tbuckley/cabot-search huggingface dataset:
Home-Based Intervention in Congestive Heart Failure
Authors: Simon Stewart, John D. Horowitz
Journal: Circulation (2002)

Background — It is not known to what extent initially observed benefits of postdischarge programs of care for patients with chronic congestive heart failure (CHF) in respect to event-free survival, readmissions, and healthcare costs persist in the long term. Methods and Results — We prospectively studied the long-term effects of a multidisciplinary home-based intervention (HBI) in a cohort of CHF patients randomly allocated to either to HBI (n=149) or usual care (n=148). During a median of 4.2 years of follow-up, there were significantly fewer primary end points (unplanned readmission or death) in the HBI versus usual care group: a mean of 0.21 versus 0.37 primary events per patient per month ( P &lt;0.01). Median event-free survival was more prolonged in the HBI than usual care group (7 versus 3 months; P &lt;0.01). Fewer HBI patients died (56% versus 65%; P =0.06) and had more prolonged survival (a median of 40 versus 22 months; P &lt;0.05) compared with usual care. Assignment to HBI was both an independent predictor of event-free survival (RR 0.70; P &lt;0.01) and survival alone (RR 0.72; P &lt;0.05). Overall, HBI patients had 78 fewer unplanned readmissions compared with usual care (0.17 versus 0.29 readmissions per patient per month; P &lt;0.05). The median cost of these readmissions was $A325 versus $A660/month per HBI and usual care patient ( P &lt;0.01). Conclusions — The beneficial effects of HBI in reducing frequency of unplanned readmissions in CHF patients persist in the long term and are associated with prolongation of survival.
ASSOCIATIONS OF SERUM CYTOKINES WITH INTRAVASCULAR ULTRASOUND-DERIVED MEASURES OF CORONARY PLAQUE BURDEN AND CLINICAL OUTCOME IN PATIENTS UNDERGOING CORONARY CATHETERIZATION
Authors: Jin M. Cheng, Rohit Oemrawsingh, K.M. Akkerhuis, Hector Garcia, Sanneke De Boer, Robert-Jan van Geuns, Patrick Serruys, Isabella Kardys, Eric Boersma
Journal: Journal of the American College of Cardiology (2013)
Bleeding Renal Vascular Malformations
Authors: Lawrence Steinberg
Journal: JAMA (1969)

A renal arteriovenous malformation produced hematuria in a 28-year-old man. The vascular lesion was characterized and localized by renal arteriography. The site of bleeding was found in the nephrectomy specimen. Surgical intervention, although utilized for this patient, is not always necessary, as bleeding may stop spontaneously.
Epstein-Barr Virus and Unexplained Illness
Authors: JAMES F. JONES
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 June 1985Epstein-Barr Virus and Unexplained IllnessJAMES F. JONES, M.D.JAMES F. JONES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-6-865_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The letter by Drs. Armstrong and Wetterhall (1) in the May issue was gratifying in that our article (2) was read thoroughly. They are correct in citing two errors on our part. One cannot calculate a mean from one titer value, and the legend to Figure 1 should have been labeled differently. Second, there was a mixup in the identification of Patient 4.The other questions raised are perhaps debatable. The correspondence is correct in that socioeconomic status affects the age-adjusted incidence of Epstein-Barr virus infection; however, the populations so affected are not typical of North American...References1. ARMSTRONGWETTERHALL CS. Epstein-Barr virus and unexplained illness [Letter]. Ann Intern Med. 1985;102:722. LinkGoogle Scholar2. JONESRAYMINNICHHICKSKIBLERLUCAS JCLMRD. Evidence for active Epstein-Barr virus infection in patients with persistent, unexplained illnesses: elevated anti-early antigen antibodies. Ann Intern Med. 1985;102:1-7. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1985Volume 102, Issue 6Page: 865-866KeywordsEpstein-Barr virusPopulation statisticsSocioeconomic status Issue Published: 1 June 1985 PDF DownloadLoading ...
IT-10 * SYNERGISTIC CELLULAR INTERACTIONS IN ADOPTIVE IMMUNOTHERAPY LEADS TO IMMUNOLOGIC REJECTION OF MALIGNANT GLIOMA
Authors: C. Flores, C. Pham, D. Snyder, S. Yang, L. Sanchez-Perez, E. Sayour, X. Cui, H. Kemeny, H. Friedman, D. Bigner, J. Sampson, D. Mitchell
Journal: Neuro-Oncology (2014)

Adoptive cellular therapy after lymphodepletive conditioning can induce dramatic clinical responses, but this approach has previously been limited to melanoma due to a lack of reliable methods for expanding tumor-specific lymphocytes from the majority of other cancers. We demonstrate that tumor RNA-pulsed dendritic cells can be used to reliably expand CD4+ and CD8+ tumor-reactive T lymphocytes for curative adoptive cellular therapy in a highly-invasive, chemotherapy- and radiation-resistant malignant glioma model. Curative treatment of established intracranial tumors involved a synergistic interaction between myeloablative conditioning and hematopoietic stem cell transfer, adoptively transferred tumor-specific T cells, and tumor RNA-pulsed dendritic cell (DC) vaccines. By employing this platform we activate a polyclonal population of tumor reactive T cells and have further identified tumor-specific repertoires of tumor-reactive CD8+ T lymphocytes. Furthermore, we have observed a significant increase of clonotypic frequency of tumor-specific CD8+ cells by following TCR β chain expression in mice that are cured of established tumor by adoptive cellular therapy, indicating the ability to potentially predict treatment outcomes in a preclinical setting. Clinical studies exploring the feasibility and potential survival benefit of this platform against both pediatric and adult CNS malignancies are currently underway in our institution. Our adoptive cellular therapy platform has demonstrated superior immunologic treatment of malignant gliomas and holds potential against other solid tumors.
How Will Exercise Capacity Gain Enough Respect?
Authors: Michael S. Lauer
Journal: Circulation (2011)

Jim Fixx collapsed suddenly during a run, dying at 52 years of age of autopsy-proven coronary atherosclerosis.Fixx had popularized interest in the benefits of exercise, in part through his writings about his own self-transformation from a sedentary to a physically active life.In the wake of his sudden death, medical professionals and public followers were confused, and in some cases, dumbfounded.It can be argued that Fixx had beaten the odds by quitting smoking, losing weight, and becoming fit, thereby gaining years of life over what his genetic background foretold.Still, how was it possible that he should succumb to heart disease at a relatively young age, when, through his own hard work, he had realized the highest levels of physical fitness?Fixx and others had argued that physical activity and fitness were powerful promoters of good health and long life, and they had scientific data to back them up.Or so they thought.
Adding omeprazole to clopidogrel reduced GI events and did not increase CV events
Authors: Clara K Chow
Journal: Annals of Internal Medicine (2011)

ACP Journal Club15 March 2011Adding omeprazole to clopidogrel reduced GI events and did not increase CV eventsClara K. Chow, MDClara K. Chow, MDThe George Institute for Global Health, and Westmead Hospital, University of Sydney, Sydney, New South Wales, Australia (C.K.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-6-201103150-02007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationBhatt DL, Cryer BL, Contant CF, et al. Clopidogrel with or without omeprazole in coronary artery disease. N Engl J Med. 2010;363:1909-17. https://pubmed.ncbi.nlm.nih.gov/20925534Clinical Impact RatingsGIM/FP/GP: Hospitalists: Cardiology: Gastroenterology: References1 Lai KC, Lam SK, Chu KM, et al. Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use. N Engl J Med. 2002;346:2033-8. [PMID: 12087138] Google Scholar2 Gurbel PA, Tantry US. Antiplatelet therapy: clopidogrel-PPI interaction, an ongoing controversy. Nat Rev Cardiol. 2011;8:7-8. [PMID: 21170003] Google Scholar3 Gremme T, Steiner S, Seidinger D, et al. The influence of proton pump inhibitors on the antiplatelet potency of clopidogrel evaluated by 5 different platelet function tests. J Cardiovasc Pharmacol. 2010;56:532-9. [PMID: 20729752] Google Scholar4 Gilard M, Arnaud B, Le Gal G, Abgrall JF, Boschat J. Influence of omeprazole on the antiplatelet action of clopidogrel associated to aspirin. J Thromb Haemost. 2006;4:2508-9. [PMID: 16898956] Google Scholar5 Li XQ, Andersson TB, Ahlstrom M, Weidolf L. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004;32:821-7. [PMID: 15258107] Google Scholar6 Lanas A, Garcia-Rodriguez LA, Arroyo MT, et al. Effect of antisecretory drugs and nitrates on the risk of ulcer bleeding associated with nonsteroidal anti-inflammatory drugs, antiplatelet agents, and anticoagulants. Am J Gastroenterol. 2007;102:507-15. [PMID: 17338735] Google Scholar Author, Article, and Disclosure InformationAffiliations: The George Institute for Global Health, and Westmead Hospital, University of Sydney, Sydney, New South Wales, Australia (C.K.C.)This article was published at Annals.org on 1 March 2011. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEnfermedad por reflujo gastroesofágico 15 March 2011Volume 154, Issue 6Page: JC3-7KeywordsHemorrhageMyocardial infarctionPeptic ulcersSafetySafety studiesStable coronary artery diseaseSurgery ePublished: 15 March 2011 Issue Published: 15 March 2011 CopyrightCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Abstract 4898: Polycomb group molecule PHC3 regulates polycomb complex composition and prognosis of osteosarcoma
Authors: Shintaro Iwata
Journal: Cancer Research (2010)

Abstract PHC3 is a member of the human polycomb complex and has been regarded as a candidate tumor suppressor of osteosarcoma. We performed a mutation survey and PHC3 expression analysis by quantitative real-time PCR using ten osteosarcoma cell lines and 42 primary osteosarcoma samples. Relative PHC3 expression values of clinical samples were analyzed with clinical outcomes, and it was suggested that lower PHC3-expressing patients had significantly worse overall survival. Relative PHC3 values of clinical samples were less than those of normal bone tissues, whereas greater than those of cell lines. By denaturing high performance liquid chromatography analysis and direct sequencing, we found a PHC3 missense mutation in U2OS cells, which resulted in arginine56 to proline substitution. The same point mutation existed in four of 42 primary osteosarcoma samples. Regarding functional analysis, PHC3 expression significantly suppressed colony formation of tumor cells. Intriguingly, polycomb repressive complex 1 members, Bmi1 and Ring1b proteins, were reduced in PHC3-expressing cells. Deletion mutant PHC3 expression suggested that the carboxyl terminus of PHC3 has a role in suppression; the above-mentioned point mutation of PHC3 also lost inhibitory activities. Conversely, Bmi1 expression reduced PHC3 at the mRNA level and induced the proliferation of osteosarcoma cells. Taken together, we confirmed the role of PHC3 as a tumor suppressor in osteosarcoma cells and found that PHC3-dependent tumor suppression may be caused by modification of the composition of polycomb repressive complex 1 in cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4898.
Improved Antibiotic Usage Following Introduction of a Novel Prescription System
Authors: William A. Durbin
Journal: JAMA (1981)

We investigated the impact of a novel antibiotic prescription system on antibiotic use. After a two-month baseline monitoring period, an antibiotic prescription form was introduced on surgical and medical wards, which obliged physicians to categorize antibiotic use as prophylactic, empirical (culture results unavailable), or therapeutic. Depending on the category, administration of antibiotics was automatically discontinued after two days (prophylactic), three days (empirical), or seven days (therapeutic) unless the physician renewed the order or specified an alternate duration of administration. In the subsequent two-month intervention period, 233 (60%) of 390 surgical patients received prophylactic antibiotics compared with 281 (68%) of 413 in the baseline period. Mean duration of prophylaxis was reduced from 4.9 +/- 2.4 days to 2.9 +/- 1.6 days. In the intervention period, 11% of patients received their first prophylactic dose postoperatively, compared with a 30% baseline rate. The percentage of urology patients receiving appropriate therapy for urinary tract infection increased from 38% to 89%. No significant changes in antibiotic use were noted on the medical service. This antibiotic prescription system may have a substantial impact on antibiotic use.
Simple method for differentiating between HLA and platelet‐specific antibodies by flow cytometry
Authors: J. Freedman, A. Hornstein
Journal: American Journal of Hematology (1991)

Abstract Since platelets express both platelet‐specific and class I HLA antigens, serum antiplatelet reactivity assessed by most platelet antibody techniques could be due to antibodies with either or both specificities. Flow cytometric analysis of sera for detection of anti platelet antibody commonly employs a purified platelet preparation as target cells. A method is described for investigating sera for platelet antibodies by flow cytometry using a mixture of platelets and lymphocytes. The mixture of lymphocytes and platelets as target cells has the advantage of confirming the presence of the HLA antibodies in reactive sera. The concomitant use of platelets and lymphocytes treated with citric acid, pH3, or with chloroquine (to remove or alter surface HLA antigens without affecting platelet specific antigens) may further assist in identifying antiplatelet antibodies in alloimmunized patients. These techniques may also be useful in platelet crossmatching procedures.
Suprofen, Acute Renal Failure, and Hematuria
Authors: KENNETH ABREO
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 November 1986Suprofen, Acute Renal Failure, and HematuriaKENNETH ABREO, M.D., JACQUE LABARRE, M.D.KENNETH ABREO, M.D.Search for more papers by this author, JACQUE LABARRE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-5-799_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We report a syndrome of severe flank pain, hematuria, and acute renal failure that occurred after ingestion of a single dose of suprofen (Suprol, McNeil Pharmaceutical, Spring House, Pennsylvania), a recently released nonsteroidal anti-inflammatory agent.A 27-year-old man in normal health developed severe bilateral flank pain 2 hours after ingesting 200 mg of suprofen for treatment of a headache. He did not develop gross hematuria. Physical examination showed a blood pressure of 150/94 mm Hg and bilateral flank tenderness. Urinalysis showed trace protein, 5 to 10 erythrocytes/high-power field, 5 leukocytes/high-power field, and no casts. Laboratory tests showed...References1. CARMICHAEL J and SHANKEL S. Effects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal function. Am J Med. 1985;78:992-1000. CrossrefMedlineGoogle Scholar2. ADAMS D, MICHAEL J, BACON P, HOWIE A, MCCONKEY B, and ADU D. Non-steroidal anti-inflammatory drugs and renal failure. Lancet. 1986;1:57-60. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: KENNETH ABREO, M.D.; JACQUE LABARRE, M.D.Affiliations: Louisiana State University Medical Center Shreveport, LA 71130-3932 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCytochrome P450 Inactivation by Pharmaceuticals and Phytochemicals: Therapeutic RelevanceTime-dependent CYP inhibitionAnti-inflammatory analgesics and drugs used in rheumatoid arthritis and gout 1 November 1986Volume 105, Issue 5Page: 799-799KeywordsAcute renal failureBlood pressureHeadachesIngestionLaboratory testsNSAIDsProteins ePublished: 1 December 2008 Issue Published: 1 November 1986 PDF downloadLoading ...
Hiatal Hernia in Iodine-131 Scintigraphy
Authors: Mary Freeman, Paul Roach, Bruce Robinson, Melissa Shields
Journal: Clinical Nuclear Medicine (2003)

There are occasional reports of a hiatal hernia demonstrating thoracic uptake on I-131 scintigraphy. This is a cause of a potential false-positive appearance mimicking a pulmonary or mediastinal metastasis. Hiatal hernia is 1 of a number of causes of false-positive I-131 whole-body scans. Although previous case reports have demonstrated uptake to lie to the left of the midline, this case is slightly unusual in view of the midline appearance of the uptake. Although this appearance could be seen with mediastinal, pulmonary, or prevertebral metastases, hiatal hernia should be considered in the differential diagnosis of uptake in the thoracic midline on I-131 scintigraphy.
SODIUM AND POTASSIUM IODIDS IN ROENTGENOGRAPHY
Authors: DONALD F. CAMERON
Journal: JAMA (1918)

A few weeks ago, in a preliminary report,1attention was called to some experimental results in the use of potassium and sodium iodids as opaque mediums in roentgenography. Since this report was made, these solutions have been put to practical use in a sufficient number of cases to warrant a report of their clinical application.  PREPARATION OF SOLUTIONS  For pyelography, a 25 per cent, aqueous solution of sodium or potassium iodid is used. Thus, 100 gm. of solution is made by dissolving 25 gm. of the salt in 75 c.c. of water. For cystograms, a 15 per cent. solution gives sufficient density. As was noted in the previous article, these solutions are stable, neutral in reaction, and cause no precipitation in urine or bloody urine. On standing, they become slightly yellow, but this causes no trouble. There are no special precautions to be observed in preparing the solutions, and
Clinical utility of random anti-tumour necrosis factor drug testing and measurement of anti-drug antibodies on long-term treatment response in rheumatoid arthritis
Authors: Meghna Jani, Hector Chinoy, Richard B Warren, Christopher E M Griffiths, Darren Plant, Ann W Morgan, Anthony G Wilson, Kimme L Hyrich, John Isaacs, Anne Barton
Journal: The Lancet (2015)
Changes in serial blood lead levels during pregnancy.
Authors: S J Rothenberg, S Karchmer, L Schnaas, E Perroni, F Zea, J Fernández Alba
Journal: Environmental Health Perspectives (1994)

The first step in modeling lead kinetics during pregnancy includes a description of sequential maternal blood lead (PbB) during pregnancy and the factors controlling it. We analyzed PbB of 105 women living in the Valley of Mexico from week 12 to week 36 of pregnancy and again at parturition. We also used data from all women contributing blood at any stage of pregnancy to determine antecedents of PbB. Pregnancies were uneventful, and offspring were normal. Although geometric mean PbB level averaged around 7.0 micrograms/dl (0.34 mumol/l), with a range of 1.0-35.5 micrograms/dl throughout pregnancy, analysis of variance revealed a significant decrease in mean PbB from week 12 to week 20 (1.1 micrograms/dl) and various significant increases in mean PbB from week 20 to parturition (1.6 micrograms/dl). Regression analyses confirmed the positive linear PbB trend from 20 weeks to parturition and additional contributions of dietary calcium, reproductive history, lifetime residence of Mexico City, coffee drinking, and use of indigenous lead-glazed pottery. Although decreasing hematocrit has been suggested to explain first-half pregnancy PbB decrease, the time course of hematocrit decrease in the present study did not match the sequential changes in PbB. While hemodilution and organ growth in the first half of pregnancy may account for much of the PbB decrease seen between 12 and 20 weeks, the remaining hemodilution and accelerated organ growth of the last half of pregnancy do not predict the trend toward increasing maternal PbB concentration from 20 weeks to delivery. Mobilization of bone lead, increased gut absorption, and increased retention of lead may explain part of the upward PbB trend in the second half of pregnancy. Reduction of lifetime lead exposure may be required to decrease risk of fetal exposure.
Petroleum Internally Not Endorsed by American Therapeutic Society.
Authors: N. P. Barnes
Journal: JAMA (1904)

consanguineous marriages have a tendency to produce mental unsoundness receives little support from the census figures.Visit of French Physicians to London.A visit of leading members of the French profession to Lon¬ don has been arranged, to include Professors Bouchard, Lucas- Champioiinière, Chauffard, Landouzy, Lermoyez, Marie and Sebileau.It is understood that they desire especially to ob¬ serve the system of clinical teaching and study in London.Visits to the Royal College of Surgeons, the Lister Institute, and the laboratories on the Embankment will be arranged.A banquet will be given to the visitors, and committees of enter¬ tainment and escort are appointed.Mr. Chamberlain and Preventive Medicine.The Royal Institution of Public Health has given a banquet to Mr. Chamberlain in recognition of his services to preventive
Review: Neuraminidase inhibitors reduce symptomatic influenza; oseltamivir does not reduce hospitalizations
Authors: Peter S. Millard
Journal: Annals of Internal Medicine (2014)

Source Citation Jefferson T, Jones MA, Doshi P, et al. Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Cochrane Database Syst Rev. 2014;4:CD008965. 24718923
Passive Transfer of HIV Antibody by Hepatitis B Immune Globulin
Authors: Walter F. Schlech
Journal: JAMA (1989)

Two newborns of mothers carrying hepatitis B and at high risk for human immunodeficiency virus (HIV) infection developed HIV-positive test results by enzyme-linked immunosorbent assay and Western blot tests after birth. Both had been administered hepatitis B immune globulin within 48 hours of birth. Serological tests detected HIV antibody as long as 17 days after birth. Both newborns had received lots of hepatitis B immune globulin containing antibody to HIV. While hepatitis B immune globulin cannot transmit HIV infection to recipients, physicians should be aware that administration of older lots of this preparation may result in transiently positive tests for HIV antibody in the recipients. Lots manufactured from screened plasma do not contain antibody to HIV. (<i>JAMA</i>1989;261:411-413)