tbuckley/cabot-search huggingface dataset:
THE ETIOLOGY OF INCRUSTED CYSTITIS WITH ALKALINE URINE
Authors: BENJAMIN H. HAGER
Journal: JAMA (1925)

Incrusted cystitis is a chronic inflammatory condition of the urinary bladder manifested clinically by symptoms of dysuria, urgency and frequency, and the passage of gritty material or sand. In certain cases the urine is strongly alkaline, the degree depending somewhat on the severity and chronicity of the process. Usually the urine contains a large amount of blood and mucus, and sometimes pus. The marked discrepancy between the number of red blood corpuscles and pus cells in the urine in this form of cystitis has often been contrasted with the ratio in ordinary cystitis. Because of the nature of the gritty material and the alkaline condition of the urine, this particular type of cystitis has been referred to as chronic alkaline phosphatic cystitis. On cystoscopic examination the bladder presents crusted material which is hard, is firmly embedded in the mucous membrane, and may be limited, affecting only a small area of
Health Care Insurance: The Basics
Authors: Janet M. Torpy, Alison E. Burke, Richard M. Glass
Journal: JAMA (2007)

Health Care Insurance: The Basics T o cope with the potentially high costs of medical care, insurance policies provide some financial protection.Many individuals with insurance are covered under an employer-based plan (options offered and partially funded by their employer).Individual health insurance coverage, though more costly, can be obtained through some companies.Uninsured persons depend on their own ability to pay, qualifying for government insurance, or the care that physicians and institutions donate to those unable to pay.The March 14, 2007, issue of JAMA is a theme issue on access to health care.
THE EFFECT OF ALDOSTERONE, CORTISOL, AND CORTICOSTERONE UPON THE SODIUM AND POTASSIUM CONTENT OF SHEEP'S PAROTID SALIVA*
Authors: J. R. Blair-West, J. P. Coghlan, D. A. Denton, J. R. Goding, R. D. Wright
Journal: Journal of Clinical Investigation (1963)

Aldosterone diacetateCyclohexane-benzene-methanol-water 100:50:100:25 Adrenosterone Cyclohexane-dioxane-methanol-water 100:75:50:25 1 1-Keto-17a-OH-progesterone Aldosterone 11,18-lac-Cyclohexane-benzene-methanol-water 100:75:100:30 11-Keto-17a
Carboplatin and Renal Function
Authors: Egbert F. Smit
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 June 1989Carboplatin and Renal FunctionEgbert F. Smit, MD, Dirk Th. Sleijfer, MD, Sijtze Meijer, MD, Nanno H. Mulder, Pieter E. Postmus, MDEgbert F. Smit, MDSearch for more papers by this author, Dirk Th. Sleijfer, MDSearch for more papers by this author, Sijtze Meijer, MDSearch for more papers by this author, Nanno H. MulderSearch for more papers by this author, Pieter E. Postmus, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-12-1034_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Reed and Jacob (1) report on renal toxicity following high-dose carboplatin (800 mg/m2 body surface) in patients pretreated with cisplatin who have refractory ovarian cancer. A substantial decrease in creatinine clearance was seen in three patients. In nine other patients who received vigorous intravenous hydration no reductions in creatinine clearance occurred. Mulder and colleagues (2) reported a case history of a patient who developed renal failure after a cumulative dose of carboplatin of 750 mg/m2 in 3 days. This patient was also pretreated with a regimen containing cisplatin. However, carboplatin has also proved to be nephrotoxic...References1. ReedJacob EJ. Carboplatin and renal dysfunction [Letter]. Ann Intern Med. 1989;110:409. LinkGoogle Scholar2. MulderSleijferde VriesUgesMulder PDEDN. Renal dysfunction following high-dose carboplatin treatment. J Cancer Res Clin Oncol. 1988;114:212-4. CrossrefMedlineGoogle Scholar3. GoreCalvertSmith MAI. High-dose carboplatin in the treatment of lung cancer and mesothelioma: a phase I dose escalation study. Eur J Cancer Clin Oncol. 1987;23:1391-7. CrossrefMedlineGoogle Scholar4. SleijferSmitMeijerMulderPostmus DESNP. Acute and cumulative effects of carboplatin on renal function. Br J Cancer. [In press]. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University Hospital Groningen Groningen The Netherlands PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPoliquimioterapia secuencial (carboplatino/vp-16) versus alternante (carboplatino/vp-16 y ciclofosfamida/vincristina/adriamicina) en el carcinoma microcítico de pulmónDrug-Induced NephropathiesClinical trial and pharmacokinetics of carboplatin 560 mg/m2 in children 15 June 1989Volume 110, Issue 12Page: 1034-1034KeywordsCreatinineOvarian cancerRenal cancerRenal failureToxicity Issue Published: 15 June 1989 PDF DownloadLoading ...
Abstract LB-182: Effects of methyl donor status on intestinal tumorigenesis in ApcMin/+ mice
Authors: Krishna Kadaveru, Petr Protiva, Emily J. Greenspan, Young-In Kim, Daniel W. Rosenberg
Journal: Cancer Research (2012)

Abstract The goal of the present study is to determine the effects of folate deficiency on intestinal tumorigenesis in ApcMin/+ mice, a widely used animal model for human familial adenomatous polyposis (FAP). Since folate plays an important role in maintaining methyl donor status, dietary folate levels were reduced in combination with a panel of methyl donors, including choline, methionine and vitamin B12. Although the impact of folate on colorectal cancer (CRC) has been studied extensively, its role in cancer chemoprevention remains controversial. For example, folate supplementation has been widely discussed as a strategy for lowering cancer incidence. However, excess folate has also been associated with increased cancer risk. The following studies were designed to evaluate the effects of folate deficiency on intestinal tumorigenesis in ApcMin/+ mice. In Study 1, methyl donor sufficient diet (MDS) and methyl donor deficient diet (MDD) were fed to mice, beginning at either 5 or 10 weeks of age. Intestinal tumors were evaluated at 16 weeks of age. MDD diet suppressed intestinal tumor formation in ApcMin/+ mice by ∼80% when started at 5 weeks of age. Importantly, the protective effect was lost when the MDD diet was started at 10 weeks of age, indicating an important time-dependency on cancer suppression. Gene expression profiling of normal colonic mucosa after 11 weeks on MDD diet identified the most significantly down-regulated genes related to immune response and inflammation, data that are consistent with a recently published human colon expression profiling study (Protiva et al., 2011). The cancer suppression, however, was associated with reduced food intake and lowered body weight gain (up to 40%) throughout the experimental period. To control for this effect, Study 2 was performed in which ApcMin/+ mice were pair-fed with either methyl donor sufficient (MDS) or methyl donor deficient (MDD) diet, beginning at 5 weeks of age for a total of 11 weeks. A third group received MDS ad libitum. At 16 weeks of age, intestinal tumor formation was significantly reduced (54%, p&amp;lt;0.001) in the caloric-restricted MDS group. In the MDD group, however, tumor suppression was almost complete (∼96%, p&amp;lt;0.001). Associated with tumor protection were increased numbers of apoptotic cells within the villous epithelium of the small intestine, with a concomitant reduction in cell proliferation assessed by Ki-67 and Phospho-histone H3 (pHH3). While cancer protection by methyl donor deficiency is partially dependent on reduced caloric intake, additional mechanisms dependent on altered cell turnover must be invoked to explain these results. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-182. doi:1538-7445.AM2012-LB-182
Synovial fluid Waaler-Rose and latex tests.
Authors: E C Huskisson, F D Hart, B W Lacey
Journal: Annals of the Rheumatic Diseases (1971)

Positive serum Waaler-Rose and Latex tests provide a useful confirmation of the clinical diagnosis of rheumatoid arthritis, but a significant number of patients remain persistently negative.Positive synovial fluid tests were reported in a few sero- negative patients by Rodnan, Eisenbeis, and Creighton (1962), who suggested that this might be useful in diagnosis.We have reviewed all the Waaler- Rose and latex tests carried out on synovial fluid at this hospital in the last 6 years, with a view to assessing their value in diagnosis.
US health reform law will cost less than projected, says budget office
Authors: M. McCarthy
Journal: BMJ (2015)

In this study, we analyze the performance persistence of hedge funds over short- and long-term horizons. Using a non-parametric test, we first observe that the Relative Value and the Specialist Credit strategies contain the highest proportion of outperforming managers. We next analyze the performance persistence of portfolios ranked according to their average past returns. Persistence is mainly observed over one- to three-month holding periods but rapidly vanishes as the formation or the holding period is lengthened. We finally examine long-term risk-adjusted returns persistence of hedge fund portfolio within an APT framework. This leads us to detect a slight overreaction pattern that is more pronounced among the directional hedge fund strategies.
Down with EBM!
Authors: N. Molesworth
Journal: BMJ (1998)

We Molesworths hav a noble and distinkuished history of investigating the intrikacies of science. So I hav bin watching the hole evidence-based medicin thing with intrest and it is clere that it is turning into a bunfight. Some say all EBM-ers are arrogant controvershal and seducitve. Others say they are parasites and alkemists. Also many hav beards (my observashun). This is called evidence. Others say: we do not lik all this meat analysis, giv us more bad old reviews the wors the better. All this is simlar to when Peason and Fothering-Tomas call each other names: you hav a face like a squashed tomato no but you are a gurly … all wizard fun, but it is not conjusive to helping new ticks appreshiate what is EBM and how you do it. So it is my plesur to giv you an objecktive insite into the sordid world of EBM and it's practises.

From my detaled critikle apraisal it apears there …
Patterns of hospital medical staffing.
Authors: A. Carney
Journal: BMJ (1992)

Many of these associations with microalbuminuria are even more pronounced in the presence of overt proteinuria,4 " 23 which predicts a much greater risk of death from coronary heart disease in diabetic and hypertensive patients and in the general population.2"26In patients with insulin dependent diabetes mellitus overt proteinuria may be present, however, in fewer than half of those with established coronary heart disease.27Microalbuminuria may also be a non-specific marker for acute illness2" (including myocardial infarction), when it may be operating as an acute phase reactant, and of malignancy, when it probably reflects a microvascular response to tumour related mediators.29In these circumstances microalbuminuria could have a prognostic value in reflecting the severity of the acute illness or response to treatment.Microalbuminuria is uncommon without established cardiovascular disease or other cardiovascular risk factors.Screening for microalbuminuria currently seems justified in diabetic and hypertensive patients, and possibly in elderly patients, as it seems to identify those at greatest risk of premature death.Microalbuminuria and the subsequent excess risk of nephropathy and cardiovascular disease may be amenable to correction in diabetic patients.Whether similar gains are possible in elderly patients with microalbuminuria and patients with essential hypertension remains to be seen, but in such cases consideration might be given to more active management of hypertension.
Dobutamine-induced recovery of asynergy improves the abnormal signal averaged ECG after myocardial infarction
Authors: Maria-Aurora Morales, Ezio-Maria Ferdeghini, Antonio Fazi, Marcello Piacenti, Celio Gremigni, Gualtiero Pelosi, Rossano Vergassola, Antonio L'Abbate
Journal: Journal of the American College of Cardiology (1996)
The association between contact sensitization and atopic disease by linkage of a clinical database and a nationwide patient registry
Authors: J. P. Thyssen, J. D. Johansen, A. Linneberg, T. Menné, K. Engkilde
Journal: Allergy (2012)

Abstract Background Experimental studies have shown that individuals with atopic dermatitis are likely to have suppressed contact sensitivity secondary to their disease whereas some clinical and epidemiological studies have shown that individuals with atopic dermatitis might have a higher prevalence of contact sensitization than controls. The objective was to study the association between contact sensitization and, respectively, atopic dermatitis and asthma using clinical databases. Methods Record linkage of two different registers was performed: (i) a tertiary hospital register of dermatitis patient's patch tested for contact sensitivity and (ii) the Danish National Patient Register containing nationwide hospital discharge diagnoses and outpatient contacts. Results An inverse association was found between contact sensitization and, respectively, presumed severe atopic dermatitis ( OR , 0.70; 95% CI , 0.61–0.81) and asthma ( OR , 0.61; 95% CI , 0.42–0.90) when linkage was performed. Inverse associations were found for all groups of chemicals and metals except for sensitization to fragrances and topical drugs where positive associations were identified. A significant positive association between fragrance sensitization and presumed mild–moderate atopic dermatitis was also found when data from hospital register only were used, suggesting an overall higher prevalence of fragrance sensitization in patients with atopic dermatitis. Conclusions Our findings support that patients with severe atopic dermatitis and asthma have an overall lower prevalence of contact sensitization when compared with controls, whereas mild‐to‐moderate disease does not suppress contact sensitization. The prevalence of contact sensitization to fragrance chemicals was higher in patients with atopic dermatitis. Patients should be instructed to avoid scented moisturizers and products containing highly sensitizing substances.
IDENTIFICATION OF JUMPING ACTIVITY IN VOLLEYBALL BY USING ACCELEROMETER
Authors: KM Mok, JM Jarning, BH Hansen, R Bahr
Journal: British Journal of Sports Medicine (2014)

Background In volleyball, training and match exposure is a risk factor for developing patellar tendinopathy which is known as jumper's knee. The frequency of jumping is an indicator of the intensity of jumping activity in training and match. Accelerometer provides measure of time-variant vertical acceleration which can potentially be transformed to the frequency of jumping activity. However, the ability of identifying jumping activity from other volleyball specific activity is unknown. Objective To investigate the feasibility of using accelerometer to identify jumping activity from non-jumping activity in volleyball. Design A methodological study. Setting Subjects performed 7 different volleyball specific activities including non-jumping (side stepping, diving and sprinting) and jumping (float serving, block jumping, jump serving and spike jumping). The time-variant vertical acceleration was recorded by a hip-worn accelerometer (ActiGraph GT3X+) with 100Hz sampling rate. Participants Male elite volleyball players in national level (n=12). Risk factor assessment Not applicable. Main outcome measurements The peak vertical acceleration of activities was extracted from the time-variant vertical acceleration data. One way ANOVA was run to assess whether the peak vertical acceleration differentiated by activity. Post-hoc analyses were carried out using pairwise comparisons with alpha (0.05) adjusted using the Bonferroni correction. Results Not all the peak vertical accelerations for jumping activities were significantly different from those for non-jumping activities (table 1). Moreover, the variation of peak vertical acceleration between subjects was large. Table 1. Results from ANOVA with post-hoc Bonferroni on peak vertical acceleration (g). Jumping activity Float serving Block jumping Jumping serving Spike jumping Non-jumping activity Side steping NS p&lt;0.01 p&lt;0.01 p&lt;0.01 Sprinting NS NS NS p&lt;0.01 Diving p&lt;0.01 NS NS NS NS: No significant difference found. Conclusions Based on the measure of peak vertical acceleration from accelerometer, the non-jumping and jumping activity in volleyball cannot be distinguished. An alternative approach is needed for applying accelerometers to measure the frequency of jumping in volleyball .
Looking at the pictures.
Authors: T Delamothe
Journal: BMJ (1990)

endeavours must be better than one that waits until we perform badly and then punishes (or even retrains) us.Furthermore, quality is a banner that all are willing to rally round.Despite these attractions health workers have been even slower than Western industry to come to kaizen.Partly this is because health workers are unused to learning from business.Another problem is that doctors "have difficulty seeing themselves as participants in processes, rather than as lone agents of success or failure."2R Jaffe (personal communication) has identified three broad reasons why doctors have difficulties with kaizen: failures of vision include doctors defining quality narrowly as medical decision making, and thinking (wrongly) that better quality must mean higher expenditure; many doctors are uncomfortable with systematic analysis of data; and implementation may be difficult because doctors are too used to controlling others.Doctors also lack a leadership determined, in the words of Ford, to make quality "job number one," and all the quality gurus agree that nothing works without a strong commitment from an organisation's leaders.Doctors need those leaders.
Blockade of CCR4 in a humanized model of asthma reveals a critical role for DC‐derived CCL17 and CCL22 in attracting Th2 cells and inducing airway inflammation
Authors: F. Perros, H. C. Hoogsteden, A. J. Coyle, B. N. Lambrecht, H. Hammad
Journal: Allergy (2009)

Background: As Th2 type lymphocytes orchestrate the cardinal features of allergic asthma, inhibiting their recruitment to the lungs could be of therapeutic benefit. Although human Th2 cells express the CCR4 chemokine receptor and increased production of CCR4 ligands has been found in asthmatic airways, studies in animals have reached contradictory conclusions on whether blocking this pathway would be beneficial. Objective: As a lack of efficacy might be due to differences between mouse and man, we readdressed this question using a humanized severe combined immunodeficiency model of asthma. Methods: Mice received peripheral blood mononuclear cells from house dust mite (HDM) allergic asthmatic patients and then underwent bronchial challenge with HDM. Results: This resulted in marked allergic inflammation and bronchial hyper‐reactivity. Administration of CCR4 blocking antibody abolished the airway eosinophilia, goblet cell hyperplasia, IgE synthesis and bronchial hyperreactivity. In this chimeric system, human CD11c+ dendritic cells (DCs) were the predominant source of CCR4 ligands, suggesting that DC‐derived chemokines attract Th2 cells. In separate experiments using human DCs, in vitro exposure to HDM of DCs from HDM allergic patients but not healthy controls caused CCL17 and CCL22 release that resulted in chemoattraction of polarized human Th2 cells in a CCR4‐dependent way. Conclusions: Taken together, our data provide proof of concept that CCR4 blockade inhibits the salient features of asthma and justify further clinical development of CCR4 antagonists for this disease.
Value of Endoscopic Ultrasonography in the Detection of Anomalous Connections of the Pancreatobiliary Duct
Authors: M. Mitake, S. Nakazawa, Y. Naitoh, E. Kimoto, Y. Tsukamoto, K. Yamao, K. Inui
Journal: Endoscopy (1991)

Endoscopic ultrasonography (EUS) was evaluated in the detection of anomalous connection of the pancreatobiliary duct (ACPBD), which is known to cause cholangitis and has been found to be associated with cholangiocarcinoma. Fourteen patients with ACPBD were examined preoperatively by EUS in addition to ERCP and/or PTC. In all cases, the anomalous connections between the biliary and pancreatic duct were demonstrated to be located outside the proper muscle of the duodenal wall and within the pancreatic parenchyma. EUS classification of ACPBD corresponded well with the findings obtained by retrograde ductal opacification on ERCP and PTC. Biliary malignancy complicating ACPBD was detected correctly by EUS in two patients. In contrast, no connections between biliary and pancreatic ducts were found by EUS in 13 normal controls. It is concluded that EUS is highly sensitive in detecting ductal anomaly in ACPBD. Further studies will show if EUS can replace ERCP in the diagnosis of ACPBD.
Sports injuries--their prevention and treatment
Authors: Henry E. Robson
Journal: British Journal of Sports Medicine (1986)

This is an excellent book, not only on sports injuries but also on training, biomechanics and failures that lead to injury, on sport for the disabled, and the young, and an excellent last chapter giving in detail with photographs the exercises needed for rehabilitation.The anatomical diagrams illustrating various injuries are excellent, though a few errors in labelling have been allowed to creep in; in the figure on page 354 labelling of the talus and calcaneum have been reversed; on page 387 the trachea is labelled 'oesophagus' and on page 410 the label for the insertion of the iliopsoas is pointing to the upper third of the sartorius.We cannot blame the authors for these, nor for some uncorrected spelling mistakes, -'kilopond', not 'kilopound'l