tbuckley/cabot-search huggingface dataset:
Upper Airway Obstruction in Obese Patients with Sleep Disturbance and Somnolence
Authors: RONALD E. WALSH
Journal: Annals of Internal Medicine (1972)

In three obese patients with sleep disturbance and somnolence, upper airway obstruction appeared to play the primary pathophysiologic role. The somnolence in these patients was caused by sleep deprivation. Obstruction of the upper airway occurred, airflow ceased, but ineffective thoracoabdominal respiratory efforts persisted. Hypoxia ensued, resulting in electroencephalographic arousal and resumption of effective respirations; thus a cycle of periodic respirations was established. Alveolar hypoventilation, except during the apneic phases of periodic respirations, need not be present in these patients. The clinical and pathophysiologic manifestations can be ameliorated by establishing an airway. In one patient symptoms were abolished by permanent tracheostomy. When the tracheostomy was occluded 1 year later, periodic apnea and sleep disturbances recurred. All obese patients with sleep disturbance or somnolence should be evaluated for upper airway obstruction.
Case of Abortus Infection treated with "Aureomycin"
Authors: J. F. Galpine
Journal: BMJ (1949)

Although the eruption of herpes zoster may appear without discomfort, the pain associated with the condition is some- times considerable; and post-herpetic neuralgia may occur with such severity and persistence that, as Osler (1898) recorded, it has been known to drive a patient to commit suicide.The treatments recommended have been legion, including iron, arsenic, strychnine, gelsemium, valerian, and aconite, as well as the customary analgesics; freezing, liniments, diathermy, and the injection of distilled water beneath the skin have also been used.Dickie (1946) relieved herpetic pain in prisoners of war by use of injections of liver extract, which was the only drug available.I have since had the opportunity of observing the effect of liver extract administered empirically to 20 patients with herpes zoster.In all cases the preparation used was "neo-hepatex," administered intramuscularly.Case Histories Case 1.-June 19, 1946.Male aged 76.Herpes of left fore- head, with severe pain.Dosage: 4 ml.The following day there was no pain and the lesion had not extended.A further 2 ml. was given the next day.There was no post-herpetic pain or recurrence.Case 2.-July 20, 1946.Male aged 47.Herpes of forehead.Dosage: 4 ml.first day, followed by 2 ml. on the two ensuing days.Pain ceased after the first injection.Case 3.-Oct.2, 1946.Female aged 71.Herpes involving the twelfth thoracic segment on the left side, with severe pain.Dosage: Two injections of 4 ml., with three days' interval.Pain completely Wlieved by Oct. 7. Case 4.-Oct.3, 1946.Female aged 63.Herpes of left side of head and neck, with severe pain.Dosage: 4 ml.on Oct. 3 and Oct. 5. Completely free from paifn after Oct. 5. Case 5.-Oct.4, 1946.Male aged 16.Herpes of right buttock and thigh, with moderate pain.Dosage: 4 ml.Pain and vesicles disappeared in 24 hours.Case 6.-Oct.14, 1946.Male aged 77.Complained of postherpetic neuralgia for 10 months.Dosage: 4 ml., with.relief of pain.A further 4 ml.was injected on Oct. 16.Case 7.-Oct.28, 1946.Male aged 68.Post-herpetic neuralgia for 15 months.Three injections of 4 ml.produced no diminution of pain.Case 8.-Nov.28, 1946.Male aged 38.Herpes genitalis for 6 weeks.Dosage: 4 ml.on two successive days.By Dec. 3 the herpes had disappeared.Case 9.-Jan.13, 1947.Male aged 23.Herpes of left chest, with moderate pain.Dosage: 4 ml.on three successive days.Pain-free on Jan. 16.Case IO.-Jan.14, 1947.Female aged 75.Three days' history of herpes of right thigh, groin, and lower abdomen, with severe pain.Dosage: 4 ml.on two successive days.-Complete relief of pain.Case 11.-May 5, 1947.Female aged 56.Herpes of right upper thorax, right shoulder, and neck, associated with severe pain.Dosage: 4 ml.on May S and May 6; 2 ml. on May 10.The pain became considerably less by May 8, and the patient was pain-free on May 12.Case 12.-July 1, 1947.Female aged 59.Two weeks' his- tory of herpes of forehead, with moderate pain.Dosage: 4 ml.on July 1 and July 2, with diminution of pain.Case1-13-July 14 1947.Male aged 66. Herpes of left face for a week.Dosage: 4 ml.on July 15, 17, and 19.Pain
Phage Typing of Antibiotic-Resistant Staphylococci
Authors: Joseph F. Metzger, Matthew H. Fusillo, Richard N. Roerig, Kenneth F. Ernst
Journal: New England Journal of Medicine (1954)

IN previous reports1 , 2 the high incidence of similar phage patterns of the antibiotic-resistant staphylococci that were isolated from lesions from various clinical sources within a large medical center was noted. Over 48 per cent of the organisms that could be typed by present methods occurred in one of seven phage patterns (47/53/54/75, VA4/53, 7, 7/53, 53, 47/53/75 and 47/53/73), and over three fourths of those isolated from refractory staphylococcal lesions occurred in one of these phage patterns. Current studies indicate that approximately 70 per cent of the staff members of this installation carry antibiotic-resistant staphylococci with multiple resistance to penicillin, . . .
Peptic ulcer and gastric secretion in patients with liver disease
Authors: S. Tabaqchali, A. M. Dawson
Journal: Gut (1964)

SYNOPSISThe overall incidence of peptic ulcer in 290 patients with portal cirrhosis was 113 %.The incidence was the same in male and female patients whether or not the patient had an alcoholic history and whether or not they had had a portacaval anastomosis.No abnormality of gastric secretion was observed in patients with hepatic cirrhosis except after a portacaval anastomosis when the basal gastric acid secretion increases, but there is no concomitant increase in response to maximum histamine stimulation.In addition the gastric contents both at night when fasting and during the day on a standardized diet were more acid in patients who had undergone a portacaval anastomosis than in patients with uncomplicated hepatic cirrhosis.
MULTICENTER REGISTRY DATA IN JAPAN FOR RETROGRADE PCI OF CHRONIC TOTAL OCCLUSION DURING THE PAST THREE YEARS: HAVE NEW DEVICES AND TECHNIQUES CHANGED THE STRATEGIES OF RETROGRADE APPROACH?
Authors: Ryohei Yoshikawa, Etsuo Tsuchikane, Toshiya Muramatsu, Shigeru Nakamura, Atsunori Okamura, Yasumi Igarashi, Tetsuo Matsubara, Tsutomu Fujita, Makoto Muto, Masahisa Yamane
Journal: Journal of the American College of Cardiology (2013)
Nordic MCL3 study: 90Y-ibritumomab-tiuxetan added to BEAM/C in non-CR patients before transplant in mantle cell lymphoma
Authors: Arne Kolstad, Anna Laurell, Mats Jerkeman, Kirsten Grønbæk, Erkki Elonen, Riikka Räty, Lone Bredo Pedersen, Annika Loft, Trond Velde Bogsrud, Eva Kimby, Per Boye Hansen, Unn-Merete Fagerli, Herman Nilsson-Ehle, Grete Fossum Lauritzsen, Anne Kristine Lehmann, Christer Sundstrom, Marja-Liisa Karjalainen-Lindsberg, Elisabeth Ralfkiaer, Mats Ehinger, Jan Delabie, Hans Bentzen, Jukka Schildt, Kamelia Kostova-Aherdan, Henrik Frederiksen, Peter de Nully Brown, Christian H. Geisler
Journal: Blood (2014)
Phospho-Akt Expression Is Associated with a Favorable Outcome in Non–Small Cell Lung Cancer
Authors: Amit Shah, William A. Swain, Donna Richardson, John Edwards, Duncan J. Stewart, Catherine M. Richardson, Daniel E.B. Swinson, Dipika Patel, J. Louise Jones, Kenneth J. O'Byrne
Journal: Clinical Cancer Research (2005)

Abstract Akt, a Serine/Threonine protein kinase, mediates growth factor–associated cell survival. Constitutive activation of Akt (phosphorylated Akt, P-Akt) has been observed in several human cancers, including lung cancer and may be associated with poor prognosis and chemotherapy and radiotherapy resistance. The clinical relevance of P-Akt in non–small cell lung cancer (NSCLC) is not well described. In the present study, we examined 82 surgically resected snap-frozen and paraffin-embedded stage I to IIIA NSCLC samples for P-Akt and Akt by Western blotting and for P-Akt by immunohistochemistry. P-Akt protein levels above the median, measured using reproducible semiquantitative band densitometry, correlated with a favorable outcome (P = 0.007). Multivariate analysis identified P-Akt as a significant independent favorable prognostic factor (P = 0.004). Although associated with a favorable prognosis, high P-Akt levels correlated with high tumor grade (P = 0.02). Adenocarcinomas were associated with low P-Akt levels (P = 0.039). Akt was not associated with either outcome or clinicopathologic variables. Cytoplasmic (CP-Akt) and nuclear (NP-Akt) P-Akt tumor cell staining was detected in 96% and 42% of cases, respectively. Both CP-Akt and NP-Akt correlated with well-differentiated tumors (P = 0.008 and 0.017, respectively). NP-Akt also correlated with nodal metastases (P = 0.022) and squamous histology (P = 0.037). These results suggest P-Akt expression is a favorable prognostic factor in NSCLC. Immunolocalization of P-Akt, however, may be relevant as NP-Akt was associated with nodal metastases, a known poor prognostic feature in this disease. P-Akt may be a potential novel therapeutic target for the management of NSCLC.
Infection with Coxsackie Virus Group B, Type 3, with Vesicular Eruption — Report of Two Cases
Authors: A. Martin Lerner, Jerome O. Klein, Maxwell Finland, Priscilla Bills
Journal: New England Journal of Medicine (1960)

DESPITE the frequent occurrence of infections with Coxsackie virus Group B we could find only 1 report of a case of such infection accompanied by an exanthem.1 This was in a nine-month-old boy with fever and a "rubella-like exanthem" from whom Coxsackie virus Group B, Type 1, was recovered from the stool, and a rise in neutralizing antibody to that virus was demonstrated in the serum. Vesicular eruptions have been associated with infections due to Coxsackie virus Group A, Type 16,2 ECHO virus Type 43 and Coxsackie virus Group A, Type 9.4 Two cases of vesicular eruption associated with Coxsackie . . .
Prolonged Unconsciousness Following Electroconvulsive Therapy
Authors: BARBARA MOSS-HERJANIC
Journal: American Journal of Psychiatry (1967)

A case is presented of a 49-year-old man with prolonged coma following ECT and a history of jacksonian seizures starting with a head injury at age 12. The patient's symptoms following ECT were controlled by the use of diphenylhydantoin.
Successful Management of Pregnancy and Delivery in a Patient with an Iliofemoral Arterial Prosthesis
Authors: Walter S. Clough
Journal: New England Journal of Medicine (1962)

OBSTETRIC textbooks and reports from maternity centers fail to mention what must be a very rare and serious complication for a woman in the childbearing years, the rupture of an arterial aneurysm with its successful repair by prosthesis, as an indication for primary cesarean section. This report is intended to document this experience, with a discussion of the problems concerned in the management of such a case during pregnancy.Case ReportA 33-year-old gravida 10, para 6, made her 1st prenatal visit on November 2, 1960. Physical examination revealed that she was approximately 3 months pregnant, the estimated date of . . .
Surgeon facing fitness to practise allegations can leave medical register
Authors: C. Dyer
Journal: BMJ (2014)

A surgeon accused of botching operations over an 18 year period at four hospitals in Kent has been allowed to remove himself from the medical register after a hearing behind closed doors.

The Medical Practitioners Tribunal Service (MPTS) accepted expert evidence that David Jackson, who faced a 45 day hearing with 75 counts relating to 16 patients between 1989 and 2007, was so ill that he was unable to instruct his lawyers or participate in a hearing, and would never be fit to practise medicine again.

The tribunal service panel said that his illness, details of which were not revealed, could have …
Transmission of Creutzfeldt-Jakob disease in corneal grafts
Authors: B. Allan, S. Tuft
Journal: BMJ (1997)

The public and political profile of transmissible spongiform encephalopathies has changed dramatically with the identification of a new variant of Creutzfeldt-Jakob disease1 and continued uncertainty about the size of the threat this may represent. Against this background, the Scottish Office confirmed last month that ocular tissue from a donor who was later found to have classic (sporadic) Creutzfeldt-Jakob disease had been transplanted into three patients. Press coverage of this announcement is certain to stimulate concern among potential recipients of corneal grafts and a reanalysis of measures to prevent iatrogenic disease transmission.

latrogenic transmission of Creutzfeldt-Jakob disease was first reported in 1974 in a 55 year old woman who developed symptoms 18 months after corneal transplantation from a donor who was found to have died of the disease.2 Two similar cases have since been identified,3 and the potential for transmission of spongiform encephalopathies, including Creutzfeldt-Jakob disease, via …
Morphological and quantitative analyses of normal epidermal Langerhans cells using confocal scanning laser microscopy
Authors: R.C. YU, D.C. ABRAMS, M. ALAIBAC, A.C. CHU
Journal: British Journal of Dermatology (1994)

Confocal scanning laser microscopy (CSLM), when used in conjunction with computerized image processing systems, porovides a powerful tool for morphological and quantitative analyses of biological tissues. In this study, normal human epidermal sheets were stained by an indirect immunofluorescence method using anti-CD1a monoclonal antibody. Positively stained epidermal Langerhans cells (LCs) were visualized using the Bio-Rad MRC-600 Confocal Imaging System. Images obtained from the confocal microscope were volumetrically rendered and quantitatively analysed using ANALYZE® (Version 4.0) running on a Sun SPARC 2 Workstation. Normal epidermal LCs were shown to be large disc-like structures with five to nine long dendritic processes per cell, orientated with their flat surfaces parallel to the skin surface. LCs form a monolayer network of cells distributed evenly throughout the suprabasal layers of the epidermis, with no direct physical contact between dendritic processes. Mean LC density was estimated to be 582 per mm2 (95% confidence intervals, CI=233−940), and mean cell volume was 612μm3 (95% CI=257−1020). LCs in sun-exposed sites were significantly lower in mean cell density, but larger in mean cell volume, than in covered sites. Mean surface area projected by LCs was estimated to be 26.8% (95% CI=18.9−34.2), and this value did not show significant regional or individual variation. Our data support the notion that epidermal LCs are organized in such a way as to maximize their surface area for efficient trapping of antigens, and a reduction in LC density per unit area in sun-exposed sites is compensated for by an increase in the mean cell volume.
Reply to Letter Regarding Article, “Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction”
Authors: Gad A. Silberman, Tai-Hwang M. Fan, Zhe Jiao, Beth M. Boulden, Julian Widder, Scott Fredd, Sergey Dikalov, David G. Harrison, Joshua D. Lovelock, Hong D. Xiao, Beata M. Wolska, Hong Liu, Samuel C. Dudley, Kenneth E. Bernstein
Journal: Circulation (2010)
Neonatal Thrombocytopenia and Thiazide Drugs
Authors: G. X. Trimble
Journal: BMJ (1964)

accurate list of these questions and I cannot agree with Professor Kekwick that 90% have been clinical.Indeed, I would put the true figure as at most 30%.But I would not be in the least surprised to know that the pro- fessor has some peculiarly personal definition of the word " clinical."Would he regard the following sample question, which was one recently asked, as clinical or as a sadistic joke at the candidate's expense, and not to be taken seriously ?Which of the following is correct?Kala-azar is black man's disease Kwashiorkor is red dog disease
Sex‐specific acute heart failure phenotypes and outcomes from PROTECT
Authors: Sven Meyer, Peter van der Meer, Barry M. Massie, Christopher M. O'Connor, Marco Metra, Piotr Ponikowski, John R. Teerlink, Gad Cotter, Beth A. Davison, John G.F. Cleland, Michael M. Givertz, Daniel M. Bloomfield, Mona Fiuzat, Howard C. Dittrich, Hans L. Hillege, Adriaan A. Voors
Journal: European Journal of Heart Failure (2013)
Lactic dehydrogenase isozymes, 31P magnetic resonance spectroscopy, and in vitro antimitochondrial tumor toxicity with gossypol and rhodamine-123.
Authors: C Benz, C Hollander, M Keniry, T L James, M Mitchell
Journal: Journal of Clinical Investigation (1987)

Three compounds that share specific antimitochondrial properties are gossypol, rhodamine-123, and lonidamine. We compare the antiproliferative activities of these drugs against six human cell lines derived from breast (T47-D), pancreas (MiaPaCa, RWP-2), prostate (DU-145), colon (HCT-8), and cervix (HeLa) carcinomas. Tumor cells enriched in cathodal LDH isozymes (LDH4 and LDH5) are significantly more sensitive to gossypol and rhodamine-123. When compared for ability to inhibit growth of human marrow in soft agar, 10 microM gossypol shows little effect on colony formation whereas 10 microM rhodamine-123 completely prevents stem cell growth, suggesting that gossypol may have the most favorable therapeutic index. Within 24 h of drug administration, there is a relative increase in intracellular inorganic phosphate pools and a marked decline in soluble high-energy phosphates in sensitive tumor cells, as measured by 31P magnetic resonance spectroscopy. These studies suggest that specific antimitochondrial agents might be selectively administered on the basis of tumor LDH isozyme content and noninvasively monitored for antiproliferative activity by 31P spectroscopy.
Historical perspective and clinical implications of the Pelger‐Huet cell
Authors: John M. Cunningham, Mrinal M. Patnaik, Dale E. Hammerschmidt, Gregory M. Vercellotti
Journal: American Journal of Hematology (2008)

The unique historical aspects of Pelger and Huet's discovery of the Pelger-Huet cell highlight the diagnostic challenge that this morphologic finding presents to the physician. Making the diagnosis of the benign autosomal dominant anomaly is complicated by the morphologically similar pseudo-Pelger-Huet cell, which can signify underlying myeloid dsyplasia. This article relates the history of the Pelger-Huet anomaly as well as describes the clinical significance and diagnostic workup for the finding of a Pelger-Huet cell on peripheral smear.
Administration of physiologic levels of triiodothyronine increases leptin expression in calorie-restricted obese rats, but does not influence weight loss
Authors: Renata A.M. Luvizotto, Sandro J. Conde, Maria T. Síbio, André F. Nascimento, Ana P. Lima-Leopoldo, André S. Leopoldo, Carlos R. Padovani, Antônio C. Cicogna, Célia Regina Nogueira
Journal: Metabolism (2009)
Premature Adrenarche—Normal Variant or Forerunner of Adult Disease?*
Authors: Lourdes Ibáñez, Joan DiMartino-Nardi, Neus Potau, Paul Saenger
Journal: Endocrine Reviews (2000)

Abstract Adrenarche is the puberty of the adrenal gland. The descriptive term pubarche indicates the appearance of pubic hair, which may be accompanied by axillary hair. This process is considered premature if it occurs before age 8 yr in girls and 9 yr in boys. The chief hormonal product of adrenarche is dehydroepiandrosterone (DHEA) and its sulfated product DHEA-S. The well documented evolution of adrenarche in primates and man is incompatible with either a neutral or harmful role for DHEA and implies most likely a positive role for some aspect of young adult pubertal maturation and developmental maturation. Premature adrenarche has no adverse effects on the onset and progression of gonadarche in final height. Both extra- and intraadrenal factors regulate adrenal androgen secretion. Recent studies have shown that premature adrenarche in childhood may have consequences such as functional ovarian hyperandrogenism, polycystic ovarian syndrome, and insulin resistance in later life, sometimes already recognizable in childhood or adolescence. Premature adrenarche may thus be a forerunner of syndrome X in some children. The association of these endocrine-metabolic abnormalities with reduced fetal growth and their genetic basis remain to be elucidated.
Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): a review of four consecutive childhood AML trials conducted between 1981 and 2000
Authors: Y Ravindranath, M Chang, C P Steuber, D Becton, G Dahl, C Civin, B Camitta, A Carroll, S C Raimondi, H J Weinstein
Journal: Leukemia (2005)
1031. Improved Intranuclear Delivery of PNA- Peptide Conjugates Designed for Chromosomal Gene Targeting
Authors: Faye A. Rogers, Peter M. Glazer
Journal: Molecular Therapy (2006)

Peptide nucleic acids (PNAs) are DNA binding molecules, which offer the potential to selectively modulate gene expression. These DNA analogues in which the purine and pyrimidine bases are attached to a polyamine backbone, maintain a spacing similar to DNA, but result in an achiral, neutrally charged molecule. PNAs can bind to DNA via Watson-Crick complementarity, with binding affinities significantly higher than those of the corresponding DNA oligomers. However, the biological activity of these potential antigene compounds has been limited by inefficient cellular uptake. Currently, the techniques used to introduce these molecules into cells, microinjection, co-mixture with cationic lipids, and electroporation, are limited by their cytotoxic effects. Here, we investigate the effect of cell-penetrating peptides on the biological activity of PNAs as measured in an assay for gene-targeted mutagenesis. Using the transport peptide derived from the third helix of the homeodomain of antennapedia (Antp), we tested PNA-peptide conjugates compared to unmodified PNAs. Confocal microscopy studies indicated increased cellular uptake of PNA when linked to Antp, consistent with the gene targeting data. Furthermore, i.p. injection of labeled PNA-Antp conjugate indicate in vivo nuclear uptake in mouse tissue. These results suggest that peptide conjugation may enhance intranuclear delivery of reagents designed to bind to chromosomal DNA, thus improving antigene potential.