tbuckley/cabot-search huggingface dataset:
Allogeneic transplantation following a reduced-intensity conditioning regimen in relapsed/refractory peripheral T-cell lymphomas: long-term remissions and response to donor lymphocyte infusions support the role of a graft-versus-lymphoma effect
Authors: A Dodero, F Spina, F Narni, F Patriarca, I Cavattoni, F Benedetti, F Ciceri, D Baronciani, R Scimè, E Pogliani, A Rambaldi, F Bonifazi, S Dalto, B Bruno, P Corradini
Journal: Leukemia (2011)
Textbook of Diagnostic Ultrasonography
Authors: Donald L. King
Journal: JAMA (1984)

Best buy in its class is the rating given the second edition of this comprehensive overview of the field of diagnostic ultrasonography. The editor has achieved her goal of presenting all areas of sonography in one textbook with ample illustrations and lucid text. The scope and clarity of this book reflect the editor's strong clinical orientation and long experience as an accomplished educator in this field.  The first six chapters present the basics of ultrasound physics and technology in a highly readable and easily understandable manner. If read and understood by current practitioners and students, many common interpretive errors and misconceptions regarding texture, artifacts, and resolution would be avoided. The next 11 chapters are devoted to an exposition of cross-sectional anatomy, scanning techniques, and clinical detail of abdominal ultrasonography. New chapters have been added to this edition covering sonography of the breast, neonatal skull, and superficial organs. These are followed
Variations in the hereditary patterns of factor VIII complex in a large kindred: Coexistence of hemophilia a with von willebrand
Authors: S. Tavori, I. Tatarsky
Journal: American Journal of Hematology (1984)

Coagulation studies and clinical observations were carried out in 47 members belonging to three generations in one kindred. Classical Hemophilia A, Von Willebrand (VWD) variants, and normal individuals were revealed in this study. The coexistence of Hemophilia A and VWD in different siblings of the same progenitors indicates the difficulty to distinguish between these two major factor VIII abnormalities as two different traits. A hypothesis based on these findings is elaborated.
Successful hybrid NOTES resection of early gastric cancer in a patient with concomitant advanced colon cancer
Authors: S. Park, H. Chun, B. Keum, Y. Seo, Y. Jeen, S. Um, C. Kim, H. Ryu, S.-S. Park, J. Kim
Journal: Endoscopy (2010)

NOTES (natural orifice transluminal endoscopic surgery) is currently of greatest interest to endoscopists and laparoscopic surgeons [1] [2] [3]. Early gastric cancer (EGC) is generally managed with endoscopic submucosal resection (ESD) if indicated. We present a case of EGC removed by hybrid NOTES, with a concomitant colon cancer resected via laparoscopic colectomy.
The evidence base for shaken baby syndrome
Authors: Robert M Reece
Journal: BMJ (2004)

EDITOR—In challenging the diagnosis of shaken baby syndrome in their recent editorial Geddes and Plunkett make a number of serious errors in interpreting the research on this issue, and they display a worrisome and persistent bias against the diagnosis of child abuse in general.1

In their opening sentence Geddes and Plunkett describe shaking a child to “produce whiplash forces that result in subdural and retinal bleeding,” omitting the most important element in this condition: brain injury itself. They elaborate that the “theory” of shaken baby syndrome rests on some core assumptions, including that “the injury an infant receives from shaking is invariably severe.”

This is in conflict with the research of Alexander et al, Ewing-Cobbs et al, Kemp et al, and Jenny et al, who found that 30%-40% of newly diagnosed shaken baby cases had medical evidence of previously undiagnosed head injury.2–5 These infants had such mild or non-specific symptoms and signs that their trauma was previously not diagnosed. The diagnosis was ultimately made when the children had subsequent severe episodes of abuse, with computer tomographic evidence of both acute and older subdural haematomata and brain injuries.

Geddes and Plunkett then consider retinal haemorrhages. Lantz et al, in the same issue, question the specificity of perimacular folds in abusive head trauma in infancy.6 They conclude from a literature review that there was no support for the contention that perimacular folds are pathognomonic for abusive head injury. Geddes and Plunkett applied these authors' conclusions not only to perimacular folds but also to retinal haemorrhages.

Although research on the subject of inflicted childhood neurotrauma—over 600 peer reviewed articles—does not claim that retinal haemorrhages are pathognomonic for …
Chronic treatment with amiodipine, but not nifedipine, improves enhanced vascular contractility in cardiomyopatic hamsters; a possible explanation for the results of PRAISE study?
Authors: A. Sato, N. Tomioka, S. Watanabe, H. Okamoto, M. Fukao, I. Sakuma, Y. Hattori, M. Kanno, A. Kitabatake
Journal: Journal of the American College of Cardiology (1998)
Adverse Drug Reactions: Getting Information Back From medWatch
Authors: Cheryl L. Vogt
Journal: JAMA (1994)

<h3>To the Editor.</h3> —The Food and Drug Administration's (FDA's)MEDWATCHprogram represents a major advance in postmarketing surveillance.<sup>1,2</sup>In order to sustain and promote reporting, however, a further step can be taken. Just as health professionals voluntarily submit information tomedWATCH, health professionals should be able to obtain information fromMEDWATCHas well. An example serves to illustrate this point. An otherwise healthy patient who was receiving a hypnotic drug and an antidepressant suddenly developed severe anemia (October 1993). The physician, concerned about the possibility of drug-induced anemia, requested help from a drug information center. The drug information pharmacist was not able to obtain any detailed information from either manufacturer on this adverse effect, other than the fact that isolated cases of bone marrow suppression had been reported. At the physician's suggestion, the pharmacist contacted the FDA in an attempt to learn more about the isolated cases of
302 TGF-BETA-DEPENDENT PROLIFERATION ARREST OF HEPTOCYTES AND DUCTULAR REACTION CONTRIBUTE TO HBV-ASSOCIATED LIVER FIBROGENESIS VIA NOTCH SIGNALING
Authors: H.-L. Weng, J. Li, L. Ciuclan, C. Meyer, T. Huang, P. Mertens, M. Singer, S. Dooley
Journal: Journal of Hepatology (2009)
Long-term decline in intelligence among adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiation
Authors: Kevin R. Krull, Nan Zhang, Aimee Santucci, Deo Kumar Srivastava, Matthew J. Krasin, Larry E. Kun, Ching-Hon Pui, Leslie L. Robison, Melissa M. Hudson, Gregory T. Armstrong
Journal: Blood (2013)
Microcytosis. Its significance and evaluation
Authors: M. H. Steinberg
Journal: JAMA (1983)

Smaller-than-normal RBCs (microcytosis) are commonly detected as a by-product of RBC counts measured by electronic particle counters. Their presence provides a clue to the existence of iron deficiency, thalassemia, and other less common disorders. The differential diagnosis of microcytosis is discussed, an approach to its evaluation is outlined, and illustrative cases that typify several causes of microcytosis are presented. (<i>JAMA</i>1983;249:85-87)
REGULATION OF THE SECONDARY ANTIBODY RESPONSE IN VITRO
Authors: Charles T. Ambrose
Journal: The Journal of Experimental Medicine (1969)

Two opposite effects of actinomycin D on antibody synthesis have been studied in organ cultures of rabbit lymph node fragments. These cultures were prepared from previously primed rabbits and stimulated with antigen(s) on day 0 to yield a secondary response, whose inductive phase extended to about day 9 and whose productive phase may last for several months in the serum-free medium described here. Concentrations of actinomycin D above 0.01 microM (0.012 microg/ml) produce inhibition of antibody synthesis during both phases of the response. However, antibody synthesis is about 10 times more sensitive to inhibition by this drug when it is added during the inductive phase than during the productive phase. During the latter phase, synthesis is more rapidly terminated as the drug level approaches 10 /microM (12.5 microg/ml). At this level the 50% synthesis time is about 2.8 hr, which is identical with that found when 5-10 microM puromycin is added to the medium of parallel cultures. Transient enhancement of antibody synthesis is frequently produced by a brief exposure to low levels of actinomycin D (generally less than 0.01 microM). Enhancement appears in precise temporal association with actinomycin pulses added for 2 days or less only between days 6 and 16. This apparent enhancement of antibody synthesis resembles the increased enzyme synthesis described by Garren et al. (6) and led to a search for an antibody-inhibitory material (AIM) whose synthesis might be stopped preferentially by low levels of the drug. Stimulated lymph node cultures produce between days 6 and 15 a nondialyzable material which inhibits antibody synthesis during the productive phase of heterologous antigen-antibody culture systems. Just as enhancement with low levels of actinomycin D appears within 2 hr after the drug has been added to cultures, so inhibition occurs within 4 hr of adding AIM to cultures during their productive phase. These observations suggest that AIM is analogous to the translational "repressor" postulated by Garren et al. (6). AIM has relevance in two areas of immunology: (a) it may be the explanation for many examples of antigenic competition, and (b) it may represent a normal control mechanism for the productive phase.
Abstract 4528: Small molecules inhibitory for MDMX expression activate p53 and induce apoptosis
Authors: Hongbo Wang, Xujun Ma, Shumei Ren, Chunhong Yan
Journal: Cancer Research (2010)

Abstract P53 inactivation caused by aberrant expression of its major regulators(e.g, MDM2 and MDMX) contributes to 50% of human cancers. Recent studies have demonstrated that restoration of p53 activity by counteracting p53 repression is a promising anti-cancer strategy. Although agents(e.g., Nutlin-3a) disrupting the MDM2-p53 interaction can inhibit tumor growth, they are less effective in cancer cells with high MDMX expression levels. MDMX binds to p53 and serves as a major p53 antagonist by mainly repressing its transcriptional activity. Here we reported the identification of two samll molecules inhibitory for MDMX expression through high-throughput screening. Treatments of MCF-7 cells with these MDMX inhibitors dramatically increased the stability of p53, leading to elevated expression of proapoptotic genes(e.g., PUMA, Bax, and PIG3). These results argue for a recent notion that MDMX is a major regulator of the p53 stability. While they exerted limited effects on cell cycle progression, this new class of small-molecule p53 activitors induced MCF7 cells to undergo apoptosis. However, the MDMX inhibitors only modestly enhanced p53 activition induced by Nutlin-3a. We conclue that small molecules targeting MDMX expression would be of therapeutic benefits and be useful in dissecting the p53 network through chemical biological approaches. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4528.
Addition of the selective aldosterone receptor antagonist eplerenone to ACE inhibition in heart failure: effect on endothelial dysfunction
Authors: Andreas Schäfer, Daniela Fraccarollo, Steven K Hildemann, Piet Tas, Georg Ertl, Johann Bauersachs
Journal: Cardiovascular Research (2003)

To investigate the effects of adding the selective aldosterone receptor antagonist eplerenone to ACE inhibition on endothelium-dependent vasodilation in rats with chronic heart failure (CHF).Addition of the non-selective aldosterone antagonist spironolactone to ACE-inhibitors reduces mortality and morbidity in CHF and improves endothelial vasomotor dysfunction, but is associated with considerable side-effects.Starting 10 days after extensive myocardial infarction (MI) or sham-operation, Wistar rats were treated either with placebo, the ACE inhibitor trandolapril (TR, 0.3 mg/kg body weight per day), the selective aldosterone receptor antagonist eplerenone (EPL, 100 mg/kg per day) or a combination of both for 9 weeks.Maximum acetylcholine-induced, nitric oxide-dependent relaxation was significantly attenuated in aortic rings from rats with CHF compared with sham-operated animals (R(max) 55% vs. 87%). EPL alone slightly and TR significantly improved NO-mediated relaxation (CHF-EPL 66%; CHF-TR: 78%), while treatment with both EPL and TR completely restored endothelium-dependent vasorelaxation (CHF-EPL-TR: 83%). Aortic superoxide formation was significantly increased in rats with CHF compared with sham-operated animals, but was normalised by treatment with EPL or TR-EPL. Expression of the endothelial nitric oxide synthase was decreased in CHF and normalised in all treatment groups.In experimental CHF, the selective aldosterone antagonist EPL reduced the increased vascular superoxide formation. Although a combination of TR and EPL normalised endothelium-dependent relaxation, ACE inhibition as a monotherapy was almost equally effective.
Cigarette Smoking and Risk of Stroke in Middle-Aged Women
Authors: G A Colditz, R Bonita, M J Stampfer, W C Willett, B Rosner, F E Speizer, C H Hennekens
Journal: New England Journal of Medicine (1988)

It is known that cigarette smoking is associated with increased risk of both thrombotic and hemorrhagic stroke among men. To test for such an association among women, we examined the incidence of stroke in relation to cigarette smoking in a prospective cohort study of 118,539 women 30 to 55 years of age and free from coronary heart disease, stroke, and cancer in 1976. During eight years of follow-up (908,447 person-years), we identified 274 strokes, comprising 71 subarachnoid hemorrhages, 26 intracerebral hemorrhages, 122 thromboembolic strokes, and 55 strokes about which information was insufficient to permit classification. The number of cigarettes smoked per day was associated positively with the risk of stroke. Compared with the women who had never smoked, those who smoked 1 to 14 cigarettes per day had an age-adjusted relative risk of 2.2 (95 percent confidence interval, 1.5 to 3.3), whereas those who smoked 25 or more cigarettes per day had a relative risk of 3.7 (95 percent confidence interval, 2.7 to 5.1). For women in this latter group, the relative risk of subarachnoid hemorrhage was 9.8 (95 percent confidence interval, 5.3 to 17.9), as compared with those who had never smoked. Adjustment for the effects of relative weight, hypertension, diabetes, history of high cholesterol, previous use of oral contraceptives, postmenopausal estrogen therapy, and alcohol intake did not appreciably alter the association between cigarette use and incidence of stroke. These prospective data support a strong causal relation between cigarette smoking and stroke among young and middle-aged women.
Plight of elderly people who are made homeless in hospital
Authors: T. Downes, K S Channer
Journal: BMJ (2001)

Health needs of asylum seekers and refugees Specific treatments are effective in cases of post-traumatic stress disorderEditor-Burnett and Peel described the social and family background regarding asylum seekers and refugees in Britain. 1 2 Unfortunately their articles make many confusing generalisations and have several inaccuracies regarding mental health.Burnett and Peel say that the most therapeutic event for a child can be to become part of the local school community. 2Everybody would agree that schools
Common Skin Disorders
Authors: Joseph B. Jerome
Journal: JAMA (1980)

Intended for the physician who treats skin diseases, this book is especially designed to be of service to the nondermatologist as well as to the dermatologist who is in the process of establishing his practice. To the former it provides treatment guidelines for those skin diseases that the general practitioner is most likely to see and that can be treated successfully with the approaches used by Dr Epstein and set forth simply and lucidly in this volume. For both, Dr Epstein provides office procedure guidelines and especially a series of patient instruction sheets that can serve as the nucleus for each practitioner's own set of similar patient aids. Even established dermatologists may find much of value in the patient instruction sheets provided here. This volume contains few illustrations and is almost devoid of disease descriptions, but provides specific, detailed treatment directions for about 30 common skin disorders. Dr Epstein usually
Anisotropic Lipids and Urinary Cholesterol Excretion
Authors: David E. Comings
Journal: JAMA (1963)

IT IS WIDELY APPRECIATED that urinary anisotropic lipid bodies are of diagnostic importance in the nephrotic syndrome. Detailed descriptions of these structures are lacking, however, and it is assumed that any highly refractile, anisotropic body displaying the Maltese cross under polarized light has diagnostic significance. Routine polariscopic examination of urine sediments, including those from normal subjects, disclosed the frequent occurrence of pseudoanisotropic bodies displaying the characteristic black Maltese cross. True and pseudoanisotropic lipid bodies were quantitated and correlated with urinary protein and cholesterol excretion and with serum protein and lipids in normal controls and in patients with various types of renal disease. The study of urinary cholesterol excretion utilizing an ultramicrotechnique was of considerable interest when compared with the values obtained with previous techniques. <h3>Methods</h3> The present study is based on 439 urine examinations in 130 individuals. These included 16 normal controls, 3 nonrenal hypercholesteremic controls, 21 patients with
Letter on Assurance Office Fees
Authors: W. Sweeting
Journal: BMJ (1842)

room.The bowels are open; pupil contracted, although he had belladonna applied previously.His left eye beinig the worst, was operated on, as in the former case.Sir John ordered about twelve ounces of blood to be takein from the arm, some opening pills, and the eye to be dressed daily with ceratum belladonnte.July 30.Can see light; continue belladonna; doing well.August 2. Omit the belladonna.6. Dismissed this morning.Ordered to take some opening pills, and to drop the solution of nitrate of silver into the eye twice a-day.
Treatment of Peripheral Diabetic Neuropathy
Authors: William W. Weddington
Journal: JAMA (1978)

To the Editor.—  The recent BRIEF REPORT by Davis and associates prompts me to share my observations about the use of tricyclic antidepressants and phenothiazines for the management of pain syndromes.  In my work as a consulting psychiatrist to three university-affiliated pain clinics located in two different geographic settings, I have noted the frequent use by neurosurgeons and anesthesiologists of amitriptyline and fluphenazine as well as amitriptyline and chlorprothixene for the management of chronic pain. The drugs are prescribed in low doses, and analgesic results are usually evident within three to four days, thus being consistent with the results reported by Davis and associates. Although I wonder about the operation of the placebo factor, I now find myself using these drugs for certain pain syndromes and noting some success.  Although these drugs are not addicting and tolerance does not occur, they are not without hazard. The tricyclics, especially amitriptyline, have
Interstitial Nephritis Caused by Trimethoprim-Sulfamethoxazole in Renal Transplant Recipients
Authors: Edwin J. Smith
Journal: JAMA (1980)

THE COMBINATION drug trimethoprim-sulfamethoxazole is widely used in renal transplant recipients to treat urinary tract infections and opportunistic infections with organisms such as<i>Pneumocystis carinii</i>and<i>Nocardia</i>, and has recently been recommended as prophylaxis against<i>Pneumocystis</i>pneumonitis. To our knowledge, deterioration of renal allograft function from interstitial nephritis in association with trimethoprim-sulfamethoxazole administration has been recorded only once.<sup>1</sup>The following reports suggest that interstitial nephritis caused by trimethoprim-sulfamethoxazole may occur more frequently and that the drug should be used with caution in renal transplant recipients. <h3>Report of Cases</h3><h3>Case 1.—</h3> A 50-year-old woman with chronic glomerulonephritis received a renal transplant from a cadaver donor on Sept 28, 1975. Initial renal function was good. In November 1975 she had a rejection episode that responded to intravenous administration of methylprednisolone, 30 mg/kg. On Jan 14, 1976, a staphylococcal septicemia developed and was treated with nafcillin sodium. Ten days later she again
Serum Sickness and Immune Complexes
Authors: Bruce C. Gilliland
Journal: New England Journal of Medicine (1984)

The article by Lawley et al.1 in this issue of the Journal provides an excellent description of the clinical and immunologic features of serum sickness in patients with bone-marrow failure who received antithymocyte globulin in horse serum. This group of patients, similar to those described by von Pirquet and Schick in 1905,2 acquired fever, skin lesions, arthralgias, lymphadenopathy, gastrointestinal symptoms, and mild proteinuria 8 to 13 days after beginning therapy. The relation of the formation of immune complexes to the development of clinical manifestations in these patients is well documented. A rise in the level of immune complexes was accompanied . . .
68Ga-DOTANOC PET/CT in Patients With Carcinoma of Unknown Primary of Neuroendocrine Origin
Authors: Niraj Naswa, Punit Sharma, Abhishek Kumar, Ramya Soundararajan, Rakesh Kumar, Arun Malhotra, Ariachery C. Ammini, Chandrashekhar Bal
Journal: Clinical Nuclear Medicine (2012)

Objective: To evaluate the role of 68Ga-DOTANOC (68Gallium-labeled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-NaI3-octreotide) PET/CT for localization of the primary tumor in patients with carcinoma of unknown primary of neuroendocrine origin. Material and Methods: Twenty patients (median age, 55 years; male 10) with histopathologically proven metastatic neuroendocrine tumor and no localization of primary tumor on conventional imaging were included in the study. PET/CT was done after injection of 132–222 MBq (4–6 mCi) of 68Ga-DOTANOC. Images were evaluated by 2 experienced nuclear medicine physicians both qualitatively as well as quantitatively (maximum standardized uptake value). Histopathology (when available) and/or follow-up imaging with biochemical markers were taken as reference standard. Results: 68Ga-DOTANOC PET/CT localized the primary tumor in 12/20 (60%) patients. Midgut was the most common site of primary tumor (n = 9); duodenum (4), ileum (4), and colon (1). In 1 patient each the primary was localized to the pancreas, stomach, and lung. In these 12 patients, significant correlation was found between maximum standardized uptake value of primary tumor and metastasis (ρ = 0.615; P = 0.041). Even in patients in whom no primary tumor was localized, additional sites of metastatic disease were observed when compared with conventional imaging, mostly in lymph nodes and bones. There was a change in management in 3/20 patients (15%), who underwent surgery. In the remaining 17 patients, demonstration of somatostatin receptor expression by PET/CT made them suitable candidate for peptide receptor radionuclide therapy. Conclusion: 68Ga-DOTANOC PET/CT seems to be a promising modality for detecting primary tumor in patients with carcinoma of unknown primary of neuroendocrine origin.