tbuckley/cabot-search huggingface dataset:
Abstract 53: Tumor-associated macrophage promotes oral cancer progression through activation of Axl signal pathway
Authors: Yi-Shing Shieh, Chien-Hsing Lee, Chi-Kang Chen, Yu-Ting Chou
Journal: Cancer Research (2012)

Abstract Activation of the receptor tyrosine kinase Axl by its ligand gas6 is implicated in several diseases included inflammation and cancer. Our previous report demonstrated that Axl signal promotes oral squamous cell carcinoma (OSCC) carcinogenesis and progression. Recent studies also suggest that tumor-associated macrophage (TAM) promote tumor growth and metastasis. This study aims to study the potential involvement of Axl signal in the protumoral effect of TAM. We carried out coculture experiment by incubation of oral cancer cells (YD38) and macrophages (THP1). The expression of gas6 and Axl were examined in both cells. Characterized gene expression for M1 and M2 macrophage and EMT gene for cancer were also examined. The effect of Axl signal on cancer cells were further investigated by knockdown Axl expression and neutralized gas6 antibody in coculture system. The association Axl activation (pAxl) and TAM distribution were analyzed by Immunohistochemistry in cancer tissues. Our data indicated that upon coculture with cancer cells, TAM polarized to M2 phenotype with high IL10/low IL12 expression and elevated in gas6 secretion. After coculture with TAM, activation of Axl signal in cancer cells was noted. Furthermore, cancer increased mesenchymal markers expression and invasion/migration ability. While neutralzied gas6 or knockdown Axl, the coculture effects was diminished. In addition our result also demonstrated gas6/Axl signal elevated MMP-2 and -9 through NF-kb pathway to promote tumor invasion/migration, in which coculture of TAM increased NF-kb nuclear translocation and its bonding to MMPs promoter in cancer cells. Finally, in vivo cancer tissues showed significant association between TAM distribution and Axl (phosphorylated) expression. In conclusion, our results showed that TAMs play a protumor role in OSCC. TAM activated Axl signal and promoted tumor progression through NF-kb pathway. Therefore, Gas6/Axl and NF-kb signals in OSCC could be a putative target for therapeutic intervention. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 53. doi:1538-7445.AM2012-53
Automated Telephone Screening Survey for Depression
Authors: Lee Baer
Journal: JAMA (1995)

<h3>Objective.</h3> —To test the application of fully automated telephone screening using computerized digital voice recordings and touch-tone responses to assess symptoms of depression. <h3>Design.</h3> —A cross-sectional study of a 2-week-long telephone survey. <h3>Setting.</h3> —Toll-free telephone calls placed from home, work, or school to a central telephone/computer system at a telecommunications company in the Boston, Mass, area. <h3>Participants.</h3> —A total of 1812 participants called the system. Of these, 278 were students and faculty at a large midwestern state university, 725 were employees of a large northeastern high-technology firm, and 809 did not identify which site they were calling from. <h3>Main Outcome Measures.</h3> —The 20-question multiple-choice Zung Depression Scale was used to screen for depressive symptoms, and additional questions gathered demographic and caller satisfaction information. <h3>Results.</h3> —No technical problems were encountered during the trial. Of 1812 callers, 1597 (88.1%) completed all questions. Of these, 412 callers (25.8%) met criteria for "moderate or marked" depression and another 194 (12.1%) met criteria for "severe or extreme" depression. The majority of callers scoring positive for depression had received no previous treatment for depression. Of callers who completed the screening questionnaire, 74.6% reported the call to have been at least "moderately" helpful. <h3>Conclusion.</h3> —Readily available low-cost technology provides a fully automated, widely accessible, and confidential method of screening for a common mental illness. (<i>JAMA</i>. 1995;273:1943-1944)
Interaction of Body Mass Index and Framingham Risk Score in Predicting Incident Coronary Disease in Families
Authors: Samia Mora, Lisa R. Yanek, Taryn F. Moy, M. Daniele Fallin, Lewis C. Becker, Diane M. Becker
Journal: Circulation (2005)

Background— Siblings of individuals with premature coronary heart disease (CHD) have a marked excess risk of CHD risk factors and premature CHD. The impact of body mass index (BMI) on incident CHD in these families and the extent to which it may be mediated by associated risk factors are unknown. The aim of this study was to examine the effect of high BMI on incident CHD in white and black families with premature CHD and to estimate the heritability of BMI. Methods and Results— Risk factors, BMI, and Framingham Risk Score (FRS) were assessed at baseline and incident CHD was determined prospectively in 827 apparently healthy siblings of probands with premature CHD aged &lt;60 years. During a mean follow-up of 8.7 years, 13.3% of siblings had incident CHD events. Event rates were higher in obese and overweight siblings than in those with normal weight (15.3% and 16.0% versus 8.1%, respectively; P =0.01). Multivariable Cox proportional hazards analyses demonstrated the independent prognostic value of BMI when added to FRS ( P =0.02). A marked interaction between obesity (BMI ≥30 kg/m 2 ) and high FRS (&gt;20%) was seen for incident CHD ( P for interaction=0.008), with an adjusted hazard ratio compared with low-FRS/normal-weight siblings of 14.63 (95% CI, 6.40 to 33.44; P &lt;0.0001). BMI heritability (h 2 ) was moderate for whites and low for blacks (52% and 29%, respectively). Conclusions— High BMI contributed independently and significantly to incident CHD, beginning in the overweight range, and was most notable for obese siblings with a high-risk FRS.
Reply: Idiopathic Pulmonary Fibrosis: Perspectives on Clinically Meaningful Primary Endpoints in Phase 3 Clinical Trials
Authors: Ganesh Raghu, Harold R. Collard, Kevin J. Anstrom, Kevin R. Flaherty, Thomas R. Fleming, Talmadge E. King, Fernando J. Martinez, Kevin K. Brown
Journal: American Journal of Respiratory and Critical Care Medicine (2013)
The presence of painful fissures at altitude
Authors: J. Windsor
Journal: British Journal of Dermatology (2002)

Journal Article The presence of painful fissures at altitude Get access J. Windsor J. Windsor 12 Ashgate Road, Sheffield S10 3BZ, U.K Dr Jeremy Windsor. E‐mail: JSWINDSOR@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 147, Issue 6, 1 December 2002, Page 1262, https://doi.org/10.1046/j.1365-2133.2002.04954.x Published: 01 December 2002 Article history Accepted: 28 March 2002 Published: 01 December 2002
THE LEGAL STATUS OF THE TERM "REPUTABLE" AS APPLIED TO DENTAL COLLEGES.
Authors: Charles C Chittenden
Journal: JAMA (1902)

Uniformity of dental laws and standards in the various states of this country has been a consummation long sought and most devoutly wished by those men who have followed, as well as those who have dictated and guided, the development of our educational methods, with a view to placing the dental profession of this country where it rightfully belongs before the civilized world. <h3>UNIFICATION DIFFICULT.</h3> The comparative ease with which the legal right to establish and maintain schools and colleges in any state or territory is secured is only exceeded by the great difficulties that have presented in all attempts to unify methods, curricula and standards for the conferring of the dental degree. As schools increased in number, the estimated value of the dental diploma became more and more an unknown and uncertain quantity, which condition resulted in an effort toward the establishment by the people, through their legislative representatives,
Points: Gastrointestinal endoscopy in the young
Authors: J T Lawson
Journal: BMJ (1987)

In pheochromocytoma (PC12) cells nerve growth factor (NGF) and epidermal growth factor (EGF) activate similar receptor tyrosine kinase signaling pathways but evoke strikingly different biological outcomes: NGF induces differentiation and EGF acts as a mitogen. A novel approach was developed for identifying transcription factor activities associated with NGF-activated, but not EGF-activated, signaling, using random oligonucleotide clones from a DNA recognition library to isolate specific DNA binding proteins from PC12 nuclear extracts. A protein complex from NGF-treated, but not EGF-treated, cells was identified that exhibits increased mobility and DNA binding activity in gel mobility shift assays. The binding complex was identified in supershift assays as Fra-2/JunD. The clones used as probes contain either AP-1 or cAMP response element binding (CREB) recognition elements. Time course experiments revealed further differences in NGF and EGF signaling in PC12 cells. NGF elicits a more delayed and sustained ERK phosphorylation than EGF, consistent with previous reports. Both growth factors transiently induce <i>c-fos</i>, but NGF evokes a greater response than EGF. NGF specifically increases Fra-1 and Fra-2 levels at 4 and 24 hr. The latter is represented in Western blots by bands in the 40–46 kDa range. NGF, but not EGF, enhances the upper bands, corresponding to phosphorylated Fra-2. These findings suggest that prolonged alterations in Fra-2 and subsequent increases in Fra-2/JunD binding to AP-1 and CREB response elements common among many gene promoters could serve to trigger broadly an NGF-specific program of gene expression.
Recombinant long-acting glycoPEGylated factor IX in hemophilia B: a multinational randomized phase 3 trial
Authors: Peter W. Collins, Guy Young, Karin Knobe, Faraizah Abdul Karim, Pantep Angchaisuksiri, Claus Banner, Türkiz Gürsel, Johnny Mahlangu, Tadashi Matsushita, Eveline P. Mauser-Bunschoten, Johannes Oldenburg, Christopher E. Walsh, Claude Negrier
Journal: Blood (2014)
201 COPY NUMBER ALTERATIONS IN HEPATOCELLULAR CARCINOMA AND IDENTIFICATION OF NUCKS1 AS A PUTATIVE ONCOGENE ON CHROMOSOME 1Q32.1
Authors: J.Y. Cheong, S.S. Kim, D.K. Kim, M. Yeo, J.H. Woo, S.J. Yang, K.S. Yang, S.W. Cho
Journal: Journal of Hepatology (2011)
Hypertriglyceridaemia following adjuvant interferon-α treatment in two patients with malignant melanoma
Authors: None JUNGHANS, None RÜNGER
Journal: British Journal of Dermatology (1999)

Journal Article Hypertriglyceridaemia following adjuvant interferon‐α treatment in two patients with malignant melanoma Get access JUNGHANS, JUNGHANS Department of Dermatology, University of Göttingen, Von‐Siebold‐Strasse 3, 37075 Göttingen, Germany Search for other works by this author on: Oxford Academic Google Scholar RÜNGER RÜNGER Department of Dermatology, University of Göttingen, Von‐Siebold‐Strasse 3, 37075 Göttingen, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 140, Issue 1, 1 January 1999, Pages 183–184, https://doi.org/10.1046/j.1365-2133.1999.02640.x Published: 01 January 1999
Unilateral congenital dysplasia of lung associated with vascular anomalies
Authors: A. Hislop, M. Sanderson, L. Reid
Journal: Thorax (1973)

<b>Hislop, A., Sanderson, M., and Reid, L. (1973).</b><i>Thorax</i>, <b>28</b>, 435-441. <b>Unilateral congenital dysplasia of lung associated with vascular anomalies.</b> In three cases of unilateral lung dysplasia the structural changes have been analysed quantitatively to throw light on the nature of the anomaly and stage of its appearance. In one case the pulmonary artery was hypoplastic and the systemic supply normal but increased, suggesting onset in late intrauterine life or early childhood: in the other two cases the blood supply was only systemic, from both normal and abnormal arteries, suggesting onset in the early weeks of intrauterine development. Airway development was consistent with this interpretation. All cases had additional signs of maldevelopment of mesodermal tissue. The origin of the various types of systemic artery is discussed.
THE BACTERIOLOGY OF CYSTITIS.
Authors: R. C. LONGFELLOW
Journal: JAMA (1903)

vast prairies, or now in the bottom lands of our rivers and the swamps of the north and the south by the mos¬ quito alone ?Most certainly not !Especially when we take into consideration that it is a well-established fact that mosquitoes, as a rule, go but a short distance from their breeding places, sometimes but a few hundred feet-average distance not to exceed half of a mile-and that in olden times, and even now in our swamp regions, the settlements were and are, scattered-often with miles intervening between them-with but little if any communication one with another.Many of the experiments that have been made by in¬ vestigators in different parts of the world during the past few years, which are claimed to have established the mosquito as the only intermediate host in the trans¬ mission of malarial diseases, were of a similar char¬ acter to those made by the Cuban board on yellow fever, and are not conclusive.For it is well known that many persons living in malarial districts can be, and are, ex¬ posed year after year to every possible means of con¬ tracting malarial fever-through the atmosphere, water and the mosquito-and yet remain in perfect health; and that healthy persons from non-malarial districts can spend months where malarial fevers are prevailingmingling with the sick and being exposed to every pos¬ sible means of contracting the disease-and not have a symptom of malarial trouble.Thousands of persons living in malarial districts can testify to the truth of this.The writer, who has had years of experience living in malarial districts, both before and since he became a physician, can most positively vouch for the truth of every statement here made.
Lymphatic Mapping and Sentinel Node Biopsy in Breast Cancer-Reply
Authors: Charles Cox
Journal: JAMA (1997)

<h3>In Reply.</h3> —We recognize and applaud the original description and subsequent contributions of lymphatic mapping for both melanoma and breast cancer made by Dr Giuliano and colleagues. In their original report of the new technology,<sup>1</sup>Giuliano et al describe a success rate for identifying the sentinel lymph node of 65.5% (114 of 174 cases) using a blue dye-only technique. We would argue that if the learning curve for any new technique is so steep that after 174 cases a success rate of only 65.5% is obtained, it is unlikely that the new technology will be incorporated into the everyday practice of the surgeon. Thus, the technique had to be improved. The true test of any technology is whether others can replicate the results and incorporate the procedure into their practice. We have now performed more than 200 mappings for breast cancer and have been unable to duplicate the data on mapping
PULSATILE VERSUS STEADY COMPONENTS OF BLOOD PRESSURE AND THEIR RELATIONS WITH AORTIC STIFFNESS: A BONE TO PICK?
Authors: Panagiotis Xaplanteris, Charalambos Vlachopoulos, Gregory Vyssoulis, Ioanna Dima, Katerina Baou, Konstantinos Aznaouridis, Dimitrios Terentes-Printzios, Aikaterini Siama
Journal: Journal of the American College of Cardiology (2010)
Src Kinase Is a Novel Therapeutic Target in Lymphangioleiomyomatosis
Authors: Alexey Tyryshkin, Abhisek Bhattacharya, N. Tony Eissa
Journal: Cancer Research (2014)

Abstract Lymphangioleiomyomatosis (LAM) is a progressive cystic lung disease affecting some women with tuberous sclerosis complex (TSC). Sporadic LAM can develop in women without TSC, owing to somatic mutations in the TSC2 gene. Accumulating evidence supports the view of LAM as a low-grade, destructive, metastasizing neoplasm. The mechanisms underlying the metastatic capability of LAM cells remain poorly understood. The observed behavior of LAM cells with respect to their infiltrative growth pattern, metastatic potential, and altered cell differentiation bears similarity to cells undergoing epithelial–mesenchymal transition. Here, we report increased levels of active Src kinase in LAM lungs and in TSC2−/− cells, caused by a reduction of autophagy. Furthermore, increased Src kinase activation promoted migration, invasion, and inhibition of E-cadherin expression in TSC2−/− cells by upregulating the transcription factor Snail. Notably, Src kinase inhibitors reduced migration and invasion properties of TSC2−/− cells and attenuated lung colonization of intravenously injected TSC2−/− cells in vivo to a greater extent than control TSC2+/+ cells. Our results reveal mechanistic basis for the pathogenicity of LAM cells and they rationalize Src kinase as a novel therapeutic target for treatment of LAM and TSC. Cancer Res; 74(7); 1996–2005. ©2014 AACR.
Cisapride and Fatal Arrhythmia
Authors: Diane K. Wysowski, Janos Bacsanyi
Journal: New England Journal of Medicine (1996)

To the Editor: From September 1993, the month in which the marketing of cisapride (Propulsid, Janssen Pharmaceutica, Titusville, N.J.) began, to April 1996, the Food and Drug Administration's MedWa...
TWO CASES OF BRAIN SURGERY WITH REMARKS.Read before the Northern Tri-State Medical Association at Hillsdale, Mich., Dec. 11, 1894.
Authors: HAL C. WYMAN
Journal: JAMA (1894)

<i>Case 1</i>.—A young woman, 23 years old, a teacher, had an attack of facial erysipelas, which started from a crack or cold sore in the alar aspect of the left nostril. Her face swelled and closed her eyes. The left ear became greatly swollen. The scalp of the forehead and left side of head was swollen and edematous to the crown. She suffered great pain, but no pus appeared in the parts, although she had a temperature ranging from 104 to 105 degrees F., for seven days. She took quinin and tincture of iron in doses of 2 grains and 7 drops respectively, during that time. The inflamed area was brushed with tr. iodin, reduced one-half with dilute alcohol, once a day. The left nostril was obstructed by swollen mucous membrane for three days, but it gave way under the daily use of an ointment made by rubbing 20 grains
TNFα-mediated extracellular matrix remodeling is required for multiple division cycles in rat hepatocytes
Authors: Anne‐Laure Sérandour, Pascal Loyer, Delphine Garnier, Brice Courselaud, Nathalie Théret, Denise Glaise, Christiane Guguen‐Guillouzo, Anne Corlu
Journal: Hepatology (2005)

During liver regeneration, hepatocytes proliferate under the control of both proinflammatory cytokines such as tumor necrosis factor α (TNFα) and growth factors, in parallel to extracellular matrix remodeling. This study investigated mechanisms by which mitogen and extracellular matrix signals are linked for inducing proliferation of differentiated hepatocytes. The authors used adult rat hepatocytes in coculture with liver biliary cells, because cells are stably differentiated for several weeks, capable of extracellular matrix deposition, and unable to divide in response to growth factor alone. This work demonstrated that hepatocytes could undergo several proliferation waves without loss of differentiation by using alternating periods of TNFα/growth factor stimulation and deprivation. Three days after stimulation with TNFα and epidermal growth factor (EGF), up to 35% of hepatocytes divided. Demonstration was also provided that EGF alone only promoted cell progression up to late G1, whereas TNFα was necessary for G1/S transition and Cdk1 induction. TNFα promoted an extracellular matrix (ECM) degradation that involved the matrix metalloproteinase MMP-9 induction through activation of NF-κB pathway. Finally, the authors showed that ECM remodeling signal was required for initiating any new hepatocyte division wave, in presence of mitogen. In conclusion, these results highlight that hepatocyte division is dependent on ECM deposition associated with differentiation status, and that ECM degradation signal is critical in controlling G1/S transition and Cdk1 induction. These results provide new insights for understanding the unique hepatocyte proliferation control and improving regeneration in patients suffering from liver damage. (HEPATOLOGY 2005;41:478–486.)
Book Review Comprehensive Management of Head and Neck Tumors Second edition. Edited by Stanley E. Thawley, William R. Panje, John G. Batsakis, and Robert D. Lindberg. 1981 pp. in two volumes, illustrated. Philadelphia, W.B. Saunders, 1999. $295. 0-7216-5582-3
Authors: John A. Ridge
Journal: New England Journal of Medicine (1999)
Application of Ultrasound in Medicine
Authors: Padmakar P. Lele
Journal: New England Journal of Medicine (1972)

The use of ultrasound as a valuable diagnostic aid in several fields of clinical medicine is now so well established that it can be considered essential to good patient care. Among the different diagnostic and therapeutic modalities used in clinical work ultrasound is unique in that all body tissues, except bone and air-filled lungs, are relatively permeable to ultrasonic energy, a millimeter or less in wavelength. This permits visualization, noninvasively and with adequate resolution, of even the deepest structures in the body (unless they are rendered inaccessible by overlying bone or air) with ultrasound at sufficiently low intensity levels, generally . . .
Assessing renal graft function in clinical trials: Can tests predicting glomerular filtration rate substitute for a reference method?
Authors: Christophe Mariat, Eric Alamartine, Jean-Claude Barthelemy, Jean-Pierre De Filippis, Damien Thibaudin, Patricia Berthoux, Blandine Laurent, Lise Thibaudin, François Berthoux
Journal: Kidney International (2003)
Reelin Mobilizes a VAMP7-Dependent Synaptic Vesicle Pool and Selectively Augments Spontaneous Neurotransmission
Authors: Manjot Bal, Jeremy Leitz, Austin L. Reese, Denise M.O. Ramirez, Murat Durakoglugil, Joachim Herz, Lisa M. Monteggia, Ege T. Kavalali
Journal: Neuron (2013)
Efficient differentiation and function of human macrophages in humanized CSF-1 mice
Authors: Chozhavendan Rathinam, William T. Poueymirou, Jose Rojas, Andrew J. Murphy, David M. Valenzuela, George D. Yancopoulos, Anthony Rongvaux, Elizabeth E. Eynon, Markus G. Manz, Richard A. Flavell
Journal: Blood (2011)
Night Calls: Their Frequency and Nature in One General Practice
Authors: J. H. F. Brotherston, A. Cartwright, J. L. Cowan, J. T. Baldwin, E. C. K. Douglas, G. A. Steele
Journal: BMJ (1959)

cmJoug 1169 reduces the tendency.Rosacea arising in patients other than women at the menopause is usually responsive to similar treatment.Body Odour Distress to the patient and offence to society may arise from body odour.This is very variable racially and individually and is influenced by sex, age, emotion, and by health and tone generally, as well as by diet.In the main it is dependent upon apocrine secretion and so upon sex hormones.It is the decomposition of apocrine sweat by surface organisms that is responsible for odour, so that cleanliness and care of underlinen is very important.In addition, shaving the axillae and 'the use of an antiseptic deodorant locally may be indicated.Hexachlorophane detergent 0.5 % is of value, as is a 25 % solution of aluminium chloride or a saturated solution of bicarbonate of soda (Shelley, 1953).It is doubtful if chlorophyll is a direct deodorant.The administration of oestrogens by mouth as suggested for acne, but in larger dosage, such as stilboestrol 1 mg.daily, appears sometimes to reduce apocrine activity.