tbuckley/cabot-search huggingface dataset:
Planned Parenthood v Casey
Authors: Rod M. Duraski
Journal: JAMA (1993)

<h3>To the Editor.</h3> —I would like to comment on the article by Benshoof.<sup>1</sup>While it is a well-written and interesting article, it is replete with misleading statements and is not as neutral or unbiased as she would have us believe. Her article is staunchly proabortion, and she never acknowledges or demonstrates concern for the view that the humanity of the fetus is a central concern to those of us who oppose abortion on demand. Like most proabortion apologists, she emphasizes the right to privacy as the central issue, thereby obscuring the issue of the existence of human life in the fetus. It should be said that even Justice Blackmun, in his majority opinion of<i>Roe v Wade</i>, stated that the right to privacy is not absolute and concludes that "the right of personal privacy includes the abortion decision, but that this right is not unqualified and must be considered
Ultrasound energy improves myocardial perfusion in the presence of coronary occlusion
Authors: Robert J. Siegel, Valentina N. Suchkova, Takashi Miyamoto, Huai Luo, Raymond B. Baggs, Yoram Neuman, Michael Horzewski, Veijo Suorsa, Sergio Kobal, Todd Thompson, Debra Echt, Charles W. Francis
Journal: Journal of the American College of Cardiology (2004)
Surviving a viva: a guide for candidates
Authors: L. Cascarini, D G Lowe
Journal: Journal of the Royal Society of Medicine (2004)

To pass a viva a candidate must not only possess a thorough understanding of the subject but must also be able to convey this to the examiners. Vivas are different from other exams: you cannot deal first with the questions you know best and come back later to the ones you are not so sure about; and you cannot cross out previous answers and rewrite them. In assembling the knowledge base it may be helpful to remember facts in a way that makes them easily retrieved and communicated in a viva. An intelligent, structured, cogent answer wins the points.
Review of Exercise Intervention Studies in Cancer Patients
Authors: Daniel A. Galvão, Robert U. Newton
Journal: Journal of Clinical Oncology (2005)

Purpose To present an overview of exercise interventions in cancer patients during and after treatment and evaluate dose-training response considering type, frequency, volume, and intensity of training along with expected physiological outcomes. Methods The review is divided into studies that incorporated cardiovascular training, combination of cardiovascular, resistance, and flexibility training, and resistance training alone during and after cancer management. Criteria for inclusion were based on studies sourced from electronic and nonelectronic databases and that incorporated preintervention and postintervention assessment with statistical analysis of data. Results Twenty-six published studies were summarized. The majority of the studies demonstrate physiological and psychological benefits. However, most of these studies suffer limitations because they are not randomized controlled trials and/or use small sample sizes. Predominantly, studies have been conducted with breast cancer patients using cardiovascular training rather than resistance exercise as the exercise modality. Recent evidence supports use of resistance exercise or “anabolic exercise” during cancer management as an exercise mode to counteract side effects of the disease and treatment. Conclusion Evidence underlines the preliminary positive physiological and psychological benefits from exercise when undertaken during or after traditional cancer treatment. As such, other cancer groups, in addition to those with breast cancer, should also be included in clinical trials to address more specifically dose-response training for this population. Contemporary resistance training designs that provide strong anabolic effects for muscle and bone may have an impact on counteracting some of the side effects of cancer management assisting patients to improve physical function and quality of life.
THE ARSENICAL TREATMENT OF SYPHILIS
Authors: JOHN B. MURPHY
Journal: JAMA (1910)

Much attention has recently been paid to the arsenic treatment of syphilis and particularly to the Ehrlich-Hata preparation known as "606", i. e., the dioxydiamidoarsenobenzol dihydrochlorid, a single injection of a proper dose of which is reported to be destructive of the<i>Spirochœta pallida</i>. The recently recorded cases show a striking uniformity in the immediate curative effects in all of the spirilloses, or diseases of spirochetic origin. It is believed that this arsenical preparation is as destructive of the spirochetes as quinin is of the plasmodia of malaria. The spirochetes disappear entirely from the local lesion and from the blood in from four to ten hours after the injection of the remedy and the disease appears to be entirely arrested in twenty-four hours. These seem astonishing statements but they are verified by a number of able observers as Ehrlich, Hata, Wechselmann, Alt of Uchtspring, Schreiber of Magdeburg, Iversen of Russia
HLA and Disease Susceptibility: A Primer
Authors: Leon E. Rosenberg, Kenneth K. Kidd
Journal: New England Journal of Medicine (1977)

Several hundred papers, each reporting an increased frequency of one or more HLA antigens among patients with a particular human disease, have appeared in the medical literature in the last few years. This literary deluge, to which the New England Journal of Medicine has been a notable contributor, has already been reviewed several times.1 2 3 4 5 Although some "HLAfficionados" applaud each new association with disease as evidence for etiologic factors involving autoimmune, or at least altered, immune function under specific gene control, interpretations of these associations are not necessarily so simple, and the data are often confusing and contradictory. For these reasons . . .
The independent medical practitioner
Authors: R. Colman
Journal: BMJ (1997)

A general medical training is a most flexible friend and valuable asset. Doctors trained as general practitioners have the potential to develop an independent medical career offering differing degrees of variety and flexibility. I put forward the example of my own career, not as a model of perfection, but to illustrate some of the opportunities, requirements, and difficulties faced by the independently minded doctor.

First the downside. There is financial insecurity. Having a partner prepared to live with that-and forego any preconceived expectations of life as the doctor's other half-may reduce problems arising at future times of doubt and uncertainty. Continuing education, holiday pay, and pension contributions must be paid from your own pocket. NHS principals have an easier financial ride in these areas, and also have more status and respect-the lack of which is perhaps most keenly felt by my mother. Independent doctors must also suffer the connotation, held in the minds of more conventional colleagues, that they are somehow irresponsible, weak, or failed-sentiments which are often surprisingly reversed in a quiet moment by the admiring GP who privately expresses the wish that he or she had done what I have. Working relations with colleagues can be strained: they may resent your presence. You can be perceived as a threat to their ego, their medical skills, and can seem to offer a test of their patients' loyalty.

During my last year of vocational training in general practice, instead of looking for a practice as my colleagues were doing, my wife and I had been looking for an environment and potential life style. We found it in North Yorkshire: we took on a repair lease of a National Trust farm house in Bransdale, a dale owned by the Trust in the middle of the North Yorkshire Moors National Park. The …
Suppressive effects of cyclosporin a in murine schistosomiasis
Authors: Michael A. Dunn
Journal: Hepatology (1989)

Cyclosporin A (CsA), administered subcutaneously as 5 daily injections of 50 mg·kg −1 , reduced the numbers of Schistosoma mansoni perfused from MF1 mice at 7 weeks post-infection. The timing of drug administration revealed that the antischistosomal effects were greater when CsA treatment coincided with or was within a few days of infection with a parasite. CsA exerted a clear prophylactic effect, which decreased with time and was virtually abolished by 4 months pre-infection. Adult worms treated in vivo were partially susceptible to CsA. In addition to its antiparasite action, CsA reduced hepatosplenomegaly due to schistosomiasis and diminished the granulomatous inflammatory response of mice to parasite eggs in the liver. The mode of action of CsA is not understood but evidence is presented that supports the proposition that the anti-parasite effects are perhaps host-mediated.
Efficacy, Safety, and Immunogenicity of an Enterovirus 71 Vaccine in China
Authors: Fengcai Zhu, Wenbo Xu, Jielai Xia, Zhenglun Liang, Yan Liu, Xuefeng Zhang, Xiaojuan Tan, Ling Wang, Qunying Mao, Junyu Wu, Yuemei Hu, Tianjiao Ji, Lifei Song, Qi Liang, Baomin Zhang, Qiang Gao, Jingxin Li, Shenyu Wang, Yuansheng Hu, Shanru Gu, Jianhua Zhang, Genhong Yao, Jianxiang Gu, Xushan Wang, Yuchun Zhou, Changbiao Chen, Minglei Zhang, Minquan Cao, Junzhi Wang, Hua Wang, Nan Wang
Journal: New England Journal of Medicine (2014)

Enterovirus 71 (EV71) is one of the major causative agents of outbreaks of hand, foot, and mouth disease or herpangina worldwide. This phase 3 trial was designed to evaluate the efficacy, safety, and immunogenicity of an EV71 vaccine.We conducted a randomized, double-blind, placebo-controlled, multicenter trial in which 10,007 healthy infants and young children (6 to 35 months of age) were randomly assigned in a 1:1 ratio to receive two intramuscular doses of either EV71 vaccine or placebo, 28 days apart. The surveillance period was 12 months. The primary end point was the occurrence of EV71-associated hand, foot, and mouth disease or herpangina.During the 12-month surveillance period, EV71-associated disease was identified in 0.3% of vaccine recipients (13 of 5041 children) and 2.1% of placebo recipients (106 of 5028 children) in the intention-to-treat cohort. The vaccine efficacy against EV71-associated hand, foot, and mouth disease or herpangina was 94.8% (95% confidence interval [CI], 87.2 to 97.9; P<0.001) in this cohort. Vaccine efficacies against EV71-associated hospitalization (0 cases vs. 24 cases) and hand, foot, and mouth disease with neurologic complications (0 cases vs. 8 cases) were both 100% (95% CI, 83.7 to 100 and 42.6 to 100, respectively). Serious adverse events occurred in 111 of 5044 children in the vaccine group (2.2%) and 131 of 5033 children in the placebo group (2.6%). In the immunogenicity subgroup (1291 children), an anti-EV71 immune response was elicited by the two-dose vaccine series in 98.8% of participants at day 56. An anti-EV71 neutralizing antibody titer of 1:16 was associated with protection against EV71-associated hand, foot, and mouth disease or herpangina.The EV71 vaccine provided protection against EV71-associated hand, foot, and mouth disease or herpangina in infants and young children. (Funded by Sinovac Biotech; ClinicalTrials.gov number, NCT01507857.).
Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes. HOE 901/3002 Study Group.
Authors: H Yki-Järvinen, A Dressler, M Ziemen
Journal: Diabetes Care (2000)

OBJECTIVE: Available basal insulin formulations do not provide a constant and reliable 24-h insulin supply. We compared the efficacy and safety of glargine (a long-acting insulin analog) and NPH insulins in insulin-naive type 2 diabetic patients treated with oral antidiabetic agents. RESEARCH DESIGN AND METHODS: There were 426 type 2 diabetic patients (age 59 +/- 9 years, BMI 28.9 +/- 4.3 kg/m2, mean +/- SD) with poor glycemic control on oral antidiabetic agents randomized to treatment for 1 year with bedtime insulin glargine or bedtime NPH insulin. Oral agents were continued unchanged. The fasting blood glucose (FBG) target was 6.7 mmol/l (120 mg/dl). RESULTS: Average glycemic control improved similarly with both insulins (HbA(1c), [reference range &amp;lt;6.5%] 8.3 +/- 0.1 vs. 8.2 +/- 0.1% at 1 year, glargine vs. NPH, mean +/- SEM, P &amp;lt; 0.001 vs. baseline for both). However, there was less nocturnal hypoglycemia (9.9 vs. 24.0% of all patients, glargine vs. NPH, P &amp;lt; 0.001) and lower post-dinner glucose concentrations (9.9 +/- 0.2 vs. 10.7 +/- 0.3 mmol/l, P &amp;lt; 0.02) with insulin glargine than with NPH. Insulin doses and weight gain were comparable. In patients reaching target FBG, HbA(1c) averaged 7.7 and 7.6% in the glargine and NPH groups at 1 year. CONCLUSIONS: Use of insulin glargine compared with NPH is associated with less nocturnal hypoglycemia and lower post-dinner glucose levels. These data are consistent with peakless and longer duration of action of insulin glargine compared with NPH. Achievement of acceptable average glucose control requires titration of the insulin dose to an FBG target &amp;lt; or =6.7 mmol/l. These data support use of insulin glargine instead of NPH in insulin combination regimens in type 2 diabetes.
Inflammation in cystic fibrosis airways: relationship to increased bacterial adherence
Authors: P. Scheid, L. Kempster, U. Griesenbach, J.C. Davies, A. Dewar, P.P. Weber, W.H. Colledge, M.J. Evans, D.M. Geddes, E.W.F.W. Alton
Journal: European Respiratory Journal (2001)

It is unclear whether inflammation in the cystic fibrosis (CF) lung relates predominantly to bacterial infection, or occurs as a direct consequence of mutant cystic fibrosis transmembrane conductance regulator (CFTR) protein. Interleukin (IL)-8 secretion from CF and non-CF cell lines, and from CF and non-CF human primary nasal epithelial cells incubated with or without Pseudomonas aeruginosa , was measured. Activation of nuclear factor-κB (NF-κB) in unstimulated CF and non-CF nasal epithelial cells, cell lines and murine tissues was measured by gel-shift assays. No significant difference in basal IL-8 production or NF-κB activation was observed between CF and non-CF primary nasal cells. However, CF cells exhibited a significantly (p&lt;0.01) increased IL-8 secretion following P. aeruginosa stimulation. Equalization of the increased P. aeruginosa adherence observed in CF cells, to non-CF levels, resulted in comparable IL-8 secretion. Further, IL-8 production did not differ with mutations which result in either correctly localized CFTR, or in partial/total mislocalization of this protein. Similar levels of NF-κB activation were observed in a number of organs of wild-type and CF mice. Finally, IL-8 secretion and NF-κB activity were not consistently increased in CF cell lines. Cos-7 cell transfection with plasmids expressing ΔF508 or G551D mutant CFTR protein resulted in increased activation of a p50-containing NF-κB complex, but IL-8 secretion was similar to wild-type cells. The authors conclude that the stimulus produced by Pseudomonas aeruginosa is the predominant inflammatory trigger in their models.
THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES
Authors: Zanvil A. Cohn, Belinda Benson
Journal: The Journal of Experimental Medicine (1965)

The in vitro differentiation of homogeneous populations of monocyte-like cells from the unstimulated mouse peritoneal cavity is described. Under the conditions employed, a progressive increase in cell size occurs without significant cell division. This process is characterized morphologically by the accumulation of phase-dense and neutral red-positive granules, mitochondria, and lipid droplets. The phase-dense granules react strongly for acid phosphatase. Biochemical determinations indicate marked increases in the total content and specific activity of acid phosphatase, cathepsin, and ß-glucuronidase. The production of acid phosphatase is more rapid and extensive than that of the other two hydrolases. From these data it appears that the conversion of a monocyte-like cell to a mature macrophage is accompanied by the formation of increased numbers of lysosome-like cytoplasmic organelles. Mouse peritoneal phagocytes stimulated in vivo with a bacterial lipopolysaccharide undergo a similar series of morphological and biochemical events.
Over-expression of Follistatin-like 3 attenuates fat accumulation and improves insulin sensitivity in mice
Authors: Claus Brandt, Rasmus Hvass Hansen, Jakob Bondo Hansen, Caroline Holkmann Olsen, Pia Galle, Thomas Mandrup-Poulsen, Julie Gehl, Bente Klarlund Pedersen, Pernille Hojman
Journal: Metabolism (2014)
Influence of thrombophilia on risk of recurrent venous thromboembolism while on warfarin: results from a randomized trial
Authors: Clive Kearon, Jim A. Julian, Michael J. Kovacs, David R. Anderson, Philip Wells, Betsy MacKinnon, Jeffrey I. Weitz, Mark A. Crowther, Sean Dolan, Alexander G. Turpie, William Geerts, Susan Solymoss, Paul van Nguyen, Christine Demers, Susan R. Kahn, Jeannine Kassis, Marc Rodger, Julie Hambleton, Michael Gent, Jeffrey S. Ginsberg
Journal: Blood (2008)
I don't like Mondays (after bank holidays)
Authors: Peter Kirkbride
Journal: BMJ (2004)

Although everyone, to some extent, lives their life according to the days of the week, this phenomenon is perhaps most noticeable in the NHS. If it's Tuesday, it must be theatre/clinic/wardround. This is never so clear as in spring, when each hospital in the United Kingdom has to cancel a disproportionate number of activities scheduled for a Monday because of three bank holidays (Easter, May Day, Whitsun) occurring within a couple of months.

Anyone who has come into contact with the NHS Modernisation Agency recently will know that it has identified one of the biggest problems leading to prolonged waiting times as a mismatch of capacity and demand. …
Phorbol diester-induced macrophage differentiation of leukemic blasts from patients with human myelogenous leukemia.
Authors: H P Koeffler, M Bar-Eli, M Territo
Journal: Journal of Clinical Investigation (1980)

Phorbol esters, including 12-O-tetradecanoylphorbol 13-acetate (TPA), induce terminal macrophagelike differentiation of cells from human acute myelogenous leukemia lines. We report that myelogenous leukemia cells obtained from patients undergo macrophagelike differentiation after exposure to TPA. The myeloid leukemic cell cultured with TPA became adherent to charged surfaces with long filamentous pseudopodia; developed positive staining for alpha-napthyl acetate esterase, increased lysozyme secretion, reduced nitroblue tetrazolium, and acquired the ability to phagocytose candida. Cells from patients with lymphocytic leukemia did not become macrophagelike when cultured with TPA.
I. The General Setting
Authors: Waltraud Bolz, Adolf-Ernst Meyer
Journal: Psychotherapy and Psychosomatics (1981)

Research Articles| February 16 2010 I. The General Setting Subject Area: Psychiatry and Psychology Waltraud Bolz; Waltraud Bolz Search for other works by this author on: This Site PubMed Google Scholar Adolf-Ernst Meyer Adolf-Ernst Meyer Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1981) 35 (2-3): 85–95. https://doi.org/10.1159/000287484 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Waltraud Bolz, Adolf-Ernst Meyer; I. The General Setting. Psychother Psychosom 31 December 1981; 35 (2-3): 85–95. https://doi.org/10.1159/000287484 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1981Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Chronic Cadmium Exposure <i>in Vitro</i> Causes Acquisition of Multiple Tumor Cell Characteristics in Human Pancreatic Epithelial Cells
Authors: Wei Qu, Erik J. Tokar, Andrew J. Kim, Matthew W. Bell, Michael P. Waalkes
Journal: Environmental Health Perspectives (2012)

Cancer may be a stem cell (SC)-based disease involving formation of cancer SCs (CSCs) potentially arising from transformation of normal SCs. Cadmium has been linked to human pancreatic cancer.We studied cadmium exposure of human pancreatic ductal epithelial (HPDE) cells and whether SCs may be targeted in this process.We chronically exposed HPDE cells to low level cadmium (1 μM) for ≤ 29 weeks. Nonadherent spheroid formation was used to indicate CSC-like cell production, and we assessed tumor cell characteristics in such spheres. Assessed tumor cell characteristics including secretion of matrix metalloproteinase-9 (MMP-9), invasion, and colony formation were fortified by evaluating expression of relevant genes by real-time reverse transcription polymerase chain reaction and by Western blot.Increased MMP-9 secretion and overexpression of the pancreatic cancer marker S100P occurred in chronic (29 weeks of exposure) cadmium-exposed (CCE) cells. CCE cells also showed markedly higher colony formation and invasion, typical of cancer cells. Floating "spheres" of viable cells, known to contain an abundance of normal SCs or CSCs, form in vitro with many cell types. CCE cells produced 3-fold more spheres than control cells and were more invasive, secreted more MMP-9, and overexpressed markers for pancreatic SCs/CSCs (i.e., CXCR4, OCT4, CD44) and S100P, a marker for pancreatic cancer. CCE-derived spheres rapidly produced aggressive, highly branched, and poorly differentiated glandular-like structures in Matrigel.Chronic cadmium exposure produced multiple tumor cell characteristics in HPDE cells and CCE cell-derived spheres. These data support the plausibility of cadmium as a human pancreatic carcinogen.