tbuckley/cabot-search huggingface dataset:
Herpes simplex virus infection masquerading as condyloma acuminata in a patient with HIV disease
Authors: P. TONG, D.F. MUTASIM
Journal: British Journal of Dermatology (1996)

Summary Verrucosa lesions in patients with human immunodeficiency virus (HIV) disease may be caused by viruses till her than the human papilloma virus. We describe a 32-year-old HIV-positive black man who presented with a verrucosa lesion of the interlineal cleft that clinically resembled condyloma acuminata or verrucosa carcinoma. Histopathological examination revealed the changes f herpes virus infection, and culture of the tissue confirmed the presence of herpes simplex virus. Human papillomavirus was not detected by in situ hybridization or the polymerase chain reaction. Significant regression of the lesion was seen after 6 weeks of treatment with oral acyclovir.
An economic assessment model for in-center, conventional home, and more frequent home hemodialysis
Authors: Paul Komenda, Meghan B. Gavaghan, Susan S. Garfield, Amy W. Poret, Manish M. Sood
Journal: Kidney International (2011)

More intensive and/or frequent hemodialysis may provide clinical benefits to patients with end-stage renal disease; however, these dialysis treatments are more convenient to the patients if provided in their homes. Here we created a standardized model, based on a systematic review of available costing literature, to determine the economic viability of providing hemodialysis in the home that arrays costs and common approaches for assessing direct medical and nonmedical costs. Our model was based on data from Australia, Canada, and the United Kingdom. The first year start-up costs for all hemodialysis modalities were higher than in subsequent years with modeled costs for conventional home hemodialysis lower than in-center hemodialysis in subsequent years. Modeled costs for frequent home hemodialysis was higher than both in-center and conventional home hemodialysis in the United Kingdom, but lower than in-center hemodialysis and higher than conventional home hemodialysis in Australia and Canada in subsequent years. The higher costs of frequent compared to conventional home hemodialysis were because of higher consumable usage due to dialysis frequency. Thus, our findings reinforce the conclusions of previous studies showing that home-based conventional and more frequent hemodialysis may provide clinical benefit at reasonable costs.
DOUBLE INFECTIONS OF SINGLE CELLS WITH ECHO 7 AND COXSACKIE A9 VIRUSES
Authors: Heihachi Itoh, Joseph L. Melnick
Journal: The Journal of Experimental Medicine (1959)

Virus particles derived from single cells infected with two enteroviruses have been studied. Evidence was obtained to indicate that phenotypic, but not genotypic, mixing occurs between Coxsackie A9 (CAP) and ECHO 7 (E7) viruses. Monkey kidney cultures in monolayer were doubly infected with high multiplicities of CA9 and E7 viruses. During the latent period, the infected cells were suspended, diluted, and distributed under oil into droplets each containing a single cell, as checked by microscopic observation. The virus particles released by individual cells into the microdrop were characterized in differential plaque neutralization tests. Fifteen per cent of the microdrops contained doubly neutralizable particles, 53 per cent yielded either CA9 or E7 particles, and 34 yielded particles of an intermediate character (deficits between 37 and 75 per cent). On passage, the doubly neutralizable particles yielded progeny of both parental types. All passage strains behaved like the corresponding parent strain as regards pathogenicity for newborn mice, which is to say that this property was limited to virus particles with CA9 antigenicity. Coxsackie A9 has a more rapid growth cycle than ECHO 7 in rhesus monkey kidney cell cultures, and a slower one in patas cultures. In rhesus, when E7 virus was added first, CA9 could be added up to 2 hours later, and still a significant number of cells yielded either CA9 or doubly neutralizable virus. The converse was observed in patas cells.
Alleviation of Myocardial Ischemia After Kawasaki Disease by Heparin and Exercise Therapy
Authors: Shigeru Tateno, Masaru Terai, Koichiro Niwa, Toshiaki Jibiki, Hiromichi Hamada, Kumi Yasukawa, Takafumi Honda, Shinji Oana, Yoichi Kohno
Journal: Circulation (2001)

Background —Heparin promotes angiogenesis. We evaluated the effects of combined treatment with heparin and exercise on myocardial ischemia in the chronic stage of Kawasaki disease. Methods and Results —This study was conducted in 7 patients (aged 6 to 19 years) who had a totally occluded coronary artery and stress-induced myocardial ischemia in the collateral-dependent areas. Twice-daily exercise using a bicycle ergometer was performed with increments of 0.5 W/kg every 3 minutes up to maximal exertion for 10 days. Heparin, which immediately increased circulating hepatocyte growth factor, was given intravenously 10 minutes before each exercise period. Newly developed myocardial infarction, ventricular tachyarrhythmia, anginal attack, or hemorrhagic complication was not observed in any patient. Dipyridamole-loading single photon emission computed tomography documented improved myocardial perfusion in the collateral-dependent areas and a significant reduction in total defect scores in all patients after the completion of 20 sessions ( P =0.01). In control patients who did not receive the heparin-exercise therapy, however, stress defect scores remained unchanged (n=1) or increased (n=2) during follow-up. Computerized quantitative coronary angiography provided evidence that the heparin-exercise therapy increased the diameter of the occluded artery to which collaterals terminated ( P =0.001) but not that of the reference artery with which collaterals were not connected ( P =0.96). Conclusions —The findings suggest that a series of heparin and exercise treatments over 10 days may have a dramatic effect on the alleviation of myocardial ischemia in collateral-dependent regions. This may be a safe, noninvasive revascularization therapy for patients with coronary artery occlusion in the chronic stage of Kawasaki disease.
Nitrogen Mustard Therapy
Authors: Emil Freireich
Journal: JAMA (1984)

The beginning of the era of cytotoxic chemotherapy was documented in this signal publication. The title is a concise yet accurate description of the contents of the publication. The trivial name assigned to this chemical —<i>nitrogen mustard</i>—persists today, and the association of the chemical with the word<i>therapy</i>was virtually clairvoyant. The authors report a clinical investigation of only 67 patients. Yet they were able to describe the essential activity of this chemical in the effective palliation of a systemic malignant condition that was resistant to all known methods of treatment. <h3>The Selection of Chemicals for Clinical Trials</h3> The authors point out in this article that the initiation of the first clinical test of chemotherapy early in December 1942 was preceded by extensive investigation of the nature of the interaction of the chemical with other biologic tissues in vitro. These studies included preclinical toxicity study in whole animals
Experimental Atheromatosis: Acid Mucopolysaccharide Content of the Aorta
Authors: ALFRED JAY BOLLET, CHUNI WANG, DAVID ADLERSBERG
Journal: Circulation Research (1960)

Histochemical and chemical studies of the acid mucopolysaccharide content of the aorta were made in rabbits fed cholesterol for up to seven months. Colloidal iron staining suggested an increase in acid mucopolysaccharide content of the aortas with mild atheromatous lesions but not when severe lesions were present. Chemical determination, however, revealed no increase in the concentration of acid mucopolysaccharide in early lesions, but did reveal a significant increase in the more severely atheromatous aortas of rabbits fed cholesterol for 6 months or more.
Anti-Sympathetic Ganglia Antibodies and Postural Blood Pressure in IDDM Subjects of Varying Duration and Patients at High Risk of Developing IDDM
Authors: Steven L Rabinowe, Florence M Brown, Michael Watts, Mark M Kadrofske, Aaron I Vinik
Journal: Diabetes Care (1989)

We examined the sera of 94 subjects with insulindependent diabetes mellitus (IDDM) for the presence of complement-fixing sympathetic ganglia (CF-SG) antibodies. In a cross-sectional analysis (duration 0–43 yr), 22% had detectable CF-SG antibodies. Subjects at high risk for IDDM were also studied. Four groups were studied: group 1 (aged 4–64 yr) islet cell antibodypositive (ICA+) prediabetic subjects, 10 of 19 (53%) were CF-SG+ ; group 2 (aged 6–14 yr) ICA− prediabetic subjects (first-degree relatives of IDDM subjects with either transient hyperglycemia, impaired oral glucose tolerance, and/or first-phase insulin release after intravenous glucose tolerance testing), 4 of 9 (44%) were CF-SG+ (2 of the 4 ICA− CF-SG+ subjects have progressed to IDDM); group 3 (aged 1.5-43 yr) ICA+ IDDM subjects (≤1 yr duration) 6 of 10 (60%) were CF-SG+; and group 4 (aged 8–59 yr) ICA IDDM subjects (≤1 yr duration), 2 of 11 (18%) were CF-SG+. All groups had increased CF-SG compared with controls. Postural blood pressure and simultaneous CF-SG antibody measurements were performed in 28 IDDM subjects. The drop in systolic blood pressure was greater in the CF-SG+ subjects (P &amp;lt; .05), and the frequency of CF-SG was greater in the mean to – 2SD group (P &amp;lt; .03) when data were analyzed within mean ± 2SD of the normal blood pressure response.
Treatment of Rheumatoid Arthritis with Dexamethasone
Authors: Abraham Cohen
Journal: JAMA (1960)

Statistics were gathered on 251 cases of rheumatoid arthritis treated for long and short periods with dexamethasone. In a private clinic there were 187 patients from mines and steel mills. In an arthritis clinic of a general hospital, there was a second group of 64 patients, sedentary workers, who were mostly recipients of public assistance. Of interest was the minimum maintenance dose, the untoward reactions, and the effect of dexamethasone on weight. The drug was more effective for the resting patients; it was possible to reduce the maintenance dose much faster and the final level of maintenance dosage was lower. Untoward reactions included depression of pituitaryadrenal axis, osteoporosis, and increase in weight. Except for the osteoporosis seen in a small percentage of cases, there seemed to be little to fear from the prolonged use of steroids.
Doctor and Nurse: Changing Roles and Relations
Authors: Barbara Bates
Journal: New England Journal of Medicine (1970)

Abstract Among many patient needs, the physician concentrates on diagnosis and treatment and must work with others to provide comprehensive care. Although caring, helping, comfort and guidance are fundamental to nursing, forces within medicine, nursing and society tend to constrict the nurse's role to tasks delegated by medicine. An interprofessional relation characterized by medical authoritarianism and nursing's dependence blocks realization of the full potentials of the doctornurse team. Consequently patient care suffers accordingly. New approaches, including the clinical nurse specialist, the expanded role of the nurse and the physician's assistant, show promise of improving care. Each approach has its advantages; all will require reasoned judgment and joint planning.
Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions
Authors: Aśok C. Antony, Ying-Sheng Tang, Rehana A. Khan, Mangatt P. Biju, Xiangli Xiao, Qing-Jun Li, Xin-Lai Sun, Hiremagalur N. Jayaram, Sally P. Stabler
Journal: Journal of Clinical Investigation (2004)

Cellular acquisition of folate is mediated by folate receptors (FRs) in many malignant and normal human cells. Although FRs are upregulated in folate deficiency and downregulated following folate repletion, the mechanistic basis for this relationship is unclear. Previously we demonstrated that interaction of an 18-base cis-element in the 5′-untranslated region of FR mRNA and a cystolic trans-factor (heterogeneous nuclear ribonucleoprotein E1 [hnRNP E1]) is critical for FR synthesis. However, the molecular mechanisms controlling this interaction, especially within the context of FR regulation and folate status, have remained obscure. Human cervical carcinoma cells exhibited progressively increasing upregulation of FRs after shifting of folate-replete cells to low-folate media, without a proportionate rise in FR mRNA or rise in hnRNP E1. Translational FR upregulation was accompanied by a progressive accumulation of the metabolite homocysteine within cultured cells, which stimulated interaction of the FR mRNA cis-element and hnRNP E1 as well as FR biosynthesis in a dose-dependent manner. Abrupt reversal of folate deficiency also led to a rapid parallel reduction in homocysteine and FR biosynthesis to levels observed in folate-replete cells. Collectively, these results suggest that homocysteine is the key modulator of translational upregulation of FRs and establishes the linkage between perturbed folate metabolism and coordinated upregulation of FRs.
Skin substitute may permit more 'natural' burn healing
Authors: Charles Marwick
Journal: JAMA (1983)

Clinical testing of a novel skin substitute to cover burn wounds is about to enter a new phase. The material was developed in a collaborative project between Massachusetts Institute of Technology, Cambridge, and Massachusetts General Hospital (MGH), Boston. Animal studies are now sufficiently advanced to attempt human testing of a new procedure in which the skin substitute is seeded with autologous epidermal cells and applied as soon as possible after the burn occurs instead of after the wound stabilizes, as has been done in the clinical studies up to now. "We think that using the material already armed with epidermal cells in the acute stage of injury is when we ought to be doing this," said John F. Burke, MD, chief of the trauma services at MGH. Burke and his collaborator, Ioannis V. Yannas, PhD, spoke at a conference on burn injury held by the National Institute of General Medical
Ectopic Production of Chorionic Gonadotropin and Its Subunits by Islet-Cell Tumors
Authors: C. Ronald Kahn, Saul W. Rosen, Bruce D. Weintraub, Stefan S. Fajans, Phillip Gorden
Journal: New England Journal of Medicine (1977)

We measured human chorionic gonadotropin (hCG) and its subunits in 76 patients with islet-cell tumors. Seventeen of 27 patients with functioning islet-cell carcinomas had elevated plasma levels of hCG or one of its subunits (hCG-alpha and hCG-beta). Secretion was often discordant; the most frequent finding was an elevated level of hCG-alpha alone. In one patient responding to streptozocin, changes in hCG-alpha correlated with the clinical course. Studies of tumor extracts suggested that the markers observed in the circulation were being produced in the tumor itself. In contrast, none of the 43 patients with benign disease or the six patients with nonfunctioning malignant tumors had elevated levels of hCG, hCG-alpha or hCG-beta. These data show that hCG and its subunits are prevalent and specific markers for islet-cell carcinoma, and suggest that ectopic secretion results from malignant derepression of the genome rather than overproduction by an aberrant "cell rest."
Instant Mobile Communication, Efficiency, and Quality of Life
Authors: Jamie Spiegelman
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rivaroxaban was noninferior to enoxaparin for preventing short-term recurrent VTE and superior to placebo in continued treatment
Authors: James Douketis
Journal: Annals of Internal Medicine (2011)

ACP Journal Club17 May 2011Rivaroxaban was noninferior to enoxaparin for preventing short-term recurrent VTE and superior to placebo in continued treatmentJames Douketis, MDJames Douketis, MDSt. Joseph’s Hospital, Hamilton, Ontario, Canada (J.D.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-10-201105170-02006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationThe EINSTEIN Investigators. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med. 2010;363:2499-510. https://pubmed.ncbi.nlm.nih.gov/21128814Clinical Impact RatingsHematology: References1 Frydman A. Low-molecular-weight heparins: an overview of their pharmacodynamics, pharmacokinetics and metabolism in humans. Haemostasis. 1996;26 Suppl 2:24-38. [PMID: 8707165] Google Scholar2 Eriksson BI, Quinlan DJ, Weitz JI. Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor Xa inhibitors in development. Clin Pharmacokinet. 2009;48:1-22. [PMID: 19071881] Google Scholar3 Kearon C, Kahn SR, Agnelli G, et al. Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest. 2008;133:454S-545S. [PMID: 18574272] Google Scholar4 Lassen MR, Raskob GE, Gallus A, et al. Apixaban or enoxaparin for thromboprophylaxis after knee replacement. N Engl J Med. 2009;361:594-604. [PMID: 19657123] Google Scholar5 Douketis JD. Pharmacologic properties of the new oral anticoagulants: a clinician-oriented review with a focus on perioperative management. Curr Pharm Des. 2010;16:3436-41. [PMID: 20858185] Google Scholar Author, Article, and Disclosure InformationAuthors: James Douketis, MDAffiliations: St. Joseph’s Hospital, Hamilton, Ontario, Canada (J.D.)This article was published at Annals.org on 3 May 2011. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoApixaban reduced VTE and did not increase major bleeding compared with enoxaparin in hip replacement James Douketis Metrics 17 May 2011Volume 154, Issue 10 Page: JC5-6 Keywords Anticoagulants Apixaban Deep vein thrombosis Drugs Hemorrhage Low molecular weight heparin Safety Surgery Venous thromboembolism Vitamin K ePublished: 17 May 2011 Issue Published: 17 May 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The relation between cholesterol absorption and cholesterol synthesis in the baboon
Authors: Jean D. Wilson
Journal: Journal of Clinical Investigation (1972)

To determine the relation between cholesterol absorption, total endogenous cholesterol synthesis, and hepatic cholesterol synthesis in a primate, cholesterol synthesis has been studied in biopsies of liver and ileum from normal baboons fed varying amounts of cholesterol and in biopsies of liver from baboons that had been subjected to ileal diversion. In addition, total cholesterol production rates, cholesterol absorption, and total endogenous cholesterol synthesis have been measured in these animals by a double isotope technique in which the animals were given a single injection of cholesterol-4-(14)C and fed constant amounts of cholesterol-1,2-(3)H for 4 months. From these studies, it has been concluded that on a low cholesterol intake cholesterol synthesis in the liver accounts for about three-fourths of total endogenous cholesterol production. The feeding of cholesterol produces complete inhibition of hepatic synthesis in the normal animal only when absorption approximates the amount synthesized by the liver when no cholesterol is fed, e.g., 400-500 mg/day. Finally, the intestine, which does not possess complete negative feedback control of cholesterol synthesis when cholesterol is fed, may be a significant site of nonhepatic cholesterol synthesis in these animals. In studies of four baboons subjected to ileal diversion, it was concluded that the regulation of cholesterol synthesis is distinctly different when the enterohepatic circulation is interrupted. These animals did not exhibit negative feedback of hepatic cholesterol synthesis when cholesterol was fed, despite the fact that cholesterol absorption approximated that of normal animals fed similar diets. The inference has been drawn that bile acids may be involved directly or indirectly in the regulation of hepatic cholesterol synthesis in this species or that the ileum itself may modulate the hepatic negative feedback.
Physicochemical characteristics of pH-sensitive poly(l-Histidine)-b-poly(ethylene glycol)/poly(l-Lactide)-b-poly(ethylene glycol) mixed micelles
Authors: Haiqing Yin, Eun Seong Lee, Dongin Kim, Kwang Hee Lee, Kyung T. Oh, You Han Bae
Journal: Journal of Controlled Release (2007)
The Challenge of Herbal Therapies for Prostate Cancer
Authors: Rupal S. Bhatt, Glenn J. Bubley
Journal: Clinical Cancer Research (2008)

Abstract The paper by Singh et al. shows that silibinin inhibits prostate cancer growth in the TRAMP mouse model. Among its other properties, silibinin inhibits the progression of prostate cancer by decreasing angiogenesis and tumor invasion. Identification of the biological effects of herbal remedies such as silibinin is critical for their development as anticancer treatments.
Occupational accidents and summer time.
Authors: M. Hillman
Journal: BMJ (1989)

three patients who required vitrectomy in the past 12 months were from this district (which has a population of 400 000).Sufficient treatment is hard to define but includes assessment of location, size, and number of effective burns; the counter on the laser photocoagulator is not a good guide.Never- theless, patients often need more than the 2000 burns that Dr Richardson and his colleagues regard as being indisputably adequate, and even as many as 13000 burns have been necessary and effective on occasion.2Although it is gratifying to have the technology to salvage some vision in patients with late complications of diabetic retinopathy, how much better it would be to prevent these complications in the first place.Screening for sight threatening diabetic retinopathy followed by timely, adequate photo- coagulation is effective in minimising blindness; vitrectomy should become a rare sign of failure of this service.Diabetes is the commonest cause of registrable blindness in people of working age.Provision of screening and photocoagulation services for diabetic retinopathy must merit a high priority in every district.