Agranulocytosis Induced by Nonchemotherapy Drugs
Authors: Frank Andersohn, Christine Konzen, Edeltraut Garbe
Journal: Annals of Internal Medicine (2008)

Letters19 February 2008Agranulocytosis Induced by Nonchemotherapy DrugsFrank Andersohn, MD, Christine Konzen, MD, and Edeltraut Garbe, MD, PhDFrank Andersohn, MDFrom Bremen Institute for Prevention Research and Social Medicine, 28539 Bremen, Germany, and Charité—Universitaetsmedizin Berlin, 10117 Berlin, Germany.Search for more papers by this author, Christine Konzen, MDFrom Bremen Institute for Prevention Research and Social Medicine, 28539 Bremen, Germany, and Charité—Universitaetsmedizin Berlin, 10117 Berlin, Germany.Search for more papers by this author, and Edeltraut Garbe, MD, PhDFrom Bremen Institute for Prevention Research and Social Medicine, 28539 Bremen, Germany, and Charité—Universitaetsmedizin Berlin, 10117 Berlin, Germany.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-4-200802190-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Most of the case reports suggested by Dr. Salem and colleagues were already included in our review (n = 10) (1). Six of the suggested reports were excluded because of use of cytotoxic drugs, pancytopenia, or a neutrophil count nadir of 0.5 × 109 cells/L or greater. Only 2 of the listed case reports (on carbutamide and nifedipine) were not identified because they were not listed as case reports in the MEDLINE publication type field. As causality is “possible” in these reports, the inclusion of these cases during the next database update will not cause any change in our Table 2. ...References1. Andersohn F, Konzen C, Garbe E. List of case reports of non-chemotherapy drug-induced agranulocytosis. 2007. Accessed at www.adverse-effects.com/documents/case_reports_agranulocytosis.pdf on 14 June 2007. Google Scholar2. Benichou C, Solal Celigny P. Standardization of definitions and criteria for causality assessment of adverse drug reactions. Drug-induced blood cytopenias: report of an international consensus meeting. Nouv Rev Fr Hematol. 1991;33:257-62. [PMID: 1956763] MedlineGoogle Scholar3. van der Klauw MM, Goudsmit R, Halie MR, van't Veer MB, Herings RM, Wilson JH, et al. A population-based case-cohort study of drug-associated agranulocytosis. Arch Intern Med. 1999;159:369-74. [PMID: 10030310] CrossrefMedlineGoogle Scholar4. Summary of product characteristics: ben-u-ron 500 mg Tabletten. Munich, Germany: bene Arzneimittel GmbH; 2007. Google Scholar Author, Article, and Disclosure InformationAuthors: Frank Andersohn, MD; Christine Konzen, MD; Edeltraut Garbe, MD, PhDAffiliations: From Bremen Institute for Prevention Research and Social Medicine, 28539 Bremen, Germany, and Charité—Universitaetsmedizin Berlin, 10117 Berlin, Germany.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSystematic Review: Agranulocytosis Induced by Nonchemotherapy Drugs Frank Andersohn , Christine Konzen , and Edeltraut Garbe Agranulocytosis Induced by Nonchemotherapy Drugs Chaker Ben Salem , Raoudha Slim , Houssem Hmouda , and Kamel Bouraoui Agranulocytosis Induced by Nonchemotherapy Drugs Luisa Ibáñez , Xavier Vidal , and Joan-Ramon Laporte Agranulocytosis Induced by Nonchemotherapy Drugs Sherif B. Mossad Agranulocytosis Induced by Nonchemotherapy Drugs Sridhar Mani Metrics 19 February 2008Volume 148, Issue 4 Page: 320-321 Keywords Bone marrow Databases Drugs Granulocyte colony stimulating factor Granulocytes Macrophages Methotrexate Neutropenia Neutrophils Risk management ePublished: 19 February 2008 Issue Published: 19 February 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...