tbuckley/cabot-search huggingface dataset:
Inhibition of Pim1 kinase prevents peanut allergy by enhancing Runx3 expression and suppressing TH2 and TH17 T-cell differentiation
Authors: Meiqin Wang, Masakazu Okamoto, Joanne Domenico, Junyan Han, Shigeru Ashino, Yoo Seob Shin, Erwin W. Gelfand
Journal: Journal of Allergy and Clinical Immunology (2012)
Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper
Authors: Matthias G. Friedrich, Udo Sechtem, Jeanette Schulz-Menger, Godtfred Holmvang, Pauline Alakija, Leslie T. Cooper, James A. White, Hassan Abdel-Aty, Matthias Gutberlet, Sanjay Prasad, Anthony Aletras, Jean-Pierre Laissy, Ian Paterson, Neil G. Filipchuk, Andreas Kumar, Matthias Pauschinger, Peter Liu
Journal: Journal of the American College of Cardiology (2009)
High powered inquiry into Bristol deaths
Authors: J. Warden
Journal: BMJ (1998)

Stricter monitoring of surgical performance in Britain is expected to result from a public inquiry into the deaths of 29 babies and young children who died after heart surgery in Bristol.

The inquiry was announced in parliament by the health secretary, Frank Dobson, immediately after the General Medical Council's decision. He later criticised the GMC for striking off the register only two of the three doctors accused.

The inquiry will be conducted by the leading expert in medicolegal issues, Professor Ian Kennedy of University College, London. He is on the BMA's medical ethics committee and was a lay member of …
Evidence that granulocyte macrophage-colony-stimulating factor regulates the distribution and differentiated state of dendritic cells/Langerhans cells in human lung and lung cancers.
Authors: A Tazi, F Bouchonnet, M Grandsaigne, L Boumsell, A J Hance, P Soler
Journal: Journal of Clinical Investigation (1993)

GM-CSF has been shown to be important for the survival and function of cells of dendritic cell/Langerhans cell (LC) lineage in vitro. Since these cells have been demonstrated to infiltrate human lung and some lung carcinomas, we hypothesized that the production of GM-CSF in the lung could be important in their recruitment and differentiation. Using both immunohistochemistry and in situ hybridization, we have shown that: (a) GM-CSF was produced by normal bronchiolar epithelium, the only site were CD1a+ LC are observed in the normal lung, whereas neither GM-CSF production nor LC were identified in normal alveolar epithelium. (b) In inflamed pulmonary tissue, hyperplastic alveolar cells produced GM-CSF, and CD1a+ LC accumulated adjacent to these cells. (c) Some, but not all, lung carcinomas produced this cytokine, and a close correlation was found between the production of GM-CSF and the number of CD1a+ LC infiltrating these tumors. Since GM-CSF was produced at all sites where CD1a+ LC are known to accumulate, but not at other locations within the lung, these data suggest that the local production of GM-CSF by certain lung cells may play an important role in determining the distribution and differentiated state of dendritic cell/LC in the human lung.
Inhibition of xanthine oxidase by allopurinol: its lack of effect on models of inflammation.
Authors: R E Allen, A W Claxson, D R Blake, C J Morris
Journal: Annals of the Rheumatic Diseases (1990)

Leucopenia after gold and sulphasalazine treatment Sir: I read the interesting report by Bliddal and colleagues of three patients who developed leucopenia after both gold and sulphasalazine treatment.'HLA-DR3 as a marker for toxic reactions after treatment with gold or D- penicillamine could not be shown.Patient 1, however, was apparently a carrier of HLA- B27.It is well known that female patients with rheumatoid arthritis, who are HLA-B27 posi- tive, have a significantly higher risk for drug induced agranulocytosis, not only after treat- ment with levamisole2 3 but also with other antirheumatic drugs.4Thus under these con- ditions the possibility should be considered that in this patient, in the absence of HLA- D3, HLA-B27 may be the risk indicator for her relapsing leucopenia.
Continued Zidovudine and Interferon-Alpha Therapy in Kaposi Sarcoma and the Acquired Immunodeficiency Syndrome (AIDS)
Authors: R. De Wit, P. J.M. Bakker, K. H.N. Veenhof, S. A. Danner
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 February 1990Continued Zidovudine and Interferon-Alpha Therapy in Kaposi Sarcoma and the Acquired Immunodeficiency Syndrome (AIDS)Ronald de Wit, MD, Piet J.M. Bakker, MD, Kees H.N. Veenhof, PhD, Sven A. Danner, PhDRonald de Wit, MDSearch for more papers by this author, Piet J.M. Bakker, MDSearch for more papers by this author, Kees H.N. Veenhof, PhDSearch for more papers by this author, Sven A. Danner, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-4-306 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Kovacs and colleagues (1) recently reported on combined treatment with interferon-alpha and zidovudine in patients with the acquired immunodeficiency syndrome (AIDS)-associated Kaposi sarcoma. In their discussion, the question was raised whether the interferon-alpha alone or the combination was responsible for the antitumor activity. As we have shown in our previous single-agent interferon-alpha study (2), all major responses that were induced by the initial daily interferon-alpha schedule further improved or became complete responses during the thrice weekly maintenance schedule. Because Kovacs and colleagues escalated interferon-alpha towards high-dose during the initial 2 weeks as well, they may have induced...References1. KovacsDeytonDavey JLR. Combined zidovudine and interferon-alpha therapy in patients with Kaposi sarcoma and the acquired immunodeficiency syndrome (AIDS). Ann Intern Med. 1989;111:280-7. LinkGoogle Scholar2. de WitSchattenkerkBoucherBakkerVeenhofDanner RJCPKS. Clinical and virological effects of high-dose recombinant interferon-alpha in disseminated AIDS-related Kaposi's sarcoma. Lancet. 1988;2:1214-7. CrossrefMedlineGoogle Scholar3. LarderDarbyRichman BGD. HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy. Science. 1989;243:1731-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Academic Medical Center Amsterdam the Netherlands PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTHE ROLE OF RADIATION THERAPY IN THE MANAGEMENT OF HIV-RELATED KAPOSI'S SARCOMATreatment of Kaposi’s Sarcoma with Interferon-α and Other Biological Response ModifiersThe Potential Role of Cytokines in the Treatment of Viral InfectionsAre There Still Indications for Single Agent High-Dose Interferon-Alpha against AIDS-Associated Kaposi's Sarcoma? 15 February 1990Volume 112, Issue 4Page: 306-307KeywordsAIDSKaposi sarcoma Issue Published: 15 February 1990 PDF DownloadLoading ...
Bias in clinical trials
Authors: P. Sedgwick
Journal: BMJ (2011)

<h3>Objectives</h3> To assess the safety and effectiveness of administering local steroid injections in an operational field hospital environment. <h3>Method</h3> A prospective study of patients presenting to the physiotherapy department at the British Military Hospital (BMH) Shaibah, Iraq was undertaken from July 2006 – September 2006. Patients with a condition amenable to local steroid injection and who had not improved with conservative therapy were considered for the study. They then underwent local injection with steroid and local anaesthetic. <h3>Results</h3> During this period 12 patients were identified that fitted the criteria for local steroid injection. This represented 7% (12/179) of patients who were seen by the physiotherapy department in either an in or out-patient setting. All patients were injected with local anaesthetic and steroid injection with a single dose of intravenous antibiotic as antimicrobial cover. 10/12 (83.3%) were able to return to their unitwithin this theatre of operation. The only complication was one case of post injection flare of pain, which settled after 48 hours. <h3>Conclusion</h3> The use of local steroid injection, as an adjunct to physical therapy, can enable service personnel to remain in the theatre of operations. These patientsmay have otherwise required aero medical evacuation. We consider the use of a local steroid injection to be a safe and effective intervention in certain patients where conservative measures alone do not work. This study highlights the safety of using steroid injections in an operational field hospital setting. Further large scale studies may help corroborate this conclusion.
Physiological attributes of microbial BTEX degradation in oxygen-limited environments.
Authors: R H Olsen, M D Mikesell, J J Kukor, A M Byrne
Journal: Environmental Health Perspectives (1995)

Our work has focused on the determination of physiological traits that may facilitate in situ degradation of xenobiotic compounds by indigenous microorganisms. For this our interests center on the following questions: What are the ambient conditions in a benzene, toluene, ethylbenzene, and xylene (BTEX)-contaminated aquifer? What is the behavior of indigenous bacteria under these conditions? What are the attributes of bacterial strains that are functional under hypoxic conditions? How do these strains compare with other BTEX-degrading strains?
Long-Term Prognostic Value of 13N-Ammonia Myocardial Perfusion Positron Emission Tomography
Authors: Bernhard A. Herzog, Lars Husmann, Ines Valenta, Oliver Gaemperli, Patrick T. Siegrist, Fabian M. Tay, Nina Burkhard, Christophe A. Wyss, Philipp A. Kaufmann
Journal: Journal of the American College of Cardiology (2009)
Cooperative Study of Hospital Frequency and Character of Transient Ischemic Attacks
Authors: Thomas R. Price
Journal: JAMA (1977)

Examination during an episode of transient ischemic attack (TIA) was performed on 121 of 1,307 patients suspected of having a single type of TIA. This examination supported the diagnosis of TIA in 79 patients and contributed to the establishment of a diagnosis other than TIA in 42. Although the examination increased diagnostic reliability, it did not always result in a definite diagnosis. The most common neurologic findings during a TIA were weakness of an arm or side of the face. Important findings not suggested by history included visual defects and blood pressure fluctuation. Also unexpected were the absence of findings such as sensory deficits in the presence of sensory complaints, retinal emboli, and cardiac abnormalities. Severe arteriosclerotic disease was less evident, the attacks were longer and more severe, and monocular blindness was rare.
GSK lawyer accused of off-label promotion has case dismissed
Authors: J. H. Tanne
Journal: BMJ (2011)

The retired GlaxoSmithKline (GSK) lawyer Lauren Stevens was acquitted on 10 May of all counts related to alleged off-label marketing of bupropion for weight loss.

Judge Roger Titus of the US District Court in Greenbelt, Maryland, said in his ruling after the government had presented its case, “I believe it would be a miscarriage of justice to permit this case to go to the jury.”

Last year Ms Stevens was indicted as part of an investigation by the Food and Drug Administration into the off-label marketing of the antidepressant bupropion (which is marketed in the United States as Wellbutrin) for weight loss ( BMJ 2010;341:c6570, doi:10.1136/bmj.c6570). She was charged with …
Is measurement of girth of value in assessing intraperitoneal bleeding after trauma?
Authors: D F Finlayson, A G Muirhead
Journal: BMJ (1983)

He talked of his previous incarnation in eighteenth century Russia when he had led a large religious movement, was persecuted, and had castrated himself with a red-hot poker.There was no psychiatric history, but his father had died three days previously.A consultant psychiatrist diagnosed an acute reactive psychosis, detained the patient formally, and sedated him.He was then transfused, and his wounds were explored under general anaesthetic.There was a 10 cm scrotal laceration, and he had successfully excised the left testis and the lower pole of the right.Haemostasis was achieved and the wound debrided and sutured.He made a satisfactory recovery and was reviewed by the consultant psychiatrist, who found him to be lucid and rational.He was discharged on sedation with psychiatric and surgical follow up arranged but subsequently committed suicide by swallowing weedkiller.
German heart valve scandal escalates
Authors: H. L Karcher
Journal: BMJ (1996)

About 450 German hospitals and over 2700 doctors are now being investigated for accepting bribes from manufacturers of heart valves, life support equipment, cardiac pacemakers, and hip joints. These latest figures were released by Horst Rosenbaum, state attorney in the region of Wuppertal and North Rhine-Westphalia, in the continuing saga of the so called …
Alan Scott Falconer
Authors: A. F. C. T. P. Trewby
Journal: BMJ (2013)

Alan Scott Falconer was born in Darlington, the son of a GP-surgeon. His medical training was at Peterhouse College, Cambridge, and St George’s Hospital, London. He undertook house officer posts at St George’s, followed by national service in the Royal Navy. After obtaining his FRCS and surgical training at …
The Long-term Effects of Chlorpropamide on Insulin, C-Peptide, and Proinsulin Secretion
Authors: R S Elkeles, L G Heding, R B Paisey
Journal: Diabetes Care (1982)

It had been suggested that long-term lowering of blood glucose by sulfonylureas in non-insulin-dependent (NIDD) diabetes is not due to a sustained increase in insulin secretion. We have re-examined this question. Thirteen nonobese NIDD patients not controlled on diet alone were studied prospectively on treatment with chlorpropamide for over 3 mo. Of these, 9 were also studied after 1 yr. Improvement in glucose tolerance was associated with an increase in fasting and postglucose serum insulin and C-peptide concentration. We conclude that at least for over 1 yr chlorpropamide increases insulin secretion. After 3 and 12 mo the fasting proinsulin percentage of immunoreactive insulin was increased.
Persistent wheeze in grain elevator workers should not be ignored.
Authors: A Senthilselvan, P Pahwa, P Wang, H H McDuffie, J A Dosman
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

We investigated the relationship between annual change in pulmonary function and changes in respiratory symptoms among male grain elevator workers who participated in a health surveillance program mandated by Labour Canada. The surveillance was conducted every 3 yr starting from the period 1978 to 1981. The 1,211 workers who participated in the second (1981 to 1984) and fifth (1990 to 1993) surveillance were included in the analysis and the mean duration of the follow-up was 8.6 yr. In the analysis we also included the pulmonary function measurements that were available for some subjects at the third and fourth surveillance. The subjects who reported persistent wheeze had the largest mean annual rate change in FEV1 (-44.4 ml/yr) and FVC (-55.3 ml/yr). When adjusted for age, height, weight change, smoking, baseline lung function, location of grain elevators, and duration of employment, the subjects with persistent wheeze had an annual rate change of -28.3 ml/yr (SE 10.5; p = 0.007) in FEV1 and -37.3 ml/yr (SE = 12.3; p = 0.003) in FVC in comparison to subjects without any respiratory symptoms. The subjects who reported new onset of wheeze had significantly greater annual rate changes only in FEV1 (-13.7 ml/yr; SE 6.0; p = 0.02) in comparison to asymptomatic subjects' symptoms. Persistent wheeze is an important predictor of decline in lung function among grain elevator workers and should not be ignored in surveillance programs or clinical evaluations.
Abstract P2-07-03: High-throughput germline mutation screening for hereditary breast cancer in southern Chinese patients by massively parallel DNA sequencing
Authors: A Kwong, CH Au, FB Law, DN Ho, BK Ip, AT Wong, VY Shin, TL Chan, ES Ma
Journal: Cancer Research (2013)

Abstract Introduction: Breast cancer is the most common malignancy and 3rd leading cause of deaths among the female population in Hong Kong. Since the establishment of The Hong Kong Hereditary Breast Cancer Family Registry in 2007, 1344 patients with breast and/or ovarian cancer who met the selection criteria were recruited for genetic testing in Hong Kong. Since 2011 we started to employ next-generation DNA sequencing (NGS) to expedite the analysis workflow and expand the panel of genes for sequencing. Aim: To evaluate the workflow of NGS in mutation screening of BRCA1, BRCA2, TP53 and PTEN genes, and compared with the sequence data obtained by Sanger sequencing. Methods: We sequenced BRCA1, BRCA2, TP53 and PTEN genes in peripheral blood samples of 410 patients, 53 positive controls and 107 healthy local individuals using 454 GS Junior System. Generation of barcoded amplicon libraries was streamlined by microfluidic PCR using Fluidigm Access Array System. Sequencing data were analyzed by an in-house developed fully automatic bioinformatics pipeline, which mainly consists of GS Amplicon Variant Analyzer, SAMtools and Ensembl Variant Effect Predictor. All putative mutations identified were validated by Sanger sequencing. Furthermore, the frequency of BRCA1, BRCA2 and PTEN missense variants of unknown significance (VUS) identified in the cohort were compared among 107 healthy local individuals and 1000 Genomes project samples. The VUS were also subjected to a panel of in silico prediction methods including PolyPhen and SIFT. Results: Among 410 patients, there were 7 in BRCA1, 6 in BRCA2 and 1 in TP53 mutations found, including 1 novel recurrent BRCA2 (c.7007G&amp;gt;T) and 1 novel founder BRCA2 (c.5164_5165delAG) mutations. Based on multiple criteria, 12 in BRCA1, 12 in BRCA2 and 1 in PTEN VUS could be prioritized for further investigation. The bioinformatics pipeline was extensively evaluated with Sanger-validated controls. The evaluation determined minimum sequencing coverage needed in this sequencing platform for accurate analysis. The pipeline accuracy was demonstrated by successful detecting mutations from 53 positive controls, including single nucleotide variants, insertions and deletions in different sequence context. Conclusion: BRCA1, BRCA2, TP53 and PTEN mutation screening of 410 patients were expedited by high-throughput DNA sequencing. This method could detect 14 positive cases, including recurrent mutations, in a shorter period of time when compared with Sanger full gene sequencing. High-risk patients who are negative for the gene panel may need further investigation other than screening for BRCA1/2. The in-house developed bioinformatics pipeline was validated to detect various types of mutations and potentially become a conventional platform for genetic screening. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P2-07-03.
Production of paroxysmal nocturnal hemoglobinuria‐like red blood cells by tea
Authors: Lennette J. Benjamin, Bernard D. Goldstein, Ariel Distenfeld, Walter Troll
Journal: American Journal of Hematology (1977)

Abstract Normal human red cells incubated with saline extracts of tea develop paroxysmal nocturnal hemoglobinuria‐like defects as demonstrated by positive acid and sucrose hemolysis tests. All of a variety of tea preparations tested provoked a sensitivity to complement‐dependent hemolysis and, with one exception, a moderate decrease in red cell acetylcholinesterase activity. Complement‐dependent hemolysis in tea‐incubated red cells was inhibited by antisera to C3 and to C3 activator, but not by antisera to C4. This suggests that incubation with tea may alter the red cell membrane in a way that specifically potentiates the lytic effects of the alternate pathway of complement, but not the classic pathway. Leupeptin, a protease inhibitor, also prevented complement‐dependent hemolysis of red cells incubated with tea. Although the clinical consequences of these observations are unknown, the study was initiated following a report of a young male who had developed an acute limited intravascular hemolytic episode following ingestion of large quantities of a herbal tea.
Faith, Religion, and Healing
Authors: CLAUDE A. FRAZIER
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 May 1972Faith, Religion, and HealingCLAUDE A. FRAZIER, M.D.CLAUDE A. FRAZIER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-837_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I am editing a book on the role of faith or religion in healing from a physician's standpoint. Any physician interested in contributing to this book, please write to me at the address below.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 4-C Doctors Park Ashville, N.C. 28801 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 837-837 Issue Published: 1 May 1972 PDF downloadLoading ...
Young pregnant women lack help and support from doctors
Authors: Deborah Cohen
Journal: BMJ (2004)

Campaigners have criticised doctors for failing to provide adequate services for young pregnant women and have expressed concern over where women go for help and support.

Speaking at the launch of a new abortion education resource pack for teachers, Lisa Hallgarten, programme manager of Education for Choice, which helps young people to make an informed choice around pregnancy and abortion, said that women are being forced to travel for miles to have an abortion after 12 weeks.

“This is a problem that's growing in the medical profession as we know that …
Functional Promoter −1271G&gt;C Variant of <i>HSPB1</i> Predicts Lung Cancer Risk and Survival
Authors: Huan Guo, Yun Bai, Ping Xu, Zhibin Hu, Li Liu, Fang Wang, Guangfu Jin, Feng Wang, Qifei Deng, Yixiao Tu, Maohui Feng, Daru Lu, Hongbing Shen, Tangchun Wu
Journal: Journal of Clinical Oncology (2010)

Purpose Heat-shock protein 27 (Hsp27), encoded by HSPB1, plays crucial roles in tumorigenesis and cell survival and is reported to be an independent prognosis marker for cancer. We hypothesized that genetic variants of the HSPB1 gene may be associated with lung cancer susceptibility and survival. Patients and Methods We first resequenced the full-length HSPB1 gene and then genotyped three selected tag single nucleotide polymorphisms (SNPs) in 1,152 paired Chinese lung cancer patient cases and controls. Another 500 paired patient cases and controls were used for replication. We also evaluated the roles of these tagSNPs in the overall survival of 248 patients with advanced non–small-cell lung cancer (NSCLC), and validated the results in another 335 patients with advanced NSCLC. The genotype-phenotype correlation was assessed in 309 workers with occupational exposure to polycyclic-aromatic hydrocarbons (PAHs) as well as by luciferase reporter assay and Western blotting analysis. Results The −1271C allele was associated with a significantly increased lung cancer risk in the two independent patient case–control studies (P &lt; .05 for both), but it conferred a favorable survival for patients with advanced NSCLC in two independent cohorts (adjusted hazard ratio, 0.66 and 0.75, respectively). The occupational PAH-exposed workers carrying the −1271C allele showed higher DNA damage levels than those with the −1271G allele (P = .027). Furthermore, the −1271C allele significantly decreased luciferase activity in four cell lines and resulted in lower Hsp27 expression levels in normal lung tissues when compared with −1271G allele (P &lt; .05). Conclusion The functional HSPB1 promoter −1271G&gt;C variant may affect lung cancer susceptibility and survival by modulating endogenous Hsp27 synthesis levels.