tbuckley/cabot-search huggingface dataset:
THE BACILLUS OF MEASLES. Dr. P. Canon and Dr. W. Pielicke.
Authors: Jacob Rosenthal
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The disease status of catatonia
Authors: Irwin Savodnik
Journal: Behavioral and Brain Sciences (2002)

Georg Northoff encounters a problem regarding the logical status of “catatonia.” Whereas Parkinson's disease (PD) is a disease on the basis of Virchowian criteria, catatonia is not. PD is associated with pathognomonic neurological lesions. Catatonia does not require any such association. The diagnosis is rendered using social criteria rather than neuropathological ones. Therefore, Northoff is not comparing two disease states at all.
Patient's Package Insert
Authors: Alfred Coodley
Journal: JAMA (1976)

<h3>To the Editor.—</h3> I both agree and disagree with Dr McMahon's reactions to the patient package insert issued by the FDA (233:1089, 1975). When I recently wrote "we must recognize that our fundamental Hippocratic responsibility must center upon every patient's best interests,"<sup>1</sup>I also meant that a realistic description of possible toxic reactions to a prescribed drug coupled with emphasizing its specific benefits is certainly indicated for some patients. As Dr McMahon pointed out, for other patients such discussion must be limited and sufficiently vague in order to minimize undue anxiety. Of course, one might feel much freer in discussing such potential problems with a patient's close relative. When the toxicity of a drug is being discussed, there is a crucial value in "universalizing the potential toxicity of every drug on the market, including even something as simple as aspirin."<sup>2</sup>If we carried the patient package insert to
Modeling metastasis biology and therapy in real time in the mouse lung
Authors: Arnulfo Mendoza, Sung-Hyeok Hong, Tanasa Osborne, Mohammed A. Khan, Kirk Campbell, Joseph Briggs, Ananth Eleswarapu, Lauren Buquo, Ling Ren, Stephen M. Hewitt, El-H. Dakir, Susan Garfield, Renard Walker, Glenn Merlino, Jeffrey E. Green, Kent W. Hunter, Lalage M. Wakefield, Chand Khanna
Journal: Journal of Clinical Investigation (2010)

Pulmonary metastasis remains the leading ca use of death for cancer patients. Opportunities to improve treatment outcomes for patients require new methods to study and view the biology of metastatic progression. Here, we describe an ex vivo pulmonary metastasis assay (PuMA) in which the metastatic progression of GFP-expressing cancer cells, from a single cell to the formation of multicellular colonies, in the mouse lung microenvironment was assessed in real time for up to 21 days. The biological validity of this assay was confirmed by its prediction of the in vivo behavior of a variety of high- and low-metastatic human and mouse cancer cell lines and the discrimination of tumor microenvironments in the lung that were most permissive to metastasis. Using this approach, we provide what we believe to be new insights into the importance of tumor cell interactions with the stromal components of the lung microenvironment. Finally, the translational utility of this assay was demonstrated through its use in the evaluation of therapeutics at discrete time points during metastatic progression. We believe that this assay system is uniquely capable of advancing our understanding of both metastasis biology and therapeutic strategies.
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer
Authors: Ali Amin Al Olama, Zsofia Kote-Jarai, Sonja I Berndt, David V Conti, Fredrick Schumacher, Ying Han, Sara Benlloch, Dennis J Hazelett, Zhaoming Wang, Ed Saunders, Daniel Leongamornlert, Sara Lindstrom, Sara Jugurnauth-Little, Tokhir Dadaev, Malgorzata Tymrakiewicz, Daniel O Stram, Kristin Rand, Peggy Wan, Alex Stram, Xin Sheng, Loreall C Pooler, Karen Park, Lucy Xia, Jonathan Tyrer, Laurence N Kolonel, Loic Le Marchand, Robert N Hoover, Mitchell J Machiela, Merideth Yeager, Laurie Burdette, Charles C Chung, Amy Hutchinson, Kai Yu, Chee Goh, Mahbubl Ahmed, Koveela Govindasami, Michelle Guy, Teuvo L J Tammela, Anssi Auvinen, Tiina Wahlfors, Johanna Schleutker, Tapio Visakorpi, Katri A Leinonen, Jianfeng Xu, Markus Aly, Jenny Donovan, Ruth C Travis, Tim J Key, Afshan Siddiq, Federico Canzian, Kay-Tee Khaw, Atsushi Takahashi, Michiaki Kubo, Paul Pharoah, Nora Pashayan, Maren Weischer, Borge G Nordestgaard, Sune F Nielsen, Peter Klarskov, Martin Andreas Røder, Peter Iversen, Stephen N Thibodeau, Shannon K McDonnell, Daniel J Schaid, Janet L Stanford, Suzanne Kolb, Sarah Holt, Beatrice Knudsen, Antonio Hurtado Coll, Susan M Gapstur, W Ryan Diver, Victoria L Stevens, Christiane Maier, Manuel Luedeke, Kathleen Herkommer, Antje E Rinckleb, Sara S Strom, Curtis Pettaway, Edward D Yeboah, Yao Tettey, Richard B Biritwum, Andrew A Adjei, Evelyn Tay, Ann Truelove, Shelley Niwa, Anand P Chokkalingam, Lisa Cannon-Albright, Cezary Cybulski, Dominika Wokołorczyk, Wojciech Kluźniak, Jong Park, Thomas Sellers, Hui-Yi Lin, William B Isaacs, Alan W Partin, Hermann Brenner, Aida Karina Dieffenbach, Christa Stegmaier, Constance Chen, Edward L Giovannucci, Jing Ma, Meir Stampfer, Kathryn L Penney, Lorelei Mucci, Esther M John, Sue A Ingles, Rick A Kittles, Adam B Murphy, Hardev Pandha, Agnieszka Michael, Andrzej M Kierzek, William Blot, Lisa B Signorello, Wei Zheng, Demetrius Albanes, Jarmo Virtamo, Stephanie Weinstein, Barbara Nemesure, John Carpten, Cristina Leske, Suh-Yuh Wu, Anselm Hennis, Adam S Kibel, Benjamin A Rybicki, Christine Neslund-Dudas, Ann W Hsing, Lisa Chu, Phyllis J Goodman, Eric A Klein, S Lilly Zheng, Jyotsna Batra, Judith Clements, Amanda Spurdle, Manuel R Teixeira, Paula Paulo, Sofia Maia, Chavdar Slavov, Radka Kaneva, Vanio Mitev, John S Witte, Graham Casey, Elizabeth M Gillanders, Daniella Seminara, Elio Riboli, Freddie C Hamdy, Gerhard A Coetzee, Qiyuan Li, Matthew L Freedman, David J Hunter, Kenneth Muir, Henrik Gronberg, David E Neal, Melissa Southey, Graham G Giles, Gianluca Severi, Michael B Cook, Hidewaki Nakagawa, Fredrik Wiklund, Peter Kraft, Stephen J Chanock, Brian E Henderson, Douglas F Easton, Rosalind A Eeles, Christopher A Haiman
Journal: Nature Genetics (2014)
Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage
Authors: Kai Sun, Jingyu Fan, Jingyan Han
Journal: Acta Pharmaceutica Sinica B (2015)

Ischemic stroke and ischemia/reperfusion (I/R) injury induced by thrombolytic therapy are conditions with high mortality and serious long-term physical and cognitive disabilities. They have a major impact on global public health. These disorders are associated with multiple insults to the cerebral microcirculation, including reactive oxygen species (ROS) overproduction, leukocyte adhesion and infiltration, brain blood barrier (BBB) disruption, and capillary hypoperfusion, ultimately resulting in tissue edema, hemorrhage, brain injury and delayed neuron damage. Traditional Chinese medicine (TCM) has been used in China, Korea, Japan and other Asian countries for treatment of a wide range of diseases. In China, the usage of compound TCM preparation to treat cerebrovascular diseases dates back to the Han Dynasty. Even thousands of years earlier, the medical formulary recorded many classical prescriptions for treating cerebral I/R-related diseases. This review summarizes current information and underlying mechanisms regarding the ameliorating effects of compound TCM preparation, Chinese materia medica, and active components on I/R-induced cerebral microcirculatory disturbances, brain injury and neuron damage.
Lack of cyanosis in cyanotic congenital heart disease: Authors' reply
Authors: R. Franklin, F. Macartney, K. Bull, D. Spiegelhalter
Journal: BMJ (1991)

Thyroid dysfunction and affective illness SIR,-Professor E Szabadi's editorial on thyroid dysfunction and affective illness raised the question of whether subclinical dysfunction of the thyroid has a role in affective illnesses.'Lithium is well recognised to affect thyroid hormones; cases of hypothyroidism and hyperthyroidism have been reported.2Primary affective disorders may themselves have a role in the development of autoimmune thyroid disease.A recent study was designed to determine whether the development of autoimmune thyroid disease was due to lithium treatment or depressive illness.4Three main groups were studied: a control group, patients receiving treatment other than lithium for depression, and patients receiving lithium for their manic depressive illness.All patients were clinically and biochemically euthyroid.The serum samples obtained were tested for thyroid microsomal and thyroglobulin antibodies.None of the controls were positive for thyroid antibodies, but 7-5% of the patients receiving treatment other than lithium for depression were positive for the antibodies.This, however, is not significantly high when compared with the incidence in the general population.'The patients receiving lithium for their manic depressive illness showed a greatly increased incidence of thyroid antibodies (20%), in keeping with results of other studies.' 6 The authors concluded that lithium treatment induces the formation of antibodies in susceptible people, which may lead to the development of thyroid disease in these patients.A larger study will be necessary to determine whether affective disorders alone play any part in the development of subclinical hypothyroidism.
Allopurinol during acute gout attacks did not differ from delayed allopurinol for pain or recurrence
Authors: Gerry R. Boss
Journal: Annals of Internal Medicine (2013)

Source Citation Taylor TH, Mecchella JN, Larson RJ, Kerin KD, Mackenzie TA. Initiation of allopurinol at first medical contact for acute attacks of gout: a randomized clinical trial. Am J Med. 2012;125:1126-34. 23098865
University of Manchester sports injury clinic.
Authors: C. S. Galasko, T. J. Menon, G. J. Lemon, A. J. Banks, M. A. Morris, M. S. Bourne, S. Bentley
Journal: British Journal of Sports Medicine (1982)

This paper reviews the work of the sports injury clinic based at the Student Health Centre, University of Manchester during its first eighteen months. A total of 852 patients including 46 Centre of Excellence athletes were treated. The results indicate that the establishment of such a specialised clinic is worthwhile, that the injured sportsmen should be treated by individuals trained and interested in the treatment of injured patients in general and that the commonest injuries are soft tissue injuries to the knee of ankle joint. A record card, designed for future computer analysis, is illustrated. It includes details of the sport, training, mechanism of injury, pathology and treatment.
THE INFLUENCE OF THE PUBLIC SCHOOLS ON BRAIN-BUILDING.
Authors: W. J. CONKLIN
Journal: JAMA (1884)

[Read before the Ohio State Sanitary Association, February 14, 1884.] The grandest work of the best civilization is the building of efficient brains. The school forms one of the most important factors in brain-building, and the manner in which its influence is exerted has very properly excited, during the past decade, general discussion in educational and sanitary circles. We do not ignore the deleterious influences which surround the child in the street and home, influences which are incomparably more powerful in sapping its physical vigor than any connected with its school life. But our text to-day limits us to one phase of the question, the<i>effect of school work upon the health of the pupils</i>. We engage in this inquiry in no spirit of hostility to the schools. We know they are training up men and women who are fully competent to discharge all of the duties of State or
A piece of my mind. Another language
Authors: M. Goldoft
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rapid Identification of Pneumococci
Authors: Cynthia W. Merrill, Jack M. Gwaltney, J. Owen Hendley, Merle A. Sande
Journal: New England Journal of Medicine (1973)

EARLY and specific therapy for acute bacterial pneumonia is important in reducing morbidity and mortality. Clinicians rely mainly on statistical probabilities and gram stains of the sputum to select appropriate antimicrobial therapy. This report discusses the clinical application of an additional technic that markedly improves the accuracy of identifying Streptococcus pneumoniae, still the most common cause of acute bacterial pneumonia in hospitalized adults.When pneumococci come in contact with homologous anticapsular serum, the capsular precipitin reaction (quellung reaction) occurs, and the pneumococcal capsule appears refractile under the microscope.1 , 2 In 1963 Lund developed "omniserum," a pool of concentrated rabbit antiserum . . .
Effect of vascular endothelial growth factor and its receptor KDR on the transendothelial migration and local trafficking of human T cells in vitro and in vivo
Authors: Monika Edelbauer, Dipak Datta, Ingrid H. C. Vos, Aninda Basu, Maria P. Stack, Marlies E. J. Reinders, Masayuki Sho, Katiana Calzadilla, Peter Ganz, David M. Briscoe
Journal: Blood (2010)
The mutational landscape of adenoid cystic carcinoma
Authors: Allen S Ho, Kasthuri Kannan, David M Roy, Luc G T Morris, Ian Ganly, Nora Katabi, Deepa Ramaswami, Logan A Walsh, Stephanie Eng, Jason T Huse, Jianan Zhang, Igor Dolgalev, Kety Huberman, Adriana Heguy, Agnes Viale, Marija Drobnjak, Margaret A Leversha, Christine E Rice, Bhuvanesh Singh, N Gopalakrishna Iyer, C Rene Leemans, Elisabeth Bloemena, Robert L Ferris, Raja R Seethala, Benjamin E Gross, Yupu Liang, Rileen Sinha, Luke Peng, Benjamin J Raphael, Sevin Turcan, Yongxing Gong, Nikolaus Schultz, Seungwon Kim, Simion Chiosea, Jatin P Shah, Chris Sander, William Lee, Timothy A Chan
Journal: Nature Genetics (2013)
Aetius’s Reports on Genital Warts
Authors: Niki Papavramidou, Anthony Karpouzis, Thespis Demetriou
Journal: JAMA Dermatology (2013)

Genital warts were widely known in the ancient world. We investigate the relatively unknown reports of the Byzantine physician and medical writer Aetius of Amida (circa fifth century ad), presenting his own observations and methods, while reporting those of other physicians or authors.
Abstract 17976: Biopsy-proven Myocarditis: Young Age, Female Gender and Right Ventricular Dysfunction at Diagnosis are Independent Predictors of Death or Transplantation in a Contemporary Prospective Series
Authors: Alida L Caforio, Annalisa Angelini, Fiorella Calabrese, Omar Paccagnella, Francesco Bagato, Ilaria Loddo, Stefania Bottaro, Luciano Daliento, Vera Renier, Gino Gerosa, Gaetano Thiene, Sabino Iliceto
Journal: Circulation (2010)

Clinical presentation in biopsy-proven myocarditis is variable and prognostic features, including the detection of viral genome by polymerase chain reaction (PCR) on endomyocardial biopsy (EMB) rem...
THE PREVALENCE AND CLINICAL SIGNIFICANCE OF CARINA-LA CONDUCTION AFTER SUCCESSFUL PULMONARY VEIN ISOLATION FOR ATRIAL FIBRILLATION
Authors: Takigawa Masateru, Yukihiko Yoshida, Takashi Yamamoto, Kiyotake Ishikawa, Natsuo Inoue, Yasushi Tatematsu, Mamoru Nanasato, Naoya Tsuboi, Haruo Hirayama
Journal: Journal of the American College of Cardiology (2010)
Assessing Quality of Care: Process Measures vs Outcomes Measures
Authors: Romana Hasnaim-Wynia
Journal: JAMA (1996)

<h3>To the Editor.</h3> —We were surprised that Dr Brook and colleagues<sup>1</sup>believe that "[q]uality-of-care reporting systems need to rely primarily on clinically valid process (vs outcomes) measures." Granted there remain technical and conceptual problems with outcomes measures: rare outcomes, like mortality, are insensitive measures of quality; many quality-of-life measures must rely on risk adjustment to form appropriate comparisons between various organizations and providers; and disease-specific outcomes measures are still in development. However, process measures are imperfect as well. Three facts argue for the use of outcomes measures at least as often as process measures for quality control. First, while outcomes are sometimes not sensitive as a measure of quality (the absence of a bad outcome does not necessarily imply good quality), the corollary is that process measures are not specific measures of quality (the mere presence of a process may not imply good quality). For example, a high level
INTER-ASSAY AGREEMENT TO DEFINE INADEQUATE CLOPIDOGREL RESPONSE
Authors: Kodlipet C. Dharmashankar, Jose-Luis Ferreiro, Masafumi Ueno, Andrew Darlington, Davide Capodanno, Bhaloo Desai, Ronald K. Charlton, Luis A. Guzman, Theodore A. Bass, Dominick J. Angiolillo
Journal: Journal of the American College of Cardiology (2010)
Psychotherapy in a Psychiatric Institution – Attitude and Process
Authors: Jarl Jörstad
Journal: Psychotherapy and Psychosomatics (1974)

I have tried to demonstrate how experiences with individual psychotherapy and milieu work within a mental hospital, over a number of years, have brought about an increasing understanding concerning the basic importance of a therapeutic <i>attitude</i> by those working in mental health services, and also the importance of well trained psychotherapists as models and supervisors. Increasing insight into psychodynamic and social factors, have also contributed to a process within the institution. Individual psychotherapy in the hospital has met with its limitations, due to ego weakness on the part of the patients, the lack of experienced psychotherapists, and the necessity of integrating psychotherapy according to several other offers of treatment and rehabilitation. This development led to a reorganization of the whole treatment milieu, towards a more consequent group system, in which the total therapeutic resources, including patients and staff, have been utilized in a better way. Even this has met with its limitations, partly due to human irrationality and the complexity of group processes, and partly due to the limitations which are built into such a large hospital system and the resulting value conflicts. We now find ourselves at a third stage of development, in which the trend shifts towards more outpatient activity, and towards more work with patients' families and their social situation.
Pattern of some parents' complaints against doctors must be recognised
Authors: R A Smith
Journal: BMJ (2002)

EDITOR—The cosignatories to Marcovitch's letter are not the only paediatricians who have been referred to the General Medical Council by parents of children with alleged fabricated illness (Munchausen's syndrome by proxy).1 In our department two of five consultants have been referred in similar circumstances. In both cases allegations against the doctors were unsubstantiated.

This abuse of complaints processes needs to …
Survey of 3765 cardiopulmonary resuscitations in British hospitals (the BRESUS Study): methods and overall results.
Authors: H. Tunstall-Pedoe, L. Bailey, D. A. Chamberlain, A. K. Marsden, M. E. Ward, D. A. Zideman
Journal: BMJ (1992)

OBJECTIVE--To determine the circumstances, incidence, and outcome of cardiopulmonary resuscitation in British hospitals. DESIGN--Hospitals registered all cardiopulmonary resuscitation attempts for 12 months or longer and followed survival to one year. SETTING--12 metropolitan, provincial, teaching, and non-teaching hospitals across Britain. SUBJECTS--3765 patients in whom a resuscitation attempt was performed, including 927 in whom the onset of arrest was outside the hospital. MAIN OUTCOME MEASURE--Survival after initial resuscitation, at 24 hours, at discharge from hospital, and at one year, calculated by the life table method. RESULTS--There were 417 known survivors at one year, with 214 lost to follow up. By life table analysis for every eight attempted resuscitations there were three immediate survivors, two at 24 hours, 1.5 leaving hospital alive, and one alive at one year. Survival at one year was 12.5% including out of hospital cases and 15.0% not including these cases. Each hospital year averaged 30 survivors at one year: three who had an arrest outside hospital, seven who had one in the accident and emergency department, seven in the cardiac care unit, 10 in the general wards, and three in other, non-ward areas. Within the hospitals survival rates were best in those who had an arrest in the accident and emergency department, the cardiac care unit, or other specialised units. Outcome varied 12-fold in subgroups defined by age, type of arrest, and place of arrest. CONCLUSION--71% of the mortality at one year in patients undergoing attempted resuscitation occurred during the initial arrest. Hospital resuscitation is life saving and cost effective and warrants appropriate attention, training, coordination, and equipment.
New design rules for driving innovation in access to secondary care in the NHS
Authors: H. Rogers, L. Maher, P. E Plsek
Journal: BMJ (2008)

Although access to secondary care in the UK has improved, more still needs to be done. <b>Hugh Rogers</b>, <b>Lynne Maher</b>, and <b>Paul Plsek</b> describe how understanding the unwritten rules could help us move towards more radical redesigns
Antibody fragment-conjugated polymeric micelles incorporating platinum drugs for targeted therapy of pancreatic cancer
Authors: Jooyeon Ahn, Yutaka Miura, Naoki Yamada, Tsukasa Chida, Xueying Liu, Ahram Kim, Ryuta Sato, Ryo Tsumura, Yoshikatsu Koga, Masahiro Yasunaga, Nobuhiro Nishiyama, Yasuhiro Matsumura, Horacio Cabral, Kazunori Kataoka
Journal: Biomaterials (2014)
Endoscope Disinfection Using Acidic Electrolytic Water
Authors: None Tsuji, None Kawano, None Oshita, None Ohmae, None Shinomura, None Miyazaki, None Hiraoka, None Matsuzawa, None Kamada, None Hori, None Maeda
Journal: Endoscopy (1999)

Background and Study Aims: The aim of the present study was to evaluate a new endoscope disinfector (WM-1) that uses acidic electrolytic water (AEW).