tbuckley/cabot-search huggingface dataset:
Bleomycin-induced flagellate dermatitis: a clinical and histopathological review
Authors: C.M. MOWAD, T.V. NGUYEN, R. ELENITSAS, J.J. LEYDEN
Journal: British Journal of Dermatology (1994)

We report a case of bleomycin‐induced flagellate dermatitis. Our patient developed pruritic linear lesions 4 days after her first dose of bleomycin. A closed patch test was performed, and was negative. However, on rechallenge, the linear eruption recurred in the previously involved sites, and in new sites, within 24 h. Flagellate dermatitis is a characteristic reaction to bleomycin use, but varying histological features and clinical presentations may be seen.
The effect of haematopoietic stem cell transplant on papules with 'pebbly' appearance in Hunter's syndrome
Authors: K. Ito, T. Ochiai, H. Suzuki, M. Chin, H. Shichino, H. Mugishima
Journal: British Journal of Dermatology (2004)

Background Hunter's syndrome is associated with several cutaneous findings. For instance, papules with 'pebbly' appearance are a specific marker for the disease. However, it remains uncertain whether they disappear after haematopoietic stem cell transplant (HSCT). Objectives To investigate the papules with 'pebbly' appearance before and after HSCT in infants with Hunter's syndrome, and to clarify the effect of HSCT on papules. Patients We observed five Japanese boys with Hunter's syndrome who had received HSCT at 4–11 years of age. Results The post‐HSCT physical examinations revealed that papules disappeared completely within 35 days after the transplant with progressive reduction of cutaneous tightness in all the patients. Histochemical findings showed that papules contained a large amount of hyaluronic acid in the extracellular materials of the dermis and sulphated acid mucopolysaccharides in dermal fibroblasts before HSCT. Conclusions These results suggest that papules with a 'pebbly' appearance fade away through the digestion of a large amount of hyaluronic acid in cutaneous tissues by normal tissue histiocytes or enzymes of donor origin at an early stage after HSCT.
The Syndrome of Bernheim as a Clinical Entity
Authors: HENRY I. RUSSEK, BURTON L. ZOHMAN
Journal: Circulation (1950)

Can the right ventricle become partially obliterated by a bulging and hypertrophied interventricular septum so as to produce the clinical picture of isolated right heart failure? If so, the syndrome of Bernheim must be accepted as a distinct clinico-pathologic entity. The authors have previously reported 3 cases of right ventricular stenosis which appeared to originate in this manner. More recently, this evidence has been challenged and theoretic objections have been raised as to the possible existence of the syndrome. The present report attempts to answer these contrary assertions and records another instance in which the syndrome was diagnosed clinically and confirmed at autopsy.
Role of interleukin 6 for differential responsiveness of naive and memory CD4+ T cells in CD2-mediated activation.
Authors: Y Kasahara, T Miyawaki, K Kato, H Kanegane, A Yachie, T Yokoi, N Taniguchi
Journal: The Journal of Experimental Medicine (1990)

The present study was undertaken to elucidate different requirements for CD2-mediated activation of naive (CD45RO-) and memory (CD45RO+) CD4+ T cells. A mitogenic combination of anti-CD2 (anti-T11(2) and anti-T11(3] mAbs could effectively induce the proliferation of memory CD4+ T cells even in the absence of monocytes. In marked contrast, naive CD4+ T cells did not disclose any proliferative responses to anti-CD2 mAbs, when monocytes were absent in culture. This differential responsiveness of naive and memory CD4+ T cells appeared to be related largely to a difference in IL-6-producing ability between both populations. IL-6 among monocyte-derived cytokines could correct unresponsiveness of naive CD4+ T cells to anti-CD2 stimulation. Unlike naive CD4+ T cells, memory CD4+ T cells produced IL-6 by themselves, with its mRNA being expressed on anti-CD2 stimulation. Anti-IL-6R mAb significantly inhibited proliferation of memory CD4+ T cells seen in the anti-CD2-stimulated cultures without monocytes, indicating the involvement of their own production of IL-6 in CD2-mediated activation. The results suggest an essential role of IL-6 for triggering of CD4+ T cells via the CD2 molecule.
Viral Nanoparticles: Probing the Endocytic Pathways of the Filamentous Bacteriophage in Live Cells Using Ratiometric pH Fluorescent Indicator (Adv. Healthcare Mater. 3/2015)
Authors: Ye Tian, Man Wu, Xiangxiang Liu, Zhi Liu, Quan Zhou, Zhongwei Niu, Yong Huang
Journal: Advanced Healthcare Materials (2015)

Endocytosis, the mechanism by which live cells internalize exogenous substances, is thought to be a key step in drug or gene delivery. The filamentous M13 bacteriophage has attracted extensive research interest as a biomaterial. On page 413, in the quest for biomedical applications, Z. Niu and co-workers investigate the internalization mechanism, the interaction with cell membrane, and the pH map of M13 in different cell lines.
[455] INHIBITION OF ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY (ADCC) DUE TO HCV CORE AA35-44 INDUCED STABILISATION OF HLA-E EXPRESSION
Authors: B. Kraemer, H.D. Nischalke, D. Schulte, T. Sauerbruch, U. Spengler, J. Natterman
Journal: Journal of Hepatology (2007)
Compensatory Hypertrophy of the Left Liver Lobe
Authors: MUSTAFA YILDIRIM, ERHAN VAROGLU, OMER ONBAS, SUAT EREN, MEHMET DERYA ONUK, HATICE USLU
Journal: Clinical Nuclear Medicine (2003)

YILDIRIM, MUSTAFA; VAROGLU, ERHAN; ONBAS, OMER; EREN, SUAT; DERYA ONUK, MEHMET; USLU, HATICE Author Information
Effect of Exercise on Coronary Tree Size in the Rat
Authors: JAMES A. F. STEVENSON, VERA FELEKI, PETER RECHNITZER, JOHN R. BEATON
Journal: Circulation Research (1964)

Using the vinyl acetate corrosion cast technique devised by Tepperman and Pearlman, it has been demonstrated that, in the rat, forced physical exercise (treadmill or swimming) causes an increase in apparent coronary tree size provided the exercise is not too strenuous or frequent.
Survival and Clinical Course at Fontan After Stage One Palliation With Either a Modified Blalock-Taussig Shunt or a Right Ventricle to Pulmonary Artery Conduit
Authors: Mark A. Scheurer, Joshua W. Salvin, Vladimiro L. Vida, Francis Fynn-Thompson, Emile A. Bacha, Frank A. Pigula, John E. Mayer, Pedro J. del Nido, David L. Wessel, Peter C. Laussen, Ravi R. Thiagarajan
Journal: Journal of the American College of Cardiology (2008)
Intravenous recombinant tissue-type plasminogen activator in patients with unstable angina pectoris. Results of a placebo-controlled, randomized trial.
Authors: D O Williams, E J Topol, R M Califf, R Roberts, G B Mancini, J M Joelson, S G Ellis, N S Kleiman
Journal: Circulation (1990)

Because thrombus formation may contribute to coronary obstruction in patients with unstable angina pectoris, we performed a pilot investigation to determine whether thrombolytic therapy can relieve coronary narrowing in this acute ischemic syndrome. Sixty-seven patients with rest angina and angiographic evidence of coronary stenosis were randomly assigned to receive either low-dose intravenous recombinant tissue-type plasminogen activator (rt-PA) (0.75 mg/kg over 1 hour), high-dose intravenous rt-PA (0.75 mg/kg over 1 hour; total dose, 100 mg over 6 hours), or intravenous placebo followed by repeat coronary angiography at 24-48 hours to assess change in the severity of coronary narrowing. Each patient also received oral aspirin and intravenous heparin. Mean values of coronary stenosis severity (percent of diameter reduction) declined to a similar extent in each group: placebo, 75 +/- 14% to 72 +/- 14% (p = 0.07); low-dose rt-PA, 75 +/- 16% to 71 +/- 18% (p = 0.03), and high-dose rt-PA, 82 +/- 11% to 77 +/- 17% (p = 0.18), with only the low-dose rt-PA group achieving statistical significance. Resolution of intracoronary filling defects, increase in antegrade flow grade, or both also occurred equally among the three groups. There was considerable variation in individual patient response. Between 29% and 50% of patients within each group demonstrated a decrease in stenosis severity, whereas 50% to 57% noted either improvement in antegrade flow or resolution of intracoronary thrombus. There was no difference in incidence of major bleeding events among the three groups.(ABSTRACT TRUNCATED AT 250 WORDS)
18F-FDG PET Rarely Provides Additional Information to 11C-Methionine PET Imaging in Hyperparathyroidism
Authors: Sugama Chicklore, Klaus-Martin Schulte, Nadia Talat, Johnathan G. Hubbard, Michael O’Doherty, Gary J.R. Cook
Journal: Clinical Nuclear Medicine (2014)

The aim of this study was to assess the utility of combined C-methionine and F-FDG PET/CT imaging in hyperparathyroidism.
Potassium Deficiency and Vacuolar Myopathy
Authors: Shin Joong Oh
Journal: JAMA (1971)

To the Editor.—  Westerman made several excellent points which we tried to convey in our paper. We pointed out the rarity of diureticinduced hypokalemic myopathy and the multicausal aspect of hypokalemia in reported cases.  Though dietary deficiency of potassium and excessive sweating might have played some part in hypokalemia in our case, we were not able to document their role. Chlorthalidone therapy and abuse of laxatives were two documented factors in inducing hypokalemia in our case.
Selfish goals serve more fundamental social and biological goals
Authors: D. Vaughn Becker, Douglas T. Kenrick
Journal: Behavioral and Brain Sciences (2014)

Abstract Proximate selfish goals reflect the machinations of more fundamental goals such as self-protection and reproduction. Evolutionary life history theory allows us to make predictions about which goals are prioritized over others, which stimuli release which goals, and how the stages of cognitive processing are selectively influenced to better achieve the aims of those goals.
Details of patients' consent in studies should be reported
Authors: M. Nylenna
Journal: BMJ (1997)

CONSORT statement on the reporting standards of clinical trials Recommendations are inappropriate for trial reportsEditor-In his editorial on the CONSORT statement Douglas G Altman states that since "only randomised trials have the potential directly to affect patient care ... it is ... reasonable to require higher standards for papers reporting randomised trials than those describing other types of study." 1 But although randomised trials are usually the preferred approach for the unbiased evaluation of treatments, non-randomised observational studies also influence treatment.Because the correct interpretation of observational studies is much more difficult, largely due to uncontrollable biases, their description and analysis call for at least as much care as do randomised trials.Sometimes, of course, randomised comparisons are unnecessary-for example, to determine the value of fetoprotein screening for neural tube defects.CONSORT is the product of deliberations conducted almost entirely through North American journals. 2Journal editors and statisticians are well represented among those involved, but clinicians and others with experience in actually conducting trials less so.Experience of the procedures recommended seems to be limited and not wholly positive.The authors of one trial report who had been persuaded to rewrite it 3 in the structured format expressed mixed feelings: the paper was rendered less readable with "ideas that are logically linked together (such as point estimates with 95% confidence intervals) torn asunder." 4 Inflexibility and a lengthier manuscript were other reported disadvantages.The editor stated that a journal "should change the way it structures articles only when there is good agreement on the new format in the communities we serve" 4 ; this includes writers and readers of trial reports as well as editors.Feedback from the test case 3 or from other commentators does not seem to have materially altered the final version of CONSORT.By announcing its decision, less than a fortnight after publication of CONSORT, the BMJ pre-empted input from many with experience of planning, conducting, and reporting trials.Few will dispute the need for improvements in the reporting of all studies with implications for patient care, whatever their design.But without appropriate consultation, the BMJ seems to have made its decision on CONSORT prematurely.The requirement that randomised trials report the numbers of patients excluded is generally pointless, 5 and making authors indicate where a large number of checklist items are dealt with would be unduly prescriptive.The CONSORT recommendations should not be imposed unilaterally.Others with experience of trial conduct should be consulted on the nature of any guidelines for the reporting of randomised trials and, more importantly, of observational studies of treatments.
Still waiting for functional EU Clinical Trials Register
Authors: B. Wieseler, N. McGauran, T. Kaiser
Journal: BMJ (2011)

Gotzsche and Jorgensen’s comprehensive account of their efforts to obtain clinical trial data from the European Medicines Agency (EMA) highlights the problems researchers still face in healthcare evaluation.1 In its response, the EMA refers to the steps it has undertaken to improve transparency, including the long awaited launch of the EU Clinical Trials Register (EU-CTR).2

The major goal of trial …
The Professional Liability Crisis
Authors: John K. Iglehart
Journal: New England Journal of Medicine (1986)

The professional liability crisis, a consuming interest of America's physicians because of the rising cost of malpractice insurance and its diminishing availability, stands a far better chance of being addressed — if not resolved — now that the federal government, big business, states, municipalities, and a range of others have become involved in seeking solutions to the problem. However, their involvement is unlikely to retard ongoing changes in the nature of medical practice, changes that stem in large part from the issue of professional liability. These changes include higher health care costs, the practice of "defensive medicine," the erosion of . . .
Nanocytology of Rectal Colonocytes to Assess Risk of Colon Cancer Based on Field Cancerization
Authors: Dhwanil Damania, Hemant K. Roy, Hariharan Subramanian, David S. Weinberg, Douglas K. Rex, Michael J. Goldberg, Joseph Muldoon, Lusik Cherkezyan, Yuanjia Zhu, Laura K. Bianchi, Dhiren Shah, Prabhakar Pradhan, Monica Borkar, Henry Lynch, Vadim Backman
Journal: Cancer Research (2012)

Developing a minimally invasive and cost-effective prescreening strategy for colon cancer is critical because of the impossibility of conducting colonoscopy on the entire at-risk population. The concept of field carcinogenesis, in which normal-appearing tissue away from a tumor has molecular and, consequently, nano-architectural abnormalities, offers one attractive approach to identify high-risk patients. In this study, we investigated whether the novel imaging technique partial wave spectroscopic (PWS) microscopy could risk-stratify patients harboring precancerous lesions of the colon, using an optically measured biomarker (L(d)) obtained from microscopically normal but nanoscopically altered cells. Rectal epithelial cells were examined from 146 patients, including 72 control patients, 14 patients with diminutive adenomas, 20 patients with nondiminutive/nonadvanced adenomas, 15 patients with advanced adenomas/high-grade dysplasia, 12 patients with genetic mutation leading to Lynch syndrome, and 13 patients with cancer. We found that the L(d) obtained from rectal colonocytes was well correlated with colon tumorigenicity in our patient cohort and in an independent validation set of 39 additional patients. Therefore, our findings suggest that PWS-measured L(d) is an accurate marker of field carcinogenesis. This approach provides a potential prescreening strategy for risk stratification before colonoscopy.
Use It or Lose It — Do Effortful Mental Activities Protect against Dementia?
Authors: Joseph T. Coyle
Journal: New England Journal of Medicine (2003)

The past 15 years, since the cloning of the gene for amyloid precursor protein, have witnessed breathtaking advances in our understanding of the pathophysiology of Alzheimer's disease, the most common cause of dementia. Most findings point to a final common pathway involving the accumulation in the brain of the toxic β-amyloid peptide, a degradation product of amyloid precursor protein, resulting in progressive neuronal damage and concomitant cognitive deterioration. Notably, the border between Alzheimer's disease and vascular dementia has become increasingly blurred as shared pathologic processes have been identified.Against this background comes the study by Verghese et al. in this . . .
Accentuated Vascular and Endocrine Response to Sq 20881 in Hypertension
Authors: Gordon H. Williams, Norman K. Hollenberg
Journal: New England Journal of Medicine (1977)

We assessed vascular and hormonal responses to inhibition of peptidyldipeptide hydrolase, which converts angiotensin I to angiotensin II (converting enzyme) and degrades bradykinin (kininase II), in subjects given 10 meq of sodium to activate both systems. In nine normal subjects a threshold dose of 30 μg per kilogram of the inhibitor, SQ 20881, modestly influenced mean blood pressure (-5±1 mm Hg, P<0.05), and renal blood flow(+50±8 ml per 100g per minute), plasma renin activity (+2.3±0.6 ng per milliliter per hour), and angiotensin II (-11±3 pg per milliliter) more strikingly (P<0.01). In six patients with essential hypertension the threshold inhibitor dose was reduced to 10 μg per kilogram; 30 μg per kilogram had an enhanced (P<0.01) effect on mean blood pressure (-11±2 mm Hg), renal blood flow (137±20 ml per 100 g per minute), and angiotensin II concentration (-29±12 pg per milliliter). SQ 20881 elevated plasma bradykinin concentration (7.4± 2.6 ng per milliliter, P<0.02) only in the hypertensive patients. Because both renin-angiotensin and kallikrein-bradykinin systems are influenced, vascular responses to SQ 20881 must be interpreted cautiously, but this agent has excellent antihypertensive characteristics. (N Engl J Med 297:184–188, 1977)
Excess of Amino Acid Substitutions Relative to Polymorphism Between X-Linked Duplications in Drosophila melanogaster
Authors: K. Thornton
Journal: Molecular Biology and Evolution (2004)

We have obtained sequence polymorphism data from 13 genes belonging to 5 gene families in Drosophila melanogaster where the K(a)/K(s) between copies is greater than 1. Twelve of these 13 loci are X-linked. In general, there is evidence of purifying selection in all families, as inferred both from levels of silent and replacement variation and insertion/deletion variation, suggesting that the loci are likely functional. Shared polymorphisms indicative of gene conversion between paralogs are rare among the X-linked families, in contrast to available data from autosomal duplicates. McDonald-Kreitman tests between duplicates reveal an excess of amino-acid fixations between copies in the X-linked families, suggesting that the divergence between these loci was driven by positive selection. In contrast, available data from autosomal duplicates show a deficit of fixations, consistent with gene conversion being a strong homogenizing force.
An improved technique of perfusion of the stomach for the study of gastric secretion in the rat.
Authors: G A Pissidis, C G Clark
Journal: Gut (1967)

Synaptic ribbons are large, dynamic structures in the active zone complex of ribbon synapses and important for the physiological properties of these tonically active synapses. RIBEYE is a unique and major protein component of synaptic ribbons. The aim of the present study was to understand how the synaptic ribbon is built and how the construction of the ribbon could contribute to its ultrastructural plasticity. In the present study, we demonstrate that RIBEYE self-associates using different independent approaches (yeast two-hybrid analyses, protein pull downs, synaptic ribbon–RIBEYE interaction assays, coaggregation experiments, transmission electron microscopy and immunogold electron microscopy). The A-domain [RIBEYE(A)] and B-domain [RIBEYE(B)] of RIBEYE contain five distinct sites for RIBEYE–RIBEYE interactions. Three interaction sites are present in the A-domain of RIBEYE and mediate RIBEYE(A)–RIBEYE(A) homodimerization and heterodimerization with the B-domain. The docking site for RIBEYE(A) on RIBEYE(B) is topographically and functionally different from the RIBEYE(B) homodimerization interface and is negatively regulated by nicotinamide adenine dinucleotide. The identified multiple RIBEYE–RIBEYE interactions have the potential to build the synaptic ribbon: heterologously expressed RIBEYE forms large electron-dense aggregates that are in part physically associated with surrounding vesicles and membrane compartments. These structures resemble spherical synaptic ribbons. These ribbon-like structures coassemble with the active zone protein bassoon, an interaction partner of RIBEYE at the active zone of ribbon synapses, emphasizing the physiological relevance of these RIBEYE-containing aggregates. Based on the identified multiple RIBEYE–RIBEYE interactions, we provide a molecular mechanism for the dynamic assembly of synaptic ribbons from individual RIBEYE subunits.
Conservative Management of Tricuspid Regurgitation in Patients Undergoing Mitral Valve Replacement
Authors: NINA S. BRAUNWALD, JOHN ROSS, ANDREW G. MORROW
Journal: Circulation (1967)

Among 100 consecutive patients undergoing mitral valve replacement, 28 had clinically and hemodynamically significant tricuspid regurgitation without tricuspid stenosis. In 21 patients the mitral valve was regurgitant, and in eight it was stenotic. The characteristic murmur of tricuspid regurgitation was present in 27 patients; 25 had abnormal venous distention, 14 peripheral edema, and seven ascites; and in 27 the liver was enlarged more than 4 cm below the costal margin. The mean right atrial pressure was abnormally high in every patient (average 11 mm Hg), and 25 had severe pulmonary hypertension (average systolic pressure 75 mm Hg). At the time of mitral replacement, 25 patients had no operative procedure on the tricuspid valve, and three had a tricuspid annuloplasty. Four patients died, a mortality rate (14%) not different from that in the patients without tricuspid regurgitation. Twenty-four patients were reassessed at postoperative intervals of one to four years (average 30 months). All evidenced symptomatic improvement; 16 observed no dietary restriction of sodium, six ate regular diets without added salt, and only two limited sodium intake more stringently. Postoperatively, mean right atrial pressures averaged 5 mm Hg and systolic pulmonary arterial pressures 39 mm Hg. In many patients with advanced mitral valve disease, associated tricuspid regurgitation is of a functional nature and secondary to right ventricular hypertension and dilatation of the tricuspid annulus. The present results indicate that in such patients tricuspid regurgitation will improve or disappear after mitral replacement and that tricuspid valve replacement is seldom necessary.
Accumulation of a Bone Imaging Agent in Liver Metastases from Prostate Carcinoma
Authors: MICHAEL K. HASEMASN
Journal: Clinical Nuclear Medicine (1983)

A patient with adenocarcinoma of the prostate presented with right upper quadrant abdominal pain and weight loss. Liver biopsy revealed hepatic metastases from prostate carcinoma. A bone scan demonstrated marked uptake of Tc-99m MDP within the hepatic metastases.
A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma
Authors: Ying-Wei Lin, Zanna M. Beharry, Elizabeth G. Hill, Jin H. Song, Wenxue Wang, Zuping Xia, Zhenhua Zhang, Peter D. Aplan, Jon C. Aster, Charles D. Smith, Andrew S. Kraft
Journal: Blood (2009)