tbuckley/cabot-search huggingface dataset:
L.M.C. Resolution on Group Practice Loans Fund
Authors: R. Alexander, D. Anniss, H. V. Blake, F. B. Briggs, P. J. Bryce-Curtis, H. C. I. Bywater, J. R. Caldwell, G. F. M. Carnegie, J. A. A. Chamberlain-Webber, B. W. Christopher, J. O. Collin, D. E. Dart, E. J. Dennison, G. Dormand, D. Faro, M. J. Gilkes, R. W. Glenn, D. Godwin, D. J. Gooding, P. F. Gray, R. Green, G. C. Gundersen, M. Hall, J. L. Hartley, N. W. A. Harvey, J. D. W. Hunter, R. M. Lodge, J. W. Murdoch, C. R. Palmer, C. Ruck, F. R. Ryle, E. G. Sibley, R. B. Tulk-Hart, W. F. d. C. Veale, J. R. Wright
Journal: BMJ (1970)

wounds.'However, the treatment involves multiple injections and preparation of sera
GLUCOSE INTRAVENOUSLY AS A THERAPEUTIC MEASURE
Authors: LAWRENCE LITCHFIELD
Journal: JAMA (1918)

In combating serious diseases, besides the specific effects of the invading micro-organisms, we have to deal with three very important conditions, dehydration, intoxication (from retention of waste products) and nitrogen starvation. The picture is a very complex one, and I shall not attempt to analyze and disentangle all the component signs and symptoms. It seems to me that dehydration is the least appreciated and therefore the most potent for evil. Three fifths of the body weight is water. A man will succumb to the deprivation of water in a few days, while he can survive the deprivation of food for forty days or more. Water is needed to maintain the volume of the blood necessary for the mechanical efficiency of the circulatory apparatus, to carry nourishment to the cells, to carry away in solution the waste products of metabolism, and to maintain the proper solutions and osmotic conditions essential to
Cardiac Magnetic Resonance Features of Biopsy-Proven Endomyocardial Diseases
Authors: Martina Perazzolo Marra, Gaetano Thiene, Stefania Rizzo, Manuel De Lazzari, Elisa Carturan, Francesco Tona, Alida Linda Caforio, Luisa Cacciavillani, Renzo Marcolongo, Giuseppe Tarantini, Francesco Corbetti, Sabino Iliceto, Cristina Basso
Journal: JACC. Cardiovascular imaging (2014)
Hormonal Regulation of Cyclic Nucleotide Phosphodiesterases*
Authors: MARCO CONTI, S.-L. CATHERINE JIN, LUCIA MONACO, DAVID R. REPASKE, JOHANNES V. SWINNEN
Journal: Endocrine Reviews (1991)

ACOMPLEX array of signals from the extracellular environment regulate many cell processes, including the entry and exit from the mitotic cycle and the induction and maintenance of differentiation (1–3). Cells elaborate these external stimuli via receptors, transducers, and second messengers (4, 5) which control intricate circuits that lead to protein phosphorylation by protein kinases (6, 7). Although novel second messenger pathways have been discovered and dissected in some detail in the past 10 years (8, 9), cyclic nucleotides (cAMP and cGMP) remain the best characterized second messengers, and their role in the differentiation and control of metabolic processes of the endocrine cell is widely recognized. The components of the membrane-associated machinery that transduces external signals into changes in cyclic nucleotide levels have been isolated and characterized. These include many members of the family of membrane receptors (10–14), G proteins acting as transducers (15, 16), and adenylate cyclase effectors (15, 17). Furthermore, complementary DNAs that encode these components are becoming available (10–17), thus opening new avenues by which to study the structure and function of these membrane-associated, protein complexes.
Chronic Respiratory Failure in Infants With Prolonged Ventilator Dependency
Authors: Mark S. Schreiner
Journal: JAMA (1987)

One hundred one infants with chronic respiratory failure (CRF) who required prolonged mechanical ventilation were cared for in the pediatric intensive care unit at The Children's Hospital of Philadelphia between January 1967 and December 1984. Chronic respiratory failure of infancy is a condition that requires mechanical ventilation for more than 28 days in the first year of life. Thirty-six children had severe bronchopulmonary dysplasia, 50 had congenital anomalies, and 15 had neuromuscular disorders. The mean duration of mechanical ventilation for the 101 patients was 12.3 months. Seventy-one children were alive, and 53 (75%) of the 71 had been weaned from mechanical ventilation as of Dec 31, 1984. Pulmonary insufficiency and cardiac failure were the predominant causes of death in 17 of 22 infants in the first two years after the onset of CRF; four of eight deaths that occurred beyond two years were caused by airway- and ventilator-related accidents. Mechanical ventilatory support was emphasized for as long as necessary to provide normal blood gas tensions, nutrition, growth, and development rather than weaning as rapidly as possible. This clinical experience demonstrates that it is feasible to save over 70% of infants with the severest forms of CRF and prolonged ventilator dependency. (<i>JAMA</i>1987;258:3398-3404)
EB virus antibody at different ages
Authors: M. S. Pereira, J. M. Blake, A. D. Macrae
Journal: BMJ (1969)

In relation to the study of infectious mononucleosis a survey of the prevalence of antibody to EB virus was made on the sera of persons of varying age from several different areas in England by the indirect immunofluorescence technique. About half those tested were found to have acquired antibody by the age of 4 years and there was a further significant increase in the proportion of those positive between the ages of 15 and 24 years. The finding of seroconversion in two patients who developed infectious mononucleosis provides further support for an association between EB virus and this condition.
Multiple Brown Tumors in Parathyroid Carcinoma Mimicking Metastatic Bone Disease
Authors: MOONSUN PAI, CHAN H. PARK, BYOUNG-SUCK KIM, YOON-SOK CHUNG, AND HEE-BOONG PARK
Journal: Clinical Nuclear Medicine (1997)

An unusual case of multiple brown tumors due to parathyroid carcinoma is reported. The patient presented with lower leg pain. Plain radiographs demonstrated multiple lytic lesions of the lower legs and a Tc-99m MDP bone scan depicted multiple areas of increased uptake suggesting skeletal metastases. Tc-99m sestamibi tumor scintigraphy showed multiple sites of tumor uptake in bones and a large area of increased uptake with a cystic component in the right lower pole of the thyroid gland. An open biopsy from the right tibial lesion revealed a brown tumor. A large parathyroid carcinoma with a necrotic cyst was removed. After parathyroidectomy and right thyroid lobectomy, the patient became free of bone pain and serum PTH levels normalized. A 9-month follow-up Tc-99m MDP bone scan demonstrated less intense uptake in the pelvis, tibia, and fibulae. Nine-month follow-up tumor imaging with Tc-99m MIBI revealed disappearance of the preoperative uptake of multiple brown tumor.
Counselling needs and experience of junior hospital doctors.
Authors: P Garrud
Journal: BMJ (1990)

A sample of 106 senior house officers who had graduated from Nottingham University in 1987 was surveyed about their experience of and need for careers guidance, performance appraisal, and stress counselling. Of the 80 who replied, a quarter had received no careers guidance and a quarter no feedback about their work performance. Many reported having had difficulties in their post, but few had received help from senior staff or their consultant. The perceived needs for counselling were considerable. Careers counselling was thought to be essential in the preregistration year by all of the doctors and in senior house officer posts by three quarters. Nearly all would have chosen regular appraisal and nearly half wanted counselling for particular difficulties. Doctors in the training grades clearly believed that they needed counselling, but in most cases they did not receive it.
Lincoln’s Sign
Authors: Chandra Sekhar Bal, Manas Kumar Sahoo, Nishikant Damle
Journal: Clinical Nuclear Medicine (2013)

Classical appearance of “Lincoln’s sign” on 99mTc-MDP bone scintigraphy has been described in literature in case of monostotic Paget disease of mandible showing increased radiotracer uptake in the body of mandible. This pattern has also been described as “black beard” sign. The monostotic presentation of Paget disease is rare, and involving the mandible, however, is very unusual. We present a case of carcinoma of the tongue with contiguous spread to the mandible presented in the similar fashion as the earlier reported Lincoln’s sign or black beard sign on 99mTc-MDP bone scintigraphy. This appearance was confirmed with SPECT/CT, and the lytic sclerotic lesion of the mandible was confirmed.
P1181 CEREBRAL GLUCOSE METABOLISM AND NEUROPSYCHIATRIC SYMPTOMS IN CHRONIC HEPATITIS C PATIENTS WITH INTERFERON THERAPY
Authors: K. Sawara, T. Wang, Y. Yoshida, A. Miyasaka, T. Oikawa, Y. Kooka, H. Kuroda, K. Kasai, A. Kato, K. Suzuki, Y. Takikawa
Journal: Journal of Hepatology (2014)
Magnesium Metabolism in Hypertensive Cardiovascular Disease.
Authors: Robert H. Seller
Journal: Annals of Internal Medicine (1965)

s1 May 1965Magnesium Metabolism in Hypertensive Cardiovascular Disease.Robert H. Seller, M.D., Osvaldo Ramirez-Muxo, M.D., Albert N. Brest, M.D., F.A.C.P., John H. Moyer III, M.D., F.A.C.P.Robert H. Seller, M.D.Search for more papers by this author, Osvaldo Ramirez-Muxo, M.D.Search for more papers by this author, Albert N. Brest, M.D., F.A.C.P.Search for more papers by this author, John H. Moyer III, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1072_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIncreased vascular smooth muscle tone and the associated changes in transmembrane potential are thought to be a major factor in the development and maintenance of hypertension. Magnesium affects transmembrane potential, and hypomagnesemia has been reported in essential hypertension and primary aldosteronism associated with hypertension.To determine the significance of magnesium metabolism in the pathogenesis and treatment of hypertension serum and erythrocytic magnesium, calcium, sodium, and potassium as well as serum urea nitrogen, creatinine, phosphorus, chloride, and carbon dioxide were determined in 20 normal subjects and in 16 hypertensive patients before and after 12 weeks of hydrochlorothiazide therapy. Atomic absorption spectroscopy... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1072-1072KeywordsHypertensionHypomagnesemiaMagnesiumMembrane potentialPathogenesisPhosphorusPotassiumSerum urea nitrogenSmooth musclesSodium Issue Published: 1 May 1965 PDF DownloadLoading ...
Management of Venous Thromboembolism: A Systematic Review for a Practice Guideline
Authors: Jodi B. Segal, Michael B. Streiff, Lawrence V. Hofmann, Katherine Thornton, Eric B. Bass
Journal: Annals of Internal Medicine (2007)

Background: New treatments are available for treatment of venous thromboembolism. Purpose: To review the evidence on the efficacy of interventions for treatment of deep venous thrombosis (DVT) and pulmonary embolism. Data Sources: MEDLINE, MICROMEDEX, the Cochrane Controlled Trials Register, and Cochrane Database of Systematic Reviews from the 1950s through June 2006. Study Selection: Randomized, controlled trials; systematic reviews of trials; and observational studies; all restricted to English-language articles. Data Extraction: Paired reviewers assessed study quality and abstracted data. The authors pooled results about optimal duration of anticoagulation. Data Synthesis: This review includes 101 articles. Low-molecular-weight heparin (LMWH) is modestly superior to unfractionated heparin at preventing recurrent DVT and is at least as effective as unfractionated heparin for treatment of pulmonary embolism. Outpatient treatment of venous thromboembolism is likely to be effective and safe in carefully chosen patients, with appropriate services available. Inpatient or outpatient use of LMWH is cost-saving or cost-effective compared with unfractionated heparin. In observational studies, catheter-directed thrombolysis safely restored vein patency in select patients. Moderately strong evidence supports early use of compression stockings to reduce postthrombotic syndrome. Limited evidence suggests that vena cava filters are only modestly efficacious for prevention of pulmonary embolism. Conventional-intensity oral anticoagulation beyond 12 months may be optimal for patients with unprovoked venous thromboembolism, although patients with transient risk factors benefit little from more than 3 months of therapy. High-quality trials support use of LMWH in place of oral anticoagulation, particularly in patients with cancer. Little evidence is available to guide treatment of venous thromboembolism during pregnancy. Limitations: The authors could not address all management questions, and excluded non–English-language literature. Conclusions: The strength of evidence varies across the study questions but generally is strong.
Dual IHC and FISH Testing for ALK Gene Rearrangement in Lung Adenocarcinomas in a Routine Practice: A French Study
Authors: Anne McLeer-Florin, Denis Moro-Sibilot, Adrien Melis, Dimitri Salameire, Christine Lefebvre, Françoise Ceccaldi, Florence de Fraipont, Elisabeth Brambilla, Sylvie Lantuejoul
Journal: Journal of Thoracic Oncology (2011)
Employment Contracts Between House Officers and Hospitals
Authors: Stuart C. Cullen
Journal: JAMA (1970)

That there is a genuine, wide-spread and justifiable activity on the part of house staffs throughout the country for increased income and fringe benefits is well established. Administration is confronted with the problem of developing means of assessing these needs and meeting the agreed upon goals. In the process of assessing and meeting the needs, communication between administration and house staff is vital to a sensible, defensible and practical solution. Productive communication is contingent upon house staff and administration designating people with the authority to speak for and who have the backing of the organization they represent. These people must be the sort of people who can communicate in times of stress and emotional provocatives on an objective and frank and direct basis. Memos and letters are necessary to affirm actions taken in conference but should not be the sole or primary means of communication. In the negotiations that we
Blockade of Angio-Associated Migratory Cell Protein Inhibits Smooth Muscle Cell Migration and Neointima Formation in Accelerated Atherosclerosis
Authors: Felix Vogt, Alma Zernecke, Marie Beckner, Nicole Krott, Anja-Katrin Bosserhoff, Rainer Hoffmann, Marc A.M.J. Zandvoort, Thomas Jahnke, Malte Kelm, Christian Weber, Rüdiger Blindt
Journal: Journal of the American College of Cardiology (2008)
SYSTOLIC ANTERIOR MOTION OF THE ANTERIOR MITRAL LEAFLET AND HYPERTROPHIC CARDIOMYOPATHY: A PREDICTOR OF NON-GENETIC, NON-FAMILIAL DISEASE?
Authors: Beth Ann Medford, Kristina Haugaa, Johan Bos, Angela Miller, Steve Ommen, Bernard Gersh, Jonathan Johnson, Frank Cetta, Benjamin Eidem, Patrick O'Leary
Journal: Journal of the American College of Cardiology (2013)
Giving clinicians managerial responsibility can improve quality, think tank says
Authors: N. Hawkes
Journal: BMJ (2012)

Giving hospital consultants responsibility for managing their own services can improve quality and efficiency and can also identify how well the services perform and what they cost, the healthcare think tank the King’s Fund concludes in a new report. 

But to make it possible, boards and senior executives have to cede control and power to clinical teams.

Service line management, a concept first introduced into healthcare in the United States and championed by Monitor, England’s regulator of foundation trusts, devolves decision making in hospitals to distinct operational units centred on a particular service. The system aims to make better use of information and increase clinicians’ engagement in managing services. The King’s Fund report includes interviews with staff at seven NHS trusts that have used service line management to a greater or lesser degree.

The report …
How Should Results from Completed Studies Influence Ongoing Clinical Trials?
Authors: Andreas Laupacis, Stuart J. Connolly, Michael Gent, Robin S. Roberts, John Cairns, Campbell Joyner
Journal: Annals of Internal Medicine (1991)

Seven randomized studies during the past 5 years have evaluated or are evaluating the efficacy of warfarin or aspirin or both in decreasing the risk of embolic events in patients with nonrheumatic atrial fibrillation. By March 1990, two of the studies had been published, both of which showed a statistically significant decrease in embolic events in patients treated with warfarin and a low rate of major bleeding events. The investigators associated with the other ongoing studies were forced to consider how these results should affect the decision to recruit and continue follow-up of patients in their own studies. The Steering Committee of the Canadian Atrial Fibrillation Anticoagulation (CAFA) study thought the newly published results from other studies were valid, clinically important, and generalizable. The committee considered the following options for the CAFA study: continue patient recruitment as planned, provide the data available in CAFA to its External Safety and Efficacy Monitoring Committee for analysis to determine whether the CAFA data already showed a benefit of warfarin, stop patient recruitment but continue to follow patients in the group to which they were assigned, stop the trial immediately and perform a final analysis, and attempt to perform a meta-analysis of all data available from all trials. The Steering Committee of CAFA decided that the evidence of benefit with warfarin, from the two published studies, was sufficiently compelling as to stop recruitment into CAFA without any preliminary examination of the CAFA data.
THE ANALYSIS OF STREPTOCOCCAL INFECTIONS
Authors: Seymour P. Halbert, Suzanne L. Keatinge
Journal: The Journal of Experimental Medicine (1961)

It has been found by immunoelectrophoresis, that Group A streptococci release at least 20 distinct extracellular antigens in human tissues, as judged by naturally occurring antibodies present in normal pooled human gamma globulin. Several of these precipitin arcs have been identified with streptococcal antigens previously purified by electrophoresis and chromatography. Human gamma globulin, as well as several rheumatic fever sera, were shown to be remarkably potent in antistreptococcal antibodies, when compared to four horse antibody concentrates obtained by hyperimmunization with several streptococcal filtrates. A Group C streptococcal culture concentrate revealed 8 or 9 antigens for which corresponding antibodies were present in human gamma globulin.
Two Cases of Haematological Interest
Authors: I. MacKay
Journal: BMJ (1939)

The following two cases are considered uncommon enough to merit publication. The first is that of a healthy adult in whose blood macropolycytes have been observed over a period of four years. The second is a case of agranulocytosis in which marked erythrophagocytosis occurred in the circulation following blood transfusion. Photomicrographs of the blood in each case are repro duced (Plate: Case I, Figs. 1-3 and 5-8; Case II, Figs. 9-15).
Potentiation of vincristine cytotoxicity by hormones: Corticosteroids, androgens, estrogens and progestins
Authors: Fred Rosner, Yashar Hirshaut, Hans W. Grünwald, Stanley Deutsch
Journal: American Journal of Hematology (1978)

Abstract Using an in vitro system to evaluate the simultaneous use of two drugs, we previously have confirmed the synergism of vincristine and prednisolone cytotoxicity against lymphoid cells. Experiments were now carried out to determine whether other steroid hormones can be substituted for prednisolone. Partial or complete potentiation of vincristine cytotoxicity comparable to that achieved by the addition of prednisolone was observed when the latter drug was replaced by a variety of mineralocorticoids (aldosterone, desoxycorticosterone and fludrocortisone), glucocorticoids (hydrocortisone, dexamethasone), androgens (testosterone, methyltestosterone, androsterone, dehydroepiandrosterone, etiocholanolone), estrogens (estrone, 17‐βestradiol) and progestins (progesterone, pregnanediol). No potentiation of cytotoxicity was observed when nonsteroidal hormones (thyroxin, ACTH) were added to vincristine. It is concluded that a wide variety of compounds with the basic perhydrocyclopentano‐phenanthrene nucleus of the steroid molecule are capable of enhancing the cytotoxicity achieved with vincristine.
Paradoxical Effect of Domestic Animals on Asthma and Allergic Sensitization
Authors: Thomas A. E. Platts-Mills
Journal: JAMA (2002)

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