tbuckley/cabot-search huggingface dataset:
Long-Term Outcomes of Significant Mitral Regurgitation After Percutaneous Mitral Valvuloplasty
Authors: Mi-Jeong Kim, Jae-Kwan Song, Jong-Min Song, Duk-Hyun Kang, Young-Hak Kim, Cheol Whan Lee, Myeong-Ki Hong, Jae-Joong Kim, Seong-Wook Park, Seung-Jung Park
Journal: Circulation (2006)

Mild commissural mitral regurgitation (MR) is associated with significantly higher restenosis-free survival after percutaneous mitral valvuloplasty (PMV), which suggests that different mechanisms of significant MR after PMV may have different clinical courses. We therefore analyzed long-term prognostic factors of significant MR after PMV.Echocardiographic and clinical follow-up data on 380 patients were analyzed (286 women, mean age 44+/-11 years) who underwent PMV with the Inoue balloon technique between 1995 and 2000. Significant MR developed in 47 patients (12.4%). The survival rate at 8 years was 96+/-3% and 98+/-10% in patients with and without significant MR, respectively (P=0.084). The most frequent mechanism was commissural MR, or MR that originated at the site of successful commissurotomy, which occurred in 27 of 47 patients (57%), whereas noncommissural MR occurred in 20 (43%) patients, 12 (26%) with subvalvular damage resulting in chordae rupture and flail motion and 8 (17%) with leaflet laceration. The 8-year event-free survival rate was significantly lower in patients with significant MR than in those without (47+/-8% versus 83+/-3%, P<0.001) and was significantly higher in patients with commissural versus noncommissural MR (63+/-11% versus 29+/-11%, P<0.001). Of the 47 patients with significant MR, who were followed up for 74+/-29 months, 19 patients (40%) underwent mitral valve replacement, and 28 patients (60%) received medical treatment only. Patients with commissural MR had a significantly lower rate of mitral valve replacement than patients with noncommissural MR (15% versus 70%, P<0.001). Multivariate analysis showed that atrial fibrillation (odds ratio, 7.4; 95% CI, 1.1 to 56.4; P=0.038), mean mitral gradient immediately after PMV (odds ratio, 1.5; 95% CI, 1.1 to 2.0; P=0.009), and the mechanism of MR (odds ratio, 16.7; 95% CI, 2.3 to 122.2; P=0.005) were independent factors associated with mitral valve replacement.Clinical outcome of patients with significant MR after PMV varied according to MR mechanism and the adequacy of hemodynamic improvement, which is easily assessed by echocardiography immediately after PMV.
Vitamin K and childhood cancer.
Authors: R. W. Miller
Journal: BMJ (1992)

incidents jointly with the British Association for Accident and Emergency Medicine.The association organises courses on major incidents, and the five day course on immediate care includes formal training on the same subject.The diploma in immediate medical care of the Royal College of Surgeons of Edinburgh examines candidates on skills gained in these courses.The courses and the diploma are much more relevant to on site medical services at major incidents than the much promoted advanced trauma life support courses, which relate to the care of a single patient by a single doctor in hospital.4We believe that the key issues are, firstly, that the person serving as medical incident officer must be properly trained in managing major incidents and must participate regularly in exercises with colleagues from other services; and, secondly, that members of site medical teams must regularly work outside hospital on the many cases of trauma seen in day to day practice.
A study of the photodegradation of leukotriene B4 by ultraviolet irradiation (UVB, UVA)
Authors: B. MILLAR, C. GREEN, J. FERGUSON, E.J. RAFFLE, T.M. MACLEOD
Journal: British Journal of Dermatology (2006)

In view of the presence of the polymorphonuclear leukocyte (PMN) chemoattractant Leukotriene B4 (LTB4) in the surface scale of the psoriatic lesion and the known therapeutic effect of phototherapy in psoriasis, the photostability of LTB4 was investigated. LTB4 was irradiated with dosages of UVB (290–320 nm) ranging from 100–1500 mJ cm−2 and with dosages of UVA (320–400 nm) ranging from 5–40 J cm−2. Topical application of UVB irradiated LTB4 to the forearm skin of normal volunteers showed a marked reduction in cutaneous erythema, paralleled histologically by reduced transepidermal PMN migration when compared with sites of application of unirradiated and UVA irradiated LTB4. High performance liquid chromatography (HPLC) demonstrated a dose-dependent photodegradation of LTB4 by UVB irradiation. UVA irradiation produced no such effect. The wavelengths responsible lie within the absorption spectrum of LTB4. In vitro chemotaxis studies, using an under agarose technique, showed a statistically significant reduction in the migration of PMN from both psoriatic and non-psoriatic subjects to the UVB irradiated LTB4 compared with the unirradiated LTB4, whilst UVA irradiated LTB4 produced a normal PMN chemotactic response.
Association Between Major Perioperative Hemorrhage and Stroke or Q-Wave Myocardial Infarction
Authors: Hooman Kamel, S. Claiborne Johnston, John C. Kirkham, Christopher G. Turner, Jorge R. Kizer, Richard B. Devereux, Costantino Iadecola
Journal: Circulation (2012)

Background— Hemorrhage is associated with ischemic complications in cardiac patients. The nature of this relationship in surgical patients is unknown. Methods and Results— We examined the association between major perioperative hemorrhage and stroke or myocardial infarction among adults who underwent surgery from 2005 through 2009 at centers participating in the National Surgical Quality Improvement Program. We excluded patients with emergent, trauma-related, transplantation, cardiac, or neurological operations. Major hemorrhage was defined as bleeding necessitating transfusion of &gt;4 U of packed red blood cells or whole blood. Stroke was defined as focal brain dysfunction lasting ≥24 hours from a vascular cause. A diagnosis of myocardial infarction required new ECG Q waves. Outcomes were assessed from surgery until 30 days afterward. Among 651 775 patients who underwent surgery, 5233 (0.80%) experienced major hemorrhage, 1575 (0.24%) developed Q-wave myocardial infarction, and 1321 (0.20%) suffered a stroke. In Cox proportional hazards analyses controlling for vascular risk factors, illness severity, and type of surgery, hemorrhage was independently associated with subsequent stroke (hazard ratio, 2.5; 95% confidence interval, 1.9–3.3) and subsequent Q-wave myocardial infarction (hazard ratio, 2.7; 95% confidence interval, 2.1–3.4). Interaction terms revealed no significant variation in these associations by age, sex, or type of surgery. Our results were robust across multiple sensitivity analyses. Conclusions— Major perioperative hemorrhage is associated with subsequent stroke and myocardial infarction in patients undergoing noncardiac, nonneurological surgery. This suggests the need for randomized trials to guide perioperative use of antiplatelet drugs, which affect the risk of both bleeding and vascular events.
860 SYNERGISTIC ANTITUMORAL EFFECT OF SUBCUTANEOUS INOCULATION WITH AFP-PULSED DC COMBINED WITH INTRATUMORAL INJECTION OF CD40L-EXPRESSING DC IN ESTABLISHED HEPATOCELLULAR TUMORS (HCC) IN VIVO
Authors: T. Ayub, A. Vogt, W.H. Caselmann, T. Sauerbruch, M.A. González-Carmona
Journal: Journal of Hepatology (2010)
Tests of tubal patency: comparison of laparoscopy and hysterosalpingography.
Authors: O A Lapido
Journal: BMJ (1976)

Tubal patency in 86 infertile patients was investigated by hysterosalpingography and the laparoscopic methylene blue test. Hysterosalpingography indicated 33 cases of interstitial tubal occlusion, 18 cases of fimbrial occlusion, and 8 cases of combined occlusions. Laparoscopy indicated 28 cases of interstitial tubal occlusion, 18 cases of fimbrial occlusion, and 7 combined cases. In addition, laparoscopy revealed 57 cases of periadnexal adhesions and 13 cases of fimbrial phimosis in patients with tubal patency, while hysterosalpingography revealed only 4 cases of periadnexal adhesions. There was good correlation between the 2 procedures in 70% of the cases. Nonetheless, the laparoscopic detection of periadnexal adhesions and fimbrail phimosis demonstrates the advantage of laparoscopy in the diagnosis of subfertility.
Charity challenges government's plans to scrap legal aid for negligence claims
Authors: C. Dyer
Journal: BMJ (2011)

The patient safety charity AvMA (Action against Medical Accidents) has launched a legal challenge to UK government plans to axe legal aid for clinical negligence claims in England and Wales.

AvMA is seeking the high court’s permission to apply for judicial review of the plans, which form part of the Legal Aid, Sentencing and Punishment of Offenders Bill now going through parliament.

The government argues that the sort of cases now brought with the help of legal aid can in future be conducted on a no win, no fee …
Spontaneous regression in non‐hodgkin's lymphoma: Clinical and pathogenetic considerations
Authors: William R. Drobyski, Raman Qazi
Journal: American Journal of Hematology (1989)

Abstract The spontaneous regression (SR) of tumor has been noted in a variety of neoplastic conditions. In non‐Hodgkin's lymphoma, this phenomenon has been reported in indolent histologic subtypes, with a frequency of 10–20% in selected series. Invstigators evaluating new therapies for lymphomas with a favorable histology need to be cognizant of SR's impact. Mechanisms which have been proposed to explain SR have included the role of contemporaneous bacterial or viral infection, as well as an augmented host immune response which is able to mediate tumor regression via humoral and cellular effector mechanisms. The ability to recapture immunoregulatory control is aptly illustrated by lymphomas developing after organ transplantation where reduction of immunosuppression has, on occasion, resulted in tumor regression. The importance of immune regulation of B‐cell lymphoma is also suggested by the tumor's responses to immunotherapy and interferons in vivo and by the biologic and pathologic characteristic of indolent lymphomas being analogous, in may respects, to benign neoplasms. Indolent lymphomas which differ from aggressive lymphomas in their clinical and biological behavior may be more responsive to these host immunoregulatory influences. Review of clinical experience as well as proposed mechanisms of spontaneous regression in non‐Hodgkin's lymphoma will be explored in this report.
Outcome of acute mesenteric ischemia in the intensive care unit: a retrospective, multicenter study of 780 cases
Authors: Marc Leone, Carole Bechis, Karine Baumstarck, Alexandre Ouattara, Olivier Collange, Pascal Augustin, Djillali Annane, Charlotte Arbelot, Karim Asehnoune, Olivier Baldési, Simon Bourcier, Laurence Delapierre, Didier Demory, Baptiste Hengy, Carole Ichai, Eric Kipnis, Etienne Brasdefer, Sigismond Lasocki, Matthieu Legrand, Olivier Mimoz, Thomas Rimmelé, Jugurtha Aliane, Pierre-Marie Bertrand, Nicolas Bruder, Fanny Klasen, Emilie Friou, Bruno Lévy, Oriane Martinez, Eric Peytel, Alexandra Piton, Elisa Richter, Kamel Toufik, Marie-Charlotte Vogler, Florent Wallet, Mourad Boufi, Bernard Allaouchiche, Jean-Michel Constantin, Claude Martin, Samir Jaber, Jean-Yves Lefrant
Journal: Intensive Care Medicine (2015)
Children Are Not Expendable
Authors: John J. Connel
Journal: New England Journal of Medicine (1953)

IN A city such as Boston, which abounds in good homes and therefore good people and good children, it is disturbing to me, as judge of the Juvenile Court, to find a recent serious increase in delinquency. In fact, as of this date in the Boston Juvenile Court, we are over 100 cases beyond last year's total figure, with yet over three months to go. More disturbing is the fact that the crimes committed are serious offenses. Does this suggest that there has been a lowering of the standards of education, discipline and morality in youth?It is not reassuring . . .
What Is the Role of Genome Duplication in the Evolution of Complexity and Diversity?
Authors: K. D. Crow
Journal: Molecular Biology and Evolution (2005)

Gene and genome duplications provide a source of genetic material for mutation, drift, and selection to act upon, making new evolutionary opportunities possible. As a result, many have argued that genome duplication is a dominant factor in the evolution of complexity and diversity. However, a clear correlation between a genome duplication event and increased complexity and diversity is not apparent, and there are inconsistencies in the patterns of diversity invoked to support this claim. Interestingly, several estimates of genome duplication events in vertebrates are preceded by multiple extinct lineages, resulting in preduplication gaps in extant taxa. Here we argue that gen(om)e duplication could contribute to reduced risk of extinction via functional redundancy, mutational robustness, increased rates of evolution, and adaptation. The timeline for these processes to unfold would not predict immediate increases in species diversity after the duplication event. Rather, reduced probabilities of extinction would predict a latent period between a genome duplication and its effect on species diversity or complexity. In this paper, we will develop the idea that genome duplication could contribute to species diversity through reduced probability of extinction.
Status of Human Plasma as a Plasma Volume Expander
Authors: Harold F. Hamit
Journal: JAMA (1960)

<h3>Review of Plasma Studies</h3> Although transfusions of plasma were suggested, they were not tried as substitutes for blood transfusions during World War I. Numerous studies of plasma were made during the period between World War I and World War II, but most of them are not particularly relevant to this report. Wartime enthusiasm for the use of plasma began in 1939 when Tatum and associates<sup>1</sup>recommended it as "an ideal substitute for whole blood in emergency treatment of shock and hemorrhage from war wounds." During subsequent months, others echoed these recommendations. In 1945, DeBakey and Carter<sup>2</sup>commented that the misconception concerning plasma as a "blood substitute" became so widespread and so firmly entrenched in the minds of both administrative and professional personnel that it impeded the organization and the development of more effective measures for the management of shock. The first lesson to be learned, then, was that,
Changing the hideous face of war.
Authors: B J Grogono
Journal: BMJ (1991)

simply be replaced by a better one?Why live a parsimonious and careful life if the miracle of medical technology provides an alternative?Technology steps in after the damage has been done, at a far greater cost to society but at much more dramatic level.As long as these values are held in our society, as long as popular culture continues both to reflect and to reproduce these values, public health practitioners will be seen as spoilsports, not saints. 1
ABC of resuscitation. Resuscitation of infants and children.
Authors: D Zideman
Journal: BMJ (1986)

In 1984 in England and Wales there were 6037 infant deaths (9 5 per 1000 live births): 281 occurred in the first week oflife and 3544 in the first month.(Although these statistics include infants dying at birth, delivery room resuscitation has a different aetiology and in the vast majority ofcases should be a planned event.It is considered separately in next week's article.)At the same time accidents were the second most common cause of death leninfant death syndrome in children aged 1-4 (92 per million population) and the most common ofblood and bodily fluids cause ofdeath in children aged 5-14 (86 per million population).Ifmost of these children are considered to befit and healthy before their accident it is surprising that paediatric resuscitation does not play a more prominent part icaemia in both community and hospital resuscitation programmes.Hypoxia is the most common cause ofcardiac arrest in infants and children.Sudden infant death syndrome; the loss of blood or bodyfluids, as in gastroenteritis and resulting in circulatory hypovolaemia; congenital heart disease; and septicaemia are also notable causes.Treatment must be immediate to be effective; delays in recognising or treating a cardiac arrest or therapeutic mistakes may seriously affect the outcome. Basic life support. ; a .a ; * .i .
A REPORT OF A CASE OF ANOMALOUS THORACIC ANEURYSM.
Authors: G. W. JOHNSON
Journal: JAMA (1898)

Aneurysm of the aorta is not an uncommon occurrence in the experience of every physician, and from the group of symptoms found in text-books on practice and surgery is not especially difficult of diagnosis. That there are exceptional cases, however, in which a diagnosis is somewhat difficult, there is little doubt. Such a case is the one herein reported. After having studied this case for some months and then being unable to make a satisfactory diagnosis, I presented the case to the Chicago Medical Society for diagnosis. A number of its most able clinicians became interested, and after considerable study and repeated examinations agreed upon a diagnosis of lymphosarcoma of the mediastinum, the tumor occupying the right thorax. The clinical and personal history, together with postmortem notes and the author's deductions, are here given in full: <h3>Personal history.</h3> —W. D., aged 53 years, Irish, unmarried, is a plumber by occupation,
Parathyroid Hormone in the Evaluation of Hypercalcemia
Authors: Natalie E. Cusano, John P. Bilezikian
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Treatment of Uterine and Peri-Uterine Affections by the Method of Dr. Apostoli
Authors: G. Elder
Journal: BMJ (1887)

ISIS,Z#j*iQYX4o I[t1wI tumours-of the.phari have bee-n observed by Porter and Syme, due to,eum of the intern'al carotid; and BarnesP has deqcribed a phAryngeaspulsating tumour which was arrested by applying psrwsure, to the external carotid artery.Cresswell Baber3 ha recently reported a cosetppulsating artery on the posterior wall of the pliaryax.It is probable that this condition is by no means rare, since it has been oboorved at the Throat Hospital at least twice during the last year.
Allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia with t(6;9)(p23;q34) dramatically improves the patient prognosis: a matched-pair analysis
Authors: K Ishiyama, A Takami, Y Kanda, S Nakao, M Hidaka, T Maeda, T Naoe, S Taniguchi, K Kawa, T Nagamura, Y Atsuta, H Sakamaki
Journal: Leukemia (2011)
Thyroid Cancer After Radioactive Iodine Therapy
Authors: James T. McClintock
Journal: JAMA (1974)

<h3>To the Editor.—</h3> In reference to the letter, "Thyroid Cancer After Iodine-131 Therapy" (227:438, 1974), by I. Ross McDougall, MB, ChB, I think several things should be mentioned for completeness: Although a long-term follow-up series reports no incidence of thyroid cancer, it cannot be cited as proof that cancer does not occur.<sup>1</sup> Not only low-dose radioactive iodine therapy but all other forms of treatment seem to result in eventual hypothyroidism. Radiation-induced cancers of the thyroid gland are the well-differentiated types. Thyrotoxicosis has a real probability of fatal outcome. (It may be small, but it's real.) Well-differentiated thyroid cancer has an excellent prognosis. Morbidity associated with thyroidectomy is significant, and there is a real probability of surgical death. There is essentially no morbidity and no probability of fatal outcome with radioactive iodine treatment. Antithyroid drugs seem to be inducing a much smaller proportion of remission. I take the position that
STUDIES ON TUBERCLE BACILLUS-MONOCYTE RELATIONSHIP
Authors: Jacob Fong, Patricia Schneider, Sanford S. Elberg
Journal: The Journal of Experimental Medicine (1957)

Studies of virulent, attenuated, and avirulent strains of tubercle bacilli have demonstrated the proficiency of virulent strains to effect degeneration of normal monocytes cultivated in the presence of normal serum. Attenuated strains were less active in this respect, and avirulent bacilli failed to induce monocytic degeneration. Comparison of the effects of virulent H37Rv with O.T., P.P.D., and a culture filtrate of H37Rv revealed a similarity in action of H37Rv and its filtrate. The action of O.T. and P.P.D. differed from that of H37Rv in that the greatest effect of H37Rv was upon normal cells as opposed to the effect of O.T. and P.P.D. upon immune cells. Additionally, it was demonstrated that immune serum (anti-BCG) protected immune cells against H37Rv but not against O.T. or P.P.D. The protection of immune cells by heterologous antisera (anti-Salmonella and anti-ovalbumin) as well as by homologous antiserum (anti-BCG) against the degenerative effects of H37Rv indicated a non-specificity in action of serum factors. The ability of the monocytes of animals immunized with BCG and the failure of monocytes of animals immunized with Salmonella rutgers to withstand parasitization with H37Rv, when both types of monocytes were cultivated in immune (anti-BCG) serum, indicated a specificity of cellular resistance.
The spectrum of allergic (cross-)sensitivity in clinical patch testing with 'para amino' compounds
Authors: W. Uter, H. Lessmann, J. Geier, D. Becker, T. Fuchs, G. Richter
Journal: Allergy (2002)

Allergic contact sensitization to 'para amino' compounds is frequent and the spectrum of cross-reactivity between members of this chemical group is variable.A retrospective analysis of clinical patch test data obtained with a special test series in the centres of the Information Network of Departments of Dermatology (IVDK) between 1995 and 1999.In the 638 patients tested with the above test panel positive reactions were observed most often to p-aminoazobenzene (16.2%), p-phenylenediamine (14.1%), p-toluylenediamine (10.0%), followed by 4,4'-diaminodiphenylmethane (8.5%), Disperse Orange 3 (8.4%) and p-aminophenol (3.1%). Among the 544 patients tested with p-phenylenediamine and all seven additional 'para amino' compounds, concordance between reactions varied greatly. The stronger the positive test reaction to p-phenylenediamine, p-toluylenediamine or p-aminoazobenzene, the more frequently additional positive reactions to the other compounds were observed.A screening employing several 'para amino' compounds is necessary to describe the individual spectrum of allergic contact sensitization, as there is no reliable marker substance. Further research should aim at (i) establishing the mechanism of cross-reactivity to 'para amino' compounds and (ii) identifying exposures in the environment.
The Position of a Human Body Burnt, but not Completely Destroyed, by Fire
Authors: J. Becker
Journal: BMJ (1894)

BURINT BODY. Jot RNL sitiOn oii the undevelope(d condition of the genital orgaiis, the bladder being small, thle urethlra narrow, and the gullCous membrane sensitive and liable, to laceration.Onl the ,other hand, lithotoiny in the child lhad always been a coini- paratively successful operation; and, so far as in A' ownv