The Effect of Beta Adrenergic Blockade on Patterns of Urinary Sodium Excretion
Authors: STEPHEN E. EPSTEIN
Journal: Annals of Internal Medicine (1966)

Article1 July 1966The Effect of Beta Adrenergic Blockade on Patterns of Urinary Sodium ExcretionStudies in Normal Subjects and in Patients with Heart DiseaseSTEPHEN E. EPSTEIN, M.D., EUGENE BRAUNWALD, M.D., F.A.C.P.STEPHEN E. EPSTEIN, M.D., EUGENE BRAUNWALD, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-1-20 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwo of the more prominent manifestations of impaired cardiac function are an inability to augment the cardiac output appropriately in response to increased metabolic demands, and a diminished ability to excrete sodium, with resultant fluid accumulation and edema. Since it has recently been observed that the cardiac response to maximal and submaximal levels of exercise in both normal subjects and patients with various forms of heart disease is reduced by blockade of the beta adrenergic receptors (1), it became of interest to determine if this impairment of hemodynamic performance is associated with changes in the patterns of sodium excretion. A...References1. EPSTEINROBINSONKAHLERBRAUNWALD SEBFRLE: Effects of beta-adrenergic blockade on the cardiac response to maximal and submaximal exercise in man. J. Clin. Invest. 44: 1745, 1965. CrossrefMedlineGoogle Scholar2. STOCKDALE JPN: Beta-adrenergic receptor blockade in cardiac arrhythmias. Brit. Med. J. 2: 1230, 1963. CrossrefMedlineGoogle Scholar3. TAYLORJOHNSTONJOSE RRCIAD: Reversal of digitalis intoxication by beta-adrenergic blockade with pronethalol. New Eng. J. Med. 271: 877, 1964. CrossrefMedlineGoogle Scholar4. 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EPSTEIN, M.D., EUGENE BRAUNWALD, M.D., F.A.C.P.Mechanisms of Contraction of the Normal and Failing HeartNewer Drugs in the Treatment of Cardiac ArrhythmiaAmelioration of Angina Pectoris in Idiopathic Hypertrophic Subaortic Stenosis with Beta-Adrenergic BlockadeCLINICAL AND HEMODYNAMIC APPRAISAL OF BETA ADRENERGIC BLOCKING DRUGSBeta-Adrenergic Receptor Blocking Drugs 1 July 1966Volume 65, Issue 1Page: 20-27KeywordsCardiac outputCardiovascular therapyEdemaExcretionExerciseHeartHeart diseasesHemodynamicsIngestionSodium Issue Published: 1 July 1966 PDF downloadLoading ...