Serum Lactic Dehydrogenase Activity and Radioactive Lung Scanning in the Diagnosis of Pulmonary Embolism
Authors: ELIAS AMADOR
Journal: Annals of Internal Medicine (1966)

Article1 December 1966Serum Lactic Dehydrogenase Activity and Radioactive Lung Scanning in the Diagnosis of Pulmonary EmbolismELIAS AMADOR, M.D., E. JAMES POTCHEN, M.D.ELIAS AMADOR, M.D.Search for more papers by this author, E. JAMES POTCHEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-6-1247 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe serum lactic dehydrogenase (LDH) activity is an accurate and sensitive tool for the detection and diagnosis of certain life-threatening cardiovascular diseases such as myocardial infarction and pulmonary embolism (1, 2). In the case of pulmonary embolism the high mortality has led to a critical evaluation of traditional methods employed for diagnosis with the findings that they have a limited diagnostic accuracy (3, 4). In contrast, studies of the serum LDH activity have shown that a persistently elevated LDH activity appears to be a sensitive and consistent index of pulmonary embolism (5-8); however, it is not specific per se.Pulmonary...References1. WACKERULMERVALLEE WEDDBL: Metalloenzymes and myocardial infarction. II. Malic and lactic dehydrogenase activities and zinc concentrations in serum. New Eng. J. Med. 255: 449, 1956. CrossrefGoogle Scholar2. WACKERSNODGRASS WEPJ: Serum LDH activity in pulmonary embolism diagnosis. JAMA 174: 2142, 1960. CrossrefMedlineGoogle Scholar3. COONCOLLER WWFA: Clinicopathologic correlation in thromboembolism. Surg. Gynec. Obstet. 109: 259, 1959. MedlineGoogle Scholar4. KRAUSESILVERBLATT SM: Pulmonary embolism: a review with emphasis on clinical and electrocardiographic diagnosis. Arch. Intern. Med. (Chicago) 96: 19, 1955. CrossrefGoogle Scholar5. 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Author, Article, and Disclosure InformationAffiliations: Boston, MassachusettsFrom the Departments of Pathology and Radiology of the Harvard Medical School at the Peter Bent Brigham Hospital, Boston, Mass.At the time of this study Dr. Amador was a Fellow of the Medical Foundation, Inc., Boston, Mass., and Dr. Potchen was a James Picker Foundation Fellow in Academic Radiology.Requests for reprints should be addressed to Elias Amador, M.D., Institute of Pathology, Western Reserve University, 2085 Adelbert Rd., Cleveland, Ohio 44106. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySerum LDH in chronic cough: a potential marker of airway inflammationUtility of serum LDH isoforms in the assessment of mycobacterium tuberculosis induced pathology in TB patients of Sahariya tribe1 Clinical EnzymologyKrankheiten der Atemwege und des MediastinumsREFERENCESKrankheiten der Atemwege und des MediastinumsProblems in the diagnosis and management of pulmonary embolismLactic dehydrogenase isoenzymes after electroshock treatment of cardiac arrhythmiasAcute pulmonary embolismSERUM LACTATE DEHYDROGENASE AND PULMONARY EMBOLISMAARNE KONTTINEN, M.D. 1 December 1966Volume 65, Issue 6Page: 1247-1255KeywordsCardiovascular diseasesDehydrogenasesDiagnostic radiologyIschemiaLactate dehydrogenaseLungsMortalityMyocardial infarctionPneumoniaPulmonary embolism Issue Published: 1 December 1966 PDF DownloadLoading ...