Blood Pressure Target in Chronic Kidney Disease and Proteinuria as an Effect Modifier
Authors: Robert W. Schrier, Nuttha Lumlertgul
Journal: Annals of Internal Medicine (2011)

Letters2 August 2011Blood Pressure Target in Chronic Kidney Disease and Proteinuria as an Effect ModifierRobert W. Schrier, MD and Nuttha Lumlertgul, MDRobert W. Schrier, MDFrom University of Colorado School of Medicine, Aurora, CO 80045.Search for more papers by this author and Nuttha Lumlertgul, MDFrom University of Colorado School of Medicine, Aurora, CO 80045.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-3-201108020-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The recent review by Uhlig and colleagues (1) concluded that reports from randomized, controlled trials from July 2001 to January 2011 do not provide conclusive evidence that a blood pressure (BP) target less than 130/80 mm Hg improves clinical outcomes more than a target of less than 140/90 mm Hg in patients with stage 3 and stage 4 chronic kidney disease (CKD) As major limitations of their review, the authors cite that no study included patients with diabetes and that trial durations may have been too short (mean follow-up, 2 to 4 years) to detect some clinical ...References1. Upadhyay A, Earley A, Haynes SM, Uhlig K. Systematic review: blood pressure target in chronic kidney disease and proteinuria as an effect modifier. Ann Intern Med. 2011;154:541-8. [PMID: 21403055] LinkGoogle Scholar2. Cushman WC, Evans GW, Byington RP, Goff DC, Grimm RH, Cutler JA, et al; ACCORD Study Group. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med. 2010;362:1575-85. CrossrefMedlineGoogle Scholar3. Thompson AM, Hu T, Eshelbrenner CL, Reynolds K, He J, Bazzano LA. Antihypertensive treatment and secondary prevention of cardiovascular disease events among persons without hypertension: a meta-analysis. JAMA. 2011;305:913-22. [PMID: 21364140] CrossrefMedlineGoogle Scholar4. Schrier RW, Estacio RO, Esler A, Mehler P. Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes. Kidney Int. 2002;61:1086-97. [PMID: 11849464] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Colorado School of Medicine, Aurora, CO 80045.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSystematic Review: Blood Pressure Target in Chronic Kidney Disease and Proteinuria as an Effect Modifier Ashish Upadhyay , Amy Earley , Shana M. Haynes , and Katrin Uhlig Blood Pressure Target in Chronic Kidney Disease and Proteinuria as an Effect Modifier Ashish Upadhyay and Katrin Uhlig Metrics 2 August 2011Volume 155, Issue 3Page: 207-208KeywordsBlood pressureCardiovascular diseasesChronic kidney diseaseClinical trial reportingMicroalbuminuriaMyocardial infarctionProteinuriaStrokeType 2 diabetes ePublished: 2 August 2011 Issue Published: 2 August 2011 CopyrightCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...