tbuckley/cabot-search huggingface dataset:
Colchicine inhibits pressure-induced tumor cell implantation within surgical wounds and enhances tumor-free survival in mice
Authors: David H. Craig, Cheri R. Owen, William C. Conway, Mary F. Walsh, Christina Downey, Marc D. Basson
Journal: Journal of Clinical Investigation (2008)

Iatrogenic tumor cell implantation within surgical wounds can compromise curative cancer surgery. Adhesion of cancer cells, in particular colon cancer cells, is stimulated by exposure to increased extracellular pressure through a cytoskeleton-dependent signaling mechanism requiring FAK, Src, Akt, and paxillin. Mechanical stimuli during tumor resection may therefore negatively impact patient outcome. We hypothesized that perioperative administration of colchicine, which prevents microtubule polymerization, could disrupt pressure-stimulated tumor cell adhesion to surgical wounds and enhance tumor-free survival. Ex vivo treatment of Co26 and Co51 colon cancer cells with colchicine inhibited pressure-stimulated cell adhesion to murine surgical wounds and blocked pressure-induced FAK and Akt phosphorylation. Surgical wound contamination with pressure-activated Co26 and Co51 cells significantly reduced tumor-free survival compared with contamination with tumor cells under ambient pressure. Mice treated with pressure-activated Co26 and Co51 cells from tumors preoperatively treated with colchicine in vivo displayed reduced surgical site implantation and significantly increased tumor-free survival compared with mice exposed to pressure-activated cells from tumors not pretreated with colchicine. Our data suggest that pressure activation of malignant cells promotes tumor development and impairs tumor-free survival and that perioperative colchicine administration or similar interventions may inhibit this effect.
Hazards of Laparoscopy
Authors: A. D. R. Ogborn, M. P. Milligan, A. D. Noble
Journal: BMJ (1973)

In this letter a report is made of a severe retroperitoneal hematoma which occurred during laparoscopy for tubal ligation and necessitated a laparatomy.  The hematoma was caused by a small perforation of the peritoneum of the posterior abdominal wall.  The Verres needle was inserted just below the umbilicus on the second attempt.  It is now the opinion of the authors that the safest site for introduction of the Verres needle is halfway between the symphysis pubis and the umbilicus with the patient in the lithotomy position and resting anteriorly at a 3-degree tilt.
Early MRI measures independently predict 1-year and 2-year radiographic progression in rheumatoid arthritis: secondary analysis from a large clinical trial
Authors: Joshua F Baker, Mikkel Østergaard, Paul Emery, Elizabeth C Hsia, Jiandong Lu, Daniel G Baker, Philip G Conaghan
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objective</h3> To determine if early MRI measures predict X-ray progression at 1 and 2 years in a large RA trial cohort. <h3>Design</h3> This study included 256 methotrexate (MTX)-naïve RA patients from a randomised placebo-controlled trial of golimumab (GO-BEFORE). MRIs of wrist and 2nd–5th metacarpophalangeal joints at 0, 12, 24, 52 and 104 weeks were obtained and scored using the RAMRIS system. Multivariable logistic regression examined if baseline and early change (weeks 12/24) in RAMRIS scores independently predicted progression of the van der Heijde-Sharp (vdHS) score and MRI erosion score at 1 and 2 years of follow-up. <h3>Results</h3> High baseline score and poor improvement over the first 24 weeks in synovitis (p=0.003 and p=0.003, respectively) and in bone oedema (p=0.02 and p=0.001, respectively) were independent predictors of X-ray progression at 1 year. Associations were significant or tended towards an association at 2 years. An increase in RAMRIS bone erosion &gt;0.5 at weeks 12 and 24 also predicted X-ray progression (p&lt;0.003). Poor 12-week improvement in bone oedema was associated with X-ray and MRI progression at 1 year (p&lt;0.05). Regression models that incorporated baseline and 12-week and 24-week changes in MRI measures of synovitis (AUC=0.71) and bone oedema (AUC=0.70) improved the prediction of X-ray progression at 1 year above clinical disease activity alone (AUC=0.66, p&lt;0.04). <h3>Conclusions</h3> Baseline and early changes in MRI measures independently predicted X-ray and MRI progression at later time-points. The predictive validity established here supports potential use in shorter-duration studies to determine efficacy of RA therapies in preventing structural damage.
TIME-DEPENDENCY PREDICTORS AND IMPACT ON OUTCOME OF INFARCT TRANSMURALITY ASSESSED BY MAGNETIC RESONANCE IMAGING IN PATIENTS WITH ST-ELEVATION MYOCARDIAL INFARCTION REPERFUSED BY PRIMARY PERCUTANEOUS INTERVENTION
Authors: Suzanne De Waha, Steffen Desch, Ingo Eitel, Georg Fuernau, Philipp Lurz, Matthias Grothoff, Matthias Gutberlet, Gerhard Schuler, Holger Thiele
Journal: Journal of the American College of Cardiology (2011)
Enteral Hyperalimentation: An Alternative to Central Venous Hyperalimentation
Authors: STEVEN B. HEYMSFIELD
Journal: Annals of Internal Medicine (1979)

Severe protein-energy undernutrition is a frequent finding among chronically ill patients. Its causes are anorexia, hypermetabolism, and malabsorption. Adverse consequences include impaired cell-mediated immunity, increased susceptibility to infection, poor wound healing, weakness, and death. Spontaneous oral intake is inadequate in patients with this disorder, and therapeutic maintenance or repletion alimentation is needed. Enteral hyperalimentation is the method of choice, if tolerated. A successful treatment program usually requires a small-bore, flexible nasoenteral tube, appropriate feeding solution, and constant flow delivery of nutrient. If only partial dietary requirements are tolerated enterally, peripheral intravenous nutrient solutions can often supply the deficit. Although not suitable for all patients, enteral hyperalimentation is more physiologic, safer, easier, and more economical than central venous hyperalimentation. It would be well tolerated by many patients who now receive nutritional repletion by the latter method.
Culture of Mycobacterium kansasii in the blood of an HIV negative patient.
Authors: D Veale, D Fishwick, J E White, A D Gascoigne, K Gould, P A Corris
Journal: Thorax (1993)

A 23 year old man with a congenital myelodysplastic disorder and fibrosing lung disease received treatment with prednisolone. After nine months his condition deteriorated and Mycobacterium kansasii was isolated from blood cultures and lymph node biopsy specimens. He responded to antituberculous treatment. M kansasii has not previously been isolated from the blood stream of HIV negative patients.
The Comparison of the Treatment Strategies Preferred in Patients with ST Segment Elevated Myocardial Infarction (Thrombolytic Therapy for Life)
Authors: Mahmut Özdemir, Mustafa Yurtdaş, Musa Şahin, Nesim Aladağ, Sevdegül Karadaş, Naci Babat, Hasan Ali Gümrükçüoğlu
Journal: Journal of the American College of Cardiology (2013)
Access Affects Screening
Authors: Mike Mitka
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Computation of derived diagnostic quantities during intermittent coronary sinus occlusion in dogs
Authors: W SCHREINER, F NEUMANN, J SCHUSTER, K C FROEHLICH, W MOHL
Journal: Cardiovascular Research (1988)

Journal Article Computation of derived diagnostic quantities during intermittent coronary sinus occlusion in dogs Get access W SCHREINER, W SCHREINER From the Second Surgical University Clinic of Vienna, Vienna, Austria Search for other works by this author on: Oxford Academic PubMed Google Scholar F NEUMANN, F NEUMANN From the Second Surgical University Clinic of Vienna, Vienna, Austria Search for other works by this author on: Oxford Academic PubMed Google Scholar J SCHUSTER, J SCHUSTER From the Second Surgical University Clinic of Vienna, Vienna, Austria Search for other works by this author on: Oxford Academic PubMed Google Scholar K C FROEHLICH, K C FROEHLICH From the Second Surgical University Clinic of Vienna, Vienna, Austria Search for other works by this author on: Oxford Academic PubMed Google Scholar W MOHL W MOHL From the Second Surgical University Clinic of Vienna, Vienna, Austria Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 22, Issue 4, April 1988, Pages 265–276, https://doi.org/10.1093/cvr/22.4.265 Published: 01 April 1988 Article history Received: 01 July 1987 Accepted: 02 December 1987 Published: 01 April 1988
Obstructive Sleep Apnea and Age
Authors: Liat Ayalon, Sonia Ancoli-Israel, Sean P. A. Drummond
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Healthy aging is associated with cognitive deficits similar to those found in obstructive sleep apnea (OSA). As in OSA, older adults show compensatory cerebral activation during cognitive demands in the face of neurocognitive decline.The current study examines whether the combination of increasing age and sleep apnea will lead to a stronger compensatory response than either factor alone, or overwhelm the brain's capacity to compensate.A total of 14 treatment-naive patients with sleep apnea (aged 25-59 yr) and 14 age-matched healthy control subjects were each divided into two age groups of young (<45 yr) and middle-aged (> or = 45 yr). All underwent a sleep study, followed the next morning by a functional magnetic resonance imaging session that included a sustained attention and a verbal encoding task. A priori contrast analyses compared middle-aged patients with OSA to young patients, young control subjects, and middle-aged control subjects.Middle-aged patients with OSA showed reduced performance for immediate word recall and slower reaction time during sustained attention compared with the other three groups (middle-aged control, young sleep apnea, and young control). For both tasks, decreased activation was detected for middle-aged sleep apnea relative to the other groups in task-related brain regions.These results suggest that the presence of both sleep apnea and increasing age overwhelmed the brain's capacity to respond to cognitive challenges with compensatory recruitment and to maintain performance. The findings that sleep apnea impairs performance and brain function at a younger age than what might ordinarily be expected underscore the importance of early diagnosis and treatment of sleep apnea.
Acquired chronic candidiasis treated with transfer factor
Authors: C. C. BENZ, J. W. THOMAS, M. MANDL, NORMA MORGAN
Journal: British Journal of Dermatology (1977)

A patient with acquired chronic oral and vaginal candidiasis resistant to topical and parenteral therapy was found to have impaired cell mediated immunity to Candida antigen and loss of skin test response to tuberculin (Mantoux). Treatment with Candida-active transfer factor produced clinical remission lasting 1 year and restitution of in vitro and in vivo immune parameters. Relapse occurred while receiving a second lot of transfer factor from the same donor. Subsequent treatment with levamisole was associated with onset of agranulocytosis.
433 A prospective open study of long-term lamivudine treatment in children with chronic hepatitis B unresponsive to previous interferon alpha therapy
Authors: D.M. Lebensztejn, E. Skiba, O. Kovalchuk, M.E. Sobaniec-Lotowska, M. Kaczmarski, L. Chyczewski
Journal: Journal of Hepatology (2004)
Toward almost closed genomes with GapFiller
Authors: Marten Boetzer, Walter Pirovano
Journal: Genome biology (2012)

De novo assembly is a commonly used application of next-generation sequencing experiments. The ultimate goal is to puzzle millions of reads into one complete genome, although draft assemblies usually result in a number of gapped scaffold sequences. In this paper we propose an automated strategy, called GapFiller, to reliably close gaps within scaffolds using paired reads. The method shows good results on both bacterial and eukaryotic datasets, allowing only few errors. As a consequence, the amount of additional wetlab work needed to close a genome is drastically reduced. The software is available at http://www.baseclear.com/bioinformatics-tools/.
PALPATION HEMATURIA AS A TEST IN FLOATING KIDNEY
Authors: Morris H. Kahn
Journal: JAMA (1924)

In examining cases of nephroptosis, I wanted to ascertain whether palpation of the kidney and the pressure incident to it were of any direct injury to the organ; also, when it was desired to identify the kidney from other palpable masses in the abdomen, whether, by producing hematuria by pressure, the identification could be made. I therefore took a series of cases and, after having the patient void, I proceeded with the routine physical examination. I palpated one or both kidneys, exerting only mild pressure during three inspirations of the patient. After a few minutes, I had the patient void again for a comparable microscopic examination. I have thus obtained data from numerous cases, in some of which I have confirmed this finding repeatedly. In many cases of nephroptosis in which the kidney could be held down by the palpating hand for several inspirations, bleeding was produced by palpation trauma.
Calcium oscillations index the extent of calcium loading and predict functional recovery during reperfusion in rat myocardium.
Authors: R G Weiss, G Gerstenblith, E G Lakatta
Journal: Journal of Clinical Investigation (1990)

Delayed recovery of contractile function after myocardial ischemia may be due to prolonged recovery of high-energy phosphates, persistent acidosis, increased inorganic phosphate, and/or calcium loading. To examine these potential mechanisms, metabolic parameters measured by 31P nuclear magnetic resonance spectroscopy, and spontaneous diastolic myofilament motion caused by sarcoplasmic reticulum-myofilament calcium cycling indexed by the scattered light intensity fluctuations (SLIF) it produces in laser beam reflected from the heart, were studied in isolated atrioventricularly blocked rat hearts (n = 10) after 65 min of ischemia at 30 degrees C. All metabolic parameters recovered to their full extent 5 min after reperfusion. Developed pressure evidenced a small recovery but then fell abruptly. This was accompanied by an increase in end diastolic pressure to 37 +/- 5 mm Hg and a fourfold increase in SLIF, to 252 +/- 58% of baseline. In another series of hearts initial reperfusion with calcium of 0.08 mM prevented the SLIF rise and resulted in improved developed pressure (74 +/- 3% vs. 39 +/- 13% of control), and lower cell calcium (5.9 +/- 3 vs. 10.3 +/- 1.4 mumol/g dry wt). Thus, during reperfusion, delayed contractile recovery is not associated with delayed recovery of pH, inorganic phosphate, or high-energy phosphates and can be attributed, in part, to an adverse effect of calcium loading which can be indexed by increased SLIF occurring at that time.
Additional Value of Transluminal Attenuation Gradient in CT Angiography to Predict Hemodynamic Significance of Coronary Artery Stenosis
Authors: Wynand J. Stuijfzand, Ibrahim Danad, Pieter G. Raijmakers, C. Bogdan Marcu, Martijn W. Heymans, Cornelis C. van Kuijk, Albert C. van Rossum, Koen Nieman, James K. Min, Jonathon Leipsic, Niels van Royen, Paul Knaapen
Journal: JACC. Cardiovascular imaging (2014)
Intratumoral genomic heterogeneity in human hepatocellular carcinoma detected by restriction landmark genomic scanning
Authors: Rieko Saeki, Hisaki Nagai, Shuichi Kaneko, Masashi Unoura, Naoki Yamanaka, Eiso Okamoto, Kenichi Kobayashi, Kenichi Matsubara
Journal: Journal of Hepatology (2000)
Higher prices and plain packaging are part of plan to halve smoking in France by 2025
Authors: P. Benkimoun
Journal: BMJ (2012)

The French government has been given a 10 point plan to tackle the country’s high prevalence of smoking, which at 29% is the highest in Europe. The aim is to halve tobacco consumption by 2025.

A report commissioned by the Ministry of Health and delivered to parliament on 1 March calls for a cross department policy to reduce dependence on tobacco in France, to be led by the prime minister. It recommends a new tax on tobacco companies, according to their volume of sales, and ringfencing a portion of tobacco sales taxes to pay for preventive and treatment strategies.

The report also calls …
PRESENT STATUS OF SPECIFIC DRUG TREATMENT OF TUBERCULOSIS
Authors: Carl W. Tempel
Journal: JAMA (1952)

During the past six years Fitzsimons Army Hospital has participated in the 11 conferences on chemotherapy of tuberculosis sponsored by the Veterans Administration, at which the experiences of 44 hospitals (Veterans Administration, Army, and Navy) have been carefully recorded and analyzed. 1 The latest report of this work on approximately 10,000 cases is now a matter of record. During the period of these studies, the tuberculosis service of this hospital, with an average census of 1,000 patients, has had the opportunity of evaluating antibacterial agents used in the treatment of this disease in adults. The clinical material available has been particularly suitable for pilot studies on the therapeutic effectiveness, bacterial resistance, and toxicity of new drugs and combinations of drugs (table 1). In spite of these experiences and all the excellent reference material available in the literature, it still remains a monumental task to place specific drug therapy of pulmonary
Manifestations of Crohn's Disease -- Uric Acid Stones in Crohn's Disease
Authors: C D Flombaum
Journal: New England Journal of Medicine (1994)

Figure 1. Uric Acid Stones in Crohn's Disease. An intravenous urogram was obtained in a 37-year-old woman with persistent watery diarrhea. She had had Crohn's disease for 11 years, and most of her colon and part of her ileum had been removed 4 years earlier. A large radiolucent defect occupies most of the left renal pelvis (large arrow), and a smaller defect obstructs the lower pole calix of the left kidney (small arrow). The right kidney appears to be normal. Three years after this study was performed, similar stones developed in the right kidney. These were found to contain uric . . .
A de novo heterozygous point mutation in the p63 gene causing the syndrome of ectrodactyly, ectodermal dysplasia and facial clefting
Authors: G. Pozo, S. Canun, S. Kofman-Alfaro, J.C. Zenteno
Journal: British Journal of Dermatology (2004)

Sir, Ectodermal dysplasias (EDs) include a large and complex group of genetic diseases characterized by defects in the development of hair, nails, teeth and sweat glands.1 The association of ED and clefting of the lip and/or palate (CL/P) has been recognized in a number of clinical entities.2 The three most common of these are EEC syndrome, characterized by ED, ectrodactyly (a malformation defined by varying degrees of central longitudinal fissuring in the hand and/or foot) and CL/P;3 Rapp–Hodgkin syndrome, consisting of ED, CL/P and midfacial hypoplasia;4 and AEC syndrome, defined by ankyloblepharon (congenital fusion of the margins of the eyelids), ectodermal defects and CL/P.5 Recently, the molecular cause of EEC syndrome has been shown to involve point mutations in the p63 gene,6, 7 a homologue of the tumour suppressor gene p53. Interestingly, localized mutations in p63 also result in AEC and Rapp–Hodgkin syndromes,8, 9 confirming the previously suggested notion that these disorders are variable clinical manifestations of the same molecular defect. Virtually all p63 mutations causing EEC syndrome are located in exons 4–8, the region coding for the DNA‐binding domain (DBD) of the protein.9 We describe the clinical and molecular data of a patient with a classical EEC phenotype in whom a de novo point mutation was identified in exon 5 of p63.
A new approach to weighted capitation
Authors: K Judge, N Mays
Journal: BMJ (1994)

Equity of access to health care on the basis of need alone is the central principle of the NHS. A corollary of this is that resources should be distributed among local health authorities in proportion to their relative health care needs. But this is difficult in practice because population needs cannot be measured directly and the proxies that are available are difficult to interpret.

Since the publication of the report of the Resource Allocation Working Party in 1976,1 the allocation of resources to hospital and community health services has become progressively more complicated and controversial.2,3 The review of the Resource Allocation Working Party's formula in 1988, which resulted in the introduction of a weighted capitation formula, was widely criticised.4,5 Particular concern was expressed about how analyses of variations in hospital use among small areas were used to generate indicators of need.

Prompted by the availability of new data from the census in 1991, the secretary of state for health announced a review of weighted capitation at the beginning of last year. Later this week ministers …
Erythrocyte Deformability in Uremic Hemodialyzed Patients
Authors: S. FORMAN
Journal: Annals of Internal Medicine (1973)

Erythrocyte deformability was measured in normal people and in patients with chronic renal failure treated with hemodialysis. This was accomplished by the measurement of flow rate through polycarbonate filters with pore diameters of 3 microns. Erythrocytes with altered flow rates were found in five of seven splenectomized patients with chronic renal failure. Splenectomized individuals with normal renal function did not show this effect on the erythrocytes. The cells of 14 other patients on dialysis, who had spleens, showed normal flow-rate characteristics. This suggests that part of the hemolytic component of the anemia of chronic renal failure may be associated with cellular alterations that compromise the passage of erythrocytes through the microcirculation of the spleen. The improvement of the hemolytic anemia of uremia after splenectomy may be associated with the persistence of these rigid cells in the circulation.
DOES PLATELET FUNCTION TESTING ADD SIGNIFICANT INCREMENTAL RISK STRATIFICATION TO UNSELECTED PATIENTS UNDERGOING DES IMPLANTATION? THE ADAPT-DES STUDY
Authors: Ajay J. Kirtane, Helen Parise, Bernhard Witzenbichler, Giora Weisz, Michael Rinaldi, Franz-Josef Neumann, David Metzger, Timothy Henry, David Cox, Peter Duffy, Bruce Brodie, Thomas Stuckey, Ernest Mazzaferri, Ecaterina Cristea, Roxana Mehran, Gregg Stone
Journal: Journal of the American College of Cardiology (2012)