Hypertension Associated with Endothelin-Secreting Malignant Hemangioendothelioma
Authors: Koji Yokokawa, Hideki Tahara, Masakazu Kohno, Koh-ichi Murakawa, Kenichi Yasunari, Koichi Nakagawa, Toshio Hamada, Shuzo Otani, Masashi Yanagisawa, Tadanao Takeda
Journal: Annals of Internal Medicine (1991)

Brief Reports1 February 1991Hypertension Associated with Endothelin-Secreting Malignant HemangioendotheliomaKoji Yokokawa, MD, Hideki Tahara, MD, Masakazu Kohno, MD, Koh-ichi Murakawa, MD, Kenichi Yasunari, MD, Koichi Nakagawa, MD, Toshio Hamada, MD, Shuzo Otani, MD, Masashi Yanagisawa, MD, Tadanao Takeda, MDKoji Yokokawa, MD, Hideki Tahara, MD, Masakazu Kohno, MD, Koh-ichi Murakawa, MD, Kenichi Yasunari, MD, Koichi Nakagawa, MD, Toshio Hamada, MD, Shuzo Otani, MD, Masashi Yanagisawa, MD, Tadanao Takeda, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-3-213 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEndothelin-1, a potent vasoconstrictor peptide that has recently been isolated from the supernatant of cultured porcine aortic endothelial cells (1), is involved in some vascular disorders (2). Malignant hemangioendothelioma, a rare malignant vascular neoplasm, is characterized by intravascular proliferation of atypical endothelium. Patients with malignant hemangioendothelioma usually die with metastases to the lungs and brain or with vascular involvement in the brain or coronary arteries (3). We measured plasma levels of endothelin-1 in two patients with malignant hemangioendothelioma of the scalp before and after surgical excision.Materials and MethodsEndothelin-1 was extracted from EDTA-plasma or prepared tissue samples (4) through...References1. YanagisawaKuriharaKimura MHS. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:411-5. CrossrefMedlineGoogle Scholar2. MiyauchiYanagisawaTomizawa TMT. Increased plasma concentration of endothelin-1 and big endothelin-1 in acute myocardial infarction [Letter]. Lancet. 1989;2:53-4. CrossrefMedlineGoogle Scholar3. PetitoGottliebDoughertyPetito CGJF. Neoplasmic angioendotheliosis: ultrastructural study and review of the literature. Ann Neurol. 1978;3:393-9. CrossrefMedlineGoogle Scholar4. NakaoSugawaraMorii KAN. Radioimmunoassay for α-human and rat atrial natriuretic polypeptide. Biochem Biophys Res Commun. 1984;124:815-21. CrossrefMedlineGoogle Scholar5. KohnoMurakawaYasunari MKK. Prolonged blood pressure elevation after endothelin administration in bilaterally nephrectomized rats. Metabolism. 1989;38:712-3. CrossrefMedlineGoogle Scholar6. KohnoYasunariMurakawa MKM. Plasma immunoreactive endothelin in essential hypertension. Am J Med. 1990;88:614-8. CrossrefMedlineGoogle Scholar7. ChomczynskiSacchi PN. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-9. CrossrefMedlineGoogle Scholar8. VierhapperWagnerNowotnyWaldhausl HOPW. Effect of endothelin-1 in man. Circulation. 1990;81:1415-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From Osaka City University Medical School, Osaka, Japan; and the Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan. For current author addresses, see end of text. 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Implications for vascular function.Biological actions and pathophysiologic significance of endothelin in the kidneyEndothelin-dependent hypertensionEndothelin 1 February 1991Volume 114, Issue 3Page: 213-215KeywordsBiochemistryBlood plasmaBrainCoronary arteriesDermatologyEndothelial cellsEndotheliumHypertensionLungsPharmacology Issue Published: 1 February 1991 PDF downloadLoading ...