tbuckley/cabot-search huggingface dataset:
When Was the First Gastrectomy?
Authors: S. D. Sarkar
Journal: BMJ (1964)

no knowledge as to whether it is a widely recognized occurrence.Last year I was treating an elderly lady who suffered from congestive heart failure and severe osteoarthritis of her knees.Oral diuretics were insufficient to control the ex- tensive oedema of her legs and it seemed desirable to reinforce this with weekly injec- tion of " neptal " (o-(2-hydroxy-3-hydroxymercuripropylcarbomyl) phenoxyacetic acid and theophylline).This produced a satisfac- tory diminution in the oedema, but it became very evident that on each occasion it was accompanied by exacerbation of the pain in her knees, which improved as the oedema re- formed in the course of the next few days.Your article suggests that the lubrication of joints depends on the viscosity of the synovial fluid rather than on the quantity, but the inference I drew from my patient was that the bone surfaces were being kept separated by an increased volume of intra-articular fluid, as part of the general oedema of the leg, and that the diuretic produced a relative intra-articular dehydration and consequent friction.At all events the patient was grate- ful when I treated her oedema less diligently.-I am, etc.,
Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4
Authors: Ruby F. Fernandez-Boyanapalli, S. Courtney Frasch, Kathleen McPhillips, R. William Vandivier, Brian L. Harry, David W. H. Riches, Peter M. Henson, Donna L. Bratton
Journal: Blood (2008)
Hypersensitivity Pneumonitis and Toluene Diisocyanate
Authors: Leslie Grammer
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 October 1989Hypersensitivity Pneumonitis and Toluene DiisocyanateLeslie Grammer, MDLeslie Grammer, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-8-690_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:I am writing in response to the article by Yoshizawa and colleagues (1) on hypersensitivity pneumonitis and toluene diisocyanate. Two areas deserve comment. First, the authors state that the worker developed hypersensitivity pneumonitis 1 week after he began working with paint materials containing toluene diisocyanate. In the absence of previous exposure, hypersensitivity pneumonitis does not develop after 1 week of exposure. Second, it does not appear that the worker's exposure was "continuous" as the title of the article suggests. His exposure was probably almost nil if he was wearing the "preventive oxygen-powered mask." His subsequent absence of...Reference References1. YoshizawaOhtsukaNoguchiUchidaSukoHasegawa YMKYMS. Hypersensitivity pneumonitis induced by toluene diisocyanate: sequelae of continuous exposure. Ann Intern Med. 1989;110:31-4. LinkGoogle Scholar1. YoshizawaOhtsukaNoguchiUchidaSukoHasegawa YMKYMS. Hypersensitivity pneumonitis induced by toluene diisocyanate: sequelae of continuous exposure. Ann Intern Med. 1989;110:31-4. LinkGoogle Scholar2. FujimuraKinoNagai NTS. Hypersensitivity pneumonitis in a polyurethane paint sprayer. Jpn J Thorac Dis. 1984;22:506-13. Google Scholar3. BascomKennedyLevitzZeiss RTDC. Specific Bronchoalveolar Lavage IgG Antibody in Hypersensitivity Pneumonitis from Diphenylmethane Diisocyanate. Am Rev Respir Dis. 1985;131:463-5. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByOccupational asthma and extrinsic alveolitis due to isocyanates: current status and perspectives. 15 October 1989Volume 111, Issue 8Page: 690-691KeywordsHypersensitivityPneumonitis Issue Published: 15 October 1989 PDF DownloadLoading ...
Specific tumor targeting and activation of Vγ9Vδ2 T cells by bi-specific nanobodies
Authors: Anita Stam, Renée de Bruin, Rob Roovers, Paul van Bergen en Henegouwen, Henk Verheul, Tanja D de Gruijl, Hans van der Vliet
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Gamma delta T cells expressing the Vγ9Vδ2 T cell receptor (TCR) are the most predominant γδ-T cell subset in peripheral blood accounting for approximately 1-5 % of all T cells. Vγ9Vδ2 T cells recognize phosphoantigens (pAg) such as isopentenyl pyrophosphate (IPP), a
Abstract 1138: Rapid validation of a novel kinase target using a large scale genomic database and matched patient derived tumor models.
Authors: Thomas Broudy, Sandeep Sanga, Jill Ricono, Mohit Trikha, Cyrus Mirsaidi, Kesavan Nair Praveen
Journal: Cancer Research (2013)

Abstract Target discovery and validation in oncology has largely relied on molecular and functional studies performed in cell lines. Recent advances in genomics have now afforded large databases based on well-characterized tumor tissue, which has enabled direct investigation of patient tumors for novel targets. Following these discoveries, it is routine to perform functional studies in cell line-based systems; however, it is often difficult to find relevant cell line model and if identified, they can be confounded with artifacts created from decades of culture. The result can be a target validation process which takes considerable time and does not readily translate to clinical relevance. We report here the creation and use of a target validation platform based on a large-scale genomic database matched to patient-derived tumor models. The platform relies on Molecular Response's proprietary bank of more than 144,000 patient derived tumors, of which nearly 400 tumors have been genomically characterized and databased for target discovery studies. The database is growing, but currently features the following cancer indications: colon carcinoma, NSCLC, melanoma, ovarian carcinoma, prostate and non-hodgkins lymphoma. Upon discovery of a novel target, tumors of interest are immediately implanted into mice to perform functional studies in direct patient derived models–either in vivo or using mouse-passaged cells for broader ex vivo studies. Through use of this platform, we have identified a novel kinase target for potential therapeutic development. We investigated prevalence of target overexpression across 7 cancer indications, and identified melanoma as a clinical indication of high interest. We examined growth characteristics from patient tumors featuring high kinase gene expression vs. low expression to help characterize the role of this target in oncology disease progression. Finally, we performed functional knockdown studies in patient derived models to further validate this novel kinase as a druggable target of pharmaceutical interest. Studies are ongoing to develop small molecule and antibody-based therapeutics that will serve as drug candidates for further development. Citation Format: Thomas Broudy, Sandeep Sanga, Jill Ricono, Mohit Trikha, Cyrus Mirsaidi, Kesavan Nair Praveen. Rapid validation of a novel kinase target using a large scale genomic database and matched patient derived tumor models. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1138. doi:10.1158/1538-7445.AM2013-1138
Modern Health Care for All Americans
Authors: Barack Obama
Journal: New England Journal of Medicine (2008)

Health Care Reform and the Presidential CandidatesThe editors asked Senator John McCain, the Republican presidential nominee, and Senator Barack Obama, the Democratic presidential nominee, to describe their plans for reforming the U.S. health care system. Their statements follow. In order to explore their positions in greater depth, the Journal and the Harvard School of Public Health cosponsored a Perspective Roundtable on September 12, 2008, entitled “Health Care in the Next Administration” and featuring senior health policy advisors David Cutler for Senator Obama and Gail Wilensky for Senator McCain. A video of the symposium can be seen at www.nejm.org.Doctors . . .
Tc-99m-MIBI-Negative Parathyroid Adenoma in Primary Hyperparathyroidism Detected by C-11-Methionine PET/CT After Previous Thyroid Surgery
Authors: Matthias C. Schmidt, Deniz Kahraman, Bernd Neumaier, Monika Ortmann, Dirk Stippel
Journal: Clinical Nuclear Medicine (2011)

A 64-year-old woman with previous thyroid surgery developed symptomatic primary hyperparathyroidism, requiring hydration and furosemide. Cervical ultrasonography and an MRI of the neck were inconclusive. Early Tc-99m-methoxyisobutylisonitrile images 15 minutes post injection demonstrated focal uptake in the left lower thyroid lobe consistent with a small thyroid adenoma. Neither subtraction or late planar nor Tc-99m-methoxyisobutylisonitrile-SPECT images identified a focal area of increased uptake. PET/CT with 460 MBq C-11-methionine demonstrated a focal area of increased uptake in the right thyroid bed. Subsequent surgery confirmed a parathyroid adenoma of 1.4 cm in diameter. Histopathologic analysis showed a parathyroid adenoma of chief-cell type.
808-4 The Presence and Duration of an Excitable Gap During Ventricular Fibrillation in a Canine Model of Myocardial Infarction
Authors: George Horvath, Nikhil Patel, Roger S. Damle, Sandeep Jam, Nikki S. Robinson, Jeffrey J. Goldberger, Alan H. Kadish
Journal: Journal of the American College of Cardiology (1995)
Effects of Qigong on Glucose Control in Type 2 Diabetes
Authors: Guan-Cheng Sun, Jennifer C. Lovejoy, Sara Gillham, Amy Putiri, Masa Sasagawa, Ryan Bradley
Journal: Diabetes Care (2009)

Qigong is a traditional Chinese energy medicine practice combining breathing, movement, and meditation. Although previous studies suggest that Qigong may be a beneficial adjunct treatment for individuals with type 2 diabetes (1–3), few randomized controlled trials of Qigong in patients with type 2 diabetes have been performed. The purpose of the present study was to investigate the effects of Qigong relative to physical exercise or standard care on glucose control in adults with type 2 diabetes.

Two hundred fifty-one potential subjects were phone screened, 46 individuals were further evaluated at Bastyr University, and 32 eligible participants enrolled in the study. Age- and sex-matched participants were randomly assigned to one of three groups: group 1 ( n = 11) received the Qigong intervention, group 2 ( n = 10) …
THE CASE OF TINEA TONSURANS (MICROSPORON) IN AN ADULT
Authors: W. JENKINS OLIVER
Journal: British Journal of Dermatology (1917)

Journal Article THE CASE OF TINEA TONSURANS (MICROSPORON) IN AN ADULT Get access W. JENKINS OLIVER, B.M. W. JENKINS OLIVER, B.M. Skin Department, London Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 29, Issue 1, 1 January 1917, Pages 34–35, https://doi.org/10.1111/j.1365-2133.1917.tb09648.x Published: 01 January 1917
Data, data everywhere
Authors: Des Spence
Journal: BMJ (2013)

A news story ran just after I was accepted to university. Scientists were testing a computer that made clinical diagnoses, and it was predicted that doctors would be replaced by robots within the decade. It never happened, though many now joke that doctors have indeed been replaced by mindless robots and just follow flowcharts of care. Medicine is complex, and experience teaches us that blind adherence to any clinical guideline or algorithm always ends in tears.

Today’s technological leap is “big …
Primary cutaneous medium and large cell lymphomas other than mycosis fungoides. An immunohistological and follow-up study on 54 cases
Authors: P. JOLY, E. VASSEUR, E. ESTEVE, M. LEIBOWITCH, H. TILLY, L. VAILLANT, J. WECHSLER, E. THOMINE, A. MURET, F. DREYFUS, Ph. COLOMBAT, Ph. LAURET, M. BAGOT
Journal: British Journal of Dermatology (2006)

Summary Primary cutaneous medium and large cell lymphomas (MLCL) other than mycosis fungoides (MF) are rare, and their prognosis and treatment are controversial. The clinical, immunohistological and follow-up data of 54 well-documented cases of primary cutaneous MLCL other than MF, seen in our institutions over a 14-year period, were retrospectively reviewed, in order to determine the prognostic factors related to these lymphomas, and to analyse the results obtained with different treatment regimens. Forty-six patients presented with a solitary tumour or with localized lesions. and eight had disseminated cutaneous lesions. According to the updated Kiel classification, 45 cases (83%) corresponded to B-cell lymphomas: centroblastic lymphomas, 32 cases; centroblastic-centrocytic lymphomas, 11 cases; immunoblastic lymphomas, two cases. Nine cases (17%) were classified as T-cell lymphomas: pleomorphic medium and large cell lymphomas, eight cases; anaplastic large cell lymphoma. one case. Four of eight patients with disseminated skin lesions had a T-cell lymphoma. whereas 41 of 46 patients with a solitary tumour had a B-cell lymphoma. Patients with disseminated skin lesions and elevated serum lactate dehydrogenase (LDH) levels had a poor prognosis. Comparison of patients' overall survival, depending on immunohistological subtype, showed that the median survival of patients with pleomorphic T-cell lymphoma was 2·5 years, whereas it was not reached at 12 years for patients with centroblastic centrocytic and centroblastic lymphoma. The eight patients with disseminated skin lesions were treated with polychemotherapy. Most patients with a solitary tumour or with localized lesions of low tumour bulk were treated by surgical excision or radiotherapy alone, and nine other patients with localized lesions of high tumour bulk were treated with initial polychemotherapy. Clinical presentation (i.e. solitary or disseminated lesions), serum LDH levels, and the immunohistological subtype, are important prognostic factors in cutaneous MLCL. Patients with disseminated skin lesions have a poor prognosis, and should be treated with intensive polychemotherapy regimens, whereas those with a solitary tumour, or with localized lesions of low tumour bulk, are adequately treated by radiotherapy.
The Challenges and Possibilities of Reducing Deaths from Cryptococcal Meningitis in Sub-Saharan Africa
Authors: Andrew W. K. Farlow
Journal: PLoS Medicine (2012)

With increased access to life-saving drugs, HIV is becoming less of a death sentence in developing countries.But death may still occur as a result of opportunistic infections, one of the most common being cryptococcal meningitis (CM), a fungal infection of the brain and spinal cord that primarily affects people with weakened immune systems.Of the estimated 960,000 people each year infected with CM worldwide-about threequarters in sub-Saharan Africa-approximately 625,000 (65%) die within 3 months of infection [1].In this issue of PLOS Medicine, Radha Rajasingham and colleagues argue that, for relatively little cost and with drugs that already exist, about 150,000 more CM deaths could be prevented every year in sub-Saharan Africa.Using available trial data and a variety of cost evidence, the authors calculate the cost-effectiveness of six CM induction treatment regimes under resource-limited conditions.Two results stand out.First, the least cost-effective regimen is high-dose fluconazole monotherapy, which has been associated with a nearly 2-fold higher 10week mortality rate and about 30% greater absolute mortality than the shortcourse (5-7 days) amphotericin-based regimen.Second, long-course (14 days) amphotericin-based regimens, as recommended by the World Health Organization (WHO), are not only more costly but appear to be no more effective than shortcourse amphotericin-based regimens.If the second finding is confirmed in further trials, the WHO will need to adjust its advice.Doing Nothing Is Costly, Change Is Difficult, and Inertia Is Harmful
FDA: Increased HBV Reactivation Risk With Ofatumumab or Rituximab
Authors: Mike Mitka
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On the possibility of automated scoring of pollen mutants.
Authors: D Pinkel
Journal: Environmental Health Perspectives (1981)

Both flow cytometry and automated image analysis techniques may be useful in relieving the drudgery, increasing the speed, and adding quantitation to the scoring of pollen mutants, but practical problems related to the detection of very rare events have to be overcome. The features of flow and image cytometry instrumentation that may be useful for pollen measurements are discussed and a qualitative framework is presented from which to view the rare event problem.
UK bans powerful laser pointers
Authors: K. Abbasi
Journal: BMJ (1997)

The British government has banned the most powerful laser pointers because they could cause retinal damage if shone directly into the eye. The pens are used as presentation aids, but they have also been misused to distract goalkeepers, policemen, and drivers at night.

Dr Ajoy Kar, reader in physics at Herriot-Watt University in Edinburgh, used sophisticated calibrated laser power meters to show that …
Doctors in masks
Authors: T Smith
Journal: BMJ (1994)

Doctors in the United States who treat patients with pulmonary tuberculosis are being recommended to use powered air respirators - described in JAMA (1993;270:1903) as more at home in coal mines than hospitals and already nicknamed “Darth Vader” masks by those expected to use them. The masks are only one part of a comprehensive set of protective measures drawn up by the Occupational Safety and Health Administration, modified by revisions recommended by the Centers for Disease Control and Prevention. These two government agencies have prepared guidelines that cover isolation rooms, ultraviolet germicidal radiation, and the screening of health care workers, but the …
Immune system dysregulation in chronic lung disease
Authors: B.J. Marsland, M. Königshoff, S. Saglani, O. Eickelberg
Journal: European Respiratory Journal (2011)

Chronic lung diseases (CLDs), including chronic obstructive pulmonary disease (COPD), asthma, lung cancer, interstitial lung disease and pulmonary hypertension, present a significant and rising global health problem. CLDs develop at the interface between genetic susceptibilities and environmental aspects, and are currently the second leading cause of death worldwide. Thus far, therapies of only limited effect exist for CLDs; the search for novel and effective therapeutic strategies has been at the centre of recent major research efforts. As part of the pathogenesis of many CLDs, ill-defined lung injuries and failed repair mechanisms ultimately lead to perturbed lung architecture that is incompatible with normal respiratory function. In particular, the immunological mechanisms that initiate and maintain CLD remain to be fully unravelled.

The mission of the European Respiratory Society (ERS) is to alleviate suffering from respiratory disease and promote lung health through research, knowledge sharing, and medical and public education. In support of this mission, the ERS holds an annual Lung Science Conference (LSC), which brings together leading basic scientists with physician scientists and clinicians on distinct topics that are of relevance to respiratory medicine.

In April 2011, world-leading scientists and clinicians met at the ninth LSC in Estoril, Portugal, to share their latest discoveries and to work towards identifying the cellular and molecular pathways that underlie the development of CLDs. The meeting highlighted major novel findings in immune system (dys)function in the major CLDs, as outlined in detail below. Some of the presentations discussed can be found in the E-Resources on the ERS website (at http://www.ers-education.org/pages/default.aspx?id=2556).

The incidence of asthma has been steadily increasing in recent decades and intensive research has particularly focused upon the role of T-helper cell (Th) type 2 responses and therapies designed to neutralise the activity of Th2-associated cytokines, such as interleukin (IL)-4, IL-5 and IL-13. Disappointing …
Procedures in practice. Hormone implantation.
Authors: M H Thom, J W Studd
Journal: BMJ (1980)

HORMONE IMPLANTATIONThe implantation of pellets of oestradiol into the fat of the abdominal wall or buttock has been used for 30 years, mainly to treat young-patients who insertion site have undergone hysterectomy and bilateral oophorectomy.More recently .,,ld its use has been extended to patients with an intact uterus, and potential complications of endometrial hyperplasia and heavy vaginal bleeding are . .\ avoided by adding a seven-to 13-day course of a progestogen each month. IndicationsTreatment of the climacteric-Subcutaneous hormone implants are principally used to treat the symptoms of the climacteric.When classic symptoms such as hot flushes, sweats, insomnia, vaginal dryness, and dyspareunia predominate a pellet of oestradiol 50 mg may be sufficient.Adding testosterone 100 mg to the oestradiol pellet, however, is effective in treating the related climacteric symptoms of loss of libido, lethargy, and depression.The sense of wellbeing induced by the anabolic effect of ...........
Retinoblastoma in grandchildren of workers at Sellafield nuclear plant.
Authors: J A Morris, J M Edwards, J Buckler
Journal: BMJ (1990)

disease may have greatly increased energy requirements because of their abnormal neuromuscular state.The findings presented here show that energy expenditure can vary at different stages of the day.Nevertheless, it seems that increased energy requirements may be an important contributor to the clinical syndrome of thinness in Parkinson's disease and we suggest that this should be considered in the nutritional management of such patients.We are grateful for a research fellowship from the Parkinson's Disease Society.
The Bile Duct System and its Anatomical Variations
Authors: K. Charels, G. Klöppel
Journal: Endoscopy (1989)

The embryology and anatomy as well as the variations and abnormalities of the biliary system are briefly reviewed. Emphasis is placed upon the intimate anatomical relationship between extrahepatic bile duct, gallbladder, head of the pancreas and its vascular supply. The variations and abnormalities of the biliary system relevant to the endoscopist and surgeon are stressed.