tbuckley/cabot-search huggingface dataset:
Sickle cell rheology is determined by polymer fraction–not cell morphology
Authors: Hiroyuki Hiruma, Constance Tom Noguchi, Nobuhiro Uyesaka, Setsuo Hasegawa, E. Joan Blanchette‐Mackie, Alan N. Schechter, Griffin P. Rodgers
Journal: American Journal of Hematology (1995)

Abstract Sickle cell disease pathophysiology is mediated by acute and chronic impairment of cell flexibility due to the formation of intracellular sickle hemoglobin (Hb S) polymer as cells are partially deoxygenated in the microcirculation. We have recently developed a method to measure the relationship between the formation of intracellular polymerized Hb S and cell filtration. In this study, we have used this method to examine whether sickle cell morphology, independent of Hb S polymer fraction, had an effect on cell rheology. We primarily use sickle trait (AS) and Hb S‐β + ‐thalassemia (S‐β + ‐thal) erythrocytes with low hemoglobin F levels, which have normal membranes and few or no dense cells, to remove these confounding effects. We find that the relationship between filtration and the percentages of each “type” of morphological deformation of AS erythrocytes was different from that of the S‐β + ‐thal erythrocytes. In addition, we find that while the filtration of AS erythrocytes as a function of oxygen saturation was similar, whether measured during deoxygenation or reoxygenation, the relationship between the percentages of each type of deformed erythrocyte and oxygen saturation demonstrated hysteresis during oxygenation‐deoxygenation experiments. Transmission electron microscopy, for both elongated and irregularly shaped cells, showed that similarly distorted cells could have very different amounts and alignment of polymer. These results suggests that cell morphology per se is not strongly related to filtration, whereas calculated intracellular Hb S polymer fraction predicts loss of filtration of AS and S‐β + ‐thal erythrocytes well. Measured or calculated polymer fraction values would appear to be a better parameter for the study of sickle cell disease pathophysiology and response to treatment than cell morphology studies. ©1995 Wiley‐Liss, Inc.
Fear of imminent death
Authors: R. Hurley
Journal: BMJ (2003)

Edgar Allen Poe (1809-49) shifted the boundaries of fiction in the genres of detective stories, science fiction, and tales of horror. Death—especially fear of it—is a recurring theme in Poe's work. This fascination may result from Poe's own losses: his parents died before he was 3 years old. Poe married his 13 year old cousin, Virginia, in 1836; she died at the age of 24.

Poe wrote The Masque of the Red Death while Virginia was sick with tuberculosis. …
Creation of lysine-deficient mutant lymphotoxin-α with receptor selectivity by using a phage display system
Authors: Yasuo Yoshioka, Hikaru Watanabe, Tomohiro Morishige, Xinglei Yao, Shinji Ikemizu, Chioko Nagao, Shandar Ahmad, Kenji Mizuguchi, Shin-ichi Tsunoda, Yasuo Tsutsumi, Yohei Mukai, Naoki Okada, Shinsaku Nakagawa
Journal: Biomaterials (2009)
566 Pharmacokinetics and pharmacodynamics of induction doses of peginterferon alpha-2a (40KD) (PEGASYS®) and ribavirin (COPEGUS®) in HCV genotype 1 patients who failed to respond to interferon/ribavirin
Authors: M. Diago, M. Romero-Gomez, J. Crespo, A. Olveira, R. Perez, R. Barcena, J.M. Sanchez-Tapias, M. Munoz-Sanchez
Journal: Journal of Hepatology (2006)
Plasma Digitalis: A Guide to Cardiac Effects?
Authors: William Shapiro
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Plasma Digitalis: A Guide to Cardiac Effects?William Shapiro, M.D., F.A.C.P., Kathryn Taubert, M.S., Kenneth Narahara, M.D.William Shapiro, M.D., F.A.C.P.Search for more papers by this author, Kathryn Taubert, M.S.Search for more papers by this author, Kenneth Narahara, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-822_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAccurate methods for clinical measurement of plasma glycoside concentrations promise an objective guide to the use of digoxin and digitoxin. After intravenous administration peak plasma concentrations fall rapidly (digoxin, 3 to 4 hr; digitoxin, 4 to 6 hr) through concentration levels that, in the steady state, are only seen in intoxicated patients to a slow excretion slope within the "therapeutic" concentration range (less than 3 mµg/ml digoxin; less than 40 mµg/ml digitoxin). During this period there is a significant inverse correlation (P< 0.01), with changes in the time of left ventricular ejection and Q-S2. Maximum decreases in these cardiac... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: William Shapiro, M.D., F.A.C.P.; Kathryn Taubert, M.S.; Kenneth Narahara, M.D.Affiliations: Dallas, Tex. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 822-822KeywordsAttentionBlood plasmaExcretionFallsGlycosides ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...
Non-motile sperms persisting after vasectomy: do they matter?
Authors: I S Edwards, J L Farlow
Journal: BMJ (1979)

ing.Medical journals in particular should stop immediately the implicit advertising of alcohol which often appears in their pages concerned with eating out and such recreations.It is not long since in Birmingham the BMA itself arranged a whisky tasting evening.On the other hand, with heroin we have created a "pushers' market," and our methods for handling this problem are those which have proved disastrous in America in respect of the prohibition of alcohol.In the case of alcohol
Technetium-99m-Labeled RBC Bleeding Scan in a Patient With Osler-Weber-Rendu Disease
Authors: Beth M. Blumenthal, Walter Slizofski, Matthew Hoffman
Journal: Clinical Nuclear Medicine (2004)

An 83-year-old woman presented to the emergency room from her nursing home with bright-red blood per rectum. Her vital signs were stable and she had a low hemoglobin level of 8 g/100 mL. A radionuclide bleeding scan demonstrated pooling of labeled red blood cells within focally dilated postcapillary venules of telangiectasias, and arteriovenous malformations associated with Osler–Weber–Rendu disease, similar to the appearance of hemangiomas. Correlative CT scans showed arteriovenous shunting and angiodysplasia in the liver with peripheral vascular pooling. They also demonstrated angiodysplasia adjacent to the left internal iliac artery.
Reestablishment of Pulmonary-Artery Flow After Prolonged Complete Occlusion
Authors: Thomas Gahagan
Journal: JAMA (1966)

The ability of the pulmonary vascular bed to accept normal blood flow after prolonged occlusion is important in corrective procedures for tetralogy of Fallot. Preparation of the pulmonary bed by systemic pulmonary shunt prior to complete correction has been considered advantageous by some. Although the final answer to this question will probably come from surgical statistics rather than laboratory experimentation, we thought it would be of interest to study pulmonary blood flow in dogs following reanastomosis of the pulmonary artery after periods of complete occlusion. <h3>Methods</h3> Direct measurement of left-lung blood flow in dogs weighing in the vicinity of 10 kg (22 lb) was obtained by individual cannulation of the three left pulmonary veins. Measurements were taken during a state of steady flow with mean systemic pressure maintained at 100 mm Hg and the blood volume kept constant by venous infusion of blood equal to that removed for measurement. Total
Cause of unexplained anaemia.
Authors: C. M. Stanbridge, P. C. Srivastava
Journal: BMJ (1968)

Cause of Unexplained AnaemiaSIR,-There is a high incidence of thalassaemia trait in large areas of the Indian subcontinent.This should always be borne in mind when investigating apparently simple iron-deficiency anaemias in the immigrant population.The finding of ankylostoma eggs may be a red herring, as the unsatisfactory response to iron therapy (oral or intravenous) will sooner or later reveal.We have recently picked up four such cases in patients whose faeces contained eggs of the parasite.They were admitted for various conditions such as cerebral vascular accidents, appendicitis, pregnancy, and pneu- monia.Despite a low serum and stainable bone marrow iron content, after iron medication the haemoglobin values showed no significant improvement and the morphological changes in the red cells remained largely unaltered.However, the number of cells with punctate basophilia increased, and the diagnosis of /8-thalassaemia was subsequently confirmed by the presence of abnormal amounts of HbA2 (4.2 to 6.3%/o).These observations underline the im- portance of quantitating haemoglobin A2, especially in immigrants originating from the northern regions of India and West Pakistan, particularly the Muslim section, in whom the incidence of the /-thalassaemia trait would seem to be the highest.-Weare, etc.,
Subcellular distribution of Ca2+ pumping sites in human neutrophils.
Authors: K H Krause, P D Lew
Journal: Journal of Clinical Investigation (1987)

The distribution of nonmitochondrial Ca2+ pumping sites and the site of action of inositol 1,4,5-trisphosphate (Ins 1,4,5-P3) were studied in subcellular fractions of human neutrophils. In homogenates, two different Ca2+ pools could be observed: a mitochondrial Ca2+ pool and a nonmitochondrial, ATP-dependent, Ins 1,4,5-P3-responsive Ca2+ pool. When the homogenate was separated into microsomes, primary granules, and secondary granules, the nonmitochondrial Ca2+ pumping and the Ins 1,4,5-P3-induced Ca2+ release occurred only in the microsomal fraction. In a gradient developed to separate different microsomal organelles, maximal Ca2+ pumping activity occurred in fractions of low densities. Correlations between Ca2+ uptake and organelle markers were negative for the endoplasmic reticulum (r = -0.49) and positive for plasma membrane (r = 0.47), Golgi (r = 0.62), and endosomes (r = 0.96). Because the Ca2+ pumping organelles in these fractions were insensitive to micromolar vanadate and digitonin treatment, they are unlikely to be plasma membrane vesicles. We conclude first that microsomal fractions of human neutrophils contain organelles that lower the ambient free Ca2+ concentration and respond to Ins 1,4,5-P3. Second, granules are not involved in intracellular Ca2+ regulation in neutrophils. Third, nonendoplasmic reticulum organelles, such as endosomes, Golgi elements, or yet undefined specialized structures, play a major role in intracellular Ca2+ homeostasis in human neutrophils.
Multiple Myeloma Precursor Disease
Authors: Ola Landgren, Adam Justin Waxman
Journal: JAMA (2010)

Recent data indicate that multiple myeloma is consistently preceded by the precursor states of monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma. Currently, multiple myeloma is a clinical diagnosis based on manifestations including hypercalcemia, renal failure, anemia, and bone lesions, whereas MGUS and smoldering myeloma are diagnosed based on laboratory abnormalities. Current clinical markers allow for more individualized risk stratification and counseling of these patients. However, there is a dearth of biomarkers and molecular imaging techniques capable of (1) accurately identifying patients with disease biology corresponding with high risk of progression; (2) elucidating the mechanism of transformation to multiple myeloma; and (3) forming a framework for development of targeted therapies. This case presentation and review discusses the current understanding of myeloma precursor disease and future opportunities for improving personalized management of patients with MGUS or smoldering myeloma, as well as the potential for developing early treatment strategies designed to delay and prevent development of multiple myeloma.
Getting to grips with Archie Cochrane's agenda.
Authors: I. Chalmers, K. Dickersin, T. C. Chalmers
Journal: BMJ (1992)

of effective guidelines.One prerequisite is an ongoing review of evidence on the outcome of different approaches to management.This has been done for perinatal care and so far over 5000 perinatal trials have been identified and classified."Guidelines should be based on the best available evidence, and assembling this is hard work.Help is at hand.The proposed Cochrane Centre will have an important role in fostering systematic, up to date reviews of controlled trials (see next editorial)."2Leeds has a clearing house for assessing health services' outcomes, which circulates a quarterly bulletin.'3In future, a guideline coordinating centre could collaborate closely with the royal colleges, which have already worked in this area,14-'6 and other local, national, and international bodies.Guidelines are not static and must be continually updated to take account of changes in medical knowledge and practice and particularly the results of randomised trials and meta-
Update: A 39-Year-Old Man With HIV-Associated Lipodystrophy
Authors: Neha S. Trivedi, Howard Libman
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
515 VIROLOGICAL BREAKTHROUGH AND GENOTYPIC RESISTANCE IN A RANDOMIZED, CONTROLLED STUDY ON TELBIVUDINE TREATMENT APPLYING ROADMAP CONCEPT IN CHB: W76 INTERIM ANALYSIS OF EFFORT STUDY
Authors: J. Hou, J. Sun, Q. Xie, D. Tan, Q. Ning, J. Niu, X. Bai, S. Chen, J. Cheng, Y. Yu, H. Wang, M. Xu, G. Shi, M. Wan, X. Chen, H. Tang, J. Sheng, X. Dou, J. Shi, H. Ren, M. Wang, H. Zhang, Z. Gao, C. Chen, H. Ma, J. Jia, H. Zhuang
Journal: Journal of Hepatology (2012)
Health Care, Science and the New Administration
Authors: Daniel S. Greenberg
Journal: New England Journal of Medicine (1976)

Health Care, Science and the New AdministrationLet us look at some of the problems that the Carter Administration will inherit in health care and science.These are areas in which the federal presence is financially and administratively so large that activity, or even inactivity, in Washington affects them throughout the nation. The odds, however, favor some decisive steps by the new Administration. This is not merely because of campaign assurances, many of which, after all, can be expected to fade as Carter and his appointees encounter the realities of governance. Rather, health care and the scientific enterprise are afflicted . . .
Chikungunya virus is a cause of encephalitis in children in bellary, India
Authors: Penny Lewthwaite, Ashia Begum, M. Veerahsankar, R. Ravikumar, Anita Desai, Jane Osborne, Jenna Plank, Roger Hewson, V. Ravi, Nick Beeching, Tom Solomon
Journal: Journal of Infection (2008)
Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1
Authors: Kenneth W. Harder, Cathy Quilici, Edwina Naik, Melissa Inglese, Nicole Kountouri, Amanda Turner, Kristina Zlatic, David M. Tarlinton, Margaret L. Hibbs
Journal: Blood (2004)

The Lyn tyrosine kinase plays essential inhibitory signaling roles within hematopoietic cells by recruiting inhibitory phosphatases such as SH2-domain containing phosphatase-1 (SHP-1), SHP-2, and SH2-domain containing 5'-inositol phosphatase (SHIP-1) to the plasma membrane in response to specific stimuli. Lyn-deficient mice display a collection of hematopoietic defects, including autoimmune disease as a result of autoantibody production, and perturbations in myelopoiesis that ultimately lead to splenomegaly and myeloid neoplasia. In this study, we demonstrate that loss of Lyn results in a stem/progenitor cell-intrinsic defect leading to an age-dependent increase in myeloid, erythroid, and primitive hematopoietic progenitor numbers that is independent of autoimmune disease. Despite possessing increased numbers of erythroid progenitors, and a more robust expansion of these cells following phenylhydrazine challenge, Lyn-deficient mice are more severely affected by the chemotherapeutic drug 5-fluorouracil, revealing a greater proportion of cycling progenitors. We also show that mice lacking SHIP-1 have defects in the erythroid and myeloid compartments similar to those in mice lacking Lyn or SHP-1, suggesting an intimate relationship between Lyn, SHP-1, and SHIP-1 in regulating hematopoiesis.
Subjective Colour Phenomena
Authors: S. Bidwell
Journal: BMJ (1897)

IN a recent communication to the Royal Society,1 I described a series of optical experiments which originated in an attempt to account for the colour phenomena exhibited by Mr. C. E. Benham's “Artificial Spectrum Top” (NATURE, vol. li. p. 113). The chief of these experiments are of an exceedingly simple character, and can easily be repeated without the employment of any special apparatus. They demonstrate the formation, under certain conditions, of transient bands of colour along the boundaries between light and dark surfaces.
Case 11-1971
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. McNeely, Alan C. Aisenberg, Austin L. Vickery
Journal: New England Journal of Medicine (1971)

Presentation of Case First admission. A 76-year-old man was admitted to the hospital because of pulmonary lesions.He had been well until seven years previously, when cervical and inguinal lymphadenopathy developed. Biopsy of one of the lymph nodes disclosed lymphoblastic lymphoma; a course of radiation to the enlarged nodes was followed by complete regression. He was well thereafter, working daily until a few months before admission, when a cough, anorexia and listlessness occurred. One month before entry, because of weakness and nausea, he entered another hospital, where x-ray films of the chest disclosed multiple nodular lesions in the left . . .
Infection Control in Intravenous Therapy
Authors: DENNIS G. MAKI
Journal: Annals of Internal Medicine (1973)

The intravenous infusion has become indispensable in modern medical therapy, but infection, especially infusion-associated septicemia, remains a life-threatening hazard. In 1970 to 1971 a nationwide epidemic of nosocomial Gram-negative septicemia, traced by the Center for Disease Control to one supplier's contaminated infusion products, dramatically focused attention on the problem of infusion-related infection. Contamination of the intravenous system can occur at virtually any point, from the time of manufacture until the infusion is terminated in the hospital. Once contaminated, the intravenous cannula and its adherent thrombus can serve as an intravascular nidus for the proliferation and dissemination of microorganisms. Some pathogens grow luxuriantly in infusion fluids at room temperature, attaining concentrations exceeding 105 organisms per millilitre in 24 hours. Moreover, contamination of infusion fluid in use is probably common and must now be recognized as a potential cause of septicemia.
Patients with emergency brain disorders are denied specialist care
Authors: A. Ferriman
Journal: BMJ (2002)

The number of consultant neurologists needs to expand from the present 350 to between 1000 and 1400 if Britain is to have a comprehensive service for all acute neurological emergencies in adults, a new report says.

Patients who are critically ill should be seen immediately, and all other acutely ill patients should be seen by a neurologist within 24-48 hours, the report from the Association of British Neurologists says.

At present many patients who are acutely ill with neurological conditions such as epilepsy, Guillain-Barre syndrome, and stroke may not see a neurologist for several days, if at all.

Yet when such …
Experiments are the key to understanding socially acquired knowledge in cetaceans
Authors: Eduardo Mercado, Caroline M. DeLong
Journal: Behavioral and Brain Sciences (2001)

We agree with Rendell and Whitehead that cetaceans acquire knowledge from caretakers and peers, and that a clear understanding of this process can provide insight into the evolution of mammalian cognition. The passive observational methods they advocate, however, are inadequate for determining what cetaceans know. Only by experimentally investigating the cognition of cetaceans can we hope to understand what they learn through social interactions.
Laboratory Guide in Experimental Pharmacology. Directions for the Course Given in the University of Michigan.
Authors: Charles Wallis Edmunds, Arthur R. Cushny
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Radiation Myelopathy Visualized as Increased FDG Uptake on Positron Emission Tomography
Authors: Wichana Chamroonrat, Anthony Posteraro, Ghassan El-Haddad, Hongming Zhuang, Abass Alavi
Journal: Clinical Nuclear Medicine (2005)

A woman with a history of desmoid tumor involving the T9-T10 vertebrae was treated with local irradiation. After treatment, she developed tingling sensations in both legs. An FDG PET study demonstrated focally increased activity posterior to the vertebral bodies at the levels of T9-T10, which was vertical in orientation, corresponding to the location of the spinal cord at this level. This finding is consistent with the clinical suspicion of radiation myelopathy.
Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes
Authors: Joseph C. Mudd, Patrick Murphy, Maura Manion, Robert Debernardo, Jeffrey Hardacre, John Ammori, Gareth A. Hardy, Clifford V. Harding, Ganapati H. Mahabaleshwar, Mukesh K. Jain, Jeffrey M. Jacobson, Ari D. Brooks, Sharon Lewis, Timothy W. Schacker, Jodi Anderson, Elias K. Haddad, Rafael A. Cubas, Benigno Rodriguez, Scott F. Sieg, Michael M. Lederman
Journal: Blood (2013)