tbuckley/cabot-search huggingface dataset:
THE EFFECTS OF RESISTANCE EXERCISES ON THE NITROGEN, PHOSPHORUS, AND CALCIUM METABOLISM OF PATIENTS WITH RHEUMATOID ARTHRITIS 12
Authors: William S. Clark, Arthur L. Watkins, Henrick O. Tonning, Walter Bauer
Journal: Journal of Clinical Investigation (1954)

Muscle weakness and atrophy are common and disabling manifestations of rheumatoid arthritis for which various types of active exercises are usually prescribed.It is well known that active exercises result in substantial increases in muscle mass and power only when performed repeatedly against resistance with considerable physical effort (1).Although physical activity has been reported to have a protein-anabolic effect and cause calcium retention in normal subjects (2, 3), the metabolic responses to exhaustive physical exertion during active rheumatoid arthritis have not been investigated.These studies were undertaken to deter- mine the effects of heavy resistance exercises on nitrogen, phosphorus, and calcium metabolism in patients experiencing exacerbations of this disease.SUBJECTS 1. M. M., a 42-year-old male, noted symptoms of ar- thritis ten years before admission, characterized by pain in the right hip for six months.Eight, six, and four years before admission, he experienced attacks involving the right shoulder, the left shoulder, and feet, respectively.Four months prior to hospitalization, he developed severe, stiffness and pain in the hands, wrists, elbows, shoulders, hips, knees, and ankles.The fingers, wrists, elbows, and knees became swollen, and nodules appeared over the olecranons.He had had anorexia, marked weakness and fatigue, and had lost 30 pounds.His height was 185 cm., weight, 69.0 Kg.; blood pres- sure, 130/80; and temperature, 98.6°F.The liver edge was palpable 5 cm.below the right costal margin.Cervi- cal, axillary, epitrochlear, and inguinal lymph nodes were 1 This is publication number 157 of the Robert W.
Soluble VEGF receptor Flt1: the elusive preeclampsia factor discovered?
Authors: Aernout Luttun, Peter Carmeliet
Journal: Journal of Clinical Investigation (2003)

Notwithstanding these important unresolved questions, the Zhu et al. ( 5) study should open up a new area of investigation as additional studies probe the connections between β 1 -adrenergic receptor-mediated signaling and CaMKII-dependent effects.If future studies support the proposal by Zhu et al., that one of the consequences of prolonged β 1 -adrenergic receptor stimulation is cardiomyocyte cell death via a CaMKII-mediated pathway, it will indeed be an important contribution to our understanding of the pathogenesis of heart failure that will suggest novel therapeutic targets.1.
EVALUATION OF CARDIAC MECHANICS BASED ON ECHOPAC STRAIN ANALYSIS USING 4D ECHOCARDIOGRAPHY
Authors: David J. Sahn, Kacie Amacher, Rosie Bleck, Meihua Zhu, Cole Streiff, Sumito Kimura, Sreyas Ravi, Austin Park, Muhammad Ashraf
Journal: Journal of the American College of Cardiology (2013)
Atypical glucose tolerance curve in dogs
Authors: D F D. Toit, H Reece-Smith, T G Denton, P. J Morris
Journal: BMJ (1980)

Atypical glucose tolerance curve in dogs SIR,-The recent article of Mr Paul McMaster and others (16 February, p 444) gave the results of preoperative and postoperative intravenous glucose tolerance tests in dogs immunosuppressed by cyclosporin A with segmental pancreatic allografts.The results of these tests were highlighted by the presence of an unusually delayed glucose peak occurring at 30 minutes in both the untreated and the allografted dogs.This delayed glucose response was observed after an intravenous injection of 0-5 g glucose per kg body weight.In our experience of 50 intravenous glucose tolerance tests in normal dogs, using a rapid infusion of 05 g glucose per kg body weight, the peak glucose response always occurred five to 10 minutes after the administration of glucose.These results are in agreement with the findings of other workersl-3 who used this dose and mode of administration of glucose.As the beta cells in the pancreatic islets are known to have an instantaneous response to a glucose challenge4 it is of great interest to us to ascertain how the apparently significantly delayed response after a glucose load was achieved.Furthermore, it would be important to know if the use of the drug cyclosporin A may have contributed to the delayed glucose response in the allografted dogs, although this seems unlikely in view of the similar responses found before operation in the same dogs.
“The Battered-Child Syndrome” 50 Years Later
Authors: John M. Leventhal, Richard D. Krugman
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Managed Problem Solving for Antiretroviral Therapy Adherence
Authors: Robert Gross, Scarlett L. Bellamy, Jennifer Chapman, Xiaoyan Han, Jacqueline O’Duor, Steven C. Palmer, Peter S. Houts, James C. Coyne, Brian L. Strom
Journal: JAMA Internal Medicine (2013)

Adherence to antiretroviral therapy is critical to successful treatment of human immunodeficiency virus (HIV). Few interventions have been demonstrated to improve both adherence and virologic outcomes. We sought to determine whether an intervention derived from problem solving theory, Managed Problem Solving (MAPS), would improve antiretroviral outcomes.We conducted a randomized investigator blind trial of MAPS compared with usual care in HIV-1 infected individuals at 3 HIV clinics in Philadelphia, Pennsylvania. Eligible patients had plasma HIV-1 viral loads greater than 1000 copies/mL and were initiating or changing therapy. Managed Problem Solving consists of 4 in-person and 12 telephone-based meetings with a trained interventionist, then monthly follow-up calls for a year. Primary outcome was medication adherence measured using electronic monitors, summarized as fraction of doses taken quarterly over 1 year. Secondary outcome was undetectable HIV viral load over 1 year. We assessed 218 for eligibility, with 190 eligible and 180 enrolled, 91 randomized to MAPS and 89 to usual care. Fifty-six participants were lost to follow-up: 33 in the MAPS group and 23 in usual care group.In primary intention-to-treat analyses, the odds of being in a higher adherence category was 1.78 (95% CI,1.07-2.96) times greater for MAPS than usual care. In secondary analyses, the odds of an undetectable viral load was 1.48 (95% CI, 0.94-2.31) times greater for MAPS than usual care. In as-treated analyses, the effect of MAPS was stronger for both outcomes. There was neither a difference by prior treatment status nor change in effect over time.Managed Problem Solving is an effective antiretroviral adherence intervention over the first year with a new regimen. It was equally effective at improving adherence in treatment experienced and naïve patients and did not lose effect over time. Implementation of MAPS should be strongly considered where resources are available.clinicaltrials.gov Identifier: NCT00130273.
Heart pumps improve survival in patients with severe heart failure
Authors: S. Mayor
Journal: BMJ (2001)

Implanted heart pumps doubled one year survival and significantly improved quality of life in patients with severe heart failure in a three year study reported this week at the American Heart Association scientific sessions in Anaheim, California.

Pump devices have previously been used for a short time while patients waited for heart transplants, but the trial was the first to investigate their use over a prolonged period. The three year study included 129 patients with end stage heart failure (New York Heart Association class IV) who were ineligible for cardiac transplantation …
Withdraw Saatchi's quackery bill
Authors: M. McCartney
Journal: BMJ (2014)

“Innovation” is a lovely word, with shine and goodness at its heart. Health Secretary Jeremy Hunt has said that Maurice Saatchi’s proposed Medical Innovation Bill1 would encourage “a climate where clinical pioneers have the freedom to make breakthroughs in medicine.” It could “lead to major breakthroughs, such as a cure for cancer,” Hunt said, by removing “barriers that prevent innovation which can save and improve lives.”2

This is misguided. Saatchi’s concern is for people with late stage cancer who “receive only the standard procedure . . . the endless repetition of a failed experiment.” The bill seeks to protect those doctors who make “responsible innovation” when most medical opinion would be unsupportive of their proposals.3 In Saatchi’s …
Intravitreous Ganciclovir for Patients Receiving Zidovudine
Authors: Keith Henry, Herbert Cantrill, Mary Ann Kish
Journal: JAMA (1987)

<h3>To the Editor.—</h3> Patients with acquired immunodeficiency syndrome (AIDS) have been recognized to have a high incidence of cytomegalovirus (CMV) retinitis, which is often bilateral.<sup>1</sup>Treatment with ganciclovir producing systemic effects can often improve the retinitis, but long-term maintenance therapy is required. One of the systemic side effects of ganciclovir therapy is bone marrow suppression, which has been noted in 25% to 30% of patients.<sup>2</sup>As highlighted in two recent issues of<i>American Medical News</i>,<sup>3,4</sup>patients who have CMV retinitis and AIDS may be faced with a frightening dilemma. On the one hand, they may qualify for treatment with zidovudine, which may improve their clinical condition and prolong their lives. On the other hand, CMV retinitis can be rapidly progressive and result in blindness. Treatment with ganciclovir producing systemic effects excludes patients from many of the present protocols involving zidovudine. We recently have treated CMV retinitis in
ACUTE INTESTINAL OBSTRUCTION COMPLICATING PREGNANCY: INTESTINAL RESECTION AND RECOVERY
Authors: Stanley W. Imerman
Journal: JAMA (1928)

A multipara, aged 38 at term, complaining of severe abdominal pains, was admitted to the obstetric department of Dr. Joseph Baer, June 8, 1927. The pains, which had started four hours before admission, were located in the upper part of the abdomen and radiated to the right shoulder. She had vomited once. On examination it was evident that these were not labor pains but appeared to be due to a gallbladder colic, and so we were called in consultation. When we first saw the patient she did not appear very sick. Her temperature was 99.6 F., with a leukocytosis of 18,000. The pains were still present in the right hypochondrium, radiating to the back. In the four hours of her stay in the hospital she had not vomited. There was exquisite tenderness over the gallbladder area, and a vague mass could be palpated through the muscle resistance.
Treadmill Exercise and Resistance Training in Patients With Peripheral Arterial Disease With and Without Intermittent Claudication
Authors: Mary M McDermott, Philip Ades, Jack M Guralnik, Alan Dyer, Luigi Ferrucci, Kiang Liu, Miriam Nelson, Donald Lloyd-Jones, Linda Van Horn, Daniel Garside, Melina Kibbe, Kathryn Domanchuk, James H Stein, Yihua Liao, Huimin Tao, David Green, William H Pearce, Joseph R Schneider, David McPherson, Susan T Laing, Walter J McCarthy, Adhir Shroff, Michael H Criqui
Journal: JAMA (2009)

Neither supervised treadmill exercise nor strength training for patients with peripheral arterial disease (PAD) without intermittent claudication have been established as beneficial.
Epigenetic mechanisms silence a disintegrin and metalloprotease 33 expression in bronchial epithelial cells
Authors: Youwen Yang, Hans Michael Haitchi, Julie Cakebread, David Sammut, Anna Harvey, Robert M. Powell, John W. Holloway, Peter Howarth, Stephen T. Holgate, Donna E. Davies
Journal: Journal of Allergy and Clinical Immunology (2008)
North-South research partnerships: the ethics of carrying out research in developing countries
Authors: T. T.-T. Edejer
Journal: BMJ (1999)

The new phase of North-South research collaboration was caught in a snapshot published recently in a popular weekly newsmagazine.1 The picture is that of a participant in an AIDS study in Guatemala City. He looks jaunty, even confident. In 1997, he participated in a “life-and-death lottery,” as the article is entitled, and beat the odds to be entered into a Merck drug trial of different doses of a triple cocktail containing their new drug, Crixivan. He was one of only 59 patients who were lucky enough to be entered into a trial, among the many who join the “scramble for cutting edge medications in a country where there aren't nearly enough of them to go around.” The clinic caring for him “takes up the slack—for example, by enlisting its patients in drug studies.”

“I felt myself stabilizing [he said]. I had the energy to go back to work.” However, his future, as well as the futures of the rest of the participants who participated in and benefited from the study, is uncertain. “The year long study ended last September, and the leftover medicine will run out in the fall. Participants say they were led to believe that the company would supply them the drugs for the rest of their lives. Merck and the clinic doctors say the only promise was that the company would try to offer more drugs after the study, and the company did agree to provide Crixivan for five years But the patients have to come up with the other two components of the cocktail on their own. That won't be easy. Participants worry that if they go off the drugs the virus will emerge stronger and more resistant to the drugs.”

#### Summary points

North-South research collaboration is currently plagued by differing interpretations of ethical standards of doing …
Allied Health Education and Accreditation
Authors: G C Gupta, H L Hedrick
Journal: JAMA (1990)

<h3>STRUCTURE AND FUNCTION OF THE COMMITTEE ON ALLIED HEALTH EDUCATION AND ACCREDITATION</h3> For more than 50 years, the American Medical Association (AMA) and its members have recognized the value of actively participating in and promoting quality education for allied health personnel. This participation is increasingly important as it becomes more difficult to maintain an adequate supply of qualified professionals who complement, facilitate, or assist physicians as they provide health care services to the public. The history of specific AMA activities related to allied health education and accreditation is recorded in pastMedical Educationissues of<i>The Journal of the American Medical Association</i>. The current era began in 1976 with the establishment of the AMA Committee on Allied Health Education and Accreditation (CAHEA), a 14-member accrediting body staffed by the Division of Allied Health Education and Accreditation (DAHEA) and its three departments. The membership of CAHEA reflects the communities that hold
Intrauterine growth retardation in Iowa communities with herbicide-contaminated drinking water supplies.
Authors: R Munger, P Isacson, S Hu, T Burns, J Hanson, C F Lynch, K Cherryholmes, P Van Dorpe, W J Hausler
Journal: Environmental Health Perspectives (1997)

In a statewide survey of 856 Iowa municipal drinking water supplies in 1986-1987 the Rathbun rural water system was found to contain elevated levels of triazine herbicides. Rates of low birth weight, prematurity, and intrauterine growth retardation (IUGR) in live singleton births during the period 1984-1990 by women living in 13 communities served by the Rathbun water system were compared to other communities of similar size in the same Iowa counties. The Rathbun communities had a greater risk of IUGR than southern Iowa communities with other surface sources of drinking water (relative risk = 1.8; 95% CI = 1.3, 2.7). Multiple linear regression analyses revealed that levels of the herbicides atrazine, metolachlor, and cyanzinc were each significant predictors of community IUGR rates in southern Iowa after controlling for several potentially confounding factors including maternal smoking and socioeconomic variables. The association with IUGR was strongest for atrazine, but all three herbicides were intercorrelated and the independent contributions of each to IUGR risk could not be determined. We conclude that communities in southern Iowa with drinking water supplies contaminated with herbicides have elevated rates of IUGR compared to neighboring communities with different water supplies. Because of the limitations of the ecologic design of this study, including aggregate rather than individual measures of exposure and limited ability to control for confounding factors related to source of drinking water and risk of IUGR, a strong causal relationship between any specific water contaminant and risk of IUGR cannot yet be inferred. The association between the water supplied to the Rathbun communities and the increased risk of IUGR should be considered a preliminary finding that needs to be verified by more detailed epidemiologic studies.
The Harm in Looking
Authors: Alan R. Schroeder, Rita F. Redberg
Journal: JAMA Pediatrics (2013)

As a result of the recent growth in the field of diagnostic imaging, the US population has been subjected to a 7-fold increase in exposure to medical radiation since the 1980s.1 Concerns over radiation-induced malignancy continue to mount in the popular2,3 and scientific4-7 press.
788 CD1D-RESTRICTED NATURAL KILLER T CELLS MODULATE SUSCEPTIBILITY TO DIETARY-INDUCED STEATOHEPATITIS IN MICE
Authors: K. Ikejima, H. Yamagata, S. Ishikawa, K. Arai, T. Aoyama, K. Kon, K. Takeda, S. Watanabe
Journal: Journal of Hepatology (2010)
Immunomodulatory effect of the antiasthma Chinese herbal formula MSSM-002 on TH2 cells
Authors: Kamal Srivastava, Ariel A. Teper, Teng-Fei Zhang, Side Li, Martin J. Walsh, Chih-Kang Huang, Meyer Kattan, Brian H. Schofield, Hugh A. Sampson, Xiu-Min Li
Journal: Journal of Allergy and Clinical Immunology (2004)
Risk of cervical cancer associated with mild dyskaryosis.
Authors: J. H. Robertson, B. E. Woodend, E. H. Crozier, J. Hutchinson
Journal: BMJ (1988)

In a survey of 1781 patients who had mild dyskaryosis in a cervical smear taken between 1965 and 1984 invasive cancer occurred in 10 women. In four cancer was diagnosed soon after presentation, and in three it developed some years after default from follow up. Invasion occurred in one patient during cytological surveillance and in a further two after referral for colposcopic supervision. A poor correlation was found between a single cervical smear showing mild dyskaryosis and biopsy results. This was, however, improved by a series of smears. During initial surveillance cervical smear results reverted to normal in 46% of our patients within two years. During longer term follow up none of these patients developed invasive cancer, and life table analysis showed that three quarters had not relapsed after 14 years. We also found no evidence to suggest that preinvasive disease is more rapidly progressive in younger women. Our results indicate that cytological surveillance is acceptably safe provided that biopsy is advised if dyskaryosis persists.
Hamlet's Enemy: Madness and Myth in Hamlet
Authors: Natalie Shainess
Journal: JAMA (1976)

Written with simplicity and clarity, this book deals with important issues and relates them to problems of psychiatric and psychoanalytic insights. With a few exceptions, Lidz has wisely chosen not to contend with the huge body of existing Hamlet criticism and discussion. Hamlet, he declares, directly challenges the psychiatrist's professional acumen. Is Hamlet mad or feigning madness? Are the "symptoms" a manifestation of something else? Lidz, as others have before him, sees Hamlet's ills as stemming from loss and melancholia. The book differs little from previous conceptions of Hamlet the man and of his dynamics and problems. It does not use the extraordinary ambiguity of everything about this play to see deeper, to look afresh. It also carries the long-existing and deep veins of misogyny revealed in the interpretations of the characters of Queen Gertrude and Ophelia. Psychoanalysts have been quick to brand Gertrude a sensuous, incestuous adulteress. Lidz goes
Health promotion in general practice. Well man clinics won't reduce morbidity.
Authors: J T Hart
Journal: BMJ (1993)

<h3>Objectives</h3> Current retrospective cohort study analyses clinical database records of 4792 assisted reproduction procedures to assess the significance of target effectiveness endpoints from a safety perspective. <h3>Methods</h3> Stimulation protocols with urinary, recombinant or combination of both types gonadotrophin preparations are compared according to the following primary endpoints: incidence of ovarian hyperstimulation syndrome (OHSS), cycle cancellation, follicle count, induced estradiol values, clinical pregnancy achieved and cycles reached embryo transfer/freezing. We have investigated the incidence of cases evaluated as 9risky for OHSS9 by secondary efficacy endpoints (exogenous gonadotrophin exposure, luteinising hormone and progesterone values, oocyte yield, eggs with normal maturation). The following statistical methods were applied: descriptive statistics, Mann-Whitney <i>U</i> test, Kruskal-Wallis test, Pearson chi-square test, Fisher9s exact test, binary logistic regression. <h3>Results</h3> Only 16 cases (0.42%) of moderate and delayed OHSS were established. Three hundred and seven (8.6%) stimulation cycles have been cancelled, principally among urinary protocols. Although the clinical pregnancy rate does not differ significantly in compared groups, punctured follicle count, oocyte yield and progesterone level were higher for recombinant preparations, followed by combined and urinary protocols. Follicle count, mean estradiol and luteinising hormone levels are within the 9safe window9 for all investigated groups, associated with minimised risk of stimulation cancellation. The mean follicle-stimulating hormone (FSH) dose was highest in urinary protocols at the same duration of stimulation compared with recombinant products. The younger age, bigger follicle count, oocytes yield, mature oocytes count, percentage of fertilised oocytes, more embryos transferred and the later day of embryo transfer are critical for both assisted reproduction techniques (ART) success rate and the safety profile of sterility treatment. <h3>Conclusions</h3> Safety surveillance of ART exceeds the incidence of OHSS. Suboptimal effectiveness of stimulation protocols may also jeopardise the well-being of ART patients. Gonadotrophin exposure, induced values of sex hormones, and quantity and quality of extracted oocytes should be considered to minimise any unintended suffering of treated couples.