tbuckley/cabot-search huggingface dataset:
Clinical Course of Deep Venous Thrombosis
Authors: Richard H. White
Journal: Annals of Internal Medicine (1997)

Letters1 May 1997Clinical Course of Deep Venous ThrombosisRichard H. White, MD and Patrick S. Romano, MD, MPHRichard H. White, MDUniversity of California, Davis, Sacramento, CA 95817Search for more papers by this author and Patrick S. Romano, MD, MPHUniversity of California, Davis, Sacramento, CA 95817Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-9-199705010-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest the recent article by Prandoni and colleagues [1], which described the incidence of recurrent deep venous thrombosis after a first-time episode of thrombosis. The authors' data could be analyzed to answer a very important clinical question: Is the rate of recurrent deep venous thrombosis in younger patients (<55 years of age) with idiopathic deep venous thrombosis (that is, not following temporary exposure to a risk factor such as surgery, trauma, pregnancy, or significant immobilization) and no known procoagulant condition the same as that in younger persons with idiopathic deep venous thrombosis who have ...References1. Prandoni P, Lensing AW, Cogo A, Cuppini S, Villalta S, Carta M, et al. The long-term clinical course of acute deep venous thrombosis. Ann Intern Med. 1996; 125:1-7. Google Scholar2. Vandenbroucke JP, Koster T, Briet E, Reitsma PH, Bertina RM, Rosendaal FR. Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden. Lancet. 1994; 344:1453-7. Google Scholar3. Schulman S, Rhedin AS, Lindmarker P, Carlsson A, Larfars G, Nicol P, et al. A comparison of six weeks with six months of oral anticoagulant therapy after a first episode of venous thromboembolism. Duration of Anticoagulation Trial Study Group. N Engl J Med. 1995; 332:1661-5. Google Scholar Author, Article, and Disclosure InformationAuthors: Richard H. White, MD; Patrick S. Romano, MD, MPHAffiliations: University of California, Davis, Sacramento, CA 95817 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1997Volume 126, Issue 9Page: 743KeywordsDeep vein thrombosisFactor analysisFactor V LeidenHeparinMedical risk factorsOral contraceptive therapyPregnancyProtein C deficiencyProtein S deficiencyTrauma surgery ePublished: 15 August 2000 Issue Published: 1 May 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Recurrence of Bile Salt Export Pump Deficiency after Liver Transplantation
Authors: Paloma Jara, Loreto Hierro, Pilar Martínez-Fernández, Rita Alvarez-Doforno, Francisca Yánez, María C. Diaz, Carmen Camarena, Angela De la Vega, Esteban Frauca, Gema Muñoz-Bartolo, Manuel López-Santamaría, Javier Larrauri, Luis Alvarez
Journal: New England Journal of Medicine (2009)

Severe bile salt export pump (BSEP) deficiency is a hereditary cholestatic condition that starts in infancy and leads to end-stage liver disease. Three children who underwent orthotopic liver transplantation for severe BSEP deficiency had post-transplantation episodes of cholestatic dysfunction that mimicked the original disease. Remission of all episodes was achieved by intensifying the immunosuppressive regimen. The phenotypic recurrence of the disease correlated with the presence of circulating high-titer antibodies against BSEP that inhibit transport by BSEP in vitro. When administered to rats, these antibodies targeted the bile canaliculi and impaired bile acid secretion.
Bullous pemphigoid associated with internal malignancies: identification of 180-kDa antigen by Western immunoblotting
Authors: T. MURAMATSU, T. IIDA, H. TADA, M. HATOKO, N. KOBAYASHI, T. KO, T. SHIRAI
Journal: British Journal of Dermatology (1996)

We report three cases of bullous pemphigoid associated with internal malignancies. Two cases were associated with gastric cancer and one with rectal cancer. Immunoblot analysis, using epidermal extract of normal human skin, revealed that these patients' sera reacted only with bullous pemphigoid antigen with a molecular weight of 180 kDa (BP180). The relationship of BP180 to malignant tumours is discussed.
TRAINING OF THE SANITARY INSPECTOR
Authors: J. R. Roberts
Journal: BMJ (1930)

CT I81 I9301 I I~~~~~~~~~~~~~~~~~~~~~~~~~~~~~t KDI extenlt.lThle subje(ts of illminullologv aind, serology are presented by a series of practical stuldlies and(I in classes where the student is himself responsible both for a theoretical discuission and folr a' workinig demenonistration.Parasitology is of relativelv miniiior importance in Canada.A laboratory course-of 30 lhours is offered.A labora- tory course in p)ublic healtlh chemistry of 60 hours is designed to familiarize the student wl-ith the chemical methods for the examination of mnilk, water, and sewage, ailld the principles of water piurification and sewage treat- lent.XLecture aiid laborator y courses in epidemiology anI,ld -ital statistics comipr ise 220 hiours; lectures and -demonistrations in phy-siological anid industrial hygiene, 65 hours.The time allotted for field work, inicludinig attenldauce at clinics, is 250 hours; sa,nitation, 30 hours; history of preventiv-e medicine, 10 hours; puiblic health administration and nutrition and dietetics, 42 and 30 hours respectively.
Length variation and secondary structure of introns in the Mlc1 gene in six species of Drosophila
Authors: A. G. Clark, B. G. Leicht, S. V. Muse
Journal: Molecular Biology and Evolution (1996)

A nearly universal feature of intron sequences is that even closely related species exhibit a large number of insertion/deletion differences. The goal of the analysis described here is to test whether the observed pattern of insertion/deletion events in the genealogy of the myosin alkali light chain (Mlc1) gene is consistent with neutrality, and if not, to determine the underlying forces of evolutionary change. Mlc1 pre-mRNA is alternatively spliced, and one constraint is that signals necessary for tissue-specificity of directed splicing must be conserved. If the total length of an intron is functionally constrained, then the distribution of indels on branches of the gene genealogy should reflect a departure from randomness. Here we perform a phylogenetic analysis, inferring ancestral states wherever possible on a phylogeny of 29 alleles of Mlc1 from six species of Drosophila. Observed patterns of indels on the genealogy were compared to those from simulated data, with the result that we cannot reject the null hypothesis of neutrality. A clear departure from a neutral prediction was seen in the excess folding free energy predicted for the introns flanking the alternatively spliced exon. Relative rate tests also suggest a retardation in the rate of Mlc1 sequence evolution in the simulans clade.
Bird Flu Expands Range
Authors: Joan Stephenson
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
C Reactive protein and its relation to cardiovascular risk factors: a population based cross sectional study
Authors: M A Mendall, P. Patel, L. Ballam, D Strachan, T C Northfield
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objective</b>: To test the hypothesis that minor chronic insults such as smoking, chronic bronchitis, and two persistent bacterial infections may be associated with increases in C reactive protein concentration within the normal range and that variations in the C reactive protein concentration in turn may be associated with levels of cardiovascular risk factors and chronic coronary heart disease. <b>Design</b>: Population based cross sectional study. <b>Setting</b>: General practices in Merton, Sutton, and Wandsworth. <b>Subjects</b>: A random sample of 388 men aged 50-69 years from general practice registers. 612 men were invited to attend and 413 attended, of whom 25 non-white men were excluded. The first 303 of the remaining 388 men had full risk factor profiles determined. <b>Interventions</b>: Measurements of serum C reactive protein concentrations by in house enzyme linked immunosorbent assay (ELISA); other determinations by standard methods. Coronary heart disease was sought by the Rose angina questionnaire and Minnesota coded electrocardiograms. <b>Main outcome measures</b>: Serum C reactive protein concentrations, cardiovascular risk factor levels, and the presence of coronary heart disease. <b>Results</b>: Increasing age, smoking, symptoms of chronic bronchitis, Helicobacter pylori and Chlamydia pneumoniae infections, and body mass index were all associated with raised concentrations of C reactive protein. C Reactive protein concentration was associated with raised serum fibrinogen, sialic acid, total cholesterol, triglyceride, glucose, and apolipoprotein B values. C Reactive protein concentration was negatively associated with high density lipoprotein cholesterol concentration. There was a weaker positive relation with low density lipoprotein cholesterol concentration and no relation with apolipoprotein A I value. C Reactive protein concentration was also strongly associated with coronary heart disease. <b>Conclusion</b>: The body9s response to inflammation may play an important part in influencing the progression of atherosclerosis. The association of C reactive protein concentration with coronary heart disease needs testing in prospective studies. <h3>Key messages</h3> Factors that determine levels of inflammatory mediators in the normal general population have not been explored, nor has their relation to cardio- vascular risk factors Among 50-69 year old men many environmental and lifestyle risk factors for cardiovascular disease are associated with raised serum concentrations of C reactive protein Circulating concentrations of lipids, glucose, and clotting factors are also associated with serum C reactive protein concentrations The body9s response to inflammation may influence the development of atherosclerosis
The effects of processing methods upon mechanical and biologic properties of porcine dermal extracellular matrix scaffolds
Authors: Janet E. Reing, Bryan N. Brown, Kerry A. Daly, John M. Freund, Thomas W. Gilbert, Susan X. Hsiong, Alexander Huber, Karen E. Kullas, Stephen Tottey, Matthew T. Wolf, Stephen F. Badylak
Journal: Biomaterials (2010)
Penicillamine in the Treatment of Patients With Cystinuria
Authors: William B. MacDonald
Journal: JAMA (1966)

Contrary to the usual statements that cystinuria is a medical curiosity and a benign disease, observations of 16 individuals, including seven children, have shown that the consequences of cystine stone formation are of such serious nature as to markedly shorten life expectancy and induce both physical and mental anguish in involved persons. Thus, therapy directed toward the removal of the offending urinary cystine is warranted. This study shows the unequivocal value of penicillamine administered orally to patients with cystinuria; penicillamine will lower urinary cystine to levels which have not allowed further stone development in the treated individuals during the trial observation period. Further, early side effects have been surmounted, and no late effects have been noted up to one year of treatment. Suggested dosage of penicillamine is 30 mg/kg of body weight per day.
Pretzels and Fruitcake
Authors: Kathryn Rensenbrink
Journal: Annals of Internal Medicine (2000)

On Being a Doctor4 July 2000Pretzels and FruitcakeKathryn Rensenbrink, MDKathryn Rensenbrink, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-1-200007040-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail It is a peculiar privilege of a rural doctor to walk among one's dead. When I was training in San Francisco, I never considered the cemeteries. I was too busy analyzing test results and treatment options to wonder what happened when my patients went home, or when they died.In the rural Maine town where I now practice, my patients are also my neighbors. I find myself discussing inhalers in the bakery and clarifying diuretics in line at the supermarket. “Yes, Mr. Randolph, the one that makes you pee.” My patients see me in dirty sweats at the Y, they ... Author, Article, and Disclosure InformationAffiliations: Corresponding Author: Kathryn Rensenbrink, MD, Ellsworth Internal Medicine, 50 Union Street, Ellsworth, ME 04605. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 4 July 2000Volume 133, Issue 1Page: 71KeywordsEmotionsGamesHeartIntelligenceMouthRenal failureSafetyStrokeSweatTea Issue Published: 4 July 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
False-Positive Radionuclide Venography Caused by Distended Urinary Bladder
Authors: L LaROY, A ALI, P DONG, C PARK, E W FORDHAM, R McKENNA
Journal: Clinical Nuclear Medicine (1990)

A 60-year-old man with a history of prostatic carcinoma presented with left lower extremity swelling. A massively distended urinary bladder produced a false-positive radionuclide venogram.
Familial Hyperparathyroidism
Authors: STEPHEN J. MARX
Journal: Annals of Internal Medicine (1973)

Nine members of a kindred were hypercalcemic. The hypercalcemia was mild in all. A diagnosis of hyperparathyroidism in many could not be definitely established by standard methods, but measurement of parathyroid hormone levels in samples obtained by selective venous catheterization confirmed the presence of overactive parathyroid tissue. Venous catheterization indicated bilateral parathyroid disease in four of five previously unexplored patients. Three of the hypercalcemic individuals had additional manifestations of multiple endocrine adenomatosis. There were no known cases of peptic disease in the entire kindred, and both basal and stimulated gastrin levels showed no abnormalities.
Vertical Transmission of Hepatitis B Antigen in Taiwan
Authors: Cladd E. Stevens, R. Palmer Beasley, Julia Tsui, Wy-Chan Lee
Journal: New England Journal of Medicine (1975)

To determine the frequency of vertical transmission of hepatitis B antigen (HB5 Ag) from asymptomatic carrier mothers in Taiwan to their offspring, HB5 Ag was sought by radioimmunoassay and complement fixation. Of 158 babies born to carrier mothers, antigenemia developed in 63; 51 of these antigenemic babies had become antigen positive within the six months of life. Three inter-related factors were found to increase the risk that antigenemia would develop in the infant: a high maternal complement-fixation titer for HB5 Ag: presence of HB5 Ag in the baby's umbilical-cord blood: and antigenemia in siblings. In contrast to previous studies, these findings indicate that vertical transmission from carrier mothers frequently occurs, at least in Taiwan, and may partially explain Taiwan's high prevalence of HB5 Ag.
Vertebral rim lesions in the dorsolumbar spine.
Authors: R C Hilton, J Ball
Journal: Annals of the Rheumatic Diseases (1984)

The frequency, distribution, and histological characteristics of vertebral rim lesions have been studied at D11 and L4 in 117 post-mortem spines in subjects aged 13-96 years. Only one lesion was found in patients less than 30 years, but thereafter the frequency increased with age. At least one rim was affected in the majority of patients greater than or equal to 50 years. They were found more frequently in the upper than the lower rim and they were also more common anteriorly than posteriorly. Lesions were associated with focal avulsion of the annulus in an otherwise healthy disc or with annular tears running into the rim. Rim lesions can be recognised radiographically by the presence of the vacuum phenomenon, vertebral rim sclerosis with or without a cup-shaped defect in the rim and osteophytes confined to one side of the disc. The histological appearances suggest a traumatic aetiology, and since bone is known to be supplied with pain sensitive nerve endings the lesions may be important in the general context of low back pain.
Effects of methanol extract of chansu on hypothalamic-pituitary-testis function in rats
Authors: Shyi-Wu Wang, Ho Lin, Shiow-Chwen Tsai, Chii-Min Hwu, Yu-Chung Chiao, Chien-Chen Lu, Jiann-Jong Chen, Guei-Jane Wang, Cheng-Jen Chou, Lie-Chwen Lin, Chieh-Fu Chen, Paulus S. Wong
Journal: Metabolism (1998)
American Diabetes Association issues new guidelines for type 1 diabetes
Authors: M. McCarthy
Journal: BMJ (2014)

The American Diabetes Association has issued a new position statement providing guidance for the management of type 1 diabetes throughout a patient’s life.1

The statement was released and published online on 17 June during the association’s 2014 Scientific Sessions meeting, held this year in San Francisco, California.

For many patients, the target glycated hemoglobin A1c level should be less than 7%, the statement said. “Lowering A1c to below or around 7% has been shown to reduce microvascular complications of diabetes, and, if achieved soon after the diagnosis of diabetes, is associated with long term reduction in macrovascular disease. Therefore, a reasonable A1c goal for many nonpregnant adults with type 1 diabetes is <7%,” it said.

However, it …
High Court judge overturns GMC ruling on fitness to practise
Authors: C. Dyer
Journal: BMJ (2009)

A consultant surgeon has won a challenge in the High Court to a “flawed” decision that his fitness to practise was impaired, in a case that raises several questions about the General Medical Council’s procedures.

In 2007 a GMC panel imposed a 10 month suspension on Timothy Cheatle, a consultant general and vascular surgeon, over his treatment of an elderly patient, Mildred Swain, who had diabetes and vascular disease.

He performed a femoropopliteal bypass graft at Oldchurch Hospital in Essex in April 2002 to bypass a blocked artery in her thigh. The graft became infected, and the joint between the graft and the artery leaked. By the time she was readmitted and taken to the operating theatre it was too late to save her.

The panel found that Mr Cheatle failed to obtain and record informed consent, to take sufficient notice of signs of postoperative infection, and …
Incorrect Values in Table 4 of the Article by Kuller et al (Arthritis Rheumatol, March 2014)
Authors: Lewis H. Kuller, Rachel H. Mackey, Brian T. Walitt, Kevin D. Deane, V. Michael Holers, William H. Robinson, Jeremy Sokolove, Yuefang Chang, Simin Liu, Christine G. Parks, Nicole C. Wright, Larry W. Moreland
Journal: Arthritis & Rheumatology (2014)

In the article by Kuller et al in the March 2014 issue of Arthritis & Rheumatology (pages 497–507), there were several typographical errors in Table 4, column 5 (age-adjusted death rates per 1,000 person-years in the group of anti-CCP-negative patients with DMARD use at baseline). The corrected values for age-adjusted death rates (with 95% confidence intervals in parentheses) are as follows: general health excellent/very good 10.2 (3.2–33.6), general health good 16.7 (9.2–32.6), general health fair/poor 29.8 (14.2–62.8); no diabetes 16.8 (10.4–27.4), diabetes 27.5 (8.6–92.0); no CHD at baseline 16.7 (10.3-27.3), CHD at baseline 26.1 (10.2–71.6); physical function score on the SF-36 ≤85 17.9 (11.2–29.3), physical function score on the SF-36 >85 13.5 (3.6–56.6); waist circumference ≤88 cm 15.5 (8.0–30.3), waist circumference >88 cm 19.8 (11.1–37.7); total METs per week <2.5 20.0 (10.9–36.6), total METs per week 2.5–18.24 16.9 (9.0–32.1), total METs per week ≥18.25 18.2 (6.7–50.6); no hypertension 18.2 (10.3–32.5), hypertension 17.5 (8.8–36.4). Additionally, there were some typographical errors in Table 4, column 4 (weighted total in the group of anti-CCP–negative patients with DMARD use at baseline). The corrected values are as follows: general health excellent/very good 64, general health good 125, general health fair/poor 55. Finally, there was a typographical error in Table 1, column 3: the correct 95% confidence interval for the age-adjusted death rate in the group of anti-CCP-positive patients with no diabetes was 14.0–22.7. We regret the errors.
THE DEVELOPMENT OF A TOXEMIC CONDITION IN THE DOG DURING GESTATION
Authors: WILLIAM deB MacNIDER
Journal: JAMA (1928)

If information is sought from the textbooks on obstetrics and from many of the papers that deal with the pregnancy toxemias, the outcome is not infrequently an elaborate classification of these states which ranges all the way from a toxic psychosis to acute yellow atrophy of the liver. Such classifications may be necessary in order to clarify superficially a group of conditions the cause of which is unknown but which manifest themselves clinically by a wide variety of symptoms. Few attempts have been made through systematic study to determine whether there does not exist during gestation some generalized disturbance in the pregnant organism which may manifest itself through different organs and be in part responsible for changes in these tissues. Among these few and quite different from the usual type of investigation of these toxemias are the splendid studies of Stander and his associates,<sup>1</sup>Loeser<sup>2</sup>and Bakelmann.<sup>3</sup>