tbuckley/cabot-search huggingface dataset:
The Evaluation of Stack Metal Emissions from Hazardous Waste Incinerators: Assessing Human Exposure through Noninhalation Pathways
Authors: Richard M. Sedman, James M. Polisini, John R. Esparza
Journal: Environmental Health Perspectives (1994)

Potential public health effects associated with exposure to metal emissions from hazardous waste incinerators through noninhalation pathways were evaluated. Instead of relying on modeling the movement of toxicants through various environmental media, an approach based on estimating changes from baseline levels of exposure was employed. Changes in soil and water As, Cd, Hg, Pb, Cr, and Be concentrations that result from incinerator emissions were first determined. Estimates of changes in human exposure due to direct contact with shallow soil or the ingestion of surface water were then ascertained. Projected changes in dietary intakes of metals due to incinerator emissions were estimated based on changes from baseline dietary intakes that are monitored in U.S. Food and Drug Administration total diet studies. Changes from baseline intake were deemed to be proportional to the projected changes in soil or surface water metal concentrations. Human exposure to metals emitted from nine hazardous waste incinerators were then evaluated. Metal emissions from certain facilities resulted in tangible human exposure through noninhalation pathways. However, the analysis indicated that the deposition of metals from ambient air would result in substantially greater human exposure through noninhalation pathways than the emissions from most of the facilities.
Prevention of Implantable-Defibrillator Shocks by Treatment with Sotalol
Authors: Antonio Pacifico, Stefan H. Hohnloser, John H. Williams, Ben Tao, Sanjeev Saksena, Philip D. Henry, Eric N. Prystowsky
Journal: New England Journal of Medicine (1999)

Patients with implantable cardioverter–defibrillators often receive adjunctive antiarrhythmic therapy to prevent frequent shocks. We tested the efficacy and safety of sotalol, a beta-blocker with class III antiarrhythmic effects, for this purpose.
Carbon Monoxide From Domestic Coffee Roasting: A Case Report
Authors: Joel B. Raffel, Joanne Thompson
Journal: Annals of Internal Medicine (2013)

LettersDecember 3, 2013Carbon Monoxide From Domestic Coffee Roasting: A Case ReportJoel B. Raffel, BMBCh and Joanne Thompson, BA, MB BChirJoel B. Raffel, BMBChFrom Imperial College London, London, United Kingdom.Search for more papers by this author and Joanne Thompson, BA, MB BChirFrom Imperial College London, London, United Kingdom.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-11-201312030-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: During roasting, coffee beans generate substantial carbon monoxide, much of which is released during grinding (1). Fatal and near-fatal acute carbon monoxide exposures have occurred in industrial coffee-processing plants (2, 3).Purpose: To describe the first reported cases to our knowledge of acute carbon monoxide poisoning from domestic coffee roasting.Case Report: In March 2013, 2 women aged 47 and 48 years of Eritrean origin arrived at a London hospital by ambulance. They had developed vomiting, abdominal cramps, headache, and vertigo while preparing coffee together. When symptoms began, 1 woman opened a window hoping for symptomatic relief. The other ...References1. Clarke RJ. Roasting and grinding.. In: Clarke RJ, Macrae R, eds. Coffee Technology. vol. 2. New York Elsevier Science 1987 73-89. Google Scholar2. Newton J. Carbon monoxide exposure from coffee roasting. Appl Occup Environ Hyg. 2002;17:600-2. [PMID: 12216587] CrossrefMedlineGoogle Scholar3. Nishimura F, Abe S, and Fukunaga T. Carbon monoxide poisoning from industrial coffee extraction [Letter]. JAMA. 2003;290:334. [PMID: 12865373] MedlineGoogle Scholar4. Keil C, Kassa H, Brown A, Kumie A, and Tefera W. Inhalation exposures to particulate matter and carbon monoxide during Ethiopian coffee ceremonies in Addis Ababa: a pilot study. J Environ Public Health. 2010;2010:213960. [PMID: 20886061] CrossrefMedlineGoogle Scholar5. Hampson NB, Piantadosi CA, Thom SR, and Weaver LK. Practice recommendations in the diagnosis, management, and prevention of carbon monoxide poisoning. Am J Respir Crit Care Med. 2012;186:1095-101. [PMID: 23087025] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Imperial College London, London, United Kingdom.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics December 3, 2013Volume 159, Issue 11Page: 795-796KeywordsAir pollutionAmbulancesBloodBlood pressureCarbon monoxideCoffeeComaConsciousnessGas analysisHeadachesHealth promotionHeart rateInhalationOxygenPrevention, policy, and public healthVertigoVomiting ePublished: 3 December 2013 Issue Published: December 3, 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Early Macrophage Recruitment and Alternative Activation Are Critical for the Later Development of Hypoxia-Induced Pulmonary Hypertension
Authors: Eleni Vergadi, Mun Seog Chang, Changjin Lee, Olin D. Liang, Xianlan Liu, Angeles Fernandez-Gonzalez, S. Alex Mitsialis, Stella Kourembanas
Journal: Circulation (2011)

Background— Lung inflammation precedes the development of hypoxia-induced pulmonary hypertension (HPH); however, its role in the pathogenesis of HPH is poorly understood. We sought to characterize the hypoxic inflammatory response and to elucidate its role in the development of HPH. We also aimed to investigate the mechanisms by which heme oxygenase-1, an anti-inflammatory enzyme, is protective in HPH. Methods and Results— We generated bitransgenic mice that overexpress human heme oxygenase-1 under doxycycline control in an inducible, lung-specific manner. Hypoxic exposure of mice in the absence of doxycycline resulted in early transient accumulation of monocytes/macrophages in the bronchoalveolar lavage. Alveolar macrophages acquired an alternatively activated phenotype (M2) in response to hypoxia, characterized by the expression of found in inflammatory zone-1, arginase-1, and chitinase-3-like-3. A brief 2-day pulse of doxycycline delayed, but did not prevent, the peak of hypoxic inflammation, and could not protect against HPH. In contrast, a 7-day doxycycline treatment sustained high heme oxygenase-1 levels during the entire period of hypoxic inflammation, inhibited macrophage accumulation and activation, induced macrophage interleukin-10 expression, and prevented the development of HPH. Supernatants from hypoxic M2 macrophages promoted the proliferation of pulmonary artery smooth muscle cells, whereas treatment with carbon monoxide, a heme oxygenase-1 enzymatic product, abrogated this effect. Conclusions— Early recruitment and alternative activation of macrophages in hypoxic lungs are critical for the later development of HPH. Heme oxygenase-1 may confer protection from HPH by effectively modifying the macrophage activation state in hypoxia.
<i>Aspergillus fumigatus</i> specific IgE and IgG antibodies for diagnosis of <i>Aspergillus</i>‐related lung diseases
Authors: I. Wallenbeck, S. Dreborg, O. Zetterström, R. Einarsson
Journal: Allergy (1991)

IgE and IgG antibodies against Aspergillus fumigatus were detected by crossed radio immunoelectrophoresis (CRIE) on the sera of seven patients with aspergilloma, six patients with allergic broncho-pulmonary aspergillosis (ABPA) and 25 patients with extrinsic asthma with Aspergillus allergy. IgE-CRIE analysis indicated the presence of A. fumigatus-specific IgE in sera of patients with ABPA and Aspergillus asthma but not of aspergilloma patients. IgG-CRIE showed that both aspergilloma and ABPA patient sera contained high levels of circulating specific IgG antibodies in contrast to sera of Aspergillus asthma patients, which did not show detectable amounts of Aspergillus-specific IgG antibodies. Specific IgE binding could be demonstrated for the major allergens Ag-10 and AG-40 in all ABPA patients, in 80% of Aspergillus asthma patients but not in sera from aspergilloma patients. Specific IgG antibodies directed towards the major allergens could be detected in most of the aspergilloma patients, between 30-70% of the ABPA patients but not in sera from patients with Aspergillus asthma.
Prevention of Rh-Haemolytic Disease: A Third Report
Authors: J. C. Woodrow, C. A. Clarke, W. T. A. Donohoe, R. Finn, R. B. McConnell, P. M. Sheppard, D. Lehane, S. H. Russell, W. Kulke, C. M. Durkin
Journal: BMJ (1965)

In two papers (Finn et d., 1961; Clarke it al., 1963) we described experiments which were successful in preventing Rh immunization in Rh-negative male volunteers. The basis of the procedure was to remove rapidly from the circulation previously injected chromium-tagged Rh-positive red cells by giving hightitre incomplete anti-D either as an infusion of plasma or as gamma3-globulin. In our second paper we stated that the next steps should be to find out whether foetal red cells could be cleared equally well as adult and whether female volunteers could be protected in the same way as men. The results of experiments to test these points form the first part (I) of the present paper. The second part (II) concerns two factors of great importance in the application of the technique to preventing Rh immunization due to pregnancy. These are the frequency with which transplacental haemorrhage from foetus to mother occurs during pregnancy as distinct from at delivery, and the relation of the production of immune antibodies to the size of transplacental haemorrhage assessed after delivery. In the third part of the paper (III) we discuss some of the details of the clinical trial, recently started in Liverpool, of anti-D gamma2-globulin injection given to Rh-negative Women after delivery.
MMP and TIMP Expression Pattern in Pleural Effusions of Different Origins
Authors: OLIVER EICKELBERG, CARSTEN O. SOMMERFELD, CHRISTOPH WYSER, MICHAEL TAMM, FRANK REICHENBERGER, PHILIP G. BARDIN, MARKUS SOLÈR, MICHAEL ROTH, ANDRÉ P. PERRUCHOUD
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

The matrix metalloproteinases (MMP) are proteolytic enzymes that are essentially involved in the turnover of the extracellular matrix (ECM). Their activity is counterbalanced by specific antagonists, the tissue inhibitors of metalloproteinases (TIMP). In this study, we sought to analyze the expression of MMP and TIMP isoforms in pleural effusions from 88 patients. We compared MMP and TIMP isoform expression in transudates (n = 21) and exudates (n = 67), the latter divided into exudates of paraneoplastic (n = 46) or parainfectious (n = 21) origin. Zymographic and Western blot analyses revealed constant expression of interstitial collagenase (MMP-1), gelatinase-A (MMP-2), and TIMP-1 in all 88 samples. In contrast, analyses of gelatinase-B (MMP-9) demonstrated a specific expression pattern, with high expression in exudates and lack of expression in transudates. Neutrophil collagenase (MMP-8) was detected in trace amounts, and correlated with the number of neutrophils in the effusion. Low levels of TIMP-2 were detected only in exudates and not in transudates. Quantitative analysis of the expression ratio of gelatinase-B to gelatinase-A revealed statistically significant differences between effusions of different origin. The ratio was highest in exudates of paraneoplastic origin and lowest in transudates. Our data thus suggest that interstitial collagenase, gelatinase-A, and TIMP-1 play a role in homeostasis of the pleural space in vivo as constitutively expressed proteins, whereas gelatinase-B and TIMP-2 expression are induced in specific disease states. These observations contribute to the understanding of the pathophysiology of pleural effusions, and may help to characterize and possibly distinguish effusions of different origin.
HTLV-1 bZIP Factor HBZ Promotes Cell Proliferation and Genetic Instability by Activating OncomiRs
Authors: Céline Vernin, Morgan Thenoz, Christiane Pinatel, Antoine Gessain, Olivier Gout, Marie-Hélène Delfau-Larue, Nicolas Nazaret, Catherine Legras-Lachuer, Eric Wattel, Franck Mortreux
Journal: Cancer Research (2014)

Viruses disrupt the host cell microRNA (miRNA) network to facilitate their replication. Human T-cell leukemia virus type I (HTLV-1) replication relies on the clonal expansion of its host CD4(+) and CD8(+) T cells, yet this virus causes adult T-cell leukemia/lymphoma (ATLL) that typically has a CD4(+) phenotype. The viral oncoprotein Tax, which is rarely expressed in ATLL cells, has long been recognized for its involvement in tumor initiation by promoting cell proliferation, genetic instability, and miRNA dysregulation. Meanwhile, HBZ is expressed in both untransformed infected cells and ATLL cells and is involved in sustaining cell proliferation and silencing virus expression. Here, we show that an HBZ-miRNA axis promotes cell proliferation and genetic instability, as indicated by comet assays that showed increased numbers of DNA-strand breaks. Expression profiling of miRNA revealed that infected CD4(+) cells, but not CD8(+) T cells, overexpressed oncogenic miRNAs, including miR17 and miR21. HBZ activated these miRNAs via a posttranscriptional mechanism. These effects were alleviated by knocking down miR21 or miR17 and by ectopic expression of OBFC2A, a DNA-damage factor that is downregulated by miR17 and miR21 in HTLV-1-infected CD4(+) T cells. These findings extend the oncogenic potential of HBZ and suggest that viral expression might be involved in the remarkable genetic instability of ATLL cells.
Invagination of the muscularis propria in a polyp stalk: a rare cause of post-polypectomy perforation of the colon
Authors: S. Ahlawat, F. Al-Kawas
Journal: Endoscopy (2007)

A 23-year-old white woman underwent colonoscopy for the investigation of hematochezia. She was found to have a 5-cm pedunculated polyp in the sigmoid colon (Figure [1]). A standard injection-assisted polypectomy was performed. A 10-mm defect was noted immediately afterward at the polypectomy site (Figure [2 a]), and this was closed using six endoscopic clips (Figure [2 b]). The area was tattooed with India ink.
von Willebrand factor interaction with the glycoprotein IIb/IIa complex. Its role in platelet function as demonstrated in patients with congenital afibrinogenemia.
Authors: L De Marco, A Girolami, T S Zimmerman, Z M Ruggeri
Journal: Journal of Clinical Investigation (1986)

We have studied three afibrinogenemic patients, who had only trace amounts of plasma and platelet fibrinogen as measured by radioimmunoassay, and demonstrate here that the residual aggregation observed in their platelet-rich plasma is dependent upon von Willebrand factor (vWF) binding to the platelet membrane glycoprotein (GP)IIb/IIIa complex. The abnormality of aggregation was more pronounced when ADP, rather than thrombin, collagen, or the combination of ADP plus adrenaline was used to stimulate platelets. With all stimuli, nevertheless, the platelet response was completely inhibited by a monoclonal antibody (LJP5) that is known to block vWF, but not fibrinogen binding to GPIIb/IIIa. Addition of purified vWF to the afibrinogenemic plasma resulted in marked increase in the rate and extent of aggregation, particularly when platelets were stimulated with ADP. This response was also completely blocked by LJP5. Addition of fibrinogen, however, restored normal aggregation even in the presence of LJP5, a finding consistent with the knowledge that antibody LJP5 has no effect on platelet aggregation mediated by fibrinogen binding to GPIIb/IIIa. Two patients gave their informed consent to receiving infusion of 1-desamino-8-D-arginine vasopressin (DDAVP), a vasopressin analogue known to raise the vWF levels in plasma by two- to fourfold. The bleeding time, measured before and 45 min after infusion, shortened from greater than 24 min to 12 min and 50 s in one patient and from 16 min to 9 min and 30 s in the other. Concurrently, the rate and extent of ADP-induced platelet aggregation improved after DDAVP infusion. The pattern, however, reversed to baseline levels within 4 h. The concentration of plasma vWF increased after DDAVP infusion, but that of fibrinogen remained at trace levels. We conclude that vWF interaction with GPIIb/IIIa mediates platelet-platelet interaction and may play a role in primary hemostasis.
In noncardiac surgery, perioperative aspirin did not reduce death or MI at 30 d but increased major bleeding
Authors: Ellis Lader
Journal: Annals of Internal Medicine (2014)

ACP Journal Club19 August 2014In noncardiac surgery, perioperative aspirin did not reduce death or MI at 30 d but increased major bleedingEllis Lader, MDEllis Lader, MDMid Valley Cardiology, New York University School of Medicine, Kingston, New York, USA (E.L.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-161-4-201408190-02005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationDevereaux PJ, Mrkobrada M, Sessler DI, et al; POISE-2 Investigators. Aspirin in patients undergoing noncardiac surgery. N Engl J Med. 2014;370:1494-503. https://pubmed.ncbi.nlm.nih.gov/24679062Clinical Impact RatingsGIM/FP/GP: Hospitalists: Cardiology: Hematology: References1 Chopra V, Wesorick DH, Sussman JB, et al. Effect of perioperative statins on death, myocardial infarction, atrial fibrillation, and length of stay: a systematic review and meta-analysis. Arch Surg. 2012;147:181-9. [PMID: 22351917] Google Scholar2 Joint Statement: Issued by the American College of Cardiology, American Heart Association, and the European Society of Cardiology. August 5, 2013. www.cardiosource.org/News-Media/Publications/Cardiology-Magazine/2013/08/Joint-Statement.aspx (accessed 16 Jun 2014). Google Scholar3 Baigent C, Blackwell L, Collins R, et al; Antithrombotic Trialists' (ATT) Collaboration. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet. 2009;373:1849-60. [PMID: 19482214] Google Scholar Author, Article, and Disclosure InformationAuthors: Ellis Lader, MDAffiliations: Mid Valley Cardiology, New York University School of Medicine, Kingston, New York, USA (E.L.)This article was published at Annals.org on 5 August 2014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Impact of Nonsteroidal Anti-inflammatory Drugs on Older Adult Trauma Patients With Hip Fractures 19 August 2014Volume 161, Issue 4Page: JC5KeywordsAspirinCardiac surgeryDrugsHemorrhageMyocardial infarctionPlateletsStable coronary artery diseaseStent implantationSurgeryVascular surgery ePublished: 19 August 2014 Issue Published: 19 August 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Diuretic requirements after therapeutic paracentesis in non-azotemic patients with cirrhosis. A randomized double-blind trials of spironolactone versus placebo
Authors: Glòria Fernández-Esparrach, Mònica Guevarra, Pau Sort, Albert Pardo, Wladimiro Jiménez, Pere Ginès, Ramon Planas, Didier Lebrec, André Geuvel, André Elewaut, Michael Adler, Vicente Arroyo
Journal: Journal of Hepatology (1997)
Insulin Shock Treatment in Children with Psychotic Disturbances
Authors: Anna-Lisa Annell
Journal: Psychotherapy and Psychosomatics (1955)

Research Articles| January 20 2010 Insulin Shock Treatment in Children with Psychotic Disturbances Subject Area: Psychiatry and Psychology Anna-Lisa Annell Anna-Lisa Annell From the Department of Child Psychiatry, University Hospital, Uppsala, Sweden Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1955) 3 (3): 193–205. https://doi.org/10.1159/000278484 Article history Published Online: January 20 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Anna-Lisa Annell; Insulin Shock Treatment in Children with Psychotic Disturbances. Acta Psychotherapeutica et Psychosomatica 1 March 1955; 3 (3): 193–205. https://doi.org/10.1159/000278484 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1955Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Addison and Bright at the St Alban's Club
Authors: D. Hay
Journal: Journal of the Royal Society of Medicine (2004)

Dr Pearce's interesting survey of Thomas Addison's life (June 2004 JRSM1) draws attention to the subject's melancholic nature. I can add a footnote on this subject.

I have recently completed the history of the St Alban's Medical Club which, with its brother club the Sydenham, has continuous records starting in the last two decades of the eighteenth century. Thomas Addison was elected to the St Alban's Club in 1830 but had resigned less than three years later. His letter of resignation survives in the club's archives at the Wellcome Institute for the History of Medicine. At the time the leading figures in the club were Charles Locock (who later became Queen Victoria's accoucheur) and his boyhood friend Thomas Waterfield. Several of the surgeons and the surgeon-apothecaries in the Club had served with Wellington in the Peninsular War and at Waterloo. They were a group of extroverts whose bets and wagers were settled in claret and champagne. Clearly Addison, not by nature clubbable, felt that this was not his scene. His friend and colleague Richard Bright, elected a little later and after Addison's resignation, was happier on such hearty occasions, but the treasurer's book often records that 'Dr Bright came after dinner'. Neither of these famous men, melancholic or not, played a leading part in the club's jolly evening meetings.