tbuckley/cabot-search huggingface dataset:
Lactic Acidosis and AIDS
Authors: Marilyn T. Haupt
Journal: Annals of Internal Medicine (1993)

Letters15 August 1993Lactic Acidosis and AIDSMarilyn T. Haupt, James A. Kruse, and Richard W. CarlsonMarilyn T. HauptSearch for more papers by this author, James A. KruseSearch for more papers by this author, and Richard W. CarlsonSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-4-199308150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Chattha and associates [1] describe a group of seven human immunodeficiency virus (HIV)-infected patients with lactic acidosis in the absence of hypoxemia or another obvious cause. We suspect that sepsis may be the cause of lactic acidosis in many, if not all, of their patients. Several symptoms described in these patients, including nausea, anorexia, fever, malaise, and tachypnea, are typical of patients with sepsis.The authors stated that they ruled out sepsis by appropriate laboratory tests and diagnostic procedures and by autopsy . Patients with HIV infection frequently have sepsis from occult or unusual infections that elude ...References1. Chattha G, Arieff AI, Cummings C, Tierney LM Jr. Lactic acidosis complicating the acquired immunodeficiency syndrome. Ann Intern Med. 1993; 118:37-9. Google Scholar2. Bone RC, Fisher CJ Jr, Clemmer TP, Slotman GJ, Metz CA, Balk RA, et al. A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med. 1987; 317:653-8. Google Scholar3. Gilbert EM, Haupt MT, Mandanas RT, Huaringa AJ, Carlson RW. The effect of fluid loading, blood transfusion, and catecholamine infusion on oxygen delivery and consumption in patients with sepsis. Am Rev Respir Dis. 1986; 134:873-8. Google Scholar4. Ahmed AJ, Kruse JA, Haupt MT, Chandrasekar PH, Carlson RW. Hemodynamic response to gram-positive versus gram-negative sepsis in critically ill patients with and without circulatory shock. Crit Care Med. 1991; 19:1520-5. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAntiviral agents 15 August 1993Volume 119, Issue 4Page: 343-345KeywordsHIVHIV infectionsHypoxiaLaboratory testsLactic acidLactic acidosisNauseaOxygenSepsisTachypnea Issue Published: 15 August 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Use of hemostatic powder (Hemospray) in the management of refractory gastric variceal hemorrhage
Authors: A. Stanley, L. Smith, A. Morris
Journal: Endoscopy (2013)

Hemospray (Cook Medical, Winston – Salem, North Carolina, USA) is a novel powder licensed for endoscopic treatment of nonvariceal upper gastrointestinal bleeding (UGIB). It acts by forming a barrier over the bleeding site, increasing local concentration of clotting factors and activating the intrinsic clotting cascade [1]. Hemospray has been shown to be effective in peptic ulcer bleeding and other nonvariceal sources of UGIB [2] [3] [4] [5]. We report its use in the management of gastric variceal bleeding refractory to injection of Histoacryl (n-butyl cyanoacrylate; Braun Medical, Sheffield, UK), acting as a bridge towards a transjugular intrahepatic portosystemic shunt (TIPS) procedure.
Smoking and Wrinkles: Does It Matter?
Authors: Thomas E. Kottke
Journal: Annals of Internal Medicine (1991)

Editorials15 May 1991Smoking and Wrinkles: Does It Matter?Thomas E. Kottke, MDThomas E. Kottke, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-10-908 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn this issue, Kadunce and colleagues (1) report that smoking is associated with wrinkles. Importantly, the association is independent of age, exposure to the sun, and level of pigmentation. Many readers will undoubtedly respond, "So what? Nobody ever died of crow's feet. Why doesn't the Annals focus on the really impressive effects of smoking—the death and the disability?"Doctors are impressed by the death and disability caused by smoking because they see it first hand. Some patients will also respond to the message that smoking kills and maims. However, many patients will find the threat of death so remote that...References1. KadunceBurrGressKannerLyonZone DRRRJJ. Cigarette smoking: risk factor for premature facial wrinkling. Ann Intern Med. 1991;114:840-4. LinkGoogle Scholar2. BeckerMaiman ML. Sociobehavioral determinants of compliance with health and medical care recommendations. Med Care. 1975;13:10-24. CrossrefMedlineGoogle Scholar3. SilvisPerry GC. Understanding and deterring tobacco use among adolescents. Pediatr Clin North Am. 1987;34:363-79. CrossrefMedlineGoogle Scholar4. Rogers E. Diffusion of Innovations. 3d ed. New York: The Free Press;1983:319. Google Scholar5. Alinsky S. Rules for Radicals. New York: Vintage Books; 1972:68. Google Scholar6. Booth G. Think Good Thoughts about a Pussycat. New York: Dodd, Mead & Company; 1975. Google Scholar7. . The Health Benefits of Smoking Cessation. Rockville, Maryland: U. S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health. DHHS Publication no. (CDC) 90-8416; 1990:i. Google Scholar8. HoweWesthoffVesseyYeates GCMD. Effects of age, cigarette smoking, and other factors on fertility: findings of a large prospective study. BMJ. 1985;290:1697-700. CrossrefMedlineGoogle Scholar9. KottkeBattistaDeFrieseBrekke TRGM. Attributes of successful smoking cessation interventions in medical practice. A meta-analysis of 39 controlled trials. JAMA. 1988;259:2883-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Thomas E. Kottke, MDAffiliations: MSPH Mayo Clinic and Foundation Rochester, MN 55905 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEffect of Smoking and Sun on the Aging SkinCutaneous manifestations and consequences of smokingCigarette Smoking and Facial WrinklingIan Joffe, MD 15 May 1991Volume 114, Issue 10Page: 908-909KeywordsDisabilities ePublished: 1 December 2008 Issue Published: 15 May 1991 PDF downloadLoading ...
Inflammation and Atherosclerosis
Authors: Tracy Hampton
Journal: JAMA (2012)

Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an ongoing inflammatory response.Recent advances in basic science have established a fundamental role for inflammation in mediating all stages of this disease from initiation through progression and, ultimately, the thrombotic complications of atherosclerosis.These new findings provide important links between risk factors and the mechanisms of atherogenesis.Clinical studies have shown that this emerging biology of inflammation in atherosclerosis applies directly to human patients.Elevation in markers of inflammation predicts outcomes of patients with acute coronary syndromes, independently of myocardial damage.In addition, low-grade chronic inflammation, as indicated by levels of the inflammatory marker C-reactive protein, prospectively defines risk of atherosclerotic complications, thus adding to prognostic information provided by traditional risk factors.Moreover, certain treatments that reduce coronary risk also limit inflammation.In the case of lipid lowering with statins, this anti-inflammatory effect does not appear to correlate with reduction in low-density lipoprotein levels.These new insights into inflammation in atherosclerosis not only increase our understanding of this disease, but also have practical clinical applications in risk stratification and targeting of therapy for this scourge of growing worldwide importance.(
Organization and function of an accident flying squad.
Authors: J. Collins
Journal: BMJ (1966)

Medical Emigration-Seale each subsequent year it has fallen at an accelerating rate.By 1965 there were 750 fewer general practitioners than in 1960, nearly all of the fall occurring after 1962.In the early 1950s, on the other hand, the general practitioners were increasing by 300 to 400 per year.The number of consultants (excluding honorary staff and locumtenents) in England and Wales increased by 1,034 between 1962 and 1965, but this was largely offset by a fall of 933 in the number of senior hospital medical officers in the same period.In 1960 there were 8,100 junior hospital doctors of registrar grade or below in England and Wales.By 1965 the number had risen by 2,100, but 1,750 of this increase was due to an increase in doctors born outside the British Isles.Between 1962 and 1965 the number of British-born doctors of junior hospital grades fell by 80.The increasing dependence of the hospital service upon doctors from overseas is shown by the fact that in 1960 2,890 junior hospital doctors in England and Wales were born outside the British Isles (360/, of the total), but by 1965 the number from overseas had risen to 4,650 (460% of the total).Large-scale medical emigration has been a significant aspect of British medicine for over 10 years, and is now a major factor contributing to the dwindling supply of fully trained medical manpower in Britain.In 1964 Professor Abel-Smith wrote that the loss by emigration of the equivalent of nearly onequarter of the output of the medical schools " can be regarded as a serious matter."In the year 1965 the rate appears to have risen to one-third of the output of the schools.
Book Review Dermatology Second edition. By Otto Braun-Falco, Gerd Plewig, Helmut H. Wolff, and Walter H.C. Burgdorf. 1853 pp., illustrated. New York, Springer-Verlag, 2000. $235. 3-540-59452-3
Authors: Christopher E.M. Griffiths
Journal: New England Journal of Medicine (2001)
Health Care at Mass Gatherings
Authors: Gary B. Green
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outcome of colectomy for severe idiopathic constipation.
Authors: M A Kamm, P R Hawley, J E Lennard-Jones
Journal: Gut (1988)

Severe idiopathic constipation affects predominantly young women. We have evaluated the results of colectomy in 44 women with a normal diameter colon and with a median bowel frequency of once per four weeks. The operations were done in one hospital over a 15 year period. After operation 22 patients had normal bowel frequency, 17 diarrhoea (greater than three bowel actions/day), and five persistent or recurrent constipation (interval between bowel actions at least three days). Many patients continued to experience abdominal pain (98% preoperatively v 71% postoperatively); straining and laxative use were still common after surgery. Ten patients needed psychiatric treatment for severe psychological disorders. The preoperative abnormalities of paradoxical contraction of the pelvic floor during straining and impaired rectal evacuation of a water filled balloon did not correlate with the outcome.
Differentiation syndrome in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline chemotherapy: characteristics, outcome, and prognostic factors
Authors: Pau Montesinos, Juan M. Bergua, Edo Vellenga, Chelo Rayón, Ricardo Parody, Javier de la Serna, Angel León, Jordi Esteve, Gustavo Milone, Guillermo Debén, Concha Rivas, Marcos González, Mar Tormo, Joaquín Díaz-Mediavilla, Jose D. González, Silvia Negri, Elena Amutio, Salut Brunet, Bob Lowenberg, Miguel A. Sanz
Journal: Blood (2008)
Measurement of serum bilirubin and its mono- and diconjugates: application to patients with hepatobiliary disease.
Authors: B F Scharschmidt, N Blanckaert, F A Farina, P M Kabra, B E Stafford, R A Weisiger
Journal: Gut (1982)

A technique has recently been described by Blanckaert and his colleagues that specifically and accurately quantifies unconjugated bilirubin, diconjugated bilirubin, and the C-8 and C-12 isomers of monoconjugated bilirubin. This technique has now been used to determine the distribution pattern of bilirubin and its ester conjugates in 91 sera from 65 patients with hepatobiliary disease, and the results were compared with two conventional diazo assays. Both diazo assays yielded values for total bilirubin concentration that were markedly and unpredictably higher than those obtained by the new technique, and the direct-reacting fraction by diazo assay showed little or no agreement with the fraction of total ester conjugates determined by the new method. Previous studies using the new method had shown that bilirubin conjugates are undetectable in sera from healthy adults or individuals with Gilbert9s syndrome, but they were found in 89 of the 91 present patient sera. The fraction of total serum bilirubin represented by C-8 monoconjugates, C-12 monoconjugates, diconjugates, and total ester conjugates was higher in patients with biliary obstruction than in those with parenchymal liver disease, but extensive overlap between groups prevented determination of these conjugated species from being diagnostically useful. Overall, bilirubin ester conjugates in serum consisted of 30% C-8 monoconjugates, 37% C-12 monoconjugates, and 33% diconjugates, while urine contained predominantly diconjugates.
Miguel de Cervantes, hydropsy, and Thomas Sydenham
Authors: B. Simini
Journal: BMJ (2001)

One day during the spring of 1616, as three friends quickly rode their horses from Esquivias to Madrid, a student hurried behind on a donkey and begged them to slow down. As they did so one of the gentlemen told the student that “Senor Miguel de Cervantes' fast mount” was the reason for their swift pace. The student, recognising Cervantes' paralysed hand, addressed him with admiration and devotion. The four resumed their journey and Cervantes wrote, “We talked about my disease,” and quoted the student saying, “Your malady is hydropsy, something which cannot heal even if you were to drink as much sweet water as there is salt water in the entire ocean … Senor Cervantes, …
Report of the Task Force on the Availability of Cardiovascular Drugs to the Medically Indigent.
Authors: H P Dustan, L R Caplan, C L Curry, A C De Leon, F L Douglas, W Frishman, M N Hill, R L Washington, S Steigerwalt, N B Shulman
Journal: Circulation (1992)

It is more prevalent in blacks than in whites.' * It is the major risk factor for strokes and contrib- utes significantly to heart attacks.It is the major cause of end stage renal disease in blacks.* Medications account for an estimated 20% of the national cost of hypertension, in contrast to other cardiovascular diseases, for which these costs rep- resent a lower fraction of the total (Figure 1).End Stage Renal Disease * It is a major public health problem that is fatal without dialysis or kidney transplantation.* Its most frequent causes are hypertension and diabetes.* Blacks are disproportionately affected: although they represent 12.3% of the US population, they com- prise 28.3% of end stage renal disease patients.2* Adequate treatment of hypertension has been shown to slow the rate of decline in kidney function in patients who already have damaged kidneys.* Medicare End Stage Renal Disease programs fund much of the cost of dialysis and kidney transplantation.In 1988 Medicare's contribution to that cost was 67%, representing $3.7 billion.Stroke * 500,000 Americans are afflicted each year.' * 2,980,000 Americans have had strokes.* It is estimated that in 1992 stroke will result in $2.6 billion in lost productivity.* It is more prevalent in poor people than in the affluent (National Center for Health Statistics, personal communication [unpublished data from Health Interview Studies], September 1990) * It is more prevalent in blacks than in whites.' * Stroke accounts for one half of all patients hospi- talized for acute neurological diseases.
Methodological suggestions for climato-economic theory
Authors: Kwok Leung, Grand H.-L. Cheng
Journal: Behavioral and Brain Sciences (2013)

Abstract To evaluate and extend climato-economic theory, the use of more micro units of analysis, such as cities and families, may open up new data sources. The consideration of environmental demands other than thermal climate may also broaden the range of useful data. Longitudinal designs can provide causal evidence, and so can experiments if the theory can be applied to individuals.
Angina Pectoris with Normal Coronary Arteries in Renal Failure
Authors: MERCÈ PONS
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 October 1980Angina Pectoris with Normal Coronary Arteries in Renal FailureMERCÈ PONS, M.D., JESÚS MONTOLIU, M.D., ANGEL CASTAÑER, M.D., JOSÉ LÓPEZ-PEDRET, M.D., LUIS REVERT, M.D.MERCÈ PONS, M.D.Search for more papers by this author, JESÚS MONTOLIU, M.D.Search for more papers by this author, ANGEL CASTAÑER, M.D.Search for more papers by this author, JOSÉ LÓPEZ-PEDRET, M.D.Search for more papers by this author, LUIS REVERT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-4-640_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the April issue, Dr. Francis and coworkers presented their results of coronary artery bypass surgery in dialysis patients and reviewed previous literature on that subject (1). All of these patients, when studied by coronary angiogram, have had obstructive lesions of the coronary arteries. Little attention has been directed towards the possibility that dialysis patients might have angina pectoris or myocardial infarction with normal coronary arteries, as has been well recognized in other population groups (2). In that respect, we have recently seen a 36-year-old woman with terminal renal failure due to proliferative glomerulonephritis and malignant hypertension...References1. FRANCISSHARMACOLLINSHELSETHCOMTY GBAHC. Coronary artery surgery in patients with end-stage renal disease. Ann Intern Med. 1980;92:499-503. LinkGoogle Scholar2. RAIZNERCHAHINE AR. Myocardial infarction with normal coronary arteries. In: HURST JW, LOGUE RB, SCHLANT RC, WENGER NK. The Heart. 4th ed. New York: McGraw-Hill Book Co.; 1980:147-66. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MERCÈ PONS, M.D.; JESÚS MONTOLIU, M.D.; ANGEL CASTAÑER, M.D.; JOSÉ LÓPEZ-PEDRET, M.D.; LUIS REVERT, M.D.Affiliations: Hospital Clinico y Provincial Barcelona-36 Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1980Volume 93, Issue 4Page: 640-640KeywordsAnginaAngiographyCoronary arteriesGlomerulonephritisHypertensionLesionsMedical dialysisMyocardial infarctionRenal failureSurgery ePublished: 1 December 2008 Issue Published: 1 October 1980 PDF downloadLoading ...
Long term prognosis in ulcerative colitis--based on results from a regional patient group from the county of Copenhagen.
Authors: C Hendriksen, S Kreiner, V Binder
Journal: Gut (1985)

The prognosis of ulcerative colitis including survival, colectomy rate, activity of disease, and working capacity was estimated from a follow up study of 783 patients with ulcerative colitis comprising all patients from the county of Copenhagen, except for the island of Amager, diagnosed between 1960 and 1978. The period of observation ranged from one to 18 years with a median of 6.7 years for the clinical observations, eight years for survival and 11.6 years for the occurrence of large bowel cancer. The follow up was 100% for both survival and cancer. The survival rate in women did not differ from that in the general population. In men over 40 years of age at diagnosis a slight excess mortality was found, but only in the year of diagnosis (2.1%) and the following year (1.5%). Colonic cancer was seen in only seven out of the 783 patients, corresponding to an annual risk of 0.07% and a cumulative risk after 18 years with ulcerative colitis of 1.4% (95% confidence limits, 0.7-2.8%) independent of the initial extent of disease. The colectomy rate was 9.6% in the year of diagnosis. The cumulative 10- and 18-year colectomy rate was 23% and 31%, respectively. After three years from diagnosis the capacity for work both in those subject to resection and treated conservatively did not differ significantly from that in the background population. At any time about 50% of the patients were without symptoms, in about 30% the disease activity was low and in about 20% moderate or high. Most patients, however, differed in activity from one year to another and almost all patients (97%) experienced at least one relapse during a 10 year time period.
Neurological Deficits Following the Hot Bath Test in Multiple Sclerosis-Reply
Authors: Joseph R. Berger
Journal: JAMA (1985)

<h3>In Reply.—</h3> We appreciate the comments of Dr Davis concerning our article. We agree that deficits observed in patients with MS might simply reflect a magnification of an acute exacerbation by the hyperthermia with incomplete resolution. This possibility does not negate the mechanisms previously discussed.<sup>1-4</sup>We wish to emphasize that at the time of hot bath testing, our patients were either free of objective evidence of neurological disease (case 1) or had new neurological symptoms for two weeks or longer (cases 2, 3, and 4). In none was the diagnosis of MS initially clear-cut. The frequency with which we see exacerbations following environmental heat exposure, as compared with Northern centers, impresses us that heat itself is a factor. In recent months, we have seen several additional patients experiencing prolonged neurological sequelae following exposure to high environmental temperature. Of these additional patients, five interesting exampies are described. Three of these
177 MAINTENANCE REGIME WITH TACROLIMUS ≤ 1 MG/DAY AFTER LIVER TRANSPLANTATION IN ADULTS: EVALUATION FROM 5 TO 18 YEARS AFTER THE FIRST TRANPLANTATION
Authors: J.R. Bernuau, A. Pironti, C. Francoz, A. Plessier, V. Paradis, F. Dondero, D. Sommacale, J. Belghiti, D. Valla, F. Durand
Journal: Journal of Hepatology (2008)