Phenacetin-induced Renal Disease in Rats
Authors: CHRISTOPHER C. FORDHAM
Journal: Annals of Internal Medicine (1965)

Article1 April 1965Phenacetin-induced Renal Disease in RatsCHRISTOPHER C. FORDHAM III, M.D., F.A.C.P., WILLIAM D. HUFFINES, M.D., LOUIS G. WELT, M.D., F.A.C.P.CHRISTOPHER C. FORDHAM III, M.D., F.A.C.P.Search for more papers by this author, WILLIAM D. HUFFINES, M.D.Search for more papers by this author, LOUIS G. WELT, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-4-738 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere is a growing body of clinical evidence suggesting a relationship between the excessive ingestion of analgesic medication and the development of chronic renal disease. The evidence is almost wholly circumstantial in character, and the available epidemiologic data are suggestive but not thoroughly convincing (1, 2). Acetophenetidin (phenacetin) or some metabolic product thereof has been the suspected offending agent in analgesic preparations on similar grounds. Although many efforts have been made to develop a reproducible experimental renal disease in laboratory animals using the ingredients of analgesic preparations, most have met with failure, and no reliable model has thus far been...References1. SCHREINER GA: The nephrotoxicity of analgesic abuse. Ann. Intern. Med. 57: 1047, 1962. LinkGoogle Scholar2. GILMAN A: Analgesic nephrotoxicity. Amer. J. Med. 36: 167, 1964. CrossrefMedlineGoogle Scholar3. MIESCHERSTUDER PA: Weitere tierexperimentelle untersuchungen zur frange der pathogenese der interstitiellen nephritis. Schweiz Med. Wschr. 91: 939, 1961. MedlineGoogle Scholar4. STUDERZBINDENFUST AGB: Weitere tierexperimentelle untersuchungen zur frange der schmerzmittelmissbrauch und interstitielle nephritis. Schweiz Med. Wschr. 88: 469, 1958. MedlineGoogle Scholar5. EISALOTALANTI AS: Observations on the effect of phenacetin and N-acetyl-p-aminophenol on rat kidneys. Acta Med. Scand. 169: 655, 1961. CrossrefMedlineGoogle Scholar6. CLAUSEN E: Nephrotoxic effect of phenacetin and acetylsalicylic acid in animal experiments. Acta Med. Scand. 172: 419, 1962. CrossrefMedlineGoogle Scholar7. CLAUSEN E: Histological changes in rabbit kidneys induced by phenacetin and acetylsalicylic acid. Lancet 2: 123, 1964. CrossrefMedlineGoogle Scholar8. ANGERVALLLEHMANNLINCOLN LLK: Induction of interstitial nephritis in rats fed phenacetin and NAPA (N-acetyl-p-aminophenol). Acta Path. Microbiol. Scand. 54: 274, 1962. CrossrefMedlineGoogle Scholar9. ABRAHAMSRUBENSTEINLEVIN EAHNW: Phenacetin induced papillary damage in experimental animals. Nature (London) 200: 695, 1963. CrossrefMedlineGoogle Scholar10. ANGERVALLLEHMANNBENGTSSON LLU: The renal concentrating capacity in albino rats after long-term consumption of phenacetin, NAPA (N-acetyl-p-aminophenol) and acetylsalicylic acid. Acta Med. Scand. 175: 155, 1964. CrossrefMedlineGoogle Scholar11. VAN SLYKENEILL DDJM: The determination of gases in blood and other solutions by vacuum extraction and manometric measurement. J. Biol. Chem. 61: 523, 1924. CrossrefGoogle Scholar12. MARSHFINGERHUTKIRSCH WHBE: Determination of urea nitrogen with the diacetyl method and an automatic dialyzing apparatus. Amer. J. Clin. Path. 28: 681, 1957. CrossrefMedlineGoogle Scholar13. COTLOVETRANTHAMBOWMAN EHVRL: An instrument and method for automatic, rapid, accurate, and sensitive titration of chloride in biologic samples. J. Lab. Clin. Med. 51: 461, 1958. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chapel Hill, North CarolinaFrom the Departments of Medicine and Pathology, University of North Carolina School of Medicine, Chapel Hill, N. C.This work was supported by training grants T1 AM 5054-08 and O8S1 and research grants HE-01301-11 and 5 RO1-HE-o1301-12 from the U. S. Public Health Service, Bethesda, Md.Dr. Huffines is a Markle Scholar in Academic Medicine; Dr. Welt's work is supported by Career Research Award 1-K6-AM-934-01.This paper was presented in part at the Annual Meeting of the American Federation for Clinical Research, Atlantic City, N. J., May, 1964, and at the Second International Symposium on the Biology of Pyelonephritis, Boston, Mass., June, 1964.Requests for reprints should be addressed to Christopher C. Fordham, III, M.D., Department of Medicine, University of North Carolina School of Medicine, Chapel Hills, N. C. 27515. 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DOSSETOR, M.A., B.M., B.CH., PH.D., F.R.C.P.(C)Ricerche Sperimentali Sulla Necrosi da Fenacetina Delle Papille RenaliLESIONS IN THE BLOOD SUPPLY OF THE PAPILLA IN EXPERIMENTAL ANALGESIC NEPHROPATHYLESIONS IN THE VASA RECTA IN EXPERIMENTAL ANALGESIC NEPHROPATHYImpairment of Renal Concentrating Capacity in Albino Rats Induced by Phenacetin and Acetylsalicylic AcidRESIDUAL RENAL DEFECTS IN NON‐FATAL PHENACETIN NEPHRITISANALGESIC NEPHROPATHY IN PERSPECTIVERenal Papillary Necrosis: a Critique of PathogenesisPhenacetin Nephropathy in a Mother and DaughterSURGICAL WOUND SEPSISANALGESIC ABUSE AND RENAL DISEASEIRREVERSIBILITY AFTER INIURYANALGESIC ABUSE AND RENAL DISEASEPhenacetin, aspirin, and kidney damagePHENACETIN AND RENAL PAPILLARY NECROSIS: RESULTS OF A PROSPECTIVE AUTOPSY INVESTIGATIONRENAL RETE MIRABILEEnvironment and the Kidney 1 April 1965Volume 62, Issue 4Page: 738-743KeywordsAcademic medicineAnalgesicsCareers in researchMedical servicesNecrosisPyelonephritisRenal diseasesResearch grantsResearch laboratoriesUnited States pharmacopeia Issue Published: 1 April 1965 PDF DownloadLoading ...