tbuckley/cabot-search huggingface dataset:
TGF-? receptor function in the endothelium
Authors: F LEBRIN, M DECKERS, P BERTOLINO, P TENDIJKE
Journal: Cardiovascular Research (2004)

Genetic studies in mice and humans have revealed the pivotal role of transforming growth factor-beta (TGF-beta) signaling during angiogenesis. Mice deficient for various TGF-beta signaling components present an embryonic lethality due to vascular defects. In patients, mutations in the TGF-beta type I receptor ALK1 or in the accessory TGF-beta receptor endoglin are linked to an autosomal dominant disorder of vascular dysplasia termed Hereditary Haemorrhagic Telangiectasia (HHT). It has puzzled researchers for years to explain the effects of TGF-beta being a stimulator and an inhibitor of angiogenesis in vitro and in vivo. Recently, a model has been proposed in which TGF-beta by binding to the TGF-beta type II receptor can activate two distinct type I receptors in endothelial cells (ECs), i.e., the EC-restricted ALK1 and the broadly expressed ALK-5, which have opposite effects on ECs behavior. ALK1 via Smad1/5 transcription factors stimulates EC proliferation and migration, whereas ALK5 via Smad2/3 inhibits EC proliferation and migration. Here, the new findings are presented concerning the molecular mechanisms that take place in ECs to precisely regulate and even switch between TGF-beta-induced biological responses. In particular, the role of the accessory TGF-beta receptor endoglin in the regulation of EC behavior is addressed and new insights are discussed concerning the possible mechanisms that are implicated in the development of HHT.
Personality Structure of Asthmatic and Normal Children Assessed hy the Rorschach Technique
Authors: Asbjorn O. Faleide, Anne L. Refnin, Reidulf G. Watten
Journal: Psychotherapy and Psychosomatics (1988)

This paper presents the results of a Rorschach assessment of a group of children with severe asthma (n = 21) compared to a control group (n = 21) of normal school children, matched for age and intellectual abilities. The design allows comparable data on total responses, movement, forms, color and other determinants. The mode of perception differs significantly between the groups. These differences will be discussed according to old hypotheses of personality traits as causative factors in the etiology of asthma.
Augmented Peripheral Chemosensitivity as a Potential Input to Baroreflex Impairment and Autonomic Imbalance in Chronic Heart Failure
Authors: Piotr Ponikowski, Tuan Peng Chua, Massimo Piepoli, Daniela Ondusova, Katharine Webb-Peploe, Derek Harrington, Stefan D. Anker, Maurizio Volterrani, Roberto Colombo, Giorgio Mazzuero, Amerigo Giordano, Andrew J. S. Coats
Journal: Circulation (1997)

The precise mechanisms responsible for the sympathetic overactivity and blunted baroreflex control in chronic heart failure (CHF) remain obscure. Augmented peripheral chemosensitivity has recently been demonstrated in CHF. We evaluated the relation between peripheral chemoreflex sensitivity and autonomic activity in patients with CHF.We studied in 26 stable patients with CHF the peripheral chemosensitivity (ventilatory response to hypoxia using transient inhalations of pure nitrogen), autonomic balance (spectral analysis of heart rate variability [HRV]), and baroreflex sensitivity (bolus phenylephrine method and alpha index). To determine whether transient inactivation of peripheral chemoreceptors might influence autonomic balance, 12 patients underwent a second study during which they breathed 100% O2. Peripheral chemosensitivity correlated inversely with HRV power within the low-frequency band (0.04 to 0.15 Hz) (r=-.52, P=.006) and inversely with baroreflex sensitivity (r=-.60, P=.005). When the patients were divided into two groups according to the chemosensitivity of age-matched normal controls (above and below mean+2 SDs of chemosensitivity of control subjects), those above the normal range revealed more impaired autonomic balance, ie, lower baroreflex sensitivity (1.4 +/- 1.3 versus 5.0 +/- 1.5 ms/mm Hg, P<.0001) and depressed values of low-frequency power (2.5 +/- 1.8 versus 4.1 +/- 0.8 ln ms2, P<.005) compared with those with normal chemosensitivity. Transient hyperoxia did not alter heart rate or systolic pressure but resulted in an increase in HRV and an improvement in baroreflex sensitivity.A link between increased peripheral chemosensitivity and impaired autonomic control, including baroreflex inhibition, is demonstrated. The clinical importance of this phenomenon warrants further investigation.
Reply to Pascal Mouracade’s Letter to the Editor re: Rustom P. Manecksha, Ivor M. Cullen, Sarfraz Ahmad, et al. Prospective Randomised Controlled Trial Comparing Trigone-Sparing versus Trigone-Including Intradetrusor Injection of AbobotulinumtoxinA for Refractory Idiopathic Detrusor Overactivity. Eur Urol 2012;61:928–35
Authors: Rustom P. Manecksha, Ivor M. Cullen, Sarfraz Ahmad, Graeme McNeill, Robert Flynn, Thomas E.D. McDermott, Ronald Grainger, John A. Thornhill
Journal: European Urology (2011)
335 Interim results of a randomized trial of 1.5μG/ KG vs. 3.0 μG/KG pegylated interferon alfa 2-B PEG-intron(R) (PEG) plus ribavirin (RBV) for naïve chronic hepatitis C patients and 3.0μG/KG PEG plus RBV for non-responders (NR) and relapsers (R) to previous therapy. (The target trial)
Authors: C WHITE, P MALET, C WENTWORTH, V CANTU, T ALTON, W LEE
Journal: Hepatology (2003)
Safety of piped medical gases and electromedical equipment.
Authors: C S Ward
Journal: BMJ (1979)

ing.Medical journals in particular should stop immediately the implicit advertising of alcohol which often appears in their pages concerned with eating out and such recreations.It is not long since in Birmingham the BMA itself arranged a whisky tasting evening.On the other hand, with heroin we have created a "pushers' market," and our methods for handling this problem are those which have proved disastrous in America in respect of the prohibition of alcohol.In the case of alcohol
A Practical Two-Step Quantitative Clinical and Electrophysiological Assessment for the Diagnosis and Staging of Diabetic Neuropathy
Authors: Eva L Feldman, M J Stevens, P K Thomas, M B Brown, N Canal, D A Greene
Journal: Diabetes Care (1994)

OBJECTIVE Early diagnosis of distal symmetric sensorimotor polyneuropathy, a common complication of diabetes, may decrease patient morbidity by allowing for potential therapeutic interventions. We have designed an outpatient program to facilitate diagnosis of diabetic neuropathy. RESEARCH DESIGN AND METHODS Patients are initially administered a brief questionnaire and screening examination, designated the Michigan Neuropathy Screening Instrument (MNSI). Diabetic neuropathy is confirmed in patients with a positive assessment by a quantitative neurological examination coupled with nerve conduction studies, designated the Michigan Diabetic Neuropathy Score (MDNS). In this study, 56 outpatients with confirmed type I or II diabetes were administered the standardized quantitative components required to diagnose and stage diabetic neuropathy according to the San Antonio Consensus Statement (1) and the Mayo Clinic protocol (2). These same patients were then assessed with the MNSI and the MDNS. RESULTS Of 29 patients with a clinical MNSI score &amp;gt; 2, 28 had neuropathy. Twenty-eight patients with an MDNS of ≥ 7 had neuropathy, while 21 non-neuropathic patients had a score ≤ 6. Of 35 patients with diabetic neuropathy, 34 had ≥ 2 abnormal nerve conductions. Twenty-one normal patients and one patient with neuropathy had ≤ 1 abnormal nerve conduction. CONCLUSIONS The results indicate that the MNSI is a good screening tool for diabetic neuropathy and that the MDNS coupled with nerve conductions provides a simple means to confirm this diagnosis.
Studies of Adolescents Indicate Just How Complex the Situation Is for This Age Group
Authors: Timothy F. Kirn
Journal: JAMA (1989)

NOT SURPRISINGLY, participants at the Society for Adolescent Medicine's recent meeting often discussed drug abuse and sexual behaviors and diseases. In the keynote address, Robert Haggarty, MD, president of the William T. Grant Foundation, New York, NY, said there appears to be growing evidence that much of what is labeled "problem behavior" among young people—teen pregnancies, school dropouts, delinquency, and drug abuse—is related to economic difficulties and a resultant pessimistic view of the future. Some other studies presented at the meeting suggest: Peer pressure may be overrated, according to Seth Ammerman, MD, a second-year fellow in the Division of Adolescent Medicine at the University of California, San Francisco. Ammerman surveyed 163 adolescents at an urban high school, asking about their motivations for engaging in "high-risk" behavior, such as drug taking, drinking, smoking, and sex. What is most important, Ammerman says, is that only the abstainers (who usually cited health reasons)
Encounters Between Patients and Doctors: An Anthology
Authors: Richard E. Peschel
Journal: JAMA (1987)

In his 1934 address at the Harvard Medical School Colloquium, entitled "Physician and Patient as a Social System" (and reproduced in this excellent collection of essays and reports), L. J. Henderson stated: "In your relations with your patients you will inevitably do much harm, and this will be by no means confined to your strictly medical blunders. It will arise also from what you say and what you fail to say." While modern medicine has made enormous technological advances in the last 50 years, the physician-patient relationship remains a complex and crucial (if sometimes neglected) part of medical care. Dr Stoeckle's anthology,<i>Encounters Between Patients and Doctors</i>, provides medical students and practicing physicians with a sound introduction to the depth and breadth of original studies written on the relations between physicians and patients. This book is ambitious, since it presents original essays on the structure, dynamics, nature, modes of communication,
HERNIA OR DIVERTICULUM OF THE CHORION.
Authors: L. H. LAIDLEY
Journal: JAMA (1900)

Cysts of the placenta have been reported by Millet and others, supposed to have developed from the exudation of blood forming a clot separating the chorion, usually of small size, and in some cases more than one is noted. Ercolani reported two cases; in one the entire fetal surface of the placenta was sown with round tumors covered by chorion—the largest being about the size of a cherry. Some have been opened and the chorionic wall torn, showing a solid material filling the depth of the cyst; others were more solid, and were filled with coagulated fibrin, in which rounded masses of granular hematin could be seen. Ercolani proved that the interior wall was formed by the chorion, which covered the whole bloody mass, of which half projected above the placental surface, while half dipped into the placental tissue, and lay in immediate contact with the effused blood. The term
From axis to triangle: The role of orbital cortex
Authors: Mihail Bota
Journal: Behavioral and Brain Sciences (2003)

This commentary focuses on the “olfactory cortices–hippocampal formation” axis, proposed by Aboitiz et al. to be that network which allowed the first mammals to create elaborate representations of space. I argue here that this neural axis can be extended to a triangle of structures which also includes the orbital cortex.
ACCURATE EVALUATION OF VENIRICULAR VOLIMES WITH GATED CARDIAC SCANS USING A DIRECT MEASUREMENT OF PHD ATTENUATION (PAT)
Authors: Osman Ratib, Ebethard Henze, Hukus Schwaiger, Katly Drakup, Jan Tillisch, Heinich Schelbert
Journal: Clinical Nuclear Medicine (1981)

Ratib, Osman; Henze, Ebethard; Schwaiger, Hukus; Drakup, Katly; Tillisch, Jan; Schelbert, Heinich Author Information
The spectrum of complement-fixing antinuclear antibodies in patients with hepatocellular carcinoma
Authors: Kendo Kiyosawa, Richard J. Daemer, Li-Fang He, Ferruccio Bonino, O. W. Prozesky, Robert H. Purcell
Journal: Hepatology (1985)

Sera from 230 hepatocellular carcinoma patients were tested for antinuclear antibodies by anticomplement immunofluorescence in 16 types of transformed, diploid or primary cells of human, monkey, chimpanzee or rat origin. As controls, we tested 85 sera from patients with chronic liver diseases, 48 sera from patients with nonhepatic cancers and 164 sera of normal controls. Exactly 11.2% of all cancer patients but only 3.6% of noncancer patients had complement-fixing antinuclear antibody that reacted with all substrates. Only sera from hepatocellular carcinoma reacted with subsets of the tumor cell substrates. These sera reacted with hepatocellular carcinoma cells and nonhepatic cancer cells (antitumor) or only with one or more of the human hepatocellular carcinoma cell lines, PLC/PRF/5, Hep3B and Mahlavu, that were derived from HBsAg-positive patients (antihepatocellular carcinoma). Three of these reacted only with hepatitis B virus DNA-positive cells (PLC/PRF/5 and Hep3B) that contained “hepatitis B-associated nuclear antigen,” 1 reacted only with hepatitis B virus DNA-negative Mahlavu cells, 1 reacted with PLC/PRF/5 and Mahlavu and 3 reacted with all 3 cells. The nuclear antigen in Mahlavu was expressed as a homogeneous fluorescence that spared the nucleoli, was present in a lower percentage of cells than hepatitis B-associated nuclear antigen and was more thermostable than hepatitis B-associated nuclear antigen. However, it resembled hepatitis B-associated nuclear antigen in kinetics of expression and susceptibility to digestion with DNase, RNase and proteinase K. The nature of the nuclear antigens in the hepatocellular carcinoma cells is poorly understood but one possibility is that they may represent the expression of viral or tumor-related genes. We found also tumor cell-specific nuclear antigens in tumor cell lines. These antigens might represent the expression of cellular transforming genes.
Identification of<i>PFTAIRE</i>protein kinase 1, a novel cell division cycle-2 related gene, in the motile phenotype of hepatocellular carcinoma cells
Authors: Etonia Y‐T. Pang, Alfa H‐C. Bai, Ka‐Fai To, Shirley M‐H. Sy, Navy L‐Y. Wong, Paul B‐S. Lai, Jeremy A. Squire, Nathalie Wong
Journal: Hepatology (2007)

Metastasis is a major cause of cancer morbidity and mortality in individuals with hepatocellular carcinoma (HCC), yet little is known about the underlying molecular basis. Using genetic information derived from chromosome-based comparative genomic hybridization, we have reported previously on regional chromosome 7q21-q22 gains in close association with HCC progression. In this study, we undertook cDNA microarray-based comparative genomic hybridization, to examine the 7q21-q22 region for the involved gene(s) in HCC. High-resolution mapping analysis highlighted 7 candidates, namely PFTAIRE protein kinase 1 (PFTK1), ODAG, CDK6, CAS1, PEX1, SLC25A, and PEG10, within the region. Quantitative reverse transcription (RT)-PCR evaluation further indicated upregulation of a single candidate gene, PFTK1, that correlated significantly with both advanced metastatic HCCs (P = 0.032) and tumor microvascular invasion (P = 0.012). Given that little is known about the function(s) of PFTK1, which is a novel cell division cycle (Cdc)2-related gene, we examined its potential role in the motile phenotype of HCC cells by both ectopic expression and knockdown investigations. RNA-interference knockdown of PFTK1 in invasive Hep3B cells resulted in a significant reduction in cell invasion, chemotactic migration, and cell motility (P < 0.001). Conversely, ectopic expression of PFTK1 in noninvasive HKCI-C3 cells induced substantial cellular invasion and migration (P < or = 0.007). In neither cell line was there any effect on cell viability. Immunofluorescence showed marked filamentous actin polymerizations in PFTK1-expressing cells.In this study, we have thus provided preliminary evidence that overexpression of PFTK1 may confer a motile phenotype in malignant hepatocytes that accounts for the association of upregulation of this gene in metastatic HCC.
Torsion of Spleen With Spontaneous Rupture of Splenic Vein Presenting as a Case of Accidental Haemorrhage
Authors: C. S. Seah, N. C. Tan
Journal: BMJ (1964)

MCAOAL DISCUSSIONAlthough fungal meningitis is particularly associated with the debilitation of malignant disease, no such association has been demonstrated with meningitis caused by L. monocytogenes (Nichols and Woolley, 1962).The peak incidence of listeria meningitis is in infancy, but there is a lesser peak in late adult life.Bacteraemia may follow prostatectomy, and subacute bacterial
ENDOTHELIOMA OF THE PITUITARY GLAND WITH INFANTILISM
Authors: G. E. Rennie
Journal: BMJ (1912)

THE following case, which.was under my care in the Royal Prince Alfred Hospital, Sydney, on two occasions, is of special interest in view of the present divergence of opinion upon the true functions of the pituitary gland.A boy, 16 years of age, a telegraph messenger, was admitted to hospital in 1907, with a history of headache for some considerable time, accompanied by a feeling of drowsiness and disinclination for any kind of food, with s in e wasting.His height was 4 ft.8 in., a n d weight 4 st.5-1 lb.History.
Role of endogenous nitric oxide in asthma
Authors: G. U. Di Maria, L. Spicuzza, A. Mistretta, G. Mazzarella
Journal: Allergy (2000)

Endogenous nitric oxide (NO) is an ubiquitous signaling molecule with important regulatory functions such as regulation of blood pressure, neurotransmission, and host and immune defense. In the respiratory tract, NO is formed and released by various sources including endothelial and epithelial cells, nerves, airway smooth muscle, and inflammatory cells. Recent evidence suggests that endogenous NO is the neurotransmitter of the nonadrenergic noncholinergic inhibitory (iNANC) system, the only bronchorelaxant neural pathway of human airways. A number of studies also suggest that in some species epithelium‐derived NO accounts for the functional bronchoprotective role of the so‐called epithelium‐derived relaxing factor. In human airways, endogenous NO counteracts the bronchoconstriction induced by pharmacologic stimuli such as bradykinin, histamine, and methacholine. On the basis of these and other observations, it is suggested that a reduced synthesis and/or activity of endogenous NO may contribute to the pathogenesis of airway hyperresponsiveness that characterizes asthma and other respiratory disorders. This short paper summarizes the activities of endogenous NO in the airways of experimental animals and man, and discusses the evidence supporting the view that NO confers bronchoprotection.
Quantification and localisation of angiotensin II receptors and angiotensin converting enzyme in the developing rat heart
Authors: R. A Hunt, G. M Ciuffo, J. M Saavedra, D. C Tucker
Journal: Cardiovascular Research (1995)

Journal Article Quantification and localisation of angiotensin II receptors and angiotensin converting enzyme in the developing rat heart Get access Rachel A Hunt, Rachel A Hunt aDepartment of Psychology, University of Alabama at Birmingham, 218 Campbell Hall, Birmingham, AL 35294, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Gladys M Ciuffo, Gladys M Ciuffo bSection on Pharmacology, Laboratory of Clinical Sciences, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Juan M Saavedra, Juan M Saavedra bSection on Pharmacology, Laboratory of Clinical Sciences, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Diane C Tucker Diane C Tucker * aDepartment of Psychology, University of Alabama at Birmingham, 218 Campbell Hall, Birmingham, AL 35294, USA *Correspondence to Dr Tucker (Building 10, Room 2D-45). Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 6, June 1995, Pages 834–840, https://doi.org/10.1016/S0008-6363(96)88620-2 Published: 01 June 1995 Article history Received: 04 November 1994 Accepted: 23 January 1995 Published: 01 June 1995
Longitudinal Dissociation Within the Posterior AV Nodal Input of the Rabbit
Authors: Eugene Patterson, Benjamin J. Scherlag
Journal: Circulation (1999)

Background —Longitudinal dissociation of an anatomic pathway into 2 electrophysiologically distinct pathways has been hypothesized as a basis for localized AV nodal reentry and supraventricular arrhythmias. Methods and Results —Extracellular bipolar and intracellular microelectrodes were used to record activation in the superfused rabbit AV junction. A subset of rabbit hearts (n=19 of 72) demonstrated dissociation of the posterior AV nodal input into ≥2 functional pathways. Antegrade AH conduction was maintained by a pathway just inferior to the tendon of Todaro. Rate-dependent conduction block was observed in a second pathway just superior to the tricuspid annulus, allowing retrograde activation of the distal portion of the inferior posterior AV nodal input and leading to the formation of apparent “dead-end” pathways. The superior (antegrade) and inferior (retrograde) pathways were separated by a band of well-polarized but poorly excitable transitional cells. Additional decreases in the atrial cycle length progressively increased the AH interval, further delaying retrograde activation of the inferior pathway, and progressively moved the site of conduction block in the inferior pathway proximally, thus extending the length of the retrograde conduction pathway and allowing circus movement within the transitional cells of the posterior AV nodal connection. Conclusions —Longitudinal dissociation within the posterior AV nodal input can give rise to localized reentry and AV nodal reentrant tachycardia.
Investigation of Aortic Elastic Parameters [Aortic Distensibility and Aortic Strain] and Aorta Propagation Velocity in the Coronary Ectasia Patients with or without Critical Coronary Artery Disease
Authors: Edhem Deveci, Zekeriya Kaya, Özgür Günebakmaz, Yusuf Sezen, Asuman Biçer Yeşilay, Emre Erkuş, Halil İbrahim Altıparmak, Recep Demirbağ, Ali Yildiz
Journal: Journal of the American College of Cardiology (2013)
The Journal Itself.
Authors: Albert B. Hale
Journal: JAMA (1896)

Chicago, June 6, 1896. <h3>To the Editor:</h3> —In enclosing my vote, I take pleasure in asking to be allowed to thank you for your good work on ourJournal. I think it is<i>the</i>high-class weekly for the general profession in the United States. Cordially yours,
Health action zones set up
Authors: J. Warden
Journal: BMJ (1998)

Eleven health action zones are being set up in England as the Labour government's first attempt to break the link between poverty and ill health. The areas chosen have a total population of almost six million in some of the most deprived localities.

Although the funding of £5.3m ($8.5m) this year is less than £1 per head, a further £30m is pledged next year, when 10 or 12 more …
A PLEA FOR AN INSTITUTE OF HUMAN EMBRYOLOGY
Authors: FRANKLIN P. MALL
Journal: JAMA (1913)

A superficial glance at the facilities for the study of anatomy suggests that the great number of specialists and students of this subject should suffice to insure an effective organization of the forces to promote the science in a satisfactory way. In fact, the forces are well organized through well-equipped laboratories, national and international societies, well established journals and the very best year-books. All this is due to the popularity and usefulness of the science during many ages, but it is easy to discern that much is still needed before the newer science of anatomy can be cultivated more effectively. The parallel science of astronomy has in many respects a similar history to that of anatomy; it is also practical, popular and ancient; it has had its Hippocrates (Hipparchus), its Galen (Ptolemy) and its Vesalius (Copernicus); but its organization for research differs distinctly from that of anatomy. There are fewer