tbuckley/cabot-search huggingface dataset:
Illness among holidaymakers and the effect on a seaside practice.
Authors: N Maskrey, J F Poppleton, D J Knowelden, L C Grahame
Journal: BMJ (1985)

Between 1 May and 30 September 1983 a practice of three doctors in the centre of Scarborough conducted 1772 consultations with 1472 temporary residents, 967 (55%) of which were during July and August. The pattern of illness differed considerably from that usually found in general practice, with an excess of minor infections, gastrointestinal upsets, and skin problems comprising 46% of the consultations. Practitioners who care for appreciable numbers of temporary residents should plan their services to match the special needs of holidaymakers. The task of doctors in areas with many visitors would be made easier if patients who are on regular medication or are under surveillance brought with them not only enough drugs for their needs but also a summary of their medical history.
My role model
Authors: L. Farrell
Journal: BMJ (1998)

We are none of us saints, and a veneer of sophistication and restraint is all that lies between us and the unbridled satiation of our most venal appetites and our most primitive drives; to eat, to survive, to have sex, to reproduce, to ensure the perpetuation of our own genes. Fighting, drinking, gambling, wanton pillage; morality is ephemeral and in another cultural milieu these activities might be looked on with undiluted admiration. Being nice to each other is just a current fad, and under the skin we are red in tooth and claw and other more sensitive body parts.

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Diffusion of Surgical Innovations, Patient Safety, and Minimally Invasive Radical Prostatectomy
Authors: J. Kellogg Parsons, Karen Messer, Kerrin Palazzi, Sean P. Stroup, David Chang
Journal: JAMA Surgery (2014)

Surgical innovations disseminate in the absence of coordinated systems to ensure their safe integration into clinical practice, potentially exposing patients to increased risk for medical error.To investigate associations of patient safety with the diffusion of minimally invasive radical prostatectomy (MIRP) resulting from the development of the da Vinci robot.A cohort study of 401 325 patients in the Nationwide Inpatient Sample who underwent radical prostatectomy during MIRP diffusion between January 1, 2003, and December 31, 2009.We used Agency for Healthcare Research and Quality Patient Safety Indicators (PSIs), which measure processes of care and surgical provider performance. We estimated the prevalence of MIRP among all prostatectomies and compared PSI incidence between MIRP and open radical prostatectomy in each year during the study. We also collected estimates of MIRP incidence attributed to the manufacturer of the da Vinci robot.Patients who underwent MIRP were more likely to be white (P = .004), have fewer comorbidities (P = .02), and have undergone surgery in higher-income areas (P = .005). The incidence of MIRP was substantially lower than da Vinci manufacturer estimates. Rapid diffusion onset occurred in 2006, when MIRP accounted for 10.4% (95% CI, 10.2-10.7) of all radical prostatectomies in the United States. In 2005, MIRP was associated with an increased adjusted risk for any PSI (adjusted odds ratio, 2.0; 95% CI, 1.1-3.7; P = .02) vs open radical prostatectomy. Stratification by hospital status demonstrated similar patterns: rapid diffusion onset among teaching hospitals occurred in 2006 (11.7%; 95% CI, 11.3-12.0), with an increased risk for PSI for MIRP in 2005 (adjusted odds ratio, 2.7; 95% CI, 1.4-5.3; P = .004), and onset among nonteaching hospitals occurred in 2008 (27.1%; 95% CI, 26.6-27.7), with an increased but nonsignificant risk for PSI in 2007 (adjusted odds ratio, 2.0; 95% CI, 0.8-5.2; P = .14).During its initial national diffusion, MIRP was associated with diminished perioperative patient safety. To promote safety and protect patients, the processes by which surgical innovations disseminate into clinical practice require refinement.
Wellcome Trust promotes ethical research in developing world
Authors: S. Hargreaves
Journal: BMJ (2002)

The Wellcome Trust this week committed £4m ($6.2m; €6.3m) to fund initiatives to promote ethically sound biomedical research in the developing world.

Anthony Tomei, director of the Nuffield Foundation and chairman of the trust's biomedical ethics panel, said in a statement: “The Nuffield Council report published earlier this year highlighted the complex issues surrounding research ethics in developing countries. We welcome the trust's initiative in launching a scheme to address these issues and encourage those who want to make a …
Cell proliferation kinetics of cultured human keratinocytes and fibroblasts measured using a monoclonal antibody
Authors: T. OKU, M. TAKIGAWA, M. YAMADA
Journal: British Journal of Dermatology (1987)

Measurements of cell cycle kinetics using an immunoperoxidase method employing monoclonal anti-bromodeoxyuridine (BrdU) antibody were compared with an autoradiographic method using [3H]-thymidine. The methods were applied to epithelial cells grown from explants of normal skin and basal cell carcinoma (BCC), and to fibroblasts from normal skin, hypertrophic scar and keloid. In normal keratinocytes the number of peroxidase-positive cells was higher than the number incorporating [3H]-thymidine, because of the presence of labelled cells in the centre of the explants in the former. The epithelial cells from BCC gave a mean (+/- SD) of 4.9 +/- 1.2% peroxidase-positive cells, while no cells were labelled with [3H]-thymidine. In dermal fibroblasts from normal skin and hypertrophic scar the percentages of peroxidase-positive cells did not differ significantly from the [3H]-thymidine labelling indices. The immunological method has advantages over [3H]-thymidine autoradiography in that it avoids radioactive material and the proportion of cells labelled by the two methods is the same.
Concordance of Diurnal Intraocular Pressure between Fellow Eyes in Primary Open-Angle Glaucoma
Authors: Robert B. Dinn, M. Bridget Zimmerman, Lesya M. Shuba, Andrew P. Doan, Michael K. Maley, Emily C. Greenlee, Wallace L.M. Alward, Young H. Kwon
Journal: Ophthalmology (2007)
Aldosterone Antagonists — Last Man Standing?
Authors: Paul W. Armstrong
Journal: New England Journal of Medicine (2010)

The transformation of cardiac care over the past half century has been breathtaking to witness. In large part, this transformation is due to the advent of new drugs and devices, improved health care systems, and behavioral modifications such as smoking cessation. Four cardiac medicines developed before 1960 that survived the turn of the millennium are aspirin, digoxin, warfarin, and spironolactone. New competitors threaten the continued longevity of aspirin, the survival of digoxin depends on evidence of its ability to improve exercise tolerance and quality of life in patients with heart failure, and new pretenders for warfarin are here. Remarkably, after . . .
Cancer in Alcoholics (Corrected Table)
Authors: Benjamin Kissin
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Dr. Bernard H. Fox from the National Cancer Institute, in a personal communication, brought to our attention some discrepancies in Table 1 of our recent article "Head and Neck Cancer in Alcoholics: The Relationship of Drinking, Smoking and Dietary Patterns" (224:1174, 1973). Upon careful investigation of the data, we realized that some changes are in order. The two matched control groups were formed by random computer selection of noncases. Unfortunately, some of the same individuals were included in both control groups, making comparisons with the second group inappropriate. In addition, one control subject had reported an unusually high alcohol intake pattern. The data from Table 1 were recomputed as shown in the revised Table, excluding the aberrant measurements of that subject from the first control group and including a new and different second control group. The differences in intake patterns were reevaluated, using a number of statistical
Newly identified particle may explain spurious platelet count
Authors: Beverly Merz
Journal: JAMA (1983)

Hematology and immunology are a lot like physics, continually witnessing discoveries of new particles that alter concepts of previously identified particles. The recent identification of a white blood cell fragment, the neutrophil pseudoplatelet—so named because it looks like a platelet and acts like a neutrophil—may be one such discovery (<i>Science</i>1983; 220:415-417). According to Jacob S. Hanker, PhD, professor of neurobiology and oral biology, University of North Carolina, Chapel Hill, and adjunct associate professor of pathology, Duke University, Durham, NC, the particle had been observed, but not identified, for some time. In an interview with<i>JAMA</i>MEDICAL NEWS he explained, "These small particles have been noted in two situations—in purulent exudate and in peripheral blood samples from leukemia patients. However, in the first case they were thought to be fragments of neutrophils and in the second case they were often mistaken for platelets themselves." Hanker also held this belief until
The anatomical foundation of neuroradiology of the brain.
Authors: John Stirling Meyer
Journal: JAMA (1963)

This slim but attractive little volume consists of 239 pages. Included are ten pages of index and six pages of bibliography (the latter is incomplete). There are eight chapters on neuroradiological anatomy, entitled "Neuroanatomy," "Pneumoencephalography and Ventriculography," "Ventricular System," "Subarachnoid Spaces," "Cerebral Angiography," "Arterial Supply of the Brain," "Venous Drainage of the Brain," and "Radiologic Illusions." The material is presented well by an experienced teacher and embryology and anatomy are especially interesting and clear. The material is well illustrated with 146 figures. The normal pneumoencephalograms and angiograms are clearly depicted. The description of the subarachnoid space and basal system is excellent. Although this book was designed specifically for the radiologist, it is recommended also to the neurologist, neurosurgeon, and anatomist. It is a valuable book particularly for residents in the clinical specialties who deal with the brain and its circulation, and is a welcome addition to the neuroroentgenological library. The
Misleading symptoms and signs of cervical spine subluxation in rheumatoid arthritis.
Authors: N Christophidis, E C Huskisson
Journal: BMJ (1982)

Radiological evidence of cervical spine subluxation is found in 30 to 40% of patients in hospital with severe deforming rheuma- toid arthritis, and of these, 2 to 5% have typical symptoms and signs of cord compression.1 2 During the past 10 years we have seen four cases in whom the presenting neurological features were atypical and misleading. Case reportsCase 1-In January 1972, a 47-year-old woman with rheuma- toid arthritis complained of three weeks of tingling down the right side, weakness of the left arm and leg, constipation, and decreased frequency of micturition.Examination confirmed weakness and exaggerated deep tendon reflexes and Babinski response on the left side.Proprioception and vibration sense were normal.Pain and temperature sense were absent over the right arm and leg, the right side of the trunk, and the neck, jaw and occiput, consistent with the diagnosis of incomplete Brown-Sequard syndrome (figure).X-ray films showed 14 mm of atlantoaxial subluxation in flexion.Myelography showed a complete block at C1/2.Atlantoaxial fusion was performed, which resulted in improved bowel and bladder function.Signs of the Brown-Sequard syndrome persisted, however.Case 2-In October 1980, a 62-year-old man with rheumatoid arthritis complained of three to four weeks of progressive numb- ness, weakness, and clumsiness in both arms and legs.On examination his arms and legs were weak and hypertonic, with exaggerated deep tendon reflexes, bilateral ankle clonus, and Babinski responses.Sensation to light touch and pin-prick was diminished over the arms and legs distally in a glove-andstocking distribution (figure).X-ray examination showed sub- luxation of C3 on C4.Myelography showed a complete block at C4. Anterior fusion of C3-5 was performed and sensation re- turned to normal.Power increased somewhat, though mild ankle clonus and upgoing plantar reflexes persisted.Case 3-In September 1980, a 70-year-old woman with rheu- matoid arthritis complained of dyspnoea beginning a few days earlier.On direct questioning she had had occipitonuchal pain For Debate . .
Primary Streptococcal Peritonitis in Pregnancy
Authors: M. D. Middleton, H. J. Solomon
Journal: BMJ (1962)

JOURNAL~~~~~~~~~~~f rom an occasional cyanotic attack gave very little trouble in rearing.The accompanying Chart illustrates her excellent progress.When discharged from the premature baby unit on May 15 she weighed 5 lb.E oz. (2,280 g.).She has been seen regularly at the follow-up clinic and her progress so far has been normal.
Gastroduodenal Polyps in Familial Adenomatous and Juvenile Polyposis
Authors: H. J. Järvinen, P. Sipponen
Journal: Endoscopy (1986)

Upper gastrointestinal endoscopy revealed gastroduodenal polyps in 45 (90 %) out of 50 patients with familial adenomatosis (FA), and in 11 (92 %) out of 12 patients with juvenile polyposis (JP). The polyps in the fundic and corpus regions of the stomach were hamartomatous cystic body gland polyps in 28 (56 %), and adenomas in 3 (6 %) of the FA patients, while 6 (50 %) JP patients had hyperplastic polyps in the corresponding region. The polyps in the gastric antrum and duodenum were adenomas in 6 (12 %) and 25 (50 %) of the FA patients, respectively, while the polyps of the corresponding regions were hyperplastic in 10 (83 %) and 2 (17 %) of the JP subjects. One focal adenomatous lesion in an antral hyperplastic polyp, and one duodenal adenoma were found in the JP patients. Furthermore, one duodenal adenocarcinoma was observed among the FA subjects. It is concluded that gastroduodenal polyps belong inherently both to adenomatous and to juvenile varieties of gastrointestinal polyposis, and that these two conditions have characteristic histological patterns and topography of polyps in the upper gastrointestinal tract.
Rosen and Barkin’s Five-Minute Emergency Medicine Consult
Authors: Benjamin Bassin
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High‐dose imatinib for newly diagnosed chronic phase chronic myeloid leukemia patients—Systematic review and meta‐analysis
Authors: Anat Gafter‐Gvili, Avi Leader, Ronit Gurion, Liat Vidal, Ron Ram, Adi Shacham‐Abulafia, Isaac Ben‐Bassat, Michael Lishner, Ofer Shpilberg, Pia Raanani
Journal: American Journal of Hematology (2011)

Imatinib at a dose of 400 mg daily is considered frontline treatment in chronic phase chronic myeloid leukemia (CP-CML). We conducted a systematic review and meta-analysis of randomized controlled trials comparing frontline treatment with imatinib 400 mg daily versus higher doses (≥600 mg daily) in patients with CP-CML. The search yielded four trials, randomizing 1,673 patients. At 12 months, high dose compared with standard dose imatinib improved complete cytogenetic response (CCyR) (RR 1.17, 95% CI 1.08-1.26, four trials, I(2) = 33%) as well as major molecular response (MMolR) (RR 1.26, 95% CI 1.12-1.42, four trials, I(2) = 0%). There was no difference in all-cause mortality or disease progression at the end of follow up. Adverse events requiring discontinuation were more common in the high-dose arm (RR 1.98, 95% CI 1.20-3.26, three trials, I(2) = 0%), as were Grade III/IV neutropenia and thrombocytopenia: RR 1.56, 95% CI 1.15-2.12 and RR 1.86, 95% CI 1.28-2.70, respectively. There is currently insufficient evidence to support the routine use of higher doses of imatinib as frontline treatment for CP-CML. Extended follow up is needed to evaluate if the superior CCyR and MMolR with higher doses of imatinib will translate to long-term clinical benefit.
THE DIAGNOSIS OF CARCINOMA OF THE LARYNX.
Authors: OTTO T. FREER
Journal: JAMA (1903)

Tubercular tumors of the larynx resemble more papilloma or fibroma than carcinoma, as they are generally strictly circumscribed, smooth, with intact mucosa, broad-based or pedunculated and arise from the surface of the larynx in the manner of the benign growths. They may be covered with papillomata. In some cases, however, where the tumor is broad-based and diffuse, it may simulate carcinoma, as in the case reported by Gussenbauer, who extirpated a larynx supposing a tubercular tumor to be a malignant one. Hajek reports five cases of tubercular tumor of the larynx, all of which occurred after the fiftieth year, so that age is of little use in the diagnosis from carcinoma. Pulmonary tuberculosis is usually but not always present, so that the microscope may be needed for the diagnosis. The very rare association of carcinoma and tuberculosis in the larynx needs only to be mentioned. The laryngeal affections of secondary
Treatment of Schizophrenia: Progress and Prospects
Authors: H. Keith Fischer
Journal: JAMA (1977)

With medical models of schizophrenias and with a variety of treatment approaches, all the complexity and diversity must be summarized from time to time to permit the clinicians to "keep up," and maintain perspective. The book consists of six parts: "Models of Schizophrenia"; "Psychopharmacologic Approaches"; "Individual Psychotherapy"; "Small Group Approaches"; "Milieu and Social Approaches"; and finally an overview. Each part has an introduction, which summarizes and focuses highlights from the respective chapters. Zubin's model of schizophrenia proposes stress, vulnerability, and symptoms if a threshold is reached. At any level a variety of factors exert influence. The editors introduce this as a "global" model, although it hardly seems so to me. Meanwhile, Kety presents a neurochemical model admitting many etiologic factors, but finally influencing the brain and its programming via catecholamine transmitters and dopaminergic systems. Mandel gives a biochemical model that considers a variety of adaptive mechanisms that affect neurotransmitter systems.
STRANGULATED SLIDING HERNIA
Authors: William Randolph Smith
Journal: JAMA (1924)

Strangulation of a sliding hernia appears to be very rare. In fact, I have been unable to find any cases of this condition reported in the literature, and a nationally known authority on the subject, who sees a vast amount of hernia work at the Hospital for the Ruptured and Crippled in New York, recently told me that he cannot recall ever having seen or heard of a case. <h3>REPORT OF CASE</h3><h3>History.</h3> —A negro, aged 29, whose family and past histories were irrelevant except in relation to the local condition, had been forced to lift a heavy load when 6 years of age. This had resulted in a bilateral inguinal hernia, for the relief of which he had since worn a truss. At times, when straining, he could feel his "ruptures" slide down into the scrotum. At other times they protruded without his noticing it, and his attention was
Quantitative single-cell characterization of CAR+ T cell effector functions
Authors: Ivan Liadi, Harjeet Singh, Gabrielle Romain, Nicolas Rey-Villamizar, Amin Merouane, Badrinath Roysam, Laurence J Cooper, Navin Varadarajan
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Adoptive cell therapy (ACT) utilizing chimeric antigen receptor (CAR) T cells rendered specific for CD19 have demonstrated significant anti-tumor effects in patients with CD19+ chronic lymphocytic leukemia (CLL). In spite of the clinical promise of ACT in achieving complete
Successful Treatment of Severe Thalassemia
Authors: P Muretto, E Angelucci
Journal: New England Journal of Medicine (1999)

Figure 1. A six-year-old girl underwent successful allogeneic bone marrow transplantation for severe β-thalassemia in 1985. Before transplantation, the serum ferritin concentration was 4044 μg per liter and the serum aspartate aminotransferase and alanine aminotransferase concentrations were respectively 6 and 13 times the upper level of the normal range. Liver biopsy showed severe iron overload (hepatic iron concentration, 24.74 mg per gram of liver, dry weight), chronic active hepatitis, and bridging fibrosis (Ishak histologic score, 3) (Panels A and B). Six years later, the patient was treated with 54 sequential phlebotomies to reduce iron overload. Ten years after transplantation, the . . .
Genetic Testing of Children: The Need for a Family Perspective
Authors: Anneke Lucassen, Guy Widdershoven, Suzanne Metselaar, Angela Fenwick, Michael Parker
Journal: The American Journal of Bioethics (2014)

It has been proposed that two recent guidelines, both endorsed by the ACMG, are in tension with each other because they result in opposing outcomes with respect to genetic testing of children for a...
Influence of tubercle aggregate size on severity of adjuvant arthritis in the rat.
Authors: S.P Liyanage, H.L Currey, B Vernon-Roberts
Journal: Annals of the Rheumatic Diseases (1975)

Incorporation into Freund's complete adjuvant of tuberculous aggregates smaller than 90 mum in size is essential to produce adjuvant arthritis in the rat, and this correlates with a significantly greater degree of cell-mediated immunity to tuberculous antigens produced by small aggregates (smaller than 90 mum), when compared with large (larger than 90 mum) aggregates. This requirement for small aggregates to render Freund's complete adjuvant arthritogenic is not paralleled by detectable differences in antimycobacterial humoral antibody production nor by a size-dependent requirement for a conventional adjuvant effect.