tbuckley/cabot-search huggingface dataset:
The heat-shock protein-70–induced renoprotective effect is partially mediated by CD4 + CD25 + Foxp3 + regulatory T cells in ischemia/reperfusion-induced acute kidney injury
Authors: Myung-Gyu Kim, Eun Jung Cho, Jae Won Lee, Yoon Sook Ko, Hee Young Lee, Sang-Kyung Jo, Won Yong Cho, Hyoung Kyu Kim
Journal: Kidney International (2013)
Potassium reabsorption in the proximal tubule of the dog nephron.
Authors: J F Watson
Journal: Journal of Clinical Investigation (1966)

Previous micropuncture studies ( 1, 2) have demonstrated that potassium is extensively reab- sorbed in the proximal tubule under conditions in which the net excretion of potassium in th-e urine varies, supporting the hypothesis that major ad- justments in the rate of potassium excretion occur in distal parts of the nephron (3).To further evaluate the reabsorptive process in the dog neph- ron, fractional reabsorption of potassium from the proximal tubule was studied by micropuncture techniques during reductions in glomerular filtra- tion rate (GFR) produced by renal arterial con- striction, during proximal tubular inhibition of sodium reabsorption produced by isotonic saline in- fusion (4, 5), and during stimulation of potassium secretion by potassium loading and acetazolamide administration. MethodsMale and female mongrel dogs weighing between 9 and 18 kg were used as experimental animals.The dogs were anesthetized by the rapid injection of 200 mg of thiopental sodium administered intravenously as a 2.5% solution in distilled water; small additional doses were administered from time to time to maintain the desired level of anesthesia.Indwelling catheters were inserted into the ureters through a suprapubic midline incision.Polyethylene catheters were also inserted into the fore- leg veins and the femoral vein or artery for the adminis- tration of fluids and collection of blood.The left kidney (experimental) was exposed through a flank incision and prepared for micropuncture as previously reported (6).Methods of tubular fluid collection and identification were also similar to those previously reported (6).In all experiments, 15-minute urine collection periods for the determination of inulin and potassium clearances *
Increased Cardiometabolic Risk Factors and Inflammation in Adipose Tissue in Obese Subjects Classified as Metabolically Healthy. Diabetes Care 2014;37:2813–2821
Authors: Javier Gómez-Ambrosi, Victoria Catalán, Amaia Rodríguez, Patricia Andrada, Beatriz Ramírez, Patricia Ibáñez, Neus Vila, Sonia Romero, María A. Margall, María J. Gil, Rafael Moncada, Víctor Valentí, Camilo Silva, Javier Salvador, Gema Frühbeck
Journal: Diabetes Care (2014)
Circulating leukocyte adhesion molecules in stable asthma and nonobstructive chronic bronchitis
Authors: G. C. Riise, S. Larsson, O. Löwhagen, B. A. Andersson
Journal: Allergy (1995)

Leukocyte adhesion molecules have been associated with airway inflammatory diseases such as asthma and obstructive chronic bronchitis. Lately, it has become possible to measure circulating forms of cell adhesion molecules ‘cCAMs) in body fluids. Elevated serum levels have been found in acute asthma and in obstructive chronic bronchitis. We investigated whether the patterns of cICAM‐1, cVCAM‐1, and cE‐selectin could serve as markers for airway inflammation in stable asthma and stable nonobstructive chronic bronchitis. Small‐volume bronchial lavage ‘BL) and serum from 15 controls, 13 asthmatics without steroid inhalation therapy, 11 asthmatics with regular steroid inhalation therapy, and 10 smokers with chronic bronchitis were analyzed. We found cICAM‐1, cVCAM‐1, and cE‐selectin to be present in serum from patients with stable asthma and stable nonobstructive chronic bronchitis. Only cICAM‐1 was found in BL fluid. No differences were seen between the subject groups for either cCAM, but levels of ECP were increased in the non‐steroid‐treated asthmatic group. Subject atopy or smoking did not increase the cCAM levels. In conclusion, the degree of airway inflammation in stable nonobstructive chronic bronchitis and stable asthma does not appear to be well associated with circulating ICAM‐1, cVCAM‐1, and cE‐selectin.
A STATE MEDICAL SERVICE
Authors: A. Todd-White
Journal: BMJ (1912)

<h3>Abstract</h3> Mitochondria are the powerhouses of eukaryotic cells and the site of essential metabolic reactions. Their main purpose is to maintain the high ATP/ADP ratio that is required to fuel the countless biochemical reactions taking place in eukaryotic cells<sup>1</sup>. This high ATP/ADP ratio is maintained through oxidative phosphorylation (OXPHOS). Complex I or NADH:ubiquinone oxidoreductase is the main entry site for electrons into the mitochondrial respiratory chain and constitutes the largest of the respiratory complexes<sup>2</sup>. Its structure and composition varies across eukaryotes species. However, high resolution structures are available only for one group of eukaryotes, opisthokonts<sup>3–6</sup>. In plants, only biochemical studies were carried out, already hinting the peculiar composition of complex I in the green lineage. Here, we report several cryo-electron microscopy structures of the plant mitochondrial complex I at near-atomic resolution. We describe the structure and composition of the plant complex I including the plant-specific additional domain composed by carbonic anhydrase proteins. We show that the carbonic anhydrase is an heterotrimeric complex with only one conserved active site. This domain is crucial for the overall stability of complex I as well as a peculiar lipid complex composed cardiolipin and phosphatidylinositols. Moreover we also describe the structure of one of the plant-specific complex I assembly intermediate, lacking the whole P<sub>D</sub> module, in presence of the maturation factor GLDH. GLDH prevents the binding of the plant specific P1 protein, responsible for the linkage of the P<sub>P</sub> to the P<sub>D</sub> module. Finally, as the carbonic anhydrase domain is likely to be associated with complex I from numerous other known eukaryotes, we propose that our structure unveils an ancestral-like organization of mitochondrial complex I.
The fully human anti-CD30 antibody 5F11 activates NF-κB and sensitizes lymphoma cells to bortezomib-induced apoptosis
Authors: Boris Böll, Hinrich Hansen, Friederike Heuck, Katrin Reiners, Peter Borchmann, Achim Rothe, Andreas Engert, Elke Pogge von Strandmann
Journal: Blood (2005)
Abstract 5328: GIAB: Genome reference material development resources for clinical sequencing
Authors: Chunlin Xiao, Justin Zook, Shane Trask, Stephen Sherry
Journal: Cancer Research (2014)

Abstract Reference materials play important roles in validating performance of sequencing platforms and enabling regulations of clinical applications. Genome-in-a-Bottle (GIAB) project is a collaboration between NIST, FDA, NCBI, academic sequencing groups, sequencing technology developers, and clinical laboratories to develop analytical-grade reference genome materials and accompanying performance metrics for the development of regulations and professional standards for clinical sequencing. NCBI is serving as the Data Coordination Center (DCC) and repository for the raw sequencing reads, mapped alignments, genotypes, and other details for each sample on a dedicated FTP site (ftp://ftp-trace.ncbi.nih.gov/giab/ftp). Here we describe the processes of data generations and data submissions, and how the community can access the data. We are also developing a genome browser for data visualization. GIAB consortium plans to release data to the public on a regular basis. Citation Format: Chunlin Xiao, Justin Zook, Shane Trask, Stephen Sherry, the Genome-in-a-Bottle Consortium. GIAB: Genome reference material development resources for clinical sequencing. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5328. doi:10.1158/1538-7445.AM2014-5328
GPs need to keep abreast of genetics BMA chairman explains disillusionment with NHS No safe limits to alcohol consumption, warns BMA GPs get guidance on fundraising Accidents in hospital to be studied
Authors: L. Beecham
Journal: BMJ (1995)

# GPs need to keep abreast of genetics {#article-title-2}

A need for general practitioners and primary care teams to acquire greater knowledge of the “new genetics” was emphasised by Dr Kenneth Calman, the government's chief medical officer, in evidence last week to the Commons science and technology committee's inquiry into human genetics. He said that unless general practitioners understood genetics and how to take a good family history an abnormality could be missed.

Dr Calman said that the Department of Health was engaged in a long term programme of professional education to develop genetic services, backed by good quality counselling at the time when it is needed. Educational material had been circulated to family doctors and a new paper, a progress guide to genetics, would be sent out soon.

Dr Calman predicted “significant advances” over the next five to 10 years not only in gene therapy but in the understanding of the pathogenesis of disease and the ability to predict health. He said that the NHS had to be ready to meet developments as they occur and put them into practice for the benefit of the population.

# BMA chairman explains disillusionment with NHS {#article-title-3}

“Why do so many senior members of the profession crave early retirement, and so many juniors disappear so disconcertingly at the very threshold of a promising career? Why the unprecedented stress, the tragic suicides, the flight to other lands?”

The chairman of the BMA council, Dr Sandy Macara, posed these questions in his state of the nation address to the association's junior members forum in Belfast last weekend. He suggested that some of the answers could be found by comparing three of …
TV: Cot Death Mothers: The Witch Hunt
Authors: R. Wilson
Journal: BMJ (2003)

Rating: ![Graphic][1]</img>![Graphic][2]</img> BBC 2, 13 February at 9 50 pm This documentary by the journalist John Sweeney focused on the interface between medicine and the law when there are miscarriages of justice following infant deaths, as in the case of Sally Clark, freed last month from a life sentence after the appeal court quashed her murder convictions ( BMJ 2003;326:304). The programme claimed that cot death parents were subjected to a witch hunt, and then proceeded to set up its own witch hunt. "What were the causes?" became "who is responsible?" and then "we name the guilty!" It principally targeted the paediatrician Professor Sir Roy Meadow, who, as an expert witness at Sally Clark's trial, famously claimed that the chances of two cot deaths occurring in the same family were 1 in 73 million. … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif
The activation peptide cleft exposed by thrombin cleavage of FXIII-A2 contains a recognition site for the fibrinogen α chain
Authors: Kerrie A. Smith, Richard J. Pease, Craig A. Avery, Jane M. Brown, Penelope J. Adamson, Esther J. Cooke, Søs Neergaard-Petersen, Paul A. Cordell, Robert A. S. Ariëns, Colin W. G. Fishwick, Helen Philippou, Peter J. Grant
Journal: Blood (2013)
Two more cases of novel coronavirus are confirmed in UK
Authors: J. Wise
Journal: BMJ (2013)

A further two cases of novel coronavirus infection have been confirmed in the United Kingdom, bringing the global total to 11, with three cases diagnosed in the UK.

The Health Protection Agency said there is now strong evidence of transmission from patient to patient, although the risk of infection is still considered to be very low.

Coronaviruses are causes of the common cold but can also include more severe illness such as severe acute respiratory syndrome. The new strain was first identified in September 2012 in a patient who died from a severe respiratory infection in June 2012. So far the infection has resulted in three deaths in Saudi Arabia and two in Jordan.

In September last year the Health Protection Agency confirmed a case in the UK in a man from Qatar who had recently travelled …
Continuous Intravenous Infusion of Small Doses of Insulin in Treatment of Diabetic Ketoacidosis
Authors: P. F. Semple, C. White, W. G. Manderson
Journal: BMJ (1974)

Continuous intravenous infusion of small amounts of insulin has been used in the management of a series of patients with diabetic ketoacidosis. In 13 patients with a plasma glucose level on admission of 725 mg/100 ml (+/- 80 S.E. of mean) and an arterial pH of 7.07 +/- 0.05 a mean loading dose of 6.5 +/- 0.82 units of soluble insulin was administered intravenously, and thereafter a sustaining infusion of 6.5 +/- 0.82 U/hr was continued until ketosis was corrected and the plasma glucose fell below 300 mg/100 ml. The total insulin dose needed to achieve this was 39.2 +/- 6.6 units given over a 3 to 10-hour period. Plasma insulin was measured in patients who had not previously received insulin and the mean level at an infusion rate of 4 U/hr was 75.6 +/- 8.0 muU/ml. Plasma glucose fell at a regular rate of 101 +/- 11 mg/100 ml/hr, and ketosis improved in parallel. Plasma potassium was well maintained throughout treatment. This regimen of treatment was clinically effective and simple to follow.
The Effect of Exercise on Normal Splenic Volume Measured With SPECT
Authors: ANTON C. OTTO, D J RONA du TOIT, P HENDRIK PRETORIUS, MATTHEUS G. LOTTER, ANDRIES van ASWEGEN
Journal: Clinical Nuclear Medicine (1995)

In a study group of 20 healthy young men, splenic volume was determined with SPECT before and after exercise. A randomly chosen control group of 10 comparable men was studied similarly, but without exercise intervention. The mean splenic volume did not change significantly in the control group (i.e., from 292.9 ml to 282.1 ml [P=0.75]). The mean splenic volume decreased 60.1 ml from 279.4 to 219.3 ml (21.5%) in the study group and this was highly significant (P=0.01). Although exercise induced splenic autotransfusion is generally considered to be unimportant in humans, significant splenic contractility was observed with this technique. In the normal individual with a large spleen or with functional splenomegaly, the contractility response may become more important and can now be measured in a quick and easy manner.
Side effects of the pill.
Authors: E C Grant
Journal: BMJ (1973)

In response to a letter by Drs. D.M. and S.M. Hall calling loss of libido with oral contraceptive use only psychological, the author states it would seem that drugs which can produce an atrophic endometrium and a dry vagina might also cause loss or decrease of libido. The progestogenic low-estrogen compounds produce endometrial glands which have a high level of monoamine oxidase, particularly in the premenstrual phase. The author has found a correlation of depression and loss of libido with the endometrial monoamine oxidase activity. Estrogenic sequential regimens had a low incidence of depression and low monoamide oxidase activity. The Halls' data, with a much greater number of women under age 30, implies that oral contraceptives are not well tolerated by older women. Women under age 20 seem to be slower to have depression changes. Unmarried women may be more reluctant to admit to side effects because of their need for an efficient contraceptive. In the author's follow-up of 341 women, 40% noted mood changes and headaches on discontinuing oral contraceptives. Of 31 women stopping low-estrogen compounds 70% noted depressive mood changes.
"THE 'ALKALINE TIDE' IN URINE"
Authors: A. L. Benedict
Journal: JAMA (1922)

To the Editor:  —Referring to your editorial comment on the alkaline tide in urine (The Journal, October 7, p. 1248), from studies that involved the saving and titration of urine for a month, from quite a number of fractional examinations covering periods of a day or more in patients, and from a few thousand single tests of urines: there ain't no such thing.  This crude and possibly rude contradiction should be qualified. It is quite possible that cryoscopic methods and definitions may show the alkaline and acid tides commonly taught for a century or more, and it may even be that the assumption of such a tide by so many of the early clinicians may not have been merely an induction from physiologic theory but that differences in diet may account for discrepant observations. Quite frequently, I have observed, not an alkaline tide but a diminution in gross acidity, following
Asthma control, adiposity, and adipokines among inner-city adolescents
Authors: Meyer Kattan, Rajesh Kumar, Gordon R. Bloomberg, Herman E. Mitchell, Agustin Calatroni, Peter J. Gergen, Carolyn M. Kercsmar, Cynthia M. Visness, Elizabeth C. Matsui, Suzanne F. Steinbach, Stanley J. Szefler, Christine A. Sorkness, Wayne J. Morgan, Stephen J. Teach, Vanthaya N. Gan
Journal: Journal of Allergy and Clinical Immunology (2010)
Associations Between Outpatient Heart Failure Process-of-Care Measures and Mortality
Authors: Gregg C. Fonarow, Nancy M. Albert, Anne B. Curtis, Mihai Gheorghiade, J. Thomas Heywood, Yang Liu, Mandeep R. Mehra, Christopher M. O'Connor, Dwight Reynolds, Mary Norine Walsh, Clyde W. Yancy
Journal: Circulation (2011)

Assessment of the quality of care for outpatients with heart failure (HF) has focused on the development and use of process-based performance measures, with the supposition that these care process measures are associated with clinical outcomes. However, this association has not been evaluated for current and emerging outpatient HF measures.Performance on 7 HF process measures (4 current and 3 emerging) and 2 summary measures was assessed at baseline in patients from 167 US outpatient cardiology practices with patients prospectively followed up for 24 months. Participants included 15 177 patients with reduced left ventricular ejection fraction (≤35%) and chronic HF or post-myocardial infarction. Multivariable analyses were performed to assess the process-outcome relationship for each measure in eligible patients. Vital status was available for 11 621 patients. The mortality rate at 24 months was 22.1%. Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use, β-blocker use, anticoagulant therapy for atrial fibrillation, cardiac resynchronization therapy, implantable cardioverter-defibrillators, and HF education for eligible patients were each independently associated with improved 24-month survival, whereas aldosterone antagonist use was not. The all-or-none and composite care summary measures were also independently associated with improved survival. Each 10% improvement in composite care was associated with a 13% lower odds of 24-month mortality (adjusted odds ratio, 0.87; 95% confidence interval, 0.84 to 0.90; P<0.0001).Current and emerging outpatient HF process measures are positively associated with patient survival. These HF measures may be useful for assessing and improving HF care.http://www.clinicaltrials.gov. Unique identifier: NCT00303979.
Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor
Authors: Patrick P. Ng, Gustavo Helguera, Tracy R. Daniels, Simon Z. Lomas, Jose A. Rodriguez, Gary Schiller, Benjamin Bonavida, Sherie L. Morrison, Manuel L. Penichet
Journal: Blood (2006)
A CASE OF VERONAL POISONING
Authors: M. I. Dick
Journal: BMJ (1914)

tested as control by the Stas process yieldedl onily 4 mg. of iioln-crystalline ether extract.T'hle crystals were dissolved in alcolhol and a dlrop allowed to evaporate on a microscope slide.(Fig. 1.)A roughi quarter of a tabloid was then dissolved in 1 oz. of norimal urine, whlichi was ptit thirouglih the same process; 53 iig.were recovered and crystallized from alcolhol.(Fig. 2.) A single large crystal of veronal was also
Susceptibility of pediatric HIV-1 isolates to recombinant CD4-IgG2 (PRO 542) and humanized mAb to the chemokine receptor CCR5 (PRO 140)
Authors: William T. Shearer, Jaime G. DeVille, Pearl M. Samson, John H. Moye, Courtney V. Fletcher, Joseph A. Church, Hans M.L. Spiegel, Paul Palumbo, Terence Fenton, M. Elizabeth Smith, Bobbie Graham, Joyce M. Kraimer, William C. Olson
Journal: Journal of Allergy and Clinical Immunology (2006)
Meningitis in Whipple's disease.
Authors: D G Thompson, J M Ledingham, A J Howard, C L Brown
Journal: BMJ (1978)

Meningitis in Whipple's diseaseNeurological features are well recognised in Whipple's disease but clinical meningeal inflammation is rare.'We report a further case which was unaccompanied by any other clinical neurological abnor- mality. Case reportA 51-year-old Caucasian man was referred with a three-year history of increasing polyarthritis, fever, muscle weakness, and steatorrhoea partially responsive to prednisolone, 15 mg/day.Histologically the jejunal biopsy specimen was characteristic of Whipple's disease showing infiltration with on 15 July
<i>Trichosporon inkin</i>as an Emergent Pathogen in Patients With Severe Pemphigus
Authors: João Nobrega de Almeida Júnior, Renata Buccheri de Oliveira, Amaro Duarte, Adriana Lopes Motta, Flávia Rossi, Dulce Sachiko Yamamoto de Figueiredo, Gilda Maria Barbaro Del Negro, Valeria Aoki, Celina Wakisaka Maruta, Claudia Giuli Santi, Gil Benard
Journal: JAMA Dermatology (2015)

reatment for pemphigus relies on systemic corticosteroids, usually administered with other immunosuppressant agents.Treatment controls disease activity but may lead to severe infections. 1 Mortality rates can reach 80% to 100% in patients with pemphigus who develop septicemia. 2,3richosporon inkin is the etiologic agent of white piedra, a benign disease of hair shafts. 4Invasive fungal infection caused by this species was described 4 in patients with predisposing factors, such as oncohematologic diseases and neutropenia.Recently, invasive fungal infection caused by T inkin was reported in patients in our hospital who underwent solid organ transplantation. 5Our aim is to report what we believe to be the first cases of deep-seated infections related to T inkin in patients with pemphigus.Positive blood cultures (obtained using Bactec Plus Aerobic/F; Becton Dickinson and Company) were platted (CHROMagar Candida; Becton Dickinson and Company), and phenotypic identification was carried out by urease test, slide culture, and the carbon assimilation panel (API 20AUX; bioMérieux).To confirm species identification, double-strand sequencing of the ribosomal DNA intergenic spacer 1 region was performed 6 ; sequences were then compared with those in the GenBank database (http://www.ncbi.nlm.nih.gov).Antifungal susceptibility testing for amphotericin B, fluconazole, itraconazole, and voriconazole was carried out using the recently revised European Committee on Antimicrobial Susceptibility Testing microdilution method for yeasts.
What's the Relative Risk?
Authors: Jun Zhang, Kai F. Yu
Journal: JAMA (1998)

Logistic regression is used frequently in cohort studies and clinical trials. When the incidence of an outcome of interest is common in the study population (&gt;10%), the adjusted odds ratio derived from the logistic regression can no longer approximate the risk ratio. The more frequent the outcome, the more the odds ratio overestimates the risk ratio when it is more than 1 or underestimates it when it is less than 1. We propose a simple method to approximate a risk ratio from the adjusted odds ratio and derive an estimate of an association or treatment effect that better represents the true relative risk.