tbuckley/cabot-search huggingface dataset:
885-6 Prognostic implications of admission hyperglycemia in elderly patients with acute myocardial infarction
Authors: Mikhail Kosiborod, Saif S Rathore, Yongfei Wang, Silvio E Inzucchi, Frederick A Masoudi, Edward P Havranek, JoAnne M Foody, Harlan M Krumholz
Journal: Journal of the American College of Cardiology (2004)
Lichenoid tissue reaction in porphyria cutanea tarda
Authors: None Creamer, None Mcgregor, None Mcfadden, None Hawk
Journal: British Journal of Dermatology (1999)

We report a patient presenting with lichenoid plaques on exposed skin who had the metabolic features of porphyria cutanea tarda (PCT). Histology of lesional skin demonstrated a lichenoid inflammatory cell infiltrate in the upper dermis, while direct immunofluorescence revealed immunoreactive colloid bodies. Monochromator irradiation testing demonstrated photosensitivity in the visible spectrum consistent with porphyria. Solar-simulated irradiation induced a papular reaction with lichenoid histological changes. We propose that this atypical presentation of PCT may reflect a lichenoid tissue response to a porphyrin-mediated photochemical reaction.
Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse
Authors: Heather M Kulaga, Carmen C Leitch, Erica R Eichers, Jose L Badano, Alysa Lesemann, Bethan E Hoskins, James R Lupski, Philip L Beales, Randall R Reed, Nicholas Katsanis
Journal: Nature Genetics (2004)
Anaphylactoid Purpura, Cold Exposure, and Cryofibrinogenemia
Authors: William R. Griswold, Gilbert Simon, Rawle M. Mcintosh
Journal: Annals of Internal Medicine (1973)

Letters1 April 1973Anaphylactoid Purpura, Cold Exposure, and CryofibrinogenemiaWILLIAM R. GRISWOLD, M.D., GILBERT SIMON, M.D., RAWLE M. MCINTOSH, M.D.WILLIAM R. GRISWOLD, M.D.Search for more papers by this author, GILBERT SIMON, M.D.Search for more papers by this author, RAWLE M. MCINTOSH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-4-611_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Anaphylactoid pupura (Henoch-Schönlein purpura) is a syndrome of nonthrombocytopenic purpura, arthralgia, abdominal pain, gastrointestinal bleeding, and nephropathy. The cause is unknown, but immunologic and hematologic mechanisms seem to be involved. Recently we have observed a boy with this syndrome whose symptoms exacerbated after exposure to cold. Examination of his plasma showed cryofibrinogenemia.This 4-year-old boy developed a mild urticarial and purpuric rash after cold exposure. One week later, while playing in the snow for an entire afternoon, he developed ecchymotic lesions on the legs and buttocks, pedal edema, and severe arthralgias of the knees and ankles. He...References1. MCINTOSHKAUFMANKULVINSKAS RDC: Cryoglobulins. I. The nature, incidence and clinical significance of cryoproteins in glomerulonephritis. J Lab Clin Med 75:566-577, 1970 MedlineGoogle Scholar2. MCKEEKALBFLEISCHBIRD PJR: Incidence and significance of cryofibrinogenemia. J Lab Clin Med 61:203-210, 1963 Google Scholar3. RITZMANNLEVIN SW: Cryopathies: a review. Arch Intern Med 107:186-204, 1961 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCryofibrinogen-Associated GlomerulonephritisClinical Significance of Cryofibrinogenemia: Possible Pathophysiological Link with Raynaud’s PhenomenonA 5-year prospective follow-up study in essential cryofibrinogenemia patientsLes cryofibrinogénémiesCryofibrinogenemia: New Insights into Clinical and Pathogenic FeaturesCryofibrinogenaemia: a study of 49 patientsSecondary Cryofibrinogenaemia with Leukocytoclastic Vasculitis.Essential cryofibrinogenaemia, leukocytoclastic vasculitis and chronic purpuraThe rheumatic poison: a survey of some published investigations of the immunopathogenesis of Henoch-Sch�nlein purpuraTransient nephrotic syndrome after anaesthesia resulting from a familial cryofibrinogen precipitating at 35 degrees C.Purpura Associated with Exposure to SunlightCutaneous lesions in cryofibrinogenemiaHenoch-Schönlein Nephritis: Prognostic Features and the Challenge of Therapy 1 April 1973Volume 78, Issue 4Page: 611-611KeywordsAbdominal painAnklesArthralgiaBlood plasmaEdemaHemorrhageKneesLesionsRashes Issue Published: 1 April 1973 PDF downloadLoading ...
Dietary Intake of Methionine, Cysteine, and Protein and Urinary Arsenic Excretion in Bangladesh
Authors: Julia E. Heck, Jeri W. Nieves, Yu Chen, Faruque Parvez, Paul W. Brandt-Rauf, Joseph H. Graziano, Vesna Slavkovich, Geoffrey R. Howe, Habibul Ahsan
Journal: Environmental Health Perspectives (2008)

In Bangladesh, millions of people are exposed to arsenic in drinking water; arsenic is associated with increased risk of cancer. Once ingested, arsenic is metabolized via methylation and excreted in urine. Knowledge about nutritional factors affecting individual variation in methylation is limited.The purpose of this study was to examine associations between intakes of protein, methionine, and cysteine total urinary arsenic in a large population-based sample.The study subjects were 10,402 disease-free residents of Araihazar, Bangladesh, who participated in the Health Effects of Arsenic Longitudinal Study (HEALS). Food intakes were assessed using a validated food frequency questionnaire developed for the study population. Nutrient composition was determined by using the U.S. Department of Agriculture National Nutrient Database for Standard Reference. Generalized estimating equations were used to examine association between total urinary arsenic across quintiles of nutrient intakes while controlling for arsenic exposure from drinking water and other predictors of urinary arsenic.Greater intakes of protein, methionine, and cysteine were associated with 10-15% greater total urinary arsenic excretion, after controlling for total energy intake, body weight, sex, age, tobacco use, and intake of some other nutrients.Given previously reported risks between lower rates of arsenic excretion and increased rates of cancer, these findings support the role of nutrition in preventing arsenic-related disease.
Phase II Study of Gemcitabine, Cisplatin, and Infusional Fluorouracil in Advanced Pancreatic Cancer
Authors: B.F. El-Rayes, M.M. Zalupski, A.F. Shields, U. Vaishampayan, L.K. Heilbrun, V. Jain, V. Adsay, J. Day, P.A. Philip
Journal: Journal of Clinical Oncology (2003)

Purpose: This phase II study was undertaken to determine the efficacy of adding infusional fluorouracil (FU) to the chemotherapy doublet of gemcitabine and cisplatin in patients with advanced pancreatic cancer. Patients and Methods: The eligibility criteria included histologically or cytologically confirmed adenocarcinoma of the pancreas that was either unresectable or metastatic. No prior gemcitabine therapy was allowed. Patients received a combination of gemcitabine 1,000 mg/m 2 intravenously (IV) on days 1, 8, and 15; cisplatin 50 mg/m 2 IV on days 1 and 15; and FU 175 mg/m 2 /d from days 1 to 15 by continuous IV infusion. Cycles were repeated every 28 days. Objective tumor response and toxicity were evaluated according to the World Health Organization criteria. Results: A total of 47 patients (median age, 57 years; males, 59%) were enrolled. Sixteen patients had locally advanced (LA) disease, and 31 patients had metastatic disease. A total of 183 cycles of chemotherapy were administered. In patients with metastatic disease (n = 31), the probability of survival at 6 and 12 months was 66% and 34%, respectively. Objective partial response or stable disease was observed in 26% (90% confidence interval [CI], 0.14 to 0.41) and 61% (90% CI, 0.45 to 0.74) of patients, respectively. In patients with LA disease (n = 16), there were three partial responses (19%; 90 CI, 0.07 to 0.39). One patient in this group was successfully resected after FU-based radiotherapy. The most common grade 3 to 4 toxicities were neutropenia (60%), thrombocytopenia (42%), and anemia (26%). Thirteen patients were hospitalized for treatment-related complications. Conclusion: The combination of gemcitabine, cisplatin, and infusional FU has significant activity in patients with advanced pancreatic cancer.
The Confusions and Consolations of Uncertainty
Authors: F. J. Ingelfinger
Journal: New England Journal of Medicine (1975)

Does coffee drinking predispose to coronary-artery disease?May oral antidiabetic agents curtail rather than prolong life?Do the common tranquilizers meprobamate and chlordiazepoxide, if taken by a pregnant woman, harm the fetus?Does reserpine make a woman more susceptible to cancer of the breast? In the last 20 years, increasing and improved use of epidemiologic technics has contributed immensely to making treatment more efficacious and safe. Yet Feinstein's comments in the preceding editorial and the four questions listed above indicate some of the controversial aspects that remain concerning the usefulness of pharmaceutical agents and their safety.The first two questions . . .
Diabetes and Coronary Risk Equivalency
Authors: Scott M. Grundy
Journal: Diabetes Care (2006)

The National Cholesterol Education Program Adult Treatment Panel III (ATP III) listed diabetes as a coronary heart disease (CHD) risk equivalent for setting therapeutic goals for LDL cholesterol (1). A goal for LDL cholesterol of  20%. For the majority of patients with diabetes, this LDL cholesterol goal would evoke the use of cholesterol-lowering drugs, particularly statins. Some investigators have questioned whether most or all patients with diabetes have a CHD risk equivalent and thus require cholesterol-lowering drugs (2). One approach to this issue is to examine epidemiological data relating to absolute risk for developing CHD in various populations of persons with diabetes.

In the present issue of Diabetes Care , Howard et al. (3) reported the incidence of CHD in the Strong Heart Study, a cohort study of cardiovascular disease (CVD) in 13 American-Indian tribes/communities conducted in three study centers in southwestern Oklahoma, central Arizona, and North and South Dakota. The population of the Strong Heart Study has a high prevalence of type 2 diabetes and CVD associated with diabetes. The findings of this study showed wide variation in rates of CHD in patients with diabetes, depending in part on coexisting risk factors. Most individuals had 10-year risk >20%, the threshold for ATP III’s CHD risk equivalency, but only those with multiple risk factors had rates of CHD events equivalent to patients with established CHD. The authors conclude that it may be prudent to consider therapeutic goals for risk factors based on the entire risk factor profile, rather than just the presence of diabetes.

Other studies likewise have found …
Cardiometabolic Risk in a Rural Ugandan Population
Authors: Georgina A.V. Murphy, Gershim Asiki, Elizabeth H. Young, Janet Seeley, Rebecca N. Nsubuga, Manjinder S. Sandhu, Anatoli Kamali
Journal: Diabetes Care (2013)

Although many studies have examined metabolic syndrome (MetS) and the Framingham Risk Score (FRS), few studies have been carried out in African populations. This limited information on MetS and FRS leaves us with an incomplete understanding of the prevalence and distribution of risk of cardiometabolic disease in sub-Saharan Africa (SSA). It also prevents us from critically evaluating how each of the varying definitions of MetS compares in African populations. A clearer understanding of MetS and FRS in African populations may provide the basis for better identifying the impact of these definitions and tools on disease risk and, furthermore, help to evaluate the usefulness of such tools for research and for informing public health care and prevention policy in SSA.
COMPARISON OF ACUTE ELASTIC RECOIL BETWEEN THE SAPIEN-XT AND SAPIEN VALVES IN TRANSFEMORAL-TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Aatish Garg, Akhil Parashar, Shikhar Agarwal, Olcay Aksoy, Muhammad Hammadah, Kanhaiya Poddar, Rishi Puri, Lars Svensson, Amar Krishnaswamy, E. Murat Tuzcu, Samir Kapadia
Journal: Journal of the American College of Cardiology (2014)
Democratisation of scientific advice
Authors: John R Kemm
Journal: BMJ (2005)

a banner headline on the front page of a popular tabloid newspaper read: "Cancer danger of folic acid" on the basis of a paper by Charles et al on taking folate in pregnancy and risk of maternal breast cancer. 1 2 Although coverage in the broadsheets was more balanced, the overall message would inevitably cause concern to women taking folate to reduce the risk of fetal neural tube defect in a desired pregnancy.Despite the likelihood that the most likely explanation for the reported association is chance, as reported in the commentary to the paper, 2 numerous susceptible women will probably not take folate, and some of these may conceive fetuses with neural tube defects.In addition, what company or government will take responsibility for fortification of wheat and corn flour with folate, now that this question has been raised?The authors themselves point out that the numbers are small and the confidence intervals large.The risk was also associated with a much larger dose of folate than is routinely used to reduce the risk of neural tube defects.Those who write such papers and those who publish them cannot disclaim ethical responsibility for how the data are interpreted and must consider more carefully their ethical responsibilities in such situations.
Biodegradation and antitumour effect of adriamycin-containing poly(l-lactic acid) microspheres
Authors: Osamu Ike, Yasuhiko Shimizu, Yoshito Ikada, Satoshi Watanabe, Tohru Natsume, Ryoichi Wada, Suong-Hyu Hyon, Shigeki Hitomi
Journal: Biomaterials (1991)
IL-13 desensitizes β2-adrenergic receptors in human airway epithelial cells through a 15-lipoxygenase/G protein receptor kinase 2 mechanism
Authors: Giusy D. Albano, Jinming Zhao, Emily B. Etling, Seo Young Park, Haizhen Hu, John B. Trudeau, Mirella Profita, Sally E. Wenzel
Journal: Journal of Allergy and Clinical Immunology (2015)
Peripheral-blood mononuclear cell responses to recombinant hepatitis C virus antigens in patients with chronic hepatitis C
Authors: Haim Schupper, Paul Hayashi, James Scheffel, Sherri Acettuno, Teresa Paglieroni, Paul V. Holland, Jerome B. Zeldis
Journal: Hepatology (1993)

Peripheral blood mononuclear cell proliferative responses in vitro to recombinant yeast or Escherichia coli hepatitis C virus fusion proteins were evaluated in 20 patients with chronic hepatitis C who were reactive for antibody to hepatitis C virus (on enzyme immunoassay, version 2.0, and a four-antigen recombinant immunoblot assay). Twenty age-matched, healthy individuals negative for antibody to hepatitis C virus were used as a control group. Peripheral-blood mononuclear cells from all chronic hepatitis C patients with antibodies to hepatitis C virus antigens c22 and c100-3 proliferated in vitro in response to the corresponding recombinant hepatitis C virus fusion protein. Peripheral-blood mononuclear cells from 75% of patients infected with hepatitis C virus proliferated in response to cytidine monophosphate-keto-3-deoxyoctulosonic acid-core recombinant antigen but there was no proliferative response to cytidine monophosphate-keto-3-deoxyoctulosonic acid-EF (derived from the NS5 region). All hepatitis C virus-infected patients had 33c antibody, but peripheral-blood mononuclear cells from only 9 of 14 (64%) proliferated in vitro in response to 33c. Ninety-five percent of all hepatitis C virus-infected patients had peripheral-blood mononuclear cells that proliferated in response to at least one recombinant hepatitis C virus fusion protein. The numbers and percentages of CD3 T cells, CD19 B cells and natural killer cells from patients with chronic hepatitis C virus infection did not differ from those in the healthy control group. However, the number of non-major histocompatibility complex-restricted cytotoxic T cells (CD3-positive, CD56-positive, CD16-positive) was increased in patients with chronic hepatitis C virus infection (p < 0.05).
General Motors Prizes Honor Four Cancer Scientists
Authors: A. Jacobs-Perkins
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article General Motors Prizes Honor Four Cancer Scientists Get access Andree Jacobs-Perkins Andree Jacobs-Perkins Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 13, 4 July 1990, Pages 1094–1096, https://doi.org/10.1093/jnci/82.13.1094 Published: 04 July 1990
Quantitative Methylation-Specific Polymerase Chain Reaction Gene Patterns in Urine Sediment Distinguish Prostate Cancer Patients From Control Subjects
Authors: Mohammad Obaidul Hoque, Ozlem Topaloglu, Shahnaz Begum, Rui Henrique, Eli Rosenbaum, Wim Van Criekinge, William H. Westra, David Sidransky
Journal: Journal of Clinical Oncology (2005)

Purpose Aberrant promoter hypermethylation of several known or putative tumor suppressor genes occurs frequently during the pathogenesis of prostate cancers and is a promising marker for cancer detection. We sought to develop a test for prostate cancer based on a quantitative methylation-specific polymerase chain reaction (QMSP) of multiple genes in urine sediment DNA. Patients and Methods We tested urine sediment DNA for aberrant methylation of nine gene promoters (p16INK4a, p14 ARF , MGMT, GSTP1, RARβ2, CDH1 [E-cadherin], TIMP3, Rassf1A, and APC) from 52 patients with prostate cancer and 21 matched primary tumors by quantitative fluorogenic real-time polymerase chain reaction. We also analyzed urine sediments from 91 age-matched individuals without any history of genitourinary malignancy as controls. Results Promoter hypermethylation of at least one of the genes studied was detected in urine samples from all 52 prostate cancer patients. Urine samples from the 91 controls without evidence of genitourinary cancer revealed no methylation of the p16, ARF, MGMT, and GSTP1 gene promoters, whereas methylation of RARβ2, TIMP3, CDH1, Rassf1A, and APC was detected at low levels. Conclusion Overall, methylation found in urine samples matched the methylation status in the primary tumor. A combination of only four genes (p16, ARF, MGMT, and GSTP1) would theoretically allow us to detect 87% of prostate cancers with 100% specificity. Our data support further development of the noninvasive QMSP assay in urine DNA for early detection and surveillance of prostate cancer.
Autoimmune hemolytic anemia
Authors: Bradley C. Gehrs, Richard C. Friedberg
Journal: American Journal of Hematology (2002)

Abstract Red blood cell (RBC) autoantibodies are a relatively uncommon cause of anemia. However, autoimmune hemolytic anemia (AIHA) must be considered in the differential diagnosis of hemolytic anemias, especially if the patient has a concomitant lymphoproliferative disorder, autoimmune disease, or viral or mycoplasmal infection. Classifications of AIHA include warm AIHA, cold agglutinin syndrome, paroxysmal cold hemoglobinuria, mixed‐type AIHA, and drug‐induced AIHA. Characteristics of the autoantibodies are responsible for the various clinical entities. As a result, diagnosis is based on the clinical presentation and a serologic work‐up. For each classification of AIHA, this review discusses the demographics, etiology, clinical presentation, laboratory evaluation, and treatment options. Am. J. Hematol. 69:258–271, 2002. © 2002 Wiley‐Liss, Inc.
Pemphigus vegetans presenting with deafness, otalgia and facial nerve paralysis
Authors: W. Fujimoto, N. Hirano, M. Miyashita, J. Arata, C. Saito
Journal: British Journal of Dermatology (1991)

Journal Article Pemphigus vegetans presenting with deafness, otalgia and facial nerve paralysis Get access W. Fujimoto, W. Fujimoto Department of Dermatology and * Otorhinolaryngology. Okayama University Medical School, Shikata‐cho 2‐5‐1, Okayama 700. Japan Search for other works by this author on: Oxford Academic Google Scholar N. Hirano, N. Hirano Department of Dermatology and * Otorhinolaryngology. Okayama University Medical School, Shikata‐cho 2‐5‐1, Okayama 700. Japan Search for other works by this author on: Oxford Academic Google Scholar M. Miyashita, M. Miyashita Department of Dermatology and * Otorhinolaryngology. Okayama University Medical School, Shikata‐cho 2‐5‐1, Okayama 700. Japan Search for other works by this author on: Oxford Academic Google Scholar J. Arata, J. Arata Department of Dermatology and * Otorhinolaryngology. Okayama University Medical School, Shikata‐cho 2‐5‐1, Okayama 700. Japan Search for other works by this author on: Oxford Academic Google Scholar C. Saito C. Saito Department of Dermatology and * Otorhinolaryngology. Okayama University Medical School, Shikata‐cho 2‐5‐1, Okayama 700. Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 124, Issue 6, 1 June 1991, Pages 609–610, https://doi.org/10.1111/j.1365-2133.1991.tb04961.x Published: 01 June 1991
Prolonged activity of factor IX as a monomeric Fc fusion protein
Authors: Robert T. Peters, Susan C. Low, George D. Kamphaus, Jennifer A. Dumont, John V. Amari, Qi Lu, Greg Zarbis-Papastoitsis, Thomas J. Reidy, Elizabeth P. Merricks, Timothy C. Nichols, Alan J. Bitonti
Journal: Blood (2010)
Studies of the Renal Circulation
Authors: JOSEPH R. KAHN, LEONARD T. SKEGGS, NORMAN P. SHUMWAY
Journal: Circulation (1950)

This work represents an attempt to confirm reported observations of a juxtamedullary by-pass in the kidneys of animals subjected to various physiologic procedures and to shock. Rabbits injected with epinephrine, pitressin, renin and hypertensin, made hypotensive by bleeding and inhalation of amyl nitrite, and after stimulation of one sciatic nerve, were injected with india ink. The kidneys were removed and studied for the paths of blood flow. No evidence of a by-pass mechanism through the juxtamedullary glomeruli was found.
Factors that influence patients in Sri Lanka in their choice between Ayurvedic and Western medicine
Authors: D. Samarasinghe
Journal: BMJ (1985)

attendance-the existence of long established diabetic clinics in two big hospitals within 4 kilometres, relatively well informed town folk, and the belief that Ayurveda had very little to offer in the treatment of diabetes.Hence, the factors that influence patients in their choice between Ayurvedic and Western type medicine are rather complex and need a deeper understanding of the way of life in different parts of Sri Lanka and the types of disease prevalent.
Secretory phospholipase A2 and neonatal respiratory distress: pilot study on broncho-alveolar lavage
Authors: Daniele De Luca, Silvia Baroni, Giovanni Vento, Marco Piastra, Domenico Pietrini, Federica Romitelli, Ettore Capoluongo, Costantino Romagnoli, Giorgio Conti, Enrico Zecca
Journal: Intensive Care Medicine (2008)
THE EFFECT OF TESTICLE EXTRACT ON RED BLOOD CELLS IN VITRO
Authors: Giovanni Favilli
Journal: The Journal of Experimental Medicine (1931)

Testicle extract possesses a notable power to increase red cell fragility. Testicle extracts of the rat, rabbit and guinea pig all exhibit this property, which is most pronounced with the extract from the rat and least so with that from the guinea pig. Splenic extract does not possess the property, or possesses it only to a very slight degree. These results support the hypothesis that the factor in testicle extract which enhances infections (the Reynals factor) does so by altering the permeability of the host tissue.
Pivotal role of M-DC8+ monocytes from viremic HIV-infected patients in TNFα overproduction in response to microbial products
Authors: Charles-Antoine Dutertre, Sonia Amraoui, Annalisa DeRosa, Jean-Pierre Jourdain, Lene Vimeux, Matthieu Goguet, Séverine Degrelle, Vincent Feuillet, Anne-Sophie Liovat, Michaela Müller-Trutwin, Nipa Decroix, Christiane Deveau, Laurence Meyer, Cécile Goujard, Pierre Loulergue, Odile Launay, Yolande Richard, Anne Hosmalin
Journal: Blood (2012)