tbuckley/cabot-search huggingface dataset:
Previous beat contraction history alters mechanical restitution in the isolated left ventricle
Authors: B. K Slinker, K. B Campbell
Journal: Cardiovascular Research (1994)

Journal Article Previous beat contraction history alters mechanical restitution in the isolated left ventricle Get access Bryan K Slinker, Bryan K Slinker Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA 99164-6520, USA: B K Slinker, K B Campbell. Correspondence to Dr Slinker. Search for other works by this author on: Oxford Academic PubMed Google Scholar Kenneth B Campbell Kenneth B Campbell Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA 99164-6520, USA: B K Slinker, K B Campbell. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 4, April 1994, Pages 535–541, https://doi.org/10.1093/cvr/28.4.535 Published: 01 April 1994 Article history Received: 06 April 1993 Accepted: 22 November 1993 Published: 01 April 1994
Periocular atypical mycobacterial infections
Authors: Warren J Chang, David T Tse, Robert H Rosa, Darlene Miller
Journal: Ophthalmology (1999)

ObjectiveTo examine the clinical characteristics and management of periocular infections caused by atypical mycobacteria.DesignRetrospective, noncomparative case series.ParticipantsSix patients were identified with periocular atypical mycobacterial infections: four with Mycobacterium chelonae and two with Mycobacterium fortuitum.InterventionThe treatment of these infections included removal of the foreign bodies with debridement of the lesions. Specimens were sent for histopathologic examination, routine cultures, and fresh tissue for culture after homogenization.Main outcome measuresA retrospective review of culture-proven atypical mycobacterial infections involving the periocular tissues was performed. Charts were reviewed for age, gender, infectious organism, medical history, surgical history, presenting symptoms, clinical features, and treatment.ResultsFour associations with infection were identified in these patients: immunosuppression, nasolacrimal duct obstruction, the presence of a foreign body, and a history of recent surgery. All six of the patients had at least one of these associations and five of the patients had at least two. Clinical characteristics that may distinguish atypical mycobacterial infections from acute bacterial infections include subacute presentation, firm nodular lesions, mild erythema, mild tenderness, and minimal purulent discharge. All patients had resolution of their infections after debridement and several weeks of systemic antibiotic therapy guided by susceptibility testing.ConclusionsPeriocular atypical mycobacterial infections are uncommon. The clinical history and examination can raise the suspicion of this infection by revealing the clinical characteristics of these infections. Treatment includes removal of foreign bodies, debridement, and long-term systemic antibiotic therapy.
Varicella–Zoster Virus Vaccine — Grown-ups Need It, Too
Authors: Donald H. Gilden
Journal: New England Journal of Medicine (2005)

A few years ago, I had zoster (shingles) — no surprise, since I was over 60 years of age, and zoster is usually a disease of later life. Fortunately, both the rash and the pain disappeared within a few days. I was grateful not to have to endure the dreaded chronic pain of postherpetic neuralgia, which can last for months or years, and there was no complicating zoster paresis, myelopathy, or vasculopathy. I recalled my first encounter with varicella–zoster virus (VZV) as a child with varicella (chickenpox); I had to stay home from school for nearly a week (not so . . .
Generation and analysis of clonal IgM- and IgG-producing human B cell lines expressing an anti-DNA-associated idiotype.
Authors: A J Manheimer-Lory, A Davidson, D Watkins, N R Hannigan, B A Diamond
Journal: Journal of Clinical Investigation (1991)

This study describes a methodology for generating stable, cloned, EBV-transformed IgG- and IgM-producing human B cell lines. Using these lines we have characterized immunoglobulin V gene utilization in an anti-DNA-associated idiotypic system. The 31 anti-DNA-associated idiotype is encoded preferentially by the VK1 gene family, and, in all probability, reflects a germ line gene-encoded framework determinant. Analysis of these lines indicates that the DNA-binding antibodies produced by B cell lines from SLE patients may differ from DNA binding myeloma proteins and from natural autoantibodies.
Lead-Paint Poisoning Prevention: An Opportunity Forfeited
Authors: Herbert L. Needleman
Journal: New England Journal of Medicine (1975)

Lead is a useful metal and an enduring danger, one whose properties have been valued and exploited since antiquity. Knowledge of its toxic potential is almost as old, and although frequently cited through history, regularly ignored. Recently, an opportunity to reduce a significant source of lead for American children occurred, and was missed.The Lead Paint Poisoning Prevention Act of 1971, amended in 1973, called for the automatic reduction of lead in household paint from 0.5 to 0.06 per cent on December 31, 1974, unless the chairman of Consumer Product Safety Commission ruled otherwise. On December 23, 1974, the chairman . . .
Cytomegalovirus induction of tumor necrosis factor-alpha by human monocytes and mucosal macrophages.
Authors: P D Smith, S S Saini, M Raffeld, J F Manischewitz, S M Wahl
Journal: Journal of Clinical Investigation (1992)

Cytomegalovirus (CMV) is a major cause of inflammatory organ disease in immunosuppressed persons. To elucidate the mechanisms of CMV-induced inflammation, we investigated whether tumor necrosis factor-alpha (TNF-alpha) was involved in the pathogenesis of CMV colitis in patients with AIDS. In in situ hybridization experiments, TNF-alpha mRNA was shown to be abundantly present in colonic mucosa from AIDS patients with CMV colitis but not in colonic mucosa from control (AIDS and normal) subjects. The TNF-alpha transcripts, identified in macrophage-like cells containing cytomegalic inclusions, were positively associated with CMV, but not HIV-1, within the mucosa. In in vitro experiments, a patient-derived isolate of CMV, but not HIV-1Ba-L, induced human monocytes to express TNF-alpha mRNA and to release increased levels of TNF-alpha peptide following stimulation. CMV induction of TNF-alpha may play a critical role in CMV-induced inflammation and, since TNF-alpha upregulates expression of HIV-1, offers a mechanism by which CMV could serve as a co-factor for HIV-1 expression without both viruses infecting the same cell.
AIDS in Europe.
Authors: P Ebbesen, R J Biggar, M Melbye
Journal: BMJ (1983)

United States next year.33Though the number of cases of AIDS in Europe is, fortunately, far smaller, these estimates provide sobering portents for the future.The health planners and science resource managers of Europe must make use of whatever lag time exists between the epidemic curves in the United States and Europe to prepare the necessary support for the coming needs-both clinical and research needs.
Fulminating Ulcerative Colitis
Authors: T. A. Boxall
Journal: BMJ (1967)

MEDICtreated, with results which refute this state- ment.Infections caused by both Gram- positive and Gram-negative micro-organisms have responded to hetacillin in the same or lower dosages than those recommended for ampicillin.Details of these clinical studies will appear in print shortly.-Iam, etc.,
MYOSITIS AND MYOTONIA IN A CASE OF MULTICENTRIC RETICULOHISTIOCYTOSIS
Authors: T. E. ANDERSON, A. J. CARR, R. S. CHAPMAN, A. W. DOWNIE, G. D. MACLEAN
Journal: British Journal of Dermatology (1968)

SUMMARY. A case of multicentric reticulohistiocytosis in a young man is presented, associated with a polymyositis in which myotonia was prominent. Both skin nodules and muscle abnormalities reverted to normal with steroid therapy. The cytoplasm of the giant cells in the skin nodules has been shown to contain a glycolipid.
COMPARISON OF THREE INTRAVENOUS BISPHOSPHONATES IN CANCER-ASSOCIATED HYPERCALCAEMIA
Authors: StuartH. Ralston, Uday Patel, WilliamD. Fraser, StephenJ. Gallacher, FrancesJ. Dryburgh, RobertA. Cowan, IainT. Boyle
Journal: The Lancet (1989)
Nitrate contamination of drinking water: relationship with HPRT variant frequency in lymphocyte DNA and urinary excretion of N-nitrosamines.
Authors: J M van Maanen, I J Welle, G Hageman, J W Dallinga, P L Mertens, J C Kleinjans
Journal: Environmental Health Perspectives (1996)

We studied peripheral lymphocyte HPRT variant frequency and endogenous nitrosation in human populations exposed to various nitrate levels in their drinking water. Four test populations of women volunteers were compared. Low and medium tap water nitrate exposure groups (14 and 21 subjects) were using public water supplies with nitrate levels of 0.02 and 17.5 mg/l, respectively. Medium and high well water nitrate exposure groups (6 and 9 subjects) were using private water wells with mean nitrate levels of 25 and 135 mg/l, respectively. Higher nitrate intake by drinking water consumption resulted in a dose-dependent increase in 24-hr urinary nitrate excretion and in increased salivary nitrate and nitrite levels. The mean log variant frequency of peripheral lymphocytes was significantly higher in the medium well water exposure group than in the low and medium tap water exposure groups. An inverse correlation between peripheral lymphocyte labeling index and nitrate concentration of drinking water was observed. Analysis of N-nitrosamine in the urine of 22 subjects by gas chromatography-mass spectrometry revealed the presence of N-nitrosopyrrolidine in 18 subjects. Analysis of the mutagenicity of well water samples showed that a small number of the well water samples were mutagenic in the Ames Salmonella typhimurium test after concentration over XAD-2 resin. In conclusion, consumption of drinking water, especially well water, with high nitrate levels can imply a genotoxic risk for humans as indicated by increased HPRT variant frequencies and by endogenous formation of carcinogenic N-nitroso compounds from nitrate-derived nitrite.
Aortocoronary Bypass Graft
Authors: CLAUDE M. GRONDIN, GILLES LEPAGE, YVES R. CASTONGUAY, CLAUDE MEERE, PIERRE GRONDIN
Journal: Circulation (1971)

Intraoperative measurements of blood flow were made in 70 patients in whom a total of 103 venous bypass grafts had been inserted from the aorta to the right, the left anterior descending, or the circumflex coronary artery. Cineangiographic evaluation of graft patency was performed in all patients. Overall patency rate was 90.3%. Flow in all bypass grafts averaged 68 ml/min. All grafts with flow of 20 ml or less or which failed to respond to the injection of 20 mg of papaverine became occluded. All grafts with flow greater than 45 ml/min remained open.
Corticosteroids and tuberculosis.
Authors: M B Allen, N J Cooke
Journal: BMJ (1991)

dependency nursing for certain patients.We do not yet know which patients would benefit from such attention, but large trials would help us to define the true incidence of morbidity and its relation to the preoperative state and procedure.Different specialists will need to cooperate to fill in the gaps in our understanding of optional preoperative, perioperative, and postoperative management in elderly patients.The anaesthetist interested in geriatrics is not a subspecialist but someone concentrating on the biggest challenge presented to anaesthetists today.It is here that most can be learnt for the benefit of patients of all ages.
Quantitative assessment of right and left ventricular growth in the human fetal heart: a pathoanatomic study.
Authors: M G St John Sutton, J S Raichlen, N Reichek, D S Huff
Journal: Circulation (1984)

We quantitated the growth patterns of the normal fetal heart and the right and left ventricles from postmortem hearts obtained from 55 spontaneously aborted human fetuses from the completion of cardiogenesis to term. Fetal gestational age was assessed by menstrual history of the mother, crown-rump length, head circumference, and body weight and ranged from 8 to 40 weeks. Each heart was perfused and fixed at constant pressure and dissected to obtain right and left ventricular free wall, left ventricular, and total heart weights. Right and left ventricular free wall thicknesses were measured and the respective surface areas were calculated. The changes in each of these parameters with gestational age were examined by regression analysis. Total heart and right and left ventricular wall weights increased linearly with body weight, but exponentially with head circumference, crown-rump length, and menstrual history. Right and left ventricular free wall weights were similar throughout gestation and the percent that each contributed to total heart weight were constant at 29 +/- 2% and 30 +/- 2%, respectively. Right and left ventricular wall thicknesses did not differ significantly, increasing linearly with menstrual age, crown-rump length, head circumference, and body weight from 8 to 40 weeks. The surface areas of the right and left ventricular free walls that we used as an index of changing ventricular architecture were indistinguishable throughout the period of gestation studied.(ABSTRACT TRUNCATED AT 250 WORDS)
338 RISK OF EARLY ATHEROSCLEROSIS BY CAROTID ARTERY INTIMA-MEDIA THICKNESS IN PATIENTS WITH NON ALCOHOLIC FATTY LIVER DISEASE AND LOW VISCERAL ADIPOSITY
Authors: A.L. Fracanzani, M. Porzio, L. Burdick, C. Bertelli, L. Valenti, D. Bignamini, E. Fatta, C. Masetti, S. Fargion
Journal: Journal of Hepatology (2010)
Abstract 2320: In vivo characterization of small molecule inhibitors of replication protein A: Implications for cancer therapy
Authors: Tracy M. Neher, Diane M. Bodenmiller, John J. Turchi, Shadia I. Jalal
Journal: Cancer Research (2011)

Abstract The nucleotide excision repair (NER) pathway catalyzes the removal of bulky DNA adducts from the genome and aids in maintaining genomic stability. The NER pathway has two subsets; global-genomic NER (GG-NER) and transcription coupled NER (TC-NER). They differ mainly in steps involving the recognition of the DNA lesion. The NER pathway plays a very important role in the recognition, removal and repair of intra-strand adducts induced by cisplatin; a commonly used chemotherapeutic agent. Previous studies have demonstrated that a decrease in NER activity enhances cancer sensitivity to cisplatin. The recognition of DNA damage involves a series of proteins including the xeroderma pigmentosum group A and C proteins (XPA and XPC) and Replication Protein A (RPA). RPA, a single-strand DNA binding protein, plays an essential role in both NER sub-pathways in addition to DNA replication. This makes RPA an ideal protein to target cancer therapy. Previous studies from our lab identified compounds which disrupt RPA's ssDNA binding activity in vitro. We sought to further characterize these RPA small molecule inhibitors (SMI) in cancer cell culture models. Using lung and ovarian cancer cell lines, viability curves, apoptosis assays, cell cycle analysis, signaling and transcription regulation were analyzed with single agent treatment and in combination with cisplatin. Results demonstrate potent cell killing in single agent studies and lengthening of the G1/ S-phase of the cell cycle. RPA SMIs also induce cell death through a classical apoptotic pathway. Additionally, data demonstrate a synergistic relationship with cisplatin with sequential treatment. Cell signaling analyses and DNA repair gene expression studies are ongoing to further determine the DNA damage response induced by these compounds. Overall these data demonstrate the therapeutic potential of SMI of RPA in treatment of cancer as single agents and in combination with cisplatin. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2320. doi:10.1158/1538-7445.AM2011-2320
Hydrophilic but not hydrophobic bile acids prevent gallbladder muscle dysfunction in acute cholecystitis
Authors: Zuo-Liang Xiao, Piero Biancani, Martin C. Carey, Jose Behar
Journal: Hepatology (2003)

The pathogenesis of acute cholecystitis (AC) is controversial. Bile acids may be involved in the pathogenesis of AC because the hydrophobic chenodeoxycholic acid (CDCA) reproduced in vitro the muscle dysfunction observed in AC and was prevented by the hydrophilic ursodeoxycholic acid (UDCA). The present study examined the in vivo effects of UDCA or CDCA on gallbladder muscle dysfunction caused by AC. Guinea pigs were treated with placebo, UDCA, or CDCA for 2 weeks before sham operation or induction of AC by bile duct ligation (BDL) for 3 days. Pretreatment with oral UDCA prevented the defective contraction in response to agonists (acetylcholine [ACh], cholecystokinin 8 [CCK–8], and KCl) that occurs after BDL. Prostaglandin (PG) E 2 –induced contraction remained normal in the placebo and UDCA–treated groups but was impaired in the CDCA–treated group. Treatment with UDCA also prevented the expected increase in the levels of H 2 O 2 , lipid peroxidation, and PGE 2 content in the placebo–treated AC group, whereas CDCA caused further increases in these oxidative stress markers. The binding capacity of PGE 2 to its receptors and the activity of catalase were reduced after treatment with CDCA. Treatment with UDCA enriched gallbladder bile acids with its conjugates and reduced the percentage of CDCA conjugates. In contrast, treatment with CDCA significantly decreased the percentage of UDCA in bile. In conclusion, oral treatment with UDCA prevents gallbladder muscle damage caused by BDL, whereas oral treatment with CDCA worsens the defective muscle contractility and the oxidative stress.
Specificity of pH and osmolality of early morning urine sample in assessing distal renal tubular function in children: results in healthy children
Authors: R. Skinner, M. Cole, A. D J Pearson, M. G Coulthard, A. W Craft
Journal: BMJ (1996)

Table 1-Results of tests for hepatitis B markers in 126 patients with chronic hepatitis C No of patients
Automated microinjection of cell-polymer suspensions in 3D ECM scaffolds for high-throughput quantitative cancer invasion screens
Authors: Hoa H. Truong, Jan de Sonneville, Veerander P.S. Ghotra, Jiangling Xiong, Leo Price, Pancras C.W. Hogendoorn, Herman H. Spaink, Bob van de Water, Erik H.J. Danen
Journal: Biomaterials (2011)
Transplantation of a donor liver with haemochromatosis: evidence against an inherited intrahepatic defect.
Authors: P C Adams, C N Ghent, D R Grant, J V Frei, W J Wall
Journal: Gut (1991)

An iron loaded liver from a 40 year old man with occult haemochromatosis was transplanted into a 19 year old woman with acute liver failure secondary to a paracetamol overdose. Increased parenchymal hepatic iron was found in a liver specimen at biopsy undertaken because of mild rejection 30 days after transplantation. After transplantation the patient had two episodes of liver rejection confirmed by biopsy. The hepatic iron concentration fell from 161 mumol/g on day 30 after transplant to 26.5 mumol/g (normal less than 40) on day 210. Iron absorption, measured 45 days after transplant, was in the normal range at 12.4%. The rapid fall in hepatic iron and the normal iron absorption study result suggest that the genetic defect of haemochromatosis is not exclusively an intrahepatic defect.
ULTRAVIOLET RAYS FOR FINGER PRINTING
Authors: M. A. Aaronson
Journal: JAMA (1927)

<h3>To the Editor:</h3> —Having observed the rapidity with which the soluble silver salts become decolorized in the presence of organic fatty acids under the action of the middle chain of ultraviolet rays, I wondered whether or not it could be used as a rapid method of finger-printing. A practical demonstration was arranged before Major Kimberling and Sergeants Hoch and Cooper of the New Jersey Bureau of Identification, with remarkable results. Impressions were developed in ten seconds from all forms of paper, wearing apparel such as collars, shirts and cuffs, and, where the skin surface is smooth, directly from the human skin. Mothers' finger prints on infants were distinctly read and classified. Impressions developed on paper are permanent and cannot be erased, as with the powder-brush method.
Recognition and Surgical Repair of Superior Mesenteric Arteriovenous Fistula
Authors: ROBERT G. SUMNER, PHILIP C. KISTLER, WILLIAM F. BARRY, HENRY D. McINTOSH
Journal: Circulation (1963)

A patient is described with a traumatic arteriovenous shunt from the superior mesenteric artery to the superior mesenteric vein. The patient had no symptoms referable to this fistula 3 months after a gunshot wound to the abdomen. The diagnostic feature was a continuous bruit in the supraumbilical area. The radiographic technics used in determining the nature of this patient's fistula are described. This is the first reported case of a traumatic superior mesenteric arteriovenous fistula suspected clinically, demonstrated radiographically, and successfully repaired surgically. Although experience with such fistulas is limited, the fatal outcome of the only other case in the literature (not recognized ante mortem) indicates the need for careful auscultation over all abdominal surgical incisions and sites of trauma at regular intervals.
THE CONSERVATION OR RESTORATION OF NORMAL ANATOMY IN GYNECOLOGIC SURGERY.
Authors: DANIEL H. CRAIG
Journal: JAMA (1905)

During the past few years a great wave of conservatism has agitated the entire gynecologic fraternity, not only throughout this country, but also Europe, although it must be admitted that conservatism has not yet achieved the following it deserves even here. The French and to a less degree the English and German gynecologist still vastly prefers to do a high amputation of the cervix or even a vaginal hysterectomy in cases in which better symptomatic, functional and anatomic cures, together with a more complete conservation of the child-bearing function, may be obtained by a tracheloplasty. In France it is true that ovarian conservation has received great stimulation by the well-known work of Jayle and his confrères in regard to the internal secretion of the ovary. In our own country I feel certain that I am not overstating the fact when I say emphatically that it is now a very rare
Transient Local Injury Current in Right Ventricular Electrogram After Implantable Cardioverter-Defibrillator Shock Predicts Heart Failure Progression
Authors: Larisa G. Tereshchenko, Mitchell N. Faddis, Barry J. Fetics, Karl E. Zelik, Igor R. Efimov, Ronald D. Berger
Journal: Journal of the American College of Cardiology (2009)
Die zerebrale Angiographie: Lehrbuch für Klinik und Praxis
Authors: Oscar Sugar
Journal: JAMA (1966)

This so-called second edition is really a completely reworked expanded monograph with 529 figures. Anatomy, physiology, and variations in cerebral vessels occupy half of the text and about a third of the illustrations. Vascular diseases, intracranial tumors (based on 1,303 verified neoplasms), malformations, inflammatory diseases, granulomas, parasites, and traumatic disorders are liberally illustrated and discussed. Numerous drawings help understand the beautifully reproduced roentgenograms (reversed, as is customary in European productions). In all, angiograms of 7,305 patients have been studied and discussed in relation to relevant literature of 1958 to 1964. The only reasons why this magnificent atlas and text might not be considered indispensable for neurologists are the language (German in a very readable style) and the cost. Yet, because of its value it certainly should be accessible to all who wish to expand their knowledge of cerebral angiography.