Hyperkalemia in Elderly Patients Receiving Standard Doses of Trimethoprim-Sulfamethoxazole
Authors: Geoffrey A. Modest
Journal: Annals of Internal Medicine (1994)

Letters1 March 1994Hyperkalemia in Elderly Patients Receiving Standard Doses of Trimethoprim-SulfamethoxazoleGeoffrey A. Modest, MD, Barbara Price, MD, and Nicholas Mascoli, MDGeoffrey A. Modest, MDBoston University; School of Medicine; Boston, MA 02118, Barbara Price, MDBoston University; School of Medicine; Boston, MA 02118, and Nicholas Mascoli, MDBoston University; School of Medicine; Boston, MA 02118Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-5-199403010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Greenberg and colleagues [1] ascribed the hyperkalemia found in some human immunodeficiency virus (HIV)-infected patients treated with high-dose trimethoprim to the drug's similarity to amiloride [2]. Recently, we saw a patient without the acquired immunodeficiency syndrome (AIDS) who developed hyperkalemia while receiving standard doses of trimethoprim.This patient, a healthy, active 72-year-old woman with a history of nonprogressive sarcoidosis not requiring medication and mild reactive airway disease treated as needed with an albuterol inhaler was hospitalized with tracheobronchitis and worsening of her reactive airway disease. Laboratory findings at admission were normal, with normal electrolytes (potassium, 4.8 mmol/L), ...References1. Greenberg S, Reiser IW, Chou SY, Porush JG. Trimethoprim-sulfamethoxazole induces reversible hyperkalemia. Ann Intern Med. 1993; 119:291-5. Google Scholar2. Velazquez H, Perazella MA, Wright FS, Ellison DH. Renal mechanism of trimethoprim-induced hyperkalemia. Ann Intern Med. 1993; 119:296-301. Google Scholar Author, Article, and Disclosure InformationAuthors: Geoffrey A. Modest, MD; Barbara Price, MD; Nicholas Mascoli, MDAffiliations: Boston University; School of Medicine; Boston, MA 02118 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTrimethoprim-associated electrolyte and acid-base abnormalitiesResponse to letter by Levine et al.Antimicrobial-Associated Renal Tubular AcidosisSulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolonesSevere hyperkalemia in two renal transplant recipients treated with standard dose of trimethoprim-sulfamethoxazoleTrimethoprim-Induced HyperkalaemiaHyperkalemic Ascending ParalysisMiscellaneous drugs with nephrotoxic potential (Sulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolones)Hyperkalemia in the elderlyHyperkalemia and Trimethoprim-SulfamethoxazoleAuthors' replyCLINICAL DECISIONS: Walking the Tightrope: The Challenge of Elder CareEffect of Standard-Dose Trimethoprim/Sulfamethoxazole on the Serum Potassium Concentration in Elderly MenSevere Hyperkalemia in a Geriatric Patient Receiving Standard Doses of Trimethoprim-SulfamethoxazoleSevere Hyperkalemia in a Geriatric Patient Receiving Standard Doses of Trimethoprim-SulfamethoxazoleANTIBIOTIC CONCERNS IN THE ELDERLYCase Report: Reversible Hyperkalemia Associated With Trimethoprim-SulfamethoxazoleCotrimoxazole 1 March 1994Volume 120, Issue 5Page: 437-438KeywordsAIDSDietHIVNephritisPotassiumRenal failureResearch laboratoriesSaline solutionsSaltsSarcoidosis ePublished: 15 August 2000 Issue Published: 1 March 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...