tbuckley/cabot-search huggingface dataset:
Radio-opaque punctate opacities on the chest radiograph following intravenous injection of a bismuth compound
Authors: D. J. Addrizzo-Harris, A. Churg, W. N. Rom
Journal: Thorax (1997)

The case history is described of a patient who presented with small rounded punctate metallic opacities widely dispersed on the chest radiograph with accumulation of metallic particles in the right ventricle. Energy dispersive x ray spectroscopy of alveolar macrophages identified a major predominant peak as bismuth. The patient had been injected with a health tonic in Honduras two years earlier.
The Role of Trauma in Oncogenesis: A Juridical Consideration
Authors: Lionel Sandler Auster
Journal: JAMA (1961)

Lawsuits based on the contention that cancer resulted from a single injury are frequent. The possibility that trauma may call attention to an existing tumor rather than causing it is often disregarded, and justice is often thwarted by forensic oratory. The most dramatic injuries in litigation are fractures. The court should be advised that falls are more often the result than the cause of a pathological fracture through an area of neoplastic involvement. The criteria developed by Ewing and others, here outlined, have medical acceptance and are gaining legal acceptance as a result of decisions by appellate courts. Impartial panels of experts capable of delivering scientifically valid testimony in cases of alleged negligence have already helped in the search for truth.
Nine in 10 articles rejected by NEJM appear in another journal
Authors: T. Groves
Journal: BMJ (2009)

The results of a study to determine what proportion of papers rejected by the New England Journal of Medicine eventually get published elsewhere were presented at an international conference in Vancouver last week.

Reporting their findings at the sixth international congress on peer review and biomedical publication in Vancouver on 11 September, Michael Bretthauer and colleagues from NEJM explained how they identified all research papers that the journal rejected in two years, 1995 and 2003, from their databases and then searched for them in the PubMed bibliographic search engine during 2008-9.

In 1995 1431 papers were rejected after peer review, of which 1273 (89%) had been published by 2009, …
Plasma clearance of human extracellular-superoxide dismutase C in rabbits.
Authors: K Karlsson, S L Marklund
Journal: Journal of Clinical Investigation (1988)

Extracellular-superoxide dismutase (EC-SOD) is heterogenous in the vasculature with regard to heparin affinity and can be separated into three fractions: A, without affinity; B, with weak affinity; and C, with relatively strong heparin affinity. The plasma clearance of intravenously injected 125I-labeled and unlabeled human EC-SOD C was studied in rabbits. About 90% of injected 125I-EC-SOD C was eliminated from the blood within 5-10 min. Injection of heparin after 10 or 20 min led to an immediate release of all sequestered 125I-EC-SOD C back to the blood plasma. Later injections of heparin led to diminished release, although release could still be demonstrated after 72 h. A half-time of approximately 10 h could be calculated for heparin-releasable 125I-EC-SOD C. Unlabeled EC-SOD C, determined as enzymic activity and with ELISA, was likewise sequestered and released to the same degree as 125I-labeled EC-SOD C by heparin as tested at 20 min and 5 h. The immediacy of the heparin-induced release indicates that the sequestered enzyme had been bound to endothelial cell surfaces. The length of the half-time suggests that the putative cell surface binding has a physiological function and is not primarily a step in enzyme degradation. The distribution of sequestered 125I-labeled EC-SOD C to different organs was determined at times between 10 min and 24 h. Of the organs, the liver contained the most 125I-EC-SOD C, followed by kidney, spleen, heart, and lung. At all investigated times, the content in the analyzed organs was nearly as large as the amount that could be promptly released to plasma by intravenous heparin. This indicates that almost all 125I-EC-SOD C in the organs was present on endothelial cell surfaces and was not bound by other tissue cell surfaces, or was present within the cells.
Evidence of right ventricular remodeling after primary stenting for acute myocardial infarction: A cine magnetic resonance imaging study
Authors: Farzin Beygui, Alain Furber, Stephane Delépine, Gérard Helft, Claude Le Feuvre, Philippe Geslin, Jean Phillipe Metzger, Jean Jacques Le Jeune, Pitié-Salp etrière
Journal: Journal of the American College of Cardiology (2003)
USE OF EX VIVO CRYOIMAGING AS AN ADJUVANT FOR PLAQUE VALIDATION BY OPTICAL COHERENCE TOMOGRAPHY AND FOR CHARACTERIZATION OF FIBROUS CAP INFLAMMATION IN ATHEROSCLEROTIC PLAQUES
Authors: Ali Faramarzalian, David Prabhu, Ahmad Abdul–Aziz, Daniel Chamie, Hirosada Yamamoto, Yusuke Fujino, Wei Wang, Nicholas Ziats, Andrew Rollins, David Wilson, Marco Costa, Hiram Bezerra
Journal: Journal of the American College of Cardiology (2013)
Anti-inflammatory and Analgesic Properties of Thiabendazole
Authors: William C. Campbell
Journal: JAMA (1971)

<h3>To the Editor.—</h3> The first trials of thiabendazole in the treatment of trichinosis in man resulted either in dramatic clinical improvement and apparent cure<sup>1,2</sup>or at least in a rapid subsidence of the signs and symptoms of the disease.<sup>3</sup>In comparison with the rather intensive therapy needed to kill trichinae in laboratory animals, the dosage used in those early trials seemed modest, and the response correspondingly surprising. Additional clinical trials of thiabendazole in patients with trichinosis showed that defervescence and subjective clinical improvement often occur even though live larvae may be found upon subsequent biopsy.<sup>4</sup>This clinical response might be attributed to the death of a proportion of the larvae present in the muscles (a result difficult to demonstrate by biopsy procedures). Alternatively, it might be attributed to an interruption in the secretion of toxic materials by live, but drug-affected, larvae. Occasionally, however, clinicians have wondered whether
A Physician's Directory.
Authors: John T. Cahill.
Journal: JAMA (1902)

Lawrence, Mass., Feb. 3, 1902. <h3>To the Editor:</h3> —I am of the opinion that a step in the right direction may be taken by establishing a system of registration followed by the publication of a "Physician's Directory" by the American Medical Association. The great danger to the medical profession is not from the quack or the promoter of a fad, but from him who has obtained a medical degree, secured a state license, perhaps has been admitted to the state society, and has been unable morally to keep up with the respectable members of the profession. Such an individual sooner or later is found out and can be easily cared for. The great majority of immoral and ignorant of those who have received medical degrees and state license do not seek admission to societies because they fear the required examination and the discussion of medical topics by regular physicians. This
Antithrombin III deficiency, hypertriglyceridaemia, and venous thromboses.
Authors: O H Gyde, M D Middleton, G R Vaughan, D J Fletcher
Journal: BMJ (1978)

limbs cause great discomfort for the child, further difficulties in management (especially lifting), and time lost from school.Conven- tional conservative measures to splint the limb are usually inappro- priate, as reduction in joint mobility prevents manipulation of the limb without excessive pain.Here we describe a method for over- coming some of the difficulties in splinting limbs.
THE COUNCIL ON PHYSICAL THERAPY
Authors: Richard Kovacs
Journal: JAMA (1927)

<h3>To the Editor:</h3> —At the last day's session of the Section on Orthopedic Surgery, during the recent Washington session, Dr. A. H. Freiberg of Cincinnati read a paper on the relationship of physical therapy to orthopedic surgery. It contained excellent points and was discussed by a number of men, all of whom agreed with Dr. Freiberg that heavy responsibility rests on orthopedic surgeons to set physical therapy straight. None of these men made the slightest reference to the Council on Physical Therapy, which is trying to solve the problem in a broad manner and to establish a proper relationship of physical therapy and the general profession. In contrast to the opinions voiced by some orthopedic men that a class of lay "physical therapeutists" be developed, working under their direction, the Council on Physical Therapy advocates that physical therapy be administered, or at least prescribed, by medical men especially trained in
A meta‐analysis on wood dust exposure and risk of asthma
Authors: M. Pérez‐Ríos, A. Ruano‐Ravina, M. Etminan, B. Takkouche
Journal: Allergy (2009)

Work-related asthma is the most common occupational respiratory disorder in the industrialized countries. It has been postulated that wood dust exposure may increase the risk of work-related asthma. The objective of this study was to assess, through a meta-analysis, the risk of developing work-related asthma associated with wood dust exposure. A systematic search of the literature was performed. Inclusion and exclusion criteria were applied and a quality scale used to measure the quality of the included studies was developed. Using standard meta-analysis techniques, studies were pooled using both random and fixed effects models. Nineteen studies were included which consisted of three cohort studies, twelve case-control studies and four mortality studies. The pooled relative risk (RR) of asthma among workers exposed to wood dust was 1.53 (95% CI 1.25-1.87). When the analysis was restricted to studies carried out on Caucasian populations, the pooled RR was 1.59 (95% CI 1.26-2.00) while the pooled RR of studies on Asian populations was 1.15 (95% CI 0.92-1.44). Wood workers present a higher risk of asthma. Future research should include careful evaluation of ethnicity and nativity as risk modifiers.
Debendox and congenital malformations in Northern Ireland.
Authors: R G Shanks, K Griffiths, D W Harron
Journal: BMJ (1981)

An investigation was carried out in Northern Ireland into the alleged association between fetal abnormalities and Debendox, an antiemetic drug used in pregnancy. During the period 1966-78 the total number of births each year and the overall incidence of congenital malformations per 10 000 births fell. The incidences of cleft lip, cleft palate, reduction deformities, and defects of the heart and great vessels fell from 1966 to 1976 but increased in 1977 and 1978. During the same period (1966-78) the number of prescriptions for Debendox issued by general practitioners increased more than fourfold. These observations suggest that there is no relation between congenital malformations and the use of Debendox. This conclusion, however, does not take into account other drug- or environmental-related factors that may have resulted in a reduction in the number of congenital malformations and would hence have masked an increase associated with greater usage of Debendox. In particular, the amount of Debendox sold direct to the public without a prescription and the use of the drug by patients who were not pregnant could not be established. The amount of drug used in these ways is probably small, and it is difficult to see how it might influence the conclusions reached.
Phase II Study of Celecoxib and Docetaxel in Non-small Cell Lung Cancer (NSCLC) Patients with Progression after Platinum-Based Therapy
Authors: Bryan J. Schneider, Gregory P. Kalemkerian, Michael J. Kraut, Antoinette J. Wozniak, Francis P. Worden, Daryn W. Smith, Wei Chen, Shirish M. Gadgeel
Journal: Journal of Thoracic Oncology (2008)
Phosphoinositide Protein Kinase PDPK1 Is a Crucial Cell Signaling Mediator in Multiple Myeloma
Authors: Yoshiaki Chinen, Junya Kuroda, Yuji Shimura, Hisao Nagoshi, Miki Kiyota, Mio Yamamoto-Sugitani, Shinsuke Mizutani, Natsumi Sakamoto, Masaki Ri, Eri Kawata, Tsutomu Kobayashi, Yosuke Matsumoto, Shigeo Horiike, Shinsuke Iida, Masafumi Taniwaki
Journal: Cancer Research (2014)

Multiple myeloma is a cytogenetically/molecularly heterogeneous hematologic malignancy that remains mostly incurable, and the identification of a universal and relevant therapeutic target molecule is essential for the further development of therapeutic strategy. Herein, we identified that 3-phosphoinositide-dependent protein kinase 1 (PDPK1), a serine threonine kinase, is expressed and active in all eleven multiple myeloma-derived cell lines examined regardless of the type of cytogenetic abnormality, the mutation state of RAS and FGFR3 genes, or the activation state of ERK and AKT. Our results revealed that PDPK1 is a pivotal regulator of molecules that are essential for myelomagenesis, such as RSK2, AKT, c-MYC, IRF4, or cyclin Ds, and that PDPK1 inhibition caused the growth inhibition and the induction of apoptosis with the activation of BIM and BAD, and augmented the in vitro cytotoxic effects of antimyeloma agents in myeloma cells. In the clinical setting, PDPK1 was active in myeloma cells of approximately 90% of symptomatic patients at diagnosis, and the smaller population of patients with multiple myeloma exhibiting myeloma cells without active PDPK1 showed a significantly less frequent proportion of the disease stage III by the International Staging System and a significantly more favorable prognosis, including the longer overall survival period and the longer progression-free survival period by bortezomib treatment, than patients with active PDPK1, suggesting that PDPK1 activation accelerates the disease progression and the resistance to treatment in multiple myeloma. Our study demonstrates that PDPK1 is a potent and a universally targetable signaling mediator in multiple myeloma regardless of the types of cytogenetic/molecular profiles.
Absence of the t(14; 18) chromosomal translocation in primary cutaneous B-cell lymphoma: reply from authors
Authors: F.J. Child, R. Russell-Jones, E. Calonje, S.J. Whittaker
Journal: British Journal of Dermatology (2002)

Sir, We thank Dr Hsi and colleagues for their comments. The results obtained from our study suggested that the t(14; 18) translocation does not occur in cases of follicle centre cell lymphoma presenting in the skin unless systemic disease is subsequently identified, underlying the need for exhaustive staging procedures in these cases.1 We agree that the EORTC2 definition of primary cutaneous follicle centre cell lymphoma (PCFCL) includes a more heterogenous group than the REAL/WHO3, 4 definition and the five cases of PCFCL identified in our series were defined according to the criteria of the REAL classification. In our paper we stated that studies involving a larger number of patients were required to confirm our results.1 To date we have seen four further cases of PCFCL (as defined by the REAL classification). Bcl‐2 expression by neoplastic germinal centre cells was identified in only one case and the t(14; 18) translocation was not identified in any of the four cases (using polymerase chain reaction (PCR) methodology and 6% polyacrylamide gel electrophoresis of radiolabelled PCR products).
THE LOSS-OF-FUNCTION IMPACT OF CYP2C19&amp;ast;2 VS. &amp;ast;3 ALLELE IN PATIENTS UNDERGOING PCI TREATED WITH HIGH MAINTENANCE-DOSE CLOPIDOGREL OF 150 MG/DAY: THE RESULTS OF THE ACCEL-DOUBLE-2N3 STUDY
Authors: Young-Hoon Jeong, Udaya Tantry, Yonghwi Park, Seok-Jae Hwang, Kevin Bliden, Choong Hwan Kwak, Jin-Yong Hwang, Paul Gurbel
Journal: Journal of the American College of Cardiology (2012)
TCT-255 Peri-Strut Low Intensity Areas Identified by Optical Coherence Correlated with the Degree of Neointimal Formation After 3 Years Following Stent Implantation in Humans
Authors: Jin-Ho Choi, Juan Granada, Young-Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Sang-Hoon Lee, Jung-Sun Kim, Myeong-Ki Hong, Yang-Soo Jang, Hyeon-Cheol Gwon
Journal: Journal of the American College of Cardiology (2012)
Trip to Paris.
Authors: J. W. Pettit
Journal: JAMA (1900)

Ottawa, Ill., Jan. 10, 1899. <h3>To the Editor:</h3> The committee having in charge the proposed European excursion for the Illinois, Iowa and Missouri state medical societies has just completed its arrangements for the ocean voyage. We shall place our party in charge of Hon. Frank C. Clark, of New York City, who has had a large and successful experience in conducting tourists all over the world. We have assured ourselves that all accommodations will be first-class; and that everything will be done to make the trip an ideal one. The steamship<i>City of Rome</i>has been chartered for our party, and will sail from New York, June 30, 1900. The main trip will occupy thirty-eight days, at a cost of $260, all necessary expenses included. Or if a more extended trip is desired, provision is made for a week in Switzerland and down the Rhine for $70 additional; also a
Electrocardiographic Changes of Hyperkalemia
Authors: J T Kuvin
Journal: New England Journal of Medicine (1998)

Figure 1. A 42-year-old woman with end-stage renal disease from recurrent nephrolithiasis was admitted to the hospital for placement of an arteriovenous fistula for permanent hemodialysis access. While she was undergoing dissection of the brachial artery with local anesthesia, her heart rhythm converted from normal sinus rhythm to complete heart block with a ventricular escape (approximately 25 beats per minute) (Panel A). Two ampules of calcium gluconate (9.2 mEq) were administered intravenously. An electrocardiogram revealed sinus tachycardia with profound prolongation of the QRS interval (left-bundle-branch morphology), first-degree atrioventricular block, and “peaked” T waves (Panel B). The serum potassium concentration was . . .
Recruited Inflammatory Cells Mediate Endotoxin-induced Lung Maturation in Preterm Fetal Lambs
Authors: Suhas G. Kallapur, Timothy J. M. Moss, Machiko Ikegami, Richard L. Jasman, John P. Newnham, Alan H. Jobe
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Rationale: Chorioamnionitis is paradoxically associated with a decreased incidence of respiratory distress syndrome in preterm infants. In preterm lambs, intraamniotic endotoxin and interleukin 1 (IL-1) induce lung inflammation followed by lung maturation.Objective: To test if inflammatory cells are required to mediate induced lung maturation.Methods: Lung inflammation was induced by intraamniotic injection of endotoxin or IL-1. Inflammatory cell recruitment to the lung was inhibited by an anti-CD18 blocking antibody given intramuscularly to the fetus. Preterm lambs were delivered at 124-d gestation (term = 150 d) 2 or 7 d after exposure to endotoxin/IL-1 or endotoxin/IL-1 + anti-CD18 antibody.Measurements: Lung inflammation was measured by bronchoalveolar lavage fluid cell count, inflammatory scoring of lung parenchyma, and expression of proinflammatory cytokines and inducible nitric oxide synthase. Lung maturation was quantitated by surfactant protein mRNA expression, saturated phosphatidylcholine pool size, and pressure–volume curves.Main Results: Inhibition of CD18 significantly reduced endotoxin-induced but not IL-1–induced fetal lung inflammatory cell recruitment and activation as well as expression of proinflammatory cytokines. Compared with control lungs, both endotoxin and IL-1 induced lung maturation. Anti-CD18 antibody administration inhibited only endotoxin-induced but not IL-1–induced increases in surfactant protein mRNA and surfactant saturated phosphatidylcholine. Exposure to anti-CD18 antibody moderated endotoxin-induced increases in lung volumes but had no effect on IL-1–induced increases in lung volumes.Conclusions: (1) Endotoxin- but not IL-1–induced inflammatory cell recruitment in the preterm fetal lamb lung is CD18 dependent; (2) recruited inflammatory cells mediate some aspects of fetal lung maturation.
Early and late initiation of dialysis did not differ for reduction of all-cause mortality in stage 5 chronic kidney disease
Authors: Michael Walsh
Journal: Annals of Internal Medicine (2010)

ACP Journal Club16 November 2010Early and late initiation of dialysis did not differ for reduction of all-cause mortality in stage 5 chronic kidney diseaseMichael Walsh, MD, MScMichael Walsh, MD, MScMcMaster University, Hamilton, Ontario, Canada (M.W.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-10-201011160-02002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationCooper BA, Branley P, Bulfone L, et al. A randomized, controlled trial of early versus late initiation of dialysis. N Engl J Med. 2010;363:609-19. https://pubmed.ncbi.nlm.nih.gov/20581422Clinical Impact RatingsEndocrinology: Nephrology: References1 Hemodialysis Adequacy 2006 Work Group. Clinical practice guidelines for hemodialysis adequacy, update 2006. Am J Kidney Dis. 2006;48:S2-90. [PMID: 16813990] Google Scholar2 Peritoneal Dialysis Adequacy Work Group. Clinical practice guidelines for peritoneal dialysis adequacy. Am J Kidney Dis. 2006;48:S98-129. [PMID: 16813998] Google Scholar3 Kelly J, Stanley M, Harris D. The CARI guidelines. Acceptance into dialysis guidelines. Nephrology (Carlton). 2005;10:S46-60. [PMID: 16221124] Google Scholar Author, Article, and Disclosure InformationAffiliations: McMaster University, Hamilton, Ontario, Canada (M.W.)This article was published at Annals.org on 2 November 2010. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 November 2010Volume 153, Issue 10Page: JC5-2KeywordsChronic kidney diseaseEstimated glomerular filtration rateHospitalizationsIschemic strokeMedical dialysisMortalityMyocardial infarctionObservational studiesRelative riskTransient ischemic attacks ePublished: 16 November 2010 Issue Published: 16 November 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Adaptive response to pneumonectomy in puppies.
Authors: W M Thurlbeck, W Galaugher, J Mathers
Journal: Thorax (1981)

When left pneumonectomy was performed on 9-week-old puppies, the right lung increased in weight, volume, surface area, and number of alveoli so that at age 20 weeks these variables were the same as those of both lungs of control animals and significantly larger than those of the right lung of control animals. The adaptive response of the right lung after pneumonectomy was greater in the lower lobe than in the middle or cardiac lobes. The number of alveoli per ml and the average interalveolar wall distance, hence the surface to volume ratio, was the same in both lungs of control animals and the same in the cardiac, middle, and lower lobes of their right lungs.