THE CEREBRAL CIRCULATION*
Authors: STANLEY COBB
Journal: Annals of Internal Medicine (1933)

Article1 September 1933THE CEREBRAL CIRCULATIONXXV. REMARKS ON CLINICAL PHYSIOLOGYSTANLEY COBB, M.D.STANLEY COBB, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-3-292 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt will be universally agreed that blood must go to the brain if the human organism is to function mentally and physically. It is, therefore, important to know all possible facts about the cerebral circulation—in what ways it resembles circulation elsewhere in the body, and in what ways it differs. It may be stated at the beginning that all nerve cells of the central nervous system are easily injured by lack of oxygen. This sensitiveness to anemia is most marked in the most highly integrated centers, e.g. the nerve cells of the cerebral cortex. The cells of the more automatic...References1. FORBES HSPREVIOUS PAPERS ON THE CEREBRAL CIRCULATION: I. : Cerebral circulation; observation and measurement of pial vessels, Arch. Neurol. and Psychiat., 1928, xix, 751-761. II. COBB, S., and TALBOTT, J. H.: Studies in cerebral circulation; quantitative study of cerebral capillaries, Trans. Assoc. Am. Phys., 1927, xlii, 255-262. III. FORBES, H. S., and WOLFF, H. G.: Cerebral circulation; vasomotor control of cerebral vessels, Arch. Neurol. and Psychiat., 1928, xix, 1057-1086. IV. WOLFF, H. G., and FORBES, H. S.: Cerebral circulation; action of hypertonic solutions, Part I, Arch. Neurol. and Psychiat., 1928, xx, 73-83. IV. KUBIE, L. S., and HETLER, D. M.: Cerebral circulation; action of hypertonic solutions, Part II, Arch. Neurol. and Psychiat., 1928, xx, 749-755. V. WOLFF, H. G., and FORBES, H. S.: Cerebral circulation; observations of the pial circulation during changes in intracranial pressure, Arch. Neurol. and Psychiat., 1928, xx, 1035-1047. VI. WOLFF, H. G., and BLUMGART, H.: Cerebral circulation; effect of normal and of increased intracranial cerebrospinal fluid pressure on velocity of intracranial blood flow, Arch. Neurol. and Psychiat., 1929, xxi, 795-804. VII. TALBOTT, J. H., WOLFF, H. G., and COBB, S.: Cerebral circulation; changes in cerebral capillary bed following cervical sympathectomy, Arch. Neurol. and Psychiat., 1929, xxi, 1102-1106. VIII. COBB, S.: Cerebral circulation; quantitative study of capillaries in hippocampus, Arch. Surg., 1929, xviii, 1200-1209. IX. COBB, S.: Cerebral circulation; relationship of cervical sympathetic nerves to cerebral blood supply, Am. Jr. Med. Sci., 1929, clxxviii, 528-536. X. FORBES, H. S., WOLFF, H. G., and COBB, S.: Cerebral circulation; action of histamine, Am. Jr. Physiol., 1929, lxxxix, 266-272. XI. WOLFF, H. G.: Cerebral circulation; action of acetyl choline, Arch. Neurol. and Psychiat., 1929, xxii, 686-690.—Cerebral circulation; action of extract of posterior lobe of pituitary gland, ibid., 691-694.—Cerebral circulation; action of amyl nitrite, ibid., 695-699. XII. WOLFF, H. G., and LENNOX, W. G.: Cerebral circulation; effect on pial vessels of variations in oxygen and carbon dioxide content of blood, Arch. Neurol. and Psychiat., 1930, xxiii, 1097-1120. XIII. COBB, S.: Cerebral circulation; question of "end-arteries" of brain and mechanism of infarction, Arch. Neurol. and Psychiat., 1931, xxv, 273-280. XIV. LENNOX, W. G., and LEONHARDT, E.: Cerebral circulation; the respiratory quotient of the brain and of the extremities in man, Arch. Neurol. and Psychiat., 1931, xxvi, 719-724. XV. LENNOX, W. G., and LEONHARDT, E.: Cerebral circulation; the effect of mental work, Arch. Neurol. and Psychiat., 1931, xxvi, 725-730. XVI. COBB, S., and FREMONT-SMITH, F.: Cerebral circulation; changes in human retinal circulation and in pressure of cerebrospinal fluid during inhalation of mixture of carbon dioxide and oxygen, Arch. Neurol. and Psychiat., 1931, xxvi, 731-736. XVII. WEISS, S., and LENNOX, W. G.: Cerebral circulation; cerebral blood flow and vasomotor response of minute vessels of human brain to histamine, Arch. Neurol. and Psychiat., 1931, xxvi, 737-744. XVIII. FINESINGER, J. E.: Cerebral circulation; effect of caffein on cerebral vessels, Arch. Neurol. and Psychiat., 1932, xxviii, 1290-1325. XIX. COBB, S., and FINESINGER, J. E.: Cerebral circulation; vagal pathway of the vasodilator impulses, Arch. Neurol. and Psychiat., 1932, xxviii, 1243-1256. XX. LENNOX, W. G., and GIBBS, E. L.: Blood flow in brain and leg of man, and changes induced by alteration of blood gases, Jr. Clin. Invest., 1932, xi, 1155-1177. XXI. FORBES, H. S., and KRUMBHAAR, C. C.: The effect of hydrogen sulfide. (In press.) XXII. 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CrossrefGoogle Scholar37. HOLMESSHERIF EGMA: Relationship between sugar in blood and lactic acid in brain, Biochem. Jr., 1932, xxvi, 381-387. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STANLEY COBB, M.D.Affiliations: Boston, Massachusetts*Read at the Montreal Meeting of the American College of Physicians, February 7, 1933.From the Neurological Unit, Boston City Hospital, Boston and the Department of Neuropathology, Harvard Medical School, Boston, Mass.This work was aided by the Josiah Macy Jr. Foundation.The paper is a coördination of some clinically interesting observations made in a study of the cerebral circulation during the past five years in the Department of Neuropathology at the Harvard Medical School. The titles of the original papers so far published are given at the beginning of the bibliography. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Therapeutic Use of Procaine Hydrochloride Injection�ber die Blutversorgung der menschlichen Retina unter der Einwirkung ver�nderter Sauerstoffspannung, von Kohlens�ure, Hyperventilation und AdrenalinThrombosis of the Internal Carotid Artery.Beitrag zur Kenntnis der Blut-LiquorschrankeDie Zirkulationsstörungen des Rückenmarks und GehirnsBibliographyDie Migräne 1 September 1933Volume 7, Issue 3Page: 292-302KeywordsAnemiaBloodBrainCellsCentral nervous systemNeuronsNeuropathologyOxygen ePublished: 1 December 2008 Issue Published: 1 September 1933 PDF downloadLoading ...