tbuckley/cabot-search huggingface dataset:
Simultaneous conductance catheter and dimension assessment of left ventricle volume in the intact animal.
Authors: R J Applegate, C P Cheng, W C Little
Journal: Circulation (1990)

We compared left ventricle (LV) volume (V) simultaneously measured using the conductance catheter (VM) with volume calculated from three LV dimensions (VD) determined ultrasonically from endocardial crystals. Seven adult mongrel dogs (20-30 kg) were anesthetized and instrumented to measure micromanometer LV pressure and V. Three pairs of crystals were placed orthogonally in subendocardial positions and a conductance catheter was placed in the LV retrograde across the aortic valve. Under steady-state conditions, over the range of a single cardiac cycle, the relation between VM and VD was well described by a straight line. There was an excellent correlation of conductance and dimension volumes with r equal to 0.97 +/- 0.04 and SEE 0.8 +/- 0.5 ml. The gain (1/alpha) and parallel conductance volume (alpha VC) were constant. At lower volumes obtained during bicaval occlusion, however, the relation between VM and VD was curvilinear. 1/alpha and alpha VC both decreased as LVV fell. Thus, determination of absolute volume using the conductance catheter depended on the conditions under which the data were obtained. Under steady-state conditions, alpha VC calculated by both the saline method (mean +/- SD, 50 +/- 15 ml) and by regression of VM and VD, (45 +/- 21 ml) were similar. Consequently, absolute LV end-diastolic volumes and end-systolic volumes by the conductance and dimension methods were similar (53 +/- 14 ml and 38 +/- 14 ml vs. 56 +/- 17 ml and 44 +/- 16 ml, respectively, p = NS). When volume decreased during bicaval occlusion, there was a progressively greater decrease in VM as compared with VD. The absolute slope (EES) of the end-systolic pressure-volume relation (ESPVR) was consistently higher by the dimension method, group average, 16.3 +/- 7.6, than by the catheter, 8.5 +/- 5.9, p less than 0.05. The direction and magnitude of the change in EES at different inotropic states (autonomic blockade; dobutamine), however, was similarly measured by both the conductance catheter and dimension method. We conclude that the gain and offset of the conductance catheter are relatively constant at steady state but vary when volume is reduced by caval occlusion. Thus, the conductance catheter accurately measures absolute volumes at steady state but can underestimate the slope and position of the ESPVR when it is determined by caval occlusion. The conductance catheter does, however, accurately measure the directions and magnitude of change in contractile state.
Case 47-1981
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Robert H. Ackerman, Edward P. Richardson
Journal: New England Journal of Medicine (1981)

Presentation of CaseA 63-year-old woman was admitted to the hospital because of left hemiparesis.She was well until six months previously, when she noticed an enlarging mass in front of the right ear, followed by the onset of pain in that ear. She also became aware of an ulcerated lesion at the tip of the nose but was uncertain of its duration. Four days before admission she entered another hospital.There was a history of a partial gastrectomy for a duodenal ulcer 15 years earlier. Ten years before entry a vagotomy was performed after an episode of hematemesis. She . . .
Low Exhaled Nitric Oxide in School-Age Children with Bronchopulmonary Dysplasia and Airflow Limitation
Authors: Eugenio Baraldi, Gea Bonetto, Franco Zacchello, Marco Filippone
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

Bronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, may be associated with long-term airflow limitation. Survivors of BPD may develop asthma-like symptoms in childhood, with a variable response to beta(2)-agonists. However, the pathologic pathways underlying these respiratory manifestations are still unknown. The aim of this study was to measure exhaled nitric oxide (FE(NO)) and lung function in a group of 31 school-age survivors of BPD. They showed variable degrees of airflow obstruction (mean FEV(1) 77.8 +/- 2.3% predicted) unresponsive to beta(2)-agonists in 72% of the subjects. Their FE(NO) values (geometric mean [95% confidence interval]: 7.7 [+/- 1.1] ppb) were significantly lower than in a group of healthy matched control subjects born at term (10.7 [+/- 1.1] ppb, p < 0.05) and a group of preterm children without BPD (9.9 [+/- 1.1] ppb, p < 0.05). The children with BPD were also compared with a group of 31 patients with asthma with a comparable airflow limitation (FEV(1) 80.2 +/- 2.1% predicted) and showed FE(NO) values four times lower than in those with asthma (24.9 [+/- 1.2] ppb, p < 0.001). In conclusion, unlike children with asthma, school-age survivors of BPD have airflow limitation associated with low FE(NO) values and lack of reversibility to beta(2)-agonists, probably as a result of mechanisms related to early life structural changes in the airways.
Ruptured pseudoaneurysm of the splenic artery complicating endoscopic ultrasound-guided fine-needle aspiration biopsy for pancreatic cancer
Authors: K. Matsumoto, K. Hara, A. Sawaki, N. Mizuno, S. Hijioka, H. Imamura, Y. Niwa, M. Tajika, H. Kawai, S. Kondo, Y. Inaba, K. Yamao
Journal: Endoscopy (2010)

Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is a safe procedure, although major complications do rarely occur. Pseudoaneurysm rupture is an emergency that can cause life-threatening hemorrhage. An exceedingly rare case of ruptured pseudoaneurysm of the splenic artery following EUS-FNA is described.
Potential value of automated daily screening of cardiac resynchronization therapy defibrillator diagnostics for prediction of major cardiovascular events: results from Home‐CARE (Home Monitoring in Cardiac Resynchronization Therapy) study
Authors: Stefan Sack, Christian Michael Wende, Herbert Nägele, Amos Katz, Wolfgang Rudolf Bauer, Craig Scott Barr, Klaus Malinowski, Harald Schwacke, Francisco Leyva, Jochen Proff, Sergey Berdyshev, Vincent Paul
Journal: European Journal of Heart Failure (2011)

To investigate whether diagnostic data from implanted cardiac resynchronization therapy defibrillators (CRT-Ds) retrieved automatically at 24 h intervals via a Home Monitoring function can enable dynamic prediction of cardiovascular hospitalization and death.Three hundred and seventy-seven heart failure patients received CRT-Ds with Home Monitoring option. Data on all deaths and hospitalizations due to cardiovascular reasons and Home Monitoring data were collected prospectively during 1-year follow-up to develop a predictive algorithm with a predefined specificity of 99.5%. Seven parameters were included in the algorithm: mean heart rate over 24 h, heart rate at rest, patient activity, frequency of ventricular extrasystoles, atrial-atrial intervals (heart rate variability), right ventricular pacing impedance, and painless shock impedance. The algorithm was developed using a 25-day monitoring window ending 3 days before hospitalization or death. While the retrospective sensitivities of the individual parameters ranged from 23.6 to 50.0%, the combination of all parameters was 65.4% sensitive in detecting cardiovascular hospitalizations and deaths with 99.5% specificity (corresponding to 1.83 false-positive detections per patient-year of follow-up). The estimated relative risk of an event was 7.15-fold higher after a positive predictor finding than after a negative predictor finding.We developed an automated algorithm for dynamic prediction of cardiovascular events in patients treated with CRT-D devices capable of daily transmission of their diagnostic data via Home Monitoring. This tool may increase patients' quality of life and reduce morbidity, mortality, and health economic burden, it now warrants prospective studies. ClinicalTrials.gov NCT00376116.
Cimetidine and the gastric mucosal barrier.
Authors: G S Kenyon, I F Ansell, D C Carter
Journal: Gut (1977)

The histamine H2-receptor antagonist, cimetidine, when given topically or parenterally, did not affect net luminal Na+ gain or net luminal H+ loss in vagally-denervated pouches of antrectomised dogs. Cimetidine did not affect disruption of the mucosal barrier by 5 mmol/l or 20 mmol/l sodium taurocholate.
P154 The Impact Of A Discharge Care Bundle On The 30-day Readmission Rate Following Hospitalisation For Acute Copd Exacerbation
Authors: J. Seymour, D. Nedelcu
Journal: Thorax (2014)

<h3>Introduction</h3> National audit reports high rates of early readmission following hospitalisation for chronic obstructive pulmonary disease (COPD) exacerbation. Discharge bundles aim to optimise care and reduce readmission. Frimley Park Hospital NHS Foundation Trust interacts with different community respiratory teams across three counties. <h3>Aims</h3> We hypothesised that a novel COPD discharge bundle would reduce re-admission. We also wished to see if the bundle was effective across multiple community administrations, and in patients with a history of frequent exacerbation. <h3>Methods</h3> Admissions with a primary COPD diagnostic code and cases referred to the COPD nurse were collated during Q4 2013/14. Patients were classified according to whether they were assessed by the COPD nurse using the discharge bundle. Readmissions within 30-days and 3-months were identified using a hospital clinical database. Readmissions with COPD exacerbation (infective or non-infective) were included, as well as COPD associated lower respiratory tract infection or pneumonia. The database identified frequent severe exacerbators (patients with &gt;1 admission in the previous year), and recorded age and length of stay as surrogates of disease complexity. <h3>Results</h3> 24 patients were excluded (18 had other diagnoses, 4 died, and 2 lived out of area). Table 1 shows the characteristics of the remaining 156 patients according to whether they completed the bundle. There was no overrepresentation of short (zero or one day) length of stay patients in the group not completing the bundle. 17.5% of patients completing the bundle were re-admitted within 30-days, compared to 34% who did not (p = 0.027). A similar trend was seen at 3-months. No difference was observed in the timing or duration of readmissions. Logistic regression using covariates of age, length of stay, history of frequent severe exacerbation and discharge bundle use, suggested the latter two variables were both independent predictors of re-admission at 30-days: OR 5.70 (95% CI 2.46 to 13.2, p &lt; 0.001) and OR 0.33 (95% CI 0.14 to 0.79, p = 0.012) respectively. Different community teams exerted no significant effect when added to the model. <h3>Discussion</h3> Two-thirds of patients completed a discharge bundle during the Trust's busiest quarter for COPD admission. Patients completing the discharge bundle had a significantly lower rate of 30-day readmission.
Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells
Authors: Matthias Peipp, Jeroen J. Lammerts van Bueren, Tanja Schneider-Merck, Wim W. K. Bleeker, Michael Dechant, Thomas Beyer, Roland Repp, Patrick H. C. van Berkel, Tom Vink, Jan G. J. van de Winkel, Paul W. H. I. Parren, Thomas Valerius
Journal: Blood (2008)

Glycosylation of the antibody Fc fragment is essential for Fc receptor-mediated activity. Carbohydrate heterogeneity is known to modulate the activity of effector cells in the blood, in which fucosylation particularly affects NK cell-mediated killing. Here, we investigated how the glycosylation profile of 2F8, a human IgG(1) monoclonal antibody against epidermal growth factor receptor in clinical development, impacted effector function. Various 2F8 batches differing in fucosylation, galactosylation, and sialylation of the complex-type oligosaccharides in the Fc fragment were investigated. Our results confirmed that low fucose levels enhance mononuclear cell-mediated antibody-mediated cellular cytotoxicity (ADCC). In contrast, polymorphonuclear cells were found to preferentially kill via high-fucosylated antibody. Whole blood ADCC assays, containing both types of effector cells, revealed little differences in tumor cell killing between both batches. Significantly, however, high-fucose antibody induced superior ADCC in blood from granulocyte colony-stimulating factor-primed donors containing higher numbers of activated polymorphonuclear cells. In conclusion, our data demonstrated for the first time that lack of fucose does not generally increase the ADCC activity of therapeutic antibodies and that the impact of Fc glycosylation on ADCC is critically dependent on the recruited effector cell type.
L-Dopa and Behavior
Authors: Barry I. Liskow
Journal: JAMA (1972)

Levodopa (L-dopa) has proved valuable both as a therapeutic and research tool. Its therapeutic usefulness, as is well known, rests with its treatment of Parkinson's disease, and only recently has hope been kindled for its usefulness in the treatment of psychiatric disorders. This hope grew out of the side effects noted in treating Parkinson patients—the lifting of depression, increased motor activation and alertness, and increased libido and alleviation of impotence. Unfortunately, the evidence now available and summarized in this short book indicates that levodopa is without effect in depression, tends to worsen preexisting psychosis, activates latent hypomania, is essentially useless in treating impotence, and can lead to toxic delirium, agitation and perhaps temporary psychosis. The therapeutic side effects of levodopa in Parkinson's disease are evidently secondary to the psychological benefits accruing from improvement of a chronic disorder. Levodopa's other value, as a research tool, is covered less extensively although touched
Treatment of the Neuroleptic Malignant Syndrome With Bromocriptine
Authors: Suhayl Dhib-Jalbut, Roger Hesselbrock, Thomas Brott
Journal: JAMA (1983)

<h3>To the Editor.—</h3> We read the article of Mueller et al reporting successful treatment of the neuroleptic malignant syndrome (NMS) with bromocriptine mesylate (1983;249:386). At the time this article appeared, we were in the process of evaluating the effect of bromocriptine in a patient with features of the NMS, who eventually responded favorably. <h3>Report of a Case.—</h3> A 48-year-old chronic schizophrenic receiving treatment with monthly 1.5-mL (37.5-mg) intramuscular injections of fluphenazine deconoate was admitted to the hospital on Dec 24, 1982, because of nausea, vomiting, and generalized seizures. The family stated that the patient was consuming large amounts of water and complaining of thirst before his admission. The patient had a temperature of 35.5 °C, BP of 140/72 mm Hg, a regular pulse rate of 80 beats per minute, and respirations of 20/min. The remainder of the general physical examination results were unremarkable. The neurologic examination results were remarkable for
Effects of naloxone on pethidine-induced neonatal depression. Part II--Intramuscular naloxone.
Authors: P C Wiener, M I Hogg, M Rosen
Journal: BMJ (1977)

Thirty full-term infants whose mothers had had pethidine during labour were given either naloxone 200 microgram or normal saline intramuscularly. The drugs were chosen blindly and administered within one minute of birth. Naloxone produced a significant reduction in mean alveolar carbon dioxide tension and an increase in carbon dioxide excretion and mean alveolar ventilation at all times up to 48 hours after birth. The mean rate of habituation to a repeated auditory stimulus, the mean sucking frequency, the sucking pressure, and the mean consumption of milk were all significantly higher in the naloxone-treated group than in the placebo-treated group up to 48 hours after birth. Intramuscular naxolone therefore seemed to reverse the undesirable effects of pethidine.
A Direct Comparison of Early and Late Outcomes With Three Approaches to Carotid Revascularization and Open Heart Surgery
Authors: Mehdi H Shishehbor, Sridhar Venkatachalam, Zhiyuan Sun, Jeevanantham Rajeswaran, Samir R Kapadia, Christopher Bajzer, Heather L Gornik, Bruce H Gray, John R Bartholomew, Daniel G Clair, Joseph F Sabik, Eugene H Blackstone
Journal: Journal of the American College of Cardiology (2013)
Was it wrong to want a baby?
Authors: A. Cobb
Journal: BMJ (1995)

Some months ago we failed in our fourth and last attempt to have a child using ovum donation and in vitro fertilisation. I am 61. With my first husband, in my late 20s, I had had three children in four years. We later separated and then divorced. Twenty years ago, when the youngest was 12, I fell in love with a wonderful man. At 47, he is 14 years younger than me. He has no children.

Unsure that love with such a big age gap could last, it was at least five years before we asked a fertility clinic why I did not get pregnant. We paid for a sperm test and laparoscopy, which indicated nothing wrong except that at 47, I was probably too old. Later that year, accepting that we would never have a child together, we got married and lived happily in various remote places in Africa.

Eleven years after that, back in England, one of my children, now a doctor and a mother, told us that a woman of 60 in Italy had had a baby. We questioned ourselves all over again. Was I so old now that I could not bring up a baby? Were we selfish? Would it be teased? Would it wish it had never been born? Surely not. I would, I hoped, be there for most of its …
Nicotine Mediated Release of Myocardial Cell and Lysosomal Enzymes.
Authors: Norman Brachfeld
Journal: Annals of Internal Medicine (1967)

s1 May 1967Nicotine Mediated Release of Myocardial Cell and Lysosomal Enzymes.Norman Brachfeld, M.D., F.A.C.P., Peter Kuehn, M.D., Masaka Kawade, M.D., Erdogan Oran, M.D.Norman Brachfeld, M.D., F.A.C.P.Search for more papers by this author, Peter Kuehn, M.D.Search for more papers by this author, Masaka Kawade, M.D.Search for more papers by this author, Erdogan Oran, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1034_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMechanisms responsible for the documented cardiotoxicity of nicotine are unknown and are complicated by the diverse effects of this complex agent. It has been shown to release catecholamines from ganglia and from stores and to stimulate release of antidiuretic hormone. In the brain, nicotine toxicity may be expressed as an interference with cellular respiratory metabolism. Experiments were designed to dissect its diffuse activity and to evaluate its primary hemodynamic and cardiometabolic actions at low and elevated dose levels on the isolated, perfused, beating rat heart. Effects on lysosomal, mitochondrial, and supernatant enzyme systems of the myocardium were studied. There was... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1967Volume 66, Issue 5Page: 1034-1034KeywordsAntidiuretic hormoneBrainCatecholaminesEnzymesGangliaHeartHemodynamicsMyocardiumNicotineToxicity Issue Published: 1 May 1967 PDF DownloadLoading ...
CORONARY COMPUTED TOMOGRAPHY ANGIOGRAPHY AND WHOLE GENOME SEQUENCING AS AN APPROACH TO DISCOVER THE GENETIC BASIS OF DISEASE IN A FAMILY PRONE TO MYOCARDIAL INFARCTION
Authors: Pradeep Natarajan, Nathan Stitziel, Maros Ferencik, Lindsey Hildebrand, Namrata Gupta, Stacey Gabriel, Udo Hoffmann, Sekar Kathiresan
Journal: Journal of the American College of Cardiology (2014)
Abstract LB-435: Double-blind randomized clinical trial of vitamin D3 showing effects on tissue calcitriol levels, gene expression and proliferation immunohistochemistry in prostate cancer
Authors: Dennis Wagner, Larisa Nonn, Angeline Antonio, Avani Vaishnav, Laurence Klotz, Neil Fleshner, Antonio Finelli, Dominique Trudel, Theodorus van der Kwast, Reinhold Vieth
Journal: Cancer Research (2012)

Abstract Background: Preclinical data suggest that vitamin D plays a favourable role in prostate cancer prevention and prognosis, but its putative anticancer effects have not been validated in clinical prostate tissue samples. Here, we report the results from a randomized clinical trial (RCT). Objectives: We conducted an RCT to determine whether simple cholecalciferol (vitamin D3) consumed orally elicits effects on prostate cancer pathology in prostate tissue obtained at surgery. Methods: Prostate cancer patients (n=66) with Gleason scores 6 or 7 and scheduled for radical prostatectomy were randomized to daily vitamin D doses of 400, 10,000, or 40,000 IU for 3-8 wk before surgery. Results: Laser-capture microdissected paraffin-embedded prostate tissue showed differential expression, between benign and cancerous regions, for the cancer-related mRNAs and miRNAs, as well as for the Ki-67 proliferation marker (p0.07 among groups). The group consuming 40,000 IU/d vitamin D exhibited the highest levels of both calcitriol and its precursor as measured in frozen prostate tissue and in serum (p&amp;lt;0.02 each). Prostate tissue calcitriol correlated strongly with the expression of androgen receptor mRNA (r = -0.58, p=0.001), NKX3.1 mRNA (r = -0.39, p=0.02), miR-100 (r = 0.44, p=0.01), miR-125b (r = 0.37, p=0.03), Let-7a (r = 0.47, p=0.03), miR-141 (r = 0.51, p=0.002), miR-106b (r = 0.45, p=0.01), and miR-331-3p (r = 0.47, p=0.005). Automated digital analysis of immunohistochemically stained prostate cancer regions showed that prostate tissue calcitriol related negatively with Ki67 intensity (r = -0.38, p =0.02) and percent of nuclei stained strongly positive (3+) for Ki67 (r = -0.41, p=0.008). A threshold effect was evident such that patients at the highest quartile of prostate tissue calcitriol (≥ 37 pmol/kg) had significantly lower AR mRNA (p&amp;lt;0.001), NKX3.1 mRNA (p=0.01), and Ki67 measures (p&amp;lt;0.05), as well as higher levels of the correlated miRNAs (p&amp;lt;0.05), compared to those with lower levels. Conclusions: We provide level-1 clinical evidence that higher oral vitamin D doses produce higher levels of calcitriol within prostate tissue, and that higher prostate calcitriol relates to lower androgen receptor mRNA, higher miRNA signalling, and diminished expression of the proliferation marker Ki67 in prostate cancer. These RCT results justify a need to explore strategies that may maximize calcitriol within prostate for cancer chemoprevention. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-435. doi:1538-7445.AM2012-LB-435