tbuckley/cabot-search huggingface dataset:
Antidepressant Use in Patients Prescribed β-Blockers-Reply
Authors: Jerry Avorn
Journal: JAMA (1986)

In Reply.—  In general, we agree with the concerns expressed in several of the letters that our findings indicating a higher frequency of treatment for depression in patients taking β-blockers is an initial cross-sectional study that, as we noted in several places in the article, will need to be further documented in subsequent investigations before it can be considered proved. However, several specific comments require further discussion. The rare occurrence of migraine in the population studied ( decrease in pharmacodynamic effect, owing to diminished receptor sensitivity to these drugs with advancing age. 1 We concur with Dr Stone
Prevention and Treatment of Pressure Ulcers-Reply
Authors: Virginia S. Cowart
Journal: JAMA (1987)

<h3>In Reply.—</h3> The brief news report from a meeting was not intended to be a comprehensive treatment of the subject of pressure ulcers and, thus, not all aspects were covered. With regard to Dr Curtin's comments: My original story did say that pressure ulcers occur beneath a bony prominence; however, as you note, that fact is well known and our senior editors did not think it needed to be repeated for physician-readers. As for the photographs and legends, I defer to Dr Silvetti, who provided both. He said the treatment you describe is standard but that there are also other approaches. The wound shown on page 593 was treated with a new biochemical approach<sup>1</sup>and healing did occur. The patient was sent home with an appropriate air cushion to prevent recurrence and has remained well for more than two years. With regard to Dr Gluck's comments: The Clinitron suspension
Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts
Authors: T Wieder, A Prokop, B Bagci, F Essmann, D Bernicke, K Schulze-Osthoff, B Dörken, H-G Schmalz, PT Daniel, G Henze
Journal: Leukemia (2001)
Surgeon who removed most of baby's bladder allowed to practise under conditions
Authors: C. Dyer
Journal: BMJ (2010)

A consultant paediatric surgeon who mistakenly removed 90% of a 7 week old baby girl’s bladder during a hernia operation has avoided being struck off the medical register. 

The General Medical Council found that Pierina Kapur’s fitness to practise was impaired because of her misconduct during and after the operation at Manchester Children’s Hospital, but it allowed her to continue to practise under conditions.

The GMC’s counsel, Catherine Cundy, told the fitness to practise panel that Miss Kapur’s removal of most of the …
Costs Associated With Health Care–Associated Infections in Cardiac Surgery
Authors: Giampaolo Greco, Wei Shi, Robert E Michler, David O Meltzer, Gorav Ailawadi, Samuel F Hohmann, Vinod H Thourani, Michael Argenziano, John H Alexander, Kathy Sankovic, Lopa Gupta, Eugene H Blackstone, Michael A Acker, Mark J Russo, Albert Lee, Sandra G Burks, Annetine C Gelijns, Emilia Bagiella, Alan J Moskowitz, Timothy J Gardner
Journal: Journal of the American College of Cardiology (2015)
Histiocytosis X–an immune deficiency disease? Studies on antibody-dependent monocyte-mediated cytotoxicity
Authors: KNUD KRAGBALLE, HUGH ZACHARIAE, TROELS HERLIN, JORGEN JENSEN
Journal: British Journal of Dermatology (1981)

Six children with histiocytosis X, all in clinical remission, were investigated for antibody‐dependent cytotoxicity mediated by monocytes and neutrophils. Monocytes demonstrated a reduced cytotoxicity and a normal Fc receptor activity. ludged by light microscopy the monocytes were normal. Preincubation with the patient's serum did not influence the cytotoxicity of normal monocytes. Neutrophils from patients with histiocytosis X showed a normal cytotoxic activity. We postulate a functional defect of the mononuclear phagocyte system in histiocytosis X.
Virtual Colonoscopy Accepted As Primary Colon Cancer Screening Test
Authors: Nancy J. Nelson
Journal: JNCI Journal of the National Cancer Institute (2008)

raphy, a colonoscopy was performed without the physician’s having knowledge of the CT colonography results. Colonoscopy results and the examination of the tissue removed during the procedure were used as the reference standard. A positive result for CT colonography was defi ned as a lesion of 5 mm or larger that was seen with both procedures and corroborated with a biopsy. The trial showed that the accuracy of CT colonography was similar to that of conventional colonoscopy. Ninety percent of the polyps seen by colonoscopy that were 10 mm or larger — the ones most likely to develop into cancer — were also detected with CT colonography. Intermediate-sized polyps, ranging from 6 – 9 mm, were detected by CT colonography with a sensitivity of 90% for 9-mm polyps, 87% for 8-mm polyps, 84% for 7-mm polyps, and 78% for 6-mm polyps. The procedure for CT colonography takes about 10 – 15 minutes. As the patient is lying down, a scanner takes a series of x-rays of the entire colon and rectum that are assembled by a computer into a 3-D image and reviewed by a radiologist. Unlike the conventional colonoscopy, in
The Purity of Cholestyramine Resin-Reply
Authors: Basil M. Rifkind
Journal: JAMA (1989)

In Reply.—  As pointed out in the original report of the Lipid Research Clinics Coronary Primary Prevention Trial results,1the total incidence of fatal and nonfatal malignant neoplasms was similar in the cholestyramine resin and placebo groups. These incidence rates were somewhat lower than overall US cancer rates for comparably aged men. However, when the many different categories of malignancies were examined, the combined incidence of cancers of the mouth, pharynx, gastrointestinal tract, and pancreas was somewhat greater (21 vs 11 cases) in the cholestyramine resin group than in the placebo group. This excess incidence of gastrointestinal tract cancers was offset by reduced incidence of other cancers, particularly of the lung and prostate. The small numbers and multiple categories precluded firm conclusions, although the observation of excess cancers in the organ system directly exposed to cholestyramine resin was a matter of concern, especially in view of animal experiments in
Abstract 4516: Targeted delivery of resveratrol to improve therapeutic outcome in prostate cancer.
Authors: Rajesh Singh, Pranav Gupta, Shailesh Singh, James W. Lillard
Journal: Cancer Research (2013)

Abstract Conventional chemotherapeutics offered to treat prostate cancer (PCa) are not selectively targeted and due to this fact they are toxic to the normal cells. Thus, it is imperative to identify new anti-cancer agents and/or methods to selectively target PCa cells without affecting normal cells. In this regard, resveratrol (trans-3, 5, 4’-trihydroxystilbene), a plant polyphenol, has shown very promising results. Despite the proven anti-tumor effects of resveratrol, clinical use of this compound is restricted due to its poor bioavailability. To surmount these problems, we developed nanoparticles, loaded with resveratrol, using a planetary-balled milling (PBM) technique and tagged them with folate for targeted delivery to PCa cells, which express high affinity folate receptors. Image Stream multispectral imaging was used to measure the response of resveratrol-loaded PBM nanoparticles, and free resveratrol on various PCa cell lines. Resveratrol-loaded folic acid-coated PBM nanoparticles selectively targeted PCa cells and induced apoptosis. Furthermore, our results indicate that targeted delivery of resveratrol using PBM nanoparticles was 70-85% more effective in killing PCa cells at concentrations lower than the IC50 of free resveratrol. Citation Format: Rajesh Singh, Pranav Gupta, Shailesh Singh, James W. Lillard. Targeted delivery of resveratrol to improve therapeutic outcome in prostate cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4516. doi:10.1158/1538-7445.AM2013-4516
EFFECT OF INTRAVENOUSLY INJECTED DEXTROSE ON THE RATE OF PROPULSION IN THE SMALL INTESTINE
Authors: J. P. Quigley
Journal: JAMA (1934)

When oral alimentation is inexpedient or impossible, the intravenous administration of dextrose is often desirable to supply nutrition and to prevent or relieve acidosis and the like. This situation is especially prone to occur in patients having actual or latent gastro-intestinal disturbances. Clinicians may hesitate in the employment of intravenous dextrose if they have reason to believe that this procedure has a tendency to cause ileus. In spite of the need for information regarding the action of intravenous dextrose on intestinal motility, investigations on this subject have been rare. In 1924, Bulatao and Carlson<sup>1</sup>reported that in dogs intravenous injections of 50 per cent dextrose caused an inhibition of gastric hunger contractions. This conclusion has frequently been extended by inference to other portions of the gut. The belief has thus become current that intravenous injections of dextrose inhibit the entire gastro-intestinal tract. This is in spite of the observation
Unusual breathing in a 7 year old
Authors: F. Abel, D. Kilner, S. Sonnappa
Journal: BMJ (2012)

A 7 year old girl was referred for a sleep study after her parents noticed unusual breathing while she slept. Her breathing was described as slow with many pauses. After a normal term delivery, she was diagnosed with truncus arteriosus associated with a large ventricular septal defect. Both were surgically repaired at age 1 month, with uneventful postoperative recovery and normal subsequent cardiac function. She had no overt dysmorphic features. She was nasogastrically fed from age 7 months for failure to thrive after feeding difficulties, then via a gastrostomy from age 2.5 years until 4 years. A clinical diagnosis of DiGeorge syndrome was confirmed by detection of a 22q11.2 deletion on genetic analysis. By age 6 years, she was fully orally fed and swallow assessment was normal. She remained clinically well until age 7 years, when the unusual breathing started. A history of choking on food and drinks, difficulty coping with oral secretions, and frequent drooling was elicited from her parents. Clinical examination was normal. A videofluoroscopic swallow assessment showed obvious aspiration. A cardiorespiratory sleep study was performed and the following summary was obtained (fig 1⇓). Fig 1 Cardiorespiratory sleep study
Primitive interleukin 3 null hematopoietic cells transduced with BCR-ABL show accelerated loss after culture of factor-independence in vitro and leukemogenic activity in vivo
Authors: Xiaoyan Jiang, Eddy Ng, Calvin Yip, Wolfgang Eisterer, Yves Chalandon, Matthew Stuible, Allen Eaves, Connie J. Eaves
Journal: Blood (2002)
Adolescent Emotional Development and the Emergence of Depressive Disorders
Authors: Mary G. Burke
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Delayed Puberty and Estrogen Resistance in a Woman with Estrogen Receptor α Variant
Authors: Samuel D. Quaynor, Earl W. Stradtman, Hyung-Goo Kim, Yiping Shen, Lynn P. Chorich, Derek A. Schreihofer, Lawrence C. Layman
Journal: New England Journal of Medicine (2013)

Although androgen resistance has been characterized in men with a normal chromosome complement and mutations in the androgen-receptor gene, a mutation in the gene encoding estrogen receptor α (ESR1) was previously described only in one man and not, to our knowledge, in a woman. We now describe an 18-year-old woman without breast development and with markedly elevated serum levels of estrogens and bilateral multicystic ovaries. She was found to have a homozygous loss-of-function ESR1 mutation in a completely conserved residue that interferes with estrogen signaling. Her clinical presentation was similar to that in the mouse orthologue knockout. This case shows that disruption of ESR1 causes profound estrogen resistance in women. (Funded by the National Institutes of Health.).
Acute respiratory obstruction caused by ingestion of a caustic substance.
Authors: D C Williams
Journal: BMJ (1985)

Accident provoque chez un nourrisson de 7 mois par l'ingestion d'un comprime de desinfectant (utilise pour la sterilisation de biberons). Vomissements et detresse respiratoire necessitant des soins intensifs, intubation, tracheostomie et alimentation par sonde
Dual Isotope Parathyroid Imaging
Authors: MARK M. MASLACK, ROBERT J. BROSBE
Journal: Clinical Nuclear Medicine (1986)

Eleven patients who had clinical and biochemical evidence of primary hyperparathyroidism were studied using dual isotope technetium-thallium parathyroid subtraction imaging. The parathyroid scans correctly identified all surgically proven parathyroid adenomas. Three abnormal foci also were identified that were not parathyroid adenomas. These were caused by adenocarcinoma metastatic to a lymph node, primary papillary carcinoma of the thyroid, and parathyroid hyperplasia. This report also demonstrates the importance of surgically examining all abnormal sites of uptake.
Reactions of the Normal and Abnormal Heart to Motorcar Driving.
Authors: Walter Somerville
Journal: Annals of Internal Medicine (1968)

s1 May 1968Reactions of the Normal and Abnormal Heart to Motorcar Driving.Walter Somerville, F.R.C.P., P. I. Taggart, M.R.C.P., D. GibbonsWalter Somerville, F.R.C.P.Search for more papers by this author, P. I. Taggart, M.R.C.P.Search for more papers by this author, D. GibbonsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1162_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe object was to observe the reaction of certain cardiac functions to motorcar driving. This report related to the electrocardiogram (EKG) and the heart rate.Radio electrocardiograms were recorded before, during, and after driving in busy city traffic. The test subjects were persons with normal hearts, coronary heart disease, and various arrhythmias. Additional observations were made on professional drivers during competitive racing. Heart rates of 120 to 140 were common in all groups, usually unknown to the subject. Sinus tachycardia of 180 was recorded during racing. Nonspecific, reversible ST and T changes appeared in certain normals. Ischemic ST and T... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Walter Somerville, F.R.C.P.; P. I. Taggart, M.R.C.P.; D. GibbonsAffiliations: London, PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1162-1162KeywordsArrhythmiaCoronary heart diseaseElectrocardiographyHeartHeart rateTachycardia ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...
Use and Yield of Endoscopy in Patients With Uncomplicated Gastroesophageal Reflux Disorder
Authors: Jennifer R. Kramer, Mohammad H. Shakhatreh, Aanand D. Naik, Zhigang Duan, Hashem B. El-Serag
Journal: JAMA Internal Medicine (2014)

Practice guidelines recommend esophagogastroduodenoscopy (EGD) screening for Barrett esophagus (BE) or esophageal cancer for patients with uncomplicated gastroesophageal reflux disease (GERD), especially in high-risk patients (symptoms for >5 years, white race, male sex, age >50 years, and family history of BE or esophageal cancer).1,2 However, the extent of using screening EGD, its predictors, and diagnostic yield are unclear. We aimed to determine prevalence, predictors, and yield of screening EGD in a large national sample of patients with uncomplicated GERD.
Endotracheal intubation: friend or foe?
Authors: G B Smith
Journal: BMJ (1986)

thing from the Biko affair" and in relation to treatment of injuries received during civil unrest whether "the deafening silence of South African doctors means that once again they are prepared to condone the excesses of the South African state."His concern about the treatment of people injured during civil unrest is shared by many health professionals in South Africa.It would not be fair or appropriate to leave the impression that concern about this, and other issues relevant to the delivery of equitable and ethical medical care, has not been strongly voiced by doctors and medical faculties dedicated to providing medical care of the highest ethical standard despite restrictions im- posed by abhorrent discriminatory policies.
Matrix metalloproteinase 8 contributes to solubilization of IL-13 receptor α2 in vivo
Authors: Weiguo Chen, Yasuhiro Tabata, Aaron M. Gibson, Michael O. Daines, Manoj R. Warrier, Marsha Wills-Karp, Gurjit K. Khurana Hershey
Journal: Journal of Allergy and Clinical Immunology (2008)
Application of neural networks in structure-activity relationships
Authors: Istv�n K�vesdi, Maria Felisa Dominguez-Rodriguez, L�szl� �rfi, G�bor N�ray-Szab�, Andr�s Varr�, Julius Gy. Papp, P�ter M�tyus
Journal: Medicinal Research Reviews (1999)

Methodology and application of artificial neural networks in structure–activity relationships are reviewed focusing on the most frequently used three-layer feedforward back-propagation procedure. Two applications of neural networks are presented and a comparison of the performance with those of CoMFA and a classical QSAR analysis is also discussed. © 1999 John Wiley & Sons, Inc. Med Res Rev, 19, No. 3, 249–269, 1999.
914 HBsAg CLEARENCE AFTER LONG-TERM FOLLOW-UP IN CHRONIC HEPATITIS B PATIENTS TREATED WITH INTERFERON ALPHA AND NUCLEOS(T)IDE ANALOGUES
Authors: B. Pinarbasi, S. Kaymakoglu, F. Akyuz, H. Issever, F. Ermis, A. Uyanikoglu, B. Baran, F. Hindilerden, A. Sumnu, K. Demir, F. Besisik, Y. Cakaloglu, Z. Mungan, A. Okten
Journal: Journal of Hepatology (2009)
NOTES ON SOME OINTMENT BASES.
Authors: GODFREY BAMBER
Journal: British Journal of Dermatology (1940)

Journal Article NOTES ON SOME OINTMENT BASES. Get access GODFREY BAMBER GODFREY BAMBER Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 52, Issue 1, 1 January 1940, Pages 21–25, https://doi.org/10.1111/j.1365-2133.1940.tb09892.x Published: 01 January 1940
Predictors of Mortality and Mortality From Cardiac Causes in the Bypass Angioplasty Revascularization Investigation (BARI) Randomized Trial and Registry
Authors: Maria Mori Brooks, Robert H. Jones, Richard G. Bach, Bernard R. Chaitman, Morton J. Kern, Thomas A. Orszulak, Dean Follmann, George Sopko, Eugene H. Blackstone, Robert M. Califf
Journal: Circulation (2000)

Background —The impact of percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass grafting (CABG) on long-term mortality rates in the presence of various demographic, clinical, and angiographic factors is uncertain in the population of patients suitable for both procedures. Methods and Results —In the Bypass Angioplasty Revascularization Investigation (BARI) randomized trial and registry, 3610 patients who were eligible to receive PTCA and CABG were revascularized between 1989 and 1992. Multivariate Cox models were used to identify factors associated with 5-year mortality and cardiac mortality, with particular attention to factors that interact with treatment. Diabetic patients receiving insulin had higher mortality and cardiac mortality rates with PTCA compared with CABG (relative risk [RR] 1.78 and 2.63, respectively, P &lt;0.001), and patients with ST elevation had higher cardiac mortality rates with CABG than with PTCA (RR 4.08, P &lt;0.001). Factors most strongly associated with high overall mortality rates were insulin-treated diabetes, congestive heart failure, kidney failure, and older age. Black race was also associated with higher mortality rates (RR 1.49, P =0.019). Conclusions —A set of variables was identified that could be used to help select a revascularization procedure and to evaluate risk of long-term mortality in the population of patients considering revascularization.
Therapy vs No Therapy for Bacteriuria in Elderly Ambulatory Nonhospitalized Women
Authors: Jerome A. Boscia
Journal: JAMA (1987)

This prospective randomized study was undertaken to determine the efficacy of antimicrobial therapy compared with no therapy for bacteriuria in elderly ambulatory nonhospitalized women. Sixty-one women (mean age, 85.8 years) with bacteriuria were in the no therapy control group and 63 women (mean age, 85.8 years) with bacteriuria were in the therapy group; none had symptoms of urinary tract infection. One short course of antimicrobial therapy achieved a cure rate of 68.3% (43 of 63 women cured) two weeks after treatment. During the six-month follow-up period, ten (16.4%) of 61 women in the no therapy group and five (7.9%) of 63 women in the therapy group developed symptomatic urinary tract infection. At the time of six-month follow-up, 19 (34.5%) of 55 women in the no therapy group and 35 (63.6%) of 55 women in the therapy group did not have bacteriuria. We conclude that for asymptomatic bacteriuria in elderly ambulatory nonhospitalized women, short-course antimicrobial therapy is effective at two-week follow-up and that antimicrobial therapy can eliminate bacteriuria in most of these women for at least a six-month period.
Extracorporeal Shockwave Lithotripsy for Ureterolithiasis in Patients with Urinary Bilharziasis: Efficacy and Variables That Influence Treatment Outcome
Authors: Riyadh F. Talic, Salah H. Hassan, Salah R. El-Faqih, Ramiz Atassi, Abdulmoniem El Turaifi, Khalid Fouda Neel, Rabie E. Abdel Halim
Journal: European Urology (2000)
Rubella Immunization-Reply
Authors: Stephen C. Schoenbaum
Journal: JAMA (1976)

In Reply.—  We must agree to disagree, in the kitchen or wherever. Neither the British nor the US policy is yet ripe for evaluation on the basis of performance.  There are several problems with the line of reasoning that contends that mass vaccination of young children (as in the United States) must be effective at preventing rubella syndrome simply because relatively few cases are being reported. First, the intervals between epidemics of rubella syndrome appear to be longer and less predictable than those between epidemics of childhood rubella. 1 Moreover, trends other than vaccination are tending to restrict the incidence of rubella syndrome cases. If an epidemic the size of that in 1964 had struck in 1974, a 30% reduction in the number of cases would have occurred because of the declining birth rate alone. Trends in abortion counseling and availability would have further diminished the number considerably. For these