tbuckley/cabot-search huggingface dataset:
FRI0551 Characteristics of gout patients cared for by rheumatologists – results from the corrona gout registry site survey
Authors: L. Harrold, J. Greenberg, K. Saunders, C. Karki, N. Kifayeh, J. Kremer
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Gout is the most common inflammatory arthritis in the US with the majority of patients cared for by primary care providers. Little is known regarding the patients seen in rheumatology practices and the care they receive. <h3>Objectives</h3> To ascertain treatment patterns and to characterize gout patients under the care of Rheumatologists. <h3>Methods</h3> All sites (N=121) participating in the Consortium of Rheumatology Researchers of North America Inc. (CORRONA), a US nationwide observational rheumatic disease registry, were contacted including 143 rheumatologists. Rheumatologists were asked questions regarding gout patient characteristics, treatment patterns and outcomes. <h3>Results</h3> Seventy rheumatologists (49%) completed the self-administered questionnaires. Treatment patterns are presented in Table 1. Even after resolution of the acute gouty symptoms, 80% of rheumatologists reported staying involved in the chronic care of their patients. Most rheumatologists (70%) reported seeing 1-5 active gout patients a month and 75% stated they cared for 1-10 asymptomatic chronic gout patients monthly. Half of rheumatologists reported that their typical gout patient had between 0-1 flares per year, while a similar proportion (49%) reported between 2-4 per year. Similarly about half stated that &lt;10% of their patients have recurrent gout flares yearly with another 49% stating the proportion is 10-25% of patients. The vast majority of providers estimated that up to 25% of their patients have tophi. The majority of respondents (77%) indicated that &gt; 50% of their gout patients have achieved target serum urate levels of &lt;6 mg/dl; furthermore, the majority of respondents (71%) indicated that &gt;50% of their gout patients with flares are able to become flare-free with treatment within one year. The proportion of patients in their practice with chronic gout refractory to conventional therapy was estimated to be up to 10% by most rheumatologists. <h3>Image/graph</h3> <h3>Conclusions</h3> Rheumatologists report being engaged in caring for both active and asymptomatic patients and are actively involved in chronic gout disease management using the recommended treatment approaches. <h3>Acknowledgements</h3> Funding for this study was provided by CORRONA (study sponsor), from a development and subscription agreement/contract with Savient. <h3>Disclosure of Interest</h3> L. Harrold Grant/research support from: National Institute of Health - K23AR053856, Consultant for: CORRONA Inc., J. Greenberg Shareholder of: CORRONA Inc., Consultant for: Astra Zeneca, CORRONA Inc., Novartis, Pfizer, K. Saunders Employee of: CORRONA Inc., C. Karki Employee of: CORRONA Inc., N. Kifayeh Employee of: CORRONA Inc., J. Kremer Shareholder of: CORRONA Inc., Employee of: CORRONA Inc.
Aspirin in In-Flight Emergencies
Authors: Victor S. Sloan
Journal: Annals of Internal Medicine (1998)

Letters15 February 1998Aspirin in In-Flight EmergenciesVictor S. Sloan, MDVictor S. Sloan, MDUniversity of Medicine and Dentistry of New Jersey; New Brunswick, NJ 08903Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-4-199802150-00038 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The recent report by Saketkhou and colleagues [1] on the underuse of aspirin as the first therapy for patients admitted with a myocardial infarction reminds me of an experience I had on a flight from Chicago to New York several years ago. An elderly woman developed chest pain, apparently of cardiac nature, somewhere over western Ontario. On opening the medical kit, I was dismayed to find no aspirin. I later learned that the kit mandated by the Federal Aviation Administration for domestic carriers contains only 50% dextrose, epinephrine, diphenhydramine, nitroglycerin, a blood pressure cuff, stethoscope, syringes, needles, ...References1. Saketkhou BB, Conte FJ, Noris M, Tilkemeier P, Miller G, Forman DE, et al. Emergency department use of aspirin in patients with possible acute myocardial infarction. Ann Intern Med. 1997; 127:126-9. Google Scholar2. Jagoda A, Pietrzak M. Medical emergencies in commercial air travel. Emerg Med Clin North Am. 1997; 15:251-60. Google Scholar3. Cottrell JJ, Callaghan JT, Kohn GM, Hensler EC, Rogers RM. In-flight medical emergencies. One year of experience with the enhanced medical kit. JAMA. 1989; 262:1653-6. Google Scholar4. Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Lancet. 1988; 2:349-60. Google Scholar5. Gunnar RM, Bourdillon PD, Dison DW, Fuster F, Karp RB, Kennedy JW, et al. Guidelines for the early management of patients with acute myocardial infarction. A Report of the American College of Cardiology/American Heart Association Task Force Assessment of Diagnostic and Therapeutic Procedures (a subcommittee to develop guidelines for the early management of patients with myocardial infarction). Circulation. 1990; 82:664-707. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Medicine and Dentistry of New Jersey; New Brunswick, NJ 08903 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1998Volume 128, Issue 4Page: 326KeywordsAcute coronary syndromeAspirinBlood pressureElderlyEpinephrineGlucoseIschemiaMyocardial infarction Issue Published: 15 February 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
CD45 tyrosine phosphatase inhibits erythroid differentiation of umbilical cord blood CD34+ cells associated with selective inactivation of Lyn
Authors: Akira Harashima, Motoyuki Suzuki, Ayumi Okochi, Mayuko Yamamoto, Yoshinobu Matsuo, Ryuichi Motoda, Tamotsu Yoshioka, Kunzo Orita
Journal: Blood (2002)
Liver and Biliary Diseases
Authors: Frank L. Iber
Journal: JAMA (1996)

<b>Hepatology: A Textbook of Liver Disease</b>, vols 1 &amp; 2, edited by David Zakim and Thomas D. Boyer, 3rd ed, 1917 pp, with illus, $295, ISBN 0-7216-4836-3, Philadelphia, Pa, WB Saunders Co, 1996. The second edition of the popular<i>Liver and Biliary Diseases</i>appears 4 years after the first, reflecting the rapid changes, particularly in pathophysiology. This book has three impressive features setting it apart from other liver texts written for clinicians. The basic science and molecular concepts are better presented, there are excellent cartoons integrating many concepts and interrelations into a memorable diagram, and there is a carefully chosen, very limited, annotated bibliography; it is a strong feature, and the annotations guide one to the classics for further study. The 769 text pages are partitioned into 206 on structure and pathophysiology, 100 on complications of liver disease and management, 102 on the common liver diseases, 96 on
Carcinogens and Anticarcinogens in the Human Diet
Authors: S. Bingham
Journal: BMJ (1996)

Committee on Comparative Toxicity of Naturally Occurring Carcinogens National Academy Press, £36.95, pp 417 ISBN 0 309 05391 9

In our quest for essential nutrients, we are often unaware of the enormous numbers of other chemical constituents of food. In plants used for food alone at least 12 200 natural chemicals have been identified and the actual number is far greater. They include colours and flavours as insect attractants, and many are produced by the plant as defence against predators. Having limited excretory systems, plants accumulate variable amounts of these compounds, so that predicting human intake in epidemiological studies becomes a difficult exercise.

Nevertheless, many …
Mechanism of Beneficial Effects of Restrictive Mitral Annuloplasty in Patients With Dilated Cardiomyopathy and Functional Mitral Regurgitation
Authors: Koji Takeda, Kazuhiro Taniguchi, Yasuhiro Shudo, Satoshi Kainuma, Seiki Hamada, Hajime Matsue, Goro Matsumiya, Yoshiki Sawa
Journal: Circulation (2010)

Restrictive mitral annuloplasty (RMA) often leads to reverse left ventricular (LV) remodeling in patients with advanced cardiomyopathy and functional mitral regurgitation. However, the mechanism responsible for its favorable effects on LV ejection performance has been poorly understood. We evaluated systolic wall stress using cineangiographic multidetector computed tomography (MDCT) and our developed software system to assess stress-shortening relations before and after RMA.Twenty-four patients with dilated cardiomyopathy underwent 64-row MDCT before and 2 months after RMA. All patients underwent stringent downsizing annuloplasty with a semirigid complete ring. Reconstructed images were used to calculate LV end-diastolic index (EDVI) and end-systolic volume index (ESVI), LV ejection fraction, and regional and global end-systolic wall stress (ESS). After RMA, LVEDVI and LVESVI decreased from 151±52 to 131±53 mL/m(2) (P=0.0001) and from 114±48 to 92±50 mL/m(2) (P=0.0001), respectively. Global ESS decreased from 157±43 to 139±50 kdyne/cm(2) (P=0.01), and LV ejection fraction improved from 27±8.0 to 33±13% (P=0.0007). There were significant correlations between change in LVEDVI and LVESVI (r=0.88, P<0.0001) and change in LVESVI and global ESS (r=0.68, P=0.0002). Moreover, the magnitude of increase in LV ejection fraction significantly correlated with the degree of reduction in global ESS (r=-0.61, P=0.002). Patients without significant reverse LV remodeling had significantly higher preoperative and postoperative global ESS than those with it.Our study suggests that decrease in afterload after reduction in volume overload was responsible for postoperative reverse LV remodeling process after RMA.
Preoperative prediction of the extrathyroidal extension of papillary thyroid carcinoma with ultrasonography versus MRI: A retrospective cohort study
Authors: Hana Kim, Jeong-Ah Kim, Eun Ju Son, Ji Hyun Youk, Tae-Sub Chung, Cheong Soo Park, Hang-Seok Chang
Journal: International Journal of Surgery (2014)
Hormone treatment increases breast cancer risk, study shows
Authors: S. Mayor
Journal: BMJ (2003)

Long term use of combined hormone replacement therapy (HRT) doubles the risk of breast cancer, according to a major epidemiological study published last week that showed for the first time the higher risk with combined oestrogen and progestogen treatment.



From 1996 to 2001 the million women study recruited 1 084 110 women in the United Kingdom aged 50-64 years. When they were invited to attend for routine mammography the women were asked to complete a questionnaire that included questions about their use of HRT. They were then …
Alcohol Consumption and Tissue-Type Plasminogen Activator
Authors: John N. Strand
Journal: JAMA (1995)

To the Editor.  —There are no data to indicate that physicians should recommend 30 mL (1 fl oz) of alcohol a day because no data were presented to prove that 30 mL of alcohol a day increases life span. 1 The comment in the accompanying Editorial 2 that 80 924 lives a year would be saved is based on the unsupported conjecture that the J-shaped alcohol mortality curve has a downward drop at 30 mL of alcohol a day. The article refers to two studies that show that acute alcohol intake reduces (not increases) t-PA activity. Physicians cannot recommend that the public take alcohol, which has such a narrow (or nonexistent) therapeutic range.  The beneficial effect of alcohol may be the protein malnutrition that is associated with increasing alcohol use. Table 1 of the article should have evaluated protein nutrition (perhaps by doing a serum albumin level correlation with t-PA)
Screening for small for dates fetuses
Authors: T Chard, R J Lilford
Journal: BMJ (1985)

Finally, it is perhaps worth restating that the screening programme in Britain, though falling short of its potential effectiveness, has almost certainly not failed so completely as is sometimes assumed.There is no reasonable doubt that there has been a substantial increase in the incidence of carcinoma in situ and invasive cancer among younger women and this increase has probably been held in check as a result of screening.
Heart failure and breast enlargement suggesting cancer.
Authors: G McElligott, M G Harrington
Journal: BMJ (1986)

1986 (figure). Capillary loops were not thickened and no trichrome positive deposits were seen.The tubules, interstitium, and blood vessels were all normal.Immunofluorescence studies were negative for all immunoglobulins, fibrin, and g-IC.Electron microscopy showed diffuse foot process fusion of the podocytes (see figure) with no electron dense deposits.The basement membrane was normal.He received corticosteroids, and his oedema decreased dramatically in two weeks.He again defaulted follow up.
FGF-2 Disrupts Mitotic Stability in Prostate Cancer through the Intracellular Trafficking Protein CEP57
Authors: Rolando Cuevas, Nina Korzeniewski, Yanis Tolstov, Markus Hohenfellner, Stefan Duensing
Journal: Cancer Research (2012)

Abstract Malignant tumors with deregulated FGF-2 expression such as prostate cancer are also frequently aneuploid. Aneuploidy can be caused by cell division errors due to extra centrosomes and mitotic spindle poles. However, a link between FGF-2 overexpression and chromosome missegregation has so far been elusive. Here, we show that FGF-2 rapidly uncouples centrosome duplication from the cell division cycle in prostate cancer cells through CEP57, an intracellular FGF-2–binding and trafficking factor. CEP57 was initially identified as a regulator of centriole overduplication in an RNA interference screen. We subsequently found that CEP57 rapidly stimulates centriole overduplication and mitotic defects when overexpressed and is required not only for FGF-2–induced centriole overduplication but also for normal centriole duplication. We provide evidence that CEP57 functions by modulating tubulin acetylation, thereby promoting daughter centriole stability. CEP57 was found to be overexpressed on the mRNA and protein level in a subset of prostate cancers, of which the vast majority also showed FGF-2 upregulation. Taken together, our results show an unexpected link between altered microenvironmental signaling cues such as FGF-2 overexpression and mitotic instability and provide a rationale for the therapeutic targeting of the FGF-2/FGFR1/CEP57 axis in prostate cancer. Cancer Res; 73(4); 1400–10. ©2012 AACR.
Facial palsy as first presentation of acute myeloid leukemia
Authors: Bhrigu Raj Sood, Brij Sharma, Satish Kumar, Dalip Gupta, Ashok Sharma
Journal: American Journal of Hematology (2003)

Abstract Granulocytic sarcoma or chloroma is a tumor composed of myeloblast or monoblast. These tumors may be found in any location of the body and occur in 5% of acute myeloid leukemia (AML) cases and are more common in pediatric patients. In this report we describe the case of a 27‐year‐old male who developed lower motor neuron seventh nerve palsy followed by swelling of the parotid gland. Fine‐needle aspiration cytology (FNAC) of the soft tissue swelling revealed scattered blasts, and peripheral smear and bone marrow aspirate examination suggested AML. This is a rare presentation of a granulocytic sarcoma leading to a diagnosis of AML. Am. J. Hematol. 74:200–201, 2003. © 2003 Wiley‐Liss, Inc.
The Pathology of the Human Placenta
Authors: George D. Wilbanks
Journal: JAMA (1975)

The reprinting of Benirschke and Driscoll's classic work on the placenta makes available to current readers this excellent review of the placental literature and their extensive experience in placental pathology. It should be noted that this is not a new edition, but simply a reprinting of the 1967 publication. One can only echo the praise of those who reviewed the book in 1967-1968. After a short description of how to examine the placenta, the authors describe its normal morphology, the membranes, the vasculature, and vestigial remnants of the embryo. The section on multiple pregnancy is superb. The sections on abnormalities or diseases of the placenta include descriptions of cellular exchange between mother and fetus, circulatory disturbances, intervillus thrombosis and infarction, cysts, hemolytic disease of the newborn, abortion, hydatidiform mole, and tumors of the placenta. The presentation of infections describes well the state of affairs in 1965, but lacks new data,
Editorial: Message from China
Authors: R. H. Moser
Journal: JAMA (1974)

In this issue ofThe Journal(p 1527), Tavassoli, a young hematologist from the University of Tehran, presently at Scripps Clinic and Research Foundation in La Jolla, stresses the curious failure of the governments of many "developing countries" to come to grips with the grim medical realities existing right within their own borders. He finds this deficiency to be especially prominent in the area of medical education. Efforts to emulate Western medicine have resulted, not unpredictably, in "specialty orientation," which, he notes, is totally inappropriate to the needs of the mother country. Further, the young physicians themselves, who are "overtrained," without incentive or facilities to utilize their newly acquired talents, and without the skills or disposition to tackle the enormous practical problems at home, become disillusioned and discontented, and eventually defect to whence they were trained—the West. Yet, in many dark regions of the world, survival, not
Boost to NHS information systems as NHS signs Microsoft deal
Authors: D. Carnall
Journal: BMJ (2001)

The NHS continues to underinvest in information technology, the health secretary, Alan Milburn, acknowledged last week, as he announced that additional funding of £85m ($119m) a year was to be ringfenced for such projects, starting in April 2002.

Speaking at a conference for NHS chief executives, sponsored by Microsoft jointly with the Department of Health, Mr Milburn admitted, “I should have earmarked funds last year, and it was a mistake not to.”

Also addressing the meeting was …
Alcohol marketing: grooming the next generation
Authors: G. Hastings, N. Sheron
Journal: BMJ (2013)

Children are more exposed than adults and need much stronger protection

If protecting children from harm is the hallmark of a civilised society, the United Kingdom is failing the test when it comes to alcohol marketing. A new analysis conducted by the RAND Corporation for the European Commission shows that British regulatory structures are so flawed that teenagers, far from being shielded from alcohol promotion, are more exposed to it than are adults.1 It shows, for example, that 10-15 year olds in the UK see 10% more alcohol advertising on TV than their parents do. Even more shocking, when it comes to the specific sector of alcopops, they see 50% more (figure⇓).



Incidence rate ratios of exposure of different age groups to television alcohol advertising compared with adults in the United Kingdom1



Furthermore, digital advances are set to make things even worse. Although television is still the alcohol marketer’s principal channel of choice, it is rapidly being overtaken by new types of media, especially campaigns that harness social networking sites such as Facebook and Twitter. This sector is …
Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity
Authors: Ilirjana Bajrami, Jessica R. Frankum, Asha Konde, Rowan E. Miller, Farah L. Rehman, Rachel Brough, James Campbell, David Sims, Rumana Rafiq, Sean Hooper, Lina Chen, Iwanka Kozarewa, Ioannis Assiotis, Kerry Fenwick, Rachael Natrajan, Christopher J. Lord, Alan Ashworth
Journal: Cancer Research (2013)

Small-molecule inhibitors of PARP1/2, such as olaparib, have been proposed to serve as a synthetic lethal therapy for cancers that harbor BRCA1 or BRCA2 mutations. Indeed, in clinical trials, PARP1/2 inhibitors elicit sustained antitumor responses in patients with germline BRCA gene mutations. In hypothesizing that additional genetic determinants might direct use of these drugs, we conducted a genome-wide synthetic lethal screen for candidate olaparib sensitivity genes. In support of this hypothesis, the set of identified genes included known determinants of olaparib sensitivity, such as BRCA1, RAD51, and Fanconi's anemia susceptibility genes. In addition, the set included genes implicated in established networks of DNA repair, DNA cohesion, and chromatin remodeling, none of which were known previously to confer sensitivity to PARP1/2 inhibition. Notably, integration of the list of candidate sensitivity genes with data from tumor DNA sequencing studies identified CDK12 deficiency as a clinically relevant biomarker of PARP1/2 inhibitor sensitivity. In models of high-grade serous ovarian cancer (HGS-OVCa), CDK12 attenuation was sufficient to confer sensitivity to PARP1/2 inhibition, suppression of DNA repair via homologous recombination, and reduced expression of BRCA1. As one of only nine genes known to be significantly mutated in HGS-OVCa, CDK12 has properties that should confirm interest in its use as a biomarker, particularly in ongoing clinical trials of PARP1/2 inhibitors and other agents that trigger replication fork arrest.
Prevention of Nocturnal Hypoglycemia Using Predictive Alarm Algorithms and Insulin Pump Suspension
Authors: Bruce Buckingham, H. Peter Chase, Eyal Dassau, Erin Cobry, Paula Clinton, Victoria Gage, Kimberly Caswell, John Wilkinson, Fraser Cameron, Hyunjin Lee, B. Wayne Bequette, Francis J. Doyle
Journal: Diabetes Care (2010)

OBJECTIVE The aim of this study was to develop a partial closed-loop system to safely prevent nocturnal hypoglycemia by suspending insulin delivery when hypoglycemia is predicted in type 1 diabetes. RESEARCH DESIGN AND METHODS Forty subjects with type 1 diabetes (age range 12–39 years) were studied overnight in the hospital. For the first 14 subjects, hypoglycemia (&amp;lt;60 mg/dl) was induced by gradually increasing the basal insulin infusion rate (without the use of pump shutoff algorithms). During the subsequent 26 patient studies, pump shutoff occurred when either three of five (n = 10) or two of five (n = 16) algorithms predicted hypoglycemia based on the glucose levels measured with the FreeStyle Navigator (Abbott Diabetes Care). RESULTS The standardized protocol induced hypoglycemia on 13 (93%) of the 14 nights. With use of a voting scheme that required three algorithms to trigger insulin pump suspension, nocturnal hypoglycemia was prevented during 6 (60%) of 10 nights. When the voting scheme was changed to require only two algorithms to predict hypoglycemia to trigger pump suspension, hypoglycemia was prevented during 12 (75%) of 16 nights. In the latter study, there were 25 predictions of hypoglycemia because some subjects had multiple hypoglycemic events during a night, and hypoglycemia was prevented for 84% of these events. CONCLUSIONS Using algorithms to shut off the insulin pump when hypoglycemia is predicted, it is possible to prevent hypoglycemia on 75% of nights (84% of events) when it would otherwise be predicted to occur.