tbuckley/cabot-search huggingface dataset:
Antibodies in human sera to oncorna virus-like proteins from normal or leukemia marrow cell cultures.
Authors: S Louie, J E Curtis, J E Till, E A McCulloch
Journal: The Journal of Experimental Medicine (1976)

Some human marrows in culture release particles with oncornavirus-like properties. This study was designed to examine the immunological properties of similar particles in human marrow culture supernates. Leukemic and nonleukemic marrows were cultured for 5-7 days in the presence of [14C]uridine and [3H]leucine or [3H]glucosamine. Labeled supernatant components banding in sucrose gradient densities of 1.20-1.24 g/ml were used as antigen in a double antibody immunoprecipitation assay. The assay was validated by end point titrations and competition with unlabeled antigen; purified myeloma proteins were used as negative controls. Cross-reactivity with mammalian oncornaviruses, as judged by competitive inhibition of precipitation by these viruses, was slight and at the border of the sensitivity of the method. Precipitated antigens analyzed by SDS polyacrylamide gel electrophoresis contained three distinct polypeptides of about 70,000, 45,000 and 30,000 mol wt; these comigrated with the gp 70, pg 45, and p 30 of a murine leukemia virus. Similar polypeptides were obtained from both leukemic and nonleukemic marrow culture supernates. As determined by the radioimmunoprecipitation assay, 32 of 45 leukemic sera (71%), 36 of 45 normal sera (80%), 15 of 19 sera from family contacts of leukemic patients (79%), 14 of 21 cord blood specimens (67%), and 21 of 23 sera (91%) from patients with systemic lupus erythematosus had detectable antibody activity.
Expression of the c-kit receptor in hypomelanosis: a comparative study between piebaldism, naevus depigmentosus and vitiligo
Authors: E. DIPPEL, N. HAAS, J. GRABBE, D. SCHADENDORF, K. HAMANN, B.M. CZARNETZKI
Journal: British Journal of Dermatology (2006)

In order to investigate possible alterations in c‐kit protein expression on epidermal melanocytes in different hypopigmentary disorders, we have examined skin specimens from one patient with piebaldism, one patient with naevus depigmentosus, and five patients with vitiligo. Cryosections were examined by immunohistochemistry using monoclonal antibodies against the c‐kit protein (YB5.B8) and melanosomes (TA99). In piebaldism, hypomelanotic epidermis contained only a few TA99‐positive epidermal melanocytes and no detectable c‐kit protein, whereas in naevus depigmentosus the expression of c‐kit protein was strong, and TA99 immunoreactivity was faint. In vitiligo lesions, no epidermal immunoreactivity for melanosomes or c‐kit protein was found. Normally pigmented skin of all patients showed immunoreactivity of epidermal melanocytes for both c‐kit protein and melanosomes. Different hypomelanotic lesions can thus be differentiated by absent melanocyte c‐kit protein and low or no expression of melanosomal marker in piebaldism, normal c‐kit but low melanosome expression in naevus depigmentosus, and the absence of all melanocyte markers in vitiligo.
Postnatal Estradiol Up-regulates Lung Nitric Oxide Synthases and Improves Lung Function in Bronchopulmonary Dysplasia
Authors: Donald C. McCurnin, Richard A. Pierce, Brigham C. Willis, Ling Yi Chang, Bradley A. Yoder, Ivan S. Yuhanna, Philip L. Ballard, Ronald I. Clyman, Nahid Waleh, William Maniscalco, James D. Crapo, Peter H. Grubb, Philip W. Shaul
Journal: American Journal of Respiratory and Critical Care Medicine (2009)

Rationale: Nitric oxide (NO) plays an important role in lung development and perinatal lung function, and pulmonary NO synthases (NOS) are decreased in bronchopulmonary dysplasia (BPD) following preterm birth. Fetal estradiol levels increase during late gestation and estradiol up-regulates NOS, suggesting that after preterm birth estradiol deprivation causes attenuated lung NOS resulting in impaired pulmonary function.Objective: To test the effects of postnatal estradiol administration in a primate model of BPD over 14 days after delivery at 125 days of gestation (term = 185 d).Methods: Cardiopulmonary function was assessed by echocardiography and whole body plethysmography. Lung morphometric and histopathologic analyses were performed, and NOS enzymatic activity and abundance were measured.Measurements and Main Results: Estradiol caused an increase in blood pressure and ductus arteriosus closure. Expiratory resistance and lung compliance were also improved, and this occurred before spontaneous ductal closure. Furthermore, both oxygenation and ventilation indices were improved with estradiol, and the changes in lung function and ventilatory support requirements persisted throughout the study period. Whereas estradiol had negligible effect on indicators of lung inflammation and on lung structure assessed after the initial 14 days of ventilatory support, it caused an increase in lung neuronal and endothelial NOS enzymatic activity.Conclusions: In a primate model of BPD, postnatal estradiol treatment had favorable cardiovascular impact, enhanced pulmonary function, and lowered requirements for ventilatory support in association with an up-regulation of lung NOS. Estradiol may be an efficacious postnatal therapy to improve lung function and outcome in preterm infants.
On the Payment of Certificates for Life Assurance
Authors: T. Jeffreys
Journal: BMJ (1842)

INSURANCE CERTIFICATES.-SICKCLUBS.77 combined, in order to arrive at a just result in such an inquiry.On a division the numbers were,- For Mr. Wakley's amendment 22 Against it . . . . . . . . . .19 Majority .. ... -3 Lord G. SOMERSET hereupon said, he hardly knew what course to adopt now, as he knew not whether the intention of the house was to favour the medical or the legal authority.Mr. WAKLEY said, he had no doubt whatever as to the perfect practicability of carrying ouit beneficially the principle which the house, he vas glad to sav, had affirmed.Perhaps it would
Response of tertiary centres to pressure changes. Is there a mechano-electrical association?
Authors: D. A Sideris, S. T Toumanidis, E. B Kostis, K. Stagiannis, G. Spyropoulos, S. D Moulopoulos
Journal: Cardiovascular Research (1990)

To investigate the mechanism of pressure related ventricular arrhythmias by examining them during atrioventricular (AV) block.Complete AV block, where all ventricular beats are ectopic, was induced by AV node ablation and/or by toxic digitalisation, and rhythm changes were studied while arterial blood pressure was repeatedly raised and lowered.15 anaesthetised mongrel dogs, weight 15-28 kg, were used. AV block was induced in eight by chemical or mechanical ablation of the AV node. In five of these and in seven other dogs, 5.0-7.5 mg digoxin was also given.Following AV block due to ablation, a heart rate increase (or no change) was found in 87.5% of 56 arterial pressure increases produced by elevation of an open arterial blood reservoir or by metaraminol infusion, but in only 21.8% of 55 pressure decreases caused by arterial bleeding (p much less than 0.001). Following AV block due to digitalisation, the equivalent figures were 96% of 50 pressure increases and 27.3% of 55 pressure decreases (p much less than 0.001). While arterial pressure was increased there was moderate acceleration of the escape rhythm, then appearance of premature ventricular beats, then non-sustained and finally sustained ventricular tachycardia. The reverse occurred, with some hysteresis, on decreasing the arterial pressure. In five of the digitalised animals, arterial pressure reduction to nearly zero caused reproducible sudden arrest, with resumption of the ordinary escape rhythm on increasing the pressure again.The findings suggest the possibility of two kinds of ectopic rhythm in AV block: the "normal" escape rhythm which is only moderately affected by arterial pressure changes; and an "abnormal" faster pressure dependent rhythm which is generated by high arterial pressure and abolished by pressure near zero, as if there were a mechano-electrical association. This abnormal rhythm may prevail completely in digitalis toxicity so that if cardiac arrest occurs, no automaticity can be expected to appear unless arterial pressure is raised.
EVALUATION OF METAIODOBENZYLGUANIDINE (MIBG) UPTAKE BY THE NOREPINEPHRINE AND DOPAMINE TRANSPORTERS
Authors: J V Glowniak, J Kilty, S Amara, F E Turner
Journal: Clinical Nuclear Medicine (1992)

Veterans Affairs Medical Center and the Vollum Institute, Oregon Health Sciences University, Portland, OR and Program i n Neurosciences, Yale University, School of Medicine, New Haven CT.
The General Medical Council and the future of revalidation: GMC prepares to deliver notable improvements
Authors: Amanda Watson
Journal: BMJ (2005)

The General Medical Council and the future of revalidation GMC member respondsEditor-Esmail and Kmietowicz give an inaccurate account of the General Medical Council's policy development on revalidation, ignoring an iterative process with interested parties since 1998 in an attempt to introduce the most fundamental change to medical regulation since its foundation in 1858. 1 2 The GMC clearly has had regard to the legitimate interests of three principal groups-government and the NHS, patients and the public, and the various tribes that make up the UK medical profession.Despite suggestions to the contrary, an initial exploratory meeting on revalidation convened by Sir Donald Irvine in June 1998 was held in the context of a high profile professional conduct case, but well before the Bristol inquiry report and absolutely nothing to do with Rodney Ledward or, indeed, Harold Shipman.It was recognised then that some doctors were not keeping fully up to date nor were they indulging in reflective practice.Irvine correctly proposed that there was a need to make registration with the GMC more meaningful to the public than a mere recognition that doctors had reached a certain standard of professional knowledge in their early 20s.Both articles promote the idea that the doctors' regulator should be filling the vacuum within the NHS created by its failing to fulfil its public responsibility to monitor doctors' clinical standards.Clinical governance is now, slowly, being developed and eventually will extend from systems and teams to individuals-but is it reasonable, as both authors postulate, that such monitoring should become the financial and moral responsibility of the GMC sitting in London and Manchester rather than local managers at the coalface?Although revalidation is a continuing process, it becomes summative only every five years.The NHS and its local systems must not be allowed to abrogate their responsibility for the safety of patients on a day to day basis.Nor should they demand that the GMC and its prime function of assuring fitness to practise and the meaning of the medical register be inappropriately promoted as the first line of defence for the maintenance of clinical quality and safety.
Skin Conditions of Infancy and Childhood--II
Authors: M. Beare
Journal: BMJ (1965)

In the first part of this article printed in last weeks BM.7. (p.171) I discussed the skin conditions that are common in children who are less than a year old.This week's article is concerned with the skin conditions found in children over this age.The Eceas Seborrhoeic eczema becomes increasingly uncommon after the age of 1 year, but aropic eczema becomes a little more common.Up to the age of approximnately 3 years atopic eczema tends to affect the dorsal surfaces of the hands and wrists, the front of the ankles, and the dorsal surfaces of the feet rather than the PIG.1.-Typical seborrhoeic eczema of the napkin area which has been aggravated-but not caused by-ammoniacal urine.flexural aspects of the limbs.After the age of 3, however, the elbow and knee flexures become involved and in older children the condition tends to be predomnantly flxural (" flexural I wish to thank my general-practitioner colleagues, Dr.
Ignorance and certainty
Authors: J. Smith
Journal: BMJ (2009)

Most weeks the BMJ , like most other journals, adds small bits of knowledge to what we already know. But we also accumulate more things that we don’t know—and this week’s issue has some important bits of ignorance.

We still don’t, for example, know how many cases of variant Creutzfeldt-Jakob disease (caused by exposure to bovine spongiform encephalopathy in cattle) there might be. The study by Jonathan Clewley and colleagues tested 63 007 tonsils and detected no disease related prion protein, but the confidence interval was 0 to 289 cases per million, lower than but still consistent with an earlier prevalence …
GLAUCOMA FOLLOWING TRAUMATISM, UNASSOCIATED WITH DISLOCATION OF THE LENS.
Authors: G. E. DE SCHWEINITZ
Journal: JAMA (1898)

In the general rejoicing of theAmerican Medical Associationon its fiftieth anniversary the Ophthalmic Section heartily joins, and all the more heartily because by reason of its own clean record, steady development and fair achievements, it has become a model Section of this notable gathering of American physicians and surgeons. To have been chosen to preside over its deliberations is a satisfaction for which I return my sincere thanks; to become the successor of the men who have labored so hard and so productively for the advancement of this Section and for the credit of ophthalmology is an honor I highly appreciate; to welcome you, my<i>confrères</i>, perhaps I may be permitted to say, my friends, on this occasion and on all other occasions when you shall gladden us with your presence, is a pleasure I greatly enjoy. The Chairman's address was at one time, by the organic law
[255] RELATION BETWEEN T29C SINGLE NUCLEOTIDE POLYMORPHISM OF ESTROGEN RECEPTOR ALPHA (ESR1) AND HBV-RELATED HEPATOCELLULAR CARCINOMA IN A CHINESE POPULATION
Authors: G.H. Deng, R. Zhang, G.Q. Zhou, L. Chen, F.C. He, Y.M. Wang
Journal: Journal of Hepatology (2007)
Abstract 3107: Semaphorin 4D – plexin B1 signaling in pancreatic ductal adenocarcinoma reflects tumor aggressiveness
Authors: Kato Shingo, Kensuke Kubota, Takeshi Shimamura, Noritoshi Kobayashi, Seitaro Watanabe, Yoshiyasu Shinohara, Hitoshi Ishiguro, Noboru Nakaigawa, Yoshinobu Kubota, Shin Maeda, Atsushi Nakajima
Journal: Cancer Research (2011)

Abstract Purpose: Semaphorins are a large family of proteins that provide axonal guidance in neuronal tissues and regulate cell motility in many types of cells. In recent studies, Semaphorin 4D (Sema4D) has been demonstrated to enhance the motility and invasiveness of cancer cells through its receptor, plexin B1, in vitro and also to increase the metastatic potential of breast cancer in vivo. However, the expression patterns and functions of Sema4D in pancreatic cancer remain unknown. Experimental Design: We examined the expressions of Sema4D and plexin B1 in surgically resected specimens of pancreatic ductal adenocarcinoma by immunohistochemistry, and also the effect of Sema4D stimulation on the invasiveness of pancreatic cancer cells. Results: Immunohistochemical staining revealed that Sema4D was expressed on the T cells and B cells in the cancer stroma. Plexin B1 was expressed in the cancer cells, whereas its expression was only faintly detected in the normal pancreatic ductal cells. Tumors with higher expression levels of Sema4D showed a significantly higher tendency towards lymph node metastasis (p = 0.0068), distant metastasis (p = 0.036), extrapancreatic nerve plexus invasion (p = 0.0073), and a poor prognosis (p = 0.024). Increased expression of both Sema4D and plexin B1 was associated with an additive worsening of the prognosis, independent of the tumor-node-metastasis classification and the World Health Organization tumor grade (p = 0.045). Stimulation with Sema4D caused a significant increase in the invasiveness of pancreatic cancer cells, and the knockdown of plexin B1 by siRNA could block the enhanced invasive activity by Sema4D. Conclusion: Sema4D could play a role in the interactions between the tumor cells and the tumor microenvironment in pancreatic cancer. In the context of numerous attempts currently ongoing to target the tumor stroma, our findings provide insight into new molecular targets for the development of treatments for pancreatic cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3107. doi:10.1158/1538-7445.AM2011-3107
HYPOTENSION IN ACUTE DECOMPENSATED HEART FAILURE: FINDINGS FROM ASCEND-HF
Authors: Priyesh Ashok Patel, Gretchen Heizer, Christopher O'Connor, Kenneth Dickstein, Justin Ezekowitz, Victor Hasselblad, Barry Massie, Roger Mills, John McMurray, Randall Starling, Wai Hong Tang, Robert Califf, Adrian Hernandez
Journal: Journal of the American College of Cardiology (2013)
Spontaneously Disappearing Murmur of Patent Ductus Arteriosus
Authors: T. R. KEITH, J. SAGARMINAGA
Journal: Circulation (1961)

A 10-year-old girl with patent ductus arteriosus had most unusual auscultatory changes, but the typical roentgenologic and electrocardiographic findings. There was an intermittent, spontaneous disappearance and reappearance of the entire machinery murmur. At surgery, a valve, or veil-like structure, was found inside the ductus at its entrance into the pulmonary artery. This valve apparently accounted for the "spontaneous" intermittent disappearance of the murmur, which was first discovered when the child was 10 years old.
The Complementary Role of Hepatobiliary Scintigraphy and Abdominal Sonography in a Patient With a Hepatic Cyst and Suspected Acute Cholecystitis
Authors: IAN J. DUNN, EINAT EVEN-SAPIR, DAVID C. BARNES, SIÂN ILES
Journal: Clinical Nuclear Medicine (1993)

A 51-year-old woman was admitted with suspected acute cholecystitis. A large hepatic cyst was found incidentally by abdominal sonography, which displaced an “abnormal” gallbladder. Hepatobiliary scintigraphy visualized the gallbladder and excluded acute cholecystitis, but required the anatomic information from sonography to verify the abnormal location of the gallbladder. Additionally, scintigraphy showed the cyst not to communicate with the biliary tract. Pathologic findings revealed mild chronic cholecystitis and a simple mesothelial hepatic cyst. This case illustrates the complementary role of hepatobiliary scintigraphy and abdominal sonography in patients with distorted hepatobiliary anatomy and suspected acute cholecystitis.
Psychological Stress in Wives of Patients with Myocardial Infarction
Authors: M. Skelton, J. Dominian
Journal: BMJ (1973)

In a study of the psychological consequences of myocardial infarction on 65 wives of husbands admitted to a coronary care unit feelings of loss, depression, and guilt were common at the time of infarction. Many wives (38%) found the period of convalescence after discharge very stressful, attributing this to fears of a recurrent infarct and marital tension owing to their husbands' increased irritability and dependency. These anxieties and tensions gradually diminished and at one year after the initial illness only eight wives whose husbands had made a good physical recovery still showed considerable psychological disturbance. It is suggested that unnecessary emotional distress, particularly in the initial period after discharge from hospital, can be alleviated by increased help and support from the hospital and family doctor.
Utilization of blood cultures in Danish hospitals: a population-based descriptive analysis
Authors: S. Gubbels, J. Nielsen, M. Voldstedlund, B. Kristensen, H.C. Schønheyder, C.M.J.E. Vandenbroucke-Grauls, M. Arpi, M.K. Björnsdóttir, J. Dahl Knudsen, R.B. Dessau, T. Gorm Jensen, P. Kjældgaard, L. Lemming, J.K. Møller, D. Schrøder Hansen, K. Mølbak
Journal: Clinical Microbiology and Infection (2014)
Acute HIV infection at travel clinics – Authors' reply
Authors: Alberto Matteelli, Patricia Schlagenhauf, Anna CC Carvalho, Leisa Weld, Xiaohong M Davis, Annelies Wilder-Smith, Elizabeth D Barnett, Philippe Parola, Prativa Pandey, Pauline Han, Francesco Castelli
Journal: The Lancet Infectious Diseases (2013)
Peripheral paediatric clinics: survey and medical audit.
Authors: S D Weller
Journal: BMJ (1975)

The work of the paediatric clinics in nine general-practitioner hospitals in country towns in the Bath Health District during 1972 was analysed with respect to the pattern of referrals and methods of management. It is concluded that no child suffered harm from being seen in a clinic without full laboratory and x-ray facilities. Nearly 98% of the consultations were deemed, even with a long period of hindsight, to have been completely satisfactory. The tremendous benefit to the patients and their families of being seen in a hospital near their home is not bought at the cost of a second-rate medical service.
Antibiotics Before Endoscopy
Authors: ROBERT G. NORFLEET
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 March 1983Antibiotics Before EndoscopyROBERT G. NORFLEET, M.D.ROBERT G. NORFLEET, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-3-416_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The letter of Goldman and associates (1) supplies important information about bacteremia after flexible sigmoidoscopy. Their study is well done, but I believe their conclusion—that patients with cardiac lesions predisposing to endocarditis should be treated with prophylactic antibiotics before flexible sigmoidoscopy—is in error for several reasonsFirst, a huge number of patients would have to be "protected"; 6.3% of American women have mitral valve prolapse (2). When persons with other valvular and congenital heart disease are added, there will be a very large expense for and risk from the antibiotics administered.Second, the incidence of bacteremia reported...References1. GOLDMANMILLERFURMANBROCKRYANMCCALLUM GSDDRR. Sigmoidoscopy and bacteremia. [Letter]. Ann Intern Med. 1982;97:784-5. LinkGoogle Scholar2. PROCACCISAVRANSCHREITERBRYSON PSSA. Prevalence of clinical mitral-valve prolapse in 1169 young women. N. Engl J Med. 1976;294:1086-8. CrossrefMedlineGoogle Scholar3. HOFFMANKOBASAKAYE BWD. Bacteremia after rectal examination. Ann Intern Med. 1978;88:658-9. LinkGoogle Scholar4. WILSONVAN SCOYWASHINGTON WRJ. Incidence of bacteremia in adults without infection. J Clin Microbiol. 1975;2:94-5. CrossrefGoogle Scholar5. LE FROCKELLISKLAINERWEINSTEIN JCAL. Transient bacteremia associated with barium enema. Arch Intern Med. 1975;135:835-7. CrossrefMedlineGoogle Scholar6. NORFLEETMULHOLLANDMITCHELLPHILOWALTERS RDPJE. Does bacteremia follow colonoscopy? Gastroenterology. 1976;70:20-1. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Marshfield Medical Center Marshfield, WI 54449 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1983Volume 98, Issue 3Page: 416-416KeywordsAntibioticsBacteremiaCongenital heart diseaseEndocarditisEndoscopyFlexible sigmoidoscopyLesionsMitral valve prolapse Issue Published: 1 March 1983 PDF DownloadLoading ...