Protracted Cholestatic Hepatitis after the Use of Prostata
Authors: Saeed Hamid
Journal: Annals of Internal Medicine (1997)

Letters15 July 1997Protracted Cholestatic Hepatitis after the Use of ProstataSaeed Hamid, MD, Sergio Rojter, MD, and John Vierling, MDSaeed Hamid, MDSouthwestern Medical Center; Dallas, TX 75235-9151, Sergio Rojter, MDSouthwestern Medical Center; Dallas, TX 75235-9151, and John Vierling, MDSouthwestern Medical Center; Dallas, TX 75235-9151Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-2-199707150-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:One reason for the growing popularity of herbal medicines is the perception that these compounds are safe and free of side effects. We report a case of acute hepatitis caused by Prostata (Gero Vita International), an herbal preparation used to treat prostatic hypertrophy.A 65-year-old man with nocturia and hesitancy began taking Prostata, which had been ordered from a catalogue. Two weeks later, he developed jaundice and severe pruritus and stopped taking the medication. His abdomen was not tender, and his liver and spleen were not palpable. Biochemical findings were as follows: bilirubin level, 8.2 mg/dL; aspartate ...References1. Champault M, Patel JC, Bonnard AM. A double-blind trial of an extract of the plant Serenoa repens in benign prostatic hyperplasia. Br J Clin Pharmacol. 1984; 18:461-2. Google Scholar2. Kottra LL, Kappas A. Effect of estradiol on plasma disappearance rate of sulfobromophthalein in man. Arch Intern Med. 1966; 117:373-5. Google Scholar3. Haemmerli HU. Jaundice during pregnancy. In: Schiff L, ed. Diseases of the Liver. 4th ed. Philadelphia: JB Lippincott; 1975:1336-48. Google Scholar4. Dankoff JS. Near fatal liver dysfunction secondary to administration of flutamide for prostate cancer. J Urol. 1992; 148:1914. Google Scholar5. Marchetti B, Labrie F. Characteristics of flutamide action on prostate and testicular functions in the rat. J Steroid Biochem. 1988; 29:691-8. Google Scholar Author, Article, and Disclosure InformationAuthors: Saeed Hamid, MD; Sergio Rojter, MD; John Vierling, MDAffiliations: Southwestern Medical Center; Dallas, TX 75235-9151 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySaw Palmetto (Serenoa repens Sabal serrulatum)Herbs and their bioactive ingredients in cardio-protection: Underlying molecular mechanisms and evidences from clinical studiesSuspected adverse reactions to performance enhancing dietary supplements: Spontaneous reports from the Italian phytovigilance systemAdverse Effects of Nutraceuticals and Dietary SupplementsDrugs and ToxinsLiver toxicity related to herbs and dietary supplements: Online table of case reports. 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