D-Penicillamine and Lupus Erythematosuslike Syndrome
Authors: THOMAS M. HARKCOM
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 December 1978D-Penicillamine and Lupus Erythematosuslike SyndromeTHOMAS M. HARKCOM, M.D., DOYT L. CONN, M.D., KEITH E. HOLLEY, M.D.THOMAS M. HARKCOM, M.D.Search for more papers by this author, DOYT L. CONN, M.D.Search for more papers by this author, KEITH E. HOLLEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-6-1012_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: D-Penicillamine is being used with increasing frequency in the treatment of rheumatoid arthritis. We describe here the case of a patient who had rheumatoid arthritis in which a syndrome with nephropathy resembling lupus erythematosus (LE) developed after treatment with D-pencillamine.A 32-year-old white woman was initially seen at the Mayo Clinic in May 1976 because of proteinuria. Rheumatoid arthritis had developed, with 4 years of progressive, symmetric polyarthritis, morning stiffness, and decreasing range of motion of the finger joints. Initially, the rheumatoid factor was negative, erythrocyte sedimentation rate was 53 mm/h, and urinalysis findings were normal.After...References1. ELSASHAYSLETTSPARGODURANTROSENBERG LJBJL: Wilson's disease with reversible renal tubular dysfunction. Correlation with proximal tubular ultrastructure. Ann Intern Med 75:427-433, 1971 LinkGoogle Scholar2. HARPEYCAILLEMOULIASGOUST JBRJ: Lupus-like syndrome induced by D-penicillamine in Wilson's disease (letter). Lancet 1:292, 1971 CrossrefMedlineGoogle Scholar3. OLIVERLIBERMANDE VRIES IUA: Lupus-like syndrome induced by penicillamine in cystinuria (letter). JAMA 220:588, 1972 CrossrefMedlineGoogle Scholar4. SCHRAEDERPETERSDAHI PHD: Polymyositis and penicillamine. Arch Neurol 27:456-457, 1972 CrossrefMedlineGoogle Scholar5. DISCHESWINSONHAMILTONPARSONS FDEV: Immunopathology of penicillamine-induced glomerular disease. J Rheumatol 3:145-154, 1976 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Mayo Clinic and Mayo Foundation Rochester, MN 55901 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-Induced DiseaseDRUG AND ENVIRONMENTAL LUPUS: CLINICAL MANIFESTATIONS AND DIFFERENCESDermatomyositis and DrugsSection Review Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Drug-induced lupus: Possible mechanisms and their implications for prediction of which new drugs may induce lupusDRUG-INDUCED LUPUSThe Role of Leukocyte-Generated Reactive Metabolites in the Pathogenesis of Ideosyncratic Drug ReactionsD-penicillamine-induced lupus erythematosusDrug Metabolism by Leukocytes and Its Role in Drug-Induced Lupus and Other Idiosyncratic Drug ReactionsD-penicillamine induced dermopathy in Wilson's diseaseAcetylator Phenotypes in Rheumatoid Arthritis Patients with or without Adverse Drug Reactions to Sodium-Aurothiomalate or d -PenicillaminePenicillamine: Review and cutaneous manifestationsD-Penicillamine-induced pemphigus syndromeAdverse Effects of D-Penicillamine in Rheumatoid ArthritisHOWARD B. STEIN, M.D., A. CAROLINE PATTERSON, M.B., ROBERT C. OFFER, M.D., CHRISTOPHER J. ATKINS, M.B., ALVENA TEUFEL, R.N., HAROLD S. ROBINSON, M.D.Drug-Induced Lupus Erythematosus 1 December 1978Volume 89, Issue 6Page: 1012-1012KeywordsArthritisErythrocyte sedimentation rateLupus erythematosusProteinuriaRheumatoid arthritisStiffness Issue Published: 1 December 1978 PDF downloadLoading ...