tbuckley/cabot-search huggingface dataset:
Psychiatric problems after mastectomy
Authors: H G Kinnell
Journal: BMJ (1978)

ultrasonography is non-invasive, safe, and reasonably cheap.The results can be very accurate.In a recent prospective study of 124 patients' there were no false-normal reports.Ultrasound correctly identified all 33 patients with chronic pancreatic disease and correctly classified them as suffering from cancer or pancreatitis.There were four false-positive reports.No doubt the results of ultrasonograpny and isotope scanning are both subject to the individual operator's expertise and experience.The crucial question for any promising diagnostic method is whether or not it is "exportable"-whether the same results can be obtained in less committed hands.The answer for isotope scanning is already clear; for ultra- sonography we must wait a little longer.
Physical work capacity and lung function in competitive swimmers.
Authors: E. E. McKay, R. W. Braund, R. J. Chalmers, C. S. Williams
Journal: British Journal of Sports Medicine (1983)

Competitive swimmers require a high aerobic capacity to support the sustained performance of severe exercise. Maximal oxygen uptake values and blood lactate concentrations were measured in ten male and fifteen female swimmers from the Scottish National and Youth Squads 1981-82. Lung function tests were also performed to determine pulmonary efficiency. The results of these studies were compared with other investigations of international competitive swimmers and indicate a high level of fitness among Scottish national swimmers.
Pleuropneumonia-like Organisms in Genital Infections
Authors: E. Klieneberger-Nobel
Journal: BMJ (1959)

BiRffmi 19MEDICA,L JOURNiAL case of a patient who took large doses of phenolphthalein, aloin, and podophyllum for 20 years and developed ileocolitis in many respects similar to that in Case 1. Heilbrun's patient and one other (Jewell and -Kline, 1954) showedradiological evidence of improvement of the colon when the purges were reduced or stopped.However, it is most unlikely that the severe colitis in Case 1 would have healed even if it had been possible to stop the purges.Further, aloin was taken by Case 3 for 40 years without colitis arising; and, again, the two patients reported by Schwartz and Relman (1953) also took irritant purges with resultant severe.loss of potassium but did not develop signs of colitis.In Case 2, when the purge was reduced the procto- sigmoiditis disappeared, and here it is conceivable that the purge was the cause of the bowel changes.Summary Three cases are described in which chronic purgation caused excessive loss of sodium, potassium, and water in the faeces and gave rise to electrolyte-deficiency states.These disturbances were studied by chemical and radioisotope methods.The manner in which these losses were brought about is discussed and the inadequate knowledge of the action of common purges on the intestine noted.The evidence in these cases suggested that " irritant " purges may exert an action on the small intestine.This work was done in collaboration with Dr. M. Lubran.who was responsible for the laboratory investigations and who is publishing elsewhere (Lubran, 1959) an account of the methods used, with results in normal controls.We are grateful to Mr. J. Scholefield for referring these patients to us and for his help and co-operation in the studies undertaken in Case 1.We also thank Miss E. R. Harrison, lately senior dietitian at the hospital, for the diet histories;
Left Atrial Myxoma: Echocardiographic Diagnosis and Determination of Size
Authors: Abdulla M. Abdulla
Journal: JAMA (1977)

SINCE its initial clinical recognition by cineangiography in 1951,<sup>1</sup>several cases of left atrial myxoma have been reported, and echocardiography has rapidly established itself as a reliable, relatively inexpensive, and safe noninvasive technique for the diagnosis of left atrial tumors. We treated a patient with atrial fibrillation, no heart murmurs, and recurrent syncope in whom the diagnosis of left atrial tumor and an accurate estimate of its size were made by echocardiography. The diagnosis was confirmed by cineangiocardiography, and subsequent surgical excision of the myxoma was accomplished. <h3>Report of a Case</h3> A 68-year-old man was admitted to Eugene Talmadge Memorial Hospital for prostatectomy. Cardiology consultation was sought because of recent onset of atrial fibrillation and a 15-year history of recurrent syncope (one to five per month), the first episode of which followed an accidental head injury. These syncopal episodes were not associated with convulsions or any signs or symptoms
P17.81 * TREATMENT AND SURVIVAL OF ELDERLY GLIOBLASTOMA PATIENTS IN SLOVENIA 1999 - 2013
Authors: U. Smrdel
Journal: Neuro-Oncology (2014)

Glioblastoma is the most common primary brain tumor. It peaks its incidence in the seventh decade. In recent years we are observing a steady rise in the number of glioblastoma patients in their 70s and 80s. We do not know the optimal treatment for these patients. In our database we searched for patients older than 70 years and are reporting treatment characteristics and outcome. From the 1999 to 2013, 799 patients with glioblastoma were treated at the Institute of Oncology Ljubljana. Of those 151 patients were 70 years or more. While in the first five years of observation period, there were 9% of patients over 70, there were rise to 22% afterwards. In these periods we also observed a modest rise of number of all glioblastoma patients, which at first we attributed to the rise of diagnosing elderly patients, but as this might be true for the initial rise, we then had to concede, that later this is only partly true and that diagnosing extremely frail patient is the other contributing factor. As we analyzed survival of our patients, we observed a steady rise of survival for patients under 70 (from 9 months 1999-2003 to 13 months 2009-2013), but unchanged survival of elderly (5,3 months and 5,4 months respectively). While the fraction of patients receiving gross total resection or maximal reduction remains same throughout the period, the fraction of patients receiving radiotherapy and temozolomide has risen, this failed to leave any impact on prognosis of elderly patients. In the last period however, we have scaled down the treatment intensity, effectively treating more patients with pure palliative intent (mostly radiotherapy 30 to 35 Gy in 6 to 10 fractions in 2 weeks), and there was no discernible difference in survival compared to conventional fractionation. Omitting systemic therapy likewise produced no worsening in survival. Patients treated with palliative intent had significantly less hematological toxicities, their performance status deteriorated less during treatment and required less interventions. Contrary to other glioblastoma patients, in elderly patients, there is no improvement in survival with more intensive treatment and single modality treatment is equally effective as any other. Any more intensive treatment in elderly should be reserved for those most fit and if possible within a trial.
Recurrent dislocation of the extensor carpi ulnaris tendon.
Authors: G Inoue, Y Tamura
Journal: British Journal of Sports Medicine (1998)

Five patients with recurrent dislocation of the extensor carpi ulnaris (ECU) tendon resulting from an athletic injury were treated by reconstruction of the ECU tendon sheath, and each had a satisfactory result. Two types of disruption of the fibro-osseous sheath were found. In two cases in which the fibro-osseous sheath ruptured radially, the torn sheath lay on its ulnar groove beneath the ECU tendon. These patients were treated by direct suture of the sheath over the ECU tendon. In three cases in which the fibro-osseous sheath ruptured ulnarly, the torn sheath lay superficial to the ECU tendon. These patients were treated by reconstruction of the sheath using a piece of the extensor retinaculum. We believe that surgical reconstruction of the fibro-oseous sheath of the ECU tendon should be considered for symptomatic dislocation of the ECU tendon, even in an acute case.
Renal uptake of an 18-mer phosphorothioate oligonucleotide
Authors: Rainer Oberbauer, George F. Schreiner, Timothy W. Meyer
Journal: Kidney International (1995)

Renal uptake of a 35S labeled 18-mer phosphorothioate oligodeoxynucleotide (molecular wt approximately 6,000) was evaluated following intravenous infusion into rats. The kidneys contained 21 +/- 3% of the infused dose at five hours after infusion and 3 +/- 1% of the infused dose at four days after infusion. The concentration of oligonucleotide was greater in the kidney than in the liver, spleen, or plasma at both intervals. Urine excretion of oligonucleotide label averaged 17 +/- 1%, 35 +/- 5%, and 64 +/- 3% of the infused dose at five hours, one day, and four days after infusion. Electrophoresis (PAGE) showed that oligonucleotide was retained in the kidney was the intact 18-mer at both five hours and four days after infusion, while full size oligonucleotide was not found in the urine at either interval. Light microscopic autoradiography showed that oligonucleotide uptake was most prominent in the early proximal tubule. Electron microscopic autoradiography indicated that oligonucleotide was not confined to the brush border or endocytic-lysosomal pathway. Micropuncture studies showed that the tubule fluid to plasma concentration ratios of oligonucleotide label averaged 7 +/- 3% in Bowman's space and 6 +/- 2% in the distal tubule. Despite restriction of filtration by plasma protein binding, as indicated by the low Bowman's space to plasma concentration ratio, the calculated tubular reabsorption rate for oligonucleotide was sufficient to account for the large amount of oligonucleotide found in the kidney after intravenous infusion. These results indicate that the proximal tubule plays a prominent role in the disposition of intravenously infused oligonucleotide, and raise the possibility that oligonucleotides could exert antisense effects in this nephron segment.
A transcriptome atlas of rice cell types uncovers cellular, functional and developmental hierarchies
Authors: Yuling Jiao, S Lori Tausta, Neeru Gandotra, Ning Sun, Tie Liu, Nicole K Clay, Teresa Ceserani, Meiqin Chen, Ligeng Ma, Matthew Holford, Hui-yong Zhang, Hongyu Zhao, Xing-Wang Deng, Timothy Nelson
Journal: Nature Genetics (2009)
Journal of Psychotherapy Practice and Research
Authors: Clark D. Terrell
Journal: JAMA (1993)

The<i>Journal of Psychotherapy Practice and Research</i>, now in its second year of publication, states as its aim "to address the professional understanding of human behavior and to enhance the psychotherapeutic treatment of mental disorders." In the inaugural issue, the editors further define the journal's goals: to "enhance our appreciation of the conduct of psychotherapy by addressing clinical concerns reflected by single case or small sample reports, as well as by publishing important research initiatives that attempt to deepen our understanding of how different psychotherapies work, and for whom, by studying larger groups of patients." As well as regular articles, the journal has published special articles, clinical and research reports, grand rounds case presentations, reprints of classic articles, editorial commentaries, and book reviews. Fairly diverse topics are covered, including clinical applications of theoretically derived hypotheses, studies of technical interventions, psychotherapeutic approaches to treatment of specific disorders, and others. A few
Dual-factor triggered fluorogenic nanoprobe for ultrahigh contrast and subdiffraction fluorescence imaging
Authors: Zhe Wang, Xiaoxiang Zhang, Peng Huang, Weidong Zhao, Dingbin Liu, Liming Nie, Xuyi Yue, Shouju Wang, Ying Ma, Dale Kiesewetter, Gang Niu, Xiaoyuan Chen
Journal: Biomaterials (2013)
434 HBV-specific CD8+ cells for preventing relapse after lamivudine therapy on patients with chronic B viral hepatitis
Authors: C.K. Lee, K.H. Han, J.H. Suh, Y.S. Cho, S.Y. Won, S.H. Ahn, C.Y. Chon, Y.M. Moon, I.S. Park
Journal: Journal of Hepatology (2004)
How common are renal angiomyolipomas in patients with pulmonary lymphangiomyomatosis?
Authors: M L Blute
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

"How common are renal angiomyolipomas in patients with pulmonary lymphangiomyomatosis?." American journal of respiratory and critical care medicine, 154(5), pp. 1580–1581
Optimal Timing for Use of Glycoprotein IIb/IIIa Inhibitors in Acute Coronary Syndromes
Authors: Kenneth W. Mahaffey, Robert A. Harrington
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Thought for Your Pennies
Authors: Thomas Jefferson
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Novel Evolutionarily Conserved Element Is a General Transcriptional Repressor of p21WAF1/CIP1
Authors: Weiguo Xu, Qi Zhu, Zhenghua Wu, Hao Guo, Fengjuan Wu, Dhahiri S. Mashausi, Chengjie Zheng, Dawei Li
Journal: Cancer Research (2012)

Abstract The effective induction of p21WAF1/CIP1/Cdkn1a (p21) expression in p53-negative cancer cells is an important avenue in cancer management. We investigated the ability of various common chemotherapeutic drugs to induce p21 expression in p53-negative cancer cells and showed that the induction of p21 expression by oxaliplatin is caused by the derepression of a previously unrecognized negative regulatory element with a Sp1/Sp3 palindrome sequence core at −216 to −236 of the p21 proximal promoter. Electrophoretic mobility shift and antibody super-shift assays confirmed the specific binding of Sp1/Sp3, and showed that the oxaliplatin-mediated derepression of p21 transcription was associated with an increased Sp1/Sp3 phosphorylation and binding affinity to the oxaliplatin-responsive element. A search of the ENCODE database for vertebrate-conserved genomic elements identified the Sp1/Sp3 palindrome element as the only vertebrate-conserved element within the 500-bp proximal p21 promoter region, indicating its fundamental importance. In in vivo competition assays, transfected synthetic Sp1/Sp3 palindrome elements derepressed the cotransfected or endogenous p21 promoter in a dosage-dependent manner. This derepression was not seen in oxaliplatin-treated cells, suggesting that the exogenous Sp1/Sp3 palindrome and oxaliplatin had the same downstream signaling target. Taken together, our results revealed, for the first time, this evolutionarily conserved Sp1/Sp3 palindrome element in the proximal p21 promoter that serves as a regulatory repressor to maintain p21 basal level expression. Cancer Res; 72(23); 6236–46. ©2012 AACR.
Sex and Gender Bias in Illustrations in Anatomy and Physical Diagnosis Texts
Authors: Tarek Arja
Journal: JAMA (1995)

To the Editor.  —Ms Mendelsohn and colleagues 1 did a nice job of documenting, classifying, and statistically interpreting a large number of anatomical illustrations for this work. However, the authors have not demonstrated any scientific significance to their work, believing, I suspect, that the significance is self-evident. I am writing to say that it is not.  The authors make several unsupported and probably unproveable statements in an attempt to justify this study, such as: This underrepresentation of women in anatomy texts may prevent students from becoming as familiar with the female body as they are with the male body and may create the perception that the male body is 'normal' and the female body 'abnormal.' The authors also have some rather grandiose ideas regarding the impact of their study as can be seen in their last sentence: Overcoming text bias could contribute to improving women's health and help bring about
SOME CAUSES OF POOR FUNCTIONAL RESULTS FOLLOWING PROSTATECTOMY
Authors: ROBERT H. HERBST
Journal: JAMA (1926)

The paramount issue in the problem of benign prostatic obstruction is not simply the removal of the enlarged gland, but the correction of urinary function to as near the point of perfection as possible. In order to obtain this result, it is frequently necessary to do more than the enucleation of the adenoma. There are a number of factors that play a part in poor function following prostatectomy, the correction of which, before or at the time of the removal of the gland, would help to minimize these not uncommon results. Some of these conditions are due to omissions in the preoperative study, while others may be avoided by careful attention to detail during removal of the gland. <h3>DIVERTICULA OF THE BLADDER</h3> Diverticula of the bladder are not uncommonly associated with prostatic obstruction and play an important rôle in its symptomatology. In fact, they may have more to do with
Pregnancy and abortion in women with essential thrombocythemia
Authors: Anna Candoni, Renato Fanin, Teresa Michelutti, Domenico Russo, Angela Michelutti
Journal: American Journal of Hematology (2002)

To the Editor: Chronic lymphocytic leukemia was diagnosed in a 63year-old female patient in May 1991.Peripheral blood smears showed increased leucocytes (18,500/ll) with up to 90% lymphocytes positive for CD 19 (97%) and CD 5 (52%).Bone marrow involvement was 80%.Initial CT scans showed multiple lymphomas at different regions enlarged up to 2 cm.Thrombocytes were slightly decreased to 127,000/ll and hemoglobin was normal with 14.3 g/dl.Treatment with chlorambucil (6 mg/m 2 p.o.; days 1À3) and prednisone (75 mg/day p.o. day 1, 50 mg/day p.o. day 2, 25 mg/day p.o. day 3) repeated every 2 weeks was initiated between December 1993 and September 1994 and between June 1996 and April 1997.In October 1998 the patient developed progressive disease with 88% lymphocytes in the peripheral blood smears, 90% bone marrow in®ltration, multiple abdominal lymphomas enlarged up to 4 cm, progressive splenomegaly and, in addition autoimmune hemolytic anemia (AIHA).Repeated treatment with chlorambucil and prednisone yielded no response.In February 1999 irradiation of the spleen (8 Gy) was initiated because of massive splenic enlargement (30 cm).During radiation therapy a dramatic aggravation of hemolysis developed.Laboratory data were: leucocytes 6,500/ll, platelets 57,000/ll, hemoglobin 5.7 g/dl, bilirubin 6.0 mg/dl, indirect bilirubin 4.9 mg/dl, haptoglobin <0.05 g/l, lactate dehydrogenase (LDH) 378 U/l.The direct Coombs test was strongly positive.Steroid dosage was increased to 40 mg dexamethasone per day for 4 days followed by 50 mg prednisone/ day.This high-dose steroid treatment initially resulted in a slight improvement of hemoglobin, but reduction of the steroid medication led to renewed aggravation of hemolysis.Also three cycles of chemotherapy with cyclophosphamide (750 mg/m 2 i.v.every 4 weeks) did
A Novel Dietary Triterpene Lupeol Induces Fas-Mediated Apoptotic Death of Androgen-Sensitive Prostate Cancer Cells and Inhibits Tumor Growth in a Xenograft Model
Authors: Mohammad Saleem, Mee-Hyang Kweon, Jung-Mi Yun, Vaqar Mustafa Adhami, Naghma Khan, Deeba N. Syed, Hasan Mukhtar
Journal: Cancer Research (2005)

Abstract In prostate cancer, a fine balance between cell proliferation and apoptotic death is lost, resulting in increased cellular mass and tumor progression. One approach to redress this imbalance and control this malignancy is its preventive intervention through the use of dietary natural agents. Here, we investigated the growth-inhibitory effect and associated mechanisms of Lupeol, a triterpene present in fruits and vegetables, in androgen-sensitive human prostate cancer cells. Lupeol treatment resulted in significant inhibition of cell viability in a dose-dependent manner and caused apoptotic death of prostate cancer cells. Lupeol was found to induce the cleavage of poly(ADP-ribose) polymerase protein and degradation of acinus protein with a significant increase in the expression of FADD protein. Among all death receptor targets examined, Lupeol specifically caused a significant increase in the expression of Fas receptor. The small interfering RNA–mediated silencing of the Fas gene and inhibition of caspase-6, caspase-8, and caspase-9 by their specific inhibitors confirmed that Lupeol specifically activates the Fas receptor–mediated apoptotic pathway in androgen-sensitive prostate cancer cells. The treatment of cells with a combination of anti-Fas monoclonal antibody and Lupeol resulted in higher cell death compared with the additive effect of the two compounds alone, suggesting a synergistic effect. Lupeol treatment resulted in a significant inhibition in growth of tumors with concomitant reduction in prostate-specific antigen secretion in athymic nude mice implanted with CWR22Rν1 cells. Because early clinical prostate cancer growth is an androgen-dependent response, the results of the present study suggest that Lupeol may have a potential to be an effective agent against prostate cancer.