Immunoglobulin A (IgA) Immune Complex Pneumonitis in a Patient with IgA Nephropathy
Authors: Russell W. Harland, Carl G. Becker, James C. Brandes, Claire Fritsche, David Y. Rosenzweig
Journal: Annals of Internal Medicine (1992)

Brief Reports1 February 1992Immunoglobulin A (IgA) Immune Complex Pneumonitis in a Patient with IgA NephropathyRussell W. Harland, MD, Carl G. Becker, MD, James C. Brandes, MD, Claire Fritsche, MD, David Y. Rosenzweig, MDRussell W. Harland, MDSearch for more papers by this author, Carl G. Becker, MDSearch for more papers by this author, James C. Brandes, MDSearch for more papers by this author, Claire Fritsche, MDSearch for more papers by this author, David Y. Rosenzweig, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-3-220 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIdiopathic immunoglobulin A (IgA) nephropathy (Berger disease) is a syndrome characterized by mesangial proliferative glomerulonephritis with prominent mesangial deposits of IgA (1, 2). Clinical features of this syndrome include a prolonged course of persistent microscopic hematuria, intermittent macroscopic hematuria, and variable proteinuria. Typically, episodes of gross hematuria are preceded by gastroenteritis (3) or pulmonary symptoms (1, 2). Deposition of IgA in areas other than the kidney and skin has not been well described. It has been estimated that between 10% and 20% of patients progress to end-stage renal failure (1, 2).Although the pathogenesis of IgA nephropathy is unclear, most investigators...References1. Berger J. IgA glomerular deposits in renal disease. Transplant Proc. 1969;1:939-44. MedlineGoogle Scholar2. ZimmermanBurkholder SP. Immunoglobulin A nephropathy. Arch Intern Med. 1975;135:1217-23. CrossrefMedlineGoogle Scholar3. WoodroffeGormlyMcKeuzieWoottonThompsonSeymour AAPAAA. Immunologic studies in IgA nephropathy. Kidney Int. 1980;18:366-74. CrossrefMedlineGoogle Scholar4. YamabeOzawaFukushiKubotaOshawaSeino HKKHHO. Elevated serum secretory IgA in patients with IgA nephropathy. Nephron. 1989;51:499-501. CrossrefMedlineGoogle Scholar5. EndoHara YM. Glomerular IgA deposition in pulmonary diseases. Kidney Int. 1986;29:558-62. CrossrefGoogle Scholar6. YumLamptonBloomEdwards MLPJ. Asymptomatic IgA nephropathy associated with pulmonary hemosiderosis. Am J Med. 1978;64:1056-60. CrossrefMedlineGoogle Scholar7. BonninMoussonJustraboTauterChulopinRifle ACEYJG. Silicosis associated with crescentic IgA mesangial nephropathy. Nephron. 1987;47:229-30. CrossrefMedlineGoogle Scholar8. CohenRosenstein AE. IgA nephropathy associated with disseminated tuberculosis. Arch Intern Med. 1985;145:554-6. CrossrefMedlineGoogle Scholar9. KanayamaShiotaKotumiIkunoYasumotoIshiiInoue YKKYRMT. Mycoplasma pneumonia associated with IgA nephropathy. Scand J Infect Dis. 1982;14:231-3. CrossrefMedlineGoogle Scholar10. BorderBaehlerBhathenaGlassock WRDR. IgA antibasement membrane nephritis with pulmonary hemorrhage. Ann Intern Med. 1979;91:21-5. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Medical College of Wisconsin, Milwaukee, Wisconsin. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiffuse alveolar hemorrhage in IgA nephropathy: case series and systematic review of the literaturePulmonary hemorrhage with hematuria: do not forget IgA nephropathyImaging of Pulmonary VasculitisMucoviscidose et reinPulmonary Capillaritis in IgA NephropathyPulmonary Capillaritis in IgA NephropathyBronchiolitis Obliterans and IgA NephropathyIgA Nephropathy—Human Disease and Animal ModelEtiology of IgA nephropathy syndrome 1 February 1992Volume 116, Issue 3Page: 220-222KeywordsCritical careGastroenteritisGlomerulonephritisImmune complexKidneysNephrologyPathogenesisPneumonitisProteinuriaRenal failure Issue Published: 1 February 1992 PDF downloadLoading ...