Intractable Hiccups Associated with High-Dose Intravenous Methylprednisolone Therapy
Authors: BRUCE A. BAETHGE
Journal: Annals of Internal Medicine (1986)

Brief Reports1 January 1986Intractable Hiccups Associated with High-Dose Intravenous Methylprednisolone TherapyBRUCE A. BAETHGE, M.D., MARTIN D. LIDSKY, M.D.BRUCE A. BAETHGE, M.D.Search for more papers by this author, MARTIN D. LIDSKY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-1-58 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHigh-dose intravenous methylprednisolone has been used for management of many rheumatic diseases (1, 2). This therapy has been associated with complications including hyperglycemia, infection, exacerbation of hypertension, seizures, and sudden death (1-3). We report the cases of four patients who developed hiccups persisting longer than 24 hours after treatment with high-dose intravenous methylprednisolone.All patients were evaluated by a member of the Rheumatology Section at Baylor College of Medicine. The patients had established diagnoses and no history of prolonged hiccups. The indications for methylprednisolone therapy were the nephrotic syndrome, intense inflammatory peripheral arthropathy, and severe inflammatory dermatopathy. No patient had...References1. LIEBLINGLEIBMCLAUGHLIN MEK. Pulse methylprednisolone in rheumatoid arthritis: a double-blind cross-over trial. Ann Intern Med. 1981;94:21-6. LinkGoogle Scholar2. KIMBERLYLOCKSHINSHERMANMCDOUGALINMANCHRISTIAN RMRJRC. High-dose intravenous methylprednisolone pulse therapy in systemic lupus erythematosus. Am J Med. 1981;70:817-24. CrossrefMedlineGoogle Scholar3. GARRETTPAULUS RH. Complications of intravenous methylprednisolone pulse therapy [Abstract]. Arthritis Rheum. 1980;23:677. Google Scholar4. SOUADJIANCAIN JJ. Intractable hiccup: etiological factors in 220 cases. Postgrad Med. 1968;43:72-7. CrossrefMedlineGoogle Scholar5. NATHANLESHNERKELLER MRA. Intractable hiccups (singultus). Laryngoscope. 1980;90:1612-8. CrossrefMedlineGoogle Scholar6. DAVIS J. An experimental study of hiccup. Brain. 1970;93:851-72. CrossrefMedlineGoogle Scholar7. FELDMANTODTPORTER SJR. Effect of adrenocortical hormones on evoked potentials in the brain stem. Neurology. 1961;11:109-15. CrossrefMedlineGoogle Scholar8. RASTOGISINGHAL RR. Adrenocorticoids control 5-hydroxytryptamine metabolism in rat brain. J Neural Transm. 1978;42:63-71. CrossrefMedlineGoogle Scholar9. SCHULZE-DELRIEU K. Metoclopramide. N Engl J Med. 1981;305:28-33. CrossrefMedlineGoogle Scholar10. LEWITTBARTONPOSNER PNJ. Hiccup with dexamethasone therapy [Letter]. Ann Neurol. 1982;12:405-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BRUCE A. BAETHGE, M.D.; MARTIN D. LIDSKY, M.D.Affiliations: Baylor College of Medicine Veterans Administration Medical Center Houston, Texas▸Requests for reprints should be addressed to Martin D. Lidsky, M.D.; Department of Internal Medicine, Section of Rheumatology, Baylor College of Medicine, Veterans Administration Medical Center, 2002 Holcombe Boulevard; Houston, TX 77211. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by薬剤誘発性吃逆の3症例：原因薬剤と機序(Three cases of drug–induced hiccup: causative drugs and mechanisms)Neurological Complications of Primary Brain TumorsAntiemetic Corticosteroid Rotation from Dexamethasone to Methylprednisolone to Prevent Dexamethasone-Induced Hiccup in Cancer Patients Treated with Chemotherapy: A Randomized, Single-Blind, Crossover Phase III TrialSignes et symptômes de la sclérose en plaquesHoquet induit par les glucocorticoïdesManagement of Intractable HiccupsIntractable hiccup caused by spinal cord lesions in demyelination diseaseTransient Hiccups Associated with Oral DexamethasoneCorticosteroid Rotation to Alleviate Dexamethasone-Induced Hiccup: A Case Series at a Single InstitutionPersistent Hiccups After Interventional Pain Procedures: A Case Series and ReviewNeurological Complications of Chemotherapy in Lymphoma and Leukemia PatientsGabapentin in the Treatment of Hiccups in Patients With Advanced CancerSevere hiccups during chemotherapy: corticosteroids the likely culpritSupportive Care of Brain Tumor PatientsIntractable hiccups induced by high-dose intravenous methylprednisolone in a patient with multiple sclerosisFirst report of supraventricular tachycardia after intravenous pulse methylprednisolone therapy, with a brief review of the literatureCisplatin-Related Hiccups: Male Predominance, Induction by Dexamethasone, and Protection Against Nausea and VomitingUrbason Soluble 2375-03-3Iatrogenic-induced dysfunction of the neuromuscular respiratory systemPersistent Hiccups Associated With Intravenous Corticosteroid TherapyIntravenous pulses of methylprednisolone for systemic lupus erythematosusNeurologic complications of cancer therapyCentral Nervous System Complications of Cancer TherapyComplications des traitements locaux en rhumatologiePersistent Hiccup Associated with Thoracic Epidural InjectionBaclofen, A Treatment for Chronic HiccupSIDE EFFECTS OF IMMUNOSUPPRESSANT THERAPIES USED IN NEUROLOGYHiccups with high dose dexamethasone administrationMANAGEMENT OF COMPLICATIONS OF GLUCOCORTICOID THERAPYDrug-Induced HiccupsDer SchluckaufMedical Management of Cerebral MetastasesHiccups in terminal diseaseIV Steroid Treatment of Giant Cell ArteritisA Study of Adverse Effects of High-Dose Intravenous (Pulse) Methylprednisolone Therapy in Patients with Rheumatic DiseaseHigh-dose methylprednisolone sodium succinate as a single agent in relapsed childhood acute lymphoblastic leukaemiaSupportive Care of the Neuro-Oncology PatientHiccups (Singultus): Review and approach to managementAdverse Effects of Drugs on the Respiratory MusclesLe hoquet: à la (re)découverte d'un signe souvent négligéRapidly Progressive Glomerulonephritis: Classification, Pathogenetic Mechanisms, and TherapyTreatmentInvestigational therapy in rheumatoid arthritis: A critical reviewDrug Information Analysis ServiceCase 3, 1986Neurologic Complications of ChemotherapyNeurological Complications of Primary Brain Tumors 1 January 1986Volume 104, Issue 1Page: 58-59KeywordsEpileptic seizuresHyperglycemiaHypertensionRheumatology ePublished: 1 December 2008 Issue Published: 1 January 1986 PDF downloadLoading ...