Fulminant Hepatitis A in Intravenous Drug Users with Chronic Liver Disease
Authors: Evangelos A. Akriviadis
Journal: Annals of Internal Medicine (1989)

Brief Reports15 May 1989Fulminant Hepatitis A in Intravenous Drug Users with Chronic Liver DiseaseEvangelos A. Akriviadis, MD, Allan G. Redeker, MDEvangelos A. Akriviadis, MD, Allan G. Redeker, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-10-838 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFulminant hepatitis is a rare complication of acute hepatitis A infection, with an estimated case fatality rate of 0.14% among hospitalized patients (1). Hepatitis A is transmitted primarily by the fecal-oral route (1). There has been an increased incidence of hepatitis A infection among intravenous drug users (2-5), and percutaneous transmission has been established in animals (6) and in humans (7-9). Whether mode of transmission and preexistent liver disease alter the usually benign course of hepatitis A infection is not known.We report here four cases of fulminant hepatic failure associated with hepatitis A infection encountered in intravenous drug users...References1. Lemon S. Type A viral hepatitis. New developments in an old disease. N Engl J Med. 1985;313:1059-67. CrossrefMedlineGoogle Scholar2. Havens W. Infectious hepatitis. Medicine (Baltimore). 1948;27:279-326. CrossrefMedlineGoogle Scholar3. WidellHanssonMoestrupSerleusMathiesenJohnson AGTZLT. Hepatitis A in a Swedish community during a ten-year period (Abstract). In: Szmuness W, Alter HJ, Maynard JE, eds.Viral Hepatitis: 1981 International Symposium. Philadelphia: Franklin Institute Press; 1982:742. Google Scholar4. FrancisHadlerPrendergast DST. Occurrence of hepatitis A, B, and non-A/non-B in the United States. CDC sentinel county hepatitis study I. Am J Med. 1984;76:69-74. CrossrefMedlineGoogle Scholar5. DienstagAlaamaMosleyRedekerPurcell JAJAR. Etiology of sporadic hepatitis B surface antigen-negative hepatitis. Ann Intern Med. 1977;87:1-6. LinkGoogle Scholar6. MathiesenDruckerLorenzWagnerGeretyPurcell LJDJRR. Localization of hepatitis A antigen in marmoset organs during acute infection with hepatitis A virus. J Infect Dis. 1978;138:369-77. CrossrefMedlineGoogle Scholar7. HollingerKhanOefinger FNP. Posttransfusion hepatitis type A. JAMA. 1983;250:2313-7. CrossrefMedlineGoogle Scholar8. NobleKaneReevesRoeckel RMSI. Posttransfusion hepatitis A in a neonatal intensive care unit. JAMA. 1984;252:2711-5. CrossrefMedlineGoogle Scholar9. SeebergBrandbergHermodssonLarssonLundgren SASPS. Hospital outbreak of hepatitis A secondary to blood exchange in a baby (Letter). Lancet. 1981;1:1155-6. CrossrefMedlineGoogle Scholar10. Hepatitis A among drug abusers. MMWR. 1988;37:297-300, 305. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Evangelos A. Akriviadis, MD; Allan G. 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Laskin, MD, Martin Black, MD 15 May 1989Volume 110, Issue 10Page: 838-839KeywordsAcute liver failureAddictsChronic liver diseaseHepatitis AInfectious diseasesLiverLiver diseases ePublished: 1 December 2008 Issue Published: 15 May 1989 PDF downloadLoading ...