Severe Hypersensitivity Associated with Clopidogrel
Authors: Françoise Sarrot-Reynauld, Laurence Bouillet, Jean-Luc Bourrain
Journal: Annals of Internal Medicine (2001)

Letters21 August 2001Severe Hypersensitivity Associated with ClopidogrelFrançoise Sarrot-Reynauld, MD, PhD, Laurence Bouillet, MD, and Jean-Luc Bourrain, MDFrançoise Sarrot-Reynauld, MD, PhDUniversity Hospital of Grenoble, F38043 Grenoble Cedex 9, France (Sarrot-Reynauld, Bouillet, Bourrain), Laurence Bouillet, MDUniversity Hospital of Grenoble, F38043 Grenoble Cedex 9, France (Sarrot-Reynauld, Bouillet, Bourrain), and Jean-Luc Bourrain, MDUniversity Hospital of Grenoble, F38043 Grenoble Cedex 9, France (Sarrot-Reynauld, Bouillet, Bourrain)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-4-200108210-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Clopidogrel, an antiplatelet agent, is used to prevent thrombotic complications of atherosclerosis (1, 2). Various trials found that its tolerability is similar to that of aspirin (3). Since 1998, more than 4.7 million patients throughout the world have been treated with this drug. Although rare, some reactions to clopidogrel have been described (4, 5). We report a case of hypersensitivity associated with clopidogrel.After a myocardial infarction, a 57-year-old man received clopidogrel, 75 mg/d. On day 5 of treatment, he developed fever, rash, pruritus, and abdominal pain. Three days later, he was hospitalized with shock, bilateral lung ...References1. CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet. 1996;348:1329-39. [PMID: 8918275] CrossrefMedlineGoogle Scholar2. Moussa I, Oetgen M, Roubin G, Colombo A, Wang X, Iyer S, et al . Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation. Circulation. 1999;99:2364-6. [PMID: 10318654] CrossrefMedlineGoogle Scholar3. Harker LA, Boissel JP, Pilgrim AJ, Gent M. Comparative safety and tolerability of clopidogrel and aspirin: results from CAPRIE. CAPRIE Steering Committee and InvestigatorsClopidogrel versus aspirin in patients at risk of ischaemic events. Drug Saf. 1999;21:325-35. [PMID: 10514023] CrossrefMedlineGoogle Scholar4. Tholl U, Anlauf M, Helmchen U. Clopidogrel and membranous nephropathy [Letter]. Lancet. 1999;354:1443-4. [PMID: 10543675] CrossrefMedlineGoogle Scholar5. Bennett CL, Connors JM, Carwile JM, Moake JL, Bell WR, Tarantolo SR, et al . Thrombotic thrombocytopenic purpura associated with clopidogrel. N Engl J Med. 2000;342:1773-7. [PMID: 108529992] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University Hospital of Grenoble, F38043 Grenoble Cedex 9, France (Sarrot-Reynauld, Bouillet, Bourrain) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClopidogrel-Induced Interstitial Lung Disease: A Case ReportA joint allergist/cardiologist classification for thienopyridines hypersensitivity reactions based on their symptomatic patterns and its impact on the management strategiesClopidogrelPrasugrel as alternative treatment strategy in a case with a hypersensitivity reaction to clopidogrelClopidogrel hypersensitivity: clinical challenges and options for managementÜberempfindlichkeits- und allergische Reaktionen auf hämostaseologisch wirksame MedikamenteAdverse immunological effects of drugs other than anticance drugs and drugs used in immunologyClopidogrel Hypersensitivity: A Novel Multi-Day Outpatient Oral Desensitization RegimenANTICOAGULANTS, THROMBOLYTIC AGENTS, AND ANTI-PLATELET DRUGSClopidogrel Desensitization: Case Report and Review of Published ProtocolsImmediate hypersensitivity and delayed hypersensitivity to ClopidogrelNoncardiogenic pulmonary edema associated with clopidogrel: A serious but unexpected side effect of clopidogrelClopidogrel Desensitization Protocol for the Treatment of Thienopyridine HypersensitivityRash with Both Clopidogrel and Ticlopidine in Two Patients Following Percutaneous Coronary Intervention with Drug-Eluting StentsClopidogrelClopidogrel-associated autoimmune thrombocytopenic purpuraClopidogrel-Induced Systemic Inflammatory Response SyndromeDrugs affecting blood coagulation, fibrinolysis, and hemostasisCurrent Awareness 21 August 2001Volume 135, Issue 4Page: 305-306KeywordsAminotransferasesBloodDrugsHypersensitivityLungsRashesShockSteroid therapyThoraxUltrasound imaging ePublished: 21 August 2001 Issue Published: 21 August 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...