tbuckley/cabot-search huggingface dataset:
Pyridoxine Dependency Convulsions in a Newborn
Authors: M. Moreno Robins
Journal: JAMA (1966)

THE FOLLOWING ARTICLE is written to draw to the attention of all physicians a clinical syndrome which can lead to severe mental retardation or death in the neonate if it goes unrecognized, while early recognition and treatment will result in dramatic and prompt relief of symptoms and subsequent normal development. Two case reports from one family serve as illustrative examples of the diagnostic problems, therapy, and prognosis. The patient in case 1 is suspected of having had the disorder although there is no actual proof of this. Case 2 illustrates most of the characteristic symptoms of the syndrome with a dramatic response to therapy. <h3>Report of Cases</h3><h3>Case 1.—</h3> This male infant was born Oct 22, 1962 after a full-term uncomplicated pregnancy. The delivery was precipitous and the child was apneic and cyanotic at birth. During the night he was reported to have had intermittent irregularities of breathing, tonic seizures,
The Future of Pharmacotherapy New Drug Delivery Systems
Authors: Harold A. Abramson
Journal: JAMA (1973)

This reviewer has always gained new knowledge from the writings of Dr. Ayd. This volume is no exception. Dr. Ayd and his group ably present their data and their views on longacting antipsychotic drugs. Emphasis is placed on the extreme need for long-acting depot injectable neuroleptics. The injectable single-depot dose, lasting for weeks, may comprise only 1% or less of the oral dose required to maintain the psychotic patient in an ambulatory state outside the hospital. Twenty percent of the psychotic patients, including those who are orhave been in mental hospitals, do not take their neuroleptic medication. It is this group of drug defectors that most frequently require readmission to the hospital. The contributors to the book show that psychotics of all age groups, with both acute and chronic disturbances, can be treated effectively and economically. The data primarily deal with depot fluphenazine enanthate and fluphenazine decanoate. Dr. Ayd predicts
Selective Inducible Nitric Oxide Synthase Inhibition Has No Effect on Allergen Challenge in Asthma
Authors: Dave Singh, Duncan Richards, Richard G. Knowles, Sheila Schwartz, Ashley Woodcock, Steve Langley, Brian J. O'Connor
Journal: American Journal of Respiratory and Critical Care Medicine (2007)

Exhaled breath nitric oxide (Fe(NO)) is increased in asthma. NO is produced predominantly by inducible nitric oxide synthase (iNOS).We evaluated the selective and potent iNOS inhibitor GW274150 in asthma.Twenty-eight steroid-naive patients with asthma participated in a double-blind, randomized, double-dummy, placebo-controlled, three-period cross-over study. Subjects received GW274150 (90 mg), montelukast (10 mg), or placebo once daily for 14 days. Fe(NO) was assessed predose on Days 1, 7, 10, and 14. Adenosine 5'-monophosphate (AMP) challenge was performed on Day 10, allergen challenge on Day 14 followed by methacholine challenge (MCh) 24 hours later, and then bronchoscopy.GW274150 reduced predose Fe(NO) by 73, 75, and 71% on Days 7, 10, and 14, respectively, compared with placebo. Montelukast did not reduce Fe(NO). GW274150 did not inhibit AMP reactivity whereas for montelukast there was a trend toward inhibition: the mean doubling dose difference versus placebo was 0.64 (95% confidence interval [95% CI], 0 to 1.28). GW274150 did not inhibit early (EAR) and late (LAR) asthmatic responses to allergen, or MCh reactivity, despite reduced Fe(NO) levels. Montelukast inhibited EAR and LAR FEV1; the mean difference versus placebo for minimal FEV1 was 0.37 L (95% CI, 0.19 to 0.55) and 0.18 L (95% CI, 0.04 to 0.32), respectively. MCh reactivity was inhibited by montelukast (mean doubling dose difference vs. placebo, 0.51; 95% CI, 0.02 to 1.01). GW271540 also had no effect on inflammatory cell numbers in bronchoalveolar lavage fluid after allergen challenge.Selective iNOS inhibition effectively reduces Fe(NO) but does not affect airway hyperreactivity or airway inflammatory cell numbers after allergen challenge in subjects with asthma. Clinical trial registered with www.clinicaltrials.gov (NCT00273013).
Monoclonal Antibodies to Endotoxin New Allies Against Sepsis?
Authors: Roger C. Bone
Journal: JAMA (1991)

Both Greenman et al<sup>1</sup>and Ziegler et al<sup>2</sup>recently reported studies of major importance. Both studies found that monoclonal antibodies to endotoxin can reduce mortality and increase the reversal of multiorgan failure in some patients with gram-negative sepsis. This is welcome news, given that sepsis is increasing in incidence and its associated mortality remains high despite the use of potent antibiotics, fluid resuscitation, and vasoactive agents.<sup>3</sup> Unfortunately, neither monoclonal antibody was effective in all patients to whom it was given, and each antibody was effective in a different subgroup of patients. Although their prices have not been announced, both products are expected to be costly. Thus, physicians will be faced with several dilemmas when these agents are approved for use. The first dilemma involves cost. I believe that monoclonal antibodies to endotoxin will prove to be extremely helpful in the management of gram-negative
Corrigendum to ‘Bladder tissue regeneration using acellular bi-layer silk scaffolds in a large animal model of augmentation cystoplasty’ [Biomaterials 34 (2014) 8681–8689]
Authors: Duong D. Tu, Yeun Goo Chung, Eun Seok Gil, Abhishek Seth, Debra Franck, Vivian Cristofaro, Maryrose P. Sullivan, Dolores Di Vizio, Pablo Gomez, Rosalyn M. Adam, David L. Kaplan, Carlos R. Estrada, Joshua R. Mauney
Journal: Biomaterials (2014)
CLINICAL AND ANGIOGRAPHIC CHARACTERISTICS OF VASOSPASTIC ANGINA IN TEENAGERS
Authors: Amro Elnagar, Seung-Woon Rha, Byoung Geol Choi, sung il Im, Sunwon Kim, Jin Oh Na, Seongwoo Han, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Hong-Seog Seo, Chang Gyu Park, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2012)
COMPARISON OF RAPID SEQUENCE (2 MIN.) VS. TIME LAPSE (EVERY 10 MIN.) IMAGING IN THE IDENTIFICATION OF HEPATOBILIARY STRUCTURES
Authors: S. White, M. Eklem, K. Langrell, H. Smith, V. R. Bobba, G. T. Krishnamurthy
Journal: Clinical Nuclear Medicine (1982)

White, S.; Eklem, M.; Langrell, K.; Smith, H.; Bobba, V. R.; Krishnamurthy, G. T. Author Information
A Clinical Lecture ON A CASE OF HERNIA STRANGULATED IN THE FORAMEN OF WINSLOW: AND THE TREATMENT OF GREATLY-DISTENDED SMALL INTESTINE: Delivered at the Bristol General Hospital
Authors: C. A. Morton
Journal: BMJ (1909)

GENTLEMEN,-The form of internal hernia, an instance of which I am about to describe-hernia into the foramen of Winslow-is a very rare form.There are only about a dozen cases on record (one was reported by Mr. Carwardine in the Infirmary last year), and there is only one suc- cessful case of operation for strangulation in this hernia.My own case was unfortunately not successful, but all the symptoms of strangulation were relieved by the release of the strangulated bowel from the foramen, and the patient seemed almost certain to recover, when, seven days after the operation, he died a few hours after developing serious symptoms, and we found post mortem some pelvic periton- itis, due to leakage at the attachment of the opened bowel to the parietal peritoneum, into the pelvic cavity.This certainly did not seem sufficient to cause his death, for he was a strong, middle-aged man, but nothing else was found post mortem that would account for it.Mr. W. was seen in consultation with Dr. Burroughs at 12.30
Nuclear Medicine in Clinical Diagnosis and Treatment, vols 1 &amp;amp; 2
Authors: Jesus A. Bianco
Journal: JAMA (1995)

This encyclopedic pair of volumes contains 114 chapters by a renowned international mix of contributors, who have discussed in a direct manner the scientific bases of clinical nuclear medicine. Clinical nuclear medicine, of course, has grown exponentially since the early 1970s, when bone scanning, cardiovascular nuclear medicine, and reconstructive tomography allowed it to embark on a prolonged and continuing period of growth. More recently, we have seen major advances in radiopharmaceutical design with wonderful new tracers, novel positron emission tomography (PET) investigations of neuroreceptors, great interest in tumor imaging, and, just now, heightened expectations of a revolution in single photon emission computed tomography (SPECT) instrumentation, such as fan-beam collimation for multidetector systems with capabilities for attenuation and scatter corrections. The textbook edited by Drs Murray and Ell builds upon this incredible development in clinical nuclear medicine during the past 25 years. The first 20 chapters cover the clinical nuclear medicine
Do You Know Pain?
Authors: Kyle Potvin
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lethal endotoxin shock. Oxygen deficit, lactic acid levels, and other metabolic changes
Authors: J. C. Rosenberg
Journal: JAMA (1966)

Recent studies by Crowel<sup>1</sup>and Smith<sup>1</sup>and Rush et al<sup>2</sup>have drawn attention to the significance of the oxygen deficit incurred during hemorrhagic shock. The results of these investigations support the concept of progressive stagnant hypoxia as the final pathway of irreversible hemorrhagic shock.<sup>3</sup>Endotoxin shock is thought to produce death in a similar fashion, ie, vasoactive substances are released which lead to venous pooling, decreased venous return, decreased cardiac output, and poor tissue perfusion. The latter results in stagnant hypoxia with eventual cellular death. The following experiments were undertaken to quantitate the hypoxia sustained during lethal endotoxin shock by measuring oxygen deficit and lactate production following the administration of<i>Escherichia coli</i>endotoxin. The data reported in this paper were derived from animals that did not develop a pyrogenic response to the endotoxin. If shock was accompanied by fever, oxygen consumption rose, despite progressive deterioration terminating in
Duration of Cardiopulmonary Resuscitation and Illness Category Impact Survival and Neurologic Outcomes for In-hospital Pediatric Cardiac Arrests
Authors: Renée I. Matos, R. Scott Watson, Vinay M. Nadkarni, Hsin-Hui Huang, Robert A. Berg, Peter A. Meaney, Christopher L. Carroll, Richard J. Berens, Amy Praestgaard, Lisa Weissfeld, Philip C. Spinella
Journal: Circulation (2013)

Background— Pediatric cardiopulmonary resuscitation (CPR) for &gt;20 minutes has been considered futile after pediatric in-hospital cardiac arrests. This concept has recently been questioned, although the effect of CPR duration on outcomes has not recently been described. Our objective was to determine the relationship between CPR duration and outcomes after pediatric in-hospital cardiac arrests. Methods and Results— We examined the effect of CPR duration for pediatric in-hospital cardiac arrests from the Get With The Guidelines–Resuscitation prospective, multicenter registry of in-hospital cardiac arrests. We included 3419 children from 328 US and Canadian Get With The Guidelines–Resuscitation sites with an in-hospital cardiac arrest between January 2000 and December 2009. Patients were stratified into 5 patient illness categories: surgical cardiac, medical cardiac, general medical, general surgical, and trauma. Survival to discharge was 27.9%, but only 19.0% of all cardiac arrest patients had favorable neurological outcomes. Between 1 and 15 minutes of CPR, survival decreased linearly by 2.1% per minute, and rates of favorable neurological outcome decreased by 1.2% per minute. Adjusted probability of survival was 41% for CPR duration of 1 to 15 minutes and 12% for &gt;35 minutes. Among survivors, favorable neurological outcome occurred in 70% undergoing &lt;15 minutes of CPR and 60% undergoing CPR &gt;35 minutes. Compared with general medical patients, surgical cardiac patients had the highest adjusted odds ratios for survival and favorable neurological outcomes, 2.5 (95% confidence interval, 1.8–3.4) and 2.7 (95% confidence interval, 2.0–3.9), respectively. Conclusions— CPR duration was independently associated with survival to hospital discharge and neurological outcome. Among survivors, neurological outcome was favorable for the majority of patients. Performing CPR for &gt;20 minutes is not futile in some patient illness categories.
Blood Pressure Recording In the Tense Patient
Authors: Hans H. Neumann
Journal: JAMA (1974)

To the Editor.—  Dr. Klinefelter described (226:81, 1973) a practical maneuver that can produce quick relaxation in a tense patient, before measuring his blood pressure. This consisted of a few preliminary deep breaths. I have used this method for many years and have often been impressed by the rapid reduction of the pressure after such deep breathing. Some apprehensive patients tend to undergo contraction of muscles, including diaphragms, and to hold the breath in reaction to some fear provoked by the taking of the blood pressure.  In my opinion, the explanation does not lie in the effect of hyperventilation or associated change in the blood oxygen or carbon dioxide tension, but merely in a state of muscle relaxation (including the diaphragm), combined with the diversion created by taking two deep breaths.  I believe that Dr. Klinefelter's suggestion should be followed whenever there are doubts about an elevated pressure reading.
Erythema multiforme due to griseofulvin
Authors: M.H.A. RUSTIN, C.B. BUNKER, PAULINE M. DOWD, T.W.E. ROBINSON
Journal: British Journal of Dermatology (1989)

Journal Article Erythema multiforme due to griseofulvin Get access M.H.A. RUSTIN, M.H.A. RUSTIN Department of Dermatology, University College and Middlesex School of Medicine, The Middlesex Hospital, Mortimer Street, London W1N 8AA, U.K. Dr M.H.A. Rustin, Department of Dermatology, The Middlesex Hospital, Mortimer Street, London W1N 8AA Search for other works by this author on: Oxford Academic Google Scholar C.B. BUNKER, C.B. BUNKER Department of Dermatology, University College and Middlesex School of Medicine, The Middlesex Hospital, Mortimer Street, London W1N 8AA, U.K. Search for other works by this author on: Oxford Academic Google Scholar PAULINE M. DOWD, PAULINE M. DOWD Department of Dermatology, University College and Middlesex School of Medicine, The Middlesex Hospital, Mortimer Street, London W1N 8AA, U.K. Search for other works by this author on: Oxford Academic Google Scholar T.W.E. ROBINSON T.W.E. ROBINSON Department of Dermatology, University College and Middlesex School of Medicine, The Middlesex Hospital, Mortimer Street, London W1N 8AA, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 120, Issue 3, 1 March 1989, Pages 455–458, https://doi.org/10.1111/j.1365-2133.1989.tb04174.x Published: 01 March 1989
Hypertrophic cardiomyopathy: Combination of β blockers and verapamil may be risky
Authors: Javier Borja, Iñaki Izquierdo, Josep Guindo
Journal: BMJ (2006)

EDITOR—Spirito and Autore recommend β blockers or verapamil, or the two drugs combined, to control heart rate in patients with hypertrophic cardiomyopathy and chronic atrial fibrillation. To recommend the combination …
Cardiovascular Mortality and Duration of Androgen Deprivation for Locally Advanced Prostate Cancer: Analysis of RTOG 92-02
Authors: Jason A. Efstathiou, Kyounghwa Bae, William U. Shipley, Gerald E. Hanks, Miljenko V. Pilepich, Howard M. Sandler, Matthew R. Smith
Journal: European Urology (2008)
Genomics and Medicine: Distraction, Incremental Progress, or the Dawn of a New Age?
Authors: Richard S. Cooper, Bruce M. Psaty
Journal: Annals of Internal Medicine (2003)

The technology of molecular genetics has profoundly altered the conduct of biomedical research. An entire universe of problems that in the past had been addressed only through conjecture, including whole genome analysis, can now be studied directly. The rapidity and scope of these changes in research capacity have in turn led to speculation that medicine will be radically altered by the application of genomics to everyday practice. To date, gene therapy and several new tests for genetic susceptibility have been successfully implemented, although their impact on medicine as a whole remains very limited and their future contribution is hotly contested. The potential of molecular genetics, like all technology, must be evaluated on the basis of established principles of clinical and epidemiologic research. The rhetoric of some enthusiasts focuses instead on an optimistic best-case scenario of the future of DNA science, and many of their most far-reaching claims cannot be substantiated on the basis of what is currently known. The tension between the long-term goal of public health and medicine to identify and remove the causes of ill health, in contrast to the development of technological innovations that can cure disease or identify individual susceptibility, emerges as a major theme in this debate.
Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse
Authors: Donna M. Dambach, Linda M. Watson, Kevin R. Gray, Stephen K. Durham, Debra L. Laskin
Journal: Hepatology (2002)

The biological effects of monocyte chemoattractant protein (MCP) 1 are mediated by binding to C-C chemokine receptor (CCR) 2. In the present studies, we used CCR2 knockout (CCR2-/-) mice to examine the role of MCP-1 in acetaminophen-induced macrophage accumulation in the liver, expression of inflammatory cytokines, and hepatotoxicity. We found that hepatic expression of CCR2 and MCP-1 was increased 10-fold and 20-fold, respectively, 12 to 72 hours after administration of acetaminophen to wild-type mice. Expression of these proteins was localized in centrilobular regions of the liver. Whereas MCP-1 was expressed by both hepatocytes and macrophages, CCR2 was identified in inflammatory macrophages. F4/80 is a marker of mature macrophages expressed in large quantities by Kupffer cells. In wild-type mice, a 75% decrease in F4/80-positive macrophages was observed 24 to 48 hours after administration of acetaminophen. In contrast, expression of macrosialin (CD68), a marker of activated macrophages, increased 2-fold 24 to 72 hours after administration of acetaminophen and was associated with inflammatory cells. Although there was a decrease in the overall severity of inflammation and in the number of macrosialin-positive macrophages 72 hours after administration of acetaminophen in CCR2-/- mice, the number of F4/80-positive cells did not change. Loss of CCR2 was also found to alter acetaminophen-induced expression of tumor necrosis factor alpha, monocyte chemoattractant protein 3, and KC/gro. However, the overall outcome of acetaminophen-induced hepatic injury was not affected. In conclusion, these data indicate that MCP-1 and CCR2 contribute to the recruitment of a subset of activated macrophages into the liver during acetaminophen-induced hepatotoxicity that may be important in resolution of tissue injury.
Injuries at the BMX Cycling European Championship, 1989.
Authors: T Brøgger-Jensen, I Hvass, S Bugge
Journal: British Journal of Sports Medicine (1990)

At the BMX Cycling European Championship in 1989 with 976 participants of both sexes, aged between six and 40 years, all injuries were registered. A total of 6.3% of the participants sustained injuries (1.6% per individual start), 52.5% required medical attendance and 3.3% necessitated hospital admission. Women were injured twice as frequently as men. Most injuries, 72.1%, were minor, 6.6% were fractures with 75% of the fractures affecting the upper limbs. BMX bicycle riding has the high injury risk of 1190 injuries per 1000 competition hours.
Has general practitioner computing made a difference to patient care? A systematic review of published reports
Authors: F. Sullivan, E. Mitchell
Journal: BMJ (1995)

Objective : To review findings from studies of the influence of desktop computers on primary care consultations. Design : Systematic review of world reports from 1984 to 1994. Setting : The computerised catalogues of Medline, BIDS, and GPlit were searched, as well as conference proceedings, books, bibliographies, and references in books and journal articles. Subjects : 30 papers met the inclusion criteria and were included for detailed review. Interventions : A validated scheme for assessing methodological adequacy was used to score each paper. Main outcome measures : Papers were rated on sample formation, baseline differences, unit of allocation, outcome measures, and follow up. Differences in outcomes were also recorded. Results : Four of the six papers dealing with the consultation process showed that consultations took longer. Doctor initiated and "medical" content of consultations increased at the expense of a reduction in patient initiated and "social" content. Each of the 21 studies which looked at clinician performance showed an improvement when a computer was used (from 8% to 50%, with better results for single preventive measures). Only one of the three studies looking at patient outcomes showed an improvement (diastolic blood pressure control 5 mm Hg better after one year, with fewer doctor-patient consultations). Conclusions : Using a computer in the consultation may help improve clinician performance but may increase the length of the consultation. More studies are needed to assess the effects on patient outcomes of using a computer in consultations.