tbuckley/cabot-search huggingface dataset:
Red in the face
Authors: J. Hafiji, J. Batchelor
Journal: BMJ (2010)

A 76 year old woman with metastatic neuroendocrine carcinoma underwent laparotomy and ileocolic resection for small bowel obstruction. The postoperative course was complicated by an anastomotic leak so she returned to theatre for refashioning of the ileostomy. While recovering on the ward, she developed a grade IV sacral sore and the laparotomy wound became infected with meticillin resistant Staphylococcus aureus (MRSA).

The organism was found to be sensitive to doxycycline, which was therefore started orally. The laparotomy wound began to heal well after three weeks of treatment. The patient however, developed a burning tingling rash on the left side of her face (figure⇓), which was warm and tender to touch. She remained systemically well with no fever, facial swelling, or regional lymphadenopathy. She had no history of skin disease.





### 1 How would you describe the physical signs?

#### Short answer

A florid eruption composed of a sharply demarcated erythematous macular patch on the left side of her face with complete sparing of the contralateral side.

#### Long answer

The term macule describes a well circumscribed flat alteration in the colour of the skin, less than 1 cm in diameter. It may be coloured—for example, pink or red owing to vasodilation and mild inflammatory changes; purple or yellow-brown from blood or haemosiderin; or brown, black, pale, or white owing to a disturbance in melanin synthesis. A patch is a flat lesion greater than 1 cm in diameter (a large macule), as …
Flow cytometric analysis of T and Tn epitopes on chronic lymphocytic leukemia cells
Authors: Cynthia Timlick Aller, Omer Kucuk, Georg F. Springer, Alice Gilman-Sachs
Journal: American Journal of Hematology (1996)

Immunophenotyping of peripheral blood lymphocytes from six patients with B-cell chronic lymphocytic leukemia (B-CLL) and five normal volunteers was done and their T and Tn epitopes analyzed using specific monoclonal antibodies and flow cytometry. Lymphocytes from all patients showed strong Tn expression as compared to normal control lymphocytes. By contrast, T antigen was not expressed. The Tn expression may be a useful diagnostic and prognostic marker for B-CLL. © 1996 Wiley-Liss, Inc.
Intralesional therapy of cutaneous leishmaniasis with sodium stibogluconate antimony
Authors: K.E. SHARQUIE, K.K. AL-TALIB, A.C. CHU
Journal: British Journal of Dermatology (1988)

Journal Article Intralesional therapy of cutaneous leishmaniasis with sodium stibogluconate antimony Get access K.E. SHARQUIE, K.E. SHARQUIE Department of Dermatology, College of Medicine, University of Baghdad, Iraq Search for other works by this author on: Oxford Academic Google Scholar K.K. AL‐TALIB, K.K. AL‐TALIB Department of Dermatology, College of Medicine, University of Baghdad, IraqDermatology Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K. Dr K.K.Al‐Talib, Dermatology Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London W120HS, U.K. Search for other works by this author on: Oxford Academic Google Scholar A.C. CHU A.C. CHU Dermatology Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 119, Issue 1, 1 July 1988, Pages 53–57, https://doi.org/10.1111/j.1365-2133.1988.tb07100.x Published: 01 July 1988
Altering Retroviral Tropism Using a Random-Display Envelope Library
Authors: Keith Bupp, Monica J Roth
Journal: Molecular Therapy (2002)

Tissue-specific gene delivery is an important aspect of many gene therapy applications. The experiments reported here constitute the first successful demonstration that cell-specific entry can be obtained by screening a random library of retroviral envelope proteins produced from a mammalian cell system. The library consisted of 106 different subgroup A feline leukemia virus envelope protein variants with 10 randomly substituted amino acids in the receptor-determining region. Selecting the library for fully functional envelope proteins able to mediate stable gene transfer resulted in the identification of a single envelope protein variant (EF). Subsequent examination of the host range of EF revealed that it was highly specific for D17 canine osteosarcoma cells. This was in contrast to the host ranges of the parental subgroup A and closely related subgroup C envelope proteins. Interference assays on D17 cells further indicated that receptor usage by EF was also altered compared with the A and C envelope proteins. The EF envelope protein thus isolated should be useful for studying gene therapy treatments of osteosarcoma in a large-animal model.
Imipramine Treatment of Painful Diabetic Neuropathy
Authors: Birgit Kvinesdal
Journal: JAMA (1984)

Twelve patients with severe, painful diabetic neuropathy in the lower extremities were treated with imipramine and placebo in a fixed-dose, double-blind, crossover study of five plus five weeks. Seven patients experienced notable improvement while receiving imipramine and none while receiving placebo. The rating of specific symptoms at the end of each treatment period showed a beneficial effect of imipramine on pain, paresthesia, dysesthesia, numbness, and nocturnal aggravation. The plasma levels of imipramine and its metabolite desipramine were significantly higher in patients who benefited from imipramine treatment.
Antibodies to Human T-Lymphotropic Virus Type III and Development of the Acquired Immunodeficiency Syndrome in Homosexual Men Presenting with Immune Thrombocytopenia
Authors: DONALD I. ABRAMS
Journal: Annals of Internal Medicine (1986)

In 35 homosexual men with isolated thrombocytopenia at initial presentation, who were evaluated and treated between 1982 and 1984, hematologic studies showed immune destruction. In contrast to findings in other autoimmune conditions, T-lymphocyte subsets in these patients were reversed, with a mean helper to suppressor ratio of 0.4 and with an absolute depletion of helper cells to 390/mm3. An enzyme-linked immunosorbent assay detected antibodies to human T-lymphotropic virus type III in 21 of 25 patients tested; Western blot analysis confirmed seropositivity in the other 4 patients, who had borderline findings. Although 19 of 24 patients treated with steroids responded, only 2 achieved sustained normal platelet counts. Ten of fifteen patients who had splenectomy achieved remissions. Three patients treated with steroids or splenectomy developed diagnoses compatible with the acquired immunodeficiency syndrome 16 to 34 months after their initial presentation with thrombocytopenia. These findings indicate that immune thrombocytopenia is part of the clinical spectrum of the acquired immunodeficiency syndrome.
Pulmonary Large Cell Carcinoma Mimicking an Infected Thoracoabdominal Aortic Aneurysm
Authors: Tetsuhiro Nakano, Kimihiro Shimizu, Toru Takahashi, Jun Mohara, Norimasa Koike, Osamu Kawashima, Mitsuhiro Kamiyoshihara, Masayuki Sugano, Takashi Ibe, Seiichi Kakegawa, Toshiteru Nagashima, Jun Atsumi, Izumi Takeyoshi
Journal: Journal of Thoracic Oncology (2011)
Peripheral nerve regeneration within an asymmetrically porous PLGA/Pluronic F127 nerve guide conduit
Authors: Se Heang Oh, Jun Ho Kim, Kyu Sang Song, Byeong Hwa Jeon, Jin Hwan Yoon, Tae Beom Seo, Uk Namgung, Il Woo Lee, Jin Ho Lee
Journal: Biomaterials (2007)
Dose-Dense Chemotherapy for Node-Positive Breast Cancer
Authors: Marc L. Citron
Journal: Annals of Internal Medicine (2005)

Letters1 February 2005Dose-Dense Chemotherapy for Node-Positive Breast CancerMarc L. Citron, MDMarc L. Citron, MDFrom Albert Einstein College of Medicine, Lake Success, NY 11042.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-3-200502010-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In the 2004 Update in Oncology (1), Dr. Steven H. Stein discussed a study by the U.S. Breast Cancer Intergroup on dose-dense therapy for node-positive breast cancer (2) and questioned the expense of filgrastim support. Dose-dense chemotherapy increases the dose intensity of the adjuvant regimen by delivering standard-dose chemotherapy with shorter intervals between the cycles. Filgrastim support enables the delivery of dose-dense chemotherapy and reduces the risk for neutropenia and its complications (3). Although the U.S. Breast Cancer Intergroup Trial C9741 acknowledged the added cost, concerns over the added expense must be weighed against the savings that ...References1. Stein SH. Update in oncology. Ann Intern Med. 2004;141:454-9. [PMID: 15381519] LinkGoogle Scholar2. Citron ML, Berry DA, Cirrincione C, Hudis C, Winer EP, Gradishar WJ, et al. Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741. J Clin Oncol. 2003;21:1431-9. [PMID: 12668651] MedlineGoogle Scholar3. Citron ML. Dose density in adjuvant chemotherapy for breast cancer. Cancer Invest. 2004;22:555-68. [PMID: 15565814] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Albert Einstein College of Medicine, Lake Success, NY 11042.Note: Dr. Citron is the principal investigator of the U.S. Breast Cancer Intergroup Trial C9741. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoUpdate in Oncology Steven H. Stein Metrics Cited ByA Neoadjuvant Chemotherapy Trial for Early Breast Cancer is Impacted by COVID-19: Addressing Vaccination and Cancer Trials Through Education, Equity, and OutcomesAdjuvant Chemotherapy for Early Breast Cancer in the ElderlyCarboplatin plus Gemcitabine Repeating Doublet Therapy in Recurrent Breast CancerSafety and efficacy of once-per-cycle pegfilgrastim in support of ABVD chemotherapy in patients with Hodgkin lymphoma 1 February 2005Volume 142, Issue 3Page: 227KeywordsBreast cancerCancer treatmentChemotherapyForecastingHospitalizationsNeutropenia ePublished: 1 February 2005 Issue Published: 1 February 2005 CopyrightCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Gsα Deficiency in Adipose Tissue Leads to a Lean Phenotype with Divergent Effects on Cold Tolerance and Diet-Induced Thermogenesis
Authors: Min Chen, Hui Chen, Annie Nguyen, Divakar Gupta, Jie Wang, Edwin W. Lai, Karel Pacak, Oksana Gavrilova, Michael J. Quon, Lee S. Weinstein
Journal: Cell Metabolism (2010)
Antiherpes Drug May Suppress HIV Levels
Authors: Tracy Hampton
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Irreducible Femoral Hernia: Operation: Recovery
Authors: C. F. Maunder
Journal: BMJ (1876)

My patient had suffered from ague twenty-three years previously to the commencement of the attack of antemia which proved fatal.He also came from a district in Cambridgeshire in which ague used to prevail, but in which it is now almost unknown.It is highly impro- bable, therefore, that exposure to paludal miasma was the cause of his illness.The bloodl had not the appearance described by Eichhorst as cha.racteristic of this affection, as I have stated in the notes.Dr. Grainger Stewart lias failed to discover these appearances in two weli marked and ultlimately fatal cases which occurred in his practice (BRITISH MEDICAL JOURNAL, July Sth, i876).In some cases of this disease, fatty degeneration of the heart has been observed; but, in my case, the heart was somewhat hypertrophied and the muscular * Read before the conjoint meeting at Rochester of the East and West Kent Districts of the South-Eastern Branch.
Formoterol, a new long acting beta 2 agonist for inhalation twice daily, compared with salbutamol in the treatment of asthma.
Authors: A Wallin, B Melander, L Rosenhall, T Sandstrom, L Wahlander
Journal: Thorax (1990)

Sixteen patients with stable chronic asthma participated in a double blind crossover study comparing the new inhaled long acting beta 2 agonist formoterol with salbutamol. Inhaled (n = 15) and oral steroid (n = 1) treatment were maintained at the same daily dose throughout the study. For four weeks the patients received either formoterol 24 micrograms twice daily or salbutamol 400 micrograms twice daily, plus additional puffs (with the same drug) when needed. Asthma symptoms, additional puffs of beta 2 agonist, peak expiratory flow (PEF), and side effects were recorded daily. During treatment with formoterol the patients used fewer additional puffs of beta 2 agonist, had better symptom scores, less disturbed sleep, more days without additional aerosol, and higher PEF both morning and evening than during salbutamol treatment. Thus formoterol 24 micrograms twice daily gave long lasting bronchodilatation and asthma symptoms were well controlled with regular twice daily administration.
Adenovirus-associated, receptor-mediated delivery of hepatitis B virus DNA and oligonucleotides to liver cells
Authors: J MADON
Journal: Hepatology (1995)

Diagnosis of liver disease has improved because of progress in imaging technology. Among the imaging methods, magnetic resonance imaging (MRI) has the advantage of a lack of radiation exposure, but the basis of the method (imaging of hydrogen atoms in water molecules) makes it hard to detect changes in tissue or the location of the diseased tissue in the liver. The aims of this study are to develop new contrast media for visualization of functional changes in the liver and to check the effectiveness of the media.We developed a new molecular imaging contrast media that targets the asialoglycoprotein receptor (ASGP-R), a membrane protein that is specific to hepatocytes. We first checked the contrast media diameter and the cytotoxicity. Next, we examined the interaction of the media with ASGP-R through observation of fluorescein isothiocyanate (FITC)-labeled molecular imaging contrast media bound to normal hepatocellular ASGP-R using confocal laser scanning microscopy. Finally, we used MRI to observe hepatocyte interactions with the molecular imaging contrast media.The contrast media forms a nanoparticle of about 30 nm diameter in aqueous solution and the cytotoxicity is low. In vitro, the media has high specificity for ASGP-R in normal rat hepatocyte RLN-8 cells and this interaction was blocked by lactose (which has a similar molecular structure to that of galactose) and by an anti-ASGP-R antibody. The contrast media markedly enhanced T1-weighted images in MRI of normal rat hepatocytes compared to the signal strength for rat liver cancer cells.We have shown that our new contrast media for molecular imaging of hepatocytes by MRI is effective in vitro.
The Achilles Heel of the University Group Diabetes Program
Authors: Charles Kilo, J. Philip Miller, Joseph R. Williamson
Journal: JAMA (1980)

The controversial conclusions of University Group Diabetes Program (UGDP) investigators are refuted by new findings uncovered by analyses of patient data obtained from the UGDP Coordinating Center and by critical review of data previously published by UGDP investigators and the Biometric Committee. These new findings (1) document a notable discrepancy in the sex ratio of cardiovascular (CV) death rates in placebo-treated subjects, (2) show that all excess CV mortality in tolbutamide-treated subjects was restricted to a relatively small group of poorly controlled diabetics, and (3) provide evidence that insulin was efficacious in reducing CV deaths. The anomalous sex ratio of CV deaths in UGDP placebo-treated subjects dictates the conclusion that the CV death rate in placebo-treated subjects was spuriously low, giving the false impression of increased death rates in the other treatment groups, thereby accounting for all of the controversial observations reported by UGDP investigators. For this reason UGDP conclusions based on comparison with placebo-treated subjects should not be extrapolated to the general diabetic population.
Statistical analysis of COPD exacerbations
Authors: O. N. Keene, P. M. A. Calverley, P. W. Jones, J. Vestbo, J. A. Anderson
Journal: European Respiratory Journal (2008)

Bronchoconstriction, after removal of a catecholamine-producing tumour, is physiologically foreseeable owing to the sudden deprivation of catecholamines, as well as deprivation of other tumour-secreted bronchodilator substances, such as adrenomedullin [4], vasoactive intestinal peptide or pituitary adenylate cyclase-activating peptide [5].There are, however, few reports of respiratory problems in patients with pheochromocytoma and all, in contrast to ours, had a history of asthma and/or were being treated with b-blockers [6,7].Our patient has, since the acute post-operative period, been feeling perfectly well.She is back in the gym on a regular basis, her cardiac frequency is normal and she has not had any further respiratory problems.It is therefore good to keep in mind that bronchospasm, and not only cardiovascular collapse, is a possible incident that can occur after removal of a catecholamine-producing tumour.
Amiloride inhibits mammalian renal kallikrein and a kallikrein-like enzyme from toad bladder and skin.
Authors: H S Margolius, J Chao
Journal: Journal of Clinical Investigation (1980)

Renal kallikrein is localized in luminal plasma membranes of the mammalian distal nephron and gains access to urine from this site. Its activity is regulated, in part, by aldosterone. These facts led us to study the effects of amiloride, a drug known to inhibit sodium reabsorption and potassium secretion at this site, on kallikrein activity. Amiloride inhibited the esterolytic activity of purified rat or human urinary kallikrein or of rat renal cortical cells upon a synthetic substrate (ID50 = 0.12-0.23 mM). Kinetic analyses showed that the enzyme inhibition was noncompetitive and reversible in nature. The kinin-generating activity of kallikrein acting upon kininogen substrates was also inhibited by amiloride, as measured by bioassay in the rat uterus of guinea pig ileum or by radioimmunoassay of liberated kinins (ID50 = 85 microM). No other diuretic drug tested inhibited kallikrein activity, except triamterene, which did so, weakly. In addition, kallikrein-like enzyme activity was discovered in the urinary bladder or skin of Bufo marinus toads and this activity was also inhibited by amiloride. The localization of the enzyme and its inhibition by this drug suggest that further study of relationships amongst the glandular kallikrein-kinen system and renal ion and water transport is warranted.
Women in Medicine
Authors: Marietta M. henry
Journal: JAMA (1968)

Statistics concerning women in medicine—their numbers, motivations, problems, and attitudes—from the basis for this pleasant little book. There is no flag-waving for women's rights. This is an account of the sociological and emotional factors that determine which young girls aspire to enter medicine and complete medical training, and how they organize their lives. Why do some women become doctors? The effects of family goals are explored, as well as finances and, most of all, society's tendency to negate the idea of a profession for women. The problems encountered by women in the various phases of medical training, from undergraduate to residency level, are described and illustrated by personal interviews. There is a sensible discussion of the reactions and adaptations seen when women participate in the predominantly male profession. The combination of marriage and medicine is a challenge to the three fourths of all women doctors who are married. The competition
Diphtheria and Tetanus Immunity
Authors: Dominic J. Balestra
Journal: Annals of Internal Medicine (2002)

Letters5 November 2002Diphtheria and Tetanus ImmunityDominic J. Balestra, MDDominic J. Balestra, MDDartmouth College; Lebanon, NH 03766Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-9-200211050-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:What factors account for the more rapid age-specific decline in immunity to both diphtheria and tetanus, but especially diphtheria, discussed by McQuillan and colleagues (1)? The data suggest that few adult women are given decennial tetanus–diphtheria boosters and that adult men receive either tetanus–diphtheria or tetanus toxoid boosters throughout adulthood, presumably in emergency departments for wound prophylaxis. Alternatively, men receive many tetanus booster shots in young adulthood (for example, during military service), which confer more durable tetanus immunity into middle age than would childhood immunization alone. While the disparity between diphtheria immunity in adult men and women ...References1. McQuillan GM, Kruszon-Moran D, Deforest A, Chu SY, Wharton M. Serologic immunity to diphtheria and tetanus in the United States. Ann Intern Med. 2002;136:660-6. [PMID: 11992301] LinkGoogle Scholar2. Balestra DJ, Littenberg B. Should adult tetanus immunization be given as a single vaccination at age 65? A cost-effectiveness analysis. J Gen Intern Med. 1993;8:405-12. [PMID: 8410405] CrossrefMedlineGoogle Scholar3. Balestra DJ, Littenberg B. Tetanus immunization in adults [Letter]. JAMA. 1994;272:1900-1. [PMID: 7990239] CrossrefMedlineGoogle Scholar4. Balestra DJ. Tetanus immunization of the elderly [Letter]. J Gen Intern Med. 1991;6:487. [PMID: 1744772] CrossrefMedlineGoogle Scholar5. Mark DH. Visualizing cost-effectiveness analysis [Editorial]. JAMA. 2002;287:2428-9. [PMID: 11988064] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Dartmouth College; Lebanon, NH 03766 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSerologic Immunity to Diphtheria and Tetanus in the United States Geraldine M. McQuillan , Deanna Kruszon-Moran , Adamadia Deforest , Susan Y. Chu , and Melinda Wharton Metrics 5 November 2002Volume 137, Issue 9Page: 774-775KeywordsDiphtheriaHealth careImmunityMedical servicesProphylaxisSexual identityTetanusToxinsToxoidsVaccines ePublished: 5 November 2002 Issue Published: 5 November 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...