tbuckley/cabot-search huggingface dataset:
Osteopaths Are Physicians
Authors: GARY C. GARFIELD
Journal: Annals of Internal Medicine (1975)

To the editor: The editorial "Federal Recognition of Chiropractic: A Double Standard" in the May issue (Ann Intern Med 82:712-713) mentions "The bringing together in one room of 11 Ph.D.'s, 7 osteopaths, 16 chiropractors, and 24 physicians." This seems to imply that osteopaths are not physicians. On the contrary, graduates of osteopathic medical schools deliver complete health care, both as primary physicians and in the medical and surgical specialties and subspecialties. Many osteopathic physicians are trained in AMA-approved postgraduate training programs.
Reply to Eken and Eken
Authors: T. Yoshida, Y. Shimizu, S. Ono, N. Oridate, M. Kato, M. Asaka
Journal: Endoscopy (2009)

We thank Drs. Eken and Eken for their interest in our article and for raising a question about endoscopic submucosal dissection (ESD) for superficial supraglottic squamous cell carcinoma (SCC) at an early stage. They raise interesting points.
Ethics at the <i>BMJ</i>
Authors: Fiona Godlee
Journal: BMJ (2007)

One of the BMJ 's assets is its ethics committee. The committee meets every three months to provide the editor with broad ethical guidance and consider ethical dilemmas arising from articles submitted to and commissioned by the journal. Chaired by Iona Heath (a GP, ethicist, and BMJ columnist ( BMJ 2007;334:341 doi: 10.1136/bmj.39125.448287.59)), its members are appointed after open application and competitive interview. Rather than publishing the minutes of the meeting, which presented problems of confidentiality, we now publish an annual report (http://resources.bmj.com/bmj/about-bmj/ethics-committee).

In the report for 2005 (2006 is coming shortly), Liz Wager describes the issues raised by the year's 11 new cases. Several cases raised the perennial question of what constitutes …
The Edinburgh School of Surgery after Lister
Authors: J. A Ross
Journal: BMJ (1979)

<h3>Background</h3> Many psychotherapy theories emphasise the importance of self-schema and other-schema, but most previous studies focused on the explicit self-schema in major depressive disorder (MDD). However, the limited studies of implicit self-schema in MDD have shown inconsistencies in their findings. Furthermore, only a few studies have investigated the implicit other-schema, and the pathway illustrating how implicit schemas influence depression remains unclear. <h3>Aims</h3> The primary aim of our study was to explore the characteristics of implicit self-schema and other-schema in patients with MDD. We also examine the chain-mediating effect of attachment relationships and interpersonal trust. <h3>Methods</h3> The present study included 88 patients with MDD and 88 healthy controls (HCs). The Hamilton Depression Rating Scale-17, Experiences in Close Relationships Inventory—Revised Questionnaire, Trust Scale and the Extrinsic Affective Simon Task (EAST) were used to assess depressive symptoms, attachment relationships, interpersonal trust and implicit schemas, respectively. Paired sample t-test was used to compare the reaction time (RT) for positive and negative words within the two groups. Analysis of covariance was used to explore the difference between two groups from the perspective of implicit schemas and interpersonal patterns. The chain mediation model was verified by bootstrap. <h3>Results</h3> (1) For interpersonal patterns, patients with MDD scored significantly higher on attachment anxiety (F=82.150, p&lt;0.001) and attachment avoidance (F=23.192, p&lt;0.001) and scored significantly lower on the predictability (F=30.297, p&lt;0.001), dependence (F=39.728, p&lt;0.001) and faith (F=60.997, p&lt;0.001) dimensions of interpersonal trust. (2) As for implicit schemas, no significant difference was found between the RT for positive self-words and negative self-words in patients with MDD (t=−1.056, p=0.294). However, the HC responded faster to positive self-words than negative self-words (t=−3.286, p=0.001). The RT for positive other-words and negative other-words were significantly different in both patients with MDD (t=2.943, p=0.004) and HCs (t=−2.482, p=0.015), with opposite directions. The EAST effect of other-schema in patients with MDD was significantly different from that in HCs (F=13.051, p&lt;0.001). (3) For the total sample, the EAST effect of other-schema significantly correlated with attachment avoidance, interpersonal trust and depressive symptoms. Attachment avoidance and interpersonal trust were the chain mediators between the EAST effect of other-schema and depressive symptoms (95% CI: −0.090 to −0.008). However, no significant results were found for the EAST effect of other-schema when correlation and mediation analyses were performed for HCs and patients with MDD separately. <h3>Conclusions</h3> This study verified that patients with MDD have abnormal interpersonal patterns and negative implicit schemas. However, no mediating effect of attachment relationships and interpersonal trust was found.
The value of B‐type natriuretic peptide and big endothelin‐1 for detection of severe pulmonary hypertension in heart transplant candidates
Authors: Miloš Kubánek, Ivan Málek, Josef Kautzner, Markéta Hegarová, Martin Wiendl, Petr Lupinek, Ludmila Karasová, Věra Lánská
Journal: European Journal of Heart Failure (2005)
Serum Cholesterol and Triglyceride Levels and Adiposity
Authors: B. M. Rifkind, M. Gale, D. Lawson
Journal: Cardiovascular Research (1968)

The positive correlation between serum cholesterol levels and adiposity is shown to be dependent on a common relationship to serum triglyceride levels. It is inferred that serum very low density lipoprotein levels are weight related, but that low density lipoprotein levels are not.
Effects of oxyfedrin: a -adrenoreceptor stimulant, on infarct size following acute coronary artery ligation
Authors: G. TIMOGIANNAKIS, D. PETROPOULOS, P. TOUTOUZAS, C. COUROUKLIS, D. AVGOUSTAKIS
Journal: Cardiovascular Research (1978)

Regional left ventricular blood flow and the extent of myocardial ischaemia were studied after acute coronary artery occlusion in open-chest dogs before and after infusion of oxyfedrin, a beta-adrenergic stimulant. Regional blood flow was measured with radioactive tracer microspheres and local tissue injury was estimated by the S-T segment elevation in epicardial electrocardiograms. Animals receiving oxyfedrin were divided into two groups: 1 and 2. Oxyfedrin was infused intravenously in a dose of 0.80 to 0.94 mg.kg-1 in dogs of group 1 and 1.45 to 1.60 mg.kg-1 in dogs of group 2. The rate of infusion in the animals of both groups was 0.61 mg.min-1. Oxyfedrin caused further S-T segment elevation over ischaemic myocardium and increased the extent of ischaemic injury in group 1 dogs. Conversely, in this same group of dogs, the blood flow was unchanged in low flow regions ( less than 0.3 cm3.g-1.min-1) and increased in higher flow areas, inside the ischaemic region. In the animals of group 2, oxyfedrin caused further S-T segment elevation over ischaemic myocardium and increased the extent of ischaemic injury. Concomitantly, blood flow was significantly reduced both inside and outside the ischaemic region. These observations in dogs of group 1 (ie increased blood flow inside the ischaemic region by infusion of oxyfedrin, in flow zones higher than 0.3 cm3.g-1.min-1, with a further S-T segment elevation over ischaemic myocardium, and an increase in the extent of ischaemic injury) may be explained by a primary effect of oxyfedrin on oxygen demands with secondary changes in blood flow.
G. H. RITTERMAN
Authors: J. Morgan
Journal: British Journal of Dermatology (1972)

Journal Article G. H. RITTERMAN Get access J. Morgan J. Morgan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 87, Issue 3, 1 September 1972, Page 287, https://doi.org/10.1111/j.1365-2133.1972.tb00323.x Published: 01 September 1972
948–53 A New Natriuretic Factor Acting Like Loop Diuretic Drugs in Heart Failure. Relation to the Severity of Left Ventricular Dysfunction
Authors: Jean-Luc Dubois-Randé, Olivier Montagne, Miriam Alvarez, Corinne Nazaret, Bertrand Crozatier, Pascal Gueret, Alain Castaigne, Ricardo Garay
Journal: Journal of the American College of Cardiology (1995)
Pure pancreatic juice studies in normal subjects and patients with chronic pancreatitis
Authors: M. E. Denyer, P. B. Cotton
Journal: Gut (1979)

Pure pancreatic juice was obtained from within the pancreatic duct in 54 patients after endoscopic cannulation of the papilla of Vater. In all 20 normal subjects there was a brisk response to intravenous injections of GIH secretin in small dosage (1 and 4 CU). Peak bicarbonate concentrations occurred after a 4 CU stimulus, whereas volumes, and bicarbonate and protein outputs were greatest after 70 CU. Total protein and amylase concentrations were highest in the first specimens collected from each patient, and fell rapidly after stimulation. Plateau levels for all indices were achieved 10-20 minutes after starting infusions of secretin and pancreozymin. When normal patients and those with chronic pancreatitis were compared, there was considerable overlap in all indices (volume, bicarbonate and total protein concentrations) after bolus injections of secretin. Most patients with chronic pancreatitis achieved a peak bicarbonate concentration in excess of 100 mmol/l. The median concentrations were not significantly different from normal after any dose of secretin when pooled 10 minute samples were analysed. However there were significant differences in peak bicarbonate concentrations (after 1 and 4 CU, but not after 70 CU), when one minute samples were compared. There were also statistically significant differences in the median 10 minute responses for volume after 1 and 70 CU, for bicarbonate output after 1, 4, and 70 CU, and for protein output after 70 CU. The results of juice studies in patients believed to have early chronic pancreatitis did not differ significantly from those in normal subjects or those with chronic pancreatitis. Endoscopic duct cannulation cannot guarantee complete recovery of pancreatic secretions, and measurements of volume and output may be inaccurate. When standard biochemical indices are used, the diagnostic role of pure juice studies is limited; further research may reveal more specific disease markers.
Hepatocellular peroxisomes in human alcoholic and drug-induced hepatitis: A quantitative study
Authors: Dirk de Craemer, Ingrid Kerckaert, Frank Roels
Journal: Hepatology (1991)

The peroxisomes in the liver of four patients with alcoholic hepatitis and in six patients with druginduced hepatitis are compared to eight control livers by catalase cytochemistry and morphometry. A decrease of catalase activity is observed in alcoholic, amitriptyline, aprindine, clomipramine and methimazole hepatitis. Peroxisomes with a heterogeneous distribution of the catalase reaction product are found in most hepatitis livers. The number of organelles is increased 1.5 to 4.2 times in alcoholic, aprindine, methimazole and phenytoin hepatitis livers. In the last case, peroxisomes are also smaller. Changes in shape are seen in all hepatitis livers; they include invaginations, tails, funnel-like constrictions and gastruloid cisternae. In aprindine, phenytoin, methimazole and two alcoholic hepatitis livers, surface density exceeds the upper control value. These data indicate a loss of catalase activity in most hepatitis livers but also peroxisomal proliferation and shape modifications. It has been proposed that the latter changes are favorable for metabolic activity. (HEPATOLOGY 1991;14:811–817).
Mutational spectrum in congenital dyserythropoietic anemia type II: Identification of 19 novel variants in <i>SEC23B</i> gene
Authors: Roberta Russo, Maria Rosaria Esposito, Roberta Asci, Antonella Gambale, Silverio Perrotta, Ugo Ramenghi, Gian Luca Forni, Vedat Uygun, Jean Delaunay, Achille Iolascon
Journal: American Journal of Hematology (2010)

SEC23B gene encodes an essential component of the coat protein complex II (COPII)-coated vesicles. Mutations in this gene cause the vast majority the congenital dyserythropoietic anemia Type II (CDA II), a rare disorder resulting from impaired erythropoiesis. Here, we investigated 28 CDA II patients from 21 unrelated families enrolled in the CDA II International Registry. Overall, we found 19 novel variants [c.2270 A>C p.H757P; c.2149-2 A>G; c.1109+1 G>A; c.387(delG) p.L129LfsX26; c.1858 A>G p.M620V; c.1832 G>C p.R611P; c.1735 T>A p.Y579N; c.1254 T>G p.I418M; c.1015 C>T p.R339X; c.1603 C>T p.R535X; c.1654 C>T p.L552F; c.1307 C>T p.S436L; c.279+3 A>G; c. 2150(delC) p.A717VfsX7; c.1733 T>C p.L578P; c.1109+5 G>A; c.221+31 A>G; c.367 C>T p.R123X; c.1857_1859delCAT; p.I619del] in the homozygous or the compound heterozygous state. Homozygosity or compound heterozygosity for two nonsense mutations was never found. In four cases the sequencing analysis has failed to find two mutations. To discuss the putative functional consequences of missense mutations, computational analysis and sequence alignment were performed. Our data underscore the high allelic heterogeneity of CDA II, as the most of SEC23B variations are inherited as private mutations. In this mutation update, we also provided a tool to improve and facilitate the molecular diagnosis of CDA II by defining the frequency of mutations in each exon.
Abnormal lung function associated with asbestos disease of the pleura, the lung, and both: a comparative analysis.
Authors: K. H. Kilburn, R. H. Warshaw
Journal: Thorax (1991)

The impairment of lung function associated with different types of asbestos related disease was examined in 1298 men. The 310 men with circumscribed pleural lesions (plaques) or diffuse pleural thickening without asbestosis were compared with 596 men with asbestosis only and with 322 men with pleural abnormalities and asbestosis, as classified from chest radiographs by ILO pneumoconiosis criteria. Spirometric indices and total lung capacity (TLC; determined by planimetry) were measured and expressed as percentages of predicted values. Non-smoking men with pleural disease only had reduced values of mid and terminal expiratory flows (80.6 and 69.9% predicted) and a reduced FEV1 (89% predicted) with a forced vital capacity (FVC) of 94% predicted. TLC was 104% predicted. Thus they had airways obstruction with-out restriction. Non-smoking men with pulmonary asbestosis (ILO profusion of opacities mostly 1/0 and 1/1) had pulmonary function similar to that of men with pleural disease. FEV1 and FVC and flow rates at other lung volumes were lower in smokers with asbestosis (after adjustment for duration of smoking) than in the non-smokers with asbestosis. Airflow limitation was worse in the men with both pleural abnormalities and pulmonary asbestosis with lower values for mid expiratory flow, FEV1 and FVC (but not TLC) than those with either abnormality alone, in both non-smokers and current smokers. Men with diffuse pleural thickening that included the costophrenic angles had more airways obstruction and air trapping and lower FVC values than those with circumscribed pleural disease.
FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets
Authors: Naonobu Nishino, Yoshikazu Tamori, Sanshiro Tateya, Takayuki Kawaguchi, Tetsuro Shibakusa, Wataru Mizunoya, Kazuo Inoue, Riko Kitazawa, Sohei Kitazawa, Yasushi Matsuki, Ryuji Hiramatsu, Satoru Masubuchi, Asako Omachi, Kazuhiro Kimura, Masayuki Saito, Taku Amo, Shigeo Ohta, Tomohiro Yamaguchi, Takashi Osumi, Jinglei Cheng, Toyoshi Fujimoto, Harumi Nakao, Kazuki Nakao, Atsu Aiba, Hitoshi Okamura, Tohru Fushiki, Masato Kasuga
Journal: Journal of Clinical Investigation (2008)

White adipocytes are unique in that they contain large unilocular lipid droplets that occupy most of the cytoplasm. To identify genes involved in the maintenance of mature adipocytes, we expressed dominant-negative PPARgamma in 3T3-L1 cells and performed a microarray screen. The fat-specific protein of 27 kDa (FSP27) was strongly downregulated in this context. FSP27 expression correlated with induction of differentiation in cultured preadipocytes, and the protein localized to lipid droplets in murine white adipocytes in vivo. Ablation of FSP27 in mice resulted in the formation of multilocular lipid droplets in these cells. Furthermore, FSP27-deficient mice were protected from diet-induced obesity and insulin resistance and displayed an increased metabolic rate due to increased mitochondrial biogenesis in white adipose tissue (WAT). Depletion of FSP27 by siRNA in murine cultured white adipocytes resulted in the formation of numerous small lipid droplets, increased lipolysis, and decreased triacylglycerol storage, while expression of FSP27 in COS cells promoted the formation of large lipid droplets. Our results suggest that FSP27 contributes to efficient energy storage in WAT by promoting the formation of unilocular lipid droplets, thereby restricting lipolysis. In addition, we found that the nature of lipid accumulation in WAT appears to be associated with maintenance of energy balance and insulin sensitivity.
Is considering true possibilities a truly explanatory principle for imaginative thought?
Authors: Thomas B. Ward
Journal: Behavioral and Brain Sciences (2007)

Abstract Byrne (2005) demonstrates that reasoning and imagination are logical and governed by the same processing principles. In extending those principles to other forms of imaginative functioning, however, problems arise. The meaning of “true possibility” is stretched, and the causal role of the principles is not well established. Nevertheless, consideration of the extent to which ordinary cognitive processes govern creative functioning is valuable.
Myelodysplasia: Decision for Death or Disability
Authors: David B. Shurtleff, Patricia W. Hayden, John D. Loeser, Richard A. Kronmal
Journal: New England Journal of Medicine (1974)

Abstract Treatment of myelodysplastic patients must avoid neglecting a potentially functional child on the one hand and the perpetuation of rejected, brain-damaged cripples on the other. Immediate, complete assessment for brain mass and function and other system anomalies were documented before treatment of 371 patients, with fully informed consent. Of these, 283 had maximum treatment because their brain mass was estimated to be 60 per cent of normal, or greater, and there were no noteworthy complications. The others were treated symptomatically. Seventy-five per cent of patients of normal intellect but paralyzed at high and 90 to 95 per cent of those paralyzed at low levels survived with maximum treatment. Of the patients treated only symptomatically because of criteria excluding maximum treatment, 10 per cent survived to the age of 2 1/2 years. There was a slightly better survival in a group treated symptomatically (42 per cent survival to teen age) before establishment of selection criteria. Children should be treated when parents knowingly accept the ultimate outcome or when doubt of potential exists. Continued reassessment is necessary to alter individual treatment policy. (N Engl J Med 291:1005–1011, 1974)
On the Right Management of Women: At First Menstruation, and during the Persistence of That Function
Authors: E. J. Tilt
Journal: BMJ (1851)

utility in rheumatic diseases, and m-any of these cases of local paralysis are probably due to an inflammation, (either gouty, rheumatic, or syphilitic,) of the fibrous sheath of the nierves.We see the great advantage of this remedy in promoting absorption of solid effused matter in cases of iritis, and why should it not have the same power upon organs and similar tissues that alc out of sight?I am convinced that it has frequently cured cases under my care when other modes proved to be inefficient, and of this I have brought forward one or two examples this evening, but, as I before stated, these cases were not intended to illustrate any special mode of treatment, or any peculiar success in treatment, but I have brought them before the Societv for the Feme reison as that for wbhich I collected them, viz., to illustrate some of these interesting points in the physiology of the nerves.
Determinants of nitric oxide in exhaled gas in the isolated rabbit lung.
Authors: R E Carlin, L Ferrario, J T Boyd, E M Camporesi, D J McGraw, T S Hakim
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Nitric oxide concentrations in the exhaled gas (NOe) increases during various inflammatory conditions in humans and animals. Little is known about the sources and factors that influence NOe. NOe at end expiration was measured by chemiluminescence in an isolated, blood-perfused rabbit lung. The average end-expiratory concentration over 10 breaths was used. The effect of positive end-expiratory pressure (PEEP), flow rate, pH, hypoxia, venous pressure, and flow pulsatility on NOe were determined. At constant blood flow, increasing PEEP from 1 to 5 cm H2O elicited a reproducible increase in NOe from 49 +/- 7 to 53 +/- 8 parts per billion (ppb) (p < 0.05). When blood pH was increased from 7.40 to 7.74 by breathing low CO2 gas, NOe rose from 45 +/- 7 to 55 +/- 7 ppb (p < 0.001). Hypoxia caused a dose-dependent decrease in NOe from 37 +/- 3 during baseline to 23 +/- 2 during ventilation with 0% O2 (p < 0.01). Venous pressure elevation from 0 to 5 and 10 mm Hg decreased NOe from 32 +/- 5, to 26 +/- 5 and 24 +/- 5 ppb, respectively (p < 0.05). Switching from steady to pulsatile flow (same man flow) resulted in a small, albeit significant reduction in NOe; 30 +/- 4 to 28 +/- 4 ppb (p < 0.05). Changes in flow rate between 200 and 20 ml/min were associated with small changes in NOe; however, when flow was stopped, NOe rose substantially to 56 +/- 6 ppb (p < 0.05). The changes in NOe were rapid (1 to 2 min) and reversible. The results suggest that NOe is influenced by ventilatory and hemodynamic variables, pH, and hypoxia. We suggest that caution must be taken when interpreting changes in exhaled NO in humans or experimental animals. Changes in total and regional blood flow, capillary blood volume, ventilation, hypoxia, and pH should not be overlooked.