tbuckley/cabot-search huggingface dataset:
The grateful patients of Arles
Authors: A L Wyman
Journal: BMJ (1995)

The papers seemed to be full of the misdemeanours of doctors. A diagnosis had been missed here. An operation had gone wrong there. Some unfortunate old person had lain for hours on a trolley, waiting for admission to a ward. Another had been transferred to a hospital remote from home because no nearer bed was available. On television an angry woman raged against the arrogance of surgeons. Patients or their relatives …
Generation of superoxide anion and chemiluminescence by human monocytes during phagocytosis and on contact with surface-bound immunoglobulin G.
Authors: R B Johnston, J E Lehmeyer, L A Guthrie
Journal: The Journal of Experimental Medicine (1976)

Extent of O-2-release and chemiluminescence, attributed to singlet oxygen, has been compared in human monocytes and neutrophils during phagocytosis, stimulation by the surface-active agent phorbol myristate acetate, or contact with aggregated IgG in a model of immune complex disease. Monocytes generated O-2-and chemiluminescence with each of the three stimuli, although values were significantly less than those of neutrophils from the same individuals. Lymphocytes had no significant activity in either assay with any stimulus. Oxygen metabolites released from mononuclear phagocytes are highly reactive and could play a part in both the beneficial and detrimental aspects of chronic inflammation.
FRACTURED BASE, WITH DEAFNESS, TINNITUS, VERTIGO, EXOPTHALMUS, FACIAL PARALYSIS, MASTOIDITIS.
Authors: J. A. STUCKY
Journal: JAMA (1899)

The following case is presented on account of its peculiar interest from an etiologic standpoint, as well as its uniqueness and rarity. F. T., a jockey, aged 21, on March 15, 1899, was exercising a horse under a shed when the animal reared, throwing the rider against the rafters, and striking his head with such violence that he was thrown to the ground. He was unconscious for only a short time. Dr. J. M. Allen saw him shortly after the accident, and reports that there was a large contusion of the scalp covering the top of the head, and this was rapidly followed by edema extending down to both ears, more marked on the right side. He complained of great noise in his right ear, and deafness, and was very restless. There was no hemorrhage from the nose or ear, though the patient says he "spit up a few mouthfuls
Is the Risk of Concomitant Invasive Esophageal Cancer in High-Grade Dysplasia in Barrett’s Esophagus Overestimated?
Authors: Vani J.A. Konda, Andrew S. Ross, Mark K. Ferguson, John A. Hart, Shang Lin, Keith Naylor, Amy Noffsinger, Mitchell C. Posner, Charles Dye, Barbara Cislo, Lynne Stearns, Irving Waxman
Journal: Clinical Gastroenterology and Hepatology (2007)
National Patterns of Care and Outcomes After Combined Modality Therapy for Stage IIIA Non–Small-Cell Lung Cancer
Authors: Aalok P. Patel, Traves D. Crabtree, Jennifer M. Bell, Tracey J. Guthrie, Clifford G. Robinson, Daniel Morgensztern, Graham A. Colditz, Daniel Kreisel, A. Sasha Krupnick, Jeffrey D. Bradley, G. Alexander Patterson, Bryan F. Meyers, Varun Puri
Journal: Journal of Thoracic Oncology (2014)
Stockholm Speakers on Adolescents and AIDS: 'Catch Them Before They Catch It'
Authors: Marsha F. Goldsmith
Journal: JAMA (1988)

THE NEXT GENERATION of persons with acquired immunodeficiency syndrome (AIDS) is getting sick now. The number of adolescents infected with human immunodeficiency virus (HIV) is rising slowly but steadily around the world, according to reports presented in Stockholm at the Fourth International Conference on AIDS. In contrast to children born to infected mothers or those who have acquired the disease from contaminated blood products, today's teenagers who will be tomorrow's AIDS statistics could avoid catching the virus. In contrast to the many homosexual men (and some intravenous [IV] drug users) who have reportedly ceased their high-risk behavior in response to the AIDS threat, self-perceived "invulnerable" teenagers continue living dangerously. Whether the problem is lack of information, lack of belief, or something else is debated. But eight years into the epidemic, adults who care are arming themselves with facts and figures and refining educational strategies they hope will help adolescents stay
Correlations Between Mood, Urinary Electrolytes, and Weight During the Menstrual Cycle.
Authors: David S. Janowsky
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Correlations Between Mood, Urinary Electrolytes, and Weight During the Menstrual Cycle.David S. Janowsky, M.D., Steven Berens, M.D., John M. Davis, M.D.David S. Janowsky, M.D.Search for more papers by this author, Steven Berens, M.D.Search for more papers by this author, John M. Davis, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-858_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA correlation between premenstrual-menstrual mood changes, weight changes, and alterations in the aldosterone-dependent urinary potassium-to-sodium ratio during the menstrual cycle was studied. Eleven female college-age volunteers were studied on a metabolic ward for a total of 410 days during which time 14 menses occurred. Daily negative-affect self-ratings, preprandial postvoiding morning weights, and 24-hour urinary collections were obtained and analyzed for potassium-to-sodium ratios. All subjects were placed on a constant caloric intake and a 100 mEq/day sodium chloride diet and housed on a metabolic ward. Data analysis showed a significant positive correlation between the subject groups' negative affect for a given... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: David S. Janowsky, M.D.; Steven Berens, M.D.; John M. Davis, M.D.Affiliations: Nashville, Tenn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 858-858KeywordsDietMenstrual cycleSaltsSodium chloride ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
Abstract LB-105: Gli-IKBKE interactions in pancreatic tumorigenesis
Authors: Mihir Rajurkar, Wilfredo E. De Jesus-Monge, David Driscoll, Jennifer L. Cotton, Brian C. Lewis, Junhao Mao
Journal: Cancer Research (2012)

Abstract Oncogenic mutations in KRAS are detected in a majority of human pancreatic malignancies, and are considered an initiating event in pancreatic ductal adenocarcinoma (PDAC). The downstream mechanisms through which KRAS drives tumorigenesis remain elusive. While recent in vitro studies have suggested that Gli proteins, the transcriptional effectors of Hedgehog signaling, may mediate KRAS oncogenic activity in PDAC cell lines, a requirement for Gli activation in pancreatic tumorigenesis has not been demonstrated in vivo. Here, we use genetically modified mouse models, and human PDAC cell lines to establish a requirement for Gli activation in KRAS initiation of pancreatic tumorigenesis, and identify IKBKE as a novel oncogenic target gene of Gli in PDAC. We show for the first time that inhibition of Gli transcription in the pancreatic epithelium suppressed the ability of activated KRAS to initiate tumorigenesis in vivo. Also, we find that expression of Gli1 along with oncogenic KRAS led to a dramatic acceleration in the formation of pancreatic intraepithelial neoplasia (PanIN) lesions, and increased mortality. Importantly, we identify IKBKE as a novel transcriptional target of Gli in PDAC cells, and also in the pancreatic epithelium in vivo. We also demonstrate that IKBKE is required for the survival and tumorigenicity of PDAC cells, thus implicating IKBKE as a novel pancreatic cancer oncogene. We have found that IKBKE activates the NF-kB pathway, and also activates Akt by phosphorylation in PDAC cells as part of its tumorigenic activity. Our studies demonstrate for the first time a requirement for Gli transcriptional activity in KRAS induced pancreatic tumorigenesis in vivo, and establish IKBKE as a novel Gli target and pancreatic cancer oncogene. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-105. doi:1538-7445.AM2012-LB-105
Insights into intimacy
Authors: Richard Smith
Journal: BMJ (2004)

lifestyle have no effect on the control of blood pressure.Little and colleagues (p 1054) randomised 296 patients with a single high reading to combinations of simple interventions-an information booklet, lifestyle prompts, and advice to use a low sodium-high potassium salt-or standard care.The interventions did not modify blood pressure but they did prompt patients to change their diet, which may be important in the overall management of blood pressure.
Superficial Gangrene in Adolescent Diabetes
Authors: H. Whittaker
Journal: BMJ (1944)

Lymphocytes, mainly of the small variety, made up the remainder.A hyperchromic type of anaemia affected the red blood cells, the colour index being 1.4.Haematologically, therefore, the signs were those of monocytic leukaemia.Refer- ence to the literature, however, indicated that these facts alone were not conclusive' evidence in favour of such a diagnosis.
Control of Infection in Recent Wounds
Authors: F. H. Bentley, S. Thomson
Journal: BMJ (1945)

Penicillin Control Team, Central Mediterranean Force) ' Infected."-Theterm " infected " indicated only the presence of pyogenic cocci in a wound-Staph.pyogenes aureus or Str.pyogenes." Septic."-Thosedirty wounds that were infected with pyogenic cocci were called " septic."About half the dirty wounds came into this category.4396
Abstract B16: Extracellular S100A4 as an inducer of a cytokine network that mediates tumor-stroma crosstalk: Potential implications for metastases
Authors: Ingrid J. Bettum, Kotryna Vasiliauskaite, Solveig J. Pettersen, Gunhild M. Malandsmo, Lina Prasmickaite
Journal: Cancer Research (2013)

Abstract Among soluble factors that appear to be of high importance for metastasis progression are chemokines from the S100 family. One such factor is S100A4, a small calcium binding protein linked to metastasis and poor prognosis in several cancer types. The protein is expressed in and secreted from not only tumor cells, but also various stroma cells, suggesting that S100A4 might be an important factor in the tumor microenvironment. Recently we have revealed that in vivo S100A4-positive stroma cells are tightly associated with the metastatic nodules in the brain and lungs, suggesting the role of S100A4 in facilitating metastatic growth in these microenvironments. How S100A4 executes its metastasis-promoting functions is however not fully elucidated. Here we hypothesize that the extracellular S100A4 can trigger a cytokine network that mediates the tumor-stroma crosstalk and thereby facilitates metastases progression in malignant melanoma. We have shown that extracellular S100A4 stimulates melanoma cells to secrete various cytokines and growth factors, including IL-8, IL-6, CXCL2, sICAM-1 and VEGF, molecules playing a role in cancer progression and angiogenesis in particular. Since cytokines can act in a paracrine manner, they can mediate interactions between tumor cells and stroma cells. Thus, we have shown that conditioned medium from melanoma cells treated with extracellular S100A4 modulates the angiogenic functions of endothelial cells making them more migratory and more proned to make vascular-like networks in vitro. Among factors induced by S100A4 were also pro-inflammatory cytokines associated with macrophage recruitment and/or activation. Currently we are investigating whether the S100A4-triggered cytokines modulate the properties of macrophages making them support tumor cells. Altogether, our results indicate a potential role of S100A4 in stimulating tumor-stoma crosstalk which might mimic the formation of a metastatic niche-like milieu facilitating metastases. Citation Format: Ingrid J. Bettum, Kotryna Vasiliauskaite, Solveig J. Pettersen, Gunhild M. Malandsmo, Lina Prasmickaite. Extracellular S100A4 as an inducer of a cytokine network that mediates tumor-stroma crosstalk: Potential implications for metastases. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr B16.
Together in the Dark: Mysteries of Healing
Authors: Jon F. Watchko
Journal: JAMA (1989)

<i>Together in the Dark</i>, a collection of sketches, stories, and essays by Robert H. Colfelt, MD, constitutes a compelling exploration of the physician-patient relationship. Everyday encounters with his patients and colleagues form the foundation of the portrait of medicine and healing Dr Colfelt creates. Little is left unnoticed by this talented, keen, often wry observer. The resulting work is original and powerful—a vivid and thoughtful evocation of the caring spirit. Dr Colfelt, a neurologist and clinical associate professor at the University of Washington, has previously shared many of his essays in<i>The Bulletin</i>of the King County Medical Society—a publication he has edited since 1978. In Seattle, Dr Colfelt's writings have been received with great interest and enthusiasm. Now, thanks to the urging of friends and associates, his essays have been compiled for a larger reading audience. It is rare to read a book written with such sensitivity and clarity.
Influenza Vaccine First to Reach Immunization Goal
Authors: Charles Marwick
Journal: JAMA (1995)

IMMUNIZATION against influenza may have reached the goal set by the Public Health Service for the year 2000, making flu vaccine the first to reach so many of its target recipients. "Preliminary data for 1994 show that we have probably immunized 60% of those aged 65 years and over," says Raymond Strikas, MD, of the National Immunization Program of the Centers for Disease Control and Prevention (CDC), Atlanta, Ga. "It's not completely clear that we have actually reached that goal, but certainly we are closer than we have been." See also p 769. Strikas summarized recent progress in influenza immunization at a meeting of the CDC's Advisory Committee on Immunization Practices. "The last year for which we have some reasonably complete information was 1993," he said. "In that year, the number of doses of influenza vaccine used was in the range of 40 to 41 million." However, he noted, the
Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia
Authors: Elli Papaemmanuil, Fay J Hosking, Jayaram Vijayakrishnan, Amy Price, Bianca Olver, Eammon Sheridan, Sally E Kinsey, Tracy Lightfoot, Eve Roman, Julie A E Irving, James M Allan, Ian P Tomlinson, Malcolm Taylor, Mel Greaves, Richard S Houlston
Journal: Nature Genetics (2009)
Thrombocytopenic c-mpl−/− mice can produce a normal level of platelets after administration of 5-fluorouracil: the effect of age on the response
Authors: Jack Levin, Laurence Cocault, Corinne Demerens, Cécile Challier, Michèle Pauchard, Jacques Caen, Michèle Souyri
Journal: Blood (2001)
False Elevations of Serum Glutamic-Oxalacetic Transaminase Due to Para-Aminosalicylic Acid
Authors: KEVIN P. GLYNN
Journal: Annals of Internal Medicine (1970)

Para-aminosalicylic acid (PAS) in serum has been shown by in vivo and in vitro studies to induce false elevations in serum glutamic-oxalacetic transaminase (SGOT) level as determined by the colorimetric method commonly used in automated analyzers. This does not appear to reflect any hepatic injury, and no changes have been found in SGOT levels determined by the specific reduced nicotinamide adenine dinucleotide (NADH)-linked method of Karmen, or found in serum glutamic-pyruvic transaminase (SGPT), or in serum lactic acid dehydrogenase (LDH) levels. As the use of multichannel analyzers becomes more widespread more reactions of this type will be observed in patients receiving other drugs.
In adults with t(8;21)AML, posttransplant RUNX1/RUNX1T1-based MRD monitoring, rather than c-KIT mutations, allows further risk stratification
Authors: Yu Wang, De-Pei Wu, Qi-Fa Liu, Ya-Zhen Qin, Jing-Bo Wang, Lan-Ping Xu, Yan-Rong Liu, Hong-Hu Zhu, Jia Chen, Min Dai, Xiao-Jun Huang
Journal: Blood (2014)
Rules of Hepatobiliary Imaging Using Tc-99m EHIDA
Authors: SELIM M. ANSARI, ROSTAMUDDIN AHMED, None ROKONUDDIN
Journal: Clinical Nuclear Medicine (1989)

Tc-99m labelled 2,6-diethylphenylcarbamoylmethyliminodiacetic acid (EHIDA) is a non-toxic radiopharmaceutical that was found to undergo rapid biliary excretion in a normal human, with accumulation of radioactivity in the gall bladder and intestine. Images in normal subjects and nonjaundiced patients showed rapid concentration of tracer by the liver and the passage of the same into the intestine within 15 to 40 minutes, with or without visualization of the gall bladder. In the jaundiced patient, the tracer blood clearance was delayed and urinary excretion was increased. Tc-99m EHIDA has been extensively investigated in 1634 patients to evaluate its performance in the diagnosis of hepatobiliary disorders.
A worrying statistic
Authors: G Phillips
Journal: BMJ (1996)

It had been a busy but gratifying year. In accordance with the desires of the new NHS trust we had laboured long and hard. Our acute geriatric unit of 96 beds had admitted a record 3500 patients that year and standards had been maintained even though it had been necessary to put some patients in surgical wards during the winter. We eagerly awaited the official analysis of performance in the hope of securing increased funding based on the improvement in performance.

The …
Medical Day Care Center: Solution to "Unnecessary" Hospital Admission
Authors: Jonas Brachfeld
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Amid the concern about high medical costs and "poor delivery" of medical care, the problem of unnecessary hospital admission is often raised. This category comprises a group of patients who are in the hospital primarily for study and clinical observation. A number of remedies have been proposed to avoid this waste, but none seem to have been effective. For example, Blue Cross regulations eliminating "admission for diagnostic studies only" have had as sole result the development of a sense of "chartmanship" among physicians, who now handle the chart with emphasis on treatment, although the main objectives might be diagnosis. Outpatient coverage has been made available for laboratory and x-ray film studies, but Blue Cross surveys have shown that this has not necessarily decreased the number of hospital admissions. A wide variety of professionals, such as economists, administrators, legislators, and others, have offered solutions and some of these,
MID REGIONAL PRO-ADRENOMEDULLIN (MR-PROADM) IS SUPERIOR TO BNP (B-TYPE NATRIURETIC PEPTIDE) IN PREDICTING MORTALITY IN STABLE OUTPATIENTS WITH STAGE A HEART FAILURE FOLLOWED FOR 6 YEARS
Authors: Pam Taub, Yang Xue, Navaid Iqbal, Arrash Fard, Paul Clopton, Alan Maisel
Journal: Journal of the American College of Cardiology (2011)
Improved Protection of the Hypertrophied Left Ventricle by Histidine-Containing Cardioplegia
Authors: Koh Takeuchi, Percival Buenaventura, Hung Cao-Danh, Paul Glynn, Elena Simplaceanu, Francis X. McGowan, Pedro J. del Nido
Journal: Circulation (1995)

Background Myocardial hypertrophy has been shown to lead to increased susceptibility to ischemia with accelerated loss of high-energy nucleotides, greater accumulation of H + and lactate, and earlier onset of contracture. Methods and Results To determine whether promoting anaerobic glycolysis during ischemia by buffering H + results in improved preservation of the hypertrophied heart, we studied the effect of a histidine-containing solution (HBS) on recovery of contractile function and energetic state. Hypertrophied rabbit hearts (aortic banding at 10 days) were subjected to 40 minutes of 37°C ischemia and reperfusion in an isolated Langendorff model. This group was compared with groups receiving St Thomas solution and high-potassium Krebs buffer solution (KCl). Although both phosphocreatine (PCr) and ATP were lower in hypertrophied hearts by end-ischemia compared with nonhypertrophied age-matched controls, there was significantly higher PCr, ATP, and intracellular pH in the HBS group compared with the St Thomas and KCl groups. Recovery of left ventricular developed pressure was best in the HBS group (91% of preischemic values) as was end-diastolic pressure after 30 minutes of reperfusion. Lactate production was also significantly greater in the HBS group, suggesting augmentation of anaerobic glycolysis. Conclusions We concluded that administration of histidine-containing cardioplegia promotes anaerobic glycolysis and improves recovery of high-energy phosphates and contractile function in hypertrophied myocardium.
Welcome to the Physicians of Southeast Asia
Authors: George D. Lundberg
Journal: JAMA (1985)

In January 1985 we will begin monthly publication of the next edition of the<i>Journal of the American Medical Association</i>in Hong Kong. The Southeast Asian edition of<i>JAMA</i>(<i>SEA-JAMA</i>) will be distributed in nine countries: Burma, Hong Kong, Indonesia, Malaysia, the Philippines, Singapore, Sri Lanka, Taiwan, and Thailand. This edition is added to those already serving the People's Republic of China, Japan, France, Switzerland, West Germany, Belgium, and Italy.<sup>1</sup>We are pleased with all of these efforts, but we are particularly excited about<i>SEAJAMA</i>because it is new and different in so many ways. It will be our first major entry into what is known as the "third world." Of course, our regular English-language version circulates in scores of third world countries, but the number of subscriptions is small and includes mostly universities, hospitals, companies, and government and private institutions. SEAJAMA, in contrast, will serve primarily direct
Does Glycemic Control Offer Similar Benefits Among Patients With Diabetes in Different Regions of the World?
Authors: Mark Woodward, Anushka Patel, Sophia Zoungas, Lisheng Liu, Changyu Pan, Neil Poulter, Andrzej Januszewicz, Nikhil Tandon, Prashant Joshi, Simon Heller, Bruce Neal, John Chalmers
Journal: Diabetes Care (2011)

Participants in ADVANCE were drawn from many countries. We examined whether the effects of intensive glycemic control on major outcomes in ADVANCE differ between participants from Asia, established market economies (EMEs), and eastern Europe.ADVANCE was a clinical trial of 11,140 patients with type 2 diabetes, lasting a median of 5 years. Demographic and clinical characteristics were compared across regions using generalized linear and mixed models. Effects on outcomes of the gliclazide modified release-based intensive glucose control regimen, targeting an HbA(lc) of ≤6.5%, were compared across regions using Cox proportional hazards models.When differences in baseline variables were allowed for, the risks of primary outcomes (major macrovascular or microvascular disease) were highest in Asia (joint hazard ratio 1.33 [95% CI 1.17-1.50]), whereas macrovascular disease was more common (1.19 [1.00-1.42]) and microvascular disease less common (0.77 [0.62-0.94]) in eastern Europe than in EMEs. Risks of death and cardiovascular death were highest in eastern Europe, and the mean difference in glycosylated hemoglobin between the intensive and standard groups was lowest in EMEs. Despite these and other differences, the effects of intensive glycemic control were not significantly different (P ≥ 0.23) between regions for any outcome, including mortality, vascular end points, and severe hypoglycemic episodes.Irrespective of absolute risk, the effects of intensive glycemic control with the gliclazide MR-based regimen used in ADVANCE were similar across Asia, EMEs, and eastern Europe. This regimen can safely be recommended for patients with type 2 diabetes in all of these regions.