High-Dosage Vitamin E Supplementation and All-Cause Mortality
Authors: Kent J. DeZee, William Shimeall, Kevin Douglas, Jeffrey L. Jackson
Journal: Annals of Internal Medicine (2005)

Letters19 July 2005High-Dosage Vitamin E Supplementation and All-Cause MortalityKent J. DeZee, MD, MPH, William Shimeall, MD, MPH, Kevin Douglas, MD, and Jeffrey L. Jackson, MD, MPHKent J. DeZee, MD, MPHFrom Walter Reed Army Medical Center, Washington, DC 20307., William Shimeall, MD, MPHFrom Walter Reed Army Medical Center, Washington, DC 20307., Kevin Douglas, MDFrom Walter Reed Army Medical Center, Washington, DC 20307., and Jeffrey L. Jackson, MD, MPHFrom Walter Reed Army Medical Center, Washington, DC 20307.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-2-200507190-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Although we read Miller and colleagues' article (1) with interest, we question their conclusions regarding high-dose vitamin E. First, it is not clear why the authors chose hierarchical logistic regression rather than traditional meta-analytic approaches. We reanalyzed their data from the 11 high-dose trials in their Figure 2 using 2 standard methods (Wolfe inverse variance and Mantel–Haenszel). Both yielded the same point estimates as the ones the authors reported, but with nonsignificant results (relative risk, 1.04 [95% CI, 0.99 to 1.10]). Second, we are concerned that these results are heterogeneous. Both are borderline statistically heterogeneous (Q = 16.1; ...References1. Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142:37-46. [PMID: 15537682] LinkGoogle Scholar2. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088-101. [PMID: 7786990] CrossrefMedlineGoogle Scholar3. Duval S, Tweedie R. Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000;56:455-63. [PMID: 10877304] CrossrefMedlineGoogle Scholar4. Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA. 1995;273:408-12. [PMID: 7823387] CrossrefMedlineGoogle Scholar5. Moher D, Cook DJ, Eastwood S, Olkin I, Rennie D, Stroup DF. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of Reporting of Meta-analyses. Lancet. 1999;354:1896-900. [PMID: 10584742] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Walter Reed Army Medical Center, Washington, DC 20307.Disclaimer: The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality Edgar R. Miller III , Roberto Pastor-Barriuso , Darshan Dalal , Rudolph A. Riemersma , Lawrence J. Appel , and Eliseo Guallar High-Dosage Vitamin E Supplementation and All-Cause Mortality Antonio M. Possolo High-Dosage Vitamin E Supplementation and All-Cause Mortality Ishwarlal Jialal and Sridevi Devaraj High-Dosage Vitamin E Supplementation and All-Cause Mortality Thomas Carter High-Dosage Vitamin E Supplementation and All-Cause Mortality Joseph E. Baggott High-Dosage Vitamin E Supplementation and All-Cause Mortality Edgar R. Miller III , Lawrence J. Appel , Eliseo Guallar , and Roberto Pastor-Barriuso Brief Communication: The Prevalence of High Intake of Vitamin E from the Use of Supplements among U.S. Adults Earl S. Ford , Umed A. Ajani , and Ali H. Mokdad An Editorial Update: Annus horribilis for Vitamin E Eliseo Guallar , Daniel F. Hanley , and Edgar R. Miller III High-Dosage Vitamin E Supplementation and All-Cause Mortality David H. Blatt and William A. Pryor High-Dosage Vitamin E Supplementation and All-Cause Mortality Koyamangalath Krishnan , Sharon Campbell , and William L. Stone High-Dosage Vitamin E Supplementation and All-Cause Mortality Harri Hemilä High-Dosage Vitamin E Supplementation and All-Cause Mortality Wee-Shiong Lim , Rajka Liscic , Chengjie Xiong , and John C. Morris High-Dosage Vitamin E Supplementation and All-Cause Mortality Connie Marras , Anthony E. Lang , David Oakes , Michael P. McDermott , Karl Kieburtz , Ira Shoulson , Caroline M. Tanner , and Stanley Fahn High-Dosage Vitamin E Supplementation and All-Cause Mortality Simin Nikbin Meydani , Joseph Lau , Gerard E. Dallal , and Mohsen Meydani Metrics Cited byAntioxidants in Food: Mere Myth or Magic Medicine?Nutrient plasma levels achieved during treatment that reduces noise-induced hearing lossBioactive Nutritional Supplements for Chronic Kidney Disease: Potential Cost BenefitsDecision Analysis Supports the Paradigm That Indiscriminate Supplementation of Vitamin E Does More Harm than GoodAdverse effects of vitamin E by induction of drug metabolismCellular, molecular and clinical aspects of vitamin E on atherosclerosis preventionVitamin E Regulatory MechanismsThe Roles of α‐Vitamin E and Its Analogues in Prostate Cancer 19 July 2005Volume 143, Issue 2Page: 153-154KeywordsConfidence intervalsConflicts of interestHeartLongitudinal studiesQuality improvementRisk managementStatistical methodsVitamin E ePublished: 19 July 2005 Issue Published: 19 July 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...