tbuckley/cabot-search huggingface dataset:
IgE antibodies to Hymenoptera venoms in the serum are common in the general population and are related to indications of atopy
Authors: T. Schäfer, B. Przybilla
Journal: Allergy (1996)

Determination of Hymenoptera venom (HV)-specific serum IgE antibodies is a useful diagnostic method in patients with systemic anaphylactic reaction (SAR) to Hymenoptera stings. In a general population cohort, we determined the prevalence of SAR and HV-specific IgE antibodies and assessed parameters associated with the latter. A total of 277 voluntarily participating inhabitants of rural Bavaria (Germany) (232 adults, mean age 38.0 years; 45 children, mean age 8.4 years) were investigated for a history of atopic disease or SAR to insect stings; in 258 of these, total IgE and specific IgE antibodies to HV (Apis mellifera, Vespula vulgaris/germanica) and four common aeroallergens (birch pollen, grass pollen, house-dust mite, and cat dander) in the serum were determined. Nine (3.3%) subjects reported SAR to insect stings. In 27.1% of the sera, specific IgE antibodies to HV were found, to bee venom in 24.8%, and to wasp venom in 8.5% (P < 0.0001). Of those exhibiting HV-specific IgE, 7.1% reported SAR to insect stings. A personal history of atopic disease (hay fever, asthma, or atopic eczema) was present in 16.7%, specific IgE to common aeroallergens was found in 32.6%, and total IgE > 100 kU/l was found in 22.5%. Specific serum IgE to HV was significantly associated with male sex (female vs. male, OR = 0.47; CI 0.25-0.86), young age (children vs. adults, OR = 2.80; CI 1.25-6.28), a history of SAR to insect stings (OR = 4.16; CI 1.15-15.03), total sIgE > 100 kU/l (OR = 3.88; CI 1.98-7.60), and specific IgE antibodies to three of the four aeroallergens (grass pollen, OR = 7.24 CI 3.66-14.38; birch pollen, OR = 3.67 CI 1.54-8.81; and house-dust mite, OR = 4.61 CI 2.08-10.32). It is concluded that immunologic sensitization to HV is common in the general population and is associated with atopy-related humoral IgE hyperresponsiveness.
In Vitro Model Systems for the Study of Hormone-Dependent Human Breast Cancer
Authors: Howard L. Bleich, Emily S. Boro, Marc E. Lippman, C. Kent Osborne, Richard Knazek, Nathaniel Young
Journal: New England Journal of Medicine (1977)

The hormone-dependent nature of some human breast cancers has been appreciated since the pioneering work of Beatson more than 75 years ago.1 Since then, a variety of ablative and additive therapies have been used to induce clinically important palliations in patients with metastatic breast cancer. Such tumor regressions have also been duplicated in several animal-model systems — notably, in rats with dimethylbenz(a)anthracene-induced mammary cancer.2 Nonetheless, the data accumulated in clinical and animal studies have failed to define the mechanisms whereby adrenalectomy, hypophysectomy or treatment with androgens, estrogens, progestins or glucocorticoids leads to tumor regression in some patients. In vivo studies . . .
Problems of Accident and Emergency Services
Authors: R. Howard
Journal: BMJ (1967)

A bovm" levels.Major differences were noted between the two groups in respect of amount of penicillin administered and penicillin C.S.F.concentration; the group with fits tended to have lower serum sodium values than those without fits.No patient with a lumbar C.S.F.penicillin concentration less than 10 units/ml.had a fit; clearly, whatever the state of renal function or the blood/C.S.F.barrier it is unwise to exceed this concentra- tion of penicillin in the C.S.F.The other complications of infusion of large doses of penicillin G are fluid and electrolyte im- balance, which can be avoided or corrected, and haemolytic anaemia, which is quite rare.Intravenous penicillin G in doses of 20 to 100 million units per 24 hours is not only a useful form of therapy for septicaemia due to Clostridium welchis and selected Gram- negative species but may be the only effective therapy in certain patients with endocarditis.For those who may wish to administer these doses it is important that indiscriminate, use is avoided and that the limitation of dosage based on C.S.F.penicillin levels be under- stood.
Carpal Tunnel Syndrome Secondary to Carpopedal Spasm
Authors: E W Massey, J T O'Brian, L P Georges
Journal: Annals of Internal Medicine (1978)

Brief Reports1 June 1978Carpal Tunnel Syndrome Secondary to Carpopedal SpasmE. WAYNE MASSEY, JOHN T. O'BRIAN, LEON P. GEORGESE. WAYNE MASSEYSearch for more papers by this author, JOHN T. O'BRIANSearch for more papers by this author, LEON P. GEORGESSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-6-804_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCarpal tunnel syndrome is a common neuropathy that is either idiopathic or occurs in association with a wide variety of other disorders (1). We describe here what we believe is the first report of carpal tunnel syndrome occurring as a consequence of prolonged hypocalcemic carpopedal spasm in a patient with hypoparathyroidism.A 55-year-old right-handed white woman underwent total thyroidectomy and left radical neck dissection in 1962 for thyroid carcinoma with lymph node metastases. Postoperatively, she developed hypoparathyroidism and was placed on vitamin D and calcium. Her hypocalcemia nonetheless persisted, and she suffered intermittent episodes of tetany. She had recently presented...References1. CSEUZTHOMASLAMBERTLOVELIPSCOMB KJEJP: Longterm results of operation for carpal tunnel syndrome. Mayo Clin Proc 4:232-241, 1966 Google Scholar2. SIMPSON J: Electrical signs in the diagnosis of carpal tunnel and related syndromes. J Neurol Neurosurg Psychiatry 19:275-280, 1956 CrossrefMedlineGoogle Scholar3. STAAL A: The entrapment neuropathies, in The Handbook of Clinical Neurology, Vol. 7, edited by VINKEN PJ, BRUYN GW. Amsterdam, North-Holland Publishing Co., 1970, pp. 285-325 Google Scholar4. SUNDERLAND S: The nerve lesion in the carpal tunnel syndrome. J Neurol Neurosurg Psychiatry 39:615-626, 1976 CrossrefMedlineGoogle Scholar5. FRANKENHAEUSERHODGKIN BA: The action of calcium on the electrical properties of squid axons. J Physiol (Lond) 137:218-244, 1957 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNervus medianusCarpal tunnel syndrome: A reviewExperimental models 1 June 1978Volume 88, Issue 6Page: 804-805KeywordsCalciumHypocalcemiaHypoparathyroidismLymph nodesNeuropathyThyroid carcinomaThyroidectomyVitamin D Issue Published: 1 June 1978 Copyright© 1978 American College of PhysiciansPDF DownloadLoading ...
Interobserver reliability in the endoscopic diagnosis and grading of Barrett’s esophagus: an Asian multinational study
Authors: Y. Lee, M. Cook, S. Bhatia, W. Chow, E. El-Omar, H. Goto, J. Lin, Y. Li, P. Rhee, P. Sharma, J. Sung, J. Wong, J. Wu, K. Ho
Journal: Endoscopy (2010)

Background and study aim: The establishment of precise and valid diagnostic criteria is important for any disease. We determined the interobserver reliability in the endoscopic diagnosis and grading of Barrett's esophagus.
Environmental radiation: a cause for concern?
Authors: F. Godlee
Journal: BMJ (1992)

Put boldly, the NHS, involved in a common process-such as ordering Correspondence to:.*Dr D M Berwick, 131 Lake unlike much of American health care, is, or at least can and reporting laboratory test results, or controlling Avenue, Newton, be, a system, and because of that it has great potential postoperative pain, or the registration of patients for Massachusetts 02159, USA.for rational planned action to meet the needs of those it hospital admission-would take the time to meet, to serves.But that systemic property also creates strong make their processes or work explicit through suchBMJf 1992;304:304-8 and ineluctable bonds among its components, no one techniques as flow diagrams, and to plan specific steps 304
The role of attachment in the development and prevention of sociopathy
Authors: Marinus H. Van IJzendoorn
Journal: Behavioral and Brain Sciences (1995)

Abstract Mealey's sociobiological model of sociopathy could profit from attachment theory, in particular, the theory and research on the basis of the Adult Attachment Interview (Main &amp; Goldwyn 1985–1993). Findings of an adult attachment study in a forensic psychiatric setting are summarized. Three attachment-oriented strategies for families, schools, and forensic settings are proposed to help reduce or prevent secondary sociopathy and criminal recidivism.
Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.
Authors: M Mehrabian, P Z Wen, J Fisler, R C Davis, A J Lusis
Journal: Journal of Clinical Investigation (1998)

We analyzed the inheritance of body fat, leptin levels, plasma lipoprotein levels, insulin levels, and related traits in an intercross between inbred mouse strains CAST/Ei and C57BL/6J. CAST/Ei mice are unusually lean, with only approximately 8% of body weight as fat, whereas C57BL/6J mice have approximately 18% body fat. Quantitative trait locus analysis using > 200 F2 mice revealed highly significant loci (lod scores > 4.3) on chromosomes 2 (three separate loci) and 9 that contribute to mouse fat-pad mass for mice on a high-fat diet. Some loci also influenced plasma lipoprotein levels and insulin levels either on chow or high-fat diets. Two loci for body fat and lipoprotein levels (on central and distal chromosome 2) coincided with a locus having strong effects on hepatic lipase activity, an activity associated with visceral obesity and lipoprotein levels in humans. A locus contributing to plasma leptin levels (lod score 5.3) but not obesity was identified on chromosome 4, near the leptin receptor gene. These data identify candidate regions and candidate genes for studies of human obesity and diabetes, and suggest obesity is highly complex in terms of the number of genetic factors involved. Finally, they support the existence of specific genetic interactions between body fat, insulin metabolism, and lipoprotein metabolism.
Clinical and Angiographic Implications of Coronary Stenting in Thrombus-Containing Lesions
Authors: Fernando Alfonso, Pedro Rodriguez, Paul Phillips, Javier Goicolea, Rosana Hernández, Maria-José Pérez-Vizcayno, Antonio Fernández-Ortiz, Javier Segovia, Camino Bañuelos, Paloma Aragoncillo, Carlos Macaya
Journal: Journal of the American College of Cardiology (1997)
A DIAGNOSTIC EXAMINATION OF ONE HUNDRED AND FIFTY CASES OF LEPROSY.
Authors: JONATHAN T. McDONALD
Journal: JAMA (1903)

Leprosy is a disease to which the average American physician gives but little thought or study; he is accustomed to regard it as a foreign malady, of interest to him only as a curiosity. This is a mistake; leprosy has existed for many years in various parts of the United States, but the only recognition it has thus far received has for the most part been by dermatologists in the centers of population. The ordinary general practitioner, "the backbone of the profession," and to whom this paper is presented, is the man on whom rests the responsibility of keeping in mind the general features of the disease, and the possibility of some day encountering a case when least expected, as it is essentially a constitutional disease as much as is tuberculosis, and comes as fairly within his own domain. With us in Hawaii the disease is on the decline; thus
Effect of isotretinoin on eccrine gland function
Authors: J.L. REES, N.H. COX
Journal: British Journal of Dermatology (1988)

Sweat secretion rate, stimulated by iontophoresis of pilocarpine, was measured before and during treatment with isotretinoin in 20 patients. Sweat secretion was increased during treatment in 15 patients (75%), but the mean increase of 15% was not statistically significant (P = 0.085, paired t-test; 95% confidence limits-0.2% to +30%) and no patients had a clinically apparent alteration of sweating. We conclude that there is no important change in stimulated sweating associated with isotretinoin therapy.
Hereditary angioedema: Molecular and clinical differences among European populations
Authors: Matthaios Speletas, Agnes Szilagyi, Fotis Psarros, Dimitru Moldovan, Markus Magerl, Maria Kompoti, Evangelia Gramoustianou, Andras Bors, Eniko Mihaly, Attila Tordai, Antigoni Avramouli, Lilian Varga, Marcus Maurer, Henriette Farkas, Anastasios E Germenis
Journal: Journal of Allergy and Clinical Immunology (2014)
Expression and release of the latent transforming growth factor ? binding protein by hepatocytes from rat liver
Authors: S Roth, J Schurek, A M Gressner
Journal: Hepatology (1997)

In very recent studies it was established that transforming growth factor beta (TGF-beta), likely to be the most relevant fibrogenic cytokine and regulator of cell proliferation, differentiation, and matrix metabolism, is expressed by hepatocytes (parenchymal cell [PC]) and secreted from cultured PC in a latent form incapable of receptor binding. The structural composition of the latent TGF-beta complex secreted by cultured PC is unknown. In some TGF-beta expressing cell types this cytokine is released as a large molecular weight complex containing in addition to the TGF-beta latency associated peptide (LAP) a disulfide bonded latent TGF-beta binding protein (LTBP), of which the existence and function in liver is hitherto unknown. This study is directed to the identification of LTBP expression in rat PC. Cells were isolated from rat liver with the collagenase method and analyzed for LTBP before and during culture under standard conditions using alkaline phosphatase anti-alkaline phosphatase (APAAP) immunostainings, metabolic labeling, messenger RNA (mRNA) detection (reverse-transcription polymerase chain reaction [RT-PCR]) and sequencing, and immunoblotting of gel chromatographically separated cell extracts and conditioned media, respectively. APAAP immunostainings applying a specific polyclonal LTBP-antiserum (ab 39) indicated expression of LTBP in PC of liver in situ and freshly isolated PC but a strong expression in cultured PC. Transcripts of LTBP-1 were detected by RT-PCR and confirmed by sequence analyses. Metabolic labeling of PC with [35S]-Met/Cys followed by immunoprecipitation of cell lysates with LTBP antiserum confirmed the synthesis of the high molecular mass complex of 250 kd containing LTBP with a molecular mass of 160 kd. Latent TGF-beta complexes, associated with LTBP related proteins, could be separated from both extracts and conditioned media of PC by gel filtration chromatography. They confirmed the release of the large latent TGF-beta complex from PC. Investigations of immunocytochemical LTBP staining under different culture conditions (TGF-beta supplementation, extracellular matrices) point to concordant variations of LTBP and TGF-beta expression. The results suggest a role for PC in paracrine- and autocrine-mediated effects of TGF-beta, which might be important for various cell activities in healthy and diseased liver.
TCT-82 Cost-effectiveness Of Transcatheter Left Atrial Appendage Occlusion Compared With 5 Alternative Anticoagulation Strategies For Stroke Prevention In Atrial Fibrillation: A Markov Decision Analysis
Authors: Bryan Yan, Chow Innes, Yat Yin Lam, Vivian Lee, Cheuk Man Yu
Journal: Journal of the American College of Cardiology (2012)
Antibiotic prophylaxis after percutaneous endoscopic gastrostomy
Authors: M. Kurien, D. S. Sanders
Journal: BMJ (2010)

Co-trimoxazole given through the tube after insertion shows promising results

Percutaneous endoscopic gastrostomy (PEG) was introduced into clinical practice in 1980.1 PEG is an effective way of providing enteral feeding to patients who have functionally normal gastrointestinal tracts but who cannot meet their nutritional needs because of inadequate oral intake.1 PEG insertion rates are rising—more than 15 000 procedures are undertaken in the United Kingdom each year, and rates are similar internationally.2 3

After PEG insertion, 30 day mortality and complication rates are high.4 The most common complication is wound (insertion site) infection, with reported rates varying from 4% to 30%.5 Patients are often susceptible to infection because of their reduced nutritional status, advanced age, and underlying disease.6 7 To avoid wound infection and the potential associated morbidity and mortality, conventional practice is to use prophylactic systemic antibiotics. International guidelines recommend the use of intravenous co-amoxiclav or a second or third generation cephalosporin before gastrostomy insertion.7 8 This is based on reduced …
MPs push for ban on smoking in cars with children
Authors: A. Gulland
Journal: BMJ (2011)

MPs have added their voices to a growing movement to ban adults smoking in cars with children in them.

The Labour MP Alex Cunningham’s 10 minute rule bill urging ministers to implement a ban on smoking in cars won the backing of 77 other MPs and is due to be debated for a second time in November.

Mr Cunningham’s Stockton North constituency is 15th in the British Lung Foundation’s ranking of areas where children are most likely to be exposed to cigarette smoke.

Speaking in the House of Commons he said, “The science is clear. Experts say that children are particularly vulnerable to passive smoke, as they …
Abstract 2932: Knockdown of polypyrimidine tract-binding protein (PTB) sensitizes ovarian cancer cells to chemotherapeutic agents <i>in vitro</i>
Authors: Ahmet D. Arslan, Matthew Maggio, Lamiaa El-Shennawy, Xiaolong He, William T. Beck
Journal: Cancer Research (2012)

Abstract While chemotherapy is the second-line of therapy for the treatment of epithelial ovarian cancer (EOC) after surgery, drug resistance constitutes a significant obstacle to achieving a complete response in many patients. There is a clear unmet need for new treatments for EOC patients. We have shown that PTB is frequently overexpressed and associated with malignancy in EOC (He et al, Clin Cancer Res, 10:4652-60, 2004, He et al, Oncogene 30:356-65, 2011). PTB knockdown via RNA interference significantly impairs EOC cell growth in vitro and in vivo, as well as invasiveness and colony formation in soft agar in vitro (He et al, Oncogene 26:4961-8, 2007). PTB or hnRNP-I is a splicing factor that regulates alternative pre-mRNA splicing, and has been implicated in metabolic, cytoskeletal, and cell membrane changes in cancer cells. In this study, we used A2780 cell lines carrying doxycycline (doxy)-inducible PTB shRNA. We characterized stable transfectants of A2780 cells that carry shRNA against PTB and cells carry a non-targeting control shRNA. In a 48 h MTT cytotoxicity assay, knockdown of PTB inhibited cell growth. When cells with PTB knockdown were treated with carboplatin or paclitaxel, drugs used as current standard of care in EOC, we observed 3- to 6-fold increases in drug sensitivity compared to the vector control. To rule out any drug-drug interaction (e.g., doxy-paclitaxel) (Foroodi et al, Anticancer Drugs 2009 20:115-22) in our assay, we evaluated the kinetics of the inducible knockdown system by western blot. We found that a 120 h doxy treatment was optimal to insure full depletion of PTB, and after doxy removal PTB suppression lasted 48 h more before recovering to its basal level. Based on those data, we performed all the cytotoxicity experiments within 48 h without exposing cells to both doxy and drug at once, and thereby avoiding drug-drug interactions. Findings here support the idea that PTB and other splicing factors may be novel drug targets in the treatment of ovarian cancer. (Support in part by NCI grants R01 CA40570 and R01 CA138762 [to WTB], by OCRF [to XH], and by UIC.) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2932. doi:1538-7445.AM2012-2932
Clinical Use of Antibodies to Intrinsic Factor.
Authors: Sheldon P. Rothenberg
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Clinical Use of Antibodies to Intrinsic Factor.Sheldon P. Rothenberg, M.D., F.A.C.P., Rajani Kantha, M.D.Sheldon P. Rothenberg, M.D., F.A.C.P.Search for more papers by this author, Rajani Kantha, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-795_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough the identification of antibodies (AB) against intrinsic factor in serum of some pernicious anemia (PA) patients has raised questions about pathogenesis of this disease, of more practical clinical value has been the use of such AB as an aid to rapid etiologic diagnosis of megaloblastic anemias. Two types of AB have been defined; one blocks intrinsic factor from binding B12, and a second binds intrinsic factor or intrinsic factor-B12. Identification of AB in serum supports with 99% certainty diagnosis of PA. A newly developed radioassay for AB using low substrate concentrations is more sensitive, rapid, and easily adapted to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Sheldon P. Rothenberg, M.D., F.A.C.P.; Rajani Kantha, M.D.Affiliations: New York, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 795-796KeywordsAntibodiesAttentionMegaloblastic anemiaPathogenesisPernicious anemia ePublished: 1 December 2008 Issue Published: 1 May 1970 PDF downloadLoading ...
Blood sugar and beta-blockers.
Authors: S P Linton, P H Scott, M J Kendall
Journal: BMJ (1976)

me is to produce a non-encephalitogenic and attenuated but still efficacious and immunogenic vaccine for use in the final stages of the WHO smallpox eradication campaign and for a safety period of 2-3 years thereafter, assuming that in this interim period no smallpox variant is detected anywhere in wildlife.'
Prevention of recurrence of esophageal varices after endoscopic injection sclerotherapy with ethanolamine oleate
Authors: Seigo Kitano, Nobuhiro Koyanagi, Yasunori Iso, Hidefumi Higashi, Keizo Sugimachi
Journal: Hepatology (1987)

Endoscopic injection sclerotherapy was given to 155 patients with esophageal varices mainly related to non-alcoholic liver cirrhosis. The formation of a superficial ulcer in the lower esophagus was achieved in 141 (91.0%) of the 155 patients, with an average of 4.1 sessions of endoscopic injection sclerotherapy during an average time of 4.9 weeks. The average volume of 5% ethanolamine oleate sclerosant used was 24.8, 19.2, 12.3 and 6.5 ml for the initial to fourth sessions of endoscopic injection sclerotherapy, respectively. For 14 patients, a sufficient number of sessions of endoscopic injection sclerotherapy could not be given: 10 early deaths (5 hepatoma, 4 liver failure and 1 gastric bleeding), and 4 refused further sessions. When the esophageal mucosa had been eliminated and a superficial ulcer had formed, episodes of recurrent bleeding or recurrence of esophageal varices were nil over a median follow-up of 14.6 months, with a range of 1 to 27 months. In seven patients, bleeding recurred before elimination of the mucosa could be achieved, but these bleeding episodes were well controlled with an additional session of endoscopic injection sclerotherapy. At the time of analysis, there were 36 deaths (20 hepatoma, 14 liver failure and 2 gastric bleeding) among these 155 patients. Thus, the mean follow-up was 16.3 months (range: 7 to 27 months) in the 119 survivors, with no recurrence of the varices. We propose that removal of the esophageal mucosa may well be the endpoint of repeated endoscopic injection sclerotherapy in the management of patients on injection sclerotherapy.