tbuckley/cabot-search huggingface dataset:
SPINK5 polymorphism is associated with disease severity and food allergy in children with atopic dermatitis
Authors: Takashi Kusunoki, Ikuo Okafuji, Takakazu Yoshioka, Megumu Saito, Ryuta Nishikomori, Toshio Heike, Manabu Sugai, Akira Shimizu, Tatsutoshi Nakahata
Journal: Journal of Allergy and Clinical Immunology (2005)
Report Offers Clinicians Guidance for Treating Depression During Pregnancy
Authors: Mike Mitka
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neural crest cells are required for correct positioning of the developing outflow cushions and pattern the arterial valve leaflets
Authors: Helen M. Phillips, Pavithra Mahendran, Esha Singh, Robert H. Anderson, Bill Chaudhry, Deborah J. Henderson
Journal: Cardiovascular Research (2013)

Anomalies of the arterial valves, principally bicuspid aortic valve (BAV), are the most common congenital anomalies. The cellular mechanisms that underlie arterial valve development are poorly understood. While it is known that the valve leaflets derive from the outflow cushions, which are populated by cells derived from the endothelium and neural crest cells (NCCs), the mechanism by which these cushions are sculpted to form the leaflets of the arterial valves remains unresolved. We set out to investigate how NCCs participate in arterial valve formation, reasoning that disrupting NCC within the developing outflow cushions would result in arterial valve anomalies, in the process elucidating the normal mechanism of arterial valve leaflet formation. By disrupting Rho kinase signalling specifically in NCC using transgenic mice and primary cultures, we show that NCC condensation within the cardiac jelly is required for correct positioning of the outflow cushions. Moreover, we show that this process is essential for normal patterning of the arterial valve leaflets with disruption leading to a spectrum of valve leaflet patterning anomalies, abnormal positioning of the orifices of the coronary arteries, and abnormalities of the arterial wall. NCCs are required at earlier stages of arterial valve development than previously recognized, playing essential roles in positioning the cushions, and patterning the valve leaflets. Abnormalities in the process of NCC condensation at early stages of outflow cushion formation may provide a common mechanism underlying BAV, and also explain the link with arterial wall anomalies and outflow malalignment defects.
Lhermitte's Sign and Cobalamin Deficiency
Authors: David Martin
Journal: JAMA (1982)

<h3>To the Editor.—</h3> Soon after the case reports appeared by Butler et al describing Lhermitte's sign as an early finding of cobalamin deficiency (1981;245:1059), a 77-year-old man came to our geriatric clinic complaining of "electric shock-like" dysesthesias in both upper extremities. The maneuver most likely to precipitate the dysesthesis was forward flexion of the head while using the upper extremities. A physical examination with special attention to the posterior column function was unremarkable. The patient's hemoglobin level was 13.5 g/ dL, and the mean corpuscular volume was 102 femtoliters. There was no hypersegmentation of polymorphonuclear cells. The serum cobalamin level was depressed at 84 pg/dL (normal, 120 to 270 pg/dL), and a repeated test confirmed that the patient's level was well below the 95% confidence limit for the test. A Schilling's test showed normal absorption of crystalline cyanocobalamin Co 57. Treatment with parenterally administered cyanocobalamin alleviated the patient's symptoms. This
Optimism and surgeons
Authors: T Smith
Journal: BMJ (1994)

What determines the choice of specialty for young doctors? Some ask advice from their seniors, but mostly people seem to make up their own minds and have a go at their first choice. We've all come across examples of men or women students of apparently average ability but a great personal ambition and high self esteem who have singlemindedly pressed on to become consultants in prestige disciplines - or the contrast, the clever students who seem unwilling to challenge themselves and risk failure and so have opted for a quiet career in a noncompetitive backwater (such as journalism).

Nowadays, however, …
Katanin p80 Regulates Human Cortical Development by Limiting Centriole and Cilia Number
Authors: Wen F. Hu, Oz Pomp, Tawfeg Ben-Omran, Andrew Kodani, Katrin Henke, Ganeshwaran H. Mochida, Timothy W. Yu, Mollie B. Woodworth, Carine Bonnard, Grace Selva Raj, Thong Teck Tan, Hanan Hamamy, Amira Masri, Mohammad Shboul, Muna Al Saffar, Jennifer N. Partlow, Mohammed Al-Dosari, Anas Alazami, Mohammed Alowain, Fowzan S. Alkuraya, Jeremy F. Reiter, Matthew P. Harris, Bruno Reversade, Christopher A. Walsh
Journal: Neuron (2014)
Fishman's Pulmonary Diseases and Disorders, vols 1 &amp; 2
Authors: T. L. Petty
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mechanism of the Antidiuretic Effect Associated with Interruption of Parasympathetic Pathways
Authors: Robert W. Schrier, Tomas Berl, Judith A. Harbottle
Journal: Journal of Clinical Investigation (1972)

The present experiments were undertaken to investigate the mechanism whereby the parasympathetic nervous system may be involved in the renal regulation of solute-free water excretion. The effects of interruption of parasympathetic pathways by bilateral cervical vagotomy were examined in eight normal and seven hypophysectomized anesthetized dogs undergoing a water diuresis. In the normal animals cervical vagotomy decreased free-water clearance (CH2O) from 2.59±0.4 se to −0.26±0.1 ml/min (P < 0.001), and urinary osmolality (Uosm) increased from 86±7 to 396±60 mOsm/kg (P < 0.001). This antidiuretic effect was not associated with changes in cardiac output, renal perfusion pressure, glomerular filtration rate, renal vascular resistance, or filtration fraction and was not affected by renal denervation. A small but significant increase in urinary sodium and potassium excretion was observed after vagotomy in these normal animals. Pharmacological blockade of parasympathetic efferent pathways with atropine, curare, or both was not associated with an alteration in either renal hemodynamics or renal diluting capacity. In contrast to the results in normal animals, cervical vagotomy was not associated with an antidiuretic effect in hypophysectomized animals. CH2O was 2.29±0.26 ml/min before and 2.41±0.3 ml/min after vagotomy, and Uosm was 88±9.5 mOsm/kg before vagotomy and 78±8.6 mOsm/kg after vagotomy in the hypophysectomized animals. Changes in systemic or renal hemodynamics or electrolyte excretion were also not observed after vagotomy in these hypophysectomized animals. On the basis of these results, we conclude that the antidiuretic effect associated with cervical vagotomy is initiated by interruption of parasympathetic afferent pathways and is mediated by increased endogenous release of vasopressin. This antidiuresis was also demonstrated to occur in the absence of renal nerves and alterations in systemic and renal hemodynamics.
Sunburn and neuropeptide depletion
Authors: P.M. Farr, Sam Shuster
Journal: British Journal of Dermatology (1995)

Journal Article Sunburn and neuropeptide depletion Get access P.M. Farr, P.M. Farr Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, U.K. Search for other works by this author on: Oxford Academic Google Scholar Sam Shuster Sam Shuster Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 133, Issue 6, 1 December 1995, Page 1012, https://doi.org/10.1111/j.1365-2133.1995.tb06949.x Published: 01 December 1995
Life before Birth
Authors: Nicholas M Fisk
Journal: BMJ (2005)

Channel 4, 7 April at 9 pm Rating:![Graphic][1]</img>![Graphic][2]</img> T wo things stand out about this kaleidoscopic odyssey from conception to birth. The first is the realistic animations, which make for gripping television. The second is the juxtaposition of the scientific with the touchy feely, which decidedly does not. Insightful demonstrations of the complex processes of fertilisation, embryology, and fetoplacental development are interwoven with fetal poetry. Novel, yes, but biological lucidity becomes stretched when the fetus announces in the first person its implantation in rhyming couplets when it passes from isn't to is, wonders aloud whether neuropore formation is the beginning of cognition, and pens an ode to its placenta. Genetic variation engenders “Will I be … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif
Ischemia of the dog heart induces the appearance of a cardiac mRNA coding for a protein with migration characteristics similar to heat-shock/stress protein 71.
Authors: W H Dillmann, H B Mehta, A Barrieux, B D Guth, W E Neeley, J Ross
Journal: Circulation Research (1986)

Recent evidence indicates that different forms of stress, including hypoxia, can induce specific proteins called heat-shock or stress proteins in various types of mammalian cells. These studies examined whether myocardial ischemia can result in increased levels of proteins with molecular weight and isoelectric point characteristics similar to those described for heat-shock or stress proteins. The left anterior descending coronary artery of the dog heart was completely occluded; normal and ischemic myocardial samples were obtained 6 hours after occlusion; and total cardiac proteins and RNA were prepared. Ribonucleic acid was translated in vitro in a modified rabbit reticulocyte lysate system, and [35S]-methionine-labelled translational products as well as unlabelled cardiac proteins were separated by two-dimensional gel electrophoresis. Total proteins were visualized by silver staining and in vitro translation products quantified by fluorometry. A translatable mRNA coding for a 71,000 dalton peptide with an isoelectric point of 5.8 was markedly increased in the ischemic myocardium after 6 hours of ischemia. A protein with similar migration characteristics was detected in ischemic myocardium but not in normal myocardium. These results indicate that an mRNA coding for a translational product with similar migration characteristics of heat-shock protein 71 is induced by ischemia in the dog heart.
Immunoglobulin in Clinically Uninvolved Skin in Systemic Lupus Erythematosus ASSOCIATION WITH RENAL DISEASE
Authors: James N. Gilliam, Don E. Cheatum, Eric R. Hurd, Peter Stastny, Morris Ziff
Journal: Journal of Clinical Investigation (1974)

23 of 42, or 55%, of patients with systemic lupus erythematous had immunoglobulin deposits along the epidermal basement membrane of uninvolved skin (positive lupus band test [LBT]). In patients with low serum complement levels, 91% had a positive LBT), as compared with 15% in those with normal complement levels. The LBT was positive in 70% of patients with clinical and laboratory evidence of renal disease, but in only 31% of patients without renal disease. 81% of patients with the more severe histologic forms of lupus nephritis, i.e., proliferative glomerulonephritis and membranous glomerulonephritis, and positive tests, whereas only 23% with mesangial glomerulitis or normal histologic findings were positive. Immunoglobulins of the same class found in the skin were detected in the glomeruli of patients examined by renal biopsy. These results suggest that there is a relationship between the occurrence of immunoglobulin in the epidermal basement membrane and the presence of the more severe forms of lupus nephritis.
Three Bs, please
Authors: D. Spence
Journal: BMJ (2006)

“If you've got any grade As at A level you shouldn't be allowed to do medicine. All you get is the neurotics or the ‘gifted’ no-social-skills types. I would shoot all those sods on admission panels.” He glanced at me, and I nodded my approval.

I like drunken conversations. The self congratulation, back slapping, and unquestioned certainty of new political manifestos—for a few hours the world does seem brighter—until reality shakes you awake demanding breakfast.

How should …
Still Needed: A National Academy of Medicine
Authors: George D. Lundberg
Journal: JAMA (1988)

Whether Irvine Page is correct in his view that the Institute of Medicine (IOM) was set up improperly at the beginning<sup>1</sup>and was thus unlikely ever to work well or whether Sam Thier is correct in his view that the postadolescent IOM is beginning to get it together,<sup>2</sup>the fact remains that as of 1988 the United States needs, and has not had, a national academy of medicine that works. In the preceding article, Dr Page summarizes the nine functions that he and Dr James Shannon believed would be central to the mission of a national academy of medicine. They included making optimal technological choices in public policy, addressing problems through collegial efforts with other organizations, providing information on complicated issues to the press and public, restoring self-respect and public trust in medicine, conveying information between the public and the profession, explaining needs of medical education and research
Screening for abdominal aortic aneurysm
Authors: Paul S Frame
Journal: BMJ (2004)

Its time has come 

Abdominal aortic aneurysm (AAA) has intuitively seemed an ideal candidate for detection by screening for many years. It is a common condition, especially in older men, has a long asymptomatic period of development, and is accurately detected by ultrasound. Treatment prior to rupture is certainly better than waiting till symptoms, often a fatal rupture, occur. However, routine population screening for AAA has not been recommended by major groups in the United States. In 1996 the United States Preventive Services Task Force (USPSTF) stated, “There is insufficient evidence to recommend for or against routine screening of asymptomatic adults for abdominal aortic aneurysm with abdominal palpation or ultrasound.”1

Concerns about screening for AAA expressed by the USPSTF in 1996 included the lack of randomized controlled trials with mortality outcomes, uncertainty about the natural history and management of small aneurysms, and concerns about the high surgical mortality associated with elective repair. Many of these questions have recently been answered.

The Multicentre Aneurysm Screening Study (MASS),2 published in 2002, was a large randomized controlled trial of ultrasound screening for AAA in men aged 65 to 74, conducted in the United Kingdom. In this trial, death due …
Effects of a 24-week exercise programme on normal adults and patients with previous myocardial infarction.
Authors: P. A. Rechnitzer, M. S. Yuhasz, H. A. Pickard, N. Lefcoe, A. Paivio
Journal: BMJ (1967)

Several studies have suggested a relation between coronary artery disease and physical exercise. Animal experiments have failed to show a clear relation between the development of diet induced atherosclerosis and physical activity. Kobernick et al. (1957) showed that rabbits on an atherogenic diet developed less atherosclerosis after 13 weeks of exercise on a rotating drum than a non-exercised group. Brainard (1959) failed to rifirm these results. Evidence for a positive relation between physical activity and the development of coronary collateral circulation in both animals and man is somewhat more convincing (Eckstein, 1957 ; Stevenson et al., 1964). A gradual increase in physical activity is an important part of the rehabilitation of postinfarction patients, and they are now encouraged to resume their former activities. In a previous report the effects of a graduated exercise programme on a group of four patients with previous myocardial infarction were described (Rechnitzer et al., 1965). The present study surveys in greater detail some of the changes which occurred in four groups of men after a 24-week exercise programme.
An Address on American Methods in Medical Education
Authors: A. MacPhail
Journal: BMJ (1927)

ST'FPRTEL'REE: Dans cet HUtel-Dieu, cet h6pital de Dieu, le fover de la m6decine au Canada, il y a trois siecles, sanctifie palr la d6votion de vos sceurs et par la memoire dle Jeanne Mance, il peut se faire que l'esprit de ce milieu deseende suir nous.Sous l'influence de cet esprit 11o0us pourr-ions d6eouvrir que la nature n'est qu'une expressioni casuelle de la volonte divine; quoe l'etre idecal sulit l'ordre de la niature, et vit en accorrd avec cette volonte; que le malade a failli,-corps ot ame.Tout cc moderne ta'tonne- menit sioentifique pour tr-ouver 1'effet de l'ame malade sur le colrps iralade n'est que l'effort pour' decouvrir le secret que V3oU.n'avez jamais perdu, le pouvoir de la religion.C'est iun effort pouir r6pondre a la question du Maitre:
Abstract 4616: Oncogenic c- and N-Myc disrupt circadian rhythm.
Authors: Brian J. Altman, Annie Hsieh, Arvin Gouw, Anand Venkataraman, Bo Li, David Bellovin, M. Celeste Simon, Dean Felsher, John Hogenesch, Chi V. Dang
Journal: Cancer Research (2013)

Abstract Circadian rhythms are regulated by feedback loops comprising a network of factors that regulate Clock-associated genes. Chronotherapy seeks to take advantage of altered circadian rhythms in some cancers to better time administration of treatments to increase efficacy and reduce toxicity. Taking advantage of cancers that have substantially different circadian rhythms, or are ‘out of phase’, with normal tissues, could open a wide therapeutic window to make them vulnerable to chemotherapy or targeted drugs at different times than normal tissue. However, there is currently no basis to identify which cancers have disrupted circadian rhythms and would be amenable to chronotherapy. c- and N-Myc are oncogenic transcription factors translocated or amplified in many cancers. While the role of Myc in circadian rhythm is currently unknown, it may affect circadian rhythm by binding to the same E-box promoter regions used by the central regulators of circadian rhythm, Clock/Bmal1. Additionally, Myc increases NAD+ levels through upregulation of NAMPT, and NAD+ is a crucial cofactor in the activity of the circadian regulator Sirt1. Thus, we hypothesized that Myc may disrupt circadian rhythm through two mechanisms: inappropriate engagement of E-box promoters and also upregulation of NAMPT leading to dysregulated Sirt1 activity. Here we show in neuroblastoma, osteosarcoma, and hepatocellular carcinoma cells that overexpressed Myc specifically upregulated the negative circadian regulator Rev-erbα, which in turn decreased expression of Bmal1. Inhibition of NAMPT downstream of Myc upregulation also led to major perturbations in circadian gene expression, suggesting a role for NAD modulation downstream of Myc in disruption of circadian rhythm. Importantly, My-expressing cells showed dramatically disrupted circadian oscillations, which could be partially rescued by inhibiting expression of Rev-erbα. Together, these data suggest that Myc-driven cancers have altered circadian oscillation due to upregulation of Rev-erbα and NAMPT, and that cancers driven by Myc may thus be good candidates for chronotherapy. We thank the following funding sources: NIH R01CA051497, R01CA57341, LLS 636311 Citation Format: Brian J. Altman, Annie Hsieh, Arvin Gouw, Anand Venkataraman, Bo Li, David Bellovin, M. Celeste Simon, Dean Felsher, John Hogenesch, Chi V. Dang. Oncogenic c- and N-Myc disrupt circadian rhythm. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4616. doi:10.1158/1538-7445.AM2013-4616
A CASE OF EXTRA-UTERINE RETRO-PERITONEAL, PREGNANCY IN THE SEVENTH MONTH.Read before the Chicago Gynecological Society, December 19, 1890.
Authors: W. W. JAGGARD
Journal: JAMA (1891)

As my contribution to this evening's discussion, I beg to report a case of extra-uterine, retroperitoneal pregnancy that is especially noteworthy on account of its clinical course, anatomy, diagnosis, and treatment. <i>History</i>(Dr. Fitch C. E. Mattison).—Mrs. L. S., 36 years 6 months old, born in Altenberg, Saxony, coachman's wife; 5 feet 3 inches in height, 130 pounds in weight. Family history good; mother living, father died from septicaemia following injury to the hand. Married two years ago (September 23, 1888. Date of commencement of last menstruation, April 15, 1890; first pregnancy. Course of early pregnancy distinctly abnormal; patient said she was in bed at least three days out of the seven from pain and weakness. Dr. Fitch first saw the patient September 23, 9:30 a.m., when he found a woman, with a large abdominal tumor, in a condition closely bordering on collapse. She was cold, pallid, nearly pulse less,
Guillain-Barre Syndrome Following Smallpox Vaccination
Authors: Alexander L. Kisch
Journal: New England Journal of Medicine (1958)

JENNERIAN vaccination has for many years been a widely practiced procedure, with few complicating sequelae. The usual complication consists of painful local inflammation with regional lymphadenopathy and fever, but occasionally Kaposi's varicelliform eruption and acute disseminated encephalomyelitis occur.1 It is the purpose of this paper to report a case in which smallpox prophylaxis was followed by the development of the Guillain-Barré syndrome. A review of the literature reveals that this complication has been described only twice previously.2 , 3 Recent experimental work suggests that the occurrence of this type of polyradiculoneuropathy may have an immunologic basis.4 This case appears to lend clinical . . .
Clinical Trial of New Dressing for Varicose Ulcers
Authors: A. Standeven
Journal: BMJ (1958)

AMNION CELL CULTURESJcBRff L and is briefly compared with methods already reported.It is not claimed to be superior to others, but has been found to need [ittle attention, is not too long, and is generally successful.Thanks are due to the Sister Tutor and staff of the Queen