tbuckley/cabot-search huggingface dataset:
Changes in a Population of Hospitalized Patients with Affective Disorders, 1945-1965
Authors: SAUL H. ROSENTHAL
Journal: American Journal of Psychiatry (1966)

Changes in the patient population at the Massachusetts Mental Health Center over a 20-year period were documented by examining the discharge records of the first six months for the years 1945, 1955, and 1965. Among those patients diagnosed as having affective disorders, there was a marked shift in the age distribution toward a younger population, predominantly female, with a marked increase in the proportion of depressive reactions and a decrease in manic-depressive and involutional psychotic diagnoses. The author suggests that these population changes may parallel the redefinition of mental illness and the greater acceptance of psychiatric hospitalization during the last 20 years.
The yield of endoscopic ultrasound-guided fine needle aspiration for histological diagnosis in patients suspected of stage I sarcoidosis
Authors: T. Iwashita, I. Yasuda, S. Doi, T. Kato, K. Sano, S. Yasuda, M. Nakashima, Y. Hirose, T. Takami, H. Moriwaki
Journal: Endoscopy (2008)

See also: Commentaire de travail de T. Iwashita et al., pp. 400Endoscopy 2008; 40(05): 454-455DOI: 10.1055/s-0032-1306832
Syndrome of Inappropriate Secretion of Antidiuretic Hormone with Exacerbated Psychosis
Authors: STEVEN L. DUBOVSKY
Journal: Annals of Internal Medicine (1973)

The syndrome of inappropriate secretion of antidiuretic hormone (ADH) occurred during an acute psychotic reaction in a patient who was taking no medications and had no evidence of volume depletion or of renal, hepatic, cardiac, or endocrine disease. The syndrome resolved with improvement of the acute psychotic state; it recurred during a second psychotic episode and again resolved with remission of the acute psychosis. It is therefore concluded that the acute psychotic episode, or some consequence thereof, caused the syndrome in this patient. The possible pathway(s) for this inappropriate secretion of vasopressin associated with this acute psychosis, and its implications, are discussed.
Case 17-1961
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. Kibbee
Journal: New England Journal of Medicine (1961)

Presentation of Case A thirteen-year-old girl was admitted to the hospital because of enlargement of the left breast. Progressive enlargement of the left breast occurred during the nine months before entry. There was no history of trauma, bleeding or discharge from the nipple. X-ray films of the chest one month before admission were normal. The menses had begun eleven months before admission. Physical examination showed a well nourished girl in no distress. The left breast was enlarged, with cutaneous striae, venous engorgement and a firm, movable mass, 12 by 12 cm. No axillary lymph nodes were palpable. The right breast . . .
Erythrocyte membrane proteins in hereditary glucosephosphate isomerase deficiency.
Authors: T Coetzer, S S Zail
Journal: Journal of Clinical Investigation (1979)

Erythrocytes (approximately equal to 50% reticulocytes) obtained from a splenectomized patient with a thermolabile variant of glucosephosphate isomerase (GPI) deficiency showed a striking degree of crenation and decreased filterability through 3-micrometer Nuclepore filters (Nuclepore Corp., Pleasanton, Calif.). Membranes prepared by hypotonic lysis of such erythrocytes were found to contain a high molecular weight aggregate which was probably disulphide-bonded. The 10% most dense erythrocyte fraction showed an accentuation of aggregate formation while aggregates could not be detected in the 10% least dense erythrocyte fraction. The aggregate consisted mainly of spectrin (band 1) and a protein with the mobility of 4.2. "Extractability" of spectrin from these membranes was also markedly diminished. Incubation of the erythrocytes for 24 h in substrate-free medium caused more pronounced spectrin aggregation than in low or high reticulocyte controls. Incubation of low or high reticulocyte controls for 24 h in medium that contained glucose completely prevented the formation of the high molecular weight aggregate. GPI-deficient erythrocytes incubated with glucose in the medium showed an accentuation of membrane protein aggregate formation; however, this was almost completely reversed by the addition of adenine and inosine to the incubation medium or by the use of fructose, the intermediate just distal to the "block" in glycolysis, as the sole substrate. ATP and reduced glutathione levels in the GPI-deficient erythrocytes incubated with glucose were similar to that found in the low and high reticulocyte controls. Our findings suggest that only a proportion of erythrocytes (the older, more dense population of cells) are susceptible to the formation of disulphide-bonded aggregates, and that this is directly related to an impairment of substrate flow through the glycolytic sequence. The exact mechanism of aggregate formation in these erythrocytes remains to be elucidated.
Biomarkers and Molecular Subtypes in Primary Breast Tumors and Metastases: Associations with Liver Metastases and Outcome
Authors: S. Kimbung, A. Kovács, I. Johansson, A. Danielsson, P. Bendahl, Z. Einbeigi, M. Ferno, T. Hatschek, I. Hedenfalk
Journal: Annals of Oncology (2014)
SOME OBSERVATIONS ON NEURODEUMATITIS OF THE SOALP. WITH PARTICULAR REFERENCE TO TINEA AMUNTACEA*
Authors: W. HERBERT BROWN
Journal: British Journal of Dermatology (1948)

Journal Article SOME OBSERVATIONS ON NEURODEUMATITIS OF THE SOALP. WITH PARTICULAR REFERENCE TO TINEA AMUNTACEA Get access W. HERBERT BROWN, M.D.GIasgow W. HERBERT BROWN, M.D.GIasgow Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 60, Issue 3, 1 March 1948, Pages 81–90, https://doi.org/10.1111/j.1365-2133.1948.tb10998.x Published: 01 March 1948
Neural constructivism: How mammals make modules
Authors: Robert A. Barton
Journal: Behavioral and Brain Sciences (1997)

Although the developmental arguments in the Quartz &amp; Sejnowski (Q&amp;S) target article may have intrinsic merit, they do not warrant the authors' conclusion that innate modular architectures are absent or minimal, and that neocortical evolution is simply a progression toward more flexible representational structures. Modular architectures can develop and evolve in tandem with sub-cortical specialisation. I present comparative evidence for the co-evolution of specific thalamic and cortical visual pathways.
Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy
Authors: Stefan Blüml, Ashley S. Margol, Richard Sposto, Rebekah J. Kennedy, Nathan J. Robison, Marzieh Vali, Long T. Hung, Sakunthala Muthugounder, Jonathan L. Finlay, Anat Erdreich-Epstein, Floyd H. Gilles, Alexander R. Judkins, Mark D. Krieger, Girish Dhall, Marvin D. Nelson, Shahab Asgharzadeh
Journal: Neuro-Oncology (2015)

Medulloblastomas in children can be categorized into 4 molecular subgroups with differing clinical characteristics, such that subgroup determination aids in prognostication and risk-adaptive treatment strategies. Magnetic resonance spectroscopy (MRS) is a widely available, noninvasive tool that is used to determine the metabolic characteristics of tumors and provide diagnostic information without the need for tumor tissue. In this study, we investigated the hypothesis that metabolite concentrations measured by MRS would differ between molecular subgroups of medulloblastoma and allow accurate subgroup determination. MRS was used to measure metabolites in medulloblastomas across molecular subgroups (SHH = 12, Groups 3/4 = 17, WNT = 1). Levels of 14 metabolites were analyzed to determine those that were the most discriminant for medulloblastoma subgroups in order to construct a multivariable classifier for distinguishing between combined Group 3/4 and SHH tumors. Medulloblastomas across molecular subgroups revealed distinct spectral features. Group 3 and Group 4 tumors demonstrated metabolic profiles with readily detectable taurine, lower levels of lipids, and high levels of creatine. SHH tumors showed prominent choline and lipid with low levels of creatine and little or no evidence of taurine. A 5-metabolite subgroup classifier inclusive of creatine, myo-inositol, taurine, aspartate, and lipid 13a was developed that could discriminate between Group 3/4 and SHH medulloblastomas with excellent accuracy (cross-validated area under the curve [AUC] = 0.88). The data show that medulloblastomas of Group 3/4 differ metabolically as measured using MRS when compared with SHH molecular subgroups. MRS is a useful and accurate tool to determine medulloblastoma molecular subgroups.
Circulating Immune Complexes: Their Immunochemistry, Detection, and Importance
Authors: EUGENE V. BARNETT
Journal: Annals of Internal Medicine (1979)

The size and molecular composition of circulating immune complexes depend on various factors, including the concentrations and valences of antigens and antibodies and the antigen-antibody ratio. The composition and biological properties of circulating immune complexes, in turn, influence their fate in vivo as well as the likelihood of their detection by various assays. Several assays clearly detect circulating immune complexes, but no single assay has yet been shown to be the most sensitive and the most specific for the entire spectrum of circulating immune complexes. Assays correlate poorly with each other, but this may be desirable if we are to determine which circulating immune complexes have diagnostic, prognostic, or pathogenic importance. Circulating immune complexes are found in numerous rheumatologic disorders and infectious diseases. Their presence in the circulation statistically correlates with disease activity; however, the assays currently used have limited value for diagnosing or aiding in therapeutic decisions. Nevertheless, the future holds promise for such uses.
The Reverend Joseph Priestly
Authors: Ronald Fishman
Journal: JAMA (1962)

<h3>To the Editor:—</h3> In the Aug. 4 issue ofThe Journal(<b>181</b>:437) 1962, there is an editorial concerning the Reverend Joseph Priestly who "spoke from the pulpit as a heterodox minister." More explicitly, Reverend Priestly was a Unitarian minister who established in Philadelphia in 1796 the first Unitarian Church in the United States. I may add that this is the same heterodox theology which nurtured Thomas Jefferson, John Adams, John Quincy Adams, and Florence Nightingale, and which continues to nurture such people as Dr. Albert Schweitzer.
Reliability of the maximum derivatives of left ventricular pressure and internal diameter as indices of the inotropic state of the depressed myocardium
Authors: G. E. BARNES, L. D. HORWITZ, V. S. BISHOP
Journal: Cardiovascular Research (1979)

The effects of inotropic stimulation and increases in end-diastolic diameter, aortic pressure, left ventricular end diameter size, mean arterial pressure, and heart rate on maximum rate of change of left ventricular pressure (dP/dtmax) and diameter (dD/dtmax) were studied in eight dogs. Responses were studied in the normal conscious state, during myocardial depression due to high doses of pentobarbital or propranolol, and after bilateral cardiac sympathectomy. In all states studied, both dP/dtmax and dD/dtmax were substantially augmented by inotropic stimulation with isoprenaline and were less influenced by changes in end-diastolic diameter, mean arterial pressure and heart rate. It is concluded that both indices are highly sensitive to the contractile state of the left ventricle and relatively insensitive to haemodynamic alterations in both normal and depressed hearts.
CONSTRICTION OF THE BRACHIAL ARTERY DURING BRACHIAL ARTERY REACTIVITY TESTING PREDICTS MAJOR ADVERSE CLINICAL OUTCOMES IN WOMEN WITH SUSPECTED MYOCARDIAL ISCHEMIA: THE NHLBI-SPONSORED WOMEN’S ISCHEMIA SYNDROME EVALUATION (WISE) STUDY
Authors: B. Delia Johnson, Steven E. Reis, Sheryl F. Kelsey, Carl J. Pepine, Vera Bittner, William J. Rogers, Eileen Handberg, Wafia Eteiba, George Sopko, Barry L. Sharaf, C. Noel Bairey Merz
Journal: Journal of the American College of Cardiology (2010)
Psychoendocrinology of Remenorrhea in the Late Outcome of Anorexia nervosa
Authors: Adolf-Ernst Meyer, Beate von Holtzapfel, Gerhard Deffner, Klaus Engel, Maggy Klick
Journal: Psychotherapy and Psychosomatics (1986)

Within a late follow-up of our former anorectic patients 38 consented to an endocrine checkup in addition to clinical and sociopsychologic assessments. Univariate comparisons of still or again amenorrheic patients (n = 22) versus remenorrheic patients (n = 16) showed many significances. However, some of these variables intercorrelated substantially. Therefore, we performed a stepwise discriminant analysis which yielded as the most differentiating variables 'subjective well-being' (24%), follow-up interval (16%), Frisch's 'fat percentage within body weight' (12%) and 'sexual behavior' (5%). As the mean follow-up intervals were 10 versus 6 years, anorectic patients seem to need considerable time for remenorrhea, or rather for the psychosocial-sexual adaptation necessary for it. The equally necessary weight gain does not correlate with the follow-up interval. Then there is a factor which seems to be 'constitutional': Early onset of amenorrhea predicts late nonremenorrhea (3%).
Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation
Authors: Marc Beyer, Yasser Thabet, Roman-Ulrich Müller, Timothy Sadlon, Sabine Classen, Katharina Lahl, Samik Basu, Xuyu Zhou, Samantha L Bailey-Bucktrout, Wolfgang Krebs, Eva A Schönfeld, Jan Böttcher, Tatiana Golovina, Christian T Mayer, Andrea Hofmann, Daniel Sommer, Svenja Debey-Pascher, Elmar Endl, Andreas Limmer, Keli L Hippen, Bruce R Blazar, Robert Balderas, Thomas Quast, Andreas Waha, Günter Mayer, Michael Famulok, Percy A Knolle, Claudia Wickenhauser, Waldemar Kolanus, Bernhard Schermer, Jeffrey A Bluestone, Simon C Barry, Tim Sparwasser, James L Riley, Joachim L Schultze
Journal: Nature Immunology (2011)
Cannabis--accidental peroral intoxication. The hashish smuggler roentogenographically unmasked
Authors: H. H. Lopez
Journal: JAMA (1974)

A patient ingested contraband hashish in rubber balloons, as demonstrated on abdominal roentgenograms. One balloon ruptured, and intoxication resulted. This patient developed an unusual and previously unreported sign of transient pupillary asymmetry. Initial and subsequent x-ray films were used to follow the passage of the foreign bodies.
Longer-Term Follow-Up of Patients Recruited to the REACT (Rescue Angioplasty Versus Conservative Treatment or Repeat Thrombolysis) Trial
Authors: Amanda Carver, Suzanne Rafelt, Anthony H. Gershlick, Kathryn L. Fairbrother, Sarah Hughes, Robert Wilcox
Journal: Journal of the American College of Cardiology (2009)

To evaluate the longer-term outcomes for rescue percutaneous coronary intervention (R-PCI). Thrombolysis remains an important, commonly used reperfusion therapy, yet failure to achieve complete reperfusion occurs relatively frequently. A number of recent trials have focused on the management of patients with thrombolytic failure, including the REACT (Rescue Angioplasty Versus Conservative Treatment or Repeat Thrombolysis) trial, which demonstrated a significant 6-month benefit favoring R-PCI. However, longer-term maintenance of benefit for R-PCI has not been demonstrated. Rates of the primary composite end point (major adverse cardiac and cerebrovascular events) to 1 year and mortality to a median of 4.4 years in 427 patients included in the 3 randomized arms of the REACT trial (repeat lysis, conservative therapy, and R-PCI) were analyzed. One-year event-free survival for patients randomized to R-PCI was 81.5%, compared with 64.1% for repeat thrombolysis and 67.5% for conservative therapy (overall p = 0.004). Adjusted hazard ratio was 0.44 (95% confidence interval [CI]: 0.28 to 0.71; p = 0.0008) for R-PCI versus repeat thrombolysis and 0.51 (95% CI: 0.32 to 0.83; p = 0.007) for R-PCI versus conservative therapy. Adjusted hazard ratio for longer-term (median 4.4 years) overall mortality for R-PCI versus repeat thrombolysis was 0.41 (95% CI: 0.22 to 0.75; p = 0.004) and 0.43 (95% CI: 0.23 to 0.79; p = 0.006) for R-PCI versus conservative therapy. There was no difference in either analysis between repeat thrombolysis and conservative strategies. Rescue PCI, previously shown to be superior in the short term to both repeat thrombolysis and conservative therapy, maintains benefit in terms of long-term mortality. This strategy for failed lysis should be mandated as part of thrombolytic-based ST-segment elevation myocardial infarction protocols.
IS PLAQUE RUPTURE CAVITY SIZE RELATED TO PLAQUE COMPOSITION? A LAYERED ANALYSIS WITH INTRAVASCULAR ULTRASOUND VIRTUAL HISTOLOGY RADIOFREQUENCY DATA
Authors: Ling Zhang, Tomas Kovarnik, Taishi Hirai, Zhi Chen, Katie Porcaro, John Kaminski, Stephen Hawn, Anoop Agrawal, Richard Downe, Andreas Wahle, Milan Sonka, John Lopez
Journal: Journal of the American College of Cardiology (2014)
A darkly pigmented lesion with recent changes
Authors: U. Sarwar, W. A. Townley, M. Nicolaou, M. S. Khan
Journal: BMJ (2011)

A 65 year old retired construction worker was urgently referred by his general practitioner to the dermatology clinic. He had noticed that a darkly pigmented painless lesion on his back, which had been present for two years, had recently begun to increase in size and weep blood. He had never had any similar lesions before and he was otherwise healthy.

On examination, he was noted to have a 2 cm irregular lesion on his back with dark pigmentation (figure⇓). There was no lymphadenopathy and further skin examination was normal. All other systems examinations were unremarkable.



Pigmented skin lesion





### 1 How should a clinician assess a patient presenting with a pigmented skin lesion?

#### Short answer

Take a thorough history. Ask about the natural course of the lesion including change in size, shape, oozing, bleeding, pain, and change in sensation. Risk factors for melanoma should also be elicited by asking about exposure to ultraviolet radiation, family or personal history of melanoma, and immunosuppression. Perform a head to toe examination of the skin and other systems.

#### Long answer

The natural history of a lesion can give vital clues to the likely diagnosis. Any pigmented mole that has been subject to recent change should alert suspicion. The seven point checklist (box 1) provides a more formal assessment tool to determine the likelihood of a suspicious lesion being melanoma and should form the basis of the history.1 The checklist emphasises the importance of any change in size, shape, and colour of a pre-existing pigmented lesion (major features). Symptoms such as bleeding, itching, and …
Jaundice Associated With Metronidazole
Authors: I. Donald Fagin
Journal: JAMA (1965)

To the Editor:—  Metronidazole was introduced in the treatment of trichomoniasis in 1959-1960.1To date there has been no report of hepatic toxicity attributable to this drug, but adverse drug reactions parallel increased use and this communication reports a patient who developed jaundice, apparently as a manifestation of liver injury, following metronidazole ingestion.  From Dec 1, 1964, to Dec 5, a previously healthy 46-year-old white salesman took one 250-mg tablet of metronidazole daily at the suggestion of his paramour, who was taking the drug for genital trichomoniasis. On Dec 5 he developed malaise, chills and fever (101 F [39.3 C] ). Two days later a physician administered penicillin parenterally, with analgesics. Low grade fever (100 F [37.8 c]) persisted, and jaundice, dark urine, and light stools were noted on Dec 10. On Dec 14, examination revealed conjunctival and mild cutaneous icterus and a slightly tender liver enlarged to 4 cm
Not an HIV Cure, but Encouraging New Directions
Authors: Jay A. Levy
Journal: New England Journal of Medicine (2009)

The history of infectious diseases frequently includes people who were resistant to a pathogen. Such a phenomenon helped the Spanish, who had resistance to smallpox, in their conquest of South America, but not the Aztecs or the Incas, who had no resistance to smallpox and were decimated by the virus.1 Microbial resistance involves adaptive (acquired) immunity (e.g., the HLA subtype) or innate (natural) immunity resulting from the genetic makeup of the host.2 With the human immunodeficiency virus (HIV) and its known destruction of the immune system, resistance to infection and disease was not initially expected. However, certain people — long-term . . .
Women’s Sexual Function and Dysfunction: Study, Diagnosis, and Treatment
Authors: Rosemary Basson
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thoracocervical cysts as a cause of stridor
Authors: B. T. le Roux, B. J. Henderson, E. U. Kurklu, M. A. Rogers
Journal: Thorax (1974)

<b>le Roux, B. T., Henderson, B. J., Kürklü, E. U., and Rogers, M. A. (1974).</b><i>Thorax</i>, <b>29</b>, 564-566. <b>Thoracocervical cysts as a cause of stridor.</b> In five patients with severe stridor four were shown to have as the cause a duplication of foregut and the fifth a cystic hygroma. All were managed surgically and are well. In one patient tracheal obstruction was so severe that asphyxia and an episode of cardiac arrest preceded surgical management. Foregut duplication, particularly in children, is an important and remediable cause of respiratory obstruction.
Infection with penicillinase-producing gonococcus.
Authors: A E Wilkinson, A D Seth, P Rodin
Journal: BMJ (1976)

in ten, and one in three, respectively.In October 792 prescription forms were studied (1201 prescription items), in January 255 (413), and in March 616 (979).In the three individual months 1663 prescriptions were examined (2593 prescription items): 344 (13 2 ',.) of these items were for tranquillisers such as diazepam or tricyclic compounds such as imipramine, while 50 (2 ,O) were for barbiturates either of the short-acting type or as contained in some antacid mixtures or so-called migraine remedies.The actual numbers of barbiturate prescription items in the tested sample were 20 in October, 5 in January, and 25 in March.Examination of the table shows that patients receiving anxiolytic treatment, antidepressive treatment, and sedative measures had their prescription items written more often than not by the receptionist.Percentage of prescriptions zritten by receptionist