tbuckley/cabot-search huggingface dataset:
BLOOD INFECTION OF THE SUBMAXILLARY GLAND
Authors: W. Mercer
Journal: BMJ (1924)

AN acute suppurative inflammation of the salivary glands is in most cases an ascending infection from the duct, pre- disposed to by a diminished flow of the secretion2 by fever, and by a depressed general condition.So is it seen in m11ost post-operative abdominal cases.The colndition is usually classed as an ascending infection when there are obvious signs of the duct being the source-as, for example, a bright red protrusion of the duct mucosa or a strilng of cloudy mucus or pus exuding from the duct.In this type of case the primiary symptoms are those of recurrinig duct infectionis.A recent writer states that there is nio absolute proof that a blood-borne infection is ani occasional cause of acute suppurative inflammation of the salivary glands.The following case seems to be worth recording as most probably a blood-borne infection supervening on a duct obstruction iilflammation.J. S., aged 37, was wounded on September 14th, 1914, by a shell through the right elbow-joint.The joinit was shattered, and sinuses discharged for several years without intermission.In March, 1915, the wound healed, the joint having become ankylosed
ABSCESS OF THE CAeCUM, CONTAINING SOLID OPIUM, IN AN OPIUM-EATER
Authors: J. P. Bowling
Journal: BMJ (1853)

ptyalism; and MIr. A. excluded medicine altogether, and confined his treatment to the introduction of an elastic gum catheter into the aesophagus two or three times a week.Oa June 29th, the day after his return, I saw him.He had shrunk considerably; his step faltered; and his coun- tenance indicated great anxiety.There were cough, dys- pnia, and hoarseness, which he attributted to a cold-, caught a few days before, on a foggy day, in the suburbs of Lon- don; but which symptoms denoted, in fact, an extensiou of the disease, by proximity, from the wsophagus to the larynx.June :30th.I witnessedl an attempt to swallow a little milk.The effort caused an immiediate distension, or bulg- ing, just above the sternium, approximating in form and size to a small orangye.The dysphagia appeared very distress- ing.Atter several1 ineffectual attempts to force the mnilk through the stricture, it was at length regurgitated, a small portioni having passed, apparently guftftiiid.A gwlass, Col- ta-ining half a pint of mnilk, stood by hiim; he took ani ounce at oniec, and regurgitated each successive dratuighlt, until the glass was emllpty.The fluid was then imeasaured, andl it wa.sfound that fromi half an ounce to an ounce had passed into the stomach.The introduction of a flexible catheter was arrested just behind the clavicular enid of the sternum; by slight, manipulation, howvever, it passed its full length, eleven inlches.The operattioni was repeated on July 2nid, also on the 4th, 6th, 3th, 12th, 14th, and 16t'h, with little aiielioration in the dyspliagia, July 17th.The dysphagia was increased.Vesication over the tralchea was ordered.July 1tth.I introduce(d the bougie, and ordered a few minins of an antispasmodic tincture to be given in iiiucil- age occasionally ; anl ani anodyne liniment to be applied over the blistered surface.July 20th.The bougic was now introduced morning
Chemosuppression of Retinal Axon Growth by the Mouse Optic Chiasm
Authors: Li-Chong Wang, Rivka A Rachel, Riva C Marcus, Carol A Mason
Journal: Neuron (1996)

To determine whether diffusible guidance cues direct retinal axon growth and divergence at the optic chiasm, we cocultured mouse retinal and chiasm explants in collagen gels. The chiasm reduced retinal neurite lengths and numbers, but did not affect commissural or pontine neurite growth. This reduction in growth was equal for all retinal quadrants and occurred without reorienting the direction of neurite extension. The floor plate, another midline guidance locus, also suppressed retinal neurite outgrowth, whereas cortex or cerebellum explants did not. Growth suppression was not mediated by netrin-1, which instead enhanced retinal neurite extension. We propose that chemosuppression may be a general guidance mechanism that acts in intermediate targets to prime growth cones to perceive other, more specific cues.
Nonunion of the Shafts of the Long Bones
Authors: James L. ZumBrunnen
Journal: JAMA (1968)

A survey and an analysis of 140 nonunions of the shafts of long bones revealed that 104 (85%) of 123 surgically treated bones united when these four conditions were met: (1) accurate apposition of fragments, (2) adequate immobilization, (3) healthy soft tissue with sufficient blood supply surrounding the site of nonunion, and (4) stimulation of osteogenesis. Factors such as the type and extent of the original injury and initial treatment profoundly influenced the outcome of the nonunited fractures, but ultimate union depended upon restoration of the natural mechanisms of bone repair.
Specific IgE against Staphylococcus aureus enterotoxins: An independent risk factor for asthma
Authors: Claus Bachert, Kristel van Steen, Nan Zhang, Gabriele Holtappels, Tom Cattaert, Bärbel Maus, Roland Buhl, Christian Taube, Stephanie Korn, Marek Kowalski, Jean Bousquet, Peter Howarth
Journal: Journal of Allergy and Clinical Immunology (2012)
Noninvasive monitoring of orthotopic glioblastoma therapy response using RGD-conjugated iron oxide nanoparticles
Authors: Fan Zhang, Xinglu Huang, Lei Zhu, Ning Guo, Gang Niu, Magdalena Swierczewska, Seulki Lee, Hong Xu, Andrew Y. Wang, Khalid A. Mohamedali, Michael G. Rosenblum, Guangming Lu, Xiaoyuan Chen
Journal: Biomaterials (2012)
Emergency external fixators.
Authors: P. C. May
Journal: BMJ (1989)

it does contain records of day case hysterectomies and total hip replacements.We have passed Messrs Drife and Macafee's other observations on to the Office of Population Censuses and Surveys, who will no doubt appre- ciate their humour very much.After all, an error rate of about 1 in 1000 is far better than could have been expected in hospital discharge statistics and, though perhaps significant, is absolutely negligible -a distinction about which statisticians are ob- viously still failing to educate clinicians.
Proportions of Antigen and Antibody in Tests for Rh Antibodies
Authors: G. L. Taylor, R. R. Race, A. M. Prior, E. W. Ikin
Journal: BMJ (1942)

CLINICAL SIGNIFICANCE OF Rh FACTOR BRILjsH out of 48 cases the agglutinin was anti-Rh.In the remaining 4 cases it was either anti-A or anti-B.Because of this latter finding it is considered that the anti-A and the anti-B agglutinins are capable of qausing destruction of the infant's erythrocytes in a certain number of cases and thus, in some instances, of being the main causative factor of the erythroblastosis.The finding of weak Rh antibodies in the sera of the mothers of some babies with "physiological jaundice" supports the idea that there is no clear-cut distinction, from the clinical point of view, between mild and severe jaundice of the newborn.At the present time, if serological tests are used as an aid in the diagnosis of doubtful cases of erythroblastosis, com- patibility of the mother's serum with the infant's erythrocytes may be regarded as a strong point against the diagnosis, provided that the mother's serum is examined by a sensitive technique between 7 and 21 days after delivery.On the other hand, if the mother's erythrocytes are shown to be Rh-negative and her serum is found to contain anti-Rh agglutinins, the diagnosis is strongly supported.A change in the method of selection of blood donors in certain cases is urgently needed.This applies particularly in the case of transfusion of recently delivered women and, above all, whenever there is any suspicion that the present infant is affected with erythroblastosis or when there is any previous l history of the birth of jaundiced babies or of stillbirths without obvious cause.At the same time, a modification of the present method of testing for compatibility between the bloods of donor and recipient must be made.Methods for carrying out these tests are described, and compromise procedures are discussed for cases in which there are no facilities for making these tests.It is recommended that every blood bank takes steps to establish a panel of group 0 Rh-negative donors whose blood will be available, first, for the transfusion of the cases referred to above, and, secondly, for use as a routine in the transfusion of infants affected with erythroblastosis (when transfusion is required).We should like to thank the staff of the Hospital for Sick Children.Great Ormond Street, and the following medical officers, all of whom have given us much help by drawing our attention to cases and allowing us access to them, and in many instances by collecting samples and supplying very useful clinical
Coalition's NHS reorganisation is likely to increase fraud, report says
Authors: M. Limb
Journal: BMJ (2013)

A new think tank has drawn criticism over a report warning that the NHS in England risked losing more funds to fraud as contracting with the private sector expanded.

The Centre for Health and the Public Interest said that reorganisation of the NHS as a result of the Health and Social Care Act 2012 provided “significant opportunities” for fraudulent claims.

The centre, in its first report, published on 12 June, said that contracts with private …
Comparison of high pulse repetition frequency and continuous wave doppler echocardiography for velocity measurement and gradient prediction in children with valvular and congenital heart disease
Authors: A. Rebecca Snider, J. Geoffrey Stevenson, James W. French, Albert P. Rocchini, Macdonald Dick, Amnon Rosenthal, Dennis C. Crowley, Robert H. Beekman, Jane Peters
Journal: Journal of the American College of Cardiology (1986)
Cases of Perforating Ulcer of Stomach and of Intestine: With Remarks
Authors: Wm. Hinds
Journal: BMJ (1862)

recommended by Mr. Startin for the treatment of varicose ulcers; but I had used it before I was acquainted with his paper.Patients complain of the heat of the flannel rollers, but they gladly bear it in consequence of the great relief they soon obtain from its use.Domette partly obviates this objection.I have one other observa- tion to make: the roller must be accurately made, and in one piece.I get eight yards of domette, and have it washed.I then cut my rollers myself, measuring the width of each accurately with a rule.They should be two and a half inches wide.
Case 17-1974
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, William C. Moloney, John C. Long
Journal: New England Journal of Medicine (1974)

Presentation of Case First admission. A 25-year-old woman was admitted to the hospital because of anemia.She was well until three and a half years previously, when supraclavicular and cervical lymph nodes became enlarged, and she experienced fatigue, night sweats and fever. Biopsy of a right supraclavicular lymph node disclosed Hodgkin's disease, nodular-sclerosis type. A lymphangiographic study and a staging laparotomy revealed no infradiaphragmatic disease, and the stage of IIB was assigned. Radiation treatment was given, with a dose of 3500 rads to the cervical, supraclavicular and axillary regions, 3500 rads to the anterior mediastinum, 1000 rads to the . . .
Promoting children's home safety.
Authors: A F Colver, P J Hutchinson, E C Judson
Journal: BMJ (1982)

Home accidents are the main cause of death and morbidity in early childhood. Working-class children are at greatest risk. A study in an inner city area of the effects of a national television campaign about child accident prevention and of a locally designed health education initiative showed that 55% of families with young children in the study area did not watch any of the television programmes. Only 9% of a group specially encouraged to watch the programmes took any action to make their homes safer. In a comparable group who also received a home visit at which specific advice was given 60% took action to make their homes safer. The families studied were well aware before the television campaign of the importance and preventability of children9s accidents. The problems disadvantaged families face are therefore not ones of ignorance or apathy about hazards but practical difficulties in converting their concern into action. Administrative arrangements must be developed for providing health workers--especially health visitors--with detailed local information to pass on to parents.
UK's regulatory framework gives it an advantage in stem cell research
Authors: Christiane Rehwagen
Journal: BMJ (2005)

The United Kingdom is one of the best places in the world to do stem cell research, a research conference in London heard last week. Stephen Minger, the director of the stem cell biology laboratory at King's College London, was speaking at a conference on stem cell research organised by the Progress Educational Trust in London.

He explained, “This is because of the strong history in stem cell biology in the UK, the tight regulatory system administered by the Human Fertilisation and Embryology Authority (HFEA) and the strong commitment we have, both financially and politically, from the government.”

Simon Best, chairman elect of the …
Preeclampsia — Searching for the Cause
Authors: Caren G. Solomon, Ellen W. Seely
Journal: New England Journal of Medicine (2004)

Three to 5 percent of pregnancies in the United States are complicated by preeclampsia, a multisystem disorder characterized by hypertension and proteinuria that occurs after 20 weeks of pregnancy. Preeclampsia is associated with substantial risks. For the fetus, these include intrauterine growth restriction, death, and prematurity with attendant complications, whereas the mother is at risk for seizures (eclampsia), renal failure, pulmonary edema, stroke, and death. Despite considerable research, the cause or causes of preeclampsia remain unclear, and there are no clinically useful screening tests to identify women in whom it will develop. Antihypertensive therapy lowers maternal blood pressure but does . . .
Keratinocyte-derived, CD80-mediated costimulation is associated with hapten-specific IgE production during contact hypersensitivity to TH1 haptens
Authors: Robert Burns, Irina Luzina, Adnan Nasir, Constantine G. Haidaris, Richard K. Barth, Anthony A. Gaspari
Journal: Journal of Allergy and Clinical Immunology (2005)
Lessons from polyclinics in Central and Eastern Europe
Authors: B. Rechel, M. McKee
Journal: BMJ (2008)

<b>762</b> <h3><b>Objectives:</b></h3> PET with <sup>89</sup>Zirconium (<sup>89</sup>Zr) labeled monoclonal antibodies (mAbs) can be used for <i>in</i><i></i><i>vivo</i> quantification of antibody biodistribution and may improve prediction of efficacy and toxicity of mAb treatment. Knowledge about repeatability of these measurements is required to ensure correct interpretation, especially when assessing differences between antibody biodistributions. However, repeatability of <sup>89</sup>Zr-mAb PET is unknown, as radiation exposure is significant, thereby limiting test-retest studies. The aim of this study was to estimate the contribution of image reconstruction to the repeatability of tissue uptake of <sup>89</sup>Zr-mAb for quantification of antibody biodistribution. <h3><b>Methods:</b></h3> Three clinical <sup>89</sup>Zr-mAb PET datasets were included: <sup>89</sup>Zr-antiCD20 (1, 72, 144 h post injection (p.i.) of 74MBq, n=7), <sup>89</sup>Zr-cetuximab (1, 72, 144 h p.i. of 37MBq, n=7) and <sup>89</sup>Zr-antiCD44 (1, 24, 96 h p.i. of 37MBq, n=13). For all original images tissue volumes of interest (VOI) were defined. Manual delineation of complete organs (volume range 107-4377 mL) was used to obtain liver, spleen, lung, kidney and brain VOI. Fixed size VOI of 2.1 and 8.6 mL were placed in aortic arch and lumbar vertebrae to sample blood pool and bone marrow, respectively. Next, original PET list mode data were split before reconstruction, simulating test-retest scans. All VOI were applied to these test-retest scans. Mean activity concentrations (AC) were derived from these VOI. Repeatability was assessed using Bland-Altman plots (percentage difference versus mean activity concentration in Bq/mL, limits of agreement (LOA)), and repeatability coefficients (RC) were calculated (1.96xSD of the mean percentage difference). <h3><b>Results:</b></h3> Repeatability for all mAbs decreased with time. For <sup>89</sup>Zr-antiCD44 (18MBq), RCs were 8.0, 10.4 and 16.5% at 1, 24 and 96 h p.i., respectively. RCs for larger, manual VOIs were 7.2%, while RCs for smaller, fixed size VOIs were 28% at 96 h p.i. (Figure 1). For <sup>89</sup>Zr-antiCD20 (18MBq)/<sup>89</sup>Zr-cetuximab (18MBq), RCs for all VOIs were 13.7/9.9, 17.9/14.9 and 26.1/24.6% at 1, 72 and 144 h p.i., respectively. For a higher injected dose, repeatability improved. For 37MBq of <sup>89</sup>Zr-antiCD20, RCs were 8.2, 9.9 and 22.6% at 1, 72 and 144 hours p.i., respectively. <h3><b>Conclusion:</b></h3> For large, manually delineated tissue VOI a lower RC was obtained compared with smaller, fixed sized VOI. In general, RC of tissue uptake of <sup>89</sup>Zr-mAb was around 15 and 25% for imaging at 72 and 144 h p.i., respectively. Changes in biodistribution beyond this established range of repeatability are likely due to biological effects. <b>Research Support:</b> - $$graphic_7D3F9C3F-3A10-4459-AF40-D0C6909F7559$$
From the Congressional Office of Technology Assessment
Authors: D. Dougherty
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reporting Abuse of Competent Patients-Reply
Authors: Oscar W. Clarke
Journal: JAMA (1992)

<h3>In Reply.</h3> —In developing its guidelines on domestic violence, the Council on Ethical and Judicial Affairs considered the experience with mandatory reporting in the context of elder abuse. A number of experts oppose mandatory reporting for elder abuse. They observe that it can deter elder adults from seeking medical care and other necessary assistance. In addition, because states often do not provide sufficient funding for meaningful interventions, mandatory reporting may increase the risk of harm without offering any countervailing benefit.<sup>1</sup>As discussed by the Council in its report,<sup>2</sup>similar concerns apply when mentally competent, non—elder adults are abused by their spouses or other intimate partners. The Council also emphasized the importance of respecting the abused person's decision whether to accept an offered intervention or not. The Council Report recommends that physicians give assurances of safety and confidentiality and encourage their abused patients to consent to helpful interventions. Ultimately,
USE OF 4-DIMENSIONAL ECHOCARDIOGRAPHY IN THE MEASUREMENT OF RIGHT VENTRICULAR EJECTION FRACTION AND STROKE VOLUME: STUDIES IN A DYNAMIC IN VITRO MODEL
Authors: David J. Sahn, Weihui Shentu, Xiaokui Li, Minjuan Zheng, Pengyuan Zhang, Muhammad Ashraf
Journal: Journal of the American College of Cardiology (2012)
Innervation of human epicardial coronary veins: immunohistochemistry and vasomotility
Authors: O S. Opgaard, S Gulbenkian, A Bergdahl, C. Barroso, N C. Andrade, J. Polak, J Q. e Melo, L Edvinsson
Journal: Cardiovascular Research (1995)

Objective: The aim was to investigate the innervation and vasomotor responses to classical and putative transmitters of the coronary venous bed. Methods: The innervation of human epicardial coronary veins was investigated using acetylcholinesterase histochemistry and immunofluorescence staining, together with antisera against the general neuronal marker protein gene product 9.5 (PGP 9.5), the catecholamine synthesising enzyme tyrosine hydroxylase, and neuropeptides [neuropeptide Y, vasoactive intestinal peptide (VIP), substance P, and calcitonin gene related peptide (CGRP)]. The vasomotor responses to noradrenaline, acetylcholine, neuropeptide Y, substance P, human α calcitonin gene related peptide (αCGRP), and VIP were tested on isolated circular human epicardial coronary vein segments. Results: A network of nerve fibres was shown in the major epicardial coronary veins by means of an antiserum to PGP 9.5. The majority of the perivascular nerve fibres possessed neuropeptide Y and tyrosine hydroxylase immunoreactivity. Only a few nerve fibres displayed substance P, CGRP, and VIP immunoreactivity and acetylcholinesterase activity. Noradrenaline and acetylcholine induced powerful contractions of all the tested segments, whereas no contraction was induced by neuropeptide Y, αCGRP, substance P, or VIP. All segments precontracted with U46619 responded with potent relaxation to αCGRP, substance P, and VIP, whereas noradrenaline and acetylcholine only in low concentrations induced weak relaxation of a few of the segments. No relaxation was induced by neuropeptide Y. Conclusions: This is the first study to demonstrate comprehensively the perivascular innervation of human coronary veins and corresponding vasomotor effects, suggesting a role in regulation of the coronary venous circulation.
The efficacy of frequency specific microcurrent therapy on delayed onset hamstring muscle soreness
Authors: D Curtis, S Fallows, M Morris, C McMakin
Journal: British Journal of Sports Medicine (2011)

Introduction The effects of frequency specific microcurrent (FSM) therapy versus sham therapy in delayed onset muscle soreness (DOMS) was studied to determine whether specific frequencies on two channels would produce better results than single channel single frequency microcurrent therapy which has been shown to be ineffective as compared to sham in DOMS. Frequency specific therapy is thought to operate by the effects of both microamperage current and resonance on tissues and biochemical bonds. Methods 18 male and 17 female healthy participants (mean age 32 +/- 4.2 years) were recruited. Following a 15-minute treadmill warm-up and 5 sub-maximal eccentric muscle contractions, participants performed 5 sets of 15 maximal voluntary eccentric muscle contractions on a seated leg curl machine. Post-exercise, participants had one leg randomly assigned to a subsensory, silent treatment of 20 minutes of frequency specific microcurrent stimulation, while the other leg acted as non-treated control with the device turned off. (see figure 1) Participants were blinded to the treatment but the experimenter was not. Soreness was rated for each leg at baseline and at 24, 48 and 72 hours post exercise on a visual analogue scale (VAS), which ranged from 0 (no pain) to 10 (worst pain ever). Figure 31 Frequency specific microcurrent stimulation Results Both groups were identical at baseline ( p = 1.00). Post-exercise there was a significant difference ( p =0.0005) at 24 hours in the treated (1.3 / 10 ± 1.0) versus non-treated leg (5.2 / 10 ± 1.3). At 48 hours the treated leg was 1.2 / 10 ± 1.1 versus the non-treated of 7.0 / 10 ± 1.1 ( p = 0.0005). At 72 hours the treated group was 0.7 / 10 ± 0.6 and the non-treated was 4.0 /10 ± 1.6 ( p = 0.0005). Conclusion FSM therapy provided significant protection from DOMS at all time points tested.