Cimetidine and Agranulocytosis
Authors: FIRAS H. AL-KAWAS
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 June 1979Cimetidine and AgranulocytosisFIRAS H. AL-KAWAS, M.D., BRUCE A. LENES, M.D., RONALD A. SACHER, M.D.FIRAS H. AL-KAWAS, M.D.Search for more papers by this author, BRUCE A. LENES, M.D.Search for more papers by this author, RONALD A. SACHER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-6-992 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the letter by de Galocsy and van Ypersele de Strihou (1) and the editorial by Freston (2) in the February 1979 issue.Cimetidine has been reported in association with pure agranulocytosis in only two cases (3, 4). The remainder of the cases were granulocytopenia (5, 6) and pancytopenia (1, 7). In addition, the exact association with cimetidine in the cases of agranulocytosis appears far from certain in view of the complex drug therapy in the first case and the long interval before the onset of agranulocytosis in the second.We report a case...References1. DE GALOCSYVAN YPERSELE DE STRIHOU CC: Pancytopenia with cimetidine (letter). Ann Intern Med 90:274, 1979 LinkGoogle Scholar2. FRESTON J: Cimetidine and granulocytopenia. Ann Intern Med 90:264, 1979 LinkGoogle Scholar3. KLOTZKAY SB: Cimetidine and agranulocytosis (letter). Ann Intern Med 88:579-580, 1978 LinkGoogle Scholar4. CRAVENWHITTINGTON EJ: Agranulocytosis four months after cimetidine therapy (letter). Lancet 2:294-295, 1977 CrossrefMedlineGoogle Scholar5. JOHNSONMCI BLACKHUGHESCLARKE NAAS: Leukopenia with cimetidine (letter). Lancet 2:1226, 1977 CrossrefGoogle Scholar6. UFBERGBROOKSBOSANACKINTZEL MCPJ: Transient neutropenia in a patient receiving Cimetidine. Gastroenterology 73:635-638, 1977 CrossrefMedlineGoogle Scholar7. SELKERMOORELODOLCE RPD: Bone-marrow depression with cimetidine plus carmustine (letter). N Engl J Med 299:834, 1978 CrossrefMedlineGoogle Scholar8. TSANMEHLMANGREENBELL MDRW: Dilantin®, agranulocytosis, and phagocytic marrow histiocytes (letter). Ann Intern Med 84:710-711, 1976 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Georgetown University Hospital 3800 Reservoir Road, N.W.; Washington, DC 20007 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHaematological Adverse Effects of Histamine H2-Receptor AntagonistsAdverse Reactions and Interactions with H2-Receptor AntagonistsCimetidine suppression of CFU-C in malesDistribution of Cimetidine in Postmortem TissuesReview of Cimetidine Drug InteractionsGastrointestinal DrugsSevere Granulocytopenia with Cimetidine and PhenytoinELIZABETH SAZIE, M.D., JEFFRY P. JAFFE, M.D.Cimetidine-lnduced GranulocytopeniaHARRY W. CARLOSS, M.D., MEHDI TAVASSOLI, M.D., ROBERT MCMILLAN, M.D.H 2 Antihistamines (Cimetidine) and Allergic-Inflammatory ReactionsAntihistamines 1 June 1979Volume 90, Issue 6Page: 992-993KeywordsDrug therapy Issue Published: 1 June 1979 PDF DownloadLoading ...