tbuckley/cabot-search huggingface dataset:
Everolimus (Afinitor®), Trastuzumab (H), and Paclitaxel (P) or Vinorelbine (V) in the Treatment of HER-2+ Metastatic Breast Cancer (MBC) Patients (Pts) Pre-Treated with Lapatinib-Containing Therapy: Pooled Analysis of 2 Phase I Studies.
Authors: F. Cardoso, V. Dieras, M. Campone, C. Massacesi, C. Manlius, P. Thevenaz, Y. Zhang, G. Jerusalem, T. Sahmoud, F. Andre, L. Gianni
Journal: Cancer Research (2009)

Abstract Introduction: The re-introduction of H-based therapy after progression on a lapatinib-containing regimen has not yet been supported by clear evidence. The aim of this analysis is to describe the safety and efficacy of the regimens everolimus (E) + H, and either P or V in patients pre-treated with lapatinib (L) in relation to those who did not receive previous L (N-L). Methods: Data from pts enrolled in two multicenter phase I studies (NCT00426556 and NTC00426530), with similar study design, were pooled and analyzed according to previous treatment with L. Regimens were: oral E daily (5 or 10mg) or weekly (20 or 30mg) + weekly H 2mg/kg IV, and either P 80mg/m2, IV D1-8-15 q4w (33 pts) or V 25 mg/m2, IV D1-8 q3w (46 pts). Results: Twenty-six (33%) of the overall 79 pts enrolled, received previous L (equally distributed among E dose cohorts). Baseline characteristics of the L and N-L groups, respectively, were: median age: 49 and 53 yo; visceral disease: 85% and 75% of pts; median number of previous chemotherapy lines for metastatic disease: 3 (range: 1-17) and 1 (range: 0-7); prior-taxanes and anthracyclines: 96% and 81% of the L pts, and in 96% and 85% of the N-L pts, respectively; 78 of 79 pts were H-resistant. The 26 pts pretreated with L were all resistant to L and had a median treatment duration of 24 wks (range: 6-123). In the L and N-L groups, the most frequently reported severe toxicities were G3/4 neutropenia in 58% and 75%, febrile neutropenia in 8% and 2%, G3 asthenia/fatigue in 19% and 13%, G3 stomatitis in 19% and 11%, G3 diarrhea in 4% and 6%, respectively. G1/2 rash was reported in 15% and 34% of L and N-L pts, respectively. Mean left ventricular ejection fraction was similar at baseline and at end of treatment (EOT) in L and N-L pts: 63% (+/- 7%) in both groups at baseline, and 60% (+/- 7%) and 64% (+/- 6%) at EOT, respectively. Table 1 summarizes the efficacy observed in the 74 evaluable pts to date. Time to progression (TTP) appears longer in the N-L group and may be a result of less pre-treatment in this group. Conclusions: In our experience patients pre-treated with lapatinib are not at a higher risk of toxicity and do not seem to have a substantially different outcome when re-treated with trastuzumab-containing regimens in combination with everolimus.Table 1. Overall response and time to progression (Kaplan-Meier based) Lapatinib-pretreated (n=25)Not Lapatinib-pretreated (n=49)Best Response, n (%) CR–3 (6)PR5 (20)12 (25)SD16 (64)27 (55)PD4 (16)7 (14)TTP, median (weeks)29 (21-41)38 (29-44)CR, complete response; PD, progressive disease; PR, partial response; SD, stable disease; TTP, time to progression. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5064.
ELITE SOCCER'S LOWER LIMBS EXPLOSIVE STRENGTH ASYMMETRY
Authors: Frantisek Zahalka, Tomas Maly, Lucia Mala, Jaroslav Teplan, Tomas Gryc, Eva Vaidova, Mikulas Hank, Mario Buzek
Journal: British Journal of Sports Medicine (2013)

Background A vertical jump is one of essential motor skills in many sports (Vanezis &amp; Lees, 2005). Monitoring and description of vertical jumps is based on both external movement structure and explosive strength of lower limbs as a basic driving impulse for its performance. Explosive strength is one of the most important components for the body increasing and vertical jump (Aragon, 2000). Methods The research group consisted of elite soccer players (n=138, age=25,1±4,7 years, height=184,2±7,2 cm, weight=79,7±8,1 kg). For recording force effect of lower limbs on the surface, two force platforms Kistler B8611A (KISTLER Instrumente AG, Switzerland) were used. All participants performed three types of a vertical jump, T1–countermovement jump with arms included, T2–countermovement jump with arms excluded, T3–squat jump. Evaluation parameters were: high of the jump (cm), maximal strength produced by separate lower limb FmaxR(L) and strength impulse produced by separate lower limb during the take off (Ns-1). Results The heights of the jumps were CMJ-FA=42.83±4.88 cm, CMJ=37.55±4.18 cm a SQJ=35.97±3.97cm. Maximal strength produced by separate lower limb was recalculated by dividing to weight of every player as a strength for one kilogram; FmaxPT1=1.32±0.11 N.kg-1 resp. FmaxLT1=1.27±0.11 N.kg-1; FmaxPT2=1.33±0.14 N.kg-1 resp. FmaxPT2=1.28±0.16 N.kg-1; FmaxPT3=1.12±0.12 N.kg-1 resp. FmaxLT3= 1.09±0.09 N.kg-1. The level of asymmetry was evaluated by percentage difference between maximal strength of right or left lower limb per one kilogram of boy weight. Percentage difference between maximal strength was T1=5.86±4.58%; T2=9.61±7.92, T3=5.47±6.49%. Evaluation of lower limbs asymmetry by help of strength impulse using the take off was T1=9.91±10.49 N.s-1, T2=8.55±7.34 N.s-1, T3=5.69±4.73 N.s-1. Discussion/Conclusions The best results were achieved in the first type of the vertical jump (T1). Results of the countermovement jump without arm swing (T2) and squat jump without arm swing (T3) are more comparable, although it could be expected that squat position could improve the height of absolute value of the vertical jump. The biggest asymmetry by maximal strength point of view was found in the jump T2. Jumps T1 and T2 had asymmetry by maximal strength point on were similar and the absolute value was only half according to jump T1 asymmetry. The biggest asymmetry by strength impulse was in the jump T1, rest jump's aszmmetry were lower (T2-13%; T3-42%). Project was supported: MSM 0021620864, GACR P407/11/P784, PRVOUK 38.
Experimental evidence that the physiological position of the liver within the circulation is not a major determinant of zonation of gene expression
Authors: Gerry T. M. Wagenaar, Robert A. F. M. Chamuleau, Jan G. de Haan, Martinus A. W. Maas, Piet A. J. de Boer, Frans Marx, Antoon F. M. Moorman, Wilma M. Frederiks, Wouter H. Lamers
Journal: Hepatology (1993)

Many enzymes are distributed heterogeneously within the liver lobule. The factors that play a determining role in the establishment and maintenance of these heterogeneous expression patterns have not yet been identified. To investigate whether the composition of the afferent hepatic blood plays a crucial role in the maintenance of the heterogeneity of gene expression of the parenchymal cells within the liver lobule, we changed the source of the afferent hepatic blood by microsurgical techniques. Three different groups of experimental animals were studied: rats with livers that are perfused with portal blood only (ligation of the hepatic artery), with caval blood only (portocaval transposition and ligation of the hepatic artery) and arterial blood only (portocaval shunt, arterialization of the distal end of the portal vein and ligation of the hepatic artery). To study differences in gene expression patterns, we chose enzymes that have a heterogeneous expression pattern within the liver lobule: the periportally located enzymes carbamoylphosphate synthase, succinate dehydrogenase, phosphoenolpyruvate carboxykinase and the pericentrally located enzymes glutamine synthase, glutamate dehydrogenase and NADPH-cytochrome P-450 reductase. To eliminate the potential interference of the long half-lives of some of these proteins on the interpretation of the results, we also studied the distribution of the mRNAs of carbamoylphosphate synthase, glutamine synthase, glutamate dehydrogenase and phosphoenolpyruvate carboxykinase. The animals were studied 2 wk after the operations. On the basis of their changes in body weight the animals were in steady state for at least a week. The patterns of gene expression of the enzymes studied did not change, regardless of the source of the altered afferent hepatic blood. The changes in gene expression that were observed in animals that did not regain their preoperative weight were shown to be caused by a limited intake of food. This study demonstrates that the physiological position of the liver within the circulation (i.e., between the gastrointestinal tract and the systemic circulation) is not as critical as is often stated and is certainly not essential for the maintenance of liver cell heterogeneity. The data suggest that the direction of the bloodstream (i.e., the existence of an upstream and a downstream compartment) is a major determinant of zonation of gene expression.
Inhibition of hormone-stimulated lipolysis by clofibrate. A possible mechanism for its hypolipidemic action.
Authors: M A D'Costa, A Angel
Journal: Journal of Clinical Investigation (1975)

The present study was undertaken to investigate the mechanism of the antilipolytic action of clofibrate (p-chlorophenoxyisobutyrate). Clofibrate, in the dose range of 10-80 mg/199 ml, inhibited the initial rate of norepinephrine-stimulated lipolysis 17-44 percent in isolated rat fat cells. At a dose corresponding to therapeutic levels in vivo (10 mg/100 ml) clofibrate also inhibited hormone-stimulated lipolysis by 20-30 percent in fragments of human subcutaneous fat. Inhibition of lipolysis by clofibrate occurred at all concentrations of norepinephrine and ACTH (0.02-0.1 mug/ml) but did not occur with equilipolytic concentrations of dibutyryl cyclic AMP, suggesting a proximal site of action on the lipolytic sequence. Clofibrate reduced by 60 percent (315plus or minus40 vs. 120plus or minus25 pmol/g lipid; meanplus or minusSEM) the norepinephrine-stimulated initial rise in cyclic AMP, measured 10 min after addition of hormone. Because the antilipolytic effect occurred in the presence of glucose and without altering cellular ATP levels, the reduction in intracellular cyclic AMP levels could not be attributed to uncoupling of oxidative metabolism or to secondary effects of free fatty acid accumulation. In the secondary effects of free fatty acid accumulation. In the presence of procaine-HC1, which blocks hormone-stimulated lipolysis without inhibiting cyclic AMP accumulation, addition of clofibrate prevented the hormone-stimulated rise in cyclic AMP. Clofibrate did not affect the activity of the low-Km 3',5'-cyclic AMP phosphodiesterase in norepinephrine-stimulated adipocytes. These data suggest that the antilipolytic effect of clofibrate is due to its suppression of cyclic AMP production by inhibition of adenylate cyclase. The drug's hypolipidemic action may in part be explained by its antilipolytic effect, which deprives the liver of free fatty acid substrate for lipoprotein synthesis.
Bronchodilator Aerosol
Authors: Timothy H. Smelzer
Journal: JAMA (1973)

A simple hand-held device was altered to provide isoproterenol hydrochloride via either powered nebulization or intermittent positive pressure breathing (IPPB). Sixteen patients with stable chronic obstructive airway disease were studied in a random alternate sequence on two successive days. Approximately 0.8 ml of 1:400 solution of isoproterenol hydrochloride was delivered to the patient each time either method was used. Ventilatory dynamics and arterial blood gases were measured before and after each use of the device. Sequential changes in forced vital capacity and forced expiratory volume in one second were remarkably similar no matter which method was used. No conclusions could be drawn from the changes in arterial pH and gas pressures. Based on functional improvement in patients with stable chronic obstructive airway disease, the therapeutic benefit from isoproterenol administered by IPPB was not significantly different from that observed after otherwise identical treatment with a simple powered nebulizer.
ROUX–EN–Y GASTRIC BYPASS IMPROVES OBESITY–INDUCED ENDOTHELIAL DYSFUNCTION BY A GLUCAGON LIKE PEPTIDE–1 MEDIATED BODY WEIGHT LOSS INDEPENDENT EFFECT
Authors: Elena Osto, Caroline Corteville, Kerstin Spliethoff, Marco Bueter, Christian Matter, Thomas Lutz, Thomas F. Luscher
Journal: Journal of the American College of Cardiology (2013)
Antitrust Guidelines in Health Care Markets
Authors: Joe Miller
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
13N-NH3 Versus F-18 FDG in Detection of Intracranial Meningioma
Authors: Zhang Xiangsong, Shi Xingchong, Yi Chang, Wang Xiaoyan, Chen Zhifeng
Journal: Clinical Nuclear Medicine (2011)

Relatively high Tl-201 uptakes have been reported in all types of meningiomas, and it have been proposed that (201)TlCl SPECT could predict histologic types of meningiomas and differentiate the benign and aggressive meningiomas. Similar to Tl-201, (13)N-(13)NH(4)(+) is an analog of K(+) and could substitute K(+) in some cases. The aim of this study was to evaluate the capacity of PET with (13)N-NH(3) to discriminate meningioma from healthy tissue, and compare with F-18 FDG.Eleven patients with the neuroradiologic diagnosis of meningiomas were studied with (13)N-NH(3), and 10 of them were performed with F-18 FDG PET within 3 days. Ten of them were histologically confirmed (6 grade I, 4 grade II), and another one was proved by radiologic (computed tomography and magnetic resonance imaging) and clinical investigation.The PET images were evaluated by semiquantitative analysis using tumor-to-white matter ratio (T/W).(13)N-NH(3) uptake was obviously increased in all 11 meningiomas with a good contrast to the surrounding normal brain tissues. Conversely, F-18 FDG uptake was decreased in comparison with the contralateral side in all 7 patients with grade I meningiomas and moderately increased in the remaining patient with grade II meningioma. The T/W ratio of (13)N-NH(3) was higher than that of F-18 FDG (7.03 ± 1.62 vs. 1.44 ± 0.57, P < 0.005). T/W of (13)N-NH(3) uptake was not useful for differentiating benign (Grade I) from atypical (Grade II) meningiomas (P = 0.88), whereas the T/W ratio of F-18 FDG uptake was better than that of N-NH3 for differentiating benign from malignant meningiomas (P = 0.037).These preliminary results suggest that (13)N-NH(3) has relatively greater uptake in meningiomas in comparison with F-18 FDG. Clinical applications of (13)N-NH(3) PET for grading and follow-up of meningiomas need to be assessed in further studies.
The clinical potential of ARGX-111, an afucosylated anti-MET antibody, in hematological malignancies and suppression of metastasis
Authors: V. Hanssens, N. De Jonge, A. Hultberg, C. Borg, P. Michieli, T. Dreier, H. de Haard, A. Thibault
Journal: Annals of Oncology (2015)
Teleconferencing should be extended to include job interviews
Authors: G. Briars
Journal: BMJ (1997)

Gulf war illness Why it took so long to decide to investigateEditor-As it is now six years since the Gulf war, it is reasonable to ask why the problem of Gulf war syndrome has not been resolved. 1 As surgeon general in 1991-4 I want to comment on the unravelling timetable during these six years.At no time have we denied that Gulf veterans have been ill-indeed, whenever possible we have actively recommended their appropriate medical management.Secondly, despite press reports, we have always kept an open mind on the presence of a specific Gulf war syndrome.The Gulf conflict in 1990-1 itself was short, casualties mercifully few, and the sickness rates unremarkable; likewise, when troops returned to the UK the daily sickness rate did not increase.Also at that stage little evidence existed of psychiatric illness or post-traumatic stress syndrome.Some 18 to 24 months later, however, we became aware of a campaign by lawyers to recognise a specific Gulf illness.Up to 200 people were on their books, but despite widespread appeals for them to come forward, including two television appeals, only 15 approached the armed forces medical services.Not surprisingly, among these 15 no pattern of illness emerged.They were all managed appropriately.As we were keen to solve the problem, in October 1993 we appointed a single consultant physician, Group Captain Coker, to see all such patients.At first only a trickle of patients came forward-even by June 1994 (three and half years later) he had seen only 30 patients.Over the next two years, however, these numbers increased so that by January 1997, 1100 had been registered, 920 had been seen and fully investigated, and results had been completed and analysed in 519.A preliminary paper in the summer of 1996 concluded: "From our small database it would not appear that there is a unique cluster of symptoms which would suggest a new pattern of illness in veterans." 2 There was, however, a higher than normal incidence of psychiatric and stress related illness.A large battery of tests was uniformly performed on all the patients, with further investigations as necessary.Now it has been agreed that full epidemiological studies are to be undertaken into the incidence of ill health among UK Gulf war veterans and into their reproductive health.In answering the criticism that these expensive studies should have been instigated earlier, I have tried to show how difficult it has been to decide exactly when this decision could have been made.Early on there were very few patients and no evidence of a syndrome.At all stages we have liaised with our counterparts in the United States.They embarked a little earlier on similar studies as they had similar results to their investigations but dealt with greater numbers.An important reason for writing this letter is because our armed forces may well be placed in similar alien environments in future and we owe it to them to provide the best medical support, which of course includes planned protective and scientifically justified measures against likely threats to their health.
Improving the Electronic Health Record—Are Clinicians Getting What They Wished For?
Authors: James J. Cimino
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Veterans Administration Medical Care System Faces an Uncertain Future
Authors: John K. Iglehart
Journal: New England Journal of Medicine (1985)

The vast medical care system that serves the nation's military veterans faces an uncertain future that is framed by the humanitarian instincts of society, a conservative administration that seeks to decrease public spending, a population of veterans that is rapidly aging, and a private health sector that may have more hospital beds and physicians that it can efficiently deploy in the future. This complex set of forces is emerging in a chaotic fashion that makes it difficult for the federal government to plan for, much less control, the future in relation to the medical care program of the Veterans Administration . . .
1022-79 Is early prehospital administration of abciximab superior to periprocedural therapy in patients with ST-segment elevation myocardial infarction and planned percutaneous coronary intervention? Early and late results from the randomized REOMOBILE pilot study
Authors: Hans-Richard Arntz, Joachim Schröder, Klaus Pels, Bernhard Witzenbichler, Peter Schwimmbeck, Dirk Müller, Schultheiss Heinz-Peter
Journal: Journal of the American College of Cardiology (2004)
Case-Control Study of IDDM
Authors: Jack Siemiatycki, Eleanor Colle, Sally Campbell, Ron A D Dewar, Mimi M Belmonte
Journal: Diabetes Care (1989)

Insulin-dependent diabetes mellitus (IDDM) may be caused by a combination of genetic predisposition and environmental insults. However, there are few solid leads concerning human diabetogenic environmental agents. A case-control study was carried out to investigate the possible relationships between IDDM and various biological, chemical, and psychological factors. All 161 cases of IDDM among children aged 0–17 yr occurring in Montreal from 1983 to 1986 were included. The parent of each newly diagnosed diabetic subject was asked to provide the names of two of the child's friends or neighbors who would be age and sex matched to serve as controls. For those unable to do so, matched controls were selected from a hospital emergency room. Parents of cases and controls were interviewed concerning many factors. There was little or no difference between cases and controls with regard to parental smoking habits, exposure to pets, and consumption of meat products high in nitrosamines. In univariate analyses, there was some indication of elevated risk for children who had not been breast-fed, who attended day care or nursery before age 5 yr, who lived in a crowded household at age 3 yr, or who had a history of asthma or eczema, although in multivariate analyses the only variables that had any effect were crowding and day-care attendance. In univariate and multivariate analyses, there was high risk of IDDM among children who had experienced selected stressful life events during the 12 mo preceding onset of IDDM or who had exhibited symptoms of social or psychological dysfunction during that time. Some of these apparent effects may have been due, in part, to biases induced by the method of selecting controls and to the interview process.