tbuckley/cabot-search huggingface dataset:
Decreased survival of subjects with elevated liver function tests during a 28-year follow-up
Authors: Cecilia Söderberg, Per Stål, Johan Askling, Hans Glaumann, Greger Lindberg, Joel Marmur, Rolf Hultcrantz
Journal: Hepatology (2009)

The long-term survival of subjects with nonalcoholic fatty liver disease (NAFLD) in comparison with both individuals with elevated transaminases attributable to other causes and the general poulation is poorly characterized. This study was undertaken to determine the frequency of NAFLD in a cohort of subjects who underwent liver biopsy from 1980 to 1984 because of elevated liver enzymes, and to assess mortality among subjects with NAFLD in comparison with the general Swedish population. The 256 subjects (61% men) had a mean age of 45 +/- 12 years at the inclusion. Liver biopsies were blindly scored for NAFLD and nonalcoholic steatohepatitis (NASH). Causes of death were ascertained from the national Swedish Cause of Death Registry. Fatty liver was detected in 143 of the 256 subjects, including 25 (10%) with alcoholic fatty liver disease and 118 (46%) exhibiting NAFLD. Of those, 51 (20%) were classified as NASH and 67 (26%) as nonalcoholic bland steatosis. Cirrhosis was present in 9% at inclusion. During the follow-up period, 113 (44%) of the total population and 47 (40%) of the 118 subjects diagnosed with NAFLD died. Of the 113 deaths, 37 were of cardiovascular disease and 16 of liver diseases. Compared with the total Swedish population, adjusted for sex, age, and calendar period, subjects with NAFLD exhibited a 69% increased mortality (standardized mortality ratio [SMR] = 1.69; 95% confidence interval [CI], 1.24-2.25); subjects with bland steatosis, a 55% increase (SMR, 1.55; 95% CI, 0.98-2.32; P = 0.062); and subjects with NASH, 86% (SMR, 1.86; 95% CI, 1.19-2.76; P = 0.007).Patients with NASH are at increased risk of death compared with the general population. Liver disease is the third most common cause of death among patients with NAFLD.
Hospital doctors and nurses should sit with GPs on commissioning boards, say MPs
Authors: Z. Kmietowicz
Journal: BMJ (2011)

Hospitals doctors, nurses, a public health expert, a local councillor, and a social care representative should sit alongside a majority of GPs on the boards of local commissioning bodies, which should be named NHS commissioning authorities and not GP consortiums, MPs have said.

In a damning report on the government’s plans for the NHS in England, MPs from the cross party select committee on health said that efficient and empowered commissioning is vital if the NHS is to meet the “Nicholson challenge”—the challenge by David Nicholson, the NHS’s chief executive, to achieve £20bn (€22.7bn; $32.3bn) of efficiency savings in the next four years.

The current state of reorganisation of the NHS risks demoralising its workforce and dividing primary and secondary care further rather than bringing them together in the interests of patients, says the report.

The conservative MP Stephen Dorrell, the committee’s chairman and a former health secretary, said that the government’s current plans for reforming the NHS fail to “secure clinical engagement around commissioning” and to ensure good governance. The changes being called for were not …
Care of emergencies in the United Kingdom.
Authors: M Irving
Journal: BMJ (1981)

The United Kingdom can claim the credit for organising the first comprehensive accident service in the world. In 1888 Sir Robert Jones was appointed consultant surgeon to the Man? chester Ship Canal. This major project linking the Port of Liverpool with the city of Manchester employed 20 000 workers on its 35-mile stretch. It took many years to build and exacted a high toll in serious injury. In one five-year period there were 3000 accidents. In order to cope with these emergencies the canal was divided by Sir Robert into three independent sections each with a chain of first-aid stations and each with its own hospital. Each hospital was staffed with a resident doctor and nurses. The hospitals were linked by a railway running the length of the canal that was used to convey the injured to the hospitals. They were also linked by wireless telegraphy to Sir Robert's Hospital in Liverpool so that he could be summoned whenever he was needed.
Localization of Human TACC3 to Mitotic Spindles Is Mediated by Phosphorylation on Ser558 by Aurora A: A Novel Pharmacodynamic Method for Measuring Aurora A Activity
Authors: Patrick J. LeRoy, John J. Hunter, Kara M. Hoar, Krissy E. Burke, Vaishali Shinde, Jason Ruan, Douglas Bowman, Katherine Galvin, Jeffrey A. Ecsedy
Journal: Cancer Research (2007)

Abstract Aurora A is a serine/threonine protein kinase essential for normal mitotic progression. Aberrant increased expression of Aurora A, which occurs frequently in human cancers, results in abnormal mitoses leading to chromosome instability and possibly tumorigenesis. Consequently, Aurora A has received considerable attention as a potential target for anticancer therapeutic intervention. Aurora A coordinates several essential mitotic activities through phosphorylation of a variety of proteins, including TACC3, which modulates microtubule stabilization of the mitotic spindle. Recent studies identified a conserved serine in Xenopus (Ser626) and Drosophila (Ser863) TACC3 orthologues that is phosphorylated by Aurora A. We show that this conserved serine on human TACC3 (Ser558) is also phosphorylated by Aurora A. Moreover, phosphorylation of TACC3 by Aurora A in human cells is essential for its proper localization to centrosomes and proximal mitotic spindles. Inhibition of Aurora A with the selective small molecule inhibitor MLN8054 in cultured human tumor cells resulted in mislocalization of TACC3 away from mitotic spindles in a concentration-dependent manner. Furthermore, oral administration of MLN8054 to nude mice bearing HCT-116 human tumor xenografts caused a dose-dependent mislocalization of TACC3 away from spindle poles that correlated with tumor growth inhibition. As TACC3 localization to mitotic spindles depends on Aurora A–mediated phosphorylation, quantifying TACC3 mislocalization represents a novel pharmacodynamic approach for measuring Aurora A activity in cancer patients treated with inhibitors of Aurora A kinase. [Cancer Res 2007;67(11):5362–70]
St. George's Hospital. CASES OF DIFFUSE INFLAMMATION OF THE PERINAeUM IN PATIENTS WITH DISEASED KIDNEYS
Authors: T. Holmes
Journal: BMJ (1855)

THE occurrence of symptoms referred to the bladder, in cases where the seat of disease is really in the kidneys, has been familiar to the profession ever since the publication of Sir B. Brodie's lectures, and cases of this sort must have come under the notice of almost every practitioner.I am not aware, however, that it has been pointed out with
Infant Feeding in Finnish Children &amp;lt;7 yr of Age With Newly Diagnosed IDDM
Authors: Suvi M Virtanen, Leena Räsänen, Antti Aro, Jaana Lindström, Henna Sippola, Raise Lounamaa, Liisa Toivanen, Jaakko Tuomilehto, Hans K Åkerblom
Journal: Diabetes Care (1991)

We studied associations between the type of feeding in infancy and the incidence of insulin-dependent diabetes mellitus (IDDM).We studied 103 newly diagnosed diabetic children less than 7 yr of age and 103 age- and sex-matched population-based control children in a countrywide study.The risk of IDDM was decreased (P less than 0.05) among children breast-fed for at least 7 mo (odds ratio [OR] 0.45, 95% confidence interval [CI] 0.24-0.85) or exclusively breast-fed for at least 3 (OR 0.33, 95% CI 0.13-0.84) or 4 (OR 0.43, 95% CI 0.22-0.84) mo. Also, children who were greater than or equal to 4 mo old at the time of introduction of supplementary milk feeding had a lower risk of diabetes (OR 0.48, 95% CI 0.26-0.91).The protective effects of a long duration of breast-feeding and a late introduction of dairy products on the risk of IDDM remained significant after adjusting for the mother's education.
Free fatty acids and sterols in human eccrine sweat
Authors: T. TAKEMURA, P.W. WERTZ, K. SATO
Journal: British Journal of Dermatology (1989)

Journal Article Free fatty acids and sterols in human eccrine sweat Get access T. TAKEMURA, T. TAKEMURA Marshall Dermatology Research Laboratories, Department of Dermatology, University of lowa College of Medicine, Iowa City, Iowa 52242, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar P.W. WERTZ, P.W. WERTZ Marshall Dermatology Research Laboratories, Department of Dermatology, University of lowa College of Medicine, Iowa City, Iowa 52242, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar K. SATO K. SATO Marshall Dermatology Research Laboratories, Department of Dermatology, University of lowa College of Medicine, Iowa City, Iowa 52242, U.S.A. K.Sato. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 120, Issue 1, 1 January 1989, Pages 43–47, https://doi.org/10.1111/j.1365-2133.1989.tb07764.x Published: 01 January 1989
Cut winter fuel payments for wealthy to provide more care for poor elderly, says think tank
Authors: N. Hawkes
Journal: BMJ (2014)

Winter fuel payments should be limited to poor pensioners, with the £1.5bn (€1.9bn; $2.6bn) a year saved being used to fund care services for greater numbers of elderly people than currently receive them, says the Institute for Public Policy Research in a new publication.1 It also proposes a new programme to encourage people with long term health conditions or disabilities back into work, with small employers being incentivised to offer jobs by being reimbursed for any sick pay costs they might …
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
Authors: Katrin Kierdorf, Daniel Erny, Tobias Goldmann, Victor Sander, Christian Schulz, Elisa Gomez Perdiguero, Peter Wieghofer, Annette Heinrich, Pia Riemke, Christoph Hölscher, Dominik N Müller, Bruno Luckow, Thomas Brocker, Katharina Debowski, Günter Fritz, Ghislain Opdenakker, Andreas Diefenbach, Knut Biber, Mathias Heikenwalder, Frederic Geissmann, Frank Rosenbauer, Marco Prinz
Journal: Nature Neuroscience (2013)
Tolerance-related V beta clonal deletions in normal CD4-8-, TCR-alpha/beta + and abnormal lpr and gld cell populations.
Authors: P A Singer, R S Balderas, R J McEvilly, M Bobardt, A N Theofilopoulos
Journal: The Journal of Experimental Medicine (1989)

We have analyzed tolerance-related clonal deletion of Mls-and I-E-reactive thymocytes at the RNA level using a multi-V beta probe RNAse protection assay, and used this phenomenon to identify the maturation stage of the abnormally expanded CD4-8-, TCR-alpha/beta + subset in lpr and gld homozygous mice, and of the phenotypically similar minor thymocyte subset found in normal mice. Essentially complete V beta clonal deletions were detected in lpr and gld cells of all appropriate background strains. Substantial, but not complete, V beta clonal deletions were also detected in the CD4-8- TCR-alpha/beta + subset of normal mice. Since expression of CD4/CD8 is required for V beta clonal deletions to occur, we conclude that lpr and gld cells, and at least a portion of CD4-8- TCR-alpha/beta + thymocytes in normal mice, are derived by secondary loss of CD4/CD8 accessory molecules from more mature CD4+8+ precursors. One possible interpretation of these findings is that such CD4/CD8 loss may affect a class of self-reactive thymocytes that have escaped direct clonal deletion. Exportation and expansion of such cells in the periphery may be an important contributory factor in the induction of systemic autoimmunity.
BALSAM OF PERU IN MASTOID SURGERY
Authors: John Leshure
Journal: JAMA (1926)

The use of Peruvian balsam is certainly not new, but judging from inquiries that I have made, this valuable drug has not the general acceptance that its merit warrants. At the completion of the mastoid operation and after the middle ear has been flushed through the aditus, the wound is tightly packed with a gauze pad saturated with a mixture of equal parts of balsam and alcohol. This is removed one or two minutes later and serves the double purpose of sterilizing the wound and checking oozing. The wound is then lightly packed with one-half inch strip gauze moistened in 1:5,000 solution of mercuric chloride and the balsam-alcohol mixture. Over this, plain gauze pads moistened in mercuric chloride solution are placed with rubber tissue over all and bandaged as usual. The first dressing is made forty-eight hours later, and this interval is observed for the first three dressings, at the
Insomnia Increases Stroke Risk
Authors: Anita Slomski
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOME ADDITIONAL OBSERVATIONS ON THE EFFECTS OF INJURY TO PERIPHERAL NERVES.
Authors: D. S. FAIRCHILD
Journal: JAMA (1901)

Two years ago I read a paper before the Academy, on "Injuries to Peripheral Nerves," in which a case was related illustrating the effects of a comparatively slight injury to the nerves of the thumb, resulting in very distressing symptoms covering a period of more than two years. The extremely painful symptoms were due to a pressure lesion including the branches of the median nerve supplying the thumb. The amount and density of the connective tissue attending the healing of the wound was remarkable. The healing of the original injury was scarcely accomplished before painful twitching of the thumb occurred. It was at once recognized that the nerve branches were caught in the scar, and it was apparent that relief could be obtained only through surgical means. Twice the scar was dissected out and the nerve freed. Later the external cutaneous and the collateral branches of the median supplying the
Cyclosporin and discoid lupus erythematosus
Authors: J.A. Yell, S.M. Burge
Journal: British Journal of Dermatology (1994)

Journal Article Cyclosporin and discoid lupus erythematosus Get access J.A. Yell, J.A. Yell Department of Dermatology. Churchill Hospital, Headington, Oxford OX3 7LJ, U.K. Search for other works by this author on: Oxford Academic Google Scholar S.M. Burge S.M. Burge Department of Dermatology. Churchill Hospital, Headington, Oxford OX3 7LJ, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 131, Issue 1, 1 July 1994, Pages 132–133, https://doi.org/10.1111/j.1365-2133.1994.tb08471.x Published: 01 July 1994
Intravascular haemolysis in the recreational runner.
Authors: R W Deitrick
Journal: British Journal of Sports Medicine (1991)

Intravascular haemolysis has been found to result from prolonged endurance competition, rigorous military training and participation in impact sports. Haematological research involving the recreational runner is sparse. Recreational runners frequently vary their training to avoid monotony and improve endurance capacity. This study investigated the haematological effects of a typical day of increased distance training in 15 male recreational runners (62.4(3.1) ml kg-1 min-1 treadmill VO2max; 44.6(8.4) km per week training (means(s.d.)). Venous blood samples were collected before, immediately after, 1 day, 4 days, and 10 days after a 13-km training run (about twice the subjects' typical running distance) and analysed for changes in bilirubin, serum potassium, haematocrit, haemoglobin, red blood cell count, haptoglobin, poikilocytosis and reticulocytosis. Urine samples were collected at the same times as the blood samples and analysed for urobilinogen. Significant (P less than 0.05) 1-day and 4-day decreases in mean haemoglobin, red blood cell count, and haptoglobin values, compared to before training venous blood values and significant (P less than 0.05) post-training increases in bilirubin, serum potassium, urobilinogen and poikilocytosis provided evidence for increased intravascular haemolysis. After 10 days the values for haematocrit, bilirubin, serum potassium, red blood cell count, urobilinogen and poikilocytosis were not significantly (P less than 0.05) different from pre-training values while haemoglobin remained significantly (P less than 0.05) lower, exhibiting a constant but not significant increase over the period from 1 to 10 days. The results indicate that mild intravascular 'footstrike' haemolysis can occur in the recreational runner when typical training distance is increased. This condition appears to be transient and benign.
Atrial natriuretic peptide in portal vein–ligated rats: Alterations in cardiac production, plasma level and glomerular receptor density and affinity
Authors: Gavin M. Jonas, Timothy R. Morgan, Kengathevy Morgan, Inthirany Thillainadarajah, Cynthia Hornacek
Journal: Hepatology (1992)

The atrial natriuretic peptide hormonal system is altered to a variable degree in patients with cirrhosis. Portal pressure and portal-systemic shunting are also varied in cirrhosis. We used a portal vein–ligated rat model with predictable portal hypertension to study the effects of portal hypertension alone on the atrial natriuretic peptide hormonal system. Sham-operated rats were used as controls. Mean portal pressure was significantly increased in portal vein–ligated rats (portal vein–ligated rats, 21.7 ± 0.74 cm H2O; sham-operated rats, 13.7 ± 0.47 cm H2O; p < 0.0001). Plasma atrial natriuretic peptide decreased 50% in the portal vein–ligated rats (p < 0.0001). Atrial natriuretic peptide messenger RNA level was decreased by 40% to 60% in the left and right atria and in the ventricles of portal vein–ligated rats (p < 0.05 for each chamber). Only one class of glomerular binding site was identified by competitive binding studies. The atrial natriuretic peptide glomerular receptor density increased in the portal vein–ligated rats (portal vein–ligated rats, 1,660 ± 393; sham-operated 725 ± 147 fmol/mg protein, p < 0.02), whereas affinity decreased (portal vein–ligated, 1.69 ± 0.49; sham-operated, 0.55 ± 0.12 nmol/L, p < 0.02). No difference was seen in the amount of cyclic GMP generated by atrial natriuretic peptide stimulation in isolated glomeruli from portal vein–ligated and sham-operated rats. Thus, in the rat model of portal hypertension without liver disease, decreased plasma atrial natriuretic peptide level is associated with decreased cardiac atrial natriuretic peptide messenger RNA and increased density (but decreased affinity) of glomerular atrial natriuretic peptide binding sites. Portal hypertension alone may account for the increased density of glomerular atrial natriuretic peptide binding sites reported in cirrhosis, but it does not account for the changes in cardiac atrial natriuretic peptide and plasma atrial natriuretic peptide reported by most investigators. (Hepatology 1992;15:696–701).
Implications of Psychoactive Drug Therapy
Authors: Elmer A. Gardner
Journal: New England Journal of Medicine (1974)

Elsewhere in this issue of the Journal, Balter, Levine and Manheimer report on the patterns of anti-anxiety/sedative drug use in Western European society to provide a better perspective about the consumption of these drugs in this country. This is one in a series of reports emanating from a collaborative effort by the Social Research Group of the George Washington University, the Institute for Research in Social Behavior, Berkeley, California, and the Psychopharmacology Research Branch of the National Institute of Mental Health. These surveys provide vitally needed information at a time when prescription practices in general, and psychoactive drug prescribing . . .
Abstract 4643: Epstein-Barr virus infection (EBV) and expression of B-cell oncogenic markers in HIV+ diffuse large B-cell lymphoma (DLBCL)
Authors: Chun R. Chao, Donald Abrams, Michael J. Silverberg, Reina Haque, Hongbin D. Zha, Otoniel Martinez-Maza, Michelle McGuire, Margaret Chi, Brandon Castor, Lanfang Xu, Wendy Leyden, Laurel Habel, Jonathan Said
Journal: Cancer Research (2011)

Abstract Background: Lymphomagenicity of EBV in the setting of HIV infection has been widely accepted. However, the underlying carcinogenic mechanism of EBV is largely unknown and warrants further study. We sought to investigate the hypothesis that EBV infection is associated with expression of specific B-cell oncogenic markers in HIV+ DLBCL. Methods: HIV+ DLBCL cases diagnosed between 1996-2007 within the Kaiser Permanente California Health Plan were identified. Archived tumor specimens were retrieved and H&amp;E slides were reviewed to identify representative tumor blocks for tissue microarray (TMA) construction. Immunohistochemistry staining was performed on TMA cores to analyze the expression of selected B-cell oncogenic markers in the following categories: (1) mutagenic molecule (that induce mutation/translocation), (2) cell cycle promoter, (3) B-cell activator and (4) anti-apoptotic protein. Percent of DLBCL cells with visible marker staining was scored on a scale from 0-4 (0-9%, 10-24%, 25-49%, 50-74% and ≥75%). EBV infection was determined by in situ hybridization of EBV encoded RNA and was considered positive if ≥10% of the DLBCL cells had detectable EBV. Correlations between EBV and marker expression were examined using Spearman's correlation coefficient. Results: We identified 194 HIV+ DLBCL cases. Of these, 117 lacked sufficient tissue; another 7 had undetermined EBV status; and 70 were included in the study. Marker expressions are shown in the table: Conclusion: There was a suggestion that Cyclin E and PKC-β2 were more commonly expressed in EBV+ DLBCL, and that FOXP1, BCL2, and Survivin were more commonly expressed in EBV- DLBCL. However, none of these associations reached statistical significance. These findings provide limited support that the underlying carcinogenic mechanism of EBV involves the mediation of the expression of oncogenic markers examined here. However, our study power was limited, thus requiring confirmation in larger studies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4643. doi:10.1158/1538-7445.AM2011-4643