tbuckley/cabot-search huggingface dataset:
The Collagen Receptor Endo180 (CD280) Is Expressed on Basal-like Breast Tumor Cells and Promotes Tumor Growth <i>In vivo</i>
Authors: Dirk Wienke, Gareth C. Davies, Damian A. Johnson, Justin Sturge, Maryou B.K. Lambros, Kay Savage, Somaia Elbauomy Elsheikh, Andrew R. Green, Ian O. Ellis, David Robertson, Jorge S. Reis-Filho, Clare M. Isacke
Journal: Cancer Research (2007)

Abstract Tumor cell invasion into the surrounding stroma requires increased cell motility and extensive remodeling of the extracellular matrix. Endo180 (CD280, MRC2, urokinase-type plasminogen activator receptor-associated protein) is a recycling endocytic receptor that functions in both these cellular activities by promoting cell migration and uptake of collagens for intracellular degradation. In the normal breast, Endo180 is predominantly expressed by stromal fibroblasts. The contrary observation that Endo180 is expressed on epithelial tumor cell lines that display a high invasive capacity suggested that up-regulation of this receptor may be an associated and functional component in the acquisition of a more aggressive phenotype by tumor cells in vivo. Here, we show that high levels of Endo180 are found in a subset of basal-like breast cancers and that this expression is an independent prognostic marker for shorter disease-free survival. Two potential mechanisms for Endo180 up-regulation were uncovered. First, it was shown that Endo180 can be transcriptionally up-regulated in vitro following transforming growth factor-β treatment of breast cancer cells. Second, a proportion of Endo180+ tumors were shown to have Endo180 gene copy number gains and amplifications. To investigate the functional consequence of Endo180 up-regulation, MCF7 cells transfected with Endo180 were inoculated into immunocompromised mice. Expression of wild-type Endo180, but not an internalization-defective Endo180 mutant, resulted in enhanced tumor growth together with a reduction in tumor collagen content. Together, these data argue that elevated expression of this receptor in tumor cells could have important consequences in subsets of basal-like carcinomas for which there is a current lack of effective treatment. [Cancer Res 2007;67(21):10230–11]
Programmed death 1 expressing regulatory T cells in vitiligo
Authors: E.H. Kemp
Journal: British Journal of Dermatology (2015)

Journal Article Programmed death 1 expressing regulatory T cells in vitiligo Get access E.H. Kemp E.H. Kemp Department of Human Metabolism University of Sheffield Sheffield S10 2RX U.K https://orcid.org/0000-0002-0313-8916 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 4, 1 April 2015, Pages 847–848, https://doi.org/10.1111/bjd.13595 Published: 01 April 2015
Pregnant jogger: what a record!
Authors: Milan Korcok
Journal: JAMA (1981)

Maternity jogging clothes are not yet standard issue in most sports stores, but if more women copy one 36-year-old mother who continued her 6.4 km (4 mile) per day running program right up to the day before bearing her seventh child—and then walked the distance on the day of the birth—there may soon be a whole new line of designer togs on the market. The mother, whose case was reported at the annual meeting of the American College of Sports Medicine (ACSM) in Bal Harbour, Fla, was one of a group of pregnant women being tested for aerobic fitness by a team from the Human Performance Research Laboratory and the College of Nursing's division of midwifery at the University of Utah, Salt Lake City. Originally, the program included only pregnant women for whom swimming exercises were prescribed during their last trimester. The intent was to measure any physiological changes occurring
US health department recovers $4bn through antifraud action
Authors: J. H. Tanne
Journal: BMJ (2011)

The US Department of Health and Human Services and the Department of Justice announced on Monday 24 January that the government’s healthcare fraud prevention and enforcement efforts had recovered more than $4bn (€2.5bn; $2.9bn) in the 2010 fiscal year.

The money came from drug companies, hospitals, doctors’ offices, nursing homes, and other healthcare providers that had cheated the government. It was “the highest annual amount ever recovered from people who tried to defraud seniors and taxpayers,” the departments said in a joint statement. 

The $4bn had been stolen from federal healthcare programmes and was returned to Medicare, which provides health insurance for elderly people, the Treasury, and other …
Effect of Theophylline on the Proportion and Function of T‐Suppressor Cells in Asthmatic Children
Authors: N. Lahat, E. Nir, L. Horenstien, A. A. Colin
Journal: Allergy (1985)

T‐cell subpopulations and their function were studied in asthmatic children with or without theophylline therapy. A decreased proportion and function of theophylline‐sensitive T‐suppressor cells was found in fresh peripheral blood of asthmatic children. Following peripheral blood mononuclear cells (PBMC) incubation in theophylline‐free medium, the proportion of theophylline‐sensitive T‐cells in asthmatic children treated with theophylline was elevated to normal values. However, their suppressive effect on control lymphocyte proliferation was unchanged.
Myocardial Uptake of <sup>99m</sup> Tc-Tetrofosmin, Sestamibi, and <sup>201</sup> Tl in a Model of Acute Coronary Reperfusion
Authors: Norio Takahashi, Christopher P. Reinhardt, Robin Marcel, Jeffrey A. Leppo
Journal: Circulation (1996)

To investigate whether tetrofosmin uptake is affected by myocardial viability as has been noted for 201Tl and sestamibi, we analyzed the initial and delayed distribution patterns of tetrofosmin in a rat coronary artery occlusion-reperfusion model.Animals were intubated and ventilated, and their arterial pressures were monitored. A left thoracotomy was performed. After 1-hour occlusion and 1-hour reperfusion of a major branch of the circumflex artery, 201Tl and either tetrofosmin or sestamibi were injected intravenously. Radiolabeled microspheres were used to document the area at risk and reperfusion. Five minutes or 1 hour after administration of the diffusible tracers, the animals were killed. Tracer distribution was determined by use of segmental tissue analysis, and tissue viability was determined by use of histochemical staining. Both the initial and delayed retention of tetrofosmin were sensitive to myocardial viability, as shown by significantly lower uptake (30 +/- 14%) and retention (24 +/- 12%) of tetrofosmin in the nonviable segments compared with the viable segments. In addition, the initial myocardial distribution of tetrofosmin was similar to that noted for 201Tl, but after 1 hour of tracer circulation, the tetrofosmin tissue distribution appeared unchanged compared with the initial regional blood flow distribution. This is in direct contrast to our present observations of significant 201Tl redistribution and some changes in sestamibi distribution as well.The clinical implication of these observations suggests that initial and delayed imaging after tetrofosmin administration would reflect both the initial regional blood flow pattern and myocardial viability.
Spread of lesions in Crohn's disease of the colon
Authors: F. Brahme, A. Wenckert
Journal: Gut (1970)

Spread of lesions in Crohn9s disease of the colon was closely followed in 20 cases, representing almost one quarter of a group of surgically treated patients. Such spread occurred most commonly in an aboral direction and was usually accompanied by an exacerbation of symptoms, although spread occasionally occurred during apparently quiescent periods.
Screening Early Embryos
Authors: Joan Stephenson
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Correcting the Oversupply of Specialists by Limiting Residencies for Graduates of Foreign Medical Schools
Authors: M E Whitcomb
Journal: New England Journal of Medicine (1995)

It is estimated that there will be an excess of approximately 165,000 specialist physicians in the United States in the year 2000.1,2 Consistent with these projections are anecdotal reports that physicians completing residency training in some specialties are having difficulty finding suitable professional opportunities and that the growth of managed care is adversely affecting established specialty practices in some regions.There is no consensus on how to address the problem of an oversupply of physicians. At issue are conflicting views on the appropriate roles of government and the market in restricting the supply of specialist physicians. Analysts who see . . .
191 Opposite post translational regulation of endothelial no synthase (ENOS) by heat shock protein 90 and caveolin in liver and lungs from rats with hepatopulmonary syndrome
Authors: C.M. Pastor, R. Quadri, A. Hadengue, B. Cikirikcioglu, E. Schiffer, J. Bourquin, D. Morel, J.L. Frossard
Journal: Journal of Hepatology (2006)
Abstract 4677: Slug is a potential target to restore transforming growth factor-β mediated apoptosis in lung cancer cells
Authors: Ajaya Kumar Reka, Moloy Goswami, Himabindu Kurapati, Viritha Kaza, Jun Chen, Venkateshwar G Keshamouni
Journal: Cancer Research (2012)

Abstract Transforming growth factor-β (TGFβ) inhibits carcinogenesis at early stages by inhibiting cell growth and inducing apoptosis. Cancer cells acquire resistance to TGFβ induced apoptosis and divert the TGF-β signaling to stimulate tumor promoting processes such as Epithelial-Mesenchymal-Transition (EMT), immunosuppression and angiogenesis. Hence, the identification of molecular targets/ pathways enabling cancer cells to overcome TGFβ-mediated apoptosis is critical for exploiting tumor suppressive functions of TGFβ for therapy. We have identified slug (snai2), a zinc-finger transcription factor, as a critical regulator of TGF-β mediated apoptosis in lung cancer cells. In EMT models of lung cancer slug is up-regulated by several fold upon TGFβ treatment. Knock down of Smad 3 or Smad 4, but not Smad 2, completely abrogated the TGF-β induced up-regulation of Slug. Chromatin immunoprecipitation analysis revealed increased occupancy of Smad 3 to the slug promoter on TGFβ treatment indicating slug might be a direct target gene of Smad 3. Slug is often described as a potent E-cadherin suppressor and an important regulator of EMT along with other E-box proteins. In contrast siRNA knock-down of slug (slug KD) in lung cancer cells did not prevent TGFβ induced E-cadherin suppression or acquisition of mesenchymal markers such as N-cadherin, vimentin and fibronectin; instead lead to increased cell death. Slug KD cells on TGFβ treatment underwent apoptosis through the typical apoptosis cascade characterized by increased annexin-v staining and caspase-3 activation. This apoptotic cell death is abrogated by inhibitors of caspase-3 and caspase-9. Inhibition of caspase-8, an initiator of extrinsic apoptotic pathway or siRNA knockdown of RIP1 that promotes necroptosis did not inhibit the death of TGFβ treated slug KD cells. Together these finding suggests slug KD results in cell death via intrinsic apoptosis pathway in response to TGFβ. This study indicates slug induction during EMT allows cancer cells to escape from apoptotic functions of TGFβ and might function as a critical regulatory switch to shift TGFβ role from tumor suppressor to tumor promoter. Thus slug inhibition might serve as a potential mechanism to reinstate the apoptotic functions of TGFβ in lung cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4677. doi:1538-7445.AM2012-4677
Leaders Attempt a Long-term Prognosis for the Health of American Medicine
Authors: Marsha F. Goldsmith
Journal: JAMA (1988)

"MEDICINE FOR THE 21st Century" is emblazoned over the entrance of the Annenberg Center in Rancho Mirage, Calif, making the palmy high-tech oasis an apt location for a recent conference on that theme. More than 100 leaders of medicine, industry, and government were invited to consider how future health care needs of the American people will be met, given a present state of affairs many see as threatening the very foundation of the system—biomedical research and technological innovation and development. At the conference, cosponsored by the American Medical Association (AMA), the Annenberg Center for Health Sciences at Eisenhower, and Pfizer, Inc, a major concern was that diminished financial support for basic research is driving prospective scientists into other careers and is making the United States less competitive internationally. At the same time, intensive challenges to long-held US supremacy in biotechnology and medicine are starting to come from western Europe and
Measurement of cytosolic calcium using 19F NMR.
Authors: E Murphy, L Levy, B Raju, C Steenbergen, J T Gerig, P Singh, R E London
Journal: Environmental Health Perspectives (1990)

Fluorine-19 nuclear magnetic resonance (NMR) studies of cells and perfused organs loaded with fluorinated ion chelators represent a new approach to determining cytosolic free calcium levels in situ. The molecular basis for this approach and the relative advantages and disadvantages of the NMR technique are discussed in this paper. Results obtained on perfused normoxic and ischemic rat hearts are presented, indicating that ischemia is associated with an elevation in the level of cytosolic free calcium before the onset of irreversible cell injury. The results are therefore consistent with this elevation playing a causative role in the mediation of myocardial cell injury resulting from ischemia.
PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties
Authors: M. Amine Bouhlel, Bruno Derudas, Elena Rigamonti, Rébecca Dièvart, John Brozek, Stéphan Haulon, Christophe Zawadzki, Brigitte Jude, Gérard Torpier, Nikolaus Marx, Bart Staels, Giulia Chinetti-Gbaguidi
Journal: Cell Metabolism (2007)
Other method for adjustment of multiple testing exists
Authors: M. Aickin
Journal: BMJ (1999)

EDITOR—Perneger's paper on Bonferroni adjustments consists almost entirely of errors.1 He states that the Bonferroni adjustments are concerned with the wrong hypothesis and that the two groups are identical on all 20variables (the universal null hypothesis). This misses the main point of multiple test adjustments.

Similarly he says, “If one or more of the 20P values is less than 0.00256…we can say that the two groups are not equal for all 20variables, but …
Gallium Uptake in a Paraplegic Patient with Bilateral Lower Extremity Fat Necrosis
Authors: FRANCINE M. WOLPE, S K C CHANDARLAPATY, JORGE D. JACOBI, MARILYN WELLS, STEPHEN ROSENTHAL
Journal: Clinical Nuclear Medicine (1989)

A case of soft tissue gallium uptake in a paraplegic patient with biopsy-proven fat necrosis of both lower extremities is presented. Superficial bilateral lower extremity uptake has not been previously reported in the imaging literature, nor has fat necrosis in this unusual distribution been reported in the spinal cord population.
NON-SPECIFIC CHOLINESTERASE IN SPECIALIZED SENSORY NERVE-ENDINGS OF HUMAN GENITAL SKIN.
Authors: HARRY J. HURLEY
Journal: British Journal of Dermatology (1958)

Journal Article NON‐SPECIFIC CHOLINESTERASE IN SPECIALIZED SENSORY NERVE‐ENDINGS OF HUMAN GENITAL SKIN. Get access HARRY J. HURLEY, M.D., D.Sc. (Med.). HARRY J. HURLEY, M.D., D.Sc. (Med.). Dept. of Dermatology, School of Medicine, and the Dept. of Physiology and Pharmacology, Graduate School of Medicine, University of Pennsylvania, Philadelphia, Penna Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 70, Issue 8-9, 1 August 1958, Pages 284–287, https://doi.org/10.1111/j.1365-2133.1958.tb13340.x Published: 01 August 1958
The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
Authors: Walter L. Miller, Richard J. Auchus
Journal: Endocrine Reviews (2011)

Steroidogenesis, the processes by which cholesterol is converted to steroid hormones, involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic enzymes are either forms of cytochrome P450 or are hydroxysteroid dehydrogenases. The P450s may be either Type 1, in mitochondria, or Type 2, in the endoplasmic reticulum; these two types differ in their electron-transfer redox partners as well as in their cellular locations. Hydroxysteroid dehydrogenases may be either shortchain dehydrogenases or aldo-keto reductases, which differ in their structures and catalytic mechanisms. Recent work has identified new enzymes, co-factors and protein modifications, and has described new pathways of steroidogenesis and new sites of steroid synthesis. Thus steroidogenesis is not confined to the adrenals and gonads, and involves more than the production of aldosterone, cortisol and sex steroids. We review the enzymes, factors and pathways of human steroidogenesis and the diseases resulting from their mutations. Steroidogenesis entails processes by which cholesterol is converted to biologically active steroid hormones. Whereas most endocrine texts discuss adrenal, ovarian, testicular, placental, and other steroidogenic processes in a gland-specific fashion, steroidogenesis is better understood as a single process that is repeated in each gland with cell-type-specific variations on a single theme. Thus, understanding steroidogenesis is rooted in an understanding of the biochemistry of the various steroidogenic enzymes and cofactors and the genes that encode them. The first and rate-limiting step in steroidogenesis is the conversion of cholesterol to pregnenolone by a single enzyme, P450scc (CYP11A1), but this enzymatically complex step is subject to multiple regulatory mechanisms, yielding finely tuned quantitative regulation. Qualitative regulation determining the type of steroid to be produced is mediated by many enzymes and cofactors. Steroidogenic enzymes fall into two groups: cytochrome P450 enzymes and hydroxysteroid dehydrogenases. A cytochrome P450 may be either type 1 (in mitochondria) or type 2 (in endoplasmic reticulum), and a hydroxysteroid dehydrogenase may belong to either the aldo-keto reductase or short-chain dehydrogenase/reductase families. The activities of these enzymes are modulated by posttranslational modifications and by cofactors, especially electron-donating redox partners. The elucidation of the precise roles of these various enzymes and cofactors has been greatly facilitated by identifying the genetic bases of rare disorders of steroidogenesis. Some enzymes not principally involved in steroidogenesis may also catalyze extraglandular steroidogenesis, modulating the phenotype expected to result from some mutations. Understanding steroidogenesis is of fundamental importance to understanding disorders of sexual differentiation, reproduction, fertility, hypertension, obesity, and physiological homeostasis.
Nail bed lichen planus associated with onychopapilloma
Authors: B. Richert, M. Iorizzo, A. Tosti, J. André
Journal: British Journal of Dermatology (2007)

Journal Article Nail bed lichen planus associated with onychopapilloma Get access B. Richert, B. Richert Department of Dermatology, University of Liège, 45 quai Kurth, 4020 Liège, Belgium *Department of Dermatology, University of Bologna, Bologna, Italy †Department of Dermatology, Free University of Brussels, Brussels, Belgium E‐mail: bertrand.richert@skynet.be Search for other works by this author on: Oxford Academic Google Scholar M. Iorizzo, M. Iorizzo Department of Dermatology, University of Liège, 45 quai Kurth, 4020 Liège, Belgium *Department of Dermatology, University of Bologna, Bologna, Italy †Department of Dermatology, Free University of Brussels, Brussels, Belgium E‐mail: bertrand.richert@skynet.be Search for other works by this author on: Oxford Academic Google Scholar A. Tosti, A. Tosti Department of Dermatology, University of Liège, 45 quai Kurth, 4020 Liège, Belgium *Department of Dermatology, University of Bologna, Bologna, Italy †Department of Dermatology, Free University of Brussels, Brussels, Belgium E‐mail: bertrand.richert@skynet.be Search for other works by this author on: Oxford Academic Google Scholar J. André J. André Department of Dermatology, University of Liège, 45 quai Kurth, 4020 Liège, Belgium *Department of Dermatology, University of Bologna, Bologna, Italy †Department of Dermatology, Free University of Brussels, Brussels, Belgium E‐mail: bertrand.richert@skynet.be Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue 5, 1 May 2007, Pages 1071–1072, https://doi.org/10.1111/j.1365-2133.2007.07797.x Published: 01 May 2007