Infarction of Bone Marrow in the Sickle Cell Disorders
Authors: SAMUEL CHARACHE
Journal: Annals of Internal Medicine (1967)

Article1 December 1967Infarction of Bone Marrow in the Sickle Cell DisordersSAMUEL CHARACHE, M.D., DAVID L. PAGE, M.D.SAMUEL CHARACHE, M.D.Search for more papers by this author, DAVID L. PAGE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-6-1195 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPainful crises in the sickle cell disorders may be produced by capillary stasis, venous thrombosis, or arterial emboli (1). The latter may be caused by escape of aggregated sickled cells from dilated capillaries or venules or by particles of fat or bone marrow that are believed to arise from areas of medullary bone infarction. Bone marrow infarction has been described at autopsy in many reports of patients with the sickle cell disorders (2-5). Ample clinical and roentgenologic evidence suggests that similar changes occur in patients who survive episodes of pain, but that suggestion has not been documented in reported cases...References1. DIGGS LW: Sickle cell crises. Amer. J. Clin. Path. 44: 1, 1965. CrossrefGoogle Scholar2. DIGGSPULLIAMKING LWHNJC: The bone changes in sickle cell anemia. Southern Med. J. 30: 249, 1937. CrossrefGoogle Scholar3. SHELLEYCURTIS WMEM: Bone marrow and fat embolism in sickle cell anemia and sickle cell hemoglobin C disease. Bull. Hopkins Hosp. 103: 8, 1958. MedlineGoogle Scholar4. RYWLINBLOCKWERNER AMALCS: Hemoglobin C and S disease in pregnancy. Report of a case with bone marrow and fat emboli. Amer. J. Obstet. Gynec. 86: 1055, 1963. CrossrefMedlineGoogle Scholar5. OBERBRUNOSIMONWEINER WBMSRML: Hemoglobin S-C disease with fat embolism; report of a patient dying in crisis; autopsy findings. Amer. J. Med. 27: 647, 1959. CrossrefMedlineGoogle Scholar6. 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TANAKACLIFFORDAXELROD KRGOAR: Sickle cell anemia (homozygous S) with aseptic necrosis of femoral head. Blood 11: 998, 1956. CrossrefMedlineGoogle Scholar14. MOSELEY JE: Patterns of bone change in the sickle cell states. J. Mount Sinai Hosp. NY 26: 424, 1959. MedlineGoogle Scholar15. WYATTORRAHOOD JPMD: Massive fat embolism following marrow infarction in sickle cell anemia. Arch. Path. (Chicago) 53: 233, 1952. MedlineGoogle Scholar16. REYNOLDS J: Roentgenographic and clinical appraisal of sickle cell-hemoglobin C disease. Amer. J. Roentgen. 88: 512, 1962. Google Scholar17. EVANSSYMMES PVAT: Bone marrow infarction with fat embolism and nephrosis in sickle cell disease. J. Indiana Med. Ass. 50: 1101, 1957. Google Scholar18. WERTHAMMITCHELLANGRIST FNA: The brain in sickle cell anemia. Arch. Neurol. (Chicago) 47: 752, 1942. CrossrefGoogle Scholar19. VANCEFISHER BMRC: Sickle cell disease. Two cases, one presenting fat embolism as a fatal complication. Arch. Path. (Chicago) 32: 378, 1941. Google Scholar20. CHARACHECONLEY SCL: Rate of sickling of red cells during deoxygenation of blood from persons with various sickling disorders. Blood 24: 25, 1964. CrossrefMedlineGoogle Scholar21. RUCKNAGELNEEL DLJV: The hemoglobinopathies. Progr. Med. Genet. 1: 158, 1961. Google Scholar22. WELCHGOLDBERG RBMF: Sickle-cell hemoglobin and its relation to fundus abnormality. Arch. Ophthal. (Chicago) 75: 353, 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, MarylandFrom the Departments of Medicine and Pathology, The Johns Hopkins University and Hospital, Baltimore, Md.This study was supported in part by grant FR-35, Clinical Research Center, U. S. Public Health Service, Washington, D. C., research grant HE-02799, National Heart Institute, and graduate training grant T1-AM-5260, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Samuel Charache, M.D., 1006 Blalock Bldg., The Johns Hopkins Hospital, Baltimore, Md. 21205. 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PORTNOY, M.D., JOHN C. HERION, M.D.ReferenceInherited disorders of hemoglobin synthesis and pregnancyPolymerization through the carbon-sulfur double bond 1 December 1967Volume 67, Issue 6Page: 1195-1200KeywordsBone marrowBone marrow cellsCapillariesHospital medicineInfarctionMetabolic disordersResearch grantsSickle cell diseaseThrombosisVenules Issue Published: 1 December 1967 PDF downloadLoading ...