tbuckley/cabot-search huggingface dataset:
LONG-TERM OUTCOME OF AORTIC VALVE PLASTY UTILIZING AN AUTOLOGOUS PERICARDIAL PATCH IN PATIENTS WITH SEVERE AORTIC STENOSIS
Authors: Takenori Otsuka, Makoto Suzuki, Hisao Yoshikawa, Youko Ishikawa, Takako Tsuchida, Tsukasa Osaki, Go Hashimoto, Masayoshi Matsuyama, Hiromasa Yamashita, Shin Uchida, Masao Moroi, Masato Nakamura, Shigeyuki Ozaki, Kaoru Sugi
Journal: Journal of the American College of Cardiology (2011)
Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients
Authors: Michaela Semeraro, Sylvie Rusakiewicz, Véronique Minard-Colin, Nicolas F. Delahaye, David Enot, Frédéric Vély, Aurélien Marabelle, Benjamin Papoular, Christelle Piperoglou, Mirco Ponzoni, Patrizia Perri, Andrei Tchirkov, Jessica Matta, Valérie Lapierre, Tala Shekarian, Sandrine Valsesia-Wittmann, Frédéric Commo, Nicole Prada, Vichnou Poirier-Colame, Brigitte Bressac, Sophie Cotteret, Laurence Brugieres, Françoise Farace, Nathalie Chaput, Guido Kroemer, Dominique Valteau-Couanet, Laurence Zitvogel
Journal: Science Translational Medicine (2015)

Natural killer cell activity and NKp30/B7-H6 interaction are prognostic biomarkers in high-risk neuroblastoma patients.
Extracellular vesicles: small but strong
Authors: M. C. Martinez
Journal: Cardiovascular Research (2013)

Pulmonary arterial hypertension (PAH) is a disease affecting small pulmonary arteries characterized by hyperplasia and hypertrophy of vascular smooth muscle cells and enhanced proliferation of endothelial cells. These events result in a remodelling of pulmonary vessels leading to an increase in the mean pulmonary arterial pressure and right ventricle overload and, ultimately, death. Growing evidences based on data obtained in patients with PAH indicate that the severity of PAH is associated with an increase of circulating small extracellular vesicles1,2 released from cells undergoing apoptosis or stimulation. Several discrepancies have been described concerning the origin of these vesicles in PAH, probably due to the heterogeneity of patients. These drawbacks may be overcome by using animal models of PAH induced by chronic hypoxic conditions3 or by monocrotaline treatment4. Besides being biomarkers, extracellular vesicles can also serve to transfer a large number of messages between cells due to their protein, lipid, and cytoplasmic contents (e.g. mRNA and miRNA).4,5

In this volume of Cardiovascular Research , Aliotta et al .6 have studied the role of extracellular microvesicles from monocrotaline-treated mice on the induction of pulmonary hypertensive changes. These vesicles are heterogeneous in size (30–423 nm) and carry proteins characteristic of exosomes and microparticles. Interestingly, the …
Severe periconceptional life events and the sex ratio in offspring: follow up study based on five national registers
Authors: D. Hansen, H. Moller, J. Olsen
Journal: BMJ (1999)

Exposure to smog, floods, 1 or earthquakes 2 has been associated with a lower sex ratio (proportion of males) in offspring conceived at the time of the exposure episode.We hypothesised that exposure to severe life events before and during the periconceptional period might be associated with a decline in the sex ratio.
Trouble With References
Authors: Erhard Sanders
Journal: JAMA (1969)

<h3>To the Editor:—</h3> In reviewing the literature on the Pickwickian syndrome (cardiopulmonary-obesity syndrome), we repeatedly found a reference to the following article: Piorry, P.A.: Influence de la pesanteur sur le cours du sang; diagnostic de la syncope et de l'apoplexie,<i>J Hebd Med</i><b>2</b>:292, 1826. A fine, full-sounding citation, conjuring up the picture of a learned physician disclosing his latest findings in elegant French to a distinguished assembly of equally learned, equally bearded colleagues! It seems to be so pertinent, too: "The influence of heaviness (obesity?) on the blood circulation," and of course reflects splendidly on the painstaking researcher who, poring over dusty tomes in a collection of rare medical journals, discovered this gem, perhaps the first attempt to establish a connection between obesity and syncope. It proved rather difficult to locate the original article, especially when we learned that<i>Journal Hebdomadaire de Médecine</i>, according to the<i>Union List</i>
Are patient consent forms for research protocols easy to read?
Authors: K. A. Priestley, C. Campbell, C. B. Valentine, D. M. Denison, N. P. Buller
Journal: BMJ (1992)

amplification, ploidy, raised serum activities of ferritin and neurone specific enolase."1Whether there is a progression from good to bad features remains contro- versial, although most of the evidence suggests that these features are constant within a given tumour.'6
Delineation of antigen-specific and antigen-nonspecific CD8+ memory T-cell responses after cytokine-based cancer immunotherapy
Authors: Julia K. Tietze, Danice E. C. Wilkins, Gail D. Sckisel, Myriam N. Bouchlaka, Kory L. Alderson, Jonathan M. Weiss, Erik Ames, Kevin W. Bruhn, Noah Craft, Robert H. Wiltrout, Dan L. Longo, Lewis L. Lanier, Bruce R. Blazar, Doug Redelman, William J. Murphy
Journal: Blood (2012)
Reduced miR-146a Increases Prostaglandin E<sub>2</sub> in Chronic Obstructive Pulmonary Disease Fibroblasts
Authors: Tadashi Sato, Xiangde Liu, Amy Nelson, Masanori Nakanishi, Nobuhiro Kanaji, Xingqi Wang, Miok Kim, Yingji Li, Jianhong Sun, Joel Michalski, Amol Patil, Hesham Basma, Olaf Holz, Helgo Magnussen, Stephen I. Rennard
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Persistent inflammation plays a major role in chronic obstructive pulmonary disease (COPD) pathogenesis, but its mechanisms are incompletely defined. Overproduction of the inflammatory mediator prostaglandin (PG) E₂ by COPD fibroblasts contributes to reduced repair function.The present study determined if fibroblasts from subjects with COPD overproduce PGE₂ after stimulation with the inflammatory cytokines IL-1β and tumor necrosis factor-α, and further defined the mechanism for overproduction.Fibroblasts were isolated from parenchymal tissue obtained from smokers with and without COPD undergoing lung surgery. PGE₂, cyclooxygenases (COX), and miR-146a in these cells were evaluated by in vitro studies.After stimulation with inflammatory cytokines, COPD fibroblasts produced 2.7-fold more PGE₂ compared with controls with similar smoking history. The increase in PGE₂ depended on induction of COX-2, which increased to a greater degree in fibroblasts from subjects with COPD. Cytokines also induced microRNA miR-146a expression in both fibroblasts, but significantly less in COPD fibroblasts. miR-146a caused degradation of COX-2 mRNA; reduced expression prolonged COX-2 mRNA half-life in fibroblasts from subjects with COPD. Cytokine-stimulated PGE₂ production and miR-146a expression in cultured fibroblasts correlated with clinical severity assessed by expiratory airflow and diffusion capacity.miR-146a seems to play a pathogenetic role in the abnormal inflammatory response in COPD. Increased half-life of inflammatory mRNAs is a mechanism of abnormal inflammation in this disease.
A New Antiseptic Dressing
Authors: H. L. Snow
Journal: BMJ (1880)

2-Z6I3WCJOURN4.[Marcb 27, i Bo.*~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~4 _ * _ -ws neyer any snidll notited&.-At >the.comxneEaerehtt!,f! s87C,he tXtended St. Mary's Hospital, and frfsome:moqthsrwasgien ioideof J-ootissium, as hehad'contrtucted a-csancre fift eaeyweviously.FHe -had never since the sore been"affected ;with .a"sysecosdttrysyniptotns.This4treatmeikt gave him no relief.In the, earlypart of,the winter of 1877, he came 'under.my care, and said that'afior the -third application of the spray he began to feel better.The spray was continued!for o«er t~wd t4ionths, the patient attending two or three' times a -week, no inter- rifl'remedies being given.Sincethen there has been no returin of the iditcharge, or any recurrence of thefattacks of sneezing.REMARKS.-These cases are, with one exception, all typical cases of sirmple oranna.'They presented most of.the common symptoms of the coifrplaint, Nvhi4th are: congestion of the imucous mnembrane with, -eonynly, slight thickening; crustations of dried mucus blocking up tWe'nestrils, which, on being removed, Adiscover ulceration of the mucous iutface, and occasionally destruction of;bone; a constant discharge, either scanty or copious, thin.or-,thick; perhaps-,mixedr with blood, and frequently so offensive thatlte.j sufferer is debmrredfiom society; a -running of the discharge, when the patient is -lying down, into the -'laynx.In two cases' in which the patients have suffered:from chronic 'bLkyngitig previous to incurring ozena, the i-rritation caused by this Jgta4itation of the nasal discharge hasi materially helped, it would '.een,; to keep up the laryngeal -congestion.Pain in or about the nostrils, or a feeling of discomfort, severe enough to keep the patient awake at night; redness of the skin over the bridge of the nose; the eiyes, or eyesight are in some cases affected.During the catamenial
Neuropathy and fatal hepatitis in a patient receiving amiodarone.
Authors: P K Lim, P N Trewby, G C Storey, D W Hole
Journal: BMJ (1984)

Muscle weakness, neuropathy, and transient rises in hepatic enzyme activity have been reported with the use of the antiarrhythmic agent amiodarone. A 68 year old teetotaller with normal liver function was given amiodarone for resistant supraventricular arrhythmias. He presented 19 months later with vomiting, muscle weakness and wasting, sensory neuropathy, and hepatomegaly. Liver biopsy showed fibrosis and the presence of hyaline. The amiodarone was withdrawn. Three months later he developed ascites. Oesophageal varices were found and he later died. The liver showed micronodular cirrhosis. The large volume of distribution and long half life of amiodarone may explain the persistence of toxicity, which may have been aggravated by simultaneously administered doxepin in this case. Amiodarone should be withdrawn if abnormal liver function or neuropathy develops.
New insight into mechanisms of pruritus from molecular studies on familial primary localized cutaneous amyloidosis
Authors: A. Tanaka, K. Arita, J.E. Lai-Cheong, F. Palisson, M. Hide, J.A. McGrath
Journal: British Journal of Dermatology (2009)

Macular and lichen amyloidosis are common variants of primary localized cutaneous amyloidosis (PLCA) in which clinical features of pruritus and skin scratching are associated with histological findings of deposits of amyloid staining on keratinous debris in the papillary dermis. Most cases are sporadic, but an autosomal dominant family history may be present in up to 10% of cases, consistent with a genetic predisposition in some individuals. Familial PLCA has been mapped to a locus on 5p13.1-q11.2 and in 2008 pathogenic heterozygous missense mutations were identified in the OSMR gene, which encodes oncostatin M receptor beta (OSMRbeta), an interleukin (IL)-6 family cytokine receptor. OSMRbeta is expressed in various cell types, including keratinocytes, cutaneous nerves and nociceptive neurones in dorsal root ganglia; its ligands are oncostatin M and IL-31. All pathogenic mutations are clustered in the fibronectin-III repeat domains of the extracellular part of OSMRbeta, sites that are critical for receptor dimerization (with either gp130 or IL-31RA), and lead to defective signalling through Janus kinase-signal transducers and activators of transcription, extracellular signal-regulated protein kinase 1/2 and phosphoinositide 3 kinase/Akt pathways. Elucidating the molecular pathology of familial PLCA provides new insight into mechanisms of pruritus in human skin, findings that may have relevance to developing novel treatments for skin itching. This review provides a clinicopathological and molecular update on familial PLCA.
The clinical relevance of minor paroxysmal nocturnal hemoglobinuria clones in refractory cytopenia of childhood: a prospective study by EWOG-MDS
Authors: A M Aalbers, V H J van der Velden, A Yoshimi, A Fischer, P Noellke, C M Zwaan, I Baumann, H B Beverloo, M Dworzak, H Hasle, F Locatelli, B De Moerloose, G Göhring, M Schmugge, J Stary, M Zecca, A W Langerak, J J M van Dongen, R Pieters, C M Niemeyer, M M van den Heuvel-Eibrink
Journal: Leukemia (2013)
Death Associated with Hypocalcemia after Small-Bowel Short Circuiting
Authors: William E. DeMuth, Hans S. Rottenstein
Journal: New England Journal of Medicine (1964)

SMALL-bowel short circuiting for the control of extreme, intractable obesity has been cautiously approached by several surgeons. One of the most attractive features of this procedure is its reversibility. This operation has usually been combined with procedures done to correct other difficulties, the most common being incisional hernia. Weight loss is usually dramatic. Studies of some of the nutritional aspects of this state have been reported after both intentional short circuiting and massive resection.1 2 3 4 That these patients are candidates for various complications of the "malabsorption syndrome" is not surprising, and difficulties with calcium absorption as part of this syndrome are . . .
Immunohistochemical demonstration of pancreatic α-amylase and trypsin in intrahepatic bile ducts and peribiliary glands
Authors: Tadashi Terada, Yasuni Nakanuma
Journal: Hepatology (1991)

Epithelia of intrahepatic bile ducts and peribiliary glands were immunohistochemically examined for pancreatic alpha-amylase and trypsin in 54 normal autopsied livers. alpha-Amylase was evaluated with a polyclonal antibody, and trypsin was assayed with both polyclonal and monoclonal antibodies. alpha-Amylase was observed in large ducts, septal ducts and peribiliary glands in most livers and was seen in interlobular ducts in seven (13%) livers. Trypsin immunoreactivity with the polyclonal antibody was observed in peribiliary glands in 21 (39%) livers; it was absent in intrahepatic bile ducts in all but one liver. Trypsin immunoreactivity with the monoclonal antibody was present in large ducts, septal ducts and peribiliary glands in about 70% of the livers and was seen in interlobular ducts in two (4%) livers. Bile ductules were always negative for the two antigens. Some epithelia of peribiliary glands positive for both alpha-amylase and trypsin histologically resembled pancreatic acinar cells. alpha-Amylase and trypsin immunoreactivities of intrahepatic biliary epithelia and pancreatic aninar cells were eliminated by absorption of primary antibodies by alpha-amylase or trypsin, suggesting the specificities of the immunoreactivities. These data suggest that epithelia of intrahepatic large ducts, septal ducts and peribiliary glands contain pancreatic alpha-amylase in most livers and that they contain trypsin in about 70% of livers. alpha-Amylase and trypsin may be secreted into intrahepatic bile duct lumens, thereby exerting important effects on the physiology of the intrahepatic biliary tree and hepatic bile.
Growth control or terminal differentiation: endogenous production and differential activities of vitamin A metabolites in HL-60 cells.
Authors: T M Eppinger, J Buck, U Hämmerling
Journal: The Journal of Experimental Medicine (1993)

Vitamin A (retinol) is a prohormone that exerts its pleiotropic biological effects after conversion into multiple metabolites. In this report we describe the identification of three endogenous, retinolderived effector molecules, 14-hydroxy-retro-retinol (14-HRR), anhydroretinol (AR), and retinoic acid (RA) and a putative storage form of retinol, retinylesters (RE) in the human promyelocytic leukemia cell line HL-60. Exogenous application of the retinol metabolites in retinol-depleted serum-free cultures of HL-60 allowed the identification of unique cellular functions for each metabolite: 14-HRR is a growth factor for HL-60. AR is a functional antagonist of 14-HRR with growth-inhibiting activity, and RA is a potent inducer of granulocyte differentiation accompanied by growth arrest. Finally, intracellular RE serves as storage form allowing continuous production of 14-HRR when no external retinol is available.
Reversion mutations in patients with leukocyte adhesion deficiency type-1 (LAD-1)
Authors: Gulbu Uzel, Emilia Tng, Sergio D. Rosenzweig, Amy P. Hsu, Jacqueline M. Shaw, Mitchell E. Horwitz, Gilda F. Linton, Stacie M. Anderson, Martha R. Kirby, Jaõ B. Oliveira, Margaret R. Brown, Thomas A. Fleisher, S. K. Alex Law, Steven M. Holland
Journal: Blood (2007)
Calculating Bootstrap Probabilities of Phylogeny Using Multilocus Sequence Data
Authors: T.-K. Seo
Journal: Molecular Biology and Evolution (2008)

Phylogeny estimation is extremely crucial in the study of molecular evolution. The increase in the amount of available genomic data facilitates phylogeny estimation from multilocus sequence data. Although maximum likelihood and Bayesian methods are available for phylogeny reconstruction using multilocus sequence data, these methods require heavy computation, and their application is limited to the analysis of a moderate number of genes and taxa. Distance matrix methods present suitable alternatives for analyzing huge amounts of sequence data. However, the manner in which distance methods can be applied to multilocus sequence data remains unknown. Here, we suggest new procedures to estimate molecular phylogeny using multilocus sequence data and evaluate its significance in the framework of the distance method. We found that concatenation of the multilocus sequence data may result in incorrect phylogeny estimation with an extremely high bootstrap probability (BP), which is due to incorrect estimation of the distances and intentional ignorance of the intergene variations. Therefore, we suggest that the distance matrices for multilocus sequence data be estimated separately and these matrices be subsequently combined to reconstruct phylogeny instead of phylogeny reconstruction using concatenated sequence data. To calculate the BPs of the reconstructed phylogeny, we suggest that 2-stage bootstrap procedures be adopted; in this, genes are resampled followed by resampling of the sequence columns within the resampled genes. By resampling the genes during calculation of BPs, intergene variations are properly considered. Via simulation studies and empirical data analysis, we demonstrate that our 2-stage bootstrap procedures are more suitable than the conventional bootstrap procedure that is adopted after sequence concatenation.
The Bradshaw Lecture on Sir Astley Cooper and his Surgical Work: Delivered before the Royal College of Surgeons of England on December 7th
Authors: W. Mac Cormac
Journal: BMJ (1893)

commenced by referring to the great change which had been brought about in surgery by the discovery of ansesthetics and by the intro- duction of the antiseptic system.In comparing the surgery of this day and that the revolution worked by these two discoveries must constantly be borne in mind.In Cooper's early days the English school of surgery was led by Percival Pott and John Hunter, but Cooper also felt the influence of Desault, Dupuytren, Lisfrane, and Delpech in Paris, Dieffen- bach in Berlin, and Scarpa in Italy.His immediate master in London was Cline.Cooper, who was born in 1768, began to lecture in London in 1791, and in 1793, when only 25 years of age, he became Professor of Anatomy in Surgeons' Hall.Formerly, anatomy and surgery had been taught by the same lecturer, but Cooper devoted himself to developing the subject of surgery into a separate course.and his lectures upon its principles and practice proved the foundation of his subsequent fame.His lectures were lavishly illustrated by dissections and preparations made by him or under his super- vision.To sueh a degree did he carry this that South estimated that the preparations, drawings, and dissections for a single course must have cost £1,000.
Is the Tumor Board Doomed?
Authors: D. L. Wishart
Journal: JAMA (1976)

<h3>To the Editor.—</h3> Dr Smith (233:1048, 1975) has suggested that the tumor board is no longer an effective educational mechanism and asks whether or not it will "eventually disappear from the medical scene as an archaic and useless instrument that has fallen to specialistic progress." Apparently, his doubts about its usefulness are based on his own experience in a moderately large hospital of the Veterans Administration system and on a survey of 87 other VA hospitals. Although he does not describe the details of the survey method, I wonder if the opinions derived therefrom constitute a fair sampling of the opinions of hospital staff members. While Dr Smith indicates that the<i>hospitals</i>responded to the survey, I am quite certain the response was more personal, generated by a real, live, human being and therefore conditioned by the usual human subjectiveness. The Association of Community Cancer Centers (ACCC), formed 18 months
Collapse of the Tumor Stroma is Triggered by IL-12 Induction of Fas
Authors: Sid P Kerkar, Anthony J Leonardi, Nicolas van Panhuys, Ling Zhang, Zhiya Yu, Joseph G Crompton, Jenny H Pan, Douglas C Palmer, Richard A Morgan, Steven A Rosenberg, Nicholas P Restifo
Journal: Molecular Therapy (2013)

Engineering CD8⁺ T cells to deliver interleukin 12 (IL-12) to the tumor site can lead to striking improvements in the ability of adoptively transferred T cells to induce the regression of established murine cancers. We have recently shown that IL-12 triggers an acute inflammatory environment that reverses dysfunctional antigen presentation by myeloid-derived cells within tumors and leads to an increase in the infiltration of adoptively transferred antigen-specific CD8⁺ T cells. Here, we find that local delivery of IL-12 increased the expression of Fas within tumor-infiltrating macrophages, dendritic cells, and myeloid-derived suppressor cells (MDSC), and that these changes were abrogated in mice deficient in IL-12-receptor signaling. Importantly, upregulation of Fas in host mice played a critical role in the proliferation and antitumor activity of adoptively transferred IL-12-modified CD8⁺ T cells. We also observed higher percentages of myeloid-derived cell populations within tumors in Fas-deficient mice, indicating that tumor stromal destruction was dependent on the Fas death receptor. Taken together, these results describe the likely requirement for costimulatory reverse signaling through Fasl on T cells that successfully infiltrate tumors, a mechanism triggered by the induction of Fas expression on myeloid-derived cells by IL-12 and the subsequent collapse of the tumor stroma.
Abstract 164: Impact of an AHA Guideline-Based, Statewide Postarrest System of Care on Survival from Out-of-Hospital Cardiac Arrest
Authors: Ashish R Panchal, Tyler F Vadeboncoeur, Uwe Stolz, Jason R Roosa, Robert A Berg, Gordon A Ewy, Margaret J Mullins, Bentley J Bobrow, Daniel W Spaite
Journal: Circulation (2011)

BACKGROUND: The 2010 American Heart Association (AHA) Guidelines added integrated post-cardiac arrest care as a new 5th link in the classic chain of survival model. In this analysis we: 1) describe...
Lipodystrophia centrifugalis abdominalis infantilis
Authors: Y.C. GIAM, V.S. RAJAN, ONG BENG HOCK
Journal: British Journal of Dermatology (1982)

We describe the first case of lipodystrophia centrifugalis abdominalis infantilis to occur outside Japan. A 7-year-old Chinese boy presented with the classical features, which include the early onset of localized depression of the skin of the abdomen, centrifugal progression of the skin lesion and an erythematous scaling advancing edge. The subcutaneous fat is decreased in the depressed areas.
Comorbidity Status Does Not Independently Predict Survival Outcomes After Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma
Authors: Adrian S. Fairey, Niels-Erik Jacobsen, Eric Estey, Simon Tanguay, Ricardo Rendon, David Bell, Jonathan Izawa, Joseph Chin, Anil Kapoor, Edward Matsumoto, Peter Black, Alan So, Jean-Baptiste Lattouf, Fred Saad, Darrell Drachenberg, Ilias Cagiannos, Louis Lacombe, Yves Fradet, Wassim Kassouf
Journal: European Urology (2013)