tbuckley/cabot-search huggingface dataset:
FLUORESCENT MICROSCOPY OF THE HUMAN SKIN.
Authors: A. JARRETT, A. BLIGH, JOAN A. HARDY
Journal: British Journal of Dermatology (1956)

Journal Article FLUORESCENT MICROSCOPY OF THE HUMAN SKIN. Get access A. JARRETT, M.B., M.R.C.P.(Edin.), A. JARRETT, M.B., M.R.C.P.(Edin.) Dermatological Research Assistant Search for other works by this author on: Oxford Academic Google Scholar A. BLIGH, A.I.B.P., A.R.P.S., A. BLIGH, A.I.B.P., A.R.P.S. Photographer in Charge Search for other works by this author on: Oxford Academic Google Scholar JOAN A. HARDY JOAN A. HARDY Histological Technician to the Dermatological Department, University College Hospital Medical School, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 68, Issue 4, 1 April 1956, Pages 111–119, https://doi.org/10.1111/j.1365-2133.1956.tb12795.x Published: 01 April 1956
Lower oesophageal web
Authors: V. O. Bjork, C. G. Charonis
Journal: Thorax (1967)

A patient with a `congenital9 oesophageal web was suffering from dysphagia and was treated surgically. A review is made of a few similar, well-documented cases. An effort is made to compare the clinical and pathological characteristics of the lesion and to discuss its pathogenesis.
Abnormal high density lipoproteins in cerebrotendinous xanthomatosis.
Authors: V Shore, G Salen, F W Cheng, T Forte, S Shefer, G S Tint, F T Lindgren
Journal: Journal of Clinical Investigation (1981)

The plasma lipoprotein profiles and high density lipoproteins (HDL) were characterized in patients with the genetic disease cerebrotendinous xanthomatosis (CTX). Abnormalities in the HDL may contribute to their increased atherogenesis and excessive deposits of tissue sterols in the presence of low or low-normal concentrations of plasma cholesterol (165 +/- 25 mg/dl) and low density lipoproteins (LDL). The mean HDL-cholesterol concentration in the CTX plasmas was 14.5 +/- 3.2 mg/dl, about one-third the normal value. The low HDL-cholesterol reflects a low concentration and an abnormal lipid composition of the plasma HDL. Relative to normal HDL, the cholesteryl esters are low, free cholesterol and phospholipids essentially normal, and triglycerides increased. The ratio of apoprotein (apo) to total cholesterol in the HDL of CTX was two to three times greater than normal. In the CTX HDL, the ratio of apoAI to apoAII was high, the proportion of apoC low, and a normally minor form of apoAI increased relative to other forms. The HDL in electron micrographs appeared normal morphologically and in particle size. The abnormalities in lipoprotein distribution profile and composition of the plasma HDL result from metabolic defects that are not understood but may be linked to the genetic defect in bile acid synthesis in CTX. As a consequence, it is probable that the normal functions of the HDL, possibly including modulation of LDL-cholesterol uptake and the removal of excess cholesterol from peripheral tissues, are perturbed significantly in this disease.
Tobacco displays to be banned to prevent children smoking
Authors: Z. Kmietowicz
Journal: BMJ (2008)

Shops in England and Wales are to be banned from displaying cigarette and tobacco products to reduce impulse purchases. And age restrictions are to be placed on the use of vending machines to try to prevent children from starting smoking.

However, proposals to ban branding on tobacco products and to restrict cigarette sales to packets of 20 will not feature in the Health Bill, which will come before parliament in the next session.

Alan Johnson, health secretary, said, “Enticing multicoloured displays encourage young people to start smoking—we must put a stop to this. Smoking is a habit which is hard to break and causes 87 000 deaths a year in England alone.

“Protecting children from smoking is …
Coronary reactivity in the porcine heart after short lasting myocardial ischaemia: effects of duration of ischaemia and myocardial stunning
Authors: K. A. Kirkeboen, G. Aksnes, A. Ilebekk
Journal: Cardiovascular Research (1990)

Study objective – The aim was to characterise reactive hyperaemia and endothelium dependent (ADP) and independent (adenosine) vasodilatation after ischaemic periods of increasing duration, and in the stunned myocardium. Design – The left anterior descending coronary artery was occluded 5-7 cm distal from its origin for consecutive periods of 2, 2, 5, 10, and 2 min separated by 30 min of reperfusion. Coronary flow was continuously measured by Doppler flowmetry proximal to the occlusion site. ADP and adenosine were infused into the left coronary artery proximal to the flowprobe. Experimental material – 11 domestic pigs, weight 25-36 kg, were used. Measurements and main results – In the stunned myocardium maximal reactive hyperaemia after 2 min of ischaemia was preserved, whereas all other variables describing reactive hyperaemia were diminished: time to maximal hyperaemia by 40% (p<0.01), duration of hyperaemia by 44% (p<0.001), volume of hyperaemia by 53% (p<0.001), and repayment of flow debt by 43% (p<0.001). The vasodilating effects of ADP and adenosine (dose-response curves) were not altered after development of stunning. Conclusions – Preserved maximal hyperaemia and vasodilatation during ADP and adenosine infusion, but reduced volume of hyperaemia, indicate normal coronary reactivity but diminished release in the stunned myocardium of the vasodilator(s) responsible for the prolonged postischaemic flow increase.
Government favours “creative destruction” of the NHS
Authors: Adrian O'Dowd
Journal: BMJ (2006)

Hospitals may have to merge or start cutting back to deal with surplus capacity, doctors have been warned by an expert in health service policy.

An excess number of hospital beds was bringing about changes to the way the NHS operated and because of increasing competition might lead to some hospitals taking over others to survive, doctors heard at a London conference organised by the BMA, entitled Can We Make Sense of System Reform? 

Professor Chris Ham of the Health Services Management …
The Determination of Coronary Flow Equivalent with Coincidence Counting Technic
Authors: RICHARD J. BING, ARVIN BENNISH, GERHARD BLUEMCHEN, ALBERTO COHEN, JAMES P. GALLAGHER, EDWARD J. ZALESKI
Journal: Circulation (1964)

The coincidence counting technic was used to measure the clearance equivalent of rubidium-84 as a function of coronary flow by the human heart in vivo. This technic makes possible a distinction of radioactivity of the heart muscle from the surrounding tissue, eliminates lead collimation, and is more sensitive than the singles technic. In experiments on isolated dog heart it was found that changes in rate of perfusion of the coronary arteries failed to influence the myocardial extraction ratio of rubidium-84. Alterations in heart rate were also without effect. Nitroglycerin increased the clearance equivalent of rubidium-84 in patients without coronary heart disease. In patients with coronary artery disease the drug led to fall in clearance equivalent. The method has been helpful in distinguishing between normal individuals and those with coronary artery disease.
Genetic Screening of Sperm and Oocyte Donors
Authors: Judith F. Daar, Robert G. Brzyski
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reciprocal Regulation of Activating and Inhibitory Fcγ Receptors by TLR7/8 Activation: Implications for Tumor Immunotherapy
Authors: Jonathan P. Butchar, Payal Mehta, Steven E. Justiniano, Kristan D. Guenterberg, Sri-Vidya Kondadasula, Xiaokui Mo, Mahesh Chemudupati, Thirumala-Devi Kanneganti, Amal Amer, Natarajan Muthusamy, David Jarjoura, Clay B. Marsh, William E. Carson, John C. Byrd, Susheela Tridandapani
Journal: Clinical Cancer Research (2010)

Abstract Purpose: Activation of Toll-like receptors (TLR) 7 and 8 by engineered agonists has been shown to aid in combating viruses and tumors. Here, we wished to test the effect of TLR7/8 activation on monocyte Fcγ receptor (FcγR) function, as they are critical mediators of antibody therapy. Experimental Design: The effect of the TLR7/8 agonist R-848 on cytokine production and antibody-dependent cellular cytotoxicity by human peripheral blood monocytes was tested. Affymetrix microarrays were done to examine genomewide transcriptional responses of monocytes to R-848 and Western blots were done to measure protein levels of FcγR. Murine bone marrow–derived macrophages from WT and knockout mice were examined to determine the downstream pathway involved with regulating FcγR expression. The efficacy of R-848 as an adjuvant for antibody therapy was tested using a CT26-HER2/neu solid tumor model. Results: Overnight incubation with R-848 increased FcγR-mediated cytokine production and antibody-dependent cellular cytotoxicity in human peripheral blood monocytes. Expression of FcγRI, FcγRIIa, and the common γ-subunit was increased. Surprisingly, expression of the inhibitory FcγRIIb was almost completely abolished. In bone marrow–derived macrophage, this required TLR7 and MyD88, as R-848 did not increase expression of the γ-subunit in TLR7−/− nor MyD88−/− cells. In a mouse solid tumor model, R-848 treatment superadditively enhanced the effects of antitumor antibody. Conclusions: These results show an as-yet-undiscovered regulatory and functional link between the TLR7/8 and FcγR pathways. This suggests that TLR7/8 agonists may be especially beneficial during antibody therapy. Clin Cancer Res; 16(7); 2065–75. ©2010 AACR.
Scintigraphic Arthrography: A New Imaging Procedure
Authors: HUSSEIN M. ABDEL-DAYEM, YUNUS BARODAWALA, THEODORE PAPADEMETRIOU
Journal: Clinical Nuclear Medicine (1981)

ABDEL-DAYEM, HUSSEIN M. M.D.; BARODAWALA, YUNUS M.D.; PAPADEMETRIOU, THEODORE M.D. Author Information
A CASE OF TYPHOID PERFORATION OF THE INTESTINE WITH SURGICAL TREATMENT AND RECOVERY.
Authors: THOMAS W. HUNTINGTON
Journal: JAMA (1905)

<h3>Patient.</h3> Male, age 38, single; occupation, miner. Previous history unimportant. <h3>History.</h3> His illness began 37 days before he was admitted to the University of California wards in the San Francisco County Hospital. At that time he was working in the mines at Mojave. The onset was marked with weakness and dizziness and alternate diarrhea and constipation. He stopped work, but did not go to bed. After going from place to place for five weeks he was admitted to the hospital on Nov. 17, 1904. <h3>Examination.</h3> On entrance he had a temperature of 101.8 F., liver and spleen were slightly enlarged, there were roseola on abdomen, and tenderness and gurgling in right iliac fossa, diazo reaction was present, and the Widal reaction was present in dilution of 1 in 40 in 45 minutes; hemoglobin, 65 per cent.; leucocytes, 6,500. <h3>Treatment.</h3> Treatment for typhoid
INHIBITORY ACTION OF THE CEREBRUM.
Authors: J. F. PEAVY
Journal: JAMA (1899)

Irritability and contractility are primary properties of protoplasm. In their earliest forms they express the simple play of elementary chemical and physical forces. In undifferentiated protoplasm, they exist as general diffused properties of reacting to incident forces indifferently in all directions. The progressive differentiation of form and function expressive of organic progress implies the development of specific irritability or susceptibility to specific excitants, along with the capacity to react in definite ways to these excitants. It implies further the development of a nervous mechanism by which this special irritability is manifested, and through which the reactionary impulses are transmitted to be developed into organic activities. The special senses are special developments of this irritability, and the varied motor activities of animals are derivatives of this primary contractility manifested by protoplasm. All organic reactions involve a reflex element or factor in that they are in a sense responses to stimuli
Type A behaviour and ischaemic heart disease
Authors: J E J Gallacher
Journal: BMJ (1987)

We were pleased to see the recommendations for conservative measures but concerned by the im- pression given that for large, heavy limbs with reduced mobility surgery was the first option.Extensive experience reported by Foldi et al suggests that even severe and long term swelling may successfully be treated by a combination of massage, compression bandages or elastic hosiery, and exercise,3 surgery being required only to remove redundant skin.This has also been our experience.Effective treatment is, however, labour intensive.The best results are achieved at an early stage, when swelling is most reversible.Indeed, prophylatic treatment in high risk groups may be the way to limit the problem after treatment for cancer.Raising the arm in a sling should be abandoned as it is uncomfortable and probably offers no greater benefit than positioning the arm at, or just above, heart level.Arm raising results in auto- regulation with relative preservation of capillary pressure and flow.4This reduction in precapillary vasoconstriction tends to buffer any benefit gained from lowering venous pressure.Limb raising in lymphoedema is thus pointless unless complemented by subsequent external support.
Legionnaires' disease cluster and reduction in hospital hot water temperatures.
Authors: S R Palmer, I Zamiri, C D Ribeiro, A Gajewska
Journal: BMJ (1986)

D'apres les reglements officiels la temperature de l'eau chaude dans les hopitaux doit etre superieure a 50° et celle de l'eau froide inferieure a 20°, pour inhiber la croissance de Legionella pneumophila. Pendant un ete tres chaud, dans un hopital, on a abaisse la temperature de l'eau chaude d'environ 10°. 8 semaines plus tard 5 malades separes les uns des autres dans cet hopital ont presente la maladie des legionnaires. Aucun autre cas n'a ete observe apres retour a la temperature reglementaire
T-Cell Antigen Deficiencies and Clonal Rearrangements of T-Cell Receptor Genes in Pagetoid Reticulosis (Woringer-Kolopp Disease)
Authors: G S Wood, L M Weiss, C H Hu, E A Abel, R T Hoppe, R A Warnke, J Sklar
Journal: New England Journal of Medicine (1988)

PAGETOID reticulosis (Woringer-Kolopp disease) is a rare skin disorder consisting of solitary or localized, often hyperkeratotic, cutaneous plaques. Histologically, the involved areas of skin show a prominent infiltrate of cytologically atypical mononuclear cells within a hyperplastic epidermis.1 , 2 Clinically, these lesions are indolent. There have been reports that the condition has resolved in several patients after local surgery or radiation therapy; however, other patients have presented with a disseminated form of pagetoid reticulosis, the Ketron-Goodman variant.2 , 3 Some of these patients have also had typical lesions of mycosis fungoides, a form of cutaneous T-cell lymphoma, and have died.4 5 6 The nature of the . . .
Mechanical properties of myocardium from hypertrophied rat hearts. A comparison between hypertrophy induced by senescence and by aortic banding.
Authors: F C Yin, H A Spurgeon, M L Weisfeldt, E G Lakatta
Journal: Circulation Research (1980)

Cardiac hypertrophy is a characteristic change that occurs in senescence.Muscles from senescent as compared to mature hearts also demonstrate functional alterations that are similar to the alterations found in muscles from experimentally hypertrophied hearts.Thus, an attractive hypothesis is that functional alterations in senescent muscles are related to the underlying hypertrophy.To test this hypothesis, we used a rat model of aging in which experimental hypertrophy was produced by aortic banding.The time course and extent of cardiac hypertrophy, as well as isometric twitch and viscoelasticity parameters, as a function of age, first were determined in muscles from the rat hearts.Aortic banding then was performed on middle-aged rats to produce the same extent of hypertrophy as seen in the senescent hearts.The resulting functional alterations in muscles from the banded (B) hearts were compared to the senescent (S) and middle-aged (M) muscles.Using tibia] length as a reference, we found 14% LV hypertrophy in senescent compared to both young and middle-aged rats, indicating that the hypertrophy occurred during the last quarter of life.The S muscles demonstrated a 25% prolongation in contraction duration (CD) and a 30% increase in slope of the active stiffness-tension line (o A ) compared to both young adult and middle-aged muscles.Compared to middle-aged muscles, the B muscles demonstrated a similar spectrum of change in mechanical properties as the S muscles (8% increase in CD and 15% increase in a A ), but the quantitative differences between the B and S muscles were significant.Over the functional range of developed tensions, the B muscles demonstrated the lowest and the S muscles the highest values of stiffness.The findings suggest that a portion of the mechanical property alterations seen in the senescent heart are due to the underlying hypertrophy.However, the hypertrophy produced by mechanical loading of the LV cannot explain all of the senescent changes.
Metabolic alterations in middle-aged and elderly obese patients with type 2 diabetes.
Authors: G S Meneilly, T Elliott
Journal: Diabetes Care (1999)

OBJECTIVE: We conducted this study to assess the metabolic alterations in middle-aged and elderly obese patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: Healthy control subjects (9 middle-aged, aged 42 +/- 2 years, BMI 33 +/- 1 kg/m2; 10 elderly, aged 71 +/- 1 years, BMI 29 +/- 1 kg/m2) and patients with type 2 diabetes (11 middle-aged, aged 43 +/- 2 years, BMI 34 +/- 2 kg/m2; 23 elderly, aged 73 +/- 1 years; BMI 30 +/- 1 kg/m2) underwent a 3-h oral glucose tolerance test (OGTT), a 2-h hyperglycemic glucose clamp, and a 3-h euglycemic glucose clamp study with tritiated glucose methodology to measure hepatic glucose production and peripheral disposal rates. RESULTS: Middle-aged and elderly control subjects and patients with diabetes were similar in percentage of body fat. Waist-to-hip ratio was greater in elderly patients with diabetes than in elderly control subjects (P &amp;lt; 0.01), but was similar in both middle-aged groups. VO2max was less in control subjects than in both middle-aged and elderly patients with diabetes (P &amp;lt; 0.05). Insulin responses during the OGTT were similar in elderly control subjects and patients with diabetes, but were less in middle-aged patients with diabetes than in control subjects (305 +/- 49 vs. 690 +/- 136 pmol/l, P &amp;lt; 0.01). Patients with type 2 diabetes had absent first-phase insulin responses during the hyperglycemic clamp. Second-phase (80-120 min) insulin values were similar in elderly patients and control subjects, but were reduced in middle-aged patients with diabetes compared with control subjects (285 +/- 35 vs. 894 +/- 143 pmol/l, P &amp;lt; 0.0001). During the euglycemic clamp, basal and steady-state (150-180 min) hepatic glucose output values were less in middle-aged control subjects than in patients with diabetes (basal, 3.03 +/- 0.10 vs. 3.69 +/- 0.09 mg.kg-1 lean body mass.min-1, P &amp;lt; 0.0001; steady-state, 0.72 +/- 0.10 vs. 1.84 +/- 0.20 mg.kg-1 lean body mass.min-1, P &amp;lt; 0.0001). Basal and steady-state hepatic glucose output values were similar in elderly patients and control subjects. Finally, steady-state (150-180 min) glucose disposal rates were higher in control subjects than in patients with diabetes in both the middle-aged (7.51 +/- 0.85 vs. 4.62 +/- 0.24 mg.kg-1 lean body mass.min-1, P &amp;lt; 0.01) and elderly (9.91 +/- 0.61 vs. 6.78 +/- 0.60 mg.kg-1 lean body mass.min-1, P &amp;lt; 0.01) groups. CONCLUSIONS: We conclude that type 2 diabetes in obese middle-aged subjects is characterized by impaired glucose-induced insulin release, altered regulation of hepatic glucose output, and resistance to insulin-mediated glucose disposal. In contrast, the primary defect in elderly obese patients with type 2 diabetes is resistance to insulin-mediated glucose disposal. Our findings may have important therapeutic implications for these patient populations.
Clinical utility of Lens culinaris agglutinin-reactive alpha-fetoprotein in small hepatocellular carcinoma: special reference to imaging diagnosis
Authors: Takashi Kumada, Satoshi Nakano, Isao Takeda, Seiki Kiriyama, Yasuhiro Sone, Kazuhiko Hayashi, Hiromasa Katoh, Tomonori Endoh, Toshi Sassa, Shinji Satomura
Journal: Journal of Hepatology (1999)
Treatment for Hypertensive Crisis
Authors: J. BROOKS WATT
Journal: Annals of Internal Medicine (1977)

Comments and Corrections1 March 1977Treatment for Hypertensive CrisisJ. BROOKS WATT, M.D.J. BROOKS WATT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-3-366_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recently a case report of fatal myocardial infarction after intravenous diazoxide therapy appeared (1). I would like to ask the authors to clarify and expand the case history. Specifically, did the initial examination show fresh retinal hemorrhages, papilledema, congestive heart failure, encephalopathy, focal neurologic deficits, ECG signs of ischemia, or hematuria? According to the protocol, the patient had never had, nor was he having, chest pain.The above findings would fulfill the criteria for a "hypertensive crisis" (2) and require immediate aggressive therapy to lower blood pressure as was done. However, in some instances, one is faced...References1. MROCZEK W and LEE W: Diazoxide therapy: use and risks (Letter). Ann Intern Med 85:529, 1976 LinkGoogle Scholar2. KOCH-WESER J: Hypertensive emergencies. N Engl J Med 290: 211-214, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. BROOKS WATT, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypotensive drugs 1 March 1977Volume 86, Issue 3Page: 366-366KeywordsBlood pressureBrain diseasesHeart failureHemorrhageIschemiaMyocardial infarction ePublished: 1 December 2008 Issue Published: 1 March 1977 PDF downloadLoading ...