Treatment of Hypercholesterolemia in the Elderly
Authors: Stephanie D. Kafonek
Journal: Annals of Internal Medicine (1990)

Editorials15 May 1990Treatment of Hypercholesterolemia in the ElderlyStephanie D. Kafonek, MD, Peter O. Kwiterovich, MDStephanie D. Kafonek, MDSearch for more papers by this author, Peter O. Kwiterovich, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-10-723 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe major cause of death in elderly persons is atherosclerotic cardiovascular disease (1). This is not a phenomenon of normal human aging, but rather, a disease manifestation of extended cumulative exposure to conventional and unconventional risk factors. Most of the risk factors that predict coronary heart disease (CHD) in middle-aged persons also predict CHD in older persons (2).The causal relationship between elevated total plasma cholesterol concentrations and CHD has been well established in middle-aged persons (3, 4). Analyses of data from prospective population studies have shown that this relationship also holds for persons aged 60 years and older (5-10)....References1. The ten leading causes of death for selected countries in North America, Europe and Oceania, 1969, 1970 and 1971. World Health Stat Rep. 1974;27:563. Google Scholar2. GordonCastelliHjortlandKannelDawber TWMWT. Predicting coronary heart disease in middle-aged and older persons. The Framingham Study. JAMA. 1977;238:497-9. CrossrefMedlineGoogle Scholar3. FrickEloHaapa MOK. Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. N Engl J Med. 1987;317:1237-45. CrossrefMedlineGoogle Scholar4. The Lipid Research Clinics Coronary Primary Prevention Trial Results. I. Reduction in incidence of coronary heart disease. JAMA. 1984;251:351-64. CrossrefMedlineGoogle Scholar5. CastelliWilsonLevyAnderson WPDK. Cardiovascular risk factors in the elderly. Am J Cardiol. 1989;63:12H-9H. 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Reduction of plasma cholesterol levels in normal men on an American Heart Association Step I Diet or a Step I diet with added monounsaturated fat. N Engl J Med. 1990;322:574-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Johns Hopkins University Lipid Clinic Baltimore, MD 21205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrevention of coronary heart diseaseDrug Treatment of Hyperlipidemia in the Elderly: Hmg-Coa Reductase Inhibitors and Fibric Acid DerivativesCLINICAL DECISIONS: An Abnormal Exercise Treadmill Test in an Asymptomatic Older PatientEfficacy and safety of fluvastatin in elderly hypercholesterolemic patients: A pilot studyPhysical Activity and Serum Lipids and Lipoproteins in Elderly WomenTherapie von FettstoffwechselstörungenCardiovascular Risk Factors in Older IndividualsDemographics of the prevalence, incidence, and management of coronary heart disease in the elderly and in womenHypercholesterolemia predicts early death from coronary heart disease in elderly men but not women the Rancho Bernardo StudyClinical considerations regarding treatment of hypercholesterolemia in the elderlyA cholesterol screening and education program: Differences between older and younger adultsShould Hypercholesterolemia in Elderly Persons Be Treated?Robert S. Bernstein, MD 15 May 1990Volume 112, Issue 10Page: 723-725KeywordsAtherosclerotic cardiovascular diseaseAttentionBlood plasmaCongenital heart diseaseCoronary heart diseaseElderlyHypercholesterolemiaLipidsMedical risk factorsProspective studies Issue Published: 15 May 1990 PDF downloadLoading ...