tbuckley/cabot-search huggingface dataset:
Peanut Lectin: A Mitogen for Normal Human Colonic Epithelium and Human HT29 Colorectal Cancer Cells
Authors: S. D. Ryder, J. A. Smith, J. M. Rhodes
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Peanut Lectin: A Mitogen for Normal Human Colonic Epithelium and Human HT29 Colorectal Cancer Cells Get access Stephen D. Ryder, Stephen D. Ryder Department of Medicine, University of LiverpoolEngland Search for other works by this author on: Oxford Academic PubMed Google Scholar John A. Smith, John A. Smith Department of Biochemistry, University of LiverpoolEngland Search for other works by this author on: Oxford Academic PubMed Google Scholar Jonathan M. Rhodes Jonathan M. Rhodes * Department of Medicine, University of LiverpoolEngland *Correspondence to : Jonathan M. Rhodes, M.A., M.D., F.R.C.P., Department of Medicine, University of Liverpool, P.O. Box 147, Liverpool L69 3BX, England. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 18, 16 September 1992, Pages 1410–1416, https://doi.org/10.1093/jnci/84.18.1410 Published: 16 September 1992 Article history Received: 23 September 1991 Revision received: 08 June 1992 Accepted: 11 June 1992 Published: 16 September 1992
Basophil histamine release in the diagnosis of house dust mite and dander allergy of asthmatic children
Authors: P. A. ØStergaard, F. Ebbesen, H. Nolte, P. Stahl Skov
Journal: Allergy (1990)

The aim of the study is to compare the glass fibre‐based basophil histamine release test with skin test (Phazet®), RAST (Phadebas®) and bronchial provocation test in children with allergic asthma. The study comprised 68 selected children with a case history of extrinsic allergic asthma to danders (cat and dog) and house‐dust mite. Skin prick test, RAST, and histamine release were performed in all children and the bronchial provocation test was used as a reference of “true allergic asthma”. A total of 81 allergen bronchial challenges were performed and 44 children experienced 49 positive provocations. In 2.9% (2/68) of the children histamine release could not be performed due to technical difficulties (low histamine release with anti‐IgE). Concordances in the range 76–87 % were observed with no significant difference between the tests. The highest concordance (87%) was found between histamine release and bronchial provocation test followed by skin prick test vs bronchial provocation (84 %) and RAST vs bronchial provocation (80%). The sensitivity and specificity were calculated for each test. All tests showed sensitivities in the range 90–94 % and no significant difference between them was observed. The specificity of histamine release, skin prick test, and RAST was 0.78, 0.69, and 0.63, respectively. The specificity of histamine release was better than RAST demonstrated by 95% confidence intervals. In conclusion, it was found that the histamine release test is a convenient diagnostic method and the study indicates a diagnostic value comparable to the common diagnostic methods in clinical allergy.
"Dangerous Recipients" of Transfusion
Authors: G. H. Tovey, C. P. Warren, E. E. Wood
Journal: BMJ (1953)

MEDICAL JOURNA.L81 should be carried out in order to determine the dosage of the drug required and the length of its administration in the treatment of the abscess.Minor toxic symptoms were observed.The drug can be safely used as a therapeutic test if diagnosis is doubtful.My grateful thanks are due to the Dean of the King Edward
Pulmonary vascular responses to forebrain stimulation in the cat.
Authors: A L Hyman, C W Dempesy, C Fontana, D E Richardson, R W Rieck, P J Kadowitz
Journal: Circulation Research (1988)

The effects of forebrain stimulation on the pulmonary vascular bed were investigated in the intact-chest cat under conditions of controlled blood flow and constant left atrial pressure. When pulmonary vascular tone was raised to a high steady level, direct electrical stimulation of the forebrain elicited a biphasic change in lobar arterial pressure. The response was characterized by an initial transient increase in lobar arterial pressure that was followed by a prolonged secondary decrease in pressure. When a delay coil was added to the extracorporeal perfusion circuit, the secondary vasodilator response was separated into initial brief and delayed prolonged components, suggesting that it was mediated in part by the release of a humoral factor. The entire response to forebrain stimulation was abolished by cervical cord section or freezing. The initial constrictor response and early brief dilator response were not blocked by classic pharmacological blocking agents. The delayed humorally mediated vasodilator response was blocked by propranolol or ICI 118551, indicating that it was mediated by a circulating factor with beta 2-stimulating properties. The delayed vasodilator response was associated with a large increase in arterial epinephrine levels, and this rise in plasma epinephrine was not altered by propranolol. The present data suggest that electrical stimulation of the forebrain causes a prolonged pulmonary vasodilator response that is mediated by way of a descending pathway, which results in a large rise in arterial epinephrine levels.
Senior pharmaceutical figure calls on industry to improve its image
Authors: O. Ellis
Journal: BMJ (2010)

The former medical director of the drug company Wyeth UK has called on the industry to improve its reputation among doctors and to get more involved in training them.

David Gillen, who is now head of international medical affairs at Gilead Sciences, told the annual symposium last week of the Faculty of Pharmaceutical Medicine of the Royal Colleges of Physicians of the UK that academia, the NHS, and the drug industry should collaborate more.

“Trust needs to happen again,” he said. “Fundamentally most of us in this room represent industry, and fundamentally most of us …
Anaphylactic Reaction Following the Oral Administration of Penicillin
Authors: Leonard P. Lang, Henry Clagett
Journal: New England Journal of Medicine (1955)

THE administration of penicillin may be followed by anaphylactic reactions. Severe reactions are not unusual after topical and parenteral administration but are rare after oral administration.Welch and his co-workers1 surveyed antibiotic reactions in 95 general hospitals (51,000 bed capacity). They found 1 fatal reaction after the oral ingestion of 1 tablet of dibenzylethylenediaminedipenicillin (Bicillin). They were aware of 1 other anaphylactic reaction to penicillin by mouth.Eisenstadter and Hussar2 reported the case of a twenty-two-year-old woman who manifested abdominal cramps, itching, pain in the hands, cold sweat and urinary incontinence ten minutes after the ingestion of 1 tablet of . . .
Chronic monotherapy with extended release metoprolol succinate attenuates mRNA gene expression of brain and atrial natriuretic peptides in left ventricular myocardium of dogs with heart failure
Authors: Sharad Rastogi, Ramesh C. Gupta, Sudhish Mishra, Hideaki Morita, George Suzuki, Sidney Goldstein, Hani N. Sabbah
Journal: Journal of the American College of Cardiology (2003)
Reimbursement for Patient and Family Meetings and the Costs of Care at the End of Life
Authors: Stephen A. Hilty
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Is there a component of coronary collateral flow which cannot be detected by radiolabelled microspheres?
Authors: M. P MAXWELL, D. J HEARSE, D. M YELLON
Journal: Cardiovascular Research (1987)

The possibility of a component of collateral flow to the ischaemic myocardium that cannot be detected by the radiolabelled microsphere technique was examined in the cat, rat, and rabbit in vivo. Animals were anaesthetised and a coronary artery ligated. The regional distribution of blood flow was assessed by the simultaneous injection of 141Ce labelled microspheres and 86Rb. Blue dye was injected into the circulation to delineate the perfused tissue and the heart removed, frozen, and lyophilised, after which tissue was separated into ischaemic and non-ischaemic fractions and the radioactivity of each assessed. Flow to the ischaemic zone, expressed as a percentage of that in the non-ischaemic tissue, for 86Rb based assessments and 141Ce measurements was: for the cat 21.6(3.9)% and 12.4(1.4)% (n=12 hearts); the rat 13.2(2.6)% and 5.2(1.8)% (n=9); and the rabbit 7.2(0.8)% and 1.9(0.8)% (n=5) respectively. In all species there was a statistically significant difference (p<0.01) between the results for the two markers. These results suggest either a microsphere insensitive component of collateral flow or some methodological inadequacy of one of the assessment techniques. The 86Rb data were corrected for possible artefacts due to the flow rate dependent extraction of the isotope. The new 86Rb values for collateral flow in the cat, rat, and rabbit were 15.2(2.9)% (NS vs microspheres), 9.5(1.9)% (p<0.05), and 5.2(0.5)% (p<0.05) respectively. Although these values were closer to the 141Ce microsphere values, significant differences between the two results still remained, possibly owing to other limitations of the 86Rb method. In an attempt to overcome this, additional studies were carried out with 3H desmethylimipramine (DMI), a marker of flow with more complete uptake characteristics than 86Rb. This was examined in the in vitro rabbit heart with regional ischaemia. Collateral flow, as a percentage of the radioactivity in the non-ischaemic myocardium, was 1.9(0.4)% for 3H desmethylimipramine and 1.1(0.3)% for 141Ce labelled microspheres (n=5 hearts; NS). In conclusion, these results do not support the concept of a biologically significant microsphere insensitive component of collateral flow.
Core–shell cell bodies composed of human cbMSCs and HUVECs for functional vasculogenesis
Authors: Wen-Yu Lee, Hung-Wen Tsai, Jen-Hao Chiang, Shiaw-Min Hwang, Ding-Yuan Chen, Li-Wen Hsu, Yi-Wen Hung, Yen Chang, Hsing-Wen Sung
Journal: Biomaterials (2011)
Amiodarone and Torsade de Pointes
Authors: Tsung O. Cheng
Journal: Annals of Internal Medicine (1995)

Letters1 April 1995Amiodarone and Torsade de PointesTsung O. ChengTsung O. ChengSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-7-199504010-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:No sooner had I finished reading the convincing review by Hohnloser and associates [1], who argued against the importance of amiodarone-associated proarrhythmic effects, than I read an equally persuasive article expressing a diametrically opposed view in another journal published at the same time [2]. The former article [1] concluded that the “low arrhythmogenicity and the negligible negative inotropic effect. make amiodarone particularly useful in treating high-risk patients (with coronary artery disease) prone to sudden cardiac death (due to torsade de pointes tachycardia),” whereas the latter concluded that “amiodarone therapy should be withheld in patients with ventricular tachycardia ...References1. Hohnloser SH, Klingenheben T, Singh BN. Amiodarone-associated proarrhythmic effects. A review with special reference to torasade de pointes tachycardia. Ann Intern Med. 1994; 121:529-35. Google Scholar2. Mickleborough LL, Maruyama H, Mohamed S, Rappaport DC, Downar E, Butany J, et al. Are patients receiving amiodarone at increased risk for cardiac operations? Ann Thorac Surg. 1994; 58:622-9. Google Scholar3. Cheng TO. Acronyms of clinical trials in cardiology—1994. Am J Cardiol. 1994; 74:79-94. Google Scholar Author, Article, and Disclosure InformationAuthors: Tsung O. Cheng PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1995Volume 122, Issue 7 Page: 553-554 Keywords Atrial fibrillation Health care Heart failure Mortality Myocardial infarction Patients Stable coronary artery disease Sudden cardiac death Tachycardia Ventricular tachycardia ePublished: 15 August 2000 Issue Published: 1 April 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
IL-4 Upregulates FceRI-Mediated TSLP Expression by Human Mast Cells
Authors: Y. Okayama, H. Sagara, S. Okumura, K. Yuki, T. Fukuda, H. Saito
Journal: Journal of Allergy and Clinical Immunology (2007)

RATIONALE: Since mast cells (MCs) within the bronchial mucosa expressing mRNA for thymic stromal lymphopoietin (TSLP) was reported to be significantly increased in asthmatics as compared with controls, we examined TSLP protein expression mechanisms in bronchial mucosa of asthmatics and in human cultured MCs. METHODS: We used dual staining with anti-TSLP Ab and cell-type specific Ab to determine the population of cells expressing TSLP in the lungs of 16 patients with asthma and of 11 control patients. We examined TSLP expression by human MCs in vitro using RT-PCR, FACS and ELISA. RESULTS: Ninety % of TSLP+ cells in protein levels were MCs in bronchial mucosa in asthmatics and the number of TSLP+ MCs was significantly increased in the airways of asthmatic patients (p < 0.0001). There were a significant correlation between the percentage of TSLP+ MCs, and serum IgE level (p < 0.05, r2 = 0.0528), suggesting that IgE-mediated activation produce TSLP in MCs. However, FcɛRI-mediated activation of human cultured MCs upregulated TSLP mRNA expression only 5.2 ± 2.9 fold. IL-4 significantly enhanced FcɛRI-mediated TSLP mRNA expression (53.7 ± 15.9 fold, n = 3). We found the presence of TSLP in the cell pellets but not in the supernatants from activated MCs. This was due to rapid degradation of TSLP by MC protease. FACS analysis revealed that the intensity of TSLP immunostaining was upregulated in monensin-treated MCs following activation. CONCLUSIONS: Increased expression of TSLP in MCs of bronchial mucosa in asthmatics would be due to significant upregulation of FcɛRI-mediated TSLP expression by IL-4.
HER-2/<i>neu</i> Serum Levels Vis-à-Vis Hormonal Response in Metastatic Breast Cancer
Authors: Lawrence C. Panasci, A. Lipton, S.M. Ali, K. Leitzel, L. Engle, V. Chinchilli
Journal: Journal of Clinical Oncology (2002)

Article Tools SPECIAL DEPARTMENTS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2002.99.002 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12149314 HER-2/neu Serum Levels Vis-à-Vis Hormonal Response in Metastatic Breast Cancer Lawrence C. PanascixLawrence C. PanasciSearch for articles by this author A. LiptonxA. LiptonSearch for articles by this author , S.M. AlixS.M. AliSearch for articles by this author , K. LeitzelxK. LeitzelSearch for articles by this author , L. EnglexL. EngleSearch for articles by this author , V. ChinchillixV. ChinchilliSearch for articles by this author Show More Jewish General Hospital, McGill University, Montreal, QuebecPenn State College of Medicine Hershey, PA https://doi.org/10.1200/JCO.2002.99.002 First Page Full Text PDF Figures and Tables © 2002 by American Society of Clinical OncologyjcoJ Clin OncolJournal of Clinical OncologyJCO0732-183X1527-7755American Society of Clinical OncologyResponse01082002In Reply:In response to Dr Panasci’s question, we have performed a 2 × 2 χ2 analysis and a multivariate analysis within the two strata of visceral disease and nonvisceral disease. Based on the χ2 tests, clinical benefit (complete response + partial response + stable) within each stratum was significantly less for serum HER-2/neu elevated versus serum HER-2/neu normal patients (P = .0001 and P = .0011, respectively). Likewise, based on the multivariate analyses, serum HER-2/neu remained a significant prognostic factor for response to therapy within the two strata (P = .0005 and P = .002, respectively).
The use of injectable sonication-induced silk hydrogel for VEGF165 and BMP-2 delivery for elevation of the maxillary sinus floor
Authors: Wenjie Zhang, Xiuli Wang, Shaoyi Wang, Jun Zhao, Lianyi Xu, Chao Zhu, Deliang Zeng, Jake Chen, Zhiyuan Zhang, David L. Kaplan, Xinquan Jiang
Journal: Biomaterials (2011)
Preventing deep vein thrombosis in hospital inpatients
Authors: William E Cayley
Journal: BMJ (2007)

#### Summary points

Most hospital inpatients are at risk of deep vein thrombosis (DVT) and the associated complications of fatal or non-fatal pulmonary embolism and post-thrombotic syndrome. Recognised risk factors for DVT are generally related to one or more elements of Virchow's triad (stasis, vessel injury, and hypercoagulability), and include surgery, trauma, immobilisation, malignancy, use of oestrogens, heart or respiratory failure, and smoking (box 1).1 Surveillance studies have found that the absolute risk of DVT is 10%-20% among general medical patients and up to 40%-80% in patients having hip surgery, knee surgery, or major trauma (table⇓).1

View this table:

 
Absolute risk of deep vein thrombosis in hospital inpatients 



#### Box 1 Risk factors for deep vein thrombosis (adapted from Geerts et al1)

##### Stasis

##### Vessel injury

##### Hypercoagulability

It is difficult to predict …
THE COMPLEMENT FIXATION REACTION AS APPLIED TO LEPROSY
Authors: Paul A. Lewis, Joseph D. Aronson
Journal: The Journal of Experimental Medicine (1923)

By means of a method differing in important details from those of previous investigators it has been determined that the blood serum of cases of leprosy exhibits the ability to fix complement with a wide variety of antigens including to a greater or less extent those derived from any culture of the acid-fast group of bacteria available to us. This property of multiple fixation may sufficiently characterize the disease to be of diagnostic significance, although our experience is hardly sufficient to enable us to speak with complete assurance on this point. Certainly, control sera from normal individuals, from cases of tuberculosis, or from cases of syphilis as obtained in our locality have entirely failed to react with certain antigens, whereas serum from cases of leprosy have so reacted to the extent of over 93 per cent. The most characteristic fixation given by the leprosy sera is that with Bacillus lepræ (Clegg) used as antigen, either in the form of a bacterial emulsion or of an alcoholic extract of the dried culture. Antibody absorption may be demonstrated in the acid-fast group if the absorbing bacteria are removed by filtration. Otherwise the resulting fluid is strongly anticomplementary. Leper serum is not deprived of the complement-fixing body when so treated with either Bacillus tuberculosis or Bacillus lepræ (Clegg).
THE ANTIBACTERIAL PROPERTIES OF SULFUR
Authors: Julia T. Weld, Anne Gunther
Journal: The Journal of Experimental Medicine (1947)

1. Saturated solutions of sulfur in alcohol (alcohol-sulfur) when diluted with broth are inhibitory to the growth of various Gram-positive bacteria and to C. hominis. By an arbitrary method of unitage with S. aureus as the test organism, our alcohol-sulfur contains 1,600 to 2,000 units per cc. and one unit contains between 0.24 and 0.34 gamma sulfur. The activity of a preparation is in general directly proportional to its sulfur content. 2. Solutions of sulfur in carbowax (carbowax-sulfur) when diluted with broth are likewise inhibitory to the growth of various Gram-positive bacteria and to C. hominis. When S. aureus is used as test organism, 1 unit contains between 0.1 and 0.2 gamma sulfur. The activity of these preparations is also in general directly proportional to their sulfur content. 3. Carbowax-sulfur when incorporated in agar in 1–500 to 1–2,000 dilution inhibits the growth of various Gram-positive aerobic and anaerobic bacteria, C. hominis, and certain dermatophytes. 4. Our experiments appear to show that both alcohol-sulfur and carbowax-sulfur owe their inhibitory properties to the sulfur particles that are dispersed throughout the medium when these sulfur preparations are diluted with broth. The inhibitory effect of these particles may or may not be due to a combination of the sulfur particles with substances in the medium in which they are suspended. 5. Evidence suggests that the activity of both alcohol-sulfur and carbowax-sulfur is due to sulfur in the same form. The inhibitory effect is characterized by prolonged bacteriostasis with similar activity over a wide range of dilutions. There is no evidence of true bactericidal action even with the highest concentrations used.
Blood or Urine Glucose-Based Insulin Therapy and Control of Glycemia: Computer-Simulation Study
Authors: A M Albisser, S Sozzi, T R Strack
Journal: Diabetes Care (1990)

Adjustment algorithms for conventional insulin therapy must be tested for safety and efficacy before clinical implementation. We did this by computer simulation. Accordingly, a computer simulator of human intermediary metabolism created 10 randomly chosen diabetic subjects for study. All were well defined with respect to compliance (i.e., medication and diet) and life-style (i.e., physical and emotional stress). Insulinadjustment algorithms that were tested calculated daily insulin dosages for these computer-simulated patients based on either blood or urine glucose concentrations self-measured 4 times/day before breakfast, lunch, dinner, and bedtime snack. The twofold purpose of the simulation study was to determine the ability of the adjustment algorithms to improve initially poor metabolic control and to compare the outcomes when either blood or urine glucose measurements were the basis on which glycemic control was implemented. A significant improvement in metabolic control could be achieved with either blood or urine glucose measurements as input to the algorithms. Detailed comparisons between blood and urine glucose-based treatments showed no significant advantage of blood glucose-based algorithms at breakfast (122 ± 21 vs. 131 ± 16 mg/dl) and dinner (117 ± 27 vs. 130 ± 23 mg/dl), whereas mean glycemia at lunch (122 ± 24 vs. 164 ± 21 mg/dl) and bedtime (117 ± 25 vs. 150 ± 21 mg/dl) after 120 days of simulation did differ significantly (P &amp;lt; 0.01). Hypoglycemia was not provoked by either treatment. Total daily insulin doses evolved by blood glucose-based algorithms were significantly (P &amp;lt; 0.05) higher than the doses used by urine glucose-based algorithms (53 vs. 47 U). We conclude that either blood or urine glucose-based insulin-adjustment algorithms that we devised promise to achieve improved glycemic control with only minor differences between the two. Clinical studies can now safely be conducted.
Magnetic resonance cholangiopancreatography in the diagnosis of primary sclerosing cholangitis
Authors: C. Weber, R. Kuhlencordt, R. Grotelueschen, U. Wedegaertner, T. Ang, G. Adam, N. Soehendra, U. Seitz
Journal: Endoscopy (2008)

See also: Commentaire de travail de C. Weber et al., pp. 739Endoscopy 2008; 40(09): 968-969DOI: 10.1055/s-0032-1306874