tbuckley/cabot-search huggingface dataset:
Abstract 4584: Pre-clinical studies of a novel antibody to treat pancreatic and colorectal cancers
Authors: Andrew Bristol, Judith Kantor, Janos Luka, Joe Stafford, Rishab Gupta, Philip Arlen
Journal: Cancer Research (2011)

Abstract Introduction: NPC-1C is a chimeric monoclonal antibody being developed as a novel biological treatment for pancreatic and colorectal cancers. NPC-1C appears to recognize a variant form of MUC5AC expressed specifically by human pancreatic and colorectal tumor tissues and cell lines. Here we show pre-clinical studies in preparation for testing this therapeutic for a Phase I clinical trial. Methods: The NPC-1C antibody was selected from a panel of hybridomas generated from mice immunized with semi-purified membrane-associated proteins derived from biologically screened, pooled human allogeneic colon cancer tissues. In vitro assays and in vivo studies were performed to characterize the GMP-grade antibody. Results: Here we show that NPC-1C reacts with colorectal and pancreatic tumor tissues, but does not cross-react with normal human tissues, except for occasional, weak binding to certain GI tract tissues, which may indicate a pre-malignant state. The NPC-1C antibody exhibits cell-specific binding and ADCC activity against human colorectal and pancreatic tumor cells, but not against control tumor cell lines. In vivo, the anti-tumor efficacy of NPC-1C was tested using pre-established subcutaneous human tumor xenograft models. The data showed significant, and reproducible, anti-tumor action, including some complete tumor regressions. The pre-clinical toxicity profile of NPC-1C in normal BALB/c mice demonstrated little, if any, toxicity following single or multiple intravenous injections. The bio-distribution of radiolabeled NPC-1C in mice with pre-established human tumors revealed specific accumulation of NPC-1C at the tumor site, with little or no binding or accumulation in several major organ systems. Finally, the cytokine and antibody responses to NPC-1C were studied in the pre-clinical mouse model. Although anti-NPC-1C antibodies were detected (as expected) in a time-dependent fashion, there were no changes detect in Type I and Type II cytokines either 3 days or 14 days after intravenous administration. Conclusions: The pre-clinical development of NPC-1C indicates that it is safe and efficacious, and suggests that it may have clinical activity in patients whose tumor expresses the variant MUC5AC epitope. The potential clinical application for this antibody was bolstered by showing approximately 50-70% of human pancreatic and colon tumor tissues stained positively with NPC-1C. The therapeutic antibody is now being tested in a Phase I clinical trial in patients with advanced pancreatic and colorectal cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4584. doi:10.1158/1538-7445.AM2011-4584
Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance
Authors: Laurence Menard, Tineke Cantaert, Nicolas Chamberlain, Stuart G. Tangye, Sean Riminton, Joseph A. Church, Amy Klion, Charlotte Cunningham-Rundles, Kim E. Nichols, Eric Meffre
Journal: Journal of Allergy and Clinical Immunology (2013)
Economic Assessment of Platelet Glycoprotein IIb/IIIa Inhibition for Prevention of Ischemic Complications of High-Risk Coronary Angioplasty
Authors: Daniel B. Mark, J. David Talley, Eric J. Topol, Lee Bowman, Lai Choi Lam, Keaven M. Anderson, James G. Jollis, Michael W. Cleman, Kerry L. Lee, Thomas Aversano, William J. Untereker, Linda Davidson-Ray, Robert M. Califf
Journal: Circulation (1996)

In the EPIC trial, c7E3 Fab, an antiplatelet IIb/ IIIa receptor antibody, reduced 30-day ischemic end points after high-risk coronary angioplasty by 35% and 6-month ischemic events by 23% but increased in-hospital bleeding episodes.Of the 2099 patients randomized in EPIC, data were collected on 2038 (97%) for prospective hospital cost and major resources. Physician fees were estimated from the Medicare Fee Schedule. Regression analysis was used to examine the economic tradeoff between reduced ischemic events and increased major bleeding during the initial hospitalization. A potential cost savings of $622 per patient during the initial hospitalization from reduced acute ischemic events with c7E3 Fab was offset by an equivalent rise ($521) in costs as the result of an increase in bleeding episodes. Baseline medical costs for the bolus and infusion c7E3 Fab arm averaged $13,577 (exclusive of drug cost) compared with $13,434 for placebo (P = .42). During the 6-month follow-up, c7E3 Fab decreased repeat hospitalization rates by 23% (P = .004) and repeat revascularization by 22% (P = .04), producing a mean $1270 savings per patient (exclusive of drug cost) (P = .018). With a cost of $1407 for the bolus and infusion c7E3 Fab regimen, the cumulative net 6-month cost to switch from standard care to routine c7E3 Fab averaged $293 per patient.In high-risk coronary angioplasty, aggressive platelet inhibition with c7E3 Fab, by significantly reducing ischemic events and repeat revascularization, recoups most of the cost of therapy and has the potential to pay for itself.
IL-12 in conjunction with dendritic cells enhances antiviral CD8+ CTL responses in vitro.
Authors: N Bhardwaj, R A Seder, A Reddy, M V Feldman
Journal: Journal of Clinical Investigation (1996)

CD8+ cytolytic T lymphocytes (CTLs) are important mediators for resistance to infections and malignant diseases. IL-12 enhances proliferative and cytolytic responses by killer cells, but its function in the generation of human antiviral CD8+ T cell responses has not been defined. We therefore evaluated the role of IL-12 in the generation of CTLs to influenza-infected dendritic cells. IL-12 was not detectable in supernatants of infected-dendritic cells, or during CTL generation. Furthermore, anti-IL-12 antibody did not block CTL generation. However, exogenous IL-12 (30-300 pg/ml) enhanced CD8+ T cell proliferative and cytolytic responses. The effect was greatest in individuals with weak reactivity to influenza virus or at antigen-presenting cell (APC):T cell ratios of 1:100 or less. IL-12 augmented interferon-gamma production during CTL generation. The CTL enhancing effects of the cytokine, however, could not be blocked by neutralizing anti-interferon-gamma antibody. Together with IL-12, antigen-pulsed dendritic cells may be a useful approach for boosting CTL responses against infectious agents and malignancies.
Aspirin Use and Risk for Colorectal Adenoma
Authors: Henry Scovern
Journal: Annals of Internal Medicine (2004)

Letters7 September 2004Aspirin Use and Risk for Colorectal AdenomaHenry Scovern, MDHenry Scovern, MDFrom Wyomissing, PA 19610.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-5-200409070-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In Chan and colleagues' article on aspirin use and risk for colorectal adenoma (1), it was unclear to me how short-term and long-term use were tabulated and how aspirin use was related to the subsequent endoscopy event. Was short-term defined as use for no more than the 5 years immediately preceding endoscopy or as any cumulative use up to and including 5 years at any point before endoscopy? Did the 5 years of use have to be consecutive? Did the authors' analysis of data suggest that 5 years of aspirin use at any point in time was ...Reference1. Chan AT, Giovannucci EL, Schernhammer ES, Colditz GA, Hunter DJ, Willett WC, et al . A prospective study of aspirin use and the risk for colorectal adenoma. Ann Intern Med. 2004;140:157-66. [PMID: 14757613] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Wyomissing, PA 19610. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Prospective Study of Aspirin Use and the Risk for Colorectal Adenoma Andrew T. Chan , Edward L. Giovannucci , Eva S. Schernhammer , Graham A. Colditz , David J. Hunter , Walter C. Willett , and Charles S. Fuchs Aspirin Use and Risk for Colorectal Adenoma Andrew T. Chan and Charles S. Fuchs Metrics 7 September 2004Volume 141, Issue 5Page: 406KeywordsAdenomasAspirinEndoscopy ePublished: 7 September 2004 Issue Published: 7 September 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Caffeine Intake and the Risk of First-Trimester Spontaneous Abortion
Authors: Sven Cnattingius, Lisa B. Signorello, Göran Annerén, Britt Clausson, Anders Ekbom, Elisabeth Ljunger, William J. Blot, Joseph K. McLaughlin, Gunnar Petersson, Anders Rane, Fredrik Granath
Journal: New England Journal of Medicine (2000)

Some epidemiologic studies have suggested that the ingestion of caffeine increases the risk of spontaneous abortion, but the results have been inconsistent.We performed a population-based, case-control study of early spontaneous abortion in Uppsala County, Sweden. The subjects were 562 women who had spontaneous abortion at 6 to 12 completed weeks of gestation (the case patients) and 953 women who did not have spontaneous abortion and were matched to the case patients according to the week of gestation (controls). Information on the ingestion of caffeine was obtained from in-person interviews. Plasma cotinine was measured as an indicator of cigarette smoking, and fetal karyotypes were determined from tissue samples. Multivariate analysis was used to estimate the relative risks associated with caffeine ingestion after adjustment for smoking and symptoms of pregnancy such as nausea, vomiting, and tiredness.Among nonsmokers, more spontaneous abortions occurred in women who ingested at least 100 mg of caffeine per day than in women who ingested less than 100 mg per day, with the increase in risk related to the amount ingested (100 to 299 mg per day: odds ratio, 1.3; 95 percent confidence interval, 0.9 to 1.8; 300 to 499 mg per day: odds ratio, 1.4; 95 percent confidence interval, 0.9 to 2.0; and 500 mg or more per day: odds ratio, 2.2; 95 percent confidence interval, 1.3 to 3.8). Among smokers, caffeine ingestion was not associated with an excess risk of spontaneous abortion. When the analyses were stratified according to the results of karyotyping, the ingestion of moderate or high levels of caffeine was found to be associated with an excess risk of spontaneous abortion when the fetus had a normal or unknown karyotype but not when the fetal karyotype was abnormal.The ingestion of caffeine may increase the risk of an early spontaneous abortion among non-smoking women carrying fetuses with normal karyotypes.
Stanford Indirect-Cost Investigations Weigh Heavy on University Research
Authors: C. Vanchieri
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Stanford Indirect-Cost Investigations Weigh Heavy on University Research Get access Cori Vanchieri Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 24, 19 December 1990, Pages 1870–1871, https://doi.org/10.1093/jnci/82.24.1870 Published: 19 December 1990
Suppression of phagocytic cells in retinal disorders using amphiphilic poly(γ-glutamic acid) nanoparticles containing dexamethasone
Authors: Morin Ryu, Toru Nakazawa, Takami Akagi, Tatsuhide Tanaka, Ryou Watanabe, Masayuki Yasuda, Noriko Himori, Kazuichi Maruyama, Toshihide Yamashita, Toshiaki Abe, Mitsuru Akashi, Kohji Nishida
Journal: Journal of Controlled Release (2010)
Returning Pleiotropic Results From Genetic Testing to Patients and Research Participants
Authors: Jonathan M. Kocarnik, Stephanie M. Fullerton
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Closing the Chapter on Maharishi Ayur-Veda
Authors: Charles N. Alexander
Journal: JAMA (1992)

<h3>To the Editor.</h3> —I feel compelled to respond to three paragraphs on page 1749 in the Maharishi Ayur-Veda story<sup>1</sup>inaccurately portraying my work. First, on page 1749, the article says that in a meeting of transcendental meditation (TM) representatives with Arizona Department of Corrections (ADC) officials, "it was made clear the Arizona Department of Corrections was not interested in their proposal." This was not the case. The then commissioner expressed a clear interest in this proposal and indeed discussed using TM with a particular group of intractable, violent offenders detained in a special high-security facility. He asked us to submit a further proposal specifically targeted for that group. Second, the article reports that I said TM was the "only" effective way of rehabilitating prisoners. Although I did say that TM was distinctively effective in prison rehabilitation, I did<i>not</i>say it was the only way. Indeed, I suggested it
THE PASSAGE OF METHYLENE BLUE FROM THE MATERNAL TO THE FETAL CIRCULATION.
Authors: S. H. CORRIGAN
Journal: JAMA (1907)

Failure to find record of any similar observation in the study of placento-maternal circulation would seem sufficient reason for submitting the following: A woman, three months pregnant, suffering much from a chronic cystitis, was given a capsule of methylene blue compound. As the medicine produced almost complete relief of symptoms, the patient continued taking it up to the time of her delivery, at full term. The average dosage given her was three grains of the methylene blue daily. At delivery the baby, an unusually vigorous child, attracted no special attention, but when the nurse was removing the first diaper she noticed a blue stain on the cotton; each subsequent change of diaper during the first eighty hours after birth gave evidence of methylene blue in the infant's urine, the color gradually disappearing. Nothing else unusual was found in the baby's condition. It was noticed that the liquor amnii showed no
The evolution of neural dynamics permitting isocortical-limbic-motor communication
Authors: R. Hermer-Vazquez, L. Hermer-Vazquez
Journal: Behavioral and Brain Sciences (2003)

The first cortically based associative circuits integrated olfactory, motivational, and motor information. Many of the neural dynamics present in these evolutionarily ancient, olfactory-motor circuits, such as the broadband frequency, phase, and amplitude modulations seen during recognition of a rewarded olfactory stimulus, are also found in isocortical circuits. These results suggest that mechanisms permitting olfactory associative processing formed the basis for evolutionarily more recent large-scale couplings involving isocortical areas.
Abstract 2106: Estrogen receptor alpha drives proliferation of prostate cancer through PI3K and MAPK signaling
Authors: Itsuhiro Takizawa, Mitchell Lawrence, Helen Pearson, John Pedersen, Normand Pouliot, Patrick Humbert, Luc Furic, Gail Risbridger
Journal: Cancer Research (2014)

Abstract Prostate cancer, a hormone-dependent disease of aging men, occurs as the relative levels of estrogen compared to testosterone are increasing. Indeed, high doses of estrogen, in combination with androgens, can initiate prostate cancer. This effect is attributed to the activity of the estrogen receptor α (ERα), but a paucity of suitable models means that the precise role of ERα in prostate cancer is still poorly understood. In this study we observed increased ERα expression in three different models of prostate cancer, PTEN null mice, Hi-Myc mice, and high grade human tumor specimens. Within the PTEN null prostate, there was a consistent pattern of ERα expression: low in benign glands, moderate in tumors within the dorsal, lateral and ventral lobes, and high in tumors within the anterior prostate. This pattern significantly correlated with the levels of the proliferative marker Ki67. There was also a significant correlation between ERα and Ki67 within individual malignant glands in the anterior prostate. Furthermore, we demonstrated that ERα sustained the in vitro proliferation of cells derived from a PTEN null tumor in 2D and 3D assays. There was a significant decrease in proliferation in cells treated with TPSF, a non-competitive ERα antagonist, or with ERα-specific shRNA. Loss of ERα caused a significant decrease in the levels of MYC and other ERα target genes. It also reduced the activity of both the PI3K and MAPK pathways as measured by decreased levels of phosphorylated erk1/2, S6 kinase and other downstream factors. This effect was reversed in rescue experiments with expression constructs for both full length ERα, capable of genomic and non-genomic actions, and membrane-only ERα, only able to trigger rapid non-genomic signalling. Collectively, these results demonstrate that ERα levels increase in prostate cancer, which promotes proliferation through classical genomic and rapid non-genomic signalling. Citation Format: Itsuhiro Takizawa, Mitchell Lawrence, Helen Pearson, John Pedersen, Normand Pouliot, Australian Prostate Cancer BioResource, Patrick Humbert, Luc Furic, Gail Risbridger. Estrogen receptor alpha drives proliferation of prostate cancer through PI3K and MAPK signaling. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2106. doi:10.1158/1538-7445.AM2014-2106
Inducible Myocardial Ischemia and Outcomes in Patients With Coronary Artery Disease and Left Ventricular Dysfunction
Authors: Julio A. Panza, Thomas A. Holly, Federico M. Asch, Lilin She, Patricia A. Pellikka, Eric J. Velazquez, Kerry L. Lee, Salvador Borges-Neto, Pedro S. Farsky, Robert H. Jones, Daniel S. Berman, Robert O. Bonow
Journal: Journal of the American College of Cardiology (2013)
Radiological evidence of femoroacetabular impingement in asymptomatic athletes
Authors: J Abellàn, F Esparza, A Blanco, M Martínez, G Ruiz Merino, A Lisón
Journal: British Journal of Sports Medicine (2011)

Background Femoroacetabular impingement (FAI) has been stated as one of the main causes of early osteoarthritis in the hip. This is particularly important in young athletes. However, there are no data available about the prevalence of radiological signs of FAI in the asymptomatic population. These data would improve the evaluation of athletes with groin pain to prevent further injuries. Objective The aim of this study is to show the prevalence of radiological signs of FAI in non-symptomatic athletes. Design Descriptive study. Setting Soccer and basketball players enrolled in elite division leagues. Participants Players were selected from the teams of the Federation of Soccer and Basketball of Murcia. Interventions Participants were clinical and radiologically evaluated. Clinical exam included: range of motion, and anterior and posterior hip impingement tests. Radiological exam included both anteroposterior radiographs of the pelvis and axial (frog-leg) views of both hips. Main outcome Radiographs were assessed to detect signs of FAI (both cam and pincer type). These signs were: pistol grip deformity (PG), coxa vara, alfa angle higher than 50°, anterior offset ratio (OR) lower than 0.18, coxa profunda/Protasio acetabuli (CP/PA), acetabular index lower o equal to 0°, cross-over sign (CO), and posterior wall sign (PW). Results 80 athletes were evaluated (mean (SD) age 24.43 (3.21)). PG was present in the 28.8%, alfa was higher than 50° in the 43.8%, CP/PA was detected in the 41.25%, CO was seen in the 25%, and PW in the 8.8%. Clinical signs of FAI, that is, groin pain with provocative test, were positive in the 13.8% of the patients. Conclusion Radiological evaluation shows a high prevalence of signs of FAI in athletic population. However, clinical signs are only present in a few of them.
A SMALLER BODY SIZE IS ASSOCIATED WITH A WORSE SAFETY PROFILE OF THE MITRACLIP PROCEDURE
Authors: Takashi Matsumoto, Wen-Loong Yeow, Asma Hussaini, Vinny Ram, Mamoo Nakamura, Moody Makar, Swaminatha Gurudevan, Alfredo Trento, Robert Siegel, Saibal Kar
Journal: Journal of the American College of Cardiology (2014)
Role of Injury and Hyperplasia in the Induction of Hepatocellular Carcinoma
Authors: Stanley Goldfarb
Journal: JAMA (1961)

THE INDUCTION of hepatocellular carcinoma is not dependent on continuous feeding of carcinogen. Short periods of exposure to carcinogen may result in tumors many weeks or months after drug withdrawal.<sup>1</sup>Nevertheless, hepatocellular injury and hyperplasia apparently precede the development of hepatomas. The persistence, regression, or alteration of early hepatocellular injury and hyperplasia were studied in rats after withdrawal of 3'-methyl-4-dimethylamino azobenzene (methyl butter yellow, MeBY), a potent carcinogen. Since 26 days of drug feeding causes a low incidence of hepatocellular carcinoma and 40 days a high incidence of hepatomas,<sup>2</sup>2 groups of rats fed the drug for these intervals were compared. Morphologic changes that were more prominent in the second group might be associated with hepatoma induction. The formation and persistence of nodules of hydropic, weakly basophilic cells, deficient in glucose-6-phosphatase (G-6-P' ase) that are closely associated with hepatocellular carcinoma will be described. <h3>Materials and Methods</h3> Sprague-Dawley male