tbuckley/cabot-search huggingface dataset:
In Vivo Evidence of Angiogenesis Induced by Transcription Factor Ets-1
Authors: Naotaka Hashiya, Nobuo Jo, Motokuni Aoki, Kunio Matsumoto, Toshikazu Nakamura, Yasufumi Sato, Nahoko Ogata, Toshio Ogihara, Yasufumi Kaneda, Ryuichi Morishita
Journal: Circulation (2004)

A transcription factor, ets-1, regulates the transcription of metalloproteinase genes, the activity of which is necessary for matrix degradation and the migration of endothelial cells. However, no study has demonstrated that ets-1 itself has an angiogenic action in vivo. Thus, we examined (1) the effects of overexpression of the ets-1 gene on angiogenesis in a rat hindlimb ischemia model, and (2) how ets-1 induced angiogenesis.In this study, we used the HVJ-liposome method, which is highly effective for transfection, to transfect the human ets-1 gene. At 4 weeks after transfection, the capillary density and blood flow were significantly increased in a hindlimb transfected with the human ets-1 gene compared with control. These data clearly demonstrated that ets-1 has the ability to stimulate angiogenesis in vivo. To elucidate the molecular mechanisms by which ets-1 induced angiogenesis, we focused especially on the expression of hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF), potent angiogenic growth factors, because the promoter regions of both genes contain ets binding sites. Interestingly, overexpression of ets-1 upregulated both tissue HGF and VEGF concentrations in rat hindlimb. More importantly, administration of neutralizing antibody against HGF and VEGF attenuated the increase in blood flow and BrdU-positive cells induced by ets-1. Upregulation of HGF and VEGF by ets-1 was also confirmed by in vitro experiments using human vascular smooth muscle cells.The present study demonstrated that ets-1 regulated angiogenesis through the induction of angiogenic growth factors (VEGF and HGF). Overexpression of ets may provide a new therapeutic strategy to treat peripheral arterial disease.
Prenatal Diagnosis of α1-Antitrypsin Deficiency by Direct Analysis of the Mutation Site in the Gene
Authors: Vincent J. Kidd, Mitchell S. Golbus, R. Bruce Wallace, Keiichi Itakura, Savio L. C. Woo
Journal: New England Journal of Medicine (1984)

A GENETIC deficiency of the plasma protease inhibitor α1-antitrypsin can lead to degenerative lung disease and fatal cirrhosis of the liver.1 , 2 The most common form of the deficiency, which occurs in persons who are homozygous for a Piz phenotype of the protein, has a prevalence of approximately one case per 2000 whites.3 A majority of the homozygous ZZ patients with the severe deficiency syndrome will contract chronic obstructive pulmonary emphysema, and 14 per cent will die of liver disease during early infancy.4 Previously, prenatal diagnosis of α1-antitrypsin deficiency has been possible only by Pi typing of blood samples . . .
The effect of the antimicrobial peptide, Dhvar-5, on gentamicin release from a polymethyl methacrylate bone cement
Authors: C. Faber, R.J.W. Hoogendoorn, D.M. Lyaruu, H.P. Stallmann, J. van Marle, A. van Nieuw Amerongen, T.H. Smit, P.I.J.M. Wuisman
Journal: Biomaterials (2005)
Two-dimensional echocardiographic recognition of left ventricular pseudoaneurysm.
Authors: E Catherwood, G S Mintz, M N Kotler, W R Parry, B L Segal
Journal: Circulation (1980)

Five consecutive patients with proved left ventricular pseudoaneurysm (PA) and 22 patients with true aneurysm (TA) were studied by two-dimensional echocardiography (2DE). In four of the five patients with PA, 2DE successfully displayed the PA. The unique 2DE characteristics of PA include: (1) a sharp discontinuity of the endocardial image at the site of the PA communication with the left ventricular cavity; (2) a saccular or globular contour of the PA chamber; and (3) the presence of a relatively narrow orifice in comparison with the diameter of the PA fundus. In addition, 2DE detected the presence of thrombotic material within the extraventricular chamber in three of four cases. By deriving the ratios of the end-systolic orifice to diameter measurements for the patients with PA (0.37 +/- 0.07) compared with TA (1.00 +/- 0.08), we found that 2DE reliably differentiated PA from TA (p < 0.001). We conclude that 2DE is a useful noninvasive method for revealing left ventricular PAs and for distinguishing PA from TA. Considering the high risk of spontaneous rupture associated with pseudoaneurysms, this noninvasive capability is of paramount clinical importance.
Dermatomyositis with the features of inclusion body myositis associated with carcinoma of the bladder
Authors: N.Y. Talanin, D. Bushore, R. Rasberry, T. Rudolph, M. Tuli, R. Friedman-Musicante
Journal: British Journal of Dermatology (1999)

Journal Article Dermatomyositis with the features of inclusion body myositis associated with carcinoma of the bladder Get access N.Y. Talanin, N.Y. Talanin Division of Dermatology, Department of Medicine, The University of Tennessee, 956 Court Avenue, Room E332, Memphis TN 38163, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar D. Bushore, D. Bushore Division of Dermatology, Department of Medicine, The University of Tennessee, 956 Court Avenue, Room E332, Memphis TN 38163, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar R. Rasberry, R. Rasberry Division of Dermatology, Department of Medicine, The University of Tennessee, 956 Court Avenue, Room E332, Memphis TN 38163, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar T. Rudolph, T. Rudolph Division of Dermatology, Department of Medicine, The University of Tennessee, 956 Court Avenue, Room E332, Memphis TN 38163, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar M. Tuli, M. Tuli Division of Dermatology, Department of Medicine, The University of Tennessee, 956 Court Avenue, Room E332, Memphis TN 38163, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar R. Friedman‐Musicante R. Friedman‐Musicante Division of Dermatology, Department of Medicine, The University of Tennessee, 956 Court Avenue, Room E332, Memphis TN 38163, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 141, Issue 5, 1 November 1999, Pages 926–930, https://doi.org/10.1046/j.1365-2133.1999.03172.x Published: 01 November 1999
Teaching Peer Review
Authors: Peter Peterson
Journal: JAMA (1973)

In recent years there has been increased interest in peer review as a method of maintaining a high quality of patient care. There has also been a twofold assumption that physicians willingly accept peer review and are able to perform a review immediately on completion of a residency program. I believe this assumption has basic weaknesses, and that for peer review to be effective, it is necessary to teach the review process to medical students and members of the house staff.  Observations  The medical audit is a retrospective examination of the clinical application of our medical knowledge. The audit should be an educational process, the result of which may be to alter the physician's medical behavior. In this way, the level of medical care in an institution or a community can be continuously reviewed and improved.  When the audit is performed by practicing physicians and includes an evaluation of the
Trial of nedocromil sodium in atopic eczema
Authors: E.C. BENTON, H.A.F. MCFARLANE, R.ST.C. BARNETSON
Journal: British Journal of Dermatology (1990)

The efficacy of orally administered nedocromil sodium, a mast-cell stabilizer, was assessed in the treatment of adults with atopic eczema plus food allergy. Twenty adults with atopic eczema and allergy to hens' eggs, cows' milk or wheat took part in this double-blind, cross-over study of nedocromil sodium versus placebo, each treatment period lasting 4 weeks. No significant differences were found between the two treatments on clinical assessment, or by measurement of total and specific IgE levels.
Electrocardiogram in Rabbit Fetuses
Authors: ANTHONY J. SAEZ, JOHN V. BASMAJIAN
Journal: Circulation Research (1963)

Electrocardiograms were recorded by needle electrodes in 137 of 166 rabbit fetuses at 10½ to 31 days. Invariably, electrocardiograms were obtainable from the 12th day on, which in the rabbit is an early stage of development. The earliest electrocardiogram was obtained at 10 days, 22 hours, corresponding to about five weeks in human development. Sinus rhythm was evident from the start. The wave form consists of a pair of complexes 50 to 200 msec apart. The first complex is quite variable but appears to be atrial in origin; the second is surprisingly constant and appears to be ventricular.
Anterior Tibial Syndrome Due to Arterial Embolism and Thrombosis
Authors: B. J. Freedman, C. H. R. Knowles
Journal: BMJ (1959)

<h3>Abstract</h3> Assessment of the diversity and composition of biological communities is central to studies in ecology as well as for ecological monitoring. Historically, individual taxonomic groups have been assessed separately, while for an understanding of the state and change of biodiversity under ongoing global change an integrated assessment would be necessary. DNA metabarcoding has been proposed to be a highly promising approach especially for the assessment of aquatic communities, and numerous studies have investigated the consistency of this new technique with traditional morpho-taxonomic approaches. These individual studies have used DNA metabarcoding to assess diversity and community structure of aquatic organisms both in marine and freshwater systems globally over the last decade. However, a systematic analysis of the comparability and effectiveness of DNA-based community assessment across all of these studies has hitherto been lacking. Here we performed the first meta-analysis of all available studies comparing traditional methods and DNA metabarcoding to measure and assess biological diversity of key aquatic groups, including microorganisms, macroinvertebrates, and fish. Across 215 datasets, we found that DNA metabarcoding provides diversity estimates (richness) that are globally consistent to those obtained using traditional methods. DNA metabarcoding also generates species inventories that are highly congruent with traditional methods for fish. Contrastingly, however, species inventories of microorganisms and macroinvertebrates obtained by DNA metabarcoding showed pronounced differences to traditional methods, missing some taxa but at the same time detecting otherwise overseen diversity. Our results indicate that DNA metabarcoding is efficient to estimate local and regional richness. The method is generally sufficiently advanced to study the composition of fish communities and replace more invasive traditional methods. For smaller organisms, like macroinvertebrates and microorganisms, DNA metabarcoding may continue to give complementary rather than identical estimates compared to traditional approaches. Systematic and comparable data collection will increase the understanding of different aspects of this complementarity, and increase the effectiveness of the method and adequate interpretation of the results.
Massachusetts Medical Society
Authors: Walter B. Lancaster
Journal: New England Journal of Medicine (1951)

To be chosen to give the keynote address on the occasion of the founding of this Section is a mark of distinction that I appreciate as much as if I deserved it and that I accept with mingled feelings of pride and of humility.Let me sound the keynote of our meetings — rather let me sound the major chord on which the harmony will be founded. The first note of the chord is enthusiasm! Note the derivation of the word — ένθεος — a god within. As Pasteur exclaimed after thanking the Greeks for one of the most beautiful . . .
Pancreatitis, Encephalomalacia, and Hypothermia.
Authors: Erskine M. Caperton
Journal: Annals of Internal Medicine (1968)

s1 May 1968Pancreatitis, Encephalomalacia, and Hypothermia.Erskine M. Caperton Jr., M.D., Ralph C. Williams Jr., M.D.Erskine M. Caperton Jr., M.D.Search for more papers by this author, Ralph C. Williams Jr., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1145_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMany peripheral or systemic manifestations of pancreatitis such as widespread fat necrosis, coagulation disorders, pleural or pericardial effusions, eosinophilia, or hyperlipemia have been extensively documented in clinical reports. Despite the well-known systemic manifestations of acute pancreatic inflammation, little attention has been devoted to central nervous system lesions occurring with pancreatitis. This report concerns six patients who died with acute pancreatitis and were found at autopsy to have distinct acute encephalomalacia including focal areas of brain necrosis (four cases) and neuronal degeneration of internal granular layers of cerebellum (two cases). The pancreatitis-encephalomalacia syndrome was marked by profound terminal hypothermia in three... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1145-1146KeywordsCerebellumCoagulation disordersEosinophiliaFatsHyperlipidemiaHypothermiaInflammationLesionsNecrosisPancreatitis Issue Published: 1 May 1968 PDF downloadLoading ...
RIGOR MORTIS AND THE INFLUENCE OF CALCIUM AND MAGNESIUM SALTS UPON ITS DEVELOPMENT
Authors: S. J. Meltzer, John Auer
Journal: The Journal of Experimental Medicine (1908)

Calcium salts hasten and magnesium salts retard the development of rigor mortis, that is, when these salts are administered subcutaneously or intravenously. When injected intra-arterially, concentrated solutions of both kinds of salts cause nearly an immediate onset of a strong stiffness of the muscles which is apparently a contraction, brought on by a stimulation caused by these salts and due to osmosis. This contraction, if strong, passes over without a relaxation into a real rigor. This form of rigor may be classed as work-rigor (Arbeitsstarre). In animals, at least in frogs, with intact cords, the early contraction and the following rigor are stronger than in animals with destroyed cord. If M/8 solutions-nearly equimolecular to "physiological" solutions of sodium chloride-are used, even when injected intra-arterially, calcium salts hasten and magnesium salts retard the onset of rigor. The hastening and retardation in this case as well as in the cases of subcutaneous and intravenous injections, are ion effects and essentially due to the cations, calcium and magnesium. In the rigor hastened by calcium the effects of the extensor muscles mostly prevail; in the rigor following magnesium injection, on the other hand, either the flexor muscles prevail or the muscles become stiff in the original position of the animal at death. There seems to be no difference in the degree of stiffness in the final rigor, only the onset and development of the rigor is hastened in the case of the one salt and retarded in the other. Calcium hastens also the development of heat rigor. No positive facts were obtained with regard to the effect of magnesium upon heat vigor. Calcium also hastens and magnesium retards the onset of rigor in the left ventricle of the heart. No definite data were gathered with regard to the effects of these salts upon the right ventricle.
Phase 2 Study of Pemetrexed and Itraconazole as Second-Line Therapy for Metastatic Nonsquamous Non–Small-Cell Lung Cancer
Authors: Charles M. Rudin, Julie R. Brahmer, Rosalyn A. Juergens, Christine L. Hann, David S. Ettinger, Rosa Sebree, Ruth Smith, Blake T. Aftab, Peng Huang, Jun O. Liu
Journal: Journal of Thoracic Oncology (2013)
Oesophageal achalasia mistaken for anorexia nervosa.
Authors: J. McSherry
Journal: BMJ (1992)

their general practitioner.Taking into considera- tion the points already made about possible reasons for their visit to the department and the general nature of the question asked, the figure does not seem to differ from that found in other studies.2The study asked a vague general question about consultations with a general practitioner before the visit to the accident and emergency department and consequently got vague general data, from which no conclusions can be drawn.Perhaps more disturbing is the implied criticism of general practitioners' diagnostic ability.I hope that I am being hypersensitive after my second 120 hour week this month and that no such criticism was meant.
Humour and alarmism in melanoma prevention: a randomized controlled study of three types of information leaflet
Authors: M A Richard, S Martin, J Gouvernet, G Folchetti, J J Bonerandi, J J Grob
Journal: British Journal of Dermatology (1999)

Journal Article Humour and alarmism in melanoma prevention: a randomized controlled study of three types of information leaflet Get access M A Richard, M A Richard Service de Dermatologie, Hôpital Sainte Marguerite, 270 Bd de Sainte Marguerite,13009 Marseille, France,LIMP (Laboratoire d'Investigation des Maladies de la Peau), UPRES JE 2050, Hôpital Sainte Marguerite, 13009 Marseille, France, Search for other works by this author on: Oxford Academic Google Scholar S Martin, S Martin Service de Dermatologie, Hôpital Sainte Marguerite, 270 Bd de Sainte Marguerite,13009 Marseille, France, Search for other works by this author on: Oxford Academic Google Scholar J Gouvernet, J Gouvernet Service d'Informatique Médicale, Hôpital Timone, 13005 Marseille, France Search for other works by this author on: Oxford Academic Google Scholar G Folchetti, G Folchetti Service de Dermatologie, Hôpital Sainte Marguerite, 270 Bd de Sainte Marguerite,13009 Marseille, France, Search for other works by this author on: Oxford Academic Google Scholar J J Bonerandi, J J Bonerandi Service de Dermatologie, Hôpital Sainte Marguerite, 270 Bd de Sainte Marguerite,13009 Marseille, France,LIMP (Laboratoire d'Investigation des Maladies de la Peau), UPRES JE 2050, Hôpital Sainte Marguerite, 13009 Marseille, France, Search for other works by this author on: Oxford Academic Google Scholar J J Grob J J Grob Service de Dermatologie, Hôpital Sainte Marguerite, 270 Bd de Sainte Marguerite,13009 Marseille, France,LIMP (Laboratoire d'Investigation des Maladies de la Peau), UPRES JE 2050, Hôpital Sainte Marguerite, 13009 Marseille, France, J J Grob, E‐mail: jgrob@ap‐hm.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 140, Issue 5, 1 May 1999, Pages 909–914, https://doi.org/10.1046/j.1365-2133.1999.02824.x Published: 01 May 1999
Betting on Biomarkers
Authors: Roy H. Perlis
Journal: American Journal of Psychiatry (2011)

In this issue, Johnson and colleagues (1) report on a study of ondansetron, a serotonin receptor antagonist, for alcohol-dependent patients.Had they conducted a standard randomized placebo-controlled trial, they would have found no statistically significant difference between treatment groups on the primary outcome measure and stopped there.That is, on average, their study participants were not significantly less likely to drink if they received ondansetron than if they received placebo.Instead, however, the authors made an important and risky bet, choosing to stratify randomization according to a common genetic variation and then to analyze their results within genetically defined subgroups.With the use of a biological marker, an otherwise murky picture of treatment response became clearer, pointing to a potential novel intervention for drinking-but only in one patient subgroup.
Quantification of Orbital and Mid-facial Growth Retardation after Megavoltage External Beam Irradiation in Children with Retinoblastoma
Authors: Saskia M. Imhof, Maarten Ph. Mourits, Pieter Hofman, Frans W. Zonneveld, Jan Schipper, Annette C. Moll, Karel E.W.P. Tan
Journal: Ophthalmology (1996)
Baicalin increases VEGF expression and angiogenesis by activating the ERR /PGC-1 pathway
Authors: K. Zhang, J. Lu, T. Mori, L. Smith-Powell, T. W. Synold, S. Chen, W. Wen
Journal: Cardiovascular Research (2010)

Baicalin is the major component found in Scutellaria baicalensis root, a widely used herb in traditional Chinese medicine. Although it has been used for thousands of years to treat stroke, the mechanisms of action of S. baicalensis have not been clearly elucidated. In this report, we studied the modulation of angiogenesis as one possible mechanism by investigating the effects of these agents on expression of vascular endothelial growth factor (VEGF), a critical factor for angiogenesis.The effects of baicalin and an extract of S. baicalensis on VEGF expression were tested in several cell lines. Both agents induced VEGF expression in all cells without increasing expression of hypoxia-inducible factor-1α (HIF-1α). The expression of reporter genes was also activated under the control of the VEGF promoter containing either a functional or a defective HIF response element (HRE). Only minimal effects were observed on reporter activation under the HRE promoter. Instead, both agents significantly induced oestrogen-related receptor (ERRα) expression as well as the activity of reporter genes under the control of ERRα-binding element. Their ability to induce VEGF expression was suppressed once ERRα expression was knocked down by siRNA or ERRα-binding sites were deleted in the VEGF promoter. We also found that both agents stimulated cell migration and vessel sprout formation from the aorta.Our results implicate baicalin and S. baicalensis in angiogenesis by inducing VEGF expression through the activation of the ERRα pathway. These data may facilitate a better understanding of the potential health benefits of these agents in the treatment of cardiovascular diseases.
The melatonin-cytokine connection in rheumatoid arthritis
Authors: M Cutolo
Journal: Annals of the Rheumatic Diseases (2005)

<h3>Abstract</h3> There is longstanding interest in the relationship between motor imagery, action observation, and movement execution. Several models propose that these tasks recruit the same brain regions in a similar manner; however, there is no quantitative synthesis of the literature that compares their respective networks. Here we summarized data from neuroimaging experiments examining Motor Imagery (303 experiments, 4,902 participants), Action Observation (595 experiments, 11,032 participants), and related control tasks involving Movement Execution (142 experiments, 2,302 participants). Motor Imagery recruited a network of premotor-parietal cortical regions, alongside the thalamus, putamen, and cerebellum. Action Observation involved a cortical premotor-parietal and occipital network, with no consistent subcortical contributions. Movement Execution engaged sensorimotor-premotor areas, and the thalamus, putamen, and cerebellum. Comparisons across these networks highlighted key differences in their recruitment of motor cortex,and parietal cortex, and subcortical structures. Conjunction across all three tasks identified a consistent premotor-parietal and somatosensory network. These data amend previous models of the relationships between motor imagery, action observation, and movement execution, and quantify the relationships between their respective networks. <h3>Highlights</h3> We compared quantitative meta-analyses of movement imagery, observation, and execution Subcortical structures were most commonly associated with imagery and execution Conjunctions identified a consistent premotor-parietal-somatosensory network These data can inform basic and translational work using imagery and observation