tbuckley/cabot-search huggingface dataset:
Effects of Low Sulfur Fuel and a Catalyzed Particle Trap on the Composition and Toxicity of Diesel Emissions
Authors: Jacob D. McDonald, Kevin S. Harrod, JeanClare Seagrave, Steven K. Seilkop, Joe L. Mauderly
Journal: Environmental Health Perspectives (2004)

In this study we compared a "baseline" condition of uncontrolled diesel engine exhaust (DEE) emissions generated with current (circa 2003) certification fuel to an emissions-reduction (ER) case with low sulfur fuel and a catalyzed particle trap. Lung toxicity assessments (resistance to respiratory viral infection, lung inflammation, and oxidative stress) were performed on mice (C57Bl/6) exposed by inhalation (6 hr/day for 7 days). The engine was operated identically (same engine load) in both cases, and the inhalation exposures were conducted at the same exhaust dilution rate. For baseline DEE, this dilution resulted in a particle mass (PM) concentration of approximately 200 microg/m3 PM, whereas the ER reduced the PM and almost every other measured constituent [except nitrogen oxides (NOx)] to near background levels in the exposure atmospheres. These measurements included PM, PM size distribution, PM composition (carbon, ions, elements), NOx, carbon monoxide, speciated/total volatile hydrocarbons, and several classes of semivolatile organic compounds. After exposure concluded, one group of mice was immediately sacrificed and assessed for inflammation and oxidative stress in lung homogenate. Another group of mice were intratracheally instilled with respiratory syncytial virus (RSV), and RSV lung clearance and inflammation was assessed 4 days later. Baseline DEE produced statistically significant biological effects for all measured parameters. The use of low sulfur fuel and a catalyzed trap either completely or nearly eliminated the effects.
The effect of TNFα secreted from macrophages activated by titanium particles on osteogenic activity regulated by WNT/BMP signaling in osteoprogenitor cells
Authors: Sang-Soo Lee, Ashish R. Sharma, Byung-Soo Choi, Jun-Sub Jung, Jun-Dong Chang, Seonghun Park, Eduardo A. Salvati, Edward P. Purdue, Dong-Keun Song, Ju-Suk Nam
Journal: Biomaterials (2012)
Multiple cutaneous leiomyomata and erythrocytosis with demonstration of erythropoietic activity in the cutaneous leiomyomata
Authors: P.Y. VENENCIE, A. PUISSANT, G.A. BOFFA, J. SOHIER, B. DUPERRAT
Journal: British Journal of Dermatology (1982)

Journal Article Multiple cutaneous leiomyomata and erythrocytosis with demonstration of erythropoietic activity in the cutaneous leiomyomata Get access P.Y. VENENCIE, P.Y. VENENCIE Clinique Dermatologique, Hôpital Saint Louis, 2, place du Docteur A. Fournier, 75475 Paris Cedex 10 Search for other works by this author on: Oxford Academic Google Scholar A. PUISSANT, A. PUISSANT Clinique Dermatologique, Hôpital Saint Louis, 2, place du Docteur A. Fournier, 75475 Paris Cedex 10 Search for other works by this author on: Oxford Academic Google Scholar G.A. BOFFA, G.A. BOFFA CNTS, 6, rue A. Cabanel, 75739 Paris Cedex 15 Search for other works by this author on: Oxford Academic Google Scholar J. SOHIER, J. SOHIER Clinique Dermatologique, Hôpital Saint Louis, 2, place du Docteur A. Fournier, 75475 Paris Cedex 10 Search for other works by this author on: Oxford Academic Google Scholar B. DUPERRAT B. DUPERRAT Clinique Dermatologique, Hôpital Saint Louis, 2, place du Docteur A. Fournier, 75475 Paris Cedex 10 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 107, Issue 4, 1 October 1982, Pages 483–486, https://doi.org/10.1111/j.1365-2133.1982.tb00393.x Published: 01 October 1982 Article history Accepted: 31 March 1982 Published: 01 October 1982
Splenic Accumulation of Tc-99m HMDP in a Patient With Severe Alcoholic Cirrhosis of the Liver
Authors: Etsushi Kawamura, Joji Kawabe, Takehiro Hayashi, Ai Oe, Jin Kotani, Kenji Torii, Daiki Habu, Susumu Shiomi
Journal: Clinical Nuclear Medicine (2005)

The authors report unusual splenic accumulation of Tc-99m hydroxymethylene diphosphonate (HMDP) on bone scintigraphy of a patient with alcoholic cirrhosis of the liver. Laboratory studies showed hemolytic anemia and hemochromatosis resulting from alcohol abuse, both of which are thought to be related to the diffuse splenic uptake observed. When diffuse splenic accumulation by Tc-99m HMDP is seen, the existence of alcoholic hepatopathy might be considered.
An Unusual Hernia
Authors: Robert J. Freeark
Journal: JAMA (1976)

<h3>To the Editor.—</h3> I enjoyed reading the case report on "An Unusual Hernia" (235:2813, 1976) inThe Journal. The authors suggest that the gastric perforation was secondary to the incarceration and "were surprised that the gastric perforation had occurred within the abdomen rather than within the hernial sac." I would like to suggest that, in my experience, the sequence of events is just the reverse of that postulated by the authors. I believe that peritonitis occurs first (in this case due to gastric perforation), and as a consequence of the peritoneal soiling and resulting ileus, the hernial contents are pushed further into the sac and become irreducible. It is an axiom of abdominal surgery that one should never "explain" a generalized peritonitis on the basis of an incarcerated hernia. To do so usually results in a nonproductive exploration of the hernia while recognition of the true source of difficulty (appendicitis,
Exposure to high doses of birch pollen during pregnancy, and risk of sensitization and atopic disease in the child
Authors: A. Kihlström, G. Lilja, G. Pershagen, G. Hedlin
Journal: Allergy (2003)

Background: The role of maternal allergen exposure during pregnancy in sensitization and development of atopic disease in the child remains controversial. In the spring of 1993, extremely high levels of birch pollen were recorded in Stockholm, Sweden. In 1994, the corresponding pollen levels were low. The aim of this study was to assess the influence of exposure during pregnancy to high/low doses of birch pollen on the risk of sensitization and development of atopic disease in children. In addition, a comparison was made with children exposed to birch pollen in early infancy. Methods: Three hundred and eighty‐seven children with atopic heredity, born in Stockholm in July–October 1993 or 1994 (mothers exposed during pregnancy), were investigated at age 4.5 years. The children were clinically examined and were skin prick tested (SPT) with inhalant and food allergens. IgE antibodies (RAST) against birch pollen and recombinant birch pollen allergen (rBet v 1) were analysed in serum. A comparison was made with a similar group of children exposed during the same incident, but in the first 3 months of life, in 1993. Results: The children of mothers high‐dose exposed during pregnancy in 1993 tended to be more sensitized (SPT ≥ 3 mm) to birch pollen than the children with low‐dose exposure during the corresponding period in 1994 (7.6 and 4.6%, respectively, OR: 1.7; 95% CI: 0.7–4.1). A similar but weak tendency was seen for positive RAST analyses (≥0.35 kU/l) against birch pollen and rBet v 1. Children of mothers high‐dose exposed during pregnancy were significantly less sensitized to birch pollen than the children high‐dose exposed in early infancy (17.9%, OR: 0.4; 95% CI: 0.2–0.7). There was an overall trend towards a slightly increased prevalence of bronchial asthma, allergic rhinoconjunctivitis and atopic dermatitis in the group with mothers high‐dose exposed during pregnancy, compared to those with low exposure. Conclusion: Exposure of the mother during pregnancy to high levels of birch pollen resulted in a tendency towards increased risk of sensitization to the same allergen and symptoms of atopic disease in children with atopic heredity. Furthermore, our data indicate that exposure of the mother during pregnancy to inhalant allergens is less likely to result in sensitization in the child than exposure of the child in early infancy.
Wet work - home and away…
Authors: T. Agner
Journal: British Journal of Dermatology (2013)

Journal Article Wet work – home and away… Get access T. Agner T. Agner Department of Dermatology Bispebjerg Hospital University of Copenhagen Faculty of Health Science 2400 Copenhagen Denmark Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 168, Issue 6, 1 June 2013, Pages 1153–1154, https://doi.org/10.1111/bjd.12337 Published: 01 June 2013
Diazoxide no longer marketed.
Authors: P. Sonksen, C. Lowy, V. Marks, J. Maw, R. Turner, S. Amiel, R. Bailey
Journal: BMJ (1992)

fragments on breaking in the manner described, glasses annually attests to the limited life of most covered that the manufacturers had made a Certainly the base, the thickest part, does fragment pub glasses.commercial decision to stop marketing diazoxide when a glass breaks, but this is not so with the thin Tempering will never completely eliminate tablets.When we asked how such a decision could si'de wall, which either remains intact or breaks inj'uries due to glass, but it substantially reduces be made without consultation we were informed into pieces with "razor blade" edges.the risk of breakage.As De Grave states in the that consultation, with endocrinologists had taken Interestingly, the French claim only that their conclusion of a paper cited by Grimes, "In fact, place.We have not yet been able to locate those glass is three times stronger than a normal, stress toughening has provided an opportunity for the consulted.free glass; we dispute this figure, let alone Shepherd production of high resistance tumblers, dishes,We invite other would be users of the drug and colleagues' claim that it is six times stronger.plates, bowls, casseroles, etc, of great variety of to write to the suppliers, Allen and Hanburys Breaking a used tempered glass does not present a shapes, and colours which are now normally used Limited, Stockley Park West, Uxbridge, Middle- problem to an assailant, and the same jagged by everyone."' sex UB 11 IBT, requesting that the drug once more shards characteristic of normal glassware on J P SHEPHERD be supplied as tablets.breakage are produced.
The Heartmate Risk Score Predicts Morbidity and Mortality in Unselected Left Ventricular Assist Device Recipients and Risk Stratifies INTERMACS Class 1 Patients
Authors: Luigi Adamo, Michael Nassif, Anjan Tibrewala, Eric Novak, Justin Vader, Scott C. Silvestry, Akinobu Itoh, Gregory A. Ewald, Douglas L. Mann, Shane J. LaRue
Journal: JACC Heart Failure (2015)
Comparative evaluation of skin atrophy in man induced by topical corticoids
Authors: S. JABLONSKA, M. GRONIOWSKA, J. DABROSWKI
Journal: British Journal of Dermatology (1979)

In this in‐patient study, mild skin atrophy was observed clinically in 6 out of a total of 22 patieents after fluocinolone acetonide an in one patient after flumethasone pivalate ointment applications. (P < 0·005) Investigations were discontinued prematurely on days 14 and 17 in 2 patients because they developed early atrophy due to fluocinolone acetonide applications. Histological findings indicating either moderate or marked skin atrophy were evident in 15 patients after flucinolone acetonide as against one patient after flumethasone pivalate ointment applications (P < 0·001). In comparison with the controls the mean decrease in epidermal thickness was more marked after fluocinolone acetonide applications, namely 30·5% vs 21·3% after flumethasone pivalate applications. The ultrastructural tissue changes were less marked at the sites to which flumethasone pivalate was applied. In comparison with controls, the percentages of mean decrease in diameters of collagen fibrils measured in six volunteer patients ranged from 5.1% to 27·6% after fluocinolone acetonide and from 0% to 12.3% following flumethasone pivalate ointment applications. This difference was statistically significant (range P < 0·001 to < 0·001). The experimental study has demonstrated that flumethasone pivalate displays only a mild atrophogenic effect and it is clinically and histologically significantly less atrophogenic than fluocinolone acclonide. Flumethasone pivalate can therefore be reckoned as a suitable topical corticosteroid especially for the long‐term treatment of corticoid‐responsive dermatoses.
Respiratory Symptoms in Ispaghula‐Allergic Nurses after Oral Challenge with Ispaghula Suspension
Authors: Lavania Machado, Gunnemar Stalenheim
Journal: Allergy (1984)

Ispaghula powder, which is used as a component in bulk laxatives, is known to induce allergic reactions when inhaled by occupationally exposed persons. We have tested whether nurses sensitized by inhalation could get allergic symptoms when challenged by eating ispaghula. Of six nurses tested, all developed symptoms from the airways, one of them even pronounced ones requiring treatment. In all cases the dose required to produce symptoms was below the single dose of ispaghula used as a laxative.
A Human Health Perspective on Climate Change: A Report Outlining Research Needs on the Human Health Effects of Climate Change
Authors: Christopher Portier, Kimberly Thigpen Tart, Sarah Carter, Caroline Dilworth, Anne Grambsch, Julia Gohlke, Jeremy Hess, Sandra Howard, George Luber, Jeffrey Lutz, Tanya Maslak, Meghan Radtke, Joshua Rosenthal, Teri Rowles, Paul Sandifer, Joel Scheraga, Daniel Strickman, Juli Trtanj, Pai-Yei Whung
Journal: Environmental Health Perspectives (2010)
Life and Death: The Story of a Hospital
Authors: Howard F. Cook
Journal: JAMA (1989)

At the risk of being overly dramatic, I would recommend this book as<i>must</i>reading for anyone who may someday be a hospital patient. This is a book that tells the story of hospital people—doctors, nurses, administrators, planners, barbers, bakers, and all the hundreds of other workers, in plain English and with empathy. It is not a maudlin book, but it has emotional impact of a high order. The modern hospital is an enormously complex institution with a broad range of employee job descriptions, far more than any other enterprise. How does one mold these people into an efficient, effective team of medical workers to give the best scientific care to the patients? And how does one instill and then retain in these employees the human compassion to match the medical excellence? Ina Yalof's background includes having been a medical sociologist in a metropolitan hospital for 10 years. She draws
Metabolic control of circulation. Effects of iodoacetate and fluoroacetate.
Authors: C S Liang
Journal: Journal of Clinical Investigation (1977)

The circulatory effects of selective metabolic inhibition of glycolysis and of the tricarboxylic acid cycle by iodoacetate and fluoroacetate were studied in intact chloralose-anesthetized dogs. Pulmonary arterial blood pressure and vascular resistance increased after administration of both inhibitors, but neither systemic hemodynamics nor myocardial contractility changed significantly. Coronary blood flow did not change after iodoacetate administration but increased four- to five-fold after fluoroacetate. Administration of normal saline had no effect on any of the parameters. The changes in pulmonary arterial blood pressure and coronary blood flow after fluoroacetate were not mediated via the autonomic nerves or adrenergic neurohumors because they still occurred after autonomic nervous system inhibition. Neither myocardial oxygen consumption nor left ventricular work changed. A selective increase in myocardial blood flow also occurred in conscious dogs after fluoroacetate administration; hepatic artery flow was reduced, but other organ flows did not change significantly. These results indicate that pulmonary pressor and coronary dilator effects may be produced in intact dogs by selective metabolic blockade, in the absence of reduced oxygen supply or impairment in the electron transport system. These results also suggest that the increases in pulmonary arterial blood pressure, coronary blood flow, and cardiac output that occur during hypoxia probably are related to separate metabolic events in the tissue.
Filaggrin loss-of-function variant contributes to atopic dermatitis risk in the population of Northern Germany
Authors: A. Ruether, M. Stoll, T. Schwarz, S. Schreiber, R. Fölster-Holst
Journal: British Journal of Dermatology (2006)

Journal Article Filaggrin loss‐of‐function variant contributes to atopic dermatitis risk in the population of Northern Germany Get access A. Ruether, A. Ruether Institute for Clinical Molecular Biology and Search for other works by this author on: Oxford Academic Google Scholar M. Stoll, M. Stoll Institute for Clinical Molecular Biology andLeibniz‐Institute for Arteriosclerosis Research, Münster, Germany Search for other works by this author on: Oxford Academic Google Scholar T. Schwarz, T. Schwarz Department of Dermatology, Christian‐Albrechts‐University, 24105 Kiel, Germany Search for other works by this author on: Oxford Academic Google Scholar S. Schreiber, S. Schreiber Institute for Clinical Molecular Biology and Stefan Schreiber. E‐mail: s.schreiber@mucosa.de Search for other works by this author on: Oxford Academic Google Scholar R. Fölster‐Holst R. Fölster‐Holst Department of Dermatology, Christian‐Albrechts‐University, 24105 Kiel, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 155, Issue 5, 1 November 2006, Pages 1093–1094, https://doi.org/10.1111/j.1365-2133.2006.07500.x Published: 01 November 2006
Alternation of two doses of intravenous gammaglobulin in the maintenance treatment of patients with immune thrombocytopenic purpura: More is not always better
Authors: James B. Bussel, Julie Fitzgerald‐Pedersen, Charles Feldman
Journal: American Journal of Hematology (1990)

Abstract Intravenous infusion of gammaglobulin (IVGG) has been shown to be effective in the maintenance treatment of children and adults with immune thrombocytopenic purpura (ITP). The objective of this treatment is not to increase the platelet count into the normal range but rather to keep the platelet count above a safe level, usually 20,000—30,000/μI. This use requires periodic infusion whenever the platelet count falls. The dose of gammaglobulin in previous studies was 1 gm/kg/Infusion in the majority of patients. This study compared doses of 0.5 and 1.0 gm/kg/Infusion by alternating the two doses in the maintenance treatment of 11 patients with ITP. There was no significant difference in the duration of response following single IVGG infusion between these two doses. This finding suggests that there is no advantage to the greater dose of IVGG and will substantially lower the cost of as well as facilitating IVGG maintenance treatment. It was not possible to determine whether a lower dose would impact adversely on the curative potential of IVGG. This effect of IVGG has never been proved and, if it exists, may be mediated by a different mechanism from the acute platelet response.
Exchange Transfusion for Massive Liver Necrosis
Authors: Donald J. Ritt
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Within the past five months, we have cared for five patients with acute hepatic coma occurring as a result of massive hepatic necrosis. This letter is written to relate our experiences because of considerable current interest in the treatment of this problem. Exchange transfusions were performed in four of the patients, of whom one survived. He is a 48-year-old white man who ingested a pint of carbon tetrachloride in a suicide attempt and became comatose four days later. His peak serum glutamic pyruvic transaminase (SGOT) was &gt; 6,500 units and peak prothrombin time 30 seconds ( 12 second control). He received an exchange transfusion of 6 liters of whole blood and awoke 27 hours later at a time when his prothrombin time was 26 seconds and bilirubin level was climbing. Additional therapy included neomycin but no steroids. The other three patients who did not survive had the following
Simultaneous Endoscopic and Radiological Examination of the Colon
Authors: U. Rabast
Journal: Endoscopy (1997)

See also: Reply to RabastEndoscopy 1997; 29(04): 330-330DOI: 10.1055/s-2007-1004340 See also: Simple Endoscopic Treatment of a Granular-Cell Tumor of the EsophagusEndoscopy 1996; 28(08): 730-731DOI: 10.1055/s-2007-1009133
Effects of nutritional factors on metabolism of dietary cadmium at levels similar to those of man.
Authors: M R Fox, R M Jacobs, A O Jones, B E Fry
Journal: Environmental Health Perspectives (1979)

Several nutrients are known to affect cadmium toxicity, but little is known about the effect of dietary nutrient levels on absorption and tissue retention of cadmium at low dietary levels, similar to those of man. Feeding gradedlevels of zinc in a casein-gelatin diet to young Japanese quail with 109Cd (as the chloride) and 0.062 ppm added cadmium decreased the cadmium concentrations in the proventriculus-ventriculus, duodenum, jejunum-ileum, and the liver, but not in the kidney. Zinc also affected some zinc, iron, manganese, and copper tissue levels. Different tissue concentration patterns of cadmium and essential minerals were obtained with two purified control diets, one based on casein-gelatin and the other on soy isolate as the principal protein sources. The data show that relatively small dietary changes can markedly affect tissue levels of cadmium and that a low intake of zinc may increase the risk to dietary cadmium exposure. The complexity of the nutrient interrelationships and their effects on cadmium require further study to define mechanisms, which may be similar to those produced by low cadmium intakes in man.
Intramuscular Hemorrhage in Hemophiliacs With Inhibitors
Authors: Pierce E. Scranton
Journal: JAMA (1979)

Any hemorrhage in a hemophilic patient must be regarded as a serious problem. A small percentage of hemophiliacs have an inhibitor that will destroy factor VIII or IX clotting activity, thus making control even more difficult. This occurrence predisposes these patients to joint contractures and deformities secondary to repeated, uncontrolled hemorrhages into muscle compartments and joints. Patients with an inhibitor must, therefore, be recognized, and any bleeding should be treated as an emergency. A combined treatment protocol has been developed by the hematology and orthopedic departments in a effort to achieve early hemorrhage control and prevent subsequent deformity. (<i>JAMA</i>241:2028-2030, 1979)
Randomly Alternating Image Presentation During Laparoscopic Training Leads to Faster Automation to the “Fulcrum Effect”
Authors: None A. Jordan, None G. Gallagher, None McGuigan, None McClure
Journal: Endoscopy (2000)

The aim of this study was to evaluate four training programmes intended to help laparoscopic surgeons automate to the "fulcrum effect".A total of 32 participants (16 men, 16 women), were randomly assigned to one of four different image-viewing conditions: full binocular, y-axis inverted, normal laparoscopic and randomly alternating (between y-axis-inverted and normal laparoscopic). The subjects were requested to perform 10 trials of a simple laparoscopic cutting task, each lasting 2 minutes. Each then completed a 2-minute test under normal laparoscopic imaging conditions.In the final test trial, participants who trained under the randomly alternating imaging conditions (y-axis inverted and normal laparoscopic) performed significantly better than those from the other groups.Training under a randomly alternating viewing condition helps laparoscopic trainees automate to the "fulcrum effect" faster.