Low Rate of Venous Thromboembolism in Asymptomatic Relatives of Probands with Factor V Leiden Mutation
Authors: Paolo Simioni
Journal: Annals of Internal Medicine (1999)

Letters16 March 1999Low Rate of Venous Thromboembolism in Asymptomatic Relatives of Probands with Factor V Leiden MutationPaolo Simioni, MD, PhD, Paolo Prandoni, MD, PhD, and Antonio Girolami, MDPaolo Simioni, MD, PhDUniversity of Padua Medical School; 35128 Padua, Italy (Simioni)University of Padua Medical School; 35128 Padua, Italy (Prandoni)University of Padua Medical School; 35128 Padua, Italy (Girolami), Paolo Prandoni, MD, PhDUniversity of Padua Medical School; 35128 Padua, Italy (Simioni)University of Padua Medical School; 35128 Padua, Italy (Prandoni)University of Padua Medical School; 35128 Padua, Italy (Girolami), and Antonio Girolami, MDUniversity of Padua Medical School; 35128 Padua, Italy (Simioni)University of Padua Medical School; 35128 Padua, Italy (Prandoni)University of Padua Medical School; 35128 Padua, Italy (Girolami)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-6-199903160-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The risk for venous thromboembolism in asymptomatic carriers of factor V Leiden mutation is still being debated (1). To estimate this risk, we performed a prospective cohort study in 417 family members of 64 symptomatic patients with single identified factor V Leiden mutation. All participants underwent genetic determination of this mutation and were followed for an average of 2.8 years (range, 1.8 to 3.8 years). Any clinically suspected thromboembolic episode was objectively documented with standard methods. There were 614 observation-years in 216 carriers of factor V Leiden mutation (206 heterozygous and 10 homozygous) and 583 observation-years in ...References1. Middeldorp S, Henkens CM, Koopman MM, van Pampus EC, Hamulyák K, van der Meer J, et al . The incidence of venous thromboembolism in family members of patients with factor V Leiden mutation and venous thrombosis. Ann Intern Med. 1998;128:15-20. LinkGoogle Scholar2. Hansson PO, Werlin L, Tibblin G, Eriksson H. Deep vein thrombosis and pulmonary embolism in the general population. Arch Intern Med. 1997;157:1665-70. CrossrefMedlineGoogle Scholar3. Ryan DH, Crowther MA, Ginsberg JS, Francis CW. Relation of factor V Leiden genotype to risk for acute deep venous thrombosis after joint replacement surgery. Ann Intern Med. 1998;128:270-6. LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Padua Medical School; 35128 Padua, Italy (Simioni)University of Padua Medical School; 35128 Padua, Italy (Prandoni)University of Padua Medical School; 35128 Padua, Italy (Girolami) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA prospective cohort study on the absolute incidence of venous thromboembolism and arterial cardiovascular disease in asymptomatic carriers of the prothrombin 20210A mutationThe incidence of venous thromboembolism among Factor V Leiden carriers: a community-based cohort studyEstrogen-containing oral contraceptives are allowable in young women with factor V Leiden heterozygosity without a history of thrombosisLaboratory Evaluation of Hypercoagulability With Venous or Arterial ThrombosisIncidence of venous thromboembolism in asymptomatic family members who are carriers of factor V Leiden: a prospective cohort studyA Prospective Study of Asymptomatic Carriers of the Factor V Leiden Mutation To Determine the Incidence of Venous ThromboembolismSaskia Middeldorp, MD, Johan R. Meinardi, MD, Maria M.W. Koopman, MD, Elisabeth C.M. van Pampus, MD, Karly Hamulyák, MD, Jan van der Meer, MD, Martin H. Prins, MD, and Harry R. Büller, MDGenetic hypercoagulability: screening should be an informed choicePulmonary Embolism After Elective Glenohumeral Joint DebridementHomozygous Patients With the 20210 G to A Prothrombin Polymorphism Remain Often Asymptomatic in Spite of the Presence of Associated Risk FactorsProthrombotic Activity of Oral Contraceptives in Patients With Congenital Thrombophilia Varies With the DefectThe Significance or Nonsignificance of the G to A 20210 Prothrombin PolymorphismState-of-the-Art Review : G to A 20210 Prothrombin Polymorphism and Venous Thrombosis: Simple Association or Causal Relationship? 16 March 1999Volume 130, Issue 6Page: 538KeywordsFactor V LeidenGenetic determinismMedical risk factorsOral contraceptive therapyPregnancyRelative riskThromboembolismThrombosisTrauma surgeryVenous thromboembolism Issue Published: 16 March 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...