Phenformin and Lactic Acidosis
Authors: STANLEY A. BLUMENTHAL
Journal: Annals of Internal Medicine (1976)

Comments and Correction1 May 1976Phenformin and Lactic AcidosisSTANLEY A. BLUMENTHAL, M.D., F.A.C.P., DAVID H. P. STREETEN, M.B., D.PHIL., F.R.C.P.STANLEY A. BLUMENTHAL, M.D., F.A.C.P.Search for more papers by this author, DAVID H. P. STREETEN, M.B., D.PHIL., F.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-5-615 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We wish to correct a statement that appeared in our recent "Letter" (Ann Intern Med84:55-56, 1976). In our discussion of a patient with phenformin-related lactic acidosis, we indicated that the increase in phosphofructokinase activity, and hence the increase in glycolytic production of lactic acid, was caused by a fall in cytosolic ATP concentration. This is probably not true. Current biochemical evidence suggests that intracellular ATP levels do not regulate glycolysis because they change very little, even under anoxic conditions, and that increases or decreases in phosphofructokinase activity are closely related to concordant changes in cytosolic AMP...Reference1. NEWSHOLMESTART EC: Regulation in Metabolism. London, John Wiley & Sons, 1973, pp. 105-132 Google Scholar1. WILLIAMSPALMER RJ: Farewell to phenformin for treating diabetes mellitus. Ann Intern Med 83:567-568, 1975 LinkGoogle Scholar2. WILANSKYHAHN DI: Modification of latent diabetes by short-term phenformin administration. Metabolism 16:199-203, 1967 CrossrefMedlineGoogle Scholar3. FALUDIBENDERSKYGERBER GGP: Functional hypoglycemia in early latent diabetes. Ann NY Acad Sci 148:868-874, 1968 CrossrefMedlineGoogle Scholar4. BERGERDOWNEYTRAISMAN SJH: Effect of phenformin on the cortisone glucose tolerance test. Ann NY Acad Sci 148:859-867, 1968 CrossrefMedlineGoogle Scholar5. ARKYABRAHAMSON RE: Insulin response to glucose in the presence of oral hypoglycemics. Ann NY Acad Sci 148:768-777, 1968 CrossrefMedlineGoogle Scholar6. LUKENSDOHANWOLCOTT FFM: Pituitary diabetes in the cat: recovery following phloridzin treatment. Endocrinology 32:475-487, 1943 CrossrefGoogle Scholar7. STOWERSBEWSHERBRACKENRIDGE JPR: Trial of chlopropamide in subclinical diabetes. Diabetes 11(suppl):127-130, 1962 MedlineGoogle Scholar8. WILANSKYSHOCHAT DG: The course of latent diabetes. Ann NY Acad Sci 148:848-858, 1968 CrossrefMedlineGoogle Scholar9. CRAWFORDBODE JH: Diabetes and the amplifier hypothesis. N Engl J Med 282:1266-1267, 1970 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STANLEY A. BLUMENTHAL, M.D., F.A.C.P.; DAVID H. P. STREETEN, M.B., D.PHIL., F.R.C.P.Affiliations: VA Hospital Department of Medicine State University of New York Upstate Medical Center Syracuse, NY 13210 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug Interactions with Antimicrobial AgentsDrug Interactions with Agents Used to Treat Endocrine DisordersCIRRHOSIS IN SOUTH WALESPHENFORMIN-INDUCED LACTICACIDOSIS PRECIPITATED BY TETRACYCLINELactic acidosis in biguanide-treated diabeticsDiabetes MellitusInsulin, glucagon and oral hypoglycaemic drugsPhenformin in Diabetes MellitusLUBOMIR J. VALENTA, M.D. 1 May 1976Volume 84, Issue 5Page: 615-616KeywordsAdenosine monophosphateAdenosine triphosphateAttentionFallsLactic acidLactic acidosis ePublished: 1 December 2008 Issue Published: 1 May 1976 PDF downloadLoading ...