tbuckley/cabot-search huggingface dataset:
Abstract P1-01-08: Diagnostic accuracy of pre-operative ultrasonographic evaluation of axillary lymph nodes in breast cancer patients: Is there a place for axillary ultrasonography in future nomograms?
Authors: AM Moorman, R Bourez, D de Leeuw, EA Kouwenhoven
Journal: Cancer Research (2013)

Abstract Background During the years there has been a significant interest in the development of clinical prediction tools to estimate the risk of having positive lymph nodes in the axilla, and thereby making it possible to plan specific therapies. A non-invasive and widely available method is axillary ultrasonography. Aim The purpose of this study was to evaluate the diagnostic accuracy of axillary ultrasonography. Patients and methods Between January 2007 and July 2011, pre-operative axillary ultrasonography was performed in 1124 consecutive primary breast cancer patients who underwent surgery with sentinel node biopsy (SNB) and/or complete axillary lymph node dissection (ALND). Suspected lymph nodes (cortex thickness &amp;gt; 2.3 mm) were further analysed by cytology or histology. In case of a negative axillary ultrasonography, standard SNB was performed during operation. In case of suspected lymph nodes with axillary ultrasonography, confirmed by biopsy, routine complete ALND was performed. Results Of the 1124 patients, 922 (82%) had unsuspected lymph nodes and 202 (18%) had suspicious lymph nodes during axillary ultrasonography. The sensitivity and specificity of axillary ultrasonography was 46.6% and 93.0% respectively in case of a macrometastases. In all cases of suspected malignancy, axillary core biopsy was performed. The sensitivity and specificity of axillary ultrasonography in combination with core biopsy was 40.5% and 97.2% respectively. With increasing number of axillary nodes the sensitivity increases: 53.9% in case of 2 macrometastases and 83.3% in case of 3 macrometastases. Conclusion Ultrasonography and core biopsy are effective in predicting the presence of axillary metastases in breast cancer patients. Especially the high specificity might be of additional value for future nomograms in the surgical treatment of breast cancer patients. In addition, the sensitivity is of greater value in case of gross nodal disease. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P1-01-08.
Abstract 2722: Characteristics of pancreatic cancer spheroids as a model for anticancer efficacy test.
Authors: Sang-Eun Yeon, Sang-Hoon Lee, Hyo-Jeong Kuh
Journal: Cancer Research (2013)

Abstract Compared to the conventional monolayers or suspension cultures, 3D culture models have drawn attention as a vivo-mimic model which can produce clinically relevant data. Among the several types of 3D culture models, multicellular spheroid (MCS) is a appropriate model for study of penetration and efficacy of anticancer agents. Purpose of this study was to establish MCS of human pancreatic cancer cell (Panc-1) and evaluate its usefulness as anticancer efficacy test. Panc-1 MCS was produced successfully by using poly-dimethylsiloxane(PDMS) microwell instead of agarose-coated 96-well system. MCS with average diameter of 375 μm was prepared in 700 μm microwells after 4 days of culture. Spherical morphology with rather rough surface and junctional structures in outer cell layers were observed with no notable necrotic area. Extracellular matrix proteins such as collagen I, fibronectin, and laminin were detected in the interstitial space of MCS. Stem cell population with CD44+/CD24+/ESA+ expression increased from 0.1% to 2.1% when cultured as MCS. miRNA expression profiling showed a difference between monolayers and MCS, i.e., 36 and 85 genes were up- and down-regulated in MCS, respectively. Imaging of drug penetration and viability indicators including MitoSOX, Edu incorporation, and Ki-67 expression were optimized for microwell format. Colorimetric assays of MTS and APH were performed after transferring MCS to 96-well plates. Overall, we demonstrated that PDMS microwell is an appropriate platform for preparation of MCS of Panc-1 cells and MCS showed different biological features from monolayers, suggesting that Panc-1 MCS prepared using PDMS microwell may be a useful 3D model for anticancer efficacy test. Citation Format: Sang-Eun Yeon, Sang-Hoon Lee, Hyo-Jeong Kuh. Characteristics of pancreatic cancer spheroids as a model for anticancer efficacy test. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2722. doi:10.1158/1538-7445.AM2013-2722 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
Thyrotoxicosis, Cryofibrinogenemia, Sinutab Maximum Strength, and Purple Ears
Authors: John Kellett
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 April 1989Thyrotoxicosis, Cryofibrinogenemia, Sinutab Maximum Strength, and Purple EarsJohn Kellett, MDJohn Kellett, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-8-668 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:In April 1988 a 45-year-old white woman presented with mild symptoms of recurrent thyrotoxicosis. Propylthiouracil, 100 mg three times a day, with which she had been treated 3 years previously, was restarted. One month later ampicillin and Sinutab Maximum Strength were prescribed for a mild upper respiratory infection. Two hours after starting both medications, the patient noted a "tingling" and redness in the pinae of both ears. Over the next 12 hours her ears became progressively more cold, purple, and intensely painful. She was otherwise well, with no rash or cyanosis of hands or feet, and no...References1. SmithArkin SC. Cryofibrinogenaemia: incidence, clinical correlation, and a review of the literature. Am J Clin Pathol. 1972;58:524-30. CrossrefMedlineGoogle Scholar2. McKeeKalbfleischBird PJR. Incidence and significance of cryofibrinogenemia. J Lab Clin Med. 1963;61:203-10. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Western Memorial Regional Hospital Newfoundland Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA paediatric case of granulomatosis with polyangiitis accompanied with dorsalis pedis artery occlusion and prominent cryofibrinogenaemiaA 5-year prospective follow-up study in essential cryofibrinogenemia patientsCryofibrinogenaemia: a study of 49 patients 15 April 1989Volume 110, Issue 8Page: 668-669KeywordsRashesUpper respiratory tract infections Issue Published: 15 April 1989 PDF DownloadLoading ...
Declining Case Fatality Rates for Severe Sepsis
Authors: Theodore J. Iwashyna, Derek C. Angus
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 5078: FGFR2 gene amplification status in gastric carcinoma and clinicopathologic significance
Authors: Eun-Jung Jung, Woo Ho Kim, Eun-Ji Jung, Min A. Kim
Journal: Cancer Research (2010)

Abstract Background: Fibroblast growth factor receptor 2 (FRFG2) is a member of FGFR receptor tyrosine kinase family. FGFR2 gene amplification or missense mutation has been observed in various human cancers, including gastric carcinoma. Recent studies showed that, anti FGFR2 agents inhibit tumor progression in other tumors. Gastric carcinoma is one of the most frequent causes of cancer-related death worldwide. Evaluate the status of FGFR2 gene amplification in gastric carcinoma is beneficial in targeted cancer therapy. Methods: We evaluated FGFR2 amplification status in the surgically resected 312 gastric carcinoma cases, using fluorescence in situ hybridization (FISH) and real-time quantitative-polymerase chain reaction (q-PCR), and compared the results. We compared clinicopathologic parameters with the presence of FGFR2 amplification, and performed survival analysis. Results: Among 312cases, 14 cases (4.5%) showed FGFR2 amplification by FISH. FGFR2 amplification was associated to higher pT stage (p=0.015), pN stage (p=0.031) and distant metastasis (p=0.023). In survival analysis, FGFR2 amplification was significantly associated with lower cancer-specific survival in univariate analysis (p=0.012). The Real-time q-PCR results were concord with the FISH result. Conclusions: Gastric carcinoma with FGFR2 amplification showed more advanced disease and poor survival. Evaluate the FGFR2 amplification status may identify a subset of cancers that are sensitive to targeted therapy using FGFR2 inhibitors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5078.
Transient paraplegia due to dissecting aortic aneurysm.
Authors: I M Stewart, P A Millac
Journal: BMJ (1973)

this problem we have collected the following information.In November 1972, 5,165 patients were sent for a radiological examination at the Radclffe Infirmary; 2,158 were females, and 181 of these who were between the ages of 15 and 45 years had examinations of the abdomen and pelvic regions.At the Nuffield Orthopaedic Centre for the same month the total was 1,321 patients; 702 were females and 87 of these between the ages of 15 and 45 had eamntions of the abdomen and
Childhood mortality varies threefold across different UK local authorities, report shows
Authors: N. Hawkes
Journal: BMJ (2013)

The United Kingdom should feel “profoundly ashamed” of its record on child health, the chief medical officer for England has said. 

Much more needed to be done for regional variation to be eliminated and for national performance to match that achieved by the best countries in Europe, Sally Davies told a press conference to introduce a new report on the health of young people up to the age of 25.1 Some of the statistics, she asserted, were “absolutely shocking.”

She said that five more children under the age of 14 die every day than would be the case if the UK matched the death rate in Sweden, which has the lowest rate in 11 European countries, and that childhood mortality between the ages of 12 months and 17 years varied threefold across different local authorities in the UK. …
A NEW GROOVED ASPIRATOR NEEDLE.
Authors: J.A. DIBRELL
Journal: JAMA (1896)

In a case of suspected pelvic abscess, I introduced an aspirator needle for diagnostic purposes, and finding pus, I incised the vaginal mucous membrane at the base of the needle with the intention of conducting along the round needle a director, and in the groove of this instrument a narrow scissors with the view of so dilating the opening that I could insert a drainage tube, irrigate and secure drainage. Though the director was rather sharp pointed, the result was to push it out of the abscess wall. It occurred to me that an aspirator needle could be made with a groove like a director for use in similar cases, and when the presence of pus or other accumulations are found, that the grooved director needle could be used without removal, to conduct a knife, scissors or other instruments for dilatation, and the introduction of drainage tubes. I submitted a
Plasma Testosterone Levels before, during and after Chronic Marihuana Smoking
Authors: Jack H. Mendelson, John Kuehnle, James Ellingboe, Thomas F. Babor
Journal: New England Journal of Medicine (1974)

To test the relation between chronic marihuana use and testosterone levels, we studied 27 men, 21 to 26 years of age. Plasma testosterone was measured daily before, during, and after a 21-day period of marihuana use. The mean pre-use testosterone level of 12 casual users (who smoked an average of 54 marihuana cigarettes during the 21-day use period) was 988±93 ng per 100 ml (±S.E.M.), and that of 15 heavy users, who smoked an average of 119 cigarettes, was 1115±69 ng per 100 ml. No statistically significant changes in plasma testosterone levels were observed during and after the smoking period as compared with the pre-smoking base-line levels. These data do not corroborate an association between chronic marihuana use and decreased plasma testosterone. (N Engl J Med 291:1051–1055, 1974)
The biological speciation and toxicokinetics of aluminum.
Authors: E DeVoto, R A Yokel
Journal: Environmental Health Perspectives (1994)

This review discusses recent literature on the chemical and physiological factors that influence the absorption, distribution, and excretion of aluminum in mammals, with particular regard to gastrointestinal absorption and speciation in plasma. Humans encounter aluminum, a ubiquitous yet highly insoluble element in most forms, in foods, drinking water, and pharmaceuticals. Exposure also occurs by inhalation of dust and aerosols, particularly in occupational settings. Absorption from the gut depends largely on pH and the presence of complexing ligands, particularly carboxylic acids, with which the metal can form absorbable neutral aluminum species. Uremic animals and humans experience higher than normal body burdens of aluminum despite increased urinary clearance of the metal. In plasma, 80-90% of aluminum binds to transferrin, an iron-transport protein for which receptors exist in many tissue. The remaining fraction of plasma aluminum takes the form of small-molecule hydroxy species and small complexes with carboxylic acids, phosphate, and, to a much lesser degree, amino acids. Most of these species have not been observed in vivo but are predicted from equilibrium models derived from potentiometric methods and NMR investigations. These models predict that the major small-molecule aluminum species under plasma conditions are charged and hence unavailable for uptake into tissues.
Endothelium-dependent relaxation to aggregating platelets in isolated basilar arteries of control and hypercholesterolemic pigs.
Authors: H Shimokawa, P Kim, P M Vanhoutte
Journal: Circulation Research (1988)

The role of the endothelium was examined in the response to aggregating platelets in cerebral arteries from normal and hypercholesterolemic animals. Male Yorkshire pigs were fed either a normal diet or a 2% high-cholesterol diet for 10 weeks. Endothelium-dependent responses were examined in vitro. In rings of basilar arteries from control animals aggregating platelets caused endothelium-dependent relaxations, which were significantly inhibited by apyrase, an adenosine diphosphatase and triphosphatase, but were augmented by methiothepin, a combined S1- and S2-serotonergic blocker. In quiescent rings platelets induced contractions that were inhibited by the presence of the endothelium; these contractions were significantly inhibited by methiothepin, but not by ketanserin (an S2-serotonergic blocker) or dazoxiben (a thromboxane-synthetase blocker) in the presence or absence of SQ29548 (a thromboxane-receptor blocker). Adenosine diphosphate but not serotonin caused endothelium-dependent relaxations. In cholesterol-fed animals the endothelium-dependent relaxations in response to aggregating platelets and adenosine diphosphate were impaired. These experiments indicate that 1) the endothelium inhibits the vasoconstrictor effect of aggregating platelets in porcine cerebral arteries; 2) platelet-induced relaxations are achieved mainly by a purinergic mechanism, while platelet-induced contractions are mediated by activation of S1-serotonergic receptors with little contribution of thromboxanes; and 3) hypercholesterolemia impairs the endothelium-dependent relaxations in response to aggregating platelets due to the impaired responses to adenosine diphosphate.
People are living longer but are not in best health, global study finds
Authors: A. Gulland
Journal: BMJ (2012)

The biggest ever study of people’s health worldwide has found that the number of deaths of children under the age of 5 years fell by 60% between 1970 and 2010, but that of adults aged 15-49 rose by 44%, largely because of increases in violence and HIV and AIDS. 

The Global Burden of Disease Study 2010, funded by the Bill and Melinda Gates Foundation and led by the Institute for Health Metrics and Evaluation at the University of Washington, involved 486 authors from 302 institutions in 50 countries and delivered 650 million results.

Publishing in an entire issue of the Lancet (http://bit.ly/XkYEvr), researchers looked at 300 diseases, injuries, and risk factors and found that there were just 50 causes for 78% of the global disease burden.1

They found that life expectancy rose …
Left Ventricular Volumes in Valvular Heart Disease
Authors: JOHN W. JONES, CHARLES E. RACKLEY, ROBERT A. BRUCE, HAROLD T. DODGE, LEONARD A. COBB, HAROLD SANDLER
Journal: Circulation (1964)

Left ventricular volumes were determined in 86 patients with aortic and mitral valve disease by use of a biplane angiocardiographic technic in conjunction with cardiac catheterization. Total stroke output of the left ventricle was grossly increased by severe degrees of valvular incompetence. Although both end-systolic and total stroke volume varied directly with the end-diastolic volume, there was no correlation between end-diastolic pressure and either total stroke volume or end-diastolic volume.
Trans-Repressive Effect of NUP98-PMX1 on PMX1-Regulated c-<i>FOS</i> Gene through Recruitment of Histone Deacetylase 1 by FG Repeats
Authors: Xue-Tao Bai, Bai-Wei Gu, Tong Yin, Chao Niu, Xiao-Dong Xi, Ji Zhang, Zhu Chen, Sai-Juan Chen
Journal: Cancer Research (2006)

Abstract The formation of fusion genes between NUP98 and members of the HOX family represents a critical factor for the genesis of acute leukemia or acute transformation of chronic myeloid leukemia (CML). To gain insights into the molecular mechanisms underlying the leukemogenesis of NUP98-HOX fusion products, we cloned NUP98-PMX1 from a CML-blast crisis patient with t(1;11) as a secondary chromosomal translocation, and functionally studied the fusion products in detail through various molecular and protein biochemical assays. In addition to many interesting features, we have found that the NUP98-PMX1 fusion protein exerts a repressive effect on PMX1 or serum response factor–mediated c-FOS activation, probably through the recruitment of a common corepressor histone deacetylase 1 by FG domains of the NUP98-PMX1 fusion protein. Moreover, we have provided evidence that the FG domains of NUP98-PMX1 and two other NUP98-containing fusion proteins, i.e., NUP98-HOXA9 and NUP98-HOXC11, all exhibit dual binding ability to both CREB binding protein, a coactivator, and histone deacetylase 1, a corepressor. Accordingly, we have hypothesized that this dual binding activity is shared by most, if not all, NUP98-HOX-involved fusion proteins, enabling these fusion proteins to act as both trans-activators and trans-repressors, and contributing to the genesis of acute leukemia or acute transformation of CML. (Cancer Res 2006; 66(9): 4584-90)
Serum carotenoids and coronary heart disease. The Lipid Research Clinics Coronary Primary Prevention Trial and Follow-up Study
Authors: D. L. Morris
Journal: JAMA (1994)

<h3>Objective.</h3> —To examine the relationship between total serum carotenoid levels and the risk of subsequent coronary heart disease (CHD) events. <h3>Design.</h3> —New analysis of a cohort from the Lipid Research Clinics Coronary Primary Prevention Trial and Follow-up Study (LRC-CPPT). The LRC-CPPT was a multicenter placebo-controlled trial of cholestyramine resin and CHD with a follow-up period of 13 years. Serum carotenoids were measured at baseline. <h3>Participants.</h3> —The placebo group of the LRC-CPPT, which consisted of 1899 men aged 40 to 59 years with type II-a hyperlipidemia and without known preexisting CHD, cancer, or other major illnesses. <h3>Main Outcome Measures.</h3> —Nonfatal myocardial infarctions and deaths attributable to CHD ascertained from hospital records, autopsy reports, and death certificates and reviewed by a panel of cardiologists. <h3>Results.</h3> —After adjustment for known CHD risk factors including smoking, serum carotenoids were inversely related to CHD events. Men in the highest quartile of serum carotenoids had an adjusted relative risk (RR) of 0.64 (95% confidence interval [CI], 0.44 to 0.92) compared with the lowest quartile. For men who never smoked, this RR was 0.28 (95% CI, 0.11 to 0.73). <h3>Conclusions.</h3> —The LRC-CPPT participants with higher serum carotenoid levels had a decreased risk of incident CHD. This finding was stronger among men who never smoked. (<i>JAMA</i>. 1994;272:1439-1441)