Granulocyte Reserve in Cancer and Malnutrition
Authors: LODOVICO BALDUCCI
Journal: Annals of Internal Medicine (1983)

Brief Reports1 May 1983Granulocyte Reserve in Cancer and MalnutritionLODOVICO BALDUCCI, M.D., DIANA D. LITTLE, R.N., B.S.N., NANCY G. GLOVER, R.D., CHERYL S. HARDY, Ph.D., MARTIN H. STEINBERG, M.D.LODOVICO BALDUCCI, M.D.Search for more papers by this author, DIANA D. LITTLE, R.N., B.S.N.Search for more papers by this author, NANCY G. GLOVER, R.D.Search for more papers by this author, CHERYL S. HARDY, Ph.D.Search for more papers by this author, MARTIN H. STEINBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-5-610 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDrug-induced myelotoxicity is a major limiting factor in effective cancer treatment (1). Cancer and protein calorie malnutrition associated with cancer may cause hematopoietic depression and enhance the myelotoxicity of cycle-active antineoplastic agents (2, 3).Granulocytopoiesis, which is commonly affected by chemotherapy, may be estimated by measuring the granulocyte reserve (4). We compared the granulocyte reserve of malnourished and well nourished patients with and without associated cancer to establish whether malnutrition and cancer are independent factors affecting granulocyte reserve.Forty one men, ages 49 to 74 years, were studied, 24 of whom were malnourished. Twenty-one patients had metastatic cancer, 13 of...References1. CHABNERMYERS BC. Clinical pharmacology of cancer chemotherapy. In: DE VITA V, HELLMAN S, ROSENBERG SA, eds. Cancer Principles and Practice of Oncology. Philadelphia and Toronto: J. B. Lippincott; 1982:156-97. Google Scholar2. ZUCKERLYSIKDISTEFANO SRJ. Cancer cell inhibition of erythropoiesis. J Lab Clin Med. 1980;96:770-82. MedlineGoogle Scholar3. FRIEDSHAPIROBARONEANAGNOSTOU SSJA. Effect of protein deprivation of hematopoietic stem cells and on peripheral blood counts. J Lab Clin Med. 1978;92:303-10. MedlineGoogle Scholar4. MASONLESSINSCHECHTER BLG. Marrow granulocyte reserves in black Americans: hydrocortisone-induced granulocytosis in the "benign" neutropenia of the black. Am J Med. 1979;67:201-5. CrossrefMedlineGoogle Scholar5. NIXONHEYMSFIELDCOHEN DSA. Protein-calorie undernutrition in hospitalized cancer patients. Am J Med. 1980;68:683-90. CrossrefMedlineGoogle Scholar6. KEPPEL G. Design and Analysis: A Researcher's Handbook. Englewood Cliffs, New Jersey: Prentice-Hall, Inc. ; 1973:177. Google Scholar7. DUNN O. Multiple comparisons using rank sums. Technometrics. 1964;6:241-51. CrossrefGoogle Scholar8. EVANSCLAMMONFELD WGR. Long-term effects of hyperalimentation (TPN) on nutritional indices of patients with small cell lung cancer. In: Proceedings of the 18th Annual Meeting of the American Society of Clinical Oncology. Baltimore: Waverly Press; 1982:C-245. Google Scholar9. NIXONLAWSONKUTNER DDM. Hyperalimentation of the cancer patient with protein calorie undernutrition. Cancer Res. 1981;41:2038-45. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Jackson Veterans Administration Medical Center Jackson, Mississippi. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySerum Total Bilirubin as a Predictive Factor for Severe Neutropenia in Lung Cancer Patients Treated with Cisplatin and IrinotecanNutritional Support in Patients with Cancer of the Esophagus: Impact on Nutritional Status, Patient Compliance to Therapy, and SurvivalEnteral nutritional support by gastrostomy tube in children with cancerLeukaemia and nutrition I: Malnutrition is an adverse prognostic factor in the outcome of treatment of patients with standard-risk acute lymphoblastic leukaemiaLow incidence of peripheral blood haematopoietic stem cells in patients with anorexia nervosaNutritional factors in gastrointestinal cancerNutritional Support of Children with Neoplastic DiseasesReview: Hemopoietic Alterations of CancerCancer and malnutrition—A critical interaction: A reviewAssessment of MalnutritionPAUL JAY FRIEDMAN, M.D.Infectious Diseases and Aging: Immunologic Perspectives 1 May 1983Volume 98, Issue 5_Part_1Page: 610-611KeywordsCancer treatmentChemotherapyDrugsGranulocytesMalnutritionProteins Issue Published: 1 May 1983 PDF downloadLoading ...