tbuckley/cabot-search huggingface dataset:
Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation
Authors: Shinya U. Amano, Jessica L. Cohen, Pranitha Vangala, Michaela Tencerova, Sarah M. Nicoloro, Joseph C. Yawe, Yuefei Shen, Michael P. Czech, Myriam Aouadi
Journal: Cell Metabolism (2014)
Methylenetetrahydrofolate reductase gene (<i>MTHFR</i>) polymorphisms and reduced risk of malignant lymphoma
Authors: Keitaro Matsuo, Nobuyuki Hamajima, Ritsuro Suzuki, Michinori Ogura, Yoshitoyo Kagami, Hirofumi Taji, Tetsuo Yasue, Nancy E. Mueller, Shigeo Nakamura, Masao Seto, Yasuo Morishima, Kazuo Tajima
Journal: American Journal of Hematology (2004)

Abstract Folate and methionine are important nutrients in the “one‐carbon” metabolism that is closely associated with DNA synthesis and DNA methylation. Genetic variation in these pathways may change susceptibility to cancer development. We have previously reported associations between lymphoma risk and germline polymorphisms in genes of methylenetetrahydrofolate reductase ( MTHFR C677T and A1298C) and methionine synthase ( MTR A2756G), finding the genotype other than the MTHFR 677CC / 1298AA to confer a half‐risk compared to the MTHFR 677CC / 1298AA and a 3‐fold higher risk with the MTR GG genotype than the AA / AG genotypes. To confirm the association and explore the histological difference, we extended the previous case series. A case‐control study was conducted in Japan with a total of 372 lymphoma cases and 500 noncancer controls examined for genotypes. The relative risks were estimated by unconditional logistic regression analysis. In overall analyses, the age–sex adjusted odds ratio (OR) for the subjects harboring MTHFR 677T or 1298C alleles relative to 677CC/1298AA genotype was 0.58 (95% confidence interval: 0.41–0.83, P = 0.002). The MTR GG genotype showed an OR of 1.75 (0.87–3.52, P = 0.114). These findings were validated in separate analyses of the 273 new incident cases. Subgroup analyses according to histological subtype [diffuse large B‐cell lymphoma (DLB), follicular lymphoma (FL), low‐grade lymphoma of mucosa associated lymphoid tissue (MALT), and others] illustrated similar associations with certain exceptions for FL and MALT. Our data showed an association between the MTHFR polymorphisms and malignant lymphoma risk for all histological subtypes, although the extent of contribution of these polymorphisms may differ somewhat with histological subtype. Lack of association with MTR polymorphism was also confirmed. Am. J. Hematol. 77:351–357, 2004. © 2004 Wiley‐Liss, Inc.
Lithium and Lupuslike Syndrome
Authors: Vikram R. Shukla
Journal: JAMA (1982)

<h3>To the Editor.—</h3> A common side effect associated with lithium carbonate administration is a rash, possibly related to lithium's action on immunologic function.<sup>1</sup>In this regard, lithium has been suggested to be a potential causative agent for drug-induced lupus erythematosus.<sup>2</sup>We present a case report demonstrating the association between lithium administration and a lupuslike syndrome. <h3>Report of a Case.—</h3> A 44-year-old woman was admitted to the hospital for recurrent unipolar depression with suicidal ideation after ingesting 150 mg of desipramine hydrochloride in a suicide attempt. She had a history of thyroid surgery, spastic colitis, fissure in ano, and bronchial asthma. She had received tricyclic antidepressants in the past, including imipramine hydrochloride and desipramine. She had a history of allergy to sulfonamides, tetanus antiserum, and citrus fruits. At admission, physical examination findings were normal and no dermatologic abnormalities were noted; all laboratory test results were within normal limits. Her
BRL 1621: A Comparison with Other Isoxazolyl Penicillins
Authors: R. Knox, D. M. MacLaren, J. T. Smith, J. A. P. Trafford, R. D. S. Barnes
Journal: BMJ (1962)

INSULINOMATABcuu 831 be extended to 72 hours before organic hyperinsulinism can be confidently excluded.Happily, there is reason to believe that patients might be spared these marathon fasts by combining starvation with muscular activity (see Case 5-Morley, 1952).The presence of organic hyperinsulinism can be confidently inferred if the requirements of Whipple's (1938) triad are fulfilled.These are: the advent of neuropsychiatric symptoms after fasting; a concomitant blood-sugar level below 50 mg./100ml.; and banish- ment of symptoms by the administration of glucose. SummaryThe literature relating to endogenous hypoglycaemia is briefly reviewed.Two cases of hypoglycaemia due to insulinomata of the pancreas are described, mental symptoms so dominating the clinical picture that the patients were admitted to psychiatric hospitals.The abolition of all symptoms by successful operations for the removal of the tumours are recorded.Points of particular interest in the case reports are commented upon, and the differential diagnosis of hypoglycaemia is discussed.We regret that shortage of space prevents our thanking all those to whom we are indebted for assistance with these cases, but we are especially grateful for the help we have received from
Correction: Immunization Policies and Vaccine Coverage among Adults: The Risk for Missed Opportunities
Authors: Walter W. Williams
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 August 1988Correction: Immunization Policies and Vaccine Coverage among Adults: The Risk for Missed OpportunitiesWalter W. Williams, MD, MPHWalter W. Williams, MD, MPHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-4-348_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:There was an error in Figure 1 of the article "Immunization Policies and Vaccine Coverage Among Adults: The Risk for Missed Opportunities" (1). The curve for high-risk persons 65 years of age and older was incorrectly shifted upward about 10 percentage points....Reference1. Williams W, Hickson M, Kane M, Kendal A, Spika J, and Hinman A. Immunization policies and vaccine coverage among adults: the risk for missed opportunities. Ann Intern Med. 1988;108:616-25. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Walter W. Williams, MD, MPHAffiliations: Centers for Disease Control Atlanta, GA 30333 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 1988Volume 109, Issue 4Page: 348-348KeywordsVaccines ePublished: 1 December 2008 Issue Published: 15 August 1988 PDF downloadLoading ...
Medicine as a Science: Obstetrics
Authors: Frederick C. Irving
Journal: New England Journal of Medicine (1951)

THE obstetrician occupies an unusual place in the practice of medicine. Most of his patients are not sick, but are performing the natural function of reproduction. If this function were always normal his cares would be few indeed, but complications and accidents may occur suddenly and with disquieting frequency. He must also be a surgeon, an internist and, on occasions, a pediatrician. His work demands the most meticulous aseptic technic, his patients may suffer from any medical ailment, and he has the first opportunity to detect disease or abnormality in the newborn infant. These are the factors that make his . . .
European register of patients with sickle cell disease treated with hydroxyurea is being set up
Authors: S. C Davies, M. Roberts-Harwood
Journal: BMJ (1998)

EDITOR—In 1995 Charache et al showed conclusively in the United States that hydroxyurea ameliorates the clinical consequences of sickle cell disease in most patients.1There is no biological reason to expect greatly different results in Britain. Moreover, there has not been any serious discussion at any meetings of European or North American experts that has been in support of repeating the study. Doing so is not warranted from either the research or cost perspectives.

We were therefore surprised to read the editorial by Olujohungbe …
872-5 Incidence of diastolic dyssynchrony in dilated cardiomyopathy and effects of biventricular pacing
Authors: Christophe Jego, Iris Schuster, Christine Medall, Jean Lefevre, Frederic Franceschi, Jean-Marie Vailloud, Ange Ferracci, Jean-Claude DeHaro, Pierre Dijane, Gilbert H Habib
Journal: Journal of the American College of Cardiology (2004)
Diurnal variation in incidence of stroke: Oxfordshire community stroke project.
Authors: S. J. Wroe, P. Sandercock, J. Bamford, M. Dennis, J. Slattery, C. Warlow
Journal: BMJ (1992)

To determine whether diurnal variation occurs in the onset of stroke.Community based study over four years.Oxfordshire, United Kingdom.105,000 people, of whom 675 had a first ever stroke. 545 had a cerebral infarction, 66 had primary intracerebral haemorrhage, 33 had subarachnoid haemorrhage, and in 31 the type of stroke was not known.Time of stroke and degree of activity at onset.In the 578 patients for whom it was known whether onset occurred while asleep or awake, the proportion with onset during sleep was 25% (135/545) for cerebral infarction, 17% (11/66) for primary intracerebral haemorrhage, and 0% (0/33) for subarachnoid haemorrhage. This difference persisted if patients in whom it was not known whether they were asleep or awake at onset were classed as asleep. For all stroke types together there was a significant (chi 2 = 218.7, p less than 0.001) diurnal variation with a morning peak between 0800 and 1000, which persisted even after allowing for strokes first noted on waking by redistributing the hour of onset through the preceding eight hours (chi 2 = 47, p less than 0.001). A significant diurnal variation was also found in the onset of cerebral infarction (peak 0800-1000, chi 2 = 208.4, p less than 0.001). Fewer patients had other forms of stroke and the diurnal variations for primary intracerebral haemorrhage (peak 1000-1200) and subarachnoid haemorrhage (peaks 0800-1000 and 1800-2000) were not significant. There seemed to be a second smaller peak for all types of stroke.All types of stroke are most likely to occur after waking in the morning. The cause of the circadian variation requires further study.
THE PREHALLUX IN RELATION TO FLATFOOT
Authors: F. C. KIDNER
Journal: JAMA (1933)

In 1929 I<sup>1</sup>described an operation for the correction of certain cases of intractable flatfoot by the removal of the prehallux or accessory scaphoid and transplantation of the posterior tibial tendon. In that article the literature was reviewed and a bibliography given. It was stated that the prehallux is a common and frequently unrecognized anomaly which, by changes in leverage, interferes with the normal mechanics of the action of the posterior tibial muscle and thus produces weakness of the longitudinal arch and flatfoot of a type highly resistant to the usual conservative methods of treatment. It was also stated that in the presence of the prehallux, whether as a separate bone or as a prolongation inward of the scaphoid, there is an abnormal insertion of the tibialis posticus tendon. Instead of passing under the inner end of the scaphoid to insert in the lower surface of the two internal
"Super A's" and Counseling
Authors: ALBERT OBERMAN
Journal: Annals of Internal Medicine (1975)

Comments and Corrections1 March 1975"Super A's" and CounselingALBERT OBERMAN, M.D., M.P.H., GLENN H. HUGHES, PH.D.ALBERT OBERMAN, M.D., M.P.H.Search for more papers by this author, GLENN H. HUGHES, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-3-431_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dr. Blankenhorn and associates suggest in the NovemberAnnals(81:700, 1974) a program for selecting paramedical individuals on the basis of specific personality attributes ("Type A- or B + ") in order to counterbalance Type "Super A" physicians who, in risk-factor counseling, might be impatient and set unrealistic goals for Type B patients. They believe a "negative set" for risk reduction will occur from the interaction between "Super A" physicians and "B" patients. The basis for this grand suggestion is the discovery that physicians studied by Dr. Jenkins at a "Three Days in Cardiology" course were "Super... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Medical Center Heart Evaluation Clinic School of Medicine The University of Alabama University Station Birmingham, Alabama 35294 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1975Volume 82, Issue 3Page: 431-432 Issue Published: 1 March 1975 PDF downloadLoading ...
Abstract OT1-1-12: NSABP FB-7 Trial: A Phase II Randomized Clinical Trial Evaluating Neoadjuvant Therapy Regimens with Weekly Paclitaxel and Neratinib or Trastuzumab or Neratinib and Trastuzumab Followed by Doxorubicin and Cyclophosphamide with Postoperative Trastuzumab in Women with Locally Advanced HER2-Positive Breast Cancer
Authors: J Lu, SA Jacobs, ME Buyse, S Paik, N Wolmark
Journal: Cancer Research (2012)

Abstract Neratinib is an oral, small molecule which acts as an irreversible inhibitor of the pan ErbB receptor tyrosine kinase. Dual ErbB blockade combined with chemotherapy improves efficacy in Her-2 positive breast cancer. Both NeoALTTO (Lancet 2012) and Neosphere (Lancet Oncol 2012) trials demonstrated higher pCR for Her-2 positive breast cancer receiving dual anti-Her-2 neoadjuvant blockade therapy. The purpose of this trial is to determine the activity and safety profile of Neratinib as mono-blockade or in combination with Trastuzumab as dual blockade in neoadjuvant therapy of locally advanced breast cancer (stage IIB, III A, B and C). Methods: This NSABP Foundation Research Program study (FB-7) is designed as a Phase II, multi-center, three arm clinical trial for patients with Her-2 positive locally advanced breast cancer. 126 patients will be enrolled. The initial two- arm study of Neratinib or Trastuzumab in combination with Paclitaxel began in December 2010. 30 patients were enrolled by December of 2011 at which time the study was placed on hold awaiting the recommended phase II dose of the three drug combination, Neratinib, Trastuzamab and Paclitaxel (NSABP FB-8 trial), which is a Phase I dose-escalation study in women with metastatic Her-2 positive breast cancer. The amended FB −7 trial is now a three arm trial of weekly Paclitaxel and Neratinib or Trastuzumab or Neratinib and Trastuzumab for 4 cycles followed by Doxorubicin and Cyclophosphamide for 4 cycles prior to surgical resection. Patients will then receive postoperative Trastuzumb to complete one total year of Her-2 blockade therapy. The primary goal of this study is to determine the pathologic complete response in breast and axillary lymph nodes following completion of neoadjuvant therapy. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr OT1-1-12.
STUDIES ON THE FACTORS ESSENTIAL TO THE INITIATION AND MAINTENANCE OF MULTIPLICATION OF PSITTACOSIS VIRUS (6BC STRAIN) IN DEFICIENT CELLS IN TISSUE CULTURE
Authors: John D. Hare, Herbert R. Morgan
Journal: The Journal of Experimental Medicine (1954)

The growth of psittacosis virus (6BC) was studied in cultures of minced whole chick embryo tissue maintained in either Hanks-Simms solution or Hanks's balanced salt solution (BSS), and in neither medium could sustained, long-term virus growth take place. Addition of beef embryo extract (BEE) to cultures at a time when virus multiplication was declining reversed this general trend and resulted in greater virus growth. This virus-stimulating action of BEE was only partially diminished by colchicine, a mitotic inhibitor, indicating that the action of BEE was not due entirely to the development of a larger population of cells as a result of its enhancement of cell proliferation. Chick embryo tissue cultivated for 13 days in BSS prior to infection lost its ability to support the growth of psittacosis virus, but this capacity could be restored by the addition of BEE, alone or with colchicine, at the time of infection. A significant amount of virus was adsorbed to tissue in BSS alone, indicating that the failure of virus to grow in depleted tissue maintained only in BSS after infection was not due entirely to failure of virus to attach to and invade the cells. It was found that an ultrafiltrate and a dialysate of BEE contained the major part of the stimulating capacity of the whole extract, indicating that the active materials were substances of low molecular weights. Autoclaved lactalbumin hydrolysate was an active stimulator, suggesting that the materials responsible for its activity were relatively heat-stable. Since a chemically defined medium (Parker 199) was equally effective in stimulating viral growth, it should be possible eventually to define the chemical nature of the virus stimulators. The implications of the findings are discussed with special reference to their application in the study of tissue tropisms and of latency in viral infections of cells.
Argentina running out of medical supplies
Authors: S. Arie
Journal: BMJ (2002)

Argentina's hospitals and pharmacies are running out of medical supplies and bracing themselves for rising drug prices as the bankrupt country sinks deeper into economic crisis.

“We are facing true chaos. It is unprecedented. There is no medication or treatments,” Juan Carr, who heads Red Solidaria (Solidarity Network), a non-governmental community support organisation, told local media.

Some hospitals have been forced to turn patients away as they run out of basic supplies such as syringes and gauze. Red Solidaria has called on the Argentine people to pool whatever stores of drugs they have for patients with AIDS, cancer, and organ transplants, who need specific drugs to stay alive. Brazil recently donated 275 000 doses of …
Gallium Scintigraphy in Neoplastic Angioendotheliosis of the Lung
Authors: NORINARI HONDA, KIKUO MACHIDA, TSUYOSHI KAMANO, TOSHIO MAMIYA, TAKU TAKAHASHI, TERUO TAKISHIMA, SATOSHI TAMAKI, SHINJI ITOYAMA
Journal: Clinical Nuclear Medicine (1991)

A case of neoplastic angioendotheliosis of the lung is reported. A 56-year-old man presented with a 2-month history of fever, increased serum lactic dehydrogenase, and arterial hypoxemia. Chest radiography revealed diffuse reticulonodular opacity, whereas CT scanning showed diffuse small nodular areas of increased attenuation with indistinct borders. Diffuse pulmonary uptake of Ga-67 was noted in scintigraphy. Combination chemotherapy designed for lymphoma induced a remission of the disease.
115. In Vivo Expression of Human Cob(I)alamin Adenosyltransferase Using rAAV Serotypes 1,2 and 8, an Approach to Gene Therapy for Methylmalonic Aciduria (MMA)
Authors: Kirsten E. Erger, Thomas J. Conlon, Travis L. Cossette, Thomas A. Bobik, Terence R. Flotte
Journal: Molecular Therapy (2005)
Drug-induced hemolysis: Cefotetan-dependent hemolytic anemia mimicking an acute intravascular immune transfusion reaction
Authors: David Stroncek, Jo L. Procter, Judy Johnson
Journal: American Journal of Hematology (2000)

Numerous cases of drug-induced hemolytic anemia have been described in patients treated with penicillin or cephalosporin. Second and third generation cephalosporins are more commonly implicated in hemolytic reactions than first generation cephalosporins. We report a case of severe cefotetan-induced hemolytic anemia in a previously healthy 46-year-old woman undergoing an elective hysterectomy. The patient received 2 g of intravenous cefotetan intraoperatively and subsequently at 12 and 24 h post-operatively. She complained of diarrhea and fever on the third post-operative day and was seen in her gynecologist's office on the fifth post-operative day (hemoglobin = 10.5 g/dL). On the seventh post-operative day, she complained of fever and soreness around the suprapubic catheter site and was given a prescription for 500 mg oral cephalexin four times a day. The next day she was seen in the gynecologist's office and reported feeling better. Ten days after the operation her fatigue worsened and her hemoglobin was 4.8 g/dL. She was transfused with 3 units of packed red blood cells (PRBC) and was given 1 g of cefotetan intravenously. During the transfusion of the second unit of PRBC nursing staff observed gross hemoglobinuria and she subsequently developed acute renal failure. Laboratory chemistry parameters were consistent with severe acute hemolysis. The patient's direct antiglobulin test was reactive and her serum reacted with cefotetan-coated red blood cells (RBCs) and serum plus soluble cefotetan reacted with untreated RBCs. The titration endpoint of the serum against cefotetan-coated RBCs was 40,960, while the serum plus soluble cefotetan against uncoated RBCs was 2,560. This case of severe cefotetan-induced hemolysis was complicated by an acute hemolytic event that occurred during the transfusion of PRBC. Clinical and transfusion service staff must consider drug-induced hemolysis in the differential diagnosis of acute anemia. Am. J. Hematol. 64:67–70, 2000. Published 2000 Wiley-Liss, Inc.
GLOBAL LEFT ATRIAL DEFORMATION IS ASSOCIATED WITH SILENT BRAIN INFARCTS: THE CARDIOVASCULAR ABNORMALITIES AND BRAIN LESIONS (CABL) STUDY
Authors: Aylin Tugcu, Cesare Russo, Zhezhen Jin, Mitsuhiro Yoshita, Shunichi Homma, Mitchell Elkind, Tatjana Rundek, Charles DeCarli, Clinton Wright, Ralph Sacco, Marco Di Tullio
Journal: Journal of the American College of Cardiology (2013)
Impacts of Gene Essentiality, Expression Pattern, and Gene Compactness on the Evolutionary Rate of Mammalian Proteins
Authors: Ben-Yang Liao, Nicole M. Scott, Jianzhi Zhang
Journal: Molecular Biology and Evolution (2006)

Understanding the determinants of the rate of protein sequence evolution is of fundamental importance in evolutionary biology. Many recent studies have focused on the yeast because of the availability of many genome-wide expressional and functional data. Yeast studies revealed a predominant role of gene expression level and a minor role of gene essentiality in determining the rate of protein sequence evolution. Whether these rules apply to complex organisms such as mammals is unclear. Here we assemble a list of 1,138 essential and 2,341 nonessential mouse genes based on targeted gene deletion experiments and report a significant impact of gene essentiality on the rate of mammalian protein evolution. Gene expression level has virtually no effect, although tissue specificity in expression pattern has a strong influence. Unexpectedly, gene compactness, measured by average intron size and untranslated region length, has the greatest influence. Hence, the relative importance of the various factors in determining the rate of mammalian protein evolution is gene compactness > gene essentiality ≈ tissue specificity > expression level. Our results suggest a considerable variation in rate determinants between unicellular organisms such as the yeast and multicellular organisms such as mammals.
Rhinovirus Infections and Allergic Sensitization Among Costa Rican Children Treated for Acute Wheezing
Authors: P.W. Heymann, M. Soto-Quiros, L. Avila, J. Hunt, T. Platts-Mills, H. Carper, D. Murphy, S. Odio, A. O'Rourke, M. Davis
Journal: Journal of Allergy and Clinical Immunology (2010)
Book Review Female Urology, Urogynecology, and Voiding Dysfunction Edited by Sandip P. Vasavada, Rodney A. Appell, Peter K. Sand, and Shlomo Raz. 950 pp., illustrated. New York, Marcel Dekker, 2005. $149.95. 0-8247-5426-3
Authors: Raymond T. Foster
Journal: New England Journal of Medicine (2005)
Present Status of Endoscopic Laser Techniques in Urology
Authors: H. Bülow
Journal: Endoscopy (1979)

Following a brief description of the physical and biomedical characteristics of laser light, a report is given on the development and present status of laser endoscopy in urology. Presently there appear to be two principal indications: i. e. certain bladder tumors and urethral strictures. Neodymium: YAG and argon ion lasers are used for both disorders. The special laser features of these instruments are described.