tbuckley/cabot-search huggingface dataset:
Abstract P2-09-19: Zerumbone suppresses IL-1b-induced cell migration and invasion through inhibition of IL-8 expression and MMP3 expression in human triple negative breast cancer cells
Authors: SY Bae, JH Han, S Kim, SK Lee, JH Lee, HC Lee, M Kim, J Kim, WH Kil, SW Kim, JE Lee, SJ Nam
Journal: Cancer Research (2013)

Abstract Background: Inflammation is a key regulatory process in breast cancer progression and severity. Several studies have demonstrated that prolonged exposure of breast tumor cells to inflammatory cytokines leads to epithelial-mesenchymal transitions (EMT), which is the principle mechanism involved in metastasis and tumor invasion. Disruption of the signaling pathways involved in EMT may therefore provide an effective treatment strategy for currently difficult to treat or untreatable cancers such as TNBC. The interleukin (IL)-1 plays a pivotal role on breast cancer proliferation, invasion and/or inflammation. Here, we investigated the correlation of MMP-3 and IL-8 on IL-1b-induced cell migration and invasion as well as the inhibitory effect of zerumbone on IL-1β-induced MMP-3 and IL-8. Methods: Triple negative breast cancer cells (Hs578T and MDA-MB231) were cultured DMEM with 10% FBS and 1% antibiotics. The levels of IL-8 and MMP-3 mRNA were analyzed by real-time PCR. The levels of secreted IL-8 and MMP-3 protein expression were analyzed by ELISA and western blot analysis, respectively. Cell viabilities by drug were analyzed by MTT assay. Cell invasion and migration was detected by Boyden chamber assay. Results: The level of IL-8 and MMP-3 mRNA and protein expression significantly increased by IL-1β treatment in both Hs578T cells and MDA-MB231 cells. In addition, IL-1β-induced cell migration and invasion also increased in Hs578T and MDA-MB231 cells. On the other hand, the levels of basal and IL-1β-induced IL-8 and MMP-3 expression were decreased by zerumbone. Conclusion: IL-1β induces the migration and invasion of breast cancer cells through IL-8 and MMP-3 expression. These effects are significantly suppressed by zerumbone. Therefore, we suggest that zerumbone may act as a useful therapeutic agent for treatment of triple negative breast cancer. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P2-09-19.
Asthma Care in Canada
Authors: Rebecca Voelker
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ECHOCARDIOGRAPHIC CHARACTERISTICS OF MITRAL SUBVALVULAR APPARATUS IN THE PATIENTS WITH MITRAL REGURGITATION
Authors: Tomoko Tani, Yuya Ide, Toshiaki Toyoda, Tomohiro Nishino, Satoshi Honda, Shunsuke Funakoshi, Noriyuki Kimura, Kite Kim, Takeshi Kitai, Atsushi Kobori, Makoto Kinoshita, Natsuhiko Ehara, Atsushi Yamamuro, Shuichiro Kaji, Shigefumi Morioka, Yutaka Furukawa, Toru Kita
Journal: Journal of the American College of Cardiology (2011)
Relationship of HLA and platelet‐reactive antibodies in alloimmunized patients refractory to platelet therapy
Authors: Daniel B. Brubaker, Maxine Romine
Journal: American Journal of Hematology (1987)

Platelet crossmatching assays have been used to predict the outcome of platelet transfusions in alloimmunized patients by detecting antibodies against platelets. The transfusion failure of HLA-matched platelets predicted by platelet crossmatching may be related to HLA antibodies undetected by lymphocytotoxicity but detected by platelet immunoglobulin-binding assays or platelet-specific antibodies (both antibodies defined here as platelet-reactive antibodies). To differentiate platelet-reactive antibodies from lymphocytotoxic HLA antibodies, we used HLA characterized lymphocytes in parallel with platelets from individuals to form separate frozen panels. Sera from 10 allosensitized patients were studied in the lymphocyte panel by lymphocytotoxicity and in the platelet panel by enzyme-linked immunoassay (ELISA). By comparing pattern and percent wells reacting in each panel, lymphocytotoxic HLA antibodies and antibodies reactive with platelets in ELISA were detected separately. In all 10 allosensitized patients, platelet-associated antibodies were present and 7 had additional lymphocytotoxic HLA antibodies. Using this double parallel panel technique, we found platelet-reactive antibodies important in platelet alloimmunization, unrecognized by lymphocytotoxicity. These data indicate platelet-crossmatching be solely used in the selection of platelets for allosensitized patients.
Three-Phase Abdominal Scintigraphy in Lupus Vasculitis of the Gastrointestinal Tract
Authors: SHYH-JEN WANG, JUNG-LIANG LAN, WAN-YU LIN, REN-SHYAN LIU, SHIN-HWA YEH
Journal: Clinical Nuclear Medicine (1995)

Gastrointestinal vasculitis is a recognized but frequently misdiagnosed complication of systemic lupus erythematosus. The authors investigated the usefulness of three-phase Tc-99m pyrophosphate abdominal scintigraphy for identifying areas of vasculitis in patients with systemic lupus erythematosus who have gastrointestinal symptoms (diarrhea or abdominal pain). Among patients with gastrointestinal symptoms, 62 of 82 (75%) patients showed positive scan results, suggesting gastrointestinal vasculitis. Among patients without gastrointestinal symptoms, 6 of 43 (13%) patients showed positive scan results. Although three-phase Tc-99m pyrophosphate abdominal scintigraphy cannot provide a definite diagnosis of vasculitis of the gastrointestinal tract, it is a noninvasive and convenient method for suggesting and monitoring gastrointestinal vasculitis.
Progressive Encephalomyelitis With Rigidity and Myoclonus
Authors: Joana Damásio, M. Isabel Leite, Ester Coutinho, Patrick Waters, Mark Woodhall, Manuela A. Santos, Inês Carrilho, Angela Vincent
Journal: JAMA Neurology (2013)

Importance: Progressive encephalomyelitis with rigidity and myoclonus is characterized by rigidity, painful muscle spasms, hyperekplexia, and brainstem signs.Recently, glycine receptor alpha 1 antibodies have been described in adult patients with progressive encephalomyelitis with rigidity and myoclonus.We describe a pediatric case.Observations: A 14-month-old child developed startleinduced episodes of generalized rigidity and myoclonus, axial hyperextension, and trismus, without impairment of consciousness.Episodes occurred during wakefulness and sleep, lasted seconds, and were accompanied by moaning, tachypnea, and oxygen desaturation.Imaging, cerebrospinal fluid, endocrine, metabolic, and genetic screening findings were normal or negative.She was treated with intravenous steroids and immunoglobulins with resolution of symptoms, but she relapsed weeks later.At this time, episodes were more severe.Glycine receptor alpha 1 antibodies were found in serum (titer of 1:200, later 1:320) and cerebrospinal fluid (titer of 1:2).Treatment was restarted with intravenous steroids and immunoglobulins, with major improvement, and she began treatment with oral steroids.She had 4 milder relapses, with improvement after treatment adjustments.Conclusions and Relevance: To our knowledge, this is the first pediatric case of progressive encephalomyelitis with rigidity and myoclonus associated with glycine receptor alpha 1 antibodies, a potentially severe but treatable antibody-mediated neurological disorder.
Diagnostic Value of Endoscopic Cholangiopancreatography
Authors: Paul B. Dickinson
Journal: JAMA (1973)

Peroral cannulation of the duodenal papilla for purposes of cholangiography and pancreatography was successfully accomplished in 186 of 202 patients. A fiberduodenoscope was used to locate the duodenal papilla that was then cannulated under direct vision with a Teflon tube. Clinically relevant information was obtained in 71% of 45 jaundiced patients, 46% of 39 patients with recurrent biliary pain, and 81% of 118 patients with suspected pancreatic disease. The procedure was well tolerated. Early diagnosis of biliary tract obstruction resulted in prompt surgical intervention. Individuals with recurrent biliary pain were the most difficult to cannulate, but abnormalities were discovered that had not been demonstrated previously, despite extensive diagnostic efforts. Carcinoma of the pancreas can be diagnosed by endoscopic pancreatography at an early and operable stage.
Current Surgical Management of Neurologic Disease
Authors: Edward Tarlov
Journal: JAMA (1981)

This volume provides for nonneurosurgeons a useful overview of current neurosurgical treatment. The 28 chapters by 29 contributors include many neurosurgical disorders, selected so as to cover those in which changes in treatment or in neurosurgical attitudes have occurred. The chapters are usefully grouped according to congenital, neoplastic, vascular, traumatic, inflammatory, and acquired disorders. Newfield and Cottrell summarize neuroanesthetic management and intraoperative monitoring. McLaurin discusses the problems of infantile hydrocephalus. The difficult subject of syringomyelia, syringobulbia, and the Arnold-Chiari malformation is discussed from the microsurgical viewpoint by Rhoton. Hoffman describes the combined neurosurgical and plastic surgical operations now available to correct congenital craniofacial anomalies. In the section on neoplasms, the transphenoidal microsurgical treatment of pituitary adenomas is elegantly elucidated by Wilson. Chemotherapy for malignant gliomas is discussed by Walker. Pineal tumors are discussed by Stein, while metastatic brain tumors and tumors within the spinal cord are reviewed by Ransohoff and
The nature and incidence of injuries in morris dancers.
Authors: A R Tuffery
Journal: British Journal of Sports Medicine (1989)

Morris dancing includes several distinct forms of vigorous traditional dance with about 5000 amateur participants in the UK and Ireland. Questionnaires were sent to over 500 registered morris sides. The response rate was 29 per cent with 129 acute injuries and 47 chronic injuries including one fatality. The commonest acute injuries were to ankle (33 per cent) and calf (22 per cent). The back was the commonest site of chronic injury, with a high contribution from occupational and other sources. Morris dancing is a relatively low-risk activity, but injuries could be prevented by improving the fitness of dancers and selecting safer surfaces to dance on. The severity of injuries could probably be reduced by seeking more and better treatment.
Fluphenazine and Postherpetic Neuralgia
Authors: Howard I. Hurtig
Journal: JAMA (1990)

<h3>To the Editor.—</h3> Dr Murphy's<sup>1</sup>review of the treatment of postherpetic neuralgia makes a highly questionable statement about how to treat this difficult problem. Dr Murphy states that "current practice suggests that the combination of fluphenazine hydrochloride... combined with a tricyclic antidepressant... may be effective." Although he cautions against the casual use of fluphenazine because of its extrapyramidal side effects, his recommendation is nevertheless too permissive and therefore deserves a response. Fluphenazine has been popular in the treatment of various pain syndromes, but it has never been shown in control trials to be effective, especially in postherpetic neuralgia, whereas amitriptyline has passed the litmus test of a double-blind, randomized, crossover study.<sup>2</sup>Since the incidence of herpes zoster increases with age, this very same group of elderly is most prone to develop irreversible tardive dyskinesia. Therefore, a strict warning<i>against</i>the use of fluphenazine or any of the neuroleptic
THE USE OF NEAR-INFRARED SPECTROSCOPY TO IDENTIFY PATIENTS AT HIGH-RISK FOR PERI-PROCEDURAL MYOCARDIAL INFARCTION: RESULTS FROM THE COLOR REGISTRY
Authors: Cristiano Souza, Giora Weisz, Tomotaka Dohi, Annapoorna Kini, David Rizik, Emmanouil Brilakis, Simon Dixon, Michael Hendricks, Eric Powers, Fuyu Qiu, Bo Zheng, Ke Xu, Gregg Stone, Gary Mintz, James Muller, Akiko Maehara
Journal: Journal of the American College of Cardiology (2014)
Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes—proposal from the International/European LeukemiaNet Working Group for Flow Cytometry in MDS
Authors: A Porwit, A A van de Loosdrecht, P Bettelheim, L Eidenschink Brodersen, K Burbury, E Cremers, M G Della Porta, R Ireland, U Johansson, S Matarraz, K Ogata, A Orfao, F Preijers, K Psarra, D Subirá, P Valent, V H J van der Velden, D Wells, T M Westers, W Kern, M C Béné
Journal: Leukemia (2014)
A RECIPIENT OF MANY BLOOD TRANSFUSIONS
Authors: Silik H. Polayes
Journal: JAMA (1930)

The case to be presented is of interest because the life of the patient has been sustained by blood transfusions since September, 1927, and also because it lends itself for study with regard to certain important serologic problems related to blood transfusions. <h3>REPORT OF CASE</h3><h3>History.</h3> —A. S., a white man, aged 67, a Russian Jew, a tailor, was admitted to the Jewish Hospital of Brooklyn in the medical service of Dr. S. R. Blatteis, May 22, 1925, because of pain in the right upper quadrant and a rash on the skin of his chest and abdomen. For the past three weeks he had been treated by a physician at home for intercostal neuralgia and asthma. Five days before admission he had had a temperature of 104 F. and had vomited. On the day before admission he became irrational, and the high temperature persisted. On the night prior to admission
Abstract 4375: Sunitinib alone and in combination with SN-38 is active against anaplastic thyroid cancer
Authors: Guido Bocci, Teresa Di Desidero, Anna Fioravanti, Paola Orlandi, Bastianina Canu, Romano Danesi
Journal: Cancer Research (2012)

Abstract Background: Anaplastic thyroid cancer (ATC) is the most aggressive thyroid gland malignancy. Recent experimental evidences suggest a rationale for the use of multitarget tyrosine kinase inhibitors (TKIs). Sunitinib showed evidences of activity in a phase I trial in different tumors, including thyroid cancers. TKIs are usually more effective in combination with standard chemotherapy. Among chemotherapeutic drugs, preclinical studies using irinotecan seem to be very promising in different types of thyroid carcinomas. The aim of this study is to determine the activity of sunitinib alone and in combination with irinotecan on endothelial and ATC cells. METHODS: Proliferation and apoptotic assays were performed on human dermal microvascular endothelial cells (HMVEC-d) and ATC (8305C, FB3) cell lines exposed to sunitinib (SU) and SN-38, the active metabolite of irinotecan, for 72h. The synergism was determined with the method by Chou and quantified by the combination index (CI), where CI &amp;lt; 1, CI = 1, and CI &amp;gt; 1 indicates synergism, additive effect, and antagonism, respectively. Cell-based phospho-VEGFR-2 assay was performed and ERK1/2 and Akt phosphorylation were quantified by ELISA kits. Cyclin D1 and CDK2 gene expression were performed with real-time PCR and cyclin D1 intracellular concentrations were measured by ELISA. 8305C xenografts in nude mice were treated with sunitinib (50 mg/kg/day) and tumour volumes were measured. RESULTS: A strong antiproliferative and pro-apoptotic activities were determined by SU on both endothelial and cancer cells, synergistically enhanced by SN38. Phospho-VEGFR-2 levels significantly decreased after SU treatments in activated endothelial cells; ERK1/2 and Akt phosphorylation was significantly inhibited by SU in endothelial and cancer cells, although at lower concentrations in the endothelial ones. Moreover, SU treatment greatly inhibited the expression of the cyclin D1 and CDK2 genes in both endothelial and cancer cells, decreasing the cyclin D1 protein intracellular concentration. In vivo administration of sunitinib was effective and determined a significant tumor regression. CONCLUSIONS: SU demonstrated a highly significant antiproliferative and proapoptotic activity, for activated endothelial and ATC cells. Moreover, the simultaneous combination of sunitinib and irinotecan determined a high synergism on endothelial and ATC cells, suggesting a possible translation of this schedule into the clinics. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4375. doi:1538-7445.AM2012-4375
Breast Cancer Risk Single Nucleotide Polymorphism (SNP) Genotypes Do Not Correlate with Risk Estimates from Existing Prediction Models.
Authors: E. Comen, L. Balistreri, T. Kirchhoff, M. Gaudet, A. Dutra Clark, C. Hudis, K. Offit, M. Robson
Journal: Cancer Research (2009)

Abstract Background:Breast cancer risk assessment professionals employ models to estimate individual probabilities of developing breast cancer. The Gail, Claus and BRCAPro models integrate personal, reproductive and family history variables to generate absolute risk estimates. A number of common DNA variants (single nucleotide polymorphisms, SNPs) are associated with modest elevations (relative risk &amp;lt; 2) of breast cancer risk. We investigated the correlation between genotype at 18 published risk SNPs and model-derived breast cancer risk estimates.Methods:Subjects were 475 unaffected, BRCA mutation-negative women who were evaluated for a family history of breast or ovarian cancer. At the time of testing, subjects provided information that was used to estimate absolute breast cancer risk by Gail, Claus, and BRCAPro models. Subjects were genotyped by Sequenom iPLEX MassArray (Sequenom, Inc., San Diego, CA) at loci reported to be associated with elevations in breast cancer risk (1p11.2, 2q35, 5p12, 6q22.33, 8q24, CASP8, COX11, FGFR2, LSP1, MAP3K1, RAD51L1, SLC4A7, TNRC9). Kruskal-Wallis and Spearman correlation tests were used to compare risk estimates for individuals by genotype and number of risk alleles.Results:The median age at sample donation was 46 years (range 24-83). Most subjects (94.9%) were white, and 65.5% were of Ashkenazi Jewish (AJ) ancestry. Median breast cancer risk scores risk estimates were significantly lower from BRCAPro (5 yr: 1.1%, lifetime (LT): 11.6%) than those derived from Gail (5 yr: 1.8%, LT: 18.5%) or Claus (5 yr: 1.5%, LT: 11.8%) models. No significant differences (p&amp;gt;0.05) in distribution of estimated breast cancer risk scores were found between women carrying 0, 1, or 2 risk alleles at any locus except 6q22.33, where AJ women homozygous for the risk allele rs2180341 were noted to have higher LT Claus (p=0.001) and BRCAPro (p=0.01) estimates. When comparing subjects with no risk alleles to those with 1-2 risk alleles for each SNP, no significant differences in distribution of estimated risk were noted at any loci, including 6q22.33. There was no significant correlation between the total number of risk alleles carried by a subject and her estimated lifetime Gail (ρ=-0.052, P=0.27), Claus (ρ=0.051, P=0.32), or BRCAPro (ρ=0.024, P=0.60) risk.Conclusions:In this analysis, risk allele genotype did not correlate with absolute breast cancer risk estimated by standard models. This suggests that the contribution to risk of genotype at these SNPs is insufficient to impact the modeled estimate. Further studies are necessary to evaluate whether incorporation of genotypic information can improve the calibration or discriminatory accuracy of existing models. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 901.
Acute tubular necrosis after exposure to diesel oil.
Authors: A J Crisp, A K Bhalla, B I Hoffbrand
Journal: BMJ (1979)

definite spontaneous activity but poor relaxation and severe contraction fasci- culation.Twitching was associated with a polyphasic unit of long duration firing about five times a second.Units were prolonged and polyphasic up to 3 mV.The interference pattern was reduced.We concluded that the quadri- ceps weakness was neurogenic and that the pattern of electrophysiological abnormality was consistent with motor neurone disease.Left radical pneumonectomy was performed with good clearance of lymph nodes from the mediastinum.The neoplasm was a large-cell carcinoma with a suspicion of adenocarcinomatous tubules in places.All fasciculation immediately resolved and pain in the knees disappeared.Six months later there was much less wasting of quadriceps and no fasciculation.Right quadriceps and hamstrings were slightly weak but the left leg was normal.Reflexes in the legs were normal and plantar responses flexor.Clubbiing was reduced, and the gynaecomastia had gone.Electromyography of the right vastus medialis and rectus femoris showed no fibrillation or fasciculation and, though the interference pattern was mildly reduced, the motor units looked normal.Some polyphasic units were seen in the right tibialis anterior but they were not prolonged or increased in amplitude.There was no evidence of a lower motor neurone lesion.
Engineering the Growth Factor Microenvironment with Fibronectin Domains to Promote Wound and Bone Tissue Healing
Authors: Mikaël M. Martino, Federico Tortelli, Mayumi Mochizuki, Stephanie Traub, Dror Ben-David, Gisela A. Kuhn, Ralph Müller, Erella Livne, Sabine A. Eming, Jeffrey A. Hubbell
Journal: Science Translational Medicine (2011)

A multifunctional fibronectin fragment enhances the regenerative effects of growth factors in vivo in animal models of chronic wounds and critical-size bone defects.
FDA announces fast track approval of new drug for lung cancer
Authors: O. Dyer
Journal: BMJ (2003)

The US Food and Drug Administration this week approved AstraZeneca's new cancer drug gefitinib (Iressa), the first of a new class of cancer drugs billed as a well tolerated alternative to conventional chemotherapy. But the approval for use in non-small cell lung cancer was conditional on further studies, and the drug will not be prescribed for first line treatment as originally intended.

Gefitinib belongs to a class of drugs known as epidermal growth factor receptors, which block signals in cancer cells that promote growth. It was approved in Japan in July 2002, but the manufacturer's …
Glasses for people who need them could result in economic gain
Authors: R. Dobson
Journal: BMJ (2009)

More than 150 million people worldwide are visually impaired or blind as a result of not having appropriate glasses, according to a report. Uncorrected and undercorrected refractive error is estimated to cost the world economy up to $428bn (£308bn; €333bn) in lost productivity ( Bulletin of the World Health Organisation 2009, doi:10.2471/BLT.08.055673).

It “has a potentially greater impact on the global economy than all other preventable vision disorders,” say the authors.

The authors, who used national population, epidemiological, and economic data, say that the size of this correctable burden has …