tbuckley/cabot-search huggingface dataset:
FATAL THYROID CRISIS FOLLOWING INJECTION OF A VARICOSE VEIN
Authors: Earle I. Greene
Journal: JAMA (1931)

One of the most dreaded and serious complications of exophthalmic goiter or primary hyperthyroidism is the acute thyroid crisis. It is a well established fact that acute thyroidism usually occurs in patients in whom the disease has been present and may often be precipitated by apparently minor events. Acute thyroid crises have been known to follow fatigue, inter-current infections and mental or physical stimulation; and fatal cases have been known to occur following an automobile accident, an attack of influenza, an attack of tonsillitis, the opening of a peritonsillar abscess, or an operation for acute appendicitis.  Thyrotoxic patients are poor risks when any form of treatment not aimed at the elimination of the thyrotoxicosis is attempted. It is recognized that even the simplest procedures, unless absolutely necessary, should be postponed until the hyperthyroidism is controlled, for fear of precipitating an acute hyperthyroidism.  This is a report of a fatal case
Inpatient versus Day Clinic Treatment for Bulimia Nervosa: A Randomized Trial
Authors: Almut Zeeck, Stefanie Weber, Angelika Sandholz, Edda Wetzler-Burmeister, Michael Wirsching, Armin Hartmann
Journal: Psychotherapy and Psychosomatics (2009)

&lt;i&gt;Background:&lt;/i&gt; In bulimia nervosa, more intense treatments are recommended if outpatient treatment fails. This is the first randomized controlled trial comparing the options of inpatient versus day clinic treatment. &lt;i&gt;Method:&lt;/i&gt; Patients with severe bulimia nervosa were randomly assigned to inpatient or day clinic treatment of similar length and intensity. Specific and general psychopathology was assessed at the end of treatment and a 3-month follow-up. &lt;i&gt;Results:&lt;/i&gt; Fifty-five patients were randomized; 22 day clinic patients and 21 inpatients started the program. At the end of treatment, a significant reduction of general and specific pathology was found in both settings. Following discharge, there was more deterioration in bulimic symptoms after inpatient treatment, but overall, results were comparable. &lt;i&gt;Conclusions:&lt;/i&gt; Inpatient and day clinic programs are effective treatments for severely disturbed bulimic patients with similar results at the 3-month follow-up. Further follow-up will show if a higher instability of results after inpatient treatment is of importance in the long term.
Plague Meningitis in an American Serviceman
Authors: E. James Feeley
Journal: JAMA (1965)

PLAGUE is an endemic disease in Southeast Asia and when large numbers of US personnel entered the area, measures were taken to protect them from infection. These proved highly effective, but in the case recorded here bubonic plague masqueraded as venereal infection and remained unrecognized until the development of the rare complication of plague meningitis. <h3>Report of a Case</h3> A 23-year-old white male, serving with American military advisors in Viet Nam, was seen in a dispensary on March 21, 1963, with swelling in the left inguinal region, associated with fever, pain, and tenderness. The examining physician noted a questionable penile lesion and made a diagnosis of lymphogranuloma venereum. The patient was treated orally with tetracycline, but the inguinal swelling increased, accompanied by marked edema and erythema. This was interpreted as cellulitis and 2.4 million units daily of procaine penicillin G was given intramuscularly with the tetracycline. On March 23 the
Intraoperative Sentinel Node Mapping with Technitium-99 in Lung Cancer: Results of CALGB 140203 Multicenter Phase II Trial
Authors: Michael J. Liptay, Thomas A. D'amico, Chumy Nwogu, Todd L. Demmy, Xiaofei F. Wang, Lin Gu, Virginia R. Litle, Scott J. Swanson, Leslie J. Kohman
Journal: Journal of Thoracic Oncology (2009)
IMPAIRED CORONARY MICROVASCULAR FUNCTION IS ASSOCIATED WITH FEATURES OF PLAQUE VULNERABILITY
Authors: Saurabh S. Dhawan, Ravi Prasad Avati Nanjundappa, Parham Eshtehardi, Michel Corban, Lucas Golub, Lucas Timmins, Michael McDaniel, Arshed Quyyumi, Habib Samady
Journal: Journal of the American College of Cardiology (2012)
Evidence for an Etiologic Role of Adenoviral Infection in Pertussis Syndrome
Authors: James D. Connor
Journal: New England Journal of Medicine (1970)

Eleven of 13 infants and children with the clinical diagnosis of pertussis syndrome were excreting adenovirus Type 1, 2, 3 or 5 from the respiratory, intestinal or genitourinary tract. Seven of these patients had serologic evidence of recent or current infection. In all patients cultures for Bordetella pertussis or parapertussis were negative, and the majority had no evidence of pertussis infection, as determined by rises in antipertussis agglutinins. These findings add to the evidence of an etiologic association between adenoviral infection and the pertussis syndrome in cases occurring sporadically.
Metabolism of Perfused C <sup>14</sup> -Labeled Nucleosides and Bases by the Isolated Heart
Authors: K. K. TSUBOI, N. M. BUCKLEY
Journal: Circulation Research (1965)

The cardiac metabolism of C 14 -labeled nucleosides and bases was investigated in isolated rabbit hearts perfused with a glucose-electrolyte medium. Records of contractile force, heart rate and coronary drainage were taken at intervals before, during, and after perfusion with a labeled compound. Contractile force was increased in the presence of inosine, uridine, guanosine, and hypoxanthine; and decreased in the presence of adenine. Determination of radioactivity of aliquots of perfusate during C 14 perfusion and washout periods showed generally constant uptake of the labeled compounds by the hearts, after an initial dilution by tissue water, and efficient washout of extracellular label before preparing myocardial extracts. Recirculation of inosine-C 14 was accompanied by incorporation of radioactivity into cardiac nucleotides, chiefly adenine nucleotides but also inosinic acid (IMP) and guanine nucleotides. Labeled hypoxanthine was recovered from both heart and perfusate. Recirculation of uridine-C 14 was accompanied by incorporation of radioactivity into cardiac uridine nucleotides, and the appearance of labeled uracil in the perfusate. In both groups of experiments, the ratio of labeled base to nucleoside in cardiac extracts exceeded the ratio in perfusates, indicating unequal cellular retention of base and nucleoside. Perfusion with guanosine-C 14 led to limited incorporation of C 14 into guanine nucleotides without interconversion to other cardiac nucleotides. Recirculation of C 14 -labeled hypoxanthine or adenine was accompanied by incorporation of radioactivity into cardiac purine nucleotides. Equivalent label distribution was found among adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate, indicating intracellular equilibrium among these compounds. Conversion of labeled adenine to hypoxanthine occurred in the perfusate of the adenine-C 14 experiments. The cardiac metabolism of the perfused nucleosides and bases followed generally predictable sequences, and did not suggest a mechanism for the marked inotropic activity of these compounds.
Errors in a Study of Proportions of Kaposi Sarcoma, Selected Non-Hodgkin Lymphomas, and Cervical Cancer in the United States Occurring in Persons With AIDS, 1980-2007
Authors: Meredith S. Shiels
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Misinterpretation of I-131 Scintigraphy Because of Diaphragmatic Hernia
Authors: SEHER ÜNAL, HARIKA OGUZ, FARUK ALAGÖL, SEMA CANTEZ
Journal: Clinical Nuclear Medicine (1996)

Normally, radioiodine uptake is noted in nasal secretions, the salivary glands, gastric mucosa, and the urinary bladder. In the case of a patient with diaphragmatic hernia, the normal uptake of I-131 in gastric mucosa was interpreted as lung metastasis. In lung uptake of I-131, diaphragmatic hernia should also be considered as a possible misinterpretation of lung invasion.
Triiodo-<scp>l</scp>-thyronine Rapidly Stimulates Alveolar Fluid Clearance in Normal and Hyperoxia-injured Lungs
Authors: Maneesh Bhargava, Marie R. Runyon, Dmitri Smirnov, Jianxun Lei, Thomas J. Groppoli, Cary N. Mariash, O. Douglas Wangensteen, David H. Ingbar
Journal: American Journal of Respiratory and Critical Care Medicine (2008)

Rationale: Edema fluid resorption is critical for gas exchange and requires active epithelial ion transport by Na,K-ATPase and other ion transport proteins.Objectives: In this study, we sought to determine if alveolar fluid clearance (AFC) is stimulated by 3,3′,5 triiodo-l-thyronine (T3).Methods: AFC was measured in in situ ventilated lungs and ex vivo isolated lungs by instilling isosmolar 5% bovine serum albumin solution with fluorescein-labeled albumin tracer and measuring the change in fluorescein isothiocyanate–albumin concentration over time.Measurements and Main Results: Systemic treatment with intraperitoneal injections of T3 for 3 consecutive days increased AFC by 52.7% compared with phosphate-buffered saline-injected control rats. Membranes prepared from alveolar epithelial cells from T3-treated rats had higher Na,K-ATPase hydrolytic activity. T3 (10−6 M), but not reverse T3 (3,3′,5′ triiodo-l-thyronine), applied to the alveolar space increased AFC by 31.8% within 1.5 hours. A 61.5% increase in AFC also occurred by airspace instillation of T3 in ex vivo isolated lungs, suggesting a direct effect of T3 on the alveolar epithelium. Exposure of rats to an oxygen concentration of greater than 95% for 60 hours increased wet-to-dry lung weights and decreased AFC, whereas the expression of thyroid receptor was not markedly changed. Airspace T3 rapidly restored the AFC in rat lungs with hyperoxia-induced lung injury.Conclusions: Airspace T3 rapidly stimulates AFC by direct effects on the alveolar epithelium in rat lungs with and without lung injury.
The Use of Insulin Glargine With Gestational Diabetes Mellitus
Authors: Darby E. Graves, Jenifer C. White, Julienne K. Kirk
Journal: Diabetes Care (2006)

We agree with the recent letter by Woolderink et al. (1) that insulin glargine use during pregnancy may be appropriate. In contrast to that letter, which described the use of insulin glargine in pregnant women with type 1 diabetes, we detail the use of insulin glargine in four patients with gestational diabetes mellitus (GDM). Target blood glucose levels set by the American College of Obstetricians and Gynecologists for women with GDM include fasting glucose ≤95 mg/dl and 1-h postprandial glucose ≤130–140 mg/dl or 2-h postprandial glucose ≤120 mg/dl (2). These criteria are used by the Maternal-Fetal Medicine Clinic at Wake Forest University School of Medicine to determine the need for insulin. …
Desct of a Testis in a Child, Simulating Hernia
Authors: R. P. Bell
Journal: BMJ (1859)

December Gth.She continues to improve.The albumen remnains in the urine.December Oth.She is progressing favourably.The albu- men has dimlini-shed considerably.Was ordered to take five grains of gallio acid in an ounce and a half of water three times a day.
In Situ Bypass Grafting: The Origin and Evolution of an Elegant Technique
Authors: Bruce J. Brener
Journal: JAMA (1987)

How often have you picked up a 150-page monograph on the historical aspects of a surgical operation and been unable to put it down? Or cannot wait to begin reading again? George D. LeMaitre's softcover book<i>In Situ Bypass Grafting</i>is such a work. It is written in an amusing, exciting, peppery style, which must reflect the personality of the author. LeMaitre states frankly that he intends to keep the reader awake and interested. He tries to blend "history, techniques, opinion and controversy." He does this with a sense of humor, modesty, and the pleasant insistence of a master salesman. After all, he is trying to sell an idea, a technique, and an instrument! What makes it even more fun to read is his way of poking at some of our senior academicians, respectfully making his point. He traces the origin of the idea of leaving the saphenous vein in
URINARY CALCULI IN GERMFREE RATS
Authors: Bengt E. Gustafsson, Arne Norman
Journal: The Journal of Experimental Medicine (1962)

In a colony of germfree rats 50 per cent of the males had urinary calculi composed of calcium citrate and calcium oxalate. Genetically closely related conventional animals on the same sterilized diet did not present a single case of stone formation. The tendency to calculus formation disappeared when germfree animals were contaminated with the intestinal flora from conventional rats. The calculus formation can readily be explained by the high calcium, high citrate, and high pH of the urine. This pattern was changed to that of conventional rats when the germfree rats were infected with intestinal microorganisms.
Does the Heterogeneity of Chronic Fatigue Syndrome Moderate the Response to Cognitive Behaviour Therapy? An Exploratory Study
Authors: Matteo Cella, Trudie Chalder, Peter D. White
Journal: Psychotherapy and Psychosomatics (2011)

&lt;i&gt;Background:&lt;/i&gt; Chronic fatigue syndrome (CFS) is a heterogeneous condition. A few studies have shown that some independent factors predict outcomes after cognitive behaviour therapy (CBT). Two recent systematic reviews suggest that heterogeneity may moderate treatment outcomes. However, no study has explored whether subgroups of CFS predict response to treatment. &lt;i&gt;Methods:&lt;/i&gt; We used both latent class analysis (LCA) and latent class regression (LCR) to clarify the relationship between subgroups of CFS patients (n = 236), diagnosed using the Oxford diagnostic criteria, and the response to CBT. We measured symptoms, demographics, mood, and cognitive and behavioural responses to illness to define subgroups. &lt;i&gt;Results:&lt;/i&gt; We found 5 latent classes by LCA, which did not differ in the direction of their response to CBT, with all classes showing improvement. In contrast, an exploratory LCR identified 4 latent classes, 1 of which predicted a poor response to CBT, whereas the other 3 predicted a good outcome, accounting for more than 70% of the patients. The negative outcome class was defined by weight fluctuations and physical shakiness, anxiety, pain and being focused on symptoms. &lt;i&gt;Conclusions:&lt;/i&gt; CBT should be offered to all classes of patients with CFS, when defined by these measures. It may be possible to predict a minority group with a negative outcome, but this exploratory work needs replication.
THE INFLUENCE OF INSULIN UPON ACIDOSIS AND LIPAEMIA IN DIABETES: (A Preliminary Communication.)
Authors: H. W. Davies, C. G. Lambie, D. M. Lyon, J. Meakins, W. Robson
Journal: BMJ (1923)

TM ( B' 847in heterophoria a tendency for the visual axes to depart from parallelism, and the necessary co-ordination is effected by excessive use of the fusion faculty.When the muscles are fatigued this state of suppressed squint may become actual strabismus, and diplopia may he complained of.It is obvious that heterophoria disturbs the co-ordina- tion between accommodation and convergence, and that increased nervous energy is used up in each act of combined vision.In consequence fatigue will develop and cause asthenopia and headache.It is therefore essential that the error shall be corrected.I shall not here go into the details of the examination.We use the Maddox rod and tangent scale for testing the muscle balance at infinity,and the Maddox wing test for measuring the error at reading distance.HyperphGria causes most trouble, but is not common.The most frequent defect is weakness of converging power, and this causes difficulty in reading and needlework.It is cor- rected by adding prisms base in to the near glasses, and such an addition is greatly appreciated by those who have convergence insufficiency.
Passive Smoke Inhalation Decreases Exhaled Nitric Oxide in Normal Subjects
Authors: DEBORAH H. YATES, HELEN BREEN, PAUL S. THOMAS
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Environmental tobacco smoke (ETS) exposure is one of the commonest pollutants in modern society. Despite documented clinical adverse effects of ETS on the lungs, objective methods of assessing airway damage have been lacking. Exhaled nitric oxide (eNO) is a rapid, sensitive method of assessing airway inflammation, and could be useful in this regard. Active smoking decreases eNO in normal subjects and eNO levels are low in habitual smokers, but the effect of ETS exposure on eNO has not previously been examined. In a single-blinded, placebo-controlled cross-over study, we examined the effect of ETS, sham and active smoke inhalation on eNO in non-smoking normal volunteers. Subjects were exposed to smoke over a period of 1 hour in a separately ventilated chamber, and eNO was measured at baseline, 15, 30, 45 and 60 minutes. With sham inhalation (n = 15), eNO levels did not change significantly from baseline, although a small decrease occurred. ETS exposure (n = 15) resulted in a rapid fall in eNO from mean (SE) 134 (29) ppb to 102 (22) ppb, or by 23.6% (p < 0.05), and remained low for 60 minutes. With active smoking (n = 7), levels fell acutely from baseline within the same time interval (71 [16] to 49 [11] ppb, or by 30.3%), and remained low. These changes were significant compared with sham exposure for both ETS (p < 0.05) and active smoke inhalation (p < .01). This suggests that eNO can be used for the investigation of the mechanisms of cigarette-induced lung damage in the experimental setting, and may potentially be useful also for environmental assessment of ETS effects.Keywords: nitric oxide; environmental tobacco smoke; airway inflammation
A Plea for Biobanking of All Equivocal Melanocytic Proliferations
Authors: H. Peter Soyer, Lynlee L. Lin, Tarl W. Prow
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Kilroy and Oedipus
Authors: Robert J. Needles
Journal: JAMA (1963)

<h3>To the Editor:</h3> —Dr. Thaddeus Kostrubala has carried out an exquisite piece of work in his analysis of rolling stones and moss (<i>JAMA</i><b>185</b>, Sept 21, 1963, adv p 211). Most of us, unable to adopt so scientific an attitude, prefer that system suggested in a recent book on the psychoanalytic method. Its author believes that the phonetic significance of words and phrases is of transcendental importance. An example is "Kilroy," as in "Kilroy was here." It can be seen, quite easily, that Kilroy, pronounced by syllables, refers to the assassin of the king, the Oedipus, and what a monumental mess that makes of the GI unconscious.
Do trainees see patients with chronic illness?
Authors: J Chasler
Journal: BMJ (1983)

From 1976 to 1979 trainees in the Oxford region had their clinical work monitored while in their training practices in relation to 16 conditions requiring long term supervision. Although the mean numbers of patients seen were not greatly different from national figures, the range identified some trainees whose number of patients was very low. Consultation rates and follow up figures indicated that many patients did not return to the trainees again.
X Inactive–Specific Transcript RNA Coating and Genetic Instability of the X Chromosome in <i>BRCA1</i> Breast Tumors
Authors: Anne Vincent-Salomon, Carine Ganem-Elbaz, Elodie Manié, Virginie Raynal, Xavier Sastre-Garau, Dominique Stoppa-Lyonnet, Marc-Henri Stern, Edith Heard
Journal: Cancer Research (2007)

Abstract Identification among breast tumors of those arising in a hereditary BRCA1 context remains a medical challenge. Abnormalities in X chromosome copy number and in the epigenetic stability of the inactive X chromosome (Xi) have been proposed to characterize BRCA1 breast tumors. In particular, it has been proposed that loss of BRCA1 function can lead to loss of X inactive–specific transcript (XIST) RNA association with the Xi. However, few studies have addressed this issue in a sufficiently large series of BRCA1 primary tumors. Here we assess X-chromosome status using single-cell (RNA and DNA fluorescence in situ hybridization) and global genomic (array-comparative genomic hybridization and allelotyping) approaches on a series of 11 well-defined BRCA1 tumors. We show that many or most cells of the tumors contain one or more XIST RNA domains. Furthermore, the number of XIST RNA domains per cell varied considerably even within a single tumor. Frequent X-chromosome allelic and copy number aberrations were found, in agreement with aberrant XIST RNA domain numbers. In summary, by combining multiple approaches to assess the genetics and epigenetics of a large series of BRCA1 primary tumors, we can conclude definitively that BRCA1 is not required for XIST RNA coating of the X chromosome. The intratumoral and intertumoral variability in XIST RNA domain number in BRCA1 tumors correlates with chromosomal genetic abnormalities, including gains, losses, reduplications, and rearrangements of the X-chromosome. Finally, we also show the necessity for combined global and single-cell approaches in the assessment of tumors with such a high degree of heterogeneity. [Cancer Res 2007;67(11):5134–40]