tbuckley/cabot-search huggingface dataset:
Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinib
Authors: John C. Byrd, Richard R. Furman, Steven E. Coutre, Jan A. Burger, Kristie A. Blum, Morton Coleman, William G. Wierda, Jeffrey A. Jones, Weiqiang Zhao, Nyla A. Heerema, Amy J. Johnson, Yun Shaw, Elizabeth Bilotti, Cathy Zhou, Danelle F. James, Susan O'Brien
Journal: Blood (2015)
Haemorrhagic cystitis due to gentian violet.
Authors: C Walsh, A Walsh
Journal: BMJ (1986)

up.Three other subjects suffered nausea for about one hour after taking cyclosporin A.After 12 weeks' treatment cyclosporin A was withdrawn, and in all 10 patients the psoriasis relapsed, the time taken for relapse ranging from three days to two months.All side effects disappeared on withdrawal of the drug.1
Endocarditis Caused by a New Species of Pasteurella
Authors: DIETER W. GUMP
Journal: Annals of Internal Medicine (1972)

A case of Pasteurella endocarditis caused by an organism closely resembling P. multocida, but with characteristics sufficiently different from this organism to constitute a new and distinctive species, is presented. The biochemical and growth characteristics of this organism, referred to as Pasteurella new species, are compared with P. multocida. One of the striking differences between P. new species and P. multocida was the generation of gas during the fermentation of several different sugars by the new species. Another marked difference was the flocculent growth pattern produced by P. new species in liquid media, in contrast to the uniform turbidity produced by P. multocida in such media. The potentially serious nature of Pasteurella infections contracted from dogs and cats is again demonstrated by this case, as well as the necessity of early and vigorous local treatment of dog and cat bites, including the use of penicillin G for infections resulting from such bites.
Have Quality Improvement Efforts Decreased Mortality Rates Following Cardiac Surgery?
Authors: Edwin D. Huff
Journal: JAMA (1997)

<h3>To the Editor.</h3> —In reporting no apparent difference between declining coronary artery bypass graft (CABG) surgery mortality rate trends in Massachusetts and in New York and northern New England, Dr Ghali and colleagues<sup>1</sup>have identified something that could be characterized as embarrassing or, at least, surprising. What makes their conclusions difficult to interpret is the absence of information about what did or did not systematically happen during the periods studied. It is apparent from the titles and content of the article by Ghali et al,<sup>1</sup>the accompanying Editorial by Dr Jencks,<sup>2</sup>and an earlier Editorial by Berwick<sup>3</sup>that these authors have assumed that concerted quality improvement efforts took place during the periods surveilled. That the distinctive improvement efforts of any locale constituted any sort of systematic or stable and sustained intervention for any interim period studied is not apparent after reading the source articles.<sup>4,5</sup>How
The influence of the pituitary on arterial intimal proliferation in the rat.
Authors: M L Tiell, M B Stemerman, T H Spaet
Journal: Circulation Research (1978)

The formation of arteriosclerotic fibromusculoelastic intimal thickening following arterial de-endothelialization is well documented. Recent findings, both in vitro and in vivo, suggest that platelets are a major participant in the pathogenesis of this lesion by releasing a mitogen to medial smooth muscle cells (SMC). This mitogen results in SMC migration to and proliferation within the intima. A similar mitogen has been described as originating in brain and pituitary tissue. We now report that, in hypophysectomized rats with normal platelet counts, intimal hyperplasia is markedly delayed; pair-fed intact controls normally develop lesions. It therefore appears that the pituitary gland plays a significant role in the experimental arteriosclerotic response.
A re-examination of the whiplash associated disorders (WAD) as a systemic illness
Authors: R Ferrari
Journal: Annals of the Rheumatic Diseases (2005)

<b>Objective:</b> To describe the systemic nature of the illness reported after motor vehicle collisions using data from a large, population based cohort of individuals making an injury insurance claim. <b>Methods:</b> All subjects who submitted a claim or were treated for whiplash injury following a motor vehicle collision in Saskatchewan, Canada during an 18 month period were examined. Demographics of claimants, collision related data, pre-collision health data, symptom prevalence, and scores on the short form 36 item general health survey (SF-36) were obtained on average within one month post-collision. <b>Results:</b> Of 9006 potentially eligible claimants, 7462 (83%) met criteria for whiplash injury and provided information regarding demographics and injury related symptoms; 45% of these consented to complete the SF-36 at baseline. For most subjects, neck pain was only one of many diffuse and intense symptoms, including, often, low back pain. The range of symptoms, including fatigue, dizziness, paraesthesiae, headache, spinal pain, nausea, and jaw pain, could be interpreted as a systemic disorder. SF-36 scores showed low physical and mental functioning one month post-collision. <b>Conclusions:</b> What is commonly referred to as whiplash associated disorders (WAD) is best appreciated as a syndrome extending well beyond what can be labelled as a neck injury. More research is needed for a better understanding of the underlying mechanisms involved so that treatment can be directed at the broad spectrum of the illness rather than focusing on finding a focal neck injury.
Health Survey of Workers in Garment Industry as Part of Preventive-Medicine Program
Authors: Joseph H. Kaplan, Nathaniel N. Bennett, Grace Foley
Journal: New England Journal of Medicine (1951)

AMONG supposedly healthy workers in the garment industry, many serious but noncritical conditions were brought to light in a health survey sponsored by the Health and Welfare Fund of the International Ladies' Garment Workers' Union, A. F. of L., in an intermediate city,1 in western Massachusetts, beginning on December 20, 1947.A total of 855 out of 1050 employees, or 81.4 per cent, were examined on a voluntary basis under ordinary working conditions. The remaining 18.6 per cent refused the examination for various reasons, as indicated later in this paper. Of the total 855 employees examined, 684, or 80 per . . .
Is Colonoscopy Indicated for Small Adenomas Found by Screening Flexible Sigmoidoscopy?
Authors: Michael B. Wallace
Journal: Annals of Internal Medicine (1998)

Background: There is controversy over whether patients who have a small tubular adenoma on screening flexible sigmoidoscopy should undergo colonoscopic examination of the proximal colon. Objective: To prospectively determine the prevalence of advanced polyps in the proximal colon among patients who have small adenomas on screening sigmoidoscopy. Design: Prospective cohort study. Setting: A health maintenance organization and a Veterans Affairs medical center. Patients: Asymptomatic patients older than 50 years of age who had no risk factors for colon cancer and underwent sigmoidoscopy. Intervention: At the time of sigmoidoscopy, all polyps were biopsied and characterized. All patients with distal adenomas were offered colonoscopy. Measurements: The size and histology of polyps identified by sigmoidoscopy and colonoscopy were noted. Polyps were considered advanced if they were larger than 10 mm or were tubulovillous, villous, or malignant. The prevalence of advanced proximal polyps was determined, and patients were stratified by the size and number of distal polyps found by sigmoidoscopy. Results: Among 4490 patients who underwent sigmoidoscopy, a neoplastic lesion was detected in 401 (8.9%) and colonoscopy was done in 301 (75%). Of 90 patients with a single tubular adenoma 1 to 5 mm in diameter in the distal colon, 0% (95% CI, 0.0% to 4.0%) had an advanced proximal polyp compared with 5.4% (CI, 2.4% to 10.4%) of those who had multiple distal polyps 1 to 5 mm or 6 to 10 mm in diameter and 7.9% (CI, 2.6% to 17.6%) of those who had advanced distal polyps (P = 0.013 for trend). The low-risk group with a single tubular adenoma 1 to 5 mm in diameter represented 44% of all patients with distal adenomas or cancers found at flexible sigmoidoscopy. Conclusions: Among patients undergoing screening sigmoidoscopy, those with single tubular adenomas of 5 mm or less had a low prevalence of advanced proximal polyps. These patients may not benefit from colonoscopy.
Common Drugs Can Harm Elderly Patients
Authors: Rebecca Voelker
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medicolegal Applications of Blood Grouping
Authors: Fred H. Allen, A. Richardson Jones, Louis K. Diamond
Journal: New England Journal of Medicine (1954)

ONE of the branches of medical science that has undergone rapid expansion in the last decade is that of immunohematology, or the study of the blood groups and blood-group antibodies. In this new specialty, the accumulation of detailed knowledge of genetic composition on the basis of the blood groups present in red cells has led to unusually practical clinical and medicolegal concepts.Through the careful use of specific antiserums various blood groups and types are now susceptible of precise determination, and it has been well established that the ordinary laws of heredity operate in regulating the presence or absence of . . .
Enhancement by Secretin of the Apparently Maximal Hepatic Transport of Bilirubin in the Rat
Authors: Giovanni L. Ricci, Roger Michiels, Johan Fevery, Jan De Groote
Journal: Hepatology (1984)

The effect of secretin (0.4 C.U. per hr per 100 gm body weight) on bile flow and the apparent maximal hepatic transport of bilirubin (Tm) was investigated in the rat. When secretin was administered during an already established bilirubin-Tm condition, it increased bile flow and bilirubin-Tm by 15 to 20% over a 30- to 50-min period. Enhancement of bilirubin output correlated with augmented flow and was sustained by an increased rate of excretion of monoglucuronides. When secretin was given for 90 min before bilirubin loading, it enhanced biliary bilirubin concentration and output, largely as diglucuronides. Bilirubin-Tm correlated positively with glururonyltransferase activity in liver homogemates. In the isolated perfused rat liver, injection of secretin in the portal cannula failed to produce choleresis. Bilirubin uridine diphosphate-glucuronyltransferase activity was lower than in intact rats and higher after treatment than in controls. The effect of secretin had an early effect on hepatocytic bile flow and a later effect on conjugation. Maximal hepatic bilirubin output was modulated both by flow and conjugation rate; the two mechanism may act independently.
Genital-Tract Cancers in Adolescents and Young Adults
Authors: George Linden, Brian E. Henderson
Journal: New England Journal of Medicine (1972)

In a review of the California Tumor Registry from 1950-1969, which records 1/3 of all cancer cases in California, there was an increase in the number of cancers of the vagina, corpus uteri, prostate, testis, and bladder (male) for the 10-19 year old age group. There was no increase in cancers of the vulva, ovary, cervix, breast, stomach, colon, rectum, and bladder (female). However, for the 20-24 year old age group, cancer of the vulva and testis increased from 1962-1969. The increases are compatible with other observations which indicate a possible association between stilbesterol and other cervical sites besides the vagina. There is a need for cancer surveillance to determine disease patterns and stimulate examination of existing data.
Hematologic Profile and Lymphocyte Subpopulations in Hemoglobin SC disease: Comparison With Hemoglobin SS and Black Controls
Authors: Wing-Yen Wong, Darleen R. Powars, Eva A. Operskalski, James W. Mosley, Joseph Hassett, Yi Zhou
Journal: American Journal of Hematology (1996)

Compared with subjects with homozygous SS disease (Hb SS), persons with hemoglobin SC (Hb SC) are known to have a more gradual loss of splenic function, a lower incidence of bacterial infections, and fewer end-organ failures. We studied hematological indices and lymphocyte subpopulations of 27 Hb SC subjects and compared them with 173 Hb SS patients and 131 black controls. Hb SC patients had higher hemoglobin levels than Hb SS subjects, lower total leukocyte, granulocyte, monocyte, and lymphocyte counts. Platelets decresed with age but not significantly, instead of incressing as among Hb SS patients. Mononuclerar cells were generally similar to controls with the exception of CD8+HLA-DR+ counts resembling Hb SS, Hematologic changes in Hb SC are limited to moderate granulocytosis in children and aduts, mild monocytosis in aduts, and increased activation of just one lymphocyte subset among those measured.
The Familial Hyperchylomicronemia Syndrome
Authors: Silvia Santamarina-Fojo
Journal: JAMA (1991)

<h3>SELECTED CASE</h3> A 5-YEAR-OLD black boy was referred for evaluation of hypertriglyceridemia and recurrent episodes of abdominal pain. The proband, a 3.9-kg full-term infant with an uncomplicated gestation and vaginal delivery, was noted to have markedly lipemic plasma at 1 week of age. For the first 6 months of life, the infant suffered from severe abdominal bloating associated with emesis, which appeared to be temporally related to feeding. The frequency of these episodes decreased after the diet was changed to a medium-chain triglyceride—enriched formula. However, as the patient grew older, he continued to experience repeated episodes of severe abdominal pain associated with nausea and vomiting, and he was hospitalized twice with documented pancreatitis at the ages of 4 and 5 years. Fasting plasma triglyceride levels during the hospitalizations were 23.7 and 33.9 mmol/L, respectively. Family history was negative for the presence of hyperlipidemia, xanthomas, and pancreatitis. The parents' fasting triglyceride
Clinical course of dilated cardiomyopathy in asymptomatic patients long-term treated with beta-blocking agents: the heart muscle disease registry of Trieste
Authors: Andrea Di Lenarda, Gastone Sabbadini, Gerardina Lardierl, Mauro Driussi, Elisa Carniel, Laura Vitali Serdoz, Stefano Pangher, Gianfranco Sinagra
Journal: Journal of the American College of Cardiology (2002)
Prostaglandin E2 suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells
Authors: Zbigniew Zasłona, Katsuhide Okunishi, Emilie Bourdonnay, Racquel Domingo-Gonzalez, Bethany B Moore, Nicholas W Lukacs, David M Aronoff, Marc Peters-Golden
Journal: Journal of Allergy and Clinical Immunology (2013)
Intravascular Coagulation, Ascitic Fluid Infusion, and Endotoxin
Authors: DONATO FUMAROLA
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 December 1979Intravascular Coagulation, Ascitic Fluid Infusion, and EndotoxinDONATO FUMAROLA, M.D.DONATO FUMAROLA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-6-929_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We agree with the statement of Viallet and Villeneuve (1) about a close connection between intravascular coagulation and ascitic fluid infusion. We would like to indicate a possible pathogenetic mechanism for these disorders. Recent investigations have demonstrated that ascitic fluid can contain variable amounts of endotoxin, detected by the Limulus assay (GOLDBERGPK, KOZINNPJ, GROSSBERGSJ, WAPNICKS, LUPOVICIM. Increased endotoxemia following the LeVeen peritoneovenous shunt. 78th Annual Meeting of the American Society for Microbiology, Las Vegas, 14-19 May 1978. Abstract ct B 56). Because ascitic fluid exhibits procoagulant properties (PHILLIPSLL, RODGERSJB. Procoagulant...References1. VIALLETVILLENEUVE AJ. Intravascular coagulation and ascitic-fluid infusion. Ann Intern Med. 1979;91:318-9. Letter. LinkGoogle Scholar2. SEMERAROFUMAROLAMERTENSVERMYLEN NDFJ. Evidence that endotoxins enhance the Factor X activator activity of washed hyman platelets. Br J Haematol. 1978;38:243-9. CrossrefMedlineGoogle Scholar3. PUIGANTÓNGONZÁLEZVÁZQUEZ JFJJ. Peritoneovenous shunt and bacterial endotoxin. Mayo Clin Proc. 1979;54:133. Letter. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DONATO FUMAROLA, M.D.Affiliations: Department of Medical Microbiology Bari University School of Medicine 70124 Bari, Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHyperfibrinolysis but not hypercoagulability after a new ascites-apheresis procedure in liver cirrhosis patients with refractory ascitesAscites apheresis, concentration and reinfusion for the treatment of massive or refractory ascites in cirrhosisVascular problems in paroxysmal nocturnal haemoglobinuriaAscites, the LeVeen Shunt, and EndotoxinIVO BUHAC, M.D. 1 December 1979Volume 91, Issue 6Page: 929-929KeywordsEndotoxemiaEndotoxinsMicrobiologyPathogens ePublished: 1 December 2008 Issue Published: 1 December 1979 PDF downloadLoading ...
Disrupted Effective Connectivity of Cortical Systems Supporting Attention and Interoception in Melancholia
Authors: Matthew P. Hyett, Michael J. Breakspear, Karl J. Friston, Christine C. Guo, Gordon B. Parker
Journal: JAMA Psychiatry (2015)

Patients with melancholia report a distinct and intrusive dysphoric state during internally generated thought. Melancholia has long been considered to have a strong biological component, but evidence for its specific neurobiological origins is limited. The distinct neurocognitive, psychomotor, and mood disturbances observed in melancholia do, however, suggest aberrant coordination of frontal-subcortical circuitry, which may best be captured through analysis of complex brain networks.To investigate the effective connectivity between spontaneous (resting-state) brain networks in melancholia, focusing on networks underlying attention and interoception.We performed a cross-sectional, observational, resting-state functional magnetic resonance imaging study of 16 participants with melancholia, 16 with nonmelancholic depression, and 16 individuals serving as controls at a hospital-based research institute between August 30, 2010, and June 27, 2012. We identified 5 canonical resting-state networks (default mode, executive control, left and right frontoparietal attention, and bilateral anterior insula) and inferred spontaneous interactions among these networks using dynamic causal modeling.Graph theoretic measures of brain connectivity, namely, in-degree and out-degree of each network and edge connectivity, between regions composed our principal between-group contrasts.Melancholia was characterized by a pervasive disconnection involving anterior insula and attentional networks compared with participants in the control (Mann-Whitney, 189.00; z = 2.38; P = .02) and nonmelancholic depressive (Mann-Whitney, 203.00; z = 2.93; P = .004) groups. Decreased effective connectivity between the right frontoparietal and insula networks was present in participants with melancholic depression compared with those with nonmelancholic depression (χ2 = 8.13; P = .004). Reduced effective connectivity between the insula and executive networks was found in individuals with melancholia compared with healthy controls (χ2 = 8.96; P = .003).We observed reduced effective connectivity in resting-state functional magnetic resonance imaging between key networks involved in attention and interoception in melancholia. We propose that these abnormalities underlie the impoverished variety and affective quality of internally generated thought in this disorder.
Diagnosing Ovarian Cancer
Authors: Tracy Hampton
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long-term Mortality After Primary Prevention for Cardiovascular Disease
Authors: Thomas B. Newman
Journal: JAMA (1992)

In Reply.  —In regard to Drs Bassler and Bassler, our study was a multifactorial prevention trial involving, in addition to hypolipidemic medications, other intervention measures. Consequently, the results can only be applied to all these measures combined, including treatment of hypertension, so that it is irrelevant to talk about the real hazard of cholesterol reduction alone. Accordingly, application of our mortality data to 60 million Americans targeted for cholesterol lowering is totally misleading. Subgroup analyses performed so far have not supported the idea that hypolipidemic treatment alone could have caused the difference in total mortality.  In reply to Dr Holme, since the risk factor levels were similar in the two groups in 1985, we cannot see any special reason why they were much different after that. The death certificates were hardly biased in the intervention group because in virtually all cases without unequivocal lifetime hospital diagnosis, the cause of death