tbuckley/cabot-search huggingface dataset:
Effects of Age, Sex, and Polycystic Disease on Progressive Bone Disease of Renal Failure
Authors: J. F. Moorhead, G. L. V. Tatler, R. A. Baillod, Z. Varghese, M. R. Wills, S. C. Farrow
Journal: BMJ (1974)

A study of 150 patients undergoing haemodialysis has shown that age had a striking effect on the radiological presentation of renal bone disease, erosions being common in the young and uncommon in older patients and vascular calcification showing opposite trends to this. Men aged 20 to 59 years had a greater tendency to develop erosions than did women in this age range. Examination of a group of 53 patients over a period of five years showed that the half time for the development of vascular calcification was 4.6 years, erosions 26.7 years, and fractures 6.9 years. Nine out of 16 polycystic patients matched for age and sex with 50 controls did not develop erosions and had consistently less vascular calcification than the controls when examined over a six-year period.
Early Experience With Pay-for-Performance
Authors: Meredith B. Rosenthal, Richard G. Frank, Zhonghe Li, Arnold M. Epstein
Journal: JAMA (2005)

The adoption of pay-for-performance mechanisms for quality improvement is growing rapidly. Although there is intense interest in and optimism about pay-for-performance programs, there is little published research on pay-for-performance in health care.To evaluate the impact of a prototypical physician pay-for-performance program on quality of care.We evaluated a natural experiment with pay-for-performance using administrative reports of physician group quality from a large health plan for an intervention group (California physician groups) and a contemporaneous comparison group (Pacific Northwest physician groups). Quality improvement reports were included from October 2001 through April 2004 issued to approximately 300 large physician organizations.Three process measures of clinical quality: cervical cancer screening, mammography, and hemoglobin A1c testing.Improvements in clinical quality scores were as follows: for cervical cancer screening, 5.3% for California vs 1.7% for Pacific Northwest; for mammography, 1.9% vs 0.2%; and for hemoglobin A1c, 2.1% vs 2.1%. Compared with physician groups in the Pacific Northwest, the California network demonstrated greater quality improvement after the pay-for-performance intervention only in cervical cancer screening (a 3.6% difference in improvement [P = .02]). In total, the plan awarded 3.4 million dollars (27% of the amount set aside) in bonus payments between July 2003 and April 2004, the first year of the program. For all 3 measures, physician groups with baseline performance at or above the performance threshold for receipt of a bonus improved the least but garnered the largest share of the bonus payments.Paying clinicians to reach a common, fixed performance target may produce little gain in quality for the money spent and will largely reward those with higher performance at baseline.
Oxygen for Foetal Distress in Domiciliary Midwifery
Authors: T. B. L. Bryan, W. G. Dawson
Journal: BMJ (1958)

obtained, and four hours later was conscious enough to follow moving objects with her eyes.She began speaking on October 31; her condition con- tinued to improve, and she was transferred to the Three Counties Hospital, Arlesey, 11 days after admission, as a voluntary patient.COMMENT This patient was treated with massive doses of bemegride and amiphenazole.Within four days the total dose of bemegride was 14 g. and of amiphenazole 4.2 g.No toxic effects or side-effects were noted.The previous highest dose reported was 6.95 g. of bemegride and 2.08 g. of amiphenazole (Clemmesen, 1956).It is interesting that the only psychic disturbance of those reported by Kjaer- Larsen ( 1956) was amnesia regarding the attempted suicide.Dr. R. J. Russell, assistant psychiatrist, reports: "This woman appeared to be a straightforward case of melan- cholia, and she has responded to E.C.T. in the normal manner.
Genetic heterogeneity of primary familial and congenital polycythemia
Authors: Robert Kralovics, Josef T. Prchal
Journal: American Journal of Hematology (2001)

Primary familial and congenital polycythemia (PFCP) is an inherited disorder of erythroid progenitor cells resulting in elevated erythrocyte mass. Several mutations of the erythropoietin receptor (EPOR) gene have been associated with PFCP, although in a few families the linkage between the EPOR gene and PFCP has been excluded. To examine the role of EPOR mutations in the pathogenesis of PFCP, we studied 43 unrelated PFCP subjects. Erythroid culture data were available in 26 subjects, and in all these subjects, we observed hypersensitivity of erythroid progenitors to erythropoietin (EPO). We screened all EPOR gene exons for mutations using ribonuclease cleavage assay and protein truncation test. We detected five mutations in exon VIII of the EPOR gene, four of which we reported earlier. A new EPOR gene mutation was found (G5959T) that changes codon 425 GAG to a termination codon, resulting in truncation of the EPOR by 84 amino acids. The G5959T mutation was found to segregate with the disease in the affected family and represents another example of a nonsense mutation associated with PFCP. We also report the first intronic mutation (A2706T) of the EPOR gene. The finding of only five disease-causing mutations in our PFCP patient pool of 43 subjects (12%) indicates that EPOR gene mutations are not the major genetic defect associated with PFCP. The hypersensitivity of erythroid progenitors to EPO seen in all examined PFCP subjects suggests a dominant lesion of an as yet unidentified gene either at the level of the EPOR signaling pathway or another erythropoiesis regulating pathway.
Trichostrongylus Infestation in South Persia
Authors: I. S. Stewart
Journal: BMJ (1949)

CEREBRAL NIETASTASIS FROM BRONCHIAL CARCINOMA BRIhRNA 737 MEDICAL JOUR~N.L Radiographs showed that the chest opacity had very consider- ably increased in the past three months, but bronchoscopy remained negative.On March 11 a left pneumonectomy was carried out by Mr. Vernon Thompson.The growth, which was in the hilar region, was massive, but no enlarged mediastinal glands were found, and there was no growth in several hilar glands later sectioned.The tumour was a squamous-celled carcinoma.Convalescence was again uneventful, but in view of the dural adhesions the patient was referred to Dr. Frank Ellis for deep x-irradiation of the region of the cranial defect.No radiation was given to the chest.At the time of writing, 18 months after the removal of his lung, the patient is well, works a full day in his exacting employment, and has no sign of recurrence or of any further metastasis.
Pseudomonas aeruginosa Rash Associated With Whirlpool
Authors: William J. McCausland
Journal: JAMA (1976)

To the Editor.—  I have been somewhat delayed in writing this letter, but I do feel I should respond to an erroneous statement made by the authors of  Pseudomonas aeruginosa Rash Associated with a Whirlpool (235:2205, 1976) regarding the findings of a similar occurrence and investigation that we conducted in 1972. 1 I'm personally acquainted with the authors, and I am sure that it was simply a misinterpretation of our data.  It was stated on page 2206 that A similar outbreak in Minnesota has been described, but in that investigation several pseudomonads were identified from pool surfaces, but none was recovered from pool water. This statement was incorrect. Indeed, in our investigation, pseudomonads were recovered from pool water, as well as from infected skin areas of several of the children who used the whirlpool. Unfortunately, in Table 4 of our article, the source of a culture was simply indicated as
Refinement of the critical region for MCKD1 by detection of transcontinental haplotype sharing
Authors: Matthias T.F. Wolf, Stephanie M. Karle, Stella Schwarz, Mathias Anlauf, Manfred Anlauf, Lisa Glaeser, Sabine Kroiss, Chris Burton, Terry Feest, Edgar Otto, Arno Fuchshuber, Friedhelm Hildebrandt
Journal: Kidney International (2003)
A CASE OF KNOTTED AND IMPACTED URETHRAL CATHETER
Authors: M. J. Fox
Journal: JAMA (1922)

D. S., a white man, aged 22, entered Milwaukee County Hospital complaining of an impaction of a self-inserted, soft rubber urethral catheter. The family history was unimportant. The patient denied any venereal disease or unusual sexual practices. He stated that on one occasion, one year before, for no apparent reason, he found himself unable to void, and was relieved by catheterization by a physician. There had been no subsequent trouble until the present illness. Aug. 23, 1922, without apparent cause, he was again unable to void, and after a continence of twelve hours, the discomfort of a distended bladder impelled him to insert a rubber tubing and empty the bladder. He could not withdraw the rubber tube. It seemed solidly fixed, and the slightest traction resulted in agonizing pain in the region of the bladder neck. Becoming alarmed, he consulted a physician, who made several attempts to withdraw the tube,
Single Resting hsTnT Level Predicts Abnormal Myocardial Stress Test in Acute Chest Pain Patients With Normal Initial Standard Troponin
Authors: Waleed Ahmed, Christopher L. Schlett, Shanmugam Uthamalingam, Quynh A. Truong, Wolfgang Koenig, Ian S. Rogers, Ron Blankstein, John T. Nagurney, Ahmed Tawakol, James L. Januzzi, Udo Hoffmann
Journal: JACC. Cardiovascular imaging (2013)
Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector–transduced CD34+ cells
Authors: Yoo-Jin Kim, Yoon-Sang Kim, Andre Larochelle, Gabriel Renaud, Tyra G. Wolfsberg, Rima Adler, Robert E. Donahue, Peiman Hematti, Bum-Kee Hong, Jean Roayaei, Keiko Akagi, Janice M. Riberdy, Arthur W. Nienhuis, Cynthia E. Dunbar, Derek A. Persons
Journal: Blood (2009)
Rationale and design of the Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure (EMPHASIS‐HF)
Authors: Faiez Zannad, John J.V. McMurray, Helmut Drexler, Henry Krum, Dirk J. van Veldhuisen, Karl Swedberg, Harry Shi, John Vincent, Bertram Pitt
Journal: European Journal of Heart Failure (2010)
IgA and IgG anti-ragweed antibodies in nasal secretions. Quantitative measurements of antibodies and correlation with inhibition of histamine release.
Authors: T A Platts-Mills, R K von Maur, K Ishizaka, P S Norman, L M Lichtenstein
Journal: Journal of Clinical Investigation (1976)

Total secretory IgA and specific anti-antigen E (AgE) antibodies (ab) in the IgA and IgG classes were measured in concentrated nasal washings from ragweed allergic and normal individuals by antigen binding or anti-alpha-radioimmunoassays. Virtually all the allergic patients had significant IgA (45/49) and IgG (46/49) ab to AgE in their nasal washings. By contrast, washings from most normal persons contained no measurable IgA (13/15) ab or IgG (13/15) ab to AgE. The total IgA levels in allergic washings were not significantly different from those in normal washings and they were used to standardize the ab measurements. Parenteral immunotherapy with ragweed extract increased specific nasal IgA ab from 10.6 +/- 2.7 (SEM) to 39.0 +/- 8.7 ng AgE bound/mg IgA and IgG ab from 17.2 +/- 2.6 to 65.1 +/- 7.4 ng AgE bound/mg IgA (P less than 0.001 for both classes). The ratio of IgA:IgG ab was not affected by therapy, and for treated patients, there was no correlation (rs + 0.32, P greater than 0.1) between nasal IgG ab and serum IgG ab. These results suggest that at least part of the nasal IgG ab is produced locally. Blocking activity in the nasal washings was measured by inhibition of histamine release and was found to correlate directly (rs + 0.85, P less than 0.001) with binding activity for AgE. Some washings from normal persons caused slight inhibition of histamine release but others caused enhancement. Nasal washings were fractionated by passage over Sephadex G-200. Inhibition of histamine release by dilutions of the IgA-rich and IgG-rich fractions correlated well with binding activity in these fractions. None of these results support the hypothesis that allergic individuals are deficient in secretory IgA or secretory ab responses. These results, however, are in keeping with the theory that hay fever occurs in a high-responder population which is genetically able to respond to low doses of inhalant antigens.
Divergent effects of methotrexate on the clonal growth of T and B lymphocytes and synovial adherent cells from patients with rheumatoid arthritis.
Authors: A Nakajima, M Hakoda, H Yamanaka, N Kamatani, S Kashiwazaki
Journal: Annals of the Rheumatic Diseases (1996)

OBJECTIVE: To define the mechanisms whereby methotrexate (MTX) manifests its effects in patients with rheumatoid arthritis. METHODS: T and B cells from peripheral blood and rheumatoid synovial tissues, synovial adherent cells, and the human fibrosarcoma cell line HT1080 and its mutant (defective in an enzyme in the nucleotide salvage pathway) were tested for clonal growth when cultured with MTX. Normal human fibroblasts and those with a deficiency in a salvage pathway were cultured with MTX in the presence or absence of purine and pyrimidine bases. RESULTS: Clonal growth of T and B cells, but not synovial cells, was inhibited by clinically relevant concentrations of MTX. Slowly proliferating fibroblast lines were resistant to MTX, whereas their rapidly proliferating counterparts were not. However, mutant fibroblast lines deficient in a salvage pathway were sensitive to MTX despite slow proliferation. Similarly, while skin fibroblasts were resistant to MTX, germline mutant fibroblasts deficient in a salvage pathway were sensitive to small concentrations of MTX. CONCLUSION: T and B lymphocytes, but not synovial cells, may be the target of MTX in vivo. Resistance to MTX may be associated with slow proliferation and the ability to synthesise nucleotides via salvage pathways. MTX can inhibit proliferation of even slowly growing cells by restricting the supply of nucleotides obtained via a salvage pathway, by removal of purine and pyrimidine bases, or by inducing a deficiency in a salvage pathway. It may be possible to manipulate the therapeutic effect of MTX by adjusting the amounts of purines and pyrimidines available to the cells in vivo.
Retrospective Serologic Diagnosis of Hemolytic Transfusion Reactions
Authors: Edmond J. Yunis, Newell Ziegler, Sandra Benson
Journal: JAMA (1964)

The measurement of antibody titers at different intervals following blood transfusion reactions provides a useful method of investigating blood incompatibility in patients when the pretransfusion blood samples of the donor and recipient are not available. The anamnestic response of an iso-antibody following transfusion is presumptive evidence of a blood transfusion reaction due to blood group incompatibility.
956 MIR29 TARGETS THE POTENT PROFIBROGENIC GROWTH FACTORS SUCH AS IGF-I AS WELL AS TWO MEMBERS OF THE VEGF/PDGF FAMILY
Authors: M. Kwiecinski, I. Strack, N. Elfimova, A. Noetel, U. Drebber, U. Töx, H.P. Dienes, M. Odenthal
Journal: Journal of Hepatology (2010)
Cimetidine in acute upper gastrointestinal bleeding.
Authors: S M Siddiqi, G Tildesley, P T Pickens, R A McNay
Journal: BMJ (1979)

Premenstrual tensionSIR,-Paraphrasing the opening sentence of the leading article, "Premenstrual tension" (27 January, p 212), I would say that there is nothing pleasant about inaccuracies, especially when they appear in such a well-written, well- documented, up-to-date article.You cite two studies that "have failed to confirm any rise in prolactin concentrations in patients with premenstrual tension."This statement is incorrect, because Andersch et all clearly report: "In patients with PMT prolactin levels were significantly higher premenstrually compared to levels during the follicular phase.In the control group no such increase was observed."A careful examination of the second article cited2 shows a very vague definition, selection, and mental evaluation of their sample group.According to table II in that article, the average severity of mental complaints among the group was 1 01-that is, slight-and they did not mention any control group for the drug-free cycle.None the less, more than one variable seems to be implicated in the cause of the premenstrual tension syndrome, and, concerning the accumulating data, one may assume that we are dealing with a group of syndromes which may be caused by an imbalance between several factors affecting the central (and possibly CNS peripheral) nervous system.A better understanding of the aetiology of these syndromes is unlikely before a precise definition is formulated.
Question of Priority.
Authors: L. Pierce Clark
Journal: JAMA (1899)

Craig Colony, Sonyea, N. Y., April 18, 1899. <h3>To the Editor:</h3> —Apropos to your editorial on "A Question of Priority" (videJournal, April 15), I desire to submit the following comments: That science should know no national limitations is often quoted, but it has not become as yet a practical fact. To one having occasion to look up the bibliography of subjects in medical science, they are often struck with the extreme limitations of many so-called reviews in the German, French and English publications. This state of affairs can not be from a lack of expressed desire on the part of such reviews, as they continually proclaim that the breadth of their horizon is not bounded by the language of their publication. Neither can it be because of lack of knowledge of languages other than their own. Much less can it depend upon a lack of worthy matter to incorporate
(12) Thiazide-induced photosensitivity, the use of bumetanide as alternative therapy: in vitro and in vivo studies
Authors: G. Lowe, E.M. Walker, B.E. Johnson, J. Ferguson
Journal: British Journal of Dermatology (1989)

Journal Article (12) Thiazide‐induced photosensitivity, the use of bumetanide as alternative therapy: in vitro and in vivo studies Get access G. Lowe, G. Lowe Photobiology Unit, University of Dundee Search for other works by this author on: Oxford Academic Google Scholar E.M. Walker, E.M. Walker Photobiology Unit, University of Dundee Search for other works by this author on: Oxford Academic Google Scholar B.E. Johnson, B.E. Johnson Photobiology Unit, University of Dundee Search for other works by this author on: Oxford Academic Google Scholar J. Ferguson J. Ferguson Photobiology Unit, University of Dundee Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 121, Issue s34, 1 July 1989, Page 58, https://doi.org/10.1111/j.1365-2133.1989.tb05963.x Published: 01 July 1989
Achieving Health Care Reform — How Physicians Can Help
Authors: Elliott S. Fisher, Donald M. Berwick, Karen Davis
Journal: New England Journal of Medicine (2009)

This year, we have the best chance in a generation of enacting legislation worthy of being called health care reform and of setting the United States on the path to high-quality, affordable health care for all Americans. The recent commitment by several major stakeholders — including the American Medical Association — to slowing the growth of health care spending is a promising development. But the controversy about whether the organizations actually agreed to a 1.5-percentage-point reduction in annual spending growth is just one indication that success is still far from assured.Two threats in particular put reform at risk: conflicting . . .
The Role of Surfactant Protein A in Bleomycin-induced Acute Lung Injury
Authors: Hisatsugu Goto, Julie G. Ledford, Sambuddho Mukherjee, Paul W. Noble, Kristi L. Williams, Jo Rae Wright
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Surfactant protein A (SP-A) is a collectin family member that has multiple immunomodulatory roles in lung host defense. SP-A levels are altered in the bronchoalveolar lavage (BAL) fluid and serum of patients with acute lung injury and acute respiratory distress syndrome, suggesting the importance of SP-A in the pathogenesis of acute lung injury.Investigate the role of SP-A in the murine model of noninfectious lung injury induced by bleomycin treatment.Wild-type (WT) or SP-A deficient (SP-A(-/-)) mice were challenged with bleomycin, and various indices of lung injury were analyzed.On challenge with bleomycin, SP-A(-/-) mice had a decreased survival rate as compared with WT mice. SP-A(-/-) mice had a higher degree of neutrophil-dominant cell recruitment and the expression of the inflammatory cytokines in BAL fluid than did WT mice. In addition, SP-A(-/-) mice had increased lung edema as assessed by the increased levels of intravenously injected Evans blue dye leaking into the lungs. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling and active caspase-3 staining suggested the increased apoptosis in the lung sections from SP-A(-/-) mice challenged with bleomycin. SP-A also specifically reduced bleomycin-induced apoptosis in mouse lung epithelial 12 cells in vitro. Moreover, intratracheal administration of exogenous SP-A rescued the phenotype of SP-A(-/-) mice in vivo.These data suggest that SP-A plays important roles in modulating inflammation, apoptosis, and epithelial integrity in the lung in response to acute noninfectious challenges.
A New Operation for Repairing Aortic Arch Atresia in Infancy
Authors: HOWARD D. SIRAK, MEHDI RESSALLAT, DON M. HOSIER, ALFRED A. DELORIMIER
Journal: Circulation (1968)

Aortic arch atresia is a comparatively rare congenital anomaly that commonly produces heart failure and death in early infancy. A new operative procedure is described which is applicable to type I, where the atresia lies distal to the left subclavian artery. It provides a lumen that is equal to the descending thoracic aorta by using the conjoined orifices of the left subclavian and common carotid arteries for anastomosis to the distal thoracic aorta. The chief advantage of this method is that it not only provides a vascular bridge with a lumen equal to the distal thoracic aorta, but also assures normal growth potential.
Pronounced cerebellar features in legionnaires' disease.
Authors: M R Maskill, E C Jordan
Journal: BMJ (1981)

in Orientals), or myasthenia gravis.4Initially, bulbar muscle dysfunction was believed to complicate a pre-existent, proximal skeletal muscle weakness.Kammer and Hamilton2 and other workers showed that hyperthyroid patients without evidence of chronic myopathy sometimes presented with dysphagia.Such patients complained of dysphagia, nasal regurgitation of solids and liquids, voice changes, diplopia, facial paresis, and diminished tongue strength.Nasogastric feeding and intensive physiotherapy to protect the airway was sometimes required.This patient presented acutely and had all of these symptoms but, unlike similar patients, required artificial respiration for six weeks because of complete paralysis of laryngeal and intercostal muscles and inability to swallow.This case shows that hyperthyroid patients without chronic myopathy may present with a disabling non-myasthenic bulbar myopathy that may require intubation or tracheostomy because of the acute bulbar paralysis.
Mutations of polymerase, precore and core promoter gene in hepatitis B virus during 5-year lamivudine therapy
Authors: Fumitaka Suzuki, Yoshiyuki Suzuki, Akihito Tsubota, Norio Akuta, Takashi Someya, Masahiro Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
Journal: Journal of Hepatology (2002)