tbuckley/cabot-search huggingface dataset:
Primary upper‐extremity deep vein thrombosis: High prevalence of thrombophilic defects
Authors: Mariela F. Hendler, Susana S. Meschengieser, Alicia N. Blanco, Maria F. Alberto, Maria J. Salviú, Laura Gennari, Maria A. Lazzari
Journal: American Journal of Hematology (2004)

Abstract Primary deep venous thrombosis of the upper extremity (UEDVT) is an unusual disorder. Limited data are available on the contribution of hypercoagulable status in the pathogenesis of this disease. This study aims to report the prevalence of inherited and acquired thrombophilic risk factors (TF) in patients with primary (effort‐related and spontaneous) UEDVT. From 1993 to 2002, 31 patients (17 females, median age 38.8 years, range 16–60 years; and 14 males, median age 31.4 years, range 20–56 years) with primary UEDVT ( n = 15 effort‐related and n = 16 spontaneous) were referred for screening of hypercoagulable status. Nineteen (61.3%) patients had at least one coagulation abnormality. The most common acquired TF were antiphospholipid antibodies (31% lupus anticoagulant and 12.9% anticardiolipin antibodies). Factor V Leiden (12.9%) and prothrombin G20210A mutation (20%) were the most prevalent genetic risk factors. Five patients (16.1%) had high plasma homocysteine levels, and one patient (4.7%) had protein S deficiency. Effort‐related UEDVT was associated with male gender ( P = 0.04) and younger age ( P = 0.02). There was no significant difference in the prevalence of acquired or inherited TF between patients with effort‐related or spontaneous UEDVT. A local anatomic abnormality was detected in seven patients (22.5%), and the prevalence of TF was significantly lower within this group ( P = 0.006). The incidence of TF in patients without an anatomic abnormality was 75% (RR 5.25). This study found a high prevalence of an underlying thrombophilic status in spontaneous and effort‐related UEDVT. Hypercoagulable status may play a significant role in both groups. Screening for local anatomical abnormalities and thrombophilia should be included in the evaluation of primary UEDVT. Am. J. Hematol. 76:330–337, 2004. © 2004 Wiley‐Liss, Inc.
Tetracycline and Thyroid Function
Authors: Kenneth L. Becker
Journal: JAMA (1967)

Animal studies have suggested that tetracyclines may exert an antithyroid action, although reports have been contradictory.<sup>1-5</sup>The effect of tetracycline therapy on the human thyroid has not been investigated. Because of the obvious clinical importance of documenting any antithyroid effects in man, a study of thyroid function was undertaken before and following 11 consecutive days of tetracycline hydrochloride administration. <h3>Method and Materials</h3> Fourteen ambulatory male patient volunteers between the ages of 36 and 67 years were given 2 gm daily of tetracycline hydrochloride (Achromycin V) orally in four divided doses for a period of 11 days. Each patient served as his own control. Those patients selected were not acutely ill or debilitated, had no evidence of thyroid, renal or hepatic disease, or congestive heart failure, and had no recent intake of diagnostic or therapeutic iodides. Prior to tetracycline treatment, blood was drawn for duplicate protein-bound iodine (PBI) and cholesterol
Sleep Loss and Fatigue in Residency Training
Authors: Sigrid Veasey, Raymond Rosen, Barbara Barzansky, Ilene Rosen, Judith Owens
Journal: JAMA (2002)

Reduced sleep time is commonplace for many interns and residents. Recent studies, however, suggest that sleep loss and fatigue result in significant neurobehavioral impairments in healthy young adults. We reviewed studies addressing the effects of sleep loss on cognition, performance, and health in surgical and nonsurgical residents. We describe the effectiveness of countermeasures for sleepiness, including recent work-hour restrictions. A more complete understanding of the issues of sleep loss during residency training can inform innovative strategies to minimize the effects of sleepiness and fatigue on patient care and resident safety.
Nutrition in Health and Disease
Authors: Esther S. Nelson
Journal: JAMA (1982)

Nutrition is a science of the 20th century, and this book covers much of what has been learned since the US Department of Agriculture published bulletin 28 in 1906, containing in 85 small pages an analysis of practically all foodstuffs available. Bulletin 28 gave percentages of carbohydrate, fat, protein, ash, and water and was so complete it was thought that all was known about food that ever would be known. How wrong they were is evidenced by the book being reviewed here, which contains about 800 pages filled with results of years of research on the subject.  Important as it is to health, instruction in nutrition is still the stepchild of the medical school curriculum. Hence, this book has not been written by doctors of medicine, but by individuals highly trained in the science of nutrition.  The chapters cover much organic chemistry of our basic foodstuffs. Each chapter reveals the
THE FUNCTION OF THE RIGHT TEMPORO-SPHENOIDAL LOBE.Read before the Section of Neurology and Medical Jurisprudence at the Forty-fourth Annual Meeting of the American Medical Association.
Authors: WM. J. HERDMAN
Journal: JAMA (1893)

In an authoritative work on Diseases of the Nervous System recently published, the temporal lobe of the brain on the right side in man is spoken of as one of the latent regions of the brain, destruction of which, and irritation of which, produce no special or distinctive phenomena. Clinical and pathological evidence bearing upon the functions of the temporal lobes is acknowledged to be scanty at present by no less a specialist on this subject than David Ferrier; and the discrepancies in the results of the many experimental researches upon animals conducted by him, Victor Horsley, and other observers of undoubted merit, cause us to welcome any additional light, however meager, that will aid in clearing up the darkness that still surrounds this region of the human brain. A most novel and interesting case recently came under my observation in consultation, which terminated fatally within five weeks from the
The presence of both bone sialoprotein-binding protein gene and collagen adhesin gene as a typical virulence trait of the major epidemic cluster in isolates from orthopedic implant infections
Authors: Davide Campoccia, Pietro Speziale, Stefano Ravaioli, Ilaria Cangini, Simonetta Rindi, Valter Pirini, Lucio Montanaro, Carla Renata Arciola
Journal: Biomaterials (2009)
The Use of Trazodone in Psychosomatic Medicine
Authors: Mauricio Knobel
Journal: Psychotherapy and Psychosomatics (1974)

A new antidepressant A.F.-1161, a hydrochloride derivative of triazolpiridine or Trazodone, was utilized in several psychosomatic disorders. The previously proved low toxicity, tranquilizing and antidepressive effects of this product, led us to try its usefulness in psychosomatic diseases, where the depressive component can be demonstrated. Thus, we selected 100 'somatic' patients who showed depressive signs on the Hamilton Rating Scale for Depression and submitted them to Trazodone or placebo, following the double-blind technique. Considerations on the relationship between somatic disorders and depressive states are presented in order to explain the positive results obtained in this research.
Abstract 2055: miR-17-3p suppresses tumorigencity of prostate cancer through inhibiting mitochondrial antioxidant enzymes
Authors: Yong Xu, Fang Fang, Sajni Josson, Daret K. St. Clair, William H. St. Clair
Journal: Cancer Research (2010)

Abstract Aberrant micro RNA (miRNA) expression has been implicated in pathogenesis of cancer. Recent studies have shown that miR-17-92 cluster is overexpressed in many types of cancer (Venturini et al Blood 2007; Mendell Cell 2008). The oncogenic function of mature miRNAs encoded by the miR17-92 cluster was identified from the 5’ arm of six precursor including miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1, and miR-92-1. However, function of the miRNAs produced from the 3’ arm of these precursors remains to be elucidated. The present study demonstrates that miR-17-3p is able to suppress multiple primary mitochondrial antioxidant enzymes including manganese superoxide dismutase (MnSOD or SOD2), glutathione peroxidase-2 (GPX2), and thioredoxin reductase-2 (TXNRD2). Transfection of miR17-3p into prostate cancer PC-3 cells significantly reduced levels of the three antioxidant proteins and activity of the luciferase reporter under the control of identified miR-17-3p blinding sequences located in the 3’-untranslated regions of the three target genes. Disulfiram, a drug used to treat chronic alcoholism and also shown to have anticancer effect, induces the level of mature miR-17-3p and apoptotic cell death in PC-3 cells, which can be attenuated by transfection of antisense miR-17-3p. Increasing miR17-3p level in PC-3 cell by a Tet-on-based conditional expression system markedly suppressed its tumorigencity and enhanced its radiosensitivity. These results suggest that miR-17-3p may suppress aggressiveness of prostate cancer through inhibition of mitochondrial antioxidant enzymes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2055.
Gastrointestinal Bleeding and Arthropathy
Authors: Jack Wittenberg
Journal: JAMA (1966)

Dr. Frank J. Gallia: This 51-year-old man entered the hospital with a history of epigastric pain, dark stools for several weeks, and a one-week history of vomiting small amounts of dark red blood. His history included a generous alcoholic intake and a recent 25-lb (11.4 kg) weight loss. He had recently had incision of a painful right shoulder; a culture of the fluid revealed both staphylococcus and streptococcus. Physical examination revealed a febrile, thin man with a grayish hue to his skin. There were dark deposits on the sclerae of both eyes.  Laboratory data included a hematocrit value of 18%; amylase, 48 units/ml; prothrombin time, 50%; ammonia, 100μg/100 cc; blood urea nitrogen (BUN), 9 mg/100 cc; creatinine, 0.6 mg/100 cc. An upper-gastrointestinal-tract series was done.  Discussion  Dr. Laurence L. Robbins: Dr. Tomchik, do you want to make any comment?  Dr. Frederick S. Tomchik: The proximal stomach does not seem to
Montelukast treatment may alter the early efficacy of immunotherapy in children with asthma
Authors: Paweł Majak, Błażej Rychlik, Łukasz Pułaski, Andrzej Błauż, Brzozowska Agnieszka, Monika Bobrowska-Korzeniowska, Piotr Kuna, Iwona Stelmach
Journal: Journal of Allergy and Clinical Immunology (2010)
Insulin and cholesterol gallstones: New insights for a complex pathogenic relationship
Authors: Silvana Zanlungo, Juan Francisco Miquel, Attilio Rigotti, Flavio Nervi
Journal: Hepatology (2008)

Biddinger SB, Haas JT, Yu BB, Bezy O, Jing E, Zhang W, Unterman TG, Carey MC, Kahn CR. Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nat Med 2008;14:778–782. Abstract Available at: http://www.nature.com/nm/journal/v14/n7/abs/nm1785.html
Optimization of retroviral vector-mediated gene transfer into endothelial cells in vitro.
Authors: M L Kahn, S W Lee, D A Dichek
Journal: Circulation Research (1992)

Retroviral vector-mediated gene transfer into endothelial cells is relatively inefficient with transduction rates as low as 1-2% in vitro and even lower in vivo. To increase the efficiency of gene transfer into endothelial cells, we used retroviral vectors expressing beta-galactosidase and urokinase and measured endothelial cell transduction efficiencies with quantitative assays for beta-galactosidase and urokinase protein. We evaluated several techniques reported to improve the efficiency of retroviral transduction in vitro, including 1) extended periods of exposure to vector, 2) repeated exposures to vector, 3) maximization of the ratio of vector particles to endothelial cells by increasing the volume and concentration of vector particles or by decreasing the number of endothelial cells exposed, 4) cocultivation of endothelial cells with vector-producing cells, and 5) variation of the type and concentration of polycation used with the retroviral vector. Only the use of more concentrated (higher titer) vector-containing supernatant and the use of the polycation DEAE-dextran improved the efficiency of gene transfer into endothelial cells in vitro. In an optimized transduction protocol, a 60-second exposure to 1 mg/ml DEAE-dextran followed by a single 6-hour exposure to supernatant of a titer of 10(5)-10(6) colony-forming units/ml resulted in transduction efficiencies of 50-90% with both vectors. Decreasing the time of the supernatant exposure to 15 minutes permitted transduction efficiencies of 15-20% while significantly minimizing the duration of the transduction. Therefore, the optimized protocol allows high efficiency in vitro gene transfer into endothelial cells within several hours. The briefer protocol may prove useful for in vivo gene transfer in which the time of exposure to the supernatant is limited.
Comparison of vascular tone during combined haemodialysis with ultrafiltration and during ultrafiltration followed by haemodialysis: a possible mechanism for dialysis hypotension.
Authors: J R Bradley, D B Evans, A J Cowley
Journal: BMJ (1990)

prospective double blind trial. Gut 1988;92:42S-32. 5 Leuschner U, Hellstern A, Fischer H, Schmidt K, Leuschner M. Methyl tert-butyl ether lor gallstone dissolution, clinical results and loxicity. Castroenierology 1989;97 suppl,i:A621. 6 Kellett A?J, Wickham JFA, Russell RCG. Percutaneous cholecvstolithotomy. fir Aied/1988;296:453-5. 7 Wickham JHA. Miller RA. Percutaneous renal surgery. London: Churchill Livingstone, 1983. 8 Villanova N, Ba/zoli F, Taroni F, et al. Gallstone recurrence after successful oral bile acid treatment. A 12 year follow up study and evaluation of long term post dissolution treatment. Gastroenierology 1989;97:726-31. 9 Pers M, Baden H. On the frequency of recurrence of calculi in the gallbladder after cholecystolithotomy. Acta ChirScand 1952;102:260-6. 10 Norrby S, Schonebeck J. Long term results with cholecystolithotomy. Acta ChirScand 1970;136:711-3. 11 Anonymous. Gallstones, bile acids and the li\er [Editorial]. Lancet 1989;ii:249-51.
22 GRANULOCYTE-COLONY STIMULATING FACTOR (G-CSF) THERAPY COULD IMPROVE SURVIVAL IN PATIENTS WITH ACUTE-ON-CHRONIC LIVER FAILURE (ACLF) – A RANDOMIZED PLACEBO CONTROLLED TRIAL
Authors: V. Garg, A. Kumar, H. Garg, B.C. Sharma, N. Trehanpati, S.K. Sarin
Journal: Journal of Hepatology (2010)
Biochemistry of Collagen
Authors: H. R. Catchpole
Journal: JAMA (1977)

Both the editorship and the roster of contributors practically ensure the general excellence of this Biochemistry of Collagen . An advanced treatise hewing closely to the title, it should be an invaluable source book in this active field. Clinical correlations are somewhat sparse but worth digging out. Covered are primary structure, molecular structure and packing into fibrils, cross-linking, biosynthesis, immunology, collagenases, molecular pathology, collagen and cell differentiation, and collagen model building. Some of these chapters are presented in excessive detail.  While collagen is indeed ubiquitous and abundant, much of the collagen actually studied to date represents either small soluble fractions of the total bulk of collagen, or collagens derived from embryos, tissue cultures, or lathyritic animals and possibly not representative of the whole. The iron fist of consensus is a bit heavy at times: thus, the mode of collagen biosynthesis is racked into the Palade mold of protein for export at
Adding single-point acupuncture to physiotherapy for painful shoulder improved function and reduced pain
Authors: Timothy S. Carey
Journal: Annals of Internal Medicine (2008)

Source Citation Vas J, Ortega C, Olmo V, et al. Single-point acupuncture and physiotherapy for the treatment of painful shoulder: a multicentre randomized controlled trial. Rheumatology (Oxford). 2008;47:887-93. 18403402
Abstract DDT01-01: Discovery of CGM097 as a novel Mdm2 inhibitor
Authors: Keiichi Masuya, Pascal Furet, Stefan Stutz, Philipp Holzer, Carole Pissot-Soldmann, Nicole Buschmann, Thérèse Valat, Stéphane Ferretti, Stephan Ruetz, Caroline Rynn, Joerg Berghausen, Edgar Jacoby, Marc Lang, Tobias Gabriel, Francesco Hofmann, Joerg Kallen, Sébastien Jeay, Francois Gessier
Journal: Cancer Research (2014)

Abstract The antiproliferative transcriptional activity of the p53 tumor suppressor is inhibited by the binding of its transactivation domain to the regulator protein Mdm2. Overexpression of Mdm2 or amplification of its gene, leading to a loss of p53 function, has been observed in various tumors. An attractive approach to restore p53 activity in such tumors and to inhibit their growth is to prevent the association of the two proteins by blocking the p53 binding pocket of Mdm2 with a small molecule. In this presentation, we report how the starting point of CGM097 was discovered and how innovative medicinal chemistry efforts led to further optimization of the potency and physico-chemical properties, resulting in CGM097, a novel, highly optimized, and selective inhibitor of the p53-Mdm2 interaction. Citation Format: Keiichi Masuya, Pascal Furet, Stefan Stutz, Philipp Holzer, Carole Pissot-Soldmann, Nicole Buschmann, Thérèse Valat, Stéphane Ferretti, Stephan Ruetz, Caroline Rynn, Joerg Berghausen, Edgar Jacoby, Marc Lang, Tobias Gabriel, Francesco Hofmann, Joerg Kallen, Sébastien Jeay, Francois Gessier. Discovery of CGM097 as a novel Mdm2 inhibitor. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr DDT01-01. doi:10.1158/1538-7445.AM2014-DDT01-01
Exploring a New Twist on Tumor Metastasis
Authors: Jing Yang, Sendurai A. Mani, Robert A. Weinberg
Journal: Cancer Research (2006)

Abstract Unraveling the genetic programs that drive -metastasis may offer insights into how to limit or prevent this deadly aspect of cancer progression. Our recent studies indicate that tumor cell metastasis involves the activity of the transcription factor, Twist, which regulates epithelial-mesenchymal transition and early embryonic morphogenesis. Here, we review the Twist signaling pathway during normal development and discuss how the transcription factor Twist and the epithelial-mesenchymal transition program impinge their biological functions during tumor metastasis. (Cancer Res 2006; 66(9): 4549-52)
United We Stand — Divided We Fall
Authors: John Lister
Journal: New England Journal of Medicine (1959)

IN a recently published book, Call the Doctor: A social history of medical men (London: Michael Joseph, 1958), Mr. E. S. Turner has drawn a portrait of the doctor through the ages as a member of society. The author admits that, being a layman, he has never dissected a leg, certified a lunatic or been called from his bed to sniff the breath of an abusive alderman. However, he has not attempted to write a history of medicine, but in his character study he has shown how the doctor, in spite of his high calling, has often been a controversial . . .
A New Agenda for Women's Health
Authors: Rebecca Voelker
Journal: JAMA (1994)

FOR YEARS, advocates have emphasized that the dimensions of women's health go far beyond functions of the ovaries and uterus. Now, a broad-based group of experts is pushing for a new focus on the behavioral and psychosocial factors that affect women's health. Led by officials of the American Psychological Association (APA), the experts convened in Washington, DC, for the first national conference aimed at developing a specific agenda to address the psychosocial aspects of women's health care. "The group is using feedback from the conference's participants and advisory committee to draft an agenda that we hope will be available by September," says Gwendolyn Puryear Keita, PhD, director of the APA's Women's Programs Office. Keita pointed out that the agenda is important as a guide in establishing research funding and programming priorities at the federal level. The APA plans to present the agenda to Congress, Keita said, "because we're trying to
Panel Advises Tougher Limits on Lead Exposure
Authors: Bridget M. Kuehn
Journal: JAMA (2012)

view is not just trumpeting a slight movement of BMI. “Reviews such as ours can provide a clear lens in relation to what information we have and don’t have, where research has and hasn’t been directed, who is funding what types of research, and whether program developers are developing programs [for] individuals and populations,” Waters said. “We aim to update this review with an additional review of the evidence in relation to policies and legislative strategies, which will provide important accompanying information.”
Effects of continuous high dose rhgm‐csf infusion on human monocyte activity
Authors: Raymond C. Perkins, Saroj Vadhan‐Raj, Ronald K. Scheule, Raymond Hamilton, Andrij Holian
Journal: American Journal of Hematology (1993)

Abstract In this study we describe the time‐dependent effects of a high dose (750 (μg/ml/24 hr) continuous infusion of recombinant human granulocyte‐macrophage colony‐stimulating factor (rhGM‐CSF) on monocyte number, cytokine release, and superoxide anion production. Blood was taken from patients prior to rhGM‐CSF infusion (day 0), and on days 1,7, and 14 of infusion. The mean concentration of monocytes per ml of blood increased progressively from 4.3 × 10 5 on day 0 to 21 × 10 5 on day 14 of infusion. There was no significant change in the basal release of tumor necrosis factor α (TNF‐α) or interleukin 1β (IL‐1β) induced by rhGM‐CSF. However, the lipopolysaccharide (LPS)‐stimulated release of TNF‐α by monocytes increased significantly on day 1 of infusion, and by day 14 had increased 8‐fold. IL‐1β release from LPS‐stimulated monocytes increased slightly by day 7, and by almost 10‐fold by day 14 of infusion. When maximally stimulated with phorbol dibutyrate, the monocytes demonstrated an increased (although not significant) capacity to produce superoxide anion on days 7 and 14 of infusion. No change in basal superoxide anion production was seen at any day of infusion. These GM‐CSF‐induced changes in stimulated cytokine and superoxide anion release could not be reproduced by treating monocytes with rhGM‐CSF in vitro. In summary, a two week, high dose infusion of rhGM‐CSF resulted in increases in circulating monocyte concentration, and in the stimulated release of TNF‐α and IL‐1β, and superoxide anion production from these monocytes. These primed monocytes could enhance the ability of neutropenic patients to fight infection.
Atmospheric Pollution with Halothane during Outpatient Dental Anaesthesia
Authors: L. Strunin, J. M. Strunin, C. C. Mallios
Journal: BMJ (1973)

Pollution of the atmosphere with halothane has been measured during general anaesthesia for outpatients undergoing dental extractions. The level of contamination was far in excess of that recorded in surgical operating theatres, and halothane was inhaled at similar concentrations by both the anaesthetist and the dental surgeon. The room air-changing system and a local fan had little effect on contamination. Scavenging devices on the exhalation valve of the anaesthetic circuit were only moderately effective in reducing the concentration of halothane in the atmosphere.
Persistent acantholytic dermatosis related to actinic damage
Authors: H.A. FAWCETT, JONATHAN A.MILLER
Journal: British Journal of Dermatology (1983)

Ten male patients aged 38-63 years are presented, in whom a chronic, itchy, papular eruption developed on the upper trunk. Histology showed the characteristic features of Darier's disease. All the patients had clinical evidence of considerable solar damage and skin malignancies were frequently present. The condition is thought to represent a distinct entity which has been called persistent acantholytic dermatosis. The relationship between this condition, transient acantholytic dermatosis and actinic keratoses with Darier-like histology is discussed.