tbuckley/cabot-search huggingface dataset:
Access to Experimental Drugs for Terminally Ill Patients
Authors: Benjamin P. Falit
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Emotional Health of Physicians
Authors: JOHN C. DUFFY
Journal: Annals of Internal Medicine (1968)

Editorials1 December 1968The Emotional Health of PhysiciansJOHN C. DUFFY, M.D.JOHN C. DUFFY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-6-1319 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEmotional illness in physicians has become an issue of growing interest in the past few years. With a candor not found in any other professional group, physicians have painfully explored the impact of emotional illness, not only on their personal lives, but also on their professional ability and responsibilities (1-3). Emotional illness is a serious problem for the physician, as indeed it is for all persons, but by the very nature of his responsibilities the consequences of his mental illness impinge upon the commonweal of society.Most of the studies on the emotional health of physicians have been concerned with...References1. DUFFYLITIN JCEM: Psychiatric morbidity of physicians. JAMA 189: 989, 1964. CrossrefMedlineGoogle Scholar2. DE SOLEAARONSONSINGER DESP: Suicide and role strain among physicians. Presented at the American Psychiatric Association Meeting, Detroit, May 1967. Google Scholar3. DUFFYLITIN JCEM: The Emotional Health of Physicians, Charles C Thomas, Publishers, Springfield, Ill., 1967. Google Scholar4. SMALLSMALLASSUE IFJGCM: The fate of the mentally ill physician. Presented at the American Psychiatric Association Meeting, Boston, May 1968. Google Scholar5. SIMONLUMRY WG: Suicide among physician-patients. J. Nerv. Ment. Dis. 147: 105, 1968. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN C. DUFFY, M.D.Affiliations: University of Minnesota Medical School Minneapolis, Minn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySuicide and the Stress of Residency Training: A Case Report and Review of the LiteratureCoping with Entitlement in Medical EducationFollow-up of sixty-one physicians after psychiatric treatmentPhysicians Treated for Alcoholism: A Follow-Up StudySuicide among PhysiciansMore Notes on Recent ANNALS ThemesE. J. H. 1 December 1968Volume 69, Issue 6Page: 1319-1322KeywordsEmotions ePublished: 1 December 2008 Issue Published: 1 December 1968 PDF downloadLoading ...
Prognostic Value of Preoperative Positron Emission Tomography in Resected Stage I Non-small Cell Lung Cancer
Authors: Boone Goodgame, Giancarlo A. Pillot, Zhiyun Yang, Jabi Shriki, Bryan F. Meyers, Jennifer Zoole, Feng Gao, Farrokh Dehdashti, Alexander Patterson, Barry A. Siegel, Ramaswamy Govindan
Journal: Journal of Thoracic Oncology (2008)
Serum fructosamine versus glycosylated hemoglobin as an index of glycemic control, hospitalization, and infection in diabetic hemodialysis patients
Authors: Neal Mittman, Brinda Desiraju, Irfan Fazil, Hiteshkumar Kapupara, Jyoti Chattopadhyay, Chinu M. Jani, Morrell M. Avram
Journal: Kidney International (2010)
The Flyer Who Fails: An Adult Situational Reaction
Authors: ROGER F. REINHARDT
Journal: American Journal of Psychiatry (1967)

A psychiatric study was made of 46 naval aviators who had demonstrated their mastery of techniques of attack carrier aviation but became unable to continue flying high-performance aircraft. In only a small number of cases was an anxiety reaction or a phobic reaction to flight uncovered. The authors feel that the diagnosis of "adult situational reaction" is applicable to most of these flyers who fail because it emphasizes the difficulty of their task and the absence of serious underlying personality defects.
Development of the murine and human immune system: differential effects of immunotoxicants depend on time of exposure.
Authors: S D Holladay, R J Smialowicz
Journal: Environmental Health Perspectives (2000)

Fetal and early postnatal life represent critical periods in vertebrate immune system development. Disruption of such development by perinatal immunotoxic chemical exposure has been widely described in experimental animal models. The resultant inhibited postnatal immune responses in such animals are often more dramatic and persistent than those after exposure during adult life. Further, recent reports suggest that prenatal exposure to immunotoxicants may exacerbate postnatal aberrant immune responses (e.g., hypersensitivity disorders and autoimmune disease) in genetically predisposed rodents. Limited information is available regarding the possibility of inhibited postnatal immune capacity in humans as a result of developmental immunotoxicant exposure. The multifactorial nature of hypersensitivity and autoimmune responses will further complicate the elucidation of possible relationships between chemical exposure during ontogeny of the human immune system and immune-mediated disease later in life. Taken together, however, the available animal data suggest the potential for altered postnatal immune function in humans exposed to immunotoxicants (e.g., environmental chemicals and therapeutic agents) during fetal and/or early postnatal life.
Steroid hormone action in eucaryotic cells.
Authors: B W O'Malley
Journal: Journal of Clinical Investigation (1984)

O v ver the past decade, work from many laboratories has led to a generally accepted hypothesis for the primary syn- thetic events that are involved in steroid hormone action.Al- though no universal agreement exists for the specific molecular details, the overall steps in the pathway have been elucidated.Receptors for steroid hormones, initially described by Jensen and Jacob (1), are tissue-specific binding proteins for steroidal
THE RESULTS OF THE SURGICAL TREATMENT OF INFLAMMATION OF THE MASTOID PROCESS.
Authors: EDWARD BRADFORD DENCH
Journal: JAMA (1901)

The subject upon which I wish to speak has been so thoroughly considered during the past few years, it would be manifestly impossible for me to give more than my own personal experience in regard to it. What I wish particularly to emphasize, however, is the advisability of early operation in doubtful cases, and to show by my own statistics that the procedure itself is practically free from danger. At the present time the general surgeon does not hesitate to open the abdominal cavity for diagnostic purposes. In the same way, I believe the otologist is perfectly justified in exploring the mastoid cells, whenever there is the slightest evidence of an inflammatory process. In the vast majority of cases, the signs are so well marked that a diagnosis can be easily made. In some, however, especially in those patients in whom the pneumatic cells of the mastoid are well developed,
Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease
Authors: Lindsay A. Farrer
Journal: JAMA (1997)

<h3>Objective.</h3> —To examine more closely the association between apolipoprotein E (<i>APOE</i>) genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and racial denominations. <h3>Data Sources.</h3> —Forty research teams contributed data on<i>APOE</i>genotype, sex, age at disease onset, and ethnic background for 5930 patients who met criteria for probable or definite AD and 8607 controls without dementia who were recruited from clinical, community, and brain bank sources. <h3>Main Outcome Measures.</h3> —Odds ratios (ORs) and 95% confidence intervals (Cls) for AD, adjusted for age and study and stratified by major ethnic group (Caucasian, African American, Hispanic, and Japanese) and source, were computed for<i>APOE</i>genotypes ∈2/∈2,∈2/∈3,∈2/∈4,∈3/∈4 and ∈4/∈4 relative to the ∈3/∈3 group. The influence of age and sex on the OR for each genotype was assessed using logistic regression procedures. <h3>Results.</h3> —Among Caucasian subjects from clinic- or autopsy-based studies, the risk of AD was significantly increased for people with genotypes ∈2/∈4 (OR=2.6, 95% Cl=1.6-4.0), ∈3/∈4 (OR=3.2, 95% Cl=2.8-3.8), and ∈4/∈4 (OR=14.9, 95% CI=10.8-20.6); whereas, the ORs were decreased for people with genotypes ∈2/∈2 (OR=0.6, 95% Cl=0.2-2.0) and ∈2/∈3 (OR=0.6, 95% Cl=0.5-0.8). The<i>APOE</i>∈4-AD association was weaker among African Americans and Hispanics, but there was significant heterogeneity in ORs among studies of African Americans (<i>P</i>&lt;.03). The<i>APOE</i>∈4—AD association in Japanese subjects was stronger than in Caucasian subjects (∈3/∈4: OR=5.6, 95% Cl=3.9-8.0; ∈4/∈4: OR=33.1, 95% Cl=13.6-80.5). The ∈2/∈3 genotype appears equally protective across ethnic groups. We also found that among Caucasians,<i>APOE</i>genotype distributions are similar in groups of patients with AD whose diagnoses were determined clinically or by autopsy. In addition, we found that the<i>APOE</i>∈4 effect is evident at all ages between 40 and 90 years but diminishes after age 70 years and that the risk of AD associated with a given genotype varies with sex. <h3>Conclusions.</h3> —The<i>APOE</i>∈4 allele represents a major risk factor for AD in all ethnic groups studied, across all ages between 40 and 90 years, and in both men and women. The association between<i>APOE</i>∈4 and AD in African Americans requires clarification, and the attenuated effect of<i>APOE</i>∈4 in Hispanics should be investigated further.
Bronchopulmonary Dysplasia in Adulthood
Authors: Mary Ellen B. Wohl
Journal: New England Journal of Medicine (1990)

The development of techniques for the mechanical ventilation of patients with respiratory failure must count as one of the major advances in medical therapy in the past 40 years. During the 1960s, knowledge about how the lung works was translated into improved forms of technology for ventilatory support of patients with lung disease. By the end of that decade, these techniques had been applied to infants; newborn intensive care units were established, in large part to care for prematurely born infants with hyaline membrane disease or respiratory distress syndrome. Pulmonary surfactant had been described,1 and the association between a lack . . .
The Consequences of a Fraudulent Scientist on His Innocent Coinvestigators-Reply
Authors: Drummond Rennie
Journal: JAMA (1990)

In Reply.—  We disagree with Wysocki and Fuqua's letter suggesting that our citation study of 20 cited publications by Dr Stephen E. Breuning in any way implied, intimated, or otherwise indicated that every one was fraudulent. We also disagree with their claim that the study in any way impugned the scientific integrity of the coauthors of these articles.  The publications that we studied were clearly and consistently referred to simply as cited publications by Breuning. No mention of any coauthors was made, nor were any valuations attached to these publications. The exceptions were three articles identified in Table 1 as having been formally retracted by their respective journals by the end of 1988.  The study purposefully did not draw these distinctions because the goal was to indicate the overall influence of Breuning's work—good, bad, or indifferent. A related purpose was to determine what overall effect public disclosure of Breuning's
IMPACT OF THE BETA-1 ADRENERGIC RECEPTOR POLYMORPHISM ON EFFICACY AND TOLERABILITY OF BETA BLOCKER THERAPY IN HEART FAILURE PATIENTS
Authors: Hae-Young Lee, Wook-Jin Chung, Hee-Kyung Jeon, Hong-Seog Seo, Dong-Ju Choi, Eun-Seok Jeon, Jae-Joong Kim, Joon Han Shin, Seok-Min Kang, Sang Hong Baek
Journal: Journal of the American College of Cardiology (2014)
LEGAL ASPECTS OF SPINAE CONCUSSION.Read in the Section of Medical Jurisprudence, at the Forty-first Annual Meeting of the American Medical Association, at Nashville, Tenn., May, 1890.
Authors: S. V. CLEVENGER
Journal: JAMA (1890)

My paper was announced with the above heading through inadvertance, but it does not matter, as there can be but one scientific consideration of the subject, and whatsoever pertains to the medical features of this derangement necessarily concerns the legal, as a broken head or leg should be nothing else in law than what they are in medicine. There are, however, artificial matters not properly involved in the question of the real existence of injuries of any kind, that burden law books and works on medical jurisprudence. The fact that there may be a preponderance of subjective symptoms in alleged concussion cases does not make such accidents peculiar in a medico-legal sense, for several forms of insanity and many physical ailments, at times, discussed in courts possess this same disadvantage. But turning from those rather hackneyed matters let me present a fresh aspect of the subject in
Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine
Authors: Klaus Kunath, Anke von Harpe, Dagmar Fischer, Holger Petersen, Ulrich Bickel, Karlheinz Voigt, Thomas Kissel
Journal: Journal of Controlled Release (2003)
The Cerebrohepatorenal (Zellweger) Syndrome
Authors: Ann E. Moser, Inderjit Singh, Frank R. Brown, George I. Solish, Richard I. Kelley, Paul J. Benke, Hugo W. Moser
Journal: New England Journal of Medicine (1984)

The cerebrohepatorenal (Zellweger) syndrome is a fatal autosomal recessive disorder manifested in the neonatal period by profound hypotonia, psychomotor retardation, dysmorphic features, and an enlarged liver. In this study we demonstrate fivefold or greater increases of very-long-chain fatty acid levels, particularly hexacosanoic acid (C26:0) and hexacosenoic acid (C26:1), in plasma and cultured skin fibroblasts from 20 patients. Similar findings in cultured amniocytes from 3 of 14 women in whom the fetus was at risk of the Zellweger syndrome permitted prenatal diagnosis. Oxidation of very-long-chain fatty acids, which normally takes place in the peroxisome, was impaired in homogenates of cultured skin fibroblasts and amniocytes. This observation extends the evidence that the Zellweger syndrome belongs to the newly formulated category of peroxisomal disorders. The pattern of excess very-long-chain fatty acids differs from that demonstrated previously in patients with childhood adrenoleukodystrophy. The study of very-long-chain fatty acids provides a convenient method for the early diagnosis and prenatal detection of the Zellweger syndrome. (N Engl J Med 1984; 310: 1141–6.)
A Case of Hemichorea-Hemiballismus Due to Nonketotic Hyperglycemia
Authors: Suja Padmanabhan, Alessandro S. Zagami, Ann M. Poynten
Journal: Diabetes Care (2013)

Nonketotic hyperglycemia is a rare cause of hemichorea-hemiballismus. It is more common among postmenopausal woman and can be the first presentation of diabetes mellitus (1). This case report illustrates the importance of distinguishing this cause from other intracranial pathologies as prompt glycemic control leads to complete resolution of the symptoms and signs.

A 76-year-old female presented to our emergency department following a 24-h history of involuntary right upper- and lower-limb movements. There was no history of stroke or preceding trauma. Her neurological examination was notable for right-sided periodic choreiform and ballistic movements, which improved during sleep. Initial biochemistry revealed a blood glucose of 24.4 mmol/L (439.6 mg/dL), normal venous pH (7.37), and negative blood ketones (<0.5 mmol/L). Her HbA1c was 17.3% …
Identification of antihistone antibodies in subsets of juvenile chronic arthritis.
Authors: M Ostensen, K Fredriksen, E Kass, O P Rekvig
Journal: Annals of the Rheumatic Diseases (1989)

Antihistone antibodies (AHAs) as measured by an enzyme linked immunosorbent assay (ELISA) were detected in the sera of 58 (48%) of 121 unselected patients with juvenile chronic arthritis (JCA). AHAs were found in 28 (93%) of 30 patients with JCA with uveitis but in only 30 (33%) of 91 patients with JCA without uveitis. AHA positivity was unrelated to the type of joint involvement, disease activity, and drug regimen. When the AHA positive group was divided into 28 patients with JCA with uveitis and 30 patients with JCA without uveitis a distinct response pattern of AHA was detected in each group. Anti-H3 dominated in the JCA/uveitis group, whereas a more heterogeneous AHA pattern was shown in the group without uveitis. The results indicate that subtyping for AHA reactivity may define patients who are highly susceptible for the development of anterior uveitis.
Interleukin-10 in Inflammatory Bowel Disease
Authors: Brian Kelsall
Journal: New England Journal of Medicine (2009)

In this issue of the Journal, Glocker et al.1 provide the first substantial support for a functional role for the immunosuppressive cytokine interleukin-10 in the pathogenesis of inflammatory bowel disease in humans. By performing genetic-linkage and candidate-gene analysis of two unrelated consanguineous families with children who have a severe, progressive, poorly treatable form of Crohn's disease that occurs in the first year of life, the investigators identified homozygous, recessive loss-of-function mutations in the interleukin-10 receptor genes, IL10RA and IL10RB, which most likely contributed to the patients' disease. A third distinct mutation in IL10RA was found in an unrelated patient. Finally, . . .
Prospective Randomized Evaluation of Emergency Extracorporeal Shock Wave Lithotripsy (ESWL) on the Short-Time Outcome of Symptomatic Ureteral Stones
Authors: Bertrand Tombal, Hadi Mawlawi, Axel Feyaerts, Francois X. Wese, Reinier Opsomer, Paul J. Van Cangh
Journal: European Urology (2005)
Indian research doesn't reflect country's needs
Authors: G. Mudur
Journal: BMJ (1997)

Most medical research in India is unrelated to the country's major health problems, says a new report which has sparked off a debate on the priorities and relevance of biomedical research.

The report, based on an analysis of research publications from India indexed in the Medline database, says that achievements in research have “little influence” on healthcare delivery. Medical research seems to be concentrated in the fields of tertiary health care and new biology, says the study published in Current Science , a journal of the Indian Academy …
Dislocation and Component Separation of the Bateman Hip Endoprosthesis
Authors: Proctor R. Anderson
Journal: JAMA (1978)

THE BATEMAN hip prosthesis has been used at Northwestern University Medical Center since its introduction three years ago. As indicated by Bateman, the primary indications for this prosthesis are fractures of the femoral head and neck, nonunion of the femoral neck, selected instances of avascular necrosis of the femoral head, and revision of conventional femoral-head prostheses. This prosthesis can also be employed electively in certain cases of posttraumatic arthritis and osteoarthritis and rheumatoid arthritis that preponderantly involve the femoral head.<sup>1</sup> This bipolar-type prosthesis has certain advantages over the Austin-Moore-type prosthesis and the Charnley- or Mueller-type total hip prosthesis. Motion within the double-head assembly of the Bateman permits less motion in the acetabulum, thus providing better acetabular wear and less chance of dislocation.<sup>1</sup> Unusual postoperative complications of the Bateman prosthesis were found in two patients. Both patients required reoperation, thus subjecting them to the further risks of infection and
Effects of Exenatide (Exendin-4) on Glycemic Control and Weight Over 30 Weeks in Metformin-Treated Patients With Type 2 Diabetes
Authors: Ralph A. DeFronzo, Robert E. Ratner, Jenny Han, Dennis D. Kim, Mark S. Fineman, Alain D. Baron
Journal: Diabetes Care (2005)

This study evaluates the ability of the incretin mimetic exenatide (exendin-4) to improve glycemic control in patients with type 2 diabetes failing to achieve glycemic control with maximally effective metformin doses.A triple-blind, placebo-controlled, 30-week study at 82 U.S. sites was performed with 336 randomized patients. In all, 272 patients completed the study. The intent-to-treat population baseline was 53 +/- 10 years with BMI of 34.2 +/- 5.9 kg/m(2) and HbA(1c) of 8.2 +/- 1.1%. After 4 weeks of placebo, subjects self-administered 5 microg exenatide or placebo subcutaneously twice daily for 4 weeks followed by 5 or 10 microg exenatide, or placebo subcutaneously twice daily for 26 weeks. All subjects continued metformin therapy.At week 30, HbA(1c) changes from baseline +/- SE for each group were -0.78 +/- 0.10% (10 microg), -0.40 +/- 0.11% (5 microg), and +0.08 +/- 0.10% (placebo; intent to treat; adjusted P < 0.002). Of evaluable subjects, 46% (10 microg), 32% (5 microg), and 13% (placebo) achieved HbA(1c) < or =7% (P < 0.01 vs. placebo). Exenatide-treated subjects displayed progressive dose-dependent weight loss (-2.8 +/- 0.5 kg [10 microg], -1.6 +/- 0.4 kg [5 microg]; P < 0.001 vs. placebo). The most frequent adverse events were gastrointestinal in nature and generally mild to moderate. Incidence of mild to moderate hypoglycemia was low and similar across treatment arms, with no severe hypoglycemia.Exenatide was generally well tolerated and reduced HbA(1c) with no weight gain and no increased incidence of hypoglycemia in patients with type 2 diabetes failing to achieve glycemic control with metformin.