Congenital Heart Block and Connective Tissue Disease
Authors: EVELYN V. HESS
Journal: Annals of Internal Medicine (1979)

Editorial Notes1 October 1979Congenital Heart Block and Connective Tissue DiseaseEVELYN V. HESS, M.D., GEORGE SPENCER-GREEN, M.D.EVELYN V. HESS, M.D.Search for more papers by this author, GEORGE SPENCER-GREEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-4-645 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSystemic Lupus Erythematosus (SLE) is an immunologically mediated disease occurring most frequently in a female population of child-bearing age with target organs potentially in any body system. Several recent publications have brought to attention the fact that the fetus of a mother with systemic lupus erythematosus is also at risk to develop complications of its mother's disease. Most offspring of the mothers are normal, but transient as well as permanent residua have been observed, including the well-recognized phenomenon of discoid rash, leukopenia, thrombocytopenia, and Coombs'-positive hemolytic anemia with LE cells and antinuclear antibodies. These transient phenomena occur at or soon...References1. ESSCHERSCOTT EJ. Congenital heart block and maternal systemic lupus erythematosus. Brit Med J. 1979;1:1235-8. CrossrefMedlineGoogle Scholar2. HARDYSOLOMONBANWELLBEACHWRIGHTHOWARD JSGRVF. Congenital complete heart block in the newborn associated with maternal systemic lupus erythematosus and other connective tissue disorders. Arch Dis Child. 1979;54:7-13. CrossrefMedlineGoogle Scholar3. MICHAELSSONENGLE MM. Congenital complete heart block: an international study of the natural history. In: ENGLE MA, ed. Pediatric Cardiology. Vol. 4, No. 3, in the series Cardiovascular Clinics. BREST AN, ed. Philadelphia: F.A. Davis Co.; 1972:85-101. Google Scholar4. FRAGAMINTZDROZASDROZCO AGJJ. Sterility and fertility rates, fetal wastage and maternal morbidity in systemic lupus erythematosus. J Rheumatol. 1974;1:293-8. Google Scholar5. ESTESLARSON DD. Systemic lupus erythematosus and pregnancy. Clin Obst Gynecol. 1965;8:307-21. CrossrefGoogle Scholar6. BRESNIHANGRIGOROLIVERLEWKONIAHUGHES BRMRG. Immunological mechanism for spontaneous abortion in systemic lupus erythematosus. Lancet. 1977;2:1205-7. CrossrefMedlineGoogle Scholar7. CHAMEIDESTRUEXVETTERRASHKINDGALIOTONOONAN LRVWFJ. Maternal systemic lupus erythematosus and congenital complete heart block. N Engl J Med. 1977;297:1204-7 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EVELYN V. HESS, M.D.; GEORGE SPENCER-GREEN, M.D.Affiliations: Immunology Division Department of Medicine University of Cincinnati Medical Center Cincinnati, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFetal congenital heart block and maternal systemic lupus erythematosus: Can plasma exchanges play a useful role?Systemic Lupus ErythematosusCardiovascular manifestations of systemic lupus erythematosus: Current perspectiveNeonatal Lupus Erythematosus: A ReviewOrthopedic surgeryNeonatal lupus erythematosus with heart block: family study of a patient with anti–-ss-a and ss-b antibodiesDiscoid Lupus ErythematosusCardiac Manifestations of SLESystemic Lupus Erythematosus in PregnancyLEON G. FINE, M.B., Ch.B., EUGENE V. BARNETT, M.D., GABRIEL M. DANOVITCH, M.B., B.S., ALLEN R. NISSENSON, M.D., MATTHEW E. CONOLLY, M.D., STEPHEN M. LIEB, M.D., CYNTHIA T. BARRETT, M.D.Lupus erythematosus 1 October 1979Volume 91, Issue 4Page: 645-646KeywordsConnective tissue diseasesFellowshipsFetusesHeart diseasesHemolytic anemiaLupus erythematosusNeutrophilsRashesStem cellsSystemic lupus erythematosus ePublished: 1 December 2008 Issue Published: 1 October 1979 PDF downloadLoading ...