tbuckley/cabot-search huggingface dataset:
Progressive Soft Tissue Uptake of Tc-99m MDP Reflecting Metastatic Microcalcification
Authors: ROBIN D. LOW, RODNEY J. HICKS, L BARRY ARKLES, GARY GILL, WILLIAM ADAM
Journal: Clinical Nuclear Medicine (1992)

A 49-year-old woman had longstanding renal impairment. Markedly increased uptake of Tc-99m MDP in the heart, lungs, and kidneys was an incidental finding on bone scintigraphy performed to exclude metastatic bone disease. These findings persisted on repeat bone imaging 1 year later. In addition, gastric and skeletal muscle uptake was subsequently seen. Soft tissue microcalcification was confirmed by computed tomography and renal biopsy. A consideration of the differential diagnosis is presented.
Down-regulation of RAG1 and RAG2 gene expression in PreB cells after functional immunoglobulin heavy chain rearrangement
Authors: Ulf Grawunder, Thomas M.J. Leu, David G. Schatz, Annick Werner, Antonius G. Rolink, Fritz Melchers, Thomas H. Winkler
Journal: Immunity (1995)

Two waves of immunoglobulin gene rearrangements, first of the heavy, then of the light chain chain gene loci form functional immunoglobulin genes during B cell development. In mouse bone marrow the differential surface expression of B220 (CD45R), c-kit, CD25, and surrogate light chain as well as the cell cycle status allows FACS separation of the cells in which these two waves of rearrangements occur. The gene products of two recombination activating genes, RAG1 and RAG2 are crucial for this rearrangement process. Here, we show that the expression of the RAG genes is twice up- and down-regulated, at the transcriptional level for RAG1 and RAG2, and at the postranscriptional level for RAG2 protein. Expression levels are high in D-->JH and VH-->DJH rearranging proB and preB-I cells, low in preB cells expressing the preB cell receptor on the cell surface, and high again in VL-->JL rearranging small preB-II cells. In immature B cells expressing on the cell surface RAG1 and RAG2 mRNA is down-regulated, whereas RAG2 protein levels are maintained. Down-regulation of RAG1 and RAG2 gene expression after productive rearrangement at one heavy chain allele might be part of the mechanisms that prevent further rearrangements at the other allele.
Childhood Diabetes and Intensive Insulin Therapy
Authors: Errol C. Baptist
Journal: JAMA (1983)

<h3>To the Editor.—</h3> The article by Geffner et al<sup>1</sup>stressed the importance of self-monitoring of blood glucose levels and intensified insulin administration in achieving improved glycemic control. However, I wish to take issue with the impression created that multiple insulin injections daily were mandatory in attaining this goal. In my own pediatric diabetic population, there exists a group of patients whose conditions are well controlled with single daily injections of combined intermediate- and short-acting insulin. These patients have had the following characteristics: (1) nonbrittle diabetes, (2) well-motivated and well-informed parents, (3) carefully planned diets, (4) frequent home blood glucose monitoring, (5) regular glycosylated hemoglobin assays, and (6) close physician supervision. Additional doses of regular insulin are occasionally required as indicated by the blood glucose values. Multiple doses of insulin daily can be a traumatic experience to the parent and child, especially in the 1- to 5-year age group. If
Reporting of conflicts of interest from drug trials in Cochrane reviews: cross sectional study
Authors: M. Roseman, E. H. Turner, J. Lexchin, J. C. Coyne, L. A. Bero, B. D. Thombs
Journal: BMJ (2012)

<b>Objectives</b> To investigate the degree to which Cochrane reviews of drug interventions published in 2010 reported conflicts of interest from included trials and, among reviews that reported this information, where it was located in the review documents. <b>Design</b> Cross sectional study. <b>Data sources</b><i>Cochrane Database of Systematic Reviews</i>. <b>Selection criteria</b> Systematic reviews of drug interventions published in 2010 in the <i>Cochrane Database of Systematic Reviews</i>, with review content classified as up to date in 2008 or later and with results from one or more randomised controlled trials. <b>Results</b> Of 151 included Cochrane reviews, 46 (30%, 95% confidence interval 24% to 38%) reported information on the funding sources of included trials, including 30 (20%, 14% to 27%) that reported information on trial funding for all included trials and 16 (11%, 7% to 17%) that reported for some, but not all, trials. Only 16 of the 151 Cochrane reviews (11%, 7% to 17%) provided any information on trial author-industry financial ties or trial author-industry employment. Information on trial funding and trial author-industry ties was reported in one to seven locations within each review, with no consistent reporting location observed. <b>Conclusions</b> Most Cochrane reviews of drug trials published in 2010 did not provide information on trial funding sources or trial author-industry financial ties or employment. When this information was reported, location of reporting was inconsistent across reviews.
Dr Wright replies
Authors: W. Gordon
Journal: Cardiovascular Research (1992)

Dr Wright replies Get access Wright Gordon Wright Gordon Department of Biological Sciences University of Keele Staffordshire United Kingdom Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 3, March 1992, Pages 302–303, https://doi.org/10.1093/cvr/26.3.302 Published: 01 March 1992
On Writing (6): Writing a Book
Authors: J. Baillie, C. Kotlar
Journal: Endoscopy (2005)

For those struggling with their first meeting abstract or journal manuscript, writing a textbook must seem like climbing Mount Everest. Agreed, book writing is not for the faint-hearted, and like marriage, should not be undertaken lightly. Why would one write a book? Fame, perhaps? Certainly, it is a way to disseminate your name and establish a reputation as an expert or authority in your field (provided the book lives up to expectations!). Having a book (or two) in your curriculum vitae (resume) doesn’t do any harm when the promotions committee reviews your work. Some people write because they feel that they have ”a book in (them)”. If you have a bookful of thoughts and experiences to share on a particular topic, good for you - go for it! A word of caution, however, for anyone who thinks textbook writing is financially lucrative: it’s not! Authors of textbooks see relatively little return on the typically huge investment of time and effort. Indeed, there are ”invisible” costs of major writing projects, such as the evenings and weekends you sacrifice to the great god Word Processor (and take away from friends and family). Unless you are a very boring individual with no social life to speak of, you will certainly give up a lot of recreation time to work on your masterpiece. It’s a good idea before starting out to write a textbook to talk to someone who has done this already. And you should declare your intention to your spouse or ”significant other”!
SEVERE INFECTIONS WITH THE VIRUS OF LYMPHOCYTIC CHORIOMENINGITIS
Authors: John P. Colmore
Journal: JAMA (1952)

In 1933, during the St. Louis encephalitis epidemic, Armstrong and Lillie 1 isolated a virus which in rhesus monkeys always caused a round cell infiltration of the meninges and choroid plexus and which they therefore named lymphocytic choriomeningitis virus. Since the demonstration of virus neutralizing and complement fixing antibodies in the serums of persons convalescing from infections with the virus of lymphocytic choriomeningitis, it has been estimated that 11% of the general population in urban areas have antibodies against this virus without any history of clinical infection. 2 The syndrome of benign lymphocytic choriomeningitis characterized by an initial grippal syndrome of 3 to 10 days' duration, followed in a week to 10 days by symptoms of meningeal irritation, with about a thousand white blood cells in the spinal fluid, of which 90% to 100% are lymphocytes, with negative results of bacteriological studies on the spinal fluid, and with uncomplicated recovery
Pathogenesis of Arrhythmias Associated with Metastatic Tumors of the Heart
Authors: Thomas N. James, G. M. Carrera
Journal: New England Journal of Medicine (1959)

THE clinical bases of ante-mortem diagnosis of tumors of the heart are discussed in several excellent reviews.1 2 3 That such a diagnosis is sometimes of more than academic significance is proved by increasingly frequent reports of successful surgical removal of certain cardiac tumors.4 5 6 One of the clinical bases for diagnosis of a cardiac tumor is the occurrence of otherwise unexplained arrhythmias that are refractory to usual therapy and vary in type. If these events occur in a patient known to have a primary malignant lesion, the likelihood of cardiac metastasis increases. This is especially true of tumors that are known to . . .
Expression of high mobility group protein 1 in the sera of patients and mice with systemic lupus erythematosus
Authors: W Jiang, D S Pisetsky
Journal: Annals of the Rheumatic Diseases (2007)

High mobility group protein 1 (HMGB1) is a non-histone nuclear protein with a dual function. Inside the cell, HMGB1 binds to DNA and modulates a variety of processes, including transcription. Outside the cell, HMGB1 can serve as an alarmin to mediate disease manifestations in animal models of sepsis and arthritis; in these models, blocking HMGB1 can attenuate disease.1–3

In in vitro experiments, HMGB1 translocation and cellular release can occur during activation as well as cell death and is present in tissue in conditions, such as rheumatoid arthritis and cutaneous lupus.4 5 While original studies suggested that release occurs only with necrosis, …
The use of BDNF to enhance the patency rate of small-diameter tissue-engineered blood vessels through stem cell homing mechanisms
Authors: Wen Zeng, Can Wen, Yangxiao Wu, Li Li, Zhenhua Zhou, Jianhong Mi, Wen Chen, Mingcan Yang, Chunli Hou, Jiansen Sun, Chuhong Zhu
Journal: Biomaterials (2011)
Quantitation of human immunodeficiency virus, immune activation factors, and quinolinic acid in AIDS brains.
Authors: C L Achim, M P Heyes, C A Wiley
Journal: Journal of Clinical Investigation (1993)

HIV encephalitis is unusual in that neurologic damage occurs in the absence of significant infection of neuronal or glial cells. Because the predominant infected cell in the brain is the macrophage, it has been proposed that release of viral or immune activation factors from macrophages may mediate neurologic damage. Numerous studies have examined the concentration of immune activation factors in the cerebrospinal fluid (CSF), however, there has been no correlation between these CSF measurements and severity of HIV encephalitis (Wiley, C.A., C.L. Achim, R.D. Schrier, M.P. Heyes, J.A. McCutchen, and I. Grant. 1992. AIDS (Phila.). 6:1299-1307. Because CSF measurements may not represent tissue concentrations of these factors, we examined the concentrations of HIV p24, quinolinic acid (QUIN), IL-1, IL-3, IL-6, TNF-alpha, and GMCSF within the brains of 10 AIDS autopsies. Homogenization and extraction of cortical gray, cortical white and deep gray matter showed a good correlation between the amount of HIV gp41 immunostaining and extracted HIV gag protein p24. The concentrations of cytokines were low in the tissue extracts and showed no correlation with severity of HIV encephalitis. Brain extracts from mild cases of HIV encephalitis showed elevated levels of TNF-alpha in deep gray matter, while in more severe cases, elevated TNF-alpha levels were also found within cortical white and cortical gray matter. Brain tissue and CSF QUIN concentrations were substantially increased compared to control values. QUIN concentrations were not correlated with the severity of HIV encephalitis. We conclude that increased tissue levels of TNF-alpha and QUIN may have a role in the etiology of HIV-related neurologic dysfunction.
Chronic Severe Periorbital Edema
Authors: Richard Weleber
Journal: JAMA (1976)

<h3>To the Editor.—</h3> The 25-year-old man cited by Stanley Marcus, MD (235:2019, 1976) as having chronic recurrent bilateral periorbital edema since 5 years of age may indeed have true blepharochalosis,<sup>1</sup>an autosomal dominant condition in which recurrent temporary lid swelling leads to loose folds of violaceous, somewhat atrophic eyelid skin. The recurring attacks of edema often cause attenuation and disinsertion of the levator aponeurosis from the upper tarsus, resulting in ptosis. Moderate or large levator resections by conventional techniques, without regard for the fact that the muscle is intact and of normal strength, will often result in severe overcorrection of the ptosis. Lid surgery should be directed at reinsertion of the levator aponeurosis in a controlled fashion under local anesthesia, as advocated by Drs Jones and Wobig.<sup>2</sup>
Mesothelioma and Local Immunotherapy
Authors: SABURO SONE
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 April 1978Mesothelioma and Local ImmunotherapySABURO SONE, M.D., EIRO TSUBURA, M.D.SABURO SONE, M.D.Search for more papers by this author, EIRO TSUBURA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-4-575_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We have read "Pleural Mesothelioma: Clinical Features and Therapeutic Implications" by Legha and Muggia (1) with interest. Recently, successful pleural injection of BCG or BCG cell-wall skeleton (BCG-CWS) was reported in the treatment of minimal residual tumor after pulmonary resection for lung cancer (2) and metastatic cancer to pleural cavity (3). The treatment of diffuse pleural mesothelioma presents problems, but local immunotherapy with intrapleural injection of bacterial preparations seems to be a hopeful therapeutic procedure. Direct contact of bacterial antigens and mesothelioma cells can be expected to have an antitumor effect because the mesothelioma cells tend to...References1. LEGHAMUGGIA SF: Pleural mesothelioma: clinical features and therapeutic implications. Ann Intern Med 87:613-621, 1977 LinkGoogle Scholar2. MCKNEALLYMAVERKAUSEL MCH: Regional immunotherapy of lung cancer with intrapleural B.C.G. Lancet 1:377-379, 1976 CrossrefMedlineGoogle Scholar3. YAMAMURAOGURAYOSHIMOTONISHIKAWASAKATANIITOHMASUNONAMBAYAZAKIHARAOAZUMA YTTHMMTMHFI: Successful treatment of the patients with malignant pleural effusion with BCG cell-wall skeleton. Gann 67:669-677, 1976 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SABURO SONE, M.D.; EIRO TSUBURA, M.D.Affiliations: Tokushima University Hospital Tokushima 770 Japan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChemotherapy in malignant mesothelioma: a reviewTreatment of diffuse pleural malignant mesothelioma by cis dichloro diammine platinum (C.D.D.P.) in nine patients 1 April 1978Volume 88, Issue 4Page: 575-575KeywordsAntigensBacille calmette guerinCancer treatmentCellsLung and intrathoracic tumorsLung resectionMesotheliomaRespiratory system proceduresSkeletonTumor resection ePublished: 1 December 2008 Issue Published: 1 April 1978 PDF downloadLoading ...
Patient centred approach may help in hypertension
Authors: T. Lewis
Journal: BMJ (2003)

EDITOR—Benson and Britten examined why patients choose to take drug treatment for hypertension and expose the ambivalence some people feel about pharmaceutical intervention for chronic disease.1 We have recently completed a study looking at the reasons a notable proportion of diagnosed hypertensive patients does not return for follow up appointments.

We identified 35 such non-returners in populations from three general practices in Worcester, Droitwich, and Exmouth (approximately 5% of the hypertension registers). Eleven of these patients (age …
Molecular Therapy: The Journal of the American Society of Gene Therapy | Gene Function and Disease
Authors: Andrea Amalfitano, Eric D. Albright
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recurrent Cellulitis After Bypass Surgery Associated With Psoriasis
Authors: Thomas M. File
Journal: JAMA (1984)

<h3>To the Editor.—</h3> In the recent article, "Recurrent Cellulitis After Coronary Bypass Surgery: Association With Superficial Fungal Infection in Saphenous Venectomy Limbs," Baddour and Bisno<sup>1</sup>speculate that the pathogenesis of this syndrome may involve complex interactions between fungal and bacterial agents since the majority of their patients (seven of nine) had tinea infection. We would like to add that in the last two years we have seen two additional patients with this syndrome. One patient (a 51-year-old man with six recurrent episodes of cellulitis within two years of coronary artery bypass graft [CABG] surgery) had tinea infection. However, the second patient (a 60-year-old man with cellulitis in the venectomy site 50 months after CABG surgery) did not have tinea infection but rather had psoriasis involving the dorsal aspect of his foot just distal to the area of cellulitis. Like Baddour and Bisno, we were unable to isolate bacteria from
Reports of pancreatitis are 20-30 times more likely with GLP-1 drugs, analysis finds
Authors: D. Cohen
Journal: BMJ (2013)

A class of antidiabetes drugs is associated with an increase in safety alerts for pancreatitis and pancreatic cancer, a new analysis has found.

The Institute for Safe Medication Practices, a US non-profit organisation that promotes the safe use of drugs, monitored reports of serious adverse events to the US Food and Drug Administration from 1 July 2011 to 30 June 2012 concerning five glucagon-like peptide-1 (GLP-1) based agents (exenatide, liraglutide, sitagliptin, saxagliptin, and linagliptin) used to lower blood glucose concentrations. 

It compared these against the rates of adverse event reporting for a control group of drugs comprising other drugs used to treat type 2 diabetes (three sulfonylureas and metformin) and drugs for treating other diseases.

GLP-1 …
An Olympic legacy for couch potatoes?
Authors: Mary E Black
Journal: BMJ (2012)

I am happily imbued with Olympic spirit. Enthralled, uplifted, and privileged to have been in London this summer. I was involved, as many others were, in the NHS planning, I met a few athletes, and I even managed to get tickets to some events. The television coverage was great, the 70 000 volunteers (4100 in the medical teams alone) were outstanding, and London showed its best face. Despite the gloom mongering the Central Line ran better than usual, and total strangers conversed on the tube. We succeeded in a global effort that is much more …
Single Dose Ivabradine versus Metoprolol for Heart Rate Reduction Before Coronary Computed Tomography Angiography (CCTA): In Patients Who Were Receiving Calcium Channel Blocker Therapy
Authors: Ömer Çelik, Mehmet Mahir Atasoy, Mehmet Ertük, Hale Ünal Aksu, Ahmet Arif Yalçın, Ibrahım Faruk Aktürk, Mustafa Diker, Işıl Atasoy
Journal: Journal of the American College of Cardiology (2013)
Clinical Aspects of Aging
Authors: Robert L. Kane
Journal: JAMA (1989)

The editor of this volume remarks in his preface to this edition that he hopes this book will reflect "progress in the evolution of what is special about the aged person and the care of the elderly." The changes since the previous edition in 1983 tell us a good deal about what has happened in geriatric care and suggest some things that remain to be done. This is a very revised new edition. Most of the authors are new; many of the choices reflect Dr Reichel's move to Georgetown University's School of Medicine (Washington, DC). Whole areas of emphasis have been added, and these additions reflect geriatrics' recent emphases. Chapters on functional assessment and drug therapy are strong. A chapter is given over to health maintenance, but the conclusions must rely on weak data. Incontinence receives special attention as a subchapter. Alcohol and other drug dependency is highlighted, as is
Lung function response of healthy women after sequential exposures to NO2 and O3.
Authors: M J Hazucha, L J Folinsbee, E Seal, P A Bromberg
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Since NOx emissions bear a precursor-product relation with ambient ozone (O3) levels, the sequence of peak ambient concentrations is first nitrogen dioxide (NO2) followed later in the day by ozone (O3). We ascertained whether preliminary exposure to 0.6 parts per million (ppm) NO2 would affect the lung function response to subsequent exposure to 0.3 ppm O3. Twenty-one healthy young nonsmoking women (18 to 35 yr of age) underwent two sets of exposures on two different days separated by a minimum of 2 wk. On one day, subjects were exposed to air for 2 h followed 3 h later by a 2-h exposure to O3. On the other day, the first exposure was to NO2; order of the days was randomized. During each exposure subjects intermittently exercised, alternating 15 min of rest with 15 min of exercise (Ve approximately 40 L/min). Spirometry was performed before the first exposure and at 1-h intervals until the end of the 2-h (O3) exposure. Plethysmography measurements were made before and after NO2 and O3 exposures. Nonspecific airway reactivity (AR) was determined at least 1 wk prior to the first exposure and following each O3 exposure. AR to methacholine (MCh) was expressed as dose required to decrease FEV1 by 10% (PD10FEV1). Nitrogen dioxide exposure alone did not reduce FEV1 but did significantly enhance O3-induced spirometric changes. No significant effects were observed in plethysmography. On both exposure days, the median PD10FEV1 was significantly reduced (p < 0.05) from control PD10FEV1 (14.3 mg/ml).(ABSTRACT TRUNCATED AT 250 WORDS)
567 MODULATION OF HUMAN HEPATIC STELLATE CELLS (HSCS) BEHAVIOUR BY HEPATITIS B VIRUS (HBV) X PROTEIN (HBX) THROUGH TRANSFORMING GROWTH FACTOR BETA SIGNALLING PATHWAY
Authors: S. Martin-Vilchez, Y. Rodriguez-Muñoz, P. Sanz-Cameno, M. Lopez-Cabrera, R. Moreno-Otero, E. Lara-Pezzi
Journal: Journal of Hepatology (2008)