tbuckley/cabot-search huggingface dataset:
Recent advances on the role of tumor exosomes in immunosuppression and disease progression
Authors: Paola Filipazzi, Maja Bürdek, Antonello Villa, Licia Rivoltini, Veronica Huber
Journal: Seminars in Cancer Biology (2012)

Exosomes are endosomal-derived nanovesicles released by most cells types, including tumor cells, and principally involved in intercellular communication in physiology and disease. Tumor exosomes are gaining increasing interest in medicine and oncology as efficient tools for the delivery of defined signals. Representing the acellular replicas of tumor cells, they contain a great variety of bioactive molecules, such as proteins, RNA, miRNA and DNA. Their great ability to recirculate in body fluids and their structure allow them to transport their cargo to distant targets. Major studies have shown that tumor exosomes convey information not only between tumor cells but also to other cell types, including different immune cell components. There is increasing evidence that these nanovesicles may contribute to cancer progression by influencing different immune cell types, likely blunting specific T cell immunity and skewing innate immune cells toward a pro-tumorigenic phenotype. Because of this function and the additional property to deliver molecular signals modulating neoangiogenesis and stroma remodeling, tumor exosomes are believed to play a role in tumor progression by favoring metastatic niche onset. This review outlines the recent knowledge on immune suppressive mechanisms mediated by tumor exosomes. We will discuss our view on the role of these nanovesicular structures in cancer progression and how their presence could interfere with cancer therapy.
Hydronephrosis or Neonatal Urinary Ascites
Authors: Benedict R. Harrow
Journal: JAMA (1965)

<h3>To the Editor:—</h3> The article "Perirenal Contrast Medium" (<b>193</b>:1121, 1965), in which Dockray describes a new roentgenographic sign of neonatal urinary ascites, is of interest. The distinctive roentgenographic halo sign is explained by transudation or extravasation of opacified urine from the kidney into the retroperitoneal space and is described as a perirenal halo. It would appear to us from the roentgenogram that the peripheral nephrogram effect of hydronephrosis as described by Allen et al (<i>Radiology</i><b>80</b>:203, 1963) is the responsible mecha[ill]m. According to these authors, the nephrogram represents compressed functioning renal parenchyma. Variations of this principle which grossly dilated calyces formed "the crescent sign" were described by Dunbar et al in 1962. LeVine et al (<i>Radiology</i><b>81</b>:971, 1963) suggested that the crescent sign histologically appeared to be due to retention of contrast material in dilated peripherally displaced renal tubules. The halo sign as described by Dockray
Surgical treatment of endomyocardial fibrosis: A new approach
Authors: Sergio Almeida de Oliveira, Antonio Carlos Pereira Barreto, Charles Mady, Luiz Alberto de Oliveira Dallan, Protasio Lemos da Luz, Adib Domingos Jatene, Fulvio Pileggi
Journal: Journal of the American College of Cardiology (1990)
FREE FORMALDEHYDE IN TEXTILES IN RELATION TO FORMALIN CONTACT SENSITIVITY.
Authors: L. BERRENS, E. YOUNG, L. H. JANSEN
Journal: British Journal of Dermatology (1964)

Journal Article FREE FORMALDEHYDE IN TEXTILES IN RELATION TO FORMALIN CONTACT SENSITIVITY. Get access L. BERRENS, L. BERRENS Dermatological Department. Academic Hospital, State University, Catharijnesingel 101, Utrecht, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar E. YOUNG, E. YOUNG Dermatological Department. Academic Hospital, State University, Catharijnesingel 101, Utrecht, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar L. H. JANSEN L. H. JANSEN Dermatological Department. Academic Hospital, State University, Catharijnesingel 101, Utrecht, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 76, Issue 3, 1 March 1964, Pages 110–115, https://doi.org/10.1111/j.1365-2133.1964.tb14488.x Published: 01 March 1964
Effect of cholestyramine on bile acid metabolism in normal man
Authors: J. T. Garbutt, T. J. Kenney
Journal: Journal of Clinical Investigation (1972)

The effect of cholestyramine administration on the enterohepatic circulation of bile acids was studied in eight normal volunteers. In six subjects the metabolism of sodium taurocholate-(14)C was determined after its intravenous injection before and during the 6th wk of cholestyramine administration, 16 g/day. In two subjects, the metabolism of cholic acid-(14)C was observed before and during the 2nd wk of cholestyramine, 16 g/day. Bile acid sequestration resulted in a more rapid disappearance of the injected primary bile acid and its metabolic products. The composition of fasting bile acids was promptly altered by cholestyramine to predominantly glycine-conjugated trihydroxy bile acid. In four subjects, unconjugated bile acid-(14)C was administered during cholestyramine administration; the relative proportion of glycine-conjugated bile acid-(14)C before enterohepatic circulation was similar to the relative proportion of unlabeled glycine-conjugated bile acid present in duodenal contents after an overnight fast, indicating that a hepatic mechanism was responsible for the elevated ratios of glycine- to taurine-conjugated bile acid (G: T ratios) observed. The relative proportions of both dihydroxy bile acids, chenodeoxycholic and deoxycholic, were significantly reduced. Steatorrhea did not occur, and the total bile acid pool size determined after an overnight fast was unaltered by cholestyramine. These findings suggest that in normal man bile acid sequestered from the enterohepatic circulation by cholestyramine is replaced by an increase in hepatic synthesis primarily via the pathway leading to production of glycocholic acid.
Diet and Cancer
Authors: Walter C. Willett
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Removable fully covered self-expandable metal stents in the treatment of common bile duct strictures due to chronic pancreatitis: A case series
Authors: D. Cahen, E. Rauws, D. Gouma, P. Fockens, M. Bruno
Journal: Endoscopy (2008)

The aim of this study was to test the removability of fully covered self-expandable metal stents (FCSEMS) in patients with a benign common bile duct (CBD) stricture. A FCSEMS was inserted in six patients with a CBD stricture due to chronic pancreatitis who were considered to be unfit for surgery, and stent removal was attempted after predefined intervals of 4 and 6 months. FCSEMS were successfully placed in all patients (100 % placement success) and stent extraction was accomplished in four patients (66 % removal rate), all of whom achieved stricture resolution (66 % resolution rate). In one patient a recurrent stenosis developed after 6 months (recurrence rate 25 %). Proximal stent migration occurred in two patients. In conclusion, FCSEMS removal was possible in the majority of patients and results regarding stricture dilation were promising. Nevertheless, before FCSEMS can become an acceptable treatment option for benign CBD strictures, innovative stent design modifications are necessary and removability must be ascertained.
Multiple-puncture tuberculin testing.
Authors: A J Johnson, J A Lunn
Journal: BMJ (1979)

Multiple-puncture tuberculin testing A J Johnson, mrcp, and J A Lunn, ffcm; J T Hart, frcgp. 1624 Injuries to boys who scramble R H Jackson, frcp, and A W Craft, md_ 1624 Fifty years of penicillin Sir George Pickering, frcp, frs; V D Allison, md. 1625 Thalidomide and the Lancet IAH Munro, mb. 1625 Ocular complications of temporal arteritis B G Parsons-Smith, frcp. 1625 One-visit endoscopie clinic A N Chatterji, mrcp. 1626 Cervical cytology reporting O A N Husain, frcpath; R R Harrod, mb 1626 Pressure on trach?al mucosa from cuffed tubes D W Ryan, ffarcs. 1626 Indications for electric convulsion therapy Elizabeth A Burroughs, md. 1626 What the public wants to know Rosemary Faunch, mps. 1627  Dignity of Labour? Margot Jefferys, bsc. 1627 Self-injection of veterinary oil-emulsion vaccines P B Stones, frcpath. 1627 Marriage matters S W Waydenfeld, mrcgp. 1627 Obsessionalism and response to lithium E F Donnelly, phd, and others. 1627 Nebulised salbutamol in life-threatening asthma J S Milledge, frcp. 1628 New approach to treatment of recent stroke? G D Perkin, mrcp. 1628 Antibiotic-induced interstitial nephritis ? C T Flynn, mrcp. 1628 Treatment of tinnitus T K Daneshmend, mb. 1628 Dialysis and transplantation in young children D G Oreopoulos, frcp(c), and others_ 1628 History of an improvement R S C Howell, ffarcs. 1629 Doctors and children's teeth I P D Stocker. 1629 Cimetidine for hypertrophie prostate? M Cohen, frcs. 1629 The dilated upper urinary tract P H O'Reilly, frcs, and others. 1629 Biochemical testing for acute medical emergencies C Sanderson, bsc. 1629 Air embolism and intravenous catheters E Metcalfe, srn, and others. 1630 Captain Cook and scurvy B Williams, frcog. 1630 Vaccination and pregnancy Gillian C L du Mont, mrcp, and R C Beach, mrcp . 1630 An alternative to colostomy N R Parrott, mb, and H B Devlin, frcs. . 1630 Cyclophosphamide in chronic active hepatitis R Althouse, md, and others. 1630 Management and severity of tetanus J A Rennie, frcs. 1631 Medical reports and confidentiality D L Gullick, mb. 1631 Isolated communities and their doctors C G Elliott, bm. 1631 NHS certificates for hospital patients R L L Simmons, mrcog. 1631 Domesticated doctors Ruth E Ferguson, mb. 1632 Milage allowance P R J Vickers, frcs. 1632 Review Body report DJB Ashley, frcpath. 1632 Correction: Community medicine (Smithells) . 1632
The dangers of prejudice reduction interventions: Empirical evidence from encounters between Jews and Arabs in Israel
Authors: Ifat Maoz
Journal: Behavioral and Brain Sciences (2012)

Abstract This commentary focuses on Dixon et al.'s discussion on the dangers of employing prejudice-reduction interventions that seek to promote intergroup harmony in historically unequal societies. Specifically, it illustrates these dangers by discussing my work in Israel (now mentioned in Dixon et al.'s note 6) on the processes and practices through which reconciliation-aimed encounters between Jews and Arabs mitigate sociopolitical change.
Effects of l-carnitine administration on left ventricular remodeling after acute anterior myocardial infarction: the l-Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) trial
Authors: Sabino Iliceto, Domenico Scrutinio, Paolo Bruzzi, Gaetano D'Ambrosio, Luca Boni, Matteo Di Biase, Giuseppina Biasco, Paul G. Hugenholtz, Paolo Rizzon
Journal: Journal of the American College of Cardiology (1995)
Insulin-like Growth Factor I Plasmid Therapy Promotes in Vivo Angiogenesis
Authors: Eric D Rabinovsky, Ruxandra Draghia-Akli
Journal: Molecular Therapy (2003)

Angiogenesis, the formation of neovessels from the endothelium of preexisting vessels, is stimulated by soluble angiogenic factors. Insulin-like growth factor I (IGF-I) stimulates myogenesis and induces nerve regeneration after injury, and it has been shown to stimulate angiogenesis. However, the in vivo angiogenic effects of IGF-I in regenerating and diabetic muscle have yet to be described. Therefore, we studied the effects of human IGF-I (hIGF-I) delivered by a plasmid-mediated therapy on angiogenesis in mouse models of these two conditions. Plasmid hIGF-I was delivered to the injured tibialis muscle by direct intramuscular injection followed by electroporation. Initial experiments compared two muscle-specific hIGF-I-expressing constructs containing either a skeletal actin 3'UTR (pAV2001) or a human growth hormone (GH) 3'UTR (pAV2002). Skeletal actin 3'UTR mediates sequestration of hIGF-I in the muscle and was more active, while the GH 3'UTR mediated release of IGF-I into the circulation. Treatment of regenerating muscle with pAV2001 and sequestration of IGF-I in muscle led to increased expression of vascular endothelial growth factor (VEGF) and VEGF receptors fetal liver kinase-1 and FmS-like tyrosine kinase receptor-1, as well as platelet endothelial cell adhesion molecule-1, on endothelial cells. These results indicate that IGF-I can amplify angiogenic responses in regenerating muscle. In a mouse diabetic model, plasmid-mediated IGF-I therapy reversed diabetic microangiopathy, as shown by increased angiogenesis and arterial flow as analyzed by Doppler imaging. These studies show that plasmid IGF-I delivery and sequestration in muscle can augment angiogenesis in regenerating muscle and increase blood flow and angiogenesis in the diabetic limb.
Stroke volume from computerized analysis of digital color flow images: Comparison with transonic flow probe
Authors: Jeffrey S. Soble, Thomas Stamos, Beomjin Kim, Alex Neumann, JoAnne Schmitt, Mark J. Harry, Niraj Sehgal, Gary L. Schaer, Tony Hursey, James Robergé, Richard H. Marcus
Journal: Journal of the American College of Cardiology (1996)
Effect of dietary supplementation with n-9 eicosatrienoic acid on leukotriene B4 synthesis in rats: a novel approach to inhibition of eicosanoid synthesis.
Authors: M J James, R A Gibson, M A Neumann, L G Cleland
Journal: The Journal of Experimental Medicine (1993)

Studies were undertaken to assess the biochemical effects of dietary supplementation with n-9 eicosatrienoic acid (ETrA), an arachidonic acid analogue that is normally present in cell membranes at very low levels but is raised in the presence of essential fatty acid deficiency (EFAD). The incorporation of dietary ETrA into rat neutrophils and its effect on A23187-stimulated 5-lipoxygenase metabolism in these cells was examined; in addition, the effect of ETrA was compared with that of another arachidonic acid analogue, eicosapentaenoic acid (EPA), which is known to accumulate in cell membranes and inhibit synthesis of leukotriene B4 (LTB4) a product of the 5-lipoxygenase metabolic pathway. Rats were fed a defined diet that was sufficient in essential fatty acids and that contained EPA or ETrA (0.014% of energy) or no added fatty acid, for 3 wk. In the cells from ETrA-fed rats, LTB4 synthesis was inhibited relative to control values, but synthesis of the other products of 5-lipoxygenase metabolism, 5-hydroxyeicosatetraenoic acid (5-HETE) and the all-trans isomers of LTB4, were not inhibited. This pattern indicates inhibition of LTA hydrolase in ETrA-fed rats. In EPA-fed rats, there was inhibition of LTB4 and the all-trans isomers of LTB4, but there was no inhibition of 5-HETE. This pattern indicates inhibition of LTA synthase in EPA-fed rats. The results establish that dietary ETrA effectively inhibits synthesis of the inflammatory mediator, LTB4, and suggest that ETrA may confer antiinflammatory benefits similar to those observed with EFAD or dietary fish oil (which contains EPA). Because ETrA is substantially less unsaturated than EPA, it can be expected to have greater chemical stability, which could be an important practical advantage when used as a dietary constituent or supplement.
Teaching the Diagnostic and Healing Qualities of Story
Authors: Kevin Koo
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Male Pseudohermaphroditism: A Hitherto Undescribed Form
Authors: G. I. M. Swyer
Journal: BMJ (1955)

MEDICAL JOURNIAL clear view.If traction is maintained on the spleen, pancreas, and splenic vessels the tension on the splenic artery is trans- mitted to the coeliac axis and consequently to the aorta and renal artery, and the adrenal vessels and sympathetic nerves, and so the adrenal gland itself, are fixed.This manceuvre may alter the position of the gland, to the operator's advant- age, by 3-4 cm.(Fig. 2).The gland can then be dissected under vision, its vessels ligated, and the gland removed entire.The retroperitoneum in the area is then inspected for the presence of accessory adrenal tissue.Attention is now v turned to the right * TeFarscia side, and the right adrenal is sought in the area bound-Kidnq 11 \\ ed by the lower Aorta border of the right t Peritonewan lobe of the liver,
Nontherapeutic Problems of Generic Drugs Lead to Call for FDA, Legislative Diagnosis and Cure
Authors: Charles Marwick
Journal: JAMA (1989)

GENERIC DRUGS, the favored child of medical care cost cutters, have come under suspicion following revelations that some manufacturers may have engaged in dubious manufacturing and testing practices and about the bribing of Food and Drug Administration (FDA) employees. The Inspector General's Office in the Department of Health and Human Services investigated these allegations under the auspices of the US Attorney's Office. Subsequently criminal charges were lodged. To date, three FDA employees, three drug company employees, and two companies have pleaded guilty to charges of corruption, says a report by Richard Kusserow, the department's inspector general. At the same time, "there is no evidence to date to suggest the quality of generic drug products has been compromised," says Louis W. Sullivan, MD, secretary of the Department of Health and Human Services. Frank E. Young, MD, FDA commissioner, agrees, and the two officials have announced steps to put tighter controls on
How to take blood from patients who have hepatitis B.
Authors: P D Welsby
Journal: BMJ (1981)

Junior medical staff are often advised to  careful and to take care when taking blood from patients with hepatitis B or from carriers of the hepatitis B virus. Unfortunately, such advice is rarely more specific and no doubt usually causes more worry than reassurance. Additionally, it should not be forgotten that many patients may be unsuspected carriers of the hepatitis B virus, and routine bloodletting can never be considered to be entirely without risk of hepatitis B infection. As there is a surprising lack of specific advice I have given the problem of safe bloodletting much thought, and I think the following scheme the most sensible approach. Nevertheless, I would welcome both constructive and other comments on my suggestions.
PET Imaging With p-[I-124]iodo-l-phenylalanine as a New Tool for Diagnosis and Postoperative Control in Patients With Glioma
Authors: Georgios Farmakis, Wolfgang Brandau, Dirk Hellwig, Frank Wollenweber, Andrea Schaefer, Carl-Martin Kirsch, Samuel Samnick
Journal: Clinical Nuclear Medicine (2008)

Imaging protein metabolism by means of radiolabeled amino acids is an established method in the diagnosis of brain tumors. I-123 iodo-l-phenylalanine is a novel iodinated amino acid currently used for brain tumor imaging with single photon emission computed tomography. Radiolabeling of l-phenylalanine with iodine-124 allows in vivo studies of brain tumors by positron emission tomography, improving image quality. In this report, we evaluate the pre- and postoperative status in a 73-year-old patient with a glioma after one single injection of I-124 IPA using PET. A single administration of I-124 p-iodo-L-phenylalanine approved both an accurate diagnosis and a postoperative control in this same patient with a glioma.
Comparison of Clinical and Angiographic Parameters Right Coronary Artery Shapes in Patients With Acute Myocardial Infarction from Right Coronary Artery
Authors: Mehmet Sait Altıntaş, Necip Ermiş, Bilal Çuğlan, Erdal Altürk, Ramazan Özdemir
Journal: Journal of the American College of Cardiology (2013)
Occupational and Economic Factors of Mortality
Authors: None Greenwood
Journal: BMJ (1939)

that may take place, and the degree of "give in the pelvic circumference can never be predicted with certainty.Radiography and careful manual and instrumental pelvi- metry combined will reduce the number of borderline cases -in other words, we will be able to predict with a greater degree of certainty whether the head will or will not pass through the brim and well down into the cavity.It will be noted that I do not include the outlet; that is a problem of its own to which I intend to refer in my second lecture.Let me quote here what DeLee (1938b) says:"Therefore while developing a 'roentgen eye' don't fail to confirm what you see with it with what you see with the obstetric eyes ' on the tips of your-fingers.Then, also, don't forget that the pains are the most important element in a labour and only labour itself can tell you how much they are able to do."
Breast feeding and my brain
Authors: M. E Black
Journal: BMJ (1999)

I've got my brain back. I have finally weaned the youngest, the hormones are almost back to prepregnancy levels, and there is a distinct feeling of the fog clearing after three and a half years.

As a junior doctor, I had messianically and rather glibly extolled the virtues of breast feeding. When my own turn came, I found that the reality was indeed rewarding, but it proved to be an unexpectedly major undertaking. Never mind the cracked nipples, mastitis, and leaks—it was thesheer time involved. Over the past 40 months I have breast fed for around 3600 hours. That is an average of three hours a day (range one to six hours; case definition: time directly feeding and commuting time to get to baby during lunch breaks). This is the equivalent of a 40 month half time job if you adjust for a five day week and take into account holidays.

Impassioned by how hard it was in practice …