tbuckley/cabot-search huggingface dataset:
Synacthen depot used in general practice.
Authors: J. E. Murphy, J. F. Donald
Journal: BMJ (1969)

tions are seldom encountered even with the most energetic infusions.Also in a series .of 84adults to be published shortly' the patients commonly had large fluid deficits and several litres of fluid had to be infused before urine flow became established.As demonstrated in the case report of Dr. Savege and his colleagues, an increased urine flow is an important factor in salicylate clearance.In some patients, therefore, a rapid infusion rate is mandatory.Drs. Morgan and Polak also claim that their regimen is free from important complications, but this is perhaps hardly justified, as six of their ten patients developed capil- lary pH values in excess of 7 5, and although all the serum potassium levels were normal at the outset eight developed significant hypo- kalaemia with a potentially dangerous level in five.As these changes occurred rapidly, it seems likely that considerable acid-base changes with associated electrolyte shifts were taking place.These findings are similar to those encountered with the early regimens of forced alkaline diuresis described by Cumming and his colleagues in 1964.2Treatment with bicarbonate and acetazola- mide, therefore, still requires very careful laboratory control and in its present form, is less safe than the newer modifications of the Cumming's regimen referred to in your leading article (January 4, p. 3).-I am, etc.,
Left Ventricular Performance During Mild Supine Leg Exercise in Coronary Artery Disease
Authors: BEN D. MCCALLISTER, TADA YIPINTSOI, FRANZ J. HALLERMANN, ROBERT B. WALLACE, ROBERT L. FRYE
Journal: Circulation (1968)

Left ventricular (LV) performance was studied during mild exercise (100 kg-m/min for 3 minutes) in 19 cases of coronary artery disease (CAD). Each patient suffered from a severe anginal syndrome. None had ventricular aneurysm, cardiomegaly, or clinical heart failure. Mean resting values follow: LV end-diastolic pressure (LVEDP), 19 ± 7 mm Hg; LV systolic pressure (LVSP), 150 ± 16 mm Hg; stroke volume index (SVI), 48 ± 10 ml/beat/m 2 ; and LV stroke work index (LVSWI), 81 ± 19 g-m/m 2 . During exercise LVEDP rose to 30 ± 8 mm Hg ( P ≤0.001) and LVS to 160 ± 20 (not significant [NS]); SVI diminished to 46 ± 11 (NS) and LVSWI, to 76 ± 24 (NS). Patients with decreased or asynchronous areas of LV myocardium identified on cine left ventriculograms had higher mean LVEDPs during exercise than did those with normal ventriculograms (34 ± 10 versus 26 ± 4 mm Hg; P ≤0.05). The difference between responses to exercise of patients who experienced angina during the study and of those who did not was NS. Administration of nitroglycerin reduced the increase in LVEDP during exercise. An abnormality in LV performance-a significant rise in LVEDP without a significant increase in SVI or LVSWI-was observed in 13 of 19 cases of CAD.
Abstract 3568: Treatment of Organ-Specific Chloroleukemia by Cytotech Labs API 31510 and Chemotherapy
Authors: Niven R. Narain, Lucia M. Mauro, John P. McCook, Joaquin J. Jimenez
Journal: Cancer Research (2010)

Abstract The development of chloroleukemia in the rat after transplantation leads to 100% mortality. Recently, two novel clones have been developed. Following intraperitoneal injection, one clone preferentially migrates and forms tumors in the lungs (CHL-L), while another clone forms tumors in the liver (CHL-Li). In vitro, proliferation of both clones were inhibited in a dose-dependent manner by a novel IV solution of API 31510. Accordingly, in the present study we examined the hypothesis that Cytotech Labs API 31510 alone or in combination with cyclophosphamide (CTX) could be effective in the treatment of both clones in vivo. In the first experiments, 24 rats were randomized into 4 groups of six rats each and injected intraperitoneally with CHL-L. In the control group, 100% developed CHL-L. In the group receiving CTX, 5 out of 6 developed CHL-L, while 1 animal remained disease-free. In the group receiving API 31510, 3 out of 6 rats remained disease-free and 3 out of 6 had a partial therapeutic response. In the group which received API 31510 and CTX, 100% of the animals remained disease-free. In a separate experiment, the same protocol was followed using CHL-Li. As observed with the other clone, animals injected with all control animals developed CHL-Li tumors. Similarly, in the group receiving CTX alone, 5 out of 6 developed CHL-Li and 1 remained disease-free. In the group receiving API 31510, 3 out of 6 animals remained disease-free and 3 out of 6 had a partial response. When combining 31510 and CTX, 5 out of 6 animals remained disease-free and 1 had a partial response. No side effects were observed in the animals receiving API 31510 as evidenced by weight gain and behavior. Taken together, these results indicate that API 31510 as a single agent was effective against both chloroma clones used and as an adjuvant to chemotherapy, API 31510 exhibited treatment efficacy in over 90% of animals treated. These data provide a strong foundation for further development of Cytotech Labs API 31510 intravenous formulation as a viable agent for cancer. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3568.
The optimization of porous polymeric scaffolds for chondrocyte/atelocollagen based tissue-engineered cartilage
Authors: Yoko Tanaka, Hisayo Yamaoka, Satoru Nishizawa, Satoru Nagata, Toru Ogasawara, Yukiyo Asawa, Yuko Fujihara, Tsuyoshi Takato, Kazuto Hoshi
Journal: Biomaterials (2010)
THE VIRILE AND OTHER NERVOUS REFLEXES.Read before the Section of Medical Jurisprudence and Neurology, at the Forty-second Annual Meeting of the American Medical Association, held at Washington, D. C., May, 1891.
Authors: C. H. HUGHES
Journal: JAMA (1891)

In a previous communication on this subject (<i>vide Alienist and Neurologist</i>for January, 1891), I have called attention to the fact that in a perfectly healthy individual, whose spinal cord is entirely normal, especially in its genitospinal center, placed supine on a couch without headrest, nude about the loins, the sheath of the penis made tense by clasping the foreskin with the left index finger and thumb at about the place of the frænum, and pulling it firmly toward the umbilicus, placing the middle, ring and little finger low down upon the dorsum of the virile organ, the dorsum or sides of the penis, near the perineal extremity, then sharply precussed, a quick and very sensible reflex motor response or retraction of the bulbo-cavernous portion will be felt to result from this sudden percussional impression, like that which follows, though less pronounced, in the testicles, after sensory irritation of the
Five years after baby Peter
Authors: D. Spence
Journal: BMJ (2012)

Safeguarding children from physical, emotional, and sexual abuse is a fundamental duty. It is now five years since baby Peter Connelly’s death and 12 years since that of Victoria Climbie. These deaths highlight the weakness in child protection. Worthy and wordy reports have come from Lord Laming and Professor Munro, and advice is pending from the GMC. Investigations long on generalisations but short on any specifics. The doctors and nurses working in frontline general practice do so for decades and have an unmatched knowledge of families. So from our view, …
Dual Ectopic Thyroid Gland
Authors: Vinko Marković, Gordana Glavina, Davor Eterović, Ante Punda, Dubravka Brdar
Journal: Clinical Nuclear Medicine (2014)

Dual ectopic lingual and sublingual thyroid gland is an extraordinarily rare condition. We present 1 patient with subclinical hypothyroidism. The clinical examination revealed that the thyroid gland was not palpable in its usual cervical location, whereas ultrasonography confirmed an empty thyroid bed without any ectopic thyroid tissue in the rest of the neck. The final diagnosis of dual ectopic lingual and sublingual thyroid was established by ultrasound examination through the mouth floor and confirmed by scintigraphy and CT thereafter.
Deleterious impact of <i>Pseudomonas aeruginosa</i> on cystic fibrosis transmembrane conductance regulator function and rescue in airway epithelial cells
Authors: Nguyen Thu Ngan Trinh, Claudia Bilodeau, Émilie Maillé, Manon Ruffin, Marie-Claude Quintal, Martin-Yvon Desrosiers, Simon Rousseau, Emmanuelle Brochiero
Journal: European Respiratory Journal (2015)

The epithelial response to bacterial airway infection, a common feature of lung diseases such as chronic obstructive pulmonary disease and cystic fibrosis, has been extensively studied. However, its impact on cystic fibrosis transmembrane conductance regulator (CFTR) channel function is not clearly defined. Our aims were, therefore, to evaluate the effect of Pseudomonas aeruginosa on CFTR function and expression in non-cystic fibrosis airway epithelial cells, and to investigate its impact on ΔF508-CFTR rescue by the VRT-325 corrector in cystic fibrosis cells. CFTR expression/maturation was evaluated by immunoblotting and its function by short-circuit current measurements. A 24-h exposure to P. aeruginosa diffusible material (PsaDM) reduced CFTR currents as well as total and membrane protein expression of the wildtype (wt) CFTR protein in CFBE-wt cells. In CFBE-ΔF508 cells, PsaDM severely reduced CFTR maturation and current rescue induced by VRT-325. We also confirmed a deleterious impact of PsaDM on wt-CFTR currents in non-cystic fibrosis primary airway cells as well as on the rescue of ΔF508-CFTR function induced by VRT-325 in primary cystic fibrosis cells. These findings show that CFTR function could be impaired in non-cystic fibrosis patients infected by P. aeruginosa. Our data also suggest that CFTR corrector efficiency may be affected by infectious components, which should be taken into account in screening assays of correctors.
Tuberculosis in a changing world
Authors: N Stoker
Journal: BMJ (1994)

The reversal in the decline of tuberculosis during the past few years has been widely publicised. The World Health Organisation has declared a global emergency in the light of the rising incidence of the disease in developing countries, where the interaction between tuberculosis and AIDS can be devastating. In Zambia, for example, two thirds of patients who are diagnosed as having tuberculosis are HIV positive.1 But the problem is not confined to developing countries. In some American cities rates have risen alarmingly and strains resistant to multiple antibiotics have emerged.2 Notifications of tuberculosis have also risen in Britain since 1987, with drug resistant isolates increasing from 8% in 1987 to 14% in 1991.3 How should we respond to this re-emerging threat? The answer will differ among countries, but an understanding of the factors affecting transmission of the pathogen is crucial.

The recent development of molecular typing for Mycobacterium tuberculosis allows us to track the spread of individual …
Plasma biomarkers of acute attacks in patients with angioedema due to C1‐inhibitor deficiency
Authors: M. Cugno, A. Zanichelli, A. G. Bellatorre, S. Griffini, M. Cicardi
Journal: Allergy (2008)

Cl-inhibitor (C1-INH) deficiency leads to recurrent attacks of mucocutaneous edema and may be inherited (hereditary angioedema [HAE]) or acquired (acquired angioedema [AAE]), which have the same clinical picture characterized by angioedema involving the skin, gastrointestinal tract, and larynx. Although cutaneous swelling is evident, abdominal angioedema is still a diagnostic challenge and attacks can mimic surgical emergencies. There is currently no laboratory marker for identifying angioedema attacks.As coagulation and fibrinolysis are activated during angioedema attacks, we assessed if plasma measurements of prothrombin fragment F1 + 2 (marker of thrombin generation) and D-dimer (marker of fibrin degradation) can be useful for the diagnosis of angioedema because of C1-INH deficiency, especially in case of hidden locations as abdominal attacks.In addition to complement, we measured plasma levels of F1 + 2 and D-dimer in 28 patients with C1-INH deficiency during acute attacks and remission, 35 patients without C1-INH deficiency during abdominal colics, and 20 healthy subjects.Plasma F1 + 2 levels were higher in patients with C1-INH deficiency during remission than in healthy controls (P = 0.001), and further increased during cutaneous and abdominal attacks (P = 0.0001); patients without C1-INH deficiency had normal F1 + 2 levels during abdominal colics. Plasma D-dimer levels were higher in patients with C1-INH deficiency during remission than in controls (P = 0.012) and increased during angioedema attacks, reaching higher levels than in patients without C1-INH deficiency during colics (P = 0.002).During acute angioedema attacks, patients with C1-INH deficiency have high prothrombin fragment F1 + 2 and D-dimer levels, the measurement of which may have an important diagnostic value.
Cholesterol and Coronary Heart Disease
Authors: Scott M. Grundy
Journal: JAMA (1990)

The importance of high serum cholesterol levels as a risk factor for coronary heart disease and the benefit of lowering cholesterol levels for reducing risk are being increasingly accepted. A broad consensus to this effect has led to the establishment of the National Cholesterol Education Program. Although the available evidence fully justifies this program, its practical application to the American public has generated a series of new questions that must be explored. For example, it can be questioned whether reduction in coronary risk through lowering cholesterol levels extends to both sexes and all age groups. For people with high cholesterol levels, dietary modification is undoubtedly the first step of management, but the fraction of people responding adequately to dietary change remains to be determined. Finally, indications for drug therapy and choice of drugs need further exploration, particularly in the area of cost vs benefit. Thus, continuing research must be carried out in parallel with clinical and public health application of cholesterol education. (<i>JAMA</i>. 1990;264:3053-3059)
Abstract 1459: Detection of EpCAM negative circulating tumor cells in CellSearch waste.
Authors: Guus van Dalum, Aufried T.M. Lenferink, Leon W.M.M. Terstappen
Journal: Cancer Research (2013)

Abstract Introduction: Circulating tumor cells (CTC) measured with the CellSearch system in patients with metastatic carcinomas are associated with poor survival. The CellSearch system uses immunomagnetic enrichment targeting the EpCAM antigen. A frequently raised question is what the frequency and significance is of CTC that do not express EpCAM within the CTC of the individual patient and between different patients. To investigate this, a device was constructed that collects the blood discarded by the CellSearch system and passes the blood through micro sieves with 5um pores to enrich for the larger CTC. Methods: A sample collection device was attached to the waste line of the CellTracks Autoprep (AP). The blood discarded after immunomagnetic separation was detected in the waste line and collected into a separate 50ml conical tube for each patient sample. After collection, the blood was filtered through microfabricated silicon nitride filters with pore diameters of 5 micrometer (Aquamarijn, Zutphen, The Netherlands) with a pressure below 40mbar. To evaluate recovery on the filter the COLO320(median size 11μm), SKBR3(16μm) and T24(16μm) cell lines where used. To evaluate recovery from the AP waste the SKBR3(445000 EpCAM antigens) and T24(2167 EpCAM antigens) cell lines where used. 300 cells where spiked in 7.5ml of blood collected in CellSave tubes from healthy volunteers. All samples were processed the day after collection. Results: The average recovery on filter from whole blood is 29% for COLO320 and ≥80% for SKBR3 and T24. The average recovery of the SKBR3 cell line with the CellSearch system is 91% and 5% are recovered from the AP waste using filtration. In contrast, the average recovery of T24 cell line with the CellSearch system is only 30% but 51% are recovered from the AP waste after filtration. The carryover between spiked and unspiked samples collected from the AP waste was &amp;lt;1.3% of the spiked cells for unspiked samples with a mean of 0.9%. Conclusions: We present a method and device that enables the identification and characterization of CTC not detected by the CellSearch system which allows a systematic evaluation of the clinical relevance of these CTC. Citation Format: Guus van Dalum, Aufried T.M. Lenferink, Leon W.M.M. Terstappen. Detection of EpCAM negative circulating tumor cells in CellSearch waste. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1459. doi:10.1158/1538-7445.AM2013-1459
Lymphocytic Interstitial Pneumonitis and Other Immunologic Disorders
Authors: DAVID STEINBERG
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 December 1978Lymphocytic Interstitial Pneumonitis and Other Immunologic DisordersDAVID STEINBERG, M.D., JOSEPH L. ANDREWS JR., M.D.DAVID STEINBERG, M.D.Search for more papers by this author, JOSEPH L. ANDREWS JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-6-1011_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Lymphocytic interstitial pneumonitis may be another example of the overlapping spectrum of benign lymphoid proliferation, malignant lymphoma, and autoimmune disease. Disorders likely to be autoimmune that have been described (1) with lymphocytic interstitial pneumonitis include myasthenia gravis, pernicious anemia, Sjögren's syndrome, autoerythrocyte sensitization, and chronic active hepatitis. We supplement this list by describing the case of a patient with lymphocytic interstitial pneumonitis who had autoimmune hemolytic anemia, probable autoimmune neutropenia and thrombocytopenia, and perhaps autoimmune liver and thyroid disease.A 34-year-old man was admitted to the New England Deaconess Hospital in July 1976 because of peripheral lymphadenopathy,...Reference1. STRIMLANROSENOWWEILANDBROWN CELL: Lymphocytic interstitial pneumonitis. Review of 13 cases. Ann Intern Med 88:616-621, 1978 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New England Deaconess Hospital Boston, MA 02215 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1978Volume 89, Issue 6Page: 1011-1011KeywordsAutoimmune diseasesAutoimmune hepatitisHemolytic anemiaInterstitial lung diseasesLiver diseasesLymphomaMyasthenia gravisNeutropeniaPernicious anemiaThyroid diseases Issue Published: 1 December 1978 PDF DownloadLoading ...
Global Climate Change and Health: Challenges for Future Practitioners
Authors: Jonathan A. Patz, Mahmooda Khaliq
Journal: JAMA (2002)

OVERVIEW Global climate change is expected to have broad health impacts. If current warming trends continue, heat waves, floods, and droughts and their attendant physical effects are likely to become more frequent and severe. Warmer air temperatures can influence the concentration of regional air pollutants and aeroallergens. Less direct health impacts may result from the disruption of ecosystems and of water and food supplies, which in turn could affect infectious disease incidence and nutritional status. Finally, sea-level rise could lead to major population displacement and economic disruption.
HIV Vaccine Concerns?
Authors: Joan Stephenson
Journal: JAMA (2007)

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Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases
Authors: Rory R. Koenen, Jessica Pruessmeyer, Oliver Soehnlein, Line Fraemohs, Alma Zernecke, Nicole Schwarz, Karina Reiss, Alisina Sarabi, Lennart Lindbom, Tilman M. Hackeng, Christian Weber, Andreas Ludwig
Journal: Blood (2009)