Low Osmolar Contrast Agents and Nephrotoxicity
Authors: J. ROBERT EVANS
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 July 1987Low Osmolar Contrast Agents and NephrotoxicityJ. ROBERT EVANS, M.D., STEWART W. SHANKEL, M.D., RALPH E. CUTLER, M.D.J. ROBERT EVANS, M.D.Search for more papers by this author, STEWART W. SHANKEL, M.D.Search for more papers by this author, RALPH E. CUTLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-1-116_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: New intravascular radiographic contrast agents, iopamidol, iohexol, and ioxaglate all have lower osmolality than do older agents (1). Several authors have claimed that the low osmolar contrast agents are less toxic to the kidneys than are the older agents (1, 2). However, we observed three episodes of decreasing renal function closely associated with the use of two of the new agents. All three patients had diabetes mellitus, fundiscopic evidence of diabetic retinopathy, and renal insufficiency before coronary angiography was done.A 65-year-old woman was hospitalized with acute myocardial infarction. Both a history and physical examination showed diffuse...References1. SPATARO R. Newer contrast agents for urography. Radiol Clin North Am. 1984;22:365-80. MedlineGoogle Scholar2. DAWSON P. Contrast agent nephrotoxicity: an appraisal. Br J Radiol. 1985;58:121-4. CrossrefMedlineGoogle Scholar3. HAMMONDFORLANDPHANEVANSCUTLER PSHJR. Drugs and the kidney. In: GONICK HC, ed. Current Nephrology. Vol 11. Chicago: Year Book Medical Publishers, Inc.; 1987. In press. Google Scholar4. CEDGARDHERLITZGETERUDATTMANAURELL SHKPM. Acute renal insufficiency after administration of low-osmolar contrast media [Letter]. Lancet. 1986;2:1281. CrossrefMedlineGoogle Scholar5. MISSONCUTLER RR. Radiocontrast-induced renal failure. West J Med. 1985;142:657-64. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Loma Linda University School of Medicine Loma Linda, CA 92350 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNephrotoxicity of ionic and nonionic contrast media in 1196 patients: A randomized trialNephrotoxic Risks of Renal Angiography: Contrast MediaAssociated Nephrotoxicity and Atheroembolism—A Critical ReviewPharmacologic Management of Shock-Induced Renal DysfunctionEffects of Femoral Arteriography and Low Osmolar Contrast Agents on Renal FunctionNephrotoxicity of Contrast Media following Cardiac Angiography: Pathogenesis, Clinical Course, and Preventive Measures, Including the Role of Low-Osmolality Contrast MediaIoxaglate in paediatric angiocardiographyCorrespondenceRandomized comparison of the cost and effectiveness of iopamidol and diatrizoate as contrast agents for cardiac angiographyRadiological contrast mediaAcute Renal Failure Caused by Low-Osmolar Radiographic Contrast Media in Patients with Diabetic Nephropathy 1 July 1987Volume 107, Issue 1Page: 116-116KeywordsAcute myocardial infarctionAngiographyDiabetes mellitusDiabetic retinopathyKidneysToxic agents Issue Published: 1 July 1987 PDF downloadLoading ...