Chemoprophylaxis of Malaria
Authors: ELIZABETH BARRETT-CONNOR
Journal: Annals of Internal Medicine (1978)

Editorial Notes1 September 1978Chemoprophylaxis of MalariaELIZABETH BARRETT-CONNOR, M.D.ELIZABETH BARRETT-CONNOR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-3-417 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn July 1977, three persons in a group of 20 American tourists to Africa developed malaria. The infection contributed to the death of one, nearly killed the second, and led to hospitalization in a foreign country for the third. All of the uninfected tourists and none of those infected were taking prophylaxis. Two of those who developed malaria had discussed chemoprophylaxis with their physicians and decided against chloroquine because of possible toxicity and eye damage. The third had discussed immunizations but not malaria prophylaxis with his physician.This true story (1) is not unique. Every year thousands of Americans travel...References1. : Malaria encounters of a deadly kind. Calif Morbid Weekly Rep Infect Dis Section No. 17, 5 May 1978 Google Scholar2. SCHULTZ M: Current concepts in parasitology. Parasitic diseases. N Engl J Med 297:1259-1261, 1977 CrossrefMedlineGoogle Scholar3. : Chemoprophylaxis of malaria. Morbid Mortal Weekly Rep 27 (10)(suppl):81-90, 10 March 1978 Google Scholar4. BARRETT-CONNOR E: Chemoprophylaxis of malaria for travelers. Ann Intern Med 81:219-224, 1974 LinkGoogle Scholar5. EBISAWA I, MUTO T, MITSUI G, and KAMEKO S: Malaria at Nam Ngum Dam construction site in Laos. I. Suppression with combinations of sulfonamides and pyrimethamine. Jpn J Exp Med 41:209-219, 1971 MedlineGoogle Scholar6. O'HOLOHAN D and HUGOE-MATTHEWS J: Malaria suppression and prophylaxis on a Malaysian rubber estate: sulformethoxine-pyrimethamine single monthly dose vs chloroquine single weekly dose. Southeast Asian J Trop Med Public Health 2:164-168, 1971 MedlineGoogle Scholar7. LEWIS A and PONNAMPALAM J: Suppression of malaria with monthly administration of combined sulphadoxine and pyrimethamine. Ann Trop Med Parasitol 69:1-12, March 1975 CrossrefMedlineGoogle Scholar8. PEARLMAN E, LAMPE R, THIEMANUN W, and KENNEDY R: Chemosuppressive field trials in Thailand. III. The suppression of Plasmodium falciparum and Plasmodium vivax parasitemias by a sulfadoxine-pyrimethamine combination. Am J Trop Med Hyg 26:1108-1115, 1977 CrossrefMedlineGoogle Scholar9. KEAN B and REILLY P: Malaria—the mime. Recent lessons from a group of civilian travellers. Am J Med 61:159-164, 1976 CrossrefMedlineGoogle Scholar10. NEVA F, SHEAGREN J, SHULMAN N, and CANFIELD C: Malaria: host-defense mechanisms and complications. Ann Intern Med 73:295-306, 1970 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ELIZABETH BARRETT-CONNOR, M.D.Affiliations: Department of Community Medicine University of California San Diego; La Jolla, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChloroquine as a hyperthermia potentiator4-AminoquinolinesMalaria in the emergency departmentIn vitro cultivation of malaria parasitesThe concentration of chloroquine in serum during short and long term malaria prophylaxis with standard and ‘double’ dosage in non-immunes: clinical implications 1 September 1978Volume 89, Issue 3Page: 417-418KeywordsChemopreventionChloroquineHospitalizationsMalariaProphylaxisToxicity ePublished: 1 December 2008 Issue Published: 1 September 1978 PDF downloadLoading ...