tbuckley/cabot-search huggingface dataset:
Clinical and Echocardiographic Determinants of Long-Term Survival After Surgical Myectomy in Obstructive Hypertrophic Cardiomyopathy
Authors: Anna Woo, William G. Williams, Richard Choi, E. Douglas Wigle, Evelyn Rozenblyum, Katie Fedwick, Samuel Siu, Anthony Ralph-Edwards, Harry Rakowski
Journal: Circulation (2005)

Surgical myectomy has been the standard treatment for patients with drug-refractory obstructive hypertrophic cardiomyopathy. The clinical and echocardiographic predictors of long-term survival and freedom from cardiovascular morbidity after myectomy have been unclear.We studied a consecutive cohort of 338 adult patients (age at operation 47+/-14 [range 18 to 77] years, 60% male) who underwent myectomy at our institution. Preoperative resting left ventricular outflow tract (LVOT) gradient was 66+/-32 mm Hg (range 5 to 158 mm Hg). Early postoperative mortality was 1.5% (5 deaths): 4 deaths occurred between 1978 and 1992, and 1 death occurred between 1993 and 2002. During long-term follow-up, 83% of patients reported an improvement to functional class I or II. The majority of patients (98%) had no resting LVOT gradient. Long-term survival was excellent, with 98+/-1% survival at 1 year, 95+/-1% at 5 years, and 83+/-3% at 10 years after myectomy. Multivariable Cox regression analysis identified 5 predictors of overall mortality: (1) age > or =50 years at surgery (hazard ratio [HR] 2.8, 95% CI 1.5 to 5.1, P=0.001), (2) female gender (HR 2.5, 95% CI 1.5 to 4.3, P=0.0009), (3) history of preoperative atrial fibrillation (HR 2.2, 95% CI 1.2 to 4.0, P=0.008), (4) concomitant CABG (HR 3.7, 95% CI 1.7 to 8.2, P=0.001), and (5) preoperative left atrial diameter > or =46 mm (HR 2.9, 95% CI 1.6 to 5.4, P=0.0008). Significant predictors of late major cardiovascular events found on multivariable analysis were (1) female gender (HR 3.3, 95% CI 2.0 to 5.4, P<0.0001), (2) history of preoperative atrial fibrillation (HR 1.9, 95% CI 1.1 to 3.3, P=0.02), and (3) preoperative left atrial diameter > or =46 mm (HR 2.5, 95% CI 1.5 to 4.3, P=0.0008).Myectomy provides excellent relief for LVOT obstruction in patients with hypertrophic cardiomyopathy. Preoperative clinical and echocardiographic variables can predict long-term outcome after myectomy.
Ian George Kelly
Authors: David Hamblen
Journal: BMJ (2004)

Consultant orthopaedic surgeon Glasgow Royal Infirmary (b Liverpool 1948; q Edinburgh 1972; MD, FRCS Ed, FRCS Glas), died from intestinal cancer on 10 August 2004.​2004.




Figure 1




Ian did his specialist training in orthopaedic surgery in Scotland and spent the rest of his career in Glasgow. He followed an academic route, commencing as a research fellow at the Western Infirmary to study gait analysis of the hip in collaboration with bioengineers at Strathclyde University. He was appointed lecturer and then became consultant senior lecturer in the university department in 1983. His special interest in surgery of the shoulder joint led to increasing national and international recognition. In 1989 he crossed the city to take up an NHS consultant post at Glasgow Royal Infirmary. Ian enjoyed Scottish country dancing and became an accomplished bagpiper. He leaves a wife, Helen, and four children.
Netprints: the next phase in the evolution of biomedical publishing
Authors: T. Delamothe, R. Smith, M. A Keller, J. Sack, B. Witscher
Journal: BMJ (1999)

> ![Graphic][1]</img> Where the mind is without fear and the head is held high; > > Where knowledge is free; > > Where the world has not been broken up into fragments by narrow domestic walls; > > Where words come out from the depth of truth; > > Where tireless striving stretches its arms towards perfection; > > Where the clear stream of reason has not lost its way into the dreary desert sand of dead habit; > > Where the mind is led forward by thee into ever-widening thought and action— > > Into that heaven of freedom, my Father, let my country awake. > > from Rabindranath Tagore's Gitanjali This week we launch clinmed.netprints.org, an electronic archive where authors can post their research into clinical medicine and health before, during, or after peer review by other agencies. Resulting from a collaboration between the BMJ Publishing Group and Stanford University Libraries, it will allow researchers to share their findings in full, for free, and as soon as their studies are complete. Articles will be screened for breaches of confidentiality and libel before we post them. After posting authors may submit them to any peer reviewed journal that will accept submissions that have appeared as electronic preprints. The list of such journals extends far beyond those of the BMJ Publishing Group and is growing daily (see box) Researchers who have retained the right to post their research results after publication in a peer reviewed journal can archive their articles here rather than on possibly more ephemeral institutional or personal websites. #### Journals accepting submissions that have appeared on preprint servers [1]: /embed/inline-graphic-1.gif
Oral Medroxyprogesterone in the Treatment of Postmenopausal Symptoms
Authors: Isaac Schiff
Journal: JAMA (1980)

A double-blind crossover study was designed to compare the effects of placebo and medroxyprogesterone acetate, 20 mg, on vasomotor flushes and blood hormones in 27 postmenopausal women. In women receiving placebo, vasomotor flushes were decreased by 25.9% during the last four weeks of treatment compared with baseline, and a further decrease of 34.5% was achieved by the last four weeks after patients were given medroxyprogesterone. In women who initially took medroxyprogesterone, there a 73.9% decline by the last four weeks in the number of vasomotor flushes. However, when these women were given placebo, an immediate worsening of their symptoms occurred. The drug produced a decline of 27% and 29% in serum levels of follicle-stimulating hormone and luteinizing hormone, respectively, while the serum prolactin level rose slightly. Thus, medroxyprogesterone can be used to treat the vasomotor flushes of postmenopausal women when estrogen use is undesirable.
Sleep disorder provides a clue to early disease detection
Authors: Eleanor Beal
Journal: Nature Reviews Neurology (2010)

research highlights neurodegenerative disease sleep disorder provides a clue to early disease detection 30 s epoch of polysomnogram showing the classic features of idiopathic rapid eye movement (reM) behavior disorder: reM sleep with increased phasic electromyographic activity in the lower limbs (channels 10-14 in black and green) as the patient was kicking.image provided by Dr alex iranzo.
VOLUNTEER MEDICAL SERVICE CORPS
Authors: Gordon M. Christine
Journal: JAMA (1918)

[Two weeks agoThe Journal(September 7, p. 845) published in Queries and Minor Notes letters and answers relative to the Volunteer Medical Service Corps. These prompted the correspondence that follows:] <h3>FROM PHILADELPHIA</h3><h3>To the Editor:</h3> —There are two things about your reference in the issue of September 7 regarding the Volunteer Medical Service Corps: one is the publication of letters over initials only of the writers without specific address, and the other is your unfavorable reference to the idea of a corps of this character. I am not in a position to know, but would regard your strictures as based on some personal or collective feeling in the matter. However, I am wearing a button and have felt happy in the thought that at my age [61] I have agreed to do any service to the government in the medical or surgical line it is commanded that I shall
Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells
Authors: Francesco Saverio Tedesco, Arianna Dellavalle, Jordi Diaz-Manera, Graziella Messina, Giulio Cossu
Journal: Journal of Clinical Investigation (2010)

Skeletal muscle damaged by injury or by degenerative diseases such as muscular dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon satellite cells, myogenic progenitors localized between the basal lamina and the muscle fiber membrane. However, other cell types outside the basal lamina, such as pericytes, also have myogenic potency. Here, we discuss the main properties of satellite cells and other myogenic progenitors as well as recent efforts to obtain myogenic cells from pluripotent stem cells for patient-tailored cell therapy. Clinical trials utilizing these cells to treat muscular dystrophies, heart failure, and stress urinary incontinence are also briefly outlined.
One Multimedia Medical World
Authors: George D. Lundberg
Journal: JAMA (1995)

Contrary to recent reports describing the pending demise of biomedical journals,<sup>1</sup>print versions of medical journals are not yet ready to go the way of the horse-drawn carriage. And to avoid an information gap for those who do not wish to receive medical information on-line, we are not abandoning our print journals and jumping into cyberspace. We are not, however, resting on our paper laurels. For many years, we have written and spoken of one medical world<sup>2</sup>—all humankind as brothers and sisters. Now we speak about serving the information needs of one medical world. We at the American Medical Association have been at this for more than 100 years. Mostly, we use print periodicals—<i>JAMA</i>, nine primary-source specialist journals, 44 secondary-source medical journals distributed worldwide in 11 languages, and<i>American Medical News</i>, the weekly medical newspaper. But it's time to extend this reach even further. Our journals
Gastric Hemostasis by Laser Phototherapy in Man
Authors: Richard M. Dwyer
Journal: JAMA (1976)

LASER energy has previously been shown to control bleeding from superficial gastric erosions in the dog. In the initial report by Goodale et al, 1 carbon dioxide laser energy was transmitted through a rigid, hollow endoscope. Subsequently, Nath et al 2 described a flexible fiberoptic delivery system through which argon laser energy could be transmitted. In 1975, Dwyer et al 3 reported the successful use of such a system to treat hemorrhage from superficial gastric erosions in dogs. This communication describes the use of argon ion laser phototherapy for the treatment of acute upper-gastrointestinal bleeding in man.  Materials and Methods  An argon ion retinal photocoagulator with a flexible fiberoptic delivery system was attached to the outside of an endoscope as previously reported. 3 The tip of the fiberoptic cable was covered by a protective cap, and the cap was equipped with two channels, one for water to wash the quartz
Lung Cancer Serum Biomarker Discovery Using Label-Free Liquid Chromatography-Tandem Mass Spectrometry
Authors: Xuemei Zeng, Brian L. Hood, Ting Zhao, Thomas P. Conrads, Mai Sun, Vanathi Gopalakrishnan, Himanshu Grover, Roger S. Day, Joel L. Weissfeld, David O. Wilson, Jill M. Siegfried, William L. Bigbee
Journal: Journal of Thoracic Oncology (2011)
Hypertension with dissecting abdominal aortic aneurysm.
Authors: R A Bradbrook, A J Marshall, P L Spreadbury
Journal: BMJ (1974)

23already reported for F.D.P. and again the rise of C3 and F.D.P. excretion tended to coincide.Until now little attention has been given to the excretion of C3 in the urine of patients with glomerulonephritis.Indeed the published reports (Lange and Wenk, 1954; Lagrue et al., 1969) have been concerned with establishing that the low serum C3 concentrations have not been produced by excessive urinary C3 loss.Recently C3 has been shown to be present in the urine of patients with proliferative glomerulonephritis and after renal transplantation using the relatively insensitive radial immunodiffusion assay (Hoq et al., 1974).Our preliminary results indicate that C3 excretion occurs often in patients with glomerulonephritis and suggest that further studies may be useful.We shoud like to thank our colleagues Professor M. Lessof, Dr. Chisholn Ogg, and Dr. Cyril Chantler for permission to study many of their patients.Dr. David Turner evaluated many of the biopsy specimens,
P676 SINGNIFICANT REDUCTION IN END-STAGE LIVER DISEASE BURDEN THROUGH NATIONAL CHRONIC VIRAL HEPATITIS THERAPY PROGRAM IN TAIWAN
Authors: C.-J. Chen, C.-J. Chiang, Y.-W. Yang, J.-D. Chen, H.-I. Yang, M.-H. Lee, S.-L. You, M.-S. Lai
Journal: Journal of Hepatology (2014)
Neoplastic involvement of granulocytic lineage, not granulocytic-monocytic, monocytic, or erythrocytic lineage, in a patient with chronic neutrophilic leukemia case report
Authors: Kohsuke Yanagisawa, Hideki Ohminami, Masateru Sato, Kiyonori Takada, Hitoshi Hasegawa, Masaki Yasukawa, Shigeru Fujita
Journal: American Journal of Hematology (1998)

Chronic neutrophilic leukemia (CNL) is a very rare myeloproliferative disorder. To determine the neoplastic origin of CNL, morphological and cytogenetical studies were made of colonies derived from hematopoietic progenitors of a patient with CNL. The patient's hematopoietic progenitors spontaneously formed colonies consisting of mature granulocytes, and cytogenetical study of the colonies indicated chromosome abnormalities identical to those in the patient's bone marrow cells. Analysis of colonies consisting of granulocytes and macrophages, macrophages, or erythrocytes disclosed a normal karyotype. These results demonstrated that the neoplastic process in this patient with CNL originated in hematopoietic progenitors capable of differentiating only into granulocytes, and not granulocytes and monocytes, monocytes, or erythrocytes. Am. J. Hematol. 57:221–224, 1998. © 1998 Wiley-Liss, Inc.
Type 2 Diabetes Prevalence in Asian Subjects
Authors: Hirohito Sone, Sachiko Mizuno, Yasushi Ohashi, Nobuhiro Yamada
Journal: Diabetes Care (2004)

McNeely and Boyko (1) recently demonstrated that the BMI-adjusted odds ratio for type 2 diabetes in Asian Americans was 1.6 times that of white Americans. Interestingly, there was no significant difference between the preadjusted values of these two ethnic groups. As the BMI adjustment only affected Asians, it is possible that the influence of BMI on the development of type 2 diabetes is more potent in Asians than in other ethnic …
Bilateral hip osteonecrosis: influence of hip size on outcome
Authors: P. Hernigou
Journal: Annals of the Rheumatic Diseases (2000)

To measure the volume of osteonecrosis in 30 patients with disease in both hips (one side with collapse and the other without at Ficat stage I).The volume of the osteonecrosis was measured by magnetic resonance imaging.The progression to collapse was influenced by the size of the lesion in each patient. The first collapsed hip was that with the largest volume of osteonecrosis.The volume of the osteonecrotic lesion on the second hip (stage I without collapse) is a good predictor of the time to collapse of this second hip.
Prevalence, Treatment, and Outcomes of Coexistent Ocular Surface Squamous Neoplasia and Pterygium
Authors: Patrick Oellers, Carol L. Karp, Anoop Sheth, Andrew A. Kao, Amany Abdelaziz, Jared L. Matthews, Sander R. Dubovy, Anat Galor
Journal: Ophthalmology (2012)
Active specific immunotherapy in patients with melanoma. A clinical trial with mouse antiidiotypic monoclonal antibodies elicited with syngeneic anti-high-molecular-weight-melanoma-associated antigen monoclonal antibodies.
Authors: A Mittelman, Z J Chen, T Kageshita, H Yang, M Yamada, P Baskind, N Goldberg, C Puccio, T Ahmed, Z Arlin
Journal: Journal of Clinical Investigation (1990)

In two clinical trials the mouse antiidiotypic monoclonal antibody (MAb) MF11-30, which bears the internal image of human high-molecular-weight-melanoma-associated antigen (HMW-MAA) was administered by subcutaneous route without adjuvants to patients with stage IV malignant melanoma on day 0, 7, and 28. Additional injections were administered if anti-antiidiotypic antibodies were not found or their titer decreased. In the first phase I trial with 16 patients the initial dose was 0.5 mg per injection and escalated to 4 mg per injection. Neither toxicity nor allergic reactions were observed despite the development of anti-mouse Ig antibodies. Minor responses were observed in three patients. In a second clinical trial MAb MF11-30 was administered to 21 patients at a dose of 2 mg per injection, since this dose had been shown in the initial study to be effective in inducing anti-antiidiotypic antibodies. Two patients were inevaluable; in the remaining 19 patients, the average duration of treatment was 34 wk. In this trial as well, neither toxicity nor allergic reactions were observed. 17 of the 19 immunized patients increased the levels of anti-mouse Ig antibodies and 16 developed antibodies that inhibit the binding of antiidiotypic MAb MF11-30 to the immunizing anti-HMW-MAA MAb 225.28. One patient increased the level of anti-HMW-MAA antibodies. One patient achieved a complete remission with disappearance of multiple abdominal lymph nodes for a duration of 95 wk. Minor responses were observed in three patients. These results suggest that mouse antiidiotypic MAb that bear the internal image of HMW-MAA may be useful reagents to implement active specific immunotherapy in patients with melanoma.
Nuclear-Encoded, Plastid-Targeted Genes Suggest a Single Common Origin for Apicomplexan and Dinoflagellate Plastids
Authors: Naomi M. Fast, Jessica C. Kissinger, David S. Roos, Patrick J. Keeling
Journal: Molecular Biology and Evolution (2001)

The phylum Apicomplexa encompasses a large number of intracellular protozoan parasites, including the causative agents of malaria (Plasmodium), toxoplasmosis (Toxoplasma), and many other human and animal diseases. Apicomplexa have recently been found to contain a relic, nonphotosynthetic plastid that has attracted considerable interest as a possible target for therapeutics. This plastid is known to have been acquired by secondary endosymbiosis, but when this occurred and from which type of alga it was acquired remain uncertain. Based on the molecular phylogeny of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) genes, we provide evidence that the apicomplexan plastid is homologous to plastids found in dinoflagellates—close relatives of apicomplexa that contain secondary plastids of red algal origin. Surprisingly, apicomplexan and dinoflagellate plastid-targeted GAPDH sequences were also found to be closely related to the plastid-targeted GAPDH genes of heterokonts and cryptomonads, two other groups that contain secondary plastids of red algal origin. These results address several outstanding issues: (1) apicomplexan and dinoflagellate plastids appear to be the result of a single endosymbiotic event which occurred relatively early in eukaryotic evolution, also giving rise to the plastids of heterokonts and perhaps cryptomonads; (2) apicomplexan plastids are derived from a red algal ancestor; and (3) the ancestral state of apicomplexan parasites was photosynthetic.
B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4
Authors: Gordon J. Freeman, Vassiliki A. Boussiotis, Anukanth Anumanthan, Gregory M. Bernstein, Xiao-Yen Ke, Paul D. Rennert, Gary S. Gray, John G. Grlbben, Lee M. Nadler
Journal: Immunity (1995)
The Prophylaxis of Tetanus.
Authors: Thomas G. Davis
Journal: JAMA (1904)

Bridgeton, N. J., June 18, 1904. <h3>To the Editor:</h3> —An article inThe Journal, June 18, regarding the prophylaxis of tetanus leads me to suggest a method of cleansing all punctured wounds by nails and splinters, as well as those caused by Fourth of July foolish exuberance. For years I have used hydrogen dioxid solutions diluted with sterile water made alkaline by sodium bicarbonate, or have used them alternately. As the tetanus bacillus is anaërobic, theoretically the oxygen given off would be deterent; secondly, I have found that if used freely all foreign matter will be removed, usually without curetting, although this may be done if necessary. Caustics are unnecessary, often harmful. A more sensible packing would be loose gauze, with glycerin to promote exosmosis and drainage. The wound should be cleansed with hydrogen dioxid several times daily.
Expression of carbonic anhydrase 9 at the invasion front of gastric cancers
Authors: J Chen
Journal: Gut (2005)

<b>Background:</b> Carbonic anhydrase IX (MN/Ca9) catalyses the reversible metabolism of carbon dioxide to carbonic acid and has also been linked to malignant transformation and hypoxia in various cancers. <b>Aims:</b> To assess the expression and biological role of Ca9 in gastric cancer. <b>Methods:</b> Using gastric cancer cell lines and tissues, we studied expression of Ca9 by western blot analysis, immunohistochemistry, and polymerase chain reaction. Biological changes after Ca9 transfection and after treatment with 5′-azadeoxycytidine were also analysed in cancer cell lines. <b>Results:</b> Non-cancerous tissues strongly expressed Ca9 with membranous localisation. In contrast, Ca9 expression was frequently lost in gastric cancers (p&lt;0.001). However, gastric cancers that retained Ca9 expression in cancer cells exhibited a shorter postoperative survival (p = 0.028). In vitro analysis revealed that loss of Ca9 expression in gastric cancer cell lines was restored after treatment with 5′-azadeoxycytidine and was associated with increased invasion (p&lt;0.01). Moreover, AGS cells transfected with Ca9 exhibited significantly increased cell proliferation (p&lt;0.05). <b>Conclusions:</b> A subgroup of gastric cancers retain Ca9 expression in cancer cells at the invasion front. While loss of Ca9 expression is regulated in part by methylation, re-expression of Ca9 is associated with increased invasion, supporting the hypothesis that increased Ca9 expression may contribute to invasion and thus advanced disease and tumour progression in a subset of gastric cancers.
Tissue Mediators in the Genesis of Experimental Shock
Authors: Benjamin W. Zweifach
Journal: JAMA (1962)

SHOCK, as it is produced in the laboratory, usually involves a clearly identified set of initiating circumstances which range from hemorrhage, bowel ischemia, muscle trauma, to overt infection. For this reason, the general course of the syndrome is much more easily defined in terms of specific factors than is the shock state in man. Once shock is established, numerous contributory factors become involved with time and progressively undermine the capacity to respond to restorative measures. It is this aspect of the problem which continues to be controversial. The fact that biologically active agents appear in the tissues and in the blood stream coincidentally with the development of irreversibility, strongly suggests that the unremitting deterioration of cardiovascular function characteristic of severe, protracted shock may be due to the untoward action of one or more of these agents.  A logical first step in analyzing this aspect of the problem would be to
Threat of war is affecting mental health of Iraqi children, says report
Authors: J. Clark
Journal: BMJ (2003)

The vast majority of Iraq's 13million children will be affected if the war between Iraq and the West goes ahead, a report released by a Canadian led team of health experts concludes.

The report, based on a humanitarian fact finding mission in Iraq that included interviews with 100 families in Baghdad, Karbala, and Basra in January 2003, warns that Iraqi children are at grave risk of starvation, disease, death, and psychological trauma.

Casualties are predicted to be in the tens of thousands in the …
Inadvertent Ligation of the Left Pulmonary Artery Instead of Patent Ductus Arteriosus Noninvasive Diagnosis by Pulmonary Perfusion Imaging
Authors: JOSEPH A. ORZEL, MICHELE P. MONACO
Journal: Clinical Nuclear Medicine (1986)

Pulmonary perfusion scintigraphy was used to noninvasively evaluate a neonate four days after attempted surgical closure of a large patent ductus arteriosus (PDA). No perfusion to the left lung was seen, suggesting inadvertent ligation of the left pulmonary artery (PA). This was confirmed by cardiac catheterization and reoperation. Radionuclide pulmonary perfusion imaging is an ideal noninvasive technique for evaluating pulmonary perfusion in neonates after complicated thoracic surgery.