tbuckley/cabot-search huggingface dataset:
A first report of collagenous gastritis, sprue, and colitis in a 9-month-old infant: 14 years of clinical, endoscopic, and histologic follow-up
Authors: K. Billiémaz, C. Robles-Medranda, C. Le Gall, C. Gay, O. Mory, A. Clémenson, R. Bouvier, G. Teyssier, A. Lachaux
Journal: Endoscopy (2009)

A 9-month-old boy was admitted to hospital with acute severe dehydration because of watery diarrhea. He had a history of low weight for height, due to chronic intermittent vomiting and diarrhea since 15 days from birth.
Peritoneal Dialysis for The Respiratory Distress Syndrome
Authors: P. J. Collipp
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Your recent article concerning hemodialysis (<b>202</b>:302, 1967) as a possible therapy for respiratory distress syndrome prompts me to describe our recent experience with peritoneal dialysis for this disease. Our first patient was a premature boy with birth weight 1.2 kg (2 lb 11 oz.). At age six hours his arterialized capillary blood<sub>p</sub>H was 7.16; Pco<sub>2</sub>, 95; and serum potassium level, 8.5 mEq/ liter. He had respiratory distress syndrome clinically and confirmed by chest roentgenogram. Peritoneal dialysis with a dialysis solution containing 1.5% glucose (and to which we added 5 mEq/liter of potassium) was begun promptly by the usual method. Aliquots of 60 ml were infused into the peritoneal cavity each hour and drained through a dialysis catheter at the end of each hour. Subsequent blood determinations were as follows: (at age nine hours)<sub>p</sub>H, 7.31; Pco<sub>2</sub>, 30; and potassium, 6.1 mEq/liter;
Fc gamma receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-gamma 1 and PLC-gamma 2 in natural killer cells.
Authors: A T Ting, L M Karnitz, R A Schoon, R T Abraham, P J Leibson
Journal: The Journal of Experimental Medicine (1992)

Crosslinking of the low affinity immunoglobulin G (IgG) Fc receptor (Fc gamma R type III) on natural killer (NK) cells initiates antibody-dependent cellular cytotoxicity. During this process, Fc gamma R stimulation results in the rapid activation of phospholipase C (PLC), which hydrolyzes membrane phosphoinositides, generating inositol-1,4,5-trisphosphate and sn-1,2-diacylglycerol as second messengers. We have recently reported that PLC activation after Fc gamma R stimulation can be inhibited by a protein tyrosine kinase (PTK) inhibitor. Based on the paradigm provided by the receptor tyrosine kinases, we investigated whether PLC-gamma 1 and/or PLC-gamma 2 are expressed in NK cells, and whether the PLC-gamma isoforms are tyrosine phosphorylated in response to Fc gamma R stimulation. Immunoblotting analyses with PLC-gamma 1- and PLC-gamma 2-specific antisera demonstrate that both isoforms are expressed in human NK cells. Furthermore, Fc gamma R crosslinking triggers the tyrosine phosphorylation of both PLC-gamma 1 and PLC-gamma 2 in these cells. Phosphorylation of both isoforms is detectable within 1 min, and returns to basal level within 30 min. Pretreatment with herbimycin A, a PTK inhibitor, blocked the Fc gamma R-induced tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2, and the subsequent release of inositol phosphates. These results suggest that Fc gamma R-initiated phosphoinositide turnover in human NK cells is regulated by the tyrosine phosphorylation of PLC-gamma. More broadly, these observations demonstrate that nonreceptor PTK(s) activated by crosslinkage of a multisubunit receptor can phosphorylate both PLC-gamma isoforms.
Abstract 3176: Connexin-43 facilitates breast cancer cell proliferation through upregulation of ERK-dependent beta-catenin, c-Myc and cyclin D1 expression
Authors: Yu Shih-Feng, Huang Tze-Sing
Journal: Cancer Research (2010)

Abstract Connexin-43 (Cx43) is one of the major components of gap junction which functions in maintaining cellular homeostasis. Despite Cx43 was reportedly deficient in several cancers such as glioma and colorectal cancer, its abnormally elevated expression was noted in the breast cancer tissues. In this study, we analyzed and detected differential Cx43 expression levels in three breast cancer cell lines: hs578T &amp;gt; MCF-7 &amp;gt; MDA-mB-231 cells. The same order was also observed with their growth rates, i.e., greatest in hs578T cells, followed by MCF-7 cells and then MDA-mB-231 cells. To explore if Cx43 was associated with breast cancer cell proliferation, we established Cx43-overexpressing clones from MCF-7 and MDA-mB-231 cells and found these cells obviously exhibited increased DNA synthesis and cell proliferation rates. We also cloned Cx43-knockdown hs578T cells and found their DNA synthesis and cell proliferation rates were significantly reduced. In these breast cancer cells, ectopic Cx43 overexpression was accompanied with up-regulation of β-catenin, phospho-ERK, c-Myc and cyclin D1 proteins, and vice versa. Furthermore, these Cx43-related increases of β-catenin, c-Myc, cyclin D1, and cell proliferation were drastically prevented by the inhibitor PD98059, suggesting that Cx43 overexpression induced β-catenin through ERK pathway, which in turn led to the increase of c-Myc and cyclin D1 to promote breast cancer cell proliferation. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3176.
Effects of Smoking
Authors: Frederick Lemere
Journal: JAMA (1964)

To the Editor:—  In The Problem of Tobacco Habituation ( JAMA  188: 932 [June 8] 1964), Dr. Chessick states that the smoking habit is based on a complex psychopharmacological reaction in which nicotine acts as an ego-alerting drug as well as a sympathetic nervous system stimulant. Nowhere, however, does he mention the relaxing effect so commonly recognized as one of the main attractions.  Relaxation is usually attributed to psychological pleasure, but if this is so, why are so many smokers dissatisfied with low-nicotine tobaccos, more effective filters, or puffing on a cigarette without inhaling? Obviously, the nicotinic drug effect is a primary ingredient of smoking pleasure, but could there be a tranquilizing effect as well? Most psychological theories are based on the concept of oral gratification and the deep incorporation (inhalation) of smoke into the lungs. Sucking on an empty pipe or an unlit cigarette may give oral gratification but it
Septicemia Due to<i>Proteus vulgaris</i>
Authors: Herbert L. Abrams
Journal: New England Journal of Medicine (1948)

THE term Proteus vulgaris (Bacillus proteus) refers to a number of different species of a gram-negative, actively motile rod form originally described in 1895.1 These organisms characteristically exhibit the "swarming" phenomenon in colonies on agar. They are widely distributed in contaminated soil and sewage and are found on the skin, in the urine and in the mouth.2 The Proteus organism was at first thought to be nonpathogenic, but Larson and Bell3 established its pathogenicity for rabbits, rats and guinea pigs in 1915. It has since been implicated in a large number of pathologic states, though its usual status is that . . .
Totally Endoscopic Robotically Enhanced Coronary Artery Bypass on the Beating Heart
Authors: Roberto P Casula, Thanos Athanasiou, Ashok Cherian, Ross Bacon, Rodney Foale, Ara Darzi
Journal: Journal of the Royal Society of Medicine (2003)

The introduction of telemanipulation systems has increased surgical dexterity and accuracy, providing seven degrees of freedom of motion, tremor filtration and three-dimensional visualization.1 With the aid of a new-generation articulated coronary stabilizer, cardiac surgeons are now able to perform completely endoscopic coronary artery bypass grafting without thoracotomy.2 At St Mary's Hospital we have used the Da Vinci Surgical System (Intuitive Surgical, Mountainview, CA). The surgeon works at a master unit where his/her hands movements are accurately reproduced by the slave instruments inside the chest. We report the first two UK cases.
The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus
Authors: Rachael Keating, Tomer Hertz, Marie Wehenkel, Tarsha L Harris, Benjamin A Edwards, Jennifer L McClaren, Scott A Brown, Sherri Surman, Zachary S Wilson, Philip Bradley, Julia Hurwitz, Hongbo Chi, Peter C Doherty, Paul G Thomas, Maureen A McGargill
Journal: Nature Immunology (2013)
Sermonizing by Psychiatrists
Authors: JONAS BRACHFELD
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 March 1982Sermonizing by PsychiatristsJONAS BRACHFELD, M.D.JONAS BRACHFELD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-3-384_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Articles such as the one by Dr. Jensen (1), usually written by a psychiatrist, appear with monotonous regularity. "Doctor-patient relationship are important, students are inadequately trained and not sufficiently interested to take heed of their importance, medicine is becoming mechanistic. . . ." Rather than repeating these conventional truths, a critical examination of the proposed causes and remedies that questions their validity might be more constructive.1. Student preparation. Is their any valid proof that students who do not have extensive background in science are more humane and socially oriented?2. Student selection. What is the evidence...Reference1. JENSEN P. The doctor-patient relationship: headed for impasse or improvement? Ann Intern Med. 1981;95:769-71. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rancocas Valley Hospital Willingboro, NJ 08046 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1982Volume 96, Issue 3Page: 384-384 ePublished: 1 December 2008 Issue Published: 1 March 1982 PDF downloadLoading ...
Polyclonal expansion of T cells with the TCR Vbeta type of the tumour cell in lesions of cutaneous T-cell lymphoma: evidence for possible superantigen involvement
Authors: T. Linnemann, S. Gellrich, A. Lukowsky, A. Mielke, H. Audring, W. Sterry, P. Walden
Journal: British Journal of Dermatology (2004)

Journal Article Polyclonal expansion of T cells with the TCR Vβ type of the tumour cell in lesions of cutaneous T‐cell lymphoma: evidence for possible superantigen involvement Get access T. Linnemann, T. Linnemann Department of Dermatology and Allergy, Charité—University Medicine Berlin, Humboldt University, Schumannstr. 20/21, D‐10117 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar S. Gellrich, S. Gellrich Department of Dermatology and Allergy, Charité—University Medicine Berlin, Humboldt University, Schumannstr. 20/21, D‐10117 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar A. Lukowsky, A. Lukowsky Department of Dermatology and Allergy, Charité—University Medicine Berlin, Humboldt University, Schumannstr. 20/21, D‐10117 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar A. Mielke, A. Mielke Department of Dermatology and Allergy, Charité—University Medicine Berlin, Humboldt University, Schumannstr. 20/21, D‐10117 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar H. Audring, H. Audring Department of Dermatology and Allergy, Charité—University Medicine Berlin, Humboldt University, Schumannstr. 20/21, D‐10117 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar W. Sterry, W. Sterry Department of Dermatology and Allergy, Charité—University Medicine Berlin, Humboldt University, Schumannstr. 20/21, D‐10117 Berlin, Germany Search for other works by this author on: Oxford Academic Google Scholar P. Walden P. Walden Department of Dermatology and Allergy, Charité—University Medicine Berlin, Humboldt University, Schumannstr. 20/21, D‐10117 Berlin, Germany Peter Walden. E‐mail: peter.walden@charite.de Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 150, Issue 5, 1 May 2004, Pages 1013–1017, https://doi.org/10.1111/j.1365-2133.2004.05970.x Published: 01 May 2004 Article history Accepted: 18 November 2003 Published: 01 May 2004
Pneumocystis carinii Pneumonitis Occurring in an Adopted Korean Infant
Authors: Bong Hak Hyun
Journal: JAMA (1966)

GENERALLY THOUGHT to be a protozoan,<i>Pneumocystis carinii</i>has been known for many decades to be the cause of a specific infection of the lung,<i>P carinii</i>pneumonitis. In Europe,<i>P carinii</i>pneumonitis is known to occur predominantly in debilitated and premature infants six weeks to a few months of age, and has been encountered primarily in epidemics in nurseries, resulting in many deaths.<sup>1,2</sup>Deamer and Zollinger<sup>3</sup>brought this condition to the attention of North American physicians in 1953. In 1956, Gagne and Hould<sup>4</sup>presented the first three cases from Canada and since then, an increasingly large number of cases have been recognized in the North American continent. The condition had not been reported in the Far East until 1959, when Lim<sup>5</sup>recorded an epidemic of 30 cases in infants occurring in a Korean orphanage. In 1960, Lim and Moon<sup>6</sup>presented epidemiologic and clinical studies
A novel biologic activity of thrombin: stimulation of monocyte chemotactic protein production.
Authors: G Grandaliano, A J Valente, H E Abboud
Journal: The Journal of Experimental Medicine (1994)

Thrombin is a serine protease that is released at sites of vascular injury and exerts a variety of biologic effects on different cell types. Thrombin is postulated to play a role in the pathogenesis of a number of diseases including atherosclerosis, since it activates vascular smooth muscle and endothelial cells. Thrombin mediates these effects through a specific receptor that is upregulated in vascular cells in atherosclerosis. Atherosclerosis and glomerulosclerosis are characterized by the presence of monocyte-macrophages in the lesions. Monocyte chemotactic protein (MCP-1) is believed to be an important mediator of monocyte recruitment to the tissue and can be induced in a broad variety of cells including mesangial cells. We studied the effect of thrombin on MCP-1 production and gene expression in well-characterized human mesangial cells, vascular pericytes that play a central role in fibrosis of the glomerular microvascular bed. alpha thrombin stimulates MCP-1 production and gene expression in mesangial cells in a dose- and time-dependent manner. Experiments with diisopropylfluorophosphate thrombin and gamma thrombin demonstrate that this thrombin effect requires both receptor binding as well as catalytic activity, features consistent with the known properties of the recently characterized and cloned thrombin receptor. Moreover, a human thrombin receptor activating peptide (TRAP1-7) also stimulates MCP-1 production. Northern blot analysis demonstrated that mesangial cells express an mRNA transcript that hybridizes with labeled human thrombin receptor cDNA. These data describe a novel biologic activity of thrombin and suggest an additional mechanism by which this coagulation factor may participate in the progression of glomerulosclerosis, and by analogy, atherosclerosis.
Geriatric Service in Glasgow
Authors: T. H. Howell
Journal: BMJ (1972)

Attempts to keep up to date with advances in any branch of medicine become more and more difficult.Cardiologists can thus be grateful to Professors Yu and Goodwin for setting out to alleviate the major problems of communication and information retrieval.This book is the first of a series in which growing points in cardiology will be selected, reviewed, and assessed.There are ten chap- ters and contributors are drawn more or less equally from Britain and the U.S.A.The range of topics
Cell Membrane <i>Trans</i> -Fatty Acids and the Risk of Primary Cardiac Arrest
Authors: Rozenn N. Lemaitre, Irena B. King, Trivellore E. Raghunathan, Rachel M. Pearce, Sheila Weinmann, Robert H. Knopp, Michael K. Copass, Leonard A. Cobb, David S. Siscovick
Journal: Circulation (2002)

The relation of trans-fatty acid intake to life-threatening arrhythmias and primary cardiac arrest is unknown.We investigated the association of trans-fatty acid intake, assessed through a biomarker, with the risk of primary cardiac arrest in a population-based case-control study. Cases, aged 25 to 74 years, were out-of-hospital cardiac arrest patients attended by paramedics in Seattle, Washington from 1988 to 1999 (n=179). Controls, matched to cases by age and sex, were randomly identified from the community (n=285). Participants were free of previous clinically diagnosed heart disease. Blood was obtained at the time of cardiac arrest (cases) or at the time of an interview (controls) to assess trans-fatty acid intake. Higher total trans-fatty acids in red blood cell membranes was associated with a modest increase in the risk of primary cardiac arrest after adjustment for medical and lifestyle risk factors (odds ratio for interquintile range, 1.5; 95% CI, 1.0 to 2.1). However, trans isomers of oleic acid were not associated with risk (odds ratio for interquintile range, 0.8; 95% CI, 0.5 to 1.2), whereas higher levels of trans isomers of linoleic acid were associated with 3-fold increase in risk (odds ratio for interquintile range, 3.1; 95% CI, 1.7 to 5.4).These findings suggest that dietary intake of total trans-fatty acids is associated with modest increase and trans isomers of linoleic acid with a larger increase in the risk of primary cardiac arrest. These associations need to be confirmed in future studies that distinguish between trans isomers of linoleic acid and trans isomers of oleic acid.
Lipopolysaccharide-binding protein: a possible diagnostic marker for Gram-negative bacteremia in neutropenic cancer patients
Authors: Claudi S. M. Oude Nijhuis, Edo Vellenga, Simon M. G. J. Daenen, Winette T. A. van der Graaf, Jourik A. Gietema, Harry J. M. Groen, Willem A. Kamps, Eveline S. J. M. de Bont
Journal: Intensive Care Medicine (2003)
Choices of therapy for exercise-induced asthma in children
Authors: John F. Price
Journal: Allergy (2001)

Cough and wheezing interferes with sport and other forms of physical activity in half of asthmatic children. Airway obstruction can be induced by a standard exercise test in over 70% of children with asthma. A beta-adrenergic agonist or cromone taken by inhalation beforehand will usually inhibit bronchoconstriction provoked by a free running exercise test. The duration of protective effect with salbutamol, terbutaline and cromones is less than 4 h. The long acting beta-adrenergic agonists formoterol and salmeterol give protection against exercise-induced airway obstruction for up to 12 h, which implies that treatment given in the morning will offer protection from the effects of physical activity throughout the day. However, the duration of protective effect after a morning dose declines if these compounds are given regularly. Leukotriene receptor antagonists (LRAs) also provide good protection against exercise-induced asthma. Regular administration of LRAs is not associated with tolerance and loss of protective effect. The oral route makes for unobtrusive administration and this may help adherence to prescribed regimens.
Psychiatric Management for Medical Practitioners
Authors: Lawrence L. Hirsch
Journal: JAMA (1983)

According to present-day conventional wisdom, all specialties see a varying, though significant, number of patients with emotional problems as well as many patients who exhibit manifestations of overt psychiatric disease. Kornfeld and Finkel are concerned about experienced clinicians who feel a lack of time or deficient training prevents them from treating such patients. Blame for this unfortunate state is assigned to medical school programs that present psychiatric diagnosis but neither the basis of psychotherapy nor the niceties of psychopharmacology. Nevertheless, the authors posit that most physicians unknowingly apply some basic psychotherapeutic skills in everyday practice. Thus, this book is offered as "a supplement to standard textbooks of psychiatry," to enhance patient care, and to increase "physician satisfaction." Glancing at the table of contents produces a pleasant anticipation: 16 of 19 chapters promise "management" of commonly seen but important situations. Closer examination reveals the first three chapters are an extended introduction
Minocycline Compared with Doxycycline in the Treatment of Nongonococcal Urethritis and Mucopurulent Cervicitis
Authors: Barbara Romanowski
Journal: Annals of Internal Medicine (1993)

To compare the efficacy and tolerability of minocycline versus doxycycline in the treatment of nongonococcal urethritis and mucopurulent cervicitis.Randomized, double-blind trial.Sexually transmitted disease clinics.151 men and 102 women with nongonococcal urethritis, mucopurulent cervicitis or whose sexual partner had either condition or a positive culture for Chlamydia trachomatis.Minocycline, 100 mg nightly, or doxycycline, 100 mg twice daily, each administered for 7 days.At each visit (days 14 +/- 3, 28 +/- 5, and 49 +/- 7) patients were questioned regarding symptoms, signs, drug compliance, and sexual contact. Cultures for C. trachomatis, Ureaplasma urealyticum, and Mycoplasma hominis were obtained at each visit.253 patients were enrolled (133, doxycycline; 120, minocycline). Chlamydia trachomatis was initially isolated from 31% of men and 39% of women. Men with a positive smear had a higher symptom/sign score (P < 0.001) and were more likely to have chlamydia (P = 0.004). Positive endocervical smears were not associated with symptoms or signs (P > 0.2) but correlated with isolation of chlamydia (P < 0.001). One hundred sixty-two patients (64%) completed the study. The proportion with urethritis or cervicitis did not differ by treatment group at any follow-up visit (P > 0.08). Unprotected sexual contact did not affect clinical or microbiological cure rates. Adverse effects occurred more frequently in the doxycycline group (men: 43% versus 26%; P = 0.05; women: 62% versus 35%; P = 0.009). Although the proportion with dizziness did not differ by drug administered (P = 0.1), dizziness was reported more often by women (11% versus 3%).Minocycline, 100 mg nightly, was as effective as doxycycline, 100 mg twice daily, each given for 7 days in the treatment of nongonococcal urethritis and mucopurulent cervicitis. Vomiting and gastrointestinal upset occurred more frequently in the doxycycline group.
Visualization of Bone Structure With Tc-99m MIBI in a Patient on Hemodialysis
Authors: SEIGO KINUYA, SATOSHI ASAKA, RYOYU TAKEDA, KUNIHIKO YOKOYAMA, TAKATOSHI MICHIGISHI, NORIHISA TONAMI
Journal: Clinical Nuclear Medicine (1997)

A 51-year-old man on hemodialysis was studied with Tc-99m MIBI and I-123 scintigraphy for the assessment of a parathyroid mass. Although the results for the parathyroid detection were negative, bone structure was incidentally visualized with Tc-99m MIBI. Bone scintigraphy with Tc-99m MDP and marrow scintigraphy with In-111 chloride did not indicate a high bone turnover or marrow hyperplasia.