Diagnostic Significance of Lymphocytes in Pleural Effusions
Authors: LUNG T. YAM
Journal: Annals of Internal Medicine (1967)

Diagnosis and Treatment1 May 1967Diagnostic Significance of Lymphocytes in Pleural EffusionsLUNG T. YAM, M.D.LUNG T. YAM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-972 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the pleural cavities of normal human subjects, there are small amounts of fluid that lubricate the linings. This fluid is minute in volume, difficult to obtain, and has not been studied extensively. When pleural effusions have accumulated and become clinically evident, they are easily available and are always of pathologic significance. Although cytologic examination of the effusions was recorded as early as in 1875 (1), reports dealing with the significance of cytologic patterns other than neoplastic cells are few and sporadic (2-8).In the course of a clinical, cytologic, and histologic study of a group of patients with pleural...References1. QUINCKE H: Ueber fetthaltige Transsudate. Hydrops chylosus und Hydrops adiposus. Deutsch. Arch. Klin. Med. 16: 121, 1875. Google Scholar2. WIDALRAVAUT FP: Applications cliniques de l'étude histologique des épanchements séro-fibrineux de la plèvre. C. R. Soc. Biol. (Paris) 52: 648, 651, 653, 1900. Google Scholar3. WIHMAN G: A contribution to the knowledge of the cellular content in exudates and transudates. Acta Med. Scand. 130 (suppl. 205): 1, 1948. MedlineGoogle Scholar4. LUSEREAGAN SAJW: A histocytological study of effusions. I. Effusions not associated with malignant tumors. Cancer 7: 1155, 1954. CrossrefMedlineGoogle Scholar5. GRUNZE H: Klinische Zytologie der Thoraxkrankheiten. Ferdinand Enke, Stuttgart, 1955. Google Scholar6. SPRIGGS AI: The Cytology of Effusions in the Pleural, Pericardial and Peritoneal Cavities. Grune & Stratton, Inc., New York, 1957. Google Scholar7. SPRIGGSBODDINGTON AIMM: Absence of mesothelial cells from tuberculous pleural effusions. Thorax 15: 169, 1960. CrossrefMedlineGoogle Scholar8. KOURILSKYKOURILSKYPIÈRONCOMBRISSONDECROIXJACQUILLATVASTEL RSRAGCC: Valeur diagnostique des investigations biologiques dans les épanchements séro-fibrineux de la plèvre. Vitesse de sedimentation, lactico-dehydrogenase, glucose, prothrombine, albumine, cytologie. Rev. Tuberc. (Paris) 27: 23, 1963. MedlineGoogle Scholar9. RIU CH: A study of staining methods of the Romanowsky series. J. Niigata Med. Ass. 70: 635, 1956. Google Scholar10. YAM LT: A rapid method to prepare smears of effusions and solid mass aspirates for cytologic diagnosis. Amer. J. Clin. Path. June 1967. CrossrefMedlineGoogle Scholar11. COPE C: New pleural biopsy needle. JAMA 167: 1107, 1958. CrossrefMedlineGoogle Scholar12. ABRAMS LD: A pleural biopsy punch. Lancet 1: 30, 1958. CrossrefMedlineGoogle Scholar13. BERTEPFOTENHAUER SJMA: Massive pleural effusion in sarcoidosis. Amer. Rev. Resp. Dis. 86: 261, 1962. MedlineGoogle Scholar14. EATONLITTLESILVER OMPFHM: Infectious mononucleosis with pleural effusion. Review of the literature. Arch. Intern. Med. (Chicago) 115: 87, 1965. CrossrefMedlineGoogle Scholar15. BERGERSECKLER HWSG: Pleural and pericardial effusions in rheumatoid disease. Ann. Intern. Med. 64: 1291, 1966. LinkGoogle Scholar16. WEISS W: Needle biopsy of the parietal pleura in tuberculosis. Amer. J. Med. Sci. 234: 431, 1957. CrossrefMedlineGoogle Scholar17. LEVINECUGELL HDW: Blunt-end needle biopsy of pleura and rib. Arch. Intern. Med. (Chicago) 109: 516, 1962. CrossrefMedlineGoogle Scholar18. MESTITZPURVESPOLLARD PMJAC: Pleural biopsy in the diagnosis of pleural effusions. Lancet 2: 1349, 1958. CrossrefMedlineGoogle Scholar19. SCHREKRABINOWITZ RY: Effects of phytohemagglutinin on rat and normal and leukemic human blood cells. Proc. Soc. Exp. Biol. Med. 113: 191, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LUNG T. YAM, M.D.Affiliations: Boston, MassachusettsFrom the Blood Research Laboratory, New England Medical Center Hospitals, and the Department of Medicine, Tufts University School of Medicine, Boston, Mass.This study was aided by grant CA 04168-09, the National Cancer Institute, National Institutes of Health, Bethesda, Md.Dr. Yam is a Research Fellow in Hematology, the Blood Research Laboratory, New England Medical Center Hospitals, Boston, Mass.Requests for reprints should be addressed to Lung T. Yam, M.D., Blood Research Laboratory, New England Medical Center Hospitals, Boston, Mass. 02111. 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