tbuckley/cabot-search huggingface dataset:
A rare case of hemobilia associated with aneurysms of the celiac trunk, the hepatic artery, and the splenic artery
Authors: G. Traversa, M. Zippi, A. Bruni, M. Mancuso, P. Di Stefano, G. Occhigrossi
Journal: Endoscopy (2006)

A 49-year-old woman presented with acute gastrointestinal hemorrhage. She had a history of a melena with negative gastroscopy and colonoscopy examinations. On admission, her hemoglobin level was 9.4 g/dl, and the indices of cholestasis and hepatic cytolysis were normal. Urgent gastroscopy revealed fresh blood in the duodenum without a clear source of bleeding, but subsequent duodenoscopy showed evidence of active bleeding from the papilla of Vater (Figure [1]). Abdominal computed tomography revealed a large thrombosed aneurysm of the splenic artery associated with aneurysms of the celiac trunk and of the common hepatic artery (Figure [2]). The melena persisted and so angiography was performed, which confirmed the presence of the three aneurysms (Figure [3]). Embolization was performed by the insertion of 38 metallic coils in the splenic artery, the gastric artery, and the celiac trunk. The aneurysms thrombosed completely, as shown in the angiographic control 2 weeks later (Figure [4]). The patient recovered well and was discharged 1 week later. No further bleeding was observed over 5 months of follow-up.
Oxidative albumin damage in chronic liver failure: Relation to albumin binding capacity, liver dysfunction and survival
Authors: Karl Oettl, Ruth Birner-Gruenberger, Walter Spindelboeck, Hans Peter Stueger, Livia Dorn, Vanessa Stadlbauer, Csilla Putz-Bankuti, Peter Krisper, Ivo Graziadei, Wolfgang Vogel, Carolin Lackner, Rudolf E. Stauber
Journal: Journal of Hepatology (2013)
Use of photoproteins as intracellular calcium indicators.
Authors: J R Blinks
Journal: Environmental Health Perspectives (1990)

The calcium-regulated photoproteins, of which aequorin is the best known, continue to be one of the most useful groups of intracellular Ca2+ indicators. They are self-contained bioluminescent systems that emit blue light in the presence of Ca2+ ions, can readily be purified intact, and are nontoxic when introduced into foreign cells. They have been used successfully as Ca2+ indicators in almost every kind of cell, but are most widely used in muscle cells because of their relative freedom from motion artifacts. Photoproteins have also been used in conjunction with microscopic image intensification to localize Ca2+ in cells. Their large molecular size makes them difficult to introduce into cells, but once there, they have the advantage of staying in the cytoplasm. Aequorin can be microinjected satisfactorily into single cells of almost any size, but a number of alternative methods for introducing photoproteins into cells have been developed in recent years. Disadvantages of the photoproteins for some applications include the nonlinear relation between [Ca2+] and light intensity, the modest speed with which they respond to sudden changes in [Ca2+], and the fact the Mg2+ antagonizes the effect of Ca2+. Native photoproteins consist of a mixture of isospecies, and there are differences in Ca2+ sensitivity and in kinetic properties--both among photoproteins and among the isospecies of a given photoprotein. The genes for several of the isospecies of aequorin have been cloned and expressed in E. coli. It seems reasonable to hope that genetic engineering techniques may soon make it possible to consider using, as Ca2+ indicators, rare isospecies or rare photoproteins that have optimal properties for particular applications.
Response to Letter Regarding Article, “Early Dual Versus Mono Antiplatelet Therapy for Acute Non-Cardioembolic Ischemic Stroke or Transient Ischemic Attack: An Updated Systematic Review and Meta-Analysis”
Authors: Ka Sing Lawrence Wong, Yilong Wang, Xinyi Leng, Chen Mao, Jinling Tang, Philip M.W. Bath, Hugh S. Markus, Philip B. Gorelick, Liping Liu, Wenhua Lin, Yongjun Wang
Journal: Circulation (2014)

Systematic Review and Meta-Analysis." 1 We agree that the results of the Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events (CHANCE) study and this meta-analysis may change the guidelines for stroke and transient ischemic attack treatment in future.However, we are not aware of any recent change of guideline that is based on the results of the CHANCE study in China.Dr Zhang also raised a very interesting question about any potential interaction between traditional Chinese herbal medicine and antithrombotic agents.However, it is beyond the scope of this meta-analysis to answer this question.
A Clinical Lecture on the Rhinoplastic Operation: Delivered in the Meath Hospital and Co. Dublin Infirmary
Authors: W. Stokes
Journal: BMJ (1899)

OF the plastic operations in surgery, those designed for thl restoration of a nose partially or completely lost are probably the least popular with operating surgeons.This doubtless is due to the fact that satisfactory reSults are so seldom found possible of attainmnent, even by surgeons of some experience and reputed dexterity.When, however, the cases selected are suitable, and the necessary ingenuity in design and skill in execution on the part of the operator are available, then such procedures are to be commended and should be
Chemotherapy for Lung Cancer
Authors: Alex E. Denes, Cary A. Presant
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 January 1979Chemotherapy for Lung CancerALEX E. DENES, M.D., CARY A. PRESANT, M.D.ALEX E. DENES, M.D.Search for more papers by this author, CARY A. PRESANT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-1-125 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their recent article Hansen and associates (1) state that the superiority of their four-drug therapy (CCNU, cyclophosphamide, methotrexate, vincristine) over the three-drug regimen (CCNU, cyclophosphamide, methotrexate) is "easily accepted as related to the use of vincristine." One aspect of their data leads us to question this conclusion and provokes several thoughts on their study.Patients with the longest survival (median, 256 days) were those responding to the four-drug regimen, a result that is easily accepted because these patients had the longest remissions (median, 186 days). It was therefore surprising to find that the survival of those...References1. HANSENDOMBERNOWSKYHANSENHIRSCH HPMF: Chemotherapy of advanced small-cell anaplastic carcinoma. Superiority of a four-drug combination to a three-drug combination. Ann Intern Med 89:177-181, 1978 LinkGoogle Scholar2. COHENCREAVENFOSSIECKBRODERSELAWRYJOHNSTONWILLIAMSMINNA MPBLOACJ: Intensive chemotherapy of small cell bronchogenic carcinoma. Cancer Treat Rep 61:349-353, 1977 MedlineGoogle Scholar3. ALEXANIONBERGASELMIGLIOREVAUGHNHOWE RDPWC: Melphalan therapy for plasma cell myeloma. Blood 31:1-10, 1968 CrossrefMedlineGoogle Scholar4. DEVITACANELLOSCHABNERSCHUINHUBBARDYOUNG VGBPSR: Advanced diffuse histiocytic lymphoma, a potentially curable disease. Lancet 1:248-250, 1975 CrossrefMedlineGoogle Scholar1. LAGAKOS S: Prognostic factors for survival time in inoperable lung cancer, in Lung Cancer, edited by STRAUSS MJ. New York, Grune and Stratton, 1977, pp. 271-280 Google Scholar2. HANSENDOMBERNOWSKYHIRSCH HPF: Staging procedures and prognostic features in small-cell anaplastic bronchogenic carcinoma. Semin Oncol 5:280, 1978 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington University School of Medicine St. Louis, MO 63110 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1979Volume 90, Issue 1Page: 125-126KeywordsCancer chemotherapyChemotherapyCyclophosphamideLung and intrathoracic tumorsMethotrexate Issue Published: 1 January 1979 PDF DownloadLoading ...
Thiazide-lnduced Rise in Serum Calcium and Magnesium in Patients on Maintenance Hemodialysis
Authors: MARCELO H. KOPPEL
Journal: Annals of Internal Medicine (1970)

Hydrochlorothiazide, 200 mg/day, was given orally for 2 to 4 weeks to 14 patients treated with maintenance hemodialysis for end-stage renal disease. Predialysis levels of serum calcium rose in 13 patients, and distinct hypercalcemia developed in 8 patients. Changes in serum levels of diffusible calcium paralleled those of total calcium concentrations. Predialysis levels of serum magnesium also rose during thiazide administration. The infusion of parathyroid extract, 1 unit/hr/kg of body weight for 10 hr, failed to ellcit a normal increase in serum calcium in most of the uremic patients who had a calcemic response to thiazides. These data demonstrate an extrarenal effect of thiazides on calcium and magnesium metabolism. It is proposed that the calcemic effect of thiazides in these patients may be due to potentiation of the action of parathyroid hormone on bone.
Future perspectives, applications and challenges of genomic epidemiology studies for food-borne pathogens: A case study of Enterohemorrhagic<i>Escherichia coli</i>(EHEC) of the O157:H7 serotype
Authors: Mark Eppinger, Thomas A Cebula
Journal: Gut Microbes (2014)

The shiga-toxin (Stx)-producing human pathogen Escherichia coli serotype O157:H7 is a highly pathogenic subgroup of Stx-producing E. coli (STEC) with food-borne etiology and bovine reservoir. Each year in the U. S., approximately 100,000 patients are infected with enterohemorrhagic E. coli (EHEC) of the O157:H7 serotype. This food-borne pathogen is a global public health threat responsible for widespread outbreaks of human disease. Since its initial discovery in 1982, O157:H7 has rapidly become the dominant EHEC serotype in North America. Hospitalization rates among patients as high as 50% have been reported for severe outbreaks of human disease. Symptoms of disease can rapidly deteriorate and progress to life-threatening complications such as Hemolytic Uremic Syndrome (HUS), the leading cause of kidney failure in children, or Hemorrhagic Colitis. In depth understanding of the genomic diversity that exists among currently circulating EHEC populations has broad applications for improved molecular-guided biosurveillance, outbreak preparedness, diagnostic risk assessment, and development of alternative toxin-suppressing therapeutics.
Tuberculosis infection among health care workers in Montreal.
Authors: K Schwartzman, V Loo, J Pasztor, D Menzies
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

We conducted a cross-sectional survey to estimate the prevalence of tuberculosis infection among health care workers at two downtown Montreal hospitals. Participants completed questionnaires, then underwent two-step tuberculin testing. Records of previous tuberculin tests and BCG vaccinations were reviewed. Charts of all tuberculosis patients admitted in 1992-93 were also reviewed. Air changes and direction of air flow in patient care areas were measured using tracer gas techniques and smoke tubes. Of 619 eligible workers, 522 participated (84%). 196 (38%) were tuberculin reactors; 23 (4%) had documented conversions. Inadequate ventilation and delays in diagnosis were identified at both hospitals. Comparing clinical with nonclinical personnel, the adjusted odds of a significant initial tuberculin reaction were 2.6 (95% confidence interval 1.3, 5.2), of a documented conversion 13.6 (1.4, 132), and of a booster reaction 0.9 (0.2, 3.6). Initial tuberculin reactivity was associated with male gender (p = 0.008), BCG vaccination (p = 0.0001), foreign birth (p = 0.007), age (p < 0.0001), and occupation (p = 0.02); conversion with male gender (p = 0.001) and occupation (p = 0.01); and boosting with older age (p = 0.02) and BCG vaccination (p = 0.001). Among clinical personnel at two hospitals, the prevalence of significant tuberculin reactions and of documented conversions was unexpectedly high.
Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH
Authors: Philippe Mathurin, Charles L Mendenhall, Robert L Carithers, Marie-Jose Ramond, Willis C Maddrey, Peter Garstide, Bernard Rueff, Sylvie Naveau, Jean-Claude Chaput, Thierry Poynard
Journal: Journal of Hepatology (2002)
Discontinuation of Use and Switching of Antidepressants
Authors: Scott A. Bull, X. Henry Hu, Enid M. Hunkeler, Janelle Y. Lee, Eileen E. Ming, Leona E. Markson, Bruce Fireman
Journal: JAMA (2002)

Although current depression treatment guidelines recommend continuing antidepressant therapy for at least 4 to 9 months, many patients discontinue treatment prematurely, within 3 months.To investigate the relationship between patient-physician communication and the continuation of treatment with antidepressants and to explore the demographics, adverse effects, therapeutic response, and frequency of follow-up visits.A total of 401 telephone interviews of depressed patients being treated with selective serotonin reuptake inhibitor (SSRI) therapy between December 15, 1999, and May 31, 2000, were conducted and 137 prescribing physicians completed written surveys from Northern California Kaiser Permanente health maintenance organization outpatient clinics.Patient-physician communication about therapy duration and about adverse effects; therapy discontinuation or medication switching within 3 months after start of SSRI therapy.Ninety-nine physicians (72%) reported that they usually ask patients to continue using antidepressants for at least 6 months, but 137 patients (34%) reported that their physicians asked them to continue using antidepressants for this duration and 228 (56%) reported receiving no instructions. Patients who said they were told to take their medication for less than 6 months were 3 times more likely to discontinue therapy (odds ratio [OR], 3.12; 95% confidence interval [CI], 1.21-8.07) compared with patients who said they were told to continue therapy longer. Patients who discussed adverse effects with their physicians were less likely to discontinue therapy than patients who did not discuss them (OR, 0.49; 95% CI, 0.25-0.95). Patients who reported discussing adverse effects with their physicians were more likely to switch medications (OR, 5.60; 95% CI, 2.31-13.60). Fewer than 3 follow-up visits for depression, adverse effects, and lack of therapeutic response to medication were also associated with patients' discontinuing therapy.Discrepancies exist between instructions that physicians report they communicate to patients and what patients remember being told. Explicit instructions about expected duration of therapy and discussions about medication adverse effects throughout treatment may reduce discontinuation of SSRI use. Our finding that patients with 3 or more follow-up visits were more likely to continue using the initially prescribed antidepressant medication suggests that frequent patient-physician contact may increase the probability that patients will continue therapy.
Retrospective study of technical aspects and complications of endoscopic submucosal dissection for laterally spreading tumors of the colorectum
Authors: T. Toyonaga, M. Man-i, T. Fujita, J. East, E. Nishino, W. Ono, Y. Morita, T. Sanuki, M. Yoshida, H. Kutsumi, H. Inokuchi, T. Azuma
Journal: Endoscopy (2010)

Background and study aims: Laterally spreading tumors – non granular type (LST-NG) are more often considered candidates for endoscopic submucosal dissection (ESD) than laterally spreading tumors – granular type (LST-G), because of their higher potential for submucosal invasion. However, ESD for LST-NG can be technically difficult. The aim of our study was to compare our ESD results for LST-NG and for LST-G.
Effects of glucose on hepatic conversion of aminonitrogen to urea in patients with cirrhosis: Relationship to glucagon
Authors: Ole Hamberg, Hendrik Vilstrup
Journal: Hepatology (1994)

Glucose reduces the hepatic conversion of aminonitrogen to urea, quantified by the functional hepatic nitrogen clearance (i.e., the slope of the linear relation between urea synthesis rate and blood alpha-aminonitrogen concentration). This is due to a direct effect of glucose and to inhibition of glucagon. In this study, the effect of glucose on functional hepatic nitrogen clearance was examined during spontaneous hormone responses and during hormonal control by somatostatin. In 7 control subjects (study 1) and 9 patients with cirrhosis (study 2), functional hepatic nitrogen clearance was assessed twice in each subject: during infusion of alanine and during alanine administration superimposed on a continuous glucose infusion (blood glucose, on average = 8.4 mmol/L). In study 3, 6 patients with cirrhosis had functional hepatic nitrogen clearance determined on three occasions: during infusions of alanine and of alanine superimposed on infusion of somatostatin with either euglycemia or hyperglycemia (blood glucose = 8.4 mmol/L). In the control subjects (study 1), functional hepatic nitrogen clearance was 32.5 +/- 1.9 L/hr, and glucose reduced it to 18.4 +/- 0.9 L/hr (p < 0.01). In the cirrhotic patients, functional hepatic nitrogen clearance was only 9.8 +/- 1.3 L/hr (p < 0.01 vs. controls), and glucose did not change it. In the control subjects, glucose reduced the glucagon response to alanine from 204 +/- 36 ng/L to 106 +/- 8 ng/L (p < 0.05). In the cirrhotic patients the mean fasting glucagon level was increased twofold (180 +/- 21 ng/L). The response to alanine increased to 968 +/- 265 ng/L; it was not reduced by glucose. In study 3, somatostatin and hyperglycemia reduced functional hepatic nitrogen clearance from 13.2 +/- 1.5 L/hr to 6.4 +/- 0.7 L/hr (p < 0.01). Somatostatin and euglycemia reduced functional hepatic nitrogen clearance to 9.2 +/- 1.2 L/hr (p < 0.01 vs. alanine and hyperglycemia). The results show that the reduction by glucose of hepatic aminonitrogen conversion is lost in cirrhotic patients. The markedly increased glucagon response to alanine was not suppressed by glucose. Inhibition of the glucagon response by somatostatin reestablished the glucose effect, which was in part due to inhibition of glucagon in itself. Thus hepatic aminonitrogen conversion in cirrhosis depends on increased glucagon levels. The hormone-independent effect of glucose is preserved if the hyperglucagonemia is abolished, but the spontaneous high glucagon level overrules the glucose effect. The results indicate reduced hepatic contribution to the nitrogen-sparing effect of glucose in cirrhotic patients.
The effects of a brace for patellofemoral osteoarthritis targeting knee pain and bone marrow lesions were overestimated or not?
Authors: Chao Zeng, Shu-guang Gao, Guang-hua Lei
Journal: Annals of the Rheumatic Diseases (2015)

We read with deep interest the article by Callaghan et al 1 related to the efficacy of patellar brace in patients with patellofemoral (PF) osteoarthritis (OA) targeting knee pain and bone marrow lesions (BMLs). To our best knowledge, patellar brace in the management of PF disorders, including PF arthritis, was first introduced in 1981.2 Since then only a few studies have examined the effects of patellar brace on the treatment of PF OA. This high-quality randomised controlled trial suggested that a PF brace reduced BML volume in the targeted compartment of the knee and relieved knee pain. These results were ‘promising’ in a situation where only a few conservative treatments have been consistently shown to affect structural findings. We really appreciate the work done …
An 8-Year-Old Boy With Autism, 1 Year Later
Authors: Richard A. Parker
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intravenous Infusion Filters-Reply
Authors: Kurt F. Schmidt
Journal: JAMA (1980)

<h3>In Reply.—</h3> One is usually somewhat blinded by one's own specialty (mine is anesthesiology), and we do not use the filters in the operating room that Mr Graybeal alludes to in his letter. I have been informed that other services do use such filters. A discussion is under way in this area as to the cost vs benefit of the routine use of such filters. To give an example, if every second patient admitted to our hospital would have an intravenous infusion, and if the added cost for one filter is $1, then the added patient care costs in our hospital for routine filtering would be about $70,000 a year. Such increases are not trivial and have to be looked at carefully.
Molecular biology and respiratory disease. 6. Modern molecular biology and respiratory bacterial infections: a revolution on the horizon.
Authors: T F Murphy
Journal: Thorax (1990)

Modern molecular biology and respiratory bacterial infectionsPotential advantages of analysis of lung secretions with DNA probes over conventional culture 1 Faster results. 2 Eliminates bacterial overgrowth as a problem. 3Quantitates bacteria more readily. 4In situ studies with tissue samples to confirm bacterial invasion.5 Identify selected serotypes associated with disease.
Evaluating Tele-ICU Reengineering of Critical Care Processes
Authors: H. A. Metske, P. E. Spronk, M. J. Schultz
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NOTES ON DYSENTERY VACCINATION
Authors: A. Castellani
Journal: BMJ (1916)

DYSENTERY Vaccination is of such great practical importance that one wonders that so little attention, com- paratively speaking, has been paid to it since the pioneer work of Kruse and Shiga.Such vaccination has never been used to any large extent, owing, I believe, to the following reasons:1. Vaccines containing the Shiga-Kruso bacillus, pre- pared according to the usual technique (brotli cultures killed by heat), give an extremiely severe local and general