tbuckley/cabot-search huggingface dataset:
Abstract 2703: Loss of dependence on EGFR signaling by upregulation of Mig6 confers drug resistance to erlotinib
Authors: Xiaofei Chang, Aditi Chatterjee, Shyhmin Huang, Myoung Sook Kim, Chunbo Shao, Constance L. Monitto, Patrick K. Ha, Manuel Hidalgo, Paul M. Harari, David M. Berman, Atul Bedi, David Sidransky
Journal: Cancer Research (2010)

Abstract We sought to elucidate mechanisms of resistance to epidermal growth factor receptor (EGFR)-targeted therapies and to identify markers that could better distinguish resistant from sensitive patients. Here we show that mitogen-inducible gene 6 (Mig6), a negative regulator of EGFR, was selectively upregulated during the evolution of resistance to the EGFR tyrosine kinase inhibitor (TKI) erlotinib in lung and head and neck cancer cell lines. Mig6 was a major determinant of EGFR activity in panels of cancer cell lines of different tissue origins, and in direct validation of approved human use, in a unique collection of directly xenografted human lung and pancreas tumors. Our work highlights the importance of cellular negative regulators of EGFR in predicting and subverting TKI responsiveness, and identifies the ratio of Mig6 to EGFR, rather than the absolute expression of either protein alone, to be a predictor of tumor cell response to erlotinib. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2703.
Siriraj stroke score and validation study to distinguish supratentorial intracerebral haemorrhage from infarction.
Authors: N Poungvarin, A Viriyavejakul, C Komontri
Journal: BMJ (1991)

To develop a simple, reliable, and safe diagnostic tool for acute stroke syndromes in a setting where computerised brain scanning was not readily available and to validate its accuracy with regard to pathological types of stroke.13 clinical variables that potentially might differentiate supratentorial cerebral haemorrhage from infarction were recorded and tested by multivariate analysis in a prospective study of 174 patients with acute stroke. In developing the Siriraj stroke score stepwise discriminant analysis of the variables was followed by a linear discriminant equation to differentiate between supratentorial haemorrhage and infarction. The score obtained was validated against scores in 206 other patients with stroke, computerised brain scans being used for definitive diagnosis.Siriraj Hospital Medical School, Mahidol University, Bangkok.Prospective study: 174 consecutive patients with acute supratentorial stroke syndrome (not subarachnoid haemorrhage) admitted to Siriraj Hospital during 1984-5; validation study: 206 patients admitted to Siriraj Hospital or another hospital for supratentorial intracerebral haemorrhage or infarction.The Siriraj stroke score was developed and calculated as (2.5 x level of consciousness) + (2 x vomiting) + (2 x headache) + (0.1 x diastolic blood pressure) - (3 x atheroma markers) - 12. A score above 1 indicates supratentorial intracerebral haemorrhage, while a score below -1 indicates infarction. The score between 1 and -1 represents an equivocal result needing a computerised brain scan or probability curve to verify the diagnosis. In the validation study of the Siriraj stroke score the diagnostic sensitivities of the score for cerebral haemorrhage and cerebral infarction were 89.3% and 93.2% respectively, with an overall predictive accuracy of 90.3%.The Siriraj stroke score is widely accepted and applied in hospitals throughout Thailand as a simple and reliable bedside method for diagnosing acute stroke.
WRITING THE DEATH CERTIFICATE
Authors: HAROLD B. WOOD
Journal: JAMA (1928)

Many defects appearing on death certificates would be readily corrected by a better understanding by physicians as to the requirements and uses of these records. The death certificate, next to the birth certificate, is the most important official record made of man. It is of the greatest importance, therefore, that this record be made accurate and complete. In the matter of inheritance and other legal matters, the family of the deceased deserve protection by a correct certificate. The public has a right to the help rendered from a statistical compilation of the death records. Once the certificates are bound they are not filed away to rest unmolested, as many persons suppose, but they are handled a great many times for various reasons. During 1927 the Pennsylvania Department of Health issued 34,325 certified copies of death certificates, or, copies of at least one-half the adult records among the 120,000 death certificates
Does Rigorous Quality Process Reporting Guarantee Superior-Quality Health Care?
Authors: Gary R. Seabrook
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bone Scintigraphy Pattern of Joint Chronic Graft-Versus-Host Disease After Allogeneic Bone Marrow Transplantation
Authors: Réka Zsigmond, Constantin Ungureanu, Oleg Blagosklonov, Ingrid Biancheri, Orland Angoué, Michel Runge, Daniel Wendling, Fabrice Larosa, Frédéric Paycha, Hatem Boulahdour
Journal: Clinical Nuclear Medicine (2008)

A 38-year-old man presented with an inflammatory polysynovitis involving the knees, ankles, hands, and shoulders, which appeared 1 year after bone marrow transplantation for chronic myeloid leukemia worsening. The diagnostic considerations included incipient iatrogenic or autoimmune inflammatory rheumatism, joint leukemia relapse, osteoarthritis, and joint chronic graft-versus-host disease (cGVHD). MRI appeared to be osteomyelitis. Radionuclide imaging suggested joint cGVHD diagnosis, which was confirmed by pathologic and microbiological studies, disclosing osteonecrosis but no rheumatoid, oncological, or infectious pattern. One-year follow-up showed clinical improvement under infliximab therapy and confirmed the diagnosis of joint cGVHD.
The future of cardiology and psychogeriatrics
Authors: R D Kennedy
Journal: BMJ (1981)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following The future of cardiology and psychogeriatrics Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Second language acquisition: Theoretical and experimental issues in contemporary research
Authors: Samuel David Epstein, Suzanne Flynn, Gita Martohardjono
Journal: Behavioral and Brain Sciences (1996)

Abstract To what extent, if any, does Universal Grammar (UG) constrain second language (L2) acquisition? This is not only an empirical question, but one which is currently investigable. In this context, L2 acquisition is emerging as an important new domain of psycholinguistic research. Three logical possibilities have been articulated regarding the role of UG in L2 acquisition: The first is the “no access” hypothesis that claims that no aspect of UG is available to the L2 learner. The second is the “partial access” hypothesis that claims that only LI instantiated principles and LI instantiated parameter-values of UG are available to the learner. The third, called the “full access” hypothesis, asserts that UG in its entirety constrains L2 acquisition. In this paper we argue that there is no compelling evidence to support either of the first two hypotheses. Moreover, we provide evidence concerning functional categories in L2 acquisition consistent with the claim that UG is fully available to the L2 learner (see also Flynn 1987; Li 1993; Martohardjono 1992; Schwartz &amp; Sprouse 1991; Thomas 1991; White 1989). In addition, we will attempt to clarify some of currently unclear theoretical issues that arise with respect to positing UG as an explanatory theory of L2 acquisition. We will also investigate in some detail certain crucial methodological questions involved in experimentally testing the role of UG in L2 acquisition and finally, we will present a set of experimental results of our own supporting the “Full Access” hypothesis.
The role of peroxynitrite in chemical preconditioning with 3-nitropropionic acid in rat hearts
Authors: N TURAN, C CSONKA, T CSONT, Z GIRICZ, G FODOR, P BENCSIK, M GYONGYOSI, I CAKICI, P FERDINANDY
Journal: Cardiovascular Research (2006)

3-Nitropropionic acid (3-NP), an irreversible inhibitor of succinate dehydrogenase, has been shown to protect against ischemic injury in the brain and in the heart via a preconditioning-like effect; however, the cellular mechanism is not known. The aim of the present study was to investigate if 3-NP pretreatment reduces infarct size and if altered metabolism of nitric oxide and reactive oxygen species are involved.Hearts were assigned into 3 groups: 3 intermittent cycles of 5 min no-flow ischemia separated by 5 min aerobic perfusion protocol were used to induce ischemic preconditioning as a positive control; a time-matched non-preconditioning group served as control; and 3-NP (20 mg/kg, i.p.) was injected 3 h before the perfusion protocol to induce pharmacological preconditioning. Hearts from all groups were then subjected to 30 min global ischemia followed by 120 min reperfusion.Infarct size and lactate dehydrogenase release were significantly reduced after ischemia/reperfusion. While cardiac nitric oxide (NO) was increased, superoxide formation, nitrotyrosine level, and cardiac NADH oxidase and xanthine oxidase (XO) activities were markedly reduced by 3-NP administration. Cardiac activities of NO synthase and superoxide dismutase were not changed by 3-NP.This is the first demonstration in the rat myocardium that 3-NP induces pharmacological preconditioning, thereby limiting infarct size, and that this effect is associated with increased NO bioavailability and reduced peroxynitrite formation due to inhibition of superoxide formation by XO and NADH oxidase.
A four-year prospective study of the work of the practice nurse in the treatment room of a South Yorkshire practice.
Authors: W H Waters, J M Sandeman, J E Lunn
Journal: BMJ (1980)

During a four-year study period 43 985 patients were seen in the treatment room and 61 806 coded procedures carried out. Thirty per cent of these procedures were not part of usual nursing curricula and required initial supervision and assessment or training (or both). Nearly 15% of the patients seen were making a first visit and did not require referral to a doctor. A further 17% were also making a first visit but were referred to a doctor. The treatment room made an important contribution to the work of the practice, but this would not have been possible if the staff concerned had been attached nurses requiring area health authority authorisation for procedures carried out as opposed to practice nurses for whom procedures were authorised on a personal basis.
Edward Huw Penry
Authors: H. Penry, R. Whittlesey
Journal: BMJ (2011)

After qualifying in 1967, Edward Huw Penry (“Huw”) spent three years in the National Health Service at St Mary’s Hospital Paddington, Salisbury, Norwich, and Bridgend. Then, having decided to spend some time abroad before joining his father’s general practice in Glamorgan, he went to Zambia in 1971 on a two year contract with Anglo American Corporation (AAC) (later Nchanga Consolidated Mines of Zambia) and stayed in Africa for 30 years, doing what he described as “providing a high standard of …
The Emerging Science of BMAA: Do Cyanobacteria Contribute to Neurodegenerative Disease?
Authors: Wendee Holtcamp
Journal: Environmental Health Perspectives (2012)

In the late 1990s ethnobotanist Paul Alan Cox visited the indigenous Chamorro people of Guam, sleuthing for cancer cures in the lush rainforest.He soon stumbled upon troubling facts that would change the trajectory of his career, leading to major clues in understanding Lou Gehrig's disease (amyotrophic lateral sclerosis, or ALS) and possibly other neuro degenerative diseases.Since that time, major breakthroughs in the fields of neurobiology, epidemiology, and ecology have led to an increased interest in an unlikely hypothesis: that β-methylamino-lalanine (BMAA)-a cyanobacterial neurotoxin found in contaminated seafood and shellfish, drinking water supplies, and recrea tional waters-may be a major factor in these diseases. A Trail of CluesThe trail of clues began soon after U.S. forces recaptured Guam from the Japanese in 1944.A Navy neurologist noticed the Chamorro people succumbed to a strange neurodegenerative illness that caused paralysis, shaking, and dementia at 50-100 times the incidence of ALS worldwide. 1,2The illness was dubbed amyotrophic lateral sclerosis-parkinsonism/dementia complex (ALS-PDC), known locally as lytico-bodig.Since then, neurologists have converged on the island to crack the medical version of the world's hardest math problem.Solving the mystery of this many-faceted illness, it was hoped, could unlock a deeper understanding of neuro degenerative diseases worldwide and possibly lead to a cure. Last fall, writer
Amelioration of Psoriasis by Anti-TNF-α RNAi in the Xenograft Transplantation Model
Authors: Maria Jakobsen, Karin Stenderup, Cecilia Rosada, Brian Moldt, Søren Kamp, Tomas N Dam, Thomas G Jensen, Jacob Giehm Mikkelsen
Journal: Molecular Therapy (2009)

Tumor necrosis factor-alpha (TNF-alpha) is upregulated in psoriatic skin and represents a prominent target in psoriasis treatment. The level of TNF-alpha-encoding mRNA, however, is not increased in psoriatic skin, and it remains unclear whether intervention strategies based on RNA interference (RNAi) are therapeutically relevant. To test this hypothesis the present study describes first the in vitro functional screening of a panel of short hairpin RNAs (shRNAs) targeting human TNF-alpha mRNA and, next, the transfer of the most potent TNF-alpha shRNA variant, as assessed in vitro, to human skin in the psoriasis xenograft transplantation model by the use of lentiviral vectors. TNF-alpha shRNA treatment leads to amelioration of the psoriasis phentotype in the model, as documented by reduced epidermal thickness, normalization of the skin morphology, and reduced levels of TNF-alpha mRNA as detected in skin biopsies 3 weeks after a single vector injection of lentiviral vectors encoding TNF-alpha shRNA. Our data show efficient lentiviral gene delivery to psoriatic skin and therapeutic applicability of anti-TNF-alpha shRNAs in human skin. These findings validate TNF-alpha mRNA as a target molecule for a potential persistent RNA-based treatment of psoriasis and establish the use of small RNA effectors as a novel platform for target validation in psoriasis and other skin disorders.
Sleeping Car Improvement.
Authors: Alfred Moore
Journal: JAMA (1904)

Memphis, Tenn., May 2, 1904. <h3>To the Editor:</h3> —Now that the Pullman Company intends making sanitary changes in their sleeping cars, might this not be an opportune time to advocate some change in the car structure, whereby sick and injured persons can be moved without so much inconvenience? At times patients have to undergo torture in being squeezed through the narrow and tortuous entrance of a sleeper, or else have to be hoisted up to and through a narrow window. This at times frightens a patient, and is not entirely without risk. I believe that with slight changes in the construction of a sleeper, all of this could be avoided, and would certainly add to the comfort and safety of patients.
Renal Hemodynamic Response to Vasopressor Agents in the Treatment of Shock
Authors: JOHN H. MOYER, GEORGE MORRIS, H. LISTON BEAZLEY
Journal: Circulation (1955)

Norepinephrine, when administered to normotensive subjects by continuous intravenous infusion produces a marked renal vasoconstriction and a reduction in renal blood flow. The opposite response is observed when this drug is given to patients in whom glomerular filtration rate and renal blood flow are already depressed due to shock. When the blood pressure in these patients is returned to normal with norepinephrine, there is an increase in both glomerular filtration rate and renal blood flow. There is also an increase in water and electrolyte excretion which is secondary to the increase in glomerular filtration rate.
Controversy Over Contraception Coverage—Reply
Authors: Dana R. Gossett, Jessica Kiley, Cassing Hammond
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): a randomised controlled superiority trial with a parallel HER2-negative cohort
Authors: Luca Gianni, Wolfgang Eiermann, Vladimir Semiglazov, Alexey Manikhas, Ana Lluch, Sergey Tjulandin, Milvia Zambetti, Federico Vazquez, Mikhail Byakhow, Mikhail Lichinitser, Miguel Angel Climent, Eva Ciruelos, Belén Ojeda, Mauro Mansutti, Alla Bozhok, Roberta Baronio, Andrea Feyereislova, Claire Barton, Pinuccia Valagussa, Jose Baselga
Journal: The Lancet (2010)
Mammographic Findings in Adenolipoma
Authors: Eugene A. Durso
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Adenolipoma is an unusual tumor of the breast. Some pathologists do not accept the diagnosis of this breast tumor. Geschickter,<sup>1</sup>Haagensen,<sup>2</sup>and Cutler<sup>3</sup>have described lipomas and adenolipomas and, in 1945, Spalding published a classical description of both tumors.<sup>4</sup>He described the tumor as a well-defined oval mass. "It is encapsulated, and its yellow surface is mottled by greyish-pink areas. Mottling is more marked in the center of the tumor than at the periphery." Microscopically, the tumor has the appearance of a lipoma with islands of epithelium embedded in the fat. This letter presents such a case with the roentgengraphic findings. <h3>Report of a Case.—</h3> A 22-year-old white woman complained of the lumps in both breasts, but physical examination failed to reveal specific masses. However, mammograms demonstrated a 10.0-cm mass, clearly encapsulated (Fig 1 and 2). The retromammary space was well demonstrated and not
An Optimistic and Aggressive Approach to the Treatment of Malignant Lymphoma
Authors: MYRON P. NOBLER
Journal: Annals of Internal Medicine (1968)

The laboratory, clinical, and technical evidence and achievements of the past 40 years have been briefly summarized as an approach to the rationale for the present aggressive, large-field, high-dose radiation treatment of the lymphomas, which is curative in intent. Although there are still a great many questions unanswered and there are still many patients who do not survive, the survival figures most recently obtained show a striking improvement and a magnificent gain for humanity in terms of the rescue or prolongation of many otherwise lost lives. It is our fervent hope that the improved treatment techniques discussed below, used alone or in combination with the newer chemotherapeutic agents, will show an even greater rewards in terms of preservation of human life and in dealing with this challenging and puzzling group of malignancies.
SOME OBSERVATIONS ON THE INTRACELLULAR LOCALIZATION OF THE VIRUS OF HERPES SIMPLEX IN THE CHICK EMBRYO LIVER
Authors: Alan Gray, T. F. McNair Scott
Journal: The Journal of Experimental Medicine (1954)

The growth cycle of the virus of herpes simplex in chick embryo liver has been shown to follow the same pattern as in the chorioallantoic membrane and the rabbit's corneal cells. However, there is considerable variability in the time taken for the yolk sac-inoculated virus to get from the yolk sac into the liver. A brief description has been given of various fractionation procedures employed for obtaining isolated nuclei. It has been shown that free virus is not selectively adsorbed to isolated nuclei. Evidence has been presented to show that in the herpes-infected chick embryo liver, large proportions of the total virus can at times be found associated with the nuclear fraction. The percentage of the total virus in the nuclear fraction varies inversely with the titer of virus in the whole liver, and the number of hours after inoculation of the virus; only a negligible amount (as compared with that in the total) being associated with the nuclear fraction when a period of over 12 hours has elapsed after reappearance of virus. Furthermore, demonstration of virus in the isolated nuclei following extraction with hypertonic NaCl provides additional evidence that this virus is intimately associated with the nuclei.
Chromosome aberrations in atypical chronic lymphocytic leukemia: a cytogenetic and interphase cytogenetic study
Authors: R Bigoni, A Cuneo, MG Roberti, A Bardi, GM Rigolin, N Piva, G Scapoli, R Spanedda, M Negrini, F Bullrich, ML Veronese, CM Croce, G Castoldi
Journal: Leukemia (1997)
Hero or villain?
Authors: T. Dalrymple
Journal: BMJ (2008)

Dr James Phillips Kay—or Dr James Phillips Kay-Shuttleworth, as he became after his marriage to an heiress—was one of the founding fathers of the British public health movement. He is mainly remembered nowadays, if he is remembered at all, for his pamphlet The Moral and Physical Condition of the Working Classes Employed in the Cotton Manufacture in Manchester , which was cited by Engels in his much more famous book on the condition of the English working class 12 years later, in 1844.

He qualified in Edinburgh in 1827, at the age of 23, and had the opportunity to put his skills into practice the next year when he was present …