Treatment for Histiocytic Lymphoma
Authors: STUART A. GROSSMAN
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 October 1980Treatment for Histiocytic LymphomaSTUART A. GROSSMAN, M.D.STUART A. GROSSMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-4-640_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article by Sweet and colleagues in the June issue (1) suggests that cyclophosphamide, vincristine, methotrexate with leucovorin rescue, and cytarabine (COMLA) should be considered "as an initial form of therapy in previously untreated patients with advanced diffuse histiocytic lymphoma." The authors state that the major advantages of this regimen are avoidance of the potential toxicities of bleomycin, doxorubicin, and prednisone and provision of some degree of protection from central nervous system relapse. These are not major advantages and are more than offset by disadvantages of this treatment regimen.Both bleomycin and doxorubicin can be avoided in...References1. SWEET D, GOLOMB H, and ULTMANN J. Cyclophosphamide, vincristine, methotrexate with leucovorin rescue, and cytarabine (COMLA) combination sequential chemotherapy for advanced diffuse histiocytic lymphoma. Ann Intern Med. 1980;92:785-90. LinkGoogle Scholar2. JOHNSON G, COSTELLO W, and OKEN M. The value of adriamycin and mid-cycle treatment in multidrug therapy of non-Hodgkin's lymphoma. Proc Am Assoc Cancer Res-Am Soc Clin Oncol. 1979;21:196. Abstract. Google Scholar3. YOUNG R, HOWSER D, ANDERSON T, FISHER R, and DEVITA V. Central nervous system complications of non-Hodgkin's lymphoma. Am J Med. 1979;66:635-43. CrossrefGoogle Scholar1. SWEET D, GOLOMB H, and ULTMANN J. Cyclophosphamide, vincristine, methotrexate with leucovorin rescue, and cytarabine (COMLA) combination sequential chemotherapy for advanced diffuse histiocytic lymphoma. Ann Intern Med. 1980;92:785-90. LinkGoogle Scholar2. MCKELVEY E, GOTTLIEB J, and WILSON H. Hydroxyldaunomycin (adriamycin) combination chemotherapy in malignant lymphoma. Cancer. 1976;38:1484-93. CrossrefMedlineGoogle Scholar3. MCKELVEY E. Review of CHOP-HOP combination chemotherapy in malignant lymphoma. Proc Am Soc Clin Oncol. 1978;19:415. Abstract. Google Scholar4. BUNN P, SCHEIN P, BANKS P, and DEVITA V. Central nervous system complications in patients with diffuse histiocytic and undifferentiated lymphoma: leukemia revisited. Blood. 1976;47:3-10. CrossrefMedlineGoogle Scholar5. SKARIN A, ROSENTHAL D, MOLONEY W, and FREI E. Combination chemotherapy of advanced non-Hodgkin lymphoma with bleomycin, adriamycin, cyclophosphamide, vincristine, and prednisone (BACOP). Blood. 1977;49:759-70. MedlineGoogle Scholar1. MCKELVEY E, GOTTLIEB J, and WILSON H. Hydroxyldaunomycin (adriamycin) combination chemotherapy in malignant lymphoma. Cancer. 1976;38:1484-93. CrossrefMedlineGoogle Scholar2. YOUNG R, HOWSER D, and ANDERSON T. Central nervous system complications of non-Hodgkin's lymphoma. Am J Med. 1979;66:435-43. CrossrefMedlineGoogle Scholar3. HERMAN T, HAMMOND N, JONES S, BUTLER J, and MCKELVEY E. Involvement of the central nervous system by non-Hodgkin's lymphoma. Cancer. 1979;43:390-7. CrossrefMedlineGoogle Scholar4. SKARIN A, CANELLOS G, and ROSENTHAL D. Therapy of diffuse histiocytic (DH) and undifferentiated (DU) lymphoma with high-dose methotrexate and citrovorum factor rescue (MTX/CF), bleomycin (B), adriamycin (A), cyclophosphamide (C), oncovin® (O) and decadron (D) (MBACOD). Proc Am Assoc Cancer Res-Am Soc Clin Oncol. 1980;21:463. Abstract. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STUART A. GROSSMAN, M.D.Affiliations: The Johns Hopkins Oncology Center Baltimore, MD 21205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1980Volume 93, Issue 4Page: 640-642KeywordsCentral nervous systemCyclophosphamideDiffuse large B-cell lymphomaMethotrexateToxicity ePublished: 1 December 2008 Issue Published: 1 October 1980 PDF downloadLoading ...