tbuckley/cabot-search huggingface dataset:
Reviews and Notes: Slide Atlas of Clinical Endocrinology
Authors: Victor Adlin
Journal: Annals of Internal Medicine (1995)

Literature of Medicine15 November 1995Reviews and Notes: Slide Atlas of Clinical EndocrinologyVictor Adlin, MDVictor Adlin, MDTemple University School of Medicine Philadelphia, PA 19140Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-10-199511150-00039 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail 2nd edition. GM Besser and MO Thorner; eds. 1005 slides in 10 units. St. Louis: Mosby-Wolfe; 1994. $1050.00. ISBN 1563756420. Order phone 800-633-6699.Whether a picture is indeed worth a thousand words has been a subject of controversy in educational psychology. Current opinion seems to support the facilitation of prose learning by illustrations, provided that the illustrations are relevant to the text. Large individual differences in imaging ability and the cognitive processing of information are also important.For those who learn well from visual images and for teachers of endocrinology, Clinical Endocrinology and its supplementary slide atlas may prove useful. ... Author, Article, and Disclosure InformationAffiliations: Temple University School of Medicine Philadelphia, PA 19140 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1995Volume 123, Issue 10Page: 815-816KeywordsEndocrinologyGrowth hormoneHypothalamusPituitary glandPituitary tumorsPolycystic ovary syndromeProlactinPsychologySpineTriiodothyronine ePublished: 15 August 2000 Issue Published: 15 November 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Flavors of self-deception: Ontology and epidemiology
Authors: Harold A. Sackeim, Ruben C. Gur
Journal: Behavioral and Brain Sciences (1997)

Mele questions the prevalence and ontological status of strong forms of self-deception, as well as our attempt at experimental demonstration. Without validated indicators outside laboratory contexts, statements about prevalence are purely speculative. Conceptualizing self-deception without positing the motivated lack of awareness of a contradictory belief is unsatisfactory in dealing with issues of “agency,” that is, how can we stop the processing of threatening information unless we recognize that the information is threatening?
Psychosomatic Illness as a Result of a Deficit in Ego-Structure under Consideration of the Genetic, Dynamic, Structural, and Group Dynamic Point of View
Authors: Günter Ammon
Journal: Psychotherapy and Psychosomatics (1979)

Psychosomatic illness is an illness of ego-structure as a result of a narcissistic deficit reassembling the phenomenology of anaclitic depression in regard to the mother and the primary group. Psychosomatic illness has to be understood on a scale of ego-illnesses related to identity defects. The psychosomatic symptom restitutes the integration of the personality and constitutes the identity of a psychosomatic patient. The role of group dynamics is particularly stressed in relation to psychogenetics, psychodynamics, and the change of symptoms.
Peer reviewers can meet journals' criteria for authorship
Authors: T. C. Erren, M. Erren, D. M. Shaw
Journal: BMJ (2013)

The question of exactly who should receive credit and bear responsibility for scientific publications has been discussed repeatedly in recent years. The majority of journals in the medical arena adhere to the authorship standards that have been developed by the International Committee of Medical Journal Editors (ICMJE). The ICMJE’s Uniform Requirements for Manuscripts Submitted to Biomedical Journals aim to combat ghost and guest authorship and to allow appropriate recognition and accountability for what was done and how it is published. However, consideration of the ICMJE’s Ethical Considerations in the Conduct and Reporting of Research leads to the following questions. Should substantial contributions by peer reviewers be openly declared? Should some reviewers perhaps even be credited as authors?

Admittedly, reviewers’ contributions arrive after a study has been planned, conducted, analysed, and written up. However, diligent reviewers examine how research was designed and data collected, analysed, and interpreted (meeting ICJME criterion 1).1 In addition, reviewers suggest modifications to both design and text that often substantially improve the paper (criterion 2).1 The reviewer’s recommendation to accept the paper for publication could qualify as final approval of the paper (which is criterion 3).1 In …
Severe Neuralgia of the Uterus, following Premature Labour: Early Discharge of Liquor Amnii
Authors: W. Henry
Journal: BMJ (1862)

A LADY, aged 34, tall and well formed, the mother of three chlildren, was delivered at the seventh month of a female clhild, which died at the end of six days, after several convulsive paroxysms.The child weighed at birth only one pound and a quarter
Methods in Medical Ethics
Authors: Ernlé W. D. Young
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Role of Nitric Oxide in Coronary Vascular Effects of Estrogen in Postmenopausal Women
Authors: Victor Guetta, Arshed A. Quyyumi, Abhiram Prasad, Julio A. Panza, Myron Waclawiw, Richard O. Cannon
Journal: Circulation (1997)

Background At physiological concentrations, 17β-estradiol selectively enhances endothelium-dependent coronary vasodilation by an unknown mechanism in postmenopausal women. Methods and Results To assess the contribution of nitric oxide (NO) to the vascular effects of estradiol, we measured coronary epicardial and microvascular responses to intracoronary acetylcholine (range, 3 to 300 μg/min for 2 minutes) before and after intracoronary estradiol 75 ng/min for 15 minutes in 20 estrogen-deficient women, 16 of whom had angiographic evidence of atherosclerosis or risk factors for atherosclerosis. This testing was repeated after inhibition of NO synthesis with intracoronary N G -monomethyl- l -arginine (L-NMMA) 64 μmol/min for 5 minutes. Estradiol increased acetylcholine-stimulated coronary flow from 54±48% (mean±SD) above baseline values before estradiol infusion to 100±63% above baseline values ( P =.007) and decreased coronary resistance from 32±21% to 46±15% below baseline values ( P =.007) at a coronary sinus estradiol concentration of 1725±705 pmol/L (470±192 pg/mL). Estradiol also tended to lessen the severity of acetylcholine-induced epicardial coronary artery vasoconstriction from 8±11% to 3±11% below baseline values ( P =.123). However, during L-NMMA infusion, estradiol no longer potentiated the effects of acetylcholine on coronary flow dynamics; coronary flow increased 39±46% above baseline values and coronary resistance decreased 19±30% below baseline values (both P &lt;.001 versus pre–L-NMMA responses). The epicardial diameter decreased 8±11% below baseline values ( P =.06 versus pre–L-NMMA response). Conclusions The effects of estradiol at physiological concentrations on endothelium-dependent coronary vasodilator responsiveness in postmenopausal women are mediated by enhanced bioavailability of NO, which may be responsible in part for the cardioprotective effects of estrogen.
Safe storage of endoscopes: change in our guidelines?
Authors: M. Pietsch
Journal: Endoscopy (2007)

Endoscopes are complex instruments used in body areas that are extremely well colonized by microbes. For this reason, intensive contamination of endoscopes by microorganisms - both pathogenic and nonpathogenic - and other organic substances from the gastrointestinal tract is unavoidable [1]. Additionally, endoscopes are exposed during use to extreme mechanical stresses, first during the investigation procedure itself and then during the subsequent reprocessing. Unavoidable damage to the internal surfaces can promote the adherence of microorganisms and the substances mentioned above.
OBSERVATIONS CONCERNING THE PERSISTENCE OF LIVING CELLS IN MAITLAND'S MEDIUM FOR THE CULTIVATION OF VACCINE VIRUS
Authors: T. M. Rivers, E. Haagen, R. S. Muckenfuss
Journal: The Journal of Experimental Medicine (1929)

Cells survive for at least 5 days and at times are capable of multiplying in a mixture of serum and Tyrode's solution used by Maitland for the cultivation in vitro of vaccine virus.
Third trimester placental grading by ultrasonography as a test of fetal wellbeing
Authors: C. Fitzpatrick
Journal: BMJ (1987)

HIV testing: changing trends SIR,-Dr E J Beck and colleagues (18 July, p 191) drew attention to steep increases in the number of requests from patients in London for tests for antibody to the human immunodeficiency virus (HIV) in October and November 1986 and March 1987, which coincided with the publicity campaigns associated with the government's edu- cational programme about the acquired immune deficiency syndrome (AIDS).In Liverpool a similar trend was observed at the Public Health Laboratory, where these tests are performed on specimens submitted mainly from clinics for sexually transmitted diseases but also from hospital departments, drug dependency clinics, and general practitioners.The table shows the numbers of specimens for this test received monthly in the laboratory between May 1986 and June 1987, together with the number that were positive for antibody to HIV and the number of these that were from new patients.Sharp increases occurred in Liverpool at about the same time as in London, and, although, as in London, there was a pronounced fall in numbers from the peak in March 1987, the level maintained since then is much higher than that in the corresponding period in 1986.Though the proportion of patients who were found to be positive was much lower in Liverpool than in London, we also found that as the number of tests increased so the proportion that yielded positive results tended to decrease.Number of specimens for tests for antibody to HIV
Suicide and Pesticide Use among Pesticide Applicators and Their Spouses in the Agricultural Health Study
Authors: John D. Beard, David M. Umbach, Jane A. Hoppin, Marie Richards, Michael C. R. Alavanja, Aaron Blair, Dale P. Sandler, Freya Kamel
Journal: Environmental Health Perspectives (2011)

An association may exist between pesticide exposure and suicide.We sought to evaluate the existence of an association between pesticide use and suicide using data from the Agricultural Health Study (AHS), a prospective cohort study of licensed pesticide applicators and their spouses in Iowa and North Carolina.Via linkage to state mortality files and the National Death Index, we identified 110 suicides occurring between enrollment in the AHS (from 1993 to 1997) and 31 May 2009, among 81,998 cohort members contributing 1,092,943 person-years of follow-up. The average length of follow-up was 13.3 years. AHS participants provided data on pesticide use and potential confounders via self-administered questionnaires at enrollment. We evaluated several measures of pesticide use: use of any pesticide, ever use of 50 specific pesticides, cumulative lifetime days of use and intensity-adjusted cumulative lifetime days of use of 22 specific pesticides, and ever use of 10 functional and chemical classes of pesticides. We used Cox proportional hazards regression models to estimate adjusted hazard ratios and 95% confidence intervals.After adjusting for age at enrollment, sex, number of children in family, frequency of alcohol consumption during the past 12 months, and smoking status, we found no association between prior pesticide use and suicide in applicators and their spouses. Results were the same for applicators and spouses together or for applicators alone and were consistent across several measures of pesticide use.Our findings do not support an association between moderate pesticide use and suicide.
GROWTH OF CHILDREN THAT ARE BELOW AVERAGE WEIGHT
Authors: F. L. ROBERTS
Journal: JAMA (1927)

Do children that are below average weight tend to gain or lose ground when no active steps are taken with specific regard to nutrition? Do these children increase their weight with any regularity? Does the age or sex of these children bear any relation to the gain or loss of weight? This paper is the preliminary one of a series of studies that are being undertaken in an attempt to answer these questions.  MATERIAL AND METHODS  For the purposes of this study, 1,491 children, 901 girls and 590 boys, were followed through a period of from two to four years. These children were of American stock, living in rural and small town communities. They were weighed on accurate scales, and measured according to the method of Baldwin.1The measurements were taken at the same time each year, with the children in stocking feet and ordinary indoor clothing.  The standard
More on the Swan-Ganz Catheter
Authors: ANDREW GETTINGER
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 January 1986More on the Swan-Ganz CatheterANDREW GETTINGER, M.D., LINDA HERTZBERG, M.D.ANDREW GETTINGER, M.D.Search for more papers by this author, LINDA HERTZBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-1-122 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent perspective, Robin (1) criticizes the overuse and abuse of pulmonary arterial catheters. We share his concern about the indiscriminant use, the many risks, and the potential for inaccurate and therefore misleading data. However, we question his recommendation to curb drastically the use of these catheters until further trials are done.Robin finds little evidence in the literature supporting the benefits of pulmonary flow catheters. He cites an editorial by Lowenstein and Teplick (2) as notable for suggesting the need for prospective clinical trials, but ignores its message regarding ischemia detection and treatment with vasodilators....References1. ROBIN E. The cult of the Swan-Ganz catheter: overuse and abuse of pulmonary flow catheters. Ann Intern Med. 1985;103:445-9. LinkGoogle Scholar2. LOWENSTEINTEPLICK ER. To (PA) catheterize or not to (PA) catheterize—that is the question [Editorial]. Anesthesiology. 1980;53:361-3. CrossrefMedlineGoogle Scholar3. RAOJACOBSEL-ETR TKA. Reinfarction following anesthesia in patients with myocardial infarction. Anesthesiology. 1983;59:499-505. CrossrefMedlineGoogle Scholar4. BAELEMCMICHANMARSHSILLSOUTHORN PJHJP. Continuous monitoring of mixed venous oxygen saturation in critically ill patients. Anesth Analg (Cleve). 1982;61:513-7. MedlineGoogle Scholar5. ROBIN E. Overdiagnosis and overtreatment of pulmonary embolism: the emperor may have no clothes. Ann Intern Med. 1977;87:775-81. LinkGoogle Scholar1. ROBIN E. The cult of the Swan-Ganz catheter: overuse and abuse of pulmonary flow catheters. Ann Intern Med. 1985;103:445-9. LinkGoogle Scholar2. MCINTYRELEWIS KA, eds. Textbook of Advanced Cardiac Life Support. Dallas, Texas: American Heart Association; 1981. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Dartmouth-Hitchcock Medical Center Hanover, NH 03756 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Swan-Ganz Catheter: A decade of hemodynamic monitoring 1 January 1986Volume 104, Issue 1Page: 122-123KeywordsArterial lineCathetersClinical trialsIschemiaVasodilators Issue Published: 1 January 1986 PDF DownloadLoading ...
Eosinophilic Meningoencephalitis Caused by a Metastrongylid Lung-Worm of Rats
Authors: Leon Rosen
Journal: JAMA (1962)

As part of a study on eosinophilic meningitis in the Pacific area, postmortem material was examined from 2 mental patients who died in Hawaii with an eosinophilic meningoencephalitis. A number of young adult nematodes, identified as<i>Angiostrongylus cantonensis</i>, a rat lungworm, were found in the brain and meninges of 1 patient. Foreign material in the brain of the second patient and a cellular reaction similar to that observed in the first case suggested that this person also may have been infected with the same parasite. The presence of other abnormalities precluded an attempt to determine how many of either patient's symptoms might have been caused by this parasite. It was also not determined how either patient may have become infected.
Facial follicular porphyrin fluorescence: correlation with age and density of <i>Propionibacterium acnes</i>
Authors: KENNETH J. McGINLEY, GUY F. WEBSTER, JAMES J. LEYDEN
Journal: British Journal of Dermatology (1980)

The incidence and distribution of facial follicular porphyrin fluorescence was studied in a large group of subjects ranging in age from 1 to 90 years. Fluorescence appears first on the nose and chin, increases in incidence through adulthood and declines after the age of 50 possibly rflecting the ras population and confirmed that coproporphyrin III is proed in vivo.
Antibodies to Tumor Growth Factors Herald New Era in Chemotherapy
Authors: Beverly Merz
Journal: JAMA (1988)

TWO CLINICAL TRIALS based on blocking tumor-cell growth factors represent an approach that may transform the face of cancer chemotherapy within the next decade. The phase I studies now under way at the National Cancer Institute, Bethesda, Md, and Memorial Sloan-Kettering Cancer Center, New York City, involve antibodies to growth factors and their receptors. Because these agents intercede in a particular process in a particular type of tumor cell, they have potentially greater specificity and fewer side effects than the tumoricidal agents currently in use. Thus they may make it much easier to spare the patient<i>and</i>spoil the tumor. The first of these agents—a monoclonal antibody to gastrin-releasing peptide (GRP)—has been in phase I clinical trials for 18 months. The antibody, manufactured by Hybritech in San Diego, is raised to bombesin, a regulatory peptide isolated from frog skin. Bombesin is the amphibian analogue of GRP, which stimulates human bronchial
A NOTCH3-Mediated Squamous Cell Differentiation Program Limits Expansion of EMT-Competent Cells That Express the ZEB Transcription Factors
Authors: Shinya Ohashi, Mitsuteru Natsuizaka, Seiji Naganuma, Shingo Kagawa, Sotai Kimura, Hiroshi Itoh, Ross A. Kalman, Momo Nakagawa, Douglas S. Darling, Devraj Basu, Phyllis A. Gimotty, Andres J. Klein-Szanto, J. Alan Diehl, Meenhard Herlyn, Hiroshi Nakagawa
Journal: Cancer Research (2011)

Zinc finger E-box-binding (ZEB) proteins ZEB1 and ZEB2 are transcription factors essential in TGF-β-mediated senescence, epithelial-to-mesenchymal transition (EMT), and cancer stem cell functions. ZEBs are negatively regulated by members of the miR-200 microRNA family, but precisely how tumor cells expressing ZEBs emerge during invasive growth remains unknown. Here, we report that NOTCH3-mediated signaling prevents expansion of a unique subset of ZEB-expressing cells. ZEB expression was associated with the lack of cellular capability of undergoing NOTCH3-mediated squamous differentiation in human esophageal cells. Genetic inhibition of the Notch-mediated transcriptional activity by dominant-negative Mastermind-like 1 (DNMAML1) prevented squamous differentiation and induction of Notch target genes including NOTCH3. Moreover, DNMAML1-enriched EMT-competent cells exhibited robust upregulation of ZEBs, downregulation of the miR-200 family, and enhanced anchorage-independent growth and tumor formation in nude mice. RNA interference experiments suggested the involvement of ZEBs in anchorage-independent colony formation, invasion, and TGF-β-mediated EMT. Invasive growth and impaired squamous differentiation were recapitulated upon Notch inhibition by DNMAML1 in organotypic three-dimensional culture, a form of human tissue engineering. Together, our findings indicate that NOTCH3 is a key factor limiting the expansion of ZEB-expressing cells, providing novel mechanistic insights into the role of Notch signaling in the cell fate regulation and disease progression of esophageal squamous cancers.
British Columbia can sue tobacco industry for healthcare costs
Authors: Clare Dyer
Journal: BMJ (2004)

A Canadian court ruling last week has paved the way last week for the province of British Columbia to sue the tobacco industry for up to $C10bn (£4.1bn; $US7.3bn; €6.1bn) in smoking related healthcare costs.

The unanimous ruling from the British Columbia court of appeal follows a six year battle by the province to push through legislation allowing it to try to recover the costs …
Eligibility of non-residents for NHS treatment: Eligibility for HIV treatment needs special consideration
Authors: Nigel O'Farrell, Stephen Ash, Paul Fox, William Lynn
Journal: BMJ (2004)

EDITOR—We agree with Pollard and Savulescu that the new guidelines directed towards recovering costs for HIV from overseas visitors are not only unethical but also could lead to an escalation of new cases in the United Kingdom by failing to treat highly infectious cases with advanced immunosuppression.1

In this hospital most new HIV cases present with low CD4 cell …
Tissue-level transport mechanisms of intraperitoneally-administered monoclonal antibodies
Authors: Michael F. Flessner, Robert L. Dedrick
Journal: Journal of Controlled Release (1998)

Monoclonal antibodies (MAbs), produced for specific tumor antigens, can be linked with radioisotopes or metabolic toxins and administered intraperitoneally (i.p.) to treat metastatic cancer located on the peritoneum. Despite their specific binding properties, these proteins distribute to the serosal surface of all tissues surrounding the cavity in the same manner as other serum proteins. Recent data have raised a problem of access of the solution containing the MAb to significant portions of the peritoneal surface. If the MAb does arrive at the surface of the tumor, it penetrates via diffusion and convection. The rapidity and depth of penetration of the MAb are very dependent on the binding characteristics of the MAb to the tumor cells. Current data indicate that tumors often have a large interstitial space relative to normal muscle, and this can accelerate both diffusion and convection. However, a highly permeable tumor vasculature in the absence of lymphatic drainage has also been shown to produce interstitial pressure gradients from the center toward the periphery of the tumor, setting up a potential outward flow which may be a significant barrier to the movement of MAbs into the nodule. While theoretical mechanisms of diffusion, convection, and binding are well established, there is still a great need for in vivo data.