tbuckley/cabot-search huggingface dataset:
Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fibrosis
Authors: J C Ojoo
Journal: Thorax (2004)

<b>Background:</b> It has been proposed that the pH of airway lining fluid may regulate the fractional exhaled concentration of nitric oxide (Fe<sub>NO</sub>) in respiratory disease. <b>Methods:</b> Fe<sub>NO</sub>, exhaled breath condensate (EBC) pH, and EBC concentrations of nitrite plus nitrate (NO<sub>2</sub>/NO<sub>3</sub>) were compared in 12 subjects with stable asthma, 18 with stable cystic fibrosis (CF), and 15 healthy control subjects. Eight of the CF patients were studied on a separate occasion at the start of a pulmonary exacerbation. <b>Results:</b> Fe<sub>NO</sub> was significantly greater in asthmatic subjects than in control subjects (mean 35 <i>v</i> 9 ppb, p&lt;0.001). EBC pH, however, was similar in the asthmatic and control groups (median 5.82 <i>v</i> 6.08, p = 0.23). Levels of NO<sub>2</sub>/NO<sub>3</sub> were on average higher in EBC samples from asthmatic subjects, but the difference was not significant. In patients with stable CF both the Fe<sub>NO</sub> (mean 4 ppb, p&lt;0.001) and EBC pH (median 5.77, p = 0.003) were lower than in the control group. Levels of EBC NO<sub>2</sub>/NO<sub>3</sub> (median 29.9 μM; p = 0.002) in patients with stable CF, in contrast, were significantly higher than in control subjects. During CF exacerbations, EBC pH was further reduced (median 5.30, p = 0.017) but Fe<sub>NO</sub> and NO<sub>2</sub>/NO<sub>3</sub> were unchanged. <b>Conclusions:</b> These findings demonstrate a dissociation between EBC pH and Fe<sub>NO</sub> in inflammatory airways disease.
Implantable Cardioverter-Defibrillators, Heart Failure, and Patient Characteristics
Authors: Nicholas J. Stamato
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Word From Our Moderator
Authors: Ian Shrier
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Isocitrate dehydrogenase mutations in leukemia
Authors: Anna Sophia McKenney, Ross L. Levine
Journal: Journal of Clinical Investigation (2013)

Recent genome-wide discovery studies have identified a spectrum of mutations in different malignancies and have led to the elucidation of novel pathways that contribute to oncogenic transformation. The discovery of mutations in the genes encoding isocitrate dehydrogenase (IDH) has uncovered a critical role for altered metabolism in oncogenesis, and the neomorphic, oncogenic function of IDH mutations affects several epigenetic and gene regulatory pathways. Here we discuss the relevance of IDH mutations to leukemia pathogenesis, therapy, and outcome and how mutations in IDH1 and IDH2 affect the leukemia epigenome, hematopoietic differentiation, and clinical outcome.
Women, Sport and Performance: A Physiological Perspective
Authors: Mona M. Shangold
Journal: JAMA (1986)

This comprehensive book, by Christine L. Wells, PhD, represents an extraordinary undertaking. Only a woman as talented, bright, capable, and energetic as Dr Wells could have initiated and completed alone so voluminous a work on this subject. The author has, indeed, accomplished a monumental task and has done an excellent job. The language is clear and articulate and the book conveys a tremendous amount of information. One of the most difficult tasks for any writer is selecting an audience and directing the message to that specific audience. Although this book is intended, according to the author, for the physical education teacher, the coach, and the athlete, the language is too technical and sophisticated for most; much of the content is too technical also. Many of the terms are not defined adequately for the intended audience, and much of the content is too deep and even unnecessary for explaining the information
Abstract 2942: Acetylation of intracellular protein induces apoptotic cell death in Aspirin-treated human breast cancer cells.
Authors: Yu Ran Lee, Byeong Hwa Jeon, Sunga Choi
Journal: Cancer Research (2013)

Abstract Acetylation is one of the dynamic post-translational modification of lysine residues on protein determining the structure, function and intracellular localization that plays an important role in the signal transduction pathways related to diverse cell functions - proliferation, cell death, and differentiation as well as transcriptional regulation. Recently, it has been reported that acetylating agents including chemical histone deacetylase inhibitors and plant polyphenols lead to the increased acetylation of histone and non-histone proteins, which induces to rapid cancer cell death. In this present study, we are focused on molecular mechanism of cell death in two Aspirin-treated human breast cancer cells, MCF-7 and MDA-MB-231. Trichostatin A (TSA) treatment was combined for maintaining acetylation of intracellular proteins at 0.1 μM concentration, which was not caused cell death itself. It was observed that Aspirin/TSA treatment caused the significant inhibition of cell growth in a dose- and time-dependent manner in both MDA-MB-231 and MCF-7 cells. The induced cell death in MDA-MB-231 by Aspirin/TSA treatment was associated with several specific features of apoptosis, which were proved by biochemical assays containing DNA fragmentation, Annexin V staining and cell cycle analysis. On the other hand, the exposure of MCF-7 to Aspirin/TSA caused necrotic rather than apoptotic mechanism judged by DNA fragmentation assay. These results suggest that different cell death pathway in two breast cancer cell lines is implicated in acetylated protein mediated signals. Previous reports suggest sporadic tumor cell necrosis is associated with extracellular release of cellular protein such as the high mobility group box 1 and may activate innate immune system. Interestingly, we confirmed secretory protein in cell-culture supernatant by immunoprecipitation using anti-acetyllysin antibody. Secretion of the acetylated protein was elevated dose- and time- dependent manner after Asprin treatment. Although extracellular role of the secretory protein in response to acetylation has not been clearly identified yet, this acetylated protein may be involved in initiation of apoptotic cell death signals and/or activating innate immune response. Taken together, theses results indicated that acetylated protein plays an essential role in anti-tumorigenesis in response to acetylating agent such as Aspirin. Citation Format: Yu Ran Lee, Byeong Hwa Jeon, Sunga Choi. Acetylation of intracellular protein induces apoptotic cell death in Aspirin-treated human breast cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2942. doi:10.1158/1538-7445.AM2013-2942 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
ACUTE TONSILLAR DISEASES AND THEIR SEQUELAE.
Authors: JOSEPH H. ABRAHAM
Journal: JAMA (1900)

The tonsils belong to the hemopoietic system, and are germinating centers for the leucocytes. Their period of greatest activity is in childhood and youth, when all the lymphatic organs are especially active, and when the thymus gland is disappearing.<sup>1</sup> Surrounding the tonsillar follicles are plexuses of lymphatics, and in the tissues of the tonsils there exists an intimate lymphatic network, composed of minute channels from which the lymph is collected by larger lymphatic vessels. These pass to the superior deep cervical glands, which frequently become enlarged in tonsillar inflammations, and can be easily demonstrated in the upper part of the neck. Goodale<sup>2</sup>proved that absorption exists normally in the tonsils and takes place through the mucous membrane of the crypts. Hodenpyl<sup>3</sup>demonstrated that rarefaction of the epithelium is of constant occurrence in the tonsils; as a result of this process, parts of the epithelium are considerably diminished
Remarks on Some Points of Interest in Regard to the Presence of Sugar in the Urine
Authors: W. M. Ord
Journal: BMJ (1889)

A FEw years ago I published in the St. Thomas's Hospital Re- ports, vol.xii, some notes on glycosuria, chiefly as observed in persons who bad passed the middle age of life.The observations then recorded have been followed up and added to, and I now venture to set before you some statements and remarks in the way of supplement and illustration.These statements and re- marks must not be taken to represent final decision inl any one direction.They are, on the contrary, presented as matters to be thought about, matters which, being amplified by further note and thought, may help us to understand more of what indications in the way of diagnosis and treatment may be drawn from the oc- currence, in one case or another, of glycosuria.I trust that I shall not weary you if I review, in the outset, the conditions which may, so far as our knowledge goes, determine the presence of sugar in the urine in pathological quantity.Sum- marised as briefly as possible the conditions are: 1, excessive flux of arterial blood to the liver, and probably to other glycogenic organs; 2, defective assimilation of glucose; 3, defective formation of glycogen; 4, instability of glycogen, namely, the formation of glycogen which is too easily transformed 5, exces- sive ingestion of glucose or glucose-yielding substances.Under the first head may be gathered several kinds of cause; for example, 1, vasomotor paralysis, determined by disease or in- jury of the medullary centre or of the nerves connecting the centre with the arteries of the liver; 2, dilatation of the hepatic artery, not determined by disease of nerve centre or nerves, but by irritation in the liver, or by reflex action at the instigation of other organs, such as the stomach, or by general disorder of the circulation, functional, a result of nerve strain or excitement, functional and probably also dyscrasic, as in gout; 3, possibly also compensatory hypereemia, balancing obstruction of the arterial circulation in other parts and systems of the body.So far as I know, this possibility has not been hitherto discussed.But the converse of it appears to be pretty clearly established by actual experiment.Dr.
Points from letters: Fulminating bacterial pneumonia complicating influenza
Authors: G M Hunter
Journal: BMJ (1976)

indicates that consultants in teaching hospitals are on average of higher quality than those in peripheral hospitals and that similar considerations apply respectively to those working in the South and the North of England and also to physicians and surgeons as opposed to geriatricians and psychiatrists.If Drs Bruggen and Bourne do not believe this they should say why.There are, of course, people who believe that merit should not be financially rewarded as the work involved is cleaner and more interesting than unskilled work.There are also people who believe that it is impossible to assess merit and it would appear from the Points from LettersClinical or administrative postal addresses ?
Scene in Print: Eve Was Not the First
Authors: OSCAR JANIGER
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 June 1973Scene in Print: Eve Was Not the FirstOSCAR JANIGER, RALPH RIFFENBURGH, RONALD KERSHOSCAR JANIGERSearch for more papers by this author, RALPH RIFFENBURGHSearch for more papers by this author, RONALD KERSHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-6-984 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOur data show that the principal symptoms of the premenstrual syndrome are present in a number of diverse cultural groups, though the frequency and severity of symptoms show considerable variation among cultural groups. A few specific symptoms show a marked variation. The basis for this is not apparent in our present study. Symptoms suggestive of premenstrual distress appear to cross species as well as cultural lines occurring in several species of primates.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1973Volume 78, Issue 6Page: 984-984KeywordsPremenstrual syndrome Issue Published: 1 June 1973 PDF DownloadLoading ...
Long-Term Use of a High-Complex-Carbohydrate, High-Fiber, Low-Fat Diet and Exercise in the Treatment of NIDDM Patients
Authors: R James Barnard, Manzoor R Massey, Samuel Cherny, Lynne Trexler O'Brien, Nathan Pritikin
Journal: Diabetes Care (1983)

The purpose of this study was to assess the long-term effects of a high-complex-carbohydrate, high-fiber, low-fat diet and exercise on 69 NIDDM patients. During the initial 26-day program, fasting glucose was reduced from 179.5 +/- 10.6 to 133.5 +/- 4.0 mg/dl. This decrease in fasting glucose was achieved along with the discontinuation of oral hypoglycemic agents in 24 of 31 patients and of insulin in 13 of 18 patients; one patient was placed on insulin. Serum cholesterol and triglycerides were reduced by 25% and 27%, respectively. At 2-3 yr of follow-up, fasting glucose was not significantly different from the value observed at the end of the 26-day program. Compared with the end of the 26-day program, seven more patients were taking oral agents and four more were on insulin. Exercise and diet inventories obtained at follow-up indicated good compliance to the program and also indicated that the main difference between those patients who went back on medication at follow-up compared with those remaining off medication was the percent of calories derived from fat.
Intravenous hyperalimentation. An adjunct to treatment of malignant disease of upper gastrointestinal tract
Authors: B. Eriksson
Journal: JAMA (1980)

A prospective search for factors that would anticipate successful nutritional repletion was undertaken in patients with advanced malignant diseases of the upper gastrointestinal tract. After two weeks of intravenous hyperalimentation, increasing serum transferrin levels, total lymphocyte counts, and, to a lesser extent, arm muscle circumferences predicted an improved quality of survival, whereas declines in these factors were seen in patients who died. Skin tests, T-lymphocyte counts, albumin levels, and other anthropomorphic measurements were not predictive. The single most useful test was the serum transferrin: in only one patient did it not reflect the eventual outcome of therapy. (<i>JAMA</i>243:2049-2052, 1980)
1008. Characterization of Peripheral Regulatory T Cell Phenotype Generated in Molecular Chimeras by Gene Therapy
Authors: Jesus R. Paez-Cortez, Chaorui Tian, John Iacomini
Journal: Molecular Therapy (2006)

Introduction. Donor-specific tolerance to MHC class I antigens can be achieved following reconstitution of mice with genetically modified autologous bone marrow cells expressing allogeneic MHC class I genes. The mechanisms by which CD4 T cells that recognize allogeneic antigens through the indirect pathway are rendered tolerant involve incomplete central thymic deletion and the generation of regulatory T cells. Here we assess the peripheral regulatory T cell phenotype generated in molecular chimeras by gene therapy.
The Treatment of Classical Hemophilia With Cryoprecipitates
Authors: Paul G. Hattersley
Journal: JAMA (1966)

Four patients with classical hemophilia of various degrees of severity, and with various clinical manifestations, received factor VIII (antihemophilic globulin) concentrates prepared by the cryoprecipitate technique of Pool and Shannon. All four responded well to therapy. One required laparotomy for bleeding peptic ulcer in a Meckel's diverticulum. One developed an inhibitor of factor VIII, but responded well to increased doses of the concentrate. The activated coagulation time (ACT) of whole blood and the activated partial thromboplastin time (PTT), performed on preinfusion and postinfusion blood specimens, served well as monitors of treatment, indicating activity of the material infused and response of the patient.
Recombinant versus plasma-derived factor VIII products and the development of inhibitors in previously untreated patients with severe hemophilia A: the CANAL cohort study
Authors: Samantha C. Gouw, Johanna G. van der Bom, Günter Auerswald, Carmen Escuriola Ettinghausen, Ulf Tedgård, H. Marijke van den Berg
Journal: Blood (2007)
Sharp Bone Marrow Uptake of lndium-111 Leukocytes in a Splenectomized Patient with Sclerosing Cholangitis
Authors: ELIZABETH OATES, ROBERT C. SARNO
Journal: Clinical Nuclear Medicine (1988)

lndium-111-labeled leukocyte imaging was performed on a splenectomized patient with end-stage cirrhosis. The scan demonstrated a small accessory spleen and markedly increased bone marrow activity. Given the lack of normally functioning spleen and liver, the most likely mechanisms accounting for this unusual pattern are: 1) redistribution of marginating labeled cells to the marrow and, 2) increased trapping by the marrow reticuloendothelial system of damaged cells normally sequestered by the spleen and liver.
Report on the Duke University Medical Center Private Sector Conference
Authors: John K. Iglehart
Journal: New England Journal of Medicine (1982)

The American medical-care system is caught in a tightening bind between society's limited resources and its open-ended commitment to provide the poor and elderly ready access to tax-financed care through Medicaid and Medicare. Society's agent, the government, is moving to reconcile this dilemma, but its early steps are placing intense pressure on medical-care providers — particularly on institutions that render substantial service to the impoverished — without effectively moderating the demand for such service.Searching for ways to address this issue, the participants at the seventh Private Sector Conference in Medicine,* sponsored by Duke University Medical Center and held in . . .
A Further Report on Lung Resection for Pulmonary Tuberculosis
Authors: B. J. Bickford, F. R. Edwards, J. R. Esplen, J. G. Gifford, O. F. Thomas
Journal: Thorax (1952)

CASEOUS NODULES.If these lesions are more than 1 cm. in diameterand persist longer than a year we advise excision.Many are closed; others have small and usually intermittent bronchial com- munications.If smears are made of the contents of the nodule, they will almost always show a high concentration of tuLbercle bacilli.We con- on July 20,
Hereditary Progressive Atrioventricular Conduction Defect
Authors: Henry T. Lynch, Syed Mohiuddin, Michael H. Sketch, Anne J. Krush, Stephen Carter, Vincent Runco
Journal: JAMA (1973)

We studied a syndrome involving a progressive atrioventricular conduction defect in three generations of a large family. Clinical findings included a slow heart rate, episodes of lightheadedness, syncope, and absence of predisposing acquired or hereditary cardiac disorders. Electrocardiography showed a prolonged atrioventricular conduction with onset usually in the 30s, loss of R waves in the right precordial leads, and arrhythmia that occurs only as a late manifestation. Progression from first-degree to complete heart block was usually slow, but occasionally a fulminant course led to sudden death within two or three years. Specific differences from other forms of conduction defects suggest that this is a new hereditary syndrome.
Post-"pill" amenorrhoea--cause or coincidence?
Authors: H S Jacobs, U A Knuth, M G Hull, S Franks
Journal: BMJ (1977)

The relationship of contraceptive history to diagnostic category of amenorrhoea was analysed in 131 consecutively investigated cases of secondary amenorrhoea. Amenorrhoea occurred in 52 patients immediately after discontinuing the oral contraceptive. Twenty-two had had amenorrhoea before oral contraceptive treatment and 23 patients before the episode of non-contraceptive-related amenorrhoea investigated here. When these cases were excluded from analysis there was no significant difference in the distribution of any of the diagnostic categories between those who had used the oral contraceptive and those who had not. The results suggest that using oral contraceptives does not cause subsequent amenorrhoea.
Intra-articular administration of gelatin hydrogels incorporating rapamycin–micelles reduces the development of experimental osteoarthritis in a murine model
Authors: Tokio Matsuzaki, Takehiko Matsushita, Yasuhiko Tabata, Takashi Saito, Tomoyuki Matsumoto, Kanto Nagai, Ryosuke Kuroda, Masahiro Kurosaka
Journal: Biomaterials (2014)
THE ASSOCIATION OF LDL CHOLESTEROL WITH CARDIOVASCULAR DISEASE MORTALITY IN A LOW-RISK POPULATION WITH TWO DECADES OF FOLLOW-UP: RESULTS FROM THE COOPER CENTER LONGITUDINAL STUDY
Authors: Shuaib Abdullah, David Leonard, Jarett Berry, Benjamin Willis, Laura Defina, Darren McGuire, James de Lemos, Amit Khera
Journal: Journal of the American College of Cardiology (2013)