tbuckley/cabot-search huggingface dataset:
FIBROUS NASAL POLYPUS.
Authors: D. R. SILVER
Journal: JAMA (1897)

quence of acute perichondritis it is ushered in during a few days by symptoms indicating a high degree of inflammation, e. g., chill, pronounced fever, pain, swelling and redness of the whole organ.Spontane- ous rupture is more apt to occur quickly in this than in the former type, although it may be much delayed after the subsidence of the inflammatory symp- toms, leaving again nasal obstruction as the salient symptom.Case 2 exemplifies the latter type.-Mr.B., aged 26 years; thought he had contracted a severe "cold in the head," the condition commencing with chilly sensations followed by head ache, fever, local sensitiveness and redness extending to the bridge of the nose.These symptoms gradually subsided but were replaced by nasal obstruction and what he now supposed was chronic nasal catarrh.The examination was not made
Antigen Crosspresentation by Human Plasmacytoid Dendritic Cells
Authors: Guillaume Hoeffel, Anne-Claire Ripoche, Diana Matheoud, Michelina Nascimbeni, Nicolas Escriou, Pierre Lebon, Farhad Heshmati, Jean-Gérard Guillet, Monique Gannagé, Sophie Caillat-Zucman, Nicoletta Casartelli, Olivier Schwartz, Henri De la Salle, Daniel Hanau, Anne Hosmalin, Concepción Marañón
Journal: Immunity (2007)
Cervical cancer screening: Liquid based cytology is successful
Authors: M. W Whitley
Journal: BMJ (2003)

EDITOR—The results of Coste et al should be interpreted with some caution.1 They raise questions about the validity of such a small group of 2585 and of split sampling. An analysis is required on the amount of training of smear takers, laboratory staff, and cytopathologists. The contrast in appearance between conventional smears and thin …
What's Wrong With J?
Authors: Don B. Smith
Journal: JAMA (1988)

<h3>To the Editor.—</h3> I made a discovery the other day while browsing through my 1988 edition of the<i>Physicians' Desk Reference</i>. It is a minor revelation, I'll grant you, and I'm sure that others have noticed it before me. But it's such a curious thing, I couldn't resist calling attention to it. Pharmaceutical companies presumably spend a great deal of creative energy giving their products highly memorable and distinctive names. One would suppose that coming up with a truly unique name would be difficult. Why is it, then, that one may find drug names beginning with any letter of the alphabet except one? What's wrong with<i>J</i>?
Relationship of Plasma Digitoxin and Digoxin to Cardiac Response Following Intravenous Digitalization in Man
Authors: WILLIAM SHAPIRO, KENNETH NARAHARA, KATHRYN TAUBERT
Journal: Circulation (1970)

The value of plasma digitalis determinations will depend upon the accuracy with which they mirror the myocardial effects of digitalis. Ten volunteers received 0.8 mg of digitoxin intravenously, and after 2 hours the mean plasma digitoxin level was 45.6 ± 6 mµg/ml but declined over 4 to 6 hours during plasma-tissue equilibration. The cardiac response, as indicated by decreases in the left ventricular ejection time index (LVETI) and Q-S 2 intervals ( P &lt; 0.01), was present at 2 hours and reached maximum at 4 to 6 hours. Subsequently, plasma level, LVETI, and Q-S 2 changed in the same direction during slow excretion. Six subjects received 1.0 mg of digoxin intravenously. Mean plasma digoxin at 30 min was 6.8 ± 0.3 mµg/ml; it fell after 3 to 4 hours to levels usually seen during maintenance digoxin administration (&lt;3 mµg/ml) and then declined more slowly. Correlation of individual digoxin levels with ΔLVETI values during the first 4 hours was significant ( P &lt; 0.01). The half-life (T ½ ) for the dominant slope of the plasma curve was 30.5 hours by plasma determinations and 29 hours by LVETI determination. Plasma levels of digitoxin and digoxin were related to their cardiac effects under the conditions studied. Prior to plasma-tissue equilibration, plasma determinations of digoxin and digitoxin will be higher than levels seen during maintenance administration of these drugs.
Coffee Consumption Is Associated With Higher Plasma Adiponectin Concentrations in Women With or Without Type 2 Diabetes
Authors: Kazuhiko Kotani, Shinji Fujiwara, Taku Hamada, Kokoro Tsuzaki, Naoki Sakane
Journal: Diabetes Care (2008)

Williams et al. reported that women consuming ≥4 cups of coffee daily had higher adiponectin levels than those consuming lower amounts, regardless of the presence of diabetes (1). They found that regular coffee consumption has beneficial effects on low-grade systemic inflammation and type 2 diabetes incidence and that adiponectin may be involved in the mechanism (1). Given variances in different ethnicities' social cultures regarding coffee consumption and in adiponectin levels across ethnicity (2), Williams et al.'s data should be confirmed on various populations. Also up for discussion is whether the data are applicable to men because of the sex-based differences in adiponectin …
Family Development in a Changing World
Authors: ALICE S. ROSSI
Journal: American Journal of Psychiatry (1972)

Over the past half century, increased longevity and fertility control have had a marked effect on family structure. Women now devote a smaller proportion of their adult life to the rearing of children; they have also achieved higher levels of education, which has facilitated more egalitarian relations between husbands and wives and has increased the proportion of married women who are capable of holding jobs. To reshape one's personal goals to keep pace with these social changes is a complex and difficult task. The author points out some of the pitfalls and also notes that the feminist movement may ease the transition.
ISOLATION OF B VIRUS (HERPES GROUP) FROM THE CENTRAL NERVOUS SYSTEM OF A RHESUS MONKEY
Authors: Joseph L. Melnick, Dushyant D. Banker
Journal: The Journal of Experimental Medicine (1954)

While passaging a recently isolated strain of poliomyelitis virus through a rhesus monkey, another virus was procured from its central nervous system. After intracerebral inoculation, the virus produced meningoencephalitis in monkeys, cotton rats, hamsters, guinea pigs, and rabbits; after intracutaneous inoculation a necrotic skin lesion was produced in the monkey and rabbit and this was often followed by myelitis. The virus could also be passed in newborn mice less than 48 hours old and in chick embryos by inoculation of the chorioallantoic membrane. Immunological and host range studies revealed this virus to be related to the B virus originally described by Sabin and Wright in 1934 (1). To our knowledge this is the first record of B virus having been isolated from a monkey, and lends support to the inclusion of this agent as the simian member of the herpes group. The infection is not uncommon in monkey stocks, as revealed by the finding of antibodies to the virus in their sera. In the present series 9 of 44 monkeys gave positive antibody tests. Gamma globulin prepared in the United States in 1945, 1951, and 1953, as well as a certain proportion of sera from normal individuals in Bombay, India, and elsewhere, showed neutralizing activity against the new strain of B virus, and also to herpes simplex virus. This may be the result of the partial crossing which exists between the two viruses.
Comparison of proteomic and genomic analyses of vaccine cell lines shows men receiving prostate gvax immunotherapy develop increased humoral responses to common cell line proteins relative to mutated proteins
Authors: Tyler Hulett, Sachin Puri, Brendan Curti, Walter J Urba, Bernard A Fox
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Recent work by Rosenberg, et. al. demonstrates the role of mutated epitopes in natural anti-cancer adaptive immunity. This has led some to hypothesize that cancer vaccines may need to induce or augment immunity against mutated and potentially patient-specific epitopes to achieve
Review: Acetaminophen reduces acute migraine pain in adults
Authors: Alexander W. Chessman
Journal: Annals of Internal Medicine (2011)

ACP Journal Club15 March 2011Review: Acetaminophen reduces acute migraine pain in adultsAlexander W. Chessman, MDAlexander W. Chessman, MDMedical University of South Carolina, Charleston, South Carolina, USA (A.W.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-6-201103150-02009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationDerry S, Moore RA, McQuay HJ. Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults. Cochrane Database Syst Rev. 2010;(11):CD008040. https://pubmed.ncbi.nlm.nih.gov/21069700Clinical Impact RatingsGIM/FP/GP: Emergency Med: Neurology: Reference1 McCrory DC, Gray RN. Oral sumatriptan for acute migraine. Cochrane Database Syst Rev. 2003;(3):CD002915. [PMID: 12917936] Google Scholar Author, Article, and Disclosure InformationAuthors: Alexander W. Chessman, MDAffiliations: Medical University of South Carolina, Charleston, South Carolina, USA (A.W.C.)This article was published at Annals.org on 1 March 2011. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 2011Volume 154, Issue 6Page: JC3-9KeywordsAdverse eventsDatabasesHeadachesMigraineNumber needed to harmNumber needed to treatPatientsResearch designRisk ratioSafety ePublished: 15 March 2011 Issue Published: 15 March 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Patients who have had fractures of the distal forearm do not lose bone as expected
Authors: R W Keen, G O Griffiths, T D Spector
Journal: BMJ (1996)

their residual risk of having a child with cystic fibrosis.Couples in which one partner has no identifiable mutation and the other partner is not tested have a risk of 1 in 16100 (1/25xl/161xl/ 4); they represent 96.6% of the couples.Couples in which one partner but not the other has an identifiable mutation have a risk of 1 in 644 (1/lxl/161xl/4); they represent 3.3% of the couples.Couples in which both partners are car- riers have a risk of 1 in 4; they represent 0. 1% of the population.
Acute Intermittent Porphyria Complicated by a Secondary Abdominal Pregnancy
Authors: M. Friedman, R. W. Beard
Journal: BMJ (1963)

Acute Intermittent Porphyria Complicated by a Secondary Abdominal PregnancyAcute intermittent porphyria commonly presents as severe abdominal pain of acute onset.The abdominal signs are often mistaken for manifestations of acute appendicitis, cholelithiasis, renal colic, or perforated peptic ulcer (Calvy, 1950), and patients with porphyria may have multiple surgical scars on the abdomen.Difficulty arises in diagnosis when a patient known to have porphyria presents with a surgical emergency which has precipitated an acute attack of porphyria.We record such a case.
Late Follow-Up From RAVEL
Authors: Warren K. Laskey
Journal: Circulation (2005)

he astonishing, sometimes dismaying, pace with which drug-eluting stents (DES) have made the transition from their bench origins 1,2 to proof of principle, 3 hypothesis testing, 4 -6 and now routine clinical practice 7 leaves even the least skeptical among us breathless.With each new advance, however, we should not lose sight of the fundamental elements of evidence-based clinical practice: "Does it work?" and "Is it safe?"It is equally astonishing and dismaying to realize the enormous investments in time, money, and sheer hard work that are required to adequately answer these deceptively simple questions.Using the RAVEL trial (Randomized Study with the Sirolimus-Coated Bx Velocity Balloon-Expandable Stent in the Treatment of Patients with de Novo Native Coronary Artery Lesions) as a model, I attempt here to outline the essentials for understanding how answers to these questions are provided, or not provided.
NEUROCOGNITIVE PERFORMANCE AT RETURN TO PLAY IN ELITE YOUTH HOCKEY PLAYERS WITH SPORT-RELATED CONCUSSION
Authors: K Taylor, BL Brooks, KJ Schneider, TA Blake, CD McKay, WH Meeuwisse, KM Barlow, J Kang, CA Emery
Journal: British Journal of Sports Medicine (2014)

Background Neurocognitive recovery following sport-related concussion is important for re-injury risk reduction. In elite youth hockey, it is unknown if neurocognitive function returns to baseline values at the time of medical clearance to return to play (RTP). Objective To determine if ImPACT composite scores have returned to baseline values at the time of medical clearance to RTP. Design Prospective case series. Setting Sport Medicine Clinics (Alberta, Canada). Participants Concussed elite male and female youth (13–17 years) ice hockey players (n=68) and healthy controls (n=22) completed ImPACT and SCAT2 testing at baseline and RTP following concussion. Main outcome measurements Team therapists/trainers referred concussed players to the study sport medicine physician. The physician determined RTP via symptom resolution and SCAT2 score normalization. Physicians were blinded to ImPACT (Immediate Post-Concussion Assessment and Cognitive Testing) composite scores (verbal memory, visual memory, reaction time and visual motor), which were used to evaluate neurocognitive performance. Results Comparisons between baseline and RTP ImPACT scores were based on reliable change (RC) scores derived from a sample of healthy players tested twice at baseline within 2 weeks (RC scores with 90% CI: verbal memory +/−14; visual memory, +/−15; reaction time, +/−0.1; and visual motor, +/−8). All four ImPACT composite scores were normalized at RTP in 73.5% (95C% CI: 61.5–82.8) of concussed participants and all but one [95.5%; 95% CI:70.39–99.46) controls. In the concussed players, 25.0% (95% CI: 16.0–36.9) had 1 composite score not return to baseline at RTP. One player had three composite scores not return to baseline at RTP. Conclusions Elite hockey players are often cleared for RTP without the benefit of knowing neurocognitive performance on ImPACT. In this cohort, 25% of concussed players who were cleared to return to hockey had 1 composite score that had not yet returned to baseline. These results may have implications for tertiary prevention.
Kinetic studies of the epithelial cells of the rectal mucosa in normal subjects and patients with ulcerative colitis.
Authors: R G Shorter, R J Spencer, G A Hallenbeck
Journal: Gut (1966)

EDITORIAL COMMENT Besides its interest in providing further data on the turnover time of the rectal epithelium in normal subjects, this study shows that the mitotic duration or the turnover time is prolonged in active colitis.This finding should provide a stimulus to further kinetic studies in this disease.
PPARα Agonists Inhibit Tissue Factor Expression in Human Monocytes and Macrophages
Authors: Bernadette P. Neve, Delphine Corseaux, Giulia Chinetti, Christophe Zawadzki, Jean-Charles Fruchart, Patrick Duriez, Bart Staels, Brigitte Jude
Journal: Circulation (2001)

Background —Monocytic tissue factor (TF) expression may contribute to thrombogenicity associated with plaque rupture and may propagate thrombus formation at the site of vascular lesions. Induction of monocytic TF expression by endotoxin is mediated by the activation of transcription factors such as AP-1 and NF-κB. Both these signaling pathways are modulated by peroxisome proliferator–activated receptor-α (PPARα). Therefore, we have studied the effects of fibrates and other PPARα agonists on the expression of TF. Methods and Results —We show that PPARα protein, like primary human monocytes, is also expressed in the human monocytic THP-1 cell line. Fenofibric acid, WY14643, and GW2331 inhibited TF mRNA upregulation after stimulation of THP-1 cells with lipopolysaccharide or interleukin-1β. In primary human monocytes and macrophages, the lipopolysaccharide- or interleukin-1β–mediated induction of TF activity was also inhibited by fenofibric acid, WY14643, or GW2331. Conclusions —These data indicate that activation of PPARα results in the downregulation of the TF gene. Our results suggest a novel role for PPARα in the control of atherosclerotic plaque thrombogenicity through its effects on TF expression in monocytes and macrophages.
Abstract A42: Sensitivity and resistance to a p-AKT inhibitor in an erlotinib-sensitive model for lung cancer
Authors: Rajaa El Meskini, Philip L. Martin, Michelle Gumprecht, Alan Kulaga, Theresa Guerin, Maureen Baran, Anthony J. Iacovelli, Terry Van Dyke, Zoe Weaver
Journal: Clinical Cancer Research (2012)

Abstract Activating mutations in EGFR, such as the L858R mutation, are effective predictors of response to EGFR tyrosine kinase inhibitor (TKI) therapy. While most patients initially respond to EGFR TKIs, the majority relapse within 6-12 months, underscoring the importance of identifying therapies that enhance and prolong EGFR TKI activity in patients. Agents targeting additional nodes in the EGFR pathway have the potential to overcome such resistance but single-agent activity must be understood first. We utilized mice engineered to develop erlotinib-sensitive lung adenocarcinomas driven by the human EGFR L858R mutation to evaluate the efficacy of a p-AKT inhibitor, MK-2206, currently in clinical trials for a variety of solid tumor malignancies. MK-2206 concentration and target activity were assessed in short-term PK/PD studies in both the lungs and blood of tumor-bearing mice. MK-2206 was then evaluated in an efficacy study using a twice-weekly dosing regimen, both as a single agent and in combination with other TKIs. MK-2206 alone resulted in tumor regression or tumor growth inhibition in ∼50% of the mice, but exhibited greater efficacy in combination with other upstream pathway inhibitors. Temporal evaluation of tumor growth inhibition indicated that MK-2206 was most effective at early time points and did not produce a sustained pathway and growth response as treatment continued. Analysis of gene expression changes in mice treated with MK-2006 alone vs. MK-2206 in combination with EGFR TKIs highlighted the pathways perturbed by both drugs.
Endobronchial and endoscopic ultrasound-guided real-time fine-needle aspiration for mediastinal staging
Authors: R. C. Rintoul, K. M. Skwarski, J. T. Murchison, W. A. Wallace, W. S. Walker, I. D. Penman
Journal: European Respiratory Journal (2005)

Accurate staging of the mediastinum in lung cancer is essential for optimising treatment strategies. Conventional transbronchial needle aspiration (TBNA) is a blind procedure, reliant upon prior computed tomography (CT) or ultrasound imaging, but has low sensitivity. The current study reports the initial experience of using a prototype endobronchial ultrasound (EBUS) probe that allows TBNA under real-time imaging. In 20 patients selected by CT scanning, a linear-array ultrasound bronchoscope was used to visualise paratracheal and hilar lymph nodes, and TBNA was performed under direct ultrasonic control. In seven cases, sequential endoscopic ultrasound (EUS) was used to assess postero-inferior mediastinal lymph nodes. All procedures were performed under conscious sedation. EBUS-TBNA was undertaken in 18 out of 20 cases and EUS-guided fine-needle aspiration in six out of seven cases. Cytology showed node (N)2/N3 disease in 11 out of 18 EBUS-TBNA cases and provided a primary diagnosis for eight patients. EBUS-TBNA cytology was negative in six cases, which was confirmed by mediastinoscopy or clinical follow-up in four. EUS provided additional information in all cases. There were no procedural complications. Sensitivity, specificity and accuracy for EBUS-TBNA were 85%, 100% and 89%, respectively. In conclusion, endobronchial ultrasound with real-time transbronchial needle aspiration offers improved sensitivity and accuracy for staging of the middle mediastinum, and, combined with endoscopic ultrasound, should allow investigation of the majority of the mediastinum.
Identification of p100 target promoters by chromatin immunoprecipitation-guided ligation and selection (ChIP-GLAS)
Authors: Xin Liu, Lijie Dong, Xuejun Zhang, Baoya Wang, Xinting Wang, Hu Li, Jinyan He, Lin Ge, Xiang Jing, Zhi Yao, Jie Yang
Journal: Cellular and Molecular Immunology (2010)
Bronchoalveolar Lavage–Directed Therapy in Children With Cystic Fibrosis and &lt;emph type="ital"&gt;Pseudomonas aeruginosa&lt;/emph&gt; Infection
Authors: Barry Linnane
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCT-120 Need for Permanent Pacemaker Following Implantation of the Repositionable Second-Generation LOTUS(tm) Device for Transcatheter Aortic Valve Replacement: Results From the Pivotal REPRISE II Trial
Authors: Nicolas Dumonteil, Ian T. Meredith, Darren L. Walters, Stephen G. Worthley, Didier Tchetche, Ganesh Manoharan, Daniel J. Blackman, Gilles Rioufol, David Hildick-Smith, Dominic J. Allocco, Keith D. Dawkins
Journal: Journal of the American College of Cardiology (2013)
Long-term outcome after severe head injury.
Authors: W Lewin, T F Marshall, A H Roberts
Journal: BMJ (1979)

From a consecutive series of 7000 patients with head injuries admitted to the regional accident service, Radcliffe Infirmary, Oxford between 10 and 24 years earlier, every patient was taken who had been amnesic or unconscious for one week or longer. Of these 479 patients, all but ten were traced, and either the cause of death was established or the survivors examined. Ten years after injury 4% were totally disabled, and 14% severely disabled to a degree precluding normal occupational or social life. Of the remainder, 49% had recovered, and the rest were dead. Additionally, a selected series of 64 patients whose unconsciousness had been prolonged for a month or more were studied. Forty of these had survived between three and 25 years after injury and were re-examined. On the basis of age at injury, the worst state of neurological responsiveness, and the duration of posttraumatic amnesia, the outcome of head injury can be predicted reliably in most cases. Patients and relatives need more reassurance and simple psychotherapeutic support, especially in the first few months after injury. Extrapolation from our figures suggests that each year in England and Wales 210 patients survive totally disabled and another 1500 are severely disabled.