Water Intoxication and Thioridazine (Mellaril®)
Authors: K. J. RAO
Journal: Annals of Internal Medicine (1975)

Letters1 January 1975Water Intoxication and Thioridazine (Mellaril®)K. J. RAO, M.D., MYRON MILLER, M.D., ARNOLD MOSES, M.D.K. J. RAO, M.D., MYRON MILLER, M.D., ARNOLD MOSES, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-1-61_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe occurrence of water intoxication in patients who have the ability to dilute urine normally is very unusual (1). Normal adults can excrete between 10 and 14 ml/min of solute-free water, and it is an unusual circumstance which results in the ingestion of sufficiently more water than this so that significant dilutional hyponatremia develops. We wish to report two cases of patients we have recently observed, both of whom had a psychiatric background and who were being treated with thioridazine (Mellaril®) at the time of the water intoxication. The first patient was a 51-year-old man admitted to the hospital because...References1. LANGGARDSMITH HW: Self-induced water intoxication without predisposing illness. N Engl J Med 266:378-381, 1962 CrossrefMedlineGoogle Scholar2. NIELSEN J: Water intoxication and psychosis (letter). Ann Intern Med 80:280-281, 1974 Google Scholar3. DEMANETBONNYNSBLEIBERG JMH: Coma due to water intoxication in beer drinkers. Lancet 2:1115-1117, 1971 CrossrefMedlineGoogle Scholar4. GARCIAMILLERMOSES MMA: Chlorpropamide-induced water retention in patients with diabetes mellitus. Ann Intern Med 75:549-554, 1971 LinkGoogle Scholar5. ROSENTHALKAUFMAN SS: Vincristine neurotoxicity. Ann Intern Med 80:733-737, 1974 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Administration Hospital Irving Avenue and University Place Syracuse, New York 13210Department of Medicine State University of New York Upstate Medical Center Syracuse, New York 13210 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNeuroleptic drugsThioridazineDisorders of Sodium and Water BalanceDiabetes insipidus and other polyuric syndromesHyponatremia Induced by DrugsAntipsychotic-Induced HyponatraemiaNEUROLEPTIC DRUGSENDOCRINE AND METABOLIC ADVERSE EFFECTS OF NON-HORMONAL AND NON-METABOLIC DRUGSDiabetes insipidus and other polyuric syndromesA Review of Drug-Induced HyponatremiaPsychogenic polydipsia review: Etiology, differential, and treatmentNeuroleptic drugsThioridazinePIP syndrome: A potentially threatening manifestation of a psychiatric disorderNeuroleptic induced polydipsia and hyperphagia in an adult with learning disabilityA Review of Disorders of Water Homeostasis in Psychiatric PatientsLong-term neurologic outcome in psychogenic water drinkers with severe symptomatic hyponatremia: The effect of rapid correctionPolydipsia in the chronically mentally ill: A reviewPolydipsia and Hyponatremia Induced by Multiple Neuroleptics but Not MolindoneDiagnosis and Management of HyponatremiaManners of Arginine Vasopressin Secretion in Schizophrenic Patients:—With Reference to the Mechanism of Water Intoxication—Long-Term Neuroleptic Toxicity and Mood: Blurring of Diagnostic BoundariesSIADH: A Serious Side Effect of Psychotropic DrugsDrug Management of Antidiuretic Hormone Imbalance following Pituitary SurgeryTHE CLINICAL EVALUATION OF SEIZURESSyndrome of Inappropriate Secretion of Anti-Diuretic Hormone in a Patient Treated with HaloperidolWasserintoxikation und Hirn�dem bei psychogener PolydipsieAntidiuretic Hormone Syndrome and ThioridazineFREDERICK M. VINCENT, M.D., SCOTT EMERY, M.D.Water MetabolismDrug-induced states of impaired water excretionPathophysiologic and pharmacologic alterations in the release and action of ADH 1 January 1975Volume 82, Issue 1Page: 61-61KeywordsHyponatremiaIngestionIntoxicationUrine Issue Published: 1 January 1975 PDF DownloadLoading ...