tbuckley/cabot-search huggingface dataset:
Action of Lobeline on Pulmonary Artery Mechanoreceptors of the Cat
Authors: JOHN A. BEVAN, GERALD L. KINNISON
Journal: Circulation Research (1965)

1. The effects of lobeline (15 to 45 µg/kg) and of local changes of pulmonary artery pressure on the afferent activity of single neurone preparations of pulmonary artery mechanoreceptors have been studied in the intact cat. Pulmonary artery pressure was monitored via a double lumen balloon catheter passed into the pulmonary artery. 2. Pulmonary artery mechanoreceptors were distinguished from systemic mechanoreceptors by applying two simple tests to all mechanoreceptors found by random selection of single fibers from the right cervical vagus. The afferent activity of pulmonary mechanoreceptors closely followed induced changes of pulmonary artery pressure, whereas other arterial mechanoreceptors did not. Pulmonary artery pressure was increased by the rapid injection of 2 ml dextran into the right atrium and was reduced by inflation of the intravascular balloon. 3. In the absence of a rise in pulmonary artery pressure, lobeline increased the afferent activity in two phases. The early response, which was seen in 17 of the 18 fibers studied, occurred within one to two seconds after injection and was characteristically a variable and moderate response. This effect is caused probably by the diffusion of lobeline to sensory endings within the pulmonary artery wall. The delayed response occurred about eight to ten seconds later. The activity of afferent fibers was intensified conspicuously and frequencies up to 300/sec were recorded. It is probable that this is due to the action of lobeline carried by the vasa vasorum to the intramural receptors. 4. By combining the results following balloon inflation and dextran injection, the relationship between impulses per heart beat and mean pulmonary artery pressure was established for a number of pulmonary artery mechanoreceptors in the intact animal. 5. Pulmonary artery mechanoreceptors were insensitive to doses of veratridine and relatively insensitive to doses of phenyldiguanide which, in the intact cat, produce equivalent reflexogenic responses as lobeline (45 µg/kg). 6. Other intrathoracic sensory endings studied, including atrial and ventricular stretch receptors, Hering-Breuer receptors, and systemic mechanoreceptors, were completely insensitive to the doses of lobeline used in these experiments. 7. These results support earlier experiments which suggested that when lobeline is injected, its reflex effect from the pulmonary vascular bed, namely depression of ventilation, is due to its action on a pressure- or stretch-sensitive area in the region of the bifurcation of the pulmonary artery.
The Effects on Rabbits of Immunization with Bovine Thyroid-Stimulating Hormone and its Subunits
Authors: Gildon N. Beall, Inder J. Chopra, David H. Solomon, John G. Pierce, James S. Cornell
Journal: Journal of Clinical Investigation (1973)

Rabbits were immunized with bovine thyroid-stimulating hormone (bTSH), bovine Inteinizing hormone (bLH), and their subunits. In two immunization experiments, thyroid-stimulating activity was found in the serum of 6 out of 12 rabbits immunized with bTSHbeta subunits. The thyroid-stimulating activity in the anti-bTSHbeta sera was greater at 2 h than at 8, was eluted with the globulin fraction from Sephadex G-100, was completely neutralized by both anti-bTSH and anti-rabbit gamma globulin, and was completely suppressed by administration of triiodothyronine (T(3)) to the immunized rabbit. These findings led to the conclusion that the thyroid-stimulating activity resided in soluble complexes of rabbit TSH bound to anti-bTSHbeta. Two of nine rabbits immunized with bTSH developed thyroid-stimulating activity in their serum, but it was nonsuppressible by T(3). None of the animals immunized with bTSHalpha, bLH, bLHbeta, or bLHalpha developed serum thyroid-stimulating activity.Hypopituitary hypothyroidism, evidenced by decreased serum thyroxine (T(4)) and thyroidal (131)I uptake and by the histologic appearance of large follicles with flat cells, was found in the bTSHbeta- and bTSH-immunized animals, despite the presence of thyroid-stimulating activity in the serum of many. The reasons for this paradox are unclear; possibly the complexes block the effect of TSH on the rabbit thyroid.
Measuring disease activity and damage in discoid lupus erythematosus
Authors: S. Wahie, E. McColl, N.J. Reynolds, S.J. Meggitt
Journal: British Journal of Dermatology (2010)

Discoid lupus erythematosus (DLE) is a disfiguring inflammatory skin disease. There is no specific tool for measuring disease severity.To determine the features needed in a score measuring activity and damage in DLE and to investigate the score's reliability and its correlation with the physician's global assessment of disease severity and the patient-reported Dermatology Quality of Life Index (DLQI).The content of the score was determined following a peer review, pilot work in patients and a preliminary inter-rater reliability study. The Score of Activity and Damage in DLE (SADDLE) measures severity of activity (erythema, scale, induration) and damage (scarring/atrophy and dyspigmentation) attributable to DLE. Summed scores range between 0 and 195. Inter- and intrarater reliability of the score was tested using six assessors and nine patients with DLE. Intraclass correlation coefficients (ICCs) > 0.7 were considered evidence of good inter- and intrarater agreement.The mean +/- SD SADDLE score of nine patients in the inter-rater reliability study was 47 +/- 22 (range 14-102). There was good inter-rater agreement for the total score [ICC 0.82; 95% confidence interval (CI) 0.61-0.95] and for the activity and damage scales, the individual physical signs and the total scores at individual body sites. The total score demonstrated excellent intrarater reliability (ICC 0.98; 95% CI 0.86-1.00). Although there was poor inter-rater agreement for global assessments (ICC 0.28; 95% CI 0.06-0.66), a good correlation was demonstrated between total scores and global assessments (r = 0.7). A weaker positive correlation was observed between disease activity scores and DLQI (r = 0.4).The SADDLE measures activity and damage in patients with DLE. It demonstrates good inter- and excellent intrarater agreement, over and above that for global assessment. It correlates well with global assessment scores. Further studies are required to investigate SADDLE's responsiveness to change with therapy.
Response of Hemiballismus to Haloperidol
Authors: Gordon J. Gilbert
Journal: JAMA (1975)

THE CONTINUOUS involuntary flailing movements of hemiballismus have proved resistant to medical therapy. In 1959, Martin and McCaul1described effective surgical treatment by placement of a stereotactic lesion in the thalamic ventrolateral nucleus. Recently, Pearce2has reported from England the successful treatment of a case of hemiballismus with the drug tetrabenazine (Nitoman; available only in Britain). Neither tetrabenazine nor any comparable product is available in the United States. In certain cases of hemiballismus, the movement disorder will gradually subside spontaneously,3but in many others it is unremitting and may be life-threatening to the elderly patient with limited cardiac reserve. In the case presently reported, treatment with haloperidol (Haldol) produced a prompt, marked, and sustained improvement in hemiballismus.  Report of a Case  A 79-year-old diabetic man had hemiballismus of the right extremities of three weeks' duration, which had markedly worsened over the ten days prior to admission. For several
Cervicitis in College Students
Authors: Winstom Summerlin
Journal: JAMA (1985)

To the Editor.—  A rigid routine of my gynecology practice for the past 25 years involved colposcopy for every patient on a yearly basis. As long as I was in private practice, with a diverse age group, there were no startling patterns discernible from this procedure. A few months ago, however, I moved to a Student Health Service as gynecologist for more than 10,000 female students. It was immediately obvious that a serious problem existed in regard to cervicitis—specifically condyloma acuminatum of the cervix.  There were 742 college co-eds evaluated on routine visits to the gynecology (and contraceptive) clinic. A green filter at X16 magnification demonstrated these changes much better than a red filter at X8 magnification.  The patients were divided into three clinical groups: (1) no cervical lesions, 226; (2) eversion—less than 1 cm, 127; and (3) eversion—greater than 1 cm, 77, or punctation, mosaic, flat condyloma, 312 (many
Induction of ΔFosB in the Periaqueductal Gray by Stress Promotes Active Coping Responses
Authors: Olivier Berton, Herbert E. Covington, Karl Ebner, Nadia M. Tsankova, Tiffany L. Carle, Paula Ulery, Akshay Bhonsle, Michel Barrot, Vaishnav Krishnan, Georg M. Singewald, Nicolas Singewald, Shari Birnbaum, Rachael L. Neve, Eric J. Nestler
Journal: Neuron (2007)
CD28 co-stimulation induced Lck signaling is important for survival and antigen-specific functionality of re-directed T cells
Authors: Pratiksha Gulati, Petra Schuberth, Christoph Renner, Christian Munz, Ulf Petrausch
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Adoptive transfer of re-directed T cells which are engineered to express receptors that target tumor-associated molecules and signal T cell effector functions has emerged as an effective therapeutic approach for cancer. Chimeric antigen receptors (CARs) are recombinant receptors
Methotrexate inhibits polymorphonuclear leucocyte chemotaxis in psoriasis
Authors: U. WALSDORFER, E. CHRISTOPHERS, J.-M. SCHRODER
Journal: British Journal of Dermatology (1983)

Journal Article Methotrexate inhibits polymorphonuclear leucocyte chemotaxis in psoriasis Get access U. WALSDORFER, U. WALSDORFER Department of Dermatology, University of Kiel, Kiel, West Germany Search for other works by this author on: Oxford Academic Google Scholar E. CHRISTOPHERS, E. CHRISTOPHERS Department of Dermatology, University of Kiel, Kiel, West Germany Search for other works by this author on: Oxford Academic Google Scholar J.‐M. SCHRÖDER J.‐M. SCHRÖDER Department of Dermatology, University of Kiel, Kiel, West Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 108, Issue 4, 1 April 1983, Pages 451–456, https://doi.org/10.1111/j.1365-2133.1983.tb04598.x Published: 01 April 1983 Article history Accepted: 16 August 1982 Published: 01 April 1983
Aging effects on DNA methylation modules in human brain and blood tissue
Authors: Steve Horvath, Yafeng Zhang, Peter Langfelder, René S Kahn, Marco PM Boks, Kristel van Eijk, Leonard H van den Berg, Roel A Ophoff
Journal: Genome biology (2012)

Several recent studies reported aging effects on DNA methylation levels of individual CpG dinucleotides. But it is not yet known whether aging-related consensus modules, in the form of clusters of correlated CpG markers, can be found that are present in multiple human tissues. Such a module could facilitate the understanding of aging effects on multiple tissues.We therefore employed weighted correlation network analysis of 2,442 Illumina DNA methylation arrays from brain and blood tissues, which enabled the identification of an age-related co-methylation module. Module preservation analysis confirmed that this module can also be found in diverse independent data sets. Biological evaluation showed that module membership is associated with Polycomb group target occupancy counts, CpG island status and autosomal chromosome location. Functional enrichment analysis revealed that the aging-related consensus module comprises genes that are involved in nervous system development, neuron differentiation and neurogenesis, and that it contains promoter CpGs of genes known to be down-regulated in early Alzheimer's disease. A comparison with a standard, non-module based meta-analysis revealed that selecting CpGs based on module membership leads to significantly increased gene ontology enrichment, thus demonstrating that studying aging effects via consensus network analysis enhances the biological insights gained.Overall, our analysis revealed a robustly defined age-related co-methylation module that is present in multiple human tissues, including blood and brain. We conclude that blood is a promising surrogate for brain tissue when studying the effects of age on DNA methylation profiles.
IL-28B rs12979860 C/T allele distribution in patients with liver cirrhosis: Role in the course of chronic viral hepatitis and the development of HCC
Authors: Carlo Fabris, Edmondo Falleti, Annarosa Cussigh, Davide Bitetto, Elisabetta Fontanini, Sara Bignulin, Sara Cmet, Ezio Fornasiere, Elisa Fumolo, Stefano Fangazio, Andrea Cerutti, Rosalba Minisini, Mario Pirisi, Pierluigi Toniutto
Journal: Journal of Hepatology (2010)
Wernicke's Syndrome: What We Don't Teach
Authors: Katherine Mulloy
Journal: JAMA (1987)

<h3>To the Editor.—</h3> It has been recognized that Wernicke's encephalopathy is significantly underdiagnosed during life.<sup>1-4</sup>Many physicians learn to look for this disorder only in patients with chronic alcoholism.<sup>4</sup>Reuler et al<sup>3</sup>note this syndrome is "even less frequently considered in the nonalcoholic population." We have noted that Wernicke's encephalopathy is infrequently considered when a history of alcoholism is absent, despite malnutrition. <h3>Study.—</h3> We evaluated our medical and neurological house staff's knowledge of Wernicke's encephalopathy by reading a vignette to 40 consecutive residents doing a rotation on the neurology service between May 1986 and May 1987. The following vignette was read to each resident: "You are a physician in the emergency room and you are asked to see a 63-year-old woman with a history of stomach cancer who is brought to the ER because of confusion. She is not able to really give you much more history.
A neurobiological strategy for exploring links between emotion recognition in music and speech
Authors: Aniruddh D. Patel
Journal: Behavioral and Brain Sciences (2008)

Abstract Are the neural systems involved in recognizing affective prosody in language also used for emotion recognition in instrumental music? One way to test this idea is to study musical affect perception in patients with receptive affective aprosodia (RAA). Music perception in RAA is totally unexplored and could provide a powerful way to test the idea that we perceive music as a kind of emotional voice.
CONTACT DEEMATITIS XVII
Authors: Etain Cronin
Journal: British Journal of Dermatology (1972)

Journal Article CONTACT DEEMATITIS XVII Get access Etain Cronin Etain Cronin St John's Hospital London W.C.2 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 86, Issue 1, 1 January 1972, Pages 104–107, https://doi.org/10.1111/j.1365-2133.1972.tb01907.x Published: 01 January 1972
Phase II Study of Bevacizumab Plus CBDCA/PAC as First Line Chemotherapy for Non-SQ NSCLC with Malignant Pleural Effusion
Authors: M. Tamiya, A. Tamiya, T. Yasue, H. Suzuki, N. Okamoto, K. Okishio, K. Asami, T. Kawaguchi, S. Atagi, T. Hirashima
Journal: Annals of Oncology (2013)
British-Polish workshops on substance misuse services.
Authors: K. Checinski
Journal: BMJ (1992)

to them to set up strong audit structures in their units (£42 1 million in 1992-3)' they have only themselves to blame for a remarkable lack of initiative.But then effective audit requires not only hard work but also the active participation and commitment of senior doctors.On the other hand, picking up the telephone and complaining to the press is so much simpler and avoids the rather tedious business of systematic and critical analysis.For all that, it is time that we recognised and used the right whistle.
The effect of long-term treatment with spironolactone on variceal pressure in patients with portal hypertension without ascites
Authors: F Nevens
Journal: Hepatology (1996)

The effect of spironolactone on esophageal variceal pressure (VP) in patients without ascites was investigated. VP was assessed using a noninvasive endoscopic gauge. Spironolactone was administered during a 6-week period at a dosage of 100 mg/d. This treatment decreased VP from 16.8 +/- 1.9 (SD) to 14.1 +/- 2.7 mm Hg (P < .001) in a group of 12 patients and from 18.6 +/- 2.1 to 13.7 +/- 4.1 mm Hg (P < .01) in another group of 8 patients who still had high VP despite chronic intake of propranolol. In both groups, placebo administration to 12 and 8 comparable patients did not significantly alter VP. Spironolactone induced a significant reduction of plasma volume (42.1 +/- 5.5 to 36.1 +/- 6.6 mL/kg body weight, P < .01) and of the concentration of alpha-atrial natriuretic peptide (alpha-ANP) (39.8 +/- 22 to 27.7 +/- 20 pg/mL, P < .01); in addition, a pronounced increase in plasma renin activity (PRA) (1.1 +/- 0.9 to 7.5 +/- 3.4 ng/mL/h, P < .001) was induced by the treatment. No significant changes in systemic hemodynamics were observed during the studies. Severe side effects were not observed except for a high incidence (55%) of painful gynecomasty in the male patients. In conclusion, chronic spironolactone administration effectively lowers VP, even in patients under chronic propranolol therapy. The combination of propranolol and spironolactone deserves further study as a prophylactic therapy of variceal hemorrhage, but development of gynecomasty might be a problem. Finally, we confirmed the reproducibility of VP measurements with the noninvasive gauge in chronic conditions.
Causes of Sudden Deterioration During Pulmonary Intensive Care.
Authors: Kenneth M. Moser
Journal: Annals of Internal Medicine (1967)

s1 May 1967Causes of Sudden Deterioration During Pulmonary Intensive Care.Kenneth M. Moser, M.D., F.A.C.P., P. Gregg Rhodes, M.D.Kenneth M. Moser, M.D., F.A.C.P.Search for more papers by this author, P. Gregg Rhodes, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1056_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 52 patients requiring pulmonary intensive care (PIC), including intubation and assisted ventilation, the acute complications producing sudden clinical deterioration were analyzed. Most had distinctive diagnostic features and were reversible if recognized promptly.The five leading complications were [1]occlusion of main-stem bronchus by tube(6 patients). The endotracheal or long tracheostomy tube usually enters the right main-stem bronchus, occluding the left. Diagnostic features include sudden dyspnea, dullness and decreased breath sounds over the left hemithorax, leftward mediastinal shift, left lung opacification by X ray, and prompt response to tube repositioning; [2]cardiac arrhythmias(11 patients). Varied arrhythmias are so... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1967Volume 66, Issue 5Page: 1056-1056KeywordsArrhythmiaDyspneaIntubationLungsPatientsTracheostomy Issue Published: 1 May 1967 PDF DownloadLoading ...
Intra-arterial stenting in the atherosclerotic rabbit.
Authors: K A Robinson, G S Roubin, R J Siegel, A J Black, R P Apkarian, S B King
Journal: Circulation (1988)

The major problem associated with percutaneous transluminal coronary angioplasty is recurrence of the stenotic lesion. Balloon catheter-mounted intracoronary stent devices may reduce restenosis by improving luminal morphology and flow characteristics. This study assessed the effects of a stainless steel wire, interdigitating coil stent on restenosis in the atherosclerotic rabbit model. Fifteen cholesterol-fed rabbits with preexisting iliac arterial lesions induced by balloon deendothelialization were instrumented in one iliac artery with a 2.0-mm diameter stent after balloon dilatation; the contralateral iliac lesion was treated by dilatation only to serve as a control. The animals were given heparin with aspirin (60 mg) and aspirin every 3rd day until death. Arteriography was repeated 4 weeks after stenting, just before death. Tissue sections from stented and control arterial segments were analyzed morphometrically. Stented arteries had a significantly larger luminal diameter at restudy, whether measured by arteriography (1.38 +/- 0.19 vs. 0.94 +/- 0.35 mm, p less than 0.01) or from tissue sections (1.26 +/- 0.18 vs. 0.81 +/- 0.30 mm, p = 0.0001). Wall thickness of the stented segment was slightly, but significantly, less than the control segment (436 +/- 143 vs. 532 +/- 221 microns, p less than 0.05). Scanning electron microscopy of five stented atherosclerotic rabbit aortas revealed regeneration of a nonthrombogenic, confluent, flow-directed endothelium by 4 weeks after placement. Intra-arterial stenting may be of benefit in the prevention of restenosis by the preservation of a larger functional lumen and by a decrease in the neointimal hyperplastic response to arterial injury.
AN OUTLINE FOR THE PSYCHIATRIC CLASSIFICATION OF PROBLEM CHILDREN. By <i>Sanger Brown, II, M. D.,</i> Assistant Commissioner of Mental Hygiene, <i>Horatio M. Pollock, Ph. D.,</i> Director of Mental Health Statistics, and <i>Howard W. Potter, M. D.,</i> Assistant Director, Psychiatric Institute and Hospital. (Utica, New York: State Hospitals Press, 1933.)
Authors: E. P. Lewis
Journal: American Journal of Psychiatry (1934)
Defective expression of the 2H4 molecule after autologous mixed lymphocyte reaction activation in systemic lupus erythematosus patients.
Authors: T Takeuchi, S Tanaka, A D Steinberg, T Matsuyama, J Daley, S F Schlossman, C Morimoto
Journal: Journal of Clinical Investigation (1988)

Previous studies demonstrated that patients with active systemic lupus erythematosus (SLE), especially those with active renal disease, had a marked reduction in T4+2H4+ suppressor inducer cells in their peripheral blood. However, it was puzzling to find that active SLE patients without renal diseases often had normal percentages of T4+2H4+ cells. In the present study, we attempted to determine whether active SLE patients bearing normal percentages of T4+2H4+ cells had a defect in their expression of the 2H4 molecule on T4+ cells after autologous mixed lymphocyte reaction (AMLR) activation. The peripheral blood lymphocytes (PBL) from 50 SLE patients with normal percentages of T4+2H4+ cells (greater than or equal to 7% in PBL) were studied and the results were compared with those of 40 normal individuals. The density of the 2H4 molecule on T4 cells from normal controls increased during the 7-d AMLR; in contrast T4 cells from patients with SLE, especially those with active SLE, had defective expression of the 2H4 antigen after AMLR activation. Patients with inactive SLE, like normals, showed an increase in the 2H4 molecule after AMLR activation. Moreover, a strong correlation was observed between percent suppression of pokeweed mitogen (PWM)-driven IgG synthesis and the density of the 2H4 antigen on AMLR-activated T4 cells. Serial analysis of patients with SLE showed that the density of the 2H4 antigen expression and the suppressor inducer activity of AMLR-activated T4 cells were inversely correlated with disease activity. Thus, defective expression of the 2H4 antigen may be an important mechanism for the failure of active SLE patients with normal percentages of T4+2H4+ cells to generate suppression.
Having a higher blast percentage in circulation than bone marrow: clinical implications in myelodysplastic syndrome and acute lymphoid and myeloid leukemias
Authors: H M Amin, Y Yang, Y Shen, E H Estey, F J Giles, S A Pierce, H M Kantarjian, S M O'Brien, I Jilani, M Albitar
Journal: Leukemia (2005)