tbuckley/cabot-search huggingface dataset:
Maxzide or Dyazide: A Cautionary Note
Authors: NORMAN M. KAPLAN
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 May 1985Maxzide or Dyazide: A Cautionary NoteNORMAN M. KAPLAN, M.D.NORMAN M. KAPLAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-5-717_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A massive campaign, including eight-page, heavy-paper advertisements in most medical journals, has been mounted for a new formulation of triamterene and hydrochlorothiazide, Maxzide (Lederle Laboratories, Wayne, New Jersey). The manufacturers have emphasized the improved, virtually 100% bioavailability of both ingredients in their formulation compared with that of the only other available formulation, Dyazide (SmithKline & French Co., Carolina, Puerto Rico). Dyazide has become the single largest-used diuretic product in the United States and in fact is the number one prescribed drug in volume, with 1983 sales of over $210 million.Dyazide has 25 mg of hydrochlorothiazide, of...References1. TANNENBAUMROSENFLANAGANCROSLEY PETA. The influence of dosage form on the activity of a diuretic agent. Clin Pharmacol Ther. 1968;9:598-604. CrossrefMedlineGoogle Scholar2. BLUMEWILLIAMSUPTONLINBENET CRREL. Bioequivalence study of a new tablet formulation of triamterene and hydrochlorothiazide. Am J Med. 1984;77:59-61. CrossrefMedlineGoogle Scholar3. BEERMANGROSCHINSKY-GRIND BM. Antihypertensive effect of various doses of hydrochlorothiazide and its relation to the plasma level of the drug. Eur J Clin Pharmacol. 1978;13:195-201. CrossrefMedlineGoogle Scholar4. The 1984 report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. Arch Intern Med. 1984;144:1045-57. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA Comparison of the Anti-Hypertensive Effectiveness of Two Triameterene/Hydrochlorothiazide Combinations: Maxzide Versus DyazideSubacute cutaneous lupus erythematosus—like drug eruption due to combination diuretic hydrochlorothiazide and triamterenePharmacokinetics of the thiazide diureticsThiazides and Thiazide-like Diuretics in HypertensionMARK C. HOUSTON, M.D. 1 May 1985Volume 102, Issue 5Page: 717-717KeywordsDiureticsDrugs Issue Published: 1 May 1985 PDF DownloadLoading ...
Widely Used Pesticides with Previously Unknown Endocrine Activity Revealed as <i>in Vitro</i> Antiandrogens
Authors: Frances Orton, Erika Rosivatz, Martin Scholze, Andreas Kortenkamp
Journal: Environmental Health Perspectives (2011)

BackgroundEvidence suggests that there is widespread decline in male reproductive health and that antiandrogenic pollutants may play a significant role. There is also a clear disparity between pesticide exposure and data on endocrine disruption, with most of the published literature focused on pesticides that are no longer registered for use in developed countries.ObjectiveWe used estimated human exposure data to select pesticides to test for antiandrogenic activity, focusing on highest use pesticides.MethodsWe used European databases to select 134 candidate pesticides based on highest exposure, followed by a filtering step according to known or predicted receptor-mediated antiandrogenic potency, based on a previously published quantitative structure–activity relationship (QSAR) model. In total, 37 pesticides were tested for in vitro androgen receptor (AR) antagonism. Of these, 14 were previously reported to be AR antagonists (“active”), 4 were predicted AR antagonists using the QSAR, 6 were predicted to not be AR antagonists (“inactive”), and 13 had unknown activity, which were “out of domain” and therefore could not be classified with the QSAR (“unknown”).ResultsAll 14 pesticides with previous evidence of AR antagonism were confirmed as antiandrogenic in our assay, and 9 previously untested pesticides were identified as antiandrogenic (dimethomorph, fenhexamid, quinoxyfen, cyprodinil, λ-cyhalothrin, pyrimethanil, fludioxonil, azinphos-methyl, pirimiphos-methyl). In addition, we classified 7 compounds as androgenic.ConclusionsDue to estimated antiandrogenic potency, current use, estimated exposure, and lack of previous data, we strongly recommend that dimethomorph, fludioxonil, fenhexamid, imazalil, ortho-phenylphenol, and pirimiphos-methyl be tested for antiandrogenic effects in vivo. The lack of human biomonitoring data for environmentally relevant pesticides presents a barrier to current risk assessment of pesticides on humans.
John Collins Warren (1778-1856): An American surgeon in London
Authors: D. K. C. Cooper
Journal: BMJ (2012)

<h3>Abstract</h3> <h3>Motivation</h3> Circadian rhythms are approximately 24 hour endogenous cycles that control many biological functions. To identify these rhythms, biological samples are taken over circadian time and analyzed using a single omics type, such as transcriptomics or proteomics. By comparing data from these single omics approaches, it has been shown that transcriptional rhythms are not necessarily conserved at the protein level, implying extensive circadian post-transcriptional regulation. However, as proteomics methods are known to be noisier than transcriptomic methods, this suggests that previously identified arrhythmic proteins with rhythmic transcripts could have been missed due to noise and may not be due to post-transcriptional regulation. <h3>Results</h3> To determine if one can use information from less-noisy transcriptomic data to inform rhythms in more-noisy proteomic data, and thus more accurately identify rhythms in the proteome, we have created the MOSAIC (Multi-Omics Selection with Amplitude Independent Criteria) application. MOSAIC combines model selection and joint modeling of multiple omics types to recover significant circadian and non-circadian trends. Using both synthetic data and proteomic data from <i>Neurospora crassa</i>, we showed that MOSAIC accurately recovers circadian rhythms at higher rates in not only the proteome but the transcriptome as well, outperforming existing methods for rhythm identification. In addition, by quantifying non-circadian trends in addition to circadian trends in data, our methodology allowed for the recognition of the diversity of circadian regulation as compared to non-circadian regulation. <h3>Availability</h3> MOSAIC’s full interface is available at https://github.com/delosh653/MOSAIC. <h3>Contact</h3> hurlej2@rpi.edu <h3>Supplementary information</h3> Supplementary data are available.at <i>Bioinformatics</i> online.
Specific Oral Tolerance Induction With A Weekly Updosing Schedule In Children With Ige Mediated Cow's Milk Allergy
Authors: G.B. Pajno, L. Caminiti, S. Barberi, D. Vita, C.E. Baena-Cagnani, G. Barberio, P. Ruggeri, G. Passalacqua
Journal: Journal of Allergy and Clinical Immunology (2009)
Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis and Small Aortic Annulus
Authors: Dimitri Kalavrouziotis, Josep Rodés-Cabau, Rodrigo Bagur, Daniel Doyle, Robert De Larochellière, Philippe Pibarot, Eric Dumont
Journal: Journal of the American College of Cardiology (2011)
Association of atopic dermatitis to the beta subunit of the high affinity immunoglobulin E receptor
Authors: None Cox, None Moffatt, None Faux, None Walley, None Coleman, None Trembath, None Cookson, None Harper
Journal: British Journal of Dermatology (1998)

IgE dysregulation is a major pathogenic feature of atopic dermatitis and other IgE-mediated allergic diseases such as asthma and rhinitis. Allergen complexed to IgE binds to the high affinity receptor for IgE (Fc epsilon RI) on the surface of epidermal Langerhans cells, mast cells and basophils, triggering the release of inflammatory mediators. The beta subunit of Fc epsilon RI has been localized to human chromosome 11q12-13, and variants within this gene have been shown to associate with asthma and measures of atopy. We have tested several polymorphisms within Fc epsilon RI-beta for association to atopic dermatitis in a panel of 60 families (panel A), recruited through a proband with atopic dermatitis. The findings were tested in a second panel of families (panel B). Significant sharing of maternal alleles was seen for atopic dermatitis and allele 2 of RsaI intron 2 (RsaIvin2*2) (P = 0.0022) and allele 1 of RsaI exon 7 (RsaIvex7*1) (P = 0.0036) Fc epsilon RI-beta gene polymorphisms. These findings were replicated in Panel B, confirming the association of Fc epsilon RI-beta RsaI polymorphisms with atopic dermatitis. The combined significance of the association of atopic dermatitis to RsaI polymorphisms was P = 0.0002 (RsaIvin2*2) and P = 0.00034 (RsaIvex7*1). The polymorphisms also showed association with asthma: P = 0.0068 (RsaIvin2*2) and P = 0.018 (RsaIvex7*1). Polymorphisms within the Fc epsilon RI-beta gene are strongly associated with atopic dermatitis.
Comprehensive Adolescent Health Care
Authors: F. Bruder Stapleton
Journal: Annals of Internal Medicine (1998)

Medical Writings1 July 1998Comprehensive Adolescent Health CareF. Bruder Stapleton, MDF. Bruder Stapleton, MDUniversity of Washington School of Medicine, Seattle, Washington.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-1-199807010-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Comprehensive Adolescent Health Care; 2nd edition. Friedman SB, Fisher M, Schonberg SK, Alderman EM. 1349 pages. St. Louis, MO: Mosby-Year Book; 1998. $150.00. ISBN 0815133863. Order phone 800-426-4545.Field of medicine: Adolescent medicine.Format: Hardcover book.Audience: General pediatricians and internists, family physicians, gynecologists, specialists in adolescent medicine, and mental health professionals treating adolescents.Purpose: To enable health care providers to recognize and manage the medical, surgical, psychosocial, and gynecologic conditions commonly encountered in adolescents.Content: This comprehensive text discusses the principles of adolescent medicine as well as the medical, surgical, gynecologic, and psychological disorders that are common in adolescent ... Author, Article, and Disclosure InformationAuthors: F. Bruder Stapleton, MDAffiliations: University of Washington School of Medicine, Seattle, Washington. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1998Volume 129, Issue 1 Page: 80 Keywords Adolescent medicine Adolescents Health care Nephrology Pregnancy Psychiatry and mental health Skin diseases Sports and exercise medicine Substance abuse Transplantation ePublished: 15 August 2000 Issue Published: 1 July 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
ASSOCIATION OF HIGH-RISK MORPHOLOGICAL CHARACTERISTICS BY OPTICAL COHERENCE TOMOGRAPHY WITH COMPLEX ANGIOGRAPHIC MORPHOLOGY IN CULPRIT LESIONS OF PATIENTS WITH ACUTE CORONARY SYNDROMES
Authors: Antonios Karanasos, Konstantinos Toutouzas, Andreas Synetos, Eleftherios Tsiamis, Dimitrios Tousoulis, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2011)
Patterns of Use of Perioperative Angiotensin-Converting Enzyme Inhibitors in Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass
Authors: Benjamin Drenger, Manuel L. Fontes, Yinghui Miao, Joseph P. Mathew, Yaacov Gozal, Solomon Aronson, Cynthia Dietzel, Dennis T. Mangano
Journal: Circulation (2012)

Despite proven benefit in ambulatory patients with ischemic heart disease, the pattern of use of angiotensin-converting enzyme inhibitors (ACEIs) in coronary artery bypass graft surgery has been erratic and controversial.This is a prospective observational study of 4224 patients undergoing coronary artery bypass graft surgery. The cohort included 1838 patients receiving ACEI therapy before surgery and 2386 (56.5%) without ACEI exposure. Postoperatively, the pattern of ACEI use yielded 4 groups: continuation, 915 (21.7%); withdrawal, 923 (21.8%); addition, 343 (8.1%); and no ACEI, 2043 (48.4%). Continuous treatment with ACEI versus no ACEI was associated with substantive reductions of risk of nonfatal events (adjusted odds ratio for the composite outcome, 0.69; 95% confidence interval, 0.52-0.91; P=0.009) and a cardiovascular event (odds ratio, 0.64; 95% confidence interval, 0.46-0.88; P=0.006). Addition of ACEI de novo postoperatively compared with no ACEI therapy was also associated with a significant reduction of risk of composite outcome (odds ratio, 0.56; 95% confidence interval, 0.38-0.84; P=0.004) and a cardiovascular event (odds ratio, 0.63; 95% confidence interval, 0.40-0.97; P=0.04). On the other hand, continuous treatment of ACEI versus withdrawal of ACEI was associated with decreased risk of the composite outcome (odds ratio, 0.50; 95% confidence interval, 0.38-0.66; P<0.001), as well as a decrease in cardiac and renal events (P<0.001 and P=0.005, respectively). No differences in in-hospital mortality and cerebral events were noted.Our study suggests that withdrawal of ACEI treatment after coronary artery bypass graft surgery is associated with nonfatal in-hospital ischemic events. Furthermore, continuation of ACEI or de novo ACEI therapy early after cardiac surgery is associated with improved in-hospital outcomes.
Act now to fight chronic procrastination disorder
Authors: R. Moynihan
Journal: BMJ (2013)

Procrastination awareness week will happen next week—or the week after that



For those who like to keep up with the latest developments in medicine, a new disease was launched earlier this month at the University of Melbourne’s 2013 Festival of Ideas. Close to 200 scientists, clinicians, citizens, and public relations experts spent almost half an hour creating the new condition, chronic procrastination disorder, for which the inaugural global disease awareness week will take place next week. Or the week after.

Among the stellar group of scientists who helped design the new disease was the high profile epidemiologist Fiona Stanley, who spent several moments developing and validating a severity index, highlighting the condition’s wide spectrum of symptoms. At the mild end are people who are unbearably slow to place orders at restaurants; at the severe end are those facing jail sentences for persistent failure to file tax returns. 

Also present was the psychiatrist Jon Jureidini, who helped set the diagnostic thresholds that draw the line between common indecision and debilitating procrastination. Answering questions from journalists at the mock launch of the disease, Jureidini confirmed that he was a company funded “key opinion …
Matrix Metalloproteinase-9 Is Necessary for the Regulation of Smooth Muscle Cell Replication and Migration After Arterial Injury
Authors: Aesim Cho, Michael A. Reidy
Journal: Circulation Research (2002)

Matrix metalloproteinases (MMPs) and, in particular, MMP-9 are important for smooth muscle cell (SMC) migration into the intima. In this study, we sought to determine whether MMP-9 is critical for SMC migration and for the formation of a neointima by using mice in which the gene was deleted (MMP-9 −/− mice). A denuding injury to the arteries of wild-type mice promoted the migration of medial SMCs into the neointima at 6 days, and a large neointimal lesion was observed after 28 days. In wild-type arteries, medial SMC replication was ≈8% at day 4, 6% at day 6, and 4% at day 8 and had further decreased to 1% at day 14. Intimal cell replication was 65% at 8 days and had decreased to ≈10% at 14 days after injury. In MMP-9 −/− arteries, SMC replication was significantly lower at day 8. In addition, SMC migration and arterial lesion growth were significantly impaired in MMP-9 −/− arteries. SMCs, isolated from MMP-9 −/− mouse arteries, showed an impairment of migration and replication in vitro. Thus, our present data indicate that MMP-9 is critical for the development of arterial lesions by regulating both SMC migration and proliferation.
BMA's view on generic substitution
Authors: J. Richards
Journal: BMJ (1992)

provincial clinic seeing around 4500 new cases a year.In two weeks 116 calls were made for results and 65 for advice (roughly 9000 annually).Most of these calls were dealt with by clerical and nursing staff, but to do so adequately they require experience and training.If telephone calls are to be used more their use should be included in routine statistics and the demand they make planned for.
Ebola in Greece?
Authors: B. Dixon
Journal: BMJ (1996)

One of our most deadly and dramatically publicised “new” infections may really be as old as the hills. The possibility arises with speculation that the great plague which hit Athens during the Spartan siege from 430 to 427 BC was not an epidemic of smallpox, typhus, typhoid fever, bubonic plague, cerebrospinal fever, or any of the other many diseases that historians have suggested, but was caused by Ebola virus.

The idea comes from epidemiologist Patrick Olson, of the Naval Medical Center in San Diego, who has considered the matter not only with fellow scientists but also with a classicist colleague.

“The most disastrous and fateful epidemic of recorded ancient …
Complete amino acid sequences of variable regions of two human IgM rheumatoid factors, BOR and KAS of the Wa idiotypic family, reveal restricted use of heavy and light chain variable and joining region gene segments.
Authors: M M Newkirk, R A Mageed, R Jefferis, P P Chen, J D Capra
Journal: The Journal of Experimental Medicine (1987)

Evidence derived from the complete amino acid sequences of the variable regions of both the heavy and light chains of two members (BOR and KAS) of the Wa idiotypic family of human rheumatoid factors suggests that not only are the light chains of these molecules derived from possibly one variable region gene segment, but the heavy chain variable regions are all derived from the VHI subgroup of human V region genes. These molecules exhibit a surprising conservation in the size of D region, and all use the JH4 gene element. This restriction in use of VL, VH, D, and JH suggests all of these elements may play a crucial role in either antigen binding and/or expression of the crossreactive idiotype.
Clinical examination for developmental dysplasia of the hip in neonates: how to stay out of trouble
Authors: D. M. Eastwood, A. de Gheldere
Journal: BMJ (2010)

A two week old baby girl was referred to the orthopaedic department by her local consultant in neonatology because of concerns regarding her left hip.

The patient was born at 39 weeks by spontaneous vertex delivery and had a birth weight of 2.82 kg. Although the fetus had laid abnormally during pregnancy, it had been in a cephalic presentation for most of the last trimester. No family history of hip problems was noted.

On examination of the lower limbs, the infant’s legs were of equal length and the skin creases were symmetrical. Both hips abducted less than 60° and a “click”/“clunk” was felt on movement of the left hip. Neurological examination was normal and the neonate had no clinical signs of spinal dysraphism.



### 1 What is the likely diagnosis?

#### Short answer

The clinical signs are highly suspicious of bilateral hip dislocation (developmental dysplasia of the hip). The left hip “click”/“clunk” suggests a positive Ortolani test, in which case the hip would be reducible. The right hip, by contrast, was irreducible and much more concerning.

#### Long answer

The incidence of developmental dysplasia of the hip in the United Kingdom is 1.5 cases per 1000 people1; in 20% of cases (0.3 per 1000 people), both hips are affected. Bilateral dysplasia is rare and can pose a potentially perilous situation for the unwary examiner: the examination findings typical of unilateral hip dislocation—unequal leg length and an asymmetric appearance of the thigh skin folds—are absent. In bilateral hip dislocation, the skin folds are symmetrical and the Galeazzi test is negative (box).

#### Tests for developmental dysplasia of the hip

Galeazzi test: Child lies supine on an examination table with the hips fully flexed, the feet flat on the table, and the ankles touching the buttocks. The test is positive when the …
From mouth to mouth and hand to hand: On language evolution
Authors: Uwe Jürgens
Journal: Behavioral and Brain Sciences (2003)

This commentary points to the lack of sound data supporting Corballis's thesis that there is a general left-hemisphere dominance for nonverbal vocal production in mammals. I also point out that area F5 in the rhesus monkey, which Corballis considers as homologous to Broca's area, contains not only visual “mirror” neurons but also auditory “mirror” neurons. This weakens Corballis's thesis that language developed exclusively at the gestural level.
Abstract 1386: A novel approach to develop anti-VEGFR2/KDR therapeutics: characterizing and targeting the G-quadruplex
Authors: Vanessa C. Gaerig, Jessica S. Fortin, Robert V. Brown, Tracy A. Brooks
Journal: Cancer Research (2010)

Abstract The anti-angiogenic approach is traditionally considered for solid malignancies, but increasing evidence has also highlighted its involvement in the progression of hematological oncologies. Angiogenesis, including expression of key proteins, is aberrant in blood cancers such as leukemias, lymphomas, and myelomas, in addition to many solid malignancies, including pancreatic cancer. The most critical mediator of oncogenic angiogenesis is vascular endothelial growth factor (VEGF), which is recognized by two high-affinity receptor tyrosine kinases, VEGFR1 and VEGFR2 (KDR gene). VEGFR2 is necessary for the survival, growth, and differentiation of endothelial cells as its downstream effects include activation of the MAPK and the PI3K pathways, and its upregulation is observed under conditions of pathological angiogenesis. While VEGF/VEGFR2 signaling is known to act in a paracrine manner on endothelial cells, autocrine signaling has been observed in both malignant cells and hematopoietic stem cells. For endothelial and hematological malignancies, both autocrine and paracrine pathways can be targeted with anti-VEGFR2 therapies, potentially doubling the clinical efficacy. Intriguingly, the promoter region of KDR contains a GC-rich region of DNA within its the core promoter located −120 to −31 basepairs (bp) upstream of the transcriptional start site (TSS), putatively able to form several G-quadruplexes. These are unique DNA secondary structures that often serve as transcriptional silencer elements. In the present study, G-quadruplex formation has been isolated −80 to −38 bp upstream of the TSS, which contains five strings of guanines that form a mixed parallel/anti-parallel G-quadruplex, as determined by circular dichroism. The cleavage pattern of DMS footprinting and the major stop product of the polymerase stop assay confirmed that the dominant isoform is a parallel G-quadruplex occurring within the four 3’ runs of guanines. Mutant studies were performed to further determine guanines integral to G-quadruplex formation. An electrophoretic mobility shift assay was used to confirm the formation of a biologically relevant intramolecular structure. High-throughput screening identified a novel KDR-interactive agent, NSC643735, which thermally stabilized the G-quadruplex. This compound is currently being tested in vitro, and has high potential to transcriptionally downregulate KDR mRNA and, subsequently, VEGFR2 protein. These data characterizing the formation of a unique secondary structure in an important oncogene are promising to develop novel and specific anti-KDR therapy for the treatment of hematological and solid malignancies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1386.