tbuckley/cabot-search huggingface dataset:
Metabolic clearance rate of radioiodinated human calcitonin in man
Authors: Raymond Ardaillou, Pierre Sizonenko, Alain Meyrier, Gabriel Vallée, Christian Beaugas
Journal: Journal of Clinical Investigation (1970)

The characteristics of the disappearance of radioiodinated synthetic human calcitonin from plasma have been studied in man. After single injection the disappearance curve was multiexponential. The number of exponentials of the theoretical curve fitting the best with the experimental data varied individually. Metabolic clearance rate was determined both from single injection and constant infusion studies, and fast initial distribution volume from the former. Metabolic clearance rate values in normal man calculated from constant infusion studies were 82.3 ±3.4 ml/min per m2. Values derived from single injection studies were similar, 77.0 ±4.7 ml/min per m2. These results were compared to those obtained in end stage, renal failure patients. Metabolic clearance rate was considerably lower and volume of fast initial distribution slightly larger in that group. This fact emphasizes the important role of kidneys in the utilization and/or the degradation of human calcitonin.
An optical study of human hair colour in normal and abnormal conditions.
Authors: G.H. FINDLAY
Journal: British Journal of Dermatology (1982)

Journal Article An optical study of human hair colour in normal and abnormal conditions. Get access G.H. FINDLAY G.H. FINDLAY Department of Dermatology, University of Pretoria, Pretoria, South Africa Prof G.H. Findlay, Faculty of Medicine, P.O. Box 667, 0001 Pretoria, South Africa. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 107, Issue 5, 1 November 1982, Pages 517–527, https://doi.org/10.1111/j.1365-2133.1982.tb00401.x Published: 01 November 1982 Article history Accepted: 22 January 1982 Published: 01 November 1982
P3-141: Assessments of the epidermal growth factor receptor mutations and amplification and their clinical implication in patients with lung adeno-carcinoma
Authors: Hee-Jung Sohn, Sang-We Kim, Jene Choi, Se Jin Jang, Dae Ho Lee, Cheolwon Suh, Dong Kwan Kim, Seung-Il Park, Woo Sung Kim, Jung-Shin Lee
Journal: Journal of Thoracic Oncology (2007)
Abstract 1200: BP1 regulates ERα activity in MCF-7 cells
Authors: Patricia E. Berg, Sanket Awate, Saurabh Kirolikar, Arnold Schwartz
Journal: Cancer Research (2011)

Abstract Introduction. BP1 is a member of the homeobox gene family of transcription factors. Our recent studies have shown that BP1 may play a role in breast cancer cell survival, aggressiveness and metastasis. BP1 protein (pBP1) is expressed in 80% of invasive ductal breast tumors, and is associated with estrogen receptor negativity – 100% of ERα negative (hereafter called ER-) tumors expressed BP1, while 73% of ER positive (ER+) tumors expressed BP1; this difference was statistically significant (p=0.03). Initially most tumors are hormone dependent and are sensitive to antiestrogens. Over time, many tumors progress to hormone-independence. One possible mechanism by which this might occur is reduction of ER protein. Here we present data indicating that high BP1 expression decreases ER protein levels in ER+ cells grown in the absence of serum. Since it is not currently understood what factors may cause ER+ cells to become more ER negative, it is important to determine the role of BP1 in reducing ER protein levels. Results. Our data suggest that MCF-7 ER+ cells engineered to overexpress BP1, when grown in the absence of serum, exhibit decreased ER protein compared with control cells containing an empty vector and grown under the same conditions. This is not a transcriptional effect since there was no change in ER mRNA levels in the presence of high levels of BP1. There was also a decrease in ER immunostaining in cells overexpressing BP1 grown without serum. Decreased ER protein levels correlated with decreased expression of pS2, a known downstream target of ER, demonstrating that there is less functional ER protein in cells overexpressing BP1 when grown in the absence of serum. We speculate that regulation of ER levels by BP1 is post-translational. Several pathways that control ER protein stability are being evaluated in cells grown with or without serum. Phosphorylation of Akt on Ser473, the site that is known to phosphorylate and stabilize ER protein, is being investigated to determine whether BP1 regulates phospho Akt levels. MAPK signaling can result in activation of ER in the absence of estrogen, but we did not see any evidence that BP1 is involved in the MAPK pathway. p300 is known to acetylate and stabilize ER protein; experiments are underway to determine whether BP1 directly regulates p300 expression since there are two potential BP1 binding sites in the p300 gene. Conclusions. We hypothesize that BP1 overexpression leads to reduced ER protein in ER positive cells. This could result in decreased sensitivity to antiestrogens in those cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1200. doi:10.1158/1538-7445.AM2011-1200
Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function
Authors: Lisa S. Westerberg, Carin Dahlberg, Marisa Baptista, Christopher J. Moran, Cynthia Detre, Marton Keszei, Michelle A. Eston, Frederick W. Alt, Cox Terhorst, Luigi D. Notarangelo, Scott B. Snapper
Journal: Blood (2012)
Efficacy and safety of medium- and high-dose diltiazem alone and in combination with digoxin for control of heart rate at rest and during exercise in patients with chronic atrial fibrillation.
Authors: A Roth, E Harrison, G Mitani, J Cohen, S H Rahimtoola, U Elkayam
Journal: Circulation (1986)

We evaluated the efficacy and the safety of medium-(240 mn/day) and high-dose (360 mg/day) diltiazem alone and in combination with digoxin when used for control of heart rate in 12 patients with chronic atrial fibrillation. Medium-dose diltiazem was comparable to therapeutic dose of digoxin at rest (88 +/- 19 vs 86 +/- 12 beats/min) but superior during peak exercise (154 +/- 23 vs 170 +/- 20 beats/min; p less than .05). High-dose diltiazem resulted in better control of heart rate than digoxin both at rest (79 +/- 17 beats/min; p less than .05) and exercise (136 +/- 25 beats/min; p less than .05) but was associated with side effects in 75% of the patients. Combined therapy of digoxin and diltiazem enhanced the effect of digoxin alone and resulted in significantly better control of heart rate at rest (67 +/- beats/min with medium-dose and 65 +/- beats/min with high-dose diltiazem) and during peak exercise (132 +/- 32 and 121 +/- 24 beats/min, respectively). However, the difference in heart rate between these two doses was not significant. Reduction of heart rate combined with concomitant effect on blood pressure resulted in a significant fall in pressure-rate product at rest from 10,077 +/- 1708 mm Hg/min on digoxin alone to 7877 +/- 1818 mm Hg/min after the addition of medium-dose diltiazem (p less than .05) and during exercise form 25,670 +/- 3606 to 18,439 +/- 4115 mm Hg/min (p less than .05). Continued therapy with digoxin combined with diltiazem 240 mg/day for 21 +/- 8 days in nine patients showed persistent effect on heart rate and blood pressure without any toxic manifestations or change in serum digoxin (1.5 +/- 0.4 vs 1.3 +/- 0.4 ng/ml) or plasma diltiazem concentrations (204 +/- 72 vs 232 +/- 129 ng/ml). In conclusion, medium-dose diltiazem when combined with digoxin is an effective and safe regimen for the treatment of patients with chronic atrial fibrillation and enhances digoxin-mediated control of heart rate both at rest and during exercise.
The Antilipidemic Effects of Ezetimibe in Patients With Diabetes
Authors: Jeffrey S. Stroup, Michael P. Kane, Robert S. Busch
Journal: Diabetes Care (2003)

The Adult Treatment Panel (ATP)-III guidelines list diabetes as a coronary heart disease (CHD) risk equivalent (1). Therefore, the LDL cholesterol goal of <100 mg/dl for patients with diabetes is equivalent to that of patients with known CHD (1,2). Hydroxymethylglutaryl-CoA reductase inhibitor (statin) therapy is recommended as first-line treatment in diabetic patients with elevated LDL cholesterol levels (2,3). Despite maximum statin doses, not all patients are able to reach this goal. In addition, some patients experience drug-induced side effects when statin doses are titrated upwards in an attempt to reach that goal. In such cases, lipid-lowering combination therapy may be warranted because doubling the statin dose has been shown to only …
Effect of dietary protein restriction on nutritional status in the Modification of Diet in Renal Disease Study
Authors: Joel D. Kopple, Andrew S. Levey, Tom Greene, W. Cameron Chumlea, Jennifer J. Gassman, Donna L. Hollinger, Bradley J. Maroni, Donna Merrill, Laura K. Scherch, Gerald Schulman, Shin-Ru Wang, Gail S. Zimmer, None Modification of Diet in Renal Disease Study Group
Journal: Kidney International (1997)
Putting knowledge to work
Authors: Derek Browne
Journal: Behavioral and Brain Sciences (1997)

Representational redescription (Karmiloff-Smith 1994a; 1994) translates implicit, procedural knowledge into explicit, declarative knowledge. Explicit knowledge is an enabling condition of cognitive flexibility. The articulation and inferential integration of knowledge are important in explaining flexibility. There is an interesting connection to the availability of knowledge for verbal report, but no clear explanatory work is done by the idea of knowledge that is available to consciousness.
A day in the field that changed my methodology
Authors: S. Goenka
Journal: BMJ (2002)

In India, more than 60% of the population use the services of private general practitioners. I had planned a study to assess GPs' knowledge of diabetes using a quantitative questionnaire based on semi-structured interviews. To pilot my questionnaire I went into a densely populated area of north Delhi and noticed how patients could choose a doctor from many on the same street.

I stepped into a private GP's clinic, introduced myself, and explained the purpose of my visit. This clinic was small. It had a desk, an old cabinet, a partition behind which the GP examined the patients, a washbasin, and some chairs and benches for patients to sit on. The paint was peeling off the walls. It was the peak of summer with temperatures reaching 44°C, but the fans were not working …
A comparative study of the promotion of tissue plasminogen activator and pro-urokinase-induced plasminogen activation by fragments D and E-2 of fibrin.
Authors: J N Liu, V Gurewich
Journal: Journal of Clinical Investigation (1991)

Plasmin generation by equimolar concentrations of tissue plasminogen activator (t-PA), pro-urokinase (pro-UK), and urokinase (UK), and a twofold higher concentration of a plasmin-resistant mutant rpro-UK (Ala-158-pro-UK) was measured on a microtiter plate reader. The promoting effects on this reaction of equimolar concentrations of fibrinogen, soluble fibrin (Desafib), CNBr fragment FCB-2 (an analogue of fragment D), or purified fragment E-2 were compared. Plasmin generation by t-PA was moderately promoted by fibrinogen, substantially promoted by Desafib and FCB-2, but not at all promoted by fragment E-2. By contrast, plasmin generation by pro-UK or by Ala-158-pro-UK was not promoted either by fibrinogen, Desafib, or FCB-2, but was significantly promoted by fragment E-2. Plasmin generation by UK was not significantly promoted by any of the fibrin(ogen) preparations. Treatment of fragment E-2 by carboxypeptidase-B (CPB), eliminated its promotion of pro-UK and Ala-158-pro-UK-induced plasmin generation. Pretreatment of FCB-2 with plasmin slightly potentiated its promotion of t-PA activity. This effect of plasmin pretreatment of FCB-2 was reversed by CPB treatment. Plasmin pretreatment of FCB-2 did not induce any promotion of activity in pro-UK or Ala-158-pro-UK. The findings show that the intrinsic activity of pro-UK and the activity of t-PA are promoted by different regions of the fibrin(ogen) molecule. The latter is stimulated primarily by a determinant in the fragment D region, which is available in intact fibrin. By contrast, plasminogen activation by the intrinsic activity of pro-UK was stimulated exclusively by fragment E-2, which is unavailable in intact fibrin. The findings are believed relevant to fibrinolysis and support the concept that t-PA and pro-UK are complementary, sequential, and synergistic in their actions.
Time to Get Serious About Pay for Performance
Authors: Ashish K. Jha
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
POST-FEBRILE INSANITY AND ITS TREATMENT.
Authors: FRANK PARSONS NORBURY
Journal: JAMA (1900)

All disorders that affect general nutrition of the body may affect the mind. The brain, the organ of the mind, is sensitive to nutritional changes, and when these are profound they may permanently affect the mind's nature. The imperceptible fluctuations of brain nutrition have concomitant fluctuations of mental action, and these physical processes, if carefully studied, reveal to us that there is physical basis to mind. The physiology of mind need not be discussed here nor need we wander into the psychologic labyrinths to study the relationship of body to mind. It is only necessary to state, whatever is the organic process of mental action, its basis is, like that of other elements, in the cell. The brain-cell has its organization and its nutrition; perversion of either causes disturbance of function. This disturbance when changing the routine and characteristics of an individual mental life, we sometimes call insanity. But do
THE STATE OF THE BLOOD VESSELS OF THE FACE IN ROSACEA—I
Authors: PETER BORRIE
Journal: British Journal of Dermatology (1955)

Journal Article THE STATE OF THE BLOOD VESSELS OF THE FACE IN ROSACEA—I Get access PETER BORRIE, M.A., M.D., M.R.C.P. PETER BORRIE, M.A., M.D., M.R.C.P. Dermatologist, Moorfields, Westminster and Central Eye Hospitals, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 67, Issue 1, 1 January 1955, Pages 5–8, https://doi.org/10.1111/j.1365-2133.1955.tb12649.x Published: 01 January 1955
Catecholamines in the Localization of Pheochromocytoma
Authors: J. RICHARD CROUT, ALBERT SJOERDSMA
Journal: Circulation (1960)

Data on urinary catecholamines in a collected series of 75 cases of pheochromocytoma, including 18 of our own cases, indicate that the differential assay of urinary norepinephrine and epinephrine may be of value in predicting the location of the tumor preoperatively. If there is a significant elevation of urinary epinephrine (42 per cent of all cases), the tumor may be expected to lie in or adjacent to one of the adrenal glands in about 95 per cent of cases. Other tumors of this type have been found only in the organs of Zuckerkandl. If the urine contains norepinephrine alone (58 per cent of all cases), the tumor will be found in one of the adrenal areas in about two thirds of the cases and in an extra-adrenal location in the remainder. In a few patients (6 per cent) of this type, the tumor may be extra-abdominal. In some unusual cases more precise information on the location of the tumor must be obtained preoperatively. The demonstration of a marked step-up in plasma catecholamine concentration at the level of the tumor, the sampling being done by venous catheterization, is a useful and safe means of localizing the tumor. Five cases are presented illustrating the use of this procedure.
Heat-Labile Enzymes in Skin Fibroblasts from Subjects with Progeria
Authors: Samuel Goldstein, Elena Moerman
Journal: New England Journal of Medicine (1975)

To characterize further the genetic basis of progeria, thermolability studies were performed on three genetically distinct enzymes in crude extracts of cultured skin fibroblasts derived from two subjects with that syndrome. At early passage the progeric fibroblasts, as compared to controls, contained a significantly higher percentage of heat-labile glucose-6-phosphate dehydrogenase (12.83 plus or minus 1.72 vs 1.11 plus or minus 0.44 [mean plus or minus S.E.M.], p smaller than 0.001), 6-phosphogluconate dehydrogenase (9.71 plus or minus 0.68 vs. 0.67 plus or minus 0.22, p smaller than 0.001), and hypoxanthine-guanine phosphoribosyltransferase (31.41 plus or minus 1.89 vs 7.67 plus or minus 1.71, p smaller than 0.001), and the differences were maintained throughout the in vitro life-span. These data, in conjunction with previous reports of defective HL-A antigens, indicate a widespread defect in genetic expression. The most likely cause appears to be an aberration in protein synthesis or degradation, or both, although multiple somatic mutations cannot be ruled out. Increased thermolability of enzymes in cultured cells may provide a screening test for persons predisposed to progeria and other disorders of premature aging.
ASCO: Patients With Advanced Cancer Need Advice on End-of-Life Care Options
Authors: Bridget M. Kuehn
Journal: JAMA (2011)

greater than 1 million; no metastasis or recurrence occurred in patients with tumors that had less than 250 000 copies. In mice models, the researchers demonstrated that treatment to minimize CPENlevelswithCPEN–specificantisenseRNAstoppedtumorspreadorthe formation of new tumors. Although the resultsarepromising,Lohcautionedthat currently there are no means to deliver the antisense RNA to tumor cells. In commenting on the research findings,SonaliSmith,MD,anassociateprofessorofmedicineattheUniversityofChicago Medical Center, said the study was welldoneandsuggeststhatCPENlevel has the potential to be an important biomarker in predicting metastasis. However, Smith did offer a couple caveats. “In the study, they state that this protein induces metastasis, but I do not thinktheyshowthat; theyshowthisbiomarker is correlated with the risk of metastasis,” Smith said. “One other issue is that theyaremeasuringtheseproteinlevelsinthetumoritself,butifyoureallywant a biomarker that is user-friendly, you wouldlikeabloodtest.”Smithaddedthat the study’s findings need confirmation. Loh said larger studies intended to validate the findings are under way. Meanwhile, for Hewitt, these results offer optimism about improvements in stratifying patients’ risk for recurrence and metastasis. “The biomarker has now been used in 2 very different and unrelated cancers, pericellular carcinoma as well as pheochromocytoma and paraganglioma,” Hewitt said. “There may be something that separates this biomarker from many of the other biomarkers that were previously identified, which are usually in a single tumor.”
US courts in conflict over late term abortion
Authors: F. Charatan
Journal: BMJ (1999)

A federal court last month upheld the constitutionality of laws in Illinois and Wisconsin that ban late term abortion.

The sharply divided 5-4 opinion of the US Seventh Circuit Court of Appeals conflicted with the decision taken in September by the Eighth Circuit Court of Appeals declaring similar bans in Nebraska, Arkansas, and Iowa to be unconstitutional.

The laws in Wisconsin and Illinois allow the prosecution of doctors who …
Letter by Barrios et al Regarding Article, “Impact of Proteinuria and Glomerular Filtration Rate on Risk of Thromboembolism in Atrial Fibrillation: The Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study”
Authors: Vivencio Barrios, Carlos Escobar, Rocio Echarri
Journal: Circulation (2009)

Fibrillation (ATRIA) Study"We read the article by Go et al 1 about the impact of proteinuria and glomerular filtration rate on the risk of thromboembolism in patients with atrial fibrillation.Interestingly, the authors found that after adjustment for known risk factors for stroke and other confounders, proteinuria increased the risk of thromboembolism by 54%, and there was a graded increased risk of stroke associated with a progressively lower level of estimated glomerular filtration rate compared with a rate Ն60 mL/min per 1.73 m 2 : relative risk of 1.16, for estimated glomerular filtration rate of 45 to 59 mL/min per 1.73 m 2 and relative risk of 1.39 for estimated glomerular filtration rate Ͻ45 mL/min per 1.73 m 2 (Pϭ0.0082 for trend).In patients receiving long-term dialysis, atrial fibrillation appears to be a common complication, and some studies suggest that the arrhythmia further increases the risk of ischemic stroke. 2,3However, current atrial fibrillation guidelines do not include chronic kidney disease and proteinuria as potential risk factors for thromboembolic events. 4his omission could directly translate into an underuse of anticoagulation in daily clinical practice and, as a result, an increase in cardiovascular morbidity and mortality.For instance, in a hypertensive population with chronic ischemic heart disease attended by a cardiologist, in which the presence of atrial fibrillation is more frequent with renal dysfunction (26% in patients with an estimated glomerular filtration Ͻ60 mL/min per 1.73 m 2 versus 12% in those with Ն60 mL/min per 1.73 m 2 ), only 22% of patients with chronic renal disease were taking anticoagulants. 5ll these data highlight, first, that the current scores performed to assess the risk of thromboembolism in patients with atrial fibrillation are likely incomplete.There are other risk factors not currently considered, such as coronary artery disease or chronic kidney disease, that may be taken into account, and this could be one of the reasons that cardioembolic events are still frequent.If these and other risk factors are not included, physicians may underestimate the thromboembolic risk and subsequently underuse antithrombotic therapy. 4Second, although some physicians do not prescribe anticoagulants in patients with renal disease because of the potential risk of bleeding complications, particularly in those receiving long-term dialysis, the current evidence plainly supports the use of anticoagulation therapy in these patients.In conclusion, because chronic kidney disease increases the risk of thromboembolism in patients with atrial fibrillation, more efforts are warranted to extend the use of antithrombotic therapy in this population.The first step could include this condition in the risk scores.
GRIN2A mutations cause epilepsy-aphasia spectrum disorders
Authors: Gemma L Carvill, Brigid M Regan, Simone C Yendle, Brian J O'Roak, Natalia Lozovaya, Nadine Bruneau, Nail Burnashev, Adiba Khan, Joseph Cook, Eileen Geraghty, Lynette G Sadleir, Samantha J Turner, Meng-Han Tsai, Richard Webster, Robert Ouvrier, John A Damiano, Samuel F Berkovic, Jay Shendure, Michael S Hildebrand, Pierre Szepetowski, Ingrid E Scheffer, Heather C Mefford
Journal: Nature Genetics (2013)