Pathology of the Cardiac Conduction System in Thrombotic Thrombocytopenic Purpura
Authors: THOMAS N. JAMES
Journal: Annals of Internal Medicine (1966)

Article1 July 1966Pathology of the Cardiac Conduction System in Thrombotic Thrombocytopenic PurpuraTHOMAS N. JAMES, M.D., F.A.C.P., RAYMOND W. MONTO, M.D., F.A.C.P.THOMAS N. JAMES, M.D., F.A.C.P.Search for more papers by this author, RAYMOND W. MONTO, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-1-37 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThrombotic thrombocytopenic purpura is a fascinating uncommon hematologic disease that is becoming recognized with increasing frequency. Among its classical manifestations are various neurologic symptoms such as dizziness, syncope, and convulsions (1-8). These symptoms have been reported and observed with and without neurologic sequelae. Since thrombotic thrombocytopenic purpura is a diffuse disease involving virtually every organ in the body, and since focal lesions in the conduction system of the heart could give rise to syncope and other symptoms easily interpreted as neurologic in origin, we have undertaken a study of the sinus node, atrioventricular node, and His bundle in three patients...References1. BAEHRKLEMPERERSCHIFRIN GPA: An acute febrile anemia and thrombocytopenic purpura with diffuse platelet thrombosis of capillaries and arterioles. Trans. Ass. Amer. Physicians 51: 43, 1936. Google Scholar2. GORE I: Disseminated arteriolar and capillary platelet thrombosis. Amer. J. Path. 26: 155, 1950. MedlineGoogle Scholar3. LEVINESHEARN SMA: Thrombotic thrombocytopenic purpura and systemic lupus ery thematosus. Arch. Intern. Med. (Chicago) 113: 826, 1964. CrossrefMedlineGoogle Scholar4. MEACHAMORBISONHEINLESTEELESCHAEFER GCJLRWHJJA: Thrombotic thrombocytopenic purpura. Blood 6: 706, 1951. 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Med. 13: 3, 1952. CrossrefMedlineGoogle Scholar13. ENGELSCHEINKERHUMPHREY GLIMDC: Acute febrile anemia and thrombocytopenic purpura with vasothromboses. Ann. Intern. Med. 26: 919, 1947. LinkGoogle Scholar14. FITZGERALDAUERBACHFRAME PJOE: Thrombocytic acroangiothrombosis. Blood 2: 519, 1947. CrossrefMedlineGoogle Scholar15. GITLOWGOLDMARK SC: Generalized capillary and arteriolar thrombosis; report of two cases with a discussion of the literature. Ann. Intern. Med. 13: 1046, 1939. LinkGoogle Scholar16. LASZLOALVAREZFELDMAN MHAF: The association of thrombotic thrombocytopenic purpura and disseminated lupus erythematosus: report of a case. Ann. Intern. Med. 42: 1308, 1955. LinkGoogle Scholar17. JAMESRUPEMONTO TNCERW: Pathology of the cardiac conduction system in systemic lupus erythematosus. Ann. Intern. Med. 63: 402, 1965. LinkGoogle Scholar18. JAMES TN: Pericarditis and the sinus node. Arch. Intern. Med. (Chicago) 110: 305, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, MichiganFrom the Department of Medicine, Henry Ford Hospital, Detroit, Mich.This study was supported in part by grants from the Michigan Heart Association and grants H-5197 and H-7108, the U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Thomas N. James, M.D., Henry Ford Hospital, Detroit, Mich. 48202. 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RAPAPORT, M.D., F.A.C.P., JAMES MELTZER, M.D. 1 July 1966Volume 65, Issue 1Page: 37-43KeywordsCardiovascular therapyConvulsionsHeart diseasesHospital medicineLesionsLongitudinal studiesMedical servicesSyncopeThrombotic thrombocytopenic purpura Issue Published: 1 July 1966 PDF downloadLoading ...