tbuckley/cabot-search huggingface dataset:
Indomethacin--aspirin interaction: a clinical appraisal.
Authors: P M Brooks, J J Walker, M A Bell, W W Buchanan, A R Rhymer
Journal: BMJ (1975)

Plasma profiles of indomethacin after a 50-mg oral dose were constructed in six healthy volunteers before and after a week of aspirin treatment. Aspirin did not interfere with indomethacin plasma levels. To examine the clinical effect of concurrent indomethacin and aspirin treatment 20 patients with seropositive rheumatoid arthritis were given indomethacin 100 mg/day, aspirin soluble 4 g/day, and the two drugs taken together in random order. Analysis of the clinical indices of inflammation--articular index and mean pain score--and of the efficacy of each treatment showed no significant differences between the three treatment groups. With the proliferation in the number of anti-rheumatic drugs available, the case for giving two or more nonsteroidal anti-inflammatory drugs concurrently remains unproved.
Dose-dependent effect of adipose-derived adult stem cells on vertical bone regeneration in rabbit calvarium
Authors: Francesco Pieri, Enrico Lucarelli, Giuseppe Corinaldesi, Nicolò Nicoli Aldini, Milena Fini, Annapaola Parrilli, Barbara Dozza, Davide Donati, Claudio Marchetti
Journal: Biomaterials (2010)
Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant
Authors: Wies van Roosmalen, Sylvia E. Le Dévédec, Ofra Golani, Marcel Smid, Irina Pulyakhina, Annemieke M. Timmermans, Maxime P. Look, Di Zi, Chantal Pont, Marjo de Graauw, Suha Naffar-Abu-Amara, Catherine Kirsanova, Gabriella Rustici, Peter A.C. ‘t Hoen, John W.M. Martens, John A. Foekens, Benjamin Geiger, Bob van de Water
Journal: Journal of Clinical Investigation (2015)

Tumor cell migration is a key process for cancer cell dissemination and metastasis that is controlled by signal-mediated cytoskeletal and cell matrix adhesion remodeling. Using a phagokinetic track assay with migratory H1299 cells, we performed an siRNA screen of almost 1,500 genes encoding kinases/phosphatases and adhesome- and migration-related proteins to identify genes that affect tumor cell migration speed and persistence. Thirty candidate genes that altered cell migration were validated in live tumor cell migration assays. Eight were associated with metastasis-free survival in breast cancer patients, with integrin β3–binding protein (ITGB3BP), MAP3K8, NIMA-related kinase (NEK2), and SHC-transforming protein 1 (SHC1) being the most predictive. Examination of genes that modulate migration indicated that SRPK1, encoding the splicing factor kinase SRSF protein kinase 1, is relevant to breast cancer outcomes, as it was highly expressed in basal breast cancer. Furthermore, high SRPK1 expression correlated with poor breast cancer disease outcome and preferential metastasis to the lungs and brain. In 2 independent murine models of breast tumor metastasis, stable shRNA-based SRPK1 knockdown suppressed metastasis to distant organs, including lung, liver, and spleen, and inhibited focal adhesion reorganization. Our study provides comprehensive information on the molecular determinants of tumor cell migration and suggests that SRPK1 has potential as a drug target for limiting breast cancer metastasis.
DENTAL EDUCATION.A RETROSPECTIVE AND PROSPECTIVE VIEW.
Authors: John S Marshall
Journal: JAMA (1904)

"We will not anticipate the past, our retrospection will be all of the future." It is my purpose in this short paper to take a hasty retrospective glance at the history of dental education in the United State, that I may hold before you for a moment a picture of progress that has seldom been equaled in the history of educational advancement, and then to change the view and hold before you another picture, a prospective view, the realization of which will be no more difficult to us and our children than was that of the first picture to our fathers and ourselves. "Past and to come seems best; things present worse." Shakespeare never wrote a truer line than this, for, if we were satisfied with the present, there would be no progress in the future. Satisfaction with the present brought decay and ruin on the ancient Egyptians and on
Rights of Authors and of Patients
Authors: F. J. Ingelfinger
Journal: New England Journal of Medicine (1972)

What's a journal – almost any kind of journal – for? To offer its readers new information, new ideas, a different way of looking at things. Even a review article, if well done, permits new understanding of not so new facts. But to what avail is the article that merely restates that which the reader already knows or believes? The reader may feel gratified to see his own convictions endorsed, but the fare he has consumed is noncaloric; he has gorged himself on a psychologic pacifier. By the same token, the editor whose publication merely reflects the dominant ethos of . . .
Biological and Chemical Terrorism: A Guide for Healthcare Providers and First Responders
Authors: Diane O. Fleming
Journal: Annals of Internal Medicine (2003)

Medical Writings: Book Notes18 November 2003Biological and Chemical Terrorism: A Guide for Healthcare Providers and First RespondersDiane O. Fleming, PhDDiane O. Fleming, PhDFrom Bowie, MD, 20716.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-10-200311180-00037 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Weinstein RS and Alibek K. 161 pages. New York: Thieme Medical; 2003. $29.95. ISBN 1588901866. Order phone 800-782-3488.Field of medicine: Emergency medicine, infectious diseases, primary care, microbiology, toxicology, and public health.Format: Softcover book.Audience: First responders, including emergency department physicians, primary care physicians, and nurse practitioners. Infection control and biosafety professionals, industrial hygienists, homeland security officers, and biodefense personnel will also find this book a valuable resource.Purpose: To provide the information needed to handle a bioterrorist emergency with speed, accuracy, and confidence. The information can be used to develop tabletop or simulated bioterrorist exercises or for the ... Author, Article, and Disclosure InformationAffiliations: From Bowie, MD, 20716. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 18 November 2003Volume 139, Issue 10Page: 874KeywordsChartsInfectious diseasesInternetMicrobiologyMilitary medicineNursesPrevention, policy, and public healthPrimary care physiciansSoftware toolsToxicology ePublished: 18 November 2003 Issue Published: 18 November 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
949 EVOLUTION OF ANTIBIOTIC SUSCEPTIBILITY OF BACTERIA CAUSING SPONTANEOUS BACTERIAL PERITONITIS: A 9-YEAR STUDY
Authors: M. Concepción, M. Poca, J. Gordillo, C. Álvarez, C. Guarner-Argente, M. Casas, V. Hernández-Gea, E. Román, B. Mirelis, R. Pericas, G. Soriano, C. Guarner-Aguilar
Journal: Journal of Hepatology (2011)
Abrams Angiography: Vascular and international Radiology
Authors: John R. Charters
Journal: JAMA (1984)

This third edition ofAbrams Angiographyfollows the format of its predecessors, ie, contributions from many authors, both from the United States and Europe, under the general editorship of Herbert L. Abrams, MD. It is a formidable publication with about 1,900 illustrations and 2,400 pages. The 107 chapters cover topics from the history of angiography and the chemistry and pharmacology of contrast materials to catheters, lymphangiography, and topics in interventional radiology. Digital subtraction angiography is mentioned only briefly.  This textbook has many excellent sections. Examples include the eight chapters on coronary angiography, the discussion of both the radiology and physiology of the pulmonary circulation, the many chapters on renal arteriography and venography, the chapters on transhepatic portal venography, mesenteric ischemia, venography of the lower extremities, angiography of bones, joints, and soft tissues, and the entire lymphangiography section.  However, the book suffers from a certain degree of duplication and fragmentation. A
Hypomagnesemia in Neonatal Tetany Associated with Maternal Hyperparathyroidism
Authors: Norman H. Ertel, Joseph S. Reiss, Gabriel Spergel
Journal: New England Journal of Medicine (1969)

HYPOCALCEMIC tetany has been noted in the offspring of 13 mothers with primary hyperparathyroidism since the initial description by Friderichsen in 1938.1 Transplacental passage of the maternal elevated ionized calcium level leads to suppression of fetal parathyroid function, in addition, the neonate has immature kidneys and parathyroid glands that have limited ability to handle the high phosphate content of cow's milk. In such a neonate, we have noted hypomagnesemia in addition to the expected hypocalcemia.Case ReportA 14-day-old Negro male infant was admitted to the hospital because of intermittent twitching beginning 5 days earlier. On the day of admission . . .
Competition ratios for different specialties and the effect of gender and immigration status
Authors: Simon Lammy
Journal: Journal of the Royal Society of Medicine (2008)

Thank you for publishing the essay by McNally.1 It highlighted thoughts concerning competition for specialty places.

It is more striking to see real numbers quantifying the statistical fact that women are more successful at specialty selection than their male counterparts, than the often exaggerated tales from senior clinicians explaining such.

It could be an interesting exercise to see whether the increase of women in medicine, and as mentioned by the author concerning success rates for specialty posts ‘that women have such a high success rate because only the most able apply’ could impact upon the perceptions of success by men, so that only the most able apply from both sexes. Furthermore, it might be worth investigating in the future the impact such a gender imbalance has upon competition ratios for general practice.

As a student representative for progressive change concerning undergraduate medical education throughout my undergraduate medical career, it should be noted that significant progress has been made concerning the surgical specialties – the surgical colleges have demonstrated significant sustained interest in educating medical students and junior doctors concerning their craft.

The overwhelming emphasis should be on producing thorough careers advice to medical students from a holistic perspective. This is particularly relevant to my generation of medical students and junior doctors who must chose a specialty much earlier in their postgraduate, and even undergraduate, careers.

However, the significant careers advice that abounds concerning specialties can often be ignored by those meant to benefit – thus it should be encouraged that students should mould an investigative mindset that underpins success.
Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial
Authors: Kachit Choopanya, Michael Martin, Pravan Suntharasamai, Udomsak Sangkum, Philip A Mock, Manoj Leethochawalit, Sithisat Chiamwongpaet, Praphan Kitisin, Pitinan Natrujirote, Somyot Kittimunkong, Rutt Chuachoowong, Roman J Gvetadze, Janet M McNicholl, Lynn A Paxton, Marcel E Curlin, Craig W Hendrix, Suphak Vanichseni
Journal: The Lancet (2013)
Hormonal Therapy for Prostate Cancer in Men With Heart Disease
Authors: Neeraj Agarwal
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impaired thickening of nonischemic myocardium during acute regional ischemia in the dog.
Authors: J A Lima, L C Becker, J A Melin, S Lima, C A Kallman, M L Weisfeldt, J L Weiss
Journal: Circulation (1985)

To study the regional function of nonischemic myocardium after the onset of regional ischemia, graded circumflex coronary arterial stenosis was induced in 18 open-chest anesthetized dogs. Two-dimensional echocardiographic views were obtained at each degree of occlusion in a cross-sectional plane marked by two to three metal beads sewn to the left ventricular epicardium. Percent systolic thickening was measured at 16 equally spaced points around the left ventricle and correlated with microsphere-determined regional myocardial blood flow. Baseline thickening averaged 44.9 +/- 6.4%. During transmural ischemia percent systolic thickening decreased to -16.1 +/- 4.0% in the ischemic region and also decreased in adjacent nonischemic regions (to 2.4 +/- 2.4% in segments closest to the ischemic region [adjacent 1] and to 15.5 +/- 3.9 in segments further away [adjacent 2]), but was unchanged in segments directly opposite the ischemic region (remote region). During subendocardial ischemia, percent systolic thickening fell only in the ischemic and adjacent 1 regions (1.4 +/- 5.2% and 24.9 +/- 5.0%, respectively). Dipyridamole, 0.21 to 0.42 mg/min iv, given to seven dogs during transmural ischemia, caused a three- to fivefold increase in flow to the nonischemic and no change in flow to the ischemic region; function was not altered in any region. Propranolol, 0.1 mg/kg iv, was given to five dogs during transmural ischemia to depress contractility in the remote region. Percent systolic thickening fell in the remote (from 50.0 +/- 7.7% to 34.6 +/- 5.6%), but increased in adjacent 1 (from -0.25 +/- 3.7% to 15.2 +/- 3.9%) and in adjacent 2 (from 17.4 +/- 2.8% to 33.4 +/- 3.9%) regions, and remained unchanged in the ischemic region. We conclude the following: During transmural ischemia percent systolic thickening is markedly impaired in nonischemic myocardium immediately adjacent to the ischemic region, and is impaired to a lesser degree in regions located relatively far from the ischemic border. Dysfunction therefore overestimates the extent of regional ischemia after total coronary occlusion. During subendocardial ischemia function ceases in the ischemic region and functional impairment of nonischemic myocardium is restricted to immediately adjacent regions. Dysfunction of adjacent regions is not caused by "relative ischemia" related to increased local oxygen demands or to a steal phenomenon. Mechanical tethering of nonischemic myocardium adjacent to ischemic regions, secondary to changes in left ventricular shape during contraction, may contribute to the impairment of systolic thickening in adjacent regions during transmural ischemia.
Half of extra money for the NHS has gone on pay rises
Authors: Adrian O'Dowd
Journal: BMJ (2006)

Half the new investment in the NHS hospital budget in the past year has been spent on higher pay for staff, a new analysis of NHS finances has shown.

Another 27% went on increases in capital costs, the cost of clinical negligence, and the cost of drugs, and meeting the recommendations of the National Institute for Health and Clinical Excellence.

As a result the NHS is struggling to meet targets and government health priorities, the analysis by a leading health policy think tank says.

The King's Fund, which has published two briefing papers on NHS finances, has also called for the government to become more sophisticated in its planning for future spending before committing more money to the health service.

In one of the briefing papers, Where's the Money Going? , the charity has analysed new data from the Department of Health and calculated that only 13% of the extra £3.6bn ($6.1bn; €5.1bn) invested in the NHS hospital and community health services budget in 2005-6 was available for new developments and meeting targets and …
EXPERIMENTAL ERYTHROBLASTOSIS FETALIS IN RABBITS
Authors: Aaron Kellner, Emily F. Hedal
Journal: The Journal of Experimental Medicine (1953)

Female rabbits became immunized during pregnancy to the rabbit blood group factors G or g in five out of ten instances in which the red cells of the fetuses carried one of the factors absent in the mother. Antibodies so produced were of low titer and disappeared in all cases within 6 weeks after the birth of the litter. Repeated pregnancies did not result in additive increases in titer. Antibodies to the G-g factors, whether produced by the injection of red cells or by pregnancy, crossed the placenta readily from mother to fetus and were found at birth (and prior to nursing) associated with the red cells and in the serum of the fetuses. The rabbit placenta appeared to be equally permeable to the agglutinating and coating antibodies. The implications of these findings and their relation to the pathogenesis of erythroblastosis fetalis are briefly touched upon.
Abstract 3969: Stromal depletion of transforming growth factor receptor 2 promotes the development of forestomach squamous cell carcinoma
Authors: B R. Achyut, David A. Bader, Hannah H. Yan, Chaoyang Li, Yanli Pang, Li Yang
Journal: Cancer Research (2010)

Abstract Deletion or attenuation of transforming growth factor beta (TGFβ) signaling pathway has significant impact on human tumor development and progression. Specific deletion of transforming growth factor receptor 2 gene (Tgfbr2) in a subset of fibroblast (Tgfbr2fspKO, cre-mediated DNA recombination driven by fibroblast specific protein, FSP) specific promoter, leads to the development of squamous cell carcinoma of the forestomach in 100% of Tgfbr2fspKO mice by 6 Wks of Age. Here we dissect the underlying mechanisms. We first confirmed that deletion of Tgfbr2 is primarly restricted to the stromal components but not epithelial cells using TBR2 (TGFβR2) immunofluorescence and immunohistochemistry, which was done in both tumor tissue sections and cancer epithelial cells derived from tgfbr2fspKO mice. The functionality of TGFβ signaling was further examined in vivo by p-smad2 expression and nuclear localization which was clearly observed in the epithelial but not the stromal components. There was also a clear nuclear localization of p-smad2 protein in cultured cancer epithelial cells when treated with TGFβ1 (10 ng/ml). We further observed that stromal deletion of Tgfbr2 resulted in elevated proliferation of fibroblasts. In addition, there was a significantly increased inflammation in forestomach lesion which was featured by increased CD45+ leukocyte infiltration and elevated expression of inflammatory mediators COX2, NFkB, Akt. Interestingly, the alterations in epithelial cell compartment in Tgfbr2fspKO mice is very evident compared with floxed control littermates Tgfbr2fspKO mice, showing a significant enrichment of epithelial cancer stem cells. Our data demonstrate the importance of stromal TGFβ signaling mediated inflammation and carcinogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3969.
SOME COMPLETE URINE ANALYSES.
Authors: J. H. LONG
Journal: JAMA (1905)

A search through the chemical and physiologic literature will show that comparatively few complete analyses of urine, representing the full day's excretion, are on record. In the course of some other work, I found it necessary to make a number of lengthy determinations of this kind, and I present here the results obtained. Beside the organic substances, urea, uric acid and creatinin, the urine contains essentially combinations of three inorganic acids and five inorganic bases. That is, there are combinations of sodium, potassium, ammonium, calcium and magnesium with hydrochloric, sulphuric, and phosphoric acids, the last two being largely products of oxidation metabolism. Some of the text-books of urine analysis and of physiology make rather misleading statements about the relations which exist between these substances and the limits within which they vary; and the old errors are still repeated in regard to the normal volume of urine excreted. It is the
Abnormal hepatocystin caused by truncating PRKCSH mutations leads to autosomal dominant polycystic liver disease
Authors: Joost P. H. Drenth, Esa Tahvanainen, Rene H. M. te Morsche, Pia Tahvanainen, Helena Kääriäinen, Krister Höckerstedt, Jiddeke M. van de Kamp, Martijn H. Breuning, Jan B. M. J. Jansen
Journal: Hepatology (2004)

Mutations in protein kinase C substrate 80K-H (PRKCSH), encoding for the protein hepatocystin, cause autosomal dominant polycystic liver disease (PCLD), which is clinically characterized by the presence of multiple liver cysts. PCLD has been documented in families from Europe (Netherlands, Belgium, Finland) as well as from the United States. In this article, we report results from extensive mutational analysis of the PRKCSH gene in a group of 14 PCLD families and 65 singleton cases of Dutch and Finnish descent with multiple simple liver cysts. We identified PRKCSH mutations in 12 families and in 3 sporadic cases. In 8 of 10 Finnish families we detected the 1437+2delTG splice-site mutation. In Dutch families, we found 2 other mutations that affect correct splicing of PRKCSH: 292+1 G>C (2 families) and 1338-2 A>G (1 family). In another Dutch family, we detected a novel deletion (374-375delAG) in exon 6, predicting an abnormal shortened protein. Investigation of the carrier haplotypes identified a common founder chromosome in unrelated individuals in each of the 3 identified splice-site mutations. In 2 Finnish families with dominantly inherited PCLD, and in 62 of 65 sporadic cases with multiple simple liver cysts, we failed to demonstrate any PRKCSH mutation. This corroborates the notion that autosomal dominant PCLD is genetically heterogeneous. In conclusion, we propose that, on the basis of our results, genetic screening for PRKCSH gene mutations should be limited to patients either with a positive family history for PCLD or who have severe polycystic liver disease.