tbuckley/cabot-search huggingface dataset:
BRONCHIAL ASTHMA DUE TO HACKBERRY (CELTIS) POLLEN
Authors: I. S. Kahn
Journal: JAMA (1926)

I have not been able to find in the literature any other case of asthma with this particular botanic causation. Mrs. B., aged 45, seen, March 9, 1925, for many years had had severe bronchial asthma lasting daily and almost continuously for several weeks from the middle of March to the end of April, with complete freedom from allergic symptoms at all other seasons of the year. She had lived in the same neighborhood in San Antonio for many years and had always been at home at this season. The sharply defined seasonal incidence and cessation of the asthma suggested a tree as the only known air-borne pollination possibility coinciding with the history. Intradermal tests were positive to the pollens of the grasses and ragweeds, obviously impossible factors in her case. Of the trees pollinating at this season in the locality, tests were negative to the various oak pollens, pecan,
Vivax Malaria in Veterans of the Korean War
Authors: Wendell H. Hall, George W. Loomis
Journal: New England Journal of Medicine (1952)

MALARIA due to Plasmodium vivax has virtually disappeared among veterans of World War II. In 1945 and 1946 the disease was common among patients at the Minneapolis Veterans Hospital, particularly among those who had served in the Southwest Pacific area.1 From September, 1948, to May, 1951, however, no veteran with malaria proved by blood smear was seen at this hospital. The recent return of servicemen from the conflict in Korea has resulted in the admission of 25 patients with vivax malaria between May 30 and July 21, 1951. Since little information is available concerning malaria among our troops returning from . . .
A new approach to the assessment of anaerobic metabolism: measurement of lactate in saliva.
Authors: R Segura, C Javierre, J L Ventura, M A Lizarraga, B Campos, E Garrido
Journal: British Journal of Sports Medicine (1996)

To test the hypothesis that saliva lactate concentrations may reflect those present in blood and that saliva lactate can be used as a very convenient and useful variable in the study of anaerobic metabolism.Parallel determinations were made of lactate in saliva and in capillary blood samples, obtained at 3 min intervals from nine individuals during the performance of a maximum graded exercise test on a cycle ergometer against increasing workloads (from 25 up to a maximum of 300 W). Lactate determinations were done by means of an electroenzymatic method using 25 microliters samples in both types of fluids.For each situation, the concentration of lactate in saliva was shown to be about 15% of that in plasma but it followed the same pattern of evolution during the exercise test. A good correlation (r = 0.81) between blood and saliva lactate concentrations was found. The precision of the method was very good, with a coefficient of variation ranging (n = 10) between 2.2% for samples with very low lactate concentrations and 0.7% for sample with moderate lactate concentrations. Lactate appeared to be very stable in saliva over a period of 40 days after collection, when kept at 4 degrees C. The values obtained after this period were virtually identical to those shown in fresh samples.Determination of lactate in saliva can be used as an alternative to determination in blood, overcoming most of the drawbacks of the procedures being used at present, since the collection of the samples required no special expertise.
Facilitation of Aerosol Ventilation Scanning for Diagnosis of Pulmonary Emboli in Uncooperative Dyspneic Patients
Authors: Israel Amirav, Michael T. Newhouse, Miguel Gorenberg
Journal: Clinical Nuclear Medicine (2008)

Acute pulmonary thromboembolism (PE) is a common cause of death in hospital patients. Quick and accurate diagnosis significantly decreases mortality. Many medical facilities still have ventilation/perfusion lung scans as the only available and preferred screening test for suspected PE. Although testing requires the patient's cooperation, many patients with PE are dyspneic and uncooperative. This case report illustrates a novel method of obtaining high-quality radionuclide aerosol ventilation scintigraphs in uncooperative patients by means of an easy to use hood (BabyAir; BabyBreath, Or Akiva, Israel). There is no need for patients to neither undertake difficult breathing maneuvers nor to use a mouth-piece or mask.
A Toxicologic Review of Quantum Dots: Toxicity Depends on Physicochemical and Environmental Factors
Authors: Ron Hardman
Journal: Environmental Health Perspectives (2005)

As a growing applied science, nanotechnology has considerable global socioeconomic value, and the benefits afforded by nanoscale materials and processes are expected to have significant impacts on almost all industries and all areas of society. A diverse array of engineered nanoscale products and processes have emerged [e.g., carbon nanotubes, fullerene derivatives, and quantum dots (QDs)], with widespread applications in fields such as medicine, plastics, energy, electronics, and aerospace. With the nanotechnology economy estimated to be valued at dollar 1 trillion by 2012, the prevalence of these materials in society will be increasing, as will the likelihood of exposures. Importantly, the vastness and novelty of the nanotechnology frontier leave many areas unexplored, or underexplored, such as the potential adverse human health effects resulting from exposure to novel nanomaterials. It is within this context that the need for understanding the potentially harmful side effects of these materials becomes clear. The reviewed literature suggests several key points: Not all QDs are alike; engineered QDs cannot be considered a uniform group of substances. QD absorption, distribution, metabolism, excretion, and toxicity depend on multiple factors derived from both inherent physicochemical properties and environmental conditions; QD size, charge, concentration, outer coating bioactivity (capping material and functional groups), and oxidative, photolytic, and mechanical stability have each been implicated as determining factors in QD toxicity. Although they offer potentially invaluable societal benefits such as drug targeting and in vivo biomedical imaging, QDs may also pose risks to human health and the environment under certain conditions. Key words: environment, human health, nanomaterials, nanosized particles, nanotechnology, nanotoxicology, quantum dots, toxicology.
Expunging Variola: The Control and Eradication of Smallpox in India 1947-1977
Authors: Donald R. Hopkins
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Learning from low income countries: what are the lessons?: Improvement can occur even in resource constrained settings
Authors: Rocío Sapag, Jaime Bayona
Journal: BMJ (2004)

EDITOR—Berwick's editorial on the lessons from developing nations on improving health care mistakenly abstracts improvement efforts from the complex context of poverty and inequality.1 Improvement is “an inborn human endeavour,” yet an under-nourished or sick child who wants to “jump higher or run faster” cannot do so unless basic needs are met first.1 In Peru we learnt that notable improvement …
VERY LATE STENT THROMBOSIS AFTER REVASCULARIZATION WITH EVEROLIMUS- AND SIROLIMUS-ELUTING STENTS FROM THE SORT OUT IV TRIAL
Authors: Lisette Okkels Jensen, Per Thayssen, Evald Christiansen, Michael Maeng, Jan Ravkilde, Knud Hansen, Henrik Hansen, Lars Krusell, Klára Berencsi, Anne Kaltoft, Hans-Henrik Tilsted, Anders Junker, Jens Lassen
Journal: Journal of the American College of Cardiology (2014)
THE ROMANCE OF MEDICINE
Authors: WILLIAM D. HAGGARD
Journal: JAMA (1925)

"Taught by art divine the sage physician eludes the urn, and chains or exiles death." The story of medicine enthralls the imagination by its infinite charm and arouses admiration for its victories in the battles against disease. Its romance is so compelling that men cannot be unmoved by its blessings, when they realize with us its splendor. The records of the discoveries of medicine are more fascinating than fiction; their marvelous benefits are as if in response to Jeremiah's lament, "Is there no balm in Gilead, is there no physician there?" The price of these great benefactions is beyond all the rubies of the world; it can never be computed and it can never be paid. In the Middle Ages the average life of man was twenty-odd years. Now the span has been increased almost threefold. Compute if you can the growth in economic value of a human life extended
Tracheal Uptake on Tc-99m MDP Bone Scintigraphy Can Be a Potential Source of False-Positive Results in a Prostate Cancer Patient
Authors: Ashwani Sood, Sandeep Sethi, Rakesh Kumar
Journal: Clinical Nuclear Medicine (2010)

Tc-99m methylene diphosphonate (MDP) bone scintigraphy has been long used to diagnose osseous metastases in patients with cancer. However, the nonosseous entities adjacent to bony structures delineated on a routine bone scan may mimic as skeletal metastatic lesions. The authors describe the case of an 83-year-old man with prostate cancer, showing tracer uptake in the cervical region on bone scan that required additional views/imaging to demonstrate the uptake to be extraskeletal. The present case highlights that bone scintigraphy may have an unusual uptake of radiotracer in other organs\regions apart from the skeletal system due to pathophysiological changes that warrant careful interpretation.
Institutional Review Boards Under Stress: Will They Explode or Change?
Authors: Donald F. Phillips
Journal: JAMA (1996)

INSTITUTIONAL REVIEW boards (IRBs), created some 20 years ago by the US government as a mechanism for the protection of human research subjects, now find themselves under pressure from mounds of paperwork, regulatory fire from the federal bureaucracy, and economic constraints from the institutions they serve. Never before has such a pressure-cooker atmosphere prevailed within the IRB system, leading government officials, university administrators, research sponsors, and IRB members to wonder whether the IRB system will crack or reform. <h3>Background of the Problem</h3> The National Research Act of 1974, which created the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research, also mandated the establishment of IRBs in all research organizations receiving funds to support research using human subjects. The legislation also directed the national commission to identify ethical principles relevant to human subjects research, develop guidelines for the conduct of such research, and examine IRB mechanisms
Minocycline-associated lupus erythematosus
Authors: P.M GORDON, M.I WHITE, R. HERRIOT, J.C MARTIN, D.M REID
Journal: British Journal of Dermatology (1995)

We report a patient who developed symptoms of lupus erythematosus which was apparently related to minocycline therapy for acne vulgaris. To our knowledge, this is only the second reported case of minocycline‐associated lupus erythematosus.
CTLA-4 polymorphisms and clinical outcome after allogeneic stem cell transplantation from HLA-identical sibling donors.
Authors: Arianne Pérez-García, Rafael De la Cámara, Jose Román-Gómez, Antonio Jiménez-Velasco, Maite Encuentra, Jose B. Nieto, Javier de la Rubia, Alvaro Urbano-Ispizúa, Salut Brunet, Arturo Iriondo, Marcos González, David Serrano, Ildefonso Espigado, Carlos Solano, Josep M. Ribera, Josep M. Pujal, Montserrat Hoyos, David Gallardo
Journal: Blood (2007)
PERNICIOUS ANAEMIA AND THE LIVER DIET
Authors: C. F. T. East
Journal: BMJ (1928)

PERNICIOUS ANAEMIA AND -TRE LIVER DIET.r THEIBMIICSA 491 ureter;al clculuns a few hours before the time fixed for his oleration.In aiiother case the renal stone w-as removed fr,omn the pelvis aind olive oil injected dowin the ureter by a glass syringe, the nozzle of whiclh was passed througlh the pJyelotoniy inicision anid fitted snugly into the upper part of the ureter.The ureter became distended anid this sub- sided suddenly.The cystoscope was passed at the end of tlle oper1ation and a small calculus was seen in the bladder linig in a pool of oil.This was passed a few days later.I have oedeavoured to give, as accurately as possible, the late results of these operations for renal calculus.It is very difficult indeed to obtain absolute accuracy of state- teat on such a subject unless one has the advantage of a large staff to carry out the necessary inquiries and to make the nece'ssary investigations.There is, however, sufficient evidenice to slhow that the frequenicy of recurrence after operations for renal calculus is such that it demands very ser-ious inivestigation.
A CASE OF ABDOMINAL ANEURISM: WITH REMARKS UPON ITS DIFFERENTIAL DIAGNOSIS
Authors: C. M. Durrant
Journal: BMJ (1854)

re M it e of a Icom$sh ie t th oda surgeon of ordinary dexterity.The pathological views above adduced will further tend to imprss upon the practitioner's mind the expdiency of adopting this measure el in the disease, givig addi- tiosal fouce to the obsrvation of Louis, that, "alons g as bronehotomy is considered an extreme measure (an demur ierS), it will be always performed too late."The period of the attack at which the indication for its employment will aise must vary in the different forms, as well as in in- dividual instances of the same form, of the malady.I have met with cases in which an attack of croup, preceding and retarding the eruptive stage of some of the exanthemat continued for four, five, or even six days, without percep tible abatement of the laryngeal symptoms, but in which notwithstanding, there was no necessity for surgical inter- fernce; and I have also seen examples of the same sub- acute and unyielding condition, similar or even greater in duration in the diphtheritic variety of this affection, where operative procedure was equally uncalled for.On the other hand, circumstances will present themselves, and an
STUDIES ON THE CHEMOTHERAPY OF THE HUMAN MALARIAS. V. THE ANTIMALARIAL ACTIVITY OF QUINACRINE 123
Authors: John V. Taggart, David P. Earle, Robert W. Berliner, William J. Welch, Charles G. Zubrod, Joseph W. Jailer, Beatrice H. Kuhn, Jackson Norwood, James A. Shannon
Journal: Journal of Clinical Investigation (1948)
Controversial Practices in Allergy-Reply
Authors: Michael H. Grieco
Journal: JAMA (1982)

<h3>In Reply.—</h3> I am pleased that Dr Miller has chosen to comment on the intradermal provocative-neutralization method. The text of my review of "Controversial Practices in Allergy" clearly indicated that the method outlined by Rinkel et al<sup>1</sup>in 1964 was summarized in Table 5. It is unlikely that this method was abandoned before publication. My article inThe Journaldid not state that Miller's positive double-blind study results were followed by four controlled studies unable to support the efficacy of this method. The text stated "However, four controlled studies were unable to support the efficacy of this method." There is no indication of the priority of publication. Dr Miller's suggestion that his study of the therapy for eight patients published in 1977<sup>2</sup>that used his version of the technique is adequate support for this procedure is unacceptable. Multiple and reproducible studies designed to eliminate bias must remain the
Management of acute myocardial infarction.
Authors: K Lee
Journal: BMJ (1976)

undergo a particular line of treatment which is also dangerous.We wish the treatment to be as safe as it can be made, but it is still up to the patient or his relatives to decide whether to accept it or not.If things go wrong, and especially if one had more or less forced a decision, it is the surgeon who gets the blame, not the patient.
Need for Clinical Pharmacologists
Authors: Peter J. Forni
Journal: JAMA (1973)

<h3>To the Editor.—</h3> We read with interest the EDITORIAL by Dykes inThe Journal(223:1497, 1973) and concur with him regarding the need for more clinical pharmacologists. Although Dr. Dykes' proposal to increase the number of clinical pharmacologists to fulfill the need would be the ideal approach, it is probably not the most practical nor the most feasible one. Dr. W.W. Oppelt is another practitioner who has been aware of "difficulty in recruiting trainees into the field"<sup>1</sup>as a major problem facing clinical pharmacology today. Perhaps the role of a consultant, although beneficial to the patient and the patient's physician, may not be sufficiently gratifying to the majority of physicians who want to specialize and be responsible for the final decision regarding the care and treatment of their patients. Furthermore, the prohibitive cost of training a sufficient number of graduate physicians to supply the demand necessitates consideration of an
An EBF3-Mediated Transcriptional Program That Induces Cell Cycle Arrest and Apoptosis
Authors: Lisa Y. Zhao, Yuxin Niu, Aleixo Santiago, Jilin Liu, Sara H. Albert, Keith D. Robertson, Daiqing Liao
Journal: Cancer Research (2006)

Abstract In a genome-wide screen for putative tumor suppressor genes, the EBF3 locus on the human chromosome 10q26.3 was found to be deleted or methylated in 73% of the examined cases of brain tumors. EBF3 is expressed in normal brain but is silenced in brain tumors. Therefore, it is suggested that EBF3 is a tumor suppressor. However, it remains unknown whether inactivation of EBF3 locus also occurs in other types of tumors and what functions of EBF3 underlie EBF3-mediated tumor suppression. We show here that expression of EBF3 resulted in cell cycle arrest and apoptosis. The expression of cyclin-dependent kinase inhibitors was profoundly affected with early activation and then repression of p21cip1/waf1 and persistent activation of both p27kip1 and p57kip2, whereas genes involved in cell survival and proliferation were suppressed. EBF3 bound directly to p21cip1/waf1 promoter and regulated transcription from both p21cip1/waf1 and p27kip1 promoters in reporter assays. Apoptosis occurred 48 hours after EBF3 expression with caspase-3 activation. Silencing of the EBF3 locus was observed in brain, colorectal, breast, liver, and bone tumor cell lines and its reactivation was achieved on treatment with 5-aza-2′-deoxycytidine and trichostatin A in a significant portion of these tumor cells. Therefore, EBF3 regulates a transcriptional program underlying a putative tumor suppression pathway. (Cancer Res 2006; 66(19): 9445-52)
Gastroenterology and Hepatology
Authors: Raymond S. Koff
Journal: JAMA (1995)

Development of colon cancer is now believed to result from a series of inherited or acquired mutations in DNA. Convincing evidence that colonoscopic polypectomy prevents colorectal cancer is now available. A consensus panel recommended that all patients with duodenal and gastric ulcers who are infected with H pylori on first presentation be treated with antimicrobial agents.
Abstract 3939: The collagen receptor discoidin domain receptor 2 facilitates breast cancer metastasis by stabilizing Snail1 protein.
Authors: Kun Zhang, Callie Corsa, Julie Prior, David Piwnica-Worms, Gregory D. Longmore
Journal: Cancer Research (2013)

Abstract Mammographic density is a leading risk factor for the development of breast cancer and these cancers are more invasive and metastatic. The increase in breast density is, in part, due to increased fibrillar collagen deposition. In an RNAi human kinome screen to identify post-transcriptional regulators of Snail1 protein stability we found the collagen receptor DDR2, but not related DDR1, to stabilize Snail1 protein as a result of collagen I activated DDR2 stimulation of ERK2 activity. This can occur independent of β1-integrin and TGFβ signals. DDR2 is not required for TGFβ-induced Epithelial Mesenchymal transition (EMT) or EMT-induced Snail1 transcription. Rather DDR2 expression, which is absent in normal breast epithelia, is induced during EMT as breast tumor cells assume invasive, mesenchymal features. DDR2-induced ERK2 activity stabilizes Snail1 protein level in two ways. First, ERK2 interacts with and phosphorylates Snail1 and second ERK2 inhibits GSK3b. DDR2 was found to be critical for breast cancer cell invasion and migration in vitro, in 3D collagen gels, and breast cancer metastasis in vivo, in syngeneic xenograft models. A majority of human invasive ductal breast carcinomas express DDR2 protein and there is a strong association between nuclear Snail1 expression, DDR2 expression, and the absence of E-cadherin expression. The small group of breast cancer patients with tumors harboring increased DDR2 gene copy number has diminished survival. We propose that DDR2 acts in a positive feedback loop to maintain Snail1 protein level and activity in breast tumor cells at the leading, invasive edge where tumor cells that have undergone EMT and invaded through the basement membrane to encounter extracellular matrix collagen I. This facilitates the continued tumor cell invasion and migration through the collagen I-rich ECM, and thereby, contributes to breast cancer metastasis. That the collagen I receptor DDR2 maintains the EMT-inducing Snail1 protein level and activity and contributes to breast cancer metastasis could explain the increase in metastasis of breast cancers in women with dense breasts. As such, DDR2 could be considered a novel RTK target for the treatment of breast cancer metastasis. Citation Format: Kun Zhang, Callie Corsa, Julie Prior, David Piwnica-Worms, Gregory D. Longmore. The collagen receptor discoidin domain receptor 2 facilitates breast cancer metastasis by stabilizing Snail1 protein. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3939. doi:10.1158/1538-7445.AM2013-3939
Incidence of Glaucomatous Visual Field Loss: A Ten-Year Follow-up from the Rotterdam Study
Authors: Monika A. Czudowska, Wishal D. Ramdas, Roger C.W. Wolfs, Albert Hofman, Paulus T.V.M. De Jong, Johannes R. Vingerling, Nomdo M. Jansonius
Journal: Ophthalmology (2010)