tbuckley/cabot-search huggingface dataset:
Zinc abuse and sideroblastic anemia
Authors: Jayanthi Ramadurai, Charles Shapiro, Mark Kozloff, Margaret Telfer
Journal: American Journal of Hematology (1993)

Abstract We report the case of a young woman who presented with anemia and leukopenia. A bone marrow aspirate, revealed a marked excess of ringed sideroblasts. A detailed dietary history disclosed excessive zinc intake. High serum zinc and low serum copper concentrations were confirmed. After discontinuation of the zinc supplements, she made a complete hematologic recovery. This report emphasises the importance of trace metals and their rote in the development of hematologic abnormalities. © 1993 Wiley‐Liss, Inc.
Renovascular Hypertension: Treatment by Percutaneous Transluminal Dilatation
Authors: U. KUHLMANN, W. VETTER, J. FURRER, U. LÜTOLF, W. SIEGENTHALER, A. GRÜNTZIG
Journal: Annals of Internal Medicine (1980)

Eight patients with unilateral renovascular hypertension underwent percutaneous transluminal dilatation. In seven, renal-artery stenoses were caused by atherosclerotic lesions and in one, by fibromuscular hyperplasia. After a 6-month follow-up period, three patients were cured of hypertension and four showed improvement. Only one patient failed to respond: Failure was caused by an occluded left renal artery 3 months after the procedure. Renal angiographic studies were repeated in six patients after 6 months of follow-up and showed patent vessels in five and reoccurrence of a slight renal-artery stenosis in one. In one patient angiographic control studies done after 3 months showed an occluded renal artery. In five patients mean pressure gradient across the renal-artery stenoses was 89 ± 22.8 mm Hg before percutaneous transluminal dilatation and 16.4 ± 18.5 mm Hg after being controlled for 6 months. Our results indicate that percutaneous transluminal dilatation may be valuable in the treatment of renovascular hypertension.
Endoscopic Treatment of the Hypopharyngeal Diverticulum with the CO<sub>2</sub>Laser
Authors: P.P. Knegt, P.C. de Jong, E.J. van der Schans
Journal: Endoscopy (1985)

Diathermic coagulation and cutting in the endoscopic treatment of hypopharyngeal diverticula was replaced by CO2 laser evaporation. Endoscopic laser surgery was performed in 37 patients, with complete or almost complete relief in all cases. The rate of complications is low.
Vascular cell adhesion molecule-1 (VCAM-1) plays a central role in the pathogenesis of severe forms of vasculitis due to hepatitis C-associated mixed cryoglobulinemia
Authors: Gilles Kaplanski, Thierry Maisonobe, Valérie Marin, Sandra Grès, Stéphane Robitail, Catherine Farnarier, Jean-Robert Harlé, Jean-Charles Piette, Patrice Cacoub
Journal: Journal of Hepatology (2005)
CNS Effects of Mechanical Ventilation
Authors: Brendan Phibbs
Journal: JAMA (1964)

<h3>To the Editor:—</h3> This is a comment regarding "CNS Disorder During Mechanical Ventilation in Chronic Pulmonary Disease" by Rotheram et al (<i>JAMA</i><b>189:</b>993 [Sept 28] 1964). Our experience with mechanical ventilation at the Cardiovascular Research Unit, Natrona County Memorial Hospital, confirms the observations of these authors. During the past three years we have repeatedly seen episodes of mental confusion and several mild convulsive episodes which we attributed to the alkalosis which inevitably follows any significant hyperventilation. We have found that administration of ammonium chloride early in the course of ventilation therapy averts the difficulty, and we have made this a part of our routine management of pulmonary insufficiency. Adequate doses of an acid drug started within the first 48 hours have appeared to be completely effective in preventing such episodes. Since these people are usually edematous, the diuretic effect of ammonium chloride is a welcome therapeutic bonus in any
Adjunctive Antidepressant Use and Symptomatic Recovery Among Bipolar Depressed Patients With Concomitant Manic Symptoms: Findings From the STEP-BD
Authors: Joseph F. Goldberg, Roy H. Perlis, S. Nassir Ghaemi, Joseph R. Calabrese, Charles L. Bowden, Stephen Wisniewski, David J. Miklowitz, Gary S. Sachs, Michael E. Thase
Journal: American Journal of Psychiatry (2007)

Practice guidelines have advised against treating patients with antidepressants during bipolar mixed states or dysphoric manias. However, few studies have examined the outcomes of patients with co-occurring manic and depressive symptoms who are treated with antidepressants plus mood stabilizing drugs.The authors compared outcomes in patients with bipolar disorder who received a mood stabilizing agent with versus without an antidepressant for a bipolar depressive episode accompanied by > or = 2 concurrent manic symptoms. The 335 participants were drawn from the first 2,000 enrollees in the National Institute of Mental Health (NIMH) Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Kaplan-Meier survival curves and Cox regression models were used to compare time to recovery. General linear models examined the relationship between antidepressant use or mania symptom load at the study entry and mania or depression symptom severity at the 3-month follow-up.Adjunctive antidepressant use was associated with significantly higher mania symptom severity at the 3-month follow-up. The probability of recovery at 3 months was lower among patients with higher baseline depression severity. Antidepressant use neither hastened nor prolonged time to recovery once potential confounding factors were covaried in a Cox regression model.In bipolar depression accompanied by manic symptoms, antidepressants do not hasten time to recovery relative to treatment with mood stabilizers alone, and treatment with antidepressants may lead to greater manic symptom severity. These findings are consistent with those from the STEP-BD randomized trial for pure bipolar depression, in which adjunctive antidepressants did not yield higher recovery rates than did mood stabilizer monotherapy.
Poly(ethylene glycol)–paclitaxel–alendronate self-assembled micelles for the targeted treatment of breast cancer bone metastases
Authors: Keren Miller, Chiara Clementi, Dina Polyak, Anat Eldar-Boock, Liat Benayoun, Iris Barshack, Yuval Shaked, Gianfranco Pasut, Ronit Satchi-Fainaro
Journal: Biomaterials (2013)
Treating household drinking water with chlorine tablets does not prevent diarrhoea, study concludes
Authors: C. Travasso
Journal: BMJ (2013)

Using tablets to chlorinate household drinking water does not reduce the prevalence of diarrhoea in children, a study conducted in India has found.

Diarrhoeal diseases affect over 287 000 people each year in India. Some research has indicated that household water treatment and safe storage interventions, such as boiling, chlorinating, and filtering, can reduce the incidence of diarrhoea by 30-40%. As a result the World Health Organization and Unicef have recommended such an approach, particularly in populations that do not have access to safe water supplies. In India only 11% of people in rural areas have a household water supply.

However, a large double …
Upon contact with stimulated T cells, expression of peptidylarginine deiminase 2 and 4 is upregulated in human monocytes
Authors: S. Ferrari-Lacraz, M. Sebbag, R. Chicheportiche, C. Foulquier, G. Serre, J.-M. Dayer
Journal: Annals of the Rheumatic Diseases (2010)

Rheumatoid arthritis (RA) is characterised by the presence of autoantibodies to ‘citrullinated’ proteins, the citrullination of which is mediated by peptidylarginine deiminase (PAD). Among these enzymes, two PAD isotypes – PAD 2 and 4 – play a major role in RA pathogenesis. In RA, joints are infiltrated with inflammatory cells, mainly monocyte/macrophages and lymphocytes, and T cell contact-mediated activation of monocytes is known to result in secretion of …
TCT-752 Ecarin Clotting Time (ECT) more accurately reflects bivalirudin concentration than Activated Clotting Time (ACT) in patients undergoing Percutaneous Coronary Intervention using bivalirudin anticoagulation
Authors: Ronan Margey, Helen Ridgway, Richard Rullman, Jeff Spencer, Ronan Margey, Iris McNulty, Aditya Mangla, Sotir Polena, Daniel Soffer, Ik-Kyung Jang
Journal: Journal of the American College of Cardiology (2012)
Endoscopic Sphincterotomy in the Early Treatment of Acute Pancreatitis
Authors: Robin C.N. Williamson
Journal: New England Journal of Medicine (1993)

If the lodging of a gallstone at the duodenal papilla can precipitate an attack of acute pancreatitis, it is logical to suppose that the sooner the stone is removed the better the outcome will be. One of the first to explore this hypothesis was the Argentinian surgeon Acosta. Having found that the offending calculus could often be retrieved from the stool of a patient who recovered, Acosta and colleagues showed that urgent surgical (transduodenal) sphincterotomy reduced the mortality rate associated with acute pancreatitis from 16 percent to 2 percent1. This timely dislodging of an impacted stone might therefore prevent . . .
Complementary medicine. The practice of acupuncture needs tighter safeguards.
Authors: P Baldry
Journal: BMJ (1993)

numbers by making bids for staff grade posts and increasing the allocation of junior staff to medicine, all of which had been blocked by senior manage- ment.After my dismissal all the plans were imple- mented.The defendants apologised unreservedly to me and my family and stated that they wished publicly to vindicate fully my reputation both as a doctor and as a departmental manager.They agreed to pay my full costs and substantial damages.This case shows how vulnerable doctors can be in undertaking a significant management role and how the most senior managers can use their power to blame a doctor manager unjustifiably for their own inadequacies.The result also shows that, at present, consultants may have a more secure position in a trust than managers, whose short term rolling contracts may encourage them to scapegoat doctors to preserve their own position.
The Strange Allure of State “Right-to-Try” Laws
Authors: Patricia J. Zettler, Henry T. Greely
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Doctors in Iraq face amputation dilemma
Authors: C Court
Journal: BMJ (1994)

The introduction in Iraq of laws allowing amputation of the hand or foot as punishment for crime has led to waves of protest in the country and to fears by doctors that if they refuse to carry out the amputations they will be arrested. According to the international human rights pressure group Amnesty International, four people have been sentenced, of of whom two have had amputations, since the law was introduced. Amnesty says that, according to Decree No 59, passed by Saddam Hussein's Revolutionary Command …
Visual demonstration of hepatitis C virus-specific memory CD8+ T-cell expansion in patients with acute hepatitis C
Authors: Yuji Sobao, Hiroko Tomiyama, Saburo Nakamura, Hisahiko Sekihara, Katsuaki Tanaka, Masafumi Takiguchi
Journal: Hepatology (2001)

Hepatitis C virus (HCV)–specific CD8 + T cells in peripheral blood mononuclear cells (PBMCs) from patients infected with HCV were quantitatively analyzed by flow cytometry using an HLA–B*3501–HCV epitope tetrameric complex. In chronic hepatitis C, tetramer + CD8 + T cells were detected at frequencies ranging from 0.05% to 0.12% of total CD8 + T cells. The number of tetramer + CD8 + T cells in acute phase PBMCs from patients with acute hepatitis C was about 3 to 5 times higher than in recovery phase PBMCs from the same patients and in PBMCs from patients with chronic hepatitis C. Expanding tetramer + CD8 + T cells in PBMCs from patients with acute hepatitis C express a CD28 + CD45RA - memory T–cell phenotype. In contrast, tetramer + CD8 + T cells in PBMCs from patients with chronic hepatitis C did not predominantly express this phenotype. These tetramer + CD8 + T cells did not have perforin in their cytoplasma. The present study visually showed that a high number of circulating HCV–specific CD8 + T cells in acute phase PBMCs from patients with acute hepatitis C are mostly memory T cells.
Crescendo Angina Pectoris in a 28-Year-Old Man
Authors: Leland B. Housman
Journal: JAMA (1975)

AORTOCORONARY saphenous vein bypass grafting can relieve the symptoms of ischemic heart disease, but it has rarely been reported in very young patients.<sup>1</sup>A 28-year-old man with crescendo angina and no coronary artery disease risk factors recently underwent emergency coronary arteriography and double aortocoronary vein bypass grafting at the University of Oregon Medical School. To our knowledge, this is the youngest such patient reported in the literature. The presence of such advanced disease in so young a patient without the usual risk factors posed important therapeutic and prognostic problems. Although the long-term prognosis for this patient was and is uncertain, excellent immediate therapeutic results seemed readily attainable, and we considered the patient's youth to be a strong indication for aggressive surgical treatment.<sup>2</sup> Our criteria for the diagnosis of "unstable" angina have been defined in a recent report<sup>3</sup>and include chest pain at rest that persists more than 24
Bullous pemphigoid in association with cutaneous lesions specific to a myelodysplastic syndrome
Authors: P. MODIANO, S. REICHERT, A. BARBAUD, P. BERNARD, M. WEBER, J.L. SCHMUTZ
Journal: British Journal of Dermatology (1997)

Specific cutaneous lesions are a rare occurrence in myelodysplastic syndromes (MDS). The concurrent association of blistering skin lesions similar to those in bullous pemphigoid (BP), even though a rare event, suggests that BP may be a paraneoplastic syndrome. We report an 86-year-old man who had a refractory anaemia with excess bone marrow blasts in transformation, who developed a generalized pruritic blistering eruption. Immunohistopathological tests showed subepidermal blisters with linear deposits of IgG and C3 along the basement membrane zone of the epidermis surrounding a tumoral dermal infiltrate of CD13+ and CD15+ cells. Immunoblotting studies using epidermal extracts revealed circulating IgG antibodies against three protein bands: a 210-215 kDa band, a 180 kDa band which co-migrated with the BP 180 antigen, and a 190 kDa band. The tumour infiltrate may have revealed antigenic determinants which led to the onset of BP. The concept of paraneoplastic pemphigoid remains to be either confirmed or invalidated by further epidemiological studies.
Rodney Lloyd Herbert
Authors: D. Herbert
Journal: BMJ (2014)

Regulation of innate inflammatory responses against the enteric microbiota is essential for the maintenance of intestinal homeostasis. Key participants in innate defenses are macrophages. In these studies, the basic leucine zipper protein, NFIL3, is identified as a regulatory transcription factor in macrophages, controlling IL-12 p40 production induced by bacterial products and the enteric microbiota. Exposure to commensal bacteria and bacterial products induced NFIL3 in cultured macrophages and in vivo. The <i>Il12b</i> promoter has a putative DNA-binding element for NFIL3. Basal and LPS-activated NFIL3 binding to this site was confirmed by chromatin immunoprecipitation. LPS-induced <i>Il12b</i> promoter activity was inhibited by NFIL3 expression and augmented by NFIL3-short hairpin RNA in an <i>Il12b</i>-bacterial artificial chromosome-GFP reporter macrophage line. <i>Il12b</i> inhibition by NFIL3 does not require IL-10 expression, but a C-terminal minimal repression domain is necessary. Furthermore, colonic CD11b<sup>+</sup> lamina propria mononuclear cells from <i>Nfil3<sup>−/−</sup></i> mice spontaneously expressed <i>Il12b</i> mRNA. Importantly, lower expression of <i>NFIL3</i> was observed in CD14<sup>+</sup> lamina propria mononuclear cells from Crohn’s disease and ulcerative colitis patients compared with control subjects. Likewise, no induction of <i>Nfil3</i> was observed in colons of colitis-prone <i>Il10<sup>−/−</sup></i> mice transitioned from germ-free to a conventional microbiota. In conclusion, these experiments characterize NFIL3 as an <i>Il12b</i> transcriptional inhibitor. Interactions of macrophages with the enteric microbiota induce NFIL3 to limit their inflammatory capacity. Furthermore, altered intestinal NFIL3 expression may have implications for the pathogenesis of experimental and human inflammatory bowel diseases.
Opportunistic infection of chronic skin ulcers with Pseudomonas putrefaciens
Authors: P. C. APPELBAUM, ANNETTE J. BOWEN
Journal: British Journal of Dermatology (1978)

Heavy growth of Pseudomonas putrefaciens was isolated repeatedly in mixed culture with other Gram-negative rods from chronic ulcers on the extremities of an elderly patient with burnt-out leprosy. Treatment was with systemic cotrimoxazole, topical framycetin and general supportive therapy, and the ulcers gradually healed over a period of 4 weeks.
Intravascular brachytherapy for native coronary ostial in-stent restenotic lesions
Authors: Costantino O Costantini, Alexandra J Lansky, Gary S Mintz, Kazuyuki Shirai, George Dangas, Roxana Mehran, Martin Fahy, Steven Slack, Maria Coral, Paul S Teirstein, Ron Waksman, Gregg Stone, Jeffrey Moses, Martin B Leon
Journal: Journal of the American College of Cardiology (2003)
1140-168 In vivo caspase-inhibition prevents plaque progression by reducing apoptosis and tissue-factor expression in a mouse model of chronic atherosclerosis
Authors: Randolph Hutter, Carolina Valdiviezo, Gurusher Panjrath, Bernhard Sauter, Francine Carrick, Valentin Fuster, Juan Jose Badimon
Journal: Journal of the American College of Cardiology (2004)
Dexamethasone for Alcohol Withdrawal
Authors: Stanislas Pol, Bertrand Nalpas, Pierre Berthelot
Journal: Annals of Internal Medicine (1991)

Letters15 April 1991Dexamethasone for Alcohol WithdrawalStanislas Pol, MD, Bertrand Nalpas, MD, PhD, Pierre Berthelot, MDStanislas Pol, MDSearch for more papers by this author, Bertrand Nalpas, MD, PhDSearch for more papers by this author, Pierre Berthelot, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-8-705 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editors: The alcohol withdrawal syndrome (AWS) is related to an increase in sympathetic nervous system activity and to a reduction in the threshold of neuronal excitability. Patients undergoing alcohol withdrawal require pharmacologic treatment because of the risk, possibly lethal, of delirium tremens. Pharmacologic treatment (usually based on neuroleptic, sedative, or anxiolytic drugs) is problematic in patients with hepatocellular failure, in whom iatrogenic encephalopathy may increase morbidity or mortality, and in patients with AWS that is resistant to psychoactive drugs.Dexamethasone has been shown to be efficacious in the treatment of patients with delirium tremens, (1), and was especially...References1. Flink E, Lizarralde G, and Jacobs W. Therapy of delirium tremens with urea (or dexamethasone) and magnesium sulfate. J Lab Clin Med. 1971;78:990. MedlineGoogle Scholar2. Fisher D, Simpson R, Smith K, and Mattox K. Efficacy of dexamethasone in benzodiazepine-resistant delirium tremens. Lancet. 1988:1340-1341. Google Scholar3. Cushman P, Forbes R, Lerner W, and Stewart M. Alcohol withdrawal syndromes: clinical management with loxidine. Alcohol Clin Exp Res. 1985;9:103-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Stanislas Pol, MD; Bertrand Nalpas, MD, PhD; Pierre Berthelot, MDAffiliations: Hôpital Laënnec 75340 Paris France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAlcohol and Drug AbuseAlcohol withdrawal as an underrated cause of agitated delirium and terminal restlessness in patients with advanced malignancyPlace de la corticothérapie brève dans les affections non malignesAlkylation of salts ofN-(β-hydroxyalkyl)-N′-hydroxydiazeneN-oxides with alkyl halides and dimethyl sulfateAlcohol Intoxication and WithdrawalDexamethasone in the Treatment of the Alcohol Withdrawal SyndromePharmacotherapies for Alcohol Problems: A Review of Research with Focus on Developments since 1991Basal serum cortisol and dexamethasone-induced growth hormone release in the alcohol dependence syndromeStructure–Property Relationships in Perfluoropolyethers: A Family of Polymeric Oils 15 April 1991Volume 114, Issue 8Page: 705-706KeywordsAlcoholsAntipsychoticsAnxiolyticsDelirium tremensDrugsMorbidityMortalityPatientsSedativesSympathetic nervous system ePublished: 1 December 2008 Issue Published: 15 April 1991 PDF downloadLoading ...
Pediatric patients with eosinophilic esophagitis have a high prevalence of IgE sensitization to multiple food antigens
Authors: A.H. Assa'ad, P.E. Putman, J.R. Guajardo, A. Mishra, R.J. Noel, M.H. Collins, S.C. Jameson, M.E. Rothenberg
Journal: Journal of Allergy and Clinical Immunology (2003)
Generation of natural killer cells: an autonomous function of the bone marrow.
Authors: O Haller, R Kiessling, A Orn, H Wigzell
Journal: The Journal of Experimental Medicine (1977)

Generation of natural killer (NK) cells in spleens from radiation chimeras produced between pairs of histocompatible 'high' and 'low' NK-reactive mouse strains has been investigated. Spleen cells of high-reactive recipients reconstituted with bone marrow from low-reactive mice were found to be low reactive. Conversely, spleen cells of low mice grafted with bone marrow or fetal liver cells from high donors were high reactive. Similarly, the age-related changes of NK activity were shown to be expressed at the bone marrow precursor cell level. These results indicate that the generation of natural killer cells is an inborn and autonomous function of the bone marrow and does not depend on the genotype or other influences of the host environment.
Aberrant Notch1-dependent effects on glomerular parietal epithelial cells promotes collapsing focal segmental glomerulosclerosis with progressive podocyte loss
Authors: Toshiharu Ueno, Namiko Kobayashi, Makiko Nakayama, Yasutoshi Takashima, Takamoto Ohse, Ira Pastan, Jeffrey W. Pippin, Stuart J. Shankland, Noriko Uesugi, Taiji Matsusaka, Michio Nagata
Journal: Kidney International (2013)