ON THE ETIOLOGY OF CANCER—COCARCINOGENIC AGENTS
Authors: F. H. J. FIGGE
Journal: Annals of Internal Medicine (1947)

Editorial1 July 1947ON THE ETIOLOGY OF CANCER—COCARCINOGENIC AGENTSF. H. J. FIGGEF. H. J. FIGGESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-1-143 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the fifteen years that have elapsed since the isolation of the carcinogenic substance benzpyrene from coal tar (Cook, Hewett, Hieger1), a relatively large number of substances have been tested for their cancer-producing potentialities. Cook and Kennaway2, 3surveyed the most important work up until 1938 and listed 860 papers in the bibliography. Over 1,000 compounds have been listed in a recent revision of Hartwell's extensive survey4of compounds that have been tested for carcinogenicity. Two hundred and sixty-four, or approximately one-fourth of the substances tested, have been shown to induce cancer. In the early part of this work on...1 COOKHEWETTHIEGER JWCLI: The isolation of a cancer-producing hydrocarbon from coal tar. Parts I, II and III, Jr. Chemical Soc., 1933, p. 395. CrossrefGoogle Scholar2 COOKKENNAWAY JWEL: Chemical compounds as carcinogenic agents. First supplementary report: Literature of 1937, Am. Jr. Cancer, (Bibliography), 1938, xxxiii, 50. CrossrefGoogle Scholar3 COOKKENNAWAY JWEL: Chemical compounds as carcinogenic agents. Second supplementary report: Literature of 1938 and 1939, Am. Jr. Cancer, 1940, xxxix, 381, 521. Google Scholar4 HARTWELL JL: Survey of compounds which have been tested for carcinogenic activity, Nat. Inst. Health, Nat. Cancer Inst., U. S. Pub. Health Service, Bethesda, Md., 1941. Google Scholar5 NONAKA T: The occurrence of subcutaneous sarcomas in the rat after repeated injections of glucose solution, Gann, 1938, xxxii, 234. Google Scholar6 FIGGE FH: The relationship of pyrrol compounds to carcinogenesis, A.A.A.S. Research Conference on Cancer, edited by F. R. Moulton, Science Press Printing Co., Lancaster, Pa., 1945, 117-128. Google Scholar7 ENGLEKRAKOWERHAAGENSEN ETCCD: Estrogen administration to aged female monkeys with no resultant tumors, Cancer Res., 1943, iii, 858-866. Google Scholar8 ALLEN E: Report of activities during 1940 (p. 8), Report of activities during 1941 (p. 24), International Cancer Research Foundation. Google Scholar9 FIGGE FH: Fluorescence studies on cancer. I. Porphyrin metabolism, Harderian gland fluorescence, and susceptibility to carcinogenic agents, Cancer Res., 1944, iv, 465-470. Google Scholar10 JONESFIGGEHUNDLEY EGFHJM: Fluorescence studies on cancer. II. The red fluorescence of the genitalia of women, Cancer Res., 1944, iv, 472-482. Google Scholar11 FIGGEJONESWOLFE FHEGGF: Fluorescence studies on cancer. III. The extraction and identification of porphyrins from the red-fluorescent exudates on the genitalia of women, Cancer Res., 1944, iv, 483-486. Google Scholar12 SHEAR MJ: Studies in carcinogenesis: methyl derivatives of 1:2-benzanthracene, Am. Jr. Cancer, 1938, xxxiii, 499-537. CrossrefGoogle Scholar13 SALLSHEAR RDMJ: Studies on carcinogenesis. XII. Effect of the basic fraction of creosote oil in the production of tumors in mice by chemical carcinogens, Jr. Nat. Cancer Inst., 1940, i, 45-55. Google Scholar14 BERENBLUM I: The cocarcinogenic action of croton resin, Cancer Res., 1941, i, 44-48. Google Scholar15 BIELSCHOWSKY F: Distant tumors produced by 2-amino and 2-acetyl-amino-fluorene, Brit. Jr. Exper. Path., 1944, xxv, 1-4. Google Scholar16 BIELSCHOWSKY F: Tumors of the thyroid produced by 2-acetyl-amino-fluorene and allyl-thiourea, Brit. Jr. Exper. Path., 1944, xxv, 90-94. Google Scholar17 FIGGE FH: Cosmic radiation and cancer, Science, 1947, cv, 323-325. CrossrefGoogle Scholar18 EUGSTERHESS IVF: Weltraumstrahlung und ihre biologische Wirkung, 1940, Orell Füssli Verlag, Zurich-Leipzig. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiagnostic Application of Fluorescence Spectroscopy in Oncology Field: Hopes and ChallengesLaser-induced fluorescence detection of malignancies in the female genital tract via their natural emission and hypocrellin (HA) probingMalignancies and atherosclerotic plaque diagnosis—is laser induced fluorescence spectroscopy the ultimate solution?TUMOR LOCALIZERS: PORPHYRINS AND RELATED COMPOUNDS (UNUSUAL METALLOPORPHYRINS XXIII)Malignant tumors of the uterine fundus subsequent to irradiation for benign pelvic conditionsCorpus cancer.Clinical, pathological, and etiological aspects 1 July 1947Volume 27, Issue 1Page: 143-146KeywordsEtiology Issue Published: 1 July 1947 PDF downloadLoading ...