tbuckley/cabot-search huggingface dataset:
EPIDEMIOLOGICAL STUDIES ON RESPIRATORY INFECTIONS OF THE RABBIT
Authors: Leslie T. Webster
Journal: The Journal of Experimental Medicine (1927)

The spread of Bact. lepisepticum infection throughout a population of thoroughbred rabbits at a farm in New City, N. Y., was studied over a period of 2 years. The following observations are noteworthy. 1. 50 to 75 per cent of the total mortality was due to Bact. lepisepticum infection. 2. About 50 per cent of the stock was affected locally with Bact. lepisepticum "snuffles." 3. "Snuffles" and mortality rates showed spring and fall rises and low points during the summer. 4. Carrier, morbidity, and mortality rates of various special breeds differed consistently and to a marked degree. All reflected the same seasonal fluctuations as the total population. 5. Individuals within each breed differed in their response to the presence of Bact. lepisepticum; some died of penumonia and septicemia; others developed the local nasal infection, "snuffles"; others became "healthy" carriers; and a few remained uninfected.
Vascular Effects Following Homozygous Disruption of p47 <sup>phox</sup>
Authors: Eileen Hsich, Brahm H. Segal, Patrick J. Pagano, Federico E. Rey, Beverly Paigen, John Deleonardis, Robert F. Hoyt, Steven M. Holland, Toren Finkel
Journal: Circulation (2000)

Evidence suggests that the vessel wall contains an oxidase similar, if not identical, to phagocytic NADPH oxidase. We tested the contribution of this specific oxidase to the progression of atherosclerosis and the regulation of blood pressure.An examination of aortic rings from wild-type mice and mice with homozygous targeted disruptions in p47(phox) revealed that p47(phox) knockout mice had a reduction in vascular superoxide production. However, analyses of apoE -/- p47(phox)+/+ and apoE -/- p47(phox) -/- strains of mice demonstrated no significant differences in atherosclerotic lesion sizes. Similarly, analyses of wild-type and p47(phox) knockout mice revealed no differences in either basal blood pressure or the rise in blood pressure seen after the pharmacological inhibition of nitric oxide synthase.NADPH oxidase contributes to basal vascular superoxide production. However, the absence of a functional oxidase does not significantly affect the progression of atherosclerosis in the standard mouse apoE -/- model, nor does it significantly influence basal blood pressure.
Hyperpigmentation due to topical calcipotriol and photochemotherapy in two psoriatic patients
Authors: None GLAser, None ROwert, None Mrowietz
Journal: British Journal of Dermatology (1998)

The vitamin D3 analogue calcipotriol (calcipotriene) is an effective topical treatment for psoriasis. In combination with other antipsoriatic agents, such as ultraviolet radiation, calcipotriol is reported to improve the overall efficacy of the treatment. Here we describe two patients treated with a combination treatment of calcipotriol and bath psoralens and ultraviolet A who developed hyperpigmentation at the lesional sites where calcipotriol ointment was applied.
A Questionnaire-based Study to Assess Parents' Perception of Food Allergy in Pre-school Children
Authors: S KHAN, S KAPOOR, V ALLGAR, W SEWELL
Journal: Journal of Allergy and Clinical Immunology (2008)

Food allergy has the highest prevalence in pre-school (aged 3-5 years) children. However, allergy is often self-diagnosed by parents without formal medical involvement. We decided to assess parents' views of food allergy in their children by using a validated questionnaire. Questionnaires were distributed among seven local schools in the Scunthorpe area. Questions were asked about the presence of allergy, symptoms, allergens, method of diagnosis and treatment. 264 replies (36% response rate) were received and 11.4% of the parents reported their children to have food allergy. The commonest foods attributed were cow's milk (20%), peanut (20%), egg (10%), fish and shellfish (10%), soya (10%), food colourings (13%) and preservatives (23%). The symptoms reported were rash (60%), swelling (27%), diarrhea (23%), wheeze (13%). Allergy was blamed by parents in 30% of cases because of symptoms of irritability (20%), hyperactivity (26%) and behavioural problems (3%). 40% of these were self-diagnosed (no medical input), and all were being managed by food avoidance. Of those seeking advice, 50% of parents' received advice from their general practitioner, 30% from health visitor and 26% were referred to Hospital and investigated (paediatrician/allergist services). There was a trend towards implicating more foods and more symptoms as allergies with higher maternal education and thus higher erroneous self-diagnosis of food allergy. Parental self-diagnosis of 'food allergy' is common and is frequently associated with inappropriate dietary manipulation and failure to seek appropriate medical advice. As allergy services are available in the area, the problem is therefore one of inadequate public education.
Role of immune stimulation in the etiology of multiple myeloma: A case control study
Authors: Harvey Jay Cohen, Rosyln Julie Bernstein, Seymour Grufferman
Journal: American Journal of Hematology (1987)

Abstract As hospital‐based case‐control study of 153 multiple myeloma (MM) cases and 459 controls was conducted to evaluate the hypothesis that chronic or frequent infections or allergic and autoimmune diseases might be of higher prevalence in individuals who develop MM. Information was obtained by direct interviews of subjects. Controls were matched to cases on age, sex, race, and hospital. “Immune‐stimulating conditions” included chronic infections such as pyelonephritis, urinary tract infections (UTIs), prostatitis, rheumatoid arthritis and other collagen vascular diseases, allergies, bronchitis, tuberculosis, cholecystitis, diverticulitis, and osteomyelitis. The overall odds ratio (OR) (odds of history of immune‐stimulating conditions in cases versus controls) was 0.4 (95% confidence interval = 0.3 − 0.7) which suggested that cases had significantly less immune‐stimulating conditions than did controls. The exposure rate for these conditions was high for cases (0.7) as well as for all control groups (0.8). These findings suggest that immune‐stimulating conditions alone are not the causative factor in the etiology of MM, though they may play a role in the predisposed individual.
VARIABILITY AND UNRELIABILITY IN THE DETERMINATION OF THE OPSONIC INDEX.
Authors: BENJAMIN A. THOMAS
Journal: JAMA (1907)

Huxley has said, "The man of science has learned to believe in justification, not by faith, but by verification." With this in mind, throughout the past nine months, I have been engaged in a study of the practical utility of the opsonic index as a factor in the diagnosis, prognosis and therapeusis of disease. Lest my attitude on this question be misinterpreted, I desire primarily to state that I have no reason to doubt, and, on the contrary, entertain implicit faith in the theory of opsonins; but as to the practicability of the index in medicine, my experiments have occasioned the gravest skepticism, if not absolute pessimism, relative to its utility for the profession at large. Slow as the perfection of the delicate technic for the determination of the phagocytic power of the blood necessarily was, it is rather surprising to note that approximately but one year has elapsed since
Disease progression in patients with thin cutaneous melanomas (tumour thickness &lt;= 0.75 mm): clinical and epidemiological data from the Tumour Center Munich 1977-98
Authors: M-H. Schmid-Wendtner, J. Baumert, J. Eberle, G. Plewig, M. Volkenandt, C.A. Sander
Journal: British Journal of Dermatology (2003)

Background Although survival in patients with thin melanomas (tumour thickness ≤ 0·75 mm) is usually excellent, thin melanomas have the potential to metastasize. Objectives To determine risk factors for the development of disease progression in patients with thin cutaneous melanomas. Methods A retrospective study was performed between 1977 and 1998 to identify risk factors for the development of disease progression in 2302 patients with cutaneous melanoma with tumour thickness ≤ 0·75 mm, diagnosed and treated at the Department of Dermatology and Allergology, Ludwig-Maximilians University, Munich, Germany. The Kaplan–Meier method was used to estimate the influence of different clinical characteristics for the occurrence of first progression during 10 years of follow-up. Results An analysis of the data from 6298 patients with cutaneous melanoma identified 2302 patients (37%) who presented with cutaneous melanoma with a tumour thickness ≤ 0·75 mm, without clinical signs of metastasis at initial diagnosis (clinical stage Ia). A small subgroup of our patients (77 of 2302) developed metastatic disease during the follow-up period. The estimated rate of occurrence of metastasis after 10 years of follow-up was 4·7%. The mean follow-up time was 62 months (median 46). Of these 77 patients, 16 experienced progression at the primary tumour site and 32 presented with regional lymph node metastases. Twenty-eight patients primarily developed systemic metastases (seven patients with and 20 without regional lymph node metastases, one patient with regional lymph node metastases and local recurrence). In one patient the primary site of metastatic disease was not reported. Clinical characteristics included age, sex of the patient and different subtypes of cutaneous melanoma: superficial spreading melanoma, nodular melanoma, acrolentiginous melanoma (ALM) and lentigo maligna melanoma (LMM). Male patients and patients with LMM or ALM were significantly over-represented (P = 0·02 and P = 0·002). In the group of 77 patients with thin melanomas (≤ 0·75 mm), local recurrence was over-represented as compared with those with melanomas > 0·75 mm. No difference in group was found for overall survival after the occurrence of lymph node metastasis as the first manifestation of disease progression. Conclusions Thorough follow-up and skin examination is recommended for a subgroup of patients with thin tumours, which consists of male patients with LMM or ALM located in the head and neck region.
Feedback suppression of the immune response in vitro. II. IgVH-restricted antibody-dependent suppression.
Authors: R H Zubler, B Benacerraf, R N Germain
Journal: The Journal of Experimental Medicine (1980)

Feedback suppression of the primary humoral immune response to sheep erythrocytes (SRBC) in vitro was induced with cell-free supernate material derived from antigen-(SRBC) activated B (sIg+) cells. This soluble products bears Ig determinants and binds to the eliciting antigen (SRBC). The activity of this antibody in suppressing anti-SRBC plaque-forming cell responses is restricted to spleen cell cultures containing B cells sharing VH genes with the B cells producing the suppressive antibody. The anti-hapten (trinitrophenyl) response to derivatized SRBC is not affected by antigen-primed B cells or their products. These data are compatible with suppression being mediated by anti-antigen antibody, either (a) via blockade of different SRBC epitopes recognized by a limited set of B cell clones in each mouse strain, (b) via triggering of an anti-idiotypic response, either antibody or suppressor T cell in nature, restricted to activity in cultures containing B cells sharing VH structures with the original antibody, or (c) via interference by preformed antibody with T cell help directed at idiotype bearing B cells.
Multiple myeloma: comparison of two dose-intensive melphalan regimens (100 vs 200 mg/m2)
Authors: A Palumbo, S Bringhen, A Bertola, F Cavallo, P Falco, M Massaia, B Bruno, C Rus, A Barbui, T Caravita, P Musto, N Pescosta, F Rossini, M Vignetti, M Boccadoro
Journal: Leukemia (2003)
519 Long-term occurrence of liver complications in hepatitis C patients. Association with host and viral factors
Authors: P. Pradat, H.L. Tillmann, R. Goldin, J. Langer, M. Thursz, S. Sauleda, G. Saracco, P. Merle, S. Badalamenti, A. Alberti, J.H. Braconier, J.I. Esteban, S. Hadziyannis, M. Rizzetto, H.C. Thomas, M.P. Manns, C. Trepo
Journal: Journal of Hepatology (2004)
The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1
Authors: Maria de la Luz Sierra, Shuhei Sakakibara, Paola Gasperini, Ombretta Salvucci, Kan Jiang, Peter J. McCormick, Marta Segarra, Jim Stone, Dragan Maric, Jinfang Zhu, Xiaolan Qian, Douglas R. Lowy, Giovanna Tosato
Journal: Blood (2010)
Ketoconazole and Blastomycotic Osteomyelitis
Authors: KATHY CLAFLIN
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 February 1983Ketoconazole and Blastomycotic OsteomyelitisKATHY CLAFLIN, M.D., JOHN MILBAUER, M.D., BRADLEY SULLIVAN, M.D.KATHY CLAFLIN, M.D.Search for more papers by this author, JOHN MILBAUER, M.D.Search for more papers by this author, BRADLEY SULLIVAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-2-260_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A 13-year-old boy was hospitalized for evaluation of arthritis of 2 weeks' duration, and pneumonia of 3 months' duration. The pneumonia had been treated with several antibiotics with partial resolution. The patient lost 9 kg of weight while he had pneumonia.Three weeks before admission the boy had developed pain, erythema, and swelling of the metatarsal-phalangeal joint of his left great toe, followed 1 week later by swelling in the left knee and right elbow. One week before admission he had had swelling and tenderness of the fourth proximal interphalangeal joint of his left hand.Positive physical...References1. MITCHELL T. Blastomycosis. In: FEIGIN RD, CHERRY JD, eds. Textbook of Pediatric Infectious Diseases. Philadelphia: W. B. Saunders; 1981:1478-88. Google Scholar2. HARVEYISENBERGSTEVENS RRD. Molecular modifications of imidazole compounds: studies of activity and synergy in vitro and of pharmacology and therapy of Blastomycosis in a mouse model. Rev Infect Dis. 1980;2:559-69. CrossrefGoogle Scholar3. DUNBARPYLE MR. Ketoconazole treatment of osseous blastomycosis in a dog. Ved Med (Praha). 1981; 1593. Google Scholar4. EDSONKEYS RT. Treatment of primary pulmonary blastomycosis: results of long-term follow-up. Mayo Clin Proc. 1981;56:683-5. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Marshfield Clinic Marshfield, WI 54449 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBlastomycosis of Bones and JointsSubcutaneous Blastomycosis: Diagnosis by Fine-Needle Aspiration CytologyIsolated blastomycotic osteomyelitis: A case simulating a malignant tumor of the distal radiusKetoconazole Therapy for Endemic BlastomycosisROBERT W. BRADSHER, M.D., DAN C. RICE, M.D., ROBERT S. ABERNATHY, M.D.Blastomycotic osteomyelitis of the mandible: Successful treatment with ketoconazoleBlastomycosis presenting as monarticular arthritis. The role of synovial fluid cytologyKetoconazole; Mechanism of Action, Spectrum of Activity, Pharmacokinetics, Drug Interactions, Adverse Reactions and Therapeutic UseKetoconazole: An Orally Effective Antifungal Agent Mechanism of Action, Pharmacology, Clinical Efficacy and Adverse EffectsKetoconazole 1 February 1983Volume 98, Issue 2Page: 260-261KeywordsAntibioticsArthralgiaArthritisElbowErythemaInflammationKneesOsteomyelitisPneumonia Issue Published: 1 February 1983 PDF downloadLoading ...
Age and Effectiveness of Implantable Cardioverter-Defibrillators
Authors: Pasquale Santangeli, Luigi Di Biase, Andrea Natale
Journal: Annals of Internal Medicine (2011)

Letters2 August 2011Age and Effectiveness of Implantable Cardioverter-DefibrillatorsPasquale Santangeli, MD, Luigi Di Biase, MD, PhD, and Andrea Natale, MDPasquale Santangeli, MDFrom Catholic University of the Sacred Heart, 00168 Rome, Italy, and Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, TX 78705.Search for more papers by this author, Luigi Di Biase, MD, PhDFrom Catholic University of the Sacred Heart, 00168 Rome, Italy, and Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, TX 78705.Search for more papers by this author, and Andrea Natale, MDFrom Catholic University of the Sacred Heart, 00168 Rome, Italy, and Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, TX 78705.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-3-201108020-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:In response to Dr. Braunschweig and Dr. Wedel, we have modified the inclusion criteria by including the MADIT-II population older than 70 years. In this way, a small ICD survival benefit in elderly patients was detected (hazard ratio, 0.75 [95% CI, 0.61 to 0.91]; number needed to treat for benefit, 24 [CI, 16 to 67]). However, we wish to clarify that such benefit was entirely driven by inclusion of MADIT-II patients older than 70 years, who constituted a minority (436 out of 2414 patients, or 18%) of the elderly population included in the meta-analysis. This benefit also was ... Author, Article, and Disclosure InformationAffiliations: From Catholic University of the Sacred Heart, 00168 Rome, Italy, and Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, TX 78705.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M10-0999. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-analysis: Age and Effectiveness of Prophylactic Implantable Cardioverter-Defibrillators Pasquale Santangeli , Luigi Di Biase , Antonio Dello Russo , Michela Casella , Stefano Bartoletti , Pietro Santarelli , Gemma Pelargonio , and Andrea Natale Age and Effectiveness of Implantable Cardioverter-Defibrillators Frieder Braunschweig and Hans Wedel Metrics 2 August 2011Volume 155, Issue 3Page: 201-202KeywordsConflicts of interestDisclosureElderlySurvival analysis ePublished: 2 August 2011 Issue Published: 2 August 2011 CopyrightCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Uricosuric Effect of Chlorprothixene
Authors: Louis A. Healey, Mary Harrison, John L. Decker
Journal: New England Journal of Medicine (1965)

IN the course of a survey of the serum uric acids of patients in a state mental hospital it was noted that the mean level of 14 patients receiving the tranquilizing drug chlorprothixene¶ was significantly lower than the mean for the remainder of the patients whether or not they were receiving drugs. The mean serum uric acid for the entire population was 5.4 mg. per 100 ml. All but 1 of the patients taking chlorprothixene had levels below this figure, and the mean was 3.2 mg. per 100 ml. Seven of 8 patients who had been taking at least 250 . . .
Discharges from nursing homes
Authors: J Henry, I MacPherson, S Donald
Journal: BMJ (1994)

EDITOR, - Clive E Bowman may be correct in stating that there are inadequacies in the medical care for residents of nursing homes. Our survey, however, was designed not to study the care provided in nursing homes but to monitor discharges from nursing homes over three years. Bowman is correct to highlight the importance of inappropriate placement, but, again, our survey was not designed to study this. If people are being placed inappropriately this …
Bone Density and Body Weight in Hyperparathyroidism
Authors: Jesse C. Krakauer
Journal: Annals of Internal Medicine (1995)

Letters15 May 1995Bone Density and Body Weight in HyperparathyroidismJesse C. KrakauerJesse C. KrakauerSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-10-199505150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Grey and colleagues [1] used dual-energy x-ray absorptiometry to support a change in our thinking about primary hyperparathyroidism. Unfortunately for clinicians in the United States, the Food and Drug Administration has forced the withdrawal of body-composition output from x-ray absorptiometry instruments pending additional licensing. Grey and colleagues based their conclusions on a complete (except forearm scans) acquisition of x-ray absorptiometry data from a cohort of patients and age-matched controls. They presented the bone mineral density results as unadjusted and weight-adjusted values in g/cm2 on a single scale for the site-specific (lumbar spine, femur) and total body scans ...References1. Grey AB, Evans MC, Stapleton JP, Reid IR. Body weight and bone mineral density in postmenopausal women with primary hyperparathyroidism. Ann Intern Med. 1994; 121:745-9. Google Scholar2. Reid IR, Evans MC, Stapleton J. Lateral spine densitometry is a more sensitive indicator of glucocorticoid-induced bone loss. J Bone Miner Res. 1992; 7:1221-5. Google Scholar Author, Article, and Disclosure InformationAuthors: Jesse C. Krakauer PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1995Volume 122, Issue 10Page: 801KeywordsBody weightBone densityData acquisitionFemurFood and Drug AdministrationHyperparathyroidismOsteopeniaPhoton absorptiometrySkeletonSpine ePublished: 15 August 2000 Issue Published: 15 May 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Hyperplasia of Autotransplanted Parathyroid in the Forearm
Authors: SHIGEO TAKEBAYASHI, KENGO MATSUI, TAKEO NOZAWA, EIICHI FUJIOKA, HIDEO HIDAI
Journal: Clinical Nuclear Medicine (1990)

A TI-201 chloride forearm image showed an area of increasing activity in a 45-year-old woman who had undergone total parathyroidectomy and autoplantation of minced parathyroid in the forearm for secondary hyperparathyroidism. This increasing activity corresponded to enlarged implanted parathyroid and indicated development of recurrent secondary hyperparathyroidism.
Nifedipine for Hypertensive Emergencies
Authors: P. J. Kelly
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The article by Dr Grossman and colleagues<sup>1</sup>documents several important points regarding the treatment of hypertensive emergencies and urgencies. The myth of the superiority of sublingual over oral nifedipine is dispelled nicely, and the adverse effects of sublingual nifedipine are equally well illustrated. The concept of a pseudoemergency, in which there is asymptomatic, excessive elevation of blood pressure, is presented to emphasize the prudence in not treating these patients aggressively. However, the conclusion to abandon the routine use of short-acting nifedipine capsules in hyper
A double blind controlled trial of prednisolone-21-phosphate suppositories in the treatment of idiopathic proctitis
Authors: J. E. Lennard-Jones, J. H. Baron, A. M. Connell, F. A. Jones
Journal: Gut (1962)

A double blind trial of prednisolone suppositories in out-patients with idiopathic proctitis is reported. Significant improvement was noted. When prednisolone suppositories were given after the patient had already used suppositories of base alone for three weeks the active treatment was no longer so effective.