High-Dosage Vitamin E Supplementation and All-Cause Mortality
Authors: Koyamangalath Krishnan, Sharon Campbell, William L. Stone
Journal: Annals of Internal Medicine (2005)

Letters19 July 2005High-Dosage Vitamin E Supplementation and All-Cause MortalityKoyamangalath Krishnan, MD, Sharon Campbell, PhD, and William L. Stone, PhDKoyamangalath Krishnan, MDFrom The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, and East Tennessee State University, Johnson City, TN 37614., Sharon Campbell, PhDFrom The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, and East Tennessee State University, Johnson City, TN 37614., and William L. Stone, PhDFrom The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, and East Tennessee State University, Johnson City, TN 37614.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-2-200507190-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:There are several flaws in the meta-analysis by Miller and colleagues (1), including erroneous interpretation of the pooled trials of α-tocopherol and lack of clarity in vitamin E nomenclature. The analysis includes trials from many time periods, with different trial designs, doses and combinations, and end points that make comparisons difficult and fallacious. Participants in several of the trials had significant medical conditions, such as coronary artery disease, end-stage renal disease, diabetes mellitus, Parkinson disease, and Alzheimer disease. Given this heterogeneity in the participant pool, we would consider it presumptuous to draw solid conclusions of the magnitude ...References1. Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142:37-46. [PMID: 15537682] LinkGoogle Scholar2. Wagner KH, Kamal-Eldin A, Elmadfa I. Gamma-tocopherol—an underestimated vitamin? Ann Nutr Metab. 2004;48:169-88. [PMID: 15256801] CrossrefMedlineGoogle Scholar3. Hensley K, Benaksas EJ, Bolli R, Comp P, Grammas P, Hamdheydari L, et al. New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicine. Free Radic Biol Med. 2004;36:1-15. [PMID: 14732286] CrossrefMedlineGoogle Scholar4. Stone WL, Krishnan K, Campbell SE, Qui M, Whaley SG, Yang H. Tocopherols and the treatment of colon cancer. Ann N Y Acad Sci. 2004;1031:223-33. [PMID: 15753148] CrossrefMedlineGoogle Scholar5. Campbell S, Stone W, Whaley S, Krishnan K. Development of gamma (gamma)-tocopherol as a colorectal cancer chemopreventive agent. Crit Rev Oncol Hematol. 2003;47:249-59. [PMID: 12962899] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, and East Tennessee State University, Johnson City, TN 37614.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality Edgar R. Miller III , Roberto Pastor-Barriuso , Darshan Dalal , Rudolph A. Riemersma , Lawrence J. Appel , and Eliseo Guallar High-Dosage Vitamin E Supplementation and All-Cause Mortality Harri Hemilä High-Dosage Vitamin E Supplementation and All-Cause Mortality Wee-Shiong Lim , Rajka Liscic , Chengjie Xiong , and John C. Morris High-Dosage Vitamin E Supplementation and All-Cause Mortality Connie Marras , Anthony E. Lang , David Oakes , Michael P. McDermott , Karl Kieburtz , Ira Shoulson , Caroline M. Tanner , and Stanley Fahn High-Dosage Vitamin E Supplementation and All-Cause Mortality Simin Nikbin Meydani , Joseph Lau , Gerard E. Dallal , and Mohsen Meydani High-Dosage Vitamin E Supplementation and All-Cause Mortality Kent J. DeZee , William Shimeall , Kevin Douglas , and Jeffrey L. Jackson High-Dosage Vitamin E Supplementation and All-Cause Mortality Antonio M. Possolo High-Dosage Vitamin E Supplementation and All-Cause Mortality Ishwarlal Jialal and Sridevi Devaraj High-Dosage Vitamin E Supplementation and All-Cause Mortality Thomas Carter High-Dosage Vitamin E Supplementation and All-Cause Mortality Joseph E. Baggott High-Dosage Vitamin E Supplementation and All-Cause Mortality Edgar R. Miller III , Lawrence J. Appel , Eliseo Guallar , and Roberto Pastor-Barriuso Brief Communication: The Prevalence of High Intake of Vitamin E from the Use of Supplements among U.S. Adults Earl S. Ford , Umed A. Ajani , and Ali H. Mokdad An Editorial Update: Annus horribilis for Vitamin E Eliseo Guallar , Daniel F. Hanley , and Edgar R. Miller III High-Dosage Vitamin E Supplementation and All-Cause Mortality David H. Blatt and William A. Pryor Metrics Cited byThe therapeutic effect of silymarin in the treatment of nonalcoholic fatty diseaseVitamin E for the treatment of E-antigen-positive chronic hepatitis B in paediatric patients: results of a randomized phase 2 controlled studyVitamin E for the treatment of children with hepatitis B e antigen-positive chronic hepatitis: A systematic review and meta-analysisPossible role of tocopherols in the modulation of host microRNA with potential antiviral activity in patients with hepatitis B virus-related persistent infection: a systematic reviewEffect of Dietary Vitamin A on Reproductive Performance and Immune Response of Broiler BreedersAntioxidants in Food: Mere Myth or Magic Medicine?Nutrient plasma levels achieved during treatment that reduces noise-induced hearing lossBioactive Nutritional Supplements for Chronic Kidney Disease: Potential Cost BenefitsNo evidence supports vitamin E indiscriminate supplementationDecision Analysis Supports the Paradigm That Indiscriminate Supplementation of Vitamin E Does More Harm than GoodAdverse effects of vitamin E by induction of drug metabolismCellular, molecular and clinical aspects of vitamin E on atherosclerosis preventionVitamin E Regulatory MechanismsThe Roles of α‐Vitamin E and Its Analogues in Prostate Cancer 19 July 2005Volume 143, Issue 2Page: 151KeywordsAttentionCardiovascular diseasesNutrientsOilsParkinson diseaseRenal failureStable coronary artery diseaseStatistical dataVitamin E ePublished: 19 July 2005 Issue Published: 19 July 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...