tbuckley/cabot-search huggingface dataset:
Cataract in developing countries.
Authors: D. Yorston, A. Foster
Journal: BMJ (1992)

however, is open to error.A considerable educational effort would be required to alter established prescribing habits.To complicate matters further, the title of the products on the datasheet does not reflect the name printed on our stock of the reformulated product.Omnopon Paediatric is actually packaged and labelled as Omnopon 10 with no reference to paediatric on the box.We believe that the risk of the wrong strength of Omnopon being prescribed and administered is great and does not warrant its continued use.
Fibroblast growth factor 23 and 25-hydroxyvitamin D levels are associated with estimated glomerular filtration rate decline
Authors: Takayuki Hamano, Chikako Nakano, Yoshitsugu Obi, Naohiko Fujii, Isao Matsui, Kodo Tomida, Satoshi Mikami, Kazunori Inoue, Akihiro Shimomura, Yasuo Kusunoki, Hiromi Rakugi, Yoshitaka Isaka, Yoshiharu Tsubakihara
Journal: Kidney International Supplements (2013)
763. Optimization of Plasmid Components for Gene Therapeutic Purposes
Authors: Ruxandra Draghia-Akli, Melissa A. Pope, Amir S. Khan
Journal: Molecular Therapy (2005)

Introduction: We have recently optimized our plasmid-based expression system for gene therapeutic purpose. These changes allow us to tailor our plasmid to maximally express any transgene in muscle, without the use of viral particles or other vectors.
Syphilis and Leprosy-Reply
Authors: Yehudi M. Felman
Journal: JAMA (1982)

In Reply.—  Dr Murray's letter concerning simultaneous syphilis and HD poses some interesting questions. It is well known that from 10% to 40% of patients with lepromatous leprosy have false-positive reagin serological tests for syphilis. 1 However, in these patients specific treponemal tests such as the FTA-ABS, TPI, and MHA-TP tests are generally negative. 2   Current incidence rates of syphilis in the United States do not approach the percentage of syphilis cases detected in Dr Murray's study population, indicating that patients with HD are at high risk. The highest incidence rate recorded in the United States from 1940 to 1979 for all stages of syphilis was in fiscal year 1943, at a rate of 447/100,000 population. 3 Except for some occasional minor upward fluctuations, the rate for total syphilis in the United States has been steadily declining to a rate of 30.7/100,000 in 1979. Mathematically, 447/100,000 equals 0.447%. This figure
Partial Thromboplastin Time for Screening
Authors: N.G. BARANETSKY
Journal: Annals of Internal Medicine (1979)

Letters1 September 1979Partial Thromboplastin Time for ScreeningN.G. BARANETSKY, M.D., PAUL WEINSTEIN, M.D.N.G. BARANETSKY, M.D.Search for more papers by this author, PAUL WEINSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-3-498 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read the report of Robbins and Rose in the May 1979 (1) with an interest heightened by our own experience. At our institution, the partial thromboplastin time is now measured in nearly all surgical and many medical patients, regardless of the clinical setting. After the first 15 months of this practice, we reviewed the partial thromboplastin times of approximately 2600 patients and found that the large majority of abnormal values could have been predicted from the admission history and physical examination, as judged by a retrospective chart review. However, five patients in our series had unexplained...References1. ROBBINSROSE JS. Partial thromboplastin time as a screening test. Ann Intern Med. 1979;90:796-7. LinkGoogle Scholar2. HOUGIE C. Hemophilia and related conditions: congenital deficiencies of prothrombin (factor II), factor V, factors VII to XII. In: WILLIAMS WJ, BEUTLER E, ERSLER E, RUNDLES RW, eds. Hematology. New York: McGraw-Hill; 1972:1193-1209. Google Scholar3. Hereditary coagulation disorders. In: WINTROBE MM, LEE GR, BOGGS DR, ATHENS JW, FOERSTER J, eds. Clinical Hematology. Philadelphia: Lea & Febiger; 1974:1158-1200. Google Scholar4. CONRADBRENEMANGRISHAM FWD. A clinical evaluation of plasma thromboplastin antecedent (PTA) deficiency. Ann Intern Med. 1965;62:885-98. LinkGoogle Scholar5. SELLER R. Parahemophilia: factor V deficiency. Med Clin North Am. 1972;56:119-25. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: N.G. BARANETSKY, M.D.; PAUL WEINSTEIN, M.D.Affiliations: The Stamford Hospital Stamford, CT 06902 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA prospective multicenter evaluation of preoperative hemostatic screening testsMONITORING THE COAGULATION SYSTEM 1 September 1979Volume 91, Issue 3Page: 498-499KeywordsChartsPartial thromboplastin time ePublished: 1 December 2008 Issue Published: 1 September 1979 PDF downloadLoading ...
Zidovudine in Asymptomatic Human Immunodeficiency Virus Infection
Authors: Paul A. Volberding, Stephen W. Lagakos, Matthew A. Koch, Carla Pettinelli, Maureen W. Myers, David K. Booth, Henry H. Balfour, Richard C. Reichman, John A. Bartlett, Martin S. Hirsch, Robert L. Murphy, W. David Hardy, Ruy Soeiro, Margaret A. Fischl, John G. Bartlett, Thomas C. Merigan, Newton E. Hyslop, Douglas D. Richman, Fred T. Valentine, Lawrence Corey
Journal: New England Journal of Medicine (1990)

Zidovudine (AZT) is a potent inhibitor of the replication of the human immunodeficiency virus (HIV), and it has been shown to improve survival in advanced HIV disease. We conducted a randomized, double-blind trial in adults with asymptomatic HIV infection who had CD4+ cell counts of fewer than 500 per cubic millimeter on entry into the study. The subjects (92 percent male) were randomly assigned to one of three treatment groups: placebo (428 subjects); zidovudine, 500 mg per day (453); or zidovudine, 1500 mg per day (457).
Studies on the site of fat absorption: 1. The sites of absorption of increasing doses of 131I-labelled triolein in the rat
Authors: C. C. Booth, A. E. Read, E. Jones
Journal: Gut (1961)

These studies on fat absorption in rats show that a small dose was relatively rapidly absorbed in the jejunum. With larger doses it was also absorbed in the ileum. When larger doses were given the jejunum responded to the increased load with an increased absorption, and fat was also absorbed in the ileum.
The Action of Parathyroid Hormone.
Authors: Howard Rasmussen
Journal: Annals of Internal Medicine (1965)

s1 May 1965The Action of Parathyroid Hormone.Howard Rasmussen, M.D.Howard Rasmussen, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1074_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwo of the most widely held theories of hormone action are: (1) hormones act by altering the transport of substances across membranes and (2) hormones act by altering genetic expression within cells. Much recent work suggests that one of the most basic effects of parathyroid hormone is upon the transport of calcium, magnesium, phosphate, and potassium across cellular and subcellular membranes. The addition of hormone to isolated mitochondria in vitro leads to a redistribution of all these ions across the mitochondrial membrane. This ionic redistribution is similar to that which the hormone produces across the renal tubule. This effect of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1074-1074KeywordsCalciumCellsGeneticsHormonesMagnesiumMitochondriaParathyroid hormonePhosphatesPotassium Issue Published: 1 May 1965 PDF DownloadLoading ...
Cytokine inhibition of the hepatitis B virus core promoter
Authors: R Romero, J E Lavine
Journal: Hepatology (1996)

Hepatitis B virus (HBV) DNA contains consensus elements for transactivating proteins whose binding activity in other systems is regulated by inflammatory cytokines. Because HBV replicates within an environment of provoked inflammation, we speculated that the HBV core/pregenomic promoter may be regulated by cytokines produced in response to infection. To evaluate this hypothesis, the HBV core/pregenomic (C/P) promoter and associated cis -acting elements were placed upstream of a luciferase-encoding plasmid. This reporter construct was transfected into cytokine-sensitive hepatoma cells permissive for HBV replication, which were exposed to stimulated mononuclear cell-conditioned medium or human recombinant cytokines. Conditioned medium reduced luciferase expression by 80%. Tumor necrosis factor α (TNF-α), interferon gamma (IFN-γ), and interferon alfa (IFN-α) each reduced luciferase activity by 40%. Combinations of TNF-α and interferons mimicked the extent of conditioned medium inhibition. Non-specific effects from diminished cellular viability or growth were not responsible for decreased luciferase activity. Retention of HBV DNA 330 basepairs upstream of the C/P transcription start site was required to maintain the TNF-α effect. A 60% reduction in HBV replicative forms within intracellular core particles was demonstrated with TNF-α treatment of Hep G2 cells stably transfected with HBV DNA. The inhibitory action of these cytokines implicates a noncytolytic mechanism by which antigen-nonspecific immune responses in part regulate HBV replication in infected hepatocytes. This function may be beneficial in accelerating viral clearance, but in alternative circumstances could contribute to viral persistence by attenuating immunogen recognition.
The New Nurse and the New Physician
Authors: CAROL J. PETERSON
Journal: Annals of Internal Medicine (1982)

Editorials1 March 1982The New Nurse and the New PhysicianCAROL J. PETERSON, PH.D., R.N.CAROL J. PETERSON, PH.D., R.N.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-3-374 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe National Commission on Nursing was created in 1980 by the American Hospital Association, Hospital Research and Educational Trust, and American Hospital Supply Corporation to serve as an independent body for inquiry into the nationwide nursing shortage and related issues in hospital management, nursing practice, and nursing education. With a roster of 30 commissioners from nursing, hospital management, and medicine that reads like a Who's Who in the health care field, the commission has received nationwide written and oral testimony on the various issues within its charge. The Commission's recently publishedInitial Report and Preliminary Recommendationsdeals extensively with the...References1. . Initial Report and Preliminary Recommendations. Chicago: The Hospital Research and Educational Trust; 1981:p. 10. (Available from the American Hospital Association, 840 North Lakeshore Drive, Chicago, IL 60601) Google Scholar2. See Reference 1, p. 15. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: College of Nursing South Dakota State University Brookings, South Dakota PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Changing Role of Nurses and Its ImplicationsEthical Dimensions of the Physician-Patient Relationship 1 March 1982Volume 96, Issue 3Page: 374-375KeywordsHealth careHospital medicineNursesNursing educationOral healthOral medicine Issue Published: 1 March 1982 PDF DownloadLoading ...
BRAF Inhibitors for the Treatment of Metastatic Melanoma: Clinical Trials and Mechanisms of Resistance
Authors: Alexander Marzuka Alcalá, Keith T. Flaherty
Journal: Clinical Cancer Research (2012)

Abstract The efficacy of selective BRAF inhibitors has now been established in the 50% of patients with metastatic melanoma whose tumors harbor activating mutations. However, for the vast majority of patients, responses persist for less than a year. In extensive preclinical investigations, researchers have focused on potential resistance mechanisms with the hope of identifying treatment strategies that can overcome resistance. Preliminary results suggest that reactivation of the mitogen-activated protein kinase (MAPK) pathway by several BRAF-independent mechanisms is the predominant pattern. However, MAPK pathway–independent mechanisms also seem to play a potential role. More definitive cataloging of resistance mechanisms in patients' tumor samples is needed as combination regimens are being readied for clinical evaluation. Clin Cancer Res; 18(1); 33–9. ©2012 AACR.
A Disquieting Comparison
Authors: Lee N. Hames
Journal: JAMA (1970)

Many Americans, both young and old, are campaigning and protesting against the war in Vietnam. Our newspapers are full of dramatic stories, ranging from accounts of peaceful picketing and sit-ins to violent sieges and riots. Although the motivation of the antiwar campaigns often arises for other reasons, some of it at least is in protest against the war casualties. But, strangely, there is little reaction to a slaughter that is ten times as great. In fact, last year, the slaughter on American highways took the lives of more Americans in only nine months than were killed in the entire nine-year Vietnam War. Antiwar campaigners might argue that the Vietnam deaths are needless, which would imply that those on our highways are not. Also, it might be argued that the war takes the youth of our nation. However, two to three times as many youths under 24 are killed on our
Hyperventilation and Sphygmomanometry
Authors: Harry F. Klinefelter
Journal: JAMA (1973)

<h3>To the Editor.—</h3> During 30 years of practice, I have relied on hyperventilation to determine if the patient really has high blood pressure or whether the elevation of blood pressure is due to tension factors. Since so much emphasis is correctly being placed on treatment of hypertension, it is important not to treat patients unless they need treatment. Many patients, when first examined and even after repeated visits to the same physician, will have an elevated blood pressure that falls to normal after a minute or two of hyperventilation. Some patients seem to react with a high reading simply by having the blood pressure cuff put on their arms and do not have true hypertension. I have asked many physicians interested in cardiovascular disease, and they do not know of any work that has been done on this. They seem to have no interest or enthusiasm in doing any investigative
Natural history of gastro-oesophageal reflux disease without oesophagitis.
Authors: F Pace, F Santalucia, G Bianchi Porro
Journal: Gut (1991)

This retrospective study was undertaken to characterise the clinical course and reflux pattern of patients with gastro-oesophageal reflux without evidence of oesophagitis. We investigated 33 patients (12 women, 21 men; mean age 36 years) with typical symptoms, a negative oesophagoscopy, and a 24 hour oesophageal pH-metry indicative of pathological gastro-oesophageal reflux. All patients received antacids or prokinetic drugs or both for three to six months. Nineteen of 33 patients still had symptoms at the end of treatment, of whom five had developed erosive changes of the oesophageal mucosa. The other 14 discontinued treatment and remained asymptomatic during a six month follow up period. Comparison of the pretreatment pH-metry data of the 19 symptomatic patients and the 14 asymptomatic patients showed no differences in the pattern of gastro-oesophageal reflux in the two groups. We conclude that in a substantial proportion of patients with pathological reflux without oesophagitis symptoms may persist and mucosal lesions may develop during conventional treatment without any apparent change in the reflux. Patients who developed endoscopic oesophagitis did not have a more severe pretreatment pattern of gastro-oesophageal reflux when compared with those who did not develop oesophageal mucosal damage.
Fibre and patients with diabetes
Authors: A Lakhdar, E Farish, E H McLaren
Journal: BMJ (1988)

It is no longer justifiable for one physician to spend twice as much money as another on treating patients with similar diseases,"3 yet it is almost embarrassing to report that only the private sector seems to be using well researched, humane, and acceptable techniques which reduce the duration of opiate withdrawal from the usual two to three weeks to two to three days or less.6
STENT FRACTURE AND ANGIOGRAPHIC PERI-STENT ABNORMAL FINDING AFTER SIROLIMUS-ELUTING STENT IMPLANTATION
Authors: Kazushige Kadota, Kazuaki Mitsudo, Tsuyoshi Goto, Satoki Fujii, Hiroyuki Yamamoto, Harumi Katoh, Naoki Oka, Yasushi Fuku, Shingo Hosogi, Yoshiharu Nishibori, Akitoshi Hirono, Takeshi Maruo, Hiroyuki Tanaka, Seiji Habara, Yoshikazu Shigemoto, Daiji Hasegawa, Ippei Kosedo, Hiroshi Tasaka, Masao Imai, Mana Kusunose, Yoji Okamoto, Suguru Otsuru, Naoki Saito, Kentaro Shibayama, Yuki Tsujimoto
Journal: Journal of the American College of Cardiology (2010)
MEMBRANOUS DYSMENORRHEA AS A SYMPTOM OF DIABETES
Authors: Robert D. Spencer
Journal: JAMA (1924)

The etiology of membranous dysmenorrhea is obscure. It has been found as a complication of certain pelvic diseases, and it has developed after an attack of one of the exanthems. Whenever it has been observed, marked nutritive changes seem to be closely related to the production of this rare condition.  The case reported here illustrates a metabolic disease, apparently the etiologic factor.  Mrs. E., aged 40, came to the Ashland State Hospital, May 14, 1924, her chief complaint being the passing of a fleshy mass at menstruation, which she had been observing for the past year. The fleshlike mass escaped about the seventh day of her periods, which were quite regular. She also complained of a great loss in weight, and frequent urgent urination. Examination of the blood showed the sugar content to be 0.25 mg. The urine also contained sugar. The patient was placed on a diet, and in
67Ga Scintigraphy in Lymphomas with Special Reference to Cardiac Apical Mass
Authors: O L MANFREDI, R SUNDARAM, F M RAMADAN, J ARUNY
Journal: Clinical Nuclear Medicine (1978)

The cardiac apical mass of Hodgkin's disease, an infrequent presentation of lymphomas, can be selectively labeled with 67Ga-citrate. Three cases are presented illustrating the value of 67Ga scintigraphy in the differential diagnosis of pericardial masses, as well as its role in the management and assessment of therapy.
A piece of my mind. The benefit of the doubt
Authors: C. M. Callahan
Journal: JAMA (1990)

Alberta Johnson is an obese woman with diabetes and hypertension. I've admitted to myself that I'll never really be able to comprehend the physical and social struggles of her past, present, or future. I've never been a victim of poverty, unwanted pregnancy, ineffective schooling, or job discrimination. In fact, I've never been a victim of anything. Ms Johnson gains about 25 pounds per year and takes her medications, or maybe her mother's, when she doesn't feel well. She never misses an appointment though, because inevitably she has a sore knee, or indigestion, or a fungal rash that I didn't quite fix the last time. She also feels compelled to point out the deficiencies of the social net at each visit. I get angry at Ms Johnson because she won't meet me halfway. She points out that I don't even know where halfway is. Frank Tarkin is an angry man with
"Oblomov Syndrome"? ("Oblomov Sign"?)
Authors: Wladyslaw Wermut
Journal: JAMA (1975)

To the Editor.—  I was particularly interested in the statement of N. S. Kline, MD, that refusal to get out of bed may be one of symptoms of depression (227:1158, 1974).  Taking into consideration the existing tendency to seek literary archetypes for various clinical syndromes, eg, Pickwickian syndrome, Munchausen syndrome, Ondine syndrome, Musset syndrome, I would like to note that the refusal to get out of bed also has a representative in belles lettres. It's Ilya Ilych Oblomov, leading character of Oblomov , a novel written in 1859 by the Russian classic author, Ivan Gentcharov (1812-1891). Through 131 pages (one third of the book!), Oblomov, a 32-year-old nobleman, refuses to get out of bed. Throughout many hours he tries to overcome his passivity but without result. This part of the book is deeply disturbing. After many sad events, over a couple of years, Oblomov dies of cerebral hemorrhage.  Taking all this
Euthanasia for Minors in Belgium—Reply
Authors: Andrew M. Siegel, Dominic A. Sisti, Arthur L. Caplan
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Differential Radiation Dermatitis in Native Skin and an Autologous Transplanted Myocutaneous Flap
Authors: Viswanath R. Belum, Amanda Hill, Evan Matros, Mario E. Lacouture, Christopher A. Barker
Journal: JAMA Dermatology (2014)

CAM use is similar among those who do and do not attend dermatology outpatient clinics.Our results suggest that CAM is used more often in chronic skin conditions (eg, acne and eczema) rather than in acute skin conditions.Herbal therapies are the most commonly used CAM and may reflect that CAM therapies typically rely on herbal treatments.There are several limitations to this study.Our survey was limited to English, and the respondents were predominantly of white ethnicity.Complementary and alternative edicine use is more prevalent among those who are nonwhite, 3,6 and this may explain why our prevalence rates are lower than studies that have examined a more general US population. 1,2Our sampling is representative of Sacramento, California.Broader studies involving other regions are needed before drawing conclusions that would be relevant to a more general population.Because we conducted the survey anonymously, self-reported diagnoses could not be verified.Physicians need to be aware that their patients may be engaged in CAM use for skin-related conditions, such as acne and eczema.