The Acquired Immunodeficiency Syndrome and a Trimethoprim-Sulfamethoxazole Adverse Reaction
Authors: David L. Cohn, Kent A. Penley, Franklyn N. Judson, Charles H. Kirkpatrick, Charles R. Horsburgh, Kathleen C. Davis
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 February 1984The Acquired Immunodeficiency Syndrome and a Trimethoprim-Sulfamethoxazole Adverse ReactionDAVID L. COHN, M.D., KENT A. PENLEY, B.S., FRANKLYN N. JUDSON, M.D., CHARLES H. KIRKPATRICK, M.D., CHARLES R. HORSBURGH JR., M.D., KATHLEEN C. DAVIS, M.D.DAVID L. COHN, M.D.Search for more papers by this author, KENT A. PENLEY, B.S.Search for more papers by this author, FRANKLYN N. JUDSON, M.D.Search for more papers by this author, CHARLES H. KIRKPATRICK, M.D.Search for more papers by this author, CHARLES R. HORSBURGH JR., M.D.Search for more papers by this author, KATHLEEN C. DAVIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-2-311_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A 31-year-old homosexual man was admitted to Denver General Hospital with Pneumocystis carinii pneumonia.The patient's T-cell helper-to-suppressor ratio was 0.19 (normal, greater than 1.0). In-vitro lymphocyte responses to concanavalin A and pokeweed mitogen were reduced; responses to phytohemagglutinin were normal, and those to purified protein derivative, Candida, and tetanus were absent. The Clq binding of circulating immune complexes was normal (4.8%). Immunoglobin A was elevated (725 mg/dL); IgG and IgM were normal.Intravenous trimethoprim-sulfamethoxazole, 240 and 1200 mg respectively every 6 hours, resulted in clinical and radiographic improvement but on the eighth day the patient had...References1. Drugs for parasitic infections. Med Lett Drugs Ther. 1982;24:5-12. MedlineGoogle Scholar2. WINSTONLAUGALEYOUNG DWRL. Trimethoprim-sulfamethoxazole for the treatment of Pneumocystis carinii pneumonia. Ann Intern Med. 1980;92:762-9. LinkGoogle Scholar3. JICK H. Adverse reactions to trimethoprim-sulfamethoxazole in hospitalized patients. Rev Infect Dis. 1982;4:426-8. CrossrefMedlineGoogle Scholar4. MITSUYASUGROOPMANVOLBERDING RJP. Cutaneous reaction to trimethoprim-sulfamethoxazole in patients with AIDS and Kaposi's sarcoma. N Engl J Med. 1983;308:1535-6. CrossrefMedlineGoogle Scholar5. FAUCI A. The syndrome of Kaposi's sarcoma and opportunistic infections: an epidemiologically restricted disorder of immunoregulation. Ann Intern Med. 1983;96:777-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAtypical Severe Shock-like Reactions in Adolescents After Trimethoprim-Sulfamethoxazole TherapyAnaphylactic-like reaction from trimethoprim-sulfamethoxazole in a patient with AIDSDrug ReactionsSuccessful Oral Desensitization to Trimethoprim-Sulfamethoxazole in Acquired Immune Deficiency SyndromeAllergic manifestations of human immunodeficiency virus (HIV) infectionHypoglycaemia and Diabetes Mellitus Following Parenteral Pentamidine Mesylate Treatment in AIDS PatientsReaction After Re-exposure to Trimethoprim-SulfamethoxazoleSevere Hypersensitivity Reaction upon Rechallenge with Trimethoprim-Sulfamethoxazole in a Patient with AIDSCO-TRIMOXAZOLE IN AIDSMiscellaneous antibacterial and antiviral drugsKAPOSI'S SARCOMA IN ZAMBIAACUTE HYPERSENSITIVITY REACTION TO CONTRAST MEDIA IN TWO HOMOSEXUALS WITH GENERALISED LYMPHADENOPATHY 1 February 1984Volume 100, Issue 2Page: 311-311KeywordsAIDSAdverse reactionsCandidaHomosexualsImmune complexLymphocytesPhytohemagglutininsPneumocystis carinii pneumoniaTetanusTuberculin Issue Published: 1 February 1984 PDF downloadLoading ...