tbuckley/cabot-search huggingface dataset:
von Hippel-Lindau Tumor Suppressor Protein Regulates the Assembly of Intercellular Junctions in Renal Cancer Cells through Hypoxia-Inducible Factor–Independent Mechanisms
Authors: Maria J. Calzada, Miguel A. Esteban, Monica Feijoo-Cuaresma, Maria C. Castellanos, Salvador Naranjo-Suárez, Elisa Temes, Fernando Méndez, Maria Yánez-Mo, Michael Ohh, Manuel O. Landázuri
Journal: Cancer Research (2006)

Abstract Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene is responsible for the development of renal cell cancers (RCC), pheochromocytomas, and tumors in other organs. The best known function of VHL protein (VHL) is to target the hypoxia-inducible factor (HIF) for proteasome degradation. VHL is also required for the establishment of an epithelial-like cell shape in otherwise fibroblastic-like RCC cell lines. However, the underlying mechanisms and whether this is linked to HIF remain undetermined. Because the breakage of intercellular junctions induces a fibroblastic-like phenotype in multiple cancer cell models, we hypothesized that VHL may be required for the assembly of intercellular junctions in RCC cells. Our experiments showed that VHL in RCC cell lines is necessary for the normal organization of adherens and tight intercellular junctions, the maintenance of cell polarity, and control of paracellular permeability. Additionally, 786-O cells reconstituted with wild-type VHL and with a constitutively active form of HIF-2α did not reproduce any of the phenotypic alterations of VHL-negative cells. In summary, we show that VHL inactivation in RCC cells disrupts intercellular junctions and cell shape through HIF-independent events, supporting the concept that VHL has additional functions beside its role in the regulation of HIF. (Cancer Res 2006; 66(3): 1553-60)
Internalization and cell cycle-dependent killing of leukemic cells by Gemtuzumab Ozogamicin: rationale for efficacy in CD33-negative malignancies with endocytic capacity
Authors: I Jedema, R M Y Barge, V H J van der Velden, B A Nijmeijer, J J M van Dongen, R Willemze, J H F Falkenburg
Journal: Leukemia (2003)
Douglas-Stromme Operative Obstetrics
Authors: Warren C. Plauché
Journal: JAMA (1982)

The general format of this book is well conceived and elegantly resolved. I encountered only a few misspelled words in the text. Specific comments follow. The forceps section is the outstanding example of this subject that I have encountered. Inclusion of the Task Force report on electronic fetal monitoring is innovative, but one wonders about its place in a surgical text. The section on cesarean hysterectomy contained several problems: the recommendation on page 637 that the baby is best delivered by breech extraction after podalic version if need be; absence of directions to the reader-surgeon to clamp paracervical and uterosacral tissues before their dissection from the uterus; the purse string reperitonealization of the pelvis, which, as the illustration clearly shows, brings the ovaries to a position right down on the vaginal cuff. The discussion, photographs, and illustrations of episiotomy and repair are outstanding. The Broedel illustrations of breech delivery, seemingly
TCT-621 Drug-Eluting Stent Event Registry of Thrombosis (DESERT): The International Drug-Eluting Stent Thrombosis Registry, Angiographic Assessment
Authors: Ron Waksman, Rebecca Torguson, Kimberly Kaneshige, Ajay Kirtane, Thomas Ryan, Lorenz Räber, Robert Applegate, Sergio Waxman, David Cohen, Paul Gordon
Journal: Journal of the American College of Cardiology (2012)
Mother-Daughter Interaction and Adherence to Diabetes Regimens
Authors: Elisa S Bobrow, Theodore W AvRuskin, Jerome Siller
Journal: Diabetes Care (1985)

This study explores the relationship of mother-daughter interaction to adherence to treatment plans among diabetic adolescents. Fifty mother-daughter dyads discussed conflict issues and feelings, problems, and concerns related to diabetes. Discussions were analyzed using the Hill Interaction Matrix and modified Beavers-Timberlawn Family Evaluation Scales. Interview questionnaires provided information on adherence, feelings, problems and concerns, parental supervision, adjustment, and family life. The less adherent the adolescent, the more emotionally charged the interaction, the more directly confrontive mother and daughter were, and the less efficient they were at negotiating issues. The adolescent's statements about herself confirmed observations that poor adherers, more than good adherers, had difficulty discussing feelings, problems, and concerns with their mothers (r = −0.51, P ≤ 0.001). Poor adherers reported believing less strongly that adherence would delay/avoid complications (r = 0.51, P ≤ 0.001), became more anxious about seeing a disabled diabetic person (r = −0.29, P ≤ 0.29), and worried more about future health (r = −0.27, P = NS). No relationships were found between adherence and adolescent-physician rapport. Many adolescents were not engaging in good self-care behaviors, were quite concerned about future health, perceived mothers to be very concerned, hesitated telling peers about their illness, and did not share deeper illness-related concerns with their closest nondiabetic friends.
Trial of combination of guanethidine and oxprenolol in hypertension.
Authors: R M Pearson, M R Bending, C J Bulpitt, C F George, D R Hole, F M Williams, A M Breckenridge
Journal: BMJ (1976)

Thirteen hypertensive patients entered a double-blind crossover trial of guanethidine and oxprenolol in combination. In nine patients who completed the trial there was an additive effect on blood pressure, but the combination had a smaller effect on heart rate than was expected from the individual effects, and side effects were not increased. During treatment with oxprenolol the plasma potassium concentration rose from 3.6 mmol (mEq)/1 to 3.9 mmol (mEq)/1. No correlation was found between the plasma oxprenolol concentration and changes in blood pressure or response to injected isoprenaline, but measurements of plasma oxprenolol concentrations were of value in determining compliance with the protocol.
Infective endocarditis in patients with an implanted transcatheter aortic valve: Clinical characteristics and outcome of a new entity
Authors: Juan M Pericas, Jaume Llopis, Carlos Cervera, Emilio Sacanella, Carlos Falces, Rut Andrea, Cristina Garcia de la Maria, Salvador Ninot, Bàrbara Vidal, Manel Almela, Juan C Paré, Manel Sabaté, Asunción Moreno, Francesc Marco, Carlos A Mestres, Jose M Miro
Journal: Journal of Infection (2015)
Proinsulin Secretion During the First 3 Years After Diagnosis in Diabetic Patients With and Without Islet Cell Antibodies
Authors: A Gottsäter, D R Owens, S Luzio, G Sundkvist
Journal: Diabetes Care (1996)

OBJECTIVE To evaluate proinsulin secretion in different types of NIDDM. RESEARCH DESIGN AND METHODS Proinsulin and insulin were evaluated at diagnosis of diabetes and 3 years later (fasting and after stimulation with intravenous glucose and glucagon) in 10 NIDDM patients without islet cell antibodies (ICAs) at diagnosis (age 52 ± 4 years), 11 NIDDM patients with ICAs at diagnosis (age 50 ± 5 years), and 21 healthy control subjects (age 53 ± 4 years). RESULTS At diagnosis, fasting proinsulin was higher in NIDDM patients without ICAs than in control subjects (39.6 ± 10.0 vs. 12.8 ± 1.6 pmol/l, P &amp;lt; 0.01). Proinsulin response to intravenous glucose decreased in NIDDM patients with ICAs (from 35.6 ± 6.2 to 13.5 ± 5.4 pmol/l, P &amp;lt; 0.05), but remained unchanged in those without ICAs. At 3 years after diagnosis, fasting proinsulin (10.0 ± 3.7 vs. 59.1 ± 17.0 pmol/l) and proinsulin responses to intravenous glucose (13.5 ± 5.4 vs. 103.9 ± 35.1 pmol/l) and to intravenous glucagon (7.4 ± 3.9 vs. 36.0 ± 7.7 pmol/l) were much lower (P &amp;lt; 0.01) in NIDDM patients with ICAs than in those without ICAs. CONCLUSIONS After diagnosis of diabetes, proinsulin secretion decreases significantly in NIDDM patients with ICAs and remains constant in those without.
Use of Trimeprazine to Control Pruritus in Orthopedic Surgery
Authors: Ben T. Bell
Journal: JAMA (1960)

IT IS OBVIOUS that the orthopedic surgeon often creates conditions that can result in pruritus—the noxious stimulation of cutaneous sensory receptors or, more rarely, the hyperirritability of peripheral receptor end organs. The most common causes for pruritus in orthopedics are physical stimuli such as heat, pressure, friction, and tickling dressings. The next most frequent causes are chemical stimuli prduced by drainage or by an allergic reaction to a locally applied substance or drug, such as tape or mercurial antiseptic. Finally, hyperirritability of the cutaneous nerve endings accompanying senile skin changes (or induced occasionally by back braces which press on the lateral femoral cutaneous nerve) may give rise to troublesome paresthesias, predominantly itching. This mechanism of increased irritability may also be a factor in the persistent itch that accompanies healing incisions and incisional scars. Schoch and colleagues<sup>1</sup>recently listed four corrective measures that would be useful in controlling pruritus. Briefly,
Left Ventricular Hypertrophy by Electrocardiogram
Authors: WILLIAM B. KANNEL
Journal: Annals of Internal Medicine (1969)

In a general population sample of 5,209 in Framingham, Mass., the prevalence of left ventricular hypertrophy by electrocardiogram was commoner in men than in women, and it rose with age. In 12 years 3.0% developed a definite and 4.5% developed a possible pattern. Incidence was strongly related to blood pressure, but less than half of those with the pattern had definite heart enlargement on X ray. Some 55% of the cases of congestive heart failure and 27% of the coronary heart disease cases were either preceded or followed by the pattern. Prognosis was very grave. A definite pattern even when unassociated with coronary heart disease, congestive heart failure, or rheumatic heart disease resulted in mortality of 59% within 12 years. One in 2 men over 45 years old died within 8 years of developing a definite pattern. Altogether, 44% of the 264 cardiovascular deaths were preceded by a definite or possible finding of left ventricular hypertrophy by electrocardiogram.
An "unavoidable" death in a people's marathon.
Authors: M. A. Parsons, P. B. Anderson, B. T. Williams
Journal: British Journal of Sports Medicine (1984)

With the increase in jogging and distance running as a means of attaining and maintaining fitness, and in the light of the difficulty in advising certain groups of patients about their capacity for such exercise, we report on several potentially avoidable factors in the death of a 45 year old Sheffield Marathon runner in June 1983.
Patterns of Blood Pressure in Milwaukee
Authors: Harold D. Itskovitz
Journal: JAMA (1977)

Blood pressure measurements were obtained among 92,074 persons in Milwaukee between 1974 and 1976 by the Milwaukee Blood Pressure Program. Systolic hypertension was more prevalent in young white men than blacks below 25 years of age, was more common in middle-aged blacks than whites, and was equally prevalent among all persons past 65 years. Diastolic hypertension was more prevalent in blacks than whites of all ages. Whereas the prevalence of systolic hypertension in the population increased with age and was present in a majority or near majority of persons past 65 years, the prevalence of diastolic hypertension rose until the sixth decade, after which it declined. Hypertension was primarily of a diastolic variety in young blacks, whereas systolic hypertension was a prominent feature in young whites.
Fully automated computer analysis of intracolonic pressures.
Authors: J Rogers, J J Misiewicz
Journal: Gut (1989)

A fully automated (PC compatible) software and hardware analysis system has been designed and developed to analyse colonic pressure records quickly and objectively. Eight hours of colonic pressure trace was analysed in 48 10 minute epochs manually and by computer for the variables of mean amplitude, % duration of activity, motility index, number of peaks and activity index. Agreement between methods was good for mean amplitude: (bias -0.5 mmHg; (36.8) (2 SD, limits of agreement); -5.8 to 4.8, 95% CI of bias; 0-289, average range of values by both methods), % duration of activity: (-0.9; (13.4); -2.9 to 0.9; 0-100), motility index: (-55; (2072); -356 to 245; 0-26,220), number of peaks: (-20; (91); -44 to 3.5; 1-211), and activity index bias -5.2 mmHg. min; (127.3); -23.7, to 13.2; 0-2159. The time taken for manual analysis was 889 minutes compared with 14 minutes for the automated system. Fully automated analysis of colonic pressure records is fast, objective, and shows good agreement with labour intensive manual analysis. Previously acquired data can be reanalysed using new definitions and criteria. Widespread use of the technique could introduce uniformity in colonic pressure record analysis. In addition this wave form analysis system can be adapted to record and analyse pressure data from other regions of the gastrointestinal tract.
How to write perfect medical articles every time
Authors: T. Greenhalgh
Journal: BMJ (1995)

There is a man who advertises regularly in the Sunday papers for people wishing to earn large sums of money writing articles for magazines. Several groups of aspiring medical journalists have chosen to give me a free meal rather than buy his book, and, as a columnist for several magazines, I have faced packed audiences eager to glean the secrets of my purportedly lucrative trade. My listeners are, of course, self selecting, but to a man and woman they claim to be sitting on reams of unpublished articles, and, more often than not, on mounting piles of rejection slips.

The BMJ's recent competition to find …
The risks and benefits of long‐term use of hydroxyurea in sickle cell anemia: A 17.5 year follow‐up
Authors: Martin H. Steinberg, William F. McCarthy, Oswaldo Castro, Samir K. Ballas, F. Danny Armstrong, Wally Smith, Kenneth Ataga, Paul Swerdlow, Abdullah Kutlar, Laura DeCastro, Myron A. Waclawiw, E. Orringer, S. Jones, D. Strayhorn, W. Rosse, G. Phillips, D. Peace, A. Johnson-Telfair, Lisa H Daitch, P. Milner, A. Tracy, S. Valdez, G. E. Allen, J. Moshang, B. Scott, C. Bigelow, A. Anderson, V. Sabahi, T. Harrington, W. Labrousse, C. Pegelow, D. Temple, E. Case, R. Harrell, S. Childerie, S. Embury, B. Schmidt, D. Davies, Y. Saunthararajah, M. Koshy, N. Talischy-Zahed, L. Dorn, G. Pendarvis, M. McGee, M. Telfer, A. Davis, O. C. Onyekwere, C. Nwokolo, H. Finke, E. Perlin, J. Siteman, M. Bryan, T. Saunders, Y. Barber, P. Gascon, P. Di Paolo, S. Gargiulo, J. Eckman, E. Carter-Randall, J. H. Bailey, A. Platt, L. Waller, G. Ramirez, V. Knors, S. Hernandez, E. M. Rodriguez, E. Wilkes, E. Vichinsky, W. Hagar, C. Hoehner, E. Hackney-Stevens, S. Claster, A. Earles, K. Kleman, K. McLaughlin, L. White, B. Maddox, L. Usry, A. Brenner, K. Williams, R. O'Brien, K. Genther, S. Shurin, B. Berman, K. Chiarucci, L. Keverline, N. Olivieri, J. Chow, M. Hui, D. Shaw, N. Lewis, M. Okam, E. Mandell, A. Palmer, K. Bridges, B. Tynan, C. Winograd, R. Bellevue, H. Dosik, M. Sheikhai, P. Ryans, H. Souffrant, B. Adler, L. Eskridge, J. Prchal, J. Braddock, T. McArdle, T. Carlos, A. Roundtree-Schmotzer, D. Gardner
Journal: American Journal of Hematology (2010)

A randomized, controlled clinical trial established the efficacy and safety of short-term use of hydroxyurea in adult sickle cell anemia. To examine the risks and benefits of long-term hydroxyurea usage, patients in this trial were followed for 17.5 years during which they could start or stop hydroxyurea. The purpose of this follow-up was to search for adverse outcomes and estimate mortality. For each outcome and for mortality, exact 95% confidence intervals were calculated, or tests were conducted at alpha = 0.05 level (P-value <0.05 for statistical significance). Although the death rate in the overall study cohort was high (43.1%; 4.4 per 100 person-years), mortality was reduced in individuals with long-term exposure to hydroxyurea. Survival curves demonstrated a significant reduction in deaths with long-term exposure. Twenty-four percent of deaths were due to pulmonary complications; 87.1% occurred in patients who never took hydroxyurea or took it for <5 years. Stroke, organ dysfunction, infection, and malignancy were similar in all groups. Our results, while no longer the product of a randomized study because of the ethical concerns of withholding an efficacious treatment, suggest that long-term use of hydroxyurea is safe and might decrease mortality.
Enhanced Plasma Levels of Oxidized Low-Density Lipoprotein Increase Circulating Nuclear Factor-Kappa B Activation in Patients With Unstable Angina
Authors: Luciano Cominacini, Maurizio Anselmi, Ulisse Garbin, Anna Fratta Pasini, Chiara Stranieri, Massimiliano Fusaro, Cristina Nava, Pierfrancesco Agostoni, Dritan Keta, Pietro Zardini, Tatsuya Sawamura, Vincenzo Lo Cascio
Journal: Journal of the American College of Cardiology (2005)
Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease
Authors: Stefanie Sarantopoulos, Kristen E. Stevenson, Haesook T. Kim, Corey S. Cutler, Nazmim S. Bhuiya, Michael Schowalter, Vincent T. Ho, Edwin P. Alyea, John Koreth, Bruce R. Blazar, Robert J. Soiffer, Joseph H. Antin, Jerome Ritz
Journal: Blood (2009)
Kaplan and colleagues' reply
Authors: G. A Kaplan, J. W Lynch, R. D Cohen, J. L Balfour, E. R Pamuk
Journal: BMJ (1996)

EDITOR,—Ken Judge claims that our study about the relations between income inequality and mortality in the United States is methodologically flawed and cannot contribute much to the debate on income inequality and health. We agree that an understanding of the impact of taxes, benefits, and household composition on this relation is important. However, Judge's criticisms are factually in error (our income measure did include government cash benefits) and illogical. He is incorrect in stating that an overestimate of the extent of income inequality necessarily calls into question the association between inequality and mortality. This would be true only if adjustment for taxes, benefits, and …
UV-B exposure impairs resistance to infection by Trichinella spiralis.
Authors: W Goettsch, J Garssen, A Deijns, F R de Gruijl, H van Loveren
Journal: Environmental Health Perspectives (1994)

To assess the possibility that increases in UV-B exposure on the earth's surface could lead to impaired resistance to several infectious diseases, we studied the effect of UV-B exposure on resistance against Trichinella spiralis. Wistar rats, orally infected with T. spiralis larvae, were exposed to suberythemal doses of UV-B radiation daily for 5 days at different time periods before or after infection. A significant increase in the number of Trichinella larvae was found in the carcasses of rats irradiated with UV-B between 6 and 10 days after infection. These data indicate that exposure to UV-B radiation suppresses the resistance to a parasitic infection. We suggested that UV-B radiation especially suppresses cellular immune responses against these worms because specific IgM, IgG, and IgE titers were not significantly altered by UV-B exposure. These data indicate that UV-B irradiation plays a role in the course of infection with T. spiralis, which suggests that increases of UV-B exposure might also lead to problems with other infectious diseases and might affect vaccination because of the interaction of UV-B irradiation with memory T-cells.
Kenneth Herbert Walker
Authors: Michael Walter
Journal: BMJ (2006)

Former general practitioner Windsor, Berkshire (b 1908; q Guy's Hospital, London, 1939), died from congestive cardiac failure on 12 February 2006.

After war service with the Royal Army Medical Corps, mainly in India (1942-5), Kenneth entered general practice in Windsor in 1946, where he spent the rest of his career until his retirement in 1978. He was involved in St John Ambulance and was a lifelong Rotarian. Kenneth loved music, reading, and natural history. He continued to play bridge and take a keen interest in current affairs. He leaves a wife, Mary; three children; and five grandchildren.
Oral 13, An unexplained disorder of keratinization
Authors: M. Kalavala, R.G. Goodwin
Journal: British Journal of Dermatology (2007)

Journal Article Oral 13, An unexplained disorder of keratinization Get access M. Kalavala, M. Kalavala Department of Dermatology, Royal Gwent Hospital, Newport, U.K. Search for other works by this author on: Oxford Academic Google Scholar R.G. Goodwin R.G. Goodwin Department of Dermatology, Royal Gwent Hospital, Newport, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue 6, 1 June 2007, Page 1407, https://doi.org/10.1111/j.1365-2133.2007.07876_13.x Published: 01 June 2007
The HLA-DRB1 locus as a genetic component in giant cell arteritis. Mapping of a disease-linked sequence motif to the antigen binding site of the HLA-DR molecule.
Authors: C M Weyand, K C Hicok, G G Hunder, J J Goronzy
Journal: Journal of Clinical Investigation (1992)

Giant cell arteritis (GCA) is a granulomatous vasculitis affecting persons over 50 years of age. The inflammatory infiltrate, which is targeted at the aorta and its proximal branches, includes activated CD4+ helper T cells, histiocytes, and giant cells. To investigate whether the genetic polymorphism of the HLA-DRB1 genes contributes to the local accumulation of activated T cells, we have analyzed both HLA-DRB1 alleles in a cohort of 42 patients with biopsy-proven GCA. The majority of patients (60%) expressed the B1*0401 or B1*0404/8 variant of the HLA-DR4 haplotype, both of which also represent the major genetic factors underlying the disease association in RA. GCA patients negative for the disease-linked HLA-DR4 alleles were characterized by a nonrandom distribution of HLA-DRB1 alleles. Sequence comparison among the allelic products identified in the GCA cohort demonstrated heterogeneity for the sequence polymorphism of the third hypervariable region (HVR), but homology for the polymorphic residues within the HVR2 of the HLA-DRB1 gene. The GCA patients shared a sequence motif spanning amino acid positions 28-31 of the HLA-DR beta 1 chain. In the structural model for HLA-DR molecules, this sequence motif can be mapped to the antigen-binding site of the HLA complex, suggesting a crucial role of antigen selection and presentation in GCA. In contrast, the sequence polymorphism linked to RA has been mapped to the HVR3 of the HLA-DRB1 gene and translates into a distinct domain of the HLA-DR molecule, the alpha-helical loop surrounding the antigen-binding groove. A consecutive case series study demonstrated that GCA and RA rarely co-occurred, supporting the interpretation that distinct functional domains of the HLA-DR molecule are implicated in the pathomechanisms of these two autoimmune diseases.
Breast-milk jaundice.
Authors: T Hargreaves
Journal: BMJ (1970)

than a hundred countries where paraquat is now used, most of which have strict regula- tions governing the use of pesticides.In cases of human poisoning by paraquat, and in experimental animals, the highest concentrations are found in the kidneys and liver and though these organs show signs of damage there is no subsequent proliferation of any of their component cells.It would be expected that were induction of "near anaerobic conditions" a cause of the cellular reaction these organs would show more proliferation than the lungs.Measurement of ATP concentrations in paraquat poisoned animals also shows no change.There is therefore no parallel between Warburg's theory of carcinogenesis and the actions of paraquat as Drs.Stokes and Walker suggest.-Weare, etc.,