Update in Cardiology: Evidence Published in 2013
Authors: Carl J. Pepine
Journal: Annals of Internal Medicine (2014)

Updates17 June 2014Update in Cardiology: Evidence Published in 2013Carl J. Pepine, MDCarl J. Pepine, MDFrom the University of Florida, Gainesville, Florida.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M14-0300 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This update summarizes key articles in cardiovascular disease (CVD) published in 2013 (and 1 published on 14 January 2014 that explains reasons for disagreement with another article). These reports were selected because of their potential effect on clinical practice. Specifically, they foster the American College of Physicians’ “high-value care” initiative to encourage physicians to focus on diagnostic and management strategies that balance clinical benefit with cost and harm with the goal of improving patient outcomes. Advances were particularly significant in the fields of hypertension, with multiple new guidelines for management focusing on prevention and anticoagulation to prevent stroke in atrial ...References1. Egan BM, Zhao Y, Axon RN, Brzezinski WA, Ferdinand KC. Uncontrolled and apparent treatment resistant hypertension in the United States, 1988 to 2008. Circulation. 2011;124:1046-58. [PMID: 21824920] CrossrefMedlineGoogle Scholar2. Mancia G, Fagard R, Narkiewicz K, Redón J, Zanchetti A, Böhm M, et al; Task Force Members. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2013;31:1281-357. [PMID: 23817082] CrossrefMedlineGoogle Scholar3. Weber MA, Schiffrin EL, White WB, Mann S, Lindholm LH, Kenerson JG, et al. Clinical practice guidelines for the management of hypertension in the community: a statement by the American Society of Hypertension and the International Society of Hypertension. J Clin Hypertens (Greenwich). 2014;16:14-26. [PMID: 24341872] CrossrefMedlineGoogle Scholar4. Ruff CT, Giugliano RP, Braunwald E, Hoffman EB, Deenadayalu N, Ezekowitz MD, et al. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet. 2013;:. [PMID: 24315724] MedlineGoogle Scholar5. Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, et al; RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361:1139-51. [PMID: 19717844] CrossrefMedlineGoogle Scholar6. Patel MR, Mahaffey KW, Garg J, Pan G, Singer DE, Hacke W, et al; ROCKET AF Investigators. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011;365:883-91. [PMID: 21830957] CrossrefMedlineGoogle Scholar7. Granger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, et al; ARISTOTLE Committees and Investigators. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365:981-92. [PMID: 21870978] CrossrefMedlineGoogle Scholar8. Giugliano RP, Ruff CT, Braunwald E, Murphy SA, Wiviott SD, Halperin JL, et al; ENGAGE AF-TIMI 48 Investigators. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2013;369:2093-104. [PMID: 24251359] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Carl J. Pepine, MDAffiliations: From the University of Florida, Gainesville, Florida.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M14-0300.Corresponding Author: Carl J. Pepine, MD, University of Florida, 1600 Southwest Archer Road, Box 100277, Gainesville, FL 32610-0277; e-mail, Carl.Pepine@medicine.ufl.edu.Author Contributions: Conception and design: C.J. Pepine.Analysis and interpretation of the data: C.J. Pepine.Drafting of the article: C.J. Pepine.Critical revision of the article for important intellectual content: C.J. Pepine.Final approval of the article: C.J. Pepine.Collection and assembly of data: C.J. Pepine.This article was published online first at www.annals.org on 10 April 2014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 June 2014Volume 160, Issue 12Page: 847-852KeywordsAnticoagulantsAtherosclerotic cardiovascular diseaseCardiovascular diseasesDenervationHemorrhageHypertensionPercutaneous coronary interventionStatinsStrokeTreatment guidelines ePublished: 17 June 2014 Issue Published: 17 June 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...