tbuckley/cabot-search huggingface dataset:
Saccular Dilatations in the LeVeen Shunt
Authors: JOSEPH C. O'LAUGHLIN
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 December 1979Saccular Dilatations in the LeVeen ShuntJOSEPH C. O'LAUGHLIN, D.O., JAMES W. HOFTIEZER, M.D., DONALD C. GERHARDT, M.D.JOSEPH C. O'LAUGHLIN, D.O.Search for more papers by this author, JAMES W. HOFTIEZER, M.D.Search for more papers by this author, DONALD C. GERHARDT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-6-928_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The LeVeen shunt has proved to be a significant adjuvant for managing refractory ascites. A number of complications have been reported, however, including pulmonary edema (1), overt and subclinical disseminated intravascular coagulation (2), subcutaneous and gastrointestinal bleeding (3, 4), recurrent laryngeal nerve damage, pneumothorax, and shunt clotting (4), external leakage of ascitic fluid, sepsis, and noninfectious fevers (4, 5). We recently observed an instance of saclike dilatations along a catheter tract, a complication not previously reported, to our knowledge, the appearance of which may reflect loss of shunt patency.A 56-year-old white woman was admitted to the...References1. DARSEEANSLEYFULLENWEIDERRIKKERSNORDLINGERHEYMSFIELD JJJLBS. Hemodynamics of LeVeen-valve pulmonary edema. Clin Res. 1978;26:759A. Abstract. Google Scholar2. HARMONDEMIRJIANELLMANFISCHER DZFJ. Disseminated intravascular coagulation with the peritoneovenous shunt. Ann Intern Med. 1979;90:774-6. LinkGoogle Scholar3. ANSLEYBETHELBOWENWARREN JRPW. Effect of peritoneovenous shunting with the LeVeen valve on ascites, renal function, and coagulation in six patients with intractable ascites. Surgery. 1975;83:181-7. Google Scholar4. LEVEENWAPNICKDIAZGROSBERGKINNEY HSCSM. Ascites: its correction by peritoneovenous shunting. Curr Probl Surg. 1979;16(February):47-57. Google Scholar5. LEVEENWAPNICKGROSBERGKINNEY HSSM. Further experience with peritoneovenous shunt for ascites. Ann Surg. 1976;184:574-81. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Missouri Medical Center Columbia, MO 65212 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPeritoneovenous shunt in the management of ascites and the hepatorenal syndrome 1 December 1979Volume 91, Issue 6Page: 928-929KeywordsAscitesCathetersDisseminated intravascular coagulationEdemaFeversHemorrhageNervesSepsis Issue Published: 1 December 1979 PDF DownloadLoading ...
Successful Treatment of Neuroblastoma
Authors: Henry W. Hudson, John W. Chamberlain, Frederick B. Becker
Journal: New England Journal of Medicine (1952)

IN 1864 Virchow1 described a patient with neuroblastoma. Pepper,2 in 1901, and Hutchison,3 in 1907, described clinical features of the tumor. Rosendal4 in 1942 collected some 300 cases, with few successful treatments. Lehman5 in 1917 reported the first successful extirpation and in 1932 reported the fifteen-year survival of this patient.6 In 1940 Farber7 expanded the observations of Cushing and Wolbach;8 he remarked that the tumors might undergo spontaneous hemorrhage with necrosis and disappear and that others might mature into benign ganglioneuromas. He stated that permanent cure, even after metastasis, was possible. Ladd and Gross9 indicate probable cure of 7 of . . .
Chemotherapy and imatinib‐induced molecular remission in lymphoid blast crisis after 20 years of “untreated” chronic myeloid leukemia
Authors: Ebru Koca, Ferda Sevimli, Deniz Cetiner, Ibrahim C. Haznedaroglu, Nilgun Sayinalp, Yahya Büyükasik, Hakan Goker, Osman Ozcebe
Journal: American Journal of Hematology (2006)
Hospitalization for heart failure in the presence of a normal left ventricular ejection fraction
Authors: Marc Klapholz, Matthew Maurer, April M. Lowe, Frank Messineo, Jay S. Meisner, Judith Mitchell, Jill Kalman, Robert A. Phillips, Richard Steingart, Edward J. Brown, Robert Berkowitz, Robert Moskowitz, Anita Soni, Donna Mancini, Rachel Bijou, Khashayar Sehhat, Nikita Varshneya, Marrick Kukin, Stuart D. Katz, Lynn A. Sleeper, Thierry H. Le Jemtel
Journal: Journal of the American College of Cardiology (2004)
1034-212 5-Hydroxytryptamine 4 (5HT4) receptor mRNA processing in favor of the ‘b’ isoform correlates with left atrial dilatation and may predispose to atrial fibrillation after coronary artery bypass grafting
Authors: Shamil Yusuf, Christiane Fenske, Chrysoula Delageorgou, Nicholas D Carter, Naab Al Saady, Nidal Maarouf, A.John Camm
Journal: Journal of the American College of Cardiology (2004)
Textbook of Physical Diagnosis: History and Examination
Authors: Jacob Locke
Journal: JAMA (1994)

One of the first major clinical hurdles a medical student faces is the acquisition of skills necessary to perform a thorough history and physical. It is true that the artful and inquisitive physician will often find much of the diagnosis from the history. Combining this with a skilled physical exam, the student doctor-to-be can benefit from all the patient has to offer. Swartz'<i>Textbook of Physical Diagnosis</i>, second edition, will provide a wealth of information to the young medical, dental, or nursing student requiring a thorough and complete review of the history and physical examination. Some 644 pages are liberally filled with over 700 illustrations, more than 100 in full color and many more in sharp two-color mode. The book is thoughtfully arranged into four general sections of interviewing technique, physical diagnosis by system (eg, heart, abdomen, chest), evaluation of specific patients, and the brief section "Putting the Data to
Playing Doctor: Television, Storytelling, and Medical Power
Authors: Tony Miksanek
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Depression-Reply
Authors: Martin B. Keller
Journal: JAMA (1983)

<h3>In Reply.—</h3> It is possible that Professor Thisted missed the statement in our article that duration of the episode before entry is statistically significantly associated with the composite treatment score, the antidepressant dose level, neuroleptic drugs, and minor tranquilizers. Table 6 indicates these associations and their descriptive levels of significance, together with the statistical tests. On page 1853, first column, we state: "Duration of the episode before entry, severity, GAS score... were strongly associated with two or more treatment modalities." The beginning sentence of that section refers to Table 6. Those are the statistical facts that we reported. It is also possible that we may have inadvertently misled Professor Thisted in the following way. On page 1852, we state that "even selecting a group of patients whose depression began at least three or six months before entry does not lead to a substantial increase in treatment intensity." Our intent, apparently
Erratum to ‘Unexpected original property of elastin derived proteins: spontaneous tight coupling with natural and synthetic polymers’ [Biomaterials 19 (1998) 147–155]
Authors: S. Dutoya, F. Lefebvre, C. Deminières, F. Rouais, A. Verna, A. Kozluca, A. Le Bugle, M. Rabaud
Journal: Biomaterials (1999)
Nosocomial Viral Hepatitis B
Authors: DAVID R. SNYDMAN
Journal: Annals of Internal Medicine (1976)

In a 2-month period four cases of hepatitis B occurred in hospital staff. Three months later two patients, hospitalized for open-heart surgery when the staff members had been infected, developed acute hepatitis B. Sera from all six ill individuals were subtype ayw and e-determinant positive. Epidemiologic investigation showed that the four staff had been exposed 3 months earlier to an asymptomatic hepatitis B surface antigen-positive (HBsAg) patient who was also e positive. To determine transmission from staff to patients study of 17 open-heart surgery patients was undertaken. Four of 17 were either HBsAg or anti-HBs positive. No correlation between infection and contact with three of four ill staff members or receipt of blood products was noted; however, 22 (46%) of 48 arterial blood gas specimens had been obtained from infected patients by one staff member, an inhalation therapist; this compared with seven (4%) of 157 specimens she obtained from control subjects (P < 0.001). Furthermore, she handled indwelling arterial cannulae 25 (76%) of 33 times in infected patients compared with three (3%) of 95 times in control subjects (P < 0.001). Transmission may have occurred via the arterial cannulae from a severe exudative dermatitis on the therapist's hands.
Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes
Authors: Johanna R. Rochester, Ashley L. Bolden
Journal: Environmental Health Perspectives (2015)

Increasing concern over bisphenol A (BPA) as an endocrine-disrupting chemical and its possible effects on human health have prompted the removal of BPA from consumer products, often labeled "BPA-free." Some of the chemical replacements, however, are also bisphenols and may have similar physiological effects in organisms. Bisphenol S (BPS) and bisphenol F (BPF) are two such BPA substitutes.This review was carried out to evaluate the physiological effects and endocrine activities of the BPA substitutes BPS and BPF. Further, we compared the hormonal potency of BPS and BPF to that of BPA.We conducted a systematic review based on the Office of Health Assessment and Translation (OHAT) protocol.We identified the body of literature to date, consisting of 32 studies (25 in vitro only, and 7 in vivo). The majority of these studies examined the hormonal activities of BPS and BPF and found their potency to be in the same order of magnitude and of similar action as BPA (estrogenic, antiestrogenic, androgenic, and antiandrogenic) in vitro and in vivo. BPS also has potencies similar to that of estradiol in membrane-mediated pathways, which are important for cellular actions such as proliferation, differentiation, and death. BPS and BPF also showed other effects in vitro and in vivo, such as altered organ weights, reproductive end points, and enzyme expression.Based on the current literature, BPS and BPF are as hormonally active as BPA, and they have endocrine-disrupting effects.Rochester JR, Bolden AL. 2015. Bisphenol S and F: a systematic review and comparison of the hormonal activity of bisphenol A substitutes.
Embracing Oral Cholera Vaccine — The Shifting Response to Cholera
Authors: Jean William Pape, Vanessa Rouzier
Journal: New England Journal of Medicine (2014)

Despite evidence of the safety and efficacy of oral cholera vaccines, they were not included in the prevention package during the 2010 Haitian cholera epidemic. But some major obstacles to the use of OCVs in cholera outbreaks have since been overcome.
Abstract 2246: <i>Non-invasive</i> ablation of the Left Superior Pulmonary Vein-Left Atrial junction using stereotactic focussed radiation
Authors: Arjun Sharma, Patrick Maguire, Thilaka Sumanaweera, Douglas Wong, Richard Marshall, Luis Fajardo, Thomas Fogarty
Journal: Circulation (2007)

Introduction: High energy x-ray irradiation from a linear accelerator mounted on a robot arm has recently been used to produce ablation of cardiac tissue in swine. This device is currently used in patients for diverse indications requiring careful targeting, from tumors to trigeminal neuralgia. Purpose: This study was to determine if this method of energy delivery can be used to target potential arrhythmogenic sites such as the left superior pulmonary vein-left atrial junction. Method: Hanford-Sinclair mini-swine (40–70kg)(n=9) were studied under anesthesia. The animals underwent radiation (x-rays, 20 – 80 Gray) using a computer controlled robotic arm (Cyberknife) which focussed the x-ray beam on a preselected target. Targeting was done using either surgically implanted fiducials or fully non-invasively using a CT scan. A proprietary system was used to radiate the target while minimizing the dose to surrounding structures. Motion compensation was made for respiration during radiation, but no cardiac contractile motion compensation was made. The animals were then studied 4 – 8 weeks later with construction of cardiac voltage maps using CARTO (Biosense-Webster). Following this the animals were sacrificed and specimens taken for pathology. Results: All animals survived treatment. Radiation to the left superior pulmonary vein eliminated local electrograms with voltage less than 0.1mv. Pathology specimens showed histologic changes consistent with an area of discrete myocyte damage. There was no evidence of phrenic nerve injury. Limitations: This study was done in swine and human pulmonary vein response to this treatment is unknown. This model was arrhythmia free and the efficacy of this treatment for atrial fibrillation is unknown. Conclusions: Selective targeting of cardiac arrhythmogenic sites can be done using stereotactically focussed external radiation with respiratory motion compensation. The left superior pulmonary vein can be ablated without compensation for cardiac contractility.
1108-109 Low hemoglobin is an independent predictor of adverse fatal and nonfatal outcomes in both reduced and preserved systolic function chronic heart failure: Findings from the candesartan in heart failure assessment of reduction in mortality and morbidity program (CHARM)
Authors: John J McMurray, Chim C Lang, Karl Swedberg, Jan Östergren, Christopher B Granger, Eric Michelson, James B Young, Bertil Olofsson, Mark Dunlap, Salim Yusuf, Marc A Pfeffer
Journal: Journal of the American College of Cardiology (2004)
A1.35 Cryopreservation of human synovial tissue for biobanking purposes
Authors: M de Vries, MGA Broeren, MB Bennink, van Lent Plem, PM van der Kraan, MI Koenders, FAJ van de Loo
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background and objectives</h3> Human synovial tissue derived from joint surgery of osteoarthritis (OA) and rheumatoid arthritis (RA) patients is valuable material for studying fundamental research questions. However, due to improved treatment options for these patients less joint replacement surgery is needed and less articular material becomes available for research. Additionally, performing a standardised comparative experiment with fresh tissue is difficult as material is scarce and infrequently available. It would be ideal to store and collect all this valuable tissue for later use. Therefore, a cryopreservation method has to be developed and importantly, the cryopreserved tissue should perform as freshly obtained material. <h3>Materials and methods</h3> We used bovine metacarpophalangeal synovial tissue as a model. The inner layers of the joint capsule are isolated and 3 mm biopsies are taken. Human synovial tissue is derived, with informed consent, from joint surgery and also frozen as 3 mm biopsies. Cryosections are made to prove synovial origin. Bovine and human biopsies are cryopreserved by slow freezing using several cryoprotectant (CPA) solutions (Cryostor CS2 and standard freezing medium containing 10% DMSO and 10% FCS). For slow freezing a Mr. Frosty is used assuring a temperature decrease of 1°C/min. Thawing has been performed at 37°C, followed by quick removal of the CPA solution. Viability has been determined by MTT, XTT and ATP assays. <h3>Results</h3> Histologically, the bovine synovial lining layer is comparable to normal human synovium. No differences were observed between freshly isolated and frozen synovium by HE staining on paraffin sections. Culturing cryopreserved bovine synovial tissue showed viability of up to 70% as determined by MTT, XTT and ATP assays. Furthermore, the standard CPA solution gives slightly higher viability values compared to the Cryostor medium. A first test with human RA tissue showed even higher viability, almost reaching the fresh values, as determined by the XTT assay. When comparing the viability assays, negative control values (tissue frozen-thawed several times without CPA solution) are lowest for the ATP assay indicating this assay could be most optimal for determining viability. <h3>Conclusion</h3> The first results of the viability testing after cryopreservation are promising. However, further testing, also with additional CPA solutions is required to validate the cryopreservation method. Next to general viability, preservation of the pathologic response is important. Experiments are ongoing to determine cytokine secretion after cryopreservation and this will shed some more light on the ability to preserve and biobank human synovial tissue.
Role of Genetic Testing for Screening and Prevention for Ovarian Cancer
Authors: Victor Grann, Maxine Ashby-Thompson
Journal: JAMA Internal Medicine (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Left ventricular pressure-volume and Frank-Starling relations in endurance athletes. Implications for orthostatic tolerance and exercise performance.
Authors: B D Levine, L D Lane, J C Buckey, D B Friedman, C G Blomqvist
Journal: Circulation (1991)

Endurance athletes have a high incidence of orthostatic intolerance. We hypothesized that this is related to an abnormally large decrease in left ventricular end-diastolic volume (LVEDV) and stroke volume (SV) for any given decrease in filling pressure.We measured pulmonary capillary wedge (PCW) pressure (Swan-Ganz catheter), LVEDV (two-dimensional echocardiography), and cardiac output (C2H2 rebreathing) during lower body negative pressure (LBNP, -15 and -30 mm Hg) and rapid saline infusion (15 and 30 ml/kg) in seven athletes and six controls (VO2max, 68 +/- 7 and 41 +/- 4 ml/kg/min). Orthostatic tolerance was determined by progressive LBNP to presyncope. Athletes had steeper slopes of their SV/PCW pressure curves than nonathletes (5.5 +/- 2.7 versus 2.7 +/- 1.5 ml/mm Hg, p less than 0.05). The slope of the steep, linear portion of this curve correlated significantly with the duration of LBNP tolerance (r = 0.58, p = 0.04). The athletes also had reduced chamber stiffness (increased chamber compliance) expressed as the slope (k) of the dP/dV versus P relation (chamber stiffness, k = 0.008 +/- 0.004 versus 0.031 +/- 0.004, p less than 0.005; chamber compliance, 1/k = 449.8 +/- 283.8 versus 35.3 +/- 4.3). This resulted in larger absolute and relative changes in end-diastolic volume over an equivalent range of filling pressures.Endurance athletes have greater ventricular diastolic chamber compliance and distensibility than nonathletes and thus operate on the steep portion of their Starling curve. This may be a mechanical, nonautonomic cause of orthostatic intolerance.
Prevalence of adverse reactions to food in Germany – a population study
Authors: T. Zuberbier, G. Edenharter, M. Worm, I. Ehlers, S. Reimann, T. Hantke, C. C. Roehr, K. E. Bergmann, B. Niggemann
Journal: Allergy (2004)

A population study was performed to identify the prevalence of all kinds of adverse reactions to food.In a representative cross-sectional survey performed in 1999 and 2000 in Berlin, 13 300 inhabitants of all ages were addressed by questionnaire. This questionnaire was answered by 4093 persons. All respondents mentioning any sign of food intolerance or the existence of allergic diseases (n = 2298) were followed up by telephone and, in case food intolerance could not be ruled out by patient history, were invited to attend to the clinic for personal investigation including double-blind, placebo-controlled food challenge tests (DBPCFC).The self-reported lifetime prevalence of any adverse reaction to food in the Berlin population (mean age 41 years) was 34.9%. Eight hundred and fourteen individuals were personally investigated according to the guidelines. The point prevalence of adverse reactions to food confirmed by DBPCFC tests in the Berlin population as a mean of all age groups was 3.6% (95% confidence interval [3.0-4.2%]) and 3.7% in the adult population (18-79 years, 95% confidence interval [3.1-4.4.%]). Two and a half percent were IgE-mediated and 1.1% non-IgE-mediated, females were more frequently affected (60.6%). Based on a statistical comparison with available data of adults from the nationwide German Health Survey from 1998, adverse reactions to food in the adult population of Germany (age 18-79) were calculated with 2.6% [2.1-3.2%]).The study gives for the first time information about the point prevalence of both immunological and nonimmunological adverse reactions to food and underlines the relevance of this issue in public health. The data also show that an individualized stepwise approach including provocation tests is mandatory to confirm the diagnosis.
Sickle Cell Trait and Urinary Tract Infection During Pregnancy
Authors: Peggy J. Whalley, Frances G. Martin, Jack A. Pritchard
Journal: JAMA (1964)

The prevalence of asymptomatic bacteriuria and the relationship of asymptomatic bacteriuria to the development of clinically apparent urinary tract infection have been investigated in 475 pregnant women with sickle cell trait. The prevalence of asymptomatic bacteriuria was significantly higher among women with sickle cell trait than Negro women without sickle cell trait, being 13.9% in the former and 6.4% in the latter. The incidence of overt urinary tract infection developing during pregnancy as well as a previous history of urinary tract infection was significantly higher in bacteriuric women with sickle cell trait than in bacteriuric women whose red blood cells did not sickle. Urologic evaluation following delivery revealed that 19 of 33 bacteriuric women with sickle cell trait had radiographic abnormalities indicative of chronic pyelonephritis.