tbuckley/cabot-search huggingface dataset:
Manual of Patient Care in Vascular Surgery
Authors: Carl E. Bredenberg
Journal: JAMA (1983)

This is a good book. It is intended primarily for students, residents, and nurses and addresses the common vascular problems seen in a general hospital without attempting to be an encyclopedic catalogue, achieving its stated goal well. The book is in paperback with spiral binding and is one of the publishers' series of Manuals deriving from the classic Washington UniversityManual of Medical Therapeutics.  The book emphasizes atherosclerotic occlusive disease in its variety of anatomic locations and arterial aneurysms. Vasospastic disorders are briefly but succinctly covered. Discussion of venous problems is usefully limited to varicose veins, postphlebitic syndrome, and venous thromboembolism. Clinical patient assessment, noninvasive laboratory investigation, and perioperative management are handled in direct, practical fashion. The book is practical in its orientation. It identifies those areas that are controversial and in general takes a well-balanced, middle-of-the-road approach. Short but useful bibliographies accompany each chapter.  The authors have succeeded in
The Rotterdam Port Demonstration Centre
Authors: A. Lührs
Journal: New England Journal of Medicine (1954)

IT is common knowledge that in recent years rapid strides have been made in the fight against venereal diseases, especially as a result of new remedies, including the antibiotics. For another reason the number of cases of infection is smaller today than formerly. Recourse to prostitutes — formerly looked upon as a normal procedure in certain sections of the community — is nowadays disapproved, at least in this part of the world.This development, however, must not lead to an overoptimistic judgment. As recently reported, a number of the members of the American Academy of Dermatology and Syphilology, who met . . .
Why can't we all just get along? Integration needs more than stories
Authors: Gordon M. Burghardt, Gregory L. Stuart, Ryan C. Shorey
Journal: Behavioral and Brain Sciences (2014)

As astutely noted by the authors of this provocative article, it is time for evolutionary psychology (EP) to be incorporated into clinical and educational interventions. However, two issues from this article are raised in the current commentary: some historical misconceptions of the evolutionary label and a lack of clear and specific guidelines for developing or improving interventions based on EP.
Heart Transplantation: The Present Status of Orthotopic and Heterotopic Heart Transplantation
Authors: Robert B. Karp
Journal: JAMA (1985)

The editors review the status of cardiac transplantation mainly as practiced at the Groote Schuur Hospital and the University of Cape Town Medical School. The contributors are all members of the staff of the Groote Schuur Hospital, and this leads to both the advantages and some disadvantages of this publication. The information on the development and history of cardiac transplantation is especially useful and interesting. The book contains useful and well-accepted information on the indications and contraindications for cardiac transplantation, the selection and management of the donor, and the surgical technique. The book stresses heterotopic transplantation, however, at the expense of reviewing information and outcome on the more commonly practiced technique of orthotopic transplantation. Cyclosporine A is commonly used as the main immunosuppressive agent in most institutions. Physicians looking for information on its use (and abuse) will not find it in this publication. As a matter of fact, the book
Functional interplay between endothelial nitric oxide synthase and membrane type 1–matrix metalloproteinase in migrating endothelial cells
Authors: Laura Genís, Pilar Gonzalo, Antonio S. Tutor, Beatriz G. Gálvez, Antonio Martínez-Ruiz, Carlos Zaragoza, Santiago Lamas, Karl Tryggvason, Suneel S. Apte, Alicia G. Arroyo
Journal: Blood (2007)
The Optimal Rebiopsy Prostatic Scheme Depends on Patient Clinical Characteristics: Results of a Recursive Partitioning Analysis Based on a 24-Core Systematic Scheme
Authors: Vincenzo Scattoni, Marco Raber, Umberto Capitanio, Firas Abdollah, Marco Roscigno, Diego Angiolilli, Carmen Maccagnano, Andrea Gallina, Antonio Saccà, Massimo Freschi, Claudio Doglioni, Patrizio Rigatti, Francesco Montorsi
Journal: European Urology (2011)
HELIOTHERAPY IN THE TREATMENT OF GENITO-URINARY TUBERCULOSIS
Authors: NELSON A. MYLL
Journal: JAMA (1924)

Tuberculosis of the genito-urinary tract, while not a common disease, occurs frequently enough as a complication of generalized tuberculosis to warrant the serious consideration of the profession. To the physician who is called on to treat a case, realizing, as he does, that it is a condition in which treatment has been far from uniformly successful and for the most part merely temporary and palliative, I hope I have something of value to offer. Before outlining our treatment, at the Fitzsimons General Hospital, for genito-urinary tuberculosis, a brief review of the literature will be given and also our reasons for employing strictly medical procedures, the principle one of which is heliotherapy. Compared with other diseases, genito-urinary tuberculosis is conceded very little space or attention. In medical works this is explainable by the reason that the condition is not considered amenable to medical treatment, and only enough mention is made to
Organ transplant recipients and skin cancer: assessment of risk factors with focus on sun exposure
Authors: D. Terhorst, U. Drecoll, E. Stockfleth, C. Ulrich
Journal: British Journal of Dermatology (2009)

Organ transplant recipients (OTRs) have an increased risk of developing skin cancer, especially epithelial tumours. A number of factors such as immunosuppression, age, ultraviolet radiation and skin type are considered as important in aetiology.The purpose of this study was to further evaluate the risk factors for OTRs regarding skin cancer after transplantation. A detailed investigation of the specific compounds of sun exposure was realised.A questionnaire-based study was performed in a specialist OTR dermatology clinic from January to April 2009. The subjects were 70 organ transplanted patients who had developed some form of skin cancer after transplantation. As controls served 69 organ transplanted patients who had no history of skin cancer. The controls were matched concerning age, transplanted organ and gender. Photo protection, sun exposure and transplantation data were part of the questionnaire. Statistical analysis was performed with Mann-Whitney-U-test, chi-square test or Fisher's exact test.The total sun burden (TSB) and the recreational sun exposure in particular attained higher scores in the skin cancer group (TSB-score: mean 11.8 vs. 10.0, P<0.05; recreational sun exposure: mean 6.3 vs. 5.1, P<0.05). The skin cancer group had fairer skin types than the control group (median skin type 2 vs. 3, P<0.05). The OTRs who developed skin cancer have been more likely to have a history or present intake of azathioprine (mean 42% vs. 21%, P<0.05). Also, the skin cancer group has been transplanted for a longer time (mean 12.3 vs. 7.2 years, P<0.001), analogously had a younger age at transplantation (mean 49.5 vs. 52.7 years, P<0.001).Recreational sun exposure is of central importance for OTRs. A long period of transplantation and thus immunosuppression presents a main risk factor for the development of skin cancer in OTRs. A multi disciplinary management with the best medication and a focus on sun protection is needed to prevent skin cancer in OTRs.
Women and Prenatal Testing: Facing the Challenges of Genetic Technology
Authors: Jane E. Hodgson
Journal: JAMA (1995)

This book is important, even though it offers little new information and few conclusions. Its importance lies in the challenges raised regarding the implications of prenatal genetic testing, the Human Genome Project, and what that new technology means for women today and in the future. Numerous red flags are unfurled throughout its pages as cautionary warnings of the advance of technology. Who will control the production of this new knowledge? Who will interpret the findings? Who will decide what actions are to be taken? Should prenatal testing be compulsory or voluntary? And most important of all, is there a known and predictable quality of life that is associated with specific birth defects or genetic disorders? Such questions led to the conference "Women and the Human Genome Project" in November 1991 on the campus of the National Institutes of Health, cosponsored by the National Institute of Child Health and Human Development,
Multiple Metabolic Syndrome Is Associated With Lower Heart Rate Variability: The Atherosclerosis Risk in Communities Study
Authors: Duanping Liao, Richard P Sloan, Wayne E Cascio, Aaron R Folsom, Angela D Liese, Gregory W Evans, Jianwen Cai, A Richey Sharrett
Journal: Diabetes Care (1998)

OBJECTIVE To test at the population level whether people with multiple metabolic syndrome (MMS) disorders have reduced cardiac autonomic activity (CAA). RESEARCH DESIGN AND METHODS We examined the association between the level of CAA and MMS disorders, at the degree of clustering and the segregate combination levels, using a random sample of 2,359 men and women aged 45–64 years from the biracial, population-based Atherosclerosis Risk in Communities (AR1C) Study. Supine resting 2-min beat-to-beat heart rate data were collected. High-frequency (HF) (0.15–0.35 Hz) and low-frequency (LF) (0.025–0.15 Hz) spectral powers, the ratio of LF to HF, and the SD of all normal R-R intervals (SDNN) were used as the conventional indices of heart rate variability (HRV) to measure CAA. The MMS disorders included hypertension, type 2 diabetes, and dyslipidemia. RESULTS HRV indices were significantly lower in individuals with MMS disorders. The multivariable adjusted mean HF was 0.85 (beat/min)2 in subjects with all three MMS disorders, in contrast to 1.31 beat/min)2 in subjects without any MMS disorder. At the segregated combination level, the multivariable adjusted means ± SEM of HF were 1.34 ± 0.05, 1.16 ± 0.05, 1.01 ± 0.17, and 1.34 ± 0.05 (beat/min)2, respectively, for subjects without any MMS disorder, with hypertension only, with diabetes only, and with dyslipidemia only, and the means ± SEM of HF were 0.93 ± 0.04,0.70 ± 0.15, and 1.20 ± 0.05 eat/min)2, respectively, for subjects with diabetes and hypertension, diabetes and dyslipidemia, and hypertension and dyslipidemia. An increase in fasting insulin of 1 SD was associated with 88% higher odds of having a lower HF The pattern of associations was similar for LF and SDNN. CONCLUSIONS These findings suggest that MMS disorders adversely affect cardiac autonomic control and a reduced cardiac autonomic control may contribute to the increased risk of subsequent cardiovascular events in individuals who exhibit MMS disorders.
The use of a synthetic oxygen carrier-enriched hydrogel to enhance mesenchymal stem cell-based bone formation in vivo
Authors: Nadav Kimelman-Bleich, Gadi Pelled, Dima Sheyn, Ilan Kallai, Yoram Zilberman, Olga Mizrahi, Yamit Tal, Wafa Tawackoli, Zulma Gazit, Dan Gazit
Journal: Biomaterials (2009)
Maps versus clusters: different representations of auditory space in the midbrain and forebrain
Authors: Yale E. Cohen, Eric I. Knudsen
Journal: Trends in Neurosciences (1999)

The auditory system determines the location of stimuli based on the evaluation of specific cues. The analysis begins in the tonotopic pathway, where these cues are processed in parallel, frequency-specific channels. This frequency-specific information is processed further in the midbrain and in the forebrain by specialized, space-processing pathways that integrate information across frequency channels, creating high-order neurons tuned to specific locations in space. Remarkably, the results of this integrative step are represented very differently in the midbrain and forebrain: in the midbrain, space is represented in maps, whereas, in the forebrain, space is represented in clusters of similarly tuned neurons. We propose that these different representations reflect the different roles that these two brain areas have in guiding behavior.
Cancer in patients on dialysis for end-stage renal disease: an international collaborative study
Authors: Patrick Maisonneuve, Lawrence Agodoa, Ryszard Gellert, John H Stewart, Gheardo Buccianti, Albert B Lowenfels, Robert A Wolf, Elisabeth Jones, Alex PS Dsiney, Douglas Briggs, Margaret McCredie, Peter Boyle
Journal: The Lancet (1999)
A randomised placebo controlled trial of delipidated, deglycolipidated Mycobacterium vaccae as immunotherapy for psoriatic arthritis
Authors: N Dalbeth
Journal: Annals of the Rheumatic Diseases (2004)

<b>Objectives:</b> To test the hypothesis that PVAC, delipidated, deglycolipidated heat killed <i>Mycobacterium vaccae</i>, is an effective and safe treatment for psoriatic arthritis (PsA). This treatment has shown promising results in psoriasis. <b>Methods:</b> 36 patients with PsA in two centres were studied in this double blind, placebo controlled, randomised trial. Patients were randomised to receive two intradermal injections of 50 µg PVAC or placebo and were followed up for 24 weeks. The primary end point was the Psoriatic Arthritis Response Criteria (PsARC), a composite measure based on changes in joint tenderness and swelling scores and physician and patient global assessments. <b>Results:</b> The PsARC response at either 12 or 24 weeks was achieved by 9/18 (50%) placebo and 9/18 (50%) PVAC patients (p = 1.0). No significant differences in the Psoriasis Activity and Severity Index (PASI), patient or physician global assessments, CRP, or Health Assessment Questionnaire score over time were found between the two groups. However, changes in the pain visual analogue scale over time did differ between the two groups (p = 0.006): at 24 weeks the mean score in the PVAC group had declined by 19.2 mm and in the placebo group had increased by 4.8 mm. PVAC was well tolerated with no increased incidence of adverse events compared with placebo. <b>Conclusions:</b> PVAC was not shown to be as effective as immunotherapy for PsA. The striking response to placebo in this study reinforces the importance of adequately controlling therapeutic trials in PsA.
TIME COURSE OF LEFT VENTRICULAR FUNCTION IN PATIENTS WITH IMPAIRED LEFT VENTRICULAR EJECTION FRACTION AFTER ACUTE MYOCARDIAL INFARCTION
Authors: Georgette E. Hoogslag, M. Louisa Antoni, Victoria Delgado, Helèn Boden, Eduard R. Holman, Ernst E. van der Wall, Martin J. Schalij, Jeroen J. Bax
Journal: Journal of the American College of Cardiology (2011)
Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach
Authors: Crystal A. Gadegbeku, Debbie S. Gipson, Lawrence B. Holzman, Akinlolu O. Ojo, Peter X.K. Song, Laura Barisoni, Matthew G. Sampson, Jeffrey B. Kopp, Kevin V. Lemley, Peter J. Nelson, Chrysta C. Lienczewski, Sharon G. Adler, Gerald B. Appel, Daniel C. Cattran, Michael J. Choi, Gabriel Contreras, Katherine M. Dell, Fernando C. Fervenza, Keisha L. Gibson, Larry A. Greenbaum, Joel D. Hernandez, Stephen M. Hewitt, Sangeeta R. Hingorani, Michelle Hladunewich, Marie C. Hogan, Susan L. Hogan, Frederick J. Kaskel, John C. Lieske, Kevin E.C. Meyers, Patrick H. Nachman, Cynthia C. Nast, Alicia M. Neu, Heather N. Reich, John R. Sedor, Christine B. Sethna, Howard Trachtman, Katherine R. Tuttle, Olga Zhdanova, Gastòn E. Zilleruelo, Matthias Kretzler
Journal: Kidney International (2013)
Switch to soy protein for boring but healthful diet
Authors: William A. Check
Journal: JAMA (1982)

Physicians attempting to alter the blood lipid levels of their patients might look to a new form of control: increasing the proportion of plant protein in the diet. Two reports at the recent meeting of the American Institute of Nutrition in New Orleans showed that substituting plant protein for animal protein in the diets of healthy, normal volunteers had beneficial effects on blood lipid levels in short-term trials, even though the lipid component of the diet was not altered. The different degrees of change seen in the two studies may reflect the different proportions of plant protein in the respective diets. Those of us raised with the contemporary emphasis on reducing dietary fats and cholesterol might be surprised to learn that the first explanation of atherogenesis focused primarily on protein. In 1909, the Russian physician and physiologist A. Ignatowski postulated that the clearest explanation for the high incidence of heart
In vivo real-time imaging of human duodenal mucosal structures in celiac disease using endocytoscopy
Authors: T. Matysiak-Budnik, E. Coron, J.-F. Mosnier, M. Le Rhun, H. Inoue, J.-P. Galmiche
Journal: Endoscopy (2010)

Celiac disease is a gluten-induced enteropathy whose diagnosis is based on histological evidence of villous atrophy. The diagnosis may be difficult if the orientation of histological sections is other than optimal. During upper gastrointestinal endoscopy we studied in vivo duodenal mucosa in patients with celiac disease using endocytoscopy, a novel diagnostic technique allowing in vivo real-time visualization of mucosa under x 450 magnification.Sixteen patients with documented celiac disease and seven controls without celiac disease were studied. Endocytoscopic images obtained from several fields were compared in a blinded fashion to standard histology.Endocytoscopy showed three different patterns of in vivo histology: (1) the presence of normal-appearing, long, thin villi, lined with clearly distinguishable surface epithelial cells, considered to be normal duodenal mucosa (n = 15, all controls and eight celiac disease patients); (2) the presence of thick, shortened villi, reflecting partial villous atrophy (n = 4); and (3) the total absence of villi and the presence of enlarged crypt orifices, reflecting total villous atrophy (n = 4). Good concordance between endocytoscopy and standard histology was found in all 16 patients with celiac disease.Endocytoscopy allows in vivo, real-time, noninvasive visualization and characterization of villous architecture and may be a promising method for in vivo evaluation of duodenal mucosa in celiac disease.
Prevalence of Hypertension and Associated Risk Factors Among Diabetic Individuals: The Three-City Study
Authors: J Michael Sprafka, Alan P Bender, Helen G Jagger
Journal: Diabetes Care (1988)

A cross-sectional study was conducted from 1979 through 1982 in three rural Minnesota cities to describe the natural history of diabetes mellitus. Detailed abstracts of the medical records of physician-defined diabetic individuals were used to construct medical profiles. As part of the effort, the date of physiciandefined hypertension was identified and used to calculate hypertension prevalence. The crude hypertension prevalence was 56.8% for women and 33.99% for men, with an overall crude prevalence of 47.2%. No hypertensive patients were identified among diabetic patients &amp;lt;15 yr old, and most hypertensive diabetic patients were &amp;gt;70 yr old. Hypertension prevalence in diabetic individuals demonstrated a highly significant trend with age (P &amp;lt; .01). Compared with the general population, diabetic individuals had a significantly higher prevalence of hypertension (P &amp;lt; .01), largely explained by the higher prevalence in women. Variables known to be associated with hypertension risk in the general population were also significantly associated with hypertension among diabetic individuals. Older age, being female, nd increased body mass index were strongly associated with hypertension in this study population. Diabetic individuals with hypertension were six times more likely to have renal disease than those without hypertension.
Transgastric Peritoneoscopy versus Laparoscopy for the Detection of Peritoneal Metastases
Authors: RP Voermans, M Van Berge Henegouwen, S Conlon, J Spivey, R Rowe, B Sheppard, P Fockens, D Faigel
Journal: Endoscopy (2008)

Background: If Natural Orifice Transluminal Endoscopic Surgery (NOTES) peritoneoscopy is to become an alternative to diagnostic laparoscopy, it must prove to be at least as accurate as the diagnostic laparoscopy (LAP).
Pediatric Rheumatology for the Practitioner
Authors: George E. Ehrlich
Journal: JAMA (1983)

<b>Textbook of Pediatric Rheumatology,</b>by James T. Cassidy, 684 pp, with illus, $47.50, New York, John Wiley &amp; Sons Inc, 1982. Rapid recent developments in rheumatology have demanded new books about rheumatic manifestations in children. The venerable books of Brewer and Grokoest drew attention to the specialty of pediatric rheumatology some years ago and served to excite the interest of pediatricians and internists alike in choosing a subspecialty. In some centers, pediatric rheumatologists provide expertise, in other centers, rheumatologists divide their interests between adult and childhood rheumatic disorders. We are now treated to the almost simultaneous appearance of two new textbooks. One, by Jacobs, is a tour de force in that a single author has written it all. But the other, by Cassidy, is not far behind, as there are only five collaborators, who are given little of the responsibility. Essentially, then, these two books reflect the opinions of the
Skin Findings in a Patient with Scurvy
Authors: C M Kronauer, H Bühler
Journal: New England Journal of Medicine (1995)

Figure 1. The legs of a 46-year-old man with scurvy are shown. The man had a mild mental disorder, and his diet consisted only of bread, pasta, packaged cookies, and water. Large ecchymotic areas extended over the backs of the legs (Panel A). A close-up (Panel B) shows perifollicular hemorrhages and hyperkeratotic papules in which hair is fragmented and buried. The plasma ascorbic acid concentration was 0.11 mg per deciliter (6.25 μmol per liter; normal concentration, >0.62 mg per deciliter [35 μmol per liter]) after three days of a hospital diet. With a normal diet and vitamin C replacement therapy . . .
The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages
Authors: Liliana Schaefer, Andrea Babelova, Eva Kiss, Heinz-J. Hausser, Martina Baliova, Miroslava Krzyzankova, Gunther Marsche, Marian F. Young, Daniel Mihalik, Martin Götte, Ernst Malle, Roland M. Schaefer, Hermann-Josef Gröne
Journal: Journal of Clinical Investigation (2005)

Biglycan, a small leucine-rich proteoglycan, is a ubiquitous ECM component; however, its biological role has not been elucidated in detail. Here we show that biglycan acts in macrophages as an endogenous ligand of TLR4 and TLR2, which mediate innate immunity, leading to rapid activation of p38, ERK, and NF-κB and thereby stimulating the expression of TNF-α and macrophage inflammatory protein–2 (MIP-2). In agreement, the stimulatory effects of biglycan are significantly reduced in TLR4-mutant (TLR4-M), TLR2–/–, and myeloid differentiation factor 88–/– (MyD88–/–) macrophages and completely abolished in TLR2–/–/TLR4-M macrophages. Biglycan-null mice have a considerable survival benefit in LPS- or zymosan-induced sepsis due to lower levels of circulating TNF-α and reduced infiltration of mononuclear cells in the lung, which cause less end-organ damage. Importantly, when stimulated by LPS-induced proinflammatory factors, macrophages themselves are able to synthesize biglycan. Thus, biglycan, upon release from the ECM or from macrophages, can boost inflammation by signaling through TLR4 and TLR2, thereby enhancing the synthesis of TNF-α and MIP-2. Our results provide evidence for what is, to our knowledge, a novel role of the matrix component biglycan as a signaling molecule and a crucial proinflammatory factor. These findings are potentially relevant for the development of new strategies in the treatment of sepsis.