tbuckley/cabot-search huggingface dataset:
Long-Term Survival of Breast Ductal Carcinoma In Situ in Women with Different Gene-Expression Types.
Authors: W. Zhou, C. Johansson, K. Jirström, A. Olorunsola, H. Garmo, F. Wärnberg
Journal: Cancer Research (2009)

Abstract Background: Basal-like invasive breast cancer has been shown to be associated with a worse prognosis. However, we do not know if basal-like ductal carcinoma in situ (DCIS) relates to a worse prognosis. The purpose of this study was to relate the DCIS basal-like subgroup, evaluated by immunohistochemistry (IHC), with prognosis.Material and Methods: Women diagnosed with a primary DCIS 1986-2004 in Uppsala and Västerås, Sweden were recruited (n=458). TMA blocks were constructed and IHC for Estrogen receptor (ER), Her2, epidermal growth factor receptor (EGFR/Her1) and cytokeratin 5/6 (CK 5/6) was employed to evaluate the gene-expression subgroups. Subtype definitions were as follows: luminal A (ER+ and HER2–), luminal B (ER+ and HER2+), basal-like (ER–, HER2–, CK 5/6+ and/or EGFR+), HER2+ (ER– and HER2+), and others (negative for all markers or data missing).Results: We followed 458 patients for local recurrence, general disease and all-causes mortality. Median follow-up was 122 months. Of the 458 primary DCIS breast cancers, 224 (48.9%) were luminal A subtype, 63 (13.8%) were luminal B, 80 (17.5%) were Her2+, 29 (6.3%) basal-like and 62 (13.5%) unclassified. Local recurrence and general disease rates were similar when comparing basal-like group with each of the other four groups. Compared with the most common luminal A tumors, basal-like tumors were related with poorer survival (hazard ratio 2.56, 95% confidence interval 1.05 – 6.22). When compared with luminal B, Her2+ and unclassified group, basal-like tumors were related with non-significant poorer survival, with a HR (95% CI) of 1.37 (0.52 – 3.64), 1.80 (0.69 – 4.72) and 2.61 (0.61 – 11.2), respectively. We also compared basal-like group with the rest combined as one non-basal-like group. Local recurrence and general disease rates were similar in these two groups. Women with basal-like DCIS had higher mortality than women in the non-basal-like group (HR 2.26, 95% CI 1.00 - 5.10).Conclusion: Basal-like DCIS women may have poorer overall survival, particularly in comparison with luminal A DCIS. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 2114.
Total and subtotal replacement of the common bile duct: effect of transhepatic silicone tube stenting.
Authors: A Cushieri, P R Baker, R J Anderson, M P Holley
Journal: Gut (1983)

The effect of silicone tube stenting on the outcome of total and subtotal replacement of the bile duct with autologous vein was investigated in experiments performed in pigs. All but one of the unstented animals developed dense strictures of the extrahepatic ductal system. This complication was abolished by the use of silicone stents passed transhepatically. The vein autografts in the stented animals underwent progressive shortening with elongation of the distal common bile duct so that beyond four months only one suture line was encountered, and no recognisable venous element was detectable on histological examination. Apart from minor dilatation of the intrahepatic biliary tree encountered in some animals, all the surviving stented animals progressed well and had normal serial liver function tests.
Changes in ethnic minority membership of health authorities 1989-92.
Authors: N Jewson, D Mason, H Bourke, C Bracebridge, F Brosnan, K Milton
Journal: BMJ (1993)

the labour ward, getting started in breast feeding, and willingness to deliver another child later.Mothers' were also asked: Did you have confidence in yourself during your delivery/ confidence in the staff?Did you experience tolerable pain/ intolerable pain/fear that your delivery would not succeed/ fear that your baby would not survive/fear that you would not survive?Did you feel exhausted?Did you feel that your delivery was easier/more difficult than you had expected?Was your childbirth a period ofhappiness/horror?Was the atmosphere at the hospital reception friendly/ encouraging/calm/busy/harsh/nervous/fear inducing and stress inducing/fear reducing and stress reducing?How did you experience your labour pains?How would you assess the atmosphere at the puerperal department?How well did getting breast feeding started succeed?Are you still breast feeding? (At the time of the three month follow up) Would you like to have another baby?PARENTS SOCIODEMOGRAPHIC VARIABLES Age Basic education Vocational education Occupation Estimation about one's own social position.
Commissurotomy for Rheumatic Aortic Stenosis
Authors: C. P. BAILEY, H. E. BOLTON, W. L. JAMISON, H. T. NICHOLS
Journal: Circulation (1954)

As long ago as the middle of 1949 it had been demonstrated by the senior author that any blunt dilating mechanism applied within the stenotic aortic orifice would, upon expansion, force the separation of one or more of the fused commissures. Thus the diminutive valve orifice could be enlarged without the creation of additional insufficiency and with the restoration of such part of the original valve function as the pathologic distortion of the leaflets would permit. In other words the principles and effectiveness of such an aortic commissurotomy would be comparable to those of the similarly named operation for mitral stenosis. It has remained for us finally to develop an instrument and a technic capable of implementing these concepts, and this has at last been accomplished.
Functions and Mechanism of Action of Complement
Authors: Stanley Yachnin
Journal: New England Journal of Medicine (1966)

THE use of the complement-fixation test in serologic investigation serves as a frequent reminder to the physician of the existence of the complement system. It is probable that despite the advances that have taken place in the last decade in knowledge of this complex system, many students still emerge from their medical studies with a somewhat antiquated concept of its nature and importance. For the sake of emphasis one might say that although the complement system may serve to defend the host against invasion by infectious organisms, it may also have an important role as a final common pathway of . . .
"Rheumatic Activity"
Authors: Edward Klibanoff
Journal: JAMA (1966)

Clinical and pathologic evidence of   —as defined by strict, independent criteria—have been correlated in 47 patients who died with rheumatic disease at or below age 30. Pathologic evidence of activity was found in 11 of the 12 patients with clinically active disease, and in 19 of the 33 with clinically inactive disease. Clinical activity was noted in four of the nine patients with Aschoff bodies and in 11 of the 30 with any type of inflammatory histologic infiltrate. Long-term steroid therapy showed no demonstrable effect on the pathologic findings. Although the frequency of clinical and pathologic evidence of   was highest in the younger patients and declined with advancing age, the two types of evidence often did not coexist in the same patient.
Is amoxicillin-cotrimoxazole the most appropriate antibiotic regimen for listeria meningoencephalitis? Review of 22 cases and the literature
Authors: M. Merle-Melet, L. Dossou-Gbete, P. Maurer, Ph. Meyer, A. Lozniewski, O. Kuntzburger, M. Wéber, A. Gérard
Journal: Journal of Infection (1996)
MYXOSPORIDIA IN THE COMMON TOAD WITH PRELIMINARY OBSERVATIONS ON TWO CHROMOPHILE SUBSTANCES IN THEIR SPORES.
Authors: A. P. OHLMACHER
Journal: JAMA (1893)

The myxosporidia belong to the class sporozoa (Leuckart), a sub-division of the sub-kingdom protozoa. The sporozoa are unicellular parasitic organisms, obtaining their nourishment by the absorption of the liquids of their host. This class of parasites is particularly interesting to the pathologist at the present time, because of their supposed causative relation to carcinoma and other neoplasms. The classification of the sporozoa lately adopted by Braun is that of Mingazzini, who divides them into four groups:—1. Gregarinida (including coccidia). 2. Myxosporidia. 3. Sarcosporidia (including microsporidia). 4. Hæmosporidia. From this it will be seen that the myxosporidia form a separate group of the sporozoa, having been set aside in this manner because of certain characteristics peculiar to themselves; and in this grouping, the principal feature which distinguishes the myxosporidia from other sporozoa, is the presence of thread-like flagellæ in their spores. The life history of most of the sporozoa is still
Association of Angiogenesis and Disease Outcome in Node-Positive Breast Cancer Patients Treated With Adjuvant Cyclophosphamide, Doxorubicin, and Fluorouracil: A Cancer and Leukemia Group B Correlative Science Study From Protocols 8541/8869
Authors: Anthony J. Guidi, Donald A. Berry, Gloria Broadwater, Birgit Helmchen, Ira J. Bleiweiss, Daniel R. Budman, I. Craig Henderson, Larry Norton, Daniel F. Hayes
Journal: Journal of Clinical Oncology (2002)

PURPOSE: Increased microvessel density (MVD), a reflection of tumor angiogenesis, is associated with diminished relapse-free and overall survival (OS) in several subsets of breast cancer patients. However, the utility of this assay in node-positive patients treated with adjuvant cyclophosphamide, doxorubicin, and fluorouracil (CAF) has not been well studied. PATIENTS AND METHODS: Immunostaining for factor VIII–related antigen was performed on tissue sections from a subset of node-positive patients who received one of three dose/schedule regimens of CAF during participation in Cancer and Leukemia Group B protocol 8541. Sections from 577 cancers exhibited acceptable tumor and immunostaining quality and were included in the study. Each section was examined quantitatively for MVD as well as nonquantitatively by scoring the presence or absence of a prominent vascular pattern. RESULTS: MVD counts were not associated with relapse-free or OS in univariate analysis. The presence of a prominent plexiform vascular pattern was correlated with decreased OS (P = .0085) in univariate analysis, but this pattern was not an independent prognostic indicator of survival in multivariate analysis. No apparent clinically important interactions between measures of angiogenesis, other prognostic factors, administration of tamoxifen, and chemotherapy dose were observed. CONCLUSION: Assessment of angiogenesis does not provide useful information regarding prognosis in node-positive breast cancer patients treated with adjuvant CAF, nor do these measures predict which patients will benefit from dose intensification or addition of tamoxifen.
Cimetidine and Red-Wine Headaches
Authors: DAVID GLASER
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 March 1983Cimetidine and Red-Wine HeadachesDAVID GLASER, M.D., GEORGE O. DE TARNOWSKY JR., M.D.DAVID GLASER, M.D.Search for more papers by this author, GEORGE O. DE TARNOWSKY JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-3-413_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Many people limit their intake of red wine due to headaches that may occur after consuming even small amounts. Histamine may mediate this effect. We have found that the use of cimetidine before ingesting red wine aborts the unpleasant effect that may occur even with the best vintage. We wonder if others have had this experience.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Fountain Valley Community Hospital Fountain Valley, CA 92708 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySyncope, seizures and stress 1 March 1983Volume 98, Issue 3Page: 413-413KeywordsHistamineWine Issue Published: 1 March 1983 PDF downloadLoading ...
ACUTE KIDNEY INJURY FOLLOWING TRANSCATHETER AORTIC VALVE REPLACEMENT IS ASSOCIATED WITH AN INCREASED RISK OF CHRONIC KIDNEY DISEASE AT 1 YEAR
Authors: Justin Fried, Ben Lerman, Ming Liao, Jacob Kriegel, Eelin Wilson, Jean-Michel Paradis, Philip Green, Ajay Kirtane, Tamim Nazif, Mathew Williams, Isaac George, Martin Leon, Susheel Kodali
Journal: Journal of the American College of Cardiology (2014)
An in vivo study of aortic flow disturbances
Authors: R. M. NEREM, W. A. SEED
Journal: Cardiovascular Research (1972)

Journal Article An in vivo study of aortic flow disturbances Get access R. M. NEREM, R. M. NEREM 2 From the Physiological Flow Studies Unit, Imperial College, London 2 R.M. Nerem received support from the Science Research Council and was on Research Leave from the Department of Aeronautical and Astronautical Engineering, The Ohio State University, Columbus, Ohio, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar W. A. SEED W. A. SEED From the Physiological Flow Studies Unit, Imperial College, London Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 6, Issue 1, January 1972, Pages 1–14, https://doi.org/10.1093/cvr/6.1.1 Published: 01 January 1972
The Biogun: A Novel Way of Eradicating Methicillin-Resistant <i>Staphylococcus Aureus</i> Colonization in Diabetic Foot Ulcers
Authors: Benjamin A. Lipsky
Journal: Diabetes Care (2006)

I applaud the novel approach used by Dang et al. (1) to eradicate methicillin-resistant Staphylococcus aureus (MRSA) in patients with a diabetic foot ulcer. These Manchester Royal Infirmary clinicians have been leaders in documenting the problem of MRSA in diabetic foot lesions. As the incidence of colonization and subsequent infection with this virulent pathogen …
Hormonal and hemodynamic profile of an anaphylactic reaction in man.
Authors: J Moss, N R Fahmy, N Sunder, M A Beaven
Journal: Circulation (1981)

A 28-year-old female undergoing elective total hip replacement experienced an anaphylactic reaction to succinylcholine. Hemodynamics, plasma histamine and catecholamines were measured. The tachycardia experienced during the reaction appeared to be secondary to the sympathoadrenal response rather than a direct chronotropic effect of histamine.
Use of personal child health records in the UK: findings from the millennium cohort study
Authors: Suzanne Walton, Helen Bedford, Carol Dezateux
Journal: BMJ (2006)

The personal child health record (PCHR) is a record of a child's growth, development, and uptake of preventive health services, designed to enhance communication between parents and health professionals. We examined its use throughout the United Kingdom with respect to recording children's weight and measures of social disadvantage and infant health.Cross sectional survey within a cohort study.UK.Mothers of 18,503 children born between 2000 and 2002, living in the UK at 9 months of age.Proportion of mothers able to produce their child's PCHR; proportion of PCHRs consulted containing record of child's last weight; effective use of the PCHR (defined as production, consultation, and child's last weight recorded).In all, 16,917 (93%) mothers produced their child's PCHR and 15,138 (85%) mothers showed effective use of their child's PCHR. Last weight was recorded in 97% of PCHRs consulted. Effective use was less in children previously admitted to hospital, and, in association with factors reflecting social disadvantage, including residence in disadvantaged communities, young maternal age, large family size (four or more children; incidence rate ratio 0.87; 95% confidence interval 0.83 to 0.91), and lone parent status (0.88; 0.86 to 0.91).Use of the PCHR is lower by women living in disadvantaged circumstances, but overall the record is retained and used by a high proportion of all mothers throughout the UK in their child's first year of life. PCHR use is endorsed in the National Service Framework for Children and has potential benefits which extend beyond the direct care of individual children.
<scp>l</scp> -Arginine Reduces Human Monocyte Adhesion to Vascular Endothelium and Endothelial Expression of Cell Adhesion Molecules
Authors: Mark R. Adams, Wendy Jessup, Deborah Hailstones, David S. Celermajer
Journal: Circulation (1997)

Background Monocyte adhesion to endothelial cells is a key early event in atherogenesis. Because l -arginine has been shown to reduce atheroma and to decrease monocyte–endothelial cell adhesion in an animal model of atherosclerosis, we studied the effects of l -arginine on human monocyte adhesion to human endothelial cells and endothelial expression of cell adhesion molecules. Methods and Results Human umbilical vein endothelial cells (HUVECs) were grown to confluence, then incubated for 24 hours with arginine-deficient media to which was added saline (control), 100 or 1000 μmol/L l -arginine, 100 μmol/L d -arginine, 100 μmol/L N G -monomethyl- l -arginine (L-NMMA), or 100 μmol/L l -arginine with 100 μmol/L L-NMMA. Human monocytes obtained by elutriation were incubated for 1 hour with HUVECs, and adhesion was measured by light microscopy. Compared with control, monocyte adhesion was reduced by l -arginine (59±10%, P =.01) and increased by L-NMMA (123±20%, P =.01). Surface expression of cell adhesion molecules by HUVECs was assessed by an ELISA under the above conditions with and without stimulation with interleukin-1β. Expression of ICAM-1 was reduced with both concentrations of l -arginine compared with control in both the basal (43±12%, P &lt;.01), and stimulated (46±15%, P &lt;.01) states, which correlated with decreased levels of mRNA. Expression of VCAM-1 was reduced only in the stimulated state and only in the presence of 1000 μmol/L l -arginine (72±24%, P =.02). Conclusions l -Arginine reduces human monocyte adhesion to endothelial cells and decreases expression of certain endothelial cell adhesion molecules.
Epicene Pronouns—Obliterate, Slash, or Pluralize?-Reply
Authors: Patricia Lorimer-Lundberg
Journal: JAMA (1988)

<h3>In Reply.—</h3> I agree with Drs Lewis and Schoen that slashed pronouns such as<i>he/she</i>jar the reader and that<i>he or she</i>used too much is equally annoying, as Dr Lewis so wittingly demonstrates in paragraph four of his letter. I also advocate the plural pronoun as the preferred epicene. Rather than offending the purity of the English language, using plural pronouns with singular antecedents has always been standard—in British English. Otto Jesperson,<sup>1</sup>a great grammarian, long ago approved such usage and cited many renowned authors whose writing reflects it. American grammar books, curiously more prescriptive than their British counterparts, only recently have softened their pedantic (<i>not</i>purist) stances against such usage. Thomas Pyles,<sup>2,3</sup>John Algeo,<sup>3</sup>and George Jochnowitz<sup>4</sup>are a few of the language authorities who have jumped (without injury) on the plural-pronoun/singular-antecedent bandwagon, as that venerable dictator of the American English language, the
Solitary Hepatic Metastasis From Medullary Thyroid Carcinoma Mimicking Atypical Hemangioma
Authors: Alessio Imperiale, Michel Greget, Gérard Chabrier, Julie Keomany, Edmond Rust, Julien Detour, Patrick Pessaux, Bernard Goichot
Journal: Clinical Nuclear Medicine (2010)

Medullary thyroid carcinoma (MTC) is an uncommon malignant endocrine tumor. Distant metastases occur frequently in patients with elevated serum calcitonin values. Surgery remains the mainstay of treatment, so the early detection of metastatic involvement is crucial for patient outcome. F-18 FDOPA PET/CT seems to be a promising diagnostic tool for disease recurrence detection. We report the results of multimodality diagnostic approach by MRI, F-18 FDG, and F-18 FDOPA PET/CT in a patient with a solitary hepatic metastasis from MTC mimicking atypical hemangioma.
Submucosal hemorrhage in the descending duodenum: endoscopic findings of acute severe pancreatitis
Authors: S. Alexander, M. Bourke, J. Co, S. Williams, A. Bailey
Journal: Endoscopy (2008)

A 56-year-old man whose history was significant only for obesity (body mass index 34) presented with severe acute gallstone pancreatitis and cholangitis. His condition deteriorated, despite maximum supportive measures including intravenous antibiotics, and he soon required admission to intensive care. A noncontrast CT scan (because of renal failure) revealed marked peripancreatic fat stranding in keeping with acute pancreatitis. An emergency endoscopic retrograde cholangiopancreatography (ERCP) 36 hours after admission revealed severely edematous and hemorrhagic duodenal mucosa around the papilla, both above and below, over an 8-cm extent on the medial wall with contact bleeding ([Fig. 1]). The ampulla was difficult to identify or view en face but was successfully cannulated and biliary sphincterotomy performed ([Fig. 2]). The duct was swept, delivering sludge without discrete stone. A 7F, 7-cm double pigtail stent (ZSO-7 – 7; Cook Australia, Brown Plains, Brisbane, Queensland, Australia) was inserted to ensure continued adequate drainage given the severity of the mucosal edema ([Fig. 3]). Rapid resolution of symptoms followed and the patient was discharged on day 23. ERCP 6 weeks later revealed multiple small common bile duct stones that had presumably passed in the interim. Cholecystectomy is planned.
Methadone Maintenance-Reply
Authors: David M. Novick
Journal: JAMA (1988)

<h3>In Reply.—</h3> Drs Kell and Techman treat methadone maintenance patients in a private clinic with substantial involvement by physicians, who see the patients at least once per week and personally dispense medication. We applaud this degree of physician involvement and we agree that approaches using psychotherapy and self-help, as exemplified by Alcoholics Anonymous,<sup>1</sup>can be useful for individual methadone maintenance patients. Nevertheless, we believe that our article on the treatment of stable, long-term methadone maintenance patients by hospital-based physicians, has been misinterpreted. First, we disagree that dispensing a 28-day supply of take-home medication to patients who have demonstrated years of responsible behavior is a liability. Diversion of methadone for resale is extremely unlikely because our patients take a dose of methadone in the physician's office to ensure tolerance. Also, few incidents of lost medication have occurred, and our patients all have legitimate sources of income. Second, the description of
Researchers "disappointed" that influential study was not retracted
Authors: Z. Kmietowicz
Journal: BMJ (2014)

Researchers have described as “disappointing” a journal’s decision not to retract a paper that they said was skewing the results of meta-analyses and had made guidelines on protecting the heart of patients undergoing surgery unreliable and dangerous.

Graham Cole and Darrel Francis, of Imperial College London, called for the New England Journal of Medicine to retract a research paper by Don Poldermans on the use of β blockers to reduce the risk of myocardial infarction in patients having high risk surgery1 after they published an analysis of the research in The BMJ on 29 August this year.2

Poldermans, a prominent professor of perioperative cardiovascular care at Rotterdam’s Erasmus Medical Centre, was suspended from his post in 2010 after a junior researcher raised concerns about studies he had led for 10 years, called the Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echo (DECREASE) studies. In 2011 Poldermans was dismissed for “serious violations of scientific integrity” in his research and found guilty of research misconduct, although this was not specific to the DECREASE I study,3 on which Cole and Francis have focused.

The DECREASE I study, which included 112 patients, found that the β blocker bisoprolol reduced the …