tbuckley/cabot-search huggingface dataset:
Infection, Absent Tachycardia, Cancer History, and Severe Coma Are Independent Mortality Predictors in Geriatric Patients With Hyperglycemic Crises
Authors: Chien-Cheng Huang, Tsair-Wei Chien, Shih-Bin Su, How-Ran Guo, Wei-Lung Chen, Jiann-Hwa Chen, Su-Hen Chang, Hung-Jung Lin, Yi-Fong Wang
Journal: Diabetes Care (2013)

Hyperglycemic crises present a disease continuum of diabetic emergency. There are three types of hyperglycemic crisis in clinical practice: 1 ) diabetic ketoacidosis (DKA), 2 ) hyperosmolar hyperglycemic state (HHS), and 3 ) mixed DKA/HHS (1,2). The prevalence of diabetes in the elderly is extremely high and growing (3–5). The elderly also have a higher mortality risk for hyperglycemic crises; therefore, it is particularly important to identify patients at risk within the geriatric population because early detection and intervention are beneficial (3–5). We investigated independent mortality predictors in geriatric patients with hyperglycemic crises and combined these predictors to predict the prognosis.

This study was conducted in a university-affiliated medical center. Consecutive elderly (≥65 years) patients who visited our emergency department between January 2004 and December 2010 were prospectively enrolled when they met the criteria of a hyperglycemic crisis (1). One hundred and …
Respiratory Infections in Early Life and the Development of Islet Autoimmunity in Children at Increased Type 1 Diabetes Risk
Authors: Andreas Beyerlein, Fabienne Wehweck, Anette-Gabriele Ziegler, Maren Pflueger
Journal: JAMA Pediatrics (2013)

IMPORTANCEThere is evidence for a role of infections within the pathogenesis of islet autoimmunity and type 1 diabetes mellitus (T1D), but previous studies did not allow assessment of potential critical time windows in this context.OBJECTIVE To examine whether early, short-term, or cumulative exposures to episodes of infection and fever during the first 3 years of life were associated with the initiation of persistent islet autoimmunity in children at increased T1D risk.DESIGN Prospective cohort study with daily infection records and regular assessment of islet autoimmunity.
Hypochondriasis and Somatization-Reply
Authors: Robert Kellner
Journal: JAMA (1988)

ABSTRACT In Reply. —Dr Weintraub raised many issues and I cannot reply adequately to all in a short letter. He criticized the DSM-III classification of somatiform disorders and suggested another. Classification was not the topic of my article and I could not disregard the DSM-III, which is based on the International Classification of Diseases, ninth edition, and is in general use.Dr Weintraub gives his views on the psychopathology of hypochondriasis. These are conventional theories, but there is little research evidence to support them and they probably apply only to a small minority of hypochondriacal patients.Dr Weintraub suggests that neurologists are the most appropriate physicians to investigate patients with somatiform disorder. This certainly applies to patients whose symptoms might be caused by a neurological disease; other specialists are more suitable for patients who have other symptoms and concerns, such as cardiac or abdominal symptoms or pelvic pain.I agree entirely
53. Preliminary Results of a Pilot Phase I Clinical Trial of Adoptive Immunotherapy for B Cell Lymphoma Using CD8+ T Cells Genetically Modified To Express a Chimeric T Cell Receptor Recognizing CD20
Authors: Oliver W. Press, Jinjuan Wang, Catherine G. Lindgren, Eric Y. Chen, Ajay K. Gopal, John M. Pagel, Xiaojun Qian, Stanley R. Riddell, Philip D. Greenberg, Andrew Raubitschek, Michael C. Jensen
Journal: Molecular Therapy (2006)

Follicular Lymphoma (FL) is the second most common type of Non-Hodgkin's Lymphoma (NHL) in the United States, with over 120,000 Americans living with the disease. FL is considered incurable with conventional therapies and innovative new approaches are needed. We have initiated a pilot Phase I clinical trial to test the feasibility, safety, toxicity, and efficacy of treating patients with relapsed indolent B cell lymphomas with autologous CD8+ cytotoxic T lymphocytes (CTL) that have been genetically modified to express a chimeric T cell receptor (cTCR) recognizing the CD20 antigen present on B cell lymphomas. Five patients have been registered to the protocol to date. Peripheral blood mononuclear cells were obtained from patients by apheresis, activated with anti-CD3 monoclonal antibody and interleukin 2 and transfected by electroporation with a plasmid encoding a CD20-specific scFvFc:zeta chimeric immunoreceptor as well as a neomycin-resistance selection gene. Transfectants were selected using G418, and cloned by limiting dilution. CD8+ clones expressing the cTCR and manifesting CD20-specific cytotoxicity were identified by flow cytometry and chromium-51 cytotoxicity assays. Selected clones were expanded and infused into two of the patients at escalating doses (108, 109, and 3.3 × 109 cells/m2) on three occasions over a period of 10 days. Two additional patients are scheduled for T cell infusions in the near future. One patient is now off study because the clones failed to expand sufficiently to numbers required for therapy. No significant toxicities attributable to the T cell infusions were observed. There have been no cellular or humoral immune responses to the genetically modified T cells in the two treated patients. T cells expressing the cTCR were detectable in the peripheral blood of patients by PCR for 14 days after infusions. One patient was maintained in complete remission for over a year after T cell infusions, and a second patient was maintained in a partial remission for four months. Future planned interventions include infusion of polyclonal populations of transfected CD4 helper T cells with cytotoxic CD8 T cells rather than CD8 clones, subcutaneous administration of low dose interleukin 2, and introduction of a modified plasmid containing CD28 and CD137 co-stimulatory domains in addition to the CD3 zeta chain.
The Kras Mutational Spectra of Chemically Induced Lung Tumors in Different Inbred Mice Mimics the Spectra of KRAS Mutations in Adenocarcinomas in Smokers versus Nonsmokers
Authors: Jason M. Fritz, Lori D. Dwyer-Nield, Bridgette M. Russell, Alvin M. Malkinson
Journal: Journal of Thoracic Oncology (2010)
Effect of bismuth subcitrate on amphibian gastroduodenal bicarbonate secretion.
Authors: C J Shorrock, J R Crampton, L C Gibbons, W D Rees
Journal: Gut (1989)

The ulcer healing and cytoprotective properties of colloidal bismuth (De-Nol) are well established although its mode of action is unclear. We have examined the action of bismuth subcitrate, the active ingredient of De-Nol, on gastroduodenal bicarbonate secretion by isolated amphibian mucosa. Addition of bismuth subcitrate (10(-6) to 10(-4) M) to the luminal solution produced a dose dependent increase in bicarbonate secretion from both gastric and duodenal mucosae without a change in transmucosal potential difference. The magnitude of this stimulation was greater for gastric than duodenal mucosae at all dose ranges. A second bismuth salt, bismuth oxynitrate, produced similar increases in bicarbonate secretion from gastric mucosae. Pretreatment of gastric mucosa with the cyclooxygenase inhibitor, indomethacin (10(-5) and 10(-4) M), did not abolish the secretory response to bismuth subcitrate. Similar treatment with the chloride transport inhibitor, 4-acetamido-49-isothiocyanatostilbene-2,29-disulfonic acid (SITS) (10(-3) M) prevented the secretory response to bismuth subcitrate.
Role of intragastric and intraoesophageal alkalinisation in the genesis of complications in Barrett's columnar lined lower oesophagus.
Authors: S E Attwood, C S Ball, A P Barlow, L Jenkinson, T L Norris, A Watson
Journal: Gut (1993)

Patients with Barrett9s columnar lined lower oesophagus have severe acid gastrooesophageal reflux and may develop complications, including ulceration, stricture, and carcinoma. The aim of this study was to establish if a relationship exists between the pH profile in the oesophagus and stomach and the development of complications in patients with Barrett9s columnar lined lower oesophagus. Twenty four hour ambulatory oesophageal pH monitoring was performed in 26 patients with Barrett9s columnar lined lower oesophagus and combined with 24 hour ambulatory gastric pH monitoring in 16. Ten of the 26 with Barrett9s columnar lined lower oesophagus had complications including stricture (eight), deep ulceration (one), and carcinoma (one). Oesophageal acid exposure (% time &lt; pH 4) was similar in patients with or without complications (19.2% v 19.3% p &gt; 0.05). Oesophageal alkaline exposure (% time &gt; pH 7) was greater in patients with complications (24.2% v 8.4% p &gt; 0.05). Of the 16 patients who underwent gastric pH monitoring there was a clear relationship between gastric and oesophageal alkalinisation in 13. These results support the hypothesis that complications in Barrett9s columnar lined lower oesophagus develop in association with increased exposure of the oesophagus to an alkaline environment which appears to be secondary to duodenogastric reflux. The routine use of 24 hour ambulatory gastric pH monitoring in conjunction with oesophageal pH monitoring can help identify those patients at risk.
The X-Ray Crystal Structure of Two Complexes of the Cockroach Allergen Bla g 2 with Fragments of Monoclonal Antibodies Defines Two Non-overlapping Epitopes
Authors: A. Pomés, M. Li, J. Glesner, S. Wünschmann, E.M. King, M.D. Chapman, A. Wlodawer, A. Gustchina
Journal: Journal of Allergy and Clinical Immunology (2009)
Nonspecific provocation of target organs in allergic diseases: EAACI‐GA<sup>2</sup>LEN consensus report
Authors: S. Bonini, G. Rasi, V. Brusasco, K.‐H. Carlsen, E. Crimi, T. Popov, G. Schultze‐Werninghaus, C. Gramiccioni, M. Bonini, D. Passali, C. Bachert, P. B. Van Cauwenberge, M. Bresciani, S. Bonini, M. Calonge, P. G. Montan, M. Serapiao Dos Santos, R. Belfort, A. Lambiase, M. Sacchetti
Journal: Allergy (2007)

It is widely accepted that nonspecific tissue reactivity is a distinct pathophysiological hallmark of allergic diseases, influenced by genetic and environmental factors different from those involved in causing sensitization and allergen response of target organs. This consensus document aims at reviewing procedures currently used for nonspecific provocation of the bronchi, nose and eye and for measuring their responsiveness to nonspecific stimuli.
Surgeon to Soldiers: Diary and Records of the Surgical Consultant, Allied Force Headquarters, World War II
Authors: Lester S. King
Journal: JAMA (1972)

When we try to understand the past, only time can bring perspective. Now, a full generation after World War II, we are beginning to get that perspective. Of particular interest to physicians and historians is the new book by Edward D. Churchill, formerly the chief of surgery at the Massachusetts General Hospital in Boston, who narrates his experiences in the war and the transitions from civil to military medicine. Although the book lacks good organization, it has the ring of sincerity and truth, and casts a vast amount of oblique light on the medical services during the war, especially in the Mediterranean theater. The account relies in part on direct narration, in part on quotations from diaries, letters, and reports. In the course of the story we glimpse some of the problems of administration, army regulations and red tape, hospital organization, public health problems, logistic and supply difficulties, and the
Gelsolin–derived familial amyloidosis caused by asparagine or tyrosine substitution for aspartic acid at residue 187
Authors: Albert de la Chapelle, Ritva Tolvanen, Gudrun Boysen, Jiri Santavy, Liesbeth Bleeker-Wagemakers, C.P.J. Maury, Juha Kere
Journal: Nature Genetics (1992)
Cephalins in the Blood
Authors: Martin M. Nothman
Journal: JAMA (1962)

AS LONG AGO as 1912, Howell suggested that L the active element in tissue extracts favoring coagulation is a phospholipid of the nature of cephalin.  Robinson and Poole in 1956 observed that the addition of rat chylomicra to plasma from which the fat particles and platelets had been removed by high-speed centrifugation greatly enhanced the quantity of thrombin found in a thrombin generation test. Chylomicra contain a substance resembling phosphatidy ethanolamine in its Chromatographie behavior. It is believed that phosphatidyl ethanolamine or serine is probably the phosphatide of the chylomicra which is active in the coagulation tests. O'Brien demonstrated that the cephalins can, to varying extents, imitate the thromboplastic action of platelets. They may be the active principle in platelets responsible for the accelerated clotting of the blood. Axelrod, Beichenthal, and Brodie determined in 3 normal individuals the amount of phosphatidyl ethanolamine and serine in plasma and red blood cells
&lt;emph type="ital"&gt;Thirteen Standing Figures&lt;/emph&gt;
Authors: Thomas B. Cole
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Somatic Complaints Associated with Depressive Symptoms in HIV-Positive Patients
Authors: Isao Fukunishi, Tomoko Matsumoto, Masayoshi Negishi, Motoko Hayashi, Takashi Hosaka, Hirofumi Moriya
Journal: Psychotherapy and Psychosomatics (1997)

Background: Although several studies have indicated the association of mood states including depression with somatic complaints in HIV patients, there has been no report on Japanese HIV patients. The purpose was to examine the relationship between somatic complaints and mood states in HIV patients without AIDS. Methods: Subjects were 50 HIV patients without AIDS. As controls, we used 47 healthy persons without HIV, matched for age and gender of the subjects. After the Structured Clinical Interview for the DSM-III-R, several inventories including the Profile of Mood States (POMS) were administered. The presence or absence of somatic complaints were examined. Results: No patients fulfilled the criteria for the DSM-III-R Mood Disorders Including Major Depression. However, scores on depression as measured by the POMS were significantly higher for the HIV group than for the healthy group. Although depressive symptoms in the HIV group may not be strong enough to warrant a psychiatric diagnosis of mood disorders, these HIV patients may be prone to a depressive state. The HIV patients indicated somatic complaints more frequently. Among these, the presence or absence of five complaints (i.e., abdominal distress, sleep disturbance, smothering sensations, chest pain or discomfort, and numbness or chills) was significantly discriminated based on scores on depression. Discussion: The results suggest that depressive symptoms accompany several somatic complaints in HIV patients without AIDS. Although a longitudinal follow-up study is required, the assessments of somatic symptoms may bring clinical benefits such as earlier diagnosis and/or intervention for a depressive state.
Diagnosis of Acute Bacterial Prostatitis by Ga-67 Scintigraphy and SPECT-CT
Authors: Sunil K. Bajaj, John P. Seitz, Feng Qing
Journal: Clinical Nuclear Medicine (2008)

Gallium-67 (Ga-67) is effective in imaging neoplasms and infection; however, its potential role in diagnosis of acute prostatitis is not well reported. We report a 66-year-old male patient who presented with back pain, fever, chills, and elevated white blood count. Plain x-ray of the lumbosacral spine showed degenerative changes in the L4 to L5 intervertebral disc space. The patient subsequently underwent Ga-67 scintigraphy and SPECT-CT for evaluation of diskitis, which showed diffuse intense uptake of Ga-67 within the prostate, suggesting acute prostatitis. There was complete resolution of symptoms after a course of antibiotics.
Harmonisation of specialist training in Europe: is it a mirage?
Authors: S. Brearley
Journal: BMJ (1995)

For the past 18 years there has been a proliferation of European committees, boards, associations, colleges, and working groups set up to promote the harmonisation of specialist training in Europe. It has been taken as read that this objective is desirable. The fact that these bodies have achieved remarkably little is telling, and it is time to question their activity. There are good practical reasons behind the evolution of Europe's disparate training schemes, and the arguments for retaining diversity rather than continuing to strive for homogeneity are persuasive.
Scottish government unveils plan to better integrate health and social care
Authors: B. Christie
Journal: BMJ (2011)

Doctors in Scotland are to be given a greater role in developing services for elderly people under plans to improve the integration of adult health and social care services.

Legislation is to be introduced to create more effective health and social care organisations to replace community health partnerships, which have been criticised for failing to improve the care of elderly people.

The new health and social care partnerships will be expected to deliver on a set of national outcomes, including reducing numbers of emergency admissions to hospital and delayed discharges. Budgets will be integrated across the NHS and local government services. Resources are also to be transferred from …
Comment: The Penultimate in Cancer Diagnosis—Enzymology
Authors: Philip Rubin
Journal: JAMA (1969)

Although morphologic identification of cancer on histologic microsections is considered essential to diagnosis of malignancy, the biochemical examination of body fluids and tissues has supplemented and extended pathologic information. In fact, the borderline areas of hyperplasia and true neoplasia may be defined in this manner. As Utz and Farrow concluded, prognostication will probably increase in accuracy not by refinement of morphologic criteria, but by research in enzymology and histochemistry. If their specifity increases, such procedures may ultimately supplant the need for tissue diagnosis and may guide response to treatment. Interest in body-fluid enzymes in malignant neoplasia has resulted in recent studies in acid phosphatase, alkaline phosphatase, aminopeptidase, LDH, glutathione reductase, ribonuclease, amylase, ulodase, phosphoglucomatase, and phosphohexose isomerase.<sup>69</sup>This is not an exhaustive list, but it reflects current pursuits in cancer enzymology. The basic concepts elaborated by Greenstein<sup>69</sup>are that each tissue has its own enzyme profile as an
Differential Diagnosis of Angina Pectoris
Authors: JOSEPH E.F. RISEMAN
Journal: Circulation (1956)

The diagnosis and differential diagnosis of angina pectoris depend on obtaining an adequate history. Problems in diagnosis arise because of confusion of terminology, language difficulties, symptoms resembling noncardiac disease or vice versa, and the coexistence of angina pectoris with disease of other organs. Problems in differential diagnosis arise because symptoms resembling angina may result from disease or abnormal function of the brain, skeletal system, gastrointestinal system, or structures in the bony thorax or within the thoracic cage. The most difficult problems in differential diagnosis arise from psychoneurosis and gallbladder disease. Careful history taking will resolve the problem in most instances, prolonged observation will settle the question in others. To date, no objective tests have been adequate to determine whether or not the patient is subject to attacks of pain due to the physiologic effects of coronary artery pathology or dysfunction.
Actual causes of death in the United States
Authors: T. J. Tyson
Journal: JAMA (1994)

To the Editor.  —The recent article by Drs McGinnis and Foege 1 identifies and quantifies major nongenetic factors that contribute to death in the United States. They found that 50% of all deaths in 1990 were attributable to tobacco, diet and activity patterns, alcohol, microbial agents, toxic agents, firearms, sexual behavior, motor vehicles, and illicit drug use. McGinnis and Foege then note the significance of these findings for health policy priorities. We wholeheartedly applaud their effort and wish to propose and encourage the development of an etiologically based classification of diseases as a supplement to our current melange known as the International Classification of Diseases. We have been involved in similar research aimed at estimating the contribution of social and behavioral factors to mortality and believe there is great benefit to a cause of death classification system that reflects true etiology.  At present, we classify disease using a potpourri of discordant
Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor
Authors: Nikhil S. Joshi, Weiguo Cui, Anmol Chandele, Heung Kyu Lee, David R. Urso, James Hagman, Laurent Gapin, Susan M. Kaech
Journal: Immunity (2007)
Computed tomography coronary imaging as a gatekeeper for invasive coronary angiography in patients with newly diagnosed heart failure of unknown aetiology
Authors: Gert‐Jan R. ten Kate, Kadir Caliskan, Admir Dedic, W. Bob Meijboom, Lisan A. Neefjes, Olivier C. Manintveld, Boudewijn J. Krenning, Mohammed Ouhlous, Koen Nieman, Gabriel P. Krestin, Pim J. de Feyter
Journal: European Journal of Heart Failure (2013)
CD8α+ Dendritic Cells Are an Obligate Cellular Entry Point for Productive Infection by Listeria monocytogenes
Authors: Brian T. Edelson, Tara R. Bradstreet, Kai Hildner, Javier A. Carrero, Katherine E. Frederick, Wumesh KC, Roger Belizaire, Taiki Aoshi, Robert D. Schreiber, Mark J. Miller, Theresa L. Murphy, Emil R. Unanue, Kenneth M. Murphy
Journal: Immunity (2011)