tbuckley/cabot-search huggingface dataset:
Changes in the T-wave of the electrocardiograph in urticaria
Authors: Y. SHOENFELD, S. SCLAROVSKY
Journal: British Journal of Dermatology (1974)

Journal Article Changes in the T‐wave of the electrocardiograph in urticaria Get access Y. SHOENFELD, Y. SHOENFELD Beilinson Hospital, Petah Tikva, Israel Search for other works by this author on: Oxford Academic Google Scholar S. SCLAROVSKY S. SCLAROVSKY Beilinson Hospital, Petah Tikva, Israel Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 90, Issue 3, 1 March 1974, Pages 283–288, https://doi.org/10.1111/j.1365-2133.1974.tb06403.x Published: 01 March 1974 Article history Accepted: 15 June 1973 Published: 01 March 1974
Principles of Hematology
Authors: L. W. Diggs
Journal: JAMA (1970)

The author presents his material in the pleasing style of an effective teacher and gives the reader a new look at blood diseases from an individual and unorthodox point of view. The major emphasis is on the chemical changes associated with blood diseases. A fitting title of the book would be "Chemical Principles of Hematology." Twenty chapters are devoted to topics which include the morphology, formulation, and function of blood cells; pigment; iron and energy metabolism; megaloblastic and hemolytic anemias; hemoglobinopathies; systemic and malignant diseases; immunohematology; and blood coagulation. In addition there are chapters on the principles of fundamental laboratory measurements and the life span of erythrocytes. The morphology of normal and abnormal blood cells and the anatomical changes are dealt with in a superficial way. The line drawings of the various blood cells are diagrammatic, more suited for students in grammar school than for graduate students. The sections dealing
The Bronchodilator Effects of Aerosolized Terbutaline
Authors: Bruce F. Bachus
Journal: JAMA (1977)

The bronchodilator effects of aerosols of a high-dose of terbutaline sulfate (1.5 mg), a low-dose of terbutaline sulfate (0.75 mg), isoproterenol (0.3 mg), and placebo were compared using forced expiratory spirometry, flow-volume curves, and body plethysmography in a double-blind, six-hour, controlled study in 25 patients with reversible airflow obstruction. After isoproterenol therapy, the values peaked at 15 minutes, and none were significantly different (P less than .05) from placebo after the 30-minute observation point. The values for high-dose terbutaline peaked at one hour at a level that exceeded responses to isoproterenol. All values except the forced vital capacity at five and six hours and functional residual capacity at six hours were significantly greater than placebo (P less than .05) at all observation points. The low-dose terbutaline values peaked earlier and at a lower value than the high-dose terbutaline values, and several indexes were significantly greater (P less than .05) than after isoproterenol therapy beyond the two-hour point.
Induction of lung-specific DNA damage by metabolically methylated arsenics via the production of free radicals.
Authors: K Yamanaka, S Okada
Journal: Environmental Health Perspectives (1994)

To clarify the genotoxicity of inorganic arsenics, we focused on the genotoxic effect of metabolically methylated arsenics in mammals. Oral administration to mice of dimethylarsinic acid (DMAA), a major metabolite of inorganic arsenics, induced lung-specific DNA damage, i.e., DNA single-strand breaks and the clumping of heterochromatin. The lung-specific strand breaks were not caused by DMAA itself, but by dimethylarsine, a further metabolite of DMAA. An in vitro experiment indicated that DNA single-strand breaks by dimethylarsine were suppressed by the presence of superoxide dismutase and catalase, suggesting that the strand breaks were induced via the production of free-radical species including active oxygens. Dimethylarsenic peroxyl radical [(CH3)2AsOO.] and superoxide anion radical produced from the reaction between molecular oxygen and dimethylarsine were detected by electron-spin resonance analysis using a spin-trapping agent and the cytochrome-c method, respectively. Of these two radicals, the dimethylarsenic peroxyl radical rather than the superoxide anion radical is assumed to play the dominant role in causing the DNA damage, at least for DNA single-strand breaks.
Role of myocardial contrast echocardiography during nonsurgical septal reduction therapy for hypertrophic obstructive cardiomyopathy
Authors: Sherif F Nagueh, Nasser M Lakkis, Zuo-Xiang He, Katherine J Middleton, Donna Killip, William A Zoghbi, Miguel A Quiñones, Robert Roberts, Mario S Verani, Neal S Kleiman, William H Spencer
Journal: Journal of the American College of Cardiology (1998)
ABC of computing. Statistics and epidemiology.
Authors: A J Asbury
Journal: BMJ (1983)

Most investigational work requires some form of statistical manipulation, and the doctor contemplating a research project is often daunted by the arithmetic needed.The computer's ability to do repeated tasks, to store and retrieve information reliably, and to do all this fast, objectively, and efficiently makes it an ideal tool for statistical work.Initial planning: assessing the amount of data Consider a doctor starting a research project.He knows the medical problem but has little knowledge of statistics.The first step is to consult simple texts on statistics, or some of the papers that have appeared in the >30 records
U turn on cancer networks leaves question mark over arrangements for other diseases
Authors: H. Mooney
Journal: BMJ (2011)

The government’s radical plan to axe England’s NHS cancer networks has been scrapped after the health secretary, Andrew Lansley, was pressured into a U turn, raising questions about whether other specialist networks could also be spared.

Mr Lansley had been set to hand over control of the 28 nationally funded networks to the proposed new NHS Commissioning Board. However, cross party opposition to the strategy and warnings from leading cancer charities had forced a rethink of the controversial plan.

Mr Lansley had initially stuck by his proposals, which would have seen the NHS Commissioning Board, and not the government, deciding on possible replacement services when GP consortiums take over the bulk of NHS commissioning in 2013.

However, …
Microalbuminuria and Potential Confounders: A review and some observations on variability of urinary albumin excretion
Authors: Carl Erik Mogensen, Else Vestbo, Per Løgstrup Poulsen, Christian Christianse, Else Marie Damsgaar, EiSKjÆtR Hans, Anders Frøland, Klavs Würgler Hansen, Steen Nielsen, Margrethe Mau Pedersen
Journal: Diabetes Care (1995)
Women's perception of obstetric and gynecological examinations.
Authors: J Menage
Journal: BMJ (1993)

drop out (36% with SSRI and 39% with tricyclic antidepressants; p=0-34).Both studies quoted by Hale as showing an advantage of SSRIs over tricyclic antidepressants in long term compliance were placebo controlled, not including tricyclic antidepressants.In summary, there seems little evidence to support the routine first line use of SSRIs.The debate has now shifted to the issues of suicide by overdose and costs.This cannot be resolved by reference to the trial data and will be the subject of a further paper.SmithKline Beecham and Lilly Industries Ltd refer to data from unpublished studies, which therefore cannot be commented on.The burden of proof must lie with those who advocate the use of expensive new drugs on the basis of improved tolerability.
Allogeneic hematopoietic stem-cell transplantation in AML and MDS using myeloablative versus reduced-intensity conditioning: the role of dose intensity
Authors: A Shimoni, I Hardan, N Shem-Tov, M Yeshurun, R Yerushalmi, A Avigdor, I Ben-Bassat, A Nagler
Journal: Leukemia (2005)
VALE EPILATIO. X-Ray Epilation of the Scalp at Goldie Leigh Hospital, Woolwich (1922–58).
Authors: S. COCHRANE SHANKS
Journal: British Journal of Dermatology (1967)

Journal Article VALE EPILATIO. X‐Ray Epilation of the Scalp at Goldie Leigh Hospital, Woolwich (1922–58). Get access S. COCHRANE SHANKS S. COCHRANE SHANKS Formerly Radiologist to Goldie Leigh Hospital, Abbey Wood, London S.E. 2 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 79, Issue 4, 1 April 1967, Pages 237–238, https://doi.org/10.1111/j.1365-2133.1967.tb11480.x Published: 01 April 1967
Familial acquired thrombotic thrombocytopenic purpura: ADAMTS13 inhibitory autoantibodies in identical twins
Authors: Jan-Dirk Studt, Johanna A. Kremer Hovinga, Radovan Radonic, Vladimir Gasparovic, Dragutin Ivanovic, Marijan Merkler, Urs Wirthmueller, Clemens Dahinden, Miha Furlan, Bernhard Lämmle
Journal: Blood (2004)
Correlation of the size of type II transforming growth factor beta (TGF-beta) receptor with TGF-beta responses of isolated bovine articular chondrocytes.
Authors: H L Glansbeek, P M van der Kraan, E L Vitters, W B van den Berg
Journal: Annals of the Rheumatic Diseases (1993)

Transforming growth factor beta (TGF-beta) is a multipotent regulator of cell proliferation and extracellular matrix production. The effect of TGF-beta on chondrocyte matrix production was studied in relation to the expression of TGF-beta binding proteins. The effect of TGF-beta on proteoglycan synthesis of isolated articular chondrocytes depended on the culture period. Proteoglycan synthesis of chondrocytes which were cultured for one day was inhibited by TGF-beta whereas proteoglycan synthesis of chondrocytes cultured in monolayer for seven days or longer was stimulated by TGF-beta. To investigate if this differential response is related to a distinct expression of TGF-beta receptors, this parameter was studied by affinity labelling.Chondrocytes were incubated with 100 pM TGF-beta labelled with iodine-125. Crosslinking was performed using 0.25 mM disuccinimidyl suberate. Membrane proteins were extracted and analysed by denaturating sodium dodecylsulphate polyacrylamide gel electrophoresis (SDS-PAGE) and autoradiography.Freshly isolated and cultured chondrocytes expressed types I, II, and III TGF-beta receptors. The type II TGF-beta receptor of cultured chondrocytes appeared to be about 15 kilodaltons smaller than the type II TGF-beta receptor expressed on freshly isolated chondrocytes, however.As the type II TGF-beta receptors appears to be involved in signal transduction, this change in size of the type II TGF-beta receptor might be related to the differential effect of TGF-beta on proteoglycan synthesis of freshly isolated and cultured bovine articular chondrocytes.
Mass Screening Programs For Sickle Hemoglobin: A Sickle Cell Crisis
Authors: James E. Bowman
Journal: JAMA (1972)

<h3>To the Editor.—</h3> The recent public interest in sickle cell anemia has produced a profusion of spurious sickle cell information by community, social, fraternal, civil rights and black nationalist groups, schools, large business interests, sickle cell anemia foundations, politicians, and by health care workers. Consequently, ill-advised mandatory sickle cell screening laws have been passed<sup>1</sup>; persons with sickle cell trait (HbAS) have been barred from sports by physicians, denied employment, and discharged from jobs; misguided attempts are in progress to defer persons with HbAS from the Armed Forces; children and parents are frantic. Now, an EDITORIAL inThe Journal(221:500, 1972). First, it equates sickle cell trait with sickle cell disease and employs this faulty classification as a rationale for mass sickle cell screening in black communities. Thus, more than 2 million Afro-Americans who have sickle cell trait, and whose life expectancy is comparable to persons who do not have hemoglobin
A 47-Year-Old Woman with Pancreatitis and Early Satiety
Authors: G. A. Lehman, J. Baillie
Journal: Endoscopy (2000)

This month's guest discussant is Dr Glen Lehman, MD, Professor of Medicine at Indiana University Hospital. Dr Lehman is an internationally renowned expert in hepatobiliary and pancreatic disorders, but has wide interests throughout gastroenterology and gastrointestinal endoscopy. He has been a friend and great role model to a generation of aspiring ERCP endoscopists. Welcome, Dr Lehman. Let me present our case ...
SUCCESSFUL TREATMENT OF AIR EMBOLISM
Authors: J. E. Musgrove
Journal: JAMA (1952)

Although fatal air embolism is a relatively rare catastrophe, the frequent use of air injections in diagnostic and therapeutic measures warrants the report of a severe air embolism with successful outcome. <h3>REPORT OF A CASE</h3> W. H., a white man, aged 36, had had bilateral bronchiectasis since childhood. On Sept. 29, 1951, the lower and middle lobes of the right lung were removed. The lower lobe and the lingula of the upper lobe of the left lung were excised on March 15, 1952. Convalescence following this second operation was rather difficult, the remaining upper lobe of the left lung not expanding fully and the patient being dyspneic and unable satisfactorily to raise the bronchial secretions. A pneumoperitoneum seemed indicated to aid his respiratory function. On March 29 a pneumoperitoneum was attempted, with the use of the Zavod "pneumo" apparatus. The patient was lying in the semi-Fowler position, and the needle
Seasonal Variation of Glycemic Control in Type 2 Diabetic Patients
Authors: Hajime Ishii, Hodaka Suzuki, Tsuneharu Baba, Keiko Nakamura, Tsuyoshi Watanabe
Journal: Diabetes Care (2001)

Medical nutrition therapy is integral to diabetes care and management (1). Balance between dietary intake and energy consumption through daily physical activities is the most influential factor in the glycemic control of type 2 diabetic patients. The nutritional prescription made for a diabetic individual is usually determined by taking into consideration the expected physical activity, diabetes complication(s), and age. The dietary advice based on this prescription seems to be valid in many cases for at least a …
Run-in Periods in Randomized Trials
Authors: Ariel Pablos-Méndez, R. Graham Barr, Steven Shea
Journal: JAMA (1998)

Prerandomization run-in periods are being used to select or exclude patients in an increasing number of clinical trials, but the implications of run-in periods for interpreting the results of clinical trials and applying these results in clinical practice have not been systematically examined. We analyzed illustrative examples of reports of clinical trials in which run-in periods were used to exclude noncompliant subjects, placebo responders, or subjects who could not tolerate or did not respond to active drug. The Physicians' Health Study exemplifies the use of a prerandomization run-in period to exclude subjects who are nonadherent, while recent trials of tacrine for Alzheimer disease and carvedilol for congestive heart failure typify the use of run-in periods to exclude patients who do not tolerate or do not respond to the study drug. The reported results of these studies are valid. However, because the reported results apply to subgroups of patients who cannot be defined readily based on demographic or clinical characteristics, the applicability of the results in clinical practice is diluted. Compared with results that would have been observed without the run-in period, the reported results overestimate the benefits and underestimate the risks of treatment, underestimate the number needed to treat, and yield a smaller P value. The Cardiac Arrhythmia Suppression Trial exemplifies the use of an active-drug run-in period that enhances clinical applicability by selecting a group of study subjects who closely resembled patients undergoing active clinical management for this problem. Run-in periods can dilute or enhance the clinical applicability of the results of a clinical trial, depending on the patient group to whom the results will be applied. Reports of clinical trials using run-in periods should indicate how this aspect of their design affects the application of the results to clinical practice.
Apoptosis and Loss of Renal Tissue in Polycystic Kidney Diseases
Authors: David Woo
Journal: New England Journal of Medicine (1995)

Polycystic kidney disease is characterized by the enlargement of renal cysts, interstitial fibrosis, and gradual loss of normal renal tissue in association with progressive deterioration of renal function. The process causing the progressive loss of renal tissue is unknown, but it could be the result of a form of programmed cell death known as apoptosis.We assayed apoptotic DNA fragmentation in normal and polycystic kidneys biochemically by gel electrophoresis and histochemically by in situ end-labeling. A DNA-specific dye, Hoechst 33258, was used to detect morphologic apoptosis in renal samples from patients with normal kidneys, polycystic kidney disease, and other kidney diseases.Apoptotic DNA fragmentation was detected in polycystic kidneys from 5 patients without renal failure and 11 patients with renal failure but not in kidneys from 12 patients with no renal disease. In situ end-labeling revealed apoptotic cells in glomeruli, in cyst walls, and in both cystic and noncystic tubules of the polycystic kidneys. No tubular apoptosis was detected in renal-biopsy specimens from five patients with IgA nephropathy, three patients with nephrosclerosis, two patients with focal glomerulosclerosis, one patient with diabetic nephropathy, six patients with acute tubular necrosis, or four patients with acute and four patients with chronic renal-transplant rejection. The capacity of polycystic kidney cells to undergo apoptosis was retained in vitro in the absence of uremia, ischemia, and other confounding pathologic conditions.Apoptotic loss of renal tissue may be associated with the progressive deterioration of renal function that occurs in patients with polycystic kidney disease.
Ozone enhances markers of innate immunity and antigen presentation on airway monocytes in healthy individuals
Authors: John C. Lay, Neil E. Alexis, Steven R. Kleeberger, Robert A.S. Roubey, Bradford D. Harris, Philip A. Bromberg, Milan J. Hazucha, Robert B. Devlin, David B. Peden
Journal: Journal of Allergy and Clinical Immunology (2007)
Functional, molecular and proteomic characterisation of bone marrow mesenchymal stem cells in rheumatoid arthritis
Authors: M-C Kastrinaki, P Sidiropoulos, S Roche, J Ringe, S Lehmann, H Kritikos, V-M Vlahava, B Delorme, G D Eliopoulos, C Jorgensen, P Charbord, T Haupl, D T Boumpas, H A Papadaki
Journal: Annals of the Rheumatic Diseases (2007)

Bone marrow (BM) mesenchymal stem cells (MSCs) are being considered as potential therapeutic agents in various inflammatory autoimmune diseases for their tissue-repair and anti-inflammatory tissue-protective properties. This study investigates the reserves and function, the molecular and proteomic profile and the differentiation potential of BM MSCs in patients with active rheumatoid arthritis (RA).We evaluated the frequency of MSCs in the BM mononuclear cell fraction using a limiting dilution assay, the proliferative/clonogenic potential and the capacity of cells to differentiate towards the osteogenic/chondrogenic/adipogenic lineages using appropriate culture conditions. We also assessed the molecular and proteomic characteristics in terms of inflammatory cytokine gene and protein expression, the relative telomere length and the survival characteristics of BM MSCs.MSCs from patients with RA (n = 26) and age- and sex-matched healthy individuals (n = 21) were similar in frequency, differentiation potential, survival, immunophenotypic characteristics, and protein profile. Patient MSCs, however, had impaired clonogenic and proliferative potential in association with premature telomere length loss. Transcriptome analysis revealed differential expression of genes related to cell adhesion processes and cell cycle progression beyond the G1 phase. Previous treatment with methotrexate, corticosteroids, anti-cytokine and biological agents or other disease-modifying anti-inflammatory drugs did not correlate with the clonogenic and proliferative impairment of BM MSCs.In spite of some restrictions related to the impaired clonogenic and proliferative potential, our findings support the use of autologous BM MSCs in RA and may have important implications for the ongoing efforts to repair tissue injury commonly seen in the course of the disease.
Pyloroplasty and Vagotomy for Duodenal Ulcer
Authors: Wilfred T. Small, Mian Ashraf
Journal: New England Journal of Medicine (1965)

VARIOUS surgical procedures for the complications of duodenal ulcer are frequently being re-evaluated. Pyloroplasty and vagotomy is one of these, and the first 110 consecutive operations performed at the Memorial Hospital, Worcester, form the basis of this report. The appeal of this procedure is a stomach intact and in continuity. Theoretically, the cephalic phase of gastric stimulation is muted or abolished by truncal vagotomy. Pyloroplasty, which destroys the function of the pylorus but encourages easy gastric emptying, prevents antral stimulation by stasis and the ensuing local pressure. The stomach, as far as can be determined in most cases, is undiseased . . .
What We Have Learned from the Toad Concerning Hypophyseal Functions
Authors: BERNARDO A. HOUSSAY
Journal: New England Journal of Medicine (1936)

THERE are three reasons which justify the dedication of my first lecture to such a hum- ble living creature as the toad: (1) because, more than twenty-five years ago, my first pub- lication in Physiology was on the pituitary of amphibians; (2) because the toad is the species in which the largest number of functions related to the pituitary has been found and studied; and (3) because hormonal actions are not species specific, but have a fundamental similarity
Increased glycosaminoglycan accumulation as a genetic characteristic in cell cultures of one variety of dominant dystrophic epidermolysis bullosa.
Authors: E A Bauer, W K Fiehler, N B Esterly
Journal: Journal of Clinical Investigation (1979)

Fibroblast cultures from patients with dominant dystrophic epidermolysis bullosa of the albopapuloid variety display deranged glycosaminoglycan metabolism. These cells accumulate increased amounts of sulfated glycosaminoglycans. The mechanism for the greater content of glycosaminoglycans appears to be related to increased synthesis. During the first 6-12 h, intracellular labeled glycosaminoglycans accumulated in the dominant dystrophic epidermolysis bullosa cells at about twice the rate as that of control fibroblasts. In addition, secretion of sulfated glycosaminoglycans was two- to threefold greater than in control cultures. In contrast, both pulse-chase and cross-correction experiments failed to show any evidence for defective degradation of the material. The biochemical trait is genetically specific for albopapuloid dominant dystrophic epidermolysis bullosa, since fibroblasts from patients with other varieties of epidermolysis bullosa did not accumulate increased glycosaminoglycans. The data suggest that in vitro abnormality in glycosaminoglycan metabolism could serve as an important marker for this variety of epidermolysis bullosa and be of genetic and prognostic value in the sporadic patient with epidermolysis bullosa. Although the precise relationship of the defect to the disease has not yet been defined, it is possible that excessive tissue accumulation of glycosaminoglycans may alter collagen fibril deposition, thus, impairing the structural integrity of the skin and leading to posttraumatic blisters and erosions that characterize the disease.
Health and Science Policies — A Look Ahead
Authors: Daniel S. Greenberg
Journal: New England Journal of Medicine (1978)

In the bureaucracies that are responsible here for the government's dealings with health-care and scientific research, there is a strong measure of gloom about what lies ahead in the new year.The reason is that the political lesson that has been generally extracted from the November elections is that the voters are displeased with the performance of government, weary of its costs and altogether want less of it. Add to this the holy war that Mr. Carter has declared against inflation and federal deficits, and the effect is heavily dampening. It could be argued, of course, that the true meaning . . .