tbuckley/cabot-search huggingface dataset:
A SIMPLE SPLINT FOR BASEBALL FINGER
Authors: Philip Lewin
Journal: JAMA (1925)

This is a simple splint which I have found very effective. It is useful in the treatment of baseball finger, mallet finger<sup>1</sup>or "drop phalangette,"<sup>2</sup>and arthritic flexion of the end phalanx. The principle may be useful in the treatment of hammer toe. It is made of aluminum, although duralumin, copper, brass, German silver or silver may be used. It is very light, self-retaining and easily adjustable to any position, including hyperextension. It is permeable to the roentgen ray, can be immersed in water, and is inexpensive. The splint can be made to fit so snugly that it must be "soaped" or wet to be removed, like a tight band ring. It can be worn under a glove, and one of my patients drives her car while wearing it. A pattern is made as shown in Figure 1. The pattern is then shaped to that of Figure 2
TCT-234 The Impact of Weekend and Holiday Versus Weekday Presentation on the Reperfusion Therapy and Clinical Outcomes in Acute Myocardial Infarction Patients
Authors: Hyun wook Lee, Shung Chull Chae, Myeong Chan Cho, Yoon Jung Choi, Kang Woon Choi, Taek Jong Hong, Seung-Ho Hur, Yang soo Jang, Myung Ho Jeong, Jung Hwan Jo, Sung Yun Jung, Sang Wook Kang, Su Mi Kim, Ung kim, Young Jo Kim, Tae Hun Kwon, Chan Hee Lee, Sang Hee Lee, Jong Seon Park, Seung-Jung Park, Won Jong Park, Ki-Bae Seung, Dong Gu Shin, Jang Won Son, In Hwan Song, Junghan Yoon
Journal: Journal of the American College of Cardiology (2013)
Reply to David R. Staskin and Michael G. Oefelein's Letter to the Editor re: Christopher R. Chapple, Vik Khullar, Zahava Gabriel, et al. The Effects of Antimuscarinic Treatments in Overactive Bladder: An Update of a Systematic Review and Meta-Analysis. Eur Urol 2008;54:543–62
Authors: Christopher Chapple
Journal: European Urology (2008)
Morbidity in patients with hidradenitis suppurativa
Authors: J.M. Von Der Werth, G.B.E. Jemec
Journal: British Journal of Dermatology (2001)

Background Although skin diseases are often immediately visible to both patients and society, the morbidity they cause is only poorly defined. It has been suggested that quality‐of‐life measures may be a relevant surrogate measure of skin disease. Hidradenitis suppurativa (HS) leads to painful eruptions and malodorous discharge and is assumed to cause a significant degree of morbidity. The resulting impairment of life quality has not previously been quantitatively assessed, although such an assessment may form a pertinent measure of disease severity in HS. Objectives To measure the impairment of life quality in patients with HS. Methods In total, 160 patients suffering from HS were approached. The following data were gathered: quality‐of‐life data (Dermatology Life Quality Index, DLQI questionnaire), basic demographic data, age at onset of the condition and the average number of painful lesions per month. Results One hundred and fourteen patients participated in the study. The mean ± SD age of the patients was 40·9 ± 11·7 years, the mean ± SD age at onset 21·8 ± 9·9 years and the mean ± SD duration of the disease 18·8 ± 11·4 years. Patients had a mean ± SD DLQI score of 8·9 ± 8·3 points. The highest mean score out of the 10 DLQI questions was recorded for question 1, which measures the level of pain, soreness, stinging or itching (mean 1·55 points, median 2 points). Patients experienced a mean of 5·1 lesions per month. Conclusions HS causes a high degree of morbidity, with the highest scores obtained for the level of pain caused by the disease. The mean DLQI score for HS was higher than for previously studied skin diseases, and correlated with disease intensity as expressed by lesions per month. This suggests that the DLQI may be a relevant outcome measure in future therapeutic trials in HS.
Functional Asplenia after Bone Marrow Transplantation
Authors: Peter Kalhs
Journal: Annals of Internal Medicine (1990)

Letters15 November 1990Functional Asplenia after Bone Marrow TransplantationPeter Kalhs, MD, Peter Kier, MD, Klaus Lechner, MDPeter Kalhs, MDSearch for more papers by this author, Peter Kier, MDSearch for more papers by this author, Klaus Lechner, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-10-805 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: We have shown previously that functional asplenia is a late complication of allogeneic bone marrow transplantation, occurring only in patients with extensive chronic graft-versus-host disease, and that the appearance of Howell-Jolly bodies in peripheral blood smears indicates functional asplenia (1). Because our previous study was retrospective, the exact onset of functional asplenia could not be determined. We therefore conducted a prospective study to determine the exact onset of functional asplenia and to confirm our previous findings.Twenty-six bone marrow transplant recipients (12 women, 14 men) with a median age of 33 years (range, 20 to 47 years)...Reference1. KalhsPanzerKletter PSK. Functional asplenia after bone marrow transplantation: a late complication related to extensive chronic graft-versus-host disease. Ann Intern Med. 1988;109:461-4. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Vienna Vienna 1090 Austria PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFunctional hyposplenism following allogeneic bone marrow transplantation.Applications of intravenous immunoglobulin in haematology 15 November 1990Volume 113, Issue 10Page: 805-806KeywordsBloodBone marrowBone marrow transplantationProspective studiesRetrospective studies Issue Published: 15 November 1990 PDF DownloadLoading ...
INJURY PREVENTION PRACTICE IN FEMALE BASKETBALL PLAYERS IN THE JAPANESE TOP LEAGUE: AN INTERVENTIONAL STUDY OVER 7 SEASONS
Authors: Y Nagano, M Hori, Y Shimizu, S Takahashi, K Tsuda, H Miki, E Uchiyama
Journal: British Journal of Sports Medicine (2014)

Background Female basketball players are at a higher risk for injuries such as those of the anterior cruciate ligament (ACL). Therefore, preventing such injuries is essential for their health and the competition. Objective To assess the effect of an injury prevention training program on the incidence of injuries in female basketball players. Design Prospective intervention study. Setting Top-level basketball league in Japan. Participants A total of 1127 players from 12 top-league teams during 7 seasons. Interventions From the middle of the second (2007–2008) season, a 3-step injury prevention program was initiated. The program focused on strength, balance, jump-landing techniques, and basketball skills. Subjects were instructed to perform exercises in a neutral position and to avoid lumbar lordosis, rear axial weight bearing, hip adduction, and knee valgus. Main outcome measurements All injuries, including ACL injury and ankle sprain, occurring during the 7 seasons that caused a player to miss a current session and/or miss a subsequent session were recorded. Injury incidences were calculated in terms of per 1000 player hours (PH). Compliance with the program was also reported. Results During 7 seasons, 8,73,084 PH and 973 injuries were reported. The injury incidence was 1.11/1000 PH, which did not significantly change after the intervention. In each season, ankle or knee injuries were most frequent. 34 non-contact ACL injuries occurred, an incidence of 0.039/1000 PH. During 5 seasons after the intervention, the incidence of non-contact ACL injuries in the team conducting the prevention program was 0.032, while the team without the program had an incidence of 0.046. A total of 235 ankle sprains occurred, an incidence of 0.269/1000 PH. After the intervention, the incidence decreased to 0.19 in the 2011–2012 season. Conclusions The results show that the injury prevention program may decrease the frequency of non-contact ACL injuries and ankle sprains.
Reduced cardiac mass by nitrendipine is dissociated from systemic or regional haemodynamic changes in rats
Authors: I. KOBRIN, S. SESOKO, B. L PEGRAM, E. D FROHLICH
Journal: Cardiovascular Research (1984)

Journal Article Reduced cardiac mass by nitrendipine is dissociated from systemic or regional haemodynamic changes in rats Get access ISAAC KOBRIN, ISAAC KOBRIN From the Salmen Family Hypertension Research Laboratory, Research Division, Alton Ochsner Medical Foundation, New Orleans, Louisiana Search for other works by this author on: Oxford Academic PubMed Google Scholar SHOJI SESOKO, SHOJI SESOKO From the Salmen Family Hypertension Research Laboratory, Research Division, Alton Ochsner Medical Foundation, New Orleans, Louisiana Search for other works by this author on: Oxford Academic PubMed Google Scholar BARBARA L PEGRAM, BARBARA L PEGRAM From the Salmen Family Hypertension Research Laboratory, Research Division, Alton Ochsner Medical Foundation, New Orleans, Louisiana Search for other works by this author on: Oxford Academic PubMed Google Scholar EDWARD D FROHLICH EDWARD D FROHLICH * From the Salmen Family Hypertension Research Laboratory, Research Division, Alton Ochsner Medical Foundation, New Orleans, Louisiana *Address for reprint requests: Edward D Frohlich, MD, Vice President, Education and Research, Alton Ochsner Medical Foundation, 1516 Jefferson Highway, New Orleans, Louisiana 70121, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 18, Issue 3, March 1984, Pages 158–162, https://doi.org/10.1093/cvr/18.3.158 Published: 01 March 1984
Abstract IA19: Small-molecule modulators of the Hedgehog signaling pathway
Authors: James K. Chen
Journal: Cancer Research (2012)

Abstract The Hedgehog (Hh) signaling pathway plays critical roles in embryonic patterning and tissue homeostasis, and its inappropriate activation can lead to basal cell carcinoma, medulloblastoma, and other cancers. Small molecules that modulate Hh signaling proteins can therefore be valuable probes of Hh pathway-dependent physiology and targeted therapies for Hh pathway-related diseases. While high-throughput screening campaigns in academia and industry have yielded several Hh pathway modulators that potently and selectively target the transmembrane protein Smoothened (Smo), there is a growing need for compounds that inhibit Hh target gene expression through other mechanisms. Such small molecules could provide new insights into the cellular processes that regulate Gli transcription factor function and possibly prevent or overcome the emergence of tumors that are resistant to Smo antagonists. Toward this goal, we have completed large-scale screens for Hh pathway inhibitors that act downstream of Smo, revealing several compounds that inhibit Gli-dependent transcription through distinct mechanisms of action. We have successfully determined the cellular target of one inhibitor from our screens, and mechanistic studies of other Gli antagonists are currently underway. Citation Format: James K. Chen. Small-molecule modulators of the Hedgehog signaling pathway [abstract]. In: Proceedings of the AACR Special Conference on Chemical Systems Biology: Assembling and Interrogating Computational Models of the Cancer Cell by Chemical Perturbations; 2012 Jun 27-30; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2012;72(13 Suppl):Abstract nr IA19.
Antihypertensive Therapy -- Efficacy and Quality of Life
Authors: Suzanne Oparil
Journal: New England Journal of Medicine (1993)

In the 20 years since the creation of the National High Blood Pressure Education Program, remarkable progress has been made in detecting and treating hypertension in the United States1. The number of patients with hypertension who are aware of their condition has increased dramatically, from 51 percent in 1971 to 1972 to 84 percent in 1988 to 19912,3. The percentage of patients with hypertension who are taking medication has increased from 36 percent to 73 percent over the same period, and the percentage whose blood pressure is controlled by medication has also increased greatly, although the latter . . .
Cutaneous Vasculitis Associated with Mefloquine
Authors: White A. Clinton Jr.
Journal: Annals of Internal Medicine (1995)

Letters1 December 1995Cutaneous Vasculitis Associated with MefloquineWhite A. Clinton Jr., MD, Don A. Gard, MD, and Sandra L. Sessoms, MDWhite A. Clinton Jr., MDBaylor College of Medicine; Houston, TX 77030, Don A. Gard, MDBaylor College of Medicine; Houston, TX 77030, and Sandra L. Sessoms, MDBaylor College of Medicine; Houston, TX 77030Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-11-199512010-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Mefloquine is currently recommended as first-line chemoprophylaxis for malaria in travelers to areas where chloroquine-resistant malaria is present. We describe a 62-year-old woman in otherwise good health who traveled to Tanzania and Kenya for 2 weeks in October 1994. She began receiving mefloquine, 250 mg/wk, 1 week before departure. She developed pruritic petechiae on her lower extremities after ingesting the fourth of six scheduled doses. She received the fifth dose before medical evaluation. Examination showed lower-extremity edema and petechiae and two erythematous papular lesions on the right lateral leg (Figure 1). Mefloquine therapy was discontinued. The patient ...References1. Lobel HO, Miani M, Eng T, Bernard KW, Hightower AW, Campbell CC. Long-term malaria prophylaxis with weekly mefloquine. Lancet. 1993; 341:848-51. Google Scholar2. Steffen R, Fuchs E, Schildknecht J, Naef U, Funk M, Schlangenhauf P, et al. Mefloquine compared with other malaria chemoprophylactic regimens in tourists visiting east Africa. Lancet. 1993; 341:1299-303. Google Scholar3. Martin GJ, Malone JL, Ross EV. Exfoliative dermatitis during malaria prophylaxis with mefloquine. Clin Infect Dis. 1993; 16:341-2. Google Scholar4. Scerri L, Pace JL. Mefloquine-associated cutaneous vasculitis. Int J Dermatol. 1993; 32:517-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: Baylor College of Medicine; Houston, TX 77030 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMefloquineBiowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Mefloquine HydrochlorideAntiprotozoal and Anthelmintic AgentsCutaneous and Systemic Manifestations of Drug-Induced VasculitisDRUG-INDUCED VASCULITESLeukocytoclastic Vasculitis: Is Propranolol Implicated?Dermatological adverse effects with the antimalarial drug mefloquine: a review of 74 published case reportsMefloquine for Malaria Chemoprophylaxis 1992–1998: A ReviewMefloquine 1 December 1995Volume 123, Issue 11Page: 894KeywordsArthralgiaDrug therapyEdemaLesionsMalariaMefloquineMyalgiaProphylaxisRashesVasculitis ePublished: 15 August 2000 Issue Published: 1 December 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
CCL18 differentiates dendritic cells in tolerogenic cells able to prime regulatory T cells in healthy subjects
Authors: Imane Azzaoui, Saliha Ait Yahia, Ying Chang, Han Vorng, Olivier Morales, Ying Fan, Nadira Delhem, Coline Ple, André-Bernard Tonnel, Benoit Wallaert, Anne Tsicopoulos
Journal: Blood (2011)
TCTAP A-104 Real World Clinical Outcome of Drug-eluting Stent Implantation in Femoropopliteal Lesions
Authors: Masakazu Tsutsumi, Toshiya Muramatsu, Reiko Tsukahara, Yoshiaki Ito, Hiroshi Ishimori, Keisuke Hirano, Masatsugu Nakano, Masahiro Yamawaki, Motoharu Araki, Tamon Kato, Norihiro Kobayashi, Hideyuki Takimura, Yasunari Sakamoto, Shinsuke Mori, Hiroya Takafuji, Takahiro Tokuda, Makino Kenji
Journal: Journal of the American College of Cardiology (2014)
Thrombocytosis and leukocytosis interaction in vascular complications of essential thrombocythemia
Authors: Alessandra Carobbio, Guido Finazzi, Elisabetta Antonioli, Paola Guglielmelli, Alessandro M. Vannucchi, Federica Delaini, Vittoria Guerini, Marco Ruggeri, Francesco Rodeghiero, Alessandro Rambaldi, Tiziano Barbui
Journal: Blood (2008)
Inpatient Growth and Resource Use in 28 Children's Hospitals
Authors: Jay G. Berry, Matt Hall, David E. Hall, Dennis Z. Kuo, Eyal Cohen, Rishi Agrawal, Kenneth D. Mandl, Holly Clifton, John Neff
Journal: JAMA Pediatrics (2012)

To compare inpatient resource use trends for healthy children and children with chronic health conditions of varying degrees of medical complexity.
Comment on Gonvers, “Appropriateness and Diagnostic Yield of Upper Gastrointestinal Endoscopy”
Authors: G. Minoli, A. Prada
Journal: Endoscopy (1997)

See also: Appropriateness and Diagnostic Yield of Upper Gastrointestinal Endoscopy in an Open-Access Endoscopy UnitEndoscopy 1996; 28(08): 661-666DOI: 10.1055/s-2007-1005573
P33 'light Touch' Telemonitoring For People With Copd In Lothian: A Pilot Evaluation With Nested Qualitative Study
Authors: H. Pinnock, M. MacNab, S. Lee, L. McCloughan, J. Hanley, A. Lindsay, B. McKinstry
Journal: Thorax (2014)

<h3>Background and aim</h3> Professionally monitored telehealthcare has significant workload implications, but qualitative work suggested that pulse oximetry could potentially contribute to self-monitoring. We aimed to evaluate the acceptability and perceived utility of a COPD 'Light Touch' service. <h3>'Light Touch' intervention</h3> People with COPD used a pulse oximeter and symptom diary to self-monitor and self-refer according to a self-management plan. The service was overseen (though not actively monitored) by community-based respiratory/long-term conditions teams who were contactable by a telephone helpline. <h3>Method</h3> We undertook a before-and-after study with quantitative data collection at baseline and six-months. Outcomes were St George's Respiratory Questionnaire (SGRQ), Hospital Anxiety and Depression Scale (HADS) and service use. Nested semi-structured interviews with patients (at baseline and six-months) and managers, and a focus group of healthcare professionals explored perceptions of the service. <h3>Results</h3> We recruited 51 patients. Quality-of-Life (SGRQ): 21 (46%) participants improved by ≥4 (the minimum important difference); 12 (26%) deteriorated by ≥4. HADS improved: more participants had normal scores for anxiety (65%) and depression (80%) at 6 months than at baseline (51% and 64%). There were fewer surgery consultations and more telephone consultations, antibiotic, oral steroid and nebulised therapy prescriptions recorded during the study period compared to the previous year. Only 18 (39%) contacted the Light-Touch Helpline. We conducted interviews with 20 participants (36 interviews), 6 managers, and a focus group of 8 clinicians. Patients were generally positive and embraced 'Light-Touch' telemonitoring as part of their daily self-surveillance. The readings were reassuring and gave them confidence to make self-management decisions. Most patients did daily checks though several had stopped routine monitoring preferring to 'check their readings as and when the need arises'. Healthcare professionals were concerned that patients had disengaged with their service. Few patients contacted the clinical teams for help or advice during the study and 6-monthly telephone reviews were introduced to maintain contact. <h3>Conclusion</h3> 'In contrast to professionally-monitored telehealthcare, 'Light-Touch' seemed to reduce the contacts between patients and professionals. Whilst this may represent effective self-management, there were concerns that loss of engagement with healthcare services may be detrimental to achieving prompt management of exacerbations.
Multiple Plasmocytomas of the Liver and the Spleen
Authors: D GARFINKEL, F SALAMON, Y SIDI, M BEN-BASSAT, E LUBIN, J PINKHAS
Journal: Clinical Nuclear Medicine (1985)

Imaging in a patient with multiple myeloma and Gaucher's disease showed space-occupying lesions in the liver and spleen. These were found to be plasmocytomas on histologic examination.
Characterizing Sesame Allergy: Role of Specific IgE and Skin Prick Testing in Predicting Food Challenge Results
Authors: P. Permaul, L.M. Stutius, W.J. Sheehan, P.A. Rangsithienchai, J.E. Walter, F. Twarog, L.C. Schneider, W. Phipatanakul
Journal: Journal of Allergy and Clinical Immunology (2009)
Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetes
Authors: Shiao-Wei Shen, Gerald M. Reaven, John W. Farquhar
Journal: Journal of Clinical Investigation (1970)

A technique was devised for a more accurate measurement than has been heretofore possible of one of the factors responsible for hyperglycemia in the complex syndrome of diabetes. This factor is termed impedance and represents the tissues' insensitivity or resistance to insulin-mediated glucose uptake. It was measured by use of steady-state exogenous insulin and glucose infusions during a period of pharmacological suppression of endogenous insulin secretion. Endogenous new glucose production was also inhibited. Impedance as calculated is a direct function of steady-state glucose concentrations, since exogenous insulin concentrations were similar in all studies. Two groups of normal weight subjects were studied. One had maturity onset latent diabetes, and the other (matched for age, weight, and per cent adiposity) was normal. Impedance was closely reproducible in the same individual and remained relatively constant during prolonged infusions. The diabetics had average infusion glucose concentrations (and thus impedance) 68% higher than the normal group, and it is of note that their previously measured glucose intolerance differed by a similar degree; that is, the diabetic's intolerance (as defined by mean weighted plasma glucose response after oral glucose) was 52% greater than that of the normal individuals.
Ventilation-Perfusion Scintigraphy in an Adult with Congenital Unilateral Hyperlucent Lung
Authors: WILLIAM A. WEGENER, MICHAEL G. VELCHIK
Journal: Clinical Nuclear Medicine (1990)

A variety of congenital and acquired etiologies can give rise to the radiographic finding of a unilateral hyperlucent lung. An unusual case of congenital lobar emphysema diagnosed in a young adult following the initial discovery of a hyperexpanded, hyperlucent lung is reported. Although subsequent bronchoscopy and radiologic studies detailed extensive anatomic abnormalities, functional imaging also played an important role in arriving at this rare diagnosis. In particular, ventilation-perfusion scintigraphy identified the small contralateral lung as the functional lung and helped narrow the differential diagnosis to etiologies involving obstructive airway disorders.
In Vivo Low Density Lipoprotein Oxidation Relates to Coronary Reactivity in Young Men
Authors: Olli T. Raitakari, Olli-Pekka Pitkänen, Terho Lehtimäki, Sanni Lahdenperä, Hidehiro Iida, Seppo Ylä-Herttuala, Jukka Luoma, Kari Mattila, Tapio Nikkari, Marja-Riitta Taskinen, Jorma S.A. Viikari, Juhani Knuuti
Journal: Journal of the American College of Cardiology (1997)