tbuckley/cabot-search huggingface dataset:
Propranolol Erectile Dysfunction Relieved
Authors: JØRN BATHEN
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 May 1978Propranolol Erectile Dysfunction RelievedJØRN BATHEN, M.D.JØRN BATHEN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-5-716_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Three letters in recent issues of this journal (1-3) have drawn attention to erectile dysfunction induced by propranolol. I wish to report a case in which the patient regained normal sexual function when another beta-blocking drug, atenolol, was substituted for propranolol.A 44-year-old man with Wolff-Parkinson-White syndrome type B had frequent attacks of re-entry tachycardia with the normal pathway for antegrade and the accessory pathway for retrograde conduction. Propranolol, 40 mg two times daily, gave some, but not satisfactory, reduction of tachycardia attacks. Elevation of the dose to 80 mg two times daily gave further reduction and...References1. KNARR J: Impotence from propranolol (letter)? Ann Intern Med 85:259, 1976 LinkGoogle Scholar2. MILLER R: Propranolol and impotence (letter). Ann Intern Med 85:682-683, 1976 LinkGoogle Scholar3. WARRENWARREN SS: Propranolol and sexual impotence (letter). Ann Intern Med 86:112, 1977 LinkGoogle Scholar4. SIMPSON W: Nature and incidence of unwanted effects with atenolol. Postgrad Med J 53 (suppl 3):162-167, 1977 MedlineGoogle Scholar5. ZACHARIASCOWEN FK: Comparison of propranolol and atenolol in hypertension. Postgrad Med J 53 (suppl 3):111-113, 1977 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University Hospital 7000 Trondheim Norway PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIs essential tremor a single entity?Sexual Pharmacology: Love Potions, Pills, and PoisonsPharmaceuticalsHypertension and Erectile DysfunctionThe Impact of First-Line Antihypertensive Drugs on Erectile DysfunctionBisoprolol and Hypertension: Effects on Sexual Functioning in MenCardiac disease and sexual dysfunctionSexual dysfunction in hypertensive men. A critical review of the literature.Diagnosis and Treatment of Erectile ProblemsErectile Dysfunction Associated with Pharmacological AgentsSexual Dysfunction Due to Antihypertensive AgentsSexual dysfunction associated with oral antihypertensive medication: A critical survey of the literaturePharmacosexology: The Effects of Drugs on Sexual Function – A Review 1 May 1978Volume 88, Issue 5Page: 716-717KeywordsDrugsErectile dysfunctionTachycardia Issue Published: 1 May 1978 PDF downloadLoading ...
Angiotensin II increases spontaneous contractile frequency and stimulates calcium current in cultured neonatal rat heart myocytes: insights into the underlying biochemical mechanisms.
Authors: I S Allen, N M Cohen, R S Dhallan, S T Gaa, W J Lederer, T B Rogers
Journal: Circulation Research (1988)

The effect of angiotensin II on cultured neonatal rat heart myocytes was studied by measuring changes in cell length, the magnitude and kinetics of the calcium current, and changes in cyclic adenosine 3',5'-monophosphate (cAMP) and phosphoinositide metabolism. Spontaneous beating frequency of multicellular networks was increased by angiotensin II with a maximal increase of 100% above control values at concentrations of 5 nM or greater. The half-maximal response occurred at 0.6 nM angiotensin II. Shortening amplitude, shortening velocity, and relaxation velocity decreased concomitantly with the increasing contractile rate. In voltage-clamped single myocytes, both steady-state and transient components of the calcium current were increased by the addition of angiotensin II. Angiotensin II had no effect on either control or isoproterenol-stimulated adenylate cyclase activity in myocyte membranes. Neither the basal levels nor the isoproterenol-stimulated cAMP accumulation in intact cells was affected by addition of hormone. In myocytes labeled with [3H]inositol, angiotensin II stimulated the formation of [3H]inositol phosphates. One minute after addition of 5 nM angiotensin II, inositol monophosphate and inositol bisphosphate levels were increased to 73% and 99%, respectively, above control values and remained elevated at 10 minutes. Inositol trisphosphate levels were not significantly different from control values at either time point. Nifedipine (10 microM) had no effect on angiotensin II-induced increases in [3H]inositol phosphates. We conclude that the increases in both spontaneous beating rate and calcium current in angiotensin II-stimulated cultured neonatal heart cells are not dependent on cAMP or inositol trisphosphate levels but may involve sustained phosphoinositide hydrolysis.
Back pain--what can we offer?
Authors: A Calin
Journal: BMJ (1979)

treat local swelling with oral antihistamines.A patient with any systemic manifestations should be given a Medihaler-Epi as well as antihistamine tablets, although it is doubtful if any medication will be absorbed by the gastric mucosa after a sting.Although there may be few actual fatalities from insect stings, the number of nearfatalities and of incidents terrifying to patients and their relatives must, to judge by the number seen at our clinic, be high.Some attempt should therefore be made to protect acutely sensitive patients.The best method available at present is hyposensitisation and the pure venom extracts mentioned in your article should become available in a few weeks.
Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response.
Authors: L P Boulet, K R Chapman, J Côté, S Kalra, R Bhagat, V A Swystun, M Laviolette, L D Cleland, F Deschesnes, J Q Su, A DeVault, R B Fick, D W Cockcroft
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Inhaled allergens, acting through IgE-dependent mechanisms, are important triggers of asthma symptoms and inducers of airway hyperresponsiveness and airway inflammation. The effect of anti-IgE recombinant humanized monoclonal antibody-E25 (rhuMAb-E25) on the provocation concentration of allergen causing a 15% fall in FEV1 (allergen PC15) during the allergen-induced early asthmatic response (EAR) was assessed in a multicenter, randomized, double-blind, parallel group study. Ten of 11 allergic asthmatic subjects randomized to receive intravenous rhuMAb-E25, 2 mg/kg on study day 0 and 1 mg/kg on Days 7, 14, 28, 42, 56, and 70 completed the study; nine received intravenous placebo. The allergen PC15 was measured on Days -1, 27, 55, and 77 and methacholine PC20 on Days -2, 42, and 76. rhuMAb-25 was well tolerated and only one patient (active group) was withdrawn because of a generalized urticarial rash after the first dose. Compared with baseline values (Day -1), the median allergen PC15 on Days 27, 55, and 77 were increased by 2.3, 2.2, and 2.7 doubling doses (delta log PC15/0.3) respectively with rhuMAb-E25 and -0.3, +0.1, and -0.8 doubling doses with placebo (p < or = 0.002). Methacholine PC20 improved slightly after rhuMAb-E25, this change becoming statistically significant on Day 76 (p < 0.05); no change was observed in the placebo group. Mean serum-free IgE fell by 89% after rhuMAb-E25 while there was no significant change after placebo. The inhibitory effects of rhuMAb-E25 on allergen-induced EAR suggest that it may be an effective, novel antiallergic treatment for asthma.
How women view postepisiotomy pain.
Authors: A E Reading, C M Sledmere, D N Cox, S Campbell
Journal: BMJ (1982)

Episiotomy is one of the most commonly performed operative procedures and yet little information is available on the subjective reactions in the puerperium to this procedure. The present study was designed to furnish information on the attitudes of patients, levels of pain, and of course recovery by studying a consecutive series of 101 Caucasian primiparea who received episiotomies at delivery. Women were interviewed within 24 hours of delivery and then, at three months after delivery, completed a questionnaire. The high level of pain experienced was noteworthy. Labour pain and episiotomy pain were uncorrelated, indicating the importance of distinguishing between them. Several women were experiencing problems at the three-month follow-up, with some attributing these to the episiotomy repair. The data are presented in the framework of providing women in the postpartum period with systematic information on the nature of postepisiotomy pain and subsequent recovery to facilitate their adjustment.
Peculiar Focal Myocardial Degeneration and Fatal Ventricular Arrhythmias in a Child
Authors: Wolfgang H. Haese, Barry J. Maron, M. Mirowski, Richard D. Rowe, Grover M. Hutchins
Journal: New England Journal of Medicine (1972)

A 16-month-old child died with ventricular arrhythmias associated with peculiar focal myocardial lesions characterized by myofilament dissolution and mitochondrial hyperplasia.Case ReportA 16-month-old girl (J.H.H. 141 06 28) was in excellent health until a 4-hour episode of rapid pulse, vomiting, cyanosis and pallor occurred. A similar episode occurred 1 week later. An electrocardiogram was interpreted as showing supraventricular tachycardia (rate of 320 per minute). Carotid-sinus massage was unsuccessful, but sinus rhythm was restored 4 hours after intramuscular digoxin (45 μg per kilogram of body weight). On the next day ventricular bigeminy was followed by tachycardia, which responded to 5 . . .
THE OPHTHALMOLOGIST AND THE PSYCHONEUROSES
Authors: LAWRENCE K. LUNT
Journal: JAMA (1924)

The relation between ophthalmology and the functional nervous disorders is obvious to many ophthalmologists. But the fact that we have been invited to discuss it here shows that there is a feeling that perhaps this relationship is not realized in its full importance. This opportunity to emphasize some of the more outstanding features of that relationship is most heartily appreciated. We have occasion to see a very appreciable number of persons whose problem might have been benefited materially by a different method of handling on the part of the specialist in whose hands they have been, so we welcome any chance to contribute to the specialties whatever means we can that will make for better understanding. First, what are the "functional nervous disorders?" They are known as the psychoneuroses or neuroses. More specifically, but entirely inappropriately, they are known as "psychasthenia," "neurasthenia," "nervous exhaustion," "nervous breakdown" or just "nervousness." They
Infant leukaemias and cot deaths.
Authors: A Stewart
Journal: BMJ (1975)

Infant leukaemias differ from childhood leukaemias in ways which suggest that when haemopoietic neoplasms combine fetal origins with rapid growth rates they prevent normal development of the reticuloendothelial system and thus cause the sudden death of apparently healthy babies (stillbirths or cot deaths). Cot deaths are commoner in boys and have a peak incidence during the first half of infancy-that is, during the period most affected by the switch from passive to active immunity. Babies born from July to December, who are intensively exposed to winter conditions form 1 to 5 months of age, are also at special risk. During this period more girls and more children born form January to June die of leukaemia; and within three months of birth an exceptionally high ratio of myeloid to lymphatic leukaemias has been replaced by a low ratio, which persists throughout childhood.
The Colour of the Skin in Human Relations
Authors: Herbert Rattner
Journal: JAMA (1961)

It is not unusual for a dermatologist to concern himself with the subject of skin color. It is unusual, however, for that concern to extend beyond a consideration of biochemical, anatomical, and physiological phenomena into the realm of the role played by skin color in the important field of human relations. In this pocketsized, paper-covered monograph, Simons has packed a wealth of information—a mixture of the historical, philosophical, factual, and conjectural. In an effort to stimulate interest in the long-neglected aspect of the part that skin color plays in human life—in groupings within the human race (racial problem)—he cites the significance of such things as the color bar, shade bar, hair bar, group solidarity, mixed races, caste systems, status symbols, and their resultant cultural and psychological conflicts. Religion, slavery, tattoos, anthropological and ethnological aspects, prejudice, discrimination, and xenophobia are all brought into pertinent and related discussion, and the point is
Melanomas arising from naevi and de novo melanomas ? does origin matter?
Authors: S.C. Weatherhead, M. Haniffa, C.M. Lawrence
Journal: British Journal of Dermatology (2006)

It is widely accepted that some melanomas arise from pre-existing naevi, while others appear de novo. The proportions involved and the effect of melanoma origin on prognosis is unclear.To determine whether melanomas reported by the patient to have developed from a pre-existing naevus are associated with a better or worse prognosis compared with those arising de novo when adjusted for confounding variables.All patients attending a dedicated melanoma screening clinic between March 1997 and March 2002 were included. The distinction between melanoma arising without any pre-existing lesion (de novo) and those derived from a pre-existing lesion (naevus melanoma) was based on patient history. We categorized patients into three groups: those who gave a history of their lesion arising within a pre-existing naevus, those in whom the melanoma developed de novo and those in whom no conclusive history could be obtained. We compared prognostic indicators between the naevus and de novo melanoma groups.Of 8593 patients screened, 377 had a positive diagnosis of melanoma (in situ or invasive). Of these 42% had naevus melanomas, 34% new melanomas and 24% were uncertain. Patients presenting with a melanoma arising from a pre-existing naevus had a greater Breslow thickness despite presenting sooner than the de novo group, although no significant difference in thickness was found when other prognostic factors were controlled for.This prospective study shows that naevi that undergo malignant change may result in melanomas that are thicker and thus potentially have a worse prognosis than de novo melanomas. Although our results were not statistically significant when other risk factors were also taken into account, it is possible that a larger study would identify a significant association.
Manic-Depressive Illness
Authors: Ronald R. Fieve
Journal: JAMA (1970)

If one can agree to these authors' broad definition of affective disorder, one cannot fail to be impressed with their finding that affective disorders occur three times as frequently as schizophrenia in the general population. The authors comprehensively review the diverse findings of epidemiological surveys and studies subclassifying the affective disorders. They question the biological validity of depressive symptom-clusters obtained by factor analytic techniques and conclude that, as yet, the clinical picture and predisposing psychological factors have not resulted in any clear-cut separation of depressive subtypes from the larger group of patients with affective symptoms. An important point of the book— that use of genetic factors is the most promising approach in differentiating out affective subgroups—is supported by the authors' own family history and family study data. In their patient sample, the occurrence of mania and genetic history showing two generations of affective disorder differentiate out one group of patients,
Subacute Oedematous Nephritis Treated with Malaria
Authors: R. Porter
Journal: BMJ (1954)

PREMEDICATION FOR TONSILLECTOMY MEDICALJOHRNAL not occur.Because reflexes and respiration were not depressed it was considered that post-operative nepenthe could safely be administered.Bourne (1954) noted amnesia among patients who received methylpentynol in labour.It was hoped that in this series an amnesic effect might be observed, or at least that the patient's recollection might be pleasant.However, a strong impression emerged, as a result of questioning by a health visitor after their discharge home, that many of the children retained a vivid and unpleasant recollection of the application of the mask or of the prick of the thiopentone injection.Three children who, without the anaesthetist knowing their identity, received a specially prepared "inert" elixir from which the methylpentynol had been omitted, were frightened and crying.They were so different from the majority of oblivon-premedicated children that it was clear that methylpentvnol itself was the effective constituent in the oblivon elixir.Assessment of the Value of Methylpentynol Ideally, premedication for tonsillectomy would be pleasant to receive, easy to administer, would induce sleep without restlessness or loss of muscle tone, and might have further advantages, such as analgesic, amnesic, or anti-emetic properties.It would be non-toxic and would not depress respiration or the protective laryngeal or cough reflexes.Oblivon elixir was pleasant to take and easy to adminis- ter.It seldom induced sleep, but rather a calm and happy frame of mind that seemed to justify the description " anti- jitter drug" used by the popular press.Muscle tone was unaffected.Pre-operative restlessness following the premedication was entirely absent.No undesirable effects were observed apart from vomiting, which was projectile and was accompanied by an active protective reflex as if the premedication had been atropine alone.Respiration was not depressed.Methylpentynol fell short of the ideal in the following wax's.Most children were not asleep, amnesia did not occur, and therefore the patients were conscious of and remembered the induction, which they did not like.Also, they saw what went on in the ward.Of the 152 children, 22 were unhappy.Vomiting was not unusual during the
Patients with cancer denied best treatment
Authors: A. Ferriman
Journal: BMJ (1998)

Only one in five women with ovarian cancer is getting optimal treatment, a new survey from the charity CancerBACUP, reveals. Despite two reports this year from cancer specialists recommending that women be given a combination of paclitaxel and a platinum compound, few health authorities have agreed to fund the combination.

CancerBACUP's survey, which was conducted in July and August 1998, found that 48 of the 60 health authorities surveyed were not committed to providing that combination of drugs.

The survey was conducted before the Joint Council for Clinical Oncology announced their …
Nebulised corticosteroid and amphotericin B: an alternative treatment for ABPA?
Authors: Y. Laoudi, J-B. Paolini, A. Grimfed, J. Just
Journal: European Respiratory Journal (2008)

To the Editors: 

Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disease that results from a hypersensitivity response to Aspergillus fumigatus 1. It occurs in asthmatic and cystic fibrosis (CF) patients, with a prevalence among CF patients recently estimated at 7.8% 1. The natural course is characterised by acute exacerbations, which can be life-threatening 2, and progressive, irreversible, lung damage leading to long-term pulmonary fibrosis if the disease is not well controlled 1.

Therapy for ABPA has two main targets. The first is the attenuation of the inflammation and immunological activity, for which oral corticosteroids are the mainstay of therapy 1. The second is the attenuation of the antigen burden arising from fungal colonisation of the bronchial tree, for which only itraconazole has shown limited evidence of its usefulness 1. However, long-term systemic corticotherapy predisposes to diabetes, osteopaenia, infections and growth retardation, especially in patients with CF, while itraconazole is associated with several drug interactions, suppression of adrenal …
Noninvasive assessment of left anterior descending artery coronary flow reserve by transthoracic echocardiography: feasibility and results
Authors: Fausto Rigo, Walter Curtaia, Claudio Zanella, Pietro Nicolin, Paolo Della Valentina, Lorenza Pratali, Attila Palinkas, Alberto Raviele, Eugenio Picano
Journal: Journal of the American College of Cardiology (2002)
Congenital malalignment of the left index fingernail
Authors: S.C. Murray, R.P.R. Dawber, N. Khumalo
Journal: British Journal of Dermatology (2001)

Journal Article Congenital malalignment of the left index fingernail Get access S.C. Murray, S.C. Murray Department of Dermatology, The Oxford Radcliffe Hospital, Old Road, Headington, Oxford OX3 7LJ, U.K. Search for other works by this author on: Oxford Academic Google Scholar R.P.R. Dawber, R.P.R. Dawber Department of Dermatology, The Oxford Radcliffe Hospital, Old Road, Headington, Oxford OX3 7LJ, U.K. Search for other works by this author on: Oxford Academic Google Scholar N. Khumalo N. Khumalo Department of Dermatology, The Oxford Radcliffe Hospital, Old Road, Headington, Oxford OX3 7LJ, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 144, Issue 4, 1 April 2001, Pages 911–912, https://doi.org/10.1046/j.1365-2133.2001.04162.x Published: 01 April 2001
Imatinib as a Possible Cause of Severe Rhabdomyolysis
Authors: Nicolas Penel, Jean-Yves Blay, Antoine Adenis
Journal: New England Journal of Medicine (2008)

To the Editor: Imatinib mesylate (Gleevec [Glivec], Novartis), a protein kinase inhibitor of c-kit receptor tyrosine kinase (KIT) and platelet-derived growth factor receptor α (PGFR-α), is widely u...
Polysaccharide encapsulated bacterial infection in sickle cell anemia: A thirty year epidemiologic experience
Authors: Wing Yen Wong, Darleen R. Powars, Linda Chan, Alan Hiti, Cage Johnson, Gary Overturf
Journal: American Journal of Hematology (1992)

Abstract Annual age‐specific incidence rates of Streptococcus pneumoniae or Haemophilus influenzae bacterial septicemia in sickle cell anemia (SS) were determined for the years of 1957 through 1989. Forty‐nine patients had 64 episodes of septicemia among a population of 786 SS patients observed for 8,138 person‐years. Peak frequency of infection occurred between 1968‐1971 and 1975‐1981 with a conspicuous absence of episodes in 1972, 1973, 1982‐1984, and 1986‐1987, thus demonstrating cycles of high and low attack rates. The annual age‐specific incidence rate of septicemia varied from 64.5 (1965) to 421.1 (1980) per 1,000 person‐years for those under 2 years of age and never exceeded 10.2 per 1,000 in those over 4 years of age. Following the introduction of pneumococcal polyvalent vaccine in 1978, incidence of infection decreased in SS children greater than 2 years of age. No modification of the risk of infection was observed in immunized children less than 2 years of age. During these three decades, there has been a ten‐fold increase in the number of SS adults over 20 years of age. The relative risk of chronic sickle complications comparing the survivors of septicemia to the non‐infected patients was: subsequent death 1.76, retinopathy 4.06, avascular necrosis 1.95, symptomatic cholelithiasis 1.33, stroke 1.30, and priapsim 1.26. These data suggest that prognosis for lifetime severe SS is initially manifested as an increased risk of septicemia during childhood.