tbuckley/cabot-search huggingface dataset:
The comparative effectiveness of isotonic and isokinetic strength trainings on quadriceps peak torque
Authors: Hitanshu Agnihotri
Journal: British Journal of Sports Medicine (2010)

The present study compares the effectiveness of isotonic and isokinetic exercises on peak torque of quadriceps in 45 healthy young males. The subjects were randomly assigned into three groups (n=15): group A – isotonic group, group B – isokinetic group, group C – control group. Peak torque of quadriceps at velocities of 220 and 100°/s was tested twice with a gap of 4 weeks using isokinetic dynamometer. Isotonic protocol included three sets of 10 repetitions at 50% 10 RM, 75% 10 RM and 100% 10 RM. The isokinetic protocol consisted of one set of 10 repetitions at velocities of 220, 160, 100 and 40°/s each. Each exercise protocol was performed thrice a week for 4 weeks with 1-min rest interval. The subjects in the control group were not prescribed any kind of exercise training. Paired t test showed significant changes at 220°/s (t=4.62, p&lt;0.001) and 100°/s (t=2.49, p&lt;0.05) in group A, at 220°/s (t=3.42, p&lt;0.05) in group B and non-significant changes at 220°/s (t=2.02, p&gt;0.05) and 100°/s (t=0.82, p&gt;0.05) in group C. Post-test one-way analysis of variance revealed significant changes at 220°/s (F= 4.47, p&lt;0.05). Isotonic exercises were found to be more effective than isokinetic exercises in increasing the peak torque at high velocity.
Results of Endoscopic Removal of Villous Tumors of the Colon
Authors: V.P. Strekalovsky
Journal: Endoscopy (1983)

The author analyses the results of endoscopic removal of 136 villous tumors of the colon in 125 patients. The tumors ranged from 2 cm to over 6 cm in size. In the article emphasis is placed on the fact that multi-stage interventions are mainly practiced in the removal of villous tumors.
Philadelphia chromosome-positive acute lymphoblastic leukemia secondary to chemoradiotherapy for Ewing sarcoma. Report of two cases and concise review of the literature
Authors: David S. Snyder, Anthony S. Stein, Margaret R. O'Donnell, Karl Gaal, Marilyn L. Slovak, Stephen J. Forman
Journal: American Journal of Hematology (2004)

Survivors of childhood solid tumors including Ewing sarcoma (ES) have an increased risk of secondary malignant neoplasms (SMNs) as a consequence of exposure to chemotherapy and/or radiation (see: Bhatia S, Sklar C. Nat Rev Cancer 2002;2:124-132). The most common hematologic SMNs are myelodysplasia (MDS) and acute myelogenous leukemia (AML). Acute lymphoblastic leukemia (ALL) is uncommon in this patient population, and Philadelphia chromosome positive (Ph+) ALL in particular, is rare. We report herein two cases of young adult patients who were both diagnosed with Ph+ ALL 19 years after successful treatment for ES with combined modality therapy. A review of the relevant literature follows the case reports.
Sarcoidosis and Beryllium Disease
Authors: JAMES E. CONE
Journal: Annals of Internal Medicine (1981)

Letters1 June 1981Sarcoidosis and Beryllium DiseaseJAMES E. CONE, M.D., M.P.H.JAMES E. CONE, M.D., M.P.H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-6-822_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Dr. Crystal (1) suggests that in modern clinical practice the diagnosis of sarcoidosis is usually unambiguous. This statement may, however, mislead readers who are confronted with a disease that at times closely resembles the clinical, pathologic, and radiologic presentation of sarcoidosis but that has a very different prognosis and potential for prevention: beryllium disease (2).An occupational history may be deceptive. Exposure to beryllium may occur without a worker's knowledge, due to maintenance of trade secrecy in industry or to exposure to material such as mineral ores contaiminated with beryllium at low, but nonetheless biologically significant, levels....References1. CRYSTAL R. Introduction, p. 73. In: CYRSTAL RG, moderator. Pulmonary sarcoidosis: a disease characterized and perpetuated by activated lung T-lymphocytes. Ann Intern Med. 1981;94:73-94. LinkGoogle Scholar2. SPRINCEKAZEMIHARDY NHH. Current (1975) problem of differentiating between beryllium disease and sarcoidosis. Ann NY Acad Sci. 1976;278:654-64. CrossrefMedlineGoogle Scholar3. DEODHARBARNAVAN ORDSTRAND SBH. A study of the immunologic aspects of chronic berylliosis. Chest. 1973;63:309-13. CrossrefMedlineGoogle Scholar4. . Beryllium Case Registry. Direct inquiries to Todd Frazier, M.D., Chief, Surveillance Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226. Google Scholar5. HARDY H. Beryllium disease: a clinical perspective. Environ Res. 1980;21:1-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: National Institute for Occupational Safety and Health Cincinnati, OH 45226 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClinical and Epidemiological Studies 1 June 1981Volume 94, Issue 6Page: 822-822KeywordsSarcoidosis Issue Published: 1 June 1981 PDF downloadLoading ...
Notification of communicable diseases.
Authors: B J Heap
Journal: BMJ (1991)

infection rises the number of doctors infected during their clinical duties will also rise.Despite this doctors have treated and will, I hope, continue to treat HIV positive patients as they would any other person.Ethics demands no less.Doctors put their own lives at risk.Can it be right that the few who succumb should be the only HIV positive group to be let down by the NHS?
Serodiagnosis of Dirofilarial Infection
Authors: Richard T. Davey, Thomas B. Nutman, Eric A. Otteson
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 September 1987Serodiagnosis of Dirofilarial InfectionRICHARD T. DAVEY JR., M.D., THOMAS B. NUTMAN, M.D., ERIC A. OTTESON, M.D.RICHARD T. DAVEY JR., M.D.Search for more papers by this author, THOMAS B. NUTMAN, M.D.Search for more papers by this author, ERIC A. OTTESON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-2-430_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the report by Farber and Laguarda (1) of their use of serologic diagnosis in a probable case of human pulmonary nodular disease due toDirofilaria immitis. We cannot, however, concur with their conclusion that the use of the enzyme-linked immunosorbent assay (ELISA) or other serologic assays "rather than invasive procedures, such as thoracotomy, may be indicated in similar clinical settings in geographic areas whereD. immitisinfestation is common." Such a conclusion is not supported by available seroepidemiologic data. In addition to the obvious problems with suboptimal sensitivity (2), the serodiagnosis...References1. FARBERLAGUARDA HR. Human pulmonary dirofilarial infection. [Letter]. Ann Intern Med. 1987;106:777-8. LinkGoogle Scholar2. AMBROISE-THOMASPEYRON PF. Filariasis. In: WALLS KW, SCHANTZ PM, eds. Immunodiagnosis of Parasitic Diseases. Orlando, Florida: Academic Press; 1986:233-53. Google Scholar3. GLICKMANGRIEVESCHANTZ LRP. Serologic diagnosis of zoo notic pulmonary dirofilariasis. Am J Med. 1986;80:161-4. CrossrefMedlineGoogle Scholar4. CIFERRI F. Human pulmonary dirofilariasis in the United States: a critical review. Am J Trop Med Hyg. 1982;31:302-8. CrossrefMedlineGoogle Scholar5. SCHERRSCHERR BG. HOW many humans have canine heartworm? Diagn Med. 1983;6:95-6. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByElusive migratory subcutaneous dirofilariasisDirofilariose pulmonar humana, adquirida no Brasil: comunicação de um casoPulmonary coin lesions caused byDirofilaria immitis 1 September 1987Volume 107, Issue 3Page: 430-431KeywordsEnzyme linked immunosorbent assayGeographic areasInfectious diseasesPulmonary diseasesSerodiagnosisThoracotomy Issue Published: 1 September 1987 PDF DownloadLoading ...
Request for Complementary Medicine After Brain Death
Authors: Laurence B. McCullough
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eating Problems and Related Weight Control Behaviour in Adult Japanese Women
Authors: Kazutoshi Nakamura, Yoshihiko Hoshino, Atsushi Watanabe, Kyoichi Honda, Shinichi Niwa, Masaharu Yamamoto
Journal: Psychotherapy and Psychosomatics (1999)

Fewer studies concerning eating problems have been conducted in adult than in adolescent female populations. The aims of this study are to ascertain the proportion of eating problems and clarify weight control behaviour in adult Japanese women.This study employed a questionnaire survey with a cross-sectional design. Subjects were adult females aged 20-39 years, working in a computer factory. Four hundred and six women agreed to participate in the study. The questionnaire elicited self-reported age, body height, body weight and various histories of dieting, fasting and purging behaviour. The Eating Attitudes Test 26-item version (EAT-26) was also administered. Subjects showing an EAT-26 score equal to or greater than 20 were identified as having eating problems.Among the subjects, 172 women (42.4%) had some history of dieting behaviour and 24 (5.9%) had some history of fasting behaviour. Regarding misuse of laxatives, diet pills and diuretics for the purpose of weight loss, 50 (14.3%) were past or current users of diet pills, followed by 42 (10.3%) laxative abusers and 15 (3.7%) diuretic abusers. Six (1.5%) subjects had an EAT-26 score of 20 or greater, 5 (1.9%) in their 20s, and 1 (0.8%) in her 30s, the difference not being statistically significant.Although dieting behaviour is common in adult Japanese working women, the proportion of eating problems is low in comparison with Western adult populations.
Functional Recovery and Orthopedic Management of Brachial Plexus Palsies
Authors: M. Mark Hoffer
Journal: JAMA (1981)

Functional recovery in 133 patients with brachial palsy is documented over a five-year period. Clinical examination is more reliable than electromyogram or myelogram for obtaining prognostic information. Erb's C V, VI palsies have improved function with cuff transfers and elbow flexor plasties. Posterior cord palsies often require extension plasties of the hand and glenohumeral fusions. C V, VI, VII palsies may require all of these procedures. Klumpke C VIII-T I palsies develop arm-trunk holding power. Adults with total palsies often complain of continued pain, which may be relieved by orthoses. (<i>JAMA</i>1981;246:2467-2470)
Influence of correction of flow limitation on continuous positive airway pressure efficiency in sleep apnoea/hypopnoea syndrome
Authors: JC Meurice, J Paquereau, A Denjean, F Patte, F Series
Journal: European Respiratory Journal (1998)

We evaluated the efficiency of two different treatment procedures with continuous positive airway pressure (CPAP) on sleep, nocturnal breathing characteristics and daytime vigilance in 18 newly diagnosed patients with untreated sleep apnoea/hypopnoea syndrome (SAHS) randomly allocated to two different groups. In group I, the positive pressure (PP) level was set to suppress flow limitation (PFL), while in group II the PP was set at a level that eliminated only apnoea/hypopnoea and snoring (PAHS). At the end of a 3 week period of home CPAP therapy, a follow-up sleep study, vigilance and cognitive tests were made. Overall, PFL was significantly higher than PAHS values (PFL: 10.42.6 cmH2O; PAHS: 8.9+/-2.6 cmH2O; p&lt;0.01, mean+/-SD). We found no difference in sleep quality, nocturnal saturation and apnoea/hypopnoea index, or in daytime vigilance tests between the two groups at the end of the treatment period. However, there was a significantly greater scattering in the changes of sleep latency in group II than in group I. This was associated with a significant difference in the daily duration of nasal CPAP use between the two groups (group I: 7.29+/-0.95 h x day(-1); group II: 6.01+/-0.94 h x day(-1); p=0.01) and with a positive correlation between final maintenance of wakefulness test values and the duration of CPAP use (p&lt;0.05; r=0.55). These results tend to show that correcting flow limitation is associated with a higher observance and a more important efficiency in normalizing daytime vigilance than with conventional nasal continuous positive airway pressure.
CORTICAL ALGORITHMS FOR PERCEPTUAL GROUPING
Authors: Pieter R. Roelfsema
Journal: Annual Review of Neuroscience (2006)

A fundamental task of vision is to group the image elements that belong to one object and to segregate them from other objects and the background. This review provides a conceptual framework of how perceptual grouping may be implemented in the visual cortex. According to this framework, two mechanisms are responsible for perceptual grouping: base-grouping and incremental grouping. Base-groupings are coded by single neurons tuned to multiple features, like the combination of a color and an orientation. They are computed rapidly because they reflect the selectivity of feedforward connections. However, not all conceivable feature combinations are coded by dedicated neurons. Therefore, a second, flexible form of grouping is required called incremental grouping. Incremental grouping enhances the responses of neurons coding features that are bound in perception, but it takes more time than does base-grouping because it relies also on horizontal and feedback connections. The modulation of neuronal response strength during incremental grouping has a correlate in psychology because attention is directed to those features that are labeled by the enhanced neuronal response.
Acute myeloid leukemia with T‐cell receptor gamma gene rearrangement occurring in a patient with chronic lymphocytic leukemia: A case report
Authors: Hassan A. Hatoum, Rami A.R. Mahfouz, Zaher K. Otrock, Abdel‐Rahman Hudaib, Ali T. Taher, Ali I. Shamseddine
Journal: American Journal of Hematology (2006)

Abstract The association of chronic lymphocytic leukemia (CLL) and acute leukemia, either lymphoid or myeloid is a rare event. Our review of the medical literature revealed only 6 cases of CLL transformation to acute myeloid leukemia (AML) (M0, M1 and M2) with no other associated malignancy. We report a similar case but with occurrence of AML‐M4 associated with normal cytogenetic analysis and molecular testing but with positive T‐cell receptor gamma gene rearrangement rather than the usual Vbeta rearrangement. Am. J. Hematol., 2006. © 2006 Wiley‐Liss, Inc.
Gene Silencing via RNAi and siRNA Quantification in Tumor Tissue Using MEND, a Liposomal siRNA Delivery System
Authors: Yu Sakurai, Hiroto Hatakeyama, Yusuke Sato, Mamoru Hyodo, Hidetaka Akita, Hideyoshi Harashima
Journal: Molecular Therapy (2013)

Small interfering RNA (siRNA) would be predicted to function as a cancer drug, but an efficient siRNA delivery system is required for clinical development. To address this issue, we developed a liposomal siRNA carrier, a multifunctional envelope-type nanodevice (MEND). We previously reported that a MEND composed of a pH-sensitive cationic lipid, YSK05, showed significant knockdown in both in vitro and in tumor tissue by intratumoral injection. Here, we report on the development of an in vivo siRNA delivery system that is delivered by systemic injection and an analysis of the pharmacokinetics of an intravenously administered siRNA molecule in tumor tissue. Tumor delivery of siRNA was quantified by means of stem-loop primer quantitative reverse transcriptase PCR (qRT-PCR) method. PEGylation of the YSK-MEND results in the increase in the accumulation of siRNA in tumor tissue from 0.0079% ID/g tumor to 1.9% ID/g tumor. The Administration of the MEND (3 mg siRNA/kg body weight) showed about a 50% reduction in the target gene mRNA and protein. Moreover, we verified the induction of RNA interference by 5′ RACE-PCR method. The collective results reported here indicate that an siRNA carrier was developed that can deliver siRNA to a target cell in tumor tissue through an improved siRNA bioavailability. Small interfering RNA (siRNA) would be predicted to function as a cancer drug, but an efficient siRNA delivery system is required for clinical development. To address this issue, we developed a liposomal siRNA carrier, a multifunctional envelope-type nanodevice (MEND). We previously reported that a MEND composed of a pH-sensitive cationic lipid, YSK05, showed significant knockdown in both in vitro and in tumor tissue by intratumoral injection. Here, we report on the development of an in vivo siRNA delivery system that is delivered by systemic injection and an analysis of the pharmacokinetics of an intravenously administered siRNA molecule in tumor tissue. Tumor delivery of siRNA was quantified by means of stem-loop primer quantitative reverse transcriptase PCR (qRT-PCR) method. PEGylation of the YSK-MEND results in the increase in the accumulation of siRNA in tumor tissue from 0.0079% ID/g tumor to 1.9% ID/g tumor. The Administration of the MEND (3 mg siRNA/kg body weight) showed about a 50% reduction in the target gene mRNA and protein. Moreover, we verified the induction of RNA interference by 5′ RACE-PCR method. The collective results reported here indicate that an siRNA carrier was developed that can deliver siRNA to a target cell in tumor tissue through an improved siRNA bioavailability.
A GROUP OF MICROORGANISMS TRANSMITTED HEREDITARILY IN TICKS AND APPARENTLY UNASSOCIATED WITH DISEASE
Authors: E. V. Cowdry
Journal: The Journal of Experimental Medicine (1925)

1. Pleomorphic, bacterium-like, Gram-negative, intracellular microorganisms, which stained much less intensely with ordinary dyes than most bacteria were found in sixteen species of ticks comprising examples of the Argasidae and the Ixodidae. 2. In six of these species studied intensively slight differences in the microorganisms were detected, sufficient to permit identification of the vectors by microscopic examination of the microorganism alone. 3. No evidence was seen of injury to the tissues of the arachnid hosts of the microorganisms other than that incident to mechanical distention of the cells containing them. 4. The detection of the microorganisms in the eggs of ten species, in the unfed larvae of eight species, and at nearly related stages throughout the life cycle of three others leads to the conclusion that they are transmitted hereditarily.
Synthesis of intrathecal interferon in systemic lupus erythematosus with neurological complications.
Authors: P Lebon, G R Lenoir, A Fischer, A Lagrue
Journal: BMJ (1983)

Intrathecal synthesis of interferon in the absence of viral or bacterial infection was detected during the occurrence of neurological complications in two patients with systemic lupus erythematosus. The interferons displayed characteristics similar to those observed in the sera of patients with the disease. No interferon inducing activity was detected in the cerebrospinal fluid or serum of the two patients. These observations support the hypothesis of a localised mechanism of interferon induction in systemic lupus erythematosus which includes the interaction of lymphocytes with damaged tissues.
ABC of Work Related Disorders: Occupational Dermititis
Authors: I. R White
Journal: BMJ (1996)

Sheeted eczema over dorsal aspect of hand and up forearm due to allergic contact dermatitis to a carbamate accelerator in protective rubber gloves. PathogensDermatitis may be endogenous or exogenous, or a combination of these, and may be aggravated by pathogens.* Dermatitis first occurred while employed * There is a history of aggravation by work * There may be, at least initially, improvement (or clearance) when not at work * There is exposure to irritant factors or potential allergens * Work is in an "at risk" occupation Examples of common irritants * "Wet work" * Soluble coolants * Solvents * Vegetable juices * Detergents * Wet cement With all of above, skin may be "hit" at several target sites, causing damage by several mechanisms ...
Hepataitis C compensation case could open floodgate to claims
Authors: C. Kovac
Journal: BMJ (2002)

A man who claimed he was infected with hepatitis C as the result of a transfusion of unscreened blood administered during a hospital operation in 1993 has won a lawsuit against the Hungarian government.

The patient, who requested anonymity, was awarded 3three million forints ($10, 700; £7,600; €12, 000) in compensation and 15, 000 forints ($54; £38; €8862) in monthly benefits.

The decision by …