tbuckley/cabot-search huggingface dataset:
False-Positive Tl-201 SPECT in a Case of Cerebral Tuberculoma
Authors: Daniela Di Giuda, Venanzio Valenza, Tommaso Tartaglione, Gaetano Squadrito, Carlo Focacci
Journal: Clinical Nuclear Medicine (2006)

Tl-201 brain SPECT is considered a useful imaging technique for preoperative grading of malignancy, distinguishing radionecrosis from recurrent tumor, and differentiating cerebral lymphoma from opportunistic infections in patients with AIDS. The authors describe the unexpected findings of Tl-201 SPECT in a case of intracranial tuberculoma. A 44-year-old-man with human immunodeficiency virus infection was hospitalized because of headache and cognitive deficit. Multiple brain lesions with contrast enhancement and mass effect were detected by magnetic resonance imaging in the deep frontal lobe (markedly on the left side), corpus callosum, left basal ganglia, and right parietal region. Toxoplasma serology was negative. The patient underwent Tl-201 brain SPECT; focal radiotracer uptake was found in left frontal lobe, corresponding to the region of MR-detected abnormalities. A high lesion-to-background uptake ratio was calculated (L/B: 3.38), suggesting an aggressive tumor such as primary cerebral lymphoma. Cerebrospinal fluid analysis by polymerase chain reaction failed to detect Epstein-Barr virus DNA. On the basis of histologic examination by stereotactic biopsy, a cerebral tuberculoma was finally diagnosed.
Razoxane in treatment of acute myeloid leukaemia
Authors: D Obeid, P. Cotter
Journal: BMJ (1978)

Juel-Jensen's syndrome ?) ?Perhaps this explains the lack of concern about the un- palatability of heavily chlorinated water.I still maintain that flavouring is "very well worth while" when trying to force fluids into an anorexic, nauseated, uncooperative, delirious, and dehydrated patient.May I also thank Dr D L Child and his colleagues (14 October, p 1086) for their suggestions, which I accept?A parenteral form of chloroquine should have been included and its omission was a transcription error on my part.Chloramphenicol is undoubtedly useful, though I am less sure of co-trimoxozole in patients who have taken Streptotriad prophylactically.Finally, I would prefer to prescribe Nystaform-HC (nystatin, iodochlorhydroxyquin, and hydrocortisone) to clotrimazole, since the former rapidly alleviates the common allergic component of candidiasis, but this is a quibble.
A New Penicillin (BRL 1241) Active Against Penicillin-resistant Staphylococci
Authors: R. Knox
Journal: BMJ (1960)

BRL 1241 consider the pain of injections is comparable.No other toxic effects were encountered.Blood and Jrine Levels.-These were assayed on patients who were being treated with BRL 1241 when- ever this was possible.In all cases assayed, blood levels showed a range of concentration between 18 and 21 ,ug./ml.at half an hour, 13 to 20 ug. at one hour, 5 to 9 ,ug.at two hours, and 1.5 to 2.7 jug. at three hours.By the fourth hour serum concentrations were invariably below 2 ,ug.Urinary assay showed that 75% of the dose administered in one day was excreted in the urine -for example, six injections of 1 g. were given in 24 hours and 4,372 mg. were excreted in the urine over the same period, which is 73 % of the injected dose.Knudsen and Rolinson (1960), in their studies of absorption and excretion, showed similar results. DiscussionThe real test of effectiveness of this drug is whether it failed to eradicate staphylococci in any instance or caused such severe side-effects that it had to be with- drawn.So far in our limited experience no case failed to respond to treatment.In Case 4, with staphylococcal infection of the lung, the organism was eliminated but the patient died of his underlying cor pulmonale.It was not thought that any antibiotic treatment would have made much difference to his cardiac condition.Stewart et al. ( 1960) report one patient (Case 14, aged 2) who relapsed after treatment of her multiple boils with BRL 1241.They report that staphylococcal infection was eradicated in all their other cases but was not necessarily extirpated from the anterior nares. Summary and ConclusionsA clinical trial of BRL 1241, a derivative of 6-amino- penicillanic acid, is reported.Thirteen cases of staphylococcal infection resistant to penicillin G and/or other antibiotics are recorded.No serious toxic effects were encountered.The drug was successful in eradicating staphylococci in all.The results reported suggest strongly that the drug is effective against the resistant staphylococcus.We are grateful for supplies of BRL 1241 to Beecham Research Laboratories Limited, whose registered trade name for this drug is "celbenin."Our thanks are due to the physicians and surgeons at Guy's Hospital who allowed us to treat their cases.
Enhanced production of glomerular extracellular matrix in a new mouse strain of high serum IgA ddY mice
Authors: Eri Muso, Haruyoshi Yoshida, Eiji Takeuchi, Masatomo Yashiro, Hiroyuki Matsushima, Atsushi Oyama, Katsuo Suyama, Takahide Kawamura, Tadashi Kamata, Shigeki Miyawaki, Shozo Izui, Shigetake Sasayama
Journal: Kidney International (1996)
New research on cannabis.
Authors: A M Campbell, J L Thomson, M J Williams
Journal: BMJ (1971)

suggest that from the standpoint of long- term forward planning it may be the correct one, and it is noteworthy that in my ex- perience visitors from other countries are usually full of admiration for the general standard of care offered to all psychiatric in- patients in Britain.You refer to the paper by Anthea M. Hailey2 based on the Camberwell Register.She states that the composition of the long- stay group which she studied is changing and that the group is being replaced in part by "a large number of psycho-geriatric patients."She adds: ". . .elderly patients contribute half the new long-stay build- up . .."Yet when Mrs. Hailey concludes by asking whether present trends of care are in the right direction you appear, in effect, to support the view that it is correct for increasing numbers of the elderly confused to be accommodated in mental hospitals.I would join issue with this implication.At another point in her paper Mrs. Hailey states that ". . .hospital policies differ and the constitution of a long-stay group at any one time depends both on this and on avail- ability of alternative services in the locality."This is indeed true and, for example, one cannot help but notice that in the general
Stress echocardiography in the detection of myocardial ischemia. Head-to-head comparison of exercise, dobutamine, and dipyridamole tests.
Authors: B D Beleslin, M Ostojic, J Stepanovic, A Djordjevic-Dikic, S Stojkovic, M Nedeljkovic, G Stankovic, Z Petrasinovic, L Gojkovic, Z Vasiljevic-Pokrajcic
Journal: Circulation (1994)

BACKGROUND Exercise and pharmacological stress echocardiography have emerged as convenient alternatives to myocardial scintigraphy. The objective of this study was to compare in the same patients the diagnostic values of exercise, dobutamine, and dipyridamole stress echocardiography tests for detection of myocardial ischemia. METHODS AND RESULTS We performed exercise (maximal treadmill Bruce protocol), dobutamine (up to 40 micrograms/kg per minute) and dipyridamole (up to 0.84 mg/kg over 10 minutes) stress echocardiography tests, in random sequence and on separate days, in 136 consecutive patients. All patients underwent coronary angiography. Significant coronary artery disease was defined by quantitative coronary angiography as a lesion with a diameter stenosis &gt; or = 50%. A stress echocardiogram was considered positive when new or worsening of preexisting wall motion abnormality was observed. Most of the patients (94%) were receiving the same antianginal medication for each stress test; 59 patients were receiving concomitant beta-blocker therapy. The prevalence of coronary artery disease was 87.5%, with 108 patients having one-vessel coronary artery disease. Peak heart rate and systolic blood pressure were higher with exercise than with dobutamine or dipyridamole (P &lt; .01). Sensitivity of exercise, dobutamine, and dipyridamole stress echocardiography was 88%, 82%, and 74% (dipyridamole versus exercise, P &lt; .01), respectively. Specificity was 82%, 77%, and 94%, respectively. The overall accuracy was 87%, 82%, and 77% (dipyridamole versus exercise, P &lt; .01), respectively. The accuracy of dipyridamole was higher (P = .02) in the group of patients not receiving beta-blockers (84%) than in the patients receiving beta-blocker therapy (66%), whereas the accuracy of exercise and dobutamine were only slightly higher in the patients not receiving beta-blockers. Significant side effects occurred in 3%, 11%, and 1% of patients during exercise, dobutamine, and dipyridamole tests, respectively. CONCLUSIONS Despite the different hemodynamic effects, exercise, dobutamine, and dipyridamole echocardiography have high overall diagnostic values. In this group of patients with a predominance of one-vessel coronary artery disease, the overall diagnostic accuracy of stress echocardiography tests was higher for exercise than for dobutamine or dipyridamole. Concomitant beta-blocker therapy significantly decreased the accuracy of the dipyridamole stress echocardiography test. Pharmacological stress testing (dipyridamole without beta-blockers) can therefore be used as an efficient option for detection of myocardial ischemia in patients who are unable or poorly motivated to exercise adequately.
Practical applications of the Quantimet 720* an image analysing computer, in the field of investigative dermatology
Authors: W. PICTON, H. DEVITT, M.A. FORGIE
Journal: British Journal of Dermatology (1976)

Image analysing computers can perform quantitative measurements of epidermal thickness, sebaceous gland volume, and labelling indices of epidermis easily, rapidly and automatically. All these parameters are extremely important in investigative dermatology and this paper describes how they are measured using the Quantimet 720.
Characteristics of Objects That Cause Choking in Children
Authors: Frank L. Rimell
Journal: JAMA (1995)

To characterize the types, shapes, and sizes of objects causing choking or asphyxiation in children and to compare these characteristics to current standards.To evaluate morbidity, retrospective 5-year medical record survey; to evaluate mortality, data reanalysis.Pediatric hospital and consumer product testing laboratory.All children (n = 449) who underwent endoscopy for foreign body aspiration or ingestion at Children's Hospital of Pittsburgh (Pa) between 1989 and 1993 and children (n = 449) whose deaths due to choking on man-made objects were recorded by the Consumer Product Safety Commission (CPSC) between 1972 and 1992.Objects removed from children's aerodigestive tracts were characterized by location, procedure for removal, and type. Objects causing death were characterized by type, shape, and consistency. Three-dimensional objects that had caused asphyxiation were analyzed by computer-simulated models.Of the 165 children treated by endoscopy, 69% were 3 years of age or younger. Foreign bodies most often ingested or aspirated were food (in 36 children) and coins (in 60 children). Of 449 children whose deaths after aspirating foreign bodies were reported to the CPSC, 65% were younger than 3 years. Balloons caused 29% of deaths overall. Conforming objects such as balloons caused a significantly (P < .001) higher proportion of deaths in those aged 3 years or older (60%) vs those younger than 3 years (33%). Of the 101 objects causing deaths that we could analyze, 14 met current standards for use by children of any age.Balloons pose a high risk of asphyxiation to children of any age. Changes in regulations regarding products intended for children's use might have prevented up to 14 (14%) of 101 deaths in this study.
COCCIDIOIDAL GRANULOMA.REVIEW OF THE EIGHTEEN CASES AND REPORTS OF CASES FIFTEEN AND SIXTEEN.
Authors: PHILIP KING BROWN
Journal: JAMA (1907)

The recognition, within a few years, of a comparatively large number of extremely fatal cases of a hitherto unknown disease, seems of sufficient interest to warrant me in presenting the last of these cases, together with a history of the findings in the other cases, the localities from which they came and a statement of certain experimental data in regard to the possible modes of infection. A review by Ricketts<sup>1</sup>on oidiomycosis gives an interesting statement of the pathogenicity of the moulds that belong to this class and a discussion of their relation to each other. He dwells at great length on the cases of blastomycetic dermatitis, occurring in the middle West, reviews fourteen old cases of this disorder and reports several more which he has collected. He also reviews the cases of coccidioidal granuloma and considers that there is a close relation between it and blastomycetic dermatitis and
TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess
Authors: Leila Idrissova, Harmeet Malhi, Nathan W. Werneburg, Nathan K. LeBrasseur, Steven F. Bronk, Christian Fingas, Tamar Tchkonia, Tamar Pirtskhalava, Thomas A. White, Michael B. Stout, Petra Hirsova, Anuradha Krishnan, Christian Liedtke, Christian Trautwein, Niklas Finnberg, Wafik S. El-Deiry, James L. Kirkland, Gregory J. Gores
Journal: Journal of Hepatology (2014)
Influenza vaccine-induced interstitial lung disease
Authors: Satoshi Watanabe, Yuko Waseda, Hazuki Takato, Kanako Inuzuka, Nobuyuki Katayama, Kazuo Kasahara, Masaki Fujimura
Journal: European Respiratory Journal (2013)

Influenza vaccine-induced interstitial lung diseaseTo the Editor:Influenza is a serious disease that can spread around the world in seasonal epidemics, resulting in the deaths of an estimated 250,000 to 500,000 people every year [1].Vaccination is the most effective method for preventing secondary complications and the risk of influenza-related hospitalisation and death.The influenza vaccine is safe in general, and the most common side-effects, such as injection-site reaction, pain, fever, myalgia and headache, are not important clinically [2].However, a few case reports of interstitial lung disease (ILD) caused by influenza vaccine have been published.We report a case of influenza vaccine-induced ILD with a review of the literature.
The anticancer efficacy of paclitaxel liposomes modified with mitochondrial targeting conjugate in resistant lung cancer
Authors: Jia Zhou, Wei-Yu Zhao, Xu Ma, Rui-Jun Ju, Xiu-Ying Li, Nan Li, Meng-Ge Sun, Ji-Feng Shi, Cheng-Xiang Zhang, Wan-Liang Lu
Journal: Biomaterials (2013)
Male Sexual Function and Its Disorders: Physiology, Pathophysiology, Clinical Investigation, and Treatment
Authors: Fouad R. Kandeel, Vivien K. T. Koussa, Ronald S. Swerdloff
Journal: Endocrine Reviews (2001)

This review is designed to help the reproductive endocrinologist integrate his or her professional activity with those of other disciplines including urology, radiology, neurology, and psychology in order to successfully manage all of the inseparable aspects of male sexual and reproductive functioning. Significant advances in the field of male sexual physiology and pathophysiology and new methods of investigation and treatment of male sexual disorders are outlined. The review synthesizes available data on the following: norms of sexual organs, aging and sexuality, role of central and peripheral neurochemicals in each stage of the sexual cycle, role of corporeal smooth muscles in the hemodynamic control of erection and detumescence, influence of psychological factors, drugs, and disease on all aspects of sexual functioning, and use of nocturnal penile tumescence monitoring, imaging investigations, and neurophysiologic studies in the diagnostic workup of males with sexual dysfunction. Clinical algorithms are presented where appropriate. Extensive discussions on newly developed strategies in psychological and behavioral counseling, drug therapy, tissue engineering, nonsurgical devices, and surgical treatments for all forms of sexual disorders are also provided. Lastly, the effect of sexual dysfunction and its treatment on quality of life in affected men is addressed, along with recommendations for future research endeavors.
Science and Immortality
Authors: Marjorie C. Meehan
Journal: JAMA (1977)

<h3>In After Days: Thoughts on the Future Life,</h3> by W. D. Howells et al (reprint of 1910 ed), 233 pp, with illus, $18, New York, Arno Press, 1977. <h3>Before the Great Silence,</h3> by Maurice Maeterlinck (Bernard Miall, trans, reprint of 1936 ed), 200 pp, $14, New York, Arno Press, 1977. Although much has been written recently about dying, not so much has been said about immortality. However, the recently issued Arno series of reprints,<i>The Literature of Death and Dying</i>, includes several works on this topic. Physicians may be especially interested in the 1904 lecture<i>Science and Immortality</i>, by Osler. Osler did not choose this topic, and rather reluctantly consented to deliver "the Ingersoll lecture on the immortality of man." In this graceful talk, rich in classical and poetic allusions and quotations, he discussed various attitudes toward the question of immortality and the difficulty of reconciling faith and reason. He
People buying their own social care need more support, watchdog warns
Authors: C. White
Journal: BMJ (2011)

UK taxpayers could be faced with a bill of £1bn a year by 2035—double what it is now—for rescuing people who fund their own social care when they run out of money, concludes a report by the National Audit Office, unless more stringent oversight arrangements are put in place.

The public spending watchdog’s report, which looks at choice and competition in care services for people who use private funds (self funders) or local government funds (personal budget holders) to buy care services of their own choosing, says that the market is beset by variable levels of support and information and a lack of formal oversight.

Unless these shortcomings are dealt with, it warns, the opening up of the market won’t represent value for money in …
ECTOPIC GESTATION—A REPORT OF TWO CASES.
Authors: J. E. ALLABEN
Journal: JAMA (1907)

<h3>Case 1.</h3> —Tubal pregnancy; rupture within the broad ligament. Case mistaken for acute perforating appendicitis. Operation, hysterectomy, recovery. <h3>History.</h3> —On Aug. 21, 1906, I was called in haste to see Mrs. M. L., widow, aged 28. I found her in bed in much distress and obtained the following history: While walking downtown about 10 a. m. that morning she was taken suddenly ill with a severe pain in the lower abdomen, most marked on the right side. She became very faint and fell to her knees and was unable to rise to her feet for some minutes. She continued her journey downtown, but on account of pain and weakness was obliged frequently to sit down. After doing her errand, she took a car to her home; the car left her within four blocks of her house. One-half hour was consumed in traversing this distance owing to pain and faintness. She
Abstract 1376: Antiangiogenic properties of the peptide CIGB-300
Authors: Hernán G. Farina, Fernando Benavent Acero, Yasser Perera, Arielis Rodríguez, Silvio Perea, Boris Acevedo Castro, Roberto Gomez, Daniel F. Alonso, Daniel E. Gomez
Journal: Cancer Research (2010)

Abstract CK2 is a highly conserved protein serine/threonine kinase that is ubiquitously distributed in eukaryotes, constitutively active and has been implicated in multiple cellular functions, as well as in tumorigenesis and transformation. Elevated CK2 activity has been associated with the malignant transformation of several tissues and is associated with aggressive tumor behavior. Previously, we have described a peptide CIGB-300 (also named P15-Tat) targeting the acidic phophorylation domain of the CK2 substrates. Different groups around the world have tried to manipulate this biochemical event by targeting the ATP-binding site of CK2 or its gene transcription using antisense oligonucleotides. Otherwise, CIGB-300 peptide was developed following the innovative approach of targeting the phosphoaceptor site on the CK2 substrates rather than the enzyme per se. We demonstrated that CIGB-300 induced apoptosis on tumor cells and tumor regression when injected directly into solid tumors or by systemic administration in mice. In this work we have evaluated the CIGB-300 peptide on the angiogenic process, both in vitro and in vivo. We have focused in the exploration of CIGB-300 properties to inhibit proliferation, tube formation and RNA pattern expression on endothelial cells (HUVEC). Likewise we used the chicken chorioallatoic membrane (CAM) assay as a model in vivo to asses the CIGB-300 activity on angiogenesis. Others authors have studied the role of different CK2 inhibitors on angiogenesis finding that CK2 is involved in endothelial cell proliferation, survival, migration and tube formation. Intraperitoneally administered CK2 inhibitors significantly reduced preretinal neovascularization in a mouse model of proliferative retinopathy. Solid tumors require the growth of new blood vessels (angiogenesis) to grow. Tumor angiogenesis utilizes at least some of the angiogenic signalling pathways that are required during vascular development. Tumor angiogenesis has become an important target for antitumor therapy, with most current therapies aimed at blocking the VEGF pathway. However, not all tumors are responsive to VEGF blockers, and some of them that are responsive initially may become resistant during the course of treatment, thus there is a need to explore other angiogenesis signalling pathways. In this paper we have examined the antiangiogenic properties of CIGB-300 peptide in vitro and in vivo. The data suggests that CK2 is involved in angiogenic processes and CIGB-300 could act as promising antiangiogenic inhibitor. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1376.
Reversible Edwards Sapien XT Dysfunction Due to Prosthesis Thrombosis Presenting as Early Structural Deterioration
Authors: Azeem Latib, David Messika-Zeitoun, Francesco Maisano, Dominique Himbert, Eustachio Agricola, Eric Brochet, Ottavio Alfieri, Antonio Colombo, Alec Vahanian
Journal: Journal of the American College of Cardiology (2012)
Art, history, and rheumatism: the case of Erasmus of Rotterdam 1466-1536 suffering from pustulotic arthro-osteitis.
Authors: J Dequeker
Journal: Annals of the Rheumatic Diseases (1991)

Pustulotic arthro-osteitis probably associated with retroperitoneal fibrosis has been diagnosed in Erasmus of Rotterdam, based on paintings of Quentin Massys (1517) and Hans Holbein the younger (1523), historical letters of Erasmus, and postmortem examination of the skeleton. This case report is a description of the earliest known case of pustulotic arthro-osteitis, a syndrome reported for the first time in 1967 and seen more commonly in Japan than in Europe. Works of art of many different kinds may provide an important source of evidence of disease and contribute to a better understanding of the natural history of a disease.