemoto, Toshio Ogihara, Masunori Matsuzaki, Hiromi Rakugi, Kazuyuki Shimada, Junichi Yoshikawa, Masatoshi Kawana, Yasuo Ohashi, Takao Saruta
Journal: Journal of the American College of Cardiology (2014)
Concerns about cohorting of patients with suspected Ebola
Authors: M. Cormican
Journal: BMJ (2015)

Balancing the rights of the individual against the collective interest in preventing the spread of Ebola virus disease is challenging.1 2 One concern relates to the cohorting of patients with suspected Ebola.

Because the presentation of Ebola is relatively non-specific, any cohort will include people with and without the disease. Non-infected and infected people may share space for days. Some …
Genetic Proof-of-Concept for Cardiac Gene Expression in Human Circulating Blood-Derived Progenitor Cells
Authors: Stefan Rupp, Masamichi Koyanagi, Masayoshi Iwasaki, Florian Diehl, Philipp Bushoven, Dietmar Schranz, Andreas M. Zeiher, Stefanie Dimmeler
Journal: Journal of the American College of Cardiology (2008)
Use of the Spleen Scan in Evaluation of Pancreatic Pseudocyst
Authors: JANET A. PARKER, GEORGE L. POPKY, MOHAMMED T. YOUNIS
Journal: Clinical Nuclear Medicine (1976)

The case reported illustrates the value of the spleen scan, in conjunction with arteriography, in diagnosing splenic involvement by pancreatic pseudocyst. Of additional interest is the demonstration postoperatively of return of splenic activity.
Combining Free and Total Prostate Specific Antigen Assays from Different Manufacturers: The Pitfalls
Authors: Frank Oberpenning, Christoph Weining, Burkhard Brandt, Gabriela De Angelis, Achim Heinecke, Michael Hamm, Petra Stieber, Lothar Hertle, Hans-Peter Schmid, Axel Semjonow
Journal: European Urology (2002)
The Horizons of Health
Authors: Lester S. King
Journal: JAMA (1977)

With eminent contributors and well-planned contents, this book has a double purpose. It surveys recent research in various medical disciplines; it also pleads for a greater degree of public funding for basic medical research. The foreword, by Donald S. Fredrickson, director of the National Institutes of Health, sets the tone. Basic biomedical research, he points out, brings about "tangible improvements in health care." It has a substantial practical return with a high benefit-cost ratio. Investment in research is a good investment. The "potential benefits" of basic research are sufficiently great to warrant generous government funding. The book, both explicitly and implicitly, pleads for such public support. But this special pleading, however important it may have been in the planning of the book, is fortunately not really important in the finished product. In 27 well-written chapters, 32 authorities—all but one from Boston — describe progress in the past ten to 25
Progesterone cream for cyclic breast pain.
Authors: I. J. McFadyen, G. M. Raab, C. C. Macintyre, A. P. Forrest
Journal: BMJ (1989)

erythrocytes.It is partly explained by acute phase increases in plasma fibrinogen concentration and viscosity.In particular, however, we found that the filterability of both polymorphonuclear and mononuclear leucocytes is reduced in acute cerebral infarction.This may not only explain the reduced filterability of blood but also promote malperfusion of the microcirculation and infarction.Reduced filterability of leucocytes may be part of the acute phase response to injury, as suggested by the correlation with fibrinogen concentration in the patients with stroke and by similar findings in the
Asthma Control during the Year after Bronchial Thermoplasty
Authors: Gerard Cox, Neil C. Thomson, Adalberto S. Rubin, Robert M. Niven, Paul A. Corris, Hans Christian Siersted, Ronald Olivenstein, Ian D. Pavord, David McCormack, Rekha Chaudhuri, John D. Miller, Michel Laviolette
Journal: New England Journal of Medicine (2007)

Bronchial thermoplasty is a bronchoscopic procedure to reduce the mass of airway smooth muscle and attenuate bronchoconstriction. We examined the effect of bronchial thermoplasty on the control of moderate or severe persistent asthma.We randomly assigned 112 subjects who had been treated with inhaled corticosteroids and long-acting beta2-adrenergic agonists (LABA) and in whom asthma control was impaired when the LABA were withdrawn to either bronchial thermoplasty or a control group. The primary outcome was the frequency of mild exacerbations, calculated during three scheduled 2-week periods of abstinence from LABA at 3, 6, and 12 months. Airflow, airway responsiveness, asthma symptoms, the number of symptom-free days, use of rescue medication, and scores on the Asthma Quality of Life Questionnaire (AQLQ) and the Asthma Control Questionnaire (ACQ) were also assessed.The mean rate of mild exacerbations, as compared with baseline, was reduced in the bronchial-thermoplasty group but was unchanged in the control group (change in frequency per subject per week, -0.16+/-0.37 vs. 0.04+/-0.29; P=0.005). At 12 months, there were significantly greater improvements in the bronchial-thermoplasty group than in the control group in the morning peak expiratory flow (39.3+/-48.7 vs. 8.5+/-44.2 liters per minute), scores on the AQLQ (1.3+/-1.0 vs. 0.6+/-1.1) and ACQ (reduction, 1.2+/-1.0 vs. 0.5+/-1.0), the percentage of symptom-free days (40.6+/-39.7 vs. 17.0+/-37.9), and symptom scores (reduction, 1.9+/-2.1 vs. 0.7+/-2.5) while fewer puffs of rescue medication were required. Values for airway responsiveness and forced expiratory volume in 1 second did not differ significantly between the two groups. Adverse events immediately after treatment were more common in the bronchial-thermoplasty group than in the control group but were similar during the period from 6 weeks to 12 months after treatment.Bronchial thermoplasty in subjects with moderate or severe asthma results in an improvement in asthma control. (ClinicalTrials.gov number, NCT00214526 [ClinicalTrials.gov].).
Detection of Malignant Thymoma During Myocardial Perfusion Tomography With Tc-99m Sestamibi
Authors: ROBERTO SCIAGRÀ, ALESSANDRO PASSERI, LOREDANA POGGESI, MARIA MATTEINI, MARCO PELLEGRI, ITALIA PAGLIANITI
Journal: Clinical Nuclear Medicine (1998)

A 75-year-old patient had stress Tc-99m sestamibi SPECT to evaluate typical chest pain. A mediastinal mass in the thymic region was serendipitously detected. In high-quality SPECT images obtained using an iterative reconstruction algorithm, the mass dimensions were estimated and involvement of the heart wall was excluded. CT and surgical and histologic findings confirmed the diagnosis of a low-grade (stage II) malignant thymoma, the tumor size as assessed by SPECT, and the lack of pericardial involvement. This report suggests a possible role of Tc-99m sestamibi SPECT for diagnosing thymoma with foreseeable implications for tumor staging.
Analysis of the interactions between two molecules that are required for the expression of Ly-2 suppressor cell activity. Three different types of focusing events may be needed to deliver the suppressive signal.
Authors: P Flood, K Yamauchi, R K Gershon
Journal: The Journal of Experimental Medicine (1982)

We described a T suppressor factor made by an I-J- Ly-2 T cell (Ly-2 TsF) that expresses biological activity only when its acceptor cell shares H-2-linked polymorphic genes with the cells that made the Ly-2 TsF (or when the producer cell had differentiated in a thymic environment where the gene products of the acceptor cell were expressed). The Ly-2 TsF requires the presence of I-J+ Ly-1 cells in the assay culture to express its suppressive activity, although removal of the I-J+ Ly-1 cells in the assay cultures with an I-J+ soluble factor derived from them. This I-J+ molecule not only fails to bind antigen but is also antigen nonspecific in that it can come from Ly-1 cells making factors of irrelevant specificities. For the I-J+ molecule to replace the activity of the I-J+ Ly-1 cell in the assay population, in restoring suppressive function in cultures depleted of I-J+ Ly-1 cells, it must share genetic polymorphisms linked to the I-J subregion with the Ly-2 TsF and genetic polymorphisms linked to Igh-V with the target cell. These results indicate that an I-J+ antigen-nonspecific molecule combines with an antigen-specific Ly-2 TsF via an I-J- anti-I-J "type" of interaction. The resultant molecular complex is focused on a cell surface receptor of the acceptor cell. This focusing event is controlled by the antigen-nonspecific I-J+ molecule, and the precise interaction with the receptor on the acceptor cell is controlled by Igh-V-linked polymorphic gene products. The antigenic specificity of the interaction is controlled by a receptor for antigen on the I-J- component of the complex. Thus, three focusing events are required for Ly-2 TsF to express biologic activity: (a) the Ly-2 TsF must be focused on an acceptor cell that has the same antigenic specificity (most likely via an antigen bridge); (b) it must also be focused onto an I-J+ antigen-nonspecific molecule that we refer to as a "schlepper" molecule (most likely via an I-J anti-I-J bridge); and (c) the schlepper molecule must focus the molecular complex on an Igh-V-controlled receptor on the antigen-specific target cell.
Fear of hypercapnia is leading to inadequate oxygen treatment
Authors: G G Lavery
Journal: BMJ (1999)

EDITOR—Patients with proved hypoxaemia who are receiving a fractional inspired oxygen concentration of only 24-35% can be found in wards throughout the United Kingdom. Even this is overstating the case since masks often do not deliver the set oxygen concentration, 1 2 and an ill fitting facemask with a resultant increase in entrained room air will further reduce the inspired oxygen concentration.3 I was therefore delighted by Bateman and Leach's statement that “Inadequate oxygen accounts for more deaths …
AMA offers recommendations for vaccine injury compensation
Authors: M. F. Goldsmith
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Website of the week: Pet bereavement
Authors: N. Chohan
Journal: BMJ (2001)

In this week's Soundings (p 1195), Trisha Greenhalgh describes the emotional consequences of losing a pet. Doctors often have to help patients who have suffered a loss, but what can they offer beyond the normal constraints of bereavement support and counselling? Is there something specific for those who have lost pets and need help to manage their grieving?

In Memory of Pets (www.in-memory-of-pets.com) is a professional looking site, adorned with thumbnail pictures of angel cats and dogs, winging their way to heaven. As “one of only a few free and permanent pet loss and grief support sites on the internet,” it is making a concerted effort to help take the grieving process to its latter stages: daily and annual commemorative ceremonies. Now it is possible to join thousands of bereaved pet owners across the globe in a rosebud lined, candlelit vigil in honour of pets past and present.

The curiously named Lightning Strike (is it sudden death or a rapid support service?) “pet-loss support page” aims to provide everything a grieving pet person could want (www.lightning-strike.com). Post a message to tell the world how wonderful Fluffy was. Chat to other lost souls who have been through the same thing. The site is just a touch saccharine and, for those bursting to express their feelings through art, there is a section dedicated to poems commemorating those furry friends that have progressed to the afterlife.

Though it lacks the gloss and lustre of more professional sites, perhaps Lightning Strike offers the better “cybershoulder to cry on.” It lets you send a “Pet loss postcard” to offer your condolences to the recently bereaved. What better way to show that you care?

Of course, these sites aren't for everyone; some patients may feel that you aren't taking them seriously. The Association for Pet Loss and Bereavement (www.aplb.org) can help. It is a non profit organisation dedicated to supporting those who have lost a “beloved companion animal.” APLB was founded by professionals and provides publicity, literature, tapes, and counselling for those who are dramatically affected by the death of their pet.
Synthesis of histamine by Haemophilus influenzae.
Authors: B D Sheinman, J L Devalia, R J Davies, S J Crook, S Tabaqchali
Journal: BMJ (1986)

Recent findings suggest that bacteria might contribute to histamine concentrations in the sputum of patients with infective lung disease. Ten isolates of Haemophilus influenzae from patients with acute exacerbation of chronic bronchitis and emphysema, together with two reference strains, were incubated at 37 degrees C for 72 hours. Serial estimations of histamine concentrations by high pressure liquid chromatography showed significant increases at 24 and 48 hours; no increases were evident in the control samples. These findings suggest that H influenzae might contribute to inflammation and limited airflow in infective lung disease by producing histamine.
Circumstances of Accidental Poisoning in Childhood
Authors: R. H. Jackson, J. H. Walker, N. A. Wynne
Journal: BMJ (1968)

Of 377 children with accidental poisoning, the commonest ages were 1, 2, and 3. The most important contributory factor was that the poison was kept in an inappropriate place. Most containers were closed, but the children found them easy to open. In some cases the container itself was unsuitable for the contents.THE FREQUENCY OF POISONING IN CHILDHOOD MIGHT BE REDUCED IN SIX MAIN WAYS: (1) a reduction in the quantity of drugs kept in the home; (2) the provision of drug cupboards; (3) the provision of containers that are difficult for children to open, or individually foil-wrapping tablets; (4) making tablets less attractive to children; (5) clear identification of potential poisons; and (6) increasing parental awareness of the circumstances under which poisoning occurs.A plea is made for further sociomedical research into the prevention of poisoning.
Aortic Thrombosis in Antithrombin III Deficiency-Reply
Authors: Michael E. Shapiro
Journal: JAMA (1982)

<h3>In Reply.—</h3> We thank the authors for their comments and agree that depressed AT III levels may be the result of thrombosis rather than the cause. We do not think that this was the case in the patients we presented. The first patient was at least three weeks away from any short-term process when his AT III level was noted to be depressed. The second patient was noted to have low AT III levels four months after her vascular occlusion and well before gangrenous changes appeared. Although Marciniak et al reported increases in AT III levels by functional assay after warfarin administration, they did not report immunoassay data. More recently, there have been reports<sup>1,2</sup>of patients with well-documented familial AT III deficiency whose immunologically measured AT III levels increased to normal or near-normal levels after warfarin therapy. Other workers<sup>3</sup>have reported increased functional but not immunologic levels of
Hormonal and renal effects of atrial natriuretic peptide in patients with secondary hypertension.
Authors: Y Hirata, M Ishii, T Sugimoto, H Matsuoka, K Fukui, T Sugimoto, M Yamakado, H Tagawa, A Miyata, K Kangawa
Journal: Circulation (1988)

To investigate the involvement of atrial natriuretic peptide (ANP) in secondary hypertension, we examined hormonal and renal responses to ANP infusion (0.025 microgram/kg/min) in 27 patients with renal parenchymal hypertension, 10 with primary aldosteronism, 8 with renovascular hypertension, and 15 normotensive subjects. The preinfusion plasma concentration of ANP was significantly higher in patients with renal parenchymal hypertension (120 pg/ml, p less than 0.01) and in patients with primary aldosteronism (98 pg/ml, p less than 0.05) than in the normotensive subjects (40 pg/ml), but it was not greater than in the patients with renovascular hypertension (73 pg/ml, NS). In the patients with renal parenchymal hypertension, plasma ANP correlated negatively with creatinine clearance (r = -0.76, p less than 0.001). Mean blood pressure (-5%, p less than 0.01) and plasma aldosterone (-40%, p less than 0.001) decreased to a similar degree in the four groups during ANP infusion. However, an increase in urinary sodium excretion caused by ANP was higher in the hypertensive than in the normotensive patients (+250% vs. +70%, p less than 0.01) and correlated positively with mean blood pressure during ANP infusion (r = 0.47, p less than 0.001). The removal of adenomas in the patients with primary aldosteronism significantly lowered both plasma levels of ANP and cyclic guanosine 2',3'-monophosphate and reduced an increase in sodium excretion during ANP infusion, whereas the responses of blood pressure and plasma aldosterone to ANP infusion were not altered by the operation. Thus, these results suggest that elevated ANP secretion and increased natriuretic responses to ANP may modify the blood pressure and body fluid volume status in some types of secondary hypertension.
Warfarin or Not Warfarin?
Authors: Francisco J. Ruiz-Ruiz
Journal: Annals of Internal Medicine (2005)

Letters19 April 2005Warfarin or Not Warfarin?Francisco J. Ruiz-Ruiz, MDFrancisco J. Ruiz-Ruiz, MDFrom Hospital Clinico de Zaragoza, 50009 Zaragoza, Spain.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-8-200504190-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Warfarin or not warfarin? That is the question. Each day, physicians who treat elderly patients, especially octogenarians, consider this dilemma. Benefits of warfarin are well known in patients 75 years of age or older. However, compared with younger patients, this group is at higher risk for intracranial hemorrhage and other types of warfarin-associated bleeding. Fang and colleagues (1) examined the risk for intracranial hemorrhage according to age and international normalized ratio (INR). However, the patients they examined were not good candidates for warfarin therapy. For many reasons, it is more difficult to control INR in patients 85 ...Reference1. Fang MC, Chang Y, Hylek EM, Rosand J, Greenberg SM, Go AS, et al. Advanced age, anticoagulation intensity, and risk for intracranial hemorrhage among patients taking warfarin for atrial fibrillation. Ann Intern Med. 2004;141:745-52. [PMID: 15545674] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Hospital Clinico de Zaragoza, 50009 Zaragoza, Spain. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAdvanced Age, Anticoagulation Intensity, and Risk for Intracranial Hemorrhage among Patients Taking Warfarin for Atrial Fibrillation Margaret C. Fang , Yuchiao Chang , Elaine M. Hylek , Jonathan Rosand , Steven M. Greenberg , Alan S. Go , and Daniel E. Singer Warfarin or Not Warfarin? Margaret C. Fang and Daniel E. Singer Metrics 19 April 2005Volume 142, Issue 8Page: 676KeywordsChronic obstructive pulmonary diseaseDrugsElderlyHeart diseasesHeart failureHemorrhageNeurodegenerative diseasesStatins ePublished: 19 April 2005 Issue Published: 19 April 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Enterobius vermicularis infection.
Authors: G C Cook
Journal: Gut (1994)

We analyzed the association of HLA-DR and -DQ haplotypes and alleles with multiple sclerosis (MS) in 91 patients and 91 controls from Iceland using the relative predispositional effect method. The aim was to establish whether there is heterogeneity in HLA associations with MS, whether there are both predispositional and protective haplotypes, and whether sequence motifs also contribute to MS susceptibility. MS was positively associated with a DR2 haplotype (DRB5*0101-DQA1*0102-DQB1*0602), and empirical logistic analysis indicated that this haplotype is MS-associated because of a primary MS association with the DR2 allele. A DR13 haplotype (DRB1*1302-DQA1*0102-DQB1*0604) was negatively associated with MS, i.e., protective. Study of DR2-negative patients and controls confirmed this negative association and identified a second protective DR haplotype (DRB1*0701-DQA1*0201-DQB1*0201). Within these protective haplotypes in DR2-negative individuals, both DQA1 alleles and one DQB1 allele (*0604) were protective, but neither DR allele was protective, i.e., DQ loci may be more important than DR loci in encoding molecules protective against MS. Predispositional (Phe67) and protective (Ile67) DR beta sequence motifs were present in the total and DR2-negative patient and control groups. Since DQ but not DR alleles appear to be protective, DR beta Ile67 may confer additional protection against MS. Study of family-normal controls confirmed the MS association with the DR2 haplotype, and the transmission-disequilibrium test showed cosegregation and linkage of DR2 alleles and MS in families. <b>NEUROLOGY 1996;46: </b> 1107-1111
CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results
Authors: Brian G. Till, Michael C. Jensen, Jinjuan Wang, Xiaojun Qian, Ajay K. Gopal, David G. Maloney, Catherine G. Lindgren, Yukang Lin, John M. Pagel, Lihua E. Budde, Andrew Raubitschek, Stephen J. Forman, Philip D. Greenberg, Stanley R. Riddell, Oliver W. Press
Journal: Blood (2012)