Where Do We Stand on Drug Treatment for Ulcerative Colitis?
Authors: Burton I. Korelitz
Journal: Annals of Internal Medicine (1992)

Editorials15 April 1992Where Do We Stand on Drug Treatment for Ulcerative Colitis?Burton I. Korelitz, MDBurton I. Korelitz, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-8-692 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe best treatment for any disease process cannot be considered optimal without knowing the cause of the disease. This is certainly true of ulcerative colitis. Of the various modalities available for the treatment, some of which work some of the time, not one is effective in all cases. This is in keeping with the realization that the etiology of ulcerative colitis remains an enigma, despite the progress made in understanding the natural course, complications, surgical innovations, and overall management including drug therapy.Although ulcerative colitis is presumed to be an ancient disease, the first reports that convince us that it...References1. Kirsner J. Historical aspects of inflammatory bowel disease. J Clin Gastroenterol. 1988;10:286-97. CrossrefMedlineGoogle Scholar2. Svartz N. The treatment of 124 cases of ulcerative colitis with salazapyrine and attempts of desensitization in cases of hypersensitiveness to sulfa. Acta Med Scand. 1948;139(Suppl 206):465-72. Google Scholar3. MargolinKrumholzFochiosKorelitz MMSB. Clinical trials in ulcerative colitis: II. Historical review. Am J Gastroenterol. 1988;83:227-43. MedlineGoogle Scholar4. TrueloveWitts SL. Cortisone in ulcerative colitis. Final report on a therapeutic trial. Br Med J. 1955;2:104-8. CrossrefMedlineGoogle Scholar5. Lennard-JonesLongmoreNewellWilsonJones JAACF. An assessment of prednisone, salazapyrine and topical hydrocortisone hemisuccinate used as outpatient treatment for ulcerative colitis. Gut. 1960;1:217-27. CrossrefMedlineGoogle Scholar6. KorelitzLindner BA. The influence of corticotropin and adrenal steroids in the course of ulcerative colitis: comparison with presteroid era. Gastroenterology. 1964;46:671-9. CrossrefMedlineGoogle Scholar7. KirsnerPalmerSpencerBicksJohnson JWJRC. Corticotropin (ACTH) and the adrenal steroids in the management of ulcerative colitis: observations in 240 patients. Ann Intern Med. 1959;50:891-927. LinkGoogle Scholar8. Lennard-JonesMisiewiczConnellJones JJAF. Prednisone as maintenance treatment for ulcerative colitis in remission. Lancet. 1965;1:188-9. CrossrefMedlineGoogle Scholar9. Bean R. The treatment of chronic ulcerative colitis with 6-mercaptopurine. Med J Aust. 1962;28:592-3. CrossrefGoogle Scholar10. AdlerKorelitz DB. The therapeutic efficacy of 6-mercaptopurine in refractory ulcerative colitis. Am J Gastroenterol. 1990;85:717-22. MedlineGoogle Scholar11. PresentMeltzerKrumholzWolkeKorelitz DSWAB. 6-Mercaptopurine in the management of inflammatory bowel disease: short term and long term toxicity. Ann Intern Med. 1989;111:641-9. LinkGoogle Scholar12. StensonCortRodgers WDJ. Dietary supplementation with fish oil in ulcerative colitis. Ann Intern Med. 1992;116:609-14. LinkGoogle Scholar13. McCallO'LearyBloomfieldO'Morain TDJC. Therapeutic potential of fish oil in the treatment of ulcerative colitis. Aliment Pharmacol Ther. 1989;3:415-24. CrossrefMedlineGoogle Scholar14. SalomonKornbluthJanowitz PAH. Treatment of ulcerative colitis with fish oil in 3 omega fatty acid: an open trial. J Clin Gastroenterol. 1990;12:157-61. CrossrefMedlineGoogle Scholar15. FaberKorelitz SB. Use of asacol in treatment of inflammatory bowel disease. In: Korelitz BI, Sohn N; eds. Management of Inflammatory Bowel Disease. St. Louis: Mosby Year Book; 1992. Google Scholar16. LichtigerPresent SD. Cyclosporine in treatment of severe active ulcerative colitis. Preliminary report. Lancet. 1990;336:16-9. CrossrefMedlineGoogle Scholar17. KozarekPattersonGelfandBotomanBallWilske RDMVTK. Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease. Ann Intern Med. 1989;110:353-6. LinkGoogle Scholar18. LashnerHanauerSilverstein BSM. Testing nicotine gum for ulcerative colitis patients. Experience with single-patient trials. Dig Dis Sci. 1990;35:827-32. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Lenox Hill Hospital New York, NY 10021 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGastrointestinal Parameters That Influence Oral Medications 15 April 1992Volume 116, Issue 8Page: 692-694KeywordsDrug therapyDrugsEtiologyHospital medicineUlcerative colitis Issue Published: 15 April 1992 PDF DownloadLoading ...