tbuckley/cabot-search huggingface dataset:
Cognitive Therapy with Patients with Chronic Physical Illness
Authors: Tom Sensky
Journal: Psychotherapy and Psychosomatics (1989)

Selected cognitive concepts are reviewed which are relevant to the management of emotional disturbance in chronic physical illness. The concepts chosen do not comprise a comprehensive list, but are among those commonly encountered in clinical practice. These are illustrated by brief clinical case descriptions and also discussed in terms of relevant research findings. Particular assets of cognitive therapy are discussed in relation to chronic physical illness.
Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor
Authors: Dietmar M.W. Zaiss, Jorg van Loosdregt, Andrea Gorlani, Cornelis P.J. Bekker, Andrea Gröne, Maria Sibilia, Paul M.P. van Bergen en Henegouwen, Rob C. Roovers, Paul J. Coffer, Alice J.A.M. Sijts
Journal: Immunity (2013)
Molecular characterization of voltage and cyclic nucleotide-gated potassium channels in kidney
Authors: Gary V. Desir
Journal: Kidney International (1995)

Potassium (K + ) channels constitute a diverse group of membrane proteins that facilitate the passive movement (driven by the electrochemical gradient for K + ) of K +  across cell membranes. One or more type of K +  channel can be detected in virtually all mammalian cells. There are extensive data on the kinetic properties and the physiology of K +  channels in kidney. More recently, the initial molecular characterization of some types of renal K channels has been reported. This paper will briefly review the potential physiologic role and the molecular biology of two types of renal K channels, namely those that are regulated by voltage and those that are regulated by cyclic nucleotide.
Managing chronic pain in children and adolescents: Tethered cord syndrome should be considered
Authors: L. G Giles
Journal: BMJ (2003)

EDITOR–Eccleston and Malleson refer to the important and often frustrating topic of managing chronic pain in children and adolescents.1 I reported a case of a 15 year old schoolgirl with chronic increasing pain (for approximately three years) of the thoracolumbar junction that extended bilaterally into …
Successful in vivo blockade of CD25 (high-affinity interleukin 2 receptor) on T cells by administration of humanized anti-Tac antibody to patients with psoriasis
Authors: James G. Krueger, Ian B. Walters, Megumi Miyazawa, Patricia Gilleaudeau, John Hakimi, Susan Light, Amelia Sherr, Alice B. Gottlieb
Journal: Journal of the American Academy of Dermatology (2000)
Histochemistry of the gastric mucosa : 1 In normal mucosa
Authors: J. P. Correia, M. I. Filipe, J. C. Santos
Journal: Gut (1963)

This paper reports a study of the enzyme activity of the gastric mucosa obtained by oral biopsy from normal patients and from those with either gastric or duodenal ulcers or from post-gastrectomy patients. The distribution of enzyme activity between the different cells is described with special reference to the parietal cells.
Factitious Disorders in the Field of Surgery
Authors: Gerhard H. Paar
Journal: Psychotherapy and Psychosomatics (1994)

Review Articles| February 18 2010 Factitious Disorders in the Field of Surgery Subject Area: Psychiatry and Psychology Gerhard H. Paar Gerhard H. Paar Gelderland-Klinik, Geldern, Deutschland Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1994) 62 (1-2): 41–47. https://doi.org/10.1159/000288902 Article history Published Online: February 18 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Gerhard H. Paar; Factitious Disorders in the Field of Surgery. Psychother Psychosom 31 December 1994; 62 (1-2): 41–47. https://doi.org/10.1159/000288902 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1994Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
STUDIES ON THE MOLECULAR WEIGHT OF DIPHTHERIA TOXIN, ANTITOXIN, AND THEIR REACTION PRODUCTS
Authors: A. M. Pappenheimer, H. P. Lundgren, J. W. Williams
Journal: The Journal of Experimental Medicine (1940)

Purified diphtheria antitoxic horse pseudoglobulin has been prepared which is homogeneous by sedimentation, diffusion, and electrophoresis. Immunologically, however, the preparation contains only 43.5 per cent antitoxin specifically precipitable by toxin. The inactive pseudoglobulin remaining after specific precipitation was found to have the same physical and chemical properties as the original antitoxic pseudoglobulin. Although the molecular weight of antitoxin is the same as that of the normal horse serum globulins, the electrophoretic mobility does differ from those normally present. The molecular weight of diphtheria toxin is 70,000 and of antitoxin is 150,000. From ultracentrifuge studies on the two reactants and on mixtures of toxin and antitoxin in the soluble inhibition zones, the average molecular composition of the specific floccules at certain reference points throughout the equivalence zone and the maximum "valence" of toxin and antitoxin with respect to each other have been calculated. The significance of the results has been discussed in relation to antigen-antibody reactions in general and a possible explanation for the exceptional behavior of the toxin-antitoxin reaction in the region of excess antitoxin has been suggested.
Treatment of Pelvic Inflammatory Disease: Use Doxycycline With an Appropriate β-Lactam While We Wait for Better Data
Authors: Pȧl Wølner-Hanssen, David Eschenbach, Jorma Paavonen, King K. Holmes
Journal: JAMA (1986)

Treatment of infertility is glamorous gynecology. Tubal microsurgery, embryo transfer, and in vitro fertilization are available only to women who can afford them. This multimillion-dollar high-technology medical industry is the impressive product of the science and practice of a growing body of specialists—membership in the American Fertility Society has increased from 5746 in 1976 to more than 10 000 in 1986.  Treatment of pelvic inflammatory disease (PID), the most important preventable cause of infertility, afflicting an estimated 1 million American women yearly, is not glamorous gynecology. In this issue ofThe Journal, Grimes et al 1 document the sorry state of affairs for what must be one of the most neglected areas of American medicine. Their analysis of data from a national survey of office-based private physicians shows that from 1966 through 1983, most women with suspected PID were treated on an outpatient basis and most received a single drug.
The Travel Agency Role in Emporiatrics
Authors: Jonathan M. Mann
Journal: JAMA (1984)

<h3>To the Editor.—</h3> Traveler ignorance about health hazards associated with international travel is a major problem.<sup>1-4</sup>At least five readily identifiable groups have a role and a responsibility in protecting the health of Americans who travel abroad: physicians, health departments, travel agencies, commercial carriers, and the travelers themselves.<sup>1,2</sup>However, consultation with physicians or the health department requires an initial level of awareness of potential health problems; many travelers simply may not know enough to ask the proper questions. In contrast, the prospective traveler nearly always encounters the travel agency-commercial carrier network. For this reason, travel agencies are an attractive site for dissemination of health information for international travelers. However, from the travel agency perspective, distribution of health information may be a complex issue, since awareness of health hazards might dissuade some customers from traveling.<sup>1</sup> Our recent experience suggests that despite these potential concerns, travel agencies may be
BLOOD EXAMINATION, FROM THE STANDPOINT OF THE GENERAL PRACTITIONER.
Authors: F. W. HIGGINS
Journal: JAMA (1902)

The relation of the laboratory to the practice of medicine is a topic which has been abundantly discussed in the recent journals. In our modern hospitals the clinical laboratory is considered indispensable; here, urine analysis, blood counts, serum reactions and bacteriological diagnosis are daily occurrences. Our journals are filled with reports of microscopic investigation; many of these articles are preliminary and our memory may leave us doubtful whether further examination has confirmed or denied these bids for precedence.  One of the most enticing of these laboratory studies is the examination of the blood. The beautiful proven results furnished the profession from time to time, and, still more, the brilliant promises of what may be expected in the future make the subject of absorbing interest to the scientific physician of to-day. This holds true, whatever his specialty may be. Many lesions of the eye are found to be explainable only by
Visual Loss in Cytomegalovirus Retinitis Caused by Cystoid Macular Edema in Patients without the Acquired Immune Deficiency Syndrome
Authors: Albert M. Maguire, Charles W. Nichols, Gary W. Crooks
Journal: Ophthalmology (1996)

Although serous macular exudation has been described in patients with the acquired immune deficiency syndrome (AIDS) with active cytomegalovirus (CMV) retinitis, cystoid macular edema (CME) is not encountered in this clinical setting. In contrast to these findings, we describe vision loss due to CME occurring in immunosuppressed patients without AIDS treated for CMV retinitis.Three patients (four eyes) with systemic immunodeficiency presenting with vision loss underwent ophthalmologic examination, including fundus photography and fluorescein angiography. Systemic evaluation was performed to establish the etiology of immunodeficiency and to rule out human immunodeficiency virus infection. Patients were treated with topical corticosteroid and nonsteroidal anti-inflammatory medications for CME.All patients had severe generalized immune deficiency, related either to drug-induced immunosuppression or primary immunodeficiency. Laboratory studies confirmed the presence of systemic CMV infection. Affected eyes had mild reduction of central vision (range, 20/40 to 20/60). Three of four affected eyes had resolving CMV retinitis outside the posterior pole with mild panuveitis. These eyes showed CME on clinical examination and fluorescein angiography. The CMV lesions regressed after reduction of immunosuppressive agents or after systemic antiviral treatment. Response of CME to topical anti-inflammatory medication was variable.Cystoid macular edema can occur in the setting of resolving CMV retinitis in patients with immunodeficiency other than AIDS. This entity is distinct from serous macular exudation, which can occur in patients with AIDS with active CMV retinitis involving the posterior pole. The disparity between patients with and without AIDS in the development of CME may be important in understanding the pathogenesis of CME.
Why Mitochondrial Genes are Most Often Found in Nuclei
Authors: Otto G. Berg, C. G. Kurland
Journal: Molecular Biology and Evolution (2000)

A very small fraction of the proteins required for the propagation and function of mitochondria are coded by their genomes, while nuclear genes code the vast majority. We studied the migration of genes between the two genomes when transfer mechanisms mediate this exchange. We could calculate the influence of differential mutation rates, as well as that of biased transfer rates, on the partitioning of genes between the two genomes. We observe no significant difference in partitioning for haploid and diploid cell populations, but the effective size of cell populations is important. For infinitely large effective populations, higher mutation rates in mitochondria than in nuclear genomes are required to drive mitochondrial genes to the nuclear genome. In the more realistic case of finite populations, gene transfer favoring the nucleus and/or higher mutation rates in the mitochondrion will drive mitochondrial genes to the nucleus. We summarize experimental data that identify a gene transfer process mediated by vacuoles that favors the accumulation of mitochondrial genes in the nuclei of modern cells. Finally, we compare the behavior of mitochondrial genes for which transfer to the nucleus is neutral or influenced by purifying selection.
Perspectives of arterial gene therapy for the prevention of restenosis
Authors: Laurent J. Feldman, Ouafae Tahlil, Gabriel Steg
Journal: Cardiovascular Research (1996)

Restenosis remains the main limitation of interventional cardiology. Restenosis is an important target for gene therapy since it is frequent (30% of patients), costly (estimated $2 billion annually), refractory to all pharmacological therapies, and related, at least in part, to smooth muscle cell proliferation which is an inviting target for antiproliferative molecular strategies. Because cell division is ultimately controlled by intranuclear events, the protein product of genes selected for their antiproliferative effects usually remains inside the cells. Consequently, the transfer of growth-inhibitory genes needs to be efficient—i.e., involve a large proportion of smooth muscle cells populating the angioplasty site. To date, adenoviral vectors are, by far, the most efficient vectors to perform in vivo arterial gene delivery. These vectors, as well as others, have been recently used to demonstrate that therapeutic genes encoding cytolytic (thymidine kinase) or cytostatic (hypophosphorylatable retinoblastoma protein, endothelial nitric oxide synthase, gax, etc.) products successfully inhibit smooth muscle cell proliferation and related intimal hyperplasia. Despite substantial progress, major technical issues remain to be addressed before gene therapy is applied to clinical restenosis. First-generation recombinant adenoviruses evoke both cellular and humoral immune responses leading to local toxicity and transient gene expression. Moreover, the low efficiency of gene transfer to atherosclerotic arteries may further impair the biological effect of antiproliferative genes. Finally, restenosis is a multifactorial phenomenon in which intimal hyperplasia plays an important but not exclusive role. Prevention of constrictive remodeling should also be taken into account in an integrated genetic strategy to prevent restenosis.
Dysregulated expression of androgen-responsive and nonresponsive genes in the androgen-independent prostate cancer xenograft model, CWR22-R
Authors: Lukas Amler, David Agus, Carrie LeDuc, Lisa Sapinoso, William Fox, Suzanne Kern, Dori Lee, Vivian Wang, Mauri Leysens, Brian Higgins, Jason Martin, William Herald, Nicholas Dracopoli, Carlos Cordon-Cardo, Howard Scher, Garret Hampton
Journal: Nature Genetics (2001)
A NOTE ON TREATMENT OF IMPETIGO
Authors: J. L. Newman
Journal: BMJ (1933)

TREATMENT OF IMPETIGO [MTHE BRTTIS 823 found lying one in either iliac fossa near the pelvic brim they were normal in appearance, and showed evidence of the formation of Graafian follicles.There was no trace of a uterus or of any tissue representing it.The technique of the Baldwin operation was followed.A loop of small intestine about 7 inches long and about 12 inches from the ileo-caecal valve was selected.It was isolated, together with its mesen-tery, and the cut ends of the bowel in the loop were permanently closed by purse-string sutures of catgut.The continuity of the intestinal canal was restored by an end-to-end anastomosis.The apex of the U-shaped isolated loop was easily pressed to the bottom of the pelvis, where it was grasped by the forceps previously introduced from the vulva, and drawn to the surface.The isolated loop of bowel was now sutured to the pelvic peritoneum, but this did not exclude it entirely from the peritoneal cavity, as the mesentery passed through the pelvic floor.This con- cluded the intra-abdominal part of the operation, and the abdomen was closed without drainage.The patient was again placed in the lithotomy position.The loop of bowel was of normal colour, and there appeared to be no undue tension on its mesentery.The convexity of the loop was incised and the cut edges sutured to the skin edges within the labia minora.This concluded the operation.The patient made a straight- forward recovery.It was thought advisable to wait a few months before proceeding with the division of the septum between the tubes of the transplanted bowel.At the end of three months the septum had retracted to such an extent that this procedure was unnecessary.At first there was a con- stant discharge of mucus from the vagina, but this rapidly diminished in amount.Two years after the operation the patient was examined.Her general condition, mentally and physically, had im- proved.She expressed herself as well satisfied with the result of the operation, and there is every reason to believe that coitus can be carried out satisfactorily.There is no contraction of the orifice of the vagina, which admits two fingers with ease.A collective review of the literature on the formation of an artificial vagina, by Frank A. Pemberton, is to be found in
Vitamin D nuclear receptor deficiency promotes cholestatic liver injury by disruption of biliary epithelial cell junctions in mice
Authors: Delphine Firrincieli, Silvia Zúñiga, Colette Rey, Dominique Wendum, Elisabeth Lasnier, Dominique Rainteau, Thomas Braescu, Thomas Falguières, Mathieu Boissan, Axelle Cadoret, Chantal Housset, Nicolas Chignard
Journal: Hepatology (2013)

Alterations in apical junctional complexes (AJCs) have been reported in genetic or acquired biliary diseases. The vitamin D nuclear receptor (VDR), predominantly expressed in biliary epithelial cells in the liver, has been shown to regulate AJCs. The aim of our study was thus to investigate the role of VDR in the maintenance of bile duct integrity in mice challenged with biliary-type liver injury. Vdr(-/-) mice subjected to bile duct ligation (BDL) displayed increased liver damage compared to wildtype BDL mice. Adaptation to cholestasis, ascertained by expression of genes involved in bile acid metabolism and tissue repair, was limited in Vdr(-/-) BDL mice. Furthermore, evaluation of Vdr(-/-) BDL mouse liver tissue sections indicated altered E-cadherin staining associated with increased bile duct rupture. Total liver protein analysis revealed that a truncated form of E-cadherin was present in higher amounts in Vdr(-/-) mice subjected to BDL compared to wildtype BDL mice. Truncated E-cadherin was also associated with loss of cell adhesion in biliary epithelial cells silenced for VDR. In these cells, E-cadherin cleavage occurred together with calpain 1 activation and was prevented by the silencing of calpain 1. Furthermore, VDR deficiency led to the activation of the epidermal growth factor receptor (EGFR) pathway, while EGFR activation by EGF induced both calpain 1 activation and E-cadherin cleavage in these cells. Finally, truncation of E-cadherin was blunted when EGFR signaling was inhibited in VDR-silenced cells. Biliary-type liver injury is exacerbated in Vdr(-/-) mice by limited adaptive response and increased bile duct rupture. These results indicate that loss of VDR restricts the adaptation to cholestasis and diminishes bile duct integrity in the setting of biliary-type liver injury.
Measuring Quality of Life Near the End of Life
Authors: Nancy R. Zweibel
Journal: JAMA (1988)

Danis and colleagues<sup>1</sup>have chosen to examine an important question in medical ethics—to what extent should quality-of-life judgments be applied in decision making for incompetent patients when no advance directives exist? Few studies in this field have attempted to empirically assess the validity of decision making for incompetent patients. Fewer still have examined "informed treatment preferences" by asking patients who have already experienced a particular intervention to project what they think their future treatment preferences for this intervention might be. For these reasons, the study by Danis et al is a noteworthy contribution to the literature. One question that can be raised about this research, however, concerns the way in which its authors measured quality of life and the implications of this measurement strategy for interpretation of the findings related to this variable. The authors obtained data on willingness to repeat intensive care and on perceived quality of life (among
A Critical Role for Stat3 Signaling in Immune Tolerance
Authors: Fengdong Cheng, Hong-Wei Wang, Alex Cuenca, Mei Huang, Tomar Ghansah, Jason Brayer, William G. Kerr, Kiyoshi Takeda, Shizuo Akira, Stephen P. Schoenberger, Hua Yu, Richard Jove, Eduardo M. Sotomayor
Journal: Immunity (2003)