tbuckley/cabot-search huggingface dataset:
Serum IgM testing is needed in all cases of suspected measles
Authors: M Ramsay, B Cohen, D Brown
Journal: BMJ (1996)

Serum IgM testing is needed in all cases of suspected measles EDiTOR,-We agree with Laura Ryall and colleagues that testing for virus specific IgM, in either a saliva specimen or a serum sample, is the appropriate initial method for diagnosing measles.'The main advantage of IgM testing, given the current epidemiology of measles in England and Wales, is its high specificity.Currently measles infections are rare, and less than 1% of notified cases have been confirmed by IgM assay of saliva in the past six months.2In this context, even a test that was 99% specific would be expected to have a positive predictive value of around 50%: for every 1000 suspected cases tested there will be about 10 false positive and 10 true positive results.Since 1995, therefore, the Public Health Laboratory Service Communicable Disease Surveillance Centre has requested additional tests on all cases of labora- tory confirmed measles reported in England and Wales.The reporting doctor or laboratory has been asked to refer a serum specimen for IgM assay, either to a local laboratory or to the Public Health Laboratory Service Enteric and Respiratory Virus Laboratory.Table 1-Cases of measles reported to Comtnuni- cable Disease Surveillance Centre by method of diagnosis Serum measles IgM result Initial method of No No No (%) diagnosis reported tested positive Single high IgG in CFT 46 31 13 (42) Fourfold rise in IgG in CFT 12 8 3 (38) Salivary IgM test 38 12 8 (67) Serum IgM test* 11 8 5 (75) Total 107 59 29 (49) CFT = complement fixation test.Reports of cases that were positive on IgM testing by ELISA and were retested with an IgM antibody capture radio- immunoassay.
Rhymes to Meet Snakes By-Reply
Authors: Craig S. Kitchens
Journal: JAMA (1988)

<h3>In Reply.</h3> —We, too, are aware of the dictum mentioned by Drs Murray and Wurstlin. Nearly everyone in the area where coral snakes are endemic is aware of the dictum or modifications thereof. However, it has not proved to prevent victims from being bitten by the snake. We offer two explanations for this failure: (1) often patients are inebriated and don't seem to remember the rhyme correctly and (2) often it becomes altered to something like "Red on yellow, friend of a fellow/Red on black will kill Jack." Our experience, then, is that the dictum or at least the reciting of it at the time of confrontation with a snake is imperfect. Accordingly, we advise people to avoid any snake that looks like either of these reptiles.
An evaluation of the beta‐1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT‐HF sub‐study
Authors: Hazel L. White, Rudolf A. de Boer, Azhar Maqbool, Darren Greenwood, Dirk J. van Veldhuisen, Richard Cuthbert, Stephen G. Ball, Alistair S. Hall, Anthony J. Balmforth
Journal: European Journal of Heart Failure (2003)
Immunohistochemical localization of granzyme B in peritumoral infiltrates of basal cell carcinoma
Authors: M.E.J.M. Verhaegh, P.C. Wever, H.A.M. Neumann, R. Hoekzema
Journal: British Journal of Dermatology (1997)

Journal Article Immunohistochemical localization of granzyme B in peritumoral infiltrates of basal cell carcinoma Get access M.E.J.M. Verhaegh, M.E.J.M. Verhaegh Department of Dermatology, University Hospital Maastricht, Maastricht, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar P.C. Wever, P.C. Wever Renal Transplant Unit AMC, University of Amsterdam, Amsterdam, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar H.A.M. Neumann, H.A.M. Neumann Department of Dermatology, University Hospital Maastricht, Maastricht, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar R. Hoekzema R. Hoekzema Department of Dermatology, University Hospital Maastricht, Maastricht, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 137, Issue 6, 1 December 1997, Pages 1012–1014, https://doi.org/10.1111/j.1365-2133.1997.tb01571.x Published: 01 December 1997
Rapid diagnosis of coronary reperfusion by measurement of myoglobin level every 15 min in acute myocardial infarction
Authors: Masaaki Miyata, Satoshi Abe, Shinichi Arima, Kunihiro Nomoto, Masamitsu Kawataki, Makoto Ueno, Tsuminori Yamashita, Shuichi Hamasaki, Hitoshi Toda, Minoru Tahara, Yoshihiko Atsuchi, Shoichiro Nakao, Hiromitsu Tanaka
Journal: Journal of the American College of Cardiology (1994)
Lack of women cardiologists might lower standards
Authors: Roger Dobson
Journal: BMJ (2005)

Women are rejecting cardiology as a career because of long working hours, lack of flexible training and part time consultant posts, and an absence of role models.

If more women are not attracted to the discipline, standards may fall, warns a report from a working group of the British Cardiac Society. The report makes a series of recommendations and promises tough action on any cases of sexism.

The working group …
Women, Men, and Examination Scores
Authors: Marjorie A. Bowman, Timothy P. Foley
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 May 1985Women, Men, and Examination ScoresMARJORIE A. BOWMAN, M.D.M.P.A., TIMOTHY P. FOLEY, M.A.MARJORIE A. BOWMAN, M.D.M.P.A.Search for more papers by this author, TIMOTHY P. FOLEY, M.A.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-5-725 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We are pleased to see research on the performance of female physicians, an area of much interest yet insufficient understanding. The article by Dr. Norcini and colleagues (1) raises as many questions as it answers, however.The data indicate that very little or none of the variation in scores could be attributed to sex. The authors found that 0.5% of R2in 1982 was uniquely contributed by sex. Thus, confounding factors must have been overlooked in accounting for the difference between the performances of men and women. The authors suggest that some convergence of the scores is...References1. NORCINIFLETCHERQUIMBYSHEA JSBJ. Performance of women candidates on the American Board of Internal Medicine certifying examination, 1973-1982. Ann Intern Med. 1985;102:115-8. LinkGoogle Scholar2. GORDONJOHNSON TD. Study of U. S. medical school applicants. J Med Educ. 1978;53:873-97. MedlineGoogle Scholar3. DEAUX K. From individual differences to social categories: an analysis of a decade's research on gender. Am Psychol. 1984;39:105-16. CrossrefGoogle Scholar1. GORDON T. Study of U. S. medical school applicants. J Med Educ. 1978;53:873-97. MedlineGoogle Scholar2. DEAUX K. From individual differences to social categories: an analysis of a decade's research on gender. Am Psychol. 1984;39:105-16. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1985Volume 102, Issue 5Page: 725-726 Issue Published: 1 May 1985 PDF downloadLoading ...
P3-154: Dynamic contrast–enhanced (DCE) MRI imaging biomarker in Phase I study with imatinib (I) and cisplatin (C) plus docetaxel (D) in patients with advanced non–small cell lung cancer (NSCLC)
Authors: Gordana Vlahovic, Benjamin Viglianti, Traci L. Foster, Carolyn H. Andrews, James E. Herndon, Thomas Sporn, Michael J. Kelley, Mark W. Dewhirst, Zeljko Vujaskovic
Journal: Journal of Thoracic Oncology (2007)
Developing a hospital information strategy.
Authors: E. J. Acheson, L. Cotter
Journal: BMJ (1992)

The NHS nursing home experiments showed that high quality nursing home care is no cheaper than traditional NHS continuing care.3Furthermore, a recent report by the Social Security Committee highlighted the underfunding of fees for state supported nursing homes.4Before pro- vision of NHS continuing care is considerably reduced the Department of Health must ensure that the need for high quality care for dependent elderly people is being met elsewhere.At present the NHS is still committed to looking after those requiring "nursing care," and many of the highly dependent and their families continue to request this.5Much could be learnt from the experience of other countries (for example, Australia), but so far the policy makers have seemed to ignore this, with the resultant present chaos.A cohesive national policy is needed, but evidence suggests that the muddle will continue (or increase) after the water- shed for community care in April next year.
Getting Together in Kansas—An Example to Emulate
Authors: S. J. Crumbine
Journal: JAMA (1913)

<h3>To the Editor</h3> —At the spring meeting of the medical society of a certain county in southwest Kansas, suggestion was made that one of the members of the society should be a candidate for the legislature, in order that the interests of physicians might be safeguarded by representatives from among the profession. This was determined because the interests of physicians were menaced by the last legislature and were also seriously threatened through the activities of the chiropractors and the League for Medical Freedom in the legislature which was to be chosen and is now in session. After considerable discussion, it was decided that Dr. R. T. Nichols of Liberal (the county seat) should be the person to make the race. Dr. Nichols' popularity among the people had been attested by the fact of his election as mayor, and lie had shown marked executive ability as well as much forcefulness of character
Late Mortality Among 5-Year Survivors of Childhood Cancer: A Summary From the Childhood Cancer Survivor Study
Authors: Gregory T. Armstrong, Qi Liu, Yutaka Yasui, Joseph P. Neglia, Wendy Leisenring, Leslie L. Robison, Ann C. Mertens
Journal: Journal of Clinical Oncology (2009)

The Childhood Cancer Survivor Study (CCSS) has assembled the largest cohort to date for assessment of late mortality. Vital status and cause of death of all patients eligible for participation in CCSS was determined using the National Death Index and death certificates to characterize the mortality experience of 20,483 survivors, representing 337,334 person-years of observation. A total of 2,821 deaths have occurred as of December 31, 2002. The overall cumulative mortality is 18.1% (95% CI, 17.3 to 18.9) at 30 years from diagnosis. With time, while all-cause mortality rates have been stable, the pattern of late death is changing. Mortality attributable to recurrence or progression of primary disease is decreasing, with increases in rates of mortality attributable to subsequent neoplasms (standardized mortality ratios [SMR], 15.2; 95% CI, 13.9 to 16.6), cardiac death (SMR, 7.0; 95% CI, 5.9 to 8.2), and pulmonary death (SMR, 8.8; 95% CI, 6.8 to 11.2) largely due to treatment-related causes. In addition, the CCSS has identified specific treatment-related risk factors for late mortality. Radiotherapy (relative risk [RR], 2.9; 95% CI, 2.1 to 4.2), alkylating agents (RR, 2.2; 95% CI, 1.6 to 3.0), and epipodophyllotoxins (RR, 2.3; 95% CI, 1.2 to 4.5) increase the risk of death due to subsequent malignancy. Cardiac radiation exposure (RR, 3.3; 95% CI, 2.0 to 5.5) and high dose of anthracycline exposure (RR, 3.1; 95% CI, 1.6 to 5.8) are associated with late cardiac death. By continued longitudinal follow-up of the cohort and expansion of the cohort to include patients diagnosed between 1987 and 1999, the CCSS will remain a primary resource for assessment of late mortality of survivors of childhood cancers.
The fractalkine receptor CX3CR1 is involved in liver fibrosis due to chronic hepatitis C infection
Authors: Hermann E. Wasmuth, Mirko Moreno Zaldivar, Marie-Luise Berres, Alexa Werth, David Scholten, Sonja Hillebrandt, Frank Tacke, Petra Schmitz, Edgar Dahl, Tonio Wiederholt, Claus Hellerbrand, Thomas Berg, Ralf Weiskirchen, Christian Trautwein, Frank Lammert
Journal: Journal of Hepatology (2007)
Studies of the Philadelphia Chromosome.
Authors: K. O. Goh
Journal: Annals of Internal Medicine (1964)

s1 April 1964Studies of the Philadelphia Chromosome.K. O. Goh, M.D., S. N. Swisher, M.D., F.A.C.P.K. O. Goh, M.D.Search for more papers by this author, S. N. Swisher, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-729_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn abnormal chromosome called "Philadelphia" or Ph1has been demonstrated in the metaphase nuclei of hematopoietic cells of patients with chronic myelocytic leukemia. This chromosome has been identified in all of the 20 patients with chronic myelocytic leukemia. This chromosome has been identified in all of 20 patients with chronic myelocytic leukemia in various stages of the disease studied in this clinic. This abnormal chromosome was not found in 9 patients with myeloid metaplasia showing various clinical and hematological manifestations, including high or low values of leukocyte alkaline phosphatase. The Ph1was not found in a normal identical twin of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByChromosomal Changes in Human Tumors and LeukemiasCytogenetic Studies in Eosinophilic Leukemia The Relationship of Eosinophilic Leukemia and Chronic Myelocytic LeukemiaKONG-OO GOH, M.D., SCOTT N. SWISHER, M.D., CHARLES A. ROSENBERG, M.D. 1 April 1964Volume 60, Issue 4Page: 729-730KeywordsCellsChromosomal diseasesChromosomesChronic myelocytic leukemiaHematology and oncologyMonozygotic twinsPhosphatases Issue Published: 1 April 1964 PDF DownloadLoading ...
Impact of Physician's Assistants on Patient Visits in Ambulatory Care Practices
Authors: EUGENE C. NELSON
Journal: Annals of Internal Medicine (1975)

The addition of a physician's assistant to an ambulatory care practice increases the practice's productivity. Practices using physician's assistants (medexes) had a 12% increase in the number of patient visits during the first year of training and 1¾ years later had an average increase of 37%. The medex by himself provided care to 28% of the patients and, in company with the physician, to another 10%. No consistent changes across practices were noted in patient waiting times or time physicians spend with patients.
The Retrieval of Medical Literature
Authors: David S. Channin
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Although full-text medical literature retrieval by computer, as described by Drs Collen and Flagle,<sup>1</sup>is a welcome addition to medical informatics, there are several problems that should be nipped in the bud. Mostly, these involve the distinction between the terms<i>availability</i>of a data base and<i>distribution</i>of a data base. The concept of a large, central computer system, time-sharing to many remote users, directly contradicts the modern philosophy of distributed processing, ie, one person, one processor. On top of this, the drastic drop in the price of random access memory and the drop in price per megabyte of hard-disk subsystems are bringing the capacity to handle large data bases to the common user. While it is obvious that the entire MEDIS data base could not be managed by a microcomputer, and while hard-disk subsystems and large-system memories are not ubiquitous yet, it is clear that
Over 300 million children chronically malnourished
Authors: John Zarocostas
Journal: BMJ (2006)

<h3>Abstract</h3> Degradation of intrinsically disordered proteins (IDPs) by the 20S proteasome, unlike ubiquitin-dependent 26S proteasomal degradation, does not require proteasomal targeting by polyubiquitin. However, how these proteins are recognized by the proteasome was unknown. We report here on a mechanism of 20S proteasome targeting. Analysis of protein interactome datasets revealed that the proteasome subunit PSMA3 interacts with many IDPs. By employing in vivo and cell-free experiments we demonstrated that the PSMA3 C-terminus binds p21, c-Fos and p53, all IDPs and 20S proteasome substrates. A 69 amino-acids long fragment is autonomously functional in interacting with IDP substrates. Remarkably, this fragment in isolation blocks the degradation of a large number of IDPs in vitro and increases the half-life of proteins in vivo. We propose a model whereby the PSMA3 C-terminal region plays a role of substrate receptor in the process of proteasomal degradation of many IDPs.
How does endoscopic sclerotherapy alter splanchnic hemodynamics? Bourbon P, Zarski JP, Kitmacher P, Bourlard P, Machecourt J, Denis B, Rachail M. Esophageal varice sclerotherapy: influence on portal pressure and azygos blood flow. Gastroenterol Clin Biol 1990;14:244–247
Authors: P Calès
Journal: Hepatology (1991)
The 1,2,3,4 phenomenon. Atrioventricular nodal gap in the dog.
Authors: A R Ticzon, A N Damato, A R Caracta, S H Lau, G A Bobb
Journal: Circulation Research (1976)

This study confirms the facility with which the so-called 1,2,3,4 phenomenon can be reproduced in intact dog hearts. When a series of three atrial premature beats (A2, A3, A4) were delivered following a constant A1-A1 drive, we demonstrated a narrow zone of A1-A3 and A1-A4 intervals in which A4 conducted to the ventricles in the presence of A3 but not in its absence. We used His bundle and multiple atrial electrograms to produce the phenomenon in nine of 16 dogs. Facilitation of conduction of A4 (1) occurred above the His bundle, (2) occurred within narrow ranges of A1-A3 and A1-A4 intervals, (3) required penetration of A3 into the atrioventricular (AV) node, (4) required critically long A2-H2 intervals, (5) always was associated with prolonged A4-H4 intervals, and (6) was limited by atrial refractoriness. An apparent or pseudo-1,2,3,4 phenomenon demostrated in five of 16 dogs occurred with (1) latency between S4 and A4, (2) a sinus nodal or atrial reentry beat, or (3) an atrial escape beat. In the absence of A3, A4 could be made to conduct by preexciting the ventricle in advance of V2. We found no evidence for dual AV nodal pathways. Our results suggest that the underlying mechanism for the 1,2,3,4 phenomenon is analogous to the phenomenon of the gap in AV conduction.
Neutralizing antiidiotypic antibodies to factor VIII inhibitors after desensitization in patients with hemophilia A.
Authors: J G Gilles, B Desqueper, H Lenk, J Vermylen, J M Saint-Remy
Journal: Journal of Clinical Investigation (1996)

Hemophilia A patients producing antibodies towards FVIII are usually treated with infusions of high doses of FVIII in an attempt to "desensitize" them. To examine the mechanisms by which such desensitization operates, sequential plasma samples of two unrelated inhibitor patients were analyzed for anti-FVIII and antiidiotypic antibodies before and during infusions of high doses of FVIII. Anti-FVIII antibodies were separated from antiidiotypic antibodies by immunoaffinity chromatography before analysis. We show in the present study that the concentration of anti-FVIII antibodies did not change during a successful desensitization and that antibodies maintained their capacity to inhibit the procoagulant function of FVIII, even though the number of Bethesda units in plasma was reduced to undetectable levels. Using a competition assay with mAbs, we further show that the specificity of human antibodies did not vary significantly during therapy. Finally, we show that the treatment elicited antiidiotypic antibodies, which neutralized the inhibitory capacity of anti-FVIII antibodies. Inhibitor antibodies can therefore not be accurately evaluated in plasma, as their function appears to be neutralized by antiidiotypic antibodies. These findings could have implications for the design of new therapies for hemophilia A patients with inhibitors.
T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells
Authors: Martijn L. Bakker, Gerard J.J. Boink, Bas J. Boukens, Arie O. Verkerk, Malou van den Boogaard, A. Denise den Haan, Willem M.H. Hoogaars, Henk P. Buermans, Jacques M.T. de Bakker, Jurgen Seppen, Hanno L. Tan, Antoon F.M. Moorman, Peter A.C. 't Hoen, Vincent M. Christoffels
Journal: Cardiovascular Research (2012)

Treatment of disorders of the sinus node or the atrioventricular node requires insights into the molecular mechanisms of development and homoeostasis of these pacemaker tissues. In the developing heart, transcription factor TBX3 is required for pacemaker and conduction system development. Here, we explore the role of TBX3 in the adult heart and investigate whether TBX3 is able to reprogramme terminally differentiated working cardiomyocytes into pacemaker cells.TBX3 expression was ectopically induced in cardiomyocytes of adult transgenic mice using tamoxifen. Expression analysis revealed an efficient switch from the working myocardial expression profile to that of the pacemaker myocardium. This included suppression of genes encoding gap junction subunits (Cx40, Cx43), the cardiac Na(+) channel (Na(V)1.5; I(Na)), and inwardly rectifying K(+) ion channels (K(ir) genes; I(K1)). Concordantly, we observed conduction slowing in these hearts and reductions in I(Na) and I(K1) in cardiomyocytes isolated from these hearts. The reduction in I(K1) resulted in a more depolarized maximum diastolic potential, thus enabling spontaneous diastolic depolarization. Neither ectopic pacemaker activity nor pacemaker current I(f) was observed. Lentiviral expression of TBX3 in ventricular cardiomyocytes resulted in conduction slowing and development of heterogeneous phenotypes, including depolarized and spontaneously active cardiomyocytes.TBX3 reprogrammes terminally differentiated working cardiomyocytes and induces important pacemaker properties. The ability of TBX3 to reduce intercellular coupling to overcome current-to-load mismatch and the ability to reduce I(K1) density to enable diastolic depolarization are promising TBX3 characteristics that may facilitate biological pacemaker formation strategies.
THE PRESENT STATUS OF PLASMA EXPANDERS
Authors: Frank W. Hartman
Journal: JAMA (1953)

The term  substitute, used extensively during World War I and at the beginning of World War II, has been abandoned, since it is agreed that there is no real substitute for blood either in content or in function. In addition, the use of this term is misleading, especially to the public, raising the question as to the necessity for contributions of blood for military and civil defense use or even for friends and relatives. Actually there is no substitute for blood plasma, but certain macromolecular colloidal solutions possessing some of the physical properties of  are capable of maintaining the circulating blood volume by virtue of their oncotic pressure, which attracts interstitial fluids into the blood vascular system. The large molecular size prevents their rapid escape into the tissues or through the kidneys until the blood volume has been restored to normal. The term plasma expander is now used