tbuckley/cabot-search huggingface dataset:
Doctors can benefit from spending time with their dying patients
Authors: S. Mirando
Journal: BMJ (1999)

EDITOR—Haas's observation that few junior doctors witness peaceful expected death mirrors my own experience in a district general hospital.1 I am frequently involved in both suggesting and confirming that a patient is dying and then advising on suitable care and drug treatment to achieve a comfortable death.

I always encourage junior doctors to spend time with a patient they say they can do no more for. A daily contact that shows genuine concern for the patient, …
John Frederick Robinson
Authors: Michael Bond
Journal: BMJ (2004)

Former consultant cardiologist Southern General Hospital, Glasgow (b London 1930; q The London Hospital 1954; FRCP), died from lung cancer on 25 October 2003.​2003.




Figure 1




After registration John served for two years in the Royal Army Medical Corps and served in Malaysia, where he was mentioned in dispatches. Further junior posts at Addenbrooke's Hospital, Cambridge, followed before he returned to The London Hospital. He began his career in cardiology at the Royal Infirmary, Glasgow, before returning to The London Hospital for a further seven years. He became a consultant cardiologist at the Southern General Hospital in 1967. John was latterly consultant in charge of the coronary care unit, retiring in 1995. He leaves a wife, Margaret; three children; and two grandchildren.
Abstract 10281: Frequency, Temporal Onset, and Risk Factors Associated With Acquired Long Qt Syndrome in a Critical Care Population
Authors: Teri M Kozik, Shu-Fen Wung
Journal: Circulation (2010)

Background:  An adverse event associated with medication administration is prolongation of the QT interval on the electrocardiogram known as acquired long QT syndrome (aLQTS). aLQTS increases the risk of developing Torsades de Pointe, a life-threatening cardiac arrhythmia. Prevention of adverse outcomes from aLQTS is challenging because of the multiple classes of medications associated with this condition. Intensive care unit (ICU) patients are at a particularly high risk for developing aLQTS because of multiple medications received; however, frequency of aLQTS in ICUs is unknown. The purpose of this study was to describe in an ICU population, 1) frequency of aLQTS; 2) average time period for the onset of aLQTS; 3) medications and host risk factors associated with aLQTS.   Methods:  QT intervals were collected hourly for 72 hours on 88 consecutive subjects. QT intervals were corrected for heart rate (QTc) using Bazett9s formula. Data points included: baseline (admission), first long, longest, and final QTc measures. Positive aLQTS was defined as a QTc ≥ 500 ms or QTc ≥ 60 ms increase from baseline. Medications and host risk factors were collected.   Results:  aLQTS occurred in 52.3% of the sample. All subjects positive for aLQTS (n=46) had a mean onset of 7.4 + 9.4 hours from ICU admission. Subjects who developed aLQTS after ICU admission (n=32) had a mean onset of 10.6 + 9.5 hours; 14 were positive for aLQTS upon ICU admission. A significant difference was noted between subjects positive and negative for aLQTS who received a QT prolonging medication (p = .012). Thirteen subjects (28.3%) developed aLQTS in the absence of a known QT prolonging medication. Five medications but no other host risk factors were found to be statistically significant predictors for the development of aLQTS.   Conclusions:  aLQTS was present in more than one-half of the sample. Approximately a quarter of the subjects developed aLQTS in the absence of an offending medication, indicating the importance of frequent QTc monitoring in all patients in ICUs. Larger studies to determine host risk factors associated with aLQTS in ICU populations are warranted.
Treatment of Recurrent and Severe <i>Clostridium Difficile</i> Infection
Authors: J.J. Keller, E.J. Kuijper
Journal: Annual Review of Medicine (2015)

Clostridium difficile infection (CDI) is a serious complication of hospitalization and antibiotic use with a high mortality and very high costs. Despite appropriate treatment, a subset of patients develop chronic recurrent CDI. Some other patients develop severe and life-threatening colitis. The risk factors, pathogenesis, and treatment of recurrent CDI and severe CDI are discussed in this review. In particular, fecal microbiota transplantation (FMT) as a treatment strategy is outlined and a treatment algorithm incorporating FMT is described.
Extreme Fluid and Electrolyte Loss Due to Villous Papilloma of the Rectum
Authors: M. G. FitzGerald
Journal: BMJ (1955)

DiscussionAs stated at the beginning of this paper, 16 out of 35 cases were discarded because of the lack of positive proof of the diagnosis.Had we used some of the investigative measures outlined above we would undoubtedly have found a higher incidence of genital tuberculosis among our patients.In many of the 16 discarded cases there was strong presumptive evidence of the disease, and guinea-pig inoculation or culture of the menstrual blood would almost certainly have established the diagnosis in some. SummaryData of 19 cases of tuberculosis of the female genital tract investigated at the American University Hospitals, Beirut, are presented.The commonest complaints and physical findings are discussed and details of the histo- logical findings in biopsy specimens analysed.-Pelvic tuberculosis is not rare.Its incidence among 2,492 gynaecological admissions to this institution is 0.8%.The diagnosis of the disease would be more frequently established if the measures outlined could be routinely used.I wish to thank Dr. D.
A Five-year Follow-up of 100 Neurotic Out-patients
Authors: R. Giel, R. S. Knox, G. M. Carstairs
Journal: BMJ (1964)

Rubella Syndrome-Dudgeon ed.BRNTS not lead to immunological tolerance but is followed by persistence of virus, with subsequent development of active immunity probably by the foetus or early in post-natal life.These findings suggest that as yet the lower limit for immuno- logical competence on the part of the foetus has yet to be determined.We are extremely grateful to our colleagues at the Hospital for Sick Children, Great Ormond Street, in particular to Dr. R. E.
The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis
Authors: Li Li Zhou, Wei Cao, Chao Xie, Jianwei Tian, Zhanmei Zhou, Qiugen Zhou, Ping Zhu, Aiqing Li, Youhua Liu, Toshio Miyata, Fan Fan Hou, Jing Nie
Journal: Kidney International (2012)
European agency rejects links between hyperactivity and food additives
Authors: Rory Watson
Journal: BMJ (2008)

The European Food Safety Authority has rejected suggestions in a study by researchers at Southampton University last year of a link between hyperactivity in children and two mixtures of food colours and the preservative sodium benzoate ( Lancet 2007;370:1560-7; doi: 10.1016/S0140-6736(07)61306-3).

In a highly critical assessment, the authority points to considerable uncertainties, lack of consistency, and absence of information in the study, which was commissioned by the UK Food Standards Agency.

As a result, the authority, which advises the European Union on food safety, maintained that there is no basis for changing present recommendations on the acceptable daily intake of the food colours or …
Behavioral Oncology and the War on Cancer: Partnering with Biomedicine
Authors: Michael E. Stefanek, Michael A. Andrykowski, Caryn Lerman, Sharon Manne, Karen Glanz
Journal: Cancer Research (2009)

Abstract The call for interdisciplinary research in the war on cancer has escalated over the past several years. Behavioral science has played a key role in cancer control, and several exciting opportunities exist and will develop with the ongoing significant advances made in biomedical science. The current article briefly reviews the maturity of behavioral science in the areas of prevention, early detection, and survivorship and how the partnership of behavioral and biomedical science can effectively impact cancer incidence, morbidity, and mortality. [Cancer Res 2009;69(18):7151–6]
ERK and Smads: Getting together for angiogenic sprouting
Authors: M RIZZO
Journal: Cardiovascular Research (2007)

See article by Zhou et al.  [8]  (pages 390–399) in this issue. 

Sprouting of new blood vessels from preexisting capillaries is a multi-faceted and highly orchestrated process that is dependent on a finely tuned balance between pro-angiogenic and anti-angiogenic microenvironmental clues [1]. Perturbations in the equilibrium between pro-angiogenic and anti-angiogenic factors can lead to excessive or defective vascularization [1,2]. Inputs from the microenvironment impinge upon receptive endothelial cells to initiate a multi-step response characterized by degradation of the basement membrane, sprout formation, proliferation, migration along the sprouts and organization into a tubular network of vascular-like structures that ultimately, with the recruitment of mural cells, acquire the anatomical and functional characteristics of mature blood vessels [1]. Microenvironmental clues originating from angiogenic protein and lipid growth factors, tissue oxygenation, adjacent cells, or components of the extracellular matrix are processed by the endothelial cells via intracellular and intercellular signaling pathways that are temporally and spatially segregated to coordinate the initiation, progression and completion of each stage of the angiogenic response [1,3,4]. These signaling pathways, rather than following a linear path, are organized via a cascade of signaling molecules, scaffolding proteins and multi-domain adaptor proteins into highly interconnected networks that provide endothelial cells with a myriad of opportunities for signal integration and crosstalk [5–7]. … 

*Signal Transduction Laboratory, Methodist Research Institute, Clarian Health Partners, 1800 N. Capitol Blvd, Noyes Bldg, Room E504, Indianapolis, IN, 46202, USA. Tel.: +1 317 962 6891; fax: +1 317 962 9369. mrizzo{at}clarian.org
Paroxysmal Ventricular Tachycardia: A Study of One Hundred and Seven Cases
Authors: CHARLES A. ARMBRUST, SAMUEL A. LEVINE
Journal: Circulation (1950)

A review is presented of 107 cases of paroxysmal ventricular tachycardia. In the majority it was associated with acute coronary thrombosis or coronary sclerosis, in some with rheumatic valvular disease, and in others with no organic heart disease. It is generally critical and demands careful attention. Occasional cases are overlooked because only one heart sound is present for each cardiac cycle and the heart rate is misjudged to be one-half the actual rate. The outlook often is serious if the condition is not effectively treated. Therapy generally is successful in controlling the arrhythmia. The most valuable drug is quinidine. Other medications are magnesium sulfate, atropine, potassium salts, and possibly morphine.
Pathophysiology of Diseases Involving Intestinal Brush-Border Proteins
Authors: David H. Alpers, Bellur Seetharam
Journal: New England Journal of Medicine (1977)

The intestinal brush border is a complex organelle that contains hydrolytic enzymes, receptors, other proteins involved in transport and contractile proteins. In this article, we review the molecular organization of brush-border proteins within the whole membrane, and discuss their synthesis and turnover. This knowledge provides a framework for understanding the mechanisms by which certain diseases are associated with changes in brush-border proteins.Distribution of Enzymes within the Brush BorderThe intestinal brush border is composed of a membranous sheet, 6.0 nm wide, lined on the luminal side by a carbohydrate-rich layer known as the glycocalyx (Fig. 1). Attached to the . . .
Myasthenia gravis associated with penicillamine treatment for rheumatoid arthritis.
Authors: R C Bucknall, J Dixon A St, E N Glick, J Woodland, D W Zutshi
Journal: BMJ (1975)

Four patients with rheumatoid arthritis (R.A.) developed myasthenia gravis after taking penicillamine. In one patient withdrawal of the drug was followed by spontaneous remission of the myasthenia, and in two the dose of anticholinesterase was subsequently reduced. In the fourth patient continuing penicillamine treatment was associated with increasingly severe myasthenic features, but on withdrawal of the drug these resolved. As myasthenia gravis rarely complicates R.A. its onset in these patients shortly after the start of penicillamine treatment suggested that penicillamine may have precipitated this condition.
Website of the week: Flying and health
Authors: A. Tonks
Journal: BMJ (2000)

Two articles in this week's BMJ outline the basics of treating people who become unwell while aboard an aircraft. Few doctors will encounter more than one or two of these patients during a lifetime, and, with luck, the problem will not be serious. Far more common are questions from patients about their fitness to fly. Most airlines have their own versions of the Aerospace Medical Association's guidelines. British Airways' Health Services online …
A hypothesis to explain how the sensory cortices respond in the appropriate sensory mode
Authors: G. A Hocker
Journal: Journal of the Royal Society of Medicine (2003)

How does an area of sensory cortex recognize the specific nature of the sensory mode of the stimulus that arrives from the peripheral sensory receptor, when nerve impulses are only all-or-nothing action potentials? Work in animals has shown that an area of sensory cortex can learn in which mode to respond. A period of cortical learning is required for phantom limb phenomena to develop, and for the ocular blind to dream in the visual mode. Arguing from these facts I develop the hypothesis that within the sensory cortices there are neurons that learn by neurotropic factor transport from their sensory receptors to function as surrogates for those receptors, thus enabling sensory cortical response to be modally specific.
Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL
Authors: Raghuveer Singh Mali, Baskar Ramdas, Peilin Ma, Jianjian Shi, Veerendra Munugalavadla, Emily Sims, Lei Wei, Sasidhar Vemula, Sarah C. Nabinger, Charles B. Goodwin, Rebecca J. Chan, Fabiola Traina, Valeria Visconte, Ramon V. Tiu, Timothy A. Lewis, Andrew M. Stern, Qiang Wen, John D. Crispino, H. Scott Boswell, Reuben Kapur
Journal: Cancer Cell (2011)
A Model for Dissemination and Independent Analysis of Industry Data
Authors: Harlan M. Krumholz, Joseph S. Ross
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans
Authors: Alexander S. Banks, Jianze Li, Lisa McKeag, Marta L. Hribal, Masaki Kashiwada, Domenico Accili, Paul B. Rothman
Journal: Journal of Clinical Investigation (2005)

NIDDM is characterized by progressive insulin resistance and the failure of insulin-producing pancreatic beta cells to compensate for this resistance. Hyperinsulinemia, inflammation, and prolonged activation of the insulin receptor (INSR) have been shown to induce insulin resistance by decreasing INSR substrate (IRS) protein levels. Here we describe a role for SOCS7 in regulating insulin signaling. Socs7-deficient mice exhibited lower glucose levels and prolonged hypoglycemia during an insulin tolerance test and increased glucose clearance in a glucose tolerance test. Six-month-old Socs7-deficient mice exhibited increased growth of pancreatic islets with mildly increased fasting insulin levels and hypoglycemia. These defects correlated with increased IRS protein levels and enhanced insulin action in cells lacking SOCS7. Additionally, SOCS7 associated with the INSR and IRS1--molecules that are essential for normal regulation of insulin action. These data suggest that SOCS7 is a potent regulator of glucose homeostasis and insulin signaling.
FIXED DRUG ERUPTION DUE TO CYCLIZINE
Authors: W. A. D. GRIFFITHS, R. D. G. PEACHEY
Journal: British Journal of Dermatology (1970)

Journal Article FIXED DRUG ERUPTION DUE TO CYCLIZINE Get access W. A. D. GRIFFITHS, W. A. D. GRIFFITHS The Department of Dermatology, St Thomas'Hospital, London, S.E.1 Search for other works by this author on: Oxford Academic Google Scholar R. D. G. PEACHEY R. D. G. PEACHEY The Department of Dermatology, St Thomas'Hospital, London, S.E.1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 82, Issue 6, 1 June 1970, Pages 616–617, https://doi.org/10.1111/j.1365-2133.1970.tb06104.x Published: 01 June 1970 Article history Accepted: 12 February 1970 Published: 01 June 1970
THE GROWTH CURVE OF THE LANSING STRAIN OF POLIOMYELITIS VIRUS IN THE CENTRAL NERVOUS SYSTEM OF THE MOUSE
Authors: John D. Ainslie
Journal: The Journal of Experimental Medicine (1952)

After intracerebral inoculation of mice with a 10 per cent suspension (approximately 2000 LD(50)) of the Lansing strain of poliomyelitis virus, the infectivity titer in the brain decreased for approximately 6 hours. It then rose rapidly for 12 to 18 hours to reach titers of over 10(-4). The rise in titer in the spinal cord closely paralleled that in the brain for 18 hours, after which the titer surpassed that in the brain by as much as one log. The infectivity titers in the central nervous system of unparalyzed mice remained between 10(-3.5) and 10(-4.2) for at least 7 days. With the onset of paralysis it was found that the titer was consistently and significantly higher in the spinal cords of paralyzed mice than in their brains or in the brains or cords of unparalyzed mice. After inoculation of 1 per cent virus suspension the increase in titer occurred about 9 hours later than after the inoculation of 10 per cent virus suspension, and the onset of clinical signs of illness was also delayed. Once the titers began to rise, the rate was the same after the inoculation of either concentration of virus, and the maximal levels reached were the same. With both concentrations of virus, maximal infectivity titers in non-paralyzed mice were reached about 9 hours before the onset of signs of poliomyelitis. The significance of these findings is discussed.
THE NEGLECT OF MEDICAL EDUCATION IN THE UNIVERSITIES.
Authors: BAYARD HOLMES
Journal: JAMA (1892)

It is now the fashion for every medical college to have a "University connection." This is a condition, often, as we have reason to know, of the most distant and unstable character. In some cases it means that the medical school is advertised in the announcement of the university and helps to swell the number of university matriculates, but that it is autocratic and independent of the university in all its acts and the university is free from all financial responsibilty in the medical school. In other cases it means that the university is responsible for the housing of the medical department which it has farmed out to a few physicians. These men conduct the affairs of the institution as they see fit and, we regret to say, without regard to the interests of any but themselves. Some of these university medical schools still have seven or eight professors as
RLIP76 and Cancer
Authors: Sanjay Awasthi, Sharad S. Singhal, Yogesh C. Awasthi, Bryan Martin, Jung-Hee Woo, C. Casey Cunningham, Arthur E. Frankel
Journal: Clinical Cancer Research (2008)

Abstract RLIP76 is a multifunctional membrane protein that transports glutathione conjugates of electrophilic compounds and other xenobiotics including chemotherapy agents out of cells. The protein is overexpressed in lung carcinomas, ovarian carcinomas, and melanomas. The protein also binds Ral and participates in mitotic spindle function, clathrin-dependent endocytosis, and triggers GTPase-activating protein activity. It is found throughout the cell, in membrane, cytosol, and the nucleus, and is known to shift between these compartments in response to stress. Loss of RLIP76 by antibody or antisense therapy is associated with increased sensitivity to radiation and chemotherapy. Conversely, liposomally delivered RLIP may treat poisoning and wounds.
"The Great Imposter"
Authors: John I. Ingle
Journal: JAMA (1976)

To the Editor.—   Great Imposter:  of the Temporomandibular Joint (235:2395, 1976) is timely but misnamed, alerting the medical profession to a  long controversial in dentistry.  As Dr Morgan indicated, most people with this  suffer from myofascial pain-dysfunction [MPD] syndrome primarily as a muscle problem. The problem is apparent shortening and an increased stretch reflex of the muscles of mastication, referring pain into the joint. Diseases of the temporomandibular joint is therefore a misnomer.  The apparent shortening of the masticatory muscles is brought on by clenching the jaws and grinding the teeth (bruxism) precipitated by anxiety, and even more by frustration. The solution is to relieve the spasm, as Dr Morgan indicated (moist heat, soft diet, muscle relaxants, dental splints), and then to treat the anxieties underlying the jaw-clenching.  Dr Janet Travell is the nation's expert in the etiology and treatment of MPD syndrome. Her classic articles
THE COMPARABLE EFFECT OF LIFESTYLE AND PHARMACOLOGICAL INTERVENTION TO PREVENT CORONARY ATHEROSCLEROSIS IN JAPANESE EARLY-STAGE DIABETIC PATIENTS - THE DIABETES AND DIFFUSE CORONARY NARROWING (DIANA) STUDY
Authors: Yu Kataoka, Satoshi Yasuda, Yoshihiro Miyamoto, Kazuhiro Sase, Masami Kosuge, Kazuo Kimura, Yasunao Yoshimasa, Shunichi Miyazaki
Journal: Journal of the American College of Cardiology (2010)
A METHOD OF OPERATIVE PROTECTION FROM SKIN INFECTION
Authors: W. E. Johnston
Journal: JAMA (1927)

The usual method of protecting the operative dissection from infection from the skin, by the use of skin towels and towel clamps, has practical disadvantages when applied to limb surgery. The skin towels do not surround the limb but only supplement the drapes in protecting the operative site. This covering, with the added incumbrance of the towel clamps, prevents the free manipulation of the member, so frequently required in limb surgery. To overcome this handicap, Dr. C. W. Peabody of the Henry Ford Hospital Clinic and I have developed the method here described. The limb is painted with a 5 per cent solution of iodine from the fingers or toes to well beyond the next proximal joint from the operative field. Sterile stockinet of suitable width is then rolled on the extremity, so as to cover the limb to the same level. The stockinet should be of such width as to fit
Long-Term, Multicenter Evaluation of Subconjunctival Injection of Triamcinolone for Non-Necrotizing, Noninfectious Anterior Scleritis
Authors: Elliott H. Sohn, Robert Wang, Russell Read, Athena Roufas, Livia Teo, Ramana Moorthy, Thomas Albini, Daniel V. Vasconcelos-Santos, Laurie D. Dustin, Ehud Zamir, Soon-Phaik Chee, Peter McCluskey, Ronald Smith, Narsing Rao
Journal: Ophthalmology (2011)