tbuckley/cabot-search huggingface dataset:
Blood pressure modulation by central venous pressure and respiration. Buffering effects of the heart rate reflexes.
Authors: J K Triedman, J P Saul
Journal: Circulation (1994)

Despite constant fluctuations in cardiac preload caused by the effects of respiration and changes in posture on venous return to the heart, arterial blood pressure remains remarkably constant. The effects of instantaneous lung volume (ILV) and variations of central venous pressure (CVP) on blood pressure (BP) were studied by use of frequency domain techniques to quantify the contribution of heart rate (HR) reflexes to attenuation of the effects of changes in right ventricular preload on arterial pressure.Random independent variation of ILV, then CVP (obtained using lower-body negative pressure), was performed in eight humans in the supine position. HR, ILV, CVP, and systolic (SBP) and diastolic (DBP) BPs were recorded during control periods and after complete blockade obtained by use of 0.04 mg/kg atropine and 0.2 mg/kg propranolol. A frequency-domain analysis was performed on pairwise relations by the cross-spectral technique. During autonomic blockade, fluctuations in CVP were induced up to 0.14 Hz but caused corresponding changes in arterial pressure only up to 0.08 Hz (P < .02), indicating a mechanical damping effect of the heart and pulmonary vasculature. Fluctuations of BP were also delayed from CVP by 1.55 to 2.10 seconds. At frequencies < 0.1 Hz, relations of CVP to all indices of BP increased with blockade (CVP-SBP, 0.9 +/- 0.5 versus 2.7 +/- 0.8 mm Hg/mm Hg, P < .01; CVP-DBP, 1.3 +/- 0.4 versus 4.3 +/- 1.4 mm Hg/mm Hg, P < .01; CVP-pulse pressure [PP], 1.0 +/- 0.3 versus 1.9 +/- 0.8 mm Hg/mm Hg, P < .05). Higher-frequency fluctuations of arterial BP were a relatively pure manifestation of respiratory activity. At frequencies from 0.15 to 0.35 Hz, the relation of ILV to SBP was unchanged with blockade, whereas relations of ILV to DBP and PP decreased (ILV-DBP, 6.1 +/- 3.5 versus 3.3 +/- 2.2 mm Hg/L, P < .02; ILV-PP, 7.0 +/- 4.3 versus 2.7 +/- 2.2 mm Hg/L, P < .01). An associated change in phase of these relations suggested that neurally mediated changes in HR may offset mechanical effects caused by respiration.Both slow changes of BP (< 0.08 Hz) induced by variations of CVP and more rapid changes induced by ILV are actively buffered by heart rate reflexes. During blockade, the mechanical properties of interposed cardiopulmonary structures limit CVP-induced fluctuations of BP. These findings have implications for BP regulation in pathological conditions associated with impairment of HR control.
CD-20 expression in post-transplant lymphoproliferative disorders: Treatment with Rituximab
Authors: J.J. Ifthikharuddin, L.A. Mieles, J.D. Rosenblatt, C.K. Ryan, D.M. Sahasrabudhe
Journal: American Journal of Hematology (2000)

B-cell lymphoproliferative disorders are rare but serious complications of solid organ and bone marrow transplantation. We report that these tumors frequently express the CD-20 antigen, and immunotherapy directed at this antigen may be a well-tolerated and effective treatment. Am. J. Hematol. 65:171–173, 2000. © 2000 Wiley-Liss, Inc.
Thyrotoxicosis Resembles Lyme Disease
Authors: Carolyn B. Becker, David H. Trock
Journal: Annals of Internal Medicine (1991)

Letters15 May 1991Thyrotoxicosis Resembles Lyme DiseaseCarolyn B. Becker, MD, David H. Trock, MDCarolyn B. Becker, MDSearch for more papers by this author, David H. Trock, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-10-914_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: The diagnosis of Lyme disease rests on both clinical (1) and serologic (2) findings. Patients living in endemic areas, however, may be treated for Lyme disease despite negative serologic findings. We have recently seen three such patients who actually suffered from undiagnosed thyrotoxicosis.Patient 1. A healthy 41-year-old man had a 2-month history of excessive fatigue, malaise, profound proximal muscle weakness, and bilateral burning hip and thigh pains, preceded by a flu-like illness with fever and sore throat. He lived in a wooded, deer-infested area of Connecticut. A 2-week course of antibiotics for presumed Lyme disease did...References1. Steere A. Lyme disease. N Engl J Med. 1989;321:586-96. CrossrefMedlineGoogle Scholar2. CraftGrodzickiSteere JRA. Antibody responses in Lyme disease: evaluation of diagnostic tests. J Infect Dis. 1984;149:789-95. CrossrefMedlineGoogle Scholar3. KaminskiRuff HR. Neurological complications of endocrine diseases. Neurol Clin. 1989;7:489-508. CrossrefMedlineGoogle Scholar4. SwansonKellyMcConahey JJW. Neurologic aspects of thyroid dysfunction. Mayo Clin Proc. 1981;56:504-12. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Carolyn B. Becker, MD; David H. Trock, MDAffiliations: Danbury Hospital Danbury, CT 06810 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCoexisting Thyroiditis and Carditis in a Patient With Lyme Disease: Looking for a Unifying DiagnosisFalse-positive seroreactivity to Borrelia burgdorferi in a patient with thyroiditisEfficacy of a long-term antibiotic treatment in patients with a chronic Tick Associated Poly-organic Syndrome (TAPOS)Foreword 15 May 1991Volume 114, Issue 10Page: 914-915KeywordsAntibioticsFatigueFeversHipLyme diseaseMusclesMyalgiaPainPharyngitis ePublished: 1 December 2008 Issue Published: 15 May 1991 PDF downloadLoading ...
Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens.
Authors: W E Biddison, P E Rao, M A Talle, G Goldstein, S Shaw
Journal: The Journal of Experimental Medicine (1982)

A recently described HLA gene, SB, which maps between GLO and HLA-DR, codes for Ia-like molecules that are similar to but distinct from HLA-DR molecules. Cytotoxic T lymphocytes (CTL) specific for SB1, SB2, SB3, and SB4 were compared with HLA-A2-specific CTL with respect to their surface expression of the T cell differentiation antigens OKT3, OKT4, and OKT8. All CTL activity was eliminated by treatment with OKT3 and C'. The SB-specific cytotoxicity was eliminated by OKT4 plus C' but not by OKT8 plus C'. In contrast, HLA-A2-specific killing was completely susceptible to treatment with OKT8 plus C' but not with OKT4 plus C'. Cytotoxicity was analyzed in the presence of OKT8 and a series of monoclonal antibodies (OKT4A, 4B, 4C, and 4D) that react with distinct epitopes on the OKT4 molecule. SB1-, SB3-, and SB4-specific CTL were partially inhibited by OKT4A and 4B (45-75%), whereas HLA-A2-specific CTL were partially inhibited by OKT8 (48-63%) but not by OKT4. SB2-specific CTL were not inhibited (less than 26%) by OKT8 or by any of the OKT4-related antibodies. These results suggest that the OKT4 marker may be expressed on most T cells that recognize allogeneic Ia or self Ia plus foreign antigens; OKT4+ cells do not appear to be functionally homogeneous in that they can act both as helper/inducer and cytotoxic cells. Models are proposed for the functional involvement of the OKT4 molecule in T cell-Ia antigen interactions.
452 TREATMENT ADHERENCE AND ERITHROPOIETIN USE DURING ANTIVIRAL THERAPY IN RECURRENT HEPATITIS C: A “DÉJÀVUE”
Authors: V. Aguilera, M. Prieto, A. Rubín, F. Gentili, C. Ortiz Cantó, B. Risalde, M. Berenguer
Journal: Journal of Hepatology (2010)
Localized, non-viral delivery of nucleic acids: Opportunities, challenges and current strategies
Authors: Oliver Germershaus, Kira Nultsch
Journal: Asian Journal of Pharmaceutical Sciences (2014)

Localized delivery of drugs is an emerging field both with regards to drug delivery during disease as well as in tissue engineering. Despite significant achievements made in the last decades, the efficient delivery of proteins and peptides remains challenging, especially in cases requiring long-term release of proteins after application. The localized delivery of nucleic acids (NA) represents an interesting alternative due to higher physicochemical stability of NA, increased efficiency by harnessing cells as bioreactors for the production of required proteins and improved versatility with regards to expression of specific proteins through plasmid DNA or repression of gene products through siRNA. However, unlike most proteins and peptides, NA must be delivered to the cytoplasm or nucleus to be efficacious, resulting in significant delivery challenges. We herein describe frequently used non-viral vectors for the delivery of NA including polyplexes, lipoplexes and lipopolyplexes and summarize recent developments in the field of nucleic acid delivery systems for local application based on hydrogels, solid scaffolds and physical delivery methods. The challenges associated with the different approaches are identified and options to address these challenges are discussed.
Immunohistochemical demonstration of proteoglycans in the skin of patients with systemic sclerosis
Authors: M. KITABATAKE, H. ISHIKAWA, H. MAEDA
Journal: British Journal of Dermatology (1983)

Skin proteoglycan was demonstrated by an immunofluorescent technique using an antibody against bovine cartilage proteoglycan, after the cross‐reactivity of human proteoglycan with the antiserum had been confirmed. Normal skin exhibited specific fluorescence mainly in the blood vessels as well as in the subepidermal area. The clinically uninvolved skin of systemic sclerosis (SS) revealed no features different from those of normal skin. However, the vascular proteoglycan deposition of early systemic sclerosis was later replaced by deposition between the collagen fibres, which appeared to progress centrifugally in parallel to the increase in the skin sclerosis, suggesting a vascular initiation of the skin lesion. Sclerotic skin was characterized by random deposition between the collagen fibres. Immunoelectron microscopic studies suggested that the random proteoglycan deposition reflected uncontrolled local accumulation of proteoglycan in the interfibrillar matrix around irregularly arranged collagen fibrils.
INCIDENTAL DETECTION OF MALIGNANCY AND OTHER NON-CARDIOVASCULAR ABNORMALITIES ON MULTISLICE COMPUTED TOMOGRAPHY IN PATIENTS WITH SEVERE AORTIC STENOSIS EVALUATED FOR TRANSCATHETER AORTIC VALVE IMPLANTATION
Authors: Itsik Ben-Dor, Ron Waksman, Nicholas N. Hanna, Arnold Raizon, Lowell F. Satler, Rebecca Torguson, Gaby Weissman, Petros Okubagzi, Zhenyi Xue, Yanlin Li, Manuel A. Gonzalez, Michael A. Gaglia, Gabriel Maluenda, Kohei Wakabayashi, Cedric Delhaye, Asmir I. Syed, Sara D. Collins, William O. Suddath, Kenneth M. Kent, Joseph Lindsay, Augusto D. Pichard
Journal: Journal of the American College of Cardiology (2010)
Watching the Monitors: “PAID” Prescriptions, Fiscal Intermediaries and Drug-Utilization Review
Authors: John P. Morgan
Journal: New England Journal of Medicine (1977)

Prescription monitoring evolved from the need of drug firms to obtain marketing information. Today, extensive monitoring is also done by fiscal intermediaries who administer prepaid drug benefit plans, both private and governmental, particularly Medicaid. The most important such agent is PAID Prescriptions. Under various contracts, PAID monitors physician, pharmacy, and patient behavior related to prescriptions and uses review processes that evaluate certain kinds of behavior for appropriateness. The criteria of appropriateness are essentially those that save money. PAID negotiates a program fee with the insurer (public or private) and applies constraints so that prescription and administrative costs do not overrun that fee. PAID and other monitors have contemplated expansion into the realm of defining and encouraging appropriate prescribing under the concept of "drugutilization review." The actual practices of PAID, particularly the background of fiscal enforcement, may impede the development of an actual drug-utilization review process.
Computed Tomography Screening for Lung Cancer
Authors: Christine D. Berg, Denise R. Aberle
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nonfatal Human Ingestion by a B-58 Jet Engine
Authors: Richard H. Fallon
Journal: JAMA (1966)

AIRCRAFT ground crews are being exposed to a new danger as jet aircraft replace propeller aircraft in both civilian and military use. The danger of the whirling propeller has been replaced by the suction of the jet intake, the so-called jet-engine ingestion injury. The only report to my knowledge of this type of injury has been from the US Air Force.<sup>1</sup>In that report the actual type of injuries was not given. For this reason the following case is presented. <h3>Report of a Case</h3> A 19-year-old airman third class with jet-aircraft experience was sucked into the engine of a B-58 ("Hustler") while the engines were being trimmed at 90% rpm. The engine was immediately shut down, and two other airmen pulled the victim from the engine. Immediate mouth to mouth resuscitation was administered by one of the rescuers, as the victim was apneic. The victim was brought to the
Gall-stone dissolution and recurrence: are we being misled?
Authors: K W Somerville, D H Rose, G D Bell, W R Ellis, D R Knapp
Journal: BMJ (1982)

Oral cholecystography repeated at six-months intervals is the standard method for determining reduction in size of gall stones (partial success) and complete dissolution of stones (complete success). In a comparative study of oral cholecystography and cholecystosonography six out of 14 patients with gall stones achieving complete success by oral cholecystographic criteria had stones still detectable by ultrasonography. Repeat oral cholecystography in a further 11 patients receiving post-dissolution maintenance treatment detected stones in two, whereas ultrasonography detected stones in seven. In future complete dissolution of gall stones should be reported only if both oral cholecystography and ultrasonographic studies give negative results and the progress of patients receiving post-dissolution maintenance treatment is monitored by ultrasonography rather than serial oral cholecystography.
Hepatic hypertrophic osteoarthropathy and liver transplantation.
Authors: G Cunnane, A M O'Byrne, J Hegarty, O Fitzgerald
Journal: Annals of the Rheumatic Diseases (1994)

Hepatic hypertrophic osteoarthropathy and liver transplantationHepatic hypertrophic osteoarthropathy (HOA) is a rare and disabling condition.It tends to respond poorly to conservative management such as analgesia or intra- articular injection of steroids.A recent
An Exploratory Investigation into Types of Adult Homesickness
Authors: Miranda A.L. van Tilburg, Elisabeth H.M. Eurelings-Bontekoe, Ad J.J.M. Vingerhoets, Guus L. van Heck
Journal: Psychotherapy and Psychosomatics (1999)

It is not clear yet whether or not homesickness is a singular syndrome. Some authors have proposed different subtypes or forms of homesickness. Since there may be great differences between various subtypes of homesickness regarding etiology, causes, manifestations and consequences, a distinction of subtypes may have far-reaching implications for research and therapy. This exploratory study was conducted to find out whether homesickness can be considered a homogeneous syndrome, or whether there are distinct subtypes that differ in etiology, severity of the condition and manifestations.Thirty-one individuals, who have had severe homesickness experiences, were interviewed, and verbal scripts were typed out. Twenty-four interviews were suited for analyses. All text related to the topics most relevant to the purpose of the study was extracted. The text was first analyzed searching for meaning and categories and afterwards coded and used in a HOMALS analysis.The HOMALS analysis yielded two dimensions. The first dimension can be described as a dimension of psychopathology differentiating 'recovered' and recurrent homesickness. The second dimension was strongly dominated by homesickness during holidays.It seems that there are reasons to presume the existence of at least two subtypes of homesickness: (1) recurrent homesickness related to signs of psychopathology and recurrent homesickness experiences and (2) recovered homesickness, which can be considered as a normal adjustment problem which most people overcome. Very tentatively, a third type of homesickness might be distinguished: holiday homesickness, which is associated with difficulties in breaking with old routines. Consequences for research and therapy are discussed. Furthermore, the need of validation studies is underlined.
The American Right to Bear Arms—Reply
Authors: Lawrence O. Gostin
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serum levels of soluble stem cell factor and soluble KIT are elevated in patients with atopic dermatitis and correlate with the disease severity
Authors: T. Kanbe, Y. Soma, Y. Kawa, M. Kashima, M. Mizoguchi
Journal: British Journal of Dermatology (2001)

Mast cell infiltration in skin lesions of atopic dermatitis (AD) is considered to play an important role in the pathogenesis of the disease. The most common factor that stimulates mast cell growth, migration and differentiation is stem cell factor (SCF), and the interaction of SCF and its receptor, KIT (tyrosine kinase transmembrane receptor), appears to be the key event in the recruitment and proliferation of mast cells.To determine whether any altered metabolism of SCF and/or KIT is present in patients with AD.We measured serum levels of soluble SCF (sSCF) and soluble KIT (sKIT) using enzyme-linked immunosorbent assay in 54 patients with AD, five patients with erythrodermic psoriasis vulgaris and 64 healthy individuals.Serum levels of both peptides in AD patients were significantly higher than those in healthy individuals, whereas patients with psoriasis vulgaris did not show any difference from healthy controls. Both sSCF and sKIT levels were positively correlated with the disease severity in AD patients, and decreased after effective treatment with topical corticosteroids. Conclusion Serum levels of sSCF and sKIT may be useful indicators for evaluation of the activity and severity of AD.
TCT-417 Left Ventricular Assist Improves 90 Day Outcomes With Unprotected Left Main Coronary Intervention: Analysis From The Protect II Trial
Authors: Alan W. Heldman, Mauricio G. Cohen, Simon Dixon, Jeffrey W. Moses, Igor F. Palacios, Ashish Pershad, William W. O'Neill
Journal: Journal of the American College of Cardiology (2013)
Bone Scan Injection Artifacts
Authors: MARY P. ANDRICH, CLARA C. CHEN
Journal: Clinical Nuclear Medicine (1996)

Increased activity typically may be seen at the site of injection in bone scanning due to extravasation of tracer into surrounding soft tissues. A more unusual artifact is temporarily increased uptake in an adjacent bone proximal to the injection site. Without other areas of abnormality suggestive of metastatic disease or osteonecrosis, this finding is most likely a local phenomenon related to the extravasated radiopharmaceutical.
Does consuming isoflavones reduce or increase breast cancer risk?
Authors: Maria Bondesson, Jan-Ake Gustafsson
Journal: Genome Medicine (2010)

Epidemiological studies suggest that consumption of phytoestrogens, in particular isoflavones, correlates with a lower incidence of breast cancer. However, data from human intervention studies have been less clear. Several meta-analyses have reported beneficial but relatively weak effects of isoflavone consumption on reduction of hot flushes and osteoporosis and improvement of cholesterol levels. However, the effects of isoflavones on early breast cancer markers differ between pre- and post-menopausal women. Conclusions on whether exposure of animals (mice and rats) to isoflavones protects against or promotes breast cancer development and growth vary between different studies. These results, taken together with the heterogeneous outcomes of human interventions, have led to a controversy surrounding the intake of isoflavone to reduce breast cancer risk. Here, we describe the results of recent human and animal intervention studies and discuss factors that might explain the variation in results. We also describe possible molecular mechanisms of action of isoflavones; distinguishing which mechanism(s) are involved is needed if we are to solve the controversy surrounding the actions of these compounds.
The Promise of Satellite Clinics
Authors: John M. Nelson
Journal: JAMA (1982)

A community hospital has developed a successful model for establishing affiliated primary care centers in semirural areas without the use of federal or foundation money. Unique features of the program include funding through community stock sales and ultimate control by a community board of directors. Additional features include the establishment of a for-profit, wholly owned subsidiary of the hospital; development of a complete range of planning, management, and recruitment services; retention of freedom of choice for referrals and hospitalizations by both patients with physicians; and a but-our provision for the physicians.
Inhibitory effect of oral doxantrazole on asthma induced by allergen inhalation.
Authors: S P Haydu, J L Bradley, D T Hughes
Journal: BMJ (1975)

As this infrequent complication of proximal gastric vagotomy causes morbidity and mortality methods for its prevention should be con- sidered.Plication of the lesser curve to bury and reperitonealize the bared area may be effective.