Small Dense Low-Density Lipoprotein in Japanese Men with Coronary Artery Disease
Authors: Shinji Koba, Tsutomu Hirano
Journal: Annals of Internal Medicine (2000)

Letters2 May 2000Small Dense Low-Density Lipoprotein in Japanese Men with Coronary Artery DiseaseShinji Koba, MD and Tsutomu Hirano, MDShinji Koba, MDShowa University School of Medicine; Tokyo 142-8666, Japan (Koba)Showa University School of Medicine; Tokyo 142-8666, Japan (Hirano)Search for more papers by this author and Tsutomu Hirano, MDShowa University School of Medicine; Tokyo 142-8666, Japan (Koba)Showa University School of Medicine; Tokyo 142-8666, Japan (Hirano)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-9-200005020-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Recent studies have demonstrated that small dense low-density lipoprotein (LDL) is highly atherogenic and that the prevalence of this LDL phenotype (pattern B) is a risk factor for coronary artery disease (CAD) (1, 2). We measured mean LDL particle diameter by using nondenatured gradient polyacrylamide gel in Japanese persons, an ethnic group with relatively low serum cholesterol levels and a considerably lower incidence of CAD (3-5).We enrolled consecutive male patients younger than 80 years of age who were admitted to our hospital from April to June 1999. We excluded patients with diabetes mellitus, liver disease, infectious ...References1. Gardner CD, Fortmann SP, Krauss RM. Association of small dense low-density lipoprotein particles with the incidence of coronary artery disease in men and women. JAMA. 1996;276:875-81. CrossrefMedlineGoogle Scholar2. Lamarche B, Tchernof A, Mauriege P, Cantin B, Dagenais GR, Lupien PJ, et al . Fasting insulin and apolipoprotein B levels and low-density lipoprotein particle size as risk factors for ischemic heart disease. JAMA. 1998;279:1955-61. CrossrefMedlineGoogle Scholar3. Wakugami K, Iseki K, Kimura Y, Okumura K, Ikemiya Y, Muratani H, et al . Relationship between serum cholesterol and the risk of acute myocardial infarction in a screened cohort in Okinawa, Japan. Jpn Circ J. 1998;62:7-14. CrossrefMedlineGoogle Scholar4. Ginsburg GS, Safran C, Pasternak RC. Frequency of low serum high-density lipoprotein cholesterol levels in hospitalized patients with desirable total cholesterol levels. Am J Cardiol. 1991;68:187-92. CrossrefMedlineGoogle Scholar5. Kubota I, Ito H, Yokoyama K, Yasumura S, Tomoike H. Early mortality after acute myocardial infarction: observational study in Yamagata, 1993-1995. Jpn Circ J. 1998;62:414-8. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Shinji Koba, MD; Tsutomu Hirano, MDAffiliations: Showa University School of Medicine; Tokyo 142-8666, Japan (Koba)Showa University School of Medicine; Tokyo 142-8666, Japan (Hirano) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRole of small dense LDL-cholesterol in detecting the risk of cardiovascular disease among smokersSmall dense LDL cholesterol measured by homogeneous assay in Japanese healthy controls, metabolic syndrome and diabetes patients with or without a fatty liverLow-density Lipoprotein Cholesterol/Apolipoprotein B Ratio May Be a Useful Index That Differs in Statin-Treated Patients With and Without Coronary Artery DiseaseRelationship between Two AMI Risk Factors: Low Serum Lipoprotein Lipase Mass and HypoadiponectinemiaComparison of the Effect of Cilostazol with Aspirin on Circulating Endothelial Progenitor Cells and Small-Dense LDL Cholesterol in Diabetic Patients with Cerebral Ischemia: A Randomized Controlled Pilot TrialDetermination of Low Density Lipoprotein Particle Size by Polyacrylamide Gradient Gel Electrophoresis in Patients with Coronary Artery StenosisCircadian change of serum concentration of small dense LDL-cholesterol in type 2 diabetic patientsSmall dense low-density lipoprotein cholesterol concentration and carotid atherosclerosisClinical Significance of Serum 7-Ketocholesterol Concentrations in the Progression of Coronary AtherosclerosisSerum concentration of small dense low-density lipoprotein-cholesterol during oral glucose tolerance test and oral fat tolerance testEffect of the Angiotensin II Receptor Antagonist Telmisartan on Lipoprotein Lipase Mass in Preheparin SerumCircadian rhythm of serum concentration of small dense low-density lipoprotein cholesterolSignificance of small dense low-density lipoprotein-cholesterol concentrations in relation to the severity of coronary heart diseasesEffect of nateglinide on the size of LDL particles in patients with type 2 diabetesPredominance of Small Dense Low-Density Lipoproteins and Abnormal Glucose Regulation in Patients With Acute Coronary SyndromeLow-Density Lipoprotein Subfractions and the Prevalence of Silent Lacunar Infarction in Subjects with Essential HypertensionPostprandial changes in LDL phenotypes in patients with myocardial infarctionMeasurement of Small Dense Low-density Lipoprotein ParticlesStrange PhospholipidsSmall dense low-density lipoprotein and carotid atherosclerosis in relation to vascular dementiaClinical Significance of Small Dense Low-Density Lipoprotein Cholesterol Levels Determined by the Simple Precipitation MethodAssociation Between Small Dense Low-Density Lipoprotein and Postprandial Accumulation of Triglyceride-Rich Remnant-Like Particles in Normotriglyceridemic Patients With Myocardial InfarctionA novel and simple method for quantification of small, dense LDLSignificance of small dense low-density lipoproteins and other risk factors in patients with various types of coronary heart diseaseHMG-CoA reductase inhibitor decreases small dense low-density lipoprotein and remnant-like particle cholesterol in patients with type-2 diabetesAn increased number of very-low-density lipoprotein particles is strongly associated with coronary heart disease in Japanese men, independently of intermediate-density lipoprotein or low-density lipoproteinRemarkably high prevalence of small dense low-density lipoprotein in Japanese men with coronary artery disease, irrespective of the presence of diabetesAtherogenic lipoproteins and diabetes mellitusAssociation between Preheparin Serum Lipoprotein Lipase Mass and Acute Myocardial Infarction in Japanese MenRisk Factors for Coronary Heart Disease in the Japanese &mdash; Comparison of the Background of Patients with Acute Coronary Syndrome in the ASPAC Study with Data Obtained from the General PopulationTreatment of Small Dense LDLSignificance of Small Dense Low-Density Lipoproteins in Coronary Heart Disease 2 May 2000Volume 132, Issue 9Page: 762KeywordsCholesterolHigh density lipoproteinInfectious diseasesInsulinLiver diseasesLow density lipoproteinMedical risk factorsPhenotypesRegression analysisStable coronary artery disease ePublished: 15 August 2000 Issue Published: 2 May 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. 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