tbuckley/cabot-search huggingface dataset:
AI-25 * THE NOVEL c-MET INHIBITOR ALTIRATINIB (DCC-2701) INHIBITS TUMOR GROWTH AND INVASION IN A BEVACIZUMAB RESISTANT GLIOBLASTOMA MOUSE MODEL
Authors: Y. Piao, B. Smith, C. Thomas, L. Holmes, V. Henry, D. L. Flynn, J. de Groot
Journal: Neuro-Oncology (2014)

Glioblastoma with acquired resistance to bevacizumab therapy overexpresses c-MET which mediates tumor growth, EMT, invasion, and metastasis. We evaluated the expression level of total and phosphorylated c-MET (p-c-MET) and the inhibitory activity of altiratinib (DCC-2701), a novel c-MET/TIE2/VEGFR inhibitor (Deciphera Pharmaceuticals) that has demonstrated significant BBB penetration into the CNS. Four of 12 (30%) mesenchymal glioma stem cell lines (GSCs) highly expressed c-Met and were sensitive to altiratinib treatment in vitro for blocking cell viability. After HGF stimulation, the expression level of p-cMET was significantly increased in these 4 cell lines. Altiratinib markedly suppressed HGF stimulated p-c-MET expression in both paracrine (MET+) and autocrine (MET + /HGF+) GSC cell lines. In an intracranial glioma mouse model, animals were treated with bevacizumab (Bev) alone, altiratinib alone or the combination. Mice were euthanized at 3, 4 and 5 weeks. H&E staining revealed a significant reduction in tumor size in the combination group compared with the tumors treated with either agent alone. Altiratinib alone or combination with Bev treatment dramatically suppressed EMT and tumor invasion in vivo. This anti-invasive effect correlated with decreased N-cadherin and vimentin levels. In vivo, microvascular density was significantly inhibited in the groups treated with altiratinib and altiratinib plus Bev compared with control or the group treated with Bev alone. Similarly, F4/80+ BMDC cell infiltration was significantly suppressed in the groups treated with altiratinib and altiratinib plus Bev combination compared to control Bev-treated groups. In summary, our data indicated that altiratinib inhibited tumor growth, EMT and invasion both in vitro and in vivo. The combination of altiratinib and anti-VEGF therapy may provide a new strategy to overcome Bev resistance and prolong overall survival in patients with glioblastoma.
797-6 Recombinant Lys-Plasminogen Given Prior to, but not After, Tissue-Plasminogen Activator Markedly Improves Coronary Thrombolysis in Dogs
Authors: Living Chen, Wilmer W. Nichols, Tom G.P. Saldeen, Jawahar L. Mehta
Journal: Journal of the American College of Cardiology (1995)
THE ACTION OF OILS IN MUSCLE TISSUE
Authors: LOUIS H. JORSTAD
Journal: JAMA (1928)

In former studies from this laboratory we have shown that coal tar, mazola oil and other lipoid solvents remain encapsulated when introduced into the subcutaneous tissue of animals.<sup>1</sup>The degree of encapsulation and the nature of the tissue change in these capsules is governed by the particular dietary given the animal. The vitamin A fraction of the diet plays the major rôle in these changes.<sup>2</sup>On a low vitamin A dietary the oil remains in a single droplet, while on a high vitamin A dietary the oil breaks up into numerous smaller droplets. The degree of the breaking up of the coal tar or oil also varies with the oil or tar used. Mazola oil breaks up more readily than coal tar under otherwise similar conditions. It has been customary for many years to use one of the various mineral or animal oils as a vehicle for the
A Starry Night in Wyoming Against the Sky an Incongruous Shepherd
Authors: Bob Scher
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Yaa gene abrogates the major histocompatibility complex association of murine lupus in (NZB x BXSB)F1 hybrid mice.
Authors: R Merino, M Iwamoto, M E Gershwin, S Izui
Journal: Journal of Clinical Investigation (1994)

To investigate the specific contribution of select MHC class II genes on the development of murine lupus, H-2 congenic (NZB x BXSB)F1 hybrid mice bearing either H-2b/b, H-2d/b, or H-2d/d haplotypes were generated. We compared the clinical development (autoantibody production and glomerulonephritis) of systemic lupus erythematosus (SLE) in these three F1 hybrids in the presence or absence of the mutant gene, Yaa (Y chromosome-linked autoimmune acceleration), which normally accelerates the progression of murine SLE. (NZB x BXSB)F1 hybrid female mice bearing either the H-2b/b or H-2d/b haplotype developed a rapid course of severe SLE, while the appearance of disease was markedly delayed in H-2d/d hybrid females. However, in the presence of the Yaa gene, H-2d/d F1 males developed SLE as severe as H-2b/b and H-2d/b F1 males. These data indicate that (a) the conventional H-2b is a haplotype leading to susceptibility for murine SLE, while H-2d is a relatively resistant haplotype; (b) the H-2b haplotype exhibits a dominant effect on autoimmune responses, similar to the classical MHC-linked Ir gene effect; and (c) most strikingly, the Yaa gene totally abrogates the MHC effect on murine lupus in (NZB x BXSB)F1 hybrid mice.
A NEW APPARATUS FOR ADMINISTERING ANESTHETICS.
Authors: EDMOND SOUCHON
Journal: JAMA (1894)

THE ANESTHETIZER. This new apparatus has for its object to<i>force the vapor alone</i>of anesthetics into the pharynx through a tube passed into the nose or mouth, or to force the vapor into a cone. I call this apparatus by the newly coined word, "anesthetizer," because such a device requires really a new word to express its mode of action, which is active since the vapor is<i>forced</i>out of the receptacle into the patient by an agent which is outside of the patient, who is himself passive; whereas inhalers are passive and require the exposure to the air of the anesthetic for their proper working, and require also an active coöperation from the patient. The apparatus consists of a receptacle or bottle of suitable size with a stopper traversed by two tubes, an inlet and an outlet tube,<i>neither of which dips into the liquid anesthetic, but both</i>
Lentiviral shRNA silencing of murine bone marrow cell CCR2 leads to persistent knockdown of CCR2 function in vivo
Authors: Ilze Bot, Jian Guo, Miranda Van Eck, Peter J. Van Santbrink, Pieter H. E. Groot, Reeni B. Hildebrand, Jurgen Seppen, Theo J. C. Van Berkel, Erik A. L. Biessen
Journal: Blood (2005)
RAPID LABORATORY TEST FOR PREGNANCY
Authors: G. H. Dodds
Journal: BMJ (1931)

PREGNANCY MTEDBIJrTNSAThree cases were reported last year, and I here present another case, the youngest yet on record, the patient being only 13 days old at death. HISTORY OF THE CASEA male baby, born on September 19th, 1930, was admitted on October 1st on account of haemoptvsis.He was a full- time baby, and only weighed 2,950 grams, and had been fed on Nestle's milk, supplementary to the breast.When admitted he was slightly cyanosed, and twenty hours after admission had.a profuse nasal haemorrhage of bright red and frothy blood, and died almost immediately (October 2nd).The post-mortem findings were as followvs.The urachus contained a little pus just within the umbilicus.The trachea and bronchi contained frothy blood, the lining walls being normal.The lower lobes of both lungs showed numerous peripheral areas of consolidation, dark red, almost black, well defilled, and raised above the.surface of the aerated lung.The upper lobes were aerated, but had a few discrete areas-
Temperature-dependency of nifedipine as a protective agent during cardioplegia in the rat
Authors: M. FUKUNAMI, D. J HEARSE
Journal: Cardiovascular Research (1985)

An isolated working rat heart preparation was used to characterise the temperature-dependency of the anti-ischaemic properties of nifedipine. In this study hearts were subjected to pre-ischaemic infusion with the St Thomas' cardioplegic solution with or without added nifedipine (0.075 mumol X litre-1). Hearts were then rendered globally ischaemic for various periods, (35, 42, 48, 56, 55, 65, 80, 105 or 130 min) at various temperatures (37.0, 35.5, 34.0, 32.5, 31.0, 29.0, 27.0, 24.0 or 20.0 degrees C, respectively). The duration of ischaemia at each temperature was selected to produce a post-ischaemic (37 degrees C) recovery of aortic flow that was approximately 50% of its pre-ischaemic (37 degrees C) control. In addition to functional indices (aortic flow, cardiac output, coronary flow, aortic pressure and heart rate) creatine kinase leakage during reperfusion was measured. At all temperatures at or above 31 degrees C the addition of nifedipine enhanced significantly (maximal value = 43%) the post-ischaemic recovery of aortic flow and other indices of pump function, while at the same time reducing significantly (by up to 56%) enzyme leakage. At ischaemic temperatures below 31 degrees C nifedipine failed to afford any significant additional protection when assessed functionally or enzymatically. It would therefore appear that hypothermia either blocks the action of nifedipine or, by acting on some common mechanism, renders the actions of the drug redundant.
INNERVATION OF SWEAT GLANDS IN HORSES AND DOGS
Authors: MARY BELL, WILLIAM MONTAGNA
Journal: British Journal of Dermatology (1972)

Summary.— The sweat glands in the digital pads of dogs are surrounded by nerves that are clearly demonstrated with techniques for acetyl‐ and butyryl‐cholinesterase. The glands in the hairy skin have no such nerves. In the horse, despite some variation in the abundance of demonstrable nerves around the glands, the latter are surrounded by nerves that are demonstrated only with techniques for acetylcholinesterase.
The Effect of Corticotropin on the Antral Phase of Gastric Secretion
Authors: Demetre M. Nicoloff, E. T. Peter, Raymond C. Doberneck, Nelson H. Stone, Owen H. Wangensteen
Journal: JAMA (1963)

IN RECENT YEARS there has been increasing interest in the hormonal aspects of peptic ulcer. Numerous reports of peptic ulcer associated with polyendocrine disease have appeared in the literature.<sup>1,2</sup>In addition, the availability of various purified hormones for administration to patients has been accompanied by case reports of peptic ulcer reactivation or formation during their administration. The hormones most frequently associated with peptic ulceration are cortisone and corticotropin. Since these hormones are available in a pure state, it is possible to determine their effect on various body functions in both the experimental animal and the patient. Case reports of peptic ulcer formation in patients receiving corticotropin or cortisone would seem to support the concept that stress and anxiety play an important role in the development of acute and chronic peptic ulcers.<sup>3-5</sup>The exact mechanisms that are responsible for this relationship are poorly understood. Whether the peptic ulcers
CHANGES IN THE FATTY ACID COMPOSITION OF THE PHOSPHOLIPIDS, TRIGLYCERIDES AND FREE FATTY ACIDS WITH DEPTH IN THE COW SNOUT EPIDERMIS
Authors: V. J. W. LONG
Journal: British Journal of Dermatology (1972)

Journal Article CHANGES IN THE FATTY ACID COMPOSITION OF THE PHOSPHOLIPIDS, TRIGLYCERIDES AND FREE FATTY ACIDS WITH DEPTH IN THE COW SNOUT EPIDERMIS Get access V. J. W. LONG V. J. W. LONG Medical Research Council Unit on the Experimental Pathology of Skin, The Medical School, The University, Birmingham 15, England Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 87, Issue 3, 1 September 1972, Pages 227–234, https://doi.org/10.1111/j.1365-2133.1972.tb00310.x Published: 01 September 1972 Article history Accepted: 12 April 1972 Published: 01 September 1972
Doctors' leaders urge government to amend commissioning regulations
Authors: C. Dyer
Journal: BMJ (2013)

Doctors’ and nurses’ leaders are urging the government to amend controversial regulations on commissioning NHS health services in England amid fears that they could require competitive tendering for most services.

The BMA and the Royal College of Nursing called on the government on 28 March to take urgent action to clarify the uncertainty, just days before the new “section 75” rules come into force on 1 April, amid the biggest shakeup of the NHS for a generation.

John Ashton, president elect of the UK Faculty of Public Health, and 33 other senior public health specialists have written to Stephen Dorrell, chairman of the parliamentary health select committee, expressing concern that the …
Abstract 786: CEACAM1 regulates myeloid-cell-dependent tumor angiogenesis by inhibition of G-CSFR-Bv8 pathway
Authors: Rongze Lu, John Shively
Journal: Cancer Research (2011)

Abstract Gr1+CD11b+ myeloid cells promote tumor angiogenesis and are refractory to VEGF antibodies treatment. Bv8, also known as Prokineticin 2, expressed in Gr1+CD11b+ cells and positively regulated by granulocyte colony-stimulating factor (G-CSF), has recently been shown to modulate Gr1+CD11b+ cells mobilization and tumor angiogenesis. Anti-Bv8 treatment reduced angiogenesis and growth. However, the signaling pathways in Gr1+CD11b+ to promote tumor angiogenesis are not fully understood. Carcinoembryonic antigen-related cell adhesion moclecule-1(CEACAM1) is highly expressed on Gr1+ myeloid cells, however the role of CEACAM1 in myeloid cells mediated tumor angiogenesis has not been investigated. We have demonstrated that tumor growth and angiogenesis was significantly enhanced in Ceacam1−/− mice, which was independent on T and B cells by backcrossing Ceacam1−/− mice with Rag1−/− mice. Meanwhile Gr1+CD11b+ cells infiltration in tumor, spleen and blood was increased. Tumors coinjected with Gr1+CD11b+ cells from Ceacam1−/− mice exhibited increased angiogenesis compared to coinjection with Gr1+CD11b+ cells from control mice. Depletion of Gr1+ cells inhibited tumor growth and angiogenesis in control and Ceacam1−/− mice. Gr1+CD11b+ cells from Ceacam1−/− mice expressed much higher Bv8 in vitro and in vivo. Further we have shown that CEACAM1 recruited Src-homology-phosphatase-1 (SHP-1) to attenuate granulocyte colony-stimulating factor receptor (G-CSFR)-Bv8 pathway in myeloid cells. Reconsititution of CEACAM1 into Ceacam1−/− bone marrow cells restored tumor growth and angiogenesis to normal level, and mutations of immunoreceptor tyrosine-based inhibitory motifs ITIMs abolished this restoration. Therefore, we identified CEACAM1, as an inhibitory regulator of G-CSFR-Bv8 pathway, negatively regulates myeloid cells dependent tumor angiogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 786. doi:10.1158/1538-7445.AM2011-786
Nicotinic acid test in the diagnosis of Gilbert's syndrome: correlation with bilirubin clearance.
Authors: W Rollinghoff, G Paumgartner, R Preisig
Journal: Gut (1981)

A provocation test with nicotinic acid (50 mg intravenously) was performed in 13 patients with Gilbert's syndrome and seven healthy volunteers to investigate the diagnostic value of several test parameters and to correlate them with the bilirubin clearance. The maximal increment of unconjugated serum bilirubin, the retention at four hours, and the area under the bilirubin concentration time curve. (AUC) were measured. Significant differences between patients and controls were found with regard to the AUC (7.95 +/- SD, 3.29 mmol/min/l vs. 3.08 +/- 0.57; P less than 0.001), the increment of unconjugated bilirubin (24.1 +/- 7.1 mumol/l vs. 10.2 +/- 3.2; P less than 0.001) and the retention (77.7 +/- 8.9% vs. 45.8 +/- 27.4%; P less than 0.02). Of those, the AUC discriminated best between patients and controls. Five patients with Gilbert's syndrome had normal serum bilirubin concentrations (less than 17.1 mumol/l = 1 mg%) at the time of the study, but abnormal AUC and bilirubin increment. A significant correlation was found between the bilirubin clearance and the retention (r = -0.96; P less than 0.001) as well as the AUC (r = -0.82; P less than 0.05) but not with the bilirubin increment. This simple test may be used to assess the disturbance of bilirubin clearance in Gilbert's syndrome.
Left Ventricular Function, Twist, and Recoil After Mitral Valve Replacement
Authors: Abe DeAnda, Masashi Komeda, Srdjan D. Nikolic, George T. Daughters, Neil B. Ingels, D. Craig Miller
Journal: Circulation (1995)

Background Preservation of the mitral subvalvular apparatus during mitral valve replacement (MVR) has become more popular, in part because of the clinically and experimentally demonstrated more optimal left ventricular (LV) performance after surgery; the mechanisms responsible for this beneficial influence, however, have not been clearly elucidated. Methods and Results Fourteen dogs underwent placement of 26 myocardial markers into the LV and septum. One week later, the animals were studied while awake, sedated, and atrially paced (120 beats per minute) both under baseline conditions and after inotropic stimulation (calcium). The animals then underwent MVR and were randomized into either chord-sparing (MVR-Intact) or chord-severing (MVR-Cut) techniques. Two weeks later, the animals were studied under the same conditions. LV systolic function was assessed by the slope of the end-systolic pressure-volume relation (E es ); early LV diastolic filling was analyzed by the pressure-time constant of relaxation (τ). The instantaneous longitudinal gradient of torsional deformation for the LV (twist) was also calculated, as were the changes in twist with respect to time during systole and early diastole (LV recoil). Intergroup comparison showed a trend toward increased contractility (E es , P =.061, before versus after MVR), as well as faster relaxation for the MVR-Intact group. Concurrent analysis of LV systolic function and the rate of systolic twist revealed a significant inverse relation, which disappeared after MVR when the chordae were severed. Conclusions These observations suggest that the mitral subvalvular apparatus acts as a modulator of LV systolic torsional deformation into LV pump (or ejection) performance.
Exit the tie
Authors: T. Greenhalgh
Journal: BMJ (2009)

The other day I had a call from St Cuthbert’s prep school. “Come quickly, doctor, Soames has collapsed.” I rushed round to find the spluttering boy on the floor of the dormitory. From his purple face and distended jugular veins, the diagnosis was clear: overtightened school tie syndrome.

Stopping only to capture the scene on my iPhone to illustrate an article I was planning to submit to Cases journal, I pulled out my scalpel, and with a single swift movement …
Try public health measures in Africa too
Authors: F. I D Konotey-Ahulu
Journal: BMJ (2009)

Salmonella dublin is an important bovine pathogen, causing dysentery, abortion, and death from septicaemia. S dublin dermatitis, a little-recognised occupational hazard for veterinary surgeons, does not cause serious disability or inconvenience. During a survey of brucellosis in south-west Wales four cases of S dublin dermatitis were seen in veterinary surgeons. One surgeon was reinfected three years later. On all five occasions the veterinary surgeons had not worn or had discarded polyethylene gloves. An apparently healthy cow may serve as a latent carrier of S dublin. Thus when disease starts in a closed, protected herd reactivation of infection within the herd is usually blamed and its introduction by extraneous agents considered to be unlikely. Veterinary surgeons should be regarded as potential vectors of S dublin.
Edoxaban: An Update on the New Oral Direct Factor Xa Inhibitor
Authors: Henri Bounameaux, A. John Camm
Journal: Drugs (2014)

Edoxaban is a once-daily oral anticoagulant that rapidly and selectively inhibits factor Xa in a concentration-dependent manner. This review describes the extensive clinical development program of edoxaban, including phase III studies in patients with non-valvular atrial fibrillation (NVAF) and symptomatic venous thromboembolism (VTE). The ENGAGE AF-TIMI 48 study (N = 21,105; mean CHADS2 score 2.8) compared edoxaban 60 mg once daily (high-dose regimen) and edoxaban 30 mg once daily (low-dose regimen) with dose-adjusted warfarin [international normalized ratio (INR) 2.0–3.0] and found that both regimens were non-inferior to warfarin in the prevention of stroke and systemic embolism in patients with NVAF. Both edoxaban regimens also provided significant reductions in the risk of hemorrhagic stroke, cardiovascular mortality, major bleeding and intracranial bleeding. The Hokusai-VTE study (N = 8,292) in patients with symptomatic VTE had a flexible treatment duration of 3–12 months and found that following initial heparin, edoxaban 60 mg once daily was non-inferior to dose-adjusted warfarin (INR 2.0–3.0) for the prevention of recurrent VTE, and also had a significantly lower risk of bleeding events. Both studies randomized patients at moderate-to-high risk of thromboembolic events and were further designed to simulate routine clinical practice as much as possible, with edoxaban dose reduction (halving dose) at randomisation or during the study if required, a frequently monitored and well-controlled warfarin group, a well-monitored transition period at study end and a flexible treatment duration in Hokusai-VTE. Given the phase III results obtained, once-daily edoxaban may soon be a key addition to the range of antithrombotic treatment options.
An HIV Vaccine — Challenges and Prospects
Authors: Margaret I. Johnston, Anthony S. Fauci
Journal: New England Journal of Medicine (2008)

An HIV vaccine has thus far been elusive. Drs. Margaret Johnston and Anthony Fauci remain cautiously optimistic that a substantial increase in our understanding of HIV infection and disease will lead to creative ideas about how to design an effective HIV vaccine. Dr. Anthony Fauci discusses the 30-year search for an HIV vaccine, recent setbacks, and prospects for future success. Dr. Fauci is the director of the National Institute of Allergy and Infectious Diseases, Bethesda, MD.
Nonpharmacological Lipoprotein Apheresis Reduces Arterial Inflammation in Familial Hypercholesterolemia
Authors: Diederik F. van Wijk, Barbara Sjouke, Amparo Figueroa, Hamed Emami, Fleur M. van der Valk, Megan H. MacNabb, Linda C. Hemphill, Dominik M. Schulte, Marion G. Koopman, Mark E. Lobatto, Hein J. Verberne, Zahi A. Fayad, John J.P. Kastelein, Willem J.M. Mulder, G. Kees Hovingh, Ahmed Tawakol, Erik S.G. Stroes
Journal: Journal of the American College of Cardiology (2014)
Management of Ground-Glass Opacity Lesions Detected in Patients with Otherwise Operable Non-small Cell Lung Cancer
Authors: Hong Kwan Kim, Yong Soo Choi, Kwhanmien Kim, Young Mog Shim, Sun Young Jeong, Kyung Soo Lee, O Jung Kwon, Jhingook Kim
Journal: Journal of Thoracic Oncology (2009)