tbuckley/cabot-search huggingface dataset:
Points: Impotence: treatment by autoinjection of vasoactive drugs
Authors: K M Desai, J C Gingell
Journal: BMJ (1987)

maladministration of the HM(61)112 procedure or its successor.There is a parallel-the Police Complaints Board.Even worse than HM(61)112 for disciplining doctors, however, is RHB(51)81, where the employing authority can be the complainant, prosecuting council, judge, and appeal court while the suspended doctor is denied any legal repre- sentation although the lawyers acting on behalf of the employer are allowed to be present.It is difficult to have any confidence in such a system.
Hepatic Amebic Abscess
Authors: Alfred E. Stillman
Journal: JAMA (1974)

FOUR recent reports have illustrated the failure of large doses of metronidazole to cure hepatic amebic abscesses.<sup>1-4</sup>Metronidazole is considered the drug of choice in the treatment of invasive amebiasis.<sup>5</sup>' In combination with abscess drainage, metronidazole thus far has been uniformly successful in the therapy of hepatic amebic abscess.<sup>4,6</sup>A patient with hepatic amebic abscess was recently studied at Tucson Medical Center; the abscess failed to respond to a simultaneous combination of metronidazole therapy and surgical drainage of the abscess. <h3>Report of a Case</h3> A 24-year-old Mexican woman was referred to Tucson Medical Center because of jaundice that developed at childbirth. Two weeks before admission, she experienced onset of pleuritic right flank pain that radiated to the right shoulder. Two days before admission, she became jaundiced, and one day before admission, she gave birth to a stillborn infant. She had not been ill previously except for mild
Amiodarone versus amiodarone and a type IA agent for treatment of patients with rapid ventricular tachycardia.
Authors: F E Marchlinski, A E Buxton, J M Miller, J A Vassallo, B T Flores, M E Josephson
Journal: Circulation (1986)

Induction of rapid ventricular tachycardia or fibrillation during therapy with amiodarone is associated with an increased risk of sudden death. To determine whether the addition of a type IA antiarrhythmic agent to therapy would improve outcome, 37 patients in whom ventricular tachyarrhythmia of a cycle length less than 350 msec was induced after 14 +/- 2 days of amiodarone were randomly assigned to therapy with amiodarone alone (group 1, 20 patients) or amiodarone plus type IA agent (group 2, 17 patients). Type IA therapy consisted of procainamide in 13 patients and quinidine in four procainamide-intolerant patients. To assess the short-term effects of a type IA agent on inducibility of ventricular tachyarrhythmia, cycle length, and hemodynamic tolerance, 16 of 20 patients in group 1 and all patients in group 2 underwent repeat programmed stimulation after the intravenous administration of procainamide during amiodarone therapy (mean procainamide serum concentration 7.2 +/- 2.0 micrograms/ml). Procainamide prevented induction of sustained arrhythmia in only two of 33 patients. Procainamide increased the cycle length of induced ventricular tachycardia from 283 +/- 30 to 352 +/- 46 msec (p less than .001). After the addition of procainamide, 16 of 31 patients vs 10 of 37 patients on amiodarone alone had an induced arrhythmia that was tolerated hemodynamically (p less than .05). There were no differences between groups 1 and 2 with respect to patient or arrhythmia characteristics, response to short-term procainamide, or duration of follow-up. The mean follow-up for all patients was 14 +/- 10 months.(ABSTRACT TRUNCATED AT 250 WORDS)
Rat Arterial Wall Retains Myointimal Hyperplastic Potential Long After Arterial Injury
Authors: Martin G. Sirois, Michael Simons, David J. Kuter, Robert D. Rosenberg, Elazer R. Edelman
Journal: Circulation (1997)

Background Many novel molecular and pharmacological modalities have been proposed for the treatment of accelerated vascular diseases. Yet the fundamental question remains of whether the vessel wall can be treated once only or whether single-dose therapy simply delays the inevitable processes that lead to intimal hyperplasia. Since platelet adhesion and aggregation are critical events in vascular healing, we sought to determine whether the injured blood vessel would retain its myointimal potential after reversal of even prolonged periods of thrombocytopenia. Methods and Results A novel nonimmune method sustained thrombocytopenia and suppressed postinjury neointimal hyperplasia by 88%. Infusion of fresh platelets, even 14 days after initial denuding injury, restored the full neointimal hyperplastic potential. Platelet depletion presumably removed factors chemotactic for vascular smooth muscle cells but had no effect on the overexpression of the platelet-derived growth factor receptor-β (PDGFR-β) subunit after vascular injury. In native vessels, 26.5±2.5% of medial smooth muscle cells expressed PDGFR-β. In all animals, medial PDGFR-β expression doubled 2 weeks after endothelial denudation and was evident in up to 74.5±2.5% of the cells forming the neointima. Conclusions Thus, though the hyperplastic potential of the injured blood vessel can be delayed with removal of growth stimuli, it is not lost forever, and if the media is not made quiescent, neointimal hyperplasia is simply delayed rather than prevented. These results may have a profound effect on our understanding and treatment of accelerated proliferative vascular diseases.
Pityriasis rosea and discoid eczema: dose related reactions to treatment with gold.
Authors: S M Wilkinson, A G Smith, M J Davis, D Mattey, P T Dawes
Journal: Annals of the Rheumatic Diseases (1992)

Sixteen cases of either a pityriasiform or discoid eczematous rash occurring in patients with rheumatoid arthritis receiving treatment with gold (sodium aurothiomalate and auranofin) were studied. The results suggest that this is a dose related, not allergic, reaction to gold. The development of this rash is not an absolute indication to stop treatment with gold. Control can often be effected with potent topical steroids or a reduction in the dose or frequency of treatment with gold.
Diagnosis of hepatitis delta virus infection
Authors: Manuel Rodriguez, Ana Martinez, Pedro Sala, Sabino Riestra, Adolfo Suárez, Luis Rodrigo, Maria Buti
Journal: Hepatology (1991)

We read with interest the editorial by Di Bisceglie and Negro (1) and the paper by Buti et al. (21, in which the authors write about diagnosis of hepatitis delta virus (HDV) infection.In their editorial, Di Bisceglie and Negro (1) identify the discrepancy that exists in the reports with regard to the usefulness of the test for delta antigen (HDAg) in the diagnosis of acute HDV infection.We tested for HDAg by enzyme-linked immunoassay (Deltassay Ag; Noctech Ltd, Dublin, Ireland) 101 serum samples from 38 patients with HBV and HDV coinfection.The samples were obtained at different times after the onset of symptoms of acute hepatitis: 12 during wk 1, 13 during wk 2, 20 during wk 3, 19 during wk 4 and 37 between wk 5 and wk 8. Positivity for HDAg was 83.3% in the first week, 100% in the second, 65% in the third and 42% in the fourth and 8.1% between the fifth and eighth weeks.Persistence of HDAg was < 2 wk in all patients except for two in whom HDAg remained positive-for 3 wk in one patient and for 5 wk in the other.Compared with IgM antibody to HDV virus (anti-HD) and IgG anti-HD (Sorin Biomedical; Saluggia, Italy), HDAg was the best marker for acute HDV infection during the first and the second weeks.Our findings are similar to those observed by Shattock and Morgan (3) and by Buti et al. ( 4) -probably because we used the same assay-and they support the clinical usefulness of the test for HDAg.In chronic HDV infection serum HDAg is rarely detected, as noted by Di Bisceglie and Negro (1).However, we detected HDAg by enzyme-linked immunoassay in 10
Advertising and Tobacco
Authors: Emerson Foote
Journal: JAMA (1981)

Statement Prepared for the Toronto Transit Commission  It is not easy for me, a citizen of the United States, to make representations to a transit authority in another country, especially when my representations encourage a decision that would appear not to be in the authority's best financial interest.  It is my understanding that the Toronto Board of Health has recommended that the Toronto Transit Commission refuse to accept future tobacco advertising. Both bodies are to be commended: your local health board for taking this preventive medical initiative and your commission for agreeing to review the matter. It is also my understanding that your local municipal councils, board of education, parent-teacher organizations, and various health and consumer groups all have supported the health board's recommendation. With a coalition like this, it is possible to make a desired health decision with widespread community backing.  I cannot overstate the value of a positive
O'Brien's actinic granuloma
Authors: J. PRENDIVILLE, W.A.D. GRIFFITHS, R.RUSSELL JONES
Journal: British Journal of Dermatology (1985)

Journal Article O'Brien's actinic granuloma Get access J. PRENDIVILLE, J. PRENDIVILLE Department of Dermatology, Ealing Hospital, Southall, Middlesex, U.K. Dr J.Prendiville, Department of Dermatology, Ealing Hospital, Uxbridge Road, Southall, Middx, UB1 3HW, U.K. Search for other works by this author on: Oxford Academic Google Scholar W.A.D. GRIFFITHS, W.A.D. GRIFFITHS St John's Hospital for Diseases of the Skin, London WC2H 7BJ, U.K. Search for other works by this author on: Oxford Academic Google Scholar R.RUSSELL JONES R.RUSSELL JONES St John's Hospital for Diseases of the Skin, London WC2H 7BJ, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue 3, 1 September 1985, Pages 353–358, https://doi.org/10.1111/j.1365-2133.1985.tb02090.x Published: 01 September 1985 Article history Accepted: 28 March 1985 Published: 01 September 1985
Most individuals with either segmental or non-segmental vitiligo display evidence of bilateral cochlear dysfunction
Authors: T.S. Anbar, M.M. El-Badry, J.A. McGrath, E.S. Abdel-Azim
Journal: British Journal of Dermatology (2014)

Journal Article Most individuals with either segmental or non‐segmental vitiligo display evidence of bilateral cochlear dysfunction Get access T.S. Anbar, T.S. Anbar Dermatology Department Al‐Minya University 129 El‐Hosany street Al‐Minya 61111 Egypt Correspondence Tag S. Anbar. E‐mail: taganbar@yahoo.com Search for other works by this author on: Oxford Academic Google Scholar M.M. El‐Badry, M.M. El‐Badry Audiology Unit ENT Department Al‐Minya University 129 El‐Hosany street Al‐Minya 61111 Egypt Search for other works by this author on: Oxford Academic Google Scholar J.A. McGrath, J.A. McGrath St John's Institute of Dermatology King's College London (Guy's Campus) LondonU.K Search for other works by this author on: Oxford Academic Google Scholar E.S. Abdel‐Azim E.S. Abdel‐Azim Dermatology Department Al‐Minya University 129 El‐Hosany street Al‐Minya 61111 Egypt Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 2, 1 February 2015, Pages 406–411, https://doi.org/10.1111/bjd.13276 Published: 01 February 2015
Faculty Health in Academic Medicine: Physicians, Scientists, and the Pressures of Success
Authors: Larry D. Gruppen
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia
Authors: C Meyer, T Burmeister, S Strehl, B Schneider, D Hubert, O Zach, O Haas, T Klingebiel, T Dingermann, R Marschalek
Journal: Leukemia (2007)
Parasite-stress, cultures of honor, and the emergence of gender bias in purity norms
Authors: Joseph A. Vandello, Vanessa E. Hettinger
Journal: Behavioral and Brain Sciences (2012)

Abstract Of the many far-reaching implications of Fincher &amp; Thornhill's (F&amp;T's) theory, we focus on the consequences of parasite stress for mating strategies, marriage, and the differing roles and restrictions for men and women. In particular, we explain how examination of cultures of honor can provide a theoretical bridge between effects of parasite stress and disproportionate emphasis on female purity.
Splanchnic blood flow in essential hypertension and in hypertensive patients with renal artery stenosis.
Authors: F H Messerli, J Genest, W Nowaczynski, O Kuchel, M Honda, Y Latour, G Dumont
Journal: Circulation (1975)

Splanchnic blood flow (SBF) was measured simultaneously with cardiac output (dye dilution) and intrarterial blood pressure by constant infusion of indocyanine green in 11 control subjects, 13 patients with essential hypertension (EH) and seven hypertensive patients with renal artery stenosis (RAS). The cardiac index (CI) was lower (P less than 0.05) in patients with EH (3.17 plus or minus 0.07 L/min/m-2) (mean plus or minus SEM) than in control subjects (3.43 plus or minus 0.09). Associated with the lower CI was a significantly (P less than 0.01) lower SBF (0.797 plus or minus 0.02 L/min/m-2 vs 0.889 plus or minus 0.04). Patients with RAS presented with higher (P less than 0.01 vs EH, nonsignificant vs control subjects) cardiac index (3.66 plus or minus 0.17) and even lower SBF (0.749 PLUS OR MINUS 0.02). Furthermore, there was a negative correlation (r = - 0.652) between the mean arterial pressure and the SBF when results for all patients were considered. The correlation remained (r = - 0.568) in the EH group and the slope of regression line was not different from that for all subjects. The CI and SBF were weakly correlated (r = 0.423) in control subjects and patients with EH, whereas in patients with RAS, a negative correlation was found (r = - 0.778). This study indicates that the SBF, although significantly decreased in patients with EH, remains proportional to the CI in control subjects and in essential hypertensive patients. No redistribution of CI in regard to the splanchnic circulation occurs in EH. In contrast, in patients with RAS a dissociation of CI and SBF occurs and the fraction of the CI which passes through the splanchnic vascular bed is markedly reduced. The close correlation between mean arterial pressure and SBF suggests that both parameters are influenced by a common pathophysiological factor.
Changes in platelet β‐thromboglobulin, fibrinogen, albumin, 5‐hydroxytryptamine, ATP, and ADP during and after surgery with extracorporeal circulation in man
Authors: Diego Mezzano, Eduardo Aranda, Jorge Urzúa, Guillermo Lema, Jeanette Habash, Manuel J. Irarrázabal, Jaime Pereira
Journal: American Journal of Hematology (1986)

Surgery with extracorporeal circulation (ECC) is associated with transient alterations of platelet function whose pathogenic mechanisms are not completely understood. To define further the platelet abnormalities, we determined the changes in platelet content of several granule-associated substances during and after ECC in patients subjected to aortocoronary bypass surgery. Platelet beta-thromboglobulin (beta-TG) decreased to 79.8% of the preoperative level at the end of ECC (p less than 0.01) and, as expected, did not recover 1 hr after the end of surgery. Platelet fibrinogen and albumin decreased to 67.9% (p less than 0.01) and to 29.8% (p less than 0.01) of baseline, respectively. However, 1 hr after surgery, platelet fibrinogen rose to 92% and albumin to 55.5% of baseline, denoting that during the recovery from ECC, platelets incorporate some plasma proteins. During ECC, platelet 5-hydroxytryptamine (5-HT) and total ATP and ADP decreased to 50.8% (p less than 0.01), 63.2% (p less than 0.01), and 69.9% (p less than 0.01) of their respective preoperative values, indicating dense body release. One hour after surgery, ATP recovered to 83.8%, suggesting that previous depletion compromised also the metabolic pool of adenine nucleotides. In summary, Our results confirm and extend previous observations demonstrating alpha-granule release during ECC. Platelets undergoing ECC can incorporate plasma proteins as evidenced by the rapid increase of platelet fibrinogen and albumin after bypass. Although the mechanisms of this increase and site of storage of the exogenous substances are unknown, this observation justifies further studies to determine if internalization of plasma proteins, especially fibrinogen, may take place in physiological conditions. Dense body depletion with transient storage pool deficiency appears to be a component of the reduced platelet function during ECC. Consumption of metabolic ATP with alteration of platelet energy metabolism may further impair platelet function, contributing to the bleeding episodes observed during surgery with ECC.
Effects of Changes in Fresh Fruit Consumption on Ventilatory Function in Healthy British Adults
Authors: IAIN M. CAREY, DAVID P. STRACHAN, DEREK G. COOK
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Cross-sectional studies have shown frequent fresh fruit consumption to be associated with higher lung function in both children and adults. This relationship is investigated longitudinally in a national sample of 2,171 British adults age 18 to 73 initially examined in 1984, who were reexamined 7 yr later, and had no reported history of chronic respiratory disease throughout. Outcome was assessed by change in forced expiratory volume in one second (FEV1) between the two examinations, standardized for age, height, and sex and related to fresh fruit consumption estimated by food frequency questionnaires at both examinations. After adjustment for region, social class, and smoking, changes in fresh fruit consumption levels were positively associated with changes in FEV1 (p = 0.002), highlighted by a more marked fall in FEV1 (107 ml; 95% confidence interval, 36 to 178 ml) in subjects who reduced their fresh fruit consumption the greatest compared with those with no change. In contrast, average levels of fruit intake were not associated with change in FEV1 (p = 0.695). The implication is that the cross-sectional effects of fresh fruit consumption on ventilatory function appear to be reversible and not progressive, such that consistently low levels of fresh fruit intake do not appear to increase lung function decline.
Syk Tyrosine Kinase Is Required for the Positive Selection of Immature B Cells into the Recirculating B Cell Pool
Authors: Martin Turner, Adam Gulbranson-Judge, Marian E. Quinn, Alice E. Walters, Ian C.M. MacLennan, Victor L.J. Tybulewicz
Journal: The Journal of Experimental Medicine (1997)

The tyrosine kinase Syk has been implicated as a key signal transducer from the B cell antigen receptor (BCR). We show here that mutation of the Syk gene completely blocks the maturation of immature B cells into recirculating cells and stops their entry into B cell follicles. Furthermore, using radiation chimeras we demonstrate that this developmental block is due to the absence of Syk in the B cells themselves. Syk-deficient B cells are shown to have the life span of normal immature B cells. If this is extended by over-expression of Bcl-2, they accumulate in the T zone and red pulp of the spleen in increased numbers, but still fail to mature to become recirculating follicular B cells. Despite this defect in maturation, Syk-deficient B cells were seen to give rise to switched as well as nonswitched splenic plasma cells. Normally only a proportion of immature B cells is recruited into the recirculating pool. Our results suggest that Syk transduces a BCR signal that is absolutely required for the positive selection of immature B cells into the recirculating B cell pool.
Aortic stenosis and gastrointestinal bleeding
Authors: F. Hasan, C. S O'Brien, A. Sanyal, H. R Dalton
Journal: Journal of the Royal Society of Medicine (2004)

Iron deficiency anaemia and calcific aortic stenosis are common findings in elderly patients. Heyde's syndrome, the association of aortic stenosis and gastrointestinal bleeding causing recurrent iron deficiency anaemia, is rare.
TCT-322 Implications Of Human Coronary Autoregulation On Functional Assessment Of Coronary Artery Stenosis Significance Under Baseline Conditions
Authors: Guus A. de Waard, Nicolaas Westerhof, Koen Marques, Ibrahim Danad, Paul F. Teunissen, Maurits Hollander, Paul Knaapen, Niels van Royen
Journal: Journal of the American College of Cardiology (2014)
Benefits and costs of the schools' BCG vaccination programme.
Authors: J A Stilwell
Journal: BMJ (1976)

By the mid-1980s the schools9 BCG vaccination programme will be uneconomic. It is estimated that it will cost about pounds5500 to prevent one case of tuberculosis, the average total cost of which would be between pounds400 and pounds1300 depending on medical policy about the degree of illness for which hospital admission is necessary. In December 1975 the costs of the BCG programme were greater than its monetary benefits, probably by a factor of about 2.
Implications of treating water containing polynuclear aromatic hydrocarbons with chlorine: a gas chromatographic-mass spectrometric study.
Authors: A R Oyler, R J Liukkonen, M K Lukasewycz, D A Cox, D A Peake, R M Carlson
Journal: Environmental Health Perspectives (1982)

The products of aqueous chlorination reactions of 1-methylnaphthalene, fluorene, dibenzofuran, anthracene, phenanthrene, 1-methylphenanthrene, fluoranthene, and pyrene have been determined. The conditions employed for these reactions approximated those that might be encountered in water treatment facilities. Reactions at pH greater than 6 tended to produce oxygenated products (epoxides, phenols, quinones, etc.), and reactions at pH less than 6 tended to produce both oxygenated (quinones) and chlorinated products.
Letter: Airborne lead in Aberystwyth.
Authors: J D Butlen, S D MacMurdo
Journal: BMJ (1974)

virtues of establish.edsimple treatment" (my italics).Bed rest is certainly effective,'0 but when carbenoxolone has been preposed as the "drug of choice" it would be prudent to mention that the drug actually confers no benefit on patients in bed."1As regards smoking, I agree that patients should be advised to stop."When this was done the reduction in ulcer crater size was 83 20/% in patients who stopped smoking and 71 8% in those who did not; it was only 56-6% in those not so advised.Interestingly, the reduotion was 61-3% in non-smokers.-Iam, etc.,