Functioning Islet Cell Adenoma with a Note about Leucine Sensitivity
Authors: A. EVAN OVERSTREET
Journal: Annals of Internal Medicine (1961)

Case Reports1 December 1961Functioning Islet Cell Adenoma with a Note about Leucine SensitivityA. EVAN OVERSTREET, M.D., JOSEPH J. RUPP, M.D., F.A.C.P.A. EVAN OVERSTREET, M.D.Search for more papers by this author, JOSEPH J. RUPP, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-6-998 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe occurrence of hypoglycemia as a result of excessive insulin production by islet cell tumors of the pancreas is well documented (1, 2). However, the demonstration of the tumor preoperatively is difficult since the pancreatic lesion is usually small and rarely produces symptoms because of its position. Nor do lowered blood sugar levels necessarily mean functioning islet cell tumor, inasmuch as hypoglycemia is a manifestation of diseases such as adrenal insufficiency, pituitary failure, or some large sarcomas (3) and also occurs in the absence of demonstrable lesions in children with idiopathic hypoglycemia (4), in adults with functional hypoglycemia (5), and...References1. WILLEBRANDSGROEN AFJ: Determination of serum insulin by the rat diaphragm method. Diabetes 5: 378, 1956. CrossrefMedlineGoogle Scholar2. YALOWBERSON RSSA: Immunoassay of endogenous plasma insulin in man. J. Clin. Invest. 39: 1157, 1960. CrossrefMedlineGoogle Scholar3. SELLMANPERKOFFNULLKIMMELTAYLOR JCGTFCJRFH: Hypoglycemia associated with massive intra-abdominal mesothelial-cell sarcoma. New Engl. J. Med. 260: 847, 1959. CrossrefMedlineGoogle Scholar4. MCQUARRIE I: Idiopathic spontaneously occurring hypoglycemia in infants. Amer. J. Dis. Child. 87: 399, 1954. Google Scholar5. CONNSELTZER JWHS: Spontaneous hypoglycemia. Amer. J. Med. 19: 460, 1955. CrossrefMedlineGoogle Scholar6. BERRY MG: Tobacco hypoglycemia. Ann. Intern Med. 50: 1149, 1959. LinkGoogle Scholar7. COCHRANEPAYNESIMPKISSWOOLF WAWWMJLI: Familial hypoglycemia precipitated by amino acids. J. Clin. Invest. 35: 411, 1956. CrossrefMedlineGoogle Scholar8. MARRACKMARKSROSE DVFC: A leucine sensitive insulin-secreting tumour. Lancet 2: 1329, 1960. CrossrefMedlineGoogle Scholar9. LANDAULEVINEHERTZ BRHJR: Prolonged glucagon administration in a case of hyperinsulinism due to islet-cell carcinoma. New Engl. J. Med. 259: 286, 1958. CrossrefMedlineGoogle Scholar10. DIGEORGE AM: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: A. EVAN OVERSTREET, M.D.; JOSEPH J. RUPP, M.D., F.A.C.P.Affiliations: Philadelphia, PennsylvaniaFrom the Department of Medicine and the Division of Endocrine and Cancer Research, The Jefferson Medical College of Philadelphia, 1025 Walnut Street, Philadelphia 7, Pennsylvania.Requests for reprints should be addressed to Joseph J. Rupp, M.D., The Jefferson Medical College of Philadelphia, 1025 Walnut Street, Philadelphia 7, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTumoren des PankreasDie spontanen HypoglykämienClinical and biochemical studies in patients with functioning islet cell tumorsLeucine-induced hypoglycemiaThe Phenomenon of Leucine Sensitivity* 1 December 1961Volume 55, Issue 6Page: 998-1001KeywordsAdenomasEpileptic seizuresGlucagonHypoglycemiaInsulinLesionsLeucinePancreasResearch laboratoriesSarcoma ePublished: 1 December 2008 Issue Published: 1 December 1961 PDF downloadLoading ...