tbuckley/cabot-search huggingface dataset:
Engineering and physiological approaches to the study of cardiovascular function
Authors: K. H Parker, J. N Amoore
Journal: Cardiovascular Research (1992)

Journal Article Engineering and physiological approaches to the study of cardiovascular function Get access Kim H Parker, Kim H Parker Search for other works by this author on: Oxford Academic PubMed Google Scholar John N Amoore John N Amoore Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 3, March 1992, Pages 301–302, https://doi.org/10.1093/cvr/26.3.301 Published: 01 March 1992
Toward PKU Enzyme Replacement Therapy: PEGylation with Activity Retention for Three Forms of Recombinant Phenylalanine Hydroxylase
Authors: Alejandra Gámez, Lin Wang, Mary Straub, Marianne G Patch, Raymond C Stevens
Journal: Molecular Therapy (2003)

Phenylketonuria (PKU) is a disease in which phenylalanine and phenylalanine-derived metabolites build up to neurotoxic levels due to mutations in the phenylalanine hydroxylase gene (PAH). Enzyme replacement therapy is a viable option to supply active PAH. However, the inherent protease sensitivity and potential immunogenicity of PAH have precluded adoption of this approach. In this report, we have used polyethylene glycol derivatization (PEGylation) to produce protected forms of PAH for potential therapeutic use. Three recombinantly produced PAH enzymes were reacted with activated PEG species, with the aim of developing a stable and active PKU enzyme replacement. Tetrameric full-length human PAH, dimeric double-truncated (DeltaN102-DeltaC428) human PAH, and monomeric Chromobacterium violaceum PAH were PEGylated with succinimidyl succinate polyethylene glycol of molecular weight 5000 or 20,000 Da. Characterization of the PEGylated species was accomplished with MALDI-TOF mass spectrometry, SDS-PAGE, and specific activity measurements using ESI mass spectrometry. All PEG-derivatized PAH species retained catalytic activity, and, at low numbers of PEG molecules attached, these PEGylated PAH proteins were found to be more active and more stable than their non-derivatized PAH counterparts.
P711 A NOVEL GENETIC MAKER TO IMPROVE THE PREDICTION OF HCV SPONTANEOUS CLEARANCE: POLYMORPHISMS CONSISTING OF (TA)N DINUCLEOTIDE REPEAT NEAR IL28B GENE
Authors: M. Sugiyama, S. Hiramine, N. Furusyo, A. Ido, H. Tsubouchi, H. Watanabe, Y. Ueno, M. Korenaga, K. Murata, N. Masaki, J. Hayashi, M. Mizokami
Journal: Journal of Hepatology (2014)
Unraveling the mechanism of action of thiazolidinediones
Authors: C. Ronald Kahn, Lihong Chen, Shmuel E. Cohen
Journal: Journal of Clinical Investigation (2000)

Thiazolidinediones (TZDs) are a new class of antidiabetic agents and include three compounds that have come to clinical use — troglitazone (Rezulin®), rosiglitazone (Avandia®), and pioglitazone (Actos®) — as well as several others that have been limited to pre-clinical study. TZDs were initially discovered by screening compounds for a hypoglycemic action in the ob/ob mouse (1), and subsequently they were shown to improve insulin action in a variety of obese and diabetic animal models with insulin resistance (2). In these model systems, TZDs reduce plasma glucose and insulin levels and improve some of the abnormalities of lipid metabolism. Consistent with animal studies, clinical studies have shown that treatment of type 2 diabetic patients with TZDs can lower serum glucose and insulin levels, increase peripheral glucose uptake, and decrease triglyceride levels (3). In euglycemic clamp studies, this is associated with an increase in insulin sensitivity in peripheral tissues (mainly represented by muscle in clamp studies), with relatively little effect on hepatic glucose output (4).
Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection
Authors: Pisana Moroni Rawson, Caroline Molette, Melissa Videtta, Laura Altieri, Debora Franceschini, Tiziana Donato, Luigi Finocchi, Antonella Propato, Marino Paroli, Francesca Meloni, Claudio M Mastroianni, Gabriella d'Ettorre, John Sidney, Alessandro Sette, Vincenzo Barnaba
Journal: Nature Medicine (2007)
Treatment of Pulmonary Hemangiomatosis with Recombinant Interferon Alfa-2a
Authors: Carl W. White, Henry M. Sondheimer, Edmond C. Crouch, Harry Wilson, Leland L. Fan
Journal: New England Journal of Medicine (1989)

PULMONARY hemangiomatosis is a rare, fatal disorder characterized by diffuse microvascular proliferation within the lung. The disease most often affects children and young adults and usually progresses rapidly, causing death from pulmonary hypertension or bleeding. Most cases have been diagnosed at autopsy. Corticosteroids and cyclophosphamide have been used for this condition, but no successful therapy has been described.We describe a patient with pulmonary hemangiomatosis who presented with digital clubbing and bilateral interstitial pulmonary disease. After a decline in the patient's exercise tolerance, therapy with interferon alfa-2a was initiated and has been continued for 14 months at the time of . . .
Effect of prophylactic cyclosporine therapy on ADAMTS13 biomarkers in patients with idiopathic thrombotic thrombocytopenic purpura
Authors: Spero R. Cataland, Ming Jin, Shili Lin, Eric H. Kraut, James N. George, Haifeng M. Wu
Journal: American Journal of Hematology (2008)

Several reports have been published regarding the use of cyclosporine (CSA) in the treatment of idiopathic thrombotic thrombocytopenic purpura (TTP). We hypothesized that prophylactic CSA therapy may prevent recurrences in patients with a history of multiple relapses of TTP. Nineteen patients with idiopathic TTP were enrolled on prospective studies at Ohio State University between September 2003 and May 2007. Patients achieving remission remained on CSA therapy for 6 months, allowing us to evaluate the efficacy of CSA as prophylactic therapy. CSA was administered orally at a dose of 2-3 mg/kg in twice a day divided dose in all patients and continued for a total of 6 months. Long-term clinical follow-up with serial analysis of ADAMTS13 biomarkers during and after CSA therapy were performed to evaluate the efficacy of CSA as a prophylactic therapy. 17/19(89%) patients completed 6 months of CSA therapy in a continuous remission. Two patients relapsed during therapy with CSA and seven patients relapsed after discontinuing CSA therapy. Ten patients have maintained a continuous remission a median of 21 months (range, 5-46) after discontinuing CSA. The ADAMTS13 data suggest that CSA resulted in a significant increase in the ADAMTS13 activity during therapy with CSA. 8/9(89%) relapsing patients had severely deficient ADAMTS13 activity (<5%) suggesting this is a significant risk factor for relapse of TTP. These data support the hypothesis that prophylactic CSA improves the ADAMTS13 activity and may be effective at preventing relapses in patients at risk for recurrences of TTP.
Textbook of Respiratory Medicine
Authors: Edward D. Sivak
Journal: JAMA (1989)

Making a decision to purchase a text of the magnitude of Murray and Nadel's<i>Textbook of Respiratory Medicine</i>requires careful consideration of its assets and liabilities. Assets can be found by review from the far side and liabilities from the near side. For those in search of a quick, executive decision, the assets far exceed the liabilities. For those who are more operationally inclined, some justification is necessary. On first pass, one might question whether this text has any liabilities. Hence, the near side, myopic approach is necessary to find them. Notable deficiencies begin in the discussion of respiratory muscle fatigue, which has little on electromyographical findings and their important contributions to our understanding of this process. Ipatropium bromide receives but a few sentences in the discussion of the pharmacologic agents used to treat bronchospasm. The lack of discussion on a therapeutic approach to chronic cough is a disappointment. Preoperative
Some sudden unexpected deaths in infancy may be avoidable
Authors: R. Harling
Journal: BMJ (1998)

Over half of investigated, sudden, unexpected deaths in infancy with an identifiable cause could be avoided, according to the fifth annual report of the confidential inquiry into stillbirths and deaths in infancy, published this week.

The study first reviewed all 456 deaths in infants aged 1-52 weeks that occurred in five English regions in 1993-6. In 363 cases no adequate explanation for …
Snuff Dipping and Oral Cancer among Women in the Southern United States
Authors: Deborah M. Winn, William J. Blot, Carl M. Shy, Linda Williams Pickle, Ann Toledo, Joseph F. Fraumeni
Journal: New England Journal of Medicine (1981)

A case-control study in North Carolina involving 255 women with oral and pharyngeal cancer and 502 controls revealed that the exceptionally high mortality from this cancer among white women in the South is primarily related to chronic use of snuff. The relative risk associated with snuff dipping among white nonsmokers was 4.2 (95 per cent confidence limits, 2.6 to 6.7), and among chronic users the risk approached 50-fold for cancers of the gum and buccal mucosa--tissues that come in direct contact with the tobacco powder. In the absence of snuff dipping, oral and pharyngeal cancer resulted mainly from the combined effects of cigarette smoking and alcohol consumption. The carcinogenic hazard of oral snuff is of special concern in view of the recent upswing in consumption of smokeless tobacco in the United States.
PLASMAPHERESIS FOR LATE-STAGE TRYPANOSOMIASIS
Authors: F. Spinazzola, A. De Felici, M.G. Paglia, G. Tocci, S. Galgani, C. D'Amato, R. Giannuzzi, C. Struglia, G. Visco, E. Cotroneo
Journal: The Lancet (1989)
The cell proliferation kinetics of psoriasis examined by three in vivo techniques
Authors: MARK DUFFILL, NICHOLAS WRIGHT, SAM SHUSTER
Journal: British Journal of Dermatology (1976)

The cell proliferation kinetics of the germinative compartment in psoriasis have been re-investigated with tritiated thymidine and vincristine techniques. The mean cell cycle durations calculated from an extended fraction of labelled mitoses experiment were Tc=56 h, t1=43 h, ts=7-7 h and t2=5-6 h. Combination of the results of the FLM experiment with the experimental labelling index and the experimental birth rate suggests a growth fraction of unity and an exponential age distribution for the germinative population. An exponential age distribution is supported by the presence of several layers of germinative cells and the direction of the mitotic axes during cell division.
Mammalian Circadian Autoregulatory Loop
Authors: Ashvin M Sangoram, Lino Saez, Marina P Antoch, Nicholas Gekakis, David Staknis, Andrew Whiteley, Ethan M Fruechte, Martha Hotz Vitaterna, Kazuhiro Shimomura, David P King, Michael W Young, Charles J Weitz, Joseph S Takahashi
Journal: Neuron (1998)
Experimental Reversal of Capillary Blood Flow
Authors: RAY HEIMBECKER, VIVIEN THOMAS, ALFRED BLALOCK
Journal: Circulation (1951)

Beck, Sciaroni and others have made clinical and experimental attempts to reverse the direction of flow of blood across the capillary bed by the anastomosis of arteries and veins. The present authors have shown by the microscopic observation of capillaries in acute experiments on cats, dogs and rabbits that a reversal of blood flow in mesenteric capillaries will occur following the connection of an artery to a vein provided the collateral arteries and veins are obstructed. Furthermore, it was shown that blood flowing in a reverse direction through capillaries loses oxygen.
What is the source of activation for working memory?
Authors: John Jonides, Edward Awh
Journal: Behavioral and Brain Sciences (2003)

Attentional processes that operate on the contents of memory to produce the activation that is described as working memory by Ruchkin et al. and others, involve a network of brain regions that include both prefrontal and parietal sites. This network appears to mimic the one that is activated by attentional processes that operate on information entering via the senses.
Tobramycin Solution for Inhalation Reduces Sputum <i>Pseudomonas aeruginosa</i> Density in Bronchiectasis
Authors: ALAN F. BARKER, LESLIE COUCH, STANLEY B. FIEL, MARK H. GOTFRIED, JONATHAN ILOWITE, KEITH C. MEYER, ANNE O'DONNELL, STEVEN A. SAHN, LEWIS J. SMITH, JACK O. STEWART, TAMMY ABUAN, HEATHER TULLY, JILL VAN DALFSEN, CHARLES D. WELLS, JOANNE QUAN
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

We conducted a placebo-controlled, double-blind, randomized study to evaluate the microbiological efficacy and safety of inhaled tobramycin for treatment of patients with bronchiectasis and Pseudomonas aeruginosa. Patients were randomly assigned to receive either tobramycin solution for inhalation (TSI) (n = 37) or placebo (n = 37), which was self-administered twice daily for 4 wk and followed by 2-wk off-drug. At Week 4, the TSI group had a mean decrease in P. aeruginosa density of 4.54 log10 colony-forming units (cfu)/g sputum compared with no change in the placebo group (p < 0.01). At Week 6, P. aeruginosa was eradicated in 35% of TSI patients but was detected in all placebo patients. Investigators indicated that 62% of TSI patients showed an improved medical condition compared with 38% of placebo patients (odds ratio = 2.7, 95% confidence interval [CI] 1.1 to 6.9). Tobramycin-resistant P. aeruginosa strains developed in 11% of TSI patients and 3% of placebo patients (p = 0.36). The mean percent change in FEV1 percent predicted from Week 0 to Week 4 was similar for the TSI and placebo groups (p = 0.41). More TSI-treated patients than placebo patients reported increased cough, dyspnea, wheezing, and noncardiac chest pain, but the symptoms did not limit therapy. Additional study is warranted to further evaluate TSI in bronchiectasis patients.
A Textbook of Surgical Physiology
Authors: Samuel P. Harbison
Journal: JAMA (1965)

question is often asked, Why a textbook of surgical physiology as distinct from clinical physiology? I believe this volume answers that question quite adequately. At the beginning of most chapters the authors have devoted a paragraph to explain what the interest of the surgeon should be in this subject, why this is so, and what will be included. Obviously, considerable thought has been devoted to content specifically for the surgeon. An example is the following, from the chapter on bone:  Bone is of chief importance to the surgeon as a supporting tissue, and it is solely with this function that the present chapter is concerned.  The structure of bone, and the mechanism of bone growth, are of theoretical interest, discussed briefly.  healing of fractures and the behavior of bone grafts are of practical importance. A discussion of the strength of bone as a material, and of the metabolism
Combating fuzziness with computational modeling
Authors: L. M. Talamini, M. Meeter, J. M. J. Murre
Journal: Behavioral and Brain Sciences (2003)

Abstract Phillips &amp; Silverstein's ambitious link between receptor abnormalities and the symptoms of schizophrenia involves a certain amount of fuzziness: No detailed mechanism is suggested through which the proposed abnormality would lead to psychological traits. We propose that detailed simulation of brain regions, using model neural networks, can aid in understanding the relation between biological abnormality and psychological dysfunction in schizophrenia.
Allergy screening using a microcomputer.
Authors: C F Pantin, T G Merrett
Journal: BMJ (1982)

Data are presented to show that a microcomputer can be programmed to: (1) analyse a standard allergy questionnaire, (2) reliably predict the ranked order probabilities with which IgE antibody tests will produce positive results, (3) store the IgE test results, and (4) print a comprehensive report that summarises and integrates the clinical and laboratory data. Consequently, the practitioner who refers a blood sample and a questionnaire completed by the patient to a centre where both can be analysed will obtain enough practical information to decide whether to treat or refer that patient to a specialist. The microcomputer is therefore potentially of great value in any preliminary allergy investigation.
When I Die
Authors: Donna Pucciani
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Weighing in Before the Fight
Authors: Margo A. Denke
Journal: Circulation (2005)

n this issue of Circulation, Pischon and colleagues 1 present provocative data pitting the power of non-highdensity lipoprotein cholesterol (non-HDL-C) versus apolipoprotein (apo) B to predict coronary heart disease (CHD) development in healthy men.They conclude not only that apoB is a superior predictor of CHD risk but, in addition, that "the practical application of our findings would be the substitution of apoB for LDL-C and non-HDL-C for screening and treatment of CHD risk.
A CASE OF ERYTHRODERMA SQUAMOSUM.
Authors: A. RAVOGLI
Journal: JAMA (1901)

A group of mild affections of the skin of a transitory nature, characterized by a desquamation of the epidermis, was called pityriasis by Bateman. Biett gave a more definite meaning to pityriasis, which he considered a mild chronic inflammatory process of the most superficial layers of the derma, accompanied with continuous exfoliation of small epidermic scales. Devergie gave an interesting description of pityriasis, which he called rubra, and we can say that he established a new pathological entity. Pityriasis rubra (Devergie), however, has nothing to do with another disease of squamous nature, which was after a while described by F. and H. Hebra under the name of pityriasis rubra. F. Hebra<sup>1</sup>said that the name pityriasis rubra could be given to any disease of the skin which during its whole course was not accompanied by any other symptoms but a constant, intense, brownish-red discoloration, without marked infiltration, without formation of
The Role of Claudin- 5 and the Paracellular Barrier Function in Endothelial Cells during Invasion of Breast Cancer Cells.
Authors: A. Escudero-Esparza, T. Martin, W. Jiang
Journal: Cancer Research (2009)

Abstract Material and Methods: Human endothelial (HECV) and breast cancer cells (MDA-MB-231) were used to assess the effect of over-expression (HECVCL-5, MDACL-5) or knockdown (HECVDCL-5, MDADCL-5) of Claudin-5. Cell adhesion and growth were evaluated using in vitro assays. An in vivo tumour model using athymic nude mice was used to assess growth of tumours. Transendothelial and transepithelial resistance (TER) was employed to measure changes in TJ function. Cellular motility was analyzed using Cytodex-2 bead motility assay. ECIS (electrical cell impedance sensing) was used to assess the attachment and migration of the cells.Results: There were no significant differences in in vitro growth of cells that over-expressed or had knockdown of Claudin-5 (both HECV and MDA-MB-231 cells). Expression of CL5 in both HECV and MDA-MB-231 did not have a significant impact on in vivo growth. There were however, significant differences in adhesion between control cells (HEVCpEF6) and HECVCL-5, HECVDCL-5 (changes in adhesion: HEVC pEF6 vs. HECVCL-, P&amp;gt;0.05; HECVDCL-5, P=0.046). There was a distinct modulation of TJ function as assessed using TER. HECVDCL-5 cells exhibited increased resistance compared to HEVC pEF6 and HECVCL-5 (change in TER: HEVC pEF6: -151.33±6.11 vs. HECVCL-5 -187±1.73, HECVDCL-5-89.33±2.08, P &amp;lt;0.01). There was no difference in TER in MDA CL-5 and MDADCL-5cells. HGF, a powerful motogen and modulator of TJ function, caused a significant increase in TER in HECVCL-5 and HECVDCL-5, but resulted in a significant decrease in TER in MDA-MB-231 cells. Motility studies revealed that HECVCL-5 and MDA CL-5 after treatment with HGF cells were significantly more motile than cells without treatment (HECVCL-5 vs. HECVCL-5+HGF, P=0.015; MDACL-5 vs. MDACL-5+HGF, P=0.033). There was no difference in motility in HECVDCL-5 cells, however, MDADCL-5 cells were significantly less motile after treatment with HGF (P=0.017). Interestingly, ECIS results showed that the ROCK inhibitor Y27632 inhibited the attachment and migration of HECVCL-5 cells but was no longer able to inhibit attachment and migration of HECVDCL-5 cells.Discussion: These results demonstrate for the first time that Claudin-5 can be modulated to effect changes in cell motility, attachment and TJ function in human endothelial and breast cancer cells. Moreover, there appears to be a link between Claudin-5 expression and cell motility, particularly with respect to the ROCK signalling cascade. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 6170.
The Sewing Needle and the Knee
Authors: Robert H. Ramsey
Journal: JAMA (1967)

A study of 21 cases of sewing needle fragments accidentally broken off in and about the knee joint demonstrates a uniform mechanism of injury. Penetration occurs with the patient kneeling on a carpet into which the needle has lodged. The needle is broken by the sudden extension of the knee in reaction to the pain. Full appreciation of the mechanism of injury should all but eliminate major difficulty (nine of the 21 cases in this series) in surgical recovery of the retained needle fragment.
ADDENDA TO THERAPEUTIC MEASURES IN CERTAIN FORMS OF NEPHRITIS.
Authors: F. M. JOHNSON
Journal: JAMA (1906)

It is a recognized fact that the therapeutic agents now known and made use of are entirely inadequate satisfactorily to check the progress of diseases belonging to the kidney. This is true in spite of the constant additions of drugs and other remedies to our list of available measures. I appreciate most keenly that the physician busy in general practice is well-nigh overwhelmed by the so-called new methods which come into vogue. It is with some hesitation that I stand before you as an earnest advocate of lavage of the renal pelves as an addition to the usual medication in certain types of nephritis. Each true physician, however, is likewise a true student, and the goal of his most intense desire should be to give to his patients in the way of treatment only the very best that can be obtained from every possible source. We therefore must become co-workers
A Multicenter Assessment of the Use of Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging With Appropriateness Criteria
Authors: Robert C. Hendel, Manuel Cerqueira, Pamela S. Douglas, Karen C. Caruth, Joseph M. Allen, Neil C. Jensen, Wenqin Pan, Ralph Brindis, Michael Wolk
Journal: Journal of the American College of Cardiology (2010)