tbuckley/cabot-search huggingface dataset:
Hurricane's Fury Uproots Many Cancer Center Staff And Patients
Authors: S. Jenks
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Hurricane's Fury Uproots Many Cancer Center Staff And Patients Get access Susan Jenks Susan Jenks Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 18, 16 September 1992, Pages 1390–1391, https://doi.org/10.1093/jnci/84.18.1390 Published: 16 September 1992
Histochemical and biochemical correlates of ventilatory muscle fatigue in emphysematous hamsters.
Authors: G A Farkas, C Roussos
Journal: Journal of Clinical Investigation (1984)

Histochemical and biochemical characteristics of the ventilatory muscles were evaluated in control and elastase-induced emphysematous hamsters. The emphysematous group was divided into sedentary and endurance-trained groups. Endurance training consisted of treadmill running, 1 h a day, 7 d a week. The experimental period lasted 24 wk. Histochemically, the diaphragm from the sedentary emphysematous hamsters revealed a selective fast fiber atrophy which was prevented by endurance training. Training also led to a hypertrophy of the slow, high oxidative fibers. The external intercostals from both emphysematous groups revealed an increased proportion of fast oxidative fibers at the expense of a decreased number of fast glycolytic fibers. However, the fast fibers in both emphysematous groups were significantly atrophied as compared with controls. The internal intercostals revealed no adaptive changes in either size or proportion distribution of the various fiber types. Biochemically, the diaphragm of the emphysematous animals had a significantly improved oxidative potential as measured by citrate synthase, and a reduced glycolytic capacity as indicated by phosphofructokinase activity, compared with controls. The magnitudes of the biochemical changes were similar in both emphysematous groups and were consistent for diaphragmatic samples taken from the costal and crural segments. The combined internal and external intercostals also underwent significant biochemical increases in their oxidative capacity. In addition, training of the emphysematous group led to an increased glycolytic potential of the intercostals.
Dermal mucinosis with symptomatic intraneural mucin deposition: a new entity or reaction pattern?
Authors: S.C-S. Hu, G-S. Chen, K-B. Tsai, J-C. Chung, C-C.E. Lan
Journal: British Journal of Dermatology (2008)

Journal Article Dermal mucinosis with symptomatic intraneural mucin deposition: a new entity or reaction pattern? Get access S.C‐S. Hu, S.C‐S. Hu Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Tzyou 1st Road, Kaohsiung, Taiwan Search for other works by this author on: Oxford Academic Google Scholar G‐S. Chen, G‐S. Chen Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Tzyou 1st Road, Kaohsiung, TaiwanDepartment of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan Search for other works by this author on: Oxford Academic Google Scholar K‐B. Tsai, K‐B. Tsai Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Pathology, Kaohsiung Municipal Hsiao‐Kang Hospital, Kaohsiung, Taiwan Search for other works by this author on: Oxford Academic Google Scholar J‐C. Chung, J‐C. Chung Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Tzyou 1st Road, Kaohsiung, Taiwan Search for other works by this author on: Oxford Academic Google Scholar C‐C.E. Lan C‐C.E. Lan Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Tzyou 1st Road, Kaohsiung, TaiwanDepartment of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan Correspondence: Cheng‐Che E. Lan. E‐mail: ec_lan@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 160, Issue 1, 1 January 2009, Pages 200–202, https://doi.org/10.1111/j.1365-2133.2008.08871.x Published: 01 January 2009
Tonsillectomy by Guillotine and Dissection
Authors: T. B. Jobson
Journal: BMJ (1942)

Controversy regarding the best method of enucleating tonsils is ever with us.Even now there are a great many relevant points that are not appreciated by the majority of doctors and some specialists.As one who has had to perform some 15,000 of these operations by both methods, I feel that analysis of this controversy may be of interest.
Melanomas in renal transplant recipients
Authors: L. Le Mire, K. Hollowood, D. Gray, C. Bordea, F. Wojnarowska
Journal: British Journal of Dermatology (2006)

Journal Article Melanomas in renal transplant recipients Get access L. Le Mire, L. Le Mire Oxford Radcliffe Hospital, Oxford, U.K Louise Le Mire. E‐mail: mflemire@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar K. Hollowood, K. Hollowood Oxford Radcliffe Hospital, Oxford, U.K Search for other works by this author on: Oxford Academic Google Scholar D. Gray, D. Gray Oxford Radcliffe Hospital, Oxford, U.K Search for other works by this author on: Oxford Academic Google Scholar C. Bordea, C. Bordea Oxford Radcliffe Hospital, Oxford, U.K Search for other works by this author on: Oxford Academic Google Scholar F. Wojnarowska F. Wojnarowska Oxford Radcliffe Hospital, Oxford, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 154, Issue 3, 1 March 2006, Pages 472–477, https://doi.org/10.1111/j.1365-2133.2005.07094.x Published: 01 March 2006 Article history Accepted: 25 September 2005 Published: 01 March 2006
Toxicity of vitamins: complications of a health movement.
Authors: C D Evans, J H Lacey
Journal: BMJ (1986)

ethical pronouncement than a principle which is likely to have important consequences to public health. Even those who agree with  decision must admit that it is woolly. Those less charitably inclined will suspect  GMC of obfuscation. The Children's Legal Centre has already written to  General Medical Council pointing out that  new guidance displays a dangerous misunderstanding of what  Lords decided and that the publicity which it has received will already have done damage in a very sensitive area. The Brooke Advisory Centre has issued a statement that its clinics will not inform  parents, and it follows that girls at risk
Neurilemmomas of Vagus Nerve in the Neck
Authors: Julius J. Leichtling, Gerson J. Lesnick, John H. Garlock
Journal: JAMA (1963)

NEURILEMMOMAS of the vagus nerve in the neck are so rare that each case is worthy of record. The number of cases reported is not accurately known. In the 2 most recent reports, the total number found is stated to be 11 by one investigator and 21 by the other.<sup>1,2</sup>Since these growths are usually difficult to diagnose preoperatively, any aid in calling attention to this diagnosis would be extremely helpful to the physician. In this paper, 2 additional cases are presented which demonstrate a dramatic physical sign, apparently specific, for the diagnosis of these vagal tumors. <h3>Histogenesis</h3> Prior to the turn of the century, these tumors were poorly understood and were classified under a variety of names which added to the confusion (neurofibroma, perineurial fibroblastoma, peripheral glioma, spindle cell tumor). Verocay<sup>3</sup>clarified the essential histological features but applied the unsuitable name, neurinoma. This was unfortunate because nerve
Reduced intensity conditioning allogeneic bone marrow transplantation following central nervous system (CNS) relapse of acute promyelocytic leukemia: Evidence for a graft‐versus‐leukemia effect in the CNS
Authors: M. Ostronoff, M.C. Domingues, F. Ostronoff, C. Matias, R. Florêncio, K. Matias, A.P. Souto Maior, A. Sucupira, R. Calixto, C. Tagliari
Journal: American Journal of Hematology (2006)
Hyperbolic discounting lets empathy be a motivated process
Authors: George Ainslie, John Monterosso
Journal: Behavioral and Brain Sciences (2002)

The Perception-Action Model (PAM) is a cogent theory of how organisms get information about others' experiences. However, such a stimulus-driven mechanism does not handle well the complex choices that humans face about how to respond to this information. Hyperbolic reward discounting permits a reward-driven mechanism for both how aversive empathic experiences can compete for attention and how pleasurable empathic experiences are constrained.
THE VARIOUS METHODS OF PRESERVING AND MOUNTING GROSS EYE PREPARATIONS.
Authors: CASEY A. WOOD
Journal: JAMA (1903)

Early methods of preserving the enucleated eyeball and other ocular tissues were very crude. The specimen was generally placed in a bottle of ethylic or methyl alcohol of unknown strength, which not only bleached and hardened the tissues, but rendered them useless for future microscopic sections. Shrinking of the globar walls and intraocular structures proceeded until the parts became unfit for use, either as museum preparations or for other teaching purposes. Attempts were now and then made, by the addition of glycerin and other agents to the alcohol, to retard these changes, but with little permanent success. Bichlorid solutions, Müller's fluid and other chromate preparations were found to be improvements on the alcohol mixtures, but even these were not satisfactory, requiring constant care and frequent changing of the fluid, else the tissues were not affected by stains subsequently used for microscopic sections. In any case the cornea became opaque, the iris discolored
Invasive Pneumococcal Disease
Authors: Timothy R. Peters, Katherine A. Poehling
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Further analysis of the T cell receptor gamma/delta+ peripheral lymphocyte subset. The V delta 1 gene segment is expressed with either C alpha or C delta.
Authors: C Miossec, F Faure, L Ferradini, S Roman-Roman, S Jitsukawa, S Ferrini, A Moretta, F Triebel, T Hercend
Journal: The Journal of Experimental Medicine (1990)

In the present study, we have characterized the reactivity of two mAbs that are directed at the human TCR-gamma/delta. These reagents, designated anti-A13 and anti-TiV delta 2, were found to recognize antigenic determinants encoded by the TCR V delta 1 and V delta 2 gene segments, respectively. Immunofluorescence analyses performed with the antibodies confirmed that, in the TCR-gamma/delta+ cell subpopulation, the expression of V delta 2+ delta chains is largely predominant, as compared with the V delta 1+ counterparts. However, these experiments led to an apparently discrepant finding. Indeed, the total number of cells recognized by the anti-A13 plus the anti-TiV delta 2 antibodies was often greater than that detected with anti-TCR-delta 1, a reagent specific for a constant epitope of the human delta chain. Further investigation showed that the presence of a sizeable peripheral lymphocyte subset coexpressing the BMA031 and the A13 epitopes. Because the former antibody is known to recognize an invariant antigenic determinant of the TCR-alpha/beta dimer, these results suggested that the V delta 1 gene segment may be expressed with either C delta or C alpha. This hypothesis was confirmed using T2, an IL-2-dependent BMA031+ A13+ polyclonal cell line developed from peripheral blood of a healthy adult donor. Indeed, T2 cells were found to have productively rearranged the V delta 1 gene. Together, results of Northern blot analysis and cDNA cloning indicated that V delta 1 was expressed in these cells as part of a 1.6-kb full-length message including J alpha-C alpha segments.
A new hemoglobin variant, hemoglobin Nunobiki [alpha 141 (HC3) Arg----Cys]. Notable influence of the carboxy-terminal cysteine upon various physico-chemical characteristics of hemoglobin.
Authors: S Shimasaki
Journal: Journal of Clinical Investigation (1985)

A new hemoglobin variant, hemoglobin (Hb) Nunobiki, was detected in a Japanese male with marginal erythrocytosis. The Hb Nunobiki component amounted to 13.1% of the total hemoglobin. Structural analysis of this variant established the substitution of a cysteine for an arginine at the carboxy terminus of the alpha-chain (alpha 141). The oxygen equilibrium curves of Hb Nunobiki revealed extremely high oxygen affinity with a reduced Hill coefficient n, a decreased alkaline Bohr effect, and a decreased 2,3-diphosphoglyceric acid effect. The isoelectric point of the Hb Nunobiki changed during storage, although the oxyhemoglobin state was maintained. These findings could be accounted for by the specific characteristics of a newly introduced cysteinyl residue. Cysteinyl residue at alpha 141 in Hb Nunobiki did not seem to be involved in the formation of either intermolecular or intramolecular disulfide bonds under physiologic conditions. The low proportion of Hb Nunobiki (13.1%) in the propositus was also discussed after it was verified that he exhibited four alpha-globin genes per diploid cell.
Efficient Oncogene Silencing and Metastasis Inhibition via Systemic Delivery of siRNA
Authors: Shyh-Dar Li, Sumio Chono, Leaf Huang
Journal: Molecular Therapy (2008)

The selective delivery of small interfering RNA (siRNA) to metastatic tumors remains a challenging task. We have developed a nanoparticle (NP) formulation composed of siRNA, a carrier DNA, a polycationic peptide, and cationic liposomes. The NP was obtained by a self-assembling process, followed by surface modification with a polyethylene glycol (PEG)-conjugated ligand, anisamide. The NP was PEGylated and a ligand was presented to target sigma receptor-expressing murine melanoma cells, B16F10. The lung metastasis model was established by intravenous (i.v.) injection of the B16F10 cells into C57BL/6 mice. A mixture of siRNA against MDM2, c-myc, and vascular endothelial growth factor (VEGF) co-formulated in the targeted NP caused simultaneous silencing of each of the oncogenes in the metastatic nodules. Two consecutive i.v. injections of siRNA in the targeted NP significantly reduced the lung metastasis (approximately 70-80%) at a relatively low dose (0.45 mg/kg), whereas free siRNA and the nontargeted NP showed little effect. This targeted NP formulation significantly prolonged the mean survival time of the animals by 30% as compared to the untreated controls. At the therapeutic dose, the targeted NP showed little local and systemic immunotoxicity and did not decrease the body weight or damage the major organs.
Konȳne® and Hepatitis
Authors: LAURENCE A. SHERMAN
Journal: Annals of Internal Medicine (1974)

Comments1 March 1974Konȳne® and HepatitisLAURENCE A. SHERMAN, M.D., F.A.C.P.LAURENCE A. SHERMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-3-423_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent paper by Sandler, Rath, and Ruder, "Prothrombin Complex Concentrates in Acquired Hypoprothrombinemia," (Ann Intern Med79:485-491, 1973), comments on the high risk of hepatitis with Konȳne® administration in their series, a risk which, as noted in the article, had been described by other authors. This hepatitis risk has been known for several years and raises serious questions about the appropriateness of Konȳne administration in several of the patients discussed in their paper. In Case 6, Konȳne was used to correct vitamin K deficiency in preparation for renal biopsy. Given the risk of hepatitis, most physicians...References1. SANDLERRATHWICKERHAUSER SCM: Post-Konȳne hepatitis: the ineffectiveness of screening for the hepatitis B antigen (HB Ag). Transfusion 13:221-224, 1973 CrossrefMedlineGoogle Scholar2. SANDLERRUDERRATH SEC: Hepatitis following Konȳne (abstract). Program Fourteenth Annual Meeting American Society of Hematology, San Francisco, 1971, p. 117 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Departments of Pathology and Medicine Washington University School of Medicine St. Louis, Missouri 63110 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1974Volume 80, Issue 3Page: 423-423KeywordsBiopsyHepatitisHepatitis AVitamin K Issue Published: 1 March 1974 PDF downloadLoading ...
Presentation of Dr. George Herbert Hitchings for the Passano Award
Authors: Paul Talalay
Journal: JAMA (1969)

The contributions of George Herbert Hitchings, PhD, to the welfare of mankind during the last quarter of a century have encompassed not only the development of a series of unique and most valuable therapeutic agents, but also the formulation of a set of important strategic guidelines for their rational design. Of this work it may truly be said that the process by which these discoveries were made is equal in interest and importance to the discoveries themselves. Because of the imaginative and unusual nature of these concepts, I wish to give you some measure of the man himself, and the manner in which he set about his life's work. George Hitchings was born in the town of Hoquiam, Wash. Situated in Gray's Bay at the confluence of two rivers, some 12 miles from the Pacific Ocean and in the foothills of the Olympic Mountains, the community concerned itself with lumber,
Acute Intestinal Obstruction caused by Syphilitic Ulceration in the Ileum
Authors: J. M. Elder
Journal: BMJ (1904)

9 04 aged -43, who was suffering.from pain, in the stomach and vomiting.The history extended over six years, but there was at times intermis- sion of the symptoms, but never permanent relief ;. at no time had there been.haematemesis or melaena, Condition when First Seen.-The patient was extremely emaciated, had been confined to bed for some weeks, and subsisted entirely on milk.No other food of any.kind.could be tolerated, and even with milk alone she occasionally vomited a large quantity, of fluid.The stomach ap- peared to be much dilated,.reaehingnearly to-the pubes, and peristaltic
P229 Factors affecting inhaler choice and adherence in urban Liverpool
Authors: G. Tack, E. Tjia-Leong, L. Davies, C. J. Warburton
Journal: Thorax (2011)

<h3>Introduction</h3> Salmeterol/Fluticasone propionate (SFC) in the form of a dry powder inhaler (DPI) is often used in COPD, however it is also available as a metered dose inhaler (MDI). This is unlicensed for COPD and costs considerably more. At our hospital, a high proportion of COPD patients used SFC MDI, the reasons for this were unclear. This study aimed to investigate the effects of patient preference on inhaler adherence. <h3>Methods</h3> Patients admitted to hospital with an exacerbation of COPD taking either SFC DPI or MDI were recruited. All patients completed a pre-discharge questionnaire about their inhaler usage. MDI patients were switched to DPI, following education and check of their inspiratory flow. GPs were informed that their patient was involved in a study of inhalers but not the detail of the study. All patients underwent a further questionnaire at 3 months. <h3>Results</h3> 101 patients, mean (SD) age was 69 (9) years and 50% male. On admission, 66 (65%) on MDI, 35 (35%) on DPI. 100% of MDI patients were switched to DPI. At 3 months, follow-up data were available on 81 patients. Of those patients admitted on DPI, 26/29 (92%) remained on it and were satisfied with it. In the group switched from MDI to DPI, 26/52 (50%) were again receiving MDI at 3 months. 16 patients had asked for their prescription to be changed back. 10 patients had their prescription changed without their knowledge or did not receive DPI on discharge. Regardless of the reasons for the switch, 18 patients stated they preferred MDI over DPI. Reasons why patients requested the change back to MDI included dry powder irritating the throat, dry mouth and the inhaled dose not going into the lungs. <h3>Conclusion</h3> Following a relatively simple intervention 50% of COPD patients using SFC MDI could be switched and maintained on SFC DPI. Factors relating to a return to MDI included patient related and organisational factors. A whole system approach is required to effect robust systematic change in this patient group, however approximately a third of the group switched to DPI will still request a change back to MDI.
CULTIVATION OF THE VIRUS OF GRASSERIE IN SILKWORM TISSUE CULTURES
Authors: William Trager
Journal: The Journal of Experimental Medicine (1935)

A medium has been developed in which certain cells from the gonads of female silkworms multiply and live for periods of 2 to 3 weeks. In such tissue cultures, strains of silkworm grasserie virus were maintained in successive passages up to the number of ten. The virus multiplied greatly and typical polyhedral bodies formed in the cells of infected cultures.
Response to Letter Regarding Article, “Effect of the Italian Smoking Ban on Population Rates of Acute Coronary Events”
Authors: Giulia Cesaroni, Francesco Forastiere, Nera Agabiti, Carlo A. Perucci, Pasquale Valente, Piergiorgio Zuccaro
Journal: Circulation (2008)

Smoking Ban on Population Rates of Acute Coronary Events"We thank Drs Gasparrini and Gorini for their interest in our work. 1hey suggested that we test for a nonlinear time trend in the occurrence of coronary events.We did so for the reference period (2000 to 2004) before the smoking ban.A quadratic term gives a better fit to the model than a linear term among 35-to 64-year-old individuals (likelihood ratio test probability value, 0.024) and among 65-to 74-year-old individuals (likelihood ratio test probability value, 0.005).The introduction of troponin as a diagnostic tool may be one explanation for the first increase in coronary events. 2 As Drs Gasparrini and Gorini suggested, we performed a sensitivity analysis excluding the first 2 years of the reference period (2000 and 2001).The results are very similar to those presented in our article 1 : We found a decrease in acute coronary events for those aged 35 to 64 years, with a relative risk of 0.89 (95% confidence interval, 0.85 to 0.94) in 2005 compared with 2002 to 2004, as well as for those aged 65 to 74 years, with a relative risk of 0.90 (95% confidence interval, 0.86 to 0.95) in 2005 compared with 2002 to 2004.We were not surprised by the size of the effect reported in our study, as it was plausible on the basis of a theoretical calculation we did report in the published article and of the emerging literature in the field. 3In addition, the evidence of an immediate effect of environmental tobacco exposure on the cardiovascular system is already overwhelming.