tbuckley/cabot-search huggingface dataset:
Evidence That Severe Asthma Can Be Divided Pathologically into Two Inflammatory Subtypes with Distinct Physiologic and Clinical Characteristics
Authors: SALLY E. WENZEL, LAWRENCE B. SCHWARTZ, ESTHER L. LANGMACK, JANET L. HALLIDAY, JOHN B. TRUDEAU, ROBYN L. GIBBS, HONG WEI CHU
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

The mechanisms associated with the development of severe, corticosteroid (CS)-dependent asthma are poorly understood, but likely heterogenous. It was hypothesized that severe asthma could be divided pathologically into two inflammatory groups based on the presence or absence of eosinophils, and that the inflammatory subtype would be associated with distinct structural, physiologic, and clinical characteristics. Thirty-four severe, refractory CS-dependent asthmatics were evaluated with endobronchial biopsy, pulmonary function, allergy testing, and clinical history. Milder asthmatic and normal control subjects were also evaluated. Tissue cell types and subbasement membrane (SBM) thickness were evaluated immunohistochemically. Fourteen severe asthmatics [eosinophil ( − )] had nearly absent eosinophils ( < 2 SD from the normal mean). The remaining 20 severe asthmatics were categorized as eosinophil ( + ). Eosinophil ( + ) severe asthmatics had associated increases (p < 0.05) in lymphocytes (CD3 + , CD4 + , CD8 + ), mast cells, and macrophages. Neutrophils were increased in severe asthmatics and not different between the groups. The SBM was significantly thicker in eosinophil ( + ) severe asthmatics than eosinophil ( − ) severe asthmatics and correlated with eosinophil numbers (r = 0.50). Despite the absence of eosinophils and the thinner SBM, the FEV1 was marginally lower in eosinophil ( − ) asthmatics (p = 0.05) with no difference in bronchodilator response. The eosinophil ( + ) group (with a thicker SBM) had more intubations than the eosinophil ( − ) group (p = 0.0004). Interestingly, this group also had a decreased FVC/slow vital capacity (SVC). These results suggest that two distinct pathologic, physiologic, and clinical subtypes of severe asthma exist, with implications for further research and treatment.
Exercise Capacity and Left Ventricular Function—Reply
Authors: Jasmine Grewal
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
49. Evaluation of Catheter-Based Deliveries of 10um Gelatin Hydrogel Microsphere, a Novel Non-Viral Vehicle, in a Porcine Heart
Authors: Kozo Hoshino, Ryuichi Yoneyama, Yoshiaki Kawase, Alec M. DeGrand, John V. Frangioni, Yasuhiko Tabata, Takeshi Kimura, Toru Kita, Roger J. Hajjar, Motoya Hayase
Journal: Molecular Therapy (2005)

Background: Biodegradable Gelatin hydrogel microsphere (GHM) has been reported as a novel non-viral vehicle for gene or protein therapy. However, it is unknown what catheter-based strategy is effective for the GHM delivery to the heart.
Weight Change Since Age 18 Years in 30- to 55-Year-Old Whites and Blacks
Authors: Philip Khoury
Journal: JAMA (1983)

To assess associations between current weight, weight at age 18 years, and weight change from age 18 years to ages 30 to 55 years with current levels of plasma cholesterol (C), high- and low-density lipoprotein C (HDLC and LDLC), triglycerides (TG), and systolic and diastolic BP (SBP and DBP), we calculated weight change from self-reported weight at age 18 years and measured weight at ages 30 to 55 years in 308 white and 69 black subjects in a random recall group and 244 whites and 66 blacks in a hyperlipidemic recall group in the Princeton School Study. In randomrecall-group whites, mean weight gain over time was greater in men than in women; black women had greater weight gain than black men, and nearly twice the weight gain of white women. Current weight and/or weight gain from age 18 years to ages 30 to 55 years in whites were inversely associated with HDLC level and positively associated with TG level, SBP, and DBP. Similar, but less consistent and significant, trends were observed for blacks. Although weight at age 18 years had no consistent independent explanatory relationship to C, TG, HDLC, and LDLC values, random-recall-group white men who were in the lowest quartile for weight at age 18 years had current levels of C, TG, SBP, and DBP that were all lower than those observed in white men who had been in the upper quartile of weight at age 18 years. Atherogenic increments in TG levels, SBP, and DBP from age 18 years to ages 30 to 55 years are a function, in part, of weight gain during these years. (<i>JAMA</i>1983;250:3179-3187)
The sequelae of razoxane therapy
Authors: R. Cerio, R.S. Wells, D.M. MacDonald
Journal: British Journal of Dermatology (1985)

Journal Article The sequelae of razoxane therapy Get access R. Cerio, R. Cerio Department of Dermatology, Guy's Hospital, London SE1 Search for other works by this author on: Oxford Academic Google Scholar R.S. Wells, R.S. Wells Department of Dermatology, Guy's Hospital, London SE1 Search for other works by this author on: Oxford Academic Google Scholar D.M. MacDonald D.M. MacDonald Department of Dermatology, Guy's Hospital, London SE1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Page 27, https://doi.org/10.1111/j.1365-2133.1985.tb12986.x Published: 01 July 1985
Role of the Frank-Starling Mechanism In Exercise
Authors: LAWRENCE D. HORWITZ, JAMES M. ATKINS, STEPHEN J. LESHIN
Journal: Circulation Research (1972)

The mechanisms which determine the response of stroke volume to mild, moderate, and severe exercise were compared in nine dogs running on a level treadmill. The dogs ran for 3-minute periods at 3-4 mph (mild exercise), 6-8 mph (moderate exercise), and 10-14 mph (severe exercise). Heart rate increased from a standing control value of 107 ± 6 beats/min to 191 ± 10 beats/min in mild, 221 ± 8 beats/min in moderate, and 263 ± 9 beats/min in severe exercise. Stroke volume increased 14%, 19%, and 15% for mild, moderate, and severe exercise, respectively. During mild exercise, left ventricular internal diameter decreased at end-systole but was unchanged at end-diastole. During moderate and severe exercise, end-diastolic diameter increased consistently as did left ventricular end-diastolic pressure. It was concluded that, despite extremely high heart rates, stroke volume increased during exercise. The augmentation in stroke volume was due to the combined effects of an increase in contractility, caused by increased sympathetic nervous system activity, and the operation of the Frank-Starling mechanism.
Anticoagulants and Myocardial Infarction
Authors: Lee Goldman, Alvan R. Feinstein
Journal: Annals of Internal Medicine (1979)

The time and expense required for adequate-sized, randomized control trials may often tempt investigators to try to answer long-standing clinical questions by retrospective analysis of data combined from old studies. In a recent example of such "pooling," the authors concluded not only that anticoagulation is beneficial in acute myocardial infarction but also that further experimental trials would be unethical. This conclusion can be disputed because of scientific, statistical, and clinical standards that were not fulfilled in the "pooled" analysis. Scientifically, the pooling of data from different sources can be valid only if the component studies contain patients who are sufficiently similar in diagnosis, clinical severity, principal treatment, and outcome events. Mathematically, exact numbers rather than percentages should be pooled. Clinically, even when the pooling process is appropriate, recent changes in ancillary therapy may negate the applicability of the old data to current medical practice.
Physician Roles, Payment Models, and Partnerships in Primary Care
Authors: Elizabeth B. Gilbertson
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1014-93 Impaired Endothelium-Dependent Dilation of Resistance Arteries in Congestive Heart Failure (CHF)
Authors: Kiyomitsu Ikeoka, Tooru Arii, Keiko Takahashi, Suguru Kobayashi, Mitsumasa Ohyanagi, Tadaaki Iwasaki
Journal: Journal of the American College of Cardiology (1995)
'Red Alert!' Accidental Penile Necrosis
Authors: Colin Markland
Journal: JAMA (1980)

Care of incontinent male patients, usually incapacitated by spinal cord injury, senility, or stroke, is a vexing nursing problem. In recent years latex condom catheters have been used as urinary collection devices, being simple, inexpensive, and easily changed each day by the patient, relative, or nursing personnel. The report in this issue (p 1238) draws attention to a serious and probably common complication, for there is always a chance that slight compression for one or two days, hidden by the latex sheath, can be disastrous. The simplicity of these devices is appealing, but some caveats are necessary. Whenever a condom collecting device is considered, urinary obstruction must be carefully ruled out by measuring residual urine both initially and periodically thereafter. More than 1 or 2 oz of residual urine should arouse suspicion of overflow incontinence, which requires prostatic surgery or a catheterization program. Other problems, such as phimosis and balanitis,
Aspirin for everyone over 50?: Authors' reply
Authors: Peter Elwood, Gareth Morgan, Ginevra Brown, Janet Pickering
Journal: BMJ (2005)

EDITOR—The case for the wider use of aspirin in vascular prophylaxis arises from the belief that subjects should be empowered to make their own decision about protecting their own health. This will be achieved only if information on the risks and benefits of preventive measures, including low dose aspirin, is widely available.

Granted, the numerical risk-harm balance of aspirin in trials based …
Coronary Artery Occlusion
Authors: Howard Bauchner
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Combining paracetamol and ibuprofen for fever in children
Authors: E. Purssell
Journal: BMJ (2008)

Fever is common in childhood and associated with conditions such as infection. Although some infections have considerable morbidity and mortality, fever itself is rarely dangerous. Fever is unpleasant, but how much of the child’s distress is caused by fever, other symptoms such as pain, or parental anxiety is unclear.

Hay et …
Continuous wave doppler determination of right ventricular pressure: A simultaneous Doppler-catheterization study in 127 patients
Authors: Philip J. Currie, James B. Seward, Kwan-Leung Chan, Derek A. Fyfe, Donald J. Hagler, Douglas D. Mair, Guy S. Reeder, Rick A. Nishimura, A. Jamil Tajik
Journal: Journal of the American College of Cardiology (1985)
Seeing the strings
Authors: R. Coombes
Journal: BMJ (2014)

In The BMJ ’s London office hangs a puppet on a string: a bespectacled doctor. It was used on a past journal cover to illustrate key opinion leaders (www.bmj.com/content/336/7658). The inference is that doctors who are paid by drug companies to advise on marketing strategies, present at conferences, or write in medical journals are puppets, whose message is controlled by their commercial paymasters.

Our cover story this week also deals with payments to doctors ( BMJ 2014;349:g4601, doi:10.1136/bmj.g4601). As Clare Dyer explains, this is not remuneration for the day job but additional income. This extra cash can take many forms: sponsorship to attend or speak at meetings or membership of an advisory board. Some doctors may own or have shares in a company that provides medical services. We …
ORGAN WEIGHTS OF NORMAL RABBITS
Authors: Wade H. Brown, Louise Pearce, Chester M. Van Allen
Journal: The Journal of Experimental Medicine (1925)

In November, 1921, a systematic study of normal rabbits was undertaken as a part of a more general investigation dealing with the subject of the animal organism in relation to disease. The present paper on organ weights is based on results obtained from a study of 350 male rabbits killed and examined between January 1, 1922, and July 1, 1924. Methods of conducting the experiments are described and the results are summarized in the form of a table and a series of text-figures. The organs studied were the heart, liver, kidneys, spleen, thymus, testicles, brain, thyroid, parathyroids, suprarenals, hypophysis, pineal gland, and representative groups of lymph nodes. The results recorded include maximum, minimum, and average weights, the median, the mode, the standard deviation, the probable error, the coefficient of variation, and the percentage distribution of organs of different weights. No final conclusions are drawn but it is pointed out that the results obtained are comparable to those that have been reported from similar studies of organ weight in man. Attention is also directed to the tendency to the occurrence of wide variations in the weights of nearly all organs, and to an apparent difference in the degree of correlation that exists between organ weight and body weight in the case of certain organs. In this connection it is pointed out that within certain limits the weight of the brain, in particular, and of other organs to a lesser degree appears to be independent of body weight. The results recorded in this paper are regarded as representing approximate values which are affected by numerous conditions for which correction should be made. These conditions will be considered in subsequent papers.
277 GI-5005 THERAPEUTIC VACCINE PLUS PEG-IFN/RIBAVIRIN IMPROVES BIOPSY NECRO-INFLAMMATORY SCORES AND ALT NORMALIZATION AT 48 WEEKS VERSUS PEG-IFN/RIBAVIRIN IN GENOTYPE 1 CHRONIC HCV PATIENTS
Authors: J.G. McHutchison, Z.D. Goodman, G.T. Everson, I.M. Jacobson, T.D. Boyer, E.R. Schiff, W.M. Lee, R.M. Chasen, J.M. Vierling, E.J. Lawitz, M. Kugelmas, N.C. Tsai, R.J. Buynak, A.M. Sheikh, B. Armstrong, T.C. Rodell, D. Apelian
Journal: Journal of Hepatology (2010)
Major Histocompatibility Complex Class I–restricted Cross-presentation Is Biased towards High Dose Antigens and Those Released during Cellular Destruction
Authors: Christian Kurts, Jacques F.A.P. Miller, Rathan M. Subramaniam, Francis R. Carbone, William R. Heath
Journal: The Journal of Experimental Medicine (1998)

Naive T cells recirculate mainly within the secondary lymphoid compartment, but once activated they can enter peripheral tissues and perform effector functions. To activate naive T cells, foreign antigens must traffic from the site of infection to the draining lymph nodes, where they can be presented by professional antigen presenting cells. For major histocompatibility complex class I–restricted presentation to CD8+ T cells, this can occur via the cross-presentation pathway. Here, we investigated the conditions allowing antigen access to this pathway. We show that the level of antigen expressed by peripheral tissues must be relatively high to facilitate cross-presentation to naive CD8+ T cells. Below this level, peripheral antigens did not stimulate by cross-presentation and were ignored by naive CD8+ T cells, although they could sensitize tissue cells for destruction by activated cytotoxic T lymphocytes (CTLs). Interestingly, CTL-mediated tissue destruction facilitated cross-presentation of low dose antigens for activation of naive CD8+ T cells. This represents the first in vivo evidence that cellular destruction can enhance access of exogenous antigens to the cross-presentation pathway. These data indicate that the cross-presentation pathway focuses on high dose antigens and those released during tissue destruction.
Preoperative Localization of Parathyroid Carcinoma Using Tc-99m MIBI
Authors: M T KITAP??I, G TASTEKIN, M TURGUT, B CANER, A KARS, I BARISTA, C BEKDIK
Journal: Clinical Nuclear Medicine (1993)

KITAPÇI, M. T. M. D.; TASTEKIN, G. M. D.; TURGUT, M. M. D.; CANER, B. M. D.; KARS, A. M. D.; BARISTA, I. M. D.; BEKDIK, C. M. D. Author Information
Comparative Effectiveness of Multivessel Coronary Artery Bypass Graft Surgery and Multivessel Percutaneous Coronary Intervention
Authors: Mark A. Hlatky, Derek B. Boothroyd
Journal: Annals of Internal Medicine (2013)

LettersSeptember 17, 2013Comparative Effectiveness of Multivessel Coronary Artery Bypass Graft Surgery and Multivessel Percutaneous Coronary InterventionMark A. Hlatky, MD and Derek B. Boothroyd, PhDMark A. Hlatky, MDFrom Stanford University School of Medicine, Stanford, California.Search for more papers by this author and Derek B. Boothroyd, PhDFrom Stanford University School of Medicine, Stanford, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-6-201309170-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Propensity score analysis adjusts only for measured confounding factors, and we agree with Dr. Kumasawa and colleagues that unmeasured confounders can affect estimates of treatment effectiveness. However, a major focus of our study was to show heterogeneity of treatment effectiveness due to key clinical factors and how this could lead to greatly different changes in mortality. Imbalances in unmeasured factors are unlikely to explain the significant variation in treatment effectiveness that we found related to measured factors. Also of note, analyses of data from randomized trials (1), which balance both measured and unmeasured factors, show the heterogeneity of ...Reference1. Hlatky MA, Boothroyd DB, Bravata DM, Boersma E, Booth J, Brooks MM, et al. Coronary artery bypass surgery compared with percutaneous coronary interventions for multivessel disease: a collaborative analysis of individual patient data from ten randomised trials. Lancet. 2009;373:1190-7. [PMID: 19303634] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Stanford University School of Medicine, Stanford, California.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M12-1564. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoComparative Effectiveness of Multivessel Coronary Bypass Surgery and Multivessel Percutaneous Coronary Intervention Mark A. Hlatky , Derek B. Boothroyd , Laurence Baker , Dhruv S. Kazi , Matthew D. Solomon , Tara I. Chang , David Shilane , and Alan S. Go Comparative Effectiveness of Multivessel Coronary Artery Bypass Graft Surgery and Multivessel Percutaneous Coronary Intervention Junji Kumasawa , Noriaki Kurita , and Shunichi Fukuhara Metrics September 17, 2013Volume 159, Issue 6Page: 435KeywordsCoronary arteriesFactor analysisPercutaneous coronary interventionStable coronary artery diseaseSurgery ePublished: 17 September 2013 Issue Published: September 17, 2013 CopyrightCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...