Colon Polyps in Acromegaly
Authors: Shereen Ezzat, Carey Strom, Shlomo Melmed
Journal: Annals of Internal Medicine (1991)

Brief Reports1 May 1991Colon Polyps in AcromegalyShereen Ezzat, MD, Carey Strom, MD, Shlomo Melmed, MDShereen Ezzat, MDSearch for more papers by this author, Carey Strom, MDSearch for more papers by this author, Shlomo Melmed, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-9-754 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcromegaly results from unrestrained secretion of growth hormone and insulin-like growth factor 1 (IGF-1), usually occurring as a result of a pituitary somatotroph adenoma (1). Of 283 acromegalic patients retrospectively examined, 13 have been reported to have adenocarcinoma of the colon (2). Klein and associates (3) screened 17 patients with acromegaly for colonic lesions. Nine patients were identified with polyps, 5 of whom had adenomatous lesions. These results prompted us to prospectively examine the association of colonic polyps and acromegaly in patients with hypersomatotropism with no other identifiable risk factors for colon neoplasia. We chose complete colonoscopy as our screening...References1. Melmed S. Acromegaly. N Engl J Med. 1990;322:966-77. CrossrefMedlineGoogle Scholar2. EzzatMelmed SS. Are patients with acromegaly at increased risk for neoplasia? J Clin Endocrinol Metab. 1991;72:245-9. CrossrefMedlineGoogle Scholar3. KleinParveenGavalerVanthiel IGJD. Colonic polyps in patients with acromegaly. Ann Intern Med. 1982;97:27-30. LinkGoogle Scholar4. Cannon-AlbrightSkolnickBishopLeeBurt LMDRR. Common inheritance of susceptibility to colonic adenomatous polyps and associated colorectal cancers. N Engl J Med. 1988;319:533-7. CrossrefMedlineGoogle Scholar5. BrunnerJohnsonZafarPetersonBrunnerMelliner JCSEJR. Colon cancer and polyps in acromegaly: increased risk associated with family history of colon cancer. Clin Endocrinol (Oxf). 1990;32:65-71. CrossrefMedlineGoogle Scholar6. MoonSimpsonLiEvans HMCH. Neoplasms in rats treated with pituitary growth hormone I. Pulmonary and lymphatic tissues. Cancer Res. 1950;10:297-308. MedlineGoogle Scholar7. Daughaday W. The possible autocrine/paracrine and endocrine roles of insulin-like growth factors of human tumors. Endocrinology. 1990;127:1-4. CrossrefMedlineGoogle Scholar8. MurphyBellFriesen LGH. Growth hormone stimulates sequential induction of c-myc and insulin-like growth factor I expression in vivo. Endocrinology. 1987;120:1806-12. CrossrefMedlineGoogle Scholar9. SmithSolomon JT. Effects of gastrin, proglumide, and somatostatin on growth of human colon cancer. Gastroenterology. 1988;95:1541-8. CrossrefMedlineGoogle Scholar10. FearonVogelstein EB. A genetic model for colorectal tumorigenesis. Cell. 1990;61:759-67. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From Cedars-Sinai Medical Center-UCLA School of Medicine, Los Angeles, California. For current author addresses, see end of text. 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Smith, MD 1 May 1991Volume 114, Issue 9Page: 754-755KeywordsAcromegalyColonColonoscopyEndocrinologyGrowth hormoneInsulin like growth factor 1Insulin-like growth factorsLesionsMedical risk factorsPituitary adenoma Issue Published: 1 May 1991 PDF downloadLoading ...