tbuckley/cabot-search huggingface dataset:
Endoscopic Papillary Balloon Dilation vs. Sphincterotomy for Removal of Common Bile Duct Stones: A Prospective Randomized Pilot Study
Authors: J. C. Arnold, C. Benz, W. R. Martin, H. E. Adamek, J. F. Riemann
Journal: Endoscopy (2001)

Background and Study Aims: Endoscopic sphincterotomy (EST) is the standard procedure for gaining access to the common bile duct for removal of bile duct stones. However, the procedure is associated with both short-term and long-term complications. Recent reports have described the use of endoscopic papillary balloon dilation (EBD) as an effective and safe alternative to EST. We conducted a prospective randomized pilot study to compare the efficacy and short-term complication rates of these two established methods for removing uncomplicated bile duct stones.
Malignant Carcinoid Presenting as Anuria
Authors: Paul M. Kirkman
Journal: JAMA (1969)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physicians Contribute Professional Expertise Worldwide
Authors: Jennifer Fisher Wilson
Journal: Annals of Internal Medicine (2003)

Current Clinical Issues17 June 2003Physicians Contribute Professional Expertise WorldwideJennifer Fisher WilsonJennifer Fisher WilsonSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-12-200306170-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Sheri Lee Fink, MD, PhD, was one of the first nonmilitary U.S. physicians to arrive in Iraq after the 2003 conflict started. Part of the International Medical Corps (IMC), a Los Angelesbased nonprofit emergency relief organization, she waded into the chaotic postwar zone to assess the health care needs of the Iraqi people and organize aid for them. Despite the uncertain conditions she would find in Iraq, Fink sounded calm in the days before she caught a flight from her New York City home in early April. It's hardly the first time she has landed in the midst of instability ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHealth care workers in conflict and post-conflict settings: Systematic mapping of the evidence 17 June 2003Volume 138, Issue 12Page: 1013-1016KeywordsCyclic adenosine monophosphateDrugsGastroenterology and hepatologyHealth careHealth care providersHospital medicineMedical educationMuscular dystrophiesSub-specialty careUltrasound imaging ePublished: 17 June 2003 Issue Published: 17 June 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
The effect of E. coli on the absorption of vitamin B12
Authors: C. C. Booth, J. Heath
Journal: Gut (1962)

Cultures of <i>E. coli</i> are capable of inhibiting the absorption of vitamin B<sub>12</sub> in the rat. Their inhibitory effect is totally abolished when the organisms are killed by heat and partially abolished when test doses of labelled B<sub>12</sub> are previously bound by intrinsic factor.
A111-a: Setting Up of Japanese Online Registry of Pediatric Rheumatic Disease
Authors: Ken-ichi Yamaguchi, Yasuhito Nerome, Tomoyuki Imagawa
Journal: Arthritis & Rheumatology (2014)

Background/Purpose:

Performing quality clinical and translational research in pediatric rheumatic diseases (eg. Juvenile Idiopathic Arthritis (JIA), Child onset Systemic Lupus Erythematosus (cSLE) and Juvenile Dermatomyositis (JDM)) had been difficult due the rarity of these diseases.



Methods:

Professor Takei, the former chairman of Pediatric Rheumatology Association of Japan (PRAJ), had ordered his working group to set up a new registry system in 2012. We, working group, have set up Japanese online registry for pediatric rheumatic disease in 2014 and have named it as Pediatric Rheumatology International Collaboration Unit Registry (PRICURE).



Results:

Under this registry, PRAJ will collect basic information (e.g. age of onset, sex, symptoms, major complication, main treatment) about these diseases (JIA, SLE, JDM, Sjogren syndrome, Mixed Connective Tissue Disease, Systemic Sclerosis, Behcet's disease, Vasculitis, Autoinflammatory syndromes, Fibromyalgia).



Conclusion:

We had set up new registry of pediatric rheumatic diseases. We will show initial data from this registry here.
Problems of the oncology outpatient: role of the liaison health visitor.
Authors: J M Trotter, R Scott, F R Macbeth, J G McVie, K C Calman
Journal: BMJ (1981)

A survey by a liaison health visitor of outpatients attending an oncology department has identified and enumerated the principal problems with which she is confronted, and defined her role. The main medical symptoms of concern to the patient at home and needing attention by the liaison health visitor were anorexia, nausea, vomiting, and constipation: inadequate pain control due to poor drug compliance was also common. Other functions of the liaison health visitor include providing nursing aids and prostheses, support for bereaved relatives, and liaison with the community health care team.
Operational and Financial Outcomes of Shared Laboratory Services in a Consolidated Hospital System
Authors: Garabed A. Fattal
Journal: JAMA (1985)

The clinical laboratories of three hospitals were consolidated under a single directorship. Improvements in available services and substantial true cost savings were achieved. These results illustrate the theoretically anticipated but rarely documented advantages of a shared-hospital services model of health care provision. (<i>JAMA</i>1985;253:2076-2079)
Hypoxia-induced modulation of endothelial cell properties: Regulation of barrier function and expression of interleukin-6
Authors: Shi Fang Yan, Satoshi Ogawa, David M. Stern, David J. Pinsky
Journal: Kidney International (1997)

The endothelial cell response to hypoxia involves a range of adaptive mechanisms that reflect an active response of the cell's biosynthetic and metabolic apparatus. Hypoxia-mediated suppression of endothelial barrier function, resulting in increased vascular leakage, is likely to contribute to pulmonary and cerebral edema associated with high altitude and is closely associated with a fall in intracellular cyclic AMP levels. Buttressing of this second messenger pathway in the endothelium using membrane permeant cyclic AMP analogs prevents increased vascular leakage due to hypoxia. Application of this principle to organ preservation has shown that supplementation with cyclic AMP analogs or inhibition of endogenous cAMP metabolism enables extension of the time a harvested organ can remain extracorporeally, after which transplantation is successful. The underlying mechanism through which cyclic AMP exerts its effects appears to be maintenance of vascular homeostasis in the graft. A distinct adaptive mechanism triggered in the endothelium by hypoxia is expression of the cytokine interleukin-6 (IL-6) by a novel mechanism involving transcription driven by the nuclear factor IL-6 (NF-IL-6) DNA binding site in the promoter. IL-6 may exert protective effects on vascular function, thereby limiting vascular injury by a different mechanism than those recruited by elevated cAMP levels. These studies provide insights into tow independent mechanisms through which endothelium responds to oxygen deprivation, and suggest possible new approaches to attentuate vascular injury associated with ischemia.
Immunologic and Genetic Factors in Autoimmune Diseases
Authors: Yehuda Shoenfeld, Robert S. Schwartz
Journal: New England Journal of Medicine (1984)

RECENT advances have solidified the development of immunology as a laboratory discipline and accelerated its evolution as a clinical science. An important benefit of this progress is the improvement in our understanding of autoimmunity. In this article we will review current aspects of that subject. The extensive literature required us to restrict our analysis to certain topics; those we have chosen to emphasize concern newly discovered immunologic and genetic mechanisms. The autoimmune diseases that exemplify these recent developments include systemic lupus erythematosus, Graves' disease, Type I diabetes mellitus, and myasthenia gravis. We will therefore focus on them but deal with . . .
Alprazolam decreases isoproterenol induced myocardial damage in the rat
Authors: K BERKOWITZ, S CONAHAN, W H VOGEL
Journal: Cardiovascular Research (1988)

Myocardial trauma and damage were induced by two doses of isoproterenol 40 mg·kg−1 in rats. Isoproterenol injections alone caused the expected cardiotoxicity. Two doses of alprazolam 0.5 mg·kg−1 decreased the severity of electrocardiographic changes after isoproterenol injection and the amount of myocardial tissue damage. The frequency of ischaemic ST-T changes, flat or inverted T waves, Q wave appearance, and heart block was significantly reduced in the alprazolam group. The alprazolam treated group had a significantly smaller proportion of infarcted tissue in the ventricular section (2.3%) and in the apical sections (1.8%) than the vehicle injected rats (6.5% and 14.7% respectively). There was no difference in wet heart weight or in heart rate between the alprazolam group and the control group. These results show that alprazolam has a cardioprotective effect in rats treated with cardiac damaging doses of isoproterenol.
Arterial disease in chronic leg ulceration: an underestimated hazard? Lothian and Forth Valley leg ulcer study.
Authors: M J Callam, D R Harper, J J Dale, C V Ruckley
Journal: BMJ (1987)

Six hundred patients with chronic leg ulcers were interviewed and examined for evidence of arterial impairment. There were 827 ulcerated legs. Pedal pulses could not be felt in 94 (11%). A Doppler resting pressure index of 0.9 or less was found in 176 legs (21%). Risk factors for arterial impairment included age, ulceration affecting the foot, and a history of claudication, ischaemic heart disease, or cerebrovascular disease. Roughly half the patients with arterial impairment also showed the clinical features of chronic venous insufficiency. Careful assessment for arterial disease is mandatory before patients with chronic leg ulcers are treated with elastic compression.
The Regulation of Testicular Descent and the Effects of Cryptorchidism
Authors: John M. Hutson, Bridget R. Southwell, Ruili Li, Gabrielle Lie, Khairul Ismail, George Harisis, Nan Chen
Journal: Endocrine Reviews (2013)

Abstract The first half of this review examines the boundary between endocrinology and embryonic development, with the aim of highlighting the way hormones and signaling systems regulate the complex morphological changes to enable the intra-abdominal fetal testes to reach the scrotum. The genitoinguinal ligament, or gubernaculum, first enlarges to hold the testis near the groin, and then it develops limb-bud-like properties and migrates across the pubic region to reach the scrotum. Recent advances show key roles for insulin-like hormone 3 in the first step, with androgen and the genitofemoral nerve involved in the second step. The mammary line may also be involved in initiating the migration. The key events in early postnatal germ cell development are then reviewed because there is mounting evidence for this to be crucial in preventing infertility and malignancy later in life. We review the recent advances in what is known about the etiology of cryptorchidism and summarize the syndromes where a specific molecular cause has been found. Finally, we cover the recent literature on timing of surgery, the issues around acquired cryptorchidism, and the limited role of hormone therapy. We conclude with some observations about the differences between animal models and baby boys with cryptorchidism.
DEPENDENCY OF CARDIAC RESYNCHRONIZATION THERAPY ON MYOCARDIAL VIABILITY AT THE LEFT VENTRICULAR LEAD POSITION
Authors: Michael Becker, Christian Zwicker, Markus Kaminski, Andreas Napp, Ertunc Altiok, Patrick Schauerte, Christina Ocklenburg, Nikolaus Marx, Rainer Hoffmann
Journal: Journal of the American College of Cardiology (2011)
FETID MENSTRUATION, OR FŒTEO-MENORRHCEA.
Authors: WILLIAM B. DeWEES
Journal: JAMA (1889)

The natural odor of the menstrual discharge is peculiar, but not offensive. It is an odor<i>sui generis,</i>and has been compared to that of the marigold<i>(calendula officinalis)</i>, fish brine, etc. It is most pungent in women of darker or lighter complexion, e. g., in negro and in red-haired women it is often very strong. Virchow attributes it to the presence of fatty acids. But it is not the peculiar natural odor pervading menstruants that we wish to bring to the attention of the reader. It is the abnormal odor contracted by the flux at or before its emergence from the uterus. To differentiate the two in all cases may become difficult, but the distinction must be borne in mind while endeavoring to make a proper diagnosis. Every physician of experience no doubt has had—like myself— a number of cases of fetid menstruation—<i>Fluxus Menstrualis Fœtidus</i>—for which I would propose,
Mortal Secrets: Truth and Lies in the Age of AIDS
Authors: Tamsin Wilton
Journal: BMJ (2004)

Much has been written about the psychological and social implications of HIV infection for individuals, their intimates, and their communities. Yet, perhaps surprisingly, Klitzman and Bayer are correct in their assertion that theirs is the first detailed study of disclosure, the process whereby individuals make their serostatus for HIV known to others. Robert Klitzman, Ronald Bayer The Johns Hopkins University Press, $42, pp 218 ISBN 0801874270 http://www.press.jhu.edu/ Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> Disclosure has important implications, both for prevention and for the success of therapeutic intervention. An HIV positive person who does not disclose may increase the likelihood … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
Abstract LB-42: In vivo screen for novel breast cancer promoting genes.
Authors: Yongliang Huo, Ian Macara
Journal: Cancer Research (2013)

Abstract Mis-regulation of oncogenes and tumor suppressor genes causes cancer. Although the evolution of cancer is not conclusive, most evidence supports that tumors arise from collaboration of multiple genes. To better understand the process of breast tumor initiation and cancer progression we carried out an in vivo screen, for genes that promote tumor formation. Our screen was performed using lentiviral transduction of primary murine mammary epithelial cells, and orthotopic implantation into syngeneic recipient mice. Wild type mammary stem cells can regenerate an entire mammary ductal tree in the recipients. We chose a well-characterized ErbB2/Her2 over-expression mouse model as a source of donor cells because HER2 over-expression occurs in &amp;gt;20% of human breast cancer patients. A cDNA library consisting of a “druggable” set of ~1000 genes was screened in 12 subsets segregated by ORF length. Ten months after transplantation the recipient mice were euthanized and DNA from mammary gland tumors was harvested. No tumors formed in mice transplanted with cells into which a control virus had been transduced. Genes from the library that were expressed in the tumors were identified by sequencing. The ability of these genes to drive tumor formation was confirmed by transduction and transplantation into a second cohort of mice. One of the genes identified in this screen is GTF2I repeat domain containing 1 (GTF2IRD1). Multi-focal atypical hyperplasia formed in mammary glands over-expressing GTF2IRD1 while no hyperplasia was seen in the control mice. This effect depends on the expression of ErbB2 because expression of GTF2IRD1 itself in wild type mammary glands did not cause abnormal growth before the end point. Analysis of the cancer genome atlas database demonstrates that GTF2IRD1 expression is significantly increased in invasive breast cancer compared to normal controls. Therefore, our screen has identified a novel tumor-promoting gene that is of potential clinical importance. A major advantage of our method is the use of normal cells of origin and immunocompetent mice. Moreover, it could be expanded to genome-wide searches for new tumor- and metastasis-promoting genes. Citation Format: Yongliang Huo, Ian Macara. In vivo screen for novel breast cancer promoting genes. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-42. doi:10.1158/1538-7445.AM2013-LB-42
Sex Differences in Secondary Attack Rate of IDDM to Siblings of Probands Through Older Ages: Pittsburgh Etiology of IDDM Study
Authors: Jeffrey A Gavard, Janics S Dorman, Ronald E LaPorte, Trevor J Orchard, Allan L Drash, Massimo M Trucco, Sheryl F Kelsey, Jill N Kostraba, Dorothy J Becker
Journal: Diabetes Care (1992)

To determine the descriptive epidemiological patterns of the secondary attack rate of insulin-dependent diabetes mellitus (IDDM) among siblings of probands through older ages.A family history analysis was performed on 1774 IDDM probands who were diagnosed or seen within 1 yr of diagnosis at Children's Hospital of Pittsburgh from 1 January 1950 through 31 December 1981. The probands were discharged on insulin and were diagnosed at less than 17 yr of age. The time frame permitted the risk of IDDM for siblings of probands to be calculated over a broad spectrum of age.Risk estimates for the 3966 full natural siblings through 10, 20, and 30 yr of age were 1.6, 4.1, and 6.3%, respectively. Secondary attack rates were equivalent for male and female siblings through 15 yr of age (3%); however, the risk to males increased an additional 4% between 16 and 30 yr of age compared with 2.5% for females (P = 0.01). There was no evidence of an excess sex concordance among affected sibling pairs.Males have a greater secondary attack rate of IDDM at older ages than females. This may be due to an increased exposure to environmental agents among males or protective influences operating among females.
Opium in Infancy and Adult Life.
Authors: Giffard Knox
Journal: JAMA (1900)

Westfield, N. J., May 22, 1900. <h3>To the Editor:</h3> —I have read, with the greatest interest, the paper inThe Journalof May 19, entitled: "Use of Opium in Infancy, seen in Adult Life," by Dr. T. D. Crothers. It is, in many respects, one of the most striking contributions to current literature that has been recently published, and although a year has passed since the occasion of the Doctor's reading it, it touches the chord of perennial importance. I have not had all the experience that Dr. Crothers has had, for I am not a specialist in his line, but in the course of practice among children in both New York and Brooklyn, from 1888 to the present year, I have been privileged to corroborate and confirm all that he has said, and very much more. The use of opium in infancy and childhood is an evil of the
Evidence of HLA Linkage in Depressive Disorders
Authors: Steven Matthysse, Kenneth K. Kidd
Journal: New England Journal of Medicine (1981)

IN this issue, Weitkamp et al.1 report major progress in understanding the genetics of depressive disorders (also called affective disorders). They have found that depressive disorders segregate along with HLA in families, which strongly suggests that a locus on the sixth chromosome, close to the HLA region (but not necessarily part of it) contributes substantially to the risk of depressive disorders.The first report of linkage between HLA and affective disorders was written by Smeraldi et al. in 1978.2 His group found that pairs of siblings, both of whom had affective disorders, shared HLA haplotypes more often than would be . . .
Hyperchloremic Acidosis and Diabetic Ketoacidosis
Authors: ARTHUR H. FISHER
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 April 1979Hyperchloremic Acidosis and Diabetic KetoacidosisARTHUR H. FISHER, M.D.ARTHUR H. FISHER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-4-722_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Oh and colleagues in the December issue (1) described 35 patients who developed hyperchloremic acidosis during treatment of diabetic (normochloremic) ketoacidosis. In their discussion of the pathogenetic mechanisms involved, they did not consider a renal tubular defect as a contributing cause of the hyperchloremic acidosis. Serum and total body phosphate levels are known to be severely depressed during the early treatment phase of diabetic ketoacidosis (2, 3), and phosphate depletion has been associated with renal bicarbonate wasting and systemic hyperchloremic metabolic acidosis (3, 4).It is unfortunate that serum phosphate and urinary pH determinations were not recorded...References1. OHCARROLLGOLDSTEINFEIN MHDI: Hyperchloremic acidosis during the recovery phase of diabetic ketosis. Ann Intern Med 89:925-927, 1978 LinkGoogle Scholar2. KANTERGERSONBESSMAN YJA: 2,3-Diphosphoglycerate, nucleotide phosphate, and organic and inorganic phosphate levels during the early phases of diabetic ketoacidosis. Diabetes 26:429-433, 1977 CrossrefMedlineGoogle Scholar3. KNOCHEL J: Hypophosphatemia. Clin Nephrol 7:131-137, 1977 MedlineGoogle Scholar4. GOLDMASSRYARIEFFCOBURN LGAJ: Renal bicarbonate wasting during phosphate depletion. A possible cause of altered acid base homeostasis in hyperparathyroidism. J Clin Invest 52:2556-2562, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Queens Hospital Center Affiliation Long Island Jewish-Hillside Medical Center Queens, NY 11432 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRenal Acidification Defect in Diabetic KetoacidosisCHARLES C. BAILEY JR., M.D., ROBERT W. STEINER, M.D. 1 April 1979Volume 90, Issue 4Page: 722-723KeywordsAcidosisBicarbonatesPathogensPhosphates Issue Published: 1 April 1979 PDF DownloadLoading ...