tbuckley/cabot-search huggingface dataset:
Angiotensin-Converting Enzyme Inhibitors in Nondiabetic Renal Disease
Authors: Romulo E. Colindres
Journal: Annals of Internal Medicine (1998)

Letters15 April 1998Angiotensin-Converting Enzyme Inhibitors in Nondiabetic Renal DiseaseRomulo E. Colindres, MD and Abhijik V. Kshirsagar, MDRomulo E. Colindres, MDUniversity of North Carolina at Chapel Hill; Chapel Hill, NC 27599Search for more papers by this author and Abhijik V. Kshirsagar, MDUniversity of North Carolina at Chapel Hill; Chapel Hill, NC 27599Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-8-199804150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Giatras and colleagues recently conducted a thorough meta-analysis of the influence of angiotensin-converting enzyme (ACE) inhibitors in slowing the progression of nondiabetic renal disease [1]. They found that in the aggregate, ACE inhibitors reduce the risk for end-stage renal disease. The pooled relative risk of ACE inhibitors for this disease compared with control medications is 0.70 (95% CI, 0.51 to 0.97). The influence of blood pressure (initial and change at follow-up) on the observed effects could not be precisely assessed.The study has important methodologic strengths that increase the validity of the findings. First, the authors included ...References1. Giatras I, Lau J, Levey AS. Effect of angiotensin-converting enzyme inhibitors on the progression of nondiabetic renal disease: a meta-analysis of randomized trials. Ann Intern Med. 1997; 127:337-45. Google Scholar2. Maschio G, Alberti D, Janin G, Locatelli F, Mann JF, Motolese M, et al. Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. N Engl J Med. 1996; 334:939-45. Google Scholar3. LeLorier J, Gregoire G, Benhaddad A, Lapierre J, Derderian F. Discrepancies between meta-analyses and subsequent large randomized, controlled trials. N Engl J Med. 1997; 337:536-42. Google Scholar4. Capparelleri JC, Ioannidis JP, Schmid CH, de Ferranti SD, Aubert M, Chalmers TC, et al. Large trials vs meta-analysis of smaller trials: how do their results compare? JAMA. 1996; 276:332-8. Google Scholar5. Thompson SG. Why sources of heterogeneity in meta-analysis should be investigated. BMJ. 1994; 309:1351-5. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of North Carolina at Chapel Hill; Chapel Hill, NC 27599 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1998Volume 128, Issue 8Page: 694KeywordsACE inhibitorsAngiotensin converting enzymeAngiotensin converting enzyme inhibitorBlood pressureClinical trialsRelative riskRenal diseasesRenal failure ePublished: 15 August 2000 Issue Published: 15 April 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Chronic longitudinal NSAID-related ulcer of the colon (“colon single-stripe sign”) in Munchhausen syndrome
Authors: C. Hogenauer, A. Eherer, J. Pfeifer, C. Langner
Journal: Endoscopy (2008)

A 62-year-old woman presented with chronic gastrointestinal bleeding. Colonoscopy showed a longitudinal ulcer extending from the ascending to the transverse colon ([Fig. 1 ] a). Biopsies taken from the ulcer ruled out malignancy and inflammatory bowel disease. Despite extensive diagnostic workup, including angiography and CT scan, the cause of the ulcer remained unclear. The patient denied taking nonsteroidal anti-inflammatory drugs (NSAIDs). The patient received empiric treatment with antibiotics, steroids, and mesalamine (5-aminosalicylic acid, 5-ASA), but the ulcer persisted for 6 months on repeated endoscopy. During this period the patient required the transfusion of 17 units of red blood cells. Repeated gastrointestinal hemorrhage finally prompted right hemicolectomy.
SOME PROPHYLACTIC MEASURES CAUSING INCREASED NEUROMUSCULAR ABILITY IN THE SPORTSMAN
Authors: M. D. Azatjan
Journal: British Journal of Sports Medicine (1973)

t is well-known that switching over from one kind of activity to another, can develop the total productivity of work with less fatigue, and the nature of this phenomena has been understood only recently.Many experiments have shown that the phenomena of switching over to another activity is effective only in prolonged sporting exercises; for instance, momentary back-pedalling on a bicycle while freewheeling removes early fatigue and increases work output.A rational explanation of this phenomena is not quite clear, but experiments suggest that functions of muscles statically contracting are changed as well, leading to withdrawal of fatigue.Afterwards when switching over to active work, the motor neurones and muscle fibres that were inactive, begin to work, but the duration of the active process may vary during each cycle.For example, if one recorded the biopotential of muscles of the lower extremities: the quadriceps femoris, biceps femoris, tibialis anterior and gastrocnemius, one can see, that in the last case the correlation between the period of activation and the period of silence of each group is quite different.While the usual forward pedalling biceps femoris works through 1900, but during back-pedalling it only works through 1600.In this case when we change the direction of pedalling that is the direction of the muscle, work diminishes; that means that the muscle is in better condition for recovery.Life of modern men becomes more and more intensive.But this intensification causes neuro-psychical excitement while physically man is relatively in the condition of immobility.Under these conditions the transfer of different actions for the same muscles has the desired effect for raising the total and special ability of the function of man.
Electrophysiologic delineation of the intraventricular His bundle in two patients with endocardial cushion type of ventricular septal defect.
Authors: M Dick, D M Behrendt, K E Jochim, A R Castaneda
Journal: Circulation (1981)

Two patients who had an endocardial cushion type of ventricular septal defect underwent electrophysiologic studies for detection of specialized conduction tissue during operative repair. In one patient, with an inferior leftward frontal plane QRS axis on the ECG, we recorded an intraventricular His bundle electrograms from both the anterosuperior and posteroinferior margins of the defect, suggesting dual atrioventricular conduction tracts (branching intraventricular His bundle). These anatomic and electrophysiologic findings may account for the more normally oriented QRS frontal plane axis on the surface ECG of both of these patients and support the hypothesis that the changes observed on the ECGs of patients with the various forms of endocardial cushion defect can be explained by alterations in the anatomic configuration of the specialized atrioventricular conduction tissue.
Market Reforms for the Health Care System
Authors: Ken S. Honbo
Journal: JAMA (1996)

To the Editor.  —Dr Ginzberg 1 makes two fundamental errors in his recent assessment of our health care system, which in turn, make it impossible to arrive at a correct solution.  First, Ginzberg incorrectly assumes that the health insurance market has been a free market. Quite the opposite is true. Since World War II, the private health insurance industry has been largely an employer-based system in which the consumer is out of the loop. Rather than having the consumer choose his or her own insurance policy, his or her employer has been the one to do so. This approach arose out of the wage and price controls of the 1940s and is really a way to give a worker nontaxable income (by calling it a benefit instead). It is not unexpected that the bureaucratic tinkering of the 1940s has led to the insurance crisis of today. One solution to the
Resource implications of cancelled operations
Authors: D L McWhinnie, J A Michaels, J Collin, P J Morris
Journal: BMJ (1994)

Harrison differentiate between somatoform pain disorder and the simple adoption of the sick role by those who are aware that it may be to their advantage to complain?Finally, a plaintiffs failure to return to work after the settlement of litigation does not neces- sarily mean that he or she is psychologically sick.It may merely mean that, with the present level of unemployment and the difference between invalidity benefit and unemployment benefit, the incentive to return to work is low.All that the person has to do is to go on complaining: with the support of a psychiatrist who diagnoses somato- form pain disorder, the prospects for the future are rosy.
Cancer and the Peutz-Jeghers syndrome.
Authors: A D Spigelman, V Murday, R K Phillips
Journal: Gut (1989)

Among 72 patients with the Peutz-Jeghers syndrome malignant tumours have developed in 16 (22%) of whom all but one have died. There were nine gastrointestinal and seven nongastrointestinal tumours. The relative risks of death from gastrointestinal cancer and all cancers were 13 (95% CI 2.7-38.1) and 9 (95% CI 4.2-17.3) respectively. The chance of dying of cancer by the age of 57 was 48%. There is evidence for a hamartoma/carcinoma sequence in the Peutz-Jeghers syndrome, suggesting that the gene locus involved is relevant to the development of malignancy in general.
Electrocardiographic consequences of cardiac iron overload in thalassemia major
Authors: Jon Detterich, Leila Noetzli, Fred Dorey, Yaniv Bar‐Cohen, Paul Harmatz, Thomas Coates, John Wood
Journal: American Journal of Hematology (2011)

Iron cardiomyopathy is a leading cause of death in transfusion-dependent thalassemia major (TM) patients and MRI (T2*) can recognize preclinical cardiac iron overload, but, is unavailable to many centers. We evaluated the ability of 12-lead electrocardiography to predict cardiac iron loading in TM. 12-lead electrocardiogram and cardiac T2* measurements were performed prospectively, with a detectable cardiac iron cutoff of T2*less than 20 ms. Patients with and without cardiac iron were compared using two-sample statistics and against population norms using age and gender-matched Z-scores. 45/78 patients had detectable cardiac iron. Patients having cardiac iron were older and more likely female but had comparable liver iron burdens and serum ferritin. Increased heart rate (HR) and prolonged corrected QT interval (QT(c)) were present, regardless of cardiac iron status. Repolarization abnormalities were the strongest predictors of cardiac iron, including QT/QT(c) prolongation, left shift of T-wave axis, and interpretation of ST/T-wave morphology. Recursive partitioning of the data for females using T-axis and HR and for males using QT, HR, and T-axis produced algorithms with AUROC's of 88.3 and 87.1, respectively. Bradycardia and repolarization abnormalities on 12-lead electrocardiography were the most specific markers for cardiac iron in thalassemia major. Changes in these variables may be helpful to stratify cardiac risk when cardiac MRI is unavailable. However, diagnostic algorithms need to be vetted on larger and more diverse patient populations and longitudinal studies are necessary to determine reversibility of the observed abnormalities.
ST-SEGMENT DEPRESSION IN LEAD AVR STRONGLY PREDICTS ADVERSE OUTCOMES IN PATIENTS WITH ANTEROLATERAL ST-SEGMENT ELEVATION ACUTE MYOCARDIAL INFARCTION
Authors: Masami Kosuge, Toshiaki Ebina, Kiyoshi Hibi, Noriaki Iwahashi, Kengo Tsukahara, Nobuhiko Maejima, Mitsuaki Endo, Satoshi Morita, Toshiyuki Ishikawa, Kazuaki Uchino, Satoshi Umemura, Kazuo Kimura
Journal: Journal of the American College of Cardiology (2012)
Lakhichand Dhondiram Munot
Authors: K M Bohara
Journal: BMJ (2002)

Editor who raised the standards and status of the British Journal of Surgery; director of surgery in Bristol who tried to mediate as concerns about paediatric heart surgery emerged John Farndon, professor and head of surgery in Bristol, who died from a heart attack on 6 February, had a gift for medical editing and was an incisive referee.As editor of the British Journal of Surgery from 1992, he had an eye for the best material, putting together a good journal every month and moving it up the international league table until it was second only to Annals of Surgery.He chose papers that would be widely cited, increased the number of randomised controlled trials, and cut back on case reports.He was firm, fair, and strong minded.In January he stepped down as editor and was, as chairman of the British Journal of Surgery Society, to have furthered the journal's development.He wrote and edited textbooks on endocrine and breast surgery, operative surgery, and a guidebook for house surgeons.An excellent operating surgeon, his main interest was in his endocrine work, specialising in thyroid and parathyroid surgery.He improved the way in which patients with phaeochromocytoma were prepared for surgery by characterising the way in which these tumours released their hormones.He made important contributions to our understanding of the cellular biology of breast cancer, characterising those patients who would and would not respond to hormone therapy.
Sudanophilic Diffuse Sclerosis ("Schilder's Disease") with Ictal Onset
Authors: M. Newman, W. H. McMenemey
Journal: BMJ (1960)

<h3>Abstract</h3> High diversity in tropical compared to temperate regions has long intrigued ecologists. Terrestrial arthropods are among the most speciose orders in tropical rainforests. Previous studies show that arthropod herbivores account for much tropical diversity, yet differences in diversity of arthropod predators between tropical and temperate systems have not been quantified. Here, we present the first standardized tropical-temperate forest comparison of species richness and evenness for understory spiders, a dominant and mega-diverse taxa of generalist predators. Species richness was 13-82 times higher in tropical vs. temperate forests. Evenness was also higher with tropical assemblages having 12-55 times more common and 10-40 times more dominant species. By contrast, proportion of rare species were only up to two times greater than that of temperate measurements. These differences in diversity far surpass previous estimates, and exceed tropical-temperate difference for herbivorous taxa. Thus, the extreme diversity of arthropod predators is associated not only with the higher diversity of prey in tropical vs. temperate ecosystems, but probably also with increased diet breadth of understory spiders in the tropics. This work contradicts the widely accepted hypothesis that tropical diversity is associated with more specialization of predators.
Pneumococcal Vaccination and Cardiovascular Events in Men
Authors: Janusz Kaczorowski
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Total body surface potential mapping during exercise: QRS-T-wave changes in normal young adults.
Authors: W T Miller, M S Spach, R B Warren
Journal: Circulation (1980)

Total body surface potential distributions were recorded from 20 normal young adults, 20-35 years old, during multistage maximal exercise testing on a bicycle ergometer. Using a system for measuring total body surface potential distributions from measurements at 24 locations, high-quality potential maps were obtained during exercise without requiring wave form averaging or special modes of exercise. Serial maps recorded at 1-msec intervals throughout QRS-T during exercise and during recovery from exercise were compared with corresponding maps recorded with the subjects at rest. During and after exercise, consistent changes appeared in the map patterns during early QRS and the ST segment and in the magnitude of the T-wave potentials. Increases in QRS duration (0-10 msec) also appeared during exercise. The changes in map patterns during early QRS in exercise strongly suggested changes in the initial sequence of activation in the ventricles. The results demonstrate the importance of analyses of total body surface potential distributions in understanding ECG changes during exercise.
RhoA and Rac1 GTPases play major and differential roles in stromal cell–derived factor-1–induced cell adhesion and chemotaxis in multiple myeloma
Authors: Abdel Kareem Azab, Feda Azab, Simona Blotta, Costas M. Pitsillides, Brian Thompson, Judith M. Runnels, Aldo M. Roccaro, Hai T. Ngo, Molly R. Melhem, Antonio Sacco, Xiaoying Jia, Kenneth C. Anderson, Charles P. Lin, Barrett J. Rollins, Irene M. Ghobrial
Journal: Blood (2009)
Are Tumor Exposure and Anatomical Resection Antithetical during Surgery for Hepatocellular Carcinoma? A Critical Review
Authors: Guido Torzilli, Matteo Donadon, Matteo Cimino
Journal: Liver Cancer (2012)

Hepatic resection is the most potentially curative local therapy for patients with hepatocelluar carcinoma (HCC). However, the high rate of postoperative recurrence, 50–70% at 3 years, remains a major concern. Such recurrences usually occur in the liver owing to the high propensity of HCC to invade the portal vein branches and the underlying liver cirrhosis, which is the ideal background for HCC development. Two pivotal surgical techniques are commonly used to reduce such recurrences: anatomical resection (AR) and achievement of negative margins. However, controversies exist about the definition of anatomical resection and the requisite width of negative margins. Consequently, a consensus on these issues is far from being achieved in the specialized surgical community. Review of the literature and author's discernment support AR for HCC larger than 2cm, and tumor exposure when the tumor is in contact with major vessels. Therefore, tumor exposure is not a contradiction to an AR properly carried out.
Digital immunohistochemistry analysis of intratumoral immune infiltrates in prostate cancer patients treated with intraprostatic/systemic PSA-TRICOM vaccine
Authors: Benedetto Farsaci, Caroline Jochems, Italia Grenga, Renee N Donahue, James L Gulley, Christopher R Heery, Ravi A Madan, Jeffrey Schlom
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Preclinical studies have demonstrated that intraprostatic/intratumoral (IT) administration of vaccine in combination with systemic vaccination (SC) may improve antitumor efficacy. In this study we assessed the differential effects of IT/SC vaccination in peripheral blood
Generic Terminology and the Cost of Drugs
Authors: Dale G. Friend
Journal: JAMA (1969)

In recent years, a great deal of interest has arisen in belief of some that by using generic terminology in all prescription writing, a distinct saving in the cost of drugs to patients will result. In several Senate hearings and in the public utterances by the various legislators and union executives, it is obvious that they, as well as many of the lay public and some physicians, feel that use of generic names for prescription drugs will lead to a distinct lowering in the price of drugs to the patient. Because of the wide interest in this problem, we will attempt to provide various views and some thoughts on issues involved from the viewpoints of the general public, a member of a state legislature, physicians, and pharmacists. <h3>The Public's View</h3> Drug prices are of great concern to the general public in view of the fact that every citizen, whether ill
HLA-haploidentical bone marrow transplantation with posttransplant cyclophosphamide expands the donor pool for patients with sickle cell disease
Authors: Javier Bolaños-Meade, Ephraim J. Fuchs, Leo Luznik, Sophie M. Lanzkron, Christopher J. Gamper, Richard J. Jones, Robert A. Brodsky
Journal: Blood (2012)
STUDIES ON THE CIRCULATORY CHANGES IN THE DOG PRODUCED BY ENDOTOXIN FROM GRAM-NEGATIVE MICROORGANISMS
Authors: Max H. Well, Lloyd D. MacLean, Maurice B. Visscher, Wesley W. Spink
Journal: Journal of Clinical Investigation (1956)

A clinical problem of increasing magnitude is the occurrence of hypotension in patients with bacteremia associated with the liberation of endotoxin from gram-negative microorganisms (1-3). Although the local vascular effects of endotoxin have been extensively studied in animals, particularly with reference to necrotizing effects on tumors (4, 5) and the Schwartzman reaction (6, 7), the hemodynamic alterations produced by these bacterial products remain unexplained. Endotoxins constitute a group of similar chemical substances identified as protein-polysaccharide complexes (8). In the course of a series of investigations reported elsewhere (9, 10), it was found that the pattern of the shock and the pathological changes in the gastrointestinal tract produced by the intravenous injection of endotoxins derived frotn Brucella melitensis, Escherichia coli, Serratia marcescens 1 and Salmonella typhosa 1
Identification of Bloodstains — I
Authors: Joseph T. Walker
Journal: New England Journal of Medicine (1949)

IDENTIFICATION OF BLOODSTAINS — IThere are few types of evidence that occur with greater regularity at the scenes of crimes of violence and bear implications of greater evidential importance than bloodstains. Their recognition and characterization serve to localize the scene of the crime, aid in determining the manner in which it was committed and, if circumstances are favorable, help to identify the perpetrator. It is therefore valuable to review current methods of blood identification and their application to legal medicine.The most sensitive tests for blood are those which make use of its catalytic activity in enhancing the oxidation . . .