tbuckley/cabot-search huggingface dataset:
Syncope
Authors: David F. Katz, Paul D. Varosy, Frederick A. Masoudi
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
A CASE of TRUE HAeMATOSALPINX: LAPAROTOMY: RECOVERY
Authors: J. Griffiths
Journal: BMJ (1896)

rupted, and she was allowed up on the tenth day.The material removed showed hundreds of cyst-like forma- tions, some about the size of peas or currants, others very small, like pinheads; each contained a clear jelly-like fluid, giving the appearance of small white berries.The case was thus, undoubtedly, one of vesicular or hydatidiform degeneration of the placenta.It will be noticed that the cardinal symptoms of the disease were all present:i.The more rapid development of the uterus than occurs in ordinary pregnancy.2. The repeated attacks of uterine heemolrhage.3. The disappearance of the embryo.4. In this case the absence of " ballottement " was somewhat suggestive.
Authors' reply to Chapman
Authors: C. D. Hanning, A. Evans
Journal: BMJ (2012)

Chapman insinuates that our histories of anti-wind farm activity automatically invalidate our opinions.1 2 We are not against wind farms in general, only those placed too close to human habitation, a public health objective that should surely meet with his approval. As a member of the Climate and Health Alliance, which advocates renewable energy, Chapman could be described as having a …
Does the world need the BMJ?
Authors: R. Smith
Journal: BMJ (1997)

To consider whether the world would be different if your institution disappeared is a sharper exercise than to compose its mission statement. Would the world miss the BMJ ? The day that the BMJ is redesigned seems a good time for us to try to answer that question.

Nobody would start a new general medical journal today, and many that exist are beginning to disappear. Information scientists argue that there are too many journals, that much of what they publish is of poor quality, and that important material may be lost in a welter of the unimportant: the “signal to noise” ratio is horribly low.1 Meanwhile, enthusiasts for the Internet curse the slowness and exclusivity of paper journals and predict their imminent demise.2 They want a world where authors go directly to readers unimpeded by editors. The BMJ 's environment may not thus seem inviting, but that is nothing new–of the hundreds of journals started at the same time as the BMJ (1840) only a handful survive.

The first thing to get clear is what the BMJ is. For many readers it is that “blue mag” that pops up once a week, but the BMJ is more than that. It is also the Student BMJ , 20 local editions (in countries ranging from Brazil to Poland, many in local languages), a version on the worldwide web, and two different classified advertisement supplements. In the future readers might encounter BMJ material in other forms, and we are currently planning an electronic version that will be interactive and will use all the possibilities of the …
Extended-Duration Venous Thromboembolism Prophylaxis in Acutely Ill Medical Patients With Recently Reduced Mobility
Authors: Russell D. Hull
Journal: Annals of Internal Medicine (2010)

Background: Extended-duration low-molecular-weight heparin has been shown to prevent venous thromboembolism (VTE) in high-risk surgical patients. Objective: To evaluate the efficacy and safety of extended-duration enoxaparin thromboprophylaxis in acutely ill medical patients. Design: Randomized, parallel, placebo-controlled trial. Randomization was computer-generated. Allocation was centralized. Patients, caregivers, and outcome assessors were blinded to group assignment. (ClinicalTrials.gov registration number: NCT00077753) Setting: 370 sites in 20 countries across North and South America, Europe, and Asia. Patients: Acutely ill medical patients 40 years or older with recently reduced mobility (bed rest or sedentary without [level 1] or with [level 2] bathroom privileges). Eligibility criteria for patients with level 2 immobility were amended to include only those who had additional VTE risk factors (age >75 years, history of VTE, or active or previous cancer) after interim analyses suggested lower-than-expected VTE rates. Intervention: Enoxaparin, 40 mg/d subcutaneously (2975 patients), or placebo (2988 patients), for 28 ± 4 days after receiving open-label enoxaparin for an initial 10 ± 4 days. Measurements: Incidence of VTE up to day 28 and of major bleeding events up to 48 hours after the last study treatment dose. Results: Extended-duration enoxaparin reduced VTE incidence compared with placebo (2.5% vs. 4%; absolute risk difference favoring enoxaparin, −1.53% [95.8% CI, −2.54% to −0.52%]). Enoxaparin increased major bleeding events (0.8% vs. 0.3%; absolute risk difference favoring placebo, 0.51% [95% CI, 0.12% to 0.89%]). The benefits of extended-duration enoxaparin seemed to be restricted to women, patients older than 75 years, and those with level 1 immobility. Limitation: Estimates of efficacy and safety for the overall trial population are difficult to interpret because of the change in eligibility criteria during the trial. Conclusion: Use of extended-duration enoxaparin reduces VTE more than it increases major bleeding events in acutely ill medical patients with level 1 immobility, those older than 75 years, and women. Primary Funding Source: Sanofi-aventis.
Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes
Authors: Jill Henault, Jennifer Martinez, Jeffrey M. Riggs, Jane Tian, Payal Mehta, Lorraine Clarke, Miwa Sasai, Eicke Latz, Melanie M. Brinkmann, Akiko Iwasaki, Anthony J. Coyle, Roland Kolbeck, Douglas R. Green, Miguel A. Sanjuan
Journal: Immunity (2012)
Multiple Acquired Renal Carcinoma Tumor Capabilities Abolished upon Silencing of ADAM17
Authors: Aleksandra Franovic, Isabelle Robert, Karlene Smith, Ghada Kurban, Arnim Pause, Lakshman Gunaratnam, Stephen Lee
Journal: Cancer Research (2006)

Abstract Malignancy is a manifestation of acquired defects in regulatory circuits that direct normal cell proliferation and homeostasis. Most of these circuits operate through cell autonomous pathways, whereas others potentially involve the neighboring microenvironment. We report that the metalloprotease ADAM17 plays a pivotal role in several acquired tumor cell capabilities by mediating the availability of soluble transforming growth factor-α, an epidermal growth factor receptor (EGFR) ligand, and thus the establishment of a key autocrine signaling pathway. Silencing of ADAM17 in human renal carcinoma cell lines corrects critical features associated with cancer cells, including growth autonomy, tumor inflammation, and tissue invasion. Highly malignant renal carcinoma cancer cells fail to form in vivo tumors in the absence of ADAM17, confirming the essential function of this molecule in tumorigenesis. These data show that ligand shedding is a crucial step in endogenous EGFR activation and endorse prospective therapeutic strategies targeting ADAM17 in human cancer. (Cancer Res 2006; 66(16): 8083-90)
Global and regional myocardial oxygen consumption and blood flow in severe cardiomyopathy with left bundle branch block
Authors: Oliver Lindner, Jürgen Vogt, Detlev Baller, Annett Kammeier, Peter Wielepp, Jens Holzinger, Barbara Lamp, Dieter Horstkotte, Wolfgang Burchert
Journal: European Journal of Heart Failure (2004)
Pathophysiology of Malaria
Authors: MARCEL E. CONRAD
Journal: Annals of Internal Medicine (1969)

Clinical malaria does not occur without hemolysis and parasitemia of circulating erythrocytes. Different metabolic requirements of various malarial strains cause species specificity and alter morbidity. Hemolysis does not seem to be caused by antibodies or hypersplenism. It is postulated that hemolysis is caused by loss of negative charge from the surface of red blood cells because the parasite usurps essential metabolic functions of the infected erythrocyte. Hemolysis in excess of the number of observed parasitized erythrocytes may be caused by splenic pitting of parasites from infected red blood cells and the return of damaged spherocytes with a shortened survival to the circulation. The demonstration of accelerated intravascular coagulation in malaria provides an explanation for the occurrence of both thrombosis and hemorrhage in multiple body organs. Heparin therapy seems to improve the morbidity and mortality of malaria and decrease parasitemia.
Meeting Report: Risk Assessment of Tamiflu Use Under Pandemic Conditions
Authors: Andrew C. Singer, Bruce M. Howard, Andrew C. Johnson, Chris J. Knowles, Simon Jackman, Cesare Accinelli, Anna Barra Caracciolo, Ian Bernard, Stephen Bird, Tatiana Boucard, Alistair Boxall, Jayne V. Brian, Elise Cartmell, Chris Chubb, John Churchley, Sandra Costigan, Mark Crane, Michael J. Dempsey, Bob Dorrington, Brian Ellor, Jerker Fick, John Holmes, Tom Hutchinson, Franz Karcher, Samuel L. Kelleher, Peter Marsden, Gerald Noone, Miles A. Nunn, John Oxford, Tony Rachwal, Noel Roberts, Mike Roberts, Maria Ludovica Saccà, Matthew Sanders, Jürg Oliver Straub, Adrian Terry, Dean Thomas, Stephen Toovey, Rodney Townsend, Nikolaos Voulvoulis, Chris Watts
Journal: Environmental Health Perspectives (2008)

On 3 October 2007, 40 participants with diverse expertise attended the workshop Tamiflu and the Environment: Implications of Use under Pandemic Conditions to assess the potential human health impact and environmental hazards associated with use of Tamiflu during an influenza pandemic. Based on the identification and risk-ranking of knowledge gaps, the consensus was that oseltamivir ethylester-phosphate (OE-P) and oseltamivir carboxylate (OC) were unlikely to pose an ecotoxicologic hazard to freshwater organisms. OC in river water might hasten the generation of OC-resistance in wildfowl, but this possibility seems less likely than the potential disruption that could be posed by OC and other pharmaceuticals to the operation of sewage treatment plants. The work-group members agreed on the following research priorities: a) available data on the ecotoxicology of OE-P and OC should be published; b) risk should be assessed for OC-contaminated river water generating OC-resistant viruses in wildfowl; c) sewage treatment plant functioning due to microbial inhibition by neuraminidase inhibitors and other antimicrobials used during a pandemic should be investigated; and d) realistic worst-case exposure scenarios should be developed. Additional modeling would be useful to identify localized areas within river catchments that might be prone to high pharmaceutical concentrations in sewage treatment plant effluent. Ongoing seasonal use of Tamiflu in Japan offers opportunities for researchers to assess how much OC enters and persists in the aquatic environment.
THE USE OF CELLULOID IN THE CORRECTION OF NASAL DEFORMITIES
Authors: G. B. NEW
Journal: JAMA (1918)

For many years it has been the general practice to use a piece of bone from the tibia, rib or scapula, or a piece of cartilage from a rib, for an autogenous transplant in the correction of deformities of the nose resulting from trauma or syphilis. In carrying out this method the wound necessarily made where the transplant is taken causes more inconvenience to the patient than does the nasal wound. During the past year I have used celluloid as an implant into the tissue over the nose in a series of dogs, and in five cases in man. The results have been so satisfactory that the use of celluloid seems preferable to that of cartilage or bone. The necessity of taking a transplant is thereby eliminated and the operation simplified. In 1908, Koschier<sup>1</sup>reported two cases of nasal deformity in which he used thin celluloid plates, and he
Child Health and Development
Authors: J. C. Haworth
Journal: JAMA (1966)

This is the fourth edition of a book first published in 1947. There are 18 contributors, mostly from Scottish centers, and many are widely recognized experts in their fields. The first part of the book, dealing with development, opens with an excellent and clearly expressed chapter on the genetic aspects, by F. A. E. Crew. Other chapters discuss the development of the fetus and the physical, behavioral, and emotional development of the newborn infant and older child. However, with the exception of a very good chapter on prematurity and low birthweight, by C. M. Drillien, there is a good deal of overlapping and lack of cohesion in this part, and one could wish that the editor had taken a firmer hand. The emphasis is very largely clinical and recent advances in physiological, biochemical, and immunologic development are merely touched upon or ignored. This is especially noticeable in the chapter on
Clinical and hemodynamic results of mitral valve replacement with autologous fascia lata grafts. Studies in patients with competent prostheses.
Authors: S H Taylor, M C Galvin, B C Pakrashi, A T Tulpule, M I Ionescu, W Whitaker
Journal: Circulation (1975)

Nine patients with severe mitral disease were studied before and six months after mitral valve replacement with a three-cusp stented prosthesis using fresh autologous fascia lata tissue. Only patients in whom there was no auscultatory and angiographic evidence of incompetence of the replaced valve were selected for restudy. All patients claimed a marked improvement in their exercise capacity after operation and there was a significant reduction in radiographic heart size. The cardiac output at rest and the response to exercise were both reduced before operation and were unchanged after valve replacement. The elevated pulmonary arterial and wedge pressures were significantly reduced after operation in all patients both at rest and during exercise, but in no instance were the postoperative exercise values within normal limits. Left ventricular end-diastolic pressure was within normal limits at rest and during exercise in all patients after valve replacement but the average pressure gradient across the fascia lata valve was 6+/-1 mm Hg at rest and 18+/-3 mm Hg during exercise. These findings indicate that altough replacement of the diseased mitral valve with a competent fascia lata prosthesis afforded substantial symptomatic relief, reduction of cardiac enlargement and a lowering of the pulmonary vascular pressures, this artificial valve offered a significant obstruction to left ventricular diastolic filling, particularly during exercise.
The Perinatal Situation
Authors: B. Gans
Journal: BMJ (1966)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following The Perinatal Situation Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Pathway of free fatty acid oxidation in human subjects. Implications for tracer studies.
Authors: L S Sidossis, A R Coggan, A Gastaldelli, R R Wolfe
Journal: Journal of Clinical Investigation (1995)

To determine the pathway of plasma FFA oxidation and the site(s) of label fixation observed during infusion of FFA tracers, [1-13C]palmitate and [1-14C]acetate were infused intravenously for 3 h in five volunteers. Breath 13CO2 enrichment and 14CO2 specific activity were followed for 6 h to determine the labeled CO2 decay rates. Acetate enters directly into the TCA cycle; hence, if palmitate transits a large lipid pool before oxidation, 13CO2 enrichment (from palmitate) should decay slower than 14CO2 specific activity (from acetate). Breath 13CO2 enrichment and 14CO2 specific activity decayed at a similar rate after stopping the tracer infusions (half-lives of 13CO2 and 14CO2 decay: mean [+/- SE] 106.6 +/- 8.9 min, and 96.9 +/- 6.0 min, respectively, P = NS), which suggests that palmitate enters the TCA cycle directly and that label fixation occurs after citrate synthesis. Significant label fixation was shown in plasma glutamate/glutamine and lactate/pyruvate during infusion of either [1,2-13C]acetate or [U-13C]palmitate, suggesting that TCA cycle exchange reactions are at least partly responsible for label fixation. This was consistent with our finding that the half-lives of 13CO2 enrichment and 14CO2 specific activity decreased significantly during exercise to 14.4 +/- 3 min and 16.8 +/- 1 min, respectively, since exercise significantly increases the rate of the TCA cycle in relation to that of the TCA cycle exchange reactions. We conclude that plasma FFA entering cells destined to be oxidized are directly oxidized and that tracer estimates of plasma FFA oxidation will underestimate the true value unless account is taken of the extent of label fixation.
Safety and efficacy of peginterferon-α2a plus ribavirin treatment in renal transplant recipients with chronic hepatitis C
Authors: Faisal M. Sanai, Dujana Mousa, Abdallah Al-Mdani, Ghada Al-Shoail, Hamad Al-Ashgar, Khalid Al Meshari, Ahmed Al-Qahtani, Mayssa Saadeh, Khalid I. Bzeizi, Hassan Aleid
Journal: Journal of Hepatology (2013)
CANGRELOR IN ELDERLY PATIENTS UNDERGOING PCI: FINDINGS FROM CHAMPION-PHOENIX
Authors: Matthew Cavender, Deepak Bhatt, Gregg Stone, Philippe Steg, C. Michael Gibson, Christian Hamm, Matthew Price, Jayne Prats, Tiepu Liu, Efthymios Deliargyris, Kenneth Mahaffey, Harvey White, Robert Harrington
Journal: Journal of the American College of Cardiology (2015)
SPUTUM EXAMINATION IN SO-CALLED CLOSED TUBERCULOSIS
Authors: Emery Szucs
Journal: JAMA (1926)

Among others, we classify tuberculous patients as open and closed cases, based on the presence or absence of expectoration. Our recent observations made on two patients of the Mount Pleasant Sanatorium make it appear doubtful whether this classification based on apparent absence of expectoration is justified. In having done so, we failed to recognize that apparently closed cases may be in fact open cases and a source of infection. We succeeded in demonstrating the presence of tubercle bacilli in the spray of two of our recently admitted patients in the absence of any expectoration. There was an extensive tuberculous involvement present in both of our cases, of acute and subacute character, respectively. The patients were advised to report immediately the slightest amount of expectoration and though our observation covered from four to eight weeks, we were unable to obtain a sputum specimen for examination. We used the following simple technic:
HIGH PREVALENCE OF INFLIXIMAB RELATED LUPUS LIKE SYNDROME IN IRISH IBD COHORT- REAL LIFE PREVALANCE OR RANDOM CLUSTER?
Authors: L M Jackson, W A Stack, J McCarthy, U Lannin, J O Keefe
Journal: Gut (2013)

<h3>Introduction</h3> Lupus like syndrome is a rarely reported adverse event for Anti TNF therapies (1) We noted a significant number of adverse events in particular drug induced SLE like syndrome (DILE) amongst our IBD patients receiving infliximab. <h3>Aims/Background</h3> The aim of this study was to quantify the real life prevalence of significant side effects and in particular lupus like syndrome to infliximab therapy. <h3>Method</h3> We reviewed retrospectively notes of all patients receiving infliximab therapy between Sep 2009 and Sep 2012 in GI unit. <h3>Results</h3> 327 no of infusions was given to 39 patients (16 Crohns /23 UC, M:F ratio 21:18) over study period. 24/37 (64.8%) patients stopped therapy in that period after a median of 4(1–12) infusions. 30.4% (7/23) patients stopped therapy in setting of clinical remission. 17.4% ( 4/23) patients stopped therapy because of treatment failure. (11/37 (29.7%) patients stopped treatment because of significant side effects. (3/37 8.1%) experienced acute infusion reaction, 1/37 (2.7%) MS. 5/37 (13.5%) patients manifested lupus like syndrome, 2/37 (5.4%) hilar adenopathy on CXR with strongly pos. ANA and antidsDNA. Older age at diagnosis (47 vs. 32) yrs. predicted increased risk of developing lupus like syndrome (p&lt;0.05) as did history of previous azathioprine intolerance (100 vs. 43) % (p&lt;0.05). <h3>Conclusion</h3> We report a higher than previously reported prevalence of DILE with anti-TNF therapy in an Irish cohort of IBD patients. Future studies are required to determine if this represents a cluster or predicts a real life higher prevalence in Irish population.
Withdrawal by HJSC from the Review Body.
Authors: J N Johnson
Journal: BMJ (1978)

Chaos caused by maternity leave regulations SIR,-Doctors, like other NHS employees, are potentially eligible for both Whitley Council maternity leave and Employment Protection Act maternity leave.The conditions which have to be fulfilled for entitlement are different for the two sets of provisions.This means that some employees are eligible for both types of leave, some for Whitley Council, some for EPA provisions, and some for none.Routine intervention by "expert" advisers should not be necessary to interpret maternity regulations, but it is necessary at the moment.To avoid this the Medical Women's Federation proposes that the Whitley Council regulations be amended, as a matter of urgency, so that they do not conflict with EPA provisions.
Ineffective hemopoietic in beta thalassemia major visualised
Authors: Balkrishna Padate, Barbara J. Bain, Josu de la Fuente
Journal: American Journal of Hematology (2010)

The anaemia in beta thalassemia major is multifactorial. It is in part due to the defect in globin chain synthesis leading a hypochromic microcytic anemia, in part due to a shortened red cell survival and in part due to ineffective erythropoiesis. Ineffective erythropoiesis is the result of alpha chain deposition in erythroblasts, which leads to apoptosis and ingestion of erythroblasts by macrophages. It is the hyperplastic ineffective erythropoiesis that is responsible for many of the pathological effects of untreated or undertreated thalassemia major. The bone marrow aspirate films illustrated are from a boy with beta thalassemia major, aged 3 years 6 months, who had been regularly transfused from the age of 6 months. He had been on chelation therapy with subcutaneous deferoxamine (desferrioxamine) 6 nights a week from the age of 18 months with the most recent serum ferritin being 1800 μg/l. Hepatic iron was 4.4 mg/g. The bone marrow aspiration was performed prior to a hemopoietic stem cell transplant. The May–Grünwald–Giemsa-stained film (left) shows hyperplastic erythropoiesis and two macrophages containing ingested erythroblasts and cellular debris. The Perls-stained film (right) shows iron-laden macrophages containing multiple ingested erythroblasts. The films provide a visual representation of the ineffective erythropoiesis of beta thalassemia major, showing the striking death of bone marrow erythroblasts. The macrophages are their graveyard.