tbuckley/cabot-search huggingface dataset:
Genetic Variations in Nitric Oxide Synthase 1 Adaptor Protein Are Associated With Sudden Cardiac Death in US White Community-Based Populations
Authors: W.H. Linda Kao, Dan E. Arking, Wendy Post, Thomas D. Rea, Nona Sotoodehnia, Ronald J. Prineas, Bryan Bishe, Betty Q. Doan, Eric Boerwinkle, Bruce M. Psaty, Gordon F. Tomaselli, Josef Coresh, David S. Siscovick, Eduardo Marbán, Peter M. Spooner, Gregory L. Burke, Aravinda Chakravarti
Journal: Circulation (2009)

Background— The ECG QT interval is associated with risk of sudden cardiac death (SCD). A previous genome-wide association study demonstrated that allelic variants (rs10494366 and rs4657139) in the nitric oxide synthase 1 adaptor protein ( NOS1AP ), which encodes a carboxy-terminal PDZ ligand of neuronal nitric oxide synthase, are associated with the QT interval in white adults. The present analysis was conducted to validate the association between NOS1AP variants and the QT interval and to examine the association with SCD in a combined population of 19 295 black and white adults from the Atherosclerosis Risk In Communities Study and the Cardiovascular Health Study. Methods and Results— We examined 19 tagging single-nucleotide polymorphisms in the genomic blocks containing rs10494366 and rs4657139 in NOS1AP . SCD was defined as a sudden pulseless condition of cardiac origin in a previously stable individual. General linear models and Cox proportional hazards regression models were used. Multiple single-nucleotide polymorphisms in NOS1AP , including rs10494366, rs4657139, and rs16847548, were significantly associated with adjusted QT interval in whites ( P &lt;0.0001). In whites, after adjustment for age, sex, and study, the relative hazard of SCD associated with each C allele at rs16847548 was 1.31 (95% confidence interval 1.10 to 1.56, P =0.002), assuming an additive model. In addition, a downstream neighboring single-nucleotide polymorphism, rs12567209, which was not correlated with rs16847548 or QT interval, was also independently associated with SCD in whites (relative hazard 0.57, 95% confidence interval 0.39 to 0.83, P =0.003). Adjustment for QT interval and coronary heart disease risk factors attenuated but did not eliminate the association between rs16847548 and SCD, and such adjustment had no effect on the association between rs12567209 and SCD. No significant associations between tagging single-nucleotide polymorphisms in NOS1AP and either QT interval or SCD were observed in blacks. Conclusions— In a combined analysis of 2 population-based prospective cohort studies, sequence variations in NOS1AP were associated with baseline QT interval and the risk of SCD in white US adults.
MPs call for review into government's treatment of scientific advisers
Authors: C. Dyer
Journal: BMJ (2009)

Protecting the independence of scientists who give expert advice to government must become “part of the culture” for UK government ministers and civil servants, an influential committee of MPs has said.

The House of Commons Science and Technology Committee is calling on the government to appoint a panel to carry out a review of the treatment of scientific advice across government, after the sacking of David Nutt as head of the Advisory Council on the Misuse of Drugs ( BMJ …
Iron excess treatable by copper supplementation in acquired aceruloplasminemia: a new form of secondary human iron overload?
Authors: Dorothée Videt-Gibou, Serge Belliard, Edouard Bardou-Jacquet, Marie-Bérengère Troadec, Caroline Le Lan, Anne-Marie Jouanolle, Olivier Loréal, Joseph Rivalan, Pierre Brissot
Journal: Blood (2009)
RENAL FLOW RESERVE AND RENAL RESISTANCE INDEX AFTER PERCUTANEOUS RENAL ANGIOPLASTY PREDICT RENAL FUNCTION LATE (12 MONTHS) AFTER PTRA
Authors: Yoji Neishi, Hiroyuki Okura, Shintaro Nezuo, Tetsuo Tsuchiya, Yoshinori Miyamoto, Ryotaro Yamada, Akihiro Hayashida, Takahiro Kawamoto, Kiyoshi Yoshida
Journal: Journal of the American College of Cardiology (2011)
913-118 Repeatability of Treadmill Exercise Ejection Fraction and Wall Motion Using Tc-99m Sestamibi First Pass Radionuclide Ventriculography
Authors: Boaz Benari, Hosen Kiat, Jacob Erel, Mark Hyun, Fan Ping Wang, Cyndi Williams, Guido Germano, Kenneth Van Train, John D. Friedman, Daniel S. Berman
Journal: Journal of the American College of Cardiology (1995)
On Medicine Rounds
Authors: GREG SIMON
Journal: Annals of Internal Medicine (1982)

Ad Libitum1 May 1982On Medicine RoundsGREG SIMONGREG SIMONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-5-686 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMr. Blount's tattoos speak of finer days; a battleship long rusted, a wife now dead.Mr. Blount doesn't speak at all, but if I ask him he will squeeze my hand—the silent language shared by lovers and the dying.I pat his shoulder with a deceptively firm hand, telling him everything will be all right.He must wonder how many other times I was wrong.I always yell at Mr. Hatch, as if more volume could pierce that fog behind his eyes.It never does.Today I make the ritual requests: Nod your head, tell me your name, look at... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Steuern in den inexakten preispolitischen HilfsverfahrenOrganic electrosyntheses in industry 1 May 1982Volume 96, Issue 5Page: 686-686KeywordsShoulders ePublished: 1 December 2008 Issue Published: 1 May 1982 PDF downloadLoading ...
Cell assemblies as building blocks of larger cognitive structures
Authors: J. Eric Ivancich, Christian R. Huyck, Stephen Kaplan
Journal: Behavioral and Brain Sciences (1999)

Pulverm&amp;uuml;ller's work in extending Hebb's theory into the realm of language is exciting. However, we feel that what he characterizes as a single cell assembly is actually a set of cooperating cell assemblies that form parts of larger cognitive structures. These larger structures account more easily for a variety of phenomena, including the psycholinguistic.
TREATMENT OF LIME BURN OF THE EYE
Authors: OTTO BARKAN
Journal: JAMA (1924)

Of all the injuries to the eye, among the most disastrous in its result is a burn, especially one due to the action of a chemical irritant, such as quicklime. It may result in adhesions of the conjunctiva, in opacification of the cornea with marked reduction of vision, and even in loss of the eyeball.  The treatment that we here suggest has, as its main effect, the restoration of vision through clearing of the corneal opacity. Its further beneficial effects are marked alleviation of acute symptoms and shortening of the inflammatory period. In view of its principal action, the clearing of the corneal opacity, this discussion will be limited in the main to lime burns of the cornea.  Ramsay thus describes the process of lime burn:  In the case of quicklime, the severity of the burn is due to the fact that the lime usually remains for a considerable period
Evidence for a hypothalamic disturbance in cyclical oedema.
Authors: J B Young, A M Brownjohn, C Chapman, M R Lee
Journal: BMJ (1983)

Fourteen women with cyclical oedema and six healthy female controls were investigated by use of a test in which thyrotrophin releasing hormone and luteinising hormone releasing hormone were given. Significant differences in the responses of prolactin, luteinising hormone, and follicle stimulating hormone were observed in the patients. These findings suggest that there may be a hitherto unrecognised hypothalamic defect in cyclical oedema that may account for some of the previously unexplained clinical features and lead to a more rational therapeutic approach in the management of the disorder.
Tumor-Associated (CEA-Reacting) Antigen in Patients with Inflammatory Bowel Disease
Authors: Allyn H. Rule, Eugene Straus, Jacques Vandevoorde, Henry D. Janowitz
Journal: New England Journal of Medicine (1972)

RECENT actuarial analyses of children with ulcerative colitis have clearly defined their increased mortality rates and incidence of cancer after 10 years of disease.1 Similarly, in an adult populat...
ULTRA-VIOLET LIGHT IN THE TREATMENT OF THE DULL AND BACKWARD CHILD
Authors: F. Sugden
Journal: BMJ (1930)

<h3>Abstract</h3> The newly identified Omicron (B.1.1.529) variant of Severe Acute Respiratory Syndrome Voronavirus 2 (SARS-CoV-2) has steered concerns across the world due to the possession of large number of mutations leading to high infectivity and vaccine escape potential. The Omicron variant houses 32 mutations in S protein alone. The viral infectivity is determined mainly by the ability of spike (S) protein receptor binding domain (RBD) to bind to the human Angiotensin I Converting Enzyme 2 (hACE2) receptor. In this paper, the interaction of the RBDs of SARS-CoV-2 variants with hACE2 was analyzed by using protein-protein docking and compared with the novel Omicron variant. Our findings reveal that the Omicron RBD interacts strongly with hACE2 receptor via unique amino acid residues as compared to the Wuhan and many other variants. However, the interacting residues of RBD are found to be the same in Lamda (C.37) variant. These unique binding of Omicron RBD with hACE2 suggests an increased potential of infectivity and vaccine evasion potential of the new variant. The evolutionary drive of the SARS-CoV-2 may not be exclusively driven by RBD variants but surely provides for the platform for emergence of new variants.
Treatment of Basal Cell Carcinoma
Authors: Michael M. Schreiber
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Dr. Gilbert Eade (229:23, 1974) is correct in not subjecting everyone he sees with a basal cell carcinoma to the skills and expertise of a board-certified plastic surgeon like himself. Nevertheless, I believe he is incorrect in his assumption that if the lesion is slow-growing, it is not a great concern, and that the problems that can arise with these lesions are rarely important. It is true that basal cell carcinomas rarely metastasize, but they do. What is even more important is that basal cell carcinomas notoriously can invade deeply in and around blood vessels and nerves, and even invade bone—producing no clinically significant problem until it does become necessary to call a plastic surgeon. When these lesions are found early, a 95% cure rate can be achieved quite easily by almost any dermatologist using the simple modality of curettage and desiccation. This procedure does not require hospitalization,
S94 A Prospective Study Investigating Oral Corticosteroid (ocs) Use And Quality Of Life In Omalizumab Treated Severe Allergic Asthma Patients - Results From An Interim Analysis Of The Apex Ii Study
Authors: R. Chaudhuri, A. Menzies-Gow, H. Khachi, S. Hand, R. Gore, R. Niven
Journal: Thorax (2014)

<h3>Background</h3> A previous retrospective study of UK clinical practice demonstrated that omalizumab reduced OCS burden. <h3>Aim</h3> This multi-centre observational study was conducted to confirm the observed retrospective findings prospectively. <h3>Methods</h3> Retrospective data were collected in the 12 months prior to omalizumab, while prospective data were collected at 16 weeks, 8 and 12 months following initiation. The primary endpoint was the change in mean daily OCS dose in the 12 months pre and post omalizumab initiation. Secondary endpoints included changes in ACT and AQLQ scores in the 12 months pre and post omalizumab initiation. <h3>Results</h3> 235 patients were enrolled by the end December 2013 in 22 UK centres. Data for interim analysis were examined from patients who had 12 months assessment at database lock (n = 85, 54% females, mean (±SD) age 44 yr (±13.2), mean (±SD) duration of asthma 26 yr (±14.0)). At the 16 weeks assessment 74/85 (87%) patients were classified as responders to omalizumab treatment. At 12 months, mean daily OCS dose decreased by 25% (n = 85, p &lt; 0.001) from 10.77 mg/day (±7.87) to 8.08 mg/day (±8.39) and 55% (n = 46/84) of patients stopped OCS. 71% (n = 60/85) of patients stopped or reduced OCS by ≥20%. Comparing the 12 months periods prior to and following initiation of omalizumab, the mean ACT score improved from 9.8 (±4.8) to 14.2 (±5.2) (n = 75, p &lt; 0.001) and the mean AQLQ score improved from 3.1 (±1.3) to 4.3 (1.46) (n = 60, p &lt; 0.001) [Graph 1]. <h3>Conclusions</h3> The data prospectively confirms that omalizumab is associated with statistically and clinically significant reduction in OCS and statistically and clinically significant improvement in asthma symptom control and quality of life.
Color Doppler evaluation of valvular regurgitation in normal subjects.
Authors: K Yoshida, J Yoshikawa, M Shakudo, T Akasaka, Y Jyo, S Takao, K Shiratori, K Koizumi, F Okumachi, H Kato
Journal: Circulation (1988)

To determine prospectively the prevalence of mitral, aortic, tricuspid, and pulmonary regurgitation in normal persons, 211 consecutive, apparently healthy volunteers were examined with a color Doppler flow imaging system. The subjects were divided into five age groups (group 1, 6-9 years old; group 2, 10-19 years old, group 3, 20-29 years old, group 4, 30-39 years old, and group 5, 40-49 years old). The prevalence rate of mitral regurgitation in the normal subjects was 38-45% in each group. The mitral regurgitant jets came from the posteromedial commissure in all but two subjects. No aortic regurgitant flow signals were detected in the normal subjects. Tricuspid regurgitation was detected in 15-77% in each group, and pulmonary regurgitation was detected in 28-88%. Regarding the tricuspid and pulmonic valves, the prevalence rate of regurgitation is age dependent (p less than 0.01) and tends toward the lower rate in groups over the age of 30 years. The tricuspid and pulmonary regurgitant jets came from the center of the coaptation of each valve. The area of the regurgitant jet signals in normal persons was significantly smaller (p less than 0.001) than that obtained from patients with organic valve disease. Our study shows that in a large proportion of normal persons under the age of 50 years color Doppler echocardiography permits recording of regurgitant signals behind all valves except the aortic. In conclusion, one should be aware of the existence and characteristics of regurgitation in normal persons when evaluating valvular regurgitation by Doppler techniques.
Remarks on the Present Aspect of Medicine
Authors: W. Newnham
Journal: BMJ (1848)

We are not prepared to say that much of the practice in the present day is not mere guess-work, especiallv with those who see their patients perhaps but once, or at all events, at very distant intervals; who have no opportunity of watching the influence of theirmedicines, and modifying that influence according to the peculiar state of the constitution, and rectifying the mistakes or imperfect knowledge of to.day, by the enlarged kmowledge of to.morrow, and by the close observation of disease.We believe that a physician, in order to be a successful practitioner, and to carry out his plans, and to develope the agencies of medicine, should be a! close attendant upon his patient; and where he is not so, we are not surprised at his hesitating to employ active measures, and at his trusting more to the do-nothiny system of regimen (because it will do no harm,) rather than to the do-something system of medi.cine,over the influence of which he bears no regulating control; but this again is an error of the system of admtziatration, and detracts not from the power of ihedicine.Now, as to the influence of "Young Physic" in correcting these errors, and in working out the projected reformation,we have no means of judging of his powers.Shi far as parentage is concerned, since fortes creantur fortibus, we ought to expect much good from his futuro Herculean labours; but since we do find sometimes that;children differ essentially from the direct parent stock, and are influenced by some previous bend sinister in the family escutcheon, we cannot yet rely upon what may be hiE developed powers.We cannot but
Treatment of Primary Moderate Hypercholesterolemia With Lovastatin (Mevinolin) and Colestipol
Authors: Gloria Lena Vega
Journal: JAMA (1987)

The introduction of inhibitors of cholesterol biosynthesis offers a new approach to treatment of hypercholesterolemia. One such agent, lovastatin (formerly, mevinolin), causes significant reductions in plasma cholesterol levels. This action can be enhanced by bile acid sequestrants. In this study, lovastatin and colestipol hydrochloride together were administered to ten patients with primary moderate hypercholesterolemia. Compared with a control period, the combined-drug therapy caused a 36% reduction in plasma total cholesterol level, a 48% decrease in low-density lipoprotein (LDL) cholesterol level, and a 17% increase in high-density lipoprotein cholesterol level. The reduction in LDL cholesterol level was due to three factors: (1) a 27% decrease in the production rate of LDL, (2) a 20% increase in fractional catabolic rate of LDL, and (3) a 15% depletion of cholesterol in LDL particles. This major reduction in LDL cholesterol level produced by combined-drug therapy may be valuable for prevention of coronary heart disease in high-risk patients with primary moderate hypercholesterolemia. (<i>JAMA</i>1987;257:33-38)
A Critical Role of Perinuclear Filamentous Actin in Spatial Repositioning and Mutually Exclusive Expression of Virulence Genes in Malaria Parasites
Authors: Qingfeng Zhang, Yufu Huang, Yilong Zhang, Xiaonan Fang, Aurelie Claes, Magalie Duchateau, Abdelkader Namane, Jose-Juan Lopez-Rubio, Weiqing Pan, Artur Scherf
Journal: Cell Host & Microbe (2011)
The legal position
Authors: A. Burrows
Journal: BMJ (1997)

From a legal perspective there are two main questions. Is a doctor in breach of the duty of confidence owed to a patient by disclosing information about the patient to a third party, such as the Driver and Vehicle Licensing Agency or the patient's employer? May a doctor be liable in negligence, to a person injured by a patient, for not having disclosed information about the patient to, for example, the licensing agency or the patient's employer?

As regards the first question, doctors have a legal duty to …
Natural History of CNS Relapse in Aggressive Non-Hodgkin's Lymphoma: What Have We Learned?
Authors: Marc C. Chamberlain
Journal: Journal of Clinical Oncology (2009)

Bernstein et al 1 are to be congratulated for their recently reported phase III trial (four-arm randomization) in newly diagnosed patients with aggressive non-Hodgkin's lymphoma (NHL) and assessment of CNS relapse.I would like to make several comments regarding the report and the need for risk stratification regarding CNS-directed therapy in newly diagnosed patients with aggressive NHL.Five key issues appear relevant with respect to CNS prophylaxis in aggressive NHL.First, is there a consensus that CNS disease (mostly lymphomatous meningitis) is clinically relevant?2][3][4][5][6] Among patients with CNS relapse, half have poorly responding or refractory systemic disease.Therefore, the number of patients with NHL-isolated CNS is comparatively small.Second, is there a consensus regarding identification of high-risk (for CNS relapse/disease) patients with aggressive NHL?2][3][4][5][6] Notwithstanding this recognition of high-risk features, no study of newly diagnosed aggressive NHL has attempted to stratify patients with respect to CNS risk and CNSdirected therapy.Third, and as mentioned by Bernstein et al, 1 high-risk patients are often found at diagnosis (approximately 25%), if evaluated by CSF flow cytometry, to have contamination of the CSF by lymphoma. 7his suggests that a subset of patients with aggressive NHL and without neurological symptoms has occult lymphomatous meningitis at diagnosis.Importantly, CSF flow cytometry appears superior to CSF cytology with appropriate caveats regarding laboratory methodology for demonstrating lymphomatous involvement of the CSF.Notwithstanding this subset of patients with occult lymphomatous meningitis, the majority of patients with CNS relapse have negative CSF evaluation at diagnosis.Nevertheless, the study by Hegde et al 7 is compelling for mandatory CSF evaluation in patients defined as at high risk for CNS relapse at time of up-front therapy.Fourth, is there evidence that CNS prophylaxis is of benefit?This query is problematic as for the majority of patients (Ͼ 75%), risk of CNS disease is sufficiently low (Ͻ 2%) that most randomized trials
HEART TRANSPLANTATIONS IN THE NORDIC ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY REGISTRY
Authors: Pyotr G. Platonov, Thomas Gilljam, Anders G. Holst, Kristina H. Haugaa, Thor Edvardsen, Rasmus Borgquist, Ole Eschen, Jim Hansen, Henning Bundgaard, Jesper H. Svendsen
Journal: Journal of the American College of Cardiology (2013)
Liver disease and the e antigen in HBsAg carriers with chronic renal failure.
Authors: G P Coughlin, A G Van Deth, A P Disney, J Hay, A G Wangel
Journal: Gut (1980)

This study was undertaken to assess the frequency of development and the stages of evolution of chronic liver disease in patients with renal failure who are chronic carriers of hepatitis B surface antigen. Cirrhosis or chronic active hepatitis developed in five of 21 patients and could not be predicted by the initial histological appearance or by HLA-A and B typing but was associated with the e antigen in four of the five patients. However, the antigen was not a consistent indicator of a poor prognosis, as the four other e antigen positive patients did not develop chronic liver disease during the period of the study. Transmission of hepatitis B to spouses occurred in four cases, was fatal in one instance, and was associated with e antigen in three of the four. Determination of e antigen status in renal unit patients who are carriers of hepatitis B surface antigen may be of value to the patient and his home environment.
Analysis of Flow-Directed Pulmonary Artery Catheterization
Authors: David H. Spodick
Journal: JAMA (1989)

NOT ALL the maneuvers directed toward benefiting patients necessarily result in<i>net</i>benefit—a situation we readily accept in conscientiously attempting to avoid the toxic effects, complications, and side effects of medical and surgical treatments. Yet, like treatments, invasive diagnostic procedures present complications and side effects that may be less comprehensively appreciated. In this issue ofThe Journal, Carlson and colleagues<sup>1</sup>report pulmonary artery hemorrhage, a rare complication of flow-directed pulmonary artery catheterization, in three patients, one of whom was adroitly treated with therapeutic embolism. While the authors list risk factors for this complication (to which could be added recent cardiopulmonary bypass), their report should be considered in a broader context—that of indications for catheterization and the panoply of recognized complications, summarized in the Table, as well as the poorly understood physiological burden imposed by the presence of intravascular instrumentation itself.<sup>2</sup> <h3>Recognized Complications</h3> The precise incidence of recognizable complications