tbuckley/cabot-search huggingface dataset:
Engaging to No Avail
Authors: Irene M. Wielawski
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division
Authors: John T. Chang, Maria L. Ciocca, Ichiko Kinjyo, Vikram R. Palanivel, Courtney E. McClurkin, Caitlin S. DeJong, Erin C. Mooney, Jiyeon S. Kim, Natalie C. Steinel, Jane Oliaro, Catherine C. Yin, Bogdan I. Florea, Herman S. Overkleeft, Leslie J. Berg, Sarah M. Russell, Gary A. Koretzky, Martha S. Jordan, Steven L. Reiner
Journal: Immunity (2011)
CHRONIC BILIARY TRACT DISEASE AND PLASMACYTIC DYSCRASIA
Authors: JONATHAN S. KRAUSS
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 April 1969CHRONIC BILIARY TRACT DISEASE AND PLASMACYTIC DYSCRASIAJONATHAN S. KRAUSSJONATHAN S. KRAUSSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-4-869_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:In a recent NIH Clinical Staff Conference (Ann. Intern. Med. 69 803, 1968) the following statement appeared: "This paraproteinemia may represent a limited plasma cell response to a yet undefined chronic stimulus. Osserman and Fahey have recently reported ahigh prevalence[the italics are mine] of chronic biliary tract disease in patients with plasma cell dyscrasia and paraproteins that is consistent with such a hypothesis" (1). The "high prevalence" referred to above is really 10% (2). I recently completed a study of 51 patients with plasmacytic dyscrasia at the Shands Teaching Hospital, Gainesville, Fla., which reconfirmed Dr....References1. BARTHGLENNERWALDMANNZELIS WFGFTARF: Primary amyloidosis. Ann. Intern. Med. 69: 803, 1968. LinkGoogle Scholar2. OSSERMANFAHEY EFJL: Plasma cell dyscrasia—current clinical and biochemical concepts. Amer. J. Med. 44: 256, 1968. CrossrefMedlineGoogle Scholar3. SCHIFF L: Diseases of the Liver, 2nd ed., J. B. Lippincott Co., Philadelphia, 1963, p. 832. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Florida Gainesville, Fla. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1969Volume 70, Issue 4Page: 869-869KeywordsBiliary systemPlasma cells Issue Published: 1 April 1969 PDF DownloadLoading ...
Reuse of Twin-Coil Disposable Artificial Kidneys With Their Priming Blood
Authors: Mordechai Tchetchik
Journal: JAMA (1966)

HEMODIALYSIS is a well-established treatment for acute<sup>1</sup>as well as for chronic uremia.<sup>2,3</sup>The era of hemodialysis at home is just beginning. In a renal transplantation program, hemodialysis prepares the recipient for operation and treats the anuria which usually follows the use of cadaver kidneys.<sup>4-6</sup> Twin-coil kidneys<sup>7</sup>have several advantages: ease and speed of assembly, the short time required for dialysis, and the elimination of postdialysis cleaning. Their major disadvantages are the high cost of disposable parts and the large amount of blood necessary for priming. Expense is greatly lessened when disposable kidneys and their contained blood can be reused. Great care should be taken to return the used coil to the same patient who used it previously. <h3>Material and Methods</h3> Two types of twin-coil kidneys were used, designated here as A and B. Type A is an ordinary twincoil kidney with approximately 11 meters of
Contraception Sine Comstockery
Authors: Somers H. Sturgis
Journal: New England Journal of Medicine (1970)

ON July 6, 1970, Judge Bailey Aldrich, of the United States Court of Appeals for the First Circuit, in a classic decision, upset previous rulings by the Massachussetts Supreme Judicial Court and declared that Massachusetts General Law c. 272 21 was unconstitutional and void so far as it dealt with birth control. This ancient statute was part of the so-called Comstock Law dealing with alleged "Crimes against Chastity, Morality and Good Order." In the present case the Circuit Court, with the Honorable Bailey Aldrich as chief judge, unanimously declared that the petitioner, William R. Baird, was within his rights, and . . .
Barbiturate Poisoning Treated with Picrotoxin and Colonic Lavage
Authors: R. W. Bazeley, P. H. Garrard
Journal: BMJ (1948)

<h3>Abstract</h3> The Coronavirus Disease (COVID-19) pandemic has brought significant impact onto the maritime activities worldwide, including disruption to global trade and supply chains. The ability to predict the evolution and duration of a COVID-19 outbreak on cargo vessels would inform a more nuanced response to the event and provide a more precise return-to-trade date. A SEIQ(H)R (Susceptibility–Exposed– Infected–Quarantine–(Hospitalisation)–Removed/Recovered) model is developed and fit-tested to simulate the transmission dynamics of COVID-19 on board cargo vessels of up to 60 crew. Due to specific living and working circumstances on board cargo vessels, instead of utilising the reproduction number, we consider the crew members from the same country to quantify the transmission of the disease. The performance of the model is verified using case studies based on data collected during COVID-19 outbreaks on three cargo vessels in Western Australia during 2020. The convergence between simulation results and the data verifies the performance of the model. The simulations show that the model can forecast the time taken for the transmission dynamics on each vessel to reach their equilibriums, providing informed predictions on the evolution of the outbreak, including hospitalisation rates and duration. The ability to model the evolution of an outbreak, both in duration and severity, is essential to predict outcomes and to plan for the best response strategy. At the same time, if offers a higher degree of certainty regarding the return to trade, which in turn is of significant importance to multiple stakeholders.
Recombinant Factor VIIa in the Management of Pulmonary Hemorrhage Associated With Metastatic Choriocarcinoma
Authors: Matthew J. Wheater, Graham M. Mead, Sandeep Bhandari, Jonathan Fennell
Journal: Journal of Clinical Oncology (2008)

highly sensitive to chemotherapy, because the rapid shrinkage of hepatomegaly was observed despite discontinuation of chemotherapy after cisplatin and only 3 days of capecitabine.Finally, cisplatin is nephrotoxic, and therefore would potentially have aggravated azotemia that was complicated by TLS.Although there may be a possibility that azotemia was attributed to nephrotoxicity of cisplatin in the present case, it is less likely because nephrotoxicity of cisplatin is typically accompanied by nonoliguric azotemia and develops slowly and predictably after repeated exposure, unlike this case.Considering our experience, precautions should be taken to avoid this potentially fatal complication when treating even solid tumors, especially therapy-sensitive tumors presenting with bulky or rapidly progressive disease and pre-existing risk factors, such as azotemia, an elevated LDH, and hyperuricemia.To the best of our knowledge, this is the first case report describing TLS following chemotherapy for AGC.Although TLS occurs rarely in patients with solid tumors including AGC, bulky tumors with a rapid doubling time or high sensitivity to antineoplastic treatments can induce TLS.Patients at risk require adequate monitoring and preventive measures, and appropriate therapeutic measures must be initiated promptly when TLS is encountered.
Current Status of Xenotransplantation
Authors: Richard N. Pierson
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Establishing the Cause of Genitourinary Symptoms in Women in a Family Practice
Authors: Alfred O. Berg
Journal: JAMA (1984)

We conducted a prospective study comparing the diagnostic yield of standard clinical examinations and of comprehensive microbiological studies in establishing the etiology of genitourinary (GU) symptoms and the prevalence of GU tract infections in 204 women seen in a university-based family practice. Two thirds were initially seen with GU symptoms and one third were seen for routine examinations. In each case we obtained demographic and historical information, a physical examination, and a variety of laboratory tests, including research procedures not commonly available. Diagnoses considered were urinary tract infection and sterile pyuria; trichomonal, yeast, and nonspecific vaginitis; and GU tract infection with<i>Neisseria gonorrhoeae, Chlamydia trachomatis</i>, or herpes simplex virus. Using strategies commonly employed in practice, we reached a diagnosis in only 34% of symptomatic women, a figure rising to 66% when selected, nonroutine laboratory examinations were added. (<i>JAMA</i>1984;251:620-625)
A painful swollen finger
Authors: N. Al-Hadithy, A. Panagiotidou, S. Hamilton
Journal: BMJ (2012)

A 44 year old right hand dominant gardener presented to the emergency department with a two day history of a painful right ring finger. On closer questioning he had been weeding and pruning three days before presentation. He had not been wearing gloves but could not recall any unusual event. He had no relevant medical history.

On examination, the ring finger was swollen and tender along its length, with a blister on the radial aspect. The finger was warm compared with his other fingers, and capillary refill was less than 2 seconds. The finger was kept in flexion at the proximal interphalangeal and metacarpophalangeal joints and passive stretch caused intense pain. 



### 1 What is the diagnosis?

#### Short answer

Flexor sheath infection, also known as infectious flexor tenosynovitis or pyogenic tenosynovitis

#### Long answer

Infectious flexor tenosynovitis is the inoculation of an infectious agent within the enclosed space of the flexor sheath and multiplication of the organism in the culture rich synovial medium.1

Diagnosis is made by history and clinical examination to elicit Kanavel’s signs (fig 1⇓).



Fig 1 Clinical image of swollen painful right ring finger 



Kanavel’s signs include2:

Intense pain on passive stretch is the most clinically reproducible of these four signs,3 4 with tenderness along the tendon sheath being the second most reproducible.5

The presence of all four signs is pathognomonic of pyogenic flexor tenosynovitis. However, a recent study showed that all …
COLON FILLING STATIONS
Authors: Frank Smithies
Journal: JAMA (1926)

<h3>To the Editor:</h3> —Chicago has long been regarded by "twilight zone" practitioners as a lucrative and well protected hunting ground. Now we are being visited and exploited by the "colon therapists." During the last two years, New York, Boston, Philadelphia, Pittsburgh and even Baltimore have had their colonic "sewers" catheterized, irrigated and bug-implanted. Now Chicago must take its place in the ranks of the "autointoxicated," the "pepless," the "bugless" and the "pale and pasty." "Colonic therapy" has had an interesting and not unenlightening history. The Metchnikoff "chemists" gave it birth, but not until Sir Arbuthnot Lane fostered it with the vivid fanaticism of a "Billy" Sunday did the "poisonous cesspool" of man parade in accepted medical society. The disappointments that followed the myriad resections, "short-circuits" and entro-anastomoses advocated by Lane and his co-workers permitted this "new birth" therapy to languish, and up to three years since, the defenseless colon—to whose
Volatile fatty acids in the faeces of patients in `germ-free' isolation
Authors: D. Gompertz, A. P. Brooks, H. Gaya, A. S. D. Spiers
Journal: Gut (1973)

Faecal volatile fatty acids represent the end products of the metabolism of the anaerobic flora of the large bowel. The excretion of these volatile acids has been investigated in five leukaemic patients maintained in plastic `germ-free9 isolators. Under `isolator9 conditions there is a pronounced fall in volatile fatty acid excretion. The possibility that the measurement of these acids may be used to monitor anaerobic overgrowth and recolonization in these patients is discussed.
The Value of DNKs
Authors: Susan Mackie
Journal: New England Journal of Medicine (2010)

Smiling and joking, having realized that her medical problems were in good hands, Ms. W. rose to leave my exam room. Knowing that my residency is limited in time, she asked nervously how long I would be in the practice — and expressed relief when I told her that I would be here with her for the next few years. I returned her smile, and the warm emotion I expressed was genuine. I had helped her, she trusted me, and I was doing what I loved. Ms. W.'s appointment was my last one for the day. I would go home . . .
Gene Therapy Using a Liver-targeted AAV Vector Restores Nucleoside and Nucleotide Homeostasis in a Murine Model of MNGIE
Authors: Javier Torres-Torronteras, Carlo Viscomi, Raquel Cabrera-Pérez, Yolanda Cámara, Ivano Di Meo, Jordi Barquinero, Alberto Auricchio, Giuseppe Pizzorno, Michio Hirano, Massimo Zeviani, Ramon Martí
Journal: Molecular Therapy (2014)

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder caused by mutations in TYMP, enconding thymidine phosphorylase (TP). TP deficiency results in systemic accumulation of thymidine and deoxyuridine, which interferes with mitochondrial DNA (mtDNA) replication and leads to mitochondrial dysfunction. To date, the only treatment available for MNGIE patients is allogeneic hematopoietic stem cell transplantation, which is associated with high morbidity and mortality. Here, we report that AAV2/8-mediated transfer of the human TYMP coding sequence (hcTYMP) under the control of a liver-specific promoter prevents the biochemical imbalances in a murine model of MNGIE. hcTYMP expression was restricted to liver, and a dose as low as 2 × 1011 genome copies/kg led to a permanent reduction in systemic nucleoside levels to normal values in about 50% of treated mice. Higher doses resulted in reductions to normal or slightly below normal levels in virtually all mice treated. The nucleoside reduction achieved by this treatment prevented deoxycytidine triphosphate (dCTP) depletion, which is the limiting factor affecting mtDNA replication in this disease. These results demonstrate that the use of AAV to direct TYMP expression in liver is feasible as a potentially safe gene therapy strategy for MNGIE. Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder caused by mutations in TYMP, enconding thymidine phosphorylase (TP). TP deficiency results in systemic accumulation of thymidine and deoxyuridine, which interferes with mitochondrial DNA (mtDNA) replication and leads to mitochondrial dysfunction. To date, the only treatment available for MNGIE patients is allogeneic hematopoietic stem cell transplantation, which is associated with high morbidity and mortality. Here, we report that AAV2/8-mediated transfer of the human TYMP coding sequence (hcTYMP) under the control of a liver-specific promoter prevents the biochemical imbalances in a murine model of MNGIE. hcTYMP expression was restricted to liver, and a dose as low as 2 × 1011 genome copies/kg led to a permanent reduction in systemic nucleoside levels to normal values in about 50% of treated mice. Higher doses resulted in reductions to normal or slightly below normal levels in virtually all mice treated. The nucleoside reduction achieved by this treatment prevented deoxycytidine triphosphate (dCTP) depletion, which is the limiting factor affecting mtDNA replication in this disease. These results demonstrate that the use of AAV to direct TYMP expression in liver is feasible as a potentially safe gene therapy strategy for MNGIE.
Case 17-1980
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Joseph B. Martin, George M. Kleinman
Journal: New England Journal of Medicine (1980)

Presentation of Case First admission. A 60-year-old man was admitted to the hospital because of anorexia. He was well until two months previously, when anorexia, fatigue, and dyspnea developed, and he entered another hospital because of a question of pneumonia. Laboratory studies revealed that the thyroxine was reduced; the triiodothyronine resin uptake was normal. Thyroid hormone, 60 mg daily, was prescribed, and erythromycin was given. After discharge anorexia persisted, with occasional vomiting and a loss of 4 kg in weight. He was referred to this hospital.The temperature was 36.8°C, the pulse 92, and the respirations 18. The blood . . .
Groups Call Truce Over Metabolic Syndrome
Authors: Mike Mitka
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Natural hormone shows "promise" in IVF, say scientists
Authors: M. Limb
Journal: BMJ (2014)

Research into a new method to stimulate ovulation in women who are undergoing in vitro fertilisation (IVF) treatment has produced “promising” results, say scientists. Twelve healthy babies were born to 10 women after 53 women were given a single injection of the natural hormone kisspeptin to mature their eggs.

Researchers described the pregnancy rate of 23% (12 of 53) as a “good outcome” when compared with standard conventional IVF therapy.

The trial was carried out by Imperial College London and Imperial College Healthcare NHS Trust and funded by the Medical Research Council, the National Institute for Health Research, and the Wellcome Trust. The findings were published on 18 July in the Journal of Clinical Investigation .1 …
Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection.
Authors: B Rehermann, D Lau, J H Hoofnagle, F V Chisari
Journal: Journal of Clinical Investigation (1996)

Clearance of the hepatitis B virus (HBV) during acute hepatitis is associated with a strong, polyclonal, multispecific cytotoxic T lymphocyte (CTL) response to the viral envelope, nucleocapsid and polymerase proteins that persists for decades after clinical recovery. In contrast, chronically infected patients usually fail to mount a strong CTL response to this virus. In this study we demonstrate that chronically infected patients who experience a spontaneous or interferon-induced remission develop a CTL response to HBV that is similar in strength and specificity to patients who have recovered from acute hepatitis. The results suggest that specific immunotherapeutic enhancement of the CTL response to HBV should be possible in chronically infected patients, and that it could lead to viral clearance in these individuals with resolution of chronic liver disease.