tbuckley/cabot-search huggingface dataset:
Use of Alcohol—An Appeal to Physicians.
Authors: T. D. Crothers
Journal: JAMA (1902)

Hartford, Conn., Nov. 6, 1902. <h3>To the Editor:</h3> —It is a fact not often recognized that the medical profession as a body have during the last half century made three distinct declarations concerning the nature and effects of alcohol on the body. These declarations grew out of a sense of alarm at the dangerous use of alcohol and the need of a protest by medical men acting independently. The first was made in 1839, and was signed by 78 leading physicians in London, Edinburgh and Glasgow. It was a public statement declaring the use of alcohol as a food and beverage to be injurious and pointing out its damage to the body. The second declaration appeared in 1847 and declared that alcohol was not needed in health and that total abstinence gave the strongest promise of longevity. This declaration was signed by 2,000 physicians in England, on the continent and
Coinheritance of two rare genodermatoses (Papillon-Lefevre syndrome and oculocutaneous albinism type 1) in two families: a genetic study
Authors: C. Hewitt, C-L. Wu, F.N. Hattab, W. Amin, K.A. Ghaffar, C. Toomes, P. Sloan, A.P. Read, J.A. James, N.S. Thakker
Journal: British Journal of Dermatology (2004)

Journal Article Coinheritance of two rare genodermatoses (Papillon–Lefèvre syndrome and oculocutaneous albinism type 1) in two families: a genetic study Get access C. Hewitt, C. Hewitt Unit of Medical Genetics, University of Manchester and the Regional Molecular Genetics Service, St Mary's Hospital, Manchester M13 0JH, U.K Search for other works by this author on: Oxford Academic Google Scholar C‐L. Wu, C‐L. Wu Unit of Medical Genetics, University of Manchester and the Regional Molecular Genetics Service, St Mary's Hospital, Manchester M13 0JH, U.K Search for other works by this author on: Oxford Academic Google Scholar F.N. Hattab, F.N. Hattab Dental Health Services, Primary Health Care, Ministry of Public Health, Doha, Qatar Search for other works by this author on: Oxford Academic Google Scholar W. Amin, W. Amin Department of Conservative Dentistry and Prosthodontics, Faculty of Dentistry, University of Jordan, Amman, Jordan Search for other works by this author on: Oxford Academic Google Scholar K.A. Ghaffar, K.A. Ghaffar Department of Oral Diagnosis and Periodontology, Eins‐Shams University, Cairo, Egypt Search for other works by this author on: Oxford Academic Google Scholar C. Toomes, C. Toomes Unit of Medical Genetics, University of Manchester and the Regional Molecular Genetics Service, St Mary's Hospital, Manchester M13 0JH, U.K Search for other works by this author on: Oxford Academic Google Scholar P. Sloan, P. Sloan Unit of Oral Pathology, University of Manchester Dental School, Manchester, U.K Search for other works by this author on: Oxford Academic Google Scholar A.P. Read, A.P. Read Unit of Medical Genetics, University of Manchester and the Regional Molecular Genetics Service, St Mary's Hospital, Manchester M13 0JH, U.K Search for other works by this author on: Oxford Academic Google Scholar J.A. James, J.A. James Unit of Oral Pathology, University of Manchester Dental School, Manchester, U.K Search for other works by this author on: Oxford Academic Google Scholar N.S. Thakker N.S. Thakker Unit of Medical Genetics, University of Manchester and the Regional Molecular Genetics Service, St Mary's Hospital, Manchester M13 0JH, U.KUnit of Oral Pathology, University of Manchester Dental School, Manchester, U.K Nalin Thakker. E‐mail: nthakker@manchester.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 151, Issue 6, 1 December 2004, Pages 1261–1265, https://doi.org/10.1111/j.1365-2133.2004.06237.x Published: 01 December 2004 Article history Accepted: 16 May 2004 Published: 01 December 2004
Pulsed Doppler ultrasound compared with thermodilution for monitoring cardiac output responses to changing left ventricular function
Authors: L. M R BOJANOWSKl, A. D TIMMIS, Y. C NAJM, R. G GOSLING
Journal: Cardiovascular Research (1987)

To determine the responsiveness of the pulsed Doppler technique to pacing and drug induced changes in left ventricular function 125 simultaneous cardiac output measurements by pulsed Doppler ultrasound and thermodilution were compared in 12 patients. The Doppler velocity frequencies were analysed using a signal averaging process and the validity of this method first tested in vitro. This showed almost perfect linearity of pulsed Doppler and electromagnetic flow determinations in a test rig. Although data points showed greater scatter in the clinical study, a highly significant linear relation between cardiac output measurements by pulsed Doppler and thermodilution was confirmed by regression analysis (r=0.88, p<0.001). Certain mean values for cardiac output by the two techniques differed, however, by up to 0.9 litre·min−1. Despite this, changes in cardiac output in response to pacing, inotropic stimulation with dobutamine, and vasodilatation with nitrates were directionally similar, indicating a useful role for the pulsed Doppler technique in monitoring responses to treatment in the intensive care unit. Pulsed Doppler also provided a simple measure of left ventricular contractile function. Thus the inotropic response to dobutamine produced a significant rise in peak aortic flow velocity, and this variable was unaffected by either pacing or nitrate induced vasodilatation.
The erythemal response of human skin to ultraviolet radiation
Authors: P.M. FARR, B.L. DIFFEY
Journal: British Journal of Dermatology (1985)

A reflectance instrument was used to measure objectively the erythemal response of human skin to ultraviolet radiation. Dose-response curves have been constructed for four radiation wavelengths. In each case, the measured increase in erythema was found to be linearly related to the logarithm of the dose of ultraviolet radiation. Significantly different slopes of response were obtained for radiation of 254 and 280 nm compared with 300 and 313 nm radiation. The relevance of these findings is discussed with relation to the mechanism of erythema production and the erythema action spectrum.
When imagination is difficult: Metacognitive experiences at the fault lines of reality
Authors: Lawrence J. Sanna
Journal: Behavioral and Brain Sciences (2007)

Abstract Imagination and rational thought may be guided by identical principles, and Byrne's (2005) analysis expertly synthesizes a diverse literature on counterfactual thinking. Further attention should be paid to metacognitive experiences, like ease or difficulty of thought generation, which accompany the imaginative process. Only by considering metacognitive experiences along with the content of what people imagine can we fully understand imagination.
The Treatment of Asthma
Authors: N. S. Davis
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Feasibility of outpatient management after intra-articular yttrium-90: comparison of two regimens.
Authors: P L Williams, J C Crawley, A M Freeman, D C Lloyd, J M Gumpel
Journal: BMJ (1981)

In a study comparing two regimens of treatment after intra-articular irradiation of the knee with yttrium-90 one group of patients was allocated to bed rest for 48 hours in hospital and the other to mobilisation at home. Initially a Robert-Jones orthopaedic bandage was applied to the knee in all patients, serving as a semi-rigid splint, but as loss of isotope from the knee was appreciable in the mobilised patients, subsequent patients were sent home with the knee in a plaster-of-Paris cylinder. No difference in extra-articular spread or chromosomal damage was found between the patients sent home with their knee in a rigid splint and those treated by bed rest. Clinical outcome at three months was satisfactory in all three groups. These results show that rigid splinting is essential in reducing extra-articular spread of the isotope but that bed rest is not necessary. Increases in intra-articular pressure associated with quadriceps muscle activity combined with flexion of the knee may be the most important factor affecting extra-articular spread of isotope.
Abstract 479: The effects of sarcophine-diol (SD) on melanoma B16F10 cell line
Authors: Pawel T. Szymanski, Bhimanna Kuppast, Pratik Muley, Hesham Fahmy
Journal: Cancer Research (2012)

Abstract Sarcophine diol (SD) is a non-toxic semi-synthetic derivative of sarcophine, a marine natural product. Previously, we studied the chemopreventive effects of SD on non-melanoma tumor development using both animal and cellular models. In this current study, we used the mouse melanoma B16F10 cell line to investigate the possible effects of SD on melanoma cell development. We found that SD at a 250 µM concentrations inhibits cell duplication. Melanoma cells treated with SD do not form the contractile ring, a multi-protein complex involved in cell division. As a result of cytoskeleton modification, cells treated with SD do not show the ability to carry out de novo synthesis of DNA, and their DNA show a high degree of fragmentation compared to untreated controls. To explore the molecular mechanism(s) involved in the disassembly of the contractile machinery, our studies show that SD treatment inhibits cell membrane permeability for small molecular mass compounds (e.g. ethidium bromide which is used as an indicator for cell permeability to Ca2+ ions). These findings are consistent with the observation that SD increases cleavage of phospholipase A2 (PLA2), resulting in low PLA2 enzymatic activity. These findings are also consistent with the observation that SD, in a time- and concentration-dependent manner, inhibits the expression level of the cyclooxygenase-2 (Cox-2). As a result of the decline in membrane permeability in SD treated cells and the negative effect of SD on the protein level of phospholipase C (PLC), which both affect the activity of contractile machinery, the non-dividing cells undergo apoptosis. The latter notion is supported by findings that SD inhibits the expression of STAT-3 (signal transducer and activator of transcription protein), and cyclin D1 (an activator of cyclin-dependent kinase 4, Cdk4). SD treatment also enhances the cellular level of the tumor suppressing protein 53 (p53) and stimulates cleavage of the nuclear poly(ADP-ribose) polymerase (cleaved-PARP). SD also enhances the cellular level of cleaved-Caspase-3, -8, -9 and stimulates enzymatic activities of Caspase-3, -8 and -9. All these findings, in addition to inhibition of cell viability, suggest that SD most likely inhibits melanoma cell growth by arresting the cell-division cycle in a Go quiescent phase and simultaneously activates apoptosis via extrinsic and intrinsic pathways. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 479. doi:1538-7445.AM2012-479
Cost-effectiveness of Noninvasive Testing for Osteomyelitis
Authors: P. Todd Makler
Journal: JAMA (1995)

<h3>To the Editor.</h3> — The article by Dr Eckman and colleagues<sup>1</sup>regarding cost-effectiveness analysis in the diagnosis of foot infections is an extensive analysis that is fundamentally flawed because of an error in the assumptions about the costs of the procedures. The cost of the technetium Tc 99m bone scan is listed as $719 and the cost of the indium In 111—labeled leukocyte scan is put at $447. It may be that these numbers reflect the charges of the studies in the Boston, Mass, area, but these numbers do not reflect the cost of the studies. First, the listed costs of the studies are not representative. The 1993 Medicare resource-based relative value scale—based reimbursement for a three-phase bone scan is $204.06 (global payment comprising professional and technical fees), which is only a fraction of the $719 listed in Table 4 in the article. Second, the factor of concern is
Introduction to Neuroanatomy
Authors: George B. Udvarhelyi
Journal: JAMA (1962)

It is a pleasure to read a book which stimulates simplification and conceptual thinking. Dr. Bowsher's small, but concise, booklet does not claim to give us any sophisticated new ideas. However, with admirable clarity he gives us a succinct, well-rounded concept of neuroanatomy. As Lord Cohen points out in his preface, the author helps to break down the fears and embarrassment students have in trying to understand the complicated structure of the central nervous system. The author gives all of the important morphological description of the central nervous system and at the same time stresses the importance of function. The presentation is clear and the semidiagrammatic illustrations are very useful. This reviewer especially enjoyed the various diagrams explaining the connection of the different systems. As this little book is basically intended for the use of undergraduates and not specialists, it is appropriate that no bibliographic data have been incorporated. However,
Endogenous Carbon Monoxide Production
Authors: Ronald F. Coburn
Journal: New England Journal of Medicine (1970)

IT has been known since the late nineteenth century that blood of man and animals contains small quantities of carbon monoxide (CO)1; however, only in relatively recent years has it been possible to demonstrate that CO is produced in the body,2 , 3 to make measurements of rates of CO production and to work out some of the processes that influence this rate and the quantity of CO in the body stores. The rate of CO production (Vco) in young normal resting human male subjects averages 0.42 ± 0.07 ml per hour STPD† (6.1 μ1 per hour per kilogram). . . .
Pachyonychia congenita complicated by hidradenitis suppurativa: a family study
Authors: P. TODD, J. GARIOCH, M. RADEMAKER, W. SUSSKIND, C. GEMELL, J. THOMSON
Journal: British Journal of Dermatology (1990)

A family is described in which five of the six members with the Jackson–Lawler type of pachyonychia congenita also had varying degrees of hidradenitis suppurativa. We suggest an association between this type of pachyonychia congenita and hidradenitis suppurativa.
Stress and Disease: A Review of Principles
Authors: D. O'Neill
Journal: BMJ (1958)

The term " stress " is here taken to mean the internal or resisting force brought into being in the human organism by interaction with the environment (Wolff, 1952).In Western society one of the most important forms of such interaction in the production of illness is that between man and his fellow-beings.The stresses arising from this source are manifested in disturbances of thought, feeling and behaviour, and in disturbances of bodily function and structure.These may be brief and insignificant, or so persistent and troublesome as to constitute an illness.The group of illnesses in which stress is a
A Study of the Relevance to Myocardial Infarction of Social Factors: A Study of Italians Living in Roseto, Pennsylvania, and in Other American Communities.
Authors: Stewart Wolf
Journal: Annals of Internal Medicine (1965)

s1 May 1965A Study of the Relevance to Myocardial Infarction of Social Factors: A Study of Italians Living in Roseto, Pennsylvania, and in Other American Communities.Stewart Wolf, M.D., F.A.C.P., John G. Bruhn, Ph.D., James W. Hampton, M.D., Clarke Stout, M.D.Stewart Wolf, M.D., F.A.C.P.Search for more papers by this author, John G. Bruhn, Ph.D.Search for more papers by this author, James W. Hampton, M.D.Search for more papers by this author, Clarke Stout, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1073_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn Italian-American community, Roseto, Pennsylvania, has been shown to have an incidence of death due to myocardial infarction of less than half that of four neighboring communities, which are predominantly non-Italian. There were no deaths due to myocardial infarction under age 47 in Roseto from 1955 to 1963 whereas several Italians living in the other communities had died in their thirties and forties of myocardial infarctions. A survey of Italian male relatives of Rosetans who lived elsewhere revealed that the prevalence of obesity, hypertension and diabetes was similar to that of the Rosetans. However, the prevalence of electrocardiographic evidences of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Oklahoma City, Oklahoma PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1073-1073KeywordsElectrocardiographyHypertensionMyocardial infarctionObesity Issue Published: 1 May 1965 PDF DownloadLoading ...
Chromatin Remodeling Is a Key Mechanism Underlying Cocaine-Induced Plasticity in Striatum
Authors: Arvind Kumar, Kwang-Ho Choi, William Renthal, Nadia M. Tsankova, David E.H. Theobald, Hoang-Trang Truong, Scott J. Russo, Quincey LaPlant, Teresa S. Sasaki, Kimberly N. Whistler, Rachael L. Neve, David W. Self, Eric J. Nestler
Journal: Neuron (2005)
Early management of unstable angina and non-ST segment elevation myocardial infarction: summary of NICE guidance
Authors: E. Crowe, K. Lovibond, H. Gray, R. Henderson, T. Krause, J. Camm
Journal: BMJ (2010)

Acute coronary syndromes are a common cause of morbidity and mortality, and they place a major burden on healthcare providers in both industrialised and developing countries. A range of drug treatments and invasive management strategies is available, but the potential to reduce ischaemic risk must be balanced against the increased risk of bleeding complications. This article summarises recommendations made in the National Institute for Health and Clinical Excellence (NICE) guideline for the management of unstable angina and non-ST elevation myocardial infarction, including risk assessment, drug treatment, invasive management, cardiac rehabilitation, and planning of discharge.1 Patients with acute coronary syndrome who do not have persistent ST segment elevation on their electrocardiogram (ECG) at presentation are classified as having non-ST elevation myocardial infarction if the serum troponin concentration is raised and as having unstable angina if it is normal.

NICE recommendations are based on systematic reviews of best available evidence and explicit consideration of cost effectiveness. When minimal evidence is available, recommendations are based on the experience and opinion of the Guideline Development Group (GDG) on what constitutes good practice.

### Risk assessment

As soon as the diagnosis is made, formally assess the risk of future adverse cardiovascular events using an established risk scoring system (for example, global registry of acute cardiac events.2 [ Based on observational study and registry database evidence ]

Include in the formal risk assessment:

[ All based on registry database evidence and the experience and opinion of the …
Inside the oven
Authors: H. Rosenthal
Journal: BMJ (1996)

When I was in hospital for removal of an adrenal carcinoma the most unpleasant experience was the magnetic resonance imaging scan. Despite written information and reassurances offered, I was completely unprepared for it. Why was it so traumatic?

I now understand my distress by setting it within the context of being terminally ill. I knew that the tumour was malignant, that it was large and producing high levels of cortisol and other hormones. It created terrifying rushing sensations. The metyrapone that I was taking to reduce my blood cortisol made me nauseous and dizzy. My legs were weakening. I was terrified that I would not live to see my children again. Any resilience I had ebbed away. I had already been processed through many high tech investigations. I knew that the …
Influenza vaccination rates and informed consent in Dutch nursing homes: survey of nursing home physicians
Authors: M. Verweij
Journal: BMJ (2002)

Influenza is a major cause of morbidity and mortality among residents of nursing homes. 1 Many nursing homes therefore aim at high vaccination rates.To meet this aim some homes use tacit consent policies, in which the vaccine is given unless residents or their proxies state that they do not want it.Such policies deviate from standard (express) consent procedures, which require that vaccination occurs only if the resident or his or her proxy gives consent.Is this deviation from standard informed consent procedures justified?We explored consent procedures and vaccination rates in Dutch nursing homes to determine the effects of current practice.
Prostaglandins: Physiological Pharmacological and Pathological Aspects
Authors: A. Klopper
Journal: BMJ (1976)

complication in an otherwise satisfying opera- tion, yet the cause is still unknown and treat- ment difficult.This is a book for all surgeons doing breast surgery, plastic surgery, oncologists, almost anyone who can use a knife.It is expensive but surely worth the money.Beautifully produced and profusely illustrated, it is likely to become the standard work on the subject.
Digit ratio (2D:4D) as a marker for mental disorders: Low (masculinized) 2D:4D in autism-spectrum disorders, high (feminized) 2D:4D in schizophrenic-spectrum disorders
Authors: Martin Voracek
Journal: Behavioral and Brain Sciences (2008)

Abstract Augmenting and supplementing the arguments of Crespi &amp; Badcock (C&amp;B), I show that digit ratio (2D:4D), a putative marker of prenatal androgen action, indeed appears differentially altered in autism-spectrum disorders (lower/masculinized) versus schizophrenic-spectrum disorders (higher/feminized). Consistent with C&amp;B's framework, some evidence (substantial heritability, assortative mating, sex-specific familial transmission) points to possible sex chromosome and imprinted genes effects on 2D:4D expression.