Three Nonnucleoside Reverse Transcriptase Inhibitor–Sparing Antiretroviral Regimens for Treatment-Naive Volunteers Infected With HIV-1
Authors: Giuseppe Lapadula, Andrea Gori
Journal: Annals of Internal Medicine (2015)

Letters17 March 2015Three Nonnucleoside Reverse Transcriptase Inhibitor–Sparing Antiretroviral Regimens for Treatment-Naive Volunteers Infected With HIV-1Giuseppe Lapadula, MD, PhD and Andrea Gori, MDGiuseppe Lapadula, MD, PhDFrom University Milano-Bicocca, Milan, Italy.Search for more papers by this author and Andrea Gori, MDFrom University Milano-Bicocca, Milan, Italy.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5066-2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their randomized, controlled trial, Lennox and colleagues (1) reported that discontinuations of atazanavir and ritonavir due to lack of tolerability were significantly more common than discontinuations of darunavir and ritonavir or raltegravir. This effect was mainly driven by atazanavir-induced jaundice and hyperbilirubinemia. This study is characterized by an innovative design in the field of HIV therapy because patients were allowed to change treatment groups if they were intolerant to randomly assigned treatment and because the time to discontinuation due to toxicity (as assessed and reported by the treating physician) was used as a predefined tolerability end ...References1. Lennox JL, Landovitz RJ, Ribaudo HJ, Ofotokun I, Na LH, Godfrey C, et al; ACTG A5257 Team. Efficacy and tolerability of 3 nonnucleoside reverse transcriptase inhibitor-sparing antiretroviral regimens for treatment-naive volunteers infected with HIV-1: a randomized, controlled equivalence trial. Ann Intern Med. 2014;161:461-71. [PMID: 25285539] doi:10.7326/M14-1084 LinkGoogle Scholar2. Cockburn J, Pit S. Prescribing behaviour in clinical practice: patients' expectations and doctors' perceptions of patients' expectations—a questionnaire study. BMJ. 1997;315:520-3. [PMID: 9329308] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Giuseppe Lapadula, MD, PhD; Andrea Gori, MDAffiliations: From University Milano-Bicocca, Milan, Italy.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0590. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEfficacy and Tolerability of 3 Nonnucleoside Reverse Transcriptase Inhibitor–Sparing Antiretroviral Regimens for Treatment-Naive Volunteers Infected With HIV-1 Jeffrey L. Lennox , Raphael J. Landovitz , Heather J. Ribaudo , Ighovwerha Ofotokun , Lumine H. Na , Catherine Godfrey , Daniel R. Kuritzkes , Manish Sagar , Todd T. Brown , Susan E. Cohn , Grace A. McComsey , Francesca Aweeka , Carl J. Fichtenbaum , Rachel M. Presti , Susan L. Koletar , David W. Haas , Kristine B. Patterson , Constance A. Benson , Bryan P. Baugh , Randi Y. Leavitt , James F. Rooney , Daniel Seekins , Judith S. Currier , and Efficacy and Tolerability of 3 Nonnucleoside Reverse Transcriptase Inhibitor–Sparing Antiretroviral Regimens for Treatment-Naive Volunteers Infected With HIV-1 Jeffrey L. Lennox , Raphael J. Landovitz , Heather J. Ribaudo , Ighovwerha Ofotokun , Lumine H. Na , Catherine Godfrey , Daniel R. Kuritzkes , Manish Sagar , Todd T. Brown , Susan E. Cohn , Grace A. McComsey , Francesca Aweeka , Carl J. Fichtenbaum , Rachel M. Presti , Susan L. Koletar , David W. Haas , Kristine B. Patterson , Constance A. Benson , Bryan P. Baugh , Randi Y. Leavitt , James F. Rooney , Daniel Seekins , Judith S. Currier , and Three Nonnucleoside Reverse Transcriptase Inhibitor–Sparing Antiretroviral Regimens for Treatment-Naive Volunteers Infected With HIV-1 Christoph Stephan Three Nonnucleoside Reverse Transcriptase Inhibitor–Sparing Antiretroviral Regimens for Treatment-Naive Volunteers Infected With HIV-1 Jeffrey L. Lennox , Raphael J. Landovitz , and Heather J. Ribaudo Three Nonnucleoside Reverse Transcriptase Inhibitor–Sparing Antiretroviral Regimens for Treatment-Naive Volunteers Infected With HIV-1 Christoph Stephan Three Nonnucleoside Reverse Transcriptase Inhibitor–Sparing Antiretroviral Regimens for Treatment-Naive Volunteers Infected With HIV-1 Jeffrey L. Lennox , Raphael J. Landovitz , and Heather J. Ribaudo Metrics 17 March 2015Volume 162, Issue 6Page: 461KeywordsAntiretroviralsClinical trialsDisclosureDrugsHIVHIV-1MotivationToxicity ePublished: 17 March 2015 Issue Published: 17 March 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...