tbuckley/cabot-search huggingface dataset:
T helper cells recognize an idiotope located on peptide 88-114/117 of the light chain variable domain of an isologous myeloma protein (315).
Authors: T Jørgensen, B Bogen, K Hannestad
Journal: The Journal of Experimental Medicine (1983)

Isolated variable region light chain 315 (VL-315), the VL domain of a myeloma protein of BALB/c origin, induces T cells of BALB/c (H-2d) mice that help the adoptive secondary anti-4-hydroxy-3-iodo-5-nitrophenylacetyl (NIP) antibody response to NIP-Fab315. The location of the epitope recognized by helper cells was examined with two fragments of VL-315, obtained by cleavage with cyanogen bromide at Met 87. Both N-terminal fragment 1-86 and C-terminal fragment 88-114/117 elicited BALB/c antibodies that bound to the respective fragments and to VL-315. By contrast, only fragment 88-114/117, which consists of the third hypervariable region, J region, and 5-7 amino acids of the C region, induced helper cells that augmented the anti-NIP response to NIP-Fab 315.
Successful treatment of Bacillus cereus infection with ciprofloxacin.
Authors: A D Gascoigne, J Richards, K Gould, G J Gibson
Journal: Thorax (1991)

Bacillus cereus is rarely a pulmonary pathogen but may cause pneumonia in immunocompromised patients. A patient with bronchiectasis and no recognisable immunodeficiency had this organism isolated during two infective exacerbations, once from respiratory secretions and once by blood culture. Ciprofloxacin treatment was effective on both occasions.
Mcl-1 expression predicts progression-free survival in chronic lymphocytic leukemia patients treated with pentostatin, cyclophosphamide, and rituximab
Authors: Farrukh T. Awan, Neil E. Kay, Melanie E. Davis, Wenting Wu, Susan M. Geyer, Nelson Leung, Diane F. Jelinek, Renee C. Tschumper, Charla R. Secreto, Thomas S. Lin, Michael R. Grever, Tait D. Shanafelt, Clive S. Zent, Timothy G. Call, Nyla A. Heerema, Gerard Lozanski, John C. Byrd, David M. Lucas
Journal: Blood (2008)
Multidisciplinary Management of Patients With Cirrhosis: A Need for Care Coordination
Authors: Jessica L. Mellinger, Michael L. Volk
Journal: Clinical Gastroenterology and Hepatology (2012)

Cirrhosis is a common chronic condition with high rates of morbidity and mortality. Optimal medical management involves a multidisciplinary approach, but coordination between medical specialties needs to be improved. This clinical perspective discusses care coordination interventions that have been successful in other disease states and how they could be applied to the management of cirrhosis.
Mammographic Parenchymal Features and Breast Cancer in the Breast Cancer Detection Demonstration Project
Authors: J. Brisson, A. S. Morrison, N. Khalid
Journal: JNCI Journal of the National Cancer Institute (1988)

The Breast Cancer Detection Demonstration Project (BCDDP) screened 283,222 U.S. women for breast cancer by use of mammography and breast palpation. A sample participants was followed up to determine the subsequent occurrence of breast cancer cases and deaths. We have used information from the BCDDP to evaluate the relation mammographic parenchymal features to the incidence and mortality from breast cancer, and to examine changes in this relation with duration of follow-up. We also reevaluated the relations of age, body weight, height, menopause, parity, and age at birth of first child to mammographic features of breast tissue. Among women 35–49 years of age at entry, those whose mammographic features were “glandular” or “homogeneously dense” had a 2.8-fold increase in risk of breast cancer compared to women whose mammographic features were “atrophic or fatty”. The increased risk was observed up to 9 years after entry. Among women 50–74 years of age at entry, the risk of breast cancer was elevated by a factor of 1.7 for women with glandular or dense breast parenchyma compared to those with atrophic or fatty breasts. The increase in risk, however, diminished with increasing follow-up. The percentage of women with glandular or dense parenchymal features decreased as age, body weight, and parity increased. The percentage with glandular or dense features increased as height increased, and the percentage decreased with menopause. Mammographic parenchymal features were not associated with age at birth of first child. [J Natl Cancer Inst 1988;80:1534–1540]
Miryachit: A Newly Described Disease of the Nervous System and its Analogues
Authors: W. A. Hammond
Journal: BMJ (1884)

enforced about three months; the maximum of daily temperature having been noted, 93.5°on August 9th, when yellow fever had begun in Brownsville ; and it had fallen to 65.50 on November 14th, when it had altogether ceased at Brownsville.-At Pensacola the disease raged between September 8th.and October 26th; the greatest number of attacks in any one day having been 77, and of deaths 11.The last attack occurred on November 26th, and the last death on the 29th.Tlle general opinion held in the United States is, that no infected place can be considered safe until a frost has set in, which was not seen in those instances.It is important to know that at Brownsville the majority of inhabi- tants were of Mexican, and at Pensacola, of Negro race; which accounts in a degree for the mildness of the disease.This concludes the general information combined in the report of the supervising surgeon-general.The history of the epidemics is very instructive in a pathologcal sense, but that may lie beyond the im- mediate scope of this notice; which has been merely to show, at this moment, when a Bill is before Parliament to devise means to diminish sacrifice of life amongst our merchant-seamen, how much it is possible to effect in the direction of curing their diseases.
Cause-specific mortality in type 2 diabetes. The Verona Diabetes Study.
Authors: R de Marco, F Locatelli, G Zoppini, G Verlato, E Bonora, M Muggeo
Journal: Diabetes Care (1999)

OBJECTIVE: This population-based study, carried out in the framework of the Verona Diabetes Study, investigated mortality from specific causes in known type 2 diabetic patients. RESEARCH DESIGN AND METHODS: A cohort of 7,148 known type 2 diabetic patients (3,366 men and 3,782 women) was identified on 31 December 1986 and followed up for 5 years (1987-1991). Underlying causes of death were obtained from death certificates and were coded according to the International Classification of Diseases, Ninth Revision. Cause-specific death rates of diabetic subjects were compared with those of the inhabitants of Verona. By 31 December 1991, 1,550 diabetic subjects (744 men and 806 women) had died. RESULTS: The standardized mortality ratio (SMR) for all causes of death was 1.42 (95% CI 1.35-1.50). The highest SMRs were for the following specific causes: diabetes (SMR 4.47 [3.91-5.10]), gastrointestinal diseases (1.83 [1.50-2.21])--particularly liver cirrhosis (2.52 [1.96-3.20])--and cardiovascular diseases (1.34 [1.23-1.44]), particularly cerebrovascular (1.48 [1.25-1.73]) and ischemic heart diseases (1.41 [1.24-1.62]). A significantly higher than expected risk of mortality for cardiovascular causes was already present in the first 5 years after diagnosis and decreased with age. Type 2 diabetic patients treated with insulin had a higher risk of dying than those treated orally or by diet. CONCLUSIONS: The highest SMRs in the diabetic cohort were for diabetes and liver cirrhosis. The mortality risk for cardiovascular diseases, although significantly higher than expected, was much lower in Italian type 2 diabetic patients than that reported for American patients. The evidence of an early effect on mortality suggests that prevention, early diagnosis, and treatment should be improved.
Undrained Brains
Authors: Ralph Crawshaw
Journal: New England Journal of Medicine (1982)

Most physicians are aware of the "brain drain," which siphons off trained physicians from developing countries into the manpower pool of developed countries, but unfortunately, few physicians appreciate the role of undrained brains — the bright, dedicated, highly trained physicians of the Third World who have chosen to remain and practice scientific medicine under the often daunting conditions of their native land. Unwittingly, physicians of the prosperous countries may even mistake undrained brains for fools or failures, confusing their high professional dedication with parochial ignorance. In any case, physicians in developed countries can properly recognize the contributions of their undrained . . .
Novel etodolac analog SDX-308 (CEP-18082) induces cytotoxicity in multiple myeloma cells associated with inhibition of β-catenin/TCF pathway
Authors: H Yasui, T Hideshima, H Ikeda, E M Ocio, T Kiziltepe, S Vallet, Y Okawa, P Neri, K Sukhdeo, K Podar, D Chauhan, P G Richardson, N Raje, D R Carrasco, K C Anderson
Journal: Leukemia (2007)
Dormia Baskets Impacted in the Bile Duct: Release by Extracorporeal Shock-Wave Lithotripsy
Authors: G. Sauter, M. Sackmann, J. Holl, J. Pauletzki, T. Sauerbruch, G. Paumgartner
Journal: Endoscopy (1995)

See also: Retrieval of an Impacted Mechanical Lithotripsy BasketEndoscopy 1997; 29(02): 128-128DOI: 10.1055/s-2007-1004088 See also: Novel Methods of Management of Trapped Dormia Baskets in the Pancreatic and Biliary DuctsEndoscopy 1997; 29(02): 129-130DOI: 10.1055/s-2007-1004089
INTERFERENCE BETWEEN VIRUSES IN TISSUE CULTURE
Authors: Edwin H. Lennette, Hilary Koprowski
Journal: The Journal of Experimental Medicine (1946)

The influence of one virus on the growth of another in tissue culture was investigated. The 17DD High strain of yellow fever virus was found capable of completely suppressing the growth of both the Asibi strain of the same virus and of the heterologous West Nile virus, even when these were added to the cultures in large amounts. The 17DD High strain of yellow fever virus and the West Nile virus produced either partial or complete suppression of growth of the Venezuelan equine encephalomyelitis virus, depending upon the quantity of the latter inoculated into the cultures. Owing to lack of methods for the detection of interference except in a single direction, reciprocal interference with these viruses could not be investigated. The 17DD High strain of yellow fever virus and the West Nile virus were able to suppress completely, or almost completely, the growth of influenza A virus added to the infected cultures in maximal amounts. Interference in the reverse direction, even with the use of small amounts of the neurotropic viruses, was not demonstrable. Cultures infected with the 17DD High strain of yellow fever virus were examined for the presence of neutralizing antibodies and non-specific antiviral substances; neither was found present.
Hepatitis in Selective IgA Deficiency
Authors: J. Benbassat, L. Keren, A. Zlotnic
Journal: BMJ (1973)

Hepatitis occurred in five out of 12 patients with selective IgA deficiency who had been detected by immunelectrophoretic screening of 2,600 individuals. This apparent increased susceptibility to hepatitis has not been reported before, and it may be due to the defect in their local and humoral immune mechanisms.
The Early Diagnosis of Diseases of the Chest
Authors: Norman J. Wilson
Journal: New England Journal of Medicine (1945)

THE early diagnosis of diseases of the chest is a matter of more importance to the physician today than at any time in the history of medicine. This is true for the following reasons. Intrathoracic abnormalities and diseases are more frequent than has ever been suspected before, as has been revealed by mass x-ray surveys in recent years. Modern diagnostic procedures make early diagnosis more easily attainable than ever before. Modern medical and surgical procedures offer a better chance of control or cure in most diseases of the chest than ever before. Early diagnosis, which is essential to successful therapy, . . .
The impact of organ dysfunction in cirrhosis: Survival at a cost?
Authors: Debbie L. Shawcross, Mark J. Austin, Robin Daniel Abeles, Mark J.W. McPhail, Andrew D. Yeoman, Nicholas J. Taylor, Andrew J. Portal, Khaleel Jamil, Georg Auzinger, Elizabeth Sizer, William Bernal, Julia A. Wendon
Journal: Journal of Hepatology (2012)
Laceration of the Vagina and Uterus
Authors: J. C. W. Lever
Journal: BMJ (1850)

is a married woman, and has been so for six years.She has had three children; she was confined of the first, ten months after marriage; it was still born; the labour was lingering, but she recovered well.The second child was born at the end of about another year, and lived fourteen months; and the third, a boy, after about the same period.
A potent erythropoietin-mimicking human antibody interacts through a novel binding site
Authors: Zhihong Liu, Vincent S. Stoll, Peter J. DeVries, Clarissa G. Jakob, Nancy Xie, Robert L. Simmer, Susan E. Lacy, David A. Egan, John E. Harlan, Richard R. Lesniewski, Edward B. Reilly
Journal: Blood (2007)
US clinics fear violence after execution of antiabortion murderer
Authors: J. H. Tanne
Journal: BMJ (2003)

US family planning clinics, women's health centres, and abortion providers fear new attacks after Paul Hill was executed in Florida for murdering a doctor who provided abortions, and his volunteer bodyguard.

   ![][1] 

Paul Hill was executed last week

Credit:PETER COSGROVE/AP

Hill, a former Protestant preacher, killed Dr John Bayard Britton, aged 69, and his guard, James Barrett, 74, a retired lieutenant colonel in the air force, …

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Increasing the Global Health Workforce—Reply
Authors: Ryan J. Jense, Aruna Kamath
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
1021-57 Cardiac Involvement and Anticardiolipin Antibodies Levels in Primary Antiphospholipid Syndrome: A Transesophageal Study
Authors: Maurizio Turiel, Edoardo Rossi, Cristina Crema, Anna Frisinghelli, Sabrina Muzzupappa, Mariapia Serrago
Journal: Journal of the American College of Cardiology (1995)
The Use of Animal AHG-Concentrates in Patients with Circulating Anticoagulants.
Authors: Robert E. Rubin
Journal: Annals of Internal Medicine (1966)

s1 May 1966The Use of Animal AHG-Concentrates in Patients with Circulating Anticoagulants.Robert E. Rubin, M.D., Harvey Gralnick, M.D., Julian Niemetz, M.D., Solomon Estren, M.D., F.A.C.P., Louis E. Wasserman, M.D., F.A.C.P.Robert E. Rubin, M.D.Search for more papers by this author, Harvey Gralnick, M.D.Search for more papers by this author, Julian Niemetz, M.D.Search for more papers by this author, Solomon Estren, M.D., F.A.C.P.Search for more papers by this author, Louis E. Wasserman, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1165_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe patient with hemophilia and a circulating anticoagulant often represents a grave medical emergency not responsive to therapy with fresh frozen plasma, since the anticoagulant blocks the action of antihemophiliac globulin (AHG). Concentrates of AHG of animal origin afford a therapeutic approach which has not been previously reported in this country.We have studied four patients with circulating anticoagulants directed against AHG, three of whom were known hemophiliacs. The fourth did not have hemophilia, but, at age 62, was found to have a circulating anticoagulant directed against AHG. Three of these patients developed, at various times, severe life-threatening pharyngeal hemorrhages,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Robert E. Rubin, M.D.; Harvey Gralnick, M.D.; Julian Niemetz, M.D.; Solomon Estren, M.D., F.A.C.P.; Louis E. Wasserman, M.D., F.A.C.P.Affiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1165-1165KeywordsAnticoagulant therapyAnticoagulantsBlood plasmaGlobulinsHemophiliaHemorrhage ePublished: 1 December 2008 Issue Published: 1 May 1966 PDF downloadLoading ...
Conservative Management of Breast Cancer: New Surgical and Radiotherapeutic Techniques
Authors: Donald J. Ferguson
Journal: JAMA (1984)

The policy of treating breast cancer primarily by radiotherapy raises two questions: (1) Is this method an improvement on radical surgery? (2) How does one deal with the uncertainty as to the extent of local and regional disease? These questions are addressed in 30 papers, mostly by radiotherapists from leading centers in the world, originally presented at a symposium held in May 1982. The presentations are grouped under the following topics: retrospective studies, prospective studies, pathology, surgery, internal mammary nodes, irradiation, sequelae, and adjuvant chemotherapy with primary irradiation. A critical consensus is presented after each group and at the end. The first question is answered affirmatively, on the basis of apparently equal survival, with improved cosmesis, in all but one of the 11 papers in the first two groups. The first eight papers, however, lack randomized controls; other statistical defects include variations within treatment protocols, exclusion of cases deemed unsuitable,
Erythrocyte Sodium-Lithium Countertransport Activity in Non-Nephropathic Diabetic Twins
Authors: Timothy C Hardman, Simon W Dubrey, R David G Leslie, Ariel F Lant
Journal: Diabetes Care (1996)

OBJECTIVE It has proved difficult to separate the role of the diabetic state as distinct from its complications in causing the elevation in erythrocyte sodium-lithium (Na-Li) countertransport activity that has been observed in diabetes. The present study sought to isolate the impact of diabetes on the countertransporter by studying groups of non-nephropathic identical-twin pairs both discordant and concordant for diabetes. RESEARCH DESIGN AND METHODS We studied erythrocyte Na-Li countertransport activity in 49 identical-twin pairs who were discordant for IDDM and 26 identical twin pairs who were concordant for IDDM. Similar numbers of healthy control subjects, matched with the nondiabetic twins from the discordant pairs in respect to sex, BMI, and age were also studied. RESULTS The clinical and laboratory characteristics of both sets of twins were very similar to those of the control subjects with the exception that whole-blood glucose and glycated hemoglobin concentrations were higher in diabetic twins, whether from discordant or concordant pairs (P &amp;lt; 0.001), and that systolic blood pressure (P &amp;lt; 0.05) and serum HDL cholesterol (P &amp;lt; 0.05) were higher in the discordant diabetic twins than in their nondiabetic co-twins. Median (95% CI) Na-Li countertransport activities (in millimoles of lithium released from 1 liter of erythrocytes per hour) in the nondiabetic discordant twin [0.237 (0.192–0.284)], the diabetic discordant twin [0.284 (0.254–0.326)], and the concordant twin [0.262 (0.207–0.358)] groups were similar to each other and higher than in the control subjects [0.172 (0.138–0.203)]. Countertransport activities in the discordant diabetic twins correlated significantly with their nondiabetic co-twins (r = 0.34; P = 0.015; n = 49), as did those between the concordant diabetic twin pairs (r = 0.68; P &amp;lt; 0.005; n = 26); activity levels were not related to either disease duration or blood glucose control. CONCLUSIONS An elevation in Na-Li countertransport activity has been noted in non-nephropathic normotensive twin pairs both discordant and concordant for IDDM. The potential genetic contribution to the altered behavior of the countertransporter was similar in both types of twins studied, and individual Na-Li countertransport activities were not significantly related to either duration of diabetes or metabolic control.
Detection and quantitation of C16 and C18 fatty acid acyl conjugates of triamcinolone acetonide (TAA) in airway epithelial cells using gas chromatography-mass spectrometry
Authors: R.P. Schleimer, A.E. Blum, C.A. Bickel, N.M. Heller, W.C. Hubbard
Journal: Journal of Allergy and Clinical Immunology (2003)
AIDS and the lung. 8. AIDS, ethics, and the respiratory physician.
Authors: M Brazier, M Lobjoit
Journal: Thorax (1990)

Acquiring HIV infection and the subsequent development of AIDS is currently seen by many as equivalent to receiving the death sentence.The long latency and uncertain delay before death occurs makes HIV infection and AIDS a uniquely horrifying disease.As if this were not enough, association with homosexual practice and drug abuse has created prejudice among both the medical profession and the general public.These unique problems with HIV infection have made us re-examine and redefine our general ethical approach to all patients, especially with regard to consent and confiden- tiality.In the United Kingdom the General Medical Council has produced a general framework for the management of HIV positive patients.'Ifa cure or vaccine for AIDS were discovered then many of these ethical problems would disappear.Until that time ignorance and fear of AIDS will continue to contribute to a mistrust of the medical profession by some patients and in some cases a mistrust of the patients on the part of the physicians.This article looks at how basic medical ethical principles can be applied to the special problems arising in the management ofpatients with AIDS, with specific reference to res- piratory medicine.
IMPACT OF GENDER ON MORTALITY AT LONG–TERM FU IN STEMI WITH MULTIVESSEL DISEASE AFTER PRIMARY PCI
Authors: Shirda Imami, Matthijs Bax, Arnout Haasdijk, Carl Schotborgh, Jan Willem Bech, Lucas Savalle, Pranobe Oemrawsingh
Journal: Journal of the American College of Cardiology (2013)
Mandated Choice for Organ Donation
Authors: John Glasson
Journal: JAMA (1995)

<h3>To the Editor.</h3> —In their Editorial<sup>1</sup>about two reports<sup>2,3</sup>on organ procurement by the Council on Ethical and Judicial Affairs, Drs Murray and Youngner misjudge the reports on several counts. One report endorses mandated choice,<sup>2</sup>the other endorses limited financial incentives for procurement after death.<sup>3</sup> Murray and Youngner<sup>1</sup>seem troubled by what they perceive as an undue emphasis on individual autonomy and an insufficient recognition of family interests. The Council takes the prevailing view that individuals have the right to decide what happens to their organs after they die. Society shows its respect for the essential worth of each person by permitting individuals to control their bodies even after death. Whatever the family's interests, it is clear that people have strong feelings about what happens to them after they die. It would be ironic if individuals had less control over the disposition of their bodies