tbuckley/cabot-search huggingface dataset:
Electrophysiologic spectrum of concealed intranodal conduction during atrial rate acceleration in a model of 2:1 atrioventricular block.
Authors: J McKinnie, B Avitall, J Caceres, M Jazayeri, P Tchou, M Akhtar
Journal: Circulation (1989)

Concealed anterograde penetration of the atrioventricular (AV) node has been used to explain a wide variety of electrocardiographic findings. The effects of atrial rate acceleration on this phenomenon remain undefined. To examine the dynamic interrelations between conducted and nonconducted beats at different atrial rates, a unique atrial pacing protocol of functional 2:1 AV block was used in 10 patients. The pacing protocol involved abrupt transitions from 2:1 to 1:1 AV conduction and enabled quantification of conduction delay produced by nonpropagated impulses over extremes of atrial rate. Stable 2:1 AV conduction was maintained over a mean range of atrial paced cycle lengths of 289 +/- 29.6 to 223 +/- 33.0 msec, respectively. The mean AV conduction time during 2:1 and corresponding 1:1 drives at the longest atrial paced rates were 169 +/- 33.5 and 136.5 +/- 26.9 msec, respectively--revealing a significant effect of nonpropagated impulses on subsequent conduction. Surprisingly, at the shortest atrial paced rates, the mean AV conduction times were 191.5 +/- 31.8 and 161.0 +/- 23.3 msec, respectively. The lack of significant changes in conduction time between 2:1 and 1:1 drives at the extremes of atrial rate (32.5 vs. 30 msec, p = NS) suggests that the effect of concealed conduction is "fixed" and independent of rate. Clinical implications and postulated electrophysiologic mechanisms are discussed.
GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak
Authors: Yvonne G. Weber, Alexander Storch, Thomas V. Wuttke, Knut Brockmann, Judith Kempfle, Snezana Maljevic, Lucia Margari, Christoph Kamm, Susanne A. Schneider, Stephan M. Huber, Arnulf Pekrun, Robert Roebling, Guiscard Seebohm, Saisudha Koka, Camelia Lang, Eduard Kraft, Dragica Blazevic, Alberto Salvo-Vargas, Michael Fauler, Felix M. Mottaghy, Alexander Münchau, Mark J. Edwards, Anna Presicci, Francesco Margari, Thomas Gasser, Florian Lang, Kailash P. Bhatia, Frank Lehmann-Horn, Holger Lerche
Journal: Journal of Clinical Investigation (2008)

Paroxysmal dyskinesias are episodic movement disorders that can be inherited or are sporadic in nature. The pathophysiology underlying these disorders remains largely unknown but may involve disrupted ion homeostasis due to defects in cell-surface channels or nutrient transporters. In this study, we describe a family with paroxysmal exertion-induced dyskinesia (PED) over 3 generations. Their PED was accompanied by epilepsy, mild developmental delay, reduced CSF glucose levels, hemolytic anemia with echinocytosis, and altered erythrocyte ion concentrations. Using a candidate gene approach, we identified a causative deletion of 4 highly conserved amino acids (Q282_S285del) in the pore region of the glucose transporter 1 (GLUT1). Functional studies in Xenopus oocytes and human erythrocytes revealed that this mutation decreased glucose transport and caused a cation leak that alters intracellular concentrations of sodium, potassium, and calcium. We screened 4 additional families, in which PED is combined with epilepsy, developmental delay, or migraine, but not with hemolysis or echinocytosis, and identified 2 additional GLUT1 mutations (A275T, G314S) that decreased glucose transport but did not affect cation permeability. Combining these data with brain imaging studies, we propose that the dyskinesias result from an exertion-induced energy deficit that may cause episodic dysfunction of the basal ganglia, and that the hemolysis with echinocytosis may result from alterations in intracellular electrolytes caused by a cation leak through mutant GLUT1.
Molecular Predictors of Response to Epidermal Growth Factor Receptor Antagonists in Non–Small-Cell Lung Cancer
Authors: Lecia V. Sequist, Daphne W. Bell, Thomas J. Lynch, Daniel A. Haber
Journal: Journal of Clinical Oncology (2007)

In the last 5 years the epidermal growth factor receptor (EGFR) has emerged as one of the most important targets for drug development in oncology. Monoclonal antibodies targeting the external domain of EGFR have been shown to have clinical benefit in colorectal and head and neck cancer when combined with chemotherapy and/or radiation. Small molecules that inhibit the tyrosine kinase (TK) domain of EGFR have become critical new weapons in the treatment of non-small-cell lung cancer (NSCLC). The discovery that mutations in the TK domain are associated with dramatic and sustained responses to EGFR TK inhibitors (TKIs) has allowed the design of trials to test these agents as potential first-line therapies and has provided a fascinating window into the future of genotype-directed targeted therapy. Recent advances in understanding the biologic basis of acquired resistance to these agents have great potential to improve the clinical effectiveness of this class of drugs. This review summarizes the biology of EGFR in NSCLC, the clinical and molecular predictors of benefit from treatment with EGFR TKIs, the use of patient-specific molecular profiling, and future directions of clinical and basic scientific research.
Future of quality measurement
Authors: Helen Lester, Martin Roland
Journal: BMJ (2007)

General practitioners have responded well to current UK performance targets. Helen Lester and Martin Roland examine the options for keeping up the progress In the past decade there has been sustained international interest in measuring quality of care. In the United Kingdom, quality indicators with financial incentives to reward good care were introduced as a result of increasing awareness of variable quality in primary care, the technical feasibility of introducing evidence based indicators within information technology systems, and a resolve by political negotiators to use improved quality to secure additional investment in primary care.1 Similar but less comprehensive initiatives have been introduced in the United States, Europe, Australia, and New Zealand. However, as this series has shown, the use of quality measures has also created controversy. Our view is that using incentives to improve quality of care has been beneficial. We look at what needs to be done to ensure those benefits remain in the future. The quality and outcomes framework, which forms the basis of quality measurement in UK primary care, could be developed in several different ways:
901-84 Prognostic Value of Right Heart Catheterization Hemodynamic Data in Surgically Treated Patients with Coronary Artery Disease
Authors: William R. Hathaway, Steven E. McNulty, Karen Pieper, Frank E. Harrell, Daniel B. Mark, Robert H. Jones, Thomas M. Bashore, Robert M. Califf, Christopher M. O’Connor
Journal: Journal of the American College of Cardiology (1995)
Sodium and Procaine Penicillin in Treatment of Experimental Staphylococcal Infection in Mice
Authors: F. R. Selbie
Journal: BMJ (1954)

MECKEL'S DIVERTICULUM MEJOURNAL tions with a high mortality (about 15% according to Wagner et al., 1950) it can provoke, any incidentally found Meckel's diverticulum should be removed if this procedure does not materially increase the operative risk. SummaryThe complications of Meckel's diverticulum which call for emergency surgery are infection, obstruction, intussusception, volvulus, and haemorrhage.The diffi- culties in diagnosis have been illustrated by five cases.The incidentally found Meckel's diverticulum should be removed if this procedure does not materially increase the operative risk.
Displaying Fel d1 on virus-like particles prevents reactogenicity despite greatly enhanced immunogenicity: a novel therapy for cat allergy
Authors: Nicole Schmitz, Klaus Dietmeier, Monika Bauer, Melanie Maudrich, Stefan Utzinger, Simone Muntwiler, Philippe Saudan, Martin F. Bachmann
Journal: The Journal of Experimental Medicine (2009)

Allergen-specific desensitization is the only disease-modifying therapy currently available for the treatment of allergies. These therapies require application of allergen over several years and some may induce life-threatening anaphylactic reactions. An ideal vaccine for desensitization should be highly immunogenic and should alleviate allergic symptoms upon few injections while being nonreactogenic. We describe such a vaccine for the treatment of cat allergy, consisting of the major cat allergen Fel d1 coupled to bacteriophage Qbeta-derived virus-like particles (Qbeta-Fel d1). Qbeta-Fel d1 was highly immunogenic, and a single vaccination was sufficient to induce protection against type I allergic reactions. Allergen-specific immunoglobulin G antibodies were shown to be the critical effector molecules and alleviated symptoms by two distinct mechanisms. Although allergen-induced systemic basophil degranulation was inhibited in an FcgammaRIIb-dependent manner, inhibition of local mast cell degranulation in tissues occurred independently of FcgammaRIIb. In addition, treatment with Qbeta-Fel d1 abolished IgE memory responses upon antigen recall. Despite high immunogenicity, the vaccine was essentially nonreactogenic and vaccination induced neither local nor systemic anaphylactic reactions in sensitized mice. Moreover, Qbeta-Fel d1 did not induce degranulation of basophils derived from human volunteers with cat allergies. These data suggest that vaccination with Qbeta-Fel d1 may be a safe and effective treatment for cat allergy.
Factors influencing serum immunoglobulin E levels in Greek children
Authors: E. Petridou, M. Kanariou, M. Liatsis, K. Spanou, K. Revinthi, K. Mandalenaki‐Lambrou, D. Trichopoulos
Journal: Allergy (1995)

Serum levels of immunoglobulin E (IgE) were determined by enzyme immunoassay in 414 Greek infants and children of both sexes, 1 month to 14 years old. The children were admitted to the “Aghia Sophia” Teaching Hospital for Children (Athens, Greece) for surgical corrections of minor anatomic abnormalities, but they were otherwise healthy. Statistical analysis was performed through multiple regression after logarithmic transformation of the immunoglobulin values. IgE levels increased significantly by about 80°, per year up to the age of 5 years, without noticeable impact of age on these levels thereafter. History of allergic disease showed a significant positive association with serum levels of IgE in both younger (less than 5 years) and older children. History of frequent infections was positively associated with IgE levels, although the relation was statistically significant only in the older age group. IgE levels in Greek children appear to be higher than the corresponding levels of children living in northern Europe, but much lower than those of children in Southeast Asia, a fact that may reflect different exposure level during childhood to infections known to influence IgE levels.
Chemokines activate Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor in mammalian cells in culture.
Authors: M C Gershengorn, E Geras-Raaka, A Varma, I Clark-Lewis
Journal: Journal of Clinical Investigation (1998)

Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8, a virus that appears to be involved in the pathogenesis of Kaposi's sarcoma and primary effusion lymphomas, encodes a G protein-coupled receptor (KSHV-GPCR) that exhibits constitutive signaling. In this report, we show that two chemokines, interleukin 8 (IL-8) and growth-related protein-alpha, activate KSHV-GPCR over constitutive levels. Moreover, as with human receptors, the integrity of the ELR motif of these chemokines is required for activation of KSHV-GPCR. Other residues that are required for IL-8 binding to human chemokine receptors CXCR1 and CXCR2 are important for KSHV-GPCR activation also. Thus, it appears that the ELR binding site and other key domains of ELR chemokine activation have been preserved in the virus KSHV-GPCR. The results suggest that KSHV-GPCR originated from CXCR1 or CXCR2 and that activation of KSHV-GPCR by endogenous chemokines may affect the pathobiology of KSHV infection in humans.
Cocaine-mediated induction of platelet-derived growth factor: implication for increased vascular permeability
Authors: Honghong Yao, Ming Duan, Shilpa Buch
Journal: Blood (2010)

Neuroinflammation associated with advanced HIV-1 infection is often exacerbated in cocaine-abusing, HIV-infected patients. The underlying mechanisms could, in part, be attributed to the increased impairment of blood brain barrier integrity in the presence of cocaine. Platelet-derived growth factor (PDGF) has been implicated in several pathologic conditions, specifically attributable to its potent mitogenic effects. Its modulation by drug abuse, however, has received very little attention. In the present study, we demonstrated cocaine-mediated induction of PDGF-BB in human brain microvascular endothelial cells through the binding to its cognate σ receptor. Furthermore, this effect was mediated, with subsequent activation of mitogen-activated protein kinases and Egr-1 pathways, culminating ultimately into increased expression of PDGF-BB. Cocaine exposure resulted in increased permeability of the endothelial barrier, and this effect was abrogated in mice exposed to PDGF-BB neutralizing antibody, thus underscoring its role as a vascular permeant. In vivo relevance of these findings was further corroborated in cocaine-treated mice that were administered neutralizing antibody specific for PDGF-BB as well as in Egr-1(-/-) mice. Understanding the regulation of PDGF-BB expression may provide insights into the development of potential therapeutic targets for neuroinflammation associated with HIV infection and drug abuse.
European court upholds UK ban on Halcion
Authors: C. Dyer
Journal: BMJ (1999)

The manufacturer of the sleeping pill triazolam (Halcion), banned from sale in the United Kingdom since 1993,has failed in its attempt to invoke European Community law to get the ban reconsidered.

The European Court of Justice in Luxembourg has held that the UK system for challenging drug bans by judicial review proceedings in the High Court complies with European Community law.

In judicial review …
Difficulties of Proof in Malpractice — Informed Consent and Res Ipsa Loquitur
Authors: William J. Curran
Journal: New England Journal of Medicine (1970)

TWO recent medical-malpractice cases passed down by important state courts illustrate the difficulties of physician defense against suits based upon the two favorite plaintiff doctrines of courtroom attack: failure to obtain "informed consent"; and res ipsa loquitur.The first case, which has received a marked degree of attention among the personal-injury bar, is Darrah v. Kite.1 This was a decision of the Appellate Division of the Supreme Court in New York reversing a jury verdict for the defendant and ordering a new trial on the issue of "informed consent." A neurosurgeon had recommended hospitalization for a diagnostic work-up on a . . .
Megavoltage Radiation of the Pituitary in Cushing's Syndrome.
Authors: Walter L. Arons
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Megavoltage Radiation of the Pituitary in Cushing's Syndrome.Walter L. Arons, M.D., F.A.C.P., Carlos A. Camargo, M.D., Charles L. Murray, M.D., Gerald M. Reaven, M.D., Richard A. Borrison, M.D., Malcolm A. Bagshaw, M.D., John A. Luetscher, M.D.Walter L. Arons, M.D., F.A.C.P.Search for more papers by this author, Carlos A. Camargo, M.D.Search for more papers by this author, Charles L. Murray, M.D.Search for more papers by this author, Gerald M. Reaven, M.D.Search for more papers by this author, Richard A. Borrison, M.D.Search for more papers by this author, Malcolm A. Bagshaw, M.D.Search for more papers by this author, John A. Luetscher, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-790_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this study was to evaluate pituitary megavoltage radiation in the treatment of Cushing's syndrome associated with adrenal hyperplasia. To date 12 such patients have been treated with a mean tissue dose of 4500 rads delivered to the pituitary area by the Stanford Linear Accelerator. Eight patients responded impressively by both clinical and laboratory measurements—seven of them within 1 to 12 months—after pituitary radiation and have remained free of evidence of hypercorticism to date. Follow-up on these patients has extended from 1 to 8 years with a mean interval since treatment of 5 years. Four patients—two with severe... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Stanford, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 790-790KeywordsClinical laboratoriesResearch laboratories Issue Published: 1 May 1970 PDF DownloadLoading ...
Hepatosplenic Candidiasis Imaged With F-18 FDG PET/CT
Authors: Pierre Teyton, Georges Baillet, Elif Hindié, Jean Emmanuel Filmont, Farid Sarandi, Marie-Elisabeth Toubert, Jean Luc Moretti
Journal: Clinical Nuclear Medicine (2009)

We report a case of hepatosplenic candidiasis imaged with F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT). A 22-year-old man receiving treatment for acute myeloid leukemia presented with fever. Hepatosplenic candidiasis was diagnosed based on the presence of hepatosplenic micro abscesses on CT. Fever persisted in spite of fluconazole treatment. F-18 FDG PET/CT scan was performed to rule out persistent hepatosplenic infection or other organ involvement. PET showed multiple intense uptake foci throughout the liver and spleen. The fungicidal drug was changed. The patient improved. We conclude that it would be interesting to investigate the use of F-18 FDG PET/CT in the work-up of systemic candidiasis.
Effect of Insulin Glulisine on Microvascular Blood Flow and Endothelial Function in the Postprandial State
Authors: Clothilde Hohberg, Thomas Forst, Martin Larbig, Michael Safinowski, Stefan Diessel, Silvia Hehenwarter, Matthias M. Weber, Thomas Schöndorf, Andreas Pfützner
Journal: Diabetes Care (2008)

To investigate the effect of insulin glulisine on postprandial microvascular blood flow in type 2 diabetes.A total of 15 patients with type 2 diabetes received insulin glulisine or human insulin before a liquid meal test. Thereafter, skin microvascular blood flow was measured by laser Doppler fluxmetry and blood samples were taken for measurement of plasma levels of glucose, insulin, intact proinsulin, asymmetric dimethylarginine, nitrotyrosine, interleukin-18, matrix metalloproteinase-9, oxidized LDL, and free fatty acids.Insulin glulisine injections resulted in higher postprandial insulin levels (means +/- SEM area under the curve [AUC](0-120) 51.0 +/- 6.8 vs. 38.2 +/- 5.4 mU/l; P = 0.004), while plasma glucose (AUC(0-240) 158 +/- 9 vs. 180 +/- 9 mg/dl; P < 0.05) and intact proinsulin (AUC(0-240) 26.2 +/- 3.5 vs. 31.2 +/- 4.3 pmol/l; P = 0.002) were lower. Microvascular blood flow increased after insulin glulisine injection (27.9 +/- 3.1 to 51.7 +/- 9.9 arbitrary units [AU]; P < 0.05), while only a minor increase was found during human insulin (27.9 +/- 3.1 to 34.4 +/- 7.8 AU; not significant). Asymmetric dimethylarginine and nitrotyrosine levels were reduced after insulin glulisine (P < 0.05).Insulin glulisine is superior to human insulin in restoring postprandial metabolic and microvascular physiology.
The Role of the Psychotherapist in a Changing Society
Authors: Isidore Ziferstein
Journal: Psychotherapy and Psychosomatics (1975)

Research Articles| February 12 2010 The Role of the Psychotherapist in a Changing Society Subject Area: Psychiatry and Psychology Isidore Ziferstein Isidore Ziferstein Los Angeles Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1975) 25 (1-6): 283–286. https://doi.org/10.1159/000286882 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Isidore Ziferstein; The Role of the Psychotherapist in a Changing Society. Psychother Psychosom 31 December 1975; 25 (1-6): 283–286. https://doi.org/10.1159/000286882 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1975Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.