tbuckley/cabot-search huggingface dataset:
The serum level of HMGB1 (high mobility group box 1 protein) is preferentially high in drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms
Authors: H. Fujita, S. Matsukura, T. Watanabe, N. Komitsu, Y. Watanabe, Y. Takahashi, T. Kambara, Z. Ikezawa, M. Aihara
Journal: British Journal of Dermatology (2014)

Journal Article The serum level of HMGB1 (high mobility group box 1 protein) is preferentially high in drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms Get access H. Fujita, H. Fujita Department of Environmental Immuno‐Dermatology Yokohama City University Graduate School of Medicine Yokohama Japan Search for other works by this author on: Oxford Academic Google Scholar S. Matsukura, S. Matsukura Department of Dermatology Yokohama City University Medical Center Yokohama Japan Search for other works by this author on: Oxford Academic Google Scholar T. Watanabe, T. Watanabe Department of Environmental Immuno‐Dermatology Yokohama City University Graduate School of Medicine Yokohama Japan Search for other works by this author on: Oxford Academic Google Scholar N. Komitsu, N. Komitsu Department of Environmental Immuno‐Dermatology Yokohama City University Graduate School of Medicine Yokohama Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Watanabe, Y. Watanabe Department of Environmental Immuno‐Dermatology Yokohama City University Graduate School of Medicine Yokohama Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Takahashi, Y. Takahashi National Epilepsy Center Shizuoka Institute of Epilepsy and Neurological Disorders Shizuoka Japan Search for other works by this author on: Oxford Academic Google Scholar T. Kambara, T. Kambara Department of Dermatology Yokohama City University Medical Center Yokohama Japan Search for other works by this author on: Oxford Academic Google Scholar Z. Ikezawa, Z. Ikezawa Department of Dermatology International University of Health and Welfare Atami Japan Search for other works by this author on: Oxford Academic Google Scholar M. Aihara M. Aihara Department of Environmental Immuno‐Dermatology Yokohama City University Graduate School of Medicine Yokohama Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 171, Issue 6, 1 December 2014, Pages 1585–1588, https://doi.org/10.1111/bjd.13162 Published: 01 December 2014
The Supreme Court, Liberty, and Abortion
Authors: George J. Annas
Journal: New England Journal of Medicine (1992)

While the issue of abortion has fueled a great deal of personal and political debate and controversy in the US, few have actually read the Supreme Court's rulings on Roe v. Wade and Planned Parenthood of Southeastern Pennsylvania v. Casey, which are central to the debate. This essay summarizes both rulings, examines the difference between the 2, and discusses implications for medical practice. Casey is important to states, physicians, and patients. Of central import is the ruling's restriction against states to outlaw abortion before viability. Other measures are, however, included which will complicate record keeping and securing consent. Restrictions against and/or steps required by the physician practicing abortion may also spread to apply to other medical procedures. The essay considers the future of Roe v. Wade. Whether or not a Freedom of Choice Act is ultimately passed in Congress, abortion will continue to divide large segments of the American population. Anti-abortionists will continue to attempt to overthrow women's right of free choice to abortion.
Exfoliation of the Bladder
Authors: G. Buchanan
Journal: BMJ (1871)

THE BRITISH MEDICAL 7OURNAL.[Nov. 4, I871.might have been expected, and all, except one who died, were quite cured in the course of five weeks, withoub any other bad consequences than that-most of them were deeply pitted in their faces.Nearly all of them had secondary abscesses both on the trunk and the extremities; but these, after having been opened, healed in a short time without any ill results.In order to protect the sight, I used nitrate of silver, which
Frostbite of the face and ears: epidemiological study of risk factors in Finnish conscripts
Authors: E Lehmuskallio, H Lindholm, K Koskenvuo, S Sarna, O Friberg, A Viljanen
Journal: BMJ (1995)

<h3>Abstract</h3> <b>Objective:</b>To determine the incidence of and the risk factors for local cold injuries of the face and ears in peacetime military service <b>Design:</b>Prospective, controlled epidemiological study using a questionnaire <b>Setting:</b>Finnish defence forces, 1976-89 <b>Subjects:</b>913 young male conscripts with local frostbite of the head that needed medical attention and 2478 uninjured control conscripts <b>Main outcome measures:</b>Type of activity, clothing, and other risk factors at the time of cold injury. Odds ratios were used to calculate risk. Controls were handled as one group. <b>Results:</b>The mean annual incidence of frostbite was 1.8 per 1000 conscripts. Frostbite of the ear was most common (533 conscripts (58%)), followed by frostbite of the nose (197 (22%)) and of the cheeks and other regions of the face (183 (20%)). Most conscripts (803 (88%)) had mild or superficial frostbite. Risk factors included not wearing a hat with earflaps (odds ratio 18.5 for frostbite of the ear); not wearing a scarf (odds ratio 2.1 and 3.8 for frostbite of the ear and cheeks respectively); using protective ointments (odds ratio 3.3, 4.5, and 5.6 for frostbite of the cheeks, ear, and nose respectively); being extremely sensitive to cold and having hands and feet that sweat profusely (odds ratio 3.5 for frostbite of the nose); and being transported in the open or in open vehicles under windy conditions (odds ratio 2.2 for frostbite of the cheek). <b>Conclusion:</b> Wearing warm clothing, including a scarf and a hat with earflaps, helps to prevent frostbite. Each person9s sensitivity to cold may also be important. The routine use of protective ointments should not be recommended.
Experience with Three Brescia-Cimino Shunts
Authors: R. McMillan, D. B. Evans
Journal: BMJ (1968)

Bresica–Cimino shunts inserted to facilitate intermittent dialysis may markedly increase the circulatory load on the heart. Three patients in whom there was evidence of overload are described. Thorough investigation of the cardiac output should be made in patients with fistulae of this kind, which should be closed as soon as practicable after transplantation.
Prognostic implications and molecular associations of NADH dehydrogenase subunit 4 (ND4) mutations in acute myeloid leukemia
Authors: F Damm, T Bunke, F Thol, B Markus, K Wagner, G Göhring, B Schlegelberger, G Heil, C W M Reuter, K Püllmann, R F Schlenk, K Döhner, M Heuser, J Krauter, H Döhner, A Ganser, M A Morgan
Journal: Leukemia (2011)
Young women in deprived areas in Britain are less likely to have an abortion
Authors: Susan Mayor
Journal: BMJ (2004)

Women under the age of 18 who live in more deprived areas of Britain have higher rates of conception than women in wealthier areas but are less likely to opt for an abortion, a report published this week says.

The study investigated the relation between abortion and wider social factors in women aged 17 years or less. It was based on research that included national data on geographical variations in rates of conception and abortion and in-depth interviews with 103 young women.

The results showed that between 1999 and 2001 in England and Wales, 44% of conceptions among women aged 15 to …
Hemodynamic Accompaniments of Angina
Authors: KEVIN P. O'BRIEN, LAWRENCE M. HIGGS, D. LUKE GLANCY, STEPHEN E. EPSTEIN
Journal: Circulation (1969)

The hemodynamic responses of nine patients with severe coronary artery disease were studied during the precipitation of angina by both supine exercise and increasing rates of atrial pacing. Tension-time index and the first derivative of left ventricular pressure pulse (LV dp/dt) at the onset of angina were significantly higher ( P &lt;0.01) in each patient when angina was induced by exercise than when angina was provoked by atrial pacing. Heart rate, in contrast, was significantly greater ( P &lt;0.05) when angina was precipitated by atrial pacing. Left ventricular end-diastolic pressure (LVEDP) was abnormally elevated in each patient when angina occurred during supine exercise, whereas LVEDP was normal in all patients at the onset of angina provoked by atrial pacing. On the basis of these results it appears that the hemodynamic accompaniments of angina depend to a large extent on the particular circumstances leading to the development of angina. Tension-time index, LV dp/dt, and heart rate are major determinants of myocardial oxygen consumption, and the interrelationships between the determinants of myocardial oxygen consumption are complicated. Thus, changes in any one of these determinants after a therapeutic intervention must be viewed in relation to possible changes in the others.
Is cervical cytology different from any other investigation?
Authors: A E Jackson, M J Leverton, I C C Matheson, P A Patchett, G P Pogrel
Journal: BMJ (1986)

computed tomography2 but lacks the ability to provide a differential diagnosis.Recently interest has focused on radiopharmaceuticals which allow images to be made showing regional cerebral blood flow.Two agents in par- ticular have proved useful, '231 isopropylamphetamine (IMP)3 and, more recently, 99Tc hexamethyl propyleneamineoxime (HM-PAO).4These agents not only provide the ability to identify the presence of both tumours' and infarcts,6 although both appear as areas of reduced cerebral blood flow, but they also show distinctive patterns of perfusion for some types of dementia.78We have shown that, in particular, the pattern in Alzheimer's disease is ofa bilateral reduction in perfusion in the temporo- parieto-occipital regions while in multi-infarct dementia the uptake pattern varies from normal to that of gross focal defects.9Our recent work indicates that in Huntington's chorea there may be reduced perfusion in the head of the caudate nucleus.9'mTc HM-PAO, which offers several technical advantages over '23I IMP, should be available commercially in the near future, and the imaging equipment, a tomographic gammacamera, is avail- able in most hospitals.The study is simple to perform, requiring one intravenous injection of the radiopharmnaceutical and about 30 minutes' imagig tme.
ESTIMATION OF THE COAGULATION TIME OF THE BLOOD: A SIMPLIFIED METHOD
Authors: H. Trought, J. W. Riddoch
Journal: BMJ (1936)

Burguet is of more recent origin.It is said to work by " re-educating" the ear ty minimal auditory stimuli.As one exponent of the method claims that it acts by producing a local hyperaemia, and another places the lesion in the cerebral cortex and regards it as due to intestinal toxaemia, the rationale of the method is a little difficult to grasp.It is, however, significant that the patient is warned that one or two years' treatment may be needed.
Endoscopic Submucosal Dissection of Esophageal Squamous Cell Neoplasms
Authors: Mitsuhiro Fujishiro, Naohisa Yahagi, Naomi Kakushima, Shinya Kodashima, Yosuke Muraki, Satoshi Ono, Nobutake Yamamichi, Ayako Tateishi, Yasuhito Shimizu, Masashi Oka, Keiji Ogura, Takao Kawabe, Masao Ichinose, Masao Omata
Journal: Clinical Gastroenterology and Hepatology (2006)
AN ORIGINAL OSTEO-PLASTIC OPERATION FOR THE REMOVAL OF LARGE VASCULAR TUMORS GROWING IN THE VAULT OF THE PHARYNX, ANTRUM OF HIGHMORE, SPHENO-MAXILLARY AND PTERYGO-MAXILLARY FISSURES.
Authors: JOHN A. WYETH
Journal: JAMA (1895)

Mr. Charles Bull came under my notice early in December, 1894, with the following history: In December, 1892, the patient, a student, then 18 years of age, began to complain of some difficulty in breathing through the nose. In March, 1893, he began to suffer from severe pains in his head, was very nervous, could not sleep, began to lose his appetite, and had to discontinue his studies. In June of that year he was examined by a specialist, a well-known rhinologist, who discovered a growth in the naso-pharynx and pronounced it a naso-pharyngeal polypus. From June 30 to Nov. 18, 1893, treatment was discontinued, as the young man went on a sailing voyage. On November 21 he again visited the specialist. By this time the tumor had grown considerably, and by December 14 the patient was suffering intense pain in the head, complaining that it was a pressure on
ONCE MORE ON ANTITOXIN.
Authors: CARL STRUEH
Journal: JAMA (1896)

In the issue of theJournalof January 25 of the current year, there appeared a short article of mine entitled "Criticism of the Antitoxin Treatment from a Different Standpoint," in regard to which I received a very interesting letter from my friend Dr. X. at St. P., in which letter the doctor opposes in a most instructive manner some remarks which I have made in my article. As Dr. X. apparently represents the opinion of the majority of the advocates of the antitoxin treatment, I am very much indebted to him for giving me the permission to discuss the contents of his letter in theJournal. Dr. X., in short, says: 1, that the statistics we have, at the present time, command of are made from such cases which were proven to be diphtheria from a bacteriologic examination, and that these statistics in comparison with those we had under
Cutaneous manifestations of immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome
Authors: M. Halabi-Tawil, F.M. Ruemmele, S. Fraitag, F. Rieux-Laucat, B. Neven, N. Brousse, Y. De Prost, A. Fischer, O. Goulet, C. Bodemer
Journal: British Journal of Dermatology (2008)

Journal Article Cutaneous manifestations of immune dysregulation, polyendocrinopathy, enteropathy, X‐linked (IPEX) syndrome Get access M. Halabi‐Tawil, M. Halabi‐Tawil Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar F.M. Ruemmele, F.M. Ruemmele Paediatric GastroenterologyPathology Search for other works by this author on: Oxford Academic Google Scholar S. Fraitag, S. Fraitag Pathology Search for other works by this author on: Oxford Academic Google Scholar F. Rieux‐Laucat, F. Rieux‐Laucat INSERM U768, Faculté de Médecine Necker, Université René Descartes, Paris V, France Search for other works by this author on: Oxford Academic Google Scholar B. Neven, B. Neven INSERM U768, Faculté de Médecine Necker, Université René Descartes, Paris V, FrancePaediatric Immunology, APHP, Hôpital Necker–Enfants Malades, Paris, France Search for other works by this author on: Oxford Academic Google Scholar N. Brousse, N. Brousse Pathology Search for other works by this author on: Oxford Academic Google Scholar Y. De Prost, Y. De Prost Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar A. Fischer, A. Fischer INSERM U768, Faculté de Médecine Necker, Université René Descartes, Paris V, FrancePaediatric Immunology, APHP, Hôpital Necker–Enfants Malades, Paris, France Search for other works by this author on: Oxford Academic Google Scholar O. Goulet, O. Goulet Paediatric GastroenterologyPathology Search for other works by this author on: Oxford Academic Google Scholar C. Bodemer C. Bodemer Departments of Dermatology Correspondence: Christine Bodemer. E‐mail: christine.bodemer@nck.aphp.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 160, Issue 3, 1 March 2009, Pages 645–651, https://doi.org/10.1111/j.1365-2133.2008.08835.x Published: 01 March 2009
Finding mucosal tears in collagenous colitis during colonoscopic insufflation
Authors: J C Yarze
Journal: Gut (2003)

Recently, I had the opportunity to review the interesting retrospective descriptive study of Cruz-Correa et al ( Gut 2002; 51 :600). In brief, the authors described three patients who underwent colonoscopic examination for evaluation of chronic diarrhoea. During the colonoscopic examination, prominent mucosal tears in the ascending and transverse colon regions were noted. Biopsies of macroscopically normal appearing mucosa revealed changes supportive of underlying collagenous colitis. The authors attributed the mucosal tears, and their distribution, to the collagenous colitic process.

I have wondered about another possibility. Although the examinations were performed by experienced endoscopists, could these lesions have been induced by barotrauma? Along these lines, were the lacerations seen as the colonoscope was …
Abstract 5763: VCAM1 mediates aggressive bone metastasis outbreak from tumor dormancy by engaging α4β1-positive osteoclast progenitor cells
Authors: Xin Lu, Qifeng Yang, Min Yuan, Euphemia Mu, Michael Reiss, Bruce Haffty, Joan Massagué, Yibin Kang
Journal: Cancer Research (2010)

Abstract In breast cancer patients, disseminated tumor cells can maintain in dormancy at secondary organs for a long period before relapse into life-threatening metastases. However, the molecular understanding of this process is still very limited. Here, we show that Vascular Cell Adhesion Molecule-1 (VCAM1) is essential for the conversion from dormancy to macrometastasis in a xenograft mouse model of breast cancer bone metastasis. A weakly bone-metastatic subline (SCP6) of the human breast cancer cell MDA-MB-231 was found to give rise to strongly metastatic derivatives after six-month in vivo dormancy in nude mice. Whereas no additional chromosomal alterations were detected by array-CGH, the derivatives significantly upregulated a handful of genes based on microarray analysis. Five candidate genes were evaluated by silencing their expression using short-hairpin RNA in the highly metastatic derivatives and tested by in vivo bone metastasis assay. Only the loss of expression of VCAM1 dramatically reduced the metastasis ability. Ectopic overexpression of VCAM1 in dormancy-prone sublines allowed the outgrowth of bone metastasis. We successfully blocked the initiation and the progression of bone metastasis using purified monoclonal antibodies against VCAM1 or its receptor VLA4 (integrin α4β1). Biochemical analysis showed activated NF-κB pathway is essential for the upregulation of VCAM1. Bone metastases formed by VCAM1-overexpressed tumor cells harbored numerous TRAP-positive osteoclasts and their number was dramatically attenuated with VCAM1 or VLA4 antibodies. Expression analysis using cell lines and fresh murine bone marrow showed progenitor and mature osteoclasts express α4β1. Functional assays found VCAM1 promoted osteoclast differentiation by directly tethering the α4β1-positive osteoclast progenitors. Mice with VCAM1-positive bone metastases showed enriched CD11b-positive α4β1-positive monocytic progenitor cells of osteoclasts in the bone marrow compared with mice free of bone metastases. Finally, tissue microarray analysis showed VCAM1 is upregulated in breast tumor epithelial cells in a subgroup of patients and is associated with early relapse. Overall, our study (1) established a novel mouse model for bone metastasis dormancy of breast cancer; (2) demonstrated VCAM1 as the key mediator for the conversion from dormancy to overt metastasis through engaging α4β1-positive osteoclast progenitors; (3) developed monocloncal antibodies against VCAM1 or VLA4 as promising therapeutic agents for preventing and treating bone metastasis of breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5763.
Nonlinearity and load sensitivity of end-systolic pressure-volume relation of canine left ventricle in vivo.
Authors: E T van der Velde, D Burkhoff, P Steendijk, J Karsdon, K Sagawa, J Baan
Journal: Circulation (1991)

The effects of mechanical changes in loading conditions on the left ventricular end-systolic pressure-volume relation (ESPVR) were studied in nine open-chest dogs, including three dogs studied before and after beta-adrenergic blockade. Left ventricular pressure was measured with a micromanometer, and left ventricular volume was measured with a conductance catheter. ESPVRs were obtained by increasing left atrial inflow over wide volume ranges (as much as threefold) under three different conditions: control or high or low aortic impedance. High impedance was obtained by occlusion of the descending aorta, and low impedance was obtained by a shunt between the subclavian artery and the left atrium. In the unblocked animals in 21 of 28 runs, a second-order polynomial equation gave a better fit for the ESPVR than a linear relation. To quantify the effects of the changes in aortic impedance on the ESPVR, we calculated from the quadratic equation its volume intercept (V18) and its local slope (E18) at an end-systolic pressure (Pes) of 18 kPa. In the unblocked animals, a statistically significant difference was found in V18 between low impedance (21.50 +/- 6.27 ml) and high impedance (14.10 +/- 8.98 ml; p less than 0.005) and between control (19.14 +/- 9.58 ml) and high impedance (p less than 0.05). In most dogs, E18 was increased at high and decreased at low impedance, but not significantly. In the additional experiments with beta-blockade, the nonlinearity diminished somewhat, but the load dependency of the ESPVR remained present after beta-blockade because the same leftward shift of the ESPVR with high aortic impedance was found. Two other relations, namely, of dP/dtmax and of stroke work versus end-diastolic volume, were also investigated, which on the whole showed the same behavior as the ESPVR. These results indicate that the ESPVR and dP/dtmax-Ved and stroke work-end-diastolic volume relations, when studied over a wide volume range, are nonlinear and that changes in loading conditions influence indexes of contractility derived from these relations, especially the volume intercepts, in such a way that an increase in aortic impedance may be interpreted as an increase in contractility. Blocking the beta-adrenergic receptors did not influence the load dependency of the ESPVR but, in some cases, tended to decrease the nonlinearity in concordance with the relation between contractility and nonlinearity in isolated hearts.
Observations on the FACTORS DETERMINING THE DIFFERENCE BETWEEN AN EPIDEMIC OF ONE DISEASE AND THAT OF ANOTHER
Authors: M. Greenwood
Journal: BMJ (1931)

it is rather the condition of those exposed to infectiotn Observations than the nature of the infection which determines the ON 1HE difference, in the sense of our title, between one epidemic and another.He, would explain the difference between the FACTORS DETERMINING THE DIFFERENCEI influenza of i9i8-i9 and that of igi not in terms of the BETWE;EN .ANi El'IDEMiC OF ONE DISEASE katastasis, or, as we should say, specific differenices of the infecting agent, but in terms of contrasting resistances.AND TIIAT OF ANOTHER * Sydenham, on the other hand, enormously extended the BY sphere of the katastasis.He freed it from the' naive implications of such terms as hot, cold,' moist, and dry,'
NHS misses target for introducing electronic records
Authors: K. Burke
Journal: BMJ (2002)

The NHS has completely missed last month's target to introduce electronic patient records across a third of acute hospitals—much as the medical profession had predicted. Department of Health officials admitted this month that only 3% of acute hospitals had introduced level 3 electronic patient records by 31 March, compared with the target of 35% set in its 1998 information technology (IT) strategy, Information for Health.

No results have been released for the other seven targets for March set in the 1998 strategy, suggesting that they are also showing disappointing progress.

A level 3 electronic patient record for a single episode of care would cover four areas: prescribing details, tests and procedures ordered, test results, and the “integrated care pathway”—to project manage the patient's care. A department spokeswoman admitted that there have …