tbuckley/cabot-search huggingface dataset:
Tumor Cell Responses to IFNγ Affect Tumorigenicity and Response to IL-12 Therapy and Antiangiogenesis
Authors: Christina M. Coughlin, Kevin E. Salhany, Michael S. Gee, Denise C. LaTemple, Serguei Kotenko, XiaoJing Ma, Giorgia Gri, Maria Wysocka, Ji Eun Kim, Li Liu, Fang Liao, Joshua M. Farber, Sidney Pestka, Giorgio Trinchieri, William M.F. Lee
Journal: Immunity (1998)

Expression of a dominant negative mutant IFNgammaR1 in murine SCK and K1735 tumor cells rendered them relatively unresponsive to IFNgamma in vitro and more tumorigenic and less responsive to IL-12 therapy in vivo. IL-12 induced histologic evidence of ischemic damage only in IFNgamma-responsive tumors, and in vivo Matrigel vascularization assays revealed that while IFNgamma-responsive and -unresponsive tumor cells induced angiogenesis equally well, IL-12 and its downstream mediator IFNgamma only inhibited angiogenesis induced by the responsive cells. IL-12 induced angiogenesis inhibitory activity in the responsive cells, which may be attributable to production of the chemokine IP-10. Thus, IL-12 and IFNgamma inhibit tumor growth by inducing tumor cells to generate antiangiogenic activity.
THREE RECENT CASES OF TUBAL PREGNANCY
Authors: C. E. Purslow
Journal: BMJ (1909)

AoAt'I 943 bed, and the case regarded and treated as one of peritonitis, and .nofurther acute attacks supervened.Two days latershe passed a piece of membrane 3 in.long, and there was moderate uterine haemorrhage for a few days.Altogether she was in bed -about three weeks, and then, on attempting to get up, the acute pain returned, and she had to go back to bed again.She now noticed that her abdomen was getting smaller, and her health remained in a very unsatisfactory condition, with constant abdominal pain, until her admission to the hospital on August 19th, two and a half months after the attack of acute pain.Her pulse and temperature were at this time., normal, and her sgeneral condition good.An abdominal tumour was found, solid, hard, and.tender; it lay behind the cervix, and thence .extendedupwards to the right side, to a point half way between the pubes and the umbilicus.It appeared to be quite inde- -pendent of the uterus, and the history was strongly suggestive *of an extrauterine gestation.At the operation on August 24th it tur4ned, out to be pregnancy in the undeveloped left horn of a bicornute uterus; there was a fetus of about five months' development, and rupture had occurred with partial extrusion -of the fetus, the placenta having been retained entirely within the dilated uterine horn.Omentum and coils of intestine were closely adherent to the gestation sac and the body of the fetus, -and there was little free blood found in the peritoneal cavity.
The associations of body size and body composition with left ventricular mass: impacts for indexation in adults
Authors: Hans-Werner Hense, Birgit Gneiting, Michael Muscholl, Ulrich Broeckel, Bernhard Kuch, Angela Doering, Günter A.J Riegger, Heribert Schunkert
Journal: Journal of the American College of Cardiology (1998)
Encephalopathy and Fatty Degeneration of the Liver and Kidneys
Authors: J. T. Jabbour
Journal: JAMA (1965)

IN 1963, Reye et al<sup>1</sup>described a new clinicopathologic entity: "encephalopathy and fatty degeneration of the viscera." The illness began with a mild upper-respiratory-tract infection which subsided and was followed by profuse vomiting, fever, convulsions, and marked alteration in consciousness, respirations, muscle tone, and deep-tendon reflexes. Laboratory findings included hypoglycemia, hypoglycorrhachia, mild acidosis and ketosis and elevation of blood urea nitrogen (BUN), serum glutamic oxaloacetic transaminase, and serum glutamic pyruvic transaminase values. Seventeen of the 21 patients died. At postmortem examination, diffuse cerebral swelling, without herniation, and marked fatty infiltration of the liver and proximal tubules of the kidneys were uniformly demonstrated. Although about 50 patients have been described in the English, Australian, and New Zealand literature, only recently have similar reports appeared from the United States.<sup>2-5</sup>This is the report of another patient and a review of the features of this unusual illness.
Shifts in Thinking About Dementia
Authors: Vladimir Hachinski
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Accuracy of an intelligent CPAP machine with in-built diagnostic abilities in detecting apnoeas: a comparison with polysomnography.
Authors: M Gugger, J Mathis, C Bassetti
Journal: Thorax (1995)

In patients with sleep apnoea early diagnostic evaluation and treatment may be delayed due to limited access to full polysomnography (PSG). For "typical" patients, simplified strategies are needed. A study was performed to evaluate the accuracy of a new continuous positive airway pressure (CPAP) device with in-built diagnostic abilities (Autoset) in detecting apnoeas.Twenty seven patients underwent full overnight polysomnography. Data with the Autoset were acquired simultaneously. Standard nasal prongs were used. Apnoeas were detected by special analysis of the flow signal. As the Autoset derives all its data from one signal, careful examination of the raw data is important to assess the quality of the flow signal.There was a correlation between the apnoea index (AI) assessed by the Autoset (AI-Autoset) and by polysomnography AI-PSG (r = 0.85) and between the AI-Autoset and the apnoea/hypopnoea index (AHI) during polysomnography (r = 0.87). The Autoset identified patients with an AHI-PSG of > 20 (a level of respiratory disturbance that would warrant consideration for treatment in most centres for sleep disorders) with a sensitivity of 82% and a specificity of 90%.The good correlation between the apnoea index measured by the Autoset and by polysomnography, and the high sensitivity in detecting patients with an AHI of > 20, may make the Autoset a valuable tool for the management of typical patients with sleep apnoea. However, very low values for nasal ventilation on the printout raises the suspicion of poor signal quality and misleading results.
Cell Invasion in Collagen Scaffold Architectures Characterized by Percolation Theory
Authors: Jennifer C. Ashworth, Marco Mehr, Paul G. Buxton, Serena M. Best, Ruth E. Cameron
Journal: Advanced Healthcare Materials (2015)

The relationship between biological scaffold interconnectivity and cell migration is an important but poorly understood factor in tissue regeneration. Here a scale-independent technique for characterization of collagen scaffold interconnectivity is presented, using a combination of X-ray microcomputed tomography and percolation theory. Confocal microscopy of connective tissue cells reveals this technique as highly relevant for determining the extent of cell invasion.
Cocaine increases natural killer cell activity.
Authors: C Van Dyke, A Stesin, R Jones, A Chuntharapai, W Seaman
Journal: Journal of Clinical Investigation (1986)

The administration of epinephrine to humans increases natural killer (NK) cell activity and numbers. If endogenous catecholamines regulate NK cells, then their activity should be increased by cocaine, an agent that potentiates endogenous catecholamines. We investigated the in vivo effect of cocaine on NK cell activity and on the distribution of lymphocyte subsets, including NK cells. Intravenous cocaine (0.6 mg/kg) produced a three- to fourfold increase in NK cell activity in peripheral blood. The increase was accompanied by a marked and selective increase in circulating NK cells, as identified by the Fc receptor (Leu-11). Normal saline and benzoylecgonine, a major metabolite of cocaine, had little effect on NK cell activity or on levels of Leu-11+ cells. Other lymphocyte subpopulations were not increased by cocaine. The time course of the alterations in NK cell numbers and activity paralleled plasma levels of cocaine. In vitro cocaine did not increase NK cell activity. Our results indicate that cocaine selectively alters the activity and distribution of the NK lymphocyte subset. Because cocaine increases the activity of endogenous catecholamines, these findings suggest that human NK cells are selectively regulated by the sympathetic nervous system.
Reply to Comments from Schreiber et al.
Authors: C. Sebesta, A. Rokitansky, H. Rosen, A. Schmid, P. Kier, R. Ruckser, W. Hinterberger
Journal: Endoscopy (1996)

See also: ERCP and Balloon Dilation is a Valuable Alternative to Surgical Biliodigestive Anastomosis in the Long Common Channel Syndrome in ChildhoodEndoscopy 1996; 28(08): 724-724DOI: 10.1055/s-2007-1005585
Proton Radiation as Boost Therapy for Localized Prostatic Carcinoma
Authors: William U. Shipley
Journal: JAMA (1979)

A 160-MeV proton beam has been modified to irradiate patients with localized tumors by using convention treatment schedules. This proton beam has the physical advantage of megavoltage x-rays of reducing the radiation dose to normal tissues adjacent to the tumor volume. A perineal proton technique used as boost therapy (2,000 to 2,500 rads) was evaluated in the definitive irradiation of 17 patients with localized prostatic carcinoma. This technique allows repeated daily treatment of the carefully defined target volume with a precision of +/- 2 mm. Total dose to the prostatic tumor, but not to the posterior rectum, has been increased by 500 to 700 rads. After 12 to 27 months of observation, no noteworthy rectal reaction has developed in a patient, easily managed urethral strictures have developed in two patients, and all but one are locally controlled.
Computed Tomography Characteristics Predictive for Radial EBUS-Miniprobe-Guided Diagnosis of Pulmonary Lesions
Authors: Canan Guvenc, Jonas Yserbyt, Dries Testelmans, Federica Zanca, An Carbonez, Vincent Ninane, Walter De Wever, Christophe Dooms
Journal: Journal of Thoracic Oncology (2014)
A 69-Year-Old Man With Anger and Angina
Authors: Redford B. Williams
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multifunctional and stable bone mimic proteinaceous matrix for bone tissue engineering
Authors: Jong-Eun Won, Ye-Rang Yun, Jun-Hyeog Jang, Sung-Hee Yang, Joong-Hyun Kim, Wojciech Chrzanowski, Ivan B. Wall, Jonathan C. Knowles, Hae-Won Kim
Journal: Biomaterials (2015)
Fibroblast Growth Factor-2 Gene Transfer Can Stimulate Hepatocyte Growth Factor Expression Irrespective of Hypoxia-Mediated Downregulation in Ischemic Limbs
Authors: Mitsuho Onimaru, Yoshikazu Yonemitsu, Mitsugu Tanii, Kazunori Nakagawa, Ichiro Masaki, Shinji Okano, Hiroaki Ishibashi, Kanemitsu Shirasuna, Mamoru Hasegawa, Katsuo Sueishi
Journal: Circulation Research (2002)

Hepatocyte growth factor (HGF) is a potent angiogenic polypeptide that stimulates angiogenesis. Transcriptional regulation of HGF, however, has not been fully defined, with the exception of the hypoxia-mediated downregulation in cultured cells. In the present study, we report that angiogenic growth factors, including HGF, were upregulated in a murine model of critical limb ischemia in vivo, a finding that was in conflict with previous in vitro data. Mice deficient in basic fibroblast growth factor-2 (FGF-2) showed reduced induction of HGF protein in ischemic muscles, and overexpression of FGF-2 via gene transfer stimulated endogenous HGF, irrespective of the presence of ischemia. In culture, FGF-2 rapidly stimulated HGF mRNA, and a sustained expression was evident in the time course in vascular smooth muscle cells and fibroblasts. FGF-2–mediated induction of HGF was fully dependent on the mitogen-activated protein kinase pathway yet was not affected by either hypoxia or a protein kinase A inhibitor. In the early expression, FGF-2 directly stimulated HGF mRNA without the requirement of new protein synthesis, whereas sustained induction of HGF in the later phase was partly mediated by platelet-derived growth factor-AA. Furthermore, in vivo overexpression of FGF-2 significantly improved the blood perfusion, and the effect was abolished by systemic blockade of HGF in ischemic limbs. This is the first demonstration of a regulational mechanism of HGF expression via FGF-2 that was independent of the presence of hypoxia. The harmonized therapeutic effects of FGF-2, accompanied with the activity of endogenous HGF, may provide a beneficial effect for the treatment of limb ischemia.
Purulent Cholangitis and Hepatic Abscess after Choledochoduodenostomy Diagnosed by ERCP
Authors: I. Szántó, I. Bozalyi, I. Vámosi, G. Sarkadi
Journal: Endoscopy (1979)

The authors report on a case of purulent cholangitis and hepatic abscess developing 5 years after choledochoduodenostomy, diagnosed by means of ERCP. They believe viscous pus adhering to the wall of the bile ducts to be responsible, as a mechanical factor, for causing the inhibiting bile discharge. After the ERCP examination, the patient became free from complaints, and could be discharged.
Restoration by purified C3b inactivator of complement-mediated function in vivo in a patient with C3b inactivator deficiency.
Authors: J B Ziegler, C A Alper, R S Rosen, P J Lachmann, L Sherington
Journal: Journal of Clinical Investigation (1975)

In a patient with lifelong increased susceptibility to infection and multiple abnormalities in complement-mediated functions, the infusion of normal plasma had been seen to produce a prolonged partial correction of serum abnormalities. It was subsequently shown that the patient was genetically deficient in the C3b inactivator and that immunochemical depletion of C3b inactivator from normal serum resulted in abnormalities similar to those found in the patient's serum, including alternative pathway C3 activation. Highly purified C3b inactivator was obtained from the euglobulin fraction of normal human serum, sterilized by filtration, and infused intravenously. Partial or complete correction of almost all the known serum abnormalities was obtained. C3b almost disappeared from the serum within 4-5 h, as did Factor C activity. Native C3, C5, and serum hemolytic activity rose to normal or near-normal levels over 4 days and were sustained for another week. Factor B, properdin, opsonic activity, and bactericidal activity reached a level at least two-five times that found before the infusion within 24 h and fell over the next 5 days. These observations prove the primary role of C3b inactivator deficiency in the patient's disease and demonstrate clearly the curcial role in vivo of C3b inactivator in modulating alternative pathway activity.
Biochemical testing for acute medical emergencies.
Authors: C Sanderson
Journal: BMJ (1979)

months.Three of them had had unsuccessful kidney transplants before CAPD and the fourth, a 3-year old, had Wilms's tumours.Although our experience is still too short to allow us more generalised conclusions, we are convinced that the availability of CAPD in- creases the therapeutic armamentarium in the management of children with end-stage renal disease.
Fasting Girls: The Emergence of Anorexia Nervosa as a Modern Disease
Authors: Natalie Shainess
Journal: JAMA (1988)

<i>Fasting Girls</i>is one of a spate of books appearing in recent years on eating disorders, and especially anorexia nervosa. What is unique, however, is that its author, a historian and director of women's studies and family development, offers a sociohistorical survey. In examining theoretical models of anorexia, Brumberg cites Hilde Bruch, giving a concise and accurate viewpoint in a single paragraph. To me, Bruch had perhaps the clearest formulation on anorexia of anyone, yet there appears perhaps just the faintest critical tone in relation to it. Yet there is accuracy in the recognition that no single psychological model is complete. Brumberg turns to the cultural model and the cultural imperative of slimness as an attribute of female beauty. Wisely, she rejects the concept of free choice in anorexia, thus allowing for unconscious factors. To those uninformed about medieval Europe, it is interesting to learn that many woman saints ate
EAACI position paper: skin prick testing in the diagnosis of occupational type I allergies
Authors: V. van Kampen, F. de Blay, I. Folletti, P. Kobierski, G. Moscato, M. Olivieri, S. Quirce, J. Sastre, J. Walusiak‐Skorupa, M. Raulf‐Heimsoth
Journal: Allergy (2013)

Abstract Skin prick testing (SPT) in combination with the clinical history of the patient is one important step in the diagnosis of IgE‐mediated occupational allergies. However, skin test performance is related to the quality of allergen extracts. The present consensus document was prepared by an EAACI Task Force consisting of an expert panel of allergologists and occupational physicians from Germany, Italy, Spain, France, Austria, and Poland. All members of the panel were also involved in the data collection within the European multicentre study STADOCA ( Sta ndard d iagnosis for oc cupational a llergy). The aim of this Task Force was the assessment of the quality of commercially available SPT solutions for selected occupational allergens under standardized procedure conditions in different European centres and institutes of Occupational Medicine. The data evaluation shows a wide variability among SPT solutions and also indicates that the sensitivity of several SPT solutions is low. Therefore, improvement and standardization of SPT solutions for occupational allergens is highly recommended. Clinical practitioners should also not presume that their SPT solutions are fully reliable. The main objective of the document is to issue consensus suggestions for the use of SPT with occupational allergens based on the European multicentre study STADOCA, on existing scientific evidence and the expertise of a panel of allergologists.
Planar and SPECT Tc-99m Red Blood Cell Imaging in Hepatic Cavernous Hemangiomas and Other Hepatic Lesions
Authors: CHARLES INTENZO, SUNG KIM, MARK MADSEN, ANIL DESAI, CHAN PARK
Journal: Clinical Nuclear Medicine (1988)

The utility of Tc-99m RBC imaging in the diagnosis of hepatic cavernous hemangiomas has been established. Of the 25 patients with various focal hepatic lesions evaluated, 16 were diagnosed as having hemangiomas: eight proven by surgery, two proven by angiography, and six proven by maintaining a stable clinical course ranging from 6 to 12 months with normal follow-up liver function tests. Although fourteen of these were detected by planar imaging, two were detected by SPECT only. Two patients with large hemangiomas had false-negative scans, whereas the remaining seven patients had other liver lesions.
CB-07 * DISTINCT RADIATION RESPONSE OF SLOW-DIVIDING CANCER STEM CELLS
Authors: L. Deleyrolle, N. Nabilsi, B. Griffith, N. Pasternack, K. Dajac, J. Patel, M. Rohaus, A. Harding, M. Kladde, D. Steindler, B. Reynolds, F. Siebzehnrubl
Journal: Neuro-Oncology (2014)

Glioblastoma, the most frequent primary malignancy of the central nervous system, is almost universally fatal despite aggressive therapies, such as surgical resection, adjuvant radiation and chemotherapy, which remain largely palliative. With increasing evidence showing that glioblastoma cancer stem cells play an important role in tumor escape from conventional therapies and disease recurrence, the targeting of cancer stem cells with different therapeutic strategies provides new avenues of research and confidence for better outcomes. We have previously shown that isolating slow-dividing cells from glioblastoma enriches for a population with cancer stem cell properties. Here, we demonstrate that these slow-dividing cancer stem cells are more invasive and more tolerant to chemotherapy than the rest of the tumor population. Surprisingly, slow-proliferating cells are initially more sensitive to radiation damage. We find a significant overlap between the slow-proliferating compartment and expression of the transcription factor ZEB1, which we have recently identified as a master regulator of stemness and chemoresistance in glioblastoma. Consequently, ZEB1-positive cells also exhibit greater radiosensitivity. Slow proliferating, ZEB1-positive cells accumulate genomic aberrations correlated with retention in the G2/M phase of the cell cycle, rendering these cells more sensitive to radiation damage. However, from this specific subpopulation, a fraction of cells that survive irradiation rebound with a proliferative burst that may contribute to recurrence of more aggressive tumors. This distinct effect of radiation on cancer stem cells points to a previously underappreciated heterogeneity within the cancer stem cell compartment and may open up new avenues of studying and targeting specific cancer stem cell sub-populations.