Skeletal Sclerosis Due to Chronic Fluoride Intoxication
Authors: HENRY A. AZAR
Journal: Annals of Internal Medicine (1961)

Article1 August 1961Skeletal Sclerosis Due to Chronic Fluoride IntoxicationCases from an Endemic Area of Fluorosis in the Region of the Persian GulfHENRY A. AZAR, M.D., CHARLES K. NUCHO, M.D., SHIBLI I. BAYYUK, B.SC., M.SC., WARDIH B. BAYYUK, B.SC.HENRY A. AZAR, M.D.Search for more papers by this author, CHARLES K. NUCHO, M.D.Search for more papers by this author, SHIBLI I. BAYYUK, B.SC., M.SC.Search for more papers by this author, WARDIH B. BAYYUK, B.SC.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-2-193 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChronic fluoride intoxication, as manifested by mottling of tooth enamel and diffuse osteosclerosis, has been observed throughout the world in communities in which the domestic water supply contained fluoride in concentrations usually in excess of four parts per million (1-5). On the other hand, a series of well-coordinated investigations in the United States has supported the concept that no clinically significant, adverse, physiological, or functional effects, with the exception of dental fluorosis, are to be anticipated in persons whose water supply contains fluoride in the concentration of 8 ppm (6). In a recent review of approximately 170,000 roentgenologic examinations of...References1. KILBORNOUTERBRIDGELEI LGTSHP: Fluorosis with report of an advanced case. Canad. Med. Ass. J. 62: 135, 1950. MedlineGoogle Scholar2. SIDDIQUI AH: Fluorosis in Nalgonda District, Hyderabad, Deccan. Brit. Med. J. 2: 1408, 1955. CrossrefMedlineGoogle Scholar3. FICHARDTVAN RHYNVAN SELM TJLGW: A case of fluorosis. J. Fac. Radiol. (Lond.) 7: 130, 1955. CrossrefMedlineGoogle Scholar4. STEVENSONWATSON CAAR: Roentgenologic findings in fluoride osteosclerosis. Arch. Industr. Health 21: 340, 1960. MedlineGoogle Scholar5. PRINCI F: Fluorides: a critical review. III. The effects on man of the absorption of fluoride. J. Occup. Med. 2: 92, 1960. MedlineGoogle Scholar6. LEONE NC: The effects of the absorption of fluoride. I. Outline and summary. Arch. Industr. Health 21: 324, 1960. MedlineGoogle Scholar7. FISHER SN: Americana Annual 1960. Americana Corporation, New York, 1960. Google Scholar8. WILLARDWINTER HHOB: Volumetric method for the determination of fluorine. Industr. Engin. Chem. Analyt. Ed. 5: 7, 1933. CrossrefGoogle Scholar9. . Standard Methods for the Examination of Water, Sewage, and Industrial Wastes, 10th Ed., American Public Health Association, Inc., 1955, p. 98. Google Scholar10. JACKSONWEIDMANN DSM: Fluorine in human bone related to age and the water supply of different regions. J. Path. Bact. 76: 451, 1958. CrossrefMedlineGoogle Scholar11. CLAWSONKHALIFAHPERKS MDESAJ: Chronic endemic dental fluorosis (mottled enamel). J. Amer. Dent. Ass. 27: 1569, 1940. CrossrefGoogle Scholar12. EL TANNIR MD: Mottling of enamel in Mecca and the Arabian Peninsula: a survey and research study carried out in Saudi Arabia. Amer. J. Public Health 49: 45, 1959. CrossrefGoogle Scholar13. FARAH J: Personal communication, 1959. Google Scholar14. CHOLAK J: Fluorides: a critical review. I. The occurrence of fluoride in air, food and water. J. Occup. Med. 1: 501, 1959. CrossrefGoogle Scholar15. ROHOLM K: Fluorine Intoxication. A Clinico-Hygienic Study with a Review of the Literature and Some Experimental Investigations. H. K. Lewis and Co., Ltd., London, 1937. Google Scholar16. WEATHERELLWEIDMANN JASM: The skeletal changes of chronic experimental fluorosis. J. Path. Bact. 78: 233, 1959. CrossrefMedlineGoogle Scholar17. WEIDMANNWEATHERELL SMJA: The uptake and distribution of fluorine in bones. J. Path. Bact. 78: 243, 1959. CrossrefMedlineGoogle Scholar18. WEIDMANNWEATHERELLWHITE-HEAD SMJARG: The effect of fluorine on the chemical composition and calcification of bone. J. Path. Bact. 78: 435, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Beirut,Received for publication March 31, 1961.From the Departments of Pathology and Chemistry, American University of Beirut, Beirut, Lebanon, and Hamlin Hospital for Chest Diseases, Hammana, Lebanon.Requests for reprints should be addressed to Henry A. Azar, M.D., Assistant Professor of Pathology, Francis Delafield Hospital, 99 Fort Washington Avenue, New York 32, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBlack Tea Source, Production, and Consumption: Assessment of Health Risks of Fluoride Intake in New ZealandCyanobacteria and cyanotoxins are present in drinking water impoundments and groundwater wells in desert environmentsTotal Knee Arthroplasty in a Patient With Skeletal FluorosisMeasurement of Fluoride-Induced Endoplasmic Reticulum Stress Using Gaussia LuciferaseThe Acid Test of Fluoride: How pH Modulates ToxicityFluoride and health hazards: community perception in a fluorotic area of central Rajasthan (India): an arid environmentPaleopathology of skeletal fluorosisLettersEndemic fluorosisSerum haptoglobin and C-reactive protein in human skeletal fluorosisFluoride and flouridationFluoride and bone: an unusual hypothesisToxische OsteopathienFluoridbestimmung in Knochenproben vom menschlichen Beckenkamm mit einer ionenselektiven ElektrodeDie Bedeutung der Beckenkammpunktion mit histologischer und mikroanalytischer Untersuchung des gewonnenen Knochenmaterials bei der Diagnostik der FluoroseGiant Cells in Bone Marrows of Patients on High-Dose Fluoride TreatmentPAUL H. DUFFEY, M.D., F.A.C.P., HAROLD C. TRETBAR, M.D., THADDEUS L. JARKOWSKI, M.D.Endemic skeletal fluorosisBone Turnover and OsteoporosisOsteofluorosis in the rabbit: Macroscopic and radiographic changesEndemic fluorosis in Punjab (India)Myeloma of bone treated with sodium fluorideChronic Fluoride Intoxication with Fluorotic RadiculomyelopathyBERTRAM J. L. SAUERBRUNN, M.D., CHARLES M. RYAN, M.D., F.A.C.P., JAMES F. SHAW, M.D. 1 August 1961Volume 55, Issue 2Page: 193-200KeywordsAttentionIntoxicationMalnutritionPhosphatasesThoraxTuberculosis Issue Published: 1 August 1961 PDF downloadLoading ...