Anaphylactoid Reactions after Indocyanine-Green Administration
Authors: Rudolf Speich, Barbara Saesseli, Ulrich Hoffmann, Klaus A. Neftel, Juerg Reichen
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 August 1988Anaphylactoid Reactions after Indocyanine-Green AdministrationRudolf Speich, MD, Barbara Saesseli, MD, Ulrich Hoffmann, MD, Klaus A. Neftel, MD, Juerg Reichen, MDRudolf Speich, MDSearch for more papers by this author, Barbara Saesseli, MDSearch for more papers by this author, Ulrich Hoffmann, MDSearch for more papers by this author, Klaus A. Neftel, MDSearch for more papers by this author, Juerg Reichen, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-4-345_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Indocyanine-green is used for determination of cardiac output, liver function testing, chorioidal angiography, and capillary microscopy. We report three cases of patients with anaphylactoid reactions to indocyanine-green, which together with reports in the literature suggest a dose-dependent pseudoallergic mechanism, rather than a true immune mechanism.A 49-year-old man received indocyanine-green, 5 mg/kg body weight for capillary microscopy. Within 10 seconds, he developed flush, dyspnea, and shock.A 56-year-old man received indocyanine-green, 0.5 mg/kg for liver function testing. Within 1 minute, he developed acute bronchospasm, hypotension, and cardiorespiratory arrest.A 62-year-old man received indocyanine-green, 0.5 mg/kg for liver...References1. MichieWomboltCarrettaZenckaEgan DDRAJ. Adverse reactions associated with the administration of a tricarbocyanine dye (Cardio-green) to uremic patients. J Allergy Clin Immunol. 1971;48:235-9. CrossrefMedlineGoogle Scholar2. CarskiStallerHepnerBankaFinney TBGVR. Adverse reactions after administration of indocyanine-green. JAMA. 1978;240:635. CrossrefGoogle Scholar3. IwamuraYamanakaYamanakaNishikawa KITH. A case of complication due to indocyanine-green test. Jap J Gastroenterology. 1974;71:573-8. MedlineGoogle Scholar4. NanikawaHayashiHayashiHashimotoAmeno RTKYK. A case of fatal shock induced by indocyanine-green (ICG) test. Jap J Legal Med. 1978;32:209-14. Google Scholar5. IsekiOnoyamaFujimiOmae KKST. Shock caused by indocyanine-green dye in chronic hemodialysis patients. Clin Nephrol. 1980;14:210. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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Juan-Carlos García-Pagán, MD, Faust Feu, MD, Miguel Navasa, MD, Jaime Bosch, MD 15 August 1988Volume 109, Issue 4Page: 345-346KeywordsAngiographyBody weightCapillariesCardiac outputDyspneaHypotensionLiverLiver function testsMicroscopyShock Issue Published: 15 August 1988 PDF downloadLoading ...