Itraconazole-Digoxin Interaction
Authors: John Rex
Journal: Annals of Internal Medicine (1992)

Letters15 March 1992Itraconazole-Digoxin InteractionJohn Rex, MDJohn Rex, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-6-525 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Itraconazole, a triazole derivative of ketoconazole, has shown substantial promise as therapy for fungal infections (1). Interactions between itraconazole and cyclosporine, phenytoin, rifampin, and carbamazepine have been reported (2, 3), and our experience suggests that an interaction also occurs between itraconazole and digoxin.A 68-year-old man developed right elbow swelling, and Sporothrix schenckii osteoarthritis was diagnosed after joint debridement. After month-long trials of SSKI (saturated solution of potassium iodide) and then ketoconazole (200 mg bid) failed to improve his joint, he was referred to us. The patient's past medical history was pertinent for atrial fibrillation, which had...References1. PhillipsFetchickWeismanFosheeGraybill PRISJ. Tolerance and efficacy of itraconazole in treatment of systemic mycoses: preliminary results. Rev Infect Dis. 1987;9(Suppl 1):587-93. Google Scholar2. KramerMarshallDenning MSD. Cyclosporine and itraconazole interaction in heart and lung transplant recipients. Ann Intern Med. 1990;113:327-9. LinkGoogle Scholar3. TuckerDenningHanson RDL. Interaction of azoles with rifampin, phenytoin, and carbamazepine: in vitro and clinical observations. Clin Infect Dis. 1992;14:165-74. CrossrefMedlineGoogle Scholar4. HoffmanBigger BJ. Digitalis and allied cardiac glycosides. In: Gilman AG, Rall TW, Nies AS, Taylor P, eds. The Pharmacological Basis of Therapeutics. Elmsford, New York: Pergamon Press; 1990:814-39. Google Scholar5. Heykantsvan Peervan de Velde JAV. The clinical pharmacokinetics of itraconazole: an overview. Mycoses. 1989;32(Suppl 1):67-87. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: National Institutes of Health Bethesda, MD 20892 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAzolesAbility of pharmacy clinical decision-support software to alert users about clinically important drug—drug interactionsItraconazoleDrug interactions in the hematopoietic stem cell transplant (HSCT) recipient: what every transplanter needs to knowNew agents for the treatment of systemic fungal infections – current statusEffect of itraconazole on the pharmacokinetics of prednisolone and methylprednisolone and cortisol secretion in healthy subjectsPharmacokinetic Aspects of Treating Infections in the Intensive Care UnitEffects of the Antifungal Agents on Oxidative Drug MetabolismScedosporium apiospermum–Associated GonarthritisMechanisms underlying variability in response to drug therapy: implications for amiodarone useDrug interactions with itraconazole, fluconazole, and terbinafine and their managementEffect of itraconazole on the pharmacokinetics of digoxin in guinea pigsMETABOLISM-BASED DRUG INTERACTIONS INVOLVING ORAL AZOLE ANTIFUNGALS IN HUMANS*Antifungal Agents. Part II. The AzolesUpdate on Drug Interactions with Azole Antifungal AgentsA Model for the Prediction of Digoxin-Drug Interactions at the Renal Tubular Cell LevelItraconazole Decreases Renal Clearance of DigoxinManagement of Drug Interactions in Patients with HIVComment: Possible Mechanism of Digoxin–Itraconazole InteractionDigoxin–Itraconazole Interaction: Possible MechanismsPediatrics: Treatment of Tinea CapitisUse of Azoles for Systemic Antifungal TherapyItraconazole Increases Serum Digoxin ConcentrationNew Antifungal Drugs for Pulmonary MycosesAntifungal prophylaxis with itraconazole in neutropenic patients: pharmacological, microbiological and clinical aspectsItraconazole: pharmacology, clinical experience and future developmentUpdate on Invasive CandidiasisAntifungal agents: An overview. Part IIItraconazole: A New Triazole Antifungal AgentDigoxin‐itraconazole interactionIbrotamidDigoxin interaction 15 March 1992Volume 116, Issue 6Page: 525-525KeywordsAtrial fibrillationElbowInflammationOsteoarthritisPotassium Issue Published: 15 March 1992 PDF downloadLoading ...