tbuckley/cabot-search huggingface dataset:
30-Month Stability of Personality Disorder Diagnoses in Depressed Outpatients
Authors: Tova Ferro, Daniel N. Klein, Joseph E. Schwartz, Karen L. Kasch, Julie B. Leader
Journal: American Journal of Psychiatry (1998)

This study examined the 30-month stability of axis II conditions.One hundred eight depressed outpatients received comprehensive, semistructured personality disorder assessments at baseline and at follow-up.The diagnostic stability of personality disorders ranged from low to moderate at the categorical level and was generally moderate at the dimensional level. Most disorders exhibited good discriminant validity, in that the association between a disorder at baseline and at follow-up was greater than the associations between that disorder at baseline and the other 11 axis 11 disorders at follow-up. Two variables, sex and lifetime history of substance abuse or dependence, were significantly related to change in level of personality disorder features over time.Personality disorders have low to moderate stability over a 30-month period in depressed outpatients.
The α(1,3)fucosyltransferases FucT-IV and FucT-VII Exert Collaborative Control over Selectin-Dependent Leukocyte Recruitment and Lymphocyte Homing
Authors: Jonathon W Homeister, Aron D Thall, Bronia Petryniak, Petr Malý, Clare E Rogers, Peter L Smith, Robert J Kelly, Kevin M Gersten, Sanaz W Askari, Guiying Cheng, Glennda Smithson, Rory M Marks, Anup K Misra, Ole Hindsgaul, Ulrich H von Andrian, John B Lowe
Journal: Immunity (2001)
Book Review Ascites and Renal Dysfunction in Liver Disease: Pathogenesis, Diagnosis, and Treatment Second edition. Edited by Pere Ginès, Vicente Arroyo, Juan Rodés, and Robert W. Schrier. 450 pp., illustrated. Malden, Mass., Blackwell, 2005. $174.95. 1-405-11804-0
Authors: Nathan M. Bass
Journal: New England Journal of Medicine (2006)
Harry Alexander Isenberg
Authors: L. Isenberg, D. Isenberg
Journal: BMJ (2010)

Harry Alexander Isenberg, son of Jewish immigrants in London’s East End, left school at 14 and after learning short hand and typing at Clark’s then Pitman’s college, was apprenticed to a cloth merchant. He became inspired to become a doctor, and, unbeknown to his family, he left his job and took a correspondence course and matriculated by studying in Hackney …
Iron chelation therapy in sickle cell anemia
Authors: Alan Cohen, Elias Schwartz
Journal: American Journal of Hematology (1979)

Abstract Iron stores, ascorbic acid levels, and urinary excretion of iron in response to deferoxamine (DFO) were studied in nine patients with sickle cell anemia who had received 8–55 liters of red blood cells. Ferritin levels ranged from 2, 168 to 6,300 ng/ml and were elevated even in patients who had normal serum iron concentrations. Leukocyte ascorbic acid levels were low in three patients. Urinary iron excretion in response to 2.0 gm DFO administered as a 12‐hour subcutaneous infusion after ascorbic acid supplementation was 13–39 mg/24 hours. With this method of DFO therapy daily, urinary iron excretion would exceed transfusional iron accumulation in eight of nine patients. Following the intramuscular injection of 0.75 gm DFO, urinary iron excretion was 5–16 mg/24 hours. Iron excretion would exceed iron accumulation in only one of nine patients with this method of DFO therapy. Urinary iron excretion in response to 1.5 gm DFO infused intravenously in 18 hours after ascorbic acid supplementation was 11–38 mg/24 hours. In six regularly transfused but nonchelated patients iron excretion in response to intravenous DFO had increased 46–107%, in comparison with previous studies 15–22 months before. These data indicate that negative iron balance can be obtained in regularly transfused patients with sickle cell anemia by the use of overnight subcutaneous infusions of DFO. Urinary iron excretion in response to DFO should be evaluated periodically in appropriate patients with sickle cell anemia to determine the proper time for the institution of chelation therapy.
NHS cuts mean 400 less per person in England over next four years
Authors: Z. Kmietowicz
Journal: BMJ (2010)

<h3>Abstract</h3> The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); host cell entry by this virus relies on the interaction between the receptor-binding domain (RBD) of its spike glycoprotein and the angiotensin-converting enzyme 2 (ACE2) receptor on cell membranes. In addition to serving as a receptor for SARS-CoV-2, ACE2 was originally discovered as a protective factor in the renin–angiotensin system (RAS) that catalyses the degradation of angiotensin II (Ang II) to Ang 1-7, which is involved in multiple organ pathology. Recent genetic and clinical studies reported that ApoE4 expression is associated with increased susceptibility to SARS-CoV-2 infection and the development of severe COVID-19, but the underlying mechanism is currently unclear. In the present study, by using immunofluorescence staining, molecular dynamics simulations, proximity ligation assay (PLA) and coimmunoprecipitation (Co-IP) combined with a biolayer interferometry (BLI) assay, we found that ApoE interacts with both the spike protein and ACE2 but does not show obvious isoform-dependent binding effects. These data suggest that ApoE4 increases SARS-CoV-2 infectivity in a manner that may not depend on differential interactions with the spike protein or ACE2. Importantly, further immunoblotting and immunofluorescence staining results showed that ApoE4 significantly downregulates ACE2 protein expression <i>in vitro</i> and <i>in vivo</i> and subsequently decreases the conversion of Ang II to Ang 1-7, which could worsen tissue lesions; these findings provide a possible explain by which ApoE4 exacerbates COVID-19 disease.
Parting Company: Understanding the Loss of a Loved One. The Caregiver's Journey
Authors: Charles E. Schwartz
Journal: Annals of Internal Medicine (2000)

Medical Writings: Book Notes3 October 2000Parting Company: Understanding the Loss of a Loved One. The Caregiver's JourneyCharles E. Schwartz, MDCharles E. Schwartz, MDMontefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York. (Schwartz)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-7-200010030-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Pearson C, Stubbs ML. 336 pages. Seattle: Seal Pr; 1999. $18.95. ISBN 1580050190. Order phone 800-754-0271.Field of medicine: Palliative care.Format: Softcover book.Audience: Physicians and health professionals in palliative care, trainees, and families of patients.Purpose: To present the perspective of families and caregivers and their experiences with caring for the dying.Content: The opening chapter provides a conceptual framework on death and dying and a historical overview of the evolving role of caregivers. Most of the book consists of detailed first-hand accounts of families caring for dying relatives, from diagnosis to bereavement. It includes interviews with a ... Author, Article, and Disclosure InformationAffiliations: Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York. (Schwartz) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 October 2000Volume 133, Issue 7Page: 572KeywordsCaregiversEmotionsEnd of life careHealth careHealth care facilitiesHealth care providersNursesPalliative carePatient advocacySoftware tools ePublished: 3 October 2000 Issue Published: 3 October 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Refractory auto-inflammatory syndrome associated with digenic transmission of low-penetrance tumour necrosis factor receptor-associated periodic syndrome and cryopyrin-associated periodic syndrome mutations
Authors: I Touitou, C Perez, B Dumont, L Federici, C Jorgensen
Journal: Annals of the Rheumatic Diseases (2006)

Two dominant periodic fevers, tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) and cryopyrin-associated periodic syndrome (CAPS), are prominent auto-inflammatory disorders. Mutations in the 55 kDa TNF receptor superfamily 1A gene ( TNFRSF1A ) and in the cold-induced auto-inflammatory syndrome 1 gene ( CIAS1 ) were recently associated with TRAPS1 and CAPS,2 respectively. Following publications describing the efficacy of etanercept (enbrel), a recombinant human TNF receptor 1B fusion protein in patients with TRAPS3 and anakinra (kineret), a recombinant human interleukin-1 (IL1)-receptor antagonist, in patients with CAPS,4 targeted biotherapies have been repeatedly and successfully given for these two conditions.

Our proband (fig 1) is a 36-year-old French woman who presented with rashes of urticaria and oedema precipitated by exposure to heat and water. These rashes, lasting a …
Identifying patients at risk for thromboembolism. Use of 125I-labeled fibrinogen in patients with acute myocardial infarction
Authors: N. Cristal
Journal: JAMA (1976)

Fibrinogen labeled with iodine 125 was used to detect deep vein thrombosis (DVT) in 35 patients during their course and convalescence from acute myocardial infarction. Clinical status was assessed and scored with the use of a modified coronary prognostic index. According to the prognostic scores, patients were allocated to one of two groups. Of 27 patients in good clinical condition, DVT developed in only one patient, whereas thromboembolic complications occurred in seven of eight patients who were severely ill--a highly significant difference. Prophylactic anticoagulation is advisable in patients at risk.
Asthma symptoms in Hispanic children and daily ambient exposures to toxic and criteria air pollutants.
Authors: Ralph J Delfino, Henry Gong, William S Linn, Edo D Pellizzari, Ye Hu
Journal: Environmental Health Perspectives (2002)

Although acute adverse effects on asthma have been frequently found for the U.S. Environmental Protection Agency's principal criteria air pollutants, there is little epidemiologic information on specific hydrocarbons from toxic emission sources. We conducted a panel study of 22 Hispanic children with asthma who were 10-16 years old and living in a Los Angeles community with high traffic density. Subjects filled out symptom diaries daily for up to 3 months (November 1999 through January 2000). Pollutants included ambient hourly values of ozone, nitrogen dioxide, sulfur dioxide, and carbon monoxide and 24-hr values of volatile organic compounds (VOCs), particulate matter with aerodynamic diameter < 10 microm (PM10, and elemental carbon (EC) and organic carbon (OC) PM10 fractions. Asthma symptom severity was regressed on pollutants using generalized estimating equations, and peak expiratory flow (PEF) was regressed on pollutants using mixed models. We found positive associations of symptoms with criteria air pollutants (O3, NO2, SO2, PM10), EC-OC, and VOCs (benzene, ethylbenzene, formaldehyde, acetaldehyde, acetone, 1,3-butadiene, tetrachloroethylene, toluene, m,p-xylene, and o-xylene). Selected adjusted odds ratios for bothersome or more severe asthma symptoms from interquartile range increases in pollutants were, for 1.4 ppb 8-hr NO2, 1.27 [95% confidence interval (CI), 1.05-1.54]; 1.00 ppb benzene, 1.23 (95% CI, 1.02-1.48); 3.16 ppb formaldehyde, 1.37 (95% CI, 1.04-1.80); 37 microg/m3 PM10, 1.45 (95% CI, 1.11-1.90); 2.91 microg/m3 EC, 1.85 (95% CI, 1.11-3.08); and 4.64 microg/m3 OC, 1.88 (95% CI, 1.12-3.17). Two-pollutant models of EC or OC with PM10 showed little change in odds ratios for EC (to 1.83) or OC (to 1.89), but PM10 decreased from 1.45 to 1.0. There were no significant associations with PEF. Findings support the view that air toxins in the pollutant mix from traffic and industrial sources may have adverse effects on asthma in children.
Plasma Homocysteine Is not Increased in Microalbuminuric Patients With Type 2 Diabetes Without Clinical Cardiovascular Disease
Authors: José-Miguel González-Clemente, Ramon Deulofeu, Joan Mitjavila, Gloria Galdon, Emilio Ortega, Assumpta Caixàs, Gabriel Giménez-Pérez, Didac Mauricio
Journal: Diabetes Care (2002)

Although mild hyperhomocysteinemia (MHH) has been considered as an independent risk factor for cardiovascular disease (CVD) (1,2), some investigators have cast doubts about this statement (2–4). Subjects with type 2 diabetes and microalbuminuria (MA) are particularly at risk of developing CVD. In these subjects, there is some controversy as to whether total plasma homocysteine (tHcy) levels are increased (5–7) or not (8–11). Usually, these studies, which include subjects with and without CVD, do not take into account this variable when analyzing their results. It is well known that there is a positive relationship between the presence of CVD and MA (12). In addition, CVD itself is associated with MHH (1,2). We hypothezised that studies that found an increase in tHcy levels in subjects with MA did not take into account the presence of a preexisting CVD as a confounding variable. Therefore, as subjects with type 2 diabetes and MA have a higher prevalence of preexisisting CVD, higher values of tHcy could be expected as a result of CVD and not because of MA.

To test this hypothesis, we studied 93 subjects with type 2 diabetes (55 with normoalbuminuria and 38 with MA) and 86 nondiabetic control subjects matched for age and sex, all of whom were recruited at a primary care center. The exclusion criteria were: age  85 years, serum creatinine >1.4 mg/dl, uncontrolled hypertension (systolic >160 mmHg and/or diastolic >95 mmHg), congestive heart failure, major invalidating disease, pregnancy, …
Severe Hypertension due to Autonomic Dysreflexia
Authors: S. J. Pelligra
Journal: JAMA (1986)

<h3>To the Editor.—</h3> I found the article entitled "Hypertensive Emergencies and Urgencies"<sup>1</sup>interesting and informative. I wish to point out that the authors neglected to mention one very important, albeit unusual, entity. Autonomic dysreflexia, or hyperreflexia, is a common hypertensive emergency in the injured patient with a spinal cord lesion above the T-7 level. It is a syndrome characteristically associated with the sudden onset of hypertension, headache, bradycardia, sweating, flushing, dilated pupils, and blurred vision and has been reported to occur in up to 85% of quadriplegic patients. Autonomic dysreflexia results from increased reflex activity within the nervous system precipitated by noxious stimuli below the level of injury, most often bladder distention. It is at times associated with other abnormal medical conditions including deep venous thrombosis, ingrown toenails, pressure sores, and fecal impaction. Treatment of the associated hypertension is important since seizures and cerebral hemorrhage have been reported. Usually
Hepatic Radiation Injury Mimicking a Metastasis on Positron-Emission Tomography/Computed Tomography in a Patient with Esophageal Carcinoma
Authors: Eithne M. DeLappe, Mylene T. Truong, John F. Bruzzi, Stephen G. Swisher, Eric M. Rohren
Journal: Journal of Thoracic Oncology (2009)
Long-Term Follow-Up of Patients With Short QT Syndrome
Authors: Carla Giustetto, Rainer Schimpf, Andrea Mazzanti, Chiara Scrocco, Philippe Maury, Olli Anttonen, Vincent Probst, Jean-Jacques Blanc, Pascal Sbragia, Paola Dalmasso, Martin Borggrefe, Fiorenzo Gaita
Journal: Journal of the American College of Cardiology (2011)
Certifying death in infancy.
Authors: M J Scott
Journal: BMJ (1984)

Relief of pain in terminal cancer * Ascertain the nature and source of pain.* Plan a prophylactic four hourly oral drug routine and prevent pain developing.* Maintain treatment bN, mouth for as long as possible.* Use morphine as the drug of choice in oral treatment; diamorphine may be preferred for parenteral administration.* Disregard fears of tolerance and addiction.* If oral analgesics fail to relicve pain explore other resources, nerve blocks, radiotherapy.
Human T-Cell Lymphotropic Viruses: Syncytia Formation
Authors: Lionel Resnick
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intravenous gamma globulin decreases platelet‐associated IgG and improves transfusion responses in platelet refractory states
Authors: Zella R. Zeigler, Richard K. Shadduck, Craig S. Rosenfeld, Alan Winkelstein, Donna Przepiorka, Joseph E. Kiss, Rene J. Duquesnoy, Marilyn Marrari
Journal: American Journal of Hematology (1991)

Abstract In an attempt to improve platelet transfusion responses, intravenous immunoglobulin (IV‐IgG) was administered to 19 patients who were refractory to random and best available HLA‐matched platelets. A response to IV‐IgG was defined as two or more successive transfusions of HLA‐matched products that provided recoveries greater than 30%. Thirteen of 19 (68%) patients responded to therapy at a median time of 7 days after initiation of IV‐IgG (range = 2–17). Baseline platelet associated IgG levels (PaIgG) were elevated in both the responders (61.6 ± 76.2) (mean ± SD) and the non‐responders (47.0 ± 46.3 fg/plt). Post‐therapy, PaIgG levels remained unchanged in the nonresponders but were decreased significantly (p = 0.05) to 11.1 ± 6.2 fg/plt in the responders. The latter levels were similar to those (11.6 ± 8.2 fg/plt) measured in a series of 36 transfusion responsive patients. This apparent decline in PaIgG was not explained by differences in lymphocytotoxic antibodies (LCT‐Ab) after therapy. Moreover, a high degree of alloimmunization was associated with a poorer response to IgG. Only two of eight patients with LCT panel‐reactive antibody (PRA) of &gt; 85% were responders. By contrast, improved transfusion outcomes were seen uniformly in patients with PRA ≦ 85%. Improved recoveries were obtained using LCT‐Ab compatible but not incompatible platelets. The median increment (% predicted) with compatible platelets before therapy was 6.0 ± 9.9 (SD). Post‐IgG, median recoveries were 37.0 ± 31.2 percent, P &lt; 0.001. These findings suggest that IV‐IgG may alter destructive mechanisms that affect the survival of compatible platelets in refractory patients.
Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines.
Authors: F O Nestle, L A Turka, B J Nickoloff
Journal: Journal of Clinical Investigation (1994)

Local activation of T lymphocytes is regarded as an important immunological component of psoriatic skin lesions. Within psoriatic plaques (PP) there are large numbers of dermal dendritic cells (DDCs) immediately beneath the hyperplastic epidermis surrounded by T cells. In this study we investigated the ability of DDCs isolated from PP skin to support immune responses to resting peripheral blood T cells. For comparison, other dendritic cells were obtained from blood of the same psoriatic patients, as well as DDCs from skin of normal healthy individuals (designated NN skin). All dendritic cells studied had high surface expression of HLA-DR, B7, and lymphocyte function associated antigen-1 molecules. T cell proliferative responses and cytokine production profiles to these various dendritic cells were measured in the absence and presence of PHA or bacterial-derived superantigens. In the absence of exogenous mitogens, PP skin-derived DDCs were much more effective stimulators of spontaneous T cell proliferation compared with either psoriatic blood-derived or NN skin-derived dendritic cells. Antibody blocking studies revealed involvement of HLA-DR, B7, and lymphocyte function associated antigen-1 on PP skin-derived DDCs. Cytokine profiles revealed that in the absence of exogenous stimuli PP skin-derived DDCs mediated a T cell response with high levels of IL-2 and IFN-gamma, but not IL-4 or IL-10. NN skin-derived DDCs produced a similar qualitative response, but quantitative amounts of all cytokines measured were lower. Upon addition of PHA or superantigens, both PP skin-derived and NN skin-derived DDCs mediated high levels of IL-2 and IFN-gamma production, with induction of IL-4 particularly evident for PHA reactions. Addition of conditioned medium from psoriatic dermal fragments did not enhance the autostimulatory capacity of blood-derived dendritic cells. These findings highlight the potent autostimulatory potential of PP skin-derived DDCs and suggest an important immunological contribution for these previously overlooked cell types contained within lesional skin sites.
World Bank warns of financial crises in healthcare systems
Authors: John Zarocostas
Journal: BMJ (2006)

Faced with growing levels of disease from the spread of HIV and AIDS and spiralling costs, healthcare systems in developing countries risk sliding into financial crises unless governments usher in reforms. This is the warning given in a World Bank report.

International donors must deliver on their promises and boost aid to meet the health needs of the world's poorest people, concludes the …
Wyman's Method.
Authors: J. N. McCormack
Journal: JAMA (1898)

State Board of Health of Kentucky, Executive Office. Bowling Green, Ky., May 2, 1898. <h3>To the Editor:</h3> —In the April 1 number of "Health Reports," published by the United States Marine-Hospital Service, the statement was officially made that, during the recent epidemic of smallpox at Middlesboro, national aid was sent to this State at the request of this Board and of Governor Bradley, and that the representative of that Service found the methods of this Board inefficient. As the epidemic was practically under control at the time of the unwarranted interference of this Service, and as their interference was wholly uninvited, I at once wrote the Supervising Surgeon-General asking that the false and unjust statements be corrected. As he has declined to make this correction, and as this Bureau is the chief obstacle to the enactment of efficient national legislation for the protection of the public health interests of the