tbuckley/cabot-search huggingface dataset:
Left Ventricular Function in Patients with Mitral Valve Prolapse A Radionuclide Evaluation
Authors: MASOOD AHMAD, HELMUT HAIBACH
Journal: Clinical Nuclear Medicine (1982)

Thirty patients with cineangiographically confirmed mitral valve prolapse (MVP) were studied by radionuclide angiography at rest and during exercise. Twelve patients had isolated MVP and 18 patients had associated coronary artery disease. All patients had normal resting left ventricular ejection fraction and wall motion. Of 18 patients with MVP and coronary artery disease, the left ventricular ejection fraction remained unchanged during exercise in 15 patients, decreased in two patients, and increased in one patient. Of 12 patients with MVP without associated coronary artery disease, ejection fraction increased during exercise in 6 patients, remained unchanged in 4 patients, and decreased in 2 patients. We conclude that an abnormal left ventricular function response during exercise does not always indicate the presence of coronary artery disease and may occur in patients with isolated MVP. Furthermore, the left ventricular dysfunction of patients with isolated MVP may be obvious only during exercise.
Ruptured Abdominal Aneurysm Occurring in Marfan's Syndrome
Authors: Creighton A. Hardin
Journal: New England Journal of Medicine (1959)

THE cardiovascular, skeletal and ocular manifestations of Marfan's syndrome have been well described in the literature.1 2 3 4 Dissecting or fusiform aneurysms are usually confined to the ascending aorta proximal to the innominate artery. The presence of fusiform aneurysms in the abdominal aorta has been reported as occurring in 2 cases.5 This paper reports such an abdominal aneurysm, which spontaneously ruptured, and the surgical attempt at resection and replacement of the aortic defect with a nylon prosthesis.Case ReportA 21-year-old man was admitted to the hospital on December 5, 1957, because of abdominal and back pain that had begun 24 hours . . .
X-RAY QUALITY AND SKIN REACTION.
Authors: GOTTWALD SCHWARZ
Journal: British Journal of Dermatology (1940)

Journal Article X‐RAY QUALITY AND SKIN REACTION. Get access GOTTWALD SCHWARZ, GOTTWALD SCHWARZ X‐Ray Department, Prince of Wales's General Hospital, London. (S. Cochrane Shanks) Search for other works by this author on: Oxford Academic Google Scholar Honorary Member of the American Roentgen Society. Honorary Member of the American Roentgen Society. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 52, Issue 1, 1 January 1940, Pages 10–20, https://doi.org/10.1111/j.1365-2133.1940.tb09891.x Published: 01 January 1940
RADIATION THERAPY IN MALIGNANT DISEASES OF THE THYROID GLAND
Authors: U. V. PORTMANN
Journal: JAMA (1927)

Our total series of cases of malignant diseases of the thyroid gland possibly includes 210 cases. Of these, however, ten cases have been classified as precancerous by the pathologists, and thirty-four are classified either as suspicious or as questionable, or have been under observation for too short a period to be included in this discussion. This report, therefore, is based on the observations in 166 cases of. malignant disease of the thyroid gland in which the diagnosis is not questioned. All these patients have lived more than one year since the diagnosis was made, or are dead; in those cases in which a microscopic examination of the growth has not been made, the clinical course has been typical of malignant disease. Of the 10,355 cases in our total series of cases of diseases of the thyroid gland in which operation or some other form of treatment has been carried out,
Abstract 5470: Potent MEK inhibitor CIP-137401: Preclinical studies
Authors: Uday R. Khire, Ajay Bhargava, Barry Hart, Mahendra D. Chordia
Journal: Cancer Research (2011)

Abstract In recent years there is a lot of interest in both pre-clinical and clinical setting for the development of MEK kinase inhibitors as therapeutic agents for various cancers. A quite few number of MEK kianse inhibitors are currently undergoing phase I/II clinical trials both as a single agent as well as a combination with variety of other anti-tumor agents. These single agents include AZD-6244, RDEA-119, GSK-1120212, AS-703026 etc. One of the factors favoring MEK kinase as a sought after target besides being a part of very relevant Ras-Raf-MEK-ERK pathway is the identification of an allosteric binding site, which provides excellent selectivity for MEK kinase inhibitors as a class. Constitutive activation of Ras-Raf-MEK-ERK pathway has been a hallmark in several cancer types, including pancreatic, colon, lung, and melanoma. MEK is selective in phosphorylating serine/threonine residues of proteins resulting in regulation of variety of physiological functions of the cell including apoptosis, differentiation, proliferation and gene expression. We recently discovered a novel, potent, non-ATP competitive, allosteric class of MEK kinase inhibitors. Our lead compound, CIP-1374, in the preliminary in vitro data that include primary enzyme assay, inhibition of ERK phophorylation, and anti-proliferation assays in various cell lines exhibited very potent activity. CIP-1374 also displayed excellent pharmaco-kinetic profile in mice with about 17h of half life with about 30% oral bioavailability. Another molecule in this series, CIP-137401 is also displaying a potent in vitro activity in various assays. We are currently focusing on CIP-137401 as our lead candidate and conducting preclinical studies. In this poster, our results in preclinical studies including rat pharmaco-kinetic, metabolic stability, and in-vitro toxicology data will be presented. The in vitro toxicology assays include its profiling in cardiac toxicity data (hERG channel activation). In addition the efficacy data from in vivo tumor xenograft models will be presented. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5470. doi:10.1158/1538-7445.AM2011-5470
Pyogenic abscesses in the myelodysplastic syndrome.
Authors: P. J. Williamson, D. G. Oscier, G. J. Mufti, T. J. Hamblin
Journal: BMJ (1989)

7 observations d'abces importants chez des malades âges atteints de syndromes myelodysplasiques, sans neutropenie, ce qui pose des problemes de diagnostic
Combination Therapy with Zidovudine and Dideoxycytidine in Patients with Advanced Human Immunodeficiency Virus Infection
Authors: Tze-Chiang Meng, Margaret A. Fischl, Ahmad M. Boota, Stephen A. Spector, Donald Bennett, Yiannis Bassiakos, Shenghan Lai, Brian Wright, Douglas D. Richman
Journal: Annals of Internal Medicine (1992)

Objective: To evaluate the safety and immunologic and antiviral effects of combination therapy with zidovudine and dideoxycytidine (ddC) in patients with advanced human immunodeficiency virus type 1 (HIV) infection. Design: A phase I/II open-label, dose-ranging study. Setting: Two AIDS Clinical Trials Group units. Patients: Patients (56) with advanced HIV disease. Interventions: Patients were randomly assigned to one of three paired regimens of zidovudine and ddC. We evaluated six dosing regimens, each involving oral administration of the study drugs at 8-hour intervals. Measurements: Pharmacokinetics, toxicity, CD4 counts, p24 antigenemia and clinical end points. Main Results: The median follow-up period was 40.6 weeks (range, 0.3 to 70 weeks). Neither drug affected the pharmacokinetic profile of the other. Episodes of serious hematologic toxicity were infrequent, occurring in only 17.9% of patients, and did not differ among the regimens (P = 0.15). Severe sensory peripheral neuropathy occurred in two patients (one patient each in regimens 1 and 4). One patient receiving regimen 4 died. The mean maximal increase in CD4 counts exceeded 109 cells/mm3, and 69% of patients receiving combinations containing 300 or 600 mg of zidovudine daily had an increase in CD4 counts of 50 cells/mm3 or greater. Regimens containing 600 mg of zidovudine daily (regimens 2 and 5) were also more likely to result in persistent increases in CD4 counts above pretreatment values than were the two lowest dose regimens (P = 0.003). The decline in CD4 counts was more rapid, and the suppression of the p24 antigenemia was less rapid and less sustained in patients receiving the lowest zidovudine dose alone (regimen 6). The addition of ddC to regimen 6 (regimen 3) resulted in a slower decline in the CD4 counts (P = 0.06). Conclusions: Combination therapy with zidovudine and ddC at the doses tested was well tolerated and did not result in toxicity. A daily oral dose of 150 mg of zidovudine appeared to produce a suboptimal effect on p24 antigenemia and CD4 counts. Combination therapy with ddC and higher doses of zidovudine produced greater and more persistent effects in patients with advanced HIV infection compared with other study regimens and with the results of previous trials of zidovudine monotherapy.
PMO-071 Eleven year regional UK cohort study reveals distinctly different temporal trends between neonatal and paediatric home enteral tube feeding
Authors: C E Paxton, K Wade, R Ardill, H Lee, L Eyles, Y Freer, G Menon, D C Wilson
Journal: Gut (2012)

<h3>Introduction</h3> Home enteral tube feeding (HETF) is increasingly being used to provide nutrition support (NS) for children to promote growth and development. It is unclear if there are differences in the extent of use and temporal usage trends between neonatal and paediatric clinical practice. <h3>Aims</h3> To determine: Absolute numbers of children and neonates discharged on HETF from the regional (SE Scotland) tertiary paediatric and neonatal units, the temporal trends in both paediatric and neonatal HETF over an extended period, and the comparison of these trends. The numbers of neonates transferred on enteral tube feeding (ETF) from the regional neonatal to the regional paediatric unit over the last 2 years of the time period and their outcome in terms of need for HETF. <h3>Methods</h3> A retrospective cohort study (database and clinical note review) to compare numbers of children within the population of 838 573 in Lothian discharged on HETF from the single SE Scottish regional neonatal unit and the single SE Scottish regional paediatric unit, and their inter-relationships. All children and neonates discharged on HETF over the study period 1 July 2000–30 June 2011 were included. The fate of neonatal transfers requiring ETF to the paediatric centre was studied over the period of 1 July 2009–30 June 2011. <h3>Results</h3> 485 Lothian children were discharged on HETF from the regional paediatric hospital (paediatric HETF) compared with 114 from the neonatal unit (neonatal HETF) over the same time period. Over the study period a rise in numbers requiring paediatric HETF was observed (average of 34 per year in 2000–2005 increasing to 55 per year in 2006–2011), however there was a decreasing number requiring neonatal HETF (average of 16 per year in 2000–2005 decreasing to 8 per year in 2006–2011). HETF was primarily used short term in the neonatal group for immaturity alone. During the 2-year period of the study 7/2009–6/2011, 20 neonates were transferred to the regional paediatric unit on ETF; 11 (55%) were subsequently discharged on HETF from the paediatric unit, but these neonatal transfers only accounted for 10% of the total of 103 paediatric HETF discharges. <h3>Conclusion</h3> These novel data firstly demonstrate that the incidence of HETF usage on discharge from a UK paediatric regional centre continues to increase while that from the neonatal unit serving the same region is falling, and secondly that sick neonates transferred on ETF make up only a small number of incident paediatric HETF cases. <h3>Competing interests</h3> None declared.
Adaptive self-directed misbeliefs: More than just a rarefied phenomenon?
Authors: Tadeusz W. Zawidzki
Journal: Behavioral and Brain Sciences (2009)

Abstract I argue that adaptive, self-directed misbeliefs are likely more prevalent and important than McKay &amp; Dennett (M&amp;D) claim. Humans often falsely interpret their own behavior in terms of culturally afforded categories. Despite their falsity, such self-interpretations are often adaptive because of our disposition to behave consistently with them. This makes us easier to interpret by similarly enculturated interactants.
Salivary duct calculi.
Authors: I J Mackenzie
Journal: BMJ (1980)

Our trial has shown (after 200 patients) a decrease in infarct size (approximately one- third) and a reduction in the numbers developing complete infarction in those patients given intravenous beta-blockers within 12 hours of the onset of pain.'The treated group needed less diuretics both in hospital and on discharge, suggesting clinical as well as biochemical and electrophysiological benefit.It is important, as Professor Rose points out, not to dismiss (with small trials) therapy which might reduce morbidity and perhaps mortality by, say, 20% as being clinically insignificant in this common condition.
473. Definitive Identification and Isolation of Embryonic Stem Cell-Derived Target Cells by Adenoviral Conditional Targeting; Efficient Purification of Immature and Mature Cells in the Cardiac Lineage
Authors: Ken-ichiro Kosai, Tomoyuki Takahashi
Journal: Molecular Therapy (2005)

Background and aims: Although pluripotent embryonic stem (ES) cells have great potential for developmental studies and regenerative medicine, the successful use of ES cells is currently hampered by the difficulty of distinctly isolating target cells under viable conditions. One candidate strategy to isolate the majority of cells that lack cell-specific surface antigens would be to express a marker gene under the transcriptional control of a cell-specific promoter. However, the current method is insufficient at handling most cell types especially because the activities of such cell-specific promoters are often too weak to visualize the target cells. Here we show that our novel method of adenoviral conditional targeting achieves efficient and feasible isolation of ES cell-derived target cells; in fact, we purified ES cell-derived immature and mature cells in the cardiac lineage.
Chaos in blood pressure control
Authors: C.D. Wagner, B. Nafz, P.B. Persson
Journal: Cardiovascular Research (1996)

A number of control mechanisms are comprised within blood pressure regulation, ranging from events on the cellular level up to circulating hormones. Despite their vast number, blood pressure fluctuations occur preferably within a certain range (under physiological conditions). A specific class of dynamic systems has been extensively studied over the past several years: nonlinear coupled systems, which often reveal a characteristic form of motion termed "chaos". The system is restricted to a certain range in phase space, but the motion is never periodic. The attractor the system moves on has a non-integer dimension. What all chaotic systems have in common is their sensitive dependence on initial conditions. The question arises as to whether blood pressure regulation can be explained by such models. Many efforts have been made to characterise heart rate variability and EEG dynamics by parameters of chaos theory (e.g., fractal dimensions and Lyapunov exponents). These method were successfully applied to dynamics observed in single organs, but very few studies have dealt with blood pressure dynamics. This mini-review first gives an overview on the history of blood pressure dynamics and the methods suitable to characterise the dynamics by means of tools derived from the field of nonlinear dynamics. Then applications to systemic blood pressure are discussed. After a short survey on heart rate variability, which is indirectly reflected in blood pressure variability, some dynamic aspects of resistance vessels are given. Intriguingly, systemic blood pressure reveals a change in fractal dimensions and Lyapunov exponents, when the major short-term control mechanism — the arterial baroreflex — is disrupted. Indeed it seems that cardiovascular time series can be described by tools from nonlinear dynamics [66]. These methods allow a novel description of some important aspects of biological systems. Both the linear and the nonlinear tools complement each other and can be useful in characterising the stability and complexity of blood pressure control.
Some Test Behaviour Differences between Healthy Men and Male Myocardial Infarction Patients
Authors: H. van Dijl, F.H. Olthuis
Journal: Psychotherapy and Psychosomatics (1970)

A group of healthy men and a group of male myocardial infarction patients were compared for test-behaviour on a list consisting of 69 statements. Each statement has to be rated on a six-point scale. From the material the following conclusions can be drawn: (1) healthy men show a tendency to choose extreme positions as they get older. This correlation is not so evident for myocardial infarction patients; (2) the myocardial infarction patients show a tendency to choose more extreme positions than healthy men, independent of age; (3) on most items the healthy men show a normal frequency distribution over the 6 scale segments or a slant in one direction. The myocardial infarction patients show the reverse. They are inclined to choose extreme positions to both directions of one and the same item, and (4) the findings can be related to the hypothesis that the main feature of the personality of myocardial infarction patients can be described as an exaggeration of otherwise rather normal behaviour patterns characteristic of the western culture today.
Endoscopic submucosal dissection using a novel grasping type scissors forceps
Authors: K. Akahoshi, H. Akahane, A. Murata, H. Akiba, M. Oya
Journal: Endoscopy (2007)

Endoscopic submucosal dissection (ESD) with a knife is a technically demanding procedure that is associated with a high complication rate. The shortcoming of this method is the difficulty in fixing the knife to the target lesion. This difficulty can lead to unexpected incision, resulting in major complications such as perforation and bleeding. To reduce the risk of complications related to ESD, we developed a new grasping type scissors forceps (GSF), which can grasp and incise the targeted tissue using an electrosurgical current. The ESD procedure using the GSF was carried out in an animal model (resected porcine stomachs in vitro). After marking the lesion and injecting a solution into the submucosa, the lesion was separated from the surrounding normal mucosa following complete incision around the lesion using the GSF. A piece of submucosal tissue was grasped and cut with the GSF using an electrosurgical current to achieve submucosal exfoliation. ESD using the GSF was carried out safely and easily without unintentional incision. ESD using GSF appears to be an easy, safe, and technically efficient method for resecting gastrointestinal neoplasms.
What sort of DNAR order is that?
Authors: Charles Foster, Tony Hope
Journal: Journal of the Royal Society of Medicine (2012)

There is considerable confusion over the status of ‘do not attempt resuscitation’ (DNAR) orders. David Tracey's claim against Addenbrookes hospital, in which he claims that the Trust unlawfully inserted a DNAR order into his wife's notes, without consulting with her or him, has brought the issue into the public eye.1 A DNAR order is a statement in the patient's notes to the effect that cardiopulmonary resuscitation (CPR) should not be attempted. This article analyses the legal status of such orders, and outlines some ethical and practical corollaries.

‘DNAR order’ is not a legal term: it refers to two types of direction which are legally very different. The first (which we will call ‘type 1’) is a clinical decision for a patient who lacks capacity: a decision that should be made in the patient's best interests at the time of cardiac arrest. The second (‘type 2’) is an advance decision to refuse resuscitation made by the patient when capacitous and binding on clinicians if valid, and if applicable to the circumstances.
Intracoronary stent implantation with ultrasound guidance for severe coronary artery stenosis after kawasaki disease
Authors: M. Ishii, T. Ueno, M. Ieomura, T. Sugimura, T. Tautsumi, E. Mori, T. Akagi, H. Ikeda, T. Imaizumi, H. Kato
Journal: Journal of the American College of Cardiology (1998)
Grandmothers' role in preventing unnecessary accident and emergency attendances: cohort study
Authors: E. Fergusson, J. Li, B. Taylor
Journal: BMJ (1998)

Social support has an important effect on the way a family uses medical services. 1 2Grandmothers have been shown to influence discipline and care behaviour, 3 4 but possible effects of grandmothers on child health have been little studied.A small retrospective study from Philadelphia in the United States suggested that when grandmothers were involved in a child's care there was a greater use of accident and emergency services. 5Our impression was that the reverse was true in Britain and that grandmothers had a beneficial role in supporting mothers and young children.We decided to investigate whether an involved grandmother affected use of services in our accident and emergency department.
Relation of platelets to catecholamine induced myocardial injury
Authors: C. B. MOSCHOS, B. HAIDER, Y. KHAN, M. M. LYONS, T. J. REGAN
Journal: Cardiovascular Research (1978)

To test the thesis that myocardial injury, induced by catecholamines, is ischaemic in origin due to platelet accumulation in the coronary microvasculature, sustained left intracoronary and systemic infusion of catecholamines in toxic dosage was given to dogs previously infused with autologous 51Cr-labelled platelets. Subsequent determination of tissue radioactivity and electrolytes, as well as electronmicrography, indicated that the induced myocardial injury was not related to microvascular occlusion by platelets.
Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation
Authors: David S. Guttery, Benoit Poulin, Abhinay Ramaprasad, Richard J. Wall, David J.P. Ferguson, Declan Brady, Eva-Maria Patzewitz, Sarah Whipple, Ursula Straschil, Megan H. Wright, Alyaa M.A.H. Mohamed, Anand Radhakrishnan, Stefan T. Arold, Edward W. Tate, Anthony A. Holder, Bill Wickstead, Arnab Pain, Rita Tewari
Journal: Cell Host & Microbe (2014)

Reversible protein phosphorylation regulated by kinases and phosphatases controls many cellular processes. Although essential functions for the malaria parasite kinome have been reported, the roles of most protein phosphatases (PPs) during Plasmodium development are unknown. We report a functional analysis of the Plasmodium berghei protein phosphatome, which exhibits high conservation with the P. falciparum phosphatome and comprises 30 predicted PPs with differential and distinct expression patterns during various stages of the life cycle. Gene disruption analysis of P. berghei PPs reveals that half of the genes are likely essential for asexual blood stage development, whereas six are required for sexual development/sporogony in mosquitoes. Phenotypic screening coupled with transcriptome sequencing unveiled morphological changes and altered gene expression in deletion mutants of two N-myristoylated PPs. These findings provide systematic functional analyses of PPs in Plasmodium, identify how phosphatases regulate parasite development and differentiation, and can inform the identification of drug targets for malaria.