tbuckley/cabot-search huggingface dataset:
Behcet's syndrome and venous thrombosis.
Authors: D A Tibbut, D T Durack, J T MacFarlane, P J Teddy
Journal: BMJ (1973)

knowledge of the height and nude weight of the child and ready access to the nomogram itself.These surface area formulae are themselves subject to considerable error and discrepancy.To relate the dose of nalorphine to 1-73 m2 surface area entails further com- plicated mathematics, since not even the most precocious child is likely to have a surface area approaching that figure.Let us leave mathematics to the mathe- maticians and allow clinicians faced with res,piratory depression due to Lomotil to ventilate wit-h oxygen and to give the anti- dote based on the less complicated measurement of body weight.-Iam, etc.,
High density lipoprotein is not a major risk factor for ischaemic heart disease in British men
Authors: V Wynn, D Crook, I F Godsland, M Seed, N M Shennan
Journal: BMJ (1986)

MAy 1986 identical value.Hence, even if HDL cholesterol were of no relevance whatever to coronary heart disease-that is, if non-HDL cholesterol were the only thing that mattered-and if the two types of cholesterol were entirely uncorrelated with each other, then one would still find that, among people with the same total cholesterol, HDL cholesterol would tend to be inversely correlated with coronary heart disease, simply because low HDL cholesterol would then be an indicator of high non-HDL cholesterol.Thus, the chief question of interest is whether, given non-HDL
Etanercept for severe psoriasis and psoriatic arthritis: observations on combination therapy
Authors: S. Iyer, P. Yamauchi, N.J. Lowe
Journal: British Journal of Dermatology (2002)

The antitumour necrosis factor (TNF) activity of etanercept has been utilized to generate an important and novel treatment for rheumatoid arthritis. TNF has also been implicated in the pathogenesis of psoriasis.To determine whether blockade of TNF activity by etanercept may provide an additional treatment option for patients with psoriasis.In an uncontrolled trial, etanercept was added to the treatment regimen in six patients with severe recalcitrant psoriasis (three also with psoriatic arthritis) partially resistant to other ongoing systemic agents.In each case, the disease activity showed marked improvement on addition of etanercept therapy. No added toxicity was found with etanercept.Etanercept appears to be a promising immunomodulatory agent that can be used in combination therapy for the treatment of psoriasis, and a prospective controlled trial may be warranted.
MILKER'S NODULES
Authors: F. Ronchese
Journal: JAMA (1953)

<h3>To the Editor:</h3> —After noting Dr. Green's (<i>J. A. M. A.</i><b>152</b>:757 [June 20] 1953) and Dr. Lane's (<i>J. A. M. A.</i><b>152</b>:1067 [July 11] 1953) letters, and also for statistical purposes, I would like to add another published case of milker's nodules in New England (Ronchese, F.: Occupational Marks, New York, Grune &amp; Stratton, 1948, p. 162 [fig. 150]). These were seen on a farm worker in July, 1941. Site, clinical appearance, and histopathology contributed to the diagnosis. This is the only case I have seen in 25 years of practice in Rhode Island. The rarity undoubtedly is due to the milking machine having replaced manual labor on many farms. For this reason, milker's nodules are of little value as marks of the trade. A warty lesion on a farmer is not necessarily a milker's nodule. With uncertain bacteriological and histological features, I am inclined to rely
ON THE VALUE OF RAMISECTION IN CASES OF SPASTIC WEAKNESS.
Authors: C.P. Symonds, A.S.Blundell Bankart, W.R. Bristow, R.C. Elmslie, E.Laming Evans, H.A.T. Fairbank, G. Perkins, W.Gordon Pugh, W.H. Trethowan, P.J. Verrall
Journal: The Lancet (1930)
Demographic risk factors associated with elevated lead levels in Texas children covered by Medicaid.
Authors: D Kurtin, B L Therrell, P Patterson
Journal: Environmental Health Perspectives (1997)

This is the first large population-based study of demographic risk factors for elevated lead in Texas children. It summarizes data on 92,900 children covered by Medicaid screened for blood lead during the first 6 months of 1993 in Texas. The highest percentage of elevated lead levels (14.3%) was in children 25-36 months of age, with slightly lower percentages in those younger (13% of 19-24 months) and older (12% of 37-48 months) with blood lead levels greater than 10 micrograms/dl. The group with the highest percentage of elevated blood lead levels was 2-4-year-old African American males (17.3%) making this subgroup 3.5 times higher than the group with the lowest percentage-white girls over age 4 (4.8%). Males had higher blood lead levels for all ages and ethnic groups. Three principal risk factors were found for excessive blood lead in children: ethnicity, gender, and age; this is consistent with the second National Health and Nutrition Examination Survey (NHANES II) and Phase I of the NHANES III results demonstrating ethnicity and income association with lead in children in the United States.
In Vivo Temperature Heterogeneity of Atherosclerotic Plaques Is Determined by Plaque Composition
Authors: Stefan Verheye, Guido R.Y. De Meyer, Glenn Van Langenhove, Michiel W.M. Knaapen, Mark M. Kockx
Journal: Circulation (2002)

Temperature heterogeneity of atherosclerotic plaques has been associated with macrophage accumulation in ex vivo studies. We investigated in vivo whether modifying the cell composition of rabbit atherosclerotic plaques by dietary cholesterol lowering can influence temperature heterogeneity.Twenty New Zealand rabbits were randomized to either a normal (n=10) or cholesterol-rich (0.3%) diet (n=10) for 6 months. Thereafter, intravascular ultrasound and intravascular catheter-based thermography of the surface of aortic arch and descending aorta were performed in all animals. Ten control and 5 hypercholesterolemic rabbits were euthanized, and their aortas were analyzed histologically. The 5 remaining rabbits received a normal diet for 3 months and underwent repeat ultrasound and thermography before euthanasia followed by histology. Ex vivo temperature was measured in 3 additional rabbits at 6 months to correlate local temperature with local plaque composition. In control animals, plaque formation and temperature heterogeneity were absent. In hypercholesterolemic rabbits, plaque formation was prominent in the thoracic aorta. Plaques were composed of fibromuscular tissue and contained, underneath endothelial cells, an accumulation of foam cells of macrophage origin. Temperature heterogeneity was markedly elevated and increased with plaque thickness. Importantly, after 3 months of cholesterol lowering, plaque thickness remained unchanged, but temperature heterogeneity was significantly decreased. This paralleled plaque histology, which showed a marked loss of macrophages. The ex vivo experiments demonstrated the relation between local temperature and local total macrophage mass.In vivo temperature heterogeneity of rabbit atherosclerotic plaques is determined by plaque composition. In vivo thermography may have important clinical implications in the assessment of plaque composition.
Human papillomavirus 57 identified in a plantar epidermoid cyst
Authors: None Egawa, None Kitasato, None Honda, None Kawai, None Mizushima, None Ono
Journal: British Journal of Dermatology (1998)

We report a 23‐year‐old Japanese man who had plantar warts on the right sole, beneath one of which an epidermoid cyst developed. On microscopic examination, an acanthotic epidermis markedly invaginated into the underlying dermis, resulting in an open epidermoid cyst. Not only the polymerase chain reaction but also an in situhybridization detected HPV 57 DNA in the cyst. HPV 60 is the only type of HPV that has been identified in epidermoid cysts. To our knowledge, this is the first case report of an epidermoid cyst, in which a different type of virus from HPV 60 was identified. Histological features of the cyst were also different from those of HPV 60‐associated epidermoid cysts.
TRACING THE TRANSMISSION OF SYPHILIS
Authors: DUDLEY C. SMITH
Journal: JAMA (1933)

There is an attitude of aloofness shown by physicians in all branches of medicine toward the prevention of syphilis. This is due partly to the absence of proper example and leadership by the syphilologists, syphilis clinics and epidemiologists. Sexual transmission with its moral aspects has seemed to be an insurmountable hazard but is actually only a mental handicap. In fact, this type of close contact makes a source of infection easier to determine.  The average physician and specialist does not often look beyond the syphilitic patient. He shies away from seeming to seek patients and becoming embroiled in domestic affairs. Some of this attitude is due to false professional ethics and part is due to lack of energy and patience. The problem is such an enormous one when tackled in a wholesale way that most epidemiologists have not had the daring to assail it.  All of the facts necessary for
The silence of the limbs
Authors: E. M. Denovan-Wright, R. W. Currie
Journal: Cardiovascular Research (2011)

This editorial refers to ‘Silencing of Int6 gene restores function of the ischaemic hindlimb in a rat model of peripheral arterial disease’ by N. Okamoto et al ., pp. 209–217, this issue. 

Okamoto et al. 1 report that Int6 levels are reduced by direct administration of silencing small-interfering RNA (siRNA) into the hindlimb (adductor) muscles immediately following ligation of the external iliac artery. Ligation of the external iliac artery is a model of limb ischaemia. Ischaemia, whether in the brain, heart, or other tissue, is a complex metabolic injury. When a blood vessel is occluded, the underperfused area experiences a cascade of events beginning within 1 or 2 min and progresses for months. In tissue undergoing ischaemia, there is a gradient of injury that expands with time through space. The central area, where hypoxia is severe, becomes necrotic. With the initiation of ischaemia, as oxygen levels fall, ATP levels fall in the affected cells, and as minutes go by, ion pumps in the cell membranes stop. Various cell signalling pathways respond and transcription factors are activated and many changes occur in gene …
Abstract 489: Selective inhibitor of STAT1 sensitizes breast cancer cells to radiation therapy
Authors: Olga A. Timofeeva, Nadya Tarasova, Honghe Wang, Alan Perantoni, Anatoly Dritschilo
Journal: Cancer Research (2010)

Abstract About 70% of breast cancer patients with progressive disease are resistant to conventional cancer treatments such as adjuvant chemotherapy and/or radiation therapy. Recently, the STAT1 signaling pathway has been identified as a predictive marker of poor outcome in breast cancer patients and as a factor responsible for radiation and chemotherapy resistance. STAT1 was initially considered as a tumor suppressor, since it causes growth arrest and apoptosis after stimulation with interferons and in response to DNA damage. However, constitutive activation/overexpression of STAT1 results in pro-survival cellular signaling via enhancement of expression of pro-survival proteins Mcl-1 and Hsp27 that might be responsible for observed radiation resistance of breast cancer cells. It may therefore be beneficial to sensitize patients with resistant disease to radiation or chemotherapy by inhibiting STAT1 signaling, yet there has been little effort to develop direct inhibitors of STAT1. We have recently developed a selective inhibitor ST1-Hel2A-2 that directly binds to the N-terminal domain of STAT1, but not other STAT family members, and inhibits STAT1 transcriptional activity (ACS Chem Biol, 2007. 2(12): 799). The inhibitor kills breast cancer cells at nanomolar concentrations but does not effect survival of normal mammary epithelial cells. We have now found that inhibition of STAT1 N-domain can further sensitize breast cancer cells to ionizing radiation. The mechanism for observed sensitization at least partially depends on down-regulation of STAT1 target genes, including pro-survival Hsp27. In addition, ST1-Hel2A-2 is capable of disrupting the STAT1 N-domain protein-protein interactions. Yeast two-hybrid screening has revealed that the STAT1 N-domain associates with double-stranded RNA-activated protein kinase (PKR) and DNA glycosylase NEIL1. Both PKR and NEIL1 facilitate DNA repair after ionizing radiation and protect mammalian cells from radiation-mediated cell death. ST1-Hel2A-2 disrupts STAT1 interactions with both proteins resulting in a reduced DNA repair capacity. Our data suggest that a novel inhibitor of STAT1 decreases radiation resistance of breast cancer cells through downregulation of pro-survival genes and inhibition of DNA repair. Inhibition of STAT1 signaling appears to be a promising strategy in overcoming radiation resistance and can be used as an effective treatment of metastatic breast cancer when combined with conventional therapies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 489.
Passage of Diphenylhydantoin Across The Placenta
Authors: E. J. Randinitis
Journal: JAMA (1970)

<h3>To the Editor:—</h3> The levels of diphenylhydantoin in the plasma of a young epileptic mother, in cord blood, and in the serum of her healthy newborn son were essentially equal, indicating that diphenylhydantoin freely crosses the placental barrier. The infant's serum levels suggest a first-order disappearance of diphenylhydantoin and a biological half-life of approximately 19 hours. It is known that diphenylhydantoin crosses the placenta but to our knowledge, there have been no definitive studies reporting diphenylhydantoin levels in newborn infants.<sup>1</sup>The current study demonstrates that diphenylhydantoin freely crosses the placenta reaching equilibrium in the maternal and fetal blood. <h3>Methods and Materials.—</h3> A 19-year-old gravida 1, para 0, white woman gave birth to a healthy, 3,075 gm (6 lb 12 1/2 oz) male child at 8:15 p.m., May 12,1969. Diphenylhydantoin, 100 mg four times a day, had been prescribed for her upon the diagnosis of a seizure disorder in November
Antibody Deficiency Syndrome Associated with Dysgammaglobulinemia.
Authors: Werner F. Barth
Journal: Annals of Internal Medicine (1964)

s1 April 1964Antibody Deficiency Syndrome Associated with Dysgammaglobulinemia.Werner F. Barth, M.D., Thomas J. Liddy, M.D., Yasukazu Tanaka, M.D., Richard A. Malmgran, M.D., John L. FaheyWerner F. Barth, M.D.Search for more papers by this author, Thomas J. Liddy, M.D.Search for more papers by this author, Yasukazu Tanaka, M.D.Search for more papers by this author, Richard A. Malmgran, M.D.Search for more papers by this author, John L. FaheySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-739_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe association of the antibody deficiency syndrome with agammaglobulinemia is well known. Similar immune deficiency syndromes characterized by repeated infections and a poor response to antigenic challenge also may occur in patients with selective deficiencies of the immunoglobulins, that is, dysgammaglobulinemia. Investigation of these cases has helped to shed light on human genetics, immunoglobulin production, and antibody formation.Observations in a 15-year-old Navajo Indian female with marked reduction of the β2Aand 6.6S gamma globulins associated with elevated γ1-macroglobulin levels will be reported. This child has had repeated infections since 2 years of age characterized by recurrent pneumonia, sinusitis, and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Werner F. Barth, M.D.; Thomas J. Liddy, M.D.; Yasukazu Tanaka, M.D.; Richard A. Malmgran, M.D.; John L. FaheyAffiliations: Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1964Volume 60, Issue 4Page: 739-739KeywordsAntibody responseAntigensGlobulinsHuman geneticsImmune deficiencyImmune responsePediatric infectionsPneumonia ePublished: 1 December 2008 Issue Published: 1 April 1964 PDF downloadLoading ...
Predictors of Attendance for Prostate-Specific Antigen Screening Tests and Prostate Biopsy
Authors: Kerry N.L. Avery, Chris Metcalfe, Kavita Vedhara, J. Athene Lane, Michael Davis, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, Jane M. Blazeby
Journal: European Urology (2012)
Dominant-Stable β-Catenin Expression Causes Cell Fate Alterations and Wnt Signaling Antagonist Expression in a Murine Granulosa Cell Tumor Model
Authors: Derek Boerboom, Lisa D. White, Sophie Dalle, José Courty, JoAnne S. Richards
Journal: Cancer Research (2006)

Abstract Wnt/β-catenin signaling is normally involved in embryonic development and tissue homeostasis, and its misregulation leads to several forms of cancer. We have reported that misregulated Wnt/β-catenin signaling occurs in ovarian granulosa cell tumors (GCT) and have created the Catnbflox(ex3)/+;Amhr2cre/+ mouse model, which expresses a dominant-stable mutant of β-catenin in granulosa cells and develops late-onset GCT. To study the mechanisms leading to GCT development, gene expression analysis was done using microarrays comparing Catnbflox(ex3)/+;Amhr2cre/+ ovaries bearing pretumoral lesions with control ovaries. Overexpressed genes identified in Catnbflox(ex3)/+;Amhr2cre/+ ovaries included the Wnt/β-catenin signaling antagonists Wif1, Nkd1, Dkk4, and Axin2, consistent with the induction of negative feedback loops that counteract uncontrolled Wnt/β-catenin signaling. Expression of the antagonists was localized to cells forming the pretumoral lesions but not to normal granulosa cells. Microarray analyses also revealed the ectopic expression of bone markers, including Ibsp, Cdkn1c, Bmp4, and Tnfrsf11b, as well as neuronal/neurosecretory cell markers, such as Cck, Amph, Pitx1, and Sp5. Increased expression of the gene encoding the cytokine pleiotrophin was also found in Catnbflox(ex3)/+;Amhr2cre/+ ovaries and GCT but was not associated with increased serum pleiotrophin levels. In situ hybridization analyses using GCT from Catnbflox(ex3)/+;Amhr2cre/+ mice revealed that Wnt/β-catenin antagonists and neuronal markers localized to a particular cell population, whereas the bone markers localized to a distinct cell type associated with areas of osseous metaplasia. Together, these results suggest that misregulated Wnt/β-catenin signaling alters the fate of granulosa cells and that the GCT that arise in Catnbflox(ex3)/+;Amhr2cre/+ mice result from the clonal expansion of metaplastic cells. (Cancer Res 2006; 66(4): 1964-73)
Lipoprotein(a) for Risk Assessment in Patients With Established Coronary Artery Disease
Authors: Michelle L. O'Donoghue, David A. Morrow, Sotirios Tsimikas, Sarah Sloan, Angela F. Ren, Elaine B. Hoffman, Nihar R. Desai, Scott D. Solomon, Michael Domanski, Kiyohito Arai, Stephanie E. Chiuve, Christopher P. Cannon, Frank M. Sacks, Marc S. Sabatine
Journal: Journal of the American College of Cardiology (2013)
S100A12 provokes mast cell activation: A potential amplification pathway in asthma and innate immunity
Authors: Zheng Yang, Wei Xing Yan, Hong Cai, Nicodemus Tedla, Chris Armishaw, Nick Di Girolamo, Hong Wei Wang, Taline Hampartzoumian, Jodie L. Simpson, Peter G. Gibson, John Hunt, Prue Hart, J. Margaret Hughes, Michael A. Perry, Paul F. Alewood, Carolyn L. Geczy
Journal: Journal of Allergy and Clinical Immunology (2006)
Successful treatment of steatocystoma multiplex by simple surgery
Authors: M. KEEFE, BARBARA J. LEPPARD, G. ROYLE
Journal: British Journal of Dermatology (1992)

Journal Article Successful treatment of steatocystoma multiplex by simple surgery Get access M. KEEFE, M. KEEFE Royal South Hants Hospital, Graham Road, Southampton SO9 4PE, U.K. Search for other works by this author on: Oxford Academic Google Scholar BARBARA J. LEPPARD, BARBARA J. LEPPARD Royal South Hants Hospital, Graham Road, Southampton SO9 4PE, U.K. Dr B.J.Leppard Search for other works by this author on: Oxford Academic Google Scholar G. ROYLE G. ROYLE Royal South Hants Hospital, Graham Road, Southampton SO9 4PE, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 127, Issue 1, 1 July 1992, Pages 41–44, https://doi.org/10.1111/j.1365-2133.1992.tb14825.x Published: 01 July 1992
Long-term beneficial effects in sustained responders to interferon-alfa therapy for chronic hepatitis C
Authors: Savino Bruno, Pier Maria Battezzati, Giorgio Bellati, Aldo Manzin, Marco Maggioni, Andrea Crosignani, Mauro Borzio, Laura Solforosi, Alberto Morabito, Gaetano Ideo, Mauro Podda
Journal: Journal of Hepatology (2001)
Vertebral Augmentation for Symptomatic Compression Fractures Is Supported by Randomized Clinical Trials
Authors: Jason R. Levy, Douglas P. Beall
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
A Large Multilocular Ovarian Tumour
Authors: F. A. Baldwin
Journal: BMJ (1900)

A UARGE MULTILOCULAR OVARIANThe cedema of the legs (Fig. 2) was due, to the pressure of LARGE ~~~~~~~~~~the abdomen on the saphena and femoral veins.It was quite TUMOUR.impossible to lift the overhanging abdomen, but subsequently BY F. A. BA-LDWIN, M.R