tbuckley/cabot-search huggingface dataset:
Drug-Induced Myositis Ossificans Circumscripta
Authors: Bok S. Chung
Journal: JAMA (1973)

<h3>To the Editor. —</h3> Deutsch<sup>1</sup>recently coined the term "drug abuser's elbow" and described a single case. A further case is presented in which a satisfactory result was obtained by surgical means. The biochemical mechanisms of myositis ossificans are poorly understood. Ackerman<sup>2</sup>believed that extraosseous metaplasia of injured muscle occurred, whereas Shipley<sup>3</sup>suggested that ossification of periosteal hematoma gives rise to the condition. <h3>Report of a Case.—</h3> In December 1972 a 29-year-old black drug addict tried repeatedly and unsuccessfully to inject heroin into his right antecubital vein. He stated that swelling, tenderness, and redness developed in that area, and within four weeks he suffered a "frozen" elbow. He had been treated initially with warm compresses and antibiotics for one week and x-ray studies at that time were reported to have given normal findings. On admission to the Detroit General Hospital in March 1973, there were no signs
284. CD137L Gene Transfer Generates Effective and Long-Lasting Immunity in a Murine Plasmocytoma Model
Authors: Young Kim, John W. Strehl, Marcus Gorschluter, Carsten Ziske, Christine Mayr, Ingo G.H. Schmidt-Wolf
Journal: Molecular Therapy (2005)

Background: CD137L, a member of the tumour necrosis factor receptor (TNFR) family, is constitutively expressed on activated antigen-presenting cells. In a wide range of solid tumours, over-expression of CD137L has been shown to produce tumour immunity. This was at least partly due to the stimulation of CD8+ CTL. Costimulation by other known interactions was not unconditionally necessary. Anti-tumour effects were even increased when immunotherapy with Interleukin-12 was additionally employed, either systemically or locally. Yet, there is rare data on the effect of CD137L immunotherapy in hematological malignancies. Here, we present data obtained in a murine plasmocytoma model to evaluate the effect of CD137L and IL-12, either as mono- or combination therapy.
Risk factor scoring for coronary heart disease
Authors: H.-W. Hense
Journal: BMJ (2003)

Prediction algorithms need regular updating 

Global risk assessment has become an accepted component of clinical guidelines and recommendations in cardiovascular medicine. The aim is to provide a valid estimate of the probability of a defined cardiovascular event over a period of five or ten years in individuals free of clinical manifestations of cardiovascular disease at the time of examination. The information available for global risk assessments commonly consists of individual risk factor measurements and a basic assessment of concurrent clinical conditions. The aim of the resulting absolute level of predicted risk is to determine the intensity of clinical intervention. What do we know about the validity of the population data from which the individual risk factor measurements are derived?

The Framingham Heart Study and the Framingham Offspring Study were the first epidemiological studies that prospectively collected population based data on the association between risk factors and the occurrence of fatal and non-fatal coronary and other cardiovascular events in a systematic and sustained …
Liver Flukes in Common Bile-duct
Authors: J. L. Sagar
Journal: BMJ (1962)

animals (given 2 mg. on the day preceding and on the day of the encephalitogenic injection) were reported as manifesting an early onset and unusual severity of neurological disturbance, while the disease was also thought to be histologically intensified.In a much larger series of prednisolone-treated animals (40) we could not substantiate these findings, though it must be conceded that we administered 0.1 ml.(= 2 mg.) daily on the lines employed in clinical trials. SUMMARYEvidence is presented that corticotrophin is more effective than prednisolone in mitigating the experi- mental encephalomyelitis induced in guinea-pigs by the inoculation of brain emulsion with Freund adjuvant.We thank the board of governors of the Royal Victoria Infirmary, the Multiple Sclerosis Society, and the North- East Multiple Sclerosis Trust for their generous financial support.We are grateful to Mr. D.
Right Ventricular Diastolic Function in Children With Pulmonary Regurgitation After Repair of Tetralogy of Fallot: Volumetric Evaluation by Magnetic Resonance Velocity Mapping
Authors: Willem A. Helbing, R. Andre Niezen, Saskia Le Cessie, Rob J. Van Der Geest, Jaap Ottenkamp, Albert De Roos
Journal: Journal of the American College of Cardiology (1996)
Spinal Disorders: Diagnosis and Treatment
Authors: Oscar Sugar
Journal: JAMA (1978)

An integrated approach by neurosurgeon and orthopedist was planned in this book, designed to be a definitive one on the spine. The list of topics included in 43 chapters is almost all-inclusive, but coverage varies from detailed (spondylolisthesis) to skimpy (biomechanics and orthoses). There are only nine chapters in the section on operative approaches, but many other operations are described in chapters on deformities, congenital anomalies, spinal cord tumors, trauma, pain, and spondylosis (here construed to include herniated disks). A variety of orthopedic procedures to fuse the cervical spine does not include Cloward's operation. Wiltse advocates fusion for spondylolisthesis, while Gill describes removal of the loose lamina. Arumugasamy deals with rhizotomy and open cordotomy, while Davis describes percutaneous cordotomies. The respective illustrations of representation of body parts in the spinothalamic tracts are at variance. The chapter on microsurgery of the spinal cord gives no details of the use of the
MEK blockade converts AML differentiating response to retinoids into extensive apoptosis
Authors: Michele Milella, Marina Konopleva, Cristina M. Precupanu, Yoko Tabe, Maria Rosaria Ricciardi, Chiara Gregorj, Steven J. Collins, Bing Z. Carter, Carmen D'Angelo, Maria Teresa Petrucci, Robin Foà, Francesco Cognetti, Agostino Tafuri, Michael Andreeff
Journal: Blood (2006)
Mapping Out Biomarkers for Alzheimer Disease
Authors: Monique M. B. Breteler
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute Appendicitis in Pregnancy
Authors: W. P. Black
Journal: BMJ (1960)

BMrru MEDCL JOURAThe extreme degrees of oedema seen in some of the patients (especially the children with glomerulonephritis) were thought to be associated with gross hypoalbuminaemia.The cause of this was partly albuminuria, which was usually heavy (in one child, loss of urinary protein reached a level of 22 g./litre at a time when the serum albumin level was 0.49%).In some patipnts the serum albumin level continued to fall after admission to hospital, presumably because the patients were admitted early in the course of their illness before the drain of albumin in their urine had fully depleted the serum protein level.Another factor in the development of gross oedema may have been that the serum protein levels of even apparently healthy Africans in Uganda are different from European normals (Holmes, Stanier, Semambo, and Jones, 1951), the albumin levels being lower and the globulin levels higher than in Europeans.The serum albumin levels in these patients, especially in the children, were therefore probably low before the urinary loss began. SummaryThirty-three African patients suffering from glomerulonephritis were studied.In all but the youngest cases the diagnosis was confirmed by renal biopsy.The 12 children in the series presented with massive oedema and ascites associated with heavy albuminuria.Haematuria was only microscopical.A rise in blood-pressure was common.The serum albumin level was constantly low and the serum cholesterol usually raised.Electrophoresis of serum protein characteristically revealed a "nephrotic" pattern.Some rise in the blood-urea level was common in the early stages of the illness.Changes of acute nephritis were generally seen on renal biopsy, though in three out of eight cases in which this was done chronic nephritis was present.The illness ran a protracted course, abruptly curtailed in one case by steroid therapy.The overall prognosis appeared to be poor.Renal biopsy revealed acute nephritis in 6 of the 21 adult patients.One presented with the nephrotic syndrome and made an apparently good recovery.In two others with a raised blood-pressure, macroscopic haematuria, and a raised blood urea, some improvement took place in hospital.In the remaining three the disease was rapidly progressive, two dying in hospital.Severe hypertension, retinopathy, renal insufficiency, and heart failure were characteristic of these cases in which severe changes of recent origin were present on renal biopsy.Chronic nephritis was present in 10 cases, and in these hypertensive heart failure was the commonest mode of presentation.Advanced retinopathy was usual in the presence of severe hypertension.The blood urea was raised in all cases, and in four patients who died while under observation death was due to heart failure associated with insufficiency.
[341] INHIBITION OF BETA-ADRENORECEPTORS RESULTS IN DELAYED FIBROSIS IN Abcb4 KNOCKOUT MICE
Authors: I. Strack, K. Petmecky, M. Scheffler, S. Schulte, F. Lammert, H. Varnholt, H.P. Dienes, M. Odenthal
Journal: Journal of Hepatology (2007)
Gastroenterology in the Trent Region in 1992 and a review of changes since 1975.
Authors: B B Scott
Journal: Gut (1995)

A survey of all gastroenterologists in the Trent Region (population 4.7 million) showed that in 1992 the number of upper gastrointestinal endoscopies had continued to rise considerably. There were 8.6 per thousand of the population. Colonoscopies had also increased to 1.4 per thousand. There had been a large fall in barium meal examinations to 4.8 per thousand. Barium enema examinations had increased slightly to 5.3 per thousand. The number of endoscopic retrograde cholangiopancreatographies (ERCPs) and variceal sclerotherapies had also increased by 54% and 21% respectively since 1986 and were available in most of the 20 hospitals. Percutaneous endoscopic gastrostomy had been introduced at most hospitals. Emergency endoscopy was readily available at night in only half the hospitals. Fourteen hospitals offered formal open access endoscopy. Intravenous sedation was used routinely in 12 hospitals. The rate for perforation at routine upper gastrointestinal endoscopy was 1 in 4500 and for death was 1 in 20,000. There were serious deficiencies in provision of facilities or staff, or both at 14 hospitals. The total number of gastroenterologists had only increased from 25 to 26 since 1986. Thus endoscopy workload continues to increase and diversify often without adequate staffing, facilities, and funding.
Older Age, Infertility, and Multiple Pregnancies
Authors: Wendy Chavkin, Blair Johnson
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blood Culture Collection for Suspected Bacteremia—Reply
Authors: Bryan Coburn, Andrew M. Morris, Allan S. Detsky
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic Heterogeneity in Patients with Multiple Neoplastic Lung Lesions: A Report of Three Cases
Authors: Mariëlle I. Gallegos Ruiz, Hester van Cruijsen, Egbert F. Smit, Katrien Grünberg, Gerrit A. Meijer, José A. Rodriguez, Bauke Ylstra, Giuseppe Giaccone
Journal: Journal of Thoracic Oncology (2007)
Histories of Mistrust and Protectionism: Disadvantaged Minority Groups and Human-Subject Research Policies
Authors: Justin M. List
Journal: The American Journal of Bioethics (2005)

Click to increase image sizeClick to decrease image size ACKNOWLEDGEMENT I would like to thank Dr. Julius Landwirth, Associate Director of the Donaghue Initiative in Biomedical and Behavioral Research Ethics at Yale University, and Fritz Allhoff at the American Medical Association for their helpful comments on an earlier version of this paper.
REMARKS ON THE MOVEMENT OF THE DIAPHRAGM IN EARLY PULMONARY PHTHISIS
Authors: H. Walsham, W. Overend
Journal: BMJ (1915)

PULMONARY PHTHISIS.[MTi Birnm -75 3r' __5 1DCA ORA 7 In some cases of hiiglh fracture, flexion of the upper fragment of tlle femur mav be present, though this is not as comlmon in gunshot injutries as in those due ta indirect violence.For purposes of transport this will not affect the satisfactory action of the splint.In suclh cases, when the patient is stationary, the fragments can be brought into line by-bending the splint at the level of the knee as in a Hodgen's splint; The-leg slhould thereafter -be s-uspended, as in fact it -usually is during hospital treatment in straightforward cases.
Synovial lymphocytes and the aetiology of synovitis.
Authors: H Gaston
Journal: Annals of the Rheumatic Diseases (1993)

An in vitro system for the production of hepatitis B virus (HBV) particles was established by the transient expression of transfected HBV DNA using a human hepatocellular carcinoma cell, HuH-7, as a recipient. The 3.6- and 2.2-kilobase transcripts observed were similar to those in virus-infected liver cells. Both transcripts revealed the microheterogeneity of their 59 ends. The formation of virus-related particles subsequent to the RNA transcription was demonstrated. The core particles observed in the cytoplasm and the virus particles secreted in the culture medium contained the replicative intermediates of HBV DNA and banded at densities of 1.35-1.36 g/cm3 and 1.22-1.24 g/cm3, respectively. Furthermore, the in vitro mutagenesis of the template HBV DNA demonstrated that the P gene as well as the C gene products were essential for the production of HBV particles.
Asthma and Risk of the Novel 2009 H1N1 Influenza Infection in Children: A Population-Based Case-Control Study
Authors: C.F. Santillan Salas, S. Mehra, E.J. Park, B.D. Lahr, B.P. Yawn, Y.J. Juhn
Journal: Journal of Allergy and Clinical Immunology (2012)
Antihypertensive Actions of Diuretics
Authors: Bertram M. Winer
Journal: JAMA (1968)

Hydrochlorothiazide in a daily dose of 150 mg and spironolactone in a daily dose of 400 mg (100 mg of the currently available preparation) were found to have equivalent antihypertensive effects—reducing basal blood pressure, decreasing the pressor response to levarterenol bitartrate (norepinephrine) and angiotensin amide, and increasing the depressor response to a ganglion-blocking agent, trimethaphan camsylate—in a double-blind study of 11 hypertensive patients. The two diuretics, when given together, appear to act independently and additively in their antihypertensive effects. Serum potassium level, lowered by hydrochlorothiazide, was in the normal range during administration of spironolactone alone or in combination with hydrochlorothiazide. Spironolactone can thus be a useful substitute for a benzothiadiazine derivative in the treatment of hypertension. The administration of a combination of these diuretics, a thiazide and an aldosterone antagonist, can render hypertension more readily manageable.
Older women's attitudes towards breast disease, self examination, and screening facilities: implications for communication.
Authors: D S Leathar, M M Roberts
Journal: BMJ (1985)

Qualitative research techniques were used in two studies in Edinburgh to explore older women9s attitudes and motivations towards breast disease, self examination, and screening, with a view to identifying appropriate strategies for communication. The results indicated that knowledge of breast disease and screening facilities was poor and that many psychological and emotional issues inhibited self examination. Increasing information about self examination and clinics is unlikely to influence uptake unless it is presented together with emotional support rather than through conventional mass media channels. Such support may best be provided by setting breast screening within general health screening rather than emphasising the single disease.
Insanity Defense in the District of Columbia: End of an Era
Authors: William J. Curran
Journal: New England Journal of Medicine (1972)

IN 1954, Judge David Bazelon, of the United States Court of Appeals in the District of Columbia, shook the foundations of forensic psychiatry with his brilliant opinion in Durham v. U.S.1 In that case, the Court rejected the M'Naghten Rules first laid down in England in the middle of the 19th century, and adopted a modern version of the "product test" under which the jury was given no legal standard of responsibility but was allowed to acquit defendants whose otherwise criminal acts were the product of medically determined "mental illness." This test was not original with Judge Bazelon: it had . . .
Reentrant Pathway During Ventricular Echoes Is Confined to the Atrioventricular Node
Authors: Peter Loh, Jacques M. T. de Bakker, Mélèze Hocini, Bernard Thibault, Richard N. W. Hauer, Michiel J. Janse
Journal: Circulation (1999)

Background —During ventricular echoes, reentrant excitation is supposed to involve 2 functionally distinct pathways in the atrioventricular (AV) nodal area. The exact pathway of reentrant excitation is unknown. The objectives of this study were to analyze electrical activity in the AV nodal area after ventricular stimulation and during ventricular echoes and to assess the role of perinodal atrial tissue in AV nodal reentry. Methods and Results —In 16 isolated, blood-perfused canine hearts, multiterminal electrodes were used to map electrical activity in Koch’s triangle after ventricular stimulation and during ventricular echoes. The subendocardial cell layers were chemically destroyed in 3 hearts. Incisions in the posterior approach to the compact node were made in 6 hearts. The apex of the triangle of Koch was surgically dissociated from the perinodal atrial tissue in 5 hearts. Retrograde atrial activation occurred via 2 distinct endocardial exit sites. Ventricular echoes could be induced in all hearts irrespective of the atrial activation pattern. Simultaneous retrograde activation of both exit sites often preceded reciprocation. Ventricular echoes were demonstrable after chemical destruction of the endocardium and after surgical dissociation of the perinodal atrial tissue from the AV node. Conclusions —Our data show that the reentrant pathway during ventricular echoes is confined to the AV node. The tissue that connects the node to the endocardial exit sites has to be excluded from the reentrant circuit responsible for single echoes.
Comparison between emission and transmission computed tomography of the liver.
Authors: O Khan, P J Ell, P H Jarritt, I D Cullum, E S Williams
Journal: BMJ (1981)

Emission computed tomography (emission CT) and conventional planar gamma-camera imaging of the liver were compared in 242 patients with suspected metastatic spread to liver. Concordant data were obtained in 171 patients (71%). Single large lesions, multiple small lesions, and diffuse disease were accurately defined with this new radionuclide tomographic technique. The smallest lesion detected by emission CT was 8 mm. Emission CT, planar gamma-camera imaging, and transmission (x-ray) CT were compared in 107 patients. All three methods gave identical results in 76 patients (71%). Assessed against other criteria, such as histological findings and follow-up data, emission CT yielded the highest range of accuracy (92-96%), while transmission CT and planar gamma-camera imaging had similar but lower accuracies (78-81%). Emission CT had a false-positive rate of 2.8% and a false-negative rate of less than 1%. Thus emission CT is highly sensitive in detecting space-occupying disease in the liver.
Rubella vaccination of schoolgirls: factors affecting vaccine uptake.
Authors: C S Peckham, W C Marshall, J A Dudgeon
Journal: BMJ (1977)

In a national sample of 16-year-old girls who were aged 12 when the rubella vaccine programme was implemented in 1970, 71% were reported to have received rubella vaccine. There was a high regional disparity in the uptake of rubella vaccine: 81% of girls living in Scotland had been vaccinated but only 61% of girls living in Wales. Similarly there was a difference in reported vaccine uptake according to the family social background, the lowest proportion vaccinated came from professional and unskilled manual families. Girls attending independent schools also had a lower vaccine uptake than girls in schools maintained by the local educational authorities. If rubella immunisation is to be effective uptake of vaccine must increase to almost 100%.