In response: Prophylaxis of Pneumocystis Pneumonia and Toxoplasmosis
Authors: Daniel Podzamczer
Journal: Annals of Internal Medicine (1996)

Letters15 June 1996In response: Prophylaxis of Pneumocystis Pneumonia and ToxoplasmosisDaniel Podzamczer, MD and Francisco Gudiol, MDDaniel Podzamczer, MDUniversity of Barcelona, Barcelona 08907, SpainSearch for more papers by this author and Francisco Gudiol, MDUniversity of Barcelona, Barcelona 08907, SpainSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-12-199606150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Because immunosuppressed HIV-infected patients must take many medications for the management of acquired immunodeficiency syndrome (AIDS)-associated diseases in addition to antiretroviral therapy, intermittent regimens for the prophylaxis of opportunistic infections such as Pneumocystis carinii pneumonia and toxoplasmosis may help to improve quality of life and may prolong survival.Several intermittent regimens, however, have proven insufficient to adequately prevent opportunistic infections [1-4]. In addition, because compliance in these patients is a matter of concern, regimens with a “safety margin” sufficient to retain their effectiveness despite irregular compliance are preferable.We agree with Zamora and colleagues that intermittent low-dose regimens ...References1. Podzamczer D, Santin M, Jimenez J, Casanova A, Bolao F, Rufi G, et al. Thrice-weekly cotrimoxazole is better than weekly dapsone-pyrimethamine for the primary prevention of Pneumocystis carinii pneumonia in HIV-infected patients. AIDS. 1993; 7:501-6. Google Scholar2. Antinori A, Murri R, Tamburrini E, De Luca A, Ortona L. Failure of low-dose dapsone-pyrimethamine in primary prophylaxis of Pneumocystis carinii pneumonia [Letter]. Lancet. 1992; 340:788. Google Scholar3. Coker RJ, Nieman R, McBride M, Mitchell DM, Harris JR, Weber JN. Co-trimoxazole versus dapsone-pyrimethamine for prevention of Pneumocystis carinii pneumonia [Letter]. Lancet 1992; 340:1099. Google Scholar4. Podzamczer D, Miro M, Bolao F, Gatell JM, Cosin J, Sirera G, et al. Twice-weekly maintenance therapy with sulfadiazine-pyrimethamine to prevent recurrent toxoplasmic encephalitis in patients with AIDS. Ann Intern Med. 1995; 123:175-80. Google Scholar5. Podzamczer D, Salazar A, Jimenez J, Consiglio E, Santin M, Casanova A, et al. Intermittent trimethoprim-sulfamethoxazole compared with dapsone-pyrimethamine for the simultaneous primary prophylaxis of pneumocystis pneumonia and toxoplasmosis in patients infected with HIV. Ann Intern Med. 1995; 122:755-61. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Barcelona, Barcelona 08907, Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1996Volume 124, Issue 12Page: 1096KeywordsOpportunistic infectionsPneumocystisPneumocystis carinii pneumoniaPneumoniaProphylaxisPyrimethamineQuality of lifeSafetyToxoplasmosis Issue Published: 15 June 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...