tbuckley/cabot-search huggingface dataset:
Positive Antinuclear Factor in Patients with Unexplained Pulmonary Fibrosis
Authors: HIROSHI NAGAYA
Journal: Annals of Internal Medicine (1969)

Twenty patients with unexplained pulmonary fibrosis and circulating antinuclear factor were identified. Diseases commonly associated with antinuclear factor, such as systemic lupus erythematosus or scleroderma, were excluded. Half of the patients showed typical restrictive ventilatory defects and X-ray evidence of severe fibrotic changes. The remaining patients predominantly had evidence of obstructive airway diseases. Four lung biopsies were available. Three showed histological evidence of interstitial pulmonary fibrosis. Immunofluorescent study of one of the biopsy sections with pulmonary fibrosis from a patient with only IgM serum antinuclear factor showed IgM in the alveolar septa. Relatively little fibrosis was present in immunoglobulin-laden areas whereas no immunoglobulin could be demonstrated in the adjacent alveolar septa showing marked fibrosis. Seven out of 10 patients with X-ray evidence of severe interstitial pulmonary fibrosis and typical restrictive ventilatory defects had only IgM antinuclear factor in their sera. Altered immunologic reactions associated with the generation of autoantibody may play a role in the pathogenesis of interstitial pulmonary fibrosis.
STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis
Authors: Mark H. Kaplan, Nicole L. Glosson, Gretta L. Stritesky, Norman Yeh, John Kinzfogl, Sara L. Rohrabaugh, Ritobrata Goswami, Duy Pham, David E. Levy, Randy R. Brutkiewicz, Janice S. Blum, Scott Cooper, Giao Hangoc, Hal E. Broxmeyer
Journal: Blood (2011)
Double-Blind, Placebo-Controlled, Randomized Phase 2 Study of the Proapoptotic Agent AT-101 Plus Docetaxel, in Second-Line Non-small Cell Lung Cancer
Authors: Neal Ready, Nina A. Karaseva, Sergey V. Orlov, Alexander V. Luft, Olexandr Popovych, Jon T. Holmlund, Brian A. Wood, Lance Leopold
Journal: Journal of Thoracic Oncology (2011)
Attitudes Toward Women Physicians in Medical Academia
Authors: Arlene Scadron, Marlys H. Witte, Morris Axelrod, Edward A. Greenberg, Cynthia Arem, June E. G. Meitz
Journal: JAMA (1982)

To determine attitudes toward women physicians within medical academia, we administered a survey to a probability sample of male and female senior medical students, faculty, and top-level administrators in a randomized, stratified subset of ten medical schools. Of the 984 respondents (65% response rate), men were much less supportive overall than women of female leaders. While women strongly disagreed with the idea that women physicians who spend long hours at work neglect home and family, men were almost equally divided on this issue. Each group rated the "typical" faculty member as "strong, fair, and progressive," but male faculty also were characterized as "egotistical" while female faculty were rated more "sensitive and altruistic." Male students were least likely to support a search for a female dean, hiring more female faculty members, or accepting an incoming class in which the majority were women.
CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses
Authors: Rosa Varona, Ricardo Villares, Laura Carramolino, Íñigo Goya, Ángel Zaballos, Julio Gutiérrez, Miguel Torres, Carlos Martínez-A., Gabriel Márquez
Journal: Journal of Clinical Investigation (2001)

CCR6 expression in dendritic, T, and B cells suggests that this β-chemokine receptor may regulate the migration and recruitment of antigen-presenting and immunocompetent cells during inflammatory and immunological responses. Here we demonstrate that CCR6–/– mice have underdeveloped Peyer’s patches, in which the myeloid CD11b+ CD11c+ dendritic-cell subset is not present in the subepithelial dome. CCR6–/– mice also have increased numbers in T-cell subpopulations within the intestinal mucosa. In 2,4-dinitrofluorobenzene–induced contact hypersensitivity (CHS) studies, CCR6–/– mice developed more severe and more persistent inflammation than wild-type (WT) animals. Conversely, in a delayed-type hypersensitivity (DTH) model induced with allogeneic splenocytes, CCR6–/– mice developed no inflammatory response. The altered responses seen in the CHS and DTH assays suggest the existence of a defect in the activation and/or migration of the CD4+ T-cell subsets that downregulate or elicit the inflammation response, respectively. These findings underscore the role of CCR6 in cutaneous and intestinal immunity and the utility of CCR6–/– mice as a model to study pathologies in these tissues.
US buyers of drugs from Canadian pharmacies face prosecution
Authors: D. Spurgeon
Journal: BMJ (2003)

The US Food and Drug Administration has threatened to take legal action to prevent the import of cheap prescription drugs from Canada and other countries, says a report in the New York Times . Online Canadian pharmacies are popular with Americans, because price regulation in Canada means that drugs there are much cheaper than in the United States.

The report said that William Hubbard, associate commissioner of the FDA, had written to a lawyer in New Orleans who had asked about federal policy, saying importation could be illegal (13 March, sect C: 2; www.nytimes.com). The letter said, “Those who aid and abet a criminal violation …
Prescription for "Sore Throat"
Authors: Harry A. Tubbs
Journal: JAMA (1974)

<h3>To the Editor.—</h3> A frequently encountered question asked by medical student preceptees and physicians new to the private clinical practice of medicine is: "Which patient with a sore throat should be treated with antibiotics and why?" We believe that type A β-streptococci should be identified or eliminated in the diagnosis of any acute sore throat by culture, and we agree that office nurses can do this effectively, provided that the technician can report β-hemolysis inhibited by bacitracin, and morphological identification of streptococci from stained smears from the hemolytic colonies. To depend on hemolysis alone is very precarious. Anyone who has a really<i>sore</i>throat should have a pharyngeal culture taken. Even in infectious mononucleosis, up to 25% superinfection by hemolytic streptococci has been reported. Our office nurses could prescribe an effective antibiotic for an appropriate period of time if they were called upon to do so in most cases. But
Fetal hemoglobin expression in the compound heterozygous state for ?117 (G?A)A? HPFH and IVSII-745 (C?G) ?+ thalassemia: A case study
Authors: George V.Z. Dedoussis, Klio Sinopoulou, Marilena Gyparaki, Aphroditi Loutradis
Journal: American Journal of Hematology (1999)

We studied a family in which two inherited defects of the non-α-globin cluster segregate: Greek hereditary persistence of fetal hemoglobin (HPFH) and β-thalassemia. The compound heterozygote is a healthy man with 43% HbF, Gγ/Aγ ratio (27:73) differing from that of 10 simple heterozygotes for the Greek HPFH (92:8), normal levels of total Hb (13.3 g/dl), and reduced HbA2 levels comparing with the levels of β-thal heterozygotes for the same mutation. Molecular analysis of the β-globin genotype revealed the presence of the IVSII-745 (C→G) β+ RNA splice mutation in trans with the −117 G→A Greek HPFH. The β+ mutation was linked to haplotype VII and the Greek HPFH was associated with haplotype Ia. The father of the compound heterozygote carries the Greek HPFH in trans with the −158 C→T on the Gγ promoter, which is linked with haplotype IV. He presented 13.5% HbF with a Gγ/Aγ ratio 75:25. His daughter was a compound heterozygote for the IVSII-745 mutation in trans with the −158 C→T, while her HbF levels were 3.7% with a Gγ/Aγ ratio 31:69. Am. J. Hematol. 61:139–143, 1999. © 1999 Wiley-Liss, Inc.
CATION EXCHANGE RESINS AS AN ADJUNCT IN TREATMENT OF HEART FAILURE
Authors: J. Edwin Wood
Journal: JAMA (1952)

Restriction of sodium in the diet has been accepted as helpful in the management of many patients with congestive heart failure and certain patients with other forms of edema, but the ideal sodium intake cannot always be accomplished by diet alone. In 1946, Dock<sup>1</sup>suggested that a cation resin could be used to remove sodium, potassium, calcium, and magnesium from ingested foods and further indicated that such a resin was nontoxic for dogs and rats. Extensive studies in animals<sup>2</sup>have demonstrated further the absence of toxicity from cation resins over short and long periods. These observers find that prolonged administration of the ammonium form of resin has not interfered with health, nutrition, or hematological development of animals. A detailed review<sup>3</sup>of the literature on ion exchange resins and edema discusses fully the rationale for the use of these substances. A cation exchange resin can also restrict the absorption of sodium from the human intestine,<sup>4</sup>and its use has been found practical and effective in man.<sup>4b,d</sup>The
Antivenin Information and Deposition Centers
Authors: S. J. Rao
Journal: JAMA (1970)

To the Editor:—  Bites by imported venomous snakes are not uncommon in the United States. Russell 1 notes 19 such cases at the Los Angeles County, University of Southern California Medical Center (including one by the puff adder) during the past 12 years. The puff adder noted by Takahashi and Tu ( 211 :1857, 1970) indicates once again the need to acquaint physicians on the deposition and disposition of antivenins for bites by exotic snakes in the United States.  It would not be practical, nor is it necessary, to establish a central antivenin deposit for antiserum as suggested by these authors. The listing of available antivenin is a service already provided by the American Association of Zoological Parks and Aquariums. This group compiles and distributes an accurate listing of all snake antivenins available at zoos and many other facilities throughout the United States. A call to almost any zoo, or at
Drugs in sport: the pressure to perform
Authors: C Jarvis
Journal: British Journal of Sports Medicine (2004)

British Medical Association, London: BMJ Books, 2002, £15.95, pp 192, paperback. ISBN 0727916068

The book was launched in association with an excellent one day conference held in London in 2002 and attended by the reviewer. It was researched and published before the publication of the IOC study detailing widespread problems with unlisted banned substances in supplements and undoubtedly the authors will mention this in any future edition. Not all the authors’ names will be familiar to British sports physicians, and some reference to their …
SERIAL OPTICAL CONHERENCE TOMOGRAPHY FINDINGS FROM 6 TO 12 MONTHS AFTER IMPLANTATION OF ZILVER PTX STENTS FOR THE FEMOROPOPLITEAL LESIONS
Authors: Tomoi Yusuke, Yoshimitsu Soga, Shoichi Kuramitsu, Hideaki Aihara, Kenji Ando
Journal: Journal of the American College of Cardiology (2014)
PMO-093 MRNA profiling of the cancer degradome in oesophago-gastric adenocarcinoma
Authors: J P Baren, G D Stewart, A Stokes, K Gray, C J Pennington, C Deans, S Paterson-Brown, A C Riddick, D R Edwards, K C Fearon, J A Ross, R J Skipworth
Journal: Gut (2012)

<h3>Introduction</h3> Degradation of the extracellular matrix is fundamental to tumour development, invasion and metastasis. Several protease families have been implicated in the development of a broad range of tumour types, including oesophago-gastric (OG) adenocarcinoma. The aim of this study was to analyse expression levels of all core members of the cancer degradome in OG adenocarcinoma, and to investigate the relationship between expression levels and tumour/patient variables associated with poor prognosis. <h3>Methods</h3> Comprehensive expression profiling of the protease families [matrix metalloproteinases (MMPs), members of the ADAM metalloproteinase-disintegrin family (ADAMs)], their inhibitors [tissue inhibitors of metalloproteinase (TIMPs)], and molecules involved in the c-Met signalling pathway, was performed using quantitative real-time reverse transcription PCR in a cohort of matched malignant and benign peri-tumoural OG tissue (n=25 patients). Data were analysed with respect to clinico-pathological variables (tumour stage and grade, age, sex and pre-operative plasma C-reactive protein level). <h3>Results</h3> Gene expression of MMP1, 3, 7, 9, 10, 11, 12, 16 and 24 was upregulated by factors greater than fourfold in OG adenocarcinoma samples compared with matched benign tissue (p&lt;0.01). Expression of ADAM8 and ADAM15 correlated significantly with tumour stage (p=0.048 and p=0.044), and ADAM12 expression correlated with tumour grade (p=0.011). <h3>Conclusion</h3> This study represents the first comprehensive quantitative analysis of the expression of proteases and their inhibitors in human OG adenocarcinoma. These findings implicate elevated ADAM8, 12 and 15 mRNA expression as potential prognostic molecular markers. <h3>Competing interests</h3> None declared.
An interdisciplinary approach to brain evolution: A long due debate
Authors: Francisco Aboitiz, Daniver Morales, Juan Montiel
Journal: Behavioral and Brain Sciences (2003)

A dorsalization mechanism is a good candidate for the evolutionary origin of the isocortex, producing a radial and tangential expansion of the dorsal pallium (and perhaps other structures that acquired a cortical phenotype). Evidence suggests that a large part of the dorsal ventricular ridge (DVR) of reptiles and birds derives from the embryonic ventral pallium, whereas the isocortex possibly derives mostly from the dorsal pallium. In early mammals, the development of olfactory-hippocampal associative networks may have been pivotal in facilitating the selection of a larger and more complex dorsal pallium which received both collothalamic and lemnothalamic sensory information. Finally, although it is not clear exactly when mammalian brain expansion began, fossil evidence indicates that this was a late event in mammaliaform evolution.
Antianginal and Antiischemic Effects of Ivabradine, an I <sub>f</sub> Inhibitor, in Stable Angina
Authors: Jeffrey S. Borer, Kim Fox, Patrice Jaillon, Guy Lerebours
Journal: Circulation (2003)

Background— Heart rate reduction should benefit patients with chronic stable angina by improving myocardial perfusion and reducing myocardial oxygen demand. This study evaluated the antianginal and antiischemic effects of ivabradine, a new heart rate–lowering agent that acts specifically on the sinoatrial node. Methods and Results— In a double-blind, placebo-controlled trial, 360 patients with a ≥3-month history of chronic stable angina were randomly assigned to receive ivabradine (2.5, 5, or 10 mg BID) or placebo for 2 weeks, followed by an open-label 2- or 3-month extension on ivabradine (10 mg BID) and a 1-week randomized withdrawal to ivabradine (10 mg BID) or placebo. Primary efficacy criteria were changes in time to 1-mm ST-segment depression and time to limiting angina during bicycle exercise (exercise tolerance tests), performed at trough of drug activity. In the per-protocol population (n=257), time to 1-mm ST-segment depression increased in the 5 and 10 mg BID groups ( P &lt;0.005); time to limiting angina increased in the 10 mg BID group ( P &lt;0.05). Deterioration in all exercise tolerance test parameters occurred in patients who received placebo during randomized withdrawal (all P &lt;0.02) but not in those still receiving ivabradine. No rebound phenomena were observed on treatment cessation. Conclusions— Ivabradine produces dose-dependent improvements in exercise tolerance and time to development of ischemia during exercise. These results suggest that ivabradine, representing a novel class of antianginal drugs, is effective and safe during 3 months of use; longer-term safety requires additional assessment.
Maternal Antibodies, Childhood Infections, and Autoimmune Diseases
Authors: Rolf M. Zinkernagel
Journal: New England Journal of Medicine (2001)

With this article by Nobel laureate Rolf Zinkernagel, the Immunology series that began in July 2000 comes to an end. Zinkernagel's thesis concerns the influence of a mother's immunologic memory on the effectiveness of childhood vaccination and the susceptibility of her child to infectious diseases. He reviews how immunity in the entire community (herd immunity) affects immune protection not only in the mother but also in succeeding generations. Zinkernagel warns that lax vaccination programs and complacency produced by improved living standards will have global effects on susceptibility to infection and autoimmune diseases.
A Five-Amino-Acid Peptide Blocks Met- and Ron-Dependent Cell Migration
Authors: Alexandra Matzke, Peter Herrlich, Helmut Ponta, Véronique Orian-Rousseau
Journal: Cancer Research (2005)

Abstract Various human cancers express elevated levels of the receptor tyrosine kinases Met or Ron and v6-containing isoforms of CD44. The activation of Met and Ron requires the presence of such CD44 v6-containing isoforms that act as coreceptors. Three amino acids within the v6 sequence were identified by mutational analysis to be essential for the coreceptor function: EWQ in the rat sequence and RWH in human. Peptides comprising these three amino acids (the smallest containing only five amino acids) efficiently act as competitors and block ligand-dependent activation of Met or Ron and subsequent cell migration.
Intermittent cyclophosphamide in refractory rheumatoid arthritis.
Authors: K Horslev-Petersen, J M Beyer, P Helin
Journal: BMJ (1983)

Three patients with refractory rheumatoid arthritis were treated with oral cyclophosphamide; in two cases this was supplemented with pulse treatment with methylprednisolone. Long term remission was induced in all three patients and was sustained until follow up at least nine months after the methylprednisolone was stopped. Leucopenia occurred but resolved when cyclophosphamide was reduced from daily to intermittent dosing. Intermittent treatment with cyclophosphamide, possibly in conjunction with pulses of methylprednisolone, may induce remission in patients with rheumatoid arthritis refractory to other forms of treatment.
Senators Request Data About “Pay-for-Delay”
Authors: Rita Rubin
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rhinasthma: a new specific QoL questionnaire for patients with rhinitis and asthma
Authors: I. Baiardini, M. Pasquali, A. Giardini, C. Specchia, G. Passalacqua, S. Venturi, F. Braido, S. Bonini, G. Majani, G. W. Canonica
Journal: Allergy (2003)

Introduction: To date we have available specific instruments assessing health‐related quality of life (HRQL) in rhinoconjunctivitis or in asthma, but not instruments evaluating rhinitis and asthma together, although they often coexist. The aim of our study was to develop and validate a specific quality of life (QoL) questionnaire for adult patients with rhinoconjunctivitis, asthma or both. Materials and methods: A pool of 42 items covering the main symptoms and problems related to respiratory allergy, was generated based on literature review and clinical experience. The items were randomly listed and presented to 148 consecutive outpatients 46 suffering from asthma (age 32.9 ± 14.3 years), 53 suffering from rhinoconjunctivitis (age 32.6 ± 11.5 years) and 49 from asthma and rhinoconjunctivitis (age 35.6 ± 12.2 years). The patients were asked to indicate which item they had directly experienced and for each of them, its importance on a four‐point scale (1 = not important; 4 = very important). Twelve items were cancelled from the list, because of low importance or redundance. In the instrument validation phase, 104 patients (42 with rhinoconjunctivitis alone and 62 with asthma and rhinoconjunctivitis) were evaluated with the generic instrument SF‐36 and the new questionnaire (RHINASTHMA). Results: RHINASTHMA was able to differentiate patients with rhinitis from those with both rhinitis and asthma. In stable condition, RHINASTHMA showed good reliability. The factor analysis extracted three factors with a good reliability (0.93, 0.87, 0.76). Discussion: RHINASTHMA is the first tool aimed at evaluating HRQL impairment in patients with rhinitis and/or asthma. It provides a short and simple assessment, and has overall psychometric properties. This is of relevance because of the frequent asthma–rhinitis comorbidity.
Vaccination in Infancy with Oral Poliomyelitis Vaccine and Diphtheria, Tetanus, Pertussis Vaccine
Authors: P. F. Benson, N. R. Butler, J. M. Costello, J. Urquhart, M. Barr, A. P. Goffe, G. J. Knight, T. M. Pollock
Journal: BMJ (1963)

conducting tissue or to a transient disturbance in a healthy heart.Many others have contributed to our experience of resuscitation and we are grateful to them and also to Dr. D. D. C.
Colleges Recognized by the Illinois State Board of Health.
Authors: J. A. Egan
Journal: JAMA (1897)

Springfield, Nov. 27, 1897. <h3>To the Editor:</h3> —The list of medical colleges recognized by the Illinois State Board of Health, published in theJournalof the 27th inst., was made out in this office last September, and received my sanction after a hurried examination just prior to my leaving the office for several days. On returning I found that many errors had been made, so the lists distributed were at once recalled, and on October 1 a corrected list was sent out with the statement that it took the place of that issued in September, a copy of which you published. This Board does not permit colleges which are recognized as in "good standing" to accord advanced standing to students from non-recognized or partially recognized colleges, without full examination.