tbuckley/cabot-search huggingface dataset:
Comparisons of Citations in Web of Science, Scopus, and Google Scholar for Articles Published in General Medical Journals
Authors: Abhaya V. Kulkarni
Journal: JAMA (2009)

<h3>Context</h3>Until recently, Web of Science was the only database available to track citation counts for published articles. Other databases are now available, but their relative performance has not been established.<h3>Objective</h3>To compare the citation count profiles of articles published in general medical journals among the citation databases of Web of Science, Scopus, and Google Scholar.<h3>Design</h3>Cohort study of 328 articles published in JAMA, Lancet, or the New England Journal of Medicine between October 1, 1999, and March 31, 2000. Total citation counts for each article up to June 2008 were retrieved from Web of Science, Scopus, and Google Scholar. Article characteristics were analyzed in linear regression models to determine interaction with the databases.<h3>Main Outcome Measures</h3>Number of citations received by an article since publication and article characteristics associated with citation in databases.<h3>Results</h3>Google Scholar and Scopus retrieved more citations per article with a median of 160 (interquartile range [IQR], 83 to 324) and 149 (IQR, 78 to 289), respectively, than Web of Science (median, 122; IQR, 66 to 241) (P &lt; .001 for both comparisons). Compared with Web of Science, Scopus retrieved more citations from non–English-language sources (median, 10.2% vs 4.1%) and reviews (30.8% vs 18.2%), and fewer citations from articles (57.2% vs 70.5%), editorials (2.1% vs 5.9%), and letters (0.8% vs 2.6%) (all P &lt; .001). On a log<sub>10</sub>-transformed scale, fewer citations were found in Google Scholar to articles with declared industry funding (nonstandardized regression coefficient, −0.09; 95% confidence interval [CI], −0.15 to −0.03), reporting a study of a drug or medical device (−0.05; 95% CI, −0.11 to 0.01), or with group authorship (−0.29; 95% CI, −0.35 to −0.23). In multivariable analysis, group authorship was the only characteristic that differed among the databases; Google Scholar had significantly fewer citations to group-authored articles (−0.30; 95% CI, −0.36 to −0.23) compared with Web of Science.<h3>Conclusion</h3>Web of Science, Scopus, and Google Scholar produced quantitatively and qualitatively different citation counts for articles published in 3 general medical journals.
LIPID SYNTHESIS (14C-ACETATE INCORPORATION) IN THE ISOLATED HUMAN SEBACEOUS GLAND, THE APPENDAGE-FREED EPIDERMIS, THE SEBOCYST (STEATOCYSTOMA) AND THE WEN (KERATINOUS CYST OF SKIN)
Authors: ROY SUMMERLY, SHEILA WOODBURY
Journal: British Journal of Dermatology (1972)

Journal Article LIPID SYNTHESIS (14C‐ACETATE INCORPORATION) IN THE ISOLATED HUMAN SEBACEOUS GLAND, THE APPENDAGE‐FREED EPIDERMIS, THE SEBOCYST (STEATOCYSTOMA) AND THE WEN (KERATINOUS CYST OF SKIN) Get access ROY SUMMERLY, ROY SUMMERLY MRC Unit on the Experimental Pathology of Skin, The Medical School, Birmingham 15, and Skin Department, North Staffordshire Hospital Centre, Stoke‐on‐Trent, Staffs Search for other works by this author on: Oxford Academic Google Scholar SHEILA WOODBURY SHEILA WOODBURY MRC Unit on the Experimental Pathology of Skin, The Medical School, Birmingham 15, and Skin Department, North Staffordshire Hospital Centre, Stoke‐on‐Trent, Staffs Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 86, Issue 6, 1 June 1972, Pages 614–619, https://doi.org/10.1111/j.1365-2133.1972.tb05077.x Published: 01 June 1972 Article history Accepted: 04 February 1972 Published: 01 June 1972
Disparate effects of colchicine on thyroxine-induced cardiac hypertrophy and adrenoceptor changes.
Authors: C Limas, C J Limas
Journal: Circulation Research (1991)

Short-term (5 days) administration of L-thyroxine (0.1 mg/kg i.p. daily) to adult Sprague-Dawley rats induces a modest degree of cardiac hypertrophy (22% increase in heart weight/body weight ratios) and directionally opposite changes in cardiac adrenoceptors (24% increase in beta-adrenoceptors and 20% decline in alpha 1-adrenoceptors). Pretreatment with colchicine did not affect the ability of L-thyroxine to induce cardiac hypertrophy but prevented its effects on both beta- and alpha 1-adrenoceptors. These results suggest a selective involvement of microtubules in the action of thyroid hormones on the expression of cardiac adrenoceptor genes.
Antibiotic prophylaxis in total hip replacement.
Authors: J P Pollard, S P Hughes, J E Scott, M J Evans, M K Benson
Journal: BMJ (1979)

A controlled prospective trial to compare the efficacy of the antibiotics cephaloridine and flucloxacillin in preventing infection after total hip replacement was conducted at three hospitals. The antibiotic regimens began before surgery, cephaloridine being continued for 12 hours and flucloxacillin for 14 days afterwards. Over an 18-month period 297 patients undergoing a total of 310 hip replacements were entered into the trial and randomly allocated to one of the regimens. The follow-up period ranged from one to two and a half years. All operations were performed in conventional operating theatres; at two of the hospitals these were also used by various other surgical disciplines. Four patients developed deep infection, two having received the cephaloridine and two the flucloxacillin regimen. The overall rate of deep infection was therefore 1.3%. Thus three doses of cephaloridine proved to be as effective as a two-week regimen of flucloxacillin. Giving a prophylactic systemic antibiotic reduced the incidence of infection to a level comparable with that obtained in ultra-clean-air operating enclosures.
Developmental regulation of a mucinlike glycoprotein selectively expressed on natural killer cells.
Authors: E Vivier, J M Sorrell, M Ackerly, M J Robertson, R A Rasmussen, H Levine, P Anderson
Journal: The Journal of Experimental Medicine (1993)

Natural killer (NK) cells are CD3:TCR-, CD16+, CD56+ large granular lymphocytes capable of recognizing and eliminating a variety of virus-infected, malignant, and antibody-coated target cells. Two functionally distinct populations of peripheral blood NK cells can be differentiated by their surface expression of an isoform of the neural cell adhesion molecule (CD56). CD56bright NK cells have the attributes of an undifferentiated cell, in that they proliferate in response to exogenous cytokines, but exert poor cytolytic activity. CD56dim NK cells have the attributes of a more differentiated cell, in that they proliferate poorly in response to exogenous cytokines, but are potent cytolytic effector cells. Here we describe the molecular characterization of a NK cell restricted epitope (PEN5) that is selectively expressed on the functionally differentiated CD56dim NK cells. PEN5+ NK cells proliferate poorly in response to interleukin 2 (IL-2), but are potent cytolytic effectors, whereas PEN5- NK cells proliferate in response to IL-2, but are poor cytolytic effectors. Biochemical and immunochemical analyses reveal the PEN5 epitope to be an unusual sulfated poly-N-lactosamine carbohydrate related to keratan sulfate glycosaminoglycans. Immunoprecipitates prepared using a monoclonal antibody reactive with PEN5 include two polydisperse membrane-bound glycoproteins, PEN5 alpha (120-170 kD) and PEN5 beta (210-245 kD). Enzymatic deglycosylation reduces the apparent molecular weight of both PEN5 isoforms by 80-90%, and classifies PEN5 beta as a mucinlike glycoprotein. The surface expression of the PEN5 epitope is downmodulated by stimuli that induce NK cell proliferation, and it is absent from leukemic NK cells of patients with granular lymphocyte proliferative disorder. Taken together, these results indicate that PEN5 is a developmentally regulated poly-N-lactosamine epitope associated with a mucin-type glycoprotein, whose expression is restricted to the population of nonproliferative NK cells fully committed to cytolytic effector function.
Adrenal suppression from high-dose inhaled fluticasone propionate in children with asthma: Fig. 1.—
Authors: D. Sim, A. Griffiths, D. Armstrong, C. Clarke, C. Rodda, N. Freezer
Journal: European Respiratory Journal (2003)

This cross-sectional study was designed to examine the prevalence of adrenocortical suppression in children with asthma treated with high-dose inhaled fluticasone propionate (FP). Children and adolescents (n=50) with asthma, treated with inhaled FP at a dose of > or = 1,000 mg a day for > or = 6 months, were enrolled. Early morning serum cortisol was performed. Subjects with a serum cortisol of < 400 nmol x L(-1) had a tetracosactrin stimulation test. Fifty subjects of mean age 13.1 yrs were treated with a mean dose of 924.7 microg x m(-2) x day(-1) FP for a mean duration of 2 yrs. Of the 50 subjects, 36 (72%) had serum cortisol levels of < 400 nmol x L(-1) and underwent tetracosactrin stimulation test. Of these, 6 (17%) demonstrated a less than two-fold increase in serum cortisol from baseline and peak cortisol level of < or = 550 nmol x L(-1) at 30 or 60 min poststimulation. There was a significant negative correlation between the dose of FP x m(-2) and stimulated peak cortisol level. Biochemical evidence of adrenocortical insufficiency was demonstrated in 12% of the subjects, indicating that high-dose fluticasone propionate use may be associated with dose-dependent adrenocortical suppression.
Turbulence facing the NHS risks having a negative impact on child protection, college says
Authors: H. Mooney
Journal: BMJ (2011)

The future of the NHS and the “huge turbulence” it faces risk having a worryingly negative impact on the protection of vulnerable children, the Royal College of Paediatrics and Child Health (RCPCH) has warned.

After publication of the Munro Review of Child Protection on 10 May the RCPCH said that NHS reforms could pose a major risk to child protection regardless of any proposals on the future of national child protection policy.

A spokeswoman for the RCPCH said that although the …
Smelling in color: a rainbow of possibilities.
Authors: C Potera
Journal: Environmental Health Perspectives (2001)

A sensor that detects dangerous odors better than the human nose may be able to "smell" dangerous air pollutants, soil contaminants, insecticides, food pathogens, biological warfare neurotoxins, and body odors associated with illness and disease. Called "smell-seeing" by its inventors, the method relies on color changes that occur in an array of vapor-sensitive dyes in response to exposure. By measuring the color change pattern, the researchers can identify a contaminant both qualitatively and quantitatively. This newest version of an artificial nose is simple, fast, and inexpensive. It can also eliminate the subjectivity associated with the human sense of smell and the perception of odors.
Differentiation capacity of hepatic stem/progenitor cells isolated from <scp>D</scp> -galactosamine-treated rat livers
Authors: Norihisa Ichinohe, Naoki Tanimizu, Hidekazu Ooe, Yukio Nakamura, Toru Mizuguchi, Junko Kon, Koichi Hirata, Toshihiro Mitaka
Journal: Hepatology (2012)

Oval cells and small hepatocytes (SHs) are known to be hepatic stem and progenitor cells. Although oval cells are believed to differentiate into mature hepatocytes (MHs) through SHs, the details of their differentiation process are not well understood. Furthermore, it is not certain whether the induced cells possess fully mature functions as MHs. In the present experiment, we used Thy1 and CD44 to isolate oval and progenitor cells, respectively, from D-galactosamine-treated rat livers. Epidermal growth factor, basic fibroblast growth factor, or hepatocyte growth factor could trigger the hepatocytic differentiation of sorted Thy1(+) cells to form epithelial cell colonies, and the combination of the factors stimulated the emergence and expansion of the colonies. Cells in the Thy1(+) -derived colonies grew more slowly than those in the CD44(+) -derived ones in vitro and in vivo and the degree of their hepatocytic differentiation increased with CD44 expression. Although the induced hepatocytes derived from Thy1(+) and CD44(+) cells showed similar morphology to MHs and formed organoids from the colonies similar to those from SHs, many hepatic differentiated functions of the induced hepatocytes were less well performed than those of mature SHs derived from the healthy liver. The gene expression of cytochrome P450 1A2, tryptophan 2,3-dioxygenase, and carbamoylphosphate synthetase I was lower in the induced hepatocytes than in mature SHs. In addition, the protein expression of CCAAT/enhancer-binding protein alpha and bile canalicular formation could not reach the levels of production of mature SHs.The results suggest that, although Thy1(+) and CD44(+) cells are able to differentiate into hepatocytes, the degree of maturation of the induced hepatocytes may not be equal to that of healthy resident hepatocytes. (HEPATOLOGY 2013).
Dancing on thin ice
Authors: Stan A. Kuczaj, Joana A. Ramos, Robin L. Paulos
Journal: Behavioral and Brain Sciences (2002)

The “new” paradigm proposed by Shanker &amp; King (S&amp;K) is neither new nor a significant advance in our understanding of communication. Although we agree that social interaction is important, ignoring the roles of mental processes and the significance of information exchange is theoretically dangerous. Moreover, the “communicative dance” is sequential. If one partner does not lead, how is the other to follow?
Improved efficiency of percutaneous adenoviral-mediated arterial gene transfer by pre-treatment with elastase
Authors: Luc Maillard, Marianne Ziol, Claude Le Feuvre, Ouafae Tahlil, Laurent J. Feldman, Didier Branellec, Michel Perricaudet, P.Gabriel Steg
Journal: Journal of the American College of Cardiology (1996)
Imatinib causes epigenetic alterations of PTEN gene via upregulation of DNA methyltransferases and polycomb group proteins
Authors: C Nishioka, T Ikezoe, J Yang, K Udaka, A Yokoyama
Journal: Blood Cancer Journal (2011)

We have recently reported the possible imatinib-resistant mechanism; long-term exposure of leukemia cells to imatinib downregulated levels of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) via hypermethylation of its promoter region (Leukemia 2010; 24: 1631). The present study explored the molecular mechanisms by which imatinib caused methylation on the promoter region of this tumor suppressor gene in leukemia cells. Real-time reverse transcription PCR found that long-term exposure of chronic eosinophilic leukemia EOL-1 cells expressing FIP1L1/platelet-derived growth factor receptor-α to imatinib induced expression of DNA methyltransferase 3A (DNMT3A) and histone-methyltransferase enhancer of zeste homolog 2 (EZH2), a family of polycomb group, thereby increasing methylation of the gene. Immunoprecipitation assay found the increased complex formation of DNMT3A and EZH2 proteins in these cells. Moreover, chromatin immunoprecipitation assay showed that amounts of both DNMT3A and EZH2 proteins bound around the promoter region of PTEN gene were increased in EOL-1 cells after exposure to imatinib. Furthermore, we found that levels of DNMT3A and EZH2 were strikingly increased in leukemia cells isolated from individuals with chronic myelogenous leukemia (n=1) and Philadelphia chromosome-positive acute lymphoblastic leukemia (n=2), who relapsed after treatment with imatinib compared with those isolated at their initial presentation. Taken together, imatinib could cause drug-resistance via recruitment of polycomb gene complex to the promoter region of the PTEN and downregulation of this gene's transcripts in leukemia patients.
Heat Shock Protein 90 Inhibitors Prolong Survival, Attenuate Inflammation, and Reduce Lung Injury in Murine Sepsis
Authors: Anuran Chatterjee, Christiana Dimitropoulou, Fotios Drakopanayiotakis, Galina Antonova, Connie Snead, Joseph Cannon, Richard C. Venema, John D. Catravas
Journal: American Journal of Respiratory and Critical Care Medicine (2007)

Rationale: Severe sepsis is the leading cause of death for patients in intensive care units. Patients with severe sepsis develop multiple organ failure, including acute lung injury (ALI), resulting from a deregulated inflammatory response. Inhibitors of the ubiquitous chaperone, heat shock protein 90 (Hsp90), block the activity of certain proinflammatory mediators in vitro. We hypothesized that Hsp90 inhibitors may ameliorate the inflammation and ALI associated with severe sepsis.Objectives: To test the hypothesis that Hsp90 inhibitors prolong survival, attenuate inflammation, and reduce lung injury in a murine model of sepsis.Methods: Male C57BL/6 mice received either one of two Hsp90 inhibitors, radicicol or 17-allylaminodemethoxygeldanamycin (17-AAG), 24, 12, 6, and 0 hours before receiving a lethal dose of endotoxin (6.75 × 104 endotoxin units/g body weight). Outcomes included survival and parameters of systemic inflammation (plasma neutrophil, cytokine, chemokine, and nitrite/nitrate levels), pulmonary inflammation (lung nuclear factor-κB and myeloperoxidase activities, inducible nitric oxide synthase expression, inducible nitric oxide synthase–Hsp90 complex formation, and leukocyte infiltration), and lung injury (pulmonary capillary leak and lung function).Measurements and Main Results: Mice pretreated with vehicle and receiving endotoxin exhibited 100% 24-hour lethality, a dramatic increase in all parameters of systemic and pulmonary inflammation, increased capillary leak, and reduced lung function. Compared with them, mice receiving either radicicol or 17-AAG before endotoxin exhibited prolonged survival, reduced or abolished increases in systemic and pulmonary inflammatory parameters, attenuated capillary leak, and restored, normal lung function.Conclusions: Hsp90 inhibitors may offer a new pharmacological tool in the management of severe sepsis and severe sepsis–induced ALI.
Transcriptome Analysis in Peripheral Blood of Humans Exposed to Environmental Carcinogens: A Promising New Biomarker in Environmental Health Studies
Authors: Danitsja M. van Leeuwen, Ralph W.H. Gottschalk, Greet Schoeters, Nicolas A. van Larebeke, Vera Nelen, Willy F. Baeyens, Jos C.S. Kleinjans, Joost H.M. van Delft
Journal: Environmental Health Perspectives (2008)

Human carcinogenesis is known to be initiated and/or promoted by exposure to chemicals that occur in the environment. Molecular cancer epidemiology is used to identify human environmental cancer risks by applying a range of effect biomarkers, which tend to be nonspecific and do not generate insights into underlying modes of action. Toxicogenomic technologies may improve on this by providing the opportunity to identify molecular biomarkers consisting of altered gene expression profiles.The aim of the present study was to monitor the expression of selected genes in a random sample of adults in Flanders selected from specific regions with (presumably) different environmental burdens. Furthermore, associations of gene expression with blood and urinary measures of biomarkers of exposure, early phenotypic effects, and tumor markers were investigated.Individual gene expression of cytochrome p450 1B1, activating transcription factor 4, mitogen-activated protein kinase 14, superoxide dismutase 2 (Mn), chemokine (C-X-C motif) lig-and 1 (melanoma growth stimulating activity, alpha), diacylglycerol O-acyltransferase homolog 2 (mouse), tigger transposable element derived 3, and PTEN-induced putative kinase1 were measured by means of quantitative polymerase chain reaction in peripheral blood cells of 398 individuals. After correction for the confounding effect of tobacco smoking, inhabitants of the Olen region showed the highest differences in gene expression levels compared with inhabitants from the Gent and fruit cultivation regions. Importantly, we observed multiple significant correlations of particular gene expressions with blood and urinary measures of various environmental carcinogens.Considering the observed significant differences between gene expression levels in inhabitants of various regions in Flanders and the associations of gene expression with blood or urinary measures of environmental carcinogens, we conclude that gene expression profiling appears promising as a tool for biological monitoring in relation to environmental exposures in humans.
Eczema vaccinatum treated with N-methylisatin β-thiosemicarbazone.
Authors: J. F. Webb, R. Marks, T. A. G. Reed
Journal: British Journal of Dermatology (1965)

Journal Article Eczema vaccinatum treated with N‐methylisatin β‐thiosemicarbazone. Get access J. F. col. Webb, J. F. col. Webb Munster, B.A.O.R Search for other works by this author on: Oxford Academic Google Scholar R. Marks, R. Marks Munster, B.A.O.R Search for other works by this author on: Oxford Academic Google Scholar T. A. G. col. Reed T. A. G. col. Reed Munster, B.A.O.R Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 77, Issue 11, 1 November 1965, Pages 596–597, https://doi.org/10.1111/j.1365-2133.1965.tb14584.x Published: 01 November 1965
Spatial immobilization of bone morphogenetic protein-4 in a collagen-PLGA hybrid scaffold for enhanced osteoinductivity
Authors: Hongxu Lu, Naoki Kawazoe, Takashi Kitajima, Yuka Myoken, Masahiro Tomita, Akihiro Umezawa, Guoping Chen, Yoshihiro Ito
Journal: Biomaterials (2012)
THE EXCRETION OF INORGANIC SULPHATES
Authors: J. M. Hayman, Sara M. Johnston
Journal: Journal of Clinical Investigation (1932)

Among many estimations of blood concentration and rate of excretion of various substances in the urine, relatively few have been concerned with inorganic sulphates.These, regarded as waste products highly con- centrated in the urine, are usually classed with creatinine and many foreign bodies as "no-threshold" substances.Cushny (1926), however, cautioned that "sulphates cannot yet be assigned a definite position as it is uncertain whether they should be placed along with phosphates (low threshold) or among the no-threshold bodies."After injection of sulphate and creatinine in rabbits, Mayrs (1922) did not find them concentrated by the kidney to exactly the same degree, although the ratios were so close he regarded it as strong evidence that they were excreted by the same process.The slight differences in the concentration ratios he attributed to reabsorption from a glomerular filtrate of small amounts of even these substances during its passage down the tubule.Poulsson (1930a) found the concentration in milligrams per cent of inorganic sulphates in human urine proportional to the degree of concentration of the urine estimated by urine and blood creatinine, con- cluding that the two substances were eliminated by the same process and concentrated to the same degree; i.e., that sulphates had no threshold, or that little if any diffused back through tubule cells.Ambard (1931), likewise, grouped sulphates with the no-threshold bodies.White (1923) on the other hand did not find any regular correspond- ence in concentration ratios of phosphate, sulphate and sugar in phlorid- zinized dogs and this led him to exclude these from " no-threshold " bodies and to fall back on tubular secretion of sulphate.Marshall and Crane (1922) found the excretion of sulphate increased by section of the splanchnic nerve, while that of creatinine was little affected.They suggested that possibly some sulphate may be reabsorbed from the glomerular filtrate, or that additional sulphate may be secreted by the tubule cells.The studies here described were undertaken with the thought of checking the estimated volume of glomerular filtrate according to Reh- berg's (1926) creatinine technique by simultaneous determinations of