tbuckley/cabot-search huggingface dataset:
Work Prescription
Authors: William F. Hickey, Dorothy A. Oates, Simon S. Olshansky
Journal: New England Journal of Medicine (1954)

THE phrase "light work," used so often by physicians to a patient or to his family or included in reports to insurance companies or welfare agencies, has little meaning by itself.All work requires nearly maximal effort and in employment to-day every worker, whether bookkeeper or longshoreman, is expected to deliver a full day's work to the limit of his abilities. To the partially paralyzed or the cardiac patient, even getting to and from work may be arduous although the work itself may be "light." To the psychoneurotic or the anxiety-ridden person intense concentration may be more difficult than a . . .
Expert Guide to Allergy and Immunology
Authors: John J. Condemi
Journal: Annals of Internal Medicine (2000)

Medical Writings: Book Notes18 April 2000Expert Guide to Allergy and ImmunologyJohn J. Condemi, MDJohn J. Condemi, MDAllergy, Asthma, Immunology of Rochester, P.C., Rochester, New York. (Condemi)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-8-200004180-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Slavin RG, Reisman RE. 236 pages. Philadelphia: American Coll of Physicians; 1999. $35.00. ISBN 09431266738. Order phone 800-523-1546, ext. 2600.Field of medicine: Allergy and immunology.Format: Softcover book.Audience: Primary care physicians.Purpose: To present an efficient, cost-effective approach to diagnosis and management of the allergic and immunologic diseases encountered by the primary care physician.Content: Ten well-organized chapters cover common allergic conditions seen by the primary care practitioner, such as allergic rhinitis, bronchial asthma, and allergic skin diseases. Clear, useful information is given on diagnostic testing and allergy immunotherapy, topics with which most primary care physicians are unfamiliar. ... Author, Article, and Disclosure InformationAffiliations: Allergy, Asthma, Immunology of Rochester, P.C., Rochester, New York. (Condemi) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedical journals’ conflicts of interest in the publication of book reviews 18 April 2000Volume 132, Issue 8Page: 683KeywordsAllergic diseasesAllergic rhinitisAllergy and immunologyAsthmaImmunologyLungsPrimary care physiciansRheumatologySkin diseasesSoftware tools ePublished: 15 August 2000 Issue Published: 18 April 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Intestinal pseudo-obstruction in alcohol abuse: report of two cases.
Authors: J Karani, D Veale, M O Rake
Journal: BMJ (1979)

evidence that there is an increasing demand for this technique, especially in the field of selective breeding. 8 9The uses to which amniocentesis may be put are wider than the medical purposes for which it was originally devised.10In this case the decision taken was one where the general practitioner's suggestions carried no more weight than the woman's own request.Yet medically he had a much deeper knowledge of her circumstances and whether or not the pregnancy was desirable or not.Although women are increasingly applying pressure for termi- nation for social rather than medical reasons, the final decision for abortion is a medical one alone.In the last decade a more liberal" attitude has been apparent, and perhaps this patient's request was just ahead of its time.Nevertheless, it does raise the issue of abortion on demand with all its ethical and social implications, and the legal rights of all concerned.12
High lipoprotein(a) levels and small apolipoprotein(a) sizes are associated with endothelial dysfunction in a multiethnic cohort
Authors: Henry D. Wu, Lars Berglund, Clarito Dimayuga, Jeffery Jones, Robert R. Sciacca, Marco R. Di Tullio, Shunichi Homma
Journal: Journal of the American College of Cardiology (2004)
Cardiac Auscultation Skills of Physicians in Training
Authors: Tsung O. Cheng
Journal: JAMA (1997)

<h3>To the Editor.</h3> —I read with sadness about the waning skills of cardiac auscultation among medical trainees as reported by Drs Mangione and Nieman.<sup>1</sup>The stethoscope, one of medicine's bedrock diagnostic instruments, was invented nearly 180 years ago by Laënnec, who, because he was too shy to put his ear to the chest of a woman patient, rolled a piece of cardboard into a cylinder instead and was so astonished by the chest sounds he could hear that he soon published a book on his findings.<sup>2</sup> The use of a stethoscope is an art of medicine that is being lost amid growing reliance on laboratory tests and computerized imaging equipment. The instrument weighs less than a pound; does not need an electrical outlet, a cardiac catheter, or a video recorder; is not radioactive; has no adverse effects; and fits easily into a coat pocket. It is one of the most effective ways of detecting important medical problems or giving instantaneous assurance to patients with worrisome, yet insignificant, symptoms. The findings of Mangione and Nieman are particularly disturbing as the increase of managed care and ambulatory-based medicine shifts more responsibility for diagnosis and treatment of some diseases onto the shoulders of internists and primary care physicians.
HB F‐Yamaguchi (γ75THR, γ80ASN, γ136ALA) is associated with <sup>G</sup>γ‐thalassemia
Authors: T. Nakatsuji, Y. Ohba, T. H. J. Huisman
Journal: American Journal of Hematology (1984)

Abstract Restriction endonuclease analyses of DNA from a known Hb F‐Yamaguchi heterozygote and three of his relatives have shown a deletion of about 5 kb, which includes one of the γ genes. This abnormality is similar to the G γ‐thalassemia described recently [4] and is probably caused by an unequal crossing over between ‐ G γ‐ and ‐ A γ T ‐genes. The abnormal ‐ G γ A γ T‐X ‐ (X = Asp→Asn at γ80) hybrid gene produces the γ‐Yamaguchi chain at a level usually seen for G γ chains only.
83 THE NEW CONSENSUS DEFINITION OF ACUTE KIDNEY INJURY IS VALID IN PREDICTING MORTALITY IN HOSPITALIZED INFECTED CIRRHOTIC PATIENTS: THE NACSELD EXPERIENCE
Authors: F. Wong, J.G. O'leary, K.R. Reddy, H. Patton, P.S. Kamath, M.B. Fallon, G. Garcia-Tsao, R.M. Subramanian, B. Maliakkal, L.R. Thacker, J.S. Bajaj
Journal: Journal of Hepatology (2013)
Direct and Reflex Effects of Hypoxia on the Systemic Venous and Arterial Beds and Myocardial Contractile Force.
Authors: E. Braunwald
Journal: Annals of Internal Medicine (1962)

s1 April 1962Direct and Reflex Effects of Hypoxia on the Systemic Venous and Arterial Beds and Myocardial Contractile Force.E. Braunwald, M.D. (Assoc.), R. L. Kahler, M.D., L. KedesE. Braunwald, M.D. (Assoc.)Search for more papers by this author, R. L. Kahler, M.D.Search for more papers by this author, L. KedesSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-666_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe circulatory effects of lowering arterial oxygen saturation were studied in a total of 20 dogs on total cardiopulmonary bypass, in a manner permitting the independent assessment of these stimuli on the arterial bed, the venous bed, and the myocardium. The role of the chemoreceptors in the mediation of these responses was investigated by hemodynamically isolating or denervating these structures in 11 dogs.Generalized systemic hypoxia resulted in striking venoconstriction. This effect could be prevented by chemoreceptor denervation, indicating that it was mediated by the chemoreceptor reflex arc. An increase in systemic vascular resistance occurred when hypoxemia was limited to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: E. Braunwald, M.D. (Assoc.); R. L. Kahler, M.D.; L. KedesAffiliations: Bethesda, Md. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 666-666KeywordsCardiopulmonary bypassDenervationHypoxiaMyocardiumOxygenReflexesSystemic vascular resistance ePublished: 1 December 2008 Issue Published: 1 April 1962 PDF downloadLoading ...
Stemming the Global Trade in Falsified and Substandard Medicines
Authors: Lawrence O. Gostin, Gillian J. Buckley, Patrick W. Kelley
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rules and similarity – a false dichotomy
Authors: James A. Hampton
Journal: Behavioral and Brain Sciences (2005)

Unless restricted to explicitly held, sharable beliefs that control and justify a person's behavior, the notion of a rule has little value as an explanatory concept. Similarity-based processing is a general characteristic of the mind-world interface where internal processes (including explicitly represented rules) act on the external world. The distinction between rules and similarity is therefore misconceived.
A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy
Authors: Kerstin Pohl, Elaine Hayes, Joanne Keenan, Michael Henry, Paula Meleady, Kevin Molloy, Bakr Jundi, David A. Bergin, Cormac McCarthy, Oliver J. McElvaney, Michelle M. White, Martin Clynes, Emer P. Reeves, Noel G. McElvaney
Journal: Blood (2014)
Chronic diarrhoea-author's response
Authors: Sanjay Gupta
Journal: Journal of the Royal Society of Medicine (2007)

I thank Mr Marston for his comments regarding our article (JRSM 2007;100: 379).1 He raises two issues. Regarding the first, I agree that the patient may have been saved from all the invasive investigations if the thyromegaly and cervical lymph node enlargement had been identified earlier. I can only surmise that the clinical findings in the neck were not present or were subtle at the time of initial assessment. This case highlights the point that general physical examination of a patient provides vital clues to the diagnosis—a fact that is sometimes overlooked. It is our responsibility to emphasize the importance of this to the next generation of clinicians.

As for the second point, the causes of chronic diarrhoea were taken from a reputable peer-reviewed journal (Gut).2 Ischaemia of the gut has been given different nomenclatures, including mesenteric ischaemia, gut ischaemia, bowel ischaemia and intestinal ischaemia. There is evidence that colonic ischaemia can present as chronic colitis, with endoscopy changes mimicking those seen in inflammatory bowel disease. In most cases, no cause is found and the episodes are considered to be due to localized non-occlusive ischaemia, perhaps due to small vessel disease.3

Mesenteric atherosclerosis can cause chronic mesenteric ischaemia (intestinal angina) where patients present with post-prandial abdominal pain, nausea, bloating and episodic diarrhoea. Malabsorption or constipation can occur. Objective evidence of ischaemia to small bowel causing these symptoms is difficult to obtain. However, focal segmental necrosis of the small bowel can cause symptoms indistinct from Crohn's disease.3 There is a case report of small bowel ischaemic necrosis diagnosed by video capsule endoscopy.4 This investigation and double balloon enteroscopy may shed more light on the pathophysiological changes that occur in the small bowel secondary to mesenteric ischaemia.
STATISTICAL STUDIES OF DIABETES
Authors: James Raglan Miller
Journal: JAMA (1933)

<h3>To the Editor:</h3> —I have recently come across some interesting figures, which throw light on the value of statistical studies based solely on official mortality figures. Godias J. Drolet inThe Journal, March 11, reported diabetes mortality in New York City during the thirty year period 1901-1931. The curves which he showed apparently proved an increase in the number of females as opposed to males, in whom diabetes is given as the primary cause of death. I obtained from Mr. Drolet the original figures reported by the New York department of health and have compared them with the figures which are officially reported by the Census Bureau for New York City. Mr. Drolet in the New York<i>Times</i>of May 21 states that he understands that the local practice in the New York City department of health, where several associated causes of death have been listed, has been to give
Medicine in Cambodian Refugee Camps
Authors: Christopher Elias, Vincent Iacopino
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 March 1987Medicine in Cambodian Refugee CampsCHRISTOPHER ELIAS, M.D., VINCENT IACOPINO, M.D., Ph.D.CHRISTOPHER ELIAS, M.D.Search for more papers by this author, VINCENT IACOPINO, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-3-482_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent article by Drs. Soffer and Wilde ( 1 ) concerning medical relief efforts at the Thai-Kampuchean border was read with interest by the medical community here in Aranyaprathet. Unfortunately, it did not provide an accurate picture of the work we do. The vast majority of persons working here are professionals who have made a long-term commitment to this relief effort. Drs. Soffer and Wilde worked in Site 2 for approximately 1 month. Their perspectives and conclusions were clearly influenced by such a short stay.A few updates and corrections are in order. In October 1985...Reference1. SOFFERWILDE AH. Medicine in Cambodian refugee camps. Ann Intern Med. 1986;105:618-21. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHRISTOPHER ELIAS, M.D.; VINCENT IACOPINO, M.D., Ph.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMore on Medicine in Refugee CampsTHOMAS C. JONES, M.D. 1 March 1987Volume 106, Issue 3Page: 482-482KeywordsCyclic adenosine monophosphate ePublished: 1 December 2008 Issue Published: 1 March 1987 PDF downloadLoading ...
Mite elimination ‐ clinical effect on eczema
Authors: P. S. Friedmann, B. B. Tan
Journal: Allergy (1998)

Allergic reactivity to house-dust mites (HDM) can be detected in patients with atopic eczema by prick and patch test challenge. To determine the clinical relevance of this reactivity, we performed a placebo-controlled, double-blind trial of anti-HDM measures. Active treatment comprised Gortex bags for all the bedding elements, a high-powered vacuum cleaner, and a spray containing benzyl alcohol and tannic acid to kill mites and denature allergens. Placebo treatment was light cotton bags, a cheap vacuum cleaner, and water spray. Forty-eight patients (28 active group) completed the trial, which lasted 6 months. Dust was sampled from the mattress surface and bedroom and living-room carpets before and at monthly intervals after institution of the measures. Dust was weighed and Der p 1 determined by ELISA (ALK). Patients were assessed for area and severity of eczema by a blinded observer. There was a highly significant reduction in bed surface dust - most beds yielded insufficient dust to extract and assay. Carpet Der p 1 levels were reduced to similar minimal levels by both active and placebo treatments (about 250 ng/m2). There were highly significant benefits on the eczema scores, the active treatment being greatly superior to placebo (P< or =0.0006; analysis of covariance). In conclusion, Gortex bed bags were highly effective at containing dust within the bed. This was associated with clinical improvement in most patients with atopic eczema - the biggest improvements were seen in the most severely affected subjects.
THE THERAPEUTIC VALUE OF NONSURGICAL DRAINAGE OF THE BILIARY TRACT
Authors: B. B. VINCENT LYON
Journal: JAMA (1925)

During the past decade, a number of noteworthy contributions have furthered the earlier recognition and more rational treatment of certain diseases involving the liver, gallbladder, gall ducts, pancreas and duodenum. Our knowledge of the physiology of the liver, gallbladder and pancreas is becoming more exact, although much remains mazed in speculation. In this paper we aim to emphasize the fact that disease of the gall tract is a manifold and composite disease in which many organs are intimately or remotely involved. For many years, too great emphasis has been laid on the gallbladder as the chief offender. Until recently, we have not clearly enough recognized the concurrent infection and degenerative changes in the liver, bile ducts, pancreas and intestines which often play a prominent rôle in gall tract disease and produce a widely varying digestive complex. To understand the protean nature of gall tract disease, it is important not only
A DEVICE FOR SUSPENDING AN ICEBAG
Authors: Maude L. Lindsey
Journal: JAMA (1926)

In the treatment of heart disease of children, it may be difficult to keep an icebag in place. Its weight in such cases is also an objection. To avoid these difficulties, a device as shown in the illustration has been constructed. The apparatus consists of two slotted wooden beams made stationary at right angles, and an adjustable block and tackle to which the icebag sling and a counterbalance are attached. The upright beam is fastened to the cross rods at the head of the bed by means of two adjustable hooked belts. The horizontal beam carries the adjustable block and tackle which is to be made stationary directly over the point of application of the icebag. The sling is composed of a strong wire ring suspended by means of three adjustable cords, which are held apart by means of a triangular wooden frame, through the corners of which the cords
Early vs Late Administration of Glycoprotein IIb/IIIa Inhibitors in Primary Percutaneous Coronary Intervention of Acute ST-Segment Elevation Myocardial Infarction
Authors: Gilles Montalescot, Maria Borentain, Laurent Payot, Jean Philippe Collet, Daniel Thomas
Journal: JAMA (2004)

ContextGlycoprotein IIb/IIIa (Gp IIb/IIIa) inhibitors improve myocardial reperfusion and clinical outcomes of patients undergoing primary percutaneous coronary intervention (PCI), but optimal timing of administration remains unclear. No systematic reviews have comprehensively examined the effects of early vs delayed administration of these agents.ObjectiveTo perform a meta-analysis of randomized trials of early (prior to transfer to the catheterization laboratory) vs late (at the time of PCI) intravenous administration of Gp IIb/IIIa inhibitors in acute ST-segment elevation myocardial infarction (STEMI).Data SourcesMEDLINE and the Cochrane Controlled Trials Register search of the literature over the past 10 years; papers presented at major cardiac conferences; consultation with national and international colleagues as well as Gp IIb/IIIa inhibitor drug manufacturers; and text and journal article bibliographies.Study Selection and Data ExtractionWe examined trials of randomized comparisons between early administration at the point of initial contact (emergency department or ambulance) and late administration (catheterization laboratory) of Gp IIb/IIIa inhibitors in STEMI. Outcome data had to be available on both culprit artery patency evaluated by Thrombolysis in Myocardial Infarction (TIMI) flow grades on admission and mortality. Two authors independently reviewed abstracts or complete articles. Six studies met inclusion criteria. Independent data extraction was performed by 2 reviewers and confirmed by consensus.Data SynthesisThe 6 trials enrolled 931 STEMI patients treated with abciximab (3 trials) or tirofiban (3 trials) in combination with primary PCI. TIMI grade 2 or 3 flow (41.7% [194/465 vs 29.8% [139/466]) as well as TIMI grade 3 flow (20.3% [84/413] vs 12.2% [51/418]) were significantly more frequent in the early group compared with the late group (odds ratio [OR], 1.69; 95% confidence interval [CI], 1.28-2.22; P<.001; and OR, 1.85; 95% CI, 1.26-2.71; P<.001, respectively). The early administration of Gp IIb/IIIa inhibitors was associated with a 28% reduction of mortality from 4.7% to 3.4%, which was not significant but consistent with similar trends for reinfarction and the composite ischemic end point.ConclusionsIn a meta-analysis of 6 randomized trials, early administration of Gp IIb/IIIa inhibitors in STEMI appeared to improve coronary patency with favorable trends for clinical outcomes. These findings are supportive of a strategy of facilitated PCI. Further evaluations in adequately powered large trials are awaited to confirm the clinical benefit of this strategy.