tbuckley/cabot-search huggingface dataset:
Maintenance of Certification
Authors: Edward Ringel
Journal: Annals of Internal Medicine (2015)

Letters6 January 2015Maintenance of CertificationEdward Ringel, MDEdward Ringel, MDFrom Maine General Medical Center, Augusta, Maine.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5040-2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Centor and colleagues' editorial (1) is thought-provoking from the perspective of a physician nearing retirement. I'm 61 years old and keep up with the literature, attend conferences, and try my best to apply thoughtful care to my patients. I plan to retire at 65. I have “grandfathered” internal medicine and pulmonary certificates, and I let my critical care certification lapse because, mercifully, I don't do critical care anymore. I did want to participate in MOC so that prospective patients who search the Internet see that I meet this criterion. Meeting MOC requirements is also useful for recredentialing ...Reference1. Centor RM, Fleming DA, Moyer DV. Maintenance of certification: beauty is in the eyes of the beholder [Editorial]. Ann Intern Med. 2014;161:226-7. [PMID: 24821483] doi:10.7326/M14-1014 LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Edward Ringel, MDAffiliations: From Maine General Medical Center, Augusta, Maine.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterest Forms.do?msNum=L14-0498. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMaintenance of Certification: Beauty Is in the Eyes of the Beholder Robert M. Centor , David A. Fleming , and Darilyn V. Moyer Maintenance of Certification Michael Kelley Maintenance of Certification Donald Trainor Maintenance of Certification Robert B. Copeland Maintenance of Certification Leonard Johnson Maintenance of Certification Antoinette Spevetz Maintenance of Certification Robert M. Centor , David A. Fleming , and Darilyn V. Moyer Metrics 6 January 2015Volume 162, Issue 1Page: 77KeywordsConflicts of interestCritical careDisclosureInternetMedical educationPatients ePublished: 6 January 2015 Issue Published: 6 January 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Height at diagnosis of insulin dependent diabetes in patients and their non-diabetic family members.
Authors: T J Songer, R E LaPorte, N Tajima, T J Orchard, B S Rabin, M S Eberhardt, J S Dorman, K J Cruickshanks, D E Cavender, D J Becker
Journal: BMJ (1986)

Height at the onset of insulin dependent diabetes mellitus was evaluated in 200 newly diagnosed children, 187 non-diabetic siblings, and 169 parents. Diabetic children 5-9 years of age at diagnosis were consistently taller than the national average. Non-diabetic siblings of the same age were also tall. Diabetic children aged 14 or over at diagnosis were short, while their siblings and parents were of normal height. Diabetic children positive for islet cell antibodies were taller than those without islet cell antibodies. No association between height and HLA antigens was found. Non-diabetic siblings at high risk for the disease were closer in height to the diabetic children than were the lower risk, non-diabetic siblings. Siblings, particularly those under 10, were also significantly more obese than the general population. Deviations in growth in patients with insulin dependent diabetes mellitus appear to be related to age at diagnosis and a factor(s) not related to parental height.
The Betrayal of Health: The Impact of Nutrition, Environment, and Lifestyle on Illness in America
Authors: Charles B. Arnold
Journal: JAMA (1992)

Muckraking is an established American literary art form. Thus, it is not news that yet another cutting book has been written about the state of the American health environment. In this case it is a work by a former dean of a major school of public health, based on studies funded by two prestigious foundations and offered by an established publisher. Perplexing, though, is that the book contains misinformation, outdated facts, and scientific myths that purport to describe the current health problems of the United States. In addition, it omits much important relevant science. It is surprising to read in a 1991 book, for instance, that "continuously high blood sugar levels can lead to diabetes" (p 19), and (as the final word) that the Framingham study concluded that there is "no suggestion of any relation between diet and the subsequent development of coronary heart disease" (p 75). One learns from
TCT-230 Distal LMCA Lesions Treated with DES and Absorb. The Novel Technique. 30 Day Follow-up
Authors: Andrejs Erglis, Inga Narbute, Sanda Jegere, Dace Sondore, Indulis Kumsars, Ieva Briede, Andis Dombrovskis, Alona Grave, Agnese Knipse, Iveta Mintale
Journal: Journal of the American College of Cardiology (2014)
Abnormal Carotid Artery Structure and Function in Children and Adolescents With Successful Renal Transplantation
Authors: Mark M. Mitsnefes, Thomas R. Kimball, Sandra A. Witt, Betty J. Glascock, Philip R. Khoury, Stephen R. Daniels
Journal: Circulation (2004)

Background— Abnormal carotid artery compliance and increased intima-media thickness (IMT), markers of early atherosclerosis, are prevalent in adults with chronic kidney failure. However, little is known about the extent of these abnormalities in children after transplantation. Methods and Results— Thirty-one children (age, 14.5±4.1 years) with renal transplant (estimated glomerular filtration rate, 78.1±24.5 mL/min per 1.73 m 2 ; range, 44 to 128 mL/min per 1.73 m 2 ) and 33 age- and sex-matched control subjects had ultrasound of the carotid artery, echocardiography, and ambulatory blood pressure monitoring (transplant patients only). IMT was measured, and distensibility and stiffness parameter (β) were calculated to assess carotid artery structure and function. The results were correlated with demographic, clinical, and biochemical variables. Compared with control subjects, children with transplant had higher IMT ( P =0.03) and β ( P &lt;0.0001) and lower distensibility ( P &lt;0.001). In multiple regression analysis, increased IMT in children who had received transplants was associated with higher mean office systolic blood pressure taken within 1 year before the study ( R 2 =0.19, P =0.024) and receipt of &gt;1 transplant ( R 2 =0.16, P =0.02). Worse distensibility and β were significantly associated with higher daytime systolic blood pressure load calculated from ambulatory blood pressure and receipt of cadaveric kidney. When number of antihypertensives was added to the models, only higher number of blood pressure medications independently predicted abnormal distensibility ( R 2 =0.38, P =0.002) and β ( R 2 =0.25, P =0.016). Conclusions— Carotid arteriopathy is present in children with successful renal transplant and is associated with hypertension. The results suggest that these children might be at risk for accelerated atherosclerosis and premature cardiovascular disease.
DIAGNOSTIC PERFORMANCE OF COMPUTED TOMOGRAPHIC CORONARY ANGIOGRAPHY IN PATIENTS WITH END-STAGE RENAL DISEASE
Authors: Mohit Gupta, Borut Jug, Jenny Papazian, Arya Derakhshani, Sheri Koplik, Harpreet Bhatia, Ronald Karlsberg, Matthew Budoff
Journal: Journal of the American College of Cardiology (2011)
Antismoking Efforts by Physicians
Authors: David I. Zeitlin
Journal: JAMA (1983)

<h3>To the Editor.—</h3> I certainly agree with Drs Dismuke and Miller that physicians should share the secrets of good health.<sup>1</sup>However, I think they seriously underestimated physicians' practice in that regard. We conducted a randomized survey of our membership a while back and found that 90% of the 500 persons who responded (out of 1,000 questionnaires sent out) felt a professional obligation to get their smoking patients to stop and their nonsmokers to stay that way. Their antismoking efforts, many of them reported, were a source of tremendous frustration, particularly their attempts to persuade teenaged smokers, including their own, not to smoke. Summing up the prevalent attitude among young smokers, one physician wrote, "Though they have heard a great deal about the hazards of smoking they don't want to give up the immediate pleasure for what may be an eventual problem. Besides, at this stage of their young lives,
Halothane and Oxytocin
Authors: A. M. Hernandez
Journal: BMJ (1964)

ORNAL 571 in the asthmatic condition-namely, the measurement of airway resistance either by the body plethysmograph, the interrupter technique, or by means of plotting flow against transpulmonary pressure during flow.Although these other indices give useful information they are not as practical as the indirect M.B.C. in assessing the change in the asthmatic condition, and anyhow not many people are equipped with body plethysmographs.Asthma by definition means difficult breathing, and in the great majority of the cases of asthma it is simply the " bellows " function of the lungs that becomes impaired.The indirect M.B.C. (or F.E.V.) gives an overall measure of this bellows function whatever the cause of impairment may be, and is now widely used as an index of change in asthma and other lung conditions.-Weare, etc.,
THE ROLE OF THE SYMPTOM IN PSYCHOSOMATIC DISEASE—CHANGES FOLLOWING REMOVAL OF A SYMPTOM BY EXTRAPSYCHIC MEANS
Authors: DANIEL W. BADAL, THOMAS E. DRISCOL, MAXIE MAULTSBY
Journal: American Journal of Psychiatry (1957)

1. Thirty patients with peptic ulcer were interviewed concerning psychoneurotic, psychosomatic, and behavioral symptoms before and after hospital treatment. 2. Many of the patients (21 of 30) showed changes, some profound and some very subtle, ranging from acute hysterical reactions to chronic neurotic invalidism. Unfocussed anxiety occurred in some and some acquired other psychosomatic diseases. 3. The specific changes seem to depend somehow more on the individual's basic conflict and the way in which he has worked the symptom into his pattern of defense rather than on the specific type of medical or surgical treatment, though the dramatic neurotic breakdowns seem to occur mainly after surgery. 4. Cases followed over long periods show that the basic neurotic conflict of the individual determines what will happen in regard to specific symptoms. The outcome of medical or surgical treatment can be predicted only if this basic dynamic unit is known.
Clotting Factor VII (Proconvertin): Synonymy, Properties, Clinical and Clinicolaboratory Aspects
Authors: Benjamin Alexander
Journal: New England Journal of Medicine (1959)

AS has been characteristic of many rapidly developing scientific areas, particularly those concerned with biologic phenomena, the problem of nomenclature in blood coagulation has assumed enormous importance. Workers have been accused of employing a code language that has resulted in confusion to students, internists and even investigators. To obviate this Babel, an international committee was formed in 1954 for the standardization of nomenclature of blood-clotting factors under the chairmanship of Dr. Irving S. Wright, and considerable progress has been made in this direction.Obviously, the problem would be simple if each factor were obtainable free of other clotting factors and . . .
BRAF(V600) Inhibitor GSK2118436 Targeted Inhibition of Mutant BRAF in Cancer Patients Does Not Impair Overall Immune Competency
Authors: David S. Hong, Luis Vence, Gerald Falchook, Laszlo G. Radvanyi, Chengwen Liu, Vicki Goodman, Jeffery J. Legos, Sam Blackman, Antonio Scarmadio, Razelle Kurzrock, Gregory Lizee, Patrick Hwu
Journal: Clinical Cancer Research (2012)

Abstract Purpose: An intact immune system likely contributes to the outcome of treatment and may be important for clearance of drug-resistant tumor cells and for prevention of recurrence. Although pharmacologic inhibition of BRAF(V600E) in melanoma patients, which is linked to immune suppression, results in an initial response rate, these responses are typically of limited duration. Combining immunotherapeutic drugs with kinase-targeted agents is an attractive strategy to increase clinical efficacy. Evidence suggesting that mitogen-activated protein kinase pathway activation in tumor cells contributes to immune suppression suggests that the two approaches may be synergistic, provided that BRAF(V600E) inhibitors are nontoxic to immune cells. Methods: To assess effects of mutant BRAF inhibition on systemic immunity, we studied 13 patients with tumors carrying a BRAF mutation who underwent treatment with GSK2118436, a V600 mutant BRAF-specific inhibitor. We carried out peripheral blood immunomonitoring before and following one or two 28-day cycles of treatment. Results: GSK2118436 treatment had no detectable impact on most immune parameters tested, including serum cytokine levels, peripheral blood cell counts, leukocyte subset frequencies, and memory CD4+ and CD8+ T-cell recall responses. A slight increase in serum TNF-α over the course of treatment was observed. In addition, three of the four human leukocyte antigen-A2–positive patients experienced a modest increase in circulating tumor antigen–specific CD8+ T cells following BRAF(V600) inhibitor therapy. Conclusions: GSK2118436 treatment results in no detectable negative impact on existing systemic immunity or the de novo generation of tumor-specific T cells. These findings suggest that future trials combining specific BRAF(V600E) inhibition with immunotherapy should not impair immune response. Clin Cancer Res; 18(8); 2326–35. ©2012 AACR.
The Aftermath of the Concept of ‘Psychiatric Comorbidity’
Authors: Mario Maj
Journal: Psychotherapy and Psychosomatics (2005)

Editorials| February 23 2005 The Aftermath of the Concept of ‘Psychiatric Comorbidity’ Subject Area: Psychiatry and Psychology Mario Maj Mario Maj Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, Naples, Italy Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (2005) 74 (2): 67–68. https://doi.org/10.1159/000083164 Article history Published Online: February 23 2005 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Mario Maj; The Aftermath of the Concept of ‘Psychiatric Comorbidity’. Psychother Psychosom 1 February 2005; 74 (2): 67–68. https://doi.org/10.1159/000083164 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 2005Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Angiographic Evaluation of Ventricular Function
Authors: Harold T. Dodge
Journal: New England Journal of Medicine (1977)

Angiographic visualization of the left ventricle makes it possible to determine left-ventricular-chamber dimensions, volume, stroke volume, wall thickness, mass and characteristics of regional wall motion. This information is of value for clinical assessment of the performance characteristics of the left ventricle in man with heart disease.Although the original methods for computing leftventricular-chamber volumes were based on biplane filming, and these methods seem to be the most accurate, methods are now available for computing volumes from large films or from cineangiograms taken in single anteroposterior or right-anterior-oblique projections as well. For computing volumes, the most commonly used methods have used . . .
Value of Continuous Photoelectric Recording of Dye Curves in the Estimation of Cardiac Output
Authors: D. W. RICHARDSON, E. M. WYSO, A. M. HECHT, D. P. FITZPATRICK
Journal: Circulation (1959)

In order to test photoelectric recording of dye curves, simultaneous determinations of cardiac output were made in 48 patients with heart disease with the Fick and dye-dilution technics. The dye curves were recorded with a Colson densitometer following either intrathoracic or antecubital injection of dye. Both Evans blue and indocyanine green dyes were employed. Satisfactory agreement was noted between Fick and dye estimates, demonstrating empirically the usefulness of the continuous recording technic.
PM-14 * MODELING GBM IN MICE USING THE CRISPR NUCLEASE SYSTEM TO FUNCTIONALLY VALIDATE NOVEL CANDIDATE DRIVER GENES AND TEST NEW THERAPIES
Authors: B. Moriarity, B. Tschida, D. Largaespada
Journal: Neuro-Oncology (2014)

Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor and has a dismal survival rate of less than 20% in pediatric patients and less than 5% in adults. Identifying and functionally validating driver genes is needed to develop novel therapies to better treat GBM. To this end, we developed a novel method to induce de novo GBM in mice via in vivo gene transfer of the CRISPR nuclease system to functionally validate and/or screen candidate drivers. The CRISPR system is composed of the Cas9 nuclease that uses a RNA guide molecule (gRNA) to identify specific DNA sequences and induce double strand breaks (DSBs). These DSB are repaired by either the error prone process of non-homologous end joining (NHEJ) or perfectly repaired by homologous recombination (HR), allowing the opportunity for gene knockout (KO) or introduction of new sequences into the genome, respectively. To test our system, we utilized information from a pre-validated set of genes shown to induce GBM via in vivo gene transfer of Sleeping Beauty transposons harboring NRASG12V and shTrp53. Thus, Polyethylenimine (PEI) complexed Cas9, Trp53-gRNA, SB100X transposase, and NRASG12V transposon plasmids were injected into the lateral ventricles of neonatal mice and aged for tumor development. Animals injected with Cas9 and Trp53-gRNA or SB100X and NRASG12V alone did not develop tumors whereas all animals receiving both developed rapid onset GBM in 60 ± 16 days. Analysis of the Trp53-gRNA target site from tumors demonstrated clonal frame-shift mutations. These results demonstrate that the CRISPR is highly efficient in vivo to KO gene function. Currently, we are replacing the NRASG12V transposon with the use of HR to incorporate the G12V mutation at the endogenous Nras locus. Future studies will focus on validating candidate GBM driver genes identified from human genomics data and forward genetic screens and attempts to model GBM subgroups.
Ralph Theodore Esterquest (1912–1968)
Authors: John C. Nemiah
Journal: New England Journal of Medicine (1968)

Something about a library breeds anonymity. It is a place for quiet contemplation or lonely discourse with the printed word. The book is the master of the house, and the human reader a shadow only as he goes unobtrusively about his scholarly business. Meetings between friends, ordinarily so warm and loquacious in the world outside, bring only the mute nod of recognition, or the subdued exchange of words uttered sotto voce in guilty anticipation of a reproving "Ssh!" The focus is on books, not men, and it is small wonder that the members of a library staff are ordinarily effaced . . .
INTRACELLULAR FORMS OF POX VIRUSES AS SHOWN BY THE ELECTRON MICROSCOPE (VACCINIA, ECTROMELIA, MOLLUSCUM CONTAGIOSUM)
Authors: William H. Gaylord, Joseph L. Melnick
Journal: The Journal of Experimental Medicine (1953)

The intracellular development of three pox viruses has been studied with the electron microscope using thin sections of infected tissue. Cells infected with vaccinia, ectromelia, and molluscum contagiosum viruses all form developmental bodies preliminary to the production of mature virus. Developmental bodies, believed to be virus precursors, are round to oval, slightly larger than mature virus particles, less dense to electrons, and have a more varied morphology. It is suggested as a working hypothesis that the process of maturation of a virus particle takes place as follows. In the earliest form the developmental bodies appear as hollow spheres, imbedded in a very dense cytoplasmic mass constituting an inclusion body, or in a less dense matrix near the nucleus in cells without typical inclusion bodies. The spheres become filled with a homogeneous material of low electron density. A small, dense granule appears in each developmental body and grows in size at the expense of the low density material. Following growth of the granule, particles are found with the dimensions of mature virus and having complex internal structure resembling bars or dumbells. Mature virus is ovoid and very dense to electrons. An "empty" interior may be found within its thick walls.
Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection
Authors: Eckart Schott, Heiko Witt, Holger Hinrichsen, Konrad Neumann, Viola Weich, Alexandra Bergk, Juliane Halangk, Tobias Müller, Sebastian Tinjala, Gero Puhl, Peter Neuhaus, Bertram Wiedenmann, Thomas Berg
Journal: Journal of Hepatology (2006)
Obesity and Hypertensive Cardiovascular Disease
Authors: M. G. Jameson
Journal: JAMA (1987)

<h3>To the Editor.—</h3> The recent article by Bloom et al<sup>1</sup>entitled "Does Obesity Protect Hypertensives Against Cardiovascular Disease?" has been the topic of recent comment.<sup>2,3</sup>Close scrutiny of their data discloses the genuine possibility that very few of the study subjects were in fact obese. Although no single uniformly accepted definition of obesity or overweight exists, four standard definitions that employ body mass index (BMI) are widely used; BMI equals weight (in kilograms) divided by heightsquared (in square meters). Bray<sup>4</sup>appears to be the only researcher to define both obesity and overweight in terms of BMI. (Other researchers utilize BMI to define only overweight.) Bray defines obesity as a BMI above 30. Table 1 in the article by Bloom et al reports the mean BMI of the highest weight quintile to be 28-3, well under Bray's criterion for obesity. The National Health and Nutrition Examination Survey