tbuckley/cabot-search huggingface dataset:
Detection of Coxsackie B2 Virus Myocarditis in a Neonate Using Tl-201 and I-123 BMIPP Myocardial Imaging
Authors: TAKAHISA SAWADA, YOSHIO KOHNO, HITOSHI IKEGAMI, HISASHI TSUJII, HARUYASU IKUTA, HARUUMI OKABE, HIROKI SUGIHARA
Journal: Clinical Nuclear Medicine (2000)

Radionuclide imaging of myocardial perfusion and metabolism is rare in neonates, because preparation and image construction are difficult.The authors describe a 7-day-old boy with acute meningitis and myocarditis associated with Coxsackie B2 virus infection. In the acute phase, dual SPECT images of Tl-201 and I-123 β-methyliodophenyl pentadecanoic acid (I-123 BMIPP) clearly showed extensive defects in the inferoposterior wall of the left ventricle. The patient was treated successfully for 32 days during hospitalization and showed significant improvement of abnormal myocardial images in the chronic phase. Myocardial imaging provided useful information about the severity and recovery of Coxsackie B2 myocarditis.
Open cast mines and asthma
Authors: K. Anderson
Journal: BMJ (1993)

investigations without priority, selection criteria, or cost-benefit considerations.The brief mention of vesicoureteric reflux gives no indication of which adults require investigation, and both here and in respect of investigation for renal scarring there seems to be confusion with paediatric practice.'Are we really to believe that adults require dimercaptosuccinic (DMSA) scans?
Spinal Manipulation: When Is It Appropriate?
Authors: Marc S. Micozzi
Journal: Annals of Internal Medicine (1999)

Letters2 February 1999Spinal Manipulation: When Is It Appropriate?Richard A. Deyo, MD, MPHRichard A. Deyo, MD, MPHUniversity of Washington; Seattle, WA 98195Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-3-199902020-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:As one of the authors of the guidelines for acute low back problems sponsored by the Agency for Health Care Policy and Research (AHCPR), I was surprised to read Dr. Micozzi's conclusions about spinal manipulation in his editorial on complementary care (1). The first sentence of the editorial indicates that the AHCPR “made history when it concluded that spinal manipulative therapy is the most effective and cost-effective treatment for acute low back pain.” Although the guidelines are lengthy and complex, I cannot remember such a statement being included, and I specifically do not remember any cost-effectiveness analyses ...References1. Micozzi MS. Complementary care: when is it appropriate? Who will provide it? [Editorial]. Ann Intern Med. 1998;129:65-6. LinkGoogle Scholar2. Bigos SJ, Bowyer O, Braen G, Brown K, Deyo R, Haldeman S, et al. Acute low back pain problems in adults: clinical practice guideline #14. Rockville, MD: U.S. Department of Health and Human Services, Public Health Services, Agency for Health Care Policy and Research; 1992. AHCPR publication no. 95-0642. Google Scholar3. Carey TS, Garrett J, Jackman A, McLaughlin C, Fryer J, Smycker DR. The outcomes and costs of care for acute low back pain among patients seen by primary care practitioners, chiropractors, and orthopedic surgeons. The North Carolina Back Pain Project. N Engl J Med. 1995;333:913-7. CrossrefMedlineGoogle Scholar4. Shekelle PG, Markovich M, Louie R. Comparing the costs between provider types of episodes of back pain care. Spine. 1995;20:221-6. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Washington; Seattle, WA 98195 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoComplementary Care: When Is It Appropriate? Who Will Provide It? Marc S. Micozzi Spinal Manipulation: When Is It Appropriate? Marc S. Micozzi Metrics 2 February 1999Volume 130, Issue 3Page: 238KeywordsChiropracticClinical trialsHealth care policyLower back painPrimary care physiciansResearch quality assessmentTreatment guidelines Issue Published: 2 February 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
EXTRA-UTERINE PREGNANCY.Read in the Section of Obstetrics and Diseases of Women, at the Forty-second Annual Meeting of the American Medical Association, Washington, D. C., May 5, 1891.
Authors: DONNEL HUGHES
Journal: JAMA (1891)

In discussing the subject of extra-uterine pregnancy, it is advisable to begin by directing our attention to the locations at which fecundation takes place. There are three sites at which it is supposed to occur, viz.: the Fallopian tubes, the ovaries, and in the peritoneal cavity. There are several varieties of the three species just alluded to. The tubo-ovarian is that variety in which the germ is arrested in the pavilion (the tube adhering to the ovary). The tubo-abdominal, in which the germ is arrested in the same place as the tubo-ovarian, but instead of the tube being adherent to the ovary, it is adherent to any of the neighboring viscera. The tubai-proper is that form in which the germ is arrested in any part of the oviduct between the pavilion and that portion of the Fallopian tube that is surrounded by the uterine walls. The tubo-uterine, or interstitial variety,
Autoimmune chronic active hepatitis in a family.
Authors: S Hodges, A Lobo-Yeo, P Donaldson, M S Tanner, D Vergani
Journal: Gut (1991)

A positive family history of autoimmune disease is common among patients with autoimmune chronic active hepatitis, but usually autoimmunity is directed at organs other than the liver. We document for the first time the multiple occurrence of autoimmune chronic active hepatitis in a family. Out of a sibship of seven, three sisters developed this, one sister developed coeliac and autoimmune thyroid disease, one sister showed serological signs of autoimmunity, while the two brothers were well with no signs of autoimmunity. HLA typing showed that in association with the female sex DR3 seems to be more important than B8 in conferring susceptibility to autoimmune chronic active hepatitis, at least in this family.
TCT-180 Mid-Term Outcomes Following Endovascular Intervention for Iliac Artery In-Stent Restenosis
Authors: Usman Javed, Christopher Balwanz, Ehrin Armstrong, David Anderson, Caroline McCoach, Satinder Singh, Greg Westin, Khung Keong Yeo, John Laird
Journal: Journal of the American College of Cardiology (2012)
Intradural Spinal Cord Tumors
Authors: Ben Shofty, Akiva Korn, Zvi Lidar, Shlomi Constantini
Journal: Neuro-Oncology (2012)

Intradural spinal cord tumors (SCTs) compose a heterogeneous group of neoplasms. Over the past four decades, the overall mortality and morbidity caused by these tumors has been dramatically reduced. The advantages of early diagnosis via modern imaging and modern neurosurgical tools such as intraoperative electrophysiologic monitoring, the surgical microscope, and the ultrasonic aspirator have led to an improvement in surgical morbidity and in general prognosis. This chapter focuses on common intradural primary SCTs, both intramedullary and extramedullary.
State of Complementary and Alternative Medicine in Cardiovascular, Lung, and Blood Research
Authors: Michael C. Lin, Richard Nahin, M. Eric Gershwin, John C. Longhurst, Kenneth K. Wu
Journal: Circulation (2001)

The National Heart, Lung, and Blood Institute and the National Center for Complementary and Alternative Medicine recently cosponsored a workshop on the use of complementary and alternative medicine (CAM) in cardiovascular, lung, and blood research. In view of the increasing use of CAM by the general public, it is imperative to promote credible research by the established biomedical community. The goal of this workshop was to enhance the exchange of information and ideas between alternative medicine practitioners and scientists in cardiovascular, lung, and blood research and to foster collaborative research among these researchers. The workshop focused on 5 areas of research, including a historical and cultural perspective of CAM, methodological issues in clinical trials, herbal medicine, chelation therapy, mind/body (meditation) therapy, and acupuncture. CAM has become widely used without rigorously proven efficacy and safety. To protect the public, it was recommended that the fundamental mechanistic research for these CAM approaches be vigorously pursued and that any large-scale clinical trial be carefully executed to avoid any waste of resources and any unnecessary risk. It was felt that standardization of botanical products and procedure-based CAM intervention, such as acupuncture and meditation, is essential for meaningful basic and clinical research. Although botanical products properly consumed are perceived as generally safe, potential herb-drug interactions are a major safety concern. Clearly, many challenges need to be addressed by the scientific community before the public can be assured of the proper use of CAM.
Clinical relevance of sonometry-derived tumour thickness in malignant melanoma-a statistical analysis
Authors: J. TACKE, G. HAAGEN, O.P. HORNSTEIN, G. HUETTINGER, F. KIESEWETTER, H. SCHELL, T.L. DIEPGEN
Journal: British Journal of Dermatology (2006)

Journal Article Clinical relevance of sonometry‐derived tumour thickness in malignant melanoma—a statistical analysis Get access J. TACKE, J. TACKE Department of Dermatology, University of Erlangen, Hartmannstr. 14, 91052 Erlangen, Germany Search for other works by this author on: Oxford Academic Google Scholar G. HAAGEN, G. HAAGEN Department of Dermatology, University of Erlangen, Hartmannstr. 14, 91052 Erlangen, Germany Search for other works by this author on: Oxford Academic Google Scholar O.P. HORNSTEIN, O.P. HORNSTEIN Department of Dermatology, University of Erlangen, Hartmannstr. 14, 91052 Erlangen, Germany Search for other works by this author on: Oxford Academic Google Scholar G. HUETTINGER, G. HUETTINGER Department of Dermatology, University of Erlangen, Hartmannstr. 14, 91052 Erlangen, Germany Search for other works by this author on: Oxford Academic Google Scholar F. KIESEWETTER, F. KIESEWETTER Department of Dermatology, University of Erlangen, Hartmannstr. 14, 91052 Erlangen, Germany Search for other works by this author on: Oxford Academic Google Scholar H. SCHELL, H. SCHELL Department of Dermatology, University of Erlangen, Hartmannstr. 14, 91052 Erlangen, Germany Search for other works by this author on: Oxford Academic Google Scholar T.L. DIEPGEN T.L. DIEPGEN Department of Dermatology, University of Erlangen, Hartmannstr. 14, 91052 Erlangen, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 132, Issue 2, 1 February 1995, Pages 209–214, https://doi.org/10.1111/j.1365-2133.1995.tb05015.x Published: 01 February 1995 Article history Accepted: 11 January 1994 Published: 01 February 1995
Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity.
Authors: B Gansbacher, K Zier, B Daniels, K Cronin, R Bannerji, E Gilboa
Journal: The Journal of Experimental Medicine (1990)

To study the effects of localized secretion of cytokines on tumor progression, the gene for human interleukin 2 (IL-2) was introduced via retroviral vectors into CMS-5 cells, a weakly immunogenic mouse fibrosarcoma cell line of BALB/c origin. Secretion of low levels of IL-2 from the tumor cells abrogated their tumorigenicity and induced a long-lasting protective immune response against a challenge with a tumorigenic dose of parental CMS-5 cells. Co-injection of IL-2-producing CMS-5 cells with unmodified tumor cells inhibited tumor formation even when highly tumorigenic doses of CMS-5 cells were used. Cytolytic activity in mice injected with parental CMS-5 cells was transient and was greatly diminished 3 wk after injection, as commonly observed in tumor-bearing animals. However, in mice injected with IL-2-producing cells, tumor-specific cytolytic activity persisted at high levels for the duration of the observation period (at least 75 d). High levels of tumor-specific cytolytic activity could also be detected in parental CMS-5 tumor-bearing animals 18 d after inoculation with tumor cells, if IL-2-producing CMS-5 cells but not unmodified parental tumor cells were used as targets. These studies highlight the potential advantages of localized secretion of cytokines mediated via gene transfer to induce potent anti-tumor immune responses.
Acid Base Physiology in Medicine: A Self-Instruction Program
Authors: W. D. Snively
Journal: JAMA (1968)

The authors, eminently qualified in their field, have chosen programmed instruction to lead their readers through the jungle of acidbase disturbances. The target audience is a sophisticated one: medical specialists who want an integrated picture of acid-base physiology which can serve as a background for their clinical activities. But the subject presents formidable difficulties even under the best auspices. Most medical specialists will have to apply themselves industriously and repeatedly to understand the subject as here presented, especially if they are not mathematically oriented. Although the authors assert that they have avoided the mathematical approach —so repugnant to most physicians —many facets of the presentation involve mathematics. The course approaches the subject logically and systematically, first covering elementary physical chemistry, buffer systems, and the metabolic and respiratory contributions to acid-base balance. Then the program carries the reader through the clinical disturbances: metabolic alkalosis, respiratory acidosis, and respiratory alkalosis. The authors
Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group
Authors: C Fernández de Larrea, R A Kyle, B G M Durie, H Ludwig, S Usmani, D H Vesole, R Hajek, J F San Miguel, O Sezer, P Sonneveld, S K Kumar, A Mahindra, R Comenzo, A Palumbo, A Mazumber, K C Anderson, P G Richardson, A Z Badros, J Caers, M Cavo, X LeLeu, M A Dimopoulos, C S Chim, R Schots, A Noeul, D Fantl, U-H Mellqvist, O Landgren, A Chanan-Khan, P Moreau, R Fonseca, G Merlini, J J Lahuerta, J Bladé, R Z Orlowski, J J Shah
Journal: Leukemia (2012)
217 LONG-TERM FOLLOW-UP AFTER RADIOFREQUENCY ABLATION (RFA) FOR SMALL HEPATOCELLULAR CARCINOMA (HCC)
Authors: K. Hosoda, A. Yagawa, M. Hanawa, Y. Minai, S. Kobayashi, T. Yasumura, T. Ozawa, R. Iida
Journal: Journal of Hepatology (2010)
Increasing Sequence Correlation Limits the Efficiency of Recombination in a Multisite Evolution Model
Authors: S. Gheorghiu-Svirschevski, IM Rouzine, JM Coffin
Journal: Molecular Biology and Evolution (2006)

The accumulation of preexisting beneficial alleles in a haploid population, under selection and infrequent recombination, and in the absence of new mutation events is studied numerically by means of detailed Monte Carlo simulations. On the one hand, we confirm our previous work, in that the accumulation rate follows modified single-site kinetics, with a timescale set by an effective selection coefficient s(eff) as shown in a previous work, and we confirm the qualitative features of the dependence of s(eff) on the population size and the recombination rate reported therein. In particular, we confirm the existence of a threshold population size below which evolution stops before the emergence of best-fit individuals. On the other hand, our simulations reveal that the population dynamics is essentially shaped by the steady accumulation of pairwise sequence correlation, causing sequence congruence in excess of what one would expect from a uniformly random distribution of alleles. By sequence congruence, we understand here the opposite of genetic distance, that is, the fraction of monomorphic sites of specified allele type in a pair of genomes (individual sequences). The effective selection coefficient changes more rapidly with the recombination rate and has a higher threshold in this parameter than found in the previous work, which neglected correlation effects. We examine this phenomenon by monitoring the time dependence of sequence correlation based on a set of sequence congruence measures and verify that it is not associated with the development of linkage disequilibrium. We also discuss applications to HIV evolution in infected individuals and potential implications for drug therapy.
Serial Measurements of Mesothelioma Serum Biomarkers in Asbestos-Exposed Individuals: A Prospective Longitudinal Cohort Study
Authors: Kevin Hollevoet, Joris Van Cleemput, Joël Thimpont, Paul De Vuyst, Lionel Bosquée, Kristiaan Nackaerts, Paul Germonpré, Stijn Vansteelandt, Yoshiro Kishi, Joris R. Delanghe, Jan P. van Meerbeeck
Journal: Journal of Thoracic Oncology (2011)

Soluble mesothelin (SM) and megakaryocyte potentiating factor (MPF) are serum biomarkers of mesothelioma. This study aims to examine the longitudinal behavior of SM and MPF in controls to gain insight in the optimal use of these biomarkers in screening.Asbestos-exposed individuals, with no malignant disease at inclusion, were surveilled for 2 years with annual measurements of SM and MPF. Fixed thresholds were set at 2.10 nmol/L for SM and 13.10 ng/ml for MPF. Longitudinal biomarker analysis, using a random intercept model, estimated the association with age and glomerular filtration rate (GFR), and the intraclass correlation. The latter represents the proportion of total biomarker variance accounted for by the between-individual variance.A total of 215 participants were included, of whom 179 and 137 provided a second sample and third sample, respectively. Two participants with normal SM and MPF levels presented afterward with mesothelioma and lung cancer, respectively. Participants with elevated biomarker levels were typically older and had a lower GFR. During follow-up, biomarker levels significantly increased. Longitudinal analysis indicated that this was in part due to aging, while changes in GFR had a less pronounced effect on serial biomarker measurements. SM and MPF had a high intraclass correlation of 0.81 and 0.78, respectively, which implies that a single biomarker measurement and fixed threshold are suboptimal in screening.The longitudinal behavior of SM and MPF in controls indicates that a biomarker-based screening approach can benefit from the incorporation of serial measurements and individual-specific screening rules, adjusted for age and GFR. Large-scale validation remains nevertheless mandatory to elucidate whether such an approach can improve the early detection of mesothelioma.
Different functional and morphological characteristics in a nonadherent subpopulation of human macrophages recovered by bronchoalveolar lavage
Authors: CM Skold, C Barck, J Lundahl, A Johansson
Journal: European Respiratory Journal (1995)

The alveolar macrophages (AMs) constitute a morphologically and functionally heterogenous cell population. The adhesive properties of these cells are important for their role in host defence. To focus on the heterogeneity, a population of nonadherent macrophages were characterized functionally and morphologically. These cells were then compared with the total alveolar macrophage population. Alveolar cells (&gt; 95% alveolar macrophages), were recovered by bronchoalveolar lavage (BAL) from healthy smokers. Nonadherent macrophages were separated by adhesion. The phagocytic capacity and the autofluorescent properties of the cell populations were determined in flow cytofluorometric assays. In addition, electron microscopic evaluation was performed. The alveolar macrophage adhesion to wells coated with albumin increased in a time-dependent manner. After 15 min, median 47%, interquartile range 42-52% (uncoated wells 68%, 67-72%) of the alveolar macrophages were attached; and after 60 min, 56%, 51-58% (uncoated wells 73%, 71-76%) of the alveolar macrophages were attached. The nonadherent alveolar macrophage population had less phagocytic capacity. The cell autofluorescence increased with increasing cell size and cell complexity/granularity in both populations. The nonadherent cells were more autofluorescent, indicating an increased granularity/complexity. These findings were confirmed with electron microscopy. Thus, the nonadherent alveolar macrophages had more cytoplasmic inclusions than the total alveolar macrophage population (volume density median 0.39, interquartile range 0.35-0.46 and 0.31, 0.26-0.34, respectively), but less surface protusions. We conclude that in lavage fluid from human smokers there is an ultrastructurally specific subpopulation of alveolar macrophages, showing less adhesive properties and impaired phagocytic capacity in vitro. These macrophages may be older alveolar cells or, alternatively, airway macrophages. Since only alveolar macrophages from smokers were investigated, we cannot draw any conclusions regarding alveolar cells from nonsmokers. Nevertheless, the heterogeneity of the lavaged cells should be taken into consideration when the functional ability of the alveolar macrophages are evaluated.
The Repair of Umbilical Hernia: Unvoiced Assumptions and Sex-Reply
Authors: Anita Falla
Journal: JAMA (1988)

<h3>In Reply.</h3> —I responded to a letter that requested information and an opinion on the appropriate timing for the surgical repair of a persistent umbilical hernia in a child. I do know that many umbilical hernias spontaneously reduce and heal over a period of time. However, the need for making an adequate closure at the time of the beginning of a formal education, when physical activity becomes competitive, is one reason why timing of the child's surgery should occur just prior to the beginning of formal schooling. In addition, since in our society, and particularly here in the Northeast, girls at the postpubescent age may become pregnant and may do so as mature women, the integrity of the abdominal wall should be secure. We would not want an umbilical hernia to remain present during pregnancy. My response in no way had anything whatever to do with a moral or ethical