tbuckley/cabot-search huggingface dataset:
Cost Implications of the Use of Ramipril in High-Risk Patients Based on the Heart Outcomes Prevention Evaluation (HOPE) Study
Authors: Andre Lamy, Salim Yusuf, Janice Pogue, Amiram Gafni
Journal: Circulation (2003)

Background— The HOPE study has demonstrated that ramipril is beneficial (ie, prevents cardiovascular death, myocardial infarction, and stroke) for a broad range of patients without evidence of left ventricular dysfunction or heart failure who are at high risk for cardiovascular event. In this study, we report the cost implications, in both the United States and Canada, of the use of ramipril after the HOPE study. Methods and Results— A third-party perspective was chosen (Medicare for the United States and Ministry of Health for Canada). We calculated the costs of the management strategies of ramipril and placebo. An annual discount rate of 3% was used over the 4.5 years of follow-up. Sensitivity analyses were performed. Costs are reported in United States dollars and in Canadian dollars, respectively. The total costs per patient (including acquisition costs of ramipril) were not different between the groups in both countries (United States, $13 520 versus $13 631; Canada, $8702 versus $8588). From the distribution of cases in the bootstrap analysis, we found that 90% of cases fall either into a cost-neutral or cost-saving situation (64% in United States and 27% in Canada) or into a cost-effectiveness situation with an incremental cost-effectiveness ratio &lt;$10 000 (in respective currency) per primary event saved. Conclusions— On the basis of these results, we suggest that the use of ramipril is likely to represent an efficient use of resources in both countries. These findings support the use of ramipril in populations included in the HOPE study.
Report to the Secretary of HEW From the Medical Advisory Group on Cyclamates
Authors: Roger O. Egeberg
Journal: JAMA (1970)

The Medical Advisory Group on Cyclamates appointed by Secretary Finch met on Nov 17 and 18, 1969, with representatives of the Food and Drug Administration and the National Institutes of Health to review the currently available data on the possible harmful effects of these nonnutritive sweeteners in relation to their potential benefits. The group considered the data on carcinogenic, mutagenic, teratogenic, enzymatic, osmotic, and growth effects of cyclamates and on their possible adverse influence in interaction with other drugs. After carefully reviewing the evidence currently available, the Medical Advisory Group on Cyclamates unanimously supported the secretary's prohibition of the inclusion of cyclamates in beverages for general use, and in the future processing of general purpose foods and vegetables. It recognized, however, that in the medical management of individuals with diabetes (and particularly in the case of juvenile diabetes) or patients in whom weight reduction and control are essential for health,
SEVERE EDEMATOUS CONJUNCTIVITIS FROM POWDERED ORRIS ROOT
Authors: Dunbar Roy
Journal: JAMA (1924)

During a long period of years including both private and dispensary practice, I never encountered a case similar to the one here reported. Nor have I been able to find in textbooks or monographs any reference to powdered orris root as a cause of ocular inflammation. <h3>REPORT OF CASE</h3> Mrs. T. J. B., aged 32, who consulted me, July 22, 1923, had been giving her hair a dry shampoo with orris root, when some of the powder accidentally fell into the right eye, without any immediate irritation. The next morning the lids of this eye were considerably swollen, and a membrane was sticking out from the eyeball itself. There was no pain or secretion. Both lids, especially the upper lid, were white and edematous. On attempting to open the palpebral fissure I found an edematous, chemotic condition involving the bulbar conjunctiva, so much so that the latter almost protruded through
Efficacy of Adenoidectomy for Recurrent Otitis Media in Children Previously Treated With Tympanostomy-Tube Placement
Authors: Jack L. Paradise
Journal: JAMA (1990)

We studied the efficacy of adenoidectomy in 213 children who had received tympanostomy-tube placement because of persistent and/or recurrent otitis media and had again developed otitis media after tubal extrusion. Ninety-nine of the children were assigned randomly to either an adenoidectomy group or a control group; in a separate trial, 114 children whose parents withheld consent for randomization were assigned according to parental preference. In both trials, control group outcomes appeared to have been biased favorably by the withdrawal of certain severely affected subjects from control status to receive adenoidectomy. Nonetheless, in both trials, adenoidectomy group outcomes were more favorable than control group outcomes during the first 2 follow-up years. Statistically significant differences were found mainly in the randomized trial, where during the first and second years, respectively, adenoidectomy subjects had 47% and 37% less time with otitis media than control subjects and 28% and 35% fewer suppurative (acute) episodes than control subjects. We conclude that adenoidectomy is warranted on an individualized basis for children who develop recurrent otitis media after extrusion of tympanostomy tubes.
Ascaris Pneumonia in a Two-Year-Old Girl
Authors: Robert D. Proffitt, Bryce C. Walton
Journal: New England Journal of Medicine (1962)

LöFFLER'S original description of the syndrome that he called "transitory lung infiltration with blood eosinophilia"1 and is now well known as Löffler's syndrome resulted from a study of cases of suspected tuberculosis. However, he suggested that the condition might be caused by a number of agents, including pulmonary ascariasis. In man experimental infections with Ascaris lumbricoides have been shown to produce Löffler's syndrome,2 and it is well established that this entity is common in regions where ascaris infections are highly prevalent. A somewhat similar clinical picture is elicited by the invasion of the lungs by other helminth parasites during their . . .
Clinical and Endoscopic Characterization of Depressed Gastric Adenoma
Authors: N. Tamai, M. Kaise, T. Nakayoshi, M. Katoh, K. Sumiyama, K. Gohda, T. Yamasaki, H. Arakawa, H. Tajiri
Journal: Endoscopy (2006)

Depressed gastric adenoma remains poorly characterized because it is rare, and is infrequently detected by endoscopy. The aim of this study was to elucidate clinical and endoscopic characteristics of depressed adenoma of the stomach.95 consecutive patients who underwent endoscopic resection of gastric adenomas were studied. Gastric adenomas, diagnosed according to the Vienna classification, were endoscopically classified into two types: depressed and protruding adenomas. In order to clarify endoscopic features of gastric adenomas, we performed indigo carmine chromoendoscopy as well as magnifying endoscopy with narrow band imaging, which yields clear images of mucosal microvasculature.12% of 100 gastric adenomas resected from 95 patients were depressed adenomas. Age and gender were comparable between patients with each type. Depressed adenomas (15.9 +/- 6.2 mm) were significantly larger in diameter than protruding adenomas (10.6 +/- 8.0 mm) (P = 0.01). Half of depressed adenomas were reddish in color, whereas only 18% of protruding adenomas were reddish. Magnifying endoscopy with narrow band imaging showed that 71% of depressed adenomas had a regular ultrafine network pattern of mucosal microvasculature, which was not seen in protruding adenomas. Intramucosal carcinomas were more frequently found in depressed adenomas (25%) than in protruding adenomas (4.5%).In comparison with protruding adenomas, depressed adenomas were rare and appeared endoscopically as large and reddish with a specific regular ultrafine network pattern of mucosal microvasculature. Depressed adenomas should be endoscopically resected because intramucosal carcinomas were found in a quarter of them.
Unravelling the Genetics of Ischaemic Stroke
Authors: Hugh S. Markus
Journal: PLoS Medicine (2010)

Epidemiological studies suggest genetic predisposition is important in stroke risk.
Monogenic conditions are important for the individual patient but do not account for much population attributable risk. An increasing number of such conditions are being described, particularly for the small vessel disease stroke subtype.
The candidate genes approach has proved disappointing in identifying genes contributing to the risk of multifactorial or polygenic stroke. This is a situation shared with other complex diseases.
Recently the GWAS (genome-wide association study) approach has identified genetic loci for many other cardiovascular diseases such as coronary heart disease, diabetes, and hypertension, and is just being applied to stroke. Some novel genetic variants initially associated with other cardiovascular diseases have recently been identified as risk factors in stroke populations.
Agoraphobia and Panic Disorder: 3.5 Years after Alprazolam and/or Exposure Treatment
Authors: Cengiz Kiliç, Homa Noshirvani, Metin Başoğlu, Isaac Marks
Journal: Psychotherapy and Psychosomatics (1997)

Long-term follow-ups after controlled studies of exposure therapy for agoraphobia/panic are few. Most of these studies found that improvement during treatment persists to the end of follow-up.Out of 69 patients with panic disorder plus agoraphobia who had been in an 8-week controlled study of alprazolam and/or exposure, 31 were followed up at a mean of 3.5 years later (4 years after trial entry). The 31 patients followed up included more cases who had relapsed at week 43 than did the group which did not attend the 3.5-year follow-up.As a group, followed-up cases maintained their gains over the 3.5 years, more so among ex-exposure than ex-relaxation cases. Ex-exposure patients did significantly better than relaxation patients on disability and survival time. Ex-alprazolam and ex-exposure patients did not differ significantly on any variable at the 3.5-year follow-up. No baseline variable predicted outcome at follow-up.Present results modestly confirm those of previous studies finding lasting improvement years after exposure, though some residual symptoms were the norm.
Infarction of Renal Allografts Demonstrated by Imaging with Tc-99m-DTPA
Authors: ROBERT W. BURT
Journal: Clinical Nuclear Medicine (1979)

The diagnosis of renal infarction on serial scintimages in renal allograft recipients is a relatively easy diagnosis. When the infarction is total or occupies a major portion of the kidney, the infarcted area will appear as photonpenic. Smaller infarctions will produce characteristic wedge shaped or oval defects along the kidney periphery. A possible source of error in interpretation is a recent biopsy procedure on the transplanted kidney.
Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 <b> <i>in Vitro</i> </b>
Authors: Peter J. Houghton, Glen S. Germain, Franklin C. Harwood, John D. Schuetz, Clinton F. Stewart, Elisabeth Buchdunger, Peter Traxler
Journal: Cancer Research (2004)

Abstract Imatinib mesylate (Gleevec, STI571) is a kinase inhibitor selective for Bcr-Abl, activated c-Kit kinases, and platelet-derived growth factor receptor tyrosine kinase. Imatinib mesylate, similar to many other tyrosine kinase inhibitors (TKIs), such as members of the 4-anilinoquinazoline class, competes for ATP binding. Previously, 4-anilinoquinazoline TKIs have been shown to inhibit the function of the breast cancer resistance-associated drug transporter (ABCG2), reversing resistance to camptothecin derivatives topotecan and SN-38. However, the potential to inhibit ABCG2 for the 2-phenylamino-pyrimidine class of TKIs, exemplified by imatinib mesylate, has not been examined. Here, we show that imatinib mesylate potently reverses ABCG2-mediated resistance to topotecan and SN-38 and significantly increases accumulation of topotecan only in cells expressing functional ABCG2. However, overexpression of ABCG2 does not confer resistance to imatinib mesylate. Furthermore, accumulation and efflux of [14C]imatinib mesylate are unaltered between ABCG2-expressing and non-ABCG2-expressing cells or by ATP depletion. These results suggest that imatinib mesylate inhibits the function of ABCG2 but is not a substrate for this transporter.
Actions and Interactions of Antithrombin and Heparin
Authors: Howard L. Bleich, Emily S. Boro, Robert D. Rosenberg
Journal: New England Journal of Medicine (1975)

THE coagulation of blood occurs via two pathways in which activation of specific plasma proteins initiates a cascade of reactions that ultimately lead to a fibrin clot. In the first pathway, injury to the endothelial cell layer exposes collagen1 , 2 or other subintimal components that activate Factor XII. Activated Factor XII activates Factor XI,3 which, in turn, activates Factor IX.4 Together with platelets and a cofactor, Factor VIII, activated Factor IX then activates Factor X.4 In the second pathway, subtle alterations in the endothelium expose tissue factor, which activates Factor VII,5 which in turn directly activates Factor X.5 Once activated by . . .
Relaxation and imagery in the treatment of breast cancer.
Authors: L. R. Bridge, P. Benson, P. C. Pietroni, R. G. Priest
Journal: BMJ (1988)

OBJECTIVE--To see whether stress could be alleviated in patients being treated for early breast cancer. DESIGN--Controlled randomised trial lasting six weeks. SETTING--Outpatient radiotherapy department in a teaching hospital. PATIENTS--One hundred fifty four women with breast cancer stage I or II after first session of six week course of radiotherapy, of whom 15 dropped out before end of study. INTERVENTION--Patients saw one of two researchers once a week for six weeks. Controls were encouraged to talk about themselves; relaxation group was taught concentration on individual muscle groups; relaxation and imagery group was also taught to imagine peaceful scene of own choice to enhance relaxation. Relaxation and relaxation plus imagery groups were given tape recording repeating instructions and told to practise at least 15 minutes a day. END POINT--Improvement of mood and of depression and anxiety on self rating scales. MEASUREMENTS AND MAIN RESULTS--Initial scores for profile of mood states and Leeds general scales for depression and anxiety were the same in all groups. At six weeks total mood disturbance score was significantly less in the intervention groups, women in the combined intervention group being more relaxed than those receiving relaxation training only; mood in the control group was worse. Women aged 55 and over benefited most. There was no difference in Leeds scores among the groups. CONCLUSIONS--Patients with early breast cancer benefit from relaxation training.
When Did I Know I Loved Her?
Authors: Edward V. Spudis
Journal: Annals of Internal Medicine (2000)

Ad Libitum15 August 2000When Did I Know I Loved Her?Edward V. Spudis, MDEdward V. Spudis, MDWinston-Salem, NC 27103 (Spudis)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-4-200008150-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Sitting on the U. of Maryland library steps in the sun herpleated, white tennis dress sent retinal micro-shivers cascadingthrough my alerted optic chiasm toward asymmetric area-seventeen sulci, which were then propelled into the nineteensfor, so-called, non-humuncular, dispositional representation—ignoring mischievous anti-sense oligonucleotide gene noise,hoping to achieve time-binding(ital) with her flirtatious auditoryparcels being sprayed backward from my naive anterior cinguli,prompting my immature, unlocalizeable personhood, i.e.,selfness, to say, “Where's your racket?” fifty years ago. Author, Article, and Disclosure InformationAffiliations: Winston-Salem, NC 27103 (Spudis)Corresponding Author: Edward V. Spudis, MD, Forsyth Medical Center, 3333 Silas Creek Parkway, Winston-Salem, NC 27103. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 2000Volume 133, Issue 4Page: 274KeywordsLibrariesOligonucleotides ePublished: 15 August 2000 Issue Published: 15 August 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Importance of Albumin Binding on Drug Action.
Authors: R. A. O'Reilly
Journal: Annals of Internal Medicine (1967)

s1 May 1967The Importance of Albumin Binding on Drug Action.R. A. O'Reilly, M.D., F.A.C.P., P. M. Aggeler, M.D., F.A.C.P.R. A. O'Reilly, M.D., F.A.C.P.Search for more papers by this author, P. M. Aggeler, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1062_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo study the impact of albumin binding on drug action we have used the coumarin anticoagulant, warfarin sodium, as a model because of the ease with which the drug itself and its biologic effect of hypoprothrombinemia can be quantitated in man. By use of electrochromatography and cellulose acetate electrophoresis the warfarin in plasma, after oral administration, was found to be bound exclusively to the albumin fraction. To determine the strength and the number of these binding sites, this interaction was studied by equilibrium dialysis with crystalline preparations of human albumin and warfarin sodium. The albumin showed a single, strong, primary... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Jose and San Francisco, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEnolic Acids with Antiinflammatory Activity 1 May 1967Volume 66, Issue 5Page: 1062-1063KeywordsAlbuminsAnticoagulantsBiologicsBlood plasmaCoumarinsDrugsEquilibrium dialysisOral administrationSodium Issue Published: 1 May 1967 PDF DownloadLoading ...
Method of Removing Abnormal Protein Rapidly from Patients with Malignant Paraproteinaemias
Authors: R. Powles, C. Smith, J. Kohn, G. H. Fairley
Journal: BMJ (1971)

On 48 occasions large quantities of abnormal protein were removed from the blood of 11 patients with malignant paraproteinaemias (plasmacytomas) by exchanging their plasma with reconstituted blood bank plasma. The IBM continuous flow blood cell separator was used to exchange the plasma, a procedure that is safe, very rapid, and with clinical benefits which are much better than can be obtained by conventional plasmapheresis. In addition, the constituents of reconstituted plasma correct deficiencies in normal immunoglobulins found in these patients. Clearly for the management of some patients with paraproteinaemia a cell separator is essential.
INCOMPATIBLE BLOOD TRANSFUSIONS
Authors: Maurice W. Black
Journal: JAMA (1960)

<h3>To the Editor:—</h3> With reference to the question inThe Journal, Jan. 2, page 119, regarding the largest amount of incompatible blood that has been given a patient who has survived the resulting reaction and to Dr. Crossley's observation inThe Journal, June 4, page 612, I would like to call attention to the article, "Transfusion Reactions and Their Treatment, Especially with the Artificial Kidney," by Barlas and Kolff, inThe Journal, April 25, 1959, page 1969. In this article, the authors reported a case in which a patient survived the transfusion of seven pints of incompatible blood with the aid of four treatments with the artificial kidney. The volume of incompatible blood transfused, though important, is probably only one of several vital factors that determine recovery in these cases.
Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate tolerance
Authors: Ulrich Hink, Matthias Oelze, Philip Kolb, Markus Bachschmid, Ming-Hui Zou, Andreas Daiber, Hanke Mollnau, Michael August, Stefan Baldus, Nikos Tsilimingas, Ulrich Walter, Volker Ullrich, Thomas Münzel
Journal: Journal of the American College of Cardiology (2003)
Double Uterus with Adenocarcinoma
Authors: D V Pojman, J B Taxy
Journal: New England Journal of Medicine (1995)

Figure 1. A posterior view of a double uterus from a 78-year-old woman with uterine bleeding is shown. On the right, an endometrial carcinoma (histologically classified as a grade II adenocarcinoma) has invaded the superficial third of the myometrium (arrow). The endometrium of the left fundus reveals cystic atrophy. The “s” indicates the septum between two endocervical canals.
Pulmonary Tuberculosis of Bovine Origin
Authors: L. J. Cutbill, A. Lynn
Journal: BMJ (1944)

FAINTING IN BLOOD DONORS MEDICALTIJOURNAL 283 appear from these figures that under existing circumstances between 5 and 6% of donors may be expected to show some symptoms during or immediately after blood withdrawal.Poles and Boycott consider that 1 in every 4 donors who faint loses consciousness; this high figure is obviously dependent in part upon the'r definition.In the present series only 13% lost consciousness.Figures are not given by Greenbury and Williams.The time in the bleeding procedure at which a faint occurs is variable, though the majority take place at the end of bleeding or shortly afterwards.In the present series 2%', occurred at venepuncture, compared with 0.05%)0' reported by Poles and Boycott.During bleeding 23%, of faints are recorded here.Poles and Boycott record the occurrence of 6% before 400 c.cm. was withdrawn and of 57% in the latter part of bleeding.In the present series 34%/ occurred.just before withdrawal of the needle and 16% shortly afterwards, while 25' happened during the rest period, compared with 19%-t. in this period mentioned by Poles and Boycott.The latter workers record 14 ,, of delayed faints occurring after return to work, applying the term " faint" to anyone who either loses consciousness or can obviously neither sit nor stand without doIng so.Within this definition only 1.8%O of women and 1.2 ,, of men in the present series fainted after they had left the depot.No explanation of this difference is available.With the exception of Poles and Boycott.who describe a
LONG-TERM EXPOSURE TO TRAFFIC RELATED AIR POLLUTION AND ENDOTHELIAL DYSFUNCTION: MULTIETHNIC STUDY OF ATHEROSCLEROSIS AND AIR POLLUTION (MESA AIR)
Authors: Ranjini M. Krishnan, Sara D. Adar, Adam A. Szpiro, Neal W. Jorgensen, Assaf P. Oron, Victor C. Van Hee, Marie S. O'Neill, R. Graham Barr, David M. Herrington, Joseph F. Polak, Joel D. Kaufman
Journal: Journal of the American College of Cardiology (2013)