tbuckley/cabot-search huggingface dataset:
Cloning and expression of a mutant methylmalonyl coenzyme A mutase with altered cobalamin affinity that causes mut- methylmalonic aciduria.
Authors: A M Crane, R Jansen, E R Andrews, F D Ledley
Journal: Journal of Clinical Investigation (1992)

Distinct genotypic and phenotypic forms of methylmalonyl CoA mutase (MCM) apoenzyme deficiency can be delineated by biochemical analysis of mutant fibroblasts. One form, designated mut-, expresses a phenotype in which residual enzyme activity is evident in cultured cells exposed to high concentrations of hydroxycobalamin. We describe cloning of an MCM cDNA from cells exhibiting a mut- phenotype and characterization of the mutant gene product overexpressed in primary muto human fibroblasts and Saccharomyces cerevisiae. Three novel base changes were observed. Recombinant clones containing one of these base changes (G717V) express four characteristics of the mut- phenotype: failure to constitute [14C]propionate incorporation activity in fibroblasts assayed under basal cell culture conditions, constitution of [14C]propionate incorporation activity in fibroblasts stimulated with 0.1-1.0 micrograms/ml hydroxycobalamin, interallelic complementation with alleles bearing an R93H mutation, and an apparent Km (adenosylcobalamin) 1,000-fold higher than normal. These results demonstrate that the G717V mutation produces the mut- phenotype and localizes determinants for adenosylcobalamin binding near the carboxyl terminus of MCM.
Warning—Fraudulent Magazine Agent.
Authors: F. N. C. Jerauld
Journal: JAMA (1905)

Niagara Falls, N. Y., Sept. 26, 1905. <h3>To the Editor:</h3> —I would like to warn physicians throughThe Journalof a man by the name of Charles Croft, who pretends to be an agent for the World's Clubbing and Subscription Co., of New York City. Mr. Croft's method is to offer several magazines at an exceedingly low price so that nearly every man that he approached in this city bought magazines of him. He sold me<i>McClure's</i>, the<i>Cosmopolitan, Everybody's</i>and the<i>Black Cat</i>for $2.00 a year. Mr. Croft is a man about 26 years of age, would weigh about 165 pounds, smooth face, light brown hair, is well dressed and has a very pleasing manner. I have communicated with the publishers of the magazines which he sold me and they inform me that no subscription has been received and that Mr. Croft is a swindler.
Prevention of renal function worsening after percutaneous coronary interventions by hemofiltration in patients at high risk for contrast nephropathy
Authors: Giancarlo Marenzi, Gianfranco Lauri, Emilio Assanelli, Marco Grazi, Jeness Campodonico, Ivana Marana, Daniela Trabattoni, Antonio L. Bartorelli
Journal: Journal of the American College of Cardiology (2002)
FACTORS RESPONSIBLE FOR REDUCTION OF MORTALITY AND MORBIDITY IN PROSTATECTOMY
Authors: B. A. THOMAS
Journal: JAMA (1924)

During the years preceding the World War, I was strangely impressed by the fact that there were two schools of prostatectomists. One contended that the only proper way to remove the gland was suprapubically; the other insisted that the perineal was the exclusive route, and practically refused to employ the suprapubic method. It seemed to me that the attitude of each was rather dictatorial, bigoted and obviously wrong, that the patient was not always accorded a square deal, and that both would reap better results and reduce to a lower level their already admirable low mortality rates by recourse to the impartial employment of both methods and more exact discrimination as to the particular route to be adopted in each case. In other words, the surgeon should be qualified and prepared to perform the particular operation indicated by the pathologic condition presented; not, dogmatically, to subject the patient to any
Anti-IL-5 (Mepolizumab) reduces the expression of tenascin, procollagen III and lumican in the reticular basement membrane of human atopic asthmatics
Authors: S. Phipps, P. Flood-Page, A. Menzies-Gow, A. Wangoo, N. Barnes, J. Barkans, D. Robinson, A.B. Kay
Journal: Journal of Allergy and Clinical Immunology (2003)
Can We Predict Future Acute Coronary Events in Patients With Stable Coronary Artery Disease?
Authors: John A. Ambrose
Journal: JAMA (1997)

Many therapeutic measures have been developed to effectively treat patients with coronary disease. While secondary prevention has become a vital component in maximizing reductions in coronary disease mortality, subsequent acute coronary events still occur and are often unexpected and unpredictable. See also P 325. We now recognize several standard risk factors for the development of coronary disease and a modulation of some of these risk factors has been shown to decrease the incidence and recurrence of coronary events.<sup>1-3</sup>With the help of noninvasive and invasive cardiologic technology, we may also stratify coronary patients into low- and high-risk subgroups.<sup>4</sup>Mortality in coronary disease is directly related to the number of diseased vessels, the presence of left ventricular dysfunction, and an ischemic response on treadmill exercise testing, particularly when it occurs during the early stages of exercise. However, as stratification in prognosis is not all or none (ie, only some
Concordance between colonic myoelectrical signals recorded with intramuscular electrodes in the human rectosigmoid in vivo.
Authors: E A Wegman, S C Gandevia, A M Aniss
Journal: Gut (1990)

The myoelectrical activity of the human rectosigmoid colon was studied simultaneously in six subjects at two sites using two pairs of fine wire bipolar electrodes. The electrodes were spaced 2-5 cm apart in the rectosigmoid after insertion into the smooth muscle layers under direct vision at sigmoidoscopy. The electrodes were implanted at positions between 8 and 25 cm from the anal verge in different subjects. The frequency of myoelectrical burst activity together with the burst duration recorded by each electrode pair was examined. The relation of burst frequency and burst duration in the higher and lower placed electrodes was also assessed. In none of the subjects was three evidence of synchrony between the electrode pairs. In addition, there was no relation between the relative position of the electrodes and the intrinsic frequency of duration of myoelectrical bursts. It is concluded that regions of smooth muscle in the unstimulated human colon in vivo act independently and that there is no effective common neuromuscular drive under these conditions.
Treatment of Acute Bronchiolitis
Authors: Mary Ellen B. Wohl, Victor Chernick
Journal: New England Journal of Medicine (2003)

In this issue of the Journal, Wainwright et al.1 provide data from a clinical trial in which 194 infants hospitalized with bronchiolitis were treated with inhaled epinephrine or placebo. In this age of commercial support for clinical trials, funding is available only when commercial sponsors stand to make a profit from the manufacture of a drug. Thus, Wainwright et al. are to be congratulated for having tackled an important question using a multicenter, randomized, blinded clinical trial that does not involve a new drug. The authors' findings overturn the popular notion that treatment of bronchiolitis with inhaled epinephrine, as compared . . .
Acquired genomic copy number aberrations and survival in adult acute myelogenous leukemia
Authors: Brian Parkin, Harry Erba, Peter Ouillette, Diane Roulston, Anjali Purkayastha, Judith Karp, Moshe Talpaz, Lisa Kujawski, Sajid Shakhan, Cheng Li, Kerby Shedden, Sami N. Malek
Journal: Blood (2010)
Applying Intelligent Computing Techniques to Modeling Biological Networks from Expression Data
Authors: Wei-Po Lee, Kung-Cheng Yang
Journal: Genomics Proteomics & Bioinformatics (2008)

Abstract Constructing biological networks is one of the most important issues in systems biology. However, constructing a network from data manually takes a considerable large amount of time, therefore an automated procedure is advocated. To automate the procedure of network construction, in this work we use two intelligent computing techniques, genetic programming and neural computation, to infer two kinds of network models that use continuous variables. To verify the presented approaches, experiments have been conducted and the preliminary results show that both approaches can be used to infer networks successfully.
Abstract 1304: Cyclin D:Cdk4/6 activates RB by mono-phosphorylation during early G1 phase
Authors: Steven F. Dowdy, Manuel Kaulich
Journal: Cancer Research (2014)

Abstract The retinoblastoma tumor suppressor protein (Rb) functions to transcriptionally regulate multiple critical cellular activities, including early G1 phase, the DNA damage response, cell cycle exit and differentiation, but is infrequently mutated or deleted in cancer. To account for the lack of Rb mutations, a large body of work over the last 20+ years has led to a widely accepted model of G1 cell cycle progression that proposes cyclin D:Cdk4/6 complexes partially inactivate Rb during early G1 phase by progressive multi-phosphorylation, termed hypo-phosphorylation, on 15 Cdk sites resulting in release of E2F transcription factors that drive cells across the late G1 phase checkpoint and ultimately undergo cellular division. Surprisingly given the importance of G1 cell cycle progression in cancer, the core tenet of the model, namely cyclin D:Cdk4/6 inactivation of Rb by progressive multi-phosphorylation, remains largely unproven biochemically. Consequently, it remains entirely unknown if hypo-phosphorylated Rb contains one, two, three, five, seven or more phosphates, at what phosphate number hypo-phosphorylated Rb releases E2F transcription factors, what the phosphorylation kinetics are and what the biologically active form(s) of Rb during early G1 phase is. Here using highly synchronized normal and tumor cells combined with two-dimensional isoelectric focusing (2D IEF) to quantify the number of phosphates on Rb, we find no evidence to support the 20 year old notion that cyclin D:Cdk4/6 complexes progressively hypo-phosphorylate Rb. In contrast, we discovered that cyclin D:Cdk4/6 complexes exclusively mono-phosphorylates Rb throughout early G1 phase, and generates fourteen independent mono-phosphorylated Rb isoforms. Cells undergoing a DNA damage response activate cyclin D:Cdk4/6 complexes to generate mono-phosphorylated Rb that regulated global transcription, whereas non-phosphorylatable Rb remained non-functional. These observations fundamentally change our understanding of G1 cell cycle progression and show that mono-phosphorylated Rb, generated by cyclin D:Cdk4/6 complexes, is the functionally active isoform of Rb in early G1 phase. Citation Format: Steven F. Dowdy, Manuel Kaulich. Cyclin D:Cdk4/6 activates RB by mono-phosphorylation during early G1 phase. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1304. doi:10.1158/1538-7445.AM2014-1304
Plan for Amazonian jungle medicines is threatened
Authors: C. Wallerstein
Journal: BMJ (2000)

Ethnic and political arguments have paralysed an ambitious scheme to make an inventory of indigenous medicinal plants and remedies in Venezuela's Amazon jungle that could be used to develop drugs to fight cancer and AIDS. Preparations for the bioresearch project, involving 50 scientists from the Venezuelan Institute of Scien-tific Investigation and three Venezuelan universities, started with input from Oxford University's Foundation for Ethnobiology in 1991.

The project's director, Dr Fabian Michelangeli, said: “It's impossible to underestimate the potential of this. Venezuela ranks sixth in terms of world biodiversity, with at least 25000 species of plants, of which around 2000 have medicinal uses.” An exciting aspect of the project …
Depression and Survival Following Myocardial Infarction
Authors: Ming Wei
Journal: JAMA (1994)

To the Editor.  —We read with interest the article by Frasure-Smith et al 1 but noted problems that warrant comment. All of the confidence intervals (CIs) for the hazard ratios (HRs) are incorrect. We noted that eight risk factors in Table 2 had negative lower limits that are outside the range for a ratio. Second, the category daily smoker had lower limits greater than 1.0 with a P value reported to be.17. Since the 95% CI did not include 1.0, the HR is, by definition, statistically significant at the .05 level. Third, the reported CIs are symmetric around the HR, which will not occur since the value of 1.0 defines no effect and the minimum value must be positive.  The findings and interpretation of the multivariate analysis are also suspect. The bivariate analysis showed five factors besides major depression with HRs greater than 3.0. Each of these factors had a relatively
United States clears silicone breast implants
Authors: D. Josefson
Journal: BMJ (1999)

An independent panel of US scientists convened at the request of Congress has concluded that silicone breast implants do not cause any major disease but that they do frequently leak and rupture, causing local problems such as scarring, infection, and disfigurement. These last symptoms may result in the need for further surgery.

The panel was formed by 13 members of the Institute of Medicine, …
Renal Ischemia and Function After Partial Nephrectomy: A Collaborative Review of the Literature
Authors: Alessandro Volpe, Michael L. Blute, Vincenzo Ficarra, Inderbir S. Gill, Alexander Kutikov, Francesco Porpiglia, Craig Rogers, Karim A. Touijer, Hendrik Van Poppel, R. Houston Thompson
Journal: European Urology (2015)
Current Diagnosis &amp;amp; Treatment in Family Medicine
Authors: William B. Ventres
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Differential prognostic importance of QRS duration in heart failure and acute myocardial infarction associated with left ventricular dysfunction
Authors: Emil Loldrup Fosbøl, Marie Seibæk, Bente Brendorp, Daniél Vega Møller, Mads Ersbøll, Christian Torp‐Pedersen, Lars Køber
Journal: European Journal of Heart Failure (2007)
The American Health Care System Revisited — A New Series
Authors: Marcia Angell
Journal: New England Journal of Medicine (1999)

The American health care system is at once the most expensive and the most inadequate system in the developed world, and it is uniquely complicated. In 1997 we spent about $4,000 per person on health care, as compared with the next most expensive country, Switzerland, which spent some $2,500.1 Yet 16 percent of our population has no health insurance at all, and many of the rest have only very limited coverage. The hallmark of the system is its reliance on the private market to deliver and, to a lesser extent, to fund health care. Accordingly, health care is treated as . . .
Dermatitis herpetiformis: effect of gluten-free diet on skin IgA and jejunal structure and function.
Authors: C I Harrington, N W Read
Journal: BMJ (1977)

To clarify the controversy about the effectiveness of a gluten-free diet in dermatitis herpetiformis, 10 highly motivated patients were investigated. The indices used to assess improvement included deposition of sub-epidermal IgA in unaffected skin, counts of intraepithelial lymphocytes, deposition of IgA in jejunal villi, and electrical tests of glucose absorption. In every patient subepidermal IgA concentrations fell after gluten withdrawal. In all but one patient the dose of dapsone necessary to control symptoms was reduced. Indeed, six patients stopped taking the drug completely within a year. In nine patients biopsy specimens were taken from the jejunum; seven showed abnormalities in jejunal morphology, eight had increased numbers of intraepithelial lymphocytes, and five had increased numbers of IgA-reactive cells in the lamina propria. Two of these three indices improved after gluten withdrawal, which confirmed that all nine patients were adhering to their diet. Routine screening for malabsorption proved to be unsatisfactory for showing the mild jejunal disease found in patients with dermatitis herpetiformis. The electrical test of glucose absorption showed subnormal results in all eight patients tested, however, and in six the results improved after gluten withdrawal.
Man Bites Dog
Authors: Henry T. Ricketts
Journal: JAMA (1974)

The<i>American Medical News</i>, a publication of the American Medical Association (AMA), carried in its Dec 24, 1973, issue the information that the AMA had established a Committee to Improve Medical Care in the Nation's Correctional Institutions. The members include physicians, correctional facility experts, lawyers, and a psychiatrist, among others. The need for such action is evident: more than half of these institutions lack any medical facilities. Recently, in a Midwest penitentiary, a unique attempt to improve the lot of ill prisoners was undertaken. A group of inmates with diabetes mellitus and a disgruntled view of their medical care took things into their own hands, not with strikes, kidnapped guards, or riots, but with recourse to law. In a class action brought under the Civil Rights Act, and with the aid of civic-minded attorneys of private firms and of a Prison Legal Services Project, a suit was filed in a
25 CONTRAST-ENHANCED US: A SIMPLE, QUICK AND SENSITIVE TOOL IN THE DIFFERENTIAL DIAGNOSIS OF BENIGN AND MALIGNANT PORTAL VEIN THROMBOSIS IN CIRRHOTIC PATIENTS WITH HEPATOCELLULAR CARCINOMA
Authors: L. Tarantino, G. Francica, I. Sordelli, V. Nocera
Journal: Journal of Hepatology (2008)
Effect of diverging policy across the NHS
Authors: Arturo Alvarez-Rosete, Gwyn Bevan, Nicholas Mays, Jennifer Dixon
Journal: BMJ (2005)

Since 1948 the NHS has provided universal coverage that is free at the point of use, funded largely from taxation. Reforms have come and gone, but until the late 1990s they had been applied similarly across the four countries of the UK. Although the NHS has never been homogeneous, in practice the policy differences between the countries have been marginal compared with the similarities. However, in 1998 the Labour government devolved power to an elected parliament in Scotland, an elected assembly in Wales, and, until it was suspended in 2002, an elected assembly in Northern Ireland.

Although the powers of each political body differ, each has important freedoms with respect to NHS policy. As a result, in England, the emphasis has been on national targets to improve performance (particularly reducing waiting times), increasing capacity, and sharper market-style incentives. In Scotland, the 1990s quasi-market has been abolished and steps taken to build a professionally led, integrated system based on concepts such as managed clinical networks. In Wales, the focus has been on improving the public health through partnership working between the local NHS, local government, and communities, and in Northern Ireland, developments have been stalled by political uncertainty.1 2 What is the effect of these differences in emphasis of policy?

We used routine data on performance of the NHS in each country to compare health indicators for 2002-3 with those in 1996-7 (before devolution). The baseline data were from a previous study by one of the authors.3 We present six sets of indicators relating to health, per capita expenditure, inputs (such as staff and beds), activity (such as inpatient and day case rates), rates of selected operations, and other outputs (such as waiting times).

After collecting the data, we tried to contact people with overall responsibility for health statistics …
Survival Time Doubles
Authors: Rebecca Voelker
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Noninvasive predictors of nonalcoholic steatohepatitis in Korean patients with histologically proven nonalcoholic fatty liver disease
Authors: Young Seok Kim, Eun Sun Jung, Wonhee Hur, Si Hyun Bae, Jong Young Choi, Myeong Jun Song, Chang Wook Kim, Se Hyun Jo, Chang Don Lee, Young Sok Lee, Sang Wook Choi, Jin Mo Yang, Jeong Won Jang, Sang Gyune Kim, Seung Won Jung, Hee Kyung Kim, Hee Bok Chae, Seung Kew Yoon
Journal: Clinical and Molecular Hepatology (2013)

See the commentary-article "Noninvasive markers: a double-edged sword that stratifies nonalcoholic steatohepatitis" on page 116.
A proliferation-inducing ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase–regulated mammalian target of rapamycin activation
Authors: Mamta Gupta, Stacey R. Dillon, Steven C. Ziesmer, Andrew L. Feldman, Thomas E. Witzig, Stephen M. Ansell, James R. Cerhan, Anne J. Novak
Journal: Blood (2009)
Clinical Evaluation of a Disposable Artificial Kidney
Authors: A. E. Kulatilake, J. Vickers, R. Shackman
Journal: BMJ (1969)

The in-vivo performance of a new disposable parallel flow countercurrent type of artificial kidney has been compared with that of the modified four-layered Kiil dialyser. The dialysance of urea and endogenous creatinine in the former was significantly better than in the latter for similar blood flow rates, and, moreover, unlike the dialysance with the Kiil dialyser it continued to improve over 12 hours. Among 100 disposable artificial kidneys tested no failure occurred from blood leaks despite the use of high negative pressures in the dialysate compartment. No pyrogen reactions were observed.These new artificial kidneys were ready for use in less than one-seventh of the time taken to prepare the conventional Kiil dialyser. Other advantages are their low priming volumes, the lack of a pump in the blood line, and the reduced risk of infection.