tbuckley/cabot-search huggingface dataset:
Impaired Collateral Vessel Development Associated With Reduced Expression of Vascular Endothelial Growth Factor in ApoE <sup>−/−</sup> Mice
Authors: Thierry Couffinhal, Marcy Silver, Marianne Kearney, Alison Sullivan, Bernhard Witzenbichler, Meredith Magner, Brian Annex, Kevin Peters, Jeffrey M. Isner
Journal: Circulation (1999)

Background —The impact of disordered lipid metabolism on collateral vessel development was studied in apolipoprotein (apo)E −/− mice with unilateral hindlimb ischemia. Methods and Results —Hindlimb blood flow and capillary density were markedly reduced in apoE −/− mice versus C57 controls. This was associated with reduced expression of vascular endothelial growth factor (VEGF) in the ischemic limbs of apoE −/− mice. Cell-specific immunostaining localized VEGF protein expression to skeletal myocytes and infiltrating T cells in the ischemic limbs of C57 mice; in contrast, T-cell infiltrates in ischemic limbs of apoE −/− mice were severely reduced. The critical contribution of T cells to VEGF expression and collateral vessel growth was reinforced by the finding of accelerated limb necrosis in athymic nude mice with operatively induced hindlimb ischemia. Adenoviral VEGF gene transfer to apoE −/− mice resulted in marked augmentation of hindlimb blood flow and capillary density. Conclusions —These findings thus underscore the extent to which hyperlipidemia adversely affects native collateral development but does not preclude augmented collateral vessel growth in response to exogenous cytokines. Moreover, results obtained in the apoE −/− and athymic nude mice imply a critical role for infiltrating T cells as a source of VEGF in neovascularization of ischemic tissues.
Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD): Explanation and Elaboration
Authors: Karel G.M. Moons, Douglas G. Altman, Johannes B. Reitsma, John P.A. Ioannidis, Petra Macaskill, Ewout W. Steyerberg, Andrew J. Vickers, David F. Ransohoff, Gary S. Collins
Journal: Annals of Internal Medicine (2015)

The TRIPOD (Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis) Statement includes a 22-item checklist, which aims to improve the reporting of studies developing, validating, or updating a prediction model, whether for diagnostic or prognostic purposes. The TRIPOD Statement aims to improve the transparency of the reporting of a prediction model study regardless of the study methods used. This explanation and elaboration document describes the rationale; clarifies the meaning of each item; and discusses why transparent reporting is important, with a view to assessing risk of bias and clinical usefulness of the prediction model. Each checklist item of the TRIPOD Statement is explained in detail and accompanied by published examples of good reporting. The document also provides a valuable reference of issues to consider when designing, conducting, and analyzing prediction model studies. To aid the editorial process and help peer reviewers and, ultimately, readers and systematic reviewers of prediction model studies, it is recommended that authors include a completed checklist in their submission. The TRIPOD checklist can also be downloaded from www.tripod-statement.org.
Cancer Research: The Great Debate
Authors: Alexander Haddow
Journal: New England Journal of Medicine (1971)

I deem it a particular honor to have been invited by the Editor to pen these lines for the New England Journal of Medicine, considering especially the high regard and indeed affection in which the Journal is held not only in the United States and Britain but also throughout the world. I was invited to submit a considered personal view of the great debate now engaging at once American medicine and science, American politics and the entire American people, whether on the one hand cancer research should now be activated through a highly coordinated and directed effort virtually taking the form . . .
Identifying hypoxaemia in children admitted for adenotonsillectomy.
Authors: V. H. van Someren, J. Hibbert, J. K. Stothers, M. C. Kyme, G. A. Morrison
Journal: BMJ (1989)

equivalent to drinking two and a half times as many cups of coffee or tea each day as usual.If there is a dose response relation between coffee consumption and coronary heart disease or low birthweight babies, as seems to be the case, and that risk is mediated by caffeine then smokers who abstain would be at con- tinuing high risk because of their caffeine consumption.Doctors offering antismoking treatment should advise patients that continued consumption of coffee at the same level may exacerbate the tobacco withdrawal syndrome and contribute to increased health risks; these patients should reduce their consumption.
The effect of the antiandrogen IIα-hydroxyprogesterone on sebum production and cholesterol concentration of sebum
Authors: J. TAMM, M. SECKELMANN, U. VOLKWEIN, E. LUDWIG
Journal: British Journal of Dermatology (1982)

Journal Article The effect of the antiandrogen IIα‐hydroxyprogesterone on sebum production and cholesterol concentration of sebum Get access J. TAMM, J. TAMM Department of Medicine, University of Hamburg, West Germany Prof. J. Tamm, Medizinische Universitatsklinik, D‐2000 Hamburg 20, F.R.G. Search for other works by this author on: Oxford Academic Google Scholar M. SECKELMANN, M. SECKELMANN Department of Medicine, University of Hamburg, West Germany Search for other works by this author on: Oxford Academic Google Scholar U. VOLKWEIN, U. VOLKWEIN Department of Medicine, University of Hamburg, West Germany Search for other works by this author on: Oxford Academic Google Scholar E. LUDWIG E. LUDWIG Department of Dermatology, University of Hamburg, West Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 107, Issue 1, 1 July 1982, Pages 63–70, https://doi.org/10.1111/j.1365-2133.1982.tb00291.x Published: 01 July 1982 Article history Accepted: 29 September 1981 Published: 01 July 1982
DAP12-Deficient Mice Fail to Develop Autoimmunity Due to Impaired Antigen Priming
Authors: Alexander B.H. Bakker, Robert M. Hoek, Adelheid Cerwenka, Bianca Blom, Linda Lucian, Tom McNeil, Richard Murray, Joseph H. Phillips, Jonathon D. Sedgwick, Lewis L. Lanier
Journal: Immunity (2000)
AIDS Giving Rise to Cardiac Problems
Authors: Paul Cotton
Journal: JAMA (1990)

A HIDDEN WAVE of heart disease could surface as the human immunodeficiency virus (HIV) epidemic continues to evolve. An accurate assessment of incidence has not been made, says the Centers for Disease Control, Atlanta, Ga. But more than 150 reports on acquired immunodeficiency syndrome (AIDS)-related heart complications are in the scientific literature. Pathologists are finding inflammation, myopathy, and neoplasms in as many as two thirds of autopsies on patients with AIDS. The rates are lowest among white homosexual men and highest in the nonwhite and intravenous drug—using populations through which the epidemic is now spreading. "We feel that cardiac problems might emerge" (become symptomatic) during the increased survival time resulting from advances in treating the opportunistic infections that cause most AIDS-related deaths, says Constance Weinstein, PhD, chief of the cardiac diseases branch of the National Heart, Lung, and Blood Institute, Bethesda, Md (NHLBI). A review in the April 1989 issue
HIGH PREVALENCE OF OSTEOCHONDRAL AND SOFT-TISSUE DAMAGE IN THE ANKLES OF ASYMPTOMATIC PROFESSIONAL SNOWBOARDERS: A PROSPECTIVE EVALUATION WITH 3T MRI
Authors: K Briggs, C Ho, W Ryan, G Bower, T Hackett, T Clanton
Journal: British Journal of Sports Medicine (2014)

Background Professional snowboarders are exposed to repetitive high-impact loading on a daily basis throughout their competitive and training careers. Objective The purpose of this study was to determine the prevalence of ankle derangements on magnetic resonance imaging (MRI) in asymptomatic professional snowboarding athletes. We hypothesized that elite snowboarders with asymptomatic ankles would exhibit osteochondral and soft-tissue changes on 3T MRI. Design Between February and March 2013, professional snowboarders specializing in various disciplines were recruited to participate in the study. 3T MRIs of each ankle were obtained prospectively. Setting World Cup snowboarding competition. Participants Each participant underwent a physical examination of each ankle and completed a short survey including demographic, pain, and functional questions prior to MRI evaluation to ensure that each of the included ankles were truly asymptomatic. Sixteen professional snowboarders (29 asymptomatic ankles) were included in the study. Risk factor assessment A 3T MRI scan of each asymptomatic ankle was performed. Main outcome measurements The MRI findings were recorded by an experienced musuloskeletal radiologist. Results There were 9 males (16 ankles) and 7 females (13 ankles) with a mean age of 23.4 years (range, 18–31 years) who had been professional snowboarders for a median of 6.5 years (range, 2–15 years). It was found that all 29 ankles (100%) had notable derangements on 3T MRI scans including various ligamentous pathologies, tendinous pathologies, syndesmosis injuries, effusions, osteochondral injuries and bony edema. Increasing age and years of competitive snowboarding were significantly associated with chondral damage of the ankle (P=.017 and P=.026, respectively). Conclusion All 29 asymptomatic ankles in this study had notable derangements on MRI scans, signifying a potentially high prevalence of asymptomatic ankle pathology in elite snowboarding athletes. Recognition of these injuries is important to create future strategies for the prevention of long-term sequelae in this high-risk group.
Hearing Deficits in the Older Patient
Authors: James T. Pacala, Bevan Yueh
Journal: JAMA (2012)

Hearing loss is common in older adults. Patients, clinicians, and health care staff often do not recognize hearing loss, particularly in its early stages, and it is undertreated. Age-related hearing loss or presbycusis, the most common type of hearing loss in older adults, is a multifactorial sensorineural loss that frequently includes a component of impaired speech discrimination. Simple office-based screening and evaluation procedures can identify potential hearing disorders, which should prompt audiologic referral to confirm the diagnosis with audiometric testing. The mainstay of treatment is amplification. For many older adults, accepting the need for amplification, selecting and purchasing a hearing aid, and getting accustomed to its use is a daunting and often frustrating process. There are numerous barriers to hearing aid use, the most common of which is dissatisfaction with its performance across a range of sonic environments. Newer digital hearing aids have many features that improve performance, making them potentially more acceptable to users, but they are expensive and are not covered by Medicare. Hearing aids have been demonstrated to improve hearing function and hearing-related quality of life (QOL), but evidence is less robust for improving overall QOL. Depending upon the etiology of the hearing loss, other medical and surgical procedures, including cochlear implantation, may benefit older adults. Older adults with multiple morbidities and who are frail pose specific challenges for the management of hearing loss. These patients may require integration of hearing assessment and treatment as part of functional assessment in an interdisciplinary, team-based approach to care.
Abstract LB-8: Tumor suppressive functions of leucine zipper transcription factorlike 1
Authors: Wei Qun, Wen Zhou, Weining Wang, Boning Gao, Jiang Cao, LinBo Wang, Zhi-ping liu
Journal: Cancer Research (2010)

Abstract Human leucine zipper transcription factor like 1 (LZTFL1) is a novel gene with unknown biological functions. It is located in the chromosome region 3p21.3, a hot spot for tumor suppressor genes. To understand the biological functions of LZTFL1, we surveyed the expression level of LZTFL1 in tumor and normal samples in tissue microarrays and a clinical archive of 84 gastric cancer specimens using immunohistochemistry. We found that LZTFL1 is expressed highly in the epithelial cells of normal tissues and is significantly down regulated in the corresponding tumor samples. The expression level of LZTFL1 correlated significantly with the survival outcomes of the patients and had significant inverse correlation with tumor metastasis. Overexpression of LZTFL1 in tumor cells inhibited anchorage-independent cell growth and cell migration in vitro, and repressed tumor growth in vivo. Furthermore, we show that LZTFL1 expression is upregulated upon epithelial cell differentiation and is graded along the crypt-villus axis of the intestine with weakest expression level in the proliferative zone of the crypt and highest expression level at the apex of the differentiation zone in the villus. Expression of LZTFL1 overlaps with that of E-cadherin at the plasma membrane. Our results indicate that LZTFL1 is a tumor suppressor and that loss of LZTFL1 expression has significant clinical outcomes. LZTFL1 expression may serve as an independent prognostic marker for survival outcome of gastric cancer patients. We propose that LZTFL1 may inhibit tumorigenesis by stabilizing E-cadherin-mediated adherens junction formation and promoting epithelial cell differentiation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-8.
Local, non-viral IL-12 gene therapy using a water soluble lipopolymer as carrier system combined with systemic paclitaxel for cancer treatment
Authors: Margit Maria Janát-Amsbury, James W. Yockman, Minhyung Lee, Steven Kern, Darin Y. Furgeson, Malavosklish Bikram, Sung Wan Kim
Journal: Journal of Controlled Release (2004)
Adolescent Suicide Attempts
Authors: Frank E. Crumley
Journal: JAMA (1979)

The conditions of 40 adolescents in treatment following a suicide attempt were diagnosed according to the multiaxial classification of the American Psychiatric Association's proposed third edition of the diagnostic and statistical manual. All were psychiatrically ill before the suicide attempt. The most common diagnoses were those of depressive disorders and substance abuse disorders on the clinical psychiatric syndrome axis and borderline personality disorder on the personality and developmental disorder axis. The typical patient was a polydrug-abusing girl with a borderline personality disorder and a superimposed major depressive disorder. The most prominent personality characteristics associated with suicide attempts by these adolescents were a tendency to react severely to a loss, poorly controlled rage, and impulsivity. Suicide attempts by adolescents should be taken seriously by the physician and necessitate a thorough search for a possible underlying pathological condition.
Chemical Keratoconjunctivitis from a “Foam Party”
Authors: J. Christian Cather, Richard W. Yee, H. Kilimanjaro-Davis
Journal: New England Journal of Medicine (1996)

To the Editor: Professor Annas says, "U.S. Presidents have always been more likely to be killed or disabled by assassins than by diseases."He seems to have miscounted.The assassinated presidents were Lincoln, Kennedy, Garfield, and McKinley.Those who died of diseases in office were F
Adult human heart microvascular endothelial cells are permissive for non-lytic infection by human cytomegalovirus
Authors: D Ricotta
Journal: Cardiovascular Research (2001)

Human cytomegalovirus (CMV) infection has been linked to chronic heart disease. The mechanism of CMV dissemination to the heart remains unknown. CMV antigens and nucleic acid sequences have been detected in endothelial cells (ECs) in vivo, and ECs are fully permissive hosts to CMV replication in vitro. This report examines the characteristics of CMV replication in primary cultures of human heart microvascular ECs (HHMECs).Capillary ECs were isolated from heart tissue biopsies of six patients at the time of heart surgery. HHMECs were infected with CMV and viral antigens were detected by immunofluorescence assay using monoclonal antibodies as specific reagents. Cytokine and chemokine release in the supernatant of sham- and CMV-infected cells was quantitated by ELISA. Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to analyse expression of mRNA for adhesion molecules.CMV was found to productively infect HHMECs without cytolytic effects. Infected cultures released high levels of pro-inflammatory chemokines and enhanced their adhesion molecule expression.Our data provide new insights into the mechanism of CMV dissemination to the heart, signalling the need for further investigation of the pathogenetic role of this virus in cardiac disorders.
DOES THE GUINEA-WORM OCCUR IN NORTH AMERICA?
Authors: B. G. CHITWOOD
Journal: JAMA (1933)

The guinea-worm, Dracunculus medinensis, has been reported from man in North America in a total of ten published cases. In four of the cases, D. medinensis was collected from persons who had been abroad in countries in which guinea-worm is known to be endemic and who either certainly or possibly became infested while abroad. In six other cases the evidence published in connection with the cases indicates that the supposed D. medinensis was actually something else. The net result of a consideration of the published literature is a total lack of human cases that can be accepted as originating in the United States. The four cases of D. medinensis infestation reported from the United States with evidence that the infestation was or might have been acquired abroad, are as follows: Severance<sup>1</sup>reported a case in a white sailor who had been in Mogador, Morocco, six years previously. The worm
Selective intestinal decontamination with norfloxacin reduces bacterial translocation in ascitic cirrhotic rats exposed to hemorrhagic shock
Authors: J M Llovet, R Bartoli, R Planas, B Vinado, J Perez, E Cabre, J Arnal, I Ojanguren, V Ausina, M A Gassull
Journal: Hepatology (1996)

Bacterial translocation (BT) can be involved in the pathogenesis of severe infections due to bacteria of enteric origin that complicates bleeding cirrhotic patients. To assess the effect of hemorrhagic shock (HS) on the incidence of BT and if selective intestinal decontamination (SID) reduces this incidence, we studied six groups of Sprague-Dawley rats: ascitic rats, ascitic rats exposed to HS with and without previous norfloxacin prophylaxis, healthy rats, and healthy shocked rats with and without previous norfloxacin prophylaxis. BT tended to be higher in ascitic rats with shock than without shock (69% vs. 41%, P = .15) and was significantly higher in healthy rats with than without shock (50 percent vs. 0 percent, P = .01). Norfloxacin significantly reduced translocation in ascitic shocked rats in comparison with nondecontaminated ascitic shocked rats (31 percent vs. 69 percent, P = .038). This effect was due mainly to a reduction of gram-negative BT (O percent vs. 37 percent, P = .008). In addition, norfloxacin prevented translocation in healthy shocked rats. Accordingly, aerobic gram-negative bacteria disappeared from fecal flora in all rats administered norfloxacin, except for Klebsiella species in one control rat. Cecal severe submucosal edema, chronic inflammatory infiltrate, and intestinal lymphangiectasia were significantly more frequent in ascitic rats than in control rats. Intestinal mucosal injury related with HS, particularly subepithelial cecal edema, was observed only in ascitic shocked rats. In conclusion, HS increases the incidence of BT both in ascitic cirrhotic and healthy rats. Norfloxacin reduces significantly the incidence of translocation after shock, especially in those cases caused by aerobic gram-negative bacilli.
962 ETIOLOGY OF HBSAG- and ANTI-HCV-NEGATIVE HEPATOCELLULAR CARCINOMA IN KOREA: PRIOR HBV INFECTION OR METABOLIC SYNDROME?
Authors: E.J. Cho, E.S. Jang, M.S. Kwak, S.J. Yu, J.-H. Lee, J.-H. Yoon, H.-S. Lee
Journal: Journal of Hepatology (2011)
CONTAGION IN LEPROSY AS OBSERVED IN SAN FRANCISCO.
Authors: DOUGLASS W. MONTGOMERY
Journal: JAMA (1900)

There are quite a number of lepers in San Francisco, many more than the eighteen or nineteen who are at present in the pest-house. The important question, however, before the city itself and before the United States is whether San Francisco and the Pacific Coast is merely a temporary abiding place for a few lepers who have come to it by accident, or whether this part of the United States is really becoming a leper focus where the disease may be contracted. The difference between these two conditions is very great. London, Paris and Berlin, for instance, have always a number of lepers who have come to them either as returned officials or merchants who have acquired their disease in a leper country, such as Tonquin or India, or as patients seeking medical advice, but it is not considered that any of these cities constitute leper centers where leprosy is
How to interpret the eGFR in patients with small body surface area
Authors: EelG-You Park, Think-You Kim
Journal: Kidney International (2009)

To the Editor: We agreed with Freedberg's1.Freedberg D.E. To eGFR or not to eGFR: here is an intern's answer.Kidney Int. 2009; 76: 129-130Abstract Full Text Full Text PDF PubMed Scopus (6) Google Scholar article, which proposed the importance of muscle mass in evaluating each individual's GFR, and that creatinine clearance (Ccr) using 24-h urine is more useful than estimated GFR (eGFR) in hospitals. However, we were a little surprised at the author for expressing the unit of Ccr as ml/min (Ccr-I) rather than as ml/min per 1.73 m2 (Ccr-II). We applied a modified version of the Bland–Altman plot on Ccr and eGFR to determine whether their differences change according to body surface area (BSA).2.Bland J.M. Altman D.G. Statistical methods for assessing agreement between two methods of clinical measurement.Lancet. 1986; 327: 307-310Abstract Scopus (39376) Google Scholar For eGFR, we used the four-variable Modification of Diet in Renal Disease study equation using the Japanese race factor.3.Imai E. Horio M. Nitta K. et al.Estimation of glomerular filtration rate by the MDRD study equation modified for Japanese patients with chronic kidney disease.Clin Exp Nephrol. 2007; 11: 41-50Crossref PubMed Scopus (467) Google Scholar Among 253 patients with ages above 18 years, 160 patients having Ccr-II of greater than 60 ml/min per 1.73 m2 were selected for the measurement of Ccr-I, Ccr-II, and eGFR (Figure 1a and b). We also measured Ccr-I, Ccr-II, and eGFR for 93 patients having a Ccr-II of less than 60 ml/min per 1.73 m2 (Figure 1c and d). In patients with Ccr-II greater than 60 ml/min per 1.73 m2, eGFR became less than Ccr-I or Ccr-II above the BSA value of approximately 1.73 m2, whereas it became greater in the opposite case. However, such a phenomenon was less seen in patients with a Ccr-II of less than 60 ml/min per 1.73 m2 and disappeared statistically between Ccr-II and eGFR. However, as there were a few cases that showed very big differences between Ccr-II and eGFR with a small BSA, caution should be exercised applying eGFR to an individual patient.