tbuckley/cabot-search huggingface dataset:
Progress Treating Childhood Diseases Creates Challenges in Adult Care
Authors: Aaron Levin
Journal: Annals of Internal Medicine (1998)

Currents15 May 1998Progress Treating Childhood Diseases Creates Challenges in Adult CareAaron LevinAaron LevinSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-10-199805150-00038 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Childhood leukemia survivor Thaddeus Leaseburg of Houston balances study at Baylor College of Medicine with energetic-some might say risky-recreation: motorcycle riding, scuba diving, and flying an airplane. A few decades ago, children like Leaseburg who had cancer, congenital heart disease, or metabolic disturbances were not expected to live beyond childhood. Today, children who have these diseases are surviving well into adulthood. For instance, the median survival time of a child with cystic fibrosis, which at one time was measured in months, is now 31 years.However, the benefits of medical success are accompanied by often-asymptomatic conditions-echoes of both the childhood ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1998Volume 128, Issue 10Page: 882-884KeywordsCancer chemotherapyCancer treatmentChildrenCongenital heart defectsCongenital heart diseaseCystic fibrosisDietDown syndromeMenarchePregnancy Issue Published: 15 May 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Effectiveness of quality improvement initiative (Guidelines Applied to Practice [GAP] project) in improving the care of medicare patients and women with acute myocardial infarction
Authors: Raiendra H. Mehta, Cecelia K. Montoye, Meg Gallogly, Patricia Baker, Angela Blount, Steven Borzak, Eva Kline-Rogers, Thomas LaLonde, Michele Orza, Robert Parrish, Stuart Winston, Arthur A. Riba, Kim A. Eagle
Journal: Journal of the American College of Cardiology (2002)
Superselective transarterial chemoembolization for hepatocellular carcinoma. Validation of treatment algorithm proposed by Japanese guidelines
Authors: Kenichi Takayasu, Shigeki Arii, Masatoshi Kudo, Takafumi Ichida, Osamu Matsui, Namiki Izumi, Yutaka Matsuyama, Michiie Sakamoto, Osamu Nakashima, Yonson Ku, Norihiro Kokudo, Masatoshi Makuuchi
Journal: Journal of Hepatology (2011)
DEAD TEETH IN THE JAWS.
Authors: Truman W. Brophy
Journal: JAMA (1885)

<h3>To the Editor of The Journal of the American Medical Association.</h3> —<i>Sir: The Medical Record</i>of November 8th contains a reply from Dr. Samuel Sexton to gentlemen who have criticised, in the columns of that journal, his previous article on "Dead Teeth in the Jaws"; and I beg space to present some views on this long neglected, but very important subject of lesions of the dental organs. If, by means of this discussion, members of the profession are brought to more fully realize the value of faithfully bestowing upon the teeth the care essential to their preservation—of adopting proper hygienic measures to this end, and of appreciating the difference between the scientific treatment of dental diseases and the treatment too often resorted to by uneducated dentists, the laity as well as the profession at large will be greatly benefited thereby. Dr. Sexton says: "The retention in the jaws of
Sensors: Optical Nanosphere Sensor Based on Shell‐By‐Shell Fabrication for Removal of Toxic Metals from Human Blood (Adv. Healthcare Mater. 6/2013)
Authors: S. A. El‐Safty, S. Abdellatef, M. Ismael, A. Shahat
Journal: Advanced Healthcare Materials (2013)

Sherif El-Safty and co-workers report on page 854 a novel, pH-dependent sensor design based on naked-eye detection for the removal of toxic metal ions from drinking water and human blood. The inexpensive, simple-to-use, and multi-ion sensing design shows efficient reproducibility, longevity, selectivity, and signal stability. This unique hierarchical sensor has potential for the rapid screening of blood lead levels so that the effects of lead toxicity can be avoided.
US prisoner at centre of heart transplant row
Authors: D. Josefson
Journal: BMJ (2002)

A Californian man has become the first prison inmate in the United States to receive a heart transplant, sparking a debate over the allocation of organs.

The case received widespread media attention, both because the patient's status as a prisoner made him eligible to go on the transplant waiting list and because the transplantation itself and the before and after medical care were funded by the taxpayer.

To qualify for a transplant, patients in the United States must first show their ability to pay for the procedure or have …
Omega-3 Fatty Acid Prevents Heart Rate Variability Reductions Associated with Particulate Matter
Authors: Isabelle Romieu, Martha Maria Téllez-Rojo, Mariana Lazo, Abigail Manzano-Patiño, Marlene Cortez-Lugo, Pierre Julien, Marie Claire Bélanger, Mauricio Hernandez-Avila, Fernando Holguin
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Context: Environmental exposure to particulate matter of 2.5 μm or less (PM2.5) has been associated with changes in heart rate variability (HRV).Objective: To evaluate the effect of supplementation with omega-3 polyunsaturated fatty acids on the reduction of HRV associated with PM2.5 exposure.Design: Randomized double-blind trial.Setting: Mexico City, Mexico.Participants: 50 nursing home residents older than 60 yr.Intervention: Randomization to either 2 g/d of fish oil versus 2 g/d of soy oil as the control, with 6 mo follow-up (1-mo presupplementation and 5-mo supplementation) or repeated HRV measurements. PM2.5 was monitored indoors and outdoors.Main Outcome Measure: The association between HRV and 1 SD change in PM2.5 (8 μg/m3).Results: In the group receiving fish oil, the reduction in HRV–high-frequency log10-transformed associated with a 1-SD change in PM2.5 was −54% (95% confidence interval, −72, −24) in the presupplementation phase, and only −7% (95% confidence interval, −20,+7) in the supplementation phase (p < 0.01 for the effect of supplementation), with changes in other HRV parameters also being significantly less pronounced during supplementation. Small decreases in PM2.5-associated reductions in HRV parameters also occurred in the group receiving soy oil, but these were not significant. Fish oil supplementation was significantly better in preventing the reduction in percentage of successive normal RR intervals differing by more than 50 ms (p = 0.03) and the root square of the mean of the sum of the squares of differences between adjacent intervals (p = 0.05) than soy oil supplementation.Interpretation: Supplementation with 2 g/d of fish oil prevented HRV decline related to PM2.5 exposure in the study population.
DJ-1 Binds Androgen Receptor Directly and Mediates Its Activity in Hormonally Treated Prostate Cancer Cells
Authors: J. Erin Tillman, Jialing Yuan, Guangyu Gu, Ladan Fazli, Ritwik Ghosh, Alex S. Flynt, Martin Gleave, Paul S. Rennie, Susan Kasper
Journal: Cancer Research (2007)

Abstract The oncogene DJ-1 has been associated with multiple cancers, including prostate cancer, where it can be stabilized by androgens and antiandrogens. However, little data exist on the expression pattern and function of DJ-1 in prostate cancer. To address the function of DJ-1 in prostate, a yeast two-hybrid screen was done to identify novel DJ-1 binding proteins. The androgen receptor (AR) was identified and confirmed as a DJ-1 binding partner. This is the first evidence that DJ-1 directly interacts with AR. We also show that modulation of DJ-1 expression regulated AR transcriptional activity. Importantly, both the subcellular localization of DJ-1 and the interaction with AR are regulated by androgens and antiandrogens. Additionally, immunohistochemical staining on two human prostate cancer tissue arrays was done providing the first large-scale expression analysis of DJ-1 in prostate. DJ-1 expression did not change with Gleason pattern but increased after androgen deprivation therapy, indicating that it may be involved in the development of androgen independence. These data provide a novel mechanism where DJ-1–mediated regulation of AR may promote the progression of prostate cancer to androgen independence. [Cancer Res 2007;67(10):4630–7]
"Tax" on infertility is increased
Authors: P R Brinsden
Journal: BMJ (1994)

EDITOR, - Further evidence of the government's penny pinching in the provision of health care was shown recently. The Human Fertilisation and Embryology Authority announced to the fertility clinics that it licenses that the fees levied for cycles of in vitro fertilisation are to be increased from pounds sterling 30 to pounds sterling 40 and those levied for donor insemination are to be increased from …
TREATMENT OF ANEURYSMS BY EXTIRPATION: WITH REPORT OF CASE OF POPLITEAL ANEURYSM TREATED BY THIS METHOD.
Authors: JOHN CHADWICK OLIVER
Journal: JAMA (1899)

The following report of a case of traumatic aneurysm of the popliteal artery occurring in a syphilitic subject can be used as the text for a few remarks on the general subject of aneurysms, but more particularly on those which develop in the popliteal space. John Taylor, a strong, well-developed negro, 29 years of age, had enjoyed good health until six years ago, at which time he contracted syphilis. Primary and secondary manifestations left no doubt as to the nature of his malady. He was admitted to my service in the Cincinnati Hospital, Feb. 24, 1899. Four weeks previously he had slipped and in falling had struck his ankle and the outer surface of the left knee against the curbstone. He is not certain as to whether a swelling was immediately apparent, but a dull, throbbing pain was present almost from the time of injury. This pain was always worse
The Future of Medical Care
Authors: Constantine A. Manthous
Journal: JAMA (1991)

<h3>To the Editor.</h3> —The American Medical Association (AMA) recommendations for dealing with the crisis of the medically uninsured fail to address many central health issues that will face our society in the next century. Physicians feel persecuted. The general public has less faith in our profession. Yet the fundamental question is the degree to which we have contributed to the current situation. We like to blame lawyers and insurance companies for the current "crisis" of faith. Physicians in the 1960s and 1970s enjoyed a greater freedom to practice as they liked. They also enjoyed a compensation system that may have led to abuses for which we are paying now. As a group, we have failed to police ourselves so the government has had to intervene. Our inability to self-regulate seems to be a recurrent theme. This country faces a projected shortage of primary care providers. Many of our brightest students
Portable Transfusion Apparatus
Authors: W. Walter
Journal: BMJ (1884)

X Ik 1233'internal blade of the ctanioclut, sand the.ettractioANade is sppliedj outside the scalp, over owciput or face, as -the, ease mar be.We have thus an instmment which will produce a. more efficient, cranioclasm than any cranioclast, and will present all its advantages as a safe and scientifically constructed tractor.Such is this chapter in Midwifery as far as we can read it np tiU the present time.What developements the futurewill bring fortl, I pretend not to foretell.'But I do not doubt that wheathe,evolutiOn of PerforatQr,Comminutor, and Extractor, has oome to the ,full, the obstetrician will not be under.the-necessity of baying voxious, imple*Uents for the various stages.He will save one sinileI .iEplemIent,with which he will be ble to carry out rany or eVry sta;ge of the operation dito et tuto.He would be something less than hnan who could ever think to operate juetundg.
Humanism, History, and Natural Science in Medicine
Authors: F. M. R. Walshe
Journal: BMJ (1950)

A three-year study was conducted to investigate the accumulation of yeast assimilable nitrogen (YAN) during the final weeks of ripening in seven winegrape cultivars grown in New York State and to assess the feasibility of predicting harvest YAN using linear regression models. Berry samples of <i>Vitis vinifera</i> cvs. Cabernet franc, Chardonnay, Merlot, Pinot noir, and Riesling and interspecific hybrid cvs. Noiret and Traminette were collected weekly from 49 vineyard sites across the Finger Lakes, Hudson Valley, Lake Erie, and Long Island growing regions from August through harvest. YAN concentrations in Cabernet franc, Riesling, and Traminette were generally low, averaging &lt;100 mg/L annually, while Chardonnay and Pinot noir had average YAN concentrations &gt;200 mg/L. During the ripening period, linear regression models predicted harvest YAN up to five weeks before harvest (R<sup>2</sup> = 81.6%). A decrease in YAN during ripening was observed across cultivars, caused primarily by decreases in ammonia (AMM), as primary amino nitrogen levels remained stable. Population distributions were used to estimate appropriate prophylactic nitrogen additions for each cultivar, minimizing the risk of deficiency or excess; this was most difficult with Chardonnay, Noiret, and Pinot noir, which had the highest and most variable YAN concentrations and subsequently run the greatest risk of oversupplementation with prophylactic additions.
Classification of stillbirth
Authors: Jan Jaap HM Erwich
Journal: BMJ (2005)

EDITOR—Gardosi et al illustrate the inadequacy of current classification systems and emphasise the preponderance of fetal growth restriction, which, presumably, is not diagnosed before the death occurs.1 Although definition of relevant conditions at death may mute the debate about its cause, the distinction between conditions, causes, or mechanisms of death is still not clear in this …
Evidence for the involvement of CD56 molecules in alloantigen-specific recognition by human natural killer cells.
Authors: N Suzuki, T Suzuki, E G Engleman
Journal: The Journal of Experimental Medicine (1991)

In recent reports we have described the generation of natural killer (NK) lines devoid of CD3/TCR structures but with apparent specificity for allogeneic target cells. Using one such NK line as an immunogen, we now report the generation of two monoclonal antibodies (mAbs), designated 2-13 and 5-38, which bind selectively to the majority of CD3-, CD16+, CD56+ lymphocytes and inhibit the lysis of specific allogeneic target cells by a panel of alloreactive NK lines. By contrast, these mAbs had no effect on classical NK cell mediated lysis of K562 cells or major histocompatibility-restricted T cell-mediated cytolysis. Immunoprecipitation of radiolabeled NK lines followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis revealed that the target molecules of both mAbs have a molecular mass of approximately 180 kD. Leu 19, a well-described anti-CD56 mAb, precipitated a 180 kD protein from NK cells, and the binding of Leu 19 to NK cells was blocked by pretreatment with both 2-13 and 5-38. However, in contrast to these mAbs, Leu 19 had no effect on the cytolytic activity of allospecific NK cells. Sequential immunoprecipitation analysis revealed that all three mAbs recognized distinct molecular species of CD56. We interpret these findings as indicating that multiple isoforms of CD56 are differentially expressed on NK lines and play critical roles in the recognition/interaction of these cells with their specific allogeneic targets.
What's the Beef?
Authors: Christine L. Tolins
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The Journalran an advertisement in the Sept 14 issue by the National Live Stock and Meat Board that will mislead all but the most nutritionally aware physicians. Using the headline, "Announcing some new findings on cholesterol," the ad erroneously implies that beef has miraculously been transformed into a food that rivals flounder, turkey, and chicken in its ability to lower blood cholesterol levels. In fact, beef is still a more potent elevator of blood cholesterol levels than those other foods, because it is relatively fatty and a hefty 48% of its fat is saturated. That tiny 3-oz serving mentioned in the ad contains 4.8 g of saturated fat (Barbara Anderson, US Department of Agriculture Nutrient Data Research Group; oral communication, Oct 1, 1984). In contrast, a 3-oz serving of flounder or skinless turkey or chicken breast contains only 0.3, 0.2, and 0.9 g of saturated fat,
Impact of Mitral Valve Annuloplasty Combined With Revascularization in Patients With Functional Ischemic Mitral Regurgitation
Authors: Tomislav Mihaljevic, Buu-Khanh Lam, Jeevanantham Rajeswaran, Masami Takagaki, Michael S. Lauer, A. Marc Gillinov, Eugene H. Blackstone, Bruce W. Lytle
Journal: Journal of the American College of Cardiology (2007)
Millions of people displaced by Pakistani conflict urgently need international aid
Authors: J. Zarocostas
Journal: BMJ (2009)

Senior World Health Organization and Pakistani health officials have warned that there is a massive need for international health aid to help millions of people caught up in the conflict in northwest Pakistan, described as the worst disaster since the country became independent.

A total of about 2.9 million people have been displaced by ongoing conflict in the area between the government and Taliban militants since August last year.⇓ The United Nations estimates that just since 2 May about 2.4 million people have been uprooted by the latest hostilities, of whom more than 200 000 are living in camps and the rest with relatives and friends or in rented accommodation.



Khalif Bile, WHO’s representative to Pakistan, told reporters on Tuesday 26 May: “There is an acute need for mobile hospitals, ambulances, mobile health services, …
Lidocaine Therapy with an Exponentially Declining Infusion
Authors: ROLF J. SEBALDT
Journal: Annals of Internal Medicine (1984)

A novel technique to achieve rapidly and continually maintain therapeutic lidocaine concentrations was designed according to known pharmacokinetic properties of the drug and was tested in 12 patients who required immediate lidocaine prophylaxis because of suspected acute myocardial infarction. The serum lidocaine concentrations achieved by this method remained within the therapeutic range (1.2 to 5.0 mg/L) in 83 of 84 determinations and showed little fluctuation over time for individual patients. Unlike previously recommended dose regimens for lidocaine, this technique uses an exponentially declining infusion and has the advantages of greater simplicity, less chance of medication error, and avoidance of rapid changes of lidocaine concentrations. Furthermore, similar methods can be applied when rapid attainment of stable plasma drug concentrations is needed for clinical or experimental pharmacologic studies.
Attenuation of allergic inflammation by neutralization of IGF-I in murine asthmatic models
Authors: N. Yamashita, H. Tashimo, M. Nakajima, H. Ishida, M. Kuramochi, F. Kaneko, R. Kawashima, T. Horiuchi, K. Ohta
Journal: Journal of Allergy and Clinical Immunology (2003)
Androgen Receptor Splice Variants Determine Taxane Sensitivity in Prostate Cancer
Authors: Maria Thadani-Mulero, Luigi Portella, Shihua Sun, Matthew Sung, Alexandre Matov, Robert L. Vessella, Eva Corey, David M. Nanus, Stephen R. Plymate, Paraskevi Giannakakou
Journal: Cancer Research (2014)

Abstract Prostate cancer growth depends on androgen receptor signaling. Androgen ablation therapy induces expression of constitutively active androgen receptor splice variants that drive disease progression. Taxanes are a standard of care therapy in castration-resistant prostate cancer (CRPC); however, mechanisms underlying the clinical activity of taxanes are poorly understood. Recent work suggests that the microtubule network of prostate cells is critical for androgen receptor nuclear translocation and activity. In this study, we used a set of androgen receptor deletion mutants to identify the microtubule-binding domain of the androgen receptor, which encompasses the DNA binding domain plus hinge region. We report that two clinically relevant androgen receptor splice variants, ARv567 and ARv7, differentially associate with microtubules and dynein motor protein, thereby resulting in differential taxane sensitivity in vitro and in vivo. ARv7, which lacks the hinge region, did not co-sediment with microtubules or coprecipitate with dynein motor protein, unlike ARv567. Mechanistic investigations revealed that the nuclear accumulation and transcriptional activity of ARv7 was unaffected by taxane treatment. In contrast, the microtubule-interacting splice variant ARv567 was sensitive to taxane-induced microtubule stabilization. In ARv567-expressing LuCap86.2 tumor xenografts, docetaxel treatment was highly efficacious, whereas ARv7-expressing LuCap23.1 tumor xenografts displayed docetaxel resistance. Our results suggest that androgen receptor variants that accumulate in CRPC cells utilize distinct pathways of nuclear import that affect the antitumor efficacy of taxanes, suggesting a mechanistic rationale to customize treatments for patients with CRPC, which might improve outcomes. Cancer Res; 74(8); 2270–82. ©2014 AACR.
Residency Positions
Authors: Anne E. Crowley
Journal: JAMA (1984)

This article presents data on postgraduate year 1 positions in US residency programs. It points out the distinctions between data published annually in the Directory of Residency Training Programs and the data reported by the National Resident Matching Program on the subject of positions. On the basis of data reported from all accredited programs there were 1.3 positions for each US medical school graduate in 1983. The number of US graduates is expected to decrease in future years. The number of foreign medical graduates in residency programs is not increasing; however, the proportion of foreign graduates who are US citizens is increasing.
Incidence of postoperative deep vein thrombosis in Nigerians using 125I-labelled fibrinogen.
Authors: U Osime
Journal: BMJ (1978)

doctor's awareness about current drug treatment, and is in the overall interests of patient care.We thank all doctors in ward 4, Aberdeen Royal Infirmary, and ward 3, Woodend General Hospital, who participated in this study and gave helpful advice.We also acknowledge the financial support of the DHSS and SHHD to the Medicines Evaluation and Monitoring Group.
Apnea and Respiratory Distress in the Newborn Infant
Authors: C. D. Cook, J. F. Lucey, J. E. Drorbaugh, S. Segal, J. M. Sutherland, C. A. Smith
Journal: New England Journal of Medicine (1956)

APNEA and later respiratory distress of unknown etiology are the two types of respiratory problems that are most important in the newborn period. Their physiologic background is the subject of the first part of this review. Technics of resuscitation in cases of apnea, supportive therapy in the respiratory-distress syndrome and, where possible, the prevention of both are considered in the second and third sections. Although the details of the clinical, roentgenologic and pathological aspects of respiratory problems in the newborn and their differential diagnosis will be presented in a subsequent review, a summary of the principal etiologic possibilities is given . . .
Estimating Excess Mortality in Post-Invasion Iraq
Authors: Catherine A. Brownstein, John S. Brownstein
Journal: New England Journal of Medicine (2008)

In a military invasion and ongoing war, the likelihood of obtaining good demographic data plummets. Catherine Brownstein and John Brownstein discuss the accuracy of the data from the Iraq Family Health Survey. Dr. Mohamed Ali discusses violence-related mortality among Iraqi civilians and the methods used to assess health and mortality in a war zone. Dr. Ali is a statistician in the Department of Measurement and Health Information Systems at the World Health Organization in Geneva, Switzerland.