tbuckley/cabot-search huggingface dataset:
Metastatic Carcinoma at the Site of Injections of Iron-dextran Complex
Authors: J. D. Crowley, W. J. S. Still
Journal: BMJ (1960)

The virological investigations on 74 cases are briefly noted.The possible causes of death and their prevention are discussed.We are grateful to the nursing and resident medical staff of the paediatric department of Dudley Road Hospital, without whose help this investigation would not have been possible.We wish to acknowledge the technical assistance of Mr. A. J. Higgs, F.
Selective Involvement of the Amygdala in Systemic Lupus Erythematosus
Authors: Bart J Emmer, Jeroen van der Grond, Gerda M Steup-Beekman, Tom W. J Huizinga, Mark A van Buchem
Journal: PLoS Medicine (2006)

Antibodies specifically affect the amygdala in a mouse model of systemic lupus erythematosus (SLE). The aim of our study was to investigate whether there is also specific involvement of the amygdala in human SLE.We analyzed a group of 37 patients with neuropsychiatric SLE (NP-SLE), 21 patients with SLE, and a group of 12 healthy control participants with diffusion weighted imaging (DWI). In addition, in a subset of eight patients, plasma was available to determine their anti-NMDAR antibody status. From the structural magnetic resonance imaging data, the amygdala and the hippocampus were segmented, as well as the white and gray matter, and the apparent diffusion coefficient (ADC) was retrieved. ADC values between controls, patients with SLE, and patients with NP-SLE were tested using analysis of variance with post-hoc Bonferroni correction. No differences were found in the gray or white matter segments. The average ADC in the amygdala of patients with NP-SLE and SLE (940 x 10(-6) mm2/s; p = 0.006 and 949 x 10(-6) mm2/s; p = 0.019, respectively) was lower than in healthy control participants (1152 x 10(-6) mm2/s). Mann-Whitney analysis revealed that the average ADC in the amygdala of patients with anti-NMDAR antibodies (n = 4; 802 x 10(-6) mm2/s) was lower (p = 0.029) than the average ADC of patients without anti-NMDAR antibodies (n = 4; 979 x 10(-6) mm2/s) and also lower (p = 0.001) than in healthy control participants.This is the first study to our knowledge to observe damage in the amygdala in patients with SLE. Patients with SLE with anti-NMDAR antibodies had more severe damage in the amygdala compared to SLE patients without anti-NMDAR antibodies.
Importance of Estimated Functional Capacity as a Predictor of All-Cause Mortality Among Patients Referred for Exercise Thallium Single-Photon Emission Computed Tomography: Report of 3,400 Patients From a Single Center
Authors: Claire E Snader, Thomas H Marwick, Fredric J Pashkow, Sharon A Harvey, James D Thomas, Michael S Lauer
Journal: Journal of the American College of Cardiology (1997)
Veterinary center safeguards larger public
Authors: Terra Ziporyn
Journal: JAMA (1985)

"The M. he Center for Veterinary Medicine is really a microcosm of the Food and Drug Administration—for animals," says Gerald B. Guest, DVM, deputy director of the center. In other words, he explains, while there's a center each for human drugs, human devices, and human foods, this one center regulates all three for animals. Still, Guest says, "our first concern is public health, then animal welfare." Established in 1965, this center has five basic functions: To develop and recommend the veterinary medical policy of the FDA for the safety and efficacy of animal drugs, feed additives, and devices (including international activities and liaisons). To evaluate, for animal safety and efficacy, proposed and marketed animal drugs, feed additives, and devices. To coordinate the veterinary medical aspects of agency inspectional and investigational programs and to provide veterinary medical opinions in animal drug hearings and court cases. To plan,
Detecting Alcohol-Related Problems among General Hospital Patients with Heart Disease
Authors: Lefteris Lykouras, Ioannis Rontos, Kostas Rontos, Aris Katsaras, Theodore Markoulis, Evangelos Papasteriades, George N. Christodoulou
Journal: Psychotherapy and Psychosomatics (2001)

Certain epidemiologic studies suggest that moderate alcohol consumption decreases the risk of coronary heart disease. However, long-term excessive alcohol drinking is considered a major cause for a significant incidence of heart disease. Identifying alcohol-related problems among inpatients with cardiac disease is important.In this study, 209 male and 137 female inpatients with cardiac disease were screened for alcohol-related problems using the CAGE questionnaire. Associations of alcohol-related problems with sociodemographic and clinical variables were also investigated.Fifty-seven patients (16.5%) scoring positively on the CAGE questionnaire were considered as having alcohol-related problems. Logistic regression analysis revealed that alcohol-related problems were associated with sex (p = 0.00), age (p = 0.0497), and educational level (p = 0.0524). Men less than age 50, with cardiac disease and of lower education level should be considered at high risk for abnormal drinking. The probability increases from 5.2% for the whole sample to 41.9% for the group with these specific characteristics.The characteristics are useful for constructing a profile of the cardiology patient who is more likely to have alcohol-related problems. Early identification and vigorous and holistic treatment of these patients is important for secondary prevention of alcohol-related problems.
Points from Letters: Present State of Medicine
Authors: P. R. Buckton
Journal: BMJ (1964)

BRITSWhile Dr. Stephen does not quote the volume of water in his sink and bottle, it is obvious that the elusive 280 nm. of CO2 has been absorbed by the large quantity of liquid con- tained therein.In order to measure the actual C02 evolved from a beogex suppository it is necesary to collect the gas over a fluid in which it is insoluble, such as mercury or brine previously saturated with CO2.It is the latter fluid which we use for our assay purposes, and when calculating the total volume of gas evolved by this procedure one should also allow for the C02 which will dissolve in the small quantity of water used to promote the reaction.-Weare, etc.,
Effects of verapamil on left ventricular systolic function and diastolic filling in patients with hypertrophic cardiomyopathy.
Authors: R O Bonow, D R Rosing, S L Bacharach, M V Green, K M Kent, L C Lipson, B J Maron, M B Leon, S E Epstein
Journal: Circulation (1981)

Verapamil improves exercise capacity in patients with hypertrophic cardiomyopathy (HCM), but its mechanism of action are unknown. We examined the effects of oral verapamil (320-480 mg/day) on resting left ventricular (LV) systolic and diastolic function in patients with HCM. High-temporal-resolution time-activity curves from gated technetium-99m radionuclide angiograms were analyzed before and after verapamil therapy in 40 patients, of whom 16 were also studied during propranolol therapy (80-960 mg/day). All but one patient had normal or supranormal systolic function, but 70% had evidence of diastolic dysfunction, defined as peak LV filling rate (PFR) less than 2.5 end-diastolic volumes (EDV)/sec or time to PFR greater than 80 msec. Verapamil did not change LV ejection fraction, peak ejection rate or ejection time, but did increase PFR (control 3.3 +/- 1.0 EDV/sec, verapamil 4.1 +/- 1.1 EDV/sec; p less than 0.001) and reduce time to PFR (control 187 +/- 56 msec, verapamil, 159 +/- 34 msec; p less than 0.001). Only 30% of patients had evidence of diastolic dysfunction during verapamil. In contrast, propranolol did not change LV ejection fraction, PFR or time to PFR, but did prolong ejection time and reduce peak ejection rate. Thus, LV diastolic filling is abnormal in a high percentage of patients with HCM, and verapamil normalizes or improves these abnormalities without altering systolic function. This mechanism may contribute to the clinical improvement of many HCM patients during verapamil therapy.
Proctosigmoidoscopy from the Other End
Authors: JAMES H. THORPE
Journal: Annals of Internal Medicine (1976)

Comments and Corrections1 April 1976Proctosigmoidoscopy from the Other EndJAMES H. THORPE, M.D., F.A.C.P.JAMES H. THORPE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-4-497_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Doctor Magee's "Perspective" (Ann Intern Med 83:563-564, 1975) through the stirrups during pelvic examination stimulates another perspective that is shared by both sexes. It is that of a proctosigmoidoscopy, which can be as comfortable for a patient as it is informative for an examiner.Rather than urging every surgeon to undergo surgery, only to add to an already overpublicized market, it seems reasonable to recommend this procedure for every fledgling proctologist and gastroenterologist. Should it be a Board prerequisite?The experience would certainly deepen insight into the patient's plight, naked in a compromised position and attacked from... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Sutter Community Hospitals Sacramento, California 95816 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1976Volume 84, Issue 4Page: 497-497KeywordsGastroenterology and hepatologySurgeonsSurgery Issue Published: 1 April 1976 PDF DownloadLoading ...
1357 PENTOXIFYLLINE DOES NOT IMPROVE SHORT-TERM SURVIVAL IN SEVERE ALCOHOLIC HEPATITIS IN COMBINATION WITH CORTICOSTEROIDS: RESULTS OF A RANDOMIZED CONTROLLED TRIAL
Authors: A. Louvet, T.M. Dao, P. Nahon, E. Diaz, N. Carbonell, J. Boursier, R. Anty, D. Lebrec, R. Moirand, D. Thabut, C. Moreno, N. Talbodec, T. Paupard, S. Naveau, C. Silvain, G.-P. Pageaux, R. Sobesky, J. Salleron, A. Duhamel, P. Mathurin
Journal: Journal of Hepatology (2012)
Bone regeneration using hyaluronic acid-based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells
Authors: Jungju Kim, In Sook Kim, Tae Hyung Cho, Kyu Back Lee, Soon Jung Hwang, Giyoong Tae, Insup Noh, Sang Hoon Lee, Yongdoo Park, Kyung Sun
Journal: Biomaterials (2007)
Impaired Vasodilator Responses in Obstructive Sleep Apnea Are Improved with Continuous Positive Airway Pressure Therapy
Authors: VIRGINIA A. IMADOJEMU, KEVIN GLEESON, SADEQ A. QURAISHI, ALLEN R. KUNSELMAN, LAWRENCE I. SINOWAY, URS A. LEUENBERGER
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

Obstructive sleep apnea causes cardiovascular morbidity and premature death. Potential links between sleep apnea and cardiovascular complications are chronically elevated activity of the sympathetic nervous system and abnormal vascular function. To explore vascular function, we determined the reactive hyperemic blood flow (RHBF) responses to 10 minutes of forearm arterial occlusion (plethysmography), blood pressure, and muscle sympathetic nerve activity (MSNA, microneurography) in eight patients with sleep apnea and in nine nonapneic control subjects. Peak RHBF and vascular conductance were markedly attenuated in sleep apnea compared with control subjects (p < 0.05). Seven sleep apnea patients were retested after at least two weeks of continuous positive airway pressure (CPAP) therapy. MSNA decreased after CPAP therapy (p < 0.05, n = 6), whereas blood pressure did not change. After CPAP therapy, peak RHBF and vascular conductance were increased compared with before treatment (p < 0.05; n = 7). Thus, vascular function is abnormal in sleep apnea and is improved by CPAP therapy. Furthermore, effective CPAP therapy decreases sympathetic activity in sleep apnea. Thus, sympathoexcitation and abnormal vascular function in patients with sleep apnea appear to be linked to the repetitive nocturnal apneic events.
Schistosomiasis in the West Indies
Authors: S. G. Cowper
Journal: BMJ (1964)

in England that provide the same opportunity, and there should be little difficulty to train for final F.R.C.S. in these posts.I am rather sorry to see, yet again, the condemnation of the provincial hospitals by those in teaching centres.These hospitals do the bulk of the work and postgraduate training, and do both these tasks well, with only a few exceptions.It would, however, he helpful if, as in many other specialties, " exchange posts " for.regis- trars could be established between teaching and provincial hospitals.The minimum training requirement in E.N.T. (until recently at any rate) to enable a candidate to sit the final Fellowship in England was six months, and I believe nil in other centres.The general surgical training minimum for E.N.T. candidates of
Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs
Authors: B. Wu, T. Sato, T. Kiyosue, M. Arita
Journal: Cardiovascular Research (1992)

Journal Article Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs Get access Bowei Wu, Bowei Wu Department of Physiology, Oita Medical University, 1-1 Idaigaoka, Hasama-machi, Oita 879-55, Japan : B Wu, T Sato, T Kiyosue, M Arita. Correspondence to Dr Sato. Search for other works by this author on: Oxford Academic PubMed Google Scholar Toshiaki Sato, Toshiaki Sato Department of Physiology, Oita Medical University, 1-1 Idaigaoka, Hasama-machi, Oita 879-55, Japan : B Wu, T Sato, T Kiyosue, M Arita. Search for other works by this author on: Oxford Academic PubMed Google Scholar Tatsuto Kiyosue, Tatsuto Kiyosue Department of Physiology, Oita Medical University, 1-1 Idaigaoka, Hasama-machi, Oita 879-55, Japan : B Wu, T Sato, T Kiyosue, M Arita. Search for other works by this author on: Oxford Academic PubMed Google Scholar Makato Arita Makato Arita Department of Physiology, Oita Medical University, 1-1 Idaigaoka, Hasama-machi, Oita 879-55, Japan : B Wu, T Sato, T Kiyosue, M Arita. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 11, November 1992, Pages 1095–1101, https://doi.org/10.1093/cvr/26.11.1095 Published: 01 November 1992 Article history Received: 17 June 1992 Accepted: 10 August 1992 Published: 01 November 1992
Differential effect of IL‐15 and IL‐2 on survival of phytohemagglutinin‐activated umbilical cord blood T cells
Authors: Syh‐Jae Lin, Po‐Jen Cheng, Shiu‐Shan Hsiao, Hui‐Hao Lin, Pei‐Fen Hung, Ming‐Ling Kuo
Journal: American Journal of Hematology (2005)

Cytokine immunotherapy using interleukin (IL)-2 and IL-15 may be beneficial for patients receiving umbilical cord blood (CB) transplantation by ameliorating post-transplant T-cell apoptosis. The present study compares the differential effect of IL-15 and IL-2 on survival of phytohemagglutinin (PHA)-activated CB and adult peripheral blood (APB) T lymphocytes. In comparison with IL-2, IL-15 preferentially enhanced the survival of CB PHA-activated T cells by decreasing the caspase-3+ population and by increasing the Bcl-2+ population. Activated CB T cells were more susceptible to TNF-alpha-induced apoptosis compared to their adult counterparts. However, the susceptibility could be abrogated by IL-15 but not by IL-2. IL-15 but not IL-2 down-regulated CD28 expression on both activated CB and APB CD8+ T cells, with a much greater effect seen with CB. Western-blot analysis shows that IL-15 Ralpha is deficient in CB compared to APB immediately after PHA stimulation, while culturing with IL-15 significantly enhanced CB IL-15 Ralpha expression to levels comparable to that of adults. Thus, IL-15 may provide a better therapeutic choice for immune reconstitution than IL-2 post-CB transplantation due to its preferential survival enhancing effect on CB T cells.
Neuronal Proteins and Paraneoplastic Syndromes
Authors: Steven E. Kornguth
Journal: New England Journal of Medicine (1989)

AN early manifestation of small-cell carcinoma of the lung and ovarian carcinoma is peripheral or central nervous system dysfunction — the so-called paraneoplastic syndromes — which is frequently encountered before the tumor is detected. Paraneoplastic syndromes affecting the central nervous system include the loss of visual acuity1 , 2 and cerebellar dysfunction3; in the peripheral nervous system, they include sensory neuronopathy4 and Lambert–Eaton myasthenic syndrome. This issue of the Journal contains two articles related to paraneoplastic syndromes associated with small-cell carcinoma of the lung: McEvoy and colleagues describe the efficacy of 3,4-diaminopyridine in the treatment of the Lambert–Eaton syndrome,5 and Thirkill . . .
Increased risk of recurrence of pregnancies complicated by fetal neural tube defects in mothers receiving poor diets, and possible benefit of dietary counselling.
Authors: K M Laurence, N James, M Miller, H Campbell
Journal: BMJ (1980)

One hundred and seventy-four women who had previously had a child with a neural-tube defect were assessed retrospectively on the quality of their diets during the first trimester of that pregnancy, between pregnancies, and during the first trimester of other pregnancies. They were then studied prospectively during the first trimester of 186 following pregnancies and the outcome of these was recorded. One hundred and three women (with 109 pregnancies) were given dietary counselling before the pregnancy, the remaining 71 (with 77 pregnancies) not being counselled. Seventy-eight (72%) of the counselled women improved their diet compared with only nine (12%) of the uncounselled women. The difference was significant (p < 0.001). There were three recurrences of neural-tube defects in the counselled women (3%) and five recurrences in the uncounselled (7%). Although this difference was not significant, the relative risk in the counselled group was reduced to less than half of that in the uncounselled group. All eight recurrences occurred in the 45 pregnancies in women taking poor diets (18%), whereas there were no recurrences in the 141 other pregnancies. This difference is significant (p < 0.001). It is concluded that women receiving adequate diets have a lower incidence and recurrence of fetal neural-tube defects than women receiving poor diets and that dietary counselling may be effective in reducing the incidence of fetal neural-tube defects.
Tumor Invasion and Metastasis Initiated by mir-106b in Breast Cancer by Targeting BRMS1 and RB.
Authors: S. Pan, F. Yu, C. Gong, E. Song
Journal: Cancer Research (2009)

Abstract Background: MicroRNAs (miRNAs) are noncoding RNAs that have recently been demonstrated to have an important role in tumor metastasis. Mir-106b family is reported to promote the proliferation of cancer as an oncogene. However, whether mir-106b has roles in breast cancer metastasis and EMT remains unknown. Therefore, functional characterization of mir-106b in breast cancer cells would potentially facilitate our understanding of the development of breast cancer.Methods: Mir-106b expression and location in primary breast cancer samples from patients with metastasis were compared to the samples without metastasis by in situ hybridization analysis. Differentially expressed miRNAs in MDA-MB-231 breast cancer cell line were quantified by qRT-PCR and Northern Blot followed by scratch assays, migration assay, Boyen chamber assay and invasion assay to determine the significance of mir-106b in metastasis. Lentivirus-mediated miRNA transduction was used to determine the significance of mir-106b function. Target scan and luciferase reporter assay were used to identify the targets of mir-106b. Mir-106b targets' gene expression (BRMS1 and RB) was determined by qRT-PCR and western blot. The expression of E-cadherent by immunofluorescence and Western Blot were used to determine the regulation of mir-106b on the effect of TGF- β induced EMT.Results: Mir-106b was dramatically increased in primary breast cancer samples from patients with metastasis compared to the samples without metastasis, which is negatively correlated with patients' prognosis. MDA-MB-231 cells transfected with lentivirus-mir106b had a higher ability of invasion and migration. Conversely, transfecting mir-106b ASO into MDA-MB-231 cells decreased the invasion and migration ability in vitro. Silencing BRMS1 (breast cancer metastasis suppressor 1) and RB (retinoblastoma), which were proved to be new targets of mir-106b by luciferase assay, showed the similar results with mir-106b over-expressing. Furthermore, the expression of mir-106b in MCF10A cells was increased during TGF-βinduced EMT, while TGF-β-induced EMT was inhibited in MCF10A cells transfected with mir-106b ASO. Furthermore, we found that mir106b-expressing MDA-MB-231 cells gave rise to more tumors and metastasized more frequently in vivo.Conclusion: mir-106b can promote breast cancer invasion and metastasis by targeting BRMS1 and RB. Mir-106b mediates TGF-β-induced EMT, which is an early process of tumor metastasis. Therefore, mir-106b may be an effective maker to predict prognosis of breast cancer patients, and a new targets to treat breast cancer. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 6157.
774 SUBSTITUTION OF A CONSERVED AMINO ACID IN THE TRANSMEMBRANE DOMAIN OF E2 CONFERS RESISTANCE TO A NOVEL SMALL-MOLECULE INHIBITOR OF HCV ENTRY
Authors: G.A. Coburn, D.N. Fisch, S. Moorji, J.D. Murga, J.-M. de Muys, D. Paul, A.Q. Han, Y. Rotshteyn, D. Qian, P.J. Maddon, W.C. Olson
Journal: Journal of Hepatology (2011)
Estrogen and Postmenopausal Osteoporosis
Authors: E. G. Lufkin
Journal: Annals of Internal Medicine (1993)

Letters15 January 1993Estrogen and Postmenopausal OsteoporosisE. G. Lufkin, MD and B. Lawrence Riggs, MDE. G. Lufkin, MDSearch for more papers by this author and B. Lawrence Riggs, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-2-199301150-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We appreciate Dr. Gordan's comments, particularly because of his outstanding contributions to this area during the last 30 years. Although our study was not designed to evaluate the effects of progestins on lipids and bone density or to evaluate the contribution of calcium intake to preservation of bone mass, we agree in principle with Dr. Gordan's views.Dr. McGivney is correct that several factors may impede photon penetration and spuriously increase the value of spine bone mineral density as assessed by dual photon absorptiometry. However, we feel that compression fractures of lumbar vertebrae did not skew our results ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1993Volume 118, Issue 2Page: 155-156KeywordsBone densityEstrogensExerciseHysterectomyLipidsOsteoporosisPhoton absorptiometryRegression analysisSpineVertebrae ePublished: 15 August 2000 Issue Published: 15 January 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...