tbuckley/cabot-search huggingface dataset:
Talking Books for the Blind
Authors: Frank J. Weinstock
Journal: JAMA (1970)

<h3>To the Editor:—</h3> The letter, "Auditory Reading Matter for the Blind" (<b>210:</b>556, 1969), by C. S. Potter which suggested that blind or visually handicapped individuals be referred to rehabilitative services is important. The most expedient way for patients to obtain the auditory reading matter, called talking books, requires only a simple statement on a prescription blank or similar official stationery that an individual cannot use or read ordinary printed matter because of visual or physical limitations (eg, inability to hold a book or turn pages). It is not necessary to work through a rehabilitative services agency. To enable a patient to receive a free record player and records of books and magazines from regional libraries, the certification note can be sent to: Division of Blind and Physically Handicapped Library of Congress Washington, DC 20542 Patients may be certified by ophthalmologists or other physicians, optometrists, heads of agencies, nurses, occupational
Pressure controlled ventilation in ARDS
Authors: M. Lessard, E. Guerot, C. Mariette, A. Harf, F. Lemaire, L. Brochard, I. Vallverdú, G. Domínguez, E. Bak, A. Ortiz, M. Subirana, S. Benito, A. Net, J. Mancebo, J. Muñoz, J. E. Guerrero, J. L. Escalante, R. Palomino, P. Albert, C. S. V. Barbas, M. B. P. Amato, F. R. T. Plastino, C. J. Fernandes, N. Akamine, E. Knobel, J. Kesecioǵlu, L. Telci, F. Esen, T. Denkel, K. Akpir, A. S. Tütüncü, W. Erdmann, B. Lachmann, A. Mercat, L. Graini, F. Lenique, J. Dépret, J. L. Teboul, Ch. Richard
Journal: Intensive Care Medicine (1992)
Virus Markers in Multiple Sclerosis
Authors: Martin S. Hirsch
Journal: New England Journal of Medicine (1976)

Over the past 20 years, many diagnostic tests for multiple sclerosis have been described. However, none of them have proved to be specific for the diagnosis, which still rests on varied neurologic symptoms and signs occurring in characteristic remissions and exacerbations.In the present issue of the Journal, Levy and Auerbach describe a blood test based on the adherence of peripheral blood lymphocytes to measles virus–infected tissue culture cells. Purified populations of lymphocytes from patients with multiple sclerosis formed rosettes in vitro when mixed with measles-virus–infected epithelial cells. Similarly prepared lymphocytes from control populations showed much less rosetting activity; . . .
Prostaglandin E2 resistance in granulocytes from patients with aspirin-exacerbated respiratory disease
Authors: Tanya M. Laidlaw, Anya J. Cutler, Molly S. Kidder, Tao Liu, Juan Carlos Cardet, Heng Chhay, Chunli Feng, Joshua A. Boyce
Journal: Journal of Allergy and Clinical Immunology (2014)
The efficacy of zidovudine is time limited
Authors: D. S. Berman
Journal: JAMA (1994)

To the Editor.  —Dr Lundgren and colleagues 1 report a survival advantage in the first year in patients who received zidovudine, with decreased survival in the third year. Since publication of the study, several patients have asked us if we had heard or read the news that AZT was of no benefit.  The study confirms previous studies that demonstrate a survival advantage in zidovudine-treated patients. 2 Other studies have shown slower progression of acquired immunodeficiency syndrome (AIDS) and fewer cases of dementia. 3,4 Lundgren et al explain the increased third-year mortality as an expected outcome, with patients having had their lives prolonged for the first 2 years.  Zidovudine might be of even more benefit than demonstrated in the study. Optimal dosage, aggressive prophylactic antibiotic therapy, and combination antiretroviral therapy might enhance the beneficial effects of zidovudine.  It is clear that zidovudine is of benefit and has limited side effects. 3
Ballot on GP contract postponed
Authors: L. Eaton
Journal: BMJ (2003)

A ballot of GPs in the United Kingdom on whether they are prepared to accept a new contract that would overhaul payment for primary care services is to be delayed, after the revelation that many GPs could be worse off—not better off—as a result.

The BMA formally announced the decision last Monday after a fraught weekend when it emerged that many association members would not earn any additional money, even if they fulfilled all the required quality performance targets.

One GP, Dr Peter Swinyard, who runs a practice in west Swindon, which is largely social housing, stands to …
Book Review Cancer Medicine Fourth edition. Edited by James F. Holland, Robert C. Bast, Jr., Donald L. Morton, Emil Frei III, Donald W. Kufe, and Ralph R. Weichselbaum. 3386 pp. in two volumes, illustrated. Baltimore, Williams &amp; Wilkins, 1996. $229. 0-683-04095-2 Encyclopedia of Cancer Edited by Joseph R. Bertino. 2134 pp. San Diego, Calif., Academic Press, 1996. $475. 0-12-093230-X
Authors: Volker Diehl, Andreas Engert
Journal: New England Journal of Medicine (1997)
William Harvey: Englishman
Authors: William B. Bean
Journal: JAMA (1962)

Kenneth Franklin has capped the keystone of his careers as an investigator of the circulation and as a devotee of William Harvey by a splendid, short, new, biographical study entitled<i>William Harvey: Englishman</i>. Professor Franklin had made a distinguished new translation of "De Motu Cordis" in time for the tricentenary of Harvey's death celebrated in 1957. Generations of British medical scholars have been taxed sorely to uncover new thoughts or new facts about William Harvey when the time for the annual Harveian oration comes around and some distinguished physician scurries about for subject matter for the oration, knowing that the long roll of past orations serves as a stark benchmark for comparison. This book begins with a discussion of various historical ideas about the blood, heart, lungs, and vessels which prevailed with varying degrees of inaccuracy and confusion until Harvey set the matter right. The latter-day claims by proponents of
In Vivo Evaluation of Dacron Velour as a Nonthrombogenic Surface
Authors: MICHAEL A. SHEA, ROBERT A. INDEGLIA, RICHARD L. VARCO, JESSE E. EDWARDS, EUGENE F. BERNSTEIN
Journal: Circulation (1968)

The healing properties of Dacron velour were evaluated after its implantation in the canine aorta, vena cava, and left atrial appendage. A high incidence of thrombosis was observed, both in sacrificed animals and those that died spontaneously. The thrombus was invariably tightly adherent to the wall of the graft. No evidence of peripheral embolization was apparent. Histologic examination did not reveal anything unique in the healing of Dacron velour but rather it conformed to the healing process previously described with other Dacron vascular prostheses.
Thrombotic Thrombocytopenic Purpura: The Systemic Clumping “Plague”
Authors: Joel L. Moake
Journal: Annual Review of Medicine (2002)

▪ Abstract In thrombotic thrombocytopenic purpura (TTP), a multimeric form of von Willebrand factor (vWf) that is larger than ordinarily found in the plasma causes systemic platelet aggregation under the high-shear conditions of the microcirculation. A divalent cation–activated, vWf-cleaving metalloprotease that metabolizes large vWf multimers to smaller forms in normal plasma is severely reduced or absent in most patients with TTP. The vWf-cleaving metalloprotease either is not produced or is defective in children with chronic relapsing TTP. When the enzyme is provided by the infusion of normal plasma, these patients remain free of TTP symptoms for about three weeks. An IgG autoantibody to the vWf-cleaving metalloprotease is found transiently in many adult patients with acute idiopathic, recurrent, and ticlopidine/clopidogrel-associated TTP. These patients require plasma exchange, i.e., concurrent replacement of the inhibited vWf-cleaving metalloprotease by plasma infusion and plasmapheresis. The vWf-cleaving metalloprotease is present in fresh-frozen plasma, in cryoprecipitate-depleted plasma (cryosupernatant), and in plasma that has been treated with solvent and detergent. The pathophysiology of platelet aggregation in bone marrow transplantation/chemotherapy–associated thrombotic microangiopathy, and in the hemolytic-uremic syndrome, is not established. In neither condition is there a severe decrease in plasma vWf–cleaving metalloprotease activity.
DIOSCOREA VILLOSA—WILD YAM
Authors: JOHN V. SHOEMAKER
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quinidine-Digoxin Interaction
Authors: Darryl S. Rich
Journal: JAMA (1979)

<h3>To the Editor.—</h3> We wish to comment on the correspondence regarding the article "Interaction Between Quinidine and Digoxin" by Leahey et al (240:533, 1978) and the subsequent letters by Matzke and Burke (241:881, 1979) and Robert M. Cisneros, MS (241:881, 1979). On the basis of our work, we support the position of Leahey et al with respect to the quinidine-digoxin interaction. We conducted a study during a six-week period on 47 patients who were receiving digoxin. A pharmacokinetic computer program was used, similar to the one developed by Sheiner et al,<sup>1,2</sup>which used the basic equations for digoxin clearance derived by Koup et al.<sup>3</sup>The computer model error (defined as the square of the difference between the computer predicted level and the observed level as determined by radioimmunoassay) was considerably greater in the six patients receiving both quinidine and digoxin than it was in the 41 patients receiving digoxin
Sex, Hormones, and Hysterectomies
Authors: David S. Guzick, Kathleen Hoeger
Journal: New England Journal of Medicine (2000)

In this issue of the Journal, Shifren and coworkers1 postulate that the reduction in androgens resulting from bilateral oophorectomy is associated with sexual dysfunction in some women and that testosterone replacement can reverse this decline in sexual function and also improve psychological well-being. The potential importance of these postulates is substantial.Recent survey data suggest that the prevalence of sexual dysfunction among women in the United States is approximately 40 percent.2 Many of these women have had hysterectomies, about 600,000 of which are performed here annually.3 Bilateral oophorectomy is performed in conjunction with hysterectomy in about half of women 40 . . .
Use of acyclovir to treat chickenpox in pregnancy
Authors: K Boyd, E Walker
Journal: BMJ (1988)

Cholesterol embolism in a renal graft after treatment with streptokinaseThe clinical features of cholesterol embolism in the kidney have been well delineated.'We report a case of acute renal graft failure due to cholesterol emboli.We further suggest that fibrinolytic treatment caused the disease and draw attention to this potential complication of an increasingly popular treatment of myocardial infarction.2 3 Case report A 56 year old man was admitted to hospital with chest pain that had lasted four hours.Nineteen years earlier he had received a cadaver kidney transplant after a 20 year history of chronic glomerulonephritis with hypertension.No rejection occurred.Serum creatinine concentration was stable at 150 [smol/l.
31P-nuclear magnetic resonance studies of chronic myocardial ischemia in the Yucatan micropig.
Authors: D P Rath, M Bailey, H Zhang, Z Jiang, A M Abduljalil, S Weisbrode, R L Hamlin, P M Robitaille
Journal: Journal of Clinical Investigation (1995)

In this work, an x-irradiation/high fat/high cholesterol diet-induced atherogenic model was invoked to examine the effects of severe diffuse atherosclerosis on myocardial metabolism in the in vivo porcine heart. This model was studied using spatially localized 31P-nuclear magnetic resonance (NMR) to monitor pH and the levels of inorganic phosphate, phosphomonoesters, creatine phosphate, and adenosine triphosphate as a function of workload transmurally in control swine and in animals suffering from chronic ischemic heart disease. These preliminary studies revealed that the development of severe atherosclerosis and the accompanying chronically diseased state produce changes in high energy phosphates and that increases in rate pressure products result in demonstrable signs of ischemia in the myocardium which span the entire left ventricular wall. Ischemic changes include a global increase in inorganic phosphate and corresponding decreases in creatine phosphate, ATP, and pH. Importantly, changes in intracellular pH are noted with even the slightest increase in workload suggesting that these diseased hearts display elevated glycolytic activity. By challenging these animals with increased cardiac workload, we directly visualize how the chronically compromised heart responds to severe oxygen challenges in a clinically relevant model of this situation.
551 Assessment by Hycor RAST and pharmacia CAP of cross sensitization to banana and avocado among latex sensitive hospital employees
Authors: G ANDERSON, T LI, J MALKI, A PATEL, M ALEM, A BABAKHIN, G CIESLEWICZ, I ZAKIROVA, H NOLTE, J BOYCE
Journal: Journal of Allergy and Clinical Immunology (1996)
Use of exercise tests in assessment of the functional result of aortocoronary bypass surgery
Authors: I Y Luksic, J A Raffo, D A S G Mary, D A Watson, P B Deverall, R J Linden
Journal: Thorax (1981)

The value of an objective exercise test for the assessment of the functional results of aortocoronary bypass was investigated in 19 patients who were studied before and six months after the operation. For positive tests the end point was defined as a net ST segment depression of 0·1 mv 80 ms after the J point of the ECG. For negative tests the end point was 85% of the age-predicted maximal heart rate response. One patient who was not able to attain either of these points after the operation was excluded. In the remaining 18 patients three indices were used in the analysis. First, the heart rate (HR) and the product of heart rate and systolic blood pressure (RPP) were measured at the defined level of ST segment depression during positive exercise tests to yield HR/ST and RPP/ST threshold respectively. Second, the HR and RPP were measured at the end point of the negative tests. Third, the duration of exercise till the end point of the tests was measured. In each patient the duration of the postoperative test was longer than that of the preoperative test. While all the patients had a positive exercise test before the operation, the test was negative in 11 after it. In 10 of these 11 patients the HR and RPP attained at the end point of the postoperative test had increased; the HR and RPP remained unchanged in one patient. Positive tests were still present in seven of the 18 patients. In five of these the HR/ST threshold and RPP/ST threshold were greater after than before operation, and they remained unchanged in two. An improvement in myocardial blood supply after aortocoronary bypass was suggested indirectly by the ability to attain, during exercise, a higher HR and RPP at the end point of the test. The test proved especially valuable in patients who retained a positive exercise test after the operation.
Effect of glucagon on the transmembrane potential, contraction, and ATPase activity of the failing human heart
Authors: K. PRASAD
Journal: Cardiovascular Research (1972)

The effects of glucagon (5, 10, 20, and 50 μg/ml.) on the simultaneously recorded transmembrane potentials and contractions; and (Na+—K+)-ATPase activity of 24 papillary muscles obtained from 24 patients undergoing corrective open heart surgery were investigated. Glucagon in all the concentrations produced an increase in the force of contraction associated with a shortening of the action potential duration in two papillary muscles obtained from patients suffering from mild heart failure. The maximal percent increases in contraction produced by 5, 10, 20, and 50 (μg/ml. glucagon were 15 ± 4 (SD), 25 ± 3·5, 42 ± 4, and 44 ± 4 respectively. Glucagon did not produce any significant change in the transmembrane potential in 18 papillary muscles obtained from patients suffering from chronic heart failure. (Na+—K+)-ATPase activity of human papillary muscle was found to be 21·53 ± 1·37 (SE) μ-mole/mg protein/hr. Glucagon in none of the concentrations produced any significant change in the Na+—K+-ATPase activity. These results indicated that glucagon might not be effective in the chronic heart failure because it did not increase the contractility in such muscles. Also glucagon induced positive inotropic effect seems to be associated with a shortening of the action potential duration.
Abstract 28: The Netrin-1 receptor UNC5C is a tumor suppressor in colorectal malignancies
Authors: Marie-May Coissieux, Jerneja Tomsic, Christine Lasset, Heather Hampel, Jean-Yves Scoazec, Qing Wang, Stephan M. Tanner, Agnès Bernet, Albert de la Chapelle, Patrick Mehlen
Journal: Cancer Research (2012)

Abstract The Netrin-1 receptors UNC5A, B and C belong to the functional family of dependence receptors that share the ability to induce apoptosis in the absence of their ligands. Such a trait has been hypothesized to confer a tumor suppressor activity to these receptors. Expression of one of these dependence receptors at the surface of a tumor cell is thus speculated to render this cell dependent on ligand for its survival, hence inhibiting cell proliferation or migration outside the ligand availability zone. Here we show that the expression of the UNC5C gene is down-regulated in colorectal cancers, mainly because of tumor-associated specific promoter methylation. In addition, inactivation of UNC5C in mice is associated with increased intestinal tumor progression, demonstrating its tumor suppressor role. Moreover, mutations in UNC5C that turn down the pro-apoptotic activity of the receptor are found in patients with familial form of colorectal cancer. This germline coding mutation in UNC5C has been detected in five different families from France and USA and co-segregates with the disease. We further, determine that this anti-apoptotic mutation arose from a common founder. In summary, our study strongly indicates that the genetic inactivation of the tumor suppressor UNC5C may be a major promoter of familial predisposition to colorectal tumorigenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 28. doi:1538-7445.AM2012-28
Excessively Enlarged Right Coronary Artery Aneurysm With Intramural Thrombus Causing Recurrent Acute Coronary Syndrome
Authors: Tomoyuki Honjo, Junya Ejiri, Yoshihiro Sasaki, Sonoko Hirayama, Hiroshi Takaishi, Yoshitaka Ohashi, Shinobu Ichikawa, Kojiro Awano
Journal: Circulation (2008)
Abstract 18: Molecular characterization of Brazilian patients suspected for Lynch syndrome
Authors: Felipe C. Silva, Giovana T. Torrezan, Márcia CP Figueiredo, Jose Roberto O. Ferreira, Érika M. Santos, Wilson T. Nakagawa, Samuel Aguiar-Junior, Benedito M. Rossi, Fabio O. Ferreira, Dirce M. Carraro
Journal: Cancer Research (2014)

Abstract Lynch syndrome (LS), former known as Hereditary Non Polyposis Colorectal cancer (HNPCC), accounts for 3-5% of all colorectal cancers (CRC) and is inherited in an autossomal dominant fashion. This syndrome is characterized by early CRC onset, high incidence of tumors in the ascending colon, excess of synchronous and metachronous tumors, and accelerated transition adenoma-carcinoma (2-3 years). Nowadays, LS is regarded of patients who carry deleterious germline mutations in one of the five Mismatch repair genes, such as MutL homolog 1 (MLH1), MutS homolog 2 (MSH2), MutS homolog 6 (MSH6), post-meiotic segregation increased 1 (PMS1) or post-meiotic segregation increased 2 (PMS2). In order to characterize Brazilian patients suspect for LS, we assessed the frequency of germline point mutations in MSH6, PMS1 and PMS2 in patients negative for point mutations in MLH1 and MSH2 by capillary sequencing. We also assessed chromosomal deletions in MLH1 and MSH2 and MSH6 generating a complete characterization of MMR genes. The analysis of the five MMR genes revealed 46 carriers of pathogenic mutations, including 25 in MSH2 (54%), 16 in MLH1 (35%), 4 in MSH6 (9%) and one in PMS2 (2%) gene In addition, from the 70 negative patients, we selected one mutation negative family that met the stringent Amsterdam criteria (AC) for whole exome sequencing using the SOLID platform. For this family, we selected 5 close blood relatives, including 3 affected and 2 unaffected individuals in order to facilitate the identification of new susceptibility genes with autosomal dominant pattern. The results revealed two candidate genes, c-KIT and WDR27 that segregated with the disease. Additional analysis are under evaluation. Citation Format: Felipe C. Silva, Giovana T. Torrezan, Márcia CP Figueiredo, Jose Roberto O. Ferreira, Érika M. Santos, Wilson T. Nakagawa, Samuel Aguiar-Junior, Benedito M. Rossi, Fabio O. Ferreira, Dirce M. Carraro. Molecular characterization of Brazilian patients suspected for Lynch syndrome. [abstract]. In: Proceedings of the AACR Special Conference: Cancer Susceptibility and Cancer Susceptibility Syndromes; Jan 29-Feb 1, 2014; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(23 Suppl):Abstract nr 18. doi:10.1158/1538-7445.CANSUSC14-18
Doctor who treated torture victims in Iraq is suspended for 12 months
Authors: C. Dyer
Journal: BMJ (2013)

An Iraqi doctor who treated detainees of Saddam Hussein’s regime during his compulsory military service 20 years ago has been suspended from practice in the United Kingdom for 12 months for complicity in torture.

The Medical Practitioners Tribunal Service in Manchester held that Mohammed Al-Byati, 47, knew that the patients he treated had been tortured and must have known that they would be violently interrogated again.

But the panel decided not to end his career by erasing him from the medical register, after accepting that he played no part in the torture and had effectively no choice …
Hemolysis is associated with acute kidney injury during major aortic surgery
Authors: Iris C. Vermeulen Windsant, Maarten G. Snoeijs, Sebastiaan J. Hanssen, Sibel Altintas, John H. Heijmans, Thomas A. Koeppel, Geert Willem H. Schurink, Wim A. Buurman, Michael J. Jacobs
Journal: Kidney International (2010)