tbuckley/cabot-search huggingface dataset:
New Source for Information on Rare Diseases
Authors: Mike Mitka
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AIDS Vaccine for Asia Network (AVAN): Expanding the Regional Role in Developing HIV Vaccines
Authors: Stephen J. Kent, David A. Cooper, Mean Chhi Vun, Yiming Shao, Linqi Zhang, Nirmal Ganguly, Budiman Bela, Hiko Tamashiro, Rossana Ditangco, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Nguyen Van Kinh, Alan Bernstein, Saladin Osmanov
Journal: PLoS Medicine (2010)

The Health in Action section is a forum for individuals or organizations to highlight their innovative ap-
Adoptive Immunotherapy of Disseminated Leukemia With TCR-transduced, CD8+ T Cells Expressing a Known Endogenous TCR
Authors: Michelle L Dossett, Ryan M Teague, Thomas M Schmitt, Xiaoxia Tan, Laurence JN Cooper, Cristina Pinzon, Philip D Greenberg
Journal: Molecular Therapy (2009)

Adoptive T-cell immunotherapy has shown promise in the treatment of human malignancies, but the challenge of isolating T cells with high avidity for tumor antigens in each patient has limited application of this approach. The transfer into T cells of T-cell receptor (TCR) genes encoding high-affinity TCRs recognizing defined tumor-associated antigens can potentially circumvent this obstacle. Using a well-characterized murine model of adoptive T-cell immunotherapy for widely disseminated leukemia, we demonstrate that TCR gene-modified T cells can cure mice of disseminated tumor. One goal of such adoptive therapy is to establish a persistent memory response to prevent recurrence; however, long-term function of transferred TCR-transduced T cells is limited due to reduced expression of the introduced TCR in vivo in quiescent resting T cells. However, by introducing the TCR into a cell with a known endogenous specificity, activation of these T cells by stimulation through the endogenous TCR can be used to increase expression of the introduced TCR, potentially providing a strategy to increase the total number of tumor-reactive T cells in the host and restore more potent antitumor activity.
Histopathological diagnosis of onychomycosis by periodic acid-Schiff-stained nail clippings
Authors: E-M. Reisberger, C. Abels, M. Landthaler, R-M. Szeimies
Journal: British Journal of Dermatology (2003)

Summary Background The current laboratory methods for diagnosing fungal infections of the nails are the potassium hydroxide (KOH) scraping technique and fungal culture. However, due to the long incubation period required for fungal culture and the reported rate of approximately 30% false negative results observed when using these methods, a quick and highly specific screening test for diagnosing onychomycosis is urgently needed.
Distinct MHC class I–dependent NK cell–activating receptors control cytomegalovirus infection in different mouse strains
Authors: Michał Pyzik, Benoit Charbonneau, Eve-Marie Gendron-Pontbriand, Marina Babić, Astrid Krmpotić, Stipan Jonjić, Silvia M. Vidal
Journal: The Journal of Experimental Medicine (2011)

Recognition of mouse cytomegalovirus (MCMV)–infected cells by activating NK cell receptors was first described in the context of Ly49H, which confers resistance to C57BL/6 mice. We investigated the ability of other activating Ly49 receptors to recognize MCMV-infected cells in mice from various H-2 backgrounds. We observed that Ly49P1 from NOD/Ltj mice, Ly49L from BALB mice, and Ly49D2 from PWK/Pas mice respond to MCMV-infected cells in the context of H-2Dk and the viral protein m04/gp34. Recognition was also seen in the H-2d and/or H-2f contexts, depending on the Ly49 receptor examined, but never in H-2b. Furthermore, BALB.K (H-2k) mice showed reduced viral loads compared with their H-2d or H-2b congenic partners, a reduction which was dependent on interferon γ secretion by Ly49L+ NK cells early after infection. Adoptive transfer of Ly49L+, but not Ly49L−, NK cells significantly increased resistance against MCMV infection in neonate BALB.K mice. These results suggest that multiple activating Ly49 receptors participate in H-2–dependent recognition of MCMV infection, providing a common mechanism of NK cell–mediated resistance against viral infection.
A Reevaluation of Risk of In Utero Exposure to Lithium
Authors: Lee S. Cohen
Journal: JAMA (1994)

<h3>Objective.</h3> —To reevaluate the risk associated with in utero exposure to lithium. <h3>Data Sources and Study Selection.</h3> —Data were obtained from all published studies, in multiple languages, referenced in MEDLINE, Toxline, and the Lithium Information Center databases. Unpublished studies were not included. The search terms were<i>lithium, pregnancy, teratogen, abnormalities (drug induced), Ebstein's anomaly</i>, and<i>adverse effects</i>. <h3>Data Extraction and Synthesis.</h3> —In the 1970s a very strong association was suggested between maternal lithium treatment during pregnancy and Ebstein's anomaly of the heart in the offspring. The relative risk for Ebstein's anomaly among such children was estimated to be 400 on the basis of data collected from a registry of voluntarily submitted cases. More recent controlled epidemiologic studies have consistently shown a lower risk. No women who took lithium during pregnancy were found among four case-control studies of Ebstein's anomaly involving 25, 34, 59, and 89 affected children, respectively. In two cohort studies, risk ratios of 3.0 (95% confidence interval [CI], 1.2 to 7.7) and 1.5 (95% CI, 0.4 to 6.8) for all congenital anomalies have been observed. The risk ratios for cardiac malformations in these studies were 7.7 (95% CI, 1.5 to 41.2) and 1.2 (95% CI, 0.1 to 18.3), respectively. <h3>Conclusion.</h3> —While initial information regarding the teratogenic risk of lithium treatment was derived from biased retrospective reports, more recent epidemiologic data indicate that the teratogenic risk of first-trimester lithium exposure is lower than previously suggested. The clinical management of women with bipolar disorder who have childbearing potential should be modified with this revised risk estimate. (<i>JAMA</i>. 1994;271:146-150)
The Measurement of the Q-T Interval of the Electrocardiogram
Authors: EUGENE LEPESCHKIN, BORYS SURAWICZ
Journal: Circulation (1952)

The sources of error in determination of the beginning of QRS and the end of T during measurement of the Q-T duration are analyzed. An important error is confusion of an elevated U wave with the T wave, resulting in the diagnosis of a prolonged Q-T. In such cases, some of the precordial leads usually show a notch or kink between T and U which indicates approximately the end of T. If these criteria are used, the true corrected Q-T duration in hypopotassemia without hypocalcemia is not prolonged, but normal or shortened, corresponding to an earlier appearance of the second heart sound.
Book Review When Bodies Remember: Experiences and Politics of AIDS in South Africa (California Series in Public Anthropology. 15.) By Didier Fassin. Translated by Amy Jacobs and Gabrielle Varro. 365 pp. Berkeley, University of California Press, 2007. $55 (cloth); $21.95 (paper). 978-0-520-24467-2 (cloth); 978-0-520-25027-7 (paper).
Authors: Glenda Gray
Journal: New England Journal of Medicine (2007)
Immigrants and Health Care — At the Intersection of Two Broken Systems
Authors: Susan Okie
Journal: New England Journal of Medicine (2007)

At a primary care clinic in Montgomery County, Maryland, where I volunteer, the patients are uninsured immigrants from Latin America or West Africa. Many are day laborers, house cleaners, or construction workers; most do not speak English. Several months ago, I saw a middle-aged Hispanic baker with profound weakness, fatigue, limb swelling, and severe muscle pain, who had to be hospitalized for myxedema. Fortunately, a local charity agreed to pay most of her hospital costs, and she's now receiving thyroid hormone–replacement therapy — but with regular care, her hypothyroidism could have been diagnosed earlier and hospitalization averted. Another day, I . . .
Coronary artery fistula in the heart transplant patient. A potential complication of endomyocardial biopsy.
Authors: J S Sandhu, B F Uretsky, T R Zerbe, A S Goldsmith, P S Reddy, R L Kormos, B P Griffith, R L Hardesty
Journal: Circulation (1989)

All follow-up annual cardiac catheterizations performed on recipients of orthotopic heart transplant were reviewed, and 14 patients with coronary artery fistula were identified. The prevalence (8.0%, 14 of 176 patients) was strikingly higher than that for patients without transplant (0.2%) who underwent routine cardiac catheterization. These 14 patients had 21 coronary artery fistulas: single in nine and multiple in five patients. Fifty-two percent arose from the right, 43% from the left anterior descending, and 5% from the circumflex coronary artery. All drained into the right ventricle. Four patients underwent oximetric evaluation, and left-to-right shunting was not detectable. No patient had symptoms attributable to the fistula. Hemodynamic measurements were similar to those of a control group of 28 age- and sex-matched recipients of heart transplant without coronary artery fistula; however, the cardiac index (p = 0.02) and pulmonary artery oxygen saturation (p = 0.03) were significantly higher, and the arteriovenous oxygen difference (p = 0.01) was significantly lower in the group with coronary artery fistula. The histologic features of rejection, large arterioles, or epicardial fat on any biopsy specimen predating coronary artery fistula diagnosis were not associated with the development of the fistula when the two groups were compared. Nine patients (11 coronary artery fistulas) had follow-up studies performed, and three fistulas were larger, three were unchanged, two were smaller, and three had resolved. No complications of coronary artery fistula developed during a mean follow-up of 28 months (range, 12-42 months).(ABSTRACT TRUNCATED AT 250 WORDS)
Compartmentalization of TNF Receptor 1 Signaling
Authors: Wulf Schneider-Brachert, Vladimir Tchikov, Jens Neumeyer, Marten Jakob, Supandi Winoto-Morbach, Janka Held-Feindt, Michael Heinrich, Oliver Merkel, Martin Ehrenschwender, Dieter Adam, Rolf Mentlein, Dieter Kabelitz, Stefan Schütze
Journal: Immunity (2004)
Book Review Green's Gynecology: Essentials of clinical practice Fourth edition. Edited by Daniel L. Clarke-Pearson and M. Yusoff Dawood. 604 pp., illustrated. Boston, Little, Brown, 1990. $39.50. Gynecology: A practical approach By Victor Gomel and Malcolm G. Munro, with Timothy C. Rowe. 332 pp., illustrated. Baltimore, Williams and Wilkins, 1990. $29.95.
Authors: David H. Nichols
Journal: New England Journal of Medicine (1991)
Can Breast Cancer Be Avoided? Researchers Give Their Input
Authors: J. Ziegler
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Can Breast Cancer Be Avoided? Researchers Give Their Input Get access Jan Ziegler Jan Ziegler Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 18, 21 September 1994, Pages 1374–1375, https://doi.org/10.1093/jnci/86.18.1374 Published: 21 September 1994
Targeting TLRs Expands the Antibody Repertoire in Response to a Malaria Vaccine
Authors: Steven R. Wiley, Vanitha S. Raman, Anthony Desbien, Hilton R. Bailor, Rukmini Bhardwaj, Ahmed Rushdi Shakri, Steven G. Reed, Chetan E. Chitnis, Darrick Carter
Journal: Science Translational Medicine (2011)

The use of TLR agonists in vaccination broadens the range of polymorphic variants against which the antibodies can be effective.
Spontaneous Recovery of Reduced Cortical Central Benzodiazepine Receptor Binding Potential on I-123 Iomazenil SPECT in a Patient With Status Epilepticus
Authors: Hiroki Kuroda, Kuniaki Ogasawara, Kenta Aso, Takaaki Beppu, Masakazu Kobayashi, Kohei Chida, Akira Ogawa
Journal: Clinical Nuclear Medicine (2010)

A reduction in cortical benzodiazepine receptor binding potential on late images of I-123 iomazenil SPECT indicates irreversible neural damage or loss. We present the case of a 26-year-old woman with status epilepticus in whom SPECT imaging using I-123 iomazenil and I-123 N-isopropyl-p-iodoamphetamine 7 and 9 days after the last seizure, respectively, demonstrated reduction in central benzodiazepine receptor binding potential with hyperperfusion in the affected cerebral hemisphere and crossed cerebellar hypoperfusion. However, 3 months later, repeat studies showed resolution of the reduction in cortical benzodiazepine receptor binding potential, resolution of hyperperfusion, and resolution of crossed cerebellar hypoperfusion.
Scintigraphic Findings Mimicking Focal Nodular Hyperplasia in a Case of Hepatoblastoma
Authors: DOINA E. TANASESCU, ALAN D. WAXMAN, CAROLE HURVITZ
Journal: Clinical Nuclear Medicine (1991)

Hepatoblastoma is a primary liver neoplasm in which prompt diagnosis and resection are critical to long-term survival. Liver scintigraphy using Tc-99m sulfur colloid and Tc-99m iminodiacetic acid (IDA) derivatives has been used in the evaluation of hepatic masses. Most space-occupying lesions of the liver appear as photopenic regions following either Tc-99m SC or IDA agents. Two exceptions have been reported. Focal nodular hyperplasia (FNH) has been shown to have variable colloid uptake, which is dependent upon the number of Kupffer cells per given volume. Many patients with FNH will demonstrate activity within the FNH to be greater or equal to the normal liver. In addition, two cases of hepatoblastoma have been reported to show colloid activity within the tumor, and in one patient slight uptake of Tc-99m IDA was noted in the tumor 15 minutes postinjection. The current case demonstrates a hepatoblastoma in which the scintigraphic findings with Tc-99m SC and Tc-99m IDA were similar to those reported, with retention of IDA far greater than the previously reported case.
Management of TIAs
Authors: Jerry J. Svoboda
Journal: JAMA (1985)

To the Editor.—  We write to express a difference of opinion with the answer given by Dr David Lefkowitz 1 in the QUESTIONS AND ANSWERS section regarding investigation and management of focal transient ischemic attacks (TIAs). Dr Lefkowitz stated that noninvasive carotid studies  obviate the need for contrast studies in selected  and that  is indicated when the patient has clinical or noninvasive evidence of significant extracranial atherosclerosis without contraindications to surgery.  Although noninvasive carotid studies may eliminate the need for angiography in some patients, the case question concerned a patient with a focal TIA. We feel that patients with focal TIAs require angiography and a cerebral computed tomographic (CT) scan for diagnosis if they are operative candidates. If preangiographic noninvasive studies demonstrate severe carotid stenosis, intravenous digital-subtraction angiography will usually be adequate to confirm this. If noninvasive studies show lesser degress of stenosis or are normal for
Delayed onset of skin fibrosis after the ingestion of eosinophilia-myalgia syndrome-associated l-tryptophan
Authors: Adam S Greenberg, Hajime Takagi, Robert H Hill, Anthony Hasan, Hiroshi Murata, Vincent Falanga
Journal: Journal of the American Academy of Dermatology (1996)

pression may favor the development of this tumor, as happens with other mesenchymal proliferations.This view is upheld by the fact that the tumor ceased recurring after the immunosuppressive treatment had been reduced.
General practitioners' response to a postal questionnaire survey.
Authors: M White
Journal: BMJ (1991)

sawtooth pattern might be expected, with low diagnostic accuracy in February and March and in August and September, rising (with a little "noise" from locum cover) towards a peak when doctors were trained.No training effect is seen-at least, none that is clinically useful.It is not credible that the package used in Bangour resulted in junior doctors being trained within the first month of their contract, though that is possible for Mr de Dombal and colleagues' system.One explanation of these results is that where a computer system stimulates consultants' interest in junior doctors' training a useful gain is seen, but where the computer system comes to be a subsitute for that the learning curve remains flat.
Relation between clinical features of the mitral prolapse syndrome and echocardiographically documented mitral valve prolapse
Authors: Richard B. Devereux, Randi Kramer-Fox, W. Ted Brown, M. Katherine Shear, Neil Hartman, Paul Kligfield, Elizabeth M. Lutas, Mariane C. Spitzer, Stephen D. Litwin
Journal: Journal of the American College of Cardiology (1986)
Impairment of Polymorphonuclear Leukocyte Function and Metabolic Control of Diabetes
Authors: Wilhelm Marhoffer, Michael Stein, Erika Maeser, Konrad Federlin
Journal: Diabetes Care (1992)

In this study, ingestion of Staphylococcus aureus and "bacteria killing" (BK) were measured to evaluate polymorphonuclear leukocyte (PMN) phagocytic functions and chemiluminescence response (CL) to phorbol-myristic acetate (PMA) as respiratory burst activity with regard to metabolic control parameters in diabetic patients.PMN phagocytic functions were assessed in 40 diabetic patients, all receiving insulin and in poor metabolic control, with 3H-thymidine-labeled Staphylococcus aureus in a modified radiometric assay. Bacteria killing was determined by pure-plate counting of surviving bacteria (colony-forming units [cfu]) and luminol-enhanced CL in response to PMA as a measure of respiratory burst. PMN function data were correlated to HbA1 as parameter of recent metabolic control.PMN of diabetic patients showed a significant reduction in Staphylococcus aureus (50.7 +/- 4.1%) and BK (29.4 +/- 4.2%) compared with healthy nondiabetic control subjects (76.6 +/- 4.6% and 16.3 +/- 3.1%, respectively, P less than 0.001), and PMN CL response was markedly reduced in diabetic patients also. Linear regression analysis showed a highly significant negative correlation of HbA1 versus Staphylococcus aureus (r = -0.67, P = 0.001) and a positive correlation for BK (r = 0.73, P less than 0.001). This was also true for CL, although this did not reach statistical significance (P = 0.06).The data obtained demonstrate impaired PMN phagocytic functions and CL response in diabetic patients. These findings suggest inhibitory effects of elevated glucose concentrations on PMNs, a possible role of protein glycosylation for impairing PMN function, thus contributing in part to altered host defense.
609 Activated STAT3 initiates antiviral activity against hepatitis C viral RNA replication
Authors: H ZHU, Z SHANG, N TERADA, J CRAWFORD, C LIU
Journal: Hepatology (2003)

We previously showed that a fish interferon (IFN) regulatory factor 9 (IRF9) homologue, crucian carp Carassius auratus IRF9, displays constitutively nuclear localization and involvement in fish IFN-dependent JAK-STAT signaling; however, little is known about the expression regulation of fish IRF9. Here, we characterized the expression of zebrafish IRF9 by promoter analysis. Zebrafish IRF9 gene promoter contained several putative transcription factor binding sites, including one ISRE (IFN-stimulated response element), one GAS (IFN gamma activation sequence) and three GATEs (IFNγ activated transcriptional element, GATE1/2/3). Further sequence analyses revealed that GAS and GATE motifs existed in all promoters of IRF9 from mammals and fishes. Luciferase assays confirmed that zebrafish IRF9 promoter could be activated by zebrafish IFNφs and zebrafish IFNγ2, as well as transcription factors IRF3, IRF7, and combination of IRF9 and STAT2. Treatment of recombinant crucian carp IFN protein or overexpression of zebrafish IFNγ2 both led to significant increase in crucian carp IRF9 mRNA and protein in cultured fish cells. Comparison of IFN-stimulated promoter activity revealed much more significant induction of zebrafish IRF9 by zebrafish IFNγ2 than by zebrafish IFNφs. Mutation analyses showed that the putative GAS and GATE3 contributed to zebrafish IFNγ2-triggered IRF9 expression, whereas the putative ISRE and the other two GATEs were not functional for induction of zebrafish IRF9. These results together indicated that the expression property of IRF9 might be conserved from fish to mammals and that some not yet identified mechanisms could exist in IRF9 gene transcription regulation in response to IFNs.
The Human Alzheimer Disease Project
Authors: Roger N. Rosenberg, Ronald C. Petersen
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Length of menstrual cycle.
Authors: H. J. Cox
Journal: BMJ (1968)

BDIC^Lvesicles on the body.In the next few days there was further improvement.From thirteen days on, palms and soles desquamated in large flakes.On the sixteenth day the mouth had healed, with residual brown spots on lips.Skin of soles peeled off like sandals, in one piece.The patient was admitted to a general ward and treatment was symptomatic.On discharge the patient was warned that for some time he might spread foot-and-mouth disease among animals, and that therefore he should avoid contact with susceptible animals.Veterinary authorities were notified about this patient and carried out inspections in the district in which the slaughterhouse was situated.Foot-and-mouth disease was found among animals, although previously this district was declared free from disease.In conclusion I would like to emphasize that the health authorities would be well advised to pay close attention to the possibility of the disease in man as a potential factor in the spread of foot-and-mouth disease.-Iam, etc., London W. 13.