Acute Renal Failure Due to Inhalation of Trichlorethylene
Authors: C. F. GUTCH
Journal: Annals of Internal Medicine (1965)

Case Studies1 July 1965Acute Renal Failure Due to Inhalation of TrichlorethyleneC. F. GUTCH, M.D., F.A.C.P., W. G. TOMHAVE, M.D., S. C. STEVENS, PH.D.C. F. GUTCH, M.D., F.A.C.P., W. G. TOMHAVE, M.D., S. C. STEVENS, PH.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-1-128 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis report presents an unusual case of poisoning due to trichlorethylene. The patient described below developed both kidney and cardiac damage after inadvertent inhalation of this agent. The chemical and the circumstances of the exposure were unknown at first.Trichlorethylene has had considerable use as an anesthetic agent, particularly in obstetrical work. Its industrial uses as a degreasing and extracting agent, solvent in dry cleaning and textile work, vehicle for rubber and plastic cements, and numerous applications in the chemical industry are less familiar to most physicians.Having the formula CHCl = C Cl2, trichlorethylene is related chemically to carbon...References1. BALSLOVJORGENSEN JTHE: A survey of 499 patients with acute anuric renal insufficiency. Amer. J. Med. 34: 753, 1963. CrossrefMedlineGoogle Scholar2. BROWNING E: Toxicity of Industrial Solvents, Chemical Publishing Company, Inc., New York, 1953, p. 169. Google Scholar3. VONOETTINGEN WF: The halogenated hydrocarbons: their toxicity and potential dangers. J. Industr. Hyg. 19: 349, 1937. Google Scholar4. KLEINFELDTABERSHAW MIR: Trichlorethylene toxicity—report of 5 fatal cases. Arch. Industr. Hyg. 10: 134, 1954. Google Scholar5. DEFALQUE RJ: Pharmacology and toxicology of trichlorethylene. Clin. Pharmacol. Ther. 2: 665, 1961. CrossrefMedlineGoogle Scholar6. MAHER JF: Personal communication. Google Scholar7. MERRILL JP: Personal communication. Google Scholar8. SURAWICZ B: Electrolytes and the electrocardiogram. Mod. Conc. Cardiov. Dis. 33: 875, 1964. MedlineGoogle Scholar9. BARSOUMSAAD GSK: Relative toxicity of certain chlorine derivatives of the aliphatic series. Quart. J. Pharm. 7: 205, 1934. Google Scholar10. OSTLERE G: Trichlorethylene Anaesthesia, E. and S. Livingstone, Ltd., Edinburgh and London, 1953, p. 26. Google Scholar11. WATERSORTHGILLESPIE RMOSNA: Trichlorethylene anesthesia and cardiac rhythm. Anesthesiology 4: 1, 1943. CrossrefGoogle Scholar12. BARNESIVES CGJ: EKG changes during trilene anesthesia. Proc. Roy. Soc. Med. 37: 528, 1944. CrossrefGoogle Scholar13. GRANDJEANMÜNCHINGERTURRIANHAASKNOEPFELROSENMUND ERVPAHKH: Investigations into the effects of exposure to trichlorethylene in mechanical engineering. Brit. J. Industr. Med. 12: 131, 1955. MedlineGoogle Scholar14. : Chemical Safety References, data sheet 486 (revised), National Safety Council, Chicago, 1962. Google Scholar15. : Hazardous Substances, part 191.7, 29 Federal Register 1802 (amend. Feb. 4, 1964). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Lincoln, NebraskaFrom the Medical Service and Dialysis Unit, Veterans Administration Hospital, Lincoln, Nebr.Requests for reprints should be addressed to C. F. Gutch, M.D., 6015 Sumner, Lincoln, Nebr. 68506. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNephrotoxicity of Lithium and Drugs of AbuseChlorinated HydrocarbonsNephrotoxicity of organic solvents from skin exposureTrichlorethylen [MAK Value Documentation in German language, 1977]Nephrotoxicity of Lithium and Drugs of AbuseHalogenated HydrocarbonsUses of and Exposure to Trichloroethylene in U.S. Industry: A Systematic Literature ReviewEncephalopathy and cranial nerve palsies caused by intentional trichloroethylene inhalationThe Electromagnetic Spectrum and Chemical HazardsOccupational hydrocarbon exposure and chronic nephropathyTrichloroethylene exposure in vapour degreasing and the urinary excretion of N-acetyl-β-d-glucosaminidaseAcute renal failure due to trichloroethylene poisoning.Minnesota highway maintenance worker cohort mortality study: Methods and noncancer mortalityStudies of acute nephrotoxic potential of trichloroethylene in fischer 344 ratsToxicity in man due to stain removers containing 1,2-dichloropropane.Possibilities of detecting health effects by studies of populations exposed to chemicals from waste disposal sites.Oral and intravenous trichloroethylene pharmacokinetics in the ratIncreased urinary enzyme excretion in workers exposed to nephrotoxic chemicalsCongestive Cardiomyopathy due to Chronic Inhalation of TrichlorethyleneChronic Dysphagia and Trigeminal Anesthesia After Trichloroethylene ExposureWILLIAM H. LAWRENCE, M.D., EDWARD K. PARTYKA, M.D.Development of an animal model of solvent abuse for use in evaluation of extreme tricholoroethyylene inhalationRenal response to environmental toxicsTrichlor�thylen-, Tetrachlorkohlenstoff- und Benzinintoxikation als �tiologischer Faktor bei der Entstehung der Arterio- bzw. KoronarskleroseToxicologic and Cancerogenic Evaluation of Chemicals Used in the Graphic Arts IndustriesTOXIC LIVER INJURIESSolvent sniffing deathCardiotoxische Wirkungen von Trichlor�thylenA time-saving procedure for the determination of total trichloro-compounds in human urine samplesCentrilobular Hepatic Necrosis and Acute Renal Failure in "Solvent Sniffers"RICHARD D. BAERG, M.D., DANIEL V. KIMBERG, M.D.Hepatorenal toxicity from sniffing spot-remover (trichloroethylene)Experimental Human Exposure to Trichloroethylene 1 July 1965Volume 63, Issue 1Page: 128-134KeywordsChemical analysisElectrocardiographyFood and Drug AdministrationInhalationKidneysMedical dialysisMedical servicesMyocarditisResearch laboratoriesSafety Issue Published: 1 July 1965 PDF DownloadLoading ...