tbuckley/cabot-search huggingface dataset:
The Myocardium After Repeated Infarction
Authors: Zenonas Danilevicius
Journal: JAMA (1977)

Dash et al<sup>1,2</sup>have described a cardiomyopathic syndrome due to coronary artery disease as a separate disease entity. The description was published in two sequences, part al<sup>1,2</sup>describing the relation of the syndrome to the extent of angiographically proved coronary disease and to remote myocardial infarction, and part 2 presenting the increased prevalence of this syndrome in patients with diabetes mellitus. Dash et al indicate that cardiomyopathic syndrome is specifically related to the decreased blood flow in the proximal coronary artery segments and to previous multiple myocardial infarcts. They present several distinguishing characteristics that make this cardiomyopathic syndrome different from cardiomyopathy owing to several other causes of chronic heart failure. Naturally, coronary heart disease always leads to decreased myocardial perfusion in some areas of the heart muscle. Arteriosclerotic changes, plaques, and calcifications do make the lumen of the coronary arteries smaller, and less blood is supplied to certain areas
A Central Thermogenic-like Mechanism in Feeding Regulation: An Interplay between Arcuate Nucleus T3 and UCP2
Authors: Anna Coppola, Zhong-Wu Liu, Zane B. Andrews, Eric Paradis, Marie-Claude Roy, Jeffrey M. Friedman, Daniel Ricquier, Denis Richard, Tamas L. Horvath, Xiao-Bing Gao, Sabrina Diano
Journal: Cell Metabolism (2007)
The Reaction of Articular Cartilage to Injury and Osteoarthritis
Authors: Henry J. Mankin
Journal: New England Journal of Medicine (1974)

Alterations in Cartilage in OsteoarthritisThe morphologic changes in joints affected by osteoarthritis were identified in writings of the Hunter brothers over 200 years ago.88 Over the intervening years, alterations in gross morphology were correlated with histologic changes, and the pattern now thought to be pathognomonic for this disorder clearly identified. In 1942, Bennett, Waine and Bauer104 presented their classic monograph, which described the progression of changes seen in the development of osteoarthritis of the knee, and seven years later, Collins105 established a classification system for the joint changes on which much of the current work is based.Before the . . .
119 NEGATIVE COSTIMULATORY MOLECULE PD1 UP-REGULATION ON CD8+ CELLS DURING PERSISTENT HCV INFECTION
Authors: S. Benito, J.R. Larrubia, E. Sanz-de-Villalobos, M. Calvino, M.L. Garcia-Buey, S. Garcia-Garzon, F. Gonzalez-Mateos, A. Gonzalez-Praetorius, J. Miquel, A. Bienvenido, T. Parra
Journal: Journal of Hepatology (2008)
Treatment of Pediculosis Ciliorum in an Infant
Authors: Francesco Ronchese
Journal: New England Journal of Medicine (1953)

PEDICULOSIS (infestation with Phthirus pubis or crab lice) involving the eyelashes and the edges of the eyelids is rare in the normal adult but less rare in the infant (Fig. 1), who is usually infested by direct passage of the lice from the axillary or chest hair (Fig. 2) of the parents or nurse or attendant. The lice are visible to the naked eye or can be seen with the help of common magnifying glasses.The therapeutic procedure is simple. The infant's head is held as firmly as possible with the help of assistants. In spite of batting eyelids, screams . . .
Limpet anaphylaxis: cross‐reactivity between limpet and house‐dust mite <i>Dermatophagoides pteronyssinus</i>
Authors: J. Azofra, M. Lombardero
Journal: Allergy (2003)

Background: Limpet is a mollusc that is frequently found along the shores of warm seas. Few allergic reactions to limpet have been described, and cross‐reactivity with house‐dust mites has not been established. Methods: We report five patients with anaphylactic reactions due to limpet ingestion. A limpet extract was prepared and skin prick tests (SPT), radioallergosorbent assays (RAST), sodium dodecylsulfate polyacrylamide gel electrophoresis (SDS‐PAGE), and IgE‐immunoblotting were performed. In order to evaluate cross‐reactivity, an immunoblotting inhibition assay with Dermatophagoides pteronyssinus was also done. Results: All patients were asthmatics sensitized to house‐dust mites. In each case, severe bronchospasm was evidenced, and three required mechanical ventilation. Positive SPT with limpet extract was found in the four patients tested. RAST showed specific IgE on each patient's sera. Immunoblotting showed several allergenic fractions with a wide molecular weight range (15–250 kDa). D. pteronyssinus inhibited IgE‐binding molecules above 50 kDa in the limpet extract, particularly one molecule of 75 kDa. Conclusions: We describe five patients with IgE‐mediated limpet allergy. Severe bronchospasm was the most important symptom. Cross‐reactivity with D. pteronyssinus was demonstrated.
Doppler ultrasound findings in healthy wrists and finger joints
Authors: L Terslev
Journal: Annals of the Rheumatic Diseases (2004)

<b>Objective:</b> To evaluate the presence of flow by Doppler ultrasound (DUS) in the wrist and finger joints (carpometacarpal 1 (CMC1), metacarpophalangeal (MCP), and proximal interphalangeal (PIP) joints) of healthy controls. <b>Methods:</b> Twenty seven healthy volunteers (15 women, 12 men; mean age 45 years, range 18–93) with a total of 324 joints were examined by DUS. The synovial vascularisation was determined by colour Doppler and the spectral Doppler resistive index (RI). Patients were only included if no synovitis was suspected at the clinical examination and the values for biochemical analysis were within the normal range. <b>Results:</b> We found colour pixels in 15 of the 27 examined wrist scans and in 8 of these a measurable RI. In the CMC1 joint, colour pixels were found in 11 of the 27 scans and in 9 of these a measurable RI. For the MCP joints, colour pixels were found in 10 out of 135 scans and in 3 of these a measurable RI. The mean RI for all three types of joints was 0.85 and the mean pixel fraction varied from 0.05 to 0.08. Only one PIP joint scan was found to have colour pixels and a flow with an RI of 0.67. <b>Conclusion:</b> Synovial vascularisation may be detected in healthy subjects using DUS. Newer US machines have higher Doppler sensitivity, and it is necessary to be able to distinguish normal from pathological synovial flow.
Visceral leishmaniasis (kala-azar)—the Bihar (India) perspective
Authors: P.K. Sinha, A. Ranjan, V.P. Singh, V.N.R. Das, K. Pandey, N. Kumar, N. Verma, C.S. Lal, D. Sur, B. Manna, S.K. Bhattacharya
Journal: Journal of Infection (2005)
Practical Management of the Allergic Child
Authors: Heinz J. Wittig
Journal: JAMA (1969)

<i>Practical Management of the Allergic Child</i>, by Vincent J. Fontana, represents a unique book. It does not try to compete with the wellknown standard textbooks in pediatric allergy, such as Glaser's<i>Allergy in Childhood</i>, or<i>The Allergic Child</i>edited by Speer, but merely intends to give practical advice to the pediatrician, internist, and general practitioner who deals with the day-by-day aspects of allergic illness in the young.<i>Practical Management of the Allergic Child</i>is a one-author book. This has the advantage of offering the reader a critical abstract of what worked best during a vast clinical experience, and does not confuse him with a great amount of conflicting ideas and contradictions between various investigators. Unfortunately, it also removes the check valve, inherent in a multiple-author book, which would prevent a work from going too far in any particular direction. For instance, it would have been better had Fontana left the
TOR Is Required for the Retrograde Regulation of Synaptic Homeostasis at the Drosophila Neuromuscular Junction
Authors: Jay Penney, Kazuya Tsurudome, Edward H. Liao, Fatima Elazzouzi, Mark Livingstone, Miranda Gonzalez, Nahum Sonenberg, A. Pejmun Haghighi
Journal: Neuron (2012)

SummaryHomeostatic mechanisms operate to stabilize synaptic function; however, we know little about how they are regulated. Exploiting Drosophila genetics, we have uncovered a critical role for the target of rapamycin (TOR) in the regulation of synaptic homeostasis at the Drosophila larval neuromuscular junction. Loss of postsynaptic TOR disrupts a retrograde compensatory enhancement in neurotransmitter release that is normally triggered by a reduction in postsynaptic glutamate receptor activity. Moreover, postsynaptic overexpression of TOR or a phosphomimetic form of S6 ribosomal protein kinase, a common target of TOR, can trigger a strong retrograde increase in neurotransmitter release. Interestingly, heterozygosity for eIF4E, a critical component of the cap-binding protein complex, blocks the retrograde signal in all these cases. Our findings suggest that cap-dependent translation under the control of TOR plays a critical role in establishing the activity dependent homeostatic response at the NMJ.Highlights•TOR is required for the ability of the NMJ to undergo homeostatic signaling•TOR acts in a retrograde manner•S6K acts downstream from TOR•TOR can induce a retrograde enhancement in neurotransmitter release
Bile acids exert negative feedback control on bile acid synthesis in cultured pig hepatocytes by suppression of cholesterol 7α-hydroxylase activity
Authors: Jaap Kwekkeboom, Hans M. G. Princen, Eline M. van Voorthuizen, Herman Jan M. Kempen
Journal: Hepatology (1990)

Feedback regulation of bile acid synthesis by its end products was studied in cultured hepatocytes of young weaned pigs. We previously showed that conversion of exogenous [ 14 C] cholesterol into bile acids was suppressed by addition of bile acids to the culture medium. In the present study, the effects of bile acids on bile acid mass production and cholesterol 7α-hydroxylase activity were examined. Mass production of bile acids was strongly inhibited by addition of taurocholic acid (50 and 100 μmol/L) to the culture medium. The inhibitory action was exerted specifically on activity of cholesterol 7α-hydroxylase because conversion of [ 14 C] 7α-hydroxycholesterol to bile acids by pig hepatocytes was not affected. Suppression of cholesterol 7α-hydroxylase activity after incubation of the hepatocytes with taurocholic acid was concentration- and time-dependent. Maximum suppression (−80%) was achieved after a 20 to 30 hr incubation of hepatocytes with 100 μmol/L of this bile acid. Decline of enzyme activity caused by 100 μmol/L taurocholic acid followed first-order kinetics with a half-life of 10 hr. Taurocholic acid had no direct effect on cholesterol 7α-hydroxylase activity in homogenates of hepatocytes as assessed by addition of the bile acid to the assay mixture. The effects of several other bile acids in a concentration of 100 μmol/L on cholesterol 7α-hydroxylase activity were examined in 48 hr incubations. Glycochenodeoxycholic and glycohyodeoxycholic acids, which are the major bile acids in pig bile, their unconjugated forms and also deoxycholic and cholic acid pronouncedly inhibited activity of the enzyme. In contrast, hyocholic acid almost failed to inhibit, whereas ursodeoxycholic acid was a weak inhibitor. It is concluded that bile acids, in physiological concentrations (i.e., as observed in portal blood), inhibit bile acid synthesis in cultured pig hepatocytes by suppression of cholesterol 7α-hydroxylase activity through a direct effect on the hepatocoyte. (HEPATOLOGY 1990;12:1209-1215).
Supporting Autonomy to Motivate Patients With Diabetes for Glucose Control
Authors: Geoffrey C Williams, Zachary R Freedman, Edward L Deci
Journal: Diabetes Care (1998)

We applied the self-determination theory of human motivation to examine whether patient perceptions of autonomy supportiveness (i.e., patient centeredness) from their diabetes care providers related to improved glucose control over a 12-month period.We conducted a prospective cohort study of patients with diabetes from a diabetes treatment center at a university-affiliated community hospital. Participants were 128 patients between 18 and 80 years of age who took medication for diabetes, had no other major medical illnesses, and were responsible for monitoring their glucose and taking their medications. The main outcome measure was a change in HbA1c values over the 12 months of the studyPatient perception of autonomy support from a health care provider related to a change in HbA1c values at 12 months (P < 0.05). Further analyses showed that perceived autonomy support from the staff related to significant increases in patient autonomous motivation at 12 months (P < 0.05); that increases in autonomous motivation related to significant increases in perceived competence (P < 0.05); and that increases in a patient's perceived competence related to significant reductions in their HbA1c values over 12 months (P < 0.001).The findings support the prediction of the self-determination theory that patients with diabetes whose health care providers are autonomy supportive will become more motivated to regulate their glucose levels, feel more able to regulate their glucose, and show improvements in their HbA1c values.
Myocardial Infarction After Exercise Test
Authors: John Naughton
Journal: JAMA (1976)

<h3>To the Editor.—</h3> I have read the article by Dr Lintgen, entitled "Death From Myocardial Infarction After Exercise Test With Normal Result" (235:837, 1976). The article is of intense interest because of the need to verify the hazards of exercise-stress testing. I must disagree, however, with both the title of the article and the electrocardiogram interpretation. Although not as diagnostic as many exercise electrocardiographic tracings, there is clearly upward ST displacement in aV<sub>R</sub>with delayed repolarization, as evidenced by ST changes in aV<sub>F</sub>. Further, the ST segments seen in V<sub>3</sub>, V<sub>4</sub>, and V<sub>5</sub>are definitely displaced downward with a delayed repolarization slope, and CM<sub>5</sub>as displayed is not of usual configuration. It is unfortunate that the baseline tracing is not included for comparison. However, as one who has worked in this difficult area for many years, I cannot accept the result as "normal" or
Adult Health: Services for the Chronically Ill and Aged
Authors: Frederic D. Zeman
Journal: JAMA (1967)

This worthwhile contribution to problems of pressing contemporary interest is handicapped by a vague title that hardly seems likely to provoke wide reader interest. The major emphasis seems to be on public health attitudes and methods rather than on the role of the practicing physician, who is belatedly beginning to appreciate the community rather than the individual approach to these areas. How the problems of chronic illness can be approached on a community basis is the theme of this book. The authors believe it is possible to develop constructive programs for chronic disease control. The text is divided into four parts, of which the first considers the prevention and early detection of chronic illness, professional and patient education, home and institutional care, rehabilitation services, and the care of the ambulatory chronically ill patient. Part two includes supporting services for an adult health program; part three discusses control programs for various
COMPETITION OF 19S AND 7S ANTIGEN RECEPTORS IN THE REGULATION OF THE PRIMARY IMMUNE RESPONSE
Authors: Claudia Henry, Niels K. Jerne
Journal: The Journal of Experimental Medicine (1968)

Prior to sheep red cells (SRC) mice were given 7S or 19S anti-SRC antibodies or mixtures of both. All 7S preparations suppressed the immune response. All 19S preparations enhanced the primary response, as measured by an up to 15-fold increase in the number of PFC per spleen. Results obtained with mixtures showed that 7S and 19S antibodies are competitive in their effect. The kinetics of the appearance of PFC in the mouse spleen after injection of SRC suggest that the depressive effect of 7S antibody simulates a reduction in SRC dose, whereas the enhancing effect of 19S antibody appears as a temporary increase in the rate at which PFC appear. Antibodies from one animal species are quite effective in another species.
The responses to surface wettability gradients induced by chitosan nanofilms on microtextured titanium mediated by specific integrin receptors
Authors: Jung Hwa Park, Christine E. Wasilewski, Noelia Almodovar, Rene Olivares-Navarrete, Barbara D. Boyan, Rina Tannenbaum, Zvi Schwartz
Journal: Biomaterials (2012)
Closing gaps in the human genome with fosmid resources generated from multiple individuals
Authors: Donald Bovee, Yang Zhou, Eric Haugen, Zaining Wu, Hillary S Hayden, Will Gillett, Eray Tuzun, Gregory M Cooper, Nick Sampas, Karen Phelps, Ruth Levy, V Anne Morrison, James Sprague, Donald Jewett, Danielle Buckley, Sandhya Subramaniam, Jean Chang, Douglas R Smith, Maynard V Olson, Evan E Eichler, Rajinder Kaul
Journal: Nature Genetics (2007)
Scientists find new disease: motivational deficiency disorder
Authors: Ray Moynihan
Journal: BMJ (2006)

Extreme laziness may have a medical basis, say a group of high profile Australian scientists, describing a new condition called motivational deficiency disorder (MoDeD).

The condition is claimed to affect up to one in five Australians and is characterised by overwhelming and debilitating apathy. Neuroscientists at the University of Newcastle in Australia say that in severe cases motivational deficiency disorder can be fatal, because the condition reduces the motivation to breathe.

Neurologist Leth Argos is part of the …
The Treatment of Renal Failure
Authors: Leonard B. Berman
Journal: JAMA (1982)

This slender volume lacks any statement from the editor telling us for whom the book is intended. The contents make it clear that it is suitable exclusively for nephrologists operating dialysis and transplant centers. Six of the eight chapters deal with the mechanics of treating renal failure, ie, vascular access, peritoneal dialysis, hospital and home hemodialysis, and renal transplantation. The remaining two chapters are reasonably complete and up-to-date discussions of acute and chronic renal failure. A moment of high humor is provided by the cover, which states that the book is essential reading for all physicians, surgeons, nursing staff, and administrators involved in any aspect of treating renal failure. Absurdities aside, Dr Castro has produced a competent volume that will be of interest to a relatively small group of physicians.
Abstract 2486: Plasma proteomic changes induced by effective chemopreventive ratios of N-3:N-6 fatty acids against MNU-induced mammary carcinogenesis of the rat.
Authors: Christine G. Skibinski, Henry J. Thompson, Arunangshu Das, Andrea Manni, Karam El-Bayoumy
Journal: Cancer Research (2013)

Abstract The development of sensitive, specific, and reliable biomarkers for early detection of breast cancer and the discovery of novel chemopreventive agents are two strategies with promising clinical applications. It has been postulated that the risk of breast cancer can be influenced by certain dietary compounds such as the type and amount of dietary fats ingested. We have shown that a diet high in an n-3:n-6 ratio (10:1 and 25:1), that provided 30% calories from fat (10% monounsaturated, 10% polyunsaturated, and 10% saturated fatty acids), significantly reduced rat mammary cancer induced by 1-methyl-1-nitrosourea(MNU). In the present study we used a proteomic approach to gain insights into the mechanisms of protection by a high n-3:n-6 ratio with the goal of identifying biomarkers that can be employed to monitor efficacy of chemopreventive agents. The plasma from six rats from each of three groups, a control group(n-3:n-6=1:1) and two groups fed a high n-3 diet(n-3:n-6=10:1 and 25:1) was pooled and submitted to the isobaric Tags for Relative and Absolute Quantitation(iTRAQ) method, which includes matrix-assisted laser desorption/ionization tandem mass spectroscopy(MALDITOF/TOF) to identify and quantify proteins that were regulated as a result of n-3 fatty acid supplementation. There were 148 proteins identified in our study with 95% confidence(unused score 1.3 or greater) by ProteinPilot 4.0. In plasma of rats fed 10:1 n-3:n-6, and 25:1 n-3:n-6 the number of proteins that met our criteria(p&amp;lt;0.05, error factor≤2) were 10 and 14 proteins, respectively. Our results illustrated that many proteins were modified in a manner consistent with chemoprevention. Validation of the iTRAQ by Western Blotting showed up-regulation of vitamin D binding protein and gelsolin postulated to have a tumor suppressive effect through modulation of inflammation and actin depolarization, respectively. We also observed that 14-3-3 sigma, a well known tumor suppressor in breast tissue, was increased in a ratio dependent fashion. In contrast, we observed down-regulation of alpha-1b-glycoprotein which has been reported to be elevated in the serum of breast cancer patients. These proteins may serve in future studies as candidate biomarkers in early detection and clinical chemoprevention trials with well-defined ratios of n-3:n-6 fatty acids. Support: Susan G. Komen Foundation(KG081632) Citation Format: Christine G. Skibinski, Henry J. Thompson, Arunangshu Das, Andrea Manni, Karam El-Bayoumy. Plasma proteomic changes induced by effective chemopreventive ratios of N-3:N-6 fatty acids against MNU-induced mammary carcinogenesis of the rat. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2486. doi:10.1158/1538-7445.AM2013-2486
Non-invasive ultrasonic measurement of the elastic properties of the human abdominal aorta
Authors: T. IMURA, K. YAMAMOTO, K. KANAMORI, T. MIKAMI, H. YASUDA
Journal: Cardiovascular Research (1986)

A new echo tracking device linked to real time ultrasonic B mode equipment was developed to measure non-invasively the elastic properties of the human abdominal aorta. Pulsatile diameter change and mean diameter of the abdominal aorta were measured in 61 subjects with this ultrasonic device. Strain and pressure-strain elastic modulus Ep were calculated from pulsatile diameter change, diameter, and pulse pressure obtained by the auscultatory method. Strain significantly decreased with age; 0.076(0.024) (mean(SD)) in group 1 (20 young adults below the age of 35 years); 0.048(0.024) in group 2 (21 middle aged subjects between the ages of 35 and 60 years); and 0.030(0.010) in group 3 (20 elderly subjects over the age of 60 years). Ep values were 0.99(0.34) X 10(5), 1.55(0.68) X 10(5), and 3.80(2.05) X 10(5) N X m-2 in groups 1, 2, and 3 respectively. Ep in group 3 was significantly higher than in groups 1 and 2. The regression equation relating Ep to age was Ep = (-0.72 + 0.058 X age) X 10(5) N X m-2 (r = 0.73). The Ep value and its age related increase agreed with the findings in postmortem arteries. The elastic properties of the abdominal aorta could, therefore, be determined non-invasively by this ultrasonic method.
Competence and performance in language acquisition
Authors: Mark Hale
Journal: Behavioral and Brain Sciences (1996)

Abstract The implications of Epstein et al.'s critical evaluation of much of the existing literature on L2-acquisition extends far beyond the domain they discuss. I argue that similar methodological clarification is urgently needed in analyses of the role of UG in L1-acquisition, as well as in discussions in such seemingly “distant” areas as the study of language change.
Peter Cardwell Elmes
Authors: Ian Campbell, Margaret Elmes, Owen Wade
Journal: BMJ (2004)

Former director Medical Research Council pneumoconiosis research unit, Llandough Hospital, south Wales, and Whitla professor of therapeutics and pharmacology Queen's University, Belfast (b 1921; q Oxford 1945; MBE, FRCP, FFOM), died from prostate cancer on 19 November 2003.​2003.
Exogenous Nurr1 gene expression in electrically-stimulated human MSCs and the induction of neurogenesis
Authors: Ji Sun Park, Han Na Yang, Dae Gyun Woo, Su Yeon Jeon, Hyun-Jin Do, Sun-Hyung Huh, Nam-Hyung Kim, Jae-Hwan Kim, Keun-Hong Park
Journal: Biomaterials (2012)