tbuckley/cabot-search huggingface dataset:
Evolution: The First Four Billion Years
Authors: Robert Root-Bernstein
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Altered Expression and Localization of Creatine Kinase B, Heterogeneous Nuclear Ribonucleoprotein F, and High Mobility Group Box 1 Protein in the Nuclear Matrix Associated with Colon Cancer
Authors: Manimalha Balasubramani, Billy W. Day, Robert E. Schoen, Robert H. Getzenberg
Journal: Cancer Research (2006)

Abstract Identification of biomarkers could lead to the development of effective screening tests for colorectal cancer. A previous study from our laboratory showed specific alterations of nuclear structure in colon cancer. In an effort to characterize these biomarkers, protein spots were selected from separations made by two-dimensional gel electrophoresis, which were analyzed by mass spectrometry. The sequences obtained from the isolated spots revealed that they have close similarity to creatine kinase B (CKB) isoforms, heterogeneous nuclear ribonucleoprotein F (hnRNP F) and high mobility group box 1 protein (HMGB1) isoforms. To determine the expression of these proteins in colon cancer, expression was studied in 9 tumor and matched adjacent normal pairs, 5 donor colons, 16 polyps, 4 metastatic liver lesions and matched adjacent normal pairs, and 3 liver donors. CKB and hnRNP F were expressed in 78% and 89% of colon tumors, respectively. hnRNP F had a higher frequency of expression than CKB in premalignant polyps. With the establishment of differential expression of the proteins in colon cancer, their subcellular localization was analyzed. The subcellular fractions studied both showed high protein levels of hnRNP F in colon tumors compared with normal colon tissues. Surprisingly, subcellular levels of CKB were decreased in colon tumors, suggesting that the observed high CKB levels in nuclear matrix extracts are caused by the enhanced localization of CKB to the nuclear matrix during colon tumorigenesis. These results suggest an involvement of hnRNP F and CKB in colorectal cancer. Additionally, they suggest that hnRNP F is a potential marker for colorectal cancer progression. (Cancer Res 2006; 66(2): 763-9)
Neuroendocrine breast cancer: retrospective analysis of 96 patients and review of literature
Authors: Francesca Rovera, Matteo Lavazza, Stefano La Rosa, Anna Fachinetti, Corrado Chiappa, Marina Marelli, Fausto Sessa, Giovanni Giardina, Rossana Gueli, Gianlorenzo Dionigi, Stefano Rausei, Luigi Boni, Renzo Dionigi
Journal: International Journal of Surgery (2013)
Remarks on Onychia Maligna
Authors: W. Maccormac
Journal: BMJ (1873)

A FEW years ago, I had many opportunities of observing cases onychia maligna.The name, by no means an inappropriate was given to the disease by Wardrop, and I do not think any since been invented.I was impressed by the inveterate nature of the malady, intolerable pain usually experienced by the sufferers, frequently them of natural rest, and the precise similarity, amongst coming under my observation, of one case to another.Local tions, or the evulsion of the nail, for the most part, produced but tem- porary good effects.The diseased condition would reappear patient resumed work, or the nail became reproduced.ment which proved effectual in my hands, whilst it restored soonest to work, was the complete excision of the secreting at the root of the nail.This is a severe operation.One cut widely and pretty deeply, especially at the base and angles, the matrix, and a large wound is the result.Anoesthesia, local or general, is required; and one of the earliest deaths from chloroform was caused in this way, whilst at least two others one them in St. Thomas's Hospital, many years ago.If, however, the operation be thoroughly performed, can-
IMMUNOFLUORESCENT EXAMINATION OF THE HUMAN CHORIONIC VILLUS FOR BLOOD GROUP A AND B SUBSTANCE
Authors: H. A. Thiede, J. W. Choate, H. H. Gardner, H. Santay
Journal: The Journal of Experimental Medicine (1965)

The chorionic villi of term placentas were examined for A and B blood group substance using the IF technique with heterologous and homologous antisera. No specific fluorescence was found in either the villous trophoblast or vessels of the chorionic villi. The implications of these findings in relation to the question of trophoblastic antigenicity are discussed.
Barcoded Medication Administration
Authors: David W. Cescon, Edward Etchells
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Drug Treatment of Convulsive Disorders
Authors: J. Gordon Millichap
Journal: New England Journal of Medicine (1972)

THE choice of drugs in the treatment of convulsive disorders is dependent on the clinical pattern of the seizure and the electroencephalographic abnormality. A description of seizures1 and electroencephalographic correlates2 is an important preliminary to the discussion of therapy.3 The clinical manifestations of seizures are diverse, but the majority can be classified in four groups as follows: major, minor, psychomotor and focal.Seizure PatternsMajor Seizure Patterns Grand mal. Grand-mal seizures are generalized convulsions characterized by an aura, sudden loss of consciousness, tonic or clonic spasms (or both) of the musculature and postictal sleep. Status epilepticus. Status epilepticus . . .
Pulmonary Sarcoidosis: A Prospective Evaluation of Glucocorticoid Therapy
Authors: ROBERT L. YOUNG
Journal: Annals of Internal Medicine (1970)

Glucocorticoid therapy has long been advocated for treatment of pulmonary dysfunction in sarcoidosis. No controlled prospective study in current medical literature establishes the efficacy of such therapy. Four years ago a prospective study using alternate-case treatment with prednisone was initiated in patients with pulmonary function abnormalities due to sarcoidosis. The two groups were similar in sex, age, race, degree of pulmonary dysfunction, and duration of disease. Patients were evaluated with complete spirometric studies, single-breath carbon monoxide diffusing capacity, and arterial blood gases. Serial studies of 1 to 2 years in duration were available for each patient and showed no difference between the treated and untreated groups. Improvement or deterioration in pulmonary function of individual patients in the treated group was matched by similar changes in the controls. Data from this study failed to prove that glucocorticoid therapy produced any beneficial change in pulmonary function.
Mayo prognostic model for WHO-defined chronic myelomonocytic leukemia: ASXL1 and spliceosome component mutations and outcomes
Authors: M M Patnaik, E Padron, R R LaBorde, T L Lasho, C M Finke, C A Hanson, J M Hodnefield, R A Knudson, R P Ketterling, A Al-kali, A Pardanani, N A Ali, R S Komroji, A Tefferi
Journal: Leukemia (2013)
Insulin-like Growth Factors
Authors: T J Merimee, J Zapf, E R Froesch
Journal: New England Journal of Medicine (1983)

To determine whether two insulin-like growth factors (IGF I and IGF II) influence the course of diabetic retinopathy, we measured the concentrations of these factors in 80 adult patients with diabetes and in 62 control subjects. In seven patients with Type I diabetes and rapidly deteriorating vision as a result of proliferative and exudative retinopathy, the serum concentration of IGF I was 722 +/- 41 ng per milliliter (mean +/- S.E.M.), as compared with 381 +/- 48 ng per milliliter in 26 patients who had Type I diabetes without retinopathy or with less severe forms of it, and 302 +/- 15 ng per milliliter in the controls (P less than 0.001 for both comparisons). Serum concentrations of IGF II were normal in subjects with Type I diabetes but were somewhat depressed in those with Type II disease. Whether elevated serum concentrations of IGF I cause the accelerated development of retinopathy in some patients remains to be determined. Such levels do appear to identify patients at high risk for rapid deterioration of vision, and hence may be useful in selecting patients for more intensive or alternative forms of therapy.
Mutations in genes encoding subunits of RNA polymerases I and III cause Treacher Collins syndrome
Authors: Johannes G Dauwerse, Jill Dixon, Saskia Seland, Claudia A L Ruivenkamp, Arie van Haeringen, Lies H Hoefsloot, Dorien J M Peters, Agnes Clement-de Boers, Cornelia Daumer-Haas, Robert Maiwald, Christiane Zweier, Bronwyn Kerr, Ana M Cobo, Joaquín F Toral, A Jeannette M Hoogeboom, Dietmar R Lohmann, Ute Hehr, Michael J Dixon, Martijn H Breuning, Dagmar Wieczorek
Journal: Nature Genetics (2010)
Accidental infection of man with Mycoplasma caviae.
Authors: A Hill
Journal: BMJ (1971)

Demyelination caused by inflammation of the CNS has been considered to be a major hallmark of multiple sclerosis (MS). Using experimental autoimmune encephalomyelitis, a model of MS, we demonstrate that an immune-mediated attack of the optic nerve is accompanied by an early degeneration of retinal ganglion cells (RGCs). The decrease of neuronal cell density was correlated with functional disabilities as assessed by visual evoked cortical potentials and electroretinogram. Visual acuity was significantly reduced. DNA degradation and activation of caspase-3 in RGCs indicate that cell death of RGCs is apoptotic. These findings show for the first time that an inflammatory attack against myelin components can lead to acute neuronal cell loss by apoptosis.
TREATMENT OF TYPHOID CARRIERS WITH IODOPHTHALEIN
Authors: Walter H. Baer
Journal: JAMA (1942)

<h3>To the Editor:—</h3> There appeared in a recent issue ofThe Journal(April 25, p. 1447) an article by Drs. Windsor C. Cutting and G. Bernard Robson entitled "Treatment of Typhoid Carriers." According to this paper, treatment of 5 typhoid carriers with soluble iodophthalein failed to cure the carrier state. Although it is realized that the authors did not have knowledge of our recently published study (<i>ibid.</i>, March 21, p. 964), it appears that the reader ofThe Journalmay be wrongly impressed with the value of such treatment. It is for this reason that we desire to make the following statements: The iodophthalein treatment is not an all out cure of all typhoid carriers. Only a definite, well defined group of carriers will respond to treatment. These are carriers who present typhoid bacilli in their bile, as obtained by duodenal drainage, and a well functioning gallbladder, as determined
P1095 HBVRNA IN SERUM IS A PREDICTOR OF HBeAg SEROCONVERSION IN PATIENTS WITH CHRONIC HEPATITIS B RECEIVING TREATMENT WITH PEG-INTERFERON ALPHA-2a (40KD)
Authors: F. van Bömmel, A. van Bömmel, H. He, C. Wat, D. Deichsel, T. Berg, S. Böhm
Journal: Journal of Hepatology (2014)
PROGNOSIS IN "PROCESS" AND "NON-PROCESS" SCHIZOPHRENIA
Authors: JOSEPH H. STEPHENS, CHRISTIAN ASTRUP
Journal: American Journal of Psychiatry (1963)

The relative success in dividing a group of patients into subgroups with varying outcomes depends in part, of course, on the nature of the original group and the criteria by which the diagnosis of schizophrenia was first made. In the group we have studied it was found that the risk of deterioration was very light in the "non-process" patients whereas the prognosis was grave in the "process" group. Nevertheless, although about half of the "process" patients were badly deteriorated on follow-up, we were unable to predict which particular "process" patients would either improve or worsen after discharge. Thus fatalistic pessimism about a particular schizophrenic patient is unwarranted. We cannot say on the basis of our study whether we are dealing with discrete kinds of disease processes or different points on a continuum. However, our findings do support, for practical purposes, Bleuler's concept of "groups of schizophrenias" rather than an entity "schizophrenia"(7). Our findings are thus in agreement with those of Freyhan(18) who has urged that we re-examine Bleuler's concepts which are no less pertinent today than 40 years ago. The persisting notion of "schizophrenia" as an entity can only impede understanding and research. European phenomenological studies, unfortunately little known in this country, may provide some clarification in this confusing field.
TCT-403 Impact of Bifurcation Lesion Treatment with DES on Clinical Outcomes: Results from the Prospective, Multicenter ADAPT-DES Study
Authors: Bernhard Witzenbichler, Bruce R. Brodie, David Cox, Peter L. Duffy, Timothy D. Henry, Ajay J. Kirtane, Ernest L. Mazzaferri, Roxana Mehran, D. Christopher Metzger, Franz-Josef Neumann, Helen Parise, Gregg Stone, Thomas Stuckey, Giora Weisz, Ke Xu
Journal: Journal of the American College of Cardiology (2013)
A Trial of Imaging Selection and Endovascular Treatment for Ischemic Stroke
Authors: Chelsea S. Kidwell, Reza Jahan, Jeffrey Gornbein, Jeffry R. Alger, Val Nenov, Zahra Ajani, Lei Feng, Brett C. Meyer, Scott Olson, Lee H. Schwamm, Albert J. Yoo, Randolph S. Marshall, Philip M. Meyers, Dileep R. Yavagal, Max Wintermark, Judy Guzy, Sidney Starkman, Jeffrey L. Saver
Journal: New England Journal of Medicine (2013)

Whether brain imaging can identify patients who are most likely to benefit from therapies for acute ischemic stroke and whether endovascular thrombectomy improves clinical outcomes in such patients remains unclear.
On the role of antidiuretic hormone in the inhibition of acute water diuresis in adrenal insufficiency and the effects of gluco- and mineralocorticoids in reversing the inhibition
Authors: Howard H. Green, Avery R. Harrington, Heinz Valtin
Journal: Journal of Clinical Investigation (1970)

In order to determine whether or not antidiuretic hormone (ADH) is essential to the inhibition of an acute water diuresis in adrenal insufficiency, the response to oral water loads was tested in rats with hereditary hypothalamic diabetes insipidus (DI) which lack ADH. It was found that 60 min after water loads of 3 or 5% of body weight urine flow was significantly lower and urine osmolality significantly higher in adrenalectomized DI rats than in the same DI rats before removal of their adrenal glands.
The Sweat Gland and Systemic Disease.
Authors: Richard L. Dobson
Journal: Annals of Internal Medicine (1964)

s1 October 1964The Sweat Gland and Systemic Disease.Richard L. Dobson, M.D., F.A.C.P.Richard L. Dobson, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-814_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo evaluate the results of sweat electrolyte studies, particularly in adults, a thorough knowledge of normal eccrine sweat gland function is essential. Recent studies have provided enough data so that a reasonable model of normal function can be presented. The diminished sweat sodium concentrations in nephrosis, cirrhosis, and congestive heart failure can be explained on the basis of increased circulating aldosterone, which increases sodium reabsorption of the sweat duct. In cystic fibrosis of the pancreas (CFP) in children sweat electrolytes are almost always elevated. This is probably due to a failure of sodium reabsorption by the duct. In an attempt... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Richard L. Dobson, M.D., F.A.C.P.Affiliations: Portland, Ore. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1964Volume 61, Issue 4Page: 814-814KeywordsChildrenCirrhosisCystic fibrosisHeart failurePancreasSaltsSodiumSweatSweat glandsSystemic diseases ePublished: 1 December 2008 Issue Published: 1 October 1964 PDF downloadLoading ...
Depicting the role of TP53 in hepatocellular carcinoma progression
Authors: Augusto Villanueva, Yujin Hoshida
Journal: Journal of Hepatology (2011)

Mutations in TP53, a tumor suppressor gene, are associated with prognosis of many cancers. However, the prognostic values of TP53 mutation sites are not known for patients with hepatocellular carcinoma (HCC) because of heterogeneity in their geographic and etiologic backgrounds.TP53 mutations were investigated in a total of 409 HCC patients, including Chinese (n=336) and white (n=73) patients, using the direct sequencing method.A total of 125 TP53 mutations were found in Chinese patients with HCC (37.2%). HCC patients with TP53 mutations had a shorter overall survival time compared with patients with wild-type TP53 (hazard ratio [HR], 1.86; 95% confidence interval [CI]: 1.37-2.52; P<.001). The hot spot mutations R249S and V157F were significantly associated with worse prognosis in univariate (HR, 2.11; 95% CI: 1.51-2.94; P<.001) and multivariate analyses (HR, 1.79; 95% CI: 1.29-2.51; P<.001). Gene expression analysis revealed the existence of stem cell-like traits in tumors with TP53 mutations. These findings were validated in breast and lung tumor samples with TP53 mutations.TP53 mutations, particularly the hot spot mutations R249S and V157F, are associated with poor prognosis for patients with HCC. The acquisition of stem cell-like gene expression traits might contribute to the aggressive behavior of tumors with TP53 mutation.
The Differentiation of Bronchiogenic Carcinoma and Pulmonary Tuberculosis
Authors: Nahum R. Pillsbury, Joseph D. Wassersug
Journal: New England Journal of Medicine (1945)

BECAUSE of the many clinical and roentgenologic similarities of bronchiogenic carcinoma and pulmonary tuberculosis, their differentiation may present certain diagnostic difficulties. Among examination. An approximately equal number of cases were seen in the Diagnostic Clinic of the hospital, and the majority were referred for consultation with a thoracic surgeon. Since these patients Overholt's1 cases of primary cancer of the lung, there were 40 patients who were treated for pulmonary tuberculosis because of an originally erroneous diagnosis. Similarly, Moersch and Tinney2 reported that in their series of 448 patients with proved bronchiogenic carcinoma, 13 spent several months in tuberculosis sanatoriums before . . .
REMARKS ON THE TREATMENT OF PROLIFEROUS INFLAMMATION OF THE MIDDLE EAR.Read before the Northwestern Wisconsin Medical Society, at New London, July 8, 1890.
Authors: H. V. WÜRDEMANN
Journal: JAMA (1891)

Chronic non-suppurative inflammation of the middle ear has been well divided by one of our American writers into two great classes (St. John Roosa):— CATARRHAL AND PROLIFEROUS. Politzer and Gruber accept the same classification but under different names. Others subdivide these terms, giving each a local habitation according to its most conspicuous lesion. By proliferous disease is meant that form of chronic non-suppurative catarrh in which there are marked changes in increase or hypertrophy of tissue, attended by little or no fluid secretion,<i>i. e.</i>, a dry catarrh (Roosa.) This disease is characterized chiefly by its insiduous course, having little or no symptoms beyond gradually increasing deafness and tinnitus aurium. It eventuates in entire sclerosis (hence the name given to it, by some writers, of "sclerosis of the middle ear") and profound deafness. The tinnitus may indeed be the only symptom of which the patient may complain. He may indignantly
Most sweeping changes in civil law for a century
Authors: C. Dyer
Journal: BMJ (1988)

The Civil Justice Review, published last week, is the most sweeping agenda for change in the civil courts of England and Wales for over a century.If adopted it will mean a massive shift of business from the High Court to the county court, which will try most cases concerning £25 000 or less.With the aim of cutting the delays that plague the system new timetables will be set for the steps in litigation, with the court exercising much more control over the progress of cases.Charged by the Lord Chancellor with the task of finding ways to cut costs, delay, and complexity, the team of officials, lawyers, and