Triple Therapy for Hepatitis C Virus Infection in Patients Receiving Hemodialysis
Authors: Chen-Hua Liu, Jia-Horng Kao
Journal: Annals of Internal Medicine (2014)

Letters15 April 2014Triple Therapy for Hepatitis C Virus Infection in Patients Receiving HemodialysisChen-Hua Liu, MD and Jia-Horng Kao, MD, PhDChen-Hua Liu, MDFrom National Taiwan University Hospital, Taipei, Taiwan.Search for more papers by this author and Jia-Horng Kao, MD, PhDFrom National Taiwan University Hospital, Taipei, Taiwan.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5008-4 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Lemoinne and colleagues’ patient had a low probability to achieve sustained virologic response from dual therapy because he was male and had advanced hepatic fibrosis and an unfavorable interleukin-28B genotype. A previous small-scale study reported that telaprevir-based triple therapy had higher sustained virologic response rates than dual therapy in treatment-naive patients with HCV genotype 1 receiving hemodialysis. However, those who received triple therapy had more hematologic toxicity, skin rash, and dysgeusia (1). Data on previously treated patients with HCV infection receiving hemodialysis are limited except for 1 study on those who relapsed after receiving pegylated or standard ...References1. Basu PP, Siriki R, Shah NJ, Farhat S, Mittimanni K, Atluri S, et al. Telaprevir with adjusted dose of ribavirin in naïve CHC-G1: efficacy and treatment in CHC in hemodialysis population. TARGET-C (RCT). J Hepatol. 2013;58:S30-1. CrossrefGoogle Scholar2. Liu CH, Liang CC, Liu CJ, Tsai HB, Hung PH, Hsu SJ, et al. Pegylated interferon alpha-2a plus low-dose ribavirin for the retreatment of dialysis chronic hepatitis C patients who relapsed from prior interferon monotherapy [Letter]. Gut. 2009;58:314-6. CrossrefMedlineGoogle Scholar3. Chou R, Hartung D, Rahman B, Wasson N, Cottrell EB, Fu R. Comparative effectiveness of antiviral treatment for hepatitis C virus infection in adults: a systematic review. Ann Intern Med. 2013;158:114-23. LinkGoogle Scholar4. Liu S, Cipriano LE, Holodniy M, Owens DK, Goldhaber-Fiebert JD. New protease inhibitors for the treatment of chronic hepatitis C: a cost-effectiveness analysis. Ann Intern Med. 2012;156:279-90. [PMID: 22351713] LinkGoogle Scholar5. Cornpropst MT, Denning JM, Clemons D, Marbury TC, Alcorn H, Smith WB, et al. The effect of renal impairment and end stage renal disease on the single dose pharmacokinetics of PSI-7977. J Hepatol. 2012;56:S433. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Chen-Hua Liu, MD; Jia-Horng Kao, MD, PhDAffiliations: From National Taiwan University Hospital, Taipei, Taiwan.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M13-0989. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPegylated Interferon-α2a With or Without Low-Dose Ribavirin for Treatment-Naive Patients With Hepatitis C Virus Genotype 1 Receiving Hemodialysis Chen-Hua Liu , Chung-Feng Huang , Chun-Jen Liu , Chia-Yen Dai , Cheng-Chao Liang , Jee-Fu Huang , Peir-Haur Hung , Hung-Bin Tsai , Meng-Kun Tsai , Shih-I Chen , Jou-Wei Lin , Sheng-Shun Yang , Tung-Hung Su , Hung-Chih Yang , Pei-Jer Chen , Ding-Shinn Chen , Wan-Long Chuang , Ming-Lung Yu , and Jia-Horng Kao Triple Therapy for Hepatitis C Virus Infection in Patients Receiving Hemodialysis Sara Lemoinne , Benoit Barrou , and Dominique Thabut Metrics Cited byEpidemiology update for hepatitis C virus and hepatitis B virus in end-stage renal disease in France 15 April 2014Volume 160, Issue 8Page: 581-582KeywordsDisclosureFibrosisHepatitis C virusInfectious hepatitisPatientsPharmacokineticsProtease inhibitorsRashesSafetyToxicity ePublished: 15 April 2014 Issue Published: 15 April 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...