Methicillin-Associated Thrombocytopenia
Authors: CHARLES A. SCHIFFER
Journal: Annals of Internal Medicine (1976)

Letters1 September 1976Methicillin-Associated ThrombocytopeniaCHARLES A. SCHIFFER, M.D., HOWARD J. WEINSTEIN, M.D., PETER H. WIERNIK, M.D.CHARLES A. SCHIFFER, M.D.Search for more papers by this author, HOWARD J. WEINSTEIN, M.D.Search for more papers by this author, PETER H. WIERNIK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-3-338 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThrombocytopenia in patients with leukemia is usually due to marrow involvement with malignant blasts or to the effects of chemotherapy. Failure to achieve count increments after platelet transfusion is usually caused by recipient alloimmunization in the absence of organomegaly, infection, or consumption coagulopathy. In the case presented below, immune thrombocytopenia caused by methicillin (Staphcillin⌖; Bristol Laboratories; Syracuse, New York) complicated the clinical course of a patient with leukemia.A 41-year-old woman was referred to the Baltimore Cancer Research Center (BCRC) for the therapy of acute lymphoblastic leukemia. She had been in excellent health until about 1 month before admission, when she...References1. ASTER R: Detection of anti-platelet antibodies: inhibition of clot retraction, in Hematology, edited by WILLIAMS WJ, BEUTLER E. ERSLEV AJ, et al: New York, McGraw-Hill Book Co., 1972, pp. 1417-1419 Google Scholar2. HOROWITZRAPPAPORTYOUNG HHR: Change in platelet factor-3 as a means of demonstrating immune reactions involving platelets: its use as a test for quinidine-induced thrombocytopenia. Transfusion 5:336-343, 1965 CrossrefMedlineGoogle Scholar3. DEYKINHELLERSTEIN DL: The assessment of drug dependent and isoimmune anti-platelet antibodies by the use of platelet aggregometry. J Clin Invest 51:3142-3153, 1972 CrossrefMedlineGoogle Scholar4. HSIKUOOUYANG YHA: Thrombocytopenia following administration of penicillin. Report of a case. Chin Med J 85: 249-251, 1966 MedlineGoogle Scholar5. DUQUESNOYLORENTZENASTER RDR: Platelet migration inhibition: a new method for detection of platelet antibodies. Blood 45:741-747, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHARLES A. SCHIFFER, M.D.; HOWARD J. WEINSTEIN, M.D.; PETER H. WIERNIK, M.D.Affiliations: Section of Medical Oncology National Cancer Institute Baltimore Cancer Research Center at the University of Maryland Hospital 22 South Greene Street Baltimore, MD 21201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPenicillinsAdverse reactions to β-lactam antimicrobialsANTIBACTERIAL DRUGSPenicillinsHematologic effects of linezolid in young childrenInefficacité des transfusions de plaquettes au cours des thrombopénies d'origine centraleMacrogolThrombocytopenia in the critically ill patientEffect of Antibiotics on Colony Formation from Mouse Granulocyte-Macrophage Progenitors (CFU-GM), Megakaryocyte Progenitors (CFU-M) and Erythrocyte Progenitors (CFU-E, BFU-E) in VitroSuppressive Effect of Antibiotics on Colony Formation from Human Megakaryocyte Progenitors (CFU-M) and Granulocyte-Macrophage Progenitors (CFU-GM)Suppressive Effect of Antibiotics on Colony Formation from Human Megakaryocyte Progenitors (CFU-M) and Granulocyte-Macrophage Progenitors (CFU-GM)Toxicology of β-Lactam AntibioticsPlatelet TherapyDrug-induced ThrombocytopeniaAntimicrobial Agents in Pulmonary InfectionsClinical and pharmacokinetic evaluation of nafcillin in infants and childrenPenicillins, cephalosporins and tetracyclinesPlatelet Transfusion Therapy 1 September 1976Volume 85, Issue 3Page: 338-339KeywordsBone marrowChemotherapyDisseminated intravascular coagulationIdiopathic thrombocytopenic purpuraPlateletsPrecursor cells ePublished: 1 December 2008 Issue Published: 1 September 1976 PDF downloadLoading ...