tbuckley/cabot-search huggingface dataset:
Abstract 1151: microRNAs affect therapeutic sensitivity of human gliobastoma to temozolomide
Authors: Cristina Quintavalle, Michela Garofalo, Giulia Romano, Margherita Iaboni, Elvira Donnarumma, Gerard Nuovo, Carlo M. Croce, Gerolama Condorelli
Journal: Cancer Research (2011)

Abstract Glioma is among the most deadly type of cancer. In spite of the enormous improvements made the prognosis of malignant glioma has remained poor over the last decade. Many glial-derived tumors seem to be particularly resistant to apoptosis following DNA damage. MicroRNAs (miRNA) represent a novel class of small RNAs that might play a fundamental role in tumorigenesis, cell proliferation, migration and apoptosis. Temozolomide is an alkylating agent used in glioma patients that alkylates/methylates DNA. The alkylation damages the DNA and triggers the death of tumor cells. O6-methylguanine DNA methyltransferase (MGMT) is a DNA repair enzyme which removes DNA adducts. MGMT activity is frequently lost in glioblastoma in the presence of CpG island hypermethylation in the promoter region. The methylation status of the MGMT promoter is considered to be indicative of a good outcome in patients with malignant gliomas. However, in some studies the correlation between MGMT promoter methylation and MGMT expression levels are contradictory. Other possible mechanisms of MGMT modulation should exist. Therefore, we investigated the role of miRs on the regulation of MGMT expression levels. We analyzed temozolomide sensitivity of human glioma cell lines, T98G and U87MG. T98G resulted resistant to temozolomide, whereas U87MG cells were sensitive. Through a microarray analysis we provided evidences that miR-221/222 are differentially expressed in U87MG compared to T98G cells. Bioinformatics analysis through RNA Hybrid indicated a possible match between MGMT 3’UTR and miR-221/222. Luciferase assay confirmed that miR-221/222 are capable to bind the 3’UTR of MGMT and to impair its mRNA translation. Western blot and RT-PCR analysis upon synthetic pre-miR-221/222 transfection of T98G cells indicated that MGMT levels were significantly decreased. At the contrar, the transfection of U87MG cells with anti-miR-221/222 induced an increase of MGMT levels. Therefore this data indicate that MGMT is a new target of miRs -221/222. The analysis of cell death with MTT, Annexin V and colony assay upon temozolomide treatment in cells whose miR-221/222 levels were modulated, demonstrated an important role of those miRs in temozolomide sensitivity. All these data indicate that miR-221/222 might represent a new strategy for regulation of MGMT expression levels and thus temozolomide sensitivity and an improvement in chemotherapy strategy for glioblastoma patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1151. doi:10.1158/1538-7445.AM2011-1151
Measurement of Effective Renal Plasma Flow With Sodium Iodohippurate I 131
Authors: Richard D. Wagoner, W. Newlon Tauxe, Frank T. Maher, James C. Hunt
Journal: JAMA (1964)

A technique for measuring effective renal plasma flow based on a single injection of sodium iodohippurate I 131 was compared with para-aminohippuric acid clearance determined simultaneously in 25 patients. On the average, the clearance by the single-injection technique was about 19 ml (5%) less than that by the standard procedure. The results indicate that there is a good correlation between the methods. It is suggested that further study with this simpler technique may prove it to be a reliable substitute for the more cumbersome standard method.
Note on Malta Fever
Authors: D. Bruce
Journal: BMJ (1891)

times daily.Not only have I not had any deaths, but I have met with no accident of any kind.I have not once had to do artificial respiration or to pull forward the tongue.Neither lhave I had to interrupt an operation in order to ward off any accident due to cliloroformisation.There is no element wlhatever either of luck or of chance about these results.Any surgeon canl administer chloroform without risk who will take the trouble to assure himself that the patient's breathing is normal aind regular throughout the administra- tion, and to stop the inhalation in good time, that is, directly full anaesthesia is produced.Statistics such as those; of Dr. Julliard and Mr. Roger Williams, which are intended to show the danger of chloroform, are, as my table proves, susceptible of a very different interpretation.If they help to prove any- thing, it is that no anaesthetic is absolutely safe except chlo- roform administered on Syme's principles, and the more proof we have of this kind the better.
DEFINITE STENT THROMBOSIS UP TO 8 YEARS FOLLOW-UP IN REAL-WORLD PATIENTS UNDERGOING DRUG-ELUTING STENT IMPLANTATION
Authors: Ricardo A. Costa, Amanda Sousa, Adriana Moreira, J. Ribamar Costa, Manuel Cano, Galo Maldonado, Luiz A. Mattos, Fausto Feres, Cantídio Campos, Mariana T. Carballo, Otavio Berwanger, J. Eduardo Sousa
Journal: Journal of the American College of Cardiology (2011)
The child and his symptoms; a psychosomatic approach.
Authors: Marjorie C. Meehan
Journal: JAMA (1963)

<b>The significance of affective symptoms in old age; a follow-up study of one hundred patients. Institute of Psychiatry. Maudsley Monographs No 10.</b>By Felix Post. 107 p. $7. Oxford University Press, 417 5th Ave, New York 16, 1962 From England come two interesting books dealing with opposite ends of the life cycle. Apley and MacKeith, both pediatricians, present a delightful guide to help doctors understand and care for children, while Post, a physician at Bethlem Royal and Maudsley Hospitals, offers a careful investigation of depression in the aged. Although the emphasis in<i>The Child and His Symptoms</i>is on the psychosomatic aspect of children's ills, a number of common pediatric problems are reviewed, with differential diagnoses of organic and emotionally caused conditions. Apley and MacKeith particularly bring out the overlapping and interweaving of physical and mental problems and discuss their simultaneous handling. Most of the complaints commonly brought to doctors
Abstract IA28: Haploinsufficiency in cancer
Authors: Teresa Davoli, Nicole L. Solimini, Natalya N. Pavlova, Qikai Xu, Kristen Mengwasser, Laura M. Sack, Anthony C. Liang, Michael R. Schlabach, Ji Luo, Anna E. Burrows, Anthony N. Anselmo, Mamie Z. Li, Stephen J. Elledge
Journal: Cancer Research (2013)

Abstract Breast cancer is a collection of diseases with distinct clinical behaviors and underlying genetic causes. We have searched genetically for genes that have cancer relevant phenotypes including genes that alter cellular proliferation, cellular transformation, cell survival, cellular senescence, and genes that are essential for the proliferation of cancer cells. We have approached this by the generation of libraries of shRNAs for loss of function experiments and libraries of ORFs for gain of function experiments. We will discuss these technologies and how they can be applied to the functional dissection of genes important for breast cancer. Using these new technologies we have identified new oncogenes and tumor suppressors. We find that tumor cells selectively delete negative growth regulators and suggest that the deletion of clusters of these genes may drive tumorigenesis by haploinsufficiency. These recurrent deletions also avoid deletion of one copy of many essential genes through haploinsufficiency. We put forward the Cancer Gene Island model that postulates that tumors select for hemizygous loss of islands of gene enriched in negative regulators of proliferation and depleted in essential genes to promote tumor cell proliferation through cumulative haploinsufficiency. Citation Format: Teresa Davoli, Nicole L. Solimini, Natalya N. Pavlova, Qikai Xu, Kristen Mengwasser, Laura M. Sack, Anthony C. Liang, Michael R. Schlabach, Ji Luo, Anna E. Burrows, Anthony N. Anselmo, Mamie Z. Li, Stephen J. Elledge. Haploinsufficiency in cancer. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr IA28.
Biliary excretion of iron from hepatocyte lysosomes in the rat. A major excretory pathway in experimental iron overload.
Authors: G D LeSage, L J Kost, S S Barham, N F LaRusso
Journal: Journal of Clinical Investigation (1986)

In these experiments, we assessed the role of hepatocyte lysosomes in biliary excretion of iron. We loaded rats with iron by feeding 2% carbonyl iron and collected bile for 24 h via bile fistulae from iron-loaded and control rats. In additional rats, bile was collected before and after the administration of colchicine. Rats were then killed and their livers were homogenized and fractionated for biochemical analyses or processed for electron microscopy and x-ray microanalysis. Inclusion of 2% carbonyl iron in the diet caused a 45-fold increase (P less than 0.001) in hepatic iron concentration compared with controls (1,826 +/- 159 vs. 38 +/- 6.7 micrograms/g liver, mean +/- SE). Electron microscopy with quantitative morphometry and x-ray microanalysis showed that the excess iron was sequestered in an increased number of lysosomes concentrated in the pericanalicular region of the hepatocyte. Iron loading was also associated with a twofold increase in biliary iron excretion (4.06 +/- 0.3 vs. 1.75 +/- 0.1 micrograms/g liver/24 h; P less than 0.001). In contrast, the biliary outputs of three lysosomal enzymes were significantly lower (P less than 0.0005) in iron-loaded rats compared with controls (mean +/- SE) expressed as mU/24 h/g liver: N-acetyl-beta-glucosaminidase, 26.7 +/- 4.6 vs. 66.2 +/- 13.4; beta-glucuronidase, 10.1 +/- 1.3 vs. 53.2 +/- 17.9; beta-galactosidase, 8.9 +/- 1.0 vs. 15.4 +/- 2.3. In iron-loaded rats but not in controls, biliary iron excretion was coupled to the release into bile of each of the three lysosomal hydrolases as assessed by linear regression analysis (P less than 0.001). In contrast, no relationships were found between biliary iron excretion and the biliary outputs of a plasma membrane marker enzyme (alkaline phosphodiesterase I) or total protein. After administration of colchicine, there was a parallel increase in biliary excretion of iron and lysosomal enzymes in iron-loaded rats, but not controls. We interpret these data to indicate that, in the rat, biliary iron excretion from hepatocyte lysosomes is an important excretory route for excess hepatic iron.
Dizziness and Vertigo: Diagnosis and Treatment
Authors: Paul H. Ward
Journal: JAMA (1967)

This book is a collaborative effort by contributors from the various specialty fields who deal with dizzy patients. An attempt is made to survey and classify our present knowledge of the vestibular system from the viewpoints of otolaryngology, neurosurgery, neurology, internal medicine, dentistry, allergy, ophthalmology, and psychiatry. The editor has written slightly under half of the chapters in an effort to introduce some cohesion to the varied approaches of the contributors. The usual attributes and weaknesses that accompany an effort of this nature are evident. The chapters vary from the presentation of excellent basic experimental data to pseudoscientific incongruity. The text is replete with aphorisms, case reports, and conflicting literature citations. Illustrations are frequent and used to maximum advantage in some chapters, while in others they are inconsequential. A strong feature is the excellent list of references at the end of each chapter. The book fails to achieve the editor's
Sex Differences in Myocardial Infarction and Coronary Deaths in the Scottish MONICA Population of Glasgow 1985 to 1991
Authors: Hugh Tunstall-Pedoe, Caroline Morrison, Mark Woodward, Bridie Fitzpatrick, Graham Watt
Journal: Circulation (1996)

Background Scottish MONICA used medical and medicolegal records and World Health Organization MONICA Project criteria to register coronary events in 25- to 64-year-old residents of the high-incidence area of north Glasgow from 1985 to 1991. Methods and Results Age-standardized data from 3991 episodes of nonfatal definite myocardial infarction and coronary deaths in men (mean age, 55.5 years) were compared with 1551 in women (57.0 years). Many results, such as the overall 28-day fatality rates of 49.8% in men and 48.5% in women, showed insignificant differences. However, 74.3% of deaths in men occurred out of hospital versus 67.8% in women ( P =.0004). After admission to hospital, fatality rates in women were 14% higher ( P =.07) and after admission to coronary care, 22% higher ( P =.04). Women were more often widowed. Fewer had a history of previous myocardial infarction, but the prevalence of angina pectoris, of smoking, and of chest pain in the attack was the same as in men; more had shock, syncope, and breathlessness. More consulted a doctor before admission to hospital, which delayed their coming under care. More men had ECG Q-wave progression, and more women had smaller ECG changes. This, and marginally reduced chances of direct admission to coronary care, of thrombolysis, of aspirin, and of β-blockers, did not explain women’s excess hospital fatality. Conclusions Acute coronary events appear to be recognized and treated fairly equally in men and women 25 to 64 years old in Glasgow, so differences are small but subtle. More men die suddenly out of hospital; the reason why more women die after arrival may be because the equivalent number of men have already died outside.
Sports expert defends "chocolate for equipment" scheme
Authors: A. Elliot
Journal: BMJ (2003)

A controversial, government endorsed campaign to tackle obesity by encouraging children to exchange chocolate bar wrappers for sports equipment is “showing positive results,” a former government adviser has claimed.

Dr Sue Campbell, now chief executive of the Youth Sports Trust, said research suggested that the Cadbury Get Active campaign was not making children eat more chocolate.

Giving evidence at the health committee inquiry last week, Dr Campbell said, “Early signs from an independent …
Patients’ Unrealistic Hopes for Cancer Trial Benefits May Hinder Consent
Authors: Bridget M. Kuehn
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NIH, CDC Budget Squeeze
Authors: Mike Mitka
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The TRAF6 binding molecule p62/SQSTM1 is a critical regulator of inflammatory bone destruction
Authors: A Korb, A Hillmann, S Burgis, G Kollias, S Hermann, M Schafers, T Pap, T Weide, A Gessner, H Pavenstadt
Journal: Annals of the Rheumatic Diseases (2010)

The activation of nuclear factor κB (NFκB) via RANK is essential in regulating osteoclastogenesis. Under inflammatory conditions this process is enhanced by cytokines such as tumour necrosis factor α (TNFα). P62/SQSTM1 directly modulates these pathways through complex formation with TRAF6, aPKCs and ubiquitin. However, the role of p62/SQSTM1 in regulating bone turnover under inflammatory conditions, and specifically the role of the signal transduction domains of p62/SQSTM1, is unclear.

Mice were generated that carry a shortened but functional mutant of p62 with …
Plasma Levels of Cellular Fibronectin in Diabetes
Authors: Suzan D.J.M. Kanters, Jan-Dirk Banga, Ale Algra, Rini C.J.M. Frijns, Jaap J. Beutler, Rob Fijnheer
Journal: Diabetes Care (2001)

OBJECTIVE— Cellular fibronectin is an endothelium-derived protein involved in subendothelial matrix assembly. Elevated plasma levels of cellular fibronectin therefore reflect loss of endothelial cell polarization or injury to blood vessels. Consequently, elevated plasma levels of circulating cellular fibronectin have been described in clinical syndromes with vascular damage, although not in diabetes or atherosclerosis. RESEARCH DESIGN AND METHODS— We determined fibronectin levels in 52 patients with type 1 diabetes, 50 patients with type 2 diabetes, 54 patients with a history of ischemic stroke, 23 patients with renal artery stenosis, and 64 healthy subjects. RESULTS— Circulating cellular fibronectin was significantly elevated in patients with diabetes (4.3 ± 2.8 μg/ml) compared with patients with ischemic stroke (2.0 ± 0.9 μg/ml), patients with renovascular hypertension (1.7 ± 1.1 μg/ml), and healthy subjects(1.4 ± 0.6 μg/ml). Patients with diabetes and at least one cardiovascular risk factor had an almost 2.5-fold increase in cellular fibronectin compared with diabetic subjects without such a risk factor. In multivariate regression analysis, higher triglycerides, current or past cigarette smoking, and higher urinary albumin excretion were independently associated with an increase in circulating cellular fibronectin in diabetes. CONCLUSIONS— These results suggest that circulating cellular fibronectin may be a marker protein for endothelial cell activation,especially in diabetes. Prospective studies are needed to explore this possibility.
93 HCV genotype 2 and 3 can be cured by PEG-IFN-alfa-2B and RBV for 12 wks: A randomized controlled study
Authors: A. Mangia, N. Minerva, G.L. Ricci, M. Romano, V. Carretta, M. Persico, D. Bacca, F. Spirito, F. Vinelli, M. Annese, A. Giangaspero, G. Scotto, A. Andriulli
Journal: Journal of Hepatology (2004)
Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury.
Authors: Y Cheng, M Deshmukh, A D'Costa, J A Demaro, J M Gidday, A Shah, Y Sun, M F Jacquin, E M Johnson, D M Holtzman
Journal: Journal of Clinical Investigation (1998)

Programmed cell death (apoptosis) is a normal process in the developing nervous system. Recent data suggest that certain features seen in the process of programmed cell death may be favored in the developing versus the adult brain in response to different brain injuries. In a well characterized model of neonatal hypoxia-ischemia, we demonstrate marked but delayed cell death in which there is prominent DNA laddering, TUNEL-labeling, and nuclei with condensed chromatin. Caspase activation, which is required in many cases of apoptotic cell death, also followed a delayed time course after hypoxia-ischemia. Administration of boc-aspartyl(OMe)-fluoromethylketone, a pan-caspase inhibitor, was significantly neuroprotective when given by intracerebroventricular injection 3 h after cerebral hypoxia-ischemia. In addition, systemic injections of boc-aspartyl(OMe)-fluoromethylketone also given in a delayed fashion, resulted in significant neuroprotection. These findings suggest that caspase inhibitors may be able to provide benefit over a prolonged therapeutic window after hypoxic-ischemic events in the developing brain, a major contributor to static encephalopathy and cerebral palsy.
Association of HLA-A9 and HLA-B5 with Buerger's disease.
Authors: G A McLoughlin, C R Helsby, C C Evans, D M Chapman
Journal: BMJ (1976)

Eighteen patients who satisfied stringent criteria for the diagnosis of Buerger9s disease, healthy controls, and patients with atherosclerosis were tested for various HLA antigens. The incidence of HLA-A9 and HLA-B5 was significantly greater among those with Buerger9s disease. This finding supports the concept that Buerger9s disease is a distinct clinicopathological condition.
Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe
Authors: Kathryn E Holt, Stephen Baker, François-Xavier Weill, Edward C Holmes, Andrew Kitchen, Jun Yu, Vartul Sangal, Derek J Brown, John E Coia, Dong Wook Kim, Seon Young Choi, Su Hee Kim, Wanderley D da Silveira, Derek J Pickard, Jeremy J Farrar, Julian Parkhill, Gordon Dougan, Nicholas R Thomson
Journal: Nature Genetics (2012)
Hypertension Control — The Challenge of Patient Education
Authors: John B. Stokes, Gerald H. Payne, Theodore Cooper
Journal: New England Journal of Medicine (1973)

High blood pressure is the subject of a major educational campaign this year. This campaign, aimed at both professionals and the general public, is a Cooperative effort between the federal government, and a variety of nonfederal organizations.*This campaign was initiated because the public-health data clearly suggest that a reduction in morbidity and mortality from premature cardiovascular disease is achievable by treatment of hypertensive patients. Data from the National Health Examination Survey of 1962,1 extrapolated to the 1972 population, indicate that there are 23 million Americans with hypertension (blood pressure greater than 160 systolic, 95 diastolic). The same survey and . . .
Centenary of the synapse: from Sherrington to the molecular biology of the synapse and beyond
Authors: G.M. Shepherd, S.D. Erulkar
Journal: Trends in Neurosciences (1997)

Few concepts have meant more to neuroscience than the synapse, commonly understood to mean the junction between two excitable cells. The term was introduced by Charles Sherrington in 1897. The centenary of this event is an appropriate time to review the term's origins and utility. There are some surprises. The term didn't actually come from him. His concept was more functional than structural. The pioneering physiological and structural studies in the 1950s in fact did not lead to a rigorous definition. There is still confusion on how to define neurotransmitters. As molecular biological approaches are increasingly refining the concept of a fundamental synaptic unit, many types of neuronal interactions are appearing that do not fit with the synaptic concept. Are the neural circuits underlying behaviour strictly synaptic? In dealing with these questions, a longer perspective is useful for understanding how the term arose, how it has evolved to the present, and what kinds of challenges may be coming in the future.