tbuckley/cabot-search huggingface dataset:
Awareness may be existence as well as (higher-order) thought
Authors: Jordan B. Peterson
Journal: Behavioral and Brain Sciences (2000)

Rolls attributes to consciousness the functions of reflection, planning, and error-correction. Neuropsychologically grounded cybernetic theory provides an analogous, broader conceptualization: consciousness constructs goals (and plans), alters the valence of goal-related phenomena, registers error-signals, and explores unexpected circumstances (reconfiguring goals and plans as necessary). Consciousness plays a fundamental unrecognized ontological role, as well, conferring the status of “discriminable object” on select aspects of otherwise indeterminate “being.”
FIBROBLAST GROWTH FACTOR 23 AND LOW 25 OH VITAMIN D PLASMA LEVELS ARE INDEPENDENT PREDICTORS OF CARDIOVASCULAR EVENTS IN PATIENTS WITH CHRONIC CORONARY ARTERY DISEASE
Authors: José Tuñón, Carmen Cristóbal, Nieves Tarin, Emilio Gonzalez-Parra, Álvaro Aceña, María Luisa Gonzalez-Casaus, Ana Isabel Huelmos, Óscar Lorenzo, Joaquín Alonso-Martín, Jesús Egido, Lorenzo López-Bescós
Journal: Journal of the American College of Cardiology (2013)
TGFbeta1 regulates gene expression of its own converting enzyme furin.
Authors: F Blanchette, R Day, W Dong, M H Laprise, C M Dubois
Journal: Journal of Clinical Investigation (1997)

TGFbeta1 is known for its potent and diverse biological effects, including immune regulation, and cell growth and differentiation. We have recently shown that TGFbeta1 precursor is processed by human furin COOH-terminal to the R-H-R-R278 cleavage site to generate authentic mature TGFbeta1. In the present study, we demonstrate that steady-state furin mRNA levels are increased in rat synovial cells by 2 and 20 ng/ml TGFbeta1. Stimulation with TGFbeta1 results in a significant increase in furin mRNA levels, starting at 3 h with the peak effect observed at 12 h (2.5-fold increase +/-0.4). TGFbeta1 did not increase furin mRNA stability, and treatment of synovial cells with actinomycin D, before TGFbeta1 addition prevented the increase in fur gene expression, suggesting that the observed regulation occurs at the level of gene transcription. Treatment of synovial and NRK-49F fibroblastic cells with exogenous TGFbeta1 (5 ng/ml) or TGFbeta2 (10 ng/ml) translates into an increase in pro-TGFbeta1 processing as evidenced by the appearance of a 40-kD immunoreactive band corresponding to the TGFbeta1 NH2-terminal pro-region. Furin processing activity stimulated by TGFbeta2 correlates with significant increase in extracellular mature and heat-activable TGFbeta1 as determined by an isoform-specific ELISA assay. Taken together, these results demonstrate for the first time that TGFbeta1 upregulates gene expression of its own converting enzyme, and that this expression is translated into augmented processing of the TGFbeta1 precursor form. Such adaptive responsiveness of the TGFbeta1 convertase may represent an important aspect of TGFbeta1 bioavailibility in TGFbeta1-related processes and pathological conditions.
An Autonomous Functioning Cystic Thyroid Adenoma An Unusual Occurrence
Authors: M R WILLIAMSON, C M BOYD, S L WILLIAMSON, J J SEIBERT
Journal: Clinical Nuclear Medicine (1986)

An asymptomatic thyroid nodule that appeared cystic on ultrasound was seen in a 14-year-old girl. Tc-99m pertechnetate thyroid imaging was expected to show a cold nodule, but surprisingly revealed a hyperfunctioning nodule. A partial thyroidectomy revealed an hemorrhagic cystic adenoma. The occurrence of a cystic nodule, which continued to show hyperfunction, is unusual.
T lymphocytes and the lack of activated macrophages in wound margin biopsies from chronic leg ulcers
Authors: K. MOORE, F. RUGE, K.G. HARDING
Journal: British Journal of Dermatology (1997)

Journal Article T lymphocytes and the lack of activated macrophages in wound margin biopsies from chronic leg ulcers Get access K. MOORE, K. MOORE Wound Healing Research Unit, Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, U.K. Search for other works by this author on: Oxford Academic Google Scholar F. RUGE, F. RUGE Wound Healing Research Unit, Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, U.K. Search for other works by this author on: Oxford Academic Google Scholar K.G. HARDING K.G. HARDING Wound Healing Research Unit, Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 137, Issue 2, 1 August 1997, Pages 188–194, https://doi.org/10.1046/j.1365-2133.1997.18041895.x Published: 01 August 1997
Regulation of insulin-like growth factor-I and its receptor in rat aorta after balloon denudation. Evidence for local bioactivity.
Authors: M J Khorsandi, J A Fagin, D Giannella-Neto, J S Forrester, B Cercek
Journal: Journal of Clinical Investigation (1992)

Local production of growth factors may play a major role in vascular repair after injury. We examined the regulation of insulin-like growth factor-I (IGF-I) and its specific membrane receptor in balloon-denuded rat aorta. Aortic IGF-I mRNA and radioimmunoassayable IGF-I content increased severalfold after balloon denudation with a peak at 7 d after injury. This coincided with a reciprocal 25% decrease in IGF-I receptor mRNA content and a 40% decrease in total 125I-IGF-I binding. Scatchard analysis indicated a single class of binding sites, with a decrease in receptor number at 7 d compared to control and no change in affinity. By in situ hybridization the predominant site of IGF-I expression in the normal and the denuded vessel wall was the medial smooth muscle cell. After denudation there was a relative decrease in IGF-I receptor mRNA in the medial cells as compared to the neointima, suggesting that the site of IGF-I action was predominantly in the medial layer. These data suggest that local expression and action of IGF-I are significant in the promotion of smooth muscle cell proliferation after arterial injury.
Differentiation of Viable and Nonviable Myocardium by the Use of Three-Dimensional Tagged MRI in 2-Day-Old Reperfused Canine Infarcts
Authors: P. Croisille, C. C. Moore, R. M. Judd, J. A. C. Lima, M. Arai, E. R. McVeigh, L. C. Becker, E. A. Zerhouni
Journal: Circulation (1999)

Background —To limit ischemic myocardial injury, it is important to differentiate viable from infarcted myocardium. Three dimensional (3D) tagged MRI has the ability to quantify myocardial 3D deformation and strain (noninvasively and precisely), and can achieve a true comparison of contraction not only from region to region, but also at different levels of function. In this study, we investigated whether regional strain mapping obtained by 3D-tagged MRI can differentiate between viable but stunned myocardium and nonviable myocardium. Methods and Results —We examined 7 dogs 2 days after a 90-minute closed-chest left anterior descending coronary artery occlusion followed by 48 hours of reperfusion. 3D-tagged MR images spanning the entire left ventricle were acquired both at rest and during dobutamine infusion (5 μg · kg −1 · min −1 IV). Regional blood flow was measured with radioactive microspheres and used to define risk regions. Infarcted regions were defined as 2,3,5 triphenyltetrazolium chloride negative regions. Strains in infarcted regions were greatly impaired compared with remote regions ( P &lt;0.001) and remained unchanged during dobutamine stress. Risk regions showed a dysfunction at rest, with improved function during dobutamine infusion. Receiver operating characteristics analysis showed that radial strain was more accurate for identifying viable regions. Conclusions —When coupled with a stress test, 3D strain mapping by the use of tagged MRI is a sensitive and noninvasive method for characterizing ischemic injury. Regional strain can be used to differentiate between viable but stunned and nonviable myocardium within the postischemic injured myocardium.
S46 A comparison of three different specimen types for the diagnosis of viral respiratory infections in adults with cystic fibrosis
Authors: W. G. Flight, K. J. Mutton, B. Isalska, R. J. Bright-Thomas, A. M. Jones
Journal: Thorax (2011)

<h3>Introduction</h3> Respiratory viruses have been associated with increased symptoms and a decline in lung function in patients with cystic fibrosis (CF). The optimal means of diagnosis of respiratory viruses in CF is unclear. We compared the suitability of sputum, nose- and throat-swabs for the diagnosis of respiratory viruses in adults with CF. <h3>Methods</h3> 100 adults with CF provided sputum, nose- and throat-swabs every 2 months between December 2010 and June 2011 within a prospective observational study. Samples were repeated if new respiratory symptoms developed between regular visits. Specimens were analysed using PCR assays for adenovirus, influenza, metapneumovirus, parainfluenza, respiratory syncytial virus and rhinovirus. Positive viral identification rates for each specimen type were compared. FEV<sub>1</sub>, inflammatory markers and symptom scores for upper respiratory tract infection (URTI) and pulmonary exacerbation (PEx) were recorded at each visit. <h3>Results</h3> 210 sets of samples were collected. A respiratory virus was identified at 52 (24.8%) visits of which rhinovirus accounted for 63%, influenza A 10.5%, metapneumovirus 9% and influenza B 7%. Among virus-positive cases, sputum was positive in 34 (65%), nose swab in 25 (48%) and throat swab in 21 (40%). A single specimen type was positive in 32 (62%) cases; two specimens in 12 (23%) and all three specimens in only 8 (15%). Sputum alone was positive in 17 (33%) cases, nose-swab alone in 8 (15%) and throat-swab alone in 7 (13%). An increasing number of positive specimens was associated with higher mean (SD) URTI scores (4.9 (5.0) vs 6.7 (6.6) vs 10.3 (5.5) for 0, 1 and =2 positive specimens respectively; p=0.046 for =2 vs 1 specimens) and higher PEx scores (2.8 (2.8) vs 3.2 (2.2) vs 5.1 (1.5); p=0.002). FEV<sub>1</sub>, CRP and WCC were similar between these groups. There were no significant differences in lung function, symptoms or inflammatory markers when viruses were detected in sputum compared with the upper airways. <h3>Conclusions</h3> Sputum is superior to nose- and throat-swabs for the diagnosis of respiratory viruses in adults with CF but all three are required for optimal identification rates. Viral positivity in =2 specimens is associated with higher upper and lower respiratory symptom scores.
Zinc supplementation and amino acid-nitrogen metabolism in patients with advanced cirrhosis
Authors: G Marchesini
Journal: Hepatology (1996)

Zinc deficiency is common in cirrhosis and has been involved in the altered nitrogen metabolism. In this study, we measured the effects of zinc supplementation on the dynamics of amino acid-derived urea synthesis in cirrhosis with mild or latent encephalopathy. The hepatic conversion of amino acids into urea was studied in eight patients with advanced cirrhosis under controlled conditions of substrate availability (continuous alanine infusion), before and after 3-month oral zinc sulfate supplementation (600 mg/d). Eight more patients, matched for hepatocellular failure and encephalopathy, served as controls. Plasma zinc levels were reduced in all patients and returned to normal after oral zinc. The alanine-stimulated urea nitrogen synthesis rate in relation to α-amino-N concentration–the functional hepatic nitrogen clearance–increased by 25% after zinc supplementation, i.e., more urea was produced at any α-amino-N concentration. Basal and alanine-induced glucagon decreased by 50%, and the ammonia response to alanine decreased by 30%. Psychometric tests improved, as did routine and dynamic liver function tests and the Child- Pugh score. Also, the plasma concentration of lipid peroxides was reduced by zinc. No significant changes were observed in the control group. Our data indicate that long-term oral zinc speeds up the kinetics of urea formation from amino acids and ammonia. Changes in the hormonal drive and/or the antioxidant activity of zinc might be involved in the general improvement in liver function, whereas the beneficial effects on encephalopathy might stem from decreased ammonia.
Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area
Authors: Ja Wook Koo, Michelle S Mazei-Robison, Quincey LaPlant, Gabor Egervari, Kevin M Braunscheidel, Danielle N Adank, Deveroux Ferguson, Jian Feng, Haosheng Sun, Kimberly N Scobie, Diane M Damez-Werno, Efrain Ribeiro, Catherine Jensen Peña, Deena Walker, Rosemary C Bagot, Michael E Cahill, Sarah Ann R Anderson, Benoit Labonté, Georgia E Hodes, Heidi Browne, Benjamin Chadwick, Alfred J Robison, Vincent F Vialou, Caroline Dias, Zachary Lorsch, Ezekiell Mouzon, Mary Kay Lobo, David M Dietz, Scott J Russo, Rachael L Neve, Yasmin L Hurd, Eric J Nestler
Journal: Nature Neuroscience (2015)
Abstract 5481: Antitumor activity of a novel JAK/Stat3 inhibitor, NSC-743380
Authors: Wei Guo, Shuhong Wu, Bingliang Fang, Li Wang, Xiaoying Liu
Journal: Cancer Research (2011)

Abstract We recently developed two compounds, NSC-741909 and NSC-743380, which were highly active against a subset of NCI-60 cancer cell lines. This study investigated the in vivo activities of NSC-743380 and NSC-741909 in human tumor xenografts in nude mice and the mechanism of NSC-743380 antitumor activity. In vitro antitumor activity was determined by sulforhodamine assay of cell viability. In vivo antitumor activity was determined in xenograft tumors established from the human renal cancer cell line A498. NSC-743380-induced apoptosis and changes in gene expression levels and signaling pathway activities were identified by Western blot analyses, flow cytometric analyses, or both. The role of Stat3 in NSC-743380-induced antitumor activity was determined by enforced expression of a constitutively active Stat3 construct in sensitive cancer cells. NSC-743380 is highly active against a subset of cancer cell lines derived from lung, colon, ovary, kidney, and breast cancers and has an antitumor spectrum similar to that of NSC-741909 in the NCI-60 cancer cell line panel. The in vivo study revealed that NSC-743380 has an improved toxicity profile and greater antitumor activity than NSC-741909. Treatment with NSC-743380 caused tumor regression at all three dose levels, and a portion of animals at all three doses were tumor free. Mechanistic studies revealed that treatment with NSC-743380 inhibited JAK/Stat3 phosphorylation and this inhibition was dependent on both dose and time. Our results demonstrate that NSC-743380 is a novel JAK/Stat3 inhibitor that has selective antitumor activity against a subset of cancer cell lines and has favorable in vivo antitumor activities. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5481. doi:10.1158/1538-7445.AM2011-5481
Abstract 4580: A novel role for Junctional Adhesion Molecule-A (JAM-A) in tumor proliferation: modulation by a humanized anti-JAM-A monoclonal antibody
Authors: Liliane Goetsch, Jean-François Haeuw, Matthieu Broussas, Thierry Wurch, Charlotte Beau-Larvor, Alain Robert, Christian Bailly, Nathalie Corvaia
Journal: Cancer Research (2011)

Abstract Biotherapeutic drugs in oncology are generating a great enthusiasm, and tremendous amount of effort is made to identify new targets for the development of new therapeutics. Functional approaches using tumor cells as immunogens have been performed in order to select on the basis of their function, molecules that, targeted by monoclonal antibodies (Mabs), would induce inhibition of cell proliferation both in vitro and in vivo. Using this type of approaches coupled to a target identification plateform, we had identified an antibody, named 6F4 that was inhibiting in vitro and in vivo tumor growth. A proteomic analysis using 6F4-tagged beads coupled to a MS analysis indicated that 6F4 Mab specifically recognized the human junctional adhesion molecule A (JAM-A). These results indicate that the 6F4 anti-JAM-A Mab is able to induce tumor growth inhibition. Mouse 6F4 Mab was humanized by conventional CDR-grafting methods. Immunogenetic analysis was performed based on IMGT databases and bioinformatic tools. The human frameworks (FRs) used as the acceptors for CDR grafting were chosen using the “best-fit” selection procedure. Engineered variants were designed and genes were chemically synthetized, produced as human IgG4/kappa antibodies and evaluated by ELISA and competition with biotinylated mouse 6F4 Mab. One humanized antibody (IgG4 isotype) was selected, it efficiently and potently bound to JAM-A ECD and inhibited binding of mouse 6F4. Its germinality index is &amp;gt; 95 % (CDRs excluded). Humanized 6F4 was further tested in vitro and in vivo models and showed ability to induce tumor regression in animal models in particular in A431 and DU145 tumor models. These results confirm that JAM-A is a potential novel target in Oncology and demonstrate that a functional approach coupled to proteomic analysis can be successfull to identify new antibody target molecules that lead to promising new antibody-based therapies against cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4580. doi:10.1158/1538-7445.AM2011-4580
TCT-472 Prognosis of Patients Presenting with Non ST-Segment Elevation Myocardial Infarction and Non-obstructive Coronary Artery Disease: Propensity Score Matched Cohort from the ACUITY Trial
Authors: David Planer, E. Magnus Ohman, Harvey White, Jeffrey Moses, Martin Fahy, Roxana Mehran, Gregg Stone
Journal: Journal of the American College of Cardiology (2012)
Abstract 13: Color-coded imaging of vessel anastomosis <i>in vivo</i> using RFP and CFP transgenic mice
Authors: Fuminari Uehara, Yasunori Tome, Hiroki Maehara, Kazuhiro Tanaka, Fuminori Kanaya, Shinji Miwa, Yukihiko Hiroshima, Shuya Yano, Mako Yamamoto, Yasunori Matsumoto, Robert M. Hoffman
Journal: Cancer Research (2014)

Abstract We previously report the development of a color-coded imaging model that can visualize the anastomosis between blood vessels of red fluorescent protein (RFP)-expressing vessels in Gelfoam® previously vascularized in RFP transgenic mice and blood vessels of nestin-driven green fluorescent protein (ND-GFP) mice that express GFP in nascent vessels (Anticancer Res. 33: 3041-3046, 2013). In the present study, fourteen days after transplantation into RFP transgenic nude mice, the Gelfoam® was removed and re-transplanted into the subcutis on the flank of cyan fluorescent protein (CFP) transgenic mice. Skin flaps were made and anastomosis between the CFP-expressing vessels and RFP blood vessels in the Gelfoam® was imaged 14 and 21 days after re-transplantation. The results presented in this and our previous report suggest a new paradigm of visualizing blood vessel anastomosis and its implications for tumor angiogenesis. Citation Format: Fuminari Uehara, Yasunori Tome, Hiroki Maehara, Kazuhiro Tanaka, Fuminori Kanaya, Shinji Miwa, Yukihiko Hiroshima, Shuya Yano, Mako Yamamoto, Yasunori Matsumoto, Robert M. Hoffman. Color-coded imaging of vessel anastomosis in vivo using RFP and CFP transgenic mice. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 13. doi:10.1158/1538-7445.AM2014-13
Historical benchmarks for medical therapy trials in surgery- and radiation-refractory meningioma: a RANO review
Authors: T. Kaley, I. Barani, M. Chamberlain, M. McDermott, K. Panageas, J. Raizer, L. Rogers, D. Schiff, M. Vogelbaum, D. Weber, P. Wen
Journal: Neuro-Oncology (2014)

The outcomes of patients with surgery- and radiation-refractory meningiomas treated with medical therapies are poorly defined. Published reports are limited by small patient numbers, selection bias, inclusion of mixed histologic grades and stages of illness, and World Health Organization (WHO) criteria changes. This analysis seeks to define outcome benchmarks for future clinical trial design. A PubMed literature search was performed for all English language publications on medical therapy for meningioma. Reports were tabulated and analyzed for number of patients, histologic grade, prior therapy, overall survival, progression-free survival (PFS), and radiographic response. Forty-seven publications were identified and divided by histology and prior therapies, including only those that treated patients who were surgery and radiation refractory for further analysis. This included a variety of agents (hydroxyurea, temozolomide, irinotecan, interferon-α, mifepristone, octreotide analogues, megestrol acetate, bevacizumab, imatinib, erlotinib, and gefitinib) from retrospective, pilot, and phase II studies, exploratory arms of other studies, and a single phase III study. The only outcome extractable from all studies was the PFS 6-month rate, and a weighted average was calculated separately for WHO grade I meningioma and combined WHO grade II/III meningioma. For WHO I meningioma, the weighted average PFS-6 was 29% (95% confidence interval [CI]: 20.3%–37.7%). For WHO II/III meningioma, the weighted average PFS-6 was 26% (95% CI: 19.3%–32.7%). This comprehensive review confirms the poor outcomes of medical therapy for surgery- and radiation-refractory meningioma. We recommend the above PFS-6 benchmarks for future trial design.
Response to Chauhan et al.: Interstitial Pressure and Vascular Collapse in Pancreas Cancer—Fluids and Solids, Measurement and Meaning
Authors: Kathleen E. DelGiorno, Markus A. Carlson, Ryan Osgood, Paolo P. Provenzano, J. Scott Brockenbough, Curtis B. Thompson, H. Michael Shepard, Gregory I. Frost, John D. Potter, Sunil R. Hingorani
Journal: Cancer Cell (2014)
GENERALIZED SCLERO-ATROPHY OF THE SKIN WITH FATAL MALABSORPTION—A NEW ENTITY
Authors: F. P. SCOTT, G. H. FINDLAY
Journal: British Journal of Dermatology (1971)

Journal Article GENERALIZED SCLERO‐ATROPHY OF THE SKIN WITH FATAL MALABSORPTION—A NEW ENTITY Get access F. P. SCOTT, F. P. SCOTT Department of Dermatology, University of Pretoria, South, Africa Search for other works by this author on: Oxford Academic Google Scholar G. H. FINDLAY G. H. FINDLAY Department of Dermatology, University of Pretoria, South, Africa Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 85, Issue s7, 1 December 1971, Pages 12–17, https://doi.org/10.1111/j.1365-2133.1971.tb14103.x Published: 01 December 1971