tbuckley/cabot-search huggingface dataset:
Effective CpG Immunotherapy of Breast Carcinoma Prevents but Fails to Eradicate Established Brain Metastasis
Authors: Zhengming Xiong, Soheila Gharagozlou, Isabelita Vengco, Wei Chen, John R. Ohlfest
Journal: Clinical Cancer Research (2008)

Abstract Purpose: Breast cancer patients with brain metastasis have a dismal prognosis. We determined the ability of immunostimulatory CpG oligodeoxynucleotides (ODN) to treat or prevent brain metastasis in a mouse model. Experimental Design: Mice bearing orthotopic breast carcinoma with or without concurrent i.c. tumors were treated by injections of CpG ODN at the primary tumor. Immunologic memory was tested by tumor rechallenge and immune responses were assessed by flow cytometry, delayed-type hypersensitivity, and CTL assays. Results: Orthotopic tumors regressed in treated mice regardless of whether concurrent i.c. disease was present. In mice bearing only orthotopic tumors, CpG ODN rendered 50% tumor-free and they rejected tumor rechallenge in breast and brain. In mice with concurrent i.c. disease, there was no difference in brain tumor growth compared with saline controls, despite regression of the primary tumor. Flow cytometry revealed that treated mice that died from i.c. disease exhibited a significant increase in brain-infiltrating T and natural killer cells relative to saline controls. CTLs from these mice were able to kill tumor in vitro and extend survival of naive mice bearing less-established brain tumors by adoptive transfer. Conclusions: The lack of survival benefit in mice with appreciable brain metastasis was not explained by a deficit in lymphocyte trafficking or function because CTLs from these mice killed tumor and inhibited microscopic brain metastasis by adoptive transfer. These results indicate that CpG ODN might be beneficial as a preventative adjuvant to initial therapy preceding brain metastasis or to inhibit progression of microscopic brain metastases.
Normal Uptake of F-18 FDG in the Sublingual Gland
Authors: Trond Velde Bogsrud, Dimitris Karantanis, Val J. Lowe
Journal: Clinical Nuclear Medicine (2005)

A symmetric inverted “V” pattern of high uptake in the floor of the mouth is a consistent normal finding on F-18 FDG PET. There is no general agreement on the nature of this highly FDG-avid structure. Mylohyoid muscle, insertion site of the genioglossus muscle, other intrinsic tongue muscles, and the sublingual gland have been suggested. I-123 SPECT and F-18 FDG PET scans were performed on the same day in a patient with papillary thyroid carcinoma. Both the I-123 SPECT and F-18 FDG PET showed the same inverted “V” pattern in the floor of the mouth, corresponding to the sublingual gland typically seen on magnetic resonance imaging.
Gonococcal Osteomyelitis Complicating Septic Arthritis
Authors: Elizabeth A. Tindall
Journal: JAMA (1983)

GONOCOCCAL arthritis is common and well described.<sup>1</sup>It is easily treated with antibiotics and usually has no serious sequelae. While nongonococcal septic arthritis frequently is associated with osteomyelitis, gonococcal osteomyelitis is rare. We report a case of gonococcal osteomyelitis in a young man that resulted in permanent disability. <h3>Report of a Case</h3> A 29-year-old man had a sudden onset of right shoulder pain associated with a temperature of 39 °C and malaise. On day 8 of his illness, his joint findings were reported to be normal. His sedimentation rate was 52 mm/hr (Westergren). Despite therapy with phenylbutazone (Butazolidin), migratory arthralgias developed, involving his wrists, ankles, hips, and shoulder, with red, tender swelling of his left wrist and right ankle. The patient was hospitalized on day 10 with persistent joint complaints. Physical examination disclosed limited abduction of his right shoulder, tender ankles and left wrist, and pain on motion of
Myocardial function and hemoglobin oxygen affinity during hyperglycemia in the fetal lamb.
Authors: H Bard, J C Fouron, X De Muylder, G Ducharme, J S Lafond
Journal: Journal of Clinical Investigation (1986)

To determine the effects of maternal hyperglycemia on fetal hemodynamic and cardiac function, a study was carried out on nine chronically catheterized fetal sheep. In six fetuses, glucose was infused intravenously with an initial dose of 5 mg/kg per min. Data were compared with controls. This dose was gradually increased to 16 mg/kg per min by the fifth day. The initial blood glucose was 14.7 +/- 3.0 mg/dl and increased to 54.6 +/- 16.4 mg/dl by the last day of the infusion period (P less than 0.001). The PO2 decreased from a baseline of 20.25 +/- 3.40 to 15.88 +/- 5.24 mmHg (P less than 0.01). Similarly significant decreases were also observed for the blood O2 content and O2 hemoglobin saturation: 8.5 +/- 1.7 to 6.4 +/- 2.2 ml/dl and 62.3 +/- 13.6 to 46.1 +/- 17.6%, respectively, during hyperglycemia (P less than 0.01). The duration of the preejection period (PEP) before the start of the experiment was 45 +/- 4 ms; a final value of 57 +/- 10 ms was obtained (P less than 0.01). However, the electromechanical delay and ejection time (ET) showed no significant variation. The ratio of the PEP/ET increased from 0.31 +/- 0.04 to 0.38 +/- 0.07 (P less than 0.01) during hyperglycemia. The reticulocytes increased from 1.4 +/- 1.8 to 3.1 +/- 2.9% (P less than 0.05) and the 2,3-diphosphoglycerate decreased from 4.4 +/- 1.1 to 2.8 +/- 1.2 mumol/g hemoglobin (P less than 0.005). This study demonstrated that fetal hyperglycemia depresses myocardial function in the fetal lamb. The changes in cardiac function could not be explained by the small drop in O2 saturation.
A means of speaking for patients with cuffed tracheostomy tubes.
Authors: R. M. Whitlock
Journal: BMJ (1967)

Clinicopathological Conferenceftnm-547 necropsy a characteristic finding is disease of small blood vessels of the sort we've seen in the patient we are now discussing.Why the red cells are destroyed is really anybody's guess, but one hypothesis is that they are destroyed in some way by contact with the damaged vessels.Whether this is a result of contact with necrotic tissue, or as the result of intimate contact with fibrin deposited in the vessels, we don't know.
Maximum Treadmill Exercise Test in Patients with Abnormal Control Electrocardiograms
Authors: JOSEPH W. LINHART, HOWARD B. TURNOFF
Journal: Circulation (1974)

To determine the validity and safety of exercise induced ST changes (1 mm ischemic depression or further depression in ECG lead V 5 ) as an indication of coronary artery disease (CAD) in patients with abnormal control electrocardiograms (ECG), 121 such patients were compared to 57 patients with a normal control ECG. All underwent a maximum graded treadmill exercise test and coronary arteriography. Among those patients with normal control ECGs, there were no false positives and five false negatives (sensitivity-85%, specificity-100%). In 61 patients with abnormal ECG (no drug therapy except nitrates) there were four false positives and nine false negatives (sensitivity-76%, specificity-79%). In this group of patients T waves reverted from negative to positive in four patients with CAD and 10 patients with no CAD, but T inversion during exercise only occurred in those with CAD (6 patients). Three of 12 patients (25%) with ECG evidence of old infarction and four of eight with single vessel disease had false negative tests. In 60 patients with abnormal ECG on drug therapy there were 10 false positives (17%) and 15 false negatives (sensitivity-55%, specificity-63%). Not helpful in differentiation were resting T vs ST changes, induction of arrhythmias or exercise induced chest pain. The validity of exercise induced ST changes in differentiating CAD is excellent when the control ECG is normal and is only slightly reduced with control ST-T wave abnormalities. When the latter occur in association with cardiovascular drug therapy, other than nitrates, the exercise ECG is of no use in differential diagnosis although still valid and safe for the determination of exercise tolerance.
Accelerated Junctional Escape
Authors: SUZANNE B. KNOEBEL, CHARLES FISCH
Journal: Circulation (1974)

During the routine interpretation of electrocardiograms, 49 cases of spontaneously occurring accelerated, or borderline accelerated, junctional escape complexes (escape intervals of 1200 ± 20 msec) were encountered. Forty-seven of the 49 patients whose cardiograms demonstrated the accelerated junctional escapes had the clinical setting recognized to be associated with the more protracted accelerated junctional rhythm, nonparoxysmal junctional tachycardia. In addition, five patients demonstrated nonparoxysmal junctional tachycardia immediately preceding or subsequent to the cardiograms demonstrating accelerated junctional escape. It is suggested, therefore, that the two arrhythmias, i.e., accelerated junctional escape and nonparoxysmal junctional tachycardia, may be of similar clinical significance. The determinants of the length of the manifest escape interval could be assessed in those cases where two or more junctional escape complexes occurred in sequence, allowing the true interectopic interval to be ascertained. The dominant role of the rate of atrioventricular conduction and the sequence of ventricular and junctional activation in determining the length of the manifest escape interval was apparent.
Occurrence of angiosarcoma and gastric adenocarcinoma following a cutaneous CD30-positive anaplastic large cell lymphoma
Authors: S.K. Kang, S.E. Chang, J.H. Choi, K.J. Sung, K.C. Moon, J.K. Koh, J.R. Huh
Journal: British Journal of Dermatology (2002)

Journal Article Occurrence of angiosarcoma and gastric adenocarcinoma following a cutaneous CD30‐positive anaplastic large cell lymphoma Get access S.K. Kang, S.K. Kang Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar S.E. Chang, S.E. Chang Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar J.H. Choi, J.H. Choi Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar K.J. Sung, K.J. Sung Departments of Dermatology and Correspondence: Dr K.J. Sung E‐mail: derm@www.amc.seoul.kr derm@www.amc.seoul.kr Search for other works by this author on: Oxford Academic Google Scholar K.C. Moon, K.C. Moon Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar J.K. Koh, J.K. Koh Pathology, Asan Medical Center, College of Medicine, University of Ulsan, 388–1, Poognap‐dong, Songpa‐gu, Seoul, 138–736 South Korea Search for other works by this author on: Oxford Academic Google Scholar J.R. Huh J.R. Huh Pathology, Asan Medical Center, College of Medicine, University of Ulsan, 388–1, Poognap‐dong, Songpa‐gu, Seoul, 138–736 South Korea Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 147, Issue 4, 1 October 2002, Pages 818–820, https://doi.org/10.1046/j.1365-2133.2002.49288.x Published: 01 October 2002
THE STUDY OF LEAD POISONING IN AN ENAMELING PLANT
Authors: W. S. LEATHERS
Journal: JAMA (1927)

In a study of the health problems of Nashville during the past year, a survey was made of the industries of the community employing a hundred or more men, from the standpoint of the medical service and hygienic measures provided for the care and protection of the health of employees. As many as thirty-five industrial and commercial establishments were investigated. Hazardous processes involving the use of dangerous substances were noted in four of these places; in three, the protection by enclosure and exhaust ventilation appeared to be adequate, while in one of the places examined the method of handling the process was not satisfactory. After the study had been made, a workman from the factory which was pronounced as having a possible industrial hazard reported, October 23, to a local hospital for examination. The hospital record of the case revealed that the patient's condition had been diagnosed as peptic ulcer.
Are there environmental forms of systemic autoimmune diseases?
Authors: E V Hess
Journal: Environmental Health Perspectives (1999)

A large number of drugs and an increasing number of environmental agents reportedly result in the appearance of a number of autoantibodies and in many instances in the appearance of a range of autoimmune clinical syndromes. The major disorders so recognized have marked resemblances to the autoimmune disease systemic lupus erythematosus. The commonly used term is drug-induced lupus; a better term is drug-related lupus. There is considerable interest at the present time in an increasing number of environmental agents. There have been two epidemics in recent years--one in Spain to a contaminant of rapeseed oil and one in the United States to a contaminant of l-tryptophan that caused an eosinophilic myositis. It is important for physicians and others involved in health care to recognize the potential associations of these diseases of unknown cause or causes.
Impaired redox status and cytochrome c oxidase deficiency in patients with polymyalgia rheumatica
Authors: P Chariot
Journal: Annals of the Rheumatic Diseases (2001)

<h3>OBJECTIVE</h3> To evaluate redox status and muscular mitochondrial abnormalities in patients with polymyalgia rheumatica (PMR). <h3>METHODS</h3> Prospective evaluation of deltoid muscle biopsy in 15 patients with PMR. Fifteen subjects matched for age and sex, with histologically normal muscle and without clinical evidence of myopathy, were used as controls. Cryostat sections of muscle were processed for conventional dyes, cytochrome<i>c</i> oxidase (COX), usual histochemical reactions, and Sudan black. A total of 300–800 fibres was examined in each case. Blood lactate, pyruvate, and lactate/pyruvate ratio were determined in all patients. <h3>RESULTS</h3> Ragged red fibres were found in eight patients with PMR and accounted for 0–0.5% of fibres. Focal COX deficiency was found in 14 (93%) of 15 patients and in nine (60%) of 15 controls. COX deficient fibres were more common in patients with PMR (range 0–2.5%; mean 0.9%) than in controls (range 0–1.2%; mean 0.3%) (paired<i>t</i> test, p=0.001). Seven (47%) of 15 patients had high blood lactate levels (1.50–2.60 mmol/l) or high blood lactate/pyruvate ratios (22–25). <h3>CONCLUSIONS</h3> PMR is associated with mitochondrial abnormalities not solely related to the aging process.
Selection of Unrelated Compatible Platelet Donors by Lymphocyte HL-A Matching
Authors: Ronald A. Yankee, Kenneth S. Graff, Regina Dowling, Edward S. Henderson
Journal: New England Journal of Medicine (1973)

Thrombocytopenic patients who are refractory to transfusions of platelets obtained from random donors will respond to platelets from HL-A-identical siblings. The efficacy of using HL-A lymphocyte typing to select unrelated compatible platelet donors, however, has not been well documented. In this study, three patients who were not responding to random donor platelets were transfused with platelets obtained from selected unrelated persons matched for HL-A. The median response in circulating platelets (increment times body-surface area per unit) measured at 20 hours was 11.2, 9.1 and 17.0 (X 103) as compared to 0, 0 and 2.2 (X 103), respectively, to nonmatched platelets. These observations indicate that alloimmunization in multi-transfused patients is primarily due to HL-A antigens and that lymphocyte HL-A typing can be used to select unrelated compatible platelet donors for refractory patients.
SYPHILITIC DESTRUCTION OF THE SCALP
Authors: D. E. H. CLEVELAND
Journal: British Journal of Dermatology (1933)

Journal Article SYPHILITIC DESTRUCTION OF THE SCALP Get access D. E. H. CLEVELAND, M.D., C.M. D. E. H. CLEVELAND, M.D., C.M. Vancouver, B.C Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 45, Issue 5, 1 May 1933, Pages 187–190, https://doi.org/10.1111/j.1365-2133.1933.tb12416.x Published: 01 May 1933
Reserpine in Psychosomatic Practice and Research
Authors: Ferruccio Antonelli
Journal: Psychotherapy and Psychosomatics (1956)

Research Articles| February 10 2010 Reserpine in Psychosomatic Practice and Research Subject Area: Psychiatry and Psychology Ferruccio Antonelli Ferruccio Antonelli Rome Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1956) 4 (4): 346–351. https://doi.org/10.1159/000285262 Article history Published Online: February 10 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Ferruccio Antonelli; Reserpine in Psychosomatic Practice and Research. Acta Psychotherapeutica et Psychosomatica 1 April 1956; 4 (4): 346–351. https://doi.org/10.1159/000285262 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1956Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Measurement of clinical change in progressive systemic sclerosis: a 1 year double-blind placebo-controlled trial of N-acetylcysteine.
Authors: D E Furst, P J Clements, R Harris, M Ross, J Levy, H E Paulus
Journal: Annals of the Rheumatic Diseases (1979)

N-acetylcysteine was employed as a therapeutic agent in a 1-year, parallel, double-blind, placebo-controlled, prospective study of 22 patients with progressive systemic sclerosis (PSS). Patients were closely followed-up and were extensively evaluated at baseline, 6 and 12 months. Most parameters remained unchanged during 1 year of study in both the NAC and placebo groups, which showed the need for prolonged studies of drugs in PSS if definitive results are to be obtained. Over the year of the study the diffusing capacity decreased in both groups, while several other parameters measured both increased and decreased. Several simple measures of function and skin distensibility were tested and two (oral aperature and handspread) were reproducible and sensitive enough to measure moderate changes of disease activity. They may be useful in future trials of drug effect in PSS.
Cofactor levels of mono‐ and diamine oxidase in atopic eczema
Authors: G. Ionescu, R. Kiehl
Journal: Allergy (1989)

We have recently shown that increased plasma histamine levels were associated with significantly lowered diamine and type B monoamine oxidase activities in platelet rich plasma of atopic eczema patients. We now report almost normal cofactor (pyridoxal phosphate and Cu 2+ ) levels for diamine oxidase but lowered cofactor (flavin adenine dinucleotide and Fe 2+ ) levels for type B monoamine oxidase.
Issues in Human Experimentation
Authors: ROBERT S. GORDON
Journal: Annals of Internal Medicine (1978)

The current status of two difficult and controversial issues—confidentiality of preliminary results of clinical studies and compensation for research-related injuries—is outlined. The principle of not publicizing results of clinical research until enough data have been accumulated to give statistically valid support for conclusions is in conflict with the principle of ready availability to the public of results of government-conducted and government-sponsored research. New legislation may be required to resolve the problem. The lack of a mechanism to compensate research subjects for unanticipated injuries that are not the result of negligence is a barrier to obtaining truly informed consent. A plan for overcoming this problem through Department of Health, Education, and Welfare regulations has been proposed and awaits implementation.
Neomycin Absorption in Man
Authors: Kerry J. Breen, Richard E. Bryant, Joel D. Levinson, Steven Schenker
Journal: Annals of Internal Medicine (1972)

This study compares absorption of 2.0 g of neomycin sulfate administered orally and by enema and assesses the influence of intestinal ulceration on absorption of neomycin. Absorption after enema, as measured by urinary excretion of neomycin over 48 hours and by sequential serum neomycin concentrations, was similar to that seen after oral administration in normal subjects, patients with liver disease, and patients with upper gastrointestinal ulcerations. Increasing enema retention times did not increase neomycin absorption. Patients with active peptic ulcers or regional enteritis did not absorb excessive amounts of orally administered neomycin. Patients with active uncomplicated ulcerative colitis did not have enhanced absorption of rectally administered neomycin. In all groups of subjects studied, bacteriocidal urinary neomycin concentrations were encountered with surprising frequency. We conclude that enema-administered neomycin is absorbed to the same extent as that administered orally and that intestinal ulceration does not enhance neomycin absorption.
Reducing the strain of dermatological surgery
Authors: R. Urwin, W. Hussain
Journal: British Journal of Dermatology (2014)

Journal Article Reducing the strain of dermatological surgery Get access R. Urwin, R. Urwin Dermatology Surgical & Laser Unit (C4) Leeds Centre for Dermatology Chapel Allerton Hospital Leeds LS7 4SA U.K Search for other works by this author on: Oxford Academic Google Scholar W. Hussain W. Hussain Dermatology Surgical & Laser Unit (C4) Leeds Centre for Dermatology Chapel Allerton Hospital Leeds LS7 4SA U.K Correspondence: W. Hussain. E‐mail: dr_w_hussain@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 2, 1 February 2015, Pages 546–547, https://doi.org/10.1111/bjd.13212 Published: 01 February 2015
PROLONGED DUAL ANTIPLATELET THERAPY FOLLOWING DRUG-ELUTING STENT IMPLANTATION: MORE BLEEDING AND NO REDUCTION IN ISCHEMIC EVENTS- A META-ANALYSIS OF CLINICAL TRIALS
Authors: Georges El-Hayek, Alexandre Benjo, Daniel Garcia, Mun Hong, Eyal Herzog, Jacqueline Tamis-Holland
Journal: Journal of the American College of Cardiology (2014)