Alpha_1-Antitrypsin Deficiency in Chronic Obstructive Pulmonary Disease
Authors: GEORGE A. FALK
Journal: Annals of Internal Medicine (1970)

Editorials1 March 1970Alpha1-Antitrypsin Deficiency in Chronic Obstructive Pulmonary DiseaseGEORGE A. FALK, M.D., WILLIAM A. BRISOCE, M.D.GEORGE A. FALK, M.D.Search for more papers by this author, WILLIAM A. BRISOCE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-3-427 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIs alpha1-antitrypsin deficiency an etiologic culprit or an innocent genetic bystander in chronic obstructive pulmonary disease? Any consideration of the cause of chronic obstructive pulmonary disease (chronic bronchitis and emphysema) must deal with the variation in clinical and pathological features within this closely interrelated group of illnesses. At one end of the spectrum of clinical pictures is the so-called type A or emphysematous patient (1, 2), typically a thin man who suffers for several years from slowly progressive dyspnea without much cough or sputum production. The lungs are large and radiologically hyperlucent. Despite the severity and chronicity of the dyspnea,...References1. NASHBRISCOECOURNAND EWA: The relationship between clinical and physiological findings in chronic obstructive disease of the lungs. Med Thorac 22:305-327, 1965 MedlineGoogle Scholar2. BURROWSFLETCHERHEARD BCB: The emphysematous and bronchial types of chronic airways obstruction. Lancet 1:830-835, 1966 CrossrefMedlineGoogle Scholar3. GAENSLERLINDGREN EI: Chronic bronchitis as an etiologic factor in obstructive emphysema. Preliminary report. Amer Rev Resp Dis 80:185-193, 1959 MedlineGoogle Scholar4. FLETCHERJONESBURROWS CNB: American emphysema and British bronchitis. Amer Rev Resp Dis 90:1-13, 1964 MedlineGoogle Scholar5. 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Amer J Med 45:220-228, 1968 CrossrefMedlineGoogle Scholar23. HEPPERBLACKGLEICH NLG: The prevalence of alpha1-antitrypsin deficiency in selected groups of patients with chronic obstructive lung disease. Mayo Clin Proc 44: 697-710, 1969 MedlineGoogle Scholar24. ERIKSSON S: Studies in α1-antitrypsin deficiency. Acta Med Scand 432 (suppl): 1-85, 1965 Google Scholar25. MITCHELLFILLEY RG: Chronic obstructive bronchopulmonary disease. I. Clinical features. Amer Rev Resp Dis 89:360-371, 1964 MedlineGoogle Scholar26. TALAMOBLENNERHASSETTAUSTIN RJK: Familial emphysema and alpha1-antitrypsin deficiency. New Eng J Med 275:1301-1304, 1966 CrossrefMedlineGoogle Scholar27. KOWALYSHYNSATALINE TL: Familial emphysema associated with antitrypsin deficiency. Dis Chest 55:285-289, 1969 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The New York Hospital-Cornell University Medical College New York, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEpidemiologie und Bedeutung tabakassoziierter Lungenkrankheiten1. 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