tbuckley/cabot-search huggingface dataset:
Angiotensin-Converting Enzyme Inhibitors and Chyluria
Authors: Alejandro E. C. Saleh
Journal: Annals of Internal Medicine (1993)

Letters15 December 1993Angiotensin-Converting Enzyme Inhibitors and ChyluriaAlejandro E. C. Saleh, MDAlejandro E. C. Saleh, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-12-199312150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest the article by Keilani and colleagues [1], showing improvement of lipid abnormalities associated with proteinuria using the Angiotensin-converting enzyme (ACE) inhibitor fosinopril. It prompted me to describe the following patient. A 60-year-old woman had developed, 15 years earlier in Surinam, a filarial infection of the left leg. She was treated and recovered. In 1990, her urine became milky, and she was diagnosed as having chyluria secondary to the filarial infection. Several kinds of medication had been used unsuccessfully.She was seen in September 1992 for the same problem. The results of her physical ...References1. Keilani T, Schlueter WA, Levin ML, Batlle DC. Improvement of lipid abnormalities associated with proteinuria using fosinopril, an angiotensin-converting enzyme inhibitor. Ann Intern Med. 1993; 118:246-54. Google Scholar2. Schleuter WA, Batlle DC. Renal effects of antihypertensive drugs. Drugs. 1989; 37:900-25. Google Scholar3. Meyer TW, Anderson S, Rennke HG, Brenner BM. Reversing glomerular hypertension stabilizes established glomerular injury. Kidney Int. 1987; 31:752-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHIFU, a noninvasive and effective treatment for chyluria: 15 years of experienceChyluria in non-filarial endemic areas: an internist's perspectiveChyluria: a mimicker of nephrotic syndromeChyluria Associated with Nephrotic-Range Proteinuria: Pathophysiology, Clinical Picture and Therapeutic OptionsA rare case of milky urineChyluria with proteinuria or filarial nephropathy? An enigma 15 December 1993Volume 119, Issue 12Page: 1223-1224KeywordsACE inhibitorsAttentionCholesterolCreatinineLymphProteinsProteinuriaResearch laboratoriesSerum albuminUrine Issue Published: 15 December 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Care and Management of Neonates with Severe Cyanosis
Authors: L. Jerome Krovetz
Journal: New England Journal of Medicine (1971)

The young heart patient with marked cyanosis and other cardiorespiratory difficulties in the neonatal period has a poor prognosis indeed. The majority of such neonates with severe cyanosis progress to an inexorable course of progressive acidosis, increasing cardiac decompensation, further cyanosis and death unless vigorous efforts are made at diagnosis, medical therapy and surgical intervention.Until very recently there was some understandable reluctance to follow a course of vigorous medical therapy since the results of surgery in the first few weeks of life were rather discouraging. One group had advocated omission of the diagnostic catheterization and angiocardiography whenever the clinical . . .
Neonatal prevention ofiron deficiency
Authors: A. Pisacane
Journal: BMJ (1996)

into individual cases.One approach would be to bring techniques from qualitative research6 to bear on the process of implementation, collation, and dissemination of results.Secondly, it should broaden its perspective.We need to know about all homicides committed by the mentally abnormal and not just a selected subgroup.The government white paper, The Health of the Nation, sets targets for suicide prevention in those with severe mental illness7; this is not synonymous with contact with the psychiatric services.Jayne Zito's remarkable response to her husband's murder by Christopher Clunis, who suffered from schizophrenia, should inspire us to make much more effort than we do to obtain systematic information and opinions from relatives-of victims of homicide, of mentally abnormal offenders, and of suicides.Thirdly, the inquiry needs to adopt more rigorous investigative methods.Risk factors for violent death can be identified only by more rigorous use of techniques such as case control studies and case ascertainment and data collection can be comprehensive and unbiased only if they are not left to the discretion of clinicians.
Co-trimoxazole in rheumatoid arthritis: a comparison with sulphapyridine.
Authors: C Astbury, J Hill, H A Bird
Journal: Annals of the Rheumatic Diseases (1988)

The antirheumatoid activity of sulphasalazine and sulphapyridine may result from their antibacterial properties. The second line activity of sulphamethoxazole, in the form of cotrimoxazole (CTZ), has been investigated by treatment of 13 patients with RA for 24 weeks with CTZ (480 mg three times a day). The drug was found to be poorly tolerated, only five of the thirteen patients recruited completing the study. High circulating concentrations of sulphamethoxazole were found, with mean (SD) steady state serum concentrations reaching 54.02 (23.38) micrograms/ml. A significant reduction in serum IgM from 280 to 130 IU/l was observed, but otherwise disease activity remained unchanged or deteriorated throughout the course of the study. In contrast, patients with RA treated with sulphapyridine (1.25 g a day) showed improvement in disease activity. The results argue against an antibacterial mechanism of action for sulphasalazine and sulphapyridine in rheumatoid arthritis, unless this occurs at a site inaccessible to sulphamethoxazole.
Low molecular weight heparin decreases rebound ischemia in unstable angina or non-Q-wave myocardial infarction: the Canadian ESSENCE ST segment monitoring substudy
Authors: Shaun G Goodman, Aiala Barr, Anatoli Sobtchouk, Marc Cohen, Gregg J Fromell, Luc Laperrière, Carol Hill, Anatoly Langer
Journal: Journal of the American College of Cardiology (2000)
Effects of pluronic and doxorubicin on drug uptake, cellular metabolism, apoptosis and tumor inhibition in animal models of MDR cancers
Authors: Elena V. Batrakova, Shu Li, Anna M. Brynskikh, Amit K. Sharma, Yili Li, Michael Boska, Nan Gong, R. Lee Mosley, Valery Yu. Alakhov, Howard E. Gendelman
Journal: Journal of Controlled Release (2010)
Obama challenges Republicans to offer alternatives to health act
Authors: M. McCarthy
Journal: BMJ (2014)

President Barack Obama used his annual State of the Union address to Congress to tout the successes of the Affordable Care Act and challenge Congressional Republicans to present their alternatives to the law, which they have voted more than 40 times to repeal since it passed in 2010.

Since the health insurance marketplaces opened last October, more than nine million people had obtained either private insurance or Medicaid coverage, he noted. He also pointed out that under the law no one …
Royal College of Surgeons in Ireland (RCSI) replies to Fiona Godlee
Authors: E. McGovern, C. J. Kelly
Journal: BMJ (2011)

Fiona Godlee challenges the Royal College of Surgeons in Ireland (RCSI) in relation to the detention and trial of healthcare professionals in Bahrain.1 We here clarify our position on this issue.

RCSI is a not for profit medical educational institution that has consistently espoused the fundamental principles of independence and non-discrimination in providing medical care to patients, advancing healthcare in the Republic of Ireland and elsewhere, and educating healthcare professionals to the highest ethical and professional standards. Such ethical principles inform all our actions everywhere.

With regard to the current situation in Bahrain, we welcome the Bahraini authorities’ decision on 5 October 2011 to set aside the verdicts of the military court, as well as the announcement that the accused healthcare professionals will be retried in civilian courts …
Consensus and Update on the Definition of On-Treatment Platelet Reactivity to Adenosine Diphosphate Associated With Ischemia and Bleeding
Authors: Udaya S. Tantry, Laurent Bonello, Daniel Aradi, Matthew J. Price, Young-Hoon Jeong, Dominick J. Angiolillo, Gregg W. Stone, Nick Curzen, Tobias Geisler, Jurrien ten Berg, Ajay Kirtane, Jolanta Siller-Matula, Elisabeth Mahla, Richard C. Becker, Deepak L. Bhatt, Ron Waksman, Sunil V. Rao, Dimitrios Alexopoulos, Rossella Marcucci, Jean-Luc Reny, Dietmar Trenk, Dirk Sibbing, Paul A. Gurbel
Journal: Journal of the American College of Cardiology (2013)
Hemoglobin A1c Compared with Three Conventional Measures of Diabetes Control
Authors: Marc H Blanc, Donald M Barnett, Ray E Gleason, Peter J Dunn, J Stuart Soeldner
Journal: Diabetes Care (1981)

Control of diabetes was studied during an 8-wk camp program in 18 insulin-dependent counselors with a mean age of 19.3 yr and a mean duration of diabetes of 11.4 yr. A composite score was obtained for each subject derived from three factors: percent sugar-free urine tests, 24-h glucose excretion as percent of carbohydrate intake, and mean preprandial blood glucose (MPBG). The mean hemoglobin A1c (HbA1c) at the end of the period was 8.3 ± 1.6% (± SD) (normal range, 4–6%). Scores ranging from 24 (fair control) to 45 (excellent control) showed a significant inverse correlation with HbA1c (r = – 0.807, P &amp;lt; 0.001) and MPBG (r = – −0.674, P &amp;lt; 0.01). HbA1c showed a significant correlation with the MPBG (r = 0.693, P &amp;lt; 0.01). The HbA1c level was predicted better by percent sugar-free urine tests than by the 24-h glucose excretion. Thus it appears that accurate quantification of control may be obtained by using a scoring system. Critical comparison of HbA1c levels to various glycemic indices may provide useful alternatives for estimating diabetes control.
Midwifery and quality care: findings from a new evidence-informed framework for maternal and newborn care
Authors: Mary J Renfrew, Alison McFadden, Maria Helena Bastos, James Campbell, Andrew Amos Channon, Ngai Fen Cheung, Deborah Rachel Audebert Delage Silva, Soo Downe, Holly Powell Kennedy, Address Malata, Felicia McCormick, Laura Wick, Eugene Declercq
Journal: The Lancet (2014)
CS gas has been used as chemical restraint in mentally ill person
Authors: P. Trigwell
Journal: BMJ (1997)

Editor–An event that occurred recently while I was on call as a senior registrar in psychiatry in Leeds has prompted me to become concerned about the use of CS gas by the police. An inpatient on a neurology ward in a general hospital had become suddenly and unexpectedly violent, causing injuries to hospital staff. The episode could not be contained on the ward, and so the police were called. The patient was taken to a nearby police station, and I was asked to assess his …
Well-aligned chitosan-based ultrafine fibers committed teno-lineage differentiation of human induced pluripotent stem cells for Achilles tendon regeneration
Authors: Can Zhang, Huihua Yuan, Huanhuan Liu, Xiao Chen, Ping Lu, Ting Zhu, Long Yang, Zi Yin, Boon Chin Heng, Yanzhong Zhang, Hongwei Ouyang
Journal: Biomaterials (2015)
Low Plasma Adiponectin Levels Are Associated With Increased Hepatic Lipase Activity In Vivo
Authors: Junji Kobayashi, Yuko Murase, Masa-aki Kawashiri, Atsushi Nohara, Akihiro Inazu, Hiroshi Mabuchi
Journal: Diabetes Care (2006)

Recently, close attention has been given to the relationships between plasma adiponectin levels and lipolytic enzymes such as hepatic lipase and lipoprotein lipase activities in an effort to understand the possible mechanism of hyperlipidemia in low adiponectin. The cross-sectional study by Schneider et al. (1) has concluded that postheparin plasma hepatic lipase activity is inversely associated with plasma …
Dasatinib induces durable cytogenetic responses in patients with chronic myelogenous leukemia in chronic phase with resistance or intolerance to imatinib
Authors: A Hochhaus, M Baccarani, M Deininger, J F Apperley, J H Lipton, S L Goldberg, S Corm, N P Shah, F Cervantes, R T Silver, D Niederwieser, R M Stone, H Dombret, R A Larson, L Roy, T Hughes, M C Müller, R Ezzeddine, A M Countouriotis, H M Kantarjian
Journal: Leukemia (2008)
Exhaled nitric oxide as a marker of airway inflammation for an epidemiologic study in schoolchildren
Authors: Junpei Saito, Keiichi Inoue, Aya Sugawara, Motoko Yoshikawa, Kana Watanabe, Takashi Ishida, Yoshinori Ohtsuka, Mitsuru Munakata
Journal: Journal of Allergy and Clinical Immunology (2004)
There is no evidentiary silver bullet for the frequency adaptation hypothesis
Authors: Gary L. Brase
Journal: Behavioral and Brain Sciences (2002)

Special design criteria are largely unable to discriminate between claims that specific competencies in judgements under uncertainty are a result of an adaptation for representing naturally sampled frequencies, or due only to inherent properties of such a format. Because divisions between these perspectives are thin, evidence via additional criteria are persuasive only in combination, using inference to the best available explanation.
Cancer of the Gastrointestinal Tract
Authors: Philip Rubin
Journal: JAMA (1974)

Advances in surgical and radiotherapeutic techniques have not altered the survival figures of esophageal cancers. The ability of surgeons to resect the entire esophagus and to reconstruct an alimentary channel has increased the operability and resectability rates, but not the survival rate. The introduction of supervoltage irradiation has led to aggressive treatment of this cancer with high-energy beams and high doses, but again, gains in survival have been small. A survey of the world literature for five-year survivors can best be described as pitiful. Only 135 survivors were noted by Smithers in 1957<sup>1</sup>at the time of the survey. In their offering in this series, Nakayama and Kinoshita reported only 301 five-year survivors in all the surgical literature. The concepts of operability and resectability in esophageal cancer have undergone considerable change; now surgery is performed for palliation even if the patient's prognosis is bleak. The lack of a generally
ABC of sexual health: Sexual problems of disabled patients
Authors: C. Glass, B. Soni
Journal: BMJ (1999)

Almost 4% of the UK population have some form of physical, sensory, or intellectual impairment—almost 2.5 million people. Many of these disabling conditions can produce sexual problems of desire, arousal, orgasm, or sexual pain in men and women. Sexual difficulties may arise from direct trauma to the genital area (due to either accident or disease), damage to the nervous system (such as spinal cord injury), or as an indirect consequence of a non-sexual illness (cancer of any organ may not directly affect sexual abilities but can cause fatigue and reduce the desire or ability to engage in sexual activity). The two main points for consideration are how disabling conditions affect sexual function and behaviour and which sexual difficulties most commonly arise. Women who undergo radical mastectomy or a disfiguring trauma often report concerns about their femininity and self image such as feelings of lowered self worth or the fear that men will find them less attractive. Similarly, young men with erectile dysfunction often avoid meeting potential partners because of their embarrassment over their inability to perform. "Sexuality" describes how people express their view of what is sexual. That awareness is the result of all the physical, emotional, intellectual, and social factors that have influenced their development up to that point in their life. Defining sexuality as wider than just physical functionis particularly important for people with disabilities. A person who is not able to use part of his or her body still has an equal right to full sexual expression. ### Key questions in cases of disability Present condition Effect of condition on sexuality
Psychoanalysis, psychotherapy, and health services.
Authors: M Shepherd
Journal: BMJ (1979)

In the late 1950s, at the height of the postwar boom enjoyed by psychoanalysis in the United States, a fatidical observer commented shrewdly that, Despite pretentious affirmations to the contrary the fact is that psychoanalysis, on which modern psychiatry is largely based, is in a state of virtual collapse and imminent demise.1 Twenty years later the accuracy of his prediction was publicly underwritten by a cover story in Time magazine, pointedly entitled Psychiatry on the couch.2 In efficient, plastic prose psychiatry is presented in the role of patient, with the following clinical formulation :
Linear and non-linear properties of heart rate in postnatal maturation
Authors: R. Mrowka, A. Patzak, E. Schubert, P. B. Persson
Journal: Cardiovascular Research (1996)

An investigation was made of how postnatal maturation of cardiac control can be described by linear and non-linear methods of time series analysis.Sixteen healthy and term newborns were studied during their first 6 months of life. Power spectrum analysis including total power (TP), low frequency power (LF), high frequency power (HF) and LF/HF ratio were performed on the instantaneous heart rate (IHR) time series and mean heart rate (HR) was derived. The largest Lyapunov exponent (LLE) was calculated using a modified Wolf algorithm and checked by means of the surrogate-data test.There is an age dependency for the parameters LLE, HR, TP, HF, LF, LF/HF for active and LLE, HR, TP, HF, LF/HF for quiet sleep. HR is characterised by a steep increase between the 5th and 7th day. HF demonstrates a distinct development with high values around the first week and 90-180th day and low values around the 10-60th day. TP, LF and LF/HF show significantly higher values in active sleep in comparison to quiet sleep. For all ages and sleep stages, positive LLE were found, indicating sensitivity to initial conditions, a hall-mark of chaos. For the period between the 7 and 90th days of life, the LLE for active sleep took on larger values compared with the LLE of quiet sleep.This study shows that by linear as well as non-linear analysis one can reveal the complexity of the IHR development in humans and may gain insight into the system controlling the heart during the period considered. The positive LLE indicate that there is a non-linear component in the heart rate control. There is no "straight line" development for the parameters analysed within the first 6 months. This may result from manifold influences on the autonomic system, due to structural and functional maturation in this period of life.
Neovascularisation and the induction of cell adhesion molecules in response to degradation products from orthopaedic implants.
Authors: N al-Saffar, J.T. Mah, Y Kadoya, P.A. Revell
Journal: Annals of the Rheumatic Diseases (1995)

To characterise the cellular interactions and the mechanisms involved in the recruitment of inflammatory macrophages and T cells to the bone implant interface in 30 patients with aseptically loosened orthopaedic prostheses. Cell adhesion molecules E-selectin, VCAM-1, ICAM-1 and the receptors LFA-1 and CR3 were immunolocalised on cryostat sections of the bone-implant interface obtained during revision arthroplasty. The percentage of expression on vascular endothelium was determined on serial sections. E-selectin was upregulated on different vessels in 21 patients. Its expression correlated strongly with the presence of metal wear debris. VCAM-1 was detected on vessels in six patients only, and was coexpressed with E-selectin in three patients with metal debris. VCAM-1 was more frequently observed in the lining cells on the implant side. ICAM-1 was upregulated on vessels on the bone side only in 13 patients, and was more strongly expressed on aggregates of macrophages and multinucleated giant cells on the implant side. These macrophage aggregates coexpressed both ICAM-1 and CR3. Our findings implicate the contribution of three different pathways in the recruitment of inflammatory cells to the joint in response to orthopaedic implant wear particles. The association of E-selectin expression and metal debris may suggest hypersensitivity reactions. Finally, the simultaneous expression of ICAM-1 and CR3 on the same macrophages on the implant side may predict an additional function of these molecules in homotypic adhesion/cell aggregation that precede differentiation of phagocytes to multinucleated giant cells.
Study of fibrinolytic parameters in different types of polycythemia
Authors: G. Lugassy, I. Filin
Journal: American Journal of Hematology (1999)

Polycythemia vera (PV) is a myeloproliferative disorder characterized by thrombotic and, less often, bleeding complications. Many mechanisms have been advanced to explain the occurrence of these complications, none of them satisfactory. We examined a cohort of 27 patients with PV, secondary erythrocytosis, and essential thrombocythemia for coagulation and fibrinolytic parameters, including euglobulin lysis test, D-dimer, and alpha2 antiplasmin. Ten of the 27 patients developed one or more thrombotic complications during the study. We found no clinical correlation between the studied parameters and the complications. Three patients, one of each group, with elevated serum alpha2 antiplasmin levels, developed severe arterial or venous thromboses.
82. Cftr Gene Targeting in Murine ES Cells Mediated by the SFHR Technique
Authors: Federica Sangiuolo, Maria Favia, Lorenzo Guerra, Antonio Filareto, Maria Lucia Scaldaferri, Rosa Caroppo, Paola Spitalieri, Ruggiero Mango, Emanuela Bruscia, Dieter Gruenert, Valeria Casavola, Massimo De Felici, Giuseppe Novelli
Journal: Molecular Therapy (2006)

C57BL/6 and Balb/c mice were treated with (VSV)LV by intravenous injection.The content of viral RNA and vector provirus within the liver and spleen was monitored by real-time PCR.By 4 hours post-injection the majority of vector uptake and reverse transcription had occurred.RNase Protection Assay revealed that concomitant to vector entry there was a >10-fold induction of type I interferons (IFNs), TNFα, and the chemokine MIG in both the liver and spleen.This response was not due to contaminants in the vector preparation, as heat-inactivated and bald (envelope negative) LV particles did not result in innate activation.Cytokine expression following LV delivery was transient and largely subsided within 72 hours.However, clearance of vector genomes had already begun to occur by 24 hours.This effect may have been due to the antiviral activity of the IFNs, a possibility we will validate in IFN receptor knock-out mice.We next set out to determine the factors involved in mediating the response to LV. Initially we sought to identify if particular DC subsets were involved.Indeed, in vitro studies revealed that plasmacytoid, but not myeloid DCs became activated to produce IFNs following exposure to LV.Similar findings were also seen with human DCs.Moreover, experiments with the bald LV suggested that endosome uptake was required to induce the cytokine response.Taken together, these results suggest a role for toll-like receptor (TLR)-7, a TLR that recognizes ssRNA and is found predominantly within the endosomes of plasmacytoid DCs, in LV-mediated innate immune activation.Studies are now underway to determine whether antagonists of TLR-7 can prevent the innate response to LV, and enable stable gene transfer in the absence of adaptive immunity.
HIGH-SENSITVITY CARDIAC TROPONINS, COPEPTIN AND HEART-TYPE FATTY ACID-BINDING PROTEIN IN A SINGLE SAMPLE MULTI-MARKER APPROACH AT ADMISSION FOR THE DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION
Authors: Mikkel M. Schoos, Martin L. Nielsen, Jøgen Thode, Steen I. Hansen, Kasper Iversen, Peter Clemmensen, Rolf Steffensen
Journal: Journal of the American College of Cardiology (2013)
P669 A GENOME-WIDE ASSOCIATION STUDY ON PERSISTENT HBV INFECTION AND ITS CLINICAL SIGNIFICANCE IN MALE HAN-TAIWANESE
Authors: S.-W. Chang, C.S.-J. Fann, W.-H. Su, Y.C. Wang, C.C. Weng, C.-J. Yu, C.-L. Hsu, A.-R. Hsieh, R.-N. Chien, C.-M. Chu, D.-I. Tai
Journal: Journal of Hepatology (2014)