tbuckley/cabot-search huggingface dataset:
A light at the end of the tunnel
Authors: S G BOWN
Journal: Gut (1998)

See article on page747 

The article by van Laethem et al in this issue (see page 747) describes a well conducted study using the argon plasma coagulator (APC) to treat Barrett’s oesophagus in 31 patients. However, complete eradication of Barrett’s mucosa was only confirmed histologically in 19 (61%), the remainder having a few residual Barrett’s glands under the new squamous epithelium. Seventeen of those with apparent complete endoscopic and histological eradication at early follow up were biopsied again a year later, eight (47%) of whom had relapsing islands of Barrett’s metaplasia despite continuous treatment with omeprazole. These results lead to the same conclusion as that emerging from many recent studies on the endoscopic treatment of Barrett’s oesophagus using a variety of techniques.1-5It is possible to destroy specialised columnar epithelium in the oesophagus with a range of techniques and the treated areas heal with regeneration of squamous epithelium. However, there is a high risk of leaving some Barrett’s glands under the regenerated squamous epithelium. This raises two crucial questions. Firstly, does it matter if a few glands are left behind and, secondly, can any of the treatment options be modified to give reliable destruction of all the Barrett’s glands without any unacceptable complications.

The first question is tackled in the paper, although is very difficult to answer. Statistically, if …
Pure Penicillin in Ophthalmology
Authors: A. Sorsby, J. Ungar
Journal: BMJ (1946)

Case 6.-Para-2, aged 26.28/4/46: Normal delivery.Breast- feeding begun.Owing to shortage of beds this patient was transferred to the district on the third day of the puerperium.She herself attempted to discontinue breast-feeding on the tenth day and developed acute puerperal mastitis.12/5/46: Readmitted to hospital.T. 1000 F. (37.80 C.); P. 106.Tender flushed left breast.Thickened area 2 in.(5 cm.) in diameter in upper and outer quadrant.Penicillin started.Baby put back on breast and all artificial feeding stopped.13/5/46: T. 1000 F. (37.80 C.); P. 104.Breast flush limited to upper and outer quadrant.Tenderness also limited to this area.14/5/46: T. 1000 F. (37.80 C.); P. 88. Thickening now 1 in.(2.5 cm.) in diameter.Slight flush.Slight tenderness.15/5/46: T. 97.80 F. (36;550 C.); P. 64.No flush.Slight thicken- ing.16/5/46: T. 980 F. (36.70 C.); P. 80.No thickening, flush, or tenderness.Penicillin discontinued.Total dosage,-500,000 Oxford units.Two weeks later this patient returned to the clinic.She was still lactating freely, but the baby was again being artificially fed.She was instructed to re-establish breast-feeding, but has since refused to return to clinic.
The effect of hyaluronan-based delivery of stromal cell-derived factor-1 on the recruitment of MSCs in degenerating intervertebral discs
Authors: Catarina Leite Pereira, Raquel M. Gonçalves, Marianna Peroglio, Girish Pattappa, Matteo D'Este, David Eglin, Mário A. Barbosa, Mauro Alini, Sibylle Grad
Journal: Biomaterials (2014)
Abstract 1566: Effects of VEGFR-3 phosphorylation inhibitor on lymph node metastasis in diffuse-type gastric carcinoma
Authors: Masakazu Yashiro, Osamu Shinto, Yukihiro Kato, Shinichiro Kashiwagi, Yuhiko Fuyuhiro, Junko Matsuoka, Yosuke Doi, Satoru Noda, Junya Morimoto, Sadaaki Yamazoe, Tasuku Matsuoka, Hiroaki Tanaka, Masaichi Ohira, Tetsuji Sawada, Kosei Hirakawa
Journal: Cancer Research (2010)

Abstract Background: Vascular endothelial growth factor receptor-3 (VEGFR-3) signaling mediates lymphangiogenesis and lymphatic invasion, however the effect of VEGFR-3 inhibition on the lymph node (LN) metastasis remains unclear. The aim of this study is to clarify the benefit of a VEGFR-3 inhibitor Ki23057 for LN metastasis. Methods: Ki23057 was administered orally to gastric cancer models created by orthotopic inoculation of diffuse-type gastric cancer cells, OCUM-2MLN. Effects of Ki23057 on lymphatic vessel invasion, lymphatic vessel density, and VEGFR-3 phosphorylation were examined by immunostaining or immunoblotting. Results: Ki23057 inhibited the autophosphorylation of VEGFR-3 with IC50 values of 4.3 nM in the cell-free kinase assay. Murine gastric cancer models created by the orthotopic inoculation of OCUM-2MLN cells showed the diffusely infiltrating growth and frequently developed LN metastasis. The oral administration of Ki23057 significantly (p&amp;lt;0.01) reduced the size of orthotopic tumors and the number of the metastatic LN in gastric cancer models. The degree of lymphatic invasion and lymphangiogenesis was significantly (p&amp;lt;0.05) lower in the gastric tumors treated by Ki23057. Ki23057 inhibited the phosphorylation of VEGFR-3 of lymphatic endothelial cells in gastric tumors. Conclusion: The inhibition of lymphangiogenesis targeting VEGFR-3 phosphorylation is a therapeutic strategy for inhibiting LN metastasis of diffuse-type gastric cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1566.
ECHOCARDIOGRAPHIC EVALUATION HAS A LOW SENSITIVITY FOR DETECTION OF PATIENTS WITH ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY (ARVC) USING THE GUIDELINES CRITERIA OF 2010
Authors: Pyotr Platonov, Rasmus Borgquist, Thomas Gilljam, Kristina Haugaa, Thor Edvardsen, Henning Bundgaard, Anders G. Holst, Jim Hansen, Ole Eschen, Jesper Svendsen, Arrhythmia Clinic
Journal: Journal of the American College of Cardiology (2013)
Watching Gallstones Form
Authors: Rebecca Voelker
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Points: Portrait of a social reformer
Authors: R H. Parry
Journal: BMJ (1983)

December, p 1617) of a patient in whom atenolol treatment apparently precipitated renal artery thrombosis.Recent reports suggest that the angiotensin converting enzyme inhibitor captopril may cause the same complication in patients with pre-existing renal artery stenosis.Oelkers' has described two patients with renovascular hypertension who developed renal artery occlusion during treatment with captopril, and, according to Hollenberg,' about 10% of patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney developed rapidly progressive renal failure during the first few weeks of treatment with captopril.Half of these patients recovered renal function with a reduction in dosage of captopril.No details of the remaining patients were given, but one might speculate that some or all of them may also have developed renal artery thrombosis.
CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development
Authors: Brenda A. Finney, Edina Schweighoffer, Leyre Navarro-Núñez, Cecile Bénézech, Francesca Barone, Craig E. Hughes, Stacey A. Langan, Kate L. Lowe, Alice Y. Pollitt, Diego Mourao-Sa, Steve Sheardown, Gerard B. Nash, Nicholas Smithers, Caetano Reis e Sousa, Victor L. J. Tybulewicz, Steve P. Watson
Journal: Blood (2011)
Obesity as a Depressive Equivalent
Authors: Robert I. Simon
Journal: JAMA (1963)

THE CURRENT United States Air Force Weight Control Program affords an opportunity to study some specific points concerning obesity. The hypothesis is advanced that obesity is a depressive equivalent, that is, it is believed that certain individuals ward off and allay depressive feelings by increasing the amount and frequency of their food consumption. The purpose of this paper is to report a test of this hypothesis by standard statistical methods and to discuss the relevant psychologic and management problems of the obese. Since obesity is thought to be the direct result of overeating to assuage depression, it was anticipated that one would find the incidence of overt depression to be considerably lower in people utilizing this mechanism, namely, in overweight persons. Overweight is defined from the standard scaled age-weight tables of the United States Air Force (AFM 160-1). Twenty-seven overweight officers and airmen and 50 randomly selected nonobese personnel without
Treatment of the Patient after Myocardial Infarction
Authors: Eugene Braunwald
Journal: New England Journal of Medicine (1980)

At the turn of the decade, the results of three major clinical trials concerned with the treatment of patients who have survived an acute myocardial infarction are being published. One of these, on the use of sulfinpyrazone, appears in this issue of the Journal. Two similar investigations of the use of aspirin are being presented almost simultaneously.1 , 2 When one considers the enormous number of post-infarction patients, the findings of these studies — indeed, of the vast body of information that has been amassed in recent years concerning treatment of these patients — deserve the most careful scrutiny.For convenience, let . . .
Lovastatin vs Cholestyramine Therapy for Primary Hypercholesterolemia
Authors: Mark R. Goldstein
Journal: JAMA (1988)

<h3>To the Editor.—</h3> A multicenter study<sup>1</sup>published in the July 15 issue of<i>JAMA</i>compared lovastatin and cholestyramine resin for treating severe primary hypercholesterolemia and concluded that lovastatin was both more effective and better tolerated. There is no argument that lovastatin is better tolerated than cholestyramine; however, I am not convinced that it is more effective. The Lipid Research Clinics Coronary Primary Prevention Trial<sup>2</sup>and the more recently published Helsinki Heart Study<sup>3</sup>—both long-duration primary prevention trials—demonstrated that coronary heart disease morbidity and mortality can be reduced by favorably altering lipoprotein levels using cholestyramine in the former and gemfibrozil in the latter trial. Unfortunately, neither trial resulted in a decrease in overall mortality in the groups receiving drug treatment. Fifteen-year follow-up of a secondary prevention trial<sup>4</sup>did reveal a decrease in coronary heart disease mortality and overall mortality in the niacin-treated group. Cholestyramine, gemfibrozil, and niacin
Effect of polymer coating on faecal recovery of ingested 5-amino salicylic acid in patients with ulcerative colitis
Authors: I. Bjarnason, K. Middleton
Journal: Gut (1988)

Very little is known about the normal temporal and quantitative relationships between gastric emptying and gall bladder emptying. Using a non-invasive double isotope technique these relationships were investigated in 22 normal healthy adults. 99Tcm EHIDA was used as the biliary tracer and 113Inm labelled bran as the gastric content tracer. Gastric emptying was monoexponential with a t1/2 of 45 +/- 3 minutes (mean +/- SEM). In 15 subjects the gall bladder emptied in relation to eating according to a double exponential function. In these subjects 15.0 +/- 1.6% of gall bladder contents emptied before gastric emptying began. They could be further divided into two clear cut types (p less than 0.001), according to the ejection fraction at 10 minutes and the t1/2 of the first exponential. Emptying of the gall bladder was faster and more of its contents were ejected in subjects with a type I response (n = 9) than in subjects with a type II response (n = 6). In the remaining seven subjects the gall bladder began to empty spontaneously, unrelated to eating. These observations suggest that gall bladder emptying: (a) may have a cephalic phase, (b) can be expressed as a double exponential function, (c) may occur unrelated to eating, (d) which occurs only in relation to eating would appear to be either fast (type I) or slow (type II).
"DECEREBRATE RIGIDITY" IN MAN
Authors: J. S. Manson, F. R. Ferguson
Journal: BMJ (1930)

DECEREBRATh RIGIDITY" I MAN.EDICA Jori 769 iieiit of dosage intensities-by Lee an4 Pack, following, the p-,lain emplo-yed by Maitiln and(. (Qinimby in their dosage intensityt calkulations forr intra,oia I cancer, suggests the iced for greater relative intenisities .inbreast cancel than ill monltlh cancer.Tlhev hiave, de*monstrateA at the same tim ae that these required doses of intensities, nell beryond ten er-vtlheinias, can be carried througli practically.Their inlimlulmi standlards of in-tensitv lbare niot vet been deter- minie(l, and it mlay be fouind' that a ver-y con-siderable pereentage of the cases responid to a mnuch lower relative (auantity of irradiation.II tihe lymphatic, glaiiultilar, neoplastic, anid pseudo- malignant diseases-lymiphosarFconma, Hodgkini's disease, and leukaoinia-radium miay be useful, anid is occasionalf of real v-alne for some specific reasoln.In genieral, hawever, tlhe w-idlespread character of tlhe involvement leaids itself be.st to treatment bv x-radiation.The treatm-nent is palliative onlv.The bo)ie tiuiiouir pr'oblem is as dis-couraging as it is Iascii,atiHig.Radiationi has-imlade butt two distinct contri- lhtionos, attributable alike to eitlhel-x riavs or radiumiii, or both.Giant-cell tumours of bone are curable by externial irradiation.The peculiar responise of endothelial my-elomla of bonie to radiation led originally to its recognitionl as a definite clinical entity, and irradiati&ni has remaiined the treatmenit of choice.The tendelncy to early and widesp.readdissemination of this growth, how-ever, rleniders cure extrenmelv doutbtfil.The trule osteo,genic t ours of bone are extremelv radio-resistant, and radium has done nothin more than afford a moderate deogree of palliative relief and growi-thi restraint.Sum nm nary. 1. Radiunm has made a notable contribution and has added stiulltus to the general problem of cancer investigation.2. Since it is an agent for local application only, it must not be regarded as an ideal cancer cutre.3. It lhas, however, increased the curability of cancer. 4. It hias redticed the limits anid the severity of many oJ)erative suirgical procedures.5. It has supplanted some surgical operations entirely.6.It has relieved operative surgery of the responsibility for attempting the unreasonable or impossible, as a frantic effort, in a large and varied grouLp of cases.7. It has made possible a larger measulre of palliative relief in advanced cancer. 8. Advancement in radiuim ther-apy depends upon the intensive co-operation of pathologist, cliniciani, and physicist.9. The technical problems of application and dosage intenisit-must be calcuilated and malde with the greatest possible care and precision.10.The combinationi of radium emanation, x-radiation, and olperative suirgery offers far more iii the average case of cancer than adherence to any one agent alone: they are complementary, and not competitive.
Exercise Triggers ARVC Phenotype in Mice Expressing a Disease-Causing Mutated Version of Human Plakophilin-2
Authors: Francisco M. Cruz, David Sanz-Rosa, Marta Roche-Molina, Jaime García-Prieto, José M. García-Ruiz, Gonzalo Pizarro, Luis J. Jiménez-Borreguero, Miguel Torres, Antonio Bernad, Jesús Ruíz-Cabello, Valentín Fuster, Borja Ibáñez, Juan A. Bernal
Journal: Journal of the American College of Cardiology (2015)
Regulation of myosin heavy chain genes in the heart.
Authors: E Morkin
Journal: Circulation (1993)

Advances in our knowledge of the regulation of cardiac myosin isoforms made possible by molecular cloning of the alpha- and beta-MHCs genes are reviewed. Expression of these genes in heart does not seem to require MyoD or related proteins of the skeletal muscle myogenic program. Cardiac MHC genes are under the control of T3, which stimulates transcription of the alpha-MHC gene and inhibits beta-MHC mRNA production both in vivo and in cultured heart cells. The responsiveness of the genes to T3 varies in different mammals, however. The genes are most responsive in rat and rabbit, intermediate in sensitivity in calf and subhuman primate (baboon), and very resistant in the dog. The human alpha-MHC gene is T3-inducible in ventricle, but the degree of response has not been quantified. Introduction of chimeric plasmids containing 5' flanking sequences of cardiac MHC genes fused to the CAT gene into cultured heart cells and transgenic animals has permitted identification of regulatory elements. Although the genes are closely linked in genomic DNA, they are controlled independently. The element within the alpha-MHC promoter responsible for induction by T3 is located approximately 160 base pairs from the transcription initiation site. Additional transcriptional activators located 5' upstream amplify the response to T3, probably by looping out intervening DNA sequences. The proximal region of the beta-MHC gene contains important regulatory elements, including those required for repression by T3, muscle-specific expression, a MyoD-independent positive element, and a hormone-independent repressor.(ABSTRACT TRUNCATED AT 250 WORDS)
Primary biliary cirrhosis: Associations with class II major histocompatibility complex antigens
Authors: Gregory J. Gores, Breanndan S. Moore, Lloyd D. Fisher, Frank C. Powell, Rolland E. Dickson
Journal: Hepatology (1987)

Tissue injury in primary biliary cirrhosis is thought to be mediated by immune mechanisms. Various Class II antigens of the major histocompatibility complex are associated with autoimmune diseases and their differing clinical manifestations. Thus, the aim of this study was to examine the relationship between primary biliary cirrhosis, its clinical manifestations and serologically defined Class II antigens (HLA-DR and HLA-DQ). Typing for these antigens was performed in 114 primary biliary cirrhotic patients and 171 controls by lymphocytotoxicity. There was a 6-fold increase in the frequency of HLA-DRw8 in primary biliary cirrhosis as compared to controls [30.1 vs. 4.7% (p &lt; 0.0001)]. In contrast, HLA-DR5 had a decreased frequency in primary biliary cirrhosis as compared to controls [9.8 vs. 25.2% (p &lt; 0.02)]. We examined the relationship between Class II antigens and the following prognostic indicators in primary biliary cirrhosis: serum bilirubin; 24-hr urine copper; serum albumin; prothrombin time; platelet count; ascites, and histologic stage (I to IV). Patients who are positive for HLA-DRw52 (n = 82) had a 2-fold increase in serum bilirubin compared to those who are negative (n = 32) for this antigen (p &lt; 0.05). Conversely, patients who are positive for HLA-DR2 had less than half the serum bilirubin values of those negative for this antigen (p &lt; 0.02). In conclusion, we found different Class II antigens to be associated with a prognostic indicator in primary biliary cirrhosis (serum bilirubin), while HLA-DRw8 is strongly associated with the disease itself. These data suggest that determining Class II antigens may be important in predicting the course and clinical expression of primary biliary cirrhosis.
Comments and Critiques on the EMBRACE Health Care Reform Plan
Authors: Richard L. O'Brien, Donald Frey
Journal: Annals of Internal Medicine (2009)

Letters3 November 2009Comments and Critiques on the EMBRACE Health Care Reform PlanRichard L. O'Brien, MD and Donald Frey, MDRichard L. O'Brien, MDFrom Creighton University, Omaha, NE 68178.Search for more papers by this author and Donald Frey, MDFrom Creighton University, Omaha, NE 68178.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-9-200911030-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Regarding the proposal by Lancaster and colleagues (1), what tier would persons with chronic, debilitating, but not life-threatening, diseases fit into? Consider persons with rheumatoid arthritis or those with developmental disabilities who also have mental illness. Treatment for these persons clearly falls into the category of “quality of life” and maintenance of function.It therefore seems that such persons would fall into Tier 2. If so, and if persons with such conditions cannot afford private insurance premiums, will they simply suffer “functional impairment,” pain, and disability? Will they qualify for Tier 1 only after their condition deteriorates ...Reference1. Lancaster GI, O'Connell R, Katz DL, Manson JE, Hutchison WR, Landau C, et al; Healthcare Professionals for Healthcare Reform. The expanding medical and behavioral resources with access to care for everyone health plan. Ann Intern Med. 2009;150:490-2. [PMID: 19258548] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Richard L. O'Brien, MD; Donald Frey, MDAffiliations: From Creighton University, Omaha, NE 68178.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Expanding Medical and Behavioral Resources with Access to Care for Everyone Health Plan Gilead I Lancaster , Ryan O'Connell , David L. Katz , JoAnn E. Manson , William R. Hutchison , Charles Landau , Kimberly A. Yonkers , and Comments and Critiques on the EMBRACE Health Care Reform Plan Christopher K. Johnson Comments and Critiques on the EMBRACE Health Care Reform Plan Gary R. Gibson Comments and Critiques on the EMBRACE Health Care Reform Plan Gilead I. Lancaster , Ryan O'Connell , and David L. Katz Comments and Critiques on the EMBRACE Health Care Reform Plan Quentin D. Young Metrics 3 November 2009Volume 151, Issue 9Page: 671KeywordsConflicts of interestDisabilitiesFallsHealth careInsuranceQuality of lifeRheumatoid arthritis ePublished: 3 November 2009 Issue Published: 3 November 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
THE EFFECT OF TEMPERATURE ON EXTENSIBILITY OF ISOLATD CORNEUM AND ITS RELATION TO SKIN CHAPING*
Authors: J.D. MIDDLETON
Journal: British Journal of Dermatology (1969)

SUMMARY.— As part of a study on the effect of water on the extensibility of isolated corneum we have investigated the effect of temperature on extensibility under conditions where the corneum water content was kept as constant as possible. The results showed that corneum extensibility was decreased at lower temperatures. These results may be of significance in the appearance of skin chapping in winter. The incidence of chapping has been related to low dewpoints and the hypothesis was that a low dewpoint leads to a low corneum water content. Our results suggest that low temperatures play an equally important part and that chapping is not related purely to a low corneum water content.