An Abnormal Pre-Beta Lipoprotein in Patients with Systemic Mastocytosis
Authors: MARIANNE FRIERI
Journal: Annals of Internal Medicine (1982)

Brief Reports1 August 1982An Abnormal Pre-Beta Lipoprotein in Patients with Systemic MastocytosisMARIANNE FRIERI, Ph.D., M.D., NICHOLAS M. PAPADOPOULOS, Ph.D., MICHAEL A. KALINER, M.D., DEAN D. METCALFE, M.D.MARIANNE FRIERI, Ph.D., M.D.Search for more papers by this author, NICHOLAS M. PAPADOPOULOS, Ph.D.Search for more papers by this author, MICHAEL A. KALINER, M.D.Search for more papers by this author, DEAN D. METCALFE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-2-220 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSystemic mastocytosis is a multisystem disease involving mast cell proliferation in the skin, bone, lymph nodes, liver, spleen, and gastrointestinal tract. When mast cell proliferation is limited to the skin, the disease is more benign and is termed urticaria pigmentosa. Patients with systemic mastocytosis experience numerous problems attributable to an excess of mast-cell-derived chemical mediators. These difficulties include pruritis, flushing, hypotension, and peptic ulcer disease among others (1). It has been suggested that one of the functions of mast cells may be the prevention of atherosclerosis due to the lipid-clearing actions of mast cell heparin (2). However, patients with systemic...References1. PARKER F and ODLAND G. The mastocytosis syndrome. In: FITZPATRICK TB, EISEN AZ, WOLF K, FREILBERG IM, AUSTEN KF, eds. Dermatology in General Medicine. New York: McGraw-Hill Book Co. ; 1979;772-83. Google Scholar2. OLIVECRONA T, BENGTSSON G, MARKLUND S, LINDAHL U, and HOOK M. Heparin-lipoprotein lipase interactions. Fed Proc. 1977;36:60-5. MedlineGoogle Scholar3. MUTTER R, TANNENBAUM M, and ULTMANN J. Systemic mast cell disease. Ann Intern Med. 1963;59:887-906. LinkGoogle Scholar4. MYERS G, DONLON M, and KALINER M. Measurement of urinary histamine: development of methodology and normal values. J Allergy Clin Immunol. 1981;67:305-11. CrossrefMedlineGoogle Scholar5. LEON L and STASIW R. Performance of automated enzymatic cholesterol on SMA 12/60 and autoanalyzer II instruments [Abstract]. Clin Chem. 1976;22:1220a. Google Scholar6. ELLEFSON R and CARAWAY W. Lipids and lipoproteins. In: TIETZ N, ed. Fundamentals of Clinical Chemistry. Philadelphia: W. B. Saunders Co.; 1976;474-538. Google Scholar7. PAPADOPOULOS N, BORER W, ELIN R, and DIAMOND L. An abnormal lipoprotein in the serum of uremic patients maintained on chronic hemodialysis. Ann Intern Med. 1980;92:634-8. LinkGoogle Scholar8. PAPADOPOULOS N and BEDYNEK J. Serum lipoprotein patterns in patients with coronary atherosclerosis. Clin Chim Acta. 1973;44:153-7. CrossrefMedlineGoogle Scholar9. METCALFE D, DONLON M, and KALINER M. The mast cell. Crit Rev Immunol. 1981;3:23-74. MedlineGoogle Scholar10. HOFF H, LIE J, and TITUS J. Lipoproteins in atherosclerotic lesions: localization by immunofluorescence of apo-low density lipoproteins in human atherosclerotic arteries from normal and hyperlipoproteinemias. Arch Pathol. 1975;99:253-8. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARIANNE FRIERI, Ph.D., M.D.; NICHOLAS M. PAPADOPOULOS, Ph.D.; MICHAEL A. KALINER, M.D.; DEAN D. METCALFE, M.D.Affiliations: National Institutes of Health Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMastocytosisNeuroimmunology and inflammation: implications for therapy of allergic and autoimmune diseasesAcute nonlymphocytic leukemia in systemic mastocytosis with biclonal gammopathyInsuffisance cardiaque droite révélatrice d'une mastocytose systémiqueSystemic Mastocytosis: Retrospective Review of a Decade's Clinical Experience at the Brigham and Women's HospitalLymphadenopathic mastocytosis with eosinophilia and biclonal gammopathyLocal and Systemic Factors in the Pathogenesis of OsteoporosisMast cell: Its mediators and effects on arterial wall metabolism 1 August 1982Volume 97, Issue 2 Page: 220-221 Keywords Cell proliferation Lymph nodes Mast cells Mastocytosis Peptic ulcers Pruritus Skin diseases Spleen Systemic mastocytosis Urticaria ePublished: 1 December 2008 Issue Published: 1 August 1982 PDF downloadLoading ...