tbuckley/cabot-search huggingface dataset:
Inhibition of dipyridamole-induced ischemia by antianginal therapy in humans. Correlation with exercise electrocardiography.
Authors: F Lattanzi, E Picano, L Bolognese, C Piccinino, G Sarasso, A Orlandini, A L'Abbate
Journal: Circulation (1991)

BACKGROUND Dipyridamole echocardiography test (DET: two-dimensional echocardiographic monitoring with dipyridamole infusion up to 0.84 mg/kg in 10 minutes) is a useful tool for the noninvasive diagnosis of coronary artery disease. Aims of the present study were to assess the effects of antianginal drugs on dipyridamole-induced ischemia and to evaluate whether drug-induced changes in DET response may predict variations in exercise tolerance. METHODS AND RESULTS Fifty-seven patients with angiographically assessed significant coronary artery disease (greater than 70% lumen reduction in at least one major coronary vessel) performed a DET and an exercise electrocardiography test (EET) in random order both off treatment and on antianginal drugs (beta-blockers, calcium antagonists and nitrates, alone or in various combinations). The criterion for DET positivity was a transient dyssynergy of contraction absent or of a lesser degree in the baseline examination. In DET, two parameters were evaluated: the dipyridamole time (i.e., the time from onset of dipyridamole infusion to obvious dyssynergy) and the wall motion score index. DET sensitivity was 91% off therapy and fell to 65% under therapy (p less than 0.01). In the 37 patients who had a positive DET both off and on therapy, the dipyridamole time increased from 6 +/- 3 (off therapy) to 8 +/- 3 minutes (on therapy) (p less than 0.01). The wall motion score index at peak dipyridamole went from 1.38 +/- 0.14 to 1.31 +/- 0.14 (p less than 0.01). EET and DET yielded concordant (positive versus negative) results in 41 of 57 (71%) patients off and in 35 of 57 (61%) on therapy (p = NS). In the subgroup of 38 patients with both positive DET and EET without treatment, the therapy-induced variations in exercise time were significantly correlated with the variations in dipyridamole time (r = 0.5; p less than 0.01), not with variations in wall motion score index (r = 0.3; p = NS). CONCLUSIONS 1) Antianginal therapy can protect from dipyridamole-induced ischemia and 2) the therapy-induced changes in DET response parallel variations in exercise tolerance and might be useful for the objective, exercise-independent assessment of the therapy efficacy.
Assessment of iron stores in inflammation by assay of serum ferritin concentrations.
Authors: D R Blake, R F Waterworth, P A Bacon
Journal: BMJ (1981)

A serum ferritin concentration of below 15 microgram/l is accepted as indicating diminished iron reserves in an otherwise normal person. In patients with inflammatory disease this lower limit of normality may be inappropriate as inflammation may directly stimulate the production of ferritin protein. Results obtained in a survey of 150 patients with early inflammatory joint disease suggest that a ferritin concentration of 55 microgram/l is a more appropriate lower limit of normality.
Eating habits and attitudes among mothers of children with feeding disorders
Authors: A. Stein, J. Stein, E. A Walters, C. G Fairburn
Journal: BMJ (1995)

Feeding disturbances in young children are common.1 Furthermore, eating disorders are a substantial source of psychiatric morbidity among women of childbearing age.2 There has been no published research examining whether feeding disturbances of clinical severity in children are related to abnormal eating habits and attitudes among their mothers—though there is evidence that parents with eating disorders can adversely influence their young children's development, including feeding.3 If there were such a relation it would have important implications for the management of such children.

Over 12 months the mothers of all children with ICD-10 (International Classification of Diseases, 10th revision)4 diagnoses of a feeding disorder who were referred to local child psychiatric clinics covering one geographical area were identified (n=32). ICD-10 criteria require that a feeding disorder in infancy or …
18F-FDG PET/CT Findings of Obstructive Colitis Proximal to Colorectal Cancer
Authors: Jin Kyoung Oh, Hye Lim Park, Sonya Y. Park, Sung Hak Lee, Eun Ji Han, Yong An Chung, Sung Hoon Kim, Young Ha Park
Journal: Clinical Nuclear Medicine (2013)

This study was performed to determine the frequency and patterns of obstructive colitis (OC) seen on F-FDG PET/CT scan of patients with adenocarcinoma of the colon and rectum.Preoperative PET/CT scans and surgical records of 308 patients with surgically proven colorectal adenocarcinoma were retrospectively reviewed for the presence of colon obstruction and OC proximal to the colorectal adenocarcinoma. The distributions, patterns, and SUVmax of OC were evaluated on PET/CT. Abdominal CT, colonoscopic finding, and histopathologic findings of surgical specimen were also reviewed.Of 308 patients, PET/CT scans of 29 (9.4%) showed OC. The mean SUVmax of OC was 3.6 ± 2.2 (range, 1.6-12.3). Obstructive colitis was contiguous to the tumor in 23 patients (79.3%) and noncontiguous in 6 (20.7%). Obstructive colitis was diffuse in 25 patients (86%) and patchy in 4 (14%). It was segmental in 16 patients (55%) and pancolonic in 13 (45%). Twenty-three of 29 patients (79.3%) showed proximal wall thickening to colon cancer on abdominal CT performed about 3 days before PET/CT.The patients with OC on PET/CT was significantly associated with annular (P = 0.017), large-sized (P < 0.001), and advanced colon cancer (P < 0.001). However, there was no association between tumor size and SUVmax of OC.Ten proximal polyps were detected in 7 of 29 patients (24.1%) on colonoscopy and surgical specimen. Of these, 1 proximal polyp was removed before PET/CT scan, whereas the remaining 9 were not detected on PET/CT scan.Obstructive colitis is predominantly diffuse and contiguous with the obstructing adenocarcinoma. Colorectal cancer with OC tends to show annular shape and larger tumor size. Obstructive colitis may lower the possibility of detection of synchronous proximal colonic lesion by PET/CT.
Men who steal children.
Authors: P T d'Orban, P Haydn-Smith
Journal: BMJ (1985)

Le vol d'enfant est generalement considere comme etant le fait des femmes. Toutefois jusqu'a une date recente la plupart de ces delits etaient commis par des hommes et en Grande-Bretagne, de 1977 a 1982, les sexes furent en l'occurence egalement representes. L'hypothese etiologique de l'auteur est le motif sexuel
Reflections on the Education of the Psychiatrist
Authors: P.E. Sifneos
Journal: Psychotherapy and Psychosomatics (1967)

Research Articles| February 12 2010 Reflections on the Education of the Psychiatrist Subject Area: Psychiatry and Psychology P.E. Sifneos P.E. Sifneos Harvard Medical School, Massachusetts General Hospital Boston, Mass. USA Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1967) 15 (2-4): 260–272. https://doi.org/10.1159/000285895 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation P.E. Sifneos; Reflections on the Education of the Psychiatrist. Psychother Psychosom 31 December 1967; 15 (2-4): 260–272. https://doi.org/10.1159/000285895 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1967Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Short term effect of withdrawal of diuretic drugs prescribed for ankle oedema
Authors: J W de Jonge, J A Knottnerus, W M van Zutphen, G A de Bruijne, H A J Struijker-Boudier
Journal: BMJ (1994)

<h3>Abstract</h3> <b>Objective</b> : To determine the effect of withdrawing diuretic drugs on oedema in patients prescribed them for only ankle oedema, excluding patients with cardiac, hepatic, or renal failure. <b>Design</b> : Randomised controlled trial. <b>Setting</b> : 15 general practices in the Netherlands. <b>Patients</b> : 1202 patients aged 65 years or older and taking diuretic drugs, 63 of whom were eligible for the trial. <b>Main outcome measure</b> : Change in volumetrically determined ankle oedema (oedema index) over six weeks. <b>Results</b> : 34 patients were randomised to stop diuretics and 29 to the control group. In eight patients diuretics had to be restarted. Among patients who had diuretics withdrawn successfully, rebound oedema caused a temporary increase in mean oedema index. The peak level (3.5% (95% confidence interval 1.5% to 5.2%) was reached in the third week, after which the oedema seemed to be returning to the baseline level. <b>Conclusion</b> : Few patients who have been prescribed diuretics for only ankle oedema clearly have no contraindications to withdrawing diuretics. If patients are unlikely to have cardiac insufficiency and careful monitoring is provided, withdrawal of diuretics seems to be feasible, though moderate rebound oedema may occur for a short time.
Study of Ventricular Response in Atrial Fibrillation
Authors: LEO G. HORAN, JACK C. KISTLER
Journal: Circulation Research (1961)

A study was made of the variation in R-R interval in 47 long electrocardiographic recordings from 17 patients with atrial fibrillation. The distribution curve of ventricular intervals was found to vary in configuration according to the mean ventricular rate. A single high peak was seen at fast rates, two peaks at intermediate rates, and a single low peak flattening to a long low curve at slow rates.
Counting the Uninsured
Authors: Susan K. Reynolds
Journal: JAMA (1994)

<h3>To the Editor.</h3> —I read with great interest Dr Swartz's<sup>1</sup>article on the number of people without health insurance. I was glad to note that she did not assume that "no insurance" equals "no health care." However, I would like to inquire whether the figure of 58 million people who will be uninsured takes into account the possibility that these people will be eligible for benefits through the Veterans Affairs system, county and city health departments, automobile insurance (for accidents), workers' compensation, Medicaid after a spend-down period has occurred, charitable organizations such as the Shriners, the Lions Club, and the Junior League, Hill-Burton grants, residency program clinics, settlement-house— type programs, and, of course, uncompensated care given by physicians and hospitals. They may not be a fancy safety net, but if you are willing to accept long waits and drab waiting rooms, the public hospitals of this country can and
[35] LIVER TRANSPLANTATION (LT) FOR CHOLANGIO-CARCINOMA (CC): LONG-TERM RESULTS IN 42 PATIENTS
Authors: S. Dharancv, A. Louvet, M. Neau-Cransac, C. Meyer, C. Vanlemmens, A. Minello, J. Saric, P. Wolf, E. Boleslawski, P. Mathurin, F.R. Pruvot
Journal: Journal of Hepatology (2007)
918 PERISINUSOIDAL FIBROSIS IS ASSOCIATED WITH CHANGES IN SINUSOIDAL ENDOTHELIAL CELL (SEC) PHENOTYPE SUGGESTIVE OF A TRANSDIFFERENTIATION PROCESS
Authors: G. Borghi-Scoazec, S. Collardeau-Frachon, J. Dumortier, J.-Y. Scoazec
Journal: Journal of Hepatology (2010)
Contained Left Ventricular Free Wall Rupture After Myocardial Infarction
Authors: Paaladinesh Thavendiranathan, David Verhaert, Ayesha Hasan, Benjamin C. Sun, Chittoor Sai-Sudhakar, Sanjay Rajagopalan, Subha V. Raman
Journal: Journal of the American College of Cardiology (2010)
Deletion of the donor splice site of intron 4 in the glucokinase gene causes maturity-onset diabetes of the young.
Authors: F Sun, B Knebelmann, M E Pueyo, H Zouali, S Lesage, M Vaxillaire, P Passa, D Cohen, G Velho, C Antignac
Journal: Journal of Clinical Investigation (1993)

Missense and nonsense mutations in the glucokinase gene have recently been shown to result in maturity-onset diabetes of the young (MODY), a subtype of non-insulin-dependent diabetes mellitus with early age of onset. Glucokinase catalyzes the formation of glucose-6-phosphate and is involved in the regulation of insulin secretion and integration of hepatic intermediary metabolism. Nucleotide sequence analysis of exon 4 and its flanking intronic regions of the glucokinase gene, in four hyperglycemic individuals of a MODY family, revealed a deletion of 15 base pairs, which removed the t of the gt in the donor splice site of intron 4, and the following 14 base pairs. This deletion resulted in two aberrant transcripts, which were analyzed by reverse transcription of RNA from lymphoblastoid cells obtained from a diabetic patient. In one of the abnormal transcripts, exon 5 is missing, while in the other, the activation of a cryptic splice site leads to the removal of the last eight codons of exon 4. This intronic deletion in a donor splice site seems to cause a more severe form of glucose intolerance, compared with point mutations described in glucokinase. This might be due to a more pronounced effect on insulin secretion.
US doctors face curbs on referrals
Authors: D. Josefson
Journal: BMJ (2001)

Doctors may no longer refer Medicare patients to organisations in which they have a financial interest, according to new US Department of Health and Human Services regulations.

The department issued a new regulation that will bar physicians from referring Medicare patients to healthcare organisations, such as hospitals, radiology centres, physical and occupational therapy groups, as well as pharmacies and medical equipment suppliers, in which …
Bone-Marrow Transplantation in the Maroteaux–Lamy Syndrome (Mucopolysaccharidosis Type VI)
Authors: William Krivit, Mary Ella Pierpont, Kathleen Ayaz, Michael Tsai, Norma K.C. Ramsay, John H. Kersey, Sally Weisdorf, Richard Sibley, Dale Snover, Margaret M. McGovern, Marcia F. Schwartz, Robert J. Desnick
Journal: New England Journal of Medicine (1984)

A 13-year-old girl with the severe form of the Maroteaux-Lamy syndrome (mucopolysaccharidosis Type VI, arylsulfatase B deficiency) has had successful reconstitution with bone marrow from her HLA-MLC-matched sister who had normal arylsulfatase B activity. Full engraftment has been present for 24 months. The following biochemical and clinical changes have occurred: arylsulfatase B activity in peripheral lymphocytes and granulocytes increased to normal levels, and the activity in serial liver-biopsy specimens increased from about 3 per cent of the mean normal level 43 days after transplantation to about 16 per cent at 600 days. Urinary excretion of acid mucopolysaccharide decreased. Ultrastructural evidence of accumulated dermatan sulfate was no longer detectable in bone-marrow cells; in peripheral-blood lymphocytes, granulocytes, or platelets; or in Ito cells of liver. Twenty-four months after engraftment, hepatosplenomegaly was substantially decreased and cardiopulmonary function was normal. Visual acuity and joint mobility were also improved. The patient returned to school and continued to perform well in academic studies. Thus, bone-marrow transplantation provided a source of enzymatically normal cells, which have altered the metabolic and clinical course of the disease.
THE APPLICATION OF GA-67 IMAGING TO PLANNING OF RADIATION THERAPY FOR ESOPHAGEAL CARCINOMA
Authors: J F Montebello, M Fernandez-Ulloa, H R Elson, S J Lukes, B S Aron
Journal: Clinical Nuclear Medicine (1981)

Montebello, J F; Fernandez-Ulloa, M; Elson, H R; Lukes, S J; Aron, B S Author Information
Hydrochlorothiazide Effects on Serum Calcium and Immunoreactive Parathyroid Hormone Concentrations
Authors: ROBERT M. STOTE
Journal: Annals of Internal Medicine (1972)

Nine normal subjects were given 50 mg of hydrochlorothiazide twice daily for 25 days, to investigate the relationships between circulating immunoreactive parathyroid hormone (iPTH) and changes in calcium homeostasis induced by this diuretic. Total and ionized plasma calcium concentrations were significantly increased during administration of hydrochlorothiazide and for at least 2 weeks after withdrawal of the drug. There was no clearly definable effect either on protein binding of calcium or on iPTH. The normal negative correlation between ionized calcium and iPTH appeared to remain intact, and the mechanism of the increase in serum calcium is yet to be elucidated.
Value of laparoscopy in the diagnosis and management of pancreatic carcinoma.
Authors: A Cuschieri, A W Hall, J Clark
Journal: Gut (1978)

Our experience with laparoscopy in the diagnosis and staging of 23 cases of pancreatic cancer is reported. This endoscopic procedure has proved useful in the diagnosis of the disease, in the assessment of operability, and in the retrieval of material for histological and cytological confirmation of pancreatic cancer. An infra-gastric laparoscopic method for inspection of the body and tail of the pancreas is described and the technique may allow the earlier detection of neoplasms in this region.
Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles
Authors: Robert Flaumenhaft, James R. Dilks, Jennifer Richardson, Eva Alden, Sunita R. Patel-Hett, Elisabeth Battinelli, Giannoula L. Klement, Martha Sola-Visner, Joseph E. Italiano
Journal: Blood (2008)
568. Ex Vivo Mesenchymal Stem Cell Therapy with rAAV2 Encoding BMP-2 Enhances Bone Regeneration in Ovariectomized Mouse Model
Authors: Sanjay Kumar, Tim R. Nagy, Selvarangan Ponnazhagan
Journal: Molecular Therapy (2006)

Mesenchymal stem cells (MSC) represent an ideal source for ex- vivo therapy for treatment of genetic, age-related, and segmental bone defects to increase bone mass. Recent studies have demonstrated that pluripotent MSC can home to the bone marrow and participate in new bone formation, raising the possibility that MSC-based therapies may be developed for effective intervention of bone loss. The pluripotent property of MSC necessitates selection of lineage- specific cells or restricted expression of therapeutic genes into committed progenitors with specific phenotypes for regulated gene therapy. An ideal approach to utilize them is by ex vivo gene therapy for osteopenia by modulating the MSC to function as a continuous source for providing progeny osteoblasts by retaining the capacity of self-renewal and direct the differentiated early progenitors towards osteoblast lineage, which would enhance new bone formation. Our earlier studies indicated efficient transduction of MSC by rAAV2. In the present study, we determined the efficacy of MSC transduced by rAAV-bone morphogenetic protein-2 (BMP-2) to repopulate and enhance bone density in a mouse model of osteoporosis. Low- passage MSC were transduced ex vivo with rAAV2 encoding BMP-2 under the transcriptional control of collagen type 1a promoter. Following rAAV transduction, the cells were maintained in culture for 10 days without induction of differentiation by maintaining the culture with FGF2. Approximately 107 MSC were then injected to ovariectomized female C57BL/6 mice intravenously. Prior to the injections, the cells were transfected with a plasmid encoding murine a4 integrin for bone-specific homing. Groups of mice also received rAAV2-GFP transduced MSC ectopically expressing α4 integrin or unmodified MSC. Dual Energy X-ray absorptiometry (DEXA) analysis was performed on all the animals prior to MSC injection and periodically after the treatments. Results indicated that the group of mice transplanted with MSC expressing BMP-2 showed statistically significant (p<0.035) increase in the bone mineral density (BMD) values compared to the rAAV2-GFP transduced MSC or unmodified MSC transplanted groups. Cohorts of mice from each group were sacrificed after 5 weeks and 10 weeks for bone histomorphometry, osteoclast/osteoblast ratio and the identification of engrafted MSC. Histomorphometric analysis using trichrome stain also confirmed the DEXA data where more osteoblasts and less osteoclasts were seen in the trabecular and growth plate area ofthe bone in BMP-2 treated group compared to controls. The long term effects of this ex vivo therapy on BMD will be discussed.
Respiratory Distress Syndrome in the Adult After Cardiopulmonary Bypass
Authors: Roberto Llamas
Journal: JAMA (1973)

Fifteen episodes of the adult respiratory distress syndrome occurred in 14 patients after cardiopulmonary bypass. The clinical course was characterized by tachypnea, hyperventilation, and progressive hypoxemia developing postoperatively after a symptom-free period. Recovery occurred after institution of respiratory support and administration of steroids, diuretics, and antibiotics. There were no deaths. Prolonged cardiopulmonary bypass time, a history of heavy cigarette smoking, and a tendency to develop cardiocirculatory failure postoperatively was present more frequently in these patients as compared to a control group of ten who experienced an uneventful recovery. Early recognition of the adult respiratory distress syndrome by serial monitoring of arterial blood gases and aggressive management of hypoxemia and bronchopulmonary infections are thought to be important factors in survival.
Updates from the British Association of Dermatologists 85th annual meeting, 5-8 July 2005, Glasgow, U.K.
Authors: D.J. Eedy, J.S.C. English, I.H. Coulson
Journal: British Journal of Dermatology (2006)

The conference highlighted the progress made in understanding recent biological, epidemiological and therapeutic advances in dermatology. Here we provide a synopsis of the main research and clinical findings presented at the meeting of the British Association of Dermatologists (BAD) held during 5-8 July 2005, in Glasgow, U.K., drawing attention to the most important advances and summaries. The BAD meeting was held at the Scottish Exhibition and Conference Centre, Glasgow (Fig. 1). The annual dinner was held in the wonderful setting of Stirling Castle, with Dr Robin Graham-Brown as host.