tbuckley/cabot-search huggingface dataset:
The Hydrocephalus Association
Authors: J. Luder
Journal: BMJ (1964)

BRiTisH 877 1,400 units the patient was having strong con- tractions lasting 50-60 seconds every 90 seconds.The remnants of the, tablets were removed.Pethilorfan (pethidine hydrochloride and levallorphan tartrate), 150 mg., was given intra- muscularly.The contractions continued at the same frequency, the second stage being com- plete 50 minutes later.The foetal heart rate was regular.The baby cried lustily on arrival.The secundines were delivered complete in 10 minutes.Steady vaginal bleeding continued in spite of a well-contracted uterus and further ergometrine.The patient felt faint and
336 Combination therapy of interferon-α-2B with ribavirin decreases the content of 20:5N-3 polyunsaturated fatty acid of erythrocyte membrane phospholipid in chronic hepatitis C patients
Authors: K HINO, A KITASE, Y HARA, Y YAMAGUCHI, Y OTA, A NAGAI, T SASAGAWA, M OKITA, T FURUTANI, R FENYU
Journal: Hepatology (2003)
Early detection of cysteine rich protein 61 (CYR61, CCN1) in urine following renal ischemic reperfusion injury
Authors: Yasunari Muramatsu, Michiko Tsujie, Yukimasa Kohda, Bertha Pham, Alan O. Perantoni, Hong Zhao, Sang-Kyung Jo, Peter S.T. Yuen, Leonard Craig, Xuzhen Hu, Robert A. Star
Journal: Kidney International (2002)
Basal-Cell Carcinoma
Authors: Salvatore J. Scialla
Journal: JAMA (1976)

TOPICAL fluorouracil has been effective for the management of superficial basal-cell carcinoma. This topical chemotherapy can also unmask otherwise undiagnosable lesions.<sup>1</sup>A patient experienced an inflammatory reaction around a skin lesion while taking intravenous fluorouracil, which prompted us to perform a biopsy of the area. <h3>Report of a Case</h3> A 56-year-old man, after a partial colectomy for adenocarcinoma of the sigmoid colon in 1971, experienced anorexia and weight loss in September 1974. He was found to have liver metastasis and was given floxuridine (FUDR) by hepatic artery infusion. After this infusion, maintenance therapy with fluorouracil, 1 gm intravenously per week, was started. Following the third dose of fluorouracil, he experienced diarrhea, stomatitis, a facial skin eruption, and intense inflammation and pruritus involving a previously asymptomatic, inconspicuous papular skin lesion on the chest. Physical examination showed a macular erythematous facial eruption. In addition, a prominent nodular ulcerative lesion not noted
Depression in Alcoholics: Implications for Treatment
Authors: Bick Wanck
Journal: JAMA (1985)

<h3>To the Editor.—</h3> Patients who are chronic alcoholics, who are in alcohol withdrawal, or who have recently consumed excessive amounts of alcohol often complain of depressed mood, anxiety, and feelings of hopelessness and decreased self-worth. They have insomnia, nightmares, anorexia, decreased interest in sex, and suicidal ideation. Keller et al<sup>1</sup>have advocated that treatment for depression accompanying alcoholism "should begin as soon as possible after the onset of depression symptoms." Keeler et al<sup>2</sup>pointed out that the occurrence of symptoms of depression in the alcoholic has, in the past, "led to the use of antidepressant drugs as treatment for alcoholism independent of any specific evidence of depression." Other writers give convincing evidence that the use of antidepressants in alcoholics should not be undertaken until the patient has been evaluated after a period of abstinence and that such treatment is often unnecessary. Weingold et al<sup>3</sup>noted in their
Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus
Authors: Sulaiman M Al-Mayouf, Asma Sunker, Reem Abdwani, Safiya Al Abrawi, Fathiya Almurshedi, Nadia Alhashmi, Abdullah Al Sonbul, Wafaa Sewairi, Aliya Qari, Eiman Abdallah, Mohammed Al-Owain, Saleh Al Motywee, Hanan Al-Rayes, Mais Hashem, Hanif Khalak, Latifa Al-Jebali, Fowzan S Alkuraya
Journal: Nature Genetics (2011)
ASSESSMENT OF STROKE RISK IN ATRIAL FIBRILLATION: PHYSICIAN ESTIMATE VERSUS CHADS2 RISK SCORE: RESULTS FROM ORBIT-AF
Authors: Benjamin Steinberg, Sunghee Kim, Laine Thomas, Rosalia Blanco, Jack Ansell, Gregg Fonarow, Bernard Gersh, Elaine Hylek, Kenneth Mahaffey, Peter Kowey, Daniel Singer, Paul Chang, Jonathan Piccini, Eric Peterson
Journal: Journal of the American College of Cardiology (2014)
Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome
Authors: Francesco Parlati, Susan J. Lee, Monette Aujay, Erika Suzuki, Konstantin Levitsky, James B. Lorens, David R. Micklem, Paulina Ruurs, Catherine Sylvain, Yan Lu, Kevin D. Shenk, Mark K. Bennett
Journal: Blood (2009)
Dynamics of Antibiotic Prescribing for Children
Authors: Michael E. Pichichero
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diet and its relation to coronary heart disease and death in three populations.
Authors: T Gordon, A Kagan, M Garcia-Palmieri, W B Kannel, W J Zukel, J Tillotson, P Sorlie, M Hjortland
Journal: Circulation (1981)

Baseline 24-hour dietary recalls from 16,349 men ages 45-64 years who had no evidence of coronary heart disease (CHD) were obtained in three prospective studies: the Framingham Study (859 men), the Honolulu Heart Study (7272 men) and the Puerto Rico Heart Health Program (8218 men). These men were followed for up to 6 years for the first appearance of CHD or death. Men who had a greater caloric intake or a greater caloric intake per kilogram of body weight were less likely to develop CHD manifest as myocardial infarction (MI) or CHD death, even though men of greater weight were more likely to develop CHD. This may reflect the benefit of greater physical activity. Men who consumed more alcohol were less likely to develop CHD, but more likely to die of causes other than CHD, particularly in the Honolulu study. In the Honolulu and Puerto Rico studies, but not in the Framingham study, men who consumed more starch were less likely to develop MI or CHD death. There was an inverse relation between starch intake and serum cholesterol, but it was too weak to explain fully the inverse starch-CHD association. There was also no evidence that the inverse relation between starch intake and incidence of CHD in the Honolulu and Puerto Rico studies was an indirect result of differences in fat intake. While the findings suggest additional areas for research, none of them would lead to an alteration of currently recommended preventive diets that emphasize lowering fat intake, because in isocaloric diets the logical way to balance a decreased fat intake is to increase the consumption of foods containing starch.
Ultrasound May Markedly Improve Cancer Detection in Dense Breasts
Authors: Thomas C. Jefferson
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mobilization of Antioxidant Vitamin Pools and Hemodynamic Function After Myocardial Infarction
Authors: Vince P. Palace, Mike F. Hill, Firoozeh Farahmand, Pawan K. Singal
Journal: Circulation (1999)

Although most previous studies have attempted to correlate plasma concentrations of vitamins with specific cardiovascular end points, metabolic considerations suggest that changes in myocardial tissue and storage organs may be better indicators of myocardial oxidative stress.Rats fed commercial chow or a diet enriched with vitamin E for 2 weeks were subjected to either a surgical myocardial infarction (MI) or a sham procedure. Rats were hemodynamically assessed 16 weeks after surgery, and their heart, liver, kidney, and plasma were analyzed for antioxidant vitamins E (tocopherol) and A (retinol and total retinyl esters). At 16 weeks, MI rats on a control diet showed depressed peak systolic and elevated diastolic pressures in both right and left ventricles compared with their sham controls. Plasma concentrations of vitamins E and A in MI rats were not different from sham controls fed the same diet. However, concentrations of vitamin E in left ventricle and liver and of vitamin A in liver (retinol) and kidney (retinyl esters) were decreased in rats with MI compared with the sham controls. Vitamin E supplementation improved hemodynamic function in rats with MI and increased plasma, myocardial, liver, and kidney concentrations of vitamin E. The vitamin E diet also prevented the loss of total retinyl esters from the kidney but not of retinol from the liver in MI rats.Dietary supplements of vitamin E can sustain better cardiac function subsequent to MI. Antioxidant vitamin levels in the myocardium or in storage organs and not in plasma may be better indicators of myocardial oxidative stress.
Coronavirus Genomic-Sequence Variations and the Epidemiology of the Severe Acute Respiratory Syndrome
Authors: Stephen K.W. Tsui, Stephen S.C. Chim, Y.M. Dennis Lo
Journal: New England Journal of Medicine (2003)

To the Editor: Our teaching hospital was the site of a major outbreak of the severe acute respiratory syndrome (SARS).1 We sequenced viral isolates cultured from clinical specimens from seven patients with SARS in this outbreak. The viral isolates were from passage 1 of the SARS coronavirus cultured in Vero cells.2 We obtained the complete genomic sequence of the virus cultured from the mother of the index patient in this hospital outbreak (isolate Su-10, GenBank accession number AY282752).1 The mother's symptoms had begun on March 5, 2003; she died on April 13, 2003. We also sequenced the spike glycoprotein gene . . .
How Islam changed medicine: Al-Nafis, Servetus, and Colombo
Authors: Giles N Cattermole
Journal: BMJ (2006)

Good quality monitoring is crucial for informed choiceEditor-In accordance with the patient choice scheme, all 303 primary care trusts in England were obliged from January 2005 to offer patients a choice of at least two providers for cataract surgery. 1 The scheme allows patients to be involved in how, where, and when they are treated.Providers can be NHS trusts, diagnostic and treatment centres, or independent sector providers from the UK or overseas.By February 2005 13 000 extra operations had already been performed under the independent sector treatment programme. 2However, concern was raised about variations in clinical safety between different providers. 3 We sent a postal questionnaire to the leaders of patient choice for each of the primary care trusts in England asking how they monitor the quality of care from their providers.The table shows the replies from 125 trusts.The quality monitoring of providers by primary care trusts is poorly structured and variable.Who then should monitor standards and what variables should they use?Traditionally, NHS providers have used audit and clinical governance to measure their performance.Should it now be the role of the Strategic Health Authority, the provider, or the purchaser in the form of primary care trusts to monitor the product offered to the patient?Information technology exists to collect accurate data about adverse events in addition to visual acuity and refractive outcomes.The public expect that safe cataract care should be commissioned for them, 4 and robust methods of monitoring need to be agreed and implemented so that patients can make a truly informed choice.These decisions need to be made not only for cataract surgery but also for other elective procedures that will increasingly be made available to patients through the patient choice scheme.
Epigenetics and chronic lymphocytic leukemia
Authors: Margaret K. Yu
Journal: American Journal of Hematology (2006)

The DNA methylation level in patients with chronic lymphocytic leukemia is generally lower than healthy individuals. Although DNA methylation is globally decreased, regional hypermethylation of gene promoters leads to gene silencing. Many of these genes have tumor suppressor phenotypes. Unlike mutations or deletions, hypermethylation is potentially reversible after inhibition with DNA methylation modulators. Myelodysplastic syndrome has been a model disease in which treatment of patients results in demethylation of specific genes. The story in patients with chronic lymphocytic leukemia is slowly unraveling as epigenetic modifications likely also play an important role. Ongoing clinical trials correlating clinical response to gene expression after treatment with DNA methylation inhibitors will ultimately allow us to better risk stratify and predict the subgroup of patients who will benefit from treatment with this class of drugs. Am. J. Hematol., 2006, © 2006 Wiley-Liss, Inc.
Medical Devices: Sophisticated Legislation after Long Struggle
Authors: William J. Curran
Journal: New England Journal of Medicine (1976)

The Federal Food and Drug Administration (FDA) has finally achieved enactment of comprehensive legislation that will strictly regulate the growing medical-devices industry. The battle has taken over 10 years. Each year the FDA tried again to expand its jurisdiction from drugs, cosmetics and food to medical equipment and devices, everything from tongue depressors to heart-lung machines, and the industry lined up the opposition. Leading physicians in medical practice and clinical research were in the front lines of the witnesses objecting to the bills, year after year. The primary concern of the medical witnesses was that federal regulation would substantially delay . . .
Nature of Heroin Dependence
Authors: Peter Beaconsfield
Journal: JAMA (1974)

To the Editor.—  The problem of treating heroin addicts continues to go unresolved. The supporters and detractors of methadone maintenance programs produce more and more evidence to support their divergent views. The sobering fact remains that we are no nearer success in the treatment of heroin addiction than we were a decade ago.  The small quantity of heroin found in the average illegal bag is insufficient for most addicts to develop true physical dependence. 1,2 The symptoms and signs of withdrawal as described in generations of textbooks are not primarily related to the pharmacological effects of the drug, or the lack of it, but to the patient's innate fear of not getting his next fix. When true physical symptoms develop, which take about 72 hours to become pronounced, we find evidence to suggest that they are associated with an increase in detoxifying chemicals in the liver that accumulate in the
Pseudomonas Septicemia and Splenectomy
Authors: M. G. RAJURKAR
Journal: Annals of Internal Medicine (1974)

Comments1 May 1974Pseudomonas Septicemia and SplenectomyM. G. RAJURKAR, M.B.M. G. RAJURKAR, M.B.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-5-675_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Fatal or life-threatening infections in asymptomatic and symptomatic splenectomised patients with Hodgkin's disease have been reported (1-4). The etiological agents in the reported cases werePneumococcusorHemophilus influenzae(1-4). Fatal Pseudomonas septicemia has been reported in one case of nonHodgkin's lymphoma (5). The following case report is probably the first one of fatal pseudomonas septicemia in a symptomatic splenectomised patient with Hodgkin's disease. It is impossible to attribute this infection to a single factor; it could be caused by [1] impaired cellular immunity, [2] chemotherapy, [3] an asplenic state, or [4] a combination of all these...References1. NIXONAISENBERG DA: Fatal Hemophilus influenzae sepsis in an asymptomatic splenectomized Hodgkin's disease patient. Ann Intern Med 77:69-71, 1972 LinkGoogle Scholar2. STIVERSHARARKENDRICK GRM: Bacterial risk in staging splenectomy (letter). Ann Intern Med 76:670, 1972 LinkGoogle Scholar3. RAVRYMALDONADOVÉLEZ-GARCÍA MNE: Serious infections after splenectomy for the staging of Hodgkin's disease. Ann Intern Med 77:11-14, 1972 LinkGoogle Scholar4. ROSENBERG S: A critique of the value of laparotomy and splenectomy in the evaluation of patients with Hodgkin's disease. Cancer Res 31:1737-1740, 1971 MedlineGoogle Scholar5. CONSTANTOULAKISECONOMOPOULOSCONSTANTOPOULOS MPA: Infections after splenectomy (letter). Ann Intern Med 78:780-781, 1973 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Oncology Variety Children's Hospital Miami, Florida 33155 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySplenectomy and Sudden DeathInfections in Splenectomized Patients: A Study of 131 PatientsCase 27-1975 1 May 1974Volume 80, Issue 5Page: 675-675KeywordsHaemophilus influenzaeHodgkin lymphomaImmunityInfectious diseasesLymphomaPneumococcusPseudomonasPseudomonas infectionsSepsisSplenectomy Issue Published: 1 May 1974 PDF downloadLoading ...
Hemodynamic Characteristics of Chronic Experimental Neurogenic Hypertension in Unanesthetized Dogs
Authors: CARLOS M. FERRARIO, JAMES W. MCCUBBIN, IRVINE H. PAGE
Journal: Circulation Research (1969)

The hemodynamic changes accompanying experimental neurogenic hypertension due to sinoaortic denervation were measured in unanesthetized dogs for 3 weeks with chronically implanted arterial catheters and aortic flow transducers. Hypertension was modest, the average increase in mean arterial pressure being 31 ± 5 (SE) mm Hg. In about half of the dogs it was due predominantly to increase in cardiac output and in the others to increase in peripheral resistance; one factor or the other tended to maintain the hypertension in each dog throughout the experiments. Arterial pressure became extremely labile during the first few days after denervation and remained so during the entire experiment. This lability was closely correlated with environmental stimuli; rather minor distractions caused a sharp fall in pressure due variably to decrease in both cardiac output and peripheral resistance; greater distractions or physical activity caused a rise in pressure due usually to increase in peripheral resistance. Mean arterial pressures were higher when measured by transcutaneous puncture of a femoral artery, presumably because of the necessity of restraint and the discomfort associated with passage of a needle. Before sinoaortic denervation, arterial pressures fell to basal levels during sleep. After denervation, unexpectedly and for an undetermined cause, pressures rose to very high levels during sleep; the rises were consistently due to increase in peripheral resistance. Awakening was accompanied by a sharp fall in pressure and peripheral resistance.
Salt-sensitive hypertension: if only it were as simple as rocket science
Authors: Timothy L. Reudelhuber
Journal: Journal of Clinical Investigation (2003)

What? Salt and hypertension? Again? If your attention drifted and you haven’t been able to follow the debate for the last 30 years, I’d highly recommend reading the 1998 Science article appropriately entitled “The (political) science of salt” (1). Both the original article and the heated responses it generated are more entertaining than a ringside seat at a Saturday night wrestling match. Why can’t we agree on whether dietary salt is good or bad for people (or neither)? Some have suggested that the difficulty lies in the fact that the general population should be subclassified as salt “responders” and “non-responders”. Another possibility, strengthened by the work of Ni et al. (2) in this issue of the JCI, is that additional hormonal factors modulate our salt sensitivity, making it a moving target.
A VERY LARGE SALIVARY CALCULUS REMOVED FROM A PATIENT.
Authors: JULIAN J. CHISOLM
Journal: JAMA (1884)

Salivary calculi are not of very rare occurrence. A tumor under the tongue, on one side of the frenum, a dilated duct from the sub-maxillary gland full of fluid, and called ranula, might contain calcareous deposits. But very rarely have we the opportunity of reporting a calculus of such magnitude as the one which I extracted from the mouth of a patient two months since. I herewith append a report of the case: Mr. W., aged 73, consulted me for a glaucomatous trouble. During the consultation, he desired to know whether his defect of vision could be aggravated by a disease of long standing in the mouth. In inspecting this cavity, I found a large swelling under the tongue, on the right side of the frenum. It was a very prominent elevation on the floor of the buccal cavity, extending from the inner face of the chin toward ward the
Polymyalgia Rheumatica and Interspinous FDG Uptake on PET/CT
Authors: Human Adams, Pieter Raijmakers, Yvo Smulders
Journal: Clinical Nuclear Medicine (2012)

Polymyalgia rheumatica (PMR) is an inflammatory disease with macrophage infiltration and CD4+ T-lymphocytes-related mild synovitis commonly causing neck, shoulder, and hip stiffness in patients older than 50 years. Closely related to giant cell arthritis (GCA), PMR symptoms can be similar to rheumatoid arthritis. Erythrocyte sedimentation rate and C-reactive protein levels are elevated in >90% of cases. In 4 patients with PMR, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) demonstrates uptake in the shoulder and hip joints and also interspinous and supraspinous focal and diffuse uptake. We propose diffuse uptake may reflect ligament inflammation with focal uptake in adjacent interspinous bursitis.
TAKING COD LIVER OIL
Authors: William H. Block
Journal: JAMA (1924)

<h3>To the Editor:</h3> —The use of cod liver oil is limited because of its odor, its taste, and the fact that it "repeats" with so many patients. Some months ago, I prescribed it for a patient who protested, and just by chance I suggested that she eat half a banana immediately after taking the dose of oil. The result was remarkable and has enabled me to give this preparation in many instances in which I am sure it could never have been used otherwise.