tbuckley/cabot-search huggingface dataset:
Bone marrow cells recruited through the neuropilin-1 receptor promote arterial formation at the sites of adult neoangiogenesis in mice
Authors: Serena Zacchigna, Lucia Pattarini, Lorena Zentilin, Silvia Moimas, Alessandro Carrer, Milena Sinigaglia, Nikola Arsic, Sabrina Tafuro, Gianfranco Sinagra, Mauro Giacca
Journal: Journal of Clinical Investigation (2008)

Experimental and clinical evidence indicate that bone marrow cells participate in the process of new blood vessel formation. However, the molecular mechanisms underlying their recruitment and their exact role are still elusive. Here, we show that bone marrow cells are recruited to the sites of neoangiogenesis through the neuropilin-1 (NP-1) receptor and that they are essential for the maturation of the activated endothelium and the formation of arteries in mice. By exploiting adeno-associated virus vector–mediated, long-term in vivo gene expression, we show that the 165-aa isoform of VEGF, which both activates the endothelium and recruits NP-1+ myeloid cells, is a powerful arteriogenic agent. In contrast, neither the shortest VEGF121 isoform, which does not bind NP-1 and thus does not recruit bone marrow cells, nor semaphorin 3A, which attracts cells but inhibits endothelial activation, are capable of sustaining arterial formation. Bone marrow myeloid cells are not arteriogenic per se nor are they directly incorporated in the newly formed vasculature, but they contribute to arterial formation through a paracrine effect ensuing in the activation and proliferation of tissue-resident smooth muscle cells.
The Medical Book of Lists: A Primer of Differential Diagnosis in Internal Medicine
Authors: George E. Ehrlich
Journal: JAMA (1984)

It was inevitable that the popular<i>Book of Lists</i>should spawn similar efforts. Besides the many newspapers devoted to such lists, there are now two books of lists for medical doctors. This is<i>The Medical Book of Lists</i>, to be distinguished from the earlier<i>The Physician's Book of Lists (JAMA</i>1984;251:1339). The compilers, from the Kansas University Medical Center (where two served as chief residents; the senior author is the Peter T. Bohan Professor of Medicine) have refined the list method for clinical application. This book grew out of the morning reports, where rapid differential diagnoses were reviewed for the diagnostic problems that arose during the previous 24 hours in the medical wards. Thus, the major problems encountered are addressed, as well as diagnostic studies to establish diagnoses. This is clearly an internist's book; neurology is scanted, only differential diagnosis of coma and of meningitis being included. Surgical problems are
Rapid Eye Movement Sleep Behavior Disorder
Authors: Carlos H. Schenck, Scott R. Bundlie, Andrea L. Patterson, Mark W. Mahowald
Journal: JAMA (1987)

Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia defined by intermittent loss of electromyographic atonia during REM sleep with emergence of complex and vigorous behaviors. Punching, kicking, and leaping from bed during attempted dream enactment caused repeated injury in nine of our first ten adult patients. Mean age at onset was 62 years; nine of the patients were male. All patients underwent standard polysomnographic studies with videotaping of behaviors and extensive neurologic and psychiatric evaluations. The RBD was unrelated to psychopathologic conditions but in five cases was closely linked with major neuropathologic disorders: dementia (two), olivopontocerebellar degeneration, subarachnoid hemorrhage, and the Guillain-Barré syndrome. Other common polysomnographic abnormalities were high REM density, increased stage 3/4 (slow-wave) sleep, and both periodic and aperiodic limb twitching in non-REM sleep. Eight patients had dream changes involving motor overactivity and violent confrontations of dream characters. Clonazepam induced rapid and sustained improvement of dream and sleep behavior problems in seven patients, as did desipramine hydrochloride in one patient.
Enterochromaffin cells in the duodenal mucosa of children with coeliac disease.
Authors: D N Challacombe, K Robertson
Journal: Gut (1977)

A cell counting technique was used to count enterochromaffin (EC) cells in the duodenal mucosa of 10 children with coeliac disease and 10 controls, and significantly greater numbers of EC cells were found in children with coeliac disease. In four children with a clinical history suggestive of coeliac disease, but with minor histopathological changes in the duodenum, gluten challenge resulted in increased numbers of EC cells. Abnormalities of 5-hydroxytryptamine metabolism in coeliac disease may result from hyperplasia of EC cells in the small intestine.
Somatostatin alone or combined with emergency sclerotherapy in the treatment of acute esophageal variceal bleeding: A prospective randomized trial
Authors: Càndid Villanueva, Jordi Ortiz, Miriam Sàbat, Adolfo Gallego, Xavier Torras, German Soriano, Sergio Sáinz, Jaume Boadas, Xavier Cussó, Carlos Guarner, Joaquim Balanzó
Journal: Hepatology (1999)

Recent trials have shown that somatostatin (SMT) is as effective as sclerotherapy in the treatment of acute variceal bleeding and that the combination of both treatments is more effective than sclerotherapy alone. To assess whether the addition of sclerotherapy improves the efficacy of SMT alone, all patients admitted to our unit with gastrointestinal bleeding and with suspected cirrhosis received a continuous infusion of SMT (250 micrograms/h). Endoscopy was performed between 1 and 5 hours later, and patients with esophageal variceal bleeding were randomized to receive or not to receive sclerotherapy. In both groups, SMT infusion was continued for 5 days. Fifty patient admissions were allocated to each group. Therapeutic failure occurred in 21 cases of the SMT group and in 7 cases of the combined-therapy group (P =.002). Failure to control the acute episode occurred in 24% vs. 8% (P =.03) and early rebleeding in 24% vs. 7% (P =.03), respectively. Transfusional requirements were significantly higher in the SMT group, while the incidence of complications was lower (8% vs. 24%; P =.029). In the multivariate analysis, the presence of shock at admission and active bleeding during endoscopy were the variables that better predicted the failure of therapy with SMT alone. Mortality at 6 weeks was similar. These data demonstrate that the addition of sclerotherapy significantly improves the efficacy of SMT alone for the treatment of acute variceal bleeding, although it also increases the rate of complications. Patients with shock and those with active bleeding are more likely to benefit from this combined therapy.
Streptococcus bovis bacteraemia revisited: Clinical and microbiological correlates in a contemporary series of 59 patients
Authors: Mario Fernández-Ruiz, Julia Villar-Silva, Jara Llenas-García, Luis Caurcel-Díaz, Juan Vila-Santos, Francisca Sanz-Sanz, Fernando Chaves, Juan Manuel Guerra-Vales
Journal: Journal of Infection (2010)
Endotoxin and cytokines increase hepatic messenger RNA levels and serum concentrations of apolipoprotein J (clusterin) in Syrian hamsters.
Authors: I Hardardóttir, S T Kunitake, A H Moser, W T Doerrler, J H Rapp, C Grünfeld, K R Feingold
Journal: Journal of Clinical Investigation (1994)

Infection and inflammation induce alterations in hepatic synthesis and plasma concentrations of the acute phase proteins. Our results show that apolipoprotein (apo) J is a positive acute phase protein. Endotoxin (LPS), tumor necrosis factor (TNF), and interleukin (IL)-1 increased hepatic mRNA and serum protein levels of apo J in Syrian hamsters. Hepatic apo J mRNA levels increased 10- to 15-fold with doses of LPS from 0.1 to 100 micrograms/100 g body weight within 4 h and were elevated for > or = 24 h. Serum apo J concentrations were significantly increased by 16 h and further elevated to 3.3 times that of control, 24 h after LPS administration. Serum apo J was associated with high density lipoprotein and increased fivefold in this fraction, after LPS administration. Hepatic apo J mRNA levels increased 3.5- and 4.6-fold, with TNF and IL-1, respectively, and 8.2-fold with a combination of TNF and IL-1. Serum apo J concentrations were increased 2.3-fold by TNF, 79% by IL-1, and 2.9-fold with a combination of TNF and IL-1. These results demonstrate that apo J is a positive acute phase protein.
Pervasive Adaptive Evolution among Interactors of the Drosophila Hybrid Inviability Gene, Nup96
Authors: Daven C. Presgraves, Wolfgang Stephan
Journal: Molecular Biology and Evolution (2006)

Nup96 is involved in a lethal hybrid incompatibility between 2 fruit fly species, Drosophila melanogaster and Drosophila simulans. Recurrent adaptive evolution drove the rapid functional divergence of Nup96 in both the D. melanogaster and the D. simulans lineages. Functional divergence of Nup96 between these 2 species is unexpected as Nup96 encodes part of the Nup107 subcomplex, an architectural component of nuclear pore complexes, the macromolecular channels in nuclear envelopes that mediate nucleocytoplasmic traffic in all eukaryotes. Here we study the evolutionary histories of 5 of Nup96's protein interactors—3 stable Nup107 subcomplex proteins (Nup75, Nup107, and Nup133) and 2 mobile nucleoporins (Nup98 and Nup153)—and show that all 5 have experienced recurrent adaptive evolution. These results are consistent with selection-driven coevolution among molecular interactors within species causing the incidental evolution of incompatible interactions seen in hybrids between species. We suggest that genetic conflict–driven processes may have contributed to the rapid molecular evolution of Nup107 subcomplex genes.
Herpes gestationis: immunopathological and ultrastructural studies*
Authors: CHRISTINE I. HARRINGTON, S.S. BLEEHEN
Journal: British Journal of Dermatology (1979)

Eleven patients with the clinical picture of herpes gestationis were investigated. Biopsies were taken from involved and uninvolved areas of skin and the immunopathological and microscopic changes studied. Direct immunofluorescence showed a deposition of C3 and/or IgG at the basement membrane zone in the involved skin of nine patients and the uninvolved skin of five. Immuno-electron microscopy using a multistep peroxidase antiperoxidase method revealed the in vivo deposition of IgG at the basal plasma cell membrane that extended into the lamina lucida. Light microscopy of urticarial and vesicular lesions showed a marked oedema of the papillary dermis with an inflammatory cell infiltrate that was mainly perivascular. There was spongiosis of the epidermis with oedema and necrosis of the basal cells and in several specimens sub-epidermal clefts with bulla formation. Electron microscopy confirmed the marked degenerative and necrotic changes of the basal cells in the involved areas of skin.
Home Blood Pressure Monitoring
Authors: David J. Magid, Beverly B. Green
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Topical benzoyl peroxide increases the sebum excretion rate in patients with acne
Authors: W. J. CUNLIFFE, C. STAINTON, R. A. FORSTER
Journal: British Journal of Dermatology (1983)

Investigations on fifteen patients with acne showed that at the end of 1 and 2 months of treatment 5% benzoyl peroxide increased the sebum excretion rate by 22.5%. This rise in sebum excretion is probably due to the comedolytic activity of benzoyl peroxide which will influence the pooling of sebum in the upper reaches of the pilosebaceous duct.
Contact sensitivity to toothpaste.
Authors: L G Millard
Journal: BMJ (1973)

Contact Sensitivity to Toothpaste Snt,-I wish to report three cases of acute contact sensitivity to a new toothpaste (Close-Up).Each of these patients changed from their regular toothpaste after receiving a free sample of Close-Up through the post.Case 1.-A 30-year-old woman gave a two- month history of a sore mouth with swelling and cracking of the lips.Two weeks before this developed she changed her toothpaste to Close-Up and used it once or twice a day.She showed fissuring of the lips with desquamation and oedema of the surrounding skin.Case 2.-A 36-year-old man developed a weeping eruption at the right side of the mouth with sore gums.He had used Close-Up once a day for three months.There was a right-sided angular cheilitis with swollen gums and desquamation of the tip of the tongue.Case 3.-A 22-year-old woman used Close-Up three times a day for a week.On the sixth day she developed painful ulcers on the inside of her mouth, particularly inside the lower lip.In each case signs and symptoms settled within one week of stopping the use of the new toothpaste.
The Use of 18F-FDG PET/CT in Cowden Syndrome to Differentiate Multifocal Gastric Carcinoma From Extensive Benign Gastric Polyposis
Authors: William Makis, Anthony Ciarallo, Marc Hickeson
Journal: Clinical Nuclear Medicine (2012)

A 73-year-old man suffering from Cowden syndrome with gastrointestinal polyposis was referred for an 18F-FDG PET/CT after a routine gastroscopic biopsy revealed a poorly differentiated adenocarcinoma. The 18F-FDG PET/CT identified 2 foci of FDG-avid gastric adenocarcinoma on the background of extensive gastric and colorectal polyposis, and correctly staged the disease, which guided management toward a total gastrectomy. This rare case highlights the usefulness of 18F-FDG PET/CT in the staging of gastric malignancy in Cowden syndrome.
Oral Treatment of Polycythaemia Vera with -Naphthyl-di-2-Chloroethylamine
Authors: K. Iversen, E. Meulengracht
Journal: BMJ (1951)

EXPERIMENTAL DIABETES BDICALJOURNAL be controlled by other mechanisms, such as direct or indirect action on tissue metabolism.Experimental medicine has given us most of our funda- mental knowledge of diabetes, and it seems that it will continue to increase this knowledge.It also gives us hope that new methods that will prevent or even cure this disease may be discovered.
Multi-institutional phase 2 study of the farnesyltransferase inhibitor tipifarnib (R115777) in patients with relapsed and refractory lymphomas
Authors: Thomas E. Witzig, Hui Tang, Ivana N. M. Micallef, Stephen M. Ansell, Brian K. Link, David J. Inwards, Luis F. Porrata, Patrick B. Johnston, Joseph P. Colgan, Svetomir N. Markovic, Grzegorz S. Nowakowski, Carrie A. Thompson, Cristine Allmer, Matthew J. Maurer, Mamta Gupta, George Weiner, Ray Hohl, Paul J. Kurtin, Husheng Ding, David Loegering, Paula Schneider, Kevin Peterson, Thomas M. Habermann, Scott H. Kaufmann
Journal: Blood (2011)
TROPICAL ABSCESS OF THE LIVER.
Authors: E. F. ROBINSON
Journal: JAMA (1901)

With the continuous residence of our army in the tropics and the constant return to the United States of scores of invalided soldiers, the subject of tropical diseases has assumed new importance to the medical profession of this country. Probably no subject has been brought so intimately to its attention as that of abscess of the liver. Its relation to dysentery is known, and the frequent development of liver abscess late in the course of this disease explains its appearance so often in the United States. From the earliest times dysentery has been the scourge of armies, but in our own campaign in the Philippines we have had superimposed on the malevolent influences of the massing of great bodies of men together the presence of an endemic disease. The record of the First Reserve Hospital in Manila for one year—March 1, 1899-1900—shows that dysentery and diarrhea were the cause of
Book Reviews; Pharmacology
Authors: J Holiday
Journal: Cardiovascular Research (1992)

Journal Article Book Reviews; Pharmacology Get access J Holiday J Holiday London, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 3, March 1992, Pages 303–304, https://doi.org/10.1093/cvr/26.3.303b Published: 01 March 1992
73. Fully Retargeted Oncolytic Measles Viruses for Cancer Therapy
Authors: Takafumi Nakamura, Mary Harvey, Suzanne Greiner, Kah-Whye Peng, Stephen J. Russell
Journal: Molecular Therapy (2005)

Attenuated replication-competent Edmonston lineage strains of measles virus (MV-Edm) have proven anti-tumor activity against xenograft models of human multiple myeloma, ovarian cancer and glioma. The virus is selectively oncolytic, causing extensive cell to cell fusion via CD46, which is more highly expressed on tumor cells than normal cells. However, MV-Edm retains the capacity to infect a variety of nontransformed cell types via its native receptors, CD46 and SLAM. CD46 is found on all human nucleated cells. SLAM (signaling lymphocyte activation molecule) is only expressed on activated T and B cells, dendritic cells and macrophages. Therefore, the native tropism has possibility to cause immunosupression, unwanted damage to normal tissues, and toxicity of oncolytic measles virus.
Why do medical students choose St Mary's Hospital Medical School?
Authors: J H Baron
Journal: BMJ (1996)

brother, Tempa Tsering, and his family.We remained in touch, and I altered the plans of anyone who was visit- ing Nepal to include a visit to the school.The emphasis is on the education of children in reading, writing, and rehydration.The initial plan had been to educate street children; however, as the school became established, more affluent parents began sending their children and paying fees.These parents objected to the presence of street urchins mingling with their children.Tempa gets around this by taking in the street children during the three month summer break and making them presentable before the school year begins.This compro- mise ensures that the school is almost financially independent and accommodates 220 children, from 4 to 16 years of age.
Shock Reaction Following Ingestion of Mango
Authors: James M. Rubin
Journal: JAMA (1965)

ALLERGIC reactions due to the ingestion of various foods are a well-known occurrence.<sup>1</sup>They can be manifested by rhinitis, bronchial asthma, dermatitis, urticaria, gastrointestinal complaints, migraine, and other symptoms.<sup>2</sup>True anaphylactic-like reactions related to food intake are rarely encountered, but are known to occur. The following case report describes an immediate systemic shock reaction which occurred following the ingestion of mango. A survey of the literature failed to reveal any report of such reaction due to the ingestion of mango. <h3>Report of a Case</h3> A 32-year-old Negro man was first seen in the emergency room of the Jewish Hospital of Brooklyn on Aug 2, 1964, with complaints of itching and tearing of the eyes, swelling of the eyelids, itching of the roof of the mouth, profuse sweating, and tightness of the chest with noisy breathing. The patient stated that he had eaten two slices of peeled mango 30
High incidenceof HBV pred-core gene translation initiation mutations in e antigen-negative patients
Authors: A LARAS
Journal: Hepatology (1995)

Crosslinking of the CD4 coreceptor can inhibit subsequent T-cell activation via the T-cell antigen receptor (TCR)/CD3 complex. The ability of the human immunodeficiency virus (HIV) envelope protein, gp 120, to cause similar inhibition has implicated this inhibitory signal in the induction of T-cell anergy and apoptosis observed in the acquired immunodeficiency syndrome (AIDS). In order to clarify the biochemical basis of this inhibition, we analyzed the effect of CD4 ligation on early signaling events induced by subsequent CD3×CD4 co-crosslinking. By comparison with CD3 crosslinking alone, CD3×CD4 co-crosslinking of a CD3+CD4+ human T-cell leukemia line (SupT1) resulted in an enhanced increase in free intracellular calcium concentration and tyrosine phosphorylation of several cellular substrates, including the prominent phosphorylation of an unidentified 120-kDa protein (p120). Prior CD4 ligation inhibited these responses. Similar results were obtained with A3.01, another CD3+CD4+ T leukemic line. However, p120 was only minor phosporylated on tyrosine upon receptor crosslinking in A2.01/CD4 (-cyt401), a derivative line expressing a truncated CD4 coreceptor lacking its cytoplasmic domain which binds the p56lck protein tyrosine kinase (PTK). Furthermore, prior CD4 ligation failed to inhibit in this line the increased tyrosine phosphorylation induced by subsequent CD3 × CD4 co-crosslinking. Thus, prior CD4 crosslinking, or expression of truncated CD4, are both associated with reduced p 120 phosphorylation. These results suggest that p 120 is a p56lck substrate playing an important role during T-cell activation.
Coactivation of AKT and β-Catenin in Mice Rapidly Induces Formation of Lipogenic Liver Tumors
Authors: Jimmy K. Stauffer, Anthony J. Scarzello, Jesper B. Andersen, Rachel L. De Kluyver, Timothy C. Back, Jonathan M. Weiss, Snorri S. Thorgeirsson, Robert H. Wiltrout
Journal: Cancer Research (2011)

Obesity is a risk factor for development of certain cancers but the basis for this risk is unclear. In this study, we developed a novel mouse model that demonstrates directly how lipogenic phenotypes commonly associated with diet-induced metabolic syndromes can influence hepatic cancer development. Activated AKT and β-catenin (AKT/CAT) genes were hydrodynamically codelivered using the Sleeping Beauty transposon to initiate liver tumorigenesis. AKT/CAT and MET/CAT combination induced microscopic tumor foci by 4 weeks, whereas no tumorigenesis resulted from delivery of AKT, MET, or CAT alone. Primary AKT/CAT tumor cells were steatotic (fatty) hepatocellular adenomas which progressed to hepatocellular carcinomas (HCC) upon in vivo passage, whereas primary MET/CAT tumors emerged directly as frank HCC. Conversion of AKT/CAT tumor cells to frank HCC during passage was associated with induction of the human HCC marker α-fetoprotein and the stem cell marker CD133. Using hierarchical clustering and gene set enrichment analysis, we compared the primary murine AKT/CAT and MET/CAT tumors to a panel of 53 human HCCs and determined that these two mouse models could be stratified as distinct subtypes associated in humans with poor clinical prognosis. The chief molecular networks identified in primary and passaged AKT/CAT tumors were steatosis and lipid metabolic pathways, respectively. Our findings show how coactivation of the AKT and CAT pathways in hepatocytes can efficiently model development of a lipogenic tumor phenotype. Furthermore, we believe that our approach could speed the dissection of microenvironmental factors responsible for driving steatotic-neoplastic transformation to frank carcinoma, through genetic modification of existing immunodefined transgenic models.