tbuckley/cabot-search huggingface dataset:
Abstract 668: DNA methylation of apoptosis-related genes as clinical biomarker in rectal cancer.
Authors: Anne Benard, Eliane C.M. Zeestraten, Inès J. Goossens-Beumer, Hein Putter, Christine Kuo, Cornelis J.H. van de Velde, Peter J.K. Kuppen, Dave S.B. Hoon
Journal: Cancer Research (2013)

Abstract Background: To prevent over- and undertreatment of rectal cancer patients, there is a need for the development of new biomarkers that can complement the current staging system. We have previously shown that apoptosis plays an important role in local tumor recurrence after TME surgery. We studied the epigenetic regulation of several key apoptosis genes in rectal cancer tissues, using methylation-sensitive restriction enzymes. Materials and methods: DNA was obtained from frozen specimens of 138 patients representative for the non-irradiated arm of the Dutch Total Mesorectal Excision (TME) trial. Isoschizomers HpaII (CpG methylation sensitive) and MspI (not sensitive) were used for restriction enzyme digestion of tumor DNA, followed by real-time PCR for apoptosis genes Apaf1, Bcl2, TrailR2, Fas and p53. A pilot series consisted of 50 patients with tumor stages I-III and 10 normal rectal tissues. For the validation study stage III patients (n=88) and 18 normal rectal tissues were selected. Results: Single marker analyses showed a significant correlation between methylation status and apoptotic status (measured by immunohistochemical staining of M30) of Fas (p=0.005) and Apaf1 (p=0.052). Combining intrinsic pathway markers Apaf1, Bcl2 and p53, significant differences were observed between the methylation groups in survival and recurrence analyses (log rank test), with overall survival (p=0.054), cancer specific survival (p=0.014) and distant recurrence free survival (p=0.006). Conclusion: Methylation of apoptosis genes is representative for the apoptotic status of a tumor and is correlated to survival and recurrence in rectal cancer patients. The apoptotic status of a tumor may be used to guide treatment strategies for individual patients. [A.B. and E.C.M.Z contributed equally to this work.] Citation Format: Anne Benard, Eliane C.M. Zeestraten, Inès J. Goossens-Beumer, Hein Putter, Christine Kuo, Cornelis J.H. van de Velde, Peter J.K. Kuppen, Dave S.B. Hoon. DNA methylation of apoptosis-related genes as clinical biomarker in rectal cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 668. doi:10.1158/1538-7445.AM2013-668
Sub-Urethral Tape Treatment of Female Urinary Incontinence?Morbidity Assessment of the Trans-Obturator Route and a New Tape (I-STOP): A Multi-Centre Experiment Involving 604 Cases
Authors: J KRAUTH, H RASOAMIARAMANANA, H BARLETTA, P BARRIER, M GRISARDANAF, J LIENHART, J MERMET, R VAUTHERIN, J FROBERT
Journal: European Urology (2004)
Upgrading V.D. departments.
Authors: A King
Journal: BMJ (1970)

BRNAL nearer to that of 15 mg. of morphine sulphate (11-4 mg. of anhydrous morphine).Our own studies* have shown that 13-3 mg. of morDhine sulohate contains the same amount of anhydrous morphine as 20 mg. of papaveretum, and that the effect of these two are indistinguishable clinically.-Weare, etc.,
Diagnosing COPD and targeted lung cancer screening: Figure 1–
Authors: Robert P. Young, Raewyn J. Hopkins
Journal: European Respiratory Journal (2012)

To the Editors:

We agree with Sekine et al . [1] and endorse their view that screening smokers for evidence of chronic obstructive pulmonary disease (COPD) will help identify those for who computed tomography (CT) screening for lung cancer is most appropriate [2]. We outline below further evidence supporting this viewpoint, specifically how the inclusion of COPD in screening eligibility might improve both sensitivity and specificity of CT screening for lung cancer.

With respect to sensitivity, current selection criteria for CT screening for lung cancer are limited to age and pack-yr exposure, despite this having poor predictive value [1]. If future CT screening is limited to those who meet the eligibility criteria used in the National Lung Screening Trial (NLST), we estimate only 47% of all lung cancers would be eligible for screening and over 50% of lung cancers will be missed [3]. Recent studies report that about 67% of lung cancer cases have underlying COPD based on spirometric criteria (Global Initiative for Chronic Obstructive Lung Disease (GOLD) 1+) [4, …
THE MANAGEMENT OF ACUTE THROMBOPHLEBITIC EDEMA
Authors: GÉZA de TAKÁTS
Journal: JAMA (1933)

The management of thrombophlebitic edema due to thrombosis of the deep veins usually consists of immobilization of the patient for from four to six weeks with some elevation of the affected limb. Then the patient is allowed to get up with or without elastic support and exhibits in most cases first a cyanotic, later a hard, brawny, swelling of the limb, which is permanent. Collateral veins do or do not appear on the extremity, according to the extent of thrombosis into the tributaries of the femoral vein. These chronic edemas are, aside from the cosmetic aspect, a potential source of further trouble. Superimposed ringworm infections, thrombophlebitic ulcers, and flareups of lymphangitis or of the old thrombophlebitis may lead to a state of elephantiasis (fig. 1). In extreme cases nothing short of an amputation helps. In the milder cases, the edema does not progress, but there remains a permanent, nonpitting edema
FAT NECROSIS FROM A SURGICAL STANDPOINT.
Authors: CARL BECK
Journal: JAMA (1901)

The information which we now possess in regard to fat necrosis is principally the result of the study of postmortem findings and extensive experimental work on the lower animals. On the living subject it was discovered but a limited number of times, during operations. The cases usually terminated fatally. Thus far only two cases have been recorded in the literature which recovered from this affection, although a great many cases might have recovered spontaneously without having been discovered. Having had the good fortune to observe a case which did not terminate fatally, I am prompted to publish my observations, trusting that my remarks will add some to the knowledge of this subject. The history of the case is as follows: Mrs. M. E., 26 years old, mother of two healthy children had always been in good health, with the exception of an attack of jaundice six years ago, which followed
A SIMPLE AID IN THE DIAGNOSIS OF SYPHILIS FROM THE PRIMARY LESION
Authors: William D. Gill
Journal: JAMA (1922)

A simple, efficient and easily made instrument which assists greatly in obtaining serum from the primary syphilitic lesion for dark field examination is pictured in the accompanying illustration. It consists of an ordinary all glass syringe of either 2, 5 or 10 cubic centimeter capacity, from which the tip and lowermost portion of the barrel are removed. This removal is accomplished by holding the tip of the syringe at a right angle against the side of a revolving emery wheel, and moistening the surface in contact with the wheel occasionally to diminish heating and insure a finer finish. Different sized instruments are advisable for use on lesions of varying magnitude. When the instrument is to be used, the suspected lesion is cleansed in the customary manner and the open end of the instrument placed over the ulcerated area, surrounding it like an inverted cup. Slow withdrawal of the piston results
Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney Disease
Authors: Arlene B. Chapman, David Rubinstein, Richard Hughes, John C. Stears, Michael P. Earnest, Ann M. Johnson, Patricia A. Gabow, William D. Kaehny
Journal: New England Journal of Medicine (1992)

Intracranial aneurysms are a feature of autosomal dominant polycystic kidney disease, but their prevalence is uncertain. We studied 92 subjects with autosomal dominant polycystic kidney disease who had no symptoms or signs of any neurologic disorder. To determine the prevalence of intracranial aneurysms, we performed high-resolution computed tomography (CT) in 60 subjects, four-vessel cerebral angiography in 21, and both procedures in 11.
SURGERY IN DERMATOLOGIC PRACTICE
Authors: GEORGE M. MacKEE
Journal: JAMA (1930)

Dermatology has evolved from a morphologic study of skin diseases and abnormalities, distinct from medicine and surgery, to the modern conception of cutaneous medicine in which the skin is considered as one of the important organs of the body in intimate physiologic relation with the general economy. This evolution has been accompanied by radical changes in diagnostic and therapeutic methods. The recognition of the relation of many morbid conditions in the skin to underlying disease processes necessitates the application and adaptation to dermatology of many of the modern diagnostic and therapeutic procedures developed in the fields of medicine and surgery during the dramatic scientific progress of the past few decades. It is therefore evident that the dermatologist of today should have a broad training in general medicine and surgery as a foundation for his special training. From the standpoint of therapy of many cutaneous conditions, surgery in its various forms
Managing tuberculosis and HIV infection.
Authors: M. Hickman, T. Ellam, S. Hargreaves, B. Gazzard, J. Porter
Journal: BMJ (1992)

The authors state that all the patients with the postviral fatigue syndrome had characteristic mitochondrial changes, and some had RNA enteroviral sequences, but as the necessary investigations were not applied to the depressed patients or controls it is not possible to tell whether these findings did in fact distinguish the group with the syndrome.Another issue that concerns us is that the authors fail to refer to the considerable body of work suggesting that release of prolactin mediated by 5-hydroxytryptamine is suppressed in depressed patients"4 and that this response is enhanced by antidepressant treatments, including electrocon- vulsive therapy.5There is a non-significant trend in their study for the depressed patients to have a smaller rise in prolactin secretion than controls, with the patients with the postviral fatigue syndrome having a significantly higher response than that of both the other groups.The finding that the prolactin response seems to be changed in opposite directions in the postviral fatigue syndrome and depression is of particular interest but makes it all the more frustrating that the clinical features of the two groups are not described more fully.Differences in neuroendocrine responses raise the possibility of subdividing poorly defined disease entities in a way that may better reflect underlying neuroendocrine disease, but to capitalise on this we need to know more about the correlations between these responses and individual symptoms.
Effect of Host Age on Tumor-Associated Angiogenesis in Mice
Authors: Regina A. Kreisle, Barbara A. Stebler, William B. Ershler
Journal: JNCI Journal of the National Cancer Institute (1990)

Previous reports on the slower growth of tumors in senescent mice have suggested a decrease in tumor angiogenesis in these animals, but such an observation has not yet been documented quantitatively. In this study, we report the relative amount of tumor angiogenesis and tumor volume for two different types of tumor in 11 young (8-9-wk old) versus nine older (19-mo old) male C57BL/10 mice. B16 melanoma or SP1 methylcholanthrene-induced fibrosarcoma cells were injected into the ventral skin of mice. After 3 days, the mice were killed and the injection sites were examined for angiogenesis surrounding the tumor (centrally directed tumor angiogenesis), nerve-associated angiogenesis, and tumor volume. In the older mice, there was significantly less centrally directed tumor angiogenesis for both tumors tested, and nerve-associated angiogenesis was decreased for B16 melanoma. The mean tumor volume for the B16 implants was smaller for the older animals, but the mean SP1 tumor volumes were identical for both age groups. These findings support the hypothesis that tumor growth in older animals is associated with less formation of new blood vessels, and this may explain the slower tumor growth observed in aged animals with certain experimental tumors.
85 Five years of sequential LAM TO LAM+ADV therapy suppresses HBV replication in most HBeAg-negative cirrhotics, preventing decompensation but not hepatocellular carcinoma
Authors: P. Lampertico, M. Viganò, E. Manenti, M. Iavarone, G. Lunghi, M. Colombo
Journal: Journal of Hepatology (2006)
State Dependence of Noise Correlations in Macaque Primary Visual Cortex
Authors: Alexander S. Ecker, Philipp Berens, R. James Cotton, Manivannan Subramaniyan, George H. Denfield, Cathryn R. Cadwell, Stelios M. Smirnakis, Matthias Bethge, Andreas S. Tolias
Journal: Neuron (2014)
Economic Evaluation of HIV Prevention Programs
Authors: David R. Holtgrave, Noreen L. Qualls, John D. Graham
Journal: Annual Review of Public Health (1996)

Program managers and policy makers need to balance the costs and benefits of various interventions when planning and evaluating HIV prevention programs. Resources to fund these programs are limited and must be used judiciously to maximize the number of HIV infections averted. Economic evaluation studies of HIV prevention interventions, which we review and critique here, can provide some of the needed information. Special emphasis is given to studies dealing with interventions to reduce or avoid HIV-related risk behaviors. Ninety-three cost-benefit, cost-effectiveness and cost-utility analyses were identified overall. However, only 28 dealt with domestic, behavior change interventions; the remainder focused on screening and testing without prevention counseling, and on care and treatment services. There are compelling demonstrations that behavioral interventions can be cost-effective and even cost-saving. The threshold conditions under which these programs can be considered cost-effective or cost-saving are well defined. However, several important intervention types and multiple key populations have been unstudied. Research in these areas is urgently needed.
Reducing Breast Cancer Risk
Authors: Joan Stephenson
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The CONSORT statement checklist in allergen‐specific immunotherapy: a GA<sup>2</sup>LEN paper
Authors: P. J. Bousquet, J. Brozek, C. Bachert, T. Bieber, S. Bonini, P. Burney, M. Calderon, G. W. Canonica, E. Compalati, J. P. Daures, L. Delgado, P. Demoly, R. Dahl, S. R. Durham, M. L. Kowalski, H. J. Malling, H. Merk, N. Papadopoulos, G. Passalacqua, H. U. Simon, M. Worms, U. Wahn, T. Zuberbier, H. J. Schünemann, J. Bousquet
Journal: Allergy (2009)

The methodology of randomized clinical trials is essential for the critical assessment and registration of therapeutic interventions. The CONSORT (Consolidated Standards of Reporting Trials) statement was developed to alleviate the problems arising from the inadequate reporting of randomized controlled trials. The present article reflects on the items that we believe should be included in the CONSORT checklist in the context of conducting and reporting trials in allergen‐specific immunotherapy. Only randomized, blinded (in particular blinding of patients, health care providers, and outcome assessors), placebo‐controlled Phase III studies in this article. Our analysis focuses on the definition of patients’ inclusion and exclusion criteria, allergen standardization, primary, secondary and exploratory outcomes, reporting of adverse events and analysis.
OCT Analysis in Patients With Very Late Stent Thrombosis
Authors: Soo-Jin Kang, Cheol Whan Lee, Haegeun Song, Jung-Min Ahn, Won-Jang Kim, Jong-Young Lee, Duk-Woo Park, Seung-Whan Lee, Young-Hak Kim, Gary S. Mintz, Seong-Wook Park, Seung-Jung Park
Journal: JACC. Cardiovascular imaging (2013)
Tamoxifen and Hypercalcemia
Authors: SALLY D. LANE
Journal: Annals of Internal Medicine (1980)

Letters1 April 1980Tamoxifen and HypercalcemiaSALLY D. LANE, M.D., EMMANUEL C. BESA, M.D., ROSALINE R. JOSEPH, M.D.SALLY D. LANE, M.D.Search for more papers by this author, EMMANUEL C. BESA, M.D.Search for more papers by this author, ROSALINE R. JOSEPH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-4-572_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The antiestrogen tamoxifen is frequently used in the treatment of metastatic breast cancer and has been considered relatively nontoxic. We wish to report two cases pertinent to this point.The first patient was a 48-year-old woman with breast cancer metastatic to bone. She was surgically post-menopausal, and estrogen receptors were positive in the primary tumor specimen. One week after beginning tamoxifen, 10 mg twice a day, serum calcium concentration rose from 9.9 mg/dL to 18.5 mg/dL. She was treated with saline hydration, intravenous furosemide, and mithramycin. Tamoxifen was discontinued. Serum calcium returned to normal within 3 days....References1. KIANGKENNEDY DB. Tamoxifen (antiestrogen) therapy in advanced breast cancer. Ann Intern Med. 1977;87:687-90. LinkGoogle Scholar2. PATTERSONFURRBATTERSBY JBL. Tamoxifen and hypercalcemia. Ann Intern Med. 1978;89:1013. Letter. LinkGoogle Scholar3. SPOONEREVANS DB. Tamoxifen and life-threatening hypercalcaemia. Lancet. 1979;2:413-4. Letter. CrossrefMedlineGoogle Scholar4. PLOTKINLECHNERJUNGROSEN DJWP. Tamoxifen flare in advanced breast cancer. JAMA 1978;240:2644-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medical College of Pennsylvania Philadelphia, PA 19129 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe pharmacology and clinical uses of tamoxifen 1 April 1980Volume 92, Issue 4Page: 572-573KeywordsAttentionBoneBreast cancerCalciumCancer treatmentEstrogensHypercalcemia Issue Published: 1 April 1980 PDF DownloadLoading ...
Guide to Clinical Trials
Authors: Sara E. Rosenbaum
Journal: JAMA (1993)

Bert Spilker's new text,Guide to Clinical Trials, is a combination of three of the author's previous books (Guide to Clinical Studies and Developing Protocols, Guide to Clinical Interpretation of Data, and Guide to Planning and Managing Multiple Clinical Studies) and 40 additional chapters. Potential readers who may be overwhelmed by a volume of this magnitude need only review any one of the 133 chapters to discover that the book is easy to read, very user friendly, and valuable as a reference text at the most basic level.  Guide to Clinical Trialsis a comprehensive, current, and thorough text, which covers virtually all aspects of the development, management, conduct, and interpretation of clinical trials. Additionally, although the major thrust is directed toward medicines, trials involving surgical procedures and medical devices are also discussed. Overall, this is a remarkable achievement for a single-author text, and this structure provides the qualities of
An Address ON RADIUM AND CANCER: Delivered at the Annual Meeting of the West Somerset Branch of the British Medical Association, at Taunton, on December 9th
Authors: A. P. Gould
Journal: BMJ (1914)

Ml'. PRESIDEN-T AND GENTLEMEN,-In speaking to youi this afternoon upon the subject of radium and cancer, a sub.ject clhosenl for ino by your President, I desire to keep steadilv before my mindi two or three facts whiclh make it imperative that 1 shlould spealk withi great reserve.Tie first of tlese 1acts is tlhatt familiar as we all are witl thle clinical imnifestations and the gross and the minute morbid anatomy cf malignant growtlhs, we are still ill ianiorance of their exact pathology.Wlhetlier cancer is the
Vincent Van Gogh And Glaucoma
Authors: H. Stanley Thompson
Journal: JAMA (1971)

<h3>To the Editor.—</h3> When you consider other liberties Van Gogh took with reality, the halos may not mean much. Any corneal clouding, such as corneal dystrophy, could have done the same thing. Van Gogh's liking for the southern parts of France did not have to be because his eyes were bad. People go to Miami Beach, Fla, in January because they like the warm sunshine, not to resolve eye problems. Gauguin liked it too, as did many other painters. As for the pupil, it tends to be dilated in angle closure glaucoma, which Van Gogh obviously did not have. He might have had an Adie's tonic pupil, but more likely the anisocoria was a slip of the brush. I think the case for glaucoma a bit weak, but I am also bothered by that "uncontroversial piece of accumulated evidence," which might have been incontrovertible, and by the loan of "credulity
DIRECT VISION ADENOTOME
Authors: I. D. Kelley
Journal: JAMA (1922)

Working on the assumption that the existing method of adenoid removal with the instruments thus far devised is unsurgical, because of the fact that to carry out this operation the operative field has not been in the direct line of vision of the operator, I investigated thoroughly the postnasal space. I found it possible to construct an instrument that would not only remove the adenoid as completely as any instrument thus far devised, but also bring the adenoid area in direct vision of the operator previous to and at the time of removal, and do away with the untoward results in previously devised operations, such as blind technic, stripping of the posterior pharyngeal wall, partial adenoid removal, and loss of the removed adenoid.  The principles which this instrument employs are (1) elevation of the soft palate by the oral route sufficient to expose to view the circumference of the posterior
Sudden infant death syndrome in Hong Kong
Authors: E. Lau
Journal: BMJ (1989)

this will generally be detectable within a few months afterwards by conventional testing for antibody."-ED,BMJ.Sudden infant death syndrome in Hong Kong SIR,-Dr Millard Bass, commenting on our paper on sudden infant death syndrome in Hong Kong,' wrongly asserted that the controls we used were unsuitable.2According to basic epidemiological principles, controls should not have the disease or condition under investigation but should be similar to cases in regard to past potential for exposure.We used one community control and one hospital control for each dead child, and we consider that neither group was subject to selection bias.The controls