tbuckley/cabot-search huggingface dataset:
Pianist's cramp to stage fright: the medical side of music-making
Authors: Terra Ziporyn
Journal: JAMA (1984)

Music may soothe the savage breast, but it may not always soothe the musician. The same fingers producing those ethereal tones may be straining painfully as they reach across a string, and the same artistic temperament fiercely striking a chord may have been stricken with nearly incapacitating terror only moments earlier. A handful of physicians, many of whom play instruments themselves or have musical family members, are becoming aware of these unique medical problems. Although the ranks are still too small to call "music medicine" a full-fledged entity akin to sports medicine, communication between musicians and medical practitioners over the past few years is leading to consolidation of isolated experiences into a coherent body of knowledge. Early this summer, for example, Northwestern University in the Chicago suburb of Evanston, Ill, and the American String Teachers Association (ASTA) sponsored a conference on "The String Player's Stress Points—and Their Relief." Here, physicians
Cutaneous Paecilomyces lilacinus infection: Report of two novel cases
Authors: Melanie S. Hecker, Jeffrey M. Weinberg, Bita Bagheri, Ibrahim A. Tangoren, Donald Rudikoff, Edward Bottone, Elise Bilodeau-McCarthy, Robert I. Rudolph, Robert G. Phelps
Journal: Journal of the American Academy of Dermatology (1997)

Paecilomyces species are ubiquitous saprophytic fungi. They usually are recognized as animal and insect pathogens and rarely cause human infection. 1 Rockhill RC Klein MD. Paecilomyces lilacinus as the cause of chronic maxillary sinusitis. J Clin Microbiol. 1980; 11: 737-739 PubMed Google Scholar , 2 Weitzmann I. Saprophytic molds as agents of cutaneous and subcutaneous infection in the immunocompromised host. Arch Dermatol. 1986; 122: 1161-1168 Crossref PubMed Scopus (55) Google Scholar Reports of cutaneous infection are infrequent. 3 Harris LF Dan BM Lefkowitz LB et al. Paecilomyces cellulitis in a renal transplant patient: successful treatment with intravenous miconazole. South Med J. 1979; 72: 897-898 Crossref PubMed Scopus (46) Google Scholar , 4 Jade KB Lyons MF Gnann JW. Paecilomyces lilacinus cellulitis in an immunocompromised patient. Arch Dermatol. 1986; 122: 1169-1170 Crossref PubMed Scopus (49) Google Scholar , 5 Takayasu S Akagi M Shimizu Y. Cutaneous mycosis caused by Paecilomyces lilacinus. Arch Dermatol. 1977; 113: 1687-1688 Crossref PubMed Scopus (58) Google Scholar , 6 Castro LG Salebian A Sotto MN. Hyalohyphomycosis by Paecilomyces lilacinus in a renal transplant patient and a review of human Paecilomyces species infections. J Med Vet Mycol. 1990; 28: 15-26 Crossref PubMed Scopus (110) Google Scholar , 7 Murciano A Domer J Cohen I. Paecilomyces lilacinus infection in an immunocompromised patient. J La State Med Soc. 1990; 142: 35-37 PubMed Google Scholar , 8 Williamson PR Kwon-Chung KJ. Successful treatment of Paecilomyces varioti infection in a patient with chronic granulomatous disease and a review of Paecilomyces species infections. Clin Infect Dis. 1992; 14: 1023-1026 Crossref PubMed Scopus (78) Google Scholar , 9 Silliman CC Lawellin DW Lohr JA et al. Paecilomyces lilacinus infection in a child with chronic granulomatous disease. J Infect. 1992; 24: 191-195 Abstract Full Text PDF PubMed Scopus (42) Google Scholar , 10 Leigheb G Mossini A Boggio P et al. Sporotrichosis-like lesions caused by a Paecilomyces genus fungus. Int J Dermatol. 1994; 33: 275-276 Crossref PubMed Scopus (14) Google Scholar We describe two unusual presentations of human cutaneous infection with Paecilomyces lilacinus.
As good as the next man
Authors: K. Abbasi
Journal: BMJ (2015)

Frustrated by the failings of the NHS, Anthony Grabham entered the “macho” culture of medical politics and quickly became an influential leader, politician, and surgeon. Barbara Castle, a former UK health secretary, called Grabham “the best negotiator I ever dealt with.” Quite a compliment, although tempered by her observation that he was also greedy and arrogant. Richard Smith describes in his obituary this week (doi:10.1136/bmj.h502) how Grabham went on to play a pivotal role as chair of the BMA committee that oversaw the development of the BMJ Publishing Group and The BMJ . When Grabham entered The BMJ ’s offices for his regular meetings with …
Warm blood cardioplegia induces mitochondria- initiated myocyte apoptosis which is ameliorated by overexpression of endogeneous urocortin
Authors: Tiziano M. Scarabelli, Evasio Pasini, Gianna Ferrari, Mario Ferrari, Anastasis Stephanou, Paul Townsend, Kevin Lawrence, Carol chen-Scarabelli, Richard Knight, David Latchman
Journal: Journal of the American College of Cardiology (2003)
Exogenous and endogenous ceramides elicit volume-sensitive chloride current in ventricular myocytes
Authors: Frank J. Raucci, Dayanjan S. Wijesinghe, Charles E. Chalfant, Clive M. Baumgarten
Journal: Cardiovascular Research (2009)

Because ceramide accumulates in several forms of cardiovascular disease and ceramide-induced apoptosis may involve the volume-sensitive Cl− current, ICl,swell, we assessed whether ceramide activates ICl,swell. ICl,swell was measured in rabbit ventricular myocytes by whole-cell patch clamp after isolating anion currents. Exogenous C2-ceramide (C2-Cer), a membrane-permeant short-chain ceramide, elicited an outwardly rectifying Cl− current in both physiological and symmetrical Cl− solutions that was fully inhibited by DCPIB, a specific ICl,swell blocker. In contrast, the metabolically inactive C2-Cer analogue C2-dihydroceramide (C2-H2Cer) failed to activate Cl− current. Bacterial sphingomyelinase (SMase), which generates endogenous long-chain ceramides as was confirmed by tandem mass spectrometry, also elicited an outwardly rectifying Cl− current that was inhibited by DCPIB and tamoxifen, another ICl,swell blocker. Bacterial SMase-induced current was partially reversed by osmotic shrinkage and fully suppressed by ebselen, a scavenger of reactive oxygen species. Outward rectification with physiological and symmetrical Cl− gradients, block by DCPIB and tamoxifen, and volume sensitivity are characteristics that identify ICl,swell. Insensitivity to C2-H2Cer and block by ebselen suggest involvement of ceramide signalling rather than direct lipid-channel interaction. Exogenous and endogenous ceramide elicited ICl,swell in ventricular myocytes. This may contribute to persistent activation of ICl,swell and aspects of altered myocyte function in cardiovascular diseases associated with by ceramide accumulation.
IVF is cost effective up to age 43, says NICE
Authors: Z. Kmietowicz
Journal: BMJ (2012)

Some women aged 40, 41, or 42 should be able to undergo in vitro fertilisation (IVF) treatment on the NHS, says draft guidance from the National Institute for Health and Clinical Excellence.1 The previous upper age limit for IVF funded by the NHS was 39.

The new draft guidance on fertility treatment for NHS bodies in England, Wales, and Northern Ireland updates guidance issued in 2004. It says that women aged 40 to 42 who have not tried fertility treatment before and for whom IVF is the only chance of conceiving should be offered one full cycle of treatment. 

The change in the age limit comes after NICE developed a new economic analysis that for the first time took into account quality adjusted life years (QALYs), cumulative IVF success rates in different clinical settings, single (fresh and frozen) and double embryo transfers, and a …
P4-01-19: SRC-1 Expression Is a Prognostic Factor of Breast Cancer-Specific and Disease-Free Survival in Inflammatory Breast Cancer.
Authors: H Arias-Pulido, RD Ahmed, N Chaher, J Vargas, N Joste, L Lomo, C Qualls, S Azziez, N Terki, K Bouzid, E Prossnitz, M Royce
Journal: Cancer Research (2011)

Abstract Background: Steroid receptor coactivator (SRC-1 to 3) proteins drive nuclear receptor transcriptional activity by modulating transcriptional processes such as chromatin modification, transcription initiation, chain elongation, and RNA splicing. In patients who display resistance to endocrine treatment, SRC-1 has been implicated in the conversion of tamoxifen anti-agonist activity to its agonist profile. SRC-1 expression is a prognostic of DFS in breast cancer, but its role in inflammatory breast cancer (IBC) remains unknown. Materials and Methods: SRC-1 protein levels were measured by immunohistochemistry in 103 IBC and 11 normal, non-cancer related samples, diagnosed at the Centre Pierre &amp; Marie Curie (Algiers, Algeria). Staining results were correlated with protein levels of ER, PR, and HER2, and clinico-pathological variables, breast cancer-specific (BCSS) and disease-free survival (DFS), and response to tamoxifen treatment. Results: SRC-1 was positive in all normal breast tissue, as well as in 66% of IBC samples. SRC-1 positivity was associated with worse OS (P&amp;lt;0.001) and DFS (P=0.004). SRC-1 expression correlated with worse BCSS (P=0.011), and marginally with DFS (P=0.046) in tamoxifen-treated patients, but strongly with DFS (P=0.007) in patients who received no endocrine therapy as indicated by Kaplan-Meier and log-Rank analyses. Multivariate analysis showed that SRC-1 (Hazard Ratios (HR): 5.2; 95%CI: 2.0−13.6; P&amp;lt;0.001) and Her2 (HR: 3.1; 95%CI: 1.2−8.1; P=0.02) expression were independent prognostic markers of BCSS. SRC-1 (HR: 4.8; 95%CI: 1.9−12.2; P&amp;lt;0.001), Her2 (HR: 2.4; 95%CI: 1.0−5.7; P=0.05), and hormone treatment (HR: 0.4; 95%CI: 0.2−0.8; P=0.01) were independent prognostic markers of DFS. Discussion: Determining prognosis and predicting response to endocrine treatment is of paramount importance in the search for personalized treatment. SRC-1 expression predicts worse OS, DFS, and, similar to non-IBC, predicts DFS independently of endocrine therapy. This study highlights the importance of SRC-1 expression as a strong prognosticator of BCSS and disease recurrence in IBC patients. *Supported by an UICC ICRET Fellowship (ICR/09/043 to Dr. Chaher) and by New Mexico State IBC funding (New Mexico Senate Bill 532). Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P4-01-19.
(4) Tricho-rhino-phalangeal syndrome
Authors: S.E. Thomas, J. Mahood, R.E. Church
Journal: British Journal of Dermatology (1986)

Journal Article (4) Tricho‐rhino‐phalangeal syndrome Get access S.E. Thomas, Drs, S.E. Thomas, Drs Search for other works by this author on: Oxford Academic Google Scholar J. Mahood, J. Mahood Search for other works by this author on: Oxford Academic Google Scholar R.E. Church R.E. Church Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue s30, 1 July 1986, Pages 45–47, https://doi.org/10.1111/j.1365-2133.1986.tb07699.x Published: 01 July 1986
Trust, standards and healthcare quality: a case of babies and bathwater?
Authors: Antony Franks, Ian Watt, Phil Ayres, Karen Jones, Colin Pollock, Paula Whitty, John Wright
Journal: Journal of the Royal Society of Medicine (2006)

The last few years have not been too comfortable for the members of many professional groups. Concerns about behaviour, propriety, effectiveness, public safety and, in the case of the public sector, cost have resulted in significant scrutiny of the position and role of professionals. One manifestation of this scrutiny has been a growing tendency to establish and impose external standards of practice embodied in codes of conduct or legislation.

This issue has had its most recent airing in the fifth report of the Shipman Inquiry.1 Historically, the majority of professionals have relied on internally derived and self-managed standards of care; witness the concept of a basic set of `ancient virtues' at the heart of a medical ethos.2 The growing trend of externally imposed standards raises the question as to whether the possible resulting disempowerment will lead to professionals relying less on their intrinsic mechanisms of quality improvement—which, it could be argued, are the mainstay to underpinning safe and effective practice. Are we throwing the baby out with the bathwater?

From the point of view of the patient their long-term interests are likely to be best served by a timely response from the doctor. An internalized professional ethos to act in the patient's best interests would support this. An over reliance on external mechanisms of quality improvement might see professionally derived internal mechanisms atrophy and cease to influence behaviour. In the example of Box 1, a doctor may fail to respond to a patient's vague history of chest pain simply because there are no external drivers to do so. A timely completion of a routine follow-up appointment might be all that the external standards require. The patient may well be satisfied and unaware of the implications of his vague symptoms being passed off. A weakened professional ethos may no longer be able to guide professional practice in those areas where external standards are absent (and perhaps could never even be applied), and hence the quality of patient care would suffer.
Ackerman's Surgical Pathology
Authors: Nancy E. Warner
Journal: JAMA (1997)

" 'Monomania' from Karl Heinrich Baumgärtner's<i>Kranken-Physiognomik</i>(Stuttgart: L. F. Rieger, 1842)." From<i>Seeing the Insane</i>, by Sander L. Gilman, 252 pp, with illus, paper, $30, ISBN 0-8032-7064-X, Lincoln, Neb, University of Nebraska Press, 1982, 1996. The publication of the eighth edition of<i>Ackerman's Surgical Pathology</i>, the third under the aegis of Juan Rosai, is a welcome event for surgical pathologists. Since the last edition in 1989, the field of surgical pathology has continued to expand at an exponential rate. To reflect these advances, the new edition has been completely revised and updated. Dr Rosai again has succeeded in condensing the new information into a concise but comprehensive and readable text, maintaining the standard of excellence and uniformly high quality he achieved in the two prior editions. Six collaborators have written on the following subjects: Drs K. W. Barwick (liver—nonneoplastic diseases), N. G. Ordóñez (kidney—nonneoplastic diseases), R. D. Brunning (bone marrow),
Should Physicians Treat Patients Who Seek Second Opinions?-Reply
Authors: Michael L. Ile
Journal: JAMA (1991)

<h3>In Reply.</h3> —Several professions, including medicine, have in the past adopted ethical rules that were found by the courts to be unduly restrictive of competition, and therefore unlawful. Simply put, the medical profession must maintain an ethical code that does not violate the antitrust laws. This does not mean that physicians are required by law to behave unethically. For example, as Dr Cohen correctly points out, many physicians do not wish to treat patients who seek second opinions. This position is both ethical and lawful. The antitrust laws merely mandate that each physician reach this decision independently, for it is also appropriate ethically and lawfully for physicians to treat patients who seek second opinions. The Supreme Court has unequivocally decided that the medical profession and its ethical rules are subject to the Sherman Act. My article attempted to show that the profession can maintain strong ethical principles that are consistent
Tyrosine hydroxylase is expressed during early heart development and is required for cardiac chamber formation
Authors: Carmen López-Sánchez, Óscar Bártulos, Enrique Martínez-Campos, Carlos Gañán, Ana I. Valenciano, Virginio García-Martínez, Flora De Pablo, Catalina Hernández-Sánchez
Journal: Cardiovascular Research (2010)

Tyrosine hydroxylase (TH) is the first and rate-limiting enzyme in catecholamine biosynthesis. Whereas the neuroendocrine roles of cathecolamines postnatally are well known, the presence and function of TH in organogenesis is unclear. The aim of this study was to define the expression of TH during cardiac development and to unravel the role it may play in heart formation. We studied TH expression in chick embryos by whole mount in situ hybridization and by quantitative reverse transcription-polymerase chain reaction and analysed TH activity by high-performance liquid chromatography. We used gain- and loss-of-function models to characterize the role of TH in early cardiogenesis. We found that TH expression was enriched in the cardiac field of gastrulating chick embryos. By stage 8, TH mRNA was restricted to the splanchnic mesoderm of both endocardial tubes and was subsequently expressed predominantly in the myocardial layer of the atrial segment. Overexpression of TH led to increased atrial myosin heavy chain (AMHC1) and T-box 5 gene (Tbx5) expression in the ventricular region and induced bradyarrhythmia. Similarly, addition of l-3,4-dihydroxyphenylalanine (l-DOPA) or dopamine induced ectopic expression of cardiac transcription factors (cNkx2.5, Tbx5) and AMHC1 as well as sarcomere formation. Conversely, blockage of dopamine biosynthesis and loss of TH activity decreased AMHC1 and Tbx5 expression, whereas exposure to retinoic acid (RA) induced TH expression in parallel to that of AMHC1 and Tbx5. Concordantly, inhibition of endogenous RA synthesis decreased TH expression as well as that of AMHC1 and Tbx5. TH is expressed in a dynamic pattern during the primitive heart tube formation. TH induces cardiac differentiation in vivo and it is a key regulator of the heart patterning, conferring atriogenic identity.
Promotion of Micrometastasis Proliferation in a Rat Rhabdomyosarcoma Model by Epidermal Growth Factor
Authors: F. Breillout, E. Antoine, V. Lascaux, Y. Rolland, M. -F. Poupon
Journal: JNCI Journal of the National Cancer Institute (1989)

Using a rat rhabdomyosarcoma 9-4/0, we investigated the role of epidermal growth factor (EGF) in tumor dissemination. In vitro, we detected high-affinity EGF receptors on tumor cells and stimulation of their proliferation by EGF. When injected iv, EGF-pretreated cells demonstrated an increased capacity to form lung colonies and to invade lymphatic tissue. In vivo, EGF treatment led to increased metastatic spread of subcutaneous tumors. When primary tumors were ablated, and the treatment was given from the time of graft until ablation (seeding step), no effect on metastatic spread was noticed. When treatment was given from the time of ablation until death (growth step), EGF increased the number of lung metastases and of invaded lymph node sites. (J Natl Cancer Inst 81:702–705, 1989)
Eye protection in psoralen photochemotherapy
Authors: J.B. DAVEY, B.L. DIFFEY, J.A. MILLER
Journal: British Journal of Dermatology (1981)

The optical performance of some commercially-available tinted lenses is discussed. There is a wide variation in the UV absorbing power of sunglasses although adequate protection against solar UV-A can be achieved with some, but not all, polarizing material. The darkness of a tint is not an indication of its likely performance within the ultraviolet bands and it is possible that lenses could be produced that lacked any significant tint yet absorbed strongly throughout the UV region.
Ouabain increases the calcium concentration in intracellular stores involved in stimulus-response coupling in human platelets.
Authors: P Roevens, D de Chaffoy de Courcelles
Journal: Circulation Research (1990)

The effect of ouabain on Ca2+ homeostasis in human platelets was studied using both quin 2 and chlorotetracycline to monitor changes in cytosolic Ca2+ as well as changes in the amount of Ca2+ accumulated in intracellular storage sites. In resting platelets, ouabain induces a concentration- and time-dependent increase in cytosolic Ca2+ concentration and a marked elevation of Ca2+ in the intracellular stores. The amount of Ca2+ mobilized from these stores upon stimulation with thrombin, as well as thrombin-induced secretion of platelet 5-hydroxytryptamine, was increased after preincubation with the glycoside (3 x 10(-6) M). These data show that ouabain induces an elevation of intracellular Ca2+ levels, most likely mediated via Na(+)-Ca2+ exchange, and that this incremental amount of Ca2+ is accumulated in an intracellular store involved in stimulus-response coupling. This may explain the enhanced functional responses of platelets to agonists in the presence of ouabain and suggests a role for Na(+)-Ca2+ exchange in Ca2+ homeostasis of the human platelet.
Nuclear Threat: What About the Russians?
Authors: John Nernoff
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The SPECIAL COMMUNICATIONS section of the Aug 2 issue, summed up in Dr Lundberg's editorial<sup>1</sup>as "Prescriptions for Peace in the Nuclear Age," in addition to reiterating standard leftist peace formulas, also contains some surprising instances of ignorance and gullibility. Noteworthy is Dr Dimond's<sup>2</sup>goofy proposal of an involuntary exchange of hostages between the US and the USSR. Amazingly, he ignores or is simply unaware of the Soviet Union's largely bloody history, from the more than 6 million Ukrainians starved to death by Stalin's forced collectivization in the 1930s (a holocaust given little press these days) to their latest perverse obliteration of human rights activism (just in time for the tenth anniversary of the Helsinki accords). There are quite a bit more bloody tramplings in between that seem to escape Dr Dimond's febrile imagination. In view of this horrifying Soviet record, can one be even slightly
Former UN envoy attacks UNAIDS for its “catatonic passivity”
Authors: Zosia Kmietowicz
Journal: BMJ (2007)

The former United Nations special envoy for AIDS in Africa has issued a scathing condemnation of UNAIDS (the joint UN and World Health Organization programme on HIV and AIDS) for its “catatonic passivity” in the face of the epidemic. He has also delivered a blistering criticism of the agency's latest report on prevalence.

Stephen Lewis, who worked for the UN for more than two decades, holding the post of special envoy between 2001 and 2006, attacked UNAIDS for “delaying and dithering” in producing revised figures on the prevalence of HIV and AIDS. He said the resulting report, the 2007 AIDS Epidemic Update , had served to divert the world's attention away from the “continuing apocalypse for sub-Saharan Africa” by focusing instead on the mathematical models and reasons for the adjusted figures.

The report, which was released last week (bmj.com, 24 Nov, News Extra doi: 10.1136/bmj.39406.611273.DB), showed that UNAIDS had overestimated the scale of the epidemic in 2007 and that the number of people with HIV or AIDS was 33 million rather than the 40 million it had …
The deletion genotype of the angiotensin I-converting enzyme is associated with an increased vascular reactivity in vivo and in vitro
Authors: Daniel Henrion, Joelle Benessiano, Ivan Philip, Sandrine Vuillaumier-Barrot, Marc Iglarz, Gaetan Plantefève, Didier Chatel, Ulrich Hvass, Geneviève Durand, Jean-Marie Desmonts, Philippe Amouyel, Bernard I Lévy
Journal: Journal of the American College of Cardiology (1999)
Five Probiotic Drops a Day to Keep Infantile Colic Away?
Authors: Bruno P. Chumpitazi, Robert J. Shulman
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal