tbuckley/cabot-search huggingface dataset:
Talking with Donna
Authors: Nicole Martin
Journal: Annals of Internal Medicine (2004)

Ad Libitum7 September 2004Talking with DonnaNicole Martin, BSNicole Martin, BSFrom Boston, MA 02115.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-5-200409070-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail A mug of coffee is my muse, fuelingthe strings of words that emerge whenI open my mouth to explainwhy I'm thirty minutes lateSo sorry, I'm behind, busy dayA paper cup, steamingin a frail hand that spillsa puddle of liquid pain on the tableNo big deal, she says, I'll wipe it upBut the carpet's hit tooA beat of silence, and I take a swig that burnsin my chest as it slithers downShe raises her cup to coverthe mouth that's said so littlesince we met four months agofor the sugar and sludge ... Author, Article, and Disclosure InformationAffiliations: From Boston, MA 02115.Current Author Address: Nicole Martin, BS, Vanderbilt Box 021, 107 Avenue Louis Pasteur, Boston, MA 02115. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 7 September 2004Volume 141, Issue 5Page: 395KeywordsBurnsCoffeeHearingLower back painMouthPharynxSludgeThoraxTongue ePublished: 7 September 2004 Issue Published: 7 September 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Allergic reactions to betalactams: studies in a group of patients allergic to penicillin and evaluation of cross‐reactivity with cephalosporin
Authors: M. Audicana, G. Bernaola, I. Urrutia, S. Echechipia, G. Gastaminza, D. Muñoz, E. Fernández, L. Fernández de Corres
Journal: Allergy (1994)

A group of 34 penicillin‐allergic patients was studied to determine skin test reactivity to the different penicillins involved in inducing the allergic reaction and the cross‐reactivity with side‐chain‐related and side‐chain‐unrelated cephalosporins. All the subjects selected for the study had to be skin test positive to at least one of the following determinants: benzyl‐penicilloyl‐polylysine (BPO‐PLL), minor‐determinant mixture (MDM), amoxicillin (AX), or ampicillin (AMP), or to possess in vitro IgE to the following conjugates: benzyl‐penicilloyl‐human‐serum albumin (BPO‐HSA), ampicilloyl‐human‐serum albumin (AMP‐HSA), and amoxicilloyl‐human‐serum albumin (AX‐HSA). Cephalexin (CE) and ceftazidime (CEF) were used to assess cross‐reactivity. If skin tests to any of these compounds were positive, the patient was considered to be allergic; if negative, a challenge test was performed. Sixteen patients (47%) were skin test positive to BPO and/or MDM, and nine (26%) exclusively to AX and/or AMP. In three cases (8%), the RAST was positive although the skin test was negative; one to BPO‐HSA and two to AX‐HSA and AMP‐HSA. Six patients (17%) needed to be challenged with the penicillin involved to establish the diagnosis. In five patients (14%), the skin tests were positive to CE and in none to CEF. In all the others, the skin tests were negative to both cephalosporins, and the patients tolerated the drugs when challenged. These results indicate the relevance of side‐chain‐specific minor determinants in betalactams allergy and provide support for the role of this chemical structure in the evaluation of cross‐reactivity between penicillins and cephalosporins.
GMC clears former BMA chairman of most charges
Authors: C. Dyer
Journal: BMJ (2010)

The previous chairman of the BMA failed to take part in the postoperative care of several patients and failed to participate in multidisciplinary meetings to discuss patients’ care, a General Medical Council panel has held.

Jim Johnson, a former consultant surgeon at North Cheshire Hospitals NHS Trust, was also found guilty of failing to administer intraoperative heparin when he should have done and failing on one occasion to explain that an operation carried a risk of leg amputation.

The GMC’s fitness to practise panel also found that he agreed to perform a femoropopliteal bypass in one …
Smoking cessation in primary care
Authors: Sean P David, Marcus R Munafò
Journal: BMJ (2008)

eDITORIaLS Smoking cessation in primary careEvidence does not support routine use of combination therapy with nortriptyline being looked at by the Neonatal Data Analysis Unit. 8 The unit was formed to support and develop the use of electronic clinical data for audit, service evaluation, surveys, and research.It is only with information on appropriately case mix adjusted outcomes in near contemporaneous cohorts that parents, clinicians, and governments will be able to make truly informed decisions.
World's first public-private cord blood bank launched in United Kingdom
Authors: Susan Mayor
Journal: BMJ (2007)

Obstetricians and midwives are calling for discussions on the logistics of collecting umbilical cord blood for banking, after the launch of the world's first dual private and public cord blood stem cell bank in the United Kingdom. 

The Virgin Health Bank will provide parents with the facility to store their child's umbilical cord blood in two portions—one as a private sample for the sole use of the child and his or her family and the second as a public sample, available free of charge to anyone requiring stem cell transplantation. 

It is expected that around 80% of each sample will be placed in the public bank and 20% held in the private bank, although this will depend on the individual cord blood sample, stem cell expansion and whether cells meet the regulatory requirements for the international transplantation registry. 

Storage of umbilical cord blood has been growing in popularity over the past few years, with private banks being established in several countries. Umbilical cord blood is rich in stem cells, which can be used to treat patients with abnormal haematopoietic cell lines, childhood leukaemia, and a range of immune and metabolic diseases. Cord blood is cheaper and easier to …
FEMORAL HERNIA OF FALLOPIAN TUBE WITHOUT OVARY
Authors: CHARLES H. PARKES
Journal: JAMA (1910)

The intention in presenting this case is not to emphasize its rarity, however unusual the condition may be, but to call attention to the possibility of the occurrence and the necessity of its recognition at time of operation.  The literature on the subject has been covered by Dr. Frank T. Andrews1and Dr. Paul Morf2of Chicago up to the year 1907. It is therefore unnecessary at this time, to pursue that phase of the subject to any greater extent than to refer those interested to the articles mentioned. These writers—in their reports—present cases of their own to add to the list of the few on record.  Since the publication of Dr. Andrews' last paper on the subject in 1907, very few cases are to be found; in fact, I have been unable to discover any of the femoral and only three of the inguinal variety. In these
Overexpression of p300 correlates with poor prognosis in patients with cutaneous squamous cell carcinoma
Authors: M.-K. Chen, M.-Y. Cai, R.-Z. Luo, X. Tian, Q.-M. Liao, X.-Y. Zhang, J.-D. Han
Journal: British Journal of Dermatology (2014)

It has been suggested that the p300 transcriptional coactivator participates in the regulation of a wide range of cell biological processes, and mutations in p300 have been identified in various cancers.To investigate p300 expression in cutaneous squamous cell carcinoma (cSCC) tissues and its effect on the outcome of patients with cSCC.Immunohistochemistry (IHC) was performed on a tissue microarray to investigate p300 expression levels in cSCC tissues. Receiver operating characteristic (ROC) curve analysis, Kaplan-Meier plots and a Cox proportional hazards regression model were used to analyse the data.Based on the ROC curves, we defined the cut-off score for high p300 expression as > 55% of tumour cells positively stained. High expression of p300 was observed in 86 of 165 (52·1%) of the cSCC samples and six of 30 (20%) of the adjacent normal skin tissue samples (P < 0·001). High expression of p300 was positively correlated with lymph node metastasis (P = 0·006) and advanced clinical stage (P < 0·001). In univariate survival analysis, high expression of p300 was correlated with poor patient outcomes in terms of recurrence-free survival (P = 0·006) and overall survival (P < 0·001). Moreover, p300 expression was evaluated as an independent prognostic factor in a multivariate analysis (P = 0·004).Our results indicate that high p300 expression is associated with aggressive features of cSCC and suggest that p300 expression, as examined by IHC, will be a promising biomarker for predicting clinical outcomes in patients with cSCC.
Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis
Authors: Stephen Trzeciak, Jonathan V. McCoy, R. Phillip Dellinger, Ryan C. Arnold, Michael Rizzuto, Nicole L. Abate, Nathan I. Shapiro, Joseph E. Parrillo, Steven M. Hollenberg
Journal: Intensive Care Medicine (2008)
Abstract 4317: Low dose arsenic-induced transient p53 inhibition: A novel strategy for chemotherapy protection
Authors: Suthakar Ganapathy, Seo Seog-Jin, Chul Soo Ha, Zhi-Min Yuan
Journal: Cancer Research (2011)

Abstract Because of its effectiveness in killing cancer cells, chemotherapy remains to be one of the common modalities for cancer treatment, but the resulting severe side effects often pose a significant threat to cancer patients. Recognizing p53 activation in the sensitive tissues as the primary mechanism for chemotherapy-induced acute toxicity and the universal p53 inactivation in human cancers, we exploited the use of low dose arsenic to inhibit p53 for a selective protection of normal tissues from chemotherapeutics-induced damages. Colon carcinoma cell line SW-480 was used to generate a mouse xenograft model. Treatments were initiated three weeks after implantation when the tumor size reached approximately 100 mm3. Arsenic pretreatment was carried out by feeding sex-matched mice (4-6 weeks of age) with water (1.0 mg/L) for three days. As expected, treatment of tumor-bearing mice with 5FU for 7 days resulted in 77% decrease in tumor volume when compared with the untreated group. The brief treatment with low doses of arsenic did not affect the ability of 5FU to induce tumor regression as evidenced by an 80% reduction of tumor size. However, arsenic treatment was associated with a marked alleviation of 5FU-induced systemic toxicity as demonstrated by the finding that arsenic pretreatment reduced 5FU-induced body weight loss from 25% to 4%. The protecting effect of arsenic was also clearly evident in reducing 5FU-induced damage in gastrointestinal (GI) track and hematopoietic (HP) system, two of the most sensitive tissues. Using mutant p53 expressing mice, we demonstrate that arsenic-mediated protection primarily depends on functional p53. Our preclinical study implicates that the brief use of low doses arsenic to inhibit p53 is an effective approach of chemotherapy protection. If successfully validated in clinical studies, this strategy may not only minimize side effects, but would also allow escalated therapeutic doses to improve treatment efficacy in a safe and effective approach for cancer therapy protection. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4317. doi:10.1158/1538-7445.AM2011-4317
Failure of glucagon to influence ion transport across human jejunal and ileal mucosa in vitro.
Authors: P E Isaacs, L A Turnberg
Journal: Gut (1977)

Glucagon (90 to 880 pg.ml-1) failed to influence electrical activity or fluxes of sodium and chloride across human jejunal and ileal mucosa in vitro. These results suggest that the intestinal secretion and diarrhoea produced in vivo in man during intravenous infusion of glucagon may be produced by changes in motility and blood flow and not directly by activating an ion secretory mechanism as is the case in cholera.
Role of Sympathetic Nerve in Cancerous Pain
Authors: M. Dargent
Journal: BMJ (1948)

There is at present no clinical test available which will enable us to judge the position exactly, but it is probable that a periodic thorough and careful investigation of the retinal arteries by a skilled ophthalmologist is likely to provide the best guide to whether the onset of arterial degeneration is beginning to threaten.A periodic careful investigation of the renal function is also desirable in such cases.Finally, every case must be considered on its indi- vidual merits-general, cardiological, renal, familial, and psychological.
Poor areas lose out most in new NHS budget allocation
Authors: B. Barr, D. Taylor-Robinson
Journal: BMJ (2014)

As reported in the BMJ , NHS England has included a “deprivation indicator” in the new resource allocation formula for Clinical Commissioning Groups (CCGs).1 This follows concerns about an earlier proposed version of the formula, which would have shifted resources from poor areas with the worst health to more affluent areas with better health.2 We used data provided …
ON A SPECIFIC SUBSTANCE OF THE CHOLERA VIBRIO
Authors: K. Landsteiner, Philip Levine
Journal: The Journal of Experimental Medicine (1927)

The investigations described show that it is possible to extract specific substances from V. cholerae by means of hot dilute alcohol. This result cannot be attributed to the presence of bacilli in the extracts as would follow from the statements made by Prausnitz in his criticism of the work of Levaditi. The original extract contains protein and exhibits antigenic properties. From this preparation an almost protein-free product was obtained. It was fully active in the precipitin test but had lost almost completely the antigenic activity. Accordingly the latter preparation belongs to the class of substances described by Zinsser as residue antigens and studied chemically by Avery and Heidelberger. The fact that the immune sera resulting from the injections of the crude extracts acted upon the non-immunizing precipitable substance indicates that in the crude extract there is present an antigenic complex consisting of protein and the specific substance. Regarding its chemical nature it follows from the foregoing that the precipitable but non-immunizing substance is not a protein. On hydrolysis it yielded a considerable quantity of sugar although less than that given for the specific carbohydrates of pneumococci and B. friedlaenderi. The product contains nitrogen and phosphorus and on hydrolysis a substance of acid character separates from the solution. Accordingly the substance prepared would appear to have either a rather intricate structure or to be a complex carbohydrate, similar to those described by Avery and Heidelberger, but still containing impurities. This issue can probably be decided by further studies.
The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes
Authors: Gérard Waeber, Jérôme Delplanque, Christophe Bonny, Vincent Mooser, Myriam Steinmann, Christian Widmann, Anne Maillard, Judith Miklossy, Christian Dina, El H Hani, Gérard Waeber, Jérôme Delplanque, Nathalie Vionnet, Pascal Nicod, Philippe Boutin, Philippe Froguel
Journal: Nature Genetics (2000)
Thebesian Drainage in the Left Heart of the Dog
Authors: THOMAS W. MOIR, THOMAS E. DRISCOL, RICHARD W. ECKSTEIN
Journal: Circulation Research (1964)

Direct left heart drainage from the common left coronary artery has been demonstrated in the normally beating dog heart by an isotope dilution technique. The major portion of this drainage has been shown to be through the left circumflex branch of the common left coronary artery. The left anterior atrial artery, a branch of the left circumflex, has in turn been shown to be the major pathway of drainage from the latter. Left heart drainage could not be demonstrated from isotope injections into the left anterior descendens artery, and in only one preparation could such drainage be documented from the septal branch of the common left artery. The magnitude of left heart Thebesian drainage has been estimated by analysis of time-concentration curves recorded from the aorta. An average of 2% of total common left coronary artery inflow drains directly into the left heart. Although the major drainage is probably into the left atrium, left ventricular drainage has not been excluded.
AT-09 * BEVACIZUMAB AND GLIOBASTOMA OF THE ELDERLY: A SINGLE-CENTER RETROSPECTIVE ANALYSIS
Authors: E. Barrascout, M. Lamuraglia, C. Gervais, M. Tiako, S. Gaillard, S. Aldea, M. Mabro, J. Gachet, C. Theodore
Journal: Neuro-Oncology (2014)

PURPOSE: The primary objective of this study was to determine any difference in progression free survival (PFS), overall survival (OS), clinical benefit and tolerability between elderly and non-elderly patients receiving bevacizumab at recurrence for glioblastoma in a single center. PATIENTS AND METHODS: We retrospectively analyzed 32 patients with recurrent glioblastoma receiving bevacizumab (10 mg/kg every 14 days) between January 2011 and December 2013 in second line. Bevacizumab was introduced for all patients at recurrence after a treatment of first line by temozolomide. A cohort of 14 patients was older than 70 years against 18 patients were under 70 years. RESULTS: No statistically significant difference was detected in terms of PFS and OS. PFS was 2.8 months for elderly patients against 2.9 for non-elderly patients (p >0.5). OS from recurrence in elderly and non-elderly patients was respectively 4.3 and 5.5 months (p >0,5). Clinical improvement in neurological symptoms was observed in 3 of 14 elderly patients (21.1%) and 11 of 18 young patients (61.1%). A more important improvement in performance status was observed in young patients. Regarding toxicity, 3 of the 14 elderly patients experienced grade II or III hypertension. In younger patients, 5 adverse events have been observed (2 proteinuria, 1 hypertension, 1 hemorrhage and 1 anal abscess). CONCLUSION: Despite small number of patients in this retrospective study, the efficacy and safety of bevacizumab in recurrent glioblastoma appears similar in elderly and non-elderly patients. However, clinical benefit seemed to be less important in elderly patients. A prospective multicentric study integrating geriatric assessment tools and quality of life would be interesting in this patient's population.
Postgraduate Medicine in London — The Art of Self-Criticism — Working Mothers
Authors: John Lister
Journal: New England Journal of Medicine (1956)

THE Postgraduate Medical School of London received its Royal Charter twenty-five years ago. Ten years previously the first Minister of Health, Dr. Christopher Addison, had appointed a committee to investigate the needs of medical graduates for further education in London. It was upon the recommendation of this committee that the Postgraduate Medical School was established at Hammersmith Hospital. Although early development was hampered by the financial crisis of 1931 and further expansion was delayed by World War II the achievements of the school in the twenty-five years of its existence have been considerable.When opening the school in 1935, King . . .
New guidance on ECT looks set to curb its use
Authors: C. White
Journal: BMJ (2003)

New guidance for England and Wales on the use of electroconvulsive therapy (ECT) threatens to exclude many people who might benefit from it and to pose difficulties for clinicians, claim specialist psychiatrists.

The guidance, which was issued last week by the National Institute for Clinical Excellence (NICE), restricts the use of ECT to the rapid and short term relief of severe depressive or manic symptoms and catatonia after all other treatment options have failed and suicide is a risk.

But the Royal College of Psychiatrists' special committee on ECT, supported by the Scottish ECT …
STUDIES ON THE CIRCULATION IN MAN
Authors: G. N. Stewart
Journal: The Journal of Experimental Medicine (1915)

1. In cases in which great inequalities in the blood flow in the two hands were produced by mechanical causes (ligation or compression of vessels, embolism), the stability of the ratio of the flows, in successive measurements at short intervals, was found to be characteristic. Over long intervals the opening up of collateral circulation or the progressive increase of the block (in a case of multiple embolism with thrombosis) was followed by changes in the ratio of the blood flows in the normal and the affected part. Another criterion of these conditions was found to be that the inequality was not abolished by producing general vasomotor changes; e. g., by altering the external temperature. 2. In certain cases inequalities in the blood flow in the two hands (or feet) were found which were not stable from day to day, and which could be abolished, reduced, increased, or reversed by alterations in the external conditions which bring about general vasomotor changes. These inequalities, not associated with clinically recognizable differences between the parts compared, were interpreted as due to unequal activity of the vasomotor mechanism on the two sides. The condition appeared to be most frequent in certain groups of neurological cases.
Asthma Deaths and Aerosol Propellants
Authors: Millard Bass
Journal: JAMA (1971)

<h3>To the Editor.—</h3> In the current controversy concerning the asthma death rate in North America, some medical reports have noted the asthma death rate to be on the increase, while others have simultaneously noted a decrease.<sup>1-3</sup>The confusion concerning asthma death rates stems in part from over-simplified methods of data collection and interpretation of hospital mortality reports as well as death certificates gathered by the National Center for Health Statistics. With the increased awareness of pulmonary emphysema and chronic bronchitis, and with the advent of new diagnostic tools and techniques in the area of cardiopulmonary research, diagnoses other than asthma can now be established. On the basis of death certificate information, and without clinical and autopsy data, it is difficult to determine if asthma deaths in the United States were underreported and pulmonary emphysema and bronchitis overreported in the middle and late 1960s. In addition to the controversy over