tbuckley/cabot-search huggingface dataset:
Disappearance of uraemic pruritus after lowering dialysate magnesium concentration.
Authors: H Graf, J Kovarik, H K Stummvoll, A Wolf
Journal: BMJ (1979)

who developed thrombocytopenia and in whom a lymphocyte trans- formation test to gold in vitro was positive.Probably a direct toxic mechanism was responsible for at least some of the adverse reactions to Myocrisin.
<i>Natura non facit saltum</i>: The need for the full continuum of mental representations
Authors: Robert M. French
Journal: Behavioral and Brain Sciences (2002)

Natura non facit saltum (Nature does not make leaps) was the lovely aphorism on which Darwin based his work on evolution. It applies as much to the formation of mental representations as to the formation of species, and therein lies our major disagreement with the SOC model proposed by Perruchet &amp; Vinter.
Idiopathic recurrent superficial thrombophlebitis: treatment with fibrinolytic enhancement.
Authors: P E Jarrett, M Morland, N L Browse
Journal: BMJ (1977)

Sixteen patients with idiopathic recurrent superficial thrombophlebitis were shown to have a defect of blood and tissue fibrinolytic activity. After six months' treatment with stanozolol their mean dilute blood clot lysis time and plasma fibrinogen fell significantly and the mean fibrin plate lysis area increased. Attacks of thrombophlebitis stopped completely in 13 patients, though five patients later suffered recurrences and phenformin had to be added to their treatment. Fibrinolytic enhancement with stanozolol seems to be effective in this previously intractable condition, and regular blood studies will indicate which patients also need phenformin.
Rare TLR2 mutations reduce TLR2 receptor function and can increase atopy risk
Authors: M. S. D. Kormann, R. Ferstl, M. Depner, N. Klopp, S. Spiller, T. Illig, C. Vogelberg, E. Von Mutius, C. J. Kirschning, M. Kabesch
Journal: Allergy (2009)

Background: Common genetic variations in toll‐like receptor 2 (TLR2), an innate pathogen recognition receptor, may influence the development of atopic diseases. So far, very little is known about the role of rare TLR2 mutations in these diseases. Objective: We investigated the functional properties of six rare amino acid changes in TLR2 (and one amino acid change in a TLR2 pseudogene) and studied their effect on atopic sensitization and disease. Methods: We identified rare TLR2 mutations leading to amino acid changes from databases. Functional effects of TLR2 variants were analyzed by NF‐κB‐dependent luciferase reporter assay and interleukin‐8 enzyme linked immunosorbent assay in vitro . The frequency of these mutations was determined in a random sample of the general population ( n = 368). Association with atopic diseases were studied in a cross sectional German study population ( n = 3099). Results: Three out of six mutations in the TLR2 gene altered receptor activity in vitro . Out of these, only the minor allele of R753Q occurred reasonably frequent in the German population (minor allele frequency 3%). The risk to develop atopy increased by 50% in carriers of the 753Q allele ( P = 0.021) and total ( P = 0.040) as well as allergen specific serum IgE levels ( P = 0.011) were significantly elevated. Conclusion: The rare but functionally relevant mutation R753Q in TLR2 may significantly affect common conditions such as atopic sensitization in the general population.
Acute Intermittent Porphyria
Authors: Selvyn B. Bleifer, Stephan J. Alphas
Journal: New England Journal of Medicine (1959)

IN recent years much has been learned about the nature of the metabolic defects in the various porphyrias1 2 3 4 and of the hereditary nature of these conditions.5 , 6 However, there have been few reports of acute intermittent porphyria in children, and the presence of porphobilinogen in the urine of children is an exceedingly rare finding.5 , 7 The syndromes associated with the various porphyrias have been described extensively,5 , 7 , 8 and it is not the purpose of this communication to discuss the clinical features of acute intermittent porphyria. The following case is presented because of the unusual finding of porphobilinogen in the urine of 4 of . . .
Prognostic Value of Fetal Hemoglobin Levels in Acquired Aplastic Anemia
Authors: Gerald E. Bloom, Louis K. Diamond
Journal: New England Journal of Medicine (1968)

Total fetal hemoglobin values (milligrams of fetal hemoglobin per 100 ml of blood) were determined in 30 children with acquired aplastic anemia. Seventeen of 18 patients who died (95 per cent) had less than 400 mg per 100 ml of total fetal hemoglobin whereas 11 of 12 who are alive (92 per cent) and doing well had more than 400 mg per 100 ml of total fetal hemoglobin at the initial examination. The results suggest that the total fetal hemoglobin concentration may reflect the extent of injury to the bone marrow and may be of prognostic value in determining which patients with acquired aplastic anemia are likely to respond to treatment.
Advocacy Groups Urge Congress to Ensure All Immigrant Children Have Health Care
Authors: Mike Mitka
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abdominal Pain With Calcific Density in the Right Upper Quadrant
Authors: Dale E. Wenlund
Journal: JAMA (1966)

Dr. Jack Wittenberg: This was the first hospital admission of a 30-year-old man who complained of abdominal pain of 36 hours' duration. The pain began with a chilly sensation associated with diffuse abdominal discomfort which steadily increased. He had diarrhea for which he took kaolin mixture with pectin (Kaopectate) with minimal relief. On the morning of admission he awoke with increasing pain and was anorectic. By the time he came into the emergency ward, the pain was severe and steady, and had localized to the right of the umbilicus, and radiated into the right flank. On physical examination, the patient's temperature was 102 F (38.9 C) and his pulse rate was 104 beats per minute. There was muscle spasm in the mid and upper abdomen on the right, with localized abdominal tenderness and rebound tenderness lateral to the umbilicus. Bowel sounds were normal, and no masses were felt. Laboratory examination
The Inferior Venacavagram and Lymphoproliferative Disorders
Authors: Harold Simon
Journal: JAMA (1963)

WE FEEL that the proper management of patients with lymphoproliferative disorders or Hodgkin's disease necessitates as complete a knowledge of the anatomical extent of disease as possible. Systemic symptoms, often without local manifestations, may result from retroperitoneal involvement which may be quite occult. Various methods have been used to study the retroperitoneal space.<sup>1-7</sup>Recently, we have used visualization of the inferior vena cava to evaluate the retroperitoneal involvement as suggested by others<sup>1,5,6</sup>who have stressed the ease of the procedure. The normal anatomy and abnormal findings have been well described by Sammons et al6 and others.<sup>2,4</sup> <h3>Method</h3> We have used a modification of the procedure of Sammons et al.<sup>6</sup>Patients were premedicated with 25-50 mg of promethazine (Phenergan) hydrochloride, and 50 mg of meperidine hydrochloride, and nothing was given by mouth for at least 4 hr prior to the examination. The skin over the femoral vein
Turkey Diet Regime in the Treatment of Psoriasis
Authors: Agnese Kelley
Journal: British Journal of Dermatology (1972)

Journal Article Turkey Diet Regime in the Treatment of Psoriasis Get access Agnese Kelley Agnese Kelley Department of Dermatology Belfast City Hospital Belfast BT9 7AB Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 86, Issue 4, 1 April 1972, Pages 440–441, https://doi.org/10.1111/j.1365-2133.1972.tb05064.x Published: 01 April 1972
Pseudomonas Polysaccharide (Piromen®) in the Evaluation of the Hypothalamus-Pituitary-Adrenal Cortical Axis.
Authors: W. D. Hawley
Journal: Annals of Internal Medicine (1967)

s1 May 1967Pseudomonas Polysaccharide (Piromen®) in the Evaluation of the Hypothalamus-Pituitary-Adrenal Cortical Axis.W. D. Hawley, M.D. (Associate), C. Y. Bowers, M.D., F.A.C.P.W. D. Hawley, M.D. (Associate)Search for more papers by this author, C. Y. Bowers, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1028_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA commercially available nonprotein polysaccharide-nucleic acid complex prepared fromPseudomonas(Piromen®) is used as a standardized stimulus to evaluate the function of the hypothalamus-pituitary-adrenal cortical axis in hospitalized or ambulatory patients. The test is performed as follows: 2.5 ml plasma are obtained from blood collected in a heparinized vacuum tube at 8AMafter an overnight fast; Piromen, 0.1 µg/kg of body weight, is given intravenously; and 2.5 ml of plasma are obtained 2 hr later. Plasma cortisol concentration is determined by a fluorometric procedure. Simplicity and lack of serious side effects recommend the test for a variety of studies.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Orleans, Louisiana PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHYPOTHESES CONCERNED WITH AXONAL REGENERATION IN THE MAMMALIAN NERVOUS SYSTEMAn explanation of axonal regeneration in peripheral nerves and its failure in the central nervous systemEnhancement of axonal regeneration in the brain of the rat by corticotrophin and triiodothyronine 1 May 1967Volume 66, Issue 5Page: 1028-1028KeywordsAttentionBlood plasmaBody weightCortisolHematologic testsPolysaccharidesPseudomonas Issue Published: 1 May 1967 PDF DownloadLoading ...
Renal developmental defects resulting from in utero hypoxia are associated with suppression of ureteric β-catenin signaling
Authors: Lorine J. Wilkinson, Cailda S. Neal, Reetu R. Singh, Duncan B. Sparrow, Nyoman D. Kurniawan, Adler Ju, Stuart M. Grieve, Sally L. Dunwoodie, Karen M. Moritz, Melissa H. Little
Journal: Kidney International (2015)
Platelets in Thrombocythemia
Authors: CHRISTOPHER Y. THOMAS
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 June 1978Platelets in ThrombocythemiaCHRISTOPHER Y. THOMAS IV, M.D.CHRISTOPHER Y. THOMAS IV, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-6-845_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent article by Dr. Wu (Ann Intern Med 88:7-11, 1978) adds valuable data to the study of platelet disorders in patients with myeloproliferative diseases. I have, however, several reservations about the implications of this study.Dr. Wu successfully treated six patients suffering thrombotic symptoms with the antiplatelet drugs aspirin and dipyrimadole. There are potential problems with this approach. Many authors have described patients with manifestations of both thrombosis and hemorrhage (1, 2). Adams, Schutz, and Goldberg (3) have shown an exaggerated response of the bleeding time in several patients with myeloproliferative disorders given aspirin. We recently...References1. OZER F, WAYNE E, MIESCH D, and LEVIN W: Primary hemorrhagic thrombocythemia. Am J Med 28:807-823, 1960 CrossrefMedlineGoogle Scholar2. MCCLURE P, INGRAM G, STACEY R, GLASS U, and MATCHETT M: Platelet function tests in thrombocythemia and thrombocytosis. Br J Haematol 12:478-497, 1966 CrossrefMedlineGoogle Scholar3. ADAMS T, SCHUTZ L, and GOLDBERG L: Platelet function abnormalities in the myeloproliferative disorders. Scand J Haematol 13:215-224, 1974 CrossrefMedlineGoogle Scholar4. SINGH A and WETHERLY-MEIN G: Microvascular occulsive lesions in primary thrombocythemia. Br J Haematol 36:553-564, 1976 CrossrefGoogle Scholar5. MARTINEZ J, SANDOR S, and HOLBURN R: Metabolism of human prothrombin and fibrinogen in patients with thrombocytosis secondary to myeloproliferative states. Blood 42:35-46, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHRISTOPHER Y. THOMASIV, M.D.Affiliations: Oncology-Hematology Division University of Cincinnati College of Medicine Cincinnati, OH 45267 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEssential thrombocythemias. Clinical evolutionary and biological dataAntipyretic analgesics 1 June 1978Volume 88, Issue 6 Page: 845-846 Keywords Aspirin Drugs Hemorrhage Myeloproliferative disorders Platelets Thrombocytosis Thrombosis ePublished: 1 December 2008 Issue Published: 1 June 1978 PDF downloadLoading ...
Urban hypothermia in the west of Scotland
Authors: L J Hislop, J P Wyatt, G W McNaughton, A J Ireland, T H Rainer, G Olverman, L M Laughton
Journal: BMJ (1995)

To our knowledge, the epidemiology of hypothermia in Britain is unknown: there have been no studies in a large population. Concerns about risks of hypothermia in socially isolated elderly people have resulted in calls for efforts aimed at prevention.1 Controversy about the increased cost of fuel have added to these concerns.2

Patients presenting to hospital in Glasgow, Paisley, Coatbridge, or Airdrie with rectal temperatures below 35°C were studied prospectively during the winter of 1993-4 (1 December to 31 March). All eight accident and emergency departments serving a continuous, defined urban population participated. Accident and emergency staff and ambulance crews collected data. Patients' relatives, neighbours, and general practitioners and social services departments provided additional information. Patients were followed up to discharge, transfer to long stay wards, or death.

Ninety three patients presented with hypothermia. Given that the study …
Robert James Sanderson
Authors: Gillian MacDougall, David Sim, Paul Sanderson, Christine Tolsma
Journal: BMJ (2007)

Robert Sanderson (“Rob”) was an exemplary head and neck surgeon, specialising in the treatment of ear, nose, and throat malignancies. He was a proud Lancashire man, and he and his brother Paul were the first set of identical twins to pass the FRCS in general surgery together. After working for the late Professor Philip Stell …
NPHS2 mutation analysis shows genetic heterogeneityof steroid-resistant nephrotic syndrome and lowpost-transplant recurrence
Authors: Stefanie Weber, Olivier Gribouval, Ernie L. Esquivel, Vincent Morinière, Marie-Josèphe Tête, Christophe Legendre, Patrick Niaudet, Corinne Antignac
Journal: Kidney International (2004)
Ecology in Evolution
Authors: Thomas H. Lee
Journal: New England Journal of Medicine (2001)

“Current discussions about medical care appear largely concerned with two questions: Is the burgeoning harvest of new knowledge fostered by immense public investment in medical research being delivered effectively to the consumers? Is the available quantity, quality and distribution of contemporary medical care optimum in the opinion of the consumers?” These sentences could have been written anytime in recent years, but they were the opening of an article entitled “The Ecology of Medical Care” that appeared in the Journal in 1961.1 Its quantitative description of the way in which people in the United States and Britain seek and receive health . . .
Is Childhood Leukemia the Price Of Modernity ?
Authors: T. Reynolds
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Is Childhood Leukemia the Price Of Modernity ? Get access Tom Reynolds Tom Reynolds Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 8, 19 April 1995, Pages 560–562, https://doi.org/10.1093/jnci/87.8.560 Published: 19 April 1995
Abstract 71: Meningioma: response to retinoids and radiation therapy.
Authors: Xuan Ren, Hannah Lo, Robert Vanderwaal, Jerry Jaboin
Journal: Cancer Research (2013)

Abstract Meningioma represents one third of all primary central nervous system neoplasms. Most meningiomas are effectively addressed by surgical resection. However unresectable, partially resected, recurrent and high grade meningiomas are also typically treated with adjuvant or definitive radiation therapy. Retinoids are a class of compounds structurally related to Vitamin A. Retinoic acid (RA), the active derivative of vitamin A and the first diffusible morphogen in vertebrates, has recently been evaluated for its chemotherapeutic and chemopreventive attributes in solid tumors. Additionally, a novel orally bioavailable synthetic retinoid, fenretinide, has been tested with different pharmacokinetics, side effect profile, and mechanism of action than the classic retinoids, all-trans retinoic acid (ATRA) and 13-cis-retinoic acid (13CRA). In this project, we study the effects of retinoic acid agents alone and in combination with ionizing radiation in meningioma cell lines (IOMM-Lee and CH157MN). We demonstrate that ATRA, 13CRA and fenretinide have similar (increasing) toxicity profiles in both cell lines at doses above 1μM; but below this concentration there are minimal changes on cellular proliferation. Pretreatment of meningioma cell lines with ≤1μM doses of ATRA and 13CRA protected cells from radiation-induced cell death, while pre-treatment with fenretinide had no effect. Using flow cytometric analysis, we demonstrated that RA inhibited radiation-induced G2/M phase accumulation. Western blot result showed that ionizing radiation increased Phospho-Chk1 and -Chk2 levels, and decreased the levels of cdc25c, Phospho-cdc25c (Ser126) and Phospho cdc25c(THr68), Pre-treatment with RTRA reversed each of these effects in a dose- and time-dependent manner. These data suggest a role for the classic RAs in radiation protection through modulation of DNA repair through cell cycle checkpoint pathways. Fenretinide, however, works through a different mechanism, and does not result in radiation protection. These divergent roles suggest that fenretinide may escape the concerns of radiation protection of earlier retinoids making it a promising agent for tumor treatment in the periradiotherapy period. Citation Format: Xuan Ren, Hannah Lo, Robert Vanderwaal, Jerry Jaboin. Meningioma: response to retinoids and radiation therapy. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 71. doi:10.1158/1538-7445.AM2013-71
If “tracking” is category-specific a “common structure” may be redundant
Authors: Pascal Boyer
Journal: Behavioral and Brain Sciences (1998)

Identifying objects as members of ontological domains activates category-specific processes. There is evidence that these processes include particular ways of “tracking” substances and could do all the “tracking” necessary for concept acquisition. There may be no functional need or evolutionary scenario for a general tracking capacity of the kind described by Millikan.
Aqueous Quaternary Ammonium Antiseptics and Disinfectants
Authors: Richard E. Dixon
Journal: JAMA (1976)

HOSPITAL personnel often assume that liquid antiseptics and disinfectants will sterilize treated objects. However, as these agents are usually used in hospitals, they do not eradicate contamination, but rather, can only be relied on to reduce surface contamination to a level unlikely to be hazardous. Too often, they do not even achieve this degree of decontamination, since the effectiveness of a liquid antiseptic or disinfectant depends on its strength, activity, and duration of contact with the contaminated surface, as well as the nature and extent of the contamination. In addition, these agents may themselves be contaminated with potential pathogens. For these reasons, these agents may not prevent, indeed, they may even cause, patient infection. Among the various agents used in hospitals, the aqueous quaternary ammonium compounds (AQACs) have been frequently implicated as a cause of infection because of intrinsic contamination or a lack of effectiveness against certain pathogens. Kaslow and
Low birth weight.
Authors: N. G. O'Brien, S. P. Dundon
Journal: BMJ (1970)

report on aids for the disabled' said, "In theory wheel chairs are prescribed by consul- tants, but in practice few consultants have studied this problem adequately and the re- sponsibility is often passed on to social workers or appliance clerks who have not been trained to do this work.Part of the fault stems from gaps in the doctor's educa- tion, particularly at a postgraduate level, but the situation could be improved by delegating responsibility to physiotherapists or occupational therapists specially trained to assess patients and their wheel-chair needs."The B.M.A. working party estimated that possibly as high as 30% O. of wheel chairs were unsuitable for the patient concerned.This may well be an underestimate.-Weare, etc.,
Health Care System: The American Model
Authors: Viktor Praznikov
Journal: JAMA (1994)

This book about the American health care system interestingly was published in Russia. Ten years ago nobody would have imagined that such a book would be written in Russia. But today, it is not only possible, it has been done. Since August 1991, the best-known reforms have been conducted in the fields of economics, politics, and the social system. Not as well known is the fact that the health care system has also been the subject of reforming trends. But what is the best beginning for change? Many analysts of the Russian health care system would like to know what is the most efficient system to serve as a model for the new Russian system of health care. Ideally, it should be one that serves the common good of society. During the totalitarian era in the former Soviet Union, there were no objective books on Western health care systems. The