tbuckley/cabot-search huggingface dataset:
Ustekinumab Therapy for Severe Interstitial Granulomatous Dermatitis With Arthritis
Authors: Pauline Leloup, Hélène Aubert, Sylvie Causse, Benoît Le Goff, Sébastien Barbarot
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Issues in reporting epidemiological studies: No data are given to support generalisation
Authors: David F Blackburn
Journal: BMJ (2005)

Users' guide to detecting misleading claims in researchMisleading claims may be symptom of even more serious flaws Editor-Montori et al justifiably draw attention to misleading claims in published clinical trials. 1 This is a serious and common problem. 2 3 However, I object to their radical proposal that only the methods and results sections should be read, while the remainder of the paper should be ignored.The proposal is inconsistent with the title of their paper, "Users' guide to detecting misleading claims in clinical research reports." 1 How are these misleading claims to be identified if the sections containing them are omitted?Furthermore, anyone capable of critically appraising a trial solely on the basis of the methods and results is unlikely to be fooled by misleading claims in the discussion.But, more importantly, the proposal would deprive the discerning reader of witnessing the conflict between the results and the unwarranted conclusions.If researchers are willing to disseminate misleading claims then their integrity is brought into question.But if so, then all aspects of the trial-including the methods and results sections-are also brought into question.Misleading claims should be identified and broadcast loudly for they signal doubts about the entire study.Large scale randomised trials create the ideal conditions for data manipulation.Yet this is merely one of a multitude of problems stemming from a flawed method. 3 The remedy?When reading a study, ignore everything except the number of patients recruited.If this is large proceed no further as there is little prospect of encountering any data of genuine benefit to patients.
Platelet activation in patients with irritable bowel syndrome may reflect a subclinical inflammatory response
Authors: A Qasim
Journal: Gut (2003)

<i>Objectives</i>—To evaluate the hormonal response to strenuous endurance exercise performed by elite athletes. <i>Methods</i>—Nine professional cyclists (mean (SD) age 28 (1) years; mean (SD) Vo<sub>2</sub>max 75.3 (2.3) ml/kg/min) who participated in a three week tour race (Vuelta a España 1999) were selected as subjects. Morning urinary levels of 6-sulphatoxymelatonin (aMT6s) and morning serum levels of testosterone, follicle stimulating (FSH), luteinising hormone (LH), and cortisol were measured in each subject at t<sub>0</sub> (before the competition), t<sub>1</sub> (end of first week), t<sub>2</sub> (end of second week), and t<sub>3</sub> (end of third week). Urine samples of aMT6s were also evaluated in the evening at t<sub>0</sub>, t<sub>1</sub>, t<sub>2</sub>, and t<sub>3</sub>. <i>Results</i>—Mean urinary aMT6s levels had increased significantly (p&lt;0.01) during the day after each stage (1091 (33) <i>v</i> 683 (68) ng/ml at t<sub>1</sub>; 955 (19) <i>v</i> 473 (53) ng/ml at t<sub>2</sub>; 647 (61) <i>v</i> 337 (47) ng/ml at t<sub>3</sub>). Both morning and evening aMT6s levels decreased significantly during the study. A similar pattern was observed for morning serum levels of cortisol and testosterone. <i>Conclusions</i>—The results suggest that the basal activity of the pineal gland, adrenal glands, and testis may be decreased after consecutive days of intense, long term exercise.
&lt;emph type="ital"&gt;Double Portrait of Trudl&lt;/emph&gt;
Authors: M. Therese Southgate
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Great Influenza: The Epic Story of the Deadliest Plague in History
Authors: J. S. Oxford
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence and characteristics of disproportionate ventricular septal thickening in patients with coronary artery disease.
Authors: B J Maron, D D Savage, C E Clark, W L Henry, Z Vlodaver, J E Edwards, S E Epstein
Journal: Circulation (1978)

Echocardiographic or necropsy studies were performed in 151 patients with coronary artery disease. Prevalence of disproportionate septal thickening (septal to free wall ratio greater than or equal to 1.3) was 11%. An abnormally increased septal-free wall ratio in these patients had two principal etiologies. First, it was a manifestation of genetically transmitted hypertrophic cardiomyopathy, as evidenced by disproportionate septal thickening in first degree relatives. Second, it was due to disproportionate septal thickening which did not appear to be a manifestation of genetically transmitted hypertrophic cardiomyopathy. This latter conclusion was suggested by negative echocardiographic studies in some families of patients with both coronary artery disease and disproportionate septal thickening. In addition, numerous disorganized cardiac muscle cells, characteristically present in patients with genetically transmitted hypertrophic cardiomyopathy, were absent from the septum of all patients with disproportionate septal thickening studied at necropsy. Although the mechanism responsible for this secondary type of disproportionate septal thickening is unknown, our results indicate that the presence of disproportionate septal thickening in a patient with coronary artery disease does not, per se, indicate the coexistence of genetically transmitted hypertrophic cardiomyopathy.
The Excess Incidence of Diabetic End-Stage Renal Disease Among Blacks
Authors: Frederick L. Brancati, Jeffrey C. Whittle, Paul K. Whelton, Alexander J. Seidler, Michael J. Klag
Journal: JAMA (1992)

<h3>Objective.</h3> —To investigate whether the excess incidence of diabetic end-stage renal disease (ESRD) among African Americans could be explained by racial differences in putative ESRD risk factors. <h3>Design.</h3> —Population-based, ecologic study using the 1981 and 1982 Maryland Statewide Household Hypertension Survey for data on risk factor prevalence. <h3>Participants.</h3> —A total of 2.1 million adults residing within the boundaries of the Maryland Regional ESRD Registry, grouped by race and ZIP code into 26 subpopulations. <h3>Main Outcome Measure.</h3> —Incidence rates of treatment for diabetic ESRD between 1980 and 1985 from the Maryland Regional ESRD Registry by subpopulation. <h3>Results.</h3> —Between 1980 and 1985,442 persons entered treatment for diabetic ESRD. At the level of the subpopulation, diabetic ESRD incidence was positively associated with black race (relative risk [RR], 3.42; 95% confidence interval [CI], 2.84 to 4.13), prevalence of diabetes (RR, 2.35; 95% CI, 1.92 to 2.87), prevalence of poorly controlled hypertension (RR, 1.80; 95% Cl, 1.45 to 1.86), lack of a regular source of health care (RR, 1.82; 95% Cl, 1.62 to 2.05), and lower socioeconomic status as indicated by lack of college education (RR, 1.41; 95% CI, 1.32 to 1.52) (all,<i>P</i>&lt;.0001). After adjusting for these risk factors, black race remained strongly associated with the overall incidence of diabetic ESRD (RR, 2.70; 95% Cl, 1.89 to 3.86;<i>P</i>&lt;.0001). Further analyses suggested that this excess risk among blacks was confined to ESRD related to non—insulin-dependent diabetes (RR, 4.80; 95% Cl, 3.09 to 7.46;<i>P</i>&lt;.0001); blacks were at no higher risk than were whites for ESRD related to insulin-dependent diabetes (RR, 0.90; 95% CI, 0.52 to 1.55;<i>P</i>=.70). <h3>Conclusions.</h3> —These data suggest that the excess incidence of diabetic ESRD among blacks is not fully explained by a higher prevalence of diabetes or hypertension in blacks or by racial differences in age, socioeconomic status, or access to health care. Instead, they suggest an increased susceptibility to ESRD resulting from non—insulin-dependent diabetes among blacks as compared with whites. (<i>JAMA</i>. 1992;268:3079-3084)
USE OF METRAZOL IN THE TREATMENT OF ACUTE ALCOHOLISM
Authors: LEO L. ORENSTEIN, KARL M. BOWMAN, JULIA R. KAGAN, WALTER GOLDFARB
Journal: American Journal of Psychiatry (1939)

The problem of acute alcoholism in a large psychiatric service is considered. Metrazol was given intravenously in "subconvulsive" doses and found to be efficacious in the treatment of certain types of alcoholic intoxication. The result with metrazol in acute alcoholism is ascribed to the action of the drug as a direct stimulant of the central nervous system.
DIFFERENTIATING PACEMAKER-MEDIATED TACHYCARDIA FROM PACEMAKER ATRIAL TRACKING DURING WIDE COMPLEX TACHYCARDIA: UTILITY OF V-A-A-V VS. V-A-V RESPONSE AFTER PVARP EXTENSION
Authors: James Ip, Steven M. Markowitz, Christopher F. Liu, Jim W. Cheung, George Thomas
Journal: Journal of the American College of Cardiology (2011)
Reply from Authors re: Robert J. Hamilton, Gerald L. Andriole, Stephen J. Freedland. 5α-Reductase Inhibitors: Preventing the Treatable. Eur Urol 2012;62:242–4
Authors: J. Kellogg Parsons, Jeannette M. Schenk, Kathryn B. Arnold, Karen Messer, Cathee Till, Ian M. Thompson, Alan R. Kristal
Journal: European Urology (2012)
A SIMPLE OPERATION FOR THE RADICAL TREATMENT OF HEMORRHOIDS.
Authors: J. RAWSON PENNINGTON
Journal: JAMA (1901)

Hemorrhoids are usually described as bluish-red vascular tumors occurring in the thickened mucous membrane of the anus. They are generally considered to be varicose dilatations of the hemorrhoidal vessels, brought about by obstruction to the blood current and by chronic inflammatory processes. According to the investigations of Reinbach,<sup>1</sup>however, a hemorrhoid is a true angioma, whose development, which may begin in early childhood, depends on a new formation and cavernous metamorphosis of the blood vessels, and may be quite independent of any obstruction to the blood flow. As the pathology of hemorrhoids seems to be a more or less disputed question, and, since there is such a great variety of methods advocated for their treatment, which is probably due, in part at least, to the various conceptions of their pathology, I submitted to Dr. W. A. Evans specimens of these tumors for histologic and pathologic examination, hoping thereby to
Quantitative study of endocrine cells immunoreactive for calcitonin in the normal adult human lung.
Authors: J R Gosney, M C Sissons, J A O'Malley
Journal: Thorax (1985)

There was no significant variation in the numbers of bronchopulmonary endocrine cells immunoreactive for calcitonin in five pairs of adult human lungs either from case to case or between groups of anatomically equivalent lobes. This was the case whether their numbers were expressed in relation to epithelial length or to the total number of epithelial cells. The mean (SD) values for the frequency of occurrence of these cells in all 25 lobes studied were 4.3 (1.9) per 10 cm of epithelial length or 1.70 (0.78) per 10 000 epithelial cells. Most immunoreactive cells were single and situated in the airways; only three neuroepithelial bodies were observed, and no cells were present in the parenchyma examined. This study provides further evidence that the functional character of these cells may not be confined to early life.
Isozyme patterns in erythrocytes from human fetuses
Authors: Shi‐Han Chen, Jeanne E. Anderson, Eloise R. Giblett, George Stamatoyannopoulos
Journal: American Journal of Hematology (1977)

Abstract Starch gel electrophoretic patterns of 26 enzymes (corresponding to 36 gene loci) were examined in hemolysates of erythrocytes from 11 first‐trimester and midtrimester human fetuses (65‐138 gestation days). The zymograms of 16 enzymes were identical in fetal and control adult red cells. Six enzymes (enolase, guanylate kinase, lactate dehydrogenase, nucleoside Phosphorylase, phosphofructokinase, hexokinase) showed differences in the staining intensity of certain isozyme zones as compared with the controls. Also, the fetal red cell zymograms, in contrast to those of adults, contained the mitochondrial forms of isocitric dehydrogenase and glutamic oxaloacetic transaminase as well as more definite zones of phosphoglucomutase‐3. Finally, some of the isozymes of uridine diphosphate kinase in the fetal cells had slightly retarded mobility. These observed differences between fetal and adult red cells could reflect the expression of a different program of protein synthesis in red cells of the fetuses or the epigenetic modifications of isozymes in immature red cells.
Renal Dysfunction With Methoxyflurane
Authors: Franklin D. McDonald
Journal: JAMA (1971)

To the Editor.—  I read with considerable interest the article by Mazze et al entitled Renal Function Associated with Methoxyflurane Anesthesia ( 216 :278, 1971). Random, prospective studies such as this are what will be required to settle the question of the effect of methoxyflurane on renal function.  Unfortunately, I am unable to accept the explanation offered for the location in the nephron of the effect resulting from methoxyflurane. While inability to concentrate the urine in the presence of adequate amounts of antidiuretic hormone could be due to a distal convoluted tubule abnormality, it could also be due to failure of the sodium pump in the ascending limb of the loop of Henle, or to increased medullary blood flow. The former would prevent the establishment of, and the latter could wash out medullary hypertonicity. The way to distinguish distal tubule from loop dysfunction is to water load the patient. Those with
Peer review and NICE COPD guidelines
Authors: J A Wedzicha
Journal: Thorax (2004)

A further step in the process of developing better service and standards of care for patients with COPD T he full version of the new NICE guidelines on the management of chronic obstructive pulmonary disease (COPD) is published as a supplement to this issue of Thorax. 1 These guidelines have been developed for the National Institute for Clinical Excellence (NICE) by the National Collaborating Centre for Chronic Conditions (NCC-CC) based at the Royal College of Physicians, London with the involvement of
Reversibility of Atherosclerosis in Cholesterol-Fed Rabbits
Authors: WALTER M. BORTZ
Journal: Circulation Research (1968)

Previous studies have attempted to demonstrate the reversibility of rabbit atherosclerosis after discontinuance of cholesterol feeding or by other measures. These attempts have been largely unsuccessful. In all the studies, atherosclerosis was induced by cholesterol feeding for several months. At the end of these prolonged periods, the animals had advanced aortic lesions. The present study sought to determine whether a shorter exposure to an elevated blood cholesterol might produce lesions that were reversible. Rabbits were fed cholesterol until their serum levels reached at least 1000 mg/100 ml; cholesterol feeding was then discontinued. Serum cholesterol values rapidly returned to normal levels. Some were killed at the time of discontinuance of the cholesterol diet and the others at periods up to 300 days thereafter. The aortas were removed and analyzed chemically for cholesterol content. The results demonstrate that cholesterol feeding of short duration produces a significant lesion whose cholesterol content may decrease markedly some weeks after the serum cholesterol has returned to normal levels.
The Kennedy Autopsy
Authors: Frank M. Hilpert
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Under the WASHINGTON NEWS,The Journalreports, "Photographs and x-rays of the autopsy on the body of President Kennedy were turned over to the National Archives by his family" (<b>198</b>, Nov 21, 1966, adv p 36). This confirms numerous other reports which have recently appeared in the lay press. The original data, namely photographs and x-rays taken at the autopsy, were not in the hands of the government, but were in some manner given to the Kennedy family. This point demands clarification. Autopsy protocol, slides, tissues, documents, photographs, and x-rays, are by common understanding, the property of the hospital where the autopsy was completed. How, then, did the photographs and x-rays ever leave the files of the Bethesda Naval Medical Center? It is assumed that autopsy findings are always made available to the family upon request, and to those who have legal access to such findings. What
966. AAV Delivered Single-Chain Antibodies as Passive Immuno-Therapy for Prion Disease
Authors: Charles A. Wuertzer, Mark A. Sullivan, Howard J. Federoff
Journal: Molecular Therapy (2005)

Top of pageAbstract
Transmissible spongiform encephalopathies (TSE) are characterized by the conversion of a normal cellular protein (PrPc) to an abnormal disease causing conformation designated PrPsc. Efforts to use antibodies to alter the rate of conversion of PrPc to PrPsc suggest it to be a plausible therapeutic strategy. Notably, during the normal progression of disease the host organism mounts no detectable immune response to alter the process of PrPsc accumulation. This is hypothesized to be due to the low antigenicity of PrPc and host tolerance to a self-polypeptide. We intend to circumvent the lack of a host-based immune response to impede the conversion of PrPc using novel and previously characterized PrPc-specific single-chain variable fragment (scFv) antibodies that will be utilized in an AAV-based passive immuno-therapy. Several novel PrPc-specific antibodies have been obtained from a na|[iuml]|ve human combinatorial phage display library. Antibody D18 has been previously characterized with the ability to clear PrPsc from chronically infected cell-lines. Gross motor coordination of immunized challenged mice is being monitored by Rotarod performance. Data from ongoing evaluation of these vaccinated animals will be presented.
Acute Strychnine Poisoning after a Massive Dose
Authors: J. T. A. Lloyd, E. Pedley
Journal: BMJ (1953)

MEDICAL JOURNALremaining 3 cases we could obtain no information.Of the children who survived, 15 were entirely breast-fed 32 had been breast-fed for varying periods; 10 had never been breast-fed; of 6 we could get no history.Thirteen children developed poliomyelitis under the age of 6 weeks-6 died and 7 survived.Of the 7 survivors, 5 were entirely breast-fed, and, of these, 3 had a mild attack (category C).In the absence of a history of poliomyelitis in the mother.or knowledge of whether she had had an undiagnosed attack, we are unable to make any deductions of value from these figures.The following are the details of the six cases in which the mother also had poliomyelitis.Case 1. J. F. T.-The mother died of poliomyelitig six days after the baby was born.This baby died of poliomyelitis at the age of 10 days.Case 2. R. H. H.-The mother died of poliomyelitis on the fifth day of the puerperium.The child developed poliomyelitis at the age of 10 days and had a very severe attack (category A).Case 21. A. D. T.-The mother contracted an abortive attack of poliomyelitis at the same time as the child.The child-aged 9 weeks-contracted a serious attack of poliomyelitis (category A).Case 33. 0. H. G.-The mother contracted an abortive attack of poliomyelitis at the same time as the child.The child con- tracted poliomyelitis at the age of 13 weeks and had a serious attack.Case 39.S.F.-The mother had a severe attack of polio- myelitis seven days before the child.The child contracted polio- myelitis at the age of 15 weeks and had a mild attack.Case 51. A. B.-The mother had poliomyelitis two days before the baby.The child developed poliomyelitis at the age of !7 weeks and had a mild attack (category C).
Reply to Piet Ost, Alberto Bossi and Gert De Meerleer’s Letter to the Editor re: Michael L. Eisenberg, Benjamin J. Davies, Matthew R. Cooperberg, et al. Prognostic Implications of an Undetectable Ultrasensitive Prostate-Specific Antigen Level after Radical Prostatectomy. Eur Urol 2010;57:622–30
Authors: Michael L. Eisenberg, Benjamin J. Davies, Matthew R. Cooperberg, Janet E. Cowan, Peter R. Carroll
Journal: European Urology (2010)