tbuckley/cabot-search huggingface dataset:
Leukemic Gingival Infiltration
Authors: Aparna Mani, David A Lee
Journal: New England Journal of Medicine (2008)

An otherwise healthy 36-year-old man presented with a 6-day history of bleeding gums and abdominal pain in the left upper quadrant. He reported having had fevers, fatigue, decreased appetite, and unintentional weight loss of 10 lb (4.5 kg) during the previous month. On physical examination, red, swollen gingivae (Panel A), tender submandibular lymph nodes, and a palpable spleen were noted. Laboratory evaluation revealed a peripheral-blood white-cell count of 194,100 per cubic millimeter, with 44% blasts, and a peripheral-blood platelet count of 12,000 per cubic millimeter. Examination of a bone marrow–biopsy specimen showed acute myelomonocytic leukemia with dysplastic eosinophils with a . . .
Asylum seekers and undocumented migrants must retain access to primary care
Authors: P. d. Zulueta
Journal: BMJ (2011)

They come singly or in huddled clusters, subdued, their eyes downcast, their shoulders stooped. They tell us tales of loss, of devastation, of living in the shadows, always fearful of exposing themselves to bureaucratic scrutiny. They sleep, if lucky, on the sofas of friends or in hostels, otherwise in doorways, on park benches, or in churches and bus stations. They are like Dante’s lost souls, wafting in limbo, neither in heaven nor hell, but in a cold and lifeless purgatory, a place the world refuses to acknowledge.

They tell me their stories, their faces etched with suffering, their eyes reflecting dull despondency or despair. And yet I am humbled by their grace, dignity, and endurance. Somehow they manage to look clean, orderly, and well presented. The tell tale sign may just be the tightly clutched plastic bag. That bag may hold all their possessions, including documents such as a dog eared letter, years old, from the Home Office, blandly reporting information about the status of their asylum appeal. Many of them have …
FRI0540 Correlation between the European Consensus Lupus Activity Measurement (ECLAM) and the Modified Systemic Lupus Erythematosus Disease Activity Index 2000 (M-SLEDAI 2K) in Juvenile Systemic Lupus Erythematosus (JSLE)
Authors: J.O. Sato, J.E. Corrente, C.S. Magalhães
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> There are valid tools to measure disease activity and damage in JSLE, but to date there is no gold standard. <h3>Objectives</h3> To test the correlation between two activity indices, the M-SLEDAI-2K and ECLAM, and their respective correlation to the Pediatric SLICC/ACR Damage Index (Ped-SDI) during standard care of JSLE patients. <h3>Methods</h3> M-SLEDAI-2K is a variant of the original SLEDAI-2K where a-DNA and complement testing is suppressed for feasibility of standard approach (Uribe et al., 2004). It has not been previously tested in JSLE. The tools were retrospectively scored during follow up and summarized by adjusted means and area under the curve (AUC). The Pediatric SLICC/ACR Damage Index (Ped-SDI) was scored during the last visit and only after the first year of follow up. Pearson correlation between the M-SLEDAI-2K and ECLAM and Spearman correlation between the M-SLEDAI-2K and ECLAM, respectively to Ped-SDI were calculated. ROC analysis tested discriminating properties of both activity indices in relation to Ped-SDI damage scores. <h3>Results</h3> Thirty seven patients with 11.2 years median age at diagnosis and 2.7 years median follow up were scored during 781 visits. The M-SLEDAI-2K and ECLAM adjusted means were highly correlated (r Pearson =0.78 and p&lt;0.0001; Figure 1). Similarly, a strong correlation was found for both at disease presentation and throughout disease course (r Spearman &gt;0.7 and p&lt;0.001). Correlation between the M-SLEDAI-2K and ECLAM respectively to Ped-SDI was moderate. Their respective ROC AUC were 0.74 and 0.73, and cutoff points of 3.62 and 1.28, discriminating Ped-SDI. <h3>Conclusions</h3> The strong correlation between the M-SLEDAI-2K and ECLAM on retrospective approach indicated that both tools may be equally useful for JSLE activity measure in clinical practice. <h3>References</h3> Uribe AG, Vilá LM, McGwin G Jr, Sanchez ML, Reveille JD, Alarcόn GS. The Systemic Lupus Activity Measure-revised, the Mexican Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus. J Rheumatol 2004; 31: 1934-40. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4135
697 PRECISE AND SIMPLE QUANTITATION OF LIVER STEATOSIS BY MRI IN AN ANIMAL MODEL AND IN PATIENTS WITH NAFLD
Authors: E. Cesbron-Metivier, C. Jarlot, V. Roullier, J. Boursier, C. Cavaro-Menard, J. Lebigot, S. Michalak, P. Cales, C. Aube
Journal: Journal of Hepatology (2009)
New Evidence Supports, Challenges, and Informs the Ambitions of Health Reform
Authors: Aaron E. Carroll, Austin B. Frakt
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Impact of the Micro-Lightguide O2C for the Quantification of Tissue Ischemia in Diabetic Foot Ulcers
Authors: Stefan Beckert, Maria B. Witte, Alfred Königsrainer, Stephan Coerper
Journal: Diabetes Care (2004)

OBJECTIVE—Tissue oxygen supply is crucial for wound healing. Especially in diabetic foot lesions, the chances for healing are mainly dependent on the presence or absence of ischemia. This study investigates the impact of the tissue O2 analysis system “O2C” for noninvasive quantification of tissue oxygenation in diabetic foot ulcer patients. RESEARCH DESIGN AND METHODS—O2C assessed relative blood flow (flow), flow velocity (velo), and hemoglobin concentration (rHb) and hemoglobin oxygenation (SO2) at 2 and 6 mm depth (means ± SE). 1) Measurements were performed on intact skin of the forefoot and forearm of 20 healthy volunteers on 2 consecutive days. 2) Parameters were assessed on intact skin of the forefoot of diabetic foot ulcer patients (n = 14). 3) Measurements were performed directly at the wound site in diabetic patients (n = 14). RESULTS—1) Flow, velo, rHb, and SO2 at 2 and 6 mm depth were not significantly different when measured at 2 consecutive days. 2) There were no significant differences between diabetic subjects and healthy volunteers. Only flow in 6 mm depth was significantly higher in diabetic subjects (75 ± 13 vs. 51 ± 0.4 arbitrary units [AU], P &amp;lt; 0.05). When diabetic foot ulcer patients were split into healers and nonhealers, initial readings of SO2 at 2 mm (32 ± 6 vs. 44 ± 3%, P &amp;lt; 0.05) and flow in 6 mm (28 ± 1 vs. 51 ± 0.6 AU, P &amp;lt; 0.05) were significantly reduced in nonhealers compared with control subjects, whereas in healers flow in 6 mm (70 ± 0.6 vs. 51 ± 0.6 AU, P &amp;lt; 0.05) was significantly higher than that in control subjects. 3) Initial SO2, rHb, flow, and velo were significantly lower in nonhealing compared with healing wounds. CONCLUSIONS—O2C is a new reliable and valid method for noninvasive measurement of tissue oxygenation and microvascular blood flow in patients with diabetic foot ulcers.
An Environmental Odyssey: People, Pollution, and Politics in the Life of a Practical Scientist
Authors: Clark W. Heath
Journal: JAMA (1991)

In the 1930s, occupational health work in the United States centered in insurance companies whose interests lay with reducing workers' compensation costs arising from industrial health hazards. As a young industrial hygienist working for such a company in New York, Merril Eisenbud began his career in environmental health. None of the laws and agencies yet existed that are now in place to protect the environment and to govern the fields of environmental and occupational health. Our national awareness of the hazards associated with an expanding industrial society had yet to be aroused. Now, more than 50 years later, Eisenbud has written this engaging autobiographical account, which not only traces the growth of one man's lifework but in the process also provides a vivid and personalized history of this country's efforts to cope with fast-changing and complicated needs in environmental health. As happens in many lives, his career, like Odysseus' travels,
Effect of Acetazolamide and AutoCPAP Therapy on Breathing Disturbances Among Patients With Obstructive Sleep Apnea Syndrome Who Travel to Altitude
Authors: Tsogyal D. Latshang, Yvonne Nussbaumer-Ochsner, Rahel M. Henn, Silvia Ulrich, Christian M. Lo Cascio, Bruno Ledergerber, Malcolm Kohler, Konrad E. Bloch
Journal: JAMA (2012)

APNEAsyndrome (OSA) is a highly prevalent disease affecting at least 2% to 4% of middle-aged adults in Western countries. 1Patients with OSA experience excessive sleepiness, cognitive impairment, and other symptoms that impair quality of life.3][4] Nocturnal application of continuous positive airway pressure (CPAP) is currently the most effective therapy. 5s travel to the mountains for professional and recreational activities is increasingly popular, involving millions of persons worldwide, the estimated number of patients with OSA among mountain tourists is also very high, several hundred thousand to several million persons each year (eAppendix, available at http://www.jama.com).Recently, we reported that untreated patients with OSA living at low altitude (Ͻ800 m above sea
High-Grade KIT-Negative Sarcoma of the Small Bowel in a Patient With Chronic Myeloid Leukemia Receiving Long-Term Tyrosine Kinase Inhibitors
Authors: Josef Martz, Sarika Jain, Linda T. Vahdat, Lihui Qin, Juan Miguel Mosquera, Cristina R. Antonescu, Elizabeta C. Popa
Journal: Journal of Clinical Oncology (2013)

Case ReportA 65-year-old man with a history of hypertension, hypercholesterolemia, and peripheral vascular disease was diagnosed with chronic phase chronic myeloid leukemia (CML) in 1998.He was treated with interferon and cytarabine, which resulted in a complete cytogenetic remission.In August 2000, imatinib (Gleevec; Novartis, East Hanover, NJ) at a dose of 400 mg per day was started for cytogenetic relapse.Complete cytogenetic remission was achieved after 3 months of therapy.Ten years later, cytogenetic relapse reoccurred and imatinib dosing was increased to 800 mg, and then was discontinued shortly thereafter because of adverse effects.Therapy was changed to nilotinib (Tasigna; Novartis) at a dose of 400 mg twice per day.Eleven months later, the patient developed leg cramps and weakness that were attributed to nilotinib, which was discontinued and replaced with dasatinib (Sprycel; Bristol-Myers Squibb, Princeton, NJ) at a dose of 100 mg once per day.The patient experienced intermittent abdominal pain during the ensuing 4 months, which culminated in hospitalization for upper GI bleeding.Computed tomography (CT) enterography was performed and revealed an enhancing polypoid mass (Fig 1, arrow) at the duodenojejunal junction and retroperitoneal lymphadenopathy.Esophagogastroduodenoscopy demonstrated a medium-sized hemorrhagic mass in the third part of the duodenum.Endoscopic biopsy revealed a poorly differentiated high-grade malignancy of unknown origin, located mainly in the submucosa.Immunohistochemical staining was positive for vimentin and nega-
Acne and tetracycline
Authors: J. A. Savin
Journal: British Journal of Dermatology (1967)

Journal Article Acne and tetracycline Get access J. A. Savin J. A. Savin St. George? Hospital, Tooting Grove, London S.W.17 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 79, Issue 7, 1 July 1967, Page 426, https://doi.org/10.1111/j.1365-2133.1967.tb11526.x Published: 01 July 1967
Cutaneous keratocyst in naevoid basal cell carcinoma syndrome
Authors: E. BASELGA, W.W. DZWIERZYNSKI, M. NEUBURG, J.L. TROY, N.B. ESTERLY
Journal: British Journal of Dermatology (1996)

We report a patient with naevoid basal cell carcinoma syndrome (NBCCS) who developed cutaneous cysts on her digits. Histological examination of one of the cysts showed a festooned lining epithelium maturing without a granular cell layer, similar to that of the jaw keratocyst characteristic of this syndrome. This type of cutaneous keratocyst has been reported only once previously. in two patients with NBCCS.
The Rationale for Placebo-Controlled Trials: Methodology and Policy Considerations
Authors: Franklin G. Miller
Journal: The American Journal of Bioethics (2009)

"The Rationale for Placebo-Controlled Trials: Methodology and Policy Considerations." The American Journal of Bioethics, 9(9), pp. 49–50 This article is not subject to U.S. Copyright Law The opinions expressed are the views of the author and do not necessarily reflect the policy of the National Institutes of Health, the Public Health Service, or the United States Department of Health and Human Services. This research was supported by the Intramural Research Program of the Clinical Center, National Institutes of Health.
The Gastrointestinal Tract
Authors: David R. Dantzker
Journal: JAMA (1993)

Despite advances in diagnosis and treatment, the survival of patients admitted to a critical care unit remains disappointingly low. Too many patients die each year as a result of irreversible organ failure, and too many survivors suffer prolonged disabilities. At least some of this organ damage can be attributed to the development of tissue hypoxia and is potentially preventable. This remains one of the major challenges for critical care physicians. See also p 1203. The process of oxygen delivery from the environment to the tissue is complex. The first step in the process, oxygenation of the arterial blood, is well understood and can usually be adequately achieved, even in the sickest patient. The development of techniques to improve oxygenation of the arterial blood was clearly dependent on the development of effective ways to monitor the arterial PO2. Repeated measurement of arterial blood gases is routine in critically ill patients, and
Kawasaki Disease in an Adult
Authors: Gordon A. Caron
Journal: JAMA (1980)

<h3>To the Editor.—</h3> The recent report of mucocutaneous lymph node syndrome (Kawasaki disease) in adults by E. Dale Everett, MD (242:542, 1979), prompted the retrospective identification of a recent, previously undiagnosed case in a 22-year-old woman. <h3>Report of a Case.—</h3> Previously healthy, the patient woke with a fever and vomited. Malaise, chills, and a temperature of from 38 to 40 °C continued for 36 hours, when a sore throat and a generalized nonitching rash developed on the limbs and trunk. On examination the woman appeared ill; she was slightly drowsy, with a temperature of 40 °C and large submandibular lymph nodes, diffuse edema of the uvula, and erythema of the pharynx without exudate. The lips were red and chapped. There was an extensive scarlatiniform rash on the abdomen and limbs without marked accentuation in the flexures. The spleen was not enlarged; no other lymph nodes were felt, and the neck
Implications of histologically reported residual tumour on the bronchial margin after resection for bronchial carcinoma.
Authors: M R Law, M E Hodson, S C Lennox
Journal: Thorax (1982)

A group of 64 cases with histologically reported residual tumour on the bronchial margin after resection for bronchial carcinoma has been examined. Carcinoma in situ of the bronchial mucosa was described in nine cases, invasive carcinoma of the bronchial mucosa in 29, peribronchial malignancy in 18, and lymphatic permeation in eight. Survival with peribronchial malignancy and lymphatic permeation was poor. Nevertheless, the finding of earlier workers that residual mucosal tumour at the margin of the resected bronchus may not adversely affect survival has been confirmed. The reason for the prolonged survival of some patients despite reported tumours of the bronchial stump mucosa may be that such reports are sometimes artefactual, and two possible mechanisms for this are discussed.
Fructose for Dialysis
Authors: MICHAEL ROBSON
Journal: Annals of Internal Medicine (1971)

Letters, Comments, and Corrections1 December 1971Fructose for DialysisMICHAEL ROBSON, M.D., JOSEPH B. ROSENFELD, M.D.MICHAEL ROBSON, M.D.Search for more papers by this author, JOSEPH B. ROSENFELD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-6-975_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dr. Tenckhoff drew attention in the August issue (Ann Intern Med75:313-314, 1971) to some hazards of peritoneal dialysis with hypertonic solutions, in particular, hypernatremia, hyperglycemia, and hyperosmolar coma. In view of his observations about sorbital, which has been found to be unsatisfactory, we should like to draw attention to the use of 4½ % fructose solutions as a substitute for glucose (1). When a group of patients undergoing dialysis with 4½ % fructose were compared with a similar group using 4½ % glucose, there was no significant rise in the osmolarity of the fructose group, and...Reference1. ROBSONLEVIROSENFELD MJJ: Hyperglycemia and hyperosmolarity in peritoneal dialysis: its prevention by the use of fructose. Proc Eur Dial Transplant Assoc 6:300, 1969 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MICHAEL ROBSON, M.D.; JOSEPH B. ROSENFELD, M.D.Affiliations: Renal Unit Beilinson Medical Center Tel-Aviv University Medical School Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPractical Use of Peritoneal DialysisAdding Glucose to Dialysate: Pros and ConsPeritoneal DialysisDANGERS OF INTRAVENOUS FRUCTOSE 1 December 1971Volume 75, Issue 6Page: 975-976KeywordsComaFructosesGlucoseHyperglycemiaHypernatremiaMedical dialysisPeritoneal dialysis ePublished: 1 December 2008 Issue Published: 1 December 1971 PDF downloadLoading ...
Value of Endoscopic Ultrasonography for Assessment of Patients Presenting Elevated Tumor Marker Levels after Surgery for Colorectal Cancers
Authors: M. Giovannini, D. Bernardini, J. F. Seitz, V. Moutardier, G. Hoevenaeghel, G. Monges, J. R. Delpero
Journal: Endoscopy (1998)

This prospective study was undertaken to evaluate the role of endoscopic ultrasound (EUS) in patients presenting with elevated tumor marker levels (CEA, CA 19-9) after surgery for colorectal cancer.During a 26-month period, colonic EUS was performed in 21 patients who had undergone surgical treatment for colorectal cancers. All patients presented with elevated tumor marker levels at the time of examination but all other diagnostic procedures (US, CT scan of the abdomen and thorax, bone scintigraphy and colonoscopy) did not demonstrate recurrence. Colonic EUS was performed using a linear convex probe (echoendoscopes Pentax: FG 32 UA, 36 U, 38 UX). In cases with normal findings on colonic EUS, upper gastrointestinal tract EUS was also performed.21 colonic EUS and six upper gastrointestinal tract EUS examinations were performed. Of 21 colonic EUS examinations, 15 showed either local recurrence (n = 9) or peritoneal carcinomatosis (n = 6) and six EUS-guided biopsies were performed. Of these 15 patients, 13 were operated on and results were confirmed in 12 of 13 patients, namely in 8/9 cases with suspected anastomotic recurrence and in all four operated cases with presumed peritoneal carcinomatosis. EUS-guided biopsy had diagnosed three of the four cases before. Upper GI EUS was performed in the six cases with normal colonic EUS; two cases showed mediastinal lymph nodes and one showed celiac lymph nodes. EUS-guided biopsy confirmed the malignancy of these nodes. For the diagnosis of recurrence, sensitivity, specificity and accuracy of lower plus upper gastrointestinal EUS were 94.4%, 66.6% and 90.4% respectively.EUS of the colon and--in selected cases--also of the upper gastrointestinal tract is quite useful in this clinical setting. Further studies are needed to evaluate the impact of EUS on outcome in larger patient numbers.
Reasons to Encourage Smoking
Authors: Ervin Epstein
Journal: JAMA (1976)

<h3>To the Editor.—</h3> I was very disappointed that Dr Lowitz neglected to mention the most important reason for encouraging smoking (235: 804, 1976). It is obvious that cancer is good for you. It is the greatest advancement ever in preventive medicine, since it prevents old age, senility, arteriosclerosis, strokes, loss of memory, and other debilitations. I am certain that Dr Lowitz is anxious to have this oversight corrected.
Partial Liquid Ventilation in Adult Patients with Acute Respiratory Distress Syndrome
Authors: Robert M. Kacmarek, Herbert P. Wiedemann, Philip T. Lavin, Mark K. Wedel, Ahmet S. Tütüncü, Arthur S. Slutsky
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Section:ChooseTop of pageAbstract <<METHODSRESULTSDISCUSSIONAPPENDIX 1APPENDIX 2APPENDIX 3ReferencesCITING ARTICLES
Dynamic Spectral Imaging: Improving Colposcopy
Authors: William P. Soutter, Emmanuel Diakomanolis, Deirdre Lyons, Sadaf Ghaem-Maghami, Tosin Ajala, Dimitrios Haidopoulos, Dimitrios Doumplis, Costas Kalpaktsoglou, Gerasimos Sakellaropoulos, Suzan Soliman, Karen Perryman, Vicky Hird, C. Hilary Buckley, Kitty Pavlakis, Sofia Markaki, Roberto Dina, Vourneen Healy, Costas Balas
Journal: Clinical Cancer Research (2009)

Abstract Purpose: Colposcopy occupies a key role in the prevention of cervical cancer by identifying preinvasive or invasive lesions. However, colposcopy is subjective and is responsible for 52% of screening failures. Dynamic spectral imaging (DSI) is based on the objective, quantitative assessment of the acetowhitening effect. This study compared DSI with colposcopy. Experimental Design: Women referred for colposcopy were examined simultaneously with colposcopy and DSI using a precommercial DySIS model (FPC-03) in an international, multicenter trial. The colposcopy impression and DySIS values were compared with consensus histology reports of biopsies. Subjects were recruited to a training group and subsequently to a test group. Measures were taken to avoid verification bias. Results: The training and test groups comprised 82 and 308 eligible women, respectively. A cutoff value to identify high-grade disease was selected from the results of the training group and data from previous work. Receiver operator curve analysis of the test data showed an area under the curve of 0.844. DySIS detected 62.9% more high-grade cases than colposcopy (57 versus 35, P = 0.0001). DySIS exceeded end points approved by the Food and Drug Administration for similar studies, with increments in the true positive rate of 22/308 (7.1%; lower 95% CL, 4.5% versus 2%) and in the false positive rate of 32/308 (10.4%; upper 95% CL, 14.7% versus 15%). Conclusions: DySIS is more sensitive than colposcopy in detecting high-grade lesions and can provide improved guidance for biopsy. The results are obtained in a user-independent fashion, making it suitable for use by nursing personnel.