Hyperpnea, Hyperventilation, and Brain Dysfunction
Authors: FRED PLUM
Journal: Annals of Internal Medicine (1972)

Editorial Notes1 February 1972Hyperpnea, Hyperventilation, and Brain DysfunctionFRED PLUM, M.D.FRED PLUM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-2-328 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the 19th century, when Cheyne (1818) first noted periodic breathing and Biot (1876) dubbed ataxic breathing "meningitic," perceptive clinicians have recognized that abnormal respiratory patterns can reflect serious dysfunction of the brain and often imply a poor prognosis. Rout, Lane, and Wollner (1) have recently refocused attention on these important principles in studies of patients with strokes, supplementing graphs of the abnormal breathing patterns with analyses of the respiratory gases and acid-base balance in the blood and cerebrospinal fluid. Patients with normal respiratory patterns and blood gases survived, while those with Cheyne-Stokes breathing or hyperventilation fared badly: out of...References1. ROUTLANEWOLLNER MDL: Prognosis in acute cerebrovascular accidents in relation to respiratory pattern and blood gas tensions. Br Med J 3:7-9, 1971 CrossrefMedlineGoogle Scholar2. HUANGCOOKLYONS CAH: Severe cranio cerebral trauma and respiratory abnormalities. Arch Neurol 9:545-554, 1963 CrossrefMedlineGoogle Scholar3. VAPALAHTITROUP MH: Prognosis for patients with severe brain injuries. Br Med J 3:404-407, 1971 CrossrefMedlineGoogle Scholar4. LANEROUTWILLIAMSON DMD: Mechanism of hyperventilation in acute cerebrovascular accidents. Ibid., pp. 9-12 Google Scholar5. BROWNPLUM HF: The neurologic basis of Cheyne-Stokes respiration. Am J Med 30:849-860, 1961 CrossrefGoogle Scholar6. PLUMSWANSON FA: Central neurogenic hyperventilation in man. Arch Neurol Psychiat 81:535-549, 1959 CrossrefGoogle Scholar7. PLUM F: Neurological integration of behavioral and metabolic control of breathing, in Breathing: Hering-Breuer Centenary Symposium, Ciba Symposium, edited by PORTER R. London, J. & A. Churchill, Ltd., 1970, pp. 159-174 CrossrefGoogle Scholar8. DUCKERSIMMONSANDERSON TRR: Increased intracranial pressure and pulmonary edema. Part 3: the effect of increased intracranial pressure on the cardiovascular hemodynamics of chimpanzees. J Neurosurg 29:475-483, 1968 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FRED PLUM, M.D.Affiliations: Department of Neurology New York Hospital/Cornell Medical Center New York, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChallenges in the Anesthetic and Intensive Care Management of Acute Ischemic StrokeHypocapnia and HypercapniaWhat is the best definition of the term “hyperventilation”?Republished: Society for Neuroscience in Anesthesiology and Critical Care Expert Consensus Statement: Anesthetic Management of Endovascular Treatment for Acute Ischemic Stroke*Association of Intraprocedural Blood Pressure and End Tidal Carbon Dioxide with Outcome After Acute Stroke InterventionSociety for Neuroscience in Anesthesiology and Critical Care Expert Consensus StatementAssociation between initial prescribed minute ventilation and post-resuscitation partial pressure of arterial carbon dioxide in patients with post-cardiac arrest syndromeAssociation Between Postresuscitation Partial Pressure of Arterial Carbon Dioxide and Neurological Outcome in Patients With Post–Cardiac Arrest SyndromeRespiratory dysfunctionHypocapnia and the injured brain: More harm than benefitCan one Predict Outcome of Medical Coma?Stroke SyndromesHypocapniaNeurologic Causes of Acute Respiratory DysfunctionNeurologic Causes of Acute Respiratory DysfunctionRESPIRATORY DYSFUNCTION IN STROKEIntensive Care Evaluation of the Comatose PatientHirninfarktThe definition of “Cheyne-Stokes rhythms”A prospective study of nontraumatic coma: Methods and results in 310 patientsRespiratory rate and pattern disturbances in acute brain stem infarction.Respiratory Pattern Disturbances in Ischemic Cerebral Vascular DiseaseThe Mechanics of Breathing and Stabilization of Ventilation in Patients With Unilateral Cerebral InfarctionExtreme hypocapnia in the critically III patientCerebral Apoplexy (Stroke) Treated With or Without Prolonged Artificial Hyperventilation: 2. Cerebrospinal Fluid Acid-Base Balance and Intracranial Pressure 1 February 1972Volume 76, Issue 2Page: 328-328KeywordsBloodBrainBreathingCerebrospinal fluidStroke ePublished: 1 December 2008 Issue Published: 1 February 1972 PDF downloadLoading ...