tbuckley/cabot-search huggingface dataset:
Pediatric Practice Sports Medicine
Authors: Hatim Omar
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vasodilating action of L-dopa.
Authors: E Vaccaro, A Solitro
Journal: BMJ (1972)

There are few reports of acute cerebellar ataxia presenting in adults and it is of in- terest that Brumlik and Means3 describe two American cases showing "lightening eye movements, peculiar shuddering tremor and cerebellar ataxia."It is tempting to postulate that encephalitis tremens, a benign epidemic form of acute cerebellar ataxia with R.I.M.E.L. limited geographically to a region of West Africa rain forest, might represent an abor virus encephalitis involving the brainstem.How- ever, such an assumption awaits investigation.-I am, etc.,
Assessment of non-mydriatic photography in detection of diabetic retinopathy
Authors: H. Cheng, S. Franklin
Journal: BMJ (1986)

measured during this period may be an unreliable marker.For Dr Holt and colleagues to base diagnosis ofcyclosporin nephrotoxicity on only the absence of obstruction or histological signs of rejection seems unsatisfactory; some characteristic histological aspects of nephrotoxicity have been described' that they did not mention.Moreover, the possibility of viral infections that cause renal dysfunction cannot be excluded, mainly in the first weeks after transplantation.There is a discrepancy in the study: although its aim was to investigate the relation between the cause of renal graft dysfunction and trends in predose blood cyclosporin concentrations during the week before the episode of renal dysfunction, the authors considered the cyclosporin concen- trations in the week before biopsy, and the median time between transplantation and graft biopsy was two weeks, whereas that between transplantation and rejection episodes was five weeks.Moreover, the authors do not report the daily cyclosporin dose given in the week before renal biopsy and any changes during this period.They do say that the cyclosporin dose was reduced whenever blood values were over 666 nmol/l (800 ng/ml), and a reduction might in fact favour rejection, thus explaining the occurrence of rejections in some subjects with high cyclosporin values.We believe that details of reproducibility of the method not only at 416 nmol/l (500 ng/ml) but also at the lower and upper ends of the standard curve could usefully have been included, as well as data on a control group of patients with neither toxicity nor rejection and their mean cyclosporin levels.
Medicaid Coverage for Young Women and Children: Whose Welfare Is at Stake?
Authors: Edgar A. Suter
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The Editorial by Dr Swartz<sup>1</sup>exhorted us, "We need to ensure adequate funding of Medicaid programs for children or we need to find another way to provide health insurance to young women and children." We need no such things. What we need to do is examine the unspoken assumptions of such exhortations, to examine the immoral assumptions of those who would take our money from our families to give to others. Apparently, at least part of Swartz's job at her academic bureaucracy is to promote more funding not only for the poor but presumably also for more academic bureaucracy. Funding such investments leaves my household and millions of other households of other working taxpayers with less money. Are not the funding of my son's household, my son's health care, and my son's education important? Are not the other working households at least as important as the households of those
Asymptomatic and Significant Bacteriuria
Authors: N. B. Eastwood
Journal: BMJ (1965)

It was unnecessary for Professor Conn to select cases of primary aldosteronism from our published results,68 since we had reported these conclusions in the same group of cases -in Professor Conn's presence-more than a year before.8Professor Milne's case was not one of these.Our recent paper9 was a pro- gress report on a patient described in some detail earlier.6 We said of this case in 1963 that the association of low plasma-renin concentration and increased aldosterone secretion suggested an aldosterone-producing adrenal tumour, and that we were studying the effects of spironolactone treatment before removing the tumour.'It thus seems obtuse of Professor Conn to misconstrue2 the intention of our paper' as " final proof " of his more recent " thesis."We should further make it clear that neither we nor Professor Conn and his colleagues can rightly claim priority for the prediction of low plasma renin in primary aldosteronism, or for the removal of a tumour from a patient investigated in this way.Any such credit belongs to others.0"-We are, etc.,
BIOLOGICAL AND CLINICAL ASPECTS OF HEMATOPOIETIC STEM CELLS
Authors: Gerald J. Spangrude, Ph.D
Journal: Annual Review of Medicine (1994)

▪ Abstract Recent advances in cell isolation techniques have greatly enhanced our understanding of the phenotype and function of hematopoietic stem cells in mice and humans. Many clinical studies have established the efficacy of using peripheral blood stem cells to supplement or replace bone marrow transplantation as a therapeutic modality for several types of malignancies. This new approach to malignant disease management, perhaps in combination with posttransplantation cytokine therapy, promises to completely alter the clinical course of bone marrow transplantation.
Home office loses appeal over legality of fast track deportation without legal counsel
Authors: C. Dyer
Journal: BMJ (2011)

UK government policy of “fast-track” deportation for some migrants, including some unaccompanied minors, with less than 72 hours notice is unlawful, the Court of Appeal has ruled.

Three appeal court judges dismissed the Home Office’s appeal from a high court judgment last year in a challenge by the charity Medical Justice to UK Border Agency (UKBA) policy adopted in January 2010 allowing removal on short notice in some cases. The cases included unaccompanied minors at risk of absconding, those where notification might create a suicide risk …
Care and outcomes in young adults with type 1 diabetes: More laser treatment is used in England than the Netherlands
Authors: D. J Kinshuck
Journal: BMJ (2003)

Editor—Wills et al retrospectively reviewed care and outcomes in young adults with type 1 diabetes.1 I audited this hospital's results and compared them with those of a colleague in the Netherlands (table). My findings were similar to those of Wills et al, although the data were not as accurate as theirs.1 Our patients seem to need a lot more laser treatment. Our results are better or equal to those in the rest of Birmingham, even taking into account that the hospital is in a comparatively wealthy area.



Table 1

Audit and comparison of data from diabetes clinics in the Netherlands and England, 2002 (with some changes since)



The reason for poor care in diabetes in the United Kingdom may be cultural, affecting both patients and professionals in accepting high glucose concentrations, etc, and organisational. Patients who do not attend are often left to their own devices, for example. But much of the reason must be down to resources. For every 1333 adult patients with diabetes we have one diabetes specialist nurse while our Dutch colleague has one diabetes specialist nurse for every 365 patients. Similarly, his patients certainly have much better access to insulin pumps (about 40% of patients with type 1 diabetes).

Although glargine has improved matters by helping patients to achieve good control, our diabetes team has not been successful in obtaining funding for more diabetes specialist nurses despite having tried its own management, the local primary care trust or strategic health authority, and the Department of Health. I imagine that this is because, politically, diabetes has a low profile.
Fifty Years of Clinical Research by the Leukemia Committee of the Cancer and Leukemia Group B
Authors: Richard A. Larson, Richard M. Stone, Robert J. Mayer, Charles A. Schiffer
Journal: Clinical Cancer Research (2006)

Abstract Progress in the care of patients with leukemia has been one of the great success stories in the field of oncology, and clinical research in leukemia has been the “flagship” of the Cancer and Leukemia Group B since the inception of this organization. Lessons learned from the founders' emphasis on childhood and adult leukemia have been extended broadly over the past 50 years to virtually all types of malignant diseases, and the Leukemia Committee has continued to provide leadership and key contributions. The Leukemia Committee is focused on the individualization of treatment based on distinctive biological and clinical characteristics with the aim of increasing efficacy and decreasing nonspecific toxicity. Our clinical trials in leukemia and myeloma have shifted from primarily empirically derived comparisons of different chemotherapeutic regimens to testing novel concepts such as the role of dose intensity, inhibition of specific mechanisms of drug resistance, the use of hematopoietic growth factors and monoclonal antibodies, and the utility of targeted agents. The Cancer and Leukemia Group B was the pioneer among the cooperative groups in the creation of centralized tissue repositories and the incorporation of correlative laboratory studies as an integral feature of clinical trials, a practice now termed “translational research.” Considerable effort has focused on the identification of important pretreatment characteristics, such as morphologic features, immunophenotype, chromosomal abnormalities, and molecular defects, which are significantly associated with outcome in multivariable analyses and which enhance our understanding for the complex biology of these diseases.
Are ribbon campaigns making us loopy?
Authors: Michael Fitzpatrick
Journal: BMJ (2004)

At the start of ovarian cancer awareness month, a general practitioner claims that disease awareness increases anxiety—and newspaper and magazine circulations—much more than it increases diagnosis 

“And finally, today is colorectal cancer awareness day so here's our health correspondent—wearing the campaign's distinctive melaena-coloured ribbon—to tell us about a new ‘do-it-yourself’ colonoscopy technique.”

Perhaps not this week, but it can only be a matter of time before every day of the year is allocated to some disease or disorder and every news bulletin concludes with an awareness raising feature. But when does public enlightenment become morbid preoccupation? Are we in danger of becoming so obsessed with the threat of disease that our quality of life is diminished?

   ![][1] 

Powerful forces drive campaigns to increase public recognition of disease. Doctors seeking to raise the profile of their specialty or special interest sponsor voluntary organisations to attract funds and promote research. For politicians worried about their loss of influence and respect, health …

 [1]: /embed/graphic-1.gif
Human Rhinovirus Precipitates Acute Wheezing, Preferentially Over Upper Respiratory Illness, in School-aged Children With Underlying Asthma
Authors: J.A. Zea-Hernandez, N. Bhat, M.E. Serra, Y. Mohamed, D. Kraft, A. Chen, G.K. Siberry, B.E. Shepherd, E.K. Miller, F.P. Polack
Journal: Journal of Allergy and Clinical Immunology (2010)
Websites should specify level of evidence for information they publish, report says
Authors: A. Dorozynski
Journal: BMJ (2002)

In May 2000, the French Ministry of Health and the national medical association decided to assess the quality of health information available on the internet and to define a French code of ethics for health sites.

One of the objectives was to define criteria to assess the quality of information termed “sensitive” because it could influence a decision about the user's health. The main criterion chosen was the level of evidence (“niveau de preuve”) for the statement or claim being …
Points from Letters: An Overpaid Profession?
Authors: C. Taylor
Journal: BMJ (1974)

some extent those retiring between 1969 and 1972 will be given less than their olleagues who retired after 24 March 1972.This means that there has to be for them a different formula from that for general practitioners retiring after 24 March 1972 and it is on this that there have been some-what protracted negotiations with the De- partment.We have certainly put every pressure on the Department to expedite matters and we hope that with the help of our professional expert advisers we -may be able to reach an early settlement."-ED.,
Modulation of Ca2+ cycling in cardiac myocytes by arachidonic acid.
Authors: D S Damron, M Bond
Journal: Circulation Research (1993)

It is believed that inotropic agents exert their effects in cardiac muscle via a modulation of Ca2+ cycling; however, the involvement of phospholipase activation and the biochemical pathways participating in inotropic responsiveness remain unclear. The aim of the current study was to determine whether arachidonic acid and/or eicosanoids participate in inotropic responses by modulating Ca2+ cycling in cardiac myocytes. Experiments were performed with populations of freshly isolated, fura-2-loaded adult rat ventricular myocytes. Arachidonic acid stimulated a transient increase in cytosolic free Ca2+, which was still present after addition of EGTA but was significantly reduced by pretreatment with caffeine. Addition of arachidonic acid to either electrically stimulated or quiescent myocytes enhanced the amplitude of the ATP-induced Ca2+ transient. This effect was still observed in the presence of inhibitors of cyclooxygenase, lipoxygenase, and epoxygenase pathways but was significantly diminished after pretreatment with inhibitors of protein kinase C. In contrast, arachidonic acid attenuated the amplitude of electrically induced Ca2+ transients. This effect was mimicked by eicosatetraynoic acid and by the K+ channel agonist pinacidil. The inhibitory effect of eicosatetraynoic acid and arachidonic acid was reversed by addition of fatty acid-free bovine serum albumin. Together, these results suggest that arachidonic acid may play a physiological role in cardiac muscle excitation-contraction coupling as a modulator of sarcolemmal ion channels and/or Ca2+ release from the sarcoplasmic reticulum.
Obesity is associated with improved survival in community-acquired pneumonia
Authors: Anika Singanayagam, Aran Singanayagam, James D. Chalmers
Journal: European Respiratory Journal (2012)

Obesity has been identified as a risk factor for adverse outcomes of 2009 H1N1 influenza. However, the impact of obesity on outcomes of infection remains controversial. There are limited data investigating the effect of obesity on outcomes of community-acquired pneumonia (CAP). This prospective observational study included patients presenting with CAP who had body mass index (BMI) measured on admission. Outcome measures included 30-day mortality and need for mechanical ventilation or inotropic support (MV/IS). 1079 patients were included, with 21% classified as obese (BMI ≥30 kg·m −2 ). Obesity was independently associated with reduced 30-day mortality from CAP on multivariate analysis (HR 0.53, 95% CI 0.29–0.98). This was not explained by differences in severity of disease on admission or requirement for MV/IS between obese and nonobese groups. Obese patients had higher median C-reactive protein levels and a higher frequency of sepsis using the systemic inflammatory response syndrome criteria (72.4% versus 64.1%; p=0.03), than nonobese patients, suggesting greater systemic inflammation. Obesity was associated with reduced 30-day mortality in patients hospitalised with CAP.
INTERLEUKIN-6 AND GALECTIN-3 ARE LOWER IN PATIENTS WITH HEART FAILURE WHO DO NOT RESPONSE TO EXERCISE TRAINING
Authors: Miguel Morita Fernandes da Silva, Guilherme Guimarães, Marco Lofrano-Alves, Rafael Castro, Lais Cruz, Edimar Bocchi, Fernando Bacal
Journal: Journal of the American College of Cardiology (2015)
Reflex Vascular Responses to Stimulation of Chemoreceptors with Nicotine and Cyanide
Authors: MANUEL G. CALVELO, FRANCOIS M. ABBOUD, DENNIS R. BOLLARD, WADIE ABDEL-SAYED
Journal: Circulation Research (1970)

Experiments were done to characterize the vascular responses to stimulation of aortic and carotid chemoreceptors and to identify the efferent components of the sympathetic system which are activated in different vascular beds. The chemoreceptors were stimulated with nicotine and cyanide in anesthetized and artificially ventilated dogs. The gracilis muscle and hindpaw were isolated and perfused with blood at constant flow. Changes in perfusion pressure reflected changes in total vascular resistance, and changes in small vein pressure reflected changes in venous resistance. The results indicate that stimulation of carotid and aortic chemoreceptors activates selectively efferent adrenergic constrictor fibers supplying prevenous resistance vessels in the gracilis muscle and venous resistance vessels in the paw. In contrast, there was a dilatation of prevenous resistance vessels in the paw caused by activation of efferent sympathetic dilator fibers and not by withdrawal of sympathetic constrictor tone. The dilatation was not mediated through the release of acetylcholine, histamine, or bradykinin nor through beta receptors. Bilateral denervation of the carotid sinus and body and bilateral vagotomy abolished the reflex responses caused by injections of the chemicals. These responses were not the result of activation of baroreceptors since they were not reproduced during electrical stimulation of the carotid sinus nerve.
High frequency of a deletion polymorphism of the angiotensin-converting enzyme gene in asthma
Authors: Joelle Benessiano, Bruno Crestani, Fouzi Mestari, Wassila Klouche, Françoise Neukirch, Salima Hacein-Bey, Genevieve Durand, Michel Aubier
Journal: Journal of Allergy and Clinical Immunology (1997)
NOTES ON THE ADMINISTRATION OF GALLIC ACID, ESPECIALLY IN HAeMOPTYSIS AND IN ALBUMINURIA
Authors: W. T. Gairdner
Journal: BMJ (1855)

QxW+L OOKmmhTIOON3. of t sd. of a guinea-g.In two utes the animal fell on the side stuggling, but without apping to be convulsed, thee being no rigidity of the muscles.In four minutes it ced to breathe, and showed no outward sign of life, except a slight quivering of the lower lip.On examination in five minutes from the commencement of the experiment there was no muscular rigidity.The heart was found filled with blood, and pulsating with a quick, feeble motion, chiefly perceptible in the auricle, as if
Phase II study of autologous mRNA electroporated dendritic cells (TriMixDC-MEL) in combination with Ipilimumab in patients with pretreated advanced melanoma
Authors: Kris Thielemans, Bart Neyns, Sofie Wilgenhof, Jurgen Corthals, Carlo Heirman
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Autologous monocyte-derived mRNA electroporated dendritic cells (TriMixDC-MEL) are immunogenic and have anti-tumor activity in patients (pts) with pretreated advanced melanoma (Wilgenhof S. et al. Ann Oncol. 2013). Ipilimumab (Ipi) is a monoclonal antibody directed against the
Constitutive nuclear factor–κB activity preserves homeostasis of quiescent mature lymphocytes and granulocytes by controlling the expression of distinct Bcl-2 family proteins
Authors: Fabrice Bureau, Alain Vanderplasschen, Fabrice Jaspar, Frédéric Minner, Paul-Pierre Pastoret, Marie-Paule Merville, Vincent Bours, Pierre Lekeux
Journal: Blood (2002)
942-42 Is Mitral Valve Prolapse with Significant Mitral Regurgitation a Different Condition from Uncomplicated Mitral Prolapse? Results of Family Studies
Authors: Alfredo Zuppiroli, Mary J. Roman, Richard B. Devereux, Mariane C. Spitzer, Michael J. O’Grady
Journal: Journal of the American College of Cardiology (1995)
EVALUATION OF THE EFFICACY AND SAFETY OF OTAMIXABAN VS. UNFRACTIONATED HEPARIN+EPTIFIBATIDE IN ELDERLY PATIENTS WITH NON-ST-ELEVATION ACUTE CORONARY SYNDROMES IN THE SEPIA-ACS1 TIMI 42 TRIAL
Authors: Christian T. Ruff, Shaun Goodman, Hanoch Hod, Christoph Bode, Petr Widimsky, Robert G. Kiss, Charles F. Contant, Sharon E. Crugnale, Angele Moryusef, Gabriel Steg, Elliott M. Antman, Marc S. Sabatine
Journal: Journal of the American College of Cardiology (2011)
Most doctors do not think revalidation will identify doctors who aren't fit to practise
Authors: A. Rimmer
Journal: BMJ (2014)

Most UK doctors do not think revalidation will deal with doctors who are not fit to practise, a survey has found.

The results of a survey, reported by the Independent newspaper, showed that 53% of hospital doctors and 60% of GPs did not believe that revalidation would help identify and deal with doctors who were not fit to practise.1 More than 4600 hospital doctors and 1000 …
Cobalt Radiation for Essential Hematuria
Authors: Gordon L. Mathes
Journal: JAMA (1961)

Eight patients with essential unilateral hematuria were treated with 1,500 r of cobalt radiation to the bleeding kidney. Hematuria ceased in 6 patients and became microscopic in the remaining 2. Three were found pyelographically to have a venous calycine channel causing the hematuria, a finding first reported in 1960 by Pytel, a Russian urologist. Surgery, a partial nephrectomy to remove the channel, was necessary in only 1 of the 8 patients. The others responded to irradiation with cobalt-60 and the other conservative measures.
Intraoperative cholangioscopy with an ultrathin endoscope for hemobilia
Authors: M. Aydinli, I. Koruk, S. Koruk, U. Aydin, A. Kadayifci
Journal: Endoscopy (2011)

Hemobilia is a rare but potentially fatal cause of gastrointestinal bleeding [1]. Identifying the source of bleeding may require investigations such as angiography and laparotomy [2].
Modified paediatric resuscitation chart.
Authors: D P Burke, D F Bowden
Journal: BMJ (1993)

OBJECTIVES--To determine whether a modified paediatric resuscitation reference chart improves the speed and accuracy of calculation of doses of drugs in simulated paediatric cardiopulmonary arrests when compared with the chart devised by Oakley. DESIGN--A prospective study in which a series of randomly assigned questions was used to compare the performance of doctors using the two charts. SETTING--Accident and emergency departments in two hospitals. SUBJECTS--31 senior house officers. MAIN OUTCOME MEASURES--The speed and accuracy of calculation of volumes of drugs to be administered. RESULTS--The modified chart significantly increased the accuracy of the calculations (62/62 v 43/62, p &lt; 0.01 [corrected]), the speed of correct calculations (6.8 v 36.0 s, p &lt; 0.0001), and the number of calculations that were completed (62/62 v 50/62, p &lt; 0.001). CONCLUSIONS--The modified paediatric resuscitation chart should supersede the existing chart.
Die Störungen des Lichtreflexes der Pupille bei den Luetischen Erkrankungen des Zentralnervensystems. Beiträge zur Frühdiagnostik der Lues Nervosa. By<i>Otto Löwenstein.</i>(Basel: Benno Schwabe &amp; Co., Verlag, 1935.)
Authors: J. Notkin
Journal: American Journal of Psychiatry (1935)