tbuckley/cabot-search huggingface dataset:
POTASSIUM FLUORID AS A PRESERVATIVE FOR BLOOD
Authors: Ralph H. Major
Journal: JAMA (1923)

The need of a satisfactory preservative in specimens of blood for chemical studies has long been felt in this clinic. This need has become greater with the increasing use of insulin. Diabetic patients are often admitted to the hospital at hours when it is not possible to make estimations of the blood sugar and carbon dioxid, however desirable such examinations may be, and experience has shown us that specimens of blood collected in oxalate solution may be unsatisfactory for study the following day, even when kept on ice. The need of a preservative is also felt when the physician without adequate laboratory facilities wishes to mail a specimen of blood for determination of. the sugar and carbon dioxid tension. We have been experimenting recently with various substances which are described as having an antiferment action and which should thus either delay or prevent the glycolytic activity of the blood. Some
Conducting Clinical Research: A Practical Guide for Physicians, Nurses, Study Coordinators, and Investigators
Authors: Roger J. Lewis
Journal: Annals of Internal Medicine (2007)

Medical Writings: Book Notes3 April 2007Conducting Clinical Research: A Practical Guide for Physicians, Nurses, Study Coordinators, and InvestigatorsRoger J. Lewis, MD, PhDRoger J. Lewis, MD, PhDFrom Harbor Medical Center, Torrance, California, and David Geffen School of Medicine and The Los Angeles Biomedical Research Institute, Los Angeles, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-7-200704030-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Stone J. 427 pages. Cumberland, MD: Mountainside MD Pr; 2006. $69.95. ISBN 097491780X. Order at www.conductingclinicalresearch.com.Field of medicine: Clinical research, especially for-profit pharmaceutical research.Format: Softcover book.Audience: Physicians, study nurses, study coordinators, and nonphysician scientists.Purpose: To “provide an overview of how research is conducted for drug companies and how (one) might become involved.”Content: This guide, written from the point of view of a site principal investigator contracting with a for-profit pharmaceutical sponsor, successfully covers a broad range of topics related to the implementation of clinical trials of pharmaceutical products. Practical considerations for identifying sponsors and potential ... Author, Article, and Disclosure InformationAffiliations: From Harbor Medical Center, Torrance, California, and David Geffen School of Medicine and The Los Angeles Biomedical Research Institute, Los Angeles, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 April 2007Volume 146, Issue 7Page: 544KeywordsAdverse eventsClinical trialsDrug research and developmentDrugsSafetySafety studiesScientistsSoftware tools ePublished: 3 April 2007 Issue Published: 3 April 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
COMPULSION NEUROSIS WITH CACHEXIA (ANOREXIA NERVOSA)
Authors: FRANKLIN S. DUBOIS
Journal: American Journal of Psychiatry (1949)

Anorexia nervosa dramatically demonstrates the inseparability of mind and body and is a classic example of a psychosomatic disorder. It is primarily a psychic and secondarily a somatic disturbance. Inasmuch as the personality reaction of the individual suffering from anorexia nervosa more nearly conforms to compulsion neurosis than that of any other psychiatric disorder and, in addition, has cachexia rather than anorexia as a leading symptom, it is suggested that the illness would be more accurately termed compulsion neurosis with cachexia. Although definitive data as to etiology are not available, evidence presented indicates that constitutional defect probably predisposes to the illness, which becomes manifest at puberty or shortly thereafter because of severe and deep psychological conflicts centering in the family constellation. The dynamics of these conflicts are discussed and the conclusion drawn that the patient's basic difficulty lies in her more intimate interpersonal relationships. Adequate physiological and psychological treatment, described in detail, offers a reasonably good prognosis, although the tendency to relapse is great.
Nursing Home Placement and the Demented Patient
Authors: DIANE E. MEIER
Journal: Annals of Internal Medicine (1986)

The decision to seek nursing home placement will be faced with increasing frequency as the population over age 65 continues to grow. Although this is a difficult juncture under any circumstances, the ethical issues accompanying such a move for persons of diminished competence are unusually complex and require involvement of many concerned parties. In a typical case presentation, the social context informing these decisions is described, including bias against the aged, perceptions of scarce resources in health care, and the problematic role of the courts. The perspectives and moral obligations of the patient, family, and health professionals are discussed and contrasted to clarify the sometimes conflicting roles and needs of those three parties. A stepwise process of decision making before nursing home placement is offered in an effort to choose the least restrictive alternative for the patient while respecting the needs of concerned persons.
System Tracks Drug-Resistant Bacteria in the Body
Authors: Tracy Hampton
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The role of exposure in emotional responses to music
Authors: E. Glenn Schellenberg
Journal: Behavioral and Brain Sciences (2008)

Abstract A basic aspect of emotional responding to music involves the liking for specific pieces. Juslin &amp; Västfjäll (J&amp;V) fail to acknowledge that simple exposure plays a fundamental role in this regard. Listeners like what they have heard but not what they have heard too often. Exposure represents an additional mechanism, ignored by the authors, that helps to explain emotional responses to music.
Antibiotic prophylaxis for urinary tract infections after removal of urinary catheter: meta-analysis
Authors: J. Marschall, C. R. Carpenter, S. Fowler, B. W. Trautner
Journal: BMJ (2013)

<b>Objective</b> To determine whether antibiotic prophylaxis at the time of removal of a urinary catheter reduces the risk of subsequent symptomatic urinary tract infection<b>.</b> <b>Design</b> Systematic review and meta-analysis of studies published before November 2012 identified through PubMed, Embase, Scopus, and the Cochrane Library; conference abstracts for 2006-12 were also reviewed. <b>Inclusion criteria</b> Studies were included if they examined antibiotic prophylaxis administered to prevent symptomatic urinary tract infection after removal of a short term (≤14 days) urinary catheter. <b>Results</b> Seven controlled studies had symptomatic urinary tract infection after catheter removal as an endpoint; six were randomized controlled trials (five published; one in abstract form) and one was a non-randomized controlled intervention study. Five of these seven studies were in surgical patients. Studies were heterogeneous in the type and duration of antimicrobial prophylaxis and the period of observation. Overall, antibiotic prophylaxis was associated with benefit to the patient, with an absolute reduction in risk of urinary tract infection of 5.8% between intervention and control groups. The risk ratio was 0.45 (95% confidence interval 0.28 to 0.72). The number needed to treat to prevent one urinary tract infection was 17 (12 to 30). <b>Conclusions</b> Patients admitted to hospital who undergo short term urinary catheterization might benefit from antimicrobial prophylaxis when the catheter is removed as they experience fewer subsequent urinary tract infections. Potential disadvantages of more widespread antimicrobial prophylaxis (side effects and cost of antibiotics, development of antimicrobial resistance) might be mitigated by the identification of which patients are most likely to benefit from this approach.
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death
Authors: Monica K Wetzel-Smith, Julie Hunkapiller, Tushar R Bhangale, Karpagam Srinivasan, Janice A Maloney, Jasvinder K Atwal, Susan M Sa, Murat B Yaylaoglu, Oded Foreman, Ward Ortmann, Nisha Rathore, David V Hansen, Marc Tessier-Lavigne, Richard Mayeux, Margaret Pericak-Vance, Jonathan Haines, Lindsay A Farrer, Gerard D Schellenberg, Alison Goate, Timothy W Behrens, Carlos Cruchaga, Ryan J Watts, Robert R Graham
Journal: Nature Medicine (2014)
Response to Letters Regarding Article, “Arterial Stiffness and Cardiovascular Events: The Framingham Heart Study”
Authors: Gary F. Mitchell, Shih-Jen Hwang, Ramachandran S. Vasan, Martin G. Larson, Daniel Levy, Emelia J. Benjamin, Michael J. Pencina, Naomi M. Hamburg, Joseph A. Vita
Journal: Circulation (2010)
HERPES FACIALIS IN SCARLET FEVER
Authors: J. D. ROLLESTON
Journal: British Journal of Dermatology (1910)

Journal Article HERPES FACIALIS IN SCARLET FEVER Get access J. D. ROLLESTON, M.D. J. D. ROLLESTON, M.D. Assistant Medical Officer, Grove Fever Hospital, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 22, Issue 10, 1 October 1910, Pages 309–312, https://doi.org/10.1111/j.1365-2133.1910.tb16590.x Published: 01 October 1910
Treatment of Burns by Envelope Irrigation
Authors: J. W. Hannay
Journal: BMJ (1941)

While no single method for the local treatment of burns has been found universally satisfactory and acceptable, the technique described by Bunyan (1940) of sealing the affected part in a coated silk envelope and irrigating with electrolytic sodium hypochlorite merits a thorough and critical trial. In the past six months 16 cases have been treated by this means at the London Hospital and 8 by . other methods. Two were caused by electricity; the rest were due to the commoner agents encountered in civil practice and to wartime incendiary bombs. When the burns were multiple, as was often the case, different methods were used on the separate lesions and comparisons made between them.
Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell–attracting chemokine (CTACK) levels in allergic diseasesTARC and CTACK are disease-specific markers for atopic dermatitis
Authors: DirkJan Hijnen, Marjolein de Bruin-Weller, Bert Oosting, Cristina Lebre, Esther de Jong, Carla Bruijnzeel-Koomen, Edward Knol
Journal: Journal of Allergy and Clinical Immunology (2004)
Bone marrow trephine biopsy findings in essential thrombocythemia
Authors: Rashpal Flora, Tyler Lloyd, Asad Luqmani, Kikkeri N. Naresh
Journal: American Journal of Hematology (2011)

A woman in her mid-30s presented with unexplained mild splenomegaly (17 cm in greatest dimension by ultrasound scan). Her hemoglobin was 13.8 g/L. Her platelet count was initially 586 × 109/L and remained relatively steady over the following 7 years ranging between 416 and 586 × 109/L. Her white cell count and neutrophil count was only minimally increased on intermittent occasions during these years. The peripheral blood film showed increased platelet anisocytosis and some giant platelets with no evidence of a leucoerythroblastic picture. The marrow aspirate showed an increased number of megakaryocytes (a), which were large with hyperlobulated nuclei (b,c). The erythroid and myeloid lineages showed normal maturation. Pyrosequencing revealed JAK2 V617F mutation (in 24% of total DNA). No cytogenetic abnormalities were identified and the BCR–ABL fusion gene was not detected. The bone marrow trephine biopsy was normocellular to slightly hypercellular with a cellularity of about 60–70%. The megakaryocytes were increased in number with some present in clusters (d). A good proportion of megakaryocytes showed enlargement and hyperlobulation (e–k) with some nuclei showing a staghorn configuration. The erythroid and myeloid cells showed a normal pattern of maturation. The marrow reticulin was not increased. The appearances were consistent with essential thrombocythemia (ET). The characteristic finding in ET is the presence of increased megakaryocytes with hyperlobulated nuclei that have been described as having a staghorn configuration. The clinical findings excluded any reactive causes of thrombocytosis. The JAK2 V617F mutation was detected in this case, and although it can be present in about half of all cases of ET (the MPL W515K/L mutation present in another 1–2%), it is not specific and can be detected in other chronic myeloproliferative neoplasms. Morphologically, the absence of highly atypical megakaryocytes made the prefibrotic stage of primary myelofibrosis less likely, and the absence of significant abnormalities in the erythroid and myeloid cell lineages helped rule out other myeloproliferative neoplasms such as polycythemia vera and chronic myelogenous leukemia. Despite the presence of splenomegaly, the clinical course has been uneventful, and the patient has required no therapeutic intervention to date. Together, with the absence of anemia in this patient, these features are consistent with ET [1]. Furthermore, a small proportion of patients with ET present or develop splenomegaly during the course of the disease [2].
Appropriate sensing of ventricular fibrillation after failed shocks in a transvenous cardioverter-defibrillator system.
Authors: J R Ellis, D T Martin, F J Venditti
Journal: Circulation (1994)

BACKGROUND Reduction in R-wave amplitude immediately after defibrillation shocks in an integrated shock/sense transvenous cardioverter-defibrillator (TCD) lead system has prompted concerns regarding adequate sensing after failed shocks. We therefore studied redetection characteristics for ventricular fibrillation after unsuccessful defibrillation shocks in a TCD system to determine if these observations have clinical relevance. METHODS AND RESULTS Fifty patients with this shock/sense TCD lead system underwent conversion testing of their TCD at several time intervals. There were a total of 142 failed shocks events recorded, including 10, 15, 70, and 47 events at implantation, predischarge, and 2- and 6-month testing, respectively. Initial detection time (IDT) and redetection time (RDT) for ventricular fibrillation were measured from event markers for all unsuccessful defibrillation shocks. To assess the effect of failed shocks on electrogram quality, 54 failed shock episodes were evaluated in 37 of the 50 patients by measuring electrograms during VF before and after shock. Mean RDT for the entire group was 5.3 +/- 3.5 seconds compared with an IDT of 4.5 +/- 3.3 seconds (P = NS). There were no significant differences between IDT and RDT at implantation or any follow-up testing period, despite a significant decline in R-wave amplitude from 8.1 +/- 3.5 to 6.8 +/- 2.8 mV (P &lt; .0001) measured 3 to 6 seconds after shock delivery. Analysis of 8 individuals with any extended RDT (&gt; or = 10 seconds) showed no significant differences in clinical or implantation characteristics when compared with 42 individuals without extended RDT. CONCLUSIONS In this integrated shock/sense TCD lead system, unsuccessful shock delivery has no significant effect on redetection of ventricular fibrillation at device implantation or up to 6 months of follow-up, despite an observed reduction in postshock R-wave amplitude. Therefore, the reported reduction in electrogram quality after a shock is of no practical importance because sensing of ventricular fibrillation does not appear to be compromised in this particular TCD system. Whether this applies to other implantable cardioverter-defibrillator pulse generators and lead systems with different sensing characteristics requires further evaluation.
Causes and Metabolic Consequences of Fatty Liver
Authors: Norbert Stefan, Konstantinos Kantartzis, Hans-Ulrich Häring
Journal: Endocrine Reviews (2008)

Type 2 diabetes and cardiovascular disease represent a serious threat to the health of the population worldwide. Although overall adiposity and particularly visceral adiposity are established risk factors for these diseases, in the recent years fatty liver emerged as an additional and independent factor. However, the pathophysiology of fat accumulation in the liver and the cross-talk of fatty liver with other tissues involved in metabolism in humans are not fully understood. Here we discuss the mechanisms involved in the pathogenesis of hepatic fat accumulation, particularly the roles of body fat distribution, nutrition, exercise, genetics, and gene-environment interaction. Furthermore, the effects of fatty liver on glucose and lipid metabolism, specifically via induction of subclinical inflammation and secretion of humoral factors, are highlighted. Finally, new aspects regarding the dissociation of fatty liver and insulin resistance are addressed.
837 COMPARING OUTCOMES IN PATIENTS WITH TREATMENT NAIVE CHRONIC HEPATITIS C TREATED WITH 2 TYPES OF PEGYLATED INTERFERON, WHEN MATCHED FOR AGE, BMI, GENOTYPE AND FIBROSIS SCORES
Authors: K. Venugopal, L. Mollison, S. Miczkova, M. Bulsara, W. Cheng, N. Kontorinis
Journal: Journal of Hepatology (2008)
HEALTH RELATED QUALITY OF LIFE AND FUNCTIONAL CLASS ARE INDEPENDENTLY RELATED TO OUTCOMES IN UNSELECTED OUTPATIENTS WITH HEART FAILURE: INSIGHTS FROM THE STUDY OF ANEMIA IN A HEART FAILURE POPULATION (STAMINA-HFP) REGISTRY
Authors: Jalal K. Ghali, Jun R. Chiong, Javed Butler, William G. Cotts, Stephanie . H. Dunlap, J. Herbert Patterson, Ron M. Oren, Ileana L. Piña, Douglas D. Schocken, Todd A. Schwartz, Kirkwood F.F. Adams
Journal: Journal of the American College of Cardiology (2010)
A Prospective Clinical and Immunologic Analysis of Patients with Serum Sickness
Authors: Thomas J. Lawley, Leonard Bielory, Pedro Gascon, Kim B. Yancey, Neal S. Young, Michael M. Frank
Journal: New England Journal of Medicine (1984)

We prospectively evaluated the clinical and immunologic features of serum sickness in 12 patients with bone-marrow failure treated for 10 days with intravenous infusions of horse antithymocyte globulin. Eleven of the 12 patients had signs and symptoms of serum sickness 8 to 13 days after beginning therapy with antithymocyte globulin. Eleven patients (including 10 of 11 with signs and symptoms of serum sickness) acquired circulating immune complexes, with peak levels occurring at 10 to 12 days. Serum C4 and C3 levels fell precipitously, with nadirs on the 10th day. Plasma levels of C3a anaphylatoxin were elevated in the four patients in whom it was measured. Eight of the 11 patients with signs and symptoms of serum sickness had a characteristic serpiginous erythematous and purpuric eruption on the hands and feet at the junction of palmar and plantar skin. Direct immunofluorescence of skin lesions revealed immune deposits (IgM, IgE, IgA, or C3) in the blood vessels of three of five patients. This study documents the immunopathology of serum sickness in human beings and describes a cutaneous marker for the disease.
Predicting mortality from cervical cancer.
Authors: E. J. Buxton, M. I. Shafi, R. Chenoy, D. M. Luesley
Journal: BMJ (1992)

believe total withdrawal of the capsule formulation is possible by the end of the year.We will be passing our results to the Advisory Council on the Misuse of Drugs and support the argument that the continued availability of temazepam tablets and elixir will provide adequate formulations for all patients.
The Sky Remembers
Authors: E. M. McMahon
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acute Rheumatic Fever in Adults
Authors: Anthony L. Barnert
Journal: JAMA (1975)

Acute rheumatic fever (ARF) in 53 adults was characterized by a severe, febrile migratory polyarthritis involving primarily large joints in the lower extremities, with evidence of an antecedent streptococcal infection. Carditis, present in only eight (15%) of the adults, was mild and transient. The characteristic abnormality in laboratory findings was an erythrocyte sedimentation rate (Westergren) greater than 100 mm/hr. Response to high-dose aspirin therapy was prompt and dramatic in all patients. Mild andevanescent abnormalities of both renal function and hepatic function (not aspirin-mediated) were detected in 51% and 64%, respectively. A common disorder in San Antonio, ARF has distinctive symptoms. It can be readily diagnosed and promptly treated. In the adult, it is almost exclusively a syndrome of events severe but transient in the joints, and mild and transient in the heart, kidneys, and liver.