tbuckley/cabot-search huggingface dataset:
Future directions for the ERS: Presidential plans
Authors: Francesco Blasi, Peter J. Barnes, Mina Gaga, Giovanni Battista Migliori
Journal: European Respiratory Journal (2013)

The mission of the European Respiratory Society (ERS) is to promote respiratory health and alleviate suffering from respiratory disease and it fulfils this goal by promoting science/research, education and advocacy. Among the Society's activities are a successful annual Congress (attended by approximately 20,000 delegates), research fellowships, grants and seminars and a comprehensive educational programme through the ERS School [1–5]. The educational programme encompasses postgraduate courses during the Congress, courses and seminars on various topics throughout the year across Europe, a website with a wealth of educational modules and interactive materials. Importantly, the ERS School has initiated a training programme called Harmonisation in Education in Respiratory Medicine for European Specialists (HERMES), which sets training standards across Europe, runs examination and certification processes for the European Diplomas in Respiratory Medicine and Paediatric Respiratory Medicine, and allows mobility of European specialists. Furthermore, the ERS has a strong advocacy role through its Advocacy Committee and Brussels office, and through the European Lung Foundation (ELF) – the public voice of the ERS, which links with patients and patient organisations, provides information and listens to and empowers the patients' voices.

In a dynamic European and global setting, where health priorities in general (and respiratory medicine in particular) are changing rapidly, the ERS is planning to do even more in order to attract the attention of the media and policymakers and to bring more research funding into respiratory medicine. The ERS is proud to be the first major respiratory medicine society to have agreed and launched a public health Presidential plan, which is now being implemented.

A series of ERS Summits has been organised since 2011, when the European Respiratory Roadmap , which set out directions for respiratory medicine and research over the next decade, was approved in Leuven (Belgium) and was then …
Subcorneal pustular dermatosis and IgA paraproteinaemia: response to both etretinate and PUVA
Authors: D. J. TODD, E. A. BINGHAM, M. WALSH, D. BURROWS
Journal: British Journal of Dermatology (1991)

A non‐insulin dependent male diabetic is reported with subcorneal pustular dermatosis associated with intraepidermal IgA deposits and a benign IgA paraproteinaemia. Treatment with dapsone and etretinate was reasonably effective, but etretinate had to be discontinued due to the development of diffuse idiopathic skeletal hyperostosis. His subcorneal pustular dermatosis subsequently flared and was troublesome for 2 years until he was commenced on PUVA, with excellent response.
Pica, Pagophagia, And Anemia
Authors: Louis G. Keith
Journal: JAMA (1969)

<h3>To the Editor:—</h3> The recent article on pagophagia and the accompanying editorial comment (<b>207</b>:513, 1969;<b>207</b>:552, 1969) point out one of the most preplexing aspects in the study of the many forms of pica. This problem is to determine whether the associated anemia is the cause of perversion of the appetite or whether perversion of the appetite indeed causes anemia. While it is tempting to look for a direct cause and effect relationship, critical examination of the many available reports does not settle the question. We agree wholeheartedly that it would appear prudent to keep an open mind to the possibility that many factors may be operational at the same time. We have begun to reexamine our own material and premises in this area. Our original article noted an absolute incidence of 34.6% of 1,000 obstetric patients admitting to amylophagia during pregnancy (<i>Obstet Gynec</i><b>32</b>:415, 1968). An
John Edward Lawson Price
Authors: D. Price
Journal: BMJ (2002)

Former general surgeon and general practitioner Churchill Falls, Labrador, Canada (b London 1920; q London 1943; FRCS), died after a short illness in Prince Edward Island, Canada, on 21 April 2002.

After house jobs, John worked as a surgeon in India, Iran, and Nigeria before coming to Canada. He spent 20 years in Labrador and after retirement did locums in places such as Pitcairn Island. He split his last 10 years between Prince Edward Island and South Africa. He leaves a wife Kate; four children; and 10 grandchildren.
Multimodality Noninvasive Imaging Demonstrates In Vivo Cardiac Regeneration After Mesenchymal Stem Cell Therapy
Authors: Luciano C. Amado, Karl H. Schuleri, Anastasios P. Saliaris, Andrew J. Boyle, Robert Helm, Behzad Oskouei, Marco Centola, Virginia Eneboe, Randell Young, Joao A.C. Lima, Albert C. Lardo, Alan W. Heldman, Joshua M. Hare
Journal: Journal of the American College of Cardiology (2006)
The Millennium Development Goals Fail Poor Children: The Case for Equity-Adjusted Measures
Authors: Daniel D. Reidpath, Chantal M. Morel, Jeffrey W. Mecaskey, Pascale Allotey
Journal: PLoS Medicine (2009)

© 2009 Reidpath et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Molecular Basis of the Specificity of Binding of Glycoprotein Hormones to Their Receptors
Authors: YVES COMBARNOUS
Journal: Endocrine Reviews (1992)

THREE glycoprotein hormones are synthesized and secreted by the pituitary under hypothalamic control. Two of them are the gonadotropins, LH and FSH, and the third one is TSH. During gestation in primates and equidaes an additional gonadotropin, CG, is secreted by the placenta. Pituitary gonadotropins play pivotal roles in the control of reproductive function in both the female (1, 2) and the male (3) while the main role of TSH is in the control of thyroid gland activity (4). Although the human (h) and equine (e) CGs (the latter previously named PMSG) have been studied extensively, the full extent of their roles remains equivocal (5, 6). Glycoprotein hormones form a family of structurally related molecules that are among the most complex molecules possessing hormonal activities. Despite their extensive homologies, these hormones exhibit high specificities, indispensable for their respective and often coordinated physiological roles. The present review is an attempt to summarize and interpret the available data concerning the molecular basis for their highly specific interaction with their receptors.
Canadian court decision challenges new rules on medical marijuana
Authors: O. Dyer
Journal: BMJ (2014)

Canada’s rules on producing and prescribing medical marijuana are set to change radically on 1 April as the federal government seeks to eliminate home growers’ permits that it says have led to “unintended consequences” and “exponential growth” in the industry. But a last minute injunction from a federal court means that the law will go into effect with its key provision—that home growers destroy their plants—suspended.

The Marihuana for Medical Purposes Regulations removed the right of medical marijuana permit holders to grow their own plants or buy marijuana from other permit holders. Instead, the regulations aimed to limit production to about 20 licensed commercial producers …
Menopausal Flushing: Double-blind Trial of a Non-hormonal Medication
Authors: J. R. Clayden, J. W. Bell, P. Pollard
Journal: BMJ (1974)

A multicentre, placebo-controlled, double-blind, cross-over study conducted in general practice on 100 patients has shown clonidine to have a statistically highly significant effect in controlling the number and the severity and duration of menopausal flushes. The relatively mild side effects and the absence of potentially harmful oestrogenic effects suggest that clonidine in the dose range 25 to 75 μg twice daily is a useful addition or alternative to the existing therapy for this common symptom of the menopause.
Marny Ann Mitchell (née Lloyd-Jacob)
Authors: Oscar Mitchell, Desmond Sharland
Journal: BMJ (2004)

​TeacherTeacher of anatomy Royal Free Hospital Medical School and University College London (b Surrey 1931; q Royal Free Hospital, London, 1957; MSc, PhD), died from uterine cancer on 19 February 2004.




Figure 1




After having gained her PhD and a spell as associate professor of anatomy at the Rockefeller Institute in New York, Marny returned to the anatomy department at the Royal Free Hospital Medical School. Her teaching inspired many generations of students. With a close friend she set up and ran a small trust to alleviate mental illness and she supported the relatives of people with mental illness. Marny leaves a husband, two children, and four grandchildren.
Left Ventricular, Peripheral Vascular, and Neurohumoral Responses to Mental Stress in Normal Middle-Aged Men and Women
Authors: Lewis C. Becker, Carl J. Pepine, Robert Bonsall, Jerome D. Cohen, A. David Goldberg, Cecil Coghlan, Peter H. Stone, Sandra Forman, Genell Knatterud, David S. Sheps, Peter G. Kaufmann
Journal: Circulation (1996)

Background The normal cardiovascular response to mental stress in middle-aged and older people has not been well characterized. Methods and Results We studied 29 individuals 45 to 73 years old (15 women, 14 men) who had no coronary risk factors, no history of coronary artery disease, and a negative exercise test. Left ventricular (LV) volumes and global and regional function were assessed by radionuclide ventriculography at rest and during two 5-minute standardized mental stress tasks (simulated public speaking and the Stroop Color-Word Test), administered in random order. A substantial sympathetic response occurred with both mental stress tests, characterized by increases in blood pressure, heart rate, rate-pressure product, cardiac index, and stroke work index and rises in plasma levels of epinephrine and norepinephrine but not β-endorphin or cortisol. Despite this sympathetic response, LV volume increased and ejection fraction (EF) decreased secondary to an increase in afterload. The change in EF during mental stress varied among individuals but was associated positively with changes in LV contractility and negatively with baseline EF and changes in afterload. EF decreased &gt;5% during mental stress in 12 individuals and &gt;8% in 5; 3 developed regional wall motion abnormalities. Conclusions Mental stress in the laboratory results in a substantial sympathetic response in normal middle-aged and older men and women, but EF commonly falls because of a concomitant rise in afterload. These results provide essential age- and sex-matched reference data for studies of mental stress–induced ischemia in patients with coronary artery disease.
Clinical Trial of Hyposensitisation in Hay Fever: Two Methods of Relating Symptom Scores to Daily Pollen Counts
Authors: P. Wilkinson, E. Taudorf
Journal: Allergy (1984)

Two methods of relating daily pollen counts to patients' symptom scores in clinical trials of hyposensitisation in hay fever are described. The problems involved in comparing results from different centres and years of a trial are discussed with particular reference to symptoms which are not pollen related. The Normalised Regression method is a powerful technique, but often the Pollen Interval method is preferable on the grounds of simplicity of communication and calculation.
Efficacy and safety of itolizumab, a novel anti-CD6 monoclonal antibody, in patients with moderate to severe chronic plaque psoriasis: Results of a double-blind, randomized, placebo-controlled, phase-III study
Authors: D.S. Krupashankar, Sunil Dogra, Mahendra Kura, Abir Saraswat, Leelavathy Budamakuntla, T.K. Sumathy, Radha Shah, M.G. Gopal, T. Narayana Rao, C.R. Srinivas, Ramesh Bhat, Narendra Shetty, G. Manmohan, Kotla Sai Krishna, Dalavoi Padmaja, Dasiga Venkata Subrahmanya Pratap, Vijay Garg, Sandesh Gupta, Neeraj Pandey, Uday Khopkar, Enrique Montero, M.S. Ramakrishnan, Pradip Nair, Prasanna C. Ganapathi
Journal: Journal of the American Academy of Dermatology (2014)
Pulmonary hypertension after splenectomy: a consequence of loss of the splenic filter or is there something more?
Authors: A J Peacock
Journal: Thorax (2005)

The exact mechanism by which pulmonary hypertension develops after splenectomy remains unclear

Pulmonary arterial hypertension is a syndrome—not a disease—and has a number of causes.1 Included in these causes are a wide range of pathoaetiologies such as HIV infection, portopulmonary hypertension, intracardiac shunt, chronic thromboembolic disease, hypoxic lung disease, connective tissue disease, idiopathic pulmonary hypertension, and familial pulmonary hypertension associated with mutation of the BMPR2 gene.

In this issue of Thorax Jais et al 2 have examined the clinical background of 257 patients referred to their centre for treatment of chronic thromboembolic pulmonary hypertension (CTEPH). They found that 8.6% of the patients had a history of splenectomy compared with 2.5% of patients with idiopathic pulmonary hypertension (IPH) and 0.4% in the general population. They concluded that splenectomy alone had caused thromboembolism and hence the pulmonary hypertension in these patients. But is this true?

Chronic thromboembolic disease has been defined as “pulmonary hypertension caused by the absence of thrombus resolution after acute pulmonary embolism which has resulted in sustained obstruction of the pulmonary circulation”. This view is probably outdated because in 50% of cases there is no definite history of venous thrombosis and it is likely that many cases are a consequence of in situ thrombosis.3 Bonderman et al 4 have recently looked at the medical conditions that increased the risk of CTEPH in 109 consecutive patients and found that splenectomy increased the relative risk of this condition by a factor of 13.

The findings of Jais et al 2 and Bonderman et al 4 are not new—for example, …
Cutaneous sarcoidosis in a patient with philadelphia-positive chronic myelogenous leukemia treated with interferon-α
Authors: Leonid L. Yavorkovsky, George Carrum, Suzanne Bruce, Philip L. McCarthy
Journal: American Journal of Hematology (1998)

A patient with Philadelphia-positive (Ph+) chronic myelogenous leukemia (CML) was diagnosed with cutaneous sarcoidosis after treatment with interferon-alpha (IFN-α). Following IFN-α dose reduction, the skin lesions disappeared. Few cases of sarcoidosis associated with IFN treatment have been reported, and only in one patient with pre-existing CML. Our patient was unique in that (1) the sarcoidosis was induced by the IFN-α treatment alone, (2) it developed de novo, and (3) it was confined to the skin. Am. J. Hematol. 58:80–81, 1998. © 1998 Wiley-Liss, Inc.
Parental History of Diabetes in a Population-Based Study
Authors: Barbara E K Klein, Ronald Klein, Scot E Moss, Karen J Cruickshanks
Journal: Diabetes Care (1996)

OBJECTIVE To evaluate the relative frequency of parental history of diabetes in a population-based study of younger- and older-onset groups of individuals with diabetes and a comparison group of individuals without diabetes. RESEARCH DESIGN AND METHODS Study participants were queried about a family history of diabetes. The frequencies of positive responses for parents and siblings were compared between younger- and older-onset groups. RESULTS At least one parent had diabetes in 18.6% of the families of younger-onset individuals and in 38.6% of the families of older-onset individuals. For those of younger-onset diabetes, 9.1% of fathers, 8.3% of mothers, and 1.3% of both parents had diabetes; the corresponding percentage for those of older-onset diabetes were 11.5, 23.5, and 3.6%, respectively. The difference between frequencies in mothers and fathers was significant (P &amp;lt; 0.0001) in the older-onset group. In the nondiabetic comparison group, for those of similar ages to the younger- and older-onset groups, the corresponding frequencies were 6.2 and 9.0% and 7.7 and 9.8% for fathers and mothers, respectively. The greater frequencies of diabetes in mothers of older-onset diabetic individuals were not accounted for by maternal age. In younger-onset individuals, the relative risk (RR) of diabetes in a sibling if the father had diabetes was 1.22 (95% CI, 0.72–2.05); if the mother had diabetes, the RR was 2.39 (95% CI, 1.64–3.48); and, if both parents had diabetes, the RR was 5.61 (95% CI, 3.37–9.34). In the older-onset individuals, the corresponding RR values were 1.69 (95% CI, 1.35–2.13) for fathers, 1.72 (95% CI, 1.44–2.06) for mothers, and 2.42 (95% CI, 1.81–3.25) for both parents. CONCLUSIONS These data confirm a familial influence on the frequency of diabetes. The excess of cases in mothers of older-onset diabetic individuals is compatible with both environmental and genetic influences.
Non-Hodgkin's Lymphoma of Supraclavicular Lymph Nodes Can Mimic Metastasis of Breast Cancer During Chemotherapy on FDG PET/CT
Authors: Fengchun Hua, Xiaoyuan Feng, Yihui Guan, Jun Zhao, Zhemin Huang
Journal: Clinical Nuclear Medicine (2009)

A 43-year-old woman who had a history of right mastectomy for breast cancer presented with fever and swelling in the right supraclavicular region during her second course of chemotherapy. An FDG PET/CT was performed to evaluate this patient, which revealed mildly increased FDG activity in the lymph node in the supraclavicular region. A metastatic lesion from the known breast cancer was considered. However, biopsy results demonstrated that the abnormal activity in the right supraclavicular region is due to T-cell lymphoma.
Inter-method variability in PTH measurement: Implication for the care of CKD patients
Authors: J.-C. Souberbielle, A. Boutten, M.-C. Carlier, D. Chevenne, G. Coumaros, E. Lawson-Body, C. Massart, M. Monge, J. Myara, X. Parent, E. Plouvier, P. Houillier
Journal: Kidney International (2006)
Abstract 2680: Characterization of tumor associated antigens using a recombinant expression of a patient derived breast cancer cDNA library and autologous serum using the SEREX technique
Authors: Leah J. Novinger, Girja Shukla, Stephanie Pero, David N. Krag
Journal: Cancer Research (2011)

Abstract Autoantibodies to tumor proteins in patient serum may serve as biomarkers in breast cancer diagnosis or as a potential targeted therapeutic when conjugated to drugs or radiotherapies. The tumor associated antigens (TAAs) to which they bind may be of further diagnostic or prognostic value. In order to identify TAAs, a cDNA library was created from a patient breast tumor, recombinantly expressed with lambda phage in XL1-Blue cells, and tested against autologous patient serum to identify potential TAAs using a modified technique based on serological analysis of recombinant cDNA expression libraries (SEREX) that allows for much smaller quantities of source material and reduces library production time. Identified TAAs and serum autoantibody concentrations against those proteins will be presented in the context of developing a new customized therapy for patients with breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2680. doi:10.1158/1538-7445.AM2011-2680
Phase I trial and pharmacokinetic study of high-dose clofarabine and busulfan and allogeneic stem cell transplantation in adults with high-risk and refractory acute leukemia
Authors: S S Farag, L L Wood, J E Schwartz, S Srivastava, R P Nelson, M J Robertson, R Abonour, A Secrest, E Cox, J Baute, C Sullivan, K Kane, D R Jones
Journal: Leukemia (2011)
Abnormally large von Willebrand factor multimers in Henoch-Schönlein purpura
Authors: Alessandra Casonato, Elena Pontara, Antonella Bertomoro, Elena Ossi, Massimo Vincenti, Antonio Girolami, Arturo Borsatti, Giselda Bertaglia
Journal: American Journal of Hematology (1996)

Allergic vasculitis phenomena seem to be involved in Henoch-Schönlein purpura (HSP). Elevated plasma levels of von Willebrand factor (vWf) are a well recognized feature of vasculitis and have been taken as an indication of in vivo endothelial cell damage. Plasma factor VIII:C and vWf levels and vWf multimeric pattern were studied in 8 patients with HSP, during active disease and twice during the remission (3 and 9 months later). Plasma vWf multimeric composition was evaluated using low resolution gels which better resolve large vWf multimers. During active disease plasma factor VIII:C, vWf:Ag, and vWf:RCoF were normal in 5% of patients and increased in three, but in each patient, platelets appeared to aggregate at doses of ristocetin lower than in normals. Furthermore, all patients demonstrated the presence of abnormally large vWf multimers usually found only in platelets and endothelial cells. Three and 9 months later, during remission, in spite of the normalization of factor VIII:C and vWf levels, the abnormal multimers were still detectable, as well as hyper-responsiveness to ristocetin. These findings confirm that damage and/or perturbation of endothelial cells is associated with HSP. Moreover, the persistence of abnormality in the vWf multimeric pattern, when the disease is inactive, suggests that the mechanisms involved operate through the entire clinical course. © 1996 Wiley-Liss, Inc.
Radioactive Isotopes in Clinical Medicine
Authors: Solomon Silver
Journal: New England Journal of Medicine (1965)

ONLY a bold or perhaps naïve person would have dared to accept an invitation to prepare a report on the progress made in the clinical applications of radioactive isotopes during the past ten years. This period covers almost the entire time that these materials have been generally available, and there is hardly an area in clinical or investigative medicine that has not been advanced by their use. It is obvious that in a review of this type much will have to be omitted and some controversial areas will not receive the extensive treatment that others would consider necessary, but an . . .
299 EXPRESSION OF THE 2B4 ADAPTOR MOLECULE SAP AS A DETERMINANT FOR CD8+ T CELL FUNCTION AND DYSFUNCTION IN VIRAL HEPATITIS
Authors: S. Lunemann, P.V. Suneetha, J. Jaroszewicz, J. Grabowski, S. Pischke, F. Helfritz, H. Bektas, M.P. Manns, M. Cornberg, H. Wedemeyer, V. Schlaphoff
Journal: Journal of Hepatology (2011)
Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma.
Authors: T Olsson, W W Zhi, B Höjeberg, V Kostulas, Y P Jiang, G Anderson, H P Ekre, H Link
Journal: Journal of Clinical Investigation (1990)

Multiple sclerosis (MS) is a disease with unknown cause characterized by inflammation and demyelination in the central nervous system. Although an autoimmune pathogenesis has been suggested, there are no conclusive data on the number of T cells autoreactive with myelin antigens in MS compared to controls. We showed that T lymphocytes secreting interferon-gamma in response to possible target autoantigens are severalfold more common among PBL mononuclear cells in patients with MS than in patients with aseptic meningitis and tension headache. On average T cells reactive with myelin basic protein (MBP), two different MBP peptides, or with proteolipid protein amounted to 2.7-5.2/10(5) PBL from MS patients. MBP-reactive T cells were still more frequent among mononuclear cells isolated from the cerebrospinal fluid (CSF; 185/10(5) CSF cells). We concluded that T cells reactive with myelin autoantigens are strongly increased in MS. This approach to detect them could allow definition of immunodominant T cell epitopes in individual MS patients, and thereby enable further development towards specific immunotherapy.