The Diagnostic Significance of the Parietal Cell Immunofluorescent Test
Authors: H. BERNHARDT
Journal: Annals of Internal Medicine (1965)

Article1 October 1965The Diagnostic Significance of the Parietal Cell Immunofluorescent TestH. BERNHARDT, M.D., L. L. BURKETT, M.D., M. L. FIELDS, M.D., J. KILLIANH. BERNHARDT, M.D.Search for more papers by this author, L. L. BURKETT, M.D.Search for more papers by this author, M. L. FIELDS, M.D.Search for more papers by this author, J. KILLIANSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-4-635 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe subject of auto-antibodies in pernicious anemia and the auto-immune nature of this disease is presented lucidly in recent publications by Doniach and Roitt (1) and Irvine (2). Serological tests have revealed two distinct antibodies in pernicious anemia, one reactive with intrinsic factor (3, 4) and the other against saline extracts of gastric homogenates (5). The mitochondrial-microsomal fraction of gastric fundal mucosa was found to be a better antigen than the crude saline extracts (6).While attempts to demonstrate intrinsic factor antibodies by immunofluorescence have been unsuccessful, antibodies to gastric parietal cells have been readily shown in a high percentage...References1. DONIACHROITT DIM: An evaluation of gastric and thyroid auto-immunity in relation to hematologic disorders. Seminars Hemat. 1: 313, 1964. MedlineGoogle Scholar2. IRVINE WJ: Gastric antibodies studied by fluorescence microscopy. Quart. J. Exp. Physiol. 48: 427, 1963. CrossrefMedlineGoogle Scholar3. SCHWARTZ M: Intrinsic factor antibody in serum from patients with pernicious anemia. Lancet 2: 1263, 1960. CrossrefMedlineGoogle Scholar4. TAYLOR KB: Inhibition of intrinsic factor by pernicious anaemia sera. Lancet 2: 106, 1959. CrossrefMedlineGoogle Scholar5. IRVINEDAVIESDELAMOREWILLIAMS WJSHIWAW: Immunological relationship between pernicious anaemia and thyroid disease. Brit. Med. J. 2: 454, 1962. CrossrefGoogle Scholar6. TAYLORROITTDONIACHCOUCHMANSHAPLAND KBIMDKGC: Autoimmune phenomena in pernicious anaemia: gastric antibodies. Brit. Med. J. 2: 1347, 1962. CrossrefMedlineGoogle Scholar7. ADAMSGLENKENNEDYMACKENZIEMORROWANDERSONGRAYMIDDLETON JFAIEHILJMJRKGDC: The histological and secretory changes in the stomach in patients with autoimmunity to gastric parietal cells. Lancet 1: 401, 1964. CrossrefMedlineGoogle Scholar8. FISHERTAYLOR JMKB: A comparison of autoimmune phenomena in pernicious anemia and chronic atrophic gastritis. New Eng. J. Med. 272: 499, 1965. CrossrefMedlineGoogle Scholar9. TEVELDEABELSANDERSARENDSHOEDEMAEKERNIEWEG KJGJAPJHO: A family study of pernicious anemia by an immunologic method. J. Lab. Clin. Med. 64: 177, 1964. MedlineGoogle Scholar10. WOLFPEARSONROSENBLATTVAZQUEZJARKOWSKI PLBMJT: A rapid method to diminish nonspecific reactions in immunofluorescence, with the use of tagged 7S gamma-globulin immune serums. Amer. J. Clin. Path. 43: 47, 1965. CrossrefMedlineGoogle Scholar11. SZULMAN AE: The histological distribution of blood group substances A and B in man J. Exp. Med. III: 785, 1960. CrossrefGoogle Scholar12. TEVELDEABELSHOEDEMAEKERARENDSNIEWEG KJPJAHO: Histological and secretory changes in the stomach of patients with autoimmunity to gastric parietal cells. Lancet 1: 941, 1964. MedlineGoogle Scholar13. MOORENEILSON JMJM: Antibodies to gastric mucosa and thyroid in diabetes mellitus. Lancet 2: 645, 1963. CrossrefMedlineGoogle Scholar14. HERBERT V: Current concepts in therapy. Megaloblastic anemia. New Eng. J. Med. 268: 368, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: H. BERNHARDT, M.D.; L. L. BURKETT, M.D.; M. L. FIELDS, M.D.; J. KILLIANAffiliations: Memphis, TennesseeFrom the Laboratory Service, the Hematology Section of the Medical Service, and the Radioisotope Service, Veterans Administration Hospital, and the University of Tennessee, College of Medicine, Memphis, Tenn.Requests for reprints should be addressed to Luther L. Burkett, M.D., Medical Service, Veterans Administration Hospital, Park Ave. and Getwell St., Memphis, Tenn. 38115. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byParietal Cell Antibodies among Peruvians with Gastric Pathologic ChangesAn appraisal of tests for severe atrophic gastritis in relatives of patients with pernicious anemiaVariable heavy chain (VH) subgroups of human autoantibody moleculesThe association of atrophic gastritis with autoimmune thyroid diseaseParietal cell antibodies part I. 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JEFFRIES, M.B., M.R.C.P. 1 October 1965Volume 63, Issue 4Page: 635-641KeywordsAnemiaAntibodiesGastritisHospital medicineMucous membranesNutritionParietal cellsPernicious anemiaResearch laboratoriesThyroid ePublished: 1 December 2008 Issue Published: 1 October 1965 PDF downloadLoading ...