tbuckley/cabot-search huggingface dataset:
"HERMAN RUBIN AND CITROPHAN"
Authors: S. S. Goldwater
Journal: JAMA (1924)

<h3>To the Editor:</h3> —Some time ago my attention was called to the fact that a circular letter describing the "Citrophan" treatment was signed by Dr. H. H. Rubin, who described himself as "Physician to Mount Sinai Hospital." Dr. Rubin was not a physician to Mount Sinai Hospital but had merely been a subordinate clinical assistant in one of the branches of the outpatient service for a short period. As long ago as November, 1923, I remonstrated with him vigorously regarding the misleading character of his circular, and obtained his promise that the name of Mount Sinai Hospital would not thereafter be used in connection with Citrophan.
Prognostic Value of Dipyridamole-Thallium Myocardial Scintigraphy in Patients With Kawasaki Disease
Authors: Masao Miyagawa, Teruhito Mochizuki, Kenya Murase, Shuji Tanada, Junpei Ikezoe, Michihito Sekiya, Ken Hamamoto, Shuhei Matsumoto, Masaharu Niino
Journal: Circulation (1998)

Although coronary artery lesions are critical complications of Kawasaki disease, their long-term outcome is still unclear. It is sometimes difficult to monitor progressive changes from aneurysms to stenotic lesions because coronary angiography (CAG) cannot be repeated very often, especially in infants. Our prospective study was designed to evaluate the prognostic value of dipyridamole-thallium single-photon-emission CT (SPECT) in the long-term follow-up of patients with Kawasaki disease.Of 459 consecutive patients with Kawasaki disease, coronary aneurysms were detected in 90 cases by echocardiography during the acute stage. After paired studies of selective CAG and SPECT were conducted, all patients were followed up and monitored for the occurrence of any cardiac events for > or =8 years. During the follow-up interval, there were 15 cardiac events (1 death, 5 infarctions, 2 coronary artery bypass graft operations, and 7 occurrences of unstable angina). Of patients who had some event, thallium redistribution was found on SPECT in 14 (93%, P<0.001). Of the various clinical and scintigraphic image variables, the presence of thallium redistribution was the best multivariate independent predictor of a late cardiac event (chi2=57.8, P<0.0001). The number of aneurysms detected on CAG added minimal statistical improvement to the model (chi2=1.9, P=0.0009).Dipyridamole-thallium SPECT is safely performed and is useful and important for risk stratification in the long-term follow-up of patients with Kawasaki disease.
Potassium Levels After Acute Myocardial Infarction—Reply
Authors: David A. Morrow
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psychiatry and the Tranquilizers
Authors: Anthony Hordern
Journal: New England Journal of Medicine (1961)

THE major tranquilizers came into widespread psychiatric use in the early nineteen fifties, an epoch unique in its appreciation of the importance of psychiatric illness, its scientific and technologic mastery and its concern for the welfare of the individual citizen. After World War II, which directly and indirectly led to these changes, increasing scientific progress and the development of new technics, as Kline1 has pointed out, made a biochemicophysiologic approach to the etiology and treatment of mental illnesses especially attractive. The tranquilizers were thus introduced at a particularly opportune time in the development of psychiatry; moreover, their advent was socially . . .
Effect of [alpha ]-linolenic acid[ndash ]rich Camelina sativa oil on serum fatty acid composition and serum lipids in hypercholesterolemic subjects
Authors: Henna M. Karvonen, Antti Aro, Niina S. Tapola, Irma Salminen, Matti I.J. Uusitupa, Essi S. Sarkkinen
Journal: Metabolism (2002)
Effect of GM-CSF on immune, inflammatory, and clinical responses to ragweed in a novel mouse model of mucosal sensitization
Authors: Elizabeth C. Cates, Beata U. Gajewska, Susanna Goncharova, David Alvarez, Ramzi Fattouh, Anthony J. Coyle, José-Carlos Gutierrez-Ramos, Manel Jordana
Journal: Journal of Allergy and Clinical Immunology (2003)
A MULTICENTER, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED STUDY OF THE SAFETY AND TOLERANCE OF REGADENOSON IN PATIENTS WITH RENAL IMPAIRMENT
Authors: Karthikeyan Ananthasubramaniam, Robert Weiss, Barbara Klauke, Bruce McNutt, Kathleen Feaheny
Journal: Journal of the American College of Cardiology (2011)
Early Th1 Cell Differentiation Is Marked by a Tfh Cell-like Transition
Authors: Shingo Nakayamada, Yuka Kanno, Hayato Takahashi, Dragana Jankovic, Kristina T. Lu, Thomas A. Johnson, Hong-wei Sun, Golnaz Vahedi, Ofir Hakim, Robin Handon, Pamela L. Schwartzberg, Gordon L. Hager, John J. O'Shea
Journal: Immunity (2011)
Successful Treatment of Bile Duct Injury Inflicted during Laparoscopic Cholecystectomy by Endoscopic Retrograde Biliary Drainage
Authors: S. Obata, K. Araki, J. Mizutani, K. Fujioka, Y. Matsumoto, K. Maeda, K. Kimura
Journal: Endoscopy (1992)

See also: Gallstones: Laparoscopic Treatment, Intracorporeal Lithotripsy Followed by Cholecystostomy or Cholecystectomy - A Personal TechniqueEndoscopy 1989; 21(S 1): 373-374DOI: 10.1055/s-2007-1012994
FURTHER STUDIES ON THE OPHTHALMO-TUBERCULIN REACTION IN CATTLE
Authors: Eugene F. McCampbell
Journal: The Journal of Experimental Medicine (1908)

Our conclusions differ in a few points from those of our first work on this subject. We are able to sum up our observations in this series of experiments as follows: 1. The ophthalmo-tuberculin test is of limited value in the diagnosis of tuberculosis in cattle. In some cases the reaction is very slight (hyperæmia). In others more pronounced congestion with profuse exudates are noted. Accuracy of observation is important. We are inclined to rely primarily on the results of the first instillation of tuberculin. Second instillations in a few instances elicit reaction in non-tubercular animals. 2. In the majority of animals tested the reaction increased in its intensity with each subsequent instillation of tuberculin. This fact indicates the development of a local hypersusceptibility or anaphylaxis associated with a partial immunity; von Pirquet calls this condition "allergie" (9). 3. It is possible in some cases to create a condition of "allergie" in healthy cattle, when spaced instillations of tuberculin are made. It is evident, therefore, that the result of the first instillation of tuberculin should be made the only basis of diagnosis. Rosenau and Anderson (II) have recently called attention to this point in regard to the human subject. 4. When repeated instillations of tuberculin are made on the conjunctiva at short intervals (twenty-four hours, etc.) a local immunity results (No. 3D et al.). If the instillations are separated two weeks or more anaphylaxis results. 5. We, therefore, hold that if tuberculin (0.1 cubic centimeter) is carefully instilled into the conjunctival sac and if careful comparison of the instilled eye with the opposite eye shows that a reaction of varying intensity results in from ten to twelve hours after the first instillation, a tubercular lesion is present. 6. In our first report (7) we were inclined to believe that subcutaneous tubercular injection given previous to the ocular test would slightly inhibit it. We have since become convinced that this is true only to a limited extent, and that in some cases the ophthalmo-reaction is exaggerated by a subcutaneous injection of tuberculin. 7. The primary ophthalmo-tuberculin reaction is in direct proportion to the extent of the tubercular processes in the body. The more extensive the tubercular processes, the more anaphylactic the animal is. This is in direct variance with the condition in the usual subcutaneous tuberculin test. (See Necropsy Report.) 8. We are inclined to believe that the ophthalmo-tuberculin test will reveal tuberculosis at as early a state as the usual subcutaneous test. 9. The ophthalmo-reaction is of no value in determining whether vaccinated cattle are actively tubercular or not, or in demonstrating any hypersusceptibility in the offspring of tubercular cattle. 10. The cutaneous test from our brief series of experiments does not seem to be as accurate as the ophthalmic test. This conclusion has been reached by several investigators.
CAMPHOR LINIMENT POISONING
Authors: Henry H. Haft
Journal: JAMA (1925)

Camphor, when taken in very large doses, produces epileptiform convulsions, preceded by vertigo, excitement and delirium. Intense heat and burning may be felt in the mouth and in the abdomen. The case reported here is one of poisoning by camphor liniment, 1½ ounces (45 c.c.), taken by mistake under the impression that it was olive oil. <h3>REPORT OF CASE</h3> Mr. H. had been in the habit of taking olive oil periodically for "gallstones." It was customary for him to drink it while in the drug store. Immediately after taking his customary dose, he complained to the drug clerk that it didn't taste right, and that his mouth burned, whereupon the clerk hurriedly offered him some more, assuring the patient that this would taste better. On leaving the drug store, the patient began to complain of a burning sensation in the throat, retrosternum and in the pit of the stomach. He
Role of Autonomic Nervous System in the Pathogenesis of Prinzmetal's Variant Form of Angina
Authors: HIROFUMI YASUE, MASATO TOUYAMA, MITSUOMI SHIMAMOTO, HIROFUMI KATO, SATORU TANAKA, FUMIYA AKIYAMA
Journal: Circulation (1974)

In ten patients with Prinzmetal's variant form of angina the effects of various drugs were assessed: subcutaneous injection of methacholine (10 mg), atropine (0.7 mg), and epinephrine (0.7 mg); intravenous infusion of isoproterenol (20-25 µg/min); and in the three of the above patients who were having recurrent spontaneous attacks at the time of the examination, oral administration of atropine (0.6-1.2 mg), propranolol (30-90 mg), and phenoxybenzamine (10 mg in one patient). Master's triple two-step test and selective coronary arteriography were done on all the patients. In the three patients who were having spontaneous attacks at the time of the examination, the administration of methacholine induced the attacks and that of atropine suppressed the attacks. Epinephrine induced the attacks in two patients and propranolol was without effect in suppressing the attacks. Phenoxybenzamine (in one patient) suppressed the attacks. Neither Master's triple two-step test nor isoproterenol infusion precipitated the attacks, though heart rate increased to more than 110 beats/min and 160 beats/min respectively in all the patients. Coronary arteriograms were normal in seven of the ten patients. It is concluded that enhanced activity of the parasympathetic nervous system, which occurs at rest, is involved in the initiation of the attack by stimulating the sympathetic nerve which in turn probably induces coronary arterial spasm by way of activating alpha (vasoconstrictor) receptors present in the large coronary arteries.
BAALC and ERG expression levels are associated with outcome and distinct gene and microRNA expression profiles in older patients with de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
Authors: Sebastian Schwind, Guido Marcucci, Kati Maharry, Michael D. Radmacher, Krzysztof Mrózek, Kelsi B. Holland, Dean Margeson, Heiko Becker, Susan P. Whitman, Yue-Zhong Wu, Klaus H. Metzeler, Bayard L. Powell, Jonathan E. Kolitz, Thomas H. Carter, Joseph O. Moore, Maria R. Baer, Andrew J. Carroll, Michael A. Caligiuri, Richard A. Larson, Clara D. Bloomfield
Journal: Blood (2010)
Tuberculosis Control in New York City — A Changing Landscape
Authors: Michelle Macaraig, Joseph Burzynski, Jay K. Varma
Journal: New England Journal of Medicine (2014)

In New York City, which was the epicenter of the U.S. tuberculosis epidemic in the 1990s, funding for tuberculosis control has been cut by more than 50%, and in 2014 the city reported its first increase in cases after a decade of continuous reductions.
Transforming Growth Factor-β Production and Myeloid Cells Are an Effector Mechanism through Which CD1d-restricted T Cells Block Cytotoxic T Lymphocyte–mediated Tumor Immunosurveillance
Authors: Masaki Terabe, So Matsui, Jong-Myun Park, Mizuko Mamura, Nancy Noben-Trauth, Debra D. Donaldson, Wanjun Chen, Sharon M. Wahl, Steven Ledbetter, Bruce Pratt, John J. Letterio, William E. Paul, Jay A. Berzofsky
Journal: The Journal of Experimental Medicine (2003)

Our previous work demonstrated that cytotoxic T lymphocyte (CTL)-mediated tumor immunosurveillance of the 15-12RM tumor could be suppressed by a CD1d-restricted lymphocyte, most likely a natural killer (NK) T cell, which produces interleukin (IL)-13. Here we present evidence for the effector elements in this suppressive pathway. T cell–reconstituted recombination activating gene (RAG)2 knockout (KO) and RAG2/IL-4 receptor α double KO mice showed that inhibition of immunosurveillance requires IL-13 responsiveness by a non–T non–B cell. Such nonlymphoid splenocytes from tumor-bearing mice produced more transforming growth factor (TGF)-β, a potent inhibitor of CTL, ex vivo than such cells from naive mice, and this TGF-β production was dependent on the presence in vivo of both IL-13 and CD1d-restricted T cells. Ex vivo TGF-β production was also abrogated by depleting either CD11b+ or Gr-1+ cells from the nonlymphoid cells of tumor-bearing mice. Further, blocking TGF-β or depleting Gr-1+ cells in vivo prevented the tumor recurrence, implying that TGF-β made by a CD11b+ Gr-1+ myeloid cell, in an IL-13 and CD1d-restricted T cell–dependent mechanism, is necessary for down-regulation of tumor immunosurveillance. Identification of this stepwise regulation of immunosurveillance, involving CD1-restricted T cells, IL-13, myeloid cells, and TGF-β, explains previous observations on myeloid suppressor cells or TGF-β and provides insights for targeted approaches for cancer immunotherapy, including synergistic blockade of TGF-β and IL-13.
Scuba Diving and Bleomycin Therapy-Reply
Authors: Diane E. Stover
Journal: JAMA (1990)

<h3>In Reply.—</h3> I am in total agreement with Dr Zanetti's comment that although divers breathe compressed air, the percentage of oxygen they inspire may vary with the diving depth. The exact risk this poses to a previously bleomycintreated patient is not known. However, as pointed out by Dr Zanetti, these patients should be advised that theoretically there is a risk of developing pulmonary damage due to exposure to a higher partial pressure of inspired oxygen while scuba diving.
Consultants' response to clinical complaints
Authors: L. Mulcahy, M. Selwood
Journal: BMJ (1995)

EDITOR,—Nicholas Summerton reports a questionnaire survey of general practitioners to investigate their defensive medical practices.1 We recently completed a similar study for Oxford Regional Health Authority, which examined the impact of clinical complaints on hospital consultants. The views of all 848 consultants in the region were surveyed, and replies were received from 443 (52%), 246 of whom had received at least one complaint.

A major finding was that much activity in response …
An experimental model of postnatal jaundice in the suckling rat. Suppression of induced hyperbilirubinemia by Sn-protoporphyrin.
Authors: G S Drummond, A Kappas
Journal: Journal of Clinical Investigation (1984)

A model of experimental postnatal hyperbilirubinemia in the rat has been developed utilizing the heme precursor delta-aminolevulinic acid (ALA) to produce jaundice during a selective time period after birth. This time period is defined as that between 7 d postnatally, when the initial postpartum alterations of serum bilirubin and heme metabolism in the neonate have subsided, and 21 d, when the hepatic conjugation mechanism for the bile pigment appears fully developed. Administration of ALA in this time period led to a rapid, consistent, and significant dose-dependent increase in serum bilirubin levels in the newborn animals. Heme administration produced a qualitatively similar but enhanced effect. Both compounds, in addition, induced a dose-dependent increase in hepatic heme oxygenase activity concomitant with the increase in serum bilirubin levels. Neither compound increased serum bilirubin levels significantly when administered at or after 21 d postnatally. Administration of the synthetic metalloporphyrin, Sn-protoporphyrin, to ALA-treated neonates resulted in a dose-dependent decrease in serum bilirubin levels and hepatic heme oxygenase activity. Mn- and Zn-protoporphyrin in comparable doses did not significantly inhibit ALA-induced hyperbilirubinemia. Sn-protoporphyrin also inhibited the hyperbilirubinemia produced by heme in the suckling animals. ALA administration to newborn rats during the specific postnatal period described provides a simple and convenient model of experimental jaundice in the developing neonate which permits an examination of the potential ability of synthetic metalloporphyrins or other compounds to suppress induced hyperbilirubinemia in the newborn animal. The ability to induce a consistent and significant degree of jaundice in the postnatal rat by the method described may also be useful for other types of studies concerned with the biological disposition and effects of endogenously formed bilirubin in the neonate. The results of this study confirm in another model system the potent ability of Sn-protoporphyrin to suppress jaundice in the neonate, and suggest that suppression of heme oxidation by synthetic heme analogues may represent a useful therapeutic approach to the problem of severe hyperbilirubinemia in human premature newborn.
Abstract LB-342: Macrophage-secreted cytokines drive acinar-to-ductal metaplasia of the pancreas.
Authors: Geou-yarh Liou, Heike Doeppler, Peter Storz
Journal: Cancer Research (2013)

Abstract In response to inflammation, pancreatic acinar cells can undergo acinar-to-ductal metaplasia (ADM), a reprogramming event that induces transdifferentiation to a duct-like phenotype and in the context of additional oncogenic stimulation, contributes to development of pancreatic cancer. The signalling mechanisms underlying pancreatitis-inducing ADM are largely undefined. Our results provide evidence that macrophages infiltrating the pancreas drive this transdifferentiation process. We identify the macrophage-secreted inflammatory cytokines RANTES and TNFα as mediators of such signaling. Both RANTES and TNFα induce ADM through activation of nuclear factor κ-B and its target genes involved in regulating survival, proliferation and degradation of extracellular matrix. In particular we identify matrix metalloproteinases (MMPs) as targets that drive ADM, and provide in vivo data suggesting that MMP inhibitors may be efficiently applied to block pancreatitis-induced ADM in therapy. Citation Format: Geou-yarh Liou, Heike Doeppler, Peter Storz. Macrophage-secreted cytokines drive acinar-to-ductal metaplasia of the pancreas. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-342. doi:10.1158/1538-7445.AM2013-LB-342
Response to Comment on: Lipsky and Berendt. Hyperbaric Oxygen Therapy for Diabetic Foot Wounds: Has Hope Hurdled Hype? Diabetes Care 2010;33:1143–1145
Authors: Benjamin A. Lipsky
Journal: Diabetes Care (2011)

I thank van der Staal et al. (1) for their comments on our editorial (2). It is gratifying, and not surprising, to hear that hyperbaric oxygen therapy (HBOT), like many other aspects of health care, is less expensive in the Netherlands than in the U.S. Data from the U.K. also show that they can provide HBOT at a similar cost (£40/session, 2006 data) (3). Most hyperbaric therapy for lower extremity wounds in the U.S. is probably provided to patients who meet the Centers for Medicare …
Survival at a Gestational Age of 24 Weeks in the Netherlands—Reply
Authors: A. A. Eduard Verhagen, Annie Janvier
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Predictors of Treatment Utilization Among Women With Anorexia and Bulimia Nervosa
Authors: Pamela K. Keel, David J. Dorer, Kamryn T. Eddy, Sherrie S. Delinsky, Debra L. Franko, Mark A. Blais, Martin B. Keller, David B. Herzog
Journal: American Journal of Psychiatry (2002)

OBJECTIVE: The authors sought predictors of treatment utilization among women with eating disorders. METHOD: Women diagnosed with either anorexia or bulimia nervosa (N=246) completed prospective evaluations of eating disorder status, comorbid disorders, global assessment of functioning, and treatment utilization. RESULTS: Women with anorexia nervosa received significantly more inpatient treatment than did women with bulimia nervosa. Predictors of treatment utilization included lower global assessment of functioning scores and presence of personality disorders. CONCLUSIONS: Women with more severe pathology have higher treatment utilization rates. This pattern may explain the seeming lack of treatment efficacy for eating disorders outside of randomized controlled studies.