tbuckley/cabot-search huggingface dataset:
Adequate Ventilation with Acupuncture Anesthesia?
Authors: STANLEY J. BODNER
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 June 1973Adequate Ventilation with Acupuncture Anesthesia?STANLEY J. BODNERSTANLEY J. BODNERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-6-975 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: With an eye to the East, a surge of interest in Oriental medical techniques is appearing in the West. Even so, Dr. Cheng's description (Ann Intern Med 78:285-290, 1973) of thoracic surgery using acupuncture anesthesia leaves me breathless. Could Dr. Cheng or any of his cardiology colleagues, either at the Thoracic Hospital in Shanghai or at the George Washington University Medical Center in Washington, explain what force, during thoracotomy, keeps the patient's lungs inflated?The vivid illustration of a patient eating mandarin oranges during open thoracotomy seems impossible....References1. CHENG T: Other China medical advances transcend use of acupuncture. Intern Med News vol. 5, no. 20, 1972, pp. 1-32 Google Scholar2. CHENG T: Mitral commissurotomy under acupunctural anesthesia. Chronic Dis Management vol. 6, no. 12, 1972, p. 1 Google Scholar3. CHENG T: Medicine in modern China. J Am Geriatr Soc. In press Google Scholar4. CHENG T: Acupuncture anesthesia (letter). Science 179:521, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: MC USNR Naval Hospital Key West, Florida PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1973Volume 78, Issue 6Page: 975-976KeywordsAcupunctureAnesthesiaEatingLungsThoracic surgeryThoracotomy Issue Published: 1 June 1973 PDF downloadLoading ...
Population control and uncertainty--a doctor's role
Authors: F. Godlee
Journal: BMJ (2008)

Several readers have pointed out that the BMJ ’s recent coverage of climate change has ignored a key issue—the need for population control. John Guillebaud and Pip Hayes give the same rebuke in their editorial this week (doi: 10.1136/bmj.a576). They may be right that “population” and “family planning” are taboo words. The BMJ hasn’t actively avoided these issues, but we could do more to highlight them. As Guillebaud and Hayes portray it, every week an extra 1.5 million people need food and somewhere to live, amounting to “a huge new city each week, …
Total sialic acid in human and canine platelets does not change with the platelet age
Authors: Diego Mezzano, Eduardo Aranda, María Eugenia García, Jaime Pereira, Teresa Quiroga, Marcos Pérez
Journal: American Journal of Hematology (1992)

Total platelet sialic acid (SA) was measured in three experimental conditions: (1) human and canine platelet density subpopulations obtained by centrifugation in arabinogalactan gradients, (2) circulating canine platelets during recovery from experimental immune and mechanical thrombocytopenias, and (3) platelets obtained from a patient with chronic immune thrombocytopenic purpura before and after splenectomy. The density of human and canine platelets is, in part, determined by their age. We found no significant differences in total SA between high-density (HD) and low-density (LD) platelets (9.32 +/- 2.0 vs. 9.55 +/- 1.3 micrograms/mg of platelet protein in dogs and 9.02 +/- 2.3 vs. 9.10 +/- 2.9 micrograms/mg in humans). In the human and canine thrombocytopenic models, the entrance of new platelets from the bone marrow is followed by their aging in the circulation. In these models, no significant changes in total SA content were detected in sequential measurements during the recovery of the thrombocytopenia. Accordingly, we conclude that total SA in human and canine platelets is unrelated to their age in circulation. These results do not support the notion that the loss of SA from membrane glycoproteins determines the recognition and removal of platelets from the circulation.
Surgical masks were noninferior to N95 respirators for preventing influenza in health care providers
Authors: Lewis J. Radonovich
Journal: Annals of Internal Medicine (2010)

ACP Journal Club16 March 2010Surgical masks were noninferior to N95 respirators for preventing influenza in health care providersLewis J. Radonovich, MD, Bradley S. Bender, MDLewis J. Radonovich, MDMalcom Randall VA Medical Center, Gainesville, Florida, USA (L.J.R., B.S.B.)Search for more papers by this author, Bradley S. Bender, MDMalcom Randall VA Medical Center, Gainesville, Florida, USA (L.J.R., B.S.B.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-6-201003160-02002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationLoeb M, Dafoe N, Mahony J, et al. Surgical mask vs N95 respirator for preventing influenza among health care workers: a randomized trial. JAMA. 2009;302:1865-71. https://pubmed.ncbi.nlm.nih.gov/19797474Clinical Impact RatingsEmergency Med: Hospitalists: Infectious Disease: References1 Interim guidance on infection control measures for 2009 H1N1 influenza in healthcare settings, including protection of healthcare personnel. www.flu.gov/professional/hospital/infectioncontrolguidance.html (accessed 19 Jan 10). Google Scholar2 Lange S, Freitag G. Choice of delta: requirements and reality—results of a systematic review. Biom J. 2005;47:12-27. [PMID: 16395993] Google Scholar3 Shine KI, Rogers B, Goldfrank LR. Novel H1N1 influenza and respiratory protection for health care workers. N Engl J Med. 2009;361:1823-5. [PMID: 19797278] Google Scholar Author, Article, and Disclosure InformationAffiliations: Malcom Randall VA Medical Center, Gainesville, Florida, USA (L.J.R., B.S.B.)This article was published at Annals.org on 2 March 2010. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEpidemiology and Control: Principles, Practice and ProgramsFacemask Use by Children During Infectious Disease Outbreaks 16 March 2010Volume 152, Issue 6Page: JC3-2KeywordsHealth care providersPolymerase chain reactionPrevention, policy, and public healthPulmonary diseasesResearch laboratoriesRespiratorsTemperatureUpper respiratory tract infections ePublished: 16 March 2010 Issue Published: 16 March 2010 CopyrightCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Hodgkin disease: An analysis of 128 cases
Authors: Ramesh Dawar, Aroop Mangalik
Journal: American Journal of Hematology (1978)

An analysis of 128 cases of Hodgkin disease seen at the Department of Pathology, All India Institute of Medical Sciences, New Delhi, during the period 1968--1974 is presented with reference to histopathological and clinical findings. A male preponderance is noted in all age groups, and this is most noticeable in children under 15 years of age. There is a predominance of cases with the histologic subtypes associated with a poor prognosis (mixed cellularity and lymphocyte depleted). Only nine cases of nodular sclerosis type were seen.
Provocation of Hypotension During Head-Up Tilt Testing in Subjects With No History of Syncope or Presyncope
Authors: Andrea Natale, Masood Akhtar, Mohammad Jazayeri, Anwer Dhala, Zalmen Blanck, Sanjay Deshpande, Anita Krebs, Jasbir S. Sra
Journal: Circulation (1995)

Head-up tilt test is increasingly being used to evaluate patients with syncope. This study was designed to evaluate the specificity of head-up tilt testing using different tilt angles and isoproterenol infusion doses in normal volunteers with no prior history of syncope or presyncope.One hundred fifty volunteers were randomized to two groups of 75 each. In group 1, subjects were further randomized to have head-up tilt testing at a 60, 70, or 80 degree angle at baseline followed by repeat tilt testing during a low-dose isoproterenol infusion that increased the heart rate by an average of 20%. In group 2, after having a baseline head-up tilt test at a 70 degree angle for a maximum of 20 minutes, subjects were randomized to have a repeat tilt table testing at a 70 degree angle during a low-dose, 3 micrograms/min, or 5 micrograms/min isoproterenol infusion. In group 1, syncope or presyncope along with hypotension developed in 2 subjects during the baseline test at 60 and 70 degrees of tilt and in 5 subjects during tilting at 80 degrees. The addition of low-dose isoproterenol reduced the specificity minimally from 92% to 88% at both 60 and 70 degrees of tilt but substantially to 60% at an 80 degrees angle. However, 6 of the 10 subjects with a positive test at an 80 degree angle had an abnormal response after 10 minutes of tilt testing. In group 2, using various isoproterenol doses with tilt table testing at a 70 degree angle, low-dose (mean infusion dose, 1.5 +/- 0.45 microgram/min), 3 micrograms/min, and 5 micrograms/min isoproterenol infusions elicited an abnormal response in 1 (4%), 5 (20%), and 14 (56%) of the subjects, respectively. Using multiple logistic regression analysis, head-up tilt testing at an 80 degree angle (P = .01) or during 3 micrograms/min (P = .02) and 5 micrograms/min isoproterenol infusion rates (P < .001) was the most significant predictor of an abnormal response.Head-up tilt testing at a 60 or 70 degree angle with or without low-dose isoproterenol infusion provides an adequate specificity. Caution is needed, however, in interpreting the results if the head-up tilt test at 80 degrees is extended beyond 10 minutes or if high doses of isoproterenol are used.
FDG Uptake in Cutaneous and Subcutaneous Metastases From Colorectal Adenocarcinoma
Authors: In Young Hyun, Min-Young Yun
Journal: Clinical Nuclear Medicine (2010)

Cutaneous metastases from colorectal adenocarcinoma are rare, and it implies a poor prognosis. Early detection and recognition of the metastatic disease to the skin can dramatically alter the treatment and the prognosis of the disease. We described an unusual case of colorectal cancer with cutaneous metastases. In this case, FDG PET/CT revealed the abnormal focal uptake in a subcutaneous lump on the right abdominal wall 14 months after right hemicolectomy, and it was the sole site of abnormal FDG uptake. Wide excision of abdominal skin was performed. Histopathologic findings were metastatic adenocarcinoma from the colon.
Deletions of the transcription factor Ikaros in myeloproliferative neoplasms
Authors: R Jäger, H Gisslinger, F Passamonti, E Rumi, T Berg, B Gisslinger, D Pietra, A Harutyunyan, T Klampfl, D Olcaydu, M Cazzola, R Kralovics
Journal: Leukemia (2010)
The Heritage of the Radical Neck Dissection
Authors: Bobby R. Alford
Journal: JAMA (1987)

THE SUCCESS of the modern head and neck oncological surgeon in curing patients with head and neck cancer is due in large part to the principles that evolved from the astute clinical observations of George Crile, MD, and the truly imaginative and bold surgical concepts that he fostered. In his monumental article published in<i>JAMA</i>in 1906, he demonstrated the effectiveness of en bloc resection of regional lymph nodes and other lymphatic structures in the neck, including resection of the sternocleidomastoid muscle, the internal jugular vein, and the submaxillary salivary gland, in rendering patients free of disease. What led Crile to the surgical concepts he advocated was his observation that patients with head and neck cancer died primarily because the site of origin of the tumor was not controlled and/or the cancer had spread to regional neck structures. His basic premise was that each patient with cancer of the head
Regulation of Gluconeogenesis by Krüppel-like Factor 15
Authors: Susan Gray, Baiqiu Wang, Yvette Orihuela, Eun-Gyoung Hong, Sudeshna Fisch, Saptarsi Haldar, Gary W. Cline, Jason K. Kim, Odile D. Peroni, Barbara B. Kahn, Mukesh K. Jain
Journal: Cell Metabolism (2007)
Tropical Pulmonary Eosinophilia in a West African
Authors: J. A. McFadzean
Journal: BMJ (1955)

from cloudy swelling to necrosis.Medulla: A similar degeneration of the straight tubules, many of which con- tained blood casts.The vessels showed some thickening, chiefly of the muscle coats.Liver.-2,000 g.Flabby, yellow, and fatty.The cells were irregular in size and shape and were separated by spaces.No cirrhosis or congestion was seen.In the portal areas the vessels and ducts appeared thickened, with loose fibrous tissue rather irregularly disposed.Some lymphocytic infiltration was also present in these areas.Pathological
Scientists harvest stem cells from blastocysts created by parthenogenesis
Authors: O. Dyer
Journal: BMJ (2003)

Scientists from the US biotechnology company Stemron have managed to obtain stem cells from eggs that they have grown into blastocysts by a process of parthenogenesis. The procedure could provide an alternative source of stem cells for research, since using stem cells from human embryos is banned in the United States.

While insect …
The Fletcher Editorship: A Legacy of Achievement
Authors: John H. Holbrook
Journal: Annals of Internal Medicine (1993)

Editorials15 December 1993The Fletcher Editorship: A Legacy of AchievementJohn H. Holbrook, MDJohn H. Holbrook, MDPublication Policy Committee, American College of Physicians.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-12-199312150-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Robert and Suzanne Fletcher will leave their positions as Editors of Annals at the end of 1993. Their departure is a loss for the College and for the readers of Annals. They will be missed and fondly remembered as they begin new careers at Harvard Medical School.The Fletchers came to the College in July of 1990 to assume the seventh editorship of Annals. As practicing internists and distinguished academicians, they have taken the leading specialty journal in the world to new levels of excellence. During their tenure, the circulation of Annals first topped 100 000. Many of their accomplishments ...REFERENCE1. Fletcher RH, Fletcher SW. A transition. Ann Intern Med. 1990; 113: 6-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: Publication Policy Committee, American College of Physicians.Corresponding Author: John H. Holbrook, MD, Division of General Medicine, University of Utah Medical Center, 50 North Lake Shore Drive, Salt Lake City, UT 84132 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1993Volume 119, Issue 12Page: 1221KeywordsComputersDrugsMedical educationPatientsPeer review Issue Published: 15 December 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Geriatrics, Prevention, and the Remodeling of Medicare
Authors: John W. Rowe
Journal: New England Journal of Medicine (1999)

Geriatric medicine has focused primarily on the management of acute and chronic diseases in frail older persons, with much less emphasis on the promotion of health and the prevention of disease than there is in health care for children or middle-aged adults. A growing body of knowledge about disease prevention in later life, including important research by Inouye et al.1 that is reported in this issue of the Journal, provides a valid basis for strengthening efforts in preventive geriatrics. Given its mission and responsibility, the Medicare program is well positioned to lead such an effort on a national level.Inouye . . .
Avulsive Cortical Irregularity and F-18 FDG PET
Authors: Susan A. Connolly, Kimberly J. Davies, Leonard P. Connolly
Journal: Clinical Nuclear Medicine (2006)

F-18 FDG PET showed marked uptake in the posteromedial left distal femoral metaphysis of a 9-year-old boy whose history of trilateral retinoblastoma indicated a high risk of additional malignancies, including osteosarcoma. Evaluation with radiographs and MRI revealed that an avulsive cortical irregularity was the cause of the high uptake. Because avulsive cortical irregularities are common in the distal femur between 3 and 17 years of age, recognition of the potential for high F-18 FDG uptake is important in interpreting PET of children and adolescents.
High-throughput Screening and Biophysical Interrogation of Hepatotropic AAV
Authors: Samuel L Murphy, Anand Bhagwat, Shyrie Edmonson, Shangzhen Zhou, Katherine A High
Journal: Molecular Therapy (2008)

We set out to analyze the fundamental biological differences between AAV2 and AAV8 that may contribute to their different performances in vivo. High-throughput protein interaction screens were used to identify binding partners for each serotype. Of the >8,000 proteins probed, 115 and 134 proteins were identified that interact with AAV2 and AAV8, respectively. Notably, 76 of these protein interactions were shared between the two serotypes. CDK2/cyclinA kinase was identified as a binding partner for both serotypes in the screen. Subsequent analysis confirmed direct binding of CDK2/cyclinA by AAV2 and AAV8. Inhibition of CDK2/cyclinA resulted in increased levels of vector transduction. Biophysical study of vector particle stability and genome uncoating demonstrated slightly greater thermostability for AAV8 than for AAV2. Heat-induced genome uncoating occurred at the same temperature as particle degradation, suggesting that these two processes may be intrinsically related for adeno-associated virus (AAV). Together, these analyses provide insight into commonalities and divergences in the biology of functionally distinct hepatotropic AAV serotypes.
The FIP1-like-1 (FIP1L1)- Platelet-Derived Growth Factor Receptor Alpha (PDGFR alpha) fusion gene cooperates with IL-5 to induce a hypereosinophilic syndrome (HES)-like disease in a murine model
Authors: Y. Yamada, M.E. Rothenberg, A.W. Lee, H. Saito-Akei, E.B. Brandt, D.A. Williams, J.A. Cancelas
Journal: Journal of Allergy and Clinical Immunology (2005)
Cancer Research: Impact of the Cooperative Groups
Authors: David T. Carr
Journal: JAMA (1981)

Santayana wrote, "Those who cannot remember the past are condemned to repeat it." According to the editor of this book, which has 82 contributors it was "written to review the accomplishments of the Clinical Cooperative Groups during the past 25 years." Most of these 82 contributors, not only "remember the past," but they were active participants in the development of the clinical cooperative groups. As many of today's participants in the ongoing clinical cooperative studies in cancer have entered the field too recently to "remember the past," this publication should be required reading for them. There are chapters for each of the more important primary sites of cancer, and separate chapters for the contributions of various disciplines. Of special interest are chapters on the relationships between the cooperative groups and basic research in cancer and cancer education. The relationships and conflicts between the groups, the National Cancer Institute, the cancer
Soft Bones, Hard Facts and Calcitonin Therapy
Authors: Armen H. Tashjian
Journal: New England Journal of Medicine (1970)

Calcitonin is a polypeptide — probably a hormone — isolated from the thyroid gland or ultimobranchial body of a wide variety of species ranging from the Pacific salmon to man. In all examples that have been studied to date, the peptide contains 32 amino acid residues with a characteristic amino terminal disulfide ring and prolinamide at the carboxyl terminus, but with many differences in individual amino acids along the mid-portion of the chain.1 , 2 The most widely recognized biologic actions of calcitonin are its hypocalcemic and hypophosphatemic effects.1 , 3 These appear to result from a direct, rapid and transient inhibitory action on . . .
THE USE OF BENZYL BENZOATE IN THE TREATMENT OF ANGINA PECTORIS
Authors: ROBERT H. BABCOCK
Journal: JAMA (1924)

I shall make no attempt to give the literature pertaining to the use and action of this particular benzyl ester further than to say that its mode of action, as pointed out by Macht, is to relieve spasm due to contraction of smooth muscle fiber. Hence it has been employed largely in cases of renal colic and of bronchial asthma. So far as I know, the only article dealing with its use in angina pectoris is a paper by Dr. A. B. Spach<sup>1</sup>of Chicago. In that paper the author reported six cases in which more or less complete relief followed the administration of the remedy. In one of them the blood pressure was low, 100 systolic, whereas, in the others, varying degrees of hypertension existed. My attention was first called to the use of benzyl benzoate in Heberden's angina by my office associate, Dr. Bayard Holmes, Jr., who
Response to Nicolich
Authors: Alan H. Lockwood
Journal: Diabetes Care (2002)

In a previous letter (1), I identified a significant correlation between the statewide prevalence of diabetes and air releases of toxicants reported in the Toxics Release Inventory (TRI) report (available from www.epa.gov/tri). Although I suggested a possible mechanism for this link, related to dioxins, I was careful to note that correlations do not prove cause-and-effect relationships. Dr. Nicolich expands on that point in his letter (2).

A coincidence is a “striking occurrence of two events at one time apparently by mere chance” (3). I would agree that it is a virtual certainty that …
The HIV Epidemic and Training in Internal Medicine
Authors: M Cooke, M A Sande
Journal: New England Journal of Medicine (1989)

Since the acquired immunodeficiency syndrome (AIDS) was first described in 1981, thousands of papers have been written on all aspects of the disease, from basic virology through social psychology. With few exceptions,1 , 2 however, little has been said about the effect of AIDS on medical education. This paper considers several levels at which the human immunodeficiency virus (HIV) epidemic poses a challenge to medical education and proposes a set of responses with which training programs in internal medicine can better incorporate and accommodate this new disease.Visible Issues"I'd just as soon not take the risk"Apprehension about the occupational transmission . . .
Mevalonic Aciduria Cured by Bone Marrow Transplantation
Authors: Peter D. Arkwright, Mario Abinun, Andrew J. Cant
Journal: New England Journal of Medicine (2007)

1 discuss the use of bone marrow transplantation in the treatment of severe mevalonic aciduria.We provide additional evidence for the effective cure of mevalonic aciduria by hematopoietic stem-cell transplantation.In February 2006, we performed hematopoietic stem-cell transplantation in an 8-year-old boy who had mevalonic aciduria associated with a polymorphism in the TNFRSF1A gene, using allogeneic bone marrow from a matched sibling.Details of the clinical features of the case and biochemical and genetic evidence for the diagnosis of the periodic fever syndrome have been reported previously. 2 The patient's severe febrile episodes, which had occurred on the average of every 1 to 2 months since infancy, were resistant to 4-to-6-month trials of treatment with highdose aspirin, prednisolone, cyclosporine, and anakinra.The use of subcutaneous etanercept led to only a temporary respite, lasting less than 6 months.However, in the 16 months since transplantation of bone marrow from an HLA-matched sister, our patient has had no further episodes of periodic fever.The patient is now well, with stable full donor chimerism (100%).Chronic, mild, graft-versushost disease (GVHD) limited to the skin is controlled with oral tacrolimus and topical corticosteroids.However, in contrast to the patient described by Neven et al., our patient had an