tbuckley/cabot-search huggingface dataset:
Perceived Level of Life Enjoyment and Risks of Cardiovascular Disease Incidence and Mortality
Authors: Kokoro Shirai, Hiroyasu Iso, Tetsuya Ohira, Ai Ikeda, Hiroyuki Noda, Kaori Honjo, Manami Inoue, Shoichiro Tsugane
Journal: Circulation (2009)

Background— Perceived level of life enjoyment, a positive psychological condition that reflects the ability to engage pleasurably with the environment, may relate to risks of cardiovascular disease. This prospective cohort study attempted to examine the effects of perceived level of life enjoyment on cardiovascular disease incidence and mortality among Japanese community residents. Methods and Results— Subjects were 88 175 Japanese men and women 40 to 69 years of age who were free of cardiovascular disease at baseline and followed up for a median of 12.0 years and were included in the Japan Public Health Center–Based (JPHC) Study Cohort. Data about psychological conditions and other confounding variables were obtained through self-administered questionnaires. Information on incidence and mortality for cardiovascular disease was collected through registered hospitals and public health centers. The multivariable hazard ratios of cardiovascular disease incidence for men in the high versus low perceived levels of life enjoyment group were 1.22 (95% confidence interval, 1.01 to 1.47) for stroke and 1.23 (95% confidence interval, 1.05 to 1.44) for total cardiovascular disease. As for mortality, Japanese men with low perceived level of life enjoyment showed increased risk: hazard ratios of 1.75 (95% confidence interval, 1.28 to 2.38) for stroke, 1.91 (95% confidence interval, 1.30 to 2.81) for coronary heart disease and 1.61 (95% confidence interval, 1.32 to 1.96) for total cardiovascular disease. For women, however, the perceived level of life enjoyment was not associated with risks of cardiovascular disease incidence or mortality. Conclusion— A lower perceived level of life enjoyment was found to be associated with higher risks of cardiovascular disease incidence and mortality among middle-aged men, suggesting a protective role of positive psychological conditions on cardiovascular disease.
Use of a risk factor and dietary calcium questionnaire in predicting bone density and subsequent bone loss at the menopause.
Authors: T D Spector, A C Edwards, P W Thompson
Journal: Annals of the Rheumatic Diseases (1992)

One hundred and thirty six healthy white females within 30 months of their last menstrual period (mean age 52 years) were examined to determine the usefulness of a risk factor questionnaire in predicting bone density and subsequent loss. Bone density was assessed at baseline and at 12 monthly intervals. None of the proposed risk factor variables with the exception of nulliparity correlated with the baseline spinal or femoral bone density. As a predictor of bone loss only drinking alcohol (more than four units/day) was significant. A risk factor score derived from the questionnaire before its administration did not correlate with baseline bone density or subsequent bone loss. In most normal women questioned soon after a natural menopause, an estimate of bone density and subsequent bone loss and hence osteoporotic risk cannot be reliably made using a simple risk factor questionnaire.
Intestinal Angina With Malabsorption Treated by Elective Revascularization
Authors: Herbert Dardik
Journal: JAMA (1965)

Recognition of the syndrome of intestinal angina is important in view of the paucity of cases described in the literature and the excellent results that may be obtained by proper diagnosis and surgical intervention. Improved radiologic techniques and the development of sophisticated tests for evaluating intestinal absorption have added immeasurably to both diagnostic acuity and postoperative evaluation. A clinical case of intestinal angina is diagnosed preoperatively and successfully revascularized utilizing a prosthetic bypass graft.
Hyperbaric Oxygen in the Treatment of Actinomycosis
Authors: Sylvan D. Manheim
Journal: JAMA (1969)

Perirectal actinomycosis in a 63-year-old woman responded to hyperbaric oxygen therapy. Though perirectal actinomycosis is a relatively rare lesion, further trial of hyperbaric oxygen therapy is indicated in the treatment of actinomycotic infections in general.
Imatinib dose escalation for chronic phase–chronic myelogenous leukaemia patients in primary suboptimal response to imatinib 400 mg daily standard therapy
Authors: D Rea, G Etienne, S Corm, P Cony-Makhoul, M Gardembas, L Legros, V Dubruille, S Hayette, F-X Mahon, J-M Cayuela, F E Nicolini
Journal: Leukemia (2009)
Effectiveness of Endoscopic Drainage for Pancreas Divisum: Endoscopic and Surgical Results in 31 Patients
Authors: J. H. Siegel, J. S. Ben-Zvi, W. Pullano, A. Cooperman
Journal: Endoscopy (1990)

See also: Association of Annular Pancreas and Pancreas DivisumEndoscopy 1991; 23(05): 310-311DOI: 10.1055/s-2007-1010703 See also: Re: Effectiveness of Endoscopic Drainage for Pancreas DivisumEndoscopy 1991; 23(02): 107-107DOI: 10.1055/s-2007-1010629 See also: Re: Effectiveness of Endoscopic Drainage for Pancreas Divisum, Endoscopy 20 (1990) 129Endoscopy 1991; 23(02): 107-108DOI: 10.1055/s-2007-1010630
Hypertension Screening of 1 Million Americans
Authors: Jeremiah Stamler, Rose Stamler, Wallace F. Riedlinger, George Algera, Richard H. Roberts
Journal: JAMA (1976)

During 1973 through 1975, more than 1 million persons were screened in the nationwide Community Hypertension Evaluation Clinic (CHEC) program at 1,171 sites. While those screened were not from defined populations, findings paralleled those of recent surveys of US population samples. First, CHEC confirmed the scope of the problem of elevated blood pressure in the United States. Of those screened, 247 of 1,000 had a diastolic reading of 90 mm Hg or higher; 116 of 1,000 had a reading of 95 mm Hg or greater. Prevalence of elevated blood pressure rose with age up to age 50 years, was higher in blacks than in whites, and was higher in men than in women. Second, CHEC data confirmed the challenge of undetected, untreated, and uncontrolled hypertension. Previously undetected hypertension was present in 27.7% of hypertensive people, detected but untreated in 10.7%, and treated but uncontrolled in 16.7%—totaling 55.1%. (<i>JAMA</i>235:2299-2306, 1976)
<sup>131</sup>I-Tositumomab Therapy as Initial Treatment for Follicular Lymphoma
Authors: Mark S. Kaminski, Melissa Tuck, Judith Estes, Arne Kolstad, Charles W. Ross, Kenneth Zasadny, Denise Regan, Paul Kison, Susan Fisher, Stewart Kroll, Richard L. Wahl
Journal: New England Journal of Medicine (2005)

Advanced-stage follicular B-cell lymphoma is considered incurable. Anti-CD20 radioimmunotherapy is effective in patients who have had a relapse after chemotherapy or who have refractory follicular lymphoma, but it has not been tested in previously untreated patients.Seventy-six patients with stage III or IV follicular lymphoma received as initial therapy a single course of treatment with 131I-tositumomab therapy (registered as Tositumomab and Iodine I 131 Tositumomab [the Bexxar therapeutic regimen]). This consisted of a dosimetric dose of tositumomab and 131I-labeled tositumomab followed one week later by a therapeutic dose, delivering 75 cGy of radiation to the total body.Ninety-five percent of the patients had any response, and 75 percent had a complete response. The use of polymerase chain reaction (PCR) to detect rearrangement of the BCL2 gene showed molecular responses in 80 percent of assessable patients who had a clinical complete response. After a median follow-up of 5.1 years, the actuarial 5-year progression-free survival for all patients was 59 percent, with a median progression-free survival of 6.1 years. The annualized rate of relapse progressively decreased over time: 25 percent, 13 percent, and 12 percent during the first, second, and third years, respectively, and 4.4 percent per year after three years. Of 57 patients who had a complete response, 40 remained in remission for 4.3 to 7.7 years. Hematologic toxicity was moderate, with no patient requiring transfusions or hematopoietic growth factors. No cases of myelodysplastic syndrome have been observed.A single one-week course of 131I-tositumomab therapy as initial treatment can induce prolonged clinical and molecular remissions in patients with advanced follicular lymphoma.
Father and Child: Developmental and Clinical Perspectives
Authors: Howard A. Winkler
Journal: JAMA (1982)

<i>Father and Child: Developmental and Clinical Perspectives</i>, edited by Stanley H. Cath, MD, Alan R. Gurwitt, MD, and John Munder Ross, PhD, proves to be an exciting, interesting, and provocative book and can be recommended to a variety of audiences. The credentials of the three editors are impressive, and their skill and literacy are borne out not only in their own individual contributions but in their masterful editing of a large number of authors. Despite the many authors, the quality of the material remains high throughout, again a credit to the editors. The purpose of this collection of essays is to reflect on the significance of the relationship of the father to his children and the child to his father from a strongly psychoanalytic viewpoint and is seen from empirical and clinical as well as speculative aspects. The goal is admirably achieved, as most of the essays conclude with a
Immune responses in human infections with Brugia malayi: specific cellular unresponsiveness to filarial antigens.
Authors: W F Piessens, P B McGreevy, P W Piessens, M McGreevy, I Koiman, J S Saroso, D T Dennis
Journal: Journal of Clinical Investigation (1980)

We evaluated the cellular immune competence of 101 subjects living in an area of South Kalimantan (Borneo) where Malayan filariasis is endemic. All patients with elephantiasis but none with other clinical stages of filariasis reacted with adult worm antigens. The majority of subjects without clinical or parasitological evidence of filariasis and approximately one-half of those with amicrofilaremic filariasis reacted with microfilarial antigens. In contrast, most patients with patent microfilaremia did not respond to microfilarial antigens. The in vitro reactivity of all patient categories to nonparasite antigens was similar to that of the distant control group. These results indicate that patent microfilaremia is associated with a state of specific cellular immune unresponsiveness and are consistent with the current hypothesis that the various clinical manifestations of filariasis result from different types of immune responses to distinct antigens associated with different developmental stages of filarial worms.
Hyperplasia of the Adrenal Medulla
Authors: W. Drukker, P. Formijne, J. B. v. d. Schoot
Journal: BMJ (1957)

As an incidental observation, it was noted that com- pletely adrenalectomized monkeys given 2-8 mg. of Me-F-COL per day rapidly died showing a syndrome characterized by acute cardiovascular damage and leucocytic infiltrations, especially in the liver and kidney.
Should physicians be routinely involved in the care of elderly surgical patients? No
Authors: B. Herd
Journal: BMJ (2011)

Standards of care for elderly people in hospital have come under the spotlight. <b>Kathy Wilkinson</b> and <b>Helen Wilson (</b>doi:10.1136/bmj.d1070) believe that geriatricians can help improve the management of surgical patients, but <b>Barbara Herd </b>is concerned that the dilution of resources will harm those who most need specialist attention
Violence, Abuse, and Asthma in Puerto Rican Children
Authors: Robyn T. Cohen, Glorisa J. Canino, Hector R. Bird, Juan C. Celedón
Journal: American Journal of Respiratory and Critical Care Medicine (2008)

Puerto Ricans have the highest prevalence of and morbidity from asthma of all ethnic groups in the United States. One potential contributor to the high burden of asthma in Puerto Rican children is exposure to stress and violence.To examine whether exposure to stress and violence is associated with an increased risk of asthma among Puerto Rican children.This study was a population-based probability sample of children in the San Juan and Caguas metropolitan areas in Puerto Rico. Information was collected in a household survey of 1,213 children and their primary caretakers.The prevalence of lifetime physician-diagnosed asthma was 39.6%. In the year before the survey, 14% of children had witnessed an act of violence, 7% had been victims of violence, and 6% had been victims of physical or sexual abuse. Although stressful life events and exposure to neighborhood violence were not associated with asthma, a history of physical or sexual abuse was associated with approximately twice the odds of current asthma (odd ratio [OR], 2.52; 95% confidence interval [CI], 1.27-5.00), health care use for asthma (OR, 1.95; 95% CI, 0.96-3.96), and medication use for asthma (OR, 2.35; 95% CI, 1.05-5.26).Physical or sexual abuse is associated with high asthma morbidity among Puerto Rican children. To our knowledge, this is the first report of an association between childhood abuse and asthma. Our findings highlight the importance of screening for asthma among victims of childhood abuse, and to be aware of the possibility of physical or sexual abuse among children with asthma.
The long-term results of cartilage removal alone for the treatment of chondrodermatitis nodularis
Authors: None Hudson-Peacock, None Cox, None Lawrence
Journal: British Journal of Dermatology (1999)

Cartilage excision alone has been demonstrated to be an effective technique in the treatment of chondrodermatitis nodularis (CDN), and in the short term is associated with an 80% cure rate. The objective of this study was to demonstrate that long-term disease control could be achieved using this surgical technique. Set in three hospital dermatology departments, 94 patients with CDN affecting the helix and antihelix were contacted by postal questionnaire at least 6 months after surgery. Replies were received from 77; 11 patients had died and six could not be traced. The main outcome measure was the identification of those patients in remission and those with disease recurrence. Sixty-two helix lesions were followed up for a mean of 52 months (range 8-99). There was recurrence in 10 patients (all men; 16%). Twenty antihelix lesions were followed up for a mean of 55 months (range 8-93). There was recurrence in five patients (all women; 25%). In conclusion, this study confirms that only cartilage needs to be excised for the long-term effective treatment of CDN. The only relevant aetiological factor identified was that all except one patient slept on the same side as the CDN. We believe that pressure on the ear during sleep causes CDN. This is most evident on the most protuberant part of the ear.
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus
Authors: David M Levine, Weronica E Ek, Rui Zhang, Xinxue Liu, Lynn Onstad, Cassandra Sather, Pierre Lao-Sirieix, Marilie D Gammon, Douglas A Corley, Nicholas J Shaheen, Nigel C Bird, Laura J Hardie, Liam J Murray, Brian J Reid, Wong-Ho Chow, Harvey A Risch, Olof Nyrén, Weimin Ye, Geoffrey Liu, Yvonne Romero, Leslie Bernstein, Anna H Wu, Alan G Casson, Stephen J Chanock, Patricia Harrington, Isabel Caldas, Irene Debiram-Beecham, Carlos Caldas, Nicholas K Hayward, Paul D Pharoah, Rebecca C Fitzgerald, Stuart MacGregor, David C Whiteman, Thomas L Vaughan
Journal: Nature Genetics (2013)
ABO Blood Groups and Acute Respiratory Virus Disease
Authors: J. C. McDonald, A. J. Zuckerman
Journal: BMJ (1962)

the results of isolation and serological tests for human A2 viruses among swine, cattle, poultry, dogs, cats, and horses before and after an epidemic in Ireland are presented.There was no evidence for the presence of either Shope or A2 virus among swine.The results for cattle were also uniformly negative.Cats, dogs, and poultry show a small number of positives with A2/Asia/57 virus.Reasons are given for regarding the positive results as non-specific.Among horses A/equi/Praha virus, or one closely related to it, may be present, but no epizootic due to it has been described and no strains of it have been isolated.Positive results with A2/Asia/57 and A2/ Eire/8/61 were obtained, but none with A2/Asia/57 (Ashton) or A2/Singapore/W/ 1/57.Technical and epidemiological reasons are given for regarding the positive results as non-specific.It is concluded that there is no reservoir of A2 viruses in animals in Ireland, and that no spread to them occurred during the January, 1961 epidemic.
Five gene probes carry most of the discriminatory power of the 70-gene risk model in multiple myeloma
Authors: C J Heuck, P Qu, F van Rhee, S Waheed, S Z Usmani, J Epstein, Q Zhang, R Edmondson, A Hoering, J Crowley, B Barlogie
Journal: Leukemia (2014)

Five gene probes carry most of the discriminatory power of the 70-gene risk model in multiple myeloma
Antireticulin antibody in systemic sclerosis.
Authors: T Mahmud, M Peakman, G Senaldi, A McWhirter, C M Black, D Vergani
Journal: Annals of the Rheumatic Diseases (1990)

The prevalence, immunoglobulin class, and IgG subclass of antireticulin antibody in the serum samples of 32 patients with systemic sclerosis were investigated by indirect immunofluorescence on unfixed rodent tissue. Antireticulin antibody was present in 22/32 (69%) of patients and belonged to the IgG class in 19/22 (86%), the IgA class in 13/22 (59%), and the IgM class in 6/22 (27%) of positive sera. IgG1 was the predominant subclass of IgG antireticulin antibody, occurring either alone or in association with IgG3 in 12/19 cases (63%). Thus antireticulin antibody of the IgG and IgA classes is found in most patients with systemic sclerosis. The finding of an autoantibody with reactivity for collagen-like fibres in systemic sclerosis indicates that the antibody has a potential role in the pathogenesis of the disease, and as it belongs to the IgA class this suggests that it arises in response to antigens presented to the immune system at the mucosal level.
Thomas Gareth Jones
Authors: Niall Martin
Journal: BMJ (2004)

An icon in the treatment of Lassa feverIn early 2000 Dr Bill Aldis, then the World Health Organization's representative in Sierra Leone, remembers getting a worried call from Geneva: "I've got an ICRC [International Committee of the Red Cross] staff member with suspected Lassa fever just evacuated from Kenema [in Sierra Leone].What do I do?" Dr Aldis replied, "The best thing you could do is put him on an airplane and get him back to Kenema-there's a hospital there with the world's greatest expert in Lassa fever, a guy named Conteh . .."Such was the reputation of Aniru Conteh, who ran the world's only Lassa fever isolation ward.Born in 1942 in Jawi Folu, Eastern Province, Sierra Leone, Aniru Conteh was the son of the local chief.At the age of 16 he left home to go to school in the country's capital, Freetown, where he went on to study chemistry and biology at Fourah Bay College.Initially he worked as a teacher, but in 1974 he enrolled as a medical student at the University of Ibadan in Nigeria, where he continued to work after qualifying, until he returned to Sierra Leone in 1979 and started working on the Lassa fever programme.Lassa fever takes its name from a small village in Nigeria, where a mysterious outbreak in a mission hospital in 1969 led to the three mission nurses becoming infected.Two of the nurses died, but the third survived and was evacuated to the Colombia Presbyterian Hospital in New York.Wilbur
THE DIAGNOSIS AND TREATMENT OF SCIATICA: WITH A NOTE ON THE METHODS IN USE AT HARROGATE
Authors: W. B. Watson
Journal: BMJ (1912)

I~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ñegative result, as was also the diazo reactioni for the urine.T1If chest was aspirated for the last time on October 19th, much le,s fluid beiDg founId 'ha-i on Abe previous occasions.The patient now became gra(iully weaker anid mliore emaciated, sufferinig occasionally from alarming attacks of syuicopei She died during her sleep on December 2nd.At the post-miortem)i examiination the following observation-s vere made:Abdomen: Iiitestines evervwhere roughened with nodular Thronic granulations anid coated with a layer of lymph, the ntestinal coils being adherent and the omentum thickenie(l.Liver enlarged and fatty, -pale in colour, and showing the 'haracteristic appearanices of passive congestion.Kidneys and spleen iiormal.Clhest: The pericardium was greatly thickened and its cavity completely obliterated by firm fibrouis adlhesions between i s twvo surfaces.T-he orifices of the superior and inferior venae cavae were contracted.:The right pleural cavity was obliterated by adhesions, the lower lobe of the lunIg being congested, oederkatous, and partly collapsed.The utpper lobe Was congested and studded with small hard tuberculous nodules; Tle -left pleural cavity was obliterated in its upper half bv pleuritic adhesions, and shut off frQm the lower part, which containied, about a pint of serous fluid.The lower lobe of the left lunig was collapsed, and the npper lobe containied the same tuberculous-looking no(lules as the right lung.They were arraniged in scattered groups, but
Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia
Authors: Changshan Wang, Goro Sashida, Atsunori Saraya, Reiko Ishiga, Shuhei Koide, Motohiko Oshima, Kyoichi Isono, Haruhiko Koseki, Atsushi Iwama
Journal: Blood (2014)
Methadone Maintenance Patients in General Medical Practice
Authors: David M. Novick
Journal: JAMA (1988)

Medical maintenance is the treatment by primary care physicians of rehabilitated methadone maintenance patients who are stable, employed, not abusing drugs, and not in need of supportive services. In this research project, physicians with experience in drug abuse treatment provided both the pharmacologic treatment of addiction as well as therapy for other medical problems, as needed. Decisions regarding treatment were based on the individual needs of the patient and on currently accepted medical practice rather than on explicit regulations. We studied the first 40 former heroin addicts who were transferred to this program from more conventional methadone clinics. At a follow-up visit at 12 to 55 months, 33 (82.5%) of 40 patients had remained in treatment; five (12.5%) had been discharged because of cocaine abuse and two (5%) had been voluntarily discharged. Personal benefits of medical maintenance include the dignity of a standard professional atmosphere and a more flexible reporting schedule. This program has the potential for improving treatment of selected methadone maintenance patients.
Anatomical distribution of bronchoalveolar lavage fluid as assessed by digital subtraction radiography.
Authors: C A Kelly, C J Kotre, C Ward, D J Hendrick, E H Walters
Journal: Thorax (1987)

A digital subtraction imaging technique was used to visualise directly the anatomical distribution of 3 X 60 ml aliquots of saline containing a low concentration of radio-opaque dye, introduced sequentially into a segment of the middle lobe. It was possible to estimate the relative movement of fluid within the segment during the sequential aspiration of each of these aliquots. The first 60 ml aliquot introduced stayed close to the bronchoscope and probably sampled only the proximal airways. With the introduction of cumulative volumes of 120 ml or more, the fluid filled the segment more evenly. Aspiration then moved fluid back from the periphery, implying that the aspirate had also lavaged both distal airways and alveoli.