tbuckley/cabot-search huggingface dataset:
Prevalence of Cardiovascular Autonomic Dysfunction Assessed by Spectral Analysis and Standard Tests of Heart-Rate Variation in Newly Diagnosed IDDM Patients
Authors: Dan Ziegler, Karsten Dannehl, Hansjürg Mühlen, Manfred Spüler, F Arnold Gries
Journal: Diabetes Care (1992)

Objective To determine the prevalence of cardiovascular autonomic nerve dysfunction in patients with newly diagnosed insulin-dependent diabetes mellitus (IDDM) compared with healthy nondiabetic subjects. Research Design and Methods A battery of cardiovascular reflex tests was performed in 130 newly diagnosed IDDM patients aged 12–40 yr at mean blood glucose levels of 7.2 mM after insulin had been administered for 3–39 days. Age-dependent lower limits of normal of these tests were defined at the 2.3 percentile in 120 nondiabetic subjects. Tests of heart-rate variation (HRV) included the coefficient of variation (C.V.) and the low-frequency (LF), midfrequency (MF), and high-frequency (HF) bands of spectral analysis at rest, HRV during deep breathing (C.V., expiratory-inspiratory ratio, and mean circular resultant), Valsalva ratio, and maximum/minimum 30:15 ratio. In addition, spectral analysis on standing, the change in systolic blood pressure to standing, and diastolic blood pressure response to sustained handgrip were determined in 50 patients. Results A significantly higher percentage of abnormal test responses in the diabetic group compared with the control group was noted for power spectrum in the LF band (7.3 vs. 0.8%, P &amp;lt; 0.05) and MF band (10.6 vs. 0%, P &amp;lt; 0.001) at rest and HF band on standing (10.0 vs. 0.9%, P &amp;lt; 0.05), maximum/minimum 30:15 ratio (25.4 vs. 5.0%, P &amp;lt; 0.001), and Valsalva ratio (17.5 vs. 4.2%, P &amp;lt; 0.001). There were no significant differences between both groups in regard to the remaining parameters. Ten (7.7%) diabetic patients but none of the nondiabetic subjects had cardiovascular autonomic neuropathy defined by the strict criterion of abnormal results in more than three of six tests (P &amp;lt; 0.001). In addition, 12 (9.2%) patients but only 2 (1.7%) control subjects had abnormal results in two of six tests (P &amp;lt; 0.01). Conclusions Cardiovascular autonomic nerve dysfunction is relatively common in newly diagnosed IDDM patients after correction of the initial metabolic imbalance. A combination of tests based on spectral and conventional analysis of HRV appears suitable for detection of early abnormalities in autonomic function in diabetes.
The Changes in the Intra-Arterial Pressure during Immersion of the Hand in Ice-Cold Water
Authors: JOHN O. GODDEN, GRACE M. ROTH, EDGAR A. HINES, Jerry F. Schlegel
Journal: Circulation (1955)

The response of the intra-arterial pressure to the cold immersion stimulus was studied in 42 healthy young adults, continuous direct (arterial-pressure) recording being used. The average systolic elevation was 22.6 mm. Hg and the average diastolic elevation was 16.3 mm. Hg. The difference between direct and indirect methods of measuring blood pressure was studied in 351 simultaneous determinations in 35 of these young adults. The direct systolic pressure averaged 9.7 mm. Hg higher and the diastolic pressure was 7.3 mm. Hg lower than the indirect measurement.
A Comparison of Meta-analytic Results Using Literature vs Individual Patient Data
Authors: Gary T. Jeng
Journal: JAMA (1995)

To compare the meta-analytic results from published literature vs those obtained from pooling original patient data.Individual patient data from 15 completed or ongoing trials on paternal white blood cell immunization as treatment for recurrent miscarriage were obtained through the American Society for Reproductive Immunology.Only randomized controlled trials were selected. Within these eight selected trials, 202 patients were from four published studies, 43 were added by the same investigators after publication, and 140 were from four unpublished trials.Individual patient data were collected using a standardized form and double data entry.Using the fixed treatment effect model, we found that the effect of immunization, denoted as the relative live-birth ratio (RR), was greater by pooling summary data from published articles (RR, 1.29; 95% confidence interval [CI], 1.03 to 1.60) than by pooling all individual patient data from the same investigators (RR, 1.17; 95% CI, 0.97 to 1.37) or when individual patient data were pooled from four unpublished trials (RR, 1.01; 95% CI, 0.74 to 1.28). A similar diminishing treatment effect for the same comparisons was observed using the random treatment effect model (RR, 1.38; 95% CI, 0.89 to 1.87 using published summary data; RR, 1.18; 95% CI, 0.98 to 1.42 using individual patient data; RR, 1.01; 95% CI, 0.74 to 1.28 using unpublished trials).Meta-analytic results may differ depending on the use of various data sources: whether the source was from summary statistics in the literature, from individual patient data provided by trialists, or from unpublished trials.
THE LANCET DEFENCE OF ONE OF DR. O'CONNOR'S SLANDERS
Authors: R. Druitt
Journal: BMJ (1854)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following THE LANCET DEFENCE OF ONE OF DR. O'CONNOR'S SLANDERS Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia
Authors: Makoto Ishihara, Natsumi Araya, Tomoo Sato, Ayako Tatsuguchi, Naomi Saichi, Atae Utsunomiya, Yusuke Nakamura, Hidewaki Nakagawa, Yoshihisa Yamano, Koji Ueda
Journal: Blood (2013)
Treatment of Pavor Nocturnus and Somnambulism in Children
Authors: RICHARD B. PESIKOFF, PARMA C. DAVIS
Journal: American Journal of Psychiatry (1971)

The authors studied seven children with either pavor nocturnus or somnambulism, or both, in an attempt to find a method of treating these sleep disorders. Each child received imipramine orally at bedtime for a minimum of eight weeks. In all seven patients a complete cessation of symptoms resulted. Although the drug seems to be an effective treatment for these disorders, its mechanism of action is not yet known.
Abstract 701: TUMOR lymphocyte infiltration, expression of CD4, CD8, FOXP3, CD34 molecules and their relationship with tumor evolution after primary treatment in breast cancer patients
Authors: María J. Rico, Viviana R. Rozados, Cintia Herrera, Carlos M. Alasino, Laura M. Vargas Roig, Francisco E. Gago, Olga Tello, Ana L. Nocito, Eduardo Roggero, Olga G. Scharovsky
Journal: Cancer Research (2012)

Abstract Considering that, approximately, only half of breast cancer patients respond to present therapies, a better knowledge of breast cancer biology, one of the most common neoplasms in women, will enable to design better therapeutic approaches. It has been proposed that different tumor characteristics like inflammatory infiltrate intensity, number of T regulatory (Tregs) cells and density of tumor vasculature could be useful to anticipate the response to therapy. Our aim was: a) to analyze the lymphocytic infiltrate and the expression of CD4, CD8, CD34 (endothelial marker) and Foxp3 (Treg marker) in primary tumors of breast cancer patients, and b) to relate them with clinical evolution (disease free: DF or relapsed: R) after 5 years from the primary treatment (surgery). There were analyzed archive samples of ductal mammary tumors (n=27), mostly in stages I and II. The expression of CD4 and CD8 in intra- and peri-tumoral lymphocytes was determined by immunohistochemistry (IHC) and confirmed by confocal microcopy; also the expression of Foxp3 in lymphocytes and tumor cells and CD34 in endothelial cells was evaluated by IHC. The lymphocytic infiltrate was assessed in histological sections stained with hematoxylin-eosin. The quantification was done in 20 high magnification fields and a score ranging from 0 (null) to 6 (high) was utilized. In DF patients (n=22) the intratumoral lymphocytic infiltrate (median [range]: 3 [0-6]) was more intense than that of R patients (n=5), (2 [0-2]), (P=0.05). For CD4, CD8, CD34 and Foxp3 molecules no differences between groups of patients were observed, being their expression highly variable: the score for CD34 varied from 1 to 6 and for the other three molecules from 0 to 6, in either group. In conclusion, the presence of an intense intratumoral lymphocytic infiltrate could be a prognostic marker of good response to treatment, at least in the first 5 years after surgery. These results warrant the study of higher number of tumor samples, since its confirmation could give support for its use in the clinical setting. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 701. doi:1538-7445.AM2012-701
A mismatch with dual process models of addiction rooted in psychology
Authors: Reinout W. Wiers, Remco Havermans, Roland Deutsch, Alan W. Stacy
Journal: Behavioral and Brain Sciences (2008)

Abstract The model of addiction proposed by Redish et al. shows a lack of fit with recent data and models in psychological studies of addiction. In these dual process models, relatively automatic appetitive processes are distinguished from explicit goal-directed expectancies and motives, whereas these are all grouped together in the planning system in the Redish et al. model. Implications are discussed.
"Saline Resistant" Metabolic Alkalosis, and Severe Potassium Depletion.
Authors: Serafino Garella
Journal: Annals of Internal Medicine (1969)

s1 May 1969"Saline Resistant" Metabolic Alkalosis, and Severe Potassium Depletion.Serafino Garella, M.D., Joseph A. Chazan, M.D., Jordan J. Cohen, M.D.Serafino Garella, M.D.Search for more papers by this author, Joseph A. Chazan, M.D.Search for more papers by this author, Jordan J. Cohen, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1101_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe common causes of metabolic alkalosis, diuretics, and loss of gastric acid produce both chlorine and potassium depletion, and both should be replaced during therapy. When potassium deficits are in the usual range (up to 450 mEq), however, it has been shown that the administration of sodium chloride without potassium results in chlorine retention by the kidney and repair of the acid-base abnormality; thus, moderate potassium depletion does not appear to be responsible for the alkalosis. Administered sodium chloride, however, does not result in chlorine retention by the kidney in patients with "saline-resistant" alkalosis. Such saline resistance is known to... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Serafino Garella, M.D.; Joseph A. Chazan, M.D.; Jordan J. Cohen, M.D.Affiliations: Providence, Rhode Island PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1101-1101KeywordsDiureticsKidneysPotassiumSodium chloride ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
Reported error rates are likely to be underestimation
Authors: B. D. Franklin, K. Taxis, N. Barber
Journal: BMJ (2009)

A total of 225 patients were treated for hyperthyroidism with 555 MBq (15 mCi) radioiodine to ablate the thyroid and induce early hypothyroidism. The efficacy of this treatment in eradicating hyperthyroidism and problems of follow up were assessed one to six years later from case records and questionnaires. Information was received from 197 out of 219 live patients (90%) and from 160 doctors concerning 207 patients (92%). Only three patients were not traced and six had died since treatment. The modal time to hypothyroidism was three months, and 64% of patients were hypothyroid at one year; 5.6% had failed to become euthyroid within one year. Ninety five per cent of patients had been seen by the doctor and 82% had had a thyroid test done within the past two years. Most doctors preferred patients to be returned to their care once thyroxine treatment was stabilised. An ablative dose of 131I is recommended as an effective means of treatment which has clear advantages over conventional methods. Good communications and effective follow up should ensure success.
If jogging is a joke, who should have the last laugh?
Authors: P I Middleton
Journal: British Journal of Sports Medicine (2000)

It was the end of my sabbatical in Canada, and I was strolling around Stanley Park, one of the many jewels of Vancouver British Columbia. I was just finishing a four month trip in Australia and Canada studying educational methods used to teach general practitioners. OK I'll come clean—I was having an “extended holiday with a purpose”. On this beautiful autumnal Sunday, the air was crisp and, as the sun sparkled on Burrard Inlet, the colours of the spruce, maple, and arbutus painted the lower slopes of the snow clad peaks across the bay. “No wonder this is one of the most popular places to live in our world” I thought.

Despite this idyll most of the people I saw that day looked ill at ease, in pain even. Why? I hear you ask. The answer is obvious: they were jogging! Why is an activity that is so blatantly uncomfortable so universally popular? At least it is good for them I thought.

Weeks later I was idly sharing these observations with a friend. He asked casually for another example of a bodily system that functions …
Dependence of human maximum vertical counter-movement jump height on activation sequence of the biarticular muscles
Authors: M Bračič, M Supej, Z Matjačić
Journal: British Journal of Sports Medicine (2011)

Background When executing vertical jumps a noticeable problem transpires in the efficient transfer of rotational energies of the trunk and the lower body segments into the largest possible vertical velocity. In the transfer of energy, the biarticular muscles rectus femoris (RF) and gastrocnemius (GAS) play an important (Bobbert &amp; Van Ingen Schenau, 19881; Gregoire et al ., 19842). Objective The hypothesis of the study were that athletes with greater maximum vertical counter movement jump height have better energy efficiency of two-legged jumps due to correct activation sequence of the biarticular muscles RF and GAS, which ensure a transfer of rotational kinetic energy between body segments following a proximal to distal principle. Setting and participants 12 male elite athletes (age: 22.41±3.39 years; height 177.58±6.86 cm, body mass 74.92±5.23 kg) performed two-leg counter movement jumps (CMJ). Methods Eight camcorders with a frequency of 200 Hz were used for the 3D kinematic measurements of CMJ. The ground reaction forces of jumps were measured unilaterally and bilaterally using two independent and synchronized force platforms. The maximal jump height of the centre of body's mass (HCM) was determined by the time integration (tfl) of the vertical force (F=Fz-mg) signal: HCM=tfl2•g•8–1. Electromyographical data of the time to peak EMG (TTPEMG) from biarticular RF and GAS in concentric phase of the jump were analyzed. Results The comparison between two groups showed that athletes with greater maximum vertical counter movement jump height (group_1: 64.10±5.08 cm vs group_2: 56.41±3.88 cm; p&lt;0.05) have different activation sequence of the biarticular RF and GAS (group_1; TTPEMG_RF=110.53±20.11 ms, TTPEMG_GAS=137.88±22.43 ms vs group_2; TTPEMG_RF=143.56 ±32.23 ms, TTPEMG_GAS=84.81±25.67 ms; p&lt;0.05) which indirectly implicate that the transfer of rotational kinetic energy between body segments follows a proximal to distal principle. Conclusions It is concluded that correct activation sequence of the RF and GAS is essential in the execution of vertical counter movement jump.
TRENDS IN UPTAKE AND IN-HOSPITAL OUTCOMES WITH 2ND GENERATION DRUG ELUTING STENTS BETWEEN MEN AND WOMEN UNDERGOING PERCUTANEOUS CORONARY INTERVENTION: RESULTS FROM THE CATHPCI REGISTRY
Authors: Usman Baber, Tracy Wang, Cindy Grines, Lisa McCoy, Paramita Chaudhuri, Patricia Best, Kimberly Skelding, Rebecca Ortega, Alaide Chieffo, Julinda Mehilli, James Tcheng, Roxana Mehran
Journal: Journal of the American College of Cardiology (2014)
Methionine Deprivation Induces a Targetable Vulnerability in Triple-Negative Breast Cancer Cells by Enhancing TRAIL Receptor-2 Expression
Authors: Elena Strekalova, Dmitry Malin, David M. Good, Vincent L. Cryns
Journal: Clinical Cancer Research (2015)

Many neoplasms are vulnerable to methionine deficiency by mechanisms that are poorly understood. Because gene profiling studies have revealed that methionine depletion increases TNF-related apoptosis-inducing ligand receptor-2 (TRAIL-R2) mRNA, we postulated that methionine stress sensitizes breast cancer cells to proapoptotic TRAIL-R2 agonists.Human triple (ER/PR/HER2)-negative breast carcinoma cell lines were cultured in control or methionine-free media. The effects of methionine depletion on TRAIL receptor expression and sensitivity to chemotherapy or a humanized agonistic TRAIL-R2 monoclonal antibody (lexatumumab) were determined. The melanoma-associated antigen MAGED2 was silenced to delineate its functional role in sensitizing TNBC cells to methionine stress. An orthotopic TNBC model was utilized to evaluate the effects of dietary methionine deficiency, lexatumumab, or the combination.Methionine depletion sensitized TNBC cells to lexatumumab-induced caspase activation and apoptosis by increasing TRAIL-R2 mRNA and cell surface expression. MCF-10A cells transformed by oncogenic H-Ras, but not untransformed cells, and matrix-detached TNBC cells were highly sensitive to the combination of lexatumumab and methionine depletion. Proteomics analyses revealed that MAGED2, which has been reported to reduce TRAIL-R2 expression, was suppressed by methionine stress. Silencing MAGED2 recapitulated features of methionine deprivation, including enhanced mRNA and cell surface expression of TRAIL receptors and increased sensitivity to TRAIL receptor agonists. Dietary methionine deprivation enhanced the antitumor effects of lexatumumab in an orthotopic metastatic TNBC model.Methionine depletion exposes a targetable defect in TNBC cells by increasing TRAIL-R2 expression. Our findings provide the foundation for a clinical trial combining dietary methionine restriction and TRAIL-R2 agonists. Clin Cancer Res; 21(12); 2780-91. ©2015 AACR.
Myosin adenosinetriphosphatase activity and light chain subunit composition of human right and left ventricle
Authors: K. M PRICE, W. A LITTLER, P. CUMMINS
Journal: Cardiovascular Research (1980)

Journal Article Myosin adenosinetriphosphatase activity and light chain subunit composition of human right and left ventricle Get access KAREN M PRICE, KAREN M PRICE From the Department of Cardiovascular Medicine, University of Birmingham, and Queen Elizabeth Hospital, Birmingham, England Search for other works by this author on: Oxford Academic PubMed Google Scholar WILLIAM A LITTLER, WILLIAM A LITTLER From the Department of Cardiovascular Medicine, University of Birmingham, and Queen Elizabeth Hospital, Birmingham, England Search for other works by this author on: Oxford Academic PubMed Google Scholar PETER CUMMINS PETER CUMMINS * From the Department of Cardiovascular Medicine, University of Birmingham, and Queen Elizabeth Hospital, Birmingham, England *Address for reprints: Dr P Cummins, Department of Cardiovascular Medicine, Clinical Research Block, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, England. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 14, Issue 10, October 1980, Pages 555–560, https://doi.org/10.1093/cvr/14.10.555 Published: 01 October 1980
Isoenzymes in Clinical Diagnosis
Authors: THEODORE L. GOODFRIEND, NATHAN O. KAPLAN
Journal: Circulation (1965)

The recent literature attests to the increasing number of enzymes for which isoenzymes or subunit structure or both are known. Several symposia and reviews have been published within the past few years. 46-50 Some enzyme activities for which isoenzymes have been described are listed in table 4. Only those found in mammals are included. They are ranked in rough order of apparent usefulness in clinical diagnosis, with the enzymes displaying tissue localization and catalytic differences listed first. Also, the number of molecular forms and the presence or absence of known subunit structure is indicated. Clinical studies have been made using several of the isoenzymes listed in table 4, and references denoting these studies are marked with an asterisk. Data presented in the table indicate that valuable clinical information might derive from study of other isoenzymes, notably phosphofructokinase, for which tissue differences and adaptable catalytic differences exist. The guidelines set forth in this review can be used for investigating still other isoenzymes, such as those studied in lower forms. 79-85 In brief, the study of isoenzymes, like the study of enzymes and other organ-specific chemicals, presents an opportunity for great specificity and accuracy in localizing and following disease processes.
Ultrastructure of high altitude pulmonary oedema
Authors: D. Heath, H. Moosavi, P. Smith
Journal: Thorax (1973)

<b>Heath, D., Moosavi, H., and Smith, P. (1973).</b><i>Thorax</i>, <b>28</b>, 694-700. <b>Ultrastructure of high altitude pulmonary oedema.</b> When rats are exposed for 12 hours to simulated high altitude corresponding to the summit of Mount Everest, they develop ultrastructural changes in the lungs. These consist of the formation and protrusion of multiple endothelial vesicles into the pulmonary capillaries. It seems likely that they are associated with the development of high altitude pulmonary oedema.
Effect of cyclandelate on mental function and cerebral blood flow in elderly patients.
Authors: J. A. Ball, A. R. Taylor
Journal: BMJ (1967)

There is no demonstrable impairment in the ability of the cerebral blood vessels of elderly subjects to dilate in response to physiological stimuli (Lassen, 1959), but there is general agreement that chemical agents are relatively ineffective in producing such dilatation. Recently, however, reports have appeared that dilatation of cerebral vessels has occurred in response to cyclandelate (Eichhorn, 1965 ; Kuhn, 1965), and there is some uncontrolled evidence that cyclandelate produces an improvement in mental function in elderly patients (Drift, 1961 ; Ravina, 1963 ; Ward, 1964). As the production of a substantial improvement in mental function in elderly patients would be of inestimable value, a controlled trial of cyclandelate has been made so that its effect on mental function and cerebral circulation in elderly patients could be investigated.
He died "peacefully" at home
Authors: D. Veale
Journal: BMJ (2003)

I like collecting euphemisms. I found a new one when my father, a retired general practitioner, died “peacefully” at home. That is what the announcements say in the newspapers, and that is what my relatives are telling everyone.

It was a perfectly routine death, in which my 93 year old father had cancer of the prostrate. The cancer had …