Hypogammaglobulinemia with Thymoma, Hemolytic Anemia, and Disseminated Infection with Cytomegalovirus
Authors: EDWARD S. MONGAN
Journal: Annals of Internal Medicine (1966)

Case Studies1 September 1966Hypogammaglobulinemia with Thymoma, Hemolytic Anemia, and Disseminated Infection with CytomegalovirusEDWARD S. MONGAN, M.D., F.A.C.P., WILLIAM A. KERN JR., M.D., ROGER TERRY, M.D.EDWARD S. MONGAN, M.D., F.A.C.P.Search for more papers by this author, WILLIAM A. KERN JR., M.D.Search for more papers by this author, ROGER TERRY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-3-548 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years it has been established that the intact thymus is a significant contributor to the immunological integrity of a number of neonatal animals. The function of the thymus in adults is unclear, but reports of patients with coexisting thymic tumors and hypogammaglobulinemia suggest that the thymus may contribute to immunologic processes in adult life. A male patient with hypogammaglobulinemia, a thymoma, and probable pulmonary infection with cytomegalovirus has previously been reported by us (1). This report concerns a second case in a female patient with a thymoma removed in 1956. Subsequently she developed multiple bacterial infections, and in...References1. JACOXMONGANHANSHAWLEDDY RFESJBJP: Hypogammaglobulinemia with thymoma and probable pulmonary infection with cytomegalovirus. New Eng. J. Med. 271: 1091, 1964. CrossrefMedlineGoogle Scholar2. BARNETTCONDEMILEDDYVAUGHAN EVJJJPJH: Gamma 2, gamma 1A and gamma IM antinuclear factors in human sera. J. Clin. Invest. 43: 1104, 1964. CrossrefMedlineGoogle Scholar3. BECKERMUNOZLAPRESLELEBEAU ELJCLJ: Antigen-antibody reactions in agar. II. Elementary theory and determination of diffusion coefficients of antigen. J. Immun. 67: 501, 1951. MedlineGoogle Scholar4. RUBINSTEIN HM: Quantitative antigen analysis by the Oudin method. J. Immun. 73: 322, 1954. MedlineGoogle Scholar5. 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Report of three cases and a review of the syndrome. Brit. J. Haemat. 6: 178, 1960. CrossrefMedlineGoogle Scholar18. ROSSFINCHSTREETSTRIEDER JFSCRBJW: The simultaneous occurrence of benign thymoma and refractory anemia. Blood 9: 935, 1954. CrossrefMedlineGoogle Scholar19. BECKEREDDY FPJR: Autoimmune hemolytic anemia with terminal lymphoma and cytomegalic inclusion disease. New York J. Med. 64: 1211, 1964. MedlineGoogle Scholar20. ZUELZERSTULBERGPAGETERUYABROUGH WWCSRHJAJ: The etiology of acquired hemolytic anemia. The Society for Pediatric Research Program and Abstracts, 1965, p. 29. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New YorkFrom the Departments of Medicine and Pathology, The University of Rochester School of Medicine and Dentistry, Rochester, N. Y.This study was supported by grant CRMC 25 from the Arthritis Foundation, New York, N. Y.This study was presented in part at the XI International Congress of Rheumatology, Mar del Plata, Argentina, in December, 1965.Requests for reprints should be addressed to Edward S. Mongan, M.D., Department of Medicine, Strong Memorial Hospital, 260 Crittenden Blvd., Rochester, N. Y. 14620. 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