Prophylactic Anticoagulant Therapy in the Orthopedic Patient
Authors: LEO T. NEU
Journal: Annals of Internal Medicine (1965)

Article1 March 1965Prophylactic Anticoagulant Therapy in the Orthopedic PatientLEO T. NEU JR., M.D., F.A.C.P., JIM R. WATERFIELD, M.D., CHARLES J. ASH, M.D.LEO T. NEU JR., M.D., F.A.C.P.Search for more papers by this author, JIM R. WATERFIELD, M.D.Search for more papers by this author, CHARLES J. ASH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-3-463 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is well-established that patients subjected to immobilization are prone to thrombo-embolic phenomena. Postoperative debilitation provides adequate stasis for this complication. In a series of 5,000 postoperative cases studied by Milch, Berman, and Eagan (1), 5 to 10% of fatalities were due to pulmonary embolization. The orthopedic patient should be particularly prone to thrombo-embolic complications as he is subjected to considerable soft tissue trauma, muscular trauma, and lengthy immobilization. Indeed, this is the case. In a series of 389 hip operations reported by Tubiana and Duparc (2), thrombo-embolic complications involved 15% of the patients.Prophylactic anticoagulant therapy has been found...References1. MILCHBERMANEAGAN OLR: Bishydroxycoumarin (Dicumarol) prophylaxis. Arch. Surg. (Chicago) 8E: 444, 1961. CrossrefGoogle Scholar2. TUBIANADUPARC RJ: Prevention of thromboembolic complications in orthopedic and accident surgery. J. Bone Joint Surg. (Brit.) 43: 7, 1961. CrossrefGoogle Scholar3. CHALMERSMARKSBOTTOMBYLLOYD DBJJEO: Postoperative prophylactic anticoagulants, five year study in an obstetric and gynecological unit. Lancet 2: 220, 1960. CrossrefMedlineGoogle Scholar4. CRAFOORDJORPES CE: Heparin as a prophylactic agent against thrombosis. JAMA 116: 2831, 1941. CrossrefGoogle Scholar5. KISTNERSMITH RWGU: A ten year analysis of thromboembolism and Dicumarol prophylaxis. Surg. Genec. Obstet. 98: 437, 1954. MedlineGoogle Scholar6. MULLERTZSTORM SO: Anticoagulant therapy with Dicumarol maintained during major surgery. Circulation 10: 213, 1954. CrossrefMedlineGoogle Scholar7. SEVITTGALLAGHER SNG: Prevention of venous thrombosis and pulmonary embolism in injured patients. Lancet 2: 981, 1959. CrossrefMedlineGoogle Scholar8. SEVITT S: Venous thrombosis and pulmonary embolism. Amer. J. Med. 33: 703, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Springfield, MissouriFrom the Departments of Internal Medicine and Orthopedic Surgery, Smith-Glynn-Callaway Clinic, Springfield, Mo.Requests for reprints should be addressed to Leo T. Neu, Jr., M.D., Smith-Glynn-Callaway Clinic, 1211 S. Glenstone, Springfield, Mo. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByControlled trial of an anticoagulant (warfarin sodium) in the prevention of venous thrombosis following hip surgeryThe pathogenesis and prevention of thromboembolic complications in patients undergoing total hip replacementProspective randomized trial of sequential compression devices vs low-dose warfarin for deep venous thrombosis prophylaxis in total hip arthroplastyPulmonary thromboembolic diseaseTotal hip replacement arthroplasty in arthritic conditions of the hip jointSurgery on Patients Receiving AnticoagulantsPREVENTION AND DIAGNOSIS OF VENOUS THROMBOSIS IN PATIENTS WITH HIP FRACTURESAnticoagulants and AnticoagulationPrevention of venous thromboembolismThromboembolic Complications of Hip FracturesAnticoagulantsThe Value of Prophylactic Anticoagulant Therapy with Warfarin after Hip SurgeryThe Current Status of Therapy with AnticoagulantsSurgical management of arthritis of the hipThromboembolism After Elective Surgery of the HipDiagnosis and Management of Massive Pulmonary Embolism [ Abridged ]Orale AntikoagulantienDiagnosis and management of massive pulmonary embolismAnticoagulation for Prevention of Thromboembolism Following Fractures of the Hip 1 March 1965Volume 62, Issue 3Page: 463-467KeywordsAnticoagulant therapyCase seriesHipOintmentsOrthopedic surgeryOrthopedicsSoft tissues Issue Published: 1 March 1965 PDF DownloadLoading ...