Aerosolized Pentamidine and Pregnancy
Authors: Beth Conover, Jonathan C. Goldsmith, Bruce A. Buehler, Pierre A. Maloley, Mary L. Windle
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 December 1988Aerosolized Pentamidine and PregnancyBeth Conover, RN, MS, Jonathan C. Goldsmith, MD, Bruce A. Buehler, MD, Pierre A. Maloley, PharmD, Mary L. Windle, PharmDBeth Conover, RN, MSSearch for more papers by this author, Jonathan C. Goldsmith, MDSearch for more papers by this author, Bruce A. Buehler, MDSearch for more papers by this author, Pierre A. Maloley, PharmDSearch for more papers by this author, Mary L. Windle, PharmDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-11-927_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPentamidine isethionate is an aromatic diamidine-derivative antiprotazoal agent now being used in treating Pneumocystis carinii pneumonia in patients with immunodeficient disease states (1). The agent is usually administered by the intravenous or intramuscular route. Clinicians, however, have used aerosol preparations in an effort to target the respiratory tract during treatment and to decrease systemic side effects (2, 3). This route of administration presents health care providers with the potential for exposure to pentamidine, and concerns have been expressed that pregnant staff members might have associated adverse reproductive effects.The Nebraska Teratogen Project addressed this concern, and unfortunately, little information is...References1. DrakeLampasonaNicksSchwarzmann SVHS. Pentamidine isethionate in the treatment of Pneumocystis carinii pneumonia. Clin Pharm. 1985;4:507-16. MedlineGoogle Scholar2. ConteHollanderGolden JHJ. Inhaled or reduced-dose intravenous pentamidine for Pneumocystis carinii pneumonia: a pilot study. Ann Intern Med. 1987;107:495-8. LinkGoogle Scholar3. MontgomeryDebsLuce ARJ. Aerosolized pentamidine as sole therapy for Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. Lancet. 1987;2:480-2. CrossrefMedlineGoogle Scholar4. BerkowitzCoustinMochizuki RDT. Handbook for Prescribing Medications During Pregnancy. Boston: Little, Brown & Co. ; 1986:368-9, 379-80. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Beth Conover, RN, MS; Jonathan C. Goldsmith, MD; Bruce A. Buehler, MD; Pierre A. Maloley, PharmD; Mary L. Windle, PharmDAffiliations: University of Nebraska Medical Center Omaha, NE 68105 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEstimation of Fetal Risk From Aerosolized Pentamidine in Pregnant Healthcare WorkersBowenoide Vulvaveränderungen bei HIV-infizierten PatientinnenMedizinische Betreuung HIV-infizierter FrauenEmbryofetal effects of pentamidine isethionate administered to pregnant Sprague-Dawley ratsLes aerosols de pentamidine (AP) en prophylaxie primaire et secondaire de la pneumopathie a Pneumocystis carinii (PPC)Occupational Exposure to Aerosolized PentamidineAerosolized pentamidine in HIV 1 December 1988Volume 109, Issue 11Page: 927-927KeywordsHealth care providersPneumocystis carinii pneumoniaPregnancyRespiratory systemRespiratory system proceduresRoutes of administration ePublished: 1 December 2008 Issue Published: 1 December 1988 PDF downloadLoading ...