Long-Term Effects of Low-Carbohydrate Versus Low-Fat Diets in Obese Persons
Authors: Marion L. Vetter
Journal: Annals of Internal Medicine (2010)

Letters2 March 2010Long-Term Effects of Low-Carbohydrate Versus Low-Fat Diets in Obese PersonsMarion L. Vetter, MD, RD, Nayyar Iqbal, MD, MSCE, Cornelia Dalton-Bakes, BS, Sheri Volger, MS, RD, and Thomas A. Wadden, PhDMarion L. Vetter, MD, RDFrom Hospital of the University of Pennsylvania, Philadelphia Veterans Affairs Medical Center, and University of Pennsylvania School of Medicine, Philadelphia, PA 19104.Search for more papers by this author, Nayyar Iqbal, MD, MSCEFrom Hospital of the University of Pennsylvania, Philadelphia Veterans Affairs Medical Center, and University of Pennsylvania School of Medicine, Philadelphia, PA 19104.Search for more papers by this author, Cornelia Dalton-Bakes, BSFrom Hospital of the University of Pennsylvania, Philadelphia Veterans Affairs Medical Center, and University of Pennsylvania School of Medicine, Philadelphia, PA 19104.Search for more papers by this author, Sheri Volger, MS, RDFrom Hospital of the University of Pennsylvania, Philadelphia Veterans Affairs Medical Center, and University of Pennsylvania School of Medicine, Philadelphia, PA 19104.Search for more papers by this author, and Thomas A. Wadden, PhDFrom Hospital of the University of Pennsylvania, Philadelphia Veterans Affairs Medical Center, and University of Pennsylvania School of Medicine, Philadelphia, PA 19104.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-5-201003020-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: We reported elsewhere (1) the results of a randomized, controlled trial that found greater weight loss at 6 months with a low-carbohydrate diet (<30 g/d) than with a calorie-restricted, low-fat diet (deficit of 500 kcal/d with <30% kcal from fat) in 132 participants with a mean weight of 130.9 kg (SD, 25.2) and a high prevalence of diabetes and the metabolic syndrome. We subsequently reported (2) no significant differences in weight loss between groups at the end of the trial (12 months).Objective: To assess outcomes after 36 months.Methods: No further intervention occurred after 12 months. At 36 ...References1. Samaha FF, Iqbal N, Seshadri P, Chicano KL, Daily DA, McGrory J, et al. A low-carbohydrate as compared with a low-fat diet in severe obesity. N Engl J Med. 2003;348:2074-81. [PMID: 12761364] CrossrefMedlineGoogle Scholar2. Stern L, Iqbal N, Seshadri P, Chicano KL, Daily DA, McGrory J, et al. The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. Ann Intern Med. 2004;140:778-85. [PMID: 15148064] LinkGoogle Scholar3. Sacks FM, Bray GA, Carey VJ, Smith SR, Ryan DH, Anton SD, et al. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med. 2009;360:859-73. [PMID: 19246357] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Marion L. Vetter, MD, RD; Nayyar Iqbal, MD, MSCE; Cornelia Dalton-Bakes, BS; Sheri Volger, MS, RD; Thomas A. Wadden, PhDAffiliations: From Hospital of the University of Pennsylvania, Philadelphia Veterans Affairs Medical Center, and University of Pennsylvania School of Medicine, Philadelphia, PA 19104.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Effects of Low-Carbohydrate versus Conventional Weight Loss Diets in Severely Obese Adults: One-Year Follow-up of a Randomized Trial Linda Stern , Nayyar Iqbal , Prakash Seshadri , Kathryn L. Chicano , Denise A. Daily , Joyce McGrory , Monica Williams , Edward J. Gracely , and Frederick F. Samaha Metrics Cited byNutritional Interventions: Diet Modifications, Nutritional Supplements, Complementary and Alternative MedicineNutritional Management of Type 2 Diabetes Mellitus and Obesity and Pharmacologic Therapies to Facilitate Weight LossVery-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trialsMedical Weight ManagementGlycemic IndexLifestyle Modifications and Surgical Options in the Treatment of Patients with Obesity and Type 2 Diabetes MellitusAssessment and Treatment of Excess WeightTreatment of lipid disorders in obesityDietary protein and risk of ischemic heart disease in middle-aged menDietary Approaches to Obesity 2 March 2010Volume 152, Issue 5Page: 334-335KeywordsCarbohydratesDietInsulin resistanceLipidsMetabolic syndromeOverweightRacial and ethnic issuesRandomized trialsSleep apneaWeight loss ePublished: 2 March 2010 Issue Published: 2 March 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...