tbuckley/cabot-search huggingface dataset:
Computer-Aided Cognitive Behaviour Therapy
Authors: L. Baer, J. Greist, I.M. Marks
Journal: Psychotherapy and Psychosomatics (2007)

Dropout rates soar, however, if Internet access to CCBT is open and unmonitored [1] . The coming of age of CCBT as a way of delivering mental health care was recently recognized by its first approval by a government agency. That approval came from the National Institute for Clinical Excellence (NICE), the English regulatory body. NICE [3] now recommends 2 CCBT systems for the National Health Service – Beating the Blues for depression and FearFighter for panic and phobic disorders. Few CCBT systems have dealt with obsessive-compulsive disorder (OCD). There have been case reports of CCBT with OCD [4, 5] and a pilot study of vicarious exposure by CCBT [6, 7] . Most CCBT research on OCD so far has concerned the BTSteps (Behavior Therapy Steps) system [8] , which Tumur et al. [9] and McCrone et al. [10] refer to in this issue. The BTSteps system delivers its CCBT by telephone via a computer-driven interactive voice response (IVR) system which helps the user plan and carry out the selfdirected exposure and ritual prevention that are core features of effective CBT for OCD. The patient directs the computer IVR interview by key presses on the phone, usually at home and mostly outside usual working hours. (In Britain BTSteps has been adapted for use at home on the Internet and is available under the name OCFighter to avoid confusion with a well-known telephone company). Worldwide the demand for cognitive behaviour therapy (CBT) exceeds the availability of therapists. This gap and advances in information technology have catalyzed a rich ferment of research into computer-aided CBT (CCBT). Certain CCBT systems can save much therapist time by allowing most treatment tasks to be delegated to patient-computer interactions. In contrast, therapist time is not saved either by conducting CBT via email, telephone or videoconference exchanges between patient and therapist in real time, or via most virtual reality systems. CCBT also provides guidance personalized to each patient yet perfectly standardized given the same series of patient responses. Fully 175 CCBT studies including 87 randomized controlled trials (RCTs) have just been reviewed in a Maudsley Monograph [1] , and in this journal Emmelkamp [2] discussed technological innovations in psychotherapy including CCBT. The 97 CCBT systems reviewed in the Monograph concerned a wide spectrum of mental health problems. A growing number of CCBT systems are becoming available on the Internet. Users of CCBT on the Internet are more likely to complete it if they are first screened, are then given access by a password, and are then supported briefly by phone, email or face to face.
Abstract 4096: Correction of metabolically sensitive histone epigenetic marks mediates the drug sensitivity of MDA-MB-231 human breast cancer cells
Authors: Natalie E. Simpson, Igor P. Pogribny, Frederick A. Beland
Journal: Cancer Research (2012)

Abstract Evidence is accumulating that epigenetic alterations are major determinants of breast cancer progression. In a previous study we demonstrated that specific patterns of histone modifications correlated with changes in histone modifying enzymes in human breast cancer cells. More importantly, these changes were metabolically sensitive and differed between cells with epithelial and mesenchymal phenotypes, suggesting that they can be used as diagnostic and prognostic epigenetic biomarkers for breast cancer progression. We have now investigated whether or not metabolic targeting of the epigenome may be used for the treatment of breast cancer. Exposure of breast cancer cells to Compound 968, an allosteric inhibitor of glutaminase (GLS1), which we demonstrated previously to increase global histone H4 lysine 16 acetylation levels in mesenchymal MDA-MB-231 cells versus epithelial T-47D cells, resulted in a marked inhibition of cancer cell growth, with the effects being more prominent in mesenchymal MDA-MB-231 cells than epithelial T-47D cells. The growth inhibitory effect of Compound 968 in MDA-MB-231 breast cancer cells was accompanied by modest changes in H4 lysine 16 acetylation and a decreased level of histone H4 lysine 20 trimethylation at the promoter of tumor suppressor genes (e.g., CDH1), with a concordant rise in expression of the transcriptionally silenced CDH1 gene. Although, Compound 968 did not restore fully CDH1 expression in MDA-MB-231 to the level observed in epithelial T-47D cells, the observed increase in expression may lead to formation of a less aggressive cancer phenotype in MDA-MB-231 cancer cells and increase their sensitivity to chemotherapeutic agents. Indeed, a combined treatment of Compound 968 and the conventional chemotherapeutic drug cisplatin substantially increased the sensitivity of MDA-MB-231 cells to cisplatin. These results indicate that correcting of cancer-related metabolic disturbances may be an effective method for the targeted treatment of the cellular epigenome in aggressive breast cancer and may be useful for improving of the clinical management of breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4096. doi:1538-7445.AM2012-4096
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia
Authors: Rajani K. Vangala, Marion S. Heiss-Neumann, Janki S. Rangatia, Sheo M. Singh, Claudia Schoch, Daniel G. Tenen, Wolfgang Hiddemann, Gerhard Behre
Journal: Blood (2002)
Antiarrhythmic Drug Therapy for Sustained Ventricular Arrhythmias Complicating Acute Myocardial Infarction
Authors: Jonathan P. Piccini
Journal: Circulation (2009)

Abstract #2363 Jonathan P. Piccini, Phillip J. Schulte, Karen S. Pieper, Rajendra H. Mehta, Duke Clinical Res Inst, Durham, NC; Eric J. Topol, Scripps Translational Science Inst, La Jolla, CA; Harvey D. White, Auckland City Hosp, Auckland, New Zealand; Frans Van de Werf, Univ Hosp Leuven, Leuven, Belgium; Diego Ardissino, Univ of Parma, Parma, Italy; Robert M. Califf, Christopher B. Granger, E. Magnus Ohman, John H. Alexander, Duke Clinical Res Inst, Durham, NC Jonathan P. Piccini, 2009 Finalist and Presenting Author
Abstract 2411: Intratumoral dendritic cell vaccine as neo-adjuvant immunotherapy of high-risk soft tissue sarcoma patients undergoing external beam radiation therapy (EBRT): Prospective phase I/II clinical trial
Authors: Cristina Iclozan, Steven E. Finkelstein, Jamil Ahmed, Marilyn M. Bui, Matthew J. Cotter, Rupal Ramakrishnan, David Cheong, Ricardo J. Gonzalez, Randy V. Heysek, Brianna C. Lenox, Vernon K. Sondak, Rosemary R. Szekely, Jonathan S. Zager, G. Douglas Letson, Scott J. Antonia, Dmitry I. Gabrilovich
Journal: Cancer Research (2010)

Abstract Cell death inducing external beam radiation (EBRT) combined with experimental intratumoral injection of dendritic cells (DC) showed promise by initiating anti-autologous tumor-cell immune responses in mice. Here we performed first clinical trial testing this hypothesis in patients with large high-grade soft tissue sarcomas (STS). This type of cancer has a significant (&amp;gt;50%) risk of progressing to distant metastases. Patients with clinical stage T2N0M0 or T3N0M0 high-grade STS of the extremity/trunk/chest wall were treated with standard neo-adjuvant EBRT 5040 cGy / 180 cGy coordinated with experimental DC therapy consisting of DC progenitor apheresis, ex-vivo expansion and culture, and 4 × intratumoral injections of 10 million DC. Autologous DC product was performed according to standardized GMP laboratory procedures. T cell function was assessed by EliSpot (measuring IFN-γ production) and proliferation (thymidine uptake) in addition to phenotyping of peripheral blood mononuclear cells by flow cytometry. Clinically, targeted accrual was reached with eighteen patients completing neo-adjuvant EBRT with experimental intratumoral DC therapy. All patients have completed full immunologic assessment. Ten patients (56%) were induced to produce significant immune responses against autologous tumor cell lysates or/and survivin antigens as determined using ELISPOT assays or cell proliferation. Interestingly, some of these responses persisted even 30 weeks after start of treatment. Extensive post treatment T cell infiltration was detected within tumors. No clinical toxicity has been observed. Suggestive clinical outcome on 14 patients followed 1 year reveal progress in 1/7 patients with robust response (detected at more than one time point), and 4/7 patients with weak (detected at one time point at the beginning of the study) or no response respectively. Thus, this data is promising for planning future combined treatment approaches as radiation therapy/immunotherapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2411.
VEGFR-3 is expressed on megakaryocyte precursors in the murine bone marrow and plays a regulatory role in megakaryopoiesis
Authors: Wilko Thiele, Jaya Krishnan, Melanie Rothley, Debra Weih, Diana Plaumann, Vanessa Kuch, Luca Quagliata, Herbert A. Weich, Jonathan P. Sleeman
Journal: Blood (2012)
Obstructive Syndrome Due to a Bezoar in a B-II Gastric Stump. Endoscopic Treatment
Authors: S. Ishioka, P. Sakai, O. E. C. Regis, U. L. Filho, H. W. Pinotti
Journal: Endoscopy (1983)

Three cases of a phytobezoar in B-II-gastrectomy are considered in relation to their development around a suture thread acting as precipitating factor; the bezoar was responsible for the presenting obstructive syndrome. Endoscopic diagnosis and definitive treatment by removal of the bezoar together with the thread after cutting the fixed end is stressed. Various kinds of treatment proposed by other authors for the common types of bezoar are discussed.
MULTIPLE ABSCESSES OF THE OMENTUM.REPORT OF TWO CASES.
Authors: HUGO O. PANTZER
Journal: JAMA (1904)

Under the title of "Das Netz als Schutzorgan," E. de Renzi and G. Boeri<sup>1</sup>of the first medical clinic of the University of Naples, publish the results of experimental researches. Like von Becklinghausen, Bizzozzero and others, they have demonstrated a striking similarity in contrasting the function of the omentum with the lymph system, in its activity in the absorption of substances from the peritoneal cavity. The attraction of the omentum to the site of injury, foreign body or inflammation, in its endeavor to protect the abdominal cavity, is well known. Experimentally, by these men, it is shown that in young animals, after the removal of the omentum, there is retardation in general development, and in adults their susceptibility to abdominal infection is markedly increased after the removal of the omentum. After the circulation in certain viscera, notably the spleen, has been impaired by the ligation of the afferent or efferent
Augmentation of Left Ventricular Wall Thickness With Alginate Hydrogel Implants Improves Left Ventricular Function and Prevents Progressive Remodeling in Dogs With Chronic Heart Failure
Authors: Hani N. Sabbah, Mengjun Wang, Ramesh C. Gupta, Sharad Rastogi, Itamar Ilsar, Michael S. Sabbah, Smita Kohli, Sam Helgerson, Randall J. Lee
Journal: JACC Heart Failure (2013)
Cross-infection in a surgical unit.
Authors: P A Pompa, A D Caldwell
Journal: BMJ (1967)

draws attention to the importance of pain in the tongue as a feature in giant cell arteritis.We have found glossitis in 12.6% of a series of 87 cases of temporal arteritis.''The glossitis varied from gangrene of the anterior two-thirds of the tongue to a sensa- tion of burning.Commonly the tongue was raw-beef red and sore.There were also examples of blistering and bruising, and this, together with the pathogenesis of other skin lesions in giant cell arteritis, has led us to suppose that in vascular areas such as the tongue, scalp, and face necrosis is due to haemorrhage rather than occlusion.'We agree with Dr. Henderson that the tongue should be examined in every case where giant cell arteritis is suspected, as it may present important confirmatory evidence.-We are, etc., P. D. C. KINMONT.Derby.
Behavior of cardiac receptors with nonmyelinated vagal afferents during spontaneous respiration in cats.
Authors: M D Thames, D E Donald, J T Shepherd
Journal: Circulation Research (1977)

Activity from left atrial and left ventricular receptors with nonmyelinated vagal afferents (mean conduction velocity, 1.2 m/sec) was recorded in 13 closed-chest spontaneously breathing cats anesthetized with alpha-chloralose. The anatomic position of each receptor was determined by probing the opened heart at the conclusion of the experiment. Three of eight left atrial receptors and four of five left ventricular receptors were silent under resting conditions. The mean discharge frequency under resting conditons for the six receptors displaying spontaneous activity was 1.0 +/- 0.15 impulse/sec. Thus cardiac receptors with vagal nonmyelinated afferent have a low resting discharge in spontaneously breathing cats. The frequency and pattern of discharge of atrial but not of ventricular receptors was altered during spontaneous respiration. The atrial receptors discharged with cardiac rhythmicity during end inspiration and early expiration when transmural pressure was greatest and were silent for the remainder of the respiratory cycle. Whe respiration was augmented by CO2 breathing or blood volume was increased, the rate of discharge was a linear function of atrial transmural pressure. Eleven ventricular receptors with nonmyelinated afferents (mean conduction velocity, 1.0 m/sec) were exposed to graded volume expansion and phenylephrine infusion in eight open-chest and three spontaneously breathing cats. Raising left ventricular end-diastolic pressure alone increased the frequency of discharge, and a concomitant increase in systolic pressure caused a further increase in firing.
Beta 2-microglobulin and its binding activity in serum from patients with SLE.
Authors: P.E Evrin, T Ström
Journal: Annals of the Rheumatic Diseases (1984)

Repeated determinations of beta 2-microglobulin (beta 2m) and beta 2-microglobulin binding activity (beta 2m ba) in serum were performed during a follow-up of 23 patients with SLE. beta 2m was determined by a radioimmunoassay. Individual mean values were raised in 65% of the patients. The mean value for all patients, 2.9 mg/l, was significantly higher than that of the controls. The beta 2m concentrations parallelled the clinical disease activity in several cases with different disease manifestations. The beta 2m ba was determined by precipitation of 125I-labelled beta 2m with polyethylene glycol. Increased beta 2m ba was found in 26% of the SLE patients with the 90th percentile in 40 healthy subjects being taken as the upper normal limit. There were, however, no significant differences between the mean values for beta 2m ba in the patients and the controls. Patients with systemic lupus erythematosus (SLE), suffering exacerbation of their disease, had a higher mean beta 2m ba than those with less active disease. Variations of the serum beta 2m ba occurred especially in patients with active disease but did not seem to reflect the clinical course. The beta 2m ba was recovered in the IgG peak when SLE serum was subjected to gel chromatography on Sephadex G-200.
Forest Fire Smoke Exposures and Out-of-Hospital Cardiac Arrests in Melbourne, Australia: A Case-Crossover Study
Authors: Martine Dennekamp, Lahn D. Straney, Bircan Erbas, Michael J. Abramson, Melita Keywood, Karen Smith, Malcolm R. Sim, Deborah C. Glass, Anthony Del Monaco, Anjali Haikerwal, Andrew M. Tonkin
Journal: Environmental Health Perspectives (2015)

Millions of people can potentially be exposed to smoke from forest fires, making this an important public health problem in many countries.In this study we aimed to measure the association between out-of-hospital cardiac arrest (OHCA) and forest fire smoke exposures in a large city during a severe forest fire season, and estimate the number of excess OHCAs due to the fire smoke.We investigated the association between particulate matter (PM) and other air pollutants and OHCA using a case-crossover study of adults (≥ 35 years of age) in Melbourne, Australia. Conditional logistic regression models were used to derive estimates of the percent change in the rate of OHCA associated with an interquartile range (IQR) increase in exposure. From July 2006 through June 2007, OHCA data were collected from the Victorian Ambulance Cardiac Arrest Registry. Hourly air pollution concentrations and meteorological data were obtained from a central monitoring site.There were 2,046 OHCAs with presumed cardiac etiology during our study period. Among men during the fire season, greater increases in OHCA were observed with IQR increases in the 48-hr lagged PM with diameter ≤ 2.5 μm (PM2.5) (8.05%; 95% CI: 2.30, 14.13%; IQR = 6.1 μg/m(3)) or ≤ 10 μm (PM10) (11.1%; 95% CI: 1.55, 21.48%; IQR = 13.7 μg/m(3)) and carbon monoxide (35.7%; 95% CI: 8.98, 68.92%; IQR = 0.3 ppm). There was no significant association between the rate of OHCA and air pollutants among women. One hundred seventy-four "fire-hours" (i.e., hours in which Melbourne's air quality was affected by forest fire smoke) were identified during 12 days of the 2006/2007 fire season, and 23.9 (95% CI: 3.1, 40.2) excess OHCAs were estimated to occur due to elevations in PM2.5 during these fire-hours.This study found an association between exposure to forest fire smoke and an increase in the rate of OHCA. These findings have implications for public health messages to raise community awareness and for planning of emergency services during forest fire seasons.
Meeting millennium development goals 3 and 5
Authors: Bertha Nhlema Simwaka, Sally Theobald, Yaa Peprah Amekudzi, Rachel Tolhurst
Journal: BMJ (2005)

Gender equality needs to be put on the African agenda 

A recent World Health Organization report warns that the health related millennium development goals (MDGs) will not be met without a dramatic increase in investments in national health systems.1 Assessments of progress towards the goals to date have found that we have made the least progress towards MDG 5—to improve maternal health—particularly in sub-Saharan Africa. In some African countries the situation has got worse; maternal mortality in Malawi has almost doubled between 1992 and 2000 despite increased resources for health.2 Women's lifetime risk of pregnancy related death in Malawi is now 1 in 7, compared with 1 in 2800 in industrialised countries.3 It is critical and timely to lobby for more resources, but this is insufficient without attention to the issues of gender and power which underlie maternal morbidity and mortality, both within communities and within health systems.

Every minute, a woman dies in pregnancy or childbirth.4 Nearly half of these deaths (47%) …
Submarine Medicine — An Occupational Specialty
Authors: Harry J. Alvis
Journal: New England Journal of Medicine (1957)

SUBMARINE medicine as a specialty began to take form within the United States Navy over a quarter of a century ago. Official recognition of specially trained medical officers by a new designation was given, and authority to wear a distinguishing insigne was established during World War II. A division of submarine medicine in the Bureau of Medicine and Surgery and a plan of training were established a decade ago. Comparison with the simultaneous evolution of occupational medicine in civilian practice clearly demonstrates that submarine medicine is a highly developed area of the broad pattern of occupational medicine. Nowhere else does . . .
Charity condemns child survival “lottery”
Authors: Peter Moszynski
Journal: BMJ (2008)

Ten million children under 5 years old die each year across the world, warns Save the Children in a new campaign aimed at getting countries back on target to achieve the millennium development goal to reduce mortality in under 5s by two thirds by 2015. 

The charity has compiled a “wealth and survival index” that compares child mortality in each country with its national income per person. It claims that the index shows “who is making the most of what they have and who is squandering their resources.”

Its director of policy, David Mepham, said, “A child’s chance of making it to its fifth birthday depends …
Physicians Should be Compensated.
Authors: Arthur V. Meigs
Journal: JAMA (1898)

Philadelphia, Pa., Feb. 18, 1898. <h3>To the Editor:</h3> —The editorial in the number of yourJournalfor February 12 upon the subject of "notification of contagious diseases" is very timely. I have never been able to understand why physicians should be forced to make notification of contagious disease without compensation, as is commonly done in this country. In England physicians are paid two shillings and six pence each time they give notice of a case of contagious disease in their private practice, and one shilling if the case occurs in a public institution. This is provided by law. It seems contrary to fundamental justice, if not to law, that the medical profession should be made to perform labor without compensation, and I have often wondered whether the courts would not sustain a resistance of it. Respectfully yours,
Molecular Insights into Hypertrophic Cardiomyopathy
Authors: Gregory D. Curfman
Journal: New England Journal of Medicine (1992)

Although sporadic descriptions of hypertrophic cardiomyopathy were published as early as 1869 in France1 and 1907 in Germany,2 it was not until the mid-20th century that a comprehensive picture of this disorder began to take shape.3 4 5 In the ensuing four decades, hypertrophic cardiomyopathy has been a trial and a tribulation to researchers and clinicians alike. The trial has been to discern the cause of the often prodigious cardiac hypertrophy, the hallmark of the disorder; the tribulation, to care for afflicted patients, typically young people who are at risk of dying suddenly before reaching the prime of life.6 Recent inquiries into . . .
Safety and activity of alisertib, an investigational aurora kinase A inhibitor, in patients with breast cancer, small-cell lung cancer, non-small-cell lung cancer, head and neck squamous-cell carcinoma, and gastro-oesophageal adenocarcinoma: a five-arm phase 2 study
Authors: Bohuslav Melichar, Antoine Adenis, A Craig Lockhart, Jaafar Bennouna, E Claire Dees, Omar Kayaleh, Radka Obermannova, Angela DeMichele, Petr Zatloukal, Bin Zhang, Claudio Dansky Ullmann, Claudia Schusterbauer
Journal: The Lancet Oncology (2015)
Plant food allergens homologous to pathogenesis‐related proteins
Authors: Christof Ebner, Karin Hoffmann‐Sommergruber, Heimo Breiteneder
Journal: Allergy (2001)

In general, pathogenesis‐related (PR) proteins are expressed by plants in response to stress conditions like infection, exposure to certain chemicals, wounding and environmental conditions. In some plant tissues, however, PR proteins are constitutively expressed, e.g. in pollens or fruits, tissues that are more likely to be attacked (by insects or fungi) or exposed to atmospheric conditions (e.g. UV irradiation). PR proteins display multiple effects within the plant and possess antimicrobial activity, and can thus be regarded as a part of the plant's defense system. Analyzing known amino acid sequences and functions of characterized (cloned) food allergens, it is remarkable that many of these molecules can be classified as PR proteins. Many PR proteins are stable at low pH, and display considerable resistance to proteases, requirements to act as food allergens. According to sequence characteristics and their enzymatic or biologic activity, PR proteins can be divided into 14 groups. Seven of these 14 groups contain proteins with allergenic properties, six groups contain food allergens.