tbuckley/cabot-search huggingface dataset:
Lysozymuria as an Indication of Renal Tubular Damage.
Authors: Darwin J. Prockop
Journal: Annals of Internal Medicine (1964)

s1 February 1964Lysozymuria as an Indication of Renal Tubular Damage.Darwin J. Prockop, M.D., Warren Davidson, M.D.Darwin J. Prockop, M.D.Search for more papers by this author, Warren Davidson, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-338_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe urinary excretion of the enzyme lysozyme has been observed previously in some patients with renal disease, but the significance of lysozymuria has not been established. In the present study, less than 4 µg/ml of urinary lysozyme actively (ULA) were found in 150 normal adults and patients without renal disease. By contrast, 37 of 59 patients with azotemia (blood urea nitrogen (BUN) > 20 mg/100 ml) excreted 5 to 120 µg/ml of ULA. Only 2 patients with BUN levels more than 30 mg/100 ml showed significant lysozymuria; both patients had nephrotic syndrome and died with severe uremia within 3 months.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Darwin J. Prockop, M.D.; Warren Davidson, M.D.Affiliations: Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1964Volume 60, Issue 2_Part_1Page: 338-338KeywordsBlood urea nitrogenEnzymesExcretionLysozymeRenal diseases ePublished: 1 December 2008 Issue Published: 1 February 1964 PDF downloadLoading ...
Abstract 1327: Targeting the RB-pathway in sarcoma: Utility of CDK4/6 inhibitors
Authors: Ashleigh M. Francis, Jason P. Carey, Angela Alexander, Khandan Keyomarsi, Kelly K. Hunt
Journal: Cancer Research (2014)

Abstract Background: Sarcomas are rare neoplasms of mesenchymal origin. Survival rates have not improved with standard chemotherapy; however, molecular insights have posed new drug targets. Aberrations in the RB-pathway, including loss of RB, CDK4 and cyclin D1 overexpression and p16 loss, have been identified in sarcomas. PD 03322991 (PD) is a second generation CDK4/6 inhibitor with the potential to reactivate the RB-pathway and suppress cell cycle progression. We evaluated the efficacy of PD in a panel of sarcoma cell lines. Methods: Sarcoma cell lines (HT-1080, SK-LMS-1 and SaOS-2) were evaluated for RB-pathway alterations using western blot. Cells were treated with PD for 1, 2, 4, 6 and 8 days to determine IC50 values by MTT assay. Following the same treatment protocol at IC50 concentrations of PD, cells were harvested for cell cycle analysis, western blot and annexin cell death assay. Results: HT-1080 and SK-LMS-1 were RB-positive with high expression of phospho-RB; SaOS-2 was RB-negative. CDK4/6 were uniformly expressed. HT-1080 and SK-LMS-1 had p16 loss while SaOS-2 overexpressed cyclin D1. PD was effective in all cell lines. Increasing treatment duration led to reduction of IC50 values. PD caused marked G1 arrest as early as day 1 in RB-positive HT-1080 (86.2% vs 74.2% [vehicle]) and SK-LMS-1 (91.4% vs 67.8% [vehicle]) but not RB-negative SaOS-2 (52.9-59.4% vs 57.0% [vehicle]). Annexin assay demonstrated minimal apoptosis with PD (HT-1080: 1.4-3.0% vs 41.2% [control], SK-LMS-1: 0.6-12.0% vs 23.4% [control], SaOS-2: 3.6-7.3% vs 78.7% [control]). Conclusions: PD appears to have a cytostatic rather than cytotoxic effect in sarcoma. RB-negativity does not preclude PD efficacy but may require higher IC50 values. In RB-negative sarcomas, PD does not cause cell cycle arrest suggesting an alternate mechanism from reactivation of the RB-pathway is present. PD may serve as a potential therapy for sarcoma and should be studied in combination with other targeted therapies that can take advantage of its ability to cause G1 arrest. Cell LinePD 991 IC50 Concentration (uM)Day 1Day 2Day 4Day 6Day 8HT-1080∼∼4.31.51.1SK-LMS-1∼∼∼2.41.2SaOS-2∼15.510.17.06.0 Citation Format: Ashleigh M. Francis, Jason P. Carey, Angela Alexander, Khandan Keyomarsi, Kelly K. Hunt. Targeting the RB-pathway in sarcoma: Utility of CDK4/6 inhibitors. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1327. doi:10.1158/1538-7445.AM2014-1327
High-salt diet elevates baroreceptor pressure thresholds in normal and Dahl rats.
Authors: M C Andresen
Journal: Circulation Research (1989)

Dahl Salt Sensitive (DS) rats rapidly develop high blood pressure when exposed to a high-salt diet. Recent studies suggest that DS rats have poorly functioning baroreceptor afferents and baroreflexes even when salt intake is restricted. This study examines baroreceptor pressure- and mechano-transduction in DS, Dahl Resistant (DR), and Sprague-Dawley (SD) rats during low- and high-salt conditions. Single unit, regularly discharging baroreceptors were studied using an in vitro aortic arch-aortic nerve preparation. Pressure thresholds and suprathreshold pressure sensitivities were determined from responses to slow ramps of pressure. Pressure-diameter relations measured in each rat were used to transform pressure threshold and pressure sensitivity values to their mechanical equivalents in terms of aortic wall strain. A total of 407 unit baroreceptors were studied from 49 rats. Tail systolic blood pressures were significantly higher only in DS during high salt. Pressure threshold was similar for all groups on low salt. Exposure to a high-salt diet increased the mean pressure threshold for all three groups. Pressure threshold for high-salt diet was highest in DS and lowest in DR. Pressure sensitivities were lowest in DS and highest in DR on low salt. High salt had no significant effect on pressure sensitivity. The differences in threshold apparent when expressed in terms of pressure were eliminated by conversion to their mechanical equivalents (strain threshold and strain sensitivity). The results suggest that baroreceptors in the two Dahl rat strains represent two extremes from normal baroreceptor function. DS tend to be less pressure responsive than normal (SD), and DR tend to be somewhat more responsive to pressure.(ABSTRACT TRUNCATED AT 250 WORDS)
Precautions in Testing for Carcinoembryonic Antigen
Authors: William C. Dierksheide
Journal: JAMA (1981)

To the Editor.—  Certain precautions must be followed when testing for carcinoembryonic antigen (CEA) in patients with cancer. Tests for CEA are to be used only for treatment of cancer patients and assessing prognosis. They are not intended for screening or diagnosis.  On Oct 15, 1980, the Bureau of Medical Devices of the Food and Drug Administration issued approval to Abbott Laboratories of North Chicago, Ill, to market a solid-phase radioimmunoassay (RIA) and a solid-phase enzyme immunoassay (EIA), both for the measurement of CEA. The only other test on the market for determining CEA is a competitive binding RIA test from Hoffmann-La Roche, Inc, Nutley, NJ, who received approval in December 1973. A box warning is being included in the labeling of the package insert as follows:  The concentration of CEA in a given specimen determined with assays from different manufacturers can vary due to differences in assay methods and
Subcellular targets of cadmium nephrotoxicity: cadmium binding to renal membrane proteins in animals with or without protective metallothionein synthesis.
Authors: G F Nordberg, T Jin, M Nordberg
Journal: Environmental Health Perspectives (1994)

Nephrotoxic effects of cadmium exposure are well established in humans and experimental animals. An early manifestation of such toxicity is calciuria a few hours after injection of CdMT in rats. Protection against calciuria and other adverse effects such as proteinuria (occurring later) is offered by pretreatment with Cd, which effectively induces metallothionein synthesis. In the present experiment, one group of animals was given pretreatment with CdCl2 to induce metallothionein synthesis. The comparison group was left without pretreatment. The distribution of Cd from a normally nephrotoxic dose of 109CdMT was studied by gel chromatography in subcellular fractions of kidney cortex in both groups. In the pretreated animals, 109Cd in the plasma membrane and microsome fractions of renal cortical cells was mainly bound to metallothionein and other low molecular weight proteins at 4 hr. In nonpretreated animals the major part of 109Cd was bound to high molecular weight proteins. These findings indicate that membrane proteins may be important targets for Cd when inducing nephrotoxicity and that sequestering of Cd by metallothionein (and other low molecular weight proteins) may be a mechanism of protection.
98 Key role of phosphatidylinositol 3-kinase-mediated signals in hepatic preconditioning
Authors: R. Carini, M.G. De Cesaris, R. Splendore, G. Baldanzi, M.P. Nitti, E. Alchera, N. Filigheddu, C. Domenicotti, M.A. Pronzato, A. Graziani, E. Albano
Journal: Journal of Hepatology (2004)
A forty-year review of bacterial endocarditis in infancy and childhood.
Authors: D H Johnson, A Rosenthal, A S Nadas
Journal: Circulation (1975)

A retrospective review of 149 episodes of bacterial endocarditis (BE) in 141 patients under 25 years of age, at The Children's Hospital Medical Center from 1933 through June of 1972, demonstrates increasing survival and a distinct change in the frequency of underlying congenital heart disease and rheumatic heart disease (RHD). Certain forms of congenital heart disease such as tetralogy of Fallot, small ventricular septal defect, and aortic stenosis are at particular risk for BE. Following BE, patients with ventricular septal defect and tetralogy of Fallot have less morbidity and higher survival rates than children with aortic outflow lesions. over the entire time period, alpha Streptococcus is the most common pathogen and Staphylococcus aureus, second most frequent organism. Surgical correction in patients with congenital heart disease may offer the best form of prevention.
Reference range thyroid-stimulating hormone is associated with physical activity energy expenditure in overweight and obese postmenopausal women: a Montreal-Ottawa New Emerging Team Study
Authors: Geneviève Rondeau, Nicole Rutamucero, Virginie Messier, Lacramioara Burlacu, Denis Prud'homme, Hortensia Mircescu, Rémi Rabasa-Lhoret
Journal: Metabolism (2010)
Heritable Diseases of Collagen
Authors: Darwin J. Prockop, Kari I. Kivirikko
Journal: New England Journal of Medicine (1984)

FOR several decades it has been apparent that many diseases directly or indirectly involve collagen, the tough fibrous material that is the most abundant protein in the body and the major constituent of skin, tendons, ligaments, demineralized bone, and most blood vessels. The first definitive evidence for the involvement of collagen in diseases has come from studies on genetic disorders. It is now possible to group highly diverse genetic diseases around a core of information about the biochemistry and molecular biology of collagen. The consequences of this new information, however, extend beyond the field of rare genetic diseases. It is . . .
Temozolomide in Combination With Docetaxel in Patients With Advanced Melanoma: A Phase II Study of the Hellenic Cooperative Oncology Group
Authors: D. Bafaloukos
Journal: Journal of Clinical Oncology (2002)

PURPOSE: Temozolomide is a novel oral alkylating agent that is effective against melanoma. Moreover, temozolomide readily crosses the blood-brain barrier and may consequently be effective in patients with brain metastases. This phase II study was performed to assess the efficacy and safety of the combination regimen of temozolomide and docetaxel in patients with advanced metastatic melanoma. PATIENTS AND METHODS: Sixty-five patients with metastatic melanoma were enrolled. Treatment consisted of intravenous docetaxel (80 mg/m2) on day 1 and oral temozolomide (150 mg/m2) on days 1 to 5, every 4 weeks, for a maximum of six cycles. RESULTS: Sixty-two patients were eligible for the efficacy and safety analysis. Seventeen patients (27%) achieved an objective response, including five complete (8%) and 12 partial responses (19%). Median response duration was 9.5 months. Among responders, median time to progression (TTP) was 11.2 months and median overall survival (OS) was 16 months. For all treated patients, the median TTP was 4 months and median OS was 11 months. Three (38%) of eight patients who presented with brain metastases had a partial response for 5, 6, and 12 months. Of 52 patients who did not have brain involvement at presentation, only four (8%) developed brain metastases at a median follow-up of 14 months. Myelosuppression was the primary toxicity. CONCLUSION: The combination of temozolomide and docetaxel was effective and well tolerated as first-line treatment for patients with advanced metastatic melanoma and demonstrated encouraging antitumor activity against brain metastases.
Thrombin generation and procoagulant phospholipids in patients with essential thrombocythemia and reactive thrombocytosis
Authors: I. Mignon, F. Grand, F. Boyer, M. Hunault‐Berger, J.F. Hamel, L. Macchi
Journal: American Journal of Hematology (2013)

Thrombocytosis is a commonly encountered clinical scenario and can be either a secondary process (reactive thrombocytosis), or due to clonal disorder (i.e., essential thrombocythemia). This distinction is important as it carries implications for evaluation, prognosis and treatment. In this study we compared procoagulant potential in essential thrombocythemia and reactive thrombocytosis by measuring the thrombin generation and the level of circulating procoagulant phospholipids with functional tests. Twenty nine patients with essential thrombocythemia and 24 with reactive thrombocytosis were studied. Thrombin generation was determined by calibrated automated thrombography. Procoagulant phospholipids were detected by a chronometric standardised method (STA-Procoag-PPL). Patients with reactive thrombocytosis had a longer lag time, higher endogenous thrombin potential, peak of thrombin generation and velocity index than patients with essential thrombocythemia. The level of circulating procoagulant phospholipids was increased in patients with essential thrombocythemia as observed with the procoagulant phospholipids assay. Each parameter was analysed using ROC curves. Highest areas under the curve (AUC) were found for lag time and procoagulant phospholipids ratio (0.817 and 0.853, respectively), associated with high negative predictive value for ET (92.3% and 80%, respectively). In conclusion, patients with essential thrombocythemia and reactive thrombocytosis displayed significant differences in terms of thrombin generation and levels of procoagulant phospholipids. Among these parameters, lag time and procoagulant phospholipids ratio could help to differentiate between reactive thrombocytosis and essential thrombocythemia patients.
Tropomyosin in ascaris lumbricoides: A cross-reactive IgE binding protein?
Authors: L.K. Arruda, A.B.R. Santos, V.S.F. Sales, V.P.L. Ferriani, V.C.R. Dantas, C.E.B. Rodrigues, R.E. Esch, M.D. Chapman
Journal: Journal of Allergy and Clinical Immunology (2003)
882 SELECTIVE INDUCTION OF ADAPTIVE REGULATROY T-CELLS IN CHRONIC HEPATITIS C
Authors: B. Langhans, I. Braunschweiger, S. Arndt, W. Schulte, J. Satoguina, N. Vidovic, A. Hoerauf, J. Oldenburg, T. Sauerbruch, U. Spengler
Journal: Journal of Hepatology (2009)
UNUSUAL COMPLICATION FOLLOWING USUAL OPERATIVE PROCEDURE FOR VARICOSE VEINS
Authors: DAVID FISHER
Journal: JAMA (1925)

The diagnosis and operative procedure for the condition of varicose veins have become so standardized and simple that any mention of them is superfluous and uninteresting. It is because of this simple obvious diagnosis that now and then one encounters a complication, grave in its consequences, resulting from too hasty judgment in the handling of such a case. Within the last six weeks, two cases have been observed at our clinic, which emphasize and strike home vividly the extreme importance of a careful investigation in so self-evident a condition as varicose veins. <h3>Case 1.</h3> —A man, aged 32, was admitted to the surgical section of the National Military Hospital, being referred by two prominent physicians for resection of varicose veins of both legs. The history was essentially negative except for typhoid fever ten years before. Convalescence from the typhoid was complicated by pains in both thighs, which disappeared in about
Textbook of Pediatric Emergency Medicine
Authors: Suzanne Dooley-Hash
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Harveian Oration: Delivered before the Royal College of Physicians of London on St. Luke's Day, 1916
Authors: T. Barlow
Journal: BMJ (1916)

Gouston, one of Harvey's youiiger contemporaries1 who founded the lectureslhip which bears his name; Sir-Tlieodore de Mayerne, anotlher of Harvey's contemporaries; -Dr.Baldwin Hamiiey Junior, also a con- temporary of 'Harvey, a imunificent benefactor of the College, wlso presented to it the buildings in Amnen Court, and contributed to the rebuilding in Warwick Lane after the fire in 1666; the Marquis of Dorchiester, an lionot-ary Fellow, a studenit of physic and anatomy, who lhad probably gained Harvey's regard in Oxiord; and Dr. Croone, one of the original Fellows of the Royal Society, to whom the College owed -many valuable endowments.Finally he announced th at tlhe offer of Mrs. Eliza Streatfeild, made last June upon tle advice of Sir Jolhn Tweedy to the two Royal Colleg'.s
LOCAL ANAESTHESIA FOR TONSILLECTOMY
Authors: J. W. Costello
Journal: BMJ (1932)

OEDEMA IN THE NEWBORN TMEBItJITSAL 839 intertrigo, extensive oedema, and the urine of a haemorrhagic nephritis, typical glomerulo-nephritis being found post mortem.The other twin had oedema, but the urine was normal; there was complete recovery.None of my cases quoted above ever had albuminuria, and in one child (case not recorded) that died the kidneys were
Analysis of the existence of patterns related to counter-attack and fast attack in the Spanish League 2010/2011 season
Authors: A Barbosa, N Martins, J Leitão, J Campaniço, H Sarmento
Journal: British Journal of Sports Medicine (2011)

We investigated the regular behaviour patterns in Counter-Attack (CA) and Fast Attack (FA) in the Spanish League 2010/2011 season using the instrument validated by Sarmento et al ( Medicina (Kaunas) 2010; 46 ;401–7). This instrument consists in a specific notational system to study the offensive process and its variables, based on previous procedures and an exploratory phase of the study, in which we observed video images of several offensive sequences in nine games of Spanish League. To verify the occurrence of patterns, we used the software THEME 5.0, which is a professional system for detecting and analysing hidden patterns in behaviour, by performing intensive structural analysis of behavioural data. It detects complex repeated patterns that otherwise remain hidden. For the detection of the patterns, we only considered the ones repeating three times. We detected seven competed t-patterns, referring to the whole process, from recovering possession of the ball until completing the offensive process (OP) successfully. In the CA, we verified the existence of two patterns, one of which ended in goal. In the FA, we verified the existence of five patterns. Four patterns end with shot from frontal zone to goal. When analysing the patterns, we found that the area of recovery of possession is the midfield, with preponderance in the defensive midfield. In all detected patterns, the second action happens in another field zone with great impact on the opposite lateral corridor. After the ball gets to the offensive sector, there is a rapid and long change of the playing area and then the team tries to quickly end the OP. The attack ends or passes again through the corridor where it started. There is high incidence of the game in the side corridors. There was focus on strike from zone twelve, or from zone twelve to look for attack zone eleven and then terminate the action. This was a constant in all found patterns. In CA there's a pattern that ends with obtaining goal. Of the seven patterns found, both on CA and FA, the pattern that ends in a goal is the only action that ends with numerical superiority.
A Twin Study of Obesity-Reply
Authors: Terryl T. Foch
Journal: JAMA (1986)

<h3>In Reply.—</h3> We appreciate Dr Knight's pointing out the importance of context in interpreting the findings of our twin study of obesity. As he notes, concordance rates and heritability estimates are critically dependent on the environment in which they are measured, and different environments can give rise to different estimates of heritability. The role of environment is particularly important in assessing obesity, in which gene-environment interaction must surely be of great importance. And as he (and we) have noted, such interaction is not measured in twin studies. This limitation makes it important to assess the role of genetics in human obesity by methods that<i>can</i>assess gene-environment interaction. Adoption studies constitute one such method, and a recent adoption study<sup>1</sup>has confirmed the importance of genetic factors in human obesity. The data of our study do not, as Dr Knight says, support general conclusions regarding the relative roles of heredity