tbuckley/cabot-search huggingface dataset:
Tetracycline-Resistant Ureaplasma urealyticum: A Cause of Persistent Nongonococcal Urethritis
Authors: John B. Stimson, Judith Hale, William R. Bowie, King K. Holmes
Journal: Annals of Internal Medicine (1981)

We treated 289 men with nongonococcal urethritis in a randomized, double-blind study with minocycline, 100 mg once or twice daily for 7 or 21 days. Ureaplasma urealyticum was isolated before treatment from 167 (58%). The pretherapy isolates from 82 men re-examined 6 to 8 days after initiation of treatment were viable. In six (7%) isolates were resistant to 256 µg/mL or more of tetracycline. Tetracycline resistance was significantly correlated with persistence of U. urealyticum and persistence of nongonococcal urethritis during treatment. Recurrence of nongonococcal urethritis after initial resolution and recurrence of U. urealyticum after interim negative cultures were not correlated with tetracycline resistance of U. urealyticum. Thus tetracycline-resistant strains of U. urealyticum are a cause of persistent but not of recurrent nongonococcal urethritis.
Summary of Necropsy
Authors: D. S. Russell
Journal: BMJ (1931)

respirations 30.On November 23rd there was dullness over the left lower lobe, with rales over the right side.The sputum was scanty and rusty.She complained a good deal of frontal headache, and had difficulty in swallowing.After November 24th she begail to have incontinence of urine and faeces, which continued until herdeath.On November 26th there appeared to be paralysis of the left side of the body and the right side of the face, but this passed off in a couple of days.Gradually, however, nervous symptoms became more marked, together with abdominal tumescence, drowsiness, and symptoms generally reminiscent of typhoid fever.In fact, during the last five days of her life, the patient was in a typhoid state, more or less unconscious, and with a subnormial temperature.She died on the morning of December 3rd.Two other nurses in attendance on the first two cases remained well, and there were no other cases in the home of the original patients. SUMMARYThe sequence of events in these cases was as follows: 1.At the end of September or the beginning of October, 1930, patient No. 1 nursed a sick budgerigar.2. October 11th, patient No. 1 fell ill when away from home on a visit.She eventually recovered, but as late as January 15th, 1931, was reported still to be suffering from insomnia, lack of energy, and occasional depression.3. October 26th, patient No. 2 fell ill.She had nursed patient No. 1, had shared her bed, and was probably infected by her. 4. November 8th, patient.No. 2 died. 5. November 19th, patient No. 3 fell ill.She was a hospital nurse in attendance on the previous patients from October 23rd, and was infected by them.6. December 3rd, patient No. 3 died.The source of inifection of the budgerigar was not definitely traced.A number of other birds, budgerigars, foreign finches, and a blue and white canary, had died in the aviary from an unknown cause during September and the beginning of October, and the dealer who had supplied the birds admitted to deaths among the birds in his shop.Later on this dealer was found to have been importing budgerigars from the Continent, but he maintained that the birds he had sold to these ladies were home-bred.
A multiparametric approach is essential to define different clinicopathological entities within pseudopelade of Brocq
Authors: L. Amato, D. Massi, S. Berti, S. Moretti, P. Fabbri
Journal: British Journal of Dermatology (2002)

Journal Article A multiparametric approach is essential to define different clinicopathological entities within pseudopelade of Brocq Get access L. Amato, L. Amato Second Dermatology Clinic Department of Dermatological Sciences, Department of Human Pathology and Oncology, Università degli Studi di Firenze, Via della Pergola, 58 50121 Florence, Italy E‐mail: fabbri@unifi.it Search for other works by this author on: Oxford Academic Google Scholar D. Massi, D. Massi Second Dermatology Clinic Department of Dermatological Sciences, Department of Human Pathology and Oncology, Università degli Studi di Firenze, Via della Pergola, 58 50121 Florence, Italy E‐mail: fabbri@unifi.it Search for other works by this author on: Oxford Academic Google Scholar S. Berti, S. Berti Second Dermatology Clinic Department of Dermatological Sciences, Department of Human Pathology and Oncology, Università degli Studi di Firenze, Via della Pergola, 58 50121 Florence, Italy E‐mail: fabbri@unifi.it Search for other works by this author on: Oxford Academic Google Scholar S. Moretti, S. Moretti Second Dermatology Clinic Department of Dermatological Sciences, Department of Human Pathology and Oncology, Università degli Studi di Firenze, Via della Pergola, 58 50121 Florence, Italy E‐mail: fabbri@unifi.it Search for other works by this author on: Oxford Academic Google Scholar P. Fabbri P. Fabbri Second Dermatology Clinic Department of Dermatological Sciences, Department of Human Pathology and Oncology, Università degli Studi di Firenze, Via della Pergola, 58 50121 Florence, Italy E‐mail: fabbri@unifi.it Prof. Paolo Fabbri fabbri@unifi.it Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 146, Issue 3, 1 March 2002, Page 532, https://doi.org/10.1046/j.1365-2133.2002.46527.x Published: 01 March 2002
Detection of BCR/ABL gene rearrangement and the elimination of rearranged clone in chronic myelocytic leukemia patients
Authors: E. Eren, U. Aytac, E. Tetik, O. Akman, E. Kansu, U. Gunduz
Journal: American Journal of Hematology (2000)

Cytogenetic and molecular studies were performed on 20 interferon-α receiving Turkish chronic myelocytic leukemia patients. Four different restriction endonucleases and bcr-G probe were used for southern blot analysis to detect rearrangements of the bcr gene. The RT-PCR method was also applied to detect chimeric bcr/abl mRNA. Seventeen patients showed a chromosomal break within the 5.8 kb M-bcr region by southern blot analysis while three cases out of 20 have not shown any rearrangement. These three cases were further analysed by RT-PCR and they were also found to be carrying the Philadelphia translocation (Ph). However, in four years of follow-up this RT-PCR positivity has disappeared, which suggests an elimination of Ph clone with prolonged interferon-α treatment. Am. J. Hematol. 63:85–89, 2000. © 2000 Wiley-Liss, Inc.
Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells
Authors: Chen-Hsin Liao, Chau-Ting Yeh, Ya-Hui Huang, Sheng-Ming Wu, Hsiang-Cheng Chi, Ming-Ming Tsai, Chung-Ying Tsai, Chia-Jung Liao, Yi-Hsin Tseng, Yang-Hsiang Lin, Cheng-Yi Chen, I-Hsiao Chung, Wan-Li Cheng, Wei-Jan Chen, Kwang-Huei Lin
Journal: Hepatology (2011)

Thyroid hormone (T(3)) mediates cellular growth, development, and differentiation by binding to the nuclear thyroid hormone receptor (TR). Recent studies suggest that long-term hypothyroidism is associated with human hepatocellular carcinoma (HCC) independent from other major HCC risk factors. Dickkopf (DKK) 4, a secreted protein, antagonizes the Wnt signal pathway. In this study, we demonstrate that T(3) may play a suppressor role by inducing DKK4 expression in HCC cells at both the messenger RNA (mRNA) and protein levels. DKK4 was down-regulated in 67.5% of HCC cancerous tissues. The decrease in DKK4 levels was accompanied by a concomitant decrease in TR protein levels in the matched cancerous tissues in 31% of tissues compared by immunoblotting with the adjacent noncancerous tissues. Further, TR and DKK4 expression levels were positively correlated in both normal and cancerous specimens by tissue array analysis. In function assays, stable DKK4 transfected into J7 or HepG2 cells decreased cell invasion in vitro. Conversely, knocking down DKK4 restores cell invasiveness. DKK4-expressing J7 clones showed increased degradation of β-catenin, but down-regulation of CD44, cyclin D1, and c-Jun. To investigate the effect of DKK4 and TR on tumor growth in vivo, we established a xenograft of J7 cells in nude mice. J7-DKK4 and J7-TRα1 overexpressing mice, which displayed growth arrest, lower lung colony formation index, and smaller tumor size than in control mice, supporting an inhibitory role of DKK4 in tumor progression.Taken together, these data suggest that the TR/DKK4/Wnt/β-catenin cascade influences the proliferation and migration of hepatoma cells during the metastasis process and support a tumor suppressor role of the TR.
MAI Osteomyelitis 18-Year Scintigraphic Follow-Up
Authors: SEAN MAHAN, PAUL R. JOLLES
Journal: Clinical Nuclear Medicine (1995)

Mycobacterium avium-intracellulare osteomyelitis is an infrequently reported entity, especially in immunocompetent patients. When multifocal, the imaging findings can be confusing, simulating metastatic disease or other bone lesions. An immunocompetent patient with multifocal Mycobacterium avium-intracellulare osteomyelitis is presented who has been followed for 18 years and experienced episodes of exacerbations and further dissemination of her disease, followed by periods of partial remission and clinical quiescence. Bone scintigraphy was very useful in evaluating the extent of involvement and monitoring response to treatment.
Calcification of the transverse ligament of the atlas in chondrocalcinosis: computed tomography study.
Authors: A Constantin, F Marin, E Bon, M Fedele, B Lagarrigue, G Bouteiller
Journal: Annals of the Rheumatic Diseases (1996)

To seek an association between articular chondrocalcinosis (AC) and calcification of the transverse ligament of the atlas (TLA), and to evaluate the frequency and the main computed tomography appearances of such calcification.Axial computed tomography slices of the cervico-occipital hinge were performed routinely in 21 patients with AC (three men, 18 women; mean age 79 years, range 67-87) and compared with those from a control group of 21 age and gender matched patients without AC.Calcification of the TLA was present in 14 of the 21 patients (66%) in the AC group and in none of the 21 patients (0%) in the control group (chi 2 test: p < 0.001). Calcification was localised behind the odontoid process, inserted upon the osseous tubercles of the lateral masses of C1, and had a curvilinear profile; it varied in height (1.5 to 9 mm) and appearance (thin = < 1 mm; thick = > 1 mm) and formed either a single or a double band.This study has demonstrated a relationship between AC and calcification of the TLA. Although such calcification often remains asymptomatic (nine of 14 patients in our study), it may be associated with attacks of acute neck pain with segmentary stiffness, fever, and an increased erythrocyte sedimentation rate, sometimes revealing AC.
REDUCTION IN FIRST AND RECURRENT CARDIOVASCULAR AND ISCHEMIC EVENTS WITH TICAGRELOR COMPARED WITH CLOPIDOGREL IN THE PLATO STUDY
Authors: Payal Kohli, Lars Wallentin, Eric Reyes, Jay Horrow, Steen Husted, Robert Storey, Stefan James, Christopher Cannon
Journal: Journal of the American College of Cardiology (2012)
REMARKS on the DOSAGE of CHLOROFORM: Being the Substance of a Communication to the Society of Anaesthetists
Authors: A. D. Waller
Journal: BMJ (1898)

JOURNAL for November 20th, I897.But whereas on that occasion I very deliberately laid principal stress upon the great power of chloroform and upon the absolute cer- tainty of a considerable--percentage of avoidable-and there- fore unjustifiable deaths if chloroform is administered with- out adequate recognition of this fact-and by adequate recognition I mean recognition in numerical values-on the present occasion, in presence of an expert audience, I am about to urge the importance of a complementary principle in the practice of aniesthesia by chloroform-namely, upon the paramount-necessity for dosage in its administration.Many practical ansesthetists, I know, admit this principle; others, I believe, do not, or at least hold it to be, if theoretically desirable, practically Impossible.My argument to-day is that the evidetice in point shows that it is necessary and within reasonable limits of error practicable, and I should like at once to characterise and earmark that argument by the statement that successful chloroform aniesthesia requires the regular respiration of air in which the chloroform vapour is maintained between the limits of I and 2 per ioo.This conclusion, the arithmetical data of which I am about to submit to you, is indeed the' second and -final step in an argument to which I have been impelled, primarily by laboratory 'measurements, secondarily by the published records of ansesthetists, among whom I may name as having most influenced my mind, Snow, Clover, Bert, and Dubois.Before actually embarking on details bearing upon the question of chloroform dosage, allow me to say that that question was fully present to my mind at Montreal when T formulated the two a ternatives of the " chloroform dilemma,"and seemed thereby to the heedless reader to be proscribing its right and proper administration.Lest now, in addressing myself to the dosage of cbloroform, I should give rise to an opposite misreading, and be hastily put down as pleading for chloroform, let me reaffirm'and further define the issue under consideration, which is the natural conclusion of my argument at Montreal, and the natural commencement of my argument here.The dangers of chloroform are universally admitted.Whether chiloroform be (i) dangerous under all circum- stances, or (2) dangerous only when carelessly or unskilfully administered, death by chloroform employed for purposes of minor surgery is primd facie an unjustifiable event, which should be subject to judicial investigation.TH9'"'DOSA44E '' O'F' 0,HLOROFORM.A-p-ni ^23,-189&]
Common Cholesteryl Ester Transfer Protein Gene Polymorphisms and the Effect of Atorvastatin Therapy in Type 2 Diabetes
Authors: Francine V. van Venrooij, Ronald P. Stolk, Jan-Dirk Banga, Tjeerd P. Sijmonsma, Arie van Tol, D. Willem Erkelens, Geesje M. Dallinga-Thie
Journal: Diabetes Care (2003)

OBJECTIVE—The cholesteryl ester transfer protein (CETP) plays a key role in the remodeling of triglyceride (TG)-rich and HDL particles. Sequence variations in the CETP gene may interfere with the effect of lipid-lowering treatment in type 2 diabetes. RESEARCH DESIGN AND METHODS—We performed a 30-week randomized double-blind placebo-controlled trial with atorvastatin 10 mg (A10) and 80 mg (A80) in 217 unrelated patients with diabetes. RESULTS—CETP TaqIB and A-629C polymorphisms were tightly concordant (P &amp;lt; 0.001). At baseline, B1B1 carriers had lower plasma HDL cholesterol (0.99 ± 0.2 vs. 1.11 ± 0.2 mmol/l, P &amp;lt; 0.05), higher CETP mass (2.62 ± 0.8 vs. 2.05 ± 0.4 mg/l, P &amp;lt; 0.001), and slightly increased, though not significant, plasma TGs (2.7 ± 1.05 vs. 2.47 ± 0.86, P = 0.34) compared with B2B2 carriers. Atorvastatin treatment significantly reduced CETP mass dose-dependently by 18% (A10) and 29% (A80; both vs. placebo P &amp;lt; 0.001, A10-A80 P &amp;lt; 0.001). CETP mass and activity were strongly correlated (r = 0.854, P &amp;lt; 0.0001). CETP TaqIB polymorphism appeared to modify the effect of atorvastatin on HDL cholesterol elevation (B1B1 7.2%, B1B2 6.1%, B2B2 0.5%; P &amp;lt; 0.05), TG reduction (B1B1 39.7%, B1B2 38.4%, B2B2 18.4%; P = 0.08), and CETP mass reduction (B1B1 32.1%, B1B2 29.6%, B2B2 21.9%; P = 0.27, NS). Similar results were obtained for the A-629C polymorphism. CONCLUSIONS—In conclusion, the B1B1/CC carriers of the CETP polymorphisms have a more atherogenic lipid profile, including low HDL, and they respond better to statin therapy. These results favor the hypothesis that CETP polymorphisms modify the effect of statin treatment and may help to identify patients who will benefit most from statin therapy.
Botulinum Toxin Reduces Dysphagia in Patients With Nonachalasia Primary Esophageal Motility Disorders
Authors: Tim Vanuytsel, Raf Bisschops, Ricard Farré, Ans Pauwels, Lieselot Holvoet, Joris Arts, Philip Caenepeel, Dominiek De Wulf, Kostas Mimidis, Nathalie Rommel, Jan Tack
Journal: Clinical Gastroenterology and Hepatology (2013)
Relation between surgeon volume and risk of complications after total hip arthroplasty: propensity score matched cohort study
Authors: B. Ravi, R. Jenkinson, P. C. Austin, R. Croxford, D. Wasserstein, B. Escott, J. M. Paterson, H. Kreder, G. A. Hawker
Journal: BMJ (2014)

<b>Objectives</b> To identify a cut point in annual surgeon volume associated with increased risk of complications after primary elective total hip arthroplasty and to quantify any risk identified. <b>Design</b> Propensity score matched cohort study. <b>Setting</b> Ontario, Canada <b>Participants</b> 37 881 people who received their first primary total hip arthroplasty during 2002-09 and were followed for at least two years after their surgery. <b>Main outcome measure</b> The rates of various surgical complications within 90 days (venous thromboembolism, death) and within two years (infection, dislocation, periprosthetic fracture, revision) of surgery. <b>Results</b> Multivariate splines were developed to visualize the relation between surgeon volume and the risk for various complications. A threshold of 35 cases a year was identified, under which there was an increased risk of dislocation and revision. 6716 patients whose total hip arthroplasty was carried out by surgeons who had done ≤35 such procedure in the previous year were successfully matched to patients whose surgeon had carried out more than 35 procedures. Patients in the former group had higher rates of dislocation (1.9% <i>v</i> 1.3%, P=0.006; NNH 172) and revision (1.5% <i>v</i> 1.0%, P=0.03; NNH 204). <b>Conclusions</b> In a cohort of first time recipients of total hip arthroplasty, patients whose operation was carried by surgeons who had performed 35 or fewer such procedures in the year before the index procedure were at increased risk for dislocation and early revision. Surgeons should consider performing 35 cases or more a year to minimize the risk for complications. Furthermore, the methods used to visualize the relationship between surgeon volume and the occurrence of complications can be easily applied in any jurisdiction, to help inform and optimize local healthcare delivery.
Is the FDA approving drugs too fast?
Authors: J D Kleinke, S. Gottlieb
Journal: BMJ (1998)

Debate in the United States about the optimal amount of time required by the Food and Drug Administration for adequate testing of new drugs has raged since 1962, when Congress established formal criteria for proving drug safety and effectiveness. Through much of the past decade the FDA has been accused of delaying drug approvals: now it is accused of acting too hastily in approving drugs that have later had to be withdrawn.

The height of the initial criticism came in 1995, with the election of a Republican majority in Congress that favoured full privatisation of all healthcare matters. The Republican speaker of the House of Representatives, Newt Gingrich, referred to the FDA as “job killers”: its excessive reviews, he claimed, delayed the launch of new drugs and thereby forestalled growth for the pharmaceutical industry.1

Although the agency disputed that its reviews were excessive, the FDA had already argued that the increase in the number of drugs seeking approval had stretched the agency beyond its means and was indeed …
Bone Metastases Mimicking Sickle Cell Crisis
Authors: Mason G. Robertson
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Sickle cell crises associated with sickle cell thalassemia and other combined hemoglobinopathies are common in a black population. The problem of distinguishing pain of the bone due to thrombotic crises from other causes of pain in the bone can be difficult. <h3>Report of a Case.—</h3> A 31-year-old rather husky short-statured black American dock worker was hospitalized at Memorial Medical Center in Savannah with severe pains in his legs. Several months previously, he had been hospitalized in the same institution for idiopathic hematuria. Hematological workup, including starch gel hemoglobin electrophoresis had revealed hemoglobin-S thalassemia with a hemoglobin A<sub>2</sub>value of 5.0%. The hematogram revealed a hemoglobin value of 15 gm/ 100 ml, and a normal white blood cell count, differential cell count, and platelet count, but a sickle cell preparation had been positive. He had given no previous history of pains in the bone or crises. On
Rubella Immunization: A Five-Year Progress Report
Authors: Saul Krugman, Samuel L. Katz
Journal: New England Journal of Medicine (1974)

This month, June, 1974, is the 10th anniversary of one of the most extensive rubella epidemics ever recorded in the United States. The subsequent toll was measured in terms of personal tragedy for many thousands of families who have had to care for their multi-handicapped children. More than 20,000 infants were born with one or more of the following manifestations of congenital rubella: eye lesions such as cataract and glaucoma; deafness; cardiac malformations; and Central-nervous-system involvement leading to severe behavior disorders, cerebral palsy and mental retardation.This month is also the fifth anniversary of the licensure of live, attenuated rubella-virus . . .
Abstract 5319: The role of Notch and Delta-like 1 in antitumor immunity
Authors: Mikhail M. Dikov, Yuhui Huang, Li Yang, Lupin Lin, David P. Carbone
Journal: Cancer Research (2010)

Abstract Defects in T cell function are evident in tumor bearing hosts. One potential mechanism for these hematopoietic defects is disruption of Notch signaling which is essential for T- versus B-lineage commitment, and it is clear that Delta-like 1 (DLL1) and Delta-like 4 (DLL4) are critical in this process 1-4. Here we show that tumor-associated defects in T cell development are characterized by attenuated levels of DLL1 and DLL4 in the bone marrow (BM) microenvironment, and elevated circulating vascular endothelial growth factor (VEGF) is one causative factor. We also show that elective therapeutic stimulation of Notch signaling in animals using multivalent form of DLL1 significantly reduces tumor growth, rescues T cell development and enhances T cell-mediated immune responses and that over-expression of DLL1 alone in BM precursors also inhibits tumor growth and improves anti-tumor immunity. Thus, stimulation of DLL1-Notch signaling represents a new strategy to overcome tumor immune dysfunction. As neutralizing DLL4 has been proposed as an approach to inhibit tumor growth by regulating tumor angiogenesis, our data suggest that combining stimulation or blockade of specific context-dependent Notch signaling may optimally inhibit tumor growth via multiple distinct mechanisms. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5319.