Calcium and Hypertension: The Emerging Connection
Authors: LAWRENCE M. RESNICK
Journal: Annals of Internal Medicine (1985)

Editorials1 December 1985Calcium and Hypertension: The Emerging ConnectionLAWRENCE M. RESNICK, M.D.LAWRENCE M. RESNICK, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-6-944 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince ringer first showed the importance of calcium in cardiac muscle contraction, a role for calcium has been increasingly recognized in mediating various cellular responses to external stimuli involved in neuromuscular function, stimulus-secretion coupling, and humoral target-organ effects. The use of calcium channel-blocking agents in the treatment of hypertension shows the critical importance of calcium in the biochemical control of vascular smooth muscle tone, and thus of blood pressure homeostasis.Despite these advances, the relation of clinical aspects of calcium metabolism such as dietary calcium intake, renal disposition of calcium, and circulating levels of calcium-regulating hormones, as well as of...References1. MCCARRONMORRIS DC. Blood pressure response to oral calcium in persons with mild to moderate hypertension: a randomized, double-blind, placebo-controlled, crossover trial. Ann Intern Med. 1985;103:825-31. LinkGoogle Scholar2. JOHNSONSMITHFREUDENHEIM NEJ. Effects on blood pressure of calcium supplementation of women. Am J Clin Nutr. 1985;42:12-7. CrossrefMedlineGoogle Scholar3. RESNICKSEALEYLARAGH LJJ. Short- and long-term oral calcium alters blood pressure (BP) in essential hypertension [Abstract]. Fed Proc. 1983;42:300. Google Scholar4. 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Alterations in calcium metabolism mediate dietary salt sensitivity in essential hypertension. Trans Assoc Am Physician. 1985. (In press). MedlineGoogle Scholar17. RESNICKNICHOLSONLARAGH LJJ. Calcium metabolism and the renin-aldosterone system in essential hypertension. J Cardiovas Pharm. 1985;7(suppl 6):S187-93. CrossrefMedlineGoogle Scholar18. RESNICKLARAGH LJ. Calcium regulating hormones and renin activity (PRA) are linked in human essential hypertension (EH) [Abstract]. In: IX International Congress of Nephrology. Thorofare, New Jersey: Slack Inc.; 1984:224A. Google Scholar19. RESNICKLARAGH LJ. Calcium metabolism and parathyroid function in primary aldosteronism. Am J Med. 1985;78:385-90. CrossrefMedlineGoogle Scholar20. LARAGHPECKER JM. Dietary sodium and essential hypertension: some myths, hopes and truths. Ann Intern Med. 1983;98:735-43. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The New York Hospital-Cornell University Medical Center New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOral Calcium Supplementation Reduces Intraplatelet Free Calcium Concentration and Insulin Resistance in Essential Hypertensive PatientsDietary calcium and blood pressure in experimental models of hypertension. 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