tbuckley/cabot-search huggingface dataset:
Perspectives of Sociotherapy
Authors: E.A.D.E. Carp
Journal: Psychotherapy and Psychosomatics (1955)

Research Articles| January 20 2010 Perspectives of Sociotherapy Subject Area: Psychiatry and Psychology E.A.D.E. Carp E.A.D.E. Carp Leyden Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1955) 3 (4): 335–341. https://doi.org/10.1159/000278500 Article history Published Online: January 20 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation E.A.D.E. Carp; Perspectives of Sociotherapy. Acta Psychotherapeutica et Psychosomatica 1 April 1955; 3 (4): 335–341. https://doi.org/10.1159/000278500 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1955Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Evaluation of Potential Infectivity of Alzheimer and Parkinson Disease Proteins in Recipients of Cadaver-Derived Human Growth Hormone
Authors: David J. Irwin, Joseph Y. Abrams, Lawrence B. Schonberger, Ellen Werber Leschek, James L. Mills, Virginia M.-Y. Lee, John Q. Trojanowski
Journal: JAMA Neurology (2013)

Growing evidence of cell-to-cell transmission of neurodegenerative disease (ND)-associated proteins (NDAPs) (ie, tau, Aβ, and α-synuclein) suggests possible similarities to the infectious prion protein (PrPsc) in spongiform encephalopathies. There are limited data on the potential human-to-human transmission of NDAPs associated with Alzheimer disease (AD) and other non-PrPsc ND.To examine evidence for human-to-human transmission of AD, Parkinson disease (PD), and related NDAPs in cadaveric human growth hormone (c-hGH) recipients.We conducted a detailed immunohistochemical analysis of pathological NDAPs other than PrPsc in human pituitary glands. We also searched for ND in recipients of pituitary-derived c-hGH by reviewing the National Hormone and Pituitary Program (NHPP) cohort database and medical literature.University-based academic center and agencies of the US Department of Health and Human Services.Thirty-four routine autopsy subjects (10 non-ND controls and 24 patients with ND) and a US cohort of c-hGH recipients in the NHPP.Detectable NDAPs in human pituitary sections and death certificate reports of non-PrPsc ND in the NHPP database.We found mild amounts of pathological tau, Aβ, and α-synuclein deposits in the adeno/neurohypophysis of patients with ND and control patients. No cases of AD or PD were identified, and 3 deaths attributed to amyotrophic lateral sclerosis (ALS) were found among US NHPP c-hGH recipients, including 2 of the 796 decedents in the originally confirmed NHPP c-hGH cohort database.Despite the likely frequent exposure of c-hGH recipients to NDAPs, and their markedly elevated risk of PrPsc-related disease, this population of NHPP c-hGH recipients does not appear to be at increased risk of AD or PD. We discovered 3 ALS cases of unclear significance among US c-hGH recipients despite the absence of pathological deposits of ALS-associated proteins (TDP-43, FUS, and ubiquilin) in human pituitary glands. In this unique in vivo model of human-to-human transmission, we found no evidence to support concerns that NDAPs underlying AD and PD transmit disease in humans despite evidence of their cell-to-cell transmission in model systems of these disorders. Further monitoring is required to confirm these conclusions.
Experimental Production of Human "Blue Velvet" and "Red Devil" Lesions
Authors: Henry E. Puro
Journal: JAMA (1966)

ONE of the medical complications of the intravenous use of narcotics by addicts is the development of pulmonary hypertension due to arteritis and thrombosis of small pulmonary arteries, arterioles, and capillaries. We recently reported such a case in which a 32-year-old Negro woman with cor pulmonale died of severe pulmonary hypertension.<sup>1</sup>The pulmonary vessels showed thrombosis of varying duration. Many crystalline foreign bodies, identified as talc crystals, were found in the pulmonary vessels. The patient was a narcotic mainliner who had been injecting herself with a mixture known as "blue velvet" consisting of concentrated paregoric to which had been added a crushed tripelennamine (pryribenzamine) hydrochloride tablet. The offending agent was identified as talc in the tripelennamine tablet. We have recently observed "red devil" addiction in the Detroit area. This type of addiction consists of injecting the contents of secobarbital (Seconal) capsules intravenously. In this form of addiction starch from
Autoantibodies in Sporadic Creutzfeldt-Jakob Disease
Authors: Heather Angus-Leppan, Peter Rudge, Simon Mead, John Collinge, Angela Vincent
Journal: JAMA Neurology (2013)

The diagnosis of autoimmune and neurodegenerative conditions can be unclear. Treatments such as removing the associated tumor, if present, and immunosuppression can halt or often reverse the progression of autoimmune conditions, but there is no curative treatment for neurodegenerative conditions. The presence of autoantibodies can sometimes be misleading. This report illustrates potential difficulties in differentiating autoimmune encephalopathies from sporadic Creutzfeldt-Jakob disease.
Evidence based case report: Assessing developmental delay
Authors: J. Dorling, A. Salt
Journal: BMJ (2001)

An 18 month old boy was referred to the local child development centre because he was not walking independently. He walked around by holding on to furniture; he had first crawled at age 11 months.

We wanted to use an evidence based approach to guide our assessment and management, so before seeing him, we considered three issues. Firstly, we wanted to know whether, in an 18 month old child referred to a community paediatrician because he cannot walk independently, the most likely outcome is cerebral palsy, a primary muscle disorder, another neurological abnormality, or simply delayed motor development. Secondly, we wanted to know how many children with Duchenne muscular dystrophy present with delayed walking at 18 months. Thirdly, we wanted to know whether a creatine kinase level is a worthwhile screening test if there are no abnormal signs.

To determine the most likely outcome, we used a Medline database to obtain evidence (at http://biomed.niss.ac.uk/). We used a filter to select articles dealing with prognosis (from wwwlib.jr2.ox.ac.uk/caspfew/filters/). We found additional papers by using the exploded form of “prognosis” (“exp prognosis”) instead of the text word. We combined …
Impairment of Endothelial Functions by Acute Hyperhomocysteinemia and Reversal by Antioxidant Vitamins
Authors: Francesco Nappo
Journal: JAMA (1999)

Increased levels of homocysteine are associated with risk of cardiovascular disease. Homocysteine may cause this risk by impairing endothelial cell function.To evaluate the effect of acute hyperhomocysteinemia with and without antioxidant vitamin pretreatment on cardiovascular risk factors and endothelial functions.Observer-blinded, randomized crossover study conducted at a university hospital in Italy.Twenty healthy hospital staff volunteers (10 men, 10 women) aged 25 to 45 years.Subjects were given each of 3 loads in random order at 1-week intervals: oral methionine, 100 mg/kg in fruit juice; the same methionine load immediately following ingestion of antioxidant vitamin E, 800 IU, and ascorbic acid, 1000 mg; and methionine-free fruit juice (placebo). Ten of the 20 subjects also ingested a placebo load with vitamins.Lipid, coagulation, glucose, and circulating adhesion molecule parameters, blood pressure, and endothelial functions as assessed by hemodynamic and rheologic responses to L-arginine, evaluated at baseline and 4 hours following ingestion of the loads.The oral methionine load increased mean (SD) plasma homocysteine level from 10.5 (3.8) micromol/L at baseline to 27.1 (6.7) micromol/L at 4 hours (P<.001). A similar increase was observed with the same load plus vitamins (10.0 [4.0] to 22.7 [7.8] micromol/L; P<.001) but no significant increase was observed with placebo (10.1 [3.7] to 10.4 [3.2] micromol/L; P=.75). Coagulation and circulating adhesion molecule levels significantly increased after methionine ingestion alone (P<.05) but not after placebo or methionine ingestion with vitamins. While the mean (SD) blood pressure (-7.0% [2.7%]; P<.001), platelet aggregation response to adenosine diphosphate (-11.4% [4.5%]; P=.009) and blood viscosity (-3.0% [1.2%]; P=.04) declined in these parameters 10 minutes after an L-arginine load (3 g) following placebo, the increase after methionine alone (-2.3% [1.5%], 4.0% [3.0%], and 1.5% [1.0%], respectively; P<.05), did not occur following methionine load with vitamin pretreatment (-6.3% [2.5%], -7.9% [3.5%], and -1.5% [1.0%], respectively; P=.24).Our data suggest that mild to moderate elevations of plasma homocysteine levels in healthy subjects activate coagulation, modify the adhesive properties of endothelium, and impair the vascular responses to L-arginine. Pretreatment with antioxidant vitamin E and ascorbic acid blocks the effects of hyperhomocysteinemia, suggesting an oxidative mechanism.
CD69 upregulation on T cells as an <i>in vitro</i> marker for delayed‐type drug hypersensitivity
Authors: A. Beeler, L. Zaccaria, T. Kawabata, B. O. Gerber, W. J. Pichler
Journal: Allergy (2007)

T cells play a key role in delayed-type drug hypersensitivity reactions. Their reactivity can be assessed by their proliferation in response to the drug in the lymphocyte transformation test (LTT). However, the LTT imposes limitations in terms of practicability, and an alternative method that is easier to implement than the LTT would be desirable.Four months to 12 years after acute drug hypersensitivity reactions, CD69 upregulation on T cells of 15 patients and five healthy controls was analyzed by flow cytometry.All 15 LTT-positive patients showed a significant increase of CD69 expression on T cells after 48 h of drug-stimulation exclusively with the drugs incriminated in drug-hypersensitivities. A stimulation index of 2 as cut-off value allowed discrimination between nonreactive and reactive T cells in LTT and CD69 upregulation. T cells (0.5-3%) showed CD69 up-regulation. The reactive cell population consisted of a minority of truly drug reactive T cells secreting cytokines and a higher number of bystander T cells activated by IL-2 and possibly other cytokines.CD69 upregulation was observed after 2 days in all patients with a positive LTT after 6 days, thus appearing to be a promising tool to identify drug-reactive T cells in the peripheral blood of patients with drug-hypersensitivity reactions.
Immunological characteristics of gonococcal outer membrane protein II assessed by immunoprecipitation, immunoblotting, and coagglutination.
Authors: J Swanson, O Barrera
Journal: The Journal of Experimental Medicine (1983)

Immunoprecipitation or coagglutination with whole gonococci and immunoblotting have been used to assess the comparative antigenicities of 11 different protein II (P.II) moieties from four different strains. Rabbit antisera used for these studies include both anti-whole gonococcal sera and antisera raised by immunization with "isolated" P.II preparations. The results show that: (a) immunization with gonococci possessing a single P.II elicits formation of antibodies directed mainly at the homologous P.II when assessed by either immunoprecipitation or immunoblotting; and (b) immunization with isolated P.II material elicits formation of antibodies that are cross-reactive with all (or nearly all) P.II species in immunoblots; these antibodies recognize mainly the homologous P.II by immunoprecipitation. These results have been interpreted as showing the following: (a) all gonococcal outer membrane P.II moieties share antigenic determiners, but these common antigens are not generally accessible on the organisms' surfaces for interaction with antibody molecules; and (b) the surface-exposed antigens of different P.II constituents are, in general, different from one another.
Regulation of the rabbit ileal brush-border Na+/H+ exchanger by an ATP-requiring Ca++/calmodulin-mediated process.
Authors: R P Rood, E Emmer, J Wesolek, J McCullen, Z Husain, M E Cohen, R S Braithwaite, H Murer, G W Sharp, M Donowitz
Journal: Journal of Clinical Investigation (1988)

Brush-border vesicles purified from rabbit ileal villus cells were used to evaluate how Ca++/calmodulin (CaM) regulates the neutral linked NaCl absorptive process, part of which is a Na+/H+ exchanger. After freezing and thawing to allow incorporation of macromolecules into the vesicles, the effect of Ca++/CaM on brush-border Na+ uptake with an acid inside pH gradient, and on Na+/H+ exchange was determined. Freezing and thawing vesicles with 0.85 microM free Ca++ plus 5 microM exogenous CaM failed to alter Na+/H+ exchange as did the addition of exogenous ATP plus an ATP regenerating system, which was sufficient to elevate intravesicular ATP to 47 microM from a basal level of 0.4 microM. However, the combination of Ca++/CaM plus ATP inhibited Na+ uptake in the presence of an acid inside pH gradient and inhibited Na+/H+ exchange, while Na+ uptake in the absence of a pH gradient was not altered. This effect required a hydrolyzable form of ATP, and did not occur when the nonhydrolyzable ATP analogue, AMP-PNP, replaced ATP. Under the identical intravesicular conditions used for the transport studies, Ca++ (0.85 microM) plus exogenous CaM (5 microM), in the presence of magnesium plus ATP, increased phosphorylation of five brush-border peptides. These data are consistent with Ca++/CaM acting via phosphorylation to regulate the ileal brush-border Na+/H+ exchanger.
Loss of the SMRT/NCoR2 Corepressor Correlates with JAG2 Overexpression in Multiple Myeloma
Authors: Pushpankur Ghoshal, Alain J. Nganga, Joseph Moran-Giuati, Angela Szafranek, Timothy R. Johnson, Ashley J. Bigelow, Christiane M. Houde, Herve Avet-Loiseau, Dominic J. Smiraglia, Noreen Ersing, Asher A. Chanan-Khan, Lionel J. Coignet
Journal: Cancer Research (2009)

Multiple myeloma (MM) is a clonal B-cell neoplasm that accounts for 10% of all malignant hematologic neoplasms and that affects terminally differentiated B cells (i.e., plasma cells). It is now well recognized that the cytokine interleukin-6 (IL-6) is a major cytokine that promotes the proliferation of malignant plasma cells in MM. The IL-6 gene can be regulated by the NOTCH genes products. We have previously shown that the NOTCH ligand, JAG2, is overexpressed in MM. To investigate the mechanism(s) leading to JAG2 overexpression in MM, we assessed potential epigenetic modifications of the JAG2 promoter. We showed that the JAG2 promoter region is aberrantly acetylated in MM cell lines and patient samples. The acetylation state of histones is regulated by the recruitment of histone deacetylases (HDAC). HDACs are typically recruited to promoter regions through interaction with nuclear corepressors such as SMRT. SMRT levels were therefore investigated. Interestingly, MM cell lines and patient samples presented significantly reduced SMRT levels. The experiments suggest a correlation between constitutive acetylation of the JAG2 core promoter in the MM cell lines and reduced levels of the SMRT corepressor that recruits HDAC to promoter regions. Finally, SMRT function restoration induced JAG2 down-regulation as well as MM cell apoptosis.
Human eosinophil granule major basic protein and its novel homolog
Authors: D. A. Plager, S. Stuad, G.J. Gleich
Journal: Allergy (1998)

Human MBP is associated with an array of in vitro cytotoxic and cytostimulatory activities, mediated in part by its strong basicity. It is most prominently found in the eosinophil, but is also present in placental X cells and placental-site giant cells during pregnancy. Pathologically, its pattern of tissue deposition and its ability to induce characteristic pathophysiologic changes, such as bronchial hyperreactivity and vasopermeability, strongly suggest a role for MBP in allergic and eosinophilic diseases. The role of MBP in protection from helminthic disease is also evident. Here, we present information on a novel homolog of eosinophil granule MBP with biologic activities similar to that of MBP. However, results from experiments on eosinophil granules suggest that the quantity of the homolog present in the eosinophil granule is significantly less than that of MBP itself. Further, preliminary experiments indicate that the two proteins are not synergistic in terms of their cytotoxic and cytostimulatory biologic activities. Future experiments must determine whether the MBP homolog is deposited at sites of tissue damage and can be detected in biologic fluids at concentrations required for biologic activity.
Contribution of Intravascular Receptors to the Renal Responses Following Intravascular Volume Expansion
Authors: JOSEPH P. GILMORE, MYRON L. WEISFELDT
Journal: Circulation Research (1965)

The renal responses to acute isotonic, isooncotic intravascular volume expansion have been studied in the normal dog, the vagotomized dog, and the dog with carotid sinus denervation. It was observed that either vagotomy or carotid sinus denervation attenuates significantly the diuretic response to intravascular volume expansion without influencing significantly the natriuretic response. The results indicated that carotid sinus receptors and receptors which have afferent fibers in the vagus nerves contribute substantially to the control of plasma volume by a mechanism which influences free water excretion. The receptors of the low pressure system probably play a primary role under conditions of hypervolemia while receptors of the high pressure system appear to play a primary role under conditions of hypovolemia.
Reduced Serum Levels of Innate Immune Molecules in Subjects with Frequent Asthma Exacerbations
Authors: E.T. Gardner, C. Sheen, L.M. Stierman, B. Jovanovic, J.J. Shannon, C.A. Saltoun, L.C. Grammer, R.P. Schleimer
Journal: Journal of Allergy and Clinical Immunology (2006)
Graham Herbert Anderson
Authors: John H Chippendale
Journal: BMJ (2006)

​FormerFormer general practitioner Lancaster (b 1918; q Glasgow 1940; FRCP Glas, FRCGP), died from a stroke on 4 March 2006.




Figure 1




Graham Anderson saw war service with the Royal Air Force Flying Training Command. In 1948 he took up a locum post in Lancaster, staying on to be a partner for 32 years and senior partner for 17. He was a founder member of the Royal College of General Practitioners, becoming a fellow and gold medallist. He was a trainer in general practice and clinical assistant in neurosurgery and electroencephalography, as well as active in the Lancaster Medical Book Club and Lancaster division of the BMA. He leaves a wife, Barbara; two children; and two grandchildren.
207 BLOCKING THE HEDGEHOG PATHWAY ATTENUATES CARCINOGENESIS OF CHOLANGIOCELLULAR CARCINOMA
Authors: M. El Khatib, A. Kalnytska, V. Palagani, L. Wilkens, M.P. Manns, N.P. Malek, R.R. Plentz
Journal: Journal of Hepatology (2011)
There's No Place Like Home: The Home Health Care Alternative
Authors: Linda Gundersen
Journal: Annals of Internal Medicine (1999)

Currents19 October 1999There's No Place Like Home: The Home Health Care AlternativeLinda GundersenLinda GundersenSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-8-199910190-00103 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail As managed care attempts to deal with increasing medical costs, home care has emerged as a popular alternative for patient treatment. Because home care (which is one of the fastest-growing segments of the U.S. health care structure) often substitutes for inpatient treatment, some view it as a cost-cutting method that is good for the short term but may be more expensive over time. Home health care is a “hot trend,” according to the Trends Research Institute, Rhinebeck, New York, and a closer look at its efficacy and long-term cost-effectiveness is therefore essential.The History of Home Health CareFor thousands ... Author, Article, and Disclosure InformationAuthors: Linda Gundersen PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRehabilitation: sectorial interventionsBack homeMEDICAL DEVICESA new model of integrated home care for the elderly 19 October 1999Volume 131, Issue 8Page: 639-640KeywordsCaregiversElderlyHealth careInpatientsMedical servicesMedicareNursing homesPatientsPneumoniaPrevention, policy, and public health ePublished: 15 August 2000 Issue Published: 19 October 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.Loading ...