tbuckley/cabot-search huggingface dataset:
Sex differences in hypokalaemic and electrocardiographic effects of inhaled terbutaline.
Authors: A R Rahman, D G McDevitt, A D Struthers, B J Lipworth
Journal: Thorax (1992)

BACKGROUND: Gender differences in the chronotropic effects of infused isoprenaline have previously been described. The aim of the present study was to investigate possible gender differences in hypokalaemic, chronotropic, and electrocardiographic effects of inhaled terbutaline. METHODS: Twenty healthy volunteers (10 female) were recruited (mean age 24 years for women (F) and 22 years for men (M). Subjects were given either inhaled terbutaline 5 mg or placebo in single blind, randomised crossover fashion and the following measurements were made for four hours after inhalation: (a) serum potassium concentration; (b) heart rate; (c) electrocardiographic sequelae (T wave amplitude, Q-Tc interval). The effects of terbutaline on serum potassium was chosen as the primary end point for detecting a 0.3 mmol/l difference between sexes, with a beta error of 0.2 and alpha set at 0.05. RESULTS: The hypokalaemic effects of terbutaline were significantly greater in women, the potassium results (means and 95% CI) being as follows: lowest potassium concentration--F 3.12 (2.96-3.28) mmol/l v M 3.65 (3.49-3.81) mmol/l; percentage change from baseline at one hour--F 15.4% (11.5-19.3%) v M 8.5% (4.6-12.3%); average potassium concentration during the four hours--F 3.39 (3.33-3.46) mmol/l v M 3.78 (3.72-3.85) mmol/l. There was no significant regression between body weight and the potassium response to terbutaline. There were also significant sex differences for T wave, Q-Tc, and heart rate response. The percentage fall in T wave amplitude 30 minutes after terbutaline was: F 44.6% (32.1-57.0%) v M 22.4% (9.9-34.8%). CONCLUSIONS: Women are more sensitive to the hypokalaemic, chronotropic, and electrocardiographic sequelae of inhaled terbutaline.
Assessment of the Efficacy of a Cognitive-Behavioural Group Psychotherapy Programme for HIV-Infected Patients Referred to a Consultation-Liaison Psychiatry Department
Authors: Jordi Blanch, Araceli Rousaud, Martin Hautzinger, Esteban Martínez, Josep-Maria Peri, Susana Andrés, Esteve Cirera, Josep-Maria Gatell, Cristóbal Gastó
Journal: Psychotherapy and Psychosomatics (2002)

&lt;i&gt;Background:&lt;/i&gt; Most HIV-infected patients attending a consultation-liaison psychiatry service show symptoms of anxiety and depression. The present study sought to evaluate the immediate and long-term efficacy of a structured cognitive-behavioural group therapy reducing anxiety and depression in HIV-infected patients referred to a consultation-liaison psychiatry department, and to identify baseline variables predictive of greater improvement. &lt;i&gt;Methods:&lt;/i&gt; Repeated-measures ANOVA was used to analyse changes in the Beck Depression Inventory (BDI) and the state subscale of the State/Trait Anxiety Inventory (STAI) administered to 39 participants at 4 time points: T1 (1 month before beginning the therapy), T2 (during the first session), T3 (during the last session) and T4 (3 months after the last session). The therapy consisted of 16 weekly 2-hour sessions following a structured time-limited cognitive-behavioural group psychotherapy programme. &lt;i&gt;Results:&lt;/i&gt; During the intervention time (between T2 and T3) an improvement was observed in depression and anxiety, which persisted after the 3-month follow-up period (between T3 and T4). No changes were observed during baseline (between T1 and T2). Patients with higher levels of anxiety at baseline showed greater improvement in STAI state subscale scores. Transmission of HIV infection through intravenous drug use was associated with less improvement on the BDI. &lt;i&gt;Conclusions:&lt;/i&gt; This is the first report of an ongoing study which suggests long-lasting efficacy of a structured cognitive-behavioural group psychotherapy programme in a heterogeneous sample of HIV-1-infected patients referred to a consultation-liaison psychiatry unit.
Bradycardia-dependent triggered activity: relevance to drug-induced multiform ventricular tachycardia.
Authors: J Brachmann, B J Scherlag, L V Rosenshtraukh, R Lazzara
Journal: Circulation (1983)

We used cesium chloride (CsCl) for electrophysiologic studies in canine hearts in vivo and in vitro to examine the mechanisms underlying ventricular arrhythmias that are related to prolonged repolarization. Cesium is known to depress normal ventricular automaticity and some experimental arrhythmias by blocking delayed outward currents and prolonging action potential duration. In 10 dogs in normal sinus rhythm, 1 to 1.5 mM/kg iv CsCl prolonged the QT (QU) interval and induced ventricular ectopy in all, including multiform ventricular tachycardia. In 12 dogs with atrioventricular block, 1 to 1.5 mM/kg iv CsCl produced marked suppression of idioventricular rates (from 45 +/- 6 to 8 +/- 4 beats/min). These low rates were then associated with bigeminy or bursts of multiform ventricular arrhythmia. Pacing at rates of 60 beats/min or more suppressed these arrhythmias. Low doses of tetrodotoxin (1 microgram/kg) also abolished these bradycardia-dependent arrhythmias without affecting the amplitude of ventricular electrograms. Tissue concentrations of cesium were determined by anatomic absorption spectroscopy in five dogs after injection of 1 mM/kg CsCl. Thirty minutes after the injection, cesium levels in Purkinje fibers were 5.3 +/- 1.0 mM/kg, levels in ventricular muscle were 4.6 +/- 0.9 mM/kg, and levels in atrial muscle were 4.1 +/- 0.8 mM/kg. In eight isolated endocardial preparations from canine ventricles, standard microelectrode techniques were used to study the effects of superfusion with 5 mM cesium. After 30 min, we observed early afterdepolarizations interrupting phase 3 of Purkinje fiber action potentials that already showed prolonged repolarization. Slowing the rate generated single or multiple action potentials arising from partially repolarized levels of membrane potentials (-80 to -65 mV). Pacing rates of 30 to 60 beats/min diminished the afterdepolarizations and suppressed the spontaneous beats. Tetrodotoxin at a concentration of 10(-8) g/ml, which did not affect upstroke velocity, abolished the afterpotentials. We conclude that cesium induced bradycardia-dependent ventricular arrhythmias caused by early afterdepolarizations. These data suggest that an inward current, probably carried by sodium ions, appears to be essential for the occurrence of this phenomenon. The association of delayed repolarization, afterdepolarizations, and triggered activity has similarities to the phenomenon of drug-induced prolongation of the QTU interval associated with multiform ventricular tachycardia in humans, i.e. "torsades de pointes."
Cardiac Transplantation: Where Are We?
Authors: John Speer Schroeder, Sharon A. Hunt
Journal: New England Journal of Medicine (1986)

In this issue of the Journal, Bailey and his associates document successful short-term survival in three infants who underwent cardiac transplantation for hypoplastic left heart syndrome.1 The authors are to be congratulated for accomplishing this in a group of patients who are difficult to care for postoperatively because of their size and the lack of access for repeated myocardial biopsies to detect allograft rejection. The occurrence of one or more episodes of rejection in all three infants despite immunosuppression with cyclosporine and azathioprine is disappointing, since it had been hoped that a less mature immune system might tolerate a . . .
Society of Homeopaths is censured over misleading claims
Authors: N. Hawkes
Journal: BMJ (2013)

Claims made online by the UK Society of Homeopaths that controversial therapies could treat conditions such as depression breached the advertising code of practice and must not be repeated in their current form, the Advertising Standards Authority has ruled.

The authority found that the claims could discourage people with depression, bronchitis, osteoarthritis, and vertigo from getting medically supervised treatment and that further claims that homeopathy was effective in a range of other conditions were misleading and could not be substantiated.

The authority’s remit was extended to online material in 2011, and since then it has received “a large number of complaints about claims relating to homeopathy that …
Serologic Tests in the Diagnosis of Infectious Diseases
Authors: John C. Ayres, Roy F. Feemster
Journal: New England Journal of Medicine (1950)

Arthropod-Borne Virus Encephalitides and Lymphocytic Choriomeningitis A large group of neurotropic virus infections of man, frequently encountered in epidemic form, are grouped as arthropod-borne virus encephalitides, since the viruses have been isolated from mosquitoes, ticks or mites.62 The following viruses belong to this group: St. Louis, western equine, eastern equine, Venezuelan equine, Japanese B, Russian Far East and louping-ill.Most of the diseases in this group range in severity from the mildest type of illness, which gives no indication of primary involvement of the central nervous system, through a mild febrile meningitic form with spinal-fluid changes and other clinical manifestations, . . .
Noninvasive Assessment of Myocardial Function
Authors: KENNETH I. SHINE, JOSEPH K. PERLOFF, JOHN S. CHILD, ROBERT C. MARSHALL, HEINRICH SCHELBERT
Journal: Annals of Internal Medicine (1980)

Myocardial function can be assessed noninvasively by echocardiography and radionuclide techniques. M-mode echocardiography provides important clues to ventricular volumes, wall thickness, wall motion, ejection fraction, and shortening velocities. The relative movements of posterior wall and septum can be ascertained and several specific cardiomyopathies recognized. M-mode echocardiography gives a limited "ice-pick" view of the left ventricle. Two-dimensional techniques give additional information. Echocardiography is done during rest, while radionuclide procedures are done during rest and exercise. First-pass radionuclide angiocardiography can estimate ventricular ejection fractions independently of geometric assumptions. Equilibrium gated blood pool imaging by multiple gated acquisition techniques allows repeated visual assessment of overall and regional ventricular function. Thallium-201 imaging provides insight into regional myocardial perfusion during rest and exercise but is limited by its resolution and isotope persistence. Newer techniques using 13NH3 promise better approaches to perfusion with tomographic identification of regional changes.
Nuclear factor–κB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis
Authors: Alok C. Bharti, Shishir Shishodia, James M. Reuben, Donna Weber, Raymond Alexanian, Saroj Raj-Vadhan, Zeev Estrov, Moshe Talpaz, Bharat B. Aggarwal
Journal: Blood (2003)
What exactly is central to the role of central neuroplasticity in persistent pain?
Authors: Terence J. Coderre, Joel Katz
Journal: Behavioral and Brain Sciences (1997)

The commentaries on our target article have raised important issues about central neuroplasticity and its role in persistent pain states. Some suggest that central neuroplasticity plays nothing more than a minor role in persistent pain, while others argue that persistent pain depends critically on peripheral inputs for its maintenance. Some stress that persistent pain relies to a large extent on changes in the brain and on centrifugal inputs from brain to spinal cord, whereas others argue that it depends on alterations in inhibitory as well as excitatory systems. We attempt to address each of the commentators' points, while defending our position that central neuroplasticity is critical to pathological persistent pain states.
Insulin-like Signaling Determines Survival during Stress via Posttranscriptional Mechanisms in C. elegans
Authors: Gawain McColl, Aric N. Rogers, Silvestre Alavez, Alan E. Hubbard, Simon Melov, Christopher D. Link, Ashley I. Bush, Pankaj Kapahi, Gordon J. Lithgow
Journal: Cell Metabolism (2010)
Loin percussion in acute pyelonephritis.
Authors: B T Manners
Journal: BMJ (1973)

14 years of age.She was admitted to this hos- pital at 38 weeks' gestation (before the onset of labour) with signs and symptoms suggestive of intra-abdominal haemorrhage.At laparotomy the upper end of the "classical" hysterotomy scar had ruptured completely and a portion of the underlying placenta was protruding through it.There was about 24 1. of fluid and clotted blood in the peritoneal cavity.Caesarian supravaginal hysterectomy was performed and both mother and child survived, but the former required blood transfusions totalling 3 1.
A case of fibro-osseous pseudotumour of the digits
Authors: A. Takahashi, A. Tamura, O. Ishikawa
Journal: British Journal of Dermatology (2001)

Journal Article A case of fibro‐osseous pseudotumour of the digits Get access A. Takahashi, A. Takahashi Department of Dermatology, Gunma University School of Medicine, 3–39–22 Showa‐machi, Maebashi, Gunma 371–8511, JapanE‐mail: ayumit@showa.sb.gunma‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar A. Tamura, A. Tamura Department of Dermatology, Gunma University School of Medicine, 3–39–22 Showa‐machi, Maebashi, Gunma 371–8511, JapanE‐mail: ayumit@showa.sb.gunma‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar O. Ishikawa O. Ishikawa Department of Dermatology, Gunma University School of Medicine, 3–39–22 Showa‐machi, Maebashi, Gunma 371–8511, JapanE‐mail: ayumit@showa.sb.gunma‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 144, Issue 6, 1 June 2001, Pages 1274–1275, https://doi.org/10.1046/j.1365-2133.2001.04255.x Published: 01 June 2001
Ventricular Assist Device Therapy Normalizes Inducible Nitric Oxide Synthase Expression and Reduces Cardiomyocyte Apoptosis in the Failing Human Heart
Authors: Richard D. Patten, David DeNofrio, Mohamad El-Zaru, Rahul Kakkar, Jessica Saunders, Flore Celestin, Kenneth Warner, Hassan Rastegar, Kamal R. Khabbaz, James E. Udelson, Marvin A. Konstam, Richard H. Karas
Journal: Journal of the American College of Cardiology (2005)
Author's Reply: Cancer in Elderly Blacks
Authors: A. Baranovsky, M. H. Myers
Journal: CA A Cancer Journal for Clinicians (1986)

blacks tends to occur at an earlier age and at a more severe stage than in whites.Dif ferences by age in incidence and mortality rates between blacks and whites, starting longbeforeage 65, arevividly presented in a recent publication of the National Can cer Institute: â€oe¿ Cancer among Blacks and Other Minorities: Statistical Profilesâ€•(NIH
The Association between Cardiorespiratory Fitness and Impaired Fasting Glucose and Type 2 Diabetes Mellitus in Men
Authors: Ming Wei
Journal: Annals of Internal Medicine (1999)

Background: Several studies show an inverse association between self-reported physical activity and type 2 diabetes. It is not known whether physical activity or cardiorespiratory fitness is associated with the onset of objectively determined impaired fasting glucose and type 2 diabetes. Objective: To determine whether cardiorespiratory fitness, an objective marker of physical activity, is associated with risk for impaired fasting glucose and type 2 diabetes. Design: Population-based prospective study. Setting: Preventive medicine clinic. Patients: 8633 nondiabetic men (of whom 7511 did not have impaired fasting glucose) who were examined at least twice. Measurements: Cardiorespiratory fitness (determined by a maximal exercise test on a treadmill), fasting plasma glucose level, and other clinical and personal characteristics and incidence of impaired fasting glucose and type 2 diabetes. Results: During an average follow-up of 6 years, 149 patients developed type 2 diabetes and 593 patients developed impaired fasting glucose. After age, cigarette smoking, alcohol consumption, and parental diabetes were considered, men in the low-fitness group (the least fit 20% of the cohort) at baseline had a 1.9-fold risk (95% CI, 1.5- to 2.4-fold) for impaired fasting glucose and a 3.7-fold risk (CI, 2.4- to 5.8-fold) for diabetes compared with those in the high-fitness group (the most fit 40% of the cohort). The risk for impaired fasting glucose was elevated in older men and those with a higher body mass index. Age, body mass index, blood pressure, triglyceride level, and a history of parental diabetes were also directly related to risk for type 2 diabetes. Conclusions: Low cardiorespiratory fitness was associated with increased risk for impaired fasting glucose and type 2 diabetes. A sedentary lifestyle may contribute to the progression from normal fasting glucose to impaired fasting glucose and diabetes. Risk for type 2 diabetes was elevated in older persons and those with higher body mass index, blood pressure, and triglyceride levels and a parental history of diabetes.
Small Molecule Inhibits Defects of Premature Aging Disease
Authors: Tracy Hampton
Journal: JAMA (2014)

A newly identified molecule named Remodelin can effectively treat the damaged nuclei of cells from patients with laminopathies, which include the premature-aging disorder Hutchinson-Gilford progeria syndrome, or HGPS (Larrieu D et al. Science. 2014;344[6183]:527-532).
Serum mast cell tryptase is not a useful marker for disease severity in psoriasis or atopic dermatitis
Authors: S. Gerdes, W. Kurrat, U. Mrowietz
Journal: British Journal of Dermatology (2008)

Severity in psoriasis and atopic dermatitis (AD) is commonly assessed with the Psoriasis Area and Severity Index (PASI) and the SCORing Atopic Dermatitis (SCORAD), respectively. Until today no serum marker is available to reflect the clinical scoring in both diseases. As mast cells play an important role in the pathogenesis of early psoriasis and AD, tryptase, a major compound of mast cell granules that is released upon activation, could in principle serve as such a marker.To assess the correlation between serum tryptase and severity of psoriasis and AD as well as the correlation between total IgE levels and severity of AD.Serum samples from patients hospitalized for psoriasis and AD were collected at time of admission and time of discharge from hospital. PASI and SCORAD assessments were performed at the same time points. Outpatients presenting with naevi and other benign noninflammatory skin lesions served as control group. Serum tryptase values and total IgE levels of patients with AD were measured using a fluoroenzyme immunoassay technique.No correlation of serum tryptase level with either the severity of psoriasis or the severity of AD was seen. Total IgE levels in patients with AD at time of admission and discharge from hospital remained the same.Serum total tryptase did not prove to be a useful tool in assessing severity of psoriasis or AD. Total IgE levels did not correlate with severity of AD.
Abstract 604: Styrene compounds induce apoptosis in triple negative breast cancer cell lines.
Authors: Checo J. Rorie, Shaina L. Richardson, Agape C. Lucas, Phillip A. Thomas, Kashenya M. Gurley, Marion A. Franks
Journal: Cancer Research (2013)

Abstract Triple negative breast cancer (TNBC) is a rare basal-like subtype of breast cancer that is highly aggressive due to its invasiveness and metastatic properties. TNBC is characterized by the loss or low expression of estrogen receptor, progesterone receptor, and HER2 proteins which have been targeted and established as somewhat effective therapy regiments in other breast cancer subtypes including luminal breast cancer. Since triple negative tumors are missing these established drug targets, there has been little advancement in the establishment of drug therapies to specifically target this breast cancer subtype and therefore the need for novel therapeutics in treating TNBC still remains. Previous reports have suggested that PARP inhibitors show promise in potentiating the effectiveness of other known chemotherapeutics. Styrene compounds are volatile organic compounds that have a similar structural composition to some known PARP inhibitors. Our group has developed styrene compounds composed of a 3-nitro group on the A ring and varying aryl groups in the B ring of the styrene, and then tested their biological effects on luminal and TNBC cell lines. In this study, four different styrene compounds were used to treat the luminal breast cancer cell line HCC70 and the triple negative breast cancer cell line HCC1806. The breast cancer cells were exposed to a 10, 100, and 1000 μM titration over a 24hr time period. The apoptotic effect on these cell lines were analyzed and measured via qualitative and quantitative methods. We show here that light microscopy revealed a classic apoptotic dose-response to all of the styrene compounds in the cell lines. We also used the cell viability and MTT assays to reveal a dose-response decrease in cell viability and increase in cell death to the titration of the styrene compounds. This preliminary data show that these compounds have the ability to induce apoptosis in luminal and triple negative breast cancer cell lines. Our preliminary results lead us to believe that these styrenes could represent a new chemotherapeutic treatment for Triple Negative Breast Cancer and potentially other breast cancer subtypes. Citation Format: Checo J. Rorie, Shaina L. Richardson, Agape C. Lucas, Phillip A. Thomas, Kashenya M. Gurley, Marion A. Franks. Styrene compounds induce apoptosis in triple negative breast cancer cell lines. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 604. doi:10.1158/1538-7445.AM2013-604
The genome of the cucumber, Cucumis sativus L.
Authors: Sanwen Huang, Ruiqiang Li, Zhonghua Zhang, Li Li, Xingfang Gu, Wei Fan, William J Lucas, Xiaowu Wang, Bingyan Xie, Peixiang Ni, Yuanyuan Ren, Hongmei Zhu, Jun Li, Kui Lin, Weiwei Jin, Zhangjun Fei, Guangcun Li, Jack Staub, Andrzej Kilian, Edwin A G van der Vossen, Yang Wu, Jie Guo, Jun He, Zhiqi Jia, Yi Ren, Geng Tian, Yao Lu, Jue Ruan, Wubin Qian, Mingwei Wang, Quanfei Huang, Bo Li, Zhaoling Xuan, Jianjun Cao, None Asan, Zhigang Wu, Juanbin Zhang, Qingle Cai, Yinqi Bai, Bowen Zhao, Yonghua Han, Ying Li, Xuefeng Li, Shenhao Wang, Qiuxiang Shi, Shiqiang Liu, Won Kyong Cho, Jae-Yean Kim, Yong Xu, Katarzyna Heller-Uszynska, Han Miao, Zhouchao Cheng, Shengping Zhang, Jian Wu, Yuhong Yang, Houxiang Kang, Man Li, Huiqing Liang, Xiaoli Ren, Zhongbin Shi, Ming Wen, Min Jian, Hailong Yang, Guojie Zhang, Zhentao Yang, Rui Chen, Shifang Liu, Jianwen Li, Lijia Ma, Hui Liu, Yan Zhou, Jing Zhao, Xiaodong Fang, Guoqing Li, Lin Fang, Yingrui Li, Dongyuan Liu, Hongkun Zheng, Yong Zhang, Nan Qin, Zhuo Li, Guohua Yang, Shuang Yang, Lars Bolund, Karsten Kristiansen, Hancheng Zheng, Shaochuan Li, Xiuqing Zhang, Huanming Yang, Jian Wang, Rifei Sun, Baoxi Zhang, Shuzhi Jiang, Jun Wang, Yongchen Du, Songgang Li
Journal: Nature Genetics (2009)
TCT-551 Randomized Comparison of Flow Reversal vs Distal Filter for Cerebral Protection During Carotid Artery Stenting in Patients With Stable Carotid Disease
Authors: Andrea Pacchioni, Antonio Mugnolo, Sepideh Torabi Parizi, Francesco Versaci, Salvatore Saccà, Riccardo Turri, Bernhard Reimers
Journal: Journal of the American College of Cardiology (2014)