tbuckley/cabot-search huggingface dataset:
Porphyria Cutanea Tarda in Two Patients Treated with Hemodialysis for Chronic Renal Failure
Authors: Maureen B. Poh-Fitzpatrick, Neil Bellet, Vincent A. DeLeo, Marc E. Grossman, David R. Bickers
Journal: New England Journal of Medicine (1978)

THERE have been several reports of a cutaneous blistering eruption occurring in patients with chronic renal failure undergoing hemodialysis1 2 3 4 5 that clinically and histopathologically resembles that of porphyria cutanea tarda. Examinations of plasma, urine or feces for elevated porphyrins were negative in these reports except for one case of elevated uroporphyrin in urine,2 and the condition has been called pseudoporphyria or chronic bullous dermatosis of hemodialysis.In this report we describe a patient with subepidermal bullae occurring after hemodialysis who had abnormally large quantities of porphyrins in plasma, feces, urine and blister fluid. Chromatographic and fluorescence spectral data indicated a porphyrin . . .
Cataract Surgery and Motor Vehicle Crashes—Proceed With Caution
Authors: Barbara E. K. Klein
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE ORGANIZATION OF THE UNIVERSITY MEDICAL SCHOOL
Authors: ARTHUR DEAN BEVAN
Journal: JAMA (1926)

For twenty-two years I have been chairman of the Council on Medical Education of the American Medical Association. During this period I have had the opportunity of studying the organization of our American medical schools. During this period most of our medical schools which survived the revolution which the American Medical Association brought about have become the medical departments of universities, and a number of universities have created new medical departments.  It is unnecessary for me here to review the great changes that have taken place. These changes have amounted to a complete reorganization. I desire from my study of this subject to present my conception of how a university should organize and conduct a school of medicine. The task of developing a modern medical school has become one of the greatest, one of the most important functions of a university. It is also one of the most difficult and
Beta‐blocker therapy in advanced heart failure: clinical characteristics and long‐term outcomes
Authors: Christopher M. O'Connor, Wendy A. Gattis, Faiez Zannad, Steven E. McNulty, Mihai Gheorghiade, Kirkwood F. Adams, Robert M. Califf, William J. McKenna, Jordi Soler‐Soler, Karl Swedberg
Journal: European Journal of Heart Failure (1999)
Does Comparative-Effectiveness Research Threaten Personalized Medicine?
Authors: Alan M. Garber, Sean R. Tunis
Journal: New England Journal of Medicine (2009)

The American Reinvestment and Recovery Act gives comparative-effectiveness research (CER) a large boost in funding over the next 2 years. Despite a consensus that better information about the relative effectiveness of different medical interventions is needed to improve the quality and value of care, some view CER with skepticism. Recently, the Partnership to Improve Patient Care, a coalition of 36 industry, patient-advocacy, and clinician organizations, raised concerns that CER will not take adequate account of individual patient differences and may impede the development and adoption of improvements in medical care and “stymie progress in personalized medicine.”1 The controversy stems in . . .
Do you know your chocolates? Recognition survey among medical staff of various grades
Authors: F. Cooke, R. Morse
Journal: BMJ (1997)

a significantly lower number of term deliveries as the number of preterm deliveries was as expected (O/E = 1.01; 0.84 to 1.21).As shown in the table, this led to an overall 44% increased risk of a preterm compared to term delivery on Christmas Eve when comparing with other days of the yearThe frequency of caesarean sections during the three days before Christmas Eve was as expected (OR = 0.99, 0.91 to 1.09), but it was significantly lower than expected on Christmas Eve (OR = 0.72, 0.60 to 0.87) and on the 3 following days (OR = 0.76, 0.68 to 0.84).Women under 20 years of age had close to the expected proportion of births at Christmas (0.25%), but this proportion fell to 0.22% in those aged 20-24 and was between 0.18% and 0.19% in older age groups (P for trend < 0.001).The number of liveborn children was inversely associated with risk of a Christmas birth; this was explained primarily by a drop in risk between women without a previous birth and women with a history of one or more previous births (table ).This association remained significant after age was adjusted for (P for trend < 0.001).Births at Christmas and at other times did not differ with respect to the sex of the child and the proportion of multiple births.
Morphological Analysis and Lentiviral Transduction of Fetal Monkey Bone Marrow-Derived Mesenchymal Stem Cells
Authors: Chang I Lee, Donald B Kohn, Jason E Ekert, Alice F Tarantal
Journal: Molecular Therapy (2003)

We explored the transduction kinetics of HIV-1-derived lentiviral vectors containing the CMV, EF1α, or PGK promoter expressing EGFP in fetal rhesus monkey bone marrow-derived mesenchymal stem cells (rhMSC). Studies included the effects of transduction (MOI 0–100) on growth, cell cycle, and differentiation toward an osteogenic lineage. Flow cytometric analysis indicated an approximate 8- to 10-fold greater quantity of EGFP-expressing rhMSC when cells were transduced with the CMV or EF1α promoter compared to PGK, although quantitative PCR revealed no differences at the DNA level. The CMV promoter initially expressed 10- to 100-fold higher levels of EGFP compared to EF1α or PGK, respectively, at increasing MOI, although a significant decline in transgene expression was observed posttransduction and with advancing passage (P < 0.01), whereas a significant increase in the level of expression was observed over time with the EF1α promoter. At an MOI of 100, a transient arrest at the S phase of the cell cycle was observed for both vector constructs. Transduced rhMSC differentiated toward an osteogenic lineage comparable to untransduced rhMSC and showed equivalent levels of alkaline phosphatase activity. These findings suggest that the SIN HIV-1-derived lentiviral vectors used in these studies can efficiently transduce rhMSC in vitro (CMV > EF1α > PGK) without inhibiting differentiation potential, although the cell cycle was transiently altered at high MOI
Death risk other than from suicide is raised in self harm
Authors: C. Stark
Journal: BMJ (2003)

EDITOR—Jenkins et al report on continuing suicide risk after deliberate self harm.1 They use their findings to argue that clinicians should pay close attention to continuing risk of suicide in people with a history of deliberate self harm. Their findings, in a cohort from the late 1970s, are similar to findings from a 1981 Scottish discharge cohort.2

Using the Scottish linked dataset we followed up a cohort of …
Role of ATP sensitive potassium channels in long term adaptation to metabolic stress
Authors: J. S Cameron, R. Baghdady
Journal: Cardiovascular Research (1994)

Journal Article Role of ATP sensitive potassium channels in long term adaptation to metabolic stress Get access John S Cameron, John S Cameron Department of Biological Sciences, Wellesley College, Wellesley, MA 02181, USA: J S Cameron, R Baghdady. Search for other works by this author on: Oxford Academic PubMed Google Scholar Rose Baghdady Rose Baghdady Department of Biological Sciences, Wellesley College, Wellesley, MA 02181, USA: J S Cameron, R Baghdady. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 6, June 1994, Pages 788–796, https://doi.org/10.1093/cvr/28.6.788 Published: 01 June 1994 Article history Received: 08 December 1993 Accepted: 28 February 1994 Published: 01 June 1994
537. Transcriptionally Targeting the Survivin Promoter to Human Gliomas
Authors: Zeng B. Zhu, Winan J. Houdt, Yosef S. Haviv, Baogen Lu, Minghui Wang, Angel A. Rivera, Ilya V. Ulasov, Maciej S. Lesniak, Gene P. Siegal, Clemens M.F. Dirven, David T. Curiel
Journal: Molecular Therapy (2005)

Survivin, a novel member of the IAP (inhibitor of apoptosis) protein family, is associated with malignant transformation and is overexpressed in human brain cancers. On this basis, we hypothesized that the human survivin promoter may be an excellent candidate for glioma gene therapy by transcriptional targeting. To that end, we compared three recombinant adenoviral vectors (reAds), reAdGL3BCox-2, reAdGL3BMidkine, and reAdGL3BSurvivin, in which the reporter gene luciferase is driven by the Cox-2, Midkine, or surivin promoter, respectively, in glioma cell lines and primary glioma cells. The data showed the survivin promoter exhibited the highest activity among the three reAd vectors in both established and primary glioma cells. We also compared the survivin promoter activity between in D65 glioma tumor cells and in normal non-transformed astrocytes. The results indicate there is 6-12 fold higher activity in tumor cells than in the astrocytes. Also, the survivin promoter is down regulated in human brain tissue compared to the cytomegalovirus promoter. Next, the conditionally replicating adenoviral vector (CRAd), CRAd-Survivin-RGD, in which the Ad E1 gene is driven by the survivin promoter, and the Ad infectivity is enhanced by capsid modification with RGD, was seen to efficiently kill the multiple established glioma tumor cells (oncolysis). These CRAd agents driven by the survivin promoter were further shown to efficiently replicate in both the glioma cells (D65) and in U118MG xenografts both in vitro and in vivo. Also we observed the anti-tumor effects of the CRAd agents in an animal model. The tumor growth was inhibited more than 60% by i.t. injection of CRAd-Survivin agents. In conclusion, the survivin promoter is a promising tumor-specific promoter for transcriptional targeting based on its activation in glioma cells, efficient reporter gene expression, adenoviral replication in gliomas and repression in normal cells. This promoter has a |[ldquo]|tumor on|[rdquo]| and |[ldquo]|normal tissue off|[rdquo]| profile, an important parameter for cancer gene therapy. To that end, therapeutic vectors based on this approach may translate into treatment of human gliomas in the clinic.
Treatment of exercise‐induced asthma, respiratory and allergic disorders in sports and the relationship to doping: Part II of the report from the Joint Task Force of European Respiratory Society (ERS) and European Academy of Allergy and Clinical Immunology (EAACI) in cooperation with GA<sup>2</sup>LEN*
Authors: K. H. Carlsen, S. D. Anderson, L. Bjermer, S. Bonini, V. Brusasco, W. Canonica, J. Cummiskey, L. Delgado, S. R. Del Giacco, F. Drobnic, T. Haahtela, K. Larsson, P. Palange, T. Popov, P. Van Cauwenberge
Journal: Allergy (2008)

Aim: The aims of part II is to review the current recommended treatment of exercise‐induced asthma (EIA), respiratory and allergic disorders in sports, to review the evidence on possible improvement of performance in sports by asthma drugs and to make recommendations for their treatment. Methods: The literature cited with respect to the treatment of exercise induced asthma in athletes (and in asthma patients) is mainly based upon the systematic review given by Larsson et al. (Larsson K, Carlsen KH, Bonini S. Anti‐asthmatic drugs: treatment of athletes and exercise‐induced bronchoconstriction. In: Carlsen KH, Delgado L, Del Giacco S, editors. Diagnosis, prevention and treatment of exercise‐related asthma, respiratory and allergic disorders in sports. Sheffield, UK: European Respiratory Journals Ltd, 2005:73–88) during the work of the Task Force. To assess the evidence of the literature regarding use of β 2 ‐agonists related to athletic performance, the Task Force searched Medline for relevant papers up to November 2006 using the present search words: asthma, bronchial responsiveness, exercise‐induced bronchoconstriction, athletes, sports, performance and β 2 ‐agonists. Evidence level and grades of recommendation were assessed according to Sign criteria. Results: Treatment recommendations for EIA and bronchial hyper‐responsiveness in athletes are set forth with special reference to controller and reliever medications. Evidence for lack of improvement of exercise performance by inhaled β 2 ‐agonists in healthy athletes serves as a basis for permitting their use. There is a lack of evidence of treatment effects of asthma drugs on EIA and bronchial hyper‐responsiveness in athletes whereas extensive documentation exists in treatment of EIA in patients with asthma. The documentation on lack of improvement on performance by common asthma drugs as inhaled β 2 ‐agonists with relationship to sports in healthy individuals is of high evidence, level (1+). Conclusions: Exercise induced asthma should be treated in athletes along same principles as in ordinary asthma patients with relevance to controller and reliever treatment after careful diagnosis. There is very high level of evidence for the lack of improvement in athletic performance by inhaled β2‐agonists.
Antibody Response to Pneumococcal Polysaccharides in Insulin-dependent Diabetes Mellitus
Authors: Michael M Lederman, Harvey M Rodman, Bernice Z Schacter, Paul K Jones, Gerald Schiffman
Journal: Diabetes Care (1982)

Twenty-one insulin-dependent diabetics and 11 healthy control children were immunized with polyvalent pneumococcal polysaccharide vaccine. Serum antibody to pneumococcal polysaccharides was measured by radioimmunoassay before and after immunization. Although there were some differences in type-specific antibody concentrations between diabetic and control subjects, the overall antibody concentrations preimmunization, 3–4 wk postimmunization, and 6–7 wk postimmunization were similar in both populations. In both groups antibody response to immunization correlated strongly with preimmunization antibody concentration. Among the diabetic subjects there was no correlation between antibody responses and duration of disease, insulin dose, or concentration of glycosylated hemoglobin. Insulin-dependent diabetic subjects have a serum antibody response to pneumococcal polysaccharides equivalent to that of controls, and in both populations the magnitude of the antibody response correlates with preimmunization antibody levels.
Abstract 3052: Relationship Between Subclinical Systolic Dysfunction and Intraventricular Asynchrony in Patients With Heart Failure and Preserved Ejection Fraction
Authors: Erberto Carluccio, Paolo Biagioli, Gianfranco Alunni, Adriano Murrone, Valeria Leonelli, Cinzia Zuchi, Paola Pantano, Giuseppe Ambrosio
Journal: Circulation (2009)

Background: Patients with Heart Failure and preserved Ejection Fraction (HFpEF) often show subtle abnormalities of left ventricular (LV) contractility at analysis of Tissue Doppler (TDI) velocities...
IMPORTANCE TO THE PRACTICING OPHTHALMOLOGIST OF CONTRIBUTING TO LITERATURE
Authors: ARNOLD KNAPP
Journal: JAMA (1926)

To make a satisfactory contribution to literature, it is necessary first of all to select a subject, and then to be familiar with the literature pertinent to that subject. Some knowledge of literature is in fact a necessary qualification, and this is not as difficult as it may seem, for our fundamental knowledge of any subject can be learned from textbooks. They contain the accumulated knowledge of previous observers which time has shown to be correct. Our knowledge grows through the addition of new observations, which in turn must be substantiated before they are adopted and admitted to the textbook. During this probationary period, which is necessarily often quite long, the observations must be made available by appearing in the current journals. A knowledge of these observations is necessary to keep abreast of one's subject. Their study creates new interest in our work, which from repetition frequently becomes monotonous, and
A 5 years parallel observation study of the use of sequential compression biomechanical device (SCBD) in critical limb ischaemia (CLI) patients with un-reconstructable peripheral vascular disease (PVD) vs primary amputation in a tertiary referral vascular centre
Authors: N. Hamada, E. Soylu, A. Fahy, W. Tawfick, S. Sultan
Journal: International Journal of Surgery (2011)
A Framework for the Next Generation of Risk Science
Authors: Daniel Krewski, Margit Westphal, Melvin E. Andersen, Gregory M. Paoli, Weihsueh A. Chiu, Mustafa Al-Zoughool, Maxine C. Croteau, Lyle D. Burgoon, Ila Cote
Journal: Environmental Health Perspectives (2014)

Objectives: In 2011, the U.S. Environmental Protection Agency initiated the NexGen project to develop a new paradigm for the next generation of risk science.Methods: The NexGen framework was built on three cornerstones: the availability of new data on toxicity pathways made possible by fundamental advances in basic biology and toxicological science, the incorporation of a population health perspective that recognizes that most adverse health outcomes involve multiple determinants, and a renewed focus on new risk assessment methodologies designed to better inform risk management decision making.Results: The NexGen framework has three phases. Phase I (objectives) focuses on problem formulation and scoping, taking into account the risk context and the range of available risk management decision-making options. Phase II (risk assessment) seeks to identify critical toxicity pathway perturbations using new toxicity testing tools and technologies, and to better characterize risks and uncertainties using advanced risk assessment methodologies. Phase III (risk management) involves the development of evidence-based population health risk management strategies of a regulatory, economic, advisory, community-based, or technological nature, using sound principles of risk management decision making.Conclusions: Analysis of a series of case study prototypes indicated that many aspects of the NexGen framework are already beginning to be adopted in practice.Citation: Krewski D, Westphal M, Andersen ME, Paoli GM, Chiu WA, Al-Zoughool M, Croteau MC, Burgoon LD, Cote I. 2014. A framework for the next generation of risk science. Environ Health Perspect 122:796–805; http://dx.doi.org/10.1289/ehp.1307260
Epistemology, two types of functionalism, and first-person authority
Authors: Alvin I. Goldman
Journal: Behavioral and Brain Sciences (1995)

Abstract My target article did not attribute a pervasive ontological significance to phenomenology, so it escapes Bogdan's “epistemological illusion.” Pust correctly pinpoints an ambiguity between contentinclusive and content-exclusive forms of folk functionalism. Contrary to Fodor, however, only the former is plausible, and hence my third argument against functionalism remains a threat. Van Brakel's charity approach to first-person authority cannot deal with authority vis-a-vis sensations, and it has some extremely odd consequences.
The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration
Authors: Markéta Kaucká, Karla Plevová, Šárka Pavlová, Pavlína Janovská, Archana Mishra, Jan Verner, Jiřina Procházková, Pavel Krejčí, Jana Kotašková, Petra Ovesná, Boris Tichý, Yvona Brychtová, Michael Doubek, Alois Kozubík, Jiří Mayer, Šárka Pospíšilová, Vítězslav Bryja
Journal: Cancer Research (2013)

Abstract The planar cell polarity (PCP) pathway is a conserved pathway that regulates cell migration and polarity in various contexts. Here we show that key PCP pathway components such as Vangl2, Celsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3, and casein kinase 1 (CK1)-ϵ are upregulated in B lymphocytes of patients with chronic lymphocytic leukemia (CLL). Elevated levels of PCP proteins accumulate in advanced stages of the disease. Here, we show that PCP pathway is required for the migration and transendothelial invasion of CLL cells and that patients with high expression of PCP genes, FZD3, FZD7, and PRICKLE1, have a less favorable clinical prognosis. Our findings establish that the PCP pathway acts as an important regulator of CLL cell migration and invasion. PCP proteins represent an important class of molecules regulating pathogenic interaction of CLL cells with their microenvironment. Cancer Res; 73(5); 1491–501. ©2012 AACR.
Postdiarrheal Shiga Toxin–Mediated Hemolytic Uremic Syndrome
Authors: Richard L. Siegler
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal