Aspirin, Dipyridamole, and Thrombotic Thrombocytopenic Purpura
Authors: LEO R. ZACHARSKI
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 May 1982Aspirin, Dipyridamole, and Thrombotic Thrombocytopenic PurpuraLEO R. ZACHARSKI, M.D.LEO R. ZACHARSKI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-5-679 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The judgment as to what constitutes the best treatment for patients with thrombotic thrombocytopenic purpura (TTP) is based on empiric evidence rather than on the results of controlled therapeutic trials. Unfortunately, TTP does not lend itself to such trials because of its rarity and rapidly fatal course, and because commonly accepted treatments are relatively innocuous. Attempts to evaluate the efficacy of specific forms of treatment have been frustrated because multiple treatments are usually used in individual patients, intermediate measures of responses such as changes in clinical or laboratory variables are not always a reliable guide to survival,...References1. KENNEDYZACHARSKIBECK SLJ. Thrombotic thrombocytopenic purpura: analysis of 48 unselected cases. Semin Thromb Hemostas. 1980;6:341-9. CrossrefMedlineGoogle Scholar2. ROSOVEHOGOLDFINGER MWD. Ineffectiveness of aspirin and dipyridamole in the treatment of thrombotic thrombocytopenic purpura. Ann Intern Med. 1982;96:27-33. LinkGoogle Scholar1. ROSOVEWOGOLDFINGER MWD. Ineffectiveness of aspirin and dipyridamole in the treatment of thrombotic thrombocytopenic purpura. Ann Intern Med. 1982;96:27-33. LinkGoogle Scholar2. MYERS T. Treatment of thrombotic thrombocytopenic purpura with combined exchange plasmapheresis and antiplatelet agents. Semin Thromb Hemostas. 1981;7:37-42. CrossrefMedlineGoogle Scholar3. MYERSWAKEMBALLTREMONT TCES. Thrombotic thrombocytopenic purpura: combined treatments with plasmapheresis and antiplatelet agents. Ann Intern Med. 1980;92:949-55. LinkGoogle Scholar4. AMOROSIKARPATKIN ES. Antiplatelet treatment of thrombotic thrombocytopenic purpura. Ann Intern Med. 1977;86:102-8. LinkGoogle Scholar1. ROSOVEHOGOLDFINGER MWD. Ineffectiveness of aspirin and dipyridamole in the treatment of thrombotic thrombocytopenic purpura. Ann Intern Med. 1982;96:27-33. LinkGoogle Scholar2. MOSCHCOWITZ E. An acute febrile pleiochromic anemia with hyaline thrombosis of the terminal arterioles and capillaries: an undescribed disease. Arch Intern Med. 1925;36:89-93. CrossrefGoogle Scholar1. NEAME P. Immunologic and other factors in thrombotic thrombocytopenic purpura (TTP). Semin Thromb Hemostas. 1980;6:416-29. CrossrefMedlineGoogle Scholar1. ROSOVEHOGOLDFINGER MWD. Ineffectiveness of aspirin and dipyridamole in the treatment of thrombotic thrombocytopenic purpura. Ann Intern Med. 1982;96:27-33. LinkGoogle Scholar2. O'BRIEN J. Effects of salicylates on human platelets. Lancet. 1968;1:779-80. CrossrefMedlineGoogle Scholar3. BURCHSTANFORDMAJERUS JNP. Inhibition of platelet prostaglandin synthetase by oral aspirin. J Clin Invest. 1978;61:314-9. CrossrefMedlineGoogle Scholar4. MASOTTIPOGGESIGALANTI GLG. Differential inhibition of prostacyclin production and platelet aggregation by aspirin. Lancet. 1979;2:1213-6. CrossrefMedlineGoogle Scholar1. ROSOVEHOGOLDFINGER MWD. Ineffectiveness of aspirin and dipyridamole in the treatment of thrombotic thrombocytopenic purpura. Ann Intern Med. 1982;96:27-33. LinkGoogle Scholar2. RAJAHPENNYCROWPEPPERWATSON SAMMD. The interaction of varying doses of dipyridamole and acetyl salicylic acid on the inhibition of platelet functions and their effect on bleeding time. Br J Clin Pharmacol. 1979;8;483-9. CrossrefMedlineGoogle Scholar3. LORENZSIESSWEBER MWP. Effects of very low versus standard dose acetyl salicyclic acid, dipyridamole and sulfinpyrazone on platelet function and thromboxane formation in man. Eur J Pharmacol. 1981:70:511-8. CrossrefMedlineGoogle Scholar4. HARKERSLIGHTER LS. Studies of platelet and fibrinogen kinetics in patients with prosthetic heart valves. N Engl J Med. 1970;283:1302-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThrombotic Thrombocytopenic PurpuraMoschcowitz Revisited 1 May 1982Volume 96, Issue 5Page: 679-681KeywordsAspirinClinical laboratoriesPatientsResearch laboratoriesThrombotic thrombocytopenic purpura Issue Published: 1 May 1982 PDF downloadLoading ...