Vancomycin Ototoxicity in a Patient with Normal Renal Function
Authors: Peter G. Traber, Donald P. Levine
Journal: Annals of Internal Medicine (1981)

Brief Reports1 October 1981Vancomycin Ototoxicity in a Patient with Normal Renal FunctionPETER G. TRABER, M.D., DONALD P. LEVINE, M.D.PETER G. TRABER, M.D., DONALD P. LEVINE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-4-458 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite its apparent efficacy against gram-positive organisms, vancomycin has been relegated to second-choice status, largely because of reports of auditory and nephrotoxicity. The increased purity of today's preparations has virtually elemented the risk of nephrotoxicity (1). Ototoxicity, however, is still considered a threat in patients with impaired renal function, despite the fact that all the evidence comes from reports of patients who received other ototoxic drugs or who had pre-existing deafness (1-3). We review the relevant literature and report a case of ototoxicity in a patient with normal renal function who was treated with vancomycin and rifampin but no other...References1. APPELNEU GH. The nephrotoxicity of antimicrobial agents. N Engl J Med. 1977;296:722-8. CrossrefMedlineGoogle Scholar2. ESPOSITOGLECKMAN AR. Vancomycin: a second look. JAMA. 1977;238:1756-7. CrossrefMedlineGoogle Scholar3. COOKFARRAR FW. Vancomycin revisited. Ann Intern Med. 1978;88:813-8. LinkGoogle Scholar4. GERACIHEILMANNICHOLSWELLMAN JFDW. Antibiotic therapy of bacterial endocarditis: VII. Vancomycin for acute micrococcal endocarditis: preliminary report. Proc Mayo Clin. 1958;33:172-81. MedlineGoogle Scholar5. GERACIHEILMAN JF. Vancomycin in the treatment of staphyloccal endocarditis. Mayo Clin Proc. 1960;35:316-26. MedlineGoogle Scholar6. WAISBRENKLEINERMANSKEMPBRATCHER BLJG. Comparative clinical effectiveness and toxicity of vancomycin, ristocetin, and kanamycin. Arch Intern Med. 1960;106:179-93. CrossrefGoogle Scholar7. KIRBYPERRYBAUER WDA. Treatment of staphylococcal septicemia with vancomycin: report of thirty-three cases. N Engl J Med. 1960;262:49-55. CrossrefMedlineGoogle Scholar8. DANGERFIELDHEWITTMONZONKUDINOFFBLACKMANFINEGOLD HWOZBS. Clinical use of vancomycin. Antimicrob Agents Ann. 1960;428-37. Google Scholar9. HOOKJOHNSON EW. Vancomycin therapy of bacterial endocarditis. Am J Med. 1978;65:411-5. CrossrefMedlineGoogle Scholar10. WOODLEYHULL DW. The treatment of severe staphylococcal infections with vancomycin. Ann Intern Med. 1961;55:235-49. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit Receiving Hospital Wayne State University Detroit, Michigan. 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SNAVELY, M.D., GLENN R. HODGES, M.D.Use of Drugs in Uremia and DialysisVancomycin ototoxicity in patients with normal renal functionComparison of radioimmunoassay and fluorescent polarization immunoassay for quantitative determination of vancomycin concentrations in serumVancomycinCommunity-Acquired Methicillin-Resistant Staphylococcus aureus Endocarditis in the Detroit Medical CenterDONALD P. LEVINE, M.D., RALPH D. CUSHING, M.D., JONATHAN JUI, M.D., WILLIAM J. BROWN, Ph.D.Vancomycin Therapy for Methicillin-Resistant Staphylococcus aureusTANIA C. SORRELL, M.B., B.S., M.D., DONALD R. PACKHAM, M.B., B.S., SIVARAJ SHANKER, B.Sc., MARY FOLDES, B.Sc., ROSEMARY MUNRO, M.B., B.S.Treatment of Infections Due to Methicillin-Resistant Staphylococcus aureusCHATRCHAI WATANAKUNAKORN, M. D.Hörstörungen 1 October 1981Volume 95, Issue 4Page: 458-460KeywordsDeafnessDrugsHospital medicineInfectious diseasesVancomycin Issue Published: 1 October 1981 PDF DownloadLoading ...