tbuckley/cabot-search huggingface dataset:
Bone Scan of Recurrent Colon Carcinoma Involving the Sacrum and Urinary Bladder
Authors: CHARLES A. STEWART, MICHAEL E. SIEGEL, WARREN A. NAFIS, LEE A. WOOD
Journal: Clinical Nuclear Medicine (1990)

A bone scan performed for the evaluation of recurrent colon carcinoma demonstrated a well-circumscribed filling defect in the urinary bladder. Because of retained activity in the bladder, 24-hour follow-up and lateral images were needed to demonstrate involvement of the sacrum as well.
RADIATION IN PRIMARY OPERABLE BREAST CANCER
Authors: DOUGLAS QUICK
Journal: JAMA (1933)

Until very recently, general acceptance of irradiation in breast cancer has been limited to postoperative therapy and to the palliative care of inoperable, recurrent and metastatic growths. The only contact with the disease in its more favorable stages has been that following operation. It is even questionable whether this has been as altruistic as might seem on the surface. All too frequently the case is referred, following operation, for postoperative irradiation as a gesture and for diplomatic reasons. Unfortunately, the manner in which the postoperative therapy, at times, is given, may justify to some degree this view on the part of the surgeon. In only a limited way has there been a close cooperation between surgery and radiation therapy in the field of breast cancer. While it represents one of the largest groups of cancer, it has not generally received the cooperative effort between surgery and irradiation that has been
TCT-258 Elaboration of a New Risk Score for Predicting Distal Embolization during Primary Angioplasty in ST-Elevation Myocardial Infarction
Authors: Massimo Napodano, Ahmed Hussien Hussien Al Mamary, Gilberto Dariol, Anna C. Frigo, Giuseppe Tarantini, Paolo Buja, Gianpiero D'Amico, Marco Mojoli, Sabino Iliceto
Journal: Journal of the American College of Cardiology (2013)
Localization of adenosine deaminase and adenosine deaminase complexing protein in rabbit heart. Implications for adenosine metabolism.
Authors: W P Schrader, C A West
Journal: Circulation Research (1990)

The distribution of adenosine deaminase and adenosine deaminase complexing protein in rabbit heart has been compared using immunohistochemical staining procedures. Sections (4-5 microns) of tissue fixed in Clarke's solution or paraformaldehyde and embedded in paraffin were stained by the peroxidase anti-peroxidase method for adenosine deaminase or complexing protein, using affinity purified antibodies. Staining for adenosine deaminase and complexing protein was observed in the central myocardium of all heart chambers. Adenosine deaminase was detected in endothelial cells of blood vessels and adjacent pericytes. The nuclei of arteries stained heavily for adenosine deaminase, whereas those of venules and small veins, although positive, stained much more lightly. The cytoplasm of blood vessel endothelial cells and smooth muscle cells of the tunica media were also weakly positive for adenosine deaminase. Endothelial cells of the endocardium and epicardium did not stain. Randomly distributed mononuclear inflammatory cells and interstitial connective tissue fibroblasts were also negative for adenosine deaminase. These results raise the possibility that endothelial cells containing adenosine deaminase could serve as a metabolic barrier preventing the free exchange of plasma and interstitial adenosine. Positive staining for complexing protein was restricted to blood vessel endothelial cells, especially cytoplasmic processes. Colocalization experiments carried out with biotinylated primary antibodies indicate that some vessels are positive for both adenosine deaminase and complexing protein. This is the first experimental evidence of possible in situ association of adenosine deaminase and complexing protein.
Abstract 1074: Dishevelled 3 (Dvl3) is upregulated and enhances cell migration and invasion in hepatocellular carcinoma
Authors: Yu Man Tsui, Edmund Kwok-Kwan Tung, Carmen Ka-Man Mak, Irene Oi-Lin Ng
Journal: Cancer Research (2011)

Abstract Hepatocellular carcinoma (HCC) is one of the most common fatal malignancies in the world and is particularly prevalent in China and Southeast Asia. Although the risk factors are well known, the molecular mechanisms underlying hepatocarcinogenesis is unclear. Alteration of Wnt signaling pathway is one of the key events in HCC development and so we performed a low-density array (LDA) analysis on 38 pairs of HCC samples and their corresponding non-tumorous livers to examine the expression profiles of different Wnt signaling components. We found that, among the genes studied, Dishevelled 3 (Dvl3) was significantly overexpressed in HCCs as compared with the corresponding non-tumorous liver tissues. In addition, Dvl3 overexpression in HCC was significantly associated with presence of venous invasion (P = .021). The overexpression result was confirmed by expansion of the sample size using quantitative real-time PCR (q-PCR). Next, we investigated the effects of Dvl3 on the migratory and invasive abilities of HCC cells. We established stable shRNA Dvl3-knockdown clones in PLC/PRF/5 HCC cells and found that knockdown of Dvl3 suppressed the migratory and invasive abilities of HCC cells using transwell migration and invasion assays, respectively, suggesting an enhancing role of Dvl3 in HCC cell movement and cell invasion. Although cell proliferation assay in vitro showed no significant difference between the stable Dvl3 knockdown and non-target control PLC/PRF/5 cells, in vivo study in SCID mice showed that the stable Dvl3-knockdown cells resulted in a lower incidence of tumors formed and a smaller tumor size. Furthermore, since Dvl3 is an upstream regulator of the Wnt/β-catenin pathway, using the TOPFOP luciferase reporter assay, we found that transient transfection of Dvl3 in PLC/PRF/5 and BEL-7402 HCC cell lines enhanced the β-catenin-dependent transcriptional activity. In conclusion, upregulation of Dvl3 was frequent in human HCCs. Dvl3 enhanced cell migration and invasion in vitro and tumorigenicity in vivo in SCID mice, and activated canonical β-catenin pathway. It may play an oncogenic role in HCC development. (This study was funded by Hong Kong Research Grants Council CRF grants (RGC CRF HKU1/06C and HKU 7/CRG/09).) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1074. doi:10.1158/1538-7445.AM2011-1074
Heredity and Leg Ulcers
Authors: S. T. Anning
Journal: BMJ (1950)

Accurate knowledge of the aetiology of any disease is necessary for its rational treatment.This applies equally to preventive treatment, and it was with this in mind that the present investigation was carried out to learn more about heredity in relation to gravitational ulcers of the leg.Its place in the aetiology of these ulcers has never been soundly established, though many authors have expressed the opinion that it may be important.Weber, Rast, and Lutterotti (1930) described chronic ulceration of the legs following pneumonia in a man aged 25 with thrombo- angiitis obliterans whose father had suffered from similar ulcers, and Carleton (1948) reported a striking family history in two sisters with leg ulcers.Weber (1948) wrote that there certainly is a constitutional tendency to ulcus cruris in some families.Heredity undoubtedly plays a part in ulceration of the legs associated with purpura haemor- rhagica, sickle-cell anaemia, congenital haemolytic icterus, splenic anaemia, Gaucher's disease, and Cooley's anaemia (Weber and Dorner,
SPONTANEOUS RUPTURE OF ABDOMINAL WOUND
Authors: Max Danzis
Journal: JAMA (1924)

A woman, aged 42, admitted to the Newark Beth Israel Hospital, Sept. 18, 1918, had been operated on in a New York hospital, two or three years before, for some pelvic condition. This operation left her with a large ventral hernia. Since this operation she had been acting in the capacity of a practical nurse. While thus engaged, one day she felt the scar on her abdomen give way. She was brought to a physician's office, where omentum and intestines were found protruding from the abdomen, and she was transferred to the hospital. In attempting to free the adhesions, which were very extensive, from the skin, I noticed a small opening in the bowel. Continued separation resulted in further tears in the intestinal wall. It was noticed at this time that there was a tapeworm protruding from the proximal end of the torn intestine. About 15 feet of the worm
Mortality and Cardiovascular Events in Patients Treated With Homocysteine-Lowering B Vitamins After Coronary Angiography
Authors: Marta Ebbing, Øyvind Bleie, Per Magne Ueland, Jan Erik Nordrehaug, Dennis W. Nilsen, Stein Emil Vollset, Helga Refsum, Eva Kristine Ringdal Pedersen, Ottar Nygård
Journal: JAMA (2008)

<h3>Context</h3>Observational studies have reported associations between circulating total homocysteine concentration and risk of cardiovascular disease. Oral administration of folic acid and vitamin B<sub>12</sub> can lower plasma total homocysteine levels.<h3>Objective</h3>To assess the effect of treatment with folic acid and vitamin B<sub>12</sub> and the effect of treatment with vitamin B<sub>6</sub> as secondary prevention in patients with coronary artery disease or aortic valve stenosis.<h3>Design, Setting, and Participants</h3>Randomized, double-blind controlled trial conducted in the 2 university hospitals in western Norway in 1999-2006. A total of 3096 adult participants undergoing coronary angiography (20.5% female; mean age, 61.7 years) were randomized. At baseline, 59.3% had double- or triple-vessel disease, 83.7% had stable angina pectoris, and 14.9% had acute coronary syndromes.<h3>Interventions</h3>Using a 2 × 2 factorial design, participants were randomly assigned to 1 of 4 groups receiving daily oral treatment with folic acid, 0.8 mg, plus vitamin B<sub>12</sub>, 0.4 mg, plus vitamin B<sub>6</sub>, 40 mg (n = 772); folic acid plus vitamin B<sub>12</sub> (n = 772); vitamin B<sub>6</sub> alone (n = 772); or placebo (n = 780).<h3>Main Outcome Measures</h3>The primary end point was a composite of all-cause death, nonfatal acute myocardial infarction, acute hospitalization for unstable angina pectoris, and nonfatal thromboembolic stroke.<h3>Results</h3>Mean plasma total homocysteine concentration was reduced by 30% after 1 year of treatment in the groups receiving folic acid and vitamin B<sub>12</sub>. The trial was terminated early because of concern among participants due to preliminary results from a contemporaneous Norwegian trial suggesting adverse effects from the intervention. During a median 38 months of follow-up, the primary end point was experienced by a total of 422 participants (13.7%): 219 participants (14.2%) receiving folic acid/vitamin B<sub>12</sub> vs 203 (13.1%) not receiving such treatment (hazard ratio, 1.09; 95% confidence interval, 0.90-1.32; P = .36) and 200 participants (13.0%) receiving vitamin B<sub>6</sub> vs 222 (14.3%) not receiving vitamin B<sub>6</sub> (hazard ratio, 0.90; 95% confidence interval, 0.74-1.09; P = .28).<h3>Conclusions</h3>This trial did not find an effect of treatment with folic acid/vitamin B<sub>12</sub> or vitamin B<sub>6</sub> on total mortality or cardiovascular events. Our findings do not support the use of B vitamins as secondary prevention in patients with coronary artery disease.<h3>Trial Registration</h3>clinicaltrials.gov Identifier: NCT00354081
DISEASES OF THE RETICULOENDOTHELIAL SYSTEM AND HEMATOLOGY PURPURA: A REVIEW OF SELECTED ASPECTS OF THE HEMORRHAGIC DISORDERS
Authors: Mario Stefanini, William Dameshek
Journal: Annual Review of Medicine (1954)

Postpartum depression (PPD) is common, disabling, and treatable. The strongest risk factor is a history of mood or anxiety disorder, especially having active symptoms during pregnancy. As PPD is one of the most common complications of childbirth, it is ...Read More
Finger-Pad Tophi
Authors: K F Chopra, P Schneiderman, M E Grossman
Journal: New England Journal of Medicine (2002)

Hyperuricemia and gout are known to occur in patients receiving diuretic therapy. More recently recognized, however, is the occurrence of tophaceous gout in patients treated with cyclosporine. We report a 57-year-old man with normal renal function who was started on cyclosporine immediately after undergoing bilateral lung transplantation. Six months later, he developed progressive renal insufficiency and hypertension. In the following four months (10 months after starting his immunosuppressant medication), he presented with a symmetrical distribution of tophi on his finger pads. Seven previous cases of finger pad tophi have been reported and are reviewed.
Mechanical unloading reverses transverse tubule remodelling and normalizes local Ca<sup>2+</sup>‐induced Ca<sup>2+</sup>release in a rodent model of heart failure
Authors: Michael Ibrahim, Manoraj Navaratnarajah, Urszula Siedlecka, Christopher Rao, Priyanthi Dias, Alexey V. Moshkov, Julia Gorelik, Magdi H. Yacoub, Cesare M. Terracciano
Journal: European Journal of Heart Failure (2012)

Ca(2+)-induced Ca(2+) release (CICR) is critical for contraction in cardiomyocytes. The transverse (t)-tubule system guarantees the proximity of the triggers for Ca(2+) release [L-type Ca(2+) channel, dihydropyridine receptors (DHPRs)] and the sarcoplasmic reticulum Ca(2+) release channels [ryanodine receptors (RyRs)]. Transverse tubule disruption occurs early in heart failure (HF). Clinical studies of left ventricular assist devices in HF indicate that mechanical unloading induces reverse remodelling. We hypothesize that unloading of failing hearts normalizes t-tubule structure and improves CICR.Heart failure was induced in Lewis rats by left coronary artery ligation for 12 weeks; sham-operated animals were used as controls. Failing hearts were mechanically unloaded for 4 weeks by heterotopic abdominal heart transplantation (HF-UN). HF reduced the t-tubule density measured by di-8-ANEPPS staining in isolated left ventricular myocytes, and this was reversed by unloading. The deterioration in the regularity of the t-tubule system in HF was also reversed in HF-UN. Scanning ion conductance microscopy showed the reappearance of normal surface striations in HF-UN. Electron microscopy revealed recovery of normal t-tubule microarchitecture in HF-UN. L-type Ca(2+) current density, measured using whole-cell patch clamping, was reduced in HF but unaffected by unloading. The variance of the time-to-peak of the Ca(2+) transient, an index of CICR dyssynchrony, was increased in HF and normalized by unloading. The increased Ca(2+) spark frequency observed in HF was reduced in HF-UN. These results could be explained by the recoupling of orphaned RyRs in HF, as indicated by immunofluorescence.Our data show that mechanical unloading of the failing heart reverses the pathological remodelling of the t-tubule system and improves CICR.
Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells
Authors: Noriyuki Fujikado, Shinobu Saijo, Tomo Yonezawa, Kazusuke Shimamori, Akina Ishii, Sho Sugai, Hayato Kotaki, Katsuko Sudo, Masato Nose, Yoichiro Iwakura
Journal: Nature Medicine (2008)
Presidential Politics and the Resurgence of Health Care Reform
Authors: Jonathan Oberlander
Journal: New England Journal of Medicine (2007)

Health care reform is back in vogue as the 2008 election approaches. Jonathan Oberlander writes that the issue is playing out very differently in the parties' presidential primaries. Jonathan Oberlander discusses the health care plans of the presidential candidates and the striking differences between the two parties' approaches to health care reform.
PREFERENTIAL RECOMBINATION OF ANTIBODY CHAINS TO FORM EFFECTIVE BINDING SITES
Authors: O. A. Roholt, G. Radzimski, D. Pressman
Journal: The Journal of Experimental Medicine (1965)

The recovery of hapten-binding activity by a mixture of H and L polypeptide chains of the whole gammaG-immunoglobulin fraction from rabbit anti-p-azobenzenearsonate (Rp) serum is almost as great as that by a mixture of H and L chains from specifically purified Rp antibody. Random combination among the H and L chains from the anti-Rp antibodies and the normal gammaG-immunoglobulin present would result in little recovery of hapten-binding activity. This suggests a preferential recombination of H and L chains from antibody. Mixtures of H or L chains from anti-p-azobenzoate (Xp) antibody and the complementary chains from antibody-depleted gammaG-immunoglobulin show little hapten-binding. When anti-Xp antibody H chains are added to mixtures of one equivalent of anti-Xp L chain and increasing amounts of non-specific L chain, the hapten-binding by the mixtures decreases, but not as much as if the H chains combined with the L chains randomly. Hapten was not present during these recombination procedures. These data indicate that in the cases of anti-Xp and of anti-Rp antibodies, there is a selective combination between those H and L chains which give effective hapten binding regions.
Medial Artery Calcification Predicts Cardiovascular Mortality in Patients With NIDDM
Authors: Leo Niskanen, Onni Siitonen, Matti Suhonen, Matti I Uusitupa
Journal: Diabetes Care (1994)

OBJECTIVE To study the predictive value of medial artery calcification (Mönckeberg's sclerosis) in relation to 10-year cardiovascular mortality in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS We studied the predictive value of thigh medial and intimal artery calcifications to 10-year cardiovascular mortality in a well-characterized group of 133 middle-aged, newly diagnosed patients with NIDDM (70 men and 63 women). RESULTS At baseline, medial artery calcifications were found in 17% of the patients and intimal-type calcifications were found in 23%. During the follow-up, 21% of the diabetic patients died from cardiovascular causes. The age-adjusted odds ratio for cardiovascular mortality was 4.2 (95% confidence intervals: 1.5−11.3) for medial-type and 1.6 (0.6−4.3) for intimal-type calcifications. In multiple logistic regression analysis, including age, sex, systolic blood pressure, low-density- and high-density-lipoprotein cholesterol, very-low-density lipoprotein triglycerides, smoking, body mass index, fasting serum insulin, blood glucose, urinary albumin, and ischemic ECG changes, as well as the intimal artery calcification, the medial artery calcification was the dominant factor predicting cardiovascular mortality. CONCLUSIONS In this study medial artery calcification was a strong independent predictor of cardiovascular mortality in patients with newly diagnosed NIDDM. Whether these subjects had a longer duration of hyperglycemia before the diagnosis than those without medial artery calcifications remains unknown.
Checklists and Guidelines
Authors: Frank Davidoff
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
408 The effects of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) and 1-acyl-2-acetyl-sn-glycero-3-phosphocholine (AAPC) on human basophil mediator release
Authors: M COLOMBO, E HOROWITZ, V PATELLA, A KAGEYSOBOTKA, D MACGLASHANJR, F CHILTON, L LICHTENSTEIN
Journal: Journal of Allergy and Clinical Immunology (1991)
Chromosome Rearrangements and the Evolution of Genome Structuring and Adaptability
Authors: A. Crombach, P. Hogeweg
Journal: Molecular Biology and Evolution (2007)

Eukaryotes appear to evolve by micro and macro rearrangements. This is observed not only for long-term evolutionary adaptation, but also in short-term experimental evolution of yeast, Saccharomyces cerevisiae. Moreover, based on these and other experiments it has been postulated that repeat elements, retroposons for example, mediate such events.
Evolution and transmission of drug-resistant tuberculosis in a Russian population
Authors: Nicola Casali, Vladyslav Nikolayevskyy, Yanina Balabanova, Simon R Harris, Olga Ignatyeva, Irina Kontsevaya, Jukka Corander, Josephine Bryant, Julian Parkhill, Sergey Nejentsev, Rolf D Horstmann, Timothy Brown, Francis Drobniewski
Journal: Nature Genetics (2014)
TCT-90 MitraClip Therapy in Patients at High Surgical Risk: Classification Tree Analysis to Reveal the Interrelation of Baseline Echocardiographic Variables Impacting Acute Procedural Outcome
Authors: Michael Schlüter, Eik Vettorazzi, Volker Rudolph, Edith Lubos, Britta Goldmann, Daniel Lubs, Hendrik Treede, Johannes Schirmer, Lenard Conradi, Hermann Reichenspurner, Stephan Baldus, Stefan Blankenberg
Journal: Journal of the American College of Cardiology (2013)
Extra-articular manifestations of rheumatoid arthritis: risk factors for serious gastrointestinal events.
Authors: A E Voskuyl, M A Van de Laar, H J Moens, J K Van der Korst
Journal: Annals of the Rheumatic Diseases (1993)

Serious upper gastrointestinal events are an important threat to patients with arthritis who are treated with non-steroidal anti-inflammatory drugs (NSAIDs). In this study risk factors for serious upper gastrointestinal events are identified in patients with possible or definite rheumatoid arthritis (RA).A retrospective analysis of factors that might contribute to the risk of serious upper gastrointestinal events was performed in a cohort of 2315 consecutive patients with possible or definite RA. The relative influences of disease severity, drug treatment, particularly with corticosteroids, and history of peptic ulceration were analysed with a conditional logistic regression model for the 106 patients with serious upper gastrointestinal intestinal events and for an equal number of control patients who were matched for age, gender, number of criteria for RA, and disease duration.The incidence rate for serious upper gastrointestinal events was 4.0/1000 patients in each year. The study reconfirmed that age over 60 years, history of peptic ulceration, and use of corticosteroids are risk factors. The presence of extra-articular manifestations of RA was associated with a two to 11-fold increase in the risk for serious upper gastrointestinal events. This risk was independent of the use of corticosteroids.Disease severity, in particular the presence of extra-articular features, may be an important factor in the pathogenesis of upper gastrointestinal ulceration in patients with RA who are treated with NSAIDs.