tbuckley/cabot-search huggingface dataset:
Circulating platelet/polymorphonuclear leukocyte mixed-cell aggregates in patients with mechanical heart valve replacement
Authors: Norma Maugeri, Maria Teresa Santarelli, Maria Angela Lazzari
Journal: American Journal of Hematology (2000)

There is convincing evidence that cell adhesion plays an important role in cardiovascular pathology and is frequently associated to "in vivo" cellular activation. This study involves patients with mechanical heart valve replacement (MHVR patients) who have increased platelet polymorphonuclear leukocyte (PMN) reactivity. Dual-color cytometry was used to determine the expression of adhesive molecules on cellular surfaces, platelet, and PMN-bound fibrinogen as well as the presence of circulating platelet/PMN mixed-cell aggregates (MCA) in 55 MHVR patients, 49 control patients under oral anticoagulant therapy, and 22 healthy volunteers. The results demonstrated that (a) PMN from MHVR patients showed an increased PMN-bound fibrinogen (mean ± SEM: 1,420 ± 169 anti-fibrinogen fluorescence intensity, P= 0.0012), when compared to controls (mean ± SEM: 747 ± 32 anti-fibrinogen fluorescence intensity) and healthy volunteers (mean ± SEM: 692 ± 25 anti-fibrinogen fluorescence intensity; (b) platelet activation in MHVR patients was evidenced by the higher expression of CD62P (mean ± SEM: 128 ± 19 anti-CD62P fluorescence intensity, P = 0.003) compared to controls (mean ± SEM: 65 ± 15 and 50 ± 10 anti CD62P fluorescence intensity) and by increased levels of platelet-bound fibrinogen (mean ± SEM: 625 ± 20 anti-fibrinogen fluorescence intensity, P = 0.0043 versus 496 ± 45 and 480 ± 30 for control patients and for healthy volunteers, respectively); and (c) the proportion of MCA in MHVR patients (15 ± 2%) was significantly higher (P = 0.009) compared to controls (7 + 1%) and healthy volunteers (6 ± 2%). The results indicate that the presence of stable circulating MCA represents another marker of "in vivo" PMN activation in MHVR patients. Am. J. Hematol. 65:93–98, 2000. © 2000 Wiley-Liss, Inc.
Assessment of the DQB1-DQA1 Complete Genotype Allows Best Prediction for IDDM
Authors: Giovanna Tosi, Alberto Facchin, Leonardo Pinelli, Roberto S Accolla
Journal: Diabetes Care (1994)

OBJECTIVE To analyze the HLA-DQ (human leukocyte antigen) genetic association with insulin-dependent diabetes mellitus (IDDM) patients of the Northeast Italian population. RESEARCH DESIGN AND METHODS Fifty-one IDDM patients and 52 healthy control subjects were molecularly typed for DQB1 and DQA1 loci by using allele-specific oligonucleotide probes and polymerase chain reaction amplified genomie DNA. DNA enzyme immunoassay was used to assess allele specificities. RESULTS IDDM status strongly correlated with DQB1 alleles carrying a non-aspartic acid (non-Asp) residue in position 57 of DQα-chain and DQA1 alleles with an arginine (Arg) residue in position 52 of DQa-chain. Individuals with two DQB1 (non-Asp) alíeles and two DQAl(Arg) alleles had the highest relative risk for disease: they constituted ∼40% of IDDM patients compared with 0% of control subjects. Heterozy-gosis at either residue 57 of DQB1 or residue 52 of DQA1 was sufficient to abrogate statistical significance for disease association, although 47% of IDDM patients were included in these two groups compared with 21% of normal control subjects. On the other hand, the presence of two DQB1 alleles with Asp in position 57 was sufficient to confer resistance to disease irrespective of the DQA1 genotype. CONCLUSIONS The results demonstrate that the complete HLA-DQ genotype, more than a single DQB1 or DQA1 locus, should be determined to estimate the highest risk for disease. Screening a population for preventive purposes and/or early signs of IDDM should then take advantage of this result, and “susceptible homozygous” individuals should be followed very closely and considered the first group of choice for possible new therapeutic trials.
PAROTID GLANDS IN DIABETES
Authors: DAVID W. FRASER
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 July 1969PAROTID GLANDS IN DIABETESDAVID W. FRASERDAVID W. FRASERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-1-212_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: I was most interested in the article by Davidson, Leibel, and Berris (1) entitled "Asymptomatic Parotid Gland Enlargement in Diabetes Mellitus" (Ann. Intern. Med. 70: 31, 1969). Their finding of parotid enlargement in patients with subclinical diabetes deserves emphasis.I was surprised, however, by the authors' statement that they could find no well-documented reports of biopsies of enlarged parotids in diabetes. In his impressive book on salivary gland disorders Rauch (2) presents the case of a 58-year-old male diabetic with bilateral parotid gland enlargement. A biopsy of this man's left parotid showed enlargement of the acinar cells...References1. DAVIDSONLEIBELBERRIS DBSB: Asymptomatic parotid gland enlargement in diabetes mellitus. Ann. Intern. Med. 70: 31, 1969. LinkGoogle Scholar2. RAUCH S: Die Speicheldrüsen des Menschen. Anatomie, Physiologie und klinische Pathologie, Georg Thieme Verlag, Stuttgart, 1959, p. 320. Google Scholar3. DU PLESSIS DJ: Parotid enlargement in malnutrition. S. Afr. Med. J. 30: 700, 1956. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Harvard Medical School Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1969Volume 71, Issue 1Page: 212-213KeywordsBiopsyCellsDiabetes mellitusParotid glandsSalivary glands Issue Published: 1 July 1969 PDF downloadLoading ...
Improving Prevention of Mother-to-Child Transmission of HIV Care and Related Services in Eastern Rwanda
Authors: Younsook Lim, Jim Yong Kim, Michael Rich, Sara Stulac, Jean Bosco Niyonzima, Mary C. Smith Fawzi, Rose Gahire, Martha Mukaminega, Marya Getchell, Curtis W. Peterson, Paul E. Farmer, Agnès Binagwaho
Journal: PLoS Medicine (2010)

The Health in Action section is a forum for individuals or organizations to highlight their innovative approaches to a particular health problem.
Pediatrics II. Miscellanea
Authors: X. Pastor, J. Jaurégulzar, A. Palomeque, C. Sierra, M. L. Sonnet, D. Floret, D. Perrot, D. Stamm, I. A. Murdoch, A. Mitchell, S. Parsons, S. A. Qureshi, R. Brangenberg, M. Bodensohn, U. Bürger, J. H. Reeves, W. W. Butt, A. -L. Kuusela, T. Ruuska, R. Karikoski-Leo, V. Lautamatti
Journal: Intensive Care Medicine (1992)
Retroperitoneal Effusions in Renal Regions
Authors: G. A. G. Mitchell
Journal: BMJ (1939)

of lymphosarcoma Hynes (1939) found the marrow normal in six, but there were 61 per cent.lymphatic cells in the remaining patient's marrow.In a series of over 100 patients I= have found lymphocytosis of the marrow in only two conditions besides lymphatic leukaemia; these are glandular fever and aplastic-type anaemias.In glandular fever the lymphoid cells in the marrow are increased-in one patient there were 55 per cent.-butif these are discounted all the other normal varieties of cells are present in their normal proportions.In aplastictype anaemia there may be a marrow lymphocytosis of 70 per cent.or more; but this is only relative, and the raised percentage of lymphocytes is due to the decrease of all the other marrow cells.Patients similar to those described here have been reported by Nordenson (1935), Schulten (1937), and Storti (1937).There seems, therefore, to be little doubt that the finding of lymphocytosis of the bone marrow is strong evidence that the patient has lymphatic leukaemia.Clinically the patients fall roughly into two groups: an acute group (Cases I and II) with a fairly rapid course to a fatal termination, and a chronic group (Cases III, IV, and V) whose clinical and haematological condition remains stationary for long periods.In the acute group radiotherapy seems to be of little value; in the chronic group radiotherapy can be advantageously withheld for a long time, and, as in the somewhat similar myeloid leukaemia patients (Israels, 1939b), treatment can be restricted to normal anti-anaemic measures so long as no severe anaemia occurs. SummaryIn patients with lymphatic leukaemia the sternal marrow shows a lymphocytosis even when the clinical signs and the peripheral blood pictures are atypical.This lymphocytosis is strong evidence for the diagnosis of lymphatic leukaemia, since it is not usually found in other conditions.The clinical course and the treatment of these atypical cases
Reduced Oral Etoposide Bioavailability in Patients With Advanced Cancer of the Head and Neck
Authors: B. Desoize, V. Woirin, M. Legros, P. Coninx
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Reduced Oral Etoposide Bioavailability in Patients With Advanced Cancer of the Head and Neck Get access Bernard Desoize, Bernard Desoize * Laboraloire de Phar-macologie Institut Jean-Godinot, ReimsFrance *Correspondence to : Bernard Desoize, Ph. D., Groupe d’étude des Interactions des Substances Anticancéreuses, Institut Jean-Godinot, Labora-toire de Pharmacologie et de Pharmacocinétique, 1 rue du Général Koenig, BP 171, 51056 Reims Cédex, France. Search for other works by this author on: Oxford Academic PubMed Google Scholar Véronique Woirin, Véronique Woirin Laboraloire de Phar-macologie Institut Jean-Godinot, ReimsFrance Search for other works by this author on: Oxford Academic PubMed Google Scholar Michel Legros, Michel Legros Service d'Otorhinolarynologie, Hôpital R. DebréReims, France.Joint Committee of Head and Neck CancerReims, France. Search for other works by this author on: Oxford Academic PubMed Google Scholar Paul Coninx Paul Coninx Service de Médecine On-cologique Institut Jean-GodinotReims, France.Joint Committee of Head and Neck CancerReims, France. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 5, 4 March 1992, Pages 348–351, https://doi.org/10.1093/jnci/84.5.348 Published: 04 March 1992 Article history Received: 27 September 1991 Revision received: 26 November 1991 Accepted: 02 December 1991 Published: 04 March 1992
Tangier Disease With Continuous Massive and Longitudinal Diffuse Calcification in the Coronary Arteries
Authors: Ryutaro Komuro, Shizuya Yamashita, Satoru Sumitsuji, Ken-ichi Hirano, Takao Maruyama, Makoto Nishida, Fumihiko Matsuura, Akifumi Matsuyama, Taizo Sugimoto, Noriyuki Ouchi, Naohiko Sakai, Tadashi Nakamura, Toru Funahashi, Yuji Matsuzawa
Journal: Circulation (2000)
Chronic arterial responses to stent implantation: A serial intravascular ultrasound analysis of palmaz-schatz stents in native coronary arteries
Authors: Rainer Hoffmann, Gary S. Mintz, Jeffrey J. Popma, Lowell F. Satler, Augusto D. Pichard, Kenneth M. Kent, Carol Walsh, Paul Mackell, Martin B. Leon
Journal: Journal of the American College of Cardiology (1996)
Afterload as a predeterminant of haemodynamics and segmental wall motion following coronary artery occlusion
Authors: E. L. FALLEN, W. S. BEATTIE, G. A. TAIT, J. A. CAIRNS
Journal: Cardiovascular Research (1979)

Maximal changes in haemodynamics and segmental wall motion were seen 2 min after coronary occlusion and were examined in relation to the loading conditions of the left ventricle before occlusion in 20 open chest dogs. There was a significant inverse relationship between the preligation mean aortic pressure and the percentage decrease in stroke volume following ligation. This relationship was observed whether afterload was distributed randomly (mean aortic pressure ranging from 9.7 to 17.6 kPa [73 to 132 mmHg]) between all dogs (r = 0.65; P less than 0.001) or altered by methoxamine (+4 kPa [+30 mmHg]) and nitroprusside (-3.2 kPa [-24 mmHg]) within the same dog (r = 0.82; P less than 0.001; n = 8). Although occlusion of the anterior descending artery caused a small (+5.5%) but significant increase in end-diastolic length of the non-ischaemic epicardial segment, the capacity for compensatory ventricular dilatation was not dependent on preligation afterload. However, the capacity of the ischaemic segment to undergo systolic expansion was significantly greater (+30.2% of end-systolic segment length) in those dogs with the lowest preligation MAP (8 to 12 kPa [60 to 90 mmHg]) compared with systolic lengthening of only 15.8% in the high afterload group (15 to 18 kPa [112 to 135 mmHg]). These data indicate that the loading conditions of the left ventricle predetermine the extent of global and segmental left ventricular dysfunction during the early phase of acute ischaemic injury.
Computer-assisted Hydrodynamic Gene Delivery
Authors: Takeshi Suda, Kieko Suda, Dexi Liu
Journal: Molecular Therapy (2008)

The recently developed hydrodynamic delivery method makes it possible to deliver DNA and RNA into parenchyma cells by intravascular injection of nucleic acid–containing solution. While this procedure is effective in rodents, it is difficult to perform in large animals, because manual control while delivering the injection cannot be sufficiently reliable for achieving a just-right hydrodynamic pressure in targeted tissue. In order to overcome this problem, we have developed a computer-controlled injection device that uses real-time intravascular pressure as a regulator. Using the new injection device, and mouse liver as the model organ, we demonstrated continuous injection at a single pressure and different pressures, and also serial (repeated) injections at intervals of 250 ms, by programming the computer according to the need. When assessed by reporter plasmids, the computer-controlled injection device exhibits gene delivery efficiency similar to that of conventional hydrodynamic injection. The device is also effective in gene delivery to kidney and muscle cells in rats, with plasmids or adenoviral vectors as gene carriers. Successful gene delivery to liver and kidney was also demonstrated in pigs, with the computer-controlled injection being combined with image-guided catheterization. These results represent a significant advance in in vivo gene delivery research, with potential for use in gene therapy in humans. The recently developed hydrodynamic delivery method makes it possible to deliver DNA and RNA into parenchyma cells by intravascular injection of nucleic acid–containing solution. While this procedure is effective in rodents, it is difficult to perform in large animals, because manual control while delivering the injection cannot be sufficiently reliable for achieving a just-right hydrodynamic pressure in targeted tissue. In order to overcome this problem, we have developed a computer-controlled injection device that uses real-time intravascular pressure as a regulator. Using the new injection device, and mouse liver as the model organ, we demonstrated continuous injection at a single pressure and different pressures, and also serial (repeated) injections at intervals of 250 ms, by programming the computer according to the need. When assessed by reporter plasmids, the computer-controlled injection device exhibits gene delivery efficiency similar to that of conventional hydrodynamic injection. The device is also effective in gene delivery to kidney and muscle cells in rats, with plasmids or adenoviral vectors as gene carriers. Successful gene delivery to liver and kidney was also demonstrated in pigs, with the computer-controlled injection being combined with image-guided catheterization. These results represent a significant advance in in vivo gene delivery research, with potential for use in gene therapy in humans.
Distribution of hepatitis G viremia and antibody response to recombinant proteins with special regard to risk factors in 709 patients
Authors: H Feucht, B Zollner, S Polywka, B Knodler, M Schroter, H Nolte, R Laufs
Journal: Hepatology (1997)

A new virus named hepatitis G virus (HGV) has been detected recently. Until now, no assays for the detection of antibodies against different HGV proteins have been commercially available. Therefore, a strip immunoblot assay has been established to investigate seroreactivity against recombinant structural (core) and nonstructural proteins (NS3 and NS4) of HGV produced in Escherichia coli. Seropositivity for HGV was evaluated and concordanced with HGV polymerase chain reaction (PCR) results in 709 subjects. These individuals were classified into a nonrisk or a risk group, on the basis of infection with human immunodeficiency virus (HIV) or hepatitis C virus (HCV) or frequent parenteral exposure, including hemophilia, intravenous drug addiction, receipt of blood transfusion, or hemodialysis. The nonrisk group consisted of 257 healthy blood donors with normal alanine transaminase (ALT) levels (ALT < 30 U/L) and 154 patients with suspected non-A-E hepatitis (ALT > 45 U/L). In the group of healthy blood donors, 1.9% (5 of 257) had detectable HGV viremia and 15.9% (41 of 257) showed antibody response to HGV. In the collective of patients with suspected non-A-E hepatitis, results from 1.9% of patients (3 of 154) were positive by HGV PCR, and 15.6% of patients (24 of 154) showed seropositivity against the recombinant HGV proteins. In six groups of patients (n = 298) with different risk factors, the prevalence of both HGV viremia (V) and serological reactivity (SR) was higher compared with that of the nonrisk group: V, 6.80%-35.2%; serological reactivity (SR), 25.4%-52.9%. The following conclusions can be derived from our data. HGV infection is widespread in the general population. The prevalence of antibodies against HGV or detectable HGV viremia is higher in patients with risk factors for parenteral viral transmission than in those without risk factors. The majority of HGV infections (70.2%) is self-limiting and not persistent in our collective of patients. We found no correlation between HGV viremia and clinical or biochemical signs of hepatitis in individuals without risk factors for acquiring parenterally transmitted agents.
Short- and long-term beneficial effects of a multidisciplinary therapy for the control of metabolic syndrome in obese adolescents
Authors: Danielle Arisa Caranti, Marco Túlio de Mello, Wagner L. Prado, Lian Tock, Kãli O. Siqueira, Aline de Piano, Mara C. Lofrano, Dejaldo M.J. Cristofalo, Henrique Lederman, Sérgio Tufik, Ana R. Dâmaso
Journal: Metabolism (2007)
Prevalence and significance of previously undiagnosed rheumatic diseases in pregnancy
Authors: Arsenio Spinillo, Fausta Beneventi, Véronique Ramoni, Roberto Caporali, Elena Locatelli, Margherita Simonetta, Chiara Cavagnoli, Claudia Alpini, Giulia Albonico, Elena Prisco, Carlomaurizio Montecucco
Journal: Annals of the Rheumatic Diseases (2012)

The objective of this study was to evaluate the rates of previously undiagnosed rheumatic diseases during the first trimester of pregnancy and their impact on the pregnancy outcome.Pregnant women in their first trimester were screened using a two-step approach using a self-administered 10-item questionnaire and subsequent testing for rheumatic autoantibodies (antinuclear antibody, anti-double-stranded DNA, anti-extractable nuclear antigen, anticardiolipin antibodies, anti-β2-glycoprotein I antibodies and lupus anticoagulant) and evaluation by a rheumatologist. Overall, the complications of pregnancy evaluated included fetal loss, pre-eclampsia, gestational diabetes, fetal growth restriction, delivery at less than 34 weeks, neonatal resuscitation and admission to the neonatal intensive care unit.Out of the 2458 women screened, the authors identified 62 (2.5%) women with previously undiagnosed undifferentiated connective tissue disease (UCTD) and 24 (0.98%) women with previously undiagnosed definite systemic rheumatic disease. The prevalences were seven (0.28%) for systemic lupus erythematosus and Sjogren's syndrome, six (0.24%) for rheumatoid arthritis, three (0.12%) for antiphospholipid syndrome and one (0.04%) for systemic sclerosis. In multiple exact logistic regression, after adjustment for potential confounders, the OR of overall complications of pregnancy were 2.81 (95% CI 1.29 to 6.18) in women with UCTD and 4.57 (95% CI 1.57 to 13.57) in those with definite diseases, respectively, compared with asymptomatic controls.In our population approximately 2.5% and 1% of first trimester pregnant women had a previously undiagnosed UCTD and definite systemic rheumatic disease, respectively. These conditions were associated with significant negative effects on the outcome of pregnancy.
PHARMACOLOGICAL STUDIES IN CUTANEOUS INFLAMMATION IN MAN USING AN IN VIVO PERFUSION METHOD
Authors: M. W. GREAVES, JORGEN SONDERGAARD
Journal: British Journal of Dermatology (1970)

Journal Article PHARMACOLOGICAL STUDIES IN CUTANEOUS INFLAMMATION IN MAN USING AN IN VIVO PERFUSION METHOD Get access M. W. GREAVES, M. W. GREAVES University Department of Dermatology, Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar JØRGEN SØNDERGAARD JØRGEN SØNDERGAARD University Department of Dermatology, Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 82, Issue s6, 1 June 1970, Page 82, https://doi.org/10.1111/j.1365-2133.1970.tb08010.x Published: 01 June 1970
Beware of Temptations!
Authors: J. L. Thompson
Journal: JAMA (1898)

Indianapolis, May 13, 1898. <h3>To the Editor:</h3> —From the enclosed letter you can readily see what temptations await us at the Denver meeting: Editorial Rooms of<i>The Denver Republican</i>. Willis S. Thompson, City Editor. Denver, Colo., May 10, 1898. <h3>Dear Sir:</h3> —Will you please send us, by the earliest mail convenient, a good photograph of yourself? We wish to secure it as far in advance of the June Convention as possible, and we will guarantee its return in good condition. Yours very truly, Willis S. Thompson, City Editor. P. S. Kindly write full name and address on back of photo. If our fellow members yield to this pernicious way of advertising themselves in the newspapers ourAssociationmust eventually become a society of advertising idiots. We have no excuse whatever for this. Quacks have no other way to keep themselves before the public. Please sound a friendly note of warning
Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners
Authors: Fernando D. Camargo, Milton Finegold, Margaret A. Goodell
Journal: Journal of Clinical Investigation (2004)

Several recent reports have demonstrated that transplantation of bone marrow cells can result in the generation of functional hepatocytes. Cellular fusion between bone marrow–derived cells and host hepatocytes has been shown to be the mechanism of this phenomenon. However, the exact identity of the bone marrow cells that mediate cellular fusion has remained undetermined. Here we demonstrate that the hematopoietic progeny of a single hematopoietic stem cell (HSC) is sufficient to produce functional hepatic repopulation. Furthermore, transplantation of lymphocyte-deficient bone marrow cells and in vivo fate mapping of the myeloid lineage revealed that HSC-derived hepatocytes are primarily derived from mature myelomonocytic cells. In addition, using a Cre/lox–based strategy, we directly demonstrate that myeloid cells spontaneously fuse with host hepatocytes. Our findings raise the possibility that differentiated myeloid cells may be useful for future therapeutic applications of in vivo cellular fusion.
CD45RA depletion in HLA-mismatched allogeneic hematopoietic stem cell transplantation for primary combined immunodeficiency: A preliminary study
Authors: Fabien Touzot, Bénédicte Neven, Liliane Dal-Cortivo, Aurélie Gabrion, Despina Moshous, Guilhem Cros, Maryline Chomton, Jean-Marc Luby, Brigitte Terniaux, Jérémy Magalon, Capucine Picard, Stéphane Blanche, Alain Fischer, Marina Cavazzana
Journal: Journal of Allergy and Clinical Immunology (2014)