tbuckley/cabot-search huggingface dataset:
HHV-6 reactivation and its effect on delirium and cognitive functioning in hematopoietic cell transplantation recipients
Authors: Danielle M. Zerr, Jesse R. Fann, David Breiger, Michael Boeckh, Amanda L. Adler, Hu Xie, Colleen Delaney, Meei-Li Huang, Lawrence Corey, Wendy M. Leisenring
Journal: Blood (2011)
Aortic blood velocity measurement in healthy adults using a simple ultrasound technique
Authors: D H R MOWAT, N E HAITES, J M RAWLES
Journal: Cardiovascular Research (1983)

Journal Article Aortic blood velocity measurement in healthy adults using a simple ultrasound technique Get access D H R MOWAT, D H R MOWAT From the Department of Medicine, University of Aberdeen, Foresterhill, Aberdeen AB9 2ZD Search for other works by this author on: Oxford Academic PubMed Google Scholar N E HAITES, N E HAITES From the Department of Medicine, University of Aberdeen, Foresterhill, Aberdeen AB9 2ZD Search for other works by this author on: Oxford Academic PubMed Google Scholar J M RAWLES J M RAWLES * From the Department of Medicine, University of Aberdeen, Foresterhill, Aberdeen AB9 2ZD *Correspondence to: Dr J M Rawles Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 17, Issue 2, February 1983, Pages 75–80, https://doi.org/10.1093/cvr/17.2.75 Published: 01 February 1983
Abstract 2209: Downregulation of LKB1 in high-grade endometrial carcinoma
Authors: Ngai Na Chloe Co, David A. Iglesias, Rosemarie Schmandt, Karen H. Lu
Journal: Cancer Research (2011)

Abstract Objective: LKB1/STK11 encodes a serine/threonine kinase that regulates cell polarity, proliferation and energy metabolism via the AMPK signaling pathway. Germline mutations of LKB1 are responsible for Peutz-Jeghers syndrome, which is characterized by hamartomatous polyps and increased incidence of several cancers. It has been demonstrated that LKB1 null mice develop invasive endometrial cancer. Our lab has previously shown that 5 of 26 (19%) of human endometrial cancers exhibited loss of LKB1 protein by Western blot analysis. The purpose of this study was to examine the expression of LKB1 in a larger set of endometrial cancers and to determine if mutations in LKB1 occur in these tumors. Methods: LKB1 protein levels were evaluated in 20 normal endometrial tissues, 17 Grade 1, 24 Grade 2, and 28 Grade 3 endometrioid endometrial adenocarcinomas by immunohistochemical staining. Laser-capture microdissection (LCM) was used to isolate RNA from 22 Grade 1, 21 Grade 2 and 23 Grade 3 fresh frozen endometrioid endometrial tissues; and LKB1 mRNA expression levels in microdissected tumor samples were quantified by TaqMan quantitative PCR. Direct genomic DNA sequencing of LKB1 coding exons were performed on 20 microdissected high-grade tumors. Results: While no significant difference in LKB1 expression was observed between normal endometrium, Grade 1 and 2 endometrial tumors, LKB1 staining was significantly lower in Grade 3 tumors when compared with normal endometrium (P&amp;lt;0.0001), Grade 1 (P&amp;lt;0.0001) and Grade 2 (P=0.016) tumors. Downregulation of LKB1 mRNA level was also demonstrated in microdissected Grade 3 endometrial tumor samples. Direct genomic DNA sequencing of LKB1 coding exons revealed a single amino acid change (L201Q) in only 1 of 20 Grade 3 endometrial tumors, suggesting that DNA mutation is not the major mechanism leading to the loss of LKB1. Conclusion: Our findings of decreased expression of LKB1 in high-grade endometrial cancers supports the hypothesis that loss of LKB1 may contribute to the development of high-grade endometrioid endometrial cancer. We are currently evaluating the mechanisms by which LKB1 levels are regulated in endometrial cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2209. doi:10.1158/1538-7445.AM2011-2209
CHILD HYGIENE AND THE PRIVATE PHYSICIAN
Authors: BORDEN S. VEEDER
Journal: JAMA (1922)

strated change in the lesion; the amount of disability, and the presence of complications such as hemorrhage, perforation and stenosis.But, in addition to all these considerations, in reaching a decision as to a plan of treatment, we must give due regard to the life expec¬ tancy in the individual patient, and the economic neces¬ sity for absolute rather than temporary symptomatic cure, which is the frequent limit of medical therapy.
Changes to NHS tariff will put lives at risk, warn mental health bodies
Authors: M. Limb
Journal: BMJ (2014)

Six mental health organisations have urged the UK government to reconsider changes to the NHS tariff that they say will put “lives at risk.”

NHS England and Monitor have said that they would impose smaller cuts in the tariff for acute care trusts than for other types of trust for 2014-15 to reflect the extra costs that hospitals will incur to implement recommendations on safety, including recruiting more staff, made by Robert Francis QC after his inquiry into failings …
Cause-Specific Mortality Among Physicians With Differing Life-styles
Authors: Daniel Ullmann, Roland L. Phillipst, W. Lawrence Beeson, Houston G. Dewey, Burton N. Brin, Jan W. Kuzma, Chacko P. Mathews, Albert E. Hirst
Journal: JAMA (1991)

We compare the mortality experience of medical school graduates from Loma Linda University (LLU [n = 4342]) and the University of Southern California (USC [n = 2832]) with each other and with that of contemporaneous, white, American men. When compared with US white men from the general population, both USC and LLU graduates had below expected deaths for all causes (USC, standardized mortality ratio [SMR] = 76; LLU, SMR = 56), although deaths due to cerebrovascular disease, airplane accidents, and suicides were elevated for USC (SMRs = 132, 360, and 218, respectively). The LLU graduates had a risk similar to that of the USC graduates for fatal cancer, with a mortality ratio (MR) of 0.92 (95% confidence interval, 0.67 to 1.26); but half the risk of fatal atherosclerotic disease, with MRs of 0.58 (0.46 to 0.73) and 0.66 (0.43 to 0.99) for coronary and cerebrovascular disease, respectively; and three times the risk of fatal airplane accidents. The overall mortality rate of LLU physicians was only 75% as high as that of the USC physicians and only 56% as high as that of the US male population at large. We attribute this reduced mortality mainly to the low cardiovascular mortality rates, which may be accounted for by the life-style of the substantial proportion of Seventh-day Adventists among LLU graduates.
Cell-surface Accumulation of Flock House Virus-derived Peptide Leads to Efficient Internalization via Macropinocytosis
Authors: Ikuhiko Nakase, Hisaaki Hirose, Gen Tanaka, Akiko Tadokoro, Sachiko Kobayashi, Toshihide Takeuchi, Shiroh Futaki
Journal: Molecular Therapy (2009)

Arginine-rich cell-penetrating peptides (CPPs), including human immunodeficiency virus type 1 (HIV-1) Tat (48-60) and oligoarginines, have been applied as carriers for delivery of cargo molecules, because of their capacity to internalize into cells and penetrate biological membranes. Despite the fact that they have been extensively studied, the factors required for the efficient internalization of CPPs are still unclear. In this report, we evaluated the internalization efficiencies of seven CPPs derived from DNA/RNA-binding peptides, and discovered that a peptide derived from the flock house virus (FHV) coat protein was internalized most efficiently into Chinese hamster ovary (CHO-K1), HeLa, and Jurkat cells. Comparison of the factors facilitating the internalization with those of the Tat peptide revealed that the FHV peptide induces macropinocytosis much more efficiently than the Tat peptide, which leads to its high cellular uptake efficiency. Additionally, the strong adsorption of the FHV peptide on cell membranes via glycosaminoglycans (GAGs) was shown to be a key factor for induction of macropinocytosis, and these steps were successfully monitored by live imaging of the peptide internalization into cells in relation to the actin organization. The remarkable methods of FHV peptide internalization thus highlighted the critical factors for internalizations of the arginine-rich CPPs.
Continuing Medical Education and the American Medical Association
Authors: William R. Barclay
Journal: JAMA (1978)

In addition to the regular issue of JAMA appearing Sept 8, 1978, the American Medical Association is publishing a special continuing education number ofThe Journal. This special issue lists most of the continuing education courses available to physicians in the forthcoming year, with details of subject, time, place, cost, and credit hours so that physicians can more effectively plan to meet their own needs and preferences.  Continuing physician education is a number one priority for the AMA, and its Board of Trustees has allocated a substantial part of the AMA's resources to meet the needs of this high-priority area. The special continuing education number of JAMA is only one of many projects planned or in progress. The AMA scientific journals make up a large part of the effort to keep physicians informed on new developments in medicine and provide the most convenient form of continuing education, for they can
1012 TELBIVUDINE-INDUCED HBEAG SEROCONVERSION IN CHRONIC HEPATITIS B (CHB) IS DURABLE DURING 2 YEARS OFF-TREATMENT FOLLOW-UP
Authors: Y.-F. Liaw, K. Wursthorn, S. Thongsawat, X.-Q. Zhou, S.G. Hwang, A. Chutaputti, E.K. Teo, E.J. Gane, M. Jung, H. Wedemeyer, C. Avila
Journal: Journal of Hepatology (2010)
NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease
Authors: Thomas L. Nickolas, Catherine S. Forster, Meghan E. Sise, Nicholas Barasch, David Solá-Del Valle, Melanie Viltard, Charles Buchen, Shlomo Kupferman, Maria Luisa Carnevali, Michael Bennett, Silvia Mattei, Achiropita Bovino, Lucia Argentiero, Andrea Magnano, Prasad Devarajan, Kiyoshi Mori, Hediye Erdjument-Bromage, Paul Tempst, Landino Allegri, Jonathan Barasch
Journal: Kidney International (2012)
Electrocerebral Accompaniments of Syncope Associated with Malignant Ventricular Arrhythmias
Authors: MICHAEL J. AMINOFF
Journal: Annals of Internal Medicine (1988)

Study Objective: To examine the electrocerebral and clinical accompaniments of syncope associated with malignant ventricular cardiac arrhythmias. Design: Survey of clinical and electroencephalographic changes during induced cardiac dysrhythmia. Setting: Clinical electrophysiology laboratory of a university medical center. Patients: Fourteen patients with automatic cardioverter defibrillators due to previous cardiac arrest or life-threatening cardiac arrhythmia. Intervention: Deliberate induction of cardiac dysrhythmia for routine, postoperative testing of the automatic implantable cardioverter defibrillator. Continuous electrocardiographic, electroencephalographic, and video recording. Measurements and Main Results: Twenty-two episodes of ventricular tachycardia or fibrillation, lasting 15 to 126 seconds, were induced with definite loss of consciousness in 15 instances and probable loss in 2. In 10 episodes, there were motor accompaniments to the unconsciousness characterized by tonic activity or irregular muscle twitching. On regaining consciousness, patients were usually obtunded or confused for up to 30 seconds, depending on duration of induced cardiac dysrhythmia and unconsciousness. Electroencephalographic changes were variable. Background slowing was usually followed by relative loss of electrocerebral activity. In 2 patients, attenuation of background electrocerebral activity followed little or no change in background rhythms. In 5 episodes, electroencephalograms showed no change before loss of consciousness, but slowed thereafter in 4. Conclusions: Conspicuous motor activity may accompany syncope due to malignant ventricular arrhythmia and complicate the clinical distinction of syncope from seizures. Postsyncopal confusion generally lasts for less than 30 seconds. The electroencephalographic accompaniments of acute cerebral anoxia leading to syncope, and of the motor accompaniments of syncope, are more variable than previously appreciated, but electrographic seizure activity does not occur.
Corticosteroids for Pseudomembranous Colitis
Authors: H. A. Danemann
Journal: JAMA (1975)

<h3>To the Editor.—</h3> I am writing regarding the article by Drs Burbige and Milligan entitled "Pseudomembranous Colitis: Association With Antibiotics and Therapy with Cholestyramine" (231:1157, 1975). If the use of a drug such as cholestyramine resin proves to be effective in the treatment of inflammatory bowel disease, we are indeed fortunate. The purpose of this letter is to comment on a sentence in the body of the article: "Corticosteroids have been employed in some severely affected individuals but have not been effective." It seems to me that this statement is inaccurate and misleading. There are numerous articles citing the use of corticosteroids in this condition with beneficial results. This has been our experience in this community, where we have seen an unusual number of such cases. I would appreciate the authors reconsidering their statement in view of the fact that it might mislead a physician into hesitating to use a
Is screening for early lung cancer worthwhile?
Authors: Beverly Merz
Journal: JAMA (1983)

Screening an at-risk population for early-stage lung cancer—a practice that has been declared ineffective by the American Cancer Society (ACS) because studies have not shown that it lowers mortality rates—nonetheless received emphatic support at the recent annual meeting of the Radiological Society of North America in Chicago. In defense of radiological screening, John R. Muhm, MD, director of diagnostic radiology at the Mayo Clinic, Rochester, Minn, cited results of the ongoing Mayo Lung Project, and Robert T. Heelan, MD, assistant attending radiologist, Memorial Sloan-Kettering Cancer Center, New York City, presented data from the National Lung Program (NLP). These programs, as well as a third conducted at Johns Hopkins University in Baltimore, are sponsored by the National Cancer Institute (NCI), Bethesda, Md. Both Muhm and Heelan emphasized that the value of radiography in detecting early-stage disease is limited to certain forms of the disease—adenocarcinoma, squamous cell carcinoma, and large-cell carcinoma—that are
Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer
Authors: Steven A. Rosenberg, Michael T. Lotze, Linda M. Muul, Susan Leitman, Alfred E. Chang, Stephen E. Ettinghausen, Yvedt L. Matory, John M. Skibber, Eitan Shiloni, John T. Vetto, Claudia A. Seipp, Colleen Simpson, Cheryl M. Reichert
Journal: New England Journal of Medicine (1985)

Abstract We describe here the preliminary results of the systemic administration of autologous lymphokine-activated killer (LAK) cells and the recombinant-derived lymphokine interleukin-2 to patients with advanced cancer. This regimen was based on animal models in which the systemic administration of LAK cells plus interleukin-2 mediated the regression of established pulmonary and hepatic metastases from a variety of murine tumors in several strains of mice. We treated 25 patients with metastatic cancer in whom standard therapy had failed. Patients received both 1.8 to 18.4×1010 autologous LAK cells, generated from lymphocytes obtained through multiple leukaphereses, and up to 90 doses of interleukin-2. Objective regression of cancer (more than 50 per cent of volume) was observed in 11 of the 25 patients: complete tumor regression occurred in one patient with metastatic melanoma and has been sustained for up to 10 months after therapy, and partial responses occurred in nine patients with pulmonary or hepatic metastases from melanoma, colon cancer, or renal-cell cancer and in one patient with a primary unresectable lung adenocarcinoma. Severe fluid retention was the major side effect of therapy, although all side effects resolved after interleukin-2 administration was stopped. Further development of this approach and additional patient follow-up are required before conclusions about its therapeutic value can be drawn.
Coagulopathy in amyloidosis: Combined deficiency of factors IX and X
Authors: Richard A. McPherson, John W. Onstad, Richard J. Ugoretz, Paul L. Wolf
Journal: American Journal of Hematology (1977)

Abstract Combined severe deficiencies of blood clotting factors IX and X were observed in 2 patients who suffered from systemic amyloidosis. This unique deficiency state was marked by refractoriness to Vitamin K as well as to transfusion therapy. Increased antithrombin activity was present in both individuals and corresponded in time to the emergence of a monoclonal IgG kappa light chain paraprotein in 1. Both patients demonstrated profound bleeding disorders. It is hypothesized that the Vitamin K dependent factors have special affinity for amyloid deposits due to an unusual amino acid (γ‐carboxyglutamic acid) present in these factors.
Dying is Worked to Death
Authors: Samuel Vaisrub
Journal: JAMA (1974)

We are now witnessing an extraordinary influx of essays, editorials, even books and specialized journals, on the subject of death and dying. The tide, no longer limited to the medical literature, overflows into lay publications and other communication media. Death and dying have been always with us. Why then the current preoccupation? Even if we allow for some ethical and legal problems created by recent technological advances in life support—problems that are sufficiently new to merit comment—how do we account for the extensive writing on the "why's" and the "how's" of looking after a dying patient and his family? Has there been a recent change in attitudes toward death? Some authorities claim that this is indeed the case. They contend that because the belief in afterlife is no longer as firm as it was in the past, death assumes the terrifying nondimension of nothingness. "Tell me your secret," pleads the
Severe chronic urticaria is associated with elevated plasma levels of D‐dimer
Authors: R. Asero, A. Tedeschi, P. Riboldi, S. Griffini, E. Bonanni, M. Cugno
Journal: Allergy (2007)

Patients with chronic urticaria (CU) frequently show signs of thrombin generation as a result of the activation of the extrinsic pathway of coagulation and signs of fibrinolysis as shown by slightly increased mean D-dimer plasma levels. Here, we studied patients with severe CU to see whether the activation of coagulation and fibrinolysis parallels the severity of the disease.Eight consecutive patients with severe exacerbations of CU and 13 with slight CU were studied. Plasma prothrombin fragment F(1+2) as well as D-dimer were measured by ELISA. Serum histamine-releasing activity was assessed by basophil histamine release assay. Seventy-four normal subjects were used as controls.In patients with severe CU, median levels of both D-dimer (11.20 nmol/l) and F(1+2) (592 pmol/l) largely exceeded those found in patients with slight CU [D-dimer: 2.66 nmol/l (P = 0.001) and F(1+2): 228 pmol/l (P = 0.003)] and in normal subjects [D-dimer: 1.41 nmol/l (P = 0.0001) and F(1+2): 159 pmol/l (P = 0.0001)]. Sera from 25% of patients with severe CU and 31% of those with slight CU, but from none of normal subjects, showed in vitro histamine-releasing activity. D-dimer and F(1+2) levels were significantly correlated each other (r = 0.64, P = 0.002) and with CU severity score (r = 0.80-0.90, P = 0.0001), but no correlation was observed between serum histamine-releasing activity and coagulation parameters or severity score.Severe exacerbations of CU are associated with a strong activation of coagulation cascade and fibrinolysis. Whether this activation is the cause of CU or acts as an amplification system is still a matter of debate.
Chimiothérapie versus prothèse oesophagienne comme traitement de première intention de la dysphagie maligne des cancers de l'œsophage inopérables
Authors: I Mabile, E Mitry, B Landi, S Reignier, F Prat, V Veuillez, A Lievre, C Lepere, G Lesur, C Cellier, P Rougier
Journal: Endoscopy (2008)

Introduction: Le but de notre étude était de décrire rétrospectivement deux stratégies de prise en charge de la dysphagie maligne des tumeurs inopérables de l'oesophage: chimiothérapie (CT) première ou prothèse œsophagienne (P) première associée ou non à un traitement anti-cancéreux ensuite.
Fasting protects liver from ischemic injury through Sirt1-mediated downregulation of circulating HMGB1 in mice
Authors: Andreas Rickenbacher, Jae Hwi Jang, Perparim Limani, Udo Ungethüm, Kuno Lehmann, Christian E. Oberkofler, Achim Weber, Rolf Graf, Bostjan Humar, Pierre-Alain Clavien
Journal: Journal of Hepatology (2014)
Prevention of Postoperative Deep Venous Thrombosis in Legs by Orally administered Hydroxychloroquine Sulphate
Authors: A. E. Carter, R. Eban
Journal: BMJ (1974)

Questionnaire surveys suggest physical activity levels in children are low, particularly among children from deprived areas. Using accelerometers, it was found that children from a deprived inner city school were active at recommended levels and had similar levels of activity to children in other studies from more affluent populations. However, this finding was dependent on the threshold used to define moderate activity.
Providing a continuum between medical school and foundation training
Authors: J. B. Cookson
Journal: BMJ (2014)

Dickson identifies several problems with the proposal to move the point of full registration to the end of the undergraduate course.1

Undergraduate schools will also encounter difficulties. Currently, their final examination measures what students can do as students. What they will do as doctors remains conjectural. If graduation leads to full registration, schools will need to ensure that final year students are …
Equivalence Lack in Digoxin Plasma Levels
Authors: John G. Wagner, Marianne Christensen, Ermelinda Sakmar, Donald Blair, James D. Yates, Park W. Willis, Allen J. Sedman, Roger G. Stoll
Journal: JAMA (1973)

In an eight-subject two-way crossover study, 0.5-mg oral doses of digoxin were administered as two 0.25-mg tablets made by two different manufacturers. Treatment "B" yielded average peak plasma levels and areas under the curves that were 59% and 55%, respectively, of those attained following treatment "A". Two of the eight subjects also received the same dose in 5% dextrose both orally and by constant rate intravenous infusion during a one-hour period. Average peaks were 4.19, 3.76, 1.46, and 0.70 ng/ml following the intravenous infusion, solution orally, treatment A (tablet) orally, and treatment B (tablet) orally, respectively. Relative areas under the curves were 100%, 80.2%, 56.7%, and 30.7% for the treatments in the same order.