tbuckley/cabot-search huggingface dataset:
Intestinal Angina
Authors: William P. Mikkelsen, John A. Zaro
Journal: New England Journal of Medicine (1959)

EARNEST attention is currently being focused upon intestinal angina, a syndrome that may precede the acute abdominal catastrophe of irreversible ischemic bowel infarction.1 2 3 4 5 6 7 8 9 10 At this terminal, critical stage the death of the patient is usually inevitable.11 12 13 14 A review of the American literature suggests that this prodrome has been suspected during the life of the patient in only 2 recorded cases.1 , 2 In each of these cases, the conclusive diagnosis was established only during emergency surgery that was being carried out for bowel infarction. The clinical picture, the pathologic process involved and the potential for surgical cure in intestinal angina have only . . .
A cis-Element in the 5′ Untranslated Region of the Preproinsulin mRNA (ppIGE) Is Required for Glucose Regulation of Proinsulin Translation
Authors: Barton Wicksteed, Yuji Uchizono, Cristina Alarcon, Jill F. McCuaig, Anath Shalev, Christopher J. Rhodes
Journal: Cell Metabolism (2007)
Usefulness of high-dose dipyridamole echocardiography test in coronary angioplasty.
Authors: E Picano, S Pirelli, M Marzilli, F Faletra, F Lattanzi, L Campolo, D Massa, A Alberti, E Gara, A Distante
Journal: Circulation (1989)

Seventy-four consecutive patients with angina undergoing single-lesion percutaneous transluminal coronary angioplasty were evaluated with high-dose (up to 0.84 mg/kg during 10 minutes) dipyridamole echocardiography test (DET) before angioplasty and when possible, afterward. Angioplasty was clinically or angiographically successful in 63 patients and unsuccessful in 11. Before the procedure, 69 patients had a positive DET. Of these 69 patients, six with clinicall unsuccessful angioplasty had a dipyridamole time (i.e., the time from the onset of dipyridamole infusion to development of asynergy) lower than the 63 patients with clinically successfully angioplasty (4.2 +/- 2.9 vs. 7.0 +/- 2.9 minutes, mean +/- SD, p less than 0.01). In the five patients with angiographically unsuccessful angioplasty (residual stenosis diameter, greater than 50%), coronary stenosis decreased from 89 +/- 10 to 69 +/- 22 (p = NS); DET was positive in all five before and in four of the five after the procedure (100% vs. 80%, p = NS). In the 63 patients with angiographically successful angioplasty, coronary stenosis diameter was reduced from 85 +/- 9% to 30 +/- 10% (p less than 0.01). DET was positive in 58 patients before and in only 16 after the procedure (92% vs. 25%, p less than 0.01). In the 16 patients with positive DET, before and after angioplasty, dipyridamole time increased from 5.6 +/- 2.2 before to 7.3 +/- 2.4 minutes immediately after the procedure (p less than 0.05). After an average follow-up time of 10.8 +/- 5.9 months, angina recurred in eight of 47 patients with negative DET after angioplasty and in 11 of 16 patients with positive DET (17% vs. 69%, p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
TRANSRADIAL VERSUS TRANSFEMORAL INTERVENTION IN ACUTE MYOCARDIAL INFARCTION PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION IN ASIAN POPULATION
Authors: Seung Woon Rha, Ji Young Park, Byoung Geol Choi, Cheol Ung Choi, Dong Joo Oh, Byung Ryul Cho, Moo Hyun Kim, Doo-Il Kim, Myung-Ho Jeong, Sang Yong Yoo, Sang-Sik Jeong, Byung Ok Kim, Min Su Hyun, Junghan Yoon
Journal: Journal of the American College of Cardiology (2011)
Human and Bovine Tuberculosis.
Authors: George D. Barney
Journal: JAMA (1902)

Brooklyn, N. Y., Jan. 6, 1902. <h3>To the Editor:</h3> —Your editorial entitled "Human and Bovine Tuberculosis," published in your issue of the 4th inst., contains so many errors that it is surprising that it should appear in the columns of a reputable journal. May I inquire how you know that the "experiment was poorly conceived" and "lacked many of the essentials for a satisfactory scientific proof of what it was intended to show"? Your only authority must have been the daily press, to the representatives of which I declined to give the details for the reason that I did not desire the publicity it would entail before the test was finished. As usual, the story was made up from meager information largely obtained from hearsay, and it went out as coming from me. Had you wished to know the truth of the matter, I would gladly have furnished it at
Anesthesia-Alzheimer Disease Link Probed
Authors: Bridget M. Kuehn
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence of chronic bronchitis in Rhodesian Africans.
Authors: J B Cookson, G Mataka
Journal: Thorax (1978)

The prevalence of chronic bronchitis in the African population of a small township in Rhodesia was estimated using two questionnaires, both based on those of the British Medical Research Council. The first, a screening questionnaire, was put to 9768 subjects aged 5 years and above and the second, a more detailed questionnaire, to random selections of these grouped according to their replies. Repeat interviews were used to assess the accuracy of the questionnaires. The overall prevalence of chronic bronchitis was 1.12%. This is much lower than most other surveys elsewhere. There was little evidence of an increase in prevalence with age, and rates were not significantly different in the two sexes. The prevalence of complications and of other chest symptoms was correspondingly low. The proportion of bronchitics who smoked was not significantly higher than in the controls. Amounts smoked, however, were generally much lower than in other populations, and this, together with low levels of pollution, probably account for the prevalence findings.
Investigation of the use of the pulsed dye laser in the treatment of Bowen's disease using 5-aminolaevulinic acid phototherapy
Authors: J.E.R. Britton, V. Goulden, G. Stables, M. Stringer, R. Sheehan-Dare
Journal: British Journal of Dermatology (2005)

Journal Article Investigation of the use of the pulsed dye laser in the treatment of Bowen's disease using 5‐aminolaevulinic acid phototherapy Get access J.E.R. Britton, J.E.R. Britton Leeds Centre for Dermatology, Leeds General Infirmary, Leeds, West Yorkshire, U.K. *Centre for Photobiology and Photodynamic Therapy, Department of Medical Physics, University of Leeds, Leeds, West Yorkshire, U.K J.E.R. Britton. E‐mail: info@dermatology.co.uk Search for other works by this author on: Oxford Academic Google Scholar V. Goulden, V. Goulden Leeds Centre for Dermatology, Leeds General Infirmary, Leeds, West Yorkshire, U.K. *Centre for Photobiology and Photodynamic Therapy, Department of Medical Physics, University of Leeds, Leeds, West Yorkshire, U.K Search for other works by this author on: Oxford Academic Google Scholar G. Stables, G. Stables Leeds Centre for Dermatology, Leeds General Infirmary, Leeds, West Yorkshire, U.K. *Centre for Photobiology and Photodynamic Therapy, Department of Medical Physics, University of Leeds, Leeds, West Yorkshire, U.K Search for other works by this author on: Oxford Academic Google Scholar M. Stringer, M. Stringer Leeds Centre for Dermatology, Leeds General Infirmary, Leeds, West Yorkshire, U.K. *Centre for Photobiology and Photodynamic Therapy, Department of Medical Physics, University of Leeds, Leeds, West Yorkshire, U.K Search for other works by this author on: Oxford Academic Google Scholar R. Sheehan‐Dare R. Sheehan‐Dare Leeds Centre for Dermatology, Leeds General Infirmary, Leeds, West Yorkshire, U.K. *Centre for Photobiology and Photodynamic Therapy, Department of Medical Physics, University of Leeds, Leeds, West Yorkshire, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 4, 1 October 2005, Pages 780–784, https://doi.org/10.1111/j.1365-2133.2005.06830.x Published: 01 October 2005 Article history Accepted: 25 November 2004 Published: 01 October 2005
Effects of pressure gradients between branches of the left coronary artery on the pressure axis intercept and the shape of steady state circumflex pressure-flow relations in dogs.
Authors: L M Messina, F L Hanley, P N Uhlig, R W Baer, M T Grattan, J I Hoffman
Journal: Circulation Research (1985)

When steady state pressure-flow relations are studied in the circumflex coronary artery, pressure gradients develop between it and other branches of the left coronary artery. To assess the effects of these pressure gradients, we compared the pressure axis intercept and shape of steady state circumflex pressure-flow relations in the presence and absence of gradients after autoregulation was abolished, both in the beating heart and during long diastoles in dogs. We used peripheral coronary pressures and radionuclide-labeled microspheres to assess arterial collateral flow. In the beating heart, interarterial pressure gradients reduced the curvature at low circumflex pressures, and overestimated the mean pressure axis intercept by 7.8 mm Hg (P less than 0.05). The results were similar for the pressure-flow relations derived during long diastoles. This overestimation exaggerates the difference between the pressure axis intercept and coronary sinus pressure. The peripheral coronary pressure and microsphere results indicate that these effects are mediated largely by arterial collateral flow.
Use of Lucozade and glucagon by ambulance staff in hypoglycaemia.
Authors: L. Yaxley, R. H. Greenwood
Journal: BMJ (1992)

Nursing time must be allowed for cleaning and disinfecting sigmoidoscopes during a list, and more than one sigmoidoscope may be required.Nursing time is required for correctly maintaining sigmoidoscopes and disinfection equipment weekly to keep all equipment in good condition and prevent cross infection.Sigmoidoscopy can be performed by general practitioners, but they must recognise that it is costly with important health and safety aspects.
Abstract 3520: The use of vasodilators to enhance efficacy of hypoxia or acid activated prodrugs in pancreatic cancers
Authors: Heather H. Cornnell, Amanda F. Baker, Tedman A. Torres, Arig Ibrahim Hashim, Katarzyna A. Rejniak, Robert A. Gatenby, Robert J. Gillies
Journal: Cancer Research (2011)

Abstract The vasculature of tumors is torturous and immature and in many cases lacks tone (the ability to self-regulate pressure). The administration of vasodilating agents induces a drop in systemic blood pressure which is not matched in the tumor, resulting in decreased intratumoral perfusion due to the “steal phenomenon”. This research uses this phenomenon to induce decreased tumor perfusion which results in increased tumor acidity and hypoxia. We hypothesize that this change in the tumor microenvironment can be used in combination with hypoxia- and acid-activated prodrugs (HAPs and AAPs) to enhance their efficacy, by increasing both the depth and distribution of hypoxia or acidosis within the tumor. Specifically, we have investigated the administration of hydralazine in several pancreatic xenograft tumors and used a needle microelectrode to measure decreases in pH as a result of decreased perfusion. We have also employed a computational math model to investigate the timing of the delivery of both hydralazine and HAPs to optimize the cell death. Preliminary computational results suggest that multiple rounds of vasodilators may be given with a single round of HAPs, depending on several factors including duration of vasodilation effect and half-life of the HAP. The pH investigation showed a substantial pH drop in one tumor type (MiaPaca2), but no change in two others (HS766t and SU8686), suggesting that the ‘steal’ phenomenon is not universal. Preliminary data suggest that combination therapy in the ‘steal’-sensitive models will increase efficacy. We are continuing research with the combination therapy, employing the timing strategies suggested by the computational models. We are also investigating different imaging modalities to monitor the effects of the steal phenomenon, including Ultrasound (for perfusion) and MRI (for bulk tumor changes and monitoring pH). In conclusion, the preliminary data supports the hypothesis that vasodilatation agents may be used to induce increases in acidosis and hypoxia within the microenvironment of some (but not all) tumors. These effects can be taken advantage of through combination with HAPs or AAPs to enhance antitumor effects. Further, computational math models can be employed to help determine the best timing for the combination therapies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3520. doi:10.1158/1538-7445.AM2011-3520
A huge intra-abdominal mass in a young man
Authors: T Tsujino, H Kogure, N Sasahira, H Isayama, M Tada, T Kawabe, M Omata, M Akahane, K Sano, M Makuuchi
Journal: Gut (2007)

A 19-year-old man presented to our department because of a 3-year history of left upper abdominal distention. He had no notable past medical history such as abdominal trauma or pancreatitis. On physical examination, a huge elastic hard mass …
Gordon Brown turns waiting time targets into a patient's right
Authors: H. Mooney
Journal: BMJ (2009)

NHS patients in England who have suspected cancer will have the right to see a specialist within two weeks, Gordon Brown has announced.

Under the government’s new plans, primary care trusts will be required to pay for private consultations for patients if NHS hospitals cannot meet the timescale.

The pledge forms part of the government’s draft legislative programme, “Building Britain’s Future,” unveiled on Monday.

The proposals also include giving patients a number of other entitlements in their NHS care. They will have the right to an operation within 18 weeks of first seeing their GP, to a free health …
Percutaneous Transluminal Therapy of Occluded Saphenous Vein Grafts
Authors: Uri Rosenschein, Georg Gaul, Raimund Erbel, Franz Amann, Diego Velasguez, H. Stoerger, Ruediger Simon, German Gomez, Joerg Troster, Antonio Bartorelli, Michael Pieper, Zenon Kyriakides, Shlomo Laniado, Hylton I. Miller, Alain Cribier, Jean Fajadet
Journal: Circulation (1999)

Background —Percutaneous transluminal treatment of a thrombotic vein graft yields poor results. We have previously reported our experience with transluminal percutaneous coronary ultrasound thrombolysis (CUT) in the setting of acute myocardial infarction (AMI). This report describes the first experience with ultrasound thrombolysis in thrombus-rich lesions in saphenous vein grafts (SVGs), most of which were occluded. Methods and Results —The patients (n=20) were mostly male (85%), aged 64±4 years old. The presenting symptom was AMI in 2 patients (10%) and unstable angina in the rest. Fifteen patients (75%) had totally occluded SVGs. The median age of clots was 6 days (range, 0 to 100 days). The ultrasound thrombolysis device has a 1.6-mm-long tip and fits into a 7F guiding catheter over a 0.014-in guidewire in a “rapid-exchange” system. CUT (41 kHz, 18 W, ≤6 minutes) led to device success in 14 (70%) of the patients and residual stenosis of 65±28%. Procedural success was obtained in 13 (65%) of the patients, with a final residual stenosis of 5±8%. There was a low rate of device-related adverse events: 1 patient (5%) had a non–Q-wave myocardial infarction, and distal embolization was noted in 1 patient (5%). Adjunct PTCA or stenting was used in all patients. There were no serious adverse events during hospitalization. Conclusions —Ultrasound thrombolysis in thrombus-rich lesions in SVGs offers a very promising therapeutic option.
A History of Mental Retardation
Authors: Winifred F. Storey
Journal: JAMA (1984)

This is indeed a history. The facts are presented with that quality of assurance rooted in thorough research. The unfolding of these facts creates an impact as strong as it is unexpected, given the unobtrusive prose style of the author. The reader is coerced into acknowledging a very specific form of man's inhumanity to man that has persisted for millennia in cultures throughout the world. Since ancient times, it has been a persistently demeaning form of inhumanity, such that the term "civilization" both in word and in intent requires rethinking and redefinition. R. C. Scheerenberger's historical overview of eons of society's contempt for the person considered to be mentally retarded constitutes a factual historical perspective. Society is presented with a challenge as old as the history of man and one that remains unmet effectively even today. Not in any aspect of the author's presentation is the historic and irresponsible exclusion
Chloasma and the "Pill".
Authors: R. Carruthers
Journal: BMJ (1967)

Chloasma as a side-effect of oral contraceptives is probably due to both the estrogen and progestogen components with progestogen acting on the estrogen-primed melanocytes.  Incidence of chloasma increases with duration and dosage of oral contraceptive use.  The condition is caused by both combined and sequential preparations and is likely to be precipitated by sunlight in chloasma-prone patients who have taken anovulants in high dosage or for prolonged periods.
187. Strategies of Intravascular Delivery of Naked DNA into Rat Skeletal Muscle
Authors: Zhen Jia, István Dankó
Journal: Molecular Therapy (2005)

Background: Due to its large mass and ability to express naked plasmid DNA (pDNA), skeletal muscle is an attractive target for non-viral gene transfer. Further development of this approach requires improved stability of gene expression and identification of the minimal muscle mass required to maintain metabolic correction. In this study we evaluated the efficiency of various vascular access routes in different muscle groups of the rat hind-limb and comparation of viral and muscle-specific promoters for reporter gene expression.
Null-hypothesis tests are not completely stupid, but Bayesian statistics are better
Authors: David Rindskopf
Journal: Behavioral and Brain Sciences (1998)

Unfortunately, reading Chow's work is likely to leave the reader more confused than enlightened. My preferred solutions to the “controversy” about null- hypothesis testing are: (1) recognize that we really want to test the hypothesis that an effect is “small,” not null, and (2) use Bayesian methods, which are much more in keeping with the way humans naturally think than are classical statistical methods.
Anticoagulant treatment is effective in atrial fibrillation
Authors: J. P. Robson, G. Y. H. Lip
Journal: BMJ (2013)

Spence’s concerns about bleeding and lack of efficacy in stroke prevention are well made for aspirin.1 The continued prescription of aspirin for 40% of people with atrial fibrillation lacks evidence of benefit in most cases and may be harmful, especially in elderly people.2

However, Spence is seriously misinformed about anticoagulant treatment in atrial fibrillation. Such treatment is highly effective, reducing strokes by 64% and all cause mortality by …
Case 23-1968
Authors: Edgar S. Cathcart, Richard B. Cohen
Journal: New England Journal of Medicine (1968)

Presentation of Case First admission. A sixty-year-old woman was admitted to the hospital because of splenomegaly.During the year before entry soreness in the right lower quadrant of the abdomen occurred intermittently. A week before admission her physician found that the spleen was enlarged. She had had no skin rash, abnormal bruising or tendency to bleed. For many years there had been pain and limitation of motion in the neck, shoulder, first finger and thumb.The neck was normal; the cervical, axillary and inguinal lymph nodes were not enlarged. The lungs were clear. The point of maximum cardiac impulse . . .
EMBOLIA CUTIS MEDICAMENTOSA: LOCAL ARTERIAL EMBOLISM FOLLOWING THE INJECTION OF MERCURIC SALICYLATE IN OIL
Authors: E. A. Skolnik
Journal: JAMA (1930)

The unintentional injection of oily suspensions of mercury or bismuth into an artery of the buttock is a very rare accident in the treatment of syphilis. Gammel 1 has reviewed the literature and reported five cases in his two papers on this subject. In the less severe cases there was only immediate severe pain, followed by induration of the buttock and bluish, reticulated mottling of the overlying skin. These conditions disappeared in about two weeks. In the severe cases there were extreme immediate pain, high temperature, constitutional symptoms, local induration, persistent soreness and reticulated, bluish discoloration of the skin. Occasionally sloughs formed, leaving ulcers. The external genitalia, bladder, vagina and rectum were sometimes involved. Nerve injury with paralysis of some of the leg muscles has occurred. In the excised tissue Gammel 2 demonstrated the heavy metal in the lumens of the cutaneous arterioles. He thought that the incidence of such
Winter draws on
Authors: J. O. Drife
Journal: BMJ (1998)

Years ago a snowy haired anatomy lecturer used to make us cringe with his double entendres. Smutty jokes can be funny if they have a touch of wit but once they lose their freshness they are just embarrassing, even to preclinical students.

That sad old man is gone now but his spirit lives on in the British advertising industry. The latest blitz from behind the admen's bicycle sheds is promoting brown bread, of all things. “Butter me up …
Letter: Malignant carcinoid tumour with gangrene of the small intestine.
Authors: F Hartveit, R Laurini, J Eide
Journal: BMJ (1974)

in one or more skeletal muscles, I asserted that multiple abscesses were a classical feature of the disease.A classical presentation is not necessarily the most commonly en- countered but is one in which the diagnosis is most likely to be correct and generally acceptable.
VISUAL FACTORS IN EQUILIBRATION, ESPECIALLY AVIATION
Authors: PERCY FRIDENBERG
Journal: JAMA (1918)

The great importance of aerial flight in modern warfare, and the need of full information as to the functional integrity of aviators, has shown how a practical demand in medical science can almost immediately produce a supply in the standardization and application of labyrinthine tests which until comparatively recently were, if not quite theoretical, at least not applied so uniformly, generally and accurately as to become a routine measure of value. At present, the rotational tests can be carried out in less than a half hour, and the vertigo, past pointing and falling, in fact, the entire labyrinthine reaction, determined and recorded. This is due largely to the use of a standard chair that can be stopped on the second and rotated evenly at a given speed, and to the control of all tests with the stop watch. It has generally been assumed that a normal labyrinth is the sine