tbuckley/cabot-search huggingface dataset:
Relationship Between Market Competition and the Activities and Attitudes of Medical School Faculty
Authors: Eric G. Campbell
Journal: JAMA (1997)

Growth in health care market competition and the concomitant increasing dependence of academic health centers on clinical revenues may require medical school faculty to increase patient care activity, perhaps at the expense of research and teaching. However, the relationship between health care market competitiveness and the activities and attitudes of medical school faculty has not been established.To examine the relationship between market competitiveness and the activities and attitudes of medical school faculty members.Mailed survey of 3394 life-science faculty in the 50 universities that received the most funding from the National Institutes of Health in 1993.Medical schools in research-intensive universities.A total of 2167 faculty responded to the survey (response rate, 64%). We analyzed the responses of 1671 medical school research faculty located in markets of differing health care competitiveness, ranging from least competitive (stage 1) to most competitive (stage 4) markets.The number of publications in refereed journals in the last 3 years, the average number of hours per week of teaching contact, whether faculty in clinical departments had patient care responsibilities, and measures of departmental community, cooperation, and conflict.Clinical researchers in stage 1 and 2 markets published more scientific articles than those in stage 3 markets (14.5 vs 12.6, P=.04) or in stage 4 markets (14.5 vs 12.0, P=.03). Among 96 young faculty (professional age-<10 years) in clinical departments, 11 (44%) of those in stage 1 and 2 markets had patient care duties compared with 32 (56.1%) of young faculty members in stage 3 markets (P=.04) and 12 (85.7%) of those in stage 4 markets (P=.01). The percentage of senior faculty in clinical departments (n=691) with patient care responsibilities did not differ significantly by market stage. Compared with faculty in less competitive markets, faculty in stage 4 markets perceived lower levels of departmental cooperation and higher levels of conflict.Increased competitiveness of health care markets seems to hinder the capacity of academic health centers to conduct clinical research and to foster the careers of young clinical faculty.
Regulation, Role, and Targeting of Akt in Cancer
Authors: Michael A. Davies
Journal: Journal of Clinical Oncology (2011)

Article Tools UNDERSTANDING THE PATHWAY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2011.37.4751 Journal of Clinical Oncology - published online before print October 24, 2011 PMID: 22025159 Regulation, Role, and Targeting of Akt in Cancer Michael A. DaviesxMichael A. DaviesSearch for articles by this author Show More The University of Texas MD Anderson Cancer Center, Houston, TX https://doi.org/10.1200/JCO.2011.37.4751 First Page Full Text PDF Figures and Tables © 2011 by American Society of Clinical Oncology
Hepatitis B virus DNA integration in tumour tissue of a non-cirrhotic HFE-haemochromatosis patient with hepatocellular carcinoma
Authors: Teresa Pollicino, Alberto Vegetti, Carlo Saitta, Francesca Ferrara, Elena Corradini, Giuseppina Raffa, Antonello Pietrangelo, Giovanni Raimondo
Journal: Journal of Hepatology (2012)
Circulation prints correction to clinical trial at centre of libel action
Authors: M. Pownall
Journal: BMJ (2009)

The American Heart Association’s journal Circulation has issued a lengthy correction to a clinical trial at the centre of a libel action directed against a UK cardiologist. It has also replaced the original study with a corrected version on its website.

The correction ( Circulation 2009;120:e71-2, doi:10.1161/CIRCULATIONAHA.109.192626) says that the migraine intervention with STARFlex technology (MIST) trial, originally published in March last year ( Circulation 2008;117:1397-1404, doi:10.1161/CIRCULATIONAHA.107.727271), had “a number of errors and omissions.”

The libel suit, against Peter Wilmshurst, a consultant cardiologist at Shrewsbury Hospital, followed comments he was reported to have made to a cardiology website (http://theheart.org) about the trial, of which he was a joint principal investigator.

The MIST trial aimed to see whether closing a patent foramen ovale with the STARFlex implant would reduce or eliminate …
Why do house jobs always start on the same day?
Authors: J A McGarry
Journal: BMJ (1989)

three patients who required vitrectomy in the past 12 months were from this district (which has a population of 400 000).Sufficient treatment is hard to define but includes assessment of location, size, and number of effective burns; the counter on the laser photocoagulator is not a good guide.Never- theless, patients often need more than the 2000 burns that Dr Richardson and his colleagues regard as being indisputably adequate, and even as many as 13000 burns have been necessary and effective on occasion.2Although it is gratifying to have the technology to salvage some vision in patients with late complications of diabetic retinopathy, how much better it would be to prevent these complications in the first place.Screening for sight threatening diabetic retinopathy followed by timely, adequate photo- coagulation is effective in minimising blindness; vitrectomy should become a rare sign of failure of this service.Diabetes is the commonest cause of registrable blindness in people of working age.Provision of screening and photocoagulation services for diabetic retinopathy must merit a high priority in every district.
Emerging Assets and Liabilities of a Committee on Human Welfare and Experimentation
Authors: Kenneth L. Melmon, Michael Grossman, R. Curtis Morris
Journal: New England Journal of Medicine (1970)

Abstract The University of California San Francisco Medical Center Committee on Human Welfare and Experimentation has reviewed 340 applications for research involving human beings during its first two years of operation. The Committee delegated review to three-man ad hoc groups selected on the basis of expertise and objectivity. Seventeen protocols were rejected by at least two ad hoc committees because risk-benefit ratio could not be assessed (seven), because of inadequate precautions (eight) and because of unacceptable risk (two). The decisions of the Committee were on the whole well accepted, ad hoc groups have increasingly adopted the standards defined by the parent Committee, and wide involvement of the faculty in the reviewing process has led to greater recognition of the legal and moral obligations incurred by those who study man.
The Marihuana Problem: An Overview
Authors: WILLIAM H. MCGLOTHLIN, LOUIS JOLYON WEST
Journal: American Journal of Psychiatry (1968)

Current knowledge of the use of marihuana, its physical and mental effects, and its relation to crime and to other drug use are reviewed. The authors feel that a reappraisal of the social and legal policies regarding marihuana use is needed to resolve the crisis brought about by the rapid increase in its use despite the severe penalties prescribed for violation of the marihuana laws.
Recombinant human G-CSF increases invasiveness of breast cancer cells.
Authors: DJ Webster, ZJ Wilde, AR Orzol, JL Davis, ML Troxell, D Bae
Journal: Cancer Research (2009)

Abstract Abstract #4057 Background: Recombinant human granulocyte-colony stimulating factor (rhG-CSF) is commonly given to breast cancer patients to prevent neutropenia during chemotherapy. It binds to the G-CSF receptor (G-CSFR) on neutrophil precursors, promoting their proliferation within the bone marrow. We observed breast cancer growth in patients with advanced breast cancer during rhG-CSF administration. The G-CSFR is present on some solid tumors, but has not been examined in breast cancer. We asked whether breast cancer cells express the G-CSFR, and whether rhG-CSF has any direct effects on breast cancer proliferation or invasion in vitro.&amp;#x2028; Material and Methods: MDA MB231 is a highly aggressive ER–PR–Her2/neu– breast cancer cell line derived from a human pleural effusion. We analyzed this cell line for the presence of the G-CSFR by immunohistochemistry, reverse-transcriptase PCR (RT-PCR), Western Blot analysis and flow cytometry. We sequenced DNA products of RT-PCR to verify results. We examined the effects of physiologic doses of rhG-CSF on breast cancer cell proliferation and invasion using MTT proliferation and Matrigel transwell assays, respectively.&amp;#x2028; Results: MDA MB231 breast cancer cells express G-CSFR protein and mRNA. Of seven known G-CSFR isoforms, we found evidence of isoforms 1 and 4. Treating MDA MB231 breast cancer cells with rhG-CSF at 50ng/ml did not increase cell proliferation, but did increase invasion across a Matrigel-coated transwell membrane. Cells treated with rhG-CSF appeared more stellate than untreated cells. Studies are ongoing to evaluate which signal transduction pathways and genes are involved in this increased invasion response. The effects of rhG-CSF on breast cancer growth in vivo are also being examined in murine models.&amp;#x2028; Discussion: rhG-CSF is given routinely as part of many adjuvant chemotherapy regimens for breast cancer. Although dose-dense regimens using rhG-CSF have shown equivalent or improved survival when compared to standard dosing regimens, it is possible that rhG-CSF may increase the growth or invasive potential of some breast cancers. It is also possible that rhG-CSF could mobilize breast cancer cells from the bone marrow, making these cells more susceptible to chemotherapy. These possibilities should promote thoughful use of rhG-CSF in the clinical setting, and should factor into the design and implementation of clinical trials using rhG-CSF. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 4057.
A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma
Authors: Hayriye V Erkizan, Yali Kong, Melinda Merchant, Silke Schlottmann, Julie S Barber-Rotenberg, Linshan Yuan, Ogan D Abaan, Tsu-hang Chou, Sivanesan Dakshanamurthy, Milton L Brown, Aykut Üren, Jeffrey A Toretsky
Journal: Nature Medicine (2009)
Gangrene of the Extremities of Venous Origin
Authors: HENRY HAIMOVICI
Journal: Circulation (1950)

Gangrene of the extremities of venous origin is reviewed; it is a rare but distinct clinicopathologic entity hitherto not widely known. A classification of the cases of thrombophlebitis complicated with gangrene is presented, based on the presence of the peripheral pulses: (1) cases with palpable arteries; (2) cases with nonpalpable but patent arteries. Patency of the entire arterial system of the involved extremity, as verified by anatomic findings, is necessary for correct diagnosis. Complete blockage of the venous system appears to be the initiating and main cause, angiospasm playing a secondary role. The gangrene usually remains superficial and limited. Hence, a conservative surgical attitude is emphasized.
Salt-Sensitive Hypertension Induced by Decoy of Transcription Factor Hypoxia-Inducible Factor-1α in the Renal Medulla
Authors: Ningjun Li, Li Chen, Fan Yi, Min Xia, Pin-Lan Li
Journal: Circulation Research (2008)

Hypoxia inducible factor (HIF)-1α, a transcription factor, is abundantly expressed in the renal medulla and regulates many oxygen-sensitive genes such as nitric oxide synthase, cyclooxygenase-2, and heme oxygenase-1. Given the important roles of these genes in the control of arterial pressure, the present study was to test the hypothesis that HIF-1α–mediated gene activation serves as an antihypertensive pathway by regulating renal medullary function and sodium excretion. HIF-1α decoy oligodeoxynucleotides (ODNs) or scrambled ODNs were transfected into the renal medulla in uninephrectomized Sprague–Dawley rats. Two weeks after ODN transfection, the HIF-1α binding activities were significantly inhibited by 45%, and high salt–induced increases of nitric oxide synthase-2 and heme oxygenase-1 transcriptions were also inhibited by 70% and 61% in the renal medulla from decoy rats. The natriuretic responses and increases of renal medullary blood flow responding to the elevations of renal perfusion pressure were significantly blunted by 50% and 37% in decoy rats. Intravenously acute sodium loading increased medullary blood flow and urinary sodium excretion, which was remarkably attenuated in decoy rats. In decoy rats, high salt intake caused a greater positive sodium balance. Consequently, arterial pressure was remarkably increased (from 118±1.9 to 154±6.3 mm Hg) in decoy rats but not in control rats when the rats were challenged with a high salt diet. There was no blood pressure change in decoy rats that were maintained in normal salt diet. In conclusion, HIF-1α–mediated gene activation importantly participates in the regulation of renal medullary function and long-term arterial blood pressure.
Pregnancy order and fetal loss.
Authors: P Yudkin
Journal: BMJ (1980)

To determine the effect of a particular variable on the risk of fetal loss, it is important to examine the changes in risk when that factor is allowed to vary while holding all other relevant variables constant. Variables such as maternal age and social class may pose some difficulty because of scarcity of data. Using the variable 'pregnancy order' may be difficult too as it is not possible to allow 'pregnancy order' to vary while holding all other relevant variables constant. If 'pregnancy order' is permitted to vary, the 'number of previous pregnancy outcomes' must be allow to vary too. If the effect of the variable 'number of previous outcomes' on the risk of fetal loss in current pregnancy were investigated, this variable should be allowed to vary while holding all other relevant variables constant. One of the relevant variables known, however, is previous pregnant history (descriptive set of previous outcomes, including number, type and order of these outcomes); in which case it should be allowed to vary if the number of previous outcomes were to vary. It thus seems that the only quantifiable variable which affects risk is the conglomerate variable 'previous pregnancy history'. To arrive at general conclusions, the risk rates specific to particular 'previous pregnancy histories' may be aggregated in a number of ways (eg., to the number of previous outcomes using population weighting). In other cases, other features of previous pregnnacy history may have been obscured by other studies on pregnancy order, in which case aggregation should be done by type, not number of previous outcomes.
Acute Myeloblastic Leukemia After Cure of Ovarian Cancer
Authors: Ezra M. Greenspan
Journal: JAMA (1974)

Two patients with advanced stage III ovarian cancer had complete regressions after intensive therapy with thiotepa and methotrexate. Both patients showed unusual sensitivity while on maintenance doses of thiotepa. Marrow hypoplasia occurred for several years before gradual development of myeloblastic leukemia, five years after apparent cure of the ovarian neoplasm. These two patients represent 15% of a group of 14 patients surviving five years without clinical recurrence among a total of 400 ovarian cancers treated with chemotherapy since 1959. (<i>JAMA</i>230:418-423, 1974
I-123 Metaiodobenzylguanidine (MIBG) in Sympathetic Denervation and Reinnervation of Salivary Glands in a Child With Cervical Neuroblastoma
Authors: Efstratios Moralidis, Georgios Arsos, Eugenia Papakonstantinou, Dimitrios Koliouskas, Constantinos Karakatsanis
Journal: Clinical Nuclear Medicine (2008)

Asymmetric I-123 MIBG uptake in salivary glands in children with cervical neuroblastoma has been reported previously, in association with Horner syndrome. We present the case of a 9-month-old male infant with a surgically excised right-sided cervical neuroblastoma, no manifestations of oculosympathetic paresis, and no visualization of the right-sided salivary glands in postoperative I-123 MIBG imaging. Six months later faint I-123 MIBG uptake was observed in the right parotid and submandibular salivary glands and this became more intense in subsequent scans. These findings are consistent with sympathetic denervation and reinnervation of the salivary glands and illustrate the plasticity of the sympathetic nervous system.
The Spectrum of Columnar-Lined Esophagus-Barrett's Esophagus
Authors: G. N. J. Tytgat, W. Hameeteman, R. Onstenk, R. Schotborg
Journal: Endoscopy (1989)

Definition, developpement, aspects endoscopiques de l'œsophage de Barrett. Formation de polypes adenomateux et association a l'epithelioma glandulaire
Kock Urinary Reservoir Maturation in Children and Adolescents: Consequences for Kidney and Upper Urinary Tract
Authors: G. Abd-el-Gawad, K. Abrahamsson, E. Hanson, L. Norl&eacute;n, U. Sill&eacute;n, E. Stokland, K. Hj&auml;lm&aring;s
Journal: European Urology (1999)
Case 46-1978
Authors: Edward A. Gaensler, Eugene J. Mark
Journal: New England Journal of Medicine (1978)

Presentation of CaseA 58-year-old man was admitted to the hospital because of recurrent left pleural effusions.He was well until 10 months previously, when pain developed in the left side of the chest accompanied by a nonproductive cough, anorexia and loss of weight. Three months later the symptoms worsened, and he entered another hospital. Atrial fibrillation was found. X-ray films of the chest showed blunting of the left costophrenic angle, believed to result primarily from scarring; a small amount of pleural fluid was evident on lateral decubitus projections. A tuberculin skin test was positive. Six months before admission he . . .
Bitopertin
Authors: Donald C. Goff
Journal: JAMA Psychiatry (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Disseminated Scotochromogen Infection and Unusual Myeloproliferative Disorder
Authors: DAVID R. MCNUTT
Journal: Annals of Internal Medicine (1971)

The patient described in this report presented with an unusual form of a myeloproliferative disorder; during therapy she developed disseminated scotochromogen infection. The case is of interest for two reasons: it documents the transition from hemorrhagic thrombocythemia to chronic granulocytic leukemia, and it calls attention to an unusual mycobacterium that previously had not been considered an opportunistic infectious agent.
Novel FISH probes designed to detect IGK-MYC and IGL-MYC rearrangements in B-cell lineage malignancy identify a new breakpoint cluster region designated BVR2
Authors: R R Einerson, M E Law, H E Blair, P J Kurtin, R F McClure, R P Ketterling, H C Flynn, A Dogan, E D Remstein
Journal: Leukemia (2006)
LY2875358, a Neutralizing and Internalizing Anti-MET Bivalent Antibody, Inhibits HGF-Dependent and HGF-Independent MET Activation and Tumor Growth
Authors: Ling Liu, Wei Zeng, Mark A. Wortinger, S. Betty Yan, Paul Cornwell, Victoria L. Peek, Jennifer R. Stephens, Jonathan W. Tetreault, Jinqi Xia, Jason R. Manro, Kelly M. Credille, Darryl W. Ballard, Patricia Brown-Augsburger, Volker Wacheck, Chi-Kin Chow, Lihua Huang, Yong Wang, Irene Denning, Julian Davies, Ying Tang, Peter Vaillancourt, Jirong Lu
Journal: Clinical Cancer Research (2014)

MET, the receptor for hepatocyte growth factor (HGF), has been implicated in driving tumor proliferation and metastasis. High MET expression is correlated with poor prognosis in multiple cancers. Activation of MET can be induced either by HGF-independent mechanisms such as gene amplification, specific genetic mutations, and transcriptional upregulation or by HGF-dependent autocrine or paracrine mechanisms.Here, we report on LY2875358, a novel humanized bivalent anti-MET antibody that has high neutralization and internalization activities, resulting in inhibition of both HGF-dependent and HGF-independent MET pathway activation and tumor growth. In contrast to other bivalent MET antibodies, LY2875358 exhibits no functional agonist activity and does not stimulate biologic activities such as cell proliferation, scattering, invasion, tubulogenesis, or apoptosis protection in various HGF-responsive cells and no evidence of inducing proliferation in vivo in a monkey toxicity study. LY2875358 blocks HGF binding to MET and HGF-induced MET phosphorylation and cell proliferation. In contrast to the humanized one-armed 5D5 anti-MET antibody, LY2875358 induces internalization and degradation of MET that inhibits cell proliferation and tumor growth in models where MET is constitutively activated. Moreover, LY2875358 has potent antitumor activity in both HGF-dependent and HGF-independent (MET-amplified) xenograft tumor models. Together, these findings indicate that the mechanism of action of LY2875358 is different from that of the one-armed MET antibody.LY2875358 may provide a promising therapeutic strategy for patients whose tumors are driven by both HGF-dependent and HGF-independent MET activation. LY2875358 is currently being investigated in multiple clinical studies.
Computed Tomographic Screening for Lung Cancer—Reply
Authors: Peter B. Bach
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
IMPAIRED SARCOLEMMAL CALCIUM EXTRUSION RESERVE AS A MAJOR CAUSE FOR INCOMPLETE RELAXATION AND TACHYCARDIA-INDUCED CONTRACTURES IN MYOCARDIUM FROM PATIENTS WITH CONCENTRIC LEFT VENTRICULAR HYPERTROPHY
Authors: Don E. Selby, Martin M. LeWinter, Markus Meyer
Journal: Journal of the American College of Cardiology (2011)