tbuckley/cabot-search huggingface dataset:
Flocculation and Loss of Potency of Human NPH Insulin
Authors: Edward A Benson, James W Benson, Paul N Fredlund, Robert S Mecklenburg, Robert Metz
Journal: Diabetes Care (1988)

In late 1986, several vials of Humulin N (NPH human insulin, recombinant DNA origin) came to our attention because of a clumped, white coating on the inside of the vials. To determine the frequency of this phenomenon, we surveyed 100 consecutive patients who used Humulin N. Ten patients had encountered 21 vials of flocculated insulin in the previous 12 mo, reflecting an incidence of 1 per 72 vials. Insulin drawn from affected vials was markedly reduced in potency: 20.9 ± 3.4 U/ml vs. the labeled potency of 100 U/ml. Several patients reporting flocculated insulin, including one hospitalized with ketoacidosis, experienced unusual and unexplained elevation in blood glucose concentration for several days before flocculation was observed. Patients who use NPH human insulin should be aware of this phenomenon and carefully inspect their vials for evidence of insulin precipitation before each injection.
Clinical Evaluation of Nuclear Dacryocystography
Authors: TAPAN K. CHAUDHURI
Journal: Clinical Nuclear Medicine (1976)

Using 99mTc-sodium pertechnetate, the radionuclide dacryocystogram (DCG) was employed to help detect obstruction in the lacrimal drainage apparatus. A total of 100 nuclear DCG's were performed in 50 patients who were being studied because of epiphora (tearing). The nuclear DCG was compared to the conventional roentgenographic DCG or an irrigation study in each of these patients. The findings in this report indicate that nuclear DCG is a reliable and dependable method to diagnose and visualize obstruction in the lacrimal drainage apparatus.
In Vivo Suppression of MicroRNA-24 Prevents the Transition Toward Decompensated Hypertrophy in Aortic-Constricted Mice
Authors: Rong-Chang Li, Jin Tao, Yun-Bo Guo, Hao-Di Wu, Rui-Feng Liu, Yan Bai, Zhi-Zhen Lv, Guan-Zheng Luo, Lin-Lin Li, Meng Wang, Hua-Qian Yang, Wei Gao, Qi-De Han, You-Yi Zhang, Xiu-Jie Wang, Ming Xu, Shi-Qiang Wang
Journal: Circulation Research (2013)

Rationale: During the transition from compensated hypertrophy to heart failure, the signaling between L-type Ca 2+ channels in the cell membrane/T-tubules and ryanodine receptors in the sarcoplasmic reticulum becomes defective, partially because of the decreased expression of a T-tubule–sarcoplasmic reticulum anchoring protein, junctophilin-2. MicroRNA (miR)-24, a junctophilin-2 suppressing miR, is upregulated in hypertrophied and failing cardiomyocytes. Objective: To test whether miR-24 suppression can protect the structural and functional integrity of L-type Ca 2+ channel–ryanodine receptor signaling in hypertrophied cardiomyocytes. Methods and Results: In vivo silencing of miR-24 by a specific antagomir in an aorta-constricted mouse model effectively prevented the degradation of heart contraction, but not ventricular hypertrophy. Electrophysiology and confocal imaging studies showed that antagomir treatment prevented the decreases in L-type Ca 2+ channel–ryanodine receptor signaling fidelity/efficiency and whole-cell Ca 2+ transients. Further studies showed that antagomir treatment stabilized junctophilin-2 expression and protected the ultrastructure of T-tubule–sarcoplasmic reticulum junctions from disruption. Conclusions: MiR-24 suppression prevented the transition from compensated hypertrophy to decompensated hypertrophy, providing a potential strategy for early treatment against heart failure.
Atlas of Gastrointestinal Cytodiagnosis
Authors: Tilde S. Kline
Journal: JAMA (1970)

<b>Exfoliative Cytopathology</b>, by Zuher M. Naib, 398 pp, 155 illus, $15, Boston: Little, Brown &amp; Co., 1970. Two texts on cytodiagnosis have recently been published—<i>Atlas of Gastrointestinal Cytodiagnosis</i>, by Henning and Witte, translated by Nieburgs, and<i>Exfoliative Cytopathology</i>, by Naib. The volume on gastroenterology has limited appeal. Even though much of the photography is unremarkable, there is considerable interest in the comparison of microscopic techniques used to examine the entire gastrointestinal tract; included are photographs of the Papanicolaou stain, Pappenheim stain, intravital staining with atabrine, a fluorescent dye, and phase-contrast microscopy. Cytodiagnosis, endoscopy, and roentgenologic findings are also compared, as well as various collection techniques. Of much wider appeal is<i>Exfoliative Cytopathology</i>. In the preface, Dr. Naib states that he has "made special effort to present, in the simplest and most concise manner, the basic systemic knowledge needed for interpretation" of cytology. He has completely fulfilled his aim. This
Pay-for-Performance and Accountability
Authors: Marcy Zwelling
Journal: Annals of Internal Medicine (2007)

Letters5 June 2007Pay-for-Performance and AccountabilityMarcy Zwelling, MDMarcy Zwelling, MDFrom Los Alamitos, CA 90720.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-11-200706050-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I became a cynic early on when it came to the “golden rule.” My father's interpretation (“He who hath the gold, rules”) seemed suitable in the world where I grew up. The emergence of pay-for-performance as described by Rowe (1) is the medical version of my dad's golden rule.Medicare emerged in 1965, and the patient–physician relationship dissolved into the patient–fiduciary (health plan)–physician cooperative. As the cost of care increased (as one would only expect in any first dollar coverage system), the fiduciary, often a for-profit corporation, needed to cut expenses while increasing market share to maintain ...Reference1. Rowe JW. Pay-for-performance and accountability: related themes in improving health care. Ann Intern Med. 2006;145:695-9. [PMID: 17088584] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Los Alamitos, CA 90720.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPay-for-Performance and Accountability: Related Themes in Improving Health Care John W. Rowe Pay-for-Performance and Accountability John W. Rowe Pay-for-Performance and Accountability Christine K. Cassel Pay-for-Performance and Accountability Christine A. Sinsky Pay-for-Performance and Accountability Mahesh Krishnamurthy Metrics 5 June 2007Volume 146, Issue 11Page: 824KeywordsConflicts of interestHealth careHealth information technologyHealth statisticsLibrariesMedicarePatient advocacy ePublished: 5 June 2007 Issue Published: 5 June 2007 CopyrightCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Adverse reactions to D-penicillamine after gold toxicity.
Authors: M J Dodd, I D Griffiths, M Thompson
Journal: BMJ (1980)

The incidence of adverse reactions to D-penicillamine in 155 patients with rheumatoid arthritis was analysed and compared with their history of adverse reactions to gold. Out of 125 patients who took only D-penicillamine, 45 developed side effects from the drug, whereas of 27 patients with a history of gold toxicity, 18 also reacted adversely to D-penicillamine. All patients who took D-penicillamine within six months after an adverse reaction to gold developed side effects from D-penicillamine. Fourteen patients developed similar adverse reactions to D-penicillamine and gold, and the interval between treatments in this group was significantly shorter (p less than 0.01) than in those who developed either differing adverse reactions to both drugs or no reaction to D-penicillamine after treatment with gold. An interval exceeding six months between treatment with gold and treatment with D-penicillamine in patients who have developed adverse reactions to gold apparently reduces the risk of adverse reactions to D-penicillamine.
1338 WHOLE GENOME EXPRESSION PROFILE DEFINES DIFFERENTIALLY EXPRESSED GENES IN HIV/HCV-COINFECTED PATIENTS ACCORDING TO PEGIFNA/RBV TREATMENT OUTCOME AND TO IL28B GENOTYPE
Authors: N.I. Rallón, L.A. Lopez-Fernandez, C. Restrepo, M.I. Garcia, V. Soriano, J.M. Benito
Journal: Journal of Hepatology (2011)
Intentional weight loss and mortality among overweight individuals with diabetes.
Authors: D F Williamson, T J Thompson, M Thun, D Flanders, E Pamuk, T Byers
Journal: Diabetes Care (2000)

OBJECTIVE: To estimate the effect of intentional weight loss on mortality in overweight individuals with diabetes. RESEARCH DESIGN AND METHODS: We performed a prospective analysis with a 12-year mortality follow-up (1959-1972) of 4,970 overweight individuals with diabetes, 40-64 years of age, who were enrolled in the American Cancer Society's Cancer Prevention Study I. Rate ratios (RRs) were calculated, comparing overall death rates, and death from cardiovascular disease (CVD) or diabetes in individuals with and without reported intentional weight loss. RESULTS: Intentional weight loss was reported by 34% of the cohort. After adjustment for initial BMI, sociodemographic factors, health status, and physical activity, intentional weight loss was associated with a 25% reduction in total mortality (RR = 0.75; 95% CI 0.67-0.84), and a 28% reduction in CVD and diabetes mortality (RR = 0.72; 0.63-0.82). Intentional weight loss of 20-29 lb was associated with the largest reductions in mortality (approximately 33%). Weight loss &amp;gt;70 lb was associated with small increases in mortality CONCLUSIONS: Intentional weight loss was associated with substantial reductions in mortality in this observational study of overweight individuals with diabetes.
Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein
Authors: Nripesh Dhungel, Simona Eleuteri, Ling-bo Li, Nicholas J. Kramer, Justin W. Chartron, Brian Spencer, Kori Kosberg, Jerel Adam Fields, Klodjan Stafa, Anthony Adame, Hilal Lashuel, Judith Frydman, Kang Shen, Eliezer Masliah, Aaron D. Gitler
Journal: Neuron (2014)
Ethnic Differences in the Prevalence of Anencephaly and Spina Bifida in Boston, Massachusetts
Authors: Lechaim Naggan, Brian MacMahon
Journal: New England Journal of Medicine (1967)

IT has been reported that the prevalence rate of anencephaly and spina bifida is very high in Ireland1 , 2 and very low in the Jewish population of the United States.3 These observations prompted the present study of differences in rates between ethnic groups in Boston, Massachusetts. The large population of Irish descent in Boston provides the basis for a study of the effect of migration; the substantial Jewish population allows a re-examination of the earlier observations made in Rhode Island, where the Jewish population is quite small.Embryologic4 and epidemiologic similarities,3 , 5 in particular the tendency for both malformations to occur within . . .
Workmen's Compensation Medicine
Authors: William B. Whiting
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Workmen's compensation medicine is assuming more prominence in the practice of medicine. This results from the federal government's recent entrance into the field with the passage of the Williams-Steiger Occupational Safety and Health Act of 1970 (OSHA) (public law 91-596). A part of this Act establishes a "National Commission on State Workmen's Compensation Laws," appointed by the President (public law 91-596, sect 27). This commission reported to the congress in July of 1972, following a 12-month study of workmen's compensation throughout the United States. The Commission recommended federal standards that approached, if they did not actually exceed, the highest standards existing in any of the states prior to this study. Examples the Commission gives of the "essential elements of workmen's compensation" are the following: Compulsory coverage... [for all employees] No occupational or numerical exemptions to coverage Full coverage of work-related diseases Full medical and physical rehabilitation services
Re: Todd M. Morgan, Dominic Tang, Kelly L. Stratton, et al. Preoperative Nutritional Status Is an Important Predictor of Survival in Patients Undergoing Surgery for Renal Cell Carcinoma. Eur Urol 2011;59:923–8
Authors: Sabine Brookman-May, Maximilian Burger, Wolf F. Wieland, Matthias May
Journal: European Urology (2011)
Dissolution of cholesterol gall stones using methyltertbutyl ether: a safe effective treatment.
Authors: J McNulty, A Chua, J Keating, S Ah-Kion, D G Weir, P W Keeling
Journal: Gut (1991)

Methyltertbutyl ether (MTBE) administered by percutaneous transhepatic catheter rapidly dissolves radiolucent cholesterol gall bladder stones. However, complete dissolution and clearance of non-cholesterol debris is essential to prevent recurrence. In this study we analysed 25 consecutive patients with reference to efficacy and recurrence based on the presence or absence of non-cholesterol stone fragments after dissolution. Placement of the catheter was successful in 24 patients, one patient requiring cholecystectomy for bile peritonitis. MTBE was infused and aspirated continuously, four to six cycles per minute, resulting in rapid stone dissolution (median six hours; range 4-23 hours for solitary stones and median seven hours, range 4-30 hours for multiple stones). In 18 patients who had complete dissolution, four (22%) had recurrent stones within six to 18 months. Five patients had residual debris which failed to clear completely despite bile acid treatment. One patient with an incomplete rim of calcium in a large stone did not respond to MTBE treatment. A further patient required cholecystectomy for symptomatic recurrence. There were no serious side effects observed. MTBE treatment is a rapid, safe, and effective treatment for patients who refuse surgery or who for medical reasons cannot undergo cholecystectomy. The results of this study confirm that complete dissolution of all fragments is essential and may prevent recurrence.
A Retrospective Comparison Study of Docetaxel and Paclitaxel for Previously Treated Chemotherapy for Esophageal Cancer
Authors: T. Shirakawa, K. Kato, H. Shoji, Y. Honma, S. Iwasa, A. Takashima, N. Okita, T. Hamaguchi, Y. Yamada, Y. Shimada
Journal: Annals of Oncology (2013)
The hemodynamic effects of cardiac tamponade: mainly the result of atrial, not ventricular, compression.
Authors: N O Fowler, M Gabel
Journal: Circulation (1985)

We studied the hemodynamic effects of surgically induced regional cardiac tamponade in anesthetized dogs. Tamponade restricted to either the right or the left ventricle was compared with tamponade of either ventricle and both atria. Intrapericardial pressures were elevated to approximately 20 mm Hg. With tamponade of the right ventricle alone, aortic pressure rose from 161 +/- 3.8 to 164 +/- 3.4 mm Hg (p greater than .05) and cardiac output fell from 149.4 +/- 16.1 to 134.9 +/- 11.9 ml/kg/min (p greater than .05). However, tamponade of the right ventricle plus both atria decreased mean aortic pressure from 152.5 +/- 3.6 to 115.9 +/- 8.7 mm Hg (p less than .01) and cardiac output fell from 118 +/- 14.8 to 38.9 +/- 4.8 ml/kg/min (p less than .01). With tamponade of the left ventricle alone, aortic mean pressure changed significantly from 158.5 +/- 6.1 (control) to 148.9 +/- 5.0 mm Hg (tamponade) (p less than .05) and cardiac output was 135.5 +/- 28.3 (control) and 111 +/- 24.7 ml/kg/min (tamponade) (p greater than .05). However, when the atria were included, mean aortic pressure fell significantly more from 155.5 +/- 5.4 to 105.5 +/- 10.4 mm Hg (p less than .01) and cardiac output fell from 142.2 +/- 16 to 47.8 +/- 6.4 ml/kg/min (p less than .01). Atrial pressure rose when the atria were included, but not with tamponade of the left ventricle alone. Right but not left atrial pressure rose slightly with isolated right ventricular tamponade. We conclude that the principal hemodynamic effects of cardiac tamponade are not the result of compression of either the right or the left ventricle, but are the consequence of compression of the atria and/or the venae cavae and the pulmonary veins.
Renal Effects of Urography in Diabetes Mellitus
Authors: Brajesh N. Agarwal, Franklin Cabebe, Cynthia Mccormick
Journal: Annals of Internal Medicine (1975)

Comments1 December 1975Renal Effects of Urography in Diabetes MellitusBRAJESH N. AGARWAL, M.D., FRANKLIN CABEBE, M.D., CYNTHIA MCCORMICKBRAJESH N. AGARWAL, M.D.Search for more papers by this author, FRANKLIN CABEBE, M.D.Search for more papers by this author, CYNTHIA MCCORMICKSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-6-902_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent paper, "Acute Renal Failure After Excretory Urography in Diabetic Patients" by Diaz-Buxo and associates (Ann Intern Med 83:155-158, 1975), prompts us to report a similar case that we have seen at our institution.A 58-year-old black woman with diagnoses of rheumatic heart disease, aortic stenosis, and congestive heart failure was admitted to the Medical College of Pennsylvania Hospital on 9 August 1975 for cardiac evaluation. She had a 30-year history of diabetes mellitus, for which she was taking insulin. Her only other medications were digoxin and furosemide. At admission her blood urea nitrogen (BUN) level... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BRAJESH N. AGARWAL, M.D.; FRANKLIN CABEBE, M.D.; CYNTHIA MCCORMICK PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySouthwestern Internal Medicine Conference: Renal Failure Following Radiologic ProceduresSouthwestern Internal Medicine Conference: Drug Therapy in the Management of Acute Renal FailureRadiologic Contrast-Induced NephropathyLow risk of contrast media-induced acute renal failure in nonazotemic type 2 diabetes mellitusRenal function after high dose urography in patients with renal failureExacerbation of diabetic renal failure following intravenous pyelography 1 December 1975Volume 83, Issue 6 Page: 902-902 Keywords Acute renal failure Blood urea nitrogen Cardiovascular therapy Diabetes mellitus Heart diseases Heart failure Insulin Pyelography Stenosis ePublished: 1 December 2008 Issue Published: 1 December 1975 PDF downloadLoading ...
Use long acting 2 agonists only when asthma cannot be controlled otherwise
Authors: J. Hasford
Journal: BMJ (2013)

When reviewing the value of long acting β2 agonists in the treatment of asthma,1 Currie and colleagues did not properly report the results of one of the major studies, the Salmeterol Multi-centre Asthma Research Trial (SMART).2

When salmeterol was approved in the US in 1994, the Food and Drug Administration asked the manufacturer to run a large scale placebo controlled safety trial owing to accumulating concerns about the …
A Randomized Phase II Study of a Combination of Docetaxel and S-1 versus Docetaxel Monotherapy in Patients with Non-small Cell Lung Cancer Previously Treated with Platinum-Based Chemotherapy: Results of Okayama Lung Cancer Study Group (OLCSG) Trial 0503
Authors: Yoshihiko Segawa, Katsuyuki Kiura, Katsuyuki Hotta, Nagio Takigawa, Masahiro Tabata, Keitaro Matsuo, Hiroshige Yoshioka, Hidetoshi Hayashi, Haruyuki Kawai, Keisuke Aoe, Tadashi Maeda, Hiroshi Ueoka, Mitsune Tanimoto
Journal: Journal of Thoracic Oncology (2010)
Phase III Study of Concurrent Chemoradiotherapy Versus Radiotherapy Alone for Advanced Nasopharyngeal Carcinoma: Positive Effect on Overall and Progression-Free Survival
Authors: Jin-Ching Lin, Jian-Sheng Jan, Chen-Yi Hsu, Wen-Miin Liang, Rong-San Jiang, Wen-Yi Wang
Journal: Journal of Clinical Oncology (2003)

Purpose: Nasopharyngeal carcinoma (NPC) is a radiosensitive and chemosensitive tumor. This randomized phase III trial compared concurrent chemoradiotherapy (CCRT) versus radiotherapy (RT) alone in patients with advanced NPC. Patients and Methods: From December 1993 to April 1999, 284 patients with 1992 American Joint Committee on Cancer stage III to IV (M0) NPC were randomly allocated into two arms. Similar dosage and fractionation of RT was administered in both arms. The investigational arm received two cycles of concurrent chemotherapy with cisplatin 20 mg/m 2 /d plus fluorouracil 400 mg/m 2 /d by 96-hour continuous infusion during the weeks 1 and 5 of RT. Survival analysis was estimated by the Kaplan-Meier method and compared by the log-rank test. Results: Baseline patient characteristics were comparable in both arms. After a median follow-up of 65 months, 26.2% (37 of 141) and 46.2% (66 of 143) of patients developed tumor relapse in the CCRT and RT-alone groups, respectively. The 5-year overall survival rates were 72.3% for the CCRT arm and 54.2% for the RT-only arm (P = .0022). The 5-year progression-free survival rates were 71.6% for the CCRT group compared with 53.0% for the RT-only group (P = .0012). Although significantly more toxicity was noted in the CCRT arm, including leukopenia and emesis, compliance with the combined treatment was good. The second cycle of concurrent chemotherapy was refused by nine patients and was delayed for ≥ 1 week for another nine patients. There were no treatment-related deaths in either arm. Conclusion: We conclude that CCRT is superior to RT alone for patients with advanced NPC in endemic areas.
High glucose, nitric oxide, and adenosine: a vicious circle in chronic hyperglycaemia?
Authors: Assunta Pandolfi, Natalia Di Pietro
Journal: Cardiovascular Research (2010)

Diabetes mellitus is characterized by accelerated atherosclerosis and increased risk of cardiovascular disease. Metabolic factors associated with the diabetic state itself, such as hyperglycaemia, are likely to contribute to the increased cardiovascular risk in diabetic patients.1 Endothelial dysfunction is recognized as a major cardiovascular risk factor, being a key determinant of atherosclerosis.2 Among the number of factors involved in maintaining proper vascular wall homeostasis, nitric oxide (NO) is of pivotal relevance in guaranteeing physiological endothelial function.3 In fact, impaired NO synthesis and/or availability results in endothelial dysfunction,4 thus promoting the development of vascular damage. Although it has been demonstrated that diabetes is associated with endothelial dysfunction, and it is known that endothelium-dependent vasodilation is significantly impaired in diabetic patients,5 it is still a matter of controversy whether and in which way the imbalance of glucose metabolism might affect NO synthesis and bioavailability.5,6 The question of whether the impaired endothelium-mediated vasodilation observed in diabetic patients suggests a deficit in NO synthesis in these subjects arises from several studies demonstrating that in vitro elevated glucose concentrations can up-regulate the endothelial NO synthase (eNOS) gene and protein expression and stimulate NO production in both animal7 and human cells.8 Likewise, primary cultures of human umbilical vein endothelial cells (HUVEC) obtained from gestational diabetic pregnancies, as well as HUVEC cultured in high glucose, exhibit increased synthesis of NO9 and reduced uptake of the endogenous nucleoside vasodilator, adenosine.10, … 

*Corresponding author. Tel/fax: +39 0871 541425, Email: pandolfi{at}unich.it
A Randomized Trial of Tacrolimus versus Tacrolimus and Prednisone for the Maintenance of Disease Remission in Noninfectious Uveitis
Authors: Richard W.J. Lee, Rosemary Greenwood, Hazel Taylor, Radgonde Amer, Sabine Biester, Jarka Heissigerova, John V. Forrester, Andrew D. Dick
Journal: Ophthalmology (2012)
Intracoronary gene transfer of fibroblast growth factor–5 increases blood flow and contractile function in an ischemic region of the heart
Authors: Frank J. Giordano, Peipei Ping, M. Dan McKirnan, Shiro Nozaki, Anthony N. Demaria, Wolfgang H. Dillmann, Odile Mathieu-Costello, H. Kirk Hammond
Journal: Nature Medicine (1996)