tbuckley/cabot-search huggingface dataset:
Temporal patterns of bone marrow cell differentiation following transplantation in doxorubicin-induced cardiomyopathy
Authors: O Agbulut
Journal: Cardiovascular Research (2003)

Objective: Recent studies have suggested benefits of bone marrow cell transplantation for the regeneration of ischemic cardiac tissue. To extend the potential of cell transplantation, we assessed this treatment in a mouse model of acute nonischemic doxorubicin-induced cardiomyopathy. Methods: To allow detection of engrafted cells, we used transgenic mice expressing the nuclear-located LacZ under the control of either desmin or vimentin promoters, which identify muscle lineage and mesenchymal cells, respectively. All transplanted cells were also labeled with the fluorescent dye DIL. One week after the administration of doxorubicin (15 mg/kg), mice were intramyocardially injected with either allogeneic unpurified bone marrow cells (6×106 in 30 μl, n = 59) or purified sca-1pos cells (4×105 in 30 μl, n = 22). In parallel, control normal mice received only unpurified bone marrow cells (n = 28). Hearts were harvested at serial intervals until 2 weeks after transplantation and analyzed by immunohistochemistry to assess the degree of engraftment and transplanted cell differentiation. Results: In control mice, no differentiation of bone marrow cells was detected. In contrast, unpurified bone marrow cells grafted into diseased myocardium featured two successive phases of cell differentiation. The first yielded cells with a mesenchymal phenotype (44.1±10.1 cells/3×10−2 mm3 at 2 days), was transient and lasted 1 week. The second phase was characterized by cells with a muscular phenotype detected in a small number of cells (5.6±2.3 cells/3×10−2 mm3 at 7 days). Two weeks after transplantation, some of these cells appeared phenotypically close to cardiomyocytes, as evidenced by morphology and positive staining for myosin binding protein C, vinculin and myosin heavy chain. In sca-1pos hematopoietic progenitor grafted mice hearts, no transdifferentiation into cardiac cells was detected at any time point. Conclusion: These data support the hypothesis of the potential for a myogenic differentiation of bone marrow cells following engraftment in a nonischemic model of global cardiomyopathy. Bone marrow-derived cells amenable to cardiac differentiation are present in total unpurified bone marrow but not in the sca-1pos hematopoietic progenitor cell population. However, the very small number of transdifferentiated cells raises concerns over their functional efficacy.
REDUCED CARDIOVASCULAR DISEASE RISK FACTORS AND RISK BIOMARKERS FROM A POPULATION-BASED INTERVENTION: THE HEART OF NEW ULM PROJECT, 2-YEAR RESULTS
Authors: Thomas Knickelbine, Jackie Boucher, Abbey Sidebottom, Raquel Pereira, Betsy Pieser, Arthur Sillah, Craig Strauss, Charles Stephens
Journal: Journal of the American College of Cardiology (2012)
Outpatient Anterior Cruciate Ligament Reconstruction and Patient-Controlled Analgesia
Authors: Carl L. Highgenboten
Journal: JAMA (1992)

<h3>To the Editor.</h3> —The rise in medical costs and the need for cost containment are realities. My concern is that those of us who are "proceduralists"—we who look at what we are doing— must try to devise methods that are more efficient and more economical without jeopardizing the patient's safety and without attaining less desirable results just to reduce costs. When I began promoting the idea of 1-day anterior cruciate ligament (ACL) reconstruction surgery for our patients in an outpatient clinic and patient-controlled analgesia (PCA), I confronted all sorts of objections from my colleagues, nursing staff, and patients. After approximately 160 consecutive cases under the outpatient ACL-PCA protocol at our clinic, I can document and demonstrate excellent results with a net savings of approximately $5000 per patient or $800 000 to whomever pays the bill. The net savings takes into account the cost of PCA and home health care. These
The Importance of Self-Assessed Health in Patients with Diabetes
Authors: Margaret W Linn, Bernard S Linn, Jay S Skyler, Rachel Harris
Journal: Diabetes Care (1980)

The role of self-assessment of health was compared in 150 diabetic and nondiabetic male outpatients matched for age and race. Data were collected (1) directly from the patient at intake into the study and then again in 2 mo, (2) from the medical record, and (3) from the physician. Variables included background information, symptomatology, satisfaction with care, attitudes, use of medical facilities, medications, diagnoses, compliance and physician's estimate of patient's compliance, current health, and whether improvement was expected. A 2 x 2 factorial design was used to compare diabetic and nondiabetic patients with good and poor perceptions of health. Diabetic patients who viewed their health as poor had significantly more clinic visits, greater symptomatology, and were less satisfied with the doctor-patient relationship. The physician's rating of health did not confirm that this group actually had poorer health than the diabetic patients who perceived their health as good, and there was no difference in number of diagnoses between these groups. Data suggest that self-health perception is an important variable in diabetic patients. For those who see their health as poor, there may be a lack of concordance between patient and physician, which may result from these patients being more negativistic and difficult to treat. This may represent a group for whom a different type of treatment approach is needed.
A Case of Complete Transposition of the Viscera With Electrocardiographic and X-Ray Studies
Authors: AARON E. PARSONNET
Journal: Annals of Internal Medicine (1929)

Article1 March 1929A Case of Complete Transposition of the Viscera With Electrocardiographic and X-Ray StudiesAARON E. PARSONNET, M.D., F.A.C.P.AARON E. PARSONNET, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-2-9-963 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTransposition of the viscera, although not a rare condition, is interesting. Reports of such cases serve a very useful purpose of putting the physician on guard for these anomalies. To the surgeon, and needless to say, to the patient, a timely diagnosis of visceral transposition is obviously of the greatest importance.This case came under my observation through the courtesy of Dr. Samuel Roth, of Newark, and holds absolutely true to type as proven by physical findings, electrocardiograms, and X-ray studies.History: L. F., aged 35, well developed, overnourished white male, was seen by me on May 30, 1928, with... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Beth Israel Hospital Newark, New Jersey PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDarwin's Pangenesis and Medical Genetics 1 March 1929Volume 2, Issue 9Page: 963-967KeywordsElectrocardiographySurgeons Issue Published: 1 March 1929 PDF DownloadLoading ...
German Developments in Teaching Psychosomatics and Psychotherapy to Medical Students
Authors: Adolf-Ernst Meyer
Journal: Psychotherapy and Psychosomatics (1979)

The necessities for a reform of teaching German medical students were manifold. With the help of those doctors responsible for primary care and by founding a society representing all behavioural scientists within medical teaching it was possible to firmly institutionalize psychosomatics and psychotherapy within the new Medical Approbation Law. It is too early to assess the impact of this drastic reform but some of its advantages are already obvious.
Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial
Authors: David Michelson, Ellen Snyder, Erin Paradis, Mary Chengan-Liu, Duane B Snavely, Jill Hutzelmann, James K Walsh, Andrew D Krystal, Ruth M Benca, Martin Cohn, Christopher Lines, Thomas Roth, W Joseph Herring
Journal: The Lancet Neurology (2014)
Overexpression of C-NEU and C-MET during rat liver cholangiocarcinogenesis: A link between biliary intestinal metaplasia and mucin-producing cholangiocarcinoma
Authors: Svetlana Radaeva, Andrea Ferreira-Gonzalez, Alphonse E. Sirica
Journal: Hepatology (1999)

Based on limited but compelling immunohistochemical data demonstrating individual overexpression of the tyrosine kinase growth factor receptors, c–erbB–2 and c–met, in significant percentages of human cholangiocarcinoma (ChC), we investigated if combined overexpression of both c–neu, the rat homologue of c–erbB–2, and c–met, the receptor for hepatocyte growth factor/scatter factor (HGF/SF), might represent a characteristic, early event associated with furan–induced cholangiocarcinogenesis in rat liver. Specifically, through the use of immunohistochemistry, in situ hybridization (ISH), and Western and Northern blotting, we found that both c–neu and c–met are prominently overexpressed in intestinal metaplastic lesions in early putative precancerous cholangiofibrotic tissue formed in the livers of rats after 6 weeks of furan treatment when compared with normal and hyperplastic intrahepatic biliary epithelia. We further demonstrated that c–neu and c–met are concordantly overexpressed in neoplastic glandular epithelia in later–developed primary “intestinal–type” of ChC formed in the livers of furan–treated rats, as well as in subsequently derived transplantable mucin–producing tumors. Overexpression of c–neu and c–met correlated with increased proliferating cell nuclear antigen (PCNA)–labeling indices, which were determined to be three to four times higher in intestinal metaplastic glands in precancerous cholangiofibrotic tissue and in neoplastic glands in the primary “intestinal type” of ChC than in hyperplastic bile ductular structures within either cholangiofibrotic or bile duct-ligated (BDL) livers. The c–neu and c–met receptor proteins overexpressed in different in vivo passages of a transplantable ChC each contained immunoreactive phosphotyrosines, indicating an activated state. However, we did not detect evidence of either gene amplification of c–neu or c–met or of a common transmembrane–activating mutation in c–neu expressed in transplantable ChC. Our findings indicate that altered expression of c–neu and c–met occurs relatively early in the process of furan–induced cholangiocarcinogenesis in rat liver and may play a potentially important role in its pathogenesis. They further indicate a common alteration in tyrosine kinase growth factor receptor expression linking early putative precancerous intestinal metaplastic lesions in liver to later–developed mucin–producing biliary cancer.
Cardiovascular remodeling is greater in isolated systolic hypertension than in diastolic hypertension in older adults: the Insufficienza Cardiaca negli Anziani Residenti (ICARE) a Dicomano Study
Authors: Riccardo Pini, M.Chiara Cavallini, Francesca Bencini, Gabriella Silvestrini, Elisabetta Tonon, Walter De Alfieri, Niccolò Marchionni, Mauro Di Bari, Richard B Devereux, Giulio Masotti, Mary J Roman
Journal: Journal of the American College of Cardiology (2002)
Abnormal platelet von willebrand factor interaction in patients with TTP
Authors: G. Rock, P. Tittley, J. R. Taylor
Journal: American Journal of Hematology (1988)

Thrombotic thrombocytopenic purpura (TTP) is associated with abnormal platelet function and disturbances in coagulation; however, a specific causative factor is not defined. Plasma infusion or plasma exchange (PE) are thought to be of benefit in replacing a deficient plasma component or removing some toxic compound. In three patients with TTP, samples taken prior to initiation of PE showed high levels of vWF:Ag in the plasma (208, 264, and 321 U/dl), whereas the VIII:C levels were normal. The vWF:Ag multimer patterns of the plasma demonstrated a decrease in the amount of high molecular weight (HMW) forms. Analysis of the platelets from one patient also showed an increase in the HMW multimers. Platelets from all three patients showed a decreased ability to absorb vWF:Ag, with little or no absorption of the HMW forms. Following extensive PE and resolution of disease, the platelets regained their ability to absorb vWF:Ag in the one patient examined.
Hazard screening of chemical releases and environmental equity analysis of populations proximate to toxic release inventory facilities in Oregon.
Authors: C M Neumann, D L Forman, J E Rothlein
Journal: Environmental Health Perspectives (1998)

A comprehensive approach using hazard screening, demographic analysis, and a geographic information system (GIS) for mapping is employed to address environmental equity issues in Oregon. A media-specific chronic toxicity index [or chronic index (CI)] was used to compare environmental chemical releases reported in the EPA's Toxic Chemical Release Inventory (TRI) database. In 1992, 254 facilities reportedly released more than 40 million pounds of toxic chemicals directly into the environment on-site or transferred them to sewage treatment plants or other off-site facilities for disposal and recycling. For each reported on-site TRI chemical release, a CI based on oral toxicity factors and total mass was calculated. CIs were aggregated on a media-, facility-, and chemical-specific basis. Glycol ethers, nickel, trichloroethylene, chloroform, and manganese were ranked as the top five chemicals released statewide based on total CI. In contrast, based on total mass, methanol, nickel, ammonia, acetone, and toluene were identified as the top five TRI chemicals released in Oregon. TRI facility rankings were related to the demographics and household income of surrounding neighborhoods using bivariate GIS mapping and statistical analysis. TRI facilities were disproportionately located in racial and ethnic minority neighborhoods. They were also located in areas with lower incomes compared to those in the surrounding county. No relationship was observed between the hazard ranking of the TRI facilities overall and socioeconomic characteristics of the community in which they were located.
EXPERIMENTAL GONOCOCCUS INFECTION OF THE CHICK EMBRYO
Authors: Frederik Bang
Journal: The Journal of Experimental Medicine (1941)

1. The reaction of the chick embryo to nine strains of gonococci was studied. Four of these were inoculated intra-amniotically in 14 to 15 day embryos. 2. Infection of the 10 day chorio-allantoic membrane was localized and accompanied by polymorphonuclear leucocytic phagocytosis. 3. Infection was either transitory or persisted until hatching. Several strains killed the 10 day embryo in 3 days. 4. Chicken immune sera placed on the infected membranes failed to affect phagocytosis. 5. Slight sinusitis, bronchitis, and infection of the pulmonary alveoli were common following intra-amniotic injection of 14 to 15 day embryos. Infection also extended to the pulmonary and abdominal air sacs. 6. Serial passage on the membrane so modified one strain that it killed a greater percentage of both 10 day and 14 day embryos. The infection after modification was also accompanied by bacteremia and meningitis in one embryo. 7. The ability of meningococci to invade tissue and produce septicemia is contrasted with the inability of gonococci to produce more than a superficial infection. 8. The infection of the embryo with gonococci reproduces all of the essential characteristics of the disease in man. 9. Gonococci were found within columnar epithelial cells in a case of acute human urethritis.
Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome
Authors: Christa E Flück, Toshihro Tajima, Amit V Pandey, Wiebke Arlt, Kouji Okuhara, Charles F Verge, Ethylin Wang Jabs, Berenice B Mendonça, Kenji Fujieda, Walter L Miller
Journal: Nature Genetics (2004)
Type I and Type IV Allergy in Contact Dermatitis
Authors: N. Hjorth, D. S. Wilkinson
Journal: British Journal of Dermatology (2006)

Journal Article Type I and Type IV Allergy in Contact Dermatitis Get access N. Hjorth, N. Hjorth Department of Dermatology Amtssygehuset, DK. 2900, Hellerup, Denmark Search for other works by this author on: Oxford Academic Google Scholar D. S. Wilkinson D. S. Wilkinson Wycombe General Hospital High Wycombe Bucks Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 88, Issue 1, 1 January 1973, Pages 103–105, https://doi.org/10.1111/j.1365-2133.1973.tb06685.x Published: 01 January 1973
Identification and Measurement of Plasticizer in Neonatal Tissues after Umbilical Catheters and Blood Products
Authors: Laura S. Hillman, Sally L. Goodwin, William R. Sherman
Journal: New England Journal of Medicine (1975)

Because of concern about tissue uptake of pasticizers used in medical equipment, di-(2-ethylhexyl) phthalate was measured by gas chromatography-mass spectrometry in neonatal heart and gastro-intestinal tissue. Seventeen infants who had umbilical catheterization alone or with administration of blood products, and 13 stillborn or older controls were studied. The mean levels of the plasticizer for heart residue and pressed extract in the study group --1.27 plus or minus 0.42 and 0.66 plus or minus 0.22 mug per gram respectively--were significantly (pgreater than 0.005) higher than the corresponding control levels (less than 0.07 plus or minus 0.03 and less than 0.07 plus or minus 0.04 mug per gram). Higher levels were associated with larger amounts of blood products, more extensive use of catheters, and early death. Levels in gastrointestinal tissue from three infants who had died of necrotizing enterocolitis were significantly (less than 0.05) higher than those in gastrointestinal tissue from infants without this disease. Thus, plasticizer from medical use of plastics does accumlate in tissues of critically ill infants.
Reperfusion arrhythmias after chronic regional denervation of the ischaemic myocardium in pigs
Authors: J. Cinca, F. Worner, A. Carreno, A. Bardaji, A. Salas-Caudevilla, J Soler-Soler
Journal: Cardiovascular Research (1992)

Objective: The aim was to assess the effects of chronic regional denervation of the ischaemic myocardium on reperfusion arrhythmias in a model with sparse coronary collateral circulation. Methods: Baseline ventricular refractoriness and epicardial activation times were measured together with reperfusion arrhythmias after 15 min (I-15′) or 30 min (I-30′) of left anterior descending coronary artery occlusion in 38 barbiturate anaesthetised open chest pigs. Twenty pigs (11 in I-15′ and nine in I-30′) had a chronic (two week) denervation of the left anteroseptal region, whereas 18 pigs (10 in I-15′ and eight in I-30′) were sham operated (non-denervated) controls. Denervation was induced by pericoronary application of phenol and verified by absence of adrenergic histofluorescence. Results: As compared with controls, denervated pigs showed: (1) longer activation times: 20.3(SD 5.2) ms v 16.5(4.6) ms, p<0.001; (2) slightly longer refractory periods: 348(28) ms v 334(27) ms; (3) a tendency to lower postreperfusion ectopic activity: ectopic beats ÷ time free of ventricular tachycardia: 0.13(0.19) v 0.34(0.40) in I-15′, and 0.21(0.24) v 0.39(0.44) in I-30"; (4) slower ventricular tachycardia in I-30′: 140(29) beats·min−1v 185(29) beats·min−1, p<0.009; and (5) comparable incidence of postreperfusion ventricular fibrillation: 4/11 pigs v 2/10 in I-15′, and 5/9 v 4/8 in I-30′. Conclusions: Selective chronic denervation of the ischaemic myocardium was unable to protect against malignant reperfusion arrhythmias in hearts with humanlike coronary collaterals. This was confirmed at two ischaemic periods known to produce progressive catecholamine accumulation and increased adrenoceptor density in the ischaemic myocardium. Cardiovascular Research 1992;26:962–967
Learning Problems— Interdisciplinary Approach
Authors: Lawrence J. Lawson
Journal: JAMA (1967)

To the Editor:—  The child who has difficulty learning in school is attracting great concern from pediatricians, ophthalmologists, neurologists, educators, psychologists, and even governmental agencies, plus nonmedically trained personnel. How can these children be identified, and what measures are of value in aiding these children? Each discipline has its own theories and projects, but the child can benefit most from an interdisciplinary approach. The activities of each specialist must be coordinated with an understanding of the others' findings, and the language and test results must be uniformly understood, so that a cooperative effort can be instituted to salvage these children. There are too many cultists operating in our communities who promise to aid these children through a series of treatments that most parents cannot afford. The parents are anxious to cooperate in any manner to correct the problem and are especially gullible to those who offer a sure-fire method of
Motor neurone disease: can we do better? A study of 42 patients
Authors: B. A Thornley
Journal: BMJ (1984)

Pustulotic arthro-osteitis probably associated with retroperitoneal fibrosis has been diagnosed in Erasmus of Rotterdam, based on paintings of Quentin Massys (1517) and Hans Holbein the younger (1523), historical letters of Erasmus, and postmortem examination of the skeleton. This case report is a description of the earliest known case of pustulotic arthro-osteitis, a syndrome reported for the first time in 1967 and seen more commonly in Japan than in Europe. Works of art of many different kinds may provide an important source of evidence of disease and contribute to a better understanding of the natural history of a disease.
Effect of Heart Rate on Aortic Insufficiency as Measured by a Dye-Dilution Technique
Authors: HOMER R. WARNER, ALAN F. TORONTO
Journal: Circulation Research (1961)

Measurements of the distance a labeled particle of blood travels back up the descending aorta during a single diastole have been carried out at two different heart rates in each of three patients with aortic insufficiency. From these measurements, the ratios of back flow per unit time at the slow heart rate to backflow at the faster heart rate were found to be 1.61, 1.71, and 1.75. From an analysis of the hemodynamic factors involved, it seems likely that backflow is overestimated at the slow heart rates by this technique due to the development of laminar flow late in diastole.
CARDIO-ESOPHAGEAL RELAXATION
Authors: S. A. ROBINS
Journal: JAMA (1926)

In our studies of the gastro-intestinal tract during the last three years, we have noticed under the fluoroscope a reflux of the barium meal from the stomach into the esophagus. As a result of this observation we have attempted to investigate this type of case with particular reference to its possible etiology and symptomatology. At first it was observed fluoroscopically only, with the patient in the prone position. In studying our old plates we have found some with the lower portion of the esophageal wall outlined with barium. Presumably we have missed or paid no attention to it heretofore. But since our attention has been called to it, we have found this condition in a larger percentage of cases, now 4.6 per cent, and have succeeded in demonstrating it on plates. Roentgenologically, in normal cases the barium column is considerably narrowed at the epicardia, and there is a momentary delay
486 IDIOSYNCRATIC DRUG-INDUCED LIVER INJURY (DILI) IN PATIENTS WITH PRE-EXISTING LIVER DISEASE: AN ANALYSIS OF THE CASES INCLUDED IN THE SPANISH DILI REGISTRY
Authors: N. Ortiz López, B. García-Muñoz, Y. Borraz, M. Roble, A. Castiella, M.D.C. Fernandez, R. Perez-Alvarez, S. Blanco, S. Ávila, M.I. Lucena, R.J. Andrade
Journal: Journal of Hepatology (2011)