tbuckley/cabot-search huggingface dataset:
The p90 RSK Family Members: Common Functions and Isoform Specificity
Authors: Romain Lara, Michael J. Seckl, Olivier E. Pardo
Journal: Cancer Research (2013)

The p90 ribosomal S6 kinases (RSK) are implicated in various cellular processes, including cell proliferation, survival, migration, and invasion. In cancer, RSKs modulate cell transformation, tumorigenesis, and metastasis. Indeed, changes in the expression of RSK isoforms have been reported in several malignancies, including breast, prostate, and lung cancers. Four RSK isoforms have been identified in humans on the basis of their high degree of sequence homology. Although this similarity suggests some functional redundancy between these proteins, an increasing body of evidence supports the existence of isoform-based specificity among RSKs in mediating particular cellular processes. This review briefly presents the similarities between RSK family members before focusing on the specific function of each of the isoforms and their involvement in cancer progression.
Prognostic significance of ventricular premature depolarizations measured 1 year after myocardial infraction in patient with early postinfarction asymptomatic ventricular arrhythmia
Authors: Alfred P. Hallstrom, J.Thomas Bigger, Dan Roden, Lawrence Friedman, Toshio Akiyama, David W. Richardson, William J. Rogers, Albert L. Waldo, Craig M. Pratt, Robert J. Capone, Lawrence Griffith, Pierre A. Theroux, Allan H. Barker, Raymond L. Woosley
Journal: Journal of the American College of Cardiology (1992)
Antimicrobial Treatment in Diabetic Women with Asymptomatic Bacteriuria
Authors: Godfrey K.M. Harding, George G. Zhanel, Lindsay E. Nicolle, Mary Cheang
Journal: New England Journal of Medicine (2002)

Asymptomatic bacteriuria is common among women with diabetes, and the treatment of such infections has been recommended to prevent complications related to symptomatic urinary tract infection.
89 Risk of early atherosclerosis evaluated by carotid artery intima-media thickness in patients with non-alcoholic fatty liver disease: A case control study
Authors: A.L. Fracanzani, L. Burdick, S. Rasselli, P. Pedotti, L. Grigore, G. Santorelli, L. Valenti, A. Maraschi, A. Catapano, S. Fargion
Journal: Journal of Hepatology (2006)
Major liver resection induces a similar decrease in the fischer ratioas in hepatic encephalopathy which improves by administration ofbactericidal/permeability-increasing protein (rBPI21)
Authors: R.J. Nijveldt, M.J. Wiezer, C. Meijer, D.J. Gouma, T.M. van Gulik, I.H.M. Borel Rinkes, H.W. Tilanus, C.J.S. van de Velde, T. Wiggers, F.A.N. Zoetmulder, M.A. Cuesta, S. Meijer, P.A.M. van Leeuwen
Journal: Journal of Hepatology (2000)
Absence of the Fallopian Tubes and of Menstruation, Associated with Recurrent Peritonitis: (A Second Case)
Authors: W. G. Spencer
Journal: BMJ (1911)

IMENDICAL JOUIRNAL 6. Whilst its chief indication will be found during the frst stage of labour, the fear of rapid delivery following its use is not a contraindication.In conclusion, we wish to thank the Master, Dr. Hastings T weedy, for
Ethics and the Medical Record
Authors: Timothy J. Drehmer, Mary T. White, Barbara L. Schuster
Journal: Annals of Internal Medicine (2002)

Letters3 December 2002Ethics and the Medical RecordTimothy J. Drehmer, MD, Mary White, PhD, and Barbara L. Schuster, MDTimothy J. Drehmer, MDWright State University School of Medicine; Dayton, OH 45435Search for more papers by this author, Mary White, PhDWright State University School of Medicine; Dayton, OH 45435Search for more papers by this author, and Barbara L. Schuster, MDWright State University School of Medicine; Dayton, OH 45435Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-11-200212030-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We wholeheartedly support Dr. Tauber's concern for improving patient care and the physician–patient relationship [1]. However, we believe his proposal for a separate section in the medical record for ethical issues is problematic. Our chief objection is that virtually every aspect of clinical medicine is replete with ethical implications. Relegating selected ethical issues to a separate section in the medical record could easily encourage a minimalist view of ethics. Rather than trying to increase ethical sensitivity through requiring separate documentation, we believe this goal can be attained only by making systemic changes in medical education and by ...References1. Tauber AI. Putting ethics into the medical record. Ann Intern Med. 2002;136:559-63. [PMID: 11926802] LinkGoogle Scholar2. Bissonette R, O'Shea RM, Horwitz M, Route’ CF. A data-generated basis for med-ical ethics education: categorizing issues experienced by students during clinical train-ing. Acad Med. 1995;70:1035-7. [PMID: 7575932] CrossrefMedlineGoogle Scholar3. Goldie J. Review of ethics curricula in undergraduate medical education. Med Educ. 2000;34:108-19. [PMID: 10652063] CrossrefMedlineGoogle Scholar4. Savulescu J, Crisp R, Fulford KW, Hope T. Evaluating ethics competence in med-ical education. J Med Ethics. 1999;25:367-74. [PMID: 10536759] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Timothy J. Drehmer, MD; Mary White, PhD; Barbara L. Schuster, MDAffiliations: Wright State University School of Medicine; Dayton, OH 45435 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPutting Ethics into the Medical Record Alfred I. Tauber Ethics and the Medical Record Fritz Baumgartner Ethics and the Medical Record Alfred I. Tauber Metrics 3 December 2002Volume 137, Issue 11Page: 932-933KeywordsMedical educationMedical ethicsMotivationPatientsResidencyUndergraduates ePublished: 3 December 2002 Issue Published: 3 December 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Best wishes for your incurable illness
Authors: Trisha Greenhalgh
Journal: BMJ (2007)

“Get well soon” is a greeting from a bygone era, in which illness was generally acute and self limiting. These days, those of us on the shady side of 40 are as likely as not to have at least one disease that will not go away, and those over 65 have an average of three. A rising stack of policy documents seeking to address the needs of people who are never going to get better emphasises self efficacy, concordance, expert patienthood, peer support, …
SKIN SCRAPINGS IN LEPROSY
Authors: H. W. Wade
Journal: JAMA (1952)

<h3>To the Editor:—</h3> The clinical note inThe Journal, Jan. 5, page 44, by Dr. R. K. Maddock, entitled: "Skin Scrapings in Leprosy; Positive Results by the Wayson Technique in Eighty-Four Supposedly Arrested Cases," is, I fear, likely to cause some confusion in the literature. Leprosy workers who see the title will wish to learn of this supposedly improved technique of obtaining material for bacteriological smears. Actually it is the long-established and widely-used "scraped-incision" method, with nothing new except the insistence that the cut be made through the full thickness of the skin; and the advantage of that, if any, is offset by the facts that, apparently, the incision is scraped only once and only one lesion or lesion-site is examined. Dr. Maddock referred to the technique he described as the "snip" method. That method, however, long used in certain quarters, involves removal of a shallow piece of the skin
Human Coronary Arteriolar Dilation to Bradykinin Depends on Membrane Hyperpolarization
Authors: Hiroto Miura, Yanping Liu, David D. Gutterman
Journal: Circulation (1999)

Background —K + channel activation in vascular smooth muscle cells (VSMCs) plays a key role in regulating vascular tone. It has been proposed that endothelium-derived hyperpolarizing factor (EDHF) contributes to microvascular dilation more than nitric oxide (NO) does. Whether hyperpolarization is important for coronary arteriolar dilation in humans is not known. Bradykinin (BK), an endogenous vasoactive substance, is released from ischemic myocardium and regulates coronary resistance. Therefore, we tested the effects of inhibiting NO synthase, cyclooxygenase, and K + channels on the changes in diameter and membrane potential (Em) in response to BK in isolated human coronary microvessels. Methods and Results —Arterioles (97±4 μm; n=120) dissected from human right atrial appendages (n=78) were cannulated at a distending pressure of 60 mm Hg and zero flow. Changes in vessel diameter (video microscopy) and VSMC Em (glass microelectrodes) were measured simultaneously. In vessels constricted and depolarized (Em; −50±3 to −28±2 mV) with endothelin-1 (ET), dilation to BK was associated with greater membrane hyperpolarization (−48±3 mV at 10 −6 mol/L) than dilation to sodium nitroprusside (SNP) (−34±2 mV at 10 −4 mol/L) for similar degrees of dilation. Treatment with N ω -nitro- l -arginine methyl ester (L-NAME; 10 −4 mol/L), an NO synthase inhibitor, partially decreased dilation to BK (maximum dilation 61±10% versus control 92±4%; P &lt;0.05). Charybdotoxin (CTX; 10 −8 mol/L), a large-conductance Ca 2+ -activated K + channel blocker, or apamin (10 −7 mol/L), a small-conductance Ca 2+ -activated K + channel blocker, inhibited both dilation (CTX 22±6% and apamin 45±10% versus control 69±6%; P &lt;0.05) and membrane hyperpolarization (CTX −31±2 mV and apamin −37±2 mV versus control –44±2 mV; P &lt;0.05) to BK, whereas glibenclamide (10 −6 mol/L), an ATP-sensitive K + channel blocker, was without effect. Conclusions —Vasodilation of human coronary arterioles to BK is largely dependent on membrane hyperpolarization by Ca 2+ -activated K + channel activation, with apparently less of a role for endothelium-derived NO. This suggests a role for K + channel activation in regulating human coronary arteriolar tone.
Mycoplasma, Amnionitis, and Respiratory Distress Syndrome
Authors: Philip A. Brunell
Journal: JAMA (1969)

<i>Mycoplasma hominis</i>type 1 was isolated from amniotic fluid obtained at cesarean section. Section was performed three days following rupture of the membranes in an effort to salvage an infant from a mother in whom puerperal sepsis had developed. Other organisms could not be recovered from the amniotic fluid specimen nor could bacteria be isolated from the mother's blood. Respiratory distress syndrome developed in the infant and he died. On pathological examination the lungs revealed evidence of interstitial pneumonia. No bacteria or hyaline membranes were seen.
Family Practice Education
Authors: Beuford T. Durmon
Journal: JAMA (1983)

To the Editor.—  Jacob F. Palomaki, MD, from Cleveland responded (1982; 248:2971) to Dr Hinnen's article inThe Journal(1982;248:590) and has stimulated my desire to propose another solution to the problem of family practice education.  It seems to me that family practice educators find themselves in conflict with specialty services for all the wrong reasons. We share concern for quality of training, yet disagree in part about the definition of quality. Both groups feel that what they have to teach is of sufficient importance to justify full-time commitment on the part of the residents. Both groups are basically right. What must be remembered is that the ultimate goal is to have these residents become competent family physicians . Residents need a confidence that their present and future role is worthwhile. Dr Palomaki apparently desires to disunite medicine (the first 18 months) and family medicine (the second 18 months).  Currently, we
Studies of the Satiety Response in Mice1
Authors: Guy Hollifield, William Parson
Journal: Journal of Clinical Investigation (1957)

The increase in general activity which follows food deprivation in animals is well known (1).Less well known is the marked decrease in spon- taneous running activity which occurs after a pe- riod of refeeding.Working with rats, Finger (2) demonstrated that after a period of food depriva- tion, feeding produced a marked decrease in spon- taneous running activity as measured by the re- volving cage technique.He called this response a "satiation syndrome."Studies in this laboratory (3) have confirmed this satiety response in mice.The present study was designed to determine some of the factors involved in this response. METHODS AND MATERIALSFemale mice of the DBA strain obtained from the Jackson Memorial Laboratories, Bar Harbor, Maine, were used in this study.These mice were housed at constant temperature (72 F.), relative humidity (48 per cent), and with 12 hours of light each day.Mice under active study were placed in revolving activity cages modi- fied from those described by Richter and Wang (4).
Viruses Inducing Cancer: Implications for Therapy
Authors: R. M. Mulligan
Journal: JAMA (1966)

This symposium on tumor viruses, with 30 papers and 80 participants, is divided into two main parts. Part 1, covering viral infection and tumors, takes up murine leukemia, avian leukosis and related neoplasms, mammary tumors, induction of tumors and transformation of cells by deoxyribonucleic acid viruses, molecular structure of adenovirus, and virus-specific complement-fixing neoantigens in virus-free but virus-induced tumor cells. Part 2 concerns the diagnosis and management of viral infections, including virus detection, cell-bound and humoral cytotoxic antibodies in tumor immunity, prophylaxis, and therapy. Some of the topics dealt with are immunologic relationships among some of the murine leukemia viruses, virus-host interactions of avian tumors, immunology of spontaneous mammary carcinoma in mice, immunization against tumors induced by human adenovirus, comparative molecular structure of oncogenic and nononcogenic adenoviruses, and detection of oncogenic viral infections by the fluorescent antibody technique. Of special interest are the papers on electron microscopic structure of Newcastle
ADDRESS ON AN EXHIBIT OF EARLY (PRIOR TO 1860) BRITISH AND AMERICAN OPHTHALMIC LITERATURE.
Authors: CASEY A. WOOD
Journal: JAMA (1902)

At the outset let me say that the books, pamphlets, atlases, portraits and other illustrations of the early history of ophthalmology in this country and Great Britain are almost entirely derived from the private collections of the members of the committee. In addition to these we are equally indebted to the kindness of Dr. Dennett, librarian of the New York Eye and Ear Infirmary, for a copy of the first annual report, by-laws and other interesting matter relating to the oldest of our ophthalmic hospitals. Little or no notice is taken of the numerous monographs (about one-tenth of the whole) on cataract, since Dr. A. A. Hubbell, one of the members of our committee, will address you on that important subject. Particular attention is invited to the library and other relics in this exhibit of Dr. George Frick, which we are able to present through Dr. Harry Friedenwald, by the
Still Life With Flowers, Shells, a Shark's Head, and Petrifications
Authors: M. Therese Southgate
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Points from Letters: Making Hospital Geriatrics Work
Authors: J. H. Mitchell
Journal: BMJ (1974)

poem.I was particularly interested as there is a current neglect of medals as a source of medical history.May I make some observations on the medal itself?The object under the lancet on the reverse is a vaccine point, perhaps of ivory, on which the material, fresh or dry, would be conveyed to the scarified area.Ampoules were not used for biological material until sterilization was understood.Incidentally, the goddess has a bandage round her left arm as though she had been recently vaccinated, surely a work of supererogation. . Schonlein versus Henoch
Insensitivity to Digoxin Associated with Hypocalcemia
Authors: Deepak Chopra, Paul Janson, Clark T. Sawin
Journal: New England Journal of Medicine (1977)

Hypercalcemia increases the effect of digitalis and its derivatives on the heart. Hypocalcemia, on the other hand, is not a recognized inhibitor of the action of digitalis, although resistance to the action of digitalis is known to occur in a variety of conditions such as anemia, hyperthyroidism, rheumatic carditis or subacute bacterial endocarditis.1 , 2 In the hypocalcemic patient described below, atrial fibrillation associated with a rapid ventricular response failed to respond to therapeutic levels of digoxin until the serum calcium had risen toward the normal range.Case ReportAn 85-year-old man was admitted to the hospital complaining of shortness of breath. . . .
Cost-Related Nonadherence to Medications Among Patients With Diabetes and Chronic Pain
Authors: Jacob E. Kurlander, Eve A. Kerr, Sarah Krein, Michele Heisler, John D. Piette
Journal: Diabetes Care (2009)

OBJECTIVE In the face of financial constraints, diabetic patients may forgo prescribed medications, causing negative health effects. This study examined how cost and noncost factors are associated with patterns of cost-related nonadherence to medications (CRN). RESEARCH DESIGN AND METHODS This was a cross-sectional survey of patients using medications for both diabetes and chronic pain (n = 245). Patients reported their income, out-of-pocket medication costs, education level, depressive symptoms, and medication-related beliefs and whether they cut back because of cost on 1) both diabetes and pain medications, 2) diabetes medications only, 3) pain medications only, or 4) neither. Multinomial logistic regression was used to model patients' adjusted odds ratios (AORs) of falling into these four possible categories. RESULTS Of the patients, 9% cut back on medications for both conditions, 13% cut back on diabetes medications alone, and 9% cut back on pain medications alone. Income &amp;lt;20,000 USD (AOR = 5.7, P = 0.008) and monthly medication costs &amp;gt;50 USD (AOR = 3.9, P = 0.02) increased patients' odds of CRN for both conditions versus neither. Low-income patients also were more likely to selectively forgo pain medications (AOR = 9.1, P = 0.001) but not diabetes medications (AOR = 2.1, P = 0.12). More depressive symptoms (AOR = 1.6, P = 0.006) and negative medication-related beliefs (AOR = 1.7, P = 0.02) increased patients' odds of cutting back selectively on medications for diabetes but not pain. CONCLUSIONS Patients who forgo medications for both diabetes and chronic pain appear to be influenced primarily by economic pressures, whereas patients who cut back selectively on their diabetes treatments are influenced by their mood and medication beliefs. Our findings point toward more targeted strategies to assist diabetic patients who experience CRN.
Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice
Authors: Odochi Ohia-Nwoko, Saghi Montazari, Yuen-Sum Lau, Jason L Eriksen
Journal: Molecular Neurodegeneration (2014)

Recent epidemiological evidence suggests that modifying lifestyle by increasing physical activity could be a non-pharmacological approach to improving symptoms and slowing disease progression in Alzheimer's disease and other tauopathies. Previous studies have shown that exercise reduces tau hyperphosphorylation, however, it is not known whether exercise reduces the accumulation of soluble or insoluble tau aggregates and neurofibrillary tangles, which are both neuropathological hallmarks of neurodegenerative tauopathy. In this study, 7-month old P301S tau transgenic mice were subjected to 12-weeks of forced treadmill exercise and evaluated for effects on motor function and tau pathology at 10 months of age. Exercise improved general locomotor and exploratory activity and resulted in significant reductions in full-length and hyperphosphorylated tau in the spinal cord and hippocampus as well as a reduction in sarkosyl-insoluble AT8-tau in the spinal cord. Exercise did not attenuate significant neuron loss in the hippocampus or cortex. Key proteins involved in autophagy—microtubule-associated protein 1A/1B light chain 3 and p62/sequestosome 1 —were also measured to assess whether autophagy is implicated in the exercised-induced reduction of aggregated tau protein. There were no significant effects of forced treadmill exercise on autophagy protein levels in P301S mice. Our results suggest that forced treadmill exercise differently affects the brain and spinal cord of aged P301S tau mice, with greater benefits observed in the spinal cord versus the brain. Our work adds to the growing body of evidence that exercise is beneficial in tauopathy, however these benefits may be more limited at later stages of disease.
Cancer of the Lung
Authors: Carlos A. Perez
Journal: JAMA (1976)

This is a review of many aspects of lung cancer in which the authors have attempted to summarize the present state of knowledge on the subject. As in any book prepared with this general purpose, some of the chapters are more comprehensive than others. A succinct discussion of the historical events, incidence, and etiology of lung cancer is presented, without a great deal of depth or detail. The chapter on pathology is one of the best, including some rare tumors such as mixed and mesenchymal tumors. The chapters on natural history and lymphatic spread of cancer of the lung are particularly illustrative and contain a great deal of information that should be helpful in attempting to develop therapeutic strategies to manage these patients. The diagnostic radiology aspects of bronchogenic carcinoma are dealt with in extreme detail, although, unfortunately, because of the nature of the tumor, the definition of these characteristics
Pakistan lags behind in reproductive health
Authors: C. Wallerstein
Journal: BMJ (1998)

This article focuses on Pakistan's slowness in shifting values to improve the health of women from birth until death. Girls experience 66% higher death as children aged under 4 years than boys. Large segments of Pakistani society still value males and consider daughters to be a "shameful burden." The lessons learned from the 1994 Cairo Conference on Population and Development reveal that Pakistan will suffer socioeconomic decline by ignoring the need to change traditional male and religious attitudes. Pakistan was criticized for neglecting preventive health care and education and for spending less on social welfare than smaller neighbors, such as Bhutan and Nepal. 1 in 38 women dies during childbirth or pregnancy; the regional average is 1/230. Literacy is 26% for women and 50% for men. Almost 25% of children are born underweight. Infant mortality is 95/1000 live births; child mortality is 136/1000 live births. 45% of the population still do not have access to any form of health service. The health budget is largely spent on curative treatment instead of IEC campaigns which are potentially more effective over the long term. Field workers experience mistrust and constraints from religious leaders and matriarchs in their efforts to spread use of contraception among younger women. There are beginning to be signs of change at the grassroots level.