tbuckley/cabot-search huggingface dataset:
Endothelin pathway and renin-angiotensin system in the progression to isolated diastolic heart failure in hypertensive hearts
Authors: K. Ono, T. Masuyama, K. Yamamoto, R. Doi, T. Mano, H. Kondo, T. Kuzuya, T. Miwa, M. Hori
Journal: Journal of the American College of Cardiology (1998)
Surgery of the Facial Nerve
Authors: Bradford Cannon
Journal: JAMA (1974)

Adolph Miehlke of Göttingen and his collaborators have presented a most exhaustive study of the surgery of the facial nerve. Originally published in German, it was translated by Loren S. Michaelis of London in a most commendable manner. The emotional and social impact of facial paralysis may be quite severe. Yet attempts at restoration of continuity of the facial nerve have only very recently been considered possible. Doubtless, the complex course of the nerve from its origin in the pons to the end plates in the muscles of expression has been a considerable deterrent. Substitute procedures providing a semblance of normal symmetry were all that surgeons could offer. Today the possibilities are quite auspicious. The authors of this book have succeeded in covering essentially all aspects of the surgical problems of the facial nerve. These include its anatomy, the several causes of paralysis, the differential diagnosis of the segment involved,
The exhumation of Mattia Preti, painter.
Authors: V. G. Griffiths
Journal: BMJ (1988)

trated these common features in his own style.We do not suggest that the examples of de Chirico's work discussed here are illustrations of his migraine attacks as are those from the national migraine art competition.Rather, we propose that de Chirico used his experiences of classical migraine as one of the sources of inspiration for his paintings. Hallucinatory inspirationVisual migrainous hallucinations have provided inspiration for others.Charles Dodgson, better known as Lewis Carroll, is known to have suffered from migraine and is thought to have used his migrainous disturbances of body image as inspiration for Alice's Adventures in Wonderland.'0Atkinson and Appenzeller described a patient who had migraine who painted her complex visual hallucinations." Hildegard of Bingen (1098-1180), a nun and mystic, had countless visions that she not only described but also illustrated.Her migraine "visions" have been reviewed by Singer'2 and Sacks.It is of interest in our context that she thought that the visions were of divine origin, as de Chirico too seemed to interpret his as privileged revelations of another reality.The symptoms acknowledged by de Chirico, taken with the evidence from his writings and confirmed by independent contemporary comments, suggest that he suffered from migrainous visual hallucinations.The evidence from some of his prints and paintings, when they are compared with those of other migraineurs, suggests that de Chirico used these hallucinations as a source for some of the more striking details of his work.We thank Mr Derek Robinson of Boehringer Ingelheim for allowing us to see entries to the national migraine art competition and to use figures 2 and 5.
PI3K in hypertension: a novel therapeutic target controlling vascular myogenic tone and target organ damage
Authors: D. Carnevale, G. Lembo
Journal: Cardiovascular Research (2012)

In the past decade, several studies have characterized a number of cellular and molecular mechanisms that contribute to the regulation of the vascular myogenic response, thus affecting blood pressure regulation. Recently, phosphoinositide 3-kinase γ (PI3Kγ) has been identified as a main regulator of vascular myogenic tone and blood pressure, a result further strengthened by a highly significant genome-wide association of a single nucleotide polymorphism flanking this gene with blood pressure regulation, in a large human population. The goal of this review is to summarize the available information regarding the mechanism whereby PI3Kγ exerts blood pressure control, regulating myogenic tone at the level of L-type calcium channel in smooth muscle cells. Moreover, an overview of the pharmacological approaches available for targeting this signalling pathway shows that PI3Kγ is a suitable candidate for antihypertensive therapy, capable of lowering blood pressure. Finally, a survey of the studies dissecting the role of PI3Kγ in pathological conditions that are typically induced by hypertension in its target organs provides a more complete picture of the high potential of this novel therapeutic approach for fighting hypertension and, at the same time, its target organ damage, independently of bloodpressure-lowering effects.
The medical rumour mill
Authors: Des Spence
Journal: BMJ (2007)

I winced as he shoved the cannula down alongside my vein and into the soft tissues of my forearm. “Missed,” he exclaimed, and swore. We were in the common room of the medical residency and practising gaining intravenous access on each other. Despite the beer, it hurt. Only one of our group was remotely competent at practical procedures and was accorded hero status. My pain at least gave me some insight into what it is to be …
Community care for demented and non-demented elderly people: a comparison study of financial burden, service use, and unmet needs in family supporters
Authors: I Philp, K J McKee, P Meldrum, B R Ballinger, M L M Gilhooly, D S Gordon, W J Mutch, J E Whittick
Journal: BMJ (1995)

<h3>Abstract</h3> <b>Objective</b>: To measure and compare perceived financial burden, use of services, and perceived unmet service needs of supporters of demented and non-demented elderly people. <b>Design</b>: Comparison study of age and sex matched demented and non-demented elderly people and their supporters. <b>Setting</b>: 25 primary health care teams in Dundee. <b>Subjects</b>: 114 community resident elderly (age over 65) people with dementia, 114 age and sex matched comparators, and the main informal supporter of each elderly person. <b>Main outcome measures</b>: Carers9 perceptions of financial impact of looking after an old person, service use (from a list of locally available services), unmet service needs, and needs for three types of generic service (help with supervision, housework, or personal care). <b>Results</b>: Financial impact was low, except for extra household expense in the dementia group. There was significantly greater use of mainstream domiciliary and day care services in the dementia group. Dementia was nevertheless associated with a high level of unmet need, mainly for more mainstream support and help with supervision of the elderly person. <b>Conclusion</b>: Supervisory care for demented elderly people should be further developed within an expanded domiciliary service to meet supporters needs. <h3>Key messages</h3> Key messages Community care for demented elderly people is thought to pose special problems for carers but comparison studies with non-demented elderly people are rare The financial impact on family carers of demented elderly people in a Scottish city was not as high as expected The use of mainstream domiciliary and day care services was significantly higher for demented than non-demented elderly people Family carers of demented elderly people need more support in caring for these people
A FURTHER CLINICAL STUDY OF ANABOLIC STEROIDS IN INCONTINENCE
Authors: GEORGE VLAVIANOS, GIDEON SEAMAN, MARIA VLAVIANOS
Journal: American Journal of Psychiatry (1961)

Inability to restrain bodily discharges is a problem of both individual and social concern. In the mental institution the incontinent patient presents a severe nursing problem. After preliminary encouraging results obtained in a previous clinical trial, and confirmed by other authors, a further 33-week clinical study was conducted on 16 male patients with bladder and/or bowel incontinence with a new anabolic steroid (Dianabol). The dramatic results of continence in all 16 patients whose physical and mental resources were of the lowest, encourages us to recommend the anabolic androgensteroids in bladder and bowel incontinence for clinical trials on patients both in and outside the "back wards" of a mental institution. Further studies of the hypothesized pharmacodynamic effect of the anabolic male steroids on the incontinent patient are warranted. These should include physiological experiments, double-blind studies on patients with various physical and mental conditions and causes of incontinence, and studies in different environmental and cultural settings. There should be emphasis on possible psychosociological and placebo factors.
Inconclusive evidence for non-inferior immunogenicity of two- compared with three-dose HPV immunization schedules in preadolescent girls: A systematic review and meta-analysis
Authors: Robine Donken, Mirjam J Knol, Johannes A Bogaards, Fiona R M van der Klis, Chris J L M Meijer, Hester E de Melker
Journal: Journal of Infection (2015)
Recognition of cloned vesicular stomatitis virus internal and external gene products by cytotoxic T lymphocytes.
Authors: J W Yewdell, J R Bennink, M Mackett, L Lefrancois, D S Lyles, B Moss
Journal: The Journal of Experimental Medicine (1986)

It has generally been assumed that most if not all CTL specific for vesicular stomatitis virus (VSV)-infected cells recognize the viral glycoprotein (G), an integral membrane protein abundantly expressed on infected cell surfaces. Using recombinant vaccinia viruses containing copies of cloned VSV genes to examine CTL recognition of VSV, we have confirmed that G is recognized by VSV-specific CTL. More interestingly, however, we have also found that nucleocapsid protein (N), an internal virion protein, can be detected on infected cell surfaces using mAb, and serves as a major target antigen for VSV-specific CTL. In contrast to the highly serotype-specific recognition of G, N is recognized by a major population of CTL able to lyse cells infected with either the Indiana or New Jersey VSV serotypes. Using target cells expressing a cloned MHC class I gene, we could directly show that CTL recognition of N occurs in the context of the MHC Ld molecule.
Inhibition of calcium-independent phospholipase A impairs agonist-induced calcium entry in keratinocytes
Authors: K. Ross, G. Parker, M. Whitaker, N.J. Reynolds
Journal: British Journal of Dermatology (2007)

Journal Article Inhibition of calcium‐independent phospholipase A impairs agonist‐induced calcium entry in keratinocytes Get access K. Ross, K. Ross Dermatological Sciences, Institute of Cellular Medicine, and Institute of Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K. Correspondence: Kehinde Ross. E‐mail: kehinde.ross@newcastle.ac.uk Search for other works by this author on: Oxford Academic Google Scholar G. Parker, G. Parker Dermatological Sciences, Institute of Cellular Medicine, and Institute of Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K. Search for other works by this author on: Oxford Academic Google Scholar M. Whitaker, M. Whitaker Dermatological Sciences, Institute of Cellular Medicine, and Institute of Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K. Search for other works by this author on: Oxford Academic Google Scholar N.J. Reynolds N.J. Reynolds Dermatological Sciences, Institute of Cellular Medicine, and Institute of Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 158, Issue 1, 1 January 2008, Pages 31–37, https://doi.org/10.1111/j.1365-2133.2007.08298.x Published: 01 January 2008
P298 ACETAMINOPHEN (APAP) FORMULATIONS CONTAINING METHYL-SULFONYL-METHANE AND ISOSILYBIN B AMELIORATE APAP-MEDIATED LIVER TOXICITY WHILE RETAINING APAP EFFICACY
Authors: A. Ben Ya'acov, Y. Lichtenstein, Y. Shabat, T. Sobol, Y. Mograbi, Y. Ilan
Journal: Journal of Hepatology (2014)
Clozapine Treatment of Schizophrenia
Authors: David Pickar, John K. Hsiao
Journal: JAMA (1995)

<h3>SELECTED CASE</h3> A 27-year-old woman was admitted to the National Institutes of Health Clinical Center, Bethesda, Md, for inpatient research protocol for schizophrenia. She first experienced behavioral disturbances at 13 years of age when she became withdrawn and isolated from friends and family. She reported auditory hallucinations for the first time at 16 years and developed delusions of control and persecution over ensuing months. Suicidal ruminations culminated in a serious suicide attempt and her first hospitalization at the age of 17 years. Although standard antipsychotic drugs reduced her delusions, the patient remained socially isolated and had symptom exacerbation when under stress. She discontinued antipsychotic drug treatment because of adverse effects on several occasions; in each case, she became acutely psychotic. Prior to her admission to the National Institute of Mental Health, she was hospitalized 15 times, including several hospitalizations mandated by the court because of risk to herself and to
Angiotensin II type 2 receptor gene polymorphism and cardiovascular phenotypes: the GLAECO and GLAOLD studies
Authors: Stefan‐Martin Herrmann, Viviane Nicaud, Klaus Schmidt‐Petersen, Jacqueline Pfeifer, Jeanette Erdmann, Theresa McDonagh, Henry J. Dargie, Martin Paul, Vera Regitz‐Zagrosek
Journal: European Journal of Heart Failure (2002)
Incidental Thallium Uptake in Bilateral Breast Lymphoma During Myocardial Perfusion Scintigram
Authors: Panagiotis Georgoulias, Nikolaos Demakopoulos, Theodora Papadaki, Georgios Ioannidis, Garyfallia Kokkini, Georgios Mortzos
Journal: Clinical Nuclear Medicine (2004)

Development of malignant lymphoma in the female breast as a primary or secondary site from distant lymphoma is rare. The authors present an unusual case of incidental detection of a breast non-Hodgkin lymphoma during T1-201 myocardial perfusion imaging. A 70-year-old woman, who presented with angina, had T1-201 stress–rest thallium single-photon emission computed tomography. Unexpectedly, stress and rest images showed intense uptake of the radiotracer in both breasts, primarily in the right breast. Physical examination revealed a large palpable mass infiltrating most of the right breast and a smaller well-circumscribed mass in the left breast and bilateral axillary lymphadenopathy. X-ray mammography identified one large lesion in the right breast and a smaller mass in the left breast. Biopsy and histologic examination established the diagnosis of a non-Hodgkin lymphoma.
Adapting clinical guidelines to take account of multimorbidity
Authors: B. Guthrie, K. Payne, P. Alderson, M. E. T. McMurdo, S. W. Mercer
Journal: BMJ (2012)

Care of patients with multimorbidity could be improved if new technology is used to bring together guidelines on individual conditions and tailor advice to each patient's circumstances, say <b>Bruce Guthrie and colleagues</b>
Pulmonary Artery Thrombosis during Acute Chest Syndrome in Sickle Cell Disease
Authors: Armand Mekontso Dessap, Jean-François Deux, Nour Abidi, Cécile Lavenu-Bombled, Giovanna Melica, Bertrand Renaud, Bertrand Godeau, Serge Adnot, Laurent Brochard, Christian Brun-Buisson, Frederic Galacteros, Alain Rahmouni, Anoosha Habibi, Bernard Maitre
Journal: American Journal of Respiratory and Critical Care Medicine (2011)

Rationale: The pathophysiology of acute chest syndrome (ACS) in patients with sickle cell disease is complex, and pulmonary artery thrombosis (PT) may contribute to this complication.Objectives: To evaluate the prevalence of PT during ACS using multidetector computed tomography (MDCT).Methods: We screened 125 consecutive patients during 144 ACS episodes. One hundred twenty-one MDCTs (in 103 consecutive patients) were included in the study.Measurements and Main Results: Twenty MDCTs were positive for PT, determining a prevalence of 17% (95% confidence interval, 10–23%). Revised Geneva clinical probability score was similar between patients with PT and those without. D-dimer testing was very often positive (95%) during ACS. A precipitating factor for ACS was less frequently found in patients with PT as compared with those without. Patients with PT exhibited significantly higher platelet counts (517 [273–729] vs. 307 [228–412] 109/L, P < 0.01) and lower bilirubin (28 [19–43] vs. 44 [31–71] μmol/L, P < 0.01) levels at the onset of ACS as compared with others. In addition, patients with PT had a higher platelet count peak (537 [345–785] vs. 417 [330–555] 109/L, P = 0.048) and smaller bilirubin peak (36 [18–51] vs. 46 [32–83] μmol/L, P = 0.048) and lactate dehydrogenase peak (357 [320–704] vs. 604 [442–788] IU/L, P = 0.01) during hospital stay as compared with others.Conclusions: PT is not a rare event in the context of ACS and seems more likely in patients with higher platelet counts and lower hemolytic rate during ACS. Patients with sickle cell disease presenting with respiratory symptoms suggestive of ACS may benefit from evaluation for PT.
Is social psychological research really so negatively biased?
Authors: Aiden P. Gregg, Constantine Sedikides
Journal: Behavioral and Brain Sciences (2004)

Krueger &amp; Funder (K&amp;F) overstate the defects of Null Hypothesis Significance Testing (NHST), and with it the magnitude of negativity bias within social psychology. We argue that replication matters more than NHST, that the pitfalls of NHST are not always or necessarily realized, and that not all biases are harmless offshoots of adaptive mental abilities.
Viral kinetics on treatment with pegylated (PEG 40 KD) interferon (IFN) alfa2a in patients infected with HCV subtype 1
Authors: P. Ferenci, Rudolf Stauber, Franz Hackl, Wolfgang Jessner, Karin Hegenbarth, Petra Munda-Steindl, Harald Kessler
Journal: Journal of Hepatology (2001)
HIV cannot be tackled in isolation
Authors: Peter A West
Journal: BMJ (2006)

Evidence based diagnosis We may need to be open to new ideasEditor-If evidence based diagnosis is still in the dark ages, as Delamothe writes, 1 then so is evidence based treatment.The doctor's job is to choose the right treatment.If the diagnosis is wrong then the treatment will be wrong.Inaccurate diagnoses will also affect clinical trials.A treatment may be "evidence based" because it has worked in a published study, but some patients who would have responded might have been left out because of diagnostic inaccuracy while some patients with no prospect of responding might have been included incorrectly. 2vidence based diagnosis is about convincing others using shared rules of evidence that a diagnosis (and its implications in terms of treatment) should be accepted by others.Evidence is gathered from the individual and from groups of patients. 3Evidence based diagnosis means specifying the individual's facts in addition to pointing to facts relating to that diagnosis in the literature. 4ayes's theorem uses unconditional initial prior probabilities.Diagnostic leads are based on conditional probabilities and are used to initiate diagnostic thought processes. 4owever, closely related theorems can be used to interpret diagnostic leads, which allow doctors to reason with diagnostic evidence in a more familiar way, 3 thus reducing misunderstandings. 5So to improve evidence based diagnosis we also need to collect better data on diagnostic leads.The published evidence given for a diagnosis and any related actions cannot realistically be assembled when actually seeing a patient.A draft evidence based rationale might be prepared in advance.It would have to be capable of being accessed in seconds to provide evidence in support of a suspected diagnosis and decision arrived at by using kindness, imagination, and common sense.It could be put into context by inserting the patient's details into the draft evidence summoned up from a computer.If we are to make progress and allow evidence based diagnosis to emerge from the dark ages then in addition to doing more of the same, we may also have to be receptive to new ideas.
<i>Tropaeolum majus</i>and contact dermatitis
Authors: P.D.L. Maurice
Journal: British Journal of Dermatology (1997)

Journal Article Tropaeolum majus and contact dermatitis Get access P.D.L. Maurice P.D.L. Maurice rtment of Dermatology, St Albans City Hospital, Waverley Road, St Albans, Hertfordshire AL3 5PN, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 137, Issue 4, 1 October 1997, Page 661, https://doi.org/10.1111/j.1365-2133.1997.tb03818.x Published: 01 October 1997
Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model.
Authors: D B West, J Goudey-Lefevre, B York, G E Truett
Journal: Journal of Clinical Investigation (1994)

Loci linked to sensitivity to dietary obesity were identified by Quantitative Trait Locus (QTL) analysis of two mapping populations derived from a cross between AKR/J and SWR/J mice. AKR/J mice are sensitive to dietary obesity when fed a high fat diet while SWR/J mice are resistant. Intercrosses between these strains segregate the phenotype of sensitivity to dietary obesity. Using an F2 mapping population of 931 male mice we found significant linkage with a QTL on chromosome 9 (Likelihood of the Odds [LOD] ratio of 4.85) and another QTL on chromosome 15 (LOD = 3.93). The presence of a QTL on chromosome 15 was confirmed in a separate mapping population of 375 male F1 x SWR/J mice (LOD = 3.82). These two loci are designated dietary obese 2 (Do2) and dietary obese 3 (Do3) for the chromosome 9 and 15 loci, respectively. Both of these chromosomal regions contain candidate genes which may contribute to variation in the phenotype. These loci also exert a significant control over individual adipose depot weights.
Papillary Carcinoma of the Thyroid Seven Years After 1-131 Therapy for Graves?? Disease
Authors: I ROSS McDOUGALL, THOMAS S. NELSEN, RICHARD L. KEMPSON
Journal: Clinical Nuclear Medicine (1981)

A 73-year-old woman was found to have an infiltrating papillary cancer of the thyroid seven years after she received 9.1 mCi of I-131 for treatment of Graves' hyperthyroidism. Details of 25 other cases in the literature are presented. The number of thyroid cancers found in patients previously treated with radioiodine is considerably less than would be anticipated by chance.
An explanation for minor multimer species in endothelial cell-synthesized von Willebrand factor.
Authors: D C Lynch, T S Zimmerman, E H Ling, P J Browning
Journal: Journal of Clinical Investigation (1986)

Initial synthesis of von Willebrand factor (vWf) by cultured human endothelial cells proceeds by formation of a dimer of pro-vWf subunits. These subunits are found only within the cell and have an apparent molecular weight of 240,000-260,000, as measured by electrophoresis in sodium dodecyl sulfate-polyacrylamide gels. Posttranslational modifications, including proteolytic cleavage, glycosylation, and sulfation, result in the appearance of two additional vWf subunits. The major one migrates with the subunit of plasma vWf at an apparent molecular weight of 220,000-225,000 and the other migrates more slowly than pro-vWf at an apparent molecular weight of 260,000-275,000. These subunits oligomerize to form a set of vWf multimers, which are subsequently secreted into the culture medium. We isolated individual vWf oligomer species from the agarose gel bands and show that vWf minor, or satellite, species differ from major species in subunit composition.