Verapamil Toxicity—Treatment with Hemoperfusion
Authors: Steven J. Rosansky
Journal: Annals of Internal Medicine (1991)

Letters15 February 1991Verapamil Toxicity—Treatment with HemoperfusionSteven J. Rosansky, MDSteven J. Rosansky, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-4-340 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Verapamil is cleared from the body by hepatic metabolism. Renal and dialytic clearance of verapamil and its active metabolite norverapamil generally are not clinically important (1-3). Nevertheless, in patients whose liver metabolic function is inhibited, the removal of verapamil by dialytic methods may become important. We report a case of verapamil intoxication in which hemoperfusion was used to remove verapamil and norverapamil.A 48-year-old hypertensive man was admitted for a urethrotomy. The patient drank one litre of "whiskey" on weekends. He was receiving 240 mg/d of sustained-release verapamil and 400 mg/d of tagamet. The patient's blood pressure...References1. Mooy J, Schols M, and v Baak M. Pharmacokinetics of verapamil in patients with renal failure. Eur J Clin Pharmacol. 1985;28:405-10. CrossrefMedlineGoogle Scholar2. Shah G and Winer R. Verapamil kinetics during maintenance hemodialysis. Am J Nephrol. 1985;5:338-41. CrossrefMedlineGoogle Scholar3. Hanyok J, Chow M, and Kluger J. An evaluation of the pharmacokinetics, pharmacodynamics, and dialyzability of verapamil in chronic hemodialysis patients. J Clin Pharmacol. 1988;28:831-6. CrossrefMedlineGoogle Scholar4. Somogyi A and Gugler R. Drug interactions with cimetidine. Clin Pharmacokinet. 1982;7:23-41. CrossrefMedlineGoogle Scholar5. Woodcock B, Rietbrock I, and Vohringer H. Verapamil disposition in liver disease and intensive-care patients: kinetics, clearance, and apparent blood flow relationships. Clin Pharmacol Ther. 1981;29:1:27-34. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Steven J. Rosansky, MDAffiliations: Wm. Jennings Bryan Dorn Veterans Hospital University of South Carolina School of Medicine Columbia, SC 29208 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExtracorporeal treatment for calcium channel blocker poisoning: systematic review and recommendations from the EXTRIP workgroupTreatment of Severe Amlodipine Toxicity With Molecular Adsorbent Recirculating SystemPoisoningTreatment for calcium channel blocker poisoning: A systematic reviewHemoperfusion for the Treatment of Poisoning: Technology, Determinants of Poison Clearance, and Application in Clinical PracticeCalcium Channel Blocker ToxicityPoisoning: Kinetics to TherapeuticsCalcium Channel Blocker Ingestion: An Evidence-Based Consensus Guideline for Out-of-Hospital ManagementAdult Toxicology in Critical CareaManagement of Calcium Channel Antagonist OverdoseNeurological Recovery after Prolonged Verapamil-Induced Cardiac ArrestApproach to the cardiac effects of beta blocker and calcium channel blocker overdoseApproach to the poisoned patientComplications of verapamil in psychiatryA Case of Calcium Channel Blocker Overdoseβ-Blocker and Calcium Channel Blocker ToxicityVerapamil intoxication: A literature review of overdoses and discussion of therapeutic options 15 February 1991Volume 114, Issue 4Page: 340-341KeywordsBlood pressureHemoperfusionIntoxicationLiverMetabolites ePublished: 1 December 2008 Issue Published: 15 February 1991 PDF downloadLoading ...