tbuckley/cabot-search huggingface dataset:
Doctors and homosexuality
Authors: M. King
Journal: BMJ (1994)

Doctors want to know more ...

Editor,--Much as I welcome the debate about the difficulties for homosexual doctors,1 2 I am concerned on two accounts. Firstly, Lynn Rose bases her assertion that heterosexual doctors are prejudiced against their gay colleagues on data from open ended interviews with eight heterosexual doctors, none of whom were asked a question that directly addressed …
New European clinical trials directive
Authors: Allan Gaw, Moira M B Mungall
Journal: BMJ (2004)

Screening without evidence of efficacy Thyroid ultrasonography is another exampleEditor-I agree with Law's view of screening, that screening of unproved value should not be advocated. 1 As a clinical endocrinologist I often have to deal with patients' anxieties about non-palpable incidental findings on thyroid ultrasonography, often performed for wrong or unjustified reasons.Sometimes patients arrive with already established surgical complications after unnecessary thyroid operations.Although a substantial number of incidental thyroid nodules may be histologically malignant, 2 their clinical importance has never been proved.A recent preliminary study indicates that the progression rate of non-palpable proved thyroid malignant nodules to clinically significant lesions may be very low. 3 Thyroid ultrasonography is an additional example of an often used, often non-efficacious screening modality that may lead to "cascade iatrogenesis." 4
NON-INVASIVE STAGING OF AXILLA IN PATIENTS WITH BREAST CANCER USING Tc-99m SESTAMIBI AND DIFFERENT NUCLEAR MEDICINE TECHNIQUES - A PILOT PROJECT.
Authors: E. S. Delpassand, E. Singletary, M. I. Ross, F. C. Ames, K. Hunt, D. A. Podoloff
Journal: Clinical Nuclear Medicine (1999)

Scientific Abstracts And Posters From The 44Th Annual Meeting Of The Southwestern Chapter Of The Society Of Nuclear Medicine, And From The 12Th Northeastern Regional Scientific Meeting Of The New England And New York Chapters Of The Society Of Nuclear Medicine
Many third molar teeth are probably removed unnecessarily in Sandwell
Authors: V. Lopes
Journal: BMJ (1998)

EDITOR—Jones et al report their interview study to assess dentists' agreement on the treatment of asymptomatic impacted third molar teeth.1 They state that a quarter of these teeth are removed without being diseased, and give as a reference for this statement a paper by colleagues and myself; in fact the figure was half, not …
Epstein-Barr virus associated B-cell lymphoma of brain developing in myelodysplastic syndrome withc-kit mutation (Try-557 ? stop)
Authors: Yusuke Kuwahara, Ayumu Hirata, Hideaki Miwa, Satoru Munakata, Shuji Ueda, Yuzuru Kanakura, Motohiko Maruno, Tadashi Hongyo, Taisei Nomura, Katsuyuki Aozasa
Journal: American Journal of Hematology (2000)

The first case of B-cell lymphoma of brain in a patient with myelodysplastic syndrome (MDS) was reported. A 68-year-old man was admitted because of anemia, fever, and thrombocytopenia and was diagnosed as having MDS (refractory anemia with excess of blasts) on the basis of the findings of bone marrow aspiration and chromosomal analysis. The patient was followed up without chemotherapy, but a brain tumor appeared after 3 years. Histologic and immunohistologic examinations revealed diffuse large B-cell lymphoma. Mutations of the c-kit proto-oncogene (stem cell factor receptor) and the p53 tumor-suppressor gene were examined in the MDS lesion and malignant lymphoma (ML) by the polymerase chain reaction-single-strand conformational polymorphism (PCR-SSCP) method followed by direct sequencing. The p53 mutation was not found in either MDS or ML, but a nonsense mutation (Try-557 → stop) in exon 11 of the c-kit, which might lead to dysfunction of tyrosine kinase activity, was detected in MDS. This is the first report of c-kit mutation in MDS. Epstein-Barr virus (EBV) genome was demonstrated in the nucleus of brain ML cells by in situ hybridization with EBV-encoded RNA-1 probe. Immunohistochemistry showed that the tumor cells expressed latent infection gene products, including EBV nuclear antigen-2 and latent membrane protein-1. This pattern of latent gene expression was Lat III, which is usually found in malignant lymphomas developing in immunocompromised hosts. These findings suggest that a profound pancytopenia in MDS resulted in an immunodeficient condition, after which EBV-positive B-cell lymphoma of brain developed. Am. J. Hematol. 65:234–238, 2000. © 2000 Wiley-Liss, Inc.
ACTIVITY OF COMMERCIAL PREPARATIONS OF HOG'S STOMACH
Authors: J. F. Wilkinson
Journal: BMJ (1932)

Series C. Evidence of Synthalin being InactiveAnalysis of nine chianges when synthalin was added and blood sugar rose.Average total rise of blood sugar, 32 mg.per 100 cecm.(15.5 per cent. of previous level).Average previous level, 206 mg. per 100 c.cm. Number of patients, 9 (2 male, 7 female).
Adenovirus-Transduced Lung as a Portal for Delivering α-Galactosidase A into Systemic Circulation for Fabry Disease
Authors: Chester Li, Robin J. Ziegler, Maribeth Cherry, Michael Lukason, Robert J. Desnick, Nelson S. Yew, Seng H. Cheng
Journal: Molecular Therapy (2002)

Gene therapy efforts have focused primarily on the use of either the liver or skeletal muscle as depot organs for the production of a variety of therapeutic proteins that act systemically. Here we examined the lung to determine whether it could function as yet another portal for the secretion of proteins into the circulation. Fabry disease is caused by a deficiency of the lysosomal hydrolase alpha-galactosidase A, resulting in the abnormal deposition of the glycosphingolipid globotriaosylceramide (GL-3) in vascular lysosomes. Pulmonary instillation of a recombinant adenoviral vector (Ad2/CMVHI-alpha(gal)) encoding human alpha-galactosidase A into Fabry mice resulted in high-level transduction and expression of the enzyme in the lung. Importantly, enzymatic activity was also detected in the plasma, liver, spleen, heart, and kidneys of the Fabry mice. The detection of enzymatic activity outside of the lung, along with the finding that viral DNA was limited to the lung, indicates that the enzyme crossed the air/blood barrier, entered the systemic circulation, and was internalized by the distal visceral organs. The levels of alpha-galactosidase A attained in these tissues were sufficient to reduce GL-3 to basal levels in the lung, liver, and spleen and to approximately 50% of untreated levels in the heart. Together, these results suggest that the lung may be a viable alternate depot organ for the production and systemic secretion of alpha-galactosidase A for Fabry disease.
Treatment of Theophylline Overdose-Reply
Authors: Larry S. Dean
Journal: JAMA (1983)

<h3>In Reply.—</h3> In response to Dr Olson and co-workers' letter regarding our CASE REPORT of the woman who survived massive theophylline overdose without hemoperfusion, we find little disagreement. We are not necessarily advocating that theophylline overdose be treated without hemoperfusion or hemodialysis but do present a case in which it was treated safely without those modalities. Contrary to their comment that tests for determination of theophylline levels should be available in all hospitals, this just is not the case throughout the country. In north central Washington, there are numerous small hospitals scattered around a large geographic area that do not have all these studies available. In our hospital, tests for determination of theophylline levels obviously are available, but not on a 24-hour, around-the-clock basis at this time. The point we were making was that in some parts of the country, particularly in the more rural areas, certain laboratory studies may
Group B Streptococci: A Serious Threat to the Neonate
Authors: Martha Yow
Journal: JAMA (1974)

Within the past few years, group B streptococcal disease has become a major problem in many areas of the United States. There is no doubt that there has been a true increase in the incidence of neonatal disease resulting from group B streptococci. These organisms have been recognized as pathogenic for many years, but only recently have they emerged as a major threat to the newborn infant. Lancefield<sup>1</sup>first described these hemolytic streptococci as distinct from the group A hemolytic streptococci and other hemolytic streptococci when she developed precipitin-grouping tests in 1934. In 1942, Rantz and Kirby<sup>2</sup>called attention to human infection caused by the group B streptococci. Hood and associates,<sup>3</sup>in 1961, presented a strong case for the importance of these organisms in perinatal infection in both the infant and the mother. In 1964, Eickhoff et al<sup>4</sup>reported experience with group B streptococcal infections at
Apixaban reduced stroke and systemic embolism compared with warfarin in atrial fibrillation
Authors: Liviu Klein
Journal: Annals of Internal Medicine (2012)

ACP Journal Club17 January 2012Apixaban reduced stroke and systemic embolism compared with warfarin in atrial fibrillationLiviu Klein, MD, MSLiviu Klein, MD, MSUniversity of California San Francisco, San Francisco, California, USA (L.K.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-2-201201170-02002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationGranger CB, Alexander JH, McMurray JJ, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365:981-92. https://pubmed.ncbi.nlm.nih.gov/21870978Clinical Impact RatingsGIM/FP/GP: Cardiology: Hematology: Neurology: References1 Connolly SJ, Ezekowitz MD, Yusuf S, et al; RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361:1139-51. [PMID: 19717844] Google Scholar2 del Zoppo GJ, Eliasziw M. New options in anticoagulation for atrial fibrillation. N Engl J Med. 2011;365:952-3. [PMID: 21830960] Google Scholar3 Eerenberg ES, Kamphuisen PW, Sijpkens MK, et al. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation. 2011;124:1573-9. [PMID: 21900088] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of California San Francisco, San Francisco, California, USA (L.K.)This article was published at Annals.org on 3 January 2012. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRivaroxaban reduced stroke and systemic embolism compared with warfarin in nonvalvular AF Liviu Klein Metrics 17 January 2012Volume 156, Issue 2Page: JC1-2KeywordsAnticoagulantsAtrial fibrillationHemorrhageHemorrhagic strokeStrokeThrombin ePublished: 17 January 2012 Issue Published: 17 January 2012 CopyrightCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Abnormal Bone Scan in an Adult With Osteopoikilosis
Authors: Young-Sil An, Joon-Kee Yoon, Myoung-Hoon Lee, Chul-Woo Joh, Seok-Nam Yoon
Journal: Clinical Nuclear Medicine (2004)

Osteopoikilosis is rare, autosomal dominant bone disorder diagnosed by radiologic features. The findings include multiple small, circumscribed round areas of increased bone density distributed symmetrically in a periarticular location. The lesions cluster at the ends of long bones, around the acetabulum, and in the small bones of the hands and feet. Normal Tc-99m MDP uptake in osteopoikilosis on a bone scan may be used as a marker in distinguishing it from osteoblastic bone metastases, but there are a few previous reports of abnormal bone scan findings in osteopoikilosis among young patients. The authors describe a 40-year-old woman with osteopoikilosis characterized by classic radiologic findings and an abnormal bone scan.
REPORT ON THE HISTO-PATHOLOGY OF TWO CASES OF CUTANEOUS TUBERCULIDES, IN ONE OF WHICH TUBERCLE BACILLI WERE FOUND
Authors: J. M. H. MACLEOD, OLIVER S. ORMSBY
Journal: British Journal of Dermatology (1901)

Journal Article REPORT ON THE HISTO‐PATHOLOGY OF TWO CASES OF CUTANEOUS TUBERCULIDES, IN ONE OF WHICH TUBERCLE BACILLI WERE FOUND Get access J. M. H. MACLEOD, M.D., M.R.C.P., J. M. H. MACLEOD, M.D., M.R.C.P. Dermatological Laboratory, Charing Cross Hospital Medical School Search for other works by this author on: Oxford Academic Google Scholar OLIVER S. ORMSBY, M.D. OLIVER S. ORMSBY, M.D. Dermatological Laboratory, Charing Cross Hospital Medical School Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 13, Issue 10, 1 October 1901, Pages 367–380, https://doi.org/10.1111/j.1365-2133.1901.tb16342.x Published: 01 October 1901
Decreased oxidative stress in patients with idiopathic dilated cardiomyopathy one year after immunoglobulin adsorption
Authors: Ingolf Schimke, Johannes Müller, Friedrich Priem, Ingrid Kruse, Birgit Schön, Julia Stein, Rudolf Kunze, Gerd Wallukat, Roland Hetzer
Journal: Journal of the American College of Cardiology (2001)
Bacteriuria and Incontinence in Nursing Home Residents
Authors: Joseph G. Ouslander
Journal: Annals of Internal Medicine (1996)

Letters1 February 1996Bacteriuria and Incontinence in Nursing Home ResidentsJoseph G. Ouslander, MD, John Schnelle, PhD, and Gwen Uman, PhDJoseph G. Ouslander, MDJewish Home for the Aging; Reseda, CA 91335Search for more papers by this author, John Schnelle, PhDJewish Home for the Aging; Reseda, CA 91335Search for more papers by this author, and Gwen Uman, PhDJewish Home for the Aging; Reseda, CA 91335Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-3-199602010-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree that potentially bothersome ethical issues arise with conducting research in cognitively impaired nursing home residents and have previously outlined our approaches to these and other related issues [1, 2].We may not have been clear enough in stating our consent procedures for this study. We first assessed the potential participant's capacity to consent with input from nursing home staff. Because of the high prevalence of dementia among incontinent nursing home residents, written consent was obtained in most cases from a responsible proxy before the patient was enrolled in the study. The patients' assent was assessed as ...References1. Ouslander JG, Schnelle JF. Research in nursing homes: practical aspects. J Am Geriatr Soc. 1993; 41:182-7. Google Scholar2. Ouslander JG, Osterweil D, Morley J. Medical Care in the Nursing Home. New York: McGraw-Hill; 1991:367-76. Google Scholar Author, Article, and Disclosure InformationAuthors: Joseph G. Ouslander, MD; John Schnelle, PhD; Gwen Uman, PhDAffiliations: Jewish Home for the Aging; Reseda, CA 91335 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1996Volume 124, Issue 3Page: 373-374KeywordsDementiaHealth care qualityIncontinenceNursing homesQuality of life ePublished: 15 August 2000 Issue Published: 1 February 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Case 8-1973
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, Frank F. Davidoff, Austin L. Vickery
Journal: New England Journal of Medicine (1973)

Presentation of CaseA 48-year-old woman was admitted to the hospital because of hypoglycemia.She was in good health until one year previously, when she experienced for a period of two weeks episodes of confusion, blurred vision, numbness, tingling and cold sweats; the attacks generally occurred before breakfast or four hours after lunch and were relieved by the ingestion of food. She was seen by a psychiatrist and was treated for depression with imipramine hydrochloride and perphenazine. Six weeks before admission the attacks recurred, and a fasting blood glucose level of 32 mg per deciliter was found. Studies at another . . .
TIME TO INTRAVENOUS THERAPY AND CLINICAL OUTCOMES IN OLDER PATIENTS PRESENTING WITH ACUTE DECOMPENSATED HEART FAILURE: AN ANALYSIS OF THE ADHERE REGISTRY EMERGENCY MODULE
Authors: Yee Weng Wong, Gregg C. Fonarow, Xiaojuan Mi, Roger M. Mills, Frank W. Peacock IV, Lesley Curtis, Laura Qualls, Winslow Klaskala, Adrian F. Hernandez
Journal: Journal of the American College of Cardiology (2013)
Health Insurance and Preventive Care-Reply
Authors: Charles B. Arnold
Journal: JAMA (1988)

<h3>In Reply.</h3> —Dr Taylor's letter mentions a financial vexation that may occasionally accompany the practice of medicine in this era of group health insurance. Dr Taylor and I seem to agree, however, that prevention should be an active part of clinical medicine. Preventive services remain highly desirable, especially those that identify major clinical risk factors. I think most physicians agree that our patients need to be informed of the significance that focused screening and intervention can have on their health. An employee's benefit plan determines whether procedures such as screening physical examinations and mammograms will be covered. Apparently for the previously mentioned employee or dependent under Dr Taylor's care, the group health insurance plan did not provide such coverage for any elective services, such as preventive care, where charges to the patient may be a personal financial burden. As a general rule it is worthwhile to discuss whether the benefit
Human microRNA-27a* targets Prf1 and GzmB expression to regulate NK-cell cytotoxicity
Authors: Tae-Don Kim, Su Ui Lee, Sohyun Yun, Hu-Nan Sun, Suk Hyung Lee, Jae Wha Kim, Hwan Mook Kim, Song-Kyu Park, Chang Woo Lee, Suk Ran Yoon, Philip D. Greenberg, Inpyo Choi
Journal: Blood (2011)
Abstract 3335: The potential role of lateral inhibition in the maintenance of glioblastoma cancer stem cells
Authors: Kah Jing Lim, Charles G. Eberhart, Eli E. Bar
Journal: Cancer Research (2012)

Abstract Glioblastoma (GBM) is a malignant cancer of the central nervous system. Tumor cells are highly resistant to conventional therapies and tumors always recur. Cancer stem cells are thought to be critical for long-term growth and therapeutic resistance of GBM. It is therefore important to understand the signaling mechanisms maintaining GBM cancer stem cells. Notch is known to be an important signaling pathway during neural development, and can promote the maintenance of stem and progenitor cells via the process of lateral inhibition. Lateral inhibition is a contact-dependent signaling mechanism by which some cells within a field remain stem-like while others differentiate. In normal development, Notch ligands initiate this process by binding to the receptor on an adjacent cell, signaling to this neighbor to remain undifferentiated. Although Notch is known to be a critical player in the maintenance of stem-like cancer cells in various tumor types, including GBM, it is not known if the mechanism of lateral inhibition is also conserved in neural cancer stem cells. To test this hypothesis, we engineered a model system where isogenic cells expressing low and high levels of the Jag1 ligand are co-cultured followed by flow-based separation and determination of Notch pathway activity in each respective population. These experiments suggest that lateral inhibition is conserved in GBM. In the GBM neurosphere lines HSR-GBM1 and 040821, co-culture induced expression of Notch targets Hes5 and Hey1 in Jag1-low “signal receiving” cells and inhibited expression of these targets in Jag1-overexpressing “signal sending” isogenic cells. Preliminary experiments suggest that the ligand intracellular domain (ICD) is involved in this process. Our data suggest conservation of a developmental mechanism regulating Notch activation in cancer, and may affect our understanding of how to treat Notch-dependent tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3335. doi:1538-7445.AM2012-3335
Talks on US healthcare reforms are halted until autumn
Authors: B. Roehr
Journal: BMJ (2009)

Disagreement among Democrats in the US Congress has pushed back a vote on US healthcare reform bills until the autumn, despite a public relations blitz by President Barack Obama to add a sense of urgency to the effort.

President Obama held a series of public events and a news conference on health reform on 22 July, but his continuing focus on abstract principles rather than details of reform did little to convince members of focus groups watching the primetime broadcast.

Typical was his skirting of the issue of sacrifice and costs when he said that the American public are only “going to have to give up paying for things that don’t make them healthier.”

A Washington Post editorial said, “Mr Obama is right that sticking …
The Role of Physicians in Controlling Medical Care Costs and Reducing Waste
Authors: Robert H. Brook
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pruritus in Diabetes Mellitus: Investigation of Prevalence and Correlation With Diabetes Control
Authors: J B Neilly, A Martin, N Simpson, A C MacCuish
Journal: Diabetes Care (1986)

Three hundred diabetic and 100 nondiabetic hospital outpatients (both groups of comparable age and sex distribution) were assessed for the presence of generalized and localized pruritus. Pruritus vulvae was significantly more common in diabetic women (18.4%) than in controls (5.6%) and was significantly associated with poor diabetes control (mean glycosylated hemoglobin level less than 12%). Other forms of localized pruritus were equally common in diabetic and nondiabetic patients, regardless of glycosylated hemoglobin levels. Generalized pruritus was present in 14 diabetic patients, but in 5 cases the symptom was ascribed to intercurrent illness or drug administration. Thus, generalized pruritus without apparent cause was present in only 8 diabetic patients (2.7%) and was not significantly more common than in nondiabetic patients. It is doubtful if diabetes mellitus per se should be regarded as a cause of generalized or localized pruritus, other than pruritus vulvae.