tbuckley/cabot-search huggingface dataset:
PTU-076 Management Of Inflammatory Bowel Disease (ibd) In Pregnancy In The Northern Deanery: Abstract PTU-076 Table 1
Authors: C Parker, M Gunn
Journal: Gut (2014)

<h3>Introduction</h3> A European consensus on issues surrounding IBD in pregnancy was published in 2010<sup>.1</sup> We conducted a questionnaire to gain information about knowledge and management of IBD in pregnancy in the Northern region in both gastroenterology consultants and specialist trainees. <h3>Methods</h3> A questionnaire assessing the management of IBD in pregnancy and pre-conception was devised. 34 questionnaires were given out at a joint trainee and trainer teaching session and were completed anonymously. <h3>Results</h3> 34 questionnaires were returned; 16 consultants, 14 trainees, 4 not specified. <h3>Pre-conception</h3> 22/34 (65%) routinely ask women of childbearing age about intentions to conceive, 16/34 (47%) routinely ask about contraception. If intending to conceive 24/34 (71%) would routinely give supplements (19/24 (79%) specified folate). <h3>Pre natal</h3> 29/34 (85%) would routinely refer to obstetrician on discovery of pregnancy, 24/34 (71%) would see more frequently during the pregnancy. 27/34 (79%) would advise Caesarean section (CS) in certain patient groups; 2 would not advise CS and 5 did not know. The suggested indications for CS by respondents were: perianal disease (24) ileoanal pouch (6), previous CS (1), uncontrolled disease (1), previous surgery (2). 20/34 would recommend the flu jab in pregnancy. <h3>Postnatal</h3> 10/34 (29%) were aware of live vaccinations that may be contraindicated in a neonate (7/10 were trainees). <h3>Medications</h3> specific questions were asked about which medications would be recommended to be stopped in the pre and ante-natal periods and which were considered safe in breastfeeding (See Table). <h3>Conclusion</h3> Within the North East Region there is a varied consensus to the management of IBD preconception and during pregnancy both in terms of medication and indication for surgery. This is despite the European consensus document. There are areas which could be improved; only 6 of 27 who would consider CS in certain groups would consider it for ileoanal pouch and although this should be tailored to each individual patient guidelines would suggest that CS be strongly considered in those with a pouch and perhaps further education in this area would be beneficial. Although the majority would ask about plans for conceiving, discussion of contraception occurs in less than half of consultations. We would advocate a combined approach for these patients in conjunction with an interested gastroenterologist and obstetrician in order to optimise management and outcomes. <h3>Reference</h3> Janneke van der Woude <i>et al</i>. <i>J Crohns Colitis</i> 2010:4:493–510 <h3>Disclosure of Interest</h3> None Declared.
TWO MORE CASES OF ORBITAL AND OCULAR GROWTHS, WITH SUBSEQUENT HISTORY OF CASES PRESENTED LAST YEAR.Read in the Section on Ophthalmology at the Forty-fourth Annual Meeting of the American Medical Association.
Authors: JOSEPH A. WHITE
Journal: JAMA (1893)

I here present for your consideration two cases of ocular growths which have come under my observation since our last meeting, thinking they might be of interest: <i>Case 1. Orbital Groivth, Fibro-sarcoma (Post-ocular</i>).—Betty Lytle, colored, age 24 of Blackstone, Va., came to me Sept. 27, 1892. In May, 1892, she had consulted her physician, Dr. Harris, about a severe pain across the forehead and through both temples. He could find nothing abnormal about the eyes, except a slight redness of the conjunctiva of the left eye. He treated her for neuralgia, but the pain still persisted and gradually grew worse. He could get no history of syphilis, but thinking the pain might be due to a gumma he put her on iodid of potash, but with no relief. The left eye soon began to show prominence without local signs of inflammation. He then concluded to send her to an oculist
Suplatast tosilate inhibits goblet-cell metaplasia of airway epithelium in sensitized mice
Authors: Jae Jeong Shim, Karim Dabbagh, Kiyoshi Takeyama, Pierre-Regis Burgel, Trang P. Dao-Pick, Iris F. Ueki, Jay A. Nadel
Journal: Journal of Allergy and Clinical Immunology (2000)
One in seven people in England can't get GP appointment within two days, survey shows
Authors: R. Dobson
Journal: BMJ (2008)

Nearly one in seven people in England cannot get an appointment with a GP within the current target of two working days, although most are satisfied with their care when they do get a consultation, a new survey has found.

The national survey of 69 000 people by the Healthcare Commission also showed that a quarter were unable to book an appointment three or more days in advance and that there were wide geographical variations in this proportion.

More patients than in previous such surveys are completely satisfied with the care they get in general practices and health centres, with high proportions saying that they are treated with dignity and listened to carefully. But the survey also shows that patients continue to have concerns about practices’ opening hours, difficulties in booking appointments in advance, and problems in contacting practices by telephone.

“People clearly do want to be able to see a GP more easily and …
UK patients group hits back at anti-vivisectionists
Authors: S. Mayor
Journal: BMJ (2002)

A UK patients' advocate group has attacked anti-vivisection activists, alleging—in a report published last week—that they mislead the public and fail to invest in research designed to find alternatives to animal research.

The report, Anti-vivisection Unmasked , was published by the UK charity Seriously Ill for Medical Research. Its membership includes patients—many of whom are seriously ill with a range of conditions including Alzheimer's disease, Parkinson's disease, and multiple sclerosis—and their relatives and carers. The charity's medical panel comprises several leading researchers including Professor Roy Calne and Professor Robert Winston.

The report argued that some anti-vivisection groups use “tactics of deception” designed to manipulate …
Long-continued Inhibition of Gastric Secretion by Poldine Methosulphate in Patients with Peptic Ulcer
Authors: A. H. Douthwaite, T. H. Hills, J. N. Hunt
Journal: BMJ (1961)

Antacids are widely used to control pain and promote healing in patients with peptic ulcer.Although antacids, provided they are taken often enough and in large quantities (Clark and Hunt, 1958), are unquestionably effective in maintaining a lowered acidity in the gastric contents during the day, they have no influence on the acidity of the gastric contents during sleep.Instead of neutralizing the acid after it is secreted, it would seem better to try to inhibit the secretion of acid continuously even when the patient is in remission.This paper is concerned with treatment of patients with peptic ulcer along these lines, using an anticholinergic substance, poldine methosulphate (" nacton "), which reduces by about one-half the gastric secretion of acid without producing noticeable side-effects. Present InvestigationIn-patients of a previous trial (Douthwaite and Hunt, 1958) and several new patients have been followed as out-patients for periods up to three years.All those studied were admitted to the wards under the care of the consultant physicians because a full course of medical treatment under the best conditions was necessary.With the permission of the clinicians concerned, the trial was discussed with the patients.All except one of those approached accepted the offer.Relevant facts about the patients, who are all men, are summarized in Table I.The mean duration of their dyspepsia was 10 years, two patients had gastric ulcers and 14 had duodenal ulcers.For the most part the
Nonnegligent foreign object cases
Authors: A. R. Holder
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract LB-157: VISTA deficiency synergizes with a non-redundant immune checkpoint pathway and leads to enhanced immune activation
Authors: Li Wang, Isabelle LeMercier, Arief Suriawinata, Wenna Chen, Randolph J. Noelle, Jiannan Li
Journal: Cancer Research (2014)

Abstract V-domain Ig suppressor of T cell activation (VISTA) is a novel negative checkpoint ligand that suppresses T-cell mediated immune responses. Previous studies using VISTA-neutralizing monoclonal antibody show that VISTA-blockade enhances T cell-activation in an inflammatory disease model EAE, as well as in murine tumor models. Current study describes a comprehensive characterization of VISTA knockout (KO) mice. We show that despite the apparent normal hematopoietic development in young ko mice, VISTA genetic deficiency leads to a pro-inflammatory phenotype in aged animals, as well as enhanced T-cell activation in response to acute antigen immunization. In addition, we show that VISTA deficiency significantly enhanced disease development in a spontaneous model of autoimmune disease, which is correlated with the spontaneous activation of auto-antigen specific CD4+ T cells. Lastly, when combined with the genetic deficiency of another checkpoint molecule, synergistic or additive immune activation was observed. The implication of such enhanced immunity in cancer development and treatment will be discussed. Citation Format: Li Wang, Isabelle LeMercier, Arief Suriawinata, Wenna Chen, Randolph J. Noelle, Jiannan Li. VISTA deficiency synergizes with a non-redundant immune checkpoint pathway and leads to enhanced immune activation. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-157. doi:10.1158/1538-7445.AM2014-LB-157
AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis
Authors: István Vadász, Laura A. Dada, Arturo Briva, Humberto E. Trejo, Lynn C. Welch, Jiwang Chen, Péter T. Tóth, Emilia Lecuona, Lee A. Witters, Paul T. Schumacker, Navdeep S. Chandel, Werner Seeger, Jacob I. Sznajder
Journal: Journal of Clinical Investigation (2008)

Hypercapnia (elevated CO2 levels) occurs as a consequence of poor alveolar ventilation and impairs alveolar fluid reabsorption (AFR) by promoting Na,K-ATPase endocytosis. We studied the mechanisms regulating CO2-induced Na,K-ATPase endocytosis in alveolar epithelial cells (AECs) and alveolar epithelial dysfunction in rats. Elevated CO2 levels caused a rapid activation of AMP-activated protein kinase (AMPK) in AECs, a key regulator of metabolic homeostasis. Activation of AMPK was mediated by a CO2-triggered increase in intracellular Ca2+ concentration and Ca2+/calmodulin-dependent kinase kinase-β (CaMKK-β). Chelating intracellular Ca2+ or abrogating CaMKK-β function by gene silencing or chemical inhibition prevented the CO2-induced AMPK activation in AECs. Activation of AMPK or overexpression of constitutively active AMPK was sufficient to activate PKC-ζ and promote Na,K-ATPase endocytosis. Inhibition or downregulation of AMPK via adenoviral delivery of dominant-negative AMPK-α1 prevented CO2-induced Na,K-ATPase endocytosis. The hypercapnia effects were independent of intracellular ROS. Exposure of rats to hypercapnia for up to 7 days caused a sustained decrease in AFR. Pretreatment with a β-adrenergic agonist, isoproterenol, or a cAMP analog ameliorated the hypercapnia-induced impairment of AFR. Accordingly, we provide evidence that elevated CO2 levels are sensed by AECs and that AMPK mediates CO2-induced Na,K-ATPase endocytosis and alveolar epithelial dysfunction, which can be prevented with β-adrenergic agonists and cAMP.
Effect of Peritubular Protein Concentration on Reabsorption of Sodium and Water in Isolated Perfused Proximal Tubules
Authors: Masashi Imai, Juha P. Kokko
Journal: Journal of Clinical Investigation (1972)

Micropuncture studies have indicated that variation in peritubular oncotic pressure influences net transport of fluid out of the proximal tubule. The present in vitro studies on isolated perfused rabbit proximal convoluted tubules were designed to examine whether protein concentration gradient must act across the peritubular capillary membrane to influence reabsorption, or whether it can exert a direct effect across the tubular basement membrane 71 proximal tubules were perfused with ultrafiltrate made isosmolal to bathing fluids, the latter having identical electrolyte composition as the perfusing ultrafiltrate, but adjusted to three oncotic pressures: hypooncotic, protein 0.0 g/100 ml; control isooncotic serum, protein 6.4 g/100 ml; and hyperoncotic, protein 12.5 g/100 ml. Net volume flux (nl/mm per min), net Na flux (nEq/mm per min), unidirectional Na flux from bath to lumen (nEq/mm per min), and passive permeability coefficient (x 10(-5) cm/sec) for Na (P(Na)), urea (P(urea)), and sucrose (P(sucrose)) were determined using isotopic techniques. When the bath was hypooncotic, there was (as compared with isooncotic serum) a significant decrease in net volume (38%) and net sodium (40%) flux, but no change in P(Na), P(urea), or transtubular potential; however, P(sucrose) increased significantly (78%). In experiments in which hyperoncotic bath was used, there was (compared with isooncotic serum) an increase in net volume (28%) and net sodium (30%) flux, but transtubular potential difference did not change significantly. These data demonstrated that changes in the ambient protein concentration gradient exert direct effects upon proximal tubular reabsorption. Because penetration of sucrose (an index of intercellular movement) but not urea (an index of transcellular movement) varied with changes in tubular reabsorption, it is suggested that oncotic pressure acts by altering the rate of back-leak of reabsorbate through extracellular pathways between tubular cells. It is concluded that an effect of protein concentration on reabsorption can be exerted directly across the basement membrane, without necessary interposition of the capillary bed.
PWE-155 A Bad Gut Feeling: The Long-Term Impact of Pelvic Radiotherapy on Gastrointestinal (GI) Function
Authors: A C Muls, A Lalji, H J Andreyev
Journal: Gut (2013)

<h3>Aims</h3> To identify healthcare transition models associated with positive outcomes, and review evidence regarding the optimum age of transfer and the value of existing age-appropriate services. <h3>Methods</h3> A systematic search strategy was used across multiple databases to identify systematic reviews addressing two review questions. What is the evidence for a delayed transition? What is the value of existing age–appropriate services? Reviews that were not systematic, did not cover healthcare transitions, did not concern long-term conditions, or were not reviews of primary literature were excluded. Reviews of quantitative, qualitative or mixed methods studies were included. Quality was assessed using the R-AMSTAR tool. Studies with a score below 22 were excluded. The search strategy was initially applied in April 2015 and was repeated in May 2017 to include newly published literature. <h3>Results</h3> The initial search strategy produced 2533 results with 11 systematic reviews meeting all inclusion criteria. Repeating the search criteria produced 3616 new results published between April 2015 and May 2017, with an additional 13 systematic reviews meeting all inclusion criteria. Of the 24 identified reviews, 16 reviews addressed question 1, whilst 19 reviews addressed question 2. The primary studies within these reviews included a number of interventional studies and several randomised control trials. The majority of studies which examined the optimum age of transition stated that transition time should be determined by developmental maturity, not a rigid age threshold. However, delayed transition was associated with improved outcomes. These included health-service use, clinical outcomes, reduced care gaps and patient satisfaction. Evidence from individual programmes found potential benefits from commencing transition preparedness training in early adolescence. Studies which evaluated age-appropriate services found that they were generally well-regarded by patients and often result in improved outcomes, better engagement with healthcare services or improved patient health behaviours. <h3>Conclusions</h3> This review suggests that delayed transition and dedicated age-appropriate services result in improved outcomes and increased patient satisfaction. These findings appear to be consistent across a range of long-term conditions and in a variety of healthcare systems. Further work is required to identify specific barriers and facilitators to successful healthcare transition.
774-1 On Line Assessment of Left Ventricular Function by Echocardiographic Automated Boundary Detection: Comparison with Gated Blood Pool Ventriculography
Authors: R. Tramarin, A. Zito, E. Traversi, G. Forni, D. Rossi, G. Cannizzaro, M. Pozzoli, L. Tavazzi
Journal: Journal of the American College of Cardiology (1995)
Thrombin-mediated activation of factor XI results in a thrombin-activatable fibrinolysis inhibitor-dependent inhibition of fibrinolysis.
Authors: P A Von dem Borne, L Bajzar, J C Meijers, M E Nesheim, B N Bouma
Journal: Journal of Clinical Investigation (1997)

Recently, it has been shown that Factor XI can be activated by thrombin, and that Factor XIa significantly contributes to the generation of thrombin via the intrinsic pathway after the clot has been formed. This additional thrombin, generated inside the clot, was found to protect the clot from fibrinolysis. A plausible mechanism for this inhibitory effect of thrombin involves TAFI (thrombin-activatable fibrinolysis inhibitor, procarboxypeptidase B) which, upon activation, may inhibit fibrinolysis by removing carboxy-terminal lysines from fibrin. We studied the role of Factor XI and TAFI in fibrinolysis using a clot lysis assay. The lysis time was decreased twofold when TAFI was absent, when TAFI activation was inhibited by anti-TAFI antibodies, or when activated TAFI was inhibited by the competitive inhibitor (2-guanidinoethylmercapto)succinic acid. Inhibition of either TAFI activation or Factor XIa exhibited equivalent profibrinolytic effects. In the absence of TAFI, no additional effect of anti-Factor XI was observed on the rate of clot lysis. We conclude that the mechanism of Factor XI-dependent inhibition of fibrinolysis is through the generation of thrombin via the intrinsic pathway, and is dependent upon TAFI. This pathway may play a role in determining the fate of in vivo formed clots.
Abstract LB-201: New derivatives of etoposide show promise as more potent inhibitors of cancer cell growth
Authors: Susannah Gal, Rebecca Young, Steve Slilaty, Geraldine Deliencourt-Godefroy, Jean-Charles Quirion
Journal: Cancer Research (2011)

Abstract The DNA repair enzyme Topoisomerase II (TopoII) has been recognized in the oncology field as a clinically important therapeutic target for a variety of cancers. The class of agents known as etoposides were specifically designed with this target in mind. Etoposides lacked the major problem of cardiac toxicity associated with the anthracyclines class of drugs (e.g. doxorubicin). Sunshine Biopharma has recognized that the reduced efficacy and high toxicity of etoposide are due to instability of the molecule leading to a conversion of the drug which then functions as a tubulin inhibitor rather than a TopoII inhibitor (unpublished observations). Accordingly, the company set out to develop a true TopoII inhibitor and these efforts have yielded two compounds called Adva-27a and Adva-32a. These drugs and their derivatives have been described in US Patent Application Number: 20090318675. Using cell lines derived from a variety of human cancers, Adva-27a is almost always a more potent inhibitor of cell growth compared to etoposide, and cells expressing the MDR-drug resistance protein are very sensitive to this drug. Furthermore, consistent with the literature, amplification of the TOP2α gene is associated with increased sensitivity to growth inhibition. The preliminary data show that in all but the brain tumor cell line, increased TOP2α copy number is associated with even greater percent inhibition by Adva-27a versus etoposide regardless of the tissue of origin of the tumor cell lines. This data and plans for further analysis of these drugs will be presented. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-201. doi:10.1158/1538-7445.AM2011-LB-201
Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia
Authors: Peter Nürnberg, Holger Thiele, David Chandler, Wolfgang Höhne, Michael L. Cunningham, Heide Ritter, Gundula Leschik, Karen Uhlmann, Claudia Mischung, Karen Harrop, Jack Goldblatt, Zvi U. Borochowitz, Dieter Kotzot, Frank Westermann, Stefan Mundlos, Hans-Steffen Braun, Nigel Laing, Sigrid Tinschert
Journal: Nature Genetics (2001)
THE MANIC-DEPRESSIVE AND DEMENTIA PRÆCOX PSYCHOSES: THEIR DIFFERENTIAL SYMPTOMATOLOGY
Authors: H. H. DRYSDALE
Journal: American Journal of Psychiatry (1917)

to the recent graduate, and it is indeed surprising how often he correctly "suspects" a certain psychosis.In many of the simpler forms, or in those cases which pursue a typical course early recognition is quite commonplace, but in those psychoses that develop atypically, or exhibit manifestations that are out of the ordinary, considerable confusion and perplexity prevails.
Comparative Evolutionary Analysis of Chalcone Synthase and Alcohol Dehydrogenase Loci in Arabidopsis, Arabis, and Related Genera (Brassicaceae)
Authors: Marcus A. Koch, Bernhard Haubold, Thomas Mitchell-Olds
Journal: Molecular Biology and Evolution (2000)

We analyzed sequence variation for chalcone synthase (Chs) and alcohol dehydrogenase (Adh) loci in 28 species in the genera Arabidopsis and Arabis and related taxa from tribe Arabideae. Chs was single-copy in nearly all taxa examined, while Adh duplications were found in several species. Phylogenies constructed from both loci confirmed that the closest relatives of Arabidopsis thaliana include Arabidopsis lyrata, Arabidopsis petraea, and Arabidopsis halleri (formerly in the genus Cardaminopsis). Slightly more distant are the North American n = 7 Arabis (Boechera) species. The genus Arabis is polyphyletic—some unrelated species appear within this taxonomic classification, which has little phylogenetic meaning. Fossil pollen data were used to compute a synonymous substitution rate of 1.5 × 10 substitutions per site per year for both Chs and Adh. Arabidopsis thaliana diverged from its nearest relatives about 5 MYA, and from Brassica roughly 24 MYA. Independent molecular and fossil data from several sources all provide similar estimates of evolutionary timescale in the Brassicaceae.