Immunoglobulins and Complement in Skin in Graft-Versus-Host Disease
Authors: Susanne Ullman, Richard L. Spielvogel, John H. Kersey, Robert W. Goltz
Journal: Annals of Internal Medicine (1976)

Letters1 August 1976Immunoglobulins and Complement in Skin in Graft-Versus-Host DiseaseSUSANNE ULLMAN, M.D., RICHARD L. SPIELVOGEL, M.D., JOHN H. KERSEY, M.D., ROBERT W. GOLTZ, M.D.SUSANNE ULLMAN, M.D.Search for more papers by this author, RICHARD L. SPIELVOGEL, M.D.Search for more papers by this author, JOHN H. KERSEY, M.D.Search for more papers by this author, ROBERT W. GOLTZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-2-205_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGraft-versus-host disease is a frequent complication after bone marrow transplantation. In this entity, histoincompatible donor lymphocytes may become aggressive and produce cellular damage responsible for the classic findings of disturbances of the skin, hepatocellular, and gastrointestinal tissue (1-3). Graft-versus-host disease may be either acute or chronic. Skin lesions that develop in patients undergoing bone marrow transplantation may be caused by cell-mediated mechanism. However, humoral antibodies may also be of pathogenetic importance (4). The skin lesions are often difficult to distinguish histopathologically from other skin conditions. Patients frequently receive high-dose chemotherapy and radiotherapy and multiple, potentially sensitizing drugs including antibiotics, and...References1. GATTIKERSEYYUNIS RJE: Graft-versus-host disease. Prog Clin Pathol 5:1-18, 1973 MedlineGoogle Scholar2. THOMASSTORBCLIFT ERR: Bone-marrow transplantation (second of two parts). N Engl J Med 292:895-902, 1975 CrossrefMedlineGoogle Scholar3. KERSEYMEUWISSENGOOD JHR: Graft versus host reactions following transplantation of allogeneic hematopoietic cells. Hum Pathol 2:389-402, 1971 CrossrefMedlineGoogle Scholar4. MERRITTMANNROGENTINE CDG: Cytotoxic antibody for epithelial cells in human graft versus host disease. Nature 232:638-639, 1971 CrossrefMedlineGoogle Scholar5. ULLMANHALBERGWOLF-JÜRGENSEN SPP: Deposits of immunoglobulins and complement C3 in clinically normal skin of patients with lupus erythematosus. Acta Derm Venereol (Stockh) 55:109-112, 1975 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byERYTHRODERMAGraft-versus-host reactions in dermatologyImmunology and Immunopathology of the Intestines: Experimental Immune Complex Disease of the IntestineComplement and Complement ReactionsCutaneous ImmunofluorescenceHuman Cutaneous Graft-Versus-Host-DiseaseMurine Graft-Versus-Host Skin Disease: A Chronologic and Quantitative Analysis of Two Histologic PatternsSyndrome Resembling Graft-Versus-Host Disease in a Patient with Disseminated Carcinoma 1Immunologic studies of skin biopsy specimens in connective tissue diseasesLupus Band TestGRAFT VERSUS HOST REACTIONUltrastructural Findings in Acute and Chronic Graft-Vs-Host Reaction of the Skin*The Biology and Detection of Immune ComplexesCutaneous immunopathologyGraft versus host disease: Pathogenesis, recognition, prevention and treatment 1 August 1976Volume 85, Issue 2Page: 205-205KeywordsAntibioticsAntibodiesBone marrow transplantationDrugsHigh-dose chemotherapyLesionsLymphocytesPathogensSkin diseases Issue Published: 1 August 1976 PDF downloadLoading ...