tbuckley/cabot-search huggingface dataset:
The Significance of the Serum Glutamic Oxalacetic Transaminase Activity Following Acute Myocardial Infarction
Authors: JOHN S. LADUE, FELIX WRÓBLEWSKI
Journal: Circulation (1955)

The serum glutamic oxalacetic transaminase rose two to 20 times normal in 74 of 75 patients who had acute transmural myocardial infarction. The height of the enzymatic activity was roughly proportional to the size of the infarct. Serum glutamic oxalacetic transaminase is unaffected by angina pectoris, coronary insufficiency, heart failure, or digitalis in the absence of active heart cell injury. Experimental myocardial infarction is followed consistently by a two to twenty-fold increase in serum glutamic oxalacetic transaminase activity. Increase in the serum activity of this enzyme appears to be a useful index of the presence of active heart muscle injury.
Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart.
Authors: R C Fentzke, C E Korcarz, R M Lang, H Lin, J M Leiden
Journal: Journal of Clinical Investigation (1998)

Idiopathic-dilated cardiomyopathy (IDC) is a common primary myocardial disease of unknown etiology characterized by progressive biventricular failure, cardiac dilatation, and premature mortality. Here we show that transgenic mice expressing a dominant-negative form of the CREB transcription factor (CREBA133) under the control of the cardiac myocyte-specific alpha-MHC promoter develop dilated cardiomyopathy that closely resembles many of the anatomical, physiological, and clinical features of human IDC. Between 2 and 20 wk of age, these mice develop four chamber cardiac dilatation, decreased systolic and diastolic left ventricular function, and attenuated contractile responses to the beta-adrenergic agonist, isoproterenol. Histologically, the CREBA133 hearts demonstrated both atrophic and hypertrophied fibers as well as significant interstitial fibrosis. These anatomical and hemodynamic changes were associated with hepatic congestion and peripheral edema, intracardiac thrombi, and premature mortality. Taken together, these results implicate CREB as an important regulator of cardiac myocyte function and provide a genetic model of dilated cardiomyopathy which should facilitate studies of both the pathogenesis and therapy of this clinically important disorder.
723-2 Selective Antagonism of Adenosine A 1 Receptor Mediated Effects in Humans with N-0861, (N 6 -Endonorboran-2-yl-9-Methyladenine)
Authors: Barry D. Bertolet, Elizabeth A. Franco, Richard A. Kerensky, Wilmer W. NiChols, Luiz Belardinelli, James A. Hill
Journal: Journal of the American College of Cardiology (1995)
Antisense oligonucleotides targeted against glucocorticoid receptor reduce hepatic glucose production and ameliorate hyperglycemia in diabetic mice
Authors: Yin Liang, Melville C. Osborne, Brett P. Monia, Sanjay Bhanot, Lynnetta M. Watts, Pengxiang She, Stephanie O. DeCarlo, Xiaoli Chen, Keith Demarest
Journal: Metabolism (2005)
Neo-vascularization and bone formation mediated by fetal mesenchymal stem cell tissue-engineered bone grafts in critical-size femoral defects
Authors: Zhi-Yong Zhang, Swee-Hin Teoh, Mark S.K. Chong, Eddy S.M. Lee, Lay-Geok Tan, Citra N. Mattar, Nicholas M. Fisk, Mahesh Choolani, Jerry Chan
Journal: Biomaterials (2009)
Treatment of multicentric Castleman's Disease accompanying multiple myeloma with bortezomib: a case report
Authors: Zhen-gang Yuan, Xiao-yi Dun, Yong-hua Li, Jian Hou
Journal: Journal of Hematology & Oncology (2009)

Abstract Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder of unknown etiology and characterized by various clinical manifestations and multiple organ involvement. It has been reported in association with POEMS syndrome and can progress to Kaposi's sarcoma or malignant lymphoma. The disease runs a more aggressive course and a poor prognosis. Optimal therapies have not been well established up to now. We here reported a case of rare MCD complicated with multiple myeloma who received bortezomib and achieved very good remission. To our knowledge, this is the first report on MCD in the setting of multiple myeloma with good response to bortezomib.
PREDICTORS OF LONG-TERM ADHERENCE TO EVIDENCE-BASED CARDIOVASCULAR DISEASE MEDICATIONS IN OUTPATIENTS WITH ATHEROTHROMBOTIC DISEASE
Authors: Fatima Rodriguez, Deepak Bhatt, Philippe Steg, Dharam Kumbhani, Amarachi Umez-Eronini, Elaine Hoffman, Christopher Cannon
Journal: Journal of the American College of Cardiology (2013)
Regulation of matrix metalloproteinase (MMP) expression in cutis laxa fibroblasts: upregulation of MMP‐1, MMP‐3 and MMP‐9 genes but not of the MMP‐2 gene
Authors: None Hatamochi, None Kuroda, None Shinkai, None Kohma, None Oishi, None Inoue
Journal: British Journal of Dermatology (1998)

A major histopathological abnormality in cutis laxa (CL) is a paucity of elastic structures. The aim of this study was to investigate the gene expression levels of the major matrix degrading factors matrix metalloproteinase (MMP) 1, MMP‐2, MMP‐3 and MMP‐9 in CL. The gene expression levels of MMP‐1, MMP‐2, MMP‐3 and MMP‐9 in cultured CL fibroblasts were measured by northern blot, immunoblot and gelatin zymographic analysis. Markedly increased mRNA levels of MMP‐1 (8.4‐fold), MMP‐3 (7.2‐fold) and MMP‐9 (more than 10‐fold) were found in CL fibroblasts, whereas MMP‐2 mRNA levels in these fibroblasts were unaltered. Increased protein production levels of MMP‐1 (4.6‐fold) and MMP‐3 (5.1‐fold) in CL fibroblasts were shown by immunoblot analysis. On gelatin zymographic analysis, the gelatinolytic activities of MMP‐9 but not of MMP‐2 were increased (2.2‐fold). These results suggest that increased gene expression levels of MMP‐1, MMP‐3 and MMP‐9 in CL fibroblasts may contribute to the histopathological abnormality in CL.
Improved accuracy of echocardiographic endocardial borders by spatiotemporal filtered Fourier reconstruction: description of the method and optimization of filter cutoffs.
Authors: J D Thomas, A A Hagege, C Y Choong, G T Wilkins, J B Newell, A E Weyman
Journal: Circulation (1988)

The usefulness of digitized echocardiographic borders in quantitative regional left ventricular function analysis has been limited by the wide reported range for normal wall motion with this technique. We postulated that random error in endocardial border positioning is a major cause of this limitation. To test this hypothesis, we traced the endocardial borders field by field from 17 complete echocardiographic cycles in six dogs. These cycles showed a great deal of random movement, with each endocardial point reversing its motion an average of 18.5 times per cardiac cycle. Spatiotemporal Fourier analysis of these sequences demonstrated that most of the valid information on endocardial motion was contained in the first four temporal harmonics and the first seven spatial harmonics and that beyond these points the Fourier transform has the spectral characteristics of noise. Reconstruction of these 17 cycles eliminating all Fourier components above the sixth temporal and eighth spatial harmonics reduced the mean number of endocardial reversals per cycle to 2.3 (p less than .00001). To derive the optimal temporal and spatial cutoffs, we compared reconstructions of each of the 17 cycles with three M mode echocardiograms obtained simultaneously with the cross-sectional images. Fourier cutoffs were varied between two and 20 harmonics and demonstrated that the optimal temporal cutoff was 5.5 harmonics and optimal spatial cutoff 6.9. With optimal filtering, the correlation between ventricular diameter derived from the M mode and from the cross-sectional images was r = .965, compared with .877 for the M mode vs unfiltered cross-sectional data (p less than .0001). We conclude that two-dimensional filtered Fourier reconstruction significantly improves the accuracy of traced echocardiographic borders. This technique should be useful in the postprocessing of endocardial borders extracted by automated edge detection schemes and should also be applicable to cardiac images derived from modalities other than echocardiography.
Treatment of chronic hepatitis C in HIV infected patients (PTS) with pegylated interferon alpha 2B (PEG-IFN) plus ribavirin (RBV) versus pegylated interferon alpha 2B
Authors: A. Cargnel, E. Angeli, A. Mainini, A. Casella, G. Gubertini, R. Giorgi, G. Orlando, P.G. Duca
Journal: Journal of Hepatology (2003)
1116-23 Noninvasive detection of angiogenesis with a technetium-99m labeled peptide targeted at αvβ3 integrin following hindlimb ischemia
Authors: Jing Hua, Brian N Bourke, James Song, Conroy Chow, Mehran M Sadeghi, Patti Cavaliere, Xiaoyue Hu, Neda Jahanshad, Lawrence W Dobrucki, Niels VanRoyen, Marivi Mendizabal, Ivo Buschmann, Albert J Sinusas
Journal: Journal of the American College of Cardiology (2004)
RETRO-PHARYNGEAL ABSCESS AND "HEN-CLUCK" STERTOR.
Authors: KENT K. WHEELOCK
Journal: JAMA (1889)

My apology for offering this oft-repeated tale to your readers is found in the fact that the basis of all true knowledge lies in observation and experience, and the further fact that the general practitioner, overworked, worried with waiting and watching the eventuation of a certain case, allows his mind to drift into a groove from which it is sometimes suddenly jerked by the rough jolt of death. And the further fact that the thinking mind, delicate as a galvanometer, takes cognizance of all externals calculated to make an impression upon it. On March 16 I was asked by the father of the child, the history of whose case I am about to relate, to meet my friend Dr. F. Greenwell, of Huntertown. I found a male child 11 months old, pale but well nourished, with a slight swelling on right side of upper part of neck in front of
IFNγ Promotes Papilloma Development by Up-regulating Th17-Associated Inflammation
Authors: Mingjie Xiao, Chunhui Wang, Jinhua Zhang, Zhiguang Li, Xueqiang Zhao, Zhihai Qin
Journal: Cancer Research (2009)

IFNgamma plays a crucial role in immunity against a variety of transplanted tumors and methylcholanthrene-mediated tumorigenesis in mice. However, it is not clear whether and how endogenous IFNgamma influences 7,12-dimethylbenz(a)anthracene (DMBA)-induced and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced papilloma development. We found here that IFNgamma expression was markedly up-regulated shortly after DMBA/TPA application to the skin. Surprisingly, neutralizing IFNgamma activity in vivo did not increase but rather decreased tumor development. Furthermore, IFNgamma receptor-deficient mice were also more resistant to papilloma development than their counterparts were. IFNgamma acted mainly in the promotion stage of papilloma development by enhancing TPA-induced leukocyte infiltration and epidermal hyperproliferation. The up-regulation of tumor necrosis factor alpha, interleukin (IL)-6, and transforming growth factor beta was largely dependent on host IFNgamma responsiveness. Remarkably, up-regulation of both IL-17 expression in the skin and T helper 17 (Th17) cell number in draining lymph nodes after DMBA/TPA treatment was dependent on IFNgamma signaling. Depletion of IL-17 not only decreased the DMBA/TPA-induced inflammation and keratinocyte proliferation but also delayed papilloma development. These results show that IFNgamma, under certain conditions, may promote tumor development by enhancing a Th17-associated inflammatory reaction.
The functional and pathologic relevance of autophagy proteases
Authors: Álvaro F. Fernández, Carlos López-Otín
Journal: Journal of Clinical Investigation (2015)

Autophagy is a well-conserved catabolic process essential for cellular homeostasis. First described in yeast as an adaptive response to starvation, this pathway is also present in higher eukaryotes, where it is triggered by stress signals such as damaged organelles or pathogen infection. Autophagy is characterized at the cellular level by the engulfment of portions of the cytoplasm in double-membrane structures called autophagosomes. Autophagosomes fuse with lysosomes, resulting in degradation of the inner autophagosomal membrane and luminal content. This process is coordinated by complex molecular systems, including the ATG8 ubiquitin-like conjugation system and the ATG4 cysteine proteases, which are implicated in the formation, elongation, and fusion of these autophagic vesicles. In this Review, we focus on the diverse functional roles of the autophagins, a protease family formed by the four mammalian orthologs of yeast Atg4. We also address the dysfunctional expression of these proteases in several pathologic conditions such as cancer and inflammation and discuss potential therapies based on their modulation.
Christopher Paul Varty
Authors: J. Varty
Journal: BMJ (2009)

<h3>Abstract</h3> <h3>Background and Aims</h3> Diurnal changes in solar position and intensity combined with the structural complexity of plant architecture result in highly variable and dynamic light patterns within the plant canopy. This affects productivity through the complex ways that photosynthesis responds to changes in light intensity. Current methods to characterise light dynamics, such as ray-tracing, are able to produce data with excellent spatio-temporal resolution but are computationally intensive and the resultant data are complex and high dimensional. This necessitates development of more economical models for summarising the data and for simulating realistic light patterns over the course of a day. <h3>Methods</h3> High-resolution reconstructions of field-grown plants are assembled in various configurations to form canopies, and a forward ray-tracing algorithm is applied to the canopies to compute light dynamics at high (1 minute) temporal resolution. From the ray-tracer output, the sunlit or shaded state for each patch on the plants is determined, and these data are used to develop a novel stochastic model for the sunlit-shaded patterns. The model is designed to be straightforward to fit to data using maximum likelihood estimation, and fast to simulate from. <h3>Key Results</h3> For a wide range of contrasting 3D canopies, the stochastic model is able to summarise, and replicate in simulations, key features of the light dynamics. When light patterns simulated from the stochastic model are used as input to a model of photoinhibition, the predicted reduction in carbon gain is similar to that from calculations based on the (extremely costly) ray-tracer data. <h3>Conclusions</h3> The model provides a way to summarise highly complex data in a small number of parameters, and a cost-effective way to simulate realistic light patterns. Simulations from the model will be particularly useful for feeding into larger-scale photosynthesis models for calculating how light dynamics affects the photosynthetic productivity of canopies.
How good is general practice developmental screening?
Authors: J Dearlove, D Kearney
Journal: BMJ (1990)

All developmental screening in Somerset is performed by general practitioners and health visitors. A retrospective review of a cohort of 1504 7 year old children living in semirural Somerset found that the development assessment by a health visitor at age 3 1/2 years had a sensitivity of 45% for identifying the 103 children with special educational needs, whereas the sensitivity of the preschool examination by a general practitioner was 56%. There was no relation between results of preschool developmental assessment and later reading ability. Of the 23 children in special schools, 22 had been identified independently of the developmental screening programme before starting school. Intervention was started at a mean age of 1 year 5 months (range 2 months to 3 years) for children with severe learning difficulties, and 3 years 9 months (2 years 3 months to 6 years 6 months) for children with moderate learning difficulties. The preschool medical examination revealed fairly minor medical problems: 29 of 81 children referred for specialist opinions were shown to be medically normal, and for only seven of the medically abnormal children was information about their conditions given to their teachers. In Somerset screening the development of all children at predetermined ages has not been very useful.
TCT-721 P2Y12 Reactivity units (PRU) to Predict Hyporesponsiveness to Clopidogrel in Patients with Chest Pain with Prior History of Coronary Artery Stenting in Emergency Department
Authors: Rakesh Sharma, Stephen Erickson, Rohit Sharma, Hanumanth Reddy, Donald Voelker, Harvinder Dod, Vibhuti Singh, james Marsh
Journal: Journal of the American College of Cardiology (2012)
Pentavalent Technetium-99m DMSA Uptake in Pseudofractures of Osteomalacia
Authors: MURATHAN SAHIN, TARIK BASOGLU, SELAHATTIN ALBAYRAK, FEVZIYE CANBAZ, OKTAY YAPICI
Journal: Clinical Nuclear Medicine (2001)

Tc-99m MDP and Tc-99m (V) DMSA images are described from a 49-year-old woman with chronic renal insufficiency complicated by osteomalacia. Clinical, biochemical, and radiologic bone profiles were compatible with osteomalacia. Osteomalacia is a condition associated with disorders in which mineralization of the organic matrix is defective. All bone lesions visualized with Tc-99m MDP also showed increased uptake of Tc-99m (V) DMSA. Tc-99m (V) DMSA accumulation has been reported in many malignant and some benign conditions. Pseudofractures in osteomalacia could be included in the spectrum of benign lesions that accumulate Tc-99m (V) DMSA.
Involvement of neutrophils in postischaemic damage to the small intestine.
Authors: M H Schoenberg, B Poch, M Younes, A Schwarz, K Baczako, C Lundberg, U Haglund, H G Beger
Journal: Gut (1991)

Haemorrhagic mucosal lesions are produced during intestinal ischaemia and after reperfusion probably mediated by oxygen radicals. Oxygen radicals react with cell membrane lipids and induce cell damage by peroxidation and induce accumulation of polymorphonuclear leucocytes in the tissue. The aim of the study was to elucidate the involvement of polymorphonuclear leucocytes in post-ischaemic intestinal damage. Intestinal ischaemia was induced in cats by partial occlusion of the superior mesenteric artery. Samples from the small intestine were excised before and at the end of the two hour hypotensive period as well as 10 minutes and 60 minutes after reperfusion. Conjugated dienes, myeloperoxidase, and the purine metabolites were determined in the samples. The tissue was also examined histologically. Seven cats were treated before reperfusion with a monoclonal antibody (IB4) which inhibits leucocyte adherence to endothelial cells and its subsequent activation. After reperfusion myeloperoxidase activity increased and the ischaemic mucosal lesions worsened significantly. IB4 treatment prevented an increase in post-hypotensive myeloperoxidase activity and attenuated the normally observed severe mucosal lesions. We conclude that the severe post-ischaemic lesions are induced by polymorphonuclear leucocytes. Such mucosal injury may be appreciably reduced by blocking leucocyte adherence with IB4.
Abstract 4786: Circulating miR-21, miR-146a and miR-210 levels in plasma are associated with clinical outcome in breast cancer
Authors: Ioanna S. Sourvinou, Athina Markou, Nikolaos Malamos, Vasilis Georgoulias, Εvi S. Lianidou
Journal: Cancer Research (2014)

Abstract Introduction: The discovery of novel non-invasive tumor biomarkers for early diagnosis, prognosis and therapy monitoring remains an undeniable imperative necessity. Circulating miRNAs have recently attracted a lot of interest as novel promising tumor biomarkers. In the present study, we investigated the expression levels of three cancer-associated miRNAs in plasma and evaluated their prognostic significance in breast cancer. Materials and Methods: We examined the expression levels of miR-21, miR-146a and miR-210 in plasma samples of 134 breast cancer patients (57 patients with verified metastasis and 77 patients with operable breast cancer) and 20 healthy individuals. Circulating miRNAs were isolated from 200μL of plasma using mirVana PARIS kit and in each sample 25fmol of the synthetic cel-miR-39 were spiked as exogenous control. For the quantification of plasma miRNAs, a stem-loop cDNA approach and TaqMan real time PCR (LightCycler 2, Roche Applied Science) were used. The normalization procedure was based on a combination of cel-miR-39 as exogenous control and hsa-miR-191 as endogenous control. Relative expression of circulating miRNAs in plasma was evaluated as previously described (Sourvinou et al., J. of Mol. Diagn, 2013). Results: Our results indicate that the expression levels of all three circulating miRNAs are significantly increased in plasma both in operable and metastasis verified breast cancer patients in comparison to those of healthy individuals (p&amp;lt;0.001). The expression levels of plasma miR-210 are slightly increased in patients with operable breast cancer in respect to patients with verified metastasis (p=0.034). In patients with verified metastasis, Kaplan-Meier survival analysis demonstrated an association between elevated levels of plasma miR-21 and overall survival (OS) (p= 0.001) and there was a trend with disease-free interval (DFI) (p=0.053). Concerning miR-146a, increased plasma expression levels were correlated with short OS (p=0.029), but there was no correlation with DFI (p=0.914). Finally, respecting miR-210, Kaplan-Meier survival analysis did not show any association with OS or DFI of these patients. Conclusions: Our results indicate that quantification of circulating miR-21 and miR-146a in plasma are promising prognostic biomarkers in breast cancer and should be further evaluated in a large number of patients. Citation Format: Ioanna S. Sourvinou, Athina Markou, Nikolaos Malamos, Vasilis Georgoulias, Εvi S. Lianidou. Circulating miR-21, miR-146a and miR-210 levels in plasma are associated with clinical outcome in breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4786. doi:10.1158/1538-7445.AM2014-4786
Grass pollen immunotherapy: A single year double-blind, placebo-controlled study in patients with grass pollen-induced asthma and rhinitis
Authors: Claudio Ortolani, Elide Pastorello, Richard B. Moss, Yao-Pi Hsu, Massimo Restuccia, Giovanni Joppolo, Antonio Miadonna, Umberto Cornelli, Georges Halpern, Carlo Zanussi
Journal: Journal of Allergy and Clinical Immunology (1984)
The Magnesium-Deficiency Tetany Syndrome in Man
Authors: Bert L. Vallee, Warren E. C. Wacker, David D. Ulmer
Journal: New England Journal of Medicine (1960)

MAGNESIUM is second only to potassium in abundance as an intracellular cation. The whole body of a human adult contains nearly 25 gm.1 The numerous important biochemical reactions dependent upon the presence of this metal have been discussed elsewhere.2 Magnesium is an essential nutrient for animals and plants, suggesting that a dietary inadequacy of this ion might readily result in deficiency disease. Indeed, such deficiency states have been induced in animals. Tetany and convulsions, subsequent to experimental magnesium deficiency, were first shown to occur in rats, in 1932,3 and later in many other animal species.4 5 6 Spontaneous magnesium-deficiency tetany has been . . .