Odynophagia from Aphthous Ulcers of the Pharynx and Esophagus in the Acquired Immunodeficiency Syndrome (AIDS)
Authors: Michael C. Bach
Journal: Annals of Internal Medicine (1988)

Brief Reports15 August 1988Odynophagia from Aphthous Ulcers of the Pharynx and Esophagus in the Acquired Immunodeficiency Syndrome (AIDS)Michael C. Bach, MD, August J. Valenti, MD, Douglas A. Howell, MD, Thomas J. Smith, MDMichael C. Bach, MD, August J. Valenti, MD, Douglas A. Howell, MD, Thomas J. Smith, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-4-338 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNonspecific aphthous ulcers of the mouth are common in immunocompetent patients (1). The ulcers are self-limited, rarely progress to involve the hypopharynx or esophagus, and do not usually cause odynophagia. We describe the cases of three patients with the acquired immunodeficiency syndrome (AIDS) who developed severe odynophagia with progressive weight loss, resulting from multiple aphthous ulcers of the hypopharynx and esophagus. No infectious agents could be identified either by biopsy or from culture, and empiric antiviral and antifungal therapy were not effective. Corticosteroid therapy provided prompt and dramatic relief and healing in each patient.Patient 1Patient 1, an 18-year-old...References1. AntoonMiller JR. Aphthous ulcers—a review of the literature on etiology, pathogenesis, diagnosis and treatment. JADA. 1960;101:863-88. Google Scholar2. Weinstein W. The gastrointestinal tract as a target organ. In: Gottlieb MS, moderator. The acquired immunodeficiency syndrome. Ann Intern Med. 1983;99:208-20. MedlineGoogle Scholar3. WeberThornBarrisonUnwin JSIR. Cytomegalovirus colitis and esophageal ulceration in the context of AIDS: Clinical manifestations and preliminary report of treatment with Foscarnet (phosphonoformate). Gut. 1987;28:482-7. CrossrefMedlineGoogle Scholar4. KazlowKumudiniBenkovDischeLeLeiko PSKRN. Esophageal cryptosporidiosis in a child with acquired immune deficiency syndrome. Gastroenterology. 1986;91:1301-3. CrossrefMedlineGoogle Scholar5. RabeneckBoykoMcLeanMcLeodWong LWDWK. Unusual esophageal ulcers containing enveloped virus-like particles in homosexual men. Gastroenterology. 1986;90:1882-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Maine Medical Center, Portland, Maine; and the Swedish Hospital Medical Center, Seattle, Washington. For current author addresses, see end of text. 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II. Less common lesionsThalidomide hypersensitivity in AIDSOrofacial Pain in AIDS PatientsMajor aphthous-like ulcers in patients with AIDSEpstein-Barr virus associated oesophageal ulcers in AIDS.Thalidomide: Treatment of Severe Recurrent Aphthous Stomatitis in Patients with AidsRecurrent aphthous ulcer in patient infected with human immunodeficiency virus: Successful treatment with thalidomideUlcération pharyngée chez un patient atteint de SIDA : efficacité de la corticothérapieCorrection: Source of DataHerbert J. Kaufmann, MDOral manifestations of HIV diseaseAphthous Ulceration of the Gastrointestinal Tract in Patients with the Acquired Immunodeficiency Syndrome (AIDS)Michael C. Bach, MD, Douglas A. Howell, MD, August J. Valenti, MD, Thomas J. Smith, MD, Dean L. Winslow, MDRamsay-Hunt Syndrome in a Patient with HIV InfectionFunktionelle und elektrophysiologische Diagnostik bei DysphagieIdiopathic ulcer of the esophagus in the AIDS syndrome: a potential life-threatening complicationSI Units in HematologyThomas J. Spira, MD 15 August 1988Volume 109, Issue 4Page: 338-339KeywordsAIDSAntifungalsAntiviral therapyEsophagusHospital medicineInfectious diseasesMouthPharynxUlcersWeight loss Issue Published: 15 August 1988 PDF DownloadLoading ...