A Study of the Juxtaglomerular Body in Primary Aldosteronism
Authors: RICHARD J. COHEN
Journal: Annals of Internal Medicine (1965)

Case Studies1 March 1965A Study of the Juxtaglomerular Body in Primary AldosteronismRICHARD J. COHEN, RICHARD C. SEVERANCE, EDWARD G. WHITING, GEORGE D. LUNDBERGRICHARD J. COHENSearch for more papers by this author, RICHARD C. SEVERANCESearch for more papers by this author, EDWARD G. WHITINGSearch for more papers by this author, GEORGE D. LUNDBERGSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-3-569 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has been postulated recently that an interdependent system involving renin, angiotensin, and aldosterone may be involved in the production of certain types of human hypertension (1, 2). A number of studies have demonstrated an interaction of renin with angiotensin I to form angiotensin II (3-5), which stimulates aldosterone secretion by the zona glomerulosa of the adrenal cortex (3, 6-8). Aldosterone, by means of its potent mineralocorticoid effect on sodium and potassium balance, produces an elevation in systemic arterial blood pressure (2-9). The use of microdissection (10-13) and fluorescent antibody techniques (14) has localized renin production to the juxtaglomerular body...References1. ITSKOVITZHILDRETHSELLERSBLAKEMORE HDEAAMWS: The granularity of the juxtaglomerular cells in human hypertension—histologic and clinical correlation. Ann. Intern. Med. 59: 8, 1963. LinkGoogle Scholar2. LARAGH JH: Inter-relationships between angiotensin, norepinephrine, epinephrine, aldosterone secretion and electrolyte metabolism in man. Circulation 25: 203, 1962. CrossrefMedlineGoogle Scholar3. DAVISHARCROFTTITUSCARPENTERAYERSSPIEGEL JOPMEOCCCRHE: The role of the renin-angiotensin system in the control of aldosterone secretion. J. Clin. Invest. 41: 378, 1962. CrossrefMedlineGoogle Scholar4. 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