tbuckley/cabot-search huggingface dataset:
Early treatment of HER2-amplified brain tumors with targeted NK-92 cells and focused ultrasound improves survival
Authors: Ryan Alkins, Alison Burgess, Robert Kerbel, Winfried S. Wels, Kullervo Hynynen
Journal: Neuro-Oncology (2016)

Malignant brain tumors have a dismal prognosis, with residual tumor remaining after surgery necessitating adjuvant chemoradiotherapy. The blood-brain barrier hinders many chemotherapeutic agents, resulting in modest treatment efficacy. We previously demonstrated that targeted natural killer (NK)-92 cells could be delivered to desired regions of the brain using MRI-guided focused ultrasound and Definity microbubbles. Targeted NK-92 cells have advantages over many systemic therapies including their specific cytotoxicity to malignant cells (particularly those expressing the target antigen), ability to spare healthy cells, and being unaffected by efflux channels. We investigated whether longitudinal treatments with targeted NK-92 cells, focused ultrasound, and microbubbles could slow tumor growth and improve survival in an orthotopic HER2-amplified rodent brain tumor model using a human breast cancer line as a prototype. The HER2 receptor, involved in cell growth and differentiation, is expressed by both primary and metastatic brain tumors. Breast cancers with HER2 amplification have a higher risk of CNS metastasis and poorer prognosis. Early intensive treatment with targeted NK-92 cells and ultrasound improved survival compared with biweekly treatments or either treatment alone. The intensive treatment paradigm resulted in long-term survival in 50% of subjects. Many tumor proteins could be exploited for targeted therapy with the NK-92 cell line; combined with the mounting safety evidence for transcranial ultrasound, these results may soon be translatable to a highly targeted treatment option for patients with brain tumors.
REAL-TIME 3D ECHOCARDIOGRAPHIC IMAGING OF THE TRICUSPID VALVE: VISUALIZATION RATES IN CONSECUTIVE PATIENTS
Authors: Amit Pursnani, Patrick Coon, Lynn Weinert, Georgeanne Lammertin, Heidi Pollard, Victor Mor-Avi, Roberto M. Lang, Lissa Sugeng
Journal: Journal of the American College of Cardiology (2010)
The Role of Self-Monitoring of Blood Glucose in the Routine Management of Children with Insulin-dependent Diabetes Mellitus
Authors: Denis Daneman, Linda Siminerio, David Transue, Jean Betschart, Allan Drash, Dorothy Becker
Journal: Diabetes Care (1985)

We report a double-crossover study to assess the impact of self-monitoring of blood glucose (SMBG) on the glycemic control of children with insulin-dependent diabetes mellitus (IDDM) on a conventional therapeutic regimen. Sixteen children were assigned to one of two groups—group A, period 1 (wk 1–13): urine testing plus SMBG; period 2 (wk 14–26): urine testing only; group B, period 1: urine only; period 2: urine testing plus SMBG. Frequent telephone contact was maintained throughout to help optimize insulin dose adjustment. At the outset, the two groups were similar in age, diabetes duration, and glycosylated hemoglobin levels (10.5 ± 0.6% and 9.5 ± 0.3% in groups A and B, respectively). No significant differences could be detected between the two groups at any stage of the study. There was, however, a trend toward lower mean blood glucose (MBG) concentration in both groups toward the end of the SMBG period. No complications of SMBG were noted, but compliance was a major problem in three children. SMBG confirmed symptoms of hypoglycemia in all children, and detected asymptomatic hypoglycemia (BG ≤ 40 mg/dl) in 11. Sixty-nine percent preferred SMBG to urine testing. We conclude that SMBG is an acceptable part of routine diabetes care in children. It is associated with very few complications and helps to confirm symptomatic hypoglycemia and detect asymptomatic hypoglycemia. However, the addition of SMBG to routine diabetes care does not necessarily lead to improved metabolic control.
Review of Essential Cardiology: A Primer
Authors: GERALD BURKE
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 March 1987Review of Essential Cardiology: A PrimerGERALD BURKE, M.D.GERALD BURKE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-3-482_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dr. Buckman's review ( 1 ) of Dr. Kannan's textbook, Essential Endocrinology: A Primer for Nonspecialists, ( 1 ) should not go unanswered.Most if not all multiauthored textbooks on endocrinology deservedly gather dust on library shelves. They do so because in all too many instances the expert contributors are either too far removed from clinical medicine to make their contributions intelligible and relevant or, alternatively, they are too busy and delegate the actual writing to a junior colleague. What emerges may meet Dr. Buckman's requirements for "scholarship," but like the proverbial camel created by committee, it...Reference1. BUCKMAN M. Essential endocrinology: a primer for nonspecialists [Book review]. Ann Intern Med. 1986; 105:989. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cook County Hospital Chicago, IL 60612-9985 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCorrection: Essential Endocrinology 1 March 1987Volume 106, Issue 3Page: 482-482KeywordsDustEndocrinologyLibraries Issue Published: 1 March 1987 PDF DownloadLoading ...
Leptomeningeal Tissue: a Barrier Against Brain Tumor Cell Invasion
Authors: Paal-Henning Pedersen, Garry J. Rucklidge, Sverre J. MØrk, A. Jorge A. Terzis, Olav Engebraaten, Morten Lund-Johansen, Erik-Olof Backlund, Ole D. Laerum, Rolf Bjerkvig
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Leptomeningeal Tissue: a Barrier Against Brain Tumor Cell Invasion Get access Paal-Henning Pedersen, Paal-Henning Pedersen Search for other works by this author on: Oxford Academic PubMed Google Scholar Garry J. Rucklidge, Garry J. Rucklidge Search for other works by this author on: Oxford Academic PubMed Google Scholar Sverre J. MØrk, Sverre J. MØrk Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Jorge A. Terzis, A. Jorge A. Terzis Search for other works by this author on: Oxford Academic PubMed Google Scholar Olav Engebraaten, Olav Engebraaten Search for other works by this author on: Oxford Academic PubMed Google Scholar Morten Lund-Johansen, Morten Lund-Johansen Search for other works by this author on: Oxford Academic PubMed Google Scholar Erik-Olof Backlund, Erik-Olof Backlund Search for other works by this author on: Oxford Academic PubMed Google Scholar Ole D. Laerum, Ole D. Laerum Search for other works by this author on: Oxford Academic PubMed Google Scholar Rolf Bjerkvig Rolf Bjerkvig Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 21, 2 November 1994, Pages 1593–1599, https://doi.org/10.1093/jnci/86.21.1593 Published: 02 November 1994 Article history Received: 17 February 1994 Revision received: 30 June 1994 Accepted: 11 August 1994 Published: 02 November 1994
Chekhov's Doctors 12. Vera
Authors: Jack Coulehan
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antibiotic Usage-Reply
Authors: Catherine M. Wilfert
Journal: JAMA (1978)

Dr Finley's comments are appreciated. The 50 patients whose records were reviewed were selected in a completely random manner. The appraisal of the antibiotic management was accomplished individually by three physicians prior to the assignment of the terms "inappropriate" or "appropriate." Examples of the criteria employed are (1) no evidence of infection and no indicated reason for prophylaxis, and (2) no bacterial cultures obtained, or an organism isolated but resistant to the drug employed. Antibiotics are one of the most frequently prescribed groups of drugs, and in the best interests of patient management, we must continue to use antimicrobial agents wisely to achieve effective therapy, to try to minimize the development of resistant organisms, and to reduce costs of treatment if two equally effective antimicrobial agents are available. These problems have been carefully considered in the report by Kunin et al.<sup>1</sup>In 1977 the ad hoc
Denial and the Discrepancy between Heart Rate and Reported Negative Affect: A Study of Convergent and Discriminant Validity
Authors: Randall S. Jorgensen, George E. Schreer, Lara Baskin, Monica Kolodziej
Journal: Psychotherapy and Psychosomatics (1992)

This study examined the convergent and divergent validity of heart-rate (HR)-based response discrepancy scores as measures of denial. After standardizing measures of stressor-related anxiety, hostility, and HR, response discrepancy scores were calculated by subtracting each measure of negative affect from the HR value. Analyses revealed the response discrepancy scores to correlate positively with measures of denial, negatively with a measure of trait anger, and to not correlate with measures of the nondefensive need for approval and the positive trait of curiosity. These findings support the construct validity of response discrepancy scores as markers of denial.
STUDIES ON THE ENTRY OF VIRUSES INTO THE CENTRAL NERVOUS SYSTEM OF MICE VIA THE CIRCULATION
Authors: Margret I. Sellers
Journal: The Journal of Experimental Medicine (1969)

The inhalation of CO(2) exerted a selective action on the entry of viruses into the CNS of mice via the circulation. In 6 wk old animals, the infectivity of poliovirus, vaccinia, and vesicular stomatitis viruses was enhanced, whereas the entry of herpesviruses and of a neurotropic influenza virus was not affected. However, in 3 to 4 wk old mice, inhalation of the gas enhanced the infectivity of all the viruses. To explain the relationship of age to the animals' response to CO(2), it was proposed that CO(2) inhalation, by increasing the rate of cerebral blood flow, served to increase the exposure of some extraneural cell(s) to virus, possibly the cerebrovascular endothelial cell, in which virus replicated and reached the brain parenchyma by direct extension of the infectious process. Consequent to maturation, the postulated target cell developed resistance to certain viruses, while its susceptibility to others remained unchanged. Inoculation of adrenalin or serotonin simultaneously with virus into the circulation enhanced the CNS infectivity of all the viruses tested in both 4 wk and 6 wk age groups of mice. The enhancing effects were completely inhibited by the action of an alpha-adrenergic blocking agent; it was therefore concluded that hemodynamic changes produced by the contractile response of the smooth muscle cells in the vessel walls mediated the enhancing effect. It was suggested that a vasopressor response invoked in the peripheral vessels, with a consequent increase in cerebral blood flow, increased virus dosage to the CNS. In addition, a direct effect of the vasoactive amine on the cerebral vessels, resulting in the disruption of an anatomical "barrier", was considered as a contributory factor in increasing the transfer of virus to the CNS from the circulation.
Points: Bone scintigraphy in benign bone disease
Authors: J. Chalmers
Journal: BMJ (1984)

which is more likely to be detrusor inhibition mediated at the level of the sacral cord "bladder centre."Further research is indicated to assess the interaction of both limbs of the autonomic nervous system with the various peptidergic systems in the control of lower urinary tract function to evaluate their future therapeutic importance.
Impact of improved treatment of sexually transmitted disease on HIV infection
Authors: Tarjei Rygnestad, Lars Småbrekke, Lars Nesje, Heidi Talsethagen, Per Rogne, Kirsten Myhr, Inge Bentzen, J.DikF. Habbema, SakeJ. de Vlas, MaryA. Foulkes, WasimaN. Rida, Rodney Hoff, Kevin O'Reilly, Antonio Gerbase, Thierry Mertens, Monir Islam, Luke Whitaker, Adrian Renton, Richard Hayes, Heiner Grosskurth, Gina ka-Gina
Journal: The Lancet (1995)
TCT-837 Effectiveness and possible complications of post dilatation in patients with residual significant aortic regurgitation following valve implantation using both Edwards and Corevalve systems: A single center study
Authors: Ahmed Rezq, Azeem Latib, Sandeep Basavarajaiah, Kensuke Takagi, Tasuku Hasegawa, Antonio Colombo
Journal: Journal of the American College of Cardiology (2012)
Points from Letters: Additional Sessions for Consultants
Authors: J. B. Fawcitt
Journal: BMJ (1975)

vogue in the future should Parliament as at present constituted beconme too unwieldy to function effectively.Moreover, the medical profession would be freer to set up and supervise what mtust surely come, and that is a body of aware persons to interview at regular intervals all persons in paid authority above a certain level of responsibility, in- cluding doctors, lawyers, M.P.s, teachers, etc., regairding their continuing suitability to hold such authority.Under the pro- fession's present subservience to politics this would be difficult to implement, if at all."What shall it profit a man if he shall gain the whole world and lose his own soul?"And as a profession we are in grave danger of doing just that.-I am, etc.,
The Medical Care of Mentally Retarded Persons in Public Residential Facilities
Authors: Richard P. Nelson, Allen C. Crocker
Journal: New England Journal of Medicine (1978)

Abstract Large public residential facilities have traditionally been society's primary service resource for persons with serious mental retardation. Despite current emphasis on restricting admissions and community placement of retarded persons, approximately 175,000 people continue to reside in 230 institutions throughout the United States. This population is vulnerable to a variety of chronic medical disorders that diminish successful adaptation to a more normal life-style, especially when health services are marginal. Institutional medical staffs have been largely isolated from their physician peers, and their patients have not had access to medical care equivalent to that available in the community. We describe the recent affiliation of a teaching hospital with a Massachusetts institution. We suggest that such affiliations would assure better medical care for mentally retarded persons while increasing physicians' knowledge of attendant medical and societal problems. (N Engl J Med 299:1039–1044, 1978)
Textbook of Child Neurology
Authors: Arthur L. Drew
Journal: JAMA (1974)

This, the latest offering in child neurology textbooks, is without question the best, and more than likely, it will become the most widely used in the specialty of child neurology. The author and his collaborators are to be congratulated on their clarity of expression. The liberal use of summary tables and outlines is a most valuable feature and is found in almost every chapter. This is particularly true in those sections dealing with the degenerative and metabolic diseases. As could be expected from Dr. Menkes' previous work, these two chapters are truly outstanding. Another innovative and very helpful feature is the frequent listing of key references to obscure and rare conditions that are not discussed in detail, thus preserving the clarity in presenting material more suitable for textbook inclusion. A good example of this editorial technique can be found in the chapter on "Toxic Disorders." The chapter by Ronald D.
Further studies on adenyl cyclase in psoriasis
Authors: MEI MEI MUI, S.L. HSIA, KENNETH M. HALPRIN
Journal: British Journal of Dermatology (1975)

Slices of human skin obtained with a keratome were pre-incubated with [3H]adenine to label the ATP pool from which cyclic AMP was subsequently formed. The accumulation of radioactive cyclic AMP was measured as an index of adenyl cyclase activity. The data showed that both the ability to incorporate [3H] into ATP and adenyl cyclase activity were significantly lower in psoriatic plaques than in uninvolved skin of the psoriatic patients, or in normal skin of control subjects. The response of adenyl cyclase to the stimulation of 3.3 muM adrenaline was less than five fold in psoriatic plaques as compared to twelve to thirty-two fold in the uninvolved skin. The response to the stimulation of prostaglandin E2 (5 mug/ml) showed no significant difference between the plaque and normal skin. The adenyl cyclase activity in uninvolved skin of psoriatic patients appeared normal. Propranolol (10 muM) blocked the stimulatory effect of adrenaline but not that of PGE2 in normal skin. These results suggest that the adenyl cyclase system of the skin has different regulatory sites for adrenaline and PGE2 and that the enzyme is defective in the epidermis of the psoriatic plaque, especially at the adrenaline regulatory site.
A Comparison of Rate Control and Rhythm Control in Patients with Recurrent Persistent Atrial Fibrillation
Authors: Isabelle C. Van Gelder, Vincent E. Hagens, Hans A. Bosker, J. Herre Kingma, Otto Kamp, Tsjerk Kingma, Salah A. Said, Julius I. Darmanata, Alphons J.M. Timmermans, Jan G.P. Tijssen, Harry J.G.M. Crijns
Journal: New England Journal of Medicine (2002)

Maintenance of sinus rhythm is the main therapeutic goal in patients with atrial fibrillation. However, recurrences of atrial fibrillation and side effects of antiarrhythmic drugs offset the benefits of sinus rhythm. We hypothesized that ventricular rate control is not inferior to the maintenance of sinus rhythm for the treatment of atrial fibrillation.
Interleukin-1 receptor type I gene-deficient bile duct-ligated mice are partially protected against endotoxin
Authors: Miguel E. Sewnath, Tom Van Der Poll, Fiebo J. W. Ten Kate, Cornelis J. F. Van Noorden, Dirk J. Gouma
Journal: Hepatology (2002)

Cholestatic liver injury is associated with an increased susceptibility toward endotoxin-induced toxicity. To determine the role of interleukin 1 (IL-1) herein, extrahepatic cholestasis was induced by bile duct ligation (bdl) in IL-1 receptor type I gene-deficient (IL-1R(-/-)) mice, which are unresponsive to IL-1alpha and IL-1beta, and normal IL-1R(+/+) mice. Bdl elicited increases in hepatic IL-1alpha and IL-1beta messenger RNA (mRNA) and protein. Hepatocellular injury at 2 weeks after bdl was similar in IL-1R(-/-) and IL-1R(+/+) mice as shown by clinical chemistry and histopathology. Administration of endotoxin to cholestatic mice at 2 weeks after bdl was associated with enhanced cytokine release, more severe liver damage, and occurrence of death when compared with sham-operated mice. Endotoxin effects in sham-operated IL-1R(-/-) and IL-1R(+/+) mice were largely similar, but cholestatic IL-1R(-/-) mice were better protected against toxic effects of endotoxin, as reflected by lowered cytokine release, less profound liver injury, and reduced mortality. These data indicate that IL-1alpha and IL-1beta are produced in the liver after bdl, but that these cytokines do not play a significant role in cholestatic liver damage; however, endogenous IL-1 activity is an important denominator of enhanced endotoxin sensitivity that is observed during cholestasis induced by bdl.
IT-31 * HARNESSING THE IMMUNOLOGIC CAPACITY OF THE LIVER AGAINST GLIOBLASTOMA MULTIFORME
Authors: E. Sayour, G. De Leon, C. Pham, L. Sanchez-Perez, D. Snyder, H. Kemeny, C. Flores, D. Mitchell
Journal: Neuro-Oncology (2014)

BACKGROUND: Glioblastoma multiforme (GBM) remains invariably associated with poor patient outcomes thus necessitating the development of more targeted therapeutics. To circumvent the challenges associated with cellular therapeutics, we have utilized clinical-grade nanoparticle (NP) vaccine formulations that are known to traffic through the liver. Since the liver is a profoundly important lymphoid organ enriched with innate immune cells that must function in the dualistic role of tolerance when constitutively engaged by gastrointestinal ligands and heighted inflammatory responses when engaged by viral elements, it represents a profound immunological niche for re-directing the immune system in the presence of specific ‘danger’ signals. Therefore, using tumor derived RNA from intracranial gliomas, imbued with the appropriate immunomodulatory RNAs packaged into an "off the shelf" NP vaccine formulation, we aim to harness the liver's immunologic potential against GBM. METHODS: We sought to assess if vaccination with autologously derived total tumor RNA encapsulated in lipophilic NPs could transfect liver antigen-presenting cells (APCs) and induce anti-tumor immunity in pre-clinical immunocompetent murine GBM models. RESULTS: We screened clinically available nanoliposomal formulations, identified a suitable NP courier for delivery of encapsulated RNA to liver APCs, and demonstrated effective anti-tumor activity against murine GBMs. These NPs were shown to preferentially transfect hepatic cells and APCs therein generating a preponderance of antigen specific T cell immunity against tumor antigens. The percentage of antigen specific T cells was greater from harvested livers compared with harvested secondary lymphoid organs. Moreover, we demonstrated the capacity to significantly enhance the immunity and anti-tumor efficacy of this platform through incorporation of immunomodulatory RNAs encoding for cytokines such as GM-CSF. CONCLUSION: RNA-NPs represent a novel therapeutic platform for inducing potent nontoxic immunity against gliomas by harnessing the immunologic potential of the liver, thus providing a more effective and specific therapy critical in improving clinical outcomes for patients with GBM.
Utopian Ideals of Francis Bacon-Reply
Authors: Lester S. King
Journal: JAMA (1963)

As the author of the editorial, I greatly regret that a misunderstanding arose. What I intended very literally, you interpreted in a metaphorical sense. When I used the phrase  ideals, I was referring specifically to The New Atlantis , which represents Bacon's contribution to so-called utopian thought. This work ranks with More's classic, as a blueprint of the idealized state. Such   we may very properly contrast with the studies on scientific methodology.  I thoroughly agree with your comments regarding these other writings of Francis Bacon. In fact, I yield to no one in my admiration of his penetrating intellect and influence on later thought.  To this, Dr. Sager adds a comment.  Perhaps we should allow Bacon the last word. In De Augmentis he quotes from Virgil:  Two gates the entrance of sleep's house adorn Of ivory one, the other simple horn; Through horn a crowd of real visions