tbuckley/cabot-search huggingface dataset:
Do beta-adrenoceptor blocking drugs cause retroperitoneal fibrosis?
Authors: J P Pryor, W M Castle, D C Dukes, J C Smith, M E Watson, J L Williams
Journal: BMJ (1983)

The aetiology of retroperitoneal fibrosis is unknown. From time to time different drugs have been suggested as a cause, including beta adrenoceptor blocking agents. The notes of 100 hospital inpatients in whom retroperitoneal fibrosis had been diagnosed were surveyed to identify the date of onset of symptoms, the drugs prescribed before then, and the blood pressures on admission. Seventy one patients had diastolic pressures on admission of 90 mm Hg or more and 53 of these had pressures of at least 100 mm Hg despite 14 of the patients taking anti-hypertensive drugs at the time. Six patients had received beta-adrenoceptor blocking agents before the onset of symptoms and a further 24 received them subsequently. In particular, three patients continued treatment for at least six years after the diagnosis was made and surgery performed, without suffering a recurrence of retroperitoneal fibrosis. Besides beta-adrenoceptor drugs, diuretics and other hypotensive drugs were taken in amounts reflecting the pattern of drug use among hypertensive patients generally. Rather than being causal agents, the antihypertensive drugs were probably being used to treat hypertension associated with the retroperitoneal fibrosis, and our findings suggest that beta-adrenoceptor blocking agents do not cause retroperitoneal fibrosis.
Abstract 3942: The role of vHL and REDD1 in predicting sensitivity to targeted therapies in renal cell carcinoma
Authors: Christopher Blick, Anassuya Ramachandran, Robert McCormick, David Cranston, Adrian L. Harris
Journal: Cancer Research (2012)

Abstract There are currently 6 FDA approved therapies in metastatic renal cell carcinoma and their introduction has improved both time to progression and survival in these patients. Despite treatment with targeted therapies approximately 20% of patients do not respond and the remaining patients will most likely develop resistance during the first 18 months of treatment. The aim of this study was to identify a link between differences in sensitivity to targeted therapies, the vHL status and the expression of genes involved in the mTOR pathway in both historic and primary renal cancer cell lines. Drug sensitivity and gene expression data was analysed in 6 historic and 10 primary renal cancer cell lines obtained from nephrectomy specimens. Gene expression data was also available from an additional 68 renal tumours. We found that cell lines with mutated or absent vHL showed increased sensitivity to rapamycin (p&amp;lt;0.01) but not to other therapies. Gene expression data showed that the expression of REDD1 (regulated in development and DNA damage responses 1), a known HIF1 target gene which inhibits the mTORC1 pathway in response to hypoxic stress correlates with rapamycin sensitivity (R-squared = 0.64, p=0.05). REDD1 expression was also higher in renal tumours when compared with matched normal tissue (p&amp;lt;0.01) and was found to correlate with CAIX expression (R-squared = 0.47, p&amp;lt;0.01). CAIX expression is associated with reduced survival in renal cell carcinoma and so further analysis is being performed to establish a potential role of REDD1 as a prognostic marker. Our findings suggest that vHL status and the levels of REDD1 expression in renal cancer cell lines can predict sensitivity to rapamycin. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3942. doi:1538-7445.AM2012-3942
ESSENTIAL HYPERTENSION IN THE ELDERLY: HAEMODYNAMICS, INTRAVASCULAR VOLUME, PLASMA RENIN ACTIVITY, AND CIRCULATING CATECHOLAMINE LEVELS
Authors: FranzH. Messerli, HectorO. Ventura, LouisB. Glade, Kirsten Sundgaard-Riise, FrancisG. Dunn, EdwardD. Frohlich
Journal: The Lancet (1983)
Abstract 1579: Depletion of GAPDH promotes p53 signaling, cell senescence and altered response to chemotherapeutic agents in human carcinoma cells
Authors: Manali S. Phadke, Natalia Krynetskaia, Evgeny Krynetskiy
Journal: Cancer Research (2010)

Abstract Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is a pivotal enzyme of the glycolytic pathway; it also plays a role of a signaling/regulator molecule in several cellular networks. In this study, we used human lung carcinoma A549 and renal carcinoma UO-31 cell lines to elucidate the role of GAPDH in cell proliferation and cellular response to genotoxic drugs. Using RNA interference technology, we decreased GAPDH protein level 4-5-fold in A549 cells, and 2-3-fold in UO-31 cells. Depletion of GAPDH in cultured cells blocked cell cycle progression in G1 phase, and induced activation of p53 and accumulation of p21. Simultaneously, GAPDH-depleted cells manifested biomarkers of senescence as revealed by morphological changes and induction of SA-β-galactosidase activity. Inhibition of GAPDH synthesis in human carcinoma cells resulted in 3-4-fold ATP depletion, and induced cell growth arrest without AMPK phosphorylation. In contrast, inhibition of glycolysis by 2-deoxyglucose treatment resulted in decreased ATP level and AMPK phosphorylation but did not induce cell senescence. These results suggest that GAPDH depletion in A549 cell line activates p53 independently of AMPK activation, and mediates the induction of signaling pathways leading to senescence. Importantly, GAPDH knockdown in p53-proficient A549 and UO-31 cells resulted in 3-50-fold decreased cytotoxicity of antimetabolite drugs including deoxy-thioguanosine, cladribine, fluoro-ribouridine, fluoruracil, 2-chloroadenosine, mercaptopurine, azacytidine and cytarabine. The results of this study indicate that cytotoxic activity of antimetabolite nucleoside analogs is modulated by the status of GAPDH in the cancer cells. Cell senescence induced by depletion of GAPDH is a plausible mechanism of cell resistance to antimetabolites, a hypothesis being under investigation in our lab. In addition, our data indicate that GAPDH-depleting agents could be promising cytostatic drugs. This work was supported by NCI grant R01 CA104729 Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1579.
Multiplicity of glutamic acid decarboxylases (GAD) in vertebrates: molecular phylogeny and evidence for a new GAD paralog
Authors: P. T. Bosma, M. Blazquez, M. A. Collins, J. D. Bishop, G. Drouin, I. G. Priede, K. Docherty, V. L. Trudeau
Journal: Molecular Biology and Evolution (1999)

The evolution of chordate glutamic acid decarboxylase (GAD; EC 4.1.1.15), a key enzyme in the central nervous system synthesizing the neurotransmitter gamma-amino-butyric acid (GABA) from glutamate, was studied. Prior to this study, molecular data of GAD had been restricted to mammals, which express two distinct forms, GAD65 and GAD67. These are the products of separate genes and probably are derived from a common ancestral GAD following gene duplication at some point during vertebrate evolution. To enable a comprehensive phylogenetic analysis, molecular information of GAD forms in other vertebrate classes was essential. By reverse transcriptase-polymerase chain reaction (RT-PCR), partial nucleotide sequences of GAD were cloned from brains of zebra finch (Taeniopygia guttata), turtle (Trachemys scripta), goldfish (Carassius auratus), zebrafish (Danio rerio), and armoured grenadier (Coryphaenoides (Nematonurus) armatus, a deep-sea fish), and from the cerebral ganglion plus neural gland of Ciona intestinalis, a protochordate. Whereas GAD65 and GAD67 homologs were expressed in birds, reptiles, and fish, only a single GAD cDNA with equal similarities to both vertebrate GAD forms was found in the protochordate. This indicates that the duplication of the vertebrate GAD gene occurred between 400 and 560 million years ago. For both GAD65 and GAD67, the generated phylogenetic tree followed the general tree topology for the major vertebrate classes. In turtle, an alternative spliced form of GAD65, putatively encoding a truncated, nonactive GAD, was found. Furthermore, a third GAD form, which is equally divergent from both GAD65 and GAD67, is expressed in C. (N.) armatus. This third form might have originated from an ancient genome duplication specific to modern ray-finned fishes.
Ephexin1 Is Required for Structural Maturation and Neurotransmission at the Neuromuscular Junction
Authors: Lei Shi, Busma Butt, Fanny C.F. Ip, Ying Dai, Liwen Jiang, Wing-Ho Yung, Michael E. Greenberg, Amy K.Y. Fu, Nancy Y. Ip
Journal: Neuron (2010)
Color Atlas of Melanocytic Lesions of the Skin
Authors: Daniel G. Federman
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Voice Analysis and Behavior Pattern
Authors: Arthur F. Johnson
Journal: JAMA (1969)

To the Editor:—  I should like to comment on the article Voice Analysis for Detection of Behavior Pattern by Friedman, et al (208:828, 1969).  The usefulness of the proposed test in classifying subjects rests on the fact that the test procedure gave high results (greater than mean + 2 SD for the type B subjects) in 84% of type A subjects. In this instance 84% is 16 out of 19 subjects, a result compatible with a percentage anywhere from 60.4 to 96.6 (95% confidence limits) on the supposition that the patients were a random sample from a type A population. The result is, of course, more uncertain for the available sample of patients used because of possible bias.  A further problem arises because the test examiner knew the behavior type of six of the type A subjects used.  A fairer assessment for the test procedure would be ten out of
Abstract LB-249: Coffee drinking decreases background DNA strand breaks in humans: A randomized controlled trial
Authors: Gerhard Eisenbrand, Tamara Bakuradze, Roman Lang, Thomas Hofmann, Dorothea Schipp, Jens Galan, Elke Richling
Journal: Cancer Research (2014)

Abstract Effects of coffee consumption on the level of spontaneous DNA strand breaks in peripheral white blood cells have not been reported yet. In this human intervention study the impact of consuming a dark roast coffee blend on the level of spontaneous DNA strand breaks was investigated. Healthy men (n=84) were randomized to consume daily for 4 weeks either 750 ml of fresh coffee brew or 750 ml of water, subsequent to a run in washout phase of 4 weeks. The study coffee was a blend providing substantial amounts of both, caffeoylquinic acids and the roast product N-methylpyridinium. Before and after the coffee/water phases, spontaneous strand breaks were determined by Comet assay. Both groups exhibited a similar level of spontaneous DNA strand breaks at baseline.In the intervention phase spontaneous ( background) DNA strand breaks slightly increased in the water only group, whereas they significantly decreased in the coffee group,leading to a 27 percent difference between both arms (p=0.0002). Food frequency questionnaires indicated no differences in the overall diet between groups, mean body weight during the intervention phases remaining stable. Consumption of the study coffee was found associated with a markedly lower level of pontaneous DNA strand breaks in white blood cells. Conclusion: Regular coffee consumption contributes to DNA integrity. Citation Format: Gerhard Eisenbrand, Tamara Bakuradze, Roman Lang, Thomas Hofmann, Dorothea Schipp, Jens Galan, Elke Richling. Coffee drinking decreases background DNA strand breaks in humans: A randomized controlled trial. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-249. doi:10.1158/1538-7445.AM2014-LB-249
The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia
Authors: Terry Langer, Warren Strober, Robert I. Levy
Journal: Journal of Clinical Investigation (1972)

The metabolism of low density lipoprotein (LDL, beta lipoprotein) was studied in 10 normal individuals and 10 patients with familial type II hyperlipoproteinemia using purified radioiodinated LDL. Over 97% of the label was bound to the protein moiety of LDL and therefore the turnover data reflect the fate and distribution of LDL-apoprotein. Comparison of the metabolic behavior of biologically screened and unscreened labeled LDL preparations in dogs as well as the analysis of the urinary excretion of radioiodide derived from labeled LDL degradation in humans indicated that no significant denaturation resulted from the isolation, purification, and labeling techniques. The plasma concentration of LDL-cholesterol in normals was 105+/-21 mg/100 ml (mean +/-1 SD) in contrast to 254+/-47 mg/100 mg in patients with type II hyperlipoproteinemia; these values corresponded to LDL-apoprotein concentrations of 63+/-13 mg/100 ml and 153+/-30 mg/100 ml, respectively. Despite these differences in concentration, the synthetic rate of LDL-apoprotein in both groups was not significantly different (14.43+/-1.75 mg/kg per day in normals vs. 15.01+/-1.71 mg/kg per day in type II) nor was there any difference in the fraction of the total exchangeable LDL which was in the intravascular space (68.4+/-4.3% vs. 73.3+/-5.2%). However, the fractional catabolic rate of LDL in normal individuals differed significantly from that of patients with type II hyperlipoproteinemia (0.462+/-0.077/day in normals vs. 0.237+/-0.044/day in type II) and correspondingly the biological half-life of LDL was significantly prolonged (3.08+/-0.35 days normals vs. 4.68+/-0.44 days in type II). These data indicate that the pathologic elevation of plasma LDL concentration in the individuals with type II hyperlipoproteinemia studied here is due to a decreased fractional rate of LDL degradation rather than to an abnormality of LDL synthesis. This defect of catabolism may be the primary defect in type II hyperlipoproteinemia or, alternatively, may be secondary to an underlying abnormality in lipid metabolism.
Endoscopic Resection of Large Colonic Lipomas Assisted by a Prototype Single-Use Endoloop Device
Authors: J. Koo, A. Kaffes
Journal: Endoscopy (2006)

Colonic lipomas are benign adipose tumors that occasionally cause symptoms. Endoscopic resection of large lipomas may be associated with the risk of hemorrhage or perforation. Experience with endoscopic resection of colonic lipomas with the assistance of a prototype single-use ligating Endoloop device, with a detachable snare unit, has not been previously reported. Three patients with a total of four large symptomatic colonic lipomas successfully underwent endoscopic resection with the aid of this device. One patient had self-limiting minor rectal bleeding which settled without consequence. All patients were well on follow-up, with resolution of their symptoms. This novel endoscopic technique should be considered during resection of large lipomas (> 10 mm diameter) to reduce the potential risk of bleeding.
HAIR AND ITS ANOMALIES.
Authors: HENRY ALFRED ROBBINS
Journal: JAMA (1900)

The poets and sculptors of Ancient Greece have left in verse and marble their admiration of long hair. The Hebrews also looked upon hair as a great ornament, and their women gloried in their luxuriant tresses, bedecked with gold and precious stones (Isaiah iii). The men usually kept their hair short, but there were notable exceptions, as with Absalom and Sampson. With the latter it was accompanied with superhuman strength, and when Delilah, during his sleep, cut off his flowing locks, his strength was gone: "Howbeit the hair of his head begun to grow again, after he was shaven." "But the Philistines took him and put out his eyes and brought him down to Gaza, and bound him with fetters of brass, and he did grind in the prison house'" (Judges xvi). When his hair had grown again his enemies sent for him that "he may make us sport." "And
Novel targeted deregulation of c-Myc cooperates with Bcl-XL to cause plasma cell neoplasms in mice
Authors: Wan Cheung Cheung, Joong Su Kim, Michael Linden, Liangping Peng, Brian Van Ness, Roberto D. Polakiewicz, Siegfried Janz
Journal: Journal of Clinical Investigation (2004)

Deregulated expression of both Myc and Bcl-XL are consistent features of human plasma cell neoplasms (PCNs). To investigate whether targeted expression of Myc and Bcl-XL in mouse plasma cells might lead to an improved model of human PCN, we generated Myc transgenics by inserting a single-copy histidine-tagged mouse Myc gene, MycHis, into the mouse Ig heavy-chain Cα locus. We also generated Bcl-XL transgenic mice that contain a multicopy Flag-tagged mouse Bcl-xFlag transgene driven by the mouse Ig κ light-chain 3′ enhancer. Single-transgenic Bcl-XL mice remained tumor free by 380 days of age, whereas single-transgenic Myc mice developed B cell tumors infrequently (4 of 43, 9.3%). In contrast, double-transgenic Myc/Bcl-XL mice developed plasma cell tumors with short onset (135 days on average) and full penetrance (100% tumor incidence). These tumors produced monoclonal Ig, infiltrated the bone marrow, and contained elevated amounts of MycHis and Bcl-XLFlag proteins compared with the plasma cells that accumulated in large numbers in young tumor-free Myc/Bcl-XL mice. Our findings demonstrate that the enforced expression of Myc and Bcl-XL by Ig enhancers with peak activity in plasma cells generates a mouse model of human PCN that recapitulates some features of human multiple myeloma.
Psychiatric Care of Coronary Artery Disease in a Cardiac Rehabilitation Unit
Authors: Maximino Lozano, Carmen Carcedo, Rosario Artigao, David Huertas, Ana O’Neill of Tyrone, Carmelo Pelegrin, J.M. Maroto, Llnis Jordá
Journal: Psychotherapy and Psychosomatics (1989)

The present work describes the psychiatric intervention in the Ramón y Cajal Hospital (Madrid) Cardiac Rehabilitation Program for Coronary Disease patients. The psychopathological concepts in relation to coronary heart disease are reviewed and studied in the foregoing acute and rehabilitation phases. The evaluation and therapeutic intervention methods are related in detail. Finally, results obtained in 90 patients who were treated in the past 3 years are analyzed. We mainly focused on the psychological risk factors and the psychosocial aspects.
Changes of α1-adrenergic receptors in human liver during intraabdominal sepsis
Authors: Tsann-Long Hwang, Ying-Tung Lau, Shu-Fang Huang, Miin-Fu Chen, Maw-Shung Liu
Journal: Hepatology (1994)

We studied changes in alpha 1-adrenergic receptors in human liver plasma membranes during intraabdominal sepsis using [3H]prazosin as a radioligand. Human liver tissues were obtained from nonseptic patients undergoing elective abdominal surgery (control group) and from patients with sepsis requiring laparotomy as a therapeutic measure (septic group). Septic patients were further divided into three subgroups on the basis of septic severity scores: mild sepsis (< 21), moderate sepsis (22 to 32) and severe sepsis (> 33). Plasma membranes were prepared by means of sucrose gradient centrifugation and were purified fivefold on the basis of the enrichment of the activity of the marker enzyme, 5'-nucleotidase. [3H]prazosin-binding studies show that the maximal binding capacity was increased by 49.6% (p < 0.01) in mild sepsis, relatively unchanged in moderate sepsis and decreased by 33.4% (p < 0.05) in severe sepsis (in femtomoles per milligram: 193.7 +/- 5.7 for control [n = 6], 289.8 +/- 23.4 for mild sepsis [n = 4], 192.3 +/- 16.3 for moderate sepsis (n = 4), 129.1 +/- 18.3 for severe sepsis [n = 5]). We found a significant inverse correlation (r = 0.85, p < 0.01) between changes in the densities of alpha 1-adrenergic receptors and septic severity scores. These data indicate that alpha 1-adrenergic receptors in human liver plasma membranes undergo dynamic changes during the development of sepsis--that is, the receptor number increased in mild sepsis, returned to a normal level in moderate sepsis and finally decreased in severe sepsis.(ABSTRACT TRUNCATED AT 250 WORDS)
Nous vous présentons le JAMA-français
Authors: Catherine D. DeAngelis, Robert A. Musacchio, Michael Clarke, Annette Flanagin
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal