tbuckley/cabot-search huggingface dataset:
The Syndrome of Patent Ductus Arteriosus with Pulmonary Hypertension
Authors: HERBERT HULTGREN, ARTHUR SELZER, ANN PURDY, EMILE HOLMAN, FRANK GERBODE
Journal: Circulation (1953)

Eight cases of patent ductus arteriosus associated with marked pulmonary hypertension are presented with complete cardiac catheterization studies in six patients and autopsy studies in three cases. Four patients had clear evidence of a "reversed" shunt through the ductus, three presenting the clinical picture of cyanotic congenital heart disease. The authors discuss the nature of the increased resistance of the pulmonary vascular bed which is the basis of the circulatory changes in these cases.
Cholera on the Texas Gulf Coast
Authors: Michael T. Kelly, Johnny W. Peterson, Harry E. Sarles, Michael Romanko, Deborah Martin, Barry Hafkin
Journal: JAMA (1982)

Cholera is being increasingly recognized in the Gulf Coast region. This report describes two cholera cases of classic clinical presentation. Both cases were caused by toxigenic Vibrio cholerae, one of an 01 serotype and one of a non-01 serotype. Vibrio cholerae was also isolated from the home environments of both patients. These findings indicate that cholera continues to be detected on the Gulf Coast, that non-01 V cholerae infections may be clinically indistinguishable from V cholerae 01 infections, and that both 01 and non-01 V cholerae strains are capable of survival in Gulf Coast environments.
V̇o<sub>2</sub>slow component and performance in endurance sports
Authors: Véronique L Billat
Journal: British Journal of Sports Medicine (2000)

Pneumomediastinum is not a rare complication of antimelanoma differentiation-associated gene 5 (anti-MDA5)–positive dermatomyositis (DM)-associated interstitial lung disease (ILD). Here, we reported a rare case of subcutaneous facial and posterior pharyngeal emphysema due to pneumomediastinum in anti-MDA5-positive DM.
Hepatic injury caused by mianserin.
Authors: K. Otani, S. Kaneko, H. Tasaki, Y. Fukushima
Journal: BMJ (1989)

since transurethral resection two weeks before.Is this appreciable reduction in morbidity?Certainly he did not have to stay long in hospital, but who is to say that the current operative technique is more agreeable than open prostatectomy-it is done by the same surgeons, registrars, and house officers with intact prostates, who assert that retrograde ejaculation elicits the same sensation as normal.And did one of them consider asking me whether I wanted another child before thev rendered mv husband infertile?Nomy consent was never sought.He was on the
Corticosteroid irrigation of parotid gland for treatment of xerostomia in patients with Sjogren's syndrome
Authors: M. Izumi, K. Eguchi, H. Nakamura, Y. Takagi, Y. Kawabe, T. Nakamura
Journal: Annals of the Rheumatic Diseases (1998)

To determine the efficacy of corticosteroid irrigation of the parotid gland in relieving salivary flow deficiency in patients with Sjögren's syndrome.The parotid glands of 31 patients with primary (24) or secondary (seven) Sjögren's syndrome were irrigated either with saline solution followed by corticosteroid solution, or with saline solution alone. Salivary function was assessed by Saxon test.Corticosteroid irrigation significantly increased the salivary flow rate in patients with Sjögren's syndrome (p < 0.0001), with clinical improvement detectable 3.7 (2.4) weeks (mean (SD)) after initial corticosteroid irrigation. The extent of improvement in salivary function was reciprocal to the clinical severity of the disease, with patients at the early stages obtaining 1.20 (0.57) g net increase in salivary flow rate, and patients at the most advanced stages obtaining 0.20 (0.47) g net increase. Repeated corticosteroid irrigations did not evoke corticosteroid refractoriness of the salivary gland; similar levels of net increase in salivary flow rate were observed after the second to fourth challenge of the corticosteroid in these patients. The sustained period was 8.4 (3.5) months (mean (SD)).These findings suggest the clinical usefulness of corticosteroid irrigation therapy in relieving xerostomia in patients with Sjögren's syndrome.
Endothelium dependent vasomotor responses to endogenous agonists are potentiated following ACE inhibition by a bradykinin dependent mechanism
Authors: J. Zanzinger, X. Zheng, E. Bassenge
Journal: Cardiovascular Research (1994)

Objective: The aim was to investigate the effects of angiotensin converting enzyme inhibition on agonist induced endothelium dependent vasodilatation in vivo. Methods: Chronically instrumented conscious dogs (n = 8) were prepared for the measurement of coronary blood flow, diameter of the left circumflex coronary artery, mean arterial blood pressure, and heart rate. Intracoronary infusions of acetylcholine, adenosine, and bradykinin that induced dose dependent increases in coronary blood flow and diameter were performed with and without intracoronary administration of captopril (1 mg·kg−1) and enalapril (0.4 mg·kg−1)- The effects were studied of concomitant inhibition of bradykinin actions by the specific B2 kinin antagonist HOE-140 (10−7 M), NO-synthesis by NG-nitro-L-arginine-methyl ester (L-NAME, 2 X 10−5 M), or cyclo-oxygenase by indomethacin (10−7 M) (all intracoronary). Results: Neither captopril nor enalapril had significant vasodilating effect on the coronary vasculature when given alone. In contrast, both ACE inhibitors potentiated the agonist induced increases in coronary blood flow by bradykinin and acetylcholine (p ≤ 0.01). HOE-140 strongly antagonised the effects of infused bradykinin and prevented the potentiation of acetylcholine responses by ACE inhibition. L-NAME caused hypertension and bradycardia and abolished the responses to acetylcholine and adenosine, but only partially attenuated the bradykinin induced increases in coronary blood flow. Simultaneous ACE inhibition reduced the hypertensive effect of L-NAME and partially restored the responses to bradykinin. Indomethacin reduced the responses to bradykinin but did not affect acetylcholine and adenosine induced coronary vasodilatation. The potentiation of the response to acetylcholine induced by ACE inhibition was, however, diminished by indomethacin. Conclusions: In the coronary vasculature of the dog, ACE inhibitors enhance vasomotor responses to endothelium dependent agonists by facilitating the release of both NO and PGI2, a mechanism which is coupled to endogenously formed bradykinin. ACE inhibitors may thus mediate their effects in vivo partly by increasing the capacity of the endothelium to release autacoids. Cardiovascular Research 1994;28:209-214
ADRENAL ATROPHY AND IRREVERSIBLE SHOCK ASSOCIATED WITH CORTISONE THERAPY
Authors: Charles G. Fraser
Journal: JAMA (1952)

Recent clinical observations and animal experiments<sup>1</sup>have shown that prolonged administration of cortisone produces adrenal atrophy. According to the adaptation syndrome of Selye,<sup>2</sup>adrenal atrophy in turn may lessen the body's ability to withstand trauma and stress. One might suspect that patients receiving cortisone would not normally withstand major surgery; yet every day patients are successfully undergoing surgery while regularly taking cortisone in both the preoperative and postoperative periods. We wish to present the record of a patient who, while receiving a prolonged course of cortisone therapy, underwent a major operation, cup arthroplasty of the hip, and died of immediate postoperative shock, in spite of normally adequate, aggressive antishock therapy. Postmortem examination revealed marked bilateral adrenal atrophy and other conditions consistent with shock. <h3>REPORT OF A CASE</h3> A 34-year-old man had had rheumatoid arthritis for a period of seven years. Almost every joint of his body was involved,
307 THE NON-SPECIFIC ACTIVATION OF LIVER CELLS BY THERAPEUTICALLY APPLICATED SIRNAS IS MINIMIZED BY CHEMICAL RIBOSE MODIFICATIONS OF THE SIRNA BACKBONE
Authors: C.I. Real, R. Broering, K. Jahn-Hofmann, L. Ickenstein, M. John, K. Kleinehr, J.F. Schlaak, G. Gerken
Journal: Journal of Hepatology (2011)
Relative Importance of Parathyroid Hormone and Thyrocalcitonin in Calcium Homeostasis
Authors: Louis M. Sherwood
Journal: New England Journal of Medicine (1968)

ALTHOUGH it has long been recognized that the serum calcium is maintained within rigid physiologic limits, it is only in the past decade that the hormonal factors involved in this regulation have been defined in biochemical terms and that detailed investigation of their mode of action has been initiated. Developments during this period have included the following: purification of bovine parathyroid hormone (PTH) and partial characterization of the molecular features essential for its biologic activity1; examination of a variety of in vivo and in vitro models to define the mechanism of action of the hormone2; direct measurement of . . .
Dehydroepiandrosterone sulfate, incidence of myocardial infarction, and extent of atherosclerosis in men.
Authors: A Z LaCroix, K Yano, D M Reed
Journal: Circulation (1992)

BACKGROUND Antiatherogenic effects of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) have been suspected for more than 30 years, yet the available evidence to support or refute such effects in humans is inconclusive. The hypothesis has not been adequately tested in large-scale epidemiological studies. METHODS AND RESULTS The present study used a cohort of men initially free of clinically detectable coronary heart disease, stroke, and cancer to compare DHEAS levels measured in sera obtained in 1968-1971 between 238 cases who had definite coronary heart disease during the subsequent 18 years and 476 age-matched controls who survived the follow-up period and remained free of clinically detectable coronary heart disease. In a separate study, the relation of DHEAS levels to extent of atherosclerosis was examined among 82 cohort men who died during the follow-up period and had protocol autopsies. Age-adjusted DHEAS levels were lower among fatal cases of coronary heart disease than among controls (94.7 versus 106.9 micrograms/dl, respectively; p &lt; 0.05). After adjustment for eight coronary risk factors, the odds ratio for fatal coronary heart disease comparing a 100-micrograms/dl difference in DHEAS level was 0.46 (95% confidence intervals, 0.19-1.07). In contrast, age-adjusted DHEAS levels did not significantly differ between nonfatal cases of myocardial infarction and controls (107.2 versus 106.9 micrograms/dl, respectively). Furthermore, DHEAS levels were not related to extent of atherosclerosis at autopsy. CONCLUSIONS These findings do not support a role of DHEAS in the development of nonfatal myocardial infarction or the progression of atherosclerosis. The association of DHEAS with fatal coronary heart disease and possibly with death from all causes merits further investigation. These findings suggest continued skepticism that DHEAS has an important role in coronary disease etiology or prevention.
Cutaneous Localization of Ga-67 in Systemic Sarcoidosis
Authors: PRASHANT K. ROHATGI
Journal: Clinical Nuclear Medicine (1981)

Ga-67 scans have been used in patients with sarcoidosis to assess noninvasively the intensity of alveolitis and to detect areas of extrathoracic involvement. To the author's knowledge, this is the first report of the localization of gallium in cutaneous lesions of a patient with sarcoidosis.
Fidelity of Pathogen-Specific CD4+ T Cells to the Th1 Lineage Is Controlled by Exogenous Cytokines, Interferon-γ Expression, and Pathogen Lifestyle
Authors: Meredith M. Curtis, Emily Rowell, Shahin Shafiani, Amina Negash, Kevin B. Urdahl, Christopher B. Wilson, Sing Sing Way
Journal: Cell Host & Microbe (2010)
A comparative study of the cytotoxicity of skin irritants on cultured human oral and skin keratinocytes
Authors: H.C. EUN, J.H. CHUNG, S.Y. JUNG, K.H. CHO, K.H. KIM
Journal: British Journal of Dermatology (1994)

Journal Article A comparative study of the cytotoxicity of skin irritants on cultured human oral and skin keratinocytes Get access H.C. EUN, H.C. EUN Department of Dermatology, Seoul National University, College of Medicine, Seoul, Korea Dr H.C. Eun, Department of Dermatology, Seoul National University Hospital, 28 Chongno Ku, Yunkundong, Seoul, 110–744. Korea. Search for other works by this author on: Oxford Academic Google Scholar J.H. CHUNG, J.H. CHUNG Department of Dermatology, Seoul National University, College of Medicine, Seoul, Korea Search for other works by this author on: Oxford Academic Google Scholar S.Y. JUNG, S.Y. JUNG Department of Dermatology, Seoul National University, College of Medicine, Seoul, Korea Search for other works by this author on: Oxford Academic Google Scholar K.H. CHO, K.H. CHO Department of Dermatology, Seoul National University, College of Medicine, Seoul, Korea Search for other works by this author on: Oxford Academic Google Scholar K.H. KIM K.H. KIM Department of Otolaryngology, Seoul National University, College of Medicine, Seoul, Korea Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 130, Issue 1, 1 January 1994, Pages 24–28, https://doi.org/10.1111/j.1365-2133.1994.tb06877.x Published: 01 January 1994 Article history Accepted: 10 June 1993 Published: 01 January 1994
Defining Research to Improve Health Systems
Authors: Jan H. F. Remme, Taghreed Adam, Francisco Becerra-Posada, Catherine D'Arcangues, Michael Devlin, Charles Gardner, Abdul Ghaffar, Joachim Hombach, Jane F. K. Kengeya, Anthony Mbewu, Michael T. Mbizvo, Zafar Mirza, Tikki Pang, Robert G. Ridley, Fabio Zicker, Robert F. Terry
Journal: PLoS Medicine (2010)

Robert Terry and colleagues present working definitions of operational research, implementation research, and health systems research within the context of research to strengthen health systems.
Comparison of Plasma Glucose and Insulin Responses to Mixed Meals of High-, Intermediate-, and Low-Glycemic Potential
Authors: Clarie B Hollenbeck, Ann M Coulston, Gerald M Reaven
Journal: Diabetes Care (1988)

Although plasma glucose and insulin responses have been shown to vary considerably when either normal subjects or patients with non-insulin-dependent diabetes mellitus (NIDDM) consume different carbohydrate-rich foods, it has been difficult to demonstrate this phenomenon when the same foods have been incorporated into a single mixed meal. To pursue this issue further, plasma glucose and insulin concentrations were determined at hourly intervals from 0800 to 2100 h in NIDDM patients in response to three meals (breakfast, lunch, and dinner) calculated to be of low-, intermediate-, and high-glycemic potency. The total integrated glucose response (mean ± SE) during the day the low-glycemic meals were ingested was ∼7% lower (2500 ± 246 mg · dl−1 · h−1) than on the days patients ate either the intermediate- (2701 ± 280 mg · dl−1 · h−1) or high- (2718 ± 311 mg · dl−1 · h−1) glycemic meals. When these data were analyzed by meal, it became apparent that the plasma glucose response to breakfast and dinner were essentially identical after consumption of the meals of either low-, intermediate-, or high-glycemic potency. Thus, the modest attenuation of the day-long glycemic response on the day patients ate the lowglycemic meal was due to a reduction in plasma glucose concentration after lunch. The day-long plasma insulin responses to the meals of different glycemic potency were qualitatively similar.
Abstract 1037: Lysophosphatidic acid upregulates Bcl-2 production and secretion in ovarian cancer cells
Authors: Nicole S. Anderson, Mumtaz Rojiani, Patricia A. Kruk
Journal: Cancer Research (2010)

Abstract Lysophosphatidic acid (LPA) is elevated in the plasma and ascites fluid of ovarian cancer (OC) patients and has been proposed as a diagnostic tool for OC. LPA is the simplest glycerophospholipid and has been shown to have an extensive range of biological activities. LPA is involved in wound healing and tissue regeneration, cell proliferation and survival, platelet aggregation, and tumor cell invasion. In addition, LPA elicits anti-apoptotic activity through upregulation of Bcl-2 in other systems. Bcl-2, the prototypical anti-apoptotic protein, is commonly overexpressed in OC. The purpose of this study was to determine whether LPA regulates Bcl-2 in OC. Using an in vitro cell culture model system, OC cells were treated ± LPA. We found that LPA increased Bcl-2 expression at the protein and message levels using western immunoblotting, ELISA and luciferase reporter assays. Interestingly, LPA also promoted Bcl-2 secretion by OC cells, which is a novel action of Bcl-2. Secreted Bcl-2 appears to modulate angiogenesis by affecting endothelial cell migration as well as tube formation in an in vitro angiogenesis assay using HUVECs. Given that both LPA and Bcl-2 are potential targets in ovarian cancer intervention, elucidating their inter- and regulatory relationships may be of clinical importance and warrants further investigation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1037.
ATP-Gated Ionotropic P2X7 Receptor Controls Follicular T Helper Cell Numbers in Peyer’s Patches to Promote Host-Microbiota Mutualism
Authors: Michele Proietti, Vanessa Cornacchione, Tanja Rezzonico Jost, Andrea Romagnani, Caterina Elisa Faliti, Lisa Perruzza, Rosita Rigoni, Enrico Radaelli, Flavio Caprioli, Silvia Preziuso, Barbara Brannetti, Marcus Thelen, Kathy D. McCoy, Emma Slack, Elisabetta Traggiai, Fabio Grassi
Journal: Immunity (2014)
Umbilical Metastasis From Breast Cancer Detected by FDG PET
Authors: Mathieu Basely, Philippe Bernard, Olivier Gisserot, Philippe Maszelin, Emmanuel Bussy, Jean-Pierre de Jaureguiberry
Journal: Clinical Nuclear Medicine (2009)

A 79-year-old woman with invasive lobular breast carcinoma (staged T2N1M0) was treated by surgery, chemotherapy, radiotherapy and hormonotherapy 11 years earlier. She was referred to our department for a fluorodeoxyglucose (FDG) positron emission tomography (PET), because her serum calcium level recently increased. The whole-body images revealed only a single site of pathologic FDG uptake located in the umbilicus, on the course of the urachal canal. Surgical biopsy of the nodule demonstrated histologic changes consistent with primary breast tumor and confirmed subcutaneous umbilical metastasis, also called “Sister Mary Joseph's nodule.”
School based programmes may help children to report sexual abuse, Cochrane review concludes
Authors: J. Wise
Journal: BMJ (2015)

Children who are taught at school about preventing sexual abuse are more likely than others to report it, a Cochrane review has concluded, but it added that more research is needed to evaluate whether school based prevention programmes actually reduce the incidence of sexual abuse.

At least 1 in 10 girls and 1 in 20 boys experience some form of sexual abuse in childhood, it is estimated. School based programmes for preventing child sexual …
Regional electrophysiological effects of left ventricular hypertrophy in isolated rabbit hearts under normal and ischaemic conditions
Authors: R Wolk
Journal: Cardiovascular Research (2000)

Objectives: Left ventricular hypertrophy (LVH) has been reported to produce differential electrophysiological effects in isolated epicardial and endocardial cells. This study aimed to examine regional electrophysiological effects of LVH in normal and ischaemic conditions in the whole heart. Methods: LVH was secondary to perinephritis-induced hypertension. Monophasic action potential duration (MAPD90), effective refractory period (ERP) and conduction delay were measured in paced, isolated working rabbit hearts either at one right ventricular and two left ventricular sites (apical and basal epicardium) or at three left ventricular sites (apical and basal epicardium, apical endocardium). The hearts were subjected to 30 min of regional ischaemia and 15 min of reperfusion. Results: In non-ischaemic conditions, LVH produced uniform prolongation of MAPD90 and ERP in the left ventricular epicardium, but not in the endocardium. After coronary artery occlusion, LVH significantly increased ischaemia-induced transepicardial dispersion of repolarisation, but not refractoriness. LVH did not affect arrhythmogenesis in either non-ischaemic or ischaemic conditions. Conclusions: Differential effects of LVH on epicardial and endocardial electrophysiological parameters are also observed in the whole heart. In addition, the sensitivity of hypertrophied myocardium to ischaemia is increased and leads to an increase in ischaemia-induced dispersion of repolarisation. However, neither dispersion of refractoriness nor arrhythmogenesis are affected by LVH in non-ischaemic or ischaemic conditions in this experimental model.
The application of biofilm science to the study and control of chronic bacterial infections
Authors: William Costerton, Richard Veeh, Mark Shirtliff, Mark Pasmore, Christopher Post, Garth Ehrlich
Journal: Journal of Clinical Investigation (2003)

Unequivocal direct observations have established that the bacteria that cause device-related and other chronic infections grow in matrix-enclosed biofilms. The diagnostic and therapeutic strategies that have served us so well in the partial eradication of acute epidemic bacterial diseases have not yielded accurate data or favorable outcomes when applied to these biofilm diseases. We discuss the potential benefits of the application of the new methods and concepts developed by biofilm science and engineering to the clinical management of infectious diseases.
Characterization of monoclonal antibodies against human apolipoprotein E.
Authors: R W Milne, P Douste-Blazy, Y L Marcel, L Retegui
Journal: Journal of Clinical Investigation (1981)

From a single cell fusion, five stable hybridomas secreting antiapolipoprotein E (apo E) were obtained. The immunoglobulin (Ig)G subclasses containing the respective monoclonal antibodies were isolated and were used as the antibody component in a solid-phase radioimmunoassay. The binding of 125I-apo E to the insolubilized antibody was inhibited by unlabeled apo E but not by unlabeled apoproteins A-I, A-II, C-II, and C-III, or by low density lipoprotein immunodepleted of endogenous apo E. Competition curves were obtained with lipoprotein subfractions that had the same shape as those obtained with purified apo E. Apo E levels in normal and hyperlipidemic plasma were well correlated when measured by the five monoclonal antibodies and polyclonal anti-apo E, although differences in absolute values were observed. In normal subjects 34, 10, 20, and 36% of apo E was recovered in the very low density lipoprotein, low density lipoprotein, high density lipoprotein, and the d greater than 1.21-gl/ml fractions, respectively, whereas these values were 34, 7, 12, and 47%, respectively, in type III patients. All antibodies indicated the same subfraction distribution of apo E. The monoclonal antibodies reacted with all of the isomorphs of apo E. One of the antibodies could be clearly distinguished by its reactivity with chemically modified very low density lipoprotein.