tbuckley/cabot-search huggingface dataset:
Recurrence of hepatitis C virus infection after orthotopic liver transplantation
Authors: Paul Martin, Santiago J. Muñoz, Adrian M. Di Bisceglie, Raphael Rubin, Jeanne G. Waggoner, Vincent T. Armenti, Michael J. Moritiz, Bruce E. Jarrell, Willis C. Maddrey
Journal: Hepatology (1991)

Identification of the hepatitis C virus--the main cause of posttransfusion and sporadic non-A, non-B hepatitis--and the development of a diagnostic serological test have allowed us to study possible recurrence of this type of hepatitis after liver transplantation. Six of 34 consecutive transplant recipients were found to have had antibodies to hepatitis C before transplantation. All six patients had possible exposure to hepatitis C through blood transfusion or intravenous drug use. Five of the six patients were positive for antibodies to hepatitis C after 1 yr of follow-up. Two of these patients had clinical and histological evidence of acute viral hepatitis in their allografts. In one patient this led to hepatic injury and dysfunction of two successive grafts. In contrast, none of the twenty-eight patients who were seronegative for hepatitis C virus antibodies before transplantation has converted to seropositivity after transplantation despite perioperative blood transfusions. These results suggest that hepatitis C diagnosed serologically recurs in a minority of transplant recipients and that de novo seroconversion must be uncommon.
A Controlled Trial of Ivermectin and Diethylcarbamazine in Lymphatic Filariasis
Authors: Eric A. Ottesen, V. Vijayasekaran, V. Kumaraswami, S.V. Perumal Pillai, A. Sadanandam, Sheila Frederick, R. Prabhakar, Sriram P. Tripathy
Journal: New England Journal of Medicine (1990)

Ivermectin is a new antifilarial drug that can be given in a single oral dose. To compare the efficacy and side effects of ivermectin with those of diethylcarbamazine, the standard antifilarial treatment, we conducted a randomized, double-blind trial in 40 South Indian men with lymphatic filariasis caused by Wuchereria bancrofti. Patients were randomly assigned to one of three treatments: a single low dose of ivermectin (mean [±SE],21.3±0.7 μg per kilogram of body weight; n = 13) followed by placebo for 12 days; a single high dose of ivermectin (mean, 126.2±3.7 μg per kilogram; n = 13) followed by placebo for 12 days; or diethylcarbamazine for 13 days (6 mg per kilogram per day for 12 days preceded by 3 mg per kilogram for 1 day; n = 14). Eleven patients were initially assigned to receive placebo and after five days were reassigned to one of the three treatment groups.
Use of a durometer to measure the degree of skin induration in lipodermatosclerosis
Authors: Marco Romanelli, Vincent Falanga
Journal: Journal of the American Academy of Dermatology (1995)

Background: Chronic lipodermatosclerosis is characterized by indurated skin on the medial aspect of the leg and is common around venous ulcers. The severity of induration of lipodermatosclerosis has been associated with poor ulcer healing. Clinical assessment of lipodermatosclerosis presently relies on a clinical skin severity score adapted from studies of patientswith systemic sclerosis. Objective: It would be desirable for prognostic reasons to develop an objective method for measuring skin hardness in lipodermatosclerosis. Methods: The degree of skin induration at the midpoint between the upper and lower margin of lipodermatosclerosis in 30 sequential nonselected patients with lipodermatosclerosis was assessed by a blinded observer's clinical score and by quadruplicate determinations with a hand-held type O durometer. Skin induration on the medial aspect of the leg was similarly measured in five normal volunteers. Transcutaneous oxygen pressure was measured at the same sites. Results: A direct linear relation (r = 0.962) was found between skin severity scores and durometer readings (p < 0.01). A clinical skin score of 2 reflected a higher durometer reading compared with a skin score of 1 (p = 0.0016) and, similarly, higher durometer readings were found in skin score of 3 compared with score 2 skin (p = 0.0093). Transcutaneous oxygen pressure was uniformly reduced in lipodermatosclerosis (p < 0.02). Conclusion: The durometer is a reliable instrument for measuring skin hardness in patients with lipodermatosclerosis. It may be used to test the prognostic value of lipodermatosclerosis on ulcer healing.
Transcriptome and proteome quantification of a tumor model provides novel insights into post‐transcriptional gene regulation
Authors: Christoph Jüschke, Ilse Dohnal, Peter Pichler, Heike Harzer, Remco Swart, Gustav Ammerer, Karl Mechtler, Juergen A Knoblich
Journal: Genome biology (2013)

Abstract Background Genome‐wide transcriptome analyses have given systems‐level insights into gene regulatory networks. Due to the limited depth of quantitative proteomics, however, our understanding of post‐transcriptional gene regulation and its effects on protein‐complex stoichiometry are lagging behind. Results Here, we employ deep sequencing and the isobaric tag for relative and absolute quantification (iTRAQ) technology to determine transcript and protein expression changes of a Drosophila brain tumor model at near genome‐wide resolution. In total, we quantify more than 6,200 tissue‐specific proteins, corresponding to about 70% of all transcribed protein‐coding genes. Using our integrated data set, we demonstrate that post‐transcriptional gene regulation varies considerably with biological function and is surprisingly high for genes regulating transcription. We combine our quantitative data with protein‐protein interaction data and show that post‐transcriptional mechanisms significantly enhance co‐regulation of protein‐complex subunits beyond transcriptional co‐regulation. Interestingly, our results suggest that only about 11% of the annotated Drosophila protein complexes are co‐regulated in the brain. Finally, we refine the composition of some of these core protein complexes by analyzing the co‐regulation of potential subunits. Conclusions Our comprehensive transcriptome and proteome data provide a valuable resource for quantitative biology and offer novel insights into understanding post‐transcriptional gene regulation in a tumor model.
The war is over
Authors: C. Douglas
Journal: BMJ (1995)

The dinner in honour of our guest is an impromptu one. There is no special menu and only a very restrained presence of mess silver. And since anything other than lounge suits would certainly embarrass him, lounge suits it is. He is tall and slightly stooped, with a faint air of ascetic elation, perhaps that of a bishop on holiday. He has arrived that morning on a Ministry of Defence flight from Moscow carrying, it is said, only a plastic bag.

In an informal way he is some kind of official visitor—his travel taken care of, accommodation arranged with a senior officer in our establishment. The background is unusual and intriguing, something between an East-West scientific link …
Collagenous colitis in adult Sri Lankans: experience from the Indian subcontinent
Authors: R L Satarasinghe
Journal: Gut (2006)

mortality rate less than 1%.Our series confirmed that ''explosive HCC spread'' may occur after RFTA, with no correlation with AFP, or differentiation or location of the tumour, and frequently even after total ablation.Why do these patients develop this severe (and dramatic if observed in patients on waiting lists for orthotopic liver transplantation) 8 and unexpected complication and what is its prevalence?Whether or not we can identify patients at risk is open to discussion, which we believe should be exhaustive before abandoning PEI as obsolete in favour of RFTA as the treatment of choice for early disease not eligible for surgery.Let us
Dendritic Cell Expression of the Signaling Molecule TRAF6 Is Critical for Gut Microbiota-Dependent Immune Tolerance
Authors: Daehee Han, Matthew C. Walsh, Pedro J. Cejas, Nicholas N. Dang, Youngmi F. Kim, Jihyun Kim, Laetitia Charrier-Hisamuddin, Lillian Chau, Qin Zhang, Kyle Bittinger, Frederic D. Bushman, Laurence A. Turka, Hao Shen, Boris Reizis, Anthony L. DeFranco, Gary D. Wu, Yongwon Choi
Journal: Immunity (2013)
Pulse wave reflection: can it explain the differences between systemic and pulmonary pressure and flow waves? A study in dogs.
Authors: G C van den Bos, N Westerhof, O S Randall
Journal: Circulation Research (1982)

We have studied the effect of changes in pulse wave reflection on the configurations of pressure and flow in systemic and pulmonary circulation. Electromagnetic flow transducers, atrial catheters, and pacing leads were implanted in 10 dogs. In four animals, the flow transducer was placed on the pulmonary artery, in another four on the ascending aorta, and in two additional dogs on both vessels. One week later, ascending aortic and/or pulmonary artery flow and pressure (catheter tip manometer) were measured under general anesthesia (Nembutal, 30 mg/kg, iv). When the pulmonary circulation was studied (six dogs), measurements were made before and during serotonin infusion (0.5-0.75 mg/min). When the systemic circulation was studied (six dogs), measurements were made before and during nitroprusside infusion (50-200 micrograms/min). To quantify the arterial load, we calculated pulmonary and systemic input impedances. To estimate the amount of reflection, we used a reflection index which we defined as the amplitude ratio of reflected and forward wave. Nitroprusside decreased total peripheral resistance, increased total arterial compliance, and decreased the reflection index; similarity between aortic pressure and flow wave shapes increased, and they looked more like their pulmonary counterparts. Serotonin increased pulmonary vascular resistance, decreased pulmonary arterial compliance, and increased the reflection index. Resemblance of pressure and flow waves decreased. The differences in wave shapes can thus be explained by the amount of reflection: the less reflection the more pressure and flow resemble each other.
65 SAFETY OF TRIPLE THERAPY WITH TELAPREVIR OR BOCEPREVIR IN HEPATITIS C PATIENTS WITH ADVANCED LIVER DISEASE – PREDICTIVE FACTORS FOR SEPSIS
Authors: K. Rutter, A. Ferlitsch, A. Maieron, A.F. Stättermayer, I. Graziadei, M. Dulic, M. Gschwantler, R. Stauber, H. Hofer, M. Peck-Radosavljevic, W. Vogel, M. Trauner, P. Ferenci
Journal: Journal of Hepatology (2013)
Intramural Lesion of Esophagus
Authors: Frank J. Gallia
Journal: JAMA (1968)

Dr. Richard M. Heller: This was the first hospital admission of this 48-year-old woman. Two years ago she began to complain of vague substernal discomfort, made worse by eating spicy foods. She was, however, able to swallow solids without difficulty. Results of physical examination and laboratory studies were within normal limits. Barium study of the upper gastrointestinal tract was performed (Figure). <h3>Discussion</h3> Dr. Laurence L. Robbins: How would you interpret these roentgenograms, Dr. Dreyfuss? Dr. Jack R. Dreyfuss: There is a crescentshaped pressure defect against the column of barium in the lower portion of the esophagus, very suggestive of an intramural, extramucosal tumor. The leading diagnostic possibility would be spindle-cell tumor. However, there are other entities that can look like this. It is conceivable that a mediastinal lymph node is pressing against the esophagus. It is also possible that there is a duplication or an enteric cyst of the lower
Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells
Authors: Natasha K. Crellin, Sara Trifari, Charles D. Kaplan, Tom Cupedo, Hergen Spits
Journal: The Journal of Experimental Medicine (2010)

Lymphoid tissue inducer (LTi) cells are required for lymph node formation during fetal development, and recent evidence implies a role in mucosal immunity in the adult. LTi cells share some phenotypic features of conventional natural killer (NK; cNK) cells; however, little is known to date about the relationship between these two cell types. We show that lineage(-) (Lin(-)) CD127(+)RORC(+) LTi-like cells in human tonsil are precursors to CD56(+)CD127(+)RORC(+)NKp46(+) cells, which together comprise a stable RORC(+) lineage. We find that LTi-like cells and their CD56(+) progeny can be expanded and cloned ex vivo without loss of function and without conversion into cNK cells. Clonal analysis reveals heterogeneity of cytokine production within the CD127(+) LTi-like population. Furthermore, we identify within the tonsil a cNK precursor population that is characterized as Lin(-)CD117(+)CD161(+)CD127(-) cells. Overall, we propose that CD127(+)RORC(+) cells, although they share some characteristics with cNK cells, represent a functionally and developmentally distinct lineage.
Bradykinin stimulation of oxidative metabolism in renal cortical tubules from rabbit. Possible role of arachidonic acid.
Authors: P C Brazy, D R Trellis, P E Klotman
Journal: Journal of Clinical Investigation (1985)

Vasoactive peptides may have direct effects on both renal vasculature and renal tubules. In this study, we examined the direct and immediate effects of bradykinin on oxygen consumption by suspensions of cortical tubules from rabbit kidney. Bradykinin (10(-11) to 10(-7) M) stimulated oxygen consumption rates (QO2) in a dose-dependent manner with a maximal increase of +0.80 +/- 0.13 nmol X mg protein-1 X min-1. This stimulation was prevented by calcium-free media or by the addition of inhibitors of calcium transport, calcium-calmodulin complex formation, Na,K-ATPase activity, mitochondrial respiration, and phospholipase activity. Addition of bradykinin increased the ADP and AMP contents of cortical tubules without changing the ATP content. These data indicate that bradykinin stimulates ATP use and Na,K-ATPase activity. We also examined the effects of exogenous arachidonic acid on QO2 in cortical tubules. Acute additions of arachidonic acid stimulated QO2 at low concentrations (10(-8) to 10(-6) M) and uncoupled mitochondrial respiration at high concentrations (10(-5) M). The effect of arachidonic acid on adenosine nucleotide content was dose-dependent and indicated increased use of ATP. Bradykinin increased QO2 in the presence of low concentrations of arachidonic acid (10(-11) to 10(-9) M), but had no further effect on QO2 in the presence of higher concentrations of arachidonic acid (10(-8) to 10(-6) M). Bradykinin stimulation of QO2 was not prevented by inhibition of cyclooxygenase activity with indomethacin but was prevented by inhibition of lipoxygenase-like activity with nordihydroguariaretic acid. These results suggest that the bradykinin effect on QO2 may be mediated by arachidonic acid release and subsequent metabolism.
Imrich (“Emery”) Sarkany
Authors: Robin Graham-Brown
Journal: BMJ (2007)

Imrich Sarkany (“Emery” but known as “IS” at the Royal Free) was a remarkable man, who overcame difficulties most of us can barely imagine to build a highly successful career as one of Britain's leading dermatologists. The son of a vet, born in Slovakia, his life was severely disrupted by the upheavals created by Hitler and Stalin. Before the outbreak of hostilities he was sent by his mother to safety in England, where he enrolled in the Czech brigade of the British Army. On returning to Czechoslovakia after the second world war, he discovered that his whole family had been lost in the Holocaust: he was on his own. Amazingly, a few years before Emery died, he became reacquainted with the history of his home and its 25 Jewish families, of whom only he and one other had survived. These two created a memorial to the lost Jews of Svati Jur, and Emery went back, fortunately still well enough to make a speech at the opening. 

Dr Sarkany began his medical studies at Prague's Charles' University but, with the advent of the Communist regime, he slipped …
Confluent and reticulated papillomatosis associated with atopy. Successful treatment with topical urea and tretinoin
Authors: M.K. Kägi, R. Trüeb, B. Wüthrich, G. Burg
Journal: British Journal of Dermatology (1996)

Journal Article Confluent and reticulated papillomatosis associated with atopy. Successful treatment with topical urea and tretinoin Get access M.K. Kägi, M.K. Kägi Department of Dermatology, University Hospital Zürich, Gloriastr. 31, CH‐8091 Zürich, Switzerland Search for other works by this author on: Oxford Academic Google Scholar R. Trüeb, R. Trüeb Department of Dermatology, University Hospital Zürich, Gloriastr. 31, CH‐8091 Zürich, Switzerland Search for other works by this author on: Oxford Academic Google Scholar B. Wüthrich, B. Wüthrich Department of Dermatology, University Hospital Zürich, Gloriastr. 31, CH‐8091 Zürich, Switzerland Search for other works by this author on: Oxford Academic Google Scholar G. Burg G. Burg Department of Dermatology, University Hospital Zürich, Gloriastr. 31, CH‐8091 Zürich, Switzerland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 134, Issue 2, 1 February 1996, Pages 381–382, https://doi.org/10.1111/j.1365-2133.1996.tb07644.x Published: 01 February 1996
Stimulation of heme oxygenase in macrophages and liver by endotoxin.
Authors: D Gemsa, C H Woo, H H Fudenberg, R Schmid
Journal: Journal of Clinical Investigation (1974)

In rat peritoneal macrophages, engaged in erythrophagocytosis in vitro, endotoxin stimulated heme oxygenase (HO) activity, which was additive to the substrate-mediated enzyme induction produced by the ingested erythrocyte hemoglobin. Endotoxin neither appeared to injure the erythrocytes, nor did it enhance the rate of erythrophagocytosis. In intact rats, HO activity in both parenchymal and sinusoidal cells of the liver was increased after treatment with endotoxin. It is likely that endotoxin directly stimulates HO activity, a process which may account for the reported rise in bilirubin formation in endotoxin-treated animals. The effect of endotoxin on HO may represent part of the general activation of phagocytic cells by endotoxin.
Book Review AIDS and Contemporary History (Cambridge History of Medicine.) Edited by Virginia Berridge and Philip Strong. 284 pp. New York, Cambridge University Press, 1993. $54.95. 0-521-41477-6 AIDS: The Winter War By Arthur D. Kahn. 236 pp. Philadelphia, Temple University Press, 1993. $27.95. 1-55639-018-4
Authors: Ronald Bayer
Journal: New England Journal of Medicine (1994)
Long-term outcome for 120 Japanese patients with Takayasu's disease. Clinical and statistical analyses of related prognostic factors.
Authors: K Ishikawa, S Maetani
Journal: Circulation (1994)

BACKGROUND Patients with Takayasu's disease, a chronic inflammatory arteriopathy of unknown cause, have variable clinical courses, and predictors of the long-term outcome are not well understood. We studied prognostic factors of this disease, based on follow-up results, and a new prognostic classification was proposed. METHODS AND RESULTS Life-table methods and Cox regression analyses were applied to clinical data on 120 patients who had been prospectively followed for a median of 13 years (range, 1 month to 34 years). The overall survival rate at 15 years after the diagnosis was 82.9% and remained the same for the remainder of the follow-up period. Univariate Cox analyses revealed that of the six dichotomous variables evaluated at diagnosis, four were statistically significant predictors, including complications (Takayasu's retinopathy, hypertension, aortic regurgitation, and aneurysm), pattern of the past clinical course, age of the patient, and calendar year of diagnosis. Thus, the 15-year survival was 66.3% versus 96.4% for patients with and without a major complication, 67.9% versus 92.9% for patients with and without a progressive course, 58.3% versus 92.7% for age &gt; 35 years and &lt; or = 35 years, and 79.9% versus 96.5% for patients diagnosed in 1957 through 1975 and in 1976 through 1990, respectively. The delay in diagnosis and the erythrocyte sedimentation rate (ESR) were of marginal significance. The multivariate Cox analysis showed that only two of the above variables were statistically independent predictors, ie, the major complication and the progressive course. In addition to these two factors, ESR was the third predictor, if the Cox stepwise elimination procedure was performed. These three predictors used in various combinations made a total of 1822 classifications theoretically feasible. Of these, a three-stage classification was selected as the best one, based on the Akaike information criterion. The presence of both major complication and progressive course (stage 3) was the worst prognostic indicator (43% survival at 15 years). In contrast, no patient died who had neither of these manifestations or who had a progressive course but an elevated ESR as well (stage 1). CONCLUSIONS The long-term outcome for patients with Takayasu's disease seems best predicted by two major prognostic factors, ie, complications and the pattern of the past clinical course, as well as by ESR. Aggressive medical and surgical treatment may be considered for patients with a major complication and a progressive course (stage 3).
MUC2 is the prominent colonic mucin expressed in ulcerative colitis.
Authors: K M Tytgat, F J Opdam, A W Einerhand, H A Buller, J Dekker
Journal: Gut (1996)

BACKGROUND--It has been shown that MUC2 is the prominent mucin synthesised in healthy colon. AIM--To identify the predominant mucins in ulcerative colitis (UC) and to study their biosynthesis. METHODS AND RESULTS--Mucin was purified from UC resection specimens. This mucin on sodium dodecylsulphate polyacrylamide gel electrophoresis (SDS-PAGE) presented as one, high molecular weight, periodic acid/Schiff's reagent (PAS) stainable band. Amino acid composition showed a close resemblance to that of MUC2. Immunoprecipitation with a specific anti-MUC2 antiserum confirmed that this mucin was MUC2. In addition, on the mRNA level MUC2 was also the most prominent mucin expressed in UC. Polyclonal antiserum was elicited, mainly recognising mucin peptide epitopes of UC and normal colonic mucin. Biosynthetic studies with [35S]amino acids showed that the MUC2-precursor in UC displayed a molecular mass on SDS-PAGE of approximately 600 kDa. This precursor was converted into a mature MUC2 with anomalous mobility on SDS-PAGE of 550 kDa and was secreted. Only this 550 kDa band could be labelled with [35S]sulphate and stained by PAS. CONCLUSIONS--This study shows that in parallel with the mucin expression in healthy controls, MUC2 is the major mucin expressed in UC. Qualitatively, MUC2 biosynthesis seems unchanged in UC.
The effects of pimecrolimus on the innate immune response in atopic dermatitis
Authors: S.G. Danby, M.J. Cork
Journal: British Journal of Dermatology (2013)

Journal Article The effects of pimecrolimus on the innate immune response in atopic dermatitis Get access S.G. Danby, S.G. Danby Academic Unit of Dermatology Research, Department of Infection and Immunity, Faculty of Medicine, Dentistry and Health, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, U.K Search for other works by this author on: Oxford Academic Google Scholar M.J. Cork M.J. Cork Academic Unit of Dermatology Research, Department of Infection and Immunity, Faculty of Medicine, Dentistry and Health, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, U.KDepartment of Dermatology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals Trust, Sheffield, U.KPaediatric Dermatology Clinic, Sheffield Children’s Hospital, Sheffield, U.K. Correspondence: Michael J Cork E‐mail: m.j.cork@sheffield.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 168, Issue 2, 1 February 2013, Pages 235–236, https://doi.org/10.1111/bjd.12154 Published: 01 February 2013