Aminoaciduria in an Elderly Man with the Nephrotic Syndrome and in a Young Man with a Variant of the Fanconi Syndrome
Authors: PAUL D. DOOLAN
Journal: Annals of Internal Medicine (1962)

Article1 March 1962Aminoaciduria in an Elderly Man with the Nephrotic Syndrome and in a Young Man with a Variant of the Fanconi SyndromePAUL D. DOOLAN, MANFORD D. MORRIS, PH.D., HAROLD A. HARPER, PH.D.PAUL D. DOOLANSearch for more papers by this author, MANFORD D. MORRIS, PH.D.Search for more papers by this author, HAROLD A. HARPER, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-3-448 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNormally, in a fasting human subject, almost all of the amino acids filtered at the glomerulus are reabsorbed (1). If the filtered load of an amino acid is increased, both the amount reabsorbed as well as that excreted are increased; indeed, in man no clear-cut maximal reabsorptive rate (Tm) has as yet been demonstrated for any amino acid (2). It follows that a major determinant of the amount of an amino acid excreted is the amount filtered, and justification can thus be made for defining an aminoaciduria in terms of the fraction of the filtered load which is excreted. In...References1. DOOLANHARPERHUTCHINSHREEVE PDHAMEWW: Renal clearance of eighteen individual amino acids in human subjects. J. Clin. Invest. 34: 1247, 1955. CrossrefMedlineGoogle Scholar2. DOOLANHARPERHUTCHINALPEN PDHAMEEL: The renal tubular response to amino acid loading. J. Clin. Invest. 35: 888, 1956. CrossrefMedlineGoogle Scholar3. WALLISENGLE LARL: The adult Fanconi syndrome. II. Review of eighteen cases. Amer. J. Med. 22: 13, 1957. CrossrefMedlineGoogle Scholar4. CUSWORTHDENT DCCE: Renal clearances of amino acids in normal adults and in patients with aminoaciduria. Biochem. J. 74: 550, 1960. CrossrefMedlineGoogle Scholar5. ECKHARDTCOOPERFALOONDAVIDSON RDAMWWCS: The urinary excretion of amino acids in man. Trans. N. Y. Acad. Sci. 10: 284, 1948. 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Naval Hospital, Oakland, California.Supported in part by Contract Nonr-222 (51) between the University of California, San Francisco, and the Office of Naval Research, Department of the Navy, Washington, D. C.The opinions or assertions contained herein are the private ones of the authors, and are not to be construed as official or as necessarily reflecting the views of the Medical Department of the Navy or of the Naval Service at large.Requests for reprints should be addressed to the Director, Clinical Investigation Center, U. S. Naval Hospital, Oakland 14, California. 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CURTIS MORRIS JR., M.D.Long-term study of family with Fanconi syndrome without cystinosis (Detoni-Debré-Fanconi syndrome)Medical genetics 1962The Adult Fanconi Syndrome: Report of Two Cases, One with Multiple Myeloma 1 March 1962Volume 56, Issue 3Page: 448-456KeywordsAmino acidsAttentionBlood plasmaElderlyProteinuria Issue Published: 1 March 1962 PDF DownloadLoading ...