On the Origin of Amyloid
Authors: JOSEPH GAFNI
Journal: Annals of Internal Medicine (1966)

Case Studies1 November 1966On the Origin of AmyloidStudy of an Amyloid Tumor in Multiple MyelomaJOSEPH GAFNI, M.D., HANS-JOACHIM MERKER, M.D., SHLOMO SHIBOLET, M.D., EZRA SOHAR, M.D., HARRY HELLER, M.D.JOSEPH GAFNI, M.D.Search for more papers by this author, HANS-JOACHIM MERKER, M.D.Search for more papers by this author, SHLOMO SHIBOLET, M.D.Search for more papers by this author, EZRA SOHAR, M.D.Search for more papers by this author, HARRY HELLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-5-1031 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlmost since the discovery of amyloid there has been much speculation as to the mode and site of its formation. Its common association with protracted inflammatory diseases and multiple myeloma implicated the production, presumably by plasma cells, of a soluble abnormal protein that was carried by the circulation to the site of its precipitation by immune mechanisms in the connective tissue ground substance (1-4). The finding of plasma cell infiltrates in meticulously re-examined cases of "primary" amyloidosis added weight to this theory (5, 6). In recent years, however, the local deposition of such a distantly produced precursor has been denied...References1. JUERGENS R: Eine neue Reaktion auf Amyloidkoerper. Arch. Path. Anat. 65: 189, 1875. CrossrefGoogle Scholar2. APITZ K: Die Paraproteinosen (ueber die Stoerung des Eiweisstoffwechsels beim Plasmacytom). Arch. Path. Anat. 306: 1631, 1940. Google Scholar3. VASQUEZDIXON JJFJ: Immunohistochemical analysis of amyloid by the fluorescence technique. J. Exp. Med. 104: 727, 1956. CrossrefMedlineGoogle Scholar4. 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BARTH, M.D., GEORGE G. GLENNER, M.D., THOMAS A. WALDMANN, M.D., ROBERT F. ZELIS, M.D.Primary amyloidosis with “monoclonal” immunoglobulin A proteinemiaDys- und Paraproteinämien bei AmyloidbefallAmyloidosis and the gutAmyloidosen bei chronisch-rheumatischen ErkrankungenColloid Milium: A Histochemical Study*Familial Mediterranean feverElectron-microscope observations on peri-reticulin and peri-collagen amyloidosis in rectal biopsiesElectron Microscope Observations of the Fine Structure of Microsporum Gypseum**From the Department of Zoology, Louisiana State University, Baton Rouge, Louisiana. 1 November 1966Volume 65, Issue 5Page: 1031-1044KeywordsAmyloidosisConnective tissue diseasesElectron microscopyHospital medicineImmunoprecipitationMultiple myelomaPlasma cellsPlasma proteinsResearch grantsSurgeons Issue Published: 1 November 1966 PDF downloadLoading ...