Renal-Dose Dopamine: Fact and Fiction
Authors: Harold M. Szerlip
Journal: Annals of Internal Medicine (1991)

Editorials15 July 1991Renal-Dose Dopamine: Fact and FictionHarold M. Szerlip, MDHarold M. Szerlip, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-2-153 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSeriously ill patients commonly show inadequate urine output or deteriorating renal function during a stay in an intensive care unit. When confronted by such events, the critical care specialist often resorts to infusions of dopamine at "renal doses." Accordingly, dopamine has become one of the most commonly used drugs in both medical and surgical intensive care units. It is considered a panacea for oliguria and a mithridate against renal failure. Unfortunately, the mystique that surrounds dopamine's effectiveness in these situations is largely based on anecdotal reports and poorly controlled studies. This is not to say that renal-dose dopamine has no...References1. HorwitzFoxGoldberg DSL. Effects of dopamine in man. Circulation Res. 1962;10:237-43. CrossrefMedlineGoogle Scholar2. McDonaldGoldbergMcNayTuttle RLJE. Effects of dopamine in man: augmentation of sodium excretion, glomerular filtration rate, and renal plasma flow. J Clin Invest. 1964;43:1116-24. CrossrefMedlineGoogle Scholar3. KebabianCalne JD. Multiple receptors for dopamine. Nature. 1979;277:93-6. CrossrefMedlineGoogle Scholar4. SchwartzGewertz LB. The renal response to low dose dopamine. J Surg Res. 1988;45:574-88. CrossrefMedlineGoogle Scholar5. ter WeeSmitRosmanSluiterDonker PAJWJ. Effect of intravenous infusion of low-dose dopamine on renal function in normal individuals and in patients with renal disease. Am J Nephrol. 1986;6:42-6. CrossrefMedlineGoogle Scholar6. OlsenHansenLadefogedFogh-AndersenLeyssac NJSNP. Renal tubular reabsorption of sodium and water during infusion of low-dose dopamine in normal man. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Harold M. Szerlip, MDAffiliations: Philadelphia Veterans Affairs Medical Center University of Pennsylvania School of Medicine Philadelphia, PA 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKidney Function Reserve Capacity in Early and Later Stage Autosomal Dominant Polycystic Kidney DiseaseAcute Kidney Injury (AKI) Clinical Trials: A Critical AppraisalSurgery in the patient with renal diseaseClinical Assessment of Renal FunctionUse of dopamine in acute renal failureEffect of low-dose dopamine on sigmoid colonic intramucosal pH in patients undergoing elective abdominal aortic aneurysm repairRenal-Dose Dopamine: From Hypothesis to Paradigm to Dogma to Myth and, Finally, Superstition?Low-Dose Dopamine: It’s Like Déjà Vu All Over AgainDopamine-1 Receptor Agonist: Renal Effects and Its Potential Role in the Management of Radiocontrast-Induced NephropathyEffects of low-dose dopamine on ventilation in patients with chronic obstructive pulmonary diseaseAcute Renal Failure in the Critically Ill Patient: Is there a Magic Bullet?Acute Renal Failure in the Critically Ill Patient: Is there a Magic Bullet?OliguriaAcute Rental Failure and Dialysis in the Chronically Critically Ill PatientAcute Renal Failure: A Practical UpdateRenal-dose dopamine: will the message now get through?Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trialRenal dose dopamine: Long on conjecture, short on factDie akute respiratorische Insuffizienz im Rahmen des multiplen OrgandysfunktionssyndromsThe renal effect of low-dose dopamine in high-risk patients undergoing coronary angiographyLow-dose dopamine does not prevent acute renal failure in patients with septic shock and oliguriaDirect Effects of Dopamine on Colonic Mucosal pH: Implications for TonometryDiuretic TherapyAcute Renal Failure: Focus on Advances in Acute Tubular NecrosisEdematous StatesEndothelial dysfunction in acute renal failureHemodynamic factors influencing renal blood flowJust how benign is renal dopamine?Circulatory Support, Dopamine, and Dopamine Agonists as Adjuncts to Diuretic TherapyIs the Administration of Dopamine Associated with Adverse or Favorable Outcomes in Acute Renal Failure?IS RENAL DOSE DOPAMINE PROTECTIVE OR THERAPEUTIC? 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