Update in Pulmonary and Critical Care Medicine: Evidence Published in 2010
Authors: Rose G. Heuser, Molly L. Osborne, Jesse Hall
Journal: Annals of Internal Medicine (2011)

Updates3 May 2011Update in Pulmonary and Critical Care Medicine: Evidence Published in 2010Rose G. Heuser, MD, Molly L. Osborne, MD, PhD, and Jesse Hall, MDRose G. Heuser, MDFrom Oregon Health & Science University, Portland, Oregon, and University of Chicago, Chicago, Illinois.Search for more papers by this author, Molly L. Osborne, MD, PhDFrom Oregon Health & Science University, Portland, Oregon, and University of Chicago, Chicago, Illinois.Search for more papers by this author, and Jesse Hall, MDFrom Oregon Health & Science University, Portland, Oregon, and University of Chicago, Chicago, Illinois.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-9-201105030-00339 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In pulmonary medicine, important contributions have built on a growing body of literature about the best management of chronic airflow obstruction. A double-blind, 3-way crossover trial demonstrated that for patients with uncontrolled asthma who receive inhaled corticosteroids, adding tiotropium was similar to adding salmeterol and superior to doubling the dosage of inhaled corticosteroids. A large observational study of chronic obstructive pulmonary disease (COPD) demonstrated that patients who self-reported frequent exacerbations would probably continue to have exacerbations regardless of COPD severity. Although idiopathic pulmonary fibrosis (IPF) continues to have only a 3- to 5-year survival rate, a double-blind, randomized, multicenter trial ...References1. Singh S, Loke YK, Furberg CD. Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA. 2008;300:1439-50. [PMID: 18812535] CrossrefMedlineGoogle Scholar2. Tashkin DP, Celli B, Senn S, Burkhart D, Kesten S, Menjoge S, et al; UPLIFT Study Investigators. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med. 2008;359:1543-54. [PMID: 18836213] CrossrefMedlineGoogle Scholar3. Seemungal TA, Donaldson GC, Paul EA, Bestall JC, Jeffries DJ, Wedzicha JA. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157:1418-22. [PMID: 9603117] CrossrefMedlineGoogle Scholar4. Au DH, Bryson CL, Chien JW, Sun H, Udris EM, Evans LE, et al. The effects of smoking cessation on the risk of chronic obstructive pulmonary disease exacerbations. J Gen Intern Med. 2009;24:457-63. [PMID: 19194768] CrossrefMedlineGoogle Scholar5. Collard HR, Anstrom KJ, Schwarz MI, Zisman DA. Sildenafil improves walk distance in idiopathic pulmonary fibrosis. Chest. 2007;131:897-9. [PMID: 17356110] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Oregon Health & Science University, Portland, Oregon, and University of Chicago, Chicago, Illinois.Article relevant to primary care general internistsArticle relevant to hospitalistsDisclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M11-0257.Corresponding Author: Molly Osborne, MD, PhD, Pulmonary and Critical Care, Department of Medicine, Oregon Health & Science University, Portland, OR 97239.Current Author Addresses: Drs. Heuser and Osborne: Department of Medicine, Oregon Health & Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239-3098.Dr. Hall: Section of Pulmonary and Critical Care Medicine, University of Chicago Hospitals and Clinics, MC 6026, 5847 South Maryland Avenue, Chicago, IL 60637.Author Contributions: Conception and design: M. Osborne, J. Hall.Analysis and interpretation of the data: J. Hall.Drafting of the article: R.G. Heuser, M. Osborne, J. Hall.Critical revision of the article for important intellectual content: M. Osborne, J. Hall.Final approval of the article: M. Osborne, J. Hall.Administrative, technical, or logistic support: M. Osborne, J. Hall.Collection and assembly of data: M. Osborne, J. Hall. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTools to optimize the functionality of a leukemia clinical trial team 3 May 2011Volume 154, Issue 9Page: 614-621KeywordsAsthmaIntensive care unitsInterstitial lung diseasesLungsPalliative careQuality of lifeVentilators ePublished: 3 May 2011 Issue Published: 3 May 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...