The Newer Penicillins
Authors: HAROLD J. SIMON
Journal: Annals of Internal Medicine (1962)

Article1 September 1962The Newer PenicillinsI. Bacteriological and Clinical Pharmacological Investigations with Methicillin and OxacillinHAROLD J. SIMON, M.D., PH.D., LOWELL A. RANTZ, M.D., F.A.C.P.HAROLD J. SIMON, M.D., PH.D.Search for more papers by this author, LOWELL A. RANTZ, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-3-335 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe synthesis of 6-aminopenicillanic acid (1) was followed very quickly by the appearance of several semi-synthetic penicillin homologues. The first of the semi-synthetic penicillins to become widely available after undergoing clinical trials was alpha-phenoxyethyl penicillin (Broxil) (2). The accumulated results of these studies demonstrated that phenoxyethyl penicillin possessed few advantages over alpha-phenoxymethyl penicillin (penicillin V). Its prime importance lay not so much in its antibacterial activities as in the demonstration that clinically active penicillins could now essentially be made to order. A pressing need existed for an agent with the major advantages of penicillin-G—a lack of toxicity, bactericidal efficiency, economy,...References1. BATCHELORDOYLENAYLORROLINSON EPFPJHGN: Synthesis of penicillin: 6-amino-penicillanic acid in penicillin fermentations. Nature (Lond.) 183: 257, 1959. CrossrefMedlineGoogle Scholar2. GARROD LP: The relative antibacterial activity of four penicillins. Brit. Med. J. 2: 1695, 1960. CrossrefMedlineGoogle Scholar3. SIMONRANTZ HJLA: The newer penicillins. II. Clinical experience with methicillin and oxacillin together with comments on their place in antimicrobial therapy. Ann. Intern. Med. 57: 344, 1962. LinkGoogle Scholar4. STEWARTHARRISONHOLT GTPMRJ: Microbiological studies of sodium 6- (2, 6 dimethoxybenzamido) penicillinate monohydrate (BRL 1241) in vitro and in patients. Brit. Med. J. 2: 694, 1960. CrossrefMedlineGoogle Scholar5. RANTZRANTZ LAHH: Sensitivity of various clinically important bacteria to four antibiotics: results obtained with plate-screening method. Stanford Med. Bull. 11: 183, 1953. MedlineGoogle Scholar6. STEWART GT: Changes in sensitivity of staphylococci to methicillin. Brit. Med. J. 1: 863, 1961. CrossrefMedlineGoogle Scholar7. PINDELLBIERWAGENTISCH MHMEDE: Basic pharmacologic studies on penicillin P-12. Abstract of paper presented at Conference on Oxacillin, Hotel Roosevelt, New York City, October 11, 1961. Google Scholar8. KNUDSENROLINSON ETGN: Absorption and excretion of a new antibiotic (BRL 1241). Brit. Med. J. 2: 700, 1960. CrossrefMedlineGoogle Scholar9. MORIGI EM: Personal communication. Google Scholar10. KNOX R: A new penicillin (BRL-1241) active against penicillin-resistant staphylococci. Brit. Med. J. 2: 690, 1960. CrossrefMedlineGoogle Scholar11. Summary of Conference on Oxacillin, Hotel Roosevelt, New York City, October 11, 1961. Google Scholar12. ELEK SD: Staphylococcus Pyogenes and Its Relation to Disease, E. and S. Livingstone, Ltd., London, 1959, p. 455. Google Scholar13. BARBER M: Methicillin-resistant staphylococci. J. Clin. Path. 14: 385, 1961. CrossrefMedlineGoogle Scholar14. MORIGI EM: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Palo Alto, CaliforniaFrom the Division of Infectious Disease, Department of Medicine, Stanford University School of Medicine, Palo Alto, California.These studies were aided by a grant from the National Institute of Allergy and Infectious Disease, National Institutes of Health, United States Public Health Service (E-3371).Dr. Simon is a Fellow of the Arthritis and Rheumatism Foundation.Requests for reprints should be addressed to Harold J. Simon, M.D., Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Palo Alto, California. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHistory of Antibiotics. From Salvarsan to CephalosporinsFlucloxacillin in the treatment of infectious conditions in childrenβ-Lactam Antibiotics: Their Physicochemical Properties and Biological Activities in Relation to StructureMethicillin: Critical Appraisal after a Decade of ExperienceThe Treatment of Infections in Patients with Neoplasia Undergoing SurgeryResistance of Coagulase-Positive Staphylococci to Methicillin and OxacillinThe New Penicillins in EndocarditisAnnotationsLABORATORY EVALUATION OF SEMISYNTHETIC ANTIBIOTICS AGAINST STAPHYLOCOCCI ISOLATED FROM BOVINE UDDEROxacillin Treatment of Severe Staphylococcal InfectionsThe New PenicillinsThe Treatment of Staphylococcal InfectionsThe Diagnosis and Treatment of Bacterial EndocarditisPharmaceutical Sciences—1962. Part IIThe Newer Penicillins II. Clinical Experiences with Methicillin and OxacillinHAROLD J. SIMON, M.D., PH.D., LOWELL A. RANTZ, M.D., F.A.C.P. 1 September 1962Volume 57, Issue 3Page: 335-343KeywordsAllergy and immunologyArthritisClinical trialsInfectious diseasesMedical servicesOral administrationPenicillinPrevention, policy, and public healthStreptococcusToxicity Issue Published: 1 September 1962 CopyrightCopyright ©, 1962, by The American College of PhysiciansPDF DownloadLoading ...