Sulindac and Pneumonitis
Authors: Michael Fein
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 August 1981Sulindac and PneumonitisMICHAEL FEIN, M.D.MICHAEL FEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-2-245_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: An increasing number of drugs have been identified as causing hypersensitivity pneumonitis (1, 2). Sulindac is a widely used, nonsteroidal, antiinflammatory agent that is responsible for a growing number of complications, including peptic ulcer, rash, aplastic anemia, hepatitis (3), and pancreatitis (4). Smith and Lindberg (5) have described a patient with rheumatoid arthritis who developed a noninfectious pulmonary infiltrate during treatment with sulindac. Within 4 hours of sulindac rechallenge he developed fever and hypotension without described pulmonary complications. The following case implicates sulindac as causing a severe interstitial pneumonitis.A 76-year-old white woman entered Alta Bates Hospital...References1. ROSENOW E. The spectrum of drug-induced pulmonary disease Ann Intern Med. 1972;77:977-91. LinkGoogle Scholar2. LIPPMANN M. Pulmonary reactions to drugs. Med Clin North Am 1977;61:1353-67. CrossrefMedlineGoogle Scholar3. WOLFE P. Sulindac and jaundice. Ann Intern Med. 1979;91:656. Letter LinkGoogle Scholar4. GOLDSTEINLASKINGINSBERG JDG. Sulindac associated with pancreatitis. Ann Intern Med. 1980;93:151. Letter. LinkGoogle Scholar5. SMITHLINDBERG FP. Life-threatening hypersensitivity to sulindac JAMA. 1980;244:269-70. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MICHAEL FEIN, M.D.Affiliations: University of California San Francisco, CA 94143 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySulindacAdverse immunological effects of drugs other than anticance drugs and drugs used in immunologyNON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs)SulindacDrug-induced eosinophilic lung diseaseEpidemiology of Idiopathic Pulmonary FibrosisRecent advances in the aetiology of cryptogenic fibrosing alveolitisExposure to Commonly Prescribed Drugs and the Etiology of Cryptogenic Fibrosing AlveolitisEosinophilic bronchitis presenting with only severe dry cough due to bucillamineAntirheumatic drug reactions in the lungDrug-Induced Hypersensitivity Reactions in the LungPulmonary complications of antirheumatic drug therapyPulmonary Disease Due to Antirheumatic AgentsPulmonary Infiltrates Associated with Sulindac TherapyGold-Naproxen PneumonitisPulmonary Infiltration and Lymphadenopathy in Association with FenbufenChanges in body temperature after administration of antipyretics, LSD, Δ9-THC and related agents: IIRare adverse reactions to non-steroidal anti-inflammatory drugsAdverse reactions to nonsteroidal anti-inflammatory drugs diclofenac compared with other nonsteroidal anti-inflammatory drugsSulindac Hepatotoxicity: A Case Report and ReviewAnti-inflammatory analgesics and drugs used in rheumatoid arthritis and gout 1 August 1981Volume 95, Issue 2Page: 245-245KeywordsHepatitis AHypersensitivityHypotensionInterstitial lung diseasesNSAIDsPancreatitisPeptic ulcersPneumonitisRashesRheumatoid arthritis ePublished: 1 December 2008 Issue Published: 1 August 1981 PDF downloadLoading ...