Cephalothin-Induced Granulocytopenia
Authors: Mario-Antoine Dicato, Leonard Ellman
Journal: Annals of Internal Medicine (1975)

Letters1 November 1975Cephalothin-Induced GranulocytopeniaMARIO-ANTOINE DICATO, M.D., LEONARD ELLMAN, M.D.MARIO-ANTOINE DICATO, M.D.Search for more papers by this author, LEONARD ELLMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-5-671 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince its introduction in 1962, cephalothin (Keflin®) has assumed a major role in the therapy of bacterial infection. There have been only sporadic reports of granulocytopenia caused by cephalothin therapy (1-3). The appearance of four such cases in a 1-year period has prompted us to report the experience at our institution.A computer survey of hospital discharge summaries for 1974 was done, and all cases reported as neutropenia or granulocytopenia secondary to medication were reviewed. Criteria for study included a granulocyte count of less than 1000/mm3and absence of any other cause of neutropenia such as malignancy, collagen disease, hypersplenism,...References1. DAVISSIEGLMANHEWITT ASW: Neutropenic reaction to cephalothin therapy. Antimicrob Agents Chemother 1963, pp. 272-277 MedlineGoogle Scholar2. LEVINWEINERFUDENBERG ARH: Granulocytopenia caused by anti-cephalothin antibodies (abstract). Clin Res 19:424, 1971 Google Scholar3. SILBERDIOKNO SA: Agranulocytosis from cephalosporins (letter). JAMA 224:1427, 1973 CrossrefMedlineGoogle Scholar4. GRAFTARLOV MA: Agranulocytosis with monohistiocytosis associated with ampicillin therapy. Ann Intern Med 69:91-95, 1968 LinkGoogle Scholar5. MARKOWITZROTHKOPFHOLDEN SMF: Nafcillin-induced agranulocytosis. JAMA 232:1150-1152, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAgranulocytosis during antibiotic therapy: Drug sensitivity or sepsis?LIMITED-SPECTRUM (FIRST-GENERATION) CEPHALOSPORINSCephalosporin-induced immune cytopenia in the dog: Demonstration of erythrocyte-, neutrophil-, and platelet-associated igg following treatment with cefazedoneCephalosporin-induced Changes in the Ultrastructure of Canine Bone MarrowThe hematologic effects of cefonicid and cefazedone in the dog: A potential model of cephalosporin hematotoxicity in manThe hematopathology of cefonicid- and cefazedone-induced blood dyscrasias in the dogCephradine-Associated Immune NeutropeniaBone and joint infections caused by gram-positive bacteria: Treatment with cefotaximeCephalosporin-induced immune neutropeniaCefmenoxime: Clinical EvaluationAgranulocytosis associated with semisynthetic penicillins and cephalosporinesHemolytic Anemia and Pancytopenia Induced by CefoxitinNeutropenia Associated with CefotaximePenicillins and CephalosporinsReversible Acute Leukopenia and CefoxitinMARTIN SHANSKY, M.D., CAL W. GREENLAW, PHARM.D.Adverse reactions to anti-infective agentsDRUG-INDUCED IMMUNOLOGICAL NEUTROPENIACephalothin Induced Neutropenia during the Treatment of Bacterial EndocarditisSuppression of lymphocyte responses by cephalosporins 1 November 1975Volume 83, Issue 5Page: 671-672KeywordsCollagen diseasesComputersGranulocytesNeutropenia Issue Published: 1 November 1975 PDF DownloadLoading ...