tbuckley/cabot-search huggingface dataset:
Radionuclide angiography in the diagnosis of congenital intrapericardial aneurysm of the left atrial appendage.
Authors: P J de Feyter, B S Zienkowicz, G A Heidendal, P A Majid, J P Roos
Journal: Thorax (1980)

The purpose of this communication is to emphasise the usefulness of radionuclide angiography in the diagnosis of a rare congenital anomaly of the left atrium which until recently could be detected only by contrast angiography or surgical exploration.Case report
The Smoking Puzzle: Information, Risk Perception, and Choice
Authors: J. M. Samet
Journal: JAMA (2004)

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In obesity and weight loss, all roads lead to the mighty macrophage
Authors: Alex Red Eagle, Ajay Chawla
Journal: Journal of Clinical Investigation (2010)

Obesity is associated with infiltration of white adipose tissue (WAT) by macrophages, which contributes to the development of insulin resistance. In this issue of the JCI, Kosteli and colleagues demonstrate that weight loss is unexpectedly also associated with rapid, albeit transient, recruitment of macrophages to WAT and that this appears to be related to lipolysis.
Ranolazine increases exercise performance and decreases hemoglobin A1C in angina patients with diabetes
Authors: Bernard R. Chaitman, Sandra Skettino, Carl J. Pepine, John O. Parker, Jaroslav Skopal, Galina Chumakova, Jerzy Kuch, Whedy Wang, Andrew A. Wolf
Journal: Journal of the American College of Cardiology (2003)
Abstract 2287: Tumors induce complex DNA damage in distant proliferative tissues <i>in vivo</i>
Authors: Christophe E. Redon, Jennifer S. Dickey, Asako J. Nakamura, Irina G. Kareva, Dieter Naf, Somaira Nowsheen, Peter K. Kalogerinis, William M. Bonner, Alexandros G. Georgakilas, Olga A. Sedelnikova
Journal: Cancer Research (2010)

Abstract The influence of a tumor on its surrounding tissues has been extensively investigated, but whether a tumor can influence distant tissues in an organism is unknown. This question is important in understanding the relationship between cancer and overall patient health. To explore this issue we chose to investigate the DNA damage endpoint, prompted by its utility in defining the “bystander effect” which denotes the phenomenon that cells exposed to ionizing radiation (or other stresses) communicate with their neighbors resulting in the appearance of DNA damage in unstressed cells. We measured DNA damage in tissues proximal and distal to the tumor site in C57BL/6 and BALB/c mice with early-stage subcutaneous syngeneic grafts, namely, B16 melanoma, MO5076 sarcoma, and COLON26 carcinoma. When the tumors approached 100 mg, the animals were sacrificed and various organs examined. Samples of duodenum, colon, rectum, stomach, liver, kidney, lung, ovary, skin, splenic and blood lymphocytes were taken for analysis. We report that levels of two types of DNA damage, double-strand breaks (DSBs) measured by γ-H2AX focus formation and oxidatively-induced non-DSB clustered DNA lesions (OCDLs), were elevated in tissues distant from the tumor site in the tumor-bearing mice compared to their age- and sex-matched controls. The most affected tissues were crypts in the gastrointestinal tract organs and the skin, particularly the hair follicles. These tissues have high rates of proliferation, indicating that S-phase cells were the most vulnerable to influence from the distant tumor. This study is the first direct demonstration of the tumor-induced bystander effect in vivo, i.e. that the presence of a tumor impacts distant tissues, and suggests that tumors may constitutively promote complex oxidative DNA damage in highly proliferating tissues throughout an organism. These findings may have important implications for the study of genomic instability resulting from a primary tumor as well as for understanding second cancers which are a growing concern as long-term survival after a first cancer increases. This study also suggests a role for DNA damage markers as general cancer-related stress biomarkers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2287.
TCT-500 Silent Occlusion, But Not Restenosis Without Occlusion After Primary Percutaneous Intervention Strongly Predicts Both Deterioration Of Cardiac Function And Future Clinical Events
Authors: Shinichiro Yamada, Hiroyuki Shibata, Yoshinori Yasaka, Akira Shimane, Seiichi Kobayashi, Tomofumi Takaya, Kiminobu Yokoi, Naoki Miyoshi, Shogo Oishi, Takayoshi Toba, Hachidai Takahashi, Takatoshi Hayashi
Journal: Journal of the American College of Cardiology (2012)
Brief lifestyle interventions for hypertension: Opportunity to provide useful information has been missed
Authors: Francesco P Cappuccio
Journal: BMJ (2004)

Editor-Despite research in tropical medicine being undertaken in countries from low human development index, authorship and editorial opinion remain with countries from higher development index.This unfair trend observed by Keiser et al demands to be addressed and overturned. 1 This observed bias may arise because countries of high human development index fund the bulk of research in tropical medicine. 2 3Authors from these countries have prepared the grant applications, taken principal investigator status, and believe that they should take primary or terminal authorship.Researchers from low human development index countries can break this cycle only if they can obtain international funding themselves or are allowed authorship by the principal investigators.It seems this is rarely extended to the collaborators in tropical countries, even though they are the ones practically conducting the study.If such generosity in authorship and mentorship were provided, this would enable researchers from low human devel-
Cutaneous Infection Due to Mycobacterium kansasii
Authors: James D. Maberry
Journal: JAMA (1965)

IN THE RECENT literature the atypical or unclassified mycobacteria have become more apparent. Pulmonary infections due to these organisms have been recognized which simulated tuberculosis. More recently, cutaneous lesions have been reported. This report was prompted by the observation of a primary cutaneous infection of some 22 years' duration caused by<i>Mycobacterium kansasii</i>. No similar cases due to this organism were found in a review of the literature. <h3>Report of a Case</h3> The patient is a 42-year-old white man, a rice farmer from the south Texas Gulf Coast. At the age of 11, while roller-skating on a concrete sidewalk, he sustained a 3inch laceration of the right knee which healed uneventfully. He frequently swam in the public swimming pool, but remembered no trauma related to this. He first developed a verrucose growth on his right knee in 1943, at the age of 21, while in military service. There had been
A fifth freedom?
Authors: D. Baird
Journal: BMJ (1965)

You will recollect that Franklin Roosevelt in a speech on 6 January 1941 said: " In the future days, which we seek to make secure, we look forward to a world founded upon four essential freedoms." The first is freedom of speech and expression." The second is freedom of every person to worship God in his own way."The third is freedom from want."The fourth is freedom from fear."And I would suggest that it is time to consider a fifth freedom freedom from the tyranny of excessive fertility.I propose to consider this problem first from the point of view of world population and secondly from the point of view of the individual man and woman.
462. Comparison of EMCV IRES and FMDV 2A Cleavage Factor for Expression of Canine MGMT and a Second Transgene Using HIV-1 Vectors
Authors: Srinivas N. Kumar, Tatiana Zaboikina, Michail Zaboikin, Friedrich G. Schuening
Journal: Molecular Therapy (2006)

We previously described the cloning and expression of canine methylguanine-DNA methyl transferase (MGMT) using monocistronic HIV-1 and gamma-retroviral vectors (Zaboikin M et. al. (2004) Hum Gene Ther 15:383-392). In that study, we showed that the canine MGMT was as efficient as the human MGMT for providing resistance to nitrosourea drugs such as BCNU. Here, we describe the creation and testing of dual-gene expression HIV-1 vectors encoding canine MGMT and EGFP under control of the EF1α promoter. The two genes were expressed either using encephalomyocarditis virus internal ribosome entry site (EMCV IRES) or the foot and mouth disease virus (FMDV) 2A cleavage factor. Vector stocks were prepared by transient transfection of 293T cells and used for infection of canine thyroid-adenocarcinoma cells. The cells were then subject to selection with O6-benzylguanine (BG) and BCNU. Flow cytometry of cells prior to and following drug selection indicated that both configurations of vector were able to provide drug resistance and allowed enrichment of transduced cells to greater than 84%. The expression of EGFP in the IRES containing vector (pN-EF1α-cMGMT-IRES-EGFP) was reduced compared to vector in which both transgenes were expressed using the FMDV 2A cleavage factor (pN-EF1α-cMGMT-2A-EGFP). These studies pave the way for utilizing canine MGMT encoding vectors for genetic correction in the dog model.
The Sketches of Erinensis: Selections of Irish Medical Satire 1824-1836
Authors: Charles G. Roland
Journal: JAMA (1980)

"Erinensis" was the pseudonym used by Peter Hennis Green, an Irish physician who wrote many columns for<i>The Lancet</i>from the 1820s to the 1840s. Following the iconoclastic lead of the editor, the gadfly Thomas Wakley, Green directed the full weight of his undoubted literary talent and mordant Irish wit to exposing the weaknesses and idiosyncrasies of the medical establishment in Dublin. Twenty of Green's columns have been resurrected here: a pastiche of biographical dissections (including Colles and Stokes), exposés of institutions (such as Steevens' Hospital), and some related miscellany. The implication of republication is, of course, that the material has contemporary interest sufficient to justify its reissue. What evidence is there that such is the case? Certainly Erinensis had the knack of turning a phrase. Of the increasing number of hospitals in Ireland, he wrote: "We have now every variety of hospital, from the wholesale house of recovery with
Sweat pore density on the fingertips of atopic patients
Authors: L.BACHMANN ANDERSEN, K. THESTRUP-PEDERSEN
Journal: British Journal of Dermatology (1987)

Investigation of 18 patients with atopic eczema and 22 normal controls showed that women in both groups had significantly more sweat pore openings on their fingertips than men and that there were more glands per unit area on fingers 3 and 4 compared with the thumb and the first and second fingers. There was no significant difference in the number of sweat pores between normal and atopic individuals, although fingertip topography in the latter was disturbed.
HAEMATOGENOUS INFECTION IN TRICHOPHYTIA
Authors: E. Bruusgaard
Journal: British Journal of Dermatology (1922)

CASES of trichophytia profunda (kerion Celsi) with severe symptoms of intlamniation are often accompanied by acute exanthemata of rying appearance, all of which, however, are closely connected i the primary focus.This is especially true in children.These exanthemata often spread rapidly over large areas of the surface of the skin and show a pronounced symmetry.'I'hc eruptions are accompanied hy generalised symptoms, more or less pronounced, such as fever, swelling of the lymph-glands and spleen, and more rarely joint affections.An exsinnniition of the blood reveals distinct leucocytosis.In the majority of cases the so-called lichen trichophyticus is found characterised by small perifollicular pale or deep red-coloured papules especially localised to the cliest and abdomeu.It may easily be mistaken for lichen scrofulosoruni.Sometimes eruptions are found which resemble measles and scarlet iever, and have very pronounced generalised symptoms.No less conspicuou.sare symmetrically arranged papules and nodes that in localisation and appearance bear a strong resemblance to the multiform erythema and erythema nodosnm.Various other clinical pic-tures are seen, but the above cited are the most important ones.*As a matter of fact these exanthemata have been observed bofore, but the possibility of their lieing due to tlu> primary trichophytia has not been considered.'I'his is quite natural.First, tbey are quite * In this eoiintry, where trichophytia profundn.is rather common, especially in tlie cattle-fiirniiiig diatnet, there is ample opportunity of studying the exanthematii.In former ai'tiuleB written for the Tidnsl-rift for den Norsl-e Lsegefovvnhig, 1M19, I have mentioned a conpte of cases of liclien ti'iehophyticiis.Since then we have had under treatment several different forms of the disease.Several [.laperB on this disease have also been published in Denmark, among others, see Rascli." Clinical Remarks on Trichophytia Pi'uf iinda (Kerion Ceisi)," British Journal of Dn-ituitologij and Syphiiis, 1920, and M. Brun Pedersen, Hogpitulslideiide, 1916, on the so-called lichenoid trichophytides.
Quality of reporting of randomised controlled trials - an analysis of the world congress of sports injury prevention in 2005 and 2008
Authors: K Knobloch, U Yoon
Journal: British Journal of Sports Medicine (2011)

Background Reporting quality of clinical trials has been addressed by the CONSORT group for randomised controlled trials (RCTs) first in 1996 with updates in 2001 and 2010. Objective We hypothesised that the quality of reporting in sports injury prevention abstracts has increased from 2005 to 2008 as did the amount of RCTs at the 1st versus 2nd World Congress of Sports Injury Prevention in Oslo vesus Tromsø. Design Analysis of the published abstracts of the 2005 and 2008 World Conference on Sports Injury Prevention, two independent analysts. Setting 154 abstracts from the 2005 and 186 abstracts from 2008 World Conferences were analysed. Main outcome measures Evidence-based study design, scores of 17 CONSORT criteria for RCT. Results RCTs were published in 9.1% in 2005 versus 10.2% in 2008 (p=0.727) of all published abstracts. Improvement in reporting was evident for RCTs in the CONSORT score 5.8±0.9 versus 8.6±2.9 (p=0.001, CI −4.29 to −1.43). Detailed description of main outcomes demonstrated the most significant improvement in reporting in the abstracts of RCTs (0% vs 57.9%, p&lt;0.001). Study design mentioned in the title, trial design, participants, blinding, number analysed, outcome and funding tended to but did not improve significantly in the reporting RCTs in conference abstracts. No improvement at all over the 3 years was noted for reporting quality of the title randomised, authors, intervention, objectives/hypothesis, randomisation, numbers randomised, recruitment, and number analysed, harms and trial registration. Conclusion While the percentage of published RCTs in abstracts at the World Congress of Sports Injury Prevention remained mainly unchanged, improvement in reporting of abstracts was evident from 2005 to 2008 determined by CONSORT criteria. Further substantial and comprehensive use of the recently updated CONSORT 2010 criteria might further increase the quality of reporting of sports injury conference RCTs in the future and should be endorsed.
EGFR-specific PEGylated immunoliposomes for active siRNA delivery in hepatocellular carcinoma
Authors: Jie Gao, Yongsheng Yu, Yingying Zhang, Jinjing Song, Huaiwen Chen, Wei Li, Weizhu Qian, Li Deng, Geng Kou, Jianming Chen, Yajun Guo
Journal: Biomaterials (2011)
Clinical and Prognostic Effect of a Positive Granulocyte Scan in Infective Endocarditis
Authors: U BORST, W BECKER, B MAISCH, W B??RNER, K KOCHSIEK
Journal: Clinical Nuclear Medicine (1993)

Thirty patients with clinical signs of infective endocarditis and pathologic echocardiographic findings indicating vegetations underwent scanning with ln-111 or Tc-99m hexamethylpropylene amineoxime (HMPAO) labeled granulocytes. Blood cultures were positive in 60% of the patients. The other cases were negative as a result of antibiotic pretreatment. The results of scintigraphy were correlated with the subsequent clinical course, and in 20 cases with data obtained by histologic examination of the valves. With regard to the degree of the inflammatory process, the nuclear medical procedure provided the following results: true-positive in 6 cases, false-positive in 1 case, true-negative in 19 cases, and false-negative in 3 cases. In this study, positive granulocyte scans correlate with high activity of the inflammatory process and predict a poor prognosis for the patients concerned.
Prevalence of autism in early 1970s may have been underestimated
Authors: H. Heussler, L. Polnay, E. Marder, P. Standen, C. Lyn U, N. Butler
Journal: BMJ (2001)

EDITOR—Recently, concerns about an apparent increase in the prevalence of autism in the general population, and the pathophysiology behind this, have been prominent in the press. Before these concerns can be addressed we need to be sure that the prevalence has truly increased. A cohort study was thought suitable to provide an insight into whether the prevalence of autistic disorders has increased.

In the British cohort 1970 study …
Food industry is under pressure to drop junk food advertisements
Authors: Rory Watson
Journal: BMJ (2005)

The European Commission is stepping up pressure on the food industry to phase out junkfood advertisements targeted at children as part of moves to reverse the growing trend ofobesity among young people.

Commission and industry representatives have been consulting over the past six months on the best ways to introduce some form of self regulation. But Markos Kyprianou, the new European Union health and consumer affairs commissioner, has warned that he will not hesitate to use legislation if the talks fail.

“My preference is for self regulation, which could involve all …
The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2
Authors: Baofeng Yang, Huixian Lin, Jiening Xiao, Yanjie Lu, Xiaobin Luo, Baoxin Li, Ying Zhang, Chaoqian Xu, Yunlong Bai, Huizhen Wang, Guohao Chen, Zhiguo Wang
Journal: Nature Medicine (2007)
Mechanisms of fluid cognition: Relational integration and inhibition
Authors: Indre V. Viskontas, Keith J. Holyoak
Journal: Behavioral and Brain Sciences (2006)

Blair argues that fluid cognition is dissociable from general intelligence. We suggest that a more complete understanding of this dissociation requires development of specific process models of the mechanisms underlying fluid cognition. Recent evidence indicates that relational integration and inhibitory control, both dependent on prefrontal cortex, are key component processes in tasks that require fluid cognition.
Transmission of Infection by Endoscopy
Authors: Alvin Markovitz
Journal: Annals of Internal Medicine (1993)

Letters1 September 1993Transmission of Infection by EndoscopyAlvin Markovitz, MDAlvin Markovitz, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-5-199309010-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their review, Spach and colleagues [1] stated that after a MEDLINE search from 1966 to 1992, they reviewed 265 articles on transmission of infection with endoscopy. They missed my article in the Western Journal of Medicine, a short report of an unusual organism transmitted in an unusual way [2].In 1974, a 20-year-old man had been in an automobile accident in Honolulu and had multiple fractures, including fractured ribs resulting in a pneumothorax. He had, among other procedures, a bronchoscopy with a rigid bronchoscope. He improved and was discharged, but 7 months after discharge, he was ...References1. Spach DH, Silverstein FE, Stamm WE. Transmission of infection by gastrointestinal endoscopy and bronchoscopy. Ann Intern Med. 1993; 118:117-28. Google Scholar2. Markovitz A. Inoculation by bronchoscopy (Letter). West J Med. 1979; 131:550. Google Scholar Author, Article, and Disclosure InformationAuthors: Alvin Markovitz, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1993Volume 119, Issue 5Page: 440-441KeywordsArmed forcesBronchoscopyEndoscopyMelioidosisPseudomonasRibs ePublished: 15 August 2000 Issue Published: 1 September 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Influence of Seeing the Patient First on Diagnostic Decision Making in Psychiatry
Authors: EUGENE F. GAURON, JOHN K. DICKINSON
Journal: American Journal of Psychiatry (1969)

With 18 psychiatrists as subjects, and utilizing filmed samples of patient behavior, the authors designed a study to investigate the relative importance of personal impression data versus life history information in arriving at a psychiatric diagnosis. Results indicated the importance of contact with the patient and further showed that psychiatrists deal comfortably and efficiently with personal impression information. However, the authors found that psychiatrists do not agree reliably on certain patient characteristics.