tbuckley/cabot-search huggingface dataset:
Antigens Common to Scabies and House Dust Mites
Authors: Edvard S. Falk, Siri Dale, Roald Bolle, Bjørn Haneberg
Journal: Allergy (1981)

Twenty‐five antigens were demonstrated in a crude Dermatophagoides farinae (DF) extract by means of crossed immunoelectrophoresis (CIE), using a rabbit anti‐DF serum. With the same antiserum, four antigens were demonstrated in a scabies mite preparation, indicating an immunological relationship between these scabies antigens and some of the DF antigens. In tandem CIE experiments the DF antigens were found to be partly identical to three of the scabies antigens. No IgE activity against any of these scabies antigens was evident in pooled sera from patients with house dust mite allergy by crossed radioimmunoelectrophoresis. However, one such patient had IgE antibodies to a DF antigen and a partial identical scabies antigen.
Building the Best Team
Authors: Robert Matz
Journal: Annals of Internal Medicine (1998)

Letters15 February 1998Building the Best TeamRobert Matz, MDRobert Matz, MDThe Mount Sinai Medical Center; New York, NY 10029Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-4-199802150-00042 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I would like to comment on the sports analogy in Nash and Nash's editorial [1]. In an earlier era it was believed, naively even then, that “… the point of fielding a team is to win games” instead of focusing on money. That, to be polite, does not compute today. When sports figures command mega-buck salaries and, via free agency, chase “the green,” and when owners move franchises for even better deals, the concept of winning is only a means to an end. That era in medicine was also “the days of the Giants.”The current focus ...References1. Nash DB, Nash IS. Building the best team [Editorial]. Ann Intern Med. 1997; 127:72-4. Google Scholar Author, Article, and Disclosure InformationAffiliations: The Mount Sinai Medical Center; New York, NY 10029 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1998Volume 128, Issue 4Page: 327-328KeywordsGamesSports Issue Published: 15 February 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Results of Valvulotomy for Valvular Pulmonary Stenosis with Intact Ventricular Septum
Authors: DON M. HOSIER, JOHN L. PITTS, HELEN B. TAUSSIG
Journal: Circulation (1956)

The analysis deals primarily with follow-up studies of patients who have had a valvulotomy for valvular pulmonic stenosis with an intact ventricular septum. In addition to observations on the subjective improvement, hemograms, and arterial oxygen saturation, the cardiac findings have been analyzed in detail. The changes in the size of the heart have been studied in relation to the growth of the patient and, wherever possible, these changes have been correlated with the postoperative right ventricular pressure. It was found that cardiac enlargement came to an end when the right ventricular pressure fell below 100 mm. Hg.
Multicenter, Randomized, Phase II Trial of CI-1033, an Irreversible Pan-ERBB Inhibitor, for Previously Treated Advanced Non–Small-Cell Lung Cancer
Authors: Pasi A. Jänne, Joachim von Pawel, Roger B. Cohen, Lucio Crino, Charles A. Butts, Steven S. Olson, Irene A. Eiseman, Alberto A. Chiappori, Beow Y. Yeap, Peter F. Lenehan, Kathy Dasse, Meredith Sheeran, Philip D. Bonomi
Journal: Journal of Clinical Oncology (2007)

To evaluate the efficacy of the pan-ERBB inhibitor, CI-1033, in platinum-refractory or recurrent advanced-stage non-small-cell lung cancer (NSCLC).This open-label, randomized phase II trial evaluated CI-1033 in patients with advanced-stage NSCLC who experienced treatment failure after or were refractory to platinum-based chemotherapy. Three oral CI-1033 doses were evaluated in 21-day dosing cycles: 50 mg daily for 21 consecutive days, 150 mg daily for 21 consecutive days, and 450 mg daily for 14 consecutive days followed by 7 days of no treatment. The primary efficacy end point was the 1-year survival rate.One hundred sixty-six patients were randomly assigned to treatment. Baseline patient demographics were well balanced. The most common drug-related adverse events were rash and diarrhea. The 450-mg arm (14 days on/7 days off) was closed early due to an excessive rate of adverse events. The 1-year survival rates were 29%, 26%, and 29%, respectively, in the three arms. The response rates were 2%, 2%, and 4%, and stable disease was confirmed in 16%, 23%, and 18% of patients, respectively, in the three study arms. Exploratory analyses demonstrated a prolonged survival in patients who developed a rash and in those with baseline tumor ERBB-2 expression.CI-1033 had modest activity in unselected NSCLC patients but did not meet its primary end point. Future studies should focus on identifying methods of patient selection.
PYELOVENOUS BACK FLOW
Authors: FRANK HINMAN
Journal: JAMA (1926)

Pyelovenous back flow is the name that was applied in 1923<sup>1</sup>to the phenomenon of drainage into the venous system from the renal pelvis under certain conditions of back pressure. In routine injection methods for demonstrating renal circulation,<sup>2</sup>a cast of the renal pelvis is often made to demonstrate the relationship of its outline to the arterial blood supply, and it was a frequent occurrence to have extrapelvic extravasation even with moderate pressures. This had been a frequent observation of others in injection methods. From the experimental side, as early as 1856, Gigon,<sup>3</sup>using potassium iodide and starch, demonstrated the passage of fluid by way of the venous plexus on the surface of the calices from the pelvis in both cadaver and living kidneys. Both Poirier<sup>4</sup>in 1891 and Tuffier<sup>5</sup>in 1894 noted a marked difference of absorption with and without ureteral obstruction. A lethal
Safety and efficacy of pegfilgrastim in pediatric solid tumor patients (pts).
Authors: L. De Sio, R. Pessolano, M. De Pasquale, P. Fidani, R. Cozza, C. De Laurentis, I. Ilari, M. De Ioris, A. Jenkner, A. Donfrancesco
Journal: Journal of Clinical Oncology (2010)

e20007 Background: Progressive intensification of chemo-radiotherapy regimens has led to improved outcome of children with solid tumors. Marrow toxicity and neutropenia have become the main dose-limiting toxicities, often resulting in life-threatening infectious complications. Hematopoietic growth factors were introduced into clinical practice to minimize these complications. Recently Pegfilgrastim, a PEG-conjugated form of r-metHuG-CSF (filgrastim) with much longer serum half-life and a comparable safety and efficacy profile in adults has become available. We describe our retrospective institutional experience with Pegfilgrastim after myelosuppressive chemotherapy in children with solid tumours. Methods: Pts received a single subcutaneous injection of Pegfilgrastim, administered 72-96 hours after the completion of chemotherapy, at the dose of 100 μ g/kg (in children < 40 kg of weight) or 6 mg flat dose (in pts > 40 kg). Diagnoses were: CNS tumours (3), neuroblastoma (6), rhabdomyosarcoma (3), Ewing sarcoma (6), renal cancer (1) and other solid tumors (3). We analyzed: incidence and duration of grade IV neutropenia, presence and length of fever, incidence of bacteremia, absolute neutrophil count (ANC) nadir, number of platelet (Plt) and packed red blood cell (PRBC) transfusions, PBSC harvests and incidence of adverse events. Results: Between February 2008 and April 2009, 22 patients, M/F 13/9, median age 70 months (range 26-191), median body weight 19.2 kg (range 14-60.5) received 80 doses. We observed: grade IV neutropenia in 86% of courses, median ANC nadir of 0.03×109/L (range 0- 3.360×109/L), median recovery time of 14 days (range 8-30) and median duration of grade IV neutropenia of 4 days (range 0-16). Febrile neutropenia occurred in 58% of courses, with 7 cases of documented sepsis; patients received 88 PRBC transfusions and 148 Plt transfusions. 83% of PBSC harvests were successful, with a median harvest of 6,7 × 106 CD34+ cells/kg (range 2.16-60); no significant adverse events were recorded. Conclusions: A single dose of pegfilgrastim per chemotherapy course is as safe and effective as daily filgrastim in children with solid malignancies both in enhancing neutrophil recovery and in CD34+ mobilization. No significant financial relationships to disclose.
Lymph Node Examination Rate, Survival Rate, and Quality of Care in Colon Cancer
Authors: Karl Y. Bilimoria, Andrew K. Stewart, Stephen B. Edge, Clifford Y. Ko
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sexually transmitted infections: control strategies
Authors: M. Catchpole
Journal: BMJ (2001)

Clinical Review p 1160 

Sexually transmitted infections, including HIV and hepatitis B, remain one of the greatest global public health challenges. Over the past five years notable rises have been observed in the United Kingdom in the incidence of genital chlamydial infection (76%), gonorrhoea (55%), and infectious syphilis (54%)1; such sustained rises have not been seen since the late 1960s and 1970s.2 Similar increases have also been seen in other countries in Western3 and Eastern4 Europe and the United States.5 The highest rates of sexually transmitted infections occur among 16-24 year olds, particularly older teenagers.1 Ethnic and socioeconomic inequalities in sexually transmitted infection rates exist in the US5 and the UK,6 with higher rates among black ethnic groups and lower socioeconomic groups. If we are to reverse these trends and reduce inequalities we need to understand their underlying determinants.

Some rises may reflect improved detection, particularly for genital chlamydial infection (with new diagnostic technologies), and deteriorating healthcare infrastructure (in the former states of the USSR). However, the major factor behind the …
Prevalence of Alcohol Use Disorders Before and After Bariatric Surgery
Authors: Wendy C. King, Jia-Yuh Chen, James E. Mitchell, Melissa A. Kalarchian, Kristine J. Steffen, Scott G. Engel, Anita P. Courcoulas, Walter J. Pories, Susan Z. Yanovski
Journal: JAMA (2012)

Context Anecdotal reports suggest bariatric surgery may increase the risk of alcohol use disorder (AUD), but prospective data are lacking.Objective To determine the prevalence of preoperative and postoperative AUD, and independent predictors of postoperative AUD. Design, Setting, and ParticipantsA prospective cohort study (Longitudinal Assessment of Bariatric Surgery-2) of adults who underwent bariatric surgery at 10 US hospitals.Of 2458 participants, 1945 (78.8% female; 87.0% white; median age, 47 years; median body mass index, 45.8) completed preoperative and postoperative (at 1 year and/or 2 years) assessments between 2006 and 2011.Main Outcome Measure Past year AUD symptoms determined with the Alcohol Use Disorders Identification Test (indication of alcohol-related harm, alcohol dependence symptoms, or score Ն8). ResultsThe prevalence of AUD symptoms did not significantly differ from 1 year before to 1 year after bariatric surgery (7.6% vs 7.3%; P=.98), but was significantly higher in the second postoperative year (9.6%;P=.01).The following preoperative variables were independently related to an increased odds of AUD after bariatric surgery: male sex (adjusted odds ratio [AOR], 2.14 [95% CI, 1.51-3.01];PϽ.001), younger age (age per 10 years younger with preoperative AUD: AOR, 1.31 [95% CI, 1.03-1.68],P=.03; age per 10 years younger without preoperative AUD: AOR, 1.95 [95% CI, 1.65-2.30],PϽ.001), smoking (AOR, 2.58 [95% CI, 1.19-5.58];P=.02), regular alcohol consumption (Ն2 drinks/week: AOR, 6.37 [95% CI, 4.17-9.72];PϽ.001), AUD (eg, at age 45, AOR, 11.14 [95% CI, 7.71-16.10];PϽ.001), recreational drug use (AOR, 2.38 [95% CI, 1.37-4.14];P=.01), lower sense of belonging (12-item Interpersonal Support Evaluation List score per 1 point lower: AOR, 1.09 [95% CI, 1.04-1.15];P=.01), and undergoing a Roux-en-Y gastric bypass procedure (AOR, 2.07 [95% CI, 1.40-3.08];PϽ.001; reference category: laparoscopic adjustable gastric band procedure). ConclusionIn this cohort, the prevalence of AUD was greater in the second postoperative year than the year prior to surgery or in the first postoperative year and was associated with male sex and younger age, numerous preoperative variables (smoking, regular alcohol consumption, AUD, recreational drug use, and lower interpersonal support) and undergoing a Roux-en-Y gastric bypass procedure.
Atopy patch test in patients with atopic eczema/dermatitis syndrome: comparison of petrolatum and aqueous solution as a vehicle
Authors: J. M. Oldhoff, I. C. Bihari, E. F. Knol, C. A. F. M. Bruijnzeel‐Koomen, M. S. de Bruin‐Weller
Journal: Allergy (2004)

Background: The atopy patch test (APT) is an in vivo model to study the induction of eczema by inhalant allergens. This study was designed to compare two commonly used APT methods. Methods: In the first method, the allergen is dissolved in aqueous solution, which is applied on tape‐stripped skin. In the second method, the allergen is dissolved in petrolatum and applied without tape stripping. Thirteen patients with atopic dermatitis sensitized to inhalant allergens were patch tested using both methods. Reactions were evaluated macroscopically and microscopically after 48 h. Results: Nine out of 13 patients displayed a positive reaction for both methods. One patient had a positive APT for the aqueous method alone and three for the petrolatum method alone. Reactions were significantly stronger when using the petrolatum method. Histological evaluation of the nine patients positive for both methods showed no significant differences in number of eosinophils, T‐cells and neutrophils. Conclusion: The APT using the petrolatum vehicle induces a higher number of positive reactions and is significantly stronger relative to the APT using allergen in aqueous vehicle. The cellular influx in both test methods is comparable. Both methods can be used to study the mechanisms in the induction of eczema by inhalant allergens.
Malignancy-associated multicentric reticulohistiocytosis: a clinical, histological and immunophenotypic study
Authors: J. L. SNOW, S. A. MULLER
Journal: British Journal of Dermatology (2006)

The clinical, histopathological, and immunophenotypic characteristics of four cases of malignancy associated multicentric reticulohistiocytosis (MMR) and one case each of diffuse cutaneous reticulohistiocytosis (OCR) and isolated reticulohistiocytoma (IR). are reviewed. In all four cases of MMR the cutaneous lesions and joint manifestations were judged to be concurrent with the diagnosis of malignancy. Malignancies observed included one case each of pancreatic adenocarcinoma, squamous cell carcinoma of the lung, metastatic melanoma and intraperitoneal grade 4 mucinous adenocarcinoma of uncertain origin. Histologically, all six cases demonstrated the typical changes of a diffuse histiocytic and multinucleated giant cell infiltrate with ground-glass cytoplasm, predominantly in the upper dermis. Immunohistochemical investigation revealed strong cytoplasmic staining with KP-1 (CD68) in all six cases. Prominent membrane staining was noted with leucocyte common antigen (CD45) in four cases (three MMR and one fR), and CD3 in four cases (three MMR and one IR). Weak membrane staining with Leu 22 (CD43) was noted in two MMR cases. UCHL-1 (CD45RO), L26 (CD20), S-100 and BerH2 stains were all uniformly negative. A prominent number of perilesional factor XIIIa-positive dermal dendrocytes were noted in the single case of IR, in contrast with the other five cases. We conclude that MMR, DCR and IR are histopathologically and immunohistochemically similar. The pattern of immunoreactivity observed is consistent with a monocyte-macrophage origin of the infiltrating tumour cells. We emphasize the paraneoplastic association of multicentric reticulohistiocytosis, which we have observed in four of 13 such cases (31%) evaluated at our institution.
Benefits and Risks of Exercise
Authors: Kevan C. Herold
Journal: JAMA (1983)

<h3>To the Editor.—</h3> We enjoyed the article by Koplan and co-workers on the benefits and risks of running in the Dec 17 issue ofThe Journal(1982; 248:3118). They showed that despite the interest and study of the direct impact of aerobic exercise on the cardiovascular system, there are many indirect benefits of this type of exercise that may have more importance in the long run. These effects include the cessation of smoking and loss of weight, two risk factors that are refractory to usual therapy. Fortunately, the authors found that regular participants experienced positive feedback, so dropout was not great and these desirable changes in life-style persisted. The high frequency of associated musculoskeletal injuries was disturbing. It would not be suprising if the actual incidence of these afflictions is even higher, since the group studied may have been able to persist in their running because their injuries were infrequent.
IMPROVED OUTCOMES WITH DRUG ELUTING VERSUS BARE METAL STENTS IN SAPHENOUS VEIN GRAFT INTERVENTION: A REPORT FROM THE EVALUATION OF DRUG-ELUTING STENTS AND ISCHEMIC EVENTS (EVENT) REGISTRY
Authors: Paul H. Tolerico, David J. Cohen, Neal S. Kleiman, Peter B. Berger, Emmanouil S. Brilakis, Robert N. Piana, Salim Shammo, Michelle J. Keyes, Kevin F. Kennedy, Joseph M. Massaro, Jorge F. Saucedo
Journal: Journal of the American College of Cardiology (2011)
NEONATAL MORTALITY ASSOCIATED WITH SYPHILIS AND OTHER MATERNAL INFECTIONS
Authors: ALFRED BAKER SPALDING
Journal: JAMA (1923)

My purpose is to estimate the relative incidence of various maternal infections associated with fetal death, and to discuss the possible utilization of such information to improve the routine care of pregnant patients in the prenatal clinic.  This report of our experience at Stanford is probably a fair presentation of what is being done in the average women's clinic to reduce fetal mortality. Also, as in similar institutions, our work is restricted and in many phases incomplete, owing to an inadequate budget.  About 1,000 new patients are treated each year in the Stanford Women's Clinic, with a total annual attendance that varies from 6,000 to 8,000 visits. The pregnant patients are segregated and given special care in the prenatal clinic. The clinic cooperates not only with the routine and special laboratories of the medical school, and with special departments, such as roentgenray and hydrotherapy, but also with the social service
Measures to reduce smoking in films should penalise film and tobacco industries
Authors: M. Males
Journal: BMJ (2002)

EDITOR—By looking at adolescents Sargent et al studied the effect that seeing tobacco use in films had on their trying smoking.1 So many issues are not accounted for in this study that to base sweeping legislative proposals on its findings would be unwise.

For one thing, the correlation that the authors found may operate in reverse (that is, teenage smokers are more likely than non-smokers to favour a variety of passive or thrill seeking behaviours, of which greater …
TCTAP A-177 The Impact of Metabolic Syndrome on Coronary Artery Spasm as Assessed with Intracoronary Acetylcholine Provocation Test
Authors: Se Yeon Choi, Seung-Woon Rha, Byoung Geol Choi, Yoonjee Park, Akkala Raghavender Goud, Hu Li, Sunki Lee, Ji Bak Kim, Sung Il Im, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2014)
Cellular DNA Content as a Predictor of Response to Chemotherapy in Infants with Unresectable Neuroblastoma
Authors: A T Look, F A Hayes, R Nitschke, N B McWilliams, A A Green
Journal: New England Journal of Medicine (1984)

We studied the relation between the DNA content of neuroblastoma cells and the response to therapy in 35 infants under one year of age with a diagnosis of neuroblastoma. Using flow cytometric techniques, we found that in 27 cases the primary malignant stem line consisted of neuroblasts with hyperdiploid DNA content, ranging from 1.07 to 2.42 times the finding in normal diploid cells. All remaining cases had diploid stem lines. Diploidy was more common in infants with clinical Stage D neuroblastoma (metastases beyond regional lymph nodes) than in those with other, less advanced stages: 6 of 10 as compared with 2 of 25 (P = 0.003). Of 17 evaluable patients with unresectable hyperdiploid tumors, 15 had complete responses and two had partial responses to cyclophosphamide and doxorubicin; six others with diploid tumors did not respond (P = 0.00001). We also found that each of the four infants with Evans' Stage IV-S neuroblastoma, an unusual form of disseminated neuroblastoma with a relatively good prognosis, had hyperdiploid tumor cells of clonal origin. We conclude that in neuroblastoma of infants, hyperdiploidy of tumor cells is associated with a better response to chemotherapy than is diploidy.