tbuckley/cabot-search huggingface dataset:
Lung Function: Assessment and Application in Medicine
Authors: Theodore Rodman
Journal: JAMA (1965)

The subject matter and literary style of this book are excellently characterized by its pithy title<i>Lung Function</i>. It is probably the most complete and concise account so far published devoted to this subject and the techniques available for its assessment. There are outstanding sections on the historical aspects of lung diseases; the subdivisions of the lung volumes; the distribution of ventilation and perfusion, particularly the differences in respiratory exchange rates and alveolar-toarterial nitrogen gradients; and an excellent discussion of factors that limit exercise. There are also reasonably good accounts of such subjects of recent investigative interest as the use of hyperbaric oxygenation, application of gas chromatographic and electrode techniques for respiratory gas analysis, the surface active properties of lung tissue, the effect of respiratory gas and hydrogen-ion concentration on the pulmonary circulation, and the use of radioactive gases to evaluate pulmonary function. In general, however, this book lacks the
CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.
Authors: A Davies, D L Simmons, G Hale, R A Harrison, H Tighe, P J Lachmann, H Waldmann
Journal: The Journal of Experimental Medicine (1989)

A novel cell surface antigen has been identified on a wide range of lymphoid cells and erythrocytes. A mAb YTH 53.1 (CD59) against this antigen enhanced the lysis of human red cells and lymphocytes by homologous complement. Studies of reactive lysis using different species of C56, and of whole serum used as a source of C7-9, indicated that the inhibitory activity of the CD59 antigen is directed towards the homologous membrane attack complex. CD59 antigen was purified from human urine and erythrocyte stroma by affinity chromatography using the mAb YTH 53.1 immobilized on Sepharose, and, following transient expression of a human T cell cDNA library in COS cells, the corresponding cDNA also identified using the antibody. It was found that the CD59 antigen is a small protein (approximately 20 kD as judged by SDS-PAGE, 11.5 kD predicted from the isolated cDNA) sometimes associated with larger components (45 and 80 kD) in urine. The sequence of CD59 antigen is unlike that of other complement components or regulatory proteins, but shows 26% identity with that of the murine LY-6 antigen. CD59 antigen was released from the surface of transfected COS cells by phosphatidylinositol-specific phospholipase C, demonstrating that it is attached to the cell membrane by means of a glycolipid anchor; it is therefore likely to be absent from the surface of affected erythrocytes in the disease paroxysmal nocturnal hemoglobinuria.
Changes in cerebral blood flow during a migraine attack.
Authors: J W Norris, V C Hachinski, P W Cooper
Journal: BMJ (1975)

Regional cerebral blood flow studies during a typical prodromal phase of a migraine attack in a young woman showed a global decrease of cerebral blood flow in the carotid artery territory. These studies were repeated during the subsequent headache phase of the same attack and hemispheric blood flow increased considerably. Ergotamine tartrate was then administered intramuscularly which brought definite relief of symptoms but no change in cerebral blood flow. Carotid angiography performed immediately afterwards showed retrograde filling of the proximal portion of the basilar artery, which suggested that the brain stem was the site of hyper-perfusion. These findings illustrate certain features underlying both the pathophysiology of migraine itself and its response to ergotamine preparations.
Prediction of the rodent carcinogenicity of organic compounds from their chemical structures using the FALS method.
Authors: I Moriguchi, H Hirano, S Hirono
Journal: Environmental Health Perspectives (1996)

Fuzzy adaptive least-squares (FALS), a pattern recognition method recently developed in our laboratory for correlating structure with activity rating, was used to generate quantitative structure-activity relationship (QSAR) models on the carcinogenicity of organic compounds of several chemical classes. Using the predictive models obtained from the chemical class-based FALS QSAR approach, the rodent carcinogenicity or noncarcinogenicity of a group of organic chemicals currently being tested by the U.S. National Toxicology Program was estimated from their chemical structures.
Perthes' disease of the hip in Liverpool.
Authors: A J Hall, D J Barker, P H Dangerfield, J F Taylor
Journal: BMJ (1983)

A survey of Perthes9 disease of the hip in three regions of England showed a higher incidence in the Mersey region compared with Trent or Wessex. To explore this further a case register was set up in Liverpool. Analysis of all new cases that occurred in Liverpool and adjacent parts of Knowsley and Sefton during 1976-81 showed a steep gradient with social class, ranging from 7.7/100 000 children in the higher classes to 26.3/100 000 in social class V. The inner city of Liverpool, which has been shown to be underprivileged, had the highest yearly incidence of the disease ever reported--21.1 cases/100 000 children aged 14 years and under. The associations with poverty support the hypothesis that undernutrition is a causative factor in the disease.
Inhibition of Stimulated Gastric Secretion by an Orally Administered Prostaglandin Capsule
Authors: DONALD E. WILSON
Journal: Annals of Internal Medicine (1976)

The effect of ingestion of a gelatin capsule containing 127 µg of 16,16-dimethyl prostaglandin E2 (DM-prostaglandin E2) or a liquid containing 127 µg of DM-prostaglandin E2 on stimulated gastric secretion in man was studied. DM-prostaglandin E2 significantly reduced the volume, acid concentration, and total acid output of gastric secretion. Secretory inhibition during the 3 h after treatment with the capsule was 37% (volume), 39% (acid concentration), and 60% (acid output). The DM-prostaglandin E2 capsule was nearly as effective as an equivalent amount of DM-prostaglandin E2 in solution. Prostaglandin analogues, because of their oral effectiveness and duration of action, may have therapeutic value in peptic ulcer disease.
Posterior Mediastinal Mass in a Black Patient With Back Pain
Authors: Xavier Bosch
Journal: JAMA (1989)

<h3>HISTORY</h3> A 32-year-old black African man, living in Spain for the past month, was admitted to our hospital with asthenia, fever, and lower thoracic pain in the back radiating to the epigastrium. The pain was of 2 months' duration. Previous medical history was unremarkable. On admission, physical examination revealed an apparently healthy man with a temperature of 38°C, pulse rate of 94 beats per minute, and blood pressure of 140/70 mm Hg. Except for mild pain on percussion of the thoracic spine, results of physical examination were normal. Neurological examination showed no abnormalities. Laboratory studies revealed an erythrocyte sedimentation rate of 125 mm/h and a mild normochromic, normocytic anemia. In addition, antibodies against human immunodeficiency virus were not demonstrated by both enzyme-linked immunosorbent assay and Western blot testing. A posteroanterior chest film obtained at admission (Fig 1) showed an apparent right hilar mass with sharp margins. It was possible to
Sustained inhibition of intimal thickening. In vitro and in vivo effects of polymeric beta-cyclodextrin sulfate.
Authors: W B Bachinsky, E S Barnathan, H Liu, S S Okada, A Kuo, P N Raghunath, M Muttreja, R J Caron, J E Tomaszewski, M A Golden
Journal: Journal of Clinical Investigation (1995)

Intimal thickening after vascular injury may be modulated in part by heparin binding growth factors. We hypothesized that placement of a therapeutic polymer in the periadventitial space capable of tightly binding growth factors might alter the vascular response to injury. We first demonstrated that incubation of rat aortic smooth muscle cells with an insoluble, sulfated polymer of beta-cyclodextrin (P-CDS) was associated with a dose-dependent inhibition of proliferation induced by fetal calf serum, fibroblast growth factor-2 (FGF-2), platelet-derived growth factor BB, or epidermal growth factor. Preincubation studies of P-CDS with FGF-2 revealed a very rapid removal of mitogenic activity. Using radiolabeled FGF-2 (0.25 microg/ml), we observed a very rapid association rate (0.34 +/- 0.07 min-1, n=4) and a very slow dissociation rate (3.3 +/- 0.2 X 10(-7) min-1) at 37 degrees C, suggesting a high affinity interaction. Using both Transwell and linear under-agarose assays, we demonstrated a significant inhibition of random migration (chemokinesis) by P-CDS. Unsulfated polymeric beta-cyclodextrin (P-CD) had little if any of these effects, suggesting that the high negative charge density of P-CDS was important for the effects. Finally, rats undergoing carotid artery balloon injury were randomized to treatment with periadventitial P-CDS or no treatment, and were killed at 4 (n=20), 14 (n=59), and 88 d (n=14). Morphometric analysis demonstrated significant and sustained inhibition of intimal thickening in P-CDS-treated rats at 14 (P < 0.01) and 88 d (P < 0.05) using absolute intimal area or intima/media area ratios. No inhibition was seen in a group of rats treated with P-CD. In P-CDS-treated rats, bromodeoxyuridine labeling studies revealed fewer labeled smooth muscle cells in the intima at 14 d (P=0.01), while staining with Evans blue revealed enhanced late endothelial cell regrowth. Thus, periadventitially applied sulfated beta-cyclodextrin polymer, which can tightly bind heparin binding growth factors, inhibits intimal thickening in vivo in a sustained fashion without using an additional delivery system. These studies suggest that cellular processes mediated by heparin binding growth factors may be modulated by P-CDS.
JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration
Authors: Abigail Woodfin, Christoph Andreas Reichel, Andrej Khandoga, Monica Corada, Mathieu-Benoit Voisin, Christoph Scheiermann, Dorian O. Haskard, Elisabetta Dejana, Fritz Krombach, Sussan Nourshargh
Journal: Blood (2007)
Gallium 67 Concentration In Human Breast Milk
Authors: Steven M. Larson
Journal: JAMA (1971)

<h3>To the Editor.—</h3> In a previous article inThe Journal, the use of tumor-specific gallium citrate Ga 67 for the detection of neoplasms by photoscanning was reported.<sup>1</sup>As with any new clinical scanning procedure, an understanding of the physiologic behavior and normal anatomic distribution of the radionuclide is important for proper interpretation of the studies. We have observed the unusual localization of gallium 67 in the breasts of a 25-year-old postpartum woman, in whom the diagnosis of Hodgkin's disease had been made one week prior to delivery by biopsy of an enlarged cervical lymph node. Three weeks postpartum, the patient received an intravenous dose of 3.0 millicuries of gallium citrate Ga 67. Forty-eight hours later, a whole-body scan was performed which showed uptake of the tracer by both breasts (Figure). The patient had not nursed her infant, nor had she received hormones to suppress lactation. She was able to
Biologic and Clinical Importance of Proinsulin
Authors: David C. Robbins, Howard S. Tager, Arthur H. Rubenstein
Journal: New England Journal of Medicine (1984)

IN 1953 Sanger and Thompson described the complete covalent structure of insulin, a hormone containing two separate peptide chains and three disulfide bonds.1,2 Although proposed models for the biosynthesis of such a complex molecule were debated for many years, it was not until 1967 that the mechanism for insulin biosynthesis was finally elucidated: using an in vitro system containing isolated pancreatic islets or human insulinoma tissue and Radio-labeled amino acids, Steiner and his colleagues showed that the formation of insulin was preceded by the biosynthesis of a single-chain insulin-containing peptide about 1 1/2 times the size of insulin itself.3,4 Isolation . . .
DECREASED HIGH DENSITY LIPOPROTEIN CHOLESTEROL IN A COHORT OF 6TH-GRADE CHILDREN: ASSOCIATION WITH CARDIOVASCULAR RISK FACTORS AND LIFESTYLE BEHAVIORS
Authors: Shannon Flynn, Roopa Gurm, Jean DuRussel-Weston, Susan Aaronson, Lindsey Gakenheimer, Joe Smolarski, Daniel Simhaee, Nicole Corriveau, Cathy Fitzgerald, Taylor Eagle, Ravi Rao, Kim A. Eagle, Caren Goldberg, Elizabeth A. Jackson
Journal: Journal of the American College of Cardiology (2011)
Electrocardiographic Findings Among the Total Adult Population of a Large Religious Isolate
Authors: ALBERTO N. GOLDBARG, THADDEUS W. KURCZYNSKI, HERMAN K. HELLERSTEIN, ARTHUR G. STEINBERG
Journal: Circulation (1970)

Electrocardiograms were recorded as part of a survey of 1,303 men and 1,348 women past 15 years of age belonging to a large religious isolate inhabiting regions of northwestern U.S.A. and southwestern Canada. The ECGs were classified according to the Minnesota Code and the abnormalities were related to constitutional characteristics, blood pressure, and serum cholesterol. Major codable ECG items included abnormal Q waves (54 cases), abnormal left axis deviation (44 cases), bundle-branch block (left 10, right 10), T-wave abnormalities (257 cases), prolonged P-R interval (80 cases), and occasional premature beats (143 cases) and showed no significant sex differences. ST-segment depressions were more common among females ( P &lt; 0.005). The males showed a significantly higher frequency of increased R-wave amplitude ( P &lt; 0.005) and more qualitative T-wave changes ( P &lt; 0.005). In general, abnormal ECG features were associated with age, sex, and blood pressure, but not with serum cholesterol, body weight and height, skin-fold thickness, or arm girth. A notable exception was the negative relationship of body weight to high amplitude R waves in young males. In clinical practice, age and sex stratifications will improve the diagnostic power of the ECG.
Use of Emergency Medical Service Transport Among Patients With ST-Segment–Elevation Myocardial Infarction
Authors: Robin Mathews, Eric D. Peterson, Shuang Li, Matthew T. Roe, Seth W. Glickman, Stephen D. Wiviott, Jorge F. Saucedo, Elliott M. Antman, Alice K. Jacobs, Tracy Y. Wang
Journal: Circulation (2011)

Background— Activation of emergency medical services (EMS) is critical for the early triage and treatment of patients experiencing ST-segment–elevation myocardial infarction, yet data regarding EMS use and its association with subsequent clinical care are limited. Methods and Results— We performed an observational analysis of 37 634 ST-segment–elevation myocardial infarction patients treated at 372 US hospitals participating in the National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry–Get With the Guidelines between January 2007 and September 2009, and examined independent patient factors associated with EMS transportation versus patient self-transportation. We found that EMS transport was used in only 60% of ST-segment–elevation myocardial infarction patients. Older patients, those living farther from the hospital, and those with hemodynamic compromise were more likely to use EMS transport. In contrast, race, income, and education level did not appear to be associated with the mode of transport. Compared with self-transported patients, EMS-transported patients had significantly shorter delays in both symptom-onset-to-arrival time (median, 89 versus 120 minutes; P &lt;0.0001) and door-to-reperfusion time (median door-to-balloon time, 63 versus 76 minutes; P &lt;0.0001; median door-to-needle time, 23 versus 29 minutes; P &lt;0.0001). Conclusions— Emergency medical services transportation to the hospital is underused among contemporary ST-segment–elevation myocardial infarction patients. Nevertheless, use of EMS transportation is associated with substantial reductions in ischemic time and treatment delays. Community education efforts are needed to improve the use of emergency transport as part of system-wide strategies to improve ST-segment–elevation myocardial infarction reperfusion care.
730 PROTEOMICS BIOMARKERS PREDICTING HISTOLOGIC NON-ALCOHOLIC STEATOHEAPTITIS AND FIBROSIS
Authors: Z. Younossi, A. Baranova, M. Stepanova, V.S. Calvert, A. Afendy, Z. Goodman, L. Liotta, E. Petrocoins
Journal: Journal of Hepatology (2009)
Acute suppurative thyroiditis caused by Escherichia coli.
Authors: F Saksouk, I S Salti
Journal: BMJ (1977)

Of 474 women studied to identify epidemiological and clinical correlates of chlamydial infection of the cervix, Chlamydia trachomatis was isolated from 158 (33.3%) of all women, from 48.3% of those infected with Neisseria gonorrhoeae, from 43% of the sexual consorts of men with nongonococcal urethritis, and from 74% of those whose consorts were also infected with C trachomatis. C trachomatis was the sole pathogen found in 58 women. Age, marital state, occupation, past history of gonorrhoea, menstrual state, and symptoms had no predictive value. The isolation of C trachomatis was significantly associated with N gonorrhoeae, the use of oral contraceptives, cervical ectopy, cervicitis, and last sexual exposure more than one week previously. Except for three patients, none of the criteria alone or in combination was reliable enough to predict with acceptable accuracy that the 30 chlamydia-positive women among the 191 who were not infected with N gonorrhoeae and whose consorts were not known to have urethritis harboured chlamydia.
Orthopaedic surgeons and thromboprophylaxis
Authors: P. W Howard, R. B C Treacy, P. Grigoris
Journal: BMJ (1991)

300 ml (300 mg) per bottle.This may be a week's supply for a drug dependent adult, but 20-30 ml can be lethal to a small child.Methadone syrup tastes pleasant enough for children to consume 150-200 ml without complaint.Parents often delay bringing to hospital children who have taken methadone.Drug dependent adults who can tolerate large doses of the drug may assume that a child will "sleep it off," and parents may be deterred from taking a child to hospital because they know that their competence to look after the child will be questioned.We are not trying to imply that methadone users should not have the care of their small children, but some steps must be taken to protect these children.We strongly suggest that it should be a legal requirement that all methadone be prescribed in child resistant plastic bottles.Further, metha- done should be bitter to taste.Finally, very serious consideration should be given to limiting the quantity prescribed at any one time to methadone users who are responsible for small children.
Blood vessel formation in the tissue-engineered bone with the constitutively active form of HIF-1α mediated BMSCs
Authors: Duohong Zou, Zhiyuan Zhang, Jiacai He, Kai Zhang, Dongxia Ye, Wei Han, Jian Zhou, Yuanyin Wang, Quanli Li, Xin Liu, Xin Zhang, Shaoyi Wang, Jingzhou Hu, Chao Zhu, Wenjie Zhang, Yong zhou, Honghai Fu, Yuanliang Huang, Xinquan Jiang
Journal: Biomaterials (2011)
RELATION OF BLOOD ASCORBIC ACID CLEARANCE TO ARSENICAL INTOLERANCE IN SYPHILOTHERAPY
Authors: K. D. LAHIRI
Journal: British Journal of Dermatology (1943)

Journal Article RELATION OF BLOOD ASCORBIC ACID CLEARANCE TO ARSENICAL INTOLERANCE IN SYPHILOTHERAPY Get access K. D. LAHIRI, M.B., B.S. K. D. LAHIRI, M.B., B.S. Clinical Assistant, Skin and Venereal Department, Patna Medical College Hospital. Patna, India Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 55, Issue 6, 1 June 1943, Pages 158–159, https://doi.org/10.1111/j.1365-2133.1943.tb10769.x Published: 01 June 1943
From A Health Officer.
Authors: Joseph E. Barrett
Journal: JAMA (1895)

Wooster, Ohio, Oct. 1, 1895. <h3>To the Editor:</h3> —What seemed more than an herculean task a few months since—and it was even doubted whether it could be done—the editing of theJournal, is now grandly accomplished. TheJournalto-day is the best educator the profession in America has ever had. Glance over the articles it has contained for three or four months last past! Many of them are exhaustive on the subjects they discuss, and some bring to light new truths of great value to the profession. Accept my congratulations for your past success and my earnest wishes for your future usefulness. Fraternally,
LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival
Authors: Helmut Butzkueven, Jian-Guo Zhang, Merja Soilu-Hanninen, Hubertus Hochrein, Fiona Chionh, Kylie A. Shipham, Ben Emery, Ann M. Turnley, Steven Petratos, Matthias Ernst, Perry F. Bartlett, Trevor J. Kilpatrick
Journal: Nature Medicine (2002)
Kupffer cell activation by lipopolysaccharide in rats: Role for lipopolysaccharide binding protein and toll-like receptor 4
Authors: Grace L. Su, Richard D. Klein, Alireza Aminlari, Hong Y. Zhang, Lars Steinstraesser, William H. Alarcon, Daniel G. Remick, Stewart C. Wang
Journal: Hepatology (2000)

Lipopolysaccharide (LPS) binding protein (LBP) is a key serum factor that mediates LPS activation of mononuclear cells. In the presence of LBP, 1/1,000 the concentration of LPS is sufficient to activate peripheral blood monocytes. Previous studies with Kupffer cells have shown a variable effect of serum on LPS activation of these cells and led to the conclusion that, unlike extrahepatic mononuclear cells, Kupffer cells do not respond to LPS in an LBP-dependent fashion. Because there are multiple components in serum other than LBP that might affect LPS activation, these reports with serum are difficult to interpret. To investigate the specific role of LBP in LPS activation of Kupffer cells, we produced a functional recombinant rat LBP using a baculovirus expression system, which we used to selectively examine the role of LBP's on Kupffer-cell function. Isolated Kupffer cells exposed to increasing concentrations of LPS (0, 1, 10 ng/mL) showed a dose-dependent increase in TNF-α production, which was augmented and accelerated by the presence of LBP. The effects of LBP on Kupffer cell activation by LPS are dependent on a functional Toll-like receptor 4 (Tlr 4) because Kupffer cells from C3H/HeJ mice failed to respond to LPS in the presence of LBP. LBP plays an important role in mediating Kupffer cell activation by LPS, and these effects are dependent on the presence of functioning Tlr 4.