tbuckley/cabot-search huggingface dataset:
FOUR CASES OF CONSUMPTION, IN WHICH THE PULMONARY DISEASE WAS ARRESTED OR CURED WITHOUT MARKED OR PERMANENT IMPROVEMENT OF THE GENERAL SYMPTOMS
Authors: T. Inman
Journal: BMJ (1854)

THIE following cases are interesting, as they serve as illus- trations that a person may die from consumption, notwith- -standing the cure of the condition of the lung upon which the disease is by some considered to depend.CASE i. Hugh Craney, aged 24, was admitted into the Northern Hospital, October 26th, 18.53.He was a carter, and had been much exposed to wet and cold.He had had consumptive symptoms for some time, and had been for three months during the previous winter in the infirmary.On admission, he was extremely weak and attenuated, had a severe cough and copious muco-purulent expectoration.Small caverns were detected under the left clavicle, and -also under the right.There was evidence, also, of a very large cavity a little above the right mamma.Shortly after his admission, he was seized with very severe hiemoptysis, and expectorated for two or three days .almost a pint of blood in the twenty-four hours.Sulphuric acid, acetate of lead and opium, and blisters to the chest, failed to make any impression upon the hvemoptysis.
Saatchi Bill is modified to try to get it through parliament
Authors: C. Dyer
Journal: BMJ (2014)

A new amendment to the Medical Innovation Bill that would require doctors to seek the opinion of experts outside their hospital before trying experimental treatments could ease the bill’s passage through parliament.

The bill, which had its second reading in the House of Lords on 27 June, is intended to encourage doctors to try untested treatments on patients for whom the accepted treatments have failed. It was sponsored by the Conservative peer Maurice Saatchi, whose wife, Josephine Hart, died from ovarian cancer.

Although the original bill was widely supported during public consultation, critics …
Variation in lateralization: Selected samples do not a population make
Authors: Terry E. Robinson, Jill B. Becker
Journal: Behavioral and Brain Sciences (1981)

The two major points of Denenberg's article are (1) that animals have lateralized brains, and (2) that the pattern of cerebral lateralization is consistent across species (i.e., “the left hemisphere will be primarily involved in communicative functions,” the right hemisphere with processing “spatial and affective information.” In addition, there is an unstated assumption that the pattern of lateralization is consistent within species. The evidence reviewed by Denenberg leaves little doubt that nonhuman animals have asymmetrically organized brains. However, there are problems with the suggestion that there is a consistent pattern of cerebral lateralization within or across different populations of species.
THE RATIO OF EARLY MITRAL INFLOW VELOCITY TO GLOBAL DIASTOLIC STRAIN RATE AS A POWERFUL PREDICTOR OF CARDIAC OUTCOMES IN PATIENTS WITH ATRIAL FIBRILLATION
Authors: Ho-Ming Su, Feng-Hsien Lin, Wen-Chol Voon, Wen-Ter Lai, Sheng-Hsiung Sheu
Journal: Journal of the American College of Cardiology (2014)
STRANGULATED FEMORAL HERNIA CONTAINING APPENDIX.REPORT OF TWO CASES.
Authors: J. HENRY BARBAT
Journal: JAMA (1904)

Strangulated femoral hernia with the appendix alone as the contents is of sufficient rarity to report. In the literature I find reports of about 100 cases in which the appendix was found in femoral herniæ, but in only a few of these was the appendix the sole occupant of the hernial sac, and in only one or two has a primary strangulation of the appendix occurred. In most cases the appendix was found as a passive occupant of the sac, sometimes accompanying the cecum in its descent, and at other times projecting through the ring with a separate loop of bowel or piece of omentum. In order that the appendix may pass through the hernial ring it must be free in the abdominal cavity and possess a meso-appendix sufficiently long and lax to allow its descent. No case has been reported in which the appendix was found in a left
Graduation for oldies
Authors: J. O. Drife
Journal: BMJ (2002)

Happier than funerals, less fraught than christenings, and cheaper than weddings, graduations are the most enjoyable of family milestones. They are also the most exclusive. With only two tickets per graduand and no black market, most of the family has to be content with the official video.

After years of gazing impassively over the audience as one of the gowned academics on the platform, it comes as a mild shock to find yourself in your Sunday …
Idiopathic Hypertrophic Subaortic Stenosis in Pregnancy
Authors: ALBERT J. KOLIBASH
Journal: Annals of Internal Medicine (1975)

The coexistence of pregnancy and idiopathic hypertrophic subaortic stenosis is a potentially dangerous combination. We report a 23-year-old white woman with idiopathic hypertrophic subaortic stenosis and pregnancy who presented with severe symptoms (Class IV) and modest outflow obstruction associated with marked mitral regurgitation. After delivery, the evidence for significant mitral regurgitation regressed, while the outflow obstruction seemed unchanged. However, she returned to Functional Class II. We review the mechanisms by which pregnancy and labor may alter the hemodynamics of idiopathic hypertrophic subaortic stenosis and we discuss recommendations for the management of these patients during pregnancy, labor, and the immediate postpartum period. We conclude that despite increasing symptoms, most women with diopathic hypertrophic subaortic stenosis can tolerate pregnancy and a vaginal delivery.
Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells.
Authors: T Matsuoka, Y Kajimoto, H Watada, H Kaneto, M Kishimoto, Y Umayahara, Y Fujitani, T Kamada, R Kawamori, Y Yamasaki
Journal: Journal of Clinical Investigation (1997)

Prolonged poor glycemic control in non-insulin-dependent diabetes mellitus patients often leads to a decline in insulin secretion from pancreatic beta cells, accompanied by a decrease in the insulin content of the cells. As a step toward elucidating the pathophysiological background of the so-called glucose toxicity to pancreatic beta cells, we induced glycation in HIT-T15 cells using a sugar with strong deoxidizing activity, D-ribose, and examined the effects on insulin gene transcription. The results of reporter gene analyses revealed that the insulin gene promoter is more sensitive to glycation than the control beta-actin gene promoter; approximately 50 and 80% of the insulin gene promoter activity was lost when the cells were kept for 3 d in the presence of 40 and 60 mM D-ribose, respectively. In agreement with this, decrease in the insulin mRNA and insulin content was observed in the glycation-induced cells. Also, gel mobility shift analyses using specific antiserum revealed decrease in the DNA-binding activity of an insulin gene transcription factor, PDX-1/IPF1/STF-1. These effects of D-ribose seemed almost irreversible but could be prevented by addition of 1 mM aminoguanidine or 10 mM N-acetylcysteine, thus suggesting that glycation and reactive oxygen species, generated through the glycation reaction, serve as mediators of the phenomena. These observations suggest that protein glycation in pancreatic beta cells, which occurs in vivo under chronic hyperglycemia, suppresses insulin gene transcription and thus can explain part of the beta cell glucose toxicity.
LUNG PERFUSION DEFECTS - EFFECT OF VASODILATORS
Authors: A R Ertle, D P Tashkin, M M Webber, M J Soffer, C W Frank
Journal: Clinical Nuclear Medicine (1984)

This investigation was undertaken to determine if vasodilator agents may enhance the diagnostic utility of perfusion lung imaging (Q) by normalizing regional perfusion abnormalities in bronchospastic patients. The effect of oxygen (02), nitroglycerine (NTG), hydralazine (H), and nifedipine (N) on regional lung perfusion defects was studied in 6 mild to severe asthmatics (ages 31–72 yrs) using sequential Kr-81m imaging which permits repetitive imaging due to very low radiation dose and 13 sec T-1/2. Each patient was studied once weekly for 3 wks. Baseline Q scans were obtained using 10mCi of I.V. Kr-8lm. The best view showing perfusion defects was used for subsequent images. At each visit 30% 02 by ventimask was given for 20 min followed by a repeat Q scan. Subsequently, on separate visits, subjects were given either 1 dose of sublingual (sl) N 20mg or 2 doses (1 hr between) of sl NTC 1/150gr or po H 25mg according to a random-order crossover design. Q scans were obtained 2 min after NTG, 60 min after H, and 30 and 60 min after N. 30% 02 was given again for 20 min, and a final scan was obtained. Scans were reviewed by 2 observers and showed relatively fixed defects in 4 pts improvement in defects in 3 pta with NTG, 1 with N, 1 with H, adn 2 with 02 alone. Additive effects of 02 and N or NTG were seen in 2 pts. These preliminary results suggest that vasodilators and 02 may improve regional perfusion in patients with bronchospastic disease and that this effect may be additive. Thus these medications, given prior to the perfusion scan, may improve its specificity for pulmonary embolism.
Methicillin-Resistant<i>Staphylococcus aureus</i>Abscess after Intramuscular Steroid Injection
Authors: Oliver P Gautschi, René Zellweger
Journal: New England Journal of Medicine (2006)

A 25-year-old bodybuilder was hospitalized with a painful left upper arm five days after injecting 1.5 ml of a steroid preparation into the medial aspect of his left biceps brachii muscle. He reported using a sterile needle obtained from a pharmacy, but the source of the steroid vial was unknown. At the injection site, there was a tender, erythematous, palpably fluctuant mass, 10 by 6 cm (Panels A and B). The level of creatine kinase was 18,100 U per liter, and the white-cell count was 20.6×103 per cubic millimeter. Computed tomography revealed a large abscess containing gas in the medial . . .
Diagonal Ear Lobe Crease is Associated with Epicardial Adipose Tissue Thickness and Carotid Intima Media Thickness in Subjects Free of Clinical Cardiovascular Disease
Authors: Sinan Şahin, Murat Ziyrek, Muammer Bilici, Levent Korkmaz, Zeydin Acar
Journal: Journal of the American College of Cardiology (2013)
Effects of protein kinase C activation on sodium, potassium, chloride, and total CO2 transport in the rabbit cortical collecting tubule.
Authors: S R Hays, M Baum, J P Kokko
Journal: Journal of Clinical Investigation (1987)

Several hormones induce phosphatidylinositol turnover in cell membranes and thus activate protein kinase C. Activation of protein kinase C can, in turn, have effects on epithelial transport. These experiments were designed to investigate the effects of two activators of protein kinase C, phorbol 12-myristate,13-acetate (PMA) and L-alpha-1,2-dioctanoylglycerol (L-alpha-1,2-DOG), and two inactive analogues, 4 alpha-phorbol and 4-O-methyl phorbol 12-myristate,13-acetate, on sodium, potassium, chloride, and total CO2 transport in the rabbit cortical collecting tubule. Utilizing in vitro microperfusion techniques, we found that activation of protein kinase C with either PMA or L-alpha-1,2-DOG significantly inhibited net sodium absorption, net potassium secretion and transepithelial voltage in a dose-dependent manner. There was no effect on net chloride or total CO2 transport. In contrast, the inactive phorbol analogues did not alter either sodium or potassium transport. These studies demonstrate that in the rabbit cortical collecting tubule sodium and potassium transport can be inhibited by compounds known to activate proteins kinase C. Thus, hormones that induce phosphatidylinositol turnover in the rabbit cortical collecting tubule may lead to inhibition of sodium transport by activation of protein kinase C.
Increased Pulmonary Vascular Resistance in the Dependent Zone of the Isolated Dog Lung Caused by Perivascular Edema
Authors: JOHN B. WEST, COLIN T. DOLLERY, BRIAN E. HEARD
Journal: Circulation Research (1965)

Measurements of the distribution of blood flow in an isolated dog lung made with radioactive xenon showed a great increase in vascular resistance in the dependent zone of the lung in the presence of a raised pulmonary venous pressure in some preparations. Evidence that this increased vascular resistance was caused by perivascular edema consisted of the general correlation with interstitial edema, the regional distribution of the effect, the sensitivity to the arteriovenous pressure difference, the effect of certain infusions particularly hypertonic urea, and the demonstration of edema around the small arteries and veins in rapidly frozen sections. The mechanism of the increased resistance is postulated as an interference with the tethering effect of the lung parenchyma which normally holds the vessels open. The possible role of this mechanism in the increased pulmonary vascular resistance of patients with pulmonary venous hypertension is discussed.
Educational Status and Active Life Expectancy among Older Blacks and Whites
Authors: Jack M. Guralnik, Kenneth C. Land, Dan Blazer, Gerda G. Fillenbaum, Laurence G. Branch
Journal: New England Journal of Medicine (1993)

Persons of low socioeconomic status are known to have reduced life expectancy. In a study of the relation of socioeconomic status to disability-free or active life expectancy among older persons, we analyzed prospectively gathered data on 2219 blacks and 1838 whites who were 65 years of age or older in the Piedmont region of North Carolina. We defined disability as the inability to perform independently one or more basic functional activities such as walking, bathing, dressing, eating, and using the toilet. For subgroups defined by sex, race, and education, statistical models were used to estimate, for persons at each year of age, the probability of transition from not being disabled or being disabled at base line to not being disabled, being disabled, or having died one year later. These transition probabilities were then entered into increment-decrement life tables to generate estimates of total, active, and disabled life expectancy (with total life expectancy equal to active life expectancy plus disabled life expectancy).
Effects of Dextrorotatory Triiodothyronine (D-T-3) on Lipid Metabolism in Human Subjects.
Authors: S. D. Splitter
Journal: Annals of Internal Medicine (1963)

s1 April 1963Effects of Dextrorotatory Triiodothyronine (D-T-3) on Lipid Metabolism in Human Subjects.S. D. Splitter, M.D. (Associate), M. B. Fine, M.D., G. D. Michaels, Ph.D., L. W. Kinsell, M.D., F.A.C.P.S. D. Splitter, M.D. (Associate)Search for more papers by this author, M. B. Fine, M.D.Search for more papers by this author, G. D. Michaels, Ph.D.Search for more papers by this author, L. W. Kinsell, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-723_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent publications indicate that thyroid and thyroid-like substances lower the level of plasma lipids and suggest that dextrorotatory isomers of some iodinated thyronines have proportionately greater effects upon lowering of plasma lipids than upon general metabolic stimulation.The present study was undertaken to (a) evaluate the effects of triiodothyronine upon plasma lipids in individuals with hyperlipidemia, (b) evaluate effects upon cholesterol synthesis in terms of rate of conversion of carbon-14 labeled mevalonic acid, and (c) evaluate rate of incorporation of C14 glucose in circulating glycerides (as an index of fatty acid synthesis from carbohydrate).Studies were carried out in ambulatory... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: S. D. Splitter, M.D. (Associate); M. B. Fine, M.D.; G. D. Michaels, Ph.D.; L. W. Kinsell, M.D., F.A.C.P.Affiliations: Oakland, Calif. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 723-723KeywordsBlood plasmaCarbohydratesCholesterolFatty acidsGlucoseHyperlipidemiaLipid metabolismLipidsThyroidTriiodothyronine ePublished: 1 December 2008 Issue Published: 1 April 1963 PDF downloadLoading ...
Farm‐derived <scp>G</scp>ram‐positive bacterium <i><scp>S</scp>taphylococcus sciuri </i><scp>W</scp>620 prevents asthma phenotype in <scp>HDM</scp>‐ and <scp>OVA</scp>‐exposed mice
Authors: S. Hagner, H. Harb, M. Zhao, K. Stein, O. Holst, M. J. Ege, M. Mayer, J. Matthes, J. Bauer, E. von Mutius, H. Renz, H. Heine, P. I. Pfefferle, H. Garn
Journal: Allergy (2013)

Abstract Background Farm‐derived dust samples have been screened for bacteria with potential allergo‐protective properties. Among those was S taphylococcus sciuri W 620 ( S. sciuri W620), which we tested with regard to its protective capacities in murine models of allergic airway inflammation. Methods We employed two protocols of acute airway inflammation in mice administering either ovalbumin ( OVA ) or house dust mite extract ( HDM ) for sensitization. Mechanistic studies on the activation of innate immune responses to S . sciuri W 620 were carried out using human primary monocytic dendritic cells (mo DC ) and co‐culture with autologous T cells. Results The allergo‐protective properties of S. sciuri W 620 were proven in a T H 2‐driven OVA model as well as in a mixed T H 1/T H 2 phenotype HDM model as demonstrated by abrogation of eosinophils and neutrophils in the airways after intranasal treatment. In the HDM model, lymph node cell T H 1/ T H 2 signature cytokines were decreased in parallel. Studies on human moDC revealed an activation of TLR 2 and NOD 2 receptors and initiation of DC maturation following incubation with S. sciuri W 620. Cytokine expression analyses after exposure to S. sciuri W 620 showed a lack of IL ‐12 production in mo DC due to missing transcription of the IL ‐12p35 mRNA . However, such DC selectively supported T H 1 cytokine release by co‐cultured T cells. Conclusion and clinical relevance Our proof‐of‐concept experiments verify the screening system of farm‐derived dust samples as suitable to elucidate new candidates for allergo‐protection. S . sciuri W 620 was shown to possess preventive properties on airway inflammation providing the basis for further mechanistic studies and potential clinical implication.
Effect of Intramuscular Injections on Serum Creatine Phosphokinase
Authors: Shelby Rose
Journal: JAMA (1973)

To the Editor.—  A recent communication,  Test—Effect of Intramuscular Injection in Myocardial Infarction (219:625, 1972), stressed the different agents that could augment creatine phosphokinase (CPK) activity. We wish to relate our experience with a recent patient who had elevated CPK values secondary to intramuscular injections of meperidine hydrochloride.  Report of a Case.—  A 43-year-old man was seen in the emergency room and had projectile vomiting, profuse sweating, and exquisite tenderness in the epigastrium and the right upper quadrant, but no rebound tenderness. Other systems yielded no abnormal findings.  The serum amylase level was 900 international units (IU) and an electrocardiogram was normal. Meperidine hydrochloride, 100 mg, was given intramuscularly. During the next 18 hours, he received two additional intramuscular injections of meperidine hydrochloride and one of penicillin. Enzyme studies were begun (Table). Significant laboratory findings with normal ranges included CPK activity, 750 IU (0 to 130); amylase level, 900
EVALUATION OF THE ASSOCIATION OF THE F2R IVS-14A/T PAR-1 POLYMORPHISM WITH STENT THROMBOSIS AND SUBSEQUENT CARDIOVASCULAR EVENTS IN A COHORT OF CORONARY ARTERY DISEASE PATIENTS
Authors: Donald Lynch, Jessica Delaney, Ehab Kasasbeh, Dan Roden, John Cleator
Journal: Journal of the American College of Cardiology (2012)
LOW INCIDENCE OF STENT THROMBOSIS IN ASIAN RACES: MULTICENTER REGISTRY IN ASIA SEVEN–YEARS FOLLOW–UP RESULTS
Authors: Sunao Nakamura, Hisao Ogawa, Jang-Ho Bae, Yeo H. Cahyadi, Wasan Udayachalerm, Damras Tresukosol, Sudaratana Tansuphaswadikul
Journal: Journal of the American College of Cardiology (2013)
Presidential Address ON RECENT ADVANCES IN THE STUDY OF CARDIO-VASCULAR DISEASE: Delivered before the Ulster Branch of the British Medical Association, November, 1924
Authors: J. E. MacIlwaine
Journal: BMJ (1925)

used withi the idea that tIme address may considerable amouint ofmatter whiclh has not its full practical utility.I shall hand, to discuss the questions manner as possible.The period taken being the term " recent " is merely defined period my owni graduation in medicine-twenty-three years.intended to give some points wvith regard history of the study of cardio-vascular permit more than a mention of namnes.I thlink it may be said that four years Harvey laid the basis of all real cardio-vascular disease.Before hiis timiie the views mechanismi i of the cieculation were so speculative from reality that it is difficult to-day conceive how ideas couild exist.Abouot a hluindred year-s ago auscultation definite ecogniition of the origin anid and second souinds of the hieart, qulestion murm'ursl was being tlioroughlly investigated.Just seventy years ago E. J. Mareyl began tih developmient his instrum-iienital methods, based upon air transmnission puulsation, a d opened up entirely groun d withi regard to the stucdy of cardio-vascilar Brooadbent's book oni the diseases the heart, published in 1897, miight be considered representative position of clinical cardiology jutst before the period terded di recent."I left tIme Royal Victoria Hospital thee beginininig of this periodl,havinig had, unlider Professor Lindsay, as good an opportuniity of aleaning g cardiac woork as any yoounig graduate could desiire.it is prooposed to conisider the recent adv-a.ncesundder four hleads : Advances in the study of the micchianisiii circulation.11. Advancees in kniow tledge of the f unctional activity of some of the organs of tlhe body, obtained by recent biochliemical mnethods.
Donors for Organ Transplants
Authors: Edward B. Shaw
Journal: JAMA (1969)

<h3>To the Editor:—</h3> American surgeons, in the selection and procurement of donors for organ transplants prefer donors (1) who have had complete cessation of central nervous system activity, (2) who are medically and legally dead, but (3) have continuing activity of the heart and circulation. This has quite naturally raised the dilemma of just when the donor patient is dead beyond moral or legal qualm. The French have the world's most perfect solution to this problem. The guillotine, which still exists in France, provides a donor in whom the precise instant at which cerebral function ceases is beyond doubt. Nor is there any possibility of restoration unless whole head transplant techniques improve. Tissues from such donors are maximally viable and any number of organs are ideally suitable for transplant. Donor and recipient could even be carefully matched in advance of the event which permits this generous contribution to surgical triumph.
Cerebral Venous Thrombosis
Authors: A Jaffer, D Leifer
Journal: New England Journal of Medicine (1997)

Figure 1. An 18-year-old woman presented three weeks post partum with a one-week history of headaches and two days of nausea, vomiting, and photophobia. On examination she was drowsy and had bilateral papilledema and a mild palsy of the right abducent nerve. A computed tomographic scan of the head was normal. Lumbar puncture revealed an opening pressure of 42 cm of water. A T1-weighted magnetic resonance image (Panel A) revealed high signal intensity in the straight sinus and the vein of Galen, findings compatible with thrombus (arrowheads). Magnetic resonance venography (Panel B) showed normal flow in the superior . . .