Factor V Leiden and Venous Thromboembolism
Authors: Philip T. Murphy
Journal: Annals of Internal Medicine (2004)

Letters21 September 2004Factor V Leiden and Venous ThromboembolismPhilip T. Murphy, MDPhilip T. Murphy, MDFrom Beaumont Hospital, Dublin 9, Ireland.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-6-200409210-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The paper by Juul and colleagues (1), which estimated the increased risks for venous thromboembolism (VTE) in the adult Danish population according to the factor V Leiden genotype, is clearly of great interest. What appears to be of at least equal interest are the authors' findings that risk for VTE is higher in factor V Leiden heterozygotes and homozygotes who smoke. Over the years, studies have suggested that incidence of VTE is lower in smokers than in nonsmokers (2), although results of such case–control studies may well have been biased by factors such as age and exclusion ...References1. Juul K, Tybjaerg-Hansen A, Schnohr P, Nordestgaard BG. Factor V Leiden and the risk for venous thromboembolism in the adult Danish population. Ann Intern Med. 2004;140:330-7. [PMID: 14996674] LinkGoogle Scholar2. Ridker PM, Hennekens CH, Selhub J, Miletich JP, Malinow MR, Stampfer MJ. Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism. Circulation. 1997;95:1777-82. [PMID: 9107163] CrossrefMedlineGoogle Scholar3. Hansson PO, Eriksson H, Welin L, Svardsudd K, Wilhelmsen L. Smoking and abdominal obesity: risk factors for venous thromboembolism among middle-aged men: “the study of men born in 1913”. Arch Intern Med. 1999;159:1886-90. [PMID: 10493318] CrossrefMedlineGoogle Scholar4. Nightingale AL, Lawrenson RA, Simpson EL, Williams TJ, MacRae KD, Farmer RD. The effects of age, body mass index, smoking and general health on the risk of venous thromboembolism in users of combined oral contraceptives. Eur J Contracept Reprod Health Care. 2000;5:265-74. [PMID: 11245554] CrossrefMedlineGoogle Scholar5. Bloemenkamp KW, Rosendaal FR, Helmerhorst FM, Buller HR, Vandenbroucke JP. Enhancement by factor V Leiden mutation of risk of deep-vein thrombosis associated with oral contraceptives containing a third-generation progestagen. Lancet. 1995;346:1593-6. [PMID: 7500751] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Beaumont Hospital, Dublin 9, Ireland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoFactor V Leiden and the Risk for Venous Thromboembolism in the Adult Danish Population Klaus Juul , Anne Tybjærg-Hansen , Peter Schnohr , and Børge G. Nordestgaard Factor V Leiden and Venous Thromboembolism Jan P. Vandenbroucke and Frits R. Rosendaal Factor V Leiden and Venous Thromboembolism Klaus Juul , Børge G. Nordestgaard , and Anne Tybjærg-Hansen Metrics 21 September 2004Volume 141, Issue 6Page: 483-484KeywordsAdultsCohort studiesDeep vein thrombosisEstrogensFactor V LeidenGenotypingMedical risk factorsOral contraceptive therapyRelative riskVenous thromboembolism ePublished: 21 September 2004 Issue Published: 21 September 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...