tbuckley/cabot-search huggingface dataset:
Social Services and Community Health
Authors: W. H. Parry
Journal: BMJ (1971)

dialysate,l is recommended routinely for all chronically dialysed patients.It is suggested that the patient under this treatment can not only substitute iron, folate, and amino-acid losses from the remaining blood into the dialyser, blood sampling for analysis, and to the dialysate, but also effectively utilize these elements incorporated in the diet, according to his real needs.-Weare, etc.,
HEADACHE AND PAIN IN INFLAMMATION OF NASAL SINUSES
Authors: W. Harris
Journal: BMJ (1933)

Sphenoidal SinusPerhaps the most frequent situation of pain is over the occiput, and next in order the vertex and, occasionally, the region supplied by the supraorbital nerve.If 'the Vidian nerve becomes involved by hyperplastic inflamma- tion of the outer wall of the sinus and neuritic changes reach Meckel's ganglion, the spheno-palatine ganglion syndrome may result-that is, neuralgic pains in the supraorbital, ocular, superior maxillary, mastoid, and occipital regions.In some cases they may extend to the shoulder-blade, the arm, and even to the finger-tips.Such symptoms may be accompanied by lachrymation and sneezing attacks.My own experience
New Information for Authors and Readers
Authors: Richard M. Glass
Journal: JAMA (1992)

In 1989,THE JOURNALinstituted new requirements that all authors sign statements of authorship responsibility and financial disclosure, 1 in addition to transfer of copyright. We are now receiving an increasing number of manuscripts with authorship attributed to a group. These include multicenter clinical trials, institutional reports, and statements from various councils and collaborative groups.  Group Authorship   JAMA has permitted authorship to be attributed to a group, as long as all members of that group meet full criteria for authorship 1,2 and sign a statement that each has participated sufficiently in the conception and design of this work and the analysis of the data [when applicable], as well as the writing of the manuscript, to take public responsibility for it. 3 The members of such groups have usually been listed in a box on the first or last page of the article or in the acknowledgment at the end of
Corticosteroids and Pregnancy
Authors: George X. Trimble
Journal: JAMA (1961)

<h3>To the Editor:—</h3> Concerning the question inThe Journal, Jan. 7, p.71, on the possibility of harm to the fetus of the pregnant mother who was given corticosteroids, there is a diversity of opinion. On several occasions, inquiry has been made ofThe Journalconcerning this subject. In the Aug. 7, 1954, issue, p. 1378, the consultant stated that corticosteroids in the latter stage of pregnancy did not affect the course of the pregnancy. However, the infant might "exhibit withdrawal symptoms suggestive of hypoadrenalism immediately after delivery." The investigators cited as responsible for the latter observation (<i>Obstet Gynec</i><b>1</b>:276-281, March, 1953) state that ACTH and cortisone should be avoided during the first trimester. In the Nov. 27, 1954, issue ofThe Journal, p. 1297, the consultant stated there was "no contraindication to the use of moderate amounts of cortisone for 1 or 2 months during the second trimester of
Eliminating Cells Gone Astray
Authors: Michel Sadelain
Journal: New England Journal of Medicine (2011)

The therapeutic use of cells from healthy donors or patients is increasing. Decades ago, transfusion medicine and bone marrow transplantation provided the first successful cell therapeutics and established the foundations for cell delivery. Clinical investigation soon uncovered the double-edged facets of some cell products, which, for example, could correct anemia but also cause alloimmunization or eradicate minimal residual leukemia while inducing potentially lethal graft-versus-host disease (GVHD).1 Cell therapies have acquired a new dimension during the past 15 years with the emergence of engineered cells that are directed to differentiate toward a particular function, are genetically modified, or are reprogrammed before . . .
Impact of climatic change on the northern latitude limit and population density of the disease-transmitting European tick Ixodes ricinus.
Authors: E Lindgren, L Tälleklint, T Polfeldt
Journal: Environmental Health Perspectives (2000)

We examined whether a reported northward expansion of the geographic distribution limit of the disease-transmitting tick Ixodes ricinus and an increased tick density between the early 1980s and mid-1990s in Sweden was related to climatic changes. The annual number of days with minimum temperatures above vital bioclimatic thresholds for the tick's life-cycle dynamics were related to tick density in both the early 1980s and the mid-1990s in 20 districts in central and northern Sweden. The winters were markedly milder in all of the study areas in the 1990s as compared to the 1980s. Our results indicate that the reported northern shift in the distribution limit of ticks is related to fewer days during the winter seasons with low minimum temperatures, i.e., below -12 degrees C. At high latitudes, low winter temperatures had the clearest impact on tick distribution. Further south, a combination of mild winters (fewer days with minimum temperatures below -7 degrees C) and extended spring and autumn seasons (more days with minimum temperatures from 5 to 8 degrees C) was related to increases in tick density. We conclude that the relatively mild climate of the 1990s in Sweden is probably one of the primary reasons for the observed increase of density and geographic range of I. ricinus ticks.
Psychotherapy for Depression
Authors: Judith S. Yongue
Journal: JAMA (1992)

T. Byram Karasu, professor of psychiatry at Albert Einstein College of Medicine, is the chairman of the American Psychiatric Association's Commission on Psychiatric Therapies and the APA Task Force on the Treatment of Psychiatric Disorders. In this book he presents the three predominant psychotherapeutic approaches to depression: psychodynamic, cognitive-behavioral, and interpersonal. Karasu views depression as a spectrum of disorders requiring a flexible model of treatment. There is a shared element to all therapies, ie, the benign human relationship, which includes empathy and a positive regard. The goal of therapy is to establish an alliance whereby affective, cognitive, and/or behavioral change may be produced. Selective system variables may be addressed differently by each mode of therapy. These psychotherapeutic approaches also interact with pharmacological treatment. Each conceptual approach to depression is addressed in its theoretical and technical dimensions. In psychodynamic psychotherapy the core conceptualization of the ideology and pathogenesis of depression is
Disposable Membrane Insert for the Kiil Dialyser
Authors: B. von Hartitzsch, N. A. Hoenich, D. Jolly, T. H. Frost, D. N. S. Kerr
Journal: BMJ (1972)

The use of a presterilized, disposable, mesh-supported membrane envelope in the Watson Marlow Kiil dialyser results in a 12% improvement in urea and creatinine clearance. Priming volume, uptake volume, and ultrafiltration rate are unchanged. Residual blood volume remains small. Blood flow resistance is increased. The envelope therefore offers considerable advantages over conventional assembly for dialysis with a blood pump.
Correction: A unique ectonucleotide pyrophosphohydrolase associated with porcine chondrocyte-derived vesicles.
Authors: I Masuda, J Hamada, A L Haas, L M Ryan, D J McCarthy
Journal: Journal of Clinical Investigation (1995)

The partial amino acid sequence shown in Table II should read as follows:NH2-Glu-Asp-Arg-Thr-Phe-Leu-Val-Gly-Asn
Children's Self-Reports of Psychologic Adjustment and Coping Strategies During First Year of Insulin-Dependent Diabetes Mellitus
Authors: M Kovacs, D Brent, T F Steinberg, S Paulauskas, J Reid
Journal: Diabetes Care (1986)

Psychologic adjustment, assessed by self-ratings of anxiety, self-esteem, and depression, and cognitive as well as behavioral coping strategies, elicited by interview, were monitored longitudinally among school-age children with recent-onset insulin-dependent diabetes mellitus (IDDM). Our article documents the findings over the 1st yr of the illness. From the start, the children viewed themselves as self-confident and emotionally comfortable. The diagnosis of IDDM created minimal emotional upheaval (which faded within 6 mo), despite this cohort's consistent report that the diet, insulin injections, and urine tests were difficult. The most prevalent cognitive strategies for coping with IDDM included wishful thinking, thoughts of forbidden foods, and resentful thoughts. Behavioral coping strategies, including information seeking, were evident from the beginning. The frequency of socially oriented coping behaviors (e.g., showing IDDM management to peers) indicated that the young patients actively tried to adapt to the illness and were more comfortable with aspects of home care than previously thought. Selfrated psychologic adjustment, psychiatric diagnosis, and illness-related coping behaviors were unrelated to one another; psychologic variables were similarly unrelated to the use of socially oriented coping strategies. Therefore, in juvenile cohorts, the presumed association between psychologic status and coping behaviors requires further examination.
Automatic External Defibrillators for Public Access Defibrillation: Recommendations for Specifying and Reporting Arrhythmia Analysis Algorithm Performance, Incorporating New Waveforms, and Enhancing Safety
Authors: Richard E. Kerber, Lance B. Becker, Joseph D. Bourland, Richard O. Cummins, Alfred P. Hallstrom, Mary B. Michos, Graham Nichol, Joseph P. Ornato, William H. Thies, Roger D. White, Bram D. Zuckerman
Journal: Circulation (1997)

HomeCirculationVol. 95, No. 6Automatic External Defibrillators for Public Access Defibrillation: Recommendations for Specifying and Reporting Arrhythmia Analysis Algorithm Performance, Incorporating New Waveforms, and Enhancing Safety
Prostatitis and Ankylosing Spondylitis
Authors: R. M. Mason, R. S. Murray, J. K. Oates, A. C. Young
Journal: BMJ (1958)

BRMSH AlE-D.CAL JOURNA.L carcinoma in the gastric stump-the occurrence of such cases 31, 7, and 17 years after a partial gastrectomy for cancer suggests a new malignancy.In addition there were cases with a double pathology such as gastric or duodenal ulcer with carcinoma; chronic gastritis, simple polyp and cancer; simple and malignant polyp; and malignant polyp and infiltrating carcinoma.These lend force to the dictum of Hurst that gastric carcinoma never develops on a normal mucosa. ConclusionThe emphasis in an earlier clinical diagnosis is upon symptoms, and the taking of a careful clinical history is the first step.Once the suspicion of malignancy is aroused in the mind of the surgeon and investigations are begun, he must be wary of the negative report, for this in the past has led to disaster.Fortunately he can now rely upon three lines of scientific investigation-namely, radiology, gastroscopy, and cytology-and by sifting the evidence they provide he may reasonably hope to advance the detection of this disease and thereby to improve the prospect of cure which only surgery can offer.
Prime suspect: the TCF7L2 gene and type 2 diabetes risk
Authors: Andrew T. Hattersley
Journal: Journal of Clinical Investigation (2007)

Transcription factor-7–like 2 (TCF7L2) is the most important type 2 diabetes susceptibility gene identified to date, with common intronic variants strongly associated with diabetes in all major racial groups. This ubiquitous transcription factor in the Wnt signaling pathway was not previously known to be involved in glucose homeostasis, so defining the underlying mechanism(s) will provide new insights into diabetes. In this issue of the JCI, Lyssenko and colleagues report on their human and isolated islet studies and suggest that the risk allele increases TCF7L2 expression in the pancreatic β cell, reducing insulin secretion and hence predisposing the individual to diabetes (see the related article beginning on page 2155).
Skill of interpreting imperfect investigations
Authors: S. J. McNulty, P. Williams
Journal: BMJ (2011)

Shuster suggests that clinicians should direct their efforts away from encouraging a deeper understanding of statistics towards searching for better investigations that will give a definitive answer, yes or no.1 To strive for a test that is 100% sensitive and specific, with a 100% positive and negative predictive value, though admirable, is probably futile, so clinicians should be trained to interpret better the …
Dynamic Scintigraphy Suggested Renal Malrotation in a Patient With a Kidney Mass on Ultrasound
Authors: Raf R. Verscuren, Luc Mortelmans
Journal: Clinical Nuclear Medicine (2007)

An 8-year-old boy, diagnosed with a "mass" in his right kidney on ultrasound, was sent to our hospital for further investigation and treatment. He underwent dynamic renography with Tc-99m-L,L-ethylenedicysteine. The known mass was shown to be photopenic in the perfusion phase. During the next 35 minutes, a progressively filling and emptying of the lesion was found. The hypothesis that because of a malrotation of the right kidney, the suspected mass corresponded in fact to the pyelon, was confirmed by MRI.
664 ACUTE B HEPATITIS AFTER TRANSFUSION OF RED BLOOD CELLS FROM A DONOR WITH OCCULT HEPATITIS B VIRUS INFECTION
Authors: M. Spreafico, B. Foglieni, L. Raffaele, I. Guarnori, A. Berzuini, M. Andreoletti, A. Colli, D. Prati
Journal: Journal of Hepatology (2010)
Recurrent ischemia more than 1 year after successful percutaneous transluminal coronary angioplasty. An analysis of the extent and anatomic pattern of coronary disease.
Authors: R K Bottner, C E Green, C J Ewels, E Recientes, G A Patrissi, K M Kent
Journal: Circulation (1989)

Of 1,181 consecutive patients who underwent successful percutaneous transluminal coronary angioplasty (PTCA) as an initial revascularization procedure and who had at least 1 year of asymptomatic follow-up, 66 (6%) underwent repeat angiography because of recurrent symptoms or evidence of exercise-induced ischemia. Patients who had revascularization procedures within 1 year of PTCA were not included in the analysis. Mean time to recurrent ischemia was 30.8 +/- 17.4 months (range 12-89 months). At follow-up, 47 patients had angina, 13 had atypical chest pain, two had acute myocardial infarction, and four had positive exercise tests without symptoms. No patient showed spontaneous regression in the extent of coronary artery disease (CAD). As compared with the extent of CAD immediately after PTCA, the extent of CAD at follow-up did not change in 26 patients (39%); it increased by one vessel in 30 (45%), by two vessels in seven (11%), and by three vessels in three (5%). The pattern of CAD seen at follow-up compared with that seen after PTCA was as follows: 18 patients (27%), no change; seven (11%), restenosis only; 30 (45%), progression of CAD at other sites only; and 11 (17%), a combination of restenosis and progression of CAD at other sites. The time to recurrence of ischemia was significantly different between those with restenosis only versus those with progression only (20.1 +/- 9.2 vs. 38.3 +/- 18.5 months) (p less than 0.009). Progression of CAD was equally distributed between dilated and nondilated vessels; however, when progression occurred in the PTCA vessel, it was significantly more likely to be distal to the PTCA site (p less than 0.008).
Lithium carbonate and breast-feeding.
Authors: P A Sykes, J Quarrie, F W Alexander
Journal: BMJ (1976)

Lithium carbonate and breast-feedingLithium carbonate taken during pregnancy has been associated with neonatal hypotonial and congenital heart disease.2There is little information on lithium concentrations in human breast milk or in the serum of breast-fed infants.We have studied such a case. Case reportA 36-year-old woman, gravida 1, para 0+1, had been taking lithium car- bonate for manic depressive psychosis for seven years when pregnancy was confirmed at eight weeks.The pregnancy was allowed to continue.Initially maintained at 800 mg daily, the dose was reduced twice during pregnancy to maintain therapeutic serum levels (see figure).Her mood was more stable than at any previous time, and she needed no other medication apart from routine haematinics.At 38 weeks she went into spontaneous labour last- ing 12 hours and received protective forceps for suspected prematurity.
Spatial heterogeneity of electrical restitution during regional ischemia in rabbit ventricles: Effects on wavebreaks during ventricular fibrillation
Authors: Yen-Bin Liu, Hui-Nam Pak, Yuji Okyama, Hideki Hayashi, Peng-Sheng Chen, Shien-Fong Lin
Journal: Journal of the American College of Cardiology (2003)
Selective urinary excretion of phosphatidyl ethanolamine in patients with chronic glomerular diseases
Authors: Keiji Mimura, Susumu Yukawa, Takao Maeda, Masahiro Kinoshita, Yoichi Yamada, Yasushi Saika, Toshihiko Miyai, Masayoshi Nagae, Masatoshi Mune, Hiroshi Nomoto
Journal: Metabolism (1984)
Observations on the pathogenesis of chronic airflow obstruction in smokers: implications for the detection of "early" lung disease.
Authors: I A Greaves, H J Colebatch
Journal: Thorax (1986)

Observations on the pathogenesis of chronic airflow obstruction in smokers: implications for the detection of "early" lung disease Cigarette smoking causes various pathological changes in the lungs, some of which may lead to chronic airflow obstruction, which is an important cause of respiratory morbidity and mortality.The changes attributable to smoking include large airway effects (mucous gland enlargement and mucous hypersecretion, smooth muscle hypertrophy, atrophy of bronchial walls); small airway changes (bronchiolar inflammation, fibrosis, ulceration, and tortuousity, with diffuse narrowing of the airways); and pulmonary emphysema."5The relative roles of these patholo- gical features in causing chronic airflow obstruction have been examined and two hypotheses for its pathogenesis in smokers have been proposed.The most common condition associated with chronic airflow obstruction in smokers is emphysema, which is usually of the centrilobular type, although mixtures of centrilobular and panlobular changes are also found.34One current concept of the pathogenesis of emphysema is based on an imbalance between proteases and antiproteases in the lung parenchyma;6-8 a relative excess of proteases, particularly elastases, is thought to occur in the lungs of many smokers, and this may promote the dis- ruption of connective tissue fibres.Because the tissue fibre network is essential for the structural integrity of alveoli, proteolytic activity can lead to disruption of alveolar walls and alveolar enlargement.9-1l Alveo- lar enlargement leads to decreased lung elasticity and decreased elastic support of the airway walls. 12 13The resulting decrease in elastic driving pressure and increased likelihood of expiratory airway collapse is responsible, in turn, for decreased maximum expiratory airflow from the lungs and the character- istic spirometric pattern of chronic airflow obstruc- tion.14 5* This hypothesis for the development of *Airflow obstruction' is defined typically as a decreased FEV, (that is, a value less than 80% of that predicted) in the presence of a proportionately smaller decrease in forced vital capacity.As we shall show below, a decreased FEV1 has poor sensitivity for predicting the presence of emphysema.
Genome-Scale Phylogeny and the Detection of Systematic Biases
Authors: Matthew J. Phillips, Frédéric Delsuc, David Penny
Journal: Molecular Biology and Evolution (2004)

Phylogenetic inference from sequences can be misled by both sampling (stochastic) error and systematic error (nonhistorical signals where reality differs from our simplified models). A recent study of eight yeast species using 106 concatenated genes from complete genomes showed that even small internal edges of a tree received 100% bootstrap support. This effective negation of stochastic error from large data sets is important, but longer sequences exacerbate the potential for biases (systematic error) to be positively misleading. Indeed, when we analyzed the same data set using minimum evolution optimality criteria, an alternative tree received 100% bootstrap support. We identified a compositional bias as responsible for this inconsistency and showed that it is reduced effectively by coding the nucleotides as purines and pyrimidines (RY-coding), reinforcing the original tree. Thus, a comprehensive exploration of potential systematic biases is still required, even though genome-scale data sets greatly reduce sampling error.
RENAL FUNCTION AFTER EST
Authors: MELVIN L. SELZER, LAWRENCE B. INDERBITZIN
Journal: American Journal of Psychiatry (1964)

Renal function tests were done on 38 patients receiving EST. The tests were done one day prior to the first EST and on the day following the third EST. A serum creatinine and routine urinalysis were used for the first 26 patients; a 15-minute PSP test on the last 12 patients. The negative test results indicated the 38 patients suffered no renal damage from EST or that the tests employed were not sensitive enough to detect alterations in renal function or renal blood flow(8).
Hydrallazine predisposes to acute cutaneous vasculitis following urography with iopamidol
Authors: N.J. REYNOLDS, T.B. WALLINGTON, J.L. BURTON
Journal: British Journal of Dermatology (1993)

Journal Article Hydrallazine predisposes to acute cutaneous vasculitis following urography with iopamidol Get access N.J. REYNOLDS, N.J. REYNOLDS Department of Dermatology, Bristol Royal Infirmary, Bristol BS2 8HW, U.K. Search for other works by this author on: Oxford Academic Google Scholar T.B. WALLINGTON, T.B. WALLINGTON Department of Immunology. South Western Regional Transfusion Centre, Bristol BS10 5ND, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.L. BURTON J.L. BURTON Department of Dermatology, Bristol Royal Infirmary, Bristol BS2 8HW, U.K. Dr J.L. Burton. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 129, Issue 1, 1 July 1993, Pages 82–85, https://doi.org/10.1111/j.1365-2133.1993.tb03317.x Published: 01 July 1993 Article history Accepted: 28 January 1993 Published: 01 July 1993
Frontline low-dose alemtuzumab with fludarabine and cyclophosphamide prolongs progression-free survival in high-risk CLL
Authors: Christian H. Geisler, Mars B. van t’ Veer, Jesper Jurlander, Jan Walewski, Geir Tjønnfjord, Maija Itälä Remes, Eva Kimby, Tomas Kozak, Aaron Polliack, Ka Lung Wu, Shulamiet Wittebol, Martine C. J. Abrahamse-Testroote, Jeanette Doorduijn, Wendimagegn Ghidey Alemayehu, Marinus H. J. van Oers
Journal: Blood (2014)
Intensive Insulin in Intensive Care
Authors: Atul Malhotra
Journal: New England Journal of Medicine (2006)

Among the critically ill, elevations in blood glucose, a marker previously ignored or described as adaptive, became a major therapeutic target after a 2001 study indicated a mortality benefit of intensive insulin therapy among patients in a surgical intensive care unit (ICU).1 Concern has arisen about that study because of the relatively high mortality in relation to the severity of illness among patients in the control group; the frequent administration of parenteral calories to critically ill patients, a practice that is uncommon at other centers; a preponderance of patients who had cardiac surgery in the single center where the study . . .