tbuckley/cabot-search huggingface dataset:
APPLICATION OF SULFONAMIDE SOLUTIONS TO NOSE
Authors: Walter D. Klestadt
Journal: JAMA (1942)

<h3>To the Editor:—</h3> Dr. Russell Fletcher (The Journal, Oct. 4, 1941, p. 1204) has cautioned against the local application of sulfonamide drugs on chronically inflamed sinuses. His view is based on his own experience with an unusual case of odontogenous antritis and also on an opinion by Dr. M. L. Tainter, a pharmacologist, who stressed the caustic action of these drugs and ascribed this effect to their alkalinity. Briefly, Dr. Fletcher's case revealed an extremely foul exudate emanating from a fistulous tract in the mouth. Osteomyelitis in the vicinity of the tooth socket was present with loosening of the adjacent tooth. Frequent irrigations of the usual kind were of no avail and the use of 5 to 10 per cent sodium sulfathiazole in physiologic solution of sodium chloride —according to the procedure of Dr. F. M. Turnbull of Los Angeles—was instituted. However, surgical intervention finally had to be instituted and
Exercise training reduces serum capacity to induce endothelial cell death in patients with chronic heart failure
Authors: Caterina Mammi, Andrea la Sala, Maurizio Volterrani, Lucia Gatta, Antonella Antelmi, Alessandra Feraco, Giuseppe Caminiti, Giuseppe Marazzi, Cristiana Vitale, Massimiliano Caprio, Giuseppe Massimo Claudio Rosano
Journal: European Journal of Heart Failure (2011)
Two Cases of Favism in Israel
Authors: S. Mansoor
Journal: BMJ (1955)

Phage-typing was carried out orn some of the cultured strains by the Staphylococcal Reference Laboratory, Colin- dale.This showed that staphylococci with different sensi- tivity patterns were of different phage types and that those with the same patterns were of the same phage types (Table III).That there is a close analogy between phage TABLE III.-Phage Patterns of Staphylococci Obtained from the Nursing Staff (A, B, C), the Infected Wounds (D), and the Surgeon (E and F) Phage A B C |D
The ongoing H1N1 flu pandemic and the intensive care community: challenges, opportunities, and the duties of scientific societies and intensivists
Authors: Rui P. Moreno, Andrew Rhodes, Jean-Daniel Chiche
Journal: Intensive Care Medicine (2009)

This year has brought a new challenge to Intensive Care Medicine. The current influenza A (H1N1) pandemic may have a disproportionate effect on the provision of Intensive Care services in Europe. These challenges cause many anxieties for practicing clinicians, both as to what to expect, how to practice and what support or help they will be given. In this statement from the European Society of Intensive Care Medicine (ESICM), we aim to describe some of the facts, the fears and the areas where scientific societies can help to improve our understanding of these problems and at the same time reduce the impact of these issues for our members and their patients.
Protection of Mice by Interferon Against Systemic Virus Infections
Authors: N. B. Finter
Journal: BMJ (1964)

not known.It is conceivable that the heat from the placenta on the anterior wall of a uterus might soak through a thin abdominal wall, but it is difficult to understand how thermal contours were altered by a placenta situated upon the posterior uterine wall of an obese patient with hydramnios as in Case 2. The radiator effect of the umbilicus has been mentioned, but this question remains open and is the subject of further investi- gation.It is just possible that the vasomotor nervous system is involved to a large extent. SummaryThe problems of placental localization and other applications of thermography are reviewed briefly to indicate the rationale of a trial of the Pyroscan and its theoretical advantages.Cases were selected for thermographic study upon their liability to be delivered per abdomen.From 47 cases studied 13 came to section and the accuracy of predictions is assessed and discussed.A basic description of the Pyroscan is given, and experimental methods and conditions are described.Interpretation of thermographs of the pregnant abdomen is discussed with reference to the thermal contours of non- pregnant controls.The results showed that the site of functional placental tissue could be accurately predicted in one plane in all the cases that came to section.
Case clustering in pityriasis rosea: support for role of an infective agent.
Authors: A G Messenger, E G Knox, R Summerly, H L Muston, E Ilderton
Journal: BMJ (1982)

One hundred and twenty-six cases of pityriasis rosea seen over two years in north Staffordshire were analysed for clustering in time and space. A statistically significant degree of clustering was found; this was evident among female patients considered separately but not among male patients. The incidence of the condition was higher in patients working in, or attending, educational establishments. These findings support the hypothesis that pityriasis rosea is caused by an infective agent. A search for an infective organism and a transmission mechanism now seems justifiable.
Design of a Phase 2 STudy of Brentuximab Vedotin (SGN-35) as Salvage Therapy for Males with Chemoresistant Germ-Cell Tumors (GCT)
Authors: P. Giannatempo, A. Anichini, D. Raggi, E. Cordareschi, N. Nicolai, M. Colecchia, R. Salvioni, P. Valagussa, A. Gianni, A. Necchi
Journal: Annals of Oncology (2014)
Health Care in America: An Intimate Glimpse
Authors: James F. Ganem
Journal: Annals of Internal Medicine (1997)

Letters1 June 1997Health Care in America: An Intimate GlimpseJames F. Ganem, MDJames F. Ganem, MDEast Valley Cardiology, Chandler, AZ 85224Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-11-199706010-00034 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I started reading Byron Farwell's essay [1] with the hope of finding ways to more compassionately care for my patients, but by the end of the essay I had even greater concern about the growing irresponsibility of the elderly.Mr. Farwell, in the 30 years since you were sipping cognac during your hospitalization and surgery, much has happened to the financing of health care in the United States. This has primarily been brought on by the unwillingness of the Medicare population to pay for even part of their health care. The care you received during your hospitalization ...REFERENCE1. Farwell B. Health care in America: an intimate glimpse. Ann Intern Med. 1996; 125:1005-6. Google Scholar Author, Article, and Disclosure InformationAuthors: James F. Ganem, MDAffiliations: East Valley Cardiology, Chandler, AZ 85224 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1997Volume 126, Issue 11Page: 922KeywordsDiagnosis related groupsElderlyHealth careHealth care qualityHealth maintenance organizationsHospitalizationsMedicareMotivationPatientsSurgery ePublished: 15 August 2000 Issue Published: 1 June 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Excess Body Weight Is Not Independently Associated with Outcome in Mechanically Ventilated Patients with Acute Lung Injury
Authors: James M. O'Brien, Carolyn H. Welsh, Ronald H. Fish, Marek Ancukiewicz, Andrew M. Kramer
Journal: Annals of Internal Medicine (2004)

Background: Despite an epidemic of obesity among adults, the effect of excess body weight on outcome from critical illness is not well studied. Objective: To examine the association between excess body weight and outcome in mechanically ventilated patients with acute lung injury. Design: Secondary analysis of participants in trials of therapy for acute lung injury. Setting: 10 U.S. medical centers that participate in the National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network. Patients: 902 mechanically ventilated patients who were enrolled in randomized, controlled trials of therapy for acute lung injury. Intervention: Assignment to higher (12 mL/kg of predicted weight) or lower (6 mL/kg of predicted weight) tidal volume ventilation strategies with specified weaning protocols. Some patients also received ketoconazole, lisofylline, or placebo by factorial design. Measurements: Mortality rate, rate of unassisted ventilation by day 28, and number of ventilator-free days. Results: Indirect causes of lung injury, including trauma, were more common in obese patients. Overweight and obese patients had higher peak and plateau airway pressures before enrollment because of higher set tidal volumes. After risk adjustment, excess body weight was not associated with death, achievement of unassisted ventilation, or number of ventilator-free days. This lack of effect persisted with categorical or continuous measures of body mass index (BMI). We found no significant interaction between ventilator protocol assignment and BMI category. Conclusions: After risk adjustment, overweight and obese patients with acute lung injury have outcomes similar to those of patients with normal BMI. The lack of interaction between ventilator protocol assignment and BMI suggests that patients with normal, overweight, or obese BMI benefit from lower tidal volume ventilation for acute lung injury. *For members of the National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network, see the Appendix.
Symbiotic bacteria are responsible for diet-induced mating preference in<i>Drosophila melanogaster</i>, providing support for the hologenome concept of evolution
Authors: Gil Sharon, Daniel Segal, Ilana Zilber-Rosenberg, Eugene Rosenberg
Journal: Gut Microbes (2011)

Diet-induced mating preference in Drosophila melanogaster results from amplification of the commensal bacterium Lactobacillus plantarum, providing a new role for gut microbiota and support for the hologenome concept of evolution. When the flies were treated with antibiotics prior to changing their diet, mating preference did not occur. These data also indicate that other potentially beneficial bacteria could be irreversibly lost by antibiotic treatment and that their replacement could provide a health benefit. We suggest that D. melanogaster can be a useful model organism to study the activities of gut microbiota and their interaction with the immune system.
Allergic Complications of Meningococcal Disease II--Immunological Investigations
Authors: B. M. Greenwood, H. C. Whittle, A. D. M. Bryceson
Journal: BMJ (1973)

Immunological investigation of four patients with meningococcal meningitis who developed arthritis or cutaneous lesions showed circulating meningococcal antigen at the time of presentation in each patient. It was cleared from the circulation over the next few days. Circulating antibody was detectable in three of the four patients about a week after the onset of the illness. A marked fall in the serum C(3) level occurred in two patients at about that time. Deposits of meningococcal antigen, immunoglobulin, and C(3) were detected in the synovial fluid white cells of the two patients studied and in one of three skin biopsies examined. These findings suggest that the arthritis and cutaneous lesions of meningococcal meningitis may be due to immune complex formation.
Flow cytometric analysis and sorting of HLA-DR+CD1+ Langerhans cells
Authors: J. ASHWORTH, M.C. KAHAN, S.M. BREATHNACH
Journal: British Journal of Dermatology (1989)

There is a considerable need for reliable methods for enumeration and enrichment of Langerhans cells (LCs), since they continue to be the subject of intensive investigation in normal and diseased skin. It has been claimed that standard labelling with either anti‐HLA‐DR or OKT6 antibodies alone may fail to identify potentially important subsets of LCs with the phenotypes HLA‐DR+CD1− and HLA‐DR−CD1+. We report here on flow cytometric analysis of suction blister‐derived normal epidermal cell (EC) suspensions, double stained with phycoerythrin‐conjugated anti‐HLA‐DR and fluoresceinated OKT6. In seven separate experiments, no evidence for the existence of either HLA‐DR+CD1− or HLA‐DR−CD1+ECs was obtained. We found that HLA‐DR+CD1+LCs, which constituted a mean of 2.5% (±0.3 SEM) of all ECs, could be readily identified on the basis of fluorescence, and that their light scatter characteristics were those of moderately sized cells of low granularity. We further describe our method for flow cytometric enrichment of such HLA‐DR+CD1+ LCs for functional studies, based on selection on both fluorescence and light scatter criteria. Enrichment is to greater than 90% purity, and the method is applicable to the small number of ECs (approximately 1 × 106) obtained from a suction blister.
Stratified cluster sampling
Authors: P. Sedgwick
Journal: BMJ (2013)

Researchers investigated the suitability of a newly developed famine scale as an international definition of famine to guide humanitarian response, funding, and accountability.1 The scale had been proposed by Howe and Devereux, and it defined famine on the basis of intensity and magnitude . 2 The scale was applied retrospectively to the humanitarian crisis during 2005 in Niger, west Africa, to determine whether famine had occurred. A cross sectional study design was used. Households were recruited using a stratified two stage cluster sampling method. Niger was stratified into its eight regions. Within each region, 26 villages were randomly selected, with the probability of selection proportional to the size of the village. Within each village, 20 households were systematically randomly selected. A census of the entire household was undertaken by administering a questionnaire to the head of each selected household. The researchers concluded that on the basis of the famine scale developed by Howe and Devereux, most regions in Niger in 2005 experienced food crisis conditions, and some areas approached famine. Furthermore, it was suggested that the scale afforded more objective criteria than did previous approaches while providing early warning systems that might help guide the level of response in future situations. Which of the following statements, if any, are true?
Tilt table testing for assessing syncope
Authors: David G. Benditt, David W. Ferguson, Blair P. Grubb, Wishwa N. Kapoor, John Kugler, Bruce B. Lerman, James D. Maloney, Antonio Ravielle, Bertrand Ross, Richard Sutton, Michael J. Wolk, Douglas L. Wood
Journal: Journal of the American College of Cardiology (1996)
Matrix Metalloproteinase 26 Proteolysis of the NH2-Terminal Domain of the Estrogen Receptor β Correlates with the Survival of Breast Cancer Patients
Authors: Alexei Y. Savinov, Albert G. Remacle, Vladislav S. Golubkov, Maryla Krajewska, Susan Kennedy, Michael J. Duffy, Dmitri V. Rozanov, Stan Krajewski, Alex Y. Strongin
Journal: Cancer Research (2006)

Estrogens have many cellular functions, including their interactions with estrogen receptors alpha and beta (ERalpha and ERbeta). Earlier, we determined that the estrogen-ER complex stimulates the transcriptional activity of the matrix metalloproteinase 26 (MMP-26) gene promoter. We then determined that ERbeta is susceptible to MMP-26 proteolysis whereas ERalpha is resistant to the protease. MMP-26 targets the NH(2)-terminal region of ERbeta coding for the divergent NH(2)-terminal A/B domain that is responsible for the ligand-independent transactivation function. As a result, MMP-26 proteolysis generates the COOH-terminal fragments of ERbeta. Immunohistochemical analysis of tissue microarrays derived from 121 cancer patients corroborated these data and revealed an inverse correlation between the ERalpha-dependent expression of MMP-26 and the levels of the intact ERbeta in breast carcinomas. MMP-26 is not expressed in normal mammary epithelium. The levels of MMP-26 are strongly up-regulated in ductal carcinoma in situ (DCIS). In the course of further disease progression through stages I to III, the expression of MMP-26 decreases. In contrast to many tumor-promoting MMPs, the expression of MMP-26 in DCIS correlated with a longer patient survival. Our data suggest the existence of an MMP-26-mediated intracellular pathway that targets ERbeta and that MMP-26, a novel and valuable cancer marker, contributes favorably to the survival of the ERalpha/beta-positive cohort of breast cancer patients.
Stress Electrocardiography in the Evaluation of Surgical Revascularization of the Heart
Authors: DONALD G. KASSEBAUM, MELVIN P. JUDKINS, HERBERT E. GRISWOLD
Journal: Circulation (1969)

Electrocardiography was carried out during hypoxemia and graded exercise tests before and at intervals between 2 and 20 months after attempts to revascularize the heart by internal mammary artery implantation in 44 patients with angiographically documented coronary disease and angina pectoris. Eleven patients had single vessel disease; the right coronary was involved in seven of these patients. Thirteen patients had single vessel implants, employing the left internal mammary artery in 11 patients and a saphenous vein graft from the aorta in two. Thirty-one patients had double internal mammary artery implantation accompanied by gastroepiploic arterial implantation in four. Fifty per cent of the patients were symptomatically improved after surgery, the best results occurring in two patients with isolated anterior descending coronary disease. Of the 34 patients having postoperative coronary and mammary arteriography, 15% showed improvement which could be ascribed to mammary revascularization; 24% had limited myocardial revascularization and no symptomatic improvement; 29% had patent implants without development of collateral vessels, and the implanted vessels were occluded in 32%. Eleven of the 34 (32%) had fair or good symptomatic improvement in the absence of revascularization. The results of postoperative stress electrocardiography correlated closely with the findings on postoperative coronary and mammary angiography. The stress tests were persistently positive after operation in 83% of the patients having angiographically confirmed implant occlusion or nonrevascularization. The stress ECG response was reversed, becoming negative postoperatively, in five cases of angiographically proved significant revascularization. Thus, stress electrocardiography provided objective evidence of improvement in a small number of patients with limited coronary disease who developed good collateral circulation and correlated with the lack of revascularization in the majority even in those subjectively improved.
Amputation in Senile Gangrene
Authors: N. C. Dobson
Journal: BMJ (1882)

WITH reference to amputation in senile gangrene, nearly all authorities agree that it is not wise to undertake the operation; it therefore re- quires some courage and some convictions to'justify any surgeon in advocating a course which is in opposition to generally received opinion.The case which I shall presently narrate, and in which I amputated with most gratifying success, with other cases I have seen, must afford my justification for the line of treatment I consider advisable under certain circumistances in cases of senile gangrene.It is true that, from time to time, surgeons have recommended amputation, and notably the late Mr. James of Exeter; but, even when they have done so, it does not appear that any very precise directions have been given for the guidance of those who may wish to follow such recommenda- tion.
GENETIC INFLUENCE ON THE RENIN-ANGIOTENSIN SYSTEM
Authors: Junichi Iwai, Knud D. Knudsen, Lewis K. Dahl
Journal: The Journal of Experimental Medicine (1970)

TWO STRAINS OF RATS WITH OPPOSITE GENETIC PROPENSITY FOR HYPERTENSION WERE TESTED FOR: (a) the sensitivity to injections of angiotensin and renin, and (b) the influence of their plasma on the reaction velocity of renin and its substrate in vitro. Intact hypertension-prone (S) rats on low salt had higher sensitivity to angiotensin and a lower sensitivity to renin than hypertension-resistant (R) rats. High NaCl diet did not change the response of the R rats to these injections, but increased the response to renin and angiotensin in intact S rats. Bilateral nephrectomy caused increased response to renin and a decreased response to angiotensin in the S rats, so that both strains were equivalent after bilateral nephrectomy. In vitro, plasma from intact S rats inhibited the activity of hog renin. Plasma from R rats showed no inhibition. The inhibitor disappeared after bilateral nephrectomy. It was speculated that renin inhibitor may be involved in the development of hypertension by increasing sensitivity to angiotensin and other hypertensinogenic stimuli.
Diseases of the Skin. An Outline of the Principles and Practice of Dermatology.
Authors: Malcolm Alexander Morris
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
DIAGNOSTIC VALUE OF INDEX OF MICROCIRCULATORY RESISTANCE FOR DETECTION OF MICROCIRCULATORY DAMAGE EARLY AFTER ANTERIOR VERSUS NON-ANTERIOR MYOCARDIAL INFARCTION
Authors: Masashi Fukunaga, Kenichi Fujii, Daizo Kawasaki, Hisashi Sawada, Tsuyoshi Nakata, Toshihiro Iwasaku, Hirokuni Akahori, Motomaru Masutani, Masaaki Lee Kawabata, Mitsumasa Ohyanagi, Tohru Masuyama
Journal: Journal of the American College of Cardiology (2011)
Effects of arsenic cell metabolism and cell proliferation: cytogenetic and biochemical studies.
Authors: J Petres, D Baron, M Hagedorn
Journal: Environmental Health Perspectives (1977)

Chromosome analysis of lymphocytes from patients who had been exposed to arsenic showed frequent structural and numerical aberrations, even with an interval of decades since the last exposure. The in vitro addition of sodium arsenate induced the same chromosome changes--even to extreme of chromosome pulverizations--upon lymphocyte cultures from healthy subjects. Radioactive incorporation studies showed that arsenate was able to inhibit dose-dependently the incorporation of radioactively labeled nucleotide in RNA and DNA. Beyond that, arsenic blocked the cells in the S- and G2-phase. A general explanation for the inhibitory effect of inorganic arsenic on cell metabolism is the known strong affinity of arsenic to enzymes, especially to those containing sulfhydryl groups.
An ABC of Prescribing Sins
Authors: M E Molyneaux
Journal: BMJ (1980)

With which drugs are let loose on the public.Failure to give due care and consideration to the use of drugs leads to most of the other sins (B-Z).Uncritical use of the latest fashions often leads to inappropriate, dangerous, or expensive prescribing. GULLIBILITY HIGH-HANDEDNESS CHARITY, MISGUIDED DIE-HARD PRESCRIBING HABITS EXTRAVAGANCEBy which developing countries are bombarded with cast-off drugs that are out of date, undated, irrelevant to local diseases, or all of these.Which persist despite the accumulation of evidence that they are valueless.Failure to consider cost when pre- scribing may mean that the budget for vital, much-needed drugs is exhausted sooner than necessary.