tbuckley/cabot-search huggingface dataset:
Renal Failure and Angiodysplasia of the Colon
Authors: C. THOMAS FLYNN
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 July 1985Renal Failure and Angiodysplasia of the ColonC. THOMAS FLYNN, M.D., PREM K.G. CHANDRAN, M.D.C. THOMAS FLYNN, M.D.Search for more papers by this author, PREM K.G. CHANDRAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-1-154_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the recent paper (1) on upper gastrointestinal bleeding in patients with chronic renal failure. We write to report the cases of two patients on maintenance hemodialysis who had colonic angiodysplasia causing persistent lower intestinal hemorrhage.A 75-year-old white woman was on outpatient hemodialysis for end-stage renal disease due to hypertensive nephrosclerosis. She had worsening anemia and hematochezia 4 months after commencement of renal replacement therapy. Intensive investigation using panendoscopy, visceral angiography, and technetium-labeled erythrocyte bleeding study showed that the bleeding was due to ascending colonic angiodysplasia. Right hemicolectomy was done but failed to...Reference1. ZUCKERMAN G, CORNETT G, CLOUSE R, and HARTEL H. Upper gastrointestinal bleeding in patients with chronic renal failure. Ann Intern Med. 1985;102:588-92. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: C. THOMAS FLYNN, M.D.; PREM K.G. CHANDRAN, M.D.Affiliations: Renal Dialysis Unit Iowa Lutheran Hospital Des Moines, IA 50316 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIndicación quirúrgica por angiodisplasia del colon: análisis de una serieDialysis in the elderlyDiagnostic and therapeutic impact of push enteroscopy: analysis of factors associated with positive findingsGastrointestinal Complications of Renal FailureDialysis in the Elderly 1 July 1985Volume 103, Issue 1Page: 154-154KeywordsAnemiaAngiographyColectomyColonHemorrhageOutpatientsRenal failure ePublished: 1 December 2008 Issue Published: 1 July 1985 PDF downloadLoading ...
Thoughts from the long-term memory chair
Authors: Jonathan K. Foster
Journal: Behavioral and Brain Sciences (2003)

With reference to Ruchkins et al.'s framework, this commentary briefly considers the history of working memory, and whether, heuristically, this is a useful concept. A neuropsychologically motivated critique is offered, specifically with regard to the recent trend for working-memory researchers to conceptualise this capacity more as a process than as a set of distinct task-specific stores.
Effects of Infusion of Hyperoncotic Dextran in Children with the Nephrotic Syndrome1
Authors: John James, Gustavo Gordillo, Jack Metcoff
Journal: Journal of Clinical Investigation (1954)

Dextran is a bacterial polysaccharide which is being increasingly used as a plasma substitute (1-4). Dextran molecules frequently have a molecular weight of several million, and consist of long branched chains of glucose units. For clinical use these large molecules are broken down artificially to an average molecular weight of 70,000. In the body, the larger molecular aggregates are further broken down and excreted as smaller fractions having (approximate) molecular weights less than 20,000, or are slowly metabolized. Dextran has been reported to induce diuresis regularly in patients with the nephrotic syndrome (5, 6). In addition to determining the clinical value of dextran, the intravenous infusion of hyperoncotic (12 per cent) dextran in water was used as an approach to the study of the following questions:
Prediction of Coronary Heart Disease in a Population With High Prevalence of Diabetes and Albuminuria
Authors: Elisa T. Lee, Barbara V. Howard, Wenyu Wang, Thomas K. Welty, James M. Galloway, Lyle G. Best, Richard R. Fabsitz, Ying Zhang, Jeunliang Yeh, Richard B. Devereux
Journal: Circulation (2006)

The present article presents equations for the prediction of coronary heart disease (CHD) in a population with high rates of diabetes and albuminuria, derived from data collected in the Strong Heart Study, a longitudinal study of cardiovascular disease in 13 American Indian tribes and communities in Arizona, North and South Dakota, and Oklahoma.Participants of the Strong Heart Study were examined initially in 1989-1991 and were monitored with additional examinations and mortality and morbidity surveillance. CHD outcome data through December 2001 showed that age, gender, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein cholesterol, smoking, diabetes, hypertension, and albuminuria were significant CHD risk factors. Hazard ratios for ages 65 to 75 years, hypertension, LDL cholesterol > or = 160 mg/dL, diabetes, and macroalbuminuria were 2.58, 2.01, 2.44, 1.66, and 2.11 in men and 2.03, 1.69, 2.17, 2.26, and 2.69 in women, compared with ages 45 to 54 years, normal blood pressure, LDL cholesterol <100 mg/dL, no diabetes, and no albuminuria. Prediction equations for CHD and a risk calculator were derived by gender with the use of Cox proportional hazards model and the significant risk factors. The equations provided good discrimination ability, as indicated by a c statistic of 0.70 for men and 0.73 for women. Results from bootstrapping methods indicated good internal validation and calibration.A "risk calculator" has been developed and placed on the Strong Heart Study Web site, which provides predicted risk of CHD in 10 years with input of these risk factors. This may be valuable for diverse populations with high rates of diabetes and albuminuria.
Increased Circulating IgE in a New Parasitic Disease — Human Intestinal Capillariasis
Authors: Eugene B. Rosenberg, George E. Whalen, Hans Bennich, S. Gunnar O. Johansson
Journal: New England Journal of Medicine (1970)

STUDIES of an epidemic of intestinal capillariasis that occurred in the Philippines beginning in 1967 showed that a newly discovered species of roundworm, Capillaria philippinensis, was causing life-threatening diarrhea, malabsorption, and enteric protein loss in man.1 The recent interest in IgE levels in parasitic diseases and the association of malabsorption syndromes with acquired deficits of immunoglobulin synthesis prompted this study of circulating immunoglobulin levels in patients with intestinal capillariasis and in Filipino controls. IgE, IgD, IgA, IgG and IgM levels were quantitated2 3 4 before and after patients were treated with thiabendazole,5 an antihelminthic that eliminates C. philippinensis parasites.ResultsImmunoglobulin . . .
Multidrug resistance responsible for half of deaths from healthcare associated infections in Europe
Authors: Rory Watson
Journal: BMJ (2008)

Multidrug resistant bacteria are responsible for about half of the 37 000 deaths a year in the 27 member states of the European Union that are caused by infections associated with health care, show the preliminary results of research from the European Centre for Disease Prevention and Control, in Stockholm.

The official findings, which will be presented later this summer, coincide with growing political and medical pressure for a reduction in the use of antibiotics in a bid to curb increases in drug resistant bacteria.

Dominique Monnet, the centre’s …
Estrogen and Postmenopausal Osteoporosis
Authors: Shawn McGivney
Journal: Annals of Internal Medicine (1993)

Letters15 January 1993Estrogen and Postmenopausal OsteoporosisShawn McGivney, MDShawn McGivney, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-2-199301150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Although I agree with Lufkin and colleagues' [1] conclusion that estrogens appear effective in the treatment of osteoporosis, several issues should be clarified. First, the selection criteria included women with existing compression fractures, a major confounding factor because they may lead to artifactual increases in bone density measurements. This factor is unlikely to pose a major problem in this study because of 1) the randomized design and 2) the demonstration that both mechanical (additional compression fractures) and metabolic measures (osteocalcin and hydroxyproline levels) also showed improvement. Nevertheless, caution is needed because bone density readings are potentially misleading, ...References1. Lufkin EG, Wahner HW, O'Fallon WM, Hodgson SF, Kotowicz MA, Lane AW, et al. Treatment of postmenopausal osteoporosis with transdermal estrogen. Ann Intern Med. 1992; 117:1-9. Google Scholar2. Notelovitz, et al. Estrogen therapy and variable resistance weight training increases bone mineral in surgically menopausal women. J Bone Miner Res. 1991; 6:583-90. Google Scholar3. Myburgh, et al. Low bone density is an etiologic factor for stress fractures in athletes. Ann Intern Med. 1990; 113:754-9. Google Scholar4. Drinkwater, et al. Bone mineral content of amenorrheic and eumenorrheic athletes. N Engl J Med. 1984; 311:277-81. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1993Volume 118, Issue 2Page: 155-156KeywordsBone densityCardiovascular therapyEstrogensExerciseHysterectomyOsteocalcinOsteoporosisProgesteroneResearch design Issue Published: 15 January 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
What is the efficacy of the RTS,S malaria vaccine?
Authors: C. J. A. Duncan, A. V. S. Hill
Journal: BMJ (2011)

Whitty’s editorial puts the recent phase III RTS,S malaria vaccine trial results in the wider context of malaria control.1 2 Although vaccines are an important component of this effort, they are not necessarily the complete solution. RTS,S is a big step in the right direction, but further advances are needed to produce a highly effective malaria vaccine.1

The …
Abstract 3567: Estrogen signaling promotes effective progesterone receptor engagement with DNA in breast cancer cells.
Authors: Erin E. Swinstead, Andrew P. Trotta, Eric Smith, Phulwinder K. Grover, Eleanor F. Need, Grant Buchanan
Journal: Cancer Research (2013)

Abstract Estrogens and progesterone (PROG) are key mediators of breast cancer aetiology and progression. The predominant actions of these hormones in the breast are mediated via their respective cognate steroid receptors, estrogen receptor alpha (ERα) and progesterone receptor (PGR). As ERα upregulates PGR expression, both are currently measured in clinical breast cancer samples to determine the utility of anti-estrogen therapy. Although the molecular actions of estrogens have been extensively studied, the role of PROG and PGR need further elucidation, particularly in the context of activated ERα signaling. Here, we treated ZR75-1 cells with 17β-estradiol (E2) alone or in combination with PROG and assessed global transcriptional responses by microarray expression profiling and receptor binding profiles by chromatin immunoprecipitation-sequencing (ChIP-seq). PROG treatment alone significantly altered the regulation of only seven genes, whereas long term E2 treatment increased the PROG transcriptional response altering 785 genes (p value ≤ 0.05), and regulated pathways involved in ErbB signalling and cell proliferation. Consistent with these findings, ChIP-seq identified 10 times more PGR binding sites following long term E2 treatment (4566 at equivalent peak threshold) compared with PROG treatment alone. Candidate PGR ChIP validated these findings at 100% (12/12) sites tested. The long term E2-treated PGR cistrome was highly conserved amongst species, and enriched for progesterone receptor response elements (PREs) and FOXA1 binding sites. E2 enhancement of PGR binding could be abrogated by long term (72h) but not short term (4h) tamoxifen co-treatment. In T-47D cells, long term E2 treatment was not required for efficient interaction of PGR with DNA and FOXA1 silencing resulted in decreased PGR DNA occupancy at several sites. These data suggests that the combination of E2 and PROG regulated a distinct transcriptional response in breast cancer cells, perhaps due to the dependence of PGR on E2 signaling for maintenance of cellular PGR levels, and via the receptors sharing mutual collaborators and coregulators, such as FOXA1. ERα and PGR collectively shape a mitogenic response in breast cancer cells that is dependent on the combined presence of E2 and PROG. Citation Format: Erin E. Swinstead, Andrew P. Trotta, Eric Smith, Phulwinder K. Grover, Eleanor F. Need, Grant Buchanan. Estrogen signaling promotes effective progesterone receptor engagement with DNA in breast cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3567. doi:10.1158/1538-7445.AM2013-3567
URTICARIA, A THERAPEUTIC NOTE.
Authors: BERNARD WOLFF
Journal: JAMA (1897)

The list of remedies suggested for the relief of urticaria is already so voluminous that I would have some hesitation in further adding to it, were I not thoroughly convinced of the value of phosphate of soda in the treatment of this common complaint. I have used this drug for the past year in quite a large number of cases, and with such uniform success that I have come to regard it as absolute master of the disease, and have ceased to have any of my former misgivings of my ability to promptly relieve the patient. In acute cases in adults my plan is to give dram doses of a supersaturated solution of phosphate of soda,<i>i. e.</i>, sixty to eighty grains to the dram, the salt being dissolved in its own water of crystallization. This is to be repeated every three hours, and in addition the following antipruritic lotion
Further evidence for the involvement of nitric oxide in trans-ACPD-induced suppression of AMPA responses in cultured chick Purkinje neurons
Authors: Junko Mori-Okamoto, Koichi Okamoto
Journal: Behavioral and Brain Sciences (1996)

In addition to SNP and SIN-1, SNAP suppresses AMPA responses. This suppression is antagonized by carboxy-PTIO in cultured chick cerebellar Purkinje neurons. Intracellular application of cGMP shows a long-lasting suppression of AMPA responses mimicking the cerebellar LTD. These recent results demonstrate that NO can induce LTD-like suppression of AMPA responses and intracellular cGMP and cGMP-dependent protein kinase participate in this suppression. [CRÉPEL et al.; LINDEN; VINCENT]
Sonographically Guided Fine-Needle Aspiration of Liver Lesions
Authors: Ruth Rosenblatt
Journal: JAMA (1982)

FINE-needle percutaneous aspiration biopsy of the liver and other intraabdominal organs has been shown to be a safe and accurate method for the cytological diagnosis of cancer.<sup>1-4</sup>When combined with an imaging modality such as ultrasound, computed tomography, or fluoroscopy, the diagnostic yield has been reported to be from 85% to 100%.<sup>1-4</sup>The liver is easily depicted sonographically. With present-day ultrasound equipment, lesions as small as 2 cm can be imaged. Since 1978 the radiologists in this group of authors have used ultrasound as a guide in aspirating focal masses in the liver. This method has provided rapid and accurate diagnoses in 45 of 59 patients, thus eliminating other more costly and time-consuming studies. <h3>Materials and Methods</h3> The chief indication for performing a guided percutaneous thin-needle aspiration was the demonstration of a focal solid or semisolid liver mass on an initial diagnostic scan (Figure). Before the aspiration biopsy
Automatic processes, emotions, and the causal field
Authors: Robin M. Hogarth
Journal: Behavioral and Brain Sciences (2014)

Newell & Shanks (N&S) provide a welcome examination of many claims about unconscious influences on decision making. I emphasize two issues that they do not consider fully: the roles of automatic processes and emotions. I further raise an important conceptual problem in assigning causes to potential unconscious influences. Which "causal field" is relevant: that of the investigator or the experimental participants?
Continuous Murmur Due to the Combination of Rheumatic Mitral Stenosis and a Rare Type of Anomalous Pulmonary Venous Drainage
Authors: B. L. HALPERN, G. C. MURRAY, C. R. CONTI, J. O. HUMPHRIES, V. L. GOTT
Journal: Circulation (1970)

A patient is described in whom a continuous murmur was caused by the combination of rheumatic mitral stenosis and a rare form of partial anomalous pulmonary venous drainage. In this case, the left superior pulmonary vein drained into the left atrium and also into a large anomalous vein which then drained to the right atrium via the innominate vein and superior vena cava. At surgery, mitral commissurotomy and then ligation of the anomalous vein were performed with a good result; the continuous murmur was no longer audible after operation. The embryology, physiology, auscultatory findings and surgical consideration are discussed.
Inflammatory and Anti-glioma Effects of an Adenovirus Expressing Human Soluble Fms-like Tyrosine Kinase 3 Ligand (hsFlt3L): Treatment with hsFlt3L Inhibits Intracranial Glioma Progression
Authors: Sumia Ali, James F. Curtin, Jeffrey M. Zirger, Weidong Xiong, Gwendalyn D. King, Carlos Barcia, Chunyan Liu, Mariana Puntel, Shyam Goverdhana, Pedro R. Lowenstein, Maria G. Castro
Journal: Molecular Therapy (2004)

Glioblastoma multiforme is an intracranial tumor that has very poor prognosis. Patients usually succumb to their disease 6 to 12 months after they are diagnosed despite very aggressive treatment modalities. We tested the efficacy of a potent differentiation and proliferation factor for the professional antigen-presenting dendritic cells (DCs), i.e., Flt3L, for its potential role as a novel therapy for gliomas. We investigated the ability of recombinant adenoviral vectors encoding human soluble Flt3L (hsFlt3L) to improve the survival of Lewis rats bearing intracranial syngeneic CNS-1 gliomas. We show that RAdhsFlt3L can improve survival in a dose-dependent manner. Seventy percent of rats survive when treated with 8 × 107 pfu RAdhsFlt3L (P < 0.0005). In addition we demonstrate in both naïve Lewis rats and C57BL/6 mice the presence of increased numbers of cells bearing DC markers (OX62 and MHCII, in rats, or CD11C, 33D1, MHCII, and F4/80, but not DEC205, in mice) in sites of brain delivery of RAdhsFlt3L. These results show that expression of hsFlt3L in the brain leads to the presence of cells displaying DC markers. We demonstrate that treatment with hsFlt3L leads to inhibition of tumor growth and significantly increased life span of animals implanted with syngeneic CNS-1 glioma cells. Animals that had survived for long periods, i.e., 6 months, had eliminated the implanted tumors after neuropathological analysis; on the other hand, some of the 3-month survivors still appeared to harbor brain tumors. Our results have profound implications for immune-mediated brain tumor therapy and also suggest the ability to recruit DC-like cells within the brain parenchyma in response to the local expression of Flt3L from adenoviral vectors.
Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development
Authors: Vikram R. Paralkar, Tejaswini Mishra, Jing Luan, Yu Yao, Andrew V. Kossenkov, Stacie M. Anderson, Margaret Dunagin, Maxim Pimkin, Meghneel Gore, Diana Sun, Neeraja Konuthula, Arjun Raj, Xiuli An, Narla Mohandas, David M. Bodine, Ross C. Hardison, Mitchell J. Weiss
Journal: Blood (2014)
Physician Counseling About Exercise
Authors: Christina C. Wee
Journal: JAMA (1999)

The increase in sedentary lifestyle may contribute to the rise in obesity nationally. Although guidelines suggest that physicians counsel all patients about exercise, physicians counsel only a minority of their patients. Whether patient factors influence physician counseling is not well established.To examine and to identify factors associated with exercise counseling by US physicians.National population-based supplemental (Year 2000) survey to the 1995 National Health Interview Survey.Of the 17317 respondents to the Year 2000 supplemental survey, 9711 adults had seen a physician in the previous year, and 9299 responded when asked about physician counseling on exercise.Physician counseling to begin or to continue to exercise.Of 9299 respondents, 34% reported being counseled about exercise at their last visit. After adjustment for other sociodemographic and clinical factors, women were slightly more likely to be counseled, with an adjusted odds ratio (AOR) of 1.15 (95% confidence interval [CI], 1.02-1.29). Physicians counseled older patients (>30 years) more often than younger patients; those aged 40 to 49 years were counseled most often (AOR, 1.71 [95% CI, 1.34-2.20]). Patients with incomes above $50000, those with higher levels of physical activity, college graduates, and patients who were overweight to obese (body mass index: 25 to > or =30 kg/m2) were more likely to be counseled, as were patients with cardiac disease (AOR, 1.81 [95% CI, 1.52-2.14]) and diabetes (AOR, 1.87 [95% CI, 1.46-2.38]). Counseling did not vary by physician specialty or patient race.The rate of physician counseling about exercise is low nationally. Physicians appear to counsel as secondary prevention and are less likely to counsel patients at risk for obesity. The failure to counsel younger, disease-free adults and those from lower socioeconomic groups may represent important missed opportunities for primary prevention.
The Forensic Pathologist: "Family Physician" to the Bereaved
Authors: Robert D. Gillette
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Lester Adelson, MD, (237:1585) is to be commended for pointing out the need for humanism in the relationship between the forensic pathologist and the families of the recently-deceased people he examines. There is no group of people for whom sympathetic listening and intelligent explanation are more important. Careful handling of these matters by the pathologist can prevent much unnecessary suffering by the bereaved, and Dr Adelson's contribution is welcome. We must, however, take exception to the use of the term "family physician" in this context. The rediscovery of the need for continuing, comprehensive, family-centered medical care represents a definite step forward, but we family physicians are now in danger of being loved to death. The crisis management techniques advocated by Dr Adelson, desirable as they may be, are in no way comparable to the continuing care provided by family physicians. We must also challenge the assumption that
Lumleian Lectures ON SOME FORMS OF VOMITING IN INFANCY: Delivered before the Royal College of Physicians of London, March-April, 1925
Authors: H. C. Cameron
Journal: BMJ (1925)

are not very promising, thougli clin-ical results, as published in Feldt's monograph in 1923, are certaiily vboth hopeful and inspiring.COONa O S.Au