tbuckley/cabot-search huggingface dataset:
Selective pulmonary vasodilation by inhaled nitric oxide is due to hemoglobin inactivation.
Authors: S Rimar, C N Gillis
Journal: Circulation (1993)

BACKGROUND Inhaled nitric oxide gas selectively decreases pulmonary artery pressure without affecting systemic arterial pressure. To determine if the selective pulmonary vasodilating effect of inhaled nitric oxide gas is due to inactivation by hemoglobin, we studied the ability of whole blood to inhibit the vasodilator activity of effluent from isolated lungs exposed to inhaled nitric oxide. METHODS AND RESULTS The effluent from ventilated, Krebs-perfused rabbit lungs was passed directly over 3- to 4-mm rabbit aortic rings. Inhaled nitric oxide (150 ppm for 3 minutes) reduced pulmonary perfusion pressure, elevated by a continuous infusion of U46619, by 35 +/- 7% (mean +/- SEM, n = 5). Lung effluent from this series of experiments caused 40 +/- 13% relaxation of phenylephrine-preconstricted aortic rings. When blood was added to the combined lung/ring perfusion cascade (final hemoglobin concentration, 1 g/dL), inhaled nitric oxide again significantly reduced pulmonary perfusion pressure, but the effluent now failed to relax the aortic rings (30 +/- 6% [control] versus 1.5 +/- 1% [blood]). Both reduction in pulmonary perfusion pressure and relaxation of the rings during nitric oxide exposure were unchanged from control values after discontinuing the blood infusion. CONCLUSIONS The presence of hemoglobin, even in extremely small amounts, restricts the vasodilating effect of inhaled nitric oxide gas to the pulmonary circulation.
Commercial Filming of Patient Care Activities in Hospitals
Authors: Joel M. Geiderman
Journal: JAMA (2002)

Commercial filming of patient care activities is common in hospital settings. This article reviews common circumstances in which patients are commercially filmed, explores the potential positive and negative aspects of filming, and considers the ethical and legal issues associated with commercial filming of patients in hospital settings. We examine the competing goals of commercial filming and the duties of journalists vs the rights of patients to privacy. Current standards and recommendations for commercial filming of patient care activities are reviewed and additional recommendations are offered.
The BMJ statins papers misrepresent the facts
Authors: P. Sever
Journal: BMJ (2014)

I fully support Rory Collins’s request that The BMJ retracts Abramson and colleagues’ and Malhotra’s papers.1 2 3 The authors totally misrepresent Zhang and colleagues’ claims that statins were causally related to side effects in 20% of statin users.4 The two papers also imply that these side effects were not reported in trials because trial sponsors could have influenced the results and downplayed the …
Alcohol-induced alterations in hepatic microtubule dynamics can be explained by impaired histone deacetylase 6 function
Authors: Blythe D. Shepard, Rohan A. Joseph, George T. Kannarkat, Tara M. Rutledge, Dean J. Tuma, Pamela L. Tuma
Journal: Hepatology (2008)

Abstract We have been using polarized, hepatic WIF-B cells to examine ethanol-induced liver injury. These cells polarize in culture and maintain numerous liver-specific activities including the ability to metabolize alcohol. Previously, we found that microtubules were more highly acetylated and more stable in ethanol-treated WIF-B cells and that increased microtubule acetylation required ethanol metabolism and was likely mediated by acetaldehyde. This study was aimed at identifying the mechanism responsible for increased microtubule acetylation. We examined the expression of two known microtubule deacetylases, histone deacetylase 6 (HDAC6) and Sirtuin T2 (SirT2), in WIF-B cells. Immunoblotting, immunofluorescence microscopy, and assays using the SirT2 inhibitor nicotinamide revealed that WIF-B cells do not express SirT2. In contrast, HDAC6 was highly expressed in WIF-B cells. Addition of trichostatin A (TSA), an HDAC6 inhibitor, induced microtubule acetylation to the same extent as in ethanol-treated cells (approximately threefold). Although immunofluorescence labeling revealed that HDAC6 distribution did not change in ethanol-treated cells, immunoblotting showed HDAC6 protein levels slightly decreased. HDAC6 solubility was increased in nocodazole-treated cells, suggesting impaired microtubule binding. Direct microtubule binding assays confirmed this hypothesis. The decreased microtubule binding was partially prevented by 4-methyl pyrazole, indicating the effect was in part mediated by acetaldehyde. Interestingly, HDAC6 from ethanol-treated cells was able to bind and deacetylate exogenous tubulin to the same extent as control, suggesting that ethanol-induced tubulin modifications prevented HDAC6 binding to endogenous microtubules. Conclusion: We propose that lower HDAC6 levels combined with decreased microtubule binding lead to increased tubulin acetylation in ethanol-treated cells. (Hepatology 2008.)
Adenocarcinoma Arising in Meckel’s Diverticulum on 18F-FDG PET/CT
Authors: Eun Ji Han, Ie Ryung Yoo, Woo Hee Choi, Kyo-Young Lee
Journal: Clinical Nuclear Medicine (2012)

A 19-year-old girl presented with lower abdominal pain. Pelvic ultrasound showed a large cystic mass in the pelvic cavity, and CA19-9 was markedly elevated. On further evaluation, 18F-FDG PET/CT showed heterogeneous, localized FDG uptake with a central photon defect in the pelvic cavity, and most intense FDG uptake was noted in the anterior portion of lesion adjacent to the ileum. Corresponding enhanced CT showed a cystic mass abutting the ileum with wall thickening. Laparoscopic resection was done and the histologic result was adenocarcinoma arising in Meckel’s diverticulum.
High levels of expression of the transcription factor Brachyury induce resistance of human carcinoma cells to immune-mediated attack
Authors: Duane H Hamilton, Bruce Huang, Romaine I Fernando, Kwong-Yok Tsang, Claudia Palena
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts The phenomenon of epithelial-mesenchymal transition (EMT) is a phenotypic switch that allows epithelial tumor cells to acquire features of mesenchymal cells, including the ability to migrate and invade and, therefore, to disseminate from the primary site. In addition to promoting
Sexually Transmitted Diseases in Homosexual Men: Diagnosis, Treatment, and Research
Authors: Jerry D. Smilack
Journal: JAMA (1984)

If you are in the front lines of clinical medicine, you need this book. Here you can find concise, practical discussions of problems only recently receiving serious scientific study. Because the medical problems of the male homosexual have been largely neglected, physicians until recently have not been aware, for example, of Chlamydia as a cause of proctitis or amebiasis as a sexually transmitted disease. Spurred on by public awareness of homosexuality, we now are gaining increased understanding of the medical problems of the gay community.  This book is heavily laced with important tips: how to elicit a sexual history (how to speak the language) and ways to set up basic laboratory facilities in the physician's office. The major infections seen in homosexual men are given competent discussion, again with emphasis on the practical. Even noninfectious conditions afflicting gays—anal fissures and rectal trauma—receive dispassionate treatment. A short section on the acquired
People with rare diseases need better care, says chief medical officer
Authors: J. Wise
Journal: BMJ (2010)

The chief medical officer for England has called for a national clinical director for rare diseases to be appointed and for the network of reference centres for rare diseases to be strengthened.

A disease is considered rare when it affects fewer than five in every 10 000 people. There are more than 6000 rare diseases, and around three million people in England are affected by them, his annual report for 2009 says.

Speaking at the report’s launch, Liam Donaldson said, “Services for those with rare diseases are fragmented and often poorly coordinated. While there have been significant improvements in diagnosing and treating children with rare diseases, the same is not true for adults. A particular problem is the transition from children’s care to adult services, which is often difficult.”

Professor Donaldson …
Anabolic Therapies for Osteoporosis
Authors: Azeez Farooki, Monica Fornier, Monica Girotra
Journal: New England Journal of Medicine (2007)

To the Editor: In their review of anabolic therapies for osteoporosis, Canalis et al. (Aug. 30 issue)1 mention contraindications to teriparatide use, including skeletal malignant conditions. We wish to add an additional caution concerning the use of this drug in patients with a history of cancer. Patients with non–small-cell lung cancer, breast cancer, and other cancers have been shown to have micrometastatic tumor cells in the bone marrow that are associated with poor outcomes.2,3 It is not known whether patients without evidence of disease for many years have “micrometastases” in the bone marrow as well. The high-bone-turnover state (sequential . . .
The Electrocardiogram During Exercise
Authors: HENRY BLACKBURN, HENRY L. TAYLOR, C. LUIS VASQUEZ, THOMAS C. PUCHNER
Journal: Circulation (1966)

ELECTROCARDIOGRAPHIC (ECG) re- cording during exercise, employed for years by work physiologists, has only recently arrived on the scene of cardiovascular inves- tigations in clinical, epidemiological, and sports medical areas.This has come about from interest in the import of ECG events ob- served during activity, from the improved safety provided by monitoring performance tests, and from technical innovations which have led to more convenience and better qual- ity in recordings.The extension of investigations in this area and certain reasons of expediency have led to use of many nonstandard testing and monitoring procedures.These include non- standard configurations of ECG electrodes across the chest, the upright posture, FM radio transmission of the ECG, numerous other developments in instrumentation, and different modes of imposing work stress.Standardization of method in exercise elec- trocardiography is not yet possible or desir- able, because of rapid developments in quantitative cardiography and work physiol- ogy.1 Though it is not clear whether most of the nonstandard methods now used are de- sirable for the long run, they are nevertheless in use, and some quantitative base for the diagnostic and prognostic information sought from these methods is of interest.This report concerns a specific application in which nonstandard electrocardiography
Postradiotherapy Pelvic Fractures
Authors: William Small, Lisa Kachnic
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation
Authors: Sung W. Choi, Gerhard C. Hildebrandt, Krystyna M. Olkiewicz, David A. Hanauer, Meghana N. Chaudhary, Ines A. Silva, Clare E. Rogers, Daphne T. Deurloo, Jacki M. Fisher, Chen Liu, David Adams, Stephen W. Chensue, Kenneth R. Cooke
Journal: Blood (2007)
Chest Pain with a Surprising Course
Authors: Lisa R. Thomas, Lindsey Baden, Dori F. Zaleznik
Journal: New England Journal of Medicine (1999)

This Clinical Problem-Solving case is based on a presentation at the Beth Israel Deaconess Medical Center Morbidity and Mortality Conference. A 73-year-old man with insulin-dependent diabetes mellitus and a history of coronary artery disease came to the emergency department because of chest pain of one hour's duration that radiated to the jaw and back, shortness of breath, diaphoresis, and a nonproductive cough. The pain was similar to the angina he usually experienced, except for an intermittent pleuritic component with accompanying discomfort on the right side of the chest. An electrocardiogram showed right bundle-branch block with T-wave inversion in leads . . .
EXPERIMENTAL HYPERSENSITIVITY IN THE RABBIT
Authors: Louis Schwab, Frederick C. Moll, Thomas Hall, Henry Brean, Marjorie Kirk, Clinton Van Zandt Hawn, Charles A. Janeway
Journal: The Journal of Experimental Medicine (1950)

X-radiation and nitrogen mustard administration inhibit the formation of precipitins for whole bovine serum and bovine serum gamma globulin in the rabbit. When specific antibody formation is inhibited by these agents, intravenous injection of a single large dose of bovine serum gamma globulin is not usually followed by the development of tissue lesions 9 to 11 days later, as occurs fairly regularly in control animals. A fall in titre of serum complement to very low levels for 3 to 5 days is closely correlated in time with the disappearance of antigen from the circulation following the intravenous injection of single large doses of bovine serum albumin and bovine serum gamma globulin. A rise in complement titre to normal levels occurs as antibodies appear in the serum. This sudden fall in complement titre is correlated with the development of characteristic lesions, and does not occur when antibody formation is inhibited. The data presented are interpreted as evidence in favor of the concept that the lesions are due to a reaction between antigen fixed in or on tissue cells and circulating antibody. The possible significance of serum complement in the pathogenesis of anaphylactic tissue lesions is discussed.
PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin
Authors: Gemma M. Ryan, Lisa M. Kaminskas, Jürgen B. Bulitta, Michelle P. McIntosh, David J. Owen, Christopher J.H. Porter
Journal: Journal of Controlled Release (2013)
Self-Monitoring of Blood Glucose in Patients With Type 2 Diabetes Who Are Not Using Insulin
Authors: Mayer B. Davidson
Journal: Diabetes Care (2005)

Response to Welschen et al. and Kleefstra et al.

I should take responsibility for the differences between the Cochrane Library analysis and the review that appeared in Diabetes Care (1). In the Cochrane Library analysis, no meta-analysis was done for the reasons given in the letter written by Kleefstra et al. (2). However, in the initial submission to this journal, which utilized the same approach as in the Cochrane Library analysis, the authors concluded that the “level of available evidence for the effect of SMBG …
Improved intracellular delivery of peptide- and lipid-nanoplexes by natural glycosides
Authors: Alexander Weng, Maria D.I. Manunta, Mayank Thakur, Roger Gilabert-Oriol, Aristides D. Tagalakis, Ayad Eddaoudi, Mustafa M. Munye, Conrad A. Vink, Burkhard Wiesner, Jenny Eichhorst, Matthias F. Melzig, Stephen L. Hart
Journal: Journal of Controlled Release (2015)
Cisplatin-associated anemia: an erythropoietin deficiency syndrome.
Authors: P A Wood, W J Hrushesky
Journal: Journal of Clinical Investigation (1995)

Cisplatin-based therapy results in a cumulative anemia that is disproportionate to the effects on other blood cells. The severity of this treatment-induced anemia and the resultant transfusion requirement in cancer patients correlate with cisplatin-induced renal tubular dysfunction. Observed/expected serum erythropoietin (EPO) ratios decline with progressive cisplatin therapy and are proportionate to the degree of renal dysfunction. Recovery from anemia and of observed/expected serum EPO ratios in patients occurs after cessation of cisplatin therapy, along with restoration of renal tubular function. Creatinine clearance, however, remains permanently depressed. Cisplatin-treated rats develop progressive renal dysfunction and anemia that persists for many weeks, without effects on white blood cell counts. The anemia is also associated with a lack of expected EPO and reticulocyte response. With EPO administration, cisplatin-treated rats exhibit a greater reticulocyte response and hematocrit increment then non-cisplatin-treated rats given EPO, indicating minimal erythroid precursor cell damage from cisplatin. These results indicate the primary etiology of cisplatin-associated anemia is a transient, but persisting EPO deficiency state resulting from cisplatin-induced renal tubular damage, which can be prevented or treated by hormone (EPO) replacement.
Patient Interest in Sharing Personal Health Record Information
Authors: Donna M. Zulman, Kim M. Nazi, Carolyn L. Turvey, Todd H. Wagner, Susan S. Woods, Larry C. An
Journal: Annals of Internal Medicine (2011)

Background: Electronic personal health record (PHR) systems are proliferating but largely have not realized their potential for enhancing communication among patients and their network of care providers. Objective: To explore preferences about sharing electronic health information among users of the U.S. Department of Veterans Affairs (VA) PHR system, My HealtheVet. Design: Web-based survey of a convenience sample. Setting: My HealtheVet Web site from 7 July through 4 October 2010. Participants: 18 471 users of My HealtheVet. Measurements: Interest in shared PHR access and preferences about who would receive access, the information that would be shared, and the activities that users would delegate. Results: Survey respondents were predominantly men (92%) and aged 50 to 64 years (51%) or 65 years or older (39%); approximately 39% reported poor or fair health status. Almost 4 of 5 respondents (79%) were interested in sharing access to their PHR with someone outside of their health system (62% with a spouse or partner, 23% with a child, 15% with another family member, and 25% with a non-VA health care provider). Among those who selected a family member other than a spouse or partner, 47% lived apart from the specified person. Preferences about degree of access varied on the basis of the type of information being shared, the type of activity being performed, and the respondent's relationship with the selected person. Limitations: The survey completion rate was 40.8%. Results might not be generalizable to all My HealtheVet users. Conclusion: In a large survey of PHR users in the VA system, most respondents were interested in sharing access to their electronic health information with caregivers and non-VA providers. Existing and evolving PHR systems should explore secure mechanisms for shared PHR access to improve information exchange among patients and the multiple persons involved in their health care. Primary Funding Source: Veterans Health Administration and The Robert Wood Johnson Foundation Clinical Scholars Program.
CIRCULATING CONCENTRATIONS OF SOLUBLE ST2 IDENTIFY BENEFIT OF HIGH DOSE BETA BLOCKER IN CHRONIC HEART FAILURE: RESULTS FROM THE PROBNP OUTPATIENT TAILORED CHRONIC HEART FAILURE THERAPY (PROTECT) STUDY
Authors: Hanna Kim Gaggin, Shweta Motiwala, Anju Bhardwaj, Jackie Szymonifka, Kimberly Parks, James Januzzi
Journal: Journal of the American College of Cardiology (2013)
Neurologic Relapse after Benzathine Penicillin Therapy for Secondary Syphilis in a Patient with HIV Infection
Authors: Carol Dawn Berry, Thomas M. Hooton, Ann C. Collier, Sheila A. Lukehart
Journal: New England Journal of Medicine (1987)

TREPONEMA pallidum, the etiologic agent of syphilis, may be detected in the cerebrospinal fluid during early infection. The recommended therapeutic agent for primary, secondary, and latent syphilis, benzathine penicillin, does not reach treponemicidal levels within the cerebrospinal fluid, and concerns have been raised that current treatment regimens may be inadequate, particularly in patients who harbor spirochetes in their central nervous systems.We report the failure of benzathine penicillin in the treatment of secondary syphilis in a homosexual man who was seropositive for human immunodeficiency virus (HIV). After therapy, his serum Venereal Disease Research Laboratory (VDRL) test titers decreased appropriately . . .
Physician Disclosure of Financial Incentives
Authors: Jon Yardney
Journal: Annals of Internal Medicine (1993)

Letters1 July 1993Physician Disclosure of Financial IncentivesJon Yardney, MDJon Yardney, MD407 East Lancaster Avenue; St. Davids, PA 19087-4202Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-1-199307010-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Given the rapid growth of for-profit health maintenance organizations (HMOs) that use physicians in private practice as gatekeepers, I was surprised that the Ethics Committee omitted any specific discussion of ethical issues involving managed care in the third edition of the American College of Physicians Ethics Manual [1]. I offer the following for the Committee's consideration.Because it is unethical for physicians to receive kickbacks for referring patients to specialists, it must be equally unethical for physician-gatekeepers to accept hidden payments (in the form of risk-sharing bonuses) from an HMO for not referring a patient to a ...REFERENCE1. American College of Physicians Ethics Committee. American College of Physicians Ethics Manual. Third edition. Ann Intern Med. 1992; 117:947-60. Google Scholar Author, Article, and Disclosure InformationAuthors: Jon Yardney, MDAffiliations: 407 East Lancaster Avenue; St. Davids, PA 19087-4202 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1993Volume 119, Issue 1Page: 95KeywordsConflicts of interestDisclosureHealth maintenance organizationsMotivationSub-specialty care ePublished: 15 August 2000 Issue Published: 1 July 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Infections in Nursing Homes and Long Term Care Facilities
Authors: Anand P. Panwalker
Journal: JAMA (1992)

Nursing homes in the United States provide shelter and comfort to approximately 1.5 million chronically ill or elderly Americans. These are unique institutions since they are really neither "home" nor "hospital," and they vary greatly in the quality of care and caring. Even though the nosocomial infection rates are known to be high, and infections frequently prompt the transfer of patients to hospitals, infection control practices in many of these institutions leave much to be desired. The authors state that "the nursing home is an exciting and fulfilling place to teach, carry out research and practice medicine" and offer this book as a "useful reference source for physicians, nurses, administrators and all those involved with the nursing home." I believe they have succeeded in their objectives. The multiauthored text has 16 chapters, 13 figures, and 41 tables. Eight chapters are devoted to infections of various organ systems, which include pneumonias,