tbuckley/cabot-search huggingface dataset:
Bilateral Fine-Needle Administered Local Anaesthetic Nerve Block for Pain Control during TRUS-Guided Multi-Core Prostate Biopsy: A Prospective Randomised Trial
Authors: Rolf von Knobloch, Jost Weber, Zoltan Varga, Helmut Feiber, Axel Heidenreich, Rainer Hofmann
Journal: European Urology (2002)
LOW HEMOGLOBIN LEVELS IN WOMEN AS REVEALED BY BLOOD DONOR RECORDS
Authors: George W. Hervey
Journal: JAMA (1952)

In American Red Cross blood procurement records women constitute a minority of the donors represented. The greater response by men can be attributed largely to more intensive recruitment among male employee groups, to less fear of venipuncture, and to more widespread knowledge of the therapeutic uses of blood and its derivatives, gained while serving in the armed forces. Furnishing the stimulus for the present report, still another element of the disparity is the fact that on presenting themselves many more women than men are found to be unacceptable because of low hemoglobin levels. Previously unpublished information concerning the incidence of low hemoglobin levels can be derived from mass data pertaining to white persons who volunteered to contribute blood in the period January, 1948, to June, 1949, inclusive.<sup>1</sup>All ranged in age from 18 through 59. Shown in table 1 are figures on 239,191 persons (165,408 men and 73,783 women)
Elevation of an endogenous inhibitor of nitric oxide synthesis in experimental congestive heart failure
Authors: Qingping Feng, Xiangru Lu, A. J. Fortin, A. Pettersson, T. Hedner, R. L. Kline, J. M. O. Arnold
Journal: Cardiovascular Research (1998)

Objective: NG,NG-dimethylarginine (asymmetric dimethylarginine, ADMA) is an important endogenous substance with potent inhibitory actions on nitric oxide (NO) synthesis. The present study was designed to determine circulating ADMA levels and endothelium-dependent, NO mediated vasodilation in a rat model of congestive heart failure (CHF). Methods: CHF was induced in rats by coronary artery ligation. Sham-operated rats served as normal controls. Plasma ADMA was determined by high performance liquid chromatography with fluorescence detection. Glomerular filtration rate (GFR) and renal blood flow (RBF) were measured by the clearance of inulin and p-aminohippuric acid, respectively. Endothelial function of the aorta was assessed in an organ bath. Results: Plasma levels of ADMA in rats with CHF (0.94±0.05 μmol/l) were significantly increased compared with sham-operated controls (0.75±0.06 μmol/l, p<0.05). Plasma levels of ADMA was negatively correlated with GFR (r=−0.65, p<0.05). Decreased endothelium-dependent relaxation to acetylcholine in the aorta of CHF was completely restored by l-arginine (300 μM) (p<0.01) while endothelium-independent relaxation to nitroprusside was not altered. ADMA potently inhibited endothelium-dependent relaxation in thoracic aorta of normal and CHF rats. The effect of ADMA was completely antagonized by l-arginine in both groups (p<0.01). Moreover, l-arginine improved endothelium-dependent relaxation in CHF rats in the presence of ADMA. Conclusions: An endogenous NO synthesis inhibitor ADMA is increased in the circulation of rats with CHF. The increased plasma levels of ADMA may contribute to the decreased endothelium-dependent relaxation in CHF, which is restored by l-arginine, possibly by competitive antagonism of ADMA.
Large cell anaplastic lymphoma of the skin
Authors: A.C. FELLER, W. STERRY
Journal: British Journal of Dermatology (1989)

Large cell anaplastic lymphoma (LCAL) is a recently described entity recognized by its constant expression of the CD30 antigen and by its morphology. LCAL is classified as high grade malignant lymphoma. We report 10 patients with LCAL of the skin, three with primary LCAL and others in which it developed with cutaneous T-cell lymphoma, mainly mycosis fungoides. The immunophenotype in all but one of these cases, was that of activated T cells.
1211 AMINO ACID CHANGE IN THE POSITIONS ASSOCIATED WITH PROTEASE INHIBITORS RESISTANCE IS LESS FREQUENT IN GENOTYPE 3 THAN IN GENOTYPE 1 HCV NATURAL STRAIN
Authors: E. Messina, S. Bagaglio, M. Merli, H. Hasson, A. Smacchia, A. Lazzarin, C. Uberti-Foppa, G. Morsica
Journal: Journal of Hepatology (2013)
Vascularization in vivo caused by the controlled release of fibroblast growth factor-2 from an injectable chitosan/non-anticoagulant heparin hydrogel
Authors: Masanori Fujita, Masayuki Ishihara, Masafumi Simizu, Kiyohaya Obara, Toshiaki Ishizuka, Yoshio Saito, Hirofumi Yura, Yuji Morimoto, Bonpei Takase, Takemi Matsui, Makoto Kikuchi, Tadaaki Maehara
Journal: Biomaterials (2003)
THE OCCURRENCE OF URTICARIA AFTER SPECIFIC FEVERS
Authors: E. Ward
Journal: BMJ (1920)

MTRzBzicr r 27 -~~~~~~~~~~~~~~~~~~I tMDCLJURA 7(tested bv cotton-wool).If such should be detected, and if they correspond to definite root areas, meningeal tumour should be carefully considered.Also brachial " neuritis " of very long duration should lead to a careful consideration of the possibility of spinal meningeal tumour.Spinal meningeal tumour is a rare disease, but not so rare as is generally believed.Closer consideration of this affection-in the differential diagnosis at the early period of chronic spinal diseases would lead more frequently to its early recognition and to early successful operation.
Estimation of thyroxine distribution in man
Authors: J. T. Nicoloff, J. Thomas Dowling
Journal: Journal of Clinical Investigation (1968)

A group of 13 normal subjects were evaluated for their extrathyroidal thyroxine distribution. The method employed the measurement of the acute plasma disappearance of a thyroxine-131I tracer and its concomitant uptake into the liver and forearm. The analysis of these parameters allowed the theoretical construction of a four compartmental mathematical model system comprised of the plasma, extracellular fluid, hepatic, and extrahepatic thyroxine pools. The results of this analysis revealed that the exchange of thyroxine from the plasma into the hepatic and extrahepatic cellular fluid spaces appeared, in general, to be rapid, while the uptake into the extrahepatic tissues was relatively slow. The calculated distribution of thyroxine at equilibrium was estimated to be 14% in liver, 34% in extrahepatic tissues, and 26% each in the plasma and extracellular fluid pools in this group of normal subjects.
Abstract 837: Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells.
Authors: Aurelie Tchoghandjian, Claudia Jennewein, Ines Eckhardt, Krishna Rajalingam, Simone Fulda
Journal: Cancer Research (2013)

Abstract Since inhibitor of apoptosis (IAP) proteins can regulate additional signaling pathways beyond apoptosis, we investigated the effect of the Smac mimetic BV6, which antagonizes IAP proteins, on non-apoptotic functions in glioblastoma (GBM). Here, we identify non-canonical NF-κB signaling and a TNFα/TNFR1 autocrine/paracrine loop as critical mediators of BV6-stimulated migration and invasion of GBM cells. In addition to GBM cell lines, BV6 triggers cell elongation, migration and invasion in primary, patient-derived GBM cells at non-toxic concentrations, which do not affect cell viability or proliferation, and also increases infiltrative tumor growth in vivo underscoring the relevance of these findings. Molecular studies reveal that BV6 causes rapid degradation of cIAP proteins, accumulation of NIK, processing of p100 to p52, translocation of p52 into the nucleus, increased NF-κB DNA binding and enhanced NF-κB transcriptional activity. EMSA supershift shows that the NF-κB DNA binding subunits consist of p50, p52 and RelB further confirming activation of the non-canonical NF-κB pathway. BV6-stimulated NF-κB activation leads to elevated mRNA levels of TNFα and additional NF-κB target genes involved in migration (i.e. IL-8, MCP-1, CXCR4) and invasion (i.e. MMP9). Importantly, inhibition of NF-κB by overexpression of dominant-negative IκBα superrepressor prevents the BV6-stimulated cell elongation, migration and invasion. Similarly, specific inhibition of non-canonical NF-κB signaling by RNA interference-mediated silencing of NIK suppresses the BV6-induced cell elongation, migration and invasion as well as upregulation of NF-κB target genes. Intriguingly, pharmacological or genetic inhibition of the BV6-stimulated TNFα autocrine/paracrine loop by the TNFα-blocking antibody Enbrel or by knockdown of TNFR1 abrogates the BV6-induced cell elongation, migration and invasion. By demonstrating that the Smac mimetic BV6 at non-toxic concentrations promotes migration and invasion of GBM cells via non-canonical NF-κB signaling, our findings have Citation Format: Aurelie Tchoghandjian, Claudia Jennewein, Ines Eckhardt, Krishna Rajalingam, Simone Fulda. Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 837. doi:10.1158/1538-7445.AM2013-837
Adoptive transfer of CD8+ T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice
Authors: Guo-Xiang Yang, Zhe-Xiong Lian, Ya-Hui Chuang, Yuki Moritoki, Ruth Y. Lan, Kanji Wakabayashi, Aftab A. Ansari, Richard A. Flavell, William M. Ridgway, Ross L. Coppel, Koichi Tsuneyama, Ian R. Mackay, Eric M. Gershwin
Journal: Hepatology (2008)

We recently reported that mice with a T cell–restricted expression of a dominant negative form of transforming growth factor β receptor type II (dnTGFβRII) spontaneously develop autoimmune cholangitis that resembles human primary biliary cirrhosis (PBC), including antimitochondrial antibodies (AMAs) and extensive portal CD4+ and CD8+ lymphocytic infiltrates. On the basis of these data, we performed a series of experiments to determine whether the pathology was secondary to direct dnTGFβRII disruption of the liver and/or alternatively the appearance of autoreactive T cells. First, using dnTGFβRIIRag1−/− mice, we noted a normal hepatic and biliary structure. Hence, we performed a rigorous series of adoptive transfer studies, transferring Ly5.1+ unfractionated spleen cell CD4+ or CD8+ T cells from dnTGFβRII mice into B6/Rag−/− (Ly 5.2) recipients. In unmanipulated dnTGFβRII mice, there was a marked increase in CD4+ and CD8+ T cell biliary infiltrates with AMA. Indeed, B6/Rag−/− recipients of dnTGFβRII unfractionated cells develop features of liver disease similar to PBC, suggesting that splenic loss of self-tolerance alone is sufficient to cause disease in this model and therefore that there is no specific abnormality in the biliary targets required for appearance of disease. More importantly, adoptive transfer of CD8+ but not CD4+ T cells into B6/Rag−/− mice led to liver histopathology remarkably similar to PBC, emphasizing a prominent role for CD8 T cell–mediated pathogenesis. In contrast, B6/Rag−/− recipients of CD4+ T cells from dnTGFβRII mice predominantly developed inflammatory bowel disease associated with higher levels of serum interferon γ and tumor necrosis factor α. Conclusion: These data suggest that in this model of PBC, autoreactive CD8+ cells destroy bile ducts.
Computer Physician Order Entry
Authors: David B. Edwards
Journal: Annals of Internal Medicine (2004)

Letters20 April 2004Computer Physician Order EntryDavid B. Edwards, MDDavid B. Edwards, MDFrom Banner Desert Medical Center, Mesa, AZ 85202.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-8-200404200-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Kuperman and Gibson's review of computer physician order entry (CPOE) (1) was timely but cannot be generalized. Their concentration on the published medical literature, which predominantly represents academic and teaching institutions, neglected many physicians who practice in nonteaching hospitals. In fact, none of the studies cited involved a nonteaching, nonacademic hospital.As medical students and house officers, we learned and mentored methods of efficient rounding. With greater emphasis on relative value unit productivity, and subsequently on billing, doctors have become notoriously efficient in conducting hospital rounds. The successful and (more important) unsuccessful implementation of CPOE invariably affects ...References1. Kuperman GJ, Gibson RF. Computer physician order entry: benefits, costs, and issues. Ann Intern Med. 2003;139:31-9. [PMID: 12834316] LinkGoogle Scholar2. Chin T. Doctors pull plug on paperless system. American Medical News. 17 February 2003. Accessed at www.ama-assn.org/amednews/2003/02/17/bil20217.htm on 4 March 2004. Google Scholar Author, Article, and Disclosure InformationAffiliations: From Banner Desert Medical Center, Mesa, AZ 85202. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoComputer Physician Order Entry: Benefits, Costs, and Issues Gilad J. Kuperman and Richard F. Gibson Computer Physician Order Entry Barton M. Nassberg Computer Physician Order Entry Gilad J. Kuperman and Richard F. Gibson Metrics 20 April 2004Volume 140, Issue 8Page: 669KeywordsAttentionComputersHealth care qualityHospitalsMedical staff ePublished: 20 April 2004 Issue Published: 20 April 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Palliative Treatments of Last Resort: Choosing the Least Harmful Alternative
Authors: Timothy E. Quill, Barbara Coombs Lee, Sally Nunn
Journal: Annals of Internal Medicine (2000)

Comprehensive palliative care, as exemplified by many state-of-the-art hospice programs, is the standard of care for the dying. Although palliative care is very effective, physicians, nurses, patients, families, and loved ones regularly face clinically, ethically, legally, and morally challenging decisions throughout the dying process. This is especially true when terminally ill patients are ready to die in the face of complex, difficult-to-treat suffering and request assistance from their health care providers. Although physician-assisted suicide has received the most attention as a potential last-resort response, this practice remains illegal in the United States except in Oregon, and even there it is relatively infrequent. More commonly, decisions are made about accelerating opioid therapy for pain, forgoing life-sustaining therapy, voluntarily stopping eating and drinking, and administering terminal sedation in response to unacceptable suffering. The moral distinctions between these practices are critical to some but relatively inconsequential to others. This paper illustrates, through summaries of real clinical cases, how each of these practices might be used in response to patients in particular clinical circumstances, keeping in focus the patient's values as well as those of families, other loved ones, and health care providers. The challenge is to find the least harmful solution to the patient's problem without abandoning patients and their loved ones to unacceptable suffering or to acting in a more deleterious way on their own.
Chemical and Biologic Weapons — A Primer
Authors: Victor W. Sidel, Robert M. Goldwyn
Journal: New England Journal of Medicine (1966)

THE increasing development and stockpiling of chemical and biologic weapons have been well documented, and facts are available to all citizens.1 2 3 Because these agents injure, incapacitate and kill, and because their manufacture and possible use present grave ethical considerations, physicians in particular not only must be familiar with their existence and their properties but also must stand firm in questioning the moral and even practical justification of their use.HistoryThe origins of modern chemical and biologic warfare can be found in antiquity.4 Poisoned arrows, still used among some aborigines, were commonly employed in ancient Asia and Western Europe. Hannibal . . .
Could the Health Decline of Prehistoric California Indians be Related to Exposure to Polycyclic Aromatic Hydrocarbons (PAHs) from Natural Bitumen?
Authors: Sebastian K.T.S. Wärmländer, Sabrina B. Sholts, Jon M. Erlandson, Thor Gjerdrum, Roger Westerholm
Journal: Environmental Health Perspectives (2011)

The negative health effects of polycyclic aromatic hydrocarbons (PAHs) are well established for modern human populations but have so far not been studied in prehistoric contexts. PAHs are the main component of fossil bitumen, a naturally occurring material used by past societies such as the Chumash Indians in California as an adhesive, as a waterproofing agent, and for medicinal purposes. The rich archaeological and ethnohistoric record of the coastal Chumash suggests that they were exposed to multiple uptake pathways of bituminous PAHs, including direct contact, fume inhalation, and oral uptake from contaminated water and seafood.
Chronic actinic dermatitis responding to danazol
Authors: P. HUMBERT, C. DROBACHEFF, M. VIGAN, K. QUENCEZ, R. LAURENT, P. AGACHE
Journal: British Journal of Dermatology (1991)

We report an unusual case of chronic actinic dermatitis associated with α1‐antitrypsin deficiency and who responded well to treatment with danazol.
Association of Cancer With AIDS-Related Immunosuppression in Adults
Authors: Morten Frisch
Journal: JAMA (2001)

MMUNOSUPPRESSION ASSOCIATEDwith human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS) markedly increases the risk of Kaposi sarcoma (KS) and non-Hodgkin lymphoma (NHL). 1 These malignancies and invasive cervical cancer are the only AIDS-defining cancers in HIV-infected individuals. 2Other specific cancers also occur in excess, but the risk pattern depends on the geographic region and the HIV exposure group studied. 3,4In industrialized parts of the world, a high level of risk has been found for anal cancer 5 and Hodgkin disease, [6][7][8] and marginally significant increases were reported for seminoma, multiple myeloma, and brain cancer. 7,8We used data from the recently updated AIDS-Cancer Match Registry Study to investigate the cancer pattern in the years surrounding the time of AIDS diagnosis among 302834 adult persons with HIV/ AIDS (PWAs) in the United States.Specifically, we aimed at identifying cancers that are likely to be influenced by immunosuppression, distinguishing them from those occurring in excess among PWAs due to lifestyle-related exposures linked to cancer risk independently of immunosuppression. METHODSWe linked cancer data to 366034 PWAs from 11 areas, including the states of Connecticut, Florida, Illinois, Massa-chusetts, New Jersey, and New York, and the metropolitan areas of Atlanta, Los Angeles, San Diego, San Francisco, and Seattle.Commercially available software (AutoMatch versions 3.0 and 4.1; MatchWare Technologies Inc, Burtonsville, Md) was used to implement a probabilistic matching algorithm that
Polyploidy and Endoreduplication in Nonleukemic Patients
Authors: Carlos E. Nasjleti, James M. Walden, Herbert H. Spencer
Journal: New England Journal of Medicine (1965)

REISMAN, Zuelzer and Mitani1 described polyploidy and endoreduplication of chromosomes in a patient being treated for acute leukemia. They ascribed these abnormalities to a primary chromosomal disorder in the leukemic cells. In this case, no baseline chromosome studies were obtained, and the specific chemotherapeutic agent that the patient was receiving at the time of study was not mentioned.In a patient with acute leukemia reported by Bottura and Ferrari2 polyploidy and endoreduplication were noted in a single bone-marrow examination obtained while the patient was receiving 6-mercaptopurine. A chromosomal analysis showed the normal diploid number before treatment was started. They suggested . . .
The Human Cytochrome c Oxidase Assembly Factors SCO1 and SCO2 Have Regulatory Roles in the Maintenance of Cellular Copper Homeostasis
Authors: Scot C. Leary, Paul A. Cobine, Brett A. Kaufman, Guy-Hellen Guercin, Andre Mattman, Jan Palaty, Gillian Lockitch, Dennis R. Winge, Pierre Rustin, Rita Horvath, Eric A. Shoubridge
Journal: Cell Metabolism (2007)
Managing spinal cord compression and lung cancer
Authors: J K Webb
Journal: BMJ (1991)

treated initially by aspiration,' but their conclusion that the "finding of no pleural leak should avoid unnecessary tube drainage and permit early dis- charge, whereas had these patients been treated with an intercostal drain from the outset their hospital stay would inevitably be prolonged" is clearly not sufficient justification to purchase a flame ioniser as they suggest.Few people would drain all these patients from the outset-a trial aspiration followed by repeat radiograph the next day if the lung re-expanded would be more usual.
Portable Cholesterol Analyzers
Authors: Jeffrey L. Furst
Journal: JAMA (1990)

<h3>To the Editor.—</h3> Kaufman et al<sup>1</sup>reported the coefficient of variation of cholesterol on the Reflotron analyzers as being 13.3%. These results differ from those reported in the literature, including references cited by the authors of the<i>JAMA</i>study. The tabulation below presents the results of eight other studies compared with the study of Kaufman et al. The coefficients of variation varied between 1.1% and 5.7% in these studies vs 13.3% in that by Kaufman et al. We do not know why the results of Kaufman et al differ so dramatically from those in the other reports. It is possible that their study protocol may have differed from that recommended by the manufacturers. We have requested a copy of the protocol so that we can validate the results internally. We encourage workers to continue to evaluate our system. We are confident that the analytical performance of the Reflotron
Microsporosis due to M. canis
Authors: C. J. La Touche
Journal: BMJ (1952)

Microsporosis due to M. Canis in Schoolchildren and Domestic AnimalsIn spite of improved standards in hygiene and public health in modern times microsporosis among schoolchildren still occurs often enough to be a cause for anxiety to both public health and educational authorities.In some districts a periodic check-up on children attending school or living in institutions is sufficient to control its spread; in others such measures applied only to children are not sufficient.
Response to Open Peer Commentaries on “Do Researchers Have an Obligation to Actively Look for Genetic Incidental Findings?”
Authors: Catherine Gliwa, Benjamin E. Berkman
Journal: The American Journal of Bioethics (2013)

Click to increase image sizeClick to decrease image size Acknowledgments This article is not subject to U.S. Copyright Law. The opinions expressed in this article are those of the authors. No statement in this article should be construed as an official position of the National Human Genome Research Institute, National Institutes of Health, or Department of Health and Human Services.
Polyunsaturated fatty acids effect on serum triglycerides concentration in the presence of metabolic syndrome components. The Alaska-Siberia Project
Authors: Juan C. Lopez-Alvarenga, Sven O.E. Ebbesson, Lars O.E. Ebbesson, M. Elizabeth Tejero, V. Saroja Voruganti, Anthony G. Comuzzie
Journal: Metabolism (2009)
Effective measures to prevent child injuries could help save 1000 lives a year
Authors: J. Zarocostas
Journal: BMJ (2011)

Ministers and officials from 193 countries adopted a resolution at the annual World Health Assembly that identifies for the first time child injuries as a major threat to child survival and a neglected public health problem. They called for urgent action to prioritise prevention and care of child injuries in health programmes in developing countries.

The resolution by the assembly, the ruling body of the World Health Organization, specifically requests the head of WHO to establish public health policies and programmes for mitigating the consequences of …