TOLERANCE AND TOXICITY OF INSULIN
Authors: FREDERICK M. ALLEN
Journal: Annals of Internal Medicine (1939)

Article1 May 1939TOLERANCE AND TOXICITY OF INSULINIII. PROTAMINE AND ZINC COMPOUNDS*FREDERICK M. ALLEN, M.D.FREDERICK M. ALLEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-11-1870 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCompletion of the desired range of experiments was prevented by circumstances. The material used was the regular preparation of protamine zinc insulin as supplied by Eli Lilly & Co. for clinical use. The results, though fragmentary, establish several new facts, as follows.I. PROTAMINE INSULIN WITH SPONTANEOUS EATINGThese observations were limited to rats. As mentioned in the previous paper, it has never been possible to produce extreme obesity in adult animals of any species with regular insulin. MacKay and Callaway1have recently reported the interesting discovery that this can be accomplished in rats with doses of about eight...References1. MACKAYCALLAWAY EMJW: Hyperalimentation in normal animals produced by protamine insulin, Proc. Soc. Exper. Biol. and Med., 1937, xxxvi, 406. CrossrefGoogle Scholar2. LONGWELLRAVIN BBA: The effect of intravenous administration of protamine insulin, Am. Jr. Physiol., 1936, cxvii, 453. CrossrefGoogle Scholar3. LAWRENCEARCHER RDN: Some experiments with protamine insulinate, Brit. Med. Jr., 1936, i, 747. CrossrefGoogle Scholar4. SPRAGUERYNEARSON RGEH: Insulin with prolonged action, Proc. Staff Meet. Mayo Clin., 1937, xii, 246. Google Scholar5. PATELRÖNMARK RPB: The action of protamine insulin in rabbits in relation to its standardization, Quart. Jr. Pharm. and Pharmacol., 1936, ix, 679. Google Scholar6. WILDERWILBUR RNDL: Diseases of metabolism and nutrition; review of certain recent contributions, Arch. Int. Med., 1937, lix, 329. CrossrefGoogle Scholar7. BISCHOFFJEMTEGAARD FLM: Divided dosage of insulin, Am. Jr. Physiol., 1937, cxix, 149. CrossrefGoogle Scholar8. BARACH JH: Crystalline insulin, ANN. INT. MED., 1937, x, 1335. Google Scholar9. ALLEN FM: Studies concerning glycosuria and diabetes, 1913, Harvard University Press, Cambridge. CrossrefGoogle Scholar10. BOWCOCKWILKINSON HC: Solution of zinc-insulin crystals versus regular insulin and protamine zinc insulin, Jr. Med. Assoc., Georgia, 1938, xxvii, 351. BOWCOCK, H.: Solution of zinc-insulin crystals—a new therapeutic agent, Ibid., 361. ALTSHULER, S. S., and LEISER, R.: The use of crystalline insulin in the treatment of patients with severe diabetes, Jr. Michigan State Med. Soc., 1938, xxxvii, 980. FEINBLATT, H. M.: Crystalline insulin therapy, Med. Rec., 1938, cxlviii, 380. SHEPARDSON, H. C., and FRIEDLANDER, R. D.: Clinical experiences with long-acting insulin in ambulatory diabetic patients, ANN. INT. MED., 1938, xii, 830. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FREDERICK M. ALLEN, M.D.Affiliations: New York, N. Y.*Received for publication February 26, 1938.From St. Michael's Hospital, Newark, New Jersey.This work was assisted by a fund contributed by friends of St. Michael's Hospital, for which thanks are expressed to the donors. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1939Volume 12, Issue 11Page: 1870-1885KeywordsInsulinObesityProtaminesToxicityZinc ePublished: 1 December 2008 Issue Published: 1 May 1939 PDF downloadLoading ...