Markers of Mineral Metabolism and Cardiovascular Disease
Authors: Brendan M. Everett
Journal: Annals of Internal Medicine (2010)

Editorials18 May 2010Markers of Mineral Metabolism and Cardiovascular DiseaseBrendan M. Everett, MD, MPHBrendan M. Everett, MD, MPHFrom Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-10-201005180-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Recent scientific interest has focused on abnormalities in mineral metabolism and the role those abnormalities may play in the pathogenesis of cardiovascular disease (CVD). Many vascular biologists believe that arterial calcification, rather than a passive product of aging, is an active process mediated by signaling molecules, such as osteocalcin, osteopontin, bone morphogenic protein, matrix Gla protein, and fibroblast growth factor, among others (1). These signals are induced by inflammatory and lipid mediators that have established roles in atherothrombosis, including transforming growth factor-β and oxidized low-density lipoprotein cholesterol, and lead to transformation of vascular smooth-muscle cells into osteoblast-type cells (2, 3). ...References1. Demer LL. A skeleton in the atherosclerosis closet [Editorial]. Circulation. 1995;92:2029-32. [PMID: 7554176] CrossrefMedlineGoogle Scholar2. Watson KE, Boström K, Ravindranath R, Lam T, Norton B, Demer LL. TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify. J Clin Invest. 1994;93:2106-13. [PMID: 8182141] CrossrefMedlineGoogle Scholar3. Mody N, Parhami F, Sarafian TA, Demer LL. Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic Biol Med. 2001;31:509-19. [PMID: 11498284] CrossrefMedlineGoogle Scholar4. Dhingra R, Sullivan LM, Fox CS, Wang TJ, D'Agostino RB, Gaziano JM, et al. Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med. 2007;167:879-85. [PMID: 17502528] CrossrefMedlineGoogle Scholar5. Foley RN, Collins AJ, Ishani A, Kalra PA. Calcium-phosphate levels and cardiovascular disease in community-dwelling adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J. 2008;156:556-63. [PMID: 18760141] CrossrefMedlineGoogle Scholar6. Hagström E, Hellman P, Larsson TE, Ingelsson E, Berglund L, Sundström J, et al. Plasma parathyroid hormone and the risk of cardiovascular mortality in the community. Circulation. 2009;119:2765-71. [PMID: 19451355] CrossrefMedlineGoogle Scholar7. Marniemi J, Alanen E, Impivaara O, Seppänen R, Hakala P, Rajala T, et al. Dietary and serum vitamins and minerals as predictors of myocardial infarction and stroke in elderly subjects. Nutr Metab Cardiovasc Dis. 2005;15:188-97. [PMID: 15955467] CrossrefMedlineGoogle Scholar8. Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med. 2008;168:1174-80. [PMID: 18541825] CrossrefMedlineGoogle Scholar9. Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008;117:503-11. [PMID: 18180395] CrossrefMedlineGoogle Scholar10. Dobnig H, Pilz S, Scharnagl H, Renner W, Seelhorst U, Wellnitz B, et al. Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch Intern Med. 2008;168:1340-9. [PMID: 18574092] CrossrefMedlineGoogle Scholar11. Parker BD, Schurgers LJ, Brandenburg VM, Christenson RH, Vermeer C, Ketteler M, et al. The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study. Ann Intern Med. 2010;152:640-8. LinkGoogle Scholar12. Gutiérrez OM, Januzzi JL, Isakova T, Laliberte K, Smith K, Collerone G, et al. Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease. Circulation. 2009;119:2545-52. [PMID: 19414634] CrossrefMedlineGoogle Scholar13. Cranenburg EC, Brandenburg VM, Vermeer C, Stenger M, Mühlenbruch G, Mahnken AH, et al. Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients. Thromb Haemost. 2009;101:359-66. [PMID: 19190822] CrossrefMedlineGoogle Scholar14. Ix JH, Chertow GM, Shlipak MG, Brandenburg VM, Ketteler M, Whooley MA. Association of fetuin-A with mitral annular calcification and aortic stenosis among persons with coronary heart disease: data from the Heart and Soul Study. Circulation. 2007;115:2533-9. [PMID: 17485576] CrossrefMedlineGoogle Scholar15. Ix JH, Shlipak MG, Sarnak MJ, Beck GJ, Greene T, Wang X, et al. Fetuin-A is not associated with mortality in chronic kidney disease. Kidney Int. 2007;72:1394-9. [PMID: 17882149] CrossrefMedlineGoogle Scholar16. Hermans MM, Brandenburg V, Ketteler M, Kooman JP, van der Sande FM, Boeschoten EW, et al. Netherlands cooperative study on the adequacy of Dialysis (NECOSAD). Association of serum fetuin-A levels with mortality in dialysis patients. Kidney Int. 2007;72:202-7. [PMID: 17342178] CrossrefMedlineGoogle Scholar17. Gutiérrez OM, Mannstadt M, Isakova T, Rauh-Hain JA, Tamez H, Shah A, et al. Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N Engl J Med. 2008;359:584-92. [PMID: 18687639] CrossrefMedlineGoogle Scholar18. Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest. 2002;110:229-38. [PMID: 12122115] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M10-0740.Corresponding Author: Brendan M. Everett, MD, MPH, 900 Commonwealth Avenue, Boston, MA 02215; e-mail, [email protected]org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Associations of Fibroblast Growth Factor 23 and Uncarboxylated Matrix Gla Protein With Mortality in Coronary Artery Disease: The Heart and Soul Study Benjamin D. Parker , Leon J. Schurgers , Vincent M. Brandenburg , Robert H. Christenson , Cees Vermeer , Markus Ketteler , Michael G. Shlipak , Mary A. Whooley , and Joachim H. Ix Metrics 18 May 2010Volume 152, Issue 10Page: 683-684KeywordsCalciumCardiovascular diseasesHazard ratioHeart failureLipidsMortalityOsteocalcinPhosphorusRisk managementVitamin D ePublished: 18 May 2010 Issue Published: 18 May 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...