Aspartame-lnduced Urticaria
Authors: ANTHONY KULCZYCKI
Journal: Annals of Internal Medicine (1986)

Brief Reports1 February 1986Aspartame-lnduced UrticariaANTHONY KULCZYCKI Jr., M.D.ANTHONY KULCZYCKI Jr., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-2-207 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAspartame (NutraSweet; G.D. Searle & Co., Skokie, Illinois), the dipeptide composed of aspartic acid and the methyl ester of phenylalanine, is a low-calorie artificial sweetener 180 times sweeter than sucrose (1, 2). Although questions have been raised about its safety (3-5), the Food and Drug Administration (FDA) approved aspartame for use in carbonated beverages in 1983, and currently it is used extensively in diet soft drinks, chewing gums, cereals, desserts, and sugar substitutes. One case of granulomatous panniculitis resulting from aspartame has been documented (6). This report describes a case of aspartame-induced urticaria confirmed by doubleblind challenge.A 23-year-old white...References1. MAZURSCHLATTERGOLDKAMP RJA. Structure-taste relationships of some dipeptides. J Am Chem Soc. 1969;91:2684-91. CrossrefMedlineGoogle Scholar2. MAZUR R. Aspartame—a sweet surprise. J Toxicol Environ Health. 1976;2(l):243-9. CrossrefMedlineGoogle Scholar3. WURTMAN R. Neurochemical changes following high-dose aspartame with dietary carbohydrates [Letter]. N Engl J Med. 1983;309:429-30. CrossrefMedlineGoogle Scholar4. OLNEY J. Excitotoxic food additives—relevance of animal studies to human safety. Neurobehav Toxicol Teratol. 1984;6:455-62. MedlineGoogle Scholar5. GRAVES F. HOW safe is your diet soft drink? Common Cause Mag. 1984;July/Aug:25-43. Google Scholar6. NOVICK N. Aspartame-induced granulomatous panniculitis. Ann Intern Med. 1985;102:206-7. LinkGoogle Scholar7. RANNEYOPPERMANMULDOONMCMAHON RJEF. Comparative metabolism of aspartame in experimental animals and humans. J Toxicol Environ Health. 1976;2:441-51. CrossrefMedlineGoogle Scholar8. . Food additives permitted for direct addition to food for human consumption; aspartame. Federal Register. 1983;48(132):31376-82. Google Scholar9. BOEHMBADA MJ. Racemization of aspartic acid and phenylalanine in sweetener aspartame at 100 °C. Proc Natl Acad Sci USA. 1984;81:5263-6. CrossrefMedlineGoogle Scholar10. PARKER C. Mechanisms of penicillin allergy. In: Pathobiologic Annual. New York: Appleton-Century-Crofts; 1972:405-17. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington University School of Medicine St. Louis, Missouri PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAllergy to food additivesArtificial sweetenersFood allergy: A practice parameter update—2014Allergic reaction caused by acesulfame potassium in foodsUrticaria, Angioedema, and Anaphylaxis Provoked by Food AdditivesUrticariaDrug ReactionsReport of the meeting on Aspartame with National ExpertsAdverse immunological effects of drugs other than anticance drugs and drugs used in immunologyDrug interactionsHypersensitivity reactions to food additivesAspartame: A Safety Evaluation Based on Current Use Levels, Regulations, and Toxicological and Epidemiological StudiesLow-calorie Sweeteners and Other Sugar Substitutes: A Review of the Safety IssuesFood allergy: a practice parameterArtificial sweetenersAspartame 22839-47-0Adverse reactions to food additivesAspartame: Review of SafetyUrtikaria und Nahrungsmittelallergien bzw.-intoleranzenAspartame: Scientific Evaluation in the Postmarketing PeriodThe Nutrients – Deficiencies, Surfeits, and Food-Related DisordersFood Sensitivities: Allergies and IntolerancesRole of nonallergic hypersensitivity reactions in children with chronic urticariaAllergic reactions to foodsIntolérance aux additifs alimentaires chez l'enfant : mythe ou réalité ?ADVERSE REACTIONS TO FOOD AND DRUG ADDITIVESFood and drug additives: hypersensitivity and intoleranceAspartame-induced hivesUrtikaria und Nahrungsmittelallergien bzw. -intoleranzenMiscellaneous drugs and agentsAspartame-induced lobular panniculitisA combined single-blind, double-blind, placebo-controlled study to determine the reproducibility of hypersensitivity reactions to aspartameAspartame-induced lobular panniculitisSampling and Analytical Method for Workplace Monitoring of Aspartame in AirPharmaceutical ExcipientsUrticaria—a challenge in diagnosis and treatmentAspartame and HeadacheMonitoring of Adverse Reactions to Aspartame Reported to the U.S. Food and Drug AdministrationAspartame and Susceptibility to HeadacheNatural food constituents and food additives: The pharmacologic connectionMigraine Provoked by Aspartame 1 February 1986Volume 104, Issue 2Page: 207-208KeywordsAspartameDietFoodFood and Drug AdministrationIngestionNutritionPhenylalanineSafetySucroseUrticaria Issue Published: 1 February 1986 PDF downloadLoading ...