tbuckley/cabot-search huggingface dataset:
Sports Medicine and Arthroscopy Review
Authors: James Hill
Journal: JAMA (1995)

<i>Sports Medicine and Arthroscopy Review</i>devotes each issue to a particular topic in the title areas. The editors, Drs Cannon and DeHaven, are highly respected in the field. They have organized an outstanding editorial board for the journal with members who are considered to be some of the top arthroscopists and sports medicine researchers from Canada, Sweden, Japan, and the United States. An expert guest editor coordinates each issue and invites authors to submit relevant review articles. This new journal features review articles that report on the cutting edge of research and technology in sports medicine and arthroscopy. It also provides information on accepted therapeutic practices in a manner easily assimilated by busy practitioners. Articles cover all aspects of a condition, including diagnosis, etiology, research findings, operative techniques, and conservative care. This efficient format allows clinicians to find everything they need to know about the topic. The first six thematic
Blood eosinophils, eosinophil‐derived proteins, and leukotriene C<sub>4</sub> generation in relation to bronchial hyperreactivity in children with atopic dermatitis
Authors: U. Schauer, M. Trube, R. Jäger, U. Gieler, C. H. L. Rieger
Journal: Allergy (1995)

To assess the relation among eosinophil‐related variables in the peripheral blood, bronchial hyperreactivity, and the presence of atopic dermatitis in children aged 5–14 years, we studied 11 patients with atopic dermatitis alone, six with asthma and atopic dermatitis, 12 with asthma alone, and 12 healthy controls. Eosinophil counts, levels of eosinophil cationic protein, and the capacity of eosinophils to generate leukotriene (LT) C 4 , as well as bronchial hyperreactivity and a severity score for atopic dermatitis, were determined. Eosinophil variables were significantly higher in both patient groups with atopic dermatitis than in normal controls. In particular, ionophore A 23187 LTC 4 generation was higher in patients with atopic dermatitis alone (median 82, range 25–273 ng/10 6 cells) and patients with combined asthma and atopic dermatitis (median 68, range 32–583 ng/10 6 cells) than in normal controls (median 9, range 1–67 ng/10 6 cells). However, there was no difference between the group of atopic dermatitis patients with asthma and without asthma. We conclude that eosinophil variables in the peripheral blood are mainly influenced by the presence of atopic dermatitis, and not the presence and the severity of asthma in patients with both asthma and atopic dermatitis.
Pathology of the Fetus and the Infant
Authors: Jay Bernstein
Journal: JAMA (1976)

The first edition of Potter's<i>Pathology of the Fetus and the Newborn</i>(1952), as a landmark in pediatric pathology, helped to found the fledgling discipline of neonatal medicine. In 1961, the second edition appeared with its title changed to take in diseases of infancy beyond the newborn period. The second edition was, despite the intellectual ferment of the times, remarkably lacking in controversy. Much of the same, placid air pervades this third edition. The book opens with several important chapters on general pathology. One on antenatal growth brims over with essential data. I would single out for special comment the chapter on postmortem techniques, which is clear and precise. Of the other chapters on general pathology, the one on metabolic abnormalities deals superficially with too many diseases, some of them rarely encountered in early infancy. The chapter on malformations is also superficial, and both might have been enhanced by the
Ia-bearing T lymphocytes in man. Their identification and role in the generation of allogeneic helper activity.
Authors: S M Fu, N Chiorazzi, C Y Wang, G Montrazeri, H G Kunkel, H S Ko, A B Gottlieb
Journal: The Journal of Experimental Medicine (1978)

The presence of Ia-like antigens was demonstrated on a small population (2-6%) of highly purified human circulating T lymphocytes by immunofluorescence with a rabbit anti-Ia serum raised against the isolated bimolecular Ia structure. The Ia+ T lymphocytes have no surface or intracellular immunoglobulins. The expansion of this Ia+ T-cell population was encountered in certain patients. Ia antigens were also found on T blasts grown in long-term cultures with conditioned medium generated by phytohemagglutinin-stimulated lymphocytes. In addition, leukemia blasts which stained for Ia antigens and formed E rosettes were identified in the peripheral blood of two leukemic patients. This evidence further supports the existence of Ia-bearing T cells in man. The Ia+ T-lymphocyte population was shown to contain cells responsible for the generation of allogeneic helper activity. Elimination of Ia+ lymphocytes from a purified T-cell population by the anti-Ia antiserum and complement abolished its ability to help an allogeneic B-cell preparation to generate plaque-forming cells against sheep erythrocytes in vitro in the presence of the antigen.
From the Medical Board of the National Psoriasis Foundation: The risk of cardiovascular disease in individuals with psoriasis and the potential impact of current therapies
Authors: Jeremy Hugh, Abby S. Van Voorhees, Rajiv I. Nijhawan, Jerry Bagel, Mark Lebwohl, Andrew Blauvelt, Sylvia Hsu, Jeffrey M. Weinberg
Journal: Journal of the American Academy of Dermatology (2013)
Extrathalamic Modulation of Cortical Function
Authors: S L Foote, J H Morrison
Journal: Annual Review of Neuroscience (1987)

Abstract : The goal of the proposed studies is to characterize the effects of noradrenergic (NA) afferents on cortical information processing. our previous studies indicate that the primate locus coeruleus (LC) system, originating in the pontine brainstem, innervates neocortex more densely than previously thought, exhibiting highly specific patterns in terms of the regional and laminar distribution of its axons. our previous neurophysiological observations suggest that this system imposes state-related modulatory effects on thalamo- cortical and cortico-cortical systems. The proposed studies have the following Specific Aims: (1) To examine, in monkeys, the effects of manipulating the LC-NA system on ERPs, EEG characteristics, and associated behaviors in operant paradigms that utilize visual or auditory cues; (2) To correlate the activities of individual monkey LC-NA neurons with cortical neuronal activity and the measures utilized in Aim 1; (3) To extend our preliminary observation that activation of the LC by local drug infusion, in halothane-anesthetized rats, produces EEG signs of cortical and hippocampal activation; (4) To examine the relationship between the intensity of LC neuronal activity and rates of norepinephrine release in neocortex and hippocampus by performing microdialysis in these forebrain terminal regions in anesthetized rats during manipulation of LC activity.
NUT Midline Carcinoma: An Aggressive Intrathoracic Neoplasm
Authors: Sameer A. Parikh, Christopher A. French, Brian A. Costello, Randolph S. Marks, Roxana S. Dronca, Craig L. Nerby, Anja C. Roden, Vijay G. Peddareddigari, John Hilton, Geoffrey I. Shapiro, Julian R. Molina
Journal: Journal of Thoracic Oncology (2013)
Abstract 3930: Radiation-induced dicentrics: Tracking by parallel sequencing
Authors: Andrew T.M Vaughan, Shyh-Jen Shih, Sheetal Singh, To Uyen Do
Journal: Cancer Research (2010)

Abstract Radiation and cytotoxic drugs exert much of their lethal effects by creating aberrations, such as dicentrics, that are lethal at a subsequent mitosis. Their accurate enumeration in experimental and clinical settings would provide valuable information on the efficacy of radiation and radiation/chemotherapy combinations. In this study a method was sought that could rapidly and efficiently quantitate this process using next generation sequencing. The use of modern molecular technology for aberration analysis has been restricted by the random nature of the breaks induced in individual chromosome that inhibit their detection. To overcome this problem, a common fragile site at 11q23 that is readily cleaved in response to a broad range of cytotoxic agents was used. Using irradiated human TK6 lymphoblastoid cells and blood samples taken from patients undergoing chemotherapy, partner chromosomes that are ligated to this location were detected using inverse PCR to capture the breakpoint. In order to enhance the efficiency of the process, amplified inverse PCR material was processed for Solexa type parallel sequencing. Here individual amplicons, representing the total content of a treated sample, are attached to a flow cell and their sequence recorded by sequential additions of fluorescent bases. Each aberration was then reconstructed with reference to a standard human genome database. In one specific sample of treated TK6 cells, two translocations involving Chr. 2 and 18 and two dicentrics involving Chr. 3 and 13 were found linked to the Chr 11q23 fragmentation site. In addition, aberrations were found in patients’ blood 6 months after initiation of therapy. Thus translocations that are rarely lethal could be readily discriminated from dicentric type rearrangements that are predominately lethal. The advantage of this analytical process is that all normal sequence is also recorded allowing the fractional content of all aberrations to be recorded in response to dose or time. In order to mitigate concerns over the arbitrary nature of aberrations induced at a common fragile site, a zinc finger nuclease was constructed targeting a region adjacent to the fragile site at 11q23. With this zinc finger system repetitive DNA breaks at the predicted site generated micro rearrangements (insertions/deletions) that were produced at far higher rates than translocations or dicentric type rearrangements measured by parallel processing. In summary, a novel analytical system for detecting a lethal class (dicentrics) of chromosome rearrangements has been described that is suitable for therapy monitoring both in-vitro and in-vivo. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3930.
Comparative detection of mite allergens in house dust of homes in Moscow by enzyme‐linked immunosorbent assay and acarologic analysis
Authors: T. M. Zheltikova, I. G. Ovsyannikova, V. B. Gervazieva, T. A. E. Platts‐Mills, M. D. Chapman, A. D. Petrova‐Nikitina, G. N. Stepanova
Journal: Allergy (1994)

The present study revealed that 73% of surveyed apartments in Moscow whose residents included children with the atopic form of bronchial asthma and sensitization to Dermatophagoides pteronyssinus allergens were infested with the pyroglyphid mites D. pteronyssinus and D. farinae. The number of mites in the surveyed apartments varied between 0 and 154 mites/g of dust for D. pteronyssinus and between 0 and 162 mites/g of dust for D. farinae. The levels of mite allergens in these apartments ranged from 0.5 to 165.8 micrograms/g for Der p I and from 0.3 to 91.3 micrograms/g of dust for Der f I. The Der p I allergen was found to predominate, and its concentration in one-third of the apartments was more than 10-fold greater than that of Der f I. Correlation between the number of pyroglyphid mites and the concentration of group I allergens was established for both D. pteronyssinus (r = 0.4932; P < 0.01) and D. farinae (r = 0.6748; P < 0.01). In most of the apartments, high and moderate levels of Der I allergens were detected.
A VALIDATED, PERIPHERAL BLOOD GENE EXPRESSION PATTERN CORRELATES WITH CORONARY ARTERIAL PLAQUE BURDEN BY QUANTITATIVE CORONARY ANGIOGRAPHY AND CORONARY ARTERY CALCIUM SCORING
Authors: Szilard Voros, Michael R. Elashoff, Amy J. Sehnert, Hsiao D. Lieu, James A. Wingrove, Susan E. Daniels, Steven Rosenberg, Alexandra Lansky, Robert S. Schwartz, William E. Kraus, Eric J. Topol
Journal: Journal of the American College of Cardiology (2011)
The prevalence of dental injuries in rugby players and their attitude to mouthguards.
Authors: R. M. Davies, D. Bradley, R. W. Hale, W. R. Laird, P. D. Thomas
Journal: British Journal of Sports Medicine (1977)

Although dental injuries may be considered relatively insignificant when compared to other forms of injury sustained by Rugby players (Weightman and Browne, 1974; Walkden, 1975) they can nevertheless cause considerable discomfort and necessitate the provision of otherwise unnecessary and expensive dental treatment. A certain number of-injuries are inevitable in contact sports, but as has been shown in a study of American footballers the risk of dental injury may be minimised by the wearing of mouthguards. Prior to 1962 dental injuries accounted for more than 25-30% of all injuries in American footballers. Since that time, the mandatory wearing of facemasks and mouthguards has prevented an estimated 100,000 oral injuries annually (Bureau of Dental Health Education Council on Dental Materials and Devices, 1973). The extent to which each of these devices contributed to this reduction in injury is not clear.
Fifty Hours for the Poor
Authors: Hilary Evans
Journal: JAMA (1990)

<h3>To the Editor.—</h3> I find it hard to believe that the average physician spends as<i>little</i>as 1 hour a week performing free services for those who can't afford to pay. It is insulting to the medical profession to suggest that this should be a standard and that medicine and law are equal in this regard.
85. Von Willebrand Factor (VWF) Gene Targeting by Double_Strand Break Enhanced Homologous Recombination
Authors: Nicole L. Prokopishyn, Brian R. Davis, Jonathan B. Rosenberg, Michael DiCola, Jennifer Brosius, R. Michael Blaese, Richard A. Metz
Journal: Molecular Therapy (2006)

Gene targeting by replacing the aberrant nucleotide sequence in the defective gene with the corresponding functional or |[ldquo]|normal|[rdquo]| sequence offers an idealized solution for treating genetic disorders. However therapeutic gene targeting has yet to be realized. Major advances have been made in gene targeting by utilizing site-directed DNA double strand break enhanced homologous recombination (DSB-GT). Most recently Urnov et al (2005) demonstrated DSBGT efficiencies approaching 20% in a gene, IL2R|[gamma]|, whose dysfunction can lead to human X-linked severe combined immune deficiency (X-SCID). This remarkable validation of DSB-GT technology utilized four fingered zinc-finger nucleases (ZFN) that recognized a unique endogenous sequence at a very high affinity.
Constructivism, nativism, and explanatory adequacy
Authors: Derek Bickerton
Journal: Behavioral and Brain Sciences (1997)

Constructivism is the most recent in a long line of failed attempts to discredit nativism. It seeks support from true (but irrelevant) facts, wastes its energy on straw men, and jumps logical gaps; but its greatest weakness lies in its failure to match nativism's explanation of a wide range of disparate phenomena, particularly in language acquisition.
Acute Effect of Glimepiride on Insulin-Stimulated Glucose Metabolism in Glucose-Tolerant Insulin-Resistant Offspring of Patients With Type 2 Diabetes
Authors: Dietrich Overkamp, Annette Volk, Elke Maerker, Peter E. Heide, Hans G. Wahl, Kristian Rett, Hans U. Häring
Journal: Diabetes Care (2002)

OBJECTIVE—This study addressed whether acute infusion of glimepiride influences glucose metabolism independent of its effect on insulin secretion. RESEARCH DESIGN AND METHODS—Ten healthy, glucose-tolerant but insulin-resistant probands were subjected to a placebo-controlled, double-blind, cross-over study. Each individual received infusions of either 0.15 mol/l saline or glimepiride in randomized order on two separate occasions. A three-step hyperinsulinemic (0.5, 1.0, and 1.5 mU · kg−1 · min−1)-euglycemic glucose clamp was performed on both occasions to determine insulin sensitivity. Glimepiride-induced insulin secretion was inhibited by octreotide. Endogenous glucose production and glucose elimination were measured with the “hot” glucose infusion method using U-[13C]glucose as tracer. Glucose oxidation was determined from indirect calorimetry. Lipolysis was evaluated by measurements of nonesterified fatty acid (NEFA) and glycerol concentration and measurement of glycerol production. RESULTS—Plasma glucose and insulin concentrations were not significantly different between glimepiride or saline infusions. There was a significant increase in the rate of glucose infusion necessary to maintain euglycemia during infusion of glimepiride during the low- (12.2 ± 1.1 vs. 16.1 ± 1.7 μmol · kg−1· min−1) and intermediate-dose insulin infusion (24.4 ± 1.7 vs. 30.0 ± 2.8 μmol · kg−1 · min−1). This was explained by an increased rate of glucose elimination and to a lesser degree by a decrease in glucose production. Glucose oxidation rate was not different. NEFA and glycerol concentration and glycerol production were equally suppressed. CONCLUSIONS—Glimepiride improves peripheral glucose uptake and decreases endogenous glucose production independent of its insulin secretagogue action. The effects shown in this acute study are, however, too small to be considered therapeutically beneficial for the individual patient.
Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor–related protein
Authors: Yasuhiro Suzuki, Nobuo Nagai, Kasumi Yamakawa, Junichi Kawakami, H. Roger Lijnen, Kazuo Umemura
Journal: Blood (2009)
Hirudin in Acute Myocardial Infarction
Authors: Elliott M. Antman
Journal: Circulation (1996)

The TIMI 9 trial evaluated whether the direct antithrombin hirudin is more effective than an indirect-acting antithrombin, heparin, as adjunctive therapy for thrombolysis in myocardial infarction.Patients (n = 3002) with acute myocardial infarction were treated with aspirin and either accelerated-dose tissue plasminogen activator (TPA) or streptokinase. They were randomized within 12 hours of symptoms to receive either intravenous heparin (5000 U bolus followed by infusion of 1000 U/h) or hirudin (0.1 mg/kg bolus followed by infusion of 0.1 mg/ kg per hour). The infusions of both antithrombins were titrated to a target activated partial thromboplastin time (aPTT) of 55 to 85 seconds and were administered for 96 hours. Patients randomized to hirudin were significantly more likely to have an aPTT measurement in the target range (P < .0001). The primary end point (death, recurrent nonfatal myocardial infarction, or development of severe congestive heart failure or cardiogenic shock by 30 days) occurred in 11.9% of the 1491 patients in the heparin group and 12.9% of the 1511 patients in the hirudin group (P = NS). Subgroup analyses did not reveal any profile of patients who benefited more from one of the antithrombins. The rate of major hemorrhage was similar in the heparin (5.3%) and hirudin (4.6%) groups; intracranial hemorrhage occurred in 0.9% of the heparin and 0.4% of the hirudin patients.Heparin and hirudin have an equal effect as adjunctive therapy to TPA and streptokinase in preventing unsatisfactory outcome in patients with acute myocardial infarction. Similar rates of major bleeding were observed for patients in the heparin and hirudin groups.
CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules
Authors: Stefanie Kliche, Tim Worbs, Xiaoqian Wang, Janine Degen, Irene Patzak, Bernhard Meineke, Mauro Togni, Markus Moser, Annegret Reinhold, Friedemann Kiefer, Christian Freund, Reinhold Förster, Burkhart Schraven
Journal: Blood (2011)
Long term use of lamotrigine and vigabatrin in severe refractory epilepsy: audit of outcome
Authors: M C Walker, L M Li, J W A S Sander
Journal: BMJ (1996)

The main point of this commentary, however, is to review the ethical decision to use chewing gum containing sucrose for the children in the control group.There are several reasons why an ethics committee based in the United Kingdom might have taken a different view from that reached in Finland.
The Leukotriene B4 Receptor (BLT1) is Required for Effector CD8+ T-Cell-Mediated, Mast Cell-Dependent Airway Hyperresponsiveness
Authors: N. Miyahara, C. Taube, V. Ott, B. Swanson, K. Takeda, S. Miyahara, S. Matsubara, T. Koya, J. Loader, L.D. Shultz, A.M. Tager, A.D. Luster, A. Dakhama, E.W. Gelfand
Journal: Journal of Allergy and Clinical Immunology (2006)
Radioisotope Scanning and Nuclear Medicine
Authors: JOSEPH F. ROSS
Journal: Annals of Internal Medicine (1965)

Editorials1 September 1965Radioisotope Scanning and Nuclear MedicineJOSEPH F. ROSS, M.D.JOSEPH F. ROSS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-3-538 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe development and perfection of radioisotope scanning, particularly photoscanning, and the invention of the "scintillation camera" (Schaer and Anger, page 442 in this issue of the ANNALS) have brought the youthful specialty of nuclear medicine to full maturity. Photoscanning provides information concerning the location, size, shape, function, and integrity of organs that can be provided in no other way, and makes possible easy localization of tumors, cysts, abscesses, infarcts, and abnormalities in blood flow that can be achieved with other techniques only with great difficulty or not at all.The unique diagnostic contributions that can be made by photoscanning, and...References1. CASSENCURTISREEDLIBBY BLCR: Instrumentation for I131 use in medical studies. Nucleonics 9: 46, 1951. Google Scholar2. MCAFEEFUEGER JGGF: Value and limitation of scintillation scanning in diagnosis of intracranial tumors, in Scintillation Scanning in Clinical Medicine, edited by QUINN, J. L., III, W. B. Saunders Co., Philadelphia, 1964, p. 215. Google Scholar3. WAXMANZIEGLERRUBIN HJDKS: Brain scans in diagnosis in cerebrovascular disease. JAMA 192: 453, 1965. CrossrefMedlineGoogle Scholar4. TAPLINJOHNSONDOREKAPLAN GVDEEH: Organ visualization by photo-scanning using micro- and macro-aggregates of radioalbumin, in Medical Radioisotope Scanning, Vol. II, International Atomic Energy Agency, Vienna, 1964, pp. 3-31. Google Scholar5. TAPLINPOE GVND: A dual lung scanning technique for evaluation of pulmonary function. Radiology August, 1965. CrossrefMedlineGoogle Scholar6. SODEE DB: Progress in medical radioisotope scanning pancreatography. J. Nucl. Med. 6: 356, 1965. Google Scholar7. JAFFEADAMSKROHN HLRL: Anteroposterior and lateral placental localization by Polaroid color scanning. Ibid., p. 364. Google Scholar8. GOTTSCHALKANGER AHO: Use of scintillation camera to reduce radioisotope scanning time. JAMA 192: 448, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: School of Medicine University of California Los Angeles PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1965Volume 63, Issue 3Page: 538-540KeywordsAbscessesBlood flowRadionuclide imaging Issue Published: 1 September 1965 PDF DownloadLoading ...