Cryptococcal Meningitis in the Acquired Immunodeficiency Syndrome (AIDS): Successful Treatment with Fluconazole after Failure of Amphotericin B
Authors: WILLIAM R. BYRNE
Journal: Annals of Internal Medicine (1988)

Brief Reports1 March 1988Cryptococcal Meningitis in the Acquired Immunodeficiency Syndrome (AIDS): Successful Treatment with Fluconazole after Failure of Amphotericin BWILLIAM R. BYRNE, M.D., CHARLES P. WAJSZCZUK, M.D.WILLIAM R. BYRNE, M.D.Search for more papers by this author, CHARLES P. WAJSZCZUK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-3-384 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCryptococcal meningitis, a common complication of the acquired immunodeficiency syndrome (AIDS), is usually associated with a high mortality (1) and the need for lifelong therapy with amphotericin B (2). Fluconazole is a recently developed triazole compound that acts againstCryptococcus neoformansin vitro, shows efficacy in an animal model of cryptococcal meningitis, and has good penetration into cerebrospinal fluid (3). Fluconazole therapy has been used successfully to treat a patient with AIDS who had a relapse of cryptococcal meningitis (4), when retreatment with amphotericin B and 5-flucytosine was contraindicated because of granulocytopenia. A determination of the relative efficacy of treatment...References1. KOVACSKOVACSPOLIS JAM. Cryptococcosis in the acquired immune deficiency syndrome. Ann Intern Med. 1985;103:533-8. LinkGoogle Scholar2. ZUGERLOUIEHOLZMANSIMBERKOFFRAHAL AERMJ. Cryptococcal disease in patients with the acquired immune deficiency syndrome: diagnostic features and outcome of treatment. Ann Intern Med. 1986;104:234-40. LinkGoogle Scholar3. PERFECTSAVANIDURACK JDD. Comparison of itraconazole and fluconazole in the treatment of cryptococcal meningitis and candida pyelonephritis in rabbits. Antimicrob Agents Chemother. 1986;29:579-83. CrossrefMedlineGoogle Scholar4. DUPONTDROUHET BE. Cryptococcal meningitis and fluconazole. Ann Intern Med. 1987;106:778. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Letterman Army Medical Center San Francisco, California Central Research Pfizer, Inc. Groton, Connecticut. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFungal Infections of the Central Nervous SystemFluconazole for the management of invasive candidiasis: where do we stand after 15 years?Cryptococcal Necrotizing Fasciitis With Multiple Sites of Involvement in the Lower ExtremitiesCentral Nervous System Infection in the Immunocompromised HostAspects actuels de la cryptococcose neuroméningée à AbidjanCRYPTOCOCCOSISCryptococcal Meningitis: Report of a CaseUse of Antifungal Therapy in Hospitalized Patients II. Results after the Marketing of FluconazoleCentral Nervous System Infection in the Immunocompromised HostOpportunistic/nosocomial infections. Treatment and developmental therapeutics. 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Dismukes, MDTreatment of systemic fungal infections: Recent progress and current problemsInfection in Relation to Thoracic Transplantation 1 March 1988Volume 108, Issue 3Page: 384-385KeywordsAIDSAmphotericinAnimal modelsAttentionCerebrospinal fluidCryptococcal meningitisCryptococcus neoformansMortality Issue Published: 1 March 1988 PDF DownloadLoading ...