tbuckley/cabot-search huggingface dataset:
Immunoblotting as a confirmatory test for antimitochondrial antibodies in primary biliary cirrhosis.
Authors: G Provenzano, O Diquattro, A Craxi, P Almasio, G Pinzello, L Marino, G Fiorentino, F Rinaldi, L Pagliaro
Journal: Gut (1993)

Primary biliary cirrhosis is characterised by the presence of antimitochondrial antibodies which are directed against components of mitochondrial dehydrogenase complexes. The specificity of antimitochondrial antibodies for primary biliary cirrhosis as detected by immunoblotting was investigated. Commercially available preparations of pyruvate and oxo-glutarate dehydrogenases and beef-heart mitochondria were used as source of antigens. Sera from 47 primary biliary cirrhosis patients (46 of whom were antimitochondrial antibody positive by immunofluorescence), 16 non-primary biliary cirrhosis patients (antimitochondrial antibody positive by immunofluorescence), 23 liver-kidney microsomal antibody positive chronic active hepatitis patients, and 32 patients with connective tissue diseases were examined. Of the 47 subjects with primary biliary cirrhosis, 43 (91%) and 13 (28%) tested positive by immunoblotting for pyruvate and oxo-glutarate dehydrogenase, respectively. Only three primary biliary cirrhosis patients were negative for both antigens, including the only one shown to be antimitochondrial antibody negative by immunofluorescence. The other two patients were positive by immunoblotting with beef-heart mitochondria. In contrast, only three of 16 (19%) non-primary biliary cirrhosis patients who were antimitochondrial antibody positive by immunofluorescence tested positive by immunoblotting (for both pyruvate dehydrogenase and beef-heart mitochondria). None of the 23 liver-kidney microsomal antibody positive and the 32 patients with rheumatic diseases were positive by immunoblotting with any antigen. Our data show that immunoblotting with commercially available oxo-acid dehydrogenases is a reproducible method for the detection of antimitochondrial antibodies highly specific for primary biliary cirrhosis.
CHOLERA AND INFECTED WATERS.
Authors: CHARLES E. WOODRUFF
Journal: JAMA (1905)

The experience gained by the American military surgeons during the Philippine cholera epidemic of 1902 and 1903 has enabled them to correct a few errors in the current theories as to the methods of the spread of this dreadfully fatal disease. From their knowledge of the biologic characters of the spirillum, they were forced into an investigation, first, of the manner in which the living germ was transported into uninfected territory, and, second, of the manner in which it was carried from patient to patient after it was planted in this new territory. The spirillum is a very frail organism, which leads practically a parasitic existence, for it soon perishes outside of the host. Experimentally, it has been determined that it is killed in five minutes by a temperature of 80 C., in two hours by drying, and more quickly still if dried in the sunlight. Hence, as an invariable
The Human Brain
Authors: John B. Selhorst
Journal: JAMA (1989)

Dr Glees, a neuroanatomist with a lifelong interest in functional morphology, has written this text to draw attention to significant developments in the neurosciences during the past 20 years. It is more, however, for<i>The Human Brain</i>is a comprehensive synopsis of what Dr Glees has learned during his career as a teacher and researcher studying the structure and function of the developing adult brain. The human fetus, with its prominent head, is featured on the cover. Within, the phylogenetic evolution of the central nervous system is concisely stated, beginning with hydras and extending through vertebrates to the enormous development of the forebrain in man. A discussion of the fine and macrostructure of the cellular components of the nervous system follows. Functional relevance is maintained through neurophysiological explanations of synaptic transmission and action potential propagation. The section on cerebral blood vessels and cerebrospinal fluid is sprinkled with physiological data such
Systolic Time Intervals During Epinephrine Infusions in Normals and Idiopathic Hypertrophic Subaortic Stenosis (IHSS).
Authors: Stephen H. Salzman
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Systolic Time Intervals During Epinephrine Infusions in Normals and Idiopathic Hypertrophic Subaortic Stenosis (IHSS).Stephen H. Salzman, M.D., Steven Wolfson, M.D., Bruce Jackson, M.D., Eliot Schechter, M.D.Stephen H. Salzman, M.D.Search for more papers by this author, Steven Wolfson, M.D.Search for more papers by this author, Bruce Jackson, M.D.Search for more papers by this author, Eliot Schechter, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-783_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this study was to standardize a simple clinical test to assess left ventricular response to the neurohumoral mediator of the sympathetic nervous system, epinephrine. Its clinical usefulness was tested by applying it in patients with idiopathic hypertrophic subaortic stenosis. Weissler's systolic time intervals were recorded at epinephrine infusion rates of 0.01 through 0.18 µg/kg/min in 14 normal subjects and 9 patients with idiopathic hypertrophic subaortic stenosis. The infusion sequence was repeated after beta blockade with propranolol, 0.1 µg/kg in the idiopathic hypertrophic subaortic stenosis patients. Results are expressed for preejection period in milliseconds and for left ventricular... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Stephen H. Salzman, M.D.; Steven Wolfson, M.D.; Bruce Jackson, M.D.; Eliot Schechter, M.D.Affiliations: Lackland Air Force Base, Tex. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPhysiologic responses to epinephrine infusion: The basis for a new stress test for coronary artery disease 1 May 1970Volume 72, Issue 5Page: 783-783KeywordsEpinephrineStenosisSympathetic nervous systemSystole ePublished: 1 December 2008 Issue Published: 1 May 1970 PDF downloadLoading ...
Naloxone Treatment of Opiate Dependence
Authors: Arthur Zaks
Journal: JAMA (1971)

The duration of action of naloxone hydrochloride, a narcotic antagonist, was extended by increasing doses in nine male volunteers. Blockade against intravenously administered heroin challenges was measured. A daily dose of 2.4 gm of naloxone hydrochloride elicited blockade to 25 mg of heroin and 3.0 gm extended blockade to 50 mg of heroin both for 24 hours. No toxic symptoms occurred in nine weeks of naloxone administration. In order to use antagonists in the prophylaxis of opiate dependence, a long-acting, parenterally administered formulation must be developed.
PTH-128 The Frax Algorithm is of Limited Utility in Predicting Osteoporosis in Coeliac Disease: Abstract PTH-128 Table 1
Authors: A Mattinson, B Hauser, H Gillett, P Gillett, C Goddard, N Kennedy, A Shand, S Ralston, J Satsangi, P Riches
Journal: Gut (2013)

<h3>Introduction</h3> Osteoporosis is the commonest complication of coeliac disease yet no reliable scoring system exists to guide patient selection for bone density measurement. The FRAX tool has been developed by the World Health Organisation to estimate fracture risk based on clinical factors and incorporates causes of secondary osteoporosis such as coeliac disease (1). We have analysed the utility of FRAX in identifying osteoporosis in a cohort of patients with coeliac disease. <h3>Methods</h3> 170 patients were recruited from coeliac clinics between October 2011 and 2012. 17 patients in whom bone mineral density results were not available were excluded, yielding a final study population of 153. Information on clinical risk factors for osteoporosis were collected by questionnaire. Two-tailed independent student t-tests, Mann Whitney U test or Chi-square tests were applied as appropriate. Statistical analysis was performed on SPSS. <h3>Results</h3> The prevalence of osteoporosis in our cohort was 15% (23/153). The distribution of risk factors used in the FRAX algorithm are shown in table 1. Factors significantly associated with osteoporosis in our cohort included increasing age, reduced height, weight and history of glucocorticoid use. The median 10 year risk of major osteoporotic fracture was 6.7% (interquartile range 8.5). A ROC analysis of FRAX as a predictor of osteoporosis yielded an area under the curve of just 0.614. <h3>Conclusion</h3> The FRAX algorithm is not a reliable predictor of osteoporosis. A screening threshold of &gt; 10% 10 year risk of major fracture gives a sensitivity of 43% and specificity of 73% for detection of osteoporosis. A lower threshold of 5% 10 year risk only increases sensitivity to 78% at a cost to specificity of 59%. Further work in constructing specific risk predictors for osteoporosis in coeliac disease is required. <h3>Disclosure of Interest</h3> None Declared. <h3>Reference</h3> Kanis JA<i> et al.</i> (2008) FRA<sup>XT</sup>M and the assessment of fracture probability in men and women from the UK. Osteoporosis International 19: 385–397.
Integrated Medical Groups and Higher-Quality Medical Care
Authors: P. Dileep Kumar
Journal: Annals of Internal Medicine (2007)

Letters17 July 2007Integrated Medical Groups and Higher-Quality Medical CareP. Dileep Kumar, MDP. Dileep Kumar, MDFrom Port Huron Hospital, Port Huron, MI 48060.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-2-200707170-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Mehrotra and colleagues' article (1) on the quality of care provided by integrated medical groups and individual practice associations is flawed because the authors base their conclusions on claims data. It is well known that assuming quality standards from the data that physicians submit for billing purposes is less than perfect. Moreover, the paper implies that solo practitioners and small practices fare poorly in quality measures because they are systematically different. This is not an encouraging comment about the hundreds of practicing primary care physicians, a large majority of them internists.The paper also dwells extensively on ...Reference1. Mehrotra A, Epstein AM, Rosenthal MB. Do integrated medical groups provide higher-quality medical care than individual practice associations? Ann Intern Med. 2006;145:826-33. [PMID: 17146067] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: P. Dileep Kumar, MDAffiliations: From Port Huron Hospital, Port Huron, MI 48060.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDo Integrated Medical Groups Provide Higher-Quality Medical Care than Individual Practice Associations? Ateev Mehrotra , Arnold M. Epstein , and Meredith B. Rosenthal Integrated Medical Groups and Higher-Quality Medical Care Ateev Mehrotra , Arnold M. Epstein , and Meredith B. Rosenthal Metrics Cited byHIV rapid testing in the framework of an STI prevention project on a cohort of vulnerable Italians and immigrants 17 July 2007Volume 147, Issue 2Page: 147KeywordsComputing systemsConflicts of interestElectronic medical recordsHealth care qualityPrimary care physiciansSystemic diseases ePublished: 17 July 2007 Issue Published: 17 July 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice
Authors: Marta Paterlini, Stanislav S Zakharenko, Wen-Sung Lai, Jie Qin, Hui Zhang, Jun Mukai, Koen G C Westphal, Berend Olivier, David Sulzer, Paul Pavlidis, Steven A Siegelbaum, Maria Karayiorgou, Joseph A Gogos
Journal: Nature Neuroscience (2005)
Total paracentesis with dextran 40 vs diuretics in the treatment of ascites in cirrhosis: a randomized controlled study
Authors: Ricard Solà, Maria Carme Vila, Montserrat Andreu, Maria Isabel Oliver, Susanna Coll, Jordi Gana, Sergio Ledesma, Pere Ginès, Wladimiro Jiménez, Vicente Arroyo
Journal: Journal of Hepatology (1994)
An Independent Evaluation of the Lens Opacities Classification system II (LOCS II)
Authors: Giovanni Maraini, Paolo Pasquini, Maria C. Tomba, Mirka Bonacini, Maria A. Stazi, Francesco Rosmini, Robert D. Sperduto, G. Maraini, P. Pasquini, G. Maraini, M. Bonacini, R. Cantarelli, S. Preti, C. Tencani, M.C. Tomba, S.L. Williams, P. Pasquini, R.M. Corona, F. Rosmini, M.A. Stazi, R. Raschetti, G.L. Rossi, G. Damiani, M. Meazza, S. Volta, A. Bolchi, R.D. Sperduto, R.L. Mowery, M.C. Leske, H. Kahn
Journal: Ophthalmology (1989)
Study of the Mechanisms of Biliary Stent Occlusion: an Analysis of Occluded and Nonoccluded Stents, with Emphasis on the Role of Antinucleating Biliary Anionic Peptide Factor
Authors: F. Prat, C. Cosson, N. Domingo, O. Chapat, D. Fompeydie, N. Nassar, J. Fritsch, A. D. Choury, G. Pelletier, C. Buffet
Journal: Endoscopy (2004)

Background and Study Aims: Plastic stents tend to become occluded by sludge deposition, and the mechanisms underlying the process are still partly unclear. In the present study, occluded and nonoccluded stents were examined in order to clarify the role of proteins (with emphasis on the 7-kDa biliary antinucleating anionic peptide factor, APF), microorganisms, and minerals. Patients and Methods: In a prospective study comparing stents exchanged prophylactically or in case of dysfunction, 58 polyethylene stents were collected and analyzed. The stents were classified macroscopically as either nonoccluded or occluded. Infrared spectroscopy of the stent contents, 15 % sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), immunological detection and quantification of APF, electron-microscopic scanning, and bacteriological analysis were carried out. Results: Thirty-eight stents were occluded and 20 were patent. The composition of the stent biofilms identified on spectrophotometry differed significantly between occluded and nonoccluded stents (P < 0.01). The main constituent of the biofilm in the occluded stents was calcium bilirubinate and palmitate, but in the nonoccluded stents the main constituent was proteins. The protein spectra did not differ between the two groups. In both groups, the majority of bacterial strains were not positive for β-glucuronidase. APF contributed to the protein biofilm in all of the stents to a small extent. A significant decrease (- 11.8 %; P < 0.05) in APF was observed in the occluded stents, as evidenced by electrophoresis, immunoblotting, and enzyme-linked immunoassay. Conclusions: Obstruction is initiated by the deposition of a protein biofilm on the inner stent wall; reduced APF levels may play a significant role in this process. Future trials of prophylactic treatment against stent obstruction should be aimed at preventing protein deposition and at modifying the overall balance of protein constituents.
Extractable Collagen of Normal and Lathyrus-Fed Rats
Authors: Zolton T. Wirtschafter, J. Peter Bentley
Journal: JAMA (1963)

LATHYRISM is a pathological process still very j frequently seen in humans during periods of famine and extreme poverty, as in wartime and as in under-privileged countries. It is produced by eating the peas of the<i>Lathyrus odoratus</i>, the sweet-pea plant. In the laboratory, it is produced either by the administration of the pea-pellet diet, or amino-nitriles, the toxic agent of the sweet-pea. As we will see, the degree of severity is related to the age of the experimental animal. The result obtained in our laboratory was that no rat embryo was able to survive in the presence of the<i>Lathyrus</i>factor beyond the 16th day.<sup>1</sup>In contrast, the adult female exposed quantitatively to the same lathyrogenic factor demonstrates during gestation no osseous or other lesions characteristic of lathyrism. Only when fed the<i>Lathyrus</i>factor for a much longer time than the gestation period, for example 6 weeks,
Age, ethnicity, and mental illness: a triple whammy
Authors: G. Rait, A. Burns, C. Chew
Journal: BMJ (1996)

A major public health issue for the next century is the increase in the number of elderly people from ethnic minority groups. The large numbers in the 40–64 year old cohort will soon be in the over 65 group, which is traditionally associated with particular health, social, and economic needs.1 2 3 Attention has tended to be focused on the physical health of these groups,4 and this, together with the traditional stigma of mental illness, has led to relative neglect of the mental health of older people from ethnic minorities.

Up to 15% of elderly people are known to suffer from depressive symptoms, of whom …
Fundamentals of Hyperbaric Medicine
Authors: Sanford A. Franzblau
Journal: JAMA (1966)

Niggles and inkles are becoming increasingly important. You should know about them because they may be premonitory symptoms auguring the onset of the staggers, the chokes, or the bends. You won't find these terms in a medical dictionary—as yet, but they are part of the new terminology of a resurging medical field, born in the light of modern physiology. The National Academy of Sciences, recognizing that the recent wave of interest in hyperbaric oxygenation could result in many hastily conceived ventures fraught with danger to both patients and researchers, in 1963 issued a paper on the potentialities and problems in this field. It has now followed through with an authoritative manual. The authorship comes from the best minds in this field, from men who have made hyperbaric medicine their life's work. As Dr. Seeley of the National Research Council staff has indicated, in this book the clinician will not find
Postoperative Wound Infection
Authors: Ronald Lee Nichols
Journal: New England Journal of Medicine (1982)

Postoperative infectious complications are a frequent cause of morbidity and mortality in the surgical patient. These septic events usually involve the urinary or respiratory tracts or occur in the operative wound. The overall incidence of postoperative wound infection was 7.5 per cent in a much-quoted national study reported nearly two decades ago.1 The incidence varied from surgeon to surgeon, from hospital to hospital, and from one surgical procedure to another. The lowest infection rate (<2 per cent) followed clean operations, such as elective orthopedic procedures or herniorrhaphy, in which the possible sources of wound contamination were solely airborne or exogenous. . . .
The Health Care of Hispanics
Authors: Aaron Manson
Journal: JAMA (1991)

<h3>To the Editor. —</h3> In one of the editorials of the January 9, 1991, issue, Drs Furino and Muñoz<sup>1</sup>state that "there are many hypotheses but little consensus" as to whether increasing the number of Hispanic physicians will improve health care access and utilization for Spanish-speaking patients. We studied the effect of a language barrier on health care utilization by Hispanic patients.<sup>2</sup>We found that, compared with monolingual Spanish-speaking patients with bilingual physicians (language concordant patients), monolingual Spanish-speaking patients with monolingual English-speaking physicians (language discordant patients) were three times more likely to omit medications, three times more likely to miss office appointments, and twice as likely to make emergency department visits. All but one of the bilingual physicians were Hispanic. Moreover, we surveyed 43 university hospitals in the United States and found that over half had no bilingual physicians on staff. The dimensions of this problem are suggested
A Case of Poisoning with Liquor Morphinae Hydrochloridi: Recovery
Authors: H. C. Colman
Journal: BMJ (1899)

POISONING WITH MORPHINE HYDROCHLORIDE.LW 17.3 during the day, still helping himself with two chairs.Ordinary sticks did not afford sufficiently firm basis to support him, so I had two straight sticks constructed, with a basis to each like a emall plate.On May 5th, 1899, he was walking about the ward by the help of one of his sticks and a chair.CONDITION OF PATIENT MAY 20TH, I899.Lejt Side.Hip-joint.-There is fair power of flexion of hip-joint and possibly a very slight power of extenslon, but the latter doubtful.Knee-joint.-There is fair power of extension of left knee-joint, so that the leg can be held straight out In the air.There is no power whatever to flex the left knee-joint.An appearance of this movement is Produced by flexing the hip-joint when the leg at the knee-joint naturally bends owing to gravity, but if the femur be fxed no flexion at knee-joint can be produced.Ankle.-No movement whatever at ankle-joint, foot in position of moderate " varus."Right Side.Hip-joint.-There is slight power of flexion of hip-joint present, but less thau on left side.There seems to be very slight power of extension, but this is doubtful.knee-joint.-Nomovement.Ankle.-No movement.Anmesthesia.-Totalanmsthesia on right side up to groin, on left side up to ievel of about I inches above knee-joint.
Potential Improvements in Means of Evaluation of Acute Myocardial Infarction
Authors: Charles K. Friedberg, W. Proctor Harvey, NORA GOLDSCHLAGER, KURT RAVENS, GEORG LEB, CHARLES COWAN, RICHARD J. BING
Journal: Circulation (1969)

Effective capillary blood flow (ECF) through the myocardium was studied after experimentally produced myocardial infarction in 33 dogs, and after clinical acute myocardial infarction in nine human subjects. In dogs, ECF as measured by Rubidium-86, was compared to terminal vascular capacity (TVC) as measured by I-131 albumin in infarcted and noninfarcted portions of the myocardium. In man, ECF was determined from the myocardial uptake of Rubidium-84 by the double coincidence counting system. A discrepancy between ECF and TVC in animals became apparent by the tenth day after infarction, at which time TVC had attained control levels, whereas ECF had not; 2 months later, ECF was still 24% less than control. Studies in man demonstrated a significant decrease in ECF within 4 days of infarction; the low flow persisted in one patient 6 weeks after the initial injury. Low ECF in patients was present despite the insignificant changes in cardiac and stroke indices, and in mean aortic pressure. It is thought that the low values for ECF after acute myocardial infarction might reflect alterations in cellular metabolism leading to interference with tissue uptake of rubidium. The discussion that followed this paper appears after the paper by Dr. Richard Gorlin.
Global research for health
Authors: M. McKee
Journal: BMJ (2008)

Should tackle health needs and inform policyLast week delegations from 59 governments, international agencies, and researchers met in Bamako, Mali, to discuss the state of global health research.It was an opportunity to review progress since their last meeting, four years earlier, in Mexico City, and to set an agenda for the future.1The meeting in Mexico is widely seen as a turning point, where the importance of research tackling the greatest health needs was emphasised, and where a strategy for meeting these needs was proposed.Arguably, in a world with scarce resources efforts should be focused on where they can do most good.To make this happen, those attending the conference in Mexico advocated greater investment in research on health systems and policy, the development of national health research policies, and the incorporation of evidence into health policy.