Conservative Anticoagulant Therapy of Acute Myocardial Infarction
Authors: GEORGE C. GRIFFITH
Journal: Annals of Internal Medicine (1962)

Article1 August 1962Conservative Anticoagulant Therapy of Acute Myocardial InfarctionGEORGE C. GRIFFITH, M.D., F.A.C.P., DAVID LEAK, M.B., M.R.C.P. (EDIN.), BALAKRISHNA HEGDE, G.C.I.M., M.S. (MED.)GEORGE C. GRIFFITH, M.D., F.A.C.P., DAVID LEAK, M.B., M.R.C.P. (EDIN.), BALAKRISHNA HEGDE, G.C.I.M., M.S. (MED.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-2-254 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough the value of anticoagulants in the short-term treatment of acute myocardial infarction is still not settled, the majority of authors working in many different parts of the world have repeatedly claimed that anticoagulants reduce the mortality rate by one-half to one-third (1, 2). In the case of such apparent unanimity, it may seem difficult to justify still another examination of this problem, yet we feel that there are a number of points worthy of further study.Firstly, the belief that there is an optimal level of anticoagulant therapy which produces a depression of the prothrombin level within a so-called...References1. WRIGHT IS: Early use of anticoagulants in the treatment of myocardial infarction. J. A. M. A. 163: 918, 1957. CrossrefMedlineGoogle Scholar2. GILCHRIST AR: Anticoagulant therapy, in Pathogenesis and Treatment of Occlusive Arterial Disease, ed. by McDonald, L., Pitman Medical Publishing Company, Ltd., London, 1960, p. 163. Google Scholar3. ALEXANDERWESSLER BS: Anticoagulant control. Circulation 24: 122, 1961. Google Scholar4. LEMPERTPOLLER HL: Evaluation of thrombotest on the control of anticoagulant therapy. Lancet 2: 1115, 1960. CrossrefMedlineGoogle Scholar5. SMITHSCHELLING FJV: A clinical comparison of laboratory methods used in controlling oral anticoagulant therapy, in Proceedings of the First International Conference on Thrombosis and Embolism, ed. by Koller, T., and Merz, W. R., Benno Schwabe & Company, Basel, 1955, p. 815. Google Scholar6. WAALER BA: The effect of permanent anticoagulant therapy on symptoms and mortality in angina pectoris. Acta Med. Scand. 157: 289, 1957. CrossrefMedlineGoogle Scholar7. CONRADROTHERMICH FGNO: A clinicopathological study of acute myocardial infarction and the role of anticoagulation therapy. Arch. Intern. Med. 103: 421, 1959. CrossrefGoogle Scholar8. BORCHGREVNIK CF: Long term anticoagulant therapy in angina pectoris and myocardial infarction. Acta Med. Scand. 168: supp. 359, 1960. Google Scholar9. BJERKELUND CJ: The effect of long term anticoagulant treatment with Dicoumarol in myocardial infarction. Acta Med. Scand. 158: supp. 330, 1957. Google Scholar10. HILL IG: The management of coronary heart disease, in Modern Trends in Cardiology, ed. by Jones, A. M., Butterworth & Company, Ltd., London, 1960, p. 241. Google Scholar11. MCMICHAELPARRY JEH: Prognosis and anticoagulant prophylaxis after coronary occlusion. Lancet 2: 991, 1960. CrossrefMedlineGoogle Scholar12. RUSSEKZOHMAN HIBL: Chances for survival in acute myocardial infarction. J. A. M. A. 156: 765, 1954. CrossrefMedlineGoogle Scholar13. HONEYTRUELOVE GESC: Prognostic factors in myocardial infarction. Lancet 1: 1155, 1957. CrossrefGoogle Scholar14. HALPERNLEMBERGBELLEEICHERT MMLMH: The selective use of anticoagulants in acute myocardial infarction based on initial prognosis. Ann. Intern. Med. 41: 942, 1954. LinkGoogle Scholar15. WRIGHT IS: Treatment of thromboembolic disease. Criteria for evaluation of studies J. A. M. A. 174: 1921, 1960. CrossrefMedlineGoogle Scholar16. FRIEDBERG CK: A critical appraisal of anticoagulants for short-term and long-term use in the management of myocardial infarction and systemic arterial embolism. New York J. Med. 58: 877, 1958. MedlineGoogle Scholar17. WARESTRAGNELL AGR: An improved onestage prothrombin method. Amer. J. Clin. Path. 22: 791, 1952. CrossrefMedlineGoogle Scholar18. RAPAPORT SI: Personal communication. Google Scholar19. WRIGHT IS: The use of anticoagulants in coronary heart disease. Circulation 22: 608, 1960. CrossrefMedlineGoogle Scholar20. BLOCKCRUMPACKERDRY WJELTJ: Prognosis of angina pectoris. Observations in 6,882 cases. J. A. M. A. 150: 259, 1952. CrossrefMedlineGoogle Scholar21. SMITHRODMANPASTOR RTBH: A comparative study of prothrombinopenic anticoagulant drugs. J. A. M. A. 174: 1917, 1960. CrossrefGoogle Scholar22. MCCLUSKIESEATON JADA: The value of anticoagulant therapy in the treatment of acute myocardial infarction. Scot. Med. J. 4: 305, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, CaliforniaFrom the University of Southern California School of Medicine and the Los Angeles County Hospital, Los Angeles, California.Requests for reprints should be addressed to George C. Griffith, M.D., Department of Medicine, Cardiology, Box 25, 1200 North State Street, Los Angeles 33, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMedical Treatment of Stable AnginaEvidence Favoring the Use of Anticoagulants in the Hospital Phase of Acute Myocardial InfarctionReduction of Hospital Mortality from Acute Myocardial Infarction by Anticoagulant TherapyRetrospective Evidence Favoring Use of Anticoagulants for Myocardial InfarctionsAnticoagulation Therapy in Myocardial InfarctionAnticoagulant therapy and rectus sheath hematomaA Critique of Methodology in Studies of Anticoagulant Therapy for Acute Myocardial InfarctionANTICOAGULANT TREATMENT OF ACUTE CORONARY THROMBOSISManagement of arrhythmias in acute myocardial infarctionNatural history and clinical significance of arrhythmias after acute cardiac infarction.Hematoma of the rectus abdominis muscle complicated by anticoagulation therapyTreatment of acute myocardial infarction with propranololChoice of Drugs in Angina PectorisHow Effective Is Clinical Control of Anticoagulant Therapy?Disturbances of rate, rhythm and conduction in acute myocardial infarctionThe Case for Anticoagulant TherapyArrhythmias in Acute Myocardial InfarctionA Double Blind Study of Dicumarol Prophylaxis in Coronary Heart DiseaseAnticoagulant Therapy TodayCORONARY UNIT AN INTENSIVE-CARE CENTRE FOR ACUTE MYOCARDIAL INFARCTIONA Modern PlagueAnticoagulant Treatment for Coronary ThrombosisURÆMIA IN ACUTE RENAL FAILUREEVALUATION OF ANTICOAGULANT THERAPY FOR MYOCARDIAL INFARCTIONTHE "PROTEIN INTERFERENCE EFFECT" IN THE ROUTINE DETERMINATION OF SERUM AND PLASMA SODIUM LEVELS BY FLAME PHOTOMETRYSUCTION DRAINAGE OF WOUNDSEVALUATION OF ANTICOAGULANT THERAPY FOR MYOCARDIAL INFARCTIONSome Considerations regarding the Value of Anticoagulants in Acute Myocardial InfarctionANTICOAGULANT TREATMENTEVALUATION OF ANTICOAGULANT THERAPY FOR MYOCARDIAL INFARCTION 1 August 1962Volume 57, Issue 2_Part_1Page: 254-265KeywordsAcute myocardial infarctionAnticoagulant therapyAnticoagulantsDeath ratesHospital medicine Issue Published: 1 August 1962 PDF DownloadLoading ...