tbuckley/cabot-search huggingface dataset:
HYDRATION STATUS IN SWISS ELITE MALE JUDOKAS
Authors: M Jung, N Malliaropoulos
Journal: British Journal of Sports Medicine (2014)

Background Judo competitions are divided into weight classes. Some athletes reduce their body weight in short time in order to obtain a competitive advantage over lighter opponents. Fast weight loss comprises dehydration strategies that could place the athletes at health risk. Since nutrition is often the missing piece in the athlete's knowledge, the judoka is not aware of the risk taken. Hypohydration leads to a diminution of function and so has many negative effects on health (musculoskeletal and neurological). Objective To assess the feasibility of a Bioelectrical Impedance Analysis (BIA) based hydration status monitoring system before the competition and to compare it with a urine color chart scaling system. Design Observational descriptive study with anonymous data collection after informed consent during the Team Championship finals of the Swiss Judo Federation (SJV). Setting Field measurements on the competition day just after the official selection weight-in through BIA octopolar fluid balance electrical measurement, questionnaire data. Participants All accepting male athletes of the elite national Swiss teams. Risk factor assessment Body weight, hydration habitus and status. Main outcome measurements Extracellular/Intracellular and Total body water content status before entering the fighting mat (precompetitive hydration status). Results 35 out of 48 athletes accepted to participate. 54% were under the current accepted euhydration status, but only 14% were in the non optimal urine color group. 70% had inappropriate drinking habits. Conclusions Bioelectrical Impedance Analysis (BIA) is a quick way to determine the total water content of competitive judokas on the field without being invasive and seems to be more precise than a color chart evaluation. Clinical application: it can help the Judo community to gather better knowledge on hydration problems. We expect this system to be part of a national and an international strategy of tracking hydration questions.
Traumatic Cerebellar Hematoma Without Subdural Hematoma
Authors: Nikolas Papadakis
Journal: JAMA (1976)

TRAUMATIC cerebellar hematoma, unaccompanied by subdural or eqidural hematoma of the posterior fossa, is a rare entity.<sup>1</sup>Wright<sup>2</sup>reports six intracerebellar hematomas among 17 posterior fossa hematomas over a ten-yearn period. Even this number appears to be unusually high when compared to other series. For this reason, we are reporting a case of traumatic cerebellar hematoma and discussing the relevant diagnostic and therapeutic points. <h3>Report of a Case</h3> On Dec 12, 1973, a 64-year-old man struck his head on an overhanging pipe and fell to the ground. He was not unconscious. Subsequently, progressive confusion, disorientation, and difficulty with gait and speech occurred. Three days prior to admission, he noted severe frontal headache. His family observed changes in personality, lethargy, and irritability. Examination on Dec 18,1973, showed the patient to be a somewhat lethargic elderly man, complaining of severe headache. Pulse was 60 beats per
Abstract 1769: Real-time imaging demonstrates cancer cells exposed to UV irradiation either repair their DNA or die.
Authors: Shinji Miwa, Shuya Yano, Yukihiko Hiroshima, Yasunori Tome, Fuminori Uehara, Sumiyuki Mii, Hiroaki Kimura, Katsuro Hayashi, Hiroyuki Tsuchiya, Elena Efimova, Michelle Digman, Enrico Gratton, Robert M. Hoffman
Journal: Cancer Research (2013)

Abstract The DNA repair protein 53BP1 is re-localized in foci after DNA damage. In this study, we imaged the real-time response of 53BP1 linked to GFP to DNA damage induced by UV irradiation. Inhibition of proliferation by UV irradiation was analyzed by a clonogenic assay. The relocalization of GFP fused to the chromatin-binding domain of 53BP1 was imaged after UV irradiation of MiaPaca-2 53BP1-GFP human pancreatic cancer cells. The clonogenic assay demonstrated that UVC dose-dependently inhibited cell proliferation, while UVA and UVB showed little effect. During live-cell imaging, 53BP1-GFP foci formation was observed within 30 min after UVC irradiation. High-dose UVC also induced apoptosis within 24 h after irradiation. The cells treated with UVC irradiation appear to have two different fates: DNA repair or apoptosis. A fraction of the cells underwent apoptosis, and the other fraction repaired their DNA as evidenced by 53BP1 focus formation. The present study demonstrates that some cells may repair their DNA successfully and others can not. This has important implication for UV-based photodynamic therapy. Citation Format: Shinji Miwa, Shuya Yano, Yukihiko Hiroshima, Yasunori Tome, Fuminori Uehara, Sumiyuki Mii, Hiroaki Kimura, Katsuro Hayashi, Hiroyuki Tsuchiya, Elena Efimova, Michelle Digman, Enrico Gratton, Robert M. Hoffman. Real-time imaging demonstrates cancer cells exposed to UV irradiation either repair their DNA or die. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1769. doi:10.1158/1538-7445.AM2013-1769
Cerumen Removal Guidelines Wax Practical
Authors: Mike Mitka
Journal: JAMA (2008)

The American Academy of Otolaryngology-Head and Neck Surgery Foundation has issued the first comprehensive clinical guidelines for assessment, management, and treatment of impacted cerumen, or earwax (Roland PS et al. Otolaryngol Head Neck Surg. 2008;139[3]:S1-S21).
Higher Plasma Levels of Advanced Glycation End Products Are Associated With Incident Cardiovascular Disease and All-Cause Mortality in Type 1 Diabetes
Authors: Johanna W. Nin, Anders Jorsal, Isabel Ferreira, Casper G. Schalkwijk, Martin H. Prins, Hans-Henrik Parving, Lise Tarnow, Peter Rossing, Coen D. Stehouwer
Journal: Diabetes Care (2011)

OBJECTIVE To investigate the associations of plasma levels of advanced glycation end products (AGEs) with incident cardiovascular disease (CVD) and all-cause mortality in type 1 diabetes and the extent to which any such associations could be explained by endothelial and renal dysfunction, low-grade inflammation, and arterial stiffness. RESEARCH DESIGN AND METHODS We prospectively followed 169 individuals with diabetic nephropathy and 170 individuals with persistent normoalbuminuria who were free of CVD at study entry and in whom levels of Nε-(carboxymethyl)lysine, Nε-(carboxyethyl)lysine, pentosidine and other biomarkers were measured at baseline. The median follow-up duration was 12.3 (interquartile range 7.6–12.5) years. RESULTS During the course of follow-up, 82 individuals (24.2%) died; 85 (25.1%) suffered a fatal (n = 48) and/or nonfatal (n = 53) CVD event. The incidence of fatal and nonfatal CVD and of all-cause mortality increased with higher baseline levels of AGEs independently of traditional CVD risk factors: hazard ratio (HR) = 1.30 (95% CI = 1.03–1.66) and HR = 1.27 (1.00–1.62), respectively. These associations were not attenuated after further adjustments for markers of renal or endothelial dysfunction, low-grade inflammation, or arterial stiffness. CONCLUSIONS Higher levels of AGEs are associated with incident fatal and nonfatal CVD as well as all-cause mortality in individuals with type 1 diabetes, independently of other risk factors and of several potential AGEs-related pathophysiological mechanisms. Thus, AGEs may explain, in part, the increased cardiovascular disease and mortality attributable to type 1 diabetes and constitute a specific target for treatment in these patients.
Functional differences between rat islets of ventral and dorsal pancreatic origin.
Authors: E R Trimble, P A Halban, C B Wollheim, A E Renold
Journal: Journal of Clinical Investigation (1982)

Do functional linkages between islet endocrine cells exist? The effect of differences in frequency and distribution of islet endocrine cells on B cell function was examined in islets from the ventral (ventral islets) and dorsal (dorsal islets) areas of the rat pancreas. Dorsal islets contained 10 times as much glucagon as ventral islets, whereas insulin and total protein contents were similar. Basal rates of insulin secretion and proinsulin biosynthesis were similar in the two types of islet, but, under conditions of glucose stimulation, both insulin secretion and proinsulin biosynthesis were significantly greater in the glucagon-rich dorsal islets. Similarly, glucose utilization rates an ATP levels were greater in dorsal islets. In contrast, the rates of processing of newly synthesized proinsulin were similar in ventral and dorsal islets. That the islet glucagon content may have affected B cell function is inferred from two independent findings. Firstly, basal and glucose-stimulated cyclic AMP contents of glucagon-rich dorsal islets were greater than those of ventral islets. Secondly, in the presence of excess exogenous glucagon (1 microgram/ml), the differences in glucose-induced insulin secretion and proinsulin biosynthesis rates between the two types of islets were eliminated. These results strongly suggest that changes in the relative proportions of the different islet endocrine cells exert marked effects on islet function. In particular, a greater A cell and glucagon content is associated with higher rates of glucose-induced insulin secretion and biosynthesis.
Improved Management of Acute Embolism and Thrombosis With an Embolectomy Catheter
Authors: Jameson L. Chassin
Journal: JAMA (1965)

A modification of the balloon-catheter technique permits the safe extraction of emboli and thrombi through remote arteriotomy incisions made at sites selected because of accessibility with the patient under local anesthesia and the absence of local calcified plaques. This has been valuable in removing emboli and thrombi from the aorta and the popliteal, axillary, superior mesenteric, and internal carotid arteries. Because of the efficacy of the catheter in removing a propagated thrombus, successful embolectomy and thrombectomy has been accomplished even after a delay of 3 to 21 days. With this improvement in technique, surgery should be considered the preferred form of therapy for acute popliteal and axillarybrachial arterial occlusions.
Acute Charcot’s Arthropathy Despite 11 Years of Normoglycemia After Successful Kidney and Pancreas Transplantation
Authors: Rossana Caldara, Crispino Grispigni, Ennio La Rocca, Paola Maffi, Elena Orsenigo, Carlo Socci, Gianfranco Fraschini, Valerio Di Carlo, Guido Pozza, Antonio Secchi
Journal: Diabetes Care (2001)

Charcot’s arthropathy is one of the most debilitating orthopedic sequelae of diabetes. Regarding its pathogenesis, the current theory suggests a role of diabetic peripheral and autonomic neuropathy (1).

Kidney-pancreas transplantation is an accepted therapeutic approach in uremic type 1 diabetic patients, providing normalization of glycometabolic control and improvement of secondary diabetic complications, including neuropathy (2,3,4).

We report a case of a diabetic uremic patient who developed acute Charcot’s arthropathy despite 11 years of tight metabolic control after successful kidney and pancreas transplantation. A 41-year-old type 1 diabetic uremic male patient underwent kidney and pancreas transplantation. His immunosuppression …
Diabetes in Asian Immigrant Populations
Authors: Swapnil Rajpathak, Judith Wylie-Rosett, Michael Alderman
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
KLF5 inhibits angiogenesis in PTEN-deficient prostate cancer by attenuating AKT activation and subsequent HIF1α accumulation
Authors: Xinpei Ci, Changsheng Xing, Baotong Zhang, Zhiqian Zhang, Jenny Jianping Ni, Wei Zhou, Jin-Tang Dong
Journal: Molecular Cancer (2015)

KLF5 is a basic transcriptional factor that regulates multiple physiopathological processes. Our recent study showed that deletion of Klf5 in mouse prostate promotes tumorigenesis initiated by the deletion of Pten. While molecular characterization of Klf5-null tumors suggested that angiogenesis was partially responsible for tumor promotion, the precise function and mechanism of KLF5 deletion in prostate tumor angiogenesis remain unclear.Applying histological staining to Pten-null mouse prostates, we observed that deletion of Klf5 significantly increased the number of microvessels, accompanied by the upregulation of multiple angiogenesis-related genes based on microarray analysis with MetaCore software. In human umbilical vein endothelial cells (HuVECs), tube formation and migration, both of which are indicators of angiogenic activities, were decreased by conditioned media from PC-3 and DU 145 human prostate cancer cells with KLF5 overexpression, but increased by media from cells with KLF5 knockdown. HIF1α, a key angiogenesis inducer, was upregulated by KLF5 loss at the protein but not the mRNA level in both mouse tissues and human cell lines, as determined by immunohistochemical staining, real-time RT-PCR and Western blotting. Consistently, KLF5 loss also upregulated VEGF and PDGF, two pro-angiogenic mediators of HIF1α function, as analyzed by immunohistochemical staining in mouse tissues and ELISA in conditioned media. Mechanistically, AKT activity, which caused the accumulation of HIF1α, was increased by KLF5 knockout or knockdown but decreased by KLF5 overexpression. PI3K/AKT inhibitors consistently abolished the effects of KLF5 knockdown on angiogenic activity, HIF1α accumulation, and VEGF and PDGF expression.KLF5 loss enhances tumor angiogenesis by attenuating PI3K/AKT signaling and subsequent accumulation of HIF1α in PTEN deficient prostate tumors.
TRANSESOPHAGEAL ECHOCARDIOGRAPHIC CHARACTERIZATION OF MITRAL VALVE PATHOLOGY IN SUBJECTS WITH DEGENERATIVE MITRAL REGURGITATION UNDERGOING PERCUTANEOUS REPAIR WITH THE MITRACLIP DEVICE
Authors: Ehrin J. Armstrong, Christo H. Swan, Deepa Upadhyaya, Ravi Garg, Jason H. Rogers, Ted Feldman, Elyse Foster
Journal: Journal of the American College of Cardiology (2011)
DEVIATIONS OF THE NASAL SEPTUM.A REVIEW OF ONE HUNDRED OPERATIONS FOR CORRECTION.
Authors: JOSEPH S. GIBB
Journal: JAMA (1904)

The 100 cases which form the basis for the observations on septal deviations have been selected from the case books of both hospital and private work. Each case was one of more or less marked deviation. Care has been taken not to include in this list mere cartilaginous or osseous spurs, so that those cases tabulated under the head of "Spurs" represent cases in which these outgrowths were removed because it was thought that the physiologic function of the nasal chambers could be restored without recourse to the more formidable operative procedures. In tabulating the result of the operations, a good result is noted when the object sought has been attained and does not mean that in each case recorded as "good" a perfectly straight septum has been secured, nor that each case has been entirely uneventful in its course. Cases classified as "fair" were those which could not be
The Sloan-Kettering affair: could it have happened anywhere?
Authors: G. McBride
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Smoking Cessation and Risk of Stroke in Women
Authors: W. T. Longstreth, Lorene M. Nelson
Journal: JAMA (1993)

<h3>To the Editor.</h3> —In agreement with Kawachi et al,<sup>1</sup>we found cigarette smoking increased the risk of subarachnoid hemorrhage in a population-based, case-control study.<sup>2</sup>Considering the 149 male and female cases and the 298 age- and gender-matched controls, the odds ratio (OR) for current heavy smokers (&gt;20 cigarettes/day) was 11.1 (95% confidence interval [CI], 5.0 to 24.9); for current light smokers (&lt;20 cigarettes/day) the OR was 4.1 (95% CI, 2.3 to 7.3); and for former smokers the OR was 1.8 (95% CI, 1.0 to 3.2). The risk was greatest in the 3 hours following smoking a cigarette (OR, 7.0; 95% CI, 3.7 to 13.1) and then decreased, not reaching the risk in those who had never smoked until more than 10 years had passed since the last cigarette. The finding that the risk is greatest in the 3 hours after smoking suggests that a transient factor, such as
Occupational asthma caused by exposure to cyanoacrylate
Authors: S. Quirce, M. L. Baeza, P. Tornero, A. Blasco, R. Barranco, J. Sastre
Journal: Allergy (2001)

Background: Exposure to acrylates may give rise to rhinitis and asthma in both industrial and domestic environments. The mechanisms underlying these respiratory conditions caused by acrylates remain largely unknown. Methods: We studied two assembly operators exposed to cyanoacrylate glue who developed rhinitis and asthma symptoms. The causal relationship of these symptoms to cyanoacrylate glue exposure was investigated by serial peak expiratory flow (PEF) monitoring at work and off work. Moreover, inhalation testing was performed by asking the patients to mimic exposure at work with the cyanoacrylate glue in a 7‐m 3 challenge chamber. Results: Serial PEF monitoring at work and away from work was consistent with occupational asthma in both patients. The methacholine inhalation test was negative in patient 1 (off work) and showed bronchial hyperresponsiveness in patient 2. After 20‐min exposure to cyanoacrylate, the patients had late and progressive asthmatic reactions, respectively, and the methacholine test became positive in patient 1. Induced‐sputum samples obtained 3 and 24 h after the cyanoacrylate challenge showed a marked increase in sputum eosinophils. Conclusions: Exposure to cyanoacrylate in these patients provoked not only variable airflow limitation and bronchial hyperresponsiveness, but also pronounced eosinophilia in sputum.
Re: Claus G. Roehrborn, Steven A. Kaplan, J. Stephen Jones, Joseph T. Wang, Tamara Bavendam, Zhonghong Guan. Tolterodine Extended Release With or Without Tamsulosin in Men With Lower Urinary Tract Symptoms Including Overactive Bladder Symptoms: Effects of Prostate Size. Eur Urol 2009;55:472–81
Authors: Shiu-Dong Chung, Bin Chiu, Yao-Chi Chuang, Hann-Chorng Kuo
Journal: European Urology (2008)
IS THE USE OF DRUG-ELUTING STENTS RELATED TO THE RISK OF TARGET VESSEL REVASCULARIZATION
Authors: David J. Malenka, Harold Dauerman, Alan Wiseman, Richard Boss, David Goldberg, William Phillips, Thomas Ryan, Mirle Kellett, Matthew Watkins, John Robb, John Jayne, Patrick Magnus, David Zlotnick, Chad Bohn
Journal: Journal of the American College of Cardiology (2013)
Abnormal Gallium Scan in Regional Enteritis
Authors: KWANG G. JOO, RALPH LANDSBERG, K L PARTHASARTHY, SURAJ P. BAKSHI
Journal: Clinical Nuclear Medicine (1978)

Regional enteritis in a 41-year-old woman was localized on a 67Ga-citrate scan, appearing as a wellcircumscribed abnormality in the pelvis simulating an abscess or a malignant neoplasm. Gallium-67-citrate scintigraphy is useful in localizing granulomatous inflammations including regional enteritis, and its use may be beneficial in evaluating the extent and the state of disease process.
Dispatcher-Assisted Cardiopulmonary Resuscitation
Authors: Lindsay White, Joseph Rogers, Megan Bloomingdale, Carol Fahrenbruch, Linda Culley, Cleo Subido, Mickey Eisenberg, Thomas Rea
Journal: Circulation (2009)

Dispatcher-assisted cardiopulmonary resuscitation (CPR) instructions can increase bystander CPR and thereby increase the rate of survival from cardiac arrest. The risk of bystander CPR for patients not in arrest is uncertain and has implications for how assertive dispatch is in instructing CPR. We determined the frequency of dispatcher-assisted CPR for patients not in arrest and the frequency and severity of injury related to chest compressions.The investigation was a prospective cohort study of adult patients not in cardiac arrest for whom dispatchers provided CPR instructions in King County, Washington, between June 1, 2004, and January 31, 2007. The study focused on those who received chest compressions. Information was collected through review of the audio and written dispatch report, written emergency medical services report, hospital record, and telephone survey. Of the 1700 patients for whom dispatcher CPR instructions were initiated, 55% (938 of 1700) were in arrest, 45% (762 of 1700) were not in arrest, and 18% (313 of 1700) were not in arrest and received bystander chest compressions. Of the 247 not in arrest who received chest compressions and had complete outcome ascertainment, 12% (29 of 247) experienced discomfort, and 2% (6 of 247) sustained injuries likely or possibly caused by bystander CPR. Only 2% (5 of 247) suffered a fracture, and no patients suffered visceral organ injury.In this prospective study, the frequency of serious injury related to dispatcher-assisted bystander CPR among nonarrest patients was low. When coupled with the established benefits of bystander CPR among those with arrest, these results support an assertive program of dispatcher-assisted CPR.