The Nephrotic Syndrome Due to Pre-eclamptic Nephropathy
Authors: HARRY E. SARLES
Journal: Annals of Internal Medicine (1964)

Case Studies1 August 1964The Nephrotic Syndrome Due to Pre-eclamptic NephropathyReport of a CaseHARRY E. SARLES, M.D., MAURICE E. HERRING, M.D., TREVOR F. WATSON, M.D., RAYMOND L. GREGORY, M.D., PH.D., F.A.C.P., AUGUST R. REMMERS, M.D.HARRY E. SARLES, M.D.Search for more papers by this author, MAURICE E. HERRING, M.D.Search for more papers by this author, TREVOR F. WATSON, M.D.Search for more papers by this author, RAYMOND L. GREGORY, M.D., PH.D., F.A.C.P.Search for more papers by this author, AUGUST R. REMMERS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-2-300 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe development of the nephrotic syndrome during pregnancy is an uncommon occurrence (1, 2). We have recently observed a young primigravida who developed severe pre-eclampsia with massive proteinuria which was followed by the classic features of the nephrotic syndrome. Detailed observations of this patient, including serial renal function studies and renal biopsies during her pregnancy and for 1 year post partum, form the basis of this report. This is the second report of a case of histologically proven pre-eclamptic nephropathy leading to the nephrotic syndrome, the first having been reported by Hopper and associates (3).CASE REPORTA 22-year-old Negro...References1. SIBERMANADAMS IADA: The nephrotic syndrome and pregnancy. New Eng. J. Med. 267: 1286, 1962. CrossrefMedlineGoogle Scholar2. POSNERGOLDMANFORESTER CAJAGV: Pregnancy complicated by nephrotic syndrome: a case report. Amer. J. Obstet. Gynec. 74: 651, 1957. CrossrefMedlineGoogle Scholar3. HOPPERFARQUHARYAMAUCHIMOONPAGE JMGHHDEW: Renal lesions in pregnancy, clinical observations and light and electron microscopic findings. Obstet. Gynec. 17: 271, 1961. Google Scholar4. SCHREINER GE: The nephrotic syndrome, in Diseases of the Kidney, edited by STRAUSS, M. B., WELT, L. G., Little Brown & Co., Boston, 1963, pp. 389-393. Google Scholar5. FREIDELLZENER HVFB: The nephrotic syndrome in pregnancy. Amer. J. Obstet. Gynec. 79: 154, 1960. CrossrefMedlineGoogle Scholar6. SEFTELSCHEWITZ HCLJ: The nephrotic syndrome in pregnancy. J. Obstet. Gynaec. Brit. Comm. 64: 862, 1957. CrossrefGoogle Scholar7. PETERS A: Nephrosis during pregnancy: report of a case. Obstet. Gynec. 17: 202, 1961. Google Scholar8. ALLEN AC: The Kidney—Medical and Surgical Diseases, 2nd ed., Grune & Stratton, New York, 1962, pp. 248, 222-232. Google Scholar9. VASSALLIMORRISMCCLUSKEY PRHRT: The pathogenic role of fibrin deposition in the glomerular lesions of toxemia of pregnancy. J. Exp. Med. 118: 467, 1963. CrossrefMedlineGoogle Scholar10. POLLAKNETTLES VEJB: The kidney in toxemia of pregnancy: a clinical and pathological study based on renal biopsies. Medicine 39: 469, 1960. CrossrefMedlineGoogle Scholar11. PIRANIPOLLAKLANNIGANNETTLESSTEIN CLVERJBP: Light and electronmicroscopic studies on the renal lesions in toxemia of pregnancy with observations on some clinicopathologic relationships. Path. Microbiol. (Basel) 24: 586, 1961. MedlineGoogle Scholar12. BURCHPEARLSTERNBERG RRMAWH: A clinicopathologic study of the nephrotic syndrome. Ann. Intern. Med. 56: 54, 1962. LinkGoogle Scholar13. KARKPIRANIPOLLAKMEUHRCKEBLAINEY RMCLVERCJD: The nephrotic syndrome in adults: a common disorder with many causes. Ann. Intern. Med. 49: 751, 1958. LinkGoogle Scholar14. METCOFF J: The nephrotic syndrome, in Renal Disease, edited by BLACK, D. A. K., F. A. Davis Company, Philadelphia, 1962, pp. 239-243. Google Scholar15. KUMARFELTHAMGORNALL DLAAG: Aldosterone excretion and tissue electrolytes in normal pregnancy and pre-eclampsia. Lancet 1: 541, 1959. CrossrefMedlineGoogle Scholar16. DENNISSMYTHEMCIVERHOWE EJCMFAHG: Percutaneous renal biopsy in eclampsia. Amer. J. Obstet. Gynec. 87: 364, 1963. CrossrefMedlineGoogle Scholar17. BUCHTWERKO HL: Glomerular filtration rate and renal blood flow in hypertensive toxemia of pregnancy. J. Obstet. Gynaec. Brit. Comm. 60: 157, 1953. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Galveston, TexasFrom the Departments of Internal Medicine and Obstetrics and Gynecology of the University of Texas Medical Center, Galveston, Texas.This work was supported by funds from the United States Public Health Service under grant SO1FR0512701. Some of these studies were performed during hospitalization in the Clinical Study Center, University of Texas Medical Center, Galveston, Texas, under support of grant FR-73, National Institutes of Health, United States Public Health Service, Bethesda, Maryland.Requests for reprints should be addressed to Harry E. Sarles, M.D., Department of Internal Medicine, University of Texas Medical Center, Galveston, Texas 77551. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPre-eclampsia with the nephrotic syndromeNephrotic proteinuria with pre-eclampsiaMalignant nephrosclerosis during pregnancy and in the postpartum period (the uremic hemolytic syndrome)Nephrotic syndrome in pregnancyPregnancy following the surgical treatment of portal hypertensionPathoanatomie der Nierenveränderungen in der SchwangerschaftChronic renal diseases and pregnancy: A review 1 August 1964Volume 61, Issue 2Page: 300-307KeywordsBiopsyHospitalizationsMedical servicesObstetrics and gynecologyPregnancyPrevention, policy, and public healthProteinuria Issue Published: 1 August 1964 PDF DownloadLoading ...