Nasal Carriage of Staphylococcal Infection in Wegener Granulomatosis
Authors: Coen A. Stegeman, Jan Willem Cohen Tervaert, Cecs G. M. Kallenberg
Journal: Annals of Internal Medicine (1994)

Letters1 July 1994Nasal Carriage of Staphylococcal Infection in Wegener GranulomatosisCoen A. Stegeman, MD, Jan Willem Cohen Tervaert, MD, PhD, and Cecs G. M. Kallenberg, MD, PhDCoen A. Stegeman, MDUniversity Hospital Groningen; Groningen, the NetherlandsSearch for more papers by this author, Jan Willem Cohen Tervaert, MD, PhDUniversity Hospital Groningen; Groningen, the NetherlandsSearch for more papers by this author, and Cecs G. M. Kallenberg, MD, PhDUniversity Hospital Groningen; Groningen, the NetherlandsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-1-199407010-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Lawyer and colleagues raise interesting points regarding the possible role of S. aureus in the autoimmunity to proteinase-3 in patients with Wegener granulomatosis. Because proteinase-3 shows significant homology with different members of the human serine proteases family such as T-cell granzymes, leukocyte elastase, cathepsin G and (chymo)trypsin, the possibility of shared epitopes exists [1, 2]. The induction of granzyme B in cytotoxic T lymphocytes by staphylococcal enterotoxin A would therefore be a possible link between antiproteinase-3 Wegener granulomatosis and S. aureus.Evidence suggests, however, that the antiproteinase-3 antibody associated with Wegener granulomatosis is not directed to other ...References1. Niles JL, McCluskey RT, Ahmad MF, Arnaout MA. Wegener's granulomatosis autoantigen is a novel neutrophil scrine proteinase. Blood. 1989; 74:1888-93. Google Scholar2. Campanelli D, Melchior M, Fu Y, Nakata N, Shuman H, Nathan C, et al. Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils. J Exp Med. 1990; 172:1709-15. Google Scholar3. Goldschmeding R, van der Schoot CE, ten Bokkel Huinink D, Hack CE, van den Ende ME, Kallenberg CG, et al. Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils. J Clin Invest. 1989; 84:1577-87. Google Scholar4. Goldschmeding R, Vroom TM, Tesselaar NA, von dem Borne AE. Species and tissue distribution of proteinase 3, the target antigen of Wegener autoantibodies (ANCA). In: Goldschmeding R. Target Antigens of Antineutrophil Cytoplasmic Antibodies. Amsterdam: University of Amsterdam; 1992:85-97. Google Scholar Author, Article, and Disclosure InformationAffiliations: University Hospital Groningen; Groningen, the Netherlands PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byANCA-associated vasculitides—lessons from the adult literatureHypotheses on the Etiology of Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis: The Cause Is Hidden, but the Result Is KnownAnti-Neutrophil Cytoplasm-Associated Glomerulonephritis 1 July 1994Volume 121, Issue 1Page: 74-75KeywordsAntigensAutoimmunityEnzyme linked immunosorbent assayLymphocytesProteinsSerine proteasesSerum proteinsStaphylococcal infectionT cellsWegener granulomatosis ePublished: 15 August 2000 Issue Published: 1 July 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...