tbuckley/cabot-search huggingface dataset:
Role of breast tumour kinase in the in vitro differentiation of HaCaT cells
Authors: T.C. Wang, S.H. Jee, T.F. Tsai, Y.L. Huang, W.L. Tsai, R.H. Chen
Journal: British Journal of Dermatology (2005)

Journal Article Role of breast tumour kinase in the in vitro differentiation of HaCaT cells Get access T.C. Wang, T.C. Wang Department of Dermatology, College of Medicine, National Taiwan University and National Taiwan University Hospital, Taipei, TaiwanDepartment of Dermatology, West Garden Hospital and Mackay Memorial Hospital, Taipei, Taiwan Search for other works by this author on: Oxford Academic Google Scholar S.H. Jee, S.H. Jee Department of Dermatology, College of Medicine, National Taiwan University and National Taiwan University Hospital, Taipei, Taiwan Search for other works by this author on: Oxford Academic Google Scholar T.F. Tsai, T.F. Tsai Department of Dermatology, College of Medicine, National Taiwan University and National Taiwan University Hospital, Taipei, Taiwan Search for other works by this author on: Oxford Academic Google Scholar Y.L. Huang, Y.L. Huang Department of Dermatology, College of Medicine, National Taiwan University and National Taiwan University Hospital, Taipei, Taiwan Search for other works by this author on: Oxford Academic Google Scholar W.L. Tsai, W.L. Tsai Department of Dermatology, College of Medicine, National Taiwan University and National Taiwan University Hospital, Taipei, Taiwan Search for other works by this author on: Oxford Academic Google Scholar R.H. Chen R.H. Chen Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan Ruey‐Hwa Chen. E‐mail: rhchen@ha.mc.ntu.edu.tw Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 2, 1 August 2005, Pages 282–289, https://doi.org/10.1111/j.1365-2133.2005.06604.x Published: 01 August 2005 Article history Accepted: 01 January 2005 Published: 01 August 2005
Neurobehavioral Effects of Anticonvulsants
Authors: David W. Loring
Journal: JAMA (1991)

<h3>To the Editor.</h3> —We cannot agree with the<i>JAMA</i>editorial by Trimble<sup>1</sup>that phenytoin produces greater impairment of cognitive functions than either carbamazepine or valproate sodium. The studies cited by Trimble have both methodological and statistical shortcomings that limit the confidence with which conclusions can be drawn, and his literature review selectively omits contradictory results. Thompson et al<sup>2,3</sup>examined the effects of phenytoin and valproate on healthy subjects in separate studies and concluded that phenytoin produces greater functional impairment. However, results from these reports cannot be compared directly since they were not derived using identical approaches to data analysis (ie, treatment minus baseline difference scores for phenytoin<sup>2</sup>and drug vs placebo contrasts for valproate<sup>3</sup>). To directly compare results from these studies, we calculated the Student<i>t</i>tests from their data. Comparing phenytoin with valproate treatment, we observed significant differences for both color (<i>P</i>&lt;.01) and category
Diabetes and Cancer
Authors: Elliott P. Joslin, Herbert L. Lombard, Ruth E. Burrows, Miriam D. Manning
Journal: New England Journal of Medicine (1959)

STUDIES of the association of diabetes and cancer have been conducted over a period of years, but evidence of a positive relation remains inconclusive. One of the earliest reports was submitted by Maynard1 in 1910. One of the most recent was a monograph by Jacobson2 in 1948. During the intervening years, a number of reports were prepared, only a few of which are mentioned here.3 4 5 Doering,6 using data from the Registration Area of 1920, demonstrated a positive correlation between the two diseases. Stevenson,7 on the other hand, in 1921, showed no relation between diabetes and cancer, the correlation coefficient being . . .
Data on effect of HRT on breast cancer conflict with other data
Authors: R Vidya
Journal: BMJ (2000)

EDITOR—Stallard et al suggest that breast tumours that develop in users of hormone replacement therapy have no favourable prognostic features.1 Their data conflict with those reported by other groups 2 3 and with data from our unit.

View this table:

Comparison of tumour characteristics in users and non-users of hormone replacement therapy. Values are …
Staphylococcus aureus Cowan I. Potent stimulus of immunoglobulin M rheumatoid factor production.
Authors: A I Levinson, L Tar, C Carafa, M Haidar
Journal: Journal of Clinical Investigation (1986)

These studies demonstrate that Staphylococcus aureus Cowan I (SAC), a protein A-positive Staphylococcal strain, is a potent and consistent inducer of IgM rheumatoid factor production by normal human peripheral blood mononuclear cells. The frequency and magnitude of this response greatly exceeded that of parallel cultures stimulated with pokeweed mitogen or the protein A-negative S. aureus Wood strain, although all three agents induced a similar amount of total IgM. Cell fractionation studies indicated that SAC-induced IgM rheumatoid factor is T cell-dependent. The striking ability of SAC to induce IgM rheumatoid factor may relate to its protein A content, since cultures stimulated with protein A-coupled sepharose beads also consistently produced this autoantibody. Thus SAC is a new probe of in vitro IgM rheumatoid factor production and its use has provided further evidence that most healthy individuals harbor precursors of IgM rheumatoid factor secreting cells. Unlike other polyclonal activators, SAC is unique in its capacity to bind immunoglobulin, a property that may account for its prominent anti-IgG inducing capacity.
SEVERE NOSEBLEED AND ITS TREATMENT
Authors: Olav E. Hallberg
Journal: JAMA (1952)

As many small boys know from experience, and others will learn soon, bleeding from the nose, as a rule, ceases spontaneously. Epistaxis then can be classed as a relative emergency by the physician. I do not think any of us need rush to see patients who have epistaxis because if enough time elapses the bleeding of about 80% of them will be checked without treatment. However, it is well to remember that when bleeding is persistent, a serious degree of anemia and occasionally death may result.  Deficiencies in the clotting mechanism of the blood are seldom contributing factors in nasal hemorrhage. The bleeding is oftener due to a leak in the side of a vessel, which simply bursts open. When an older person has such a leaking vessel, the vessel tends to gape because of the sclerotic changes in arteries and veins and atrophy of smooth muscle. The bleeding of
Benign intracranial hypertension and Cushing's disease.
Authors: P K Newman, M Snow, P Hudgson
Journal: BMJ (1980)

Benign intracranial hypertension and Cushing's diseaseBenign intracranial hypertension is found typically in obese young women, often associated with parity, the contraceptive pill, and other changes in hormonal state.'More rarely the syndrome is seen as a complication of Addison's disease, during withdrawal of cortico- Comment A recent study has shown that a red cell suspension prepared from frozen blood is effectively depleted of leucocyte and platelet con- tamination.4Nevertheless, our study has shown that the residual material can immunise the recipient against leucocyte and platelet on 16 July
Crackdown on locum doctors announced
Authors: J. Warden
Journal: BMJ (1997)

A new code of practice for employing locum doctors in British hospitals is intended to reduce the risk of incompetent or even bogus doctors being appointed.

The health minister, Alan Milburn, said: “The existing rules governing locum doctors are inadequate. In future all locum doctors will be screened to weed out those who are a danger …
Association of Atrial Natriuretic Peptide and Type A Natriuretic Peptide Receptor Gene Polymorphisms With Left Ventricular Mass in Human Essential Hypertension
Authors: Speranza Rubattu, Giada Bigatti, Anna Evangelista, Chiara Lanzani, Rosita Stanzione, Laura Zagato, Paolo Manunta, Simona Marchitti, Vanessa Venturelli, Giuseppe Bianchi, Massimo Volpe, Paola Stella
Journal: Journal of the American College of Cardiology (2006)
Abstract 44: Leukemia-associated DNMT3A R882 mutations and their role in anthracycline-induced DNA damage response and therapeutic resistance
Authors: Olga A. Guryanova, Kaitlyn Shank, Luisa Luciani, Evangelia Loizou, Matthew D. Keller, Abby R. Weinstein, Omar Abdel-Wahab, Siddhartha Mukherjee, Stephen S. Nimer, Ross L. Levine
Journal: Cancer Research (2014)

Abstract Despite significant advances in cancer research and treatment, therapeutic resistance remains a major obstacle for achieving stable remission in cancer patients. Acute myeloid leukemia (AML) is no exception, and most AML patients develop resistance to chemotherapy/targeted therapies, which results in disease relapse and progression. Recurrent mutations in the DNA methyltransferase 3A (DNMT3A) gene have been identified in 20-30% of AML cases and are predictive of unfavorable prognosis in patients treated with standard anti-leukemic regimens. In addition, DNMT3A-mutant AMLs appear to be relatively refractory to anthracycline family chemotherapeutics, such as daunorubicin. Half of all DNMT3A mutations affect amino acid residue R882, and recent work has shown that these mutants display decreased enzymatic activity and aberrant binding properties. In addition, previous studies have shown that wild-type DNMT3A functions as a pro-apoptotic switch in response to genotoxic stress induced by another anthracycline doxorubicin. We propose that mutant DNMT3A protects cells from apoptosis in response to DNA damage by altering molecular machinery involved in DNA-damage sensing, response and/or repair, through DNA methylation-dependent or independent mechanisms. Specifically, our data show that mutant DNMT3A affects recruitment of DNA repair proteins to chromatin, including aberrant distribution of homologous recombination marker RAD51. We are currently investigating molecular changes in DNA damage response in DNMT3A-mutant cells in vitro and ex vivo, and leukemogenic potential of the mutant Dnmt3a allele in vivo, whether alone or in combination with other cooperating oncogenes. Citation Format: Olga A. Guryanova, Kaitlyn Shank, Luisa Luciani, Evangelia Loizou, Matthew D. Keller, Abby R. Weinstein, Omar Abdel-Wahab, Siddhartha Mukherjee, Stephen S. Nimer, Ross L. Levine. Leukemia-associated DNMT3A R882 mutations and their role in anthracycline-induced DNA damage response and therapeutic resistance. [abstract]. In: Proceedings of the AACR Special Conference: Cancer Susceptibility and Cancer Susceptibility Syndromes; Jan 29-Feb 1, 2014; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(23 Suppl):Abstract nr 44. doi:10.1158/1538-7445.CANSUSC14-44
Cortisone and Corticotrophin in Ulcerative Colitis
Authors: S. C. Truelove, L. J. Witts
Journal: BMJ (1959)

A large-scale therapeutic trial carried out by the co-operation of physicians in five hospital regions during the period 1952-5 showed that cortisone was useful in increasing the chance of the patient being in remission within six weeks of starting medical treatment (Truelove and Witts, 1954, 1955).As judged by the overall clinical response *to treatment, the cortisone group enjoyed a
One-Year Risk for Advanced Colorectal Neoplasia: U.S. Versus U.K. Risk-Stratification Guidelines
Authors: María Elena Martínez*, Patricia Thompson, Karen Messer, Erin L. Ashbeck, David A. Lieberman, John A. Baron, Dennis J. Ahnen, Douglas J. Robertson, Elizabeth T. Jacobs, E. Robert Greenberg, Amanda J. Cross, Wendy Atkin*
Journal: Annals of Internal Medicine (2012)

Chinese translation Background: Guidelines from the United Kingdom and the United States on risk stratification after polypectomy differ, as do recommended surveillance intervals. Objective: To compare risk for advanced colorectal neoplasia at 1-year colonoscopy among patients cross-classified by U.S. and U.K. surveillance guidelines. Design: Pooled analysis of 4 prospective studies between 1984 and 1998. Setting: Academic and private clinics in the United States. Patients: 3226 postpolypectomy patients with 6- to 18-month follow-up colonoscopy. Measurements: Rates of advanced neoplasia (an adenoma ≥1 cm, high-grade dysplasia, >25% villous architecture, or invasive cancer) at 1 year, compared across U.S. and U.K. risk categories. Results: Advanced neoplasia was detected 1 year after polypectomy in 3.8% (95% CI, 2.7% to 4.9%) of lower-risk patients and 11.2% (CI, 9.8% to 12.6%) of higher-risk patients by U.S. criteria. According to U.K. criteria, 4.4% (CI, 3.3% to 5.4%) of low-risk patients, 9.9% (CI, 8.3% to 11.5%) of intermediate-risk patients, and 18.7% (CI, 14.8% to 22.5%) of high-risk patients presented with advanced neoplasia; U.K. high-risk patients comprised 12.1% of all patients. All U.S. lower-risk patients were low-risk by U.K. criteria; however, more patients were classified as low-risk, because the U.K. guidelines do not consider histologic features. Higher-risk U.S. patients were distributed across the 3 U.K. categories. Among all patients with advanced neoplasia, 26.3% were reclassified by the U.K. criteria to a higher-risk category and 7.0% to a lower-risk category, with a net 19.0% benefiting from detection 2 years earlier. Overall, substitution of U.K. for U.S. guidelines resulted in an estimated 0.03 additional colonoscopy every 5 years per patient. Limitations: Patients were enrolled 15 to 20 years ago, and quality measures for colonoscopy were unavailable. Patients lacking follow-up colonoscopy or with surveillance colonoscopy after 6 to 18 months and those with cancer or insufficient baseline adenoma characteristics were excluded (2076 of 5302). Conclusion: Application of the U.K. guidelines in the United States could identify a subset of high-risk patients who may warrant a 1-year clearing colonoscopy without substantially increasing rates of colonoscopy. Primary Funding Source: European Union Public Health Programme.
The half-life of RAG-1 protein in precursor B cells is increased in the absence of RAG-2 expression.
Authors: U Grawunder, D G Schatz, T M Leu, A Rolink, F Melchers
Journal: The Journal of Experimental Medicine (1996)

Site-specific recombination of immunoglobulin and T cell receptor gene segments in B and T lymphocytes is dependent on the expression of two recombinant activation genes, Rag-1 and Rag-2. Here, we show that RAG-1 protein turnover in pre-B cells depends on the expression of RAG-2. The apparent half-life of RAG-1 protein is increased when RAG-2 is not expressed in differentiating pre-B cells.
Paradoxic Effect of Ibuprofen on Neutrophil Accumulation in Pulmonary and Cutaneous Inflammation
Authors: Paul G. Hellewell, Scott K. Young, Peter M. Henson, G. Scott Worthen
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Evidence exists to suggest that the local accumulation of neutrophils in pulmonary inflammation occurs by a different mechanism than in other microvascular beds. In the present study, this suggestion was investigated using the nonsteroidal antiinflammatory drug ibuprofen. This drug was used because in addition to inhibiting cyclooxygenase, it prevents several aspects of neutrophil function, including adhesion. Local inflammation in the lung and skin of the same rabbits was induced by the administration of C5a, and the effect of intravenous injection of ibuprofen on the accumulation of neutrophils at these two sites was examined. In the skin, neutrophil accumulation was inhibited by ibuprofen, and this appeared to be independent of cyclooxygenase blockade. A possible mechanism was prevention of neutrophil adherence to endothelium in postcapillary venules, and in vitro experiments showed that ibuprofen could entirely prevent neutrophil adherence, in addition to suppressing azurophil granule secretion and Superoxide anion generation. However, the effect on adherence appeared to be independent of expression of the CD11/CD18 adhesion complex on the neutrophil. By contrast, in the pulmonary circulation of the same rabbit, C5a-induced neutrophil accumulation was enhanced by ibuprofen treatment. This was suggested to result from the prevention of thromboxane production, which normally serves to decrease local pulmonary blood flow to diminish delivery of neutrophils to the inflammatory site. Ibuprofen had no effect on retention of neutrophils in filters (models of pulmonary capillaries), suggesting that the drug was not enhancing the retention of neutrophils in capillaries on the first pass through the lung. Thus, it was possible that enhancement in the lung was caused by an increase in neutrophil supply. Because the accumulation of neutrophils in the skin is known to be dependent on the adherence phenomena, the paradoxic effects of ibuprofen on inflammation suggest that mechanisms responsible for the accumulation of neutrophils in cutaneous and pulmonary microcirculations are different.
Hookworm infestation of the small intestine: an unusual cause of obscure gastrointestinal bleeding
Authors: S. Yan, Y. Chu
Journal: Endoscopy (2007)

Hookworm is one the most common infections of humans, occurring in up to 740 million people [1]. The highest prevalence of hookworm occurs in sub-Saharan Africa, followed by Southeast Asia and the Indian subcontinent [2]. Hookworm infection in humans is caused by soil-transmitted helminths, mostly Ancylostoma duodenale and Necator americanus. Patients with a light hookworm infection are usually asymptomatic, but a moderate or heavy hookworm burden can result in nausea, fatigue, palpitations, and recurrent abdominal pain [3]. The most common laboratory findings are eosinophilia and iron deficiency anemia resulting from chronic occult blood loss [1] [3]. However, patients with hookworm infection may present with acute massive gastrointestinal bleeding [4]. Furthermore, the degree of anemia depends on hookworm burdens and the species, because A. duodenale causes more blood loss than N. americanus [1] [3].
Chronomodulated Versus Fixed-Infusion—Rate Delivery of Ambulatory Chemotherapy With Oxaliplatin, Fluorouracil, and Folinic Acid (Leucovorin) in Patients With Colorectal Cancer Metastases: a Randomized Multi-institutional Trial
Authors: Francis A. Lévi, Rachid Zidani, Jean-Michel Vannetzel, Bruno Perpoint, Christian Focan, Roberto Faggiuolo, Philippe Chollet, Carlo Garufi, Moshe Itzhaki, Luigi Dogliotti, Stefano lacobelli, René Adam, Francis Kunstlinger, Julio Gastiaburu, Henri Bismuth, Claude Jasmin, Jean-Louis Misset
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Chronomodulated Versus Fixed-Infusion—Rate Delivery of Ambulatory Chemotherapy With Oxaliplatin, Fluorouracil, and Folinic Acid (Leucovorin) in Patients With Colorectal Cancer Metastases: a Randomized Multi-institutional Trial Get access Francis A. Lévi, Francis A. Lévi Search for other works by this author on: Oxford Academic PubMed Google Scholar Rachid Zidani, Rachid Zidani Search for other works by this author on: Oxford Academic PubMed Google Scholar Jean-Michel Vannetzel, Jean-Michel Vannetzel Search for other works by this author on: Oxford Academic PubMed Google Scholar Bruno Perpoint, Bruno Perpoint Search for other works by this author on: Oxford Academic PubMed Google Scholar Christian Focan, Christian Focan Search for other works by this author on: Oxford Academic PubMed Google Scholar Roberto Faggiuolo, Roberto Faggiuolo Search for other works by this author on: Oxford Academic PubMed Google Scholar Philippe Chollet, Philippe Chollet Search for other works by this author on: Oxford Academic PubMed Google Scholar Carlo Garufi, Carlo Garufi Search for other works by this author on: Oxford Academic PubMed Google Scholar Moshe Itzhaki, Moshe Itzhaki Search for other works by this author on: Oxford Academic PubMed Google Scholar Luigi Dogliotti, Luigi Dogliotti Search for other works by this author on: Oxford Academic PubMed Google Scholar ... Show more Stefano lacobelli, Stefano lacobelli Search for other works by this author on: Oxford Academic PubMed Google Scholar René Adam, René Adam Search for other works by this author on: Oxford Academic PubMed Google Scholar Francis Kunstlinger, Francis Kunstlinger Search for other works by this author on: Oxford Academic PubMed Google Scholar Julio Gastiaburu, Julio Gastiaburu Search for other works by this author on: Oxford Academic PubMed Google Scholar Henri Bismuth, Henri Bismuth Search for other works by this author on: Oxford Academic PubMed Google Scholar Claude Jasmin, Claude Jasmin Search for other works by this author on: Oxford Academic PubMed Google Scholar Jean-Louis Misset Jean-Louis Misset Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 21, 2 November 1994, Pages 1608–1617, https://doi.org/10.1093/jnci/86.21.1608 Published: 02 November 1994 Article history Received: 13 December 1993 Revision received: 08 July 1994 Accepted: 08 September 1994 Published: 02 November 1994
Impact of left ventricular structure on the incidence of hypertension. The Framingham Heart Study.
Authors: W S Post, M G Larson, D Levy
Journal: Circulation (1994)

BACKGROUND Left ventricular hypertrophy is often found very early in the course of hypertension. It is not known whether increased left ventricular mass contributes to the pathogenesis of hypertension. The purpose of this study was to examine the impact of left ventricular mass and other echocardiographically assessed cardiac structural features on the incidence of hypertension. METHODS AND RESULTS Subjects for this investigation included participants in the Framingham Heart Study and the Framingham Offspring Study who were normotensive at the baseline examination (systolic blood pressure, &lt; 140 mm Hg; diastolic blood pressure, &lt; 90 mm Hg; not receiving antihypertensive medications) and free of coronary heart disease, congestive heart failure, valvular heart disease, hypertrophic cardiomyopathy, diabetes mellitus, and renal insufficiency. The study sample included 1121 men (mean age, 44.4 years) and 1559 women (mean age, 45.6 years). Four years after the baseline examination, 202 men (18.0%) and 257 women (16.5%) were hypertensive (systolic blood pressure, &gt; or = 140 mm Hg; diastolic blood pressure, &gt; or = 90 mm Hg; or use of antihypertensive medications). Baseline echocardiographic left ventricular mass (P = .01) and the sum of septal and posterior left ventricular wall thicknesses (P = .02) were associated with progression to hypertension. After adjusting for sex, baseline age, systolic and diastolic blood pressures, body mass index, alcohol intake, and systolic blood pressure from an examination 8 years earlier, the odds ratio for developing hypertension for a 1-SD increment in left ventricular mass index was 1.20 (95% confidence interval, 1.04 to 1.39), and the odds ratio for a 1-SD increment in left ventricular wall thickness was 1.16 (95% confidence interval, 1.02 to 1.33). CONCLUSIONS In these normotensive adults, increased left ventricular mass and wall thickness were associated with the development of hypertension. Further studies are warranted to examine the utility of echocardiography in determining the need for antihypertensive therapy and to assess the effect of earlier intervention on the course of progression to hypertension.
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia
Authors: Hsin-Yu Fang, Russell Hughes, Craig Murdoch, Seth B. Coffelt, Subhra K. Biswas, Adrian L. Harris, Randall S. Johnson, Hongxia Z. Imityaz, M. Celeste Simon, Erik Fredlund, Florian R. Greten, Jordi Rius, Claire E. Lewis
Journal: Blood (2009)