tbuckley/cabot-search huggingface dataset:
The Consult Guys - Dressed to Kill? Can Neckties Spread Infection?
Authors: Geno J. Merli, Howard H. Weitz
Journal: Annals of Internal Medicine (2014)

Web Exclusives21 October 2014The Consult Guys - Dressed to Kill? Can Neckties Spread Infection?FREEGeno J. Merli, MD and Howard H. Weitz, MDGeno J. Merli, MDSearch for more papers by this author and Howard H. Weitz, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G14-3010 SectionsSupplemental MaterialAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Consult Guys bring a new perspective to the art and science of medicine with lively discussion and analysis of real-world cases and situations.For more videos from and information on The Consult Guys, visit www.annals.org/ConsultGuys. Comments0 CommentsSign In to Submit A Comment Abdul Waheedresident at St joes Pontiac MI25 November 2014 Un-necessary This seem to be ridiculous to me. I think some of the attorneys are behind this who give advertisement with no fee guaranteed and we the physicians fall prey to this kind of propiganda. Tomorrow if some one comes up with the idea of spreading infection through glasses, cell phone , white coats, shoes , shirts . Please do not ban those.We cannot make fun saying that wearing a nonprofessional attire (shirt in the last scene )that you are still my physician. Look at patient satisfaction survey (80%). Author, Article, and Disclosure InformationAffiliations: Disclosures: Geno J. Merli, MD, reports the following: Research grants/contracts: Bristol-Myers Squibb, Bayer, sanofi-aventis; Consultancies: Bristol-Myers Squibb, Bayer, sanofi-aventis. Howard H. Weitz, MD, reports that he has no financial relationships or interests to disclose. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 October 2014Volume 161, Issue 8Page: CG10KeywordsConflicts of interestResearch grantsResearch reporting guidelines ePublished: 21 October 2014 Issue Published: 21 October 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.Loading ...
Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias
Authors: Ellen Weisberg, Laurie Catley, Renee D. Wright, Daisy Moreno, Lolita Banerji, Arghya Ray, Paul W. Manley, Juergen Mestan, Doriano Fabbro, Jingrui Jiang, Elizabeth Hall-Meyers, Linda Callahan, Jamie L. DellaGatta, Andrew L. Kung, James D. Griffin
Journal: Blood (2006)
The Technique of Surgical Diathermy
Authors: A. Eidinow
Journal: BMJ (1931)

DIATHERMY[ IHE BrTItSH AA vertigo, and there was no homolateral weakness of the limbs or muscular inco-ordination.On January 18th th-e use of the tube was discontinued, the discharge having ceased.It was tlhought that the tube might be obstructing the sinus, aind the latter was kept open by fine forceps during the next two days.Between January 20th and 29th, apart from a quick pulse and a moderate pyrexia, there were all the indications of excellent progress.The eye changes disappeared except the nystagmus, incon- tinence ceased, and the appetite was fully restored.The mind was clear and animated.On January 31st a sudden relapse occurred, and the )atient became rapidly comatose again.The tube was reinserted, but for several days she remained in a moribund condition, and could not be induced to swallow more than an occasional teaspoonful of water.Hiccup was a prominent symptom at this stage.After these cri tical days had passed rapid improvement set in.The pulse and temperature remained normal and progress was uninterrupted.The tube drained freely and was left in for a fortnight, until it could no longer be inserted.During the whole of this period the tube was taken out for cleaning twice daily.It remained, however, stitched to the skin all the time, so that there was no uncertainty in reintroducing it to the proper depth.The girl was able to get up on February 19th and returned home on February 25th.Since thein she has made uniremitting progress.The nystagmus disappeared in a week or two.Now, at the end of April, she is in vigorous health and entirely free from any ill effects of her serious illness. CONCLUSIONSThe conclusions to be draw;-from this case are:1.That brain abscess may develop insidiously, and that the first intimation may be incipient coma.2. That a hypodermic syringe may discover pus when other means fail.3. That drainage should be continued as long as
Osteomyelitis: A Review of Clinical Features, Therapeutic Considerations and Unusual Aspects
Authors: Francis A. Waldvogel, Gerald Medoff, Morton N. Swartz
Journal: New England Journal of Medicine (1970)

ALTHOUGH osteomyelitis often falls into the purview of the orthopedic surgeon, the internist and pediatrician are also very frequently involved in the initial diagnosis and the subsequent antibiotic management of patients with bone infections. The wide spectrum of manifestations of disease related to the site of involvement, the infecting organism, the initiating event and the acute or chronic course of the illness provides many questions not yet fully answered. Has the frequency of the disease continued to change two decades after the introduction of antimicrobial agents? Is the bacteriology of osteomyelitis the same as in the preantibiotic era, or does . . .
III.--On a Micro-Organism in the Blood of Influenza Patients
Authors: P. Canon
Journal: BMJ (1892)

DR. P. GUTTMANN.)]DURING the last few weeks I have, under the direction of Dr. Guttmann, examined the blood of twenty influenza patients in stained preparations, and in almost all cases I have found in the blood one and the same micro-organism.The examination of the blood was made in the following way: A drop of blood obtained by pricking the finger was received on a perfectly clean cover-glass; this cover-glass was placed upon another one, and the two then drawn apart.The preparations, after they had been thoroughly dried, were placed in absolute alcohol, in which they were left for at least five minutes.They were then taken out and placed in the following stain- ing solution (Czenzynke's solution): 1 Concentrated watery solution of methylene blue, 40 grammes; l per cent.eosin solution (dissolved in 70 per cent.alcohol), 20 grammes; dis- tilled water, 40 grammes.The cover-glasses immersed in this staining solution were placed in an incubator at a temperature of 370 C., and left there from three to six hours, ,when they were washed with water, dried, and embedded in Canada balsam.In the preparations of blood made in this ,manner where the red blood corpuscle were red, and the white ones blue, I found the above-mentioned micro- organism.It is found stained blue, sometimes in large ,quantities, but mostly sparingly, and only to be identified -after a long search (about 4 to 20 in the preparation).Sometimes it appears as a small diplococcus, sometimes, especially when it is more deeply stained, as a short bacillus.In six cases I have found it also in numerous larger and -smaller heaps of from 5 to 50 individual microbes with a very -characteristic appearance.In these six cases the blood was -drawn during a fall of temperature or shortly afterwards; in three of these no further rise of temperature occurred.From
High carbohydrate diet implicated in pancreatic cancer
Authors: D. Josefsen
Journal: BMJ (2002)

A diet high in carbohydrates may increase the risk of pancreatic cancer in sedentary and overweight women, some new US research suggests. The study is the first to implicate a modifiable risk factor other than smoking in the development of pancreatic cancer ( Journal of the National Cancer Institute 2002;94:1293-300)

Led by Dr Dominique Michaud of the US National Cancer Institute, and Charles Fuchs of the Brigham and Women's Hospital and the Dana-Farber Cancer Institute in Boston, the researchers set out to determine if foods that raise glucose levels after eating were linked to …
Post-traumatic stress disorder common among child survivors of Rwandan genocide
Authors: R. Dobson
Journal: BMJ (2009)

Two thirds of children and adolescents who survived the Rwandan genocide probably had post-traumatic stress disorder (PTSD) a year later, a survey has found ( International Journal of Epidemiology 2009, doi:10.1093/ije/dyn375).

More than 90% of child and adolescent survivors of the atrocities that occurred in Rwanda in 1994 witnessed killings and had their lives threatened. A further 35% lost immediate family members, and 30% witnessed rape or sexual mutilation. Nearly one in six children spent time hiding under dead bodies for protection.

“Symptom levels and rates of probable post-traumatic stress …
An Ethical Debate: Practical implications
Authors: R. A Sells
Journal: BMJ (1995)

The relation between transplant centres and intensive care units is a delicate one: while we are entitled to expect cooperation from intensivists in the provision of organs, transplant surgeons can do little to force intensive care staff to cooperate if bed space is limited or if emotional feeling against organ donation runs high. We can merely encourage and facilitate cadaveric donation by emphasising its humanitarian benefits and economic utility. We also try to help the staff with the process of donation through our regional transplant coordinator organisation.

To many transplanters, the elective ventilation protocol was a welcome initiative, and the plan to resuscitate stroke patients for organ donation was perceived as altruistic, imaginative, useful, and safe. The Exeter team …
"A FLUOROSCOPIC DUODENAL BUCKET"
Authors: Moses Einhorn
Journal: JAMA (1927)

To the Editor:  —In reading Dr. Sylvan D. Manheim's article on A Fluoroscopic Duodenal Bucket (The Journal, February 26, p. 644), I was immediately struck by the similarity between his bucket and the one I described (The Journal, May 22, 1926, p. 1615).  The points of similarity between the two buckets lie in the capsule shape, the three-part composition and the spiral arrangement of the middle portion, which are original and exclusive with my improvement of this type of apparatus. What served as further cause of surprise was that, although Dr. Manheim made free use of these innovations in constructing his own apparatus, he absolutely failed to indicate the source from which they were derived. Dr. Manheim was most familiar with my apparatus, as he was associated with me in the same clinic, where he was a frequent spectator at the clinical tests which I made with it previous to
Autoantibodies as predictors of disease
Authors: David Leslie, Peter Lipsky, Abner Louis Notkins
Journal: Journal of Clinical Investigation (2001)

Autoimmune diseasesActivation of the immune response is a major feature of many disease processes.Immune responses can be protective, as in infectious diseases, or destructive, as in autoimmune inflammatory diseases, or both.The immune response usually involves activation of both T and B cells, the latter producing antibodies that can be detected in the sera and can be used to guide the clinical management of certain diseases.Here, we focus on autoantibodies as predictive markers of disease.While the practical value of autoantibodies has been realized in some clinical conditions, it remains underutilized in the majority of diseases.Recognizing the clinical potential of autoantibodies and identifying appropriate populations to screen for such autoantibodies, we argue, could have rich practical rewards. Autoantibodies as markers of disease activity and severityAntibodies may reflect the presence, nature, and intensity of the immune response.Since in autoimmune diseases the immune response is itself part of the disease process, it is possible to use autoantibodies as markers of disease activity.Autoantibodies can be detected in diseases with a long prodrome during which there are no clinical symptoms.In some of these diseases autoantibodies can predict both the likelihood of clinical disease and the rate of progression to disease, that is, the disease activity.In organ-specific autoimmune diseases such as type 1 diabetes and thyroiditis, autoantibodies can be detected in peripheral blood years before the destruction of hormone-secreting cells leads to overt clinical symptoms.Hence, many such autoimmune diseases are long-term and chronic in nature (1, 2).A variety of studies have now shown a direct relationship between the titer of the autoantibodies and the severity of the disease (1-3). Autoantibodies as markers to define and classify diseaseIn patients with established disease, autoantibodies can help define the nature of the disease and provide mark-ers to classify the disease.For example, type 1 diabetes, thyroiditis, and adrenalitis are classified as autoimmune or not autoimmune, based on the presence or absence of disease-associated antibodies.Similarly, there are several causes of atrophic gastritis and of vitamin B12 deficiency, but the combination of the two, in association with autoantibodies to parietal cells or intrinsic factor, indicates that the cause is autoimmune gastritis, also called pernicious anemia (PA) (4).
Blood transfusion from another person doubles infection risk after CABG surgery
Authors: S. Mayor
Journal: BMJ (2009)

Having a blood transfusion from another person after coronary artery bypass grafting (CABG) is associated with a twofold increase in infection after operation, warns a US study, which also shows considerable variation in transfusion practices between different hospitals ( BMC Medicine 2009;7:37, doi:10.1186/1741-7015-7-37).

The practice of blood transfusion is currently in transition, after growing evidence in the last few years of adverse effects, particularly with allogeneic transplants, in which blood is provided by another person. To investigate this further, researchers from the University of Michigan evaluated outcomes in 24 789 patients undergoing CABG surgery at hospitals in the …
Papillary Cystadenocarcinoma of Both Ovaries
Authors: Gerard L. Gaudrault
Journal: New England Journal of Medicine (1948)

THE following case appears to be one of those mysterious cases that cannot be explained. After reading textbooks and journals I came to the conclusions that the patient had had actual surgical treatment four years after the onset of symptoms, that she had not been given x-ray therapy and that a hysterectomy had not been performed.Meigs1 states that cancer of the ovary of the malignant papillary cystadenoma type is about as malignant as any other epithelial growth and that bilateral oophorectomy and hysterectomy are the proper treatment. Jones2 reported 30 cases of papillary cystadenoma of the ovary and stated . . .
EPSTEIN-BARR VIRUS
Authors: Thomas Shope, George Miller
Journal: The Journal of Experimental Medicine (1973)

Epstein-Barr virus (EBV)-transformed autologous lymphoblasts were repeatedly inoculated into three squirrel monkeys. Each animal developed the heterophile antibodies of infectious mononucleosis and EBV-specific antibodies. After serologic responses had disappeared or markedly declined, the animals were challenged with either whole cells, cell filtrate, or cell ghosts. Animals challenged with living cells and cell ghosts developed agglutinin responses; the recipient of filtrate did not. The results suggest that EBV induces the appearance of the infectious mononucleosis heterophile antigen on the transformed cell membrane.
474 Hepatitis B virus genomic markers for hepatocellular carcinoma on full-genome sequencing of 332 patients
Authors: J.J.Y. Sung, S.K.W. Tsui, C.H. Tse, E.Y.T. Ng, K.S. Leung, K.H. Lee, T.S.K. Mok, A. Bartholomeusz, T.C.C. Au, M.D. Zhang, H.L.Y. Chan
Journal: Journal of Hepatology (2006)
Continuous control of the lumen of feline conduit arteries by blood flow rate
Authors: A. M MELKUMYANTS, S. A BALASHOV, E. S VESELOVA, V. M KHAYUTIN
Journal: Cardiovascular Research (1987)

Journal Article Continuous control of the lumen of feline conduit arteries by blood flow rate Get access ARTHUR M MELKUMYANTS, ARTHUR M MELKUMYANTS From the Department of Circulation Biomechanics and Control, Institute of Experimental Cardiology, USSR Cardiology Research Centre, Academy of Medical Sciences, Moscow, USSR Search for other works by this author on: Oxford Academic PubMed Google Scholar SERGEY A BALASHOV, SERGEY A BALASHOV From the Department of Circulation Biomechanics and Control, Institute of Experimental Cardiology, USSR Cardiology Research Centre, Academy of Medical Sciences, Moscow, USSR Search for other works by this author on: Oxford Academic PubMed Google Scholar ELENA S VESELOVA, ELENA S VESELOVA From the Department of Circulation Biomechanics and Control, Institute of Experimental Cardiology, USSR Cardiology Research Centre, Academy of Medical Sciences, Moscow, USSR Search for other works by this author on: Oxford Academic PubMed Google Scholar VLADIMIR M KHAYUTIN VLADIMIR M KHAYUTIN From the Department of Circulation Biomechanics and Control, Institute of Experimental Cardiology, USSR Cardiology Research Centre, Academy of Medical Sciences, Moscow, USSR Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 21, Issue 12, December 1987, Pages 863–870, https://doi.org/10.1093/cvr/21.12.863 Published: 01 December 1987 Article history Received: 04 April 1987 Accepted: 25 June 1987 Published: 01 December 1987
Haemolysis complicating viral hepatitis in patients with glucose-6-phosphate dehydrogenase deficiency.
Authors: T K Chan, D Todd
Journal: BMJ (1975)

Out of 20 patients with viral hepatitis whose glucose-6-phosphate dehydrogenase (G-6-PD) levels were normal, 14 had clinical evidence of a mild to moderate degree of haemolysis but in all the patients studied the half life of chromium-51-labelled red cells was shortened. Out of 18 viral hepatitis patients deficient in G-6-PD 17 had clinical evidence of haemolysis, and in eight this was more severe than in the group with normal G-6-PD values. Massive intravascular haemolysis occurred in four, three of whom died. The massive haemolysis was attributed to the presence of additional drug-induced oxidative stress to the G-6-PD-deficient red cells.
Levamisole, Immunostimulation, and the Acquired Immunodeficiency Syndrome
Authors: NARASIMHA SURAPANENI
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 January 1985Levamisole, Immunostimulation, and the Acquired Immunodeficiency SyndromeNARASIMHA SURAPANENI, M.D., RUKMANI RAGHUNATHAN, M.D., GILDON N. BEALL, M.D., KATHERINE DANIEL, R.N., M.N., THOMAS M. MUNDY, M.D.NARASIMHA SURAPANENI, M.D.Search for more papers by this author, RUKMANI RAGHUNATHAN, M.D.Search for more papers by this author, GILDON N. BEALL, M.D.Search for more papers by this author, KATHERINE DANIEL, R.N., M.N.Search for more papers by this author, THOMAS M. MUNDY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-1-137_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In addition to its antihelminthic and antianergic properties, levamisole is known to normalize the function of T lymphocytes in immunosuppressed patients without affecting B cells (1). We attempted to evaluate these properties in patients with the acquired immunodeficiency syndrome. Levamisole and other immunostimulants have been proposed as treatment for this syndrome but we are unaware of any clinical trials of levamisole.The five patients who participated in this study were homosexual men with the syndrome (ages, 29 to 37 years) who had recovered fromPneumocystis cariniipneumonia. All five patients had other opportunistic infections such as oral...References1. LIEBERMAN R and HSU M. Levamisole mediated restoration of cellular immunity in peripheral blood lymphocytes of patients with immune deficiency diseases. Clin Immunol Immunopathol. 1976;5:142-6. CrossrefMedlineGoogle Scholar2. GRIECO M, REDDY M, MANVAR D, AHUJA K, and MORIARTY M. In-vivo immunomodulation by isoprinosine in patients with the acquired immunodeficiency syndrome and related complexes. Ann Intern Med. 1984;101:206-7. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: NARASIMHA SURAPANENI, M.D.; RUKMANI RAGHUNATHAN, M.D.; GILDON N. BEALL, M.D.; KATHERINE DANIEL, R.N., M.N.; THOMAS M. MUNDY, M.D.Affiliations: Harbor-UCLA Medical Center Torrance, CA 90509 UCLA School of Medicine Los Angeles, CA 90024 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnti-HIV effect of immunomodulating agent, levamisole, in vitroApplication of Chemical Immunomodulators to the Treatment of Cancer and AIDSImmunomodulating agentsImmunotherapy in acquired immune deficiency syndrome and related syndromes 1 January 1985Volume 102, Issue 1Page: 137-137KeywordsAIDSCellsClinical trialsHomosexualsLymphocytesOpportunistic infectionsPneumocystis carinii pneumonia ePublished: 1 December 2008 Issue Published: 1 January 1985 PDF downloadLoading ...
Maintenance of silastic-teflon shunts for intermittent haemodialysis
Authors: C. S. McIntosh, J. C. Petrie, M. Macleod
Journal: BMJ (1969)

The occurrence of infection in the tissues surrounding external arteriovenous shunts was studied and die important relationship of pyogenic infection to clotting was confirmed. The local application of fusidic add tulle and lanolin greatly reduced the occurrence of both infection and clotting and the need for cannula replacement.Urokinase used for declotting shunts when standard procedures had failed, restored blood flow whether dotting was related to infection or to local vascular factors. This treatment is not advised when clotting is associated with a local abscess, as it may make cannula replacement necessary. Severe local vascular factors, such as metastatic calcification, Raynaud's phenomenon, and venous stenosis, may lead to poor blood flow, so that despite clot lysis elective cannula replacement or the creation of a subcutaneous arteriovenous fistula is required.
Disappearance From Meetings
Authors: Robert C. Douglass
Journal: JAMA (1982)

<h3>To the Editor.—</h3> In response to Dr Harold J. Ellner's discussion of "The Fine Art of Disappearing from Meetings" (1982;247:508) wherein he describes the problems of a hospital president of staff in retaining his audience, I offer the following. During a recent year as a hospital staff president, I, too, observed the clever means by which many members exited meetings early. It was also evident that most staff members crowded and congregated at the back of the room to facilitate easy egress, leaving the front rows unoccupied. Faced with this usual situation at a meeting of required attendance, I opened the meeting—then abruptly asked all in attendance to stand up, turn their chairs in the opposite direction, and be reseated. I proceeded to the back of the room, slid out a second lectern previously placed there, and resumed the meeting— squarely in front of the only exit. This exposed those