The Possible Role of Porins in Bacterial Antibiotic Resistance
Authors: LAURENT GUTMANN
Journal: Annals of Internal Medicine (1984)

Editorials1 October 1984The Possible Role of Porins in Bacterial Antibiotic ResistanceLAURENT GUTMANN, M.D., RUSSELL WILLIAMSON, PH.D., EKKEHARD COLLATZ, M.D.LAURENT GUTMANN, M.D.Search for more papers by this author, RUSSELL WILLIAMSON, PH.D.Search for more papers by this author, EKKEHARD COLLATZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-4-554 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAntibiotic agents are thought to diffuse freely through the cell wall of gram-positive bacteria. However, in gram-negative bacteria the diffusion of a given antibiotic agent depends on the permeability of the outer membrane. This permeability is determined by the particular structure of the membrane, which is composed of proteins and an asymmetric lipid bilayer. The outer layer consists mainly of lipopolysaccharides and the inner layer of phospholipids (1). Some outer membrane proteins are attached to the underlying peptidoglycan. This membrane structure allows for different pathways of diffusion into the periplasmic space. Hydrophobic molecules are normally excluded, but may diffuse through...References1. NIKAIDONAKAE HT. The outer membrane of Gram-negative bacteria. Adv Microb Physiol. 1979;20:163-250. CrossrefMedlineGoogle Scholar2. NAKAE T. Identification of the outer membrane protein of E. coli that produces transmembrane channels in reconstituted vesicle membranes. Biochem Biophys Res Commun. 1976;71:877-84. CrossrefMedlineGoogle Scholar3. NIKAIDOLUCKEYROSENBERG HME. Nonspecific and specific diffusion channels in the outer membrane of Escherichia coli. J Supramol Struct. 1980;13:305-13. CrossrefMedlineGoogle Scholar4. VAN ALPHENVAN BOXTELVAN SELMLUGTENBERG WRNB. 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HOOPER, M.D.Bêta-lactamases : identification, rôle, aspects épidémiologiquesGenetic and biochemical characterization of norfloxacin resistance in Escherichia coli 1 October 1984Volume 101, Issue 4Page: 554-557KeywordsAntibiotic resistanceAntibioticsCell wallsGram negative bacteriaGram positive bacteriaLipidsMembrane proteinsOuter membrane proteinsPhospholipidsProtein structure Issue Published: 1 October 1984 PDF downloadLoading ...