tbuckley/cabot-search huggingface dataset:
P95 EXPRESSIONS OF MICRORNAS DIFFER BETWEEN CIRRHOTIC AND TUMOUR-SURROUNDING CIRRHOTIC LIVER AS WELL AS BETWEEN HEPATOCELLULAR CARCINOMA AND FOCAL NODULAR HYPERPLASIA
Authors: K. Schlachter, B. Gyöngyösi, M. Gyugos, G. Lendvai, K. Baghy, Z. Schaff, A. Kiss
Journal: Journal of Hepatology (2014)
Drug, Vaccine Research Target Avian Flu
Authors: Tracy Hampton
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sodium Bicarbonate Administration During Cardiac Arrest
Authors: Eric E. Harrison
Journal: JAMA (1976)

To the Editor.—  We read with interest the article by Bishop and Weisfeldt (235:506, 1976). The statement is made that By providing adequate ventilation, in the absence of preexisting acidosis, arterial pH can be maintained within reasonable limits for a considerable period during resuscitation without the addition of buffers. Biochemical data is advanced to substantiate this conclusion. However, the endpoint of the titration should not be an acceptable arterial pH, but the ultimate successful resuscitation of the patient and his continued survival. The authors do not present survival data on the animals in the experiment or on the human subjects. It would be very interesting to know if the seven dogs resuscitated without the use of sodium bicarbonate with constant volume ventilation and closed chest massage were successfully defibrillated and survived in spite of a rising plasma level of potassium.  Through a paramedical mobile coronary care system operated by a
Bacterial Cultures for Cystitis
Authors: John A. Washington
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 March 1990Bacterial Cultures for CystitisJohn A. Washington, MDJohn A. Washington, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-5-387 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:In their recent review on the diagnosis and treatment of urinary tract infections in women, Johnson and Stamm (1) have raised some difficult, if not self-contradictory, issues. Previous studies by Stamm and colleagues (2) of acutely dysuric young women, most of whom were seen at the University of Washington Student Health Center, established the fact that (in carefully collected urine specimens)Escherichia coli, Staphylococcus saprophyticus, andProteus mirabilisin the order of magnitude of 102to 104cfu/mL are clinically significant. This observation has led Johnson and Stamm (1) to recommend that clinicians encourage their clinical laboratory...References1. JohnsonStamm JW. Urinary tract infections in women: diagnosis and treatment. Ann Intern Med. 1989;111:906-17. LinkGoogle Scholar2. StammCountsRunningFihnTurckHolmes WGKSMK. Diagnosis of coliform infections in acutely dysuric women. N Engl J Med. 1982;307:463-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGuidelines for urinary tract infections. Rationale for a separate strata for patients with “low-count” bacteriuriaBacterial Cultures for CystitisJames R. Johnson, MD, Walter E. Stamm, MD 1 March 1990Volume 112, Issue 5Page: 387-388KeywordsBacterial culturesClinical laboratoriesCystitisEscherichia coliStaphylococcus saprophyticusUrine Issue Published: 1 March 1990 PDF downloadLoading ...
Amount of Hispanic Youth Exposure to Food and Beverage Advertising on Spanish- and English-Language Television
Authors: Frances Fleming-Milici, Jennifer L. Harris, Vishnudas Sarda, Marlene B. Schwartz
Journal: JAMA Pediatrics (2013)

IMPORTANCE Exposure to large numbers of television advertisements for foods and beverages with little or no nutritional value likely contributes to poor diet among youth.Given higher rates of obesity and overweight for Hispanic youth, it is important to understand the amount and types of food advertising they view.OBJECTIVE To quantify the amount of food and beverage advertising viewed by Hispanic youth on Spanish-and English-language television and compare it with the amount of food and beverage advertising viewed by non-Hispanic youth.DESIGN, SETTING, AND PARTICIPANTS Data on gross rating points that measured advertising viewed on national broadcast and cable television in 2010 using a Nielsen panel of television-viewing households of Hispanic and non-Hispanic preschoolers (2-5 years), children (6-11 years), and adolescents (12-17 years). MAIN OUTCOMES AND MEASURES Food and beverage television advertisements viewed onEnglish-and Spanish-language television by product category and television-viewing times by age and language preference.EXPOSURE Food and beverage advertising on Spanish-and English-language television. RESULTSIn 2010, Hispanic preschoolers, children, and adolescents viewed, on average, 11.6 to 12.4 television food ads per day; the majority of these ads (75%-85%) appeared on English-language television.Fast food represented a higher proportion of food ads on Spanish-language television.Consistent with television-viewing patterns, Hispanic preschoolers saw more Spanish-language food advertisements than did Hispanic children and adolescents.Owing to somewhat less food advertising on Spanish-language television, Hispanic children and adolescents viewed 14% and 24% fewer food ads overall, respectively, compared with non-Hispanic youth.Spanish-language television viewing was highly concentrated among youth who primarily speak Spanish.CONCLUSIONS AND RELEVANCE Both Hispanic and non-Hispanic youth view large numbers of television advertisements for nutrient-poor categories of food and beverage.Although Hispanic children and adolescents see somewhat fewer of these ads, the higher obesity rates among Hispanic youth, the greater exposure by Hispanic preschoolers, and the potential enhanced effects of targeted advertising on Hispanic youth suggest that this exposure may pose additional risks for Hispanic youth.Continued monitoring is warranted owing to food companies' stated intentions to increase marketing to Hispanics.
A Four-year Prospective Trial of Unmeasured Diet In Lean Diabetic Adults
Authors: Anne M Gallagher, Carlos Abraira, William G Henderson
Journal: Diabetes Care (1984)

Fifty-one adult male outpatients at or below ideal body weight (IBW) with no history of weighing more than 15% over IBW in the past 5 yr and no more than 25% in the past 15 yr were randomly assigned to a traditional calorically defined exchange-type diet (EXCH) or an unmeasured diet emphasizing avoidance of refined sugar and balance of food consumption throughout the day. All but 4 patients were insulin treated. With the exception of one patient in each group, all patients were classified as having type II diabetes. Subjects were followed in a single-blind design for 4 yr in the Diabetes Outpatient Clinic every 3 mo. The average mean fasting glycemia (FBS), coefficient of FBS variation, number of reported hypoglycemic reactions, mean fasting serum triglyceride and cholesterol levels, and mean total daily insulin dosage were similar in both groups. Each patient's mean daily caloric intake did vary over time, but there was no difference in mean caloric intake between diet groups. There was a significant correlation between a patient's mean FBS rating and his serum triglyceride level: patients with lower mean FBS had a significantly lower mean triglyceride level than patients with higher FBS. Overall body weights remained stable throughout the study. However, there was a significant difference in the number of patients in the EXCH group whose actual weight was 3% or more above IBW on 50% or more of their visits. The unmeasured diet group had a significantly greater number of patients whose actual weight was at IBW during the study. There was no relationship between FBS and changes from IBW. In the EXCH group only subjects who increased their weight over initial levels had lower FBS values than patients who reduced from initial weight. It is concluded that individuals without history of obesity before the diagnosis of diabetes mellitus can continue to regulate their weight without a precise caloric prescription. All of the parameters studied suggest that a calorically defined exchange diet might be as effective as an unmeasured diet in the conventional long-term treatment of the lean adult diabetic patient.
Differential Expression of Mature MicroRNAs Involved in Muscle Maintenance of Hibernating Little Brown Bats, <i>Myotis Lucifugus</i>: A Model of Muscle Atrophy Resistance
Authors: Samantha F. Kornfeld, Kyle K. Biggar, Kenneth B. Storey
Journal: Genomics Proteomics & Bioinformatics (2012)

Abstract Muscle wasting is common in mammals during extended periods of immobility. However, many small hibernating mammals manage to avoid muscle atrophy despite remaining stationary for long periods during hibernation. Recent research has highlighted roles for short non-coding microRNAs (miRNAs) in the regulation of stress tolerance. We proposed that they could also play an important role in muscle maintenance during hibernation. To explore this possibility, a group of 10 miRNAs known to be normally expressed in skeletal muscle of non-hibernating mammals were analyzed by RT-PCR in hibernating little brown bats, Myotis lucifugus. We then compared the expression of these miRNAs in euthermic control bats and bats in torpor. Our results showed that compared to euthermic controls, significant, albeit modest (1.2–1.6 fold), increases in transcript expression were observed for eight mature miRNAs, including miR-1a-1, miR-29b, miR-181b, miR-15a, miR-20a, miR-206 and miR-128-1, in the pectoral muscle of torpid bats. Conversely, expression of miR-21 decreased by 80% during torpor, while expression of miR-107 remained unaffected. Interestingly, these miRNAs have been either validated or predicted to affect multiple muscle-specific factors, including myostatin, FoxO3a, HDAC4 and SMAD7, and are likely involved in the preservation of pectoral muscle mass and functionality during bat hibernation.
New Markers May Help Predict Prostate Cancer Relapse Risk
Authors: Tracy Hampton
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact of Statin Use on Oncologic Outcomes of Patients with Upper Tract Urothelial Carcinoma Treated with Radical Nephroureterectomy
Authors: Evanguelos Xylinas, Luis A. Kluth, Joseph J. Crivelli, Malte Rieken, Vitaly Margulis, Christian Seitz, Shahrokh F. Shariat
Journal: European Urology (2013)
Nora George (née Zaytoun)
Authors: Shirine Azzi
Journal: BMJ (2004)

​FormerFormer international team leader World Health Organization (b Aley, Lebanon, 1917; q Baghdad; DGO), died from heart failure on 14 January 2004.




Figure 1




After working as assistant to the chief medical officer in the children's hospital of Baghdad, Nora became doctor in charge of the mother and child centre and the maternity centre, before moving to Dublin to train in obstetrics and gynaecology. She then became international team leader for the World Health Organization in Kuwait and Libya. Nora set up many public health centres, and worked to improve basic health care for socially deprived groups. She later established her own practice in Lebanon. She leaves two children and six grandchildren.
Chronic lymphocytic leukemia cells display p53-dependent drug-induced Puma upregulation
Authors: W J M Mackus, A P Kater, A Grummels, L M Evers, B Hooijbrink, M H H Kramer, J E Castro, T J Kipps, R A W van Lier, M H J van Oers, E Eldering
Journal: Leukemia (2005)
Death of Marat I: The Victorian Agenda
Authors: John R. Sack
Journal: JAMA (1993)

To the Editor.  —You recently received two letters criticizing the JAMA cover of June 10, 1992. 1,2   Contrary to the views expressed in these letters, I wholeheartedly endorse your selection of cover material.  Since when is it the responsibility of the American Medical Association to uphold my moral well-being? I prefer to take responsibility for my own values, and hope that your other readers will do the same. I, too, am concerned about what my children experience. However, I am infinitely more disturbed by the suffocating commercialism, the disingenuous hype, and the gratuitous violence displayed in our electronic media, than I am about anything that could possibly appear on the cover of JAMA . Also, I think we send a very unhealthy message to our children when we imply that there is something dirty about the human body.  I have consistently found your covers to be edifying. They have exposed me
Demographic, clinical, and outcome features of children with acute lymphoblastic leukemia and CRLF2 deregulation: results from the MRC ALL97 clinical trial
Authors: Hannah M. Ensor, Claire Schwab, Lisa J. Russell, Sue M. Richards, Heather Morrison, Dino Masic, Lisa Jones, Sally E. Kinsey, Ajay J. Vora, Christopher D. Mitchell, Christine J. Harrison, Anthony V. Moorman
Journal: Blood (2010)
Users' Guides to the Medical Literature
Authors: Michael F. Drummond, W. Scott Richardson, Bernie J. O'Brien, Mitchell Levine, Daren Heyland
Journal: JAMA (1997)

<h3>CLINICAL SCENARIO</h3> You are a general internist on the staff of a large community hospital. Your chief of medicine knows of your interest in evidence-based medicine, and she asks you to help her solve a problem. The hospital's pharmacy and therapeutics committee has been trying to decide on formulary guidelines for the use of streptokinase or tissue-type plasminogen activator (t-PA) in the treatment of acute myocardial infarction (AMI). Members of the committee have been arguing for weeks about the Global Utlization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO) trial<sup>1</sup>and whether the added expense of t-PA is worth it. The committee has reached an impasse and has asked the chief of medicine for some outside help to reach a good decision. Knowing that the hospital faces pressure to keep costs down, the chief wants good information about this question to bring to the next committee
Silica-coated superparamagnetic iron oxide nanoparticles targeting of EPCs in ischemic brain injury
Authors: Qianyun Li, Guanghui Tang, Sihan Xue, Xiaosong He, Peng Miao, Yaning Li, Jixian Wang, Liqin Xiong, Yongting Wang, Chunfu Zhang, Guo-Yuan Yang
Journal: Biomaterials (2013)
Phosphatidylserine exposure and other apoptotic‐like events in Bernard‐Soulier syndrome platelets
Authors: Margaret L. Rand, Hong Wang, K.W. Annie Bang, Jerome M. Teitel, Victor S. Blanchette, John Freedman, Alan T. Nurden
Journal: American Journal of Hematology (2010)

In the Bernard-Soulier syndrome (BSS), the giant platelets are said to have increased phosphatidylserine (PS) surface exposure in the resting state and shortened survival in the circulation. When normal platelets are activated, they undergo many biochemical and morphological changes, some of which are apoptotic. Herein, we investigated apoptotic-like events in BSS platelets upon activation, specifically, PS exposure, microparticle (MP) formation, cell shrinkage, and loss of mitochondrial inner membrane potential (DeltaPsi(m)). Platelets from two unrelated BSS patients were examined in whole blood; agonists used were collagen, thrombin, PAR1- or PAR4-activating peptides (APs), or combinations of collagen with thrombin, and the PAR-APs. Flow cytometry was used to measure PS exposure (annexin A5 binding), platelet-derived MPs (forward scatter; events <0.75 microm size), and DeltaPsi(m) (TMRM fluorescence). PS exposure was increased on resting and activated BSS platelets, and this was independent of the platelet size. MP formation by BSS platelets was generally enhanced. Cell shrinkage occurred on activation to form smaller, PS-exposing platelets in BSS and controls. A proportion of PS-exposing BSS and control platelets exhibited DeltaPsi(m) loss, but unlike controls, there was also loss of DeltaPsi(m) in the BSS platelets not exposing PS. Thus, BSS platelets undergo apoptotic-like events upon activation, with PS exposure and MP formation being enhanced. These events may play a role in the shortened survival in BSS, as well as affecting thrombin generation.
Immune responses to nematode exoantigens: sensitizing antibodies and basophil histamine release
Authors: B. Windelborg Nielsen, P. Lind, B. Hansen, C. M. Reimert, P. Nansen, P.O. Schiøtz
Journal: Allergy (1994)

Windelborg Nielsen B, Lind P, Hansen B, Reimert CM, Nansen P, Schiotz PO. Immune responses to nematode exoantigens: sensitizing antibodies and basophil histamine release. High levels of IgE and eosinophilia are found in both allergy and helminth infections, but allergic symptoms are rare in naturally acquired helminth infections. The interrelation of specific IgE antibodies and in vitro basophil histamine release (HR) induced by exoantigens from the larval stages (L‐ 2 /L 3 ) of the nematodes Toxocara canis and Ascaris suum was examined in 148 patients visiting an outpatient clinic for parasitic diseases. The antigen sensitivity of the basophils was found to be dependent not only on the absolute amount of antigen‐specific IgE present in patient plasma, but also on the ratio between specific and total IgE. Thus, large HR was observed in some patients in response to helminth antigens despite low levels of both specific and total IgE content in plasma. Patients with eosinophilia showed greater IgE‐mediated HR than the other patients examined. In contrast, only five patients showed HR after challenge with anti‐IgG4, despite the presence of high levels of antigen‐specific IgG4 and IgGl in all patients showing specific IgE antibodies.
Apparent disapperance of hypernatraemic dehydration from infant deaths in Sheffield.
Authors: R Sunderland, J L Emery
Journal: BMJ (1979)

The death certificates and necropsy reports of the 1115 Sheffield infants who died under 2 years of age in 1969-78 were examined. This study showed the apparent disappearance of deaths with hypernatraemia and in particular deaths presenting as cot deaths. The fall in incidence may be as much the result of an intensive local campaign on child care and infant feeding as of the change in the composition of dried milk for baby feeding.
Genomic Discordance Between Monozygotic Twins Discordant for Schizophrenia
Authors: Takahiro Tsujita, Norio Niikawa, Hideji Yamashita, Akira Imamura, Akira Hamada, Yoshibumi Nakane, Yuji Okazaki
Journal: American Journal of Psychiatry (1998)

OBJECTIVE: Genomic DNA of monozygotic twins discordant for schizophrenia was analyzed to determine whether their genomes were truly identical. METHOD: The subjects were monozygotic male twins, one of whom had DSM-III-R schizophrenia, undifferentiated type. Genomic DNA was extracted from leukocytes and was applied to restriction landmark genome scanning analysis, which was developed for a high-speed survey of restriction sites throughout a genome and measurement of their copy number in each locus. RESULTS: After comparisons of patterns with approximately 2,000 spots, the authors detected at least two spots with autoradiographic intensities that obviously differed in the two twins. CONCLUSIONS: The discrepancies likely were generated either by differences in the methylation status at NotI sites between the twins or by submicroscopic changes occurring at NotI-flanking sites in one twin after (or simultaneous with) twinning. In either case, the difference may influence the transcription level of one or more genes.
Effect of Angiotensin-Converting Enzyme Inhibitors on the Progression of Nondiabetic Renal Disease
Authors: Ioannis Giatras
Journal: Annals of Internal Medicine (1997)

Background: The effect of angiotensin-converting enzyme (ACE) inhibitors in slowing the decline in renal function in nondiabetic renal disease varies among studies. Purpose: To use meta-analysis to assess the effect of ACE inhibitors on the development of end-stage renal disease caused by factors other than diabetes. Data Sources: The English-language medical literature, identified by a MEDLINE search, and unpublished studies. Study Selection: All randomized studies that compared ACE inhibitors with other antihypertensive agents and had at least 1 year of planned follow-up were selected. Studies of diabetic renal disease and renal transplants were excluded. A total of 1594 patients in 10 studies was included. Data Extraction: Data on end-stage renal disease, death, drop out, and blood pressure were extracted. Study investigators confirmed results and provided additional data. Data Synthesis: Among 806 patients receiving ACE inhibitors, 52 (6.4%) developed end-stage renal disease and 17 (2.1%) died; in the 788 controls, the respective values were 72 (9.1%) and 12 (1.5%). The pooled relative risks were 0.70 (95% CI, 0.51 to 0.97) for end-stage renal disease and 1.24 (CI, 0.55 to 2.83) for death; the studies were not significantly heterogeneous. The decreases in weighted mean systolic and diastolic blood pressures during follow-up were 4.9 and 1.2 mm Hg greater, respectively, in the patients who received ACE inhibitors. Conclusions: Angiotensin-converting enzyme inhibitors are more effective than other antihypertensive agents in reducing the development of end-stage nondiabetic renal disease, and they do not increase mortality. It could not be determined whether this beneficial effect is due to the greater decline in blood pressure or to other effects of ACE inhibition.
1048-140 Accuracy of presurgical assessment of myxomatous mitral valve pathology using real-time three-dimensional echocardiography
Authors: Lissa Sugeng, Yan Katsnelson, Lynn Weinert, R.Parker Ward, Kirk T Spencer, Jeanne M DeCara, Victor Mor-Avi, Valluvan Jeevanandam, Roberto M Lang
Journal: Journal of the American College of Cardiology (2004)