tbuckley/cabot-search huggingface dataset:
The Battered Child
Authors: S. M. Rabson
Journal: JAMA (1968)

An early novel of Werfel was called<i>Not the Murderer, the Murdered Is Guilty</i>. Thus, the battered or neglected child is guilty of the crimes committed against it because it exists, and in a world apart from those who mistreat it. So it is that the child can serve as whipping-boy for the pains, disappointments, and maladjustments of its elders. Its very inability to defend itself would seem to increase the wrath of the delinquent adult or older child; surely, part of the attacker's vigor would be dissipated were the child's attempts at self-protection at all effective. It was Kempe who is credited with proposing the term, "the battered child syndrome," only seven years ago. The volume treats the problem from several angles: historical demographic, medical (including radiologic and pathologic anatomic), psychiatric, social, and legal. Most physicians will find Helfer's chapter, "The Responsibility and Role of the Physician," the most
Relationship Between Cardiac Rehabilitation and Long-Term Risks of Death and Myocardial Infarction Among Elderly Medicare Beneficiaries
Authors: Bradley G. Hammill, Lesley H. Curtis, Kevin A. Schulman, David J. Whellan
Journal: Circulation (2009)

For patients with coronary heart disease, exercise-based cardiac rehabilitation improves survival rate and has beneficial effects on risk factors for coronary artery disease. The relationship between the number of sessions attended and long-term outcomes is unknown.In a national 5% sample of Medicare beneficiaries, we identified 30 161 elderly patients who attended at least 1 cardiac rehabilitation session between January 1, 2000, and December 31, 2005. We used a Cox proportional hazards model to estimate the relationship between the number of sessions attended and death and myocardial infarction (MI) at 4 years. The cumulative number of sessions was a time-dependent covariate. After adjustment for demographic characteristics, comorbid conditions, and subsequent hospitalization, patients who attended 36 sessions had a 14% lower risk of death (hazard ratio [HR], 0.86; 95% confidence interval [CI], 0.77 to 0.97) and a 12% lower risk of MI (HR, 0.88; 95% CI, 0.83 to 0.93) than those who attended 24 sessions; a 22% lower risk of death (HR, 0.78; 95% CI, 0.71 to 0.87) and a 23% lower risk of MI (HR, 0.77; 95% CI, 0.69 to 0.87) than those who attended 12 sessions; and a 47% lower risk of death (HR, 0.53; 95% CI, 0.48 to 0.59) and a 31% lower risk of MI (HR, 0.69; 95% CI, 0.58 to 0.81) than those who attended 1 session.Among Medicare beneficiaries, a strong dose-response relationship existed between the number of cardiac rehabilitation sessions and long-term outcomes. Attending all 36 sessions reimbursed by Medicare was associated with lower risks of death and MI at 4 years compared with attending fewer sessions.
Qhubeka! Moving forward with SASMA
Authors: Jon Patricios, Glen Hagemann
Journal: British Journal of Sports Medicine (2013)

Featured on the cover of this month's BJSM , Team MTN Qhubeka combines experienced and emerging continental riders from Germany, Spain, Lithuania and Italy, with home-grown African talent from South Africa, Ethiopia, Eritrea and Ruanda. Arguably, there is no other cycling team that better represents genetic diversity.

Uniquely, this elite cycling team also has a large community focus. It works closely with the Qhubeka foundation (http://www.qhubeka.org) which donates bicycles to communities who are environmentally conscious under the mantra ‘Mobilising kids with bikes’ a sort of rural Exercise is Medicine initiative!

Team MTN Qhubeka is far from being another African handout story. While still having to earn its stripes to compete in the Grand Tours, success in several of Europe's Spring Classic races has set the cat among the pelaton's pigeons. Songezo Jim, an orphan from the townships of Cape Town, became the first black African to participate in the longest 1-day Classic on the racing calendar, the Milan Sanremo,1 a race won by team captain Gerald Ciolek. Ciolek also had a podium finish in stage 2 of the 7-day Tirreno Adriatico across …
Up-regulation of CYP26A1 in Adenomatous Polyposis Coli–Deficient Vertebrates via a WNT-Dependent Mechanism: Implications for Intestinal Cell Differentiation and Colon Tumor Development
Authors: Dawne N. Shelton, Imelda T. Sandoval, Annie Eisinger, Stephanie Chidester, Anokha Ratnayake, Chris M. Ireland, David A. Jones
Journal: Cancer Research (2006)

Abstract Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene seem to underlie the initiation of many colorectal carcinomas. Loss of APC function results in accumulation of β-catenin and activation of β-catenin/TCF–dependent transcription. Recent studies have implicated APC in controlling retinoic acid biosynthesis during normal intestinal development through a WNT-independent mechanism. Paradoxically, however, previous studies found that dietary supplementation of ApcMIN mice with retinoic acid failed to abrogate adenoma formation. While investigating the above finding, we found that expression of CYP26A1, a major retinoic acid catabolic enzyme, was up-regulated in ApcMIN mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of apcmcr mutant zebrafish embryos. Mechanistically, cyp26a1 induction following apc mutation is dependent on WNT signaling as antisense morpholino knockdown of tcf4 or injection of a dnLEF construct into apcmcr mutant zebrafish suppressed expression of cyp26a1 along with known WNT target genes. In addition, injection of stabilized β-catenin or dnGSK3β into wild-type embryos induced cyp26a1 expression. Genetic knockdown or pharmacologic inhibition of cyp26a1 in apcmcr mutant zebrafish embryos rescued gut differentiation defects such as expression of intestinal fatty acid–binding protein and pancreatic trypsin. These findings support a novel role for APC in balancing retinoic acid biosynthesis and catabolism through WNT-independent and WNT-dependent mechanisms. (Cancer Res 2006; 66(15): 7571-7)
Seborrhoeic Dermatitis and Acne Vulgaris
Authors: G. B. Mitchell-Heggs
Journal: BMJ (1951)

A seborrhoeic subject is born with a skin that has a tendency to produce an excess of sebum, and in some cases this is complicated by a periodic diminution of its resistance to infection by bacteria, yeasts, and fungi.Such a skin is not necessarily in itself pathological.The seborrhoeic state is a constitutional trait conditioned by the endocrine make-up of the patient under genetic influences.Many seborrhoeic subjects can be recognized by the dirty yellow or grey and greasy skin of the face.The pilosebaceous orifices are patulous, particularly over the alae nasi, temples, and concha of the ear.The patient may not claim that his skin is greasy and he may even complain that it is too " dry."This is due to the presence of fine greasy scales in the nasolabial folds and some- times over most of the facial skin.Similar scales are found on the eyebrows, around many eyelashes, over the temples, aind on the hairy areas of the chest, the axillae, and the pubes.There is nearly always some
Abstract 17686: Syndecan-4 Proteoliposomes Enhance FGF-2 Induced Proliferation, Migration and Neovascularization of Ischemic Muscle
Authors: Subhamoy Das, Eugene Jang, Hassan Albadawi, Michael T Watkins, Elazer R Edelman, Aaron B Baker
Journal: Circulation (2011)

Objectives: Inducing angiogenesis for the treatment of ischemia is an appealing therapeutic strategy for patients in whom traditional treatment modalities cannot be performed or are ineffective. While therapeutic angiogenesis holds great promise for treating patients with ischemia, none of the current methods has found success in clinical trials. Methods: Here, we developed a novel method for improving the biological activity of FGF-2 by co-delivering the growth factor with a liposomally embedded co-receptor, syndecan-4. We compared this method of growth factor delivery to FGF-2 alone in in-vitro experiments using a wound healing assay of cell migration, thymidine incorporation for proliferation and a tube formation assay for angiogenic differentiation. We also created hind limb ischemia in rats through femoral artery ligation. Following induction of ischemia, we delivered FGF-2, control or FGF-2 and syndecan-4 proteoliposomes to the rats using an osmotic pump and measure revascularization by Laser Doppler imaging, microCT and histological analysis. Results: Syndecan-4 proteoliposomes significantly increased endothelial cell growth, migration and tube formation. In-vivo treatment of rats with hind limb ischemia demonstrated increased revascularization in response to FGF-2 with co-delivery of syndecan-4 proteoliposomes. Laser Doppler imaging (A) showed that syndecan-4 proteoliposomes lead to a nearly complete resolution of ischemia by 7 days whereas FGF-2 alone did not resolve the ischemia by 16 days of treatment (B). This result was confirmed by histological analysis (C) and microCT based arterial reconstruction. Conclusion: Taken together, these results support that liposomal delivery of syndecan-4 is an effective means to improving the therapeutic potential of using growth factors to achieve therapeutic neovascularization of ischemic tissue.
US Global Health Strategy
Authors: Jean-Paul Chretien
Journal: JAMA (2011)

LAST YEAR, PRESIDENT OBAMA SIGNED A POLICY DIRECtive on global development, the first by a US president. It provides a common framework for the US government, emphasizing economic growth as “the only sustainable way to accelerate development and eradicate poverty.” Its health pillar is the $63 billion Global Health Initiative, launched in 2009. The initiative builds on existing programs, such as the President’s Emergency Plan for AIDS Relief, and increases support for maternal and child health, family planning, and nutrition programs. The initiative targets problems that impede development in the poorest countries. But even there, new health threats are arising with economic growth. The United States needs a new, forward-looking global health strategy that sustains progress against traditional priorities while confronting emerging impediments to global development.
Nonrandom Distribution of N-myc Oncogene Genotypes in Neuroblastoma
Authors: P. G. Waber, A. M. Bowcock, O. Arencibia-Mireles, P. D. Nisen
Journal: JNCI Journal of the National Cancer Institute (1991)

The distributions of Pvu II and Sph I alleles of the N-myc oncogene (also known as MYCN) were studied in a series of normal individuals and pediatric patients with solid tumors. In the case of Pvu II, where the polymorphic site is located 3‘ of the gene, the frequencies of the allele were 0.27 (11–kilobase fragment) and 0.73 (8–kilobase fragment) in 43 unrelated normal Caucasians. The frequencies of the allele were similar in 40 non-N-myc-amplified neuroblastomas, 47 Wilms’ tumors, and 31 other pediatric tumors. In these cases, the genotypes were in Hardy-Weinberg equilibrium. In 18 N-myc-amplified neuroblastomas, however, the observed genotype frequencies deviated from Hardy-Weinberg equilibrium (P<.005). Similar observations were made with and Sph I restriction fragment length polymorphism where the polymorphic site is located in intron 2. The differences between amplified and nonamplified neuroblastomas suggest a possible involvement of sequences at or near N-myc in the progression of tumors where the N-myc gene is amplified. [J Natl Cancer Inst 83: 1085–1088, 1991]
169 EARLY EVALUATION OF HISTOLOGICAL MARKERS OF FIBROSIS AND CELLULAR PROLIFERATION IN LIVER TRANSPLANT PATIENTS WITH HCV RECURRENCE
Authors: L. Mensa, Z. Mariño, G. Crespo, S. Lens, R. Miquel, J. Carrion, S. Perez-del-Pulgar, X. Forns, M. Navasa
Journal: Journal of Hepatology (2013)
P1-11-09: Effects of a Multidisciplinary Breast Cancer Clinic in an Appalachian Based Medical Center.
Authors: JA Ingham, DK Cremeans, SL Daugherty, RC Myhand, WE Sever
Journal: Cancer Research (2011)

Abstract Background: Adena Health System is a not for profit 250 bed institution that provides health care for a 13 county region in southeast, Appalachia Ohio. Access to health care in rural setting is an ongoing challenge. Several barriers to health care access affect this region. Socioeconomic burden and lack of higher education are two of the most dominant barriers. The age-adjusted beast cancer rates are 5.3% higher in the Appalachian region and the stage at presentation is more advanced. In December of 2009, we held our first Multidisciplinary Breast Cancer Clinic (MDBCC). The goal of the MDBCC is to facilitate prompt diagnosis and effective treatment. The MDBCC is staffed by a team of physicians consisting of surgeons, medical oncologists, and radiation oncologists. The team meets with the patient in a one on one setting. That same day the patients are discussed by the team with input from pathology and radiology in order to tailor a treatment plan specifically for each patient. After the conference, the recommendations are discussed with the patient before treatment is initiated. Material and Methods: In a retrospective review, we evaluated the effect of a MDBCC on days to diagnosis, days from diagnosis to treatment, percentage of patients receiving neoadjuvant chemotherapy, and stage at diagnosis. Since December 2009, there have been over 90 breast cancer patients evaluated in the MDBCC. We randomly selected 60 breast cancer patients treated prior to MDBCC between 2008–09 and 66 patients evaluated at the MDBCC between December 2009–2011 from the tumor registry database. Results: The average number of days to diagnosis pre-MDBCC was 15.5 days as compared to 4 days post-MDBCC. In 2008–09, the average days to treatment (pathology result to a-port placement, surgery or chemotherapy) was 18 days as compared to 12 days post-MDBCC. The percentage of patients receiving neoadjuvant chemotherapy has not changed significantly, however, there is an upward trend approaching statistical significance (10% per-MDBCC vs. 12% post-MDBCC). The stage at presentation has not changed significantly since the start of the MDBCC. Discussion: The development of the MDBCC has proven to be a successful team oriented approach to breast cancer diagnosis and treatment. Time to diagnosis and initiation of treatment has improved. Providing patients with access to multiple specialists and forming a treatment plan the same day improves quality of care and lessens economic burden. The MDBCC is clearly feasible and particularly suited to the rural hospital setting. System wide, we hope to see a decrease in the stage at presentation and are confident based upon our current data that this in a realistic goal. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P1-11-09.
The p53 mRNA-Mdm2 Interaction Controls Mdm2 Nuclear Trafficking and Is Required for p53 Activation following DNA Damage
Authors: Madhavsai Gajjar, Marco M. Candeias, Laurence Malbert-Colas, Anne Mazars, Jun Fujita, Vanesa Olivares-Illana, Robin Fåhraeus
Journal: Cancer Cell (2012)
Role of Complement Factor H I62V and Age-Related Maculopathy Susceptibility 2 A69S Variants in the Clinical Expression of Polypoidal Choroidal Vasculopathy
Authors: Yoichi Sakurada, Takeo Kubota, Mitsuhiro Imasawa, Fumihiko Mabuchi, Yasushi Tateno, Naohiko Tanabe, Hiroyuki Iijima
Journal: Ophthalmology (2011)
Authors' Response to Hockey and Reidak
Authors: Julio Licinio
Journal: PLoS Medicine (2006)

Because of the nature of the analysis used in this study [1], no conclusion is possible.There are plenty of examples in the literature demonstrating the "ecological fallacy".Studies such as this have very little utility other than to generate hypotheses.I tend to think that this association is a marker for greater recognition and treatment for depression.However, it's a brave epidemiologist who would draw any conclusions at all from an ecological association such as this where the outcome is relatively rare.
806-1 Pattern of cardiac isoenzyme elevation in probable smallpox associated myocarditis
Authors: Robert E Eckart, Dimitri C Cassimatis, John E Atwood, Suzanne S Love, Charles L Campbell, Wayne Scott, Renata J.M Engler, Limone C Collins, Mark K Arness, James R Riddle, John D Grabenstein
Journal: Journal of the American College of Cardiology (2004)
St John's wort causes most drug interactions, finds review
Authors: L. Anekwe
Journal: BMJ (2012)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following St John’s wort causes most drug interactions, finds review Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
On the trail of genetic culprits in Williams syndrome
Authors: M Keating
Journal: Cardiovascular Research (1997)

Time for primary review 21 days.

In times past—in point of fact, not very long ago: only in the years after the genetic code was deciphered—the genetic basis of certain human diseases could only be extrapolated from knowledge of biochemical correlates. A critical enzyme was missing, for example, as in phenylketonuria, or a defective hemoglobin resulted in sickle-cell anemia. Determining the DNA sequence of a defective gene was a worthwhile exercise though, because if the basis for a disorder could be identified at the coding level, investigators might be able to devise novel approaches to prevention or treatment. But for hundreds, even thousands, of heritable disorders, not to speak of common and apparently sporadic illnesses, first causes remained mysterious; with no known protein culprit, then, how could the responsible (gene)s be discovered and the physiological consequences of mutations be evaluated?

One solution—‘molecular genetics’, a major advance in molecular biology, using recombinant DNA technology to map the human genome with anonymous (non-gene) DNA markers—has gained astonishing speed within the past 15 years [1]. Localization of markers—now available in thousands—to chromosomes permits investigators to track inherited diseases in pedigrees according to linkage (i.e., co-inheritance) of a defective allele to a marker of known location [2]. As regards cardiovascular diseases, the linkage approach led to the mapping of three loci that can carry mutations responsible for long QT syndrome, on chromosomes 11p15.5, 7q35–36, and 3p21–24, respectively [3–5]. Once the site on a chromosome is determined, techniques of manipulating fragments of DNA come into play until a specific gene in the region can be shown to contain abnormalities in structure or sequence in affected family members as compared to normal individuals. Using this strategy, known as ‘positional cloning’, we eventually identified the LQT genes on 7q as HERG , a putative …
Polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs and related environmental compounds: biological markers of exposure and effects.
Authors: G Talaska, P Underwood, A Maier, J Lewtas, N Rothman, M Jaeger
Journal: Environmental Health Perspectives (1996)

Lung cancer caused by polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs and related environmental agents is a major problem in industrialized nations. The high case-fatality rate of the disease, even with the best supportive treatment, underscores the importance of primary lung cancer prevention. Development of biomarkers of exposure and effects to PAHs and related compounds is now underway and includes measurement of urinary metabolites of specific PAHs as well as detection of protein and DNA adducts as indicators of effective dose. Validation of these markers in terms of total environmental dose requires that concurrent measures of air levels and potential dermal exposure be made. In addition, the interrelationships between PAH biomarkers must be determined, particularly when levels of the marker in surrogate molecules (e.g., protein) or markers from surrogate tissues (e.g., lymphocyte DNA) are used to assess the risk to the target organ, the lung. Two approaches to biomarker studies will be reviewed in this article: the progress made using blood lymphocytes as surrogates for lung tissues and the progress made developing noninvasive markers of carcinogen-DNA adduct levels in lung-derived cells available in bronchial-alveolar lavage and in sputum. Data are presented from studies in which exfoliated urothelial cells were used as a surrogate tissue to assess exposure to human urinary bladder carcinogens in occupational groups.
Scintigraphic Manifestation of Iliotibial Band Injury in an Endurance Athlete
Authors: JOHN F. ROCKETT, H LYNN MAGILL, MOHAMMED MOINUDDIN, JOHN S. BUCHIGNANI
Journal: Clinical Nuclear Medicine (1991)

The scintigraphic appearance of an overuse injury at the insertion of the iliotibial band is described. This injury was depicted on three-phase bone scintigraphy as focally increased radionuclide concentration in the anterolateral tibial condyle (lateral tibial tubercle) where the iliotibial band inserts. Overuse injuries involving the insertion of the iliotibial band are uncommon and are not to be confused with a stress fracture or other bony lesion involving the lateral tibial condyle.
Carl Ludwig and His Pupils
Authors: ERIC NEIL
Journal: Circulation Research (1961)

HomeCirculation ResearchVol. 9, No. 5Carl Ludwig and His Pupils Free AccessResearch ArticlePDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyRedditDiggEmail Jump toFree AccessResearch ArticlePDF/EPUBCarl Ludwig and His Pupils ERIC NEIL ERIC NEILERIC NEIL Originally published1 Sep 1961https://doi.org/10.1161/01.RES.9.5.971Circulation Research. 1961;9:971–978FootnotesReprinted from Middlesex Hospital Journal 59: 40, 1959 Previous Back to top Next FiguresReferencesRelatedDetails September 1, 1961Vol 9, Issue 5Article InformationMetrics Download: 110 © 1961 American Heart Association, Inc.https://doi.org/10.1161/01.RES.9.5.971 Originally publishedSeptember 1, 1961 PDF download Advertisement
ADVANCES IN DIAGNOSIS AND TREATMENT OF SURGICAL PULMONARY DISEASE
Authors: James W. Nixon
Journal: JAMA (1952)

Although the majority of thoracic diseases that are potentially surgical come within the scope of the thoracic surgeon, it is evident to all practitioners that lesions of the chest that are amenable to surgical therapy must be recognized early. Obviously, proper care of the patient with chest disease cannot be carried out otherwise. Since the limit of this paper does not permit discussion of the diagnosis and treatment of chest disease in detail, consideration will be given only to some of the more recent advances in management of those lesions of the lung, pleura, and tracheobronchial tree that are frequently encountered by the surgeon and are of particular interest to the medical profession as a whole.  CARCINOMA OF LUNG  Diagnostic methods for the detection of carcinoma of the lung have been perfected to such a degree that one can expect a positive diagnosis in approximately 85% of the cases. The
Intravenous injection of a foamy virus vector to correct canine SCID-X1
Authors: Christopher R. Burtner, Brian C. Beard, Douglas R. Kennedy, Martin E. Wohlfahrt, Jennifer E. Adair, Grant D. Trobridge, Andrew M. Scharenberg, Troy R. Torgerson, David J. Rawlings, Peter J. Felsburg, Hans-Peter Kiem
Journal: Blood (2014)