Ranitidine or Cimetidine
Authors: DENIS M. MCCARTHY
Journal: Annals of Internal Medicine (1983)

Editorials1 October 1983Ranitidine or CimetidineDENIS M. MCCARTHY, M.D., M. SC.DENIS M. MCCARTHY, M.D., M. SC.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-4-551 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPhysicians in the United States are now getting their first experience with ranitidine HCL (Zantac; Glaxo Inc., Fort Lauderdale, Florida), a new H2-receptor blocking antihistamine that inhibits gastric acid secretion with a potency four- to eightfold that of cimetidine (1, 2). In June, the FDA approved marketing of the drug for short-term oral use in the treatment of duodenal ulcer and for unrestricted use in hypersecretory states, such as the Zollinger-Ellison syndrome. The drug is not yet approved for gastric ulcer, maintenance therapy in duodenal ulcers, or parenteral use. Ranitidine received a therapeutic rating of 1C, which the FDA assigns...References1. Ranitidine (Zantac). Med Lett Drugs Ther. 1982;24:111-3. MedlineGoogle Scholar2. MISIEWICZSEWING JK. Proceedings of the First International Symposium on Ranitidine. Scand J Gastroenterol [Suppl]. 1981;16(suppl 69):1-132. Google Scholar3. LEBERTMACLEODMAHONSOLDINVANDENBERGHE PSWSH. Ranitidine kinetics and dynamics: 1. Oral dose studies. Clin Pharmacol Ther. 1981;30:539-44. CrossrefMedlineGoogle Scholar4. BARRPARISMIDDLETONPIPER GCWD. The comparison of ranitidine with cimetidine in duodenal ulcer healing. In: MISIEWICZ J, WORMSLEY KG, eds. The Clinical Use of Ranitidine: Second International Symposium on Ranitidine. Oxford: Medicine Publishing Foundation. 1982:148-53. CrossrefGoogle Scholar5. LANGMANHENRYBELLBURNHAMOGILVY MDGWA. Cimetidine and ranitidine in duodenal ulcer. Br Med J. 1980;2:473-4. CrossrefGoogle Scholar6. LISHMANRECORD AC. The use of ranitidine in the management of duodenal ulcer: controlled and open comparisons with cimetidine in 59 patients. J Clin Gastroenterol. 1982;4:421-4. CrossrefMedlineGoogle Scholar7. ROWLEY-JONESFLIND DA. Continuing evaluation of the safety of cimetidine, In: BARON JH, ed. Cimetidine in the 80s. Edinburgh; Churchill Livingstone: 1981;261-9. Google Scholar8. JENSENCOLLENPANDOL RMS. Cimetidine-induced impotence and breast changes in patients with gastric hypersecretory states. N Engl J Med. 1983;308:883-7. CrossrefMedlineGoogle Scholar9. TOSICAGNOLI SM. Painful gynecomastia with ranitidine [Letter]. Lancet. 1982;2:160. CrossrefMedlineGoogle Scholar10. Zantic launch with info changes in FRG. Scrip. 1982;635:11. Google Scholar11. EDWARDSRILEY CA. Endocrine effects of ranitidine: comparison with cimetidine In: MISIEWICZ J, WORMSLEY KG, eds. Clinical Use of Ranitidine: Second International Symposium on Ranitidine. Oxford: Medicine Publishing Foundation; 1982:65-9. Google Scholar12. LOMBARDO L. Reversible amenorrhea after ranitidine treatment [Letter]. Lancet. 1982;1:224. CrossrefMedlineGoogle Scholar13. ENGLANDWEIR SD. Letter to the editor. Ir Med J. 1983;76:262. Google Scholar14. BOYD M. Toxicity mediated by reactive metabolites of furans. Adv Exp Med Biol. 1980;136B:865-79. Google Scholar15. DUNDEEMCGOWANELWOODHILDERBRAN JWRP. Plasma benzodiazepine concentrations following oral administration with and without H2-receptor blockers. Ir J Med Sci. 1982;151:413-4. Google Scholar16. LEEGANDOLFISIPESBENTLEY HAIJ. Effect of histamine H2-receptors on fentanyl metabolism. Toxicologist. 1982;2:145. Google Scholar17. SPAHNMUTSCHLERKIRCHOHNHAUSJANISCH HEWEH. Influence of ranitidine on plasma metoprolol and antenolol concentrations. Br. Med J. 1983;286:1546-7. CrossrefMedlineGoogle Scholar18. MIHALYMARINOWEBSTERJONESLOUISSMALLWOOD GALDWR. High dose of antacid (Mylanta II) reduces bioavailability of ranitidine. Br Med J. 1982;285:998-9. CrossrefMedlineGoogle Scholar19. BORIESMICHELDUCLOSBERAUDMIROUZE PHBJJ. Use of ranitidine without mental confusion, in patient with renal failure. Lancet. 1980;2:755. CrossrefMedlineGoogle Scholar20. HUGHESREEDSERJEANT JWC. Mental confusion associated with ranitidine. Med J Aust. 1983;2:12-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DENIS M. MCCARTHY, M.D., M. SC.Affiliations: Veterans Administration Medical Center Albuquerque, New Mexico PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPharmaceuticals and personal care products in the seawater around a typical subtropical tourist city of China and associated ecological riskGuidelines of Treatment for Non-bleeding Peptic Ulcer DiseaseHEPATOTOXICITY OF DRUGS USED IN THE TREATMENT OF GASTROINTESTINAL DISORDERSUpper Gastrointestinal DisordersRanitidine treatment and cortisol metabolism in manOmeprazole for prophylaxis of acid aspiration in elective surgeryPharmacoeconomic Aspects and Formulary Considerations Related to Histamine 2 -Receptor AntagonistsReversible Hematologic Suppression during Ranitidine TreatmentEffects of equimolar doses of cimetidine and ranitidine on theophylline eliminationCyclosporin A — H2 Receptor Antagonists Drug Interaction in the Sprague-Dawley RatPrescription GuidelinesWhat's New in Drugs That Affect the Gastrointestinal Tract?Lack of efficacy of cimetidine and ranitidine as inhibitors of tolbutamide metabolismClinical Characteristics of Roxatidine Acetate: A ReviewUnconventional viruses and the central nervous system.Acute stress erosions: can they be prevented?Review: clinical trials in peptic ulcer disease-problems of methodology and interpretationThrombocytopenia, Eosinophilia, and RanitidineU. GAFTER, M.D., L. KOMLOS, Ph.D., T. WEINSTEIN, M.D., D. ZEVIN, M.D., J. LEVI, M.D.Prevention of Duodenal Ulcer RecurrenceWILLIAMSON B. STRUM, M.D.Actions of cimetidine and ranitidine at some cholinergic sites: Implications in toxicology and anesthesiaProphylaxis for aspiration pneumonitisInhibition of suppressor cell function by cimetidine in a murine modelLack of effect of nizatidine on hepatic drug metabolism in man.RANITIDINE HEPATOTOXICITY IN RENAL TRANSPLANT PATIENTSide effects and complications of amiodarone therapyIsolation of human hepatic microsomes and their inhibition by cimetidine and ranitidineFamotidine, a new H2-receptor antagonist, does not affect hepatic elimination of diazepam or tubular secretion of procainamideRanitidine, Acetaminophen, and HepatotoxicityJAMES E. BREDFELDT, M.D., CHRISTIAN VON HUENE, M.D.Hepatitis Associated with RanitidineMARCOS A. SOUZA LIMA, M.D.Possible Ranitidine HepatotoxicityMARTIN BLACK, M.D., WILBERT E. SCOTT Jr., M.D., ROBERT KANTER, M.D.RANITIDINE AND LOSS OF COLOUR VISION IN A CHILDRanitidineRanitidine and CimetidineDAVID JACK, PH.D., ROBERT N. SMITH, M.D., PETER J. WISE, M.D.Ranitidine and TheophyllineELIZABETH FERNANDES, M.D., F. MICHAEL MELEWICZ, M.D.Ranitidine and Acetaminophen HepatotoxicityK.V. SPEEG JR., M.D., PH.D., D.C. CHRISTIAN, M.D., M.C. MITCHELL, M.D.Ranitidine and CimetidineMARCOS A.S. LIMA, M.D. 1 October 1983Volume 99, Issue 4Page: 551-553KeywordsAntihistaminesDrug marketingDrug therapyDrugsDuodenal ulcersFood and Drug AdministrationGastric ulcersHydrochloric acidZollinger Ellison syndrome ePublished: 1 December 2008 Issue Published: 1 October 1983 PDF downloadLoading ...