tbuckley/cabot-search huggingface dataset:
A Woman With an Extremely Premature Infant, 18 Months Later
Authors: Amy N. Ship
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diabetic Microangiopathy and the Control of Blood Glucose
Authors: Marvin D. Siperstein
Journal: New England Journal of Medicine (1983)

With varying degrees of success almost all physicians attempt to maintain approximately normal blood glucose levels in their diabetic patients, in the hope that good control will delay and perhaps prevent the microangiopathic manifestations of diabetes. Nonetheless, as amply demonstrated by conflicting editorials in the Journal 1 , 2 and even more convincingly by the numerous publications on the subject over the past two years, the question whether tight control of blood glucose influences the microvascular complications of diabetes still remains unanswered.If moderate reductions in blood glucose levels were all that were necessary to prevent the clinical manifestations of diabetic microangiopathy, this . . .
A Weak B Antigen, Probably Acquired
Authors: G. M. Giles, A. E. Mourant, D. M. Parkin, J. R. Horley, K. J. Tapson
Journal: BMJ (1959)

l*-6fo'r of t*escases-th.-awtigen-wasprovred to be-inherited FornmagginI -53) ¶ne-'t-ions, i'passming' an Af1witfh-l f inf the' seruw.boat'naodeftifs are gmnr?The two remaining cases 4ok._very-like ouxr seven.The followinist Lakeonfroant Svatstoa4 4ten~t:orr(I958}J..-Case 28.Mrs. R. L appearedwt_ tber rAt .Itc )A antigen-was-normat and 'hr serum cotnamed'an -apparentl' normal anti-B bbt no ant-A-HWr cells were agglultinated& at 162 C. by 13 out of 52 group A sera, and this aggbiunation was inhifi.ed.bykthe salivs-of groupB indirtiduals onty.Her, cells were--not aggiltiniatedby, 36 grotpi A-A-sera.",Case 29.Mr H R atso appeared to be.A,B-? with a .mormalA antigen,and appaireritLy.uormaltanti-Bin.tlhelserum His cells were agglutinatedcy -34-,Ut of 364group,-A-sera at 16' C. The reactions varied from + to + + + in strength and were inhibited by gronp.W"at'vPva -rov His cells were not agglutinrated.by 25group Alera. .The reactisusin this case were stronEge than in the .pi'ecediag..-oe."Dr. Stratton and Dr Rernonn r ve kindly allowed.us to quote further detaig about teiT patrerts Mrs. B. L., -gei 76) (in 1956),, wi8.ltrine fro.i a stranguiated femorai'.herns',one son was A,A the other; appeared.to be 0. but his sample was infected and the results were.not-conusideredfiaaMdyconLusiEve.Mr RH R, d-ied.- in 195&.agedc59,;in' I 4t he.ha caicu a aof the-co1u
Abstract 266: Notch3 is a marker of tumor-propagating cells in non-small cell lung cancer and is required for their self-renewal.
Authors: Yanyan Zheng, Cecile de la Cruz, Leanne Sayles, Chris Alleyne-Chin, Yue Xu, Chuong D. Hoang, Joseph B. Shrager, Erica Jackson, Alejandro Sweet-Cordero
Journal: Cancer Research (2013)

Abstract We investigated tumor cell heterogeneity in mouse models of non-small cell lung cancer (NSCLC) that recapitulate key genetic events in this disease. In tumors driven by simultaneous expression of an oncogenic Kras allele and loss of the tumor suppressor Trp53, only a relatively rare subset of tumor cells is capable of propagating tumor growth in both a clonogenic in vitro assay and an in vivo orthotopic transplantation assay. The tumor-propagating cell (TPC) population was enriched by sorting for the combination of the cell surface markers CD24, ITGB4 and Notch(1-4). We demonstrate a critical and specific role for Notch3 signaling in the maintenance of TPCs in the KrasG12D; Trp53fl/fl mouse model. Knock-down of Notch3, but not Notch 1, 2 or 4, decreased self-renewal of TPCs in vitro. In addition, knock-down of Notch3 was critical for tumor propagation in vivo. The relevance of these studies to human NSCLC was confirmed by demonstrating a significant effect of Notch inhibition on the self-renewal of primary human lung adenocarcinoma cells in ex vivo cultures established directly from patients. These findings identify a novel subpopulation of tumor cells with distinct functional capabilities, underscoring the importance of interrogating heterogeneity in NSCLC. The unique role of Notch3 in tumor propagation may provide a novel therapeutic target for the treatment of non-small cell lung cancer. Citation Format: Yanyan Zheng, Cecile de la Cruz, Leanne Sayles, Chris Alleyne-Chin, Yue Xu, Chuong D. Hoang, Joseph B. Shrager, Erica Jackson, Alejandro Sweet-Cordero. Notch3 is a marker of tumor-propagating cells in non-small cell lung cancer and is required for their self-renewal. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 266. doi:10.1158/1538-7445.AM2013-266
Postoperative Pneumonia after Major Lung Resection
Authors: Olivier Schussler, Marco Alifano, Herve Dermine, Salvatore Strano, Anne Casetta, Sergio Sepulveda, Aziz Chafik, Sophie Coignard, Antoine Rabbat, Jean-François Regnard
Journal: American Journal of Respiratory and Critical Care Medicine (2006)

Postoperative pneumonia (POP) is a life-threatening complication of lung resection. The incidence, causative bacteria, predisposing factors, and outcome are poorly understood.Prospective observational study.A prospective study of all patients undergoing major lung resections for noninfectious disease was performed over a 6-mo period. Culture of intraoperative bronchial aspirates was systematically performed. All patients with suspicion of pneumonia underwent bronchoscopic sampling and culture before antibiotherapy.One hundred and sixty-eight patients were included in the study. Bronchial colonization was identified in 31 of 136 patients (22.8%) on analysis of intraoperative samples. The incidence of POP was 25% (42 of 168). Microbiologically documented and nondocumented pneumonias were recorded in 24 and 18 cases, respectively. Haemophilus species, Streptococcus species, and, to a much lesser extent, Pseudomonas and Serratia species were the most frequently identified pathogens. Among colonized and noncolonized patients, POP occurred in 15 of 31 and 20 of 105 cases, respectively (p = 0.0010; relative risk, 2.54). Death occurred in 8 of 42 patients who developed POP and in 3 of 126 of patients who did not (p = 0.0012). Patients with POP required noninvasive ventilation or reintubation more frequently than patients who did not develop POP (p < 0.0000001 and p = 0.00075, respectively). POP was associated with longer intensive care unit and hospital stay (p < 0.0000001 and p = 0.0000005, respectively). Multivariate analysis showed that chronic obstructive pulmonary disease, extent of resection, presence of intraoperative bronchial colonization, and male sex were independent risk factors for POP.Pneumonia acquired in-hospital represents a relatively frequent complication of lung resections, associated with an important percentage of postoperative morbidity and mortality.
PROGNOSTIC FACTORS IN SCHIZOPHRENIA
Authors: WERNER SIMON, ROBERT D. WIRT
Journal: American Journal of Psychiatry (1961)

Four social history and 12 prognostic factors, reported in the literature to have statistical validity, were studied in this investigation. In addition, personality, historical and demographic data of 80 consecutive first hospital admission patients were compared clinically and statistically during and 1 year following hospitalization. Some factors were prognostic of hospital course, while others were related to longer term adjustment. A clinical comparison utilizing detailed social histories of the most and least improved patients, produced 13 behavior variables, both favorable and unfavorable, which differentiated good and poor prognosis. In addition, the data give empirical support for some theories of etiology in schizophrenia.
Wasting Away
Authors: Ole-Petter R. Hamnvik, Anand Vaidya, Carolyn Becker
Journal: New England Journal of Medicine (2014)

This interactive feature presents the case of a 40-year-old woman with pain, weakness, and poor oral intake. She had had a gradual onset of bilateral flank pain spreading to her lower back, abdomen, and extremities. Test your diagnostic and therapeutic skills at NEJM.org.
NHS must make greater use of information technology
Authors: J. Wise
Journal: BMJ (2008)

The NHS has been slow to adopt technologies that would benefit patients and clinicians, says a report by the King’s Fund, a health think tank.

Technology in the NHS says that patients should be able to routinely use email and the internet to book appointments with their GP, receive routine test results, view medical records, and have online consultations. It also calls for more innovative use of technology, for example, videoconferencing for medical consultations and “virtual visiting” by friends and family.

Alasdair Liddell, coauthor of the report and senior associate at the King’s Fund, told the BMJ , “The NHS appears to be behind other sectors in terms of technology. Many of us now use the internet to bank, shop, and book …
Relationship of binding of a calcium channel blocker to inhibition of contraction in intact cultured embryonic chick ventricular cells.
Authors: J D Marsh, E Loh, D Lachance, W H Barry, T W Smith
Journal: Circulation Research (1983)

To study the mechanism of action of calcium channel-blocking drugs in intact, functioning myocardial tissue under physiological conditions, we related the inhibition of contraction of spontaneously beating monolayers of cultured chick embryo ventricular cells to studies of binding of four calcium channel-blocking drugs to the same preparation under the same physiological conditions. Nitrendipine produced a concentration-dependent decrease in amplitude of contraction (IC50 = 23 nM) as determined by a computer-assisted optical-video system. Studies using [3H]nitrendipine and equilibrium-binding techniques revealed a high affinity binding site in ventricular homogenates (KD = 0.15 nM) and on intact cultured heart cells (KD = 0.26 nM, Bmax = 51 fmol/mg of protein). These dissociation constants are similar to those reported by other workers for ventricular homogenates, but 100-fold lower than the IC50 for the negative inotropic effect in intact cells. Computer analysis of displacement of [3H]nitrendipine by unlabeled nitrendipine yielded a slope factor of 0.76 and identified an additional low affinity binding site for nitrendipine with KD = 19 nM, in good agreement with the IC50 for inhibition of contraction. Verapamil partially interacted with nitrendipine binding, whereas diltiazem showed no interaction. We conclude that, in intact myocardial cells, there are two classes of binding sites for nitrendipine; interaction of dihydropyridines with the low affinity site appears to mediate their effects on contractile function.
Endocannabinoids Shape Accumbal Encoding of Cue-Motivated Behavior via CB1 Receptor Activation in the Ventral Tegmentum
Authors: Erik B. Oleson, Michael V. Beckert, Joshua T. Morra, Carien S. Lansink, Roger Cachope, Rehab A. Abdullah, Amy L. Loriaux, Dustin Schetters, Tommy Pattij, Mitchell F. Roitman, Aron H. Lichtman, Joseph F. Cheer
Journal: Neuron (2012)
Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR
Authors: David Ng, Nalin Thakker, Connie M Corcoran, Dian Donnai, Rahat Perveen, Adele Schneider, Donald W Hadley, Cynthia Tifft, Liqun Zhang, Andrew O M Wilkie, Jasper J van der Smagt, Robert J Gorlin, Shawn M Burgess, Vivian J Bardwell, Graeme C M Black, Leslie G Biesecker
Journal: Nature Genetics (2004)
Acute endotoxemia following transjugular intrahepatic stent-shunt insertion is associated with systemic and cerebral vasodilatation with increased whole body nitric oxide production in critically ill cirrhotic patients
Authors: R. Jalan, S.W.M. Olde Damink, J.C. ter Steege, D.N. Redhead, A. Lee, P.C. Hayes, N.E.P. Deutz
Journal: Journal of Hepatology (2010)
Blanket disapproval of all unlicensed indications is wrong
Authors: S. J. Evans
Journal: BMJ (2011)

Off-label" covers a variety of situations.Applications for marketing authorisations-licences that lead to a "label"-are made by companies for almost entirely commercial reasons.The company that makes bevacizumab does not apply for an authorisation for use in macular degeneration because it also makes the more expensive licensed product.This is a failing of the licensing system, in that it relies on companies to do things in the best interests of patients because these usually coincide with their commercial interests.In this situation, they do not.The General Medical Council and Kyle mistakenly disapprove of all unlicensed indications. 1 If it were open (practically and legally) to the NHS to apply for a marketing authorisation, bevacizumab would probably become licensed for this indication, but with pressure from companies and their allies to prevent this, the opportunity to benefit more patients will be lost.
Digital Arteritis in Rheumatoid Disease
Authors: J. T. Scott, D. O. Hourihane, F. H. Doyle, R. E. Steiner, J. W. Laws, A. St. J. Dixon, E. G. L. Bywaters
Journal: Annals of the Rheumatic Diseases (1961)

Three broad types of vasculitis have been described in rheumatoid arthritis:(1) Subacute lesions of small vessels found in muscles by Sokoloff, Wilens, and Bunim (1951), and in the heart, muscles, and nerve sheaths by Cruickshank (1954).(2) Cases of rheumatoid arthritis complicated by severe widespread necrotizing arteritis affecting large vessels and indistinguishable from polyarteritis nodosa (Aronoff, John-
Cerebral Disorders of Vision in Systemic Lupus Erythematosus
Authors: KENNETH D. BRANDT
Journal: Annals of Internal Medicine (1975)

Sensory neuroophthalmic abnormalities due to cerebral lupus erythematosus, with involvement of visual pathways posterior to the optic chiasm, occurred in 12 patients with systemic lupus erythematosus. Five underwent detailed evaluation because of an hallucination, 4 for visual loss, and 3 for both. Hallucinations were either unformed (for example, bright lights, straight lines) or highly formed (for example, faces), in which case they were invariably recognized by the patient as inappropriate. In no instance did they occur in association with delirium, confusion, or use of hallucinogenic drugs. Patients with loss of vision had scotomas, homonymous field defects, and cortical blindness. These features indicate disease in the posterior cerebral artery circulation, a localization often supported by ancillary neurologic findings, for example, vocal cord paralysis, diminished gag reflex. Thus, various visual dysfunctions may occur in systemic lupus erythematosus due to cerebral vasculitis. At times they may be the most prominent and disabling feature of the disorder.
Troponins in Acute Coronary Syndromes
Authors: Martin J. Quinn, David J. Moliterno
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Action of Manual Making and Team Approach for Using Denosumab in the Bone Metastasis Case
Authors: M. Tamiya, T. Hirashima, Y. Kondo, N. Ryota, K. Iwata, A. Yamato, M. Sando, H. Suzuki, N. Okamoto, I. Kawase
Journal: Annals of Oncology (2013)
The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells
Authors: Liqin Cao, Hiroshi Shitara, Takuro Horii, Yasumitsu Nagao, Hiroshi Imai, Kuniya Abe, Takahiko Hara, Jun-Ichi Hayashi, Hiromichi Yonekawa
Journal: Nature Genetics (2007)
Results of Internal Sphincterotomy for Anal Fissure
Authors: R. C. Bennett, J. C. Goligher
Journal: BMJ (1962)

HYPERPARATHYROIDISMJOjji 9. We need to know more about those patients with primary hyperparathyroidism whose plasma calcium levels fall with cortisone, especially whether they are mostly those who have osteitis fibrosa.10.There seems no simple explanation for the fact that when hyperparathyroidism secondary to renal disease is finally proved to have occurred because of the finding of hyperplastic glands at post-mortem examina- tion these patients always have osteitis fibrosa (Gilmour, 1947).Yet only about 30% of patients with primary hyperparathyroidism, even when of long duration, get osteitis fibrosa.11.The parathyroids in renal disease from sarcoidosis need further study.Our own data and our reading of the literature suggest that secondary hyperpara- thyroidism from this cause is much rarer than should be expected but that " primary "-that is, autonomous tumour formation-hyperparathyroidism occurs more often than can be accounted by chance.12. Patients with parathyroid cancer need further study in case they show a different evolution from patients with adenoma.
Fibroma of the Ovarian Ligament Weighing over Sixteen Pounds: Removal: Recovery
Authors: A. Doran
Journal: BMJ (1889)

been subse- quently put down to anthomyia.Westwood' gives a reference to the Medizin.Corresponden:blatt for 1832 for an account of the occurrence of the larvt of Antho- myia scalaris in man, but I have not been able to look up this reference.
Jejunal Absorption and Secretion of Calcium in Patients with Chronic Renal Disease on Hemodialysis
Authors: Tom F. Parker, Pedro Vergne-Marini, Alan R. Hull, C. Y. C. Pak, John S. Fordtran
Journal: Journal of Clinical Investigation (1974)

10 patients with chronic renal disease on hemodialysis and 8 normals were studied by constant jejunal perfusion of calcium gluconate solutions, using polyethylene glycol as a nonabsorbable marker. Results in normals indicated that calcium absorption from 1 and 5 mM calcium solutions is mainly active. Absorption from 5, 15, and 20 mM solutions was a linear function of luminal calcium concentration, suggesting that the active transport carrier is saturated when luminal calcium concentration is greater than 5 mM and indicating that the increment in absorption at higher luminal concentrations is mainly the result of passive absorption. With 1 mM calcium, normals absorbed calcium against a concentration gradient, whereas the patients secreted calcium. Absorption in the patients was much less than normal with 5, 15, and 20 mM luminal calcium concentrations; however, the slope of this linear (passive) portion of the curve was normal. Unidirectional calcium fluxes were measured with calcium-47. Flux out of the lumen was depressed 2.5-fold in the patients, but flux into the lumen was normal. Xylose, urea, and tritiated water were absorbed normally, indicating no generalized abnormality of jejunal transport in these patients. Endogenous calcium secretion, estimated by the amount of calcium added to a calcium-free solution, was normal in the dialysis patients. These results indicate that active calcium absorption is markedly depressed in patients with chronic renal disease who are receiving hemodialysis therapy. On the other hand, passive calcium movement and endogenous calcium secretions are normal.
Novel intracytoplasmic inclusion bodies in human papillomavirus-associated warts
Authors: T. Mitsuishi, M. Kawashima, K. Egawa, T. Sata
Journal: British Journal of Dermatology (2001)

Journal Article Novel intracytoplasmic inclusion bodies in human papillomavirus‐associated warts Get access T. Mitsuishi, T. Mitsuishi Department of Dermatology, Tokyo Women's Medical University, School of Medicine, 8–1 Kawada‐cho, Shinjuku‐ku, Tokyo 162‐8666, Japan *Department of Dermatology, Kumamoto University School of Medicine, Kumamoto, Japan †Department of Pathology, National Institute of Infectious Diseases, Tokyo, JapanE‐mail: tmitsu@derm.twmu.ac.jp Search for other works by this author on: Oxford Academic Google Scholar M. Kawashima, M. Kawashima Department of Dermatology, Tokyo Women's Medical University, School of Medicine, 8–1 Kawada‐cho, Shinjuku‐ku, Tokyo 162‐8666, Japan *Department of Dermatology, Kumamoto University School of Medicine, Kumamoto, Japan †Department of Pathology, National Institute of Infectious Diseases, Tokyo, JapanE‐mail: tmitsu@derm.twmu.ac.jp Search for other works by this author on: Oxford Academic Google Scholar K. Egawa, K. Egawa Department of Dermatology, Tokyo Women's Medical University, School of Medicine, 8–1 Kawada‐cho, Shinjuku‐ku, Tokyo 162‐8666, Japan *Department of Dermatology, Kumamoto University School of Medicine, Kumamoto, Japan †Department of Pathology, National Institute of Infectious Diseases, Tokyo, JapanE‐mail: tmitsu@derm.twmu.ac.jp Search for other works by this author on: Oxford Academic Google Scholar T. Sata T. Sata Department of Dermatology, Tokyo Women's Medical University, School of Medicine, 8–1 Kawada‐cho, Shinjuku‐ku, Tokyo 162‐8666, Japan *Department of Dermatology, Kumamoto University School of Medicine, Kumamoto, Japan †Department of Pathology, National Institute of Infectious Diseases, Tokyo, JapanE‐mail: tmitsu@derm.twmu.ac.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 1, 1 July 2001, Pages 171–173, https://doi.org/10.1046/j.1365-2133.2001.04308.x Published: 01 July 2001
Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis
Authors: Aditya Murthy, Yang Washington Shao, Swami R. Narala, Sam D. Molyneux, Juan Carlos Zúñiga-Pflücker, Rama Khokha
Journal: Immunity (2012)