tbuckley/cabot-search huggingface dataset:
Psychological therapy in the NHS
Authors: S. Wilson, P. Agulnik
Journal: BMJ (1991)

his life was not threatened.The eventual outcome -a mobile, two legged man-is far preferable to a disarticulated or hindquarter amputation.The hospital stay of seven months was a small price to pay for the patient's present state of health.The comments relating to the cost of his post- operative care are short sighted and obviously take no account of the patient's wishes, quality of life, and the long term cost to society of a young man with a mutilating amputation.
Hunterdon — May It Never Be Forgot!
Authors: Anne R. Somers
Journal: New England Journal of Medicine (1979)

The Camelot metaphor for the Hunterdon Medical Center is useful. Whether strictly applicable or not, it forces us to re-examine the experience of this unique hospital, which became the center of a community health-care system and which looked, for a brief period, as though it might emerge as a national prototype. Indeed, it did serve as a partial model for the American Hospital Association's short-lived "health care corporation" proposal.1 The "Hunterdon system" is far from becoming a national model, however; many of its essential elements were recently disavowed by its own medical staff, after a bitter struggle that attracted national . . .
TPM3/PDGFRB fusion transcript and its reciprocal in chronic eosinophilic leukemia
Authors: R Rosati, R La Starza, L Luciano, P Gorello, C Matteucci, V Pierini, S Romoli, B Crescenzi, B Rotoli, M F Martelli, F Pane, C Mecucci
Journal: Leukemia (2006)
Benefits and Risks of Solitary Islet Transplantation for Type 1 Diabetes Using Steroid-Sparing Immunosuppression
Authors: Boaz Hirshberg, Kristina I. Rother, Benigno J. Digon, Janet Lee, Jason L. Gaglia, Kenneth Hines, Elizabeth J. Read, Richard Chang, Bradford J. Wood, David M. Harlan
Journal: Diabetes Care (2003)

OBJECTIVE—The aim of this study was to describe the National Institutes of Health’s experience initiating an islet isolation and transplantation center, including descriptions of our first six recipients, and lessons learned. RESEARCH DESIGN AND METHODS—Six females with chronic type 1 diabetes, hypoglycemia unawareness, and no endogenous insulin secretion (undetectable serum C-peptide) were transplanted with allogenic islets procured from brain dead donors. To prevent islet rejection, patients received daclizumab, sirolimus, and tacrolimus. RESULTS—All patients noted less frequent and less severe hypoglycemia, and one-half were insulin independent at 1 year. Serum C-peptide persists in all but one patient (follow-up 17–22 months), indicating continued islet function. Two major procedure-related complications occurred: partial portal vein thrombosis and intra-abdominal hemorrhage. While we observed no cytomegalovirus infection or malignancy, recipients frequently developed transient mouth ulcers, diarrhea, edema, hypercholesterolemia, weight loss, myelosuppression, and other symptoms. Three patients discontinued immunosuppressive therapy: two because of intolerable toxicity (deteriorating kidney function and sirolimus-induced pneumonitis) while having evidence for continued islet function (one was insulin independent) and one because of gradually disappearing islet function. CONCLUSIONS—We established an islet isolation and transplantation program and achieved a 50% insulin-independence rate after at most two islet infusions. Our experience demonstrates that centers not previously engaged in islet transplantation can initiate a program, and our data and literature analysis support not only the promise of islet transplantation but also its remaining hurdles, which include the limited islet supply, procedure-associated complications, imperfect immunosuppressive regimens, suboptimal glycemia control, and loss of function over time.
Pancreatic Nesidioblastosis in Adults
Authors: Tse-Ling Fong, Nancy E Warner, Dinesh Kumar
Journal: Diabetes Care (1989)

Nesidioblastosis, a condition characterized by diffuse islet cell hyperplasia arising from the ductal epithelium, is often associated with hyperinsulinemic hypoglycemia. This is a childhood disease and is rarely found in adults. Only 10 histologically proven cases have been recorded, including 3 new cases described in this article. Most clinical and biochemical features are identical to those of an insulinoma, except the proinsulin-like component of circulating immunoreactive insulin, which is usually within the normal range in nesidioblastosis. Limited observations show that some patients may be managed medically with diazoxide. Patients who remain hypoglycemic despite medical therapy require pancreatectomy, although &amp;gt;90% resection frequently results in insulin dependency and permanent diabetes.
Carotid Atherosclerosis in Adolescents and Young Adults With IDDM: Relation to urinary endothelin, albumin, free cortisol, and other factors
Authors: Melpomeni Peppa-Patrikiou, Maria Scordili, Aristidis Antoniou, Maria Giannaki, Maria Dracopoulou, Catherine Dacou-Voutetakis
Journal: Diabetes Care (1998)

OBJECTIVE To investigate 1) alterations of carotid intimal-plus-medial thickness (IMT) in subjects with IDDM and 2) the relation of IMT to indexes of diabetic angiopathy and to risk factors of atherosclerosis. RESEARCH DESIGN AND METHODS IMT was assessed by ultrasound B-mode imaging in 39 subjects with IDDM (23 male, 16 female young adults aged 17.5 ± 5.2 years, diabetes duration 8.8 ± 5.9) and in 22 control subjects (healthy siblings of the IDDM subjects) of comparable age. Urinary endothelin (UET1) and urinary free cortisol (UFC) were determined by radioammunoassay (RIA), urinary albumin by nephelometry, HbA1c by high-performance liquid chromatography (HPLC), and plasma renin by immunoradiometric assay (IRMA). RESULTS The IMT values were greater in IDDM subjects than in control subjects (0.49 ± 0.1 mm, 0.44 ± 0.09 mm, respectively; P = 0.048) and greater in IDDM male subjects than in control male subjects (0.52 ± 0.09 and 0.44 ± 0.06 mm, respectively; P = 0.015), with no difference between IDDM and control female subjects. The IMT values were greater in diabetic male subjects than in female subjects (0.52 ± 0.09 and 0.45 ± 0.1 mm, respectively; P = 0.017). In IDDM subjects, but not in control subjects, there was a positive correlation of IMT to urinary albumin (P = 0.008), systolic blood pressure (P = 0.023), UET1 (P = 0.016), UFC (P = 0.002), and BMI (P = 0.021). Multiple regression analysis demonstrated that in IDDM subjects the variable that interacts independently with IMT was the BMI (P = 0.001). CONCLUSIONS IMT, an index of atherosclerosis (macroangiopathy), is increased in IDDM subjects quite early (already in adolescence), and it is positively related to urinary albumin, UET1, blood pressure, and UFC.
Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen.
Authors: F Rousset, E Garcia, J Banchereau
Journal: The Journal of Experimental Medicine (1991)

Human resting B lymphocytes enter a state of sustained proliferation when incubated with both mouse fibroblastic L cells stably expressing Fc gamma RII/CDw32 and anti-CD40 antibodies. We have explored the effects of 11 recombinant human cytokines (CKs) on induced cell proliferation and immunoglobulin (Ig) production. Interleukin 4 (IL-4) was the only CK able to enhance anti-CD40-induced B cell multiplication as measured by enumeration of viable cells, and interferon gamma (IFN-gamma) further stimulated this induced proliferation. IL-4 enhanced the production of IgM and IgG by B cells and induced them to produce IgE. Combinations of IL-4 and IL-2 resulted in the production of large amounts of IgM and IgA. Interestingly, IFN-gamma did not inhibit the production of IgE by cells stimulated with anti-CD40 and IL-4. None of the tested CK combinations resulted in the production of large quantities of IgG. Therefore, this new culture system represents a unique model to study isotype regulation in highly purified human B lymphocytes, in addition to allowing the generation of long-term factor-dependent human B cell lines.
German heart specialist received research grant from tobacco industry foundation
Authors: A. Tuffs
Journal: BMJ (2008)

The work of several leading German medical scientists has been sponsored by the International Philip Morris Research Foundation. Johannes Spatz, public health specialist and antitobacco activist in Berlin, made the discovery in a search of the internet archive of the tobacco company Philip Morris.

An official question by the Green Party in the Berlin Senate has publicly highlighted that the cardiologist Eckart Fleck, from the Berlin Heart Centre, had received a grant of €937 000 (£744 000; $1.28m) in 2003 to sponsor his work, analysis of the development of atherosclerosis, with the help of magnetic resonance imaging and histochemistry.

Professor Fleck …
Neonatal risk factors for cerebral palsy in very preterm babies: case-control study
Authors: D. J Murphy, P. L Hope, A. Johnson
Journal: BMJ (1997)

Objective: To identify neonatal risk factors for cerebral palsy among very preterm babies and in particular the associations independent of the coexistence of antenatal and intrapartum factors. Design: Case-control study. Setting: Oxford health region. Subjects: Singleton babies born between 1984 and 1990 at less than 32 weeks' gestation who survived to discharge from hospital: 59 with cerebral palsy and 234 randomly selected controls without cerebral palsy. Main outcome measures: Adverse neonatal factors expressed as odds ratios and 95% confidence intervals. Results: Factors associated with an increased risk of cerebral palsy after adjustment for gestational age and the presence of previously identified antenatal and intrapartum risk factors were patent ductus arteriosus (odds ratio 2.3; 95% confidence interval 1.2 to 4.5), hypotension (2.3; 1.3 to 4.7), blood transfusion (4.8; 2.5 to 9.3), prolonged ventilation (4.8; 2.5 to 9.0), pneumothorax (3.5; 1.6 to 7.6), sepsis (3.6; 1.8 to 7.4), hyponatraemia (7.9; 2.1 to 29.6) and total parenteral nutrition (5.5;2.8 to 10.5). Seizures were associated with an increased risk of cerebral palsy (10.0; 4.1 to 24.7), as were parenchymal damage (32; 12.4 to 84.4) and appreciable ventricular dilatation (5.4; 3.0 to 9.8) detected by cerebral ultrasound. Conclusion: A reduction in the rate of cerebral palsy in very preterm babies requires an integrated approach to management throughout the antenatal, intrapartum, and neonatal periods. #### Key messages
In patients with early rheumatoid arthritis, fish oil reduced failure of treatment with DMARDs
Authors: Michael Denman
Journal: Annals of Internal Medicine (2014)

Source Citation Proudman SM, James MJ, Spargo LD, et al. Fish oil in recent onset rheumatoid arthritis: a randomised, double-blind controlled trial within algorithm-based drug use. Ann Rheum Dis. 2013: Sep 30. [Epub ahead of print] 24081439
Abstract 5263: An RNAi screen of the protein kinome identifies <i>CHEK1</i> as a therapeutic target in neuroblastoma
Authors: Kristina A. Cole, Jonathan Huggins, Michael Laquaglia, Sharon Diskin, Edward F. Attiyeh, Chase Hulderman, Miryung Han, Kristopher Bosse, Jayanti Jagannathan, Yael P. Mosse, Patrick Mayes, John M. Maris
Journal: Cancer Research (2010)

Abstract Background High-risk neuroblastoma is a pediatric cancer that is often fatal despite intense multimodality therapy associated with significant late effects for those who survive. Therefore, patients will benefit from treatment strategies that rationally exploit signaling pathways for which a tumor cell is selectively dependent. In an effort to identify novel therapeutic targets, we performed a comprehensive loss of function screen of the protein kinome in neuroblastoma cell models. Methods Using a validated siRNA library which targets the human protein kinome, we transiently transfected individual kinase siRNAs into four neuroblastoma cell lines and measured substrate adherent growth. We then ranked the top 100 most potent kinase siRNAs per cell line and integrated the lists to identify kinases with inhibition in multiple lines. Results Thirty targets emerged as potent in at least three of the four neuroblastoma cell lines. They were enriched for kinases involved in the cell cycle and mitosis. This select group was tested with an independent set of more specific siRNA pools in an expanded panel of eight neuroblastoma cell lines. The strikingly most potent to emerge from the secondary screen was the cell cycle checkpoint kinase CHEK1. CHEK1 knockdown appeared cytotoxic, often by 24 hours, coinciding with complete CHEK1 protein knockdown and an emergence of a substantial apoptotic fraction. As further validation of the siRNA results, pharmacologic inhibition with SB21807, a relatively specific CHEK1 inhibitor, showed cytotoxicity in 7 of 8 neuroblastoma cell lines with a median IC50 of 430 nM (range 62-677 nM), while the non-neuroblastoma lines RPE-1, DOAY and MCF7 cells were resistant with a median IC50 of 2609 nM (1066 - 2898 nM). The mechanism of selective inhibition in neuroblastoma is unclear as we did not identify mutations in the coding exons of CHEK1. Western blotting revealed, however, that CHEK1 is constitutively phosphorylated at the Ser 296 residue in 8/8 neuroblastoma cell lines and 10/16 primary tumors samples, but not in controls. Conclusion We have identified CHEK1 as a potential therapeutic target in neuroblastoma and are currently extending our work to understand the mechanism of this tumor's apparent selective sensitivity to CHEK1 inhibition. As CHEK1 inhibitors are currently in phase I/II clinical trials as chemosensitizers, we are also focused on determining the in vivo efficacy of combination CHEK1 inhibition with chemotherapy in neuroblastoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5263.
Co58B12 ABSORPTION, PLASMA TRANSPORT AND EXCRETION IN PATIENTS WITH MYELOPROLIFERATIVE DISORDERS, SOLID TUMORS AND NON-NEOPLASTIC DISEASES*
Authors: I. Bernard Weinstein, Donald M. Watkin
Journal: Journal of Clinical Investigation (1960)

Several investigators have documented the fact that chronic myelocytic leukemia (CML) is as- sociated with increases in serum vitamin B12 concentrations which may be of the order of 20 to 40 times the normal value (1-4).Less striking and less consistent elevations have been found in other myeloproliferative disorders.These include acute myelocytic leukemia (1, 3, 4), myeloid metaplasia (2-4), polycythemia vera associated with mye- locytic leukemia (4) and Di Guglielmo's disease (5).Elevations have also been reported in pa- tients with solid tumors when there are metastases to the liver (3, 6).The present study was de- signed to investigate in vivo the role that gastro- intestinal absorption, plasma transport and renal excretion of vitamin B12 play in producing this abnormality.Previous in vivo studies have dealt with the fate of a large intravenously administered dose of ra- (lioactive B1, (7, 8).In the present studies a dose of approximately 0.5 ug of Co58B12 was chosen, since this is within the limits of the estimated daily requirement of B12 (9).Oral administration was used so that gastrointestinal absorption could be evaluated and a physiologic pattern of plasma concentrations and excretion could be obtained.Twenty-four subjects have been studied, six of whom had CML. MATERIALS AND METHODSMaterials.Co58B12 1 had an original specific activity of 3.0 Atc per jig.The biologic activity of the material used
LABEL BORIC ACID SOLUTIONS POISON
Authors: William D. McNally
Journal: JAMA (1933)

To the Editor:  —The recent deaths of three infants by the accidental use of boric acid in a New York Hospital recalls six similar accidents in a Chicago hospital in 1927 (McNally, W. D., and Rust, C. A.: The Distribution of Boric Acid in Human Organs in Six Deaths Due to Boric Acid Poisoning,The Journal, Feb. 4, 1928, p. 382). All these accidents occurred as the result of administering a solution of boric acid for water or saline solutions. The use of boric acid and its salts in the medical profession and in some of the economic lay industries has made them commonplace—so much so, in fact, that their power for harm through overdosage or accidental consumption has receded to the background until ordinary precaution, at times, is not used in administering these substances. The potential danger of boric acid poisoning is sufficiently great to make it imperative that
Improved Metabolic Risk Markers Following Two 6-Month Physical Activity Programs Among Socioeconomic Marginalized Women of Native American Ancestry in Lima, Peru
Authors: Folke Lindgärde, Bo Ahrén
Journal: Diabetes Care (2007)

It is known that ethnicity is a risk factor for diabetes. Thus, individuals of African, Latin American, and Asian descent are particularly susceptible (1). As an example, a health survey in six urban areas in Peru found a diabetes prevalence of 17% among women (2,3). It was also found that low socioeconomic status was associated with a high burden of noncommunicable diseases and appeared as an independent risk factor for diabetes. In several populations, it is known that increased physical activity reduces the risk for diabetes (4,5). Whether this applies for all populations is, however, not known. The aim of the present study was to explore if supervised endurance training is feasible among socioeconomically marginalized women of a poor urban area in Lima, Peru.

The study population consisted of 142 Amerindian women. They were all examined in 1999 (6) and had a normal fasting plasma glucose concentration (range 2.8–5.6 mmol/l). Five years later, a total of 83 women participated in a follow-up examination (7). Of these, 76 consented to take part in the present training study. Mean age was 41 years (range 25–64 years). The women were randomly assigned into group A (one training session per week) or group B (three training sessions per week). No economic compensation was given besides free athlete suits …
Doctors seem not to be punished for dishonesty in their cv
Authors: P. Wilmshurst
Journal: BMJ (2001)

EDITOR—Minerva reports that one in three men and one in five women lied in their curriculum vitae.1 Anybody who has sat on an appointments committee will be aware that candidates often exaggerate. Part of this is self deception, but genuine dishonesty occurs too. One doctor claimed on his curriculum vitae to be the author of publications by another doctor who had the same surname and the same initial of his first name.

A candidate for the post of …
Osteopathic manipulation resulting in damage to spinal cord.
Authors: C Davis
Journal: BMJ (1985)

In case 2, apart from a stiff neck, the patient had no clear neurological symptoms, though neurological examination may have resulted in findings consistent with cervical myelopathy.After manipulation by an osteopath, registered with the British Society of Osteopathy, the patient developed severe neurological problems.In the two other cases there were pre-existing neurological symptoms, and manipulation was undertaken by respectable on 20 August
SENSORY DEPRIVATION UNDER NULL-GRAVITY CONDITIONS
Authors: GEORGE W. BARNARD, HAROLD D. WOLFF, DUANE E. GRAVELINE
Journal: American Journal of Psychiatry (1962)

In evaluating the results of this series of experiments it should be noted that we did not obtain our desired level of minimal external sensory stimulation. We do believe, however, that we did obtain a significant degree of sensory deprivation and attenuation. Although there are trends in reactions to sensory deprivation, it remains evident that the situation will be viewed differently by various subjects. Each subject will react to the situation in accordance with his past experience and personality structure. While intellectual and emotional changes were present in our Air Force group, the degree of alterations were not as great as in some of the previously reported experimental groups. It may be that the defense mechanisms of our group did not permit as much loss of reality contact as other experimental subjects, most of whom were college students or other non-Air Force groups. An alternate explanation might be that we were introducing so much external stimulation in the nature of physical discomfort that subjects focused on this and prevented the lapse into primary process thinking with true hallucinations. By using new facilities and techniques, our future research well determine if further lowering of sensory input causes a greater loss of contact with reality. There was a suggestion that those who remained in the deprivation environment for the 10 hours were able to relate the somatic discomforts with detachment and had confidence in themselves, in the monitors and in the equipment.
Prothrombin Complex Concentrates and Coagulation
Authors: JOHN A. PENNER
Journal: Annals of Internal Medicine (1976)

Comments1 October 1976Prothrombin Complex Concentrates and CoagulationJOHN A. PENNER, M.D.JOHN A. PENNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-4-531 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I write with reference to "Intravascular Coagulation With Use of Human Prothrombin Complex Concentrates," the paper by Cederbaum, Blatt, and Roberts in the June issue (Ann Intern Med84:683-687, 1976). Although I quite agree with Dr. Cederbaum and co-authors' conclusions that the prothrombin complex product should not be used in nonhemophilic patients when therapeutic alternatives are available, the doses administered to the patients cited in their paper were considerably higher than what is ordinarily recommended by the manufacturer for replacement therapy in hemophilia. The doses described are similar to those used to initiate disseminated intravascular coagulation in...References1. HEDNERNILSSONBERGENTZ UIS: Various prothrombin complex concentrates and their effect on coagulation and fibrinolysis in vivo. Thromb Haemostasis 35:386-395, 1976 CrossrefMedlineGoogle Scholar2. GREENDYMOCKPOLLER GIL: Use of factor-VII rich prothrombin complex concentrate in liver disease. Lancet 1:1311-1314, 1975 CrossrefMedlineGoogle Scholar3. PENNER J: Activated prothrombin complex concentrates in congenital and acquired hemorrhagic disorders. Semin Thromb Hemostasis, 1976, in press Google Scholar1. BLATTLUNDBLADKINGDON PRH: Thrombogenic materials in prothrombin complex concentrates. Ann Intern Med 81:766-770, 1974 LinkGoogle Scholar2. KINGDONLUNDBLADVELTKAMP HRJ: Potential thrombogenic materials in Factor IX concentrates. Thromb Diath Haemorrh 33:617-631, 1975 MedlineGoogle Scholar3. GUILLINMÉNACHÉBARGE MDJ: Les troubles de l'hémostase au cours des hépatites virales graves: éetude clinique, anatomique et biologique. Ann Med Interne (Paris) 122:605-615, 1972 Google Scholar4. CEDERBAUMBLATTROBERTS APH: Intravascular coagulation with use of human prothrombin complex concentrates. Ann Intern Med 84:683-687, 1976 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN A. PENNER, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe use of recombinant factor VIIa in the treatment of bleeding disorders 1 October 1976Volume 85, Issue 4Page: 531-532KeywordsDisseminated intravascular coagulationHemophilia ePublished: 1 December 2008 Issue Published: 1 October 1976 PDF downloadLoading ...