tbuckley/cabot-search huggingface dataset:
Implantation and intermediate-term follow-up of stents in congenital heart disease.
Authors: M P O'Laughlin, M C Slack, R G Grifka, S B Perry, J E Lock, C E Mullins
Journal: Circulation (1993)

Balloon-expandable stents (Johnson and Johnson Interventional Systems) have been in use for congenital heart disease since late 1989. They have made possible treatment in previously untreatable branch pulmonary artery stenoses and systemic venous stenosis. The purpose of this report is to detail the results and intermediate-term follow-up of stents used for treatment of congenital heart disease.Eighty-five patients underwent placement of 121 stents in Houston and Boston. Fifty-eight patients had stents put in pulmonary arteries, nine had stents in conduits or outflow tracts, and 21 had stents in venous stenoses or narrowed Fontan anastomoses. (Three patients had stents in two locations.) These stent procedures resulted in gradient reduction from 55.2 +/- 33.3 to 14.2 +/- 13.5 mm Hg in pulmonary arteries, from 41.4 +/- 26.0 to 20.7 +/- 17.0 mm Hg in conduits or outflow tracts, and from 9.8 +/- 6.9 to 2.4 +/- 3.1 mm Hg in venous stenoses or Fontan anastomoses. Diameter of narrowings increased from 4.6 +/- 2.3 to 11.3 +/- 3.2 mm in the pulmonary artery, from 8.8 +/- 3.6 to 12.7 +/- 2.6 in conduits, and from 3.8 +/- 2.9 to 11.3 +/- 2.8 in venous stenoses. Follow-up has shown stent fracture in one patient, restenosis in one, and sudden death in one. Recatheterization has been done in 38 patients an average of 8.6 months after stent installation. Compared with immediately postimplant data, there was no significant change in luminal diameter or pressure gradient. Redilation was performed in 14 patients (17 stents) 1 week to 24 months after implantation (mean, 10.2 months), with a small but significant increase in stenosis diameter.We conclude that stent treatment of vascular stenoses in congenital heart disease retains efficacy at medium-term follow-up and offers a much-improved outlook for patients with these lesions.
The Course of Untreated Recurrent Genital Herpes Simplex Infection in 27 Women
Authors: Mary E. Guinan, Janet MacCalman, Earl R. Kern, James C. Overall, Spotswood L. Spruance
Journal: New England Journal of Medicine (1981)

GENITAL herpes simplex infection affects an unknown but ever increasing number of persons in the United States. Because of the lack of a national surveillance system, no reliable data are available to determine either the magnitude or the growth rate of this problem. However, reports from three different parts of the country indicate that genital herpes is diagnosed more frequently than gonorrhea in women visiting private gynecologists.1 2 3 Women are particularly burdened with this infection: in addition to the morbidity associated with recurring episodes, they may incur an increased risk of cervical cancer, 4 and they may transmit a severe or fatal . . .
Selective versus routine predischarge coronary arteriography after therapy with recombinant tissue-type plasminogen activator, heparin and aspirin for acute myocardial infarction
Authors: William J. Rogers, Joseph D. Babb, Donald S. Baim, James H. Chesebro, Joel M. Gore, Robert Roberts, David O. Williams, Margaret Frederick, Eugene R. Passamani, Eugene Braunwald
Journal: Journal of the American College of Cardiology (1991)
Revision of the Code of Ethics.
Authors: Solomon Solis Cohen
Journal: JAMA (1893)

<h3>To the Editor of the Journal of the American Medical Association:</h3><h3>Dear Sir:</h3> —The "Code" question is admirably epitomized in two letters published inThe Journalof April 22. A correspondent writing from San José, Cal., with evident sincerity advances in effect the following argument: "The Code is daily violated by men apparently respectable;<i>therefore</i>, the Code should be repealed." In this benighted commonwealth of Pennsylvania, Mr. Editor, when, not long ago, men high in political station and prominent in the church were found to be guilty of forgery and embezzlement, we did not either strike out the eighth commandment from our copies of the decalogue, or repeal the criminal code of the State. We sent the highly respectable criminals to the penitentiary. While among those opposed to certain provisions of the Code or to any code, are many who are actuated by the highest motives, I fear that all
Short-contact dithranol therapy-modifications of the Ingram regime
Authors: B.N. Statham, K.S. Ryatt, N.R. Rowell
Journal: British Journal of Dermatology (1984)

Journal Article Short‐contact dithranol therapy‐modifications of the Ingram regime Get access B.N. Statham, B.N. Statham The General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar K.S. Ryatt, K.S. Ryatt The General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar N.R. Rowell N.R. Rowell The General Infirmary, Leeds Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue s26, 1 July 1984, Page 17, https://doi.org/10.1111/j.1365-2133.1984.tb05233.x Published: 01 July 1984
Investigation Into the Sources of Superoxide in Human Blood Vessels
Authors: Colin Berry, Carlene A. Hamilton, M. Julia Brosnan, Fergus G. Magill, Geoffrey A. Berg, John J. V. McMurray, Anna F. Dominiczak
Journal: Circulation (2000)

Increased vascular superoxide anion (.O(2)(-)) production contributes to endothelial dysfunction and hypertension in animal models of cardiovascular disease. Observations in experimental animals suggest that angiotensin II (Ang II) increases.O(2)(-) production by activation of vascular NAD(P)H oxidase. We studied the sources of.O(2)(-) production in human blood vessels and investigated whether, and by what mechanism, Ang II might alter vascular.O(2)(-) production.Internal mammary arteries (IMAs) and saphenous veins (SVs) were collected at the time of cardiac surgery. Vessels were incubated in Krebs buffer at 37 degrees C.O(2)(-) was measured by lucigenin chemiluminescence. Basal. O(2)(-) concentrations were greater in IMAs than SVs. Inhibitors of NAD(P)H oxidase (10 micromol/L to 200 micromol/L diphenyleneiodonium) and xanthine oxidase (1 mmol/L allopurinol) caused reductions in.O(2)(-) concentrations in both IMAs and SVs. Western blotting of superoxide dismutase proteins demonstrated similar expression in IMAs and SVs. Vessels were also incubated in the presence or absence of Ang II (1 pmol/L to 1 micromol/L). Ang II increased.O(2)(-) production in IMAs at 4 hours of incubation (control, 978+/-117 pmol. min(-1). mg(-1); 1 micromol/L of Ang II, 1690+/-213 pmol. min(-1). mg(-1); n=27, P=0.0001, 95% CI 336, 925) but not in SVs. This effect was completely inhibited by coincubation of IMAs with DPI (100 micromol/L), a nonspecific Ang II antagonist ([sar(1), thre(8)]-Ang II, 1 micromol/L) and a specific Ang II type 1 (AT(1)) receptor antagonist (losartan, 1 micromol/L). Conclusions-. O(2)(-) production is greater in human IMAs than in SVs. NAD(P)H oxidase and xanthine oxidase are sources of.O(2)(-) production in these vessels. The vasoactive peptide Ang II increases.O(2)(-) production in human arteries by an AT(1) receptor-dependent mechanism.
Hemolytic Effect of Sulfonamides in Patients with Erythrocytes Deficient in Glucose-6-Phosphate Dehydrogenase
Authors: Carl W. Norden, Jane F. Desforges, Edward H. Kass
Journal: New England Journal of Medicine (1968)

TREATMENT of infection often necessitates the use of drugs that can cause hemolytic reactions in patients with erythrocytes deficient in glucose-6-phosphate dehydrogenase (G-6-PD). Nitrofurantoin a...
Endoscopic ultrasound in the investigation of unexplained thickening of esophagogastric wall
Authors: S. Rana, D. Bhasin, K. Singh
Journal: Endoscopy (2009)

We read with interest the study by Thomas et al. [1] that highlighted the role of endoscopic ultrasound (EUS)-guided mural trucut biopsies (TCB) in patients with esophagogastric wall thickening and negative endoscopy and mucosal biopsies. The patients with thickened esophageal wall on computed tomography (CT) and normal mucosa on endoscopy as well as negative endoscopic biopsy pose a difficult diagnostic challenge. These patients usually undergo repeated endoscopic biopsies or fine-needle aspiration (FNA) under endoscopic guidance, with poor diagnostic yield. EUS-guided FNA has improved immensely our diagnostic capability but the sensitivity of this technique is low for focal mural lesions [2] [3]. The study by Thomas et al. [1] has shown that EUS-TCB is a safe technique with a high sensitivity for evaluating patients with unexplained esophagogastric wall thickening, and thus will help in solving clinical dilemmas like the one we encountered in one of our patients.
Hospitals still don't do enough for patients' privacy and dignity
Authors: Stephen Pincock
Journal: BMJ (2004)

Care in hospitals in England and Wales has improved significantly over the past four years, but the quality of service received by patients still depends too much on where they live, the Commission for Health Improvement (CHI) has said in a report.

The report says that hospital care is now more focused on the needs of patients and that progress has been made in reducing waiting times in emergency departments and for outpatient appointments.

“Significant improvements have been made in hospital trusts in the four years since CHI began reviewing the services they provide,” the commission's acting chief executive, Jocelyn Cornwell, said in a statement. …
Coblentz Not With Medical Research Corporation
Authors: V. Coblentz
Journal: JAMA (1910)

<h3>To the Editor:—</h3> In one of the summer numbers ofThe Journal(Aug. 6, 1910, p. 519), there appeared an article relative to the "Medical Research Corporation" ["International Encyclopedia of Ethical Non-Official Pharmaceuticals"] with which I was at that time connected as editor-in-chief. I call attention to the fact that I have severed my connection with this corporation.
Paracelsus: Medicine, Magic and Mission at the End of Time
Authors: Christopher Hamlin
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of a Reduction in Environmental Temperature on the Circulatory Response to Exercise in Man
Authors: Stephen E. Epstein, Morris Stampfer, G. David Beiser, Robert E. Goldstein, Eugene Braunwald
Journal: New England Journal of Medicine (1969)

The physiologic basis for the frequent complaint of worsening of symptoms in a cold environment was investigated in six patients with and five without coronary-artery disease, at rest and during identical levels of mild upright exercise at 25 and 15°C, with similar results. Significantly higher at the lower temperature were mean systemic arterial pressure (105 vs 92 mm of mercury at rest and 110 vs 92 during exercise; p less than 0.001), total peripheral resistance (1821 vs 1609 dynes-sec-cm-5 at rest, 1213 vs 993 during exercise; p less than 0.02) and left ventricular minute work (6.5 vs 5.7 kg-m at rest, 10.9 vs 9.0 during exercise; p less than 0.001). Exposure to cold did not change heart rate, cardiac output or stroke volume at rest or during exercise. These results indicate that a cold environment increases peripheral resistance at rest and during exercise. The consequent rise in arterial pressure, by augmenting myocardial oxygen requirements, would thus more readily provoke an attack of angina.
Acute Maxillary Sinusitis in Children
Authors: Ellen R. Wald, Gregory J. Milmoe, A'Delbert Bowen, Jocyline Ledesma-Medina, Nan Salamon, Charles D. Bluestone
Journal: New England Journal of Medicine (1981)

We sought to correlate the clinical, radiographic, and bacteriologic findings in maxillary sinusitis in 30 children who had both upper-respiratory-tract symptoms and abnormal maxillary radiographs. Cough, nasal discharge, and fetid breath were the most common signs, but fever was present inconsistently. Facial pain or swelling and headache were prominent symptoms in older children. Bacterial colony counts of greater than or equal to 10(4) colony-forming units per milliliter were found in 34 of 47 sinus aspirates obtained from 23 children. The most common species recovered were Streptococcus pneumoniae, Haemophilus influenzae, and Branhamella catarrhalis. No anaerobic bacteria were isolated. Viruses were isolated from only two sinus aspirates. There was a poor correlation between the predominant species of bacteria recovered from either the nasopharyngeal or throat culture and the bacteria isolated from the sinus aspirate. This study demonstrates that children with both upper-respiratory-tract symptoms and abnormal sinus radiographs are likely to harbor bacteria in their sinuses, suggesting that such children have bacterial sinusitis.
Fibronectin-mediated Calmette-Guerin bacillus attachment to murine bladder mucosa. Requirement for the expression of an antitumor response.
Authors: L R Kavoussi, E J Brown, J K Ritchey, T L Ratliff
Journal: Journal of Clinical Investigation (1990)

Adjuvant intravesical Calmette-Guerin bacillus (BCG) is an effective treatment for superficial bladder cancer. The mechanisms by which BCG mediates antitumor activity are not known. We investigated the initial interaction of BCG with the bladder mucosa to determine whether binding was essential for the development of antitumor activity. Herein, we show that bladder urothelial disruption induced by acrolein, adriamycin, or electrocautery resulted in BCG binding in areas of urothelial damage. Binding induced by each method was inhibited by anti-fibronectin (FN) antibodies but not by antibodies to the basement membrane component laminin. Intravesical BCG binding also was inhibited by pretreating BCG with soluble FN. Inhibition of intravesical FN-mediated BCG attachment prevented immunization via the intravesical route. Moreover, the expression of both delayed hypersensitivity in the bladder of BCG-immunized mice and antitumor activity was inhibited by blocking FN-mediated intravesical BCG attachment. These data suggest that intralumenal attachment of BCG appears to be mediated by FN. Moreover, these data suggest that intravesical FN mediated attachment of BCG is a requisite step in BCG-mediated antitumor activity in the murine bladder tumor model.
Plasma Renin Concentration in Human Hypertension--III: Renin in Relation to Complications of Hypertension
Authors: J. J. Brown, D. L. Davies, A. F. Lever, J. I. S. Robertson
Journal: BMJ (1966)

I. Malignant Phase of HypertensionThe term "malignant hypertension" has been used in slightly different senses by previous writers, but generally implies severe elevation of the blood-pressure with very limited prognosis if untreated.Ophthalmoscopically, the malignant phase is characterized by retinal haemorrhages, exudates, and papilloedema.Histologically the essential lesion is fibrinoid arteriolar necrosis, especially of the afferent glomerular arterioles. (a) Relationship between Retinopathy and Renal HistologyRenal histology was studied in 104 patients, in nearly all instances on biopsy material.Fibrinoid arteriolar necroses were found in 11 out of 16 cases with bilateral retinal haemorrhages, on 14 July
Enhancement of Portal Pressure Reduction by the Association of Isosorbide–5–Mononitrate to Propranolol Administration in Patients With Cirrhosis
Authors: Joan Carles Garcia-Pagan, Miquel Navasa, Jaime Bosch, Conxita Bru, Pilar Pizcueta, Joan Rodes
Journal: Hepatology (1990)

This study investigated whether oral doses of isosorbide-5-mononitrate, a preferential venous dilator that decreases portal pressure, could enhance the effects of propranolol on portal hypertension. Taking part in the study were 28 patients with cirrhosis and portal hypertension. Twenty patients (group 1) had hemodynamic measurements in baseline conditions after beta-blockade by intravenous administration of propranolol and after receiving oral doses of isosorbide-5-mononitrate. The remaining eight patients (group 2) were given oral isosorbide-5-mononitrate while receiving chronic propranolol therapy. In group 1, propranolol significantly reduced portal pressure (estimated as the gradient between wedged and free hepatic venous pressures) from 21.5 +/- 3.9 to 18.6 +/- 4.2 mm Hg (-13.7%, p less than 0.001), azygos blood flow (-38%, p less than 0.001), hepatic blood flow (-12.8%, p less than 0.05), cardiac output (-24.5%, p less than 0.001) and heart rate (-18.4%, p less than 0.001) without significant changes in mean arterial pressure. Addition of oral isosorbide-5-mononitrate caused a further and marked fall in portal pressure (to 15.7 +/- 3.1 mm Hg, p less than 0.001), without additional changes in azygos blood flow but with significant additional reductions in hepatic blood flow (-15.5%, p less than 0.05), cardiac output (-11.5%, p less than 0.001) and mean arterial pressure (-22%, p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
Is Brain Natriuretic Peptide Production Decreased in Obese Subjects?
Authors: Roland van Kimmenade, François van Dielen, Jaap Bakker, Jeroen Nijhuis, Harry Crijns, Wim Buurman, Marja van Dieijen-Visser, Jan-Willem Greve, Yigal Pinto
Journal: Journal of the American College of Cardiology (2006)
Incapacity benefit reform and the politics of ill health
Authors: C. I Bambra
Journal: BMJ (2008)

In October 2008 incapacity benefit in the United Kingdom will be replaced, for new but not existing claimants, by the employment support allowance.1 This radical change has been largely ignored by health professionals, despite the role of general practitioners in the diagnosis and certification of long term sickness absence,2 the involvement of the NHS (usually via primary care) in interventions for getting incapacity benefit claimants back to work (notably the condition management programme and Pathways to Work),2 and the importance of income maintenance policies for the health of individuals and the population.3 But the reform of incapacity benefit signifies a dangerous political shift in how chronically ill and disabled patients are seen as either “deserving” or “undeserving” of state support.4 Such a shift will have important implications for the health professionals involved.

Incapacity benefit, the main social security cash benefit that isn’t means tested, is paid to 2.7 million people in the UK. Recipients, who need to have contributed sufficient national insurance payments, are assessed …
Remarks ON CHRONIC SPLENOMEGALIC POLYCYTHAEMIA
Authors: R. Saundby
Journal: BMJ (1907)

% Not increased -He was sent out on March 20th, but readmitted on March 24th, and when he was seen he was found to be deeply ejanosed and jaundiced, drowsy, apathetic, and passing his uriin in the bed.The fingers, ears cheeks, nose, and -skiu of his back are described as being of a.purplish colour; temperatureW.In spite of'the jisundice, the urine contained no bble an4 aord- iug to Dr. PXt1w*s'Wlits, -now o )Ianchesten, tkenasident
Tracking down Human Contamination in Ancient Human Teeth
Authors: María Lourdes Sampietro, M. Thomas P. Gilbert, Oscar Lao, David Caramelli, Martina Lari, Jaume Bertranpetit, Carles Lalueza-Fox
Journal: Molecular Biology and Evolution (2006)

DNA contamination arising from the manipulation of ancient calcified tissue samples is a poorly understood, yet fundamental, problem that affects the reliability of ancient DNA (aDNA) studies. We have typed the mitochondrial DNA hypervariable region I of the only 6 people involved in the excavation, washing, and subsequent anthropological and genetic study of 23 Neolithic remains excavated from Granollers (Barcelona, Spain) and searched for their presence among the 572 clones generated during the aDNA analyses of teeth from these samples. Of the cloned sequences, 17.13% could be unambiguously identified as contaminants, with those derived from the people involved in the retrieval and washing of the remains present in higher frequencies than those of the anthropologist and genetic researchers. This finding confirms, for the first time, previous hypotheses that teeth samples are most susceptible to contamination at their initial excavation. More worrying, the cloned contaminant sequences exhibit substitutions that can be attributed to DNA damage after the contamination event, and we demonstrate that the level of such damage increases with time: contaminants that are >10 years old have approximately 5 times more damage than those that are recent. Furthermore, we demonstrate that in this data set, the damage rate of the old contaminant sequences is indistinguishable from that of the endogenous DNA sequences. As such, the commonly used argument that miscoding lesions observed among cloned aDNA sequences can be used to support data authenticity is misleading in scenarios where the presence of old contaminant sequences is possible. We argue therefore that the typing of those involved in the manipulation of the ancient human specimens is critical in order to ensure that generated results are accurate.
Pyretotherapy and Subcutaneous Hexamethonium in the Treatment of Severe and Malignant Hypertension
Authors: PABLO THOMSEN, RAMÓN ORTÚZAR, FERNANDO GOÑI, CRISTOBAL ESPÍLDORA-LUQUE, LEÓN VIAL
Journal: Circulation (1956)

The permanent lowering of arterial pressure in cases of malignant and severe hypertension is of paramount importance. A new treatment that combines subcutaneous administration of hexamethonium with fever therapy produced by intravenous injections of bacterial vaccine is described. Reduction of blood pressure to normal levels and improvement of eye grounds, electrocardiogram, heart condition and subjective symptoms were obtained. The basis for these effects could be the potentiation of the action of hexamethonium produced by the induced fever.