tbuckley/cabot-search huggingface dataset:
Myocardial Ischemia with Normal Coronary Arteries Associated with Thoracic Myelitis
Authors: Wolfgang Lalouschek, Christian Müller, Gunnar Gamper, Michael Weissel, Karl Turetschek
Journal: New England Journal of Medicine (1997)

To the Editor: Cardiac adrenergic signals have an important role in regulating cardiac function and myocardial blood flow.1,2 We describe a patient with normal coronary arteries who had angina at rest, which was associated with myelitis of the thoracic spinal cord, including the origin of the cardiac sympathetic nerves. A nonsmoking 53-year-old woman with a history of mild arterial hypertension was admitted to our hospital for a severe episode of angina at rest. Electrocardiography revealed a horizontal ST-segment depression up to 3 mm in leads V2 through V6. Transthoracic echocardiography showed anteroseptal hypokinesia. Treatment with intravenous nitroglycerin and heparin . . .
Myeloid Cell-Derived Reactive Oxygen Species Externally Regulate the Proliferation of Myeloid Progenitors in Emergency Granulopoiesis
Authors: Hyun-Jeong Kwak, Peng Liu, Besnik Bajrami, Yuanfu Xu, Shin-Young Park, César Nombela-Arrieta, Subhanjan Mondal, Yan Sun, Haiyan Zhu, Li Chai, Leslie E. Silberstein, Tao Cheng, Hongbo R. Luo
Journal: Immunity (2015)
Republished editorial: Physical activity for cancer survivors: Beneficial in the short term, but longer term outcomes are lacking
Authors: Liam Bourke, Derek Rosario, Robert Copeland, Stephanie Taylor
Journal: British Journal of Sports Medicine (2013)

▸ This article is an abridged version of a paper that was published on bmj.com. Cite this article as: BMJ 2012; 344 :e7998

In 2008, more than 12 million people worldwide were diagnosed with cancer (http://globocan.iarc.fr/). Because of improvements in early diagnosis and the introduction of more aggressive treatments over the past 20 years, cancer survivors are now living longer.1 However, treatment often leads to a range of undesirable and debilitating adverse effects.

In the linked meta-analysis, Fong and colleagues assess the effects of physical activity after treatment for cancer on 48 separate health related outcomes.2 The potential for exercise interventions to benefit survivors of cancer is a burgeoning area of research, and systematic reviews and meta-analyses have reported that exercise can reduce fatigue and improve functional outcomes and health related quality of life.3⇓–5 These reports have also called for larger trials that have a greater focus on study quality and adverse events and longer follow-up.

Fong and colleagues' meta-analysis reviewed 34 randomised trials (of which 22 were …
Inequality in child health is greatest in Hungary, least in Netherlands, shows study of rich countries
Authors: J. Zarocostas
Journal: BMJ (2010)

Italy, the United States, Greece, and the United Kingdom are letting their most vulnerable and disadvantaged children fall further behind children in other wealthy countries, including in terms of health, a Unicef report says.

More focused efforts are needed to reduce inequality, says Unicef. It warns that tough austerity measures and social spending cuts imposed by many governments to combat deficits could see the situation worsen.

The report ranks 24 countries in the Organisation for Economic Co-operation and Development in terms of children’s equality in health, education, and material wellbeing. Ranked top overall, Denmark, Finland, the Netherlands, and Switzerland “are leading the way in promoting equality” in children’s …
Combined use of fasting plasma glucose and HbA1c predicts the progression to diabetes in Chinese subjects.
Authors: G T Ko, J C Chan, L W Tsang, C S Cockram
Journal: Diabetes Care (2000)

OBJECTIVE: We have previously suggested using the paired values of fasting plasma glucose (FPG) and HbA1c to identify potential diabetic subjects. In this article, we followed up on 208 nondiabetic subjects and examined their rates of progression to diabetes. We analyzed their likelihood of becoming diabetic according to their baseline FPG and HbA1c concentrations. RESEARCH DESIGN AND METHODS: Between 1988 and 1995, 2,877 Chinese subjects with risk factors for diabetes underwent screening. Of these, 2,250 had FPG &amp;lt;7.8 mmol/l and 2-h plasma glucose (PG) &amp;lt;11.1 mmol/l. Of these 2,250 subjects, 265 were randomly recruited for an annual oral glucose tolerance test (OGTT) until they progressed to develop diabetes. Of those 265 subjects, 57 had baseline FPG &amp;gt; or =7.0 mmol/l and were excluded from the present analysis. Hence, the progression of glucose tolerance in 208 subjects who were nondiabetic according to the new American Diabetes Association diagnostic criteria (FPG &amp;lt; 7.0 mmol/l and 2-h PG &amp;lt; 11.1 mmol/l) was examined RESULTS: Of the 208 nondiabetic subjects, 26 (12.5%) were men and 182 (87.5%) were women. After a mean follow-up of 1.60 +/- 1.16 years (range 1-7, median 1), 44 (21.2%) progressed to develop diabetes and 164 (78.8%) remained nondiabetic. Those who were diabetic at the end of the study had a high likelihood ratio (LR) of 9.3 to have baseline FPG &amp;gt; or =6.1 mmol/l and baseline HbA1c &amp;gt; or =6.1%. This was compared with a low LR of 0.6-1.1 in diabetic subjects who had either FPG &amp;lt;6.1 mmol/l or HbA1c &amp;lt;6.1% or both at baseline. The crude rate of progression to diabetes was more than five times higher (44.1 vs. 8.1%) in those whose baseline FPG was &amp;gt; or =6.1 mmol/l and baseline HbA1c was &amp;gt; or =6.1% compared with those whose baseline FPG was &amp;lt;6.1 mmol/l and baseline HbA1c was &amp;lt;6.1%. CONCLUSIONS: For Chinese subjects with risk factors for glucose intolerance, the use of paired FPG and HbA1c values helped to identify potential diabetic subjects. Those with an FPG &amp;gt; or =6.1 mmol/l and HbA1c &amp;gt; or =6.1% had a rate of progression to diabetes more than five times higher than those with an FPG &amp;lt;6.1 mmol/l and an HbA1c &amp;lt;6.1% after a mean follow-up of 1.6 years. Those with an FPG &amp;gt; or =6.1 but &amp;lt;7.0 mmol/l, especially if their HbA1c was &amp;gt; or =6.1%, should undergo an OGTT to confirm diabetes. Subjects with an FPG &amp;lt;6.1 mmol/l and/or an HbA1c &amp;lt;6.1% should have regular screening using the paired values of FPG and HbA1c.
Direct Lymphatic Drainage From the Skin of the Forearm to a Supraclavicular Node
Authors: ROGER F. UREN, ROBERT HOWMAN-GILES, JOHN F. THOMPSON, MICHAEL J. QUINN
Journal: Clinical Nuclear Medicine (1996)

Lymphoscintigraphy with Tc-99m antimony sulfur colloid was performed on a patient with cutaneous melanoma of the left forearm to define the sentinel nodes before surgery. The patient was found to have direct lymphatic drainage from the left forearm through a clearly seen lymph channel to a sentinel lymph node in the left supraclavicular fossa, and drainage through a separate channel to two sentinel nodes in the left axilla. Surprising patterns of lymphatic drainage can be seen from the forearm, as well as other parts of the skin, and lymphoscintigraphy will enable such patients to be identified before sentinel node biopsy.
Immunity for expert witnesses is under threat from a case coming to Supreme Court
Authors: C. Dyer
Journal: BMJ (2010)

Expert witnesses could lose their long standing immunity from being sued for negligence, in a test case that goes to the UK Supreme Court on 11 January.

The case has been brought against a consultant clinical psychologist, but the judges’ eventual ruling will apply to all expert witnesses.

Paul Wynne Jones sued psychologist Sue Kaney, his own expert witness in a road traffic incident case, claiming that he had to settle the case for substantially less than expected because of …
Circadian Variation of Paroxysmal Atrial Fibrillation
Authors: Takeshi Yamashita, Yuji Murakawa, Kazunori Sezaki, Masashi Inoue, Noriyuki Hayami, Yutaka Shuzui, Masao Omata
Journal: Circulation (1997)

Background Circadian variation in the incidence of acute cardiovascular events is well known but has not been extensively investigated in paroxysmal atrial fibrillation, although the significance of this arrhythmia is growing in our society with the increasing number of aged people. Methods and Results We detected 150 patients with paroxysmal atrial fibrillation in a drug-free state from among 25 500 consecutive Holter recordings. To determine whether the onset, maintenance, and termination of paroxysmal atrial fibrillation were random events, we analyzed the total recorded duration of arrhythmia and the incidence of and number of patients with the onset, maintenance, and termination of this arrhythmia as hourly data and as hourly probabilities. A prominent circadian rhythm of the total duration of atrial fibrillation, ≈90% of which was well explained by a single cosinusoidal function, was detected with a nadir around 11 am . Because the onset of the arrhythmia had little or no circadian rhythm, this finding was due to a diurnal pattern of maintenance and termination, both of which were well expressed by a double-harmonic density function. Maintenance showed a trough at 11 am, and termination showed a peak at the same time, leading to the nonuniform duration of single episodes of atrial fibrillation throughout the 24-hour day. Conclusions Paroxysmal atrial fibrillation showed a unique circadian variation that differed from the well-known pattern for acute cardiovascular events, a point that should be kept in mind when antiarrhythmic therapy is evaluated. Identification of factors that regulate the circadian pattern of the maintenance and termination of paroxysmal atrial fibrillation may lead to better chronotherapy for preventing perpetuation of this arrhythmia.
(21) Pili torti
Authors: J.B. Lyon
Journal: British Journal of Dermatology (1975)

Journal Article (21) Pili torti Get access J.B. Lyon J.B. Lyon Ipswich Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 93, Issue s11, 1 July 1975, Page 64, https://doi.org/10.1111/j.1365-2133.1975.tb06804.x Published: 01 July 1975
Unilateral Edema and Jaundice, and Pope
Authors: ROBERT M. ROSA
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 November 1972Unilateral Edema and Jaundice, and PopeROBERT M. ROSA, M.D.ROBERT M. ROSA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-5-818_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Shortly after the unusual association of unilateral edema and jaundice after portacaval anastomosis was reported (1), I saw a variant of this syndrome.The patient was a 44-year-old man with decompensated Laennec's cirrhosis and alcoholic hepatitis who had undergone several paracenteses, all in the right side of the abdomen, for diagnosis and for the relief of extremely tense ascites, which was causing him pain and moderate dyspnea. Three days after the last tap the patient, who preferred to lie on his right side, noted edema of the right lower leg. In addition, there was some edema of...References1. CONN H: Unilateral edema and jaundice after portacaval anastomosis. Ann Intern Med 76:459-461; 1972 LinkGoogle Scholar2. CONN H: Sudden scrotal edema in cirrhosis: a postparacentesis syndrome. Ann Intern Med 74:943-945, 1971 LinkGoogle Scholar3. MADDREYKLINEFELTER WH: Edema and diuresis from peritoneal biopsy (letter). Ann Intern Med 76:1044, 1972 LinkGoogle Scholar4. POPE A: An Essay on Criticism. Part II, 11. 558-559 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Yale University School of Medicine New Haven, Conn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1972Volume 77, Issue 5Page: 818-818KeywordsAbdominal painAlcoholicsAscitesCirrhosisDyspneaEdemaHepatitis APatient advocacy Issue Published: 1 November 1972 PDF DownloadLoading ...
Burns, Shock, and Plasma Volume Regulation
Authors: R. D. Liechty
Journal: JAMA (1968)

For fresh ideas of clinical importance, few recent medical books surpass this one. Treatment of the burn wound with topical silver nitrate solution is the most important innovation. Inexpensive and safe, AgNO<sub>3</sub>solution (at 0.5% cocentration) approaches the ideal burn wound antiseptic. Higher concentrations kill epidermis; lower concentrations fail to suppress bacteria. At this ideal concentration, the bacteriostatic covering, in contrast to septic occlusive dressings, permits epithelial regeneration of many deep second-degree burns. Also useful in treating extensive third-degree burns, AgNO<sub>3</sub>dressings "perform all these functions (of homografts)... without the woundmess of the rejection phenomenon." The authors emphasize technique in applying AgNO<sub>3</sub>dressings. Continuous thick wet dressings with a<i>dry</i>covering prevent vaporizational heat loss, yet sustain diffusion of the AgNO<sub>3</sub>to the burn wound. Because 0.5% AgNO<sub>3</sub>is hypotonic, electrolyte losses may be dangerous in the early stages of a burn. Much of this
Serum Total Cholesterol Concentrations and Awareness, Treatment, and Control of Hypercholesterolemia Among US Adults
Authors: Earl S. Ford, Ali H. Mokdad, Wayne H. Giles, George A. Mensah
Journal: Circulation (2003)

Serum cholesterol concentrations have decreased in the US population. Whether the decline continued during the 1990s is unknown.We used data from 4148 men and women aged > or =20 years who had a total cholesterol determination or reported using cholesterol-lowering medications and who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2000 (this is a cross-sectional health examination survey of the US population), and we compared the results with data from 15 719 participants in NHANES III (1988 to 1994). For all adults, the age-adjusted mean total cholesterol concentration decreased from 5.31 mmol/L (205 mg/dL) in NHANES III to 5.27 mmol/L (203 mg/dL) in NHANES 1999 to 2000 (P=0.159). The age-adjusted mean total cholesterol concentration decreased by 0.02 mmol/L (0.7 mg/dL) among men (P=0.605) and 0.06 mmol/L (2.3 mg/dL) among women (P=0.130). Significant decreases were observed among men aged > or =75 years, black men, and Mexican-American women. Among participants who had a total cholesterol concentration > or =5.2 mmol/L (200 mg/dL) or who reported using cholesterol-lowering medications, 69.5% reported having had their cholesterol checked, 35.0% were aware that they had hypercholesterolemia, 12.0% were on treatment, and 5.4% had a total cholesterol concentration <5.2 mmol/L (200 mg/dL) after age adjustment.The mean serum total cholesterol concentration of the adult US population in 1999 to 2000 has changed little since 1988 to 1994. The low percentage of adults with controlled blood cholesterol concentration suggests the need for a renewed commitment to the prevention, treatment, and control of hypercholesterolemia.
Adverse Occurrences in the Intensive Care Unit
Authors: Joseph M. Merrill, Eugene V. Boisaubin
Journal: JAMA (1981)

To the Editor.—  Inasmuch as we have been studying the frequency of human error in the emergency center as a basis for improving the quality of medical care, we welcome this splendid article (1980;244:1582) that recommends vigorous investigation of hazards in hospital.  We would like to call the attention of the Pittsburgh group to the well-documented diurnal rise in human error that peaks at about 3 AM and 3 PM. This interesting phenomenon has been confirmed in a variety of settings including gas company personnel reading meters, automatic train breakers, and near-misses in train and truck operators. It is perhaps more pertinent to point out that at 3 PM, detection of hypertension in the emergency center of a university-affiliated public general hospital fell to one third its previous rate. 1 We would like the authors' opinion as to the relevance of these findings to their observation that intensive care unit
Factors Associated With a Malignant or Benign Course of Multiple Sclerosis
Authors: Virginia A. Clark
Journal: JAMA (1982)

Eight hundred thirty-four patients with multiple sclerosis (MS) in King and Pierce Counties, Washington, and in Los Angeles County, California, with symptomatic onset between 1960 and 1969 were followed up for disability status in 1980. A higher proportion of the 375 patients who were not walking or deceased in 1980 had a late age of onset, resided in Los Angeles County, had motor or coordination symptoms at onset, and reported adverse responses to heat exposure and favorable responses to cold exposure, whereas a higher proportion of the 299 patients still walking without aids had early onset age and vision, speech, or sensory symptoms, or all three, at onset. The results suggest (1) that both host factors (age at first manifestation of symptoms and types of symptoms at onset) and environmental factors (place of residence and exposure to heat and cold) are determinants of disease course and (2) that most patients with MS should avoid exposure to heat. (<i>JAMA</i>1982;248:856-860)
Sex related differences in short and long term prognosis after acute myocardial infarction: 10 year follow up of 3073 patients in database of first Danish verapamil infarction trial
Authors: S Galatius-Jensen, J Launbjerg, L S. Mortensen, J F. Hansen
Journal: BMJ (1996)

Objective : To re-examine the prevailing hypothesis that women fare worse than men after acute myocardial infarction. Design : 10 year follow up of all patients with confirmed acute myocardial infarction registered in the database of the Danish verapamil infarction trial in 1979-81. Setting : 16 coronary care units, covering a fifth of the total Danish population. Patients : 3073 consecutive patients with acute myocardial infarction, 738 (24%) women and 2335 (76%) men. Main outcome measures : Early mortality (before day 15). For patients alive on day 15: mortality, cause of death, admission with recurrent infarction, and mortality after reinfarction. Results : Early mortality increased significantly with age (P<0.0001) but was not significantly related to sex, with a 15 day mortality of 17% in women and 16% in men. Adjustment for age and sex simultaneously revealed a significant interaction (P=0.02) between these variables, with a greater increase with age in early mortality for men than for women (early mortality was equal for the two sexes at age 64 years). Ten year mortality in patients alive on day 15 was 58.8%. The overall age adjusted hazard ratio (95% confidence interval) for women versus men was 0.90 (0.80 to 1.01); 0.90 (0.78 to 1.04) for 10 year reinfarction (48.8%); and 0.98 (0.82 to 1.16) for 10 year mortality after reinfarction (82.3%). No difference in cause of death was found between the sexes. With a follow up of up to 10 years for patients alive on day 15 mortality, rate of reinfarction, and mortality after reinfarction increased with increasing age (P<0.0001). Conclusion : Sex by itself is not a risk factor after acute myocardial infarction. #### Key messages
Skin disease in pregnancy
Authors: S. Vaughan Jones, C. Ambros-Rudolph, C. Nelson-Piercy
Journal: BMJ (2014)

<h3>Background</h3> Childhood head injury has the potential for lifelong disability and burden. This study aimed to establish the association between admission to hospital for childhood head injury and early academic performance. <h3>Methods</h3> The Wales Electronic Cohort for Children (WECC) study is comprised of record-linked routinely collected data, on all children born or residing in Wales. Anonymous linking fields are used to link child and maternal health, environment and education records. Data from WECC were extracted for children born between September 1998 and August 2001. A Generalised Estimating Equation model, adjusted for clustering based on the maternal identifier as well as other key confounders, was used to establish the association between childhood head injury and performance on the Key Stage 1 (KS1) National Curriculum assessment administered to children aged 5–7 years. Head injury was defined as an emergency admission for &gt;24 h for concussion, skull fracture or intracranial injury prior to KS1 assessment. <h3>Results</h3> Of the 101 892 eligible children, KS1 results were available for 90 661 (89%), and 290 had sustained a head injury. Children who sustained an intracranial injury demonstrated significantly lower adjusted odds of achieving a satisfactory KS1 result than children who had not been admitted to hospital for head injury (adjusted OR 0.46, 95% CI 0.30 to 0.72). <h3>Conclusions</h3> The findings of this population e-cohort study quantify the impact of head injury on academic performance, highlighting the need for enhanced head injury prevention strategies. The results have implications for the care and rehabilitation of children admitted to hospital with head injury.
Use of GIS and Exposure Modeling as Tools in a Study of Cancer Incidence in a Population Exposed to Airborne Dioxin
Authors: A. Poulstrup, H.L. Hansen
Journal: Environmental Health Perspectives (2004)

In environmental health research there is a recognized need to develop improved epidemiologic and statistical methods for rapid assessment of relationships between environment and health. Exposure assessment is identified as a major challenge needing attention. In this study an exposure simulation model was used to delimit almost exactly in space and time an urban population exposed to airborne dioxin. A geographic information system (GIS) was used as the electronic environment in which to link the exposure model with the demographic, migration, and cancer data of the exposed population. This information is available in Denmark on an individual basis. Standardized incidence ratios (SIRs) for both men and women in 10-year age bands were calculated for three different exposure areas. Migration patterns were outlined. SIRs showed no excess of cancer incidences during the time span chosen (13 years; 1986-1998) in the whole exposed area or in the medium or higher polluted areas. The exposure model appeared very useful in selection of the appropriate exposure areas. The integration of the model in a GIS together with individual data on addresses, sex, age, migration, and information from routine health statistics (Danish Cancer Registry) proved its usefulness in demarking the exposed population and identifying the cancers related to that population. Less than one-third of the study population lived at the same address after 13 years of observation, and only half were still residing in the area, indicating migration of people as a major misclassification.