tbuckley/cabot-search huggingface dataset:
Teflon and Polytef
Authors: J. M. S. Black
Journal: JAMA (1985)

<h3>To the Editor.—</h3> In the June 22/29, 1984, issue of<i>JAMA</i>, you published an article entitled "Migration and Granulomatous Reaction After Periurethral Injection of Polytef (Teflon)." This is a misuse of Du Pont's trademark "Teflon." "Teflon" is Du Pont's trademark for several products, including fluorocarbon resins, films, and fibers. On the other hand, polytef is a generic term for pharmaceutical compositions of polytetrafluoroethylene and is not a product of the Du Pont Company as might be inferred from the title of this article. We sell no medical grades of "Teflon," and we do not endorse such uses. We have not performed the detailed, long-term studies that should be done before it is used for medical or surgical purposes.
Immunogenicity of Bivalent AC Polysaccharide Meningococcal Vaccine in Children Aged 6 Through 24 Months
Authors: Marc H. Lebel
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trabeculated Right Ventricular Free Wall in the Chicken Heart Forms by Ventricularization of the Myocardium Initially Forming the Outflow Tract
Authors: M. Sameer Rana, Noortje C.A. Horsten, Sabina Tesink-Taekema, Wout H. Lamers, Antoon F.M. Moorman, Maurice J.B. van den Hoff
Journal: Circulation Research (2007)

Recent molecular lineage analyses in mouse have demonstrated that the right ventricle is recruited from anterior mesoderm in later stages of cardiac development. This is in contrast to current views of development in the chicken heart, which suggest that the initial heart tube contains a subset of right ventricular precursors. We investigated the fate of the outflow tract myocardium using immunofluorescent staining of the myocardium, and lineage tracer, as well as cell death experiments. These analyses showed that the outflow tract is initially myocardial in its entirety, increasing in length up to HH24. The outflow tract myocardium, subsequently, shortens as a result of ventricularization, contributing to the trabeculated free wall, as well as the infundibulum, of the right ventricle. During this shortening, the overall length of the outflow tract is maintained because of the formation of a nonmyocardial portion between the distal myocardial border and the pericardial reflections. Cell death and transdifferentiation were found to play a more limited contribution to the initial shortening than is generally appreciated, if they play any part at all. Cell death, nonetheless, plays an important role in the disappearance of the myocardial collar that continues to invest the aorta and pulmonary trunk around HH30, and in the separation of the intrapericardial arterial vessels. Taken together, we show, as opposed to some current beliefs, the development of the arterial pole is similar in mammals and birds.
Derivation and Potential Applications of Human Embryonic Stem Cells
Authors: Lior Gepstein
Journal: Circulation Research (2002)

Embryonic stem cells are pluripotent cell lines that are derived from the blastocyst-stage early mammalian embryo. These unique cells are characterized by their capacity for prolonged undifferentiated proliferation in culture while maintaining the potential to differentiate into derivatives of all three germ layers. During in vitro differentiation, embryonic stem cells can develop into specialized somatic cells, including cardiomyocytes, and have been shown to recapitulate many processes of early embryonic development. The present review describes the derivation and unique properties of the recently described human embryonic stem cells as well as the properties of cardiomyocytes derived using this unique differentiating system. The possible applications of this system in several cardiac research areas, including developmental biology, functional genomics, pharmacological testing, cell therapy, and tissue engineering, are discussed. Because of their combined ability to proliferate indefinitely and to differentiate to mature tissue types, human embryonic stem cells can potentially provide an unlimited supply of cardiomyocytes for cell therapy procedures aiming to regenerate functional myocardium. However, many obstacles must still be overcome on the way to successful clinical utilization of these cells.
In-hospital and one-year outcomes according to ST-segment resolution in high-risk patients with acute myocardial infarction treated with primary angioplasty or thrombolysis: Data from the MISTRAL study
Authors: Giuseppe Steffenino, Claudio Bruna, Guido Rossetti, Antonello Vado, Endrj Menardi, Lucilla Riva, Donata Lucci, Aldo P. Maggioni
Journal: Journal of the American College of Cardiology (2003)
Abstract 4243: Oncogenic K-Ras transforms three-dimensional colon epithelia through upregulation of ERK-MAPK signaling
Authors: Kirti Magudia, Alan Hall
Journal: Cancer Research (2012)

Abstract Colorectal cancers have the third highest incidence and are the second most common cause of cancer-related death when considering tumors that affect both men and women in the United States. Interestingly, a third of these tumors harbor activating mutations in K-Ras and are associated with worse outcomes. Caco-2 cells, derived from a colorectal carcinoma, are noninvasive and do not harbor mutations in K-Ras, B-Raf or PI3KCA. This cell line has historically been used as a model to study normal, differentiated colonic epithelium in two-dimensional cell culture. Recent studies have used Caco-2 cells in a three-dimensional cell culture system to better model epithelial morphogenesis. In this study, we studied the effects of introducing oncogenic K-Ras into three-dimensionally cultured Caco-2 cells. Control Caco-2 cells seeded in extracellular matrix generate hollow, polarized structures after ten days. In contrast, Caco-2 cells expressing oncogenic K-Ras formed much larger and filled structures that lack a central lumen. Furthermore, western blot analysis of protein lysates made from day 1 and day 10 control structures revealed a strong decrease in cyclin B, suggesting a reduction in the proportion of cells undergoing mitosis. K-Ras structures, however, maintained cyclin B levels, providing evidence of prolonged proliferation. In addition, immunofluorescence of the apical marker aPKC and the tight junction protein ZO-1 revealed that K-Ras structures have disrupted polarity. Caco-2 cells expressing oncogenic B-Raf phenocopied our results with oncogenic K-Ras. Conversely, MEK inhibition with U0126 reverted K-Ras structures back to normal morphology, indicating that K-Ras acts through the ERK-MAPK signaling pathway. The expression of active versions of PI3KCA and RalGDS, other Ras effectors, in Caco-2 cells produced structures identical to control. Further work aims to elucidate a more specific mechanism of Ras downstream of the ERK-MAPK signaling pathway in our three-dimensionally cultured Caco-2 system. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4243. doi:1538-7445.AM2012-4243
EUS for unexplained mediastinal lesions
Authors: T. Savides, C. Behling
Journal: Endoscopy (2006)

Trans-esophageal endoscopic ultrasound (EUS) with fine needle aspiration (FNA) offers a unique ability to assess and biopsy posterior mediastinal lesions. This review will focus on EUS diagnosis of unexplained posterior mediastinal, lymph nodes, masses, and cysts. Table [1] shows the types of posterior mediastinal lesions which can be diagnosed with trans-esophageal EUS/FNA cytology.
Bones Metastases (Bm) in Gastric Cancer Patients (Pts): a Monoinstitutional Analysis
Authors: Michela Frisinghelli, Antonello Veccia, Barbara Soini, Sonia Brugnara, Lucianna Maria Russo, Orazio Caffo, Alessia Caldara, Mariachiara Dipasquale, Antonella Ferro, Viviana Murgia, Francesco Valduga, Enzo Galligioni
Journal: Annals of Oncology (2013)
Primary Adenocarcinoma of the Jejunum
Authors: Donald G. Sullivan
Journal: JAMA (1960)

Primary adenocarcinoma of the jejunum is rare. From the literature it becomes eyident that any significant number of these tumors must be gathered from a large clinic over a considerable number of years. However, both of the patients in the cases presented here were operated on within a twomonth period of time. Up to 1929 at the Mayo Clinic there were 55 cases of carcinoma of the small intestine compared to 4,597 of the large intestine and rectum together and 4,335 of the stomach.<sup>1</sup>One-fourth of these carcinomas of the small intestine were in the jejunum. This represents only 0.06% of the carcinomas of the entire gastrointestinal tract. This figure agrees with another series of cases.<sup>2</sup> The average duration of symptoms before diagnosis is 14 months. General weakness, loss of weight, fatigue, and anemia constitute the earlier symptoms. The liquid character of the feces in the small intestine
Study finds possible role for aspirin as treatment for colon cancer
Authors: Z. Kmietowicz
Journal: BMJ (2012)

Researchers are planning to investigate the role of aspirin as a treatment for colon cancer after finding an association with reduced mortality among patients who took the drug after diagnosis.

The use of aspirin as a treatment for colon cancer could prove especially useful for elderly patients who are not suitable for chemotherapy, say the researchers from the Netherlands, whose study is published in the British Journal of Cancer (doi:10.1038/bjc.2012.101).

Previous studies have shown that taking a daily aspirin for several years can help to lower the risk of a number of cancers developing, including bowel and oesophageal cancers. But the present …
Sewage Irrigation: Health Benefit or Hazard?
Authors: DONALD M. MCCLEAN
Journal: Annals of Internal Medicine (1975)

Editorials1 January 1975Sewage Irrigation: Health Benefit or Hazard?DONALD M. MCCLEAN, M.D., F.R.C.P.(C)DONALD M. MCCLEAN, M.D., F.R.C.P.(C)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-1-112 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptQuality of the aquatic environment, especially freshwater lakes and rivers, has become a major issue of public concern during the past decade. Current North American procedures for disposal of effluent, after primary treatment to remove suspended solids, or in some instances after secondary treatment to remove additional solids and reduce biochemical oxygen demand, results in the discharge of huge quantities of fluid rich in nitrogen and phosphorus compounds into lakes and rivers through sewer outfalls. Microbial pathogens, especially viruses, are not regularly inactivated by primary and secondary treatment of sewage (1-4), thereby permitting their discharge with the effluent. This promotes...References1. LAAKMCLEAN RD: Virus transfer through a sewage disposal unit. Can J Public Health 58:172-176, 1967 MedlineGoogle Scholar2. ASKEWBOTTLEACH JRR: Microbiology of reclaimed water from sewage for recreational use. Am J Public Health 55:453-462, 1965 CrossrefGoogle Scholar3. MALHERBESTRICKLAND-CHOMLEY HM: Quantitative studies on viral survival in sewage purification processes, in Transmission of Viruses by the Water Route, edited by BERG G. New York, Interscience Publishers, 1967, pp. 379-387 Google Scholar4. BERG G: Virus transmission by the water vehicle. II. Virus removal by sewage treatment procedures. Health Lab Sci 3:90-100, 1966 MedlineGoogle Scholar5. LAMBCHINSCARCE GTL: Isolation of enteric viruses from sewage and river water in a metropolitan area. Am J Hyg 80:320-327, 1964 MedlineGoogle Scholar6. UDALLSTANSBURY SJ: Sewage: our most neglected resource. Ann Intern Med 81:849-850, 1974 LinkGoogle Scholar7. WOMELDORFWHITESELL DK: Rice field mosquito control studies with low volume Dursban sprays in Colusa County, California. I. Introduction. Mosquito News 32:364-368, 1972 Google Scholar8. FAUSTBEAVERJUNG EPR: Animal Agents and Vectors of Human Disease, 3rd ed. Philadelphia, Lea and Febiger, 1968 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Medical Microbiology University of British Columbia Vancouver Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFate of viruses during wastewater sludge treatment processesSurvival of enteroviruses in rapid-infiltration basins during the land application of wastewater 1 January 1975Volume 82, Issue 1Page: 112-113KeywordsEffluentOxygenPhosphorusRivers ePublished: 1 December 2008 Issue Published: 1 January 1975 PDF downloadLoading ...
TCT-375 Comparison of Long Term Outcome After First- and Second-Generation Drug-Eluting Stents in the Treatment of Chronic Total Occlusions: Insights From a Large Registry of 1,343 Consecutive Patients
Authors: Francesca Sanguineti, Yves Louvard, Stephen O'Connor, Yusuke Watanabe, Carlos J. Garcia Alonso, Thierry Lefevre, Thomas Hovasse, Marie-Claude Morice, Philippe Garot
Journal: Journal of the American College of Cardiology (2013)
Reversible Functional Asplenia
Authors: TSUNEO HIRANO, KATSUMI TOMIYOSHI, HIDENORI TAKE, NAOYUKI WATANABE, NOBORU ORIUCHI, TOMIO INOUE, MASAKO NARUSE, KEIGO ENDO
Journal: Clinical Nuclear Medicine (1994)

An enlarged spleen failed to accumulate Tc-99m-labeled phytate, but it showed normal perfusion and uptake of labeled and heat-denatured red blood cells. A blood cell count demonstrated moderately low hemoglobin and hematocrit levels and a markedly low platelet count, and results of direct Coombs' and antiplatelet-antibody (IgG) tests were positive. Steroid therapy resulted in normal splenic function. This case demonstrates reversible functional asplenia caused by reticuloendothelial dysfunction secondary to pure splenic chronic lymphocytic leukemia.
4 SVR WITH TELAPREVIR, PEGINTERFERON ALFA-2A AND RIBAVIRIN IN HCV PATIENTS WITH WELL-CHARACTERIZED PRIOR NULL RESPONSE, PARTIAL RESPONSE, VIRAL BREAKTHROUGH OR RELAPSE AFTER PR
Authors: T. Berg, J.G. McHutchison, N. Adda, F. Poordad, M.L. Shiffman, P. Ferenci, J. Heathcote, J.-M. Pawlotsky, S. Zeuzem, H. Reesink, G. Dusheiko, E. Martin, D. Alexanderian, S. George, A.J. Muir
Journal: Journal of Hepatology (2010)
NOTE ON THE KEEPING QUALITIES OF THERAPEUTIC SERUMS
Authors: A. T. MacConkey
Journal: BMJ (1917)

Thtree.wounds presenlt over lower part of sternum and one larae ltaceration from which pus poured.lRadiograph on bepteinber 24t1h slio'ved three foreigni-b1odlies-and gas.Mfetal removedl by Mr. 'Hewetsoin.Cutlture from pus showed Icilffits peqyriuge)is.-CASE IX.1 o nbardier lt.Woundedl in left
BRAF<sup>V600E</sup>Protein Expression in Primary Cutaneous Malignant Melanomas and Paired Metastases
Authors: Hanna Eriksson, Abdlsattar Zebary, Ismini Vassilaki, Katarina Omholt, Mehran Ghaderi, Johan Hansson
Journal: JAMA Dermatology (2015)

BRAFV600E mutations are present in approximately 50% of cutaneous malignant melanomas (CMMs). The use of BRAFV600E mutation-specific monoclonal antibody VE1 immunohistochemical analysis may facilitate rapid detection of BRAFV600E mutations in CMMs and demonstrate heterogeneity among tumors.To characterize the pattern of BRAFV600E protein expression in primary CMMs with matched metastases and to analyze the use of VE1 immunohistochemical analysis in clinical practice using formalin-fixed, paraffin-embedded tumor tissue.In this retrospective cohort study performed at Karolinska University Hospital from September 2012 to September 2013, we examined CMMs (124 primary tumors and 76 metastases) with VE1 immunohistochemical analysis, and results were compared with DNA mutation analyses.Determination of intratumoral and intertumoral heterogeneity as well as the sensitivity and specificity of VE1 immunohistochemical analysis.Positive staining results with the VE1 antibody were detected in 94 of 200 tumors (47.0%). In general, VE1 staining was homogeneous. However, VE1 staining intensity varied among the primary tumors and corresponding metastases in 63 of 135 tumors (46.7%), but a change of mutational status based on DNA analysis was found in only 4 matched tumors (3.0%). Discordant findings between DNA mutation analysis and immunohistochemical analysis were observed in 12 tumors. The overall sensitivity and specificity of VE1 immunohistochemical analysis were 96.7% and 94.5%, respectively. A comparable sensitivity was obtained for primary and metastatic CMMs. The specificity was lower among primary CMMs (92.4%) compared with metastases (98.0%).We found VE1 immunohistochemical analysis to be a useful and rapid assay for BRAFV600E mutations that may contribute to the detection of intratumoral and intertumoral heterogenetic subclones. Tumors with positive results, including strong staining, should be expedited for confirmatory BRAF mutation testing. If this test result is negative, a false-negative result of the mutation analysis should be considered. Validation of VE1 immunohistochemical analysis in clinical practice is needed.
Computer Crash — Lessons from a System Failure
Authors: Peter Kilbridge
Journal: New England Journal of Medicine (2003)

Although executives and physicians at the Beth Israel Deaconess Medical Center in Boston have had reason to take great pride in their advanced clinical computing system, they recently had a wake-up call when the system suffered a full-scale failure. Before the crash, the medical center's information-systems staff had designed and implemented a variety of applications to aid clinicians in caring for patients. With this system, clinicians throughout the medical center and the six affiliated CareGroup hospitals can gain access to laboratory results, radiographs, and electrocardiograms electronically, using a secure Internet browser. Patients also have secure access to their test results . . .
Possible clearance of effete polymorphonuclear leucocytes from synovial fluid by cytophagocytic mononuclear cells: implications for pathogenesis and chronicity in inflammatory arthritis.
Authors: S.T Jones, J Denton, P.J Holt, A.J Freemont
Journal: Annals of the Rheumatic Diseases (1993)

A feature common to all forms of chronic inflammatory arthritis, irrespective of the possible underlying cause, is the persistent exudation of large numbers of polymorphonuclear leucocytes (PMNL) into synovial fluid. These cells possess potent degradative enzymes and proinflammatory mediators, and their removal is vital to normal inflammatory resolution. A major route of disposal of extravasated PMNL appears to be programmed cell death (apoptosis), followed by their rapid recognition, and intact phagocytosis, by mature tissue macrophages. Such macrophages, containing PMNL (cytophagocytic mononuclear cells (CPM)), long recognised in synovial fluid as Reiter cells, are commonly found in reactive arthritis, spondyloarthritis, and crystal arthritides, but only rarely in rheumatoid disease. In a retrospective analysis of 187 knee synovial fluid cytospins, the relation between the formation of CPM and the presence of apoptotic (pyknotic) PMNL was investigated. As long as the synovial fluid examined was fresh there was a high correlation between numbers of CPM (as a percentage of macrophages) and pyknotic numbers of PMNL in fluids containing CPM. This suggests that the formation of CPM occurs in vivo and is involved in the disposal of PMNL. Numbers of pyknotic PMNL increased rapidly in stored synovial fluid without a significant change in numbers of CPM, and were highest in synovial fluid which did not contain CPM. The presence or absence of CPM, or their disease associations, could not be explained simply by limiting numbers of macrophages, or apoptotic PMNL in synovial fluid. These findings are consistent with a regulatory role for CPM in synovial fluid, where they may be important in preventing autolysis of PMNL, and thus local tissue damage.
Review of recent studies from central and Eastern Europe associating respiratory health effects with high levels of exposure to "traditional" air pollutants.
Authors: W Jedrychowski
Journal: Environmental Health Perspectives (1995)

The serious environmental problems caused by decades of Communist mismanagement of natural resources in countries of Central and Eastern Europe have been brought to light in recent years. All environmental media, including air, water, food, and soil have been burdened with toxic chemicals. Large segments of the population have been, and are now being exposed to air pollution levels exceeding guidelines established by western countries and by international health organizations. This review focuses on epidemiologic evidence regarding health effects of poor air quality in Central and Eastern Europe. It appears that short-term high levels of air pollutants (primarily particulates and SO2) may increase mortality in sensitive parts of the population. Associations were also seen between air pollution levels and prevalence of respiratory diseases as well as lung function disturbances in adults and children. One study indicated that urban air pollution increased the risk of lung cancer. Several investigations pointed to strong interactions between risk factors. The poor scientific standard of the studies often makes it difficult to evaluate the findings. Several steps should be taken to develop environmental epidemiology in Central and Eastern Europe, including international collaboration in research projects and training.