Intravenous Acyclovir and Neurologic Effects
Authors: CARL V. VARTIAN
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 October 1983Intravenous Acyclovir and Neurologic EffectsCARL V. VARTIAN, M.D., DAVID M. SHLAES, M.D., PH.D.CARL V. VARTIAN, M.D.Search for more papers by this author, DAVID M. SHLAES, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-4-568_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read the report of Wade and Meyers (1) with interest as we have also seen a case of transient neurologic deterioration associated with intravenous acyclovir.A 56-year-old black woman was diagnosed as having hypereosinophilic syndrome in May 1982 when she presented with cough and dyspnea. Results of transbronchial and skin biopsies showed eosinophilic infiltrates. Prednisone and hydroxyurea were started. In June 1982, the patient had dysphagia. An esophagoscopic examination showed herpes simplex. On hospital day 8, intravenous acyclovir therapy was initiated at a dose of 250 mg/m2body surface area every 8 hours. On the following...References1. WADEMEYERS JJ. Neurologic symptoms associated with parenteral acyclovir treatment after marrow transplantation. Ann Intern Med. 1983;98:921-5. LinkGoogle Scholar2. SARALBURNSLASKINSANTOSLEITMAN RWOGP. Acyclovir prophylaxis of herpes-simplex-virus infections: a randomized, double-blind, controlled trial in bone-marrow-transplant recipients. N Engl J Med. 1981;305:63-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CARL V. VARTIAN, M.D.; DAVID M. SHLAES, M.D., PH.D.Affiliations: Cleveland Veterans Administration Medical Center Cleveland, OH 44106 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA Case Report of Neurotoxicity After Prolonged Doses of Acyclovir in a Patient With Renal DysfunctionAn unexpectedly high occurrence of aciclovir-induced neuropsychiatric symptoms in patients treated for herpesvirus CNS infection: a prospective observational studySevere mental disorders following anti-retroviral treatment in a patient on peritoneal dialysis: A case report and literature reviewCase Files of the Harvard Medical Toxicology Fellowship: Valacyclovir Neurotoxicity and Unintentional OverdoseValacyclovir-Associated Neurotoxicity in Peritoneal Dialysis PatientsAntiinfective Agents Affecting Cognition: A ReviewThe aciclovir metabolite CMMG is detectable in the CSF of subjects with neuropsychiatric symptoms during aciclovir and valaciclovir treatmentMedikamentös induzierte Psychose bei einer HIV-infizierten PatientinDistinguishing acyclovir neurotoxicity from encephalomyelitisAcyclovir-induced neurotoxicity: Concentration-side effect relationship in acyclovir overdoseFever, Pulmonary Infiltrates, and Pleural Effusion following Acyclovir Therapy for Herpes Zoster OphthalmicusMiscellaneous antibacterial and antiviral drugsAcyclovir-Associated Fever: A Case ReportAcyclovir: Neurologic and Renal ToxicityPAULA G. JONES, M.D., SUE A. BEIER-HANRATTY, M.D.Eosinophilic meningitis and the hypereosinophilic syndrome. Case report and review of the literatureAcyclovir and Behçet's SyndromeLUIGI RESEGOTTI, M.D., MARIANGELA PISTONE, M.D. 1 October 1983Volume 99, Issue 4Page: 568-568KeywordsBiopsyBody surface areaDysphagiaDyspneaHerpes simplex ePublished: 1 December 2008 Issue Published: 1 October 1983 PDF downloadLoading ...