tbuckley/cabot-search huggingface dataset:
Interpersonal Psychotherapy for Somatizing Patients
Authors: Scott Stuart, Russell Noyes Jr.
Journal: Psychotherapy and Psychosomatics (2006)

The interpersonal model is important for understanding somatizing behavior. According to this model, somatizing behavior is a form of interpersonal communication driven by insecure attachment. Interpersonal psychotherapy (IPT) is a time-limited, manual-based treatment designed to relieve symptoms and improve interpersonal functioning. Based on our experience using IPT with somatizing patients, we recommend a series of strategies for its successful implementation. These strategies include an emphasis on the therapeutic alliance within a bilaterally negotiated treatment contract, and aiming for improvement in interpersonal functioning rather than for alleviation of physical symptoms. Specific techniques include the use of bridging metaphors, communication analysis, and genuine positive reinforcement. With a focus on communication in a time-limited frame, fostered by a strong collaborative relationship, IPT appears to be a promising method of reducing somatizing behavior. We urge further research on the efficacy of this form of therapy.
invisible fences of the moral domain
Authors: jonathan haidt
Journal: Behavioral and Brain Sciences (2005)

crossing the border into the moral domain changes moral thinking in two ways: (1) the facts at hand become “anthropocentric” facts not easily open to revision, and (2) moral reasoning is often the servant of moral intuitions, making it difficult for people to challenge their own intuitions. sunstein's argument is sound, but policy makers are likely to resist.
Maggots are useful in treating infected or necrotic wounds
Authors: S Thomas, A. Andrews, M. Jones, J. Church
Journal: BMJ (1999)

EDITOR—In their editorial Wise et al highlight the problems of the development of antibiotic resistant bacteria and outline several strategies to combat this problem.1 We propose another option: the use of fly larvae (maggots) to treat infected or necrotic wounds.

This technique was described in detail in the medical press in the early part of this century …
The Sick Sinus Syndrome
Authors: Jay L. Jordan
Journal: JAMA (1977)

"THE SICK sinus syndrome" is a term coined by Ferrer<sup>1</sup>referring to a constellation of signs, symptoms, and ECG criteria defining sinus node dysfunction in a clinical setting. These criteria, which have been described by many investigators,<sup>2-7</sup>include sinus bradycardia, sinus arrest, sinoatrial block, alternating bradyarrhythmias and tachyarrhythmias, and carotid hypersensitivity. Any one or combination of these features may be seen in the typical sick sinus patient who has syncope or other evidence of cerebral dysfunction. Symptoms, nevertheless, are a manifestation of failure of escape pacemaker function and not truly a feature of sinus node malfunction. <h3>SINUS NODE AS PACEMAKER</h3> The sinus node is a highly organized cluster of specialized cells located in the area of the junction between the superior vena cava and the right atrium. Microscopically, three cell types have been described in the sinus node: P cells, transitional cells, and working cells.<sup>8</sup>The P
Nicotine Stimulates PPARβ/δ Expression in Human Lung Carcinoma Cells through Activation of PI3K/mTOR and Suppression of AP-2α
Authors: XiaoJuan Sun, Jeffrey D. Ritzenthaler, XiaoRong Zhong, Ying Zheng, Jesse Roman, ShouWei Han
Journal: Cancer Research (2009)

Abstract We previously showed that nicotine stimulates non–small cell lung carcinoma (NSCLC) cell proliferation through nicotinic acetylcholine receptor (nAChR)–mediated signals. Activation of peroxisome proliferator–activated receptor β/δ (PPARβ/δ) has also been shown to induce NSCLC cell growth. Here, we explore the potential link between nicotine and PPARβ/δ and report that nicotine increases the expression of PPARβ/δ protein; this effect was blocked by an α7 nAChR antagonist (α-bungarotoxin), by α7 nAChR short interfering RNA, and by inhibitors of phosphatidylinositol 3-kinase (PI3K; wortmannin and LY294002) and mammalian target of rapamycin (mTOR; rapamycin). In contrast, this effect was enhanced by PUN282987, an α7 nAChR agonist. Silencing of PPARβ/δ attenuated the stimulatory effect of nicotine on cell growth, which was overcome by transfection of an exogenous PPARβ/δ expression vector. Of note, nicotine induced complex formation between α7 nAChR and PPARβ/δ protein and increased PPARβ/δ gene promoter activity through inhibition of AP-2α as shown by reduced AP-2α binding using electrophoretic gel mobility shift and chromatin immunoprecipitation assays. In addition, silencing of Sp1 attenuated the effect of nicotine on PPARβ/δ. Collectively, our results show that nicotine increases PPARβ/δ gene expression through α7 nAChR–mediated activation of PI3K/mTOR signals that inhibit AP-2α protein expression and DNA binding activity to the PPARβ/δ gene promoter. Sp1 seems to modulate this process. This study unveils a novel mechanism by which nicotine promotes human lung carcinoma cell growth. [Cancer Res 2009;69(16):6445–53]
405 THE CLINICAL CHARACTERISTICS OF ACUTE KIDNEY INJURY AFTER TRANSARTERIAL CHEMOEMBOLIZATION IN PATIENTS WITH HEPATOCELLULAR CARCINOMA
Authors: J.W. Shin, J. Park, D.M. Kim, J.C. Hwang, M.W. Cho, H.C. Chung, J.S. Lee, N.H. Park
Journal: Journal of Hepatology (2008)
Differential effects of two lots of aroclor 1254 on enzyme induction, thyroid hormones, and oxidative stress.
Authors: D E Burgin, J J Diliberto, E C Derr-Yellin, N Kannan, P R Kodavanti, L S Birnbaum
Journal: Environmental Health Perspectives (2001)

Aroclor 1254 is a commercial mixture of polychlorinated biphenyls (PCBs), which is defined as being 54% chlorine by weight. However, the congener composition varies from lot to lot. Two lots which have been used in toxicity studies, 124-191 and 6024 (AccuStandard), were analyzed for their congener composition. Lot 6024 has approximately 10 times the dioxin toxic equivalents (TEQ) of lot 124-191. The purpose of this study was to determine if the difference in the TEQ of the two lots explains the different in vivo responses seen on a weight basis. Male Long-Evans rats (70 days old) were treated orally with a single dose of 0-1,000 mg/kg of each lot. Hepatic ethoxy-, methoxy-, and pentoxyresorufin O-deethylase (EROD, MROD, and PROD, respectively) activities as well as serum thyroxine (T(4)) concentrations and measures of oxidative stress were determined 4 days after treatment. Results, on a weight basis, indicate that lot 6024 led to a greater induction of EROD, MROD, and PROD but not total T(4) reduction. The differences in TEQ between the lots explained the differential induction of EROD and MROD but did not account for the induction of PROD nor decreases in T(4). PROD induction is not due to dioxin-like congeners, whereas the decrease in serum T(4) levels may involve multiple mechanisms. Effects on the antioxidants ascorbic acid and uric acid were seen only at the highest mass dose for both lots and were not explained by the difference in TEQ. These results illustrate that the differences in the TEQ explain the differences in the strict dioxin-like effects (EROD, MROD induction), but the non-dioxin-like congeners cause other effects that are not associated with the aryl hydrocarbon receptor (e.g., PROD). In addition, supra-additive effects also occur in the mixture (T(4), oxidative stress). Thus, current results demonstrate that overall toxicity cannot be predicted on the basis of the TEQ values. It is also critical that the lot number is reported in studies conducted with Aroclor 1254 because the congener composition and therefore the effects observed can be very different.
Day case surgery and workload.
Authors: J. Boyce, D. Ralphs, B. Devlin
Journal: BMJ (1992)

Mandate for NHS reforms SIR,-Where now for the BMA's policies on the NHS reforms?Concern that a market in health care would result not so much in managerial efficiency and a sensitivity to local needs but in winners and losers with widening gaps in the provision of health care led me to vote Labour.'2Although the general election was not a referendum on the reforms, the high profile of health as a pre-election campaign issue was as near as we are likely to get to one.The return of a Conservative government with a clear working majority means that a public mandate for the NHS reforms has been obtained, and I believe that the BMA should now put its full weight behind them.The purchaser-provider split will become a model not only for the NHS but for a wide range of centrally funded public services.Success in the United Kingdom will ensure that this model is exported to other countries, particularly in the expanding Europe.Recommending an enthusiastic and cooperative approach to the new political situation does not mean that we must cast aside our faculty for criticism.But criticisms must be more sharply focused.If individual patients are disadvantaged the reasons for that disadvantage must be examined rather than assumed and the finger pointed ac- curately at those responsible, be they the provider or the purchasing authority.Cooperation with management must not mean that the political pressure for better funding for the NHS should be abandoned.The exclusion of practising doctors from the management structure must regularly be
In Search of Ondine's Curse
Authors: Oscar Sugar
Journal: JAMA (1978)

A CHRISTMAS Day article in the<i>Chicago Tribune</i>(Dec 25, 1977, pp 1, 26) describes a 16-month-old-child said to be "the only infant known to have beaten Ondine's Curse... a disorder which robs the body of breath." This curse, said the author, was derived from an old German folk tale: Ondine was said to be a sea nymph whose lover betrayed her. To punish him she cursed him with an inability to breathe. Actually, the aforementioned baby is not the only infant to have survived this disorder, which, as a clinical entity, is now well known to respiratory disease specialists, neurosurgeons, and pediatricians. There are, however, many physicians who are not familiar with the syndrome. In this article, I will discuss not the clinical aspects but the origin of the eponym. <h3>The Legend</h3> The term "Ondine's Curse" was first applied to patients by Severinghaus and Mitchell.<sup>1</sup>In 1962 they
An emerging cause of allergic asthma: The jerboa pet
Authors: J.C. Sainz Gutierrez, G. Minguez, J.M. Beitia, C. de Frutos, M. de las Heras, M. de Barrio, T. Herrero, P. Tornero, J.M. Zubeldia, M.L. Baeza, L. Zapatero
Journal: Journal of Allergy and Clinical Immunology (2003)
Surface modification of pancreatic islets using heparin-DOPA conjugate and anti-CD154 mAb for the prolonged survival of intrahepatic transplanted islets in a xenograft model
Authors: Yoon Suk Jung, Jee-Heon Jeong, Simmyung Yook, Bok-Hyeon Im, Jinwon Seo, Sung Woo Hong, Jun-Beom Park, Victor C. Yang, Dong Yun Lee, Youngro Byun
Journal: Biomaterials (2011)
Reduction of complement factor H binding to CLL cells improves the induction of rituximab-mediated complement-dependent cytotoxicity
Authors: S Hörl, Z Bánki, G Huber, A Ejaz, D Windisch, B Muellauer, E Willenbacher, M Steurer, H Stoiber
Journal: Leukemia (2013)

A main effector mechanism of rituximab (RTX) is the induction of complement-dependent cytotoxicity (CDC). However, this effector function is limited, because CLL cells are protected from complement-induced damage by regulators of complement activation (RCAs). A prominent RCA in fluid phase is factor H (fH), which has not been investigated in this context yet. Here, we show that fH binds to CLL cells and that human recombinant fH-derived short-consensus repeat 18–20 (hSCR18–20) interferes with this binding. In complement-based lysis assays, CLL cells from therapy-naive patients were differently susceptible to RTX-induced CDC and were defined as CDC responder or CDC non-responder, respectively. In CDC responders, but notably also in non-responders, hSCR18–20 significantly boosted RTX-induced CDC. Killing of the cells was specific for CD20+ cells, whereas CD20− cells were poorly affected. CDC resistance was independent of expression of the membrane-anchored RCAs CD55 and CD59, although blocking of these RCAs further boosted CDC. Thus, inhibition of fH binding by hSCR18–20 sensitizes CLL cells to CDC and may provide a novel strategy for improving RTX-containing immunochemotherapy of CLL patients.
Biliary Cannulation and Pancreatic Guide-Wire Placement
Authors: M. Saad
Journal: Endoscopy (2004)

I read with interest the article by Maeda et al. on selective biliary cannulation using pancreatic guide-wire placement [1] and the accompanying editorial by Devière [2] in a recent issue of Endoscopy. I strongly support Dr. Devière’s view that we should be reluctant to accept the idea of intentionally cannulating and injecting the pancreatic duct as a method of gaining access to a difficult bile duct.
Syncope associated with supraventricular tachycardia. An expression of tachycardia rate or vasomotor response?
Authors: J W Leitch, G J Klein, R Yee, R A Leather, Y H Kim
Journal: Circulation (1992)

Syncope in patients with supraventricular tachycardia has been suggested to be an ominous finding, predictive of rapid rates during tachycardia.To explore the mechanism of syncope during supraventricular tachycardia, tachycardia was induced in the supine position and after passive head-up tilting to 60 degrees in 13 patients with atrioventricular (AV) node reentry, eight patients with AV reentry, and one patient with atrial tachycardia. Tilt testing was also performed in sinus rhythm for 30 minutes (the last 15 minutes with isoproterenol infusion). Mean +/- SEM age was 38 +/- 3 years, and 11 patients had a history of syncope (median number of syncopal episodes, three; range, one to 30). The cycle length of tachycardia when upright was shorter than when supine (297 +/- 9 compared with 357 +/- 10 msec, p less than 0.001), and mean blood pressure fell to a greater extent after the onset of tachycardia (fall in mean blood pressure, 53 +/- 6 compared with 24 +/- 3 mm Hg, p less than 0.001). Mean blood pressure correlated significantly with tachycardia cycle length when supine (r = 0.58, p = 0.005) but not when tilted upright (r = 0.18, p = 0.45). Syncope occurred in seven patients during upright tachycardia. These seven patients had a greater fall in mean blood pressure with upright tachycardia than the 15 patients without syncope (fall in mean blood pressure, 70 +/- 4 compared with 45 +/- 5 mm Hg, p = 0.01), but there was no difference in the tachycardia cycle length (311 +/- 10 compared with 290 +/- 11 msec, p = 0.29). Six of the seven patients with tachycardia-induced syncope also had syncope with tilt testing in sinus rhythm compared with four of the 15 patients without tachycardia-induced syncope (p = 0.02).These data support the view that syncope during supraventricular tachycardia is related to vasomotor factors and does not predict a more rapid tachycardia rate.
Diagnostic Handbook of Speech Pathology
Authors: Susan S. Laber
Journal: JAMA (1980)

The authors are well known in the area of speech and language pathology, and the information in the book seems valid and reliable. Although their preface states the aim of the book is to provide a "single, complete practical source for the graduate student or practicing clinician," the latter may find that texts less broad in scope are more suited to their needs. However, the organization of the book makes it easily readable. Each chapter begins with a summary of its purpose, and clear headings subdivide the material. Chapters end with examination and interview formats and useful lists of resources, as well as complete references. The appendices present a list of standardized tests and a glossary of terms. I particularly like the authors' eminently practical suggestions, which should prove useful to beginning clinicians. For example, Dr Hutchinson specifies how to structure an examining room. Displaying sensitivity to students, she also
Serum lysozyme in inflammatory bowel disease.
Authors: M W Dronfield, M J Langman
Journal: Gut (1975)

The mean concentrations of serum lysozyme were markedly higher in patients with Crohn9s disease and ulcerative colitis than in normal controls, and mean levels tended to be slightly higher in those with Crohn9s disease than in those with colitis. The significance of these differences is unclear but the overlap between values in normal individuals and those with inflammatory bowel disease prevents the measurement having any discriminant value.
Chickenpox-associated Acute Retinal Necrosis Syndrome
Authors: William W. Culbertson, Roy D. Brod, Harry W. Flynn, Bruce C. Taylor, Bruce A. Brod, David A. Lightman, Gerald Gordon
Journal: Ophthalmology (1991)

Acute retinal necrosis (ARN) syndrome usually occurs as the result of secondary reactivation of latent, previously acquired, varicella-zoster or herpes simplex virus. The authors report four patients who developed a mild form of ARN within 1 month (5 to 28 days) after the onset of chickenpox. In contrast to typical cases of ARN, these cases were less severe, with retinitis limited to two quadrants or less (three patients), no retinal detachment (four patients), minimal vitreitis (four patients), and no loss of visual acuity (four patients). Thus, ARN may occur during the course of primary varicella-zoster infection.
miRSNP-Based Approach Identifies a miRNA That Regulates Prostate-Specific Antigen in an Allele-Specific Manner
Authors: George M. Yousef
Journal: Cancer Discovery (2015)

Abstract Summary: A recent study identified genetic variations within the miRNA response elements of miRNA target genes (miRSNP) that can affect the base paring between miRNAs and their targets, and hence alter miRNA–target interactions. The authors also undertook functional validation studies and were able to demonstrate that overexpression of miR-3162-5p resulted in a 20% decrease in expression of the KLK3 rs1058205 SNP T-allele. Cancer Discov; 5(4); 351–2. ©2015 AACR. See related article by Stegeman et al., p. 368
Detection of Medullary Carcinoma of the Thyroid With I-131 MIBG
Authors: CHRISTOPHER C. THOMAS, ROBERT J. COWAN, DAVID A. ALBERTSON, ROBERT M. COOPER
Journal: Clinical Nuclear Medicine (1994)

Imaging with I-131 MIBG has proved useful for the detection of pheochromocytoma, neuroblastoma, and other neoplasms of neural crest origin. The authors present a case of a patient who was initially diagnosed as having follicular carcinoma of the thyroid in which I-131 MIBG played a key role in leading to the diagnosis of medullary carcinoma of the thyroid. Local and distant metastases were detected using I-131 MIBG imaging. Uptake of I-131 MIBG by medullary carcinoma of the thyroid has both diagnostic and therapeutic implications.
Physicians’ Offices Play Key Role in Promoting Vaccination to Adult Patients
Authors: Rebecca Voelker
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Women's, Children's Health
Authors: Joan Stephenson
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Folinic acid plus 5-FU based chemotherapy in squamous cell carcinoma of the head and neck: Bologna experience
Authors: F. Pannuti, M. Guaraldi, A. Martoni, B. Melotti, M.G. Morritti
Journal: Annals of Oncology (1993)

The principal aim of our policy in the cytotoxic treatment of advanced squamous cell carcinoma of the head and neck (SCCHN) is to reduce toxicity, to maintain or increase the response rate and consequently to improve the quality of life for these patients. In locally advanced disease the aim is to reduce the volume of the tumor and to treat micrometastases in order to achieve a better outcome of the subsequent local treatment (i.e., surgery and/or radiotherapy). In these patients the aim is to prolong survival.We have employed 3 different multi-drug regimens with 5-FU+FA combination in 87 consecutive patients with SCCHN. Two regimens (B1, C) have been used for recurrent and/or metastatic disease and only one (B2) for previously untreated patients with locally advanced SCCHN. Regimen B1: cisplatin (P) 30 mg/m2 i.v., 5-fluorouracil (5-FU) 500 mg/m2 i.v., folinic acid racemic form (d, 1-FA) 200 mg/m2 i.v., bleomycin (B) 15 mg im 1st and 2nd day; Regimen C: P 60 mg/m2 1st day, 5-FU 500-750 mg/m2 continuous infusion, FA 50 mg po every 4 hours, B 15 mg im 2nd and 3rd day; Regimen B2 is similar to the B1 but lasts 3 consecutive days (instead of 2) and for every 3 weeks (instead of 4). It consists of 3 cycles before surgical treatment or radiotherapy.There are no statistical differences in the Objective Response (OR) for the regimens B1 (39%) and C (34%). Grade 3-4 toxicity is higher in regimen B1 (50%) than in regimen C (< or = 8%).Regimen C is less toxic regimen B1 with no significant difference in the OR. The primary treatment study is still ongoing but the preliminary results are promising: the remission rate is 92% (22/24, 1CR + 21 PR) and the median survival is 18 months (range 3-38+).
5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging
Authors: Keith E Szulwach, Xuekun Li, Yujing Li, Chun-Xiao Song, Hao Wu, Qing Dai, Hasan Irier, Anup K Upadhyay, Marla Gearing, Allan I Levey, Aparna Vasanthakumar, Lucy A Godley, Qiang Chang, Xiaodong Cheng, Chuan He, Peng Jin
Journal: Nature Neuroscience (2011)