Fatal Massive Hepatic Necrosis in Cytomegalovirus Mononucleosis
Authors: NEIL H. SHUSTERMAN
Journal: Annals of Internal Medicine (1978)

Brief Reports1 June 1978Fatal Massive Hepatic Necrosis in Cytomegalovirus MononucleosisNEIL H. SHUSTERMAN, B.S., CHRIS FRAUENHOFFER, M.D., M. DEAN KINSEY, M.D.NEIL H. SHUSTERMAN, B.S.Search for more papers by this author, CHRIS FRAUENHOFFER, M.D.Search for more papers by this author, M. DEAN KINSEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-6-810 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCytomegalovirus Mononucleosis is an acute febrile illness characterized by atypical lymphocytosis (1). The clinical picture strikingly resembles infectious mononucleosis with generalized malaise and splenomegaly. Persistently negative heterophil-antibody tests are an important laboratory finding in distinguishing this syndrome from Epstein-Barr virus-induced infectious mononucleosis.Hepatic involvement is a common finding in cytomegalovirus mononucleosis as manifested by mild hepatomegaly, consistent increases in serum transaminase activity, and variable elevation of serum alkaline phosphatase and bilirubin. We present here a case of fatal massive hepatic necrosis in a patient with cytomegalovirus mononucleosis.A 33-year-old previously healthy man had a 2-week history of fever, malaise, night...References1. KLEMOLA E: Further studies on cytomegalovirus mononucleosis in previously healthy individuals. Acta Med Scand 182:311-322, 1967 CrossrefMedlineGoogle Scholar2. BONKOWSKYLEEKLATSKIN HRG: Acute granulomatous hepatitis. Occurrence in cytomegalovirus mononucleosis. JAMA 233:1284-1288, 1975 CrossrefMedlineGoogle Scholar3. IIHIZAWAKATSUSE KKR: Generalized cytomegalic inclusion disease presenting an infectious mononucleosis syndrome (so-called cytomegalo-virus mononucleosis) in a previously healthy adult—an autopsy study. Acta Pathol Jpn 22:723-737, 1972 MedlineGoogle Scholar4. RAKALAMOSLEYREDEKER JJA: The role of hepatitis A virus in fulminant viral hepatitis (abstract). Gastroenterology 69:854, 1975 Google Scholar5. STERN H: Isolation of cytomegalovirus and clinical manifestations at different ages. Br Med J 1:665-669, 1968 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Thomas Jefferson University Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCytomegalovirus Hepatitis in Immunocompetent and Immunocompromised HostsCytomegalovirus Hepatitis in an Immunocompetent Patient: A Cause of Fever of Unknown OriginCytomegalovirus infection after liver transplantationEpstein-Barr Virus and Cytomegalovirus Infections of the LiverViral Hepatitis Non: B, C, D and Acute and Acute on Chronic Liver FailureCytomegalovirus hepatitis after bone marrow transplantation: An autopsy study with clinical, histologic and laboratory correlatesA Practical Review of Cytomegalovirus in Gastroenterology and HepatologyHepatobiliary Tract InfectionsHepatitis due to Epstein–Barr virus and cytomegalovirus: clinical features and outcomesA Case Treated with Extracorporeal Membrane Oxygenation for Disseminated Cytomegalovirus Infection after Liver TransplantationCytomegalovirus-Induced Hepatitis in an Immunocompetent PatientCytomegalovirus infection-associated fulminant hepatitis in an immunocompetent adult requiring emergency living-donor liver transplantation: report of a caseOther Hepatitis VirusesFulminant Hepatitis in Children: Evidence for an Unidentified Hepatitis VirusCutaneous Metastasis of Hepatocellular Carcinoma. 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Part IICytomegalovirus hepatitis: Evidence for direct hepatic viral infection using monoclonal antibodiesLiver biopsy interpretation in hepatitisL'infection à cytomégalovirus chez les adultes sains. Etude clinique, anatomopathologique, hépatique et virologique de six observationsJaundice due to bacterial infection 1 June 1978Volume 88, Issue 6Page: 810-812KeywordsAminotransferasesBilirubinEpstein-Barr virusFeversHepatomegalyNecrosisPhosphatasesResearch laboratoriesSplenomegaly Issue Published: 1 June 1978 PDF DownloadLoading ...