tbuckley/cabot-search huggingface dataset:
Salicylate or Aspirin Inhibits the Induction of the Inducible Nitric Oxide Synthase in Rat Cardiac Fibroblasts
Authors: R. Saeid Farivar, Aram V. Chobanian, Peter Brecher
Journal: Circulation Research (1996)

Abstract To determine if fibroblasts are a source of NO in inflammatory myocardial diseases, we have studied the effect of cytokines on the inducible NO synthase (iNOS) in neonatal cardiac fibroblasts and tested whether nonsteroidal anti-inflammatory drugs can diminish the induction of iNOS. In primary cultures, interferon gamma (IFN), interleukin-1β (IL-1), or tumor necrosis factor-α (TNF) separately did not stimulate nitrite production, whereas IFN combined with IL-1 or TNF synergistically induced iNOS, both at the level of steady state mRNA and nitrite accumulation. Steady state mRNA levels for iNOS were obvious as early as 3 hours after the addition of IFN+TNF and remained elevated for at least 72 hours. Sodium salicylate inhibited cytokine-induced nitrite accumulation in a time- and dose-dependent manner (IC 50 , 750 μmol/L). The inhibition was reversible and occurred when salicylate was added either before or after cytokine induction. Aspirin (1 mmol/L) also inhibited nitrite production, whereas indomethacin (25 μmol/L) or acetaminophen (100 μmol/L) did not. TNF, either alone or combined with IFN, significantly stimulated prostaglandin E 2 , which was inhibited by either salicylate (4 mmol/L) or indomethacin (25 μmol/L). Salicylate, when given either before or after IFN+TNF, reduced mRNA levels of iNOS induced by cytokines. Salicylate did not affect iNOS enzymatic activity when added to the cytosolic lysate, although it was able to reduce enzymatic activity to 32% of induced levels when given to intact cells. These studies implicate cardiac fibroblasts as a source of NO in inflammatory cardiac diseases and suggest a possible therapeutic role for salicylate and aspirin in diminishing the steady state levels of iNOS mRNA.
The impact of experience on polyp detection and sizing accuracy at capsule endoscopy: implications for training from an animal model study
Authors: A. Postgate, P. Tekkis, A. Fitzpatrick, P. Bassett, C. Fraser
Journal: Endoscopy (2008)

See also: Commentaire de travail de A. Postgate et al., pp. 496Endoscopy 2008; 40(06): 545-545DOI: 10.1055/s-0032-1306844
HEMICRANIOSIS AND CURE OF BRAIN TUMOR BY OPERATION.
Authors: WILLIAM G. SPILLER
Journal: JAMA (1907)

Under the name of<i>hemicraniose</i>Brissaud and Lereboullet<sup>1</sup>describe a condition observed by them in two cases—a hypertrophy localized exclusively to a half of the cranium including the face. The first patient had epileptic convulsions. The enlargement of the head was first noticed about the age of two months, and it was slowly progressive and without pain. The patient had no headache, although he complained of a sense of heaviness in the head. His vision was good. He had no vomiting. The interesting feature of the case was the frontoparietal exostosis. The prominence did not extend into the occipital region nor beyond the median line. There was also a supraorbital enlargement of bone, but the rest of the face was not affected. This was purely a clinical case. The second patient, a woman, had cranial hemihypertrophy dating from childhood, also signs of brain tumor, the latter of two and a
Effects of truncal, selective, and highly selective vagotomy on glucose tolerance and insulin secretion in patients with duodenal ulcer. Part II-Comparison of response to oral and intravenous glucose.
Authors: C S Humphrey, J R Dykes, D Johnston
Journal: BMJ (1975)

Paired oral and intravenous glucose tolerance tests were carried out in patients who had undergone truncal vagotomy and pyloroplasty, selective vagotomy and pyloroplasty, or highly selective vagotomy at least six months earlier. Intravenous glucose tolerance was similar in all three groups. Oral glucose elicited significantly higher concentrations of plasma insulin in patients who had undergone selective and highly selective vagotomy than in those treated by truncal vagotomy. When the same amount of glucose was given intravenously, however, plasma insulin concentrations were similar in all three groups of patients. The insulin secreted in response to intravenous glucose expressed as a percentage of that secreted in response to oral glucose was 112% for truncal vagotomy, 51% for selective vagotomy, and 52% for highly selective vagotomy. Truncal vagotomy thus led to a diminished insulin response to oral glucose, which was probably due to impaired release of small-bowel hormones.
The Role of Catecholamines in the Free Fatty Acid Response to Cigarette Smoking
Authors: ALFRED KERSHBAUM, ROSTAM KHORSANDIAN, RAYMOND F. CAPLAN, SAMUEL BELLET, LEONARD J. FEINBERG
Journal: Circulation (1963)

The role of the adrenal glands and the sympathetic nervous system in the free fatty acid (FFA) rise after smoking was investigated. In 11 subjects who smoked three cigarettes per hour for a 3-hour period, urinary free catecholamine excretion increased 2.5 µg./hr. (21 per cent) and total catecholamine excretion increased 3.1 µg./hr. (16 per cent). FFA elevations occurred in all subjects during the smoking period. In three subjects, repeated control determinations of their FFA response to smoking were made and a rise was observed in each instance. Sympathetic ganglionic blockade was then induced with methaphan camphorsulfonate and the smoking tests were repeated. No rise in FFA after smoking occurred following blockade. Eight patients, who had previously undergone bilateral adrenalectomy for the treatment of hypertension, were studied for their FFA response to smoking. In six subjects there was no significant elevation. In two subjects there was a minimal effect. These findings indicate that for cigarette smoking to cause an increase in serum free fatty acids both the adrenal glands and the sympathetic nervous system must be functioning, probably to produce an effective level of circulating catecholamines.
Antiangiogenic Properties of Gold Nanoparticles
Authors: Priyabrata Mukherjee, Resham Bhattacharya, Ping Wang, Ling Wang, Sujit Basu, Janice A. Nagy, Anthony Atala, Debabrata Mukhopadhyay, Shay Soker
Journal: Clinical Cancer Research (2005)

Abstract Here, we report an intrinsic property of gold nanoparticles (nanogold): they can interact selectively with heparin-binding glycoproteins and inhibit their activity. Gold nanoparticles specifically bound vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-165 and basic fibroblast growth factor, two endothelial cell mitogens and mediators of angiogenesis resulting in inhibition of endothelial/fibroblast cell proliferation in vitro and VEGF-induced permeability as well as angiogenesis in vivo. In contrast, nanogold did not inhibit VEGF-121 or epidermal growth factor, two non–heparin-binding growth factors, mediated cell proliferation. Gold nanoparticles significantly inhibited VEGF receptor-2 phosphorylation, intracellular calcium release, and migration and RhoA activation in vitro. These results report for the first time a novel property of gold nanoparticles to bind heparin-binding proteins and thereby inhibit their subsequent signaling events.
Iliac vein compression.--Its relation to iliofemoral thrombosis and the post-thrombotic syndrome.
Authors: F. B. Cockett, M. L. Thomas, D. Negus
Journal: BMJ (1967)

Summary The treatment of haemorrhoids by conservative methods has been examined. Injection therapy with the use of phenol in almond oil was effective in controlling bleeding, but with almond oil alone it was not. A comparison between the results of injection therapy and the technique of rubber ring ligation showed objectively better results after six months with ligations. However, ligation was sometimes followed by pain, and a few patients refused to continue with this form of treatment. These preliminary alternatives indicate that phenol in oil is still the best treatment for early first-degree piles. The results of ligation for second-degree piles are encouraging, but further evaluation is required.
CBT by telephone for depression improved adherence compared with face-to-face CBT in primary care
Authors: Rodger Kessler
Journal: Annals of Internal Medicine (2012)

Source Citation Mohr DC, Ho J, Duffecy J, et al. Effect of telephone-administered vs face-to-face cognitive behavioral therapy on adherence to therapy and depression outcomes among primary care patients: a randomized trial. JAMA. 2012;307:2278-85. 22706833
MEDICAL SOCIETY OF THE COUNTY OF NEW YORK
Authors: Brooks H. Wells
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Costs of the Metabolic Syndrome in Elderly Individuals
Authors: Lesley H. Curtis, Bradley G. Hammill, M. Angelyn Bethel, Kevin J. Anstrom, John S. Gottdiener, Kevin A. Schulman
Journal: Diabetes Care (2007)

OBJECTIVE—The cardiovascular consequences of the metabolic syndrome and its component risk factors have been documented in elderly individuals. Little is known about how the metabolic syndrome and its individual components translate into long-term medical costs. RESEARCH DESIGN AND METHODS—We used log-linear regression models to assess the independent contributions of the metabolic syndrome and its individual components to 10-year medical costs among 3,789 individuals aged ≥65 years in the Cardiovascular Health Study. RESULTS—As defined by the National Cholesterol Education Program Third Adult Treatment Panel report, the metabolic syndrome was present in 47% of the sample. Total costs to Medicare were 20% higher among participants with the metabolic syndrome ($40,873 vs. $33,010; P &amp;lt; 0.001). Controlling for age, sex, race/ethnicity, and other covariates, we found that abdominal obesity, low HDL cholesterol, and elevated blood pressure were associated with 15% (95% CI 4.3–26.7), 16% (1.7–31.8), and 20% (10.1–31.7) higher costs, respectively. When added to the model, the metabolic syndrome composite variable did not contribute significantly (P = 0.32). CONCLUSIONS—Abdominal obesity, low HDL cholesterol, and hypertension but not the metabolic syndrome per se are important predictors of long-term costs in the Medicare population.
A mannose receptor mediates mannosyl-rich glycoprotein-induced mitogenesis in bovine airway smooth muscle cells.
Authors: D B Lew, E Songu-Mize, S E Pontow, P D Stahl, M C Rattazzi
Journal: Journal of Clinical Investigation (1994)

The putative mannose receptor (MR), previously implicated in mannosyl-rich glycoprotein-induced mitogenesis in bovine airway smooth muscle (ASM) cells, was studied to determine its properties. Specific binding of the mitogenic neoglycoprotein, mannosylated bovine serum albumin (Man-BSA) to ASM cells was saturable, with an apparent Kd = 5.0 x 10(-8) M. Cell-bound ManBSA-colloidal gold conjugate was localized by electron microscopy to clathrin-coated pits on the cell surface, and was found to undergo internalization to endosomes; this was inhibitable by weak bases and swainsonine, that also inhibited ligand-induced mitogenesis. The ASM-MR, isolated by mannose-affinity chromatography, had the same apparent molecular mass as the macrophage (Mø) MR (M(r) = 175 kD), and was immunoprecipitated by an anti-MøMR immune serum. This antiserum blocked 125I-labeled-ManBSA binding to intact ASM cells, stimulated mitogenesis, and immunolocalized the ASM-MR in cytoplasmic vesicles compatible with endosomes. A monoclonal antibody directed against the MøMR also reacted with the ASM-MR; like the polyclonal antibodies, it stimulated mitogenesis as effectively as beta-hexosaminidases. These data indicate that the ASM-MR shares a number of functional and structural properties with the MøMR and suggest that similar receptors may have different main functions in different cells.
Lumbar epidural analgesia in labour: relation to fetal malposition and instrumental delivery.
Authors: I J Hoult, A H MacLennan, L E Carrie
Journal: BMJ (1977)

The incidence of instrumental delivery and malposition immediately before delivery was compared in patients who were given lumbar epidural analgesia and those who were not. Instrumental delivery was five times more common and a malposition of the fetal head was more than three times as common in the epidural group as in women who did not receive regional analgesia. Similar incidences were found even when the epidural was electively chosen before labour in the absence of medical indications. The instrumental delivery rate was affected by parity, the length of the second stage of labour, and the return of sensation by the second stage but not by other factors studied. The high incidence (20%) of malposition associated with epidural analgesia was not affected by any of the factors studied. The psychological and physical disadvantages of malposition and instrumental delivery have yet to be assessed. In the meantime, when there are no medical indications for epidural analgesia, the advantages of pain relief should be weighed against those of a normal spontaneous delivery.
(59) Chronic cheilitis? Crohn's disease
Authors: D.M. Williamson
Journal: British Journal of Dermatology (1987)

Journal Article (59) Chronic cheilitis? Crohn's disease Get access D.M. Williamson D.M. Williamson Pontefract General Infirmary Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue s32, 1 June 1987, Pages 116–117, https://doi.org/10.1111/j.1365-2133.1987.tb12099.x Published: 01 June 1987
Risk-factors for emerging bloodstream infections caused by extended-spectrum β-lactamase-producing Escherichia coli
Authors: J. Rodríguez-Baño, M.D. Navarro, L. Romero, M.A. Muniain, M. de Cueto, J. Gálvez, E.J. Perea, A. Pascual
Journal: Clinical Microbiology and Infection (2007)
Review: Evidence on the effectiveness of sodium bicarbonate regimens to prevent contrast-induced nephropathy is unclear
Authors: Amit X Garg
Journal: Annals of Internal Medicine (2010)

Source Citation Zoungas S, Ninomiya T, Huxley R, et al. Systematic review: sodium bicarbonate treatment regimens for the prevention of contrast-induced nephropathy. Ann Intern Med. 2009;151:631-8. 19884624
Primary NK-/T-cell lymphoma of the gastrointestinal tract: clinical characteristics and endoscopic findings
Authors: J. Kim, J. Lee, J. Lee, S.-O. Oh, D. Chang, P.-L. Rhee, J. Kim, J. Rhee, J. Lee, W. Kim, Y. Ko
Journal: Endoscopy (2007)

Primary NK-/T-cell lymphoma of the gastrointestinal tract is a very rare disease with a poor prognosis. The aim of this study was to determine the clinical and endoscopic characteristics of patients with primary gastrointestinal NK-/T-cell lymphoma.The clinical features of 14 patients with primary gastrointestinal NK-/T-cell lymphoma and the endoscopic findings in 11 of these patients were reviewed. Their median age was 42 years (range 23-78) at the time of diagnosis.The initial presenting symptoms of primary gastrointestinal NK-/T-cell lymphoma were gastrointestinal bleeding (n = 6, 42%), abdominal pain (n = 4, 29%), and epigastric soreness (n = 4, 29%). The disease was at an advanced stage at the time of diagnosis: stage II in 5 patients (36%); stage III in 4 (28%); and stage IV in 5 (36%). Initial treatment was with chemotherapy (n = 8, 57%) or surgical resection (n = 5, 36%). The median survival for all patients was 9 months. On endoscopy in 11 patients, the anatomic location of the primary lesion was found to be: stomach, n = 3 (27%); esophagus, n = 2 (18%); duodenum, n = 1 (9%); and the ileocolonic area, n = 5 (46%). These lesions were ulceroinfiltrative in 4 cases (36%), ulcerative in 3 cases (27%), superficial/erosive in 3 cases (27%), and infiltrative in 1 case (9%). No prominent fungating mass was seen in any patient.Primary gastrointestinal NK-/T-cell lymphoma was endoscopically characterized by superficial/erosive, ulcerative, or ulceroinfiltrative lesions without fungating mass. The most common presenting symptom was gastrointestinal bleeding. Despite aggressive treatments, the prognosis was very poor.
597. Liver Tissue Engineering at Extra-Hepatic Site: A Novel Therapeutic Approach toward Hemophilia
Authors: Kazuo Ohashi, Mark A. Kay, Takashi Yokoyama, Hiroyuki Kuge, Hiromichi Kanehiro, Michiyoshi Hisanaga, Saiho Ko, Hiroyuki Naka, Akira Yoshioka, Yoshiyuki Nakajima
Journal: Molecular Therapy (2005)
Recurrent PTPRB and PLCG1 mutations in angiosarcoma
Authors: Sam Behjati, Patrick S Tarpey, Helen Sheldon, Inigo Martincorena, Peter Van Loo, Gunes Gundem, David C Wedge, Manasa Ramakrishna, Susanna L Cooke, Nischalan Pillay, Hans Kristian M Vollan, Elli Papaemmanuil, Hans Koss, Tom D Bunney, Claire Hardy, Olivia R Joseph, Sancha Martin, Laura Mudie, Adam Butler, Jon W Teague, Meena Patil, Graham Steers, Yu Cao, Curtis Gumbs, Davis Ingram, Alexander J Lazar, Latasha Little, Harshad Mahadeshwar, Alexei Protopopov, Ghadah A Al Sannaa, Sahil Seth, Xingzhi Song, Jiabin Tang, Jianhua Zhang, Vinod Ravi, Keila E Torres, Bhavisha Khatri, Dina Halai, Ioannis Roxanis, Daniel Baumhoer, Roberto Tirabosco, M Fernanda Amary, Chris Boshoff, Ultan McDermott, Matilda Katan, Michael R Stratton, P Andrew Futreal, Adrienne M Flanagan, Adrian Harris, Peter J Campbell
Journal: Nature Genetics (2014)
HOLES IN THE MESENTERY WITH HERNIATION OF THE INTESTINE.
Authors: G. K. DICKINSON
Journal: JAMA (1907)

These anatomic curiosities, due to defect of development or subsequent alteration in structure, seem to attract little attention; nevertheless, they are of scientific interest. Holes in the mesentery are apparently of great infrequency and with few exceptions no references to them are found in the literature nor attempts to explain their origin. In the mesogastrium (the omentum) they are not infrequent. It is probable that the same conditions which cause them in the omentum lead to their formation in the mesentery. They are seldom found in the upper part; the nearer the cecum the more numerous and the larger they become. Traumatism with laceration, the breaking down of caseous glands, and emptying of serous or chylous cysts may give origin to them, but the most frequent situation for their location being proximal to the cecum, suggests defective arterial supply and gradual absorption as the more logical explanation for their existence.
Long-term Effects of Work Cessation on Respiratory Health of Textile Workers
Authors: Jing Shi, Jing-qing Hang, Amar J. Mehta, Hong-xi Zhang, He-lian Dai, Li Su, Ellen A. Eisen, David C. Christiani
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

The degree to which chronic respiratory health effects caused by exposures to cotton dust and endotoxin is reversible after cessation of textile work is unknown.To investigate changes in lung function and respiratory symptoms after cessation of textile work and to determine whether past exposure to cotton dust and endotoxin or smoking history modify the associations.We performed a prospective cohort study consisting of 447 cotton textile workers exposed to cotton dust and 472 unexposed silk textile workers, with a 25-year follow-up. Spirometry testing and respiratory questionnaires were conducted at 5-year intervals. Generalized estimated equations were used to model the average 5-year change in FEV(1) and odds ratios of respiratory symptom prevalence.Years since cessation of textile work was positively associated with 11.3 ml/yr and 5.6 ml/yr gains in 5-year FEV(1) change for cotton and silk workers, respectively. Among male cotton workers, smokers gained more FEV(1) per year after cessation of exposure than did nonsmokers, and the risk of symptoms of chronic bronchitis and byssinosis was larger for smoking than for nonsmoking male cotton workers.Cessation of textile work was significantly associated with improvement in lung function and respiratory symptoms. The positive effect of work cessation was greater for cotton workers than for silk workers. For cotton workers, the improvement in lung function loss after cessation of textile work was greater among smokers, but no differences were observed for silk workers.
Tubular and Glomerular Kidney Effects in Swedish Women with Low Environmental Cadmium Exposure
Authors: Agneta Åkesson, Thomas Lundh, Marie Vahter, Per Bjellerup, Jonas Lidfeldt, Christina Nerbrand, Göran Samsioe, Ulf Strömberg, Staffan Skerfving
Journal: Environmental Health Perspectives (2005)

Cadmium is a well-known nephrotoxic agent in food and tobacco, but the exposure level that is critical for kidney effects in the general population is not defined. Within a population-based women's health survey in southern Sweden (Women's Health in the Lund Area, WHILA), we investigated cadmium exposure in relation to tubular and glomerular function, from 1999 through early 2000 in 820 women (71% participation rate) 53-64 years of age. Multiple linear regression showed cadmium in blood (median, 0.38 microg/L) and urine (0.52 microg/L; density adjusted = 0.67 microg/g creatinine) to be significantly associated with effects on renal tubules (as indicated by increased levels of human complex-forming protein and N-acetyl-beta-D-glucosaminidase in urine), after adjusting for age, body mass index, blood lead, diabetes, hypertension, and regular use of nephrotoxic drugs. The associations remained significant even at the low exposure in women who had never smoked. We also found associations with markers of glomerular effects: glomerular filtration rate and creatinine clearance. Significant effects were seen already at a mean urinary cadmium level of 0.6 microg/L (0.8 microg/g creatinine). Cadmium potentiated diabetes-induced effects on kidney. In conclusion, tubular renal effects occurred at lower cadmium levels than previously demonstrated, and more important, glomerular effects were also observed. Although the effects were small, they may represent early signs of adverse effects, affecting large segments of the population. Subjects with diabetes seem to be at increased risk.
Studies on the influence of dietary cholesterol on cholesterol metabolism in the isotopic steady state in man.
Authors: J D Wilson, C A Lindsey
Journal: Journal of Clinical Investigation (1965)

it can quantitatively account only for a degree of protection equal to that amount ordinarily syn- thesized in the liver, whereas the serum cholesterol remains virtually stable despite the in- gestion of quantities of cholesterol many times this value.Second, the ingestion of cholesterol could cause an increase in the rate of degradation of cholesterol to bile acids.This phenomenon