tbuckley/cabot-search huggingface dataset:
ROLE OF HYPNOSIS IN DIFFERENTIATION OF EPILEPTIC FROM CONVULSIVE-LIKE SEIZURES
Authors: DONALD B. PETERSON, JOHN W. SUMNER, GORDON A. JONES
Journal: American Journal of Psychiatry (1950)

The differential diagnosis of idiopathic epilepsy from psychogenic seizures was discussed from the points of view of difficulty of diagnosis, inadequacy of differentiating data, and the benefit of exact diagnosis to the patient and the taxpayer. An analysis was made of 65 cases of convulsive disorder, who were subjected to investigation with hypnosis, EEG, and thorough organic study. There were 30 cases of idiopathic epilepsy and 35 of psychogenic seizure. The analysis indicated that investigation under hypnosis with especial reference to whether or not the patient recalled the details of his seizures was of differential diagnostic value.
Academics and scientists
Authors: D. Bulmer
Journal: BMJ (1977)

A zero value had been found in all cases before tamoxifen treatment, but after tamoxifen the index regularly increased to values between 10 and 300%, reaching 500% or more in four cases and 800 in one.This effect has not previously been described in humans.The smears returned to an atrophic pattern within two months after tamoxifen withdrawal.
Abstract IA3: PI3K inhibitors in ER+ breast cancer: Next steps
Authors: Matthew J. Ellis, Robert Crowder, Cynthia X. Ma
Journal: Clinical Cancer Research (2012)

Abstract Gain and loss of function mutations in the PI3 kinase pathway are extremely common in breast cancer and can be seen in all five intrinsic subtypes (Luminal A, Luminal B, HER2+, Basal-like and Claudin Low). However there is a subtype-selective spectrum of activation events including gain of kinase mutations/amplifications (e.g. PIK3CA, HER2 and AKT1) and loss of negative regulators (e.g.PTEN, INPP4B and PIK3R 1). These lesions must be matched to a large number of agents in development that target PI3K, AKT and mTOR. These agents have variable specificities, toxicities, pharmacokinetics and administration routes which affect the development of combinations with standard therapies and also with each other. In keeping with very broad clinical opportunities, positive findings in preclinical models in both luminal and basal-like breast cancer will be presented. Ongoing clinical trial designs will also be discussed and biomarker approaches for patient selection and stratification will be considered.
Department of Health lists indicators for healthcare professionals to use in quality accounts
Authors: J. Wise
Journal: BMJ (2009)

The Department of Health and the NHS Information Centre have published 232 quality indicators that healthcare professionals working for the NHS in England can use to assess their performance in the accounts of quality that they will be required to publish from next year.

The aim is for doctors to select the indicators that are most relevant to their work and to use these as benchmarks to measure quality of care. The Department of Health states that these are not compulsory indicators for performance management, but it is possible that some might be specified as core indicators to be used in quality accounts.

From April 2010 all healthcare providers working for, or on behalf of, the NHS in England will need to publish quality accounts just as they publish financial accounts.

Announcing the quality indicators, the health minister Ara Darzi said, “This initial list is just the start of an NHS-wide resource that will challenge and stimulate NHS staff to drive …
Interstitial pulmonary fibrosis with and without associated collagen vascular disease: results of a two year follow up.
Authors: C Agusti, A Xaubet, J Roca, A G Agusti, R Rodriguez-Roisin
Journal: Thorax (1992)

BACKGROUND: Interstitial pulmonary fibrosis is a disease with a highly variable clinical course. To ascertain if an inadequate selection of patients might explain part of this variability, two different groups of patients with interstitial pulmonary fibrosis, those with the "lone" form of the disease (LIPF) and those with associated collagen vascular disorders (AIPF), were studied separately. METHODS: Twenty consecutive patients (nine with LIPF and 11 with AIPF) were included. Their clinical and radiographic findings and results of pulmonary function tests, gallium-67 lung scanning, and cellular analysis of bronchoalveolar lavage fluid were compared at diagnosis. Moreover, the evolution of LIPF and AIPF was contrasted after a follow up of two years, both groups having received a similar treatment regimen of corticosteroids. RESULTS: At enrollment, patients with LIPF and AIPF were of similar age, and had similar symptoms and derangement of lung function, but patients with LIPF presented with finger clubbing, more obvious radiographic abnormalities, and a greater percentage of eosinophils in bronchoalveolar lavage fluid. Two years later, patients with LIPF had significantly decreased FVC, FEV1, TLC, TLCO, and PaO2. By contrast, lung function remained unaltered in patients with AIPF. Similarly, when the percentage change from entry to the study was compared, patients with LIPF showed a significant decrease in FVC, FEV1, and PaO2. CONCLUSIONS: Unlike the patients with AIPF, those with LIPF showed a deterioration in lung function and developed further restrictive impairment and poorer gas exchange. This has implications in their clinical management.
The Role of the Primary Physician in Disability Determination for Social Security Insurance and Workers' Compensation
Authors: Timothy S. Carey, Nortin M. Hadler
Journal: Annals of Internal Medicine (1986)

Primary care physicians frequently are asked to serve as advisors, objective third-party examiners, patient advocates, or adjudicators in different work disability programs, or serve at various functions within the same program. The two largest disability programs are Social Security Disability Insurance and Workers' Compensation. Social Security programs are nationally uniform, based on set criteria, and do not require the applicant to show the cause of his or her impairment. Workers' compensation programs differ from state to state and require that the injury or illness occurred as a result of employment. Physicians are often asked to assess impairment or causality on the basis of incomplete information. Improved awareness of the limitations of our scientific knowledge regarding work disability, and the roles physicians play in the disability process, may reduce frustration for physician and patient.
Demonstration of Microorganisms and Dust in Schools and Offices
Authors: S. Gravesen, L. Larsen, F. Gyntelberg, P. Skov
Journal: Allergy (1986)

"The sick-building syndrome" (WHO) is reported with increasing intensity in non-industrial places of work, such as schools, kindergartens, and offices, all of which have a heavy load of traffic (people). The construction of these buildings (e.g. flat roofs) often leads to water damage with subsequent microbial growth. Further, reduced cleaning budgets in connection with the wide use of needle-felt carpets, as well as ventilation systems not regularly maintained, will lead to pollution by dust and microorganisms. A systematic registration of dust and microbial parameters has been carried out since 1980 in buildings with indoor climate complaints, in order to elucidate the possible influence of these factors.
Consolidation enhancement: Which stages of sleep for which tasks?
Authors: Carlyle T. Smith
Journal: Behavioral and Brain Sciences (2005)

The Walker model raises a number of questions, particularly about the nature of the sleep states involved in consolidation enhancement. While REM sleep, Stage 2 sleep, and Stage 3/4 sleep have been implicated in procedural learning, we still do not understand which types of learning are involved with specific sleep states. Several possible ideas for future research are suggested.
Accuracy of a composite score using daily SAPS II and LOD scores for predicting hospital mortality in ICU patients hospitalized for more than 72 h
Authors: J. Timsit, J. Fosse, G. Troché, A. De Lassence, C. Alberti, M. Garrouste-Orgeas, E. Azoulay, S. Chevret, P. Moine, Y. Cohen
Journal: Intensive Care Medicine (2001)
Papuloerythroderma of Ofuji in a HIV-infected patient
Authors: E.R. Lonnee, J. Toonstra, S.C.J. van der
           Putte, H. van
           Weelden, W.A. van
           Vloten
Journal: British Journal of Dermatology (1996)

Journal Article Papuloerythroderma of Ofuji in a HIV‐infected patient Get access E.R. Lonnee, E.R. Lonnee Department of Dermatology, University Hospital Utrecht, Utrecht, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar J. Toonstra, J. Toonstra Department of Dermatology, University Hospital Utrecht, Utrecht, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar S.C.J. van der Putte, S.C.J. van der Putte Department of Pathology, University Hospital Utrecht, Utrecht, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar H. van Weelden, H. van Weelden Department of Dermatology, University Hospital Utrecht, Utrecht, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar W.A. van Vloten W.A. van Vloten Department of Dermatology, University Hospital Utrecht, Utrecht, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 135, Issue 3, 1 September 1996, Page 500, https://doi.org/10.1111/j.1365-2133.1996.tb01536.x Published: 01 September 1996
A recipe for disaster?
Authors: A. C. K. Lee
Journal: BMJ (2010)

Commissioning by consortiums of general practitioners (GPs) looks like a recipe for disaster for both patients and GPs.1 2

All general practices will be compulsorily involved in commissioning but most GPs lack the appropriate management skills, training, or experience.3 Whether it is appropriate and cost effective to use limited clinician time in this way is questionable, and …
Prevalence, screening and treatment of latent tuberculosis among oral corticosteroid recipients
Authors: Nicholas T Vozoris, Julie Seemangal, Jane Batt
Journal: European Respiratory Journal (2014)

To the Editor: 

Tuberculosis guidelines identify individuals receiving the corticosteroid drug prednisone (or its equivalent) at a dose of >15 mg·day−1 for 2–4 weeks or more as a group at risk of tuberculosis if infected with Mycobacterium tuberculosis [1, 2]. There is an eight-fold increased risk of developing active tuberculosis with such drugs at this dose [3]. However, there is no information on the epidemiology of latent tuberculosis infection (LTBI), screening and treatment among oral corticosteroid users. Tuberculosis guidelines recommend using a threshold of ≥5 mm induration to identify latent infection among oral corticosteroid recipients [1, 2] but this recommendation is not evidence-based. The purpose of this study was to describe the prevalence, screening and treatment of LTBI among oral corticosteroid recipients in the USA.

This was a cross-sectional study using US nationally representative, population-level data from the 1999–2000 National Health and Nutrition Examination Survey (NHANES). A description of the survey design and methodology appears elsewhere [4]. Self-reported medication receipt within the past month that required a prescription was collected by NHANES. Medication receipt was confirmed in 83.3% of participants through examiner inspection of prescription containers [5]. Survey participants who received any corticosteroid in an oral formulation within the past month were considered “recipients”. Survey participants who did not receive any oral corticosteroids within the past month were considered “nonrecipients”. Topical, inhaled or intra-articular corticosteroids were not included in this study. Information on total duration of corticosteroid receipt was collected but not dose. A single-step tuberculin skin test (TST) …
SKIN ERUPTIONS DUE TO THE LOCAL APPLICATION OF SULPHONAMIDES
Authors: G. A. GRANT PETERKIN
Journal: British Journal of Dermatology (1945)

Journal Article SKIN ERUPTIONS DUE TO THE LOCAL APPLICATION OF SULPHONAMIDES Get access G. A. GRANT PETERKIN G. A. GRANT PETERKIN Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 57, Issue 1-2, 1 January 1945, Pages 1–9, https://doi.org/10.1111/j.1365-2133.1945.tb11182.x Published: 01 January 1945
Management of primary biliary cirrhosis
Authors: Jenny E. Heathcote
Journal: Hepatology (2000)

Primary biliary cirrhosis (PBC) is a presumed autoimmune disease of the liver, which predominantly affects women once over the age of 20 years. Most cases are diagnosed when asymptomatic (60%). The antimitochondrial antibody is present in serum in most, but not in all, patients with PBC. The disease generally progresses slowly but survival is less than an age- and gender-matched general population. The symptomatic patient may have fatigue, generalized pruritus, portal hypertension, osteoporosis, skin xanthomata, fat soluble vitamin deficiencies, and/or recurrent asymptomatic urinary tract infections. Many nonhepatic autoimmune diseases are found in association with PBC and may prompt initial presentation. To date, immunosuppressive therapy has not been shown to prolong survival in PBC. The hydrophilic bile acid, ursodeoxycholic acid (UDCA), has been shown when given in a dose of 13 to 15 mg/kg daily for up to 4 years to delay the time to liver transplantation or death. This therapy also causes a significant improvement of all the biochemical markers of cholestasis but has no beneficial effects on any of the symptoms or associated disorders. Treatment with UDCA does not obviate the need for liver transplantation. Therapies to prevent complications arising from malabsorption, portal hypertension, and/or osteoporosis are required as well. Good control of pruritus can be achieved in most patients. PBC is diagnosed with increasing frequency, but the agent(s) responsible for this slowly progressive destruction of the interlobular bile ducts remains elusive and hence a specific therapy remains unavailable.
Lack of Inertia Force of Late Systolic Aortic Flow Is a Cause of Left Ventricular Isolated Diastolic Dysfunction in Patients With Coronary Artery Disease
Authors: Takayuki Yoshida, Nobuyuki Ohte, Hitomi Narita, Seiichiro Sakata, Kazuaki Wakami, Kaoru Asada, Hiromichi Miyabe, Tomoaki Saeki, Genjiro Kimura
Journal: Journal of the American College of Cardiology (2006)
Push Enteroscopy for Recurrent Gastrointestinal Hemorrhage Due to Jejunal Anastomotic Varices: A Case Report and Review of the Literature
Authors: S.-J. Tang, R. Jutabha, D. M. Jensen
Journal: Endoscopy (2002)

Small-bowel anastomotic and adhesion-related varices can form within adhesions in the setting of mesenteric venous hypertension, arising from either mesenteric venous obstruction or portal hypertension. In evaluating gastrointestinal bleeding in patients who have had previous abdominal surgery and mesenteric venous hypertension, small-bowel anastomotic varices and adhesion-related varices should be considered. For patients with recurrent, severe melena or hematochezia, we recommend that the initial diagnostic work-up should include push enteroscopy in patients with previous small-bowel surgery. Retrograde ileoscopy should also be considered these patients to look for distal small-bowel varices. Potentially, such small-bowel varices can be identified by wireless capsule endoscopy. We report a case of recurrent gastrointestinal bleeding caused by jejunal anastomotic varices which were secondary to superior mesenteric vein occlusion following an abdominal gunshot wound. Although the treatment of segmental varices has been surgical resection, for patients with overt systemic portal hypertension, a transjugular intrahepatic portal-systemic shunt or a decompressive shunting procedure are recommended.
1081-53 Debulking of chronic total occlusions with rotational or directional atherectomy before stenting trial: A multicenter randomized study
Authors: Etsuo Tsuchikane, Takahiko Suzuki, Yasushi Asakura, Osamu Katoh, Hirotaka Oda, Kinzo Ueda, Takahiro Tanaka, Tetsuo Matsubara, Kenshi Fujii, Yung-Sheng Hsu, Hideo Tamai
Journal: Journal of the American College of Cardiology (2004)
Alcoholics' Kin Don't Like Diazepam
Authors: Frederick K. Goodwin
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Einführung in die Kolposkopie
Authors: George W. Corner
Journal: JAMA (1964)

The colposcope, described some 40 years ago by Hinselmann, has long been popular in many European clinics as a method for diagnosing cervical lesions. It has never caught on in this country, largely because it is an expensive and unfamiliar instrument. Furthermore, the development of exfoliative cytology in the 40's provided American gynecologists with a simpler technique for screening large numbers of women.  Recently, however, there has been a revival of interest in the colposcope in this country, not as a tool in cancer detection, but rather as a method for more intimate study of the cervical epithelium in vivo. A number of clinics now use the instrument as a help in evaluating equivocal vaginal smears, and to observe the very earliest changes in the cervix.  This volume is primarily an atlas of colposcopy combined with a moderate number of pages of text describing the technique and the current point
Cerebral Phosphorus-31 magnetic resonance spectroscopy in patients with chronic hepatic encephalopathy
Authors: Simon D. Taylor-Robinson, Janet Sargentoni, Rosemary J. Mallalieu, Jimmy D. Bell, David J. Bryant, Glyn A. Coutts, Marsha Y. Morgan
Journal: Hepatology (1994)

Cerebral phosphorus-31 magnetic resonance spectroscopy was undertaken in 33 patients with biopsy-proven cirrhosis: 6 had no evidence of neuropsychiatric impairment on standard clinical, psychometric and electrophysiological testing; 8 had evidence of subclinical hepatic encephalopathy; and 19 were classified as having overt hepatic encephalopathy. The reference population comprised 15 healthy volunteers. Unlocalized spectra were acquired from the entire head with a 45-degree pulse angle and repetition times of 1 and 5 sec. Spectra localized to the basal ganglia were acquired with a 45-degree pulse angle and a repetition time of 1 sec. Peak area ratios of phosphomonoesters, inorganic phosphate, phosphodiesters and phosphocreatine relative to beta-ATP were measured in the spectra acquired. We noted no consistent change in the ratios of inorganic phosphate to ATP and phosphocreatine to ATP. Mean values of the ratios of phosphomonoesters to ATP and phosphodiesters to ATP were significantly lower in the total patient population than in the reference population, and they correlated with the patients' neuropsychiatric status. Thus we found no significant reductions in the mean ratios of phosphomonoesters to ATP and phosphodiesters to ATP in patients who were neuropsychiatrically unimpaired, but significant reductions were observed in the mean ratios of phosphomonoesters to ATP and phosphodiesters to ATP in patients with both subclinical and overt hepatic encephalopathy. The most marked reductions in these metabolite ratios were observed in patients with overt encephalopathy.
Abnormal Radionuclide Uptake in Pseudomyxoma Peritonei
Authors: KEDAR N. CHINTAPALLI, SHAILENDRA CHOPRA, DARLENE F. METTER
Journal: Clinical Nuclear Medicine (1998)

A case of pseudomyxoma peritonei with increased radionuclide uptake in the abdomen is described. The uptake of the radionuclide was confined to the omentum as confirmed by the CT study of the abdomen and pelvis. The mechanism of uptake and differential diagnosis are discussed.
Infectious and Serum Viral Hepatitis
Authors: Victorino S. T. Barreto
Journal: JAMA (1972)

Serum levels of IgM and thymol turbidity were determined in 31 patients with Australia antigen-negative, documented short-incubation infections with the infectious hepatitis (IH) virus, and 65 patients with Australia antigen-positive, long-incubation serum hepatitis (SH) infections. During the acute phase, IgM and thymol turbidity levels were significantly higher in patients with IH than in those with SH infections. However, the overlap was so great that neither test clearly distinguished between the two groups. Following recovery in both groups, IgM level usually returned to normal, but the thymol turbidity level often remained elevated. Of patients with prolonged active SH hepatitis, only half had raised levels of IgM and thymol turbidity. We conclude that neither the IgM level nor the thymol turbidity level clearly distinguishes between IH and SH infections or provides a reliable index of disease activity.
Slowing the Return of Hypertension After Stopping Medication-Reply
Authors: M. Donald Blaufox
Journal: JAMA (1985)

<h3>In Reply.—</h3> Dr Finnerty asked a very cogent question: "Why wait for five years to discontinue therapy?" By implication, Dr Finnerty is asking about mild hypertensive people who are well controlled on one medication alone. We would agree with the figures he gives for those with well-controlled hypertension with mean diastolic blood pressures of 83 mm Hg. However, we interpret Dr Finnerty's data as being the experience of patients who were treated for 12 months, not six months. Also, some of our patients relapsed long after six months without medication, emphasizing the need for continued surveillance of the patient. We agree with Dr Finnerty that there are strong indications that regression of the hypertensive process may occur with prolonged therapy. We think that the period of treatment needed is probably longer than six months, but less than five years. Also, there are indications that dietary change helps blood pressure control.