Measuring Serum Immune Complexes in Cancer
Authors: ROGER D. ROSSEN
Journal: Annals of Internal Medicine (1978)

Editorial Notes1 April 1978Measuring Serum Immune Complexes in CancerROGER D. ROSSEN, M.D., BRIAN C. BARNES, M.D.ROGER D. ROSSEN, M.D.Search for more papers by this author, BRIAN C. BARNES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-4-570 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCirculating tumor antigen-antibody complexes appear to have a role in modulating cell-mediated immune responses against autologous tumors (1, 2). The usual effect is to suppress or block lymphocyte transformation and the generation of tumor-specific cytotoxic lymphocytes (2, 3). New techniques that permit measurement of the low levels of immune complexes in body fluids now make possible testing of the hypothesis that measurement of immune complexes in sera of cancer patients may be useful in detecting the residual tumor, in staging cancer, and in estimating prognosis (4).In various human malignant diseases, levels of immune complexes, as measured by the Clq...References1. SJOGRENHELLSTROMBANSALWARNERHELLSTROM HISGK: Elution of "blocking factors" from human tumors, capable of abrogating tumor-cell destruction by specifically immune lymphocytes. Int J Cancer 9:274-283, 1972 CrossrefMedlineGoogle Scholar2. SJOGRENHELLSTROMBANSALHELLSTROM HISK: Suggestive evidence that "blocking antibodies" of tumor-bearing individuals may be antigen-antibody complexes. Proc Natl Acad Sci USA 68:1372-1375, 1971 CrossrefMedlineGoogle Scholar3. 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SOBELBOKISCHMULLER-EBERHARD AVH: Clq deviation test for the detection of immune complexes, aggregates of IgG, and bacterial products in human serum. J Exp Med 142:139-150, 1975 CrossrefMedlineGoogle Scholar13. MORANTURKRYDERWATERS CJGM: Evidence for circulating immune complexes in lepromatous leprosy. Lancet 2:572-573, 1972 CrossrefMedlineGoogle Scholar14. TACHOVSKYKOPROWSKILISAKTHEOFILOPOULOSDIXON THRAF: Circulating immune complexes in multiple sclerosis and other neurological diseases. Lancet 2:997-999, 1976 CrossrefMedlineGoogle Scholar15. ROSSENREISBERGSINGERSCHLOEDERSUKIHILLEKNOYAN RMDFWLG: Soluble immune complexes in sera of patients with nephritis. Kidney Int 10:256-263, 1976 CrossrefMedlineGoogle Scholar16. GABRIELAGNELLO AV: Detection of immune complexes. The use of radioimmunoassays with C1q and monoclonal rheumatoid factor. J Clin Invest 59:990-1001, 1977 CrossrefMedlineGoogle Scholar17. ROSSENZUBLERDAYREISBERGMORGANGUTTERMANHERSH RRNMAJE: Detection of immune complex-like materials in cancer patients' sera: a comparative study of results obtained with the C1q deviation and C1q binding tests. J Lab Clin Med, 91:191-204, 1978 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Departments of Microbiology and Immunology, and Internal Medicine Baylor College of Medicine Veterans Administration Hospital Houston, Texas PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrognostic Significance of Circulating Immune Complexes in Cancer PatientsT helper-cell leukemia/lymphoma: Presentation as an acute immune-mediated illnessClinical Significance and Nature of Circulating Immune Complexes in Melanoma PatientsClinical Relevance of Immune Complexes, Associated Antigen, and Antibody in CancerResults of Immune Complex Detection in Human Glomerular DiseasesImmune complexes in ovarian cancerMusculoskeletal syndromes associated with malignancyCirculating immune complexes in colon cancer patient sera 1 April 1978Volume 88, Issue 4Page: 570-571KeywordsAntigensBody fluidsImmune complexImmune responseImmune serumLymphocytesVeteran care ePublished: 1 December 2008 Issue Published: 1 April 1978 PDF downloadLoading ...