tbuckley/cabot-search huggingface dataset:
Reproductive Endocrine Therapeutics
Authors: Stephen L. Corson
Journal: JAMA (1990)

This is a work in 17 chapters with 27 contributors. As described in the preface, the unifying aspect of the text is one of the medical approach to gynecologic problems. Therefore, this is actually an endocrinologic text, as suggested by its title. It is clinically directed rather than basic-science oriented. The general plane on which it is written will be below the needs of most reproductive endocrinologists but is right on target for the mainstream of gynecologic practice. Many straightforward endocrine problems can be satisfactorily treated by the general gynecologist, and only complicated cases need to be sent for further consultation. For instance, the treatment of menopause certainly should be within the realm of the general gynecologist, but precocious puberty would probably be best treated by one with more formalized training. The chapters are generally concise and well referenced. Even if the general gynecologist does not induce ovulation with human
Morphological characteristics of coronary plaque in patients with low level of high-density lipoprotein
Authors: Byung-il W. Choi, So-Yeon Choi, Hyuk-Jae Chang, Tae-Young Choi, Myeong-Ho Yoon, Gyo-Seung Hwang, Joon-Han Shin, Han-Soo Kim, Seung-Jea Tahk
Journal: Journal of the American College of Cardiology (2003)
Myocardial depression in streptococcal cellulitis.
Authors: J D Edwards, P M Schofield
Journal: BMJ (1984)

A previously healthy woman developed streptococcal cellulitis of the leg after falling and lacerating her knee. On admission her blood pressure was unrecordable and her respiratory rate greater than 60 beats/minute. Mechanical ventilation was necessary, and plasma volume expansion was started, with little effect. Infusion of dopamine restored the blood pressure to 150/90 mm Hg, but interrupting the infusion for as little as 30 seconds resulted in profound hypotension. Insertion of a second central venous catheter allowed the dopamine to be given continuously, and the infusion was stopped successfully four days after her admission. She eventually made a complete recovery. This case highlights the need for intensive supportive treatment in many streptococcal infections and, in particular, the need for inotropic support.
Purified factor VIII
Authors: E G D Tuddenham, M Laffan
Journal: BMJ (1995)

There is still, however, substantial disagreement on what these distinctions are and which are most relevant.Generally, parents, in conjunction with health care pro- viders, are the most appropriate people to make life and death decisions for their children.Decisions by parents to stop treatment are made thousands of times each year without court supervision.Loving, caring families, presumably like that of Thomas Creedon, should not therefore routinely be subjected to undue public and legal scrutiny when they face such an agonising decision as whether to stop treatment on their child.But health care providers must always be on the alert for parents who do not speak in the best interests of their child or have conflicts of interest that may bias their views.Medical technology has reached a point at which the public, including the courts, must be more involved in these cases and educated on the basic principles, such as the distinctions between stopping treatment and euthanasia.One way is through landmark legal cases.But society needs to debate these issues more publicly and to develop ethical, medical, legal, and social policies on how to deal with them.
Abstract PR01: Rebastinib, a selective TIE2 kinase inhibitor, decreases TIE2-expressing macrophages, reduces metastasis, and increases survival in murine cancer models
Authors: Daniel L. Flynn, Michael D. Kaufman, Cynthia B. Leary, Molly M. Hood, Wei-Ping Lu, Benjamin A. Turner, Scott C. Wise, Marc S. Rudoltz, Bryan D. Smith
Journal: Cancer Research (2015)

Abstract In the tumor microenvironment, TIE2 expression on tissue macrophages, bone marrow derived TIE2-expressing monocytes (TEMs), osteoclasts, and vascular endothelial cells promotes tumor invasiveness, dissemination, and metastasis. Additionally, a subset of TIE2-expressing macrophages, located within specialized vascular structures known as tumor microenvironment for metastases (TMEMs), are linked to intravasation of cancer cells into circulation and dissemination to metastatic sites. Rebastinib is a picomolar inhibitor of TIE2 kinase, and exhibits an extraordinarily long off-rate from TIE2, measured to be over 24 hours in a cell-based assay. Herein, we examine the efficacy of rebastinib in the polyoma middle-T antigen (PyMT) syngeneic mouse breast cancer model. In this model, PyMT breast cancer cells are implanted in the mammary fat pad, and primary tumor growth leads to lung metastasis, which is known to be modulated by TEMs and TMEM vascular structures. We examined multiple dosing schedules of rebastinib in combination with anti-tubulin agents (ATAs). Rebastinib treatment in this model significantly ablated TEMs in the primary tumor stroma and caused a significant decrease in lung metastases. Furthermore, the combination of rebastinib with ATAs, even with once or twice weekly oral dosing of rebastinib, led to a significant further decrease in lung metastases compared to single-agent treatment with ATAs. Rebastinib also enhanced the activity of ATAs in reducing primary tumor growth and regrowth of tumor post-resection. TIE2 inhibition with targeted therapy represents a novel treatment approach for metastatic breast cancer and other cancers that rely on TEMs and TMEMs for growth and metastasis. As such, rebastinib has been selected for further clinical development in solid tumors with a Phase 1b trial being planned for 2014. This abstract is also presented as Poster A5. Citation Format: Daniel L. Flynn, Michael D. Kaufman, Cynthia B. Leary, Molly M. Hood, Wei-Ping Lu, Benjamin A. Turner, Scott C. Wise, Marc S. Rudoltz, Bryan D. Smith. Rebastinib, a selective TIE2 kinase inhibitor, decreases TIE2-expressing macrophages, reduces metastasis, and increases survival in murine cancer models. [abstract]. In: Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; 2014 Feb 26-Mar 1; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(1 Suppl):Abstract nr PR01. doi:10.1158/1538-7445.CHTME14-PR01
Experimental Pulmonary Arterial Hypertension in the Newborn Calf
Authors: John H. K. Vogel, Keith H. Averill, Peter E. Pool, S. Gilbert Blount
Journal: Circulation Research (1963)

1. The left pulmonary artery was ligated in day-old calves. All animals developed pulmonary arterial hypertension with resting mean pressures as high as 114 mm Hg. This was associated with a reduction in the pulmonary arterial vascular bed of the right lung and right ventricular hypertrophy. The longest survival has been five months; death being associated with congestive heart failure. 2. Pulmonary hypertension developed without concomitant rise of pulmonary arterial wedge pressure. 3. Inhalation of 13% O 2 caused an average rise of 45 mm Hg in mean pulmonary arterial pressure, as compared with 21 mm Hg in normal calves and nine in yearling steers. 4. Inhalation of 41% or 100% O 2 caused an average decrease of 29 mm Hg in pulmonary arterial pressure, as compared with 14 mm Hg in normal calves. 5. Acetylcholine reduced the elevated pulmonary arterial pressure suggesting that vaso-constriction played an important role in the development of the pulmonary hypertension. Tolazoline was ineffective. 6. The spectrum of reactivity of the pulmonary vascular bed among species as well as within a given species is illustrated.
Telomerase activity is required for bleomycin-induced pulmonary fibrosis in mice
Authors: Tianju Liu, Myoung Ja Chung, Matthew Ullenbruch, Hongfeng Yu, Hong Jin, Biao Hu, Yoon Young Choi, Fuyuki Ishikawa, Sem H. Phan
Journal: Journal of Clinical Investigation (2007)

In addition to its well-known expression in the germline and in cells of certain cancers, telomerase activity is induced in lung fibrosis, although its role in this process is unknown. To identify the pathogenetic importance of telomerase in lung fibrosis, we examined the effects of telomerase reverse transcriptase (TERT) deficiency in a murine model of pulmonary injury. TERT-deficient mice showed significantly reduced lung fibrosis following bleomycin (BLM) insult. This was accompanied by a significant reduction in expression of lung α-SMA, a marker of myofibroblast differentiation. Furthermore, lung fibroblasts isolated from BLM-treated TERT-deficient mice showed significantly decreased proliferation and increased apoptosis rates compared with cells isolated from control mice. Transplantation of WT BM into TERT-deficient mice restored BLM-induced lung telomerase activity and fibrosis to WT levels. Conversely, transplantation of BM from TERT-deficient mice into WT recipients resulted in reduced telomerase activity and fibrosis. These findings suggest that induction of telomerase in injured lungs may be caused by BM-derived cells, which appear to play an important role in pulmonary fibrosis. Moreover, TERT induction is associated with increased survival of lung fibroblasts, which favors the development of fibrosis instead of injury resolution.
The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes
Authors: Oliver Borst, Eva-Maria Schmidt, Patrick Münzer, Tanja Schönberger, Syeda T. Towhid, Margitta Elvers, Christina Leibrock, Evi Schmid, Anja Eylenstein, Dietmar Kuhl, Andreas E. May, Meinrad Gawaz, Florian Lang
Journal: Blood (2011)
Neutral Mutations and Neutral Substitutions in Bacterial Genomes
Authors: H. Ochman
Journal: Molecular Biology and Evolution (2003)

Molecular evolutionary biologists usually assess the underlying spectrum of mutations within a bacterial genome by examining substitutions that occur at sites believed to be under no selective constraints. Alternatively, bacterial mutation rates can also be estimated in a variety of experimental systems. The two classes of changes occurring in DNA sequences—i.e., mutations and neutral substitutions—are, in theory, identical; however, the rates and patterns of mutations in bacteria, as inferred from sequence comparisons, often differ significantly from those derived experimentally. These differences have resulted in conflicting interpretations of the nonselective forces that affect mutation rates.
In vitro proliferation and cloning of CD3- CD16+ cells from human thymocyte precursors.
Authors: M C Mingari, A Poggi, R Biassoni, R Bellomo, E Ciccone, N Pella, L Morelli, S Verdiani, A Moretta, L Moretta
Journal: The Journal of Experimental Medicine (1991)

Purified CD3-4- thymocytes were obtained by depletion of CD3+ and CD4+ cells from fresh thymocyte suspensions. 5-15% of these cells were found to express CD16 antigen, while other natural killer (NK) cell markers were virtually absent. Double fluorescence analysis revealed that 20-40% of thymic CD16+ cells coexpressed CD1, while approximately half were cyCD3+. When cultured in the presence of peripheral blood lymphocytes and H9 leukemia cell line as a source of irradiated feeder cells and interleukin 2 (IL-2), CD3-4- thymocytes underwent extensive proliferation. In addition, after 1-2 wk of culture, 30-50% of these cells were found to express CD16 surface antigen. Cloning under limiting dilution conditions of either CD3-4- or CD3-4-16- thymocytes in the presence of irradiated H9 cells resulted in large proportions (approximately 50%) of CD16+ clones. On the basis of the expression of surface CD16 and/or cyCD3 antigen, clones could be grouped in the following subsets: CD16+ cyCD3+; CD16+ cyCD3-; CD16- cyCD3+; and CD16- cyCD3-. All clones expressed CD56 surface antigen, displayed a strong cytolytic activity against NK sensitive (K562) and NK-resistant (M14) target cells, and produced IFN-gamma and tumor necrosis factor, but not IL-2. Similar to peripheral NK cells, thymic CD16+ cells expressed transcripts for CD16 and for CD3 epsilon (Biassoni, R., S. Ferrini, I. Prigione, A. Moretta, and E.O. Long, 1988. J. Immunol. 140:1685.) and zeta chains (Anderson, P., M. Caligiuri, J. Ritz, and S.F. Schlossman. 1989. Nature [Lond.]. 341:159). Therefore, it appears that cells that are phenotypically and functionally similar to CD3- CD16+ NK cells may arise from immature thymocytes.
Death from exposure.
Authors: M. C. Munday
Journal: BMJ (1967)

Death from Exposure SIR,-Many mountaineering deaths are put down as being due to " exposure," either alone or in conjunction with injuries.These unfortunate people are often diagnosed as being dead by lay people on the hill, and treated accordingly-that is, head covered, often by plastic or similar impervious material.Perhaps, therefore, it would be wise to emphasize the difficulties of diagnosing death in a patient suffering from hypo- thermia.Mountain Rescue Figures in 1961-5 for Great Britain
A Clinician's Guide to Menopause
Authors: Kelly E. Arduino
Journal: Annals of Internal Medicine (1998)

Medical Writings15 January 1998A Clinician's Guide to MenopauseKelly E. Arduino, MAKelly E. Arduino, MARush-Presbyterian-St. Luke's Medical Center, Chicago, IllinoisSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-2-199801150-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Stewart DE, Robinson GE; eds. 243 pages. Health Press International; 1997. $38.00. ISBN 0880487542.Field of medicine: Gynecology, psychiatry, and psychology.Format: Hardcover book.Audience: The Clinical Practice series is targeted toward clinicians “working outside the hospital setting,” particularly mental health professionals and psychiatrists.Purpose: To apply the most current research on menopause and its treatment to clinical situations, emphasizing psychological and social factors.Content: A basic overview of the symptoms and confounding psychosocial aspects of menopause precedes an evenhanded presentation of medical, hormonal, psychological, and psychiatric treatments. A chapter on cultural differences in menopause contains a review of international ... Author, Article, and Disclosure InformationAffiliations: Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1998Volume 128, Issue 2Page: 159-160KeywordsGlobal healthHealth careHealth information technologyHormonal therapyHormonesMenopauseMood disordersPsychiatry and mental healthPsychologyPsychopharmacology ePublished: 15 August 2000 Issue Published: 15 January 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Invasive and Metastatic Potential of a v-Ha-ras-Transformed Human Bronchial Epithelial Cell Line
Authors: R. Daniel Bonfil, Roger R. Reddel, Hitoshi Ura, Reuven Reich, R Fridman, Curtis C. Harris, Andres J. P. Klein-Szanto
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Invasive and Metastatic Potential of a v-Ha-ras-Transformed Human Bronchial Epithelial Cell Line Get access R. Daniel Bonfil, R. Daniel Bonfil Search for other works by this author on: Oxford Academic PubMed Google Scholar Roger R. Reddel, Roger R. Reddel Search for other works by this author on: Oxford Academic PubMed Google Scholar Hitoshi Ura, Hitoshi Ura Search for other works by this author on: Oxford Academic PubMed Google Scholar Reuven Reich, Reuven Reich Search for other works by this author on: Oxford Academic PubMed Google Scholar R Fridman, R Fridman Search for other works by this author on: Oxford Academic PubMed Google Scholar Curtis C. Harris, Curtis C. Harris Search for other works by this author on: Oxford Academic PubMed Google Scholar Andres J. P. Klein-Szanto Andres J. P. Klein-Szanto Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 8, 19 April 1989, Pages 587–594, https://doi.org/10.1093/jnci/81.8.587 Published: 19 April 1989 Article history Received: 22 August 1988 Revision received: 17 January 1989 Accepted: 10 February 1989 Published: 19 April 1989
Matters of Life and Death: Risks vs. Benefits of Medical Care
Authors: Roger W. Evans
Journal: JAMA (1985)

This is an unusual book. The author, a physician, proclaims "this is a book for patients, not for doctors." If his advice is heeded, he will have done his own profession a disservice. This book should be read by doctors, as well as by patients. The purpose of this book, explicitly stated by the author, is as follows: "To alert you to the risks and benefits of medical diagnosis and therapy." Indeed, throughout the book the author encourages the patient to carefully weigh the risks and benefits involved in health care provision. To assist in the making of informed decisions, the author urges us to identify an "ombudsdoctor," who is a physician serving as the advocate and representative of the patient in medical encounters. From the author's perspective, patients must take a more active role in their own care because "every doctor is frequently uncertain and frequently wrong. As a
Heroin users: notifications to the Home Office Addict's Index by general practitioners.
Authors: J R Robertson, A B Bucknall
Journal: BMJ (1985)

In a study of 113 heroin users who attended a Scottish general practice of 11 doctors information was gathered retrospectively regarding notification of these patients to the Home Office. The doctors were questioned about their practices for notification. Surprisingly few of the patients had been correctly notified and renotified where appropriate, and there was great variation in the doctors9 notification practices, particularly with respect to defining addiction. General practitioners are now the largest source of notifications of controlled drug users, and the statistics issued by the Home Office must be interpreted in the light of their notification practices.
Experimental Fibrositis due to a Virus, and Some Observations on the Experimental Production of Arthritis
Authors: M. H. Gordon
Journal: Annals of the Rheumatic Diseases (1939)

A VIRUS OBSERVATIONS were made in the first place with a pathogenic strain of variola-lapine, the M4 strain of Tulloch originally raised by Sobernheim by inoculating rabbits with smallpox crusts.In order to develop its virulence to the fullest degree, this virus was first passaged through the testis of a series of rabbits.The chief material used consisted of a 1: 50 suspension of the passage testis in broth that was centrifuged for thirty minutes at 3,000 r.p.m. to remove the heavier particles.The clear supernatant fluid was sterile on culture and active on the rabbit's skin up to a dilution of over 1:1,000,000.In some experiments a broth suspension of the young papules on the rabbit's skin three days after scarification was employed, and the results were similar.The inquiry was undertaken expressly in view of the present discussion, and the primary object was to see if by repeated doses venously this M4 virus produced malignant endocarditis in rabbits.It was found, however, that by giving two doses venously separated by an interval of four days the rabbits developed symptoms of arthritis (limp on moving).When the dose was too large or the virus especially virulent a polyarthritis developed, but usually only one hind leg was affected.On palpating the affected joint the lesion was found to be peri- articular rather than articular, and the commonest site was in the region of the insertion of the tendo Achillis (see Fig. 1).These periarticular swellings never suppurated, and if left alone gradually cleared up.When the rabbit was killed at an early * Discussion on the AEtiology of-Acute Rheumatism and Rheumatoid
Patients' Choices and the Medical Commons
Authors: Marianne C. Mann
Journal: Annals of Internal Medicine (1993)

Letters15 July 1993Patients' Choices and the Medical CommonsMarianne C. Mann, MD, John Votto, MD, and Michael J. McNamee, MDMarianne C. Mann, MDSearch for more papers by this author, John Votto, MDSearch for more papers by this author, and Michael J. McNamee, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-2-199307150-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We find the letter from Drs. Jederlinic and Rockwell regarding the expense involved in the care of our patient shocking. We reject the notion that our patient's survival resulted from a misuse of resources, despite a hospital bill of $120 593, of which $56 571 was collected.We did indeed discuss the complex ethical issue of providing expensive alternative therapies to a patient who refuses traditional therapies and cited an article that reviews this topic [1]. We are unaware of any societal consensus that a patient's therapeutic options be limited because of choices of conscience (or even because ...REFERENCE1. Chervanak FA, McCullough LB. Justified limits on refusing intervention. Hastings Cent Rep. 1991; 21:12-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 July 1993Volume 119, Issue 2Page: 170-171KeywordsBlood transfusionMedical ethicsPatientsSelf harmVentilators Issue Published: 15 July 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Epidemiology of Osteoarthrosis
Authors: J. Ball
Journal: Annals of the Rheumatic Diseases (1982)

Book reviews 323and of immunofluorescence and immunoperoxidase tech-mechanisms found in skeletal muscle.There are then separ- niques.Comparable analyses incorporating these newer ate parts devoted to diseases of the anterior horn cell, the methods will undoubtedly follow.peripheral nerve, muscle itself, and the neuromuscular Stemming directly from the present volume and in-junction.corporated in the papers to which I refer above is the appli-The book is presumably intended for those specialists cation to synovial diagnosis of the approach that is coming dealing with neuromuscular disease, and therefore must to be called 'probability diagnosis', an advance in histostand comparison with Walton's Disorders of Voluntary pathology that reflects the anxiety of many contemporary Muscle, the fourth edition of which has recently appeared.It investigators to apply all that is best in statistics and com-has one advantage in this respect, in that it is not a multiputer technology to the interpretation of the often difficult author text.This advantage is sustained, however, only if problems posed by synovial biopsies.The results are a the authors are able to cover the wide area of the subject
Cot death and prone sleeping position in The Netherlands.
Authors: G. A. de Jonge, A. C. Engelberts, A. J. Koomen-Liefting, P. J. Kostense
Journal: BMJ (1989)

La mort subite du nourrisson est environ 5 fois plus frequente chez ceux qui dorment en pronation. Cette position pour le sommeil n'est conseillee que dans certains cas: prematurite, reflux gastro-œsophagien frequent, syndrome de Pierre Robin, scoliose