tbuckley/cabot-search huggingface dataset:
A novel mediterranean “δβ‐thalassemia” determinant containing the δ<sup>+</sup>27 and β°39 point mutations in cis
Authors: Lina Oggiano, Luciana Guiso, Laura Frogheri, Georgios Loudianos, Paola Pistidda, Elena Rimini, Mario Pirastu, Antonio Cao, Maurizio Longinotti
Journal: American Journal of Hematology (1994)

The term delta beta-thalassemia with normal HbF has been recently proposed to define heterogenous delta and beta globin gene molecular defects involving the same chromosome in cis. Here, we describe a Sardinian family in which three members showing microcytosis, border-line HbA2 levels and normal HbF proved to be heterozygotes for delta(+) 27 and beta(0) 39 point mutations in cis by allele specific oligonucleotide hybridization as well as by ECO 0 109 I endonuclease digestion and electrophoresis. As some of these beta-thalassemia carriers shows normal HbA2 levels, knowledge of the molecular basis of this novel delta beta-thalassemia silent phenotype would be useful in thalassemia screening and genetic counselling.
Acute Meningoencephalitis After Withdrawal of Antibiotics in Whipple's Disease
Authors: MARK FELDMAN
Journal: Annals of Internal Medicine (1980)

A man with Whipple's disease was treated with oral penicillin (500 mg twice a day) for 2 years with eradication of bacillary organisms from the jejunum and a return of jejunal histologic findings to normal. While he was on this regimen, however, intermittent vertigo and tinnitus and decreased auditory acuity developed. Two days after penicillin was withdrawn, the patient developed acute meningoencephalitis that responded to parenteral penicillin and chloramphenicol therapy. Subsequently, central nervous system signs and symptoms and cerebrospinal fluid pleocytosis have been controlled with chronic chloramphenicol therapy. Penicillin may suppress, but not prevent, central nervous system disease in patients with otherwise successfully treated Whipple's disease.
Anti-ATP synthase autoantibodies alter endothelial cell (EC) survival by disrupting pH regulation in vasculit
Authors: C Jamin, J-E Alard, J-O Pers, P Youinou
Journal: Annals of the Rheumatic Diseases (2010)

B-cell clusters represent genuine germinal centres (GCs) in the SGs of SS patients, but their majority display transitional and marginal zone (MZ)-like B cell characteristics. We thus asked the question as to whether TLR9 stimulation that occurs during inflammatory reaction could influence such an aberrant B-cell differentiation. …
CONTEMPORARY TRENDS OF PHARMACOINVASIVE STRATEGY IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN DIFFERENT REGION OF UNITED STATES: INSIGHTS FROM NATIONWIDE INPATIENT SAMPLE
Authors: Nish Patel, Nileshkumar Patel, Badal Thakkar, Ankit Chothani, Nilay Patel, Shilpkumar Arora, Vikas Singh, Sunny Jhamnani, Sidakpal Panaich, Abhishek Deshmukh, Apurva Badheka, Carlos Alfonso, Mauricio Cohen
Journal: Journal of the American College of Cardiology (2015)
Metastatic Colon Cancer to the Lung With No Detectable Primary Tumor, Mimicking Advanced Primary Lung Cancer on F-18 FDG PET/CT Imaging
Authors: Hae Won Kim, Kyoung Sook Won, Kun Young Kwon, Byung Wook Choi, Seok Kil Zeon
Journal: Clinical Nuclear Medicine (2010)

An 83-year-old man was referred with a right lung mass on dynamic chest computed tomography (CT). F-18 fluoro-deoxy-glucose positron emission tomography (FDG PET)/CT showed intense FDG uptake in the right lung mass and bilateral hypermetabolic mediastinal lymph nodes. CT-guided biopsy of the right lung mass revealed metastatic adenocarcinoma from the colon, but a colon cancer lesion was not detected by dynamic abdominal CT and colonoscopy.
Zinc Gluconate Lozenges for Treating the Common Cold
Authors: James C. Barton
Journal: Annals of Internal Medicine (1997)

Letters1 May 1997Zinc Gluconate Lozenges for Treating the Common ColdJames C. Barton, MD and Luigi F. Bertoli, MDJames C. Barton, MDSouthern Iron Disorders Center, Birmingham, AL 35209Search for more papers by this author and Luigi F. Bertoli, MDSouthern Iron Disorders Center, Birmingham, AL 35209Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-9-199705010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest the paper by Mossad and colleagues [1] on the use of zinc gluconate for treating colds. However, we were concerned by the authors' statement that “individual patients must decide whether the possible beneficial effects of zinc gluconate on cold symptoms outweigh the possible adverse effects.” In the United States, approximately 1 million persons are hemochromatosis homozygotes; in most persons, however, this condition is not diagnosed. An estimated 25 million persons are hemochromatosis heterozygotes. In most homozygotes and some heterozygotes, the gastrointestinal absorption of iron, cobalt, and lead is increased [2]. In homozygotes, the ...References1. Mossad SB, Macknin ML, Medendorp SV, Mason P. Zinc gluconate lozenges for treating the common cold. A randomized, double-blind, placebo-controlled study. Ann Intern Med. 1996; 125:81-8. Google Scholar2. Barton JC, Patton MA, Edwards CQ, Griffen LM, Kushner JP, Meeks RG, et al. Blood lead concentrations in hereditary hemochromatosis. J Lab Clin Med. 1994; 124:193-8. Google Scholar3. Adams PC, Bradley C, Frei JV. Hepatic zinc in hemochromatosis. Clin Invest Med. 1991; 14:16-20. Google Scholar4. Spencer H, Sontag SJ, Derler J, Osis D. Intestinal absorption of iron in patients with hemochromatosis. Ann N Y Acad Sci. 1988; 526:336-8. Google Scholar5. Brissot P, Le Treut A, Dien G, Cottencin M, Simon M, Bourel M. Hypovitaminemia A in idiopathic hemochromatosis and hepatic cirrhosis. Role of retinol-binding protein and zinc. Digestion. 1978; 17:469-78. Google Scholar Author, Article, and Disclosure InformationAffiliations: Southern Iron Disorders Center, Birmingham, AL 35209 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByManagement of HemochromatosisJames C. Barton, MD, Sharon M. McDonnell, MD, MPH, Paul C. Adams, MD, Pierre Brissot, MD, Lawrie W. Powell, MD, Corwin Q. Edwards, MD, James D. Cook, MD, and Kris V. Kowdley, MD, and The Hemochromatosis Management Working Group* 1 May 1997Volume 126, Issue 9Page: 738-739KeywordsAllelesAttentionCirrhosisCommon coldExcretionHemochromatosisLiverSafetySaltsZinc Issue Published: 1 May 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Suffering Made Real: American Science and the Survivors at Hiroshima
Authors: Frank W. Putnam
Journal: JAMA (1995)

The longest and most comprehensive medical genetics study ever undertaken is the still ongoing investigation of the late effects on health of the atomic bombings of Hiroshima and Nagasaki. Inter alia this research has provided the primary basis for regulatory standards for radiation exposure in occupational and medical settings. This binational study was begun in 1946 by the National Academy of Sciences/National Research Council (NAS/ NRC) with the appointment of a committee that became the Atomic Bomb Casualty Commission (ABCC). One member was Lt James V. Neel, MC, AUS, a young geneticist with an MD and PhD. Ever since, he has studied the genetic effects of the atomic bombs, and he is the chief protagonist in this book. Though a cooperative study by the Americans and the Japanese and mainly staffed by the latter, ABCC was administered by NAS/NRC. Funding came from the Atomic Energy Commission (AEC); this, and the
Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle
Authors: Hans D Daetwyler, Aurélien Capitan, Hubert Pausch, Paul Stothard, Rianne van Binsbergen, Rasmus F Brøndum, Xiaoping Liao, Anis Djari, Sabrina C Rodriguez, Cécile Grohs, Diane Esquerré, Olivier Bouchez, Marie-Noëlle Rossignol, Christophe Klopp, Dominique Rocha, Sébastien Fritz, André Eggen, Phil J Bowman, David Coote, Amanda J Chamberlain, Charlotte Anderson, Curt P VanTassell, Ina Hulsegge, Mike E Goddard, Bernt Guldbrandtsen, Mogens S Lund, Roel F Veerkamp, Didier A Boichard, Ruedi Fries, Ben J Hayes
Journal: Nature Genetics (2014)
IMPACTED FRACTURES OF THE NECK OF THE FEMUR.REPORTS OF TWO INTERESTING CASES.
Authors: LE MOYNE WILLS
Journal: JAMA (1904)

During the past year I have treated two cases of impacted fracture of the neck of the femur; one I took charge of within the first twenty-four hours after injury; the second, after four months had gone by. They differed as much in age, manner of production of injury and treatment as in the results obtained. <h3>Case 1.History.</h3> —Mrs. K. C, Sherman, Cal., aged 76, widow, born in Virginia, of large frame and good health, except for rheumatism of knees. June 22, 1903, while walking on a boardwalk in her garden, she slipped and fell heavily on right hip and thigh, producing a severe contusion and pain, and was unable to get up or stand. She was put to bed and a physician summoned from Hollywood. He carefully examined her, and, diagnosing fracture, put on Buck's extension with a 10-pound
Sepsis carries a high mortality among hospitalised adults in Malawi in the era of antiretroviral therapy scale-up: A longitudinal cohort study
Authors: Peter I. Waitt, Mavuto Mukaka, Patrick Goodson, Felanji D. SimuKonda, Catriona J. Waitt, Nick Feasey, Theresa J. Allain, Paul Downie, Robert S. Heyderman
Journal: Journal of Infection (2014)

To assess mortality risk among adults presenting to an African teaching hospital with sepsis and severe sepsis in a setting of high HIV prevalence and widespread ART uptake.
Doctors in Politics: A Lesson from Chile
Authors: Albert R. Jonsen, Alfredo Paredes, Leonard Sagan
Journal: New England Journal of Medicine (1974)

The Journal recently published an article entitled "Medicine, Socialism and Totalitarianism: Lessons from Chile."* Its authors, Howard Waitzkin, M.D., and Hilary Modell, describe the attempt of the Allende government to modify the Chilean health system in socialist directions, the severe persecution of leftist physicians after the coup of September 11, 1973, and the subsequent efforts of the Junta government to redirect the health system back into more conservative paths. We have recently returned from a two-week mission, sponsored by the Federation of American Scientists, to investigate the situation of physicians in Chile. Although we question some statements of fact in . . .
Review of Gregory Pence,<i>How to Build a Better Human: An Ethical Blueprint</i>
Authors: William P. Kabasenche
Journal: The American Journal of Bioethics (2013)

"Review of Gregory Pence, How to Build a Better Human: An Ethical Blueprint ." The American Journal of Bioethics, 13(5), pp. 72–73 Acknowledgments Notes 1Lanham, MD: Rowman & Littlefield Publishers, Inc., 2012. $35.00 hardcover.
Letter: Early detection of growth hormone deficiency.
Authors: P H Sonksen, J V Scopes, T E West, C Lowy, F T Prunty, B D Wilson, G M Jeremiah
Journal: BMJ (1976)

Patients with cystic fibrosis (CF) experience multiple pulmonary exacerbations throughout their lifetime, resulting in repeated antibiotic exposure and hospital admissions. Reliable diagnostic markers to guide antibiotic treatment in patients with CF, however, are lacking. Given that the CF airway is characterized by persistent and frequent bacterial infection, our goal was to determine if procalcitonin (PCT) could be used as a severity and prognostic marker of CF exacerbation. We enrolled 40 participants at the time of diagnosis of CF pulmonary exacerbation. Inclusion criteria: age ≥19 years with exacerbation requiring antibiotics as determined by the treating physician. Exclusion criteria: antibiotics initiated more than 48 hours prior to enrollment, and pregnancy. Blood samples were collected on enrollment day and after 7–10 days of treatment. Of the 40 patients enrolled, 23 (57.5%) had detectable levels of PCT (≥0.05 ng/mL). PCT levels were significantly associated with pulmonary exacerbation scores (p=0.01) and per cent decrease in forced expiratory volume in 1 second (FEV<sub>1</sub>) (p=0.01) compared with the best in the last 12 months. Those who had worsening PCT during treatment had less improvement in FEV<sub>1</sub> (p=0.001) and were more likely to be readmitted to the hospital sooner (p&lt;0.0001). Likewise, those who had a detectable PCT at the time of admission were more likely to be readmitted sooner (p=0.03). PCT elevation during antibiotic treatment is associated with less improvement in FEV<sub>1</sub> and earlier readmission. A detectable PCT level occurs only in more severe CF exacerbations. Multicenter trials are needed to confirm whether PCT may play a role in the clinical care of patients with CF.
SUCCESSFUL TREATMENT OF ACUTE POSTOPERATIVE ILEUS,BY INCISION AND DRAINAGE OF THE INTESTINE, WITH REPORT OF FOUR CASES.
Authors: FRANCIS D. DONOGHUE
Journal: JAMA (1907)

Some paralysis of peristaltic activity usually follows surgical interference in the abdominal cavity. It is more common after operations on acute inflammatory or suppurative conditions, but may follow apparently slight operations with clean conditions of the peritoneum. The milder forms are readily overcome by some of the usual postoperative procedures. Those cases which do not yield to ordinary treatment, however, and especially those cases accompanying localized or general peritonitis, present a most dangerous and trying complication. Whatever may be the actual causative factors in the production of acute postoperative ileus, the practical results are of a mechanical nature, plus poisoning from the products of intestinal decomposition. This peristaltic inertia is often aggravated by adhesions between loops of intestines causing "kinking," or from slight adhesions between the omentum and some viscus or inflamed surface. These adhesions, not in themselves of a character and extent to cause trouble, may become of serious
Fracture of the Laryngeal Cartilage An Incidental Finding on Bone Scintigraphy
Authors: ROBERT D. STEUART, R T MORRISON
Journal: Clinical Nuclear Medicine (1992)

A patient complaining of headaches and bone pain at multiple sites had Tc-99m MDP scintigraphy performed for possible bone trauma after a motor vehicle accident. Bone imaging revealed a small focal increase in tracer uptake in the area of the laryngeal cartilage. There was some reluctance to place a label on this abnormality because the findings were so unusual. The initial diagnosis was a probable fracture of the laryngeal cartilage. Computed tomography of the neck also demonstrated a fracture but correctly localized it to the thyroid cartilage.
The arthritis sufferer and the community: a comparison of arthritis sufferers in rural and urban areas.
Authors: P G Cornelissen, J J Rasker, H A Valkenburg
Journal: Annals of the Rheumatic Diseases (1988)

One hundred and two rural patients and 100 urban patients with rheumatoid arthritis and osteoarthrosis and 203 age and sex matched controls were visited in their homes to evaluate their problems, needs, and expectations. Although one would expect disability to affect the mobility of a person, it was found that rural patients were more mobile than their urban counterparts despite the same degree of functional disability. They were more content with their lot, even though their circumstances were less favourable. Both groups of patients had little contact with their general practitioners, social workers, or district nurses, and lacked information about their disease and the availability of financial grants or home adaptations. The main problem for the individual patient was not pain, but the frustration of being unable to do things they used to do and of dependency on others.
Treatment of Unexpected Cardiac Arrest by External Electric Stimulation of the Heart
Authors: Paul M. Zoll, Arthur J. Linenthal, Leona R. Norman, Milton H. Paul, William Gibson
Journal: New England Journal of Medicine (1956)

CARDIAC arrest may occur unexpectedly during various diagnostic and therapeutic procedures, particularly under anesthesia. Though infrequent (1 in every 500 to 5000 operations1 , 2), each accident is a catastrophe. Despite the wide, active interest in this problem current therapy is too often unsuccessful.The commonly recognized mechanisms of cardiac arrest are ventricular standstill and ventricular fibrillation; standstill is the usual cause. In a compilation of 1200 cases of cardiac arrest, Stephenson et al.3 placed the occurrence of standstill at 88 per cent. Of 141 cases4 5 6 7 8 in which the mechanisms were specifically diagnosed by electrocardiograms or direct observations of the heart, . . .
Chemical Rhizotomy for Relief of Spasticity in Ambulant Patients
Authors: P. W. Nathan
Journal: BMJ (1965)

In a previous paper (Nathan, 1959) it was stated that when patients who were apparently completely paralysed by upper motor neurone lesions causing spasticity were treated with con centrated solutions of phenol applied around the spinal roots voluntary movements were sometimes uncovered, and it was stated that this technique was being modified so that it might be used for the treatment of spastic patients who can still walk. Since then considerable experience has been gained with modifications of this technique and from experimental studies on cats. The results of this modified treatment are reported here. Films taken before and after treatment are the best way of showing the results, and they were made in all cases ; but as they reach only a small number of those who treat these patients it is also essential to report the results in a paper. Although the series of cases is small, the results obtained show that this kind of chemical rhizotomy is of definite value in the treatment of ambulant spastic patients. Twenty-four patients in whom the aim was to improve their walking were treated ; in addition the upper limb was also treated in two patients with hemiplegia.
Catastrophic antiphospholipid antibody Syndrome
Authors: Stephan Moll, Fred J. Kudrik, David B. Thomas
Journal: American Journal of Hematology (2003)

A 35-year-old woman, who presented with a 3-day history of confusion, was found to have a serum creatinine of 10.7 mg/dL.Renal failure appeared to be acute in onset, as 10 days earlier she had undergone an elective resection of a meningioma, and her serum creatinine had
THE RELATION OF SPECIFIC GRAVITY TO GLYCOSURIA IN DIABETIC AND NONDIABETIC CASES
Authors: HENRY J. JOHN
Journal: JAMA (1923)

This study was suggested by the realization that too frequently in a case of suspected diabetes the general practitioner gives a negative opinion based solely on the fact that a rapid routine examination of the urine has shown a specific gravity below 1.030. Taking it for granted that if the urine contains sugar the specific gravity must be above that figure, he does not consider it necessary to make a urinary sugar test. Laboratory experience has shown, however, that sugar can be present in urine of a low specific gravity; but whether this was a rare or a frequent occurrence I did not know, and for that reason the investigation reported here was undertaken. In 1,000 cases of glycosuria, the specific gravity was compared with the urine sugar content, the cases being classified according to the specific gravity (Table 1). Chart 1 shows that as one would expect, the percentage
Research body helps to boost the number of patients in clinical trials
Authors: Susan Mayor
Journal: BMJ (2008)

A shake-up in the way research is organised in the NHS has led to a massive increase in the numbers of patients taking part in clinical trials, according to a report published this week.

The National Institute for Health Research, set up in 2006 to oversee NHS research in England, says that setting up research networks has been central to achieving its first goal—to establish the NHS as an internationally recognised centre of research excellence. The networks are providing the framework needed to support clinical trials across the country, the report says. 

The new networks include a primary care research network, six topic specific clinical research networks—for cancer, dementias …
Personal PM2.5 Exposure and Markers of Oxidative Stress in Blood
Authors: Mette Sørensen, Bahram Daneshvar, Max Hansen, Lars O. Dragsted, Ole Hertel, Lisbeth Knudsen, Steffen Loft
Journal: Environmental Health Perspectives (2002)

Ambient particulate air pollution assessed as outdoor concentrations of particulate matter less than or equal to 2.5 micro m in diameter (PM(2.5)) in urban background has been associated with cardiovascular diseases at the population level. However, the significance of individual exposure and the involved mechanisms remain uncertain. We measured personal PM(2.5) and carbon black exposure in 50 students four times in 1 year and analyzed blood samples for markers of protein and lipid oxidation, for red blood cell (RBC) and platelet counts, and for concentrations of hemoglobin and fibrinogen. We analyzed protein oxidation in terms of gamma-glutamyl semialdehyde in hemoglobin (HBGGS) and 2-aminoadipic semialdehyde in hemoglobin (HBAAS) and plasma proteins (PLAAS), and lipid peroxidation was measured as malondialdehyde (MDA) in plasma. Median exposures were 16.1 micro g/m(3) for personal PM(2.5) exposure, 9.2 micro g/m(3) for background PM(2.5) concentration, and 8.1 X 10(-6)/m for personal carbon black exposure. Personal carbon black exposure and PLAAS concentration were positively associated (p < 0.01), whereas an association between personal PM(2.5) exposure and PLAAS was only of borderline significance (p = 0.061). A 3.7% increase in MDA concentrations per 10 micro g/m(3) increase in personal PM(2.5) exposure was found for women (p < 0.05), whereas there was no significant relationship for the men. Similarly, positive associations between personal PM(2.5)exposure and both RBC and hemoglobin concentrations were found only in women (p < 0.01). There were no significant relationships between background PM(2.5) concentration and any of the biomarkers. This suggests that exposure to particles in moderate concentrations can induce oxidative stress and increase RBCs in peripheral blood. Personal exposure appears more closely related to these biomarkers potentially related to cardiovascular disease than is ambient PM(2.5) background concentrations.
A comparison of triamcinolone acetonide nasal aerosol spray and fluticasone propionate aqueous solution spray in the treatment of spring allergic rhinitis
Authors: Peter Small, Pierre-Alain Houle, James H. Day, Maureen Briscoe, Milton Gold, Ivan Brodarec, Anthony Ham Pong, Michael Mandl, Jean Spénard, Robert Phillips, Monique Furlan
Journal: Journal of Allergy and Clinical Immunology (1997)
Review of pharmacodynamics, pharmacokinetics, and therapeutic properites of sulodexide
Authors: J. Harenberg
Journal: Medicinal Research Reviews (1998)

Due to various side effects of heparin, such as heparin-induced thrombocytopenia type I or type II, alternative anticoagulants are in clinical development to optimize the anticoagulant regimes in patients requiring low or high anticoagulation dosages. Sulodexide is a highly purified preparation containing a fast-moving heparin fraction as well as dermatansulfate. The pharmacological effects of sulodexide differ substantially from unfractionated heparin and are mainly characterized by a prolonged half-life and reduced effect on global coagulation and bleeding parameters. The lipolytic activity of sulodexide is increased in comparison to unfractionated heparin. Clinical studies demonstrate the safety and efficacy of sulodexide. Specially, oral administration leads to fibrinolytic activities in contrast to oral administration of other glycosaminoglycans. Thus, sulodexide releases tissue plasminogen activator and decreases fibrinogen levels as well as HDL and total cholesterol levels and blood viscosity. Clinical efficacy is demonstrated in peripheral arterial disease, cardiovascular events, in postphlebitic syndrome and on albuminuria in nephropathy. © 1998 John Wiley & Sons, Inc. Med Res. Rev. 18, No. 1, 1-20, 1998.