tbuckley/cabot-search huggingface dataset:
Alcohol degradation and bromsulphthalein metabolism in acute alcoholic liver disease.
Authors: P Wilkinson, D M O'Day, J G Rankin
Journal: Gut (1969)

A very early consequence of excessive alcohol ingestion is a reduction in the capacity of the human liver to store injected bromsulphthalein (BSP) at concentrations above those in the plasma (Wilkinson, O'Day, Breen, and Rankin, 1968).This biochemical defect, which is unrelated to morphological changes in the liver, occurs without alteration in biliary excretion of the dye, and is reversiblewith abstinence.The defect appears to be a direct toxic effect of ethanol for it is related to the time since alcohol was last drunk, but not to the type of alcoholic beverage nor to the patient's nutritional state.The mechanism by which ethanol produces this biochemical abnormality is not clear.Possible explanations include changes in hepatic blood flow, alterations at the cell boundary, or damage to intra- cellular enzymes.Ethanol has been shown to produce ultrastructural changes in the livers of alcoholic (Rubin and Lieber, 1967) and non-alcoholic volun- teers (Rubin and Lieber, 1968) independent of nutritional factors.Among the cytoplasmic organ- elles consistently altered was the smooth endoplasmic reticulum, which is known to be a primary site for drug metabolism (Conney, 1967).Damage to this structure could thus lead to altered BSP metabolism.Ethanol too is metabolized by the liver cell, though by pathways which are probably quite distinct from those of BSP elimination.Any interrelation or interdependence between the metabolism of the two substances would suggest some common mechanism.This paper reports a study in which ethanol degradation and BSP metabolism were measured simultaneously in a group of patients with acute alcoholic liver disease.It was hoped that such a study might provide further information, not only about thenature ofthe storage defect caused by excessive drinking, but also about pathways of normal BSP metabolism.Patients with established cirrhosis were excluded since permanent changes in both BSP metabolism (Wheeler, Meltzer, and Bradley, 1960;
Curative endoscopic therapy in patients with early esophageal squamous-cell carcinoma or high-grade intraepithelial neoplasia
Authors: O. Pech, A. May, L. Gossner, T. Rabenstein, H. Manner, J. Huijsmans, M. Vieth, M. Stolte, M. Berres, C. Ell
Journal: Endoscopy (2007)

See also: Commentaire de travail de O. Pech et al., pp. 30Endoscopy 2007; 39(01): 191-191DOI: 10.1055/s-0032-1306908
TCT-746 Physicians' Response To Platelet Function Testing After Percutaneous Coronary Therapy: Does High On-Treatment Platelet Reactivity Testing Impact Antiplatelet Strategy?
Authors: Gabriel Sardi, Joshua Loh, Hironori Kitabata, Rebecca Torguson, Kenneth Kent, Lowell Satler, William Suddath, Augusto Pichard, Ron Waksman
Journal: Journal of the American College of Cardiology (2012)
THE IDENTIFICATION OF DEXTROSE IN HUMAN URINE.
Authors: HEINRICH STERN
Journal: JAMA (1900)

Dextrose, in insignificant traces a constituent of almost every normal urine, can be readily demonstrated in the renal excretion, provided it occurs in sufficient amounts. The moment, however, that urinary grape-sugar is detected by the more commonly employed methods, it indicates a deviation from the normal systemic state. Thus, in glycosuria, no specific pathologic element makes its appearance, but a regular constituent of excessively increased quantity. While, as a rule, glucose can be positively identified in urines containing 0.5 per cent. or more of it, great difficulty in this respect is often experienced when smaller amounts are present. Glycosuria, a well-defined condition, resulting from or concurring with some systemic anomaly, is most always recognized by the painstaking physician; yet, certain systemic occurrences—physiologic or pathologic—may be erroneously diagnosed as glycosuria, when, as a matter of fact, grape-sugar in appreciable quantities was never discharged by the urine. Coinciding with pseudoglycosuria, there may
The Treatment of Hyperthyroidism
Authors: Earle M. Chapman
Journal: New England Journal of Medicine (1961)

Treatment with Radioactive IodineRadioactive iodine has created a revolution in the treatment of hyperthyroidism. Whereas surgical treatment gained pre-eminence through the early decades of the century, especially after the beneficial effects of iodine were re-established, it was about mid-century that ablation of the thyroid gland by means of orally administered ionizing radiation gained recognition as a neat and less troublesome therapy. The past decade has seen a rapid rise in its use so that, by 1961, it is estimated that almost 100,000 persons have been treated with radioactive iodine (I131). After twenty years of use, the fear of . . .
Method of Yellow Fever Transmission.
Authors: QUITMAN KOHNKE
Journal: JAMA (1903)

New Orleans, Jan. 7, 1903. <h3>To the Editor:</h3> —InThe Journal(Jan. 3, 1903, page 50) is a report of the discussion, at the recent session of the American Public Health Association, of the method of transmission of yellow fever.The Journalcan not, of course, publish a full report of such a discussion, and the report published, therefore, must necessarily be incomplete and imperfect. Your reporter has placed me in a position which I do not desire to occupy. I am sure the error would ordinarily be considered a matter of small importance not worthy of correction, but my convictions on the subject of quarantine against yellow fever are so strong, and my interest in the subject so intense that I beg the privilege of correcting your report in so far as it refers to myself. What I said was that "Quarantine should be<i>most</i>strenuous against that which
STUDIES ON THE LOCALIZATION OF CIRCULATING ANTIGEN-ANTIBODY COMPLEXES AND OTHER MACROMOLECULES IN VESSELS
Authors: Charles G. Cochrane
Journal: The Journal of Experimental Medicine (1963)

A short term model in which circulating antigen-antibody complexes and host complement localized in vessel walls of guinea pigs was analyzed. Localization was accomplished by subjecting the animals to anaphylactic shock. The circulating macromolecules, such as antigen-antibody complexes, appeared to localize by being trapped in the vessel wall along the basement membrane that acted as a filter during a state of increased permeability of the vessel. It was suggested that this point of localization between the endothelial cell and the basement membrane may well represent the earliest focus of inflammation in diseases caused by the deposition of injurious macromolecules such as soluble antigen-antibody complexes from the blood stream. Complexes localized in the vessel walls did not provoke Arthus-type vasculonecrotic reactions even though in both these vessels and in cutaneous Arthus reactions antibody, antigen, and host complement (C'3c) were deposited in the vessel walls. The possibility was presented that since circulating macromolecules and probably complexes deposited in (a) relatively small amounts, and (b) in a position beneath endothelial cells, they were not strongly chemotactic toward circulating polymorphonuclear leukocytes. Vasculonecrotic reactions, therefore, were not observed. It was brought out that this may be similar to the situation in glomerulonephritis induced by localized immune complexes, in which severe necrosis is not observed. In the Arthus vascular reaction, host complement was found microscopically accumulated with the immune reactants in affected vessel walls.
Coagulopathy Associated With Moxalactam
Authors: Stephen Lee, Susanne Spira, E. Peter Gabor
Journal: JAMA (1983)

<h3>To the Editor.—</h3> We read the article by R. L. Pakter et al (1982;248:1100) about the coagulopathy associated with the use of moxalactam disodium. We have seen three cases recently of qualitative platelet defects associated with the use of moxalactam that we would like to report. <h3>Report of Cases.—Case 1.—</h3> An 86-year-old man was admitted to the hospital with cerebrovascular accident. He needed gastrostomy tube insertion. Results of Quick's prothrombin time, partial thromboplastin time (PTT), and bleeding time tests were normal preoperatively. Aspiration pneumonias developed and therapy with moxalactam was started. Subsequent to this, the PTT prolonged to 64 s (normal, &lt;40 s), and the Simplate bleeding time was more than 30 minutes (normal, less than seven minutes). Platelet aggregometry showed no reaction with collagen and disaggregation with high-dose adenosine diphosphate. Ristocetin and epinephrine levels were normal. Moxalactam administration was discontinued, and the patient was treated with vitamin
Endothelium-Dependent Coronary Vasomotion Relates to the Susceptibility of LDL to Oxidation in Humans
Authors: Todd J. Anderson, Ian T. Meredith, François Charbonneau, Alan C. Yeung, Balz Frei, Andrew P. Selwyn, Peter Ganz
Journal: Circulation (1996)

Background Oxidatively modified LDL has been shown to markedly impair endothelium-dependent dilation in experimental studies. The aim of the present study was to determine the relation between the coronary vasomotor response to the endothelium-dependent agonist acetylcholine and the in vitro susceptibility of LDL to oxidation in patients. Methods and Results Endothelium-dependent coronary vasomotion in response to acetylcholine (10 −8 to 10 −6 mol/L) was assessed in 23 patients with hypercholesterolemia (mean age, 56±9 years) after 1 year of therapy with either an American Heart Association Step 1 diet (seven patients), lovastatin and cholestyramine (seven patients), or lovastatin and probucol (nine patients). The susceptibility of LDL to oxidation was determined by measuring the lag phase of conjugated diene formation induced by Cu 2+ . Patients treated with lovastatin and probucol had prolongation of the lag phase (263±64 minutes) compared with diet- (91±22 minutes) or lovastatin and cholestyramine– (118±57 minutes) treated patients ( P &lt;.0001). By univariate analysis, the coronary vasomotor response to acetylcholine was significantly related to the lag phase of conjugated diene formation ( P =.002), cholesterol-lowering therapy ( P =.002), and serum cholesterol ( P =.02). By multivariate analysis, the lag phase remained a significant predictor of the acetylcholine vasomotor response, independent of the effect of cholesterol-lowering treatment. Conclusions In patients treated with lipid-lowering agents, the vasodilator response to acetylcholine is related to the susceptibility of LDL to oxidation. These findings suggest that oxidative stress is an important determinant of the coronary endothelial dysfunction observed in patients with atherosclerosis and hypercholesterolemia.
Abstract 1567: The multi-targeted kinase inhibitor Sunitinib blocks VEGF-C signaling pathway and lymphangiogenesis
Authors: Kodera Yasuo, Yasufumi Katanasaka, Yuuka Kitamura, Tomohide Tamura, Fumiaki Koizumi
Journal: Cancer Research (2010)

Abstract Metastasis is the main cause of therapeutic failure and death in cancer patient. Tumor cells disseminate to distant organs through lymphatic and blood vessels. The degree of metastasis in regional lymph nodes is a prognostic factor and determines treatment course of patients. Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) family regulate angiogenesis and lymphangiogenesis. Several clinical studies have shown that the expression of VEGF-C is associated with lymphangiogenesis and lymph node metastasis in many different types of cancer. Sunitinib is a tyrosine kinase inhibitor that inhibits VEGFR, PDGFR, KIT, FLT3, RET, and CSF1R. The main mechanism for tumor growth inhibition is thought to be anti-angiogenic effect by inhibiting VEGFR-2 kinase activity. However, the effect of sunitinib on VEGF-C/VEGFR-3 pathway and lymphangiogenesis remain unclear. Therefore, we evaluated the effect of sunitinib on lymphangiogenesis with using lymphatic endothelial cell (LEC) and imaging breast cancer model. Sunitinib inhibited VEGF-C-induced phosphorylation of VEGFR-3, Akt and ERK1/2 at submicromolar level in LEC. Additionally, the growth and tube formation were also blocked by sunitinib. Furthermore, sunitinib treatment significantly suppressed tumor lymphangiogenesis and axillary lymph node metastasis as evaluated by photon counting method. These results suggest that Sunitinib may be beneficial for breast cancer patients by inhibiting lymph node metastasis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1567.
LEFT ATRIAL SPHERICITY: A NEW METHOD TO ASSESS LEFT ATRIAL REMODELING. IMPACT ON THE OUTCOME OF PULMONARY VEIN ISOLATION
Authors: Felipe Bisbal, Esther Guiu, Naiara Calvo, Roger Borràs, Elena Arbelo, Bárbara Vidal, David Marin, Jose M. Tolosana, Antonio Berruezo, Teresa M. Caralt, Marta Sitges, Josep Brugada, Lluís Mont
Journal: Journal of the American College of Cardiology (2013)
Sub-Saharan Africa's Mothers, Newborns, and Children: How Many Lives Could Be Saved with Targeted Health Interventions?
Authors: Ingrid K. Friberg, Mary V. Kinney, Joy E. Lawn, Kate J. Kerber, M. Oladoyin Odubanjo, Anne-Marie Bergh, Neff Walker, Eva Weissman, Mickey Chopra, Robert E. Black
Journal: PLoS Medicine (2010)

As part of the series on maternal, neonatal, and child health in sub-Saharan Africa, Robert Black and colleagues estimated mortality reduction for 42 countries and conclude that the use of local data is needed to prioritize the most effective mix of interventions.
Doctors in Israel oppose open performance data
Authors: J. Siegel-Itzkovich
Journal: BMJ (1999)

The enactment of Israel's new Freedom of Information Law at the end of May has put the health authorities and the Israel Medical Association in a quandary. Should surveys on hospitals' and doctors' performance and patient satisfaction be published listing names of institutions and individuals?

The new law requires government ministries to supply all information to the public that need …
Structure of the NMDA Receptor Channel M2 Segment Inferred from the Accessibility of Substituted Cysteines
Authors: Thomas Kuner, Lonnie P. Wollmuth, Arthur Karlin, Peter H. Seeburg, Bert Sakmann
Journal: Neuron (1996)

The structure of the NMDA receptor channel M2 segment was investigated by probing the extracellular and cytoplasmic faces of cysteine-substituted NR1-NR2C channels with charged sulfhydryl-specific reagents. The pattern of accessible positions suggests that the M2 segment forms a channel-lining loop originating and ending on the cytoplasmic side of the channel, with the ascending limb in an alpha-helical structure and the descending limb in an extended structure. A functionally critical asparagine (N-site) is positioned at the tip of the loop, and a cluster of hydrophilic residues of the descending limb, adjacent to the tip, forms the narrow constriction of the channel. An apparent asymmetric positioning of the NR1- and NR2-subunit N-site asparagines may account for their unequal role in Ca2+ permeability and Mg2+ block.
Pregnancy and successful labor in the course of chronic lymphocytic leukemia
Authors: Günhan Gürman
Journal: American Journal of Hematology (2002)

Pregnancy and leukemia are difficult to manage. Protecting the mother from hemorrhage and infection and the fetus from developmental failure are the main aims. Chronic lymphocytic leukemia (CLL) has been seen very rarely with pregnancy. In this article, the successful labor of a 43-year-old woman with CLL is reported. She was not a candidate for chemotherapy at that time. She was without symptoms when she got pregnant. In the 30th gestational week she was found to have urinary tract infection and preterm labor and she was stabilized. Gestational diabetes and preeclampsia were also determined after that period and managed. The patient was delivered by cesarean section in the 39th gestational week. Cord blood was collected and preserved. No postpartum complication was seen in either the patient or the infant. This is one of the rare cases presenting CLL with pregnancy in the literature.
Return to The House of God: Medical Resident Education 1978–2008
Authors: Matthew J. Dolan
Journal: Annals of Internal Medicine (2009)

Medical Writings: Book Notes4 August 2009Return to The House of God: Medical Resident Education 1978–2008Matthew J. Dolan, MDMatthew J. Dolan, MDFrom the Henry M. Jackson Foundation, Lackland Air Force Base, Texas.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-3-200907070-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Kohn M, Donley C, eds. 256 pages. Kent, OH: Kent State Univ Pr; 2008. $24.95. ISBN 9780873389839. Order at upress.kent.edu/books/.Format: Softcover book.Field of medicine: Internal medicine residency training.Audience: Residents, teaching faculty, and other physicians with interest in medicine residency training.Purpose: To bring together a volume of critical and reflective essays marking the 30th anniversary of The House of God: The Classic Novel of Life and Death in an American Hospital.Content: The book is a collection of thoughtful and well-written essays grouped by such themes as historical perspective and the laws of The House of God, ... Author, Article, and Disclosure InformationAffiliations: From the Henry M. Jackson Foundation, Lackland Air Force Base, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 4 August 2009Volume 151, Issue 3Page: 220KeywordsMedical educationPerceptionResidency ePublished: 4 August 2009 Issue Published: 4 August 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Fundamentals of Obstetrics and Gynaecology, Vol 1, Obstetrics
Authors: Robert E. L. Nesbitt
Journal: JAMA (1970)

This is a well-written textbook which is addressed primarily to the undergraduate student and junior resident who need a fairly inclusive view of the essentials of obstetrics. It does encompass a rather comprehensive review of operative techniques but for the most part the fundamentals are emphasized. Only 35 references are noted but by and large these are carefully chosen British and American volumes which are well-known treatises containing full bibliographies. There are over 200 line drawings as well as appropriate photographs, including impressive reproductions of radiographs. Although the print is of somewhat reduced dimension, it is easily readable, the book binding is of good quality, and all illustrative depictions are clear. This reviewer is particularly impressed by the crisp, lively style of writing which has been stripped of all extraneous rhetoric and ambiguities. For the most part, abstruse controversial matters have been deleted. Only an author of vast personal experience
OUTCOMES AND SURVIVAL WITH AORTIC VALVE REPLACEMENT COMPARED WITH MEDICAL THERAPY IN PATIENTS WITH LOW-, MODERATE- AND SEVERE-GRADIENT SEVERE AORTIC STENOSIS AND NORMAL LEFT VENTRICULAR EJECTION FRACTION
Authors: Wilbert S. Aronow, Omar Khalique, Robert N. Belkin, Chul Ahn, Mala Sharma
Journal: Journal of the American College of Cardiology (2011)
Serum‐free light chain analysis by crossed immunoelectrophoresis: Correlation with plasmapheresis in light chain disease nephropathy
Authors: Bruce C. McLeod, Ann L. Viernes, Richard J. Sassetti
Journal: American Journal of Hematology (1983)

Abstract The technique of crossed immunoelectrophoreis (X‐IEP) has been used to quantify free monoclonal light chains (LC) directly in the serum of patients with light chain disease, without preliminary gel or membrane filtration of serum to separate whole immunoglobulin. LC concentration is proportional to the area under an immunoprecipitin peak formed by LC in the patient's serum and an anti‐LC antibody of appropriate specificity. Light chains of beta electrophoretic mobility can be processed in the standard X‐IEP technique at pH 8.6. Light chains of gamma mobility must be processed in a modified technique using a pH of 5.0 and a carbamylated antiserum in the second dimension gel. Dose response curves obtained from the method in serial dilution experiments with sera from 18 patients gave correlation coefficients ± 0.99. Replicate measurements of absolute LC concentration on the same specimens were within ± 10%. The method can also detect polymerized light chains. Serum light chain levels were measured during the course of plasmapheresis therapy in three patients with light chain disease and renal failure. Light chain levels were shown to fall after plasmapheresis and to rise rather rapidly in the interval between treatments.
Effect of cimetidine on the human lower oesophageal sphincter.
Authors: D H Osborne, J Lennon, M Henderson, G Lidgard, R Creel, D C Carter
Journal: Gut (1977)

Lower oesophageal sphincter pressures in healthy volunteers were measured by a rapid pull-through technique during intravenous infusion of the histamine H2-receptor antagonist, cimetidine. No consistent effects on sphincter pressure were observed which are liable to be of clinical importance. Serum gastrin concentrations during cimetidine infusion were measured by radioimmunoassay and showed no significant variation. In a further series of experiments, the response of the lower oesophageal sphincter to intravenous bolus injection of pentagastrin was measured before and during cimetidine infusion. Cimetidine infusion had no significant effect on the sphincter response to pentagastrin.
The Right of Privacy Protects the Doctor-Patient Relationship
Authors: Glenn H. Lytle
Journal: JAMA (1990)

<h3>To the Editor.—</h3> In a recent article<sup>1</sup>about the doctor-patient relationship, two assumptions were made. I believe these assumptions were misleading. These assumptions were then used to equate the principle of the doctor-patient relationship with the right to have an abortion. In the authors' initial section of their essay, they state that "it is thus no longer possible to believe realistically that the issues raised by abortion laws involve abortion alone: they raise the fundamental questions of how far the state can go to control physicians." I am one who is actively seeking to overturn the legality of abortion on demand. The issue is abortion, an immoral and disgusting act. The outrage is against this act, and in no way does restricting abortions interfere with the principle of the doctor-patient relationship. This relationship is already justifiably limited by the laws of the land. For example, the fact that we
Case Report: Adrenal Oncocytoma Associated with Markedly Increased FDG Uptake and Immunohistochemically Positive for GLUT1
Authors: Naomi Sato, Yasuhiro Nakamura, Kentaro Takanami, Yoshikiyo Ono, Kei Omata, Ryo Morimoto, Fumitoshi Satoh, Kazue Ise, Shigeyuki Yamada, Atsuko Kasajima, Fumiyoshi Fujishima, Mika Watanabe, Yoichi Arai, Hironobu Sasano
Journal: Endocrine Pathology (2014)