tbuckley/cabot-search huggingface dataset:
Abstract 2422: The trimeric engineered fusion protein with CD154 peptide mimetic (OmpC-CD154p), induced apoptotic signaling in B-NHL cell lines mediated by caspase 3 and caspase 8 activation
Authors: Bernardo Martinez-Miguel, Melisa Martinez Paniagua, Sara Huerta-Yepez, Cesar Gonzalez-Bonilla, Mario Vega-Paredes, Otoniel Martinez-Maza, Benjamin Bonavida
Journal: Cancer Research (2010)

Abstract CD154 (CD40-ligand) is a critical transmembrane molecule with potent immune-stimulatory properties and is clinical applied in gene therapy for leukemia and lymphoma. The interaction between CD40, a member of the tumor necrosis factor superfamily, and its ligand CD154 is essential for the development of humoral and cellular immune responses. Selective inhibition or activation of this pathway forms the basis for the development of new therapeutics against immunologically-based diseases and malignancies. Engagement of CD40-CD154 induces activation and proliferation of B lymphocytes and triggers apoptosis of carcinoma and B lymphoma cells. Several clinical trials have been reported targeting CD40 in cancer patients using recombinant CD154, mAbs and gene therapy, which were well tolerated and resulted in objective tumor responses. In addition to these therapies, CD154 mimetics have been considered with the objective to augment and potentiate the direct cytotoxic anti-tumor activity and for better accessibility to tumor sites. This approach was developed by us and we hypothesized that the genetic engineering of a fusion protein containing a CD154 peptide mimetic additional to be trimeric may be advantageous in that it may have a better affinity to CD40 on B cell malignancies and trigger cell death. The fusion partner may be a carrier targeting other surface molecules expressed on the malignant cells. This hypothesis was tested by the development of a gene fusion of Salmonella typhi OmpC protein expressing the CD154 Trp140-Ser149 amino acid strand. This OmpC-CD154p fusion protein binds CD40 and triggers the CD40 expressing B cells. In this study, we demonstrate that OmpC-CD154p treatment inhibits cell growth and proliferation, on B-NHL cell lines Raji and Ramos. In addition, significant apoptosis was achieved and the extent of apoptosis was a function of the concentration used and time of incubation. The anti-tumor effect was specific as treatment with OmpC alone had no effect. OmpC-CD154p treatment induced activation of caspase 3 active and caspase 8. These findings establish the basis for the development of new fusion proteins specificity targeting the tumor cells directly and mechanism mediated by extrinsic pathway. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2422.
Detection of cardiac transplant rejection with radiolabeled lymphocytes.
Authors: S R Bergmann, R A Lerch, E M Carlson, J E Saffitz, B E Sobel
Journal: Circulation (1982)

To determine whether rejections of cardiac transplants could be detected specifically and non-invasively by lymphocytes labeled with indium-111 (111In), we studied 36 allogeneic and 14 isogeneic heterotopic cardiac transplants in rats. Allogeneic grafts accumulated autologous 111In-lymphocytes, detectable scintigraphically 24 hours after i.v. injection of the labeled cells. At the time of peak histologic rejection, the allogeneic grafts accumulated 92. +/- 4.8 times more activity than the native hearts (determined by well counting). The tissue-to-blood ratio in the rejecting transplants was 3.7 +/- 2.2; total uptake by the graft was 2.9 +/- 2.1% of the injected dose. Autoradiography confirmed that graft radioactivity was associated with labeled lymphocytes. In contrast, isogeneic grafts showed no signs of rejection and did not accumulate radioactivity. Because conventionally isolated and labeled lymphocytes are often contaminated with platelets, we prepared both 111In-platelets and purified 111In-lymphocytes for use in additional experiments. Allogeneic grafts accumulated platelets and purified lymphocytes independently. Thus, deposition of immunologically active cells in the rejecting graft representing specific pathophysiologic events can be detected. The results suggest that rejection of cardiac transplants can be detected noninvasively, potentially facilitating objective early clinical detection of rejection and titration of antirejection therapy.
Intra-articular pressure and rheumatoid geodes (bone 'cysts').
Authors: M I Jayson, D Rubenstein, A S Dixon
Journal: Annals of the Rheumatic Diseases (1970)

In continental Europe the name 'geode' (which is borrowed from a geological term meaning a rounded pocket of gas in a mineral specimen) is used to describe the radiological appearance of a cyst or cystic erosion in a bone end, so commonly seen in many forms of chronic joint disease.The word is to be preferred as it does not imply (as does 'cyst') that the area is full of fluid-commonly it is not.In the course of rheumatoid arthritis large geodes may develop.Castillo, El Sallab, and Scott (1965) have shown that the size and extent of geode forma- tion in affected hands is related to the type of work in which the patient is engaged.The largest geodes are found in those doing the hardest manual work.Many geodes are small and difficult to puncture.However, two patients with rheumatoid arthritis
Immunosuppression in Patients with High-Grade Gliomas Treated with Radiation and Temozolomide
Authors: Stuart A. Grossman, Xiaobu Ye, Glenn Lesser, Andrew Sloan, Hetty Carraway, Serena Desideri, Steven Piantadosi
Journal: Clinical Cancer Research (2011)

Patients with high-grade gliomas (HGG) routinely receive radiation, temozolomide, and glucocorticoids. As each of these is immunosuppressive, we conducted a prospective, multicenter study to follow CD4 counts over time and determine whether low CD4 counts were associated with adverse outcomes.Patients with newly diagnosed HGG had CD4 counts drawn before initiating standard therapy and monthly thereafter for 1 year. Information on hospitalizations, infections, glucocorticoid use, survival, and cause of death were also collected.Ninety-six evaluable patients were accrued [85% glioblastoma, median age of 57, median Karnofsky performance status (KPS) = 90]. The median CD4 count before radiation and temozolomide treatment was 664 cells/mm(3). The CD4 count nadir occurred 2 months after initiating therapy when 73% of patients had CD4 counts less than 300 cells/mm(3) and 40% had less than 200 cells/mm(3). CD4 counts remained low throughout the year of follow-up. Patients with CD4 counts less than 200 cells/mm(3)at 2 months had shorter survival than those with higher counts (median: 13.1 vs. 19.7 months, P = 0.002). Median survival was related to CD4 toxicity grades (I = 23.8 months, II = 19.7 months, III-IV = 13.1 months, P = 0.009). The adjusted HR for death attributable to 2-month CD4 count below 200 was 1.66 (P = 0.03). Eighty-eight percent of deaths resulted from disease progression, whereas only 2.5% were due to infection.Severe reductions in CD4 counts in patients with newly diagnosed HGG treated with radiation and temozolomide treatment are common, treatment-related, long-lasting, and associated with early death from tumor progression.
A fresh look at augmenter of liver regeneration in rats
Authors: Chandrashekhar R. Gandhi, Ruhul Kuddus, Vladimir M. Subbotin, John Prelich, Noriko Murase, Abdul S. Rao, Michael A. Nalesnik, Simon C. Watkins, Albert DeLeo, Massimo Trucco, Thomas E. Starzl
Journal: Hepatology (1999)

Augmenter of liver regeneration (ALR) is a hepatotrophic protein originally identified by bioassay in regenerating rat and canine livers following partial hepatectomy and in the hyperplastic livers of weanling rats, but not in resting adult livers. The ALR gene and gene product were subsequently described, but little is known about the cellular/subcellular sites of ALR synthesis in the liver, or about the release and dissemination of the peptide. To obtain this information in rats, we raised antibodies in rabbits against rat ALR for development of an enzyme-linked immunosorbent assay (ELISA). ALR concentrations were then determined in intact livers of unaltered weanling and adult rats; in regenerating residual liver after partial hepatectomy; in cultured hepatocytes and nonparenchymal cells (NPCs); and in culture medium and serum. ALR in the various liver cells was localized with immunohistochemistry. In addition, hepatic ALR and ALR mRNA were assayed with Western blotting and reverse-transcriptase polymerase chain reaction (RT-PCR), respectively. The hepatocyte was the predominant liver cell in which ALR was synthesized and stored; the cultured hepatocytes secreted ALR into the medium in a time-dependent fashion. Contrary to previous belief, the ALR peptide and ALR mRNA were present in comparable concentrations in the hepatocytes of both weanling and resting adult livers, as well as in cultured hepatocytes. A further unexpected finding was that hepatic ALR levels decreased for 12 hours after 70% hepatectomy in adult rats and then rose with no corresponding change in mRNA transcripts. In the meantime, circulating (serum) ALR levels increased up to 12 hours and declined thereafter. Thus, ALR appears to be constitutively expressed in hepatocytes in an inactive form, and released from the cells in an active form by unknown means in response to partial hepatectomy and under other circumstances of liver maturation (as in weanling rats) or regeneration.
Silicone oil in the repair of complex retinal detachments
Authors: Stanley P Azen, Ingrid U Scott, Harry W Flynn, Mei-Ying Lai, Trexler M Topping, Lisa Benati, Douglas K Trask, Lee Ann Rogus
Journal: Ophthalmology (1998)

Objective This study aimed to report anatomic and visual acuity outcomes and complications after 1000centistoke silicone oil was used as a retinal tamponade for the treatment of complex retinal detachments. Design Prospective observational multicenter study conducted at community and university-based ophthalmology clinics. Participants The study cohort consisted of 2439 patients (2573 eyes) treated for complex retinal detachments associated with cytomegalovirus (CMV) necrotizing retinitis or a non-CMV etiology, including proliferative diabetic retinopathy, giant retinal tears, proliferative vitreo-retinopathy, or ocular trauma. Intervention Vitrectomy surgery was performed for complex retinal detachment with 1000-centistoke silicone oil as the retinal tamponade. Main outcome measures Anatomic outcomes were complete retinal attachment and macular attachment. Visual acuity outcomes were ambulatory vision (≥4/200) and preservation of preoperative visual acuity. Complications were rates of secondary intraocular pressure elevation (≥30 mmHg), hypotony (≤5 mmHg), corneal opacification (including band keratopathy, corneal edema, and corneal abrasions), oil emulsification, and cataract. Outcomes were assessed 6, 12, and 24 months after surgery. Results At the 6-month examination, the retina was completely attached in 178 (78%) of 228 CMV eyes and in 855 (70%) of 1219 non-CMV eyes. The macula was attached in 216 (95%) of 228 and 1062 (89%) of 1189 CMV and non-CMV eyes, respectively. Ambulatory vision was noted in 151 (65%) of 234 CMV eyes and in 480 (38%) of 1251 non-CMV eyes. Visual acuity was preserved in 106 (46%) of 230 and 1035 (84%) of 1229 CMV and non-CMV eyes, respectively. The corresponding rates of complications for CMV and non-CMV eyes were: elevated intraocular pressure, 0 (0%) of 196 and 35 (3%) of 1196; hypotony, 11 (6%) of 196 and 228 (19%) of 1196; corneal opacity, 13 (6%) of 229 and 326 (26%) of 1248; emulsification, 3 (1%) of 211 and 29 (3%) of 959; and cataract in phakic eyes, 118 (64%) of 185 and 50 (63%) of 80. Conclusions Retinal reattachment was achieved in the majority of eyes using vitrectomy and silicone oil retinal tamponade. Complication rates generally were less frequent in CMV eyes, but follow-up was shorter in this group of patients, largely because of reduced life expectancy. Cataract frequently developed in phakic eyes of study patients. Use of 1000-centistoke silicone oil can be considered in the management of complex retinal detachments associated with multiple etiologies.
Energy Risk Assessment
Authors: Jane M. Orient
Journal: JAMA (1984)

In our affluent technological age, we can afford to base our decisions more on consideration of public health and safety than on brutal economics. In a reversal of the usual cost-benefit equation, Inhaber calculates the cost in lives and disability of generating equivalent amounts of electricity by alternative methods. The comparative risks of conventional fuels (coal, oil, natural gas, and uranium) have been studied by many, including the American Medical Association Council on Scientific Affairs. Inhaber extends the analysis to the "renewable" sources so often invoked by the opponents of nuclear power: wind, water, methanol, ocean thermal gradients, and sun. He attempts to include all phases of production: the acquisition of materials and construction; operation and maintenance; emissions; transportation; energy storage and backup in the case of solar and wind power; and waste disposal and decommissioning in the case of nuclear power. Occupational and public risks are calculated both separately
Temporomandibular dysfunction syndrome associated with scuba diving mouthpieces.
Authors: R S Hobson
Journal: British Journal of Sports Medicine (1991)

As previous reports have highlighted that temporomandibular joint dysfunction syndrome can occur during scuba diving due to the use of a diving mouthpiece, 74 divers of varied experience (62 male, 12 female) were asked to evaluate the efficiency of the mouthpiece for the ease of grip, insertion into the mouth, clearing of water, air sharing, comfort and overall efficiency. They also recorded the level of muscle and joint discomfort experienced during diving and non-diving activities. The results indicate that temporomandibular joint problems unrelated to diving are compounded by the use of a diving mouthpiece. The diver's assessment of muscle tension and comfort while using the mouthpiece was found to be a good predictor of whether temporomandibular dysfunction would occur and the assessment scores have been used in a formula to aid selection of a mouthpiece.
Arthroscopic Surgery for Osteoarthritis of the Knee?
Authors: Robert G. Marx
Journal: New England Journal of Medicine (2008)

Orthopedic surgeons perform arthroscopic surgery in many joints of the extremities, most commonly the knee. Two or three incisions are routinely made, each measuring approximately 7 mm. The knee is inflated with fluid under pressure, with the assistance of a pump, to facilitate visualization. Because of advances in fiberoptics and instrumentation, many knee procedures (e.g., ligament reconstruction, meniscus excision and repair, synovectomy, and removal of loose bodies) can now be performed arthroscopically, with greater ease and accuracy and fewer complications than with an open incision. However, as with any surgical procedure, arthroscopic surgery is not appropriate for all patients with . . .
Pathogenesis of Dissecting Aneurysm
Authors: HERBERT BRAUNSTEIN
Journal: Circulation (1963)

A group of 35 cases of dissecting aneurysm was studied both clinically and pathologically, in order to evaluate the role of alterations in the aortic wall in the pathogenesis of dissecting aneurysm. It was concluded that the commonly observed dilatation and hypertension promoted the initial tear by increasing the tension on the intima of the aorta. The usual cause of the aortic dilatation in this study was severe atherosclerosis; a much smaller group revealed an idiopathic medial degeneration; muscular lesions were regarded either as insignificant or as a result of the dissection. Although in many instances the initial perforation occurred through an atherosclerotic plaque, dissection proceeded readily through histologically normal media. Accordingly, it was concluded that the two histologic lesions encountered produced their effects largely by provoking dilatation of the aorta rather than by promoting propagation of the dissection.
From neural dynamics to true combinatorial structures
Authors: Frank van der Velde, Marc de Kamps
Journal: Behavioral and Brain Sciences (2006)

Various issues concerning the neural blackboard architectures for combinatorial structures are discussed and clarified. They range from issues related to neural dynamics, the structure of the architectures for language and vision, and alternative architectures, to linguistic issues concerning the language architecture. Particular attention is given to the nature of true combinatorial structures and the way in which information can be retrieved from them in a productive and systematic manner.
Impaired sweating as an exocrine manifestation in Sjögren's syndrome
Authors: I. KATAYAMA, H. YOKOZEKI, K. NISHIOKA
Journal: British Journal of Dermatology (2006)

To examine the prevalence of hypohidrosis and to quantitate sweating as an exocrinopathy in Sjögren's syndrome (SS), 49 patients with SS (primary form, 38; secondary form, 11) were studied. Sweating was induced by mental stimulation such as deep breathing or hand grasping. Statistically significant reductions of sweat volume were seen in SS (P < 0.005). Patients under 50 years old showed impaired sweat function compared with normal controls (P < 0.0005). In a control study, only haemodialysis patients showed impairment of sweating and this was greater than in patients with SS aged under 50 years. These results suggest that patients with SS develop impaired sweating as an exocrine manifestation in addition to the known symptoms of xerostomia and xerophthalmus.
901-25 The Paradox of Donor Stimulation of Endothelial-induced Smooth Muscle Growth
Authors: Frank W. Smart, Zhuo Tao, Hector O. Ventura, Mandeep R. Mehra, Dwight D. Stapleton, D. Luke Glancy, Clifford H. Van Meter, Pakarat Vijayagopal
Journal: Journal of the American College of Cardiology (1995)
Dopamine Defect and ADHD
Authors: Rebecca Voelker
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trends in the Prevalence of Extreme Obesity Among US Preschool-Aged Children Living in Low-Income Families, 1998-2010
Authors: Liping Pan, Heidi M. Blanck, Bettylou Sherry, Karen Dalenius, Laurence M. Grummer-Strawn
Journal: JAMA (2012)

ways to reduce the reporting burden on physicians.Currently 4 states (Minnesota, Oregon, Idaho, and North Carolina) allow MOC to count in lieu of continuing medical education for relicensing (and a number of others are moving in that direction), and participation in MOC can result in increased reimbursement through the Physician Quality and Reporting System program.The fees charged for certification and MOC go to support the complex assessment tools, for testing of the information technology platform, and for the rigorous quality standards needed for 19 different subspecialties as well as general medicine.The ABIM works hard to keep fee increases to a minimum and is proud that it charges the second lowest fees of all 24 boards.
133 DYSREGULATION OF FIBROBLAST GROWTH FACTOR NETWORK IN EARLY HEPATOCELLULAR CARCINOMA
Authors: V. Tovar, H. Cornelià, Y. Hoshida, S. Toffanin, A. Villanueva, D. Sia, J. Peix, A. Lachenmayer, C. Alsinet, M. Solé, M. Schwartz, V. Mazzaferro, J. Bruix, J.M. Llovet
Journal: Journal of Hepatology (2011)
Clinical trials: units of randomisation
Authors: P. Sedgwick
Journal: BMJ (2014)

Researchers evaluated the efficacy of a short course of oral prednisolone for acute asthma in children of school age. A randomised double blind placebo controlled crossover trial study design was used. The intervention was parent initiated treatment with the corticosteroid prednisolone (1 mg/kg/day) or placebo when an episode of acute asthma occurred. For each episode, treatment with prednisolone or placebo was chosen at random. Participants were 230 children aged 5-12 years with a history of recurrent episodes of acute asthma. Each child could contribute a maximum of eight episodes of acute asthma to the data collection over a three year study period.1

The primary outcome measure was the mean daytime symptom score over seven days according to a paediatric asthma diary. The daytime symptom score measured the children’s perspectives about their asthma symptoms and how they were limited by their symptoms. The participants contributed a total of 308 episodes of asthma that needed parent initiated treatment: 155 episodes were treated with prednisolone and 153 with placebo. The mean daytime symptom score was 15% lower in episodes treated with prednisolone than in those treated with placebo (P=0.023).

The …
757 3-DAY ADMINISTRATION OF A HIGH FAT DIET INDUCES HEPATIC STEATOSIS AND LIVER ENDOTHELIAL INSULIN RESISTANCE
Authors: M. Pasarín, J.G. Abraldes, A. Rodríguez-Vilarrupla, V. La Mura, J. Gracia-Sancho, J.C. García-Pagán, J. Bosch
Journal: Journal of Hepatology (2009)
JCAHO Tweaks Emergency Departments’ Pneumonia Treatment Standards
Authors: Mike Mitka
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On a Case of Aneurysm of the Abdominal Aorta
Authors: H. F. A. Goodridge
Journal: BMJ (1887)

Wecker, he believed, was the inventor.He had so far seen no disadvantages from the use of irrigation.Mr. GRANGER (Chester) objected to the form of instrument used by Mr. Lee, as being more difficult to keep clean than a simple bottle, the contents of which can so satisfactorily be removed by syphon action.Mr. LEE, in replying, said he was careful to pass an antiseptic solution through the tube before using.In reply to Dr.