tbuckley/cabot-search huggingface dataset:
DETECTION OF SPECIFIC ANTIGEN IN SV40-TRANSFORMED CELLS BY IMMUNOFLUORESCENCE
Authors: John H. Pope, Wallace P. Rowe
Journal: The Journal of Experimental Medicine (1964)

With an immunofluorescent technique involving the use of serum of hamsters with SV40 tumors, nuclear fluorescence was detected in each of five cell lines, derived from four mammalian species, transformed by SV40 virus. Essentially all nuclei, including those of multinuclear cells, were fluorescent-stainable. Serum of hamsters bearing SV40 tumors was also found to give nuclear fluorescence in susceptible cells (AGMK or BSC-1) acutely infected with SV40 virus. These findings provide further evidence that cellular incorporation of the SV40 viral genome, with partial expression of the genome by synthesis of at least one virus-specific antigen, is an integral property of all SV40 transformed cells.
P89 A decade on still not enough time for asthma
Authors: C. Mordaunt, S. J. Billington, M. G. Pearson, R. M. Angus
Journal: Thorax (2010)

<h3>Abstract</h3> The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children’s health in the United States. A cohort of n= 11,880 children aged 9-10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The study approximates the US population on several key sociodemographic variables, including sex, race, ethnicity, household income, and parental education. Data collected include assessments of health, mental health, substance use, culture and environment and neurocognition, as well as geocoded exposures, structural and functional magnetic resonance imaging (MRI), and whole-genome genotyping. Here, we describe the ABCD Study aims and design, as well as issues surrounding estimation of meaningful associations using its data, including population inferences, hypothesis testing, power and precision, control of covariates, interpretation of associations, and recommended best practices for reproducible research, analytical procedures and reporting of results.
Brain SPECT Imaging with Tc-99m HM-PAO in Creutzfeld-Jakob Disease
Authors: DAVID COHEN, YODPHAT KRAUSZ, ALEXANDER LOSSOS, EITAN BEN-DAVID, HENRI ATLAN
Journal: Clinical Nuclear Medicine (1989)

A Tc-99m HM-PAO brain SPECT study of a patient with biopsy-proven Creutzfeld-Jakob disease demonstrated perfusion defects in the left frontal and right temporoparietal areas. A brain CT was normal. The clinical potential of this imaging modality in the evaluation of dementia is discussed.
Bronchiectasis with<i>Mycobacterium avium</i>Complex Infection
Authors: Takae Ebihara, Hidetada Sasaki
Journal: New England Journal of Medicine (2002)

Figure 1. An 81-year-old woman was admitted with weight loss (18 kg in 27 months), hemoptysis, and tubular and diffuse granular shadows on her chest radiograph (Panel A). Physical examination demonstrated persistent, coarse rales and diffuse rhonchi throughout the lungs, clubbing, and cyanosis. A high-resolution computed tomographic (CT) scan of the lungs (Panel B) demonstrated the presence of bronchiectasis, with ectatic markings; mucoid impaction; multiple small, well-circumscribed pulmonary nodules, some of which had cavities; and granular shadows throughout the lungs. A three-dimensional image of the lungs that was reconstructed from the CT scan showed saccular and varicose ectatic bronchi (Panel . . .
Acyclovir-resistant chronic cutaneous herpes simplex in Wiskott-Aldrich syndrome
Authors: P. MODIANO, E. SALLOUM, M.N. GILLET-TERVER, A. BARBAUD, J.C. GEORGES, D. THOUVENOT, J.L. SCHMUTZ, M. WEBER
Journal: British Journal of Dermatology (1995)

Journal Article Acyclovir‐resistant chronic cutaneous herpes simplex in Wiskott‐Aldrich syndrome Get access P. MODIANO, P. MODIANO Department of Dermatology, Hôptical Fournier, 36 quai de la Bataille, 54000 Nancy, France Search for other works by this author on: Oxford Academic Google Scholar E. SALLOUM, E. SALLOUM Department of Dermatology, Hôptical Fournier, 36 quai de la Bataille, 54000 Nancy, France Search for other works by this author on: Oxford Academic Google Scholar M.N. GILLET‐TERVER, M.N. GILLET‐TERVER Department of Dermatology, Hôptical Fournier, 36 quai de la Bataille, 54000 Nancy, France Search for other works by this author on: Oxford Academic Google Scholar A. BARBAUD, A. BARBAUD Department of Dermatology, Hôptical Fournier, 36 quai de la Bataille, 54000 Nancy, France Search for other works by this author on: Oxford Academic Google Scholar J.C. GEORGES, J.C. GEORGES Microbiology Laboratory, Virology Division, Hôptical de Brabois, avenue de Bourgogne, 54500 Vandoeuvre, France Search for other works by this author on: Oxford Academic Google Scholar D. THOUVENOT, D. THOUVENOT Virology Laboratory, Grange Blanche Faculty of Medicine, 8 avenue Rockefeller, 69373 Lyon, Cedex, France Search for other works by this author on: Oxford Academic Google Scholar J.L. SCHMUTZ, J.L. SCHMUTZ Department of Dermatology, Hôptical Fournier, 36 quai de la Bataille, 54000 Nancy, France Search for other works by this author on: Oxford Academic Google Scholar M. WEBER M. WEBER Department of Dermatology, Hôptical Fournier, 36 quai de la Bataille, 54000 Nancy, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 133, Issue 3, 1 September 1995, Pages 475–478, https://doi.org/10.1111/j.1365-2133.1995.tb02682.x Published: 01 September 1995 Article history Accepted: 23 September 1994 Published: 01 September 1995
Identification of a new point mutation in the human molybdenum cofactor sulferase gene that is responsible for xanthinuria type II
Authors: Tetsuya Yamamoto, Yuji Moriwaki, Sumio Takahashi, Zenta Tsutsumi, Ka Tuneyoshi, Kiyoshi Matsui, Jidong Cheng, Toshikazu Hada
Journal: Metabolism (2003)
The Interface of Neurology &amp;amp; Internal Medicine
Authors: Douglas J. Lanska
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Incidence of Insulin-dependent Diabetes Mellitus in Israeli Children and Adolescents 0–20 Years of Age: A Retrospective Study, 1975–1980
Authors: Zvi Laron, Moshe Karp, Michaela Modan
Journal: Diabetes Care (1985)

A survey of the entire population of Israel revealed 392 newly diagnosed type I diabetic children and adolescents aged 0–20 for the period of 1975–80. The mean annual age specific incidence of type I (insulin-dependent) diabetes mellitus was 3.8/105 for the age group 0–14 yr and 4.2/105 for the age group 0–20 yr. The incidence among the Jews of Ashkenazi origin was 6.8 × 105 and that for Jews of non-Ashkenazi origin was 4.3 × 105, whereas that for the Arabs was 1.2 × 105. The overall incidence is lower than that reported for similar populations in most European countries, the USA, Canada, and New Zealand; similar to that reported for Arabs in Kuwait; and higher than only that found in Japan. The relative importance of environmental and genetic factors in the interpopulation differences in incidence of type I diabetes remains to be established.
GW25-e4362 Relation of high-sensitivity C-reactive protein and homo cysteine levels with recurrence of Paroxysmal atrial fibrillation after catheter ablation of atrial fibrillation
Authors: Jiang hua, Juxiang Li, Jian Hua Yu, Qi Chen, Huihui Bao, Jianxin Hu, Kui Hong, Yanqing Wu, Xiaoshu Cheng
Journal: Journal of the American College of Cardiology (2014)
The effect of vaccination with DNA encoding murine T‐cell epitopes on the Der p 1 and 2 induced immunoglobulin E synthesis
Authors: S. S. Kwon, N. Kim, T. J. Yoo
Journal: Allergy (2001)

Background: Immunization with naked plasmid DNA leads to strong and persistent cell‐mediated and humoral immune response to plasmid encoded antigen. Vaccination of DNA encoded whole allergen has been tried, but little information is currently available on the efficacy of DNA encoding T‐cell epitopes in allergic disease. The purpose of this study was to determine whether the vaccination of naked plasmid DNA encoding only T‐cell epitopes suppresses the allergic reaction as effectively as naked DNA encoding whole segments of allergen. Methods: We immunized mice with a mixed naked plasmid DNA encoding the five classes of murine T‐cell epitopes on Der p 1 and Der p 2 three times at weekly intervals via an intramuscular injection of BALB/c mice. Control mice were injected with the pcDNA 3.1 blank vector. After 3 weeks, the mice were actively sensitized twice and allowed to inhale the Der p extracts intranasally six times at weekly intervals. Results: The vaccinated mice showed a significant attenuated induction of Der p‐specific immunoglobulin E synthesis compared to controls. In terms of the Der p‐specific IgG2a antibody response, the vaccinated mice showed more prominent responses than the control mice group. In addition, analysis of the cytokine profile after Der p stimulation of the lymph‐node cells revealed that the level of the mRNA expression of the interferon‐γ gene was higher in the vaccinated mice than in the controls. Histologic studies showed a much reduced infiltration of inflammatory cells in lung tissue of the gene‐vaccinated mice in comparison with the controls. Conclusions: These results suggest that vaccination with DNA encoding T‐cell epitopes effectively inhibits allergen‐induced IgE synthesis and reduces cell infiltration in lung tissue. Thus, gene therapy using T‐cell epitope‐encoding DNA presents an ideal way of combating allergic disease in the future.
ST-segment variations after acute myocardial infarction. Relationship to clinical status.
Authors: M W Kronenberg, M Hodges, T Akiyama, D L Roberts, D A Ehrich, T L Biddle, P N Yu
Journal: Circulation (1976)

The degree of vectorcardiographic ST-segment elevation was employed as an index of myocardial ischemic injury in a study of 27 patients after acute myocardial infarction (AMI). The ST-segment vector magnitude (STVM) was derived from the continuously recorded modified Frank vectorcardiogram and was plotted serially by hours after onset of AMI. The STVM in normal subjects was 51.1 +/- 7.1 muV (mean +/- SE). A standard deviation of the pooled variance of 15.2 muV was obtained in a group of control patients and a change of more than 2 SD (greater than 30 muV) in an individual STVM was considered to be significant. The STVM progressively decreased in patients who survived without clinical complications while it remained elevated in those with congestive heart failure. A modest, sustained re-elevation of STVM was observed in patients who developed pericarditis, and a significant late average increase of 64 muV occurred in survivors with infarct extension. In contrast, STVM underwent a major increase in patients who died. In five of these six patients without associated pericarditis a mean increase of 164 muV was recorded in the last 5-12 hours of life. While death was clinically predictable in two patients with cardiogenic shock, it was not so for the four other patients who died. Thus, major increases in STVM frequently suggested significant new ischemic injury and were often premonitory to sudden death after AMI. The increases preceding death implied that not only ventricular extopy but also lethal conduction abnormalities after AMI might be ischemia-related.
Treatment of Lead Poisoning-Reply
Authors: David Rempel
Journal: JAMA (1990)

<h3>In Reply.—</h3> As indicated in the original article, the details of the therapeutic and diagnostic chelation presented represented one approach to chelation and the approach that we use at the University of California, San Francisco. Unfortunately, controlled and prospective studies that have evaluated various treatment protocols are lacking. Until such studies are done, there will be no single approach to chelation. The edetate disodium calcium leadmobilization test is a measure of total body burden of lead and is used in situations where symptoms of lead toxic reactions are more pronounced than would be expected based on the blood lead level. This situation may occur when blood lead levels are in the approximate range of 1.45 to 3.40 μmol/L, levels that correspond to higher 24-hour urine lead levels than presented in Dr Nadig's hypothetical example. Dr Nadig is correct in stating that doubling of very low 24-hour urine lead levels should
Pigs susceptible to energy metabolism in the fulminant hyperthermia stress syndrome.
Authors: C H Williams, C Houchins, M D Shanklin
Journal: BMJ (1975)

Pigs susceptible to the fulminant hyperthermia-stress syndrome spontaneously developed the hyperthermia syndrome. Basal metabolic rates 10-fold higher than normal were observed in these animals. The metabolic rate exceeded a 17-fold increase over normal with a total heat production of over 28.25 J (6;76 kcal) h-1 kg-1. Heat loss by radiation ceased early in the syndrome, possibly owing to intense peripheral vasoconstriction--a finding which suggests that in man vasodilators might have an important therapeutic role.
LONG-TERM OUTCOMES OF A HYBRID APPROACH OF PERCUTANEOUS CORONARY INTERVENTION FOLLOWED BY MINIMALLY INVASIVE VALVE SURGERY
Authors: Andres M. Pineda, Orlando Santana, Mery Cortes-Bergoderi, Christos Mihos, Nirat Beohar, Gervasio Lamas, Joseph Lamelas
Journal: Journal of the American College of Cardiology (2014)
Challenges to implementing NPfIT: Clinicians are becoming increasingly more influential
Authors: Tony M Penney
Journal: BMJ (2005)

Junior doctors' shifts and sleep deprivation New on-call rotas do not workEditor-Clearly the editorial by Murray et al on junior doctors' shifts has struck a chord with many, as on-call rotas are something close to many doctors hearts. 1 2 To most it seems the grass is not greener on the other side.Having worked most rotas, be it a traditional one in four, with full weekends, to partial, hybrid, and full shift patterns, I am in a reasonable position to comment on what I think makes a liveable on-call rota.I was under the impression that the European Working Time Directive was set out to improve the health and safety of workers, make working conditions better, but also make life away from work better because doctors would be less tired.The directive scores a "no" against all of these.I find myself more tired at work and at home, less enthusiastic, and less motivated by what is becoming a regular chore.Instead of being on call once a week, I find myself doing an on-call shift two or three times a week (on average), being late home more often than not because fewer juniors are around, and spending less time with my young children.The "old" rota system of a 24 hour oncall, with at least six on a rota, made on-call shifts less frequent, more tolerable, and even enjoyable.It also left plenty of time for training, and so long as there were six or more on rota, it made the annual leave far more flexible and workable.Anaesthetists rarely complained, certainly compared with other specialties' rotas, and everyone knew that however busy, you were always going to go home to a full day off in the morning.Why not listen to those doing the rota, and affected family members, and respect within reason what the workers want to work.
Electrophysiological Correlates of Contractile Change in Mammalian and Amphibian Myocardium
Authors: R. E. Edmands, K. Greenspan, C. Fisch
Journal: Cardiovascular Research (1968)

Studies of canine and frog myocardium disclose a consistent inverse relation between interval-dependent contractile alterations and the duration of phase 2 of the concomitant action potentials (AP). This is true despite the differing temporal patterns of contractile change in the two species. A relation of both the inotropic state and AP configuration to K+ flux is suggested.
Jaundice after Therapy with Chlordiazepoxide Hydrochloride
Authors: Americo Abbruzzese, John Swanson
Journal: New England Journal of Medicine (1965)

THE toxic effects of a number of drugs on liver-cell function have been recognized for many years. The magnitude of the problem of drug-induced jaundice is impossible to assess accurately since many cases go unrecognized or unreported. However, a recent review has shown that the number of drugs causing liver dysfunction has nearly doubled since 1959.1,2 Chlordiazepoxide hydrochloride (Librium), a psychotherapeutic agent, was introduced in 1960. One year later, a relation between this drug and hepatic injury was suggested by Cacioppo and Merlis.3 Hollister et al.4 reported elevated serum glutamic oxalacetic transaminase (SGOT) activity in 4 of 36 patients receiving . . .
Higher adiposity in infancy associated with recurrent wheeze in a prospective cohort of children
Authors: Elsie M. Taveras, Sheryl L. Rifas-Shiman, Carlos A. Camargo, Diane R. Gold, Augusto A. Litonjua, Emily Oken, Scott T. Weiss, Matthew W. Gillman
Journal: Journal of Allergy and Clinical Immunology (2008)
The problem of general anaesthesia in patients with chronic respiratory disease.
Authors: J A Thornton
Journal: Thorax (1969)

<h3>BACKGROUND AND PURPOSE:</h3> Basilar artery occlusion remains one of the most devastating subtypes of ischemic stroke. The prognosis is poor if early recanalization is not achieved. The purpose of this study was to evaluate the safety and technical feasibility of self-expanding retrievable stents in the endovascular treatment of acute basilar artery occlusion. <h3>MATERIALS AND METHODS:</h3> Twenty-four patients with acute basilar artery occlusion were treated with Solitaire FR or Revive SE devices between December 2009 and May 2012. Additional treatment included intravenous and/or intra-arterial thrombolysis (21/24) and percutaneous transluminal angioplasty/permanent stent placement (7/24). Recanalization was assessed by means of the TICI score. Clinical outcome was determined at discharge (NIHSS), and at 3 months (mRS). <h3>RESULTS:</h3> Median NIHSS score on admission was 24; median duration of symptoms was 254 minutes. Successful recanalization (TICI 2b +3) by thrombectomy only was achieved in 18 patients (75%). Intracranial stent deployment after thrombectomy caused by underlying atherosclerotic stenosis was performed in 7 patients. If these patients with intracranial stent placement are included, successful recanalization was achieved in 21 of 24 patients (87.5%). NIHSS improvement ≥10 points was reached in 54% of patients (<i>n</i> = 13/24). Mortality during the first 3 months was 29% (7/24). After 3 months, 8 patients (33%) had a favorable clinical outcome (mRS 0–2). <h3>CONCLUSIONS:</h3> In our series, application of self-expanding retrievable stents in acute basilar artery occlusion resulted in a high recanalization rate without procedural complications and good clinical outcome in one-third of patients.
Regulation of binding proteins for insulin-like growth factors (IGF) in humans. Increased expression of IGF binding protein 2 during IGF I treatment of healthy adults and in patients with extrapancreatic tumor hypoglycemia.
Authors: J Zapf, C Schmid, H P Guler, M Waldvogel, C Hauri, E Futo, P Hossenlopp, M Binoux, E R Froesch
Journal: Journal of Clinical Investigation (1990)

Insulin-like growth factors (IGFs) in blood form two complexes with specific binding proteins (BPs): a large, growth hormone (GH)-dependent complex with restricted capillary permeability, and a smaller complex, inversely related to GH, with high turnover of its IGF pool and free capillary permeability. The distribution of BPs and of IGFs I and II between these complexes was studied in sera from healthy adults treated with IGF I or/and GH and from patients with extrapancreatic tumor hypoglycemia. Like GH, IGF I administration raises IGF I and two glycosylation variants of IGFBP-3 in the large complex, but unlike GH drastically reduces IGF II. During IGF I infusion, IGFBP-3 appears in the small complex whose IGFBP-2 and IGF I increase three- to fivefold and fivefold, respectively. GH treatment, associated with elevated insulin levels, suppresses IGFBP-2 and inhibits its increase owing to infused IGF I. The small complex of tumor sera contains increased amounts of IGFBP-2 and -3, and two- to threefold elevated IGF II. Conclusions: low GH and/or insulin during IGF I infusion and in extrapancreatic tumor hypoglycemia enhance expression of IGFBP-2 and favor partition of IGFBP-3 into the small complex. Free capillary passage and high turnover of its increased IGF I or II pools may contribute to compensate for suppressed insulin secretion during IGF I infusion or to development of tumor hypoglycemia.
Embryologie: Ein Lehrbuch auf allgemein biologischer Grundlage
Authors: Charles W. Bodemer
Journal: JAMA (1966)

<b>Developmental Anatomy: A Textbook and Laboratory Manual of Embryology,</b>by Leslie Brainerd Arey, ed 7; 695 pp, 638 illus, $10, Philadelphia: W. B. Saunders Co., 1965. This edition of Starck's<i>Embryologie</i>aims at incorporating new knowledge generated in the decade since its first publication. The book retains its primary emphasis on descriptive embryology, which is established within a framework of traditional comparative embryology, and related to data and concepts of modern developmental biology. The text presents the full range of vertebrate development, beginning with the germ cells and extending through the formation of special organs in animals ranging from Branchiostomes to the human. Consistently, each subject is discussed in thorough detail, with careful attention to the relevant phylogenetic relations and appropriate experimental data. The author's splendid grasp of the myriad facets of comparative embryology appears in the many admirable syntheses throughout the work. The book abounds in details, but without
Success and Failure in the NARA Addiction Program
Authors: CHARLES L. BOWDEN, BERNARD J. LANGENAUER
Journal: American Journal of Psychiatry (1972)

The authors compared characteristics of 14 successful and 49 unsuccessful addict patients of the Narcotic Addict Rehabilitation Act treatment program. The most significant differences that they found were that successful patients were more likely to have graduated from high school, began using opioids later in their lives, more frequently began work during their first month in aftercare, and had much better work records over the initial six-month period.