tbuckley/cabot-search huggingface dataset:
Miliary Tuberculosis and Respiratory Distress Syndrome
Authors: JOHN T. HSU
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 July 1978Miliary Tuberculosis and Respiratory Distress SyndromeJOHN T. HSU, M.D., JOSEPH P. PADULA, M.D., STEPHEN F. RYAN, M.D.JOHN T. HSU, M.D., JOSEPH P. PADULA, M.D., STEPHEN F. RYAN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-1-140_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the reported cases of miliary tuberculosis associated with adult respiratory distress syndrome, histologic findings have not been discussed (1). We report here an additional case with the emphasis on the histopathologic features. Its possible pathogenesis is discussed in relation to the experimental work of one of the authors.A 64-year-old nonsmoking, alcoholic, black woman with chemical diabetes was admitted with a 2-month history of malaise followed by 1 week of fever and cough that produced a small amount of white sputum. She was febrile, tachycardic, and tachypneic. Diffuse pulmonary rales and a 25-cm liver were noted....References1. HUSEBYHUDSON JL: Miliary tuberculosis and adult respiratory distress syndrome. Ann Intern Med 85:609-611, 1976 LinkGoogle Scholar2. BERGERSAMORTIN HT: Miliary tuberculosis: diagnostic methods with emphasis on the chest roentgenogram. Chest 58:586-589, 1970 CrossrefMedlineGoogle Scholar3. KATZENSTEINBLOORLIEBOW ACA: Diffuse alveolar damage—the role of oxygen, shock and related factors. Am J Pathol 85:210-228, 1976 Google Scholar4. NASHFOLEYLANCLINAIS GFP: Pulmonary interstitial edema and hyaline membrane in adult burn patients: electron microscopic observations. Hum Pathol 5:149-160, 1974 CrossrefMedlineGoogle Scholar5. RYAN S: Experimental fibrosing alveolitis. Am Rev Respir Dis 105:776-791, 1972 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Luke's Hospital Center New York, NY 10025 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTuberculosis in the Intensive Care UnitPulmonary Tuberculosis Presenting as Acute Respiratory Failure: Radiologic FindingsMiliary tuberculosis and the adult respiratory distress syndromeHuman Reproduction: Regulated Progress or Damned Interference?IMMUNE REACTIONS IN TUBERCULOSISCAUSES OF THE ADULT RESPIRATORY DISTRESS SYNDROME—CLINICAL RECOGNITION 1 July 1978Volume 89, Issue 1Page: 140-141KeywordsAcute respiratory distress syndromeAlcoholicsFeversLiverMiliary tuberculosisPathogenesisRespiratory distress syndromeSputum Issue Published: 1 July 1978 PDF downloadLoading ...
Minnesota State Board of Health and Vital Statistics.
Authors: Charles N. Hewitt
Journal: JAMA (1893)

<h3>Office of Secretary and Executive Officer, Red Wing, Minn., Nov. 6, 1893.</h3><h3>To the Editor:</h3> —I beg to report that a case of confluent smallpox has appeared in the person of a boy, Elmer Rogers, age 11, and unvaccinated, in the town of Featherstone, Goodhue County. He is a resident, and at the time of exposure was traveling from Virginia through Pennsylvania, Indiana, Ohio, Illinois to Minnesota, so that it is difficult to say where, in those States, he took the infection. I was called by the family Friday the 3d of November and found a well-marked case of confluent smallpox, the eruption having begun on Monday four days before. The attending doctor supposed the disease chickenpox. A careful list was made of all persons who had visited the family since the preceding Saturday. I visited, vaccinated and put under observation all who had been exposed since Sunday. There are
Does Exercise Without Weight Loss Improve Insulin Sensitivity?
Authors: Robert Ross
Journal: Diabetes Care (2003)

It has long been established that a single exercise session can increase insulin-stimulated glucose uptake in previously sedentary adults (1). A single bout of moderate intensity exercise can increase glucose uptake by at least 40% (2). The benefits of exercise diminish rather quickly, however, as the effects generally dissipate within 48 to 72 h of the last exercise session (3). This observation is reinforced by investigations demonstrating that cessation of exercise in trained persons is associated with a marked and rapid decrease in insulin sensitivity (4). A detailed review of the putative mechanisms by which exercise enhances insulin action is the subject of several excellent reviews (5,6).

Although a single bout of exercise improves glucose metabolism acutely, the impact of exercise training (e.g., the summation of acute bouts of exercise) on glucose metabolism is unclear. The issue is not whether exercise training is associated with improvement in glucose tolerance and insulin action. Recognition that exercise training enhances the ability of skeletal muscle to glucose uptake was reported over 30 years ago when Bjorntorp et al. (7) observed that insulin action is greater in physically active than sedentary individuals. Rather, the issue is whether the impact of exercise training on glucose metabolism is a direct effect or an indirect effect that depends on concomitant reduction in body fat …
Altered immunoglobulin metabolism in systemic lupus erythematosus and rheumatoid arthritis
Authors: Joshua Levy, Eugene V. Barnett, Norman S. MacDonald, James R. Klinenberg
Journal: Journal of Clinical Investigation (1970)

IgG and IgM metabolism was evaluated in 10 patients with systemic lupus erythematosus (SLE), 10 patients with rheumatoid arthritis (RA), and in seven normal volunteers. The biological half-lives of purified IgG and IgM, labeled with (131)I and (125)I, respectively, were determined by serial measurements of radioactivity in the blood and urine with a gamma well counter, and by serial counts of total body radioactivity in a total body counting chamber. The mean survival half-life for IgG in patients with SLE was 8.2 days as compared to an average of 18 days in normal controls. An average of 10.1% of total body IgG was catabolized daily compared to a mean of 3.9% in normal controls. Turnover of IgM in patients with SLE was, with very few exceptions, normal. In contrast, patients with rheumatoid arthritis revealed a milder abnormality of IgG metabolism, but markedly abnormal IgM catabolism with a mean half-life averaging 5.9 days as compared to 9.3 days in control subjects. An average of 14.2% of total body IgM was catabolized daily in patients with RA as compared to 8.1% in normal controls. Our data suggest that there are basic differences between patients with RA and SLE in the synthesis and catabolism of IgG and IgM not readily apparent from serum IgG and IgM concentration. Abnormal IgG and IgM metabolism may be related to underlying immunological mechanisms in these diseases. Immunoglobulin turnover studies appear to be an additional means for the characterization of rheumatic diseases.
34 LIVER TRANSPLANTATION AFTER CARDIAC DEATH DONATION: SINGLE-CENTRE LONG-TERM RESULTS
Authors: W. Jassem, R. Valente, D. Chasiotis, S. Khorsandi, T. Cherian, H. Vilca Melendez, A. Prachalias, P. Srinivasan, M. Heneghan, M. Rela, N. Heaton
Journal: Journal of Hepatology (2011)
Subpopulations of rat vascular smooth muscle cells as discriminated by calcium release mechanisms from internal stores.
Authors: W S Shin, T Toyo-oka, M Masuo, Y Okai, H Fujita, T Sugimoto
Journal: Circulation Research (1991)

Transsarcolemmal influx and release from the sarcoplasmic reticulum (SR) through specific Ca2+ channels are the two main pathways to elevate cytosolic Ca2+ (Ca2+i) in vascular smooth muscle cells (VSMCs). To elucidate intercellular distribution and function of the Ca2+ channel in SR in cultured VSMCs, we observed Ca2+i transients by digital two-dimensional imaging with a fluorescent Ca2+ indicator, fura-2, and found an alternative response to either caffeine or angiotensin II under the condition that selectively enabled Ca2+ release from SR. Caffeine (20 mM) increased the Ca2+i by 292 +/- 36% (mean +/- SEM) over the basal level in one third of the VSMC population (n = 19), while the remaining cells in the same observation field showed no or very weak response (110 +/- 4%). In contrast, after the treatment with caffeine plus ryanodine (30 microM), which inactivates the caffeine-sensitive channel, and with 1 mM Ca2+ chelator (EGTA) instead of Ca2+ in the incubation medium to block the CA2+ entry from outside, angiotensin II (10 nM) induced the Ca2+i elevation (287 +/- 26%) in previously caffeine-nonresponsive cells, although caffeine-responsive cells retained quiescence (112 +/- 2%). These responses did not differ when the order of the reagent application was reversed. These heterogeneities of VSMCs in the Ca2+i response to vasoactive substances indicate that VSMCs are functionally divided into subgroups with different Ca2+ channel predominance on SR, necessitating reevaluation of the previous studies obtained from multiple VSMCs.
P2-159: Phase III randomized study of oral vinorelbine (oV) and gemcitabine (G) (oVG) versus docetaxel (D) and gemcitabine (DG) as first-line treatment of patients with advanced non-small cell lung cancer (NSCLC): A preliminary report
Authors: S Agelaki, N Androulakis, A Agelidou, M Agelidou, A Kotsakis, A Polyzos, N Kentepozidis, N Ziras, D Mavroudis, V Georgoulias
Journal: Journal of Thoracic Oncology (2007)
ABC of ophthalmology.
Authors: K D Foggitt
Journal: BMJ (1979)

hypnotised and trained in autohypnosis to avert an attack.This can be perfected so that it is effective in a fraction of the time for chemotherapy, without any side effects, without any need for "sleeping away" the illness, and without the incapacity.Hypnosis is more time consuming than writing a prescription, but far less so than most physicians realise; and it has the added merit of permanent remission in appreciable numbers of sufferers.
Influenza immunization in patients with chronic renal disease
Authors: D. W. Ortbals
Journal: JAMA (1978)

Patients receiving long-term hemodialysis (23) and patients with moderate to severe renal impairment and without hemodialysis (14) were immunized with inactivated influenza A/New Jersey/76 whole virus vaccine. Fourfold or greater increases in hemagglutinating-inhibiting antibody (HAI) titers occurred in 94% of controls, 93% of nondialyzed patients with chronic renal disease, and 87% of patients with continual hemodialysis. Postimmunization geometric mean titers in both groups of patients were equivalent to those of controls. The proportion of patients responding to vaccine was independent of levels of creatinine clearance, and the presence of preimmunization HAI titers also had no effect on frequency of seroconversion. Though some element of immunologic suppression is associated with chronic renal disease, it is not reflected in the humoral antibody response to influenza A/New Jersey/76 vaccine. (<i>JAMA</i>239:2562-2565, 1978)
Successful treatment of severe refractory aplastic anemia with 3‐β etiocholanolone and nandrolone decanoate
Authors: T. R. Seewald, Z. R. Zeigler, F. H. Gardner
Journal: American Journal of Hematology (1989)

Abstract A patient with aplastic anemia, who had been unresponsive to androgens, antithymocyte globulin, high‐dose methylprednisolone, and cyclosporine, responded to treatment with 3‐β‐etiocholanolone, nandrolone decanoate, and prednisolone acetate. Six months following intiation of therapy, she became red cell and platelet transfusion independent with neutrophils persistently over 1,000/μl. A sustained partial remission has persisted for over 2 years. This observation suggests that a combined hematostimulatory approach may be of benefit, even in patients with long‐standing refractory aplasia.
Cardiovascular Disease in Dialysis Patients
Authors: Edmund G. Lowrie, J. Michael Lazarus, C. L. Hampers, John P. Merrill
Journal: New England Journal of Medicine (1974)

During the past several years evidence has been accumulating that cardiovascular disease is the leading cause of death among patients undergoing chronic hemodialysis therapy. Between 40 and 60 per cent of all such deaths have been from cardiovascular causes, and by far the leading contributor has been heart disease. Experience with large numbers of patients in both Europe1 and the United States2 has been remarkably similar in this regard, and our European colleagues have recently updated their data,1 which condense reports from 584 centers including over 13,000 patients. Their recorded experience spans some 10 years and suggests that approximately 50 . . .
Infant colic: Re-evaluating the adaptive hypotheses
Authors: Dario Maestripieri, Kristina M. Durante
Journal: Behavioral and Brain Sciences (2004)

Colic may allow infants to obtain additional investment from their parents. The lack of clear fitness costs of colic and of differences in condition between colicky and non-colicky infants is inconsistent with the hypotheses that colic is an honest signal of need or vigor. These and other characteristics of colic, however, are consistent with the hypothesis that colic is a manipulative signal.
Two cases of phosphofructokinase deficiency associated with congenital hemolytic anemia found in Japan
Authors: Kenzaburo Tani, Hisaichi Fujii, Susumu Takegawa, Shiro Miwa, Wataru Koyama, Masaaki Kanayama, Akihiro Imanaka, Fumio Imanaka, Atsushi Kuramoto
Journal: American Journal of Hematology (1983)

Two kindreds of phosphofructokinase (PFK) deficiency associated with congenital nonspherocytic hemolytic anemia and mild myopathy were found in Japan. Both probands had jaundice, gallstones, and slight to moderate degree of exercise intolerance. They showed decreased level of red cell PFK activity and no increase of blood lactate in forearm ischemic exercise test. We studied these probands' red cell PFKs by partial purification and condensation. Muscle type isozyme of PFK in both cases was not demonstrable in starch gel electrophoresis and DEAE-Sephadex chromatography. The clinical symptoms are considered to be due to a defect of muscle type isozyme.
ENDOTHERMY IN GYNECOLOGY
Authors: HOWARD A. KELLY
Journal: JAMA (1927)

In this country we owe the introduction of high frequency currents in general surgery to William L. Clark of Philadelphia and it is my purpose in this paper to speak of these currents in their application to gynecology. Not to enter into technical details, there are three currents available which differ widely from the familiar fulguration methods which were in vogue for some twenty years with more or less success, but which have proved disappointing owing to the lack of penetrating power. These currents are: (1) the monopolar, which is more or less superficial and which desiccates the surface but gains in penetration as the amperage is increased; (2) a bipolar damped current which coagulates the tissues and seals vessels and lymphatics, while sterilizing the area treated and destroying all malignant cells; (3) George A. Wyeth's "acusector," a rapidly oscillating undamped current with relatively low voltage and amperage, which turns
Neurovascular crosstalk between interneurons and capillaries is required for vision
Authors: Yoshihiko Usui, Peter D. Westenskow, Toshihide Kurihara, Edith Aguilar, Susumu Sakimoto, Liliana P. Paris, Carli Wittgrove, Daniel Feitelberg, Mollie S.H. Friedlander, Stacey K. Moreno, Michael I. Dorrell, Martin Friedlander
Journal: Journal of Clinical Investigation (2015)

Functional interactions between neurons, vasculature, and glia within neurovascular units are critical for maintenance of the retina and other CNS tissues. For example, the architecture of the neurosensory retina is a highly organized structure with alternating layers of neurons and blood vessels that match the metabolic demand of neuronal activity with an appropriate supply of oxygen within perfused blood. Here, using murine genetic models and cell ablation strategies, we have demonstrated that a subset of retinal interneurons, the amacrine and horizontal cells, form neurovascular units with capillaries in 2 of the 3 retinal vascular plexuses. Moreover, we determined that these cells are required for generating and maintaining the intraretinal vasculature through precise regulation of hypoxia-inducible and proangiogenic factors, and that amacrine and horizontal cell dysfunction induces alterations to the intraretinal vasculature and substantial visual deficits. These findings demonstrate that specific retinal interneurons and the intraretinal vasculature are highly interdependent, and loss of either or both elicits profound effects on photoreceptor survival and function.
Radiofrequency endocardial catheter ablation of accessory atrioventricular pathway atrial insertion sites.
Authors: J F Swartz, C M Tracy, R D Fletcher
Journal: Circulation (1993)

BACKGROUND High rates of success using radiofrequency ablation energy have rapidly transformed catheter ablation from an investigational procedure to the nonpharmacological therapy of choice for symptomatic Wolff-Parkinson-White syndrome. Prior studies of radiofrequency accessory pathway ablation were based on a ventricular approach. Risks associated with prolonged arterial catheter manipulation, retrograde left ventricular catheterization, and production of ventricular lesions required for successful ventricular insertion ablation can be avoided using atrial insertion ablation procedures. The purpose of the present study was to define the safety and efficacy of accessory pathway ablation using radiofrequency energy delivered solely to accessory atrioventricular pathway atrial insertion sites. METHODS AND RESULTS One hundred fourteen patients with accessory pathway-mediated tachycardia underwent attempted radiofrequency current ablation at the accessory pathway atrial insertion site. All catheters were introduced transvenously. Left-sided accessory pathways were approached using transseptal left atrial catheterization techniques. Retrograde localization of the atrial insertion site during reentrant tachycardia was characterized by 40 +/- 15-msec local ventriculoatrial and 79 +/- 17-msec surface QRS to local atrial electrogram intervals. Presumed accessory pathway potentials were present in only 30% of ablation site electrograms. Successful ablation required 6.2 +/- 5.3 radiofrequency energy applications. Cumulative energy dose required for success was 2,341 +/- 2,233 J. There were no complications associated with transseptal catheterization. Energy delivery to accessory pathway atrial insertion sites was associated with non-life-threatening complications in two patients. Recurrent conduction requiring repeat ablation occurred in 10 of 115 (9%) successfully ablated accessory pathways, all within 1 month of the ablation procedure. After 21.2 +/- 4.6 months of follow-up, 108 of 114 (95%) patients are asymptomatic and without evidence of accessory pathway conduction. CONCLUSIONS The atrial insertion approach to accessory pathway ablation is safe and highly effective. This approach compares favorably with the retrograde ventricular insertion ablation technique. Atrial insertion ablation eliminates the need to produce ventricular lesions and avoids the risks of prolonged arterial catheter manipulation and retrograde left ventricular catheterization.
EARLY CONVULSIONS IN EPILEPTICS AND IN OTHERS
Authors: HUGH T. PATRICK
Journal: JAMA (1924)

For many years, opinion on the significance of early convulsions has been most contradictory. Hammond, 1 in 1881, in opposition to the opinion prevailing at that time, wrote,  [infantile convulsions] may pass into epilepsy; but if they do not I have never been able to find a single instance in my experience in which epilepsy ensuing in adult life has been preceded by the ordinary infantile convulsions. Walton & Carter, 2 ten years later, discount any relationship between early convulsions and epilepsy. They tried to determine the relative frequency of early convulsions in epileptics and in the normal population, and, from the difference, to deduce the prognosis. They reasoned in this way: The incidence of epilepsy in the general population is about 6 per thousand. The incidence of infantile spasms in normal children is 111 per thousand (one in nine). Since only one in fourteen epileptics has infantile spasms,
Disseminated cryptococcal infection in a patient with severe psoriasis treated with efalizumab, methotrexate and ciclosporin
Authors: A.J. Tuxen, M.K. Yong, A.C. Street, C. Dolianitis
Journal: British Journal of Dermatology (2007)

Journal Article Disseminated cryptococcal infection in a patient with severe psoriasis treated with efalizumab, methotrexate and ciclosporin Get access A.J. Tuxen, A.J. Tuxen Department of Dermatology Correspondence: Alana J. Tuxen. E‐mail: alanatuxen@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar M.K. Yong, M.K. Yong Victorian Infectious Diseases Service, The Royal Melbourne Hospital, Grattan Street, Parkville, Vic. 3050, Australia Search for other works by this author on: Oxford Academic Google Scholar A.C. Street, A.C. Street Victorian Infectious Diseases Service, The Royal Melbourne Hospital, Grattan Street, Parkville, Vic. 3050, Australia Search for other works by this author on: Oxford Academic Google Scholar C. Dolianitis C. Dolianitis Department of Dermatology Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 157, Issue 5, 1 November 2007, Pages 1067–1068, https://doi.org/10.1111/j.1365-2133.2007.08171.x Published: 01 November 2007