tbuckley/cabot-search huggingface dataset:
Abstract 1485: The role of angiopoietin family members in the progression of ovarian cancer
Authors: Melissa K. Brunckhorst, Qin Yu
Journal: Cancer Research (2012)

Abstract Despite advances in surgical debulking, radiation, and chemotherapy over the past few decades, ovarian carcinoma remains the most deadly gynecological malignancy. This is largely due to the lack of early stage detection manifesting in approximately 80% of patients presenting with metastatic disease at the time of diagnosis. Current chemotherapeutic drugs are effective only for a short period as patients with advance disease eventually develop resistance despite significant initial responses. Thus, there is a pressing need for the identification of novel therapeutic targets in ovarian cancer. Mounting evidence suggests that the Angiopoietin/Tie-2 functional axis has wide-ranging effects on tumor angiogenesis and progression of a variety of cancer types, however, the expression profiles and biological effects of the Angiopoietin family members on ovarian cancer remain largely unknown. Our data show for the first time that Ang-1, Ang-2 and Ang-4 are expressed in ovarian cancer cell lines and patient samples from both primary and secondary tumor lesions. More specifically, patient tumors revealed a unique localization pattern of Angiopoietin family members whereby Ang-1 and Ang-2 are robustly expressed in tumor cells and stroma, whereas Ang-4 expression is predominately in the tumor stroma. In addition, we show that overexpression of Ang-4 and Ang-2 and, to a lesser extent, Ang-1, promotes subcutaneous growth of ovarian cancer cells and results in accelerated ascites formation and poor survival in an orthotopic ovarian cancer mouse model. Immunohistochemical analysis of orthotopic tumors suggests the pro-growth effects of Ang-1 and Ang-4 are mediated through increased tumor cell proliferation as determined by positive Ki67 staining. Our results also demonstrated that ovarian cancer cells express Tie-2 receptor tyrosine kinase (RTK), the angiopoietin receptor. The expression of Tie-2, as well as angiopoietin family members, by ovarian cancer cells suggests the potential of an Angiopoietin/Tie-2 autocrine loop. Lastly, further analysis suggests the potential role of angiopoietins in increasing the amount of cancer associated fibroblasts (CAFs) in the tumor microenvironment. Taken together, our data suggest that the Angiopoietin/Tie-2 functional axis is a significant player in ovarian cancer progression and is a potential target for ovarian cancer therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1485. doi:1538-7445.AM2012-1485
Drugs in Pregnancy
Authors: Virginia Apgar
Journal: JAMA (1964)

SINCE the thalidomide tragedy of 1960 to 1962, pregnant women have been in a quandary about taking common medications on their own initiative, and physicians have been troubled about prescribing drugs for them. Peckham and King<sup>1</sup>have shown recently that 92% of women have at least one drug prescribed by their physicians during pregnancy, and 3.9% are given ten or more. There is no count of babies who have survived because of drugs administered during pregnancy, infants who escaped birth defects because their mothers were given certain drugs, or full-term babies who might have been born prematurely without drugs. Both physicians and patients rightly demand to know what information is available about drugs and human pregnancy. Very little is known that can actually be applied to all pregnancies. According to Lenz,<sup>2</sup>80% of the mothers who took thalidomide during the period of fetal sensitivity had normal infants. What
Rheumatic Fever and the Blood Groups
Authors: J. A. Buckwalter, G. S. Naifeh, J. E. Auer, J. H. Edwards
Journal: BMJ (1962)

DIAISHNAL 1023 on safari.Finally, so many medical officers, specialists, and administrators in every country visited gave unstinting assistance and co-operation that mention of any names would be invidious.To one and all I offer my sincere thanks.
Treatment of Alcoholism
Authors: Charles R. Queen
Journal: JAMA (1977)

<h3>To the Editor.—</h3> It was with a great deal of interest that I read Dr Eric Fine's letter (236:1235, 1976) in which he champions the cause of tailored treatment (total abstinence vs responsible drinking) for alcohol abusers. Having left a 17-year, small-town general practice for the Air Force, my practice suddenly has become one dealing with young people whose lifestyle and problems are substantially different. As part of my duties, I have had the opportunity to sit in on weekly committee meetings on alcohol abuse. I also personally interview each person who has had an alcoholrelated incident or who has been identified by other means. To justify the statements I am about to make would take much more space than a letter allows; thus, the reader will have to be understanding. Our plan here in Germany is to take the young alcohol abuser and expose him to an eight-hour awareness
Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta
Authors: Yoichi Sekita, Hirotaka Wagatsuma, Kenji Nakamura, Ryuichi Ono, Masayo Kagami, Noriko Wakisaka, Toshiaki Hino, Rika Suzuki-Migishima, Takashi Kohda, Atsuo Ogura, Tsutomu Ogata, Minesuke Yokoyama, Tomoko Kaneko-Ishino, Fumitoshi Ishino
Journal: Nature Genetics (2008)
Problems in Differentiating SLE and Mixed Connective-Tissue Disease
Authors: Morris Reichlin
Journal: New England Journal of Medicine (1976)

Although the nature of systemic lupus erythematosus still poses many mysteries, substantial progress has been made in defining specific autoantigens reactive with the serum of patients with this disease.1 Foremost among the antinuclear antibodies, the presence of antibodies to native DNA correlates, with rare exception, with the clinical diagnosis. These antibodies to DNA are of more than diagnostic interest since the cumulative evidence is strong that the DNA-anti-DNA system is the major immune system implicated in the pathogenesis of lupus nephritis in an immunecomplex mechanism. Clearly, identification of the DNA-anti-DNA system has led to a more incisive understanding of immunopathogenetic . . .
Of Ears and E-mails
Authors: John H. Stone
Journal: Annals of Internal Medicine (2004)

On Being a Doctor3 August 2004Of Ears and E-mailsJohn H. Stone, MD, MPHJohn H. Stone, MD, MPHFrom Johns Hopkins University School of Medicine, Baltimore, MD 21224.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-3-200408030-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The news came via e-mail: “Well, the day has come. Last week, while visiting my friend Andie in Cincinnati, my right ear started to change and slowly my hearing aid has become useless. I am now profoundly deaf. … I'm O.K. with that—as much as one can be; I've had 4 years to prepare.” With that Internet message to me and my otolaryngology colleague, Dr. Francis, Stacey informed us that our efforts to preserve her hearing had failed. During the time I had been her doctor, I had admired much in Stacey. Feeling utterly powerless in the wake of her ... Author, Article, and Disclosure InformationAffiliations: From Johns Hopkins University School of Medicine, Baltimore, MD 21224.Current Author Address: John H. Stone, MD, MPH, The Johns Hopkins Vasculitis Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 August 2004Volume 141, Issue 3Page: 241-242KeywordsCyclophosphamideDeafnessEmotionsFoodHearingInternetNecrosisSteroidsVasculitisVertigo ePublished: 3 August 2004 Issue Published: 3 August 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Papular mucinosis associated with generalized morphoea
Authors: F. Rongioletti, P. Rampini, A. Parodi, A. Rebora
Journal: British Journal of Dermatology (1999)

A 67-year-old white man is described who had large sclerotic plaques with a violaceous border on his back and abdomen and a scleroderma-like induration on the legs, sparing the feet. Additionally, he had multiple skin-coloured, large, sometimes centrally depressed papules and nodules on the nape of the neck, back and upper limbs. These occurred in both the normal and sclerotic areas. Histologically, large amounts of focal mucin were seen in the upper dermis consistent with the diagnosis of papular mucinosis and associated with typical underlying features of scleroderma. No paraproteinaemia was found. We excluded scleromyxoedema on clinical, histopathological and laboratory grounds and diagnosed our patient as having generalized morphoea with papular mucinosis. We are aware of only two reports of large cutaneous deposits of mucin associated with scleroderma.
<i>In vivo</i> relevance of CD30 in atopic dermatitis
Authors: M. Caproni, B. Bianchi, M. M. D'Elios, M. De Carli, A. Amedei, P. Fabbri
Journal: Allergy (1997)

CD30 expression was evaluated by immunohistochemistry in lesional skin biopsies of eight patients with active atopic dermatitis (AD) and three patients with allergic contact (nickel‐induced) dermatitis (ACD). CD30 expression was also assessed in a large panel of CD4 + and CDS + T‐cell clones generated from the skin biopsies of four patients with AD. Finally, the levels of soluble CD30 (sCD30) were measured in the serum of 41 patients with AD, 19 patients with ACD, and 60 healthy controls. In all specimens of lesional AD skin, where the great majority of infiltrating cells were CD4+ T cells, remarkable numbers of cells were CD30+, whereas virtually no CD30 + cells were found in the skin of patients with ACD. In CD4+ T‐cell clones generated from the lesional AD skin, most of which produced both interleukin (IL)‐4 and interferon‐gamma (IFN‐γ) (Th0–like cells) or IL‐4 and 1L‐5, but not IFN‐γ (Th2–like cells), CD30 expression directly correlated with the ability to produce IL‐4 and IL‐5, but was inversely related to IFN‐γ production. High levels of sCD30 (correlated with disease activity: r = 0.618) were detected in the serum of most AD patients, whereas there was no increase of sCD30 levels in the serum of patients with ACD. These data support the view that Th0/Th2–type responses predominate in the skin of patients with AD and suggest that the presence of CD30 + T cells in tissues and/or increased levels of sCD30 in biologic fluids are indicative of Th2–dominated responses.
Reinterpreting behavior: A human specialization?
Authors: Daniel J. Povinelli, Jochen Barth
Journal: Behavioral and Brain Sciences (2005)

Tomasello et al. argue that the “small difference that made a big difference” in the evolution of the human mind was the disposition to share intentions. Chimpanzees are said to understand certain mental states (like intentions), but not share them. We argue that an alternative model is better supported by the data: the capacity to represent mental states (and other unobservable phenomena) is a human specialization that co-evolved with natural language.
Epigallocatechin gallate prevents cell proliferation of hepatic stellate cells due to blockade of PDGF binding to its receptor in a non-competitive manner
Authors: Ryuichiro Sakata, Takato Ueno, Toru Nakamura, Osamu Hashimoto, Riko Harada, Masaharu Sakamoto, Takuji Torimura, Michio Sata
Journal: Journal of Hepatology (2002)
Change in Prevalence of Chronic Conditions Between Childhood and Adolescence Among Extremely Low-Birth-Weight Children
Authors: Maureen Hack, Mark Schluchter, Laura Andreias, Seunghee Margevicius, H. Gerry Taylor, Dennis Drotar, Leona Cuttler
Journal: JAMA (2011)

Extremely low-birth-weight (ELBW) children have high rates of chronic conditions during childhood. Information on their trajectory of health during adolescence is needed for health care planning.
Status of a National Disaster Medical Response
Authors: Paul B. Roth
Journal: JAMA (1991)

DISASTER MEDICINE is in its infancy in the United States. Aside from the periodic reminder to update our disaster plans for the Joint Commission on Accreditation of Healthcare Organizations and conduct a couple of drills each year, no one tends to think about the exceptionally remote possibility of a catastrophic event—although it will surely occur. In the midst of this overwhelming indifference, three events occurred during the last decade that served to heighten our sensibilities to disaster preparedness. In 1980, Mount St Helens blew its top, accelerating a series of federal activities that were already initiated, culminating in the creation of the National Disaster Medical System (NDMS)—a purely voluntary system with no allocated budget. In 1989, Hurricane Hugo and the Loma Prieta earthquake occurred only months apart and tested the NDMS and the Federal Emergency Management Agency. These disasters demonstrated a number of weaknesses in both
Nitric Oxide and Vascular Disease
Authors: Joseph Loscalzo
Journal: New England Journal of Medicine (1995)

Nitric oxide is as simple chemical substance whose many biologic roles have only recently been appreciated. First discovered by Furchgott and Zawadzki as an endothelium-dependent vasodilating substance (endothelium-derived relaxing factor) in the vasculature,1 this product of the normal endothelial cell is an important regulator of vascular tone. The identification of endothelium-derived relaxing factor as nitric oxide was independently established in 1987 by Ignarro and colleagues2 and Palmer and coworkers.3 Although nitric oxide is a structurally simple heterodiatomic molecule, it has an array of complex biochemical actions that evoke a wide range of biologic effects.4 Nitric oxide is synthesized by the . . .
1044-54 Influence of vessel wall calcium on neointimal growth following bare metal and sirolimus-eluting stent implantation: A 3-D intravascular ultrasound substudy of the SIRIUS trial
Authors: Yoshihisa Shimada, Junya Ako, Brian K Courtney, Toru Kataoka, Shinjo Sonoda, Yoshihiro Morino, Jeffrey W Moses, Martin B Leon, Peter J Fitzgerald, Paul G Yock, Yasuhiro Honda
Journal: Journal of the American College of Cardiology (2004)
Elimination of maternally transmitted autoantibodies prevents diabetes in nonobese diabetic mice
Authors: Siri Atma W. Greeley, Makoto Katsumata, Liping Yu, George S. Eisenbarth, Daniel J. Moore, Heidi Goodarzi, Clyde F. Barker, Ali Naji, Hooman Noorchashm
Journal: Nature Medicine (2002)
The Usefulness of the RPR
Authors: Stephen D. Boren
Journal: JAMA (1985)

<h3>To the Editor.—</h3> I enjoyed reading "The Usefulness of Preoperative Laboratory Screening."1 However, the authors fail to address the usefulness of one of their standard laboratory tests—the rapid plasma reagent (RPR) test. Since their medical center has approximately 8,600 elective surgical admissions per year and each includes an RPR, this cost (at $13.50 per test) is $116,100 annually. The value of routine serological tests either as an admission requirement to hospitals<sup>2,3</sup>or for premarital examination by law<sup>4</sup>has been debated. Its value in preventing congenital syphilis is not in question. San Francisco does have the highest civilian reported rate of primary and secondary syphilis in the United States.<sup>5</sup>However, what percentage is from hospital screening vs venereal disease clinics, blood bank screening, or premarital screening is unknown to me. Except for a positive serological test result being a relative contraindication to spinal anesthesia, it is unlikely that
Liver Injury Due to Quinidine
Authors: Joseph E. Herman
Journal: JAMA (1975)

THE SALIENT features of quinidine-induced liver injury that have come to light from earlier reports are fever; a mixed typeof hepatic injury; a rapid return of the enzyme tests to normal on withdrawal of quinidine; and a shortening of the latency period on reexposure to the drug, with fever and disordered liver function appearing sooner and after progressively smaller doses.<sup>1-3</sup>The features are similar to those caused by other hepatotoxic agents leading to a hypersensitivity type of liver injury.<sup>4-5</sup>We are describing a patient whose clinical course after quinidine ingestion showed all of the above features and who, in addition, evidenced prolonged hepatocellular damage on testing with sulfobromophthalein sodium (Bromsulphalein). <h3>Report of a Case</h3> A 65-year-old man, married and the father of two, was admitted to the Central Emek Hospital Afula, Israel, because of fever of two weeks' duration. Prior to the onset of his illness, the patient
Re: Robert B. Nadler. Words of Wisdom re: A Randomized Comparison of Totally Tubeless and Standard Percutaneous Nephrolithotomy in Elderly Patients. Kara C, Resorlu B, Bayindir M, Unsal A. Urology 2010;76:289–93. Eur Urol 2011;59:1070
Authors: Cengiz Kara
Journal: European Urology (2011)
Fertility regulator tells clinics to treat egg and sperm donors better to boost numbers
Authors: I. Torjesen
Journal: BMJ (2012)

The Human Fertilisation and Embryology Authority (HFEA) has launched a national strategy to boost the number of egg and sperm donors by raising awareness about donating and improving the way that donors are treated by clinics.

The authority is establishing an expert group to look at ways of raising awareness of donation, to debate contentious issues and to ameliorate areas of concern, and to promote good practice among clinics to ensure that potential donors feel supported and not discouraged.

The strategy was announced as new rules governing how much egg donors can be paid in compensation came into force. …
TYPHOID FEVER IN A LEPER, FOLLOWING IMMEDIATELY BUT ACCIDENTALLY ON TREATMENT WITH ANTIVENOMOUS SERUM.
Authors: J. F. SCHAMBERG
Journal: JAMA (1900)

The following report is deemed worthy of presentation because of several unique features connected therewith. Whilst there is no reason why lepers should not, if exposed, contract typhoid fever, there seems to be, as far as I have been able to ascertain, no recorded instance of the simultaneous existence of these diseases. Furthermore, several eminent leprologists, to whom an inquiry as to the incidence of typhoid fever among lepers was addressed, have replied that they have never noted its occurrence. A letter received from Dr. G. Armauer Hansen, Bergen, Norway, says: "Since 1868 we have not had typhoid fever here, and consequently I am unable to give you any information on this question. I have seen an epidemic of measles and this malady run the same course amongst the lepers as among others." The fever in the present case developed after the use of injections of antivenomous serum. In 1897,
Risks of dependence on benzodiazepine drugs
Authors: S. I Cohen
Journal: BMJ (1989)

authority populations as being crucial to success.To ensure that the new health service works for populations as well as for individual patients a director of public health must be an executive member of every new health authority, alongside the general manager and the finance director.Otherwise, directors of public health and health authorities will be unable to fulfil all the requirements of HC(88)64 and the white paper.
Induction of Ca2+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2–IP3 receptor interaction
Authors: Fei Zhong, Michael W. Harr, Geert Bultynck, Giovanni Monaco, Jan B. Parys, Humbert De Smedt, Yi-Ping Rong, Jason K. Molitoris, Minh Lam, Christopher Ryder, Shigemi Matsuyama, Clark W. Distelhorst
Journal: Blood (2010)
Sun protection factors: world wide confusion
Authors: U. Osterwalder, B. Herzog
Journal: British Journal of Dermatology (2009)

The Sun Protection Factor (SPF) is a very popular instrument in the marketing of sunscreens. Unfortunately it is often not understood how sunscreens work and where the limitations of the SPF are. A lot of aspects of the SPF are confusing, e.g. the race for higher and higher numbers, the effect on SPF when less sunscreen is applied and if sunscreen should be used at all because they may block the Vitamin D synthesis. All this has a negative impact on compliance by the consumer or patient which is the most important influence factor in sun protection. This paper explains how sunscreens work, how the SPF is determined and where the limitations of the current methods exist. The dynamic view of 'UV radiation applied' and the 'UV dose transmitted' through the sunscreen onto the skin as well as onto a substrate in vitro help in the understanding and are also promising approaches in the in vitro assessment. A variation of the in vitro assessment of a sunscreen is the in silico calculation based on the absorption spectrum of the UV filters and an assumption about the irregular sunscreen film on the skin. The sunscreen simulator program can be used to determine how the SPF is affected by applying smaller amounts of sunscreen. Besides the SPF, UVA protection is also discussed. The degree of UVA protection determines the quality of the overall UV protection, whereas the SPF is an indication of the quantity of protection. Furthermore other protection factors such as IPF, iSPF, RSF and p53, and the inhibition of the Vitamin D3 synthesis by sunscreens are also discussed. In conclusion it is shown that the accuracy and robustness of the SPF and other Protection Factors will improve significantly with the availability of true broad-spectrum sunscreens rather than conventional UVB-biased sunscreens, because uniform protection profiles lead to protection independent of the action spectrum of the endpoint and the UV-radiation source.
THE EFFECT ON THE RATE OF UREA EXCRETION OF CARMINE DEPOSITION IN THE CELLS OF THE RENAL TUBULES
Authors: Eaton M. MacKay, Lois Lockard MacKay
Journal: The Journal of Experimental Medicine (1930)

The evidence that urea is present in high concentration in the cells of the convoluted tubules of the kidney and is passing through these cells has been reviewed. Following the deposition of a large amount of carmine in the cells of the convoluted tubules the rate of urea excretion, as measured by the relation of the rate of urea excretion to the blood urea concentration, is increased. This is interpreted as due to blockage or damage to the cells of the convoluted tubules which interferes with their usual function of absorption of urea and other substances from the glomerular filtrate and hence increases the amount of urea which reaches the bladder urine at a given blood urea concentration.