tbuckley/cabot-search huggingface dataset:
Abstract 5206: Role of CtBP1 as a transcriptional corepressor in prostate cancer.
Authors: Balabhadrapatruni V. S. K. Chakravarthi, Satya Pathi, Heng Zheng, Javed Siddiqui, Lakshmi P. Kunju, Nallasivam Palanisamy, Sooryanarayana Varambally
Journal: Cancer Research (2013)

Abstract Background: C-terminal Binding Protein 1 (CtBP1), a transcriptional co-repressor that regulates the expression of tumor suppressors and genes involved in cell death, is known to play a critical role in multiple cancers. Earlier, we showed that CtBP1 is overexpressed in metastatic prostate cancer. Furthermore, our studies indicated a role for CtBP1 in conferring radiation resistance to prostate cancer cell lines. We also demonstrated the functional role of CtBP1 in regulating prostate cancer cell growth in vitro and tumor growth and metastasis in vivo. Methods and Results: Our gene expression profiling and bioinformatics analysis found that multiple potential tumor suppressors are reactivated upon CtBP1 knockdown in multiple prostate cancer cell lines. We next validated these targets of CtBP1-mediated repression by qRTPCR and western blotting using CtBP1 stable knockdown prostate cancer cell lines, and in normal prostate epithelial PrEC cells overexpressing CtBP1. Our studies confirmed that CtBP1 targets multiple genes including SP8 transcription factor and kallikrein-related peptidase 10 (KLK10) among others. Knockdown of the reactivated gene led to a reversion of these cells to a more aggressive phenotype. Furthermore, our studies confirmed that the CtBP1 target genes are down-regulated in metastatic prostate cancer. Conclusion: Taken together, our studies demonstrated that dysregulated expression of CtBP1 plays an important role in prostate cancer progression by down-regulating the expression of multiple potential tumor suppressor genes. Thus, targeting CtBP1 in aggressive prostate cancer may have clinical significance. Citation Format: Balabhadrapatruni V. S. K. Chakravarthi, Satya Pathi, Heng Zheng, Javed Siddiqui, Lakshmi P. Kunju, Nallasivam Palanisamy, Sooryanarayana Varambally. Role of CtBP1 as a transcriptional corepressor in prostate cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5206. doi:10.1158/1538-7445.AM2013-5206
Allergen-dependent solubilization of IL-13 receptor α2 reveals a novel mechanism to regulate allergy
Authors: Michael O. Daines, Weiguo Chen, Yasuhiro Tabata, Bradley A. Walker, Aaron M. Gibson, J. Alexander Masino, Manoj R. Warrier, Cori L. Daines, Sally E. Wenzel, Gurjit K. Khurana Hershey
Journal: Journal of Allergy and Clinical Immunology (2006)
Gouty Arthritis and Polycystic Kidney Disease
Authors: DAVID S. NEWCOMBE
Journal: Annals of Internal Medicine (1973)

Letters1 October 1973Gouty Arthritis and Polycystic Kidney DiseaseDAVID S. NEWCOMBE, M.D.DAVID S. NEWCOMBE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-4-605 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The incidence of acute gouty arthritis as a complication of chronic nongouty renal disease is less than 1% (1, 2). Of a total of 11 unrelated patients with adult polycystic disease seen at our institution over the past 4 years, 4 have had documented acute gouty arthritis. This high incidence (36%) of gout occurring in polycystic kidney disease suggests that investigation of urate metabolism in this heritable disorder might help to resolve the following problems: [1] the effect of hyperuricemia on the functionally compromised kidney; [2] the effect of hypouricemic therapy on the progression of the renal...References1. RICHETMIGNONARDAILLOU GFR: Goutte secondaire der néphropathies chroniques. Presse Med 73:663-638, 1965 Google Scholar2. SARREMERTZ HD: Sekundäre Gicht bei Neireninsuffizienz. Klin Wochenschr 43:1134-1140, 1965 CrossrefMedlineGoogle Scholar3. BEN-TSHAYDREYFUSSULLMANN DFT: Fanconi syndrome with hypouricemia in an adult. Am J Med 31:793-800, 1961 CrossrefMedlineGoogle Scholar4. STEELERIESELBACH TR: The renal mechanisms for urate homeostasis in normal man. Am J Med 43:868-875, 1967 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Rheumatology University of Vermont College of Medicine Burlington, Vermont PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGout and Polycystic Disease of KidneyJULIO V. RIVERA, M.D. 1 October 1973Volume 79, Issue 4Page: 605-605KeywordsUric acid Issue Published: 1 October 1973 PDF downloadLoading ...
Identification of Pretreatment Agents to Enhance Adenovirus Infection of Bladder Epithelium
Authors: Nagarajan Ramesh, Bahram Memarzadeh, Ying Ge, David Frey, Melinda VanRoey, Virginia Rojas, De-Chao Yu
Journal: Molecular Therapy (2004)

Adenovirus has been used widely as a gene transfer vector in the laboratory and clinic for the purpose of gene therapy. Conditionally replication-competent oncolytic adenoviruses are capable of multiplying up to a thousand old in target cells, a property that might prove to be of tremendous potential in the area of cancer therapy. Intravesicular therapy of refractory superficial bladder cancer employing an oncolytic adenovirus would allow for local administration and efficient delivery of virus to bladder tumor. The glycosaminoglycan layer on the surface of the bladder urothelium acts as a nonspecific antiadherence barrier and may be a significant roadblock to efficient infection of the urothelium by adenoviruses. Several laboratories have investigated the potential utility of bladder pretreatment with chemical agents to enhance the adenovirus infection of bladder urothelium but with limited success. A class of compounds has been identified that is effective for pretreatment of urothelium, permitting efficient adenoviral infection. In a murine model, pretreatment of the bladder with 0.1% dodecyl-β-d-maltoside (DDM) or sodium dodecyl sulfate (SDS) for 5 min resulted in >90% transduction of the urothelial layer within 15 min after exposure to a replication-defective adenovirus compared to ≤5% transduction in untreated bladders. DDM could be coformulated with adenovirus, and complete transduction of the urothelium was achieved following retention of the admixture in the bladder for 45 min. A similar enhancement of adenoviral infection following pretreatment of bladder with DDM and SDS was observed in a rat model. The use of these compounds may facilitate the development of adenovirus-based therapy for bladder cancer.
The African connection. Cotton Mather and the Boston smallpox epidemic of 1721-1722
Authors: T. H. Brown
Journal: JAMA (1988)

The contributions of black Americans to early American culture have still not been fully explored or given the attention deserved. A case in point is the significant contributions African slaves made to 18th-century American folk medicine. A review of the events incident to the smallpox epidemic in Boston in 1721 will illustrate the degree to which some reputable men of science depended on the testimony and experience of Africans in dealing with a particularly dread disease. (<i>JAMA</i>1988;260:2247-2249)
Acute Respiratory Failure in the Adult
Authors: H. Pontoppidan, B. Geffin, E. Lowenstein
Journal: New England Journal of Medicine (1972)

Trends in Treatment of Acute Respiratory FailureFOR several years after paralytic poliomyelitis became a rare disease, the use of artificial ventilation in treatment of acute respiratory failure was infrequent. During the past decade this trend has rapidly changed.1 The yearly number of patients treated with prolonged artificial ventilation at the Massachusetts General Hospital, which in 1958 amounted to 66, is now 1400 to 1500. In 1971 such cases accounted for 7230 patient days. Over the past decade more than 7000 patients have been so treated.Where and by whom should the burgeoning number of patients requiring artificial ventilation be . . .
Using the Delphi Technique to Determine Which Outcomes to Measure in Clinical Trials: Recommendations for the Future Based on a Systematic Review of Existing Studies
Authors: Ian P. Sinha, Rosalind L. Smyth, Paula R. Williamson
Journal: PLoS Medicine (2011)

Ian Sinha and colleagues advise that when using the Delphi process to develop core outcome sets for clinical trials, patients and clinicians be involved, researchers and facilitators avoid imposing their views on participants, and attrition of participants be minimized.
Personality Factors and Patterns of Drug Usage in College Students
Authors: C. P. McAREE, R. A. STEFFENHAGEN, L. S. ZHEUTLIN
Journal: American Journal of Psychiatry (1972)

Under a grant of immunity from prosecution, the authors tested 100 student drug users and 100 nonusers, who also had immunity. They categorized the drug users as marijuana-only users, multiple-drug users, or gross-multiple-drug users. Using the Minnesota Multiphasic Personality Inventory as a criterion, they found that the gross-multiple users had the highest incidence of abnormal profiles and that they, as well as the multiple users, evidenced more psychopathology than the marijuana-only users or the nonusers.
Comparison of Incidence of IDDM in Childhood Between Estonia and Finland, 1980–1988
Authors: Jaakko Tuomilehto, Toomas Podar, Antti Reunanen, Irina Kalits, Raisa Lounamaa, Eva Tuomilehto-Wolf, Bela Adojaan, Barbara Neff, Ronald E LaPorte
Journal: Diabetes Care (1991)

Objective To compare nationwide incidence of childhood insulin-dependent diabetes mellitus (IDDM) in children aged 0-14 yr between Estonia and Finland during 1980-1988. For Estonia, which has a population genetically and linguistically related to Finland, only limited information was available. Finland has the highest incidence of IDDM in the world. Research Design and Methods The registration of all new cases of IDDM in Estonia was conducted by the local district pediatricians who reported every newly diagnosed diabetic patient to the Republic Endocrinology Centre. Registration of all new cases of IDDM in Finland was based on the statistics of the Social Insurance Institution, which approves free-of-charge insulin treatment for diabetes. These data were validated with one or more additional data sources. The case ascertainment rate approached 100% in both countries. Results The average yearly incidence of IDDM standardized for age for the years 1980–1988 in Estonia was ~ 33% of that in Finland. Among males it was 11.3 (95% confidence interval [CI] 10.3–12.3) per 100,000 in Estonia and 35.1 (95% CI 33.4–36.9) per 100,000 in Finland, and among females 10.1 (95% CI 9.2–11.1) per 100,000 in Estonia and 30.4 (95% CI 28.8–32.1) per 100,000 in Finland. When the two periods 1980–1982 and 1986–1988 were compared, the age-standardized incidence in Estonia remained unchanged, whereas in Finland it increased ~ 20%. Conclusions The data between two populations who are ethnically and linguistically similar and live geographically close but in a different environment, provides further evidence that both genetic and environmental factors are contributing to the risk of IDDM.
Effect of alpha-glucosidehydrolase inhibition and intestinal absorption of sucrose, water, and sodium in man.
Authors: W F Caspary, H Kalisch
Journal: Gut (1979)

The effect of a new complex oligosaccharide exhibiting potent inhibitory action on ax-glucoside hydrolases on intestinal absorption of sucrose in man was tested by constant in vivo perfusion of the jejunum.At concentrations of 4-65 or 155 x 10-6M the ac-glucosidehydrolase inhibitor (a-GHI) markedly inhibited absorption of glucose from sucrose and absorption of sodium and water.Oral administration of the a-GHI resulted as well in depression of solute, sodium, and water absorption.This new compound can serve as an interesting tool to induce carbohydrate malabsorption by inhibition of final digestion and may possibly be of beneficial therapeutic effect in dietary control of diabetes or obesity.
Temperature dependence of water content of stratum corneum
Authors: T.S. SPENCER, C.E. LINAMEN, W.A. AKERS, H.E. JONES
Journal: British Journal of Dermatology (2006)

The water content of human stratum corneum has been measured gravimetrically in vitro in relation to relative humidity (RH) and temperature. Water content increased with increasing RH. Stratum corneum water content increased 50% when the temperature was raised from 20 to 35 degrees C at RH below 60%. Temperature dependence decreased with increasing RH until there was essentially no temperature dependence at 90% RH. The conclusion is that temperature changes could significantly affect water content in vivo and pliability of skin at RH below 60%.
Points: The other stretch reflex
Authors: T J Steiner
Journal: BMJ (1984)

known inhibitors of the enzyme-for example, isoniazide.Isoniazide interferes with the ALA- synthase coenzyme, pyridoxal phosphate, and, chronically administered, has a potent inhibitory effect on the hepatic enzyme in guinea pigS.2 3 I know of no trial concerning the effect of the drug in acute porphyria, either clinical or experimental.
Smoke, the Chief Killer — Strategies for Targeting Combustible Tobacco Use
Authors: Michael C. Fiore, Steven A. Schroeder, Timothy B. Baker
Journal: New England Journal of Medicine (2014)

The current landscape of tobacco use presents new challenges and opportunities. Since the net harms of combustible tobacco products dwarf those of other forms of tobacco use, combustible tobacco should be the focus of concerted clinical and public health efforts.
La Lingua Dell'Estremità (The Language of the End)
Authors: Jennifer Best
Journal: Annals of Internal Medicine (2007)

Ad Libitum18 December 2007La Lingua Dell'Estremità (The Language of the End)Jennifer Best, MDJennifer Best, MDFrom Harborview Medical Center, Seattle, WA 98104.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-12-200712180-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In his time, and in my mind's eye, his hair is a bit awry, but he is a starand he wears a cardigan sweater with long sleeves and suede patches at the elbows,fluidly conjugating verbs in chalk at the front of a classroom.His students struggle to follow him, but he is patient.He is a linguist. Master of seven languages.Now he is ninety-six,and the tongue that wrapped adroitly around words like “Vladivostok” and“vouloir c'est pouvoir” and “fremdsprachen”tangles sluggishly with an endotracheal tubeand is mute.Another speaks Russian—his wife.... Author, Article, and Disclosure InformationAffiliations: From Harborview Medical Center, Seattle, WA 98104.Current Author Address: Jennifer Best, MD, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 18 December 2007Volume 147, Issue 12Page: 888KeywordsDopamineElbowElderlyLungsTongue ePublished: 18 December 2007 Issue Published: 18 December 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 1361: Fragment based drug discovery of selective inhibitors of Fibroblast Growth Factor Receptor (FGFR)
Authors: Gordon Saxty, R Akkari, P Angibaud, J Arts, P Benderitter, V Berdini, P Bonnet, A Cleasby, W Embrechts, E Freyne, R Gilissen, P King, J Lacrampe, Y Ligny, A Madin, S Mcclue, L Mevellec, C W. Murray, H Newell, M Page, A Papanikos, T Perera, O Querolle, D C. Rees, S J. Rich, S M. Saalau-Bethell, E Sement, Y Simmonet, M Squires, V Tronel, G A. Ward, M Willems, Wroblowski B, N T. Thompson
Journal: Cancer Research (2011)

Abstract Recent data in a number of tumour types has implicated Fibroblast Growth Factor (FGF) and Fibroblast Growth Factor receptor (FGFR) signalling as being key to the molecular pathology of cancer. A fragment screening campaign was conducted against the tyrosine kinase domain of FGFR1 to detect low molecular weight compounds that bound to the hinge region of the kinase. The screening produced several fragment inhibitors (molecular weight &amp;lt;250 Da) in the micromolar range and their binding modes were confirmed by X-ray crystallography. We selected an imidazo[1,2-a]pyridine fragment that was 120 uM versus FGFR3 in the kinase inhibition bioassay. Subsequently, in the fragments-to-leads stage a detailed structural understanding of the binding interactions between the fragment and its protein kinase target, using X-ray crystallography, led to the identification of a 0.003 uM inhibitor of FGFR3 in the kinase bioassay, with significant selectivity versus VEGFR2 and FLT3. The poster will focus on the description of previously undescribed compounds bearing an imidazo[1,2-a]pyridine core scaffold where selectivity versus other protein kinases, for example FLT3, is obtained using the X-ray crystal structure and structure-based design. In summary we will illustrate how X-ray crystallography and fragment-based drug design (FBDD) can be used to discover compounds with activity in an FGFR driven xenograft model when dosed by the oral route. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1361. doi:10.1158/1538-7445.AM2011-1361
Ontogenetic Alterations in Molecular and Structural Correlates of Dendritic Growth after Developmental Exposure to Polychlorinated Biphenyls
Authors: Pamela J. Lein, Dongren Yang, Adam D. Bachstetter, Hugh A. Tilson, G. Jean Harry, Ronald F. Mervis, Prasada Rao S. Kodavanti
Journal: Environmental Health Perspectives (2007)

ObjectivePerinatal exposure to polychlorinated biphenyls (PCBs) is associated with decreased IQ scores, impaired learning and memory, psychomotor difficulties, and attentional deficits in children. It is postulated that these neuropsychological deficits reflect altered patterns of neuronal connectivity. To test this hypothesis, we examined the effects of developmental PCB exposure on dendritic growth.MethodsRat dams were gavaged from gestational day 6 through postnatal day (PND) 21 with vehicle (corn oil) or the commercial PCB mixture Aroclor 1254 (6 mg/kg/day). Dendritic growth and molecular markers were examined in pups during development.ResultsGolgi analyses of CA1 hippocampal pyramidal neurons and cerebellar Purkinge cells indicated that developmental exposure to PCBs caused a pronounced age-related increase in dendritic growth. Thus, even though dendritic lengths were significantly attenuated in PCB-treated animals at PND22, the rate of growth was accelerated at later ages such that by PND60, dendritic growth was comparable to or even exceeded that observed in vehicle controls. Quantitative reverse transcriptase polymerase chain reaction analyses demonstrated that from PND4 through PND21, PCBs generally increased expression of both spinophilin and RC3/neurogranin mRNA in the hippocampus, cerebellum, and cortex with the most significant increases observed in the cortex.ConclusionsThis study demonstrates that developmental PCB exposure alters the ontogenetic profile of dendritogenesis in critical brain regions, supporting the hypothesis that disruption of neuronal connectivity contributes to neuropsychological deficits seen in exposed children.
CLINICAL SIGNIFICANCE OF TWISTING MOTION ESTIMATED BY 3D SPECKLE TRACKING STRAIN ACUTELY AFTER ONSET OF ST-ELEVATION MYOCARDIAL INFARCTION
Authors: Noriaki Iwahashi, Masaomi Gohbara, Masaaki Konishi, Kengo Tsukahara, Yoshio Tahara, Kiyoshi Hibi, Masami Kosuge, Toshiaki Ebina, Satoshi Umemura, Kazuo Kimura
Journal: Journal of the American College of Cardiology (2014)
Mechanisms of apnea termination in obstructive sleep apnea. Role of chemoreceptor and mechanoreceptor stimuli.
Authors: R J Kimoff, T H Cheong, A E Olha, M Charbonneau, R D Levy, M G Cosio, S B Gottfried
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Previous work from our laboratory has indicated that mechanoreceptor feedback from the respiratory muscles may play an important role in arousal and apnea termination in obstructive sleep apnea (OSA). Other studies have pointed to a prominent role for chemoreceptor stimuli. We postulated that mechanoreceptor stimuli from the respiratory system are the primary determinant of apnea termination, and that chemoreceptor stimuli exert their effect indirectly through stimulation of ventilation and thus proprioceptive feedback. To test this, we measured the diaphragmatic tension-time index (TTdi) during obstructive sleep apneas in seven male subjects with severe untreated OSA. We compared the maximal TTdi values at end-apnea during administration of air, O2, and CO2. We reasoned that if mechanoreceptor stimuli mediate apnea termination, changing the degree of chemoreceptor stimulation during apneas should not alter the level of respiratory effort at end-apnea. O2 administration produced a significant increase in end-apneic arterial oxygen saturation (SaO2) and increased apnea duration. CO2 administration led to an increase in pre- and postapneic end-tidal carbon dioxide pressure (PETCO2), and tended to shorten apneas. However, the mean value for maximal end-apneic TTdi was 0.12 +/- 0.01 (SEM) during room air breathing and was unaltered by O2 (0.12 +/- 0.01) or CO2 (0.11 +/- 0.01) administration. The consistency of end-apneic TTdi values despite the varying chemical drive supports the hypothesis that apnea termination in OSA is mediated by mechanoreceptor feedback from the respiratory system, most likely from the respiratory muscles. The influence of chemoreceptor information may be mediated indirectly through an effect on ventilatory effort.
Presenilins in Alzheimer’s disease and frontotemporal dementia
Authors: Jie Shen
Journal: Molecular Neurodegeneration (2012)

Results Our recent report showed that presenilins regulate synaptic function by modulating ryanodine receptor-mediated calcium release from the ER. To determine how presenilins regulate intracellular calcium signaling in neurons, we performed Ca imaging coupled with electrophysiological and molecular analyses using both acute hippocampal slices of unique presenilin conditional mutant mice and cultured hippocampal neurons, in which presenilins are acutely inactivated with a lentivirus expressing Cre recombinase.
Pulmonary mycobacteriosis in a patient affected by mycosis fungoides: A diagnostic and therapeutic challenge
Authors: R.G. Borroni, U. Bottoni, V. Devirgiliis, V. Panasiti, M. Mancini, M. Curzio, M. Rossi, M. Venditti, M. Martelli, S. Delia, R. Clerico, S. Calvieri
Journal: Journal of Infection (2006)