tbuckley/cabot-search huggingface dataset:
Abstract A56: Bone morphogenetic protein antagonist DMH1 inhibits metastasis in a mouse model of breast cancer
Authors: Philip Owens, Michael W. Pickup, Agnieszka E. Gorska, Sergey V. Novitskiy, Charles C. Hong, Harold L. Moses
Journal: Cancer Research (2013)

Abstract Bone Morphogenetic Proteins (BMPs) are secreted cytokines/growth factors belonging to the Transforming Growth Factor β (TGFβ) superfamily. BMPs have recently been shown to be overexpressed in human breast cancers; however, loss of BMP signaling in mammary carcinomas has also been shown to accelerate metastases. Human breast cancers display active BMP signaling by phosphorylated Smads 1, 5 and 8 in both the tumor and the stromal microenvironment. We hypothesized that inhibiting BMP signaling in both the tumor epithelium as well as the surrounding microenvironment would prevent tumor progression. To test this hypothesis we used DMH1, which is a selective and specific antagonist of the type I BMP receptor. Mice that express the MMTV.PyVmT oncogene were either treated with DMSO vehicle or DMH1 for six weeks following initial mammary tumor palpation. Following six weeks, animals were euthanatized and evaluated for lung metastases. Whole mount staining of lungs revealed a statically significant reduction in lung metastasis in DMH1 treated animals compared to vehicle treated (p-value = 0.03). Primary tumors demonstrated reduced proliferation (BrdU incorporation) and increased apoptosis (cleaved-caspase-3) when treated with DMH1. RNA isolated from peripheral blood at the time of sacrifice indicated decreased circulating tumor cells measured by real-time PCR. Overall, the BMP pathway represents an understudied pathway that may be suitable for targeted therapy in breast cancer. Citation Format: Philip Owens, Michael W. Pickup, Agnieszka E. Gorska, Sergey V. Novitskiy, Charles C. Hong, Harold L. Moses. Bone morphogenetic protein antagonist DMH1 inhibits metastasis in a mouse model of breast cancer. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr A56.
Book Review Emergency Medicine Edited by John M. Howell, with Michael Altieri, Andy S. Jagoda, John E. Prescott, James L. Scott, and Thomas O. Stair. Philadelphia, W.B. Saunders, 1998. $195. 1735 pp. in two volumes, illustrated. 0-7216-5825-3
Authors: Richard C. Dart, Luke Yip
Journal: New England Journal of Medicine (1998)
Review of environmental factors affecting hearing.
Authors: J H Mills, J A Going
Journal: Environmental Health Perspectives (1982)

The major nongenetic causes of sensorineural hearing loss are exposure to noise, aging, ototoxic drugs, viral and bacterial infections, and interactions between these factors. Regarding exposure to continuous noise, the data base from laboratory and field studies indicates that a risk of hearing loss is present when noise levels exceed 75-80 dBA. As noise level, duration and number of exposures increase so does risk. The data base for other forms of noise (intermittent, impact) is not as established. Risk of hearing loss due to impulse noise increases as the peak SPL exceeds 145-155 dB and as the duration of the impulse, the number of impulses and the number of exposures increase. High-level acoustic impulses can cause severe, permanent hearing loss. Interaction between some steady-state noises and some acoustic impulses can be synergistic, producing extensive injuries to the organ of Corti. Noise can also interact synergistically with some aminoglycoside antibiotics to produce severe injuries in the inner ear. These antibiotics are also capable of producing hearing loss and indeed may do so in up to 55% of the one million persons who receive aminoglycoside antibiotics during the course of treatment for tuberculosis or severe gram-negative infections. Bacterial and viral infections may also produce mild to severe hearing loss. With the development of rubella vaccine and Rhogam, cytomegalovirus may have become the most common cause of congenital deafness. Aging is also a major cause of hearing loss. Exposure to occupational and environmental noise, certain diseases and life styles (diet, stress, drugs) may interact with the specific effects of aging. The result is moderate to severe hearing loss in a majority of older persons.
Tumor angiogenesis imaged by optical tomography can accurately diagnose early-stage invasive breast cancers.
Authors: Q Zhu, M Kane, S Tannenbaum, E Cronin, P Hegde, M Iyers, P DeFusco, Y Ardeshirpour, C Xu, N Baccaro, S Kurtzman, P Deckers
Journal: Cancer Research (2009)

Abstract Abstract #52 Background: Our initial clinical results obtained from a novel ultrasound(US)-guided diffusive-wave optical tomography have shown that early-stage invasive breast cancers may be distinguished from benign lesions with an average of two-fold angiogenesis contrast. However, breast cancer is a heterogeneous disease with different growth and metabolic rates that result in a wide range of functional differences. In this report, we present a spectrum of breast lesion angiogenesis distributions from benign lesions, early-stage invasive cancers to advanced cancers. The objective is to investigate the feasibility of optical tomography with US localization in differentiating malignant from benign breast masses.&amp;#x2028; Materials and Methods: 123 patients underwent US-guided biopsy and were imaged with a combined imager consisting of a commercially available US system and a near infrared (NIR) imager. A hand-held probe with a centrally located US transducer and NIR sensors surrounding it was used to simultaneously acquire co-registered US images and optical data. The lesion location provided by US was used to guide optical imaging reconstruction. Light absorption was measured at multiple wavelengths. From this, tumor angiogenesis was assessed based on calculated total hemoglobin concentration.&amp;#x2028; Results: There were 23 stage I carcinomas, 21 stage II to IIII carcinomas, and 112 benign lesions. The mean maximum and average values of total hemoglobin concentration (tHb) of the stage I malignant group were 102.0 μ mol/liter (±30.7) and 72.3 μ mol/liter ( ±18.1), and the values of the state II to IIII malignant group were 114.4 μ mol/liter (±38.4) and 75.4 μ mol/liter (±25.2), respectively. The mean maximum and average values of the benign group were 54.0 μ mol/liter (±22.3) and 38.2 μ mol/liter (±14.8), respectively. Both maximum and average of tHb level were statistically significantly higher in the malignant groups than the benign group (P&amp;lt;0.01). An example of a six mm stage I cancer imaged by US (Fig.1(a)) and the NIR imager (Fig.1(b) is given in Figure 1.&amp;#x2028; &amp;#x2028; The detection sensitivity and specificity of the stage I cancer group were 91% and 94%, and 76% and 94% for the stage II to IIII cancer group.&amp;#x2028; Discussion: The tumor angiogenesis distributions are complex and the angiogenesis contrast holds great promise for distinguishing early-stage invasive breast cancers from benign lesions. For advanced cancers, the angiogenesis distribution is heterogeneous and often presents periphery enhancement and/or shadow effect which can be used to assist US diagnosis. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 52.
Few reprint requests come from less privileged countries
Authors: N. P Burrows
Journal: BMJ (1996)

improved haemostasis.Use of predeposited auto- logous blood, intraoperative autotransfusion, and haemodilution are not readily adaptable to neonates having extensive surgery, although they may be appropriate for older children.2After our success in resecting a large sacrococcygeal teratoma with minimal blood loss when we used aprotinin in the child of Jehovah's Wit-nesses3 we have observed both subjective and objective reductions in blood loss and transfusion requirements in neonates having surgery for sacrococcygeal teratoma, necrotising enterocolitis, and massive cervical cystic hygroma when we used a bolus of aprotinin (10000 kIU/kg (=1 ml/kg)) on induction of anaesthesia followed by an infusion at 1 ml/kg/h during the operative period.Our only other experience in the perioperative use of desmopressin is in patients with von Willebrand's disease.We suggest that further evaluation of the use of aprotinin perioperatively may obviate the need for expensive recombinant erythropoietin to treat postoperative anaemia.The legal recourse available when transfusion is necessary deserves clarification.While the courts may uphold the decision of an adult Jehovah's Witness to refuse transfusion, parents would be charged with neglect for failing to seek, or permit, desirable medical treatment for their children, even if that treatment were to contravene religious doctrine.Parental refusal of transfusion does not necessarily necessitate making the child a ward of court and thereby removing all parental authority as in most cases this is a conflict of interest between religious beliefs and the wellbeing of the child.Parents may be absolved of this particular respon- sibility by a specific issue order, which gives legal sanction to only the action identified, such as the administration of blood.A specific issue order is made under the private law provisions of the 1989 Children Act, and the High Court is approached direct.
Quantitative assessment of blood flow, blood volume and blood oxygenation effects in functional magnetic resonance imaging
Authors: Peter C.M. van Zijl, Scott M. Eleff, John A. Ulatowski, Joni M.E. Oja, Aziz M. Uluǧ, Richard J. Traystman, Risto A. Kauppinen
Journal: Nature Medicine (1998)
Predictors and consequences of unemployment among construction workers: prospective cohort study
Authors: P. Leino-Arjas, J. Liira, P. Mutanen, A. Malmivaara, E. Matikainen
Journal: BMJ (1999)

<h3>Abstract</h3> <b>Objective:</b> To study predictors and consequences of unemployment. <b>Design:</b> Prospective cohort study. <b>Setting:</b> 11 construction companies in southern Finland. <b>Participants:</b> 586 male employees, aged 40-59 years at baseline in 1991 and not retired during a 4 year follow up. <b>Main outcome measures:</b> Long term unemployment, stress symptoms, disease, alcohol consumption, exercise activity, and body mass index. <b>Results:</b> In a multiple logistic regression model, long term unemployment (&gt;24 months <i>v</i> ≤24 months) was predicted by age 50-54 years <i>v</i> 40-44 years (odds ratio 2.0, 95% confidence interval 1.1 to 3.7), ≤3 years9 employment in the present job (3.1, 1.9 to 5.1), previous unemployment (2.1, 1.2 to 3.8), being single (1.8, 1.1 to 3.1), current smoking (2.6, 1.4 to 4.7), high alcohol consumption (2.1, 1.1 to 4.3), body mass index &lt;23 kg/m<sup>2</sup><i>v</i> 23-29 kg/m<sup>2</sup> (2.4, 1.3 to 4.4), frequent stress symptoms (2.0, 1.2 to 3.2), mental disorders (7.8, 1.5 to 40.0), and skin diseases (2.0, 1.0 to 3.9). Workers who were unemployed long term reported increased stress (2.1, 1.2 to 3.5) but fewer incident diseases (0.6, 0.4 to 0.9), decreased alcohol consumption (2.9, 1.6 to 5.2), increased exercise (1.9, 1.2 to 3.0), and increased body mass index (2.3, 1.3 to 4.0) compared with the rest of the cohort. <b>Conclusions:</b> The workers9 perceptions of work did not predict unemployment. Health based selection to long term unemployment was shown. Smoking and high alcohol consumption predated unemployment, but favourable lifestyle changes were observed among the unemployed workers. Stress predicted unemployment, which further increased the stress. <h3>Key messages</h3> Among middle aged construction workers, long term unemployment was predicted by an unstable occupational history, health problems, smoking, high alcohol consumption, low body mass index, and being single Stress predicted long term unemployment, which further increased the level of stress Men unemployed long term reported increased exercise and decreased alcohol consumption, but increased body mass index, and fewer incident diseases than the rest of the cohort Changes in personal economic situation with unemployment mediated the effect of unemployment on stress but not on alcohol consumption
Occupational skin disease in the construction industry
Authors: M. Bock, A. Schmidt, T. Bruckner, T.L. Diepgen
Journal: British Journal of Dermatology (2003)

Journal Article Occupational skin disease in the construction industry Get access M. Bock, M. Bock Department of Clinical Social Medicine, Centre of Occupational and Environmental Dermatology, University of Heidelberg, Thibautstr. 3, D‐69115 Heidelberg, Germany *Consultant in Occupational Dermatology, Juvenellestr. 45, D‐90419 Nuremberg, Germany Search for other works by this author on: Oxford Academic Google Scholar A. Schmidt, A. Schmidt Department of Clinical Social Medicine, Centre of Occupational and Environmental Dermatology, University of Heidelberg, Thibautstr. 3, D‐69115 Heidelberg, Germany *Consultant in Occupational Dermatology, Juvenellestr. 45, D‐90419 Nuremberg, Germany Search for other works by this author on: Oxford Academic Google Scholar T. Bruckner, T. Bruckner Department of Clinical Social Medicine, Centre of Occupational and Environmental Dermatology, University of Heidelberg, Thibautstr. 3, D‐69115 Heidelberg, Germany *Consultant in Occupational Dermatology, Juvenellestr. 45, D‐90419 Nuremberg, Germany Search for other works by this author on: Oxford Academic Google Scholar T.L. Diepgen T.L. Diepgen Department of Clinical Social Medicine, Centre of Occupational and Environmental Dermatology, University of Heidelberg, Thibautstr. 3, D‐69115 Heidelberg, Germany *Consultant in Occupational Dermatology, Juvenellestr. 45, D‐90419 Nuremberg, Germany Thomas L. Diepgen. E‐mail: Thomas_Diepgen@med.uni‐heidelberg.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 6, 1 December 2003, Pages 1165–1171, https://doi.org/10.1111/j.1365-2133.2003.05748.x Published: 01 December 2003 Article history Accepted: 30 April 2003 Published: 01 December 2003
Alterations in diastolic ventricular interdependence due to myocardial infarction
Authors: W. P SANTAMORE, L. PAPA
Journal: Cardiovascular Research (1988)

Journal Article Alterations in diastolic ventricular interdependence due to myocardial infarction Get access WILLIAM P SANTAMORE, WILLIAM P SANTAMORE Search for other works by this author on: Oxford Academic PubMed Google Scholar LOUIS PAPA LOUIS PAPA **From the Section on Cardiology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina; and *the Cardiology Section, University of Medicine & Dentistry of New Jersey, Schoolof Osteopathic Medicine, Camden, New Jersey Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 22, Issue 10, October 1988, Pages 726–731, https://doi.org/10.1093/cvr/22.10.726 Published: 01 October 1988 Article history Received: 15 December 1987 Accepted: 30 May 1988 Published: 01 October 1988
Clinical and Anatomic Features in Five Hundred Patients with Fatal Acute Myocardial Infarction
Authors: KYU TAIK LEE, WILBUR A. THOMAS, ERWIN R. RABIN, R. M. O'NEAL
Journal: Circulation (1957)

An autopsy series of 500 patients who died with anatomic evidence of acute Invocardial infarction is reviewed. The incidence of various clinical and anatomic features is presented. The clinical and anatomic features of patients who died from the first attack of myocardial infarction is compared with those of patients dying after repeated attacks. Similarly, various other features were studied, such as the time that clapsed between the onset of symptoms and death and also the presence or absence of old myocardial infarcts.
Expression of angiotensinogen in proximal tubule as a function of glomerular filtration rate
Authors: Barbu Gociman, Andreas Rohrwasser, Pierre Lantelme, Tong Cheng, Grant Hunter, Smith Monson, Jennifer Hunter, Elaine Hillas, Paul Lott, Tomoaki Ishigami, J.M. Lalouel
Journal: Kidney International (2004)
Migration Associated with Climate Change: Modern Face of an Ancient Phenomenon
Authors: Julia R. Barrett
Journal: Environmental Health Perspectives (2012)

Adverse respiratory effects and short-term hospital admissions have been linked to acute exposure to fine particulate matter (PM 2.5 ), but few studies have examined mortality risks associated with chronic exposure.Now, in Canada's first national-level cohort study of the subject, investigators report an association between cardiovascular mortality and long-term exposure to PM 2.5 [EHP 120(5):708-714; Crouse et al.].Most research examining associations between ambient air pollution and human health has used data generated by ground-based air-pollution monitors over short periods of time.But in the current study, researchers also calculated long-term exposure levels using satellite-based estimates of ground-level PM 2.5 .Study subjects consisted of 2.1 million adults who were included in the 1991-2001 Canadian census mortality follow-up study.For residents of cities with ground-based air monitors, the investigators calculated average mean annual concentrations of PM 2.5 for the period 1987-2001 and assigned exposure levels to individuals based on their residence during that time.They also calculated exposure estimates for the whole cohort for the period 2001-2006 based on satellite remote sensing observations.
THE AGGLUTINATING PROPERTIES OF EXUDATES FROM PATIENTS WITH RHEUMATIC FEVER
Authors: Charles H. Hitchcock, Homer F. Swift
Journal: Journal of Clinical Investigation (1933)

Recent reports (1, 2, 3) that serum from febrile patients and exudates from tuberculous pleurae exert an apparently non-specific agglutinating effect upon certain gram-positive cocci have prompted the publication of similar results concerning the properties of exudates obtained from patients suffering from various acute manifestations of rheumatic fever.During the course of a search for agglutinins and precipitins in the body fluids of such patients, it was observed that exudate obtained from the knee during the course of an acute arthritis possessed a marked capacity to cause flocculent growth (thread reaction) of a certain strain of Streptococcus haemalyticus.This strain, " S43 matt avirulent," had been kept in the lab- oratory for many years upon artificial media.So striking was this effect, noted at times even in a dilution of 1: 10,000 of the exudate, that it seemed desirable to extend the observations to other organisms, as well as to include exudates from conditions other than rheumatic fever.
Positive Cancer Smears in Teenage Girls—A Warning
Authors: Bernard Seligman
Journal: JAMA (1962)

<h3>To the Editor:—</h3> The lead article in the Oct. 28, 1961, issue ofThe Journal(Ferguson, J. H.:<b>178</b>:365) is an example of ingenuity and deductions that belong to a research journal. Busy physicians readingThe Journalof the American Medical Association will accept the words of our journal as gospel. The statement is made that "the preinvasive lesion which can produce a positive cancer smear has a permanent cure rate of 100%." This is yet to be proven. Many of these cases desquamate and do not become invasive. These have a 100% chance of cure. As far as surgical intervention is concerned, it remains to be proven that cancer<i>in situ</i>becomes invasive, and if it does that the treated patient with an invasive type of cancer will live significantly longer and have a more useful life. Cancer<i>in situ</i>is still a field beclouded with uncertainties in
Early transjugular intrahepatic portosystemic shunt in patients with cirrhosis and variceal bleeding
Authors: Martin Rössle, Daniel Grandt
Journal: Hepatology (2010)

Abstract Background: Patients with cirrhosis in Child–Pugh class C or those in class B who have persistent bleeding at endoscopy are at high risk for treatment failure and a poor prognosis, even if they have undergone rescue treatment with a transjugular intrahepatic portosystemic shunt (TIPS). This study evaluated the earlier use of TIPS in such patients. Methods: We randomly assigned, within 24 hours after admission, a total of 63 patients with cirrhosis and acute variceal bleeding who had been treated with vasoactive drugs plus endoscopic therapy to treatment with a polytetrafluoroethylene-covered stent within 72 hours after randomization (early-TIPS group, 32 patients) or continuation of vasoactive-drug therapy, followed after 3 to 5 days by treatment with propranolol or nadolol and long-term endoscopic band ligation (EBL), with insertion of a TIPS if needed as rescue therapy (pharmacotherapy–EBL group, 31 patients). Results: During a median follow-up of 16 months, rebleeding or failure to control bleeding occurred in 14 patients in the pharmacotherapy–EBL group as compared with 1 patient in the early-TIPS group (P=0.001). The 1-year actuarial probability of remaining free of this composite end point was 50% in the pharmacotherapy–EBL group versus 97% in the early-TIPS group (P&lt;0.001). Sixteen patients died (12 in the pharmacotherapy–EBL group and 4 in the early-TIPS group, P=0.01). The 1-year actuarial survival was 61% in the pharmacotherapy–EBL group versus 86% in the early-TIPS group (P&lt;0.001). Seven patients in the pharmacotherapy–EBL group received TIPS as rescue therapy, but four died. The number of days in the intensive care unit and the percentage of time in the hospital during follow-up were significantly higher in the pharmacotherapy–EBL group than in the early-TIPS group. No significant differences were observed between the two treatment groups with respect to serious adverse events. Conclusions: In these patients with cirrhosis who were hospitalized for acute variceal bleeding and at high risk for treatment failure, the early use of TIPS was associated with significant reductions in treatment failure and in mortality. (Current Controlled Trials number, ISRCTN58150114.)
Doctors must put needs of child before relationship with parents, judge rules
Authors: C. Dyer
Journal: BMJ (2012)

A girl with asthma spent years undergoing unnecessary, harmful, and potentially lethal treatment because doctors trusted her parents too much, a High Court judge in London has found. Her condition immediately improved when she was removed from her family.

In what could come to be seen as a landmark judgment, the judge said, “The preservation of a working relationship with parents cannot take precedence over the interests of a child.”

The 9 year old, referred to only as “J,” was admitted to hospital more than 50 times between 2005 and 2011, once for a three month stay, and 22 times by ambulance at night. She was subjected to multiple treatments, four of them unlicensed for children, including methotrexate, which can cause renal and liver damage and suppression of bone marrow.

Ever since she was under 12 months old “she had been under continuous medical care, and her condition had baffled and defeated …
Managing Noncompliance in the ‘Difficult’ Medical Patient: The Contributions of Insight
Authors: Antoinette Ambrosino Wyszynski
Journal: Psychotherapy and Psychosomatics (1990)

Psychodynamics can interfere with medical compliance, especially in psychologically vulnerable patients. A case is presented of a cancer patient who developed a powerful transference reaction to her oncologist, jeopardizing her treatment for cancer. Strategies for integrating techniques of insight-oriented psychotherapy with those of supportive psychotherapy are discussed in managing such reactions and improving compliance.
Recurrent typhoid in an HTLV-III antibody positive man.
Authors: D R Jarrett, R Zeegen
Journal: Gut (1986)

A case of recurrent typhoid fever in a homosexual man with antibodies to human T-cell lymphotropic virus-III (HTLV-III) and impaired cell mediated immunity is reported: we believe the first report of Salmonella typhi infection in association with HTLV-III disease.
Peculiar Intracytoplasmic Basophilic Bodies in Papillary Thyroid Carcinoma
Authors: Tetsuo Kondo, Kaori Kameyama, Tadao Nakazawa, Toshimichi Fujisawa, Eiji Sasaki, Megumi Tamura, Tomonori Kawasaki, Nobuki Nakamura, Tetsu Yamane, Koichi Ito, Ryohei Katoh
Journal: Endocrine Pathology (2009)