tbuckley/cabot-search huggingface dataset:
Electrocardiographic Features of Arrhythmogenic Right Ventricular Dysplasia
Authors: Rahul Jain, Darshan Dalal, Amy Daly, Crystal Tichnell, Cynthia James, Ariana Evenson, Rohit Jain, Theodore Abraham, Boon Yew Tan, Hari Tandri, Stuart D. Russell, Daniel Judge, Hugh Calkins
Journal: Circulation (2009)

The purpose of this study was to reevaluate the ECG features of arrhythmogenic right ventricular dysplasia (ARVD). The second objective was to evaluate the sensitivity and specificity of the standard and newly proposed diagnostic ECG markers in the presence of a right bundle-branch block (RBBB).One hundred patients with ARVD (57 men; aged 39+/-15 years) and 57 controls (21 men; aged 40+/-17 years) were included. Among the 100 patients with ARVD, a complete RBBB was present in 17 patients, and 15 patients had an incomplete RBBB. T-wave inversion through V(3) demonstrated optimal sensitivity and specificity in both ARVD patients without a complete RBBB or incomplete RBBB (71% [95% confidence interval, 58% to 81%] and 96% [95% confidence interval, 81% to 100%], respectively) and in ARVD patients with incomplete RBBB (73% [95% confidence interval, 45% to 92%] and 95% [95% confidence interval, 77% to 100%], respectively). Between ARVD patients and controls with a complete RBBB, the only 2 parameters that differed were the prevalence of T-wave inversion through V(4) (59% versus 12%, respectively; P<0.05) and an r'/s ratio in V(1) <1 (88% versus 14%, respectively; P<0.005). In ARVD patients with complete RBBB, the most sensitive and specific parameter was an r'/s ratio <1.We evaluated comprehensively the diagnostic value of ECG markers for ARVD. On the basis of the findings, we propose an algorithm, with examination of QRS morphology being the first step, for ECG evaluation of ARVD patients. Definite criteria are then applied on the basis of the presence of no RBBB, incomplete RBBB, and complete RBBB to obtain the best diagnostic utility of the ECG.
Abstract 5438: The <i>ex vivo</i> approach of testing drug activity with clinical leukemia specimens
Authors: Jiwei Lu, Dongqing Zhang, Li Chen, Licui Wang, Shi Chen, Lili Shu, Taiping Chen
Journal: Cancer Research (2011)

Abstract There is an urgent need to establish better preclinical evaluation platforms for anticancer drug development. To understand the therapeutic potential for leukemia patients, we establish an ex vivo platform for anti-leukemia compounds on freshly isolated leukemia blast cells. The primary leukemia cells were isolated from patients’ fresh bone marrow samples with Human Mononuclear Isolation Medium HISTOPAQUE-1077(Sigma-Aldrich) and subjected to different concentrations of testing anti-leukemia compounds. Then, the treated specimens were detected with annexin V/7-AAD and PI/FACS assays by flow cytometry to measure apoptosis and cell cycle. We have examined 54 cases (7 of ALL, 26 of AML, 21 of undetermined) of leukemia patients’ fresh bone marrow samples with 5 compounds. The leukemia blast cells displayed a dose-dependent drug reactivity which could be estimated through IC50. Combined with the patients’ clinical information, we found that patients showed distinct sensitivity to anti-leukemia compounds, which may guide further research on drug discovery. Therefore, these data provide a foundation for the preclinical investigation of anti-leukemia compounds. The ex vivo system constitutes a more sensitive and quantitative platform for the therapeutic potential of anti-leukemia compounds. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5438. doi:10.1158/1538-7445.AM2011-5438
The CML-related oncoprotein BCR/ABL induces expression of histidine decarboxylase (HDC) and the synthesis of histamine in leukemic cells
Authors: Karl J. Aichberger, Matthias Mayerhofer, Anja Vales, Maria-Theresa Krauth, Karoline V. Gleixner, Martin Bilban, Harald Esterbauer, Karoline Sonneck, Stefan Florian, Sophia Derdak, Winfried F. Pickl, Hermine Agis, Andras Falus, Christian Sillaber, Peter Valent
Journal: Blood (2006)
Dialysis dementia: recovery after transplantation.
Authors: P Sullivan, D J Murnaghan, N Callaghan
Journal: BMJ (1977)

<h3>ABSTRACT</h3> Epigenetic data obtained from whole zebrafish embryos or larvae may mask or dilute organ-specific information. Fluorescence activated cell sorting can diverge cells from their native state, and cryosections often yield insufficient material for molecular analysis. Here, we present a reproducible method for larval intestinal isolation at 5, 7, and 9 days post-fertilization, using the intestine-specific transgene <i>tgBAC(cldn15la:GFP)</i>. With tweezers, the intestine can be pulled out of the abdomen in one smooth motion. Upon removal of adhering tissues, intestines can be directly used for analyses. Each dissection takes 3-6 minutes per fish. We demonstrate that 10 and 25 dissected intestines yield enough material for RNA-sequencing and ChIP-sequencing, respectively. This method results in high quality, live material, suitable for many downstream applications. <h3>METHOD SUMMARY</h3> We present a reproducible method for zebrafish larval intestinal isolation which results in high quality, live material. With tweezers, the intestine can be pulled out of the abdomen and after removal of adhering tissues, intestines can be directly used for analyses. We demonstrate that 10 and 25 dissected intestines yield enough material for RNA-sequencing and ChIP-sequencing, respectively.
DIAGNOSIS AND SYMPTOMS OF APPENDICITIS.
Authors: J. H. CARSTENS
Journal: JAMA (1897)

The diagnosis of appendicitis is now generally made without difficulty by the general practitioners. Still sometimes a mistake is made and the diagnosis not easy on account of obscure symptoms. The first symptom is pain and this varies in location. It is seldom in the region of the appendix at first, but most frequently is referred to the umbilicus. In a smaller number of cases, the pain is first located in the region of the stomach, especially in cases accompanied by vomiting; and in a very small proportion of cases only, is it located by the patient in the region of the appendix. The pain is generally spasmodic, colicky, hence the expression, "appendicular colic." Sometimes, however, the pain is not so sharp and acute, but is dull and constant. Remember, I am referring to the very first symptoms. In the acute fulminating kind, when the appendix is ruptured and diffuse
Genetic Clues to the Cause of Primary Pulmonary Hypertension
Authors: Joseph Loscalzo
Journal: New England Journal of Medicine (2001)

Primary pulmonary hypertension is a devastating disease that is invariably fatal without definitive therapy. The disorder is more appropriately called a syndrome, since it is characterized by a set of clinical and pathophysiological features common to a variety of underlying causes. The proposed causes of primary pulmonary hypertension range widely, from environmental (e.g., hypoxia) to autoimmune (e.g., systemic lupus erythematosus) to drug related (e.g., dexfenfluramine use). Although genetic determinants no doubt indirectly influence the propensity for primary pulmonary hypertension to develop in response to these factors, a heritable form of primary pulmonary hypertension, familial primary pulmonary hypertension, has also been . . .
Details of federally funded studies should be available on web, US commission says
Authors: J. H. Tanne
Journal: BMJ (2011)

People who take part in federally funded research studies need better protection, and trials should be more closely tracked, says a report from a US commission.

The Presidential Commission for the Study of Bioethical Issues said that the public should have website access to information about all research conducted by federal agencies that involves human participants. The federal government should also consider setting up a national system of compensation for people injured in trials. 

Amy Gutmann, president of the University of Pennsylvania and chairwoman of the commission, acknowledged that “current rules and regulations provide substantial and adequate safeguards to mitigate risk and to protect human subjects against unethical treatment.” However, …
Occupational asthma in a pharmaceutical worker exposed to hydralazine.
Authors: B Perrin, J L Malo, A Cartier, S Evans, J Dolovich
Journal: Thorax (1990)

A pharmaceutical worker developed asthma when exposed to hydralazine, an antihypertensive drug. The diagnosis of occupational asthma was supported by specific inhalation challenges, which produced a late asthmatic reaction and an increase in bronchial responsiveness. No evidence of an IgE or an IgG dependent mechanism could be found.
Angioplasty for renal artery stenosis
Authors: R. Ames
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vinegar and visual inspection used to detect cervical cancer
Authors: Z. Kmietowicz
Journal: BMJ (1999)

The technique of wiping the cervix with vinegar (acetic acid) and then inspecting it visually can be used to detect most cases of cervical cancer and precancer, according to a study carried out in Zimbabwe (Lancet 1999;353:869-73).

The technique could be used to screen women for cervical cancer in developing countries, where cancer of the cervix remains the leading cause of death from cancer among women. An estimated 300000 women …
Screening for Thyroid Disease
Authors: Mark Helfand
Journal: Annals of Internal Medicine (1990)

Purpose: To evaluate the usefulness of screening for thyroid dysfunction in various clinical settings. Design: Review and synthesis of the literature. Main Results: Screening in the community detects new overt thyrotoxicosis or hypothyroidism in approximately 0.5% of the general population. The yield is best among women over 40 years of age (1%) and is lowest among young men (0%). Case-finding (testing clinic patients who are seeing a physician for unrelated reasons) has a better yield and is less expensive than screening in the community. Patients hospitalized with acute illnesses do not benefit from routine thyroid function testing. However, patients who are admitted to specialized geriatric units because of general disability, failure to thrive, and other indications may benefit. In various studies, from 2% to 5% of patients admitted to geriatric units have treatable thyroid disease. The serum total thyroxine, free thyroxine index, free thyroxine, and sensitive thyrotropin assay are all effective as initial tests for screening. The sensitive thyrotropin assay is less cost-effective than the other choices. Recommendations: Case-finding in some women over 40 years of age can be useful. Patients admitted to specialized geriatric units may also benefit from routine testing. Thyroid function tests are not indicated for community screening programs or for patients hospitalized with acute medical or psychiatric illnesses.
Generalized pustular psoriasis precipitated by trazodone in the treatment of depression
Authors: J.H. BARTH, H. BAKER
Journal: British Journal of Dermatology (1986)

Severe psoriasis is commonly associated with depression and may be its cause. The hazards of treating such patients with lithium are well known (Lazarus & Gilgor, 1979), but other drugs may also destabilize psoriasis. We report a patient in whom the anti‐depressant trazodone hydrochloride (Molipaxin®, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).
Bronchiolitis obliterans following lung transplantation: early detection using computed tomographic scanning
Authors: P A de Jong, J D Dodd, H O Coxson, C Storness-Bliss, P D Pare, J R Mayo, R D Levy
Journal: Thorax (2006)

Computed tomographic (CT) scanning may enable earlier diagnosis of chronic lung allograft dysfunction than forced expiratory volume in 1 second (FEV1). A study was undertaken to determine intra-observer and inter-observer agreement of composite and air trapping CT scores, to examine the association of FEV1 with the composite and air trapping CT score, and to relate the baseline composite CT score to changes in FEV1 and changes in the composite CT score over 1 year.Lung function and baseline CT scans following transplantation and at subsequent annual follow ups were analysed in 38 lung transplant recipients. Scans were randomly scored by two observers for bronchiectasis, mucus plugging, airway wall thickening, consolidation, mosaic pattern, and air trapping, and re-scored after 1 month. CT scores were expressed on a scale of 0-100 and correlated with FEV1 as a percentage of the post-transplant baseline value.The mean (SD) interval between baseline and follow up CT scans was 11.2 (4.7) months. Inter-observer and intra-observer agreement was good for both the composite and air trapping CT scores. There was a significant association between FEV1 and the composite CT score, with each unit of worsening in the baseline composite CT score predicting a 1.55% and 1.37% worsening in FEV1 over the following year (p<0.0001) and a 1.25 and 1.12 unit worsening in the composite CT score (p<0.0001) for observers 1 and 2, respectively.These findings indicate a potential role for a composite CT scoring system in the early detection of bronchiolitis obliterans.
Can Exercise Renography Be an Alternative to ACE Inhibitor Renography in Hypertensive Patients Who Are Suspicious for Renal Artery Stenosis?
Authors: Ayse Mudun, Okan Falay, Alpaslan Eryilmaz, Remzi Karaman, Sema Cantez
Journal: Clinical Nuclear Medicine (2004)

The aim of this study was to evaluate the value of Tc-99m ethylenedicysteine exercise renography in patients with hypertension who were suspicious for renal artery stenosis and compare the results with captopril renography. Methods: Twenty-nine patients with hypertension who were highly suspect for having renal artery stenosis were included in the study. Basal captopril exercise renograms were performed within 1 week in all patients with Tc-99m EC. Exercise was performed with a bicycle ergometer as described in the literature. Interpretations of renograms were made according to the consensus report on angiotensin converting enzyme (ACE) inhibitor renography as high, low, or intermediate probability. The sensitivity, specificity, and positive and negative predictive values were also obtained on both the kidneys and a patient basis. The results were compared with renal angiography in 19 patients. Results: Twenty of 29 patients had concordant results with both captopril and exercise studies. All discordant tests were normal with captopril but positive with exercise renograms. Nineteen patients with 38 kidneys were included for statistical data analysis. Nine kidneys, which were either atrophic or abnormal during the basal study, were excluded from the kidney-based analysis. With contrast angiography, 8 patients had renal artery stenosis. When evaluated on a kidney basis, the sensitivity, specificity, and positive and negative predictive values for captopril scans were 87%, 100%, 100%, and 95%, and for the exercise scans were 100%, 90%, 80%, and 100% respectively. When calculated on a patient basis with regard to the captopril scans, the sensitivity, specificity, and positive and negative predictive values were 87%, 81%, 77%, and 88%, and for exercise scans were 100%, 54%, 61%, and 100% respectively. There were 2 false-positive exercise scans that were found to be the result of dilated minor collecting systems and changes in kidney contours as a result of motion during exercise. Conclusions: These results indicate that exercise renography has a similar sensitivity but lower specificity compared with captopril scintigraphy in the diagnosis of renal artery stenosis. Because of the lower specificity, its use in the screening of renovascular hypertension may be limited. Exercise renography may be more useful as an investigative tool for essential hypertension.
Death by Malpractice: Who Are the Bad Guys?-Reply
Authors: Stanley Wohl
Journal: JAMA (1986)

In Reply.—  I make no apologies for having written the article in defense of a colleague. Every fact in the case history is accurate. In terms of the finer points of tort law raised by Mr Kramer, I make the following comments.  The relationship between a physician and his or her malpractice carrier is a matter determined by private contract. It is the common practice in every state for insurers and their lawyers to make the ultimate decision regarding the handling of an action brought against an insured physician for damages. The interests and the wishes of that physician are frequently subjugated to bottom-line considerations that include, but are not limited to, the projected costs of defending the action, the average damage award granted in the particular community under similar circumstances, and the wishes of co-defendants, often a hospital, named in the action. With the exception of the most obvious
The Effect of Simulated Cataract on the Glaucomatous Visual Field
Authors: Donald L. Budenz, William J. Feuer, Douglas R. Anderson
Journal: Ophthalmology (1993)

The current study is designed to determine the effect of light scattering (simulated cataract) on glaucomatous visual fields.Twelve patients with relative scotomas caused by glaucoma underwent the 30-2 threshold test with the Humphrey Visual Field Analyzer twice: once with and once without having a light-diffusing piece of ground glass in front of the eye, which, in previous experiments, has been shown to decrease perimetric threshold by 4.4 decibels (dB) in normal eyes. As controls, 12 patients underwent the same examination with and without a piece of clear glass in front of the eye. In each pair of fields, five points were analyzed within the relative scotoma and compared with five points in a normal area of the opposite hemifield.The diffusing ground glass produced a mean decrease of perimetric threshold of 5.7 dB (standard deviation [SD] = 3.3 dB) within the area of relative scotoma compared with 6.1 dB (SD = 2.4 dB) within the normal area and 4.4 dB (SD = 2.25 dB) at the fovea. The differences between means were not statistically significant. In addition, the diffusing glass did not affect the corrected pattern SD (CPSD) index (6.5 dB with the diffuser and 6.5 dB without).Light scattering depresses the glaucomatous visual field diffusely. Relative glaucomatous scotomas and normal areas are depressed equally, expressed as change in decibel of sensitivity. Therefore, in following patients with cataracts and glaucoma, depression of threshold sensitivity in glaucomatous areas out of proportion to normal areas should not be attributed to the light-scattering effect of the cataract, but rather to possible worsening of glaucomatous damage.
Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies
Authors: Dunrui Wang, Jill P. Buyon, Weiguo Zhu, Edward K.L. Chan
Journal: Journal of Clinical Investigation (1999)

Mothers of children with neonatal lupus erythematosus (NLE) and heart block, as well as patients with Sjögren's syndrome (SS) and systemic lupus erythematosus, have serum autoantibodies that recognize SS-A/Ro autoantigens including the 60-kDa ribonucleoprotein. By yeast 2-hybrid screening, we identified a novel 75-kDa protein (pp75) that interacts with the carboxyl 70% of 60-kDa SS-A/Ro. The specificity of interaction was confirmed using mammalian 2-hybrid and chemical crosslinking studies. Immunoprecipitation with radiolabeled HeLa cell extracts showed that pp75 was phosphorylated and associated with 2 other phosphoproteins of 64 kDa. In Northern blot analysis, pp75 was expressed in all tissues analyzed; the highest expression was in the human heart. Based on immunofluorescence of transfected HeLa cells, pp75 is localized predominantly in the cytoplasm, an observation confirmed by immunohistochemistry in untransfected cells. Based on Western blot and ELISA assays, sera from 14 of 84 mothers of children with NLE recognized pp75, including 1 mother in whom anti–SS-A/Ro antibodies were not detected. In addition, sera from 5 of 80 patients with SS were positive for anti-pp75 antibody. Identification of molecular partners is a first step toward elucidating the functions and possible involvement in pathogenesis of long-recognized autoantigens such as 60-kDa SS-A/Ro, which are at present poorly understood.