tbuckley/cabot-search huggingface dataset:
Biomarkers for Detecting and Risk-Stratifying Chronic Kidney Disease
Authors: Lei Zhao
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prolonged recovery of renal function after prostatectomy for prostatic outflow obstruction.
Authors: R R Ghose
Journal: BMJ (1990)

rhythm disorders no other drugs known to prolong the Q-T interval and induce torsades de pointes-for example, diuretics or antiarrhythmics-had been given.Antibiotic treatment was changed to ciprofloxacin.No further arrhythmia occurred and the patient was discharged three weeks later.
Anatomically Restricted Synergistic Antiviral Activities of Innate and Adaptive Immune Cells in the Skin
Authors: Heather D. Hickman, Glennys V. Reynoso, Barbara F. Ngudiankama, Erica J. Rubin, Javier G. Magadán, Stephanie S. Cush, James Gibbs, Barbara Molon, Vincenzo Bronte, Jack R. Bennink, Jonathan W. Yewdell
Journal: Cell Host & Microbe (2013)
More treatment in surgeries and at home will help cut NHS carbon footprint
Authors: A. Cole
Journal: BMJ (2009)

The UK health department unveiled a radical package of measures this week designed to reduce the carbon footprint of the NHS. Currently, the service is responsible for more than 3% of all emissions in England.

The department’s strategy includes proposals to reduce meat and dairy products in hospital food, reuse more medical equipment, and bring health care closer to the home and general practice.

The report, launched on Tuesday, says that urgent action is needed to achieve the government’s 2015 target for the NHS of a 10% carbon reduction. The longer term target is an 80% cut by 2050.

The NHS currently emits …
New Zealand GPs divide over contracts
Authors: C. Williams
Journal: BMJ (1995)

<b>Background/aim:</b> Sub-Tenon’s block (STB) or topical anaesthesia alone (TOP) are popular techniques employed during cataract surgery. TOP is often preferred by healthcare providers because of financial or staffing reasons, despite existing evidence that pain during surgery is better controlled with STB. Pain is not the only consideration that determines patient preference for the anaesthesia technique. The authors decided to investigate the issue of patient satisfaction using the recently developed Iowa Satisfaction with Anesthesia Scale (ISAS). <b>Method:</b> In a randomised controlled pilot trial, 28 patients were enrolled to receive either STB with 3 ml of 2% lidocaine and hyaluronidase, or TOP with proxymetacaine 0.5% and amethocaine 1% (Tetracaine) eye drops. Postoperatively patients rated their satisfaction with anaesthesia care by filling in the self administered written questionnaire, the ISAS. <b>Results:</b> One patient in the TOP group dropped out of the study because of intolerable pain. Analysis of the questionnaire results with a two sample Wilcoxon rank sum test showed a significant difference in patient satisfaction (p&lt;0.0085). The median satisfaction score was higher in the STB group 2.77 (interquartile range IQR 2.45 to 3), than in the TOP group 2.04 (IQR 1.54 to 2.5). <b>Conclusion:</b> In the setting of day case cataract surgery, patients report significantly higher satisfaction scores with STB than with TOP alone.
Squamous papilloma of the anal canal
Authors: J. Gerada, A. Savic, M. Vassallo
Journal: Endoscopy (2013)

Squamous papillomas of the gastrointestinal tract are usually limited to the oral cavity [1], oropharynx [1], and the esophagus [2] [3]; squamous papilloma of the anal canal is a rare entity. We report a case of a squamous papilloma of the anal canal, initially suspected to be a fibroepithelial anal polyp.
Photo-induced toxic epidermal necrolysis caused by clobazam
Authors: P. REDONDO, J. VICENTE, A. ESPANA, M.L. SUBIRA, I. DE FELIPE, E. QUINTANILLA
Journal: British Journal of Dermatology (1996)

Toxic epidermal necrolysis (TEN) is a life‐threatening disease, the pathogenesis of which remains largely unknown. We describe a 23‐year‐old woman under treatment with clobazam who developed lesions of TEN In light‐exposed areas. Patch and photopatch tests with clobazam were negative. The cellular phenotype and cytokines were studied in blister fluid. The cellular infiltrate was composed mainly of T lymphocytes with a predominant cyloloxic phenotype. Tbere was an increase in the level of tumour necrosis factor (TNF)‐α in blister fluid compared with the control (a patient with bullous pemphigoid).
Abstract 2230: Gene mutations and deletions inactivates PTEN tumor suppressor in Chilean colon cancer patients
Authors: Gonzalo Encina, Karin Alvarez, Paulina Orellana, Ana María Wielandt, Cynthia Villarroel, Daniela Simian, Luis Contreras, Udo Kronberg, Francisco López, Pilar Carvallo
Journal: Cancer Research (2014)

Abstract Introduction. Tumor suppressor PTEN acts as a negative regulator of the PI3K/AKT/mTOR pathway, thus controlling cell survival and proliferation. Mutations or deletions inactivating PTEN function lead to over-activation of the PI3K/AKT/mTOR pathway in cancer. PTEN gene alterations have been described in different types of tumors. In colon cancer these mutations range from 1% to 29% of the cases. The aim of this study was to determine the prevalence of PTEN mutations and/or deletions in Chilean colon cancer patients. Methods: ninety-one colon cancer patients were recruited for this study. Genomic DNA from normal and tumor tissue was obtained, and the deletion of PTEN locus was determined by PCR amplification of three STR markers flanking PTEN, and two intragenic markers. To search point mutations we amplified exons 7 and 8 by PCR, and sequenced. PTEN expression was evaluated through immunohistochemistry. Results: We observed deletion events in 9.8% (9/91) of tumors, and inactivating mutations in 5.5% (5/91). Two tumors presented a deletion in one allele and a mutation in the other. Immunohistochemistry detected a very weak expression of PTEN in 55/76 tumors. Conclusions: 15.4 % (12/91) of tumors have PTEN gene inactivated. We observed that deletion was a frequent mechanism for PTEN inactivation in Chilean colon cancer patients. Note: This abstract was not presented at the meeting. Citation Format: Gonzalo Encina, Karin Alvarez, Paulina Orellana, Ana María Wielandt, Cynthia Villarroel, Daniela Simian, Luis Contreras, Udo Kronberg, Francisco López, Pilar Carvallo. Gene mutations and deletions inactivates PTEN tumor suppressor in Chilean colon cancer patients. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2230. doi:10.1158/1538-7445.AM2014-2230
An Animal Model of Myopia
Authors: Elio Raviola, Torsten N. Wiesel
Journal: New England Journal of Medicine (1985)

Myopia develops in macaque monkeys when their lids are surgically fused at birth and kept closed for one year. This experimental refractive error has many features in common with human myopia: It is caused by progressive axial elongation of the eye, is often accompanied by fundus changes, and can only be induced before eye growth has been completed. Myopia does not develop in animals raised in the dark; thus, it is triggered by an alteration of the visual input and is presumably mediated by the nervous system. In Macaca arctoides, atropine administration prevents abnormal eye elongation, and this suggests that lid-fusion myopia is caused by excessive accommodation. In M. mulatta, atropine is ineffective; furthermore, myopia develops when lids are sutured after interruption of the optic pathways. Thus, in this species accommodation can be ruled out as a determinant of eye elongation, and other neural mechanisms may be responsible for the refractive error. Our experiments suggest that the refractive state is largely programmed on a genetic basis, but that an abnormal visual experience can disrupt the process of postnatal eye growth and induce axial myopia.
TCT-465 Safety and efficacy of intracoronary bivalirudin administration during primary angioplasty in comparison with a standard treatment with heparin and provisional GP2b3a inhibitors
Authors: Alessandro Lupi, Gioel G. Secco, Andrea Rognoni, Italo Porto, Maurizio Lazzero, Angelo S. Bongo
Journal: Journal of the American College of Cardiology (2014)
POSITRON EMISSION TOMOGRAPHY (PET), COMPUTED TOMOGRAPHY (CT), AND MONOCLONAL ANTIBODY SCAN (MAb) FOR EVALUATION OF LYMPH NODE METASTASES IN PATIENTS WITH PROSTATE SPECIFIC ANTIGEN (PSA) RELAPSE AFTER TREATMENT FOR LOCALIZED PROSTATE CANCER.
Authors: M. Seltzer, J. Naitoh, J. deKernion, A. Belldegrun, M. Phelps, C. Hoh
Journal: Clinical Nuclear Medicine (1998)
Doctors to get new warning system on complaints
Authors: Z. Kmietowicz
Journal: BMJ (2001)

The General Medical Council is introducing a new warning system to discipline doctors whose behaviour falls short of what is deemed “good medical practice” but is not severe enough to warrant a hearing before the Professionals Complaints Committee.

The new level of complaint is designed to quieten critics of the GMC who have accused the council of dealing with only very serious offences by doctors, while allowing more minor misdemeanours to go unchecked—leaving …
A passing age
Authors: Kevin Barraclough
Journal: BMJ (2004)

The generation that I think I most respect is dying out. Throughout my career I have listened to the stories of old people who lived through extraordinary times. They were touched by a kind of insouciant nobility of the kind caught only on the edge of reluctant sentences. The man, put ashore from the Hood with appendicitis, still guilty about being an accidental survivor. The code breakers and spies who kept their secrets all their lives merely …
Blindness of an Adult Caused by Oxygen
Authors: Tsutomu Kobayashi
Journal: JAMA (1972)

A 32-year-old man suffering from myasthenia gravis developed a retinal atrophy after 150 days of hyperoxia through artificial ventilation with 80% oxygen. The atrophy resulted from a constriction of the retinal artery, and the patient lost the sight of both eyes. This case might be the first reported irreversible retinal damage in an adult human induced by excessive oxygen.
A CASE OF LYMPHANGIOMA CIRCUMSCRIPTUM
Authors: PAUL E. BECHET
Journal: JAMA (1913)

The following case of lymphangioma circumscriptum, a comparatively rare dermatosis, occurred in the service of Dr. Jerome Kingsbury at the New York Skin and Cancer Hospital, and was presented by him at one of the recent meetings of the New York Dermatologic Society. The patient, M. D., schoolgirl, aged 13, has never had any acute illness, other than an attack of rubeola when 9 months old. Her family history is negative; her father, mother, three sisters and three brothers are perfectly healthy, and entirely free from angiomatous, or other dermatologic lesions. The patient is in good health, but occasionally suffers from indigestion. The disease began when she was 3 years old, first as a reddish inflamed patch, on which, in a very short time, vesicles appeared. The lesion slowly increased in size until four or five years ago; since then it has remained stationary. There are no subjective sensations, but
Diagnosis for Diphenylhydantoin
Authors: LARRY D. CROOK
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 November 1973Diagnosis for DiphenylhydantoinLARRY D. CROOK, M.D.LARRY D. CROOK, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-5-755_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the recent article, "Islet Cell Tumors: Current Concepts and Management," (Ann Intern Med79:239-257, 1973) the authors state, "in patients with undiagnosed seizure disorders, however, this drug [diphenylhydantoin] may partially mask both the clinical and diagnostic chemical features of insulinoma." It is hoped that patients will not be given diphenylhydantoinwithouta diagnosis.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: USAF Clinic APO NY 09121 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1973Volume 79, Issue 5Page: 755-756KeywordsDrugsEpilepsyInsulinoma Issue Published: 1 November 1973 PDF downloadLoading ...
Bcl-2 Is a Prognostic Marker in Breast Cancer Independently of the Nottingham Prognostic Index
Authors: Grace M. Callagy, Paul D. Pharoah, Sarah E. Pinder, Forrest D. Hsu, Torsten O. Nielsen, Joseph Ragaz, Ian O. Ellis, David Huntsman, Carlos Caldas
Journal: Clinical Cancer Research (2006)

Abstract Purpose: Prognostication of breast cancer using clinicopathologic variables, although useful, remains imperfect. Many reports suggest that gene expression profiling can refine the current approach. Alternatively, it has been shown that panels of proteins assessed by immunohistochemistry might also be useful in this regard. We evaluate the prognostic potential of a panel of markers by immunohistochemistry in a large case series to establish if either a single marker or a panel could improve the prognostic power of the Nottingham Prognostic Index (NPI). We validated the results in an independent series. Experimental Design and Results: The expression of 13 biomarkers was evaluated in 930 breast cancers on a tissue microarray. Eight markers [estrogen receptor (ER), progesterone receptor (PR), Bcl-2, cyclin E, p53, MIB-1, cytokeratin 5/6, and HER2] showed a significant association with survival at 10 years on univariate analysis. On multivariate analysis that included these eight markers and the NPI, only the NPI [hazard ratio (HR), 1.35; 95% confidence interval (95% CI), 1.16-1.56; P = 0.0005], ER (HR, 0.59; 95% CI, 0.39-0.88; P = 0.011), and Bcl-2 (HR, 0.68; 95% CI, 0.46-0.99; P = 0.055) were significant. In a subsequent multivariate analysis that included the NPI, ER, and Bcl-2, only Bcl-2 (HR, 0.62; 95% CI, 0.44-0.87; P = 0.006) remained independent of NPI (HR, 1.50; 95% CI, 1.16-1.56; P = 0.004). In addition, Bcl-2, used as a single marker, was more powerful than the use of a panel of markers. Based on these results, an independent series was used to validate the prognostic significance of Bcl-2. ER and PR were also evaluated in this validation series. Bcl-2 (HR, 0.83; 95% CI, 0.71-0.96; P = 0.018) retained prognostic significance independent of the NPI (HR, 2.04; 95% CI, 1.67-2.51; P &amp;lt; 0.001) with an effect that was maximal in the first 5 years. Conclusion: Bcl-2 is an independent predictor of breast cancer outcome and seems to be useful as a prognostic adjunct to the NPI, particularly in the first 5 years after diagnosis.
PET/CT Findings in a Case With FDG-Avid Disseminated Lacrimal Gland MALToma With Sequential Development of Large B-Cell Lymphoma and Gastric MALToma
Authors: Nilufer Yildirim-Poyraz, Elif Ozdemir, Abdulkadir Basturk, Aydan Kilicarslan, Seyda Turkolmez
Journal: Clinical Nuclear Medicine (2014)

Primary orbital lymphomas are rare; the major histopathologic type is extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) or MALToma. We present a case of a 79-year-old female patient with FDG-avid lacrimal gland MALToma with nodal and pulmonary involvement (stage IVE). Nasopharynx and gastric involvement were detected on restaging F-FDG PET/CT after rituximab therapy, and it was found to have a site of transformation to diffuse large B-cell lymphoma (DLBCL) in the nasopharynx. Gastric MALT lymphoma was also confirmed histopathologically, and she then underwent combination chemotherapy regimen, resulting in regression after 3 courses.
Lymphomatoid papulosis with 6p25.3 rearrangement: a further case of the newly described variant
Authors: J. Kluk, F. Child, A. Robson
Journal: British Journal of Dermatology (2014)

Funding sources: none. Conflicts of interest: none declared. Dear Editor, A 67‐year‐old woman presented with a 6‐month history of recurrent erythematous papules on her face and scalp, persisting for approximately 6 weeks before resolving spontaneously without scarring. Examination revealed two nonspecific excoriated erythematous papules on the vertex of her scalp (Fig. 1a,b) and a subtle, poorly defined, nonscaly erythematous patch on the anterolateral aspect of her neck (Fig. 1c). She was systemically well with no B symptoms, lymphadenopathy or hepatosplenomegaly. There was no personal history of skin disease, malignancy or immunosuppression and no family history of note. Her full blood count, lymphocyte subsets, lactate dehydrogenase, and HIV and human T‐lymphotropic virus type I serology were all normal or negative. A skin biopsy of a facial papule demonstrated a nodular dermal lymphoid infiltrate. The epidermis was nonulcerated, hyperplastic and peppered with atypical small‐ to medium‐sized mononuclear cells with irregular nuclei in a pagetoid reticulosis pattern. Occasional intraepidermal nests of lymphocytes, similar to the Pautrier microabscesses of mycosis fungoides, were also noted (Fig. 2a). The atypical cells in the dermis were medium to large in size with hyperchromatic, irregular nuclei and abundant finely granular cytoplasm (Fig. 2b). The atypical cells had a CD3+, CD4−, CD8−, CD2−, CD5+ immunophenotype and showed diffuse strong expression of CD30 (Fig. 2c). ALK‐1, epithelial membrane antigen (EMA), T‐cell intracytoplasmic antigen 1 (TIA‐1), CD56, granzyme B and Epstein–Barr virus‐encoded RNA were negative and Ki‐67 was > 95%. T‐cell receptor gene analysis confirmed nonidentical clonal rearrangements in the skin and blood. Fluorescence in situ hybridization (FISH) analysis of the DUSP22‐IRF4 locus demonstrated separation of centromeric (green) and telomeric (red) fluorescent signals confirming a translocation involving 6p25.3 (Fig. 2d), and a diagnosis of the primary cutaneous CD30‐positive lymphoproliferative disorder, lymphomatoid papulosis (LyP) with 6p25.3 rearrangement, was made.
Sampling pure fetal blood by fetoscopy in second trimester of pregnancy.
Authors: C H Rodeck, S Campbell
Journal: BMJ (1978)

A technique for fetal blood-sampling in the second trimester of pregnancy (between 16 and 22 weeks9 gestation) combining fetoscopy with real-time ultrasound was used in 48 attempts at fetal blood-sampling. Specimens containing fetal red cells with or without amniotic fluid or maternal blood, and adequate for diagnosing haemoglobinopathies, were obtained in 45 of the 48 fetoscopies. Sampling was successful in all 18 patients with a posterior placenta, and in 27 of the 30 with an anterior placenta. In 22 of the last 27 consecutive fetoscopies pure fetal blood was taken; the placenta was anterior in 16 and posterior in six. Out of 17 cases sampled between 18 and 22 weeks9 gestation pure fetal blood was obtained in 16. The volume of the samples varied from 50 to 500 microliter. The ability to obtain pure fetal blood consistently even when the placenta is anterior will increase knowledge of fetal physiology and the scope of prenatal diagnosis.
Dietary modifiers of carcinogenesis.
Authors: L Kohlmeier, N Simonsen, K Mottus
Journal: Environmental Health Perspectives (1995)

Dietary components express a wide range of activities that can affect carcinogenesis. Naturally occurring substances in foods have been shown in laboratory experiments to serve as dietary antimutagens, either as bioantimutagens or as desmutagens. Dietary desmutagens may function as chemical inactivaters, enzymatic inducers, scavengers, or antioxidants. Dietary components may also act later in the carcinogenic process as tumor growth suppressors. Examples of dietary factors acting in each of these stages of carcinogenesis are presented, and potential anticarcinogens such as the carotenoids, tocopherols, phenolic compounds, glucosinolates, metal-binding proteins, phytoestrogens, and conjugated linoleic acid are discussed. Individual foods typically contain multiple potential anticarcinogens. Many of these substances can influence carcinogenesis through more than one mechanism. Some substances exhibit both anticarcinogenic and carcinogenic activity in vitro, depending on conditions. Epidemiologic research indicates that high fruit and vegetable consumption is associated with lower cancer risk. Little research has focused on the effects of single substances or single foods in man. Realization of the potential of foodborne substances to reduce the human burden of cancer will only be achieved with better measurement of dietary exposures and funding of multidisciplinary research in this area commensurate with its importance.
Long-term outcome of hepatitis B e antigen-positive patients with compensated cirrhosis treated with interferon alfa
Authors: G Fattovich, G Giustina, G Realdi, R Corrocher, S W Schalm
Journal: Hepatology (1997)

The aim of this study was to evaluate whether interferon alfa (IFN-α) treatment-associated virological and biochemical remission improves survival in a cohort of 90 white patients with compensated cirrhosis caused by hepatitis B (Child A) followed for a mean period of 7 years. Inclusion criteria were biopsy-proven cirrhosis, hepatitis B e antigen (HBeAg) positivity, abnormal serum aminotransferase levels, exclusion of hepatitis delta virus, and absence of complications of cirrhosis. Of the 40 IFN-treated patients, 27 (67%) showed sustained HBeAg loss with alanine aminotransferase (ALT) normalization. Of the 50 untreated patients, 30 (60%) cleared HBeAg, but only 21 (42%) normalized ALT after HBeAg loss. Compared with the untreated patients, IFN-treated patients had similar cumulative rates of HBeAg clearance ( P = .48), but higher rates of ALT normalization ( P = .016) and of HBsAg loss ( P = .028). During follow-up, liver-related death occurred in 8 treated patients, caused by liver failure in 5 and hepatocellular carcinoma (HCC) in 3; all 8 had continued to be HBeAg-positive with elevated ALT. None of the treated patients undergoing remission developed liver-related complications. At univariate analysis, life expectancy was longer in treated patients showing sustained remission than in those who did not (5-year survival: 100% vs. 81%; P = .048). Fourteen untreated patients died (from liver failure in 10 and HCC in 4); all but 3 had continued to be HBeAg-positive with elevated ALT. Cox's model identified age and ALT normalization as the only significant predictors of survival. In conclusion, in patients with HBeAg-positive compensated cirrhosis, virological and biochemical remission following IFN therapy is associated with improved survival.