tbuckley/cabot-search huggingface dataset:
Charles James Constantine Davey
Authors: G M Cooper, J Bullen
Journal: BMJ (2001)

Obstetrician and gynaecologist who worked with Fleming on the role of penicillin in treating venereal diseaseDuring the second world war Jack Suchet was initially retained at St Mary's, where he was not only registrar in the department of obstetrics but also became assistant and then director of the department of venereology.He became adviser in venereology to the war office and because of this appointment he worked closely with Sir Alexander Fleming on the role of penicillin in the revolutionary
Ventricular arrhythmias following autologous skeletal myoblast implantation
Authors: Warren Sherman, Kun-Lun He, Geng-Hua Yi, Hua Zhou, Angou Gu, Eva M. Becker, Ge-Ping Zhang, Jack Harvey, Race Kao, Myung J. Lee, Jie Wang, Howard Haimes, Daniel Burkhoff
Journal: Journal of the American College of Cardiology (2003)
Functional assembly of intrinsic coagulation proteases on monocytes and platelets. Comparison between cofactor activities induced by thrombin and factor Xa.
Authors: M P McGee, L C Li, M Hensler
Journal: The Journal of Experimental Medicine (1992)

Generation of coagulation factor Xa by the intrinsic pathway protease complex is essential for normal activation of the coagulation cascade in vivo. Monocytes and platelets provide membrane sites for assembly of components of this protease complex, factors IXa and VIII. Under biologically relevant conditions, expression of functional activity by this complex is associated with activation of factor VIII to VIIIa. In the present studies, autocatalytic regulatory pathways operating on monocyte and platelet membranes were investigated by comparing the cofactor function of thrombin-activated factor VIII to that of factor Xa-activated factor VIII. Reciprocal functional titrations with purified human factor VIII and factor IXa were performed at fixed concentrations of human monocytes, CaCl2, factor X, and either factor IXa or factor VIII. Factor VIII was preactivated with either thrombin or factor Xa, and reactions were initiated by addition of factor X. Rates of factor X activation were measured using chromogenic substrate specific for factor Xa. The K1/2 values, i.e., concentration of factor VIIIa at which rates were half maximal, were 0.96 nM with thrombin-activated factor VIII and 1.1 nM with factor Xa-activated factor VIII. These values are close to factor VIII concentration in plasma. The Vsat, i.e., rates at saturating concentrations of factor VIII, were 33.3 and 13.6 nM factor Xa/min, respectively. The K1/2 and Vsat values obtained in titrations with factor IXa were not significantly different from those obtained with factor VIII. In titrations with factor X, the values of Michaelis-Menten coefficients (Km) were 31.7 nM with thrombin-activated factor VIII, and 14.2 nM with factor Xa-activated factor VIII. Maximal rates were 23.4 and 4.9 nM factor Xa/min, respectively. The apparent catalytic efficiency was similar with either form of factor VIIIa. Kinetic profiles obtained with platelets as a source of membrane were comparable to those obtained with monocytes. These kinetic profiles are consistent with a 1:1 stoichiometry for the functional interaction between cofactor and enzyme on the surface of monocytes and platelets. Taken together, these results indicate that autocatalytic pathways connecting the extrinsic, intrinsic, and common coagulation pathways can operate efficiently on the monocyte membrane.
Autoimmune Regulator Aire: Evidence for Genetic Differences Between Autoimmune Hepatitis and Hepatitis As Part of the Autoimmune Polyglandular Syndrome Type 1
Authors: Arndt Vogel, Heike Liermann, Andrea Harms, Christian P. Strassburg, Michael P. Manns, Petra Obermayer-Straub
Journal: Hepatology (2001)

The mechanisms driving the immune-mediated destruction of hepatic tissues in autoimmune hepatitis (AIH) are unknown. Recently the autoimmune regulator (AIRE), a gene associated with the development of the autoimmune polyglandular syndrome type 1 (APS-1), was cloned. About 15% to 20% of APS-1 patients develop hepatitis. However, the role of AIRE mutations in AIH, primary sclerosing cholangitis (PSC), and primary biliary cirrhosis (PBC) is not known. To address this issue patients with AIH (n = 94), PSC (n = 60), and PBC (n = 30) were analyzed for the presence of mutations in exons 6, 8, and 10 of AIRE by single stranded conformation polymorphism and sequence analysis. Autoantibody patterns of patients with defects in AIRE were analyzed by indirect immunofluorescence, enzyme-linked immunosorbent assay and Western blot. Heterozygous mutations of AIRE were identified in 3 patients: a patient with PBC and a patient with AIH type 1 carried a R257X mutation, and a patient with AIH type 2, diabetes mellitus type 1 (IDDM), thyroid disease, and atrophic gastritis carried a G305S mutation in the first PHD ring finger domain of the AIRE protein. None of the 3 patients with a defective AIRE allele showed autoantibodies, which are known to associate with APS-1. These findings show a differential genetic association of autoimmune liver diseases and hepatitis in APS-1. The subgroup of patients with heterozygous mutations in AIRE does not represent patients with an incomplete APS-1 syndrome. However, the Aire gene defect showed that genes involved in the induction of immunologic tolerance provide candidates for etiologic factors in autoimmune liver diseases.
PARTURITION AS A FACTOR IN GYNECOLOGIC PRACTICE.
Authors: JOHN MILTON DUFF
Journal: JAMA (1900)

To convince gynecologists that parturition is not only a factor, but the principal factor, in producing morbidity which calls for their interference, no other argument is needed but the statistics of their own practice. Not having any special statistics at my command, I can not give the percentage of the cases of gynecic practice due directly or indirectly to parturition. They, of course, vary in different communities, as well as in the practice of different gynecologists. From what I can cull from general statistics, and from my own, as well as some statistics kindly furnished me by several gentlemen of large experience, I feel justified in saying that considerably over 50 per cent. of all gynecologic cases can be charged to parturition. The statistics furnished me vary very materially; the lowest are 55 per cent., and the highest 90 per cent., the average being about 66 per cent. The percentage
HLA system in relation to carbohydrate metabolism in lichen planus
Authors: SIMA HALEVY, RINA ZAMIR, EPHRAIM GAZIT, ELEASAR J. FEUERMAN
Journal: British Journal of Dermatology (1979)

HLA antigens were determined in a group of fifty-two patients with lichen planus. In the group as a whole the frequency of A28 was increased but not significantly so. When the patients were subdivided according to the results of an oral glucose tolerance test, however, a highly significant increase in the frequency of A28 was found among the non-diabetic patients.
Treatment of Otitis Externa and Swimmer's Ear
Authors: Ben H. Jenkins
Journal: JAMA (1961)

THE SUMMER SEASON invariably brings an increased incidence of external otitis. Most cases are bacterial in origin and generally of low virulence. The condition is prone to recur because of the peculiar structure of the auditory canal, which permits water and foreign material to enter and be retained. <h3>Pathology</h3> In about 70% of cases of external otitis, the predominant organism is<i>Pseudomonas aeruginosa</i>, a gram-negative organism. The remainder includes<i>Staphylococcus aureus, Staph. albus, Diphtheroids, Escherichia coli, Proteus vulgaris</i>, and a number of others. Maceration of the skin of the canal from water, trauma from foreign objects (particularly of organic character), and moist climatic conditions favor growth of fungi. Fungus infections of the external auditory canal have always presented a problem, since fungi resist most of the commonly used otitis preparations. Contrary to the layman's belief, however, most cases of so-called "fungus ear" are in reality bacterial infections, and fungi—when present—are
Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus
Authors: Tal I Arnon, Hagit Achdout, Ofer Levi, Gal Markel, Nivin Saleh, Gil Katz, Roi Gazit, Tsufit Gonen-Gross, Jacob Hanna, Efrat Nahari, Angel Porgador, Alik Honigman, Bodo Plachter, Dror Mevorach, Dana G Wolf, Ofer Mandelboim
Journal: Nature Immunology (2005)
Combined Flt3L/TK Gene Therapy Induces Immunological Surveillance Which Mediates an Immune Response Against a Surrogate Brain Tumor Neoantigen
Authors: Gwendalyn D King, AKM Ghulam Muhammad, Daniel Larocque, Kyle R Kelson, Weidong Xiong, Chunyan Liu, Nicholas SR Sanderson, Kurt M Kroeger, Maria G Castro, Pedro R Lowenstein
Journal: Molecular Therapy (2011)

Glioblastoma multiforme (GBM) is a primary brain tumor with a median survival of 14.6 months postdiagnosis. The infiltrative nature of GBM prevents complete resection and residual brain tumor cells give rise to recurrent GBM, a hallmark of this disease. Recurrent GBMs are known to harbor numerous mutations/gene rearrangements when compared to the primary tumor, which leads to the potential expression of novel proteins that could serve as tumor neoantigens. We have developed a combined immune-based gene therapeutic approach for GBM using adenoviral (Ads) mediated gene delivery of Herpes Simplex Virus Type 1-thymidine kinase (TK) into the tumor mass to induce tumor cells' death combined with an adenovirus expressing fms-like tyrosine kinase 3 ligand (Flt3L) to recruit dendritic cells (DCs) into the tumor microenvironment. This leads to the induction of specific anti-brain tumor immunity and immunological memory. In a model of GBM recurrence, we demonstrate that Flt3L/TK mediated immunological memory is capable of recognizing brain tumor neoantigens absent from the original treated tumor. These data demonstrate that the Flt3L/TK gene therapeutic approach can induce systemic immunological memory capable of recognizing a brain tumor neoantigen in a model of recurrent GBM. Glioblastoma multiforme (GBM) is a primary brain tumor with a median survival of 14.6 months postdiagnosis. The infiltrative nature of GBM prevents complete resection and residual brain tumor cells give rise to recurrent GBM, a hallmark of this disease. Recurrent GBMs are known to harbor numerous mutations/gene rearrangements when compared to the primary tumor, which leads to the potential expression of novel proteins that could serve as tumor neoantigens. We have developed a combined immune-based gene therapeutic approach for GBM using adenoviral (Ads) mediated gene delivery of Herpes Simplex Virus Type 1-thymidine kinase (TK) into the tumor mass to induce tumor cells' death combined with an adenovirus expressing fms-like tyrosine kinase 3 ligand (Flt3L) to recruit dendritic cells (DCs) into the tumor microenvironment. This leads to the induction of specific anti-brain tumor immunity and immunological memory. In a model of GBM recurrence, we demonstrate that Flt3L/TK mediated immunological memory is capable of recognizing brain tumor neoantigens absent from the original treated tumor. These data demonstrate that the Flt3L/TK gene therapeutic approach can induce systemic immunological memory capable of recognizing a brain tumor neoantigen in a model of recurrent GBM.
Tyk2 Plays a Restricted Role in IFNα Signaling, Although It Is Required for IL-12-Mediated T Cell Function
Authors: Kazuya Shimoda, Kouji Kato, Kenichi Aoki, Tadashi Matsuda, Akitomo Miyamoto, Masafumi Shibamori, Masakatsu Yamashita, Akihiko Numata, Ken Takase, Shinji Kobayashi, Shouichirou Shibata, Yoshinobu Asano, Hisashi Gondo, Kazuo Sekiguchi, Keiko Nakayama, Toshinori Nakayama, Takashi Okamura, Seiichi Okamura, Yoshiyuki Niho, Kei-ichi Nakayama
Journal: Immunity (2000)
Osler and the Tongue-Tied Medical Student
Authors: Henry R. Viets
Journal: New England Journal of Medicine (1959)

For his bounty,There was no winter in't; an autumn 'twas That grew the more by reaping: his delights Were dolphin-like, they showed his back above The element they lived in... Ant. & Cleo. 5:2, 86–90.THE two qualities of William Osler that stand out most clearly forty years after his death, in addition to his great intellectual achievements, are his sunny disposition that had "no winter in't" and "grew the more by reaping" and the dolphin-like delights that frequently flashed up from the strict environment in which he lived. Both these elements are recalled by an incident that . . .
Continuous affective states recognition using functional near infrared spectroscopy
Authors: Dominic Heger, Christian Herff, Felix Putze, Reinhard Mutter, Tanja Schultz
Journal: Brain-Computer Interfaces (2014)

Monitoring the affective states of a person can be highly relevant for numerous disciplines, including adaptive user interfaces, entertainment, ergonomics, medicine and therapy. In many situations, the affective state of a user is not easily observable from outside by audio or video, but may be identified by a brain-computer interface (BCI). Functional near-infrared spectroscopy (fNIRS) is a brain imaging modality gaining rising attention in the BCI community. However, fNIRS emotion recognition studies have only analyzed stimulus-locked effects. For realistic human-machine interaction scenarios, the point of time of an emotion-triggering event and the time span of an affective state are unknown. In this paper, we investigate a BCI that monitors the affective states of the user continuously over time (i.e. asynchronous BCI). In our study, fNRIS signals from eight subjects have been recorded at eight prefrontal locations in response to three different classes of affect induction by emotional audio-visual stimuli plus a neutral class. Our system evaluates short windows of 5 s length to continuously recognize affective states. We analyze hemodynamic responses, present a careful evaluation of binary classification tasks, compare time-domain and wavelet-based signal features, and investigate classification accuracies over time.
Clinical Management of Seizures: A Guide for the Physician
Authors: Harold E. Booker
Journal: JAMA (1976)

The authors intend this book to be a guide to the clinical management of seizure disorders for "physicians, residents, and medical students who are not specialists in Neurology." To serve this purpose in a practical way, any such book must be brief and yet comprehensive. To meet these ends, and to allow for more discussion of clinical matters, the authors have taken a didactic approach that avoids discussion of unsettled or controversial areas, abbreviates discussion of pathophysiology and metabolism, and substitutes a "selective bibliography" for more extensive referencing. Appropriate attention is given to the necessity for diagnosing the underlying cause of the seizures in all cases. Unfortunately, the emphasis the authors give to focal seizures in adults in this regard could lead to the erroneous implication that continuing search for a treatable lesion is not important in patients with generalized seizures. The discussion of the unusual nature, causes, and treatment
Prevention of glucocorticoid induced osteoporosis
Authors: J. W J BIJLSMA
Journal: Annals of the Rheumatic Diseases (1997)

Most physicians are well aware that osteoporosis is one of the major complications of glucocorticoid treatment. Only a limited number of physicians, however, simultaneously prescribe medication to prevent the occurrence of glucocorticoid induced osteoporosis. Daily practice (in Europe) was recently evaluated in the area of Nottinghamshire in the United Kingdom.1 A community survey was carried out to determine the prevalence of continuous use of oral corticosteroids and simultaneous treatment to prevent osteoporosis. This survey covered a population of over 65 000 inhabitants; 303 patients, representing 0.5% of the population, had been taking oral corticosteroids for at least three months. The mean dose was 8 mg prednisolone daily, the medium duration of treatment was three years. In the course of four years only 41 of these 303 patients (14%) had received medication to prevent osteoporosis. In a large teaching hospital in the UK calcium supplementation was prescribed for only 6% of the patients treated with corticosteroids.2 These data clearly illustrate that measures to prevent glucocorticoid induced osteoporosis are not common in daily practice.

In clear contrast with this daily practice are the recent recommendations published by the American College of Rheumatology Task Force on Osteoporosis Guidelines.3 These guidelines are quite clear. For patients starting long term glucocorticoid treatment, bone mineral density (BMD) measurements should be performed. The BMD of a patient may be expressed as a T score (the difference in standard deviation (SD) with respect to the peak bone mass in a young adult of the same race and sex) or a Z score (the difference in SD with respect to that found for healthy age matched controls of the same race and sex). Patients with a BMD 1 SD or more below the peak bone mass (that is, T score <−1) are considered to have a low …
Ultrastructure of synovial membrane in rheumatoid arthritis.
Authors: F N Ghadially, S Roy
Journal: Annals of the Rheumatic Diseases (1967)

Many reports describing the electron microscopic appearance of normal synovial membrane have appeared in the literature in recent years.Two types of lining cells (Type A and B) are seen in synovial membrane of man (Barland, Novikoff, and Hamerman, 1962; Roy, Ghadially, and Crane, 1966), rabbit (Ghadially and Roy, 1966), guinea-pig (Wyllie, More, and Haust, 1964) and rat (Roy and Ghadially, 1967).Reports on the ultrastructure of rheumatoid synovium are comparatively fewer.Barland, Novikoff, and Hamerman (1964), in a study restricted to the lining cells, observed many changes in Type A cells but the Type B cells ap- peared normal.However Wyllie, Haust, and More (1966) described, in addition to the changes in the Type A cell, an increase in the number of Type B cells in rheumatoid synovium.Structural alterations have been observed in the vascular endothelium of the rheumatoid synovium by Hirohata and Kobayashi (1964) which however could not be confirmed in the study of Norton and Ziff (1966).Highton, Caughey, and Rayns (1966) described the presence of rod-shaped inclusions in vascular endothelial cells in rheumatoid synovium, these authors failed to see such bodies in the synovial vessels in normal individuals or in cases of torn meniscus.--..
Countdown to 2015 decade report (2000–10): taking stock of maternal, newborn, and child survival
Authors: Zulfiqar A Bhutta, Mickey Chopra, Henrik Axelson, Peter Berman, Ties Boerma, Jennifer Bryce, Flavia Bustreo, Eleonora Cavagnero, Giorgio Cometto, Bernadette Daelmans, Andres de Francisco, Helga Fogstad, Neeru Gupta, Laura Laski, Joy Lawn, Blerta Maliqi, Elizabeth Mason, Catherine Pitt, Jennifer Requejo, Ann Starrs, Cesar G Victora, Tessa Wardlaw
Journal: The Lancet (2010)
Human Behavior, Medicine and Social Reform
Authors: Vernon D. Patch
Journal: New England Journal of Medicine (1969)

The medical treatment of disorders of human behavior has not distinguished itself with scientific success. Students of the etiology of antisocial behavior have produced more theories in explanation than facts in clarification. Specifically, drug addiction, an antisocial disorder of human behavior, has been seen as both sickness and "badness"; it has been treated as sickness by social reformers and as "badness" by a punitive society, rarely simultaneously and in co-operation. The nature versus nurture controversy has droned on endlessly without resolution. The questions are posed and remain unanswered. Was this patient's troublesome behavior inbred, or was the behavior learned by . . .
14–3-3 integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1–transformed hematopoietic cells
Authors: Shaozhong Dong, Sumin Kang, Ting-Lei Gu, Sean Kardar, Haian Fu, Sagar Lonial, Hanna Jean Khoury, Fadlo Khuri, Jing Chen
Journal: Blood (2007)
Our Debt to Aristotle
Authors: L. J. MOORMAN
Journal: Annals of Internal Medicine (1929)

Article1 May 1929Our Debt to AristotleL. J. MOORMAN, M.D., F.A.C.P.L. J. MOORMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-11-1216 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThree hundred and eighty-four years before Christ came to Bethlehem Aristotle was a babe in ancient Macedonia. From the womb of Phoestis had sprung the master mind of all ages "The sovereign lord of the understanding." Two and a half centuries before Saint Paul received the call for help in Macedonia, this little kingdom, resting quietly on the fringe of Athenian glory, had sent into the world the first evangel of natural history and the rightful progenitor of all the positive sciences: The author of logical thinking and the stabilizer of metaphysics.Aristotle was born in the little town of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: L. J. MOORMAN, M.D., F.A.C.P.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1929Volume 2, Issue 11Page: 1216-1222KeywordsUterus ePublished: 1 December 2008 Issue Published: 1 May 1929 PDF downloadLoading ...
Major ocular trauma: a disturbing trend in field hockey injuries.
Authors: A J Elliott, D Jones
Journal: BMJ (1984)

function during prolonged treatment with captopril suggests that some of the renal impairment observed before treatment might be due to a functional disorder.We recommend close monitoring of renal function at the start of treatment with captopril in patients with chronic renal failure and severe arterial hypertension.Anonymous.Captopril: benefits and risks in severe hypertension [Editorial).
Cardiovascular State of Newly Discovered Diabetic Women
Authors: J. A. Weaver, S. K. Bhatia, D. Boyle, D. R. Hadden, D. A. D. Montgomery
Journal: BMJ (1970)

A cardiovascular study of a group of 90 newly diagnosed diabetic women aged 35 to 75 years was begun in 1965 and a repeat examination was carried out on the same patients in 1968. A high prevalence of ischaemic heart disease was found in these patients at the time of diagnosis, and this finding had some predictive value as regards prognosis over the three-year period.A comparative study with general medical outpatients and long-established diabetics (greater than 10 years' duration of disease) confirmed the high prevalence of ischaemic heart disease in late-onset mild diabetics controlled by diet or oral drugs. It is suggested that this type of milder diabetic patient contributes in undue proportion to the high prevalence of ischaemic heart disease in diabetes.