tbuckley/cabot-search huggingface dataset:
Chronic Pain and Tricyclic Antidepressants
Authors: Eugene H. Rubin, Charles F. Zorumski
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 March 1981Chronic Pain and Tricyclic AntidepressantsEUGENE H. RUBIN, M.D., PH.D., CHARLES F. ZORUMSKI, M.D.EUGENE H. RUBIN, M.D., PH.D., CHARLES F. ZORUMSKI, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-3-415_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the recent article (1) on the management of patients with chronic pain syndromes. The authors review the use of psychoactive medications in certain patients with pain syndromes and conclude that "the combination of a tricyclic antidepressant with a substituted phenothiazine or a butyrophenone . . . seems to be more efficacious than either drug alone." Due to the potential risks from long-term neuroleptic use, we feel that it is essential to evaluate the benefits versus the risks associated with the use of such agents.There are numerous reports that tricyclic antidepressants may be...References1. REULERGIRARDNARDONE JDD. The chronic pain syndrome: misconceptions and management. Ann Intern Med. 1980;93:588-96. LinkGoogle Scholar2. COUCHHASSANEIN JR. Amitriptyline in migraine prophylaxis. Arch Neurol. 1979;36:695-9. CrossrefMedlineGoogle Scholar3. HART F Chairman. A symposium on psychotropic drugs and pain. J Int Med Res. 1976:4(Suppl 2):1-80. Google Scholar4. TAUB A. Relief of post-herpetic neuralgia with psychotropic drugs. J Neurosurg. 1973;39:235-9. CrossrefMedlineGoogle Scholar5. MCGEEALEXANDER JM. Phoenothiazine analgesia—fact or fantasy? Am J Hosp Pharm. 1979;36:633-40. MedlineGoogle Scholar6. . Tardive dyskinesia: summary of a task force report of the APA. Am J Psychiatry. 1980;137:1163-72. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington University in St. Louis School of Medicine St. Louis MO 63110 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Efficacy of Amitriptyline and Acetaminophen in the Management of Acute Low Back PainChronic pain 1 March 1981Volume 94, Issue 3Page: 415-415KeywordsAntipsychoticsDrugsPhenothiazineTricyclic antidepressants Issue Published: 1 March 1981 PDF downloadLoading ...
Inadvertent Intravenous Administration of Racemic Epinephrine
Authors: Stephen C. Kurachek
Journal: JAMA (1985)

NEBULIZED racemic epinephrine is used to relieve respiratory distress in patients with upper airway edema caused by prior endotracheal intubation or laryngotracheobronchitis (croup). Although side effects are uncommon when the drug is used as recommended, a recent report discussed complications that arose when racemic epinephrine was accidentally administered orally to small infants.<sup>1</sup>Our report describes the consequences of an inadvertent intravenous administration of this medication and the potential hazard of withdrawing nonparenteral medications from their containers by syringe. <h3>Report of a Case</h3> A 13-month-old, 8.6-kg infant was hospitalized with clinical and radiographic evidence of croup. Progressive respiratory distress prompted transfer to the intensive care unit the following day. When the infant developed cyanosis and bradycardia during a coughing episode, preparations for endotracheal intubation were begun. Nebulized racemic epinephrine (0.25 mL of 2.25% racemic epinephrine in 2.0 mL of normal saline) had been administered with oxygen eight times during the
Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy
Authors: Emilie Collmann, Thomas Bohnacker, Romina Marone, Janet Dawson, Markus Rehberg, Rowan Stringer, Fritz Krombach, Christoph Burkhart, Emilio Hirsch, Gregory J. Hollingworth, Matthew Thomas, Matthias P. Wymann
Journal: Journal of Allergy and Clinical Immunology (2013)
The Hemostatic Defect Produced by Carbenicillin
Authors: Clarence H. Brown, Ethan A. Natelson, W. Bradshaw, Temple W. Williams, Clarence P. Alfrey
Journal: New England Journal of Medicine (1974)

Blood coagulation and platelet function were examined in 17 human volunteers receiving doses of 300, 400 or 600 mg per kilogram per day of carbenicillin. Platelet function was also investigated in five patients receiving carbenicillin for the treatment of gram-negative infection. In volunteers, plasma coagulation remained normal. However, defective platelet function was seen in all volunteers and patients. Eleven of 11 volunteers demonstrated abnormal adenosine-diphosphate-induced platelet aggregation; six of 11 demonstrated abnormal l-epinephrine-induced aggregation, and five of 11 abnormal collagen-induced aggregation; in 14 of 20 studies, there was prolongation of bleeding time; seven of 11 volunteers had reduced clot retraction; eight of 11 had decreased prothrombin consumption. Prolongation of bleeding time and defective clot retraction appeared to be dose dependent. Three volunteers given 600 mg per kilogram per day and two patients given 340 and 375 mg per kilogram per day, respectively, experienced bleeding while receiving carbenicillin. The mechanism of platelet inhibition by carbenicillin is unknown. (N Engl J Med 291:265–270, 1974)
Prognostic Value of Thymidylate Synthase, Ki-67, and <i>p53</i> in Patients With Dukes’ B and C Colon Cancer: A National Cancer Institute–National Surgical Adjuvant Breast and Bowel Project Collaborative Study
Authors: Carmen J. Allegra, Soon Paik, Linda H. Colangelo, Allyson L. Parr, Ilan Kirsch, George Kim, Pamela Klein, Patrick G. Johnston, Norman Wolmark, H. Samuel Wieand
Journal: Journal of Clinical Oncology (2003)

Purpose: To define the value of thymidylate synthase (TS), Ki-67, and p53 as prognostic markers in patients with stage II and III colon carcinoma. Patients and Methods: We retrospectively analyzed the prognostic value of TS, Ki-67, and p53 in 706 patients with Dukes’ B (291 patients) or Dukes’ C (415 patients) colon carcinoma who were treated with either surgery alone (275 patients) or surgery plus fluorouracil (FU)-leucovorin chemotherapy (431 patients) in National Surgical Adjuvant Breast and Bowel Project (NSABP) protocols C01-C04. All three markers were assayed using immunohistochemical techniques. Results: Using 5 years of follow-up data, our retrospective analysis demonstrated an association between TS intensity (relapse-free survival [RFS]: risk ratio [RR] = 1.46, P = .01; overall survival [OS]: RR = 1.54, P = .002), Ki-67 (RFS: RR = 0.76, P = .05; OS: RR = 0.62, P = .001), and p53 (RFS: RR = 1.49, P = .01; OS: RR = 1.21, P = .18) for RFS and OS. High TS intensity levels and positive p53 staining were associated with a worse outcome. Tumors containing a high percentage of Ki-67-positive cells enjoyed an improved outcome compared with those patients whose tumors contained relatively few positive cells. An interaction with treatment was not identified for any of the markers. Conclusion: This retrospective investigation demonstrated that TS, Ki-67, and p53 staining each had significant prognostic value for patients with Dukes’ B and C colon carcinoma. However, none of the markers could be used to clearly discern groups of individuals who would be predicted to derive greater or lesser benefit from the use of adjuvant chemotherapy.
Bartenders' Respiratory Health After Establishment of Smoke-Free Bars and Taverns
Authors: Mark D. Eisner
Journal: JAMA (1998)

Context.—The association between environmental tobacco smoke (ETS) exposure and respiratory symptoms has not been well established in adults.Objective.—To study the respiratory health of bartenders before and after legislative prohibition of smoking in all bars and taverns by the state of California.Design.—Cohort of bartenders interviewed before and after smoking prohibition.Setting and Participants.—Bartenders at a random sample of bars and taverns in San Francisco.Main Outcome Measures.—Interviews assessed respiratory symptoms, sensory irritation symptoms, ETS exposure, personal smoking, and recent upper respiratory tract infections. Spirometric assessment included forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) measurements.Results.—Fifty-three of 67 eligible bartenders were interviewed. At baseline, all 53 bartenders reported workplace ETS exposure. After the smoking ban, self-reported ETS exposure at work declined from a median of 28 to 2 hours per week (P<.001). Thirty-nine bartenders (74%) initially reported respiratory symptoms. Of those symptomatic at baseline, 23 (59%) no longer had symptoms at follow-up (P<.001). Forty-one bartenders (77%) initially reported sensory irritation symptoms. At follow-up, 32 (78%) of these subjects had resolution of symptoms (P<.001). After prohibition of workplace smoking, we observed improvement in mean FVC (0.189 L; 95% confidence interval [CI], 0.082-0.296 L; 4.2% change) and, to a lesser extent, mean FEV1 (0.039 L; 95% CI, −0.030 to 0.107 L; 1.2% change). Complete cessation of workplace ETS exposure (compared with continued exposure) was associated with improved mean FVC (0.287 L; 95% CI, 0.088-0.486; 6.8% change) and mean FEV1 (0.142 L; 95% CI, 0.020-0.264 L; 4.5% change), after controlling for personal smoking and recent upper respiratory tract infections.Conclusion.—Establishment of smoke-free bars and taverns was associated with a rapid improvement of respiratory health.
Clinical Benefits of Remote Versus Transtelephonic Monitoring of Implanted Pacemakers
Authors: George H. Crossley, Jane Chen, Wassim Choucair, Todd J. Cohen, Douglas C. Gohn, W. Ben Johnson, Eleanor E. Kennedy, Luc R. Mongeon, Gerald A. Serwer, Hongyan Qiao, Bruce L. Wilkoff
Journal: Journal of the American College of Cardiology (2009)
Multidisciplinary Treatment for Advanced Invasive Thymoma with Cisplatin, Doxorubicin, and Methylprednisolone
Authors: Kohei Yokoi, Haruhisa Matsuguma, Rie Nakahara, Tetsuro Kondo, Yukari Kamiyama, Kiyoshi Mori, Naoto Miyazawa
Journal: Journal of Thoracic Oncology (2007)
Don't Be Rigid About Flexible Sigmoidoscopy
Authors: Lesli Taylor
Journal: JAMA (1987)

<h3>To the Editor.—</h3> Numerous studies<sup>1-7</sup>have compared rigid sigmoidoscopy with flexible lower gastrointestinal endoscopy, and in most the flexible endoscopic procedure has been shown to be superior because of the greater length of bowel examined, the greater yield of pathological lesions, decreased patient discomfort, and wider physician and patient acceptance. All reports emphasize the number of lesions missed by the rigid sigmoidoscope because of its limited length and all presume that the alternative—flexible endoscopy—is as efficacious as rigid sigmoidoscopy in detecting distal lesions. We are aware of only one report<sup>8</sup>comparing the two modalities in which a lesion that was seen with the rigid sigmoidoscope was not seen during examination by flexible sigmoidoscopy. We recently encountered two patients with synchronous colonic cancers in which one of the lesions was not detected during examination by flexible sigmoidoscopy, which was performed by an experienced endoscopist. In the first case, the
New technique for investigating bacterial flora of female periurethral area.
Authors: W Brumfitt, J M Hamilton-Miller, M Bakhtiar, J Cooper
Journal: BMJ (1976)

The bacterial flora of the female periurethral area was studied by impression cultures taken by polystyrene sponges, the results being recorded by photographic contact printing. With this technique it is possible to observe the preferential colonisation of different areas by different organisms and to detect persistent colonisation by pathogens. In assessing the possible aetiological importance of these results, and especially in comparing them with the findings of other workers, it is essential to use correct anatomical nomenclature.
The Nephropathy of Potassium Depletion
Authors: Arnold S. Relman, William B. Schwartz
Journal: New England Journal of Medicine (1956)

IT is the purpose of this report to describe the clinical and functional aspects of the renal disease associated with potassium depletion in man, and to correlate these with the histologic changes found in renal tissue obtained by serial biopsies.It is well known that experimental depletion of potassium produces renal tubular lesions in rats.1 2 3 Although there have been a few recent reports of renal lesions in human subjects dying with potassium deficiency,4 5 6 7 the clinical and physiologic implications of the renal damage have not received attention until recently. A previous report8 described 2 patients in whom marked but apparently reversible . . .
KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation
Authors: Youl-Nam Lee, Stephanie Brandal, Pierre Noel, Erik Wentzel, Joshua T. Mendell, Michael A. McDevitt, Reuben Kapur, Melody Carter, Dean D. Metcalfe, Clifford M. Takemoto
Journal: Blood (2011)
TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway
Authors: Masahiro Yamamoto, Shintaro Sato, Hiroaki Hemmi, Satoshi Uematsu, Katsuaki Hoshino, Tsuneyasu Kaisho, Osamu Takeuchi, Kiyoshi Takeda, Shizuo Akira
Journal: Nature Immunology (2003)
The Harveian Oration Delivered before the Royal College of Physicians
Authors: W. A. Guy
Journal: BMJ (1875)

Corner, was the scene of a most touching ceremony.In library of the noble building" which he had cost, furnished, supplied with books, objects of curiosity, surgical instruments, and three years previously presented College, 'William Harvey met th! Fellows, his colleagues, friends, pupils, for the last time.Bent beneath the weight of nearly years, worn by repeated attacks of a painful malady, " only stricken in years", but afflicted with more and more health", conscious that his life must be drawing to a close (he a year afterwards), Harvey formally resignled the upwards of forty years; and, as the crowning act many deed of princely munificence, made over to the College his paternal Harvey's object in so doing was to incite other Fellows and members College deeds of liberality,to search and study out the nature by way of experiment", and to cultivate mutual love among themselves: his means to these ends, an oration to annually within the College.Such, brief, is the origin of this day's ceremony; a ceremony which, upwards two centuries, has been the occasion of gathering together, year by year, the elite of the medical profession, with many a worthy representative of every department of learning and literature, The appointment of the Harveian orator rests, as is well known, President of our College.Were it not so-if I were a voluniteer, chosen for the duty I have this day to perform-I should begin my by words of self depreciation; but these, under the circum- stances, would be obviously out of place.Assuming, then, a certain undefined and wholly undefinable degree of competence, I address myself earnestly to the task of justifying the President's choice, fulfilling your reasonable expectations, and approaching, as near as my powers permit, to my own ideal of what is due to the dignity of this College memory of its brightest ornament and greatest benefactor.lapse of time and altered circumstances have, as you are aware, brought about deviations from the original design of the Harveian oration.lieu of the Latin tongue, once the written and spoken language of the learned, we now use our own native English, which pro- mises some day to be to the whole world what Latin was to the educated section of a small part of it; and, by a sort of general understanding consent, we meet on this occasion to do honour to Harvey himself, man who, above and beyond all others,
Reduced-intensity versus conventional myeloablative conditioning allogeneic stem cell transplantation for patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation
Authors: Mohamad Mohty, Myriam Labopin, Liisa Volin, Alois Gratwohl, Gérard Socié, Jordi Esteve, Reza Tabrizi, Arnon Nagler, Vanderson Rocha
Journal: Blood (2010)
Practical Observations on Delirium
Authors: T. Salter
Journal: BMJ (1850)

terminates before birth their structure is entirely re- moved, when their function is continued up to birth some traces, at any rate, of their structure are persistent through life.The Wolffian bodies and the omphalo-mesenteric duct, for instance, have entirely disappeared at birth; except in a few cases where the remains of the latter are preserved, in the form of a 'diverticulum, connected with the lower end of the ilium, the omphalo-mesenteric vessels being also, in such cases, sometimes represeslted by a thick cord passing from the diverticulum to the mesentery.It is a fact of some practical importance that when a foetal structure is persistent it is endued with the same growing properties as the rest of the body.This is true of those foetal structures which are always persistent; for instance, the remains of the umbilical arteries and veins not only increase in length, but acquire also considerable thickness, and form strong tough cords of fibrous tissue.It is true also of those structures which are occasionally persistent: thus a diverticulum often equals the intestine in size, and the remains of the omphalo-mesenteric vessels when they are persistent form a thick, strong, fibrous cord, which has been known to strangulate large portions of bowel en- tangled in the loop between it andthe mesentery.There is a specimen of this sort in the museum of the College 'of Surgeons, and there is another, probably of the same kind, in the pathological museum belonging to the University of Cambridge.The membrane uniting the labia, which in the little child is so thin and soft that it easily yields to the pressure of a probe, is in the adult so thick and strong as to withstand the expulsive force of the uterus, and to require a scalpel for its division.In this respect, as well as in some other particulars, 'observation.
Needle-Knife Papillotomy: A Helpful and Safe Adjunct to Endoscopic Retrograde Cholangiopancreatography in a Selected Population
Authors: C. Rollhauser, M. Johnson, F. H. Al-Kawas
Journal: Endoscopy (1998)

Background and Study Aims: Needle-knife papillotomy (NKP) has been shown to be a useful alternative when standard techniques fail to provide access during ERCP. A retrospective review was conducted to reevaluate the indications, efficacy, and complications of NKP at a tertiary referral center.
Cornified envelopes in congenital disorders of keratinization
Authors: S. MICHEL, L. JUHLIN
Journal: British Journal of Dermatology (1990)

A morphological and biochemical analysis was made of cornified envelopes isolated from patients with different congenital disorders. Nomarski contrast microscopy of the envelopes showed that their morphology was not greatly altered in several types of keratoderma and parapsoriasis, but it was grossly modified in ichthyotic disorders. The various types of ichthyoses, keratoderma palmoplantare, KID syndrome and parapsoriasis showed, after cyanogen-bromide cleavage, peptide patterns similar to those obtained from healthy subjects. In contrast, envelopes from patients with Darier's disease, congenital pachyonychia and erythrokeratoderma variabilis showed markedly different peptide patterns.
Hypoglycemm Increases the Gastric Emptying Rate in Healthy Subjects
Authors: Erik Schvarcz, Mats Palmér, Jan Åman, Christian Berne
Journal: Diabetes Care (1995)

OBJECTIVES To compare the gastric emptying rate during normoglycemia with that during insulin-induced hypoglycemia in healthy subjects. RESEARCH DESIGN AND METHODS In eight healthy subjects, the rate of gastric emptying of an isotope-labeled meal was assessed by a scintigraphic technique during normoglycemia and hypoglycemia, both controlled by an insulin-glucose clamp. RESULTS The mean time taken to empty 50% of the test meal from the stomach (Tg0) for the solid phase was 43.0 ± 20.0 min during normoglycemia, compared with 16.3 ± 6.6 min during hypoglycemia, P &amp;lt; 0.001. The mean T50 for the liquid phase was 38.0 ± 21.2 and 15.4 ± 10.6 min, respectively, P &amp;lt; 0.001. CONCLUSIONS Insulin-induced hypoglycemia increases the gastric emptying rate in healthy subjects.
Basic Science Content in the USMLE Step 1
Authors: John S. Barbieri
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HBsAg andHBx knocked into thep21 locus causes hepatocellular carcinoma in mice
Authors: Youliang Wang, Fang Cui, Yaxin Lv, Cuiling Li, Xiaoling Xu, Chuxia Deng, Dongping Wang, Yansong Sun, Gengxi Hu, Zhenwei Lang, Cuifen Huang, Xiao Yang
Journal: Hepatology (2004)

Hepatocellular carcinoma (HCC) affects males in a significantly higher proportion than females and is one of the human cancers etiologically related to viral factors. Many studies provide strong evidence of the direct role that hepatitis B virus (HBV) plays in hepatic carcinogenesis, but the functions of HBV surface antigen (HBsAg) and X protein (HBx) in hepatocarcinogenesis through direct or indirect mechanisms are still being debated. We generated two HBV gene knock-in transgenic mouse lines by homologous recombination. HBsAg and HBx genes were integrated into the mouse p21 locus. Both male and female p21-HBx transgenic mice developed HCC after the age of 18 months; however, male p21-HBsAg transgenic mice began to develop HCC 3 months earlier. The expression of a number of genes related to metabolism and genomic instability largely resembled the molecular changes during the development of HCC in humans. ER-beta (estrogen receptor-beta) was extremely up-regulated only in tumor tissues of male p21-HBsAg mice, providing genetic evidence that HBsAg might be the major risk factor affecting the gender difference in the causes of HCC. In conclusion, these mice might serve as good models for studying the different roles of HBsAg and HBx in early events of HBV-related hepatocarcinogenesis.
Government underestimated complexity of moving people with learning difficulties out of hospital, report says
Authors: G. Iacobucci
Journal: BMJ (2015)

The government failed to meet its target to move people with learning disabilities and challenging behaviour out of hospital by 1 June 2014 because it underestimated the complexity of the task, the national public spending watchdog has said.

A report by the National Audit Office1 said that the government had not determined the scale of the challenge involved in increasing the number of community placements to the levels set out …