Miconazole in Cryptococcosis and Systemic Candidiasis: A Word of Caution
Authors: John E. Bennett, Jack S. Remington
Journal: Annals of Internal Medicine (1981)

Editorial Note1 May 1981Miconazole in Cryptococcosis and Systemic Candidiasis: A Word of CautionJOHN E. BENNETT, M.D., JACK S. REMINGTON, M.D.JOHN E. BENNETT, M.D.Search for more papers by this author, JACK S. REMINGTON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-5-708 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn article in a recent issue of this journal reported the use of intravenous miconazole in cryptococcosis (1). Use of this new antifungal drug in the treatment of systemic candidiasis as well as cryptococcosis appears to be increasing. Whereas relatively few infectious disease specialists use intravenous miconazole for these indications, we believe that this drug is used much more frequently by physicians working outside the subspecialty of infectious disease. If our impression is correct, then these groups differ in the interpretation of the meager data on the efficacy of miconazole in treating these diseases. Alternatively, some physicians may be relying...References1. WEINSTEINJACOBY LI. Successful treatment of cerebral cryptococcoma and meningitis with miconazole. Ann Intern Med. 1980;93:569-71. LinkGoogle Scholar2. GRAYBILLLEVINE JH. Successful treatment of cryptococcal meningitis with intraventricular miconazole. Arch Intern Med. 1978;138:814-6. CrossrefMedlineGoogle Scholar3. KRICKREMINGTON JJ. Treatment of fungal infections. Arch Intern Med. 1975;135:344-6. Editorial. CrossrefMedlineGoogle Scholar4. YOUNGBENNETTGEELHOEDLEVINE RJGA. Fungemia in patients with compromised host resistance: a study of 70 cases. Ann Intern Med. 1974;80:605-12. LinkGoogle Scholar5. SUNGRAJANICHOPRAGRENDAHLHAWS JKDJE. Miconazole therapy for systemic candidiasis in a conjoined (Siamese) twin and a premature newborn. Am J Surg. 1979;138:688-91. CrossrefMedlineGoogle Scholar6. JORDANBODEYRODRIGUEZKETCHELHENNEY WGVSJ. Miconazole therapy for treatment of fungal infections in cancer patients. Antimicrob Agents Chemother. 1979;16:792-7. CrossrefMedlineGoogle Scholar7. KATZCASSILETH MP. Disseminated candidiasis in a patient with acute leukemia: successful treatment with miconazole. JAMA. 1977;237:1124-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDevelopment of drugs based on imidazole and benzimidazole bioactive heterocycles: recent advances and future directionsAzole antifungals: 35 years of invasive fungal infection managementHistory of the development of azole derivativesUse of Azoles for Systemic Antifungal TherapyAntifungal chemotherapy and drug strategies: Projected clinical needsAdditive TherapieFungal infections in the immunocompromised hostIn vitro and in vivo evaluation of antifungal agentsTreatment of systemic fungal infections: Recent progress and current problemsIntracranial hypertension causing visual failure in cryptococcus meningitis.Overview of medically important antifungal azole derivativesAntifungal Agents Used for Deep-Seated Mycotic Infections14 Infection and Transfusion Therapy in Acute LeukaemiaMiconazole inhibition of platelet aggregation by inhibiting cyclooxygenaseMalasezzia furfur sepsis in neonatesManagement of the Immunocompromised HostPediatric Antifungal ChemotherapyNeonatal systemic candidiasis.Miconazole in systemic candidiasis.Pathological Cry, Stridor, and Cough in InfantsAntifungal ChemotherapyDiagnosis and Treatment of Acquired Immune Deficiency States and Opportunistic InfectionsOral prophylaxis with miconazole or ketoconazole of invasive fungal disease in neutropenic cancer patientsHematogenous candida vertebral osteomyelitis treated with ketoconazoleThese articles bring the series to an end. We renew our thanks to Professor Geddes for generous help with planning and presentation.Chapter 15 Antifungal Chemotherapy 1 May 1981Volume 94, Issue 5Page: 708-709KeywordsAntifungalsCandidiasisCryptococcosisDrugsInfectious diseasesSub-specialty care Issue Published: 1 May 1981 PDF DownloadLoading ...