Observations on Steatorrhea Associated with Gastric Hypersecretion and Pancreatic Islet Cell Neoplasm
Authors: WILLIAM S. HAUBRICH
Journal: Annals of Internal Medicine (1962)

Case Reports1 February 1962Observations on Steatorrhea Associated with Gastric Hypersecretion and Pancreatic Islet Cell NeoplasmWILLIAM S. HAUBRICH, M.D., F. SCOTT O'NEIL, M.D., MELVIN A. BLOCK, M.D.WILLIAM S. HAUBRICH, M.D.Search for more papers by this author, F. SCOTT O'NEIL, M.D.Search for more papers by this author, MELVIN A. BLOCK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-2-302 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOf the reported cases of pancreatic islet cell neoplasm associated with gastric hypersecretion (Zollinger-Ellison syndrome), about one-third include diarrhea as a prominent symptom. Occasionally, nausea, vomiting, and diarrhea are sufficient to induce electrolyte derangement, notably hypokalemia (1-3). In four reports (4-7), the diarrhea was suspected or proved to include steatorrhea. Among seven patients in whom the Zollinger-Ellison syndrome has been recognized at the Henry Ford Hospital, diarrhea has been noted in four, and two of these have exhibited steatorrhea.One of the latter patients, who had neither symptom nor sign of peptic ulcer disease, sought medical care primarily because of...References1. PRIESTALEXANDER WMMK: Islet cell tumors of pancreas with peptic ulceration, diarrhea, and hypokalemia. Lancet 2: 1145, 1957. CrossrefGoogle Scholar2. VERNERMORRISON JVAB: Islet cell tumor, refractory diarrhea, and hypokalemia. Amer. J. Med. 25: 374, 1958. CrossrefMedlineGoogle Scholar3. CHEARSTHOMPSONHUTCHESONPATTERSON WCJEJBCO: Pancreatic islet cell tumor with severe diarrhea. Amer. J. Med. 29: 529, 1960. CrossrefMedlineGoogle Scholar4. MAYNARDPOINT EPWW: Steatorrhea associated with ulcerogenic tumor of pancreas. Amer. J. Med. 25: 456, 1958. CrossrefMedlineGoogle Scholar5. SANCHEZSOMMERS GCSC: Peptic ulcer diathesis with a mixed adenocarcinoma of pancreas. Gastroenterology 38: 467, 1960. CrossrefMedlineGoogle Scholar6. KABLER JD: Rare malabsorption syndromes. Ann. Intern. Med. 52: 1221, 1960. LinkGoogle Scholar7. RAWSONENGLANDGILLANFRENCHSTAMMERS AMGGJMFA: Zollinger-Ellison syndrome with diarrhea and malabsorption. Lancet 2: 131, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, MichiganFrom the Division of Gastroenterology and the Department of General Surgery, Henry Ford Hospital, Detroit 2, Michigan.Requests for reprints should be addressed to William S. Haubrich, M.D., Division of Gastroenterology, Henry Ford Hospital, Detroit 2, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByZollinger-Ellison Syndrome: Clinical Presentation in 261 PatientsDiarrhoea and Digestive Endocrine TumoursZollinger-Ellison SyndromeMagenThe Zollinger-Ellison Syndrome with SteatorrheaMechanisms of Steatorrhea in the Zollinger-Ellison SyndromeROBERT M. VOGEL, M.D., L. DONALD WEINSTEIN, M.D., TEODORO HERSKOVIC, M.D., HOWARD M. SPIRO, M.D., F.A.C.P.Peptic ulceration and enteritisWatery Diarrhea and Hypokalemia Associated with Pancreatic Islet Cell AdenomaDiarrhea and Pancreatic Islet Cell TumorThe Zollinger-Ellison Syndrome. Its Place in the Pathophysiology of Gastric Acid Secretion and of its Hormonal RegulationDiarrhea in a child with a catecholamine-secreting ganglioneuroma 1 February 1962Volume 56, Issue 2Page: 302-307KeywordsDiarrheaDigestive systemNauseaPeptic ulcersSurgeryVomitingZollinger Ellison syndrome Issue Published: 1 February 1962 PDF DownloadLoading ...