tbuckley/cabot-search huggingface dataset:
Significance of Late Diastolic Potential Preceding Purkinje Potential in Verapamil-Sensitive Idiopathic Left Ventricular Tachycardia
Authors: Takeshi Tsuchiya, Ken Okumura, Toshihiro Honda, Takashi Honda, Atsushi Iwasa, Hirofumi Yasue, Toshifumi Tabuchi
Journal: Circulation (1999)

Verapamil-sensitive idiopathic left ventricular tachycardia (VT) is due to reentry with an excitable gap. A late diastolic potential (LDP) is recorded during endocardial mapping of this VT, but its relation to the reentry circuit and significance in radiofrequency (RF) ablation remain to be elucidated.Sixteen consecutive patients with this specific VT were studied (12 men and 4 women; mean age, 32 years). In all patients, sustained VT was induced and during left ventricular endocardial mapping, LDP preceding Purkinje potential (PP) was recorded at the basal (11 patients), middle (3 patients), or apical septum (2 patients). The area with LDP recording was confined to a small region (0.5 to 1.0 cm2) in each patient and was included in the area where PP was recorded (2 to 3 cm2). The relative activation times of LDP, PP, and local ventricular potential (V) at the LDP recording site to the onset of QRS complex were -50.4+/-18.9, -15.2+/-9.6, and 3.0+/-13.3 ms, respectively. The earliest ventricular activation site during VT was identified at the posteroapical septum and was more apical in the septum than the region with LDP in every patient. In 9 patients, VT entrainment was done by pacing from the right ventricular outflow tract while recording LDP. During entrainment, LDP was orthodromically captured, and as the pacing rate was increased, the LDP-to-PP interval was prolonged, whereas stimulus-to-LDP and PP-to-V interval were constant. In 3 patients, the pressure applied to the catheter tip at the LDP region resulted in conduction block between LDP and PP and in VT termination. RF energy application at the LDP recording site successfully eliminated VT.LDP was suggested to represent the excitation at the entrance to the specialized area with a conduction delay in response to the increase in the rate within the critical slow conduction zone participating in the reentry circuit of this VT. LDP can be a useful marker for successful RF ablation for this VT.
US proposes sweeping changes to guidance on human research
Authors: J. Lenzer
Journal: BMJ (2011)

The US government has proposed an extensive list of changes to current guidelines on studies involving human participants, in a bid to keep pace with substantial change in the nature of such research and the way it is conducted.

If adopted, the changes will be the first in two decades to the “Common Rule” (a part of the Code of Federal Regulations) that regulates almost all federally funded human research. They would apply not only to studies directly funded by the government but also to all research conducted at institutions receiving federal funds, so as to “extend the protections afforded by these …
Assessing Somatization in Functional Gastrointestinal Disorders: Integration of Different Criteria
Authors: Piero Porcelli, Massimo De Carne, Giovanni A. Fava
Journal: Psychotherapy and Psychosomatics (2000)

&lt;i&gt;Background:&lt;/i&gt; Psychiatric assessment of somatization (the tendency to experience and communicate psychological distress in the form of physical symptoms and to seek medical help for them) currently rests on DSM criteria. An alternative diagnostic and conceptual framework has been proposed by an international group of psychosomatic investigators. The aim of this study was to compare these new criteria (Diagnostic Criteria for Psychosomatic Research, DCPR) with DSM-IV in a population where a high prevalence of psychosocial problems is expected (functional gastrointestinal disorders, FGID). &lt;i&gt;Method:&lt;/i&gt; One hundred and ninety consecutive patients with FGID in a tertiary care center were assessed according to DSM-IV and DCPR criteria. &lt;i&gt;Results:&lt;/i&gt; The number of the 12 DCPR diagnoses was almost double that of DSM diagnoses. Only 9% of the patients were not identified by DCPR criteria, whereas this occurred in 25% of patients using DSM criteria. While patients who were given a DSM diagnosis frequently had additional DCPR diagnoses, many patients with DCPR syndromes did not fulfill any DSM criteria. Four DCPR syndromes appared to be particularly frequent and accounted for almost three quarters of the total diagnoses (alexithymia, persistent somatization, functional symptoms secondary to a psychiatric disorder, demoralization). &lt;i&gt;Conclusions:&lt;/i&gt; The joint use of DSM and DCPR criteria was found to improve the identification of psychological factors in FGID. The results may pave the way for changes in DSM classification of somatoform disorders.
The Effects of Psychotherapy on Psychological Well-Being and Diurnal Cortisol Patterns in Breast Cancer Survivors
Authors: Fei-Hsiu Hsiao, Guey-Mei Jow, Wen-Hung Kuo, King-Jen Chang, Yu-Fen Liu, Rainbow T.H. Ho, Siu-Man Ng, Cecilia L.W. Chan, Yu-Ming Lai, Yu-Ting Chen
Journal: Psychotherapy and Psychosomatics (2012)

&lt;i&gt;Background:&lt;/i&gt; Neuroendocrine dysregulation influenced by psychosocial stress is related to breast cancer recurrence. Very few studies examine the impacts of psychotherapy on diurnal cortisol patterns among breast cancer survivors. &lt;i&gt;Methods:&lt;/i&gt; Forty-eight breast cancer patients who completed active cancer treatment were randomly assigned to receive either 8 weekly body-mind-spirit (BMS) group therapy sessions or 1 educational (EDU) session. Self-report measures included the Beck Depression Inventory-II (BDI-II), and the Meaning in Life questionnaire (MLQ) including two subscales: MLQ-Presence and MLQ-Search. Salivary cortisol levels were collected by the subjects in their homes at the time of awakening, 30 and 45 min after awakening, and at 12.00, 17.00, and 21.00 h. Measurement time points include baseline, the 2nd month (completion of BMS therapy), the 5th month, and the 8th month. &lt;i&gt;Results:&lt;/i&gt; There were no significant differences in BDI-II scores (p&gt;0.05) and MLQ-Presence scores (p &gt;0.05) between BMS and EDU groups at baseline or across the three follow-ups. Nevertheless, greater MLQ-Search scores were found in the BMS group compared to the EDU group during the 5th month of follow-up (p &lt;0.01). The higher level of cortisol at 21.00 h (p &lt; 0.01) and a flatter diurnal cortisol pattern were more likely to occur in EDU than in BMS participants (p &lt; 0.05) at the 8th month of follow-up. &lt;i&gt;Conclusion:&lt;/i&gt; BMS group therapy likely contributed to enhancing an active search for meaning in life toward more opportunities for personal growth and to maintaining stable cortisol responses to everyday life stress for breast cancer survivors.
Identification of regional differences in proinflammatory cytokine concentrations in chronic heart failure due to chages cardiomyopathy: A key element in the comprehension of the disease
Authors: Fabio Vilas-Boas, Ricardo Ribeiro dos Santos, Milena B.P. Soares, Joel A. Pinho Filho, Ana Gabriela C. Silva, Adriano D. Oliveira, Antonio M. Azevedo, Fernando Bullos Filho, Gilson S. Feitosa, Edimar A. Bocchi
Journal: Journal of the American College of Cardiology (2003)
Inhibition of proteoglycan synthesis by transforming growth factor beta in anatomically intact articular cartilage of murine patellae.
Authors: P.M van der Kraan, E.L Vitters, W.B van den Berg
Journal: Annals of the Rheumatic Diseases (1992)

The effect of transforming growth factor beta (TGF beta) on proteoglycan synthesis and degradation in anatomically intact articular cartilage of murine patellae was studied. Exogenously added TGF beta up to a concentration of 200 pmol/l had no effect on proteoglycan synthesis in intact articular cartilage. Neutralisation of endogenously produced TGF beta with a specific monoclonal antibody to TGF beta, however, led to stimulation of proteoglycan synthesis, indicating that TGF beta itself inhibits proteoglycan synthesis in anatomically intact cartilage. Transforming growth factor beta decreased the degradation of proteoglycans in intact cartilage in the absence of fetal calf serum or insulin-like growth factor 1. In the presence of fetal calf serum or insulin-like growth factor 1, TGF beta had no additional effect on proteoglycan breakdown.
Lidocaine and Sinus Standstill-Reply
Authors: Dante Antonelli
Journal: JAMA (1983)

In Reply.—  We consider the therapeutic dose of lidocaine  when the drug is given at a dosage of no more than 1 to 2 mg/kg of body weight as bolus and no more than 55 μg/kg/min as maintenance drip infusion. If heart failure and liver disease are present, the dosage must be reduced.  In the case reported by Cheng and Wadhwa (1973;223:790), the patient received 200 mg of lidocaine over five minutes and had severe congestive heart failure; we think that the dose, as previously pointed out by Cacace (1973;224:1428), was excessive and that sinus standstill after lidocaine administration, together with hypotension and convulsions, was the result of the drug overdose.  We agree that lidocaine administration, even at the conventional therapeutic dose, needs caution, especially in elderly patients with congestive heart failure and acute diaphragmatic myocardial infarction.
The Treatment of Asthma with Corticotrophin
Authors: J. E. G. Pearson
Journal: BMJ (1955)

Stimulation of the adrenal cortex by adrenocortico- .trophichormone (corticotrophin, A.C.T.H.) has been used with success in various hypersensitivity conditions, and was the subject of a review by Rackemann (1951).Naturally, asthma has featured among the disorders so treated, and further assessment of its use and possible abuse seems desirable in this condition, which has been increasingly recognized as liable to cause a fatal outcome in severe cases.While cortisone has also been used in trials by mouth, by injection, or by inhalation, its use is not here considered. Present CasesWhen the present series of 10 asthmatic cases was treated, A.C.T.H. was still scarce, and certain strict criteria were imposed before giving such treatment:(1) all were admitted to hospital suffering either from severe status asthmaticus or from prolonged and incapacitating asthma; (2) they showed little or no response to other routine forms of therapy, including intravenous aminophylline; and (3) so far as possible, they were unaware that A.C.T.H. was being given lest the idea of some new magic treatment should play a largely psychological part in any improvement.Most of the cases were so severe that it was felt scarcely justifiable or necessary to risk fatalities by a control series such as that usefully described by Ball (1954).Case 1 A farmer aged 40 had for seven years had repeated infec- tions of the accessory nasal sinuses, requiring operation more than once.Eighteen months before admission he had asthmatic symptoms which were thought to be mainly of infective origin.He entered hospital in a mild status asthmaticus, and treatment, including antispasmodics, penicillin, physiotherapy, and intravenous aminophylline, produced only slight improvement.X-ray examination of his sinuses showed widespread infection; he was producing on an average 1 fl.oz. (28ml.) of purulent sputum daily.A.C.T.H. was started in a dosage of 30 mg. eight-hourly intramuscularly, and within 36 hours he was much less distressed than he had been for many weeks.The dosage was gradually diminished until a total of 510 mg. had been given in seven days.Two days later he was able to return home in quite a comfortable state.He started to relapse after a few weeks, and four months after discharge he had to be readmitted urgently.During bronchoscopy under thiopentone anaesthesia he suddenly collapsed and died, and at necropsy his whole bronchial tree was full of sticky mucopurulent secretion.Case 2 An intelligent and sensible housewife aged 53 was seen at home as an emergency in status asthmaticus so severe that two hours previously her own practitioner had thought her to be on the point of death.In spite of intravenous amino- phylline she was still extremely shocked and distressed in her breathing.She was at once admitted to hospital and given A.C.T.H., 30 mg. intramuscularly six-hourly.Within 12 hours she was comfortable, and within 48 hours she was completely free from wheezing.The total dosage was 730 mg. in nine days.
How Primary Care Practices Can Improve Continuity of Care
Authors: Reena Gupta, Thomas Bodenheimer
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Pulmonary Embolism During Pregnancy
Authors: Gerald L. Evans
Journal: JAMA (1968)

Two cases of massive pulmonary embolism occurring during the first trimester of pregnancy were documented by pulmonary angiography. The reported incidence of pulmonary embolism during pregnancy is exceedingly low. When embolism does occur during pregnancy, it is usually reported to be massive, as it was in our patients. Autopsies in patients with lethal embolism frequently show evidence of prior embolism which, in most cases, had not been clinically suspected. Therefore, a greater suspicion of embolism during pregnancy and a more thorough evaluation of suspected cases is warranted. Pulmonary angiography and radioisotope lung scans have a high degree of diagnostic specificity and should be utilized when indicated. When embolism occurs during pregnancy, protection is mandatory for the duration of pregnancy and the early postpartum period.
LYMPHADENOPATHY ASSOCIATED VIRUS IN AIDS, LYMPHADENOPATHY ASSOCIATED SYNDROME, AND CLASSIC KAPOSI PATIENTS IN GREECE
Authors: G Papaevangelou, J Economidou, J Kallinikos, H Choreimi, T Mandalaki, J Stratigos, D Geroldi, F Barre-Sinoussi, J.C Chermann, L Montagnier
Journal: The Lancet (1984)
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease
Authors: Motomasa Tanaka, Yoko Machida, Sanyong Niu, Tetsurou Ikeda, Nihar R Jana, Hiroshi Doi, Masaru Kurosawa, Munenori Nekooki, Nobuyuki Nukina
Journal: Nature Medicine (2004)
Cervical Tuberculous Lymphadenitis Mimicking Distant Lymph Node Metastasis on F-18 FDG PET/CT in a Patient With Gastric Carcinoid Tumor
Authors: Hae Won Kim, Byung Wook Choi, Kyoung Sook Won, Seok Kil Zeon
Journal: Clinical Nuclear Medicine (2009)

A 35-year-old man was diagnosed with gastric carcinoid tumor and underwent whole body F-18 FDG PET/CT for staging. F-18 FDG PET/CT showed no abnormal uptake in the stomach. However, there was increased uptake in the right cervical lymph nodes. An open biopsy of the lymph node confirmed tuberculous lymphadenitis without malignancy. The increased uptake of cervical lymph nodes on F-18 FDG PET/CT imaging should be interpreted with caution in differentiating benign from malignant lesions and should be confirmed by pathologic examination before the initiation of a definitive treatment.
Asthma in India
Authors: Rebecca Voelker
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Probability of adverse events that have not yet occurred: a statistical reminder
Authors: E. Eypasch, R. Lefering, C K Kum, H. Troidl
Journal: BMJ (1995)

The probability of adverse and undesirable events during and after operations that have not yet occurred in a finite number of patients (n) can be estimated with Hanley's simple formula, which gives the upper limit of the 95% confidence interval of the probability of such an event: upper limit of 95% confidence interval = maximum risk = 3/n (for n > 30). Doctors and surgeons should keep this simple rule in mind when complication rates of zero are reported in the literature and when they have not (yet) experienced a disastrous complication in a procedure.
Effect of flecainide acetate on prevention of electrical induction of ventricular tachycardia and occurrence of ischemic ventricular fibrillation during the early postmyocardial infarction period: Evaluation in a conscious canine model of sudden death
Authors: William H. Kou, Steven D. Nelson, Joseph J. Lynch, Daniel G. Montgomery, Lorenzo DiCarlo, Benedict R. Lucchesi
Journal: Journal of the American College of Cardiology (1987)
Reversal of liver damage due to long term methyltestosterone and safety of non-17 alpha-alkylated androgens.
Authors: C P Lowdell, I M Murray-Lyon
Journal: BMJ (1985)

The patient went on to make an uneventful recovery after seven days of intravenous ceftazidime alone.A specimen of cerebrospinal fluid taken during single drug treatment contained 315 mg ceftazidime/l.The specimen was sterile on culture and both inhibited and killed the standard inoculum of salmonella in vitro at a dilution of 1/32 (table ).The concentration of ceftazi- dime and the inhibitory dilution were both twice that obtained with the lower dose of the drug, and in retrospect there was probably no need to have in- creased the dose when chloramphenicol was discontinued. CommentThese findings are clear evidence of antagonism between the bacteriostatic agent chloramphenicol and the bactericidal ceftazidime and support the view that such combinations are undesirable in the treatment of meningitis.When a cephalosporin such as ceftazidime is used to treat Gram negative meningitis it should not be combined with chloramphenicol.
Natural antibiosis among skin bacteria as a primary defence against infection
Authors: SYDNEY SELWYN
Journal: British Journal of Dermatology (1975)

Antibiotic-producing bacteria were present on the healthy intact skin of 77 of 340 people but predominated in only 38-9% of these. In contrast, antibiotic-producers which occurred in the lesions of 51 out of 263 dermatological patients predominated in 78-4%. The presence of inhibitory commensals in skin lesions was associated with a significantly low incidence of secondary infection both on admission and during hospital stay; there was, however, a small excess of Gram-negative infections on admission in skin lesions containing antibiotic producers. Among ninety surgical patients, also, the presence of inhibitory skin bacteria was associated with a relatively low rate of wound colonization by pathogenic bacteria. The ecological implications and practical applications of the findings are discussed.
PREVALENCE AND CORRELATES OF AORTIC DILATATION IN ADOLESCENTS AND YOUNG ADULTS: THE STRONG HEART STUDY.
Authors: Marina De Marco, Mary J. Roman, Giovanni de Simone, Marcello Chinali, Lyle G. Best, Elisa T. Lee, Damon Dixon, Barbara V. Howard, Richard B. Devereux
Journal: Journal of the American College of Cardiology (2010)
Induction of remission in a patient with Takayasu's arteritis by low dose pulses of methotrexate.
Authors: D Mevorach, G Leibowitz, M Brezis, E Raz
Journal: Annals of the Rheumatic Diseases (1992)

A 42 year old woman with Takayasu9s arteritis responded to treatment with prednisone (60 mg daily) but developed severe side effects. Cyclophosphamide treatment did not produce a clinical improvement or steroid sparing effect. A treatment trial with a weekly pulse of low dose methotrexate improved her symptoms and the patency of her occluded left subclavian artery.
Is there a role for exercise in the prevention of osteoporotic fractures?
Authors: O M Rutherford
Journal: British Journal of Sports Medicine (1999)

OBJECTIVES: To examine whether there is a role for exercise in improving bone mineral density (BMD), particularly in postmenopausal women. The effects of different types of exercise are examined together with their effects at selected skeletal sites. The role of activity in reducing falls and hip fractures will also be considered as well as the potentially negative effects of excessive exercise. METHODS: A literature search over the past 20 years was conducted and landmark papers selected. RESULTS: Certain types of exercise have been found to exert moderate benefits on BMD of the wrist, spine, and hip. Most studies do not detect a difference between the effects of endurance activities and strength training for BMD of the spine. It has been more difficult to isolate the optimal type of activity for effecting an osteogenic response at the hip, but recent evidence suggests that high impact work such as stepping and jumping may be effective at this site. The combination of hormone replacement therapy and exercise would appear to be more effective than either intervention on its own. Certain types of exercises have additional benefits, such as muscle strengthening, which could reduce the incidence of falls. Excessive exercise can lead to menstrual disturbances in female athletes and this in turn can cause bone loss, particularly from the spine. CONCLUSIONS: Exercise across the life span should be encouraged in order to maximise peak bone mass, reduce age related bone loss, and maintain muscle strength and balance. Although the effects of exercise on BMD later in life are small, epidemiological evidence suggests that being active can nearly halve the incidence of hip fractures in the older population. This effect is most probably multifactorial through the positive effects on bone, muscle strength, balance, and joint flexibility. Younger women should be aware of the dangers to the skeleton of menstrual disorders.