tbuckley/cabot-search huggingface dataset:
Oestrogen receptor proteins in malignant and fetal pancreas.
Authors: B Greenway, M J Iqbal, P J Johnson, R Williams
Journal: BMJ (1981)

High levels of high-affinity oestrogen binding were detected in cytosolic and nuclear fractions of tumour tissue from six patients with pancreatic carcinoma. Similar binding was found in fetal but not in normal adult pancreas, making depression of fetal genes a possibility. Specific androgen binding was not detectable. These findings suggest that anti-oestrogen treatment may offer a new approach to the treatment of pancreatic carcinoma.
Hospital Palliative Care Programs Raise Grade to B in New Report Card on Access
Authors: Rebecca Voelker
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trichilemmal cysts arising in an extensive comedo naevus
Authors: BARBARA J. LEPPARD
Journal: British Journal of Dermatology (1977)

A 25-year-old male is described who had extensive linear comedo naevi present from birth, involving the face, both sides of the trunk, both arms, one palm, both legs and one sole. Within these lesions multiple trichilemmal cysts were arising giving rise to a zosteriform pattern of skin nodules. Both lesions were confirmed histologically. It is suggested that comedo naevus is a hamartomatous abnormality of the hair follicle in which all layers, including the external root sheath, are involved and from which trichilemmal cysts may arise.
Jejunoileal Bypass: Pass It By
Authors: Charles B. Clayman
Journal: JAMA (1981)

Morbid obesity is defined as 100% or more above the ideal body weight, although no uniform definition has been accepted by all concerned. It is a disease that is associated with accelerated degeneration of important organ systems and a diminished quality of life and self-image.<sup>1,2</sup>Society often treats the condition with disdain, repulsion, or amusement and the victim as a freak. Acceptance of evidence that survival is decreased in this condition resulted in the development of jejunoileal (J-I) bypass. More recent data question impairment of survival in the absence of such risk factors as hypertension, diabetes, or hyperlipidemia.<sup>3</sup>Even more alarming is the number of serious complications that are associated with this procedure as it has found widespread use in many hospitals. The reports elsewhere in this issue (pp 970, 982) are only the latest in a long list of debilities or disorders produced by the effects of
Treatment options in Western hepatocellular carcinoma: a prospective study of 224 patients
Authors: Saša Markovič, Eldar Gadžijev, Borut Štabuc, Lory S. Croce, Flora Masutti, Miloš Šurlan, Pavel Berden, Erika Brenčič, Alenka Višnar-Perovič, Franco Sasso, Vera Ferlan-Marolt, Fabio Pozzi Mucelli, Rok Cesar, Massimo Sponza, Claudio Tiribelli
Journal: Journal of Hepatology (1998)
Traumatic Quadriplegia
Authors: Alice L. Garrett, Jacquelin Perry, Vernon L. Nickel
Journal: JAMA (1964)

The number of quadriplegics due to spinal cord injury is increasing each year. These patients need not remain in hospital beds. Most of them can become self-sufficient and live at home; many can become gainfully employed. The degree of function possible is dependent on the presence of certain key muscle groups. Wrist extensors are of major importance because prehension is then possible in an otherwise paralyzed hand. The use of orthotic devices to provide hand function and heavy resistance exercises to hypertrophy remaining musculature make the functional goals of these patients much higher than is generally recognized.
Medical Community Ponders Report Calling for Revitalization of Public Health System
Authors: Charles Marwick
Journal: JAMA (1988)

THE LATE Rene Dubos, PhD, in his book The Mirage of Health pointed out that improvements in health during the past century have been due more to public health measures than to wonder drugs. Now, making the rounds of the medical community is a report from the Washington-based Institute of Medicine (which operates under the National Academy of Sciences' congressional charter as a federal advisory agency) that suggests that the nation is forgetting this and its public health system is in a parlous state.  Two-Year Study  A 22-member committee, named by the institute and chaired by Richard D. Remington, PhD, University of Iowa College of Medicine, Iowa City, spent two years on the study. It was undertaken to address a growing perception among those concerned that the nation has lost sight of its public health goals and allowed the system to fall into disarray.  Remington says that we have come
Foreign Medical Graduates
Authors: Stewart B. Fleishman
Journal: JAMA (1979)

To the Editor.—  I think it is an act of omission to disregard again the pool of American-born FMGs who can partially satisfy the demand for house staff members in postgraduate training programs.  Assuming that the education received at foreign medical schools is equivalent for the native of that country and the foreign student (ie, the American studying there), once in postgraduate programs in the United States, the familiarity with our American culture plus fluency in English and occasionally a second language in which he or she studied medicine abroad puts the American-born FMG at an advantage in taking histories and performing physical examinations, two skills Weinstein cited as deficient in foreign-born FMGs.  As stated in Future Recommendations No. 1, it seems that educational support for FMGs can be updated with special emphasis on programs for American-born FMGs, such as the Fifth Pathway. It is time to support our own
197 Inappropriately low angiotensin-converting enzyme (ACE) plasma levels: A factor worsening kidney function and survival rate in subsets of patients with decompensated cirrhosis
Authors: G. Sansoe, S. Silvano, G. Mengozzi, L. Todros, A. Smedile, G. Touscoz, F. Rosina, M. Rizzetto
Journal: Journal of Hepatology (2004)
A Useful Approach to the Differential Diagnosis of Small Polypoid Lesions of the Gallbladder, Utilizing an Endoscopic Ultrasound Scoring System
Authors: Y. Sadamoto, S. Oda, M. Tanaka, N. Harada, H. Kubo, T. Eguchi, H. Nawata
Journal: Endoscopy (2002)

The purpose of this study was to assess the accuracy of endoscopic ultrasonography (EUS) in making a differential diagnosis of small (< or = 20 mm in diameter) polypoid lesions of the gallbladder, and to construct an EUS scoring system.The EUS findings were retrospectively analyzed in 70 surgical cases of small polypoid lesions classified into two groups: neoplastic (adenocarcinoma in 11, and adenoma in 7), and non-neoplastic (cholesterol polyp in 44, inflammatory polyp in 7 and fibrous polyp in 1). The EUS variables were the maximum diameter and height/width ratio of the largest polyps, echo level, internal echo pattern, surface patterns, number and shape of polyps, presence of hyperechoic spotting, complication of gallbladder stones. The EUS data were used for the construction of an EUS scoring system to ascertain the risk of neoplasia.Three EUS variables, i. e. tumor maximum size, internal echo pattern, and hyperechoic spotting were statistically significant according to multivariate analysis using stepwise logistic regression models (P < 0.01, P < 0.05, and P < 0.01, respectively). The total EUS score based on the coefficient of multivariate analysis was as follows: (maximum diameter in mm) + (internal echo pattern score; where heterogeneous = 4, homogeneous = 0) + (hyperechoic spot[s] score; where presence = - 5, absence = 0). According to our EUS scoring system, the sensitivity, specificity, and accuracy for the risk of neoplastic polyps with scores of 12 or higher were 77.8 %, 82.7 % and 82.9 %, respectively.The EUS scoring system will be a useful means of differentiating between neoplastic and non-neoplastic polyps of the gallbladder.
Small Amounts of Gluten in Subjects With Suspected Nonceliac Gluten Sensitivity: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial
Authors: Antonio Di Sabatino, Umberto Volta, Chiara Salvatore, Paolo Biancheri, Giacomo Caio, Roberto De Giorgio, Michele Di Stefano, Gino R. Corazza
Journal: Clinical Gastroenterology and Hepatology (2015)
OT2-07-01: Pasireotide Long Acting Release (LAR) in Breast Cancer Patients To Prevent Lymphocele after Mastectomy and Axillary Node Dissection: A Randomized, Multicenter, Phase II Study.
Authors: E Chereau, C Uzan, C Bezu, C Mazouni, M Ballester, S Gouy, F Rimareix, J-R Garbay, E Daraï, S Uzan, C Coutant, R Rouzier
Journal: Cancer Research (2011)

Abstract Background: Lymphocele is the principal post-operative morbidity following axillary node dissection. According to the literature, incidence can vary from 4 to 89%. Encouraging results in terms of reducing postoperative lymphoceles as well as drainage duration and volume using octreotide have been recorded recently. A new molecule, namely pasireotide, developed by Novartis Pharma AG, Basle Switzerland, is a somatostatin analog possessing high binding affinity to 4 of the 5 somatostatin receptors. Trial design: We are performing a prospective, randomized 1:1, double blind, multicenter trial against placebo with a Bayesian design. Eligibility criteria: any female patient scheduled for breast surgery with mastectomy and axillary node dissection indicated at the pre-surgical stage. Specific aims: The purpose of this trial is to assess the efficacy of a single pre-surgical injection of pasireotide LAR 60 mg im in reducing the postoperative incidence of symptomatic lymphoceles following mastectomy with axillary node dissection for breast cancer. Patients are followed up for 4 weeks Statistical methods: The statistical analysis will be carried out sequentially after observing the principal criterion (i.e. success is defined as a total volume of lymphocele following single or repeated aspiration ≤ 60 cc in the 28 days following surgery or a routine aspiration volume on the 28th day ≤ 120cc) of each patient included for each randomization group, with or without treatment. It involves estimating the probability of a response in each group using a Bayesian design based on a beta-binomial model. With the Bayesian approach, the response rate in each group (πi) is considered as a random variable, with a priori density focused on the anticipated response rate of 80% in the group receiving treatment and 60% in the non-treatment group, which will be sequentially updated as the observations are made according to a so-called a posteriori law. Present accrual and target accrual: The sample size consists of a total of 90 patients with 45 patients in the active treatment group and 45 patients in the placebo one. To date more than 50% of the patients have been included. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr OT2-07-01.
Correction
Authors: R van Furth, A E Gassmann, M M Diesselhoff-Den Dulk
Journal: The Journal of Experimental Medicine (1975)

The present communication concerns the effect of azathioprine on the mitotic activity of promonocytes and the production of monocytes. In vitro and in vivo labeling with [3H]thymidine showed that during azathioprine treatment the promonocytes synthesize DNA and that, contrary to expectation, the labeling index increases. Cytospectrophotometric determination of the Feulgen-DNA content of the promonocytes during azathioprine treatment showed an increase in the percentage of tetraploid promonocytes, and determination of the various phases of the cell cycle showed significantly increased DNA synthesis and cell cycle times as compared with the normal steady state. On the basis of these results it can be concluded that azathioprine arrests the cell cycle of the promonocytes late in the DNA synthesis phase or in the postsynthesis (G2) phase and mitosis does not occur. This timing of the effect of azathioprine had not been previously observed. The diminished mitotic activity of the promonocytes during azathioprine treatment depressed monocyte production. During treatment with 3 mg/kg azathioprine the cell cycle time of the promonocytes was on the average 5.5 h longer than in the normal steady state and the rate of monocyte production was reduced by 70%. During an acute inflammatory reaction too, monocyte production is affected by azathioprine. In animals not treated with azathioprine but with an acute inflammation the cell cycle time becomes shorter and the monocyte production increases, but animals treated with (3 mg/kg) azathioprine do not show this effect. The kinetics of the monocyte also changes under the low dosage of azathioprine. As consequence of the diminished production of monocytes, far fewer (about 50%) monocytes enter and leave the circulation than during the normal steady state. During an acute inflammatory reaction the numbers in transit through the circulation are slightly augmented but remain considerably lower than in nonazathioprine-trehat of animals not treated with azathioprine.
Sirtuin expression is decreased in malignant breast tissue and is associated with patient outcome.
Authors: S Zino, N Ashraf, DB Kingsmore, AP Payne, W George, PG Shiels
Journal: Cancer Research (2009)

Abstract Abstract #5073 Background: Age is associated with increased incidence of cancer; therefore exploring factors associated with biological ageing in cancer may improve our understanding of the disease and result in new prognostic markers or therapeutic targets. Sirtuins belong to a family of genes that are involved in cell processes including DNA repair, cell-cycle regulation and ageing. SIRT6 modulates telomeric chromatin, is involved in DNA repair and the suppression of genomic instability, aberrations of which are key features of cancer cells. SIRT7 is a positive regulator of RNA polymerase I (Pol I) transcription. Recently, altered sirtuins expression has been linked with lung cancer, gliomas and thyroid cancer. This study aimed to investigate whether SIRT6 and SIRT7 expression is altered in breast tumour biopsies and to determine any association between sirtuin expression and patient outcome.&amp;#x2028; Materials and Methods: The transcriptional expression of SIRT6 and SIRT7 was determined using real-time PCR in archival breast biopsies (73 non-malignant and 70 malignant). SIRT6 and SIRT7 expression relative to HPRT (house keeping gene) was then analysed with respect to histopathology, disease recurrence and survival.&amp;#x2028; Results: We observed a significant decrease in the relative transcriptional expression of SIRT6 and SIRT7 in breast cancer biopsies (median for SIRT6 = 0.799 and SIRT7= 0.482) when compared with non-malignant tissue (median for SIRT6 = 1.823 and SIRT7= 0.607) (Mann-Whitney test, p &amp;lt;0.001 and p= 0.043 respectively). There was a significant association between SIRT6 expression and tumour grade (Kruskal Wallis Test, p=0.002), whereas only a trend was observed for SIRT7 (Kruskal Wallis Test, p=0.067). Kaplan-Meier survival analysis showed that mean survival was significantly shorter in patients with lower SIRT6 expression when compared with those with higher levels of expression (9.32 years vs 13.06 years, p=0.01). A trend was observed between levels of SIRT7 expression and survival (p=0.083). Furthermore, multivariate Cox-regression analysis revealed that SIRT6 expression was independent of tumour size, grade, nodal status, and oestrogen receptor status as a survival predictor (p =0.036).&amp;#x2028; Discussion: These results demonstrate an association between SIRT6 expression and breast cancer pathogenesis and suggest possible SIRT7 involvement. Decreased SIRT6 expression is consistent with genomic instability associated with tumourigenesis and might indicated telomeric dysfunction. Lower levels of SIRT7 are an indication of increased biological ageing in cancerous cells. Furthermore, the association between SIRT6 and both tumour grade and survival, indicates that SIRT6 might prove to be an additional prognostic marker for breast cancer patients. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 5073.
Evaluation of a New Antihypertensive Agent
Authors: Mary Ellen Kosman
Journal: JAMA (1977)

Prazosin hydrochloride is an orally administered vasodilator that recently became available for the treatment of hypertension. It causes less tachycardia than hydralazine but may produce orthostatic hypotension, particularly after the initial dose. The role of prazosin in therapy is limited because of the risk of a first-dose syncopal reaction, and it appears to be indicated primarily in patients who cannot tolerate hydralazine hydrochloride or sympathetic depressant drugs. Like other antihypertensive agents, prazosin should be given with a diuretic.
ASTHMA AS A RESULT OF NASAL CONDITIONS.
Authors: P. J. H. FARRELL
Journal: JAMA (1901)

The frequency of asthma as a result of a diseased nasal condition has so often been brought to my notice that I feel hopeful of effecting a cure in every case of this distressing malady that consults me. Unfortunately, I am occasionally disappointed, but only in a small minority of my cases. I will not go into the pathology of the disease, but will report the results obtained in selected cases not previously reported. I have found that cases of asthma in children under 10 years of age have, after the removal of the offending adenoids, given the best results. While we, as rhinologists, know what a normal nose ought to be, we are not aware of the exact amount of deviation from the normal which may exist without discomfort in any given case. I find that it is difficult in many cases to know just what is the offending
Commentary: Evaluation of specialist paediatric retrieval teams
Authors: S. Logan
Journal: BMJ (1995)

In 1993 a British Paediatric Association working party concluded that care for critically ill children should be concentrated in paediatric intensive care units.1 This report was criticised in a response by the NHS Centre for Reviews and Dissemination for relying too heavily on opinion rather than evidence,2 but two independent reviews commissioned by the centre,2 while critical of some recommendations, did agree on the need for the most severely ill children to be cared for in dedicated paediatric intensive care units. Despite a lack of randomised controlled trials it seems likely that the weight of professional and public opinion will drive the …
US Military Medical Teams Begin Third Year of United Nations Support in War-Torn Balkans
Authors: Phil Gunby
Journal: JAMA (1994)

TOMORROW marks the beginning of the third year for US military medicine's operation of the United Nations (UN) hospital in the former republic of Yugoslavia. It was November 10, 1992, when an advance team of medical and support personnel from the 212th Mobile (US) Army Surgical Hospital (MASH) arrived in Zagreb, Croatia, from Germany to set up the facility at Camp Pleso near the city's airport to care for UN peacekeepers. The 502nd MASH, also from US Army posts in Germany, Belgium, and Italy, succeeded the 212th MASH 6 months later. The US Air Force's 48th Medical Group Hospital from RAF (Royal Air Force base) Lakenheath, England, then operated the Zagreb facility from September 1993 until the US Navy's Fleet Hospital 6 took over March 17 (<i>JAMA</i>. 1994;271:894). Another US Navy mobile medical unit, Fleet Hospital 5, arrived 11 weeks ago and will operate the UN facility until mid-February 1995.
Acute Organic Brain Syndrome Associated With Gentamicin Therapy
Authors: Gary J. Byrd
Journal: JAMA (1977)

Two patients receiving gentamicin sulfate experienced acute organic brain syndromes that subsided after use of the drug was discontinued. Among the various factors considered as possible causes, time sequences point to gentamicin as the most likely. (<i>JAMA</i>238:53-54, 1977)
Brucellosis, a Possible Cause of Hydrarthrosis
Authors: Harold J. Harris
Journal: JAMA (1961)

To the Editor:—  InThe Journal, Jan. 14, there is a question and answer on hydrarthrosis, and brucellosis, a known possible cause of hydrarthrosis, was not mentioned.  In some casesBrucellahas been isolated from the synovial fluid. In others the fluid has been sterile but the effusion has yielded to treatment of the brucellosis (Harris, H. J.:Brucellosis [Undu-lant Fever]—Clinical and Subclinical, ed. 2, New York: Paul B. Hoeber, Inc., 1950, pp. 214-216). Hydrarthrosis often occurs, after only trivial injury to the joints in patients suffering from chronic, low-grade brucellosis.  In attempting to establish the diagnosis of brucellosis, all available tests should be used. One should not rely on the agglutination test alone unless it is positive in high titer. About 50 per cent of cases of chronic brucellosis show no agglutinins or agglutinins in low titer only. In these instances one must depend on additional information furnished
Former director of mental health trust is struck off for unacceptable behaviour
Authors: C. Dyer
Journal: BMJ (2010)

A former consultant psychiatrist who examined the breasts of two vulnerable patients, subjected trainees to sexual innuendoes, and was convicted of child pornography offences has been struck off for behaviour “utterly incompatible with being a doctor.”

Andrew Clayton made the “outrageous” suggestion that he should suck a patient’s nipples after she said that she was worried that, because they were inverted, she may have difficulty breast feeding, a General Medical Council fitness to practise panel found.

He asked a preregistration house …
Voice Analysis and Behavior Pattern
Authors: Meyer Friedman
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Dr. Johnson's letter seems to us to illustrate that which sometimes occurs when an individual adept in statistical methods peruses a research publication. Namely, that in his preoccupation with the numerals of a paper, he overlooks or misinterprets the verbal and creative content. Thus, Dr. Johnson erroneously concluding that the behavior pattern of six of our 19 type A subjects was known to the examiner, eliminates these six and employs the remaining 13 for his statistical scrutiny. However, had he read the paper carefully he would have discovered that the behavior pattern of not six but 13 of the 19 type A subjects was known to us. As a result of this, even his meticulous estimation of the confidence limits of our assessment makes this initial error of his a more glaring one. It is difficult for us also to understand why Dr. Johnson seemingly overlooked the