tbuckley/cabot-search huggingface dataset:
(24) Primary amyloidosis
Authors: K.D. Crow
Journal: British Journal of Dermatology (1977)

Journal Article (24) Primary amyloidosis Get access K.D. Crow K.D. Crow Princess Margaret Hospital, Swindon Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 97, Issue s15, 1 December 1977, Pages 58–60, https://doi.org/10.1111/j.1365-2133.1977.tb14332.x Published: 01 December 1977
607 Long-term immunogenicity and efficacy assessment of anti-hepatitis B virus (HBV) vaccination in Italian children
Authors: A. Mariano, A. Mele, T. Stroffolini, L. Romano, M.E. Tosti, F. Marzolini, R. Coppola, M. Cuccia, R. Mangione, F. Negrone, A. Parlato, M. Quarto, P. Ragni, E. Zamparo, C. Zotti, A. Zanetti
Journal: Journal of Hepatology (2004)
Clinical significance of antibodies to ribonucleoprotein.
Authors: M L Cohen, B Dawkins, R L Dawkins, E T Owen
Journal: Annals of the Rheumatic Diseases (1979)

Antibodies to ribonucleoprotein (RNP) were detected by an immunofluorescence technique based on the sensitivity of speckled antinuclear antibodies to ribonuclease. These antibodies were found to identify a group of patients with a consistent set of clinical features, especially arthritis, swollen hands, Raynaud's phenomenon, and myositis. The presence of anti-RNP antibodies in sera from patients with polymyositis, systemic lupus erythematosus, and systemic sclerosis was also associated with these clinical features. Other studies of the clinical significance of these antibodies support the concept that they appear to identify a group of patients with a distinct clinical condition.
Cutaneous Delayed Hypersensitivity Reactions to Soluble Melanoma Antigen in Patients with Ocular Malignant Melanoma
Authors: Devron H. Char, Ariel Hollinshead, David G. Cogan, Elmer J. Ballintine, Michael J. Hogan, Ronald B. Herberman
Journal: New England Journal of Medicine (1974)

We studied the cutaneous delayed hypersensitivity responses to a soluble melanoma antigen in 32 patients with the initial clinical diagnosis of ocular melanoma and in seven control patients. Eighteen out of 19 patients who had pathologically confirmed ocular melanomas were positive to this antigen, as were eight other patients clinically thought to have choroidal melanomas. All seven controls were negative on skin testing with this antigen, as were five patients who were initially thought to have ocular melanomas but who, on extensive work-up, were considered to have other, nonmelanoma, ocular lesions. Thus, patients with ocular malignant melanomas have cell-mediated immunity against an antigen common to systemic malignant melanoma. This delayed hypersensitivity assay may assist in the diagnosis of ocular melanoma, especially in patients with opaque media or those in whom ocular melanoma must be distinguished from metastatic lesions to the choroid. (N Engl J Med 291:274–277, 1974)
HFEA and HTA will not now be axed
Authors: M. Limb
Journal: BMJ (2013)

The UK government has withdrawn plans to abolish two health regulators, to the relief of many leading health bodies.

The Human Tissue Authority (HTA) and the Human Fertilisation and Embryology Authority (HFEA) are to be retained, ministers have decided after a consultation.

An independent review will now follow, to report by April 2013. It will look into how the two bodies could carry out their functions in a …
Case-control study of suicide by discharged psychiatric patients
Authors: J. A Dennehy, L. Appleby, C. S Thomas, E B. Faragher
Journal: BMJ (1996)

Our aim was to evaluate the interobserver agreement in <sup>18</sup>F-sodium fluoride (NaF) PET/CT for the detection of bone metastases in patients with prostate cancer (PCa). <b>Methods:</b><sup>18</sup>F-NaF PET/CT scans were retrieved from all patients who participated in 4 recent prospective trials. Two experienced observers independently evaluated the <sup>18</sup>F-NaF PET/CT scans on a patient level using a 3-category scale (no bone metastases [M0], equivocal for bone metastases, and bone metastases present [M1]) and on a dichotomous scale (M0/M1). In patients with no more than 10 lesions, the location and number of lesions were recorded. On a patient level, the diagnostic performance was calculated using a sensitivity analysis, in which equivocal lesions were handled as M0 as well as M1. <b>Results:</b><sup>18</sup>F-NaF PET/CT scans from 219 patients with PCa were included, of whom 129 patients were scanned for primary staging, 67 for biochemical recurrence, and 23 for metastatic castration-resistant PCa. Agreement between the observers was almost perfect on a patient level (3-category unweighted κ = 0.83 ± 0.05, linear weighted κ = 0.90 ± 0.06, and dichotomous κ = 0.91 ± 0.07). On a lesion level (dichotomous scale), the observers agreed on the number and location of bone metastases in 205 (93.6%) patients. In the remaining 14 patients, the readers disagreed on the number of lesions in 13 patients and the location of bone metastases in 1 patient. A final diagnosis of bone metastases was made for 211 of 219 patients. The sensitivity ranged from 0.86 to 0.92, specificity from 0.83 to 0.97, positive predictive value from 0.70 to 0.93, and negative predictive value from 0.94 to 0.96. <b>Conclusion:</b> The interobserver agreement on <sup>18</sup>F-NaF PET/CT for the detection of bone metastases in patients with PCa was very high among trained observers, both on a patient level and on a lesion level. Moreover, the diagnostic performance of <sup>18</sup>F-NaF PET/CT was satisfactory, rendering <sup>18</sup>F-NaF PET/CT a robust tool in the diagnostic armamentarium.
India's tuberculosis plan sets ambitious targets for next five years
Authors: T. Biswas
Journal: BMJ (2013)

The Indian government has set a target of detecting and treating 8.7 million people with tuberculosis between 2012 and 2017 and 200 000 people with multidrug resistant tuberculosis.

The targets are outlined in the annual report of the Revised National Tuberculosis Control Programme (RNTCP).1 The report has as its theme “universal access for quality diagnosis and treatment for all TB patients in the community.” It emphasises “reaching …
Adopting a Child Today
Authors: Wesley J. Duiker
Journal: JAMA (1965)

The reasoned defense of independent adoptions, developed by an adoptive parent and a legal consultant, is the outstanding feature of<i>Adopting a Child Today</i>. This orientation is particularly provocative in an era when adoption agencies are intent on securing a monopoly in adoption practices. The authors advocate a broadened concept of adoption in view of the situation today, that there are more children available for adoption than adoptive parents. The appeal is that adoption be considered by any who wish a child rather than just the traditional childless couple. The authors reason that the more different kinds of people become involved in adoptions, the easier it will be to live as adoptive parents and children. Since medical science is more apt to solve the problems of infertility than society is likely to prevent illegitimacy, this appeal makes sense. The needs of all potential adopters are well served by the authors'
Tight control of blood glucose and cardiovascular disease
Authors: P. Home
Journal: BMJ (2008)

A strong effect that develops slowly but persists for years

September saw the 10th anniversary of the publication of the landmark United Kingdom Prospective Diabetes Study (UKPDS), which comprised a series of studies that have greatly improved our understanding and practice of controlling blood glucose in people with type 2 diabetes.1 Nevertheless, intensive control in the group treated with sulfonylurea or insulin had an equivocal effect on preventing cardiovascular disease compared with conventional treatment (percentage risk reduction for myocardial infarction 16%, 95% confidence interval 0% to 19%), with the P value of 0.052 on the boundary of conventional statistical significance.2 A study of intensive control with metformin in overweight people seemed to give clearer results (39%, 11% to 59%),3 but the study was underpowered, and a subgroup analysis in people taking metformin plus sulfonylurea raised the potential of harm.

However, October saw the publication of the results of the UKPDS 10 year follow-up study, which found that patients in the sulfonylurea or insulin group had a significant 15% reduction in myocardial infarction even though they achieved the same glucose control as patients in the less tightly controlled group over the five year extension.4 The results reflect those of the Diabetes Control and Complications Trial in type 1 diabetes. This also found no effect of glucose control on cardiovascular outcomes (with …
Survival and Risk Factors for Death After Cardiac Transplantation in Infants
Authors: Charles Canter, David Naftel, Randall Caldwell, Richard Chinnock, Elfriede Pahl, Elizabeth Frazier, James Kirklin, Mark Boucek, Robert Morrow
Journal: Circulation (1997)

Despite the increasing application of cardiac transplantation in infants, reported survival rates vary, and risk factors for death are poorly understood.To examine early survival and risk factors for death in infants (< 1 year of age) undergoing cardiac transplantation, 141 infants (36 < 1 months of age) underwent primary cardiac transplantation between January 1, 1993, and January 1, 1995, at 23 centers in the Pediatric Heart Transplant Study (PHTS). Diagnoses were hypoplastic left heart syndrome (66%), other congenital heart disease (17%), cardiomyopathy (14%), and other (3%). Actuarial survival after cardiac transplantation was 84% at 1 month, 70% at 1 year, and 69% at 2 years, with the greatest hazard for death within the first 3 months. The principal cause of death was early graft failure in 20 patients (52% of deaths), infection in 10 (26% of deaths), and rejection in 4 (10%). On the basis of multivariate analysis, risk factors for early mortality were history of previous sternotomy (P = .0003), nonidentical blood type donor (P = .01), recipient non-blood group A (P = .02), and donor cause of death other than closed head trauma (P = .04). Diagnosis at listing, waiting time (mean, 1.3 months), graft ischemic time (mean, 228 minutes; range, 68 to 479 minutes), and recipient ventilatory or inotropic support at listing were not predictive for mortality after transplant.The higher mortality rate observed with infant heart transplantation is due to a higher mortality within the first month after transplantation as a result of early graft failure. Strategies to improve donor heart function at implantation would have the greatest impact on survival after infant cardiac transplantation.
Racism rife in the medical profession, BMA report says
Authors: D. Singh
Journal: BMJ (2003)

Racism blocks the career progression of doctors from ethnic minorities and from overseas, a BMA report has said.

The BMA report is part of a cohort study tracking the careers of 476 medical graduates who qualified in 1995 and offers a snapshot representation of doctors' careers. Doctors participating in the survey were asked their views on whether their ethnicity was a factor in their career progression. Four focus groups involving 33 doctors were used to explore the issue in greater …
Abstract 5182: MSP58 regulates telomerase activity and cell proliferation via interaction with TEIF.
Authors: Che-Chia Hsu
Journal: Cancer Research (2013)

Abstract Telomerase expression is essential for cell proliferation and survival, which also plays a role in development, senescence and cancer. In our previous studies, we demonstrated that ectopic expression MSP58 regulates cell proliferation in context-dependent manner and induces premature senescence in HT1080 cells and normal human diploid fibroblasts through p53/p21 senescence pathway. In addition, we also demonstrated that MSP58 overexpression significantly suppressed telomerase activity in HT1080 cells. Currently, we identified a novel MSP58 interacting protein, TEIF (Telomerase transcription element-interacting factor) by yeast-two hybrid screening. TEIF has been reported to up-regulate the hTERT gene expression and telomerase activity. Interestingly, we found that MSP58 represses the TEIF-mediated activation of telomerase. Furthermore, overexpression of MSP58 represses TEIF promoted anchorage-independent growth in HT1080 cells. In contrast, knockdown MSP58 expression increases TEIF promoted anchorage -independent growth in HT1080 cells. These results suggest that MSP58 regulates telomerase activity via interaction with TEIF and contributes to control cell proliferation. Citation Format: Che-Chia Hsu. MSP58 regulates telomerase activity and cell proliferation via interaction with TEIF. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5182. doi:10.1158/1538-7445.AM2013-5182
Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors
Authors: P Patel, M A Mendall, D Carrington, D P Strachan, E Leatham, N Molineaux, J Levy, C Blakeston, C A Seymour, A J Camm, T C Northfield
Journal: BMJ (1995)

<h3>Abstract</h3> Objective: To investigate the relation between seropositivity to chronic infections with Helicobacter pylori and Chlamydia pneumoniae and both coronary heart disease and cardiovascular risk factors. Objective:To investigate the relation between seropositivity to chronic infections with Helicobacter pylori and Chlamydia pneumoniae and both coronary heart disease and cardiovascular risk factors. Setting: General practices in Merton, Sutton, and Wandsworth, south London. Subjects: 388 white south London men aged 50-69. Main outcome measures: Evidence of coronary risk factors and infection with H pylori or C pneumoniae. Results: 47 men (12.1%) had electrocardiographic evidence of ischaemia or infarction. 36 (76.6%) and 18 (38.3%) were seropositive for H pylori and C pneumoniae, respectively, compared with 155 (45.5%) and 62 (18.2%) men with normal electrocardiograms. Odds ratios for abnormal electrocardiograms were 3.82 (95% confidence interval 1.60 to 9.10) and 3.06 (12.33 to 7.01) in men seropositive for H pylori and C pneumoniae, respectively, after adjustment for a range of socioeconomic indicators and risk factors for coronary heart disease. Cardiovascular risk factors that were independently associated with seropositivity to H pylori included fibrinogen concentration and total leucocyte count. Seropositivity to C pneumoniae was independently associated with raised fibrinogen and malondialdehyde concentrations. Conclusions: Both H pylori and C pneumoniae infections are associated with coronary heart disease. These relations are not explained by a wide range of confounding factors. Possible mechanisms include an increase in risk factor levels due to a low grade chronic inflammatory response.
Sepsis and the Heart
Authors: M.W. Merx, C. Weber
Journal: Circulation (2007)

Sepsis is generally viewed as a disease aggravated by an inappropriate immune response encountered in the afflicted individual. As an important organ system frequently compromised by sepsis and always affected by septic shock, the cardiovascular system and its dysfunction during sepsis have been studied in clinical and basic research for more than 5 decades. Although a number of mediators and pathways have been shown to be associated with myocardial depression in sepsis, the precise cause remains unclear to date. There is currently no evidence supporting global ischemia as an underlying cause of myocardial dysfunction in sepsis; however, in septic patients with coexistent and possibly undiagnosed coronary artery disease, regional myocardial ischemia or infarction secondary to coronary artery disease may certainly occur. A circulating myocardial depressant factor in septic shock has long been proposed, and potential candidates for a myocardial depressant factor include cytokines, prostanoids, and nitric oxide, among others. Endothelial activation and induction of the coagulatory system also contribute to the pathophysiology in sepsis. Prompt and adequate antibiotic therapy accompanied by surgical removal of the infectious focus, if indicated and feasible, is the mainstay and also the only strictly causal line of therapy. In the presence of severe sepsis and septic shock, supportive treatment in addition to causal therapy is mandatory. The purpose of this review is to delineate some characteristics of septic myocardial dysfunction, to assess the most commonly cited and reported underlying mechanisms of cardiac dysfunction in sepsis, and to briefly outline current therapeutic strategies and possible future approaches.
Focus of Recurrent Septicemia Due to Klebsiella ozena Detected by Indium Leukocyte Scintigraphy
Authors: J F KENNEDY, M K O??CONNOR, H HUMPHREYS, C COONEY
Journal: Clinical Nuclear Medicine (1987)

A case of recurrent septicemia by an unusual organism, Klebsiella ozena, in which the focus of infection was detected by Indium leucocyte scintigraphy. Klebsiella ozena is an uncommon organism usually associated with granulomatous and nectrotizing disease of the upper airways. This poses obvious difficulties in locating the source of infection when this organism is causing septicemia as in this case. Physical and radiographic examinations failed to reveal the primary focus of infection. This case underlines the value of Indium leucocyte scintigraphy in locating the source of infection in patients with pyrexia of unknown origin.
Human Antiserum for Prevention of the Local Shwartzman Reaction and Death from Bacterial Lipopolysaccharides
Authors: Elizabeth J. Ziegler, Herndon Douglas, Abraham I. Braude
Journal: Journal of Clinical Investigation (1973)

Bacterial lipopolysaccharides from dead bacteria have been blamed for the continuing high mortality from gram-negative infections despite antibiotic treatment. Because animal antiserum against these lipopolysaccharides has been shown to protect against several of the effects of endotoxin, we undertook the development of antiserum in human subjects. 21 men were immunized with a single injection of Salmonclla typhimurium or Escherichia coli 0:111 heat-killed cells and immune serum was collected at 2 wk. Preimmune serum was obtained as a control in all animal experiments. 1 ml antiserum given intravenously protected mice against a lethal intravenous dose of homologous endotoxin (P < 0.005 for both antisera). E. coli antiserum reduced the incidence of positive local Shwartzman reactions with E. coli endotoxin from 100 to 38%; S. typhimurium antiserum reduced the incidence from 92 to 35%. (P < 0.0005 for both antisera). There was no protection against heterologous endotoxin in either animal model. These experiments demonstrate for the first time that human antiserum confers exceedingly potent passive immunity to the effects of endotoxin.
A computer program using BALF-analysis results as a diagnostic tool in interstitial lung diseases.
Authors: M Drent, M A van Nierop, F A Gerritsen, E F Wouters, P G Mulder
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Recently, we showed that it is possible to distinguish between three common interstitial lung diseases (ILD) with similarities in clinical presentation by using a number of selected variables derived from bronchoalveolar lavage fluid (BALF) analysis. The aim of this study was to develop a more general discriminant model, based on polychotomous logistic regression analysis. The 277 patients involved in the study belonged to diagnostic groups with sarcoidosis (n = 193), extrinsic allergic alveolitis (EAA; n = 39), and idiopathic pulmonary fibrosis (IPF; n = 45). The diagnosis had been established independently of the BALF-analysis results. The variables used to discriminate among these patient groups were the yield of recovered BALF, total cell count, and percentages of alveolar macrophages, lymphocytes, neutrophils, and eosinophils. In order to test the predictive power of the logistic model, we used 128 patients having sarcoidosis (n = 91), EAA (n = 5), or IPF (n = 32) from another hospital. In this test set the agreement of predicted with actual diagnostic-group membership was the same as in the learning set in which the logistic model was fitted: 94.5% of the cases were correctly classified. A validated computer program based on the polychotomous logistic regression model can be used to predict the diagnosis for an arbitrary patient with information provided by BALF analysis, and is thought to be of diagnostic value in patients suspected of having ILD.
Introductory Lecture on Teaching &amp; Learning Medicine: Delivered in the Author's Winter Course of Lectures on the Principles and Practice of Medicine
Authors: B. Bramwell
Journal: BMJ (1897)

~~~~~~~~~~~~~~~~~~~~~Ĩ n connection with the subject of nasal deformity, I take this opportunity of describing and illustrating a plastic operation which I performed a few years ago in order t.) cover over an ugly opening resulting from the loss of the entire nose and surrounding textures of the cheeks (Fig. i).This patient.had been subjected to several operations for recurring rodent ulcer, which had neces'sitated the removal of the whole nose ' ~~~~~' Fig. 4 asnd a' large portion of the cheeks.The tissues all round the deficelncy, exposing the nasal cavities were cicatricial, and coutld not be used to cover over the gap.As thepatient was .veryanxious to have .the,openiing closed, I perform-Id -with1 success the following procedure.One flap (Fig. I A) was cut from the forehead, and left attached at its upper end.A second flap, B, was cut from the tissues of the upper lip, its base towards the lip was not carried down through the margin, but terminated a little above the position of the coronary artery, and was left attacbed there, so that the nourishment of the dap was not interfered with.The edge of the opening were then pared, and the two flaps having been separated from their attachments except at their bases, were brought together over the opening and secured by stitches.When the flaps were stitched together the centre of the upper lip was drawn up so as to expose the front teeth of the upper jaw, but when the the circulation in the flaps had been thoroughly established a second operation for relieving this was performed by cutting through the lip on each side of the drawn-up portion, and then bringing together the divided surfaces of the lip, as in a case of harelip.In Fig. 2 the result of this operation, which was entirely successful in closing the opening, is shown.One trouble re- mained, and it was that the lower flap, having been taken from the upper lip, was covered with hair, but the patient preferred this to the unsightly gap which had previously existed.