tbuckley/cabot-search huggingface dataset:
Felty's Syndrome: Granulocyte-Bound Immunoglobulin G and Splenectomy
Authors: GERALD LOGUE
Journal: Annals of Internal Medicine (1976)

A quantitative antiglobulin consumption technique was used to measure immunoglobulin G (IgG) present on human granulocytes. Granulocytes from 50 normal subjects had less than 20 X 10-14 g IgG per cell. Patients with granulocytopenia due to bone-marrow failure, patients with IgG multiple myeloma, patients with splenomegaly, and patients with rheumatoid arthritis without granulocytopenia had granulocyte-bound IgG within the range of normal. Four patients with rheumatoid arthritis, splenomegaly, and severe granulocytopenia (Felty's syndrome) had granulocyte-bound IgG between 30 and 220 X 10-14 g IgG per cell. One of these patients underwent splenectomy, after which his granulocyte-bound IgG fell to normal. Seven additional patients with Felty's syndrome who had previously undergone splenectomy had normal levels of granulocyte-bound IgG. Thus quantitation of granulocyte-bound IgG appears to be useful in defining patients with immunologically mediated granulocytopenia. Studies of patients with Felty's syndrome who have undergone splenectomy suggest that the spleen may produce this neutrophile-bound immunoglobulin.
Haemodynamic response in soccer spectators: is Scottish football exciting?
Authors: A T Elder, S G Jyothinagaram, P L Padfield, T R Shaw
Journal: BMJ (1991)

OBJECTIVE--To determine the effect of watching a game of Scottish football on heart rate and blood pressure. DESIGN--Prospective study. SETTING--Two Scottish Premier League football grounds. SUBJECTS--10 healthy men, each a supporter of one of two clubs. MAIN OUTCOME MEASURES--Systolic and diastolic blood pressure and heart rate at home, while walking, and during the match. RESULTS--Systolic blood pressure and heart rate were significantly higher when the men were watching the match than when they were at home. While they were watching the match, heart rate was maximal immediately after a goal had been scored by the supported team. CONCLUSION--The emotional stress invoked by Scottish football is associated with significant increases in heart rate and systolic blood pressure.
The Challenge of Diagnosing Atheroembolic Renal Disease
Authors: Francesco Scolari, Pietro Ravani, Rossella Gaggi, Marisa Santostefano, Cristiana Rollino, Nevio Stabellini, Loredana Colla, Battista Fabio Viola, Paolo Maiorca, Chiara Venturelli, Stefano Bonardelli, Pompilio Faggiano, Brendan J. Barrett
Journal: Circulation (2007)

Background— Atheroembolic renal disease (AERD) is caused by showers of cholesterol crystals released by eroded atherosclerotic plaques. Embolization may occur spontaneously or after angiographic/surgical procedures. We sought to determine clinical features and prognostic factors of AERD. Methods and Results— Incident cases of AERD were enrolled at multiple sites and followed up from diagnosis until dialysis and death. Diagnosis was based on clinical suspicion, confirmed by histology or ophthalmoscopy for all spontaneous forms and for most iatrogenic cases. Cox regression was used to model time to dialysis and death as a function of baseline characteristics, AERD presentation (acute/subacute versus chronic renal function decline), and extrarenal manifestations. Three hundred fifty-four subjects were followed up for an average of 2 years. They tended to be male (83%) and elderly (60% &gt;70 years) and to have cardiovascular diseases (90%) and abnormal renal function at baseline (83%). AERD occurred spontaneously in 23.5% of the cases. During the study, 116 patients required dialysis, and 102 died. Baseline comorbidities, ie, reduced renal function, presence of diabetes, history of heart failure, acute/subacute presentation, and gastrointestinal tract involvement, were significant predictors of event occurrence. The risk of dialysis and death was 50% lower among those receiving statins. Conclusions— Clinical features of AERD are identifiable. These make diagnosis possible in most cases. Prognosis is influenced by disease type and severity.
Active symptom control with or without chemotherapy in the treatment of patients with malignant pleural mesothelioma (MS01): a multicentre randomised trial
Authors: Martin F Muers, Richard J Stephens, Patricia Fisher, Liz Darlison, Christopher MB Higgs, Erica Lowry, Andrew G Nicholson, Mary O'Brien, Michael Peake, Robin Rudd, Michael Snee, Jeremy Steele, David J Girling, Matthew Nankivell, Cheryl Pugh, Mahesh KB Parmar
Journal: The Lancet (2008)
Paying for Health — Pot and Pill — The Power of Television
Authors: John Lister
Journal: New England Journal of Medicine (1968)

AS part of its economy drive the Government has restored the prescription charges that it removed shortly after taking office in 1964 in fulfillment of one of its election promises.Although the announcement of the decision was greeted with angry protests from the members of the left wing of the Labour Party who remain dedicated to an entirely free Health Service at the time of need, there appeared little evidence of any similar resentment on the part of the general public.The proposed new charge is modest. Two shillings and sixpence (30 cents) will be charged for each item prescribed . . .
Pindolol acts as beta-adrenoceptor agonist in orthostatic hypotension: therapeutic implications.
Authors: A J Man in 't Veld, M A Schalekamp
Journal: BMJ (1981)

Three bedridden patients with severe orthostatic hypotension due to chronic autonomic failure were treated with pindolol (15 mg/day), a beta-adrenoceptor antagonist with partial agonist activity. While taking this drug the patients were free of orthostatic symptoms: they could walk, and standing blood pressure was maintained above 90/50 mm Hg. Supine heart rate rose during treatment by 12-21 beats/minute, and stroke volume and cardiac output by 12-24 ml and 1.5-3.1 l/min respectively. Supine blood pressure rose by 21-68 mm Hg systolic and 14-49 mm Hg diastolic. Pindolol 15 mg/day was therapeutically effective in these three patients with severe orthostatic hypotension due to chronic autonomic failure. Further studies in a larger series of patients are needed to confirm this result.
THE EFFECTS OF VENOUS CONGESTION OF THE LIMBS AND PHLEBOTOMY UPON RENAL CLEARANCES AND THE EXCRETION OF WATER AND SALT. II. STUDIES IN PATIENTS WITH CONGESTIVE FAILURE 1
Authors: Walter E. Judson, J. D. Hatcher, William Hollander, Meyer H. Halperin, Robert W. Wilkins
Journal: Journal of Clinical Investigation (1955)
The Public Health Information Infrastructure
Authors: Lawrence O. Gostin
Journal: JAMA (1996)

Our objectives were to review and analyze the laws in the 50 states, the District of Columbia, and Puerto Rico that regulate the acquisition, storage, and use of public health data and to offer proposals for reform of the laws on public health information privacy. Virtually all states reported some statutory protection for governmentally maintained health data for public health information in general (49 states), communicable diseases (42 states), and sexually transmitted diseases (43 states). State statutes permitted disclosure of data for statistical purposes (42 states), contact tracing (39 states), epidemiologic investigations (22 states), and subpoena or court order (14 states). The survey revealed significant problems that affect both the development of fair and effective public health information systems and the protection of privacy. Statutes may be silent about the degree of privacy protection afforded, confer weaker privacy protection to certain kinds of information, or grant health officials broad discretion
The Royal Colleges of Great Britain
Authors: John Nichols
Journal: JAMA (1967)

To the Editor:—  Your editorial on Lawson  ( 198 :1363, 1966) contains a minute error. It is mentioned that Tait was admitted as a 'member' of the Royal College of Surgeons of Edinburgh. The surgical colleges of Scotland, England, and Ireland have two classes of persons in their makeup. The royal colleges of Edinburgh and Ireland both have licentiates and fellows, written as LRCS (Edin) or (Eire) and FRCS (Edin) or (Eire), but neither has members. The Royal College of Surgeons of England has two classes, viz, members and fellows, written as MRCS or FRCS, but it has no licentiates. The royal colleges of physicians in Edinburgh, London, and Ireland each have three classes of persons in their makeup, viz, licentiates, members, and fellows. These classes of the colleges of Edinburgh and Ireland were written, at that time and still, as LRCP (Edin) or (Eire), MRCP (Edin) or (Eire), and
Quadrivalent Human Papillomavirus Vaccine and the Risk of Venous Thromboembolism
Authors: Nikolai Madrid Scheller, Björn Pasternak, Henrik Svanström, Anders Hviid
Journal: JAMA (2014)

A potential association between quadrivalent human papillomavirus (HPV) vaccination and venous thromboembolism (VTE) has been reported in 2 postlicensure safety studies.1,2 An analysis of the Vaccine Adverse Event Reporting System database found disproportionately high reporting of VTE following vaccination,1 and a study using the Vaccine Safety Datalink reported a doubling of VTE risk.2
Trends in the Quality of Care and Racial Disparities in Medicare Managed Care
Authors: Amal N. Trivedi, Alan M. Zaslavsky, Eric C. Schneider, John Z. Ayanian
Journal: New England Journal of Medicine (2005)

Since 1997, all managed-care plans administered by Medicare have reported on quality-of-care measures from the Health Plan Employer Data and Information Set (HEDIS). Studies of early data found that blacks received care that was of lower quality than that received by whites. In this study, we assessed changes over time in the overall quality of care and in the magnitude of racial disparities in nine measures of clinical performance.
1020-3 Evaluation of Aortic Regurgitation Using Digitally Determined Color Doppler Imaged Flow Convergence Acceleration: A Quantitative Study in Animals
Authors: Takahiro Shiota, Michael Jones, Russell S. Heinrich, Izumi Yamada, Ajit P. Yoganathan, David J. Sahn
Journal: Journal of the American College of Cardiology (1995)
EFFECT OF SODIUM INTAKE ON ABILITY OF HUMAN PLASMA TO INHIBIT RENAL Na+-K+-ADENOSINE TRIPHOSPHATASE IN VITRO
Authors: H.E. De Wardener, E.M. Clarkson, Lucille Bitensky, G.A. Macgregor, J. Alaghband-Zadeh, J. Chayen
Journal: The Lancet (1981)
Posterior Probability in Clinical Trials
Authors: GEORGE A. DIAMOND
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 March 1984Posterior Probability in Clinical TrialsGEORGE A. DIAMOND, M.D., JAMES S. FORRESTER, M.D.GEORGE A. DIAMOND, M.D.Search for more papers by this author, JAMES S. FORRESTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-3-457_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Ellison and Seney (1) (along with five others who corresponded with us directly) correctly detected an error in our article on clinical trials (2) in panel A of Figure 1. The posterior probability curves, although properly calculated by a computer, were improperly labeled by a mortal—a pernicious demonstration of Murphy's law. The labels should be identical to those in panel B. We apologize for the error. Our conclusion—that a statistically significant result may not support the truth of a tested hypothesis when sample size is small—is still supported, however, by reference to panel B. The statement by...References1. ELLISONSENEY DF. Analysis of data from clinical trials [Letter]. Ann Intern Med. 1983;99:875. MedlineGoogle Scholar2. DIAMONDFORRESTER GJ. Clinical trials and statistical verdicts: probable grounds for appeal. Ann Intern Med. 1983;98:385-94. LinkGoogle Scholar3. ELLENBERGWITTES SJ. Analysis of data from clinical trials [Letter]. Ann Intern Med. 1983;99:874. LinkGoogle Scholar4. DIAMONDFORRESTER GJ. Analysis of data from clinical trials [Letter]. Ann Intern Med. 1983;99:874-5 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cedars-Sinai Medical Center UCLA School of Medicine Los Angeles, CA 90048 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCoronary CT angiography for patients with suspected coronary artery diseaseThe Role of Noninvasive Imaging in Coronary Artery Disease Detection, Prognosis, and Clinical Decision Making 1 March 1984Volume 100, Issue 3Page: 457-457KeywordsClinical trialsComputers Issue Published: 1 March 1984 PDF DownloadLoading ...
Making numbers out of magnitudes
Authors: Bradley J. Morris, Amy M. Masnick
Journal: Behavioral and Brain Sciences (2008)

Abstract We argue that number principles may be learnable instead of innate, by suggesting that children acquire probabilistically true number concepts rather than algorithms. We also suggest that non-propositional representational formats (e.g., mental models) may implicitly provide information that supports the induction of numerical principles. Given probabilistically true number concepts, the problem of the acquisition of mathematical principles is eliminated.
Passive Immunization against Chicken Pox
Authors: Charles A. Janeway
Journal: New England Journal of Medicine (1969)

The paper in this issue on "Prevention of Varicella by Zoster Immune Globulin" (ZIG) provides convincing evidence that 2 ml of gamma globulin, prepared from pooled plasma of patients convalescing from herpes zoster with complement-fixing antibody titers of at least 1:256, prevented varicella in susceptible children exposed to a sibling with the disease when ZIG was administered within 72 hours of onset of disease in the initial case. An equivalent dose of standard immune serum globulin given to another susceptible sibling was not protective, as in previous trials of much larger doses.1 This study is a model of clinical research, . . .
Treatment of Gangrene of the Feet and Legs by Walking
Authors: WILLIAM T. FOLEY
Journal: Circulation (1957)

In addition to the usual procedures in the treatment of arterial insufficiency with gangrene of the feet or legs, the author suggests exercise to stimulate collateral blood flow and improve the metabolic state of the involved tissues. After careful protection of the damaged parts, patients were encouraged to stand and walk. The results of this ambulatory regimen in 22 patients are presented.
Reproducible, Quantitative, and Flexible Molecular Subtyping of Clinical DLBCL Samples Using the NanoString nCounter System
Authors: Margaret H. Veldman-Jones, Zhongwu Lai, Mark Wappett, Chris G. Harbron, J. Carl Barrett, Elizabeth A. Harrington, Kenneth S. Thress
Journal: Clinical Cancer Research (2014)

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with distinct molecular subtypes. The most established subtyping approach, the "Cell of Origin" (COO) algorithm, categorizes DLBCL into activated B-cell (ABC) and germinal center B-cell (GCB)-like subgroups through gene expression profiling. Recently developed immunohistochemical (IHC) techniques and other established methodologies can deliver discordant results and have various technical limitations. We evaluated the NanoString nCounter gene expression system to address issues with current platforms.We devised a scoring system using 145 genes from published datasets to categorize DLBCL samples. After cell line validation, clinical tissue segmentation was tested using commercially available diagnostic DLBCL samples. Finally, we profiled biopsies from patients with relapsed/refractory DLBCL enrolled in the fostamatinib phase IIb clinical trial using three independent RNA expression platforms: NanoString, Affymetrix, and qNPA.Diagnostic samples showed a typical spread of subtypes with consistent gene expression profiles across matched fresh, frozen, and formalin-fixed paraffin-embedded tissues. Results from biopsy samples across platforms were remarkably consistent, in contrast to published IHC data. Interestingly, COO segmentation of longitudinal fostamatinib biopsies taken at initial diagnosis and then again at primary relapse showed 88% concordance (15/17), suggesting that COO designation remains stable over the course of disease progression.DLBCL segmentation of patient tumor samples is possible using a number of expression platforms. However, we found that NanoString offers the most flexibility and fewest limitations in regards to robust clinical tissue subtype characterization. These subtype distinctions should help guide disease prognosis and treatment options within DLBCL clinical practice.
Regulatory functions of hapten-reactive helper and suppressor T lymphocytes. II. Selective inactivation of hapten-reactive suppressor T cells by hapten-nonimmunogenic copolymers of D-amino acids, and its application to the study of suppressor T-cell effect on helper T-cell development
Authors: T Hamaoka, M Yoshizawa, H Yamamoto, M Kuroki, M Kitagawa
Journal: The Journal of Experimental Medicine (1977)

An experimental condition was established in vivo for selectively eliminating hapten-reactive suppressor T-cell activity generated in mice primed with a para-azobenzoate (PAB)-mouse gamma globulin (MGG)-conjugate and treated with PAB-nonimmunogenic copolymer of D-amino acids (D- glutamic acid and D-lysine; D-GL). The elimination of suppressor T-cell activity with PAB-D-GL treatment from the mixed populations of hapten- reactive suppressor and helper T cells substantially increased apparent helper T-cell activity. Moreover, the inhibition of PAB-reactive suppressor T-cell generation by the pretreatment with PAB-D-GL before the PAB-MGG-priming increased the development of PAB-reactive helper T-cell activity. The analysis of hapten-specificity of helper T cells revealed that the reactivity of helper cells developed in the absence of suppressor T cells was more specific for primed PAB-determinants and their cross-reactivities to structurally related determinants such as meta-azobenzoate (MAB) significantly decreased, as compared with the helper T-cell population developed in the presence of suppressor T lymphocytes. In addition, those helper T cells generated in the absence of suppressor T cells were highly susceptible to tolerogenesis by PAB-D- GL. Similarly, the elimination of suppressor T lymphocytes also enhanced helper T-cell activity in a polyclonal fashion in the T-T cell interactions between benzylpenicilloyl (BPO)-reactive T cells and PAB- reactive T cells after immunization of mice with BPO-MGG-PAB. Thus inhibition of BPO-reactive suppressor T-cell development by the BPO-v-GL- pretreatment resulted in augmented generation of PAB-reactive helper T cells with higher susceptibility of tolerogenesis to PAB-D-GL. Thus, these results support the notion that suppressor T cells eventually suppress helper T-cell activity and indicate that the function of suppressor T cells related to helper T-cell development is to inhibit the increase in the specificity and apparent affinity of helper T cells in the primary immune response. The hapten-reactive suppressor and helper T lymphocytes are considered as a model system of T cells that regulate the immune response, and the potential applicability of this system to manipulating various T cell-mediated immune responses is discussed in this context.
PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
Authors: Domingo F Barber, Almira Bartolomé, Carmen Hernandez, Juana M Flores, Clara Redondo, Cristina Fernandez-Arias, Montserrat Camps, Thomas Rückle, Matthias K Schwarz, Santiago Rodríguez, Carlos Martinez-A, Dimitrios Balomenos, Christian Rommel, Ana C Carrera
Journal: Nature Medicine (2005)
Severe isolated allergy to <i>Ficus benjamina</i> after bedroom exposure
Authors: P. Schmid, P. Stöger, B. Wüthrich
Journal: Allergy (1993)

Allergies to Ficus benjamina (Fb, weeping fig) have been described first as an occupational disease in plant keepers and later in clearly atopic subjects with known sensitizations to other inhalant allergens. We report a case of a hitherto nonatopic man with allergic rhinoconjunctivitis, contact urticaria, and asthma caused by a Fb kept in his bedroom for 18 months. Rubbing and skin prick test with native fig leaves and sap, and RAST to Fb were clearly positive. No other sensitization could be detected. After eliminating his Fb , he became asymptomatic within a few months. This case shows that private close contact to Fb can also induce allergy even in hitherto nonatopic subjects. Therefore, Fb should not be kept in bedrooms.
ABO blood group and ischaemic heart disease in British men.
Authors: P H Whincup, D G Cook, A N Phillips, A G Shaper
Journal: BMJ (1990)

OBJECTIVE--To establish whether ABO blood group is related to ischaemic heart disease on an individual and geographic basis in Britain. DESIGN--Prospective study of 7662 men with known ABO blood group selected from age-sex registers in general practices in 24 British towns. MEASUREMENTS--ABO blood group, standard cardiovascular risk factors, social class, and presence or absence of ischaemic heart disease determined at entry to study. END POINTS--Eight year follow up of fatal and nonfatal ischaemic heart disease events achieved for 99% of study population. RESULTS--Towns with a higher prevalence of blood group O had higher incidences of ischaemic heart disease. In individual subjects, however, the incidence of ischaemic heart disease was higher in those with group A than in those with other blood groups (relative risk 1.21, 95% confidence limits 1.01 to 1.46). Total serum cholesterol concentration was slightly higher in subjects of blood group A. No other cardiovascular risk factor (including social class) was related to blood group. CONCLUSIONS--Blood group A is related to the incidence of ischaemic heart disease in individual subjects. Geographic differences in the distribution of ABO blood groups do not explain geographic variation in rates of ischaemic heart disease in Britain. The findings do not support the view that ABO blood group and social class are related.
Topics in Hypertension
Authors: Ethan A. H. Sims
Journal: JAMA (1981)

Dr John Laragh, H. Altshul Master Professor of Medicine at New York Hospital-Cornell Medical Center, has long been in the forefront of research on hypertension. The present volume, to which a number of authorities in the field have contributed, brings together and places in perspective the impressive body of work from this laboratory. Dr Laragh is the author of five of the chapters and is coauthor of an additional seven of the 36 chapters. In his introduction, Laragh states that the book is intended to be a resource for concerned physicians to complement their knowledge and that it is directed to the practicing physician with a special interest in high blood pressure. The major focus of the book is concerned with measurement of plasma renin activity and its clinical utility in hypertension. Inappropriately high values are considered to be indicative of vasoconstriction and increased sympathetic activity, responsive to β-blocking, while
One million people die on world's roads every year
Authors: Owen Dyer
Journal: BMJ (2004)

Nearly 1.2 million people die each year on the world's roads, and the number will rise by 65% over the first two decades of this century, says a report published this week by the World Health Organization and the World Bank. Most of the extra deaths will occur in the developing world.



Road traffic injuries and deaths are a major public health crisis that is being neglected by governments and the media, concludes the report, which …
Imaging of Vascular Inflammation With [11C]-PK11195 and Positron Emission Tomography/Computed Tomography Angiography
Authors: Francesca Pugliese, Oliver Gaemperli, Anne R. Kinderlerer, Frederic Lamare, Joseph Shalhoub, Alun Huw Davies, Ornella E. Rimoldi, Justin C. Mason, Paolo G. Camici
Journal: Journal of the American College of Cardiology (2010)