Isoniazid-Induced Acute Pancreatitis
Authors: Alfredo A. Rabassa
Journal: Annals of Internal Medicine (1994)

Brief Communications15 September 1994Isoniazid-Induced Acute PancreatitisAlfredo A. Rabassa, MD, Gary Trey, MD, Urmil Shukla, MD, Tobias Samo, MD, and Bhupinderjit S. Anand, MDAlfredo A. Rabassa, MDFrom Baylor College of Medicine, Houston, Texas., Gary Trey, MDFrom Baylor College of Medicine, Houston, Texas., Urmil Shukla, MDFrom Baylor College of Medicine, Houston, Texas., Tobias Samo, MDFrom Baylor College of Medicine, Houston, Texas., and Bhupinderjit S. Anand, MDFrom Baylor College of Medicine, Houston, Texas.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-6-199409150-00007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In recent years, a resurgence of Mycobacterium tuberculosis has occurred in the United States [1], resulting in a marked increase in the use of antituberculous drugs. Isoniazid is a first-line drug in the treatment of tuberculosis and is increasingly being used as a chemoprophylactic agent. Severe adverse reactions with isoniazid have been observed; these include hepatitis, peripheral neuropathy, skin rashes, neurologic disturbances, and hematologic alterations [2, 3]. We describe a patient with the first well-documented case of isoniazid-induced acute pancreatitis.Case ReportA 31-year-old man from India presented to the emergency department with complaints of several days of weakness, fever, ...References1. Barnes PF, Barrows SA. Tuberculosis in the 1990s. Ann Intern Med. 1993; 119:400-10. Google Scholar2. Davidson PT, Le HQ. Drug treatment of tuberculosis-1992. Drugs. 1992; 43:651-73. Google Scholar3. Goldman AL, Braman SS. Isoniazid: a review with emphasis on adverse effects. Chest. 1972; 62:71-7. Google Scholar4. Center for Disease Control. Tuberculosis and human immunodeficiency virus infection: recommendations of the Advisory Committee for the Elimination of Tuberculosis (ACET). MMWR Morb Mortal Wkly Rep. 1989; 38:236-8. Google Scholar5. Pape JW, Jean SS, Ho JL, Hafner A, Johnson WD Jr. Effect of isoniazid prophylaxis on incidence of active tuberculosis and progression of HIV infection. Lancet. 1993; 342:268-72. Google Scholar6. Mattson K. Side effects of rifampicin. A clinical study. Scand J Respir Dis. 1973; 82(Suppl):1-52. Google Scholar7. Guerra M. Toxicity of indomethacin. Report of a case of acute pancreatitis. JAMA. 1967; 200:552-3. Google Scholar8. Larsen RR, Sawyer RB, Sawyer CK, McCurdy RE. Hemorrhagic pancreatitis complicating anticoagulant therapy. NY J Med. 1962; 62:2397-9. Google Scholar9. Kvale PA, Parks RD. Acute abdomen. An unusual reaction to isoniazid (Letter). Chest. 1975; 68:271-2. Google Scholar10. Bonacini M. Pancreatic involvement in human immunodeficiency virus infection. J Clin Gastroenterol. 1991; 13:58-64. Google Scholar Author, Article, and Disclosure InformationAffiliations: From Baylor College of Medicine, Houston, Texas.Corresponding Author: Bhupinderjit S. Anand, MD, Gastroenterology Section, Smith Tower, 6550 Fannin, SM 1122, Houston, TX 77030. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrugs associated with drug-induced pancreatitis: focus on rarely discussed drugsDrug induced pancreatitis: A systematic review of case reports to determine potential drug associationsIsoniazid and Related HydrazinesIsoniazid and Related HydrazinesIsoniazidIsoniazid-Induced Acute Pancreatitis with PseudocystIsoniazidANTIBACTERIAL DRUGSDrug-Induced PancreatitisLiver and Pancreatic Injury Induced by Antituberculous TherapyDrug-Induced Acute Pancreatitis: An Evidence-Based ReviewPancreatitis aguda inducida por isoniazidaIsoniazidIsoniazidIsoniazid-Induced Acute Hepatitis and Acute Pancreatitis in a Patient During ChemoprophylaxisAcute pancreatitis induced by isoniazidAcute and chronic pancreatitisAcute pancreatitis induced by isoniazid in the treatment of tuberculosisManagement of PancreatitisAcute pancreatitis in human immunodeficiency virus–infected patients: a reviewPancreatic Insufficiency Due to Antituberculous TherapyReview article: Drug-induced pancreatitis 15 September 1994Volume 121, Issue 6Page: 433-434KeywordsAcute pancreatitisDrugsFeversIsoniazidLaboratory testsLipasesPancreatitisTuberculosis drug discoveryUlcersVomiting Issue Published: 15 September 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...