tbuckley/cabot-search huggingface dataset:
HLA-A, B, C and DR antigens in nickel contact sensitivity
Authors: N. MOZZANICA, L. RIZZOLO, G. VENERONI, R. DIOTTI, S. HEPEISEN, A.F. FINZI
Journal: British Journal of Dermatology (1990)

The relationship between HLA antigens (A, B, C and DR) and nickel contact sensitivity was examined in 54 patients with contact allergy, as confirmed by an unequivocal positive patch-test reaction only to nickel. A control group was 320 healthy blood donors from the same geographical area as the patients. The HLA-A, B, C and DR antigens were typed using standard serological methods. HLA typing revealed a significant increase of HLA-DRw6 antigen in the patient group (corrected P less than 0.025) and the relative risk for patients with DRw6 to develop nickel sensitivity was 3.32.
Psychological Impact of Islet Cell-Antibody Screening: Preliminary Results
Authors: Suzanne Bennett Johnson, William J Riley, Carolyn Apperson Hansen, Michael Alan Nurick
Journal: Diabetes Care (1990)

The identification of at-risk individuals before the onset of insulin-dependent diabetes mellitus with islet cell-antibody (ICA) screening programs could have significant psychological sequelae. We initiated a descriptive study of ICA+ subjects and their family members in which reactions to study participation, anxiety, and coping responses are monitored. Described here are preliminary results from 18 ICA+ youngsters, 6 ICA+ adults, and their family members. ICA+ identification resulted in clinically significant anxiety that dissipated to normal levels over time for all participants. Both ICA+ subjects and family members coped with the news in similar ways, relying primarily on problem-focused and social-support coping strategies. Few blamed themselves for their own or their loved one's ICA+ status. There was some evidence that the ICA+ participants may minimize the potential impact of their at-risk status. Compared with family members, ICA+ subjects used more avoidance coping strategies, and few believed they would ever develop diabetes. In contrast, many family members believed their loved one would ultimately develop diabetes. Although the initial findings support the resiliency of this population, the long-term effects of ICA screening remain to be seen.
Incidence and Prevalence of Diabetes in Manitoba, 1986–1991
Authors: James F Blanchard, Sora Ludwig, Andre Wajda, Heather Dean, Kristin Anderson, Ora Kendall, Noella Depew
Journal: Diabetes Care (1996)

To estimate the incidence and prevalence of diabetes among adults in Manitoba, Canada, from 1986 to 1991.A population-based database of individuals diagnosed with diabetes (Manitoba Diabetes Database) was created using data from Manitoba Health's comprehensive insurance system. Using this database, estimates of the annual incidence and prevalence of diabetes among Manitoba adults aged > or = 25 years were made for the years 1986-1991. Age-specific and age-adjusted rates were calculated separately for men and women.The prevalence of diabetes in 1991 was 66.9/1,000 among adults > or = 25 years. Between 1986 and 1991 the age-adjusted prevalence rose steadily among both men and women. In 1991, the incidence of diabetes was 5.6/1,000. After an observed decline prior to 1989, the annual incidence of diabetes appears to be relatively stable.The prevalence of diabetes is increasing steadily despite relatively stable incidence rates. Population-based data are required for projecting future trends and are an important tool for planning the required health resources.
Electron microscopy of ancient Egyptian skin
Authors: PETER K. LEWIN, ERNEST CUTZ
Journal: British Journal of Dermatology (1976)

Sections of skin were examined by electron microscopy from the sole of the foot of a 14-year-old Egyptian, who died 3200 years ago and was preserved naturally by desiccation. Remarkable ultrastructural preservation of the epidermal cells and their components was found.
Efficacy of metformin in the treatment of NIDDM. Meta-analysis.
Authors: K Johansen
Journal: Diabetes Care (1999)

OBJECTIVE: The results differ concerning randomized controlled trials of the effects of metformin on blood glucose regulation and body weight. To get a systematic overview, a meta-analysis of the efficacy of metformin was performed by comparing metformin with placebo and sulfonylurea. RESEARCH DESIGN AND METHODS: All randomized controlled trials published since 1957 were selected by searching the Current List of Medical Literature, Cumulated Index Medicus, Medline, and Embase, Meta-analysis was performed calculating weighted mean difference (WMD) of fasting blood glucose, glycosylated hemoglobin, and body weight. RESULTS: Nine randomized controlled trials comparing metformin with placebo and ten comparing metformin with sulfonylurea were identified. The WMD between metformin and placebo after treatment for fasting blood glucose was -2.0 mmol/l (95% CI -2.4 to -1.7) and for glycosylated hemoglobin -0.9% (95% CI -1.1 to -0.7). Body weight WMD was not significant after treatment. Sulfonylurea and metformin lowered blood glucose and glycosylated hemoglobin equally, while there was a significant WMD of body weight (-2.9 kg [95% CI -4.4 to -1.1]) because of a 1.7-kg mean increase after sulfonylurea and a 1.2-kg mean decrease after metformin. CONCLUSIONS: Metformin lowers blood glucose and glycosylated hemoglobin significantly, compared with placebo. Metformin and sulfonylurea have an equal effect on fasting blood glucose and glycosylated hemoglobin, but the body weight is significantly lower after metformin compared with sulfonylurea treatment because of an increase in body weight after sulfonylurea treatment.
France approves bill to encourage organ donations
Authors: A. Dorozynski
Journal: BMJ (1994)

The French National Assembly has approved a bill that would allow doctors to remove organs from dead patients unless they had expressed specific opposition to organ donation. The opposition would be recorded on a national register so that doctors could find out through a computer system whether they could remove a particular organ.

Transplant specialists hope that the legislation will reverse the sharp fall in organs available for transplantation. The number of transplants grew steadily in the 1980s, reaching a peak of 3572 in 1991. Since …
Feasibility of endoscopic mucosal resection for superficial pharyngeal cancer: a minimally invasive treatment
Authors: H. Suzuki, Y. Saito, I. Oda, S. Nonaka, Y. Nakanishi
Journal: Endoscopy (2010)

See also: Commentaire de travail de H. Suzuki et al., pp. 1Endoscopy 2010; 42(01): 90-90DOI: 10.1055/s-0031-1291831
Picture Museum of Sorcery Magic &amp;amp; Alchemy.
Authors: Lester S. King
Journal: JAMA (1963)

The author, a French Catholic who devoted himself largely to scholarly studies of the occult, lived from 1874 to 1929. A few weeks before his sudden death he published the book<i>Musée des Sorcières, Mages, et Alchemistes</i>, now translated for the first time. Containing almost 400 illustrations, with descriptions and commentary woven into a smoothly reading text, this work studies the iconography of mysticism and the occult. The title enumerates the three major areas of discussion, but the terms are perhaps not too apt. The first section deals largely with the depiction of witches and demons, as well as sorcerers. The second section illustrates and describes certain doctrines which relate the microcosm and macrocosm. In this area astrology and the minor forms of divination form the principal topics. The Cabbala also receives some attention but without any systematic exposition. The final portion of the book discusses briefly the iconography of
Allogeneic Bone Marrow Transplantation in Chronic Lymphocytic Leukemia
Authors: Mauricette Michallet
Journal: Annals of Internal Medicine (1996)

Letters1 November 1996Allogeneic Bone Marrow Transplantation in Chronic Lymphocytic LeukemiaMauricette Michallet, MD, Philip A. Rowlings, MB, BS, and Ciril Rozman, MDMauricette Michallet, MDHopital Eduouard Herriot Lyon, France, Medical College of Wisconsin Milwaukee, WI 53226, University of Barcelona E-08036 Barcelona, Spain.Search for more papers by this author, Philip A. Rowlings, MB, BSHopital Eduouard Herriot Lyon, France, Medical College of Wisconsin Milwaukee, WI 53226, University of Barcelona E-08036 Barcelona, Spain.Search for more papers by this author, and Ciril Rozman, MDHopital Eduouard Herriot Lyon, France, Medical College of Wisconsin Milwaukee, WI 53226, University of Barcelona E-08036 Barcelona, Spain.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-9-199611010-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree that most persons with CLL in Rai stage 0 to 2 have a good prognosis with conventional therapies and should not have bone marrow transplantation because of its treatment-related risks. Several of our co-authors expressed their agreement with this view in previous papers [1-3]. The International Bone Marrow Transplant Registry and European Group for Blood and Marrow Transplantation require participating institutions to report all consecutive transplant recipients and their outcome; they do not prescribe who should be treated or how transplantation should be done. Indications for transplantation (and standards for informed consent) are established by each ...References1. Montserrat E, Rozman C. Chronic lymphocytic leukemia treatment. Blood Rev. 1993; 7:164-75. Google Scholar2. Montserrat E, Rozman C. Chronic lymphocytic leukemia: present status. Ann Oncol. 1995; 6:219-35. Google Scholar3. Rozman C, Montserrat E. Chronic lymphocytic leukemia. N Engl J Med. 1995; 333:1052-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: Hopital Eduouard Herriot Lyon, France, Medical College of Wisconsin Milwaukee, WI 53226, University of Barcelona E-08036 Barcelona, Spain. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByComplementary and Alternative Medicine Among Advanced Cancer Patients Enrolled on Phase I Trials: A Study of Prognosis, Quality of Life, and Preferences for Decision MakingALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR ACUTE LEUKEMIA, CHRONIC LEUKEMIA, AND MYELODYSPLASIAAccidental Overdose of Multiple Chemotherapeutic Agents 1 November 1996Volume 125, Issue 9Page: 780KeywordsBloodBlood groupsBone marrowBone marrow transplantationChronic lymphocytic leukemiaTransplantation Issue Published: 1 November 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
TUMORS OF THE EYE AND ORBIT.
Authors: H. V. WURDEMANN
Journal: JAMA (1904)

There is no more interesting and outré subject<sup>1</sup>in the category of diseases than tumors of the orbit. A large proportion of these are seen and dealt with by the physician and general surgeon, rather than by the special practitioner, as the subject is intimately connected with neoplasms in other portions of the body, and in many cases is but a complication of other serious diseases. It has been deemed well to make a somewhat different classification from that hitherto used by Bull, Buller and other writers who have considered this subject as a whole. <h3>CLASSIFICATION.</h3> To accord with the demands of modern pathology, these tumors should be considered from their place of origin as follows: 1, Intraocular, which in the third stage involve the orbit and which are here but briefly considered; 2, primary in the orbit, to which this paper mostly relates; 3, secondary to neoplasms in
HIPERAMILASEMIA ASINTOMÁTICA: ¿UN LOBO CON PIEL DE CORDERO?
Authors: K Klimova, B Merino, C González, O Nogales, J García, P Menchén
Journal: Endoscopy (2014)

Introducción: La elevaciones por debajo de tres veces lo normal de amilasa son inespecíficas. Se desconoce, frecuentemente, su causa. Ha sido un hallazgo casual al que no se le ha dado relevancia clínica.
Conservatives would scrap tick box culture for more professional choice
Authors: L. Eaton
Journal: BMJ (2009)

A Conservative UK government would do away with the current “tick box” culture of the NHS and put power back in the hands of doctors and nurses, according to the party’s health spokesperson Andrew Lansley.

In a speech on Thursday, Mr Lansley launched a scathing attack on the health secretary, Alan Johnson, for having taken his foot off the pedal of Labour’s NHS reforms. In a reference to the leadership debate within the Labour party, Mr Lansley said, “Instead of driving through key reforms in the NHS, Alan Johnson’s been eyeing up another job. And the …
ADVANTAGES TO A COMMUNITY OF A HOSPITAL FOR CONTAGIOUS DISEASES.
Authors: J. L. LEAL
Journal: JAMA (1895)

Having had occasion recently to secure some information upon the subject of contagious disease hospitals, I communicated with the authorities of a large number of cities in this country, inquiring what facilities they possessed for the care and isolation of their cases of communicable disease. These inquiries were addressed to cities of the largest size as well as to those of not more than 25,000 inhabitants. The result, considering the advanced state of sanitary science, as well as the general interest regarding the public health which is now aroused, was most astonishing. I found very few cities making any claim to proper equipment for the handling of these diseases. The majority of them possess some sort of a pest house in which a stray case of smallpox, typhus or yellow fever, or cholera could be thrust and hidden away; but do not make the slightest provision for the care of
Acute Myocardial Infarction Revealed in an Isolated Premature Ventricular Beat
Authors: KERMIT H. KATZ, MORTON S. BERK, CHAIM I. MAYMAN
Journal: Circulation (1958)

Electrocardiograms of 2 patients, suspected instances of acute myocardial infarction, offered an early diagnostic clue in that there were isolated premature ventricular beats manifesting the characteristic changes produced by infarction of the myocardium. In each instance these features were present before the remainder of the electrocardiographic record was conclusive.
Imaging flow cytometry documents incomplete resistance of human sickle F-cells to ex vivo hypoxia-induced sickling
Authors: Kleber Yotsumoto Fertrin, Eduard J. van Beers, Leigh Samsel, Laurel G. Mendelsohn, Rehan Saiyed, James S. Nichols, David A. Hepp, Christine A. Brantner, Mathew P. Daniels, J. Philip McCoy, Gregory J. Kato
Journal: Blood (2014)
Grace Trespass Lennon (née Dawson)
Authors: Tim Lennon, Ruth Baker
Journal: BMJ (2004)

Psychiatrist and pioneer of the death-and-dying movementIn her groundbreaking bestseller On Death and Dying, Elisabeth Kübler-Ross overturned how physicians treat dying patients.When the book was published in 1969, death was a taboo subject and discussing it was considered morbid.Patients died alone in hospitals; physicians ignored them; and adequate pain medication was underused.The book brought these practices to the fore-and pressed for more humane treatment of the dying.The book rocked the medical profession-and at the same time also resulted in a public outcry for compassionate care of the dying.On Death and Dying is a classic work and is still in print around the world today.Kübler-Ross's work stemmed from the realisation that in her native Switzerland, death, like birth, was considered a normal part of the life cycle.In Switzerland people died at home surrounded by family and friends-and they were comfortable until the end of their lives.In contrast in the United States and other countries that placed a premium on high tech medicine, patients lay by the wayside.It was a practice she deplored.A hallmark of Kübler-Ross's work was her emphasis on communication.She stressed that patients truly wanted to review their lives, their deterioration, and imminent death.When patients and doctors could talk openly-and without fear-a good death could be achieved.In 1967 Kübler-Ross began interviewing dying patients at the University of Chicago's Billings Hospital, where she was a psychiatrist.She hoped to learn what patients were thinking as they lay dying.From her first hand research, she derived the famous five stage framework: denial, anger, bargaining, depression, and acceptance-or, as she called it, "one common denominator" of death and dying.The model outlined how patients with terminal illness grappled with their diagnosis, and their emotions along the way, right through to acceptance of their impending death.She appealed to the medical community to use it.Collin Murray Parkes, consultant psychiatrist at St Christopher's Hospice in London, credits Kübler-Ross's five stage framework and its high visibility as a driving force in stimulating research and changing
STENT THROMBOSIS IS NOT INCREASED IN CARDIAC ARREST PATIENTS UNDERGOING THERAPEUTIC HYPOTHERMIA: AN ANALYSIS OF 15,079 PROCEDURES
Authors: Neeraj Shah, Jalaj Garg, Vratika Agarwal, Kathan Mehta, Larry Jacobs, Nainesh Patel, Ronald Freudenberger
Journal: Journal of the American College of Cardiology (2015)
Postural Augmentation of Plasma Renin Activity
Authors: Edwin L. Cohen
Journal: JAMA (1966)

We have previously reported that upright posture is a potent stimulus for increasing plasma renin activity in man.<sup>1-4</sup>Clinical application of this finding has proven to be of great value in demonstrating the suppression of renin activity which is always associated with primary aldosteronism.<sup>3,4</sup>In renovascular hypertension, levels of renin activity or of renin concentration have been measured by others,<sup>5-11</sup>but, by the methods and techniques 11 ployed,<sup>5,6 8,11</sup>it has not been possible consistently to demonstrate elevations of renin activity even in patients with functionally significant lesions of the renal artery. We have already indicated briefly<sup>12,13</sup>that, with proper attention to dietary sodium and to the influence of posture, the level of peripheral plasma renin activity can be made to be critical in the diagnosis of renovascular hypertension. The purpose of this communication is to record data which demonstrate that the normal response to
Condyloma acuminata and risk of cancer.
Authors: K Woodcock
Journal: BMJ (1991)

to the new contract, I believe that it is important to acknowledge the impact of other improvements in the provision of primary care services.The improvement in the call system in Perth could be said to be the most significant change in service provision, which perhaps "kick started" the recent rise in coverage rates.Locally in South Glamorgan, where coverage is now 82%,' the increase in provision of cervical cytology in general practice started well before the new contract, aided by an improved call-recall scheme and the provision of improved training for practice nurses.In our practice we attributed coverage of over 80% in 1987 not only to the efficiency of the call system but also to the provision of a sensitive, flexible, and timely service.'Such qualities can more readily be provided in general practice than in a traditional cytology service based in a clinic.I do, however, concur with Dr Reid and col- leagues' comments about the need to modify the payment system.In particular I would strongly support the introduction of a "more extensive and graduated system of remuneration."This should provide improved rewards to those practices with high proportions of working class, immigrant, or mobile populations, where the task of improving coverage is most challenging and demands careful, sensitive, and time consuming work by the practice team.The present payment system often fails to reward such work, which requires diligent adherence to long established principles of primary care practice.
Inhibition of analgesic-induced asthma by leukotriene receptor antagonist ONO-1078.
Authors: H Yamamoto, M Nagata, K Kuramitsu, K Tabe, H Kiuchi, Y Sakamoto, K Yamamoto, Y Dohi
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

We evaluated the effect of ONO-1078, a selective leukotriene-C4, -D4, and -E4-receptor antagonist, on bronchoconstriction intensity during inhalation challenge with dipyrone (a pyrazolone derivative) in six aspirin-sensitive asthmatics. A double-blind, randomized, crossover design was used. After ingestion of 225 mg ONO-1078 or matching placebo, subjects underwent bronchial provocation with dipyrone on two occasions, separated by 4 wk. Aerosol inhalation of dipyrone was performed increasing the concentration stepwise from 0.08 to 10% (wt/vol). FEV1 was measured every 10 min up to 30 min after inhalation of each concentration. Threshold concentrations causing a fall in FEV1 > or = 20% of baseline value were 0.4% in four subjects and 2% in the other two on the placebo day. After pretreatment with ONO-1078, threshold concentration was 10% in two subjects, and no fall in FEV1 was observed in the other four, even after inhalation of 10% dipyrone. Values of PD20 were 21.9 +/- 8.2 units (mean +/- SEM) after placebo and 311.6 +/- 40.3 units after ONO-1078, respectively, and a statistically significant difference occurred (p < 0.001). Provocation of bronchoconstriction was completely inhibited in subjects whose plasma ONO-1078 levels were more than 0.5 microgram/ml. These results support the hypothesis that sulfidopeptide leukotriene-induced bronchoconstriction is one important component in the pathophysiology of aspirin-induced asthma.
Cholecystokinin Cholecystography In Clinical Practice
Authors: M. H. Nathan
Journal: JAMA (1974)

<h3>To the Editor.—</h3> In a recent article (228:997, 1974) inThe Journal, Dunn et al stated that cholecystokinin cholecystography (CCK-GB) interpreted without a clinical history is of little or no value in the diagnosis and management of acalculous biliary tract disease. They gave three reasons: first, the incidence (approximately 14%) of abnormal gallbladder contractions in their asymptomatic controlled subjects; second, the inability of CCK-GB to help predict which patients with gallbladder-like symptoms will be cured by cholecystectomy; third, the inability of CCK-GB to help predict pathological findings. As to the first argument, their controls, who came mainly from the hospital employee population, were rewarded substantially for volunteering to have CCK-GB.<sup>1</sup>It is likely that a few not-so-asymptomatic subjects would have been attracted into the study by such compensation. In addition, the incidence of gallbladder disease is much higher in women and in anyone with American Indian blood, including Latin Americans,
Angus Ian Kinnear
Authors: D. Beer
Journal: BMJ (2003)

Former medical superintendent and general practitioner Christian Medical College Hospital, Vellore, India, and general practitioner Herne Hill, London (b Woolwich, London, 1912; q St Bartholomew's Hospital, London, 1936), died from leukaemia on 21 August 2002.

After qualifying, he worked with the great pioneer missionary Amy Carmichael in Dohnavur Hospital, southern India, for 10 years before becoming medical superintendent of the Christian Medical College Hospital in Vellore, southern India, in 1950. After his return to England, in 1961 he joined a general practice in Herne Hill, south London, from where he continued his worldwide publishing programme, most notably of the Chinese thinker Watchman Nee. He leaves a wife, Jean; two children; and four grandchildren.