Efficacy of Colchicine Prophylaxis in Gout
Authors: TS'AI FAN YÜ
Journal: Annals of Internal Medicine (1961)

Article1 August 1961Efficacy of Colchicine Prophylaxis in GoutPrevention of Recurrent Gouty Arthritis Over a Mean Period of Five Years in 208 Gouty SubjectsTS'AI FAN YÜ, M.D., ALEXANDER B. GUTMAN, M.D., F.A.C.P.TS'AI FAN YÜ, M.D.Search for more papers by this author, ALEXANDER B. GUTMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-2-179 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOver the centuries and into the present era, innumerable regimens have been proposed for prevention of recurrence of acute attacks in the intercritical period of gout. These alleged preventives include an extraordinary assortment of diets, drugs, lotions, and waters, to say nothing of bizarre manipulations (such as acupuncture) apparently derived from ancient ritualistic practices. Each proposal in turn has had its coterie of claimants but none has stood the test of time except, perhaps, for the qualified success of dietary restriction of purines, proteins, and fats.Curiously enough, until comparatively recently there has been only occasional passing reference in the...References1. COHEN A: Gout. Amer. J. Med. Sci. 192: 488, 1936. CrossrefGoogle Scholar2. COHEN A: Gout among arthritics. Penn. Med. J. 41: 1100, 1938. Google Scholar3. TALBOTTCOOMBS JHFS: Metabolic studies on patients with gout. J. A. M. A. 110: 1977, 1938. CrossrefGoogle Scholar4. TALBOTT JH: Gout, Oxford University Press, New York, 1943. Google Scholar5. GUTMAN AB: Some recent advances in the study of uric acid metabolism and gout. Bull. N. Y. Acad. Med. 27: 144, 1951. MedlineGoogle Scholar6. GUTMANYÜ ABTF: Current principles of management in gout. Amer. J. Med. 13: 744, 1952. CrossrefMedlineGoogle Scholar7. TALBOTT JH: Gout, Grune & Stratton, New York, 1957. Google Scholar8. ROBINSON WD: Current status of the treatment of gout. J. A. M. A. 164: 1670, 1957. CrossrefMedlineGoogle Scholar9. RHEUMATISM AND ARTHRITIS: REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS. (Thirteenth Rheumatism Review): Gout and gouty arthritis. Ann. Intern. Med. 53: 119, 1960. Google Scholar10. RHEUMATISM AND ARTHRITIS: REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS. (Twelfth Rheumatism Review): Gout and gouty arthritis. Ann. Intern. Med. 50: 470, 1959. Google Scholar11. GOODMANGILMAN LSA: The Pharmacological Basis of Therapeutics, The Macmillan Company, New York, 1955. Google Scholar12. WALLACE SL: Colchicine. Clinical pharmacology in acute gouty arthritis. Amer. J. Med. 30: 439, 1961. CrossrefMedlineGoogle Scholar13. SHANBROMRAPOPORT EL: Gastrointestinal complications of colchicine therapy in gout. Ann. Intern. Med. 48: 655, 1958. LinkGoogle Scholar14. KUZELLSCHAFFARZICKNAUGLERKOETSMANKLEBROWNCHAMPLIN WCRWWEPEABB: Some observations on 520 gouty patients. J. Chron. Dis. 2: 645, 1955. CrossrefMedlineGoogle Scholar15. SMYTHHUFFMANWILSON CJERGM: Treatment of gout. Arch. Intern. Med. 97: 783, 1956. CrossrefGoogle Scholar16. RUIZ MORENO A: Prevensión de los ataques gotosos por la fenilbutazona. Arch. Argent. Reum. 10: 188, 1956. Google Scholar17. RUIZ MORENO A: Profilaxis de los ataques gotosos por medio de la fenilbutazona. Arch. Argent. Reum. 23: 21, 1960. Google Scholar18. DE SEZERYCKEWAERTLEVERNIEUXMARTEAU SAJR: Physiopathology, clinical manifestations, and treatment of gout. Part 2. Clinical and therapeutic studies. Ann. Rheum. Dis. 17: 15, 1958. CrossrefMedlineGoogle Scholar19. GRAHAM W: The status of phenylbutazone (Butazolidin) in the treatment of rheumatic disorders. Canad. Med. Ass. J. 79: 634, 1958. MedlineGoogle Scholar20. SMYTHFRANKHUFFMAN CJLSER: Urate diuretic therapy in chronic gout. A.I.R. 3: 3, 1960. Google Scholar21. BARTELS EC: Successful treatment of gout. Ann. Intern. Med. 18: 21, 1943. LinkGoogle Scholar22. BARTELSMATOSSIAN ECGS: Gout: six year follow-up on probenecid (Benemid) therapy. Arthritis Rheum. 2: 193, 1959. CrossrefMedlineGoogle Scholar23. TALBOTT JH: The choice of a uricosuric agent in gout. Arthritis Rheum. 2: 182, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: TS'AI FAN YÜ, M.D.; ALEXANDER B. GUTMAN, M.D., F.A.C.P.Affiliations: New York, N. Y.Received for publication April 24, 1961.From the Department of Medicine, The Mount Sinai Hospital, New York, N. Y.This work was supported in part by a grant-in-aid (A-162) from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, U. S. Public Health Service, Department of Health, Education, and Welfare.Requests for reprints should be addressed to Alexander B. Gutman, M.D., Director, Department of Medicine, The Mount Sinai Hospital, Fifth Avenue and One Hundredth Street, New York 29, N. Y. 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SMYTH, M.D., F.A.C.P., ROGER L. BLACK, M.D., CHARLES CHRISTIAN, M.D., MACK L. CLAYTON, M.D., F.A.C.S., DONALD F. HILL, M.D., F.A.C.P., JOSEPH LEE HOLLANDER, M.D., F.A.C.P., WILLIAM M. MIKKELSEN, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CARL M. PEARSON, M.D., F.A.C.P., HUGH A. SMYTHE, M.D., F.R.C.P. (C), L. EMMERSON WARD, M.D., F.A.C.P., HOWARD J. WEINBERGER, M.D., F.A.C.P.A COMPARISON OF URICOSURIC AGENTS IN GOUT, WITH SPECIAL REFERENCE TO SULPHINPYRAZONE 1 August 1961Volume 55, Issue 2 Page: 179-192 Keywords Arthritis Genetics Gout Hospital medicine Medical services Metabolic disorders Prevention, policy, and public health Prophylaxis Proteins Purines ePublished: 1 December 2008 Issue Published: 1 August 1961 Copyright & PermissionsCopyright ©, 1961, by The American College of PhysiciansPDF downloadLoading ...