tbuckley/cabot-search huggingface dataset:
Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas
Authors: Arkadiusz Piotrowski, Jing Xie, Ying F Liu, Andrzej B Poplawski, Alicia R Gomes, Piotr Madanecki, Chuanhua Fu, Michael R Crowley, David K Crossman, Linlea Armstrong, Dusica Babovic-Vuksanovic, Amanda Bergner, Jaishri O Blakeley, Andrea L Blumenthal, Molly S Daniels, Howard Feit, Kathy Gardner, Stephanie Hurst, Christine Kobelka, Chung Lee, Rebecca Nagy, Katherine A Rauen, John M Slopis, Pim Suwannarat, Judith A Westman, Andrea Zanko, Bruce R Korf, Ludwine M Messiaen
Journal: Nature Genetics (2013)
Cardiac-Resynchronization Therapy for Heart Failure
Authors: Joshua M. Hare
Journal: New England Journal of Medicine (2002)

The syndrome of congestive heart failure is responsible for substantial morbidity and mortality.1 Patients with heart failure have shortness of breath and a limited capacity for exercise, have high rates of hospitalization and rehospitalization, and die prematurely. The primary mode of therapy for this syndrome is based on antagonism of neurohormonal pathways (notably, the sympathetic nervous system2 and the renin–angiotensin–aldosterone axis3,4) activated in the failing cardiovascular system. Drugs that antagonize these pathways decrease mortality and morbidity24 and in some cases improve the underlying structural abnormalities of the heart, a process termed “reverse remodeling.”5 On the basis of . . .
ORGANIC ACID RATIO OF URINE AFTER TUBERCULIN
Authors: A. H. Gregson
Journal: BMJ (1913)

me, and I miade separate diagramiis whiclh were after- -wards comiipared with those of Dr. Batty Slhaw.Out of 19 eases there was stubstantial agreement in 17 cases, and minor differeances in 2, which wvere afterwards adjusted.ln some cases the extent of rlMes lhad increased, in somo retrogressed, and in otlhers remained stationary, wllile in still otlhers there had been increase of rlMes in one lung and dimiiinution in another.In such eases a balance lhad to be struck between the two, and the case adjudged as worse, statiolnary, or better accordingly.Phlysical signs were, therefore, taken as tlle mnain criterion, and alteration and increase of weiglht, ami-ount of excrcisc, aud general condition correlated secondarily.Choice of Cases.In agreCiiielm t with one of the safest recognlized miiethods of giving t-uberetuliln, it -was adopted as a sine quoi non that all the cases slhouldl be afebrile when up and abotut all dav, anid that rise of temperaturec maintained for more than a day or two slhotuld disqualify the patient from beinig one of the series.
Hindquarter Amputation
Authors: Grantley W. Taylor, William P. Rogers
Journal: New England Journal of Medicine (1953)

THE purpose of this paper is to describe some of the important aspects of an experience with 18 cases of malignant tumors treated by hindquarter amputation. No attempt is made to review the extensive literature or to reiterate all the details of the subject. For the sake of descriptive brevity, we prefer the term "hindquarter amputation"1 or "hemipelvectomy"2 to the numerous synonymous phrases that have been proposed for this procedure. It is recognized, however, that to literary purists, the term "hemipelvectomy" is not acceptable, being derived from both Greek and Latin components. Furthermore, we agree with Coley3 that these terms . . .
Psoriasis and cancer.
Authors: S Shuster, P H Chapman, M D Rawlins
Journal: BMJ (1979)

The incidence of skin cancer in patients with psoriasis seems to be low, despite repeated use of known carcinogens in treating the disorder. This may be due to a reduced capacity of psoriatic skin to metabolise precarcinogens because of impaired arylhydrocarbon hydroxylase (AHH) activity. If this hypothesis is correct, and impaired AHH activity in psoriatic skin is shared by other tissues, the incidence of cancers associated with environmental carcinogens may also be reduced in patients with psoriasis. Since the disease is probably genetically transmitted as a dominant trait, it may have persisted because it confers genetic advantage. This hypothesis, though speculative, provides a basis for further study.
Effect of tumor necrosis Factor-Alphaon endothelial and inducible nitric oxidesynthase messenger ribonucleic acidexpression and nitric oxide synthesisin ischemic and nonischemic isolated rat heart
Authors: Yosef Paz, Inna Frolkis, Dimitri Pevni, Itzhak Shapira, Yael Yuhas, Adrian Iaina, Yoram Wollman, Tamara Chernichovski, Nahum Nesher, Chaim Locker, Rephael Mohr, Gideon Uretzky
Journal: Journal of the American College of Cardiology (2003)
Risk Index for Postoperative Pneumonia
Authors: Ahsan M. Arozullah, Jennifer Daley
Journal: Annals of Internal Medicine (2002)

Letters1 October 2002Risk Index for Postoperative PneumoniaAhsan M. Arozullah, MD, MPH and Jennifer Daley, MDAhsan M. Arozullah, MD, MPHVeterans Affairs Chicago Healthcare System; University of Illinois College of Medicine; Chicago, IL 60612 (Arozullah)Tenet Health System; Dallas, TX 75240 (Daley)Search for more papers by this author and Jennifer Daley, MDVeterans Affairs Chicago Healthcare System; University of Illinois College of Medicine; Chicago, IL 60612 (Arozullah)Tenet Health System; Dallas, TX 75240 (Daley)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-7-200210010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:There are two distinct yet related goals during preoperative evaluation. The first is to accurately predict the risk for postoperative complications, and the second is to modify risk factors to reduce the risk for complications. The main purpose of our study was to contribute to accomplishing the first goal by developing and validating a risk index for predicting postoperative pneumonia using information that is readily available to clinicians before surgery. We purposely did not include potential risk factors, such as intraoperative blood loss or postoperative pain management, because this information is not typically available before surgery and is ...Reference1. Goldman L, Caldera DL, Nussbaum SR, Southwick FS, Krogstad D, Murray B, et al . Multifactorial index of cardiac risk in noncardiac surgical procedures. N Engl J Med. 1977;297:845-50. [PMID: 904659] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Ahsan M. Arozullah, MD, MPH; Jennifer Daley, MDAffiliations: Veterans Affairs Chicago Healthcare System; University of Illinois College of Medicine; Chicago, IL 60612 (Arozullah)Tenet Health System; Dallas, TX 75240 (Daley) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDevelopment and Validation of a Multifactorial Risk Index for Predicting Postoperative Pneumonia after Major Noncardiac Surgery Ahsan M. Arozullah , Shukri F. Khuri , William G. Henderson , Jennifer Daley , and Risk Index for Postoperative Pneumonia Avery Tung and Jerome M. Klafta Metrics 1 October 2002Volume 137, Issue 7Page: 620KeywordsBloodForecastingMedical risk factorsPain managementPneumoniaRisk assessmentsSurgery ePublished: 1 October 2002 Issue Published: 1 October 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
An Oasis in Time
Authors: Stanley Shi-Dan Liu
Journal: Annals of Internal Medicine (2010)

On Being a Doctor2 November 2010An Oasis in TimeStanley Shi-Dan Liu, MDStanley Shi-Dan Liu, MDFrom Johns Hopkins Bayview Medical Center, Baltimore, MD 21224.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-9-201011020-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail When I first started my intern year, my senior residents repeatedly told me that the Aliki rotation would be one of the best patient care experiences that I would ever have. The Aliki Initiative at the Johns Hopkins Bayview Medical Center is a unique inpatient wards rotation in which internal medicine residents manage one half of the usual patient census and play an increased role in patient care after discharge. Named after the philanthropist who funded it, the Aliki service is designed to help residents to better know their patients as individuals and to learn about issues related to transitions ... Author, Article, and Disclosure InformationAffiliations: From Johns Hopkins Bayview Medical Center, Baltimore, MD 21224.Corresponding Author: Stanley Shi-Dan Liu, MD, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAn Oasis in Time Michael E. Miller An Oasis in Time Lorraine Tosiello Metrics Cited byEffects of a Focused Patient-Centered Care Curriculum on the Experiences of Internal Medicine Residents and their PatientsAn Oasis in TimeMichael E. Miller, MDAn Oasis in TimeLorraine Tosiello, MD 2 November 2010Volume 153, Issue 9Page: 614-615KeywordsDecision makingHemorrhageInpatientsIntensive care unitsNursing homesPatientsResidencySleepSurgeryVancomycin ePublished: 2 November 2010 Issue Published: 2 November 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A CASE OF SUBACUTE BACTERIAL ENDOCARDITIS WITH APPARENT CURE
Authors: J. S. Druckman
Journal: JAMA (1941)

This case is reported to demonstrate the occasional value of sulfonamide derivatives in subacute bacterial endocarditis. Moreover, in this instance the superiority of the sulfonamide derivatives as compared to other agents in this disease is brought into relief by failure attending antecedent therapy. <h3>History.—</h3> Miss P. F. was first seen by me privately on Oct. 13, 1939. Her chief complaint was that of a swollen, tender area on the left foot of six days' duration. There was also a history of a rise in temperature to 102 F. in the afternoon, which had originated seven weeks previously in August 1939. Preceding this low grade temperature, gastrointestinal symptoms had developed in June 1939. These were dyspepsia, belching, constipation and anorexia. A loss of 17 pounds (7.7 Kg.) began at this time. The patient also mentioned recent anorexia and night sweats. Her past history was that of a chronic cardiac patient. She
Abstract 4895: Caveolin-1 modulates docetaxel activity by inducing p53 expression in breast cancer.
Authors: Joo Hee Park, Jin Ho Kang, Uk Hyun Jo, Eun Young Gil, Jong Kuk Park, Eun Sook Lee, Yeul Hong Kim, In Sun Kim, Kyong Hwa Park
Journal: Cancer Research (2012)

Abstract Caveolin-1 is reported to be down-regulated in breast cancers compared with normal mammary tissue. More recent data showed that high caveolin-1 expression is more associated with basaloid cancers than ER and/or PR or HER-2 expressing cancers. Investigatirs have reported that Caveolin-1 promoted resistance to chemotherapy-induced apoptosis in Ewing's sarcoma cells. However, the biologic relevance of caveolin-1 in breast cancer remains unclear. Thus, the aim of this study is to investigate its potential biologic relevance of Caveolin-1 to cell survival after docetaxel chemotherapy, one of the most important drug in breast cancer treatment. In this current study, we first showed that Caveolin-1 protein expression was suppressed in the ER(+) human breast cancer cell lines (MCF-7, T47D, and ZR75-1), but not in triple negative cancer cells (MDA-MB-231 and HS578T) and one of the HER-2 type cell (HCC1954) using Western blot analysis. Better cytotoxic effect of docetaxel was observed in the caveolin-1-expressing triple negative cells and HER-2 type cell than the other caveolin-1-deficient HER-2 type and luminal type of cancer cells. Next, caveolin-1 gene was reintroduced into caveolin-1 deficient luminal type breast cancer cells (MCF-7 and ZR75-1) to investigate its potential modulatory effect on docetaxel-induced cytotoxicity. The cell proliferation and MTT assay showed that the overexpressed caveolin-1 had further modulated docetaxel-induced anti-proliferative and cytotoxic effect in the luminal type cells. The anti-proliferative effect of docetaxel in the caveolin-1 gene over-expressed breast cancer cell lines was accompanied by decreasing cyclin D1 expression and inducing cyclin B1 accumulation, then resulting in cell cycle arrest at G2/M phase in the FACS analysis. In addition, re-introduction of caveolin-1 further increased docetaxel-induced cell death by synergistically inducing p53 expression and subsequent induction of p21, then finally apoptosis of breast cancer cells. These results were verified in the mouse model using SCID mice implated with either Caveolin-1-MCF-7 cells or control MCF-7 cells. When each group of tumor-bearing mice were treated by docetacel, mice with Caveolin-1-MCF-7 tumors showed a signiflcantly smaller tumors than those of control group. These results suggest that caveolin-1 may have a modulating factor for docetaxel activity by inducing p53 expression in breast cancer patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4895. doi:1538-7445.AM2012-4895
Dermatomal pruritus precipitated by drinking excessive quantities of black tea
Authors: L‐A. Murphy, C. Buckley
Journal: British Journal of Dermatology (2000)

Journal Article Dermatomal pruritus precipitated by drinking excessive quantities of black tea Get access L‐A. Murphy, L‐A. Murphy Department of Dermatology, Waterford Regional Hospital, Dunmore Road, Waterford, Ireland Search for other works by this author on: Oxford Academic Google Scholar C. Buckley C. Buckley Department of Dermatology, Waterford Regional Hospital, Dunmore Road, Waterford, Ireland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 6, 1 December 2000, Pages 1355–1356, https://doi.org/10.1046/j.1365-2133.2000.03939.x Published: 01 December 2000
Successful Unilateral Pulmonary Embolectomy without Cardiopulmonary Bypass
Authors: Merrill N. Bradley, Austen L. Bennett, Champ Lyons
Journal: New England Journal of Medicine (1964)

RECENT reports of successful pulmonary-artery embolectomy using cardiopulmonary bypass have renewed enthusiasm for the salvage of these patients by the direct surgical approach.1 , 2 The following case report illustrates an approach to pulmonary-artery embolectomy in which cardiopulmonary bypass was not necessary and also demonstrates the contribution of venous angiography to the diagnosis and subsequent treatment of pulmonary embolism.Case ReportW.C. (V.A.H. 03336), a 43-year-old colored diabetic man, was admitted to the hospital on January 20, 1964, because of a 3d-degree grease burn of the left foot. On February 14 split-thickness grafts from the right thigh were applied. On the 3d . . .
Systemic Anticoagulation And Intraocular Hemorrhage
Authors: Arthur C. Walsh
Journal: JAMA (1972)

<h3>To the Editor.—</h3> The article by Feman et al (220:1354, 1972) was valuable in drawing attention to the dangers of intraocular hemorrhage with anticoagulant therapy, but may give a somewhat distorted picture of the problem. The complication must be rather rare as I have seen very few reports and have had no such complications in treatment of more than a hundred patients in the last ten years. Besides, the prothrombin time in this patient was "over 100 seconds" which is above the usual therapeutic level of anticoagulation. The important point made by the authors could probably have been accomplished with less criticism. For one thing, pulmonary embolism is a serious condition and sometimes one has to choose between life and preservation of vision, and the physician's judgment at the time to use anticoagulant therapy may have, indeed, been the best choice. Besides, the patient was already losing some vision in
MicroRNAs control hepatocyte proliferation during liver regeneration
Authors: Guisheng Song, Amar Deep Sharma, Garrett R. Roll, Raymond Ng, Andrew Y. Lee, Robert H. Blelloch, Niels M. Frandsen, Holger Willenbring
Journal: Hepatology (2010)

MicroRNAs (miRNAs) constitute a new class of regulators of gene expression. Among other actions, miRNAs have been shown to control cell proliferation in development and cancer. However, whether miRNAs regulate hepatocyte proliferation during liver regeneration is unknown. We addressed this question by performing 2/3 partial hepatectomy (2/3 PH) on mice with hepatocyte-specific inactivation of DiGeorge syndrome critical region gene 8 (DGCR8), an essential component of the miRNA processing pathway. Hepatocytes of these mice were miRNA-deficient and exhibited a delay in cell cycle progression involving the G1 to S phase transition. Examination of livers of wildtype mice after 2/3 PH revealed differential expression of a subset of miRNAs, notably an induction of miR-21 and repression of miR-378. We further discovered that miR-21 directly inhibits Btg2 , a cell cycle inhibitor that prevents activation of forkhead box M1 (FoxM1), which is essential for DNA synthesis in hepatocytes after 2/3 PH. In addition, we found that miR-378 directly inhibits ornithine decarboxylase ( Odc1 ), which is known to promote DNA synthesis in hepatocytes after 2/3 PH. Conclusion : Our results show that miRNAs are critical regulators of hepatocyte proliferation during liver regeneration. Because these miRNAs and target gene interactions are conserved, our findings may also be relevant to human liver regeneration. (Hepatology 2010)
A Practical Approach to Angiography
Authors: David I. Abramson
Journal: JAMA (1979)

This handsomely presented volume on angiography consists of 22 chapters devoted initially to the presentation of fundamental information in the field, followed by a detailed discussion of specialized techniques requiring various degrees of expertise. The book is divided into five sections, consisting of descriptions of equipment and general methods, angiographic studies of body and organ systems, angiography of the heart and lungs, phlebography and lymphangiography, and techniques used for therapeutic purposes. The primary purpose of the monograph is to help lessen the dangers to patients associated with angiography, an invasive procedure with potential complications. Stress is placed on the fact that the method should not be undertaken unless noninvasive techniques have failed to provide information essential for the proper diagnosis and treatment of a patient with vascular difficulties. The practical approach to the technique of angiography is emphasized; at the same time, the text guides the inexperienced angiographer away from
The Pathogenesis of Podagra
Authors: PETER A. SIMKIN
Journal: Annals of Internal Medicine (1977)

Precipitation of crystals from solution is a relatively simple phenomenon that should be explained by changes in concentration, temperature, pH, or other local factors. Which of these factors determines the preferential precipitation of urate crystals at the base of the big toe? Podagra correlates with degenerative joint disease of the toe, often follows abuse of the feet, and classically occurs in the middle of the night. These characteristics suggest that crystals may form in resolving synovial effusions. The urate concentration must transiently rise in such an effusion because water will leave the joint space twice as fast as urate. If the local concentration surpasses the solubility of urate, crystals will form that may than induce acute podagra.
Chronic Vulvovaginal Candidiasis
Authors: David A. Eschenbach
Journal: New England Journal of Medicine (2004)

Vulvovaginal symptoms are common, and they represent one of the most frequent reasons for visits to physicians by women in all age groups. Vulvovaginitis is rarely life-threatening, and it is therefore vastly understudied and poorly understood. However, it is associated with substantial, albeit poorly quantified, cumulative morbidity. It causes genital discomfort, loss of productivity, reduced sexual pleasure, and psychological distress and necessitates medical expenditures.Noninfectious vulvovaginitis is caused by a wide variety of inflammatory, hypersensitivity, and collagen vascular conditions.1 The most common cause of infectious vulvovaginitis is candidiasis, which accounts for 40 to 50 percent of all cases. Vulvovaginitis primarily . . .
Oxygen free-radicals mediate an inhibition of proteoglycan synthesis in cultured articular cartilage.
Authors: E J Bates, D A Lowther, C J Handley
Journal: Annals of the Rheumatic Diseases (1984)

Superoxide radical, generated enzymatically by the action of xanthine oxidase on hypoxanthine, significantly inhibited proteoglycan synthesis by cultured bovine articular cartilage. This inhibition was not due to the generation of uric acid or to the generation of superoxide per se. It was immediate in onset and still evident after six days in culture. The inhibition was similar for both 35S-sulphate and 3H-acetate incorporation into glycosaminoglycans and could not be reversed by addition of beta-D-benzyl xyloside. Protein synthesis was also inhibited.
Efficacy of tyrosine kinase inhibitors (TKIs) as third-line therapy in patients with chronic myeloid leukemia in chronic phase who have failed 2 prior lines of TKI therapy
Authors: Amr R. Ibrahim, Christos Paliompeis, Marco Bua, Dragana Milojkovic, Richard Szydlo, Jamshid S. Khorashad, Letizia Foroni, Alistair Reid, Hugues de Lavallade, Katayoun Rezvani, Francesco Dazzi, Jane F. Apperley, John M. Goldman, David Marin
Journal: Blood (2010)
Ventricular Septal Defect
Authors: DONALD G. RITTER, ROBERT H. FELDT, WILLIAM H. WEIDMAN, JAMES W. DUSHANE
Journal: Circulation (1965)

Records of 273 cases of ventricular septal defect from five participating institutions were studied. Insignificant hemodynamic disturbance (Roger's) was found in 11 per cent, moderate to large left-to-right shunts in 55 per cent, and severe pulmonary vascular disease ("Eisenmenger's") in 8 per cent. Because of insufficient data, 26 per cent of the cases were not classified hemodynamically. Thus, a spectrum of severity ranging from mild to severe was noted. There was evidence of congestive heart failure in infancy in 78 cases and a significant mortality occurred in this group, whether treatment was medical (mortality, 27 per cent) or surgical (mortality, 46 per cent). Six patients had hemodynamic evidence of severe progressive pulmonary vascular disease, three when they were less than 8 years old. Correlations of hemodynamic severity with clinical symptoms, roentgenographic findings, and electrocardiographic changes were reasonably good at the extreme ends of the severity spectrum but only fair in the middle range. Over-all mortality was high (28 per cent) for the 163 patients treated surgically, but mortality was also high (18 per cent) for the 110 patients treated medically. Ten of the 20 deaths in the medical group occurred in patients who had had congestive heart failure in infancy. Further study of the natural history of ventricular septal defect is clearly indicated for establishment of improved criteria for selection of cases for operation.
Politics and Public Health
Authors: John K. Iglehart
Journal: New England Journal of Medicine (1996)

The rush to shrink the federal government and reduce its costs, propelled by the Republican-controlled Congress with the reluctant acquiescence of the Clinton administration, has begun to change the Public Health Service and other federal health agencies in important ways. The Republicans have begun to dismantle the offices of the assistant secretary for health and the surgeon general, as well as the Office of Technology Assessment (OTA); reduce funding for substance-abuse treatment, mental health services, and health services research; and consolidate many other public health programs. However, the House of Representatives has voted to continue Congress's long-standing commitment to the . . .