tbuckley/cabot-search huggingface dataset:
Pediatric Faculty Diversity
Authors: Leslie R. Walker, F. Bruder Stapleton
Journal: JAMA Pediatrics (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Agranulocytosis Induced by Dipyrone, a Hazardous Antipyretic and Analgesic
Authors: Charles M. Huguley
Journal: JAMA (1964)

AN INCREASING NUMBER of reports of agranulocytosis associated with dipyrone are being received by the American Medical Association's Registry on Adverse Reactions. Between 1955 and 1959 only ten cases of leukopenia associated with this drug had been reported to the Registry from the United States, and none of these were in children. Since 1960, reports of 18 cases have been received, seven of them in children. Thirty-six percent of these patients have died. Since it is probable that many more cases of agranulocytosis occur than are reported to the Registry, these data are a cause for concern. During the same period there has been a striking increase in the use of dipyrone. Much of the dipyrone used in this country is imported; domestic production and sales figures are not available, but US Tariff Commission figures show that imports increased from none in 1958, to 220 lb in 1959; 7,164 lb
Release of immunoreactive somatostatin from the pancreas in response to glucose, amino acids, pancreozymin-cholecystokinin, and tolbutamide.
Authors: E Ipp, R E Dobbs, A Arimura, W Vale, V Harris, R H Unger
Journal: Journal of Clinical Investigation (1977)

The effects of glucose, amino acids, pancreozymin-cholecystokinin, and tolbutamide upon the release of immunoreactive somatostatin (IRS) from the isolated perfused pancreas were studied. In seven experiments in which glucose was perfused either at a concentration of 100 or 350 mg/dl or at 25 mg/dl, IRS levels were significantly greater at the higher glucose concentrations. In three dose-response experiments in which the perfusing glucose concentration was increased at 30-min intervals from an initial concentration of 25 mg/dl to a final concentration of 300 mg/dl, progressive increases in IRS release were noted at glucose concentrations of 100 mg/dl and above. Perfusion of a 20 mM mixture of 10 amino acids also elicited a prompt and significant biphasic IRS rise in each of six experiments. In five experiments, 20 mM leucine evoked a similar response in mean IRS. Perfusion with 0.075 Ivy U/ml of pancreozymin-cholecystokinin, with or without the presence of a 1 mM 10-amino acid mixture, elicited a prompt rise in IRS with a pattern resembling that of insulin in a total of six experiments. Tolbutamide (0.75 mg/min) also stimulated IRS release in five of six challenges. The IRS responses to nutrients and to pancreozymin and their similarity to the insulin responses raise the possibility that, like insulin, pancreatic somatostatin may have an endocrine role related to nutrient homeostasis.
THE EFFECTS OF SPLENECTOMY UPON THE CELL CONTENT OF THE THORACIC DUCT LYMPH IN THE DOG, AND ITS RELATION TO THE ACTION OF PILOCARPIN
Authors: Robert L. Dixon
Journal: The Journal of Experimental Medicine (1912)

1. Splenectomy in dogs results in an immediate increase of cells in the thoracic duct lymph, due to the manipulation involved in the operation. This increase is soon followed by a low cell count, attributable to the removal of an important source of the cells under consideration. Several months after the operation, a normal cell count is reëstablished, due probably to a readjustment of activity on the part of other cell-forming tissues. 2. Pilocarpin injections after splenectomy result in an increase of cells, attributable to an increased activity of the respiratory organs and of the intestine. 3. After the injection of pilocarpin, splenectomy may increase the cell count, but it causes a decrease sooner than in cases of pilocarpin injection not followed by splenectomy.
The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation
Authors: Bihui H. Ye, Giorgio Cattoretti, Qiong Shen, Jiandong Zhang, Nicola Hawe, Rick de Waard, Cynthia Leung, Mahyar Nouri-Shirazi, Attilio Orazi, R.S.K. Chaganti, Paul Rothman, Alan M. Stall, Pier-Paolo Pandolfi, Riccardo Dalla-Favera
Journal: Nature Genetics (1997)
Abstract 2032: TGF-β differentiates immortalized pancreatic epithelial cells to form duct architecture in 3D culture
Authors: Takashi Yamaguchi, Sanae Ikehara, Yuzuru Ikehara
Journal: Cancer Research (2014)

Abstract A genetically engineered mouse (GEM) strain T26 having a transgene “CAG-loxP-βgeo-pA-loxP-SV40 tsA58 large T antigen (=tsTAg)-pA” was created by us, which expressed tsTAg in cells Cre/loxP recombination occurred. In a previous study, T26; Tie2-Cre mice were created, and their vascular and lymphatic endothelial cells expressing tsTAg could be cultured in vitro at 33°C (Yamaguchi et al., FEBS J., 2008). In this study, we established immortalized and cloned pancreatic epithelial cell lines from T26; Pdx1-Cre mice which expressed tsTAg in pancreatic epithelial cells in vivo by pancreas-specific Cre/loxP recombination. The cell lines were categorized into 1) ductal epithelial cell group which expressed CK19 and Sox9, and 2) acinar cell group which expressed Amylase2A of a digestive enzyme. In order to elucidate regulatory mechanisms of ductal cell differentiation and their plasticity, the immortalized ductal cell lines were cultured in collagen gel. A part of the cells formed spheroid or elongated and blanched architecture in the gel. Confocal or electron microscopic analysis indicated that their architectures had lumens with micro villi inside, and a part of them had tight junction at intercellular domain. It is noteworthy that the spheroid property changed into the elongated ductal (tubular) property by TGF-β stimulation in the 3D culture system, and the ductal architecture formation was suppressed by inhibitor of TGF-β signaling. 3D time-laps microscopic analysis demonstrated that a part of sphere-forming cells could change into duct-forming cells by TGF-β, which suggested existence of stem cells with susceptibility to TGF-β stimulation. The effect of TGF-β to change sphere-forming property into duct-forming property could be confirmed partially in some originally established murine pancreatic cancer cell lines. Taken together, these results suggested that TGF-β is an important factor for pancreatic duct and cancer differentiation and their architecture formation. Citation Format: Takashi Yamaguchi, Sanae Ikehara, Yuzuru Ikehara. TGF-β differentiates immortalized pancreatic epithelial cells to form duct architecture in 3D culture. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2032. doi:10.1158/1538-7445.AM2014-2032
Reflux Esophagitis and the Water Bed-Reply
Authors: Martin S. Kleinman
Journal: JAMA (1987)

<h3>In Reply.—</h3> It was not my intention to give the water bed industry heartburn; rather, I had planned to raise their heads a bit. My feeling that water bed usage is associated with reflux esophagitis was a clinical observation. Communications from patients and gastroenterologists that I have received since publication of the letter have further supported this belief. Our study was done in an effort to obtain some very preliminary data in evaluation of this possible association. We regret the error in the<i>P</i>value. The criterion of 2+ esophagitis was employed because, in my own experience of more than 5000 esophagogastroscopies, I have been impressed that the grading "2 + " can be clearly distinguished from normal. The criterion of 2 + esophagitis was selected before review of the data. Patients using water beds at the time of their gastroenterological evaluation were considered water bed users. Some of the patients on whom
A proteasome inhibitor confers cardioprotection
Authors: H Lüss
Journal: Cardiovascular Research (2002)

Objective: In several cell types, proteasome inhibitors like carbobenzoxyl-leucinyl-leucinyl-leucinal (MG132) induce the 72 kDa heat shock protein (Hsp72) and exert cell protective effects. However, data in cardiomyocytes are currently lacking. Methods and Results: We investigated the effects of MG132 in cultured neonatal rat cardiomyocytes. MG132 time- and concentration-dependently induced Hsp72 and Hsp32 at mRNA and protein levels. Although Hsp60 mRNA was induced, Hsp60 protein levels were not altered. MG132 activated p38 MAP kinase already after 0.5 h. Hsp mRNA induction started after 2 h of MG132 treatment. Subsequently, Hsp72 and Hsp32 protein levels were increased after 4 h. SB202190, an inhibitor of p38 MAP kinase, concentration-dependently attenuated MG132-induced Hsp72-and Hsp32-elevations (by 59% and 41%, respectively, at 1 μM SB202190). In contrast, herbimycin A, a known inductor of Hsp72 in cardiomyocytes, enhanced the MG132-induced Hsp72 and Hsp32 expression even further: additionally applied 2 μM herbimycin A induced Hsp72 and Hsp32 about 2-fold higher than 1 μM MG132 alone. MG132 (1 μM) decreased the hyperthermia- or hydrogen peroxide-induced release of lactate dehydrogenase by 45% and by 35%, respectively (P<0.05, n=5). MG132 (1 μM) prolonged the spontaneous beating time of cardiomyocytes at 46 °C from 5±2 min (control hyperthermia) to 28±5 min (P<0.05, n=4). Thus, inhibition of the proteasome function by MG132 protects cardiomyocytes against hyperthermic or oxidative injury. This protective effect and Hsp induction were abolished by 1 μM SB202190. Conclusion: Proteasome inhibition results in p38 MAP kinase-dependent induction of Hsp72 and Hsp32 and might be a novel cardioprotective modality.
Models of the Physician-Patient Relationship
Authors: Andrew D. Firlik
Journal: JAMA (1992)

<h3>To the Editor.</h3> —Because we are always interested in concise, carefully trimmed conceptualizations of complex phenomena, we read with interest "Four Models of the Physician-Patient Relationship" by Emanuel and Emanuel.<sup>1</sup>While the article does manage to clearly characterize four models of the physician-patient relationship and argue "descriptively and prescriptively" in favor of one "ideal" relationship—the deliberative model—we feel that the pigeonholing of idealized approaches to patient care confuses rather than simplifies the whole matter. It is not wise to adopt any single model "as the shared, paradigmatic reference" of the physician-patient relationship. What strikes us as the most important and the most delicate and elusive aspect of the physician-patient relationship is the physician's potential ability to assimilate into the treatment of disease the diverse and changing desires of patients, allowing for moods, phases, growth, and idiosyncracies. While we don't believe in the concept of an ideal physician, we think
FOCAL INFECTION IN THE TONSIL CAUSING A TUBERCULOUS OPHTHALMIA
Authors: CECIL M. JACK
Journal: JAMA (1922)

Some of our best results following the use of radium in the recurrent group have been in the infraclavicular region.In some of these cases, applications of a radium pack have resulted in a complete disappearance of the growth.One of the patients has now gone one and a half years with no further evidence of disease to be made out.The details of radium therapy and the methods employed have been fully described in a recent article,1 and will not be described here.
Adolescent Healthcare: A Practical Guide
Authors: Kathleen Flecker
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Choline PET or PET/CT and Biochemical Relapse of Prostate Cancer
Authors: Laura Evangelista, Fabio Zattoni, Andrea Guttilla, Giorgio Saladini, Filiberto Zattoni, Patrick M. Colletti, Domenico Rubello
Journal: Clinical Nuclear Medicine (2013)

The increase of prostate-specific antigen (PSA) after radical retropubic prostatectomy (RP) or external beam radiotherapy (EBRT) is the most sensitive tool for detecting prostate cancer (PCa) recurrence, although this measure cannot distinguish between local, regional, or distant recurrence. The aim of this meta-analysis was to evaluate the diagnostic performance of 18F-choline and 11C-choline PET or PET/CT in detection of locoregional or distant metastases in PCa.Medline, Web of Knowledge, and Google Scholar search was carried out in order to select English-language articles dealing with diagnostic performance of both 18F-choline and 11C-choline PET for the detection of PCa recurrence after RP or EBRT. Articles were included only if absolute numbers of true-positive, true-negative, false-positive, and false-negative test results were available or derivable from the text and regarded local, lymph node, and distant metastases. Reviews, clinical reports, and editorial articles were excluded. All complete studies were re-analyzed thus performing a quantitative analysis.From the years 2000 to 2012, we found 53 complete articles that critically evaluated the role of choline PET in restaging patients with PCa recurrence. The meta-analysis was carried out and dealt with 19 selected studies (12 studies for all sites of disease, 3 for lymph node metastases, and 4 for local recurrence), with a total of 1555 patients. The meta-analysis provided a pooled sensitivity of 85.6% (95% CI: 82.9%-88.1%) and pooled specificity of 92.6% (95% CI: 90.1%-94.6%) for all sites of disease (prostatic fossa, lymph nodes, and bone), a pooled sensitivity of 75.4% (95% CI: 66.9%-82.6%) and pooled specificity of 82% (95% CI: 68.6%-91.4%) for prostatic fossa recurrence, and a pooled sensitivity of 100% (95% CI: 90.5%-100%) and pooled specificity of 81.8% (95% CI: 48.2%-97.7%) for lymph node metastases. The heterogeneity ranged between 0.00% and 88.6%. The diagnostic odds ratios were 62.123 (95% CI: 24.783-155.72), 5.869 (95% CI: 1.818-18.946), and 138.57 (95% CI: 11.27-1703.8), respectively, for all sites of disease, local recurrence, and lymph node disease.Choline PET and PET/CT represent high sensitivity and specificity techniques for the detection of locoregional and distant metastases in PCa patients with recurrence of disease. Moreover, a high diagnostic odds ratio was found for the identification of lymph node disease in patients with biochemical recurrence of PCa.
Care of high risk pregnant women should be concentrated in fewer places
Authors: Zosia Kmietowicz
Journal: BMJ (2007)

Maternity services in England should be reorganised, with some run solely by midwives and fewer hospitals providing consultant led services for women at higher risk and with particular needs, says a report on maternity services. 

Sheila Shribman, national clinical director for children, young people, and maternity services, who launched two reports this week, emphasised that the care of pregnant women and ill children “isn't all about hospitals.” 

“You may see a hospital that has consultant obstetric care changing to one which has midwifery led …
24 MISSED OPPORTUNITIES FOR HBV SCREENING: RESULTS OF A LARGE SCREENING CAMPAIGN IN THE COMMUNITY, FRANCE 2011
Authors: J. Bottero, A. Boyd, M. Lemoine, J. Gozlan, A. Collignon, N. Boo, P. Dhotte, B. Varsat, G. Muller, O. Cha, J. Nau, P. Campa, O. Picard, B. Silbermann, M. Bary, P.-M. Girard, K. Lacombe
Journal: Journal of Hepatology (2012)
Phosphatidylinostol 3-Kinase Mediates Angiogenesis and Vascular Permeability Associated with Ovarian Carcinoma
Authors: Limin Hu, Judith Hofmann, Robert B. Jaffe
Journal: Clinical Cancer Research (2005)

Abstract Purpose: To assess the role of phosphatidylinositol-3 kinase (PI3K) inhibition in vascular permeability, angiogenesis, and vascular remodeling in tumor vessels and peritoneal lining in an athymic mouse model of i.p. human ovarian carcinoma. Experimental Design: Mice were inoculated i.p. with cells from the human ovarian cancer cell line, OVCAR-3. Fourteen days after inoculation, mice were treated with or without the PI3K inhibitor LY294002, 3 days weekly for 4 weeks. At the end of the experiment, some mice were anesthetized and injected via the tail vein with FITC-labeled lycopersicon lectin and perfused through the aorta before sacrifice. The peritoneal wall and tumor from all mice were removed and embedded in 10% agarose. Tumor sections were visualized by fluorescence microscopy. Results: Ascites in the LY294002-treated group (0.69 ± 0.27 mL) was reduced by 72.4% compared with the control group (2.5 ± 1.2 mL). Tumor burden in the LY294002-treated group (0.62 ± 0.32 g) was reduced by 47.3% compared with the control group (1.18 ± 0.41 g). LY294002 inhibited peritoneal and tumor vascularization resulting in numerous leaky, irregular, tortuous vessels in scant, straight, relatively impermeable vessels. Conclusions: The data indicate that LY294002 inhibits ascites formation in our mouse model of human ovarian cancer by inhibiting tumor and peritoneal neovascularization as well as vascular permeability. The data also show that LY294002 directly inhibits vascular endothelial growth factor (VEGF) protein expression and release from ovarian carcinoma and suggest that LY294002 blocks the VEGF signaling pathway involved in angiogenesis and vascular permeability.
Growing Use of Genomic Data Reveals Need to Improve Consent and Privacy Standards
Authors: Bridget M. Kuehn
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cell specificity in DNA binding and repair of chemical carcinogens.
Authors: J A Swenberg, D E Rickert, B L Baranyi, J I Goodman
Journal: Environmental Health Perspectives (1983)

Many animal models for organ specific neoplasia have been developed and used to study the pathogenesis of cancer. Morphologic studies have usually concentrated on the response of target cells, whereas biochemical investigations have usually employed whole organ homogenates. Since hepatocytes comprise nearly 90% of the liver's mass and 70-80% of its DNA, alterations in DNA replication, covalent binding and DNA repair of nonparenchymal cells are usually obscured when whole organ homogenates are used. By utilizing cell separation methods, we have been able to demonstrate differences between hepatocyte and nonparenchymal cell replication. DNA damage and repair following exposure to a variety of hepatocarcinogen. Differences in removal of simple O6-alkylguanine and DNA replication correlate with cell specific carcinogenesis of simply alkylating agents. For several other procarcinogens, including 2-acetylaminofluorene and dinitroluene, cell specificity appears to reside primarily in the differential metabolic competence of hepatocytes and nonparenchymal cells. This results in greater covalent binding of the carcinogen to hepatocyte DNA, although the DNA adducts are removed at a similar rate in both cell types.
European Union conference on poverty-related diseases research
Authors: Bruno Gryseels, Alimuddin Zumla, Marita Troye-Blomberg, Marie Paule Kieny, Gianluca Quaglio, Andreas Holtel, Hannu Laang, Manuel Romaris, Maria Teresa De Magistris, Ana Nieto Nuez, Ole F Olesen, Rachida Ghalouci, Anna Lönnroth
Journal: The Lancet Infectious Diseases (2009)
Management of blisters in minor burns.
Authors: A H Swain, B S Azadian, C J Wakeley, P G Shakespeare
Journal: BMJ (1987)

Les avis sont partages. L'etude de 202 cas montre que les bulles laissees intactes sont moins souvent infectees, et surtout moins souvent infectees par staphylocoques, que celles ponctionnees ou ouvertes
Medicine in Dachau
Authors: H. Rosencher
Journal: BMJ (1946)

Of 293,000 French people deported to Germany 42,000 came back, and 650% of these were found to be in bad health on their arrival in France.In this article, the mcdical aspects of life in a concentration carmp are described, the facts being taken from Dachau, where I spent 8 nonths.The subject is considered under four headings-hygiene, morbidity factors, medical organization, and the pathology of the internee, the part played by starvation and overcrowding being emphasized, wxith a finial note on the commonest sequelae of life in the camp as shown by a follow-up of 1,000 cases in the Department of the Seine.