tbuckley/cabot-search huggingface dataset:
Increases in Allergen-Specific IgE in BAL after Segmental Allergen Challenge in Atopic Asthmatics
Authors: DUNCAN R. WILSON, TERRY G. MERRETT, EVA M. VARGA, LYN SMURTHWAITE, HANNAH J. GOULD, MICHAEL KEMP, JAMES HOOPER, STEPHEN J. TILL, STEPHEN R. DURHAM
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

IgE is important in both early and late allergic responses. Increases in the numbers of RNA transcripts coding for IgE have been observed in the bronchial mucosa of asthmatics and in the nasal mucosa of hay fever patients both during natural allergen exposure and after nasal allergen challenge, suggesting that IgE may be synthesized locally in the mucosa. In this study we have examined bronchoalveolar lavage (BAL) taken before and 24 h after bronchoscopic segmental allergen challenge from 18 atopic asthmatic patients, looking for evidence of increases in IgE protein. Allergen-specific IgG and total and allergen-specific IgE were measured in BAL using a fluoroenzyme immunoassay. There was a significant increase in allergen-specific IgE (Ku/L) in the BAL after allergen challenge {before [median (interquartile range)] 0 (0, 0); after 0.35 (0, 1.87): p = 0.009} which was not observed for allergen-specific IgG (p = 1.0) or for IgE specific to an allergen to which the subject was sensitized but was not used for provocation (p = 1.0). Correction for corresponding increases in total IgE, albumin, and urea in BAL did not affect the observed changes in allergen-specific IgE. These data indicate that allergen provocation results in a selective local accumulation of isotype-specific and allergen-specific IgE antibody within the bronchi, independent of alterations in circulating IgE.
PATIENTS' ATTITUDES AND BEHAVIOR IN WARD ROUND TEACHING
Authors: JOHN ROMANO
Journal: JAMA (1941)

Bedside teaching is an established procedure in medical education. Its value as a teaching method and the advantages and disadvantages to the instructor and student have been considered by others. The patients' reactions to this procedure, on the other hand, have received little attention. There have been numerous essays which have considered the patient-physician relationship and the need for interpretation of personality structure with expression of sympathy and tact at the bedside. However, these have not been based on direct study of patients' reactions and are, for the most part, points of view and appeals for sympathetic attitudes. In order to obtain more objective data, an investigation was undertaken to study patients' reactions and behavior during ward round teaching. Specific attempts were made to discover whether the experience is traumatic, to gain further insight into patients' reactions to their illnesses and to learn how the procedure might be utilized as
Top of the pile: the institutes.
Authors: R Smith
Journal: BMJ (1991)

Critical mass seems to be essential for internationally competitive research.But large research institutions may easily become bureaucratic, atherosclerotic, and unproductive.Another dilemma is that most researchers insist that scientists work best when free to do whatever research they want, but those funding research want value for money and answers to problems with clinical and social importance.Everywhere, those organising research efforts must battle with these dilemmas, and often they fail.The medical research institutes of Australia are organisations that seem well designed to find a middle way, and generally they are, I judge, succeeding.The institutes have their roots not, however, in any clever plan to solve semiphilosophical dilemmas but rather in a need to provide practical answers to pressing problems.They have mostly grown organically around productive scientists to establish high quality medical research in Australia and to attract back bright researchers from overseas.In the early days the institutes
Monoclonal cytolytic T-cell lines.
Authors: P E Baker, S Gillis, K A Smith
Journal: The Journal of Experimental Medicine (1979)

Monospecific cloned cytolytic T-lymphocyte lines have been created utilizing T-cell growth factor. The clones were found to retain their cytolytic specificity after prolonged culture and monospecific function was demonstrated by subcloning procedures. Thus, detailed studies of the phenotypic and functional characteristics of monospecific, homogeneous, cytolytic T lymphocytes will now be possible.
Immunonutrition in Critical Illness
Authors: Todd W. Rice
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CIRCULATING VEGF CONCENTRATIONS ARE INDEPENDENTLY PREDICTIVE OF CORONARY ARTERY DISEASE SEVERITY MEASURED BY QUANTITATIVE CORONARY ANGIOGRAPHY IN PATIENTS WITH STABLE ANGINA
Authors: Remi Kouz, Eric Rheaume, Colin Berry, Anne-Elen Kernaleguen, Geneviève Brand, Jean Grégoire, Reda Ibrahim, Jacques Lespérance, Philippe L'Allier, Stéphane Noble, Philippe Meyer, Marie-Claude Guertin, Jean-Claude Tardif
Journal: Journal of the American College of Cardiology (2011)
A Wet Mouse
Authors: Jack C. Redman
Journal: JAMA (1984)

It was summer in the Mekong Delta. Miles of rice paddies, crisscrossed by canals, lay under humid, motionless air. Midday temperatures were 110 degrees. I was in the provincial hospital in Bac Lieu, South Viet Nam, located 120 miles southwest of Saigon, on the southeastern coast of that war-torn country. Not far to the west lay the U Minh forest, sanctuary of the Viet Cong.  I had flown to Viet Nam the month before. I was one of a group of the American Medical Association's Volunteer Physicians for Viet Nam. Dr Meritt Stark, a Denver pediatrician, and I had been assigned to go to Bac Lieu, a city of 60,000 people. He was a pediatrician and I was a surgeon. We were to work with the Vietnamese chef du medicin Dr Nguyen Thu Vinh and the US Army doctors of the 51st Advisory Team. The only American troops in Bac
Identification of a Putative Microvascular Oxygen Sensor
Authors: David R. Harder, Jayashree Narayanan, Eric K. Birks, Jean Francois Liard, John D. Imig, Julian H. Lombard, Andrew R. Lange, Richard J. Roman
Journal: Circulation Research (1996)

The vascular response to changes in oxygen levels in the blood and tissue is a highly adaptive physiological response that functions to match tissue oxygen supply to metabolic demand. Defining the cellular mechanisms that can sense physiologically relevant changes in P o 2 and adjust vascular diameter are vital to our understanding of this process. A cytochrome P450 (P450) enzyme of the 4A family of ω-hydroxylases was localized in renal microvessels, renal cortex, and a striated muscle microvascular bed (cremaster) of the rat. In the presence of molecular oxygen, this P450 enzyme catalyzes formation of 20-HETE from arachidonic acid (AA). Prior studies have shown that 20-HETE potently contracts renal and cerebral arteries and arterioles. The present study demonstrates that 20-HETE constricts striated muscle arterioles as well. In both intact renal microvessels and enriched renal cortical microsomal enzyme preparations, the formation of 20-HETE was linearly dependent on P o 2 between 20 and 140 mm Hg. Homogenates of cremaster tissue produced 20-HETE when incubated with AA. They also expressed message for P450 4A enzyme, as determined by Southern and Western blots. Administration of 17-octadecynoic acid (17-ODYA), which is a P450 4A inhibitor, attenuated the constriction of third-order cremasteric arterioles in response to elevation of superfusion solution P o 2 from ≈3 to 5 mm Hg to ≈35 mm Hg. 17-ODYA had no effect on basal vascular tone or response of cremaster arterioles to vasoactive compounds. These results demonstrate the existence of P450 ω-hydroxylase activity and 20-HETE formation in the vasculature and parenchyma of at least two microvascular beds. Our data suggest that a P450 enzyme of the 4A family has the potential to function as an oxygen sensor in mammalian microcirculatory beds and to regulate arteriolar caliber by generating 20-HETE in an oxygen-dependent manner.
Diagnosis and Management of Infections Involving Implantable Electrophysiologic Cardiac Devices
Authors: Jimmy Dy Chua
Journal: Annals of Internal Medicine (2000)

Optimal treatment of infections related to implantable electrophysiologic cardiac devices is poorly defined.To describe the clinical presentation, treatment, and outcome of patients with such infections.Retrospective case series.The Cleveland Clinic Foundation, Cleveland, Ohio.123 patients with infections involving implantable cardiac electrophysiologic devices.Demographic characteristics, clinical manifestations, time to diagnosis, management, and outcome.87 patients with permanent pacemakers and 36 patients with implantable cardioverter defibrillators had infections. The most common signs and symptoms were pocket erythema and local pain. The most common pathogens were coagulase-negative staphylococci (68%) and Staphylococcus aureus (23%). In 117 patients (95%), all equipment was extracted and antibiotic therapy lasted a median of 28 days. Operative mortality was zero. Follow-up showed crude mortality and relapse rates of 8% and 3%, respectively.For infections related to implantable electrophysiologic devices, complete device removal and antimicrobial therapy allow timely, successful reimplantation at a remote anatomic site without substantial risk for operative mortality or recurrent infection.
An Epidemiological Assessment of Bundle-Branch Block
Authors: ROBERT E. EDMANDS
Journal: Circulation (1966)

Complete bundle-branch block was found in 57 of 1,560 (3.7%) electrocardiograms routinely recorded on members of a retirement community. Of this number, 19 were identified as left bundle-branch block (LBBB), while 38 fulfilled the criteria for right bundlebranch block (RBBB). Individuals with LBBB were found to have cardiomegaly more frequently than did individuals with normal electrocardiograms. Individuals with RBBB, regarded as a homogeneous group, also demonstrated a greater prevalence of cardiomegaly than did the control group, but the difference from normals was less striking than in the case of LBBB. Neither LBBB nor RBBB was significantly associated with hypertension, as defined in the text. When the common, uncomplicated RBBB was regarded as a separate entity, the prevalences of hypertension and cardiomegaly were indistinguishable from those of a control group with normal electrocardiograms. The RBBB variant, regarded as a possible manifestation of left ventricular disease secondary to hypertrophy or myocardial infarction, was found to be frequently associated with hypertension, cardiomegaly, and the need for digitalis therapy. RBBB with left axis deviation, regarded as a complication of the common RBBB due to left ventricular hypertrophy or myocardial infarction, was similarly associated with a high prevalence of cardiovascular disease. None of the 38 cases of RBBB fulfilled the criteria for classic RBBB. It is suggested, therefore, that the chronic uncomplicated RBBB in the adult may indeed bear a less ominous portent than has previously been ascribed to it. This is suggested only in relation to the parameters evaluated, however; prospective evaluation is clearly necessary to assess the validity of such an inference.
Activation/organization, masculinization/feminization: What are they and how are they distinguished?
Authors: Melissa Hines
Journal: Behavioral and Brain Sciences (1998)

The activational and organizational hormone effects as originally defined do not conflict with activational influences on brain structure. Ovarian hormonal influences on the rodent corpus callosum could be activational rather than organizational. The masculinization/feminization distinction in brain structure and the timing of sex differences in visuo-spatial abilities need to be clarified.
The FDA and Drug Uses: Reprise
Authors: Stuart L. Nightingale
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The recent editorial by Dr Archer<sup>1</sup>is a useful addition to the literature exploring the nature and significance of official Food and Drug Administration (FDA) drug labeling and the role of such information in drug selection and use by physicians. The editorial correctly notes that the FDA cannot approve or disapprove of how a physician uses lawfully marketed drugs. The FDA can and does, however, approve indications for a drug's use and approves what a drug manufacturer may say in labeling, advertising, or publications intended to acquaint physicians with a drug's properties and uses. Although FDA officials<sup>2,3</sup>have over the years sought to clarify the status and role of approved drug labeling, we felt that a wider audience needed to have an authoritative policy statement on this issue. We chose the<i>FDA Drug Bulletin</i>,<sup>4</sup>as Archer notes, as the most appropriate vehicle since it
Relative and Absolute Quantitation of Ten Allergens in Twenty Commercial Soybean Varieties Using Tandem Mass Spectrometry
Authors: N.L. Houston, D.G. Lee, S.E. Stevenson, G.S. Ladics, G.A. Bannon, S. McClain, L. Privalle, N. Stagg, C. Herouet-Guicheney, J.J. Thelen
Journal: Journal of Allergy and Clinical Immunology (2011)
Review of Marc A. Rodwin,<i>Conflicts of Interest and the Future of Medicine: The United States, France and Japan</i>
Authors: Stephen R. Latham
Journal: The American Journal of Bioethics (2011)

"Review of Marc A. Rodwin, Conflicts of Interest and the Future of Medicine: The United States, France and Japan ." The American Journal of Bioethics, 11(10), pp. 36–37
miR-122a-Regulated Expression of a Suicide Gene Prevents Hepatotoxicity Without Altering Antitumor Effects in Suicide Gene Therapy
Authors: Takayuki Suzuki, Fuminori Sakurai, Shin-Ichiro Nakamura, Emi Kouyama, Kenji Kawabata, Masuo Kondoh, Kiyohito Yagi, Hiroyuki Mizuguchi
Journal: Molecular Therapy (2008)

The combined use of adenovirus (Ad) vectors expressing herpes simplex virus thymidine kinase (HSVtk) and ganciclovir (GCV) offers a potential therapeutic strategy against cancer. However, intratumorally injected Ad vectors are disseminated into the systemic circulation and efficiently transduce the liver, resulting in severe hepatotoxicity. In order to overcome this problem, an Ad vector carrying a microRNA (miRNA)-regulated expression system was developed by inserting into the 3'-untranslated region (3'-UTR) of the expression cassette four tandem copies of sequences with perfect complementarity to miR-122a, which exhibits liver-specific expression. Transgene expression from the Ad vector carrying the miR-122a target sequences was 7- to 70-fold lower in cells with high miR-122a expression as compared to expression from a conventional Ad vector. Intratumoral injection of the Ad vector containing the miR-122a target sequences resulted in a 130- to 1,500-fold reduction in hepatic transgene products (without affecting the transgene expression in the tumor) when compared with those from a conventional Ad vector. In suicide gene therapy, the inclusion of the miR-122a target sequences in the HSVtk expression cassette achieved not only significant antitumor effects, but also a dramatic reduction in HSVtk/GCV-induced hepatotoxicity. These results indicate that Ad vectors that mediate miR-122a-regulated HSVtk expression provide a safe and efficient suicide gene therapy strategy.
Dequalinium and Balanitis
Authors: R. B. Coles, W. T. Simpson, D. S. Wilkinson
Journal: BMJ (1964)

complication which I find fairly frequently -namely, pain in the right subcostal area.I feel certain that it is a manifestation of change in the biliary system, but it is not a colic, the pain being dull and steady with tenderness in the same area.One patient had an area of paraesthesia in addition.It tends to continue intermittently throughout the prenatal course and disappears after delivery.To date I have found no good explanation for it, or method of relieving it, other than by using analgesics.-Iam, etc.,
Ring‐shaped nuclei in human neutrophilic leukocytes of healthy individuals: Evidence of their occurrence and characteristics
Authors: Humberto R. A. Cabral, Gabriela B. Robert
Journal: American Journal of Hematology (1989)

Abstract In our previous work we found the presence of ring‐shaped nuclei in circulating neutrophils of healthy individuals whose nuclei were stained only by means of the Feulgen reaction [1]. In our present work, we performed another study on the blood of 52 healthy human donors and stained their blood films with hematoxylin. In all cases, ring‐shaped nuclei were revealed. In this series, the number of this type of nuclei was high: 15.61% ± SD 7.18%. The ring nuclei of healthy humans had thin segments, such as we had previously found by means of Feulgen method.
Stress in Parents of Children With Diabetes Mellitus
Authors: Emily J Hauenstein, Robert S Marvin, Andrea L Snyder, William L Clarke
Journal: Diabetes Care (1989)

The level of stress experienced in the parenting role by mothers of 49 children with insulin-dependent diabetes mellitus (IDDM) and its relationshipto glycemic control was examined with the parenting stress index (PSI). A subsample of the research group of 25 children with diabetes (≤11 yr old) was compared with an agematched control group (n = 21) drawn from the original study of the PSI on total stress, parent- and childdomain, and subdomain scale scores. The two groups differed on one child-domain subscale, whereby children with diabetes are perceived by their mothers as more demanding than healthy controls. Three parentsubscale differences existed between the two groups, with mothers of children with diabetes reporting less attachment to their children, less spousal support, and poorer health. Analysis of the diabetes sample demonstrated significant stress on several of the child- and parent-domain subscales in a large proportion of the sample. Stress, at levels s≥70th percentile of the control group, existed on the child scales of acceptability, mood, demanding behavior, and reinforcement for 51% of children with diabetes. Elevations associated with stress in the parenting role were evident on the scales associated with parental attachment, depression, and competence for 33% of parents. No differences in the level of glycosylated hemoglobin (HbA1) existed between children whose mothers reported high levels of stress in themselves and their children and those whose mothers reported little stress. Hierarchal regression analysis demonstrated a significant relationship between the child stress scale of distractibility, the use of self-monitoring blood glucose.
COMPARISON OF A MINIMALIST APPROACH TRANSFEMORAL TAVR WITH STANDARD APPROACH TRANSFEMORAL TAVR IN A US CENTER
Authors: Vasilis C. Babaliaros, Chandan Devireddy, Stamatios Lerakis, Robert Leonardi, Sebastian Iturra, Kreton Mavromatis, Bradley Leshnower, Robert Guyton, Mihir Kanitkar, Patricia Keegan, Amy Simone, James Stewart, Iman Aziz, Nima Ghasemzadeh, Peter Block, Vinod Thourani
Journal: Journal of the American College of Cardiology (2014)
Levodopa for the Treatment of Parkinson's Disease
Authors: Peter A Lewitt
Journal: New England Journal of Medicine (2008)

A 62-year-old man presents with Parkinson's disease, and treatment with levodopa is recommended. Levodopa, a naturally occurring amino acid that is metabolized to dopamine in the brain, is considered the most effective drug available for Parkinson's disease. However, after several years of therapy, serious side effects, including motor fluctuations and dyskinesias, may occur.
Extensive Grover's-like eruption with lentiginous 'freckling': report of two cases
Authors: S.M. Cooper, J. Dhittavat, P. Millard, S. Burge
Journal: British Journal of Dermatology (2004)

We have described two females with extensive freckling and scaly lesions and conclude that they have a widespread form of Grover's disease associated with lentiginous sun‐induced ‘freckling’. We report these cases to draw attention to an unusual pattern of Grover's disease that can simulate Darier's disease.
Amelioration of Cardiac Morphology and Function in Type 1 Diabetic Patients With Sustained Success of Pancreas Transplant Alone
Authors: Margherita Occhipinti, Lorenzo Rondinini, Rita Mariotti, Fabio Vistoli, Walter Baronti, Massimiliano Barsotti, Gabriella Amorese, Ugo Boggi, Piero Marchetti
Journal: Diabetes Care (2014)

Pancreas transplant alone (PTA) is coming of age for the treatment of selected type 1 diabetic (T1D) patients (1). By restoring endogenous insulin secretion, it eliminates acute diabetes complications and may improve late microvascular complications (1,2). However, the impact of PTA on the recipient’s heart is largely unknown. Here, we report that successful PTA is associated with long-term amelioration of cardiac morphology and function.

As of December 2013, 93 PTAs have been performed in our center, with 5-year patient and pancreas survival of 97 and 76%, respectively (2). Indications and contraindications for PTA, surgery, and immunosuppression were as previously reported (1,2). From this cohort, 30 consecutive successfully transplanted patients (males 50%; age 38 ± 8 years; BMI 24.0 ± 2.8 kg/m2; diabetes duration 25 ± 9 years; insulin dose 47 ± …
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, a Carcinogen in High- Temperature-Cooked Meat, and Breast Cancer Risk
Authors: R. Sinha, D. R. Gustafson, M. Kulldorff, W.-Q. Wen, J. R. Cerhan, W. Zheng
Journal: JNCI Journal of the National Cancer Institute (2000)