tbuckley/cabot-search huggingface dataset:
WANTED: 21st Century Physician
Authors: Faith Fitzgerald
Journal: Annals of Internal Medicine (1996)

Ad Libitum1 January 1996WANTED: 21st Century PhysicianFaith Fitzgerald, MDFaith Fitzgerald, MDUniversity of California, Davis, Medical Center Sacramento, CA 95817Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-1_Part_1-199601010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Altruistic, compassionate, courageous, intellectually curious, frugal scholar, gifted in history, philosophy, politics, economics, sociology, and psychology. Must have working knowledge of biology, chemistry, physics, and medicine. Physical endurance, emotional maturity, and technical-manual skills sufficient to take apart and reassemble the human body and mind at levels ranging from the micromolecular to the gross are required; must have flexibility to master all knowledge, sift and discard that no longer applicable, while discovering new data at the bench, in clinical practice, in both general and subspecialty medicine. Teaching, counseling, administrative, computer, and budgetary expertise essential, as is commitment to the disenfranchised. A ... Author, Article, and Disclosure InformationAffiliations: University of California, Davis, Medical Center Sacramento, CA 95817Corresponding Author: Faith Fitzgerald, MD, University of California, Davis, Medical Center, 4150 V Street, Suite 3100, Sacramento, CA 95817. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1996Volume 124, Issue 1_Part_1Page: 71KeywordsComputersEmotionsIntensive care unitsPsychologySub-specialty care Issue Published: 1 January 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Plasmapheresis with Plasma Exchange in Hepatic Coma.
Authors: Michael J. Lepore
Journal: Annals of Internal Medicine (1969)

s1 May 1969Plasmapheresis with Plasma Exchange in Hepatic Coma.Michael J. Lepore, M.D., F.A.C.P., Anthony J. Martel, M.D.Michael J. Lepore, M.D., F.A.C.P.Search for more papers by this author, Anthony J. Martel, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1069_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFailure of patients in hepatic coma to respond to hemodialysis or peritoneal dialysis and their improvement after exchange transfusions suggests that a protein-bound nondialyzable factor may be involved. Such a factor might be removed selectively by bleeding the patient, separating and discarding his plasma, and returning to him his own red cells plus fresh, frozen human plasma—that is, plasmapheresis with plasma exchange.We have used this technique in a series of patients with severe hepatic disease. This report describes our experience with this procedure in four patients in hepatic coma due to fulminant, massive hepatic necrosis. All four patients were... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1069-1069KeywordsBlood plasmaCellsComaHemorrhageNecrosisPeritoneal dialysisProteins Issue Published: 1 May 1969 PDF DownloadLoading ...
P931 EFFECTS OF NON-SELECTIVE β-BLOCKERS (NSBB) ON HEMODYNAMICS AND PARACENTESIS INDUCED CIRCULATORY DYSFUNCTION IN CIRRHOTIC PATIENTS UNDERGOING LARGE VOLUME PARACENTESIS (LVP)
Authors: A. Ferrarese, A. Zanetto, P. Angeli, E. Casiglia, S. Fasolato, G. Boschetti, K.I. Rodriguez-Castro, E. Nadal, I. Bortoluzzi, G. Germani, F.P. Russo, P. Burra, M. Senzolo
Journal: Journal of Hepatology (2014)
Patients taking selegiline may have received more levodopa than necessary
Authors: C W. Olanow, J. H Godbold, W. Koller
Journal: BMJ (1996)

Effect ofadding selegiline to levodopa in early, mild Parkinson's disease Other studies have not shown increased mortality EDrTOR,-AS the manufacturers of selegiline, we were surprised to learn that the study by the Parkinson's Disease Research Group of the United Kingdom suggested increased mortality in patients given combination treatment of levodopa plus selegiline.'No increased mortality has been shown in other controlled studies with the same objectives.We have gathered data from 10 controlled, long term studies (some published, some continuing; in seven the duration of treatment was at least 3-5 years); 963 patients received selegiline alone or with levodopa and 1093 received placebo or other antiparkinsonian drugs.The mortality was 2-8% and 3 3%, respectively (table 1).When only data from the studies of at least 3-5 years' treatment were analysed the mortality was 5-2% for the selegiline group and 5 5% for the control group.No differences in the causes of death between the two groups were found.Table 1-Overall mortality in 10 controlled, long term clinical studies of selegiline in Parkinson's disease Selegiline Control group group All studies: Total No of patients 963 1093 No (%) of deaths 27 (2-8) 36 (3-3)Studies of -3-5 years' treatment:Total No of patients 524 658No (%) of deaths 27 (5-2) 36 (5-5)
A Case of Embolectomy
Authors: C. Gordon-Watson
Journal: BMJ (1926)

A CASE OF BMBOLECTOMY.Il m 1ouuu'a fetid odour.The caecum lay on the left side of the abdomen, with a retrocaecal appendix.The tense ascending colon -passed from left to right across the fourth part of the duodenum, under cover of coils of ileum.The transverse colon lay coiled under the dilated stomach on the left side.The descending and pelvic colons and the rectum were normally situated and attached.Between the pylorus and the splenic flexure of the colon there was no direct attachment of the intestines to the posterior abdominal wall.The duodenum had a mesentery.There was acute torsion of the third part of the duodenum, and, round this point as axis, there had been a volvulus of the entire gut distal to the third part of.the duodenum and .proximal to the middle of the tr ansver se colon.The superior mesenferic artery was twisted spirally round the third and fourth parts of the duodenum.The presence of the artery, together with the acute torsion, effectually obstructed the lumen of the gut at this part.The vascular lumen was apparently also partially, or completely, obstructed.
Imported Tropical Diseases
Authors: D. A. C. Price
Journal: BMJ (1967)

<h3>Background</h3> Sound measurement properties of outcome tools are essential when evaluating outcomes of an intervention, in clinical practice and in research. <h3>Purpose</h3> The purpose of this study was to review the evidence on reliability, measurement error, and responsiveness of measures of gait function in children with neuromuscular diagnoses. <h3>Data Sources</h3> The MEDLINE, CINAHL, EMBASE, and PsycINFO databases were searched up to June 15, 2012. <h3>Study Selection</h3> Studies evaluating reliability, measurement error, or responsiveness of measures of gait function in 1- to 18-year-old children and youth with neuromuscular diagnoses were included. <h3>Data Extraction</h3> Quality of the studies was independently rated by 2 raters using a modified COnsensus-based Standards for the selection of health status Measurement INstruments (COSMIN) checklist. Studies with a fair quality rating or better were considered for best evidence synthesis. <h3>Data Synthesis</h3> Regarding the methodological quality, 32 out of 35 reliability studies, all of the 13 measurement error studies, and 5 out of 10 responsiveness studies were of fair or good quality. Best evidence synthesis revealed moderate to strong evidence for reliability for several measures in children and youth with cerebral palsy (CP) but was limited or unknown in other diagnoses. The Functional Mobility Scale (FMS) and the Gross Motor Function Measure (GMFM) dimension E showed limited positive evidence for responsiveness in children with CP, but it was unknown or controversial in other diagnoses. No information was reported on the minimal important change; thus, evidence on measurement error remained undetermined. <h3>Limitations</h3> As studies on validity were not included in the review, a comprehensive appraisal of the best available gait-related outcome measure per diagnosis is not possible. <h3>Conclusions</h3> There is moderate to strong evidence on reliability for several measures of gait function in children and youth with CP, whereas evidence on responsiveness exists only for the FMS and the GMFM dimension E.
Household surface lead dust: its accumulation in vacant homes.
Authors: J W Sayre, M D Katzel
Journal: Environmental Health Perspectives (1979)

House dust has been suspected as a source of lead in the exposure of children, particularly those whose blood lead levels are in the moderately elevated range. The means by which household surface lead accumulates is at present not clear. By towel wipe sampling, 24 vacant houses in urban Rochester and Buffalo, New York, were examined for lead content on windowsills, floors, and other surfaces. High yields of lead were obtained from windowsills and floor areas adjacent windows. When washed and resampled, these areas yielded greatly reduced lead values. It is suggested that surface lead may represent a deposit phenomenon. The entry of exterior airborne particulate lead around the loose-fitting windows of older homes appears possible.
TCT-47 Two-Year Clinical Outcome of the TWENTE Trial, a Randomized Controlled Trial Comparing Second-Generation Zotarolimus-Eluting Resolute Stents Versus Everolimus-Eluting Xience V Stents in Real-World Patients
Authors: Clemens von Birgelen, Kenneth Tandjung, Hanim Sen, Mounir Basalus, J. Hans Louwerenburg, Martin Stoel, K. Gert van Houwelingen, Gerard Linssen, Salah Saïd, Mark Nienhuis, Marije Löwik, Job van der Palen, Patrick Verhorst, Frits de Man
Journal: Journal of the American College of Cardiology (2012)
APPENDICITIS COMPLICATING OVARIAN CYST AND SIMULATING TORSION OF THE PEDICLE, WITH THREE CASES.
Authors: X. O. WERDER
Journal: JAMA (1898)

Appendicitis as a complication of an ovarian cyst and accompanied by symptoms strongly resembling those of torsion of the pedicle, does not seem to be of very frequent occurrence; at least I have failed to find any cases recorded in the literature at my disposal. This is my excuse for reporting the following cases which came under my observation and in which the symptoms were supposed to be due to an axial rotation of the tumor when, on the operating table, an appendicitis was discovered to be the disturbing element which led to a wrong diagnosis. <h3>Case 1.</h3> —Mrs. C., age 56 years, mother of nine children; one miscarriage; last confinement sixteen years ago, followed by fever; otherwise always healthy. Her present trouble dates from May, 1894, when she was seized with cramps in the abdomen and vomiting, which continued for several days. She had at times most of her
<i>WT1</i> Synonymous Single Nucleotide Polymorphism rs16754 Correlates With Higher mRNA Expression and Predicts Significantly Improved Outcome in Favorable-Risk Pediatric Acute Myeloid Leukemia: A Report From the Children's Oncology Group
Authors: Phoenix A. Ho, Julia Kuhn, Robert B. Gerbing, Jessica A. Pollard, Rong Zeng, Kristen L. Miller, Nyla A. Heerema, Susana C. Raimondi, Betsy A. Hirsch, Janet L. Franklin, Beverly Lange, Alan S. Gamis, Todd A. Alonzo, Soheil Meshinchi
Journal: Journal of Clinical Oncology (2010)

To analyze the prevalence and clinical implications of Wilms' tumor 1 (WT1) single nucleotide polymorphism (SNP) rs16754 in the context of other prognostic markers in pediatric acute myeloid leukemia (AML).Available diagnostic marrow specimens (n = 790) from 1,328 patients enrolled in three consecutive Children's Cancer Group/Children's Oncology Group trials were analyzed for the presence of SNP rs16754. SNP status was correlated with disease characteristics, WT1 expression level, and clinical outcome.SNP rs16754 was present in 229 (29%) of 790 patients. The SNP was significantly more common in Asian and Hispanic patients and less common in white patients (P < .001). SNP rs16754 was also less common in patients with inv(16) (P = .043) and more common in patients with -5/del(5q) (P = .047). WT1 expression levels were significantly higher in patients with rs16754 or with WT1 mutations compared with WT1 wild-type patients (P = .021). Five-year overall survival (OS) for patients with and without the SNP was 60% and 50%, respectively (P = .031). Prognostic assessment by risk group demonstrated that in patients with low-risk disease, OS for those with and without SNP rs16754 was 90% versus 64% (P < .001) with a corresponding disease-free survival of 72% versus 53% (P = .041).The presence of SNP rs16754 was an independent predictor of improved OS; outcome differences were most pronounced in the low-risk subgroup. The high prevalence of WT1 SNP rs16754, and its correlation with improved outcome, identifies WT1 SNP rs16754 as a potentially important molecular marker of prognosis in pediatric AML.
Differential expression of non‐major histocompatibility complex‐restricted cytotoxicity in patients with granular lymphocyte‐proliferative disorders associated with or unassociated with severe anemia
Authors: Kazuo Oshimi, Yoko Oshimi, Toshiko Motoji, Hideaki Mizoguchi
Journal: American Journal of Hematology (1992)

Abstract Of 27 patients with granular lymphocyte‐proliferative disorders (GLPD), 18 patients had CD3 + T‐cell‐lineage GLPD (T‐GLPD), and 9 patients had CD3 − CD16 + natural killer (NK) cell‐lineage GLPD (NK‐GLPD). In 9 of the 18 patients with T‐GLPD, severe anemia of ≦7.5 g/dl hemoglobin (mean 5.4 g/dl) and erythroid hypoplasia in the bone marrow developed, while the remaining 9 patients with T‐GLPD and 9 patients with NK‐GLPD exhibited hemoglobin levels of ≧10.0 g/dl, and erythroid hypoplasia was not found. The number of leukocytes, neutrophils, lymphocytes or granular lymphocytes in the peripheral blood, or the percentage of lymphocytes in the bone marrow did not differ significantly between the patients with T‐GLPD associated with severe anemia and those with T‐GLPD not associated with severe anemia, and the immunophenotypes of peripheral blood mononuclear cells (PBMC) were not significantly different either. However, when non‐major histocom‐patibility complex (MHC)‐restricted cytotoxicity was assayed with PBMC, T‐GLPD patients with severe anemia and NK‐GLPD patients exhibited significantly higher levels of non‐MHC‐restricted cytotoxicity than T‐GLPD patients without severe anemia. Because PBMC obtained from T‐GLPD patients with severe anemia were shown not to lyse erythroblasts directly, the possibility that patient PBMC lyse erythroblasts in the bone marrow and thus cause anemia seems unlikely. The pathogenesis of anemia in GLPD was discussed. © 1992 Wiley‐Liss, Inc.
Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids
Authors: Mami Matano, Shoichi Date, Mariko Shimokawa, Ai Takano, Masayuki Fujii, Yuki Ohta, Toshiaki Watanabe, Takanori Kanai, Toshiro Sato
Journal: Nature Medicine (2015)
Biomarkers for the prediction of liver fibrosis in patients with chronic alcoholic liver disease
Authors: Sylvie Naveau, Bruno Raynard, Vlad Ratziu, Annie Abella, Françoise Imbert–bismut, Djamila Messous, Fabienne Beuzen, FrédÉrique Capron, Dominique Thabut, Mona Munteanu, Jean Claude Chaput, Thierry Poynard
Journal: Clinical Gastroenterology and Hepatology (2005)
Physiotherapy compared with advice for low back pain: … but at no point compared physiotherapy with chiropractic
Authors: Richard Bartley
Journal: BMJ (2004)

Physiotherapy compared with advice for low back painTargeting "physical factors" alone is not evidence based practice Editor-Frost et al's conclusion that "routine physiotherapy" based on physical factors was no more effective than one session of assessment and advice from a physiotherapist in the management of low back pain is not surprising. 1 But the defensive nature of the responses to this research is. 2 3 This defensiveness arises partly from the perceived rivalry between healthcare professions managing low back pain and the attention grabbing headlines used.In recent years the evidence base has highlighted that low back pain is a multifaceted phenomenon incorporating physical impairment, psychological distress, and social interruption.Thus the effective biopsychosocial management of low back pain should reflect its multifaceted nature and not just focus on the "physical factors," as was done by Frost et al.Being an evidence based practitioner should entail identifying and managing patients' risk factors because risk factors are clinical predictors of outcome and efforts to manage them may reduce the burden of low back pain for those who consult physiotherapists.Because of the recurrent nature of low back pain, talk of a "cure" is unrealistic.Thus the Physiotherapy Pain Association emphasises that patients should be taught skills to self manage their low back problem so that in the long term they are less likely to experience pain related disability and depression, thus improving their quality of life.Receiving passive treatments focusing on physical factors, which show only slight short term benefits, is not in the personal or economic interest of patients with low back pain.As is highlighted by the responses to the study by Frost et al, 3 beliefs about treatment preferences for low back pain vary across professions and can be traced to beliefs about the cause of the problem.
Evolution of haplotypes at CCL3L1/CCL4L1
Authors: Somwang Janyakhantikul, Danielle Carpenter, John AL Armour
Journal: Genome biology (2010)

Background CCL3L1 and CCL4L1 are chemokine genes, located on chromosome 17q12 (Figure 1). They are copy number variable genes that share 95% sequence identity with their non-copy number variable paralogues CCL3 and CCL4 [1]. The copy number (CN) of these genes varies between populations [2] and has been shown to be associated with phenotypes, such as susceptibility to HIV infection [2] and SLE [3]. A CCL3L1 pseudogene, also known as CCL3L2, is present in the CCL3L1 region. This pseudogene has sequences similar to CCL3L1 gene, but lacks exon 1 of CCL3L1. As a result, its presence might affect copy number (CN) measurement and subsequent interpretations in association studies between CCL3L1 CN and diseases [4]. The copy number of CCL3L1/CCL4L1 was measured using paralogue ratio test (PRT) in 270 HapMap samples 192 UK samples and 157 Basques samples [5]. Firstly, we examined the association between the presence of the CCL3L1 pseudogene and CCL3L1 CN in the UK samples and HapMap samples by PCR. The pseudogene was found in 52 out of 192 (27.08%) of UK samples. The presence of this pseudogene is strongly associated with higher copy number of CCL3L1/CCL4L1 (P<1 × 10) (Figure 2). The presence of the pseudogene was tested in all HapMap populations (Table 1). SNP genotyping and CCL3 microsatellite assays were then carried out to define a set of flanking markers that may predict CCL3L1/ CCL4L1 CN in UK and Basque samples. The best combination of 2 flanking SNPs, rs16972085 and rs8064426, can be used to predict the CCL3L1/CCL4L1 CN in UK and Basque samples with only 70% accuracy. Although the CCL3 microsatellite alleles are not associated with CCL3L1/CCL4L1 copy number, there is extensive allelic diversity in the microsatellite. Finally, to improve the accuracy of CCL3L1/CCL4L1 CN prediction, the CCL3L1/CCL4L1 genes were sequenced in 90 CEU samples to identify sequence variants within the copy-variable genes themselves. Analysis of CCL3L1/CCL41 haplotypes in CEU samples is underway to provide information on evolution of the CCL3L1/CCL4L1 haplotypes and the relationship between these haplotypes, flanking SNPs and the presence of the CCL3L1 pseudogene.
Influence of Small-Bowel Transit Time on Dietary Cholesterol Absorption in Human Beings
Authors: Maurizio Ponz de Leon, Rossella Iori, Giuliano Barbolini, Guglielmo Pompei, Paolo Zaniol, Nicola Carulli
Journal: New England Journal of Medicine (1982)

ALTHOUGH the individual steps in the absorptive process of cholesterol have been studied in great detail in recent years,1 , 2 there is still relatively little information on the factors regulating and influencing cholesterol absorption. Recent studies have shown that in certain guinea pigs that are resistant to the pathologic effect of dietary cholesterol, intestinal transit time is more rapid than in other guinea pigs that become hypercholesterolemic, suggesting that intestinal transit time allows less absorption of cholesterol in the former group, thus limiting cholesterol accumulation in body tissues.3 In view of these findings, it seemed of interest to investigate the relation . . .
AN INTERESTING CASE OF ACRANIUS.
Authors: H. H. THOMPSON
Journal: JAMA (1906)

ing vigorously, she can cause no pull on the upper lip.The tension device is entirely distinct from the wound dressing proper, is constant in its action and one application usually suffices for the entire period of wound healing.The nutrition of the lip is not interfered with from pressure.The wound is always accessible for ob- servation, dressing or cleaning.A separate dressing may be applied to the wound, although my own preference has always been to leave it entirely uncovered and to New method of dressing after hare-lip operation to secure cleanli- ness and to prevent tension.
UK doctors move towards general practice and flexible working
Authors: Madeleine Brettingham
Journal: BMJ (2005)

A surge of interest in general practice and a movement towards flexible working are among the findings of a 10 year study of UK doctors' careers. The study also notes the rise of the so called portfolio career, in which doctors dip among job types and specialties.

The BMA's cohort study, which was set up to monitor the career progression of almost 600 doctors who qualified in 1995, came to an end last week. As well as chronicling the frustrations experienced by the average trainee doctor, …
TWO CASES OF RUPTURED DUODENAL ULCER: WITH A NOTE ON THE EFFECT OF POSTURE ON THE LOSS OF LIVER DULLNESS
Authors: J. Clay
Journal: BMJ (1906)

RUPTURED DUODENAL ULCER.[JUNk 9, x9o6 derness, some muscular rigidity, and dullness on percussion ; but on deep palpation the outline of the distended and thickened caecum could be distinctly felt, With this attack there was no haemorrhage and little mucus in the stools, but there was at one time aphthous stomatitis, an occasional con- comitant of colitis.There were no signs of appendicitis, and it was evident that the condition was one of pericolitis dextra; this slowly improved under treatment, though the walls of the caecum and ascending colon are still abnormally thick, and the whole colon is dilated.