tbuckley/cabot-search huggingface dataset:
Microtubule-Mediated Defects in Junctophilin-2 Trafficking Contribute to Myocyte Transverse-Tubule Remodeling and Ca <sup>2+</sup> Handling Dysfunction in Heart Failure
Authors: Caimei Zhang, Biyi Chen, Ang Guo, Yanqi Zhu, Jordan D. Miller, Shan Gao, Can Yuan, William Kutschke, Kathy Zimmerman, Robert M. Weiss, Xander H. T. Wehrens, Jiang Hong, Frances L. Johnson, Luis F. Santana, Mark E. Anderson, Long-Sheng Song
Journal: Circulation (2014)

Background— Cardiac dysfunction in failing hearts of human patients and animal models is associated with both microtubule densification and transverse-tubule (T-tubule) remodeling. Our objective was to investigate whether microtubule densification contributes to T-tubule remodeling and excitation–contraction coupling dysfunction in heart disease. Methods and Results— In a mouse model of pressure overload–induced cardiomyopathy by transaortic banding, colchicine, a microtubule depolymerizer, significantly ameliorated T-tubule remodeling and cardiac dysfunction. In cultured cardiomyocytes, microtubule depolymerization with nocodazole or colchicine profoundly attenuated T-tubule impairment, whereas microtubule polymerization/stabilization with taxol accelerated T-tubule remodeling. In situ immunofluorescence of heart tissue sections demonstrated significant disorganization of junctophilin-2 (JP2), a protein that bridges the T-tubule and sarcoplasmic reticulum membranes, in transaortic banded hearts as well as in human failing hearts, whereas colchicine injection significantly preserved the distribution of JP2 in transaortic banded hearts. In isolated mouse cardiomyocytes, prolonged culture or treatment with taxol resulted in pronounced redistribution of JP2 from T-tubules to the peripheral plasma membrane, without changing total JP2 expression. Nocodazole treatment antagonized JP2 redistribution. Moreover, overexpression of a dominant-negative mutant of kinesin 1, a microtubule motor protein responsible for anterograde trafficking of proteins, protected against JP2 redistribution and T-tubule remodeling in culture. Finally, nocodazole treatment improved Ca 2+ handling in cultured myocytes by increasing the amplitude of Ca 2+ transients and reducing the frequency of Ca 2+ sparks. Conclusion— Our data identify a mechanistic link between microtubule densification and T-tubule remodeling and reveal microtubule-mediated JP2 redistribution as a novel mechanism for T-tubule disruption, loss of excitation–contraction coupling, and heart failure.
GENDER DIFFERENCES IN MORTALITY AMONG PATIENTS WITH SUPPLY-DEMAND TYPE 2 MYOCARDIAL INFARCTION, TYPE 1 MYOCARDIAL INFARCTION AND NON-MI CARDIAC TROPONIN I INCREASES
Authors: Yader Sandoval, Sarah Thordsen, Stephen Smith, MaryAnn M. Murakami, Karen Schulz, Fred Apple
Journal: Journal of the American College of Cardiology (2015)
(57) Parakeratosis pustulosa
Authors: D.A. Fenton, A. Goodfellow, P.D. Samman
Journal: British Journal of Dermatology (1985)

Journal Article (57) Parakeratosis pustulosa Get access D.A. Fenton, D.A. Fenton St John's Hospital for Diseases of the Skin, London WC2 Search for other works by this author on: Oxford Academic Google Scholar A. Goodfellow, A. Goodfellow Heatherwood Hospital, Berkshire Search for other works by this author on: Oxford Academic Google Scholar P.D. Samman P.D. Samman St John's Hospital for Diseases of the Skin, London WC2 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Page 103, https://doi.org/10.1111/j.1365-2133.1985.tb13072.x Published: 01 July 1985
Allergy and Immunology in Children
Authors: Richard Hong
Journal: JAMA (1974)

The editors' purpose was to put together in a readable volume, authoritative information on immunology and allergy, with a major emphasis on the practical application of basic information. For a busy practitioner, the first portion of the book provides a series of short state-of-the-art chapters on the development of immunity, immunodeficiency states, and autoimmune disorders. Although the section is fairly well done, in a field moving as rapidly as immunology it is difficult for current material to be included and many of the important modern concepts have been omitted, such as the role of cyclic nucleotides in lymphoid differentiation, subpopulations such as T helper and T suppressor cell, T- and B-cell distributions in peripheral blood lymphocytes and surface markers. The major portion of the text concerns allergic disease; however, insufficient emphasis is given to the controversial nature of the concepts presented. Thus, bacterial vaccines are recommended and one gets the
All sex differences in cognitive ability may be explained by an X-Y homologous gene determining degrees of cerebral asymmetry
Authors: T. J. Crow
Journal: Behavioral and Brain Sciences (1996)

Abstract Male superiority in mathematical ability (along with female superiority in verbal fluency) may reflect the operation of an X-Y homologous gene (the right-shift-factor) influencing the relative rates of development of the cerebral hemispheres. Alleles at the locus on the Y chromosome will be selected at a later mean age than alleles on the X, and only by females.
Lactic Acidosis in Dithiazanine Intoxication.
Authors: B. J. Matter
Journal: Annals of Internal Medicine (1967)

s1 May 1967Lactic Acidosis in Dithiazanine Intoxication.B. J. Matter, M.D. (Associate), H. Earl Ginn, M.D., Robert K. MercierB. J. Matter, M.D. (Associate)Search for more papers by this author, H. Earl Ginn, M.D.Search for more papers by this author, Robert K. MercierSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1060_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInterest in the metabolic events associated with dithiazanine iodide intoxication was stimulated by the observation of lactic acidosis in a patient who absorbed dithiazanine from the gastrointestinal tract. A measured plasma lactate of 36 mEq/liter and "excess lactate" (Huckabee) of 27 mEq/liter in this patient were corrected with methylene blue. Experimentally in dogs, a suspension of dithiazanine iodide in saline was given intravenously, and lactic acidosis was produced in all 11. A direct linear correlation was noted between the injected dose of dithiazanine in milligrams per kilogram of body weight and the maximum serum lactate response produced, between the dithiazanine... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: B. J. Matter, M.D. (Associate); H. Earl Ginn, M.D.; Robert K. MercierAffiliations: Nashville, Tennessee PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntestinal Parasites 1 May 1967Volume 66, Issue 5Page: 1060-1060KeywordsBlood plasmaBody weightGastrointestinal tractIntoxicationLactatesLactic acidosisMethylene blue ePublished: 1 December 2008 Issue Published: 1 May 1967 PDF downloadLoading ...
Using Proteinuria and Estimated Glomerular Filtration Rate to Classify Risk in Patients With Chronic Kidney Disease
Authors: Marcello Tonelli
Journal: Annals of Internal Medicine (2011)

Background: The staging system for chronic kidney disease relies almost exclusively on estimated glomerular filtration rate (eGFR), although proteinuria is also associated with adverse outcomes. Objective: To validate a 5-category system for risk stratification based on the combination of eGFR and proteinuria. Design: Retrospective cohort study. Setting: A provincial laboratory registry in Alberta, Canada, and a representative sample of noninstitutionalized U.S. adults. Patients: A derivation data set of 474 521 adult outpatients, 2 independent internal validation cohorts with 51 356 and 460 623 patients, and an external validation cohort of 14 358 patients. Measurements: Glomerular filtration rate, estimated by using the Modification of Diet in Renal Disease Study equation, and proteinuria, measured by using urine albumin-to-creatinine ratio or dipstick urinalysis. Outcomes included all-cause mortality and a composite renal outcome of kidney failure or doubling of serum creatinine level. Results: Over a median follow-up of 38 months in the internal validation cohorts, higher risk categories (indicating lower eGFR or more proteinuria) were associated with a graded increase in the risk for the composite renal outcome. The projected number of U.S. adults assigned to risk categories 3 and 4 in the alternate system was 3.9 million, compared with 16.3 million assigned to stage 3 and 4 in the current staging system. The alternate system was more likely to correctly reclassify persons who did not develop the renal outcome than those who did, although some persons developed the renal outcome despite reclassification to a lower category. However, all analyses of patients reclassified to a lower category showed that substantially fewer such patients developed the renal outcome than did not. Correct reclassification by the alternate system was more likely when proteinuria was measured by using albumin-to-creatinine ratio than with dipstick testing, and also more likely for the composite renal outcome than for mortality. Limitation: The study had a short follow-up time. Conclusion: Using proteinuria in combination with eGFR may reduce unnecessary referrals for care at the cost of not referring or delaying referral for some patients who go on to develop kidney failure. Primary Funding Source: Alberta Heritage Foundation for Medical Research interdisciplinary research team grant.
Survivin modulates genes with divergent molecular functions and regulates proliferation of hematopoietic stem cells through Evi-1
Authors: S Fukuda, J Hoggatt, P Singh, M Abe, J M Speth, P Hu, E M Conway, G Nucifora, S Yamaguchi, L M Pelus
Journal: Leukemia (2014)

The inhibitor of apoptosis protein Survivin regulates hematopoiesis, although its mechanisms of regulation of hematopoietic stem cells (HSCs) remain largely unknown. While investigating conditional Survivin deletion in mice, we found that Survivin was highly expressed in phenotypically defined HSCs, and Survivin deletion in mice resulted in significantly reduced total marrow HSCs and hematopoietic progenitor cells. Transcriptional analysis of Survivin−/− HSCs revealed altered expression of multiple genes not previously linked to Survivin activity. In particular, Survivin deletion significantly reduced expression of the Evi-1 transcription factor indispensable for HSC function, and the downstream Evi-1 target genes Gata2, Pbx1 and Sall2. The loss of HSCs following Survivin deletion and impaired long-term HSC repopulating function could be partially rescued by ectopic Evi-1 expression in Survivin −/− HSCs. These data demonstrate that Survivin partially regulates HSC function by modulating the Evi-1 transcription factor and its downstream targets and identify new genetic pathways in HSCs regulated by Survivin.
Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to imatinib mesylate
Authors: Xiaoyan Jiang, Donna Forrest, Franck Nicolini, Ali Turhan, Joelle Guilhot, Calvin Yip, Tessa Holyoake, Heather Jorgensen, Karen Lambie, Kyi Min Saw, Emily Pang, Ranko Vukovic, Paeta Lehn, Ashley Ringrose, Miao Yu, Ryan R. Brinkman, Clay Smith, Allen Eaves, Connie Eaves
Journal: Blood (2010)
Computers in Medicine
Authors: JOHN G. MAYNE
Journal: Annals of Internal Medicine (1969)

Editorials1 March 1969Computers in MedicineJOHN G. MAYNE, M.D., F.A.C.P.JOHN G. MAYNE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-3-641 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe potential benefits from the use of computers in handling medical information have been discussed with increasing frequency during the past 5 or 10 years. It has been obvious that our current system of information handling is inadequate. This inadequacy is due in part to a relative shortage of physicians and in part to the vast increase in the amount of medical knowledge flowing out of medical centers and laboratories.Physicians traditionally have sought ways to adapt technical advances to care for the sick. The new computer technology is enormously complex so that sophistication in scientific fields other than medicine... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Mayo Clinic Rochester, Minn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1969Volume 70, Issue 3Page: 641-642KeywordsComputersInformation technology Issue Published: 1 March 1969 PDF downloadLoading ...
Another Consequence of Uncontrolled Spread of HIV Among Adults: Vertical Transmission
Authors: Jody W. Zylke
Journal: JAMA (1991)

SOME mothers stitch baby blankets in celebration of their babies' birth. But the quilts adorning the walls at this conference were sewn to commemorate a child's death. Most children infected with the human immunodeficiency virus (HIV), such as those who are remembered in the panels from the NAMES (not an acronym) project displayed at the Sixth Annual National Pediatric AIDS Conference, at Washington, DC, were infected perinatally. The vertical transmission of HIV presents unique challenges to researchers and clinicians, yet its prevention ultimately depends on control of the disease in adults. <h3>Two Pediatric Patterns</h3> The route of transmission is obviously a major difference between the acquired immunodeficiency syndrome (AIDS) found in children and adults, but the clinical manifestations are different as well. Two patterns of disease occur in children. Some develop severe symptoms in the first year of life, such as wasting and encephalopathy.<i>Pneumocystis carinii</i>pneumonia is a major
Risk factors for stroke in middle aged British men.
Authors: A G Shaper, A N Phillips, S J Pocock, M Walker, P W Macfarlane
Journal: BMJ (1991)

To determine the risk factors for stroke in a cohort representative of middle aged British men.Prospective study of a cohort of men followed up for eight years.General practices in 24 towns in England, Wales, and Scotland (the British regional heart study).7735 men aged 40-59 at screening, selected at random from one general practice in each town.Fatal and non-fatal strokes.110 of the men had at least one stroke; there were four times as many non-fatal as fatal strokes. The relative risk of stroke was 12.1 in men who had high blood pressure (systolic blood pressure greater than or equal to 160 mm Hg) and were current smokers compared with normotensive, non-smoking men. Diastolic blood pressure yielded no additional information, and former cigarette smokers had the same risk as men who had never smoked. Heavy alcohol intake was associated with a relative risk of stroke of 3.8 in men without previously diagnosed cardiovascular disease. Men with pre-existing ischaemic heart disease had an increased risk of stroke, but only when left ventricular hypertrophy on electrocardiography was also present.Systolic blood pressure, cigarette smoking, and left ventricular hypertrophy on electrocardiography in men with pre-existing ischaemic heart disease were found to be the major risk factors for stroke in middle aged British men. Heavy alcohol intake seemed to increase the risk of stroke in men without previously diagnosed cardiovascular disease. A large proportion of strokes should be preventable by controlling blood pressure and stopping smoking.
A matter of (V segment) choice
Authors: Caitlin Sedwick
Journal: The Journal of Experimental Medicine (2008)

d > < d o c t o p i c > N e w s < / d o c t o p i c > Flushing out neutrophilsActivated neutrophils that infiltrate the liver during severe sepsis lodge themselves in the liver's tiniest blood vessels and cause organ damage.On page < a d d a r t t y p e = " r e l " d o i = " 1 0 . 1 0 8 4 / j e m . 2 0 0 7 1 7 6 5 " > 915< / a d d a r t > , McDonald et al. examine how neutrophils burrow into the liver and suggest a way to pry them out.Neutrophil recruitment in response to sepsis-triggering bacterial toxins such as LPS unfolds in several stages.In most places in the body, adhesion molecules called selectins initially snare neutrophils and help them tether to and roll along blood vessel walls.The cells subsequently adhere more firmly through integrins.But because neutrophils do not seem to need these molecules to stick to the blood capillaries in the liver, researchers suspected that the narrowness of these vessels instead physically traps the neutrophils.McDonald et al. now provide evidence against this entrapment model by showing that neutrophils are snagged by a different adhesion molecule, hyaluronan (HA), which they found at high levels in liver vessels.When mice were injected with LPS, neutrophil adhesion levels increased 14 fold, although HA levels did not change.The increased adhesiveness may be due to an HA-associated protein called SHAP, which increases HA's affinity for its neutrophil cell surface ligand, CD44.SHAP levels on the liver's capillary walls were increased by LPS treatments.Disrupting the interaction between CD44 and HA might potentially reverse sepsis; injecting LPS-treated mice with an anti-CD44 antibody rapidly detached neutrophils from the liver capillary walls and decreased liver damage.
Transforming Growth Factor β: Tumor Suppressor or Promoter? Are Host Immune Cells the Answer?
Authors: Li Yang, Harold L. Moses
Journal: Cancer Research (2008)

Abstract Therapies targeting transforming growth factor β (TGFβ) signaling using neutralizing antibodies and small molecular inhibitors are in multiple clinical trails. However, TGFβ is known to work as both a tumor suppressor and a tumor promoter, and current knowledge does not provide sufficient information on what factors mediate this switch in function and when this switch occurs. Recent advances in multiple disciplines suggest that immune cells from the tumor host may provide the answer. [Cancer Res 2008;68(22):9107–11]
Shared Idiotypes Expressed by Human B-Cell Lymphomas
Authors: Richard A. Miller, Sarah Hart, Michael Samoszuk, Christine Coulter, Sherri Brown, Debra Czerwinski, Janet Kelkenberg, Ivor Royston, Ronald Levy
Journal: New England Journal of Medicine (1989)

Each B-cell lymphoma expresses a surface immunoglobulin that contains unique antigenic determinants (idiotypes). We have produced 199 murine monoclonal antibodies reactive with the idiotypes isolated from 67 patients with follicular small-cleaved-cell lymphoma. These antiidiotype antibodies were analyzed for their ability to react with lymphoma cells from patients other than the one against which each antibody was made. Twenty of the 199 antiidiotype antibodies were reactive with lymphoma cells from more than one patient. Depending on the antibody, the frequency of idiotype sharing ranged from 0.6 to 6.2 percent of B-cell lymphoma tumors evaluated. Tumors could be grouped into distinct families on the basis of their reactivity with these antibodies. In the aggregate, the 20 antibodies reacted with a total of 49 of 150 B-cell lymphomas (33 percent), including 30 of 110 follicular small-cleaved-cell lymphomas (27 percent). Many of these shared idiotypes were expressed by more than one histopathological subtype of lymphoma. We conclude that a panel of antibodies reactive with shared idiotypes can be produced for patients with B-cell lymphoma, obviating the need to produce an antiidiotype antibody for each patient. (N Engl J Med 1989; 321: 851–7.)
Lenalidomide targets clonogenic side population in multiple myeloma: pathophysiologic and clinical implications
Authors: Jana Jakubikova, Sophia Adamia, Maria Kost-Alimova, Steffen Klippel, David Cervi, John F. Daley, Dana Cholujova, Sun-Young Kong, Merav Leiba, Simona Blotta, Melissa Ooi, Jake Delmore, Jacob Laubach, Paul G. Richardson, Jan Sedlak, Kenneth C. Anderson, Constantine S. Mitsiades
Journal: Blood (2011)
Prospective Comparison of Nasal Versus Oral Insertion of a Thin Video Endoscope in Healthy Volunteers
Authors: J.-F. Rey, D. Duforest, T. A. Marek
Journal: Endoscopy (1996)

Background and Study Aims: Attempts have been made to improve patients' tolerance of upper gastrointestinal endoscopy and to decrease the need for sedation, using thinner endoscopes and a nasal introduction route. We prospectively compared the oral and nasal routes in volunteers, using a thin prototype video endoscope.
Campaigning group accuses health department of "obfuscating" over health bill
Authors: Z. Kmietowicz
Journal: BMJ (2011)

The campaigning group 38 Degrees has accused the Department of Health for England of politicising genuine concerns it raised about the new Health and Social Care Bill, calling the government’s response to its legal opinion “obfuscating” and “muddled.”

The group, which says it takes action on issues that matter to the public, commissioned two barristers to analyse the health bill and published their analysis at the end of August ( BMJ 2011;343:d5525, doi:10.1136/bmj.d5525). The analysis said that the bill removes the obligation of the secretary of state for health to provide a national health service, instead handing over this responsibility to the new clinical commissioning groups. Stephen Cragg, a London barrister, said that this would effectively lead to “a fragmenting of a service that …