Fibrolamellar Hepatocellular Carcinoma
Authors: Mark T. Ruffin
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 October 1988Fibrolamellar Hepatocellular CarcinomaMark T. Ruffin IV, MDMark T. Ruffin IV, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-7-596 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: The article on hepatocellular carcinoma (1) provided an excellent update and review of the relevant epidemiology, etiology, diagnosis, and treatment. The discussion of screening and early diagnosis was extremely helpful to those of us caring for refugees from areas of high incidence of hepatocellular carcinoma. However, the authors did not discuss a unique subset of the disease, fibrolamellar hepatocellular carcinoma, which has unique pathologic characteristics and differs from classic hepatocellular carcinoma in several areas.The histopathologic features of fibrolamellar hepatocellular carcinoma are deeply eosinophilic hepatocytes, many of which contain intracytoplasmic hyaline globules, and distinct pale bodies (2-4)....References1. Di BisceglieRustgiHoofnagleDusheikoLotze AVJGM. Hepatocellular carcinoma. Ann Intern Med. 1988;108:390-401. LinkGoogle Scholar2. CraigPetersEdmonsonOmata JRHM. Fibrolamellar carcinoma of the liver: a tumor of adolescents and young adults with distinctive clinico-pathologic features. Cancer. 1980;7:462-502. Google Scholar3. BermanLibbeyFoster MNJ. Hepatocellular carcinoma: polygonal cell type with fibrous stroma—an atypical variant with a favorable prognosis. Cancer. 1980;46:1448-55. CrossrefMedlineGoogle Scholar4. FarhiShikesSilverberg DRS. Ultrastructure of fibrolamellar oncocyte hepatoma. Cancer. 1982;50:702-9. CrossrefMedlineGoogle Scholar5. ParadinasMeliaWilkinson JW. High serum vitamin B12 binding as a marker of fibrolamellar variant of hepatocellular carcinoma. Br Med J. 1982;285:840-2. CrossrefMedlineGoogle Scholar6. CollierBloomHodgsonWeinbrenLeeBlumgert NDHKYL. Neurotensin secretion by fibrolamellar carcinoma of the liver. Lancet. 1984;15:538-40. CrossrefGoogle Scholar7. LefkowitchMuschelPriceMarboeBraunhut JRJCS. Copper and copper-binding protein in fibrolamellar liver cell carcinoma. Cancer. 1983;51:97-100. CrossrefMedlineGoogle Scholar8. AdamGibsonSoreide RRO. The radiology of fibrolamellar hepatoma. Clin Radiol. 1986;37:355-8. CrossrefMedlineGoogle Scholar9. FriedmanLichtensteinGoodmanFishmanSiegelmanDachman AJZESA. Fibrolamellar hepatocellular carcinoma. Radiology. 1985;157:583-7. CrossrefMedlineGoogle Scholar10. FrancisAghaThompsonKaren IFND. Fibrolamellar hepatocellular carcinoma: Clinical, radiologic and pathologic features. Gastrointest Radiol. 1986;11:67-72. CrossrefMedlineGoogle Scholar11. StarziIwatsukiShawNalesnikFarhiVan Thiel TSBMDD. Treatment of fibrolamellar hepatoma with partial or total hepatectomy and transplantation of the liver. Surg Gynecol Obstet. 1986;162:145-8. MedlineGoogle Scholar12. NagorneyAdsonWeilandKnightSmalleyZinsmeister DMLCSA. Fibrolamellar hepatoma. Am J Surg. 1985;149:133-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEuropean Cases of Fibrolamellar Hepatocellular CarcinomaA. Bassa Malondra, MD, PhD, M. Fiol Picornell, MD, J. Terrasa Pons, MD, J.J. Torres Rovira, MD, J. Buades Reines, MD, PhD 1 October 1988Volume 109, Issue 7Page: 596-597KeywordsEpidemiologyEtiologyHepatocellular carcinomaHepatocytes Issue Published: 1 October 1988 PDF downloadLoading ...