Parietal Cell Antibodies
Authors: GRAHAM H. JEFFRIES
Journal: Annals of Internal Medicine (1965)

Editorials1 October 1965Parietal Cell AntibodiesGRAHAM H. JEFFRIES, M.B., M.R.C.P.GRAHAM H. JEFFRIES, M.B., M.R.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-4-717 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIntrinsic factor, secreted by gastric parietal cells in man (1), is necessary for vitamin B12absorption. This substance, a mucoprotein that has yet to be prepared in a pure state, combines with vitamin B12from food and facilitates the transfer of the vitamin across the mucosa of the distal small intestine (2). In patients with pernicious anemia, the mucosal glands in the body and fundus of the stomach are atrophic and contain no parietal cells; neither hydrochloric acid nor intrinsic factor can be detected in stimulated gastric secretions, and vitamin B12absorption is impaired. Hematologic or neurologic manifestations of vitamin...References1. HOEDEMAEKER PJ: Investigations on the Site of Production of Castle's Gastric Intrinsic Factor. Doctoral Thesis, University of Groningen, The Netherlands, 1965. Google Scholar2. HERBERTCASTLE VWB: Intrinsic factor. New Eng. J. Med. 270: 1181, 1964. CrossrefMedlineGoogle Scholar3. FENWICK S: On atrophy of the stomach. Lancet II: 78, 1870. CrossrefGoogle Scholar4. TAYLOR KB: Inhibition of intrinsic factor by pernicious anaemia serum. Lancet II: 106, 1959. CrossrefGoogle Scholar5. SCHWARTZ M: Intrinsic factor antibody in serum from patients with pernicious anemia. Lancet II: 1263, 1960. CrossrefGoogle Scholar6. JEFFRIESHOSKINSSLEISENGER GHDWMH: Antibody to intrinsic factor in serum from patients with pernicious anemia. J. Clin. Invest. 41: 1106, 1962. CrossrefMedlineGoogle Scholar7. TAYLORROITTDONIACHCOUCHMANSHAPLAND KBIMDKGC: Autoimmune phenomena in pernicious anaemia. 1. Gastric antibodies. Brit. Med. J. 2: 1347, 1962. CrossrefMedlineGoogle Scholar8. IRVINE WJ: Gastric antibodies studied by fluorescence microscopy. Quart. J. Exp. Physiol. 48: 427, 1963. CrossrefMedlineGoogle Scholar9. TEVELDEABELSANDERSARENDSHOEDEMAEKERNIEWEG KJGJAPJHO: A family study of pernicious anemia by an immunologic method. J. Lab. Clin. Med. 64: 177, 1964. MedlineGoogle Scholar10. JEFFRIESSLEISENGER GHMH: Immunofluorescent studies in pernicious anemia. J. Clin. Invest. 1965. In press. CrossrefMedlineGoogle Scholar11. JEFFRIES GH: Recovery of gastric mucosal structure and function in pernicious anemia during prednisolone therapy. Gastroenterology 48: 371, 1965. CrossrefMedlineGoogle Scholar12. JEFFRIESSLEISENGER GHMH: Pernicious anemia. Effect of prednisolone on the gastric mucosa. Unpublished observations. Google Scholar13. BERNHARDTBURKETTFIELDSKILLIAN HLLMLJ: The diagnostic significance of the parietal cell immunofluorescent test. Ann. Intern. Med. 63: 635, 1965. LinkGoogle Scholar14. DAGGGOLDBERGANDERSONBECKGRAY JHAJRJSKG: Autoimmunity in iron deficiency anemia. Ann. NY Acad. Sci. 124: 692, 1965. CrossrefMedlineGoogle Scholar15. IRVINEDAVIESTEITELBAUMDELAMOREWYNN WILLIAMS WJSHSIWA: The clinical and pathological significance of gastric parietal cell antibody. Ibid., p. 657. Google Scholar16. ROITTDONIACHSHAPLAND IMDC: Autoimmunity in pernicious anemia and atrophic gastritis. Ibid., p. 644. Google Scholar17. DONIACHROITTTAYLOR DIMKB: Autoimmunity in pernicious anemia and thyroiditis: a family study. Ibid., p. 605. Google Scholar18. HITCHCOCKMACLEANSULLIVAN CRLDWA: The secretory and clinical aspects of achlorhydria and gastric atrophy as precursors of gastric cancer. J. Nat. Cancer Inst. 18: 795, 1957. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 525 E. 68th St., New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLymphocyte Blast-Transformation Test in Vitro in Cases of Chronic GastritisImmune Phenomena in Pernicious AnaemiaImmunological Mechanisms of the Gastrointestinal Tract 1 October 1965Volume 63, Issue 4Page: 717-719KeywordsAntibodiesFoodHydrochloric acidMucous membranesParietal cellsPernicious anemiaSmall intestineStomach Issue Published: 1 October 1965 PDF DownloadLoading ...