High-Dose Morphine Infusion Complicated by Chlorobutanol-Induced Somnolence
Authors: ROBERT DeCHRISTOFORO
Journal: Annals of Internal Medicine (1983)

Brief Reports1 March 1983High-Dose Morphine Infusion Complicated by Chlorobutanol-Induced SomnolenceROBERT DeCHRISTOFORO, M.S., R.Ph., BRIAN J. CORDEN, M.D., Ph.D, JERRY C. HOOD, M.S., R.Ph., PREM K. NARANG, Ph.D., IAN T. MAGRATH, M.B.ROBERT DeCHRISTOFORO, M.S., R.Ph., BRIAN J. CORDEN, M.D., Ph.D, JERRY C. HOOD, M.S., R.Ph., PREM K. NARANG, Ph.D., IAN T. MAGRATH, M.B.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-3-335 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOpiate analgesics, including morphine sulfate, are often the mainstay of pain control in the terminally ill cancer patient (1, 2). There have been recent reports of the safe and effective administration of morphine sulfate as continuous intravenous infusion (3-6). Respiratory depression is the major determinant of maximal dosage. Other side effects such as constipation, sleepiness, and hallucinations are well known, but not life-threatening.A patient with Ewing's sarcoma had pain poorly controlled with a continuous morphine infusion of up to 6.8 mg/kg body weight · h. This dose was in excess of any dose reported in the literature. The patient's...References1. BEAVER W. Management of cancer pain with parenteral medication. JAMA. 1980;244:2653-7. CrossrefMedlineGoogle Scholar2. NEWBURGERSALLAN PS. Chronic pain: principles of management. J Pediatr. 1981;98:180-9. CrossrefMedlineGoogle Scholar3. RUTTERMURPHYDUDLEY PFH. Morphine: controlled trial of different methods of administration for postoperative pain relief. Br Med J 1980;1:12-3 CrossrefGoogle Scholar4. FRASER D. Intravenous morphine infusion for chronic pain [Letter]. Ann Intern Med. 1980;93:781-2. LinkGoogle Scholar5. MISERMISERCLARK AJB. Continuous intravenous infusion of morphine sulfate for control of severe pain in children with terminal malignancy. J Pediatr. 1980;96:930-2. CrossrefMedlineGoogle Scholar6. HOLMES A. Morphine IV infusion for chronic pain. Drug Intell Clin Pharm. 1978;12:556-7. CrossrefGoogle Scholar7. FORRESTBROWNBROWN WWC. Dextroamphetamine with morphine for the treatment of postoperative pain. N Engl J Med. 1977;296:712-5. CrossrefMedlineGoogle Scholar8. BORODYCHINWAHGRAHAMWADEWILLIAMS TPGDK. Chlorbutol toxicity and dependence. Med J Aust. 1979;1:288. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Clinical Center Pharmacy and National Cancer Institute National Institutes of Health Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySummary of Torsades de Pointes (TdP) Reports Associated with Intravenous Drug Formulations Containing the Preservative ChlorobutanolInteractions at Human ether-à-go-go–Related Gene ChannelsNeurotoxicity of Intra-arterial Papaverine Preserved with Chlorobutanol Used for the Treatment of Cerebral Vasospasm After Aneurysmal Subarachnoid HemorrhageQTc interval prolongation associated with intravenous methadoneThe efficacy and side effects of continuous infusion intravenous morphine (CIVM) for pain and symptoms due to advanced cancerPharmaceutics for the anaesthetistDrug Information RoundsEmbryotoxic effects of chlorobutanol in cultured mouse embryosContinuous Intravenous Narcotic Infusions for Cancer PainGrand mal seizures associated with high-dose intravenous morphine infusions: incidence and possible etiologyFront Line DispatchTreatment of cancer pain of the head and neck by continuous intravenous infusion of high-dose morphine: Report of two casesThe Treatment of Cancer Pain in ChildrenPharmaceutical ExcipientsClearance of Continuous Intravenous Morphine for Severe Cancer PainConstant Morphine Infusion for Severe Sickle Cell Crisis PainPreparation of a Bulk Preservative Free Morphine Parenteral SolutionContinuous Intravenous Infusion of Opioid DrugsContinuous Intravenous Morphine Infusions for Terminal Pain Control: A Retrospective ReviewReplyContinuous infusion of opioid drugs in the treatment of cancer pain: Guidelines for useThe Treatment of Cancer PainSafety and efficacy of continuous intravenous morphine for severe cancer painComment on IV MorphineAntiseptic drugs and disinfectants 1 March 1983Volume 98, Issue 3Page: 335-336KeywordsAnalgesicsBody weightConstipationHallucinationsMorphineOpiatesSarcoma Issue Published: 1 March 1983 PDF downloadLoading ...