tbuckley/cabot-search huggingface dataset:
Study Tracks Children’s Brain Development
Authors: Tracy Hampton
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemiological Application of the Fluorescent Antibody Technique
Authors: John D. Nelson, Jo Anne Whitaker, Billye Hempstead, Maxine Harris
Journal: JAMA (1961)

Four cases of diarrhea due to enteropathogenic<i>Escherichia coli</i>developed in a nursery for premature infants where no diarrheal disease had occurred for several months. Rectal swabs of the 36 infants and 32 personnel in the nursery were examined by standard culture methods and by the fluorescent antibody technique. Another 5 infants and 1 student nurse were found by fluorescent antibody staining to be colonized with the same organism, but cultures from feces were positive in only 2 of the colonized infants. The epidemic was controlled by isolating infants who harbored the organism, removing the nurse-carrier, and treating all infants with neomycin sulfate. The specificity, sensitivity, and rapidity of fluorescent antibody staining indicate that this method may be more useful than standard culture methods in epidemiological investigations.
Style Analysis: Samuel Johnson
Authors: Lester S. King
Journal: JAMA (1968)

Samuel Johnson, immortalized by Boswell, is very little read today. In his own lifetime (1709-1784) he achieved great renown as an essayist and critic, poet and lexicographer. Today he seems ponderous and dull. The modern reader, wading through the heavy prose, might concede that many good thoughts are hidden there, but they seem too well hidden. Even in his own day Johnson was not considered a sprightly writer, but he did exert a magisterial authority and helped to form the essay into a major category of English literature. An essayist might "play" with an idea, unravel the various implications and illustrate them by references to classical and modern literature, create a bit of writing to entertain and perhaps instruct. The finished product often resembled a soufflé, light and airy, flavored by the author's personality, a joy when successful, somewhat soggy when unsuccessful. Indeed, many of the 18th century essays are
Energy Expenditure With Indoor Exercise Equipment-Reply
Authors: Martin D. Hoffman
Journal: JAMA (1996)

<h3>In Reply.</h3> —We hope the opinions of Dr Yannios and Dr Rippe that our article was "potentially counterproductive to promoting fitness" and "a disservice to the public" were not shared by other readers of<i>JAMA</i>. We are professionally devoted to exercise science research and clinical activities to help individuals improve fitness and function. We also believe that our mission as scientists is to carefully perform investigations examining testable hypotheses and to accurately report the results. Interpretation of the results by the media and by other professionals is beyond our control. Dr Yannios states that Saltin and Astrand<sup>1</sup>showed "V0<sub>2</sub>maximum at equivalent RPE's are highest in cross-country skiing, followed by running and cycling, then rowing." In actuality, that study was not a comparison of different exercise modes, but rather a comparison of maximal oxygen uptakes among different types of athletes. Additionally, RPE was not reported in this work nor
Muscleblind-like 1 (Mbnl1) regulates pre-mRNA alternative splicing during terminal erythropoiesis
Authors: Albert W. Cheng, Jiahai Shi, Piu Wong, Katherine L. Luo, Paula Trepman, Eric T. Wang, Heejo Choi, Christopher B. Burge, Harvey F. Lodish
Journal: Blood (2014)
Extravasation of macromolecules and possible trapping of transforming growth factor-β in venous ulceration
Authors: H. R. HIGLEY, G. A. KSANDER, C. O. GERHARDT, V. FALANGA
Journal: British Journal of Dermatology (1995)

The pathogenesis of venous ulceration is thought to involve formation of pericapillary fibrin cuffs as a result of venous hypertension, and a recent hypothesis suggests that extravasated plasma proteins may bind or trap growth factors. We have compared the tissue distribution of fibrin cuffs, plasma proteins, procollagen, and transforming growth factors (TGF‐β1 and TGF‐β2) within venous ulcers and normally healing graft donor sites. In venous ulcers, the papillary dermis and the ulcer bed contained convoluted capillaries with phosphotungstic acid haematoxylin‐positive pericapillary fibrin cuffs. By immunohistochemical staining, the cuffs were positive for actin, and contained massively redundant lamellae of basement membrane material which stained positive for type IV collagen. Extravasated factor XHIa and α2‐macroglobulin were present within the fibrin cuffs. increased numbers of type I procollagen positive fibroblasts, and increased TGF‐β1 immunoreactiv‐ity were present within the fibrin cuffs, but not in the provisional matrix in the ulcer bed around the cuffs. In contrast, in normally healing graft donor sites, tortuous capillaries and fibrin cuffs were absent, factor XHIa and α1‐macroglobulin were restricted to the lumina of vessels, and procollagen and TGF‐/V immunoreactivity were present within the granulation tissue and adjacent dermal matrix at the wound margin. These observations suggest that growth factors critical in wound healing, such as TGF‐β, are present within venous ulcers, but are abnormally distributed. Their distribution within fibrin cuffs and co‐localization with extravasated plasma proteins, particularly α2‐macro‐globulin, which is a recognized scavenger molecule for TGF‐β and other growth factors, provides evidence for a possible 'trapping' of growth factors in venous ulcers.
P3-132: A Phase II trial of docetaxel, oxaliplatin and bevacizumab as first–line therapy of unresectable, locally advanced or recurrent and/or metastatic (Stage IIIB/IV) non–small cell lung cancer (NSCLC)– initial safety analysis
Authors: Luis E. Raez, William Babcock, Nicholas Sarlis, Khaled Tolba, Timothy Webb, Rogelio Brito, Robert Asbury, Melissa Karr, Edgardo Santos
Journal: Journal of Thoracic Oncology (2007)
S98 BMPR-II mutations do not predispose to pulmonary arterial hypertension in a mouse model of schistosomiasis
Authors: A. Crosby, E. Soon, F. Jones, M. Southwood, B. Dunmore, D. Dunne, N. W. Morrell
Journal: Thorax (2011)

Schistosomiasis is the worldwide leading cause of pulmonary arterial hypertension (PAH) and is particularly prevalent in the third-world. More than 80% of patients with PAH in the western world have a mutation in bone morphogenetic protein type-II receptor (BMPR-II), which is a member of the transforming growth receptor-β (TGF-b) superfamily and is important in cell proliferation and differentiation. The aim of the study was to determine if mice with a heterozygous null mutation in BMPR-II are more susceptible to schistosomiasis–induced PAH, compared to wild-type littermates. <h3>Methods</h3> Wild-type and mutant C56/BL6 mice were infected percutaneously with a low dose of <i>S mansoni</i>. At 17 weeks post-infection right ventricular systolic pressure (RVSP) and right ventricular (RV) hypertrophy, liver and lung egg counts and body weight were measured. Pulmonary vascular remodelling was assessed by morphometry, following immunohistochemistry. Human and mouse pulmonary arterial smooth muscle cells (PASMC) were cultured with <i>S mansoni</i> eggs for 24 h. At 24 h the expression of cytokines in PASMC were measured by qPCR and cytokine levels in the cell supernatant were measured by ELISA. <h3>Measurements and Main results</h3> At 17 weeks post-infection there was no significant difference in RVSP, the degree of RV hypertrophy, liver weight or body weight between wild-type or mutant mice. However, 33% of the mutant mice died prematurely. After 24 h co-culture with eggs both mouse and human PASMC showed an increase in cytokine expression and cytokine release. More specifically we saw an increase in IL-6, Kc (mouse homologue of IL-8) and IL-13 expression and an increase in IL-6 and Kc secretion. We also saw an increase in PASMC proliferation, determined by Ki67. There was a suggestion that PASMC from mutant mice may display an increase in cytokine response to egg stimulation. <h3>Conclusions</h3> This study has shown that BMPR-II mutations do not predispose to schistosomiasis-induced PAH. We have also shown that PASMC respond to <i>S mansoni</i> eggs by an increase in expression and release of inflammatory cytokines. These may play a part in inducing pulmonary vascular remodelling by stimulating PASMC proliferation. However, this affect was not significantly enhanced by BMPR-II mutations.
Serum Folate and Risk of Fatal Coronary Heart Disease-Reply
Authors: Howard I. Morrison, Douglas Schaubel, Marie Desmeules, Donald T. Wigle
Journal: JAMA (1996)

In Reply.  —Dr Braun is correct in indicating the RR for coronary heart disease for the lowest folate level studied was statistically significant ( P =.04) for women, but not for men. However, the test for trend was statistically significant for both men and women. Although stratum-specific RRs were higher for women compared with men, the 95% CIs around the point estimates for men and women overlapped. Moreover, a comparison of the sex-specific rate ratios is not the most appropriate means to assess interaction. To formally test the  of sex, folate, and coronary heart disease, we compared the goodness-of-fit of a model that incorporated this  with one that did not. The deviances were 581.76 and 584.53 for the interaction and no-interaction models, respectively. This difference can be assumed to follow a X 2 distribution with degrees of freedom equal to the difference in the number of independent parameters in the 2
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells
Authors: Eva Martinez-Garcia, Relja Popovic, Dong-Joon Min, Steve M. M. Sweet, Paul M. Thomas, Leonid Zamdborg, Aaron Heffner, Christine Will, Laurence Lamy, Louis M. Staudt, David L. Levens, Neil L. Kelleher, Jonathan D. Licht
Journal: Blood (2010)
LDL-Apheresis Atherosclerosis Regression Study (LAARS)
Authors: Abraham A. Kroon, Wim R.M. Aengevaeren, Tjeerd van der Werf, Gerard J.H. Uijen, Johan H.C. Reiber, Albert V.G. Bruschke, Anton F.H. Stalenhoef
Journal: Circulation (1996)

Intensive lipid lowering may retard the progression of coronary atherosclerosis. LDL-apheresis has the potential to decrease LDL cholesterol to very low levels. To assess the effect of more aggressive lipid lowering with LDL-apheresis, we set up a randomized study in men with hypercholesterolemia and severe coronary atherosclerosis.For 2 years, 42 men were treated with either biweekly LDL-apheresis plus medication or medication alone. In both groups a dose of simvistatin of 40 mg per day was administered. Baseline (mean+/-SD) LDL cholesterol was 7.8+/-1.9 mmol x L(-1) and 7.9+/-2.3 mmol x L(-1) in the apheresis and medication groups, respectively. The mean reduction in LDL cholesterol was 63% (to 3.0 mmol x L(-1)) and 47% (to 4.1 mmol x L(-1)), respectively. Primary quantitative coronary angiographic end points were changes in average mean segment diameter and minimal obstruction diameter. No differences between the apheresis and medication groups were found in mean segment diameter (-0.01+/-0.16 mm versus 0.03+/-0.16 mm, respectively) or in minimal obstruction diameter (0.01+/-0.13 mm versus 0.01+/-0.11 mm, respectively), expressed as means per patient. On the basis of coronary segment, mean percent stenosis of all lesions showed a tendency to decrease; only in the apheresis group more minor lesions disappeared in comparison to the medication group. On bicycle exercise tests, the time to 0.1 mV ST-segment depression increased significantly by 39% and the maximum level of ST depression decreased significantly by 0.07 mV in the apheresis group versus no changes in the medication group.Two years of lipid lowering both with medication alone or LDL-apheresis with medication showed angiographic arrest of the progression of coronary artery disease. However, more aggressive treatment induced functional improvement, which may precede anatomic changes.
Helminths can protect themselves against rejection inhibiting hostile respiratory allergy symptoms
Authors: E. Ç. Mingomataj, F. Xhixha, E. Gjata
Journal: Allergy (2006)

The ability of common environmental allergens to stimulate IgE responses and thus to produce allergic diseases has tended to overshadow the fact that helminthic parasites are possibly the most potent inducers of this immunoglobulin that exists in nature. Although it has been well established that during these infections there is a stimulation of IgE against their own antigens as well as a strong induction of nonspecific TH2/IL-4 polyclonal IgE, similarly to the allergic processes, many authors debate if the presence of these infections correlates inversely or not with the rate prevalence of atopy or respiratory allergy. Interpreting this relationship, we suggest that sometimes the intensive infections of hosts, especially with soil helminths which migrate in the respiratory ways or use there as entrance, can induce the production of some mediators ('helminth(k)ines'), to reduce the possibility of their reactive expulsion from the host. The ability to suppress hostile allergic symptoms despite the simultaneous induction of IgE response and local inflammation maybe is established due to the selective evolution, to assure for the parasites better chances for an effective life and reproduction within their mammalian hosts.
RNA Sequencing Analysis Identifies New Human Collagen Genes Involved in Cardiac Remodeling
Authors: Carolina Gil-Cayuela, Miguel Rivera, Ana Ortega, Estefanía Tarazón, Juan Carlos Triviño, Francisca Lago, José Ramón González-Juanatey, Luis Almenar, Luis Martínez-Dolz, Manuel Portolés
Journal: Journal of the American College of Cardiology (2015)
ELECTROENCEPHALOGRAPHIC STUDY OF CRIMINALS
Authors: FREDERIC A. GIBBS, B. K. BAGCHI, WILFRED BLOOMBERG
Journal: American Journal of Psychiatry (1945)

Electroencephalographic study of 452 criminals and 1,432 control subjects reveals that when age factors and sampling errors are controlled there are no significant differences between the two groups. Since the EEG is a fairly reliable indicator of epilepsy and organic brain disease, it seems reasonable to conclude that subclinical forms of these disorders are not contributing factors in a significant faction of the "sane" criminal population. No significant correlation could be found between the EEG and the type of criminal behavior.
Symptomatic Care of Patients With Amyotrophic Lateral Sclerosis
Authors: Alan M. Schindler
Journal: JAMA (1976)

<h3>To the Editor.—</h3> The article by Smith and Norris provides an interesting overview of the means available to alleviate the physical disability of ALS victims. Unfortunately, only passing attention was paid to the facts that "the patient is fully aware of the advancing disability and the future for himself and his family" and that "re active depression is common... it may result from fear of financial insecurity." Worse, the goal of "terminal care" seems to be that the patient might spend his "last days in dignity, free of worry about cost." And for the valient physician, now at the end of his "slings, canes, walkers, and wheelchairs... esophagostomies, tracheostomies... transtympanic neurectomies... cricopharyngeal myotomies": "a prescription of a strong narcotic may be a good physician's last positive contribution." This step is prescribed to relieve a "terrible mental anguish" brought about, one might suspect, as much by what was done
391 HCV core protein directly modulates hepatic fatty acid metabolism through enhancing carnitine palmitoyl transferase 1A activity to cause steatosis: relation to compensatory overexpression of rescue molecules, nuclear receptor PPARA and ABC transporter MDR3
Authors: A YAMAGUCHI, S TAZUMA, T NISHIOKA, H HYOGO, K TSUBOI, M SAKOMOTO, K KANNO, Y NUMATA, T KOBUKE, D KOMICHI
Journal: Hepatology (2003)
Disturbed Intracoronary Hemodynamics in Myocardial Bridging
Authors: Heinrich G. Klues, Ernst R. Schwarz, Jürgen vom Dahl, Thorsten Reffelmann, Helmut Reul, K. Potthast, C. Schmitz, Jürgen Minartz, Winfried Krebs, iPeter Hanrath
Journal: Circulation (1997)

The purpose of this study was to evaluate the hemodynamic mechanisms leading to myocardial ischemia in patients with myocardial bridging. Myocardial bridging is known to induce angina and even severe myocardial ischemia.In 12 symptomatic patients with myocardial bridges, quantitative coronary angiography was performed to obtain systolic/diastolic vessel diameters within the bridged segments. Coronary flow velocities, flow reserve, and pressures were determined with a 0.014-in Doppler and a 0.014-in pressure microtransducer. In 3 symptomatic patients, coronary stents were implanted and hemodynamic measurements were repeated immediately and after 7 weeks. An in vitro validation of the pressure measurements was performed. Angiography revealed a systolic diameter reduction of 80.6+/-9.2% and a persistent diastolic reduction of 35.3+/-11% within the bridged segment. Diastolic flow velocities (cm/s) were increased (31.5+/-14.3 within versus 17.3+/-5.7 proximal and 15.2+/-6.3 distal, P<.001). Coronary flow reserve distal to the bridge was 2.5+/-0.5. There was an increased peak systolic pressure within the bridged segment (171+/-48 versus 113+/-10 mm Hg proximal, P<.001). Stent placement abolished the phasic lumen compression, the diastolic flow abnormalities, the intracoronary peak systolic pressure, and clinical symptoms. Coronary flow reserve improved to 3.8+/-0.3.Coronary hemodynamics in myocardial bridges are characterized by a phasic systolic vessel compression with a localized peak pressure, persistent diastolic diameter reduction, increased blood flow velocities, retrograde flow, and a reduced flow reserve. These alterations may explain the occurrence of symptoms and ischemia in these patients. Intracoronary stent placement abolished all hemodynamic abnormalities and may improve clinical symptoms in otherwise unsuccessfully treated patients with myocardial bridges.
443 VITAMIN D DEFICIENCY IS FREQUENT IN CHRONIC HEPATITIS C AND AFFECTS THE OUTCOME OF INTERFERON-ALFA BASED THERAPY
Authors: C.M. Lange, J. Bojunga, E. Ramos-Lopez, M. von Wagner, J. Vermehren, E. Herrmann, K. Badenhoop, S. Zeuzem, C. Sarrazin
Journal: Journal of Hepatology (2011)
Appendectomies During Physicians' Boycott-Reply
Authors: Robert H. Pantell
Journal: JAMA (1980)

<h3>In Reply.—</h3> Drs Slee and James offer constructive comments on our study. By documenting a decrease in non emergency operations during and after the May 1975 boycott, Dr Slee has responded to our proposal that the degree to which surgery diminishes during a boycott may be a measure of the degree of electivity of the procedure. He also raised issues of whether this decrease may be accounted for by patient migration to other counties or by nonsurgical treatment. We attempted to address geographic migration by selecting San Francisco County, at the center of the six boycotting counties, and by analyzing patient residence throughout 1975. While there appeared to be no migration for appendicitis care, this may have occurred for elective surgery as well, though it seems unlikely. Nonsurgical treatment is another attractive hypothesis to explain the decrease in elective surgery. Further analysis would be necessary to determine whether patients or
Destiny Rides Again as Twins Overeat
Authors: Ethan A.H. Sims
Journal: New England Journal of Medicine (1990)

Does destiny indeed, as the Bard wrote, shape our ends (and middles)? In this issue of the Journal, Stunkard et al.1 and Macdonald and Stunkard2 have provided the most definitive answer to date to the question of whether childhood environment or genetic heritage is predominant in determining body-mass index in Western society. Similarly, Bouchard et al.3 at Laval University have concluded that destiny, in the form of our genetic makeup, has a great deal to do with the shape of our middles.Stunkard's group has drawn on the Swedish Adoption/Twin Study of Aging to evaluate the relation between body-mass . . .
Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil
Authors: Takeshi Aiba, Wataru Shimizu, Masashi Inagaki, Takashi Noda, Shunichiro Miyoshi, Wei-Guang Ding, Dimitar P. Zankov, Futoshi Toyoda, Hiroshi Matsuura, Minoru Horie, Kenji Sunagawa
Journal: Journal of the American College of Cardiology (2005)
The Relation of Trauma to Cardiac Disease
Authors: LOUIS A. LEVISON
Journal: Annals of Internal Medicine (1927)

Article1 October 1927The Relation of Trauma to Cardiac DiseaseLOUIS A. LEVISON, M.D.LOUIS A. LEVISON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-4-227 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe medico-legal phase of the problem whether indirect injury to the thorax can induce temporary or permanent damage to the myocardium is sufficiently important to justify the addition of one other case report of this type. The medical expert is frequently in grave doubt whether a myocardial involvement or a disturbance of rhythm should be ascribed to a previous injury or trauma. Included in this category is the matter of heat exhaustion or heat stroke as a factor in the production of permanent myocardial involvement with a disturbance of rhythm. The matter is of considerable interest to clinicians aside from...References(1) HAYJONES : The British Medical Journal, 3455: 559-562 (March 26), 1927. CrossrefGoogle Scholar(2) GOSSAGEHICKS : Quart. Journ. Med., 1913, p. 435. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Toledo, Ohio St. Vincent's Hospital PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCARDIAC INJURY DUE TO NONPENETRATING CHEST TRAUMA*JAMES H. WATSON, M.D., WARREN M. BARTHOLOMAE, M.D.HEART STRAIN: A CRITICAL REVIEW; THE DEVELOPMENT OF A PHYSIOLOGIC CONCEPT*AARON E. PARSONNET, M.D., C.M., F.A.C.P., ARTHUR BERNSTEIN, A.B., M.S., M.D.Nonpenetrating wounds of the heartTrauma To Viscera From Non-Penetrating External Injuries, With Special Reference To the Heart*E. L. TUOHY, B.A., M.D., F.A.C.P., P. G. BOMAN, B.A., M.D.Cardiovascular Lesions Following Injury to the Chest*MORRIS H. KAHN, M.A., M.D., SAMUEL KAHN, B.S., M.D. 1 October 1927Volume 1, Issue 4Page: 227-230KeywordsHeart diseasesMyocardial infarctionMyocardiumThorax Issue Published: 1 October 1927 PDF DownloadLoading ...