tbuckley/cabot-search huggingface dataset:
PWE-223 Gastroenterology investigations for iron deficiency anaemia (IDA) in patients with acute coronary syndrome awaiting cardiac interventions. How good are our cardiology colleagues?
Authors: Z U Rahman, M Mansoor, T Hamid, O Latif, S Campbell
Journal: Gut (2012)

<h3>Introduction</h3> Anaemia is associated with increased risk of morbidity and mortality in patients with ischaemic heart disease (IHD) and heart failure. Incidental anaemia in patients awaiting coronary interventions is common particularly in our elderly populations. Currently there are no clear guidelines how to investigate these patients. The elderly patients have a higher RR of having occult GI malignancy and endoscopy is the gold standard to identify early disease. Majority of the physicians refer patients with anaemia to gastroenterologists routinely to exclude GI pathology. Endoscopic investigations are however not without complications and generally contraindicated during acute coronary syndrome. <h3>Methods</h3> This is a retrospective analysis of patients with anaemia admitted with acute coronary syndrome to our hospital. Information was collected from patient records and endoscopy reporting database over a period of 2 years (January 2009–December 2010). We analysed all the investigations, outcomes/diagnosis of these patients. The data were analysed by Standard statistical methods. <h3>Results</h3> A total of 230 patients were identified by the coding department with anaemia and IHD who were admitted over a period of 24 months. However, only 61 (26.5%) patients were investigated for anaemia. The mean age was 70±19 years with 77% (47/61) were more than 60 years of age. Serum Ferritin was checked in only 50% (31/61) of these patients before referral, out of which 71% (22/31) patients had low levels. Coeliac serology was done in only 5% (3/61) patients, which was normal. 75.5% (46/61) of the referred patients underwent Oesophagogastroduodenoscopy (OGD), 13.04% (6/46) had non-erosive gastritis and 8.69% had peptic ulcer. Others had angiodysplasia, gastric erosions, gastric polyps and hiatus hernia in 4.3% each. OGD was normal in the rest; none had cancer or active bleeding. Colonoscopy was performed in 54.09% (33/61) patients and CT colonogram in 5%. Colorectal cancer was found 8.33% (3/36) patients, benign polyps in 5.55% and diverticulosis in 22%. <h3>Conclusion</h3> A large number (73%; 169/230) of the anaemic patients with IHD were not referred to rule out gastrointestinal cause of anaemia. Coeliac serology is poorly checked by the Cardiologists. The prevalence of colorectal cancer was high that is, 8.33% in the small proportion of those referred. We suggest appropriate screening and thorough evaluation of anaemia in cardiology setting. This can be done by following British Society of Gastroenterology guidelines for investigation of iron deficiency anaemia. Education of colleagues would be of paramount importance in optimising appropriate referral practice. <h3>Competing interests</h3> None declared.
Humanitarian action: the duty of all doctors
Authors: V. Nathanson
Journal: BMJ (1997)

Humanitarian is defined by Webster's dictionary as “having concern for or helping to improve the welfare and happiness of mankind.” In that sense all doctoring is humanitarian. A second definition goes further: “a person actively engaged in promoting human welfare and social reforms.” Many doctors are not active in promoting social reform, but should they be? Every doctor knows that those who live on the margins of our world—those who are poor, vulnerable, elderly, addicted, insane, imprisoned, unemployed, discriminated against, tortured, homeless, condemned, caught up in wars—have higher rates of sicknessand ill health. Doctors should be paying great attention to those people, but too often, like everyone else, they neglect them. The poor have greater difficulty than the rich in accessing health care; prisoners get a second class service; doctors propose that the addicted—smokers, drug misusers—should be denied treatments like coronary bypass grafting. This issue of the BMJ has gathered together articles that deal with humanitarian issues, and although many concern people in poor, war torn countries, not all do.

The main reason for publishing this special issue now is that next week in Ottawa the world's nations will try again to take effective action against antipersonnel landmines. A hundred years ago the BMJ published papers on the injuries caused by particular types of …
INVOLVEMENT OF THE CORNEA AND BULBAR CONJUNCTIVA IN THE SECONDARY STAGE OF SYPHILIS.
Authors: BROWN PUSEY
Journal: JAMA (1907)

Involvement of the cornea in the secondary stage of syphilis is not referred to in the literature as a possibility. Its neighboring structure, the conjunctiva bulbi, in a few instances, has been found involved in the secondary manifestations of this disease, but such involvement is of the greatest rarity, a careful search of the literature revealing records of only a few such cases. Recently, in my service at the Cook County Hospital, I had a case showing secondary syphilitic pustular eruptions involving the cornea and the conjunctiva of the globe and lids. <h3>Patient.</h3> —T. O., aged 22, male, a porter by occupation, was admitted to the dermatologic division of Cook County Hospital April 19, 1905, where the diagnosis of syphilis in the secondary stage, which was made at the receiving room, was confirmed by the attending dermatologist, Dr. William Allen Pusey. On the following day, because of the eye conditions,
Reversible renal damage due to glue sniffing.
Authors: A M Will, E H McLaren
Journal: BMJ (1981)

Exacerbation of diazepam-induced phlebitis by oral penicillamine Penicillamine, a heavy metal antagonist, is used in the treatment of Wilson's disease, cystinuria, rheumatoid arthritis, and various other conditions.Adverse reactions to the drug are many and frequent and range in severity from gastrointestinal distress, stomatitis, unpleasant skin odours, and rashes to proteinuria, leucopenia, and thrombocytopenia.1 Up to one-third of patients given the drug for rheuma- toid arthritis have to discontinue treatment because of toxicity.'Intravenous diazepam is widely used as a sedative, muscle relaxant, and anticonvulsant.Local complications with this drug, including pain at injection site, phlebitis, and thrombophlebitis, have likewise been reported frequently.2We describe a patient who developed phlebitis from intravenous diazepam.The phlebitis resolved with local heat but recurred on two separate occasions after oral penicillamine.
M3 Muscarinic Receptor Antagonists Inhibit Small Cell Lung Carcinoma Growth and Mitogen-Activated Protein Kinase Phosphorylation Induced by Acetylcholine Secretion
Authors: Pingfang Song, Harmanjatinder S. Sekhon, Allison Lu, Juan Arredondo, David Sauer, Courtney Gravett, Gregory P. Mark, Sergei A. Grando, Eliot R. Spindel
Journal: Cancer Research (2007)

Abstract The importance of acetylcholine as a neurotransmitter in the nervous system is well established, but little is yet known about its recently described role as an autocrine and paracrine hormone in a wide variety of nonneuronal cells. Consistent with the expression of acetylcholine in normal lung, small cell lung carcinoma (SCLC) synthesize and secrete acetylcholine, which acts as an autocrine growth factor through both nicotinic and muscarinic cholinergic mechanisms. The purpose of this study was to determine if interruption of autocrine muscarinic cholinergic signaling has potential to inhibit SCLC growth. Muscarinic receptor (mAChR) agonists caused concentration-dependent increases in intracellular calcium and mitogen-activated protein kinase (MAPK) and Akt phosphorylation in SCLC cell lines. The inhibitory potency of mAChR subtype–selective antagonists and small interfering RNAs (siRNAs) on acetylcholine-increased intracellular calcium and MAPK and Akt phosphorylation was consistent with mediation by M3 mAChR (M3R). Consistent with autocrine acetylcholine secretion stimulating MAPK and Akt phosphorylation, M3R antagonists and M3R siRNAs alone also caused a decrease in basal levels of MAPK and Akt phosphorylation in SCLC cell lines. Treatment of SCLC cells with M3R antagonists inhibited cell growth both in vitro and in vivo and also decreased MAPK phosphorylation in tumors in nude mice in vivo. Immunohistochemical staining of SCLC and additional cancer types showed frequent coexpression of acetylcholine and M3R. These findings suggest that M3R antagonists may be useful adjuvants for treatment of SCLC and, potentially, other cancers. [Cancer Res 2007;67(8):3936–44]
Phase II Study of Cediranib in Patients with Malignant Pleural Mesothelioma: SWOG S0509
Authors: Linda L. Garland, Kari Chansky, Antoinette J. Wozniak, Anne S. Tsao, Shirish M. Gadgeel, Claire F. Verschraegen, Marco A. DaSilva, Mary Redman, David R. Gandara
Journal: Journal of Thoracic Oncology (2011)
Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis
Authors: Tilman Ziegler, Jan Horstkotte, Claudia Schwab, Vanessa Pfetsch, Karolina Weinmann, Steffen Dietzel, Ina Rohwedder, Rabea Hinkel, Lisa Gross, Seungmin Lee, Junhao Hu, Oliver Soehnlein, Wolfgang M. Franz, Markus Sperandio, Ulrich Pohl, Markus Thomas, Christian Weber, Hellmut G. Augustin, Reinhard Fässler, Urban Deutsch, Christian Kupatt
Journal: Journal of Clinical Investigation (2013)

Septic shock is characterized by increased vascular permeability and hypotension despite increased cardiac output. Numerous vasoactive cytokines are upregulated during sepsis, including angiopoietin 2 (ANG2), which increases vascular permeability. Here we report that mice engineered to inducibly overexpress ANG2 in the endothelium developed sepsis-like hemodynamic alterations, including systemic hypotension, increased cardiac output, and dilatory cardiomyopathy. Conversely, mice with cardiomyocyte-restricted ANG2 overexpression failed to develop hemodynamic alterations. Interestingly, the hemodynamic alterations associated with endothelial-specific overexpression of ANG2 and the loss of capillary-associated pericytes were reversed by intravenous injections of adeno-associated viruses (AAVs) transducing cDNA for angiopoietin 1, a TIE2 ligand that antagonizes ANG2, or AAVs encoding PDGFB, a chemoattractant for pericytes. To confirm the role of ANG2 in sepsis, we i.p. injected LPS into C57BL/6J mice, which rapidly developed hypotension, acute pericyte loss, and increased vascular permeability. Importantly, ANG2 antibody treatment attenuated LPS-induced hemodynamic alterations and reduced the mortality rate at 36 hours from 95% to 61%. These data indicate that ANG2-mediated microvascular disintegration contributes to septic shock and that inhibition of the ANG2/TIE2 interaction during sepsis is a potential therapeutic target.
Psychotherapy in the Twenty-first Century An Exploration of the Basic Determinants and Trends of Psychotherapy in our Future Society
Authors: St. Lesse, W. Wolf
Journal: Psychotherapy and Psychosomatics (1968)

Research Articles| February 12 2010 Psychotherapy in the Twenty-first Century. An Exploration of the Basic Determinants and Trends of Psychotherapy in our Future Society Subject Area: Psychiatry and Psychology St. Lesse; St. Lesse New York Search for other works by this author on: This Site PubMed Google Scholar W. Wolf W. Wolf New York Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1968) 16 (1-3): 47–54. https://doi.org/10.1159/000285916 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation St. Lesse, W. Wolf; Psychotherapy in the Twenty-first Century. An Exploration of the Basic Determinants and Trends of Psychotherapy in our Future Society. Psychother Psychosom 31 December 1968; 16 (1-3): 47–54. https://doi.org/10.1159/000285916 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1968Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Gamma-interferon in evolving allergic contact dermatitis reactions
Authors: C.A. Morton, I. Campbell, R.M. MacKie
Journal: British Journal of Dermatology (1996)

Journal Article Gamma‐interferon in evolving allergic contact dermatitis reactions Get access C.A. Morton, C.A. Morton Department of Dermatology, University of Glasgow, Glasgow G12 8QQ Search for other works by this author on: Oxford Academic Google Scholar I. Campbell, I. Campbell Department of Dermatology, University of Glasgow, Glasgow G12 8QQ Search for other works by this author on: Oxford Academic Google Scholar R.M. MacKie R.M. MacKie Department of Dermatology, University of Glasgow, Glasgow G12 8QQ Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 135, Issue 5, 1 November 1996, Pages 853–855, https://doi.org/10.1111/j.1365-2133.1996.tb03903.x Published: 01 November 1996
Trichophyton rubrum infections according to age, anatomical distribution and sex
Authors: F. BLANK, S.J. MANN
Journal: British Journal of Dermatology (1975)

Trichophyton rubrum caused 72.9% of the cases of dermatophytosis observed in a sample of caucasoids from Philadelphia. Tinea pedis was found in 84% of the female and male patients with dermatophytosis. Tinea manuum occurred with equal frequency in both sexes whereas tinea unguium was more prevalent in females. Tinea cruris occurred almost exclusively in males. Infections of two or more anatomical sites were observed more frequently in males. The data are compared with those reported by Rosman (1966) from a similar study done in Copenhagen.
Abstract 4976: Telomerase-specific replication-selective virotherapy combined with radiation therapy for oral squamous cell carcinoma cells
Authors: Yuji Kurihara, Daisuke Sato, Tatsuo Shirota, Seiji Kondo, Masafumi Kataoka, Yasuo Urata, Toshiyoshi Fujiwara, Satoru Shintani
Journal: Cancer Research (2012)

Abstract Replication-selective tumor-specific viruses present a novel approach for treating neoplastic disease. These vectors are designed to induce virus-mediated lysis of tumor cells after selective viral propagation within the tumor. Telomerase activation is considered to be a critical step in carcinogenesis, and its activity is closely correlated with human telomerase reverse transcriptase (hTERT) expression. We previously, investigated the antitumor effect of the hTERT-specific replication-competent adenovirus (Telomelysin: OBP-301) on oral squamous cell carcinoma (OSCC) cells in vitro and in vivo orthotopic graft model. OBP-301 replicated efficiently and induced more over 50% cell killing in a panel of human OSCC cell lines, but not in normal human fibroblasts, which were lacking telomerase activity. In orthotopic graft model, intratumoral injection of OBP-301 resulted in a significant inhibition of tumor growth and prolongation of survival. Moreover, OBP-301 in use has limited potency when administered alone; however, combination therapy using these agents and conventional anticancer agents, such as radiation exhibits encouraging levels of efficacy. Here, we describe the mechanistic basis for synergy of irradiation and OBP-301. This combination therapy was more effective compared with OBP-301 alone in OSCC cells. These results illustrate the potential of combining oncolytic virotherapy and ionizing radiation as a promising strategy in the management of human oral cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4976. doi:1538-7445.AM2012-4976
Effect of Nucleoside and Nucleotide Analogues on Renal Function in Patients With Chronic Hepatitis B Virus Monoinfection
Authors: Vincent Mallet, Michaël Schwarzinger, Anaïs Vallet-Pichard, Hélène Fontaine, Marion Corouge, Philippe Sogni, Stanislas Pol
Journal: Clinical Gastroenterology and Hepatology (2014)
Imported African Trypanosomiasis in the United States
Authors: HARRISON C. SPENCER
Journal: Annals of Internal Medicine (1975)

Since 1967, six cases of African trypanosomiasis have been diagnosed and treated in the United States. Five patients were Americans infected with Trypanosoma rhodesiense, and the other was an African student with T. gambiense. Presenting signs and symptoms for all cases were typical of the disease, but often the diagnosis was delayed. The five Americans had spent only brief periods in endemic areas. All cases responded to therapy although one relapsed. Cases of imported sleeping sickness are few, and the risk of Americans acquiring the disease while traveling to endemic areas is low. However, the early diagnosis of sleeping sickness requires that physicians be cognizant of the possibility of imported tropical diseases.
Treatment Received by Depressed Patients
Authors: Martin B. Keller
Journal: JAMA (1982)

We report on the treatment received by 217 patients in the community with a diagnosis of major depressive disorder of at least one month's duration. Only a low proportion of subjects received intensive treatment with antidepressant medication or electroconvulsive therapy, as judged by research standards and current clinical teaching. Specific associations emerge between treatment and several clinical, sociodemographic, and diagnostic variables; however, taken together these variables account for only a small fraction of the variance in treatment received. Even among patient subgroups based on severity and long duration of illness, high proportions did not receive adequate therapeutic trials. Substantial differences are found in treatment across community centers that are not attributable to variation in the clinical characteristics of patients. We conclude that more research is needed to determine how patients and practitioners contribute to this phenomenon of low intensity of somatic treatment. (<i>JAMA</i>1982;248:1848-1855)
Effect of preoperative pain and depressive symptoms on the risk of postoperative delirium: a prospective cohort study
Authors: Cyrus M Kosar, Patricia A Tabloski, Thomas G Travison, Richard N Jones, Eva M Schmitt, Margaret R Puelle, Jennifer B Inloes, Jane S Saczynski, Edward R Marcantonio, David Meagher, M Carrington Reid, Sharon K Inouye
Journal: The Lancet Psychiatry (2014)
Forty years of the NHS. Origins and early development.
Authors: G. Godber
Journal: BMJ (1988)

Details of the structure and organisation of the NHS are on the record, but the reasons underlying the pattern ofits development are less clear.I am concerned here, therefore, mainly with evolutionary changes in the service at work, and I shall keep mainly to the origins and the first 25 years in England and Wales.The real NHS is the many services rendered daily by health professionals and their aides to people in their homes, in health centres, and in hospitals.Three quarters of the population use the NHS each year, and it is by their satisfaction that it should be judged.
Day–Night Variation of Acute Myocardial Infarction in Obstructive Sleep Apnea
Authors: Fatima H. Sert Kuniyoshi, Arturo Garcia-Touchard, Apoor S. Gami, Abel Romero-Corral, Christelle van der Walt, Snigdha Pusalavidyasagar, Tomas Kara, Sean M. Caples, Gregg S. Pressman, Elisardo C. Vasquez, Francisco Lopez-Jimenez, Virend K. Somers
Journal: Journal of the American College of Cardiology (2008)
Cholecystokinin-enhanced cholescintigraphy in the diagnosis of gallbladder disease
Authors: R. M. Gore
Journal: JAMA (1993)

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Sustained viral load and ALT reduction following 48 weeks of entecavir treatment in HBEAG-negative and -positive patients with chronic hepatitis B who have failed prior lamivudine therapy
Authors: R. Gish, T.T. Chang, S. Hadziyannis, J. Cianciara, M. Rizzetto, E. Schiff, G. Pastore, K. Klesczewski, G. Densiky, J. Zhu, D. DeHertogh, R. Hindes
Journal: Journal of Hepatology (2003)
Imaging of the urinary tract
Authors: M A Stott, P H Abrams, F C L Feneley
Journal: BMJ (1988)

insulin to cover meals there is likely to be sufficient B cell failure for continuation ofa sulphonylurea to be of marginal benefit, and it can be withdrawn.Simple guidelines on the use of tablets and insulin4 can cater for most patients until long term studies show a different regimen to be particularly bene- ficial.
Points from Letters: Retired Doctors
Authors: G. R. Thomson
Journal: BMJ (1970)

stuck.We have become, I am afraid, the Cinderella grade of the profession and a mi- nority group the B.M.A. can well afford to neglect.Support for this view is found in the Twelfth Review Body Report, paragraph 99, which states that the Associa- tion claimed that there should be a differential between the top of the scale of medical assistants and the bottom of the scale of consultants.Fortunately, the Review Body, in its wisdom, rejected this.