tbuckley/cabot-search huggingface dataset:
Dr Péan Operating
Authors: M. Therese Southgate
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival
Authors: Anne J. Novak, Jaime R. Darce, Bonnie K. Arendt, Brandon Harder, Kathy Henderson, Wayne Kindsvogel, Jane A. Gross, Philip R. Greipp, Diane F. Jelinek
Journal: Blood (2003)
The Use of Electricity in Ear-Disease
Authors: E. Woakes
Journal: BMJ (1881)

<b>Background:</b> Eotaxin is a chemokine specific for eosinophils and may play an important role in eosinophil recruitment in asthma. The effects of eotaxin inhalation on sputum and blood eosinophils, exhaled nitric oxide (NO), and bronchial responsiveness were determined. <b>Methods:</b> Eotaxin was administered by nebulisation to asthma patients in three studies: (1) an open dose finding study with eotaxin (5, 10 and 20 μg) to two asthmatic subjects; (2) a randomised placebo controlled study with 20 μg eotaxin to five asthmatic subjects and five normal volunteers; and (3) a randomised placebo controlled study with 40 μg eotaxin to nine asthmatics. Forced expiratory volume in 1 second (FEV<sub>1</sub>), exhaled NO, and blood eosinophils were measured before and hourly for 5 hours after nebulisation and at 24 and 72 hours. Methacholine bronchial challenge and sputum induction were performed before and at 5, 24, and 72 hours after nebulisation. <b>Results:</b> In the two placebo controlled studies there was no change in sputum eosinophil count and sputum eosinophilic cationic protein concentration after eotaxin inhalation compared with placebo. FEV<sub>1</sub>, exhaled NO, and methacholine PC<sub>20</sub> did not change. However, high dose eotaxin (40 μg) induced an increase in sputum neutrophil count compared with placebo (p&lt;0.05). <b>Conclusions:</b> Inhaled eotaxin up to 40 μg induced no changes in sputum eosinophil count but at 40 μg it increased the sputum neutrophil count. The significance of this finding is unknown.
Family accuses doctors of failing to warn of risk
Authors: C. Dyer
Journal: BMJ (1997)

The parents of a boy left severely brain damaged after a heart transplant operation accused doctors in the High Court in London last week of failing to warn them of the risk.

Kevin and Linda Poynter sued Hillingdon Health Authority in west London for damages on behalf of their son, Matthew, now aged 10. They claim that they would never have consented to the operation in 1987, when their son was aged 16 months, if the surgeon, Sir Magdi Yacoub, and his team at Harefield Hospital had told them that there …
Does dietary intake of vitamins C and E influence lung function in older people?
Authors: L Dow, M Tracey, A Villar, D Coggon, B M Margetts, M J Campbell, S T Holgate
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Antioxidants in the lung have a protective role against oxidative damage. We have investigated whether dietary antioxidant intake in elderly people is related to lung function. Dietary intakes of ascorbic acid (vitamin C) and alpha-tocopherol (vitamin E) and lung function were assessed in 178 men and women aged 70 to 96 yr selected on the basis of reported respiratory symptoms. After adjustment for age, gender, height, smoking habits, total energy intake, and vitamin C intake by multiple linear regression, vitamin E intake was significantly associated with FEV1 p = 0.012 and FVC p = 0.003. There was no evidence of any interaction between vitamin E intake and current tobacco smoking as determinants of lung function. For every extra milligram increase in vitamin E in the daily diet, FEV1 increased by an estimated 42 ml and FVC by an estimated 54 ml. These results suggest that dietary intake of vitamin E may influence lung function in the elderly, but food frequency questionnaires in this study were not of sufficient sensitivity to explore this hypothesis further.
A new recombinant mosquito salivary allergen, rAed a 2: allergenicity, clinical relevance, and cross‐reactivity
Authors: Z. Peng, W. Xu, H. Lam, L. Cheng, A. A. James, F. E. R. Simons
Journal: Allergy (2006)

Background: Mosquito salivary proteins cause allergic reactions in humans. The allergenicity, clinical relevance, and species cross‐reactivity of a new 37‐kDa recombinant mosquito ( Aedes aegypti ) salivary allergen, rAed a 2, were evaluated. Methods: rAed a 2 was expressed using a baculovirus/insect cell system and purified. Its allergenicity was examined using an enzyme‐linked immunosorbent assay (ELISA), ELISA inhibition tests, immunoblots, and skin tests. Epicutaneous tests with the allergen, mosquito whole body extracts, and mosquito bite tests were performed on 48 volunteers. Serum rAed a 2‐specific immunoglobulin E (IgE) was measured in individuals with positive mosquito saliva‐specific IgE and negative controls. Results: Both immunoblots and ELISAs demonstrated that rAed a 2 bound to the IgE of mosquito‐allergic individuals. The binding could be inhibited by the addition of a natural mosquito preparation. Furthermore, rAed a 2 induced immediate and delayed skin reactions. Ten per cent of 31 participants with a positive mosquito bite test had positive skin reactions to rAed a 2, compared with 32% for mosquito whole body extract. None of the participants with a negative bite test showed positive reactions to either of the two extracts. Forty‐three per cent of individuals with positive saliva‐IgE had positive rAed a 2‐IgE. rAed a 2 was a species‐shared allergen, being present in the saliva of the 11 species studied. Conclusions: rAed a 2 has identical antigenicity and biologic activity to its native form. It can be used in the diagnosis of mosquito allergy, and is an important species‐shared antigen.
MODERN URETHROSCOPY AND CYSTOSCOPY—CATHETERIZATION OF THE URETERS AND INTRAVESICAL REMOVAL OF TUMORS.
Authors: FERD. C. VALENTINE
Journal: JAMA (1895)

Even those who have not gone very deeply into the recent literature of genito-urinary surgery, can not fail to be impressed with the correct idea that the title of this paper encompasses more than can be said in the time allotted at any meeting. Indeed, the title suggests volumes, conjures up visions of a very large library and actually covers a vast experience on the part of those who have given special attention to this most important branch of the healing art. The greater portion of this experience can not be written, for it depends upon practice of the hand and eye. For these reasons this paper can practically be little more than a demonstration of instruments. I beg leave to divide this demonstration into four parts, omitting historical considerations entirely. <h3>1. Modern Urethroscopy.</h3> —The instruments I have the privilege of showing are: The Posner urethroscope is the simplest form
Randomised trial of compliance with screening for colorectal cancer.
Authors: S Nichols, E Koch, R C Lallemand, R J Heald, L Izzard, D Machin, M A Mullee
Journal: BMJ (1986)

A randomised trial of compliance with screening for colorectal cancer by means of the haemoccult test was conducted in Farnborough and Basingstoke districts. In each of the 14 participating practices (41 general practitioners) 25 852 men and women aged between 40 and 70 years were randomly allocated by household to one of six groups. The group determined the method of invitation to screening: a letter and the test were sent to the patient, or a letter with an appointment to attend the surgery was sent, or during a routine consultation the general practitioner invited patients to participate, and some patients received an educational booklet about bowel disorders and screening. Of the 17 824 people who were offered screening, 7545 (42%) complied. Compliance was significantly affected by the method of invitation, but not by whether an educational booklet was received, and was highest (57%) in the group that was offered the haemoccult test during a routine consultation (the "opportunistic" approach). In this group the compliance rate achieved by individual general practitioners ranged from 26% to 82%. Compliance was significantly higher in Farnborough, in the older (55-70) age group, in women, and in households in which two or more people were offered screening. The higher compliance in Farnborough may be explained by the higher proportion of older people and by the higher proportion of people living in households of two or more in the population that was offered screening. The fact that the screening programme in Farnborough was offered to the whole community and that the researcher may have acted as a facilitator were probably also important. One per cent of the patients screened had a positive test, and 24 (38%) of the 63 patients who were positive and were investigated in hospital had neoplastic disease. The yield was 1.2 cancers and 1.2 benign adenomas (1 cm or larger in size) per 1000 people screened. This low yield is likely to be a consequence of the relatively young age group screened.
Diffuse plane xanthomatosis associated with a monoclonal band displaying anti-smooth muscle antibody activity
Authors: P. C. SHARPE, J. F. DAWSON, M. J. O'KANE, M.Y. WALSH, S.A. McMILLAN, D. P. NICHOLLS
Journal: British Journal of Dermatology (1995)

Journal Article Diffuse plane xanthomatosis associated with a monoclonal band displaying anti‐smooth muscle antibody activity Get access P. C. SHARPE, P. C. SHARPE Department of Clinical Biochemistry, Royal Victoria Hospital, Grosvenor Rd, Belfast BT12 6BA U.K. Search for other works by this author on: Oxford Academic Google Scholar J. F. DAWSON, J. F. DAWSON Department of Dermatology, Ulster Hospital, Dundonald BTI6 ORH, U.K. Search for other works by this author on: Oxford Academic Google Scholar M. J. O'KANE, M. J. O'KANE Department of Clinical Biochemistry, Royal Victoria Hospital, Grosvenor Rd, Belfast BT12 6BA U.K. Search for other works by this author on: Oxford Academic Google Scholar M.Y. WALSH, M.Y. WALSH Department of Pathalogy, Royal Victoria Hospital, Grosvenor Rd, Belfast BT12 6BA, U.K. Search for other works by this author on: Oxford Academic Google Scholar S.A. McMILLAN, S.A. McMILLAN Regional Immunology Laboratory, Belfast City Hospital, Lisburn Rd. Belfast BT9 7AD, U.K. Search for other works by this author on: Oxford Academic Google Scholar D. P. NICHOLLS D. P. NICHOLLS Department of Medicine, Royal Victoria Hospital, Grosvenor Rd, Belfast BT12 6BA U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 133, Issue 6, 1 December 1995, Pages 961–966, https://doi.org/10.1111/j.1365-2133.1995.tb06934.x Published: 01 December 1995 Article history Accepted: 25 August 1994 Published: 01 December 1995
Effect of enkephalin and naloxone on gastric acid and serum gastrin and pancreatic polypeptide concentrations in humans.
Authors: S J Konturek, N Kwiecien, W Obtulowicz, J Swierczek, W Bielanski, J Oleksy, D H Coy
Journal: Gut (1983)

The effects of a synthetic enkephalin analogue with prolonged opioid activity, D-ala-2-enkephalin (ala-enk) and naloxone given alone or in combination, on vagally, pentagastrin- and histamine-induced gastric secretion and plasma hormonal responses to vagal stimulation have been studied in healthy subjects. D-ala-2-enkephalin reduced basal gastric acid and pepsin secretion, and caused a dose-dependent inhibition of gastric secretory responses to modified sham-feeding and pentagastrin but not to histamine. It increased serum gastrin concentration and suppressed plasma pancreatic polypeptide response to modified sham-feeding. Naloxone alone at lower dose levels did not affect gastric secretion and plasma hormonal concentrations but at higher doses it reduced both basal and modified sham-feeding-induced secretion. When combined with ala-enk it reversed in part gastric secretory and plasma hormonal changes induced by this peptide during modified sham-feeding and pentagastrin stimulation. These results indicate that (1) stable enkaphalin analogue inhibits basal and vagally or pentagastrin-induced gastric secretion, and affects plasma hormonal response to vagal stimulation, at least in part, via activation of opioid receptors and (2) endogenous opioid substances may be involved in the stimulation of gastric secretion in man.
To Confront Ethical Issues in Medicine
Authors: Daniel Callahan
Journal: New England Journal of Medicine (1975)

When I was a graduate student in philosophy, at Harvard in the late 1950's, medical ethics was a subject of no interest whatever. Our regular fare was Russell and Frege on the logical foundations of mathematics, or Wittgenstein on the uses of language. Normative ethical questions, whether about medicine, war and peace, or welfare policy, were considered out of bounds for the prevailing analytic philosophy. Nor was the medical profession clamoring for the participation of philosophers and others in grappling with medical ethics.When some newly found colleagues and I conceived the idea of the Institute of Society, Ethics and . . .
Functional Dyspepsia — Managing the Conundrum
Authors: George F. Longstreth
Journal: New England Journal of Medicine (2006)

Every day, in countless examination rooms around the world, patients are consulting their doctors about chronic stomach pain. In industrialized countries, medical evaluation usually uncovers no structural cause for chronic upper abdominal pain or discomfort; the majority of patients have functional, or nonulcer, dyspepsia. Although some general principles are useful in managing functional dyspepsia, the therapies that have been assessed to date provide little hope of a cure for this perplexing disorder.Most patients with dyspepsia are first evaluated by primary care practitioners, who should elicit a detailed history to identify patients whose symptoms may be attributable to medication use, . . .
A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation
Authors: Silvia Bozza, Katia Perruccio, Claudia Montagnoli, Roberta Gaziano, Silvia Bellocchio, Emanuela Burchielli, Gabriel Nkwanyuo, Lucia Pitzurra, Andrea Velardi, Luigina Romani
Journal: Blood (2003)
SUPPRESSION OF BILE AS A RESULT OF IMPAIRMENT OF LIVER FUNCTION
Authors: D. R. Drury, Peyton Rous
Journal: The Journal of Experimental Medicine (1925)

Prolonged chloroform anesthesia causes an acute suppression of bile, as evidenced by the secretion of a thin "white bile" from which bilirubin, cholesterol, and bile salts are absent. The failure of the liver to secrete bilirubin under such circumstances is not due to failure of the pigment to be formed within the body. Indeed an unusual amount is elaborated after chloroform anesthesia because of a blood destruction. The evidence all goes to show that the bile suppression is consequent upon a functional disturbance of the liver, not upon obstruction to outflow. Even uncomplicated biliary obstruction, as when the common duct is tied in animals otherwise normal, results in a disturbance of the liver cells such that their secretory function is impaired, as shown by the inability to take up and secrete sodium indigotate. The various circumstances under which white bile may be formed are considered and the clinical implications of the phenomenon are discussed.
THE DEVELOPMENT OF CARDIAC MURMURS DURING ATTACKS OF BILIARY COLIC.
Authors: DAVID RIESMAN
Journal: JAMA (1907)

In two cases I have had the opportunity of observing, a systolic murmur, not previously present, was heard during or soon after an attack of biliary colic. The first case was in a woman, a doctor's mother, sixty-one years of age, who had had her first attack of gallstone colic eighteen years before. I saw her in a typical seizure, the third within a few days, as a sequel to which she passed five faceted stones. At the first examination I discovered a loud, systolic murmur at the apex, which the doctor assured me had not been present before. There was no accentuation of the second pulmonic sound. The murmur persisted for nine days; the jaundice, which was pronounced, lasted only four days. After an interval of two years, during which the patient was very well, she had another attack of biliary colic with jaundice, but without murmur, and without
Papular polymorphic light eruption: an immunoperoxidase study using monoclonal antibodies
Authors: J. E. MUHLBAUER, A. K. BHAN, T. J. HARRIST, J. D. BERNHARD, M. C. MIHM
Journal: British Journal of Dermatology (1983)

Journal Article Papular polymorphic light eruption: an immunoperoxidase study using monoclonal antibodies Get access J. E. MUHLBAUER, J. E. MUHLBAUER The Departments of Pathology and Dermatology, and the Dermatopathology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, U.S.A. Jan E. Muhlbauer, M. D., Dermatopathology Unit, Warren 5, Massachusetts General Hospital, Boston, MA 02114, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar A. K. BHAN, A. K. BHAN The Departments of Pathology and Dermatology, and the Dermatopathology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar T. J. HARRIST, T. J. HARRIST The Departments of Pathology and Dermatology, and the Dermatopathology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar J. D. BERNHARD, J. D. BERNHARD The Departments of Pathology and Dermatology, and the Dermatopathology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar M. C. MIHM, JR M. C. MIHM, JR The Departments of Pathology and Dermatology, and the Dermatopathology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 108, Issue 2, 1 February 1983, Pages 153–162, https://doi.org/10.1111/j.1365-2133.1983.tb00057.x Published: 01 February 1983 Article history Accepted: 07 June 1982 Published: 01 February 1983
Neutrophil kinetics in man.
Authors: J T Dancey, K A Deubelbeiss, L A Harker, C A Finch
Journal: Journal of Clinical Investigation (1976)

A method has been developed for measuring neutrophil cellularity in normal human bone marrow, in which the neutrophil-erythroid ratio was determined from marrow sections and marrow normoblasts were estimated by the erythron iron turnover. Neutrophil maturational categories, defined by morphologic criteria, were supported by autoradiographs of marrow flashed-labeled with 3H-thymidine. Correction for multiple counting error was empirically derived by counting serial sections through cells of each maturational category. The normal neutrophil-erythroid ratio in 13 normal human subjects was 1.5 +/- 0.07. The mean number of normoblasts in the same subjects was estimated to be 5.07 +/- 0.84 X 10(9) cells/kg. Total marrow neutrophils (X 10(9) cells/kg) were 7.70 +/- 1.20, the postmitotic pool (metamyelocytes, bands, and segmented forms) was 5.59 +/- 0.90 and the mitotic pool (promyelocytes + myelocytes) was 2.11 +/- 0.36. Marrow neutrophil ("total") production has been determined from the number of neutrophils comprising the postmitotic marrow pool divided by their transit time Transit time was derived from the appearance in circulating neutrophils of injected 3H-thymidine. The postmitotic pool comprised 5.59 +/- 0.90 X 10(9) neutrophils/kg, and the transit time was 6.60 +/- 0.03 days. From these data marrow neutrophil production was calculated to be 0.85 X 10(9) cells/kg per day. Effective production, measured as the turnover of circulating neutrophils labeled with 3H-thymidine, was 0.87 +/- 0.13 X 10(9) cells/kg per day. This value correlated well with the calculation of marrow neutrophil production. A larger turnover of 1.62 +/- 0.46 X 10(9) cells/kg per day was obtained when diisopropylfluorophosphate-32P was used to label circulating neutrophils. Studies using isologous cells doubly labeled with 3H-thymidine and diisopropylfluorophosphate-32P demonstrated a lower recovery and shorter t1/2 of the 32P label.
386 THERAPEUTIC EFFICACY OF RADIOTHERAPY IN PATIENTS WITH INFERIOR VENA CAVA INVASION BY HEPATOCELLULAR CARCINOMA
Authors: J.E. Koo, Y.S. Lim, H.W. Park, J.H. Kim, K.M. Kim, H.C. Lee, Y.H. Chung, Y.S. Lee, D.J. Suh
Journal: Journal of Hepatology (2008)
Phase I/II Study of a 3 Weekly Oral Taxane (DJ-927) in Patients with Recurrent, Advanced Non-small Cell Lung Cancer
Authors: Paul Baas, A Szczęsna, I Albert, J Milanowski, E Juhász, Z Sztancsik, J von Pawel, R Oyama, S Burgers
Journal: Journal of Thoracic Oncology (2008)
Sentinel-Lymph-Node Biopsy for Cutaneous Melanoma
Authors: Jeffrey E. Gershenwald, Merrick I. Ross
Journal: New England Journal of Medicine (2011)

In a patient with cutaneous melanoma, a sentinel-lymph-node biopsy is performed with the aid of a handheld gamma scanner and the use of isosulfan blue dye. The nodes are dissected as a group and then separated in preparation for histologic analysis.