tbuckley/cabot-search huggingface dataset:
Erythropoiesis in vitro. Role of calcium.
Authors: J Misiti, J L Spivak
Journal: Journal of Clinical Investigation (1979)

The in vitro plasma clot technique was employed to examine the role of calcium during the interaction of erythropoietin and mouse erythroid progenitor cells. Erythropoietin-induced erythroid colony formation was increased 24% by the carboxylic ionophore A23187 (10 nM), whereas a 35% increase was produced by the carboxylic ionophore Ro 2-2985/1 (1 nM). EGTA (3 mM) inhibited erythropoietin-induced erythroid colony formation. Inhibition of erythroid colony formation by EGTA could be reversed by Ca2+, but not by Mn2+, Mg2+, Zn2+, or Fe2+. At least 30 min exposure of marrow cells to erythropoietin in vitro was required for production of erythroid colonies. EGTA substantially inhibited erythropoietin-induced erythroid colony formation even when the marrow cells were exposed to the hormone for up to 2 h before addition of the chelator. Marrow cells incubated first in calcium-free medium with erythropoietin and then cultured in the presence of calcium but not erythropoietin, failed to form erythroid colonies although colony formation occurred when erythropoietin was provided. Taken together, the data indicate that calcium is required for both extracellular and intracellular events during the interaction of erythropoietin with its target cells.
PULMONARY FIBROSIS IN SCLERODERMA
Authors: J. E. M. WIGLEY, V. EDMUNDS, R. BRADLEY
Journal: British Journal of Dermatology (1949)

Journal Article PULMONARY FIBROSIS IN SCLERODERMA Get access J. E. M. WIGLEY, M.B., F.R.C.P., J. E. M. WIGLEY, M.B., F.R.C.P. The Skin Department, Charing Cross Hospital Search for other works by this author on: Oxford Academic Google Scholar V. EDMUNDS, M.D., M.R.C.P., V. EDMUNDS, M.D., M.R.C.P. The Skin Department, Charing Cross Hospital Search for other works by this author on: Oxford Academic Google Scholar R. BRADLEY, M.B., Ch.B., N.Z. R. BRADLEY, M.B., Ch.B., N.Z. The Skin Department, Charing Cross Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 61, Issue 10, 1 October 1949, Pages 324–327, https://doi.org/10.1111/j.1365-2133.1949.tb11038.x Published: 01 October 1949
Modulation of the Random Migration of Human Platelets
Authors: Frank H. Valone, K. Frank Austen, Edward J. Goetzl
Journal: Journal of Clinical Investigation (1974)

Random migration of human platelets has been recognized as a parameter of platelet function which can be assessed in a reproducible manner by modification of the Boyden micropore filter technique for evaluating this function in other cells (Boyden, S. 1962. J. Exp. Med. 115: 453-466). Because platelets are extremely susceptible to aggregation, the conditions for collecting and isolating platelets and the migration buffer (Ca(++) and Mg(++)-free phosphate buffered saline, pH 6.8, with glucose and gelatin) were selected to minimize such a possibility. The random movement of platelets into the micropore filter was maximal at 30-37 degrees C and was contingent upon the metabolic integrity of the cell; thus, it can be attributed to active spontaneous migration. While the initiating and enhancing effects of epinephrine on the platelet aggregation-release reaction are mediated by an alpha-adrenergic receptor, the inhibition of random migration involved a beta-receptor. Equimolar propranolol but not phentolamine prevented epinephrine inhibition of random migration, and isoproterenol had activity comparable to epinephrine while phenylephrine was inactive. The capacity of the cholinomimetic agent, carbachol, to increase platelet migration is reminiscent of the recent findings in several cell systems in which beta-adrenergic and cholinergic stimuli have opposite effects. The prostaglandins E1 and E2 augmented spontaneous migration in contrast to their well established inhibitory action on platelet aggregation at the concentrations employed. The suppression by indomethacin of prostaglandin enhancement and of spontaneous migration implies a requirement for the prostaglandin biosynthetic pathway during the migration process. Thus, the spontaneous migration of human platelets, an additional parameter of platelet function for in vitro investigations, disclosed not only a beta-adrenergic receptor for epinephrine, but also a capacity for cholinergic augmentation and an apparent requirement for prostaglandin biosynthesis.
Sulindac. A potentially renal-sparing nonsteroidal anti-inflammatory drug
Authors: R. D. Bunning
Journal: JAMA (1982)

Three patients experienced rapidly reversible azotemia related to the use of naproxen or ibuprofen but tolerated full-dose sulindac. This article discusses renal toxicity of nonsteroidal anti-inflammatory drugs (NSAIDs), with emphasis on the role of inhibition of prostaglandin synthesis, and reviews evidence supporting a renal-sparing property of sulindac. The current literature assumes that all NSAIDs possess a similar potential for renal toxicity. The data presented suggest that sulindac has less potential for renal toxicity and may be the preferred NSAID for use in patients with impaired renal function. (<i>JAMA</i>1982;248:2864-2867)
Are Severe Combined Immune Deficiency (SCID) Cases Missed at a Children's Hospital?
Authors: P. Poowuttikul, N. Mireku, A. Kujawska, D. Gonzalez-Espinosa, P. Maitland-McKinley, W. Young, E. Secord, J. Puck
Journal: Journal of Allergy and Clinical Immunology (2011)
Training in psychosexual medicine
Authors: P Tunnadine
Journal: BMJ (1994)

EDITOR, - May Duddle's criticism of the Institute of Psychosexual Medicine's training is ill informed1 as she has taken no part in the institute's training, research, and development, which have been carried out nationwide for 30 years. I wish to set the record straight.

Doctors accepted for basic training must expect to meet patients who expect examination of their sexual organs as well as emotional understanding; in general practice, patients come for family planning, genitourinary medicine, gynaecology, and andrology. Certain nurses, midwives, and obstetric physiotherapists also have to use …
Selective Venous Sampling for ACTH in Cushing's Syndrome
Authors: Findling Jw, Aron Dc, Tyrrell Jb, Shinsako Jh, Fitzgerald Pa, Norman D, Wilson Cb, Forsham Ph
Journal: Annals of Internal Medicine (1981)

We performed selective venous catheterization and sampling for ACTH in six patients with ACTH-secreting pituitary adenomas (Cushing's disease) and four patients with occult ectopic ACTH-secreting neoplasms. In five patients with Cushing's disease in whom the inferior petrosal sinus could be catheterized, ACTH levels were unequivocally higher than simultaneous peripheral values: The ratio was greater than 2. 0, with a range of 2.2 to 16.7. In contrast, the inferior petrosal sinus-to-peripheral ACTH ratio in three patients with ectopic ACTH secretion was less than 1.5. In the fourth patient, an arteriovenous gradient of 6.8 was shown 2 years before a bronchial carcinoid tumor was clinically apparent. Central-to-peripheral ACTH ratios at the level of the jugular bulb and jugular vein were not diagnostic. We conclude that selective venous ACTH sampling from the inferior petrosal sinus is a reliable and useful aid in the differential diagnosis of Cushing's syndrome when standard clinical and biochemical studies are inconclusive.
Genetics and insurance: a possible solution.
Authors: Virginia Warren
Journal: BMJ (2001)

EDITOR—The interaction between clinical genetics and insurance is controversial. The remit of the government's Genetics and Insurance Committee is to assess the clinical and actuarial relevance of DNA test results to insurance practice. Its first ruling was that the industry could continue to use the results of DNA tests for Huntington's disease in underwriting applications for life insurance.

One way of dispelling much of the controversy surrounding genetics and insurance would be to establish whether access to insurance is a …
The prevalence of asthmatic respiratory symptoms among adults in Estonian and Swedish university cities
Authors: R. JõTgi, C. Janson, E. Björnsson, G. Bornan, B. Björkstén
Journal: Allergy (1996)

The prevalence of atopy and related diseases is lower among children in Eastern European countries than in countries with a market economy. Such comparisons have not been made in adults. The European Community Respiratory Health Survey (ECRHS) postal questionnaire was mailed to random samples of 3000 inhabitants in Tartu, Estonia, and 3600 in Uppsala, Sweden, between the ages of 20 and 44 years. Asthmatic symptoms (wheeze with breathlessness occurring in the absence of colds) were less prevalent in Tartu (4.6% vs 6.8%, P&lt; 0.001), as were attacks of asthma (1.9% vs 3.3%, P &lt;0.01), current asthma medication (0.7% vs 4.9%), and allergic rhinitis (17.8% vs 22.2%, P &lt;0.001). Age was inversely related to allergic rhinitis in Uppsala ( P &lt;0.05), but not in Tartu. Nocturnal respiratory symptoms (wakening with chest tightness or being woken by an attack of breathlessness or an attack of cough) were more prevalent in Tartu ( P&lt; 0.001), and their prevalence increased with age ( P &lt;0.05) in Tartu, but not in Uppsala. Symptoms of asthma and hay fever were less common but other respiratory problems more common in Tartu than in Uppsala. The difference in the prevalence of hay fever diminished with age, supporting the notion that the increasing prevalence of allergy among children and young adults in Western Europe is caused by a cohort effect.
New Viral Exanthems
Authors: A. MARTIN LERNER
Journal: Annals of Internal Medicine (1964)

Editorials1 April 1964New Viral ExanthemsA. MARTIN LERNER, M.D.A. MARTIN LERNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-703 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe specific eruptions of the classical viral exanthems, rubeola, varicella, herpes simplex, herpes zoster, and rubella have allowed the diagnosis of these illnesses at the bedside and enabled rational predictions of the probable course in these patients. The relatively recent propagation of these agents in tissue culture has added the possibility of vaccine prophylaxis, or specific chemotherapy, or both.However, during the summer and fall each year many children and some adults are seen by physicians with rashes that are clearly not one of the well-known eruptions. The same technology that has allowed the isolation of viruses from patients with...References1. LERNERKLEINCHERRYFINLAND AMJOJDM: New viral exanthems. New Eng. J. Med. 269: 678, 736, 1963. CrossrefMedlineGoogle Scholar2. LERNERCHERRYKLEIN AMJDJO: Virological studies of summer exanthems. Arch. Intern. Med. (Chicago) 110: 687, 1962. CrossrefMedlineGoogle Scholar3. NEVAFEEMSTERGORBACH FARFIJ: Clinical and epidemiological features of unusual epidemic exanthem. JAMA 155: 544, 1954. CrossrefMedlineGoogle Scholar4. NEVA FA: Second outbreak of Boston exanthem disease in Pittsburgh during 1954. New Eng. J. Med. 254: 838, 1956. CrossrefMedlineGoogle Scholar5. ROBINSONDOANERHODES CRFWAJ: Report of outbreak of febrile illness with pharyngeal lesions and exanthem: Toronto, summer 1957—isolation of group A Coxsackie virus. Canad. Med. Ass. J. 79: 615, 1958. MedlineGoogle Scholar6. ALSOPFLEWETTFOSTER JTHJR: "Hand-foot-and-mouth disease" in Birmingham in 1959. Brit. Med. J. 2: 1708, 1960. CrossrefMedlineGoogle Scholar7. MAGOFFINJACKSONLENNETTE RLEWEH: Vesicular stomatitis and exanthem: syndrome associated with Coxsackie virus, type A16. JAMA 175: 441, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: A. MARTIN LERNER, M.D.Affiliations: Wayne State University School of Medicine Detroit, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe diagnosis of the invasion of measles from a study of the exanthema as it appears on the buccal mucous membraneBakterielle InfektionenOn the Numbered ExanthemataMaul- und KlauenseucheMaul- und KlauenseucheViral and Viral-Like Diseases of the MouthBacterial Meningitis — A Review of Selected Aspects 1 April 1964Volume 60, Issue 4Page: 703-705KeywordsChemotherapyChildrenFallsHerpes simplexMeaslesProphylaxisRashesRubellaTissue culturesVaccines ePublished: 1 December 2008 Issue Published: 1 April 1964 PDF downloadLoading ...
Romanian doctors get pay rise
Authors: T. Toma
Journal: BMJ (1999)

The pay of Romanian doctors will go up by one third this month, after parliament's approval of the national budget for 1999.

In cash terms, their salaries will double, but after inflation is taken into account, the rise will be worth about 30 %. While doctors have seen a notional doubling of their salaries in the past, the real value of their income has tended not to change significantly because of the …
The Treatment of Chronic Ulcerative Colitis with Pituitary Adrenocorticotrophic Hormone (ACTH)
Authors: John M. Elliott, Everett D. Kiefer, Lewis M. Hurxthal
Journal: New England Journal of Medicine (1951)

THE use of adrenocortical steroids and the adrenocortical-stimulating hormone of the pituitary gland constitutes a distinctly new approach to the treatment of a number of diseases. It is obvious that the possibilities of this form of therapy as applied in chronic ulcerative colitis should be further explored, as only a few cases of this disease treated with ACTH have been reported.1 , 2 The rationale of adrenocortical stimulation as a therapeutic measure in the treatment of chronic ulcerative colitis may be divided into a group of clinical observations and the theoretical concepts that favor the indication that ACTH would be beneficially effective . . .
Pathology of Ionizing Radiation
Authors: Marshall Brucer
Journal: JAMA (1962)

Historically the science of pathology was influenced strongly by the science of anatomy. ( It still is. ) Then pathology was influenced by bacteriology, then biochemistry. Pathology is always influenced by physiology, otherwise it is not pathology. During the past quarter century, a fourth element is achieving its rightful place in the science of pathology. A purely physical agent—ionizing radiation —involves all sciences and affects all functions of the human body. One of the first physicians to study these effects was Shields Warren, Professor of Pathology at Harvard Medical School, consultant to innumerable experimental pathology organizations and societies, and the first director of the Division of Biology and Medicine of the U.S. Atomic Energy Commission.  Dr. Warren's monograph describes the subtle, sometimes delayed, and always confusing effects of ionizing radiation. The monograph follows a historical exposition interspersed with a systematic description of the effects of radiation. Throughout the document there are comments
Effect of Sulfonylurea Compounds in Diabetic Children
Authors: Rafael Camerini-Davalos, Alexander Marble, Priscilla White, Mimi Belmonte, Lynn Sargeant
Journal: New England Journal of Medicine (1957)

IT has been the experience of those who have used the sulfonylurea compounds that they are, for the most part, not effective in children with diabetes or in adults with unstable, juvenile type of diabetes. Our findings with Carbutamide** and Tolbutamide†† have been in agreement with this, and in only 19 cases have we attempted to treat such patients with the sulfonylureas. Nevertheless, it seemed desirable to ascertain in a sizeable group of children the effect of a single dose of these drugs since limited data indicated that in the occasional child a satisfactory hypoglycemic response might be obtained. In . . .
Book Review Approaching Death: Improving care at the end of life By the Committee on Care at the End of Life, Division of Health Care Services, Institute of Medicine. Edited by Marilyn J. Field and Christine K. Cassel. 437 pp. Washington, D.C., National Academy Press, 1997. $34.95. 0-309-06372-8
Authors: Judith C. Ahronheim
Journal: New England Journal of Medicine (1998)
Body mass index and chronic unexplained gastrointestinal symptoms: an adult endoscopic population based study
Authors: P Aro
Journal: Gut (2005)

We aimed to determine whether obese subjects experience more gastro-oesophageal reflux (GORS) symptoms than normal subjects, and further to determine if this association was explained by oesophagitis or medications that lower oesophageal sphincter pressure.In a representative Swedish population, a random sample (n = 1001, mean age 53.5 years, 51% women) had upper endoscopy. GORS was defined as any bothersome heartburn or acid regurgitation.The prevalence of obesity (body mass index > or =30) was 16%; oesophagitis was significantly more prevalent in obesity (26.5%) than in normal subjects (9.3%). There were associations between obesity and GORS (odds ratio (OR) 2.05 (95% confidence interval (CI) 1.39, 3.01)), epigastric pain (OR 1.63 (95% CI 1.05, 2.55)), irritable bowel symptoms (OR 1.58 (95% CI 1.05, 2.38)), any abdominal pain (OR 1.59 (95% CI 1.08, 2.35)), vomiting (OR 3.11 (95% CI 1.18, 8.20)), retching (OR 1.74 (95% CI 1.1.3, 2.67)), diarrhoea (OR 2.2 (95% CI 1.38, 3.46)), any stool urgency (OR 1.60 (95% CI 1.04, 2.47)), nocturnal urgency (OR 2.57 (95% CI 1.33, 4.98)), and incomplete rectal evacuation (OR 1.64 (95% CI 1.09, 2.47)), adjusting for age, sex, and education. When subjects with oesophagitis and peptic ulcer were excluded, only diarrhoea, incomplete evacuation, and vomiting were significantly associated with obesity. The association between GORS and obesity remained significant adjusting for medication use (OR 1.9 (95% CI 1.3, 3.0)).GORS is associated with obesity; this appears to be explained by increased upper endoscopy findings in obesity.
Orthotopic liver transplantation for type I Crigler-Najjar syndrome
Authors: Stuart S. Kaufman, Patrick R. Wood, Byers W. Shaw, Rodney S. Markin, Philip Rosenthal, Bruno Gridelli, Jon A. Vanderhoof
Journal: Hepatology (1986)

A neurologically normal 3-year-old girl with Type I Crigler-Najjar syndrome was successfully treated with orthotopic liver transplantation. Preoperative serum bilirubin concentrations as high as 31 mg per dl were not diminished with phenobarbital or phototherapy. Bilirubin fractionation of duodenal bile prior to transplantation revealed 87.1% unconjugated bilirubin and 12.9% monoconjugates as determined by alkaline methanolysis-high-performance liquid chromatography. Postoperatively, the serum bilirubin concentration quickly fell to normal. Uridine diphosphate glucuronyl transferase activity in the recipient liver was not detectable. The gallbladder bile bilirubin concentration of 23.9 mg per dl was less than 15% of previously reported normal values. Since devastating kernicteric brain injury is the invariable outcome of Type I Crigler-Najjar syndrome, liver transplantation should be performed when phototherapy cannot maintain the serum bilirubin concentration at an unequivocally safe level.
INCIDENTAL FINDINGS OF LEFT VENTRICULAR LATE GADOLINIUM ENHANCEMENT ON MAGNETIC RESONANCE IMAGING IN ATRIAL FIBRILLATION PATIENTS HAS A PROGNOSTIC VALUE FOR RECURRENCE AFTER ABLATION THERAPY
Authors: Promporn Suksaranjit, Krishna Velagapudi, Kavitha Damal, Lowell Chang, Allen Rassa, Erik Bieging, Brent Wilson, Nassir Marrouche, Christopher McGann
Journal: Journal of the American College of Cardiology (2014)
Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro
Authors: Xiao-Ming Meng, Xiao Ru Huang, Jun Xiao, Arthur C.K. Chung, Wei Qin, Hai-yong Chen, Hui Yao Lan
Journal: Kidney International (2011)
Therapeutic Abortion and the Psychiatrist
Authors: Z. ALEXANDER AARONS
Journal: American Journal of Psychiatry (1967)

The psychiatrist encounters many difficulties when requested to recommend a therapeutic abortion. To evaluate a pregnant woman's emotional fitness for motherhood, the psychiatrist must determine the nature of her neurotic conflicts, her ability to form object relationships, and her appreciation for reality conditions. State laws on therapeutic abortion disregard these criteria. To what extent a pregnancy or its termination has any crucial effect in altering a woman's basic emotional condition or in affecting a chronic emotional illness is questioned.
The Mechanical Appearance of the Journal of the American Medical Association.
Authors: Q. C. Smith
Journal: JAMA (1894)

Austin, Texas, Sept. 25, 1894. <h3>To the Editor:</h3> —OurJournalof September 22 tells the good news—of permanent advantages in publication. Allow me to congratulate you, and all the good doctors of the United States. When Dr. Hart came to the United States, some time ago, and gave us much—esoteric and exoteric— valuable information, on the momentous question, " just how to run a journal," he forgot the mechanical part. His small print, on poor thin paper, is a great trial to doctors eyes, and a punishment they do not merit; they<i>pay</i>him for something far better. The (Wakele's)<i>Lancet</i>, is just a<i>little</i>better; but it too is abominably bad print; its " export" edition specially bad, with its very thin paper and small print, OurJournalshows them the superior larger print and better paper, and has the appreciative thanks of American doctors. Is it not strange, that these
Regulation of the expression of tissue inhibitor of metalloproteinases and collagenase by retinoids and glucocorticoids in human fibroblasts.
Authors: S D Clark, D K Kobayashi, H G Welgus
Journal: Journal of Clinical Investigation (1987)

The regulation of the expression of interstitial collagenase and tissue inhibitor of metalloproteinases (TIMP) was examined in response to both retinoid compounds and glucocorticoids. Effective retinoids induced a dose-dependent, specific increase in the production of TIMP of approximately two- to threefold by monolayer cultures of human fibroblasts derived from various tissues, while simultaneously causing a decrease in collagenase secretion of similar magnitude. These effects were apparent by 8-12 h in culture and disappeared within 24 h after the withdrawal of retinoid compounds. The retinoid effect on TIMP production was mediated via an increased biosynthesis of new inhibitor protein. Similarly, increased steady state levels of TIMP messenger RNA (mRNA) accompanied by decreased quantities of collagenase mRNA were demonstrated, suggesting transcriptional control of the retinoid action. The data suggest that retinoids co-regulate the expression of collagenase and TIMP, and do so in an inverse manner. Dexamethasone caused a dose-dependent, specific decrease in collagenase production without altering the biosynthesis of TIMP. These findings were paralleled by a marked reduction in collagenase mRNA, without any accompanying change in TIMP mRNA. Therefore, TIMP and collagenase expression appear to be independently modulated by glucocorticoids.
Direct HIV testing of donated blood is inevitable
Authors: A. Legge
Journal: BMJ (1997)

The introduction of a polymerase chain reaction (PCR) test for HIV in donated blood products is inevitable, according to scientists at the National Blood Authority. They say, however, that such a move would result in a “quantum leap” in cost for doubtful benefit.

Testing directly for HIV, rather than the current antibody testing, would reduce the window of opportunity for missing infected blood from around three weeks to a matter of days. Three patients in northwest England recently contracted HIV infection from blood transfusions from a donor positive …
TCT-269 RAS Registry, Real world incidence of Spasm in Trans radial Intervention
Authors: Alejandro Goldsmit, John Coppola, Surya Dharma, Ian C. Gilchrist, Pablo E. Kantor, Sasko Kedev, Ferdinand Kiemeneij, Tak Kwan, Tejas Patel, Angel Puente, Leon Valdivieso, Bernhard Westerberg
Journal: Journal of the American College of Cardiology (2013)