Hypercoagulability Associated with Malignant Disease and with the Postoperative State
Authors: MELVIN A. AMUNDSEN
Journal: Annals of Internal Medicine (1963)

Article1 April 1963Hypercoagulability Associated with Malignant Disease and with the Postoperative StateEvidence for Elevated Levels of Antihemophilic GlobulinMELVIN A. AMUNDSEN, M.D., JOHN A. SPITTELL JR., M.D., JOHN H. THOMPSON JR., PH.D., CHARLES A. OWEN JR., M.D.MELVIN A. AMUNDSEN, M.D.Search for more papers by this author, JOHN A. SPITTELL JR., M.D.Search for more papers by this author, JOHN H. THOMPSON JR., PH.D.Search for more papers by this author, CHARLES A. OWEN JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-608 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe increased incidence of venous thrombo-embolism associated with malignant (1, 2) disease and with the postoperative state (3, 4) is well recognized. Although thrombophlebitis may occur in association with any malignant lesion, it is seen more frequently with cancer of certain organs, especially the pancreas, lung, stomach, and ovary (5-8). Investigation of the changes in the mechanism of blood coagulation in patients with cancer has been relatively neglected compared to the extensive investigations of the changes that follow operation (9-13) or are associated with occlusive arterial disease (14-19).The evidence for hypercoagulability in patients during the postsurgical period most consistently...References1. EDWARDS EA: Migrating thrombophlebitis associated with carcinoma. New Engl. J. Med. 240: 1031, 1949. CrossrefMedlineGoogle Scholar2. GROSSJAEHNINGCOKER FBDGWG: The association of migratory thrombophlebitis with carcinoma. North Carolina Med. J. 12: 97, 1951. MedlineGoogle Scholar3. BARKERNYGAARDWALTERSPRIESTLEY NWKKWJT: A statistical study of postoperative venous thrombosis and pulmonary embolism. I. 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Author, Article, and Disclosure InformationAffiliations: Rochester, MinnesotaFrom the Mayo Clinic and Mayo Foundation, Rochester, Minnesota.This study is an abridgment of thesis submitted by Dr. Amundsen to the Faculty of the Graduate School of the University of Minnesota in partial fulfillment of the requirements for the degree of Master of Science in Medicine.Presented at the Forty-third Annual Session of the American College of Physicians, Philadelphia, Pennsylvania, April 9-13, 1962.This investigation was supported in part by research grant H-5008 from the National Institutes of Health, Public Health Service.Dr. Amundsen was recipient of training grant HF-13,375 from the National Institutes of Health, Public Health Service.Requests for reprints should be addressed to Mayo Clinic, Rochester, Minnesota. 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