tbuckley/cabot-search huggingface dataset:
Predictors of Community Therapists’ Use of Therapy Techniques in a Large Public Mental Health System
Authors: Rinad S. Beidas, Steven Marcus, Gregory A. Aarons, Kimberly E. Hoagwood, Sonja Schoenwald, Arthur C. Evans, Matthew O. Hurford, Trevor Hadley, Frances K. Barg, Lucia M. Walsh, Danielle R. Adams, David S. Mandell
Journal: JAMA Pediatrics (2015)

<h3>Importance</h3> Few studies have examined the effects of individual and organizational characteristics on the use of evidence-based practices in mental health care. Improved understanding of these factors could guide future implementation efforts to ensure effective adoption, implementation, and sustainment of evidence-based practices. <h3>Objective</h3> To estimate the relative contribution of individual and organizational factors on therapist self-reported use of cognitive-behavioral, family, and psychodynamic therapy techniques within the context of a large-scale effort to increase use of evidence-based practices in an urban public mental health system serving youth and families. <h3>Design, Setting, and Participants</h3> In this observational, cross-sectional study of 23 organizations, data were collected from March 1 through July 25, 2013. We used purposive sampling to recruit the 29 largest child-serving agencies, which together serve approximately 80% of youth receiving publically funded mental health care. The final sample included 19 agencies with 23 sites, 130 therapists, 36 supervisors, and 22 executive administrators. <h3>Main Outcomes and Measures</h3> Therapist self-reported use of cognitive-behavioral, family, and psychodynamic therapy techniques, as measured by the Therapist Procedures Checklist–Family Revised. <h3>Results</h3> Individual factors accounted for the following percentages of the overall variation: cognitive-behavioral therapy techniques, 16%; family therapy techniques, 7%; and psychodynamic therapy techniques, 20%. Organizational factors accounted for the following percentages of the overall variation: cognitive-behavioral therapy techniques, 23%; family therapy techniques, 19%; and psychodynamic therapy techniques, 7%. Older therapists and therapists with more open attitudes were more likely to endorse use of cognitive-behavioral therapy techniques, as were those in organizations that had spent fewer years participating in evidence-based practice initiatives, had more resistant cultures, and had more functional climates. Women were more likely to endorse use of family therapy techniques, as were those in organizations employing more fee-for-service staff and with more stressful climates. Therapists with more divergent attitudes and less knowledge about evidence-based practices were more likely to use psychodynamic therapy techniques. <h3>Conclusions and Relevance</h3> This study suggests that individual and organizational factors are important in explaining therapist behavior and use of evidence-based practices, but the relative importance varies by therapeutic technique.
Congenital Malformations of the Heart and the Great Vessels
Authors: Piero Mustacchi
Journal: JAMA (1963)

WHEN epidemiologic consideration is given to the problem of congenital malformations of the heart and great vessels, 3 basic questions arise: (1) how significant is the problem in a community? (2) what is the probability of being born with a cardiovascular defect? and (3) to what extent is life expectancy modified by the presence of a congenital cardiovascular defect? The first question can be answered by an enumeration of all known cases expressed as a prevalence rate; the second by calculating the incidence of defects at birth; and the third by establishing a life table. Answers to all 3 questions have been obtained for the City and County of San Francisco and are set down in this report. The data came from 3 major sources: the San Francisco cardiac registry, the city's vital statistics, and estimates of population migration. <h3>Cardiac Registry and Calculation of Prevalence Rate</h3> Since 1946, the names
Some Requirements in Equipment and Technics for Vectorcardiography
Authors: JAMES A. CRONVICH, GEORGE E. BURCH, J. A. ABILDSKOV
Journal: Circulation (1953)

To reduce the effects of extraneous potentials caused by muscle tremor, sweating, and interference from power circuits, it is desirable to restrict the frequency range of the cathode ray vectorcardiograph. Mathematical analysis of idealized waves and experiments with a photoelectric electrocardiographic generator indicate that a frequency range between the half-power frequency of 0.8 to 80 cycles per second is satisfactory for proper reproduction of most vectorcardiograms. Many investigators construct the vectorcardiogram graphically from the electrocardiogram. In this study it is shown that, unless simultaneous electrocardiograms recorded at greater than usual paper speed are used, such vectorcardiograms may be incorrect.
IMPACT OF MORPHINE ADMINISTRATION ON TICAGRELOR-INDUCED PLATELET INHIBITION IN ST-ELEVATION MYOCARDIAL INFARCTION PATIENTS TREATED BY PRIMARY PCI: RESULTS FROM THE PRIVATE-ATLANTIC STUDY
Authors: Johanne Silvain, Robert Storey, Guillaume Cayla, Jean-Baptiste Esteve, Jean-Guillaume Dillinger, Eric Vicaut, Jean-Philippe Collet, Anne Tsatsaris, Muriel Licour, Néjoua Salhi, Frédéric Lapostolle, Jens Lassen, Christian Hamm, Arnoud Van't Hof, Gilles Montalescot
Journal: Journal of the American College of Cardiology (2015)
Regulation of Hepatic Energy Metabolism and Gluconeogenesis by BAD
Authors: Alfredo Giménez-Cassina, Luisa Garcia-Haro, Cheol Soo Choi, Mayowa A. Osundiji, Elizabeth A. Lane, Hu Huang, Muhammed A. Yildirim, Benjamin Szlyk, Jill K. Fisher, Klaudia Polak, Elaura Patton, Jessica Wiwczar, Marina Godes, Dae Ho Lee, Kirsten Robertson, Sheene Kim, Ameya Kulkarni, Alberto Distefano, Varman Samuel, Gary Cline, Young-Bum Kim, Gerald I. Shulman, Nika N. Danial
Journal: Cell Metabolism (2014)
Old men at play
Authors: C. Douglas
Journal: BMJ (1997)

Grapes of the <i>Vitis vinifera</i> L. varieties `Verigo9 and `Mavro9 were kept in very good marketable condition for 3.5 months at 1-2°C and 85% relative humidity (RH) when fumigated with S0<sub>2</sub> at initial concentrations of 1, 0.5, or 0.25% followed by weekly fumigations with 0.25%. Potassium metabisulfire reduced decay of Sultanina and Rozaki grapes for 5 days at shelf, after their removal from a 12-day cold storage at 0°C and 85% RH. Benomyl and TBZ sprays at 400 ppm active ingredient applied 1, 2, or 3 weeks before harvest reduced decay of Sultanina grapes under shelf life, following 12 days at 1-2°C and 85% RH.
Few glitches are reported as US insurance exchanges open for second enrollment period
Authors: M. McCarthy
Journal: BMJ (2014)

The US health insurance exchanges created by the Affordable Care Act opened at the weekend for the second open enrollment period. By most reports this went much more smoothly than last year’s launch, in which the federal and some state exchange websites were plagued by months of computer glitches and crashes.

Speaking on the Sunday NBC News show Meet the Press Sylvia Mathews Burwell, US …
Abstract 4492: Blockade of angiopoietin-2 or Tie2 is equally effective at inhibiting tumor growth and reducing tumor vessel density in most human tumor xenograft models
Authors: Alexander P. Adler, Christopher Daly, Asma A. Parveen, Thomas Nevins, Jing Shan, Jeanette Fairhurst, Tammy Huang, Joel Martin, Nicholas Papadopoulos, George D. Yancopoulos, Gavin Thurston, Gavin Thurston, Alexandra Eichten
Journal: Cancer Research (2014)

Abstract Angiopoietin-1 (Ang1) and -2 (Ang2) regulate angiogenesis via the endothelial cell-specific receptor tyrosine kinase Tie2. Blocking Ang2 binding to Tie2 decreases vessel density and inhibits tumor growth in various human xenograft models. However, not all tumors respond to Ang2 blockade, which could be due to high Ang1 levels acting as another ligand for Tie2, to Ang2 activities independent of Tie2, or to a weak role for Ang-2/Tie2 signaling in these tumors. To elucidate if Ang1 plays an integral role in tumor angiogenesis and growth, we compared the effects of blocking Ang2 or Tie2 in various tumor xenografts with differing levels of Ang1 expression. We found that in six out of seven tumor models, antibodies that specifically bind Ang2 (REGN910, 10 mg/kg 2x/wk) or that bind Tie2 and block binding of both Ang1 and Ang2 (REGN1376, 10 mg/kg 2x/wk) were equally efficacious at inhibiting tumor growth and decreasing vessel density. In only one tumor model (Calu-6), blockade of Tie2 with REGN1376 was more effective than blockade of Ang2 (REGN910) at reducing tumor growth and decreasing tumor vessel density. Although Calu-6 tumors express high Ang1 levels, other tumors tested (Lox, LS174T) have comparable or higher Ang1 levels and respond similarly to Ang2 and Tie2 blockade, thus the levels of Ang1 do not account for the differential response of Calu-6 tumors. Taken together, our data suggest that Ang2 is the dominant ligand for Tie2 in the microenvironment of most tumors, and further, that the effects of Ang2 are mediated primarily via Tie2. These findings support the approach to specifically block the binding of Ang2 to Tie2 as an anti-angiogenic therapy. Citation Format: Alexander P. Adler, Christopher Daly, Asma A. Parveen, Thomas Nevins, Jing Shan, Jeanette Fairhurst, Tammy Huang, Joel Martin, Nicholas Papadopoulos, George D. Yancopoulos, Gavin Thurston, Gavin Thurston, Alexandra Eichten. Blockade of angiopoietin-2 or Tie2 is equally effective at inhibiting tumor growth and reducing tumor vessel density in most human tumor xenograft models. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4492. doi:10.1158/1538-7445.AM2014-4492
Treating obesity in children.
Authors: C. A. Eriksen, B. A. Ujam
Journal: BMJ (1992)

side of the bed, insertion of a percutaneous endoscopic gastrostomy tube will not necessarily prevent this as these tubes may themselves be pulled out by a determined patient-indeed, some authorities believe that psychosis and dementia are relative contraindications to insertion.8Thus percutaneous endoscopic gastrostomy is not the end of the line for nasogastric feeding but an example of one of several useful techniques that may be considered for long term enteral feeding.Nasoenteral tubes will continue to provide the main route of access for most patients requiring enteral nutrition.
Alkalinization of Urine
Authors: Robert H. Davis
Journal: JAMA (1975)

To the Editor.—  In the article entitled Renal Geology (231:865) it was stated that alkalinization of the urine with sodium bicarbonate may sometimes be difficult and that the use of acetazolamide may be helpful in producing this effect. I was surprised by this recommendation since it is known that acetazolamide may itself produce renal calculi.  What is the incidence of acetazolamide-produced renal calculi and what is their composition? As an ophthalmologist who uses acetazolamide, I would also appreciate knowing what measures the ophthalmologist should take to reduce the potential for renal calculus formation in a patient who is using this medication.
ON SOME DIFFICULTIES IN REFERENCE TO THE EARLY SURGICAL TREATMENT OF APPENDICITIS.
Authors: CARL BECK
Journal: JAMA (1895)

Although discussions upon appendicitis have been quite numerous lately, I hope there is no need to apologize for bringing this subject up again. In view of the immense importance and the great interest which attach to this disease, and also of the<i>many points still entirely obscure and unsettled</i>in connection with it, and last, but not least, the continued existence of so many skeptics as to the prevalence of the affection as well as to the importance of its surgical treatment, it can not at present be discussed too frequently. While it is true, that the surgical technique of the operation for appendicitis has reached, especially through the efforts of surgeons of this country, a state of perfection hardly to be excelled, it is to be regretted on the other hand that, as to the affection itself, particularly as to its etiology, diagnosis and prognosis, a vast number of
B cell-activating Factor of the TNF Family (BAFF) and a Proliferation-inducing Ligand (APRIL) Expression in Chronic Rhinosinusitis
Authors: R SCHLEIMER, A KATO, A PETERS, L SUH, R CARTER, K HARRIS, D CONLEY, L GRAMMER, R KERN
Journal: Journal of Allergy and Clinical Immunology (2008)
THE LEAGUE OF REMEMBRANCE
Authors: W. A. Lane, A. Sloggett, R. Hill, J. Purves-Stewart, A. Fripp, J. Skevington, R. Jones, F. Colyer, A. J. Rice-Oxley, H. J. F. Simson, J. Murray, C. Knox-Shaw, R. H. J. Swan, H. Smale, L. Paton, M. Vaughan
Journal: BMJ (1924)
Toxic Dermatitis Associated with Prednisone Therapy
Authors: Charles D. Bonner, Freddy Homburger
Journal: New England Journal of Medicine (1957)

IT is a puzzling feature of the pharmacology of antiallergic drugs that drug reactions occasionally occur in response to the very substances that are supposed to suppress that type of reaction in the organism. The present case report illustrates this phenomenon, and the conclusion is inescapable that in this patient a generalized erythematous dermatitis of bullous type occurred as a result of the administration of prednisone.Case ReportA 58-year-old man was first seen by us in 1952, having been under treatment for several years for atopic dermatitis involving the face (Fig. 1), neck, hands and wrists, as well as . . .
From the Health Care Financing Administration
Authors: Bruce C. Vladeck
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High-throughput identification of antigen-specific TCRs by TCR gene capture
Authors: Carsten Linnemann, Bianca Heemskerk, Pia Kvistborg, Roelof J C Kluin, Dmitriy A Bolotin, Xiaojing Chen, Kaspar Bresser, Marja Nieuwland, Remko Schotte, Samira Michels, Raquel Gomez-Eerland, Lorenz Jahn, Pleun Hombrink, Nicolas Legrand, Chengyi Jenny Shu, Ilgar Z Mamedov, Arno Velds, Christian U Blank, John B A G Haanen, Maria A Turchaninova, Ron M Kerkhoven, Hergen Spits, Sine Reker Hadrup, Mirjam H M Heemskerk, Thomas Blankenstein, Dmitriy M Chudakov, Gavin M Bendle, Ton N M Schumacher
Journal: Nature Medicine (2013)
Incremental Value of Thallium-201 Imaging
Authors: Monty M. Bodenheimer
Journal: Annals of Internal Medicine (1995)

Letters1 June 1995Incremental Value of Thallium-201 ImagingMonty M. BodenheimerMonty M. BodenheimerSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-11-199506010-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In a patient with a chest pain syndrome, the sine qua non of decision making is an accurate determination of whether coronary artery disease is present and, if so, whether medical therapy or revascularization will yield the best outcome. I have previously argued that noninvasive testing has significant limitations [1]. However, I question whether the study by Christian and colleagues [2] helps clarify the role of exercise thallium stress testing or makes throwing out the baby with the bath water acceptable. I suspect that referral bias explains their findings. In their study, most patients who had an ...References1. Bodenheimer MM. Risk stratification in coronary disease: a contrary viewpoint. Ann Intern Med. 1992; 116:927-36. Google Scholar2. Christian TF, Miller TD, Bailey KR, Gibbons RJ. Exercise tomographic thallium-201 imaging in patients with severe coronary artery disease and normal electrocardiograms. Ann Intern Med. 1994; 121:825-32. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1995Volume 122, Issue 11Page: 881-883KeywordsCatheterizationDecision makingExerciseExercise therapyIschemiaPatientsProspective studiesRevascularizationStable coronary artery diseaseThallium ePublished: 15 August 2000 Issue Published: 1 June 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Which high-risk HPV assays fulfil criteria for use in primary cervical cancer screening?
Authors: M. Arbyn, P.J.F. Snijders, C.J.L.M. Meijer, J. Berkhof, K. Cuschieri, B.J. Kocjan, M. Poljak
Journal: Clinical Microbiology and Infection (2015)

Several countries are in the process of switching to high-risk human papillomavirus (hrHPV) testing for cervical cancer screening. Given the multitude of available tests, validated assays which assure high-quality screening need to be identified. A systematic review was conducted to answer the question which hrHPV tests fulfil the criteria defined by an international expert team in 2009, based on reproducibility and relative sensitivity and specificity compared to Hybrid Capture-2 or GP5+/6+ PCR-enzyme immunoassay. These latter two hrHPV DNA assays were validated in large randomized trials and cohorts with a follow-up duration of 8 years or more. Eligible studies citing the 2009 guideline were retrieved from Scopus (http://www.scopus.com) and from a meta-analysis assessing the relative accuracy of new hrHPV assays versus the standard comparator tests to detect high-grade cervical intraepithelial neoplasia or cancer in primary screening. The cobas 4800 HPV test and Abbott RealTime High Risk HPV test were consistently validated in two and three studies, respectively, whereas the PapilloCheck HPV-screening test, BD Onclarity HPV assay and the HPV-Risk assay were validated each in one study. Other tests which partially fulfil the 2009 guidelines are the following: Cervista HPV HR Test, GP5+/6+ PCR-LMNX, an in-house E6/E7 RT quantitative PCR and MALDI-TOF (matrix-assisted laser desorption-ionization time-of-flight). The APTIMA HPV assay targeting E6/E7 mRNA of hrHPV was also fully validated. However, the cross-sectional equivalency criteria of the 2009 guidelines were set up for HPV DNA assays. Demonstration of a low risk of CIN3+ after a negative APTIMA test over a longer period is awaited to inform us about its utility in cervical cancer screening at 5-year or longer intervals.
BMI and Risk of Serious Upper Body Injury Following Motor Vehicle Crashes: Concordance of Real-World and Computer-Simulated Observations
Authors: Shankuan Zhu, Jong-Eun Kim, Xiaoguang Ma, Alan Shih, Purushottam W. Laud, Frank Pintar, Wei Shen, Steven B. Heymsfield, David B. Allison
Journal: PLoS Medicine (2010)

Men tend to have more upper body mass and fat than women, a physical characteristic that may predispose them to severe motor vehicle crash (MVC) injuries, particularly in certain body regions. This study examined MVC-related regional body injury and its association with the presence of driver obesity using both real-world data and computer crash simulation.Real-world data were from the 2001 to 2005 National Automotive Sampling System Crashworthiness Data System. A total of 10,941 drivers who were aged 18 years or older involved in frontal collision crashes were eligible for the study. Sex-specific logistic regression models were developed to analyze the associations between MVC injury and the presence of driver obesity. In order to confirm the findings from real-world data, computer models of obese subjects were constructed and crash simulations were performed. According to real-world data, obese men had a substantially higher risk of injury, especially serious injury, to the upper body regions including head, face, thorax, and spine than normal weight men (all p<0.05). A U-shaped relation was found between body mass index (BMI) and serious injury in the abdominal region for both men and women (p<0.05 for both BMI and BMI(2)). In the high-BMI range, men were more likely to be seriously injured than were women for all body regions except the extremities and abdominal region (all p<0.05 for interaction between BMI and sex). The findings from the computer simulation were generally consistent with the real-world results in the present study.Obese men endured a much higher risk of injury to upper body regions during MVCs. This higher risk may be attributed to differences in body shape, fat distribution, and center of gravity between obese and normal-weight subjects, and between men and women. Please see later in the article for the Editors' Summary.
From Shrinking Violet to English Rose
Authors: William H. Crosby
Journal: JAMA (1979)

During its era of some 33 years, chemotherapy has greatly prolonged the lives of patients with Hodgkin's disease and may even cure it, but among its ravaging side effects, unbeknown to us until now, is the destruction of sexuality. It has been recognized that some alkylating agents administered year after year in chronic leukemia (busulfan, chlorambucil) may eventually cause sterility in men. But we were unaware that the pulses of drugs used in Hodgkin's disease destroyed libido, ruining personal relations and disrupting families—this in addition to causing sterility. An unbelievable amount of human misery has been silently borne by the patients of three decades. Several years ago when Ramona M. Chapman, MD, had completed her fellowship at Scripps Clinic, she sought and was granted additional research experience at St Bartholomew's Hospital in London. She hoped to continue her studies of breast cancer, intending to investigate, among other matters, the changes
Spontaneous remission and relapse in adult T cell lymphoma/leukaemia associated with HTLV-I.
Authors: C Mattock, N A Anderson, C D Sheldon, M H Rustin, B I Hoffbrand
Journal: BMJ (1986)

evening).Blood pressure was monitored throughout, and he was instructed to report any adverse effects.Concentrations of ab ne were deterniined in duplicate by enzyme immunassay (EMIT, Sy, Palo Alto) six hours after each morning dose.Over the next 48 hours he complained ofdizziness; nausea, ataxia, and diplopia, consistent with carbamaze ie uo icity.Plasma carbemaze- pine concentrations showed-a concurrent rist to a peak of 21 mg/l, 40% higher than baseline values (figure).Stopping diltiazem was associated with a cor- responding decrease in carbamazepine concentrations to previous values.The neurotoxic symptoms rapidly resolved.Blood pressure remained unaltered during treatment..