Aerosolized Pentamidine and Pancreatitis
Authors: Catherine C. Hart
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 October 1989Aerosolized Pentamidine and PancreatitisCatherine C. Hart, MDCatherine C. Hart, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-8-691_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Aerosolized pentamidine is now widely used for prophylaxis ofPneumocystis cariniipneumonia in patients with the acquired immunodeficiency syndrome (AIDS). Aerosolized pentamidine is believed to have fewer side effects than are associated with either intravenous or intramuscular administration. The apparent safety of aerosolized pentamidine is thought to be due to low systemic levels of the drug (serum level < 10 ng/mL after aerosolized administration [1] compared with 209 ng/mL and 612 ng/mL after intramuscular and intravenous administration, respectively [2]. Pancreatitis has been reported with intravenous pentamidine therapy (3, 4) but to my knowledge has not been recognized...References1. Montgomery A, Debs R, and Luce J. Aerosolized pentamidine as sole therapy for Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. Lancet. 1987;2:480-3. CrossrefMedlineGoogle Scholar2. Conte J, Upton R, and Phelps R. Use of a specific and sensitive assay to determine pentamidine pharmacokinetics in patients with AIDS. J Infect Dis. 1986;154:923-9. CrossrefMedlineGoogle Scholar3. Salmeron S, Petitpretz P, and Katlama C. Pentamidine and pancreatitis [Letter]. Ann Intern Med. 1986;105:140-1. LinkGoogle Scholar4. Zuger A, Wolf B, and el-Sadr W. Pentamidine-associated fatal acute pancreatistis. JAMA. 1986;256:2383-5. CrossrefMedlineGoogle Scholar5. Karboski J and Godley P. Inhaled pentamidine and hypoglycemia [Letter]. Ann Intern Med. 1988;108:490. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Catherine C. Hart, MDAffiliations: New York Hospital-Cornell Medical Center New York, NY 10021 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrugs associated with drug-induced pancreatitis: focus on rarely discussed drugsDrug induced pancreatitis: A systematic review of case reports to determine potential drug associationsPANCREATITISDrug-Induced Hyperglycemia and Diabetes MellitusDrug-Induced Acute Pancreatitis: An Evidence-Based ReviewCare of the Adult Patient with HIV InfectionAcute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantationAcute pancreatitis in human immunodeficiency virus–infected patients: a reviewHuman immunodeficiency virus infection, Part IIDiabète sucré médicamenteux au cours de l'infection par le VIH. A propos de cinq casTHE PANCREAS IN AIDSHyperglycemia Induced by Megestrol Acetate in a Patient with AIDSPancreatic disorders in pediatric acquired immune deficiency syndromePancreatitis associated with aerosolised pentamidine.Non-infective Acute PancreatitisPancreatitis during Intravenous Pentamidine Therapy in an AIDS Patient with Prior Exposure to DidanosineHuman Immunodeficiency Virus Disease and Its ComplicationsInsulin-Requiring Diabetes Mellitus Associated with Pentamidine Therapy in a Patient with AIDSEndocrine Effects of HIV InfectionDidanosine Therapy in Patients Intolerant of or Failing Zidovudine TherapyHigh pentamidine levels associated with hypoglycemia and azotemia in a patient with Pneumocystis carinii pneumoniaAtteintes pancréatiques au cours du syndrome d'immunodéficience acquiseDiabetes after Aerosolized PentamidineJack P. Chen, MD, Robert L. Braham, MD, Kathleen E. Squires, MDDideoxyinosine in Children with Symptomatic Human Immunodeficiency Virus InfectionLa pneumocystose au cours de l'infection a HIV : Texte du consensusLes aerosols de pentamidine (AP) en prophylaxie primaire et secondaire de la pneumopathie a Pneumocystis carinii (PPC)2′,3′-Dideoxyinosine (ddI) in Patients with the Acquired Immunodeficiency Syndrome or AIDS-Related Complex 15 October 1989Volume 111, Issue 8Page: 691-691KeywordsAIDSDrug administrationDrug safetyDrugsPancreatitisPneumocystis carinii pneumoniaProphylaxisSafety ePublished: 1 December 2008 Issue Published: 15 October 1989 PDF downloadLoading ...