Central Nervous System Involvement in Ewing's Sarcoma
Authors: Merrill S. Kies, Peter S. Kennedy
Journal: Annals of Internal Medicine (1978)

Brief Reports1 August 1978Central Nervous System Involvement in Ewing's SarcomaMERRILL S. KIES, M.D., PETER S. KENNEDY, M.D.MERRILL S. KIES, M.D.Search for more papers by this author, PETER S. KENNEDY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-2-226 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEwing's sarcoma is an uncommon, highly malignant bone tumor requiring multimodal therapy for optimal treatment results. The use of adjuvant chemotherapy after primary surgery or radiotherapy, or both, has improved survival statistics for patients presenting with localized disease (1-3). Recent reports have emphasized the occurrence of central nervous system (CNS) metastases in long-term survivors treated with (1) or without (4) adjuvant chemotherapy and have recommended CNS prophylaxis to prevent such recurrences. We undertook the present investigation to better define the prevalence of CNS relapse in patients achieving remission of their primary tumor.The clinical and autopsy records of patients with...References1. POMEROY T and JOHNSON R: Combined modality therapy of Ewing's sarcoma. Cancer 35:36-47, 1975 CrossrefMedlineGoogle Scholar2. JAFFE N, TRAGGIS D, SALIAN S, and CASSADY J: Improved outlook for Ewing's sarcoma with combination chemotherapy (vincristine, actinomycin D, and cyclophosphamide) and radiation therapy. Cancer 38:1925-1930, 1976 CrossrefMedlineGoogle Scholar3. ROSEN G, WOLLNER N, TAN C, WU S, HAJDU S, CHAM W, D'ANGIO G, and MURPHY M: Disease-free survival in children with Ewing's sarcoma treated with radiation therapy and adjuvant four-drug sequential chemotherapy. Cancer 33:384-393, 1974 CrossrefMedlineGoogle Scholar4. MEHTA Y and HENDRICKSON F: CNS involvement in Ewing's sarcoma. Cancer 33:859-862, 1974 CrossrefMedlineGoogle Scholar5. MARSA G and JOHNSON R: Altered pattern of metastasis following treatment of Ewing's sarcoma with radiotherapy and adjuvant chemotherapy. Cancer 27:1051-1054, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MERRILL S. KIES, M.D.; PETER S. KENNEDY, M.D.Affiliations: Brooke Army Medical Center Fort Sam Houston, Texas PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAdjuvant hypofractionated partial-brain radiation therapy for pediatric Ewing sarcoma brain metastases: case reportBrain Metastasis in Bone and Soft Tissue Cancers: A Review of Incidence, Interventions, and OutcomesBrain Metastases from Ewing's SarcomaSarcoma Metastatic to the Brain: A Series of 15 CasesCerebral metastases in childhood malignanciesResection of brain metastases from sarcomaSarcoma Metastatic to the BrainSarcoma Metastatic to the BrainSolitary cerebellar metastasis from Ewing's sarcoma: case report and review of the literatureIntracranial metastasis in Ewing's sarcomaSolitary, isolated metastasis from Ewing's sarcoma to the brain: Case reportIsolated CNS involvement in Ewing's sarcomaMetastatic ewing's sarcoma to the brain: case report and review of treatmentEwing's sarcoma with intracranial metastasis presenting depressed cerebral blood flow and metabolism in the contralateral gray matterMetastatic Ewing's sarcoma to the skull: CNS involvement excluded by MRIActuarial risk of isolated cns involvement in Ewing's sarcoma following prophylactic cranial irradiation and intrathecal methotrexateSarcoma metastatic to the central nervous system parenchyma: A review of the literatureEwings’ SarcomaThe frequency of isolated CNS involvement in Ewing's SarcomaEwing's sarcoma: Ten-year experience with adjuvant chemotherapy 1 August 1978Volume 89, Issue 2Page: 226-227KeywordsAdjuvant chemotherapyAutopsyBoneCentral nervous systemProphylaxisSarcomaSurgery ePublished: 1 December 2008 Issue Published: 1 August 1978 PDF downloadLoading ...