tbuckley/cabot-search huggingface dataset:
Health effects of the gas-aerosol complex. Report to Special Committee on Health and Ecological Effects of Increased Coal Utilization.
Authors: B D Goldstein
Journal: Environmental Health Perspectives (1979)

Combustion products derived from the burning of coal are definitely capable of producing adverse human health effects. No single component of the combustion product mixture is solely responsible. Rather, effects are due to a group of compounds, both gases and aerosols, in the effluents of stationary source combustion processes. Although incompletely defined, the individual components of the gas-aerosol complex appear to be capable of interacting both in terms of atmospheric chemistry and health effects. The three primary air quality standards pertinent to regulating coal combustion all represent to some extent indirect, although reasonable, measures of this gas-aerosol complex. As a group, these standards appear to be adequate to protect human health. Conventional toxicological considerations suggest that the adverse health effects of any necessary increase in coal combustion effluents would be greatest per unit of coal in those areas which are most heavily populated and have the highest preexisting levels of the gas-aerosol complex. In order to decrease the degree of uncertainty for future decisions of this type, it is important that prospective epidemiological and air monitoring studies be initiated in conjunction with any large scale introduction of coal use.
ROBERT WILLAN, M.D., F.R.S., F.S.A.
Authors: C. C. BOOTH
Journal: British Journal of Dermatology (1968)

Journal Article ROBERT WILLAN, M.D., F.R.S., F.S.A. Get access C. C. BOOTH C. C. BOOTH Postgraduate Medical School, Du Cane Road, London W.12 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 80, Issue 7, 1 July 1968, Pages 459–468, https://doi.org/10.1111/j.1365-2133.1968.tb11982.x Published: 01 July 1968 Article history Accepted: 18 January 1968 Published: 01 July 1968
The Icatibant Outcome Survey: Observational Data in Patients with Angioedema Due to Acquired C1 Inhibitor (C1-INH) Deficiency
Authors: Hilary Longhurst, Andrea Zanichelli, Teresa Caballero, Laurence Bouillet, Werner Aberer, Vincent Fabien, Marcus Maurer
Journal: Journal of Allergy and Clinical Immunology (2015)
Abstract IA39: Squamous cell lung cancer 2014.
Authors: Peter S. Hammerman
Journal: Clinical Cancer Research (2014)

Abstract Despite the robust progress in developing molecularly targeted therapies for patients with lung adenocarcinoma, patients with other types of lung cancer have not benefitted much to date from molecularly targeted therapy. While in the past this was due to a lack of knowledge of the molecular underpinnings of other lung cancer types, large-scale genomic surveys have now demonstrated that relevant and targetable genomic alterations can be found in all histologies of lung cancer. Here I discuss recent data from genomic analyses of squamous cell lung cancer, the second most common type of non-small cell lung cancer and describe potential therapeutic targets in this disease with an emphasis on Fibroblast Growth Factor Receptors. I will summarize preclinical and early clinical studies and discuss how further progress in targeted therapy for squamous cell carcinomas can be made. Citation Format: Peter S. Hammerman. Squamous cell lung cancer 2014. [abstract]. In: Proceedings of the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer; 2014 Jan 6-9; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2014;20(2Suppl):Abstract nr IA39.
Abstract 3218: Zyflamend, a multi-herbal product, selectively inhibits the growth of triple negative breast cancer cells <i>in vitro</i>
Authors: Angelica M. Gutierrez-Barrera, Banu K. Arun, Peiying Yang, Carrie Cartwright
Journal: Cancer Research (2014)

Abstract Triple negative breast cancer (TNBC), a subpopulation of breast cancer that has a high mortality rate, recently has been shown to be quite diverse with approximately 7 different molecular subtypes. As a result, treatment with an agent that can potentially target multiple pathways might be an effective approach. Zyflamend (Zy), a unique herbal preparation consisting of 10 concentrated herbal extracts, has been shown to suppress the proliferation of various cancer cells including prostate, melanoma, and bladder cancers. However, its role in TNBC has not been investigated. To examine its anticancer activity in TNBC, we utilized a crystal violet staining assay to determine the proliferation of cells, FACS analysis for cell cycle and apoptosis and gene/protein expression analysis to delineate the plausible mechanism of action. Among a number of breast cancer cell lines including MCF-7, SUM149, MDMB231, BT549 and HCC1937, Zy exerted stronger inhibitory effect in all TNBC cells with IC50 values ranging between 400-800μg/ml (0.5-1 μl/ml) whereas MCF-7, an estrogen/progesterone receptor positive cell line, required 1000μg/ml (1.5μl/ml). Similarly, the morphologies of SUM149, MDAMB231, and BT549 cell lines were notably disrupted by Zy treatment (400μg/ml) when these cells were cultured using three dimensional techniques. FACS analysis showed that there was a dramatic shift to subG1 phase, suggesting cells might undergo apoptosis. Reverse Phase Proteomic Array indicated that proteins affecting the cell cycle progression, cell junction regulation, and cell signaling were altered in BT549 and HCC1937 by 24 hr Zy treatment (800μg/ml).. When compared to the vehicle control, gene expression analysis showed that several inflammatory genes were downregulated by at least 50% and these included 5- and 12-lipooxygenase, leukotriene receptors, TNF receptor, and NF-κB in HCC1937 (800μg/ml), MDAMB231(800μg/ml) and SUM149 (400μg/ml) cells. Taken together, our preliminary data suggests that Zy inhibits TNBC proliferation by inhibiting inflammation, regulating cell cycle, and inducing cell death. Further studies are ongoing to evaluate these effects in in vivo triple negative breast cancer models. Citation Format: Angelica M. Gutierrez-Barrera, Banu K. Arun, Peiying Yang, Carrie Cartwright. Zyflamend, a multi-herbal product, selectively inhibits the growth of triple negative breast cancer cells in vitro. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3218. doi:10.1158/1538-7445.AM2014-3218
IMMUNOLOGIC RELATIONS AMONG VARIOUS ANIMAL COLLAGENS
Authors: Sidney Rothbard, Robert F. Watson
Journal: The Journal of Experimental Medicine (1965)

By the use of complement fixation and in vivo immunofluorescence with cross-absorption studies it was shown that acid soluble collagens prepared from rat, mouse, guinea pig, chicken, carp, and man exhibit species specificity. Rat and mouse collagens were found to be indistinguishable and to cross-react with guinea pig collagen. Cross-reactions also occurred between the collagens of rat and man and chicken and man. Tissue specificity, or an antigen common to all of the collagens, was not demonstrated. There was complete agreement in the results of the two immunologic methods. The findings in this study support the conclusion that collagen in some form is present in the renal glomerular basement membranes.
Substitution of Levothyroxine Products
Authors: Sheldon S. Stoffer
Journal: JAMA (1979)

<h3>To the Editor.—</h3> Since calling attention to the problem of generic substitution of levothyroxine products in a recent letter (240:1241, 1978), we recently encountered evidence demonstrating that in one case, a generic product was not equal in potency to the brand name product. A 68-year-old woman who had primary hypothyroidism and a large goiter returned for a routine examination. Instead of receiving the brand name levothyroxine product we prescribed, the pharmacist had switched the prescribed drug to a look-alike generic product. While she was receiving 0.1 mg daily of generic levothyroxine, the patient's free thyroxine index was 1.0 (normal, 1.4 to 4.0), and by radioimmunoassay, the serum thyroid-stimulating hormone level was 76.0 μunits/mL (normal, less than 10). The drug regimen was changed to 0.1 mg daily of the brand name levothyroxine product, and seven weeks later, the free thyroxine index was 2.1, and the serum thyroidstimulating hormone level was 8.6
The Effects of Azathioprine (Imuran) on Purine Synthesis in Clinical Disorders of Purine Metabolism*
Authors: William N. Kelley, Frederick M. Rosenbloom, J. Edwin Seegmiller
Journal: Journal of Clinical Investigation (1967)

Azathioprine, a purine analogue, significantly suppressed the purine synthesis de novo of two gouty patients manifesting overproduction of uric acid, as well as three of four gouty patients who showed normal uric acid production. This suppression is taken as evidence that phosphoribosyl-pyrophosphate amidotransferase, the rate-controlling step in purine synthesis de novo, has a normal sensitivity to feedback inhibitors in the patients who responded to the drug.
HOST-PARASITE FACTORS IN GROUP A STREPTOCOCCAL INFECTIONS
Authors: Natalie Cremer, Dennis W. Watson
Journal: The Journal of Experimental Medicine (1960)

THE DATA PRESENTED IN THIS STUDY SUGGEST THAT GROUP A STREPTOCOCCI PRODUCE TWO DISTINCT PYROGENIC TOXINS: one primarily an intracellular toxin and the other mainly an extracellular toxin. Both of these toxins are not extractable by the conventional methods, phenol and TCA, used for isolation of Gram-negative bacterial endotoxin. Their chemical composition, therefore, differs from that of Gram-negative bacterial endotoxin. On the basis of tolerance studies it appears that similar non-specific host factors may be involved in the detoxification of both the streptococcal intracellular pyrogenic toxin and the Gram-negative bacterial endotoxin. Detoxification of streptococcal exotoxin requires a more immunologically specific mechanism. Because all the Group A sonic extracts studied elicited reciprocal tolerance to one another, it is suggested that tolerance to the intracellular pyrogenic toxin is not correlated with type-specificity.
Intracellular alkalinization induced by bradykinin sustains activation of the constitutive nitric oxide synthase in endothelial cells.
Authors: I Fleming, M Hecker, R Busse
Journal: Circulation Research (1994)

The transient increase in [Ca2+]i in endothelial cells after stimulation with bradykinin can account for the initiation but not the sustained production of nitric oxide (NO). Therefore, we investigated whether this sustained activation of the constitutive NO synthase (cNOS) could be mediated by an increase in pHi, which is induced by an activation of the Na(+)-H+ exchanger rather than an increase in [Ca2+]i. Cultured human endothelial cells grown on coverslips were loaded with either C.SNAFL-2 or fura 2-AM for fluorometric analysis of either pHi or [Ca2+]i. NO release was assayed by the ability of effluent from endothelial cells to stimulate purified soluble guanylyl cyclase. The pH dependence of a microsomal cNOS preparation was determined by assay of L-[3H]citrulline formation from L-[3H]arginine. Bradykinin (10 nmol/L) induced a biphasic change in endothelial pHi consisting of an initial acidification followed by a prolonged alkalinization above resting values. Inhibition of the Na(+)-H+ exchanger using HOE 694 (10 mumol/L) prevented this increase in pHi. The L-citrulline assay revealed a twofold increase in cNOS activity on increasing pH from 6.7 to 7.4, an optimum at pH 7.5, and a complete abolition of activity at pH 8.6. Endothelial production of NO 15 minutes after starting the infusion of bradykinin was maintained at significantly higher levels in control cells compared with cells pretreated with HOE 694. The latter effect cannot be accounted for by an increase in intracellular Ca2+, since [Ca2+]i levels were not significantly different between the two groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Diarrhea Associated With Thyroid Medication
Authors: Robert C. Rendtorff
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Dr. William B. Parsons, Jr., gave a concise and scholarly answer to the question posed inThe Journal(<b>204</b>:185, 1968). This had to do with causes of diarrhea associated with thyroid medication. Another possibility to explain the persistence of diarrhea which is related to the medication and which appears to be relatively new was not mentioned. This is that thyroid preparations and other similar animal products used in human medicine have been found contaminated with various species of<i>Salmonella</i>. It was not stated whether this patient, with the diarrhea, had bacteriological examinations of stools. Findings of<i>Salmonella</i>contamination in commercially available food and drug products including hormonal and enzymatic preparations used in medicine indicate a continuing need for bacteriologic studies of stools in cases of diarrhea.
La macrodilatation du sphincter d'Oddi après sphinctérotomie permet d'extraire les gros calculs et empierrements cholédociens sans lithotritie mécanique
Authors: L Poincloux, O Rouquette, J Privat, A Abergel, G Bommelaer
Journal: Endoscopy (2010)

But: L'objectif de ce travail était d'évaluer la faisabilité, l'efficacité et la morbidité de la macrodilatation au ballonnet du sphincter d'Oddi après sphinctérotomie pour l'extraction des gros calculs et empierrements cholédociens et d'évaluer rétrospectivement le taux de lithotritie mécanique évité dans un centre expert réalisant 500 CPRE annuelles.
The effect of nonuniform magnetic targeting of intracoronary-delivering mesenchymal stem cells on coronary embolisation
Authors: Zheyong Huang, Yunli Shen, Ning Pei, Aijun Sun, Jianfeng Xu, Yanan Song, Gangyong Huang, Xiaoning Sun, Shuning Zhang, Qing Qin, Hongming Zhu, Shan Yang, Xiangdong Yang, Yunzeng Zou, Juying Qian, Junbo Ge
Journal: Biomaterials (2013)
Gene therapy for type 1 diabetes: a novel approach for targeted treatment of autoimmunity
Authors: Rémi J. Creusot, C. Garrison Fathman
Journal: Journal of Clinical Investigation (2004)

It has been difficult to develop therapies that target those T cells initiating and mediating the pathogenesis of autoimmune disease. Indeed, most current treatments indiscriminately affect both the autoreactive T cells and the "good" T cells, putting the patient at risk of compromised immune function. A new approach raises the possibility of targeted therapy for autoimmunity. Transplantation of hematopoietic stem cells modified to express a protective form of MHC class II corrects a defect in central tolerance. This method contrasts with other targeted therapies that attempt to modify peripheral tolerance, which is also defective in type 1 diabetes mellitus.
DIABETES MELLITUS.REPORT ON A CASE, INCLUDING A NEW METHOD OF PROGNOSIS.
Authors: ARTHUR R. MANDEL
Journal: JAMA (1904)

A diabetic patient with a low acidosis and with no trace of albumin in the urine, when put on a meat fat diet, showed a constant ratio of dextrose to nitrogen in the urine. The ratio was Dextrose: Nitrogen=3.65:1, and is the same as that found in dogs made diabetic with phlorhizin. This ratio was uninfluenced by fat digestion or by fat metabolism. The sugar was, therefore, derived from proteid alone, and rose and fell with the proteid metabolism as indicated by the amount of urinary nitrogen. The patient died five weeks later. There was apparently a complete intolerance for carbohydrates.; 85 per cent. of starch and 80 per cent. of levulose fed were excreted as sugar in the urine. Withdrawal of the carbohydrates from the diet and the continuance of the same proteid-fat quantity in the food had no effect on the excretion of nitrogen in
Growth of Harvey's Ideas on the Circulation of the Blood
Authors: G. Whitteridge
Journal: BMJ (1966)

MEDICAL JOUMRNLwhich serves as an introduction to De motu cordis: " On several earlier occasions in my anatomical lectures, I revealed my new concept of the heart's movement and function of the blood's passage round the body."As a direct consequence of Sieveking's enthusiasm, a com- mittee was set up by the Royal College of Physicians, and in 1886
Visceral larva migrans caused by Trichuris vulpis presenting as a pulmonary mass.
Authors: Y Masuda, T Kishimoto, H Ito, M Tsuji
Journal: Thorax (1987)

<h3>Abstract</h3> <h3>Background</h3> The 2019 novel coronavirus infected pneumonia (COVID-19) represents a significant public health threat. The COVID-19 emerged in December 2009 in Wuhan, China and rapidly spread to other regions and countries. The variation in transmission patterns and disease spread in regard to time or among different locations, partially reflecting the public health intervention effects, remains to be quantified. As most transmissibility-related epidemic parameters are unknown, we sought, with minimal assumptions, to estimate real-time transmissibility and forecast new cases using dynamic modelling. <h3>Methods</h3> Using the cases reported from the National Health Commission of China and transportation data, including the total number of travelling hours through railway, airplane, and car outbound from Wuhan, we have built a time-series model to estimate real-time underlying transmission rates of newly generated cases sequentially from January 20, 2020 to Feb 13, 2020 in Wuhan, Hubei province and other 28 provinces in China. We quantified the instantaneous transmission rate and relative reproduction number (<i>R</i><sub><i>t</i></sub>) of COVID-19, and evaluated whether public health intervention affected the case transmissibility in each province. Based on the current estimates, we have predicted the trend of disease spread with a high level of certainty. <h3>Findings</h3> We estimated that <i>R</i><sub><i>t</i></sub> declined from the range of 4 to 5 towards 1 and remained below unity, while there was an initial growth followed by a decline in a shorter period in Hubei and other provinces. The ratio of transmission rates decreased dramatically from January 23 to 27 likely due to the rigorous public health intervention implemented by the government beginning on January 23, 2020. The mean duration of the infectious period was 6 to 9 days. We have predicted the trend of infection sizes which became stable in provinces around February 19 to 24, 2020, and the date of containment would be one-week later in Wuhan. <h3>Interpretation</h3> Public health interventions implemented at both the social and personal levels are effective in preventing outbreaks of COVID-19 in Wuhan and other provinces. Model prediction results suggested that COVID-19 will be contained around the end of February 2020 in China.
The treatment of Darier's disease with topical tazarotene
Authors: None Oster-Schmidt
Journal: British Journal of Dermatology (1999)

Journal Article The treatment of Darier's disease with topical tazarotene Get access C. Oster‐Schmidt C. Oster‐Schmidt Weyerdamm 5, 57610 Altenkirchen, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 141, Issue 3, 1 September 1999, Pages 603–604, https://doi.org/10.1046/j.1365-2133.1999.03089.x Published: 01 September 1999
Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia
Authors: Pamela S. Becker, Kenneth J. Kopecky, Adrianne N. Wilks, Sylvia Chien, John M. Harlan, Cheryl L. Willman, Stephen H. Petersdorf, Derek L. Stirewalt, Thalia Papayannopoulou, Frederick R. Appelbaum
Journal: Blood (2008)
Downregulation of lipopolysaccharide response in drosophila by negative crosstalk between the AP1 and NF-κB signaling modules
Authors: Taeil Kim, Joonsun Yoon, Hwansung Cho, Wook-bin Lee, Joon Kim, Young-Hwa Song, Se Nyun Kim, Jeong Ho Yoon, Jeongsil Kim-Ha, Young-Joon Kim
Journal: Nature Immunology (2005)
Sulfonal in the Vomiting of Pregnancy.
Authors: S. E. Burroughs
Journal: JAMA (1895)

Allison, Iowa, <h3>To the Editor:</h3> —I have found this medicine a sure relief for this most obstinate trouble. I have been using it over a year, have recommended it to neighboring physicians and never knew it to fail. Those who have tried it say it works like magic. It will relieve hiccough as effectually as well. My method of giving is 10 to 15 grains (60 to 1), dissolved in two tablespoonfuls boiling water, and given as hot as the patient can bear it. Sulfonal will stop vomiting of most any character, the quickest, safest and surest of any remedy n the category of medicine. I believe every physician hould know this and hope theJournalwill pass it around.
BMA agrees to support legislation to abolish purchaser-provider split
Authors: J. Wise
Journal: BMJ (2015)

The BMA’s governing council has unanimously agreed to support any future legislation that would abolish the split between purchasers and providers of NHS services, the internal and external market, and competition.

A working group examined two sets of legislative proposals on the NHS that were set out in private members’ bills before parliament was dissolved. These were the NHS Amended Duties and Powers Bill and the NHS Reinstatement Bill, subsequently presented in the House of Commons as the NHS Bill 2015 by the Green MP …
Simvastatin-induced effects on bronchial epithelial cells from COPD donors
Authors: Lena Uller
Journal: European Respiratory Journal (2013)

To the Editor: 

I read with interest the report by Lee et al . [1] on inhibition by simvastatin of double-stranded (ds)RNA-induced bronchial epithelial cell production of RANTES, with supportive in vivo data in mice. dsRNA is an interesting challenge agent. It not only mimics viral infection, as noted by Lee et al . [1], but may also reflect effects of released mRNA or secondary structure from necrotic cells that commonly occur in severe bronchial diseases (for references, see [2]). RANTES, similar to interferon (IFN)-β, is induced by activation of the transcription factor IRF3 (IFN regulatory factor 3) [3]. Hence, the anti-RANTES effect demonstrated by Lee et al . [1] may agree with our current demonstration of simvastatin-induced inhibition of IRF3 phosphorylation in dsRNA-challenged bronchial epithelial cells; we used primary cells obtained by bronchial brushings in chronic obstructive pulmonary disease (COPD) patients [4]. We further showed that the inhibition of IRF3 activation occurred without effects on nuclear factor (NF)-κB. As expected …
Observations on Rationing in Tuberculosis
Authors: R. Y. Keers
Journal: BMJ (1948)

J 2OURN45 to physiological development, and many children ceased to get supplements at the phase of development when extra food was most needed.Assessing the Nutrition of the Individual Child In Europe this problem is not so much that of distinguish- ing optimum nutrition at one end of the scale or manifest deficiency disease at the other, but in deciding where the child should be placed in the wide region of suboptimal nutrition which divides the two.Innumerab!e formulae
Prosthetic Mucosal Hypertrophy in the Mouth, Simulating Malignancy
Authors: J. Walter
Journal: BMJ (1953)

The lessons that might be learnt from these observations are: (1) Antibiotics, though of immense value in the treatment of acute infection, especially the localiza- tidn of the disease in the breast, have their limitations.(2) The treatment of a localized collection of pus is still by surgical drainage, the timing of which is now as important as ever.My thanks are due to Mr. Maurice R. Ewing for encourage- rnent and help in the preparation of this paper.