Uveitis Associated with Rifabutin Prophylaxis and Itraconazole Therapy
Authors: Agnes Lefort
Journal: Annals of Internal Medicine (1996)

Letters1 December 1996Uveitis Associated with Rifabutin Prophylaxis and Itraconazole TherapyAgnes Lefort, MD, Odile Launay, MD, and Claude Carbon, MDAgnes Lefort, MDHopital Bichat-Claude Bernard, Paris, France., Odile Launay, MDHopital Bichat-Claude Bernard, Paris, France., and Claude Carbon, MDHopital Bichat-Claude Bernard, Paris, France.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-11-199612010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Although anterior uveitis is a frequent complication of rifabutin therapy [1], it occurs infrequently with rifabutin prophylaxis (300 mg/d) [2]. This condition, however, has been seen during concomitant administration of rifabutin and either fluconazole or clarithromycin; this suggests that a drug interaction may be responsible for this complication [3]. We describe a patient with human immunodeficiency virus infection who developed anterior uveitis while receiving rifabutin prophylaxis during itraconazole therapy.A 49-year-old man with a history of Pneumocystis carinii pneumonia and bilateral cytomegalovirus retinitis was hospitalized with anterior uveitis of the left eye. He had been receiving rifabutin ...References1. Shafran SD, Deschenes J, Miller M, Philllps P. Toma E. Uveitis and pseudojaundice during a regimen of clarithromycin, rifabutin, and ethambutol [Letter]. MAC Study Group of the Canadian HIV Trials Network. N Engl J Med. 1994; 330:438-9. Google Scholar2. Nightingale SD, Cameron DW, Gordin FM, Sullam PM, Cohn DL, Chaisson RE, et al. Two controlled trials of rifabutin prophylaxis against Mycobacterium avium complex infection in AIDS. N Engl J Med. 1993; 329:828-33. Google Scholar3. Trapnell CB, Narang PK, LR, Lavelle JP. Increased plasma rifabutin levels with concomitant fluconazole therapy in HIV-infected patients. Ann Intern Med. 1996; 124:573-6. Google Scholar Author, Article, and Disclosure InformationAffiliations: Hopital Bichat-Claude Bernard, Paris, France. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrug-induced UveitisRifamycin Antibacterial AgentsConcomitant Use of Voriconazole and Rifabutin in a Patient with Multiple InfectionsCost-Effectiveness Analysis of Telemedicine to Evaluate Diabetic Retinopathy in a Prison PopulationDrug interactions common in patients with HIV infection and Mycobacterium avium complex diseaseAIDS/HIV: Drugs for Opportunistic InfectionsDrug-Drug Interactions of Clinical Significance in the Treatment of Patients with Mycobacterium avium Complex DiseaseEffects of the Antifungal Agents on Oxidative Drug MetabolismItraconazoleDrug interactions with itraconazole, fluconazole, and terbinafine and their managementDrug interactions and anti-infective therapiesMETABOLISM-BASED DRUG INTERACTIONS INVOLVING ORAL AZOLE ANTIFUNGALS IN HUMANS*Antifungal Agents. Part II. The AzolesUpdate on Drug Interactions with Azole Antifungal AgentsAntifungal drugsRifabutin interaction 1 December 1996Volume 125, Issue 11Page: 939-940KeywordsDrug metabolismDrugsMetabolitesOral administrationPneumoniaProphylaxisRetinitisRisk managementSteroidsUveitis Issue Published: 1 December 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...