tbuckley/cabot-search huggingface dataset:
Death in Hollywood
Authors: G. D. Smith
Journal: BMJ (2001)

Appearances are deceptive p 1491 

Death in Hollywood—the subject of a paper in this issue (p 1491)1—brings to mind the page turning pleasures of Kenneth Anger's classic tales of a contemporary Babylon. 2 3 The mixture of drugs, drink, sex, violence, monstrous egos, gangsterism, speed, and madness is often most starkly revealed in the premature deaths of (sometimes has-been) stars. The suicides can be particularly indicative of the roller coaster nature of fame: Albert Dekker wrote sections of the poor reviews from his last film in crimson lipstick on his body before hanging himself; Lou Tellegen stabbed himself with gold scissors engraved with his name, surrounded by film posters, photographs, and newspaper cuttings from his days of triumph; and Peg Enwistle jumped to her death from one of the giant letters of the Hollywood sign (setting off a spate of copycat leaps into oblivion). Among the better known suicides are (probably) Marilyn Monroe and her Oscar-winning co-star in All About Eve , George Sanders, whose note read “Dear World: I am leaving you because I am bored. I am leaving you with your worries in this sweet cesspool.”

To these suicides can be added the long list of those for whom the road to excess led to premature demise. Among the stars of the silent screen were Wally Reid (morphine), John Gilbert (drink), Alma Rubens (heroin), Olive …
Diagnosis and management of varicose veins in the legs: summary of NICE guidance
Authors: G. Marsden, M. Perry, K. Kelley, A. H. Davies
Journal: BMJ (2013)

Varicose veins in the lower limbs are a common problem, estimated to affect at least a third of the UK population.1 Although some individuals with varicose veins remain asymptomatic, others may experience pain, aching, heaviness, and itching, that can impair quality of life.2 3 About 10% of people with varicose veins go on to develop skin changes, such as pigmentation or eczema,4 while about 3% may develop venous ulcers.5 At present there is substantial variation across the UK as to who qualifies for referral or treatment, and how varicose veins are treated.6 Clear guidance on which individuals should be referred to specialist vascular services, as well as the most clinically effective and cost effective treatment, is required. This article summarises the most recent recommendations from the National Institute for Health and Care Excellence (NICE).7 NICE recommendations are based on systematic reviews of best available evidence and explicit consideration of cost effectiveness. When minimal evidence is available, recommendations are based on the Guideline Development Group’s experience and opinion of what constitutes good practice. Evidence levels for the recommendations are given in italic in square brackets. ### Referral to a vascular service Refer people to a vascular service if they have any of the following:
CARDIAC RESYNCHRONIZATION THERAPY IS LESS EFFECTIVE IN THE PATIENTS WITH CARDIAC SARCOIDOSIS: INSIGHTS FROM CUBIC STUDY
Authors: Seiko Nakajima, Koji Hanazawa, Kazuaki Kaitani, Chisato Izumi, Yoshihisa Nakagawa, Kenji Ando, Takeshi Arita, Satoki Fujii, Koichi Inoue, Natsuhiko Ehara, Satoshi Shizuta, Masakiyo Nobuyoshi, Takeshi Kimura, Takaaki Isshiki
Journal: Journal of the American College of Cardiology (2013)
The Ipswich Touch Test at home had 78% sensitivity and 94% specificity for detecting loss of foot sensation
Authors: Aonghus O'Loughlin, Sean F. Dinneen
Journal: Annals of Internal Medicine (2015)

Source Citation Sharma S, Kerry C, Atkins H, Rayman G. The Ipswich Touch Test: a simple and novel method to screen patients with diabetes at home for increased risk of foot ulceration. Diabet Med. 2014;31:1100-3. 24673517
Maternal immune response to helminth infection during pregnancy determines offspring susceptibility to allergic airway inflammation
Authors: Kathrin Straubinger, Sabine Paul, Olivia Prazeres da Costa, Manuel Ritter, Thorsten Buch, Dirk H. Busch, Laura E. Layland, Clarissa U. Prazeres da Costa
Journal: Journal of Allergy and Clinical Immunology (2014)
A REAL-TIME THREE-DIMENSIONAL ECHOCARDIOGRAPHIC QUANTITATIVE ANALYSIS OF LEFT ATRIAL FUNCTION IN ASYMPTOMATIC PATIENTS WITH B-THALASSEMIA MAJOR WITHOUT MYOCARDIAL IRON OVERLOAD
Authors: Ioannis Felekos, Constantina Aggeli, Konstantina Kosma, Stauroula Lagoudakou, Polychronis Stergiou, George Roussakis, Christina Kazazaki, Christos Pitsavos, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2011)
USE OF A RETAINED OR INLYING DUODENAL TUBE IN TREATMENT OF GASTRO-INTESTINAL COMPLICATIONS IN RENAL DISEASE
Authors: Hugh H. Young
Journal: JAMA (1930)

This case, which demonstrates the great value of a duodenal tube retained for a long time in a patient with severe uremia, accompanied by nausea and vomiting, is, I believe, worthy of being reported: <h3>REPORT OF CASE</h3><h3>History.</h3> —H. V., a man, aged 69, was admitted to the Brady Urological Institute, Johns Hopkins Hospital, Nov. 2, 1929. The following history was given by his physician, Dr. Ramon deLara of Santo Domingo: The family and past histories had been negative, except that the patient had had slight symptomless hematuria for five years. The blood was discovered only on microscopic examination, and there were no symptoms referable to the urinary tract. He had never had any renal colic or passed a calculus, and had not suffered from pain in the back or loins or from any radiating pains. The general health had always been good. Oct. 18, 1929, while mounting a horse,
Abstract 4914: AKT- and ERK signaling inhibition does not sensitize GBM cells to chemo-/radiation <i>in vitro</i>
Authors: Ravi Narayan, Rogier Dik, Jaap van den Berg, Lukas J.A. Stalpers, Brigitta G. Baumert, Ben J. Slotman, Peter Sminia
Journal: Cancer Research (2014)

Abstract A common feature of Glioblastoma Multiforme (GBM) is an augmented RTK/RAS/PI3K pathway signaling. This pathway has been shown to be involved in DNA repair by both NHEJ and HR in various tumor types and is thought thereby to interfere with its chemo- and radioresistance. Targeting this pathway to sensitize GBM to chemo- and radiotherapy seems to be an attractive therapeutic approach. Proliferation and clonogenic survival of U251, U87 and T98 GBM cells were assessed following exposure to, BKM120 (pan class I PI3K inhibitor), RAD001 (mTORC1 inhibitor), MK-2206 (AKT inhibitor) and/or MEK162 (ERK inhibitor) alone and in combination with either irradiation or Temozolomide (TMZ). Effectivity of each compound on its target pathway was assessed by westernblot. BEZ235 (PI3K/mTOR/DNA-PK inhibitor) was used as a positive control for radiosensitization. Our data show BKM120 and MK-2206 to effectively inhibit AKT phosphorylation at 1 uM and leads to growth inhibition in all tested cell lines. However, these compounds are not toxic on clonogenic cell survival and do not sensitize the cells to TMZ or irradiation. Increasing the dose to 5 uM and 10 uM for BKM120 and MK-2206 respectively an antagonistic effect was found in the combination with TMZ and irradiation. Effectively inhibiting mTOR, the downstream effector of AKT, by 100 nM RAD001 also does not radiosensitize GBM cells. Inhibiting the parallel ERK-pathway by 1 uM MEK162, dephosphorylates ERK1/2 and leads to a slight increase in AKT phosphorylation. Inhibiting both pathways with BKM120 and MEK162 resulted in a synergistic growth inhibition of U251 cells however no radiosensitizing effect was found in a clonogenic assay. In conclusion, selective targeting of key components in the AKT- and/or ERK signaling pathway effectively inhibits proliferation of GBM cells yet does not sensitize them to either TMZ or radiotherapy, indicating that GBM does not depend on the RTK/RAS/PI3K pathway for its DNA-repair. Citation Format: Ravi Narayan, Rogier Dik, Jaap van den Berg, Lukas J.A. Stalpers, Brigitta G. Baumert, Ben J. Slotman, Peter Sminia. AKT- and ERK signaling inhibition does not sensitize GBM cells to chemo-/radiation in vitro. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4914. doi:10.1158/1538-7445.AM2014-4914
Alterations in thyroid iodine release and the peripheral metabolism of thyroxine during acute falciparum malaria in man
Authors: Leonard Wartofsky, Daniel Martin, Jerry M. Earll
Journal: Journal of Clinical Investigation (1972)

Previous studies of thyroid function during various infections have yielded conflicting results, but most have suggested an acceleration of peripheral thyroxine (T4) turnover during the acute infectious illness. In the present studies, thyroid function was examined by a method allowing simultaneous analysis of both endogenous thyroidal release and peripheral T4 disposal in normal volunteers after induction of acute falciparum malaria. Subjects received iodide-125I, followed in 5-7 days by 131I-T4 intravenously. 4 days later, infection was induced by the injection of parasitized red blood cells. Bidaily measurements of serum protein-bound 125I and protein-bound 131I, and urinary 125I and 131I, together with frequent estimates of serum 127I-T4 (Murphy-Pattee) and free T4 (FT4), were made during a control period, during acute illness, and during convalescence. Alterations in the peripheral metabolism of 131I-T4 during infection included significant decreases in the fractional disappearance rate for T4 [(k)], and in the clearance and daily disposal of T4, all of which returned to control values during convalescence. Total serum 127I-T4 increased late in the infected period to become greater during convalescence than either before or during infection, while FT4 did not increase significantly until convalescence. An analysis of serum 131I-T4/127I-T4 and 131I-T4/PB125I ratios confirmed these observations. The slope with time of ratios for urinary 125I/131I, a reflection of thyroidal iodine release, was decreased during infection, but rebounded to control values during the convalescent period. The observed increments in serum 127I-T4 concentration in the convalescent phase may reflect in part the slowing of (k), but together with the rising ratios of urine 125I/131I suggests enhanced thyroidal T4 secretion immediately after the acute illness. Thus, with malarial infection, there appears to be an initial depression followed by a rebound in rates of thyroidal iodine release. In contradistinction to other infections, fractional turnover and daily disposal of hormone is decreased in malaria, perhaps due to hepatic dysfunction and the consequent impairment in cellular deiodinative processes.
Second degree block during reciprocal atrioventricular nodal tachycardia.
Authors: H J Wellens, J C Wesdorp, D R Düren, K I Lie
Journal: Circulation (1976)

Of 67 patients with reciprocal atrioventricular (A-V) nodal tachycardia consecutively studied by programmed electrical stimulation of the heart, nine patients showed second degree block toward the ventricle and one patient toward the atrium during tachycardia. In four patients the occurrence of block was critically related to the prematurity of the test stimulus initiating the tachycardia. In three patients block developed following increase in rate of tachycardia. In two patients block could be elicited by introducing premature ventricular stimuli during tachycardia. Our observations indicate that different mechanisms may be responsible for second degree block during reciprocal supraventricular tachycardia. The finding of second degree block during reciprocal supraventricular tachycardia excludes a tachycardia with A-V conduction over the A-V node - His pathway and V-A conduction over an accessory A-V pathway.
Human Infertility
Authors: John W. Grover, Charles E. Miller
Journal: New England Journal of Medicine (1983)

Elsewhere in this issue Collins et al. eloquently call attention to a long-known but poorly understood fact of human infertility: a substantial portion of patients will conceive while under study or after cessation of treatment.1 The call these authors make for a controlled scientific approach to the study of old and new therapies is well founded.We can quibble with small points in their report—for instance, their rather casual dismissal of the influence of diagnostic tests on the occurrence of pregnancy. Thus, "post-test pregnancies" are assigned to the "treatment-independent" group. Some patients will conceive within a short time after almost . . .
Effects of dexamethasone on fetal hemoglobin synthesis in peripheral blood erythroid burst‐forming units
Authors: Martin H. Steinberg, Mary B. Coleman, Fred A. Garver, Hernan E. Grenett, Annette Pressley, Junius G. Adams
Journal: American Journal of Hematology (1981)

Abstract Colonies derived from erythroid burst‐forming units (BFU‐E) synthesize fetal hemoglobin (HbF) in amounts that far exceed in vivo levels. There is some evidence that HbF synthesis is controlled at the level of a primitive erythroid precursor cell. Dexamethasone may potentiate the development of BFU‐E. Since a means of augmenting HbF production in sickle cell anemia or severe β‐thalassemia would be of great therapeutic value, we studied the effects of dexamethasone on HbF and γ‐globin chain synthesis in BFU‐E from patients with sickle cell anemia and controls. HbF was measured by radioimmunoassay of BFU‐E lysate and γ‐chain synthesis by the incorporation of 3 H‐leucine into globin, which was then purified by gel filtration and column chromatography. Dexamethasone (10 −9 M) produced an increase in the number of BFU‐E in 16 of 19 subjects when compared with numbers of BFU‐E cultured with only erythropoietin. The individual BFU‐E were larger and contained more subcolonies. Dexamethasone did not increase HbF or γ‐chain synthesis, and there was no relationship between increased proliferation of BFU‐E and augmented HbF production. Thus, although dexamethasone augmented the development of erythroid bursts, there was no increment in HbF.
Abstract 12222: Right Ventricular Systolic Dysfunction Predicts Adverse Outcome in Dilated Cardiomyopathy
Authors: Ankur Gulati, Georgios Manolis, Andrew Jabbour, Ronak Rajani, Tevfik Ismail, Daniel Jones, Sadaf Raza, Fariba Fanaie, Ricardo Wage, Bethan Cowley, Dudley Pennell, Sanjay Prasad
Journal: Circulation (2010)

Introduction: Cardiovascular Magnetic Resonance (CMR) is the “gold-standard” technique for assessment of ventricular function. Although LV volumes and ejection fraction (EF) are powerful predictors...
Skin sold for chemical warfare research
Authors: C. Dyer
Journal: BMJ (2001)

Surplus skin from plastic surgery patients was sold to a British defence agency for chemical warfare research without patients' knowledge, an NHS hospital trust admitted last week.

Salisbury Health Care Trust apologised for selling skin from breast and abdominal operations to the Defence Evaluation and Research Agency at nearby Porton Down, without fully explaining what it would be used for. The trust …
Are Heavy Smokers Different From Light Smokers?
Authors: Joseph A. Istvan
Journal: JAMA (1989)

<h3>To the Editor.—</h3> I read with great interest the article by Killen et al<sup>1</sup>concerning differences between light and heavy smokers in terms of body weight, mood states, and symptom report. This article is an important contribution to the literature concerning psychological and sociodemographic characteristics of smokers. As the proportion of cigarette smokers in the United States declines, it would be reasonable to suspect that the majority of those who continue to smoke in the face of social disapproval and knowledge of their own health risk do so because they are physically or psychologically dependent on tobacco. Since both dependence and health risk increase with cigarette dose, study of pharmacologic and psychological factors related to maintenance of the smoking habit in heavy smokers is of particular importance. I do feel, however, that some caution should be exercised in the interpretation of the findings presented by Killen et al. Due
Cerebral mechanisms operating in the presence and absence of inflammatory pain.
Authors: A K Jones, S W Derbyshire
Journal: Annals of the Rheumatic Diseases (1996)

During episodes ofinflammatory arthritic pain, the brain has the task of integrating new information from receptors of muscle, tendon, and skin afferents with nociceptive information from the joint capsule and, possibly, periarticular bone.This integration will incorporate motivational, affective, discriminative, at- tentional, and motor responses that may result in changes of behaviour and modification of central nervous system (CNS) processing of pain.It is as yet unclear what the nature of this CNS modification may be, and suggested influences on pain related affective-motor responses or the inflammatory process itself remain largely speculative.It is likely to be some time before we begin to have a proper understanding of the complex integrated processes that operate during arthritic pain and other chronic pains.How- ever, we are now able to measure aspects of those processes in terms of measurement of behavioural and cerebral responses to pain.These measurements are providing early clues to the possible underlying CNS mechanisms and their relation to changes in affective- motivational behaviour.This paper will review the normal brain mechanisms of the conscious appreciation of pain, together with working hypotheses for how these mechanisms are altered during inflammatory and other types of clinical pain syndromes.
The serological detection of leukemia‐associated antigens in chronic leukemia: Correlation with disease status
Authors: Marilyn S. Pollack, Gwen H. Slimp, Joseph E. Sokal
Journal: American Journal of Hematology (1977)

Abstract Changes in the expression of leukemia‐associated antigens (LAA) on the peripheral blood cells of patients with chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML) were monitored over a period of several months with a battery of heterologous antisera in a complement‐dependent microcytotoxicity test system. The sera were prepared by immunization of rabbits and monkeys with human CLL, CML, or acute lymphoblastic, myeloblastic, or myelomonocytic leukemic cells, or cell extracts. Following extensive adsorption with normal human erythrocytes and leukocytes, these sera did not exhibit reactivity with peripheral blood monuclear cells, nor, in most cases, with enriched B‐lymphocyte preparations from healthy donors. Cells from CLL patients reacted mainly with adsorbed antisera raised against lymphocytic leukemic cells, but there was significant cross‐reactivity with antisera raised against myelomonocytic leukemia cells; the number and intensity of positive reactions correlated with leukemic cell counts. Cells from patients in the chronic stage of CML reacted almost exclusively with adsorbed antisera to myeloid leukemic cells. However, blastic transformation of CML was regularly accompanied and on one occasion preceded by the appearance of reactivity with antisera to lymphocytic leukemic cells. During remission, peripheral blood cells from most CML patients were LAA‐negative; positive serologic reactions were often followed by major hematologic and clinical deterioration within a few months. These observations suggest that serological monitoring of LAA may represent a useful adjunct to present methods of evaluating the course and prognosis of chronic leukemias. Serological reactions may also have some utility in the differential diagnosis of leukemia.
SYSTEMIC CONRTICOSTEROIDS AND FOLIC ACID ANATONISTS IN THE TREATMENT OF GENRALIZED PUSTULAR PSOBLASIS EVALUATION AND PROGNOSIS BASED ON THE STUDY OF 104 CASES
Authors: TERENCE A. RYAN, HARVEY BAKER
Journal: British Journal of Dermatology (1969)

Journal Article SYSTEMIC CONRTICOSTEROIDS AND FOLIC ACID ANATONISTS IN THE TREATMENT OF GENRALIZED PUSTULAR PSOBLASIS EVALUATION AND PROGNOSIS BASED ON THE STUDY OF 104 CASES Get access TERENCE A. RYAN, TERENCE A. RYAN Institude of dermatology St. John's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar HARVEY BAKER HARVEY BAKER Institude of dermatology St. John's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 2, 1 February 1969, Pages 134–145, https://doi.org/10.1111/j.1365-2133.1969.tb15995.x Published: 01 February 1969 Article history Accepted: 17 May 1968 Published: 01 February 1969
Complaints proposals for NHS welcomed
Authors: J Warden
Journal: BMJ (1994)

A new and simpler complaints procedure for the NHS produced by a review committee has been welcomed by the health professions and by patients' organisations in Britain (see also editorial on p 1315). The health secretary, Virginia Bottomley, said that she accepts the broad thrust of the report, Being Heard; she has begun a three month consultation period before introducing legislation.

The proposals would mean that all complaints would be handled under a common system, with no distinction between clinical and non-clinical complaints or between family practice and hospitals. The same procedures would apply to all parts of the health …
Cellular expression of integrin-? is of critical importance for inducing therapeutic angiogenesis by cell implantation
Authors: T LI, H ITO, M HAYASHI, A FURUTANI, M MATSUZAKI, K HAMANO
Journal: Cardiovascular Research (2004)

Using cell-based therapy to induce therapeutic angiogenesis has been the focus of much recent attention. We used freshly collected CD117-positive stem cells (CD117(+) cells) and ex vivo expanded CD117(+) cells to investigate the role of cellular expression of several adhesion molecules in this therapeutic regimen.CD117(+) cells were separated from the bone marrow mononuclear cells of C57/BL6 mice and cell expansion was done by 2 weeks of cultivation. The cellular expression of integrin-beta(1), integrin-beta(3) and VE-cadherin was analyzed by Western blot and real-time PCR. Three-dimensional culture was performed to observe the capillary-like tube formation. We also implanted cells into the ischemic limbs of mice and evaluated the survival and incorporation of these implanted cells and measured the blood flow and microvessel density of the ischemic limbs 2 weeks after treatment.The expression of integrin-beta(1) in the expanded cells decreased significantly, to about 30% of the freshly unexpanded CD117(+) cells. However, the expression of integrin-beta(3) did not change significantly and the VE-cadherin increased after ex vivo expansion of the CD117(+) cells. Antibody perturbation to integrin-beta(1) significantly inhibited the adhesion, growth and tube formation of cultured CD117(+) cells. Furthermore, the freshly unexpanded CD117(+) cells survived well and were incorporated in microvessels after implantation into the ischemic limbs of mice, resulting in a significant increase in blood flow and microvessel density. The cell survival and incorporation decreased, and the angiogenic potency was deprived by antibody perturbation to integrin-beta(1) before implantation. Conversely, these expanded cells had weak angiogenic potency because of the poor cell survival and incorporation after implantation, but the increase in integrin-beta(1) expression by subjecting them to 24-h hypoxia prestimulation increased cell survival and angiogenic potency significantly after implantation into the ischemic limbs.These data clearly show that integrin-beta(1) is a critical adhesion molecule for inducing therapeutic angiogenesis in cell-based therapy, by regulating cell survival and differentiation after implantation into ischemic tissue.