tbuckley/cabot-search huggingface dataset:
STUDIES OF OXYGEN IN THE VENOUS BLOOD
Authors: Christen Lundsgaard
Journal: The Journal of Experimental Medicine (1918)

1. Thirty-one determinations of the total oxygen-combining power and the oxygen in the venous blood from vena mediana cubiti of sixteen resting patients are reported. 2. The difference between the total oxygen capacity of the hemoglobin and the oxygen in the venous blood, the oxygen unsaturation, is calculated. 3. In twelve patients with compensated heart lesions the unsaturation was found within normal limits, between 2.5 and 8 volume per cent. 4. In four patients with incompensated heart disease the values for the unsaturation were all above the normal limit, from 9.7 to 15.2 volume per cent. 5. A general discussion of the problem of interpreting the results is given. 6. A comparison is drawn between the oxygen consumption calculated from direct determination of the blood flow on a normal subject (the writer) and the oxygen unsaturation determined 4 years later on the same subject. A close agreement between the two series of values exists.
FRACTIONAL GASTRIC ANALYSIS IN DISEASES OF THE SKIN: FURTHER OBSERVATION IN 316 CASES, WITH SPECIAL REFERENCE TO ROSACEA
Authors: W. HERBERT BROWN, MARY S. SMITH, ALLISON D. McLACHLAN
Journal: British Journal of Dermatology (1935)

Journal Article FRACTIONAL GASTRIC ANALYSIS IN DISEASES OF THE SKIN: FURTHER OBSERVATION IN 316 CASES, WITH SPECIAL REFERENCE TO ROSACEA Get access W. HERBERT BROWN, M.D., W. HERBERT BROWN, M.D. Physician for Diseases of the Skin, Victoria Infirmary and Royal Hospital for Sick Children, Glasgow; Search for other works by this author on: Oxford Academic Google Scholar MARY S. SMITH, M.D., MARY S. SMITH, M.D. Assistant Physician, Skin Department, Victoria Infirmary and Royal Hospital for Sick Children, Glasgow; Search for other works by this author on: Oxford Academic Google Scholar ALLISON D. McLACHLAN, M.D. ALLISON D. McLACHLAN, M.D. McCall Anderson Lecturer in Dermatology, University of Glasgow; Physician for Disease of the Skin, Western Infirmary and Stobhill, Glasgow Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 47, Issue 5, 1 May 1935, Pages 181–190, https://doi.org/10.1111/j.1365-2133.1935.tb09852.x Published: 01 May 1935
Occupational asthma caused by aromatic herbs
Authors: C. Lemière, A. Cartier, S. B. Lehre, J‐L. Malo
Journal: Allergy (1996)

We describe a subject with occupational asthma caused by several aromatic herbs: thyme, rosemary, bay leaf, and garlic. The diagnosis was confirmed by specific inhalation challenges in the laboratory. Although immediate skin reactivity was demonstrated to the herbs the subject reacted to by inhalation, RAST showed that garlic was the most potent allergen by weight, the other herbs showing less reactivity. These aromatic herbs, bay leaf, thyme, and rosemary, should be included among agents causing occupational asthma in the food industry.
The vibrator Mutation Causes Neurodegeneration via Reduced Expression of PITPα: Positional Complementation Cloning and Extragenic Suppression
Authors: Bruce A Hamilton, Desmond J Smith, Kenneth L Mueller, Anne W Kerrebrock, Roderick T Bronson, Victor van Berkel, Mark J Daly, Leonid Kruglyak, Mary Pat Reeve, Jennifer L Nemhauser, Trevor L Hawkins, Edward M Rubin, Eric S Lander
Journal: Neuron (1997)
THE CULTIVATION OF THE GRANULES OF VACCINIA VIRUS
Authors: E. C. Craciun, E. H. Oppenheimer
Journal: The Journal of Experimental Medicine (1926)

The technique is described whereby vaccinia "granules" are separated from all other material of glycerolated vaccinia calf lymph and cultivated in vitro with embryonic tissues. These "granules"remain alive, as tested by rabbit corneal inoculation, for as long as 71 days, when grown in connection with growing tissue; they fail to remain potent if cultivated with dying cells, showing in this way the same characteristics as whole vaccine virus. The potency of the " granules" increases with the age of the culture under the first mentioned conditions. The fluid part of the vaccinia lymph which remains after the removal of all "granules," is impotent under all conditions.
Treatment of thyroid cancer. Death rates after surgery and after surgery followed by sodium iodide I-131
Authors: V. M. Varma
Journal: JAMA (1970)

A total of 263 patients with histopathologically proved, well-differentiated papillary and follicular thyroid carcinoma were treated with sodium iodide I 131 after surgery. A 100% follow-up was achieved with a mean of 6.3 years, and an observation period of 0 to 20 years. The death rate in these patients was compared with the death rate in 50 patients with papillary and follicular carcinoma of the thyroid treated surgically before introduction of sodium iodide I 131 (control group), and followed for a mean of 6.7 years (0 to 20 years). These groups were matched in sex, but not in age distribution. In patients 40 years of age and older, the group treated with sodium iodide 1131 had a significantly lower death rate than the surgery-only group (P&lt;0.005). There was no significant difference in death rate between patients treated with sodium iodide 1131 and control patients 39 years of age and under.
Experience with itraconazole in cryptococcosis and aspergillosis
Authors: M.A. Viviani, A.M. Tortorano, M. Langer, M. Almaviva, C. Negri, S. Cristina, S. Scoccia, R. De Maria, R. Fiocchi, P. Ferrazzi, A. Goglio, G. Gavazzeni, G. Faggian, R. Rinaldi, P. Cadrobbi
Journal: Journal of Infection (1989)
Staining in Gastrointestinal Endoscopy: The Basics
Authors: None Canto
Journal: Endoscopy (1999)

Chromoendoscopy or tissue staining is an "old" endoscopic technique that has been used for decades. It involves the topical application of stains or pigments to improve localization, characterization, or diagnosis [1]. It is a useful adjunct to endoscopy; the contrast between normally stained and abnormally stained epithelium enables the endoscopist to formulate a diagnosis and/or to direct biopsies based on a specific reaction or enhancement of surface morphology. In recent years, there has been a resurgence of interest in chromoendoscopy as an endoscopic technique that can improve endoscopic diagnosis. This may have occurred because it is a simple, safe, quick, widely available, and inexpensive diagnostic tool. Also, new applications of staining techniques to the diagnosis of conditions such as Barrett's esophagus, celiac sprue, and the presence of Helicobacter pylori underscore the potential for routine clinical use by the gastroenterologist. Vital staining and tattooing have become even more relevant in clinical gastrointestinal practice because of evolving endoscopic therapies (such as endoscopic mucosal resection, photodynamic therapy, multipolar electrocoagulation, etc.) which require careful selection of patients suitable for treatment.
Moving to the moral high ground
Authors: M. Gould
Journal: BMJ (2003)

Jim Johnson, the new chairman of the BMA council, is hoping to move the present “dysfunctional” BMA on to the moral high ground 

The BMA is a “dysfunctional organisation,” which has declined in terms of setting the national health policy agenda and influencing ministers, Jim Johnson, the new chairman of the BMA council, said last week.

Mr Johnson, a consultant vascular surgeon at Halton General Hospital in Cheshire, who was elected last week on the transferable vote system, says the BMA's external relations are at “pretty low ebb.”

In his first interview within just 24 hours of being elected Mr Johnson said that despite the close vote, he could represent all doctors. There was no outright winner in the first ballot of the election. After a complex procedure of redistribution of the minority votes, the outcome was a tie between Mr Johnson and Dr George Rae, a GP. Mr Johnson was elected because he had the highest number of votes on the first round. “I have the mandate as I was elected,” he said.

But he said that internal tension, a rigid 150 year old structure, and the lengthy, and sometimes acrimonious, contract negotiations had seen the BMA's influence wane.

“We have missed out on a great many things because of the amount …
Commentary: Quantitative Models for Lung Cancer Induced by Cigarette Smoke
Authors: Bernard Altshuler
Journal: Environmental Health Perspectives (1989)

This discussion paper gives a limited history of work done at this Institute on quantitative modeling relating to lung cancer and cigarette smoking, a health hazard whose study has been given much encouragement by Norton Nelson.It first starts with the proposal that life shortening be considered as a measure of the impact of lung cancer using log normal and Weibull types of distributions of time to occurrence; second, it con- tinues with an examination of the fits of the log normal and Weibull distributions to the Doll and Hill data on smoking and lung cancer in British physicians and a systematic review and development of mathemati- cal models of carcinogenesis; and third, it reports on the current work that points out inconsistencies in the Armitage-Doll multistage model with the Doll and Hill data and suggests a two-stage clonal growth model that assumes promotion of clonal growth is restricted to cells initiated by the smoke.This proposal and related work support a current trend in risk assessment to adopt a two-stage clonal growth model that incorporates birth and death rates of cells and the transitional probabilities of the stages.
Rapamycin Reverses Chronic Graft Vascular Disease in a Novel Cardiac Allograft Model
Authors: Robert S. Poston, Margaret Billingham, E. Grant Hoyt, Jeffrey Pollard, Randi Shorthouse, Randall E. Morris, Robert C. Robbins
Journal: Circulation (1999)

Background —Chronic graft vascular disease (CGVD) in cardiac allografts has been defined as a slowly evolving vasculopathy unresponsive to conventional immunosuppression. We compared 4 rodent models of CGVD to evaluate the reproducibility of CGVD in heart allografts. Rapamycin (Rapa) and cyclosporine (CSA) were then used to treat CGVD. Methods and Results —Hearts were harvested and placed heterotopically into allogenic recipients. CGVD scores of PVG allografts from ACI recipients treated with CSA on days 1 through 10 were significantly elevated on day 90 (n=16) compared with other models (immunosuppression used): (1) Lewis to F344 recipients (CSA), (2) Brown Norway to Lewis (FK506), and (3) DA to Wistar-Firth (methylprednisolone, azathioprine, CSA). Although delayed (day 60 to 90) CSA treatment had no effect (n=6), delayed Rapa (3 mg · kg −1 · d −1 IP) reversed CGVD in PVG grafts (0.22±0.19 on day 90, n=6). ACI isografts showed no evidence of CGVD (n=6) at day 90. Immunohistochemistry of PVG grafts revealed perivascular infiltrates consisting of CD4 + T cells and limited numbers of macrophages persisting up to day 90. Flow cytometry demonstrated increased levels of anti-donor antibody at day 90, which was significantly inhibited by Rapa treatment. Conclusions —PVG grafts developed a significant increase in CGVD without evidence of ongoing myocardial rejection. This CGVD appeared to be mediated by both cellular and humoral mechanisms, given CD4 + perivascular infiltrates and increased levels of anti-donor antibody. The anti-CGVD effectiveness of Rapa during a period in which there was little myocardial cellular infiltrate supports a novel mechanism of effect such as smooth muscle or B-cell inhibition.
Primary Prevention of Postmenopausal Osteoporosis
Authors: Wendy Levinson
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Urokinase-Targeted Fusion by Oncolytic Sendai Virus Eradicates Orthotopic Glioblastomas by Pronounced Synergy With Interferon-β Gene
Authors: Yuzo Hasegawa, Hiroaki Kinoh, Yasuo Iwadate, Mitsuho Onimaru, Yasuji Ueda, Yui Harada, Satoru Saito, Aki Furuya, Takashi Saegusa, Yosuke Morodomi, Mamoru Hasegawa, Shigeyoshi Saito, Ichio Aoki, Naokatsu Saeki, Yoshikazu Yonemitsu
Journal: Molecular Therapy (2010)

Glioblastoma multiforme (GM), the most frequent primary malignant brain tumor, is highly invasive due to the expression of proteases, including urokinase-type plasminogen activator (uPA). Here, we show the potential of our new and powerful recombinant Sendai virus (rSeV) showing uPA-specific cell-to-cell fusion activity [rSeV/dMFct14 (uPA2), named “BioKnife”] for GM treatment, an effect that was synergistically enhanced by arming BioKnife with the interferon-β (IFN-β) gene. BioKnife killed human GM cell lines efficiently in a uPA-dependent fashion, and this killing was prevented by PA inhibitor-1. Rat gliosarcoma 9L cells expressing both uPA and its functional receptor uPAR (9L-L/R) exhibited high uPA activity on the cellular surface and were highly susceptible to BioKnife. Although parent 9L cells (9L-P) were resistant to BioKnife and to BioKnife expressing IFN-β (BioKnife-IFNβ), cell–cell fusion of 9L-L/R strongly facilitated the expression of IFN-β, and in turn, IFN-β significantly accelerated the fusion activity of BioKnife. A similar synergy was seen in a rat orthotopic brain GM model with 9L-L/R in vivo; therefore, these results suggest that BioKnife-IFNβ may have significant potential to improve the survival of GM patients in a clinical setting. Glioblastoma multiforme (GM), the most frequent primary malignant brain tumor, is highly invasive due to the expression of proteases, including urokinase-type plasminogen activator (uPA). Here, we show the potential of our new and powerful recombinant Sendai virus (rSeV) showing uPA-specific cell-to-cell fusion activity [rSeV/dMFct14 (uPA2), named “BioKnife”] for GM treatment, an effect that was synergistically enhanced by arming BioKnife with the interferon-β (IFN-β) gene. BioKnife killed human GM cell lines efficiently in a uPA-dependent fashion, and this killing was prevented by PA inhibitor-1. Rat gliosarcoma 9L cells expressing both uPA and its functional receptor uPAR (9L-L/R) exhibited high uPA activity on the cellular surface and were highly susceptible to BioKnife. Although parent 9L cells (9L-P) were resistant to BioKnife and to BioKnife expressing IFN-β (BioKnife-IFNβ), cell–cell fusion of 9L-L/R strongly facilitated the expression of IFN-β, and in turn, IFN-β significantly accelerated the fusion activity of BioKnife. A similar synergy was seen in a rat orthotopic brain GM model with 9L-L/R in vivo; therefore, these results suggest that BioKnife-IFNβ may have significant potential to improve the survival of GM patients in a clinical setting.
The Royal Commission Reports
Authors: John Lister
Journal: New England Journal of Medicine (1979)

THE Report of the Royal Commission on the National Health Service1 (NHS) set up in 1976 under the Chairmanship of Sir Alec Merrison, Vice-Chancellor of Bristol University, was published in July. The full report is lengthy, but the recommendations have been summarized in both the Lancet 2 and the British Medical Journal.3 In the opening chapter of the report it is recalled that the commission was set up at a time when there was widespread concern about the future of the NHS. It had been disturbed by the reorganization of 1974, and it was suffering from the effects of a . . .
Ethanolamine Oleate Versus Butyl Cyanoacrylate for Bleeding Gastric Varices: a Nonrandomized Study
Authors: K. Oho, T. Iwao, M. Sumino, A. Toyonaga, K. Tanikawa
Journal: Endoscopy (1995)

Background and Study Aims: Sclerotherapy may be useful in patients with bleeding gastric varices. The aim of this study was to compare the effects of two sclerosants in these patients.
A Damn Bad Business: The NHS Deformed
Authors: B. Salter
Journal: BMJ (1998)

Over the past decade, medicine's leading bodies have been obliged to adjust to the sobering reality that their place in the grand politics of the NHS has changed, and changed permanently. Margaret Thatcher's abrupt exclusion of the profession from the policy making leading up to the 1991 reforms may have been offensive and uncomfortable, but it launched medicine on a political learning curve from which much has been gained. For the future, and with self regulation now a burgeoning issue, continuing political education is a requirement for all medical politicians interested in career advancement.

In this context A Damn Bad Business is a …
TOXEMIA OF PREGNANCY IN THE RABBIT
Authors: Harry S. N. Greene
Journal: The Journal of Experimental Medicine (1937)

The clinical manifestations and pathology of a disorder associated with pregnancy in the rabbit have been described. The disorder bears a close analogy to toxemia of pregnancy in man and offers an experimental approach to the problems associated with that condition. The evidence at hand indicates that the disorder is of endogenous origin and arises from a disturbance of functions concerned in reproductive processes.
The Friendly Professional: Selected Writings of Thurstan Brewin
Authors: L. Fallowfield
Journal: BMJ (1996)

Ed Gareth Rees Eurocommunica, £9.99, pp 154 ISBN 1 898763 05 4

After listening to my exposition on the finer points of teaching doctors how best to communicate with their patients, the professor of oncology in my department politely told me that I had missed the point. He asserted that communication problems were not merely related to the possession of impoverished skills. A far deeper and more serious issue lay at their core; too many doctors did not actually like their patients enough as people. The following day The Friendly Professional arrived on my desk for review.

In this …
Novel pharmacological targets for the treatment of Parkinson's disease
Authors: Anthony H V Schapira, Erwan Bezard, Jonathan Brotchie, Frédéric Calon, Graham L Collingridge, Borris Ferger, Bastian Hengerer, Etienne Hirsch, Peter Jenner, Nicolas Le Novère, José A Obeso, Michael A Schwarzschild, Umberto Spampinato, Giora Davidai
Journal: Nature Reviews Drug Discovery (2006)
Preventing and Treating Bullying and Victimization
Authors: Brenda Bursch
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human Infections: Economic Implications and Prevention
Authors: JOHN V. BENNETT
Journal: Annals of Internal Medicine (1978)

Morbidity and mortality from infectious diseases clearly remain high. Economic assessments should not be based soley on the costs of existing disease but should incorporate costs saved by preventive efforts as well as savings likely to be attained within several years by improved preventive measures. These factors can be used to assess the relative needs for research for specific infections and to compare the economic importance of infections with that of other health problems. Preventive activities for individuals and for larger groups are outlined, and the relation of research to prevention and control of infections is presented.
P411 A SHORTER ESTIMATED DURATION OF INFECTION IN CHINA VERSUS US MAY ACCOUNT FOR THE LOWER PREVALENCE OF HCV-RELATED CIRRHOSIS AND HCC IN CHINA
Authors: H. Raol, E. Wu, S. Fu, B. Feng, R. Fei, A. Lin, M. Chan, R.J. Fontana, L. Wei, A.S. Lok
Journal: Journal of Hepatology (2014)