The Antibody Response of Rheumatic Fever Subjects to Respiratory Viruses
Authors: York E. Crawford, M. J. Mcnamara
Journal: Annals of Internal Medicine (1962)

Article1 March 1962The Antibody Response of Rheumatic Fever Subjects to Respiratory VirusesYORK E. CRAWFORD, M.S., M. J. MCNAMARAYORK E. CRAWFORD, M.S.Search for more papers by this author, M. J. MCNAMARASearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-3-389 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough a group A streptococcal infection is recognized as being important in the pathogenesis of acute rheumatic fever, the precise role of the causative bacteria remains poorly understood. One finding has been commonly noted, namely, that streptococcal antibodies tend to rise to higher titer in rheumatic fever than in uncomplicated streptococcal infection (1-6). This observation has suggested that antigen-antibody interreaction is a factor in the pathogenesis of acute rheumatic fever (7, 8). A question often posed is whether or not subjects who develop rheumatic fever are immunological hyperreactors who will respond excessively to any antigenic stimulation.Creger, Choy, and Rantz...References1. ANDERSONKUNKELMCCARTY HCHGM: Quantitative antistreptokinase studies in patients infected with group A hemolytic streptococci: a comparison with serum antistreptolysin and gamma globulin levels with special reference to the occurrence of rheumatic fever. J. Clin. Invest. 27: 425, 1948. CrossrefMedlineGoogle Scholar2. RANTZRANDALLRANTZ LAEHH: Antistreptolysin O. A study of this antibody in health and in hemolytic streptococcus respiratory disease in man. Amer. J. Med. 5: 3, 1948. CrossrefMedlineGoogle Scholar3. HARRISHARRIS STN: Serologic response to streptococcal hemolysin and hyaluronidase in streptococcal and rheumatic infection. J. Clin. Invest. 29: 351, 1950. CrossrefMedlineGoogle Scholar4. 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M. A. 126: 481, 1944. CrossrefGoogle Scholar14. ROBINSONCRAWFORDROHOLT JJYEDM: The determination of antistreptolysin O. Amer. J. Clin. Path. 22: 237, 1952. CrossrefMedlineGoogle Scholar15. KOLMERSPAULDINGROBINSON JAEHHW: Approved Laboratory Technic, Appleton-Century-Crofts, Inc., New York, 1951, p. 184. Google Scholar16. CRAWFORDROSENBAUMPIERCEGIBBSMILLER YEMJWEWHLF: Epidemicity of Adenovirus in Naval Recruits with Observations on Their Occurrence with Streptococci and Influenza Viruses as Partners of Infection. Research Project Report No. MR 52 05 04.2, The Bureau of Medicine and Surgery, Navy Department, Washington, D. C., 1960. Google Scholar17. DEMEIOWOOLRIDGEWHITESIDESEAL JLRLJEJR: Epidemic influenza B and C in Navy recruits, 1953-1954. II. Antigenic studies on influenza virus type C. Proc. Soc. Exp. Biol. Med. 88: 436, 1955. CrossrefMedlineGoogle Scholar18. STOLLERMAN GH: Factors that predispose to rheumatic fever. Med. Clin. N. Amer. 44: 17, 1960. CrossrefMedlineGoogle Scholar19. SCHULTZFRANK IPF: The prophylactic use of sulfamethoxypyridazine (Kynex) during a streptococcal epidemic. Amer. J. Med. Sci. 236: 779, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Great Lakes, IllinoisFrom the Divisions of Immunology and Epidemiology, United States Naval Medical Research Unit No. 4, Great Lakes, Illinois (Research Project MR 005.09-1203.2, The Bureau of Medicine and Surgery, Navy Department, Washington, D. C.).The opinions and assertions expressed herein are those of the authors and cannot be construed as indicating endorsement or approval by the Navy Department or the Naval Service at large.Requests for reprints should be addressed to York E. Crawford, Immunology Division, Naval Medical Research Unit No. 4, United States Naval Hospital, Great Lakes, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe pathogenetic basis of animal and human autoimmune diseaseRheumatism and Arthritis Review of American and English Literature of Recent Years (Sixteenth Rheumatism Review)CHARLEY J. SMYTH, M.D., F.A.C.P., ROGER L. BLACK, M.D., CHARLES CHRISTIAN, M.D., MACK L. CLAYTON, M.D., F.A.C.S., DONALD F. HILL, M.D., F.A.C.P., JOSEPH LEE HOLLANDER, M.D., F.A.C.P., WILLIAM M. MIKKELSEN, M.D., F.A.C.P., MAX M. MONTGOMERY, M.D., F.A.C.P., CARL M. PEARSON, M.D., F.A.C.P., HUGH A. SMYTHE, M.D., F.R.C.P. (C), L. EMMERSON WARD, M.D., F.A.C.P., HOWARD J. WEINBERGER, M.D., F.A.C.P. 1 March 1962Volume 56, Issue 3Page: 389-396KeywordsAntibody productionAntigensBacteriaEpidemiologyGroup A streptococcal infectionImmunologyPathogenesisRheumatic feverStreptococcal infectionsSurgery Issue Published: 1 March 1962 PDF DownloadLoading ...