Bone Marrow Transplantation: What Is the Question?
Authors: Nelson J. Chao
Journal: Annals of Internal Medicine (1990)

Editorials1 September 1990Bone Marrow Transplantation: What Is the Question?Nelson J. Chao, MD, Karl G. Blume, MDNelson J. Chao, MDSearch for more papers by this author, Karl G. Blume, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-5-340 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAllogeneic bone marrow transplantation is entering its third decade as a curative therapeutic modality for treating certain malignant and nonmalignant diseases. Some controversies still surround its use. One controversy pertains to the proper timing of marrow transplantation for the acute leukemias, specifically for acute lymphoblastic leukemia in the adult patient. The appropriate time to proceed to marrow transplantation depends on the stage of the disease.The use of modern combination chemotherapy in adults who have a relapse after their first remission is associated with a dismal prognosis; there are only a few anecdotal case reports of long-term, disease-free survival. In...References1. ThomasSandersFlournoy EJN. Marrow transplantation for patients with acute lymphoblastic leukemia: a long-term follow-up. Blood. 1983;62:1139-41. CrossrefMedlineGoogle Scholar2. DinsmoreKirkpatrickFlomenberg RDN. Allogeneic bone marrow transplantation for patients with acute lymphoblastic leukemia. Blood. 1983;62:381-8. CrossrefMedlineGoogle Scholar3. BlumeFormanKrance KSR. Bone marrow transplantation for acute leukemia. Haematol Blood Transf 1985;29:39-41. CrossrefMedlineGoogle Scholar4. WeisdorfNesbitRamsay DMN. 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Author, Article, and Disclosure InformationAffiliations: Stanford University School of Medicine Stanford, CA 94305 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCurrent status of allogeneic and autologous blood and marrow transplantation: Report from the IBMTR and ABMTR — North AmericaBone marrow transplantation for acute lymphoblastic leukemia(all)Allogeneic Bone Marrow Transplantation for the Treatment of Adult Acute LeukemiasChemotherapy Compared with Bone Marrow Transplantation for Adults with Acute Lymphoblastic Leukemia in First RemissionMary M. Horowitz, MD, Dorle Messerer, PhD, Dieter Hoelzer, MD, Robert Peter Gale, MD, PhD, Albrecht Neiss, PhD, Kerry Atkinson, MD, A. John Barrett, MD, Thomas Büchner, MD, Mathias Freund, MD, Gerhard Heil, MD, Wolfgang Hiddemann, MD, Hans-Jochem Kolb, MD, Helmut Löffler, MD, Alberto M. Marmont, MD, Georg Maschmeyer, MD, Alfred A. Rimm, PhD, Ciril Rozman, MD, Kathleen A. Sobocinski, MS, Bruno Speck, MD, Eckhard Thiel, MD, Daniel J. Weisdorf, MD, Ferry E. Zwaan, MD, PhD, Mortimer M. Bortin, MD 1 September 1990Volume 113, Issue 5Page: 340-341KeywordsBone marrowBone marrow transplantationCombination chemotherapyDisease free survivalLeukemiaPrecursor cellsTransplantation Issue Published: 1 September 1990 PDF DownloadLoading ...