tbuckley/cabot-search huggingface dataset:
Abstract 5006: Interleukin-1 receptor type II regulates matrix metalloproteinases expression and plays oncogenic roles in HaCaT cells
Authors: Hui-Ju Lee, Ai-Chung Mar, Te-Chang Lee
Journal: Cancer Research (2011)

Abstract Interleukin-1 receptor type II (IL1R2) is an IL-1 decoy receptor, which plays a role to inhibit exogenous IL-1 signaling. Intriguingly, IL1R2 also performs as a pro- inflammatory factor via activation of intracellular IL-1α signaling in a variety of cells. In our previous study, we reported that long term arsenic exposure resulted in increased IL1R2 expression which led to increased motility of human urothelial cells. In the present study, we similarly found that the expression of IL1R2 was increased in long-term arsenic exposed HaCaT cells (A1, A2) and the tumorigenic derivative, T4R2 cells. Since matrix metalloproteinases (MMPs) are frequently increased in a variety of malignant tissues including skin cancer, we also revealed that a positive association of IL1R2 and MMP1 and MMP7 at either mRNA or protein levels, which were analyzed by quantitative real time RT-PCR and western blotting, respectively. To reveal the involvement of IL1R2 in up-regulation of MMPs, we adopted shRNA technique to silence the expression of IL1R2 in T4R2 cells. Our results demonstrated that MMP1 and MMP7 were suppressed in IL1R2 silencing T4R2 cells. Meanwhile, we found the enhanced expression of MMP1 and MMP7 in HaCaT cells with ectopically expressed IL1R2. Furthermore, we confirmed our previous finding showing that IL1R2 overexpression was accompanied with increased expression of precursor form of IL-1α protein (preIL-1α). Immunofluorescence staining showed the colocalization of IL1R2 and preIL-1α in the nucleus. In a xenograft mouse model, we found that HaCaT cells with ectopical expression of IL1R2 formed tumor in nude mice whereas IL1R2 silencing in T4R2 cells suppressed the tumorigenicity. Taken together, these results implicate that IL1R2 plays an oncogenic role in human keratinocyte transformation by upregulation of MMPs expression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5006. doi:10.1158/1538-7445.AM2011-5006
Endoscopic Diagnosis and Management of Ascaris-induced Acute Pancreatitis
Authors: Chen Yi-sheng, Den Ben-xian, Huang Bi-la, Xu Ling-zhen
Journal: Endoscopy (1986)

We report on 14 cases of endoscopically diagnosed and managed Ascaris-induced acute pancreatitis. Fifteen live adult ascarides were found in fourteen patients. Under direct endoscopic observation, all roundworms impacted in the papilla of Vater were grasped by the biopsy forceps and removed. After the endoscopic procedure, all the symptoms subsided, and laboratory data gradually returned to normal levels. We believe that this method is a safe procedure without complications or risk.
Cardiovascular Disease and Its Risk Factors in IDDM in Europe
Authors: V A Koivisto, I K Stevens, M Mattock, P Ebeling, M Muggeo, J Stephenson, B Idzior-Walus
Journal: Diabetes Care (1996)

OBJECTIVE To study the prevalence of cardiovascular disease (CVD), its risk factors, and their associations in IDDM patients in different European countries. RESEARCH DESIGN AND METHODS The prevalence of CVD (a past history or electrocardiogram abnormalities) and its risk factors were examined in a cross-sectional study in 3,250 IDDM patients from 16 European countries (EURODIAB IDDM Complications Study). The patients were examined in 31 centers and were stratified between centers for age, sex, and duration of diabetes. The mean ± SD duration of diabetes was 14.7 ± 9.3 years. RESULTS The prevalence of CVD was 9% in men and 10% in women. The prevalence increased with age (from 6% in patients 15–29 years old to 25% in patients 45–59 years old) and with duration of diabetes. The between-center variation for the whole population was from 3 to 19%. In both sexes, fasting triglyceride concentration was higher and HDL cholesterol lower in those patients with CVD than in those without. In men, duration of diabetes was longer, waist-to-hip ratio greater, and hypertension more common in patients with CVD. In women, a greater BMI was associated with increased prevalence of CVD. There was no association between insulin dose, HbA1c level, age-adjusted rate of albumin excretion, or smoking status and CVD. Waist-to-hip ratio, particularly in men, was positively associated with age, age-adjusted HbA1c, prevalence of smoking, daily insulin dose, albumin excretion rate, and fasting triglyceride concentrations. CONCLUSIONS The overall prevalence of CVD in these IDDM patients was ∼ 10%, increasing with age and duration of diabetes and with a sixfold variation between different European centers. CVD prevalence was most strongly associated with elevated triglyceride and decreased HDL cholesterol concentrations. CVD was also associated with albuminuria, but when adjusted by age, this association vanished. Increasing waist-to-hip ratio was associated with a number of adverse characteristics, particularly in IDDM men, reflecting the metabolic syndrome previously described in other populations.
Antony Joseph Duggan
Authors: G C Cook
Journal: BMJ (2005)

Founder of the Northern Ireland Renal ServiceMollie McGeown overcame gender prejudice in 1950s Northern Ireland medicine to build a career that changed the lives of thousands of people affected by kidney failure.After completing an MD thesis on endocarditis followed by a PhD in biochemistry, she was awarded a five year Medical Research Council fellowship and went on to develop an international reputation in calcium metabolism, hyperparathyroidism, and kidney stone disease.In 1959 she was appointed to set up a dialysis service for Northern Ireland and carried out the first successful dialysis on a uraemic patient later that year.This was a pivotal moment for patients in Northern Ireland with kidney failure.Over 200 patients in Northern Ireland at that time died each year from this cause.In 1971 a young woman treated by Mollie for pregnancy related renal failure founded the Northern Ireland Kidney Research Fund, which has to date raised £3m (€4.38m; $5.6m).Mollie was the patron of this fund up to her death.
Hypothyroidism and Primary Pulmonary Hypertension
Authors: Jeffrey Fisher
Journal: Annals of Internal Medicine (1994)

Letters15 January 1994Hypothyroidism and Primary Pulmonary HypertensionJeffrey Fisher, MDJeffrey Fisher, MDThe New York Hospital-Cornell Medical Center; New York, NY 10021Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-2-199401150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In preparing their recent report of four patients with primary pulmonary hypertension and hypothyroidism, Badesch and colleagues [1] found no previous observation of this association.In 1986, we described three patients with primary pulmonary hypertension associated with hypothyroidism and six patients with hypothyroidism, pulmonary hypertension, and connective tissue disorders [2].In addition to an autoimmune pathogenesis, we noted the long-observed association between systemic hypertension and hypothyroidism and discussed potential humoral, thrombotic, and rheologic mechanisms that might provide a pathophysiologic link between hypothyroidism and pulmonary hypertension.However enticing the putative mechanisms may be, the association is not common ...References1. Badesch DB, Wynne KM, Bonvallet S, Voelkel NF, Ridgway C, Groves BM. Hypothyroidism and primary pulmonary hypertension: an autoimmune pathogenetic link? Ann Intern Med. 1993; 119:44-6. Google Scholar2. Chin RG, Fisher J. Hypothyroidism and pulmonary hypertension: observation and speculation. Cardiovascular Reviews and Reports. 1986; 7:789-95. Google Scholar Author, Article, and Disclosure InformationAffiliations: The New York Hospital-Cornell Medical Center; New York, NY 10021 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1994Volume 120, Issue 2Page: 167-168KeywordsConnective tissueHypertensionHypothyroidismPathogenesisPulmonary hypertensionThyroid Issue Published: 15 January 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Screening Tests for Urinary Uroporphyrin
Authors: Richard S. Goodman, Leonard J. Lyon
Journal: JAMA (1962)

Elevation of urinary uroporphyrin occurs regularly in the porphyrias and is a relatively specific phenomenon. Urinary uroporphyrin must be purified and concentrated for qualitative demonstration at low but clinically significant levels. A new procedure based on the adsorption of uroporphyrin to talc, its insolubility in ether, and its brilliant red fluorescence under ultraviolet light is a rapid and highly sensitive screening test. Unlike other methods now in use, this test is significant when negative. Urine specimens from 12 patients with porphyria and 74 of 75 random hospital specimens of urine containing 50 to 100 mcg. per liter of added uroporphyrin gave positive tests while weak positive reactions were seen in only 6 of the same 75 specimens without added uroporphyrin.
Effect of trampoline-based intervention program in static balance of children with developmental coordination disorder
Authors: M Mitsiou, M Sidiropoulou, P Giagkazoglou, V Tsimaras
Journal: British Journal of Sports Medicine (2011)

Published studies have shown that the presence of developmental coordination disorder (DCD) (APA,1994), involves about 5–15% of the population. This work focused on the study of the effect of an intervention program with trampoline on school children of ages from 6 to 11 years old, exhibiting DCD. The study included DCD detection with the quantitative diagnosis test of neuromuscular coordination of the entire body (Körperkoordinationstest für Kinder KTK, Kiphard &amp; Schilling, 2002, 1974), leading to 20 (out of a total of 200) children exhibiting DCD (intervention and control groups). Furthermore, a group of 10 students constituted a control group without DCD. A static balance measurement test was applied, using the balance platform (footchecker 3.2, Lovan Engineering S.r.l., Bologna, Italy) for all 30 students as follows: standing with open and closed eyes, and balance maintenance while standing on each one foot for 30″. An intervention program for multifaceted practicing of coordination abilities with trampoline was also applied to the intervention group, whereas the control groups followed the typical physical education timetable. An important effect of the intervention group (p&lt;0.001), regarding the SD of the centre of pressure (CP) in the anteroposterior axis (Y), was observed during measurement with open eyes and standing on the right foot, as well as in the collateral axis (X), while standing on the left foot. A statistically significant difference (p&lt;0.001) was also exhibited in the Y-axis, concerning the shifting of the CP, for the case of measurement with open eyes and standing on each foot. Regarding the within groups interaction, a significant effect (p&lt;0.05) was observed for the shifting of the CP along the Y-axis for all conditions of measurement. These results support the hypothesis that the use of trampoline may improve the neuromuscular coordination, hence could provide a valid diagnostic tool for DCD.
Von Willebrand Syndromes and Mitral-Valve Prolapse
Authors: Nancy J. Pickering, Jerome I. Brody, Michael J. Barrett
Journal: New England Journal of Medicine (1981)

We searched for mitral-valve prolapse by two-dimensional echocardiography in 15 patients with von Willebrand syndromes to test the hypothesis that this bleeding disorder is actually a mesenchymal dysplasia that resembles the heritable disorders of connective tissue. This valvular abnormality was found in nine (60 per cent) of these patients, as compared with four (13.3 per cent) of 30 sex-matched and age-matched healthy controls. This difference was statistically significant (P less than 0.01). The association between these two disorders encourages a search for mitral-valve prolapse in persons with a von Willebrand syndrome. The complex of a von Willebrand syndrome and mitral-valve prolapse may be an example of a newly recognized category of related coagulation and cardiovascular disorders.
Reply to Ulbricht et al.
Authors: N. Tsesmeli, D. Coumaros
Journal: Endoscopy (2010)

We appreciate the interest and kind comments of Dr. Ulbricht and colleagues on our review on intragastric balloons for weight reduction. Their letter reports a case of severe pulmonary disease as a possible extraesophageal complication of gastroesophageal reflux disease (GERD) associated with intragastric balloon implantation.
Chest X-ray Screening For Tuberculosis
Authors: ASHER J. Finkel
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Dr. Jacobs has provided a number of critical comments on my statement with regard to college-entrace chest x-ray examinations. My statement at the outset pointed out that the American Medical Association has not established any policies or recommendations concerning routine screening or chest x-ray examinations, and my identification with the AMA Department of Environmental, Public, and Occupational Health was not meant to imply that my comments represented the policy of the Department or of the AMA. Dr. Jacobs is quite right in pointing out that the tuberculin test is a much more efficient method of screening apparently healthy young adults for pulmonary tuberculosis than a chest x-ray examination. In my brief comments, I simply wanted to point out that a single chest roentgenogram taken with a properly collimated beam did not provide a serious radiation hazard to the patient or entering college student. I did not intend
Update: Pulmonary Diseases and Disorders
Authors: William R. Barclay
Journal: JAMA (1983)

This book updates the two-volume text by Fishman and coauthors published in 1980. However, one need not possess the parent text to make this a worthwhile purchase, for it provides complete and detailed information on a limited number of selected topics. Twenty-seven topics were selected for this update because substantial new information was available, or the topic had become of great public or professional interest. Examples are chapters on pneumococcal vaccine, short-course therapy for tuberculosis, management of small cell carcinoma of the lung, fatigue of the diaphragm, computed axial tomography, asbestosis, silicosis, sleep disorders, and pharmacologic therapy for asthma. Each topic is discussed in great detail, with emphasis on how clinical findings relate to physiological and pathological changes and on how these changes determine what constitutes rational therapy. Each chapter has an extensive, up-to-date bibliography. The roentgenographic illustrations are outstanding because of their large size, usually half a page, and
Absence of Tolbutamide Effect on Anticoagulant Therapy
Authors: Russell L. Poucher
Journal: JAMA (1966)

Data on 224 diabetic patients were collected to determine the effect of tolbutamide (Orinase) on coumarin anticoagulant therapy and prothrombin times, using insulin injection-treated diabetic patients as controls. This retrospective survey indicates that there is no potentiating or inhibitory effect of tolbutamide, as compared to insulin, on anticoagulant therapy. When tolbutamidetreated patients were compared, there was no statistically (or clinically) significant difference at the 0.05 level or beyond, with respect to average initial dosage or maintenance dosage of anticoagulant, and day 4 and average prothrombin time. Likewise, there was no significant difference between treatment groups in the number of patients who were "adequately" maintained on anticoagulants. In conclusion, this study fails to demonstrate a difference in effect between tolbutamide and insulin on anticoagulant therapy, either potentiating or inhibitory.
Fetal Effects of Metoclopramide Therapy for Nausea and Vomiting of Pregnancy
Authors: Matitiahu Berkovitch, Daniel Elbirt, Antony Addis, Lavinia Schuler-Faccini, Asher Ornoy
Journal: New England Journal of Medicine (2000)

To the Editor: Many pregnant women have nausea and vomiting during the first trimester; these effects may be severe and in some women they continue beyond the first trimester.1 The cause is likely ...
Historical perspective on nutritional support of cancer patients
Authors: E. M. Copeland
Journal: CA A Cancer Journal for Clinicians (1998)

Initially, total parenteral nutrition (TPN) was not used in cancer patients because of the fear of sepsis and the potential for stimulation of tumor growth. It was used first in cancer patients who had failed all attempts at enteral nutrition and in whom adequate anticancer therapy would have been otherwise impossible. TPN candidates today remain patients with responsive tumors who cannot tolerate the toxicity of cancer therapy because they are malnourished.
Latent Osteomalacia in Epileptic Patients on Anticonvulsants
Authors: C. Christiansen, M. Kristensen, P. Rodbro
Journal: BMJ (1972)

The bone mineral content was measured in 10 epileptic patients on long-term treatment with phenytoin before and during treatment with vitamin D. None of the patients showed biochemical signs of osteomalacia. Initially subnormal values for bone mineral content were found, which increased significantly during treatment. The results suggest the occurrence of latent osteomalacia in a fairly high proportion of epileptic patients on anticonvulsants.
BRONCHIOGENIC CARCINOMA WITH CEREBRAL METASTASIS IN A PATIENT WITH KYPHOSIS
Authors: Mitchell Bernstein
Journal: JAMA (1930)

The diagnosis of intrathoracic cancer in a patient with a deformed chest obviously offers many difficulties. This is especially true in a patient with thoracic deformity when the subjective symptoms suggest the diagnosis of pulmonary tuberculosis with atypical signs. In addition, the pathologic involvement of several cranial nerves further complicates the clinical picture. However, the diagnosis of possible pulmonary cancer with cerebral metastasis, as occurred in the case herein reported, should not be overlooked. <h3>REPORT OF CASE</h3><h3>History.</h3> —E. C., a man, aged 48, was admitted to the service of Dr. Bernard Kohn at the Jewish Hospital, Jan. 29, 1930, because of a chronic productive cough together with weakness, night sweats, slight fever and headache. These symptoms had existed for about four weeks prior to admission. During infancy the patient sustained an injury to the upper spine, the exact nature of which was unknown. This injury supposedly resulted in the
Radiology in Bone Pathology
Authors: Joseph Hanelin, Laurence L. Robbins
Journal: New England Journal of Medicine (1951)

Pseudotumors An intermediate group of lesions that fail to find a definite categorical "home" have been given the prefix of "pseudo- ." Under this heading fall certain conditions in which diagnosis is important in order to prevent unnecessary surgery, especially amputation. Bone changes accompanying hemophilia and pseudohemophilia89 , 90 exemplify this.In certain anemias, such as the Mediterranean types and hemolytic jaundice, extramedullary hematopoiesis with bone structure may take place in unusual areas, — heterotopic bone marrow in paraspinal areas, for instance.91 These masses of heterotopic bone marrow are considered compensatory and are not malignant tumors. They may, however, be mistaken for . . .
The Making and Unmaking of a Journal
Authors: Frank Davidoff
Journal: Annals of Internal Medicine (1999)

Editorials4 May 1999The Making and Unmaking of a JournalFrank Davidoff, MDFrank Davidoff, MDEditor: Frank Davidoff, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-9-199905040-00019 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Much has been made of the recent firing of George Lundberg, the editor of the Journal of the American Medical Association (JAMA) for 17 years. We've heard about timing the publication of papers on "hot" topics, the seeking of media attention, the intrusion of political agendas into scientific journal publishing. We've reacted strongly to strong personalities, puzzled over who should hire and fire journal editors, and rethought the principle of editorial freedom that underlies it all (1-5). What's gotten lost in all the shouting about personalities and principles, unfortunately, is the pragmatic issue of how hard it is to build ...References1. McCullogh M. "Sex," politics clash at a medical journal. Philadelphia Inquirer. 16 January 1999:A1. Google Scholar2. Horton R. The sacking of JAMA . Lancet. 1999;353:252-3. CrossrefMedlineGoogle Scholar3. Smith R. The firing of Brother George. The AMA has damaged itself by sacking JAMA's editor. BMJ. 1999;318:210. CrossrefMedlineGoogle Scholar4. Kassirer JP. Should medical journals try to influence political debates? N Engl J Med. 1999;340:466-7. CrossrefMedlineGoogle Scholar5. Wolinsky H. Medical editors rip AMA over firing. Chicago Sun-Times. 25 January 1999. Google Scholar6. Wilson EO. Consilience: The Unity of Knowledge. New York: Knopf; 1998:59. Google Scholar7. Senge P. The Fifth Discipline: The Art and Practice of the Learning Organization. New York: Doubleday; 1990:68-92. Google Scholar8. Davidoff F. New disease, old story [Editorial]. Ann Intern Med. 1998;129:327-8. LinkGoogle Scholar9. JAMA and editorial independence. JAMA Editors, AMA Archives Journals Editors, JAMA Editorial Board Members. JAMA. 1999; 281:460. Google Scholar10. Booth B. Search for JAMA editor starts with policy review. AM News. 2 February 1999. Google Scholar Author, Article, and Disclosure InformationAffiliations: Editor: Frank Davidoff, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPublishing ethics and integrityAchieving a balanceThe Role of a Journal in a Scientific ControversyEditorial independence at medical journals owned by professional associations: A survey of editorsEditorial independence is built on trust and communicationThe Evolution of Mayo Clinic Proceedings 4 May 1999Volume 130, Issue 9Page: 774-775KeywordsExerciseInformation technologyPersonalitySystematic reviews Issue Published: 4 May 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.Loading ...
Small-bowel endoscopy
Authors: C. Teshima, P. Mensink
Journal: Endoscopy (2010)

Capsule endoscopy and double-balloon enteroscopy (DBE) have similar diagnostic yields for the evaluation of small-bowel diseases [2]. Some of the unique advantages of capsule endoscopy, such as its less invasive nature, superior tolerability and, in theory, complete visualization of the small-bowel mucosa, dictates that capsule endoscopy is the preferred first-line investigation in patients with suspected small-bowel pathology [3]. However, capsule endoscopy is limited by the inability to perform real-time assessments and biopsy sampling or therapeutic interventions on detected lesions, for which small-bowel enteroscopy is needed. Thus, DBE or single-balloon enteroscopy (SBE) often needs to be performed after capsule endoscopy, guided by the capsule results.
The Public's Response to the 2009 H1N1 Influenza Pandemic
Authors: Gillian K. SteelFisher, Robert J. Blendon, Mark M. Bekheit, Keri Lubell
Journal: New England Journal of Medicine (2010)

In April 2009, a novel influenza A (H1N1) virus emerged in the United States with the key characteristics of a pandemic virus, and within weeks it had spread to every region in the country.1 Ultimately, the rate of death was lower than was initially predicted, but the numbers of H1N1 cases, hospitalizations, and deaths were nonetheless substantial,2 and the experience offers some lessons that may help us to prepare for future influenza outbreaks. Given the crucial role that the public plays in containing or spreading illness and in seeking related medical care, we have examined the public's response to the . . .