Nonbeta Islet-cell Carcinoma of the Pancreas Presenting as Diarrhea
Authors: WILLIAM H. SHAFER
Journal: Annals of Internal Medicine (1964)

Case Studies1 September 1964Nonbeta Islet-cell Carcinoma of the Pancreas Presenting as DiarrheaReport of a CaseWILLIAM H. SHAFER, M.D.WILLIAM H. SHAFER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-3-539 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe association of severe peptic ulcer disease with a noninsulin-producing islet-cell carcinoma of the pancreas was described by Zollinger and Ellison (1) in 1955, and by 1960 more than 80 cases of this syndrome had been reported (2). It is now recognized that in this syndrome the initial symptom may be severe diarrhea, preceding peptic ulcer formation by many months or years (2-8). The case reported here is an example of a nonbeta islet-cell carcinoma initially presenting as a severe diarrhea.REPORT OF A CASEA 16-year-old Negro boy was first examined at the Cleveland Clinic Hospital in January, 1961....References1. ZOLLINGERELLISON RMEH: Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Ann. Surg. 142: 709, 1955. CrossrefMedlineGoogle Scholar2. ZOLLINGERCRAIG RMTV: Endocrine tumors and peptic ulcers. Amer. J. Med. 29: 761, 1960. CrossrefMedlineGoogle Scholar3. VERNERMORRISON JVAB: Islet cell tumor and a syndrome of refractory watery diarrhea and hypokalemia. Amer. J. Med. 25: 374, 1958. CrossrefMedlineGoogle Scholar4. RAWSONENGLANDGILLAMFRENCHSTAMMERS ABMTGGJMFA: Zollinger-Ellison syndrome with diarrhoea and mal-absorption. Observations on a patient before and after pancreatic islet-cell tumour removal with-out resort to gastric surgery. Lancet 2: 131, 1960. CrossrefMedlineGoogle Scholar5. CHEARSTHOMPSONHUTCHESONPATTERSON WCJEJBCO: Pancreatic islet tumor with severe diarrhea. Amer. J. Med. 29: 529, 1960. CrossrefMedlineGoogle Scholar6. MAYNARDPOINT EPWW: Steatorrhea associated with ulcerogenic tumor of the pancreas. Amer. J. Med. 25: 456, 1958. CrossrefMedlineGoogle Scholar7. SUMMERSKILL WH: Malabsorption and jejunal ulceration due to gastric hypersecretion with pancreatic islet-cell hyperplasia. Lancet 1: 120, 1959. CrossrefMedlineGoogle Scholar8. TELLINGSMIDDY MFG: Islet tumors of the pancreas with intractable diarrhoea. Gut 2: 12, 1961. CrossrefMedlineGoogle Scholar9. GREGORYTRACYFRENCHSIRCUS RAHJJMW: Extraction of a gastrin-like substance from a pancreatic tumour in a case of Zollinger-Ellison syndrome. Lancet 1: 1045, 1960. CrossrefMedlineGoogle Scholar10. HAUBRICHO'NEILBLOCK WSFSMA: Observations on steatorrhea associated with gastric hypersecretion and pancreatic islet cell neoplasm (abstract). Ann. Intern. Med. 54: 1048, 1961. LinkGoogle Scholar11. GROSSMANTRACYGREGORY MIHJRA: Zollinger-Ellison syndrome in a Bantu woman, with isolation of a gastrin-like substance from the primary and secondary tumors. II. Extraction of a gastrin-like activity from tumors. Gastroenterology 41: 87, 1961. CrossrefMedlineGoogle Scholar12. MARKSSELZERLOUWBANK INGJHS: Zollinger-Ellison syndrome in a Bantu woman, with isolation of a gastrin-like substance from the primary and secondary tumors. I. Case report. Ibid., p. 77. Google Scholar13. MONACOLYTHGOEWADDELL APJPWR: Immunological study in the Zollinger-Ellison syndrome. Lancet 2: 1016, 1961. CrossrefMedlineGoogle Scholar14. CODEHALLENBECKSUMMERSKILL CFGAWH: Extraction of a gastric secretagogue from primary and metastatic islet cell tumors in three cases of Zollinger-Ellison syndrome. J. Surg. Res. 2: 136, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM H. SHAFER, M.D.Affiliations: Cleveland, OhioFrom the Department of Internal Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio.Requests for reprints should be addressed to William H. Shafer, M.D., Department of Internal Medicine, The Cleveland Clinic Foundation, 2020 East 93rd Street, Cleveland 6, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySynthetic human gastrin I and gastrin-like pentapeptide in studies of intestinal absorption in manDas Verner-Morrison-SyndromOccult Adenocarcinoma of the Pancreas in A 17-Year-Old Patient with Immunosuppressed LeukemiaZollinger-Ellison SyndromeRadiologic evaluation of pancreatic diseases in childrenThe PancreasWatery Diarrhea and Hypokalemia Associated with Pancreatic Islet Cell AdenomaDiarrhea and Pancreatic Islet Cell Tumor 1 September 1964Volume 61, Issue 3Page: 539-543KeywordsDiarrheaHospitalsPancreasPeptic ulcers ePublished: 1 December 2008 Issue Published: 1 September 1964 PDF downloadLoading ...