Autoimmune Chronic Hepatitis Exacerbated by Alpha-Interferon
Authors: Thomas Papo, Patrick Marcellin, Jacques Bernuau, François Durand, Thierry Poynard, Jean-Pierre Benhamou
Journal: Annals of Internal Medicine (1992)

Brief Reports1 January 1992Autoimmune Chronic Hepatitis Exacerbated by Alpha-InterferonThomas Papo, MD, Patrick Marcellin, MD, Jacques Bernuau, MD, François Durand, MD, Thierry Poynard, MD, Jean-Pierre Benhamou, MDThomas Papo, MD, Patrick Marcellin, MD, Jacques Bernuau, MD, François Durand, MD, Thierry Poynard, MD, Jean-Pierre Benhamou, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-1-51 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlpha-interferon is known to reduce viral replication, to normalize aminotransferase levels, and to reduce hepatic lesions in 40% of patients with chronic hepatitis caused by hepatitis C virus (HCV) infection (1). Alpha-interferon is also known to induce exacerbation of various autoimmune disorders (2). We describe three patients with type-1 autoimmune chronic hepatitis, erroneously diagnosed as chronic hepatitis C, in whom alpha-interferon administration resulted in aggravation of liver disease.Case ReportsCase 1A 20-year-old man complained of nausea and fatigue in February 1988. The alanine aminotransferase (ALT) level was 26.6 μkat/L (normal, 0 to 0.58 μkat/L). The bilirubin level was...References1. DavisBalartSchiffLindsayBodenheimerPerrillo GLEKHR. Treatment of chronic hepatitis C with recombinant interferon alpha. N Engl J Med. 1989:321:1501-6. CrossrefMedlineGoogle Scholar2. RonnblomAlmOberg LGK. Autoimmunity after alpha-interferon therapy for malignant carcinoid tumors. Ann Intern Med. 1991:115:178-83. LinkGoogle Scholar3. HombergAbuafBernardIslamAlvarezKhalil JNOSFS. Chronic active hepatitis associated with antiliver/kidney microsome antibody type 1: a second type of "autoimmune" hepatitis. Hepatology. 1987;7:1333-9. CrossrefMedlineGoogle Scholar4. VentoDi PerriGarofanoCoscoConciaFerraroBassetti SGTLETD. Hazards of interferon therapy for HBV-seronegative chronic hepatitis [Letter]. Lancet. 1989;2:926. CrossrefMedlineGoogle Scholar5. MayetHessGerkenRossolVothManns WGGSRM. Treatment of chronic type B hepatitis with recombinant alpha-interferon induces autoantibodies not specific for autoimmune chronic hepatitis. Hepatology. 1989:10:24-8. CrossrefMedlineGoogle Scholar6. BottazzoPujol-BorrellHanafusaFeldmann GRTM. Role of HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet 1983:2:1115-8. CrossrefMedlineGoogle Scholar7. LenziBallardiniFusconiCassaniSelleriVolta MGMFLU. Type 2 autoimmune hepatitis and hepatitis C virus infection. Lancet. 1990:335:258-9. CrossrefMedlineGoogle Scholar8. McFarlaneSmithJohnsonBrayVerganiWilliams IHPGDR. Hepatitis C virus antibodies in chronic active hepatitis: pathogenetic factor or false-positive results? Lancet. 1990:335:754-7. CrossrefMedlineGoogle Scholar9. MarcellinMartinot-PeignouxBoyerPouteauAumontErlinger PMNMPS. Second generation (RIBA) test in diagnosis of chronic hepatitis C [Letter]. Lancet. 1991;337:551-2. CrossrefMedlineGoogle Scholar10. MishiroHoshiTakedaYoshikawaGotandaTakahashi SYKATK. Non-A, non-B hepatitis specific antibodies directed at a host-derived epitope: implication for an autoimmune process. Lancet. 1990:336:1400-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From Hôpital Beaujon, Clichy; and Hôpital Antoine Béclère, Clamart, France. For current author addresses, see end of text. 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Chronic Hepatitis C: Need for Accurate Diagnosis in Selecting PatientsMartin Black, MD, Marion Peters, MDAutoimmune hepatitisAutoimmune hepatitis 1 January 1992Volume 116, Issue 1Page: 51-53KeywordsAlanine aminotransferaseAutoimmune hepatitisChronic hepatitis CFatigueHepatitis C virusInfectious hepatitisLesionsLiver diseasesNauseaViral replication Issue Published: 1 January 1992 PDF downloadLoading ...