Zollinger-Ellison Syndrome: Provocative Diagnostic Tests
Authors: ANDREW F. IPPOLITI
Journal: Annals of Internal Medicine (1977)

Editorial Notes1 December 1977Zollinger-Ellison Syndrome: Provocative Diagnostic TestsANDREW F. IPPOLITI, M.D.ANDREW F. IPPOLITI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-6-787 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFeatures of the Zollinger-Ellison syndrome (gastrinoma) include peptic ulcer disease, basal acid hypersecretion, and fasting hypergastrinemia. Its diagnosis is strongly supported by a serum gastrin concentration above 500 pg/ml in the absence of achlorhydria or renal failure. Such marked elevations of serum gastrin are not present in all gastrinoma patients, however. About 40% will have a fasting gastrin concentration of 100 to 500 pg/ml, whereas about 10% of ulcer patients without evidence of gastrinoma have fasting gastrin concentrations in that range. Therapy for ordinary peptic ulcer differs from that for the Zollinger-Ellison syndrome medically—short-term antacid or Cimetidine treatment rather than...References1. DEVENEYDEVENEYJAFFEJONESWAY CKBRL: Use of calcium and secretin in the diagnosis of gastrinoma (Zollinger-Ellison Syndrome). Ann Intern Med 87:680-686, 1977 LinkGoogle Scholar2. LAMERSVAN TONGEREN CJ: Comparative study of the value of the calcium, secretin, and meal stimulated increase in serum gastrin to the diagnosis of the Zollinger-Ellison syndrome. Gut 18:128-134, 1977 CrossrefMedlineGoogle Scholar3. THOMPSONREEDERVILLARFENDER JDHH: Natural history and experience with diagnosis and treatment of the Zollinger-Ellison syndrome. Surg Gynecol Obstet 140:721-739, 1975 MedlineGoogle Scholar4. BRANDSBORGBRANDSBORGCHRISTENSEN OMN: Plasma adrenaline and serum gastrin: studies in insulin-induced hypoglycemia and after adrenaline infusions. Gastroenterology 68:455-460, 1975 CrossrefMedlineGoogle Scholar5. MORROWPASSARO DE: Calcium infusion test before and after total gastrectomy in the Zollinger-Ellison syndrome. Am J Surg 129:62-66, 1975 CrossrefMedlineGoogle Scholar6. WALSHGROSSMAN JM Gastrin. N Engl J Med 292:1377-1384, 1975 CrossrefMedlineGoogle Scholar7. IPPOLITIROTENBERGWALSHISENBERG AJJJ: Fasting and secretin-stimulated gastrin in patients with proven and possible gastrinoma and hyperparathyroidism (abstract). Gastroenterology 70:896, 1976 Google Scholar8. RICHARDSONWALSH CJ: The value of a histamine H2-receptor antagonist in the management of patients with the Zollinger-Ellison syndrome. N Engl J Med 294:133-135, 1976 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySerum Gastrin in Zollinger-Ellison SyndromeSerum Gastrin in Zollinger-Ellison SyndromeIndicaciones de estudios de secreción gástrica en la patología esofagogástricaZollinger-Ellison Syndrome Associated with Persistently Normal Fasting Serum Gastrin ConcentrationsM. MICHAEL WOLFE, M.D., DEVENDRA K. JAIN, Ph.D., JAMES R. EDGERTON, M.D.Islet Cell Tumors and the Ulcerogenic SyndromeThe diagnosis and treatment of gastrinoma and Zollinger-Ellison syndromeManagement of the patient presenting as an emergency with hypergastrinemiaSerum gastrin levels in response to exogenous secretin in patients with duodenal ulcerTreatment of the Zollinger-Ellison syndromeSerum gastrin response to secretin after vagotomySecretin injection test in the diagnosis of gastrinomaFalse-Positive Secretin TestROBERT L. WOLLMUTH, M.D., JAMES B. WAGONFELD, M.D. 1 December 1977Volume 87, Issue 6Page: 787-788KeywordsAchlorhydriaAttentionGastrinHypergastrinemiaPeptic ulcersRenal failureUlcersZollinger Ellison syndrome Issue Published: 1 December 1977 PDF DownloadLoading ...