tbuckley/cabot-search huggingface dataset:
Chronic Interstitial Nephritis: Analgesic "Abuse," Hyperuricemia
Authors: ELLEN SCHEINER
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 October 1975Chronic Interstitial Nephritis: Analgesic "Abuse," HyperuricemiaELLEN SCHEINER, M.D.ELLEN SCHEINER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-4-576 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Murray and Goldberg reviewed in their recent paper "Chronic Interstitial Nephritis: Etiologic Factors" (1), 101 cases of interstitial nephritis and concluded that in 20 "analgesic abuse nephropathy" was present. Many of these patients (85%) were women who suffered from headache (80%). A supposedly significant number (10% or 2 patients!) had required psychiatric help. The pedigree of a family with frequent headaches is displayed. The proposita is a 48-year-old woman with more than 30 years of analgesic "abuse" for recurrent headaches. The point of this aspect of the paper appears to be that analgesic abuse is familial. It...Reference1. MURRAYGOLDBERG TM: Chronic interstitial nephritis: etiologic factors. Ann Intern Med 82:453-459, 1975 LinkGoogle Scholar1. MURRAYGOLDBERG TM: Chronic interstitial nephritis: etiologic factors. Ann Intern Med 82:453-459, 1975 LinkGoogle Scholar2. SMITH L: Disorders of purine metabolism: gout, in Textbook of Medicine, edited by BEESON PB, MCDERMOTT W. Philadelphia, W. B. Saunders and Co., 1971, p. 1691 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ELLEN SCHEINER, M.D.Affiliations: Memorial Sloan-Kettering Cancer Center New York, New York 10021 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1975Volume 83, Issue 4Page: 576-577KeywordsAnalgesicsHeadachesNephritis ePublished: 1 December 2008 Issue Published: 1 October 1975 PDF downloadLoading ...
Future developments in sublingual immunotherapy
Authors: A. Didier
Journal: Allergy (2006)

The increasing prevalence of allergic rhinitis and its progression to asthma has severe implications for patients and health care systems in many countries. An ideal therapy is one that is effective not only against symptoms but also towards the natural progression of the allergic disease. Immunotherapy is recognized to achieve both these aims. Administration of allergens by the sublingual route, a modality with a very low rate of systemic reactions, is widely considered a treatment of choice. However, if it is to be universally accepted, more developments are required. Although, it is effective against grass and other seasonal pollens, further controlled trials are needed to confirm its efficacy against perennial allergens. Additional studies, particularly in paediatric populations, are needed to confirm its long-term effects on disease progression. New vaccine developments, which take into account the increasing understanding of the underlying immune mechanisms and that exploit molecular engineering techniques will create allergens that are effective, stable, risk free and easy to administer.
Increased Lipoprotein(a) Is an Important Risk Factor for Venous Thromboembolism in Childhood
Authors: Ulrike Nowak-Göttl, Ralf Junker, Marion Hartmeier, Hans-Georg Koch, Nicole Münchow, Gerd Assmann, Arnold von Eckardstein
Journal: Circulation (1999)

Background —Serum levels of lipoprotein(a) [Lp(a)] are determined largely by genetic variation in the gene encoding for apolipoprotein(a) [apo(a)], the specific protein component of Lp(a) that is very homologous to plasminogen. High plasma levels of Lp(a) increase the risk for premature atherosclerotic vessel diseases. We investigated the little-characterized role of Lp(a) as a risk factor for venous thromboembolic diseases, alone and in conjunction with established thrombophilic risk factors of proteins regulating blood coagulation and fibrinolysis. Methods and Results —Serum levels of Lp(a) and lipids, protein C, protein S, and antithrombin, as well as the size of apo(a) isoforms and the presence of the factor V:Q 506 mutation, were determined in 186 consecutively admitted children from neonates to 18 years old with a history of venous thrombosis and in 186 age- and disease-matched control subjects. Children with a history of venous thrombosis had a significantly higher median Lp(a) level (19 versus 4.4 mg/dL) than control subjects. The risk for thromboembolic events in children with Lp(a) levels in the upper quartile, ie, &gt;30 mg/dL, was 7.2 (95% CI, 3.7 to 14.5). The size of apo(a) isoforms was inversely related to Lp(a) levels and to the risk for thromboembolic events. Compared with the highest quartile of the apo(a) size distribution, the lowest quartile was associated with a risk of 8.2. In addition, multivariate statistical analysis gives evidence that the factor V:Q 506 mutation (OR/CI, 2.8/1.6 to 4.9), protein C (OR/CI, 6.5/2.1 to 19), and antithrombin deficiency (OR/CI, 10.4/1.2 to 90) were independent risk factors of childhood venous thrombosis. Coincidence of elevated Lp(a) with factor V:Q 506 mutation or deficiencies of protein C or antithrombin further increased the risk for thromboembolic events to 8.4. Conclusions —Lp(a) &gt;30 mg/dL is a risk factor for venous thromboembolism in childhood. Lp(a) measurements should be included in the screening of causal factors in children with venous thromboembolic events.
Schistosome Infections in Humans: Perspectives and Recent Findings
Authors: THEODORE E. NASH
Journal: Annals of Internal Medicine (1982)

Approximately 200 million persons are infected with schistosomes. Of those infected, a small proportion develop serious chronic disease, usually after years of intensive exposure and infection. Schistosoma mansoni and Schistosoma japonicum reside in the mesenteric veins and produce liver fibrosis, which results in portal hypertension and bleeding esophageal varices but little hepatocellular dysfunction. Schistosoma haematobium resides primarily in the pelvic veins and produces mass lesions in the bladder and ureters, which lead to hydroureter and hydronephrosis. The intensity of infection is a major factor determining development of disease, but differences in worm strain and host response may also be important. In acute schistosomiasis there is an intense response to the parasite, which is suppressed as the infection becomes chronic. The marked inflammatory response seen in early and acute schistosomiasis becomes less intense and fibrotic lesions predominate. The recent advent of safe, effective, and easily administered chemotherapeutic reagents will aid in the control of schistosomiasis.
770 Impact of hepatitis C viral (HCV) infection in primary cadaveric liver allograft v/s primarily living liver allograft in 100 consecutive liver transplant patients?
Authors: A BOZORGZADEH, A JAIN, J DALLER, C RYAN, U SUNDRUM, K LANSING, D KAUFMAN, D ORNT, M ZAND, R BETTS
Journal: Hepatology (2003)
Rheumatoid Arthritis, 1970-1972
Authors: JOHN S. JOHNSON
Journal: Annals of Internal Medicine (1973)

Major developments and trends in the study and management of rheumatoid arthritis from 1970 through 1972 are reviewed. Its prevalence and genetics, pathologic features and metabolic abnormalities, manifestations and complications, etiology, pathogenesis, and treatment are discussed. Infection, an important complication of rheumatoid arthritis, is also pertinent to its etiology. Immune mechanisms are increasingly implicated in the pathogenesis of the disease. There is little change in major principles of management, although methods of assessing disease activity have been improved. Emphasis on the use of immunosuppressive drugs is increasing.
What have we learnt from the rosiglitazone saga?
Authors: V. M. Montori, N. D. Shah
Journal: BMJ (2011)

<h3>PURPOSE</h3> To study the utility of high-dose contrast enhancement in the detection of recurrent herniated disk fragments. <h3>METHODS</h3> Recurrent herniated disks were modeled in nine dogs by placing a fragment of normal autologous disk tissue in the epidural space at laminectomy. MR was performed at 30, 60, and 90 days with 0.3 mmol/kg of gadoteridol and repeated 24 hours later with 0.1 mmol/kg of gadopentetate dimeglumine. Contrast enhancement in the disk and scar tissue was measured and conspicuousness of the disk fragments assessed. <h3>RESULTS</h3> In 70% of the animals, disk fragments were more conspicuous with the larger dose of contrast medium than with the smaller dose. In 30% of animals the conspicuousness was approximately equal. Contrast between disk fragment and scar decreased with time elapsed since surgery, with time elapsed since contrast-medium injection, and with decreasing dose of contrast medium. <h3>CONCLUSION</h3> In the experimental model, increased conspicuousness of disk fragments was achieved with the larger dose of contrast medium. A clinical study is needed to confirm that a contrast-medium dose of 0.3 mmol/kg improves detection of recurrent herniated disks over a dose of 0.1 mmol/kg.
Homeostatic proliferation is a barrier to transplantation tolerance
Authors: Zihao Wu, Steven J Bensinger, Jidong Zhang, Chuangqi Chen, Xueli Yuan, Xiaolun Huang, James F Markmann, Alireza Kassaee, Bruce R Rosengard, Wayne W Hancock, Mohamed H Sayegh, Laurence A Turka
Journal: Nature Medicine (2003)
The joy of being electronic
Authors: T. Delamothe, R. Smith
Journal: BMJ (1999)

Websites are like gardens. Turn your back on them for a few weeks and they're overrun with weeds in the form of out of date coming events and hypertext links leading nowhere. But, like gardens, websites offer amazing opportunities to experiment Plant something that doesn't take or produce the effect you wanted and you can take it out and try something else. And, like a garden, the internet is very forgiving—no hard copy archive survives to mock your false starts and wrong turns.

The launch of the BMJ 's full text website in April 1998 coincided with a frenzy of new planting, much of which is coming to fruition this (northern) summer. Most work has been devoted to our collected resources—210 virtual pages each devoted to a single topic These rely on the coding of each journal article with one or more clinical and non-clinical topic codes (for example, the first paper this week has been coded: liver, perinatal, pancreas and biliary tract, and chemical pathology). Not only can website visitors review the archive of all papers published by the BMJ on a particular topic; they can also read relevant papers in the eight online specialist journals published by the BMJ Publishing Group (see box) Each topic page links to relevant Cochrane abstracts, job advertisements on our classified site, and the virtual bookshelf for that specialty within our electronic bookshop—from which books can be bought on line. Over the next few months, we will be adding more resources, beginning with the eBNF (the electronic version of the British National Formulary ). We also plan to appoint green fingered …
Less than half of people undergoing leg amputation get good care, inquiry warns
Authors: S. Mayor
Journal: BMJ (2014)

Less than half of people undergoing a leg amputation in hospitals in England, Wales, and Northern Ireland receive what experts consider good care, warns the latest report from the National Confidential Enquiry into Patient Outcome and Death (NCEPOD).1

Only 229 (44%) of the 519 patients who needed a leg amputation because of vascular disease or diabetes in the six months from 1 October 2012 to 31 March 2013 and whose notes were reviewed by NCEPOD advisers were considered to have received good care, as judged against recommended standards.

The mortality rate among the patients included in the inquiry was 12.4%, higher than the rate among …
Somatostatin Receptor–Positive Granulomatous Inflammation Mimicking as Meningioma on Simultaneous PET/MRI
Authors: Sangeeta Taneja, Amarnath Jena, Sumaid Kaul, Abhishek Jha, Shanti Kumar Sogani
Journal: Clinical Nuclear Medicine (2014)

Positron imaging with radiolabeled synthetic somatostatin receptor analogs such as Ga DOTATATE (Gallium-68-1,4,7,10-tetraazacyclododecane-N,N',N″,N‴-tetra acetic acid-DPhe1,Tyr3-octreotate) is used for diagnosis and target volume delineation of intracranial meningiomas. We report a case of a somatostatin receptor-positive extra-axial necrotizing granulomatous inflammation mimicking as meningioma on simultaneous Ga DOTATATE PET/MRI. This case illustrates a Ga DOTATATE-positive granuloma bearing a striking resemblance to meningioma.
Hue magnitudes and Revelation
Authors: John Kulvicki
Journal: Behavioral and Brain Sciences (2003)

Abstract Revelation, the thesis that the full intrinsic nature of colors is revealed to us by color experiences, is false in Byrne &amp; Hilbert's (B&amp;H's) view, but in an interesting and nonobvious way. I show what would make Revelation true, given B&amp;H's account of colors, and then show why that situation fails to obtain, and why that is interesting.
Anemia in the Elderly
Authors: Preeti N. Malani
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Adverse Neonatal and Cardiac Outcomes Are More Common in Pregnant Women With Cardiac Disease
Authors: Samuel C. Siu, Jack M. Colman, Sheryll Sorensen, Jeffrey F. Smallhorn, Dan Farine, Kofi S. Amankwah, John C. Spears, Mathew Sermer
Journal: Circulation (2002)

Background — Pregnant women with heart disease (HD) are at increased risk for cardiac (CV) complications. However, the frequency of neonatal (NE) complications in pregnant women with HD relative to pregnant women without HD has not been examined. Methods and Results — Pregnant women with HD were prospectively monitored during 302 pregnancies. The frequency of NE and CV complications was compared with those in a control group without HD during 572 pregnancies. The frequency of NE complications was higher in the HD group (18% versus 7%; HD versus controls). The NE complication rate was lowest in pregnancies of women age 20 to 35 years who did not smoke during pregnancy, did not receive anticoagulants, and had no obstetric risk factors: 4% in control patients, 5% in HD patients with no cardiac risk factors for NE complications (left heart obstruction, poor functional class, or cyanosis), and 7% in HD patients with ≥1 such risk factor. In contrast, the event rate in pregnancies of controls age &lt;20 or &gt;35 years who had obstetric risk factors or multiple gestation or who smoked was 11%. In the HD group, women age &lt;20 or &gt;35 years who had obstetric risk factors or multiple gestation, who smoked, or who received anticoagulants experienced an even higher NE complication rate (27% with no cardiac risks for NE events and 33% in the presence of ≥1 cardiac risk factors). The frequency of CV complications was higher in the HD group (17% versus 0%; HD versus controls). Conclusion — Pregnant women with HD are at increased risk for both NE and CV complications. The risk for NE adverse events in pregnant women with HD is highest in those with both obstetric and cardiac risk factors for NE complications.
Thromboatheromatous Aortic Coarctation
Authors: A Sheikhzadeh, H B Gehl
Journal: New England Journal of Medicine (1998)

Figure 1. A 53-year-old man with a family history of premature atherosclerosis, borderline hypercholesterolemia, and a 15-pack-year history of cigarette smoking was seen for intermittent claudication, which had been present for six months. On auscultation, the first heart sound was normal, A2 was prominent, and P2 was normal. There was a 2/6 ejection murmur over the upper part of the chest and a soft, continuous murmur over the intercostal area. There was no evidence of left or right ventricular failure. Blood pressure was 210/85 mm Hg in the right arm, 120/75 mm Hg in the left arm, and . . .
Training for General Practice: Result of Survey into General-practitioner Trainee Scheme
Authors: M. J. Whitfield
Journal: BMJ (1966)

Training for general practice in England and Wales is, generally speaking, inadequate.Some recent suggestions for improving this were made by the B.M.A. (1963), largely concerned with the present trainee year, and by the Council of the College of General Practitioners (1965).The latter proposes a three- year postgraduate training period in suitable hospital appointments and a remodelled trainee period in general practice lasting two years.The number of trainees has fallen from 284 in 1956 to 124 in 1965.Despite increasing interest in this phase of medical education, little is known about the trainee year or the trainees and why they accept a year of relatively low salary when a quicker reward is available as an assistant in general practice or as a registrar in hospital.Generally speaking, the trainee year in England and Wales has a bad name.The reasons for this are many, but basically the cause seems to be the possibility of "exploitation"-the trainee being used as a " free " assistant in the practice.What constitutes exploitation and what constitutes a good training year from the point of view of the trainee are unknown.What is offered by trainers ?What should they be offering ?Basic information is obviously required before any new or modified scheme for training is started.To try to provide this information I devised a lengthy questionary and sent it to all trainees in posts in England and Wales on 1 July 1965.From the 142 trainees 125 completed questionaries were returned.(One was excluded as an atypical case and two others arrived too late for inclusion.)Of the 122 trainees replying, 19 (15.6%) had completed fewer than three months' traineeship, 42 (34.4%)four to six months, 36 (29.5%) seven to nine months, and 25 (20.5%) 10 to 12 months.Information from the questionary is presented here under three headings-Trainee Practitioners, Trainers, and the Trainee Year.
Pneumococcal Septic Shock Is Associated with the Interleukin-10–1082 Gene Promoter Polymorphism
Authors: Bernhard M. Schaaf, Florian Boehmke, Hamed Esnaashari, Ulrike Seitzer, Henning Kothe, Matthias Maass, Peter Zabel, Klaus Dalhoff
Journal: American Journal of Respiratory and Critical Care Medicine (2003)

Polymorphisms in the tumor necrosis factor and interleukin-10 genes, linked to cytokine inducibility, may influence the inflammatory response to infection. We studied the biallelic interleukin-10–1082 promoter, the tumor necrosis factor-α-308 promoter, and the lymphotoxin-α polymorphisms with regard to the development of septic shock in pneumococcal infection. Sixty-nine patients with pneumococcal disease (61 patients with community-acquired pneumonia, 5 patients with meningitis, and 3 patients with pneumonia and meningitis) and 50 age-matched control subjects were included. The polymorphisms were determined by the polymerase chain reaction. In patients with pneumococcal disease, the lipopolysaccharide-stimulated tumor necrosis factor and interleukin-10 release from whole blood were measured by ELISA. Sepsis severity was documented according to standard criteria. No significant genotypic differences were seen between patients and control subjects. Thirteen of 69 patients with pneumococcal disease developed septic shock. Interleukin-10 allele G homozygous patients had the highest risk for septic shock (odds ratio of 6.1; 95% confidence interval, 1.4–27.2; corrected p = 0.024). The stimulated interleukin-10 release was highest in interleukin-10 G homozygous patients (p = 0.04). In conclusion, interleukin-10 polymorphism, associated with high interleukin-10 inducibility, might influence the outcome of pneumococcal infection via induced immunosuppression and impaired bacterial clearance.
A new, simplified and accurate method for determining ejection fraction with two-dimensional echocardiography.
Authors: M A Quinones, A D Waggoner, L A Reduto, J G Nelson, J B Young, W L Winters, L G Ribeiro, R R Miller
Journal: Circulation (1981)

A new method to determine left ventricular (LV) ejection fraction (EF) with wide-angle, two-dimensional echocardiography (2-D echo) has been developed using the parasternal long-axis, apical four-chamber and apical long-axis views. End-diastolic and end-systolic measurements of LV short axes at the base and mid-LV cavity in the parasternal long-axis view and at the upper, middle and lower thirds of the cavity in the apical views are made, from which an averaged minor axis at end-diastolic and at end-systole is calculated. Fractional shortening of the LV long axis (delta L) is estimated from apical contraction. Satisfactory 2-D echoes were obtained in 55 of 58 nonselected patients (all three views in 32 patients, two views in 22 and one view in one); 42 of 55 patients had coronary artery disease. EF by 2-D echo was compared with EF by gated cardiac blood pool imaging in all patients (r = 0.927, SEE = 6.7%) and to EF by single-plane cineangiography (angio) in 35 of 55 patients (r = 0.913, SEE = 7.4%). LV dyssynergy was frequently present and involved the apex in 29 of 55 patients. Using angio as the standard for evaluating wall motion at the apex, 2-D echo was 100% sensitive and specific in detecting abnormal apical wall motion. We conclude that EF can be determined accurately with 2-D echo in a large group of patients with and without dyssynergy by a simple method that eliminates the need for planimetry or computer assistance.