Sodium Fluoride in the Treatment of Osteoporosis and Other Bone Diseases
Authors: PETER H. ADAMS
Journal: Annals of Internal Medicine (1965)

Editorials1 December 1965Sodium Fluoride in the Treatment of Osteoporosis and Other Bone DiseasesPETER H. ADAMS, M.B., JENIFER JOWSEY, D.PHIL.PETER H. ADAMS, M.B.Search for more papers by this author, JENIFER JOWSEY, D.PHIL.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-6-1151 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a study of workers exposed to cryolite (sodium aluminum fluoride) dust for many years, Roholm (1) found that some had severe chronic skeletal fluorosis but that in a greater number there was radiologic evidence of osteosclerosis which was not associated with symptoms. This observation led Rich and Ensinck (2) to administer sodium fluoride to patients with rarefying disorders of the skeleton in the belief that the production of a mild degree of asymptomatic osteosclerosis would strengthen the bone. Since then, several investigators have reported their experiences with sodium fluoride therapy in patients with osteoporosis (3-5), osteitis deformans (3, 6,...References1. ROHOLM K: Fluorine Intoxication, A Clinical-Hygienic Study: With a Review of the Literature and Some Experimental Investigations. H. K. Lewis & Co., Ltd., London, 1937. 364 pages. Google Scholar2. RICHENSINCK CJ: Effect of sodium fluoride on calcium metabolism of human beings. Nature (London) 191: 184, 1961. CrossrefMedlineGoogle Scholar3. RICHENSINCKIVANOVICH CJP: The effects of sodium fluoride on calcium metabolism of subjects with metabolic bone diseases. J. Clin. Invest. 43: 545, 1964. CrossrefMedlineGoogle Scholar4. BERNSTEINGURICOHENCOLLINSTAMVAKOPOULOS DSCPJJS: The use of sodium fluoride in metabolic bone disease (Proceedings). J. Clin. Invest. 42: 916, 1963. Google Scholar5. COHENRUBINI MBME: The treatment of osteoporosis with sodium fluoride. Clin. Orthop. 40: 147, 1965. CrossrefMedlineGoogle Scholar6. 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J. Université de Liège, 1965, pp. 79-88. Google Scholar12. JOWSEYKELLYRIGGSBIANCOSCHOLZGERSHON-COHEN JPJBLAJDAJ: Quantitative microradiographic studies of normal and osteoporotic bone. J. Bone Joint Surg. 47-A: 785, 1965. CrossrefGoogle Scholar13. SCHRAERPOSNERSCHRAERZlPKIN HASRI: Effect of fluoride on bone "crystallinity" in the growing rat. Biochim. Biophys. Acta 64: 565, 1962. CrossrefMedlineGoogle Scholar14. GEALLBEILIN MGLJ: Sodium fluoride and optic neuritis. Brit. Med. J. 2: 355, 1964. CrossrefMedlineGoogle Scholar15. SORSBYHARDING AR: Experimental degeneration of the retina. V. Fasting and metabolic accelerators in degeneration produced by sodium fluoride. Brit. J. Ophthal. 44: 213, 1960. CrossrefMedlineGoogle Scholar16. SINGHJOLLYBANSALMATHUR ASSBCCC: Endemic fluorosis. Epidemiological, clinical and biochemical study of chronic fluorine intoxication in Panjab (India). Medicine (Balt.) 42: 229, 1963. CrossrefMedlineGoogle Scholar17. TAVESTERRYSMITHGARDNER DRRFADE: Use of fluoridated water in long-term hemodialysis. Arch. Intern. Med. (Chicago) 115: 167, 1965. CrossrefMedlineGoogle Scholar18. CALLGREENWOODLECHEMINANTSHUPENIELSENOLSONLAMBORNMANGELSONDAVIS RADAWHJLHMLEREFLRV: Histological and chemical studies in man on effects of fluoride. Public Health Rep. 80: 529, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Section of Surgical Research Mayo Clinic and Mayo Foundation Rochester, Minn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySeasonal Variation of Boron and Fluoride in Tilapia nilotica from an Egyptian Fish Farm in Relation to Human Health Hazard AssessmentThe effects of short-term fluoride ingestion on bone formation and resorption in the rat femurAPPENDIX IDistribution of the perilacunar hypomineralized areas in cortical bone from patients with familial hypophosphatemic (vitamin D-resistant) ricketsModifications of the perilacunar walls resulting from the effect of fluoride on osteocytic activityAspects of growth and bone structure in hypophosphataemic ricketsEffect of low calcium diet on bone and calcium metabolism in rats and mice—A differential species responsePhysical Properties and Chemical Content of Canine Femoral Cortical Bone in Nutritional Osteopenia its Reversibility and the Effect of FluorideThree Years' Experience with Sodium-Fluoride Therapy of OsteoporosisScanning electron microscopic observations on bone from patients with hypophosphataemic (vitamin D resistant) ricketsAbsorption and utilization in the rat of calcium and fluoride from compatible compoundsFluoride and boneThe effects of fluoride and low calcium on the physical properties of the rat femurTHE EUROPEAN SOCIETY FOR PAEDIATRIC ENDOCRINOLOGY59. Funktionelle Anpassung des Knochens auf physiologische und unphysiologische Beanspruchung Pathophysiologie und Behandlung der OsteoporoseThe Fluoride Content of Some Foods and Beverages?a Brief Survey Using a Modified Zr-SPADNS Method 1 December 1965Volume 63, Issue 6Page: 1151-1155KeywordsBoneDustOsteoporosisSkeletonSodium Issue Published: 1 December 1965 PDF DownloadLoading ...