Screening for Lung Cancer With Low-Dose Computed Tomography
Authors: Linda L. Humphrey, Mark Deffebach, Miranda Pappas, Bernadette Zakher, Christopher G. Slatore
Journal: Annals of Internal Medicine (2014)

Letters4 February 2014Screening for Lung Cancer With Low-Dose Computed TomographyLinda L. Humphrey, MD, MPH, Mark Deffebach, MD, Miranda Pappas, MA, Bernadette Zakher, MBBS, and Christopher G. Slatore, MD, MSLinda L. Humphrey, MD, MPHFrom Portland Veterans Affairs Medical Center, Portland, Oregon; Oregon Health & Science University, Portland, Oregon; and Portland Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this author, Mark Deffebach, MDFrom Portland Veterans Affairs Medical Center, Portland, Oregon; Oregon Health & Science University, Portland, Oregon; and Portland Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this author, Miranda Pappas, MAFrom Portland Veterans Affairs Medical Center, Portland, Oregon; Oregon Health & Science University, Portland, Oregon; and Portland Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this author, Bernadette Zakher, MBBSFrom Portland Veterans Affairs Medical Center, Portland, Oregon; Oregon Health & Science University, Portland, Oregon; and Portland Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this author, and Christopher G. Slatore, MD, MSFrom Portland Veterans Affairs Medical Center, Portland, Oregon; Oregon Health & Science University, Portland, Oregon; and Portland Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5003-3 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:As we noted in our article and the associated systematic review, overdiagnosis is a risk of lung cancer screening of uncertain magnitude. We do not believe that the Mayo Lung Project provides a valid estimate of overdiagnosis for many reasons, most of which we outlined in our report (1) and the prior review (2). More research in this important area is needed.We rated the quality of the DLCST as moderate. Limitations that we identified included a lack of description of allocation concealment, as Drs. Brodersen, Dirksen, and Pedersen note. They state that patients were randomly assigned at ...References1. Humphrey L, Deffebach M, Pappas M, Baumann C, Artis K, Mitchell JP, et al. Screening for Lung Cancer: A Systematic Review to Update the U.S. Preventive Services Task Force Recommendation. Report no. 13-05188-EF-1. Rockville, MD: Agency for Healthcare Research and Quality; 2013. Google Scholar2. Humphrey LL, Teutsch S, Johnson M; U. S. Preventive Services Task Force. Lung cancer screening with sputum cytologic examination, chest radiography, and computed tomography: an update for the U.S. Preventive Services Task Force. Ann Intern Med. 2004;140:740-53. [PMID: 15126259] LinkGoogle Scholar3. Pedersen JH, Ashraf H, Dirksen A, Bach K, Hansen H, Toennesen P, et al. The Danish randomized lung cancer CT screening trial—overall design and results of the prevalence round. J Thorac Oncol. 2009;4:608-14. [PMID: 19357536] CrossrefMedlineGoogle Scholar4. Saghir Z, Dirksen A, Ashraf H, Bach KS, Brodersen J, Clementsen PF, et al. CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT. Thorax. 2012;67:296-301. [PMID: 22286927] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Portland Veterans Affairs Medical Center, Portland, Oregon; Oregon Health & Science University, Portland, Oregon; and Portland Veterans Affairs Medical Center, Portland, Oregon.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M13-1080. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoScreening for Lung Cancer With Low-Dose Computed Tomography: A Systematic Review to Update the U.S. Preventive Services Task Force Recommendation Linda L. Humphrey , Mark Deffebach , Miranda Pappas , Christina Baumann , Kathryn Artis , Jennifer Priest Mitchell , Bernadette Zakher , Rongwei Fu , and Christopher G. Slatore Screening for Lung Cancer With Low-Dose Computed Tomography John Brodersen , Jakob Fraes Rasmussen , and Bruno Heleno Screening for Lung Cancer With Low-Dose Computed Tomography John Brodersen , Asger Dirksen , and Jesper Holst Pedersen Metrics Cited ByImplementation of a Lung Cancer Screening Program in Two Federally Qualified Health CentersState-Level Variations in the Utilization of Lung Cancer Screening Among Medicare Fee-for-Service BeneficiariesLINC00261 Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage ResponseLung Cancer Screening and Its Impact on Surgical VolumeLung Cancer ScreeningCancer screening in the United States, 2015: A review of current American Cancer Society guidelines and current issues in cancer screeningLung-Cancer Screening with Low-Dose Computed Tomography 4 February 2014Volume 160, Issue 3Page: 212KeywordsCancer screeningComputed axial tomographyConflicts of interestDecision makingDisclosureLung and intrathoracic tumorsLung cancer screeningLungsSystematic reviews ePublished: 4 February 2014 Issue Published: 4 February 2014 CopyrightCopyright © 2014 by American College of Physicians. 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