tbuckley/cabot-search huggingface dataset:
The Nature and Treatment of Depression
Authors: Martin R. Lipp
Journal: JAMA (1975)

Anyone familiar with current psychiatric literature might believe that half the population are depressed and the other half are writing about being depressed. The two groups clearly are not mutually exclusive. This particular book has several assets in what is obviously a competitive field: it's intended for the practicing clinician and manages to be substantive without being ponderous. The editors have gathered competent contributors from all over the United States and one from Britain. The approach is proudly eclectic, drawing together many diverse perspectives into a current, readable, and reasonably cohesive overview of the subject. Of the volume's 20 chapters, six focus on treatment, five on current research, three on etiologic theories (psychodynamic, interpersonal, environmental) and three on age-related depressions (childhood, adolescence, old age). The remainder presents the argument underlying the editors' eclectic approach, a review of historical concepts of depression, and a discussion of unipolar and bipolar affective states.
Treatment of Stasis Ulcers
Authors: John V. Waller
Journal: JAMA (1963)

To the Editor:  —In Dr. Linton's answer to the question on treatment of stasis ulcer which appears in the Nov 24 issue ofThe Journal( 182: 885), there are two items with which I disagree and a third which is not mentioned.   In my experience, antibiotics as local treatment for varicose ulcers should never be used, since local allergy frequently develops. Systemic allergy or atopic dermatitis are other complications. Furthermore, local antibiotic therapy is never needed.  An adequate compression dressing, tightly applied, as mentioned by Dr. Linton, will certainly promote the healing of any stasis ulcer, provided that local inflammation and tenderness do not preclude the use of adequate pressure. Many patients, when first seen, have so much inflammation and tenderness in the region of the ulcer that they must be placed at bed rest with the legs elevated above heart level. Boric acid or Burow's solution wet dressings may
Bristol again: (Very) short service on the Bristol inquiry
Authors: N. Barnes
Journal: BMJ (1998)

# Bristol again {#article-title-2}

This week we publish three further articles about the issues raised by the Bristol affair. The first, by Nick Barnes, is a personal account of his first being invited, and then having his invitation withdrawn, to join the public inquiry into the management of children receiving complex cardiac surgical services at the Bristol Royal Infirmary in 1984-95.

The next two pieces, one by Steve Bolsin, the “whistleblower” in the Bristol case, and the second by James Stewart, a parent of one of the affected children, respond to a previous article by Peter Dunn (24 October, p 1144)—as do three letters in our correspondence columns (pp 1592-3) and a personal view (p 1603).

We do not intend to conduct the public inquiry in the pages of the BMJ , but we are publishing these articles now because one raises questions about the composition of the inquiry panel and the others respond directly to Dunn's article: see also our editorial by Smith. We will report on the progress of the Bristol inquiry when it starts taking evidence next year.

# (Very) short service on the Bristol inquiry {#article-title-3}

The following is an annotated extract from a personal journal of recent months. Events are recorded in normal type and contemporary thoughts and commentary in italics.

The prolonged hearing of the disciplinary committee of the General Medical Council on the doctors charged with professional misconduct in the Bristol paediatric cardiac surgery unit concludes at last. The media coverage has been extensive, simplistic, and condemnatory. The cardiac surgeons, Mr James Wisheart and Mr Janardin Dhasmana, and the then chief executive of the trust, Dr John Roylance, are found guilty. They need police protection as they leave the hearing.

I suppose all doctors must share the deep sympathy I feel for these men. I cannot remember meeting a single doctor who was not trying …
A common factor in hypertrophic osteoarthropathy
Authors: K. B. Carroll, L. Doyle
Journal: Thorax (1974)

<b>Carroll, K. B. and Doyle, L. (1974).</b><i>Thorax</i>, <b>29</b>, 262-264. <b>A common factor in hypertrophic osteoarthropathy.</b> Two cases of oesophageal disease with hypertrophic osteoarthropathy are presented. The unusual site of the primary lesion has prompted a review of the literature and led to the conclusion that there is a common innervation accounting for a common afferent arc which is an integral and basic part of the mechanism in this disorder.
Forewarnings of Illness: Predictions and Premonitions in Cancer Patients
Authors: JOHN R. LION, THOMAS P. HACKETT
Journal: American Journal of Psychiatry (1968)

One hundred patients in a tumor clinic were asked if they had experienced forewarnings of their illness. Thirteen responded positively. Two said they had been "cursed," four had premonitions, and seven had been told by others they would develop this illness. Only five of the 13 considered the possibility of a direct relationship between the forecast and the illness.
Regional Variations in Plasma Fibrinogen
Authors: Donald E. McMillan, John I. Malone
Journal: Annals of Internal Medicine (1992)

Letters15 March 1992Regional Variations in Plasma FibrinogenDonald E. McMillan, MD, John I. Malone, MDDonald E. McMillan, MDSearch for more papers by this author, John I. Malone, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-6-521 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Ernst (1) raised an important point about plasma fibrinogen measurement, a test used in cardiovascular risk factor assessment (2). In agreement with a past report (3), he compared fibrinogen measurements from several sources to indicate that fibrinogen values can be affected by geographic and climatic considerations. We have recently made observations in type I diabetes that bear directly on his conclusion. They have been used to test whether geographic or climatic factors, or both, actually influence fibrinogen level. Our observations suggest that the geographic-climatic problem he raises is not a large one; measurement differences between laboratories and...References1. Ernst E. Regional variations in plasma fibrinogen levels. Ann Intern Med. 1991;115:329-30. LinkGoogle Scholar2. KannelDagostinoBelanger WRA. Fibrinogen cigarette smoking and risk of cardiovascular disease insights from the Framingham study. Am Heart J. 1987;113:1006-10. CrossrefMedlineGoogle Scholar3. Tromp S. Influence of weather and climate on the fibrinogen content of human blood. Int J Biometeor. 1972;16:93-5. CrossrefMedlineGoogle Scholar4. . The diabetes control and complications trial (DCCT): results of the feasibility study and design of the full-scale clinical trial. Pediatr Adolesc Endocrinol. 1989;18:15-21. Google Scholar5. LeeSmithLoweTunstall-Pedoe AWGH. Plasma fibrinogen and coronary risk factors: the Scottish heart health study. J Clin Epidemiol. 1990;43:913-9. CrossrefMedlineGoogle Scholar1. Ernst E. Regional variations in plasma fibrinogen levels. Ann Intern Med. 1991;115:329-30. LinkGoogle Scholar2. SkovborgNielsenSchlichkullDitzel FAJJ. Blood viscosity in diabetic patients. Lancet. 1966;1:129-31. CrossrefMedlineGoogle Scholar3. MatraiErnst AE. Platelets and coronary heart disease. Br Med J. 1985;290:934. CrossrefGoogle Scholar4. ErnstMatrai EA. Pitfalls in blood sampling-influence of posture and venous occlusion time. Haematologica. 1986;71:263-5. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of South Florida Tampa, FL 33612 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1992Volume 116, Issue 6Page: 521-522KeywordsBlood plasmaFibrinogenMedical risk factors Issue Published: 15 March 1992 PDF DownloadLoading ...
DNA on Trial — The Molecular Basis of DNA Fingerprinting
Authors: D E Housman
Journal: New England Journal of Medicine (1995)

The use of direct DNA-based testing in forensic analysis has become increasingly common. In the past, genetic identity or similarity could be inferred by comparison of ABO blood groups and other protein-based measurements. These measures are sufficiently variable within the population to permit a reasonable test of identity between different samples. However, there are two major advantages to direct DNA testing. First, it makes use of many more variables, thus strengthening the significance of a match between specimens. Second, the physical stability of DNA makes it possible to analyze minute amounts of forensic material many years after a criminal incident. . . .
UK has highest reduction in deaths from lung and breast cancer
Authors: C. McKenna
Journal: BMJ (2002)

The United Kingdom has seen the highest reduction in the world in the rates of death from female breast and male lung cancer, according to the latest research from Oxford University professors Richard Doll and Richard Peto, presented at the headquarters of Cancer Research UK last week.

Total cancer mortality for both males and females is at its lowest levels since 1950, said Professor Peto. The figures were heavily influenced by the decrease in cancers attributed to smoking.

In males, cancer deaths not attributed to …
Should smokers be advised to cut down as well as quit?
Authors: P. Aveyard, N. Lindson-Hawley, G. Hastings, M. de Andrade
Journal: BMJ (2014)

<b>Paul Aveyard</b> and <b>Nicola Lindson-Hawley</b> say that reducing smoking is a worthwhile step towards cessation, but <b>Gerard Hastings</b> and <b>Marisa de Andrade</b> argue that the lifelong nicotine replacement therapy being recommended in support may benefit industry more than public health
Cowpersons Is Milkpersons
Authors: Christopher A. Moeller
Journal: JAMA (1986)

<h3>To the Editor.—</h3> I was aghast to read the assertion by Dr John A. Churchill<sup>1</sup>in a recent letter published in<i>JAMA</i>that the possible explanation for lack of reported cases of milk sickness in humans<sup>2</sup>may be due to the fact that "cowboys don't drink much milk." I can speak from my own experience tending cattle back in my native state of Oklahoma that not only do I drink milk, but I consume much more than I do when I'm in North Carolina tending my residency duties. This discrepancy prompted an informal telephone survey, by myself, of cowboy and cowgirl acquaintances in Oklahoma and Texas. The results were no surprise to me. The mean consumption of milk in one form or another varied from 2 to 8 L per cowperson per week. This rivals if not exceeds the weekly milk consumption of the typical city dweller and
An "Upside-Down" Liver and Gallbladder Discovered on Hepatobiliary Scan
Authors: DANIEL W. D'AMATO, HELENA R. BALON, PAUL J. ARPASI
Journal: Clinical Nuclear Medicine (1999)

An ectopic gallbladder that mimicked a possible neoplasm on CT is described. Ultrasound failed to visualize the gallbladder. These findings were finally explained by the hepatobiliary scan, which showed the gallbladder to be in an ectopic location near the hepatic dome.
Vitamin E (d-alpha-tocopheryl-co-poly(ethylene glycol) 1000 succinate) micelles-superparamagnetic iron oxide nanoparticles for enhanced thermotherapy and MRI
Authors: Prashant Chandrasekharan, Dipak Maity, Cai Xian Yong, Kai-Hsiang Chuang, Jun Ding, Si-Shen Feng
Journal: Biomaterials (2011)
Apelin protects sarcoplasmic reticulum function and cardiac performance in ischaemia-reperfusion by attenuating oxidation of sarcoplasmic reticulum Ca2+-ATPase and ryanodine receptor
Authors: Chen Wang, Nan Liu, Ronghua Luan, Yan Li, Dongjuan Wang, Wei Zou, Ying Xing, Ling Tao, Feng Cao, Haichang Wang
Journal: Cardiovascular Research (2013)

AimsApelin, an endogenous cytokine, has a number of biological effects on the cardiovascular system, including a cardioprotective effect and calcium modulation. Because the intracellular calcium abnormality is considered to play an important role in cardiac dysfunction induced by ischaemia–reperfusion (I/R), the aim of this study was to examine the effects of apelin-13 on I/R-induced changes in cardiac performance and sarcoplasmic reticulum (SR) function.
Atlas and Epitome of Diseases of the Mouth, Pharynx, and Nose.
Authors: Ludwig Grunwald, James E Newcomb
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of poly(l-lysine)-modified Fe3O4 nanoparticles on endogenous reactive oxygen species in cancer stem cells
Authors: Xueqin Wang, Qin Tu, Bin Zhao, Yanfei An, Jian-Chun Wang, Wenming Liu, Mao-Sen Yuan, Saeed Mahmoud Ahmed, Juan Xu, Rui Liu, Yanrong Zhang, Jinyi Wang
Journal: Biomaterials (2012)
LYMPHOSARCOMA OF THE SMALL INTESTINE
Authors: THOMAS H. KELLEY
Journal: JAMA (1924)

The comparative rarity of lymphosarcoma of the intestine prompts me to report a case that came under my observation some months ago. <h3>REPORT OF CASE</h3> The patient, a woman, unmarried, aged 34, was admitted to the Illinois Central Hospital, Jan. 24, 1923, with a history of pain in the epigastrium and lower left quadrant. The onset occurred seven weeks previously with sudden, cramplike pain over the entire abdomen. A physician who was called prescribed a cathartic, which, however, gave no relief. The pain gradually decreased in severity and finally localized as a dull pain in the left lower quadrant. The patient was nauseated at the onset but did not vomit. Bowel movement had no influence on the pain. The history was otherwise unimportant. On examination a hard, irregular mass was palpable superficially at the level of the navel on the left side. The mass extended downward to the lower quadrant,
Treatment of the Obese Patient
Authors: Johanna T. Dwyer, Jean Mayer
Journal: Annals of Internal Medicine (2008)

Medical Writings: Book Notes20 May 2008Treatment of the Obese PatientJohanna T. Dwyer, DSc, RD and Jean Mayer, USDAJohanna T. Dwyer, DSc, RDFrom Tufts Medical Center Schools of Medicine and Human Nutrition Research Center on Aging, Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts.Search for more papers by this author and Jean Mayer, USDAFrom Tufts Medical Center Schools of Medicine and Human Nutrition Research Center on Aging, Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-10-200805200-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Treatment of the Obese PatientKushner RF, Bessesen DH, eds. 444 pages. Totowa, NJ: Humana; 2007. $135.00. ISBN 978159745400. Order at www.springer.com/humana.Field of medicine: Clinical nutrition.Format: Hardcover book.Audience: Endocrinologists, internists, and family physicians.Purpose: To inform clinicians about recent advances in obesity research and provide an up-to-date review of current issues and strategies in obesity treatment.Content: The first part of the book is a brief and readable but authoritative review of key concepts on the control of body weight and the pathophysiology of obesity, with an eye on the needs of clinicians. The new endocrinology of ... Author, Article, and Disclosure InformationAffiliations: From Tufts Medical Center Schools of Medicine and Human Nutrition Research Center on Aging, Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 May 2008Volume 148, Issue 10Page: 796KeywordsBioenergeticsBody weightNutritionObesityOvariesOverweightPatientsScience policySoftware toolsSurgery ePublished: 20 May 2008 Issue Published: 20 May 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Interleukin 1 suppresses inflammation in rabbit colitis. Mediation by endogenous prostaglandins.
Authors: F Cominelli, C C Nast, R Llerena, C A Dinarello, R D Zipser
Journal: Journal of Clinical Investigation (1990)

Pretreatment with low-dose IL-1 has protective effects in animal models of inflammation or tissue injury, but the mechanisms of these protective effects are not established. To determine if prostaglandins are involved, we administered human recombinant IL-1 beta and measured rectal PGE2 production in rabbits with formalin-immune complex colitis. IL-1 beta (0.3 micrograms/kg) administered 24 h before induction of colitis increased PGE2 (231 +/- 36 to 1,299 +/- 572 pg/ml, P less than 0.01) and reduced subsequent inflammatory cell infiltration index (from 2.8 +/- 0.3 to 1.4 +/- 0.3, P less than 0.02) and edema (from 2.5 +/- 0.3 to 1.3 +/- 0.3, P less than 0.01) compared with vehicle-matched animals. Administration of ibuprofen (10 mg/kg i.v.) together with IL-1 beta prevented the stimulation of PGE2 and the reduction in inflammation. Colonic PGE2 production correlated inversely with subsequent severity of inflammation (P less than 0.02, r = -0.39) and edema (P less than 0.04, r = -0.35). IL-1-administration 30 min before induction of colitis did not affect the severity of inflammation. Similarly, pretreatment with a noninflammatory synthetic peptide (fragment 163-171) of human IL-1 beta, either 30 min or 24 h before colitis induction, did not reduce inflammation or increase prostaglandin synthesis. These data demonstrate that pretreatment with IL-1 beta 24 h before the induction of colitis reduces inflammation by a mechanism that requires prostaglandin synthesis.
Screening for Unruptured Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney Disease
Authors: David O. Wiebers, Vicente E. Torres
Journal: New England Journal of Medicine (1992)

The association of intracranial aneurysms with autosomal dominant polycystic kidney disease and the 30-day mortality rate of more than 50 percent among patients with aneurysmal rupture1 have led physicians to consider the value of screening patients with this disease for unruptured aneurysms. Ultimately, the value of such screening depends on the yield of the screening procedure and the likelihood that the patient will benefit from treatment if an aneurysm is found. The value of treatment is further dependent on the risk inherent in the screening technique, the natural history of unruptured intracranial aneurysms, and the risk—benefit ratio for interventional therapy. . . .
Accumulation modes of alkylating agents on normal peripheral blood lymphocytes
Authors: Jerome I. Brody
Journal: American Journal of Hematology (1978)

Abstract The in vitro uptake by normal peripheral blood lymphocytes of 14 C‐labeled cyclophosphamide and nitrogen mustard has been measured in a manner which parallels cell exposure to drugs used in the nitrogen mustard‐oncovin‐procabazine‐prednisone (MOPP) and cyclophosphamide‐oncovin‐procarbazine‐prednisone (COPP) clinical protocols. Accumulation of these alkylating agents occurs in two recognizable patterns. The first exhibits a saturation phenomenon, since radioactivity can be partially blocked by an equal concentration of unlabelled drug, reflects stereospecificity, and represents a minor fraction of total deposition. The second form, proportionately larger than the first, is dependent on drug concentration in the suspending medium, with radioactivity increasing in an apparently limitless linear fashion, uninfluenced by competitive inhibition. This part also is less tenaciously held by the lymphocyte. While the mere presence of drug on the lymphocytes does not necessarily imply injury or lethality, the fact that these peripheral lymphocytes are able to accumulate cytotoxic agents and are partially interchangeable with an analogous fixed lymphoid cell mass suggests that clinical immunosuppression and lymphocytopenia may be related, in part, to cell drug deposition.
HLA-DR3 in dermatitis herpetiformis
Authors: HUBERT PEHAMBERGER, KARL HOLUBAR, WOLFGANG R. MAYR
Journal: British Journal of Dermatology (1981)

Twenty-one patients with dermatitis herpetiformis were typed for HLA-ABC and -DR determinants. The incidence of HLA-AI, -B8 and -DR3 antigens was found to be significantly higher (P: = 10−3, <10−6 and <10−6, respectively) among patients with dermatitis herpetiformis than among the normal population. HLA-DR3 was found in 85.7% of patients, HLA-B8 in 66.7% and HLA-Ai in 61.9% only. These results indicate that HLA-DR3 is the antigen primarily associated in dermatitis herpetiformis and the latter antigens (HLA-Ai and -B8) are present in increased incidence, probably due to the known linkage disequilibrium of these antigens with HLA-DR3.
Eosinophil traffic in the circulation following allergen challenge
Authors: L. A. Sklar, H. Tsuji, B. S. Edwards, R. S. Larson, M. Schuyler
Journal: Allergy (2004)

Eosinophils contribute to the pathogenesis of asthma and localize to the lung after allergen exposure by uncertain mechanisms.We used intrabronchial instillation of allergen to model the interaction between inhaled allergen and the lung. We measured the number of peripheral blood leukocytes and the expression of VLA-4 (CD49d), Mac-1 (CD11b) and PSGL-1 (CD162) up to 4 h after instillation of allergen into a bronchus of eight atopic asthmatics. For controls, we instilled normal saline into a subset of the asthmatic subjects, and allergen into nonatopic, nonasthmatic subjects.There were changes of total leukocyte number, number of polymorphonuclear leukocytes, lymphocytes, monocytes and eosinophils in all three groups (atopic asthmatics instilled with allergen, atopic asthmatics instilled with saline, nonatopic nonasthmatic subjects instilled with allergen), which were likely related to bronchoscopy. However, the decrease of eosinophils was significant only in the atopic asthmatics instilled with allergen. The remaining eosinophils in the allergen challenged asthmatics were not activated as defined by cell density or change of expression of VLA-4, Mac-1 and PSGL-1.While eosinophils rapidly and specifically leave the circulation after allergen challenge of atopic asthmatics, the remaining circulating eosinophils are not activated.
The Woman Manual: The Practical Step-by-Step Guide to Women's Health for Men
Authors: Paul Grant, Clare Ilsley
Journal: BMJ (2004)

S he Being Brand New is a clever metaphorical poem by E E Cummings that compares the seduction of a woman to the starting of a new car. The publishers of the Haynes motoring manuals have devised an “operating” health guide for every make, model, and colourof woman. It is the latest in a line of health awareness titles, including the Man, Cancer, Sex and Baby manuals, and aims to help men find out what is under the bonnet of these mysterious creatures. Traditionally, men have a poor …