tbuckley/cabot-search huggingface dataset:
Characterization of the liver cytosol antigen type 1 reacting with autoantibodies in chronic active hepatitis
Authors: Nisen Abuaf, Catherine Johanet, Pascale Chretien, Eric Martini, Emmanuelle Soulier, Syria Laperche, Jean Claude Homberg
Journal: Hepatology (1992)

An autoantibody to liver cytosol was previously described in childhood autoimmune chronic active hepatitis type 2. The antigen, liver cytosol antigen type 1, was for the first time partially purified using gel filtration and ion exchange chromatography, and it was characterized using immunodiffusion, immunoblot and sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of the immunoprecipitate. Immunoblot detected a unique antigenic peptide at 62 kD from human cytosol and at 58 kD from rat cytosol. The same peptides were also detected when immunoprecipitates of liver cytosol antigen type 1 and autoantibodies to liver cytosol antigen were submitted to sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A polymeric structure, probably a tetramer, is suggested for native liver cytosol antigen type 1 because in gel filtration chromatography liver cytosol antigen type 1 was eluted as a protein of a molecular weight between 240 and 290 kD when human liver cytosol was fractionated and between 220 and 270 kD from rat liver cytosol. Liver cytosol antigen type 1 is probably poor in carbohydrates because it was not stained by periodic acid-Schiff stain. The autoantibodies to liver cytosol were frequently found in association with antiliver kidney microsomal autoantibodies type 1, which are directed against the cytochrome P-450 of the IID6 subfamily. Antiliver kidney microsomal autoantibodies type 1 but not antiliver cytosol autoantibodies were found in association with antibodies to hepatitis C virus. Autoantibodies to liver cytosol antigen type 1 seem to be a more specific marker for autoimmune hepatitis type 2 than antiliver kidney microsomal antibodies type 1 autoantibodies.
British paediatricians help Palestinians with training in child health
Authors: Owen Dyer
Journal: BMJ (2007)

the consultant pathologist whose failure to disclose the results of micro biological tests on one of Sally Clark's two baby sons led to the quashing of her murder convictions, lost his High Court appeal last week against a finding of serious professional misconduct.Mrs Clark was convicted in 1999 of kill ing babies Christopher and Harry but was cleared on appeal in 2003 after spending three and a half years in prison.She died earlier this year at the age of 42.A coroner ruled this week that the cause of her death was acute alcohol intoxication.A General Medical Council fitness to practise panel found Dr Williams, aged 58, guilty of serious professional misconduct in 2005 for not disclosing the results of tests on her second son, Harry, at or before her trial.Dr Williams was banned from doing Home Office forensic pathology or coro ners' work for three years, although he was allowed to continue working as a consult ant histopathologist at Macclesfield General Hospital, in Cheshire.His lawyers appealed on a range of issues, including delays in bringing his case before the GMC.But Mr Justice Davis ruled last week, "In my judg ment this appeal fails on essentially every ground advanced.There was no procedural unfairness giving rise to injustice; nor were the findings and conclusions of the panel wrong."Mrs Clark was cleared after a second appeal, when previously unreported micro biological results came to light.They showed the presence of Staphylococcus aureus at eight sites of the baby's body, including cerebro spinal fluid, raising the possibility that Harry died from natural causes.Dr Williams told the GMC panel that he had not considered the tests to be relevant and that if the defence had wished to see them, they should have asked for them. Court upholds GMC decision over Sally Clark case pathologistUK NEWS Charity warns of proposed restrictions to asylum seekers' access to care, p 1012 World NEWS �erck to pay ���n in rofeco�i� claims, p 1011 �erck to pay ���n in rofeco�i� claims, p 1011 , p 1011 �mj.com �o�ernment may lea�e some patients out of 1�� week tar�et �o�ernment may lea�e some patients out of 1�� week tar�et
Families with disabled children
Authors: Tricia Sloper, Bryony Beresford
Journal: BMJ (2006)

including ergonomic advice and prescription of analgesic drugs if necessary. 7Evidence indicates that such a wait and see policy will suffice for most patients. 1 3-5Most studies were not sufficiently powered to detect clinically relevant subgroup effects, however, so a meta-analysis of individual patient data would help determine which subgroups of patients may benefit from more extensive treatment.Furthermore, a standard set of baseline and outcome measures for patients with lateral epicondylitis will facilitate direct and indirect comparisons of interventions across studies.Clinicians should understand and discuss the advantages and disadvantages of the treatment options with their patients.If people prefer quick relief of symptoms, a corticosteroid injection might be suitable, but the long term prognosis may be poor.For most patients, a wait and see policy with adequate advice and provision of analgesic drugs will suffice.For patients with severe and persistent elbow complaints, physiotherapy may provide an effective, and possibly cost effective, alternative.
Miliary Tuberculosis and Adult Respiratory Distress Syndrome
Authors: JON S. HUSEBY
Journal: Annals of Internal Medicine (1976)

Three patients with miliary tuberculosis developed the adult respiratory distress syndrome. In two patients this complication developed despite treatment with antituberculous drugs. The third patient developed the syndrome, but miliary tuberculosis was not suspected. The presence of disseminated intravascular coagulation in all three cases suggests a possible pathophysiologic relation. Miliary tuberculosis should be considered in patients presenting with adult respiratory distress syndrome of unknown cause.
Reflux in Native Kidneys Mimicking Urine Leak Postrenal Transplant
Authors: Madhavi Tripathi, N Chandrashekar, Rakesh Kumar, Arun Malhotra
Journal: Clinical Nuclear Medicine (2005)

A 19-year man underwent live related renal transplantation for end-stage renal disease. He was referred for a baseline renal scan on day 4. The urine output was satisfactory and the serum creatinine showed a decreasing trend. Renal dynamic scintigraphy with technetium-99m ethylenedicysteine demonstrated radiotracer activity above the transplant kidney, suspected to be a urine leak. Postvoiding posterior, delayed images confirmed that the radiotracer activity in the anterior postvoiding images was the result of vesicoureteral reflux from the patient's native kidneys.
Electron Spin Resonance Studies of Erythrocytes from Patients with Duchenne Muscular Dystrophy
Authors: Bunzo Sato, Koichi Nishikida, Leo T. Samuels, Frank H. Tyler
Journal: Journal of Clinical Investigation (1978)

The membrane organization of the erythrocytes from patients with Duchenne muscular dystrophy was studied by means of electron spin resonance. The fluidity of the membrane near the polar region of Duchenne muscular dystrophy erythrocytes was similar to that of normal erythrocytes. The membrane environment in the nonpolar region, however, was quite different from that of normal erythrocytes, judged by the spectra with 2-(14-carboxytetradecyl) - 2 - ethyl - 4,4 - dimethyl - 3 - oxazolidinyloxyl as probe. The temperature dependence of the ratio of the line height of central field to that at the low field showed two inflection points in normal erythrocytes at pH 7.4 (13.5°-16.5° and 37.5°-40.5°C, respectively) but the inflection point in the lower temperature range was not detected in Duchenne muscular dystrophy erythrocytes. When pH was varied, an abrupt decrease in the ratio was observed at pH 5.9-5.6 in normal erythrocytes whereas there was a gradual decrease over the range of pH from 6.6 to 5.0 in Duchenne muscular dystrophy erythrocytes.
Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells
Authors: Till Seiler, Manuela Woelfle, Sophia Yancopoulos, Rosa Catera, Wentian Li, Katerina Hatzi, Carol Moreno, Marcela Torres, Santanu Paul, Hartmut Dohner, Stephan Stilgenbauer, Matthew S. Kaufman, Jonathan E. Kolitz, Steven L. Allen, Kanti R. Rai, Charles C. Chu, Nicholas Chiorazzi
Journal: Blood (2009)
Outcome and Prognostic Factors in Bronchial Carcinoids: A Single-Center Experience
Authors: Pier Luigi Filosso, Alberto Oliaro, Enrico Ruffini, Giulia Bora, Paraskevas Lyberis, Sofia Asioli, Luisa Delsedime, Alberto Sandri, Francesco Guerrera
Journal: Journal of Thoracic Oncology (2013)
US National Institutes of Health investigates one of its own institutes
Authors: Janice Hopkins Tanne
Journal: BMJ (2007)

Elias Zerhouni, director of the US National Institutes of Health (NIH), has announced “a comprehensive review of the management and leadership” of one of its 27 institutes, the National Institute of Environmental Health Sciences, and the related national toxicology programme.

“Congress and others have raised important questions and concerns over the past few months, and we will be fully responsive,” he said.

The NIH will convene a panel of management consultants and senior NIH officials who are not associated with the environmental institute or the toxicology programme. “The panel will review the specific issues raised to date but also include an evaluation of administrative areas such as governance, internal controls, human resources, contracts, grants, and financial management as well as the administration of the ethics programme,” the NIH said. The review will take several months.

The environmental …
Rheumatic diseases do abound:--a midsummer night's dream
Authors: A. K. Thould
Journal: Annals of the Rheumatic Diseases (1981)

Rheumatic diseases do abound:-a midsummer night's dream At first irritation, then cause for thought, followed by a long look at what I try to do in my daily working life-these were the phases of my reaction to this year's Reith lectures.Though I disagreed with many of Mr Kennedy's points, it seemed to me A. K.
Doxycycline-induced esophagitis
Authors: M. A. Amendola
Journal: JAMA (1985)

<h3>History</h3> A 20-year-old woman presented with a history of several days of dysphagia and burning retrosternal pain radiating to her back. The pain was exacerbated with either solid or liquid ingestion, but was constantly present. She noticed no improvement with changes in position, and was unable to sleep, because of the pain. No history of heartburn, peptic ulcer, fevers, or weight loss was elicited. Review of systems revealed that she had chronic pelvic pain, and had recently completed ten days of doxycycline (Vibramycin) therapy administered in capsules for presumed pelvic inflammatory disease. Her only other medication was an oral contraceptive, which she had taken for two years. Sublingual nitroglycerin had failed to relieve her pain on a previous emergency room visit. Results of the physical examination showed a well-developed, well-nourished woman in no acute distress. Findings from the physical examination were unremarkable. A double-contrast barium swallow was obtained (Fig 1).
Long-term carvedilol treatment in idiopathic dilated cardiomyopathy: biological effects beyond pharmacological activity
Authors: Renata De Maria, Antonello Gavazzi, Gianfranco Sinagra, Oberdan Parodi, Carlo Campana, Danilo Neglia, Mauro Ciaccheri, Marcella Luvini, Luigi Lavecchia
Journal: Journal of the American College of Cardiology (2002)
A tale of two letters
Authors: Andrew Bush, Ian Pavord
Journal: Thorax (2014)

There have been a number of responses. 2 3Richard Smith 2 challenged us to explain why the same ban was not applied to Pharma-funded studies, given the degree of turpitude frequently clinging to that industry.The answer is that, whereas at least some of the actions of big Pharma, for example, in developing new medications, are wholly beneficial, this description can be applied to exactly none of the tobacco industry's doings.So, we consider it reasonable to at least start from a position of giving a new Pharma study the benefit of the doubt and subject it to rigorous peer review.Another response was a self-righteous effusion from the chief scientific officer of BAT, 3 praising the role that the 'regulated tobacco industry' can play.Since this 'well-regulated industry' makes the combined killing machines of all the 20th century dictators seem positively Heath Robinson, we can only respond in the words of Ira Gershwin in Porgy and Bess: 'Friends with you, Low-Life?I fear I must decline!' Were there any doubts as to the rightness of the BMJ's policy, Proctor's intervention 3 would expunge them forthwith.
TCT-454 Incidence and Clinical Impact of Stent Fracture After the Nobori Biolimus-Eluting Stent Implantation
Authors: Shoichi Kuramitsu, Masashi Iwabuchi, Takenori Domei, Kaoru Goya, Kensuke Ohe, Takashi Hiromasa, Yohei Kobayashi, Takashi Morinaga, Makoto Hyodo, Shinichi Shirai, Koyu Sakai, Kenji Ando, Hiroyoshi Yokoi, Masakiyo Nobuyoshi
Journal: Journal of the American College of Cardiology (2013)
Saffron: A potential candidate for a novel anticancer drug against hepatocellular carcinoma
Authors: Amr Amin, Alaaeldin A. Hamza, Khuloud Bajbouj, Salman S. Ashraf, Sayel Daoud
Journal: Hepatology (2011)

Saffron has been proposed as a promising candidate for cancer chemoprevention. The purpose of this investigation was to investigate the chemopreventive action and the possible mechanisms of saffron against diethylnitrosamine (DEN)-induced liver cancer in rats. Administration of saffron at doses of 75, 150, and 300 mg/kg/day was started 2 weeks prior to the DEN injection and was continued for 22 weeks. Saffron significantly reduced the DEN-induced increase in the number and the incidence of hepatic dyschromatic nodules. Saffron also decreased the number and the area of placental glutathione S -transferase–positive foci in livers of DEN-treated rats. Furthermore, saffron counteracted DEN-induced oxidative stress in rats as assessed by restoration of superoxide dismutase, catalase, and glutathione-S-transferase levels and diminishing of myeloperoxidase activity, malondialdehyde and protein carbonyl formation in liver. The results of immunohistochemical staining of rat liver showed that saffron inhibited the DEN-mediated elevations in numbers of cells positive for Ki-67, cyclooxygenase 2, inducible nitric oxide synthase, nuclear factor-kappa B p-65, and phosphorylated tumor necrosis factor receptor. Saffron also blocked the depletion in the number of cells positive for TUNEL (terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labeling) and M30 CytoDeath in liver tissues of DEN-treated rats. In vitro experiments carried out using HepG2 cells also confirmed these findings and showed inhibition of nuclear factor-kappa B activation, increased cleavage of caspase-3, as well as DNA damage and cell cycle arrest upon saffron treatment. Conclusion: This study provides evidence that saffron exerts a significant chemopreventive effect against liver cancer through inhibition of cell proliferation and induction of apoptosis. This report also shows some evidence that saffron protects rat liver from cancer via modulating oxidative damage and suppressing inflammatory response. (HEPATOLOGY 2011;)
Case 6-1968
Authors: Janet W. McArthur, Martin H. Flax
Journal: New England Journal of Medicine (1968)

Presentation of Case First admission. A seventeen-year-old woman was admitted to the hospital because of lethargy.A year previously she had missed three successive menstrual periods. A physician found that she was anemic and prescribed medication of unknown type. Seven months later she began to feel "run down"; there had been a 10-pound weight loss. A slight malar flush and spider angiomas under the nose and right eye were observed. The hemoglobin was 11.6 gm per 100 ml. The white-cell count was 8100, with 39 per cent neutrophils, 44 per cent lymphocytes, 15 per cent eosinophils, 1 per cent monocytes . . .
Asbestos Pleural Effusion?
Authors: FAYSAL M. HASAN
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 November 1975Asbestos Pleural Effusion?FAYSAL M. HASAN, M.D.FAYSAL M. HASAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-5-735_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I read with interest the paper by Galen and associates (1) on hemorrhagic pleural effusion in patients undergoing chronic hemodialysis. When pleural effusion is found in a uremic case, one must rule out other causes. My main interest was in the patient who initially, before the administration of heparin, had a clear yellow pleural fluid, a chest X ray confirming the effusion, and "bilateral pleural thickening with pleural calcification on the right."My inquiry is whether this was a benign persistent pleural effusion associated with asbestosis. Pleural plaques and calcifications from asbestos exposure may occur without parenchymal...References1. GALENSTEINBERGLOWRIE MSE: Hemorrhagic pleural effusion in patients undergoing chronic hemodialysis. Ann Intern Med 82:359-361, 1975 LinkGoogle Scholar2. GAENSLERKAPLAN EA: Asbestos pleural effusion. Ann Intern Med 74:178-191, 1971 LinkGoogle Scholar3. HASANNASHKAZEMI FGH: Epidemiological significance of asbestos-induced and non-asbestos-induced mesothelioma. Unpublished Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine American University Hospital Beirut, Lebanon PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1975Volume 83, Issue 5Page: 735-735KeywordsHeparinPatient advocacyPleural effusionThorax Issue Published: 1 November 1975 PDF downloadLoading ...
Superior Vena Caval Obstruction Noted on Hepatic Flow Study
Authors: BRANDY S. WALKER, THEODORE R. SIMON
Journal: Clinical Nuclear Medicine (1988)

Standard liver/spleen imaging procedures often include dynamic, flow, images of abdominal perfusion. These flow studies may help characterize focal defects found on delayed images. For example, malignant lesions, especially hepatomas, may have rapid flow compared with that of the remainder of the liver. Other lesions, such as cysts, infarctions, and abscesses, will frequently exhibit decreased flow. However, extrahepatic abnormalities, such as the obstructed superior vena cava (SVC) presented here, may also be demonstrated. Additional extrahepatic abnormalities that have been described include pericardial effusions, aortic aneurysms, gastrointestinal bleeding, and others.
Rationing joint replacements: …and is false economy resulting in overall damage
Authors: Martin W McNicol
Journal: BMJ (2005)

Rationing in response to NHS deficits: rural patients are likely to be affected most See News, p 1426Editor-News that pressing financial problems have caused NHS trusts in Suffolk to set new "thresholds" to treatments such as joint replacements reinforces concerns raised by a recent BMA survey of medical directors of trusts in which over a third of respondents anticipated reductions of key services in response to funding shortfalls. 1 2 What has hitherto escaped comment is how cuts in services are far more likely to be felt in some parts of the country than others.Deficits in the NHS are invariably presented as a problem of financial mismanagement, but the pattern of deficits shows that the current resource allocation model discriminates against particular communities.According to the recently published accounts for 2004-5, 3 89 out of 303 (30%) English primary care trusts ended the year in deficit.The table shows how 301 of these trusts are distributed accorded to fifths of deprivation and rurality.Primary care trusts serving populations that are in both the most rural and the least deprived fifth were most likely to be in financial difficulties.Seventeen of the 25 (68%) in this category were in deficit.These trusts received the lowest funding allocation per head (£995).By contrast, only 3% (one of 34) of the primary care trusts serving populations that are in both the most urban and the most deprived fifths failed to break even in 2004-5.These trusts received the highest funding allocations per head (£1405).This shows that poor financial management can at best only partly explain why some trusts are in deficit.The pattern of deficits implies that NHS funding provides insufficient resources for rural areas, for comparatively affluent areas, and, most particularly, for areas that are both rural and affluent.The risk is that such measures will result in NHS services being subject to a new postcode lottery, in which rural residents are more likely to lose out.
Abstract 5129: Identification of therapeutic targets for HPV-positive and HPV-negative head and neck cancers using high throughput RNAi screening
Authors: David O. Azorsa, Irma M. Gonzales, Meredith C. Henderson, Chao Sima, Shilpi Arora
Journal: Cancer Research (2012)

Abstract Cancers of the head and neck account for three percent of all malignancies in the United States and is the sixth most common type of cancer worldwide. Historically, the two most common risk factors for head and neck squamous cell carcinomas (HNSCC) were tobacco use and/or heavy alcohol consumption. Recent growing evidence strongly supports a role for human papillomavirus (HPV) in a subset (15-30%) of HNSCC and there is currently a rise in HPV-related head and neck cancers. In order to improve treatment of head and neck cancers and identify etiology-specific therapeutic targets, we applied a functional genomics based approach utilizing high-throughput RNAi (HT-RNAi) to identify genes specifically involved in growth of either HPV-positive or HPV-negative HNSCC cells. A HT-RNAi assay was developed to quantify the effects of gene specific siRNA on growth inhibition of two HPV-positive (SCC-090 and UMSCC-047) and two HPV-negative (SCC-25 and CAL-27) HNSCC cell lines. For HT-RNAi screening, the four cell lines were reverse-transfected with siRNA from a library targeting 7000 druggable genes with four siRNA per gene and assessed for growth modulation at 96 hours post transfection. The data was normalized using Z-score analysis and statistical cut-offs were set. Following data analysis, we generated a hit list of gene targets that are involved in growth of HPV-positive or HPV-negative HNSCC cells. Validation of these genes will identify potential therapeutic targets for head and neck tumors depending on their HPV status. Furthermore, these findings demonstrate the effectiveness of using HT-RNAi as a tool for the identification of etiologic-specific targets. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5129. doi:1538-7445.AM2012-5129