tbuckley/cabot-search huggingface dataset:
A CASE OF “GRANULOSIS RUBRA NASI” (JADASSOHN)
Authors: J. M. H. MACLEOD
Journal: British Journal of Dermatology (1903)

Journal Article A CASE OF “GRANULOSIS RUBRA NASI” (JADASSOHN) Get access J. M. H. MACLEOD, M.D., M.R.C.P. J. M. H. MACLEOD, M.D., M.R.C.P. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 15, Issue 6, 1 June 1903, Pages 197–206, https://doi.org/10.1111/j.1365-2133.1903.tb16501.x Published: 01 June 1903
Recovery from lung injury in survivors of acute respiratory distress syndrome: difference between pulmonary and extrapulmonary subtypes
Authors: Sun Jong Kim, Bum Jin Oh, Jin Sung Lee, Chae-Man Lim, Tae Sun Shim, Sang Do Lee, Woo Sung Kim, Dong Soon Kim, Won Dong Kim, Younsuck Koh
Journal: Intensive Care Medicine (2004)
Metabolic syndrome may be associated with increased arterial stiffness even in the absence of hypertension: A study in 84 cases and 82 controls
Authors: Pauliina Kangas, Antti J. Tikkakoski, Anna M. Tahvanainen, Miia H. Leskinen, Jani M. Viitala, Mika Kähönen, Tiit Kööbi, Onni J. Niemelä, Jukka T. Mustonen, Ilkka H. Pörsti
Journal: Metabolism (2013)
The Relation of Alcoholic Myopathy to Cardiomyopathy
Authors: Joaquim Fernandez-Sola
Journal: Annals of Internal Medicine (1994)

Objective: To evaluate the relation between skeletal muscle disease (myopathy) and degenerative changes in cardiac muscle (cardiomyopathy) in patients with chronic alcoholism. Design: A cross-sectional study. Setting: University medical center. Participants: Group A included 24 patients with chronic alcoholism who had dilated cardiomyopathy; group B, 24 patients with chronic alcoholism who had normal cardiac function; group C, 12 patients with dilated cardiomyopathy because of coronary heart disease; group D, 12 patients with idiopathic dilated cardiomyopathy; group E, 24 normal participants; and group F, 5 young men who died suddenly in traffic accidents. Measurements: Clinical assessment of muscle strength, echocardiography, radionuclide cardiac angiography (groups A to E), muscle biopsy (groups A, B, E), endomyocardial biopsy of the left ventricle (group A), and examination of postmortem specimens of the left ventricle (group F). Results: Alcoholic patients with cardiomyopathy had less muscle strength than did alcoholic patients with normal cardiac function, patients with idiopathic dilated cardiomyopathy, and patients with coronary heart disease (all P < 0.01). Among alcoholic patients with cardiomyopathy, 20 of 24 (83%) had histologic findings of skeletal myopathy compared with 1 of 24 (4%) alcoholic patients with normal cardiac function (P < 0.001). Interstitial fibrosis occurred in all cardiac biopsy specimens, hypertrophy of the myocytes occurred in 95%, and myocytolysis occurred in 83%. Those patients with more severe cellular hypertrophy and interstitial fibrosis of the myocardium had a greater decrease in deltoid muscle strength and had worse histologic myopathy. Conclusions: Diseases of skeletal and cardiac muscle in patients with chronic alcoholism are clinically and histologically related. The presence of muscle weakness in an alcoholic person suggests the likelihood of an accompanying cardiomyopathic abnormality.
Outcome of the treatment for sarcoidosis.
Authors: G W Hunninghake, S Gilbert, R Pueringer, C Dayton, C Floerchinger, R Helmers, R Merchant, J Wilson, J Galvin, D Schwartz
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

The clinical characteristics and pathology of sarcoidosis are well defined; however, the optimal therapy for this disorder remains unclear. Although patients respond, acutely, to corticosteroid therapy, it is not clear that these agents ultimately alter the natural history of this disease. These observations and that corticosteroids have significant side effects suggest that only patients who will clearly benefit from corticosteroid therapy should be treated. In a prospective study of patients' with sarcoidosis (n = 98), we limited our use of corticosteroids to those patients who had objective evidence of recent deterioration in lung function or serious extrapulmonary disease. All patients with sarcoidosis fulfilling these criteria were treated with corticosteroids. Patients were tapered off corticosteroids after they were treated for 1 yr. Of the 98 study subjects, 91 had not received therapy for the disease and 7 were on therapy before entry into the study. Of the 91 previously untreated patients, 55 were observed without therapy and 36 were treated with corticosteroids. Of those who were observed off therapy, only eight deteriorated. Of these latter patients, six responded and stabilized with the administration of corticosteroids for treatment of the underlying disease, to antibiotics for an associated bronchiectasis, or to diuretics for treatment for congestive heart failure; two were lost to follow-up. None of these six patients deteriorated while receiving corticosteroids. Of the 36 patients who deteriorated and were treated with corticosteroids, 20 remained stable and 16 improved clinically. Of the 37 patients who were eventually tapered off corticosteroids, five deteriorated and required reinitiation of corticosteroid therapy.(ABSTRACT TRUNCATED AT 250 WORDS)
The Long Lasting Lesion of Acute Methotrexate-Induced Encephalopathy Detected by Diffusion-Weighted MRI
Authors: M. Nakagawa, K. Miura, M. Kusuda, H. Takahashi, H. Kodaira, M. Yagi, D. Kurita, N. Iriyama, Y. Hatta, J. Takeuchi
Journal: Annals of Oncology (2013)
Immunohistochemical localization of apolipoprotein E in human glial neoplasms.
Authors: M Murakami, Y Ushio, Y Morino, T Ohta, Y Matsukado
Journal: Journal of Clinical Investigation (1988)

Immunocytochemical analyses revealed the presence and distribution of apolipoprotein E (apo E) in normal human brain tissue as well as in 77 human intracranial neoplasms. In normal brain tissues, the perikarya of astrocytes exhibited a strong positive reaction, whereas the Bergmann glia were stained to a moderate degree. However, no immunoreactivity was observed with neurons, oligodendrocytes, ependymal cells, and choroidal epithelium. Among the intracranial neoplasms, oligodendroglioma, choroid plexus papilloma, hemangioblastoma, primary malignant lymphoma, neurinoma, meningioma, pituitary adenoma, and craniopharyngioma were all negative. Immunoreactivity in the peripheral neuroblastoma was nil. However, the perikarya of astrocytomas and glioblastomas showed a positive reaction. Analyses on the degree of anaplasia and the amount of apo-E as an intensity of immunostaining showed a negative correlation. The astrocytic elements were stained in mixed oligoastrocytomas and medulloblastomas with glial differentiation. A few cases of ependymomas showed weak perikaryal immunostaining. Western blot analyses with anti-apo E antibody of a freshly prepared surgical specimen with astrocytomas revealed a single band with a molecular weight of approximately 37,000. The well differentiated cultured human astrocytoma cells secreted apo E into the medium. These lines of evidence suggest that apo E may serve as a potential marker specific for astrocytomas and glioblastomas, as well as an indicator of astrocytic tumor cell differentiation. The apo E localization in human brain tumors could be clinically relevant and diagnostically useful.
Classification of segmental vitiligo on the trunk
Authors: N. Geel, S. Bosma, B. Boone, R. Speeckaert
Journal: British Journal of Dermatology (2013)

Journal Article Classification of segmental vitiligo on the trunk Get access N. van Geel, N. van Geel Department of Dermatology Ghent University Hospital De Pintelaan 185 9000 Ghent Belgium Correspondence Nanja van Geel. E‐mail: nanja.vangeel@ugent.be Search for other works by this author on: Oxford Academic Google Scholar S. Bosma, S. Bosma Department of Dermatology Ghent University Hospital De Pintelaan 185 9000 Ghent Belgium Search for other works by this author on: Oxford Academic Google Scholar B. Boone, B. Boone Department of Dermatology Ghent University Hospital De Pintelaan 185 9000 Ghent Belgium Search for other works by this author on: Oxford Academic Google Scholar R. Speeckaert R. Speeckaert Department of Dermatology Ghent University Hospital De Pintelaan 185 9000 Ghent Belgium Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 170, Issue 2, 1 February 2014, Pages 322–327, https://doi.org/10.1111/bjd.12652 Published: 01 February 2014
Effects of two types of dietary fibre on faecal steroid and lipid excretion.
Authors: R L Walters, I M Baird, P S Davies, M J Hill, B S Drasar, D A Southgate, J Green, B Morgan
Journal: BMJ (1975)

Fibre supplements from wheat bran and sugar cane residue (bagasse) were added to the normal diet of volunteers for 12-week periods in a controlled metabolic study. Stool weights and stool fat excretion increased on both dietary fibres. Bagasse increased the daily loss of acid steroids, but bran failed to affect bile acid excretion. Decreased transit time without alteration in faecal flora occurred with bagasse. The raised excretion of bile acids and fatty acids failed to lower the plasma cholesterol and triglycerides after 12 weeks. Thus different fibre sources with variable components have dissimilar metabolic effects.
Pharmacodynamics of PEG-IFN α differentiate HIV/HCV coinfected sustained virological responders from nonresponders
Authors: Andrew H. Talal, Ruy M. Ribeiro, Kimberly A. Powers, Michael Grace, Constance Cullen, Musaddeq Hussain, Marianthi Markatou, Alan S. Perelson
Journal: Hepatology (2006)

Pegylated interferon (PEG-IFN) has become standard therapy for hepatitis C virus (HCV) infection. We evaluated whether PEG-IFN pharmacodynamics and pharmacokinetics account for differences in treatment outcome and whether these parameters might be predictors of therapeutic outcome. Twenty-four IFN-naïve, HCV/human immunodeficiency virus–coinfected patients received PEG-IFN α-2b (1.5 μg/kg) once weekly plus daily ribavirin (1,000 or 1,200 mg) for up to 48 weeks. HCV RNA and PEG-IFN α concentrations were obtained from samples collected frequently after the first 3 PEG-IFN doses. We modeled HCV kinetics incorporating pharmacokinetic and pharmacodynamic parameters. Although PEG-IFN concentrations and pharmacokinetic parameters were similar in sustained virological responders (SVRs) and nonresponders (NRs), the PEG-IFN α-2b concentration that decreases HCV production by 50% (EC50) was lower in SVRs compared with NRs (0.04 vs. 0.45 μg/L [ P = .014]). Additionally, the median therapeutic quotient ( i.e. , the ratio between average PEG-IFN concentration and EC50[C̄/EC50]), and the PEG-IFN concentration at day 7 divided by EC50 (C(7)/EC50) were significantly increased in SVRs compared with NRs after the first (10.1 vs. 1.0 [ P = .012], 2.8 vs. 0.3 [ P = .007], respectively) and second (14.0 vs. 1.1 [ P = .016], 5.4 vs. 0.4 [ P = .02], respectively) PEG-IFN doses. All 3 parameters may be used to identify NRs. In conclusion , PEG-IFN concentrations and pharmacokinetic parameters do not differ between SVRs and NRs. In contrast, pharmacodynamic measurements—namely EC50, the therapeutic quotient, and C(7)/EC50—are different in coinfected SVRs and NRs. These parameters might be useful predictors of treatment outcome during the first month of therapy. (Hepatology 2006;43:943–953.)
Peptic Ulcers and Radiology
Authors: R. L. Mansi
Journal: BMJ (1947)

apparent slight hyperaesthesia proximal to the line of demarcation, which might be explained by the band of hyperaemia as described by Gelfand.Knee-jerks were indeterminate.Wassermann examina- tion and blood counts could not be performed.The urine was free of sugar and albumin.The patient refused operation and would not enter hospital, so his further progress is not known.Williams (1939), discussing the results of 894 post-mortem examinations in Uganda, found 86 cases showing syphilitic arterial disease and considers that this is common in East Africa.Coombs (1932) points out that lesions most commonly follow one, two, or more decades after infection.This would fit in with the age groups of beth Gelfand's and my cases, particularly when it is remembered that the African often acquires his syphilis relatively early in life.Prior to Gelfand's paper I had considered my case to be definitely one of syphilitic origin.Now the question requires reconsideration.It may be that the part played by syphilis is merely an initial damage to the artery (Gordon et al., 1942), on which further processes later briiig about an ischaemia sufficiently suddenly to cause gangrene.On the other hand in cases where gangrene has followed syphilis the onset has usually been much less, sudden than in these seven cases.Choussat (1938), for instance, describes a ese of bilateral dry gangrene of the feet, of slow onset, in a child of 10.Bilateral gangrenous areas on the arms of a white woman of 61, in which the lesion on the left preceded that on the right, is cited by Goodman (1939).Similar cases will be found in papers by Fusco and Kell (1943) and Leone Bloise (1936), though I havepersonally not yet been able to trace them.When the high rate of syphilis in certain native populations is taken into account, figures ranging from 23% (Kark and Le Riche, 1944) to 40% (Rauch and Saayman, 1938) being sub- stantiated by various authors, the fact that three out of these seven cases of bilateral gangrene of the feet had syphilis may not be of significance but merely a coincidental finding.-Iam, etc.,
The overseas doctors training scheme
Authors: R. C Gupta, S. Lingam
Journal: BMJ (1999)

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The overseas doctors training scheme (ODTS) was established in 1984 and the Overseas Doctors' Association was a major party in contributing to its conception. Overseas doctors are those who are not nationals of the European Economic Area (EEA) or do not hold a primary qualification obtained in the EEA. The scheme is run by the royal colleges, with support from the education department of the NHS Executive. We asked all the colleges in the United Kingdom about the scheme they administer, and the table shows the current position.

The scheme has had a mixed reception since its inception: some have viewed it as useless and a backdoor entry to postgraduate medical training, while others regard it as a success with many fine achievements. Initially, the scheme was by a dual sponsorship programme run by individual consultants. The dual sponsorship scheme allowed a senior colleague (first sponsor) from overseas to arrange a training post with a consultant in Britain. The UK consultant becomes the second sponsor. With this recommendation the trainee doctor gets registration and a first training post in Britain. The colleges administered the scheme but usually did not place doctors in posts.

Under the scheme each college assesses the applications of the overseas doctors who wish to come to Britain for further training. The doctors, who must still be abroad, apply directly to the relevant college. Most colleges have a waiting list. Doctors who have come to Britain for training or to sit the Professional and Linguistic Assessment Board (PLAB) test will usually not be allowed to enter the scheme. The same applies to doctors who have sat or have applied to sit the PLAB tests. On the recommendation of their referee (usually the consultant under whom they work) and on the basis of application and experience, doctors are …

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US scientists class dioxins as a "health concern"
Authors: J Roberts
Journal: BMJ (1994)

After years of study and debate, government scientists in the US have now said that dioxins, a class of chlorinated hydrocarbons, are “probable human carcinogens” that account for up to 0.1% of all cancers in the US.

In a 2000 page draft report made public earlier this month the Environmental Protection Agency said that dioxins represent a public health “concern,” although it refuted the view of some environmentalists, who called dioxins a public health “emergency.”

Dioxins first emerged in public during the Vietnam …
THE VISCERAL LESIONS OF PURPURA AND ALLIED CONDITIONS
Authors: W. Osler
Journal: BMJ (1914)

IN his well-known work on Cutaneous Diseases (1808) WVillan first reported the occurrence of visceral symptoms in a case of purpura of great severity, with vomiting, excruciating abdom-iinal pain, diarrlloea and bloody stools.In addition to purpura, there wvere " anasarcous swellings on the thiglhs and lhands," evidently angio-neurotic oedema, and on tlhe back of tlle liands two gangrenous slouglhs.It is particularly interesting that Willan should have thus noted the polymorphouLs character of the skin eruption.Olivier (d'Angers),t in 1827, gave a good account of the abdomina,l comiiplications of purpura; and Henoch,2 1874, atnd Couty,3 1876, described the cases more fully, and now the combination of purpura with abdominal pains is called after the late distinguished Berlin paediatrist.Since then there have beep, scores of communications;-I lhave myself reported long series of cases; 4and Pratt lhas given a good summary of our present knowledge in vol.iv of my System of Medicine.Tlle general literature of purpura to 1909 is given in thle first and second series of the Index Catalogue of the Sil)geon-General's Library.An excellent analysis of the recorded cases with abdominal symptoms to 1889 is given by v. Duscll and Hoche in the Henoch Festschrirft, B3erlin, 1890.. CHARACTER OF THE SKIN LESIONS.From the anatomical standpoint four lesions are met with in the cases -under consideration.All are exudative, in wlich the blood elemiients-either the red blood corpuscles alone, the serum alone, or both combinedpass out of the vessels.
Fatal Ostial Right Coronary Artery Coronary Stent Fracture and Perforation Induced by Mechanical Stress Between the Sternum and Dilated Aortic Root
Authors: Tomoya Hoshi, Akira Sato, Hidetaka Nishina, Yuki Kakefuda, Yuichi Noguchi, Kazutaka Aonuma
Journal: Circulation (2011)
Adolescence and Breakdown
Authors: A. H. Crisp
Journal: BMJ (1975)

patent ductus arteriosus showing left ven- tricular hypertrophy appears again on p. 46, this time said to be from a patient with valvar aortic stenosis, on p. 76 from a child with a postductal coarctation of the aorta, and yet again on p. 169 from an infant with endocardial fibroelastosis.The record stated in the caption on p. 13 to be from a patient with a classical ventricular septal defect purports later to be from a 6-year-old patient with a patent ductus arteriosus with combined ventricular hypertrophy, and finally to have been taken in a 1-year-old infant with type 2 truncus arteriosus.Likewise, the same E.C.G., each time with a slightly different caption, is used to illustrate chapters on pulmonary valvar stenosis, the tetralogy of Fallot, transposition of the great arteries, preductal coarctation, type 4 truncus arteriosus, and the Eisenmenger syndrome.
Analysis of left ventricular function from multiple gated acquisition cardiac blood pool imaging. Comparison to contrast angiography.
Authors: R D Burow, H W Strauss, R Singleton, M Pond, T Rehn, I K Bailey, L C Griffith, E Nickoloff, B Pitt
Journal: Circulation (1977)

Global ventricular function was evaluated by both multiple gated cardiac blood pool scans (MUGA) and contrast ventriculograms in a group of 17 patients with suspected coronary artery disease. The contrast ventriculograms were analyzed frame by frame to generate a volume versus time curve for each patient, while the tracer data were analyzed by two methods: 1) the standard method, in which the left ventricle is identified on the end-diastolic frame and the background corrected activity under the region of interest obtained from the entire cardiac cycle, and displayed as a time versus activity curve; and 2) by a semi-automatic method in which the computer applies a threshold detection program to define the ventricular borders, and activity in the chamber at each point in the cardiac cycle is defined after background correction. The tracer data in each patient were analyzed independently by four observers. The tracer data correlated with the contrast data on a point by point basis r = 0.87 for the standard method, and 0.93 for the semi-automatic technique. An F test of variance revealed the semi-automatic method superior to the standard approach (P less than 0.05).
The prevalence of epidermolysis bullosa in Scotland
Authors: H.M. HORN, G.C. PRIESTLEY, R.A.J. EADY, M.J. TIDMAN
Journal: British Journal of Dermatology (1997)

The prevalence of epidermolysis bullosa (EB) in Britain and most other countries is unknown. Patients suffering from the inherited forms of EB and living in Scotland have been traced. Two hundred and fifty-nine affected people from 76 families have been identified, of whom 211 were clinically assessed. One-third of these Scottish EB sufferers had never been seen by a dermatologist. In Lothian, where there appears to be a relatively high prevalence of EB, 75% of patients were unknown to their general practitioners. The point prevalence of all forms of EB at the outset of the study was 49.0 per million, comprising EB simplex 28.6 per million and dystrophic EB 20.4 per million. Extrapolation of accurate data available for the Lothians suggests that the point prevalence of all forms of EB in Scotland is in excess of these figures.
New insights into the definition and meaning of proarrhythmia during initiation of antiarrhythmic drug therapy from the cardiac arrhythmia suppression trial and its pilot study
Authors: D.George Wyse, Joel Morganroth, Robert Ledingham, Pablo Denes, Alfred Hallstrom, L.Brent Mitchell, Andrew E. Epstein, Raymond L. Woosley, Robert Capone
Journal: Journal of the American College of Cardiology (1994)
Determination of Cardiac Risk by Dipyridamole-Thallium Imaging before Peripheral Vascular Surgery
Authors: Charles A. Boucher, David C. Brewster, R. Clement Darling, Robert D. Okada, H. William Strauss, Gerald M. Pohost
Journal: New England Journal of Medicine (1985)

To evaluate the severity of coronary artery disease in patients with severe peripheral vascular disease requiring operation, we performed preoperative dipyridamole–thallium imaging in 54 stable patients with suspected coronary artery disease. Of the 54 patients, 48 had peripheral vascular surgery as scheduled without coronary angiography, of whom 8 (17 per cent) had postoperative cardiac ischemic events. The occurrence of these eight cardiac events could not have been predicted preoperatively by any clinical factors but did correlate with the presence of thallium redistribution. Eight of 16 patients with thallium redistribution had cardiac events, whereas there were no such events in 32 patients whose thallium scan either was normal or showed only persistent defects (P<0.0001). Six other patients also had thallium redistribution but underwent coronary angiography before vascular surgery. All had severe multivessel coronary artery disease, and four underwent coronary bypass surgery followed by uncomplicated peripheral vascular surgery. These data suggest that patients without thallium redistribution are at a low risk for postoperative ischemic events and may proceed to have vascular surgery. Patients with redistribution have a high incidence of postoperative ischemic events and should be considered for preoperative coronary angiography and myocardial revascularization in an effort to avoid postoperative myocardial ischemia and to improve survival. Dipyridamole–thallium imaging is superior to clinical assessment and is safer and less expensive than coronary angiography for the determination of cardiac risk. (N Engl J Med 1985; 312:389–94.)