tbuckley/cabot-search huggingface dataset:
Lovastatin Sensitizes Lung Cancer Cells to Ionizing Radiation: Modulation of Molecular Pathways of Radioresistance and Tumor Suppression
Authors: Toran Sanli, Caiqiong Liu, Ayesha Rashid, Sarah N. Hopmans, Evangelia Tsiani, Carrie Schultz, Thomas Farrell, Gurmit Singh, James Wright, Theodoros Tsakiridis
Journal: Journal of Thoracic Oncology (2011)
More US citizens lack health insurance
Authors: Janice Tanne
Journal: BMJ (2006)

The number of US citizens without health insurance reached a record 46.6 million this year—an increase of 1.3 million on last year. This is according to the latest US Census Bureau's survey (www.census.gov/cps).

Almost one in six US residents lacks health insurance. The number of uninsured people has increased by seven million since 2000.

Nearly all the new people without insurance were working adults aged 18 to 64, who might previously have had employer based insurance cover. …
Response to flecainide infusion predicts long-term success of hybrid pharmacologic and ablation therapy in patients with atrial fibrillation
Authors: Giuseppe Stabile, Antonio De Simone, Pietro Turco, Vincenzo La Rocca, Pasquale Nocerino, Costantino Astarita, Francesco Maresca, Carmine De Matteis, Tommaso Di Napoli, Eugenio Stabile, Dino Franco Vitale
Journal: Journal of the American College of Cardiology (2001)
ON THE IMMEDIATE EFFECTS OF THE INHALATION OF CHLORINE GAS
Authors: E. Schafer
Journal: BMJ (1915)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following ON THE IMMEDIATE EFFECTS OF THE INHALATION OF CHLORINE GAS Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Increased Serum Concentrations of Procollagen Peptides in Essential Hypertension
Authors: Javier Díez, Concepción Laviades, Gaspar Mayor, María Jesús Gil, Ignacio Monreal
Journal: Circulation (1995)

The serum concentrations of two procollagen-derived peptides, procollagen type III amino terminal peptide (PIIIP) and procollagen type I carboxy terminal peptide (PIP), have been proposed as useful markers of the tissue synthesis of collagen type III and type I, respectively. Therefore, this study was designed to evaluate fibrogenic activity in patients with essential hypertension by measuring serum PIIIP and PIP. Furthermore, since hypertensive heart disease is characterized by myocardial accumulation of collagen type III and type I, a second aim of the study was to assess whether some relation exists between the serum concentrations of PIIIP and PIP and several parameters of left ventricular anatomy and function in hypertensive patients.The study was performed in 50 patients with never-treated essential hypertension and in 30 normotensive control subjects. Measurements were repeated in 43 hypertensive patients after 6 months of treatment with the angiotensin-converting enzyme inhibitor lisinopril. The serum concentrations of PIIIP and PIP were measured by specific radioimmunoassay. Two-dimensional, targeted M-mode and Doppler ultrasound recordings were obtained in every subject to determine several parameters of the left ventricle anatomy and function. Ambulatory ECG monitoring was performed in each patient, and the recorded ventricular arrhythmias were categorized according to Lown-Wolf classification. Baseline serum PIIIP and PIP were increased (P < .001) in hypertensive patients as compared with normotensive subjects. An inverse correlation was found between serum PIIIP and the ratio between maximal early transmitral flow velocity and maximal late transmitral flow velocity measured during diastole (r = .3786, P < .01) in the group of hypertensive patients. Serum PIP was correlated directly with the left ventricular mass index (r = .3277, P < .05) in the group of hypertensive patients. Serum PIP concentrations increased in parallel with the increase in the grade of ventricular arrhythmias in the group of hypertensive patients. Treated patients attained normalization in blood pressure, amelioration of diastolic filling, regression of left ventricular mass index, and a diminution in the number of daily ventricular extrasystoles. In addition, serum PIIIP and PIP concentrations decreased significantly (P < .001) to normal values in patients treated with lisinopril.These findings suggest that tissue synthesis of collagen type III and type I is abnormally increased in essential hypertension and can be normalized by treatment with lisinopril. On the other hand, our results suggest that serum PIIIP and PIP are related to several anatomic and functional alterations of the hypertensive left ventricle. Serum procollagen peptide measurements may therefore provide indirect diagnostic information on the myocardial fibrosis associated with arterial hypertension.
Positive and Negative CD4+ Thymocyte Selection by a Single MHC Class II/Peptide Ligand Affected by Its Expression Level in the Thymus
Authors: Yoshinori Fukui, Tatsuro Ishimoto, Masanori Utsuyama, Takahiro Gyotoku, Takahiro Koga, Kazutaka Nakao, Katsuiku Hirokawa, Motoya Katsuki, Takehiko Sasazuki
Journal: Immunity (1997)
Ethical Implications of Peer-Driven Recruitment: Guidelines from Public Health Research
Authors: Craig L. Fry
Journal: The American Journal of Bioethics (2010)

Click to increase image sizeClick to decrease image size C. Fry is supported by an NHMRC Australian Public Health Training Fellowship (519556), ARC Discovery Grant (1094144), the Murdoch Childrens Research Institute (Children's Bioethics Centre), and University of Melbourne (Centre for Applied Philosophy & Public Ethics).
The Gift: Hy’shqe Siam
Authors: William L Freeman
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bone Imaging as an Aid for the Diagnosis of Osteopoikilosis
Authors: EDDY C. K. TONG, MOHSEN SAMII, FELIX TCHANG
Journal: Clinical Nuclear Medicine (1988)

An unusual case of Osteopoikilosis was found in a 52-year-old black woman. The rather large diffuse focal increased densities involving the ribs, spine, and pelvis as seen in the roentgenograms were believed to represent metastatic bone lesions. The normal nuclide bone images helped revise the diagnosis to osteopoikilosis. Early recognition of osteopoikilosis would have prevented the patient's apprehension and the extensive work-up for the primary tumor.
What do we know about fundholding in general practice?
Authors: J. Dixon, H. Glennerster
Journal: BMJ (1995)

The general practice fundholding scheme was introduced four years ago. So far its impact has not been formally evaluated nationally, but review of published research shows some trends. Fundholding has curbed prescribing costs and given general practitioners greater power to lever improvements in hospital services--for example, reducing waiting times for hospital treatment--but fundholding practices may have received more money than non-fundholding practices. The impact of fundholding on transactions costs, equity, and quality of care (particularly for patients of non-fundholding general practitioners) is unknown. Research into costly reforms such as fundholding needs to be coordinated.
Selective Proximal Vagotomy with and without Pyloroplasty
Authors: C. Wastell, J. F. Colin, J. I. MacNaughton, J. Gleeson
Journal: BMJ (1972)

The early results of a prospective randomized clinical trial of selective proximal vagotomy with and without gastric drainage in a total of 36 patients are reported. In spite of adequate average acid reduction and little evidence of gastric retention two definite recurrent ulcers have occurred in the 16 patients who did not have a pyloroplasty. Further trials of the effect of selective proximal vagotomy without gastric drainage are necessary before the procedure is widely adopted.
International Geographic Variation in Event Rates in Trials of Heart Failure With Preserved and Reduced Ejection Fraction
Authors: Søren L. Kristensen, Lars Køber, Pardeep S. Jhund, Scott D. Solomon, John Kjekshus, Robert S. McKelvie, Michael R. Zile, Christopher B. Granger, John Wikstrand, Michel Komajda, Peter E. Carson, Marc A. Pfeffer, Karl Swedberg, Hans Wedel, Salim Yusuf, John J. V. McMurray
Journal: Circulation (2014)

International geographic differences in outcomes may exist for clinical trials of heart failure and reduced ejection fraction (HF-REF), but there are few data for those with preserved ejection fraction (HF-PEF).We analyzed outcomes by international geographic region in the Irbesartan in Heart Failure with Preserved systolic function trial (I-Preserve), the Candesartan in Heart failure Assessment of Reduction in Mortality and morbidity (CHARM)-Preserved trial, the CHARM-Alternative and CHARM-Added HF-REF trials, and the Controlled Rosuvastatin Multinational Trial in HF-REF (CORONA). Crude rates of heart failure hospitalization varied by geographic region, and more so for HF-PEF than for HF-REF. Rates in patients with HF-PEF were highest in the United States/Canada (HF hospitalization rate 7.6 per 100 patient-years in I-Preserve; 8.8 in CHARM-Preserved), intermediate in Western Europe (4.8/100 and 4.7/100), and lowest in Eastern Europe/Russia (3.3/100 and 2.8/100). The difference between the United States/Canada versus Eastern Europe/Russia persisted after adjustment for key prognostic variables: adjusted hazard ratios 1.34 (95% confidence interval, 1.01-1.74; P=0.04) in I-Preserve and 1.85 (95% confidence interval, 1.17-2.91; P=0.01) in CHARM-Preserved. In HF-REF, rates of HF hospitalization were slightly lower in Western Europe compared with other regions. For both HF-REF and HF-PEF, there were few regional differences in rates of all-cause or cardiovascular mortality.The differences in event rates observed suggest there is international geographic variation in 1 or more of the definition and diagnosis of HF-PEF, the risk profile of patients enrolled, and the threshold for hospitalization, which has implications for the conduct of future global trials.
[170] PREVALENCE OF HYPERDYNAMIC CIRCULATION AND PORTOPULMONARY HYPERTENSION IN PATIENTS UNDERGOING LIVER TRANSPLANT EVALUATION
Authors: A.M. Pellicelli, R. Villani, C. Struglia, L. Nauri, C. D'Ambrosio, L. Fondacaro, P. Guarascio, G. Barbara, A. Paffetti, M. Romano, A. Barlattani, F. Mecenate, E. Mazzoni, G. Barbarini, F. Soccorsi
Journal: Journal of Hepatology (2007)
Scintigraphic Demonstration of Viable Splenic Autotransplant
Authors: IVAN J. SZASZ, ALEXANDER NAGY
Journal: Clinical Nuclear Medicine (1986)

Over the past decade there has been increasing desire on the part of surgeons to preserve the spleen or splenic tissue following trauma to preserve the immunologic integrity of the body. This has led to a number of approaches to the treatment of splenic trauma, such as supportive therapy only, repair of tear, partial splenectomy, and autotransplantation of splenic tissue. The latter's benefit is disputed. A 15-year-old boy had several fragments of splenic tissue autotransplanted during splenectomy for a ruptured spleen. It was decided to follow him with Tc-99m sulphur colloid imaging after surgery to assess viability of the transplants. He had scintigraphic demonstration of viable splenic tissue, 3, 6, and 26 months following surgery.
Herpes Zoster in Small-Cell Carcinoma of the Lung
Authors: MAURIE MARKMAN
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 January 1982Herpes Zoster in Small-Cell Carcinoma of the LungMAURIE MARKMAN, M.D., MARTIN D. ABELOFF, M.D.MAURIE MARKMAN, M.D.Search for more papers by this author, MARTIN D. ABELOFF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-1-122_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The development of herpes zoster is a well-recongized complication of the treatment of Hodgkin's and non-Hodgkin's lymphomas (1). Recently, two groups of investigators have reported a 10% incidence of zoster in patients with small-cell carcinoma of the lung treated with combination chemotherapy, radiotherapy, or both (2, 3).For the past several years, we have treated patients with small-cell carcinoma of the lung with intensive combination chemotherapy with and without radiotherapy (4). The medical records of 92 patients treated on several protocols using multiple chemotherapeutic agents (including high-dose cyclophosphamide) were reviewed to ascertain whether our experience supported the...References1. SCHIMPFF S, SERPICK A, and STOLER B. Varicella-zoster infection in patients with cancer. Ann Intern Med. 1972;76:241-54. LinkGoogle Scholar2. FELD R, EVANS W, and DEBOER G. Herpes zoster in patients with small cell carcinoma of the lung receiving combined modality treatment. Ann Intern Med. 1980;93:282-3. LinkGoogle Scholar3. HUBERMAN M, FOSSIECK B, BUNN P, COHEN M, IHDE D, and MINNA J. Herpes zoster and small cell bronchogenic carcinoma. Am J Med. 1980;68:214-8. CrossrefMedlineGoogle Scholar4. ABELOFF M, ETTINGER D, and ORDER S. Intensive induction chemotherapy in 54 patients with small carcinoma of the lung. Cancer Treat Rep. 1981;65:639-46. MedlineGoogle Scholar5. MARKMAN M and ABELOFF M. No predisposition to herpes zoster with chemotherapy of breast cancer. N Engl J Med. 1981;304:789. Letter. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MAURIE MARKMAN, M.D.; MARTIN D. ABELOFF, M.D.Affiliations: The Johns Hopkins Oncology Center Baltimore, MD 21205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPredictors of 5-year survival and curability in small cell lung cancerManagement of hematologic and infectious complications of intensive induction therapy for small cell carcinoma of the lung 1 January 1982Volume 96, Issue 1Page: 122-123KeywordsChemotherapeutic agentsCombination chemotherapyCyclophosphamideLung and intrathoracic tumorsLymphomaRespiratory system procedures ePublished: 1 December 2008 Issue Published: 1 January 1982 PDF downloadLoading ...
Response of Resistant Idiopathic Thrombocytopenic Purpura to Pulsed High-Dose Dexamethasone Therapy
Authors: Judith C. Andersen
Journal: New England Journal of Medicine (1994)

Most patients with chronic idiopathic thrombocytopenic purpura have a response to corticosteroids or intravenous immune globulin, but improvement is often transitory. Splenectomy may provide only a short-term benefit. Because pulsed high-dose therapy with potent synthetic corticosteroids is inexpensive, well tolerated, and effective in patients with secretory B-cell neoplasms, a similar regimen was examined for its efficacy in patients with chronic idiopathic thrombocytopenic purpura that was resistant to other treatments.Ten consecutively referred patients who had persistent symptomatic idiopathic thrombocytopenic purpura after undergoing at least two standard therapies were treated with six cycles of dexamethasone (40 mg per day for 4 sequential days every 28 days).All patients had increased platelet counts (mean [+/- SD] count before treatment, 12,000 +/- 8200 per cubic millimeter; after treatment, 248,000 +/- 130,000 per cubic millimeter). The platelet counts remained above 100,000 per cubic millimeter for at least six months after the last cycle of treatment. There were no serious side effects. Features of hyperadrenocorticism due to prior corticosteroid therapy resolved during treatment. The cost of the drug was approximately $100 per patient.Although the possibility of spontaneous remission and a delayed benefit from prior therapy cannot be excluded in this small group of patients, pulsed high-dose treatment with dexamethasone may provide a low-cost therapeutic option with minimal side effects in patients with refractory idiopathic thrombocytopenic purpura.
Indian generics manufacturer Ranbaxy agrees to pay $500m to settle US fraud and drug safety charges
Authors: M. Kay
Journal: BMJ (2013)

Generic drug manufacturer Ranbaxy has agreed to pay a fine of $500m (£330m; €385m) to settle US government charges of fraud at two of its Indian factories, which came to light eight years ago. The fine is the largest ever in US history to be paid by a generic manufacturer over drug safety.

Ranbaxy USA, a subsidiary of Indian generic pharmaceutical manufacturer Ranbaxy Laboratories, will pay a criminal fine and forfeiture of $150m, plus $350m to settle civil claims brought by the federal government and all 50 US states.

US Food and …
Markers for faecal fat estimation in monitoring steatorrhoea in cystic fibrosis.
Authors: J Gilbert, J Kelleher, M P Walters, J M Littlewood
Journal: Gut (1988)

Polyethylene glycol (PEG) 4000 is one of numerous substances used as non-absorbable markers to correct for variable faecal output when assessing daily faecal losses of nutrients. The introduction of enteric coated micro-encapsulated pancreatic enzyme (EMPE) preparations has greatly improved the control of fat malabsorption in cystic fibrosis and chronic pancreatitis patients. Unfortunately, these enzyme preparations contain significant quantities of PEG 4000 or polyvinyl pyrrolidine (PVP) as components of the enteric coating and thus PEG 4000 cannot be used either as a faecal marker, or in intubation studies, if these enzyme preparations are being used.
Low molecular weight heparin in atrial fibrillation prior to cardioversion: Short-term safety and efficacy in a transesophageal echocardiography prospective study
Authors: Lydia Djaouti, Charles Smadja, Nadia Benyounes, Catherine Albo, Olivier Belliard, Franck Boccara, Ariel A. Cohen
Journal: Journal of the American College of Cardiology (2003)
Treatment of Chronic Immune Thrombocytopenic Purpura
Authors: Z. Steven Pavletic
Journal: Annals of Internal Medicine (1997)

Letters1 October 1997Treatment of Chronic Immune Thrombocytopenic PurpuraZ. Steven Pavletic, MDZ. Steven Pavletic, MDUniversity of Nebraska Medical Center; Omaha, NE 68198-3330Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-7-199710010-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:McMillan [1] thoroughly reviewed therapeutic alternatives for patients with refractory chronic immune thrombocytopenic purpura. Another clinical concept, based on animal models and circumstantial clinical evidence, is emerging. Increasing safety and cost-effectiveness of hematopoietic stem-cell transplantation in the area of malignant diseases extended the availability of such procedures to patients with severe autoimmune disorders, including immune thrombocytopenic purpura [2, 3]. Remissions in patients with this latter condition in whom multiple therapies had previously failed and who were treated with autologous or allogeneic stem-cell transplantation have already been reported [4, 5]. The hope is that more intensive immuno-suppression, in ...References1. McMillan R. Therapy for adults with refractory chronic immune thrombocytopenic purpura. Ann Intern Med. 1997; 126:307-14. Google Scholar2. Bennett C, Armitage J, Armitage G, Vose JM, Bierman PJ, Armitage JO, et al. Costs of care and outcomes for high-dose therapy and autologous transplantation for lymphoid malignancies: results from the University of Nebraska 1987 through 1991. J Clin Oncol. 1995; 13:969-73. Google Scholar3. Marmont A, Tyndall A, Gratwohl A, Vischer T. Hematopoietic precursor-cell transplants for autoimmune diseases. Lancet. 1995; 345:978. Google Scholar4. Lim SH, Kell J, Al-Sabah A, Mumar-Bashi W, Bailey-Wood R. Peripheral blood stem cell transplantation for severe refractory autoimmune thrombocytopenic purpura [Abstract]. Blood. 1996; 88(Suppl 1):133a. Google Scholar5. Raetz E, Beatty PG. Cord blood transplantation for refractory Evans syndrome [Abstract]. First International Meeting on Hematopoietic Stem Cell Therapy in Autoimmune Diseases. Basel, Switzerland. September 1996:18. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Nebraska Medical Center; Omaha, NE 68198-3330 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNovel Therapeutic Approaches in Autoimmune Skin DisordersNovel Therapeutic Approaches in Autoimmune Skin Disorders 1 October 1997Volume 127, Issue 7Page: 572KeywordsAnimal modelsAutoimmune diseasesIdiopathic thrombocytopenic purpuraImmune systemSafetyTransplantation Issue Published: 1 October 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effects of oral and inhaled salbutamol and oral pirbuterol on right and left ventricular function in chronic bronchitis.
Authors: R J Winter, J A Langford, R M Rudd
Journal: BMJ (1984)

In many patients with chronic bronchitis and emphysema right and left ventricular ejection fractions (RVEF and LVEF) are reduced. A study was conducted using multiple gated equilibrium radionuclide ventriculography to compare the effects of oral salbutamol 4 mg and pirbuterol 15 mg on cardiac function in 12 patients with chronic bronchitis (forced expiratory volume in one second 0.86 (SEM 0.12) 1; arterial oxygen pressure 8.2 (SEM 0.5) kPa (61.7 (SEM 3.8) mm Hg)). Different doses of nebulised salbutamol (500 microgram and 5 mg) were also compared in nine of the patients. Both oral salbutamol and oral pirbuterol produced significant increases in RVEF and LVEF at 60 and 90 minutes after drug ingestion (p less than 0.01 in each case). There were no significant differences between salbutamol and pirbuterol in their effects on RVEF and LVEF. Inhaled salbutamol at doses commonly prescribed had no significant effect on RVEF and LVEF after 20 and 60 minutes. Salbutamol and pirbuterol given by mouth have similar actions on RVEF and LVEF. Further studies are necessary to assess the effects of long term B2 agonists in this group of patients.