Sex Differences in HIV-1 Viral Load Due to Sex Difference in <i>CCR5</i> Expression
Authors: Pierre Portales, Jacques Clot, Pierre Corbeau
Journal: Annals of Internal Medicine (2001)

Letters2 January 2001Sex Differences in HIV-1 Viral Load Due to Sex Difference in CCR5 ExpressionPierre Portales, DPharm, Jacques Clot, MD, PhD, and Pierre Corbeau, MD, PhDPierre Portales, DPharmHôpital Saint Eloi; Montpellier Cedex 5, France (Portales, Clot, Corbeau)Search for more papers by this author, Jacques Clot, MD, PhDHôpital Saint Eloi; Montpellier Cedex 5, France (Portales, Clot, Corbeau)Search for more papers by this author, and Pierre Corbeau, MD, PhDHôpital Saint Eloi; Montpellier Cedex 5, France (Portales, Clot, Corbeau)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-1-200101020-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Farzadegan and colleagues recently reported a sex difference in serum HIV-1 RNA levels (1). Their results corroborate previous studies showing that mean viral loads are about 50% lower in women than in men. The reason for this difference remains unclear.Membrane density in the main co-receptor CCR5 determines the in vitro infectability of a target cell by an HIV-1 R5 strain (2). Accordingly, we recently showed that CD4+ cell surface CCR5 density correlates with viral load in HIV-1–infected patients (3). In the same study, we also provided evidence that this density was unmodified by HIV-1 infection. Therefore, ...References1. Farzadegan H, Hoover DR, Astemborski J, Lyles CM, Margolick JB, Markham RB, et al . Sex differences in HIV-1 viral load and progression to AIDS. Lancet. 1998;352:1510-4. CrossrefMedlineGoogle Scholar2. Platt EJ, Wehrly K, Kuhmann SE, Chesebro B, Kabat D. Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1. J Virol. 1998;72:2855-64. CrossrefMedlineGoogle Scholar3. Reynes J, Portales P, Segondy M, Baillat V, Andre P, Reant B, et al . CD4+ T cell surface CCR5 density as a determining factor of virus load in persons infected with human immunodeficiency virus type 1. J Infect Dis. 2000;181:927-32. CrossrefMedlineGoogle Scholar4. Vassiliadou N, Tucker L, Anderson DJ. Progesterone-induced inhibition of chemokine receptor expression on peripheral blood mononuclear cells correlates with reduced HIV-1 infectability in vitro. J Immunol. 1999;162:7510-8. MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Hôpital Saint Eloi; Montpellier Cedex 5, France (Portales, Clot, Corbeau) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoInflation of Precision in Medical Reports Glen L. Hortin Metrics Cited BySexual role and HIV-1 set point viral load among men who have sex with menDifferential effects of sex in a West African cohort of HIV-1, HIV-2 and HIV-1/2 dually infected patients: men are worse offCCR5 Expression Is Reduced in Lymph Nodes of HIV Type 1-Infected Women, Compared With Men, But Does Not Mediate Sex-Based Differences in Viral LoadsSerum concentrations of antiphospholipid and anticardiolipin antibodies are higher in HIV-infected womenGender Specific Differences in the Immune Response to InfectionImmune reconstitution under antiretroviral therapy: the new challenge in HIV-1 infectionFactor VIII concentration is greater in female than male patients with HIV infectionMendelian randomization: potential use of genetics to enable causal inferences regarding HIV-associated biomarkers and outcomesSex-specific differences in treatment outcomes for patients with HIV and AIDSFactors impacting the expression of membrane-bound proteins in lymphocytes from HIV-positive subjectsPredominant type 1 CMV-Specific memory T-helper response in humans: evidence for gender differences in cytokine secretionDoes Patient Sex Affect Human Immunodeficiency Virus Levels?Inflation of Precision in Medical ReportsGlen L. Hortin, MD, PhD 2 January 2001Volume 134, Issue 1Page: 81-82KeywordsBlood cellsCell membranesHIV-1ProgesteroneRNAT cellsViral load ePublished: 2 January 2001 Issue Published: 2 January 2001 CopyrightCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...