Pathogenesis of Congestive Heart Failure
Authors: LLOYD T. ISERI
Journal: Annals of Internal Medicine (1963)

Article1 December 1963Pathogenesis of Congestive Heart FailureCorrelation Between Anaerobic Metabolism and Plasma Volume Changes Following ExerciseLLOYD T. ISERI, M.D., F.A.C.P., JOHN R. EVANS, M.D., MICHAEL EVANS, B.A.LLOYD T. ISERI, M.D., F.A.C.P.Search for more papers by this author, JOHN R. EVANS, M.D.Search for more papers by this author, MICHAEL EVANS, B.A.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-6-788 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has been stated frequently that congestive heart failure occurs when cardiac output is not sufficient enough to meet the "metabolic needs" of the body. What these "metabolic needs" are and how inability to meet these needs causes fluid and sodium retention in cardiac patients have not been elucidated.Huckabee and Judson (1) recently showed that symptomatic cardiac patients subjected to mild exercise demonstrated an increase in the rate of anaerobic metabolism. Asymptomatic patients revealed no such increase. Donald and associates (2) found that increased lactic acid production (that is, increased anaerobic metabolism) by cardiac patients during exercise was related...References1. HUCKABEEJUDSON WEWE: The role of anaerobic metabolism in the performance of mild muscular work. I. Relationship to oxygen consumption and cardiac output and the effect of congestive heart failure. J. Clin. Invest. 37: 1577, 1958. CrossrefMedlineGoogle Scholar2. DONALDGLOSTERHARRISREEVESHARRIS KWJEAJP: The production of lactic acid during exercise in normal subjects and in patients with rheumatic heart disease. Amer. Heart J., 62: 494, 1961. 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DEYRUP I: A study of the fluid uptake of rat kidney slices in vitro. J. Gen. Physiol. 36: 739, 1953. CrossrefMedlineGoogle Scholar20. LEAF A: On the mechanism of fluid exchange of tissues in vitro. Biochem. J. 62: 241, 1956. CrossrefMedlineGoogle Scholar21. HANNONCOOK JPSF: Effects of anoxia on the respiratory and water metabolism of mouse diaphragm. Amer. J. Physiol. 187: 155, 1956. CrossrefMedlineGoogle Scholar22. VERNEY EB: Croonian Lecture. The antidiuretic hormone and the factors which determine its release. Proc. Roy. Soc. Med. 135: 25, 1947. Google Scholar23. DENINGLEUTSCHER QBJA: Bioassay of desoxycorticosterone-like material in urine. Proc. Soc. Exp. Biol. Med. 73: 171, 1950. CrossrefGoogle Scholar24. DAVIS JC: Adrenocortical and renal hormonal function in experimental cardiac failure. Circulation 25: 1002, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Downey and Los Angeles, CaliforniaFrom Medical Science Service, Rancho Los Amigos Hospital, Downey, California, and Departments of Internal Medicine, Loma Linda University School of Medicine and California College of Medicine, Los Angeles, California.The work was supported in part by research grant H-3987 from the National Heart Institute, United States Public Health Service, and by the American Heart Association.Requests for reprints should be addressed to Lloyd T. Iseri, M.D., Medical Science Service, Rancho Los Amigos Hospital, 7601 East Imperial Highway, Downey, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPathogenesis and management of congestive heart failure—revisitedREFERENCESMetabolic and hemodynamic responses to exercise during atrial fibrillation and sinus rhythmCardiovascular problems and functional evaluation in rehabilitation of hemiplegic patientsAcidosi latticaAnaerobic metabolic responses to acute maximal exercise in male athletes 1 December 1963Volume 59, Issue 6Page: 788-797KeywordsBlood plasmaExerciseHeartHeart failureHospital medicineLactic acidMedical servicesPathogenesisResearch grantsSodium Issue Published: 1 December 1963 PDF DownloadLoading ...