tbuckley/cabot-search huggingface dataset:
Serum S100 concentrations are not useful in predicting micrometastatic disease in cutaneous malignant melanoma
Authors: K. Acland, A.V. Evans, H. Abraha, C.M.J. Healy, P. Roblin, E. Calonje, G. Orchard, E. Higgins, R. Sherwood, R. Russell-Jones
Journal: British Journal of Dermatology (2002)

S100 protein is an acidic calcium binding protein that is expressed by melanoma cells. Elevated serum values of S100 have been described in metastatic disease and it has been suggested that it may be used as an adjunct to staging and monitoring of treatment. Micrometastatic disease in the sentinel lymph node can be demonstrated by sentinel node biopsy (SNB) and the sentinel node status is known to be the most important predictor of relapse.To determine whether serum S100 concentrations could predict the presence of micrometastatic disease.Thirty-one patients with primary cutaneous melanoma > 1 mm were recruited from referrals to the Melanoma clinic. All patients had serum S100 concentrations evaluated prior to undergoing SNB. Serum S100 concentrations were established using an immunoluminometric method. Sentinel nodes were identified using a dual technique with both radiolabelled colloid (residual from preoperative lymphoscintigraphy) and blue dye according to the MD Anderson Cancer Center protocol. Results Nine of these 31 patients had evidence of micrometastatic disease on SNB. The mean serum S100 concentration of those with positive SNBs was 0.027 microg L-1 compared with 0.045 microg x L(-1) in patients with negative SNBs (normal < 0.14 microg x L(-1)). No patient in the study demonstrated raised concentrations of serum S100.We conclude that serum S100 concentrations do not predict the presence of micrometastatic melanoma in sentinel nodes in primary cutaneous melanoma.
Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: a study by the Acute Leukemia French Association
Authors: A Renneville, N Boissel, O Nibourel, C Berthon, N Helevaut, C Gardin, J-M Cayuela, S Hayette, O Reman, N Contentin, D Bordessoule, C Pautas, S de Botton, T de Revel, C Terre, P Fenaux, X Thomas, S Castaigne, H Dombret, C Preudhomme
Journal: Leukemia (2012)
Clinical Application of an Improved Magnifying Fiber-Colonoscope (FCS-ML II), with Special Reference to the Remission Features of Ulcerative Colitis
Authors: Mamoru Nishizawa, Atsushi Kariya, Shigeo Kobayashi, Hikoo Shirakabe
Journal: Endoscopy (1980)

We have adapted a new, high-performance magnifying fibercolonoscope (FCS-ML II) developed by Machida Industries, for clinical use. We have observed the remission process of ulcerative colitis with this new instrument and have compared our findings with those obtained by clinical examination, X-ray, ordinary gastroscope, and histologic examination of biopsy specimens. Our results show that the findings of magnifying fibercolonoscopy correspond to those obtained with biopsy and histology, indicating that this new instrument promises to be a highly effective tool for the accurate assessment of the degree of remission of ulcerative colitis.
US health secretary pledges renewed fight against HIV
Authors: B. Roehr
Journal: BMJ (2009)

Great progress had been made in tackling AIDS in Africa, but efforts to curb the spread of the disease in the United States have “stalled,” the US health secretary, Kathleen Sebelius, told delegates to the National HIV Prevention Conference meeting in Atlanta, Georgia, on 24 August.

New HIV infections continue to occur at an estimated rate of more than 56 000 a year and deaths top 14 000, but US residents have grown complacent about the risks of infection, she said.

“In 1997, one in four Americans said they were ‘very concerned’ …
Interferon Regulatory Factor (Irf)-1 and Irf-2 Regulate Interferon γ–Dependent Cyclooxygenase 2 Expression
Authors: Jorge C. G. Blanco, Cristina Contursi, Cindy A. Salkowski, David L. DeWitt, Keiko Ozato, Stefanie N. Vogel
Journal: The Journal of Experimental Medicine (2000)

Cyclooxygenases (Cox) are rate-limiting enzymes that initiate the conversion of arachidonic acid to prostanoids. Cox-2 is the inducible isoform that is upregulated by proinflammatory agents, initiating many prostanoid-mediated pathological aspects of inflammation. In this study, we demonstrate that interferon (IFN)-gamma alone or in synergy with lipopolysaccharide (LPS) or interleukin 1alpha induces Cox-2 expression in mouse peritoneal macrophages, which is paralleled by changes in Cox-2 protein levels and prostaglandin E(2) (PGE(2)) release. Induction of Cox-2 was abrogated in macrophages that lack IFN regulatory factor (IRF)-1, consistent with an attenuated hepatic mRNA response in IRF-1(-/-) mice injected with LPS. Conversely, the absence of IRF-2 in macrophages resulted in a significant increase in both basal and inducible Cox-2 gene and protein expression as well as IFN-gamma-stimulated PGE(2) release, identifying IRF-2 as negative regulator of this promoter. Two IFN stimulation response elements were identified in the mouse Cox-2 promoter that were highly conserved in the human Cox-2 gene. Both bind endogenous IRF-1 and IRF-2 and regulate transcription in an IRF-1/2-dependent manner. Our data demonstrate conclusively the importance of IFN-gamma as a direct activator and coactivator of the Cox-2 gene, and the central role of IRF-1/2 family members in this process.
Penetration of piperacillin into bronchial mucosa and sputum.
Authors: G E Marlin, K R Burgess, J Burgoyne, G R Funnell, M D Guinness
Journal: Thorax (1981)

Bronchial mucosal biopsies were obtained during fibreoptic bronchoscopy in 12 patients receiving a new semisynthetic penicillin, piperacillin. The piperacillin levels estimated in bronchial mucosa exceeded those required to eradicate organisms associated with acute bronchitis, Haemophilus influenzae and Streptococcus pneumoniae, and compared favourably with those required for activity against a wide variety of anaerobic and Gram-negative organisms including Pseudomonas aeruginosa. Sputum and serum piperacillin levels were obtained from eight patients with bronchial disease receiving a five to seven day course (8 to 16 g/day). Sputum/serum level ratios were constant for the two dosages (10.7% for 8 g/day; 14.3% for 16 g/day) suggesting a diffusion transfer process, although the presence of pus in the sputum appeared to facilitate penetration. Seven patients achieved sputum levels exceeding those required for activity against Haemophilus influenzae and Streptococcus influenzae, and four for Pseudomonas aeruginosa. This study provides pharmacolinetic support of the use of piperacillin in bronchopulmonary infection.
Atenolol and Timolol, Two New Systemic β-Adrenoceptor Antagonists
Authors: Jan Koch-Weser, William H. Frishman
Journal: New England Journal of Medicine (1982)

ATENOLOL (Tenormin) and timolol (Blocadren) are two β-adrenoceptor antagonists recently released for clinical use in the United States (Fig. 1). They are the fourth and fifth systemic β-blockers to be approved by the Food and Drug Administration for the treatment of hypertension. Atenolol was released in 1981; like metoprolol, it is a β1-selective adrenergic blocker. However, unlike metoprolol, it has a long plasma half-life, which allows single daily doses in the treatment of hypertension.1 2 3 Timolol is a nonselective β-adrenergic blocker that has characteristics similar to those of propranolol but lacks membrane-stabilizing activity.1 It was approved by the FDA . . .
A prospective, randomized, double-blind, placebo-controlled study of orbital radiotherapy for Graves’ ophthalmopathy
Authors: Colum A Gorman, James A Garrity, Vahab Fatourechi, Rebecca S Bahn, Ivy A Petersen, Scott L Stafford, John D Earle, Glenn S Forbes, Robert W Kline, Erik J Bergstralh, Kenneth P Offord, Diana M Rademacher, Nancy M Stanley, George B Bartley
Journal: Ophthalmology (2001)
Obesity Interventions Can Improve More Than Just Body Mass Index
Authors: Aaron E. Carroll
Journal: JAMA Pediatrics (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
After-exercise thermography for predicting postoperative deep vein thrombosis.
Authors: H P Henderson, E D Cooke, S A Bowcock, J E Hackett
Journal: BMJ (1978)

After-exercise thermography of the legs was carried out on 50 patients before undergoing major abdominal surgery (group 1) and on 59 patients before elective hip surgery (group 2). The incidence of postoperative deep vein thrombosis (DVT)--diagnosed by the 125I-fibrinogen uptake test in group 1 and phlebography in group 2--was significantly higher in patients whose after-exercise thermogram (AET) had been abnormal. Out of 19 patients in group 1 and 30 in group 2 with a normal AET, two and nine repsectively developed postoperative DVT. Among patients with a unilaterally abnormal AET the incidences were 12 out of 19 patients in group 1 and five out of nine in group 2. The incidences among patients with a bilaterally abnormal AET rose to 11 out of 12 patients in group 1 and 15 out of 20 in group 2. Preoperative after-exercise thermography is a simple, objective test that identifies patients at high risk of developing postoperative thromboembolic disease.
Abstract 2942: The effect of AR expression level on the chromatin binding of the receptor
Authors: Alfonso Urbanucci, Biswajyoti Sahu, Janne Seppälä, Saara Kukkola, Kati Waltering, Harri Lähdesmäki, Olli Jänne, Tapio Visakorpi
Journal: Cancer Research (2010)

Abstract Treatment of castration resistant prostate cancer remains to be a challenge. Androgen receptor (AR) is overexpressed and still active at this stage of the disease. Our goal is to identify AR downstream genes and to study the effect of AR overexpression on the chromatin binding. We established, by stable transfection of wtAR into LNCaP cell, two cell lines that over express moderate (LNCaP-ARmo: 2-3 fold) and high (LNCaP-ARhi: 4-5 fold) receptor amounts of protein. We cultured the cell lines in androgen depleted medium for 4 days and subsequently treated them for 2 hours with vehicle or 1nM and 100nM of 5α-dihydrotestosterone (DHT). Subsequently, we used chromosome immunoprecipitation and deep sequencing (ChIP-seq) to identify AR binding. Expression profiling was done by Illumina array. The data analysis is ongoing. We first studied the well known AR target gene PSA. Our data indicated that in depleted medium there is not apparent difference in the loading of the promoter and enhancer of the PSA regulatory region in different cell lines. Instead, the promoter and the enhancer are more loaded in LNCaP-ARmo/−ARhi than in control cell line upon DHT stimulation. Our preliminary data show that there is a positive correlation between AR-levels and whole genome-wide binding upon stimulation with 1 nM DHT. Whereas, in 100 nM DHT, which is a saturating concentration of the ligand, there is a negative correlation. In the 1 nM DHT, AR seems to bind to different genomic loci in LNCaP-ARhi or ARmo than in control cells. In conclusions, the amount of AR has an effect on the chromatin binding of the receptor. Cells overexpressing AR seems to be more androgen-responsive. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2942.
Elevated C-Reactive Protein Is a Predictor of the Development of Diabetes in a General Japanese Population
Authors: Yasufumi Doi, Yutaka Kiyohara, Michiaki Kubo, Toshiharu Ninomiya, Yoshiyuki Wakugawa, Koji Yonemoto, Masanori Iwase, Mitsuo Iida
Journal: Diabetes Care (2005)

We examined the association between high-sensitivity C-reactive protein (CRP) levels and the development of diabetes in a general Japanese population.A total of 1,759 Japanese subjects, aged 40-79 years and without diabetes (according to American Diabetes Association fasting criteria), were stratified into three groups according to CRP tertiles by sex and followed up prospectively for a mean of 9.0 years.During the follow-up, 131 subjects (67 men and 64 women) developed diabetes. In both sexes, the age-adjusted cumulative incidence of diabetes increased significantly as the tertiles of CRP levels increased. In multivariate analyses, the risk of developing diabetes was significantly higher in the highest CRP tertile than in the lowest after adjustment for a number of confounding factors (odds ratio 2.63 [95% CI 1.23-5.65] for men and 2.25 [1.01-5.01] for women). In stratified analyses, this CRP-diabetes association was stronger in subjects without obesity or other risk factors related to insulin resistance and in nondrinking subjects.Our findings suggest that elevated CRP concentration is a significant predictor of diabetes in the general Japanese population, independent of obesity and insulin resistance.
In vivo leukemogenic potential of an interleukin 7 receptor α chain mutant in hematopoietic stem and progenitor cells
Authors: Kazuaki Yokoyama, Nozomi Yokoyama, Kiyoko Izawa, Ai Kotani, Akira Harashima, Katsuto Hozumi, Arinobu Tojo
Journal: Blood (2013)
A novel X-linked combined immunodeficiency disease.
Authors: E G Brooks, F C Schmalstieg, D P Wirt, H M Rosenblatt, L T Adkins, D P Lookingbill, H E Rudloff, T A Rakusan, A S Goldman
Journal: Journal of Clinical Investigation (1990)

A novel X-linked combined immunodeficiency disease was found in five living males in an extended family in the United States. The age of the affected males ranged from 2.5 to 34 yr. The most prominent clinical abnormalities were a paucity of lymphoid tissue; recurrent sinusitis, otitis media, bronchitis, and pneumonia; severe varicella; and chronic papillomavirus infections. The principal immunologic features of the disorder were normal concentrations of serum immunoglobulins but restricted formation of IgG antibodies to immunogens; normal numbers of B cells and NK cells but decreased numbers of CD4+ and CD8+ T lymphocytes, particularly the CD45RA+ subpopulations; diminished proliferative responses of blood T cells to allogeneic cells, mitogens and antigens; and decreased production of IL-2 by mitogen stimulated blood lymphocytes. Thus, affected males in this family carry an abnormal gene on their X chromosome that results in a combined immunodeficiency that is distinct from previously reported disorders.
ESSENTIAL FATTY ACIDS AND THE SKIN
Authors: C. Prottey
Journal: British Journal of Dermatology (1976)

Journal Article ESSENTIAL FATTY ACIDS AND THE SKIN Get access C. Prottey C. Prottey Environmental Safety Division, Unilever Research Laboratory Colworth/Welwyn, Colworth House, Sharnbrook, Bedford MK44 1LQ Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 94, Issue 5, 1 May 1976, Pages 579–587, https://doi.org/10.1111/j.1365-2133.1976.tb05151.x Published: 01 May 1976
Impaired Cell-Mediated Immunity in Patients with Classic Hemophilia
Authors: Michael M. Lederman, Oscar D. Ratnoff, James J. Scillian, Paul K. Jones, Bernice Schacter
Journal: New England Journal of Medicine (1983)

THREE cases of Pneumocystis carinii pneumonia, two of which were fatal, have recently been observed in patients with severe classic hemophilia who had been treated with lyophilized preparations of anti-hemophilic factor (factor VIII).1 Two of the patients also had oral candidiasis, and one was infected with Mycobacterium avium–intracellulare. Immunologic studies in the survivors demonstrated poor lymphocyte responsiveness to mitogens, an absolute and relative decrease in helper T cells, and a relative increase in suppressor T cells.The pathogenesis of this unusual syndrome, which resembles closely the acquired immunodeficiency syndrome (AIDS) that has been detected in homosexual men, Haitians, and . . .
False localising signs in the spinal cord
Authors: P. Goddard, C. Wakeley, A. Cook
Journal: BMJ (1996)

lack of evidence showing that such improved respi- ratory function is associated with a diminished incidence of clinically significant episodes of atelectasis.The central issue is that, despite optimum pain control and aggressive physio- therapy, about 10-15% of patients undergoing abdominal surgery develop a postoperative respiratory complication.There is a clear need to look beyond the simplistic paradigms relating to the pathophysiology of atelectasis that are implied in the letters by Sabanathan and colleagues, Haigh and Eden, and Quinn and Mallick.Higgs commented on the possibility of random confounding-that is, that randomisation may have resulted in groups that differ in regard to major risk factors.2However, as discussed above, differences in beliefs about the cause of atelectasis result in differing perceptions about the relative importance of various risk fac- tors.The selection of risk factors in the clinical trial was based on the results of our multivariate analysis of 1000 patients undergoing abdominal surgery.3Higgs can be reassured that there was good equivalence between the groups for the body mass index and the incidence of upper abdominal surgery.An attempt was made to measure "early ambulation" in an earlier study, but we found it impossible to reliably define and measure this important activity.Other issues must go unanswered as we neither evaluated patients undergoing thoracotomy nor made rec- ommendations about laparoscopic surgery.
SKETCH OF THE CHOLERA EPIDEMIC WHICH PREVAILED AT SOUTHAMPTON IN THE SUMMER OF 1849
Authors: W. S. Oke
Journal: BMJ (1853)

IInUTCAT, COMUNICATIONS, 273 so ever day.It is already attractin the attention of the legislature.In the army, it is an spensable r Si; in private practice, it is of parmount importance, buse the validity of vaccination depends on the skill and care of the vaccinator.
Breast Screening: Insurers Ordered to Pay
Authors: C. Vanchieri
Journal: JNCI Journal of the National Cancer Institute (1988)

Breast Screening: Insurers Ordered to Pay Cori Vanchieri Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 12, 17 August 1988, Pages 891–892, https://doi.org/10.1093/jnci/80.12.891 Published: 17 August 1988
Photo/essay. The human protein index
Authors: N. G. Anderson
Journal: JAMA (1981)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relational learning re-examined
Authors: Chris Thornton, Andy Clark
Journal: Behavioral and Brain Sciences (1997)

We argue that existing learning algorithms are often poorly equipped to solve problems involving a certain type of important and widespread regularity that we call “type-2 regularity.” The solution in these cases is to trade achieved representation against computational search. We investigate several ways in which such a trade-off may be pursued including simple incremental learning, modular connectionism, and the developmental hypothesis of “representational redescription.”
Intrapleural streptokinase versus urokinase in the treatment of complicated parapneumonic effusions: a prospective, double-blind study.
Authors: D Bouros, S Schiza, G Patsourakis, G Chalkiadakis, P Panagou, N M Siafakas
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Intrapleural administration of fibrinolytics has been shown in small numbers of patients with complicated parapneumonic effusions (CPE) and pleural empyema to be effective and relatively safe. Although streptokinase (SK) is recommended as the fibrinolytic of choice, there are no comparative studies among fibrinolytics. We therefore compared the efficacy, safety, and the cost of treatment two of the most used thrombolytics, SK and urokinase (UK). Fifty consecutive patients with CPE or empyema were randomly allocated to receive either SK (25 patients) or UK, in a double-blind fashion. All patients had inadequate drainage through chest tube (< 70 ml/24 h). Both drugs were diluted in 100 ml normal saline and were infused intrapleurally through the chest tube in a daily dose of 250,000 IU of SK or 100,000 IU of UK. The chest tube was clamped for 3 h after instillation. Response was assessed by clinical outcome, fluid drainage, chest radiography, pleural ultrasound, and/or computed tomography. Clinical and radiologic improvement was noted in all but two patients in each group, who required surgical intervention. The mean volume drained during the first 24 h after instillation was significantly increased; 380 +/- 99 ml for the SK group (p < 0.001) and 420.8 +/- 110 ml for the UK group (p < 0.001). The total volume (mean +/- SD) of fluid drained after treatment was 1,596 +/- 68 ml for the SK group, and 1,510 +/- 55 ml for the UK group (p > 0.05). The SK instillations (mean +/- SD) were 6 +/- 2.16 (range, 3 to 10) and those of UK 5.92 +/- 2.05 (range, 3 to 8). High fever as adverse reaction to SK was observed in two patients. The total cost of the drug in the UK group was two times higher than that of SK ($180 +/- 47 for SK and $320 +/- 123 for UK). The mean total hospital stay after beginning fibrinolytic therapy was 11.28 +/- 2.44 d (range, 7 to 15) for the SK group and 10.48 +/- 2.53 d (range, 6 to 18) for the UK group (p = 0.32). We conclude that intrapleural SK or UK is an effective adjunct in the management of parapneumonic effusions and may reduce the need for surgery. UK could be the thrombolytic of choice given the potentially dangerous allergic reactions to SK and relatively little higher cost of UK.
Double-blind, placebo-controlled immunotherapy with mixed grass-pollen allergoids III. Efficacy and safety of unfractionated and high-molecular-weight preparations in rhinoconjunctivitis and asthma
Authors: J BOUSQUET, H MAASCH, A HEJJAOUI, W SKASSABROCIEK, R WAHL, H DHIVERT, F MICHEL
Journal: Journal of Allergy and Clinical Immunology (1989)