tbuckley/cabot-search huggingface dataset:
Abnormal Platelet Function in the Myeloproliferative Disorders.
Authors: Joseph M. Cardamone
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Abnormal Platelet Function in the Myeloproliferative Disorders.Joseph M. Cardamone, M.D., J. Roger Edson, M.D., James R. McArthur, M.D., Harry S. Jacob, M.D.Joseph M. Cardamone, M.D.Search for more papers by this author, J. Roger Edson, M.D.Search for more papers by this author, James R. McArthur, M.D.Search for more papers by this author, Harry S. Jacob, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-826_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA hemorrhagic diathesis frequently complicates myeloproliferative disorders, yet its pathogenesis remains enigmatic. The frequency of abnormalities in platelet morphology in these disorders suggests platelet malfunction might underlie this defective hemostasis. Platelet function tests were performed on 21 consecutive patients with various myeloproliferative disorders (polycythemia vera, myelogenous leukemia, myelofibrosis, and erythroleukemia). Tests included platelet adhesiveness (Salzmann), factor 3 release (Russel's viper venom method), agregation induced by adenosine diphosphate, collagen and catechols, and Ivy bleeding time. All 21 patients demonstrated at least one platelet dysfunction. Multiple abnormalities correlated with increasing clinical severity of the hemorrhagic diathesis. Platelet aggregation was most often abnormal:... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Joseph M. Cardamone, M.D.; J. Roger Edson, M.D.; James R. McArthur, M.D.; Harry S. Jacob, M.D.Affiliations: Minneapolis, Minn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPlatelet Function in Patients with High Platelet CountsA. D. GINSBURG, M.D., M.R.C.P.(E), F.R.C.P.(C)Thrombocytosis and Thrombocythemia 1 May 1971Volume 74, Issue 5Page: 826-826KeywordsAdenosine diphosphateHemorrhageHemostasisMyeloproliferative disordersPathogenesisPlatelet aggregationPlateletsPolycythemia veraVenoms ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...
The natural history of chronic airflow obstruction.
Authors: C Fletcher, R Peto
Journal: BMJ (1977)

A prospective epidemiological study of the early stages of the development of chronic obstructive pulmonary disease was performed on London working men. The findings showed that forced expiratory volume in one second (FEV1) falls gradually over a lifetime, but in most non-smokers and many smokers clinically significant airflow obstruction never develops. In susceptible people, however, smoking causes irreversible obstructive changes. If a susceptible smoker stops smoking he will not recover his lung function, but the average further rates of loss of FEV1 will revert to normal. Therefore, severe or fatal obstructive lung disease could be prevented by screening smokers' lung function in early middle age if those with reduced function could be induced to stop smoking. Infective processes and chronic mucus hypersecretion do not cause chronic airflow obstruction to progress more rapidly. There are thus two largely unrelated disease processes, chronic airflow obstruction and the hypersecretory disorder (including infective processes).
P2-284: First-line treatment with vinorelbine (VRL) plus gemcitabine (GEM) for elderly patients with advanced non-small-cell lung cancer (NSCLC): Molecular correlates
Authors: Inmaculada Maestu, Dolores Isla, Manuela Pedraza, Jose Munoz, Juana Oramas, Ramon Garcia-Gomez, Sonia del Barco, Blanca Cantos, Miquel Taron, Rafael Rosell
Journal: Journal of Thoracic Oncology (2007)
Evaluation of Infection in Neutropenic Patients with lndium-111-Labeled Donor Granulocytes
Authors: JANE B. ALAVI, ABASS ALAVI, MUNI STAUM
Journal: Clinical Nuclear Medicine (1980)

Donor granulocytes, obtained by filtration leukophoresis, were labeled with ln-111-oxine and injected into seven severely neutropenic patients. All patients were febrile, and presumed to have infection, although infection was eventually proved in only five. Excellent demonstration of infection was achieved in two patients, and fair localization in one. One negative scan became positive when repeated with sedimentation-derived cells from a different donor. This method may be useful in detecting infections in neutropenic patients.
A randomised controlled crossover trial of nurse practitioner versus doctor led outpatient care in a bronchiectasis clinic
Authors: L D Sharples
Journal: Thorax (2002)

With the decrease in junior doctor hours, the advent of specialist registrars, and the availability of highly trained and experienced nursing personnel, the service needs of patients with chronic respiratory diseases attending routine outpatient clinics may be better provided by appropriately trained nurse practitioners.A randomised controlled crossover trial was used to compare nurse practitioner led care with doctor led care in a bronchiectasis outpatient clinic. Eighty patients were recruited and randomised to receive 1 year of nurse led care and 1 year of doctor led care in random order. Patients were followed up for 2 years to ensure patient safety and acceptability and to assess differences in lung function. Outcome measures were forced expiratory volume in 1 second (FEV(1)), 12 minute walk test, health related quality of life, and resource use.The mean difference in FEV(1) was 0.2% predicted (95% confidence interval -1.6 to 2.0%, p=0.83). There were no significant differences in the other clinical or health related quality of life measures. Nurse led care resulted in significantly increased resource use compared with doctor led care (mean difference pound 1497, 95% confidence interval pound 688 to pound 2674, p<0.001), a large part of which resulted from the number and duration of hospital admissions. The mean difference in resource use was greater in the first year ( pound 2625) than in the second year ( pound 411).Nurse practitioner led care for stable patients within a chronic chest clinic is safe and is as effective as doctor led care, but may use more resources.
THE ULTRAFILTRABILITY OF POTASSIUM AND SODIUM IN HUMAN SERUM
Authors: Robert Tarail, Elaine S. Hacker, Robert Taymor
Journal: Journal of Clinical Investigation (1952)

One of the puzzling clinical aspects of the metabolism of electrolytes is the genesis of symptoms and signs of potassium depletion and potassium intoxication (1-3). Precipitous flaccid paralysis, sensory disturbances and respiratory failure, altogether analogous to the sequence of events in familial periodic paralysis, may occur in these disturbances of potassium metabolism characterized by either deficit or plethora of the ion. The preponderance of evidence indicates that such gross clinical derangements are observed in but a minority of instances of abnormality in the metabolism of potassium (1-9). Review of existing data, furthermore, fails to disclose a clinical, chemical, or physiologic difference which could account for the capricious incidence of serious manifestations in this minority of patients. The extensive metabolic studies of Jantz (10) in nine cases of familial periodic paralysis seem to afford a clue to the solution of this problem. He found that episodes of paralysis could be consistently related to a profound reduction in the ultrafiltrable fraction of plasma potassium. Although this finding has not been confirmed or negated, such an explanation might in part account for paralytic phenomena which occasionally supervene in patients without familial periodic paralysis, who develop disturbances of potassium metabolism. The present investigation comprises an analysis of the diffusibility in vitro of potassium and sodium of sera obtained from a group of normal subjects and an analogous preliminary survey of patients with derangements of electrolyte metabolism.
Effects of Antipsychotic Treatment on Polysomnographic Measures in Schizophrenia: A Replication and Extension
Authors: Susan Maixner, Rajiv Tandon, Alan Eiser, Stephan Taylor, John R. DeQuardo, James Shipley
Journal: American Journal of Psychiatry (1998)

Objective:The authors sought to replicate and extend previous observations of improvement in some EEG sleep measures during the course of antipsychotic treatment in schizophrenia patients. Method:Fourteen medication-free patients with schizophrenia underwent 2 nights of sleep EEG monitoring before and after 3–4 weeks of treatment with clinically determined doses of haloperidol or thiothixene.Results:Measures of sleep continuity improved consistently. REM latency increased, although five of 14 patients continued to exhibit short REM latencies (less than 60 minutes). Stage 3 sleep increased during neuroleptic treatment, while stage 4 sleep did not change.Conclusions:These data demonstrate partial improvement of some but not all EEG sleep measures in schizophrenic patients through the course of neuroleptic treatment. They suggest that shortened REM latency and disturbed sleep continuity might represent reversible state abnormalities, while reduced slow-wave sleep may represent a more persistent trait abnormality in schizophrenia. Am J Psychiatry 1998; 155: 1600-1602
Inflamed fat: what starts the fire?
Authors: J. G. Neels
Journal: Journal of Clinical Investigation (2005)

Obesity is associated with increased macrophage infiltration of adipose tissue, and these macrophages may be an important component of the chronic inflammatory response playing a crucial role in the development of insulin resistance. This prompts the question as to how macrophages infiltrate obese adipose tissue. In this issue of the JCI, Weisberg et al. show the importance of C-C motif chemokine receptor 2 (CCR2) in macrophage recruitment to adipose tissue and the development of obesity and its complications.
Liver abnormalities and liver membrane autoantibodies in systemic lupus erythematosus.
Authors: K Kushimoto, K Nagasawa, A Ueda, T Mayumi, Y Ishii, Y Yamauchi, Y Tada, H Tsukamoto, T Kusaba, Y Niho
Journal: Annals of the Rheumatic Diseases (1989)

The hepatic involvement of 57 patients with systemic lupus erythematosus (SLE) was studied with special reference to liver membrane autoantibody (LMA). Liver abnormalities were found predominantly in patients with active SLE (27/48 (56%) in active SLE v 3/20 (15%) in inactive SLE). They were, however, rather mild or moderate and tended to disappear as the disease activity of SLE decreased. In this respect the liver abnormalities observed in this study differed from those in patients with lupoid hepatitis. The incidence of LMA in active SLE (8/11 (73%] was significantly greater than that in inactive SLE (4/12 (33%)). The mean LMA index value in active SLE was 8.3, which was also greater than the 2.9 in inactive SLE. Furthermore, in active SLE the mean LMA titre was significantly higher in patients with liver abnormalities than in those without. These results suggest that LMA may be associated with the activity of SLE and may be one of the factors which cause transient liver abnormalities.
Unrecognised high pressure chronic retention of urine presenting with systemic arterial hypertension.
Authors: R. R. Ghose, V. Harindra
Journal: BMJ (1989)

A propos de 6 cas: hommes âgees de 50 a 70 ans, hospitalises pour hypertension arterielle. Les examens revelent une retention urinaire a une hypertrophie prostatique. Apres operation transuretrale, la retention d'urine et l'hypertension regressent; la creatinineurie d'urine, le debit plasmatique renal et la filtration glomenulaire augmentent
Abstract 2021: Aspirin Treatment Increases Scavenger Receptor Class B Type I Protein Expression in Human Carotid Atherosclerotic Plaques
Authors: Andreas Wehinger, Ivan Tancevski, Ruediger Seiler, Sandra M Frotschnig, Philipp Eller, Wilfried Schgoer, Bernhard Foeger, Josef R Patsch, Andreas Ritsch
Journal: Circulation (2006)

Introduction and Hypothesis - We have recently shown that aspirin promotes scavenger receptor class B type I (SR-BI) protein expression in vitro in primary human macrophages and in vivo in resident...
Licensing of International Medical Graduates-Reply
Authors: Arthur M. Osteen
Journal: JAMA (1992)

In Reply.  —Some state licensing boards do offer licenses based on eminence or on a determination that a physician is of international reputation. Some boards also provide licenses to graduates of foreign medical schools who have been appointed to US medical school faculty without requiring that they complete the years of graduate education otherwise required for a license.  The problem that boards confront in not requiring additional residency training for those physicians whose training is equal to, or more rigorous than, that
Ageing Research Reviews
Authors: I. R. Katz
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
UNUSUAL SITE OF TYPHOID PERFORATION
Authors: N. C. BLEDSOE
Journal: JAMA (1910)

<h3>History.—</h3> July 8, 1910, J. H. M., a hoisting engineer, married, aged 37, came to see me, giving a history of trouble with his stomach. His temperature was 102.6 F., pulse 100. A diagnosis of typhoid fever was made and he was sent to the hospital, where he ran a very high temperature. He was put on a milk diet, given phenyl salicylate 2½ grs.) every three hours and sponged for temperature above 102.5. He was blue, so he was given whisky (½ oz.) after each sponging. Rose spots appeared on the fifth day in the hospital; on the seventh day he had a severe hemorrhage from the bowels. The patient was given morphin (¼ gr.), and all food withheld for forty-eight hours. He was given all the ice-cold normal salt solution that he would drink (he never made any complaint about it). In twelve hours his temperature dropped to
Chemotherapy-Related Acute Rhabdomyolysis
Authors: C. PAPAKONSTANTINOU, K. PAPANASTASIOU, M. KOTSOPOULOU, M. MOURATIDOU, D. SOTIROPOULOS, M. C. KYRTSONI, A. POULI, M. STAMATELOU, A. MANIATIS
Journal: JNCI Journal of the National Cancer Institute (1992)

Chemotherapy-Related Acute RhabdomyolysisNontraumatic rhabdomyolysis can result from a variety of medical causes, e.g., alcoholism, drug abuse, infections, and metabolic derangement (/).The association of chemotherapy with rhabdomyolysis has rarely been reported (2j).We describe here a patient with acute leukemia in whom acute rhabdomyolysis developed shortly after initiation of chemotherapy.A previously healthy, 55-year-old woman was diagnosed with acute myelomonocytic leukemia in July 1990.Her treatment was begun with doxorubicin (80 mg/d given intravenously for 3 days), cytarabine (160 mg every 12 hours by continuous infusion for 7 days), thioguanine (200 mg/d given orally for 7 days), vincristine (1.5 mg given intravenously on days 1 and 7), and methylprednisolone (48 mg/d given orally).Twenty-four hours after the start of chemotherapy, she developed myalgia and a low-grade fever.No focus of infection could be detected, and treatment was continued after cultures were obtained.The following day, fever increased to 38.5 °C, the myalgia intensified, severe muscle tenderness, weakness, and edema developed, and the patient could move only with difficulty.Chemotherapy was discontinued.(She had received a total of 160 mg doxorubicin, 480 mg cytarabine, 360 mg thioguanine, and 1.5 mg vincristine.)Laboratory studies conducted 72 hours from the start of chemotherapy revealed the following values: serum creatine kinase, 2336 U/L (normal level, <100 U/L); lactic dehydrogenase, 235 U/L (normal level, <150 U/L); aspartate aminotransferase, 125 U/L (normal level, <29 U/L); alanine aminotransferase, 36 U/L (normal level, <33 U/L); and serum creatinine, 135 mmol/L.There was no myoglobinuria, and urine output remained normal with vigorous
Use of Premixed Pethidine and Antagonists in Obstetrical Analgesia
Authors: J. Bullough
Journal: BMJ (1959)

STOMACHBN^t 859 introduced intravenously on the first and second days after the operation, and each contains 0.2 mg./kg. of body weight.Regular estimation of leucocyte and platelet counts are performed.After discharge the patients are seen in the out-patient department every three months and examined for signs of recurrence.
Hypothalamic Hamartoma
Authors: David M. Judge, Howard E. Kulin, Robert Page, Richard Santen, Suriyonta Trapukdi
Journal: New England Journal of Medicine (1977)

The presence of a hypothalamic hamartoma and precocious puberty in a 19-month-old boy provided an opportunity to study their relation. Excised tissue had the ultrastructural characteristics of an independent neuroendocrine unit -- i.e., neurons containing neurosecretory granules and blood vessels with fenestrated endothelium and double basement membranes. Immunofluorescence studies using specific antibody to luteinizing-hormone-releasing factor showed antigenicity to the factor in the hamartoma. The testicular-hypothalamic-pituitary axis was tested. Clomiphene unresponsiveness suggested a lack of maturation of central-nervous-system events characteristic of normal puberty. The negative feedback system between gonad and brain was intact but partially resistant to steroid suppression. These studies suggest that hypothalamic hamartomas may cause precocious puberty by autonomous production and release of luteinizing-hormone-releasing factor into vessels that communicate with the pituitary portal blood system.
Blocking ETV6/RUNX1-induced MDM2 overexpression by Nutlin-3 reactivates p53 signaling in childhood leukemia
Authors: U Kaindl, M Morak, C Portsmouth, A Mecklenbräuker, M Kauer, M Zeginigg, A Attarbaschi, O A Haas, R Panzer-Grümayer
Journal: Leukemia (2013)

ETV6/RUNX1 (E/R) is the most common fusion gene in childhood acute lymphoblastic leukemia. It is responsible for the initiation of leukemia but also indispensable for disease maintenance and propagation, although its function in these latter processes is less clear. We therefore investigated the effects of the perceived p53 pathway alterations in model cell lines and primary leukemias and, in particular, how E/R upregulates MDM2, the predominant negative regulator of p53. We found that E/R transactivates MDM2 in both p53+/+ and p53−/− HCT116 cells by binding to promoter-inherent RUNX1 motifs, which indicates that this activation occurs in a direct and p53-independent manner. Treatment of E/R-positive leukemic cell lines with Nutlin-3, a small molecule that inhibits the MDM2/p53 interaction, arrests their cell cycle and induces apoptosis. These phenomena concur with a p53-induced expression of p21, pro-apoptotic BAX and PUMA, as well as caspase 3 activation and poly ADP-ribose polymerase cleavage. The addition of DNA-damaging and p53-activating chemotherapeutic drugs intensifies apoptosis. Moreover, Nutlin-3 exposure leads to an analogous p53 accumulation and apoptotic surge in E/R-positive primary leukemic cells. Our findings clarify the role of p53 signaling in E/R-positive leukemias and outline the potential basis for its therapeutic exploitation in this setting.
Prevalence of cardiovascular risk factors in rural and urban Costa Rica.
Authors: H Campos, L Mata, X Siles, M Vives, J M Ordovas, E J Schaefer
Journal: Circulation (1992)

BACKGROUND Coronary artery disease (CAD) is becoming more prevalent in developing countries, particularly in the urban areas, in contrast to the CAD mortality trends observed in some industrialized nations. METHODS AND RESULTS We determined the prevalence of cardiovascular risk factors (hypertension, diabetes, smoking, obesity, total cholesterol greater than or equal to 240 mg/dl and greater than or equal to 200 less than or equal to 239 mg/dl, low density lipoprotein (LDL) cholesterol greater than or equal to 160 mg/dl and greater than 130 less than or equal to 159 mg/dl, and high density lipoprotein (HDL) cholesterol less than 35 mg/dl) in 222 men and 243 women from rural and urban areas of Puriscal, Costa Rica, using the American Cholesterol Education Program guidelines. Urban Puriscal men had a significantly (p less than 0.05) higher prevalence of borderline high-risk total cholesterol (26% versus 14%), borderline high-risk LDL cholesterol (21% versus 11%), smoking (32% versus 13%), and higher prevalence of low HDL cholesterol (34% versus 24%), hypertension (16% versus 13%), diabetes (4.5% versus 2.7%), obesity (21% versus 14%), and saturated fat intake greater than 15% of calories (14% versus 7%) than rural men from Puriscal. No significant differences between rural and urban women were found for any of the cardiovascular risk factors. Urban Puriscal residents were also more sedentary than rural Puriscal residents. CONCLUSIONS These data indicate that modifiable risk factors are more prevalent in urban than in rural Puriscal, Costa Rica, particularly in men.
The Widower Surgeon’s Lament
Authors: Maria A. Basile
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia
Authors: Davide Rossi, Marco Fangazio, Silvia Rasi, Tiziana Vaisitti, Sara Monti, Stefania Cresta, Sabina Chiaretti, Ilaria Del Giudice, Giulia Fabbri, Alessio Bruscaggin, Valeria Spina, Clara Deambrogi, Marilisa Marinelli, Rosella Famà, Mariangela Greco, Giulia Daniele, Francesco Forconi, Valter Gattei, Francesco Bertoni, Silvia Deaglio, Laura Pasqualucci, Anna Guarini, Riccardo Dalla-Favera, Robin Foà, Gianluca Gaidano
Journal: Blood (2012)