Dermatologic Disease during Interferon-α Therapy for Chronic Viral Hepatitis
Authors: Georgios N. Dalekos
Journal: Annals of Internal Medicine (1998)

Letters1 March 1998Dermatologic Disease during Interferon-α Therapy for Chronic Viral HepatitisGeorgios N. Dalekos, MD, John Hatzis, MD, and Epameinondas V. Tsianos, MDGeorgios N. Dalekos, MDUniversity of Ioannina Medical School; Ioannina, GreeceSearch for more papers by this author, John Hatzis, MDUniversity of Ioannina Medical School; Ioannina, GreeceSearch for more papers by this author, and Epameinondas V. Tsianos, MDUniversity of Ioannina Medical School; Ioannina, GreeceSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-5-199803010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Immune-mediated dermatologic disease, particularly lichen planus, may accompany chronic viral hepatitis [1]. Interferon-α therapy may also account for immune-mediated phenomena [2]. Psoriasis and lichen planus have been seen during interferon-α treatment of cancer [2]. Despite case reports of lichen planus during interferon-α therapy, a large Japanese study [3] found no immune-mediated dermatologic disease, and a retrospective Italian study [4] found a prevalence of 0.12%.We prospectively evaluated the development of dermatologic disease in 120 consecutive patients with chronic viral hepatitis (67 with hepatitis B, 45 with hepatitis C, 6 with hepatitis B and C, and 2 with ...References1. Pawlotsky JM, Yahia MB, Andre C, Voisin MC, Intrator L, Roudot-Thoraval F, et al. Immunological disorders in C virus chronic active hepatitis: a prospective case–control study. Hepatology. 1994; 19:841-8. Google Scholar2. Conlon KC, Urba WJ, Smith JW, Steis RG, Longo DL, Clark JW. Exacerbation of symptoms of autoimmune disease in patients receiving α-interferon therapy. Cancer. 1990; 65:2237-42. Google Scholar3. Okanoue T, Sakamoto S, Itoh Y, Minami Y, Yasui K, Sakamoto M, et al. Side effects of high-dose interferon therapy for chronic hepatitis C. J Hepatol. 1996; 25:283-91. Google Scholar4. Fattovich G, Giustina G, Favarato S, Ruol A. A survey of adverse events in 11241 patients with chronic viral hepatitis treated with α interferon. The Italian Association for the Study of the Liver. J Hepatol. 1996; 24:38-47. Google Scholar5. Dalekos GN, Manoussakis MN, Zervou E, Tsianos EV, Moutsopoulos HM. Immunologic and viral markers in the circulation of anti-HIV negative heroin addicts. Eur J Clin Invest. 1993; 23:219-25. Google Scholar Author, Article, and Disclosure InformationAuthors: Georgios N. Dalekos, MD; John Hatzis, MD; Epameinondas V. Tsianos, MDAffiliations: University of Ioannina Medical School; Ioannina, Greece PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInterferon alfaCYTOKINES AND CYTOKINE MODULATORSANTIVIRAL DRUGS, INCLUDING IMMUNOGLOBULINS AND INTERFERONSEffets cutanéo-muqueux indésirables des cytokines et des nouvelles molécules anticancéreusesPegylated Interferons: Clinical Applications in the Management of Hepatitis C InfectionInterferon-α therapy in HBeAg-negative chronic hepatitis B: a long-term prospective study from north-western GreeceAlterations of leptin during IFN-α therapy in patients with chronic viral hepatitisTratamiento dermatológico en pacientes con hepatitis CInterferon alfaEffets cutanés indésirables des chimiothérapies antitumorales et des cytokinesSide Effects of Interferon-α TherapyComplicated lichenoid drug eruptionSide effects of medical therapy for chronic hepatitis CEfectos cutáneos adversos de la quimioterapia antineoplásica y de las citocinasDiffuse inflammatory lesions in patients treated with interferon alfa and ribavirin for hepatitis C: a series of 20 patientsAutoantibodies and defined target autoantigens in autoimmune hepatitis: an overviewThe cutaneous manifestations of viral hepatitisValue of anti-HBc screening of blood donorsfor prevention of HBV infection: results of a 3-year prospective study in Northwestern GreeceInflammatory demyelinating polyneuropathy: A complication of immunotherapy in malignant melanomaHepatitis C virus and lichen planus: A case-control study of 340 patientsEpitope mapping of cytochrome P4502D6 autoantigen in patients with chronic hepatitis C during α-interferon treatmentDrugs acting on the immune systemImmune-mediated dermatological disorders with interferon-?? 1 March 1998Volume 128, Issue 5Page: 409-410KeywordsAntinuclear antibodiesCancer treatmentChronic hepatitisHepatitisHepatitis BHepatitis CHepatitis DLesionsRetrospective studiesViral diseases ePublished: 15 August 2000 Issue Published: 1 March 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...