Virulence Factors Predict <i>Escherichia coli</i> Colonization Patterns among Human and Animal Household Members
Authors: Andrew C. Murray, Michael A. Kuskowski, James R. Johnson
Journal: Annals of Internal Medicine (2004)

Letters18 May 2004Virulence Factors Predict Escherichia coli Colonization Patterns among Human and Animal Household MembersAndrew C. Murray, BS, Michael A. Kuskowski, PhD, and James R. Johnson, MDAndrew C. Murray, BSFrom Veterans Affairs Medical Center and University of Minnesota; Minneapolis, MN 55417., Michael A. Kuskowski, PhDFrom Veterans Affairs Medical Center and University of Minnesota; Minneapolis, MN 55417., and James R. Johnson, MDFrom Veterans Affairs Medical Center and University of Minnesota; Minneapolis, MN 55417.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-10-200405180-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Urinary tract infection (UTI) is a common and costly problem for which better preventive measures are needed (1). The causative extraintestinal pathogenic Escherchia coli (ExPEC) strains usually derive immediately from the host's fecal flora (2); however, their proximal source is unknown. Sexual partners and household pets are candidate reservoirs (3, 4). Certain ExPEC virulence factors may promote host-to-host transmission (5). Delineation of within-household patterns of colonization and transmission of ExPEC could suggest new preventive options.Objective: To define E. coli colonization patterns in relation to virulence factors among an adult heterosexual couple and their cat.Methods ...References1. Russo TA, Johnson JR. Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem. Microbes Infect. 2003;5:449-56. [PMID: 12738001] CrossrefMedlineGoogle Scholar2. Grüneberg RN. Relationship of infecting urinary organism to the faecal flora in patients with symptomatic urinary infection. Lancet. 1969;2:766-8. [PMID: 4186020] CrossrefMedlineGoogle Scholar3. Johnson JR, Delavari P. Concurrent fecal colonization with extraintestinal pathogenic Escherichia coli in a homosexual man with recurrent urinary tract infection and in his male sex partner. Clin Infect Dis. 2002;35:65-8. [PMID: 12203187] CrossrefMedlineGoogle Scholar4. Johnson JR, Delavari P, Stell AL, Whittam TS, Carlino U, Russo TA. Molecular comparison of extraintestinal Escherichia coli isolates of the same electrophoretic lineages from humans and domestic animals. J Infect Dis. 2001;183:154-9. [PMID: 11106542] CrossrefMedlineGoogle Scholar5. Foxman B, Manning SD, Tallman P, Bauer R, Zhang L, Koopman JS, et al . Uropathogenic Escherichia coli are more likely than commensal E. coli to be shared between heterosexual sex partners. Am J Epidemiol. 2002;156:1133-40. [PMID: 12480658] CrossrefMedlineGoogle Scholar6. Wold AE, Caugant DA, Lidin-Janson G, de Man P, Svanborg C. Resident colonic Escherichia coli strains frequently display uropathogenic characteristics. J Infect Dis. 1992;165:46-52. [PMID: 1727897] CrossrefMedlineGoogle Scholar7. Caugant DA, Levin BR, Selander RK. Distribution of multilocus genotypes of Escherichia coli within and between host families. J Hyg (Lond). 1984;92:377-84. [PMID: 6376625] CrossrefMedlineGoogle Scholar8. Johnson JR, Russo TA. Extraintestinal pathogenic Escherichia coli: "the other bad E coli". J Lab Clin Med. 2002;139:155-62. [PMID: 11944026] CrossrefMedlineGoogle Scholar9. Dozois C, Johnson J. The place of P fimbriae in the emergence of Escherichia coli extraintestinal pathotypes. ASM News. 2000;66:262-3. Google Scholar10. O'Hanley P. Prospects for urinary tract infection vaccines.. In: Mobley HL, Warren JW, eds. Urinary Tract Infections: Molecular Pathogenesis and Clinical Management. Washington, DC: American Soc Microbiology Pr; 1996. Google Scholar Author, Article, and Disclosure InformationAuthors: Andrew C. Murray, BS; Michael A. Kuskowski, PhD; James R. Johnson, MDAffiliations: From Veterans Affairs Medical Center and University of Minnesota; Minneapolis, MN 55417.Acknowledgment: The authors thank Dave Prentiss for assistance with the images, Francene Lebahn for assistance with human subjects procedures, Nicholas Kaster and Adam L. Stell for technical assistance in the laboratory, and the study subjects for their participation.Grant Support: This material is based on work supported by Office of Research and Development, Medical Research Service, Department of Veterans Affairs and National Institutes of Health grant DK-47504 (Dr. Johnson). 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