tbuckley/cabot-search huggingface dataset:
Immune Thrombocytopenia and Crohn's Disease
Authors: M. A. Kosmo, G. Bordin, P. Tani, R. Mcmillan
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 January 1986Immune Thrombocytopenia and Crohn's DiseaseM. A. KOSMO, M.D., G. BORDIN, M.D., P. TANI, B.A., R. MCMILLAN, M.D.M. A. KOSMO, M.D., G. BORDIN, M.D., P. TANI, B.A., R. MCMILLAN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-1-136_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Immune thrombocytopenia is sometimes associated with other immune-related diseases (1-3). We report a case of Crohn's disease associated with immune thrombocytopenia.A 65-year-old woman with Crohn's disease since 1950 has a left hemicolectomy and colostomy in 1953 and a right hemicolectomy with an ileosigmoid anastomosis in 1971. Her blood counts were normal until March 1978, when she developed bloody diarrhea. Laboratory findings at that time were a platelet count of 100 000/µL, hemocrit of 31%, and leukocyte count of 9000/µL. She was started on a regimen of prednisone (40 mg/d), hydrocortisone enemas, and sulfasalazine. Her symptoms alleviated,...References1. BUDMANSTEINBERG DA. Hematologic aspects of systemic lupus erythematosus. Ann Intern Med. 1977;86:220-9. LinkGoogle Scholar2. KADENROSSEHAUCH BWT. Immune thrombocytopenia in lymphoproliferative disease. Blood. 1979;53:545-51. CrossrefMedlineGoogle Scholar3. EVANSTAKAHASHIDUANEPAYNELIU RKRRC. Primary thrombocytopenic purpura and acquired hemolytic anemia. Arch Intern Med. 1951;87:48-65. CrossrefGoogle Scholar4. HODGSONPOTTERJEWELL HBD. Immune complexes in ulcerative colitis and Crohn's disease. Clin Exp Immunol. 1977;29:187-96. MedlineGoogle Scholar5. KEMLERALPERT BE. Inflammatory bowel disease associated with circulating immune complexes. Gut. 1980;21:195-201. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAssociation of Immune Thrombocytopenia and Inflammatory Bowel Disease in ChildrenImmune Thrombocytopenic Purpura (ITP) as an Uncommon Extraintestinal Complication of Crohn's Disease: Case Vignette and Systematic Literature ReviewSuccessful Eltrombopag treatment of refractory idiopathic thrombocytopenic purpura associated with Crohn diseaseA rare case of gastric Crohn's disease associated with immune thrombocytopenic purpuraEvaluation of Association Between Precolectomy Thrombocytosis and the Occurrence of Inflammatory Pouch DisordersDisorders of Megakaryocytes and PlateletsPúrpura trombocitopénica idiopática como manifestación extraintestinal de la enfermedad de CrohnColitis ulcerosa asociada a púrpura trombocitopénica idiopática 1 January 1986Volume 104, Issue 1Page: 136-136KeywordsBlood countsColectomyColostomyCrohn's diseaseDiarrheaIdiopathic thrombocytopenic purpuraMedical servicesPlateletsResearch laboratories Issue Published: 1 January 1986 PDF DownloadLoading ...
Human-amnion-tissue Culture in the Routine Virus Laboratory
Authors: I. B. R. Duncan, E. J. Bell
Journal: BMJ (1961)

CYCLICAL OEDEMA,B JO 863 a dosage as low as 15 mg.daily.Whatever the physiological implications may be, the practical manage- ment of cyclical oedema seems to be more effectively and conveniently carried out by the use of oral diuretics such as chlorothiazide.It should be remembered, how- ever, that premenstrual tension is a syndrome of which oedema is the important objective sign, and relief of the various subjective symptoms may be obtained on occasions by a variety of agents. SummaryThe effect of progesterone and norethisterone on urinary electrolyte excretion has been studied in four cases of cyclical oedema.Progesterone caused an increase in urinary sodium excretion, whereas norethisterone produced a tendency to sodium retention.The action of progesterone in a case of hepatic cirrhosis with ascites was similar to that of the aldosterone antagonist spironolactone.The implications of these findings in the treatment of premenstrual tension are discussed.
Smallpox Virus Destruction Delayed Yet Again
Authors: Charles Marwick
Journal: JAMA (1995)

THE PERILS of Pauline are nothing to the vicissitudes that are befalling variola. The 15-year-long maneuvering involved in getting everyone to agree to destroy the remaining stocks of the world's smallpox virus—stored in the United States and in Russia—has run into yet another hitch. The virus' destruction was originally scheduled by the World Health Organization (WHO) for December 1993, after its molecular structure had been sequenced. Destruction was delayed because some scientists believed that keeping the live virus offered opportunities for further research, and the date was set for June 1995 (<i>JAMA</i>. 1993;270:2908). Now the final date has been delayed again. The executive board of the WHO, sensing a difference of opinion among the delegates on the committee charged with deciding the virus' fate, has recommended that a vote for decision not be brought to the WHO general assembly until a greater consensus is obtained, according to a US government
Reassessment of the lethal London fog of 1952: novel indicators of acute and chronic consequences of acute exposure to air pollution.
Authors: M L Bell, D L Davis
Journal: Environmental Health Perspectives (2001)

This article develops and assesses novel indicators of respiratory and other morbidity and mortality following London's lethal smog in the winter of 1952. Public health insurance claims, hospital admission rates for cardiac and respiratory disease, pneumonia cases, mortality records, influenza reports, temperature, and air pollutant concentrations are analyzed for December-February 1952-1953 and compared with those for the previous year or years. Mortality rates for the smog episode from December 1952 to February 1953 were 50-300% higher than the previous year. Claims that the smog only elevated health risks during and immediately following the peak fog 5-9 December 1952 and that an influenza epidemic accounted fully for persisting mortality increases in the first 2 months of 1953 are rejected. We estimate about 12,000 excess deaths occurred from December 1952 through February 1953 because of acute and persisting effects of the 1952 London smog. Pollution levels during the London smog were 5-19 times above current regulatory standards and guidelines and approximate current levels in some rapidly developing regions. Ambient pollution in many regions poses serious risks to public health.
Tough times for dualists
Authors: Merlin Donald
Journal: Behavioral and Brain Sciences (1995)

Abstract Images of mind marks a new era in human cognitive neuroscience. Despite the difficult conceptual problems associated with using group-averaged data and paired subtractions, human PET images converge well with existing data from other areas of cognitive neuroscience while opening up new theoretical and experimental possibilities. However, greater attention to individual differences might prove necessary in the study of culturally driven adaptations such as literacy.
Localization of Heparin-Binding Epidermal Growth Factor–Like Growth Factor in Human Coronary Arteries
Authors: Atsuyuki Nakata, Jun-ichiro Miyagawa, Shizuya Yamashita, Makoto Nishida, Ritsu Tamura, Katsumi Yamamori, Tadashi Nakamura, Shuichi Nozaki, Kaoru Kameda-Takemura, Sumio Kawata, Naoyuki Taniguchi, Shigeki Higashiyama, Yuji Matsuzawa
Journal: Circulation (1996)

Background Heparin-binding epidermal growth factor (EGF)–like growth factor (HB-EGF) is a newly identified member of the EGF family. Our previous in vitro studies showed that HB-EGF is a potent mitogen and chemoattractant for vascular smooth muscle cells (SMCs), suggesting the role of HB-EGF in the pathogenesis of atherosclerosis. The purposes of the present study were to investigate the localization of HB-EGF in both normal and atherosclerotic human coronary arteries and to elucidate the possible roles of this growth factor in the formation of atherosclerotic lesions. Methods and Results The immunohistochemical localization of HB-EGF, SMCs, macrophages, and EGF receptors (EGFRs) was examined in human coronary arteries obtained at autopsy. The medial SMCs of coronary arteries in neonates, infants, and children consistently synthesized HB-EGF protein. In normal adults, however, the relative number of HB-EGF–positive medial SMCs decreased gradually with age after about 30 years of age. In nonatherosclerotic coronary arteries with diffuse intimal thickening, SMCs of the intima, especially those located in the area of the medial side of the intima, were strongly positive for HB-EGF protein. In atherosclerotic plaques of coronary arteries with eccentric intimal thickening, both SMCs and macrophages in and around the core lesions, in addition to the intimal and medial SMCs located adjacent to the plaque, produced HB-EGF protein. A strong immunostaining of EGFRs was observed in these SMCs, suggesting a close association of HB-EGF and EGFR expression. Conclusions These data suggest that HB-EGF might play important roles in the migration of SMCs from the media to the intima, the proliferation of intimal SMCs, and the interaction between SMCs and macrophages in the process of coronary atherogenesis.
Myocardial perfusion imaging by contrast echocardiography with use of intracoronary sonicated albumin in humans
Authors: Shimon A. Reisner, Ling S. Ong, Gerson S. Lichtenberg, Antonio F. Amico, Janine R. S, Mark N. Allen, Richard S. Meltzer
Journal: Journal of the American College of Cardiology (1989)
The Koro Pattern of Depersonalization in an American Schizophrenic Patient
Authors: J. GUY EDWARDS
Journal: American Journal of Psychiatry (1970)

The author distinguishes the "koro pattern of depersonalization" from "koro," the folk illness. The former is probably universal in its distribution and more common than generally supposed; an example in an American schizophrenic is described. The interpretation of the sensation of penile shrinkage varies from culture to culture and age to age. In certain Eastern countries folk belief allows for the occurrence of "koro," although formerly the experience may have been regarded as due to witchcraft.
Deprivation and emergency admissions for cancers of colorectum, lung, and breast in south east England: ecological study
Authors: A. M Pollock, N. Vickers
Journal: BMJ (1998)

To examine the relation between deprivation and acute emergency admissions for cancers of the colon, rectum, lung, and breast in south east England.Ecological analysis with data from hospital episode statistics and 1991 census.North and South Thames Regional Health Authorities (population about 14 million), divided into 10 aggregations of 31 470 census enumeration districts (median population 462).146 639 admissions relating to 76 552 patients aged <100 years on admission, resident in the Thames regions, admitted between 1 April 1992 and 31 March 1995.Residents living in deprived areas were more likely to be admitted as emergencies and has ordinary inpatient admissions and less likely to be admitted as day cases. Adjusted odds of ordinary admissions from the most deprived tenth occurring as emergencies (relative to admissions from the most affluent tenth) were 2.29 (95% confidence interval 2.09 to 2.52) for colorectal cancer, 2.20 (1.99 to 2.43) for lung cancer, and 2.41 (2.17 to 2.67) for female breast cancer; adjusted odds of admissions as day cases were 0.70 (0.64 to 0.76), 0.50 (0.44 to 0.56), and 0.56 (0.50 to 0. 62), respectively. Patients from deprived areas with lung or breast cancers were less likely to be recorded as having surgical interventions. Adjusted odds of patients from the most deprived tenth receiving surgery were 0.88 (0.78 to 1.00), 0.58 (0.48 to 0. 70), and 0.63 (0.56 to 0.71), respectively. Admissions for colorectal cancer from the most deprived areas were less likely to be to hospitals admitting 100 or more new patients a year; the opposite held true for breast cancer admissions. No association was found for lung cancer admissions.Earlier diagnostic and referral procedures in primary care in deprived areas are required if there are to be significant reductions in mortality from these cancers. A national information strategy is required to ensure the continued availability of population based data on NHS patients and to mandate standardised datasets from the private sector. Rationalisation of acute services, hospital mergers, and plans for bed closures must take into account the increased healthcare needs and inequities in access to treatment and care of residents in areas with high levels of deprivation. Health authorities and primary care groups should re-examine their purchasing intentions, service reviews, and monitoring arrangements in the light of these findings.
Rheumatoid Arthritis: Its Varied Clinical Manifestations
Authors: Marian W. Ropes, Walter Bauer
Journal: New England Journal of Medicine (1945)

ONE of the greatest difficulties in recognizing rheumatoid arthritis, except in a severe, advanced form, arises from the fact that the disease may have many types of onset and may vary greatly in its course.1 2 3 4 5 6 It often resembles other types of joint disease so closely that incorrect diagnoses are made and proper therapy is not instituted at a time when it is most beneficial.The typical picture of rheumatoid arthritis is well known in its fully developed form.1 2 3 4 5 6 7 8 9 Unfortunately, it is the severe, crippling stage that most physicians and patients visualize when the word "arthritis" is mentioned. Even in these . . .
Secondary genetic factors in cystic fibrosis lung disease
Authors: R. MAHADEVA
Journal: Thorax (2000)

Cystic fibrosis (CF) is the most common autosomal recessive genetic disorder amongst populations of northern European descent. Cloning of the cystic fibrosis transmembrane regulator (CFTR) gene in 19891 has allowed the assessment of clinical phenotype in patients with a specific genetic abnormality. Genotype/phenotype analysis showed a good correlation between the common CF mutation (deletion of phenylalanine at position 508 in the CFTR gene) and pancreatic insufficiency. This correlation does not hold for pulmonary disease which can vary markedly between patients with the same ΔF508 CFTR mutation.2 Many explanations have been advanced to account for this finding. Pulmonary disease is influenced by environmental factors such as the patient's age, pancreatic status, treatment regime, social class, smoking history, nutritional status, and colonisation with strains of Pseudomonas aeruginosa or Burkholderia cepacia .3-8 Moreover, …
Pain Control After Umbilical Hernia Repair
Authors: Brad W. Warner
Journal: JAMA Surgery (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Audit shows problems in Scotland's intensive psychiatric service
Authors: B. Christie
Journal: BMJ (2010)

An audit of intensive psychiatric units in Scotland has made a series of recommendations on improving the service. It found that although the 14 units generally provide well structured and compassionate care, several issues need to be addressed.

In particular, care may be compromised because of the mix of patients, which can include male sex offenders being looked after on the same unit as women and vulnerable young people. Some female patients said they felt uncomfortable in the predominantly male environment.

Intensive psychiatric units …
Doctors' attitudes resemble those of the old aristocracy
Authors: J. Watine
Journal: BMJ (2000)

NHS Direct Doctors may gain time to use their true skills if people start using NHS DirectEditor-O'Cathain et al's paper confirming that advice offered by nurses through NHS Direct was useful to callers 1 should make us question the generally hostile opinions on this service propounded in free publications that derive their income from pharmaceutical advertising. 2elephone advice can form an important part of an NHS that needs to meet people's concerns, even if some of these concerns seem trivial to doctors working under pressure.The primary end point of NHS Direct should be whether it meets the needs of its callers for information not whether it reduces work for any sector of the medical profession.If an increasingly information hungry population cannot get information from the NHS it will turn to other sources, which may be less reliable or relevant.Too often, medical staff see their role as tough gatekeepers of the NHS, excluding a public that would demand too much.This demeans the public and those working in the front line of the NHS.If the NHS develops several different front doors doctors may be freed to use their skills without waging a continual battle to persuade members of the public that they do not need further investigation, treatment, or referral.
Localized argyria caused by silver earrings
Authors: M.I. White
Journal: British Journal of Dermatology (1997)

Journal Article Localized argyria caused by silver earrings Get access M.I. White M.I. White Department of Dermatology, Aberdeen Royal Hospitals NHS Trust, Foresterhill, abnormal liver function tests. Aberdeen AB25 2ZN, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 136, Issue 6, 1 June 1997, Page 980, https://doi.org/10.1111/j.1365-2133.1997.tb03959.x Published: 01 June 1997
Synthesis and properties of amphiphilic networks 3: preparation and characterization of block conetworks of poly(butyl methacrylate-block-(2,3 propandiol-1-methacrylate-stat-ethandiol dimethacrylate))
Authors: S. Rimmer, M.J. German, J. Maughan, Y. Sun, N. Fullwood, J. Ebdon, S. MacNeil
Journal: Biomaterials (2004)
Sport and politics
Authors: J. Smith
Journal: BMJ (2010)

Richard Budgett has a challenging job. Not only does he have to run medical services for the athletes attending the Olympic and Paralympic Games in London in 2012; he’s also trying to stop the athletes from using illicit performance enhancing drugs; and he, along with others, has to build a legacy of improved health for the UK population after the games.

In his interview with Rebecca Coombes (doi:10.1136/bmj.c2904), Budgett, a former Olympic rower (gold medal in 1984) and sports medicine specialist, talks with enthusiasm of the facilities to be provided for the athletes and spectators: a polyclinic with sports medicine facilities, imaging, a pharmacy, an accident and emergency unit, and general practices, which will be handed over to the NHS …
Clinically Node-Negative Breast Cancer, Internal Mammary Lymph Nodes, and Sentinel Lymph Node Biopsy
Authors: Stuart C. Ramsay, Nathan Cassidy, Sally Meade
Journal: Clinical Nuclear Medicine (2008)

We report 2 cases demonstrating that localization of internal mammary (IM) sentinel lymph nodes with lymphoscintigraphy using peritumoral injection of Tc-99m antimony sulfide colloid, followed by resection using minimal access surgery, can reveal nodal metastatic disease in patients with clinically node-negative breast cancer when axillary sentinel nodes are not affected by metastatic disease. When this is found, it changes staging and can affect prognosis and treatment. These cases confirm that the technique used is sampling true sentinel IM nodes, that is nodes that receive direct lymph flow from the breast cancer, and confirm the importance of sampling IM sentinel lymph nodes. Unless techniques are used that are specifically designed to identify IM node drainage from the breast cancer site itself, with subsequent directed surgical removal of sentinel IM nodes, some patients with breast cancer will not be staged correctly.
A New Process for the Estimation of Uric Acid
Authors: E. A. Cook
Journal: BMJ (1882)

CASE II.-On May I8th of last year, I was consulted by a lady of about seventy years.She came panting into my room, with livid lips, dilated nostrils, and a bumping heart.There was evidence of an obstruc- tion of the liver, with some stomach-derangement, and scanty urine, con- taining urates, but non-albuminous.There had been for a month aedema of the right leg.There was mitral disease (said to be hereditary), rapid cardiac action, pulse go, palpitation, intermission, and a short dry cough.Undoubtedly the heart was primarily at fault; but its condition was