tbuckley/cabot-search huggingface dataset:
Parse Analysis: A New Method for the Evaluation of Investigators' Bibliographies
Authors: Paul J. Davis, Robert I. Gregerman
Journal: New England Journal of Medicine (1969)

DURING the past five years our laboratory has been concerned with the development of a quantitative system for describing the relative contributions of authors to multiple-author manuscripts. The concept that has evolved is termed "parse analysis" and has been logically broadened to include the measurement of manuscript quality. This report reviews the basic principles of parse analysis and describes their recent application to the evaluation of scientific careers. We emphasize the point that the principles outlined here are the product of cooperative efforts of a host of scientists — many of them from abroad and elsewhere — working in our . . .
Thyroid-stimulating hormone and insulin-like growth factor-1 synergize to elevate 1,2-diacylglycerol in rat thyroid cells. Stimulation of DNA synthesis via interaction between lipid and adenylyl cyclase signal transduction systems.
Authors: L Brenner-Gati, K A Berg, M C Gershengorn
Journal: Journal of Clinical Investigation (1988)

Thyroid-stimulating hormone (TSH) and insulin-like growth factor-1 (IGF-1) synergistically stimulate DNA synthesis in thyroid cells. In this report, a novel mechanism for mediation of this synergistic interaction is described in rat thyroid (FRTL-5) cells. Because phorbol myristate acetate stimulates DNA synthesis, the effects of TSH, IGF-1 and insulin on FRTL-5 cell content of 1,2-diacylglycerol (1,2-DG), the endogenous activator of protein kinase C, were measured. After 6 d, TSH, IGF-1 and insulin caused increases in cellular 1,2-DG (mean +/- SE) to 180 +/- 10%, 540 +/- 50%, and 360 +/- 40% of control, respectively, whereas TSH plus IGF-1 and TSH plus insulin synergistically increased 1,2-DG to 1,890 +/- 310% and 1,690 +/- 230%, respectively. In the absence of insulin, the effect of TSH to elevate 1,2-DG exhibited an EC50 of approximately 2,000 microU/ml. The synergistic interaction of insulin and TSH was found to increase the potency of TSH by 300-fold (EC50 was approximately 7 microU/ml) in addition to increasing the efficacy of TSH. The effect of TSH appeared to be mediated by TSH-stimulated increases in cyclic AMP (cAMP). Forskolin and 8-bromo-cAMP, like TSH, caused modest increases in 1,2-DG and DNA synthesis, whereas forskolin plus insulin and 8-bromo-cAMP plus insulin markedly elevated 1,2-DG content and stimulated DNA synthesis. Under all conditions, increases in 1,2-DG content correlated with stimulation of DNA synthesis. These findings suggest that the synergistic stimulation of DNA synthesis in thyroid cells by TSH, via cAMP, and IGF-1 is mediated by 1,2-DG. Moreover, they implicate a novel interaction between the lipid and adenylyl cyclase signaling systems for the regulation of cell proliferation.
Neuroscience 2000: A New Era of Discovery
Authors: Doris Margolis
Journal: Annals of Internal Medicine (1999)

Currents17 August 1999Neuroscience 2000: A New Era of DiscoveryDoris MargolisDoris MargolisSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-4-199908170-00102 SectionsAboutFull Text ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Neuroscientists converged at the National Academy of Scientists in Washington, D.C., on April 12 and 13 to compare notes and bring each other up to date about research developments engineered during the Decade of the Brain, 1990-1999. The giants of the field were there in force, some on the official program, and others—like Nobel prize winner Julius Axelrod, PhD—in the audience. Sponsored by the Washington-based Society for Neuroscience, the conference took place on the eve of Congressional hearings on medical research funding.A Wide Array of TopicsThe meeting focused on the scientific advances achieved in this decade and how ... Author, Article, and Disclosure InformationAuthors: Doris Margolis PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 August 1999Volume 131, Issue 4Page: 318-320KeywordsBrainDrug addictionDrugsEmotionsMemoryNervous systemNeurodegenerative diseasesNeuronsParkinson diseaseStroke ePublished: 15 August 2000 Issue Published: 17 August 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.Loading ...
The Alcohol Prescription
Authors: F. A. Meister
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The Oct 12 editorials in The Journal by Drs Lundberg<sup>1</sup>and Niven<sup>2</sup>reflect a disturbing trend of thought in medical and other circles. While these men offer some sound advice, such as the need for improved doctor-patient communication about alcohol and the need for improved medical training on alcohol, they fail in the attempt to write a prescription for society based only on a list of negative symptoms. They appear begrudgingly to accept alcohol only in zero-risk situations and appear unwilling to accept any concept that there is value in drinking customs that have endured and evolved since the birth of mankind. They both seem to fall into a trap created by the abundance of statistical estimates on the costs and frequency of tragedies associated with alcohol. They are quick to assume that beverages, not individuals, are responsible for all deaths and injuries that occur in the presence of those
Abstract 3236: Role of mouse and human CYP2A enzymes in the bioactivation of the tobacco-specific lung procarcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
Authors: Xinxin Ding, Xin Zhou
Journal: Cancer Research (2011)

Abstract NNK is a potent lung procarcinogen. Previously, we have demonstrated that NNK-induced lung tumorigenesis depends on target-tissue metabolic activation by pulmonary P450 enzymes. The aim of this study is to test the hypotheses that 1) mouse CYP2A5 plays an essential role in NNK bioactivation in the lung, and 2) transgenic expression of human CYP2A13, known to be selectively expressed in the respiratory tract, and be the most efficient enzyme for NNK metabolic activation in vitro, can increase the rates of NNK metabolic activation in the mouse lung. We determined the rates of in vitro formation of 4-oxo-4-(3-pyridyl)-butanal (OPB), representing the reactive intermediate that can lead to the further formation of O6-mehtylguanine (O6-mG) DNA adduct, in liver and lung microsomes of wild-type, Cyp2a5-null, and CYP2A13-humanized (CYP2A13-transgenic/Cyp2a5-null) mice. We found that, in both liver and lung microsomes, the loss of CYP2A5 resulted in significant decreases in the rates of formation of OPB; whereas, the gain of CYP2A13 led to recovery of the microsomal activity in the lung, but not in the liver. Furthermore, we observed that the levels of O6-mG, the DNA adduct known to be most highly correlated with incidences of lung tumor formation, were significantly higher in the lungs of the CYP2A13-humanized mice, than in the Cyp2a5-null mice. In control experiments, rates of systemic clearance of NNK and its major circulating metabolite, NNAL, were confirmed to be not different among the three mouse strains. These results indicate that CYP2A13 can catalyze NNK bioactivation in vivo, and they support the idea that CYP2A13 genetic polymorphisms can influence the risks of tobacco-induced lung tumorigenesis in humans. (Supported in part by NIH grant CA092596) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3236. doi:10.1158/1538-7445.AM2011-3236
Human monoclonal antibodies from a patient with primary biliary cirrhosis that recognize two distinct autoepitopes in the E2 component of the pyruvate dehydrogenase complex
Authors: Mieko Matsui, Minoru Nakamura, Hiromi Ishibashi, Kichiko Koike, Jiro Kudo, Yoshiyuki Niho
Journal: Hepatology (1993)

Peripheral B lymphocytes from a patient with primary biliary cirrhosis were infected with Epstein-Barr virus, and Epstein-Barr virus-transformed B lymphocytes producing large amounts of IgG antibodies to pyruvate dehydrogenase complex were selected, expanded and fused with the human-mouse heteromyeloma cell line F3B6. The resulting Epstein-Barr virus-transformed B-cell hybrids were repeatedly cloned by limiting dilution, and three stable hybridoma clones producing human monoclonal antibodies to pyruvate dehydrogenase complex were generated. These monoclonal antibodies, designated M18GP8, M37GP11 and M82GP8, specifically bound to pyruvate dehydrogenase complex, and their dissociation constant with pyruvate dehydrogenase complex was calculated to be 2.4 x 10(-11), 2.3 x 10(-10) and 2.6 x 10(-11) mol/L, respectively. These three monoclonal antibodies stained the mouse stomach/kidney cryostat sections in a typical immunofluorescence pattern of antimitochondrial antibody. Furthermore, the enzymatic activity of pyruvate dehydrogenase complex was almost completely inhibited by the three monoclonal antibodies. Western blotting analysis revealed that M18GP8 and M82GP8 reacted with only pyruvate dehydrogenase complex-E2 in contrast to M37GP11, which reacted with both pyruvate dehydrogenase complex-E2 and protein X. The binding of monoclonal antibody M37GP11 to solid-phase pyruvate dehydrogenase complex was partially inhibited by two different synthetic peptides corresponding to both the inner and outer lipoyl-binding domains of pyruvate dehydrogenase complex-E2. These monoclonal antibodies, which are the first human monoclonal antibodies to pyruvate dehydrogenase complex generated from a patient with primary biliary cirrhosis, will be a valuable tool for studying the B-cell autoepitopes in PDC and the mechanism of autoantibody production in primary biliary cirrhosis.
Can we predict the duration of chemotherapy-induced neutropenia in febrile neutropenic patients, focusing on regimen-specific risk factors? A retrospective analysis
Authors: Y. Lalami, M. Paesmans, F. Muanza, M. Barette, B. Plehiers, L. Dubreucq, A. Georgala, J. Klastersky
Journal: Annals of Oncology (2005)
Autotransplantation of Adrenal Remnant to Thigh in Cushing's Disease
Authors: James D. Hardy
Journal: JAMA (1963)

THE SURGICAL MANAGEMENT of Cushing's syndrome due to bilateral adrenocortical hyperplasia has always presented two hard choices. Onthe one hand, total adrenalectomy abolished the hyperadrenocorticalism, but produced permanent loss of adrenocortical function. At times this resulted in hyperpigmentation apparently due to increased pituitary elaboration of melanophore-stimulating hormone. On the other hand, subtotal adrenalectomy entailed the risk that regeneration of the residual adrenal remnant might produce recurrence of the original disease, necessitating a second and often more difficult laparotomy. It occurred to us that autotransplantation of the adrenal remnant to the thigh might provide residual adrenocortical function while precluding the need for a second laparotomy in the event of recurrence of hyperadrenocorticalism. In leaving a nubbin of left adrenal gland attached to the left renal vein by only the central adrenal vein, we had frequently achieved survival of this adrenal tissue despite the fact that it was supplied solely by venous
Correction: Temperature Correction for Oxygen Tension
Authors: JAMES B. REULER
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 May 1979Correction: Temperature Correction for Oxygen TensionJAMES B. REULER, M.D.JAMES B. REULER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-5-859_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A commentary from me in the February 1979 issue (1) contains an error I failed to detect in the original manuscript.The error occurs in the example I used to illustrate blood gas correction. It should read, "For example, a patient with a core temperature of 27 °C and a pH of 7.10 and a Po2of 75 mm Hg would have, with correction for temperature, a tissue-level pH of 7.25 and a Po2of 20 mm Hg." The original listed the first Po2as 20 mm Hg....Reference1. REULER J: Hypothermia (letter). Ann Intern Med 90:273, 1979 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES B. REULER, M.D.Affiliations: Veterans Administration Hospital Portland, OR 97207 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1979Volume 90, Issue 5Page: 859-859KeywordsBloodOxygenPartial pressure of oxygenTemperature ePublished: 1 December 2008 Issue Published: 1 May 1979 PDF downloadLoading ...
ACC/AHA/ACP–ASIM Guidelines for the Management of Patients With Chronic Stable Angina: Executive Summary and Recommendations
Authors: Raymond J. Gibbons, Kanu Chatterjee, Jennifer Daley, John S. Douglas, Stephan D. Fihn, Julius M. Gardin, Mark A. Grunwald, Daniel Levy, Bruce W. Lytle, Robert A. O’Rourke, William P. Schafer, Sankey V. Williams, James L. Ritchie, Raymond J. Gibbons, Melvin D. Cheitlin, Kim A. Eagle, Timothy J. Gardner, Arthur Garson, Richard O. Russell, Thomas J. Ryan, Sidney C. Smith
Journal: Circulation (1999)
Current Concepts in Ophthalmology
Authors: Arnall Patz
Journal: JAMA (1977)

This text is a product of the faculty of the Department of Ophthalmology, University of Florida, Gainesville. Most of the faculty who have contributed to this journal are contemporary or past members of this program. The authors have not attempted to make this a standard textbook or source of reference, "but rather it is intended to stimulate the reader by emphasizing newer knowledge and concepts in important areas of ophthalmology and pointing out the questions that remain to be answered in these areas." In view of the pioneer contributions of Dr Kaufman in the field of corneal diseases and surgery, there is a proportionately larger number of contributions in this and related subjects. Representing one of the leading corneal centers in this country, these essays are authoritatively written and provide a considerable amount of new and useful information to the practicing ophthalmologist and to the specialist in corneal diseases. There
Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis
Authors: Tom H. Karlsen, Kirsten Muri Boberg, Marita Olsson, Ji-Yao Sun, David Senitzer, Annika Bergquist, Erik Schrumpf, Erik Thorsby, Benedicte A. Lie
Journal: Journal of Hepatology (2007)
Myoglobinuria Following Aminocaproic Acid Administration
Authors: Robert Allan Rizza, Stuart Sclonick, C. Lockard Conley
Journal: JAMA (1976)

<h3>To the Editor.—</h3> ε-Aminocaproic acid (EACA), a specific inhibitor of plasminogen activation, was originally used in low dosage as an antifibrinolytic agent and is now being employed in higher doses in the treatment of hereditary angioneurotic edema. We have recently encountered a 24-year-old woman receiving high doses of EACA who had rhabdomyolysis and myoglobinuria. <h3>Report of a Case.—</h3> The patient, previously reported in detail by Little and Bell,<sup>1</sup>has had recurrent painful subcutaneous hemorrhages ascribed to DNA sensitivity for sixteen years. She was initially treated with chloroquine, but approximately seven years ago hemorrhages recurred with increasing frequency. The chloroquine regimen was discontinued, and she was treated with EACA (5 gm when she was symptomatic followed by 1 gm every hour for a maximum of 12 hours). This regimen was followed episodically, at most four to five times per month. After her most recent hemorrhage a course of continuous EACA
Bacterial Infections Promote T Cell Recognition of Self-Glycolipids
Authors: Gennaro De Libero, Anthony P. Moran, Hans-Jürgen Gober, Emmanuel Rossy, Abdijapar Shamshiev, Olga Chelnokova, Zaima Mazorra, Silvia Vendetti, Alessandra Sacchi, Martina M. Prendergast, Sebastiano Sansano, Alexander Tonevitsky, Regine Landmann, Lucia Mori
Journal: Immunity (2005)
A Comparison of the Clinical Impact of Bleeding Measured by Two Different Classifications Among Patients With Acute Coronary Syndromes
Authors: Sunil V. Rao, Kristi O’Grady, Karen S. Pieper, Christopher B. Granger, L. Kristin Newby, Kenneth W. Mahaffey, David J. Moliterno, A. Michael Lincoff, Paul W. Armstrong, Frans Van de Werf, Robert M. Califf, Robert A. Harrington
Journal: Journal of the American College of Cardiology (2006)
INHIBITORS AND PROACTIVATORS OF FIBRINOLYSIS IN HUMAN EPIDERMIS
Authors: KIYOSHI NISHIOKA, TERENCE J. RYAN
Journal: British Journal of Dermatology (1971)

Journal Article INHIBITORS AND PROACTIVATORS OF FIBRINOLYSIS IN HUMAN EPIDERMIS Get access KIYOSHI NISHIOKA, KIYOSHI NISHIOKA Institute of Dermatology, London, E.9 Search for other works by this author on: Oxford Academic Google Scholar TERENCE J. RYAN TERENCE J. RYAN Institute of Dermatology, London, E.9 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 85, Issue 6, 1 December 1971, Pages 561–565, https://doi.org/10.1111/j.1365-2133.1971.tb14083.x Published: 01 December 1971 Article history Accepted: 29 June 1971 Published: 01 December 1971
Polybrominated biphenyl (PBB) contamination of the Pine River, Gratiot, and Midland Counties, Michigan.
Authors: J L Hesse, R A Powers
Journal: Environmental Health Perspectives (1978)

Michigan Chemical Corporation, St. Louis, Michigan manufactured PBB from 1970 until November 20, 1974. Studies in 1974 showed significant quantities of PBB in effluent discharged from the facility and in water, fish, ducks, and sediments from the Pine River. Fish uptake rates and bioconcentration factors were estimated. Followup surveys over the three year period since the termination of PBB production indicate a decline in PBB loadings to the river but no significant corresponding decline of PBB levels in sediments, fish and duck tissue. A Michigan Department of Public Health warning against consumption of Pine River fish from St. Louis downstream to its confluence with Chippewa River remains in effect.
Preventing Opportunistic Infections in Persons Infected With HIV: 1997 Guidelines
Authors: Jonathan E. Kaplan
Journal: JAMA (1997)

AN ESTIMATED 650 000 to 900 000 residents of the United States are currently infected with human immunodeficiency virus (HIV), the cause of acquired immunodeficiency syndrome (AIDS).<sup>1</sup>Opportunistic infections (OIs) exact a great toll in terms of morbidity and mortality among the estimated 200 000 to 250 000 persons with severe immunosuppression, as defined by a CD4<sup>*</sup>T-lymphocyte count of less than 0.20x10<sup>9</sup>/L.<sup>2,3</sup>Data collected from 1990 to 1994 suggest that the 1- and 2-year incidence rates of any AIDS-defining illness in this population were 33% and 58%.<sup>4</sup>The direct costs of the HIV epidemic in the United States, most of which have resulted from hospitalizations for these illnesses, were projected to reach $15 billion for the year 1995.<sup>5</sup>Although the incidence of OIs appears to be decreasing because of antiretroviral therapy and chemoprophylaxis against specific OIs—at least in some HIV-infected populations<sup>6</sup>—prevention
A high expression EGFR/cell membrane chromatography and online high performance liquid chromatography/mass spectrometry method for screening EGFR antagonists from Rhizoma Polygoni Cuspidati
Authors: Meng Sun, Yan-min Zhang, Jie Zhang, Si-cen Wang, Lang-chong He
Journal: Acta Pharmaceutica Sinica B (2011)

The epidermal growth factor receptors (EGFRs) in some tumor cells are significant targets for drug discovery. In this work, we have developed an EGFR cell membrane chromatography and online high performance liquid chromatography/mass spectrometry system for screening active component from Rhizoma Polygoni Cuspidati. As a result, resveratrol from Rhizoma Polygoni Cuspidati was found to be the active component acting on EGFR like gefitinib. There was a good relationship between their inhibiting effects on EGFR secretion and HEK293 EGFR cell growth in vitro. The EGFR/CMC-online-HPLC/MS system demonstrated fast and effective characteristics for screening leading compounds from traditional Chinese medicine.
Nail-Patella Syndrome Image Correlation
Authors: JOHN R. STY, ROBERT G. WELLS, DAVID C. GREGG
Journal: Clinical Nuclear Medicine (1992)

The nail-patella syndrome is an autosomal dominant disorder characterized by deformities of a variety of mesodermal and ectodermal elements. Most affected patients exhibit hypoplasia, dysplasia, or absence of the fingernails and toenails. Other common sites of involvement include the skin, kidneys, pelvis, knees, and elbows. In many cases, the earliest radiographic manifestations of this disorder in infants and children is osteocartilaginous exostoses (“iliac horns”) of the iliac wings. These exostoses may be detected with skeletal scintigraphy, and should not be confused with other pathologic conditions.
Risk of Lung Cancer According to Histologic Type and Cigarette Dosage
Authors: William Weiss
Journal: JAMA (1972)

The risk of developing various histologic types of bronchogenic carcinoma was determined in a ten-year prospective study of 6,136 older men in relation to smoking habits at the beginning of observation. No lung cancer developed in 830 nonsmokers. Among the 2,580 men who regularly smoked cigarettes only and who were current smokers on entry, the risk of lung cancer increased with increasing daily cigarette consumption. The cancers were typed according to a modification of the World Health Organization classification. Well-differentiated squamous-cell carcinoma, small-cell carcinoma, and adenocarcinoma showed a dose-response relationship to cigarette smoking, but poorly differentiated squamous-cell carcinoma did not.
CAROTENOIDS IN MAN. III. THE MICROSCOPIC PATTERN OF FLUORESCENCE IN ATHEROMAS, AND ITS RELATION TO THEIR GROWTH1
Authors: David H. Blankenhorn, Herbert Braunstein
Journal: Journal of Clinical Investigation (1958)

In a previous study of the carotenoid content of human aortic atherosclerosis it was concluded by Blankenhorn, Freiman, and Knowles that these dietary lipids accumulate in direct proportion to the extent and relative age of the lesions in which they occur.A series of graded aortic segments was assayed, and it was found that increased severity of atherosclerosis was accompanied by a parallel increase in the concentration of carote- noids (1).Exact location of these pigments in relation to the microscopic anatomy of atherosclerotic lesions should aid in evaluation of the role of exogenous lipids of this class in the initiation of atheromas and their continued growth.It seemed possible that this might be accomplished by fluorescence microscopy, since carotenoids and vitamin A, on exposure to ultraviolet light, produce a characteristic pale green fluorescence by which they can be exactly localized and roughly quantitated in tissue sections (2).Although Popper (2), and Hamperl (3), who performed surveys of the fluorescence in human tissue, reported no evidence of carotenoids or vitamin A in atheromas, it was decided to reinvestigate this matter in view of the findings of Blankenhorn, Freiman, and Knowles.The surveys of Popper and Hamperl were performed on tissues fixed in formalin, a pro- cedure known to diminish the fluorescence of carotenoids and vitamin A. Therefore, in the study here reported unfixed atheromas were examined.Green fluorescence was found and evidence will be presented to show that this fluorescence is a valid means of localizing carotenoids and/or 'Supported in part by grants-in-aid from the American