tbuckley/cabot-search huggingface dataset:
Multiple-Sensor Systems for Physiologic Cardiac Pacing
Authors: David G. Benditt
Journal: Annals of Internal Medicine (1994)

Purpose: To review the status of artificial sensors in cardiac pacemakers and the rationale for developing pacing systems that use multiple sensors. Data Sources: Journal articles published between 1982 and 1993 indexed in MEDLINE using the keywords pacemakers, sensors, and rate-adaptive, as well as abstracts and articles in the authors' personal files. Study Selection: Articles describing clinical experience with or clinical evaluation of cardiac pacing systems using multiple artificial sensors. Data Synthesis: Artificial sensors were created to adjust pacing rate reliably in response to changes in levels of physical exertion for patients with sinoatrial disease in whom exercise heart rate response is inadequate (for example, chronotropic incompetence in sinoatrial disease). To achieve this, various artificial sensors were developed and many reports confirm improved exertional tolerance. More recently, sensors have assumed a greater role in cardiac pacemakers. For example, sensors are used to permit automatic adjustment of certain programmable pacemaker settings, such as the atrioventricular interval. In the future, they may also be used to maximize pacemaker longevity by automatically optimizing energy output (voltage, pulse width). No single sensor is ideal for all potential applications, and investigators have advocated using two or more sensors. Several pacemakers that use multiple sensors with different but complementary operating characteristics are already commercially available outside the United States. Although preliminary findings are encouraging, additional clinical experience with these pacemakers is needed to determine their ultimate role in clinical practice. Conclusion: Simultaneous use of multiple complementary artificial sensors may permit development of cardiac pacemakers that operate more physiologically yet require less specialized medical follow-up.
Relationships between liver histologic lesions and portal hypertension in patients with alcoholic cirrhosis
Authors: Thierry Poynard, Claude Degott, Didier Lebrec, Hector Orrego, Yedy Israel, Joan E. Blake, L. M. Blendis, R. Britton, Kim Krogsgaard, Christian Gluud, Jens H. Henriksen, Per Christoffersen
Journal: Hepatology (1985)
Cardiovascular Safety of Inhaled Long-Acting Bronchodilators in Individuals With Chronic Obstructive Pulmonary Disease
Authors: Andrea Gershon, Ruth Croxford, Andrew Calzavara, Teresa To, Matthew B. Stanbrook, Ross Upshur, Thérèse A. Stukel
Journal: JAMA Internal Medicine (2013)

Chronic obstructive pulmonary disease (COPD) is a common and deadly disease. Long-acting inhaled β-agonists and anticholinergics, first-line medications for COPD, have been associated with increased risk of cardiovascular outcomes. When choosing between the medications, patients and physicians would benefit from knowing which has the least risk.To assess the association of these classes of medications with the risk of hospitalizations and emergency department visits for cardiovascular events.We conducted a nested case-control analysis of a retrospective cohort study. We compared the risk of events between patients newly prescribed inhaled long-acting β-agonists and anticholinergics, after matching and adjusting for prognostic factors.Health care databases from Ontario, the largest province of Canada, with a multicultural population of approximately 13 million.All individuals 66 years or older meeting a validated case definition of COPD, based on health administrative data, and treated for COPD from September 1, 2003, through March 31, 2009.New use of an inhaled long-acting β-agonist or long-acting anticholinergic.An emergency department visit or a hospitalization for a cardiovascular event.Of 191 005 eligible patients, 53 532 (28.0%) had a hospitalization or an emergency department visit for a cardiovascular event. Newly prescribed long-acting inhaled β-agonists and anticholinergics were associated with a higher risk of an event compared with nonuse of those medications (respective adjusted odds ratios, 1.31 [95% CI, 1.12-1.52; P < .001] and 1.14 [1.01-1.28; P = .03]). We found no significant difference in events between the 2 medications (adjusted odds ratio of long-acting inhaled β-agonists compared with anticholinergics, 1.15 [95% CI, 0.95-1.38; P = .16]).Among older individuals with COPD, new use of long-acting β-agonists and anticholinergics is associated with similar increased risks of cardiovascular events. Close monitoring of COPD patients requiring long-acting bronchodilators is needed regardless of drug class.
Observations on the Electrocardiogram and Ventricular Gradient in Complete Left Bundle Branch Block
Authors: J. F. PANTRIDGE
Journal: Circulation (1951)

Electrocardiograms from 109 patients with left bundle branch block were divided into four major groups depending on differences in standard and unipolar precordial leads. These records were then studied to find if one can draw any conclusions relative to ventricular hypertrophy or myocardial infarction in the presence of left branch block. In addition, the ventricular gradient was estimated in twenty-three instances and its value discussed.
An intermediate cell in thymocyte differentiation that expresses CD8 but not CD4 antigen.
Authors: D J Paterson, A F Williams
Journal: The Journal of Experimental Medicine (1987)

Thymocytes of CD4-,CD8+,OX-44- phenotype have been shown to be an intermediate of thymopoiesis that give rise to cells of CD4+, CD8+, OX-44- normal cortical thymocyte phenotype both in vitro and in vivo during thymic regeneration.
Virus-Like Particles in a Patient with Chronic Lymphocytic Leukemia
Authors: Michael V. Viola, Albert J. Dalton, Elizabeth Mitchell, John B. Moloney
Journal: New England Journal of Medicine (1967)

THE presence of viruses in the plasmas of laboratory animals with induced leukemia stimulated interest in attempts to find similar particles in the plasma of patients with leukemia. Previous reports have described "C"-type particles in the plasma of a small percentage of patients.1 , 2 These particles are characteristic of those known to be etiologically related to murine leukemia. The present report describes studies on a patient with chronic lymphocytic leukemia with plasma that has persistently yielded a virus-like particle not previously described.Case ReportL.B. (N.I.H. 07–23–74), a 57-year-old woman, was well until January, 1964, when she was admitted to the . . .
Elevated levels of IL-8 in interstitial pneumonia induced by low-dose methotrexate
Authors: Satoshi Yoshida, Kazuya Onuma, Kazuhito Akahori, Hideo Sakamoto, Yoko Yamawaki, Tatsuhiro Shoji, Hiroshi Nakagawa, Hiroshi Hasegawa, Hideaki Amayasu
Journal: Journal of Allergy and Clinical Immunology (1999)
Ibuprofen and Renal Disease
Authors: Sandy A. Furey
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 September 1990Ibuprofen and Renal DiseaseSandy A. Furey, PhD, MDSandy A. Furey, PhD, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-6-481 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:Whelton and colleagues (1) have noted an increase in serum creatinine or potassium in 3 of 12 patients with "asymptomatic, mild but stable chronic renal failure" who received Ibuprofen, 800 mg three times a day, and in 2 of those 3 patients receiving Ibuprofen, 400 mg three times a day, for up to 11 days. Concluding that these findings are of particular concern to users of nonprescription Ibuprofen is puzzling: The average glomerular filtration rate for the 3 patients who showed an increase in serum creatinine or potassium was approximately 24.6 mL/min, a far more serious degree...References1. WheltonStoutSpillmanKlassen ARPD. Renal effects of Ibuprofen, Piroxicam, and sulindac in patients with asymptomatic renal failure. A prospective, randomized, crossover comparison. Ann Intern Med. 1990;112:568-76. LinkGoogle Scholar2. WheltonStoutDrew ARH. A prospective, randomized, cross-over study of the renal effects of three non-steroidal drugs (NSAID) in chronic renal impairment [Abstract]. J Clin Pharmacol. 1988;28:919. Google Scholar3. CummingsAmadioNettler DPS. Office-based evaluation of renal function in elderly patients receiving nonsteroidal anti-inflammatory drugs. J Am Board Fam Pract. 1988;1:77-80. MedlineGoogle Scholar4. FoxJick DH. Nonsteroidal anti-inflammatory drugs and renal disease. JAMA. 1984;251:1299-300. CrossrefMedlineGoogle Scholar5. MeyerTemple HR. Labeling of ibuprofen for over-the-counter use [Letter]. N Engl J Med. 1985;312:377. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Sandy A. Furey, PhD, MDAffiliations: Whitehall Laboratories New York, NY 10017 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRenal ToxicityIbuprofen: pharmacology, efficacy and safetyPartner Notification: Operational Considerations 15 September 1990Volume 113, Issue 6Page: 481-481KeywordsCreatinineGlomerular filtration rateIbuprofenPotassiumRenal diseasesRenal failure ePublished: 1 December 2008 Issue Published: 15 September 1990 PDF downloadLoading ...
A Canadian multicenter retrospective study evaluating transjugular liver biopsy in patients with congenital bleeding disorders and hepatitis C: Is it safe and useful?
Authors: Jennifer L. Shin, Jerome Teitel, Mark G. Swain, Vincent G. Bain, Paul C. Adams, Kenneth Croitoru, Kevork Peltekian, Frank Schweiger, Martin E. Simons, E. Jenny Heathcote
Journal: American Journal of Hematology (2005)

Prior to the introduction of virally inactivated clotting factor concentrates, the majority of individuals with congenital bleeding disorders became infected with the hepatitis C virus. Although liver biopsy is valuable in prognosis and guiding antiviral therapy, there is a reluctance to perform biopsies in this population because of the risk of hemorrhage. The purpose of this study was to evaluate the safety of transjugular liver biopsy, and the usefulness of evaluating liver histology in this patient population. Liver histopathology was assessed by the METAVIR index and compared with corrected sinusoidal pressures, platelet counts, and abdominal ultrasonography. Liver biopsy was performed at seven Canadian centers in 65 patients with hemophilia or von Willebrand's disease. Biopsies were done on an outpatient basis, followed by a 4-hr observation period in hospital. Normal hemostasis was maintained during the peribiopsy period, with follow-up doses of factor concentrate self administered by the patient at home. One patient (1.4%) had significant bleeding leading to readmission and red cell transfusion. Liver histology showed 14 patients (22%) had cirrhosis. Ten patients had elevated corrected sinusoidal pressures; 7 of these (70%) had cirrhosis on biopsy, and the other 3 (30%) likely had cirrhosis although histology showed stage 3 fibrosis. This series represents the largest reported experience of transjugular biopsy in individuals with congenital bleeding disorders. We conclude that this procedure can be safely performed on an outpatient basis. The diagnosis of cirrhosis and/or portal hypertension was made in a substantial proportion of individuals (26%), all of whom had asymptomatic liver disease.
No Association between Coffee Consumption and Adverse Outcomes of Pregnancy
Authors: Shai Linn, Stephen C. Schoenbaum, Richard R. Monson, Bernard Rosner, Phillip G. Stubblefield, Kenneth J. Ryan
Journal: New England Journal of Medicine (1982)

We analyzed interview and medical-record data of 12,205 non-diabetic, non-asthmatic women to evaluate the relation between coffee consumption and adverse outcomes of pregnancy. Low birth weight and short gestation occurred more often among offspring of women who drank four or more cups of coffee a day and more often among the offspring of smokers. After controlling for smoking, other habits, demographic characteristics, and medical history by standardization and logistic regression, we found no relation between low birth weight or short gestation and heavy coffee consumption. Furthermore, there was no excess of malformations among coffee drinkers. These negative results suggest that coffee consumption has a minimal effect, if any, on the outcome of pregnancy.
A Re-evaluation of 12S Ribosomal RNA Variability in Drosophila pseudoobscura
Authors: Mohamed A. F. Noor, John C. Larkin
Journal: Molecular Biology and Evolution (2000)

Two recent studies have presented conflicting views on variation present within the 294 base third domain of the 12S rRNA gene in the genus Drosophila, and in D. pseudoobscura in particular. One study suggested that this gene is highly invariant across the genus, while another recovered 22 distinct haplotypes from 22 strains of D. pseudoobscura. We have sequenced this gene in numerous lines of D. pseudoobscura and its relatives, noting only two haplotypes in the third domain, and we failed to confirm any of the published sequences. Second, we note that the published sequence divergence between strains of D. pseudoobscura was as great as that documented between distantly related Drosophila species. Third, we show that the published polymorphisms of this region within D. pseudoobscura would disrupt the secondary structure of the resulting molecule. We conclude that the published 12S rRNA sequences of D. pseudoobscura do not accurately reflect variability of the functional gene, and that this gene is relatively invariant in D. pseudoobscura and D. persimilis.
Vagotomy and gallbladder function
Authors: S. Fagerberg, S. Grevsten, H. Johansson, U. Krause
Journal: Gut (1970)

The effect of vagotomy on gallbladder function was investigated in a clinical and experimental study. In the clinical study both the size of the gallbladder and its capacity to respond to cholecystokinin were evaluated radiologically before and after vagotomy. In studies in the rabbit, both the immediate effect of vagotomy on the gallbladder and the effect of varying doses of cholecystokinin on gallbladder pressure were studied before and after vagotomy. In studies in the cat the long-term effect of vagotomy was studied with respect to the histology of the gallbladder and the composition of bile. The clinical investigation showed that vagotomy was followed by a significant increase in the volume of the gallbladder and that the effect of the cholecystokinin on the gallbladder remained unchanged after vagotomy. In experiments in the rabbit it was found that cholecystokinin in a dose of 1 unit/kg body weight exerted a somewhat lesser effect on gallbladder pressure after vagotomy than before, while after vagotomy a dose, approximately four times greater, resulted in a stronger gallbladder response. Further, the experiments showed that the chemical composition of the bile seemed to be altered after vagotomy, while the gallbladder remained histologically essentially unchanged.
Conference on Indications for Tonsillectomy and Adenoidectomy
Authors: Jack L. Paradise, Charles D. Bluestone, Kenneth D. Rogers, Robert J. Ruben
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The COMMENTARY by Terrence S. Carden, Jr, MD (240:1961, 1978), "Tonsillectomy—Trials and Tribulations: Report on the National Institutes of Health Consensus Conference on Indications for Tonsillectomy and Adenoidectomy," provides a reasonable summary of the conference's background and some of its discussion but focuses on negative aspects and ends with an unjustified and irrational conclusion. The panel's specific charge was to review and evaluate a report to the National Institutes of Health that had recommended a multicenter study as the only feasible way to address the tonsillectomy and adenoidectomy issue. As Dr Carden accurately reported, the panel concluded that a multicenter study was not the only feasible way, and that, in fact, the feasibility of a multicenter study was itself open to question. On the other hand, nothing in the panel's deliberations suggested what Dr Carden describes as "the inability to develop a study of unassailable scientific validity."
Osteoblastoma of the Mandible Mimicking Osteosarcoma in FDG PET/CT Imaging
Authors: Klaus Strobel, Michael Merwald, Martin Huellner, Hans R. Zenklusen, Johannes Kuttenberger
Journal: Clinical Nuclear Medicine (2013)

Osteoblastomas are rare tumors accounting for approximately 1% of all primary bone tumors. We report a case of osteoblastoma of the mandible with high FDG uptake. Initially, this lesion was judged as an osteosarcoma. Osteoblastomas are benign slow-growing tumors. High-resolution thin-slice CT images of the lesion as part of the PET/CT study help to characterize its morphology and extension, thus facilitating biopsy planning and resection. Approximately 25% of osteoblastomas initially have the imaging appearance of a malignant tumor. In our case, complete resection of the lesion followed by reconstruction with a bone graft was performed.
Anterior leaflet procedures during mitral valve repair do not adversely influence long-term outcome
Authors: Eugene A Grossi, Aubrey C Galloway, LeBoutillier Martin, Bryan Steinberg, F.Gregory Baumann, Julie Delianides, Frank C Spencer, Stephen B Colvin
Journal: Journal of the American College of Cardiology (1995)

Objectives. This study was done to assess the impact of anterior mitral leaflet reconstructive procedures on initial and long-term results of mitral valve repair. Background. It has been suggested that involvement of the anterior leaflet in mitral valve disease adversely affects the long-term outcome of mitral valve repair. Our policy has been to aggressively repair such anterior leaflets with procedures that include triangular resections in some cases. Methods. From June 1979 through June 1993, 558 consecutive Carpentier-type mitral valve repairs were performed. The anterior mitral leaflet and chordae tendineae were repaired in 156 patients (mean age 58 years). The procedures included anterior chordal shortening in 78 patients (50%), anterior leaflet resections in 44 (28%), resuspension of the anterior leaflet to secondary chordae in 42 (27%) and anterior chordal transposition in 27 (17%). Concomitant cardiac surgical procedures were performed in 75 patients (48%). Results. The operative mortality rate was 2.5% (2 of 81) for isolated mitral valve anterior leaflet repair and 3.8% (6 of 156) for all mitral valve anterior leaflet repair. Freedom from reoperation at 5 and 10 years was, respectively, 89.7% (n = 160) and 83.4% (n = 24) for the entire series of 558 patients, 91.9% (n = 51) and 81.2% (n = 10) for patients with anterior leaflet procedures, 88.8% (n = 109) and 84.4% (n = 14) for patients without anterior leaflet procedures and 91.7% (n = 118) and 88.9% (n = 18) for patients without rheumatic disease. Logistic regression showed that rheumatic origin of disease (odds ratio 2.99), but not anterior leaflet repair, increased the risk for reoperation. Conclusions. These results demonstrate that expansion of mitral valve techniques to include anterior leaflet disease yields immediate and long-term results equal to those seen in patients with posterior leaflet disease.
Letter by Papageorgiou et al Regarding Article, “OMEGA, A Randomized, Placebo-Controlled Trial to Test the Effect of Highly Purified Omega-3 Fatty Acids on Top of Modern Guideline-Adjusted Therapy After Myocardial Infarction”
Authors: Nikolaos Papageorgiou, Dimitris Tousoulis, Christodoulos Stefanadis
Journal: Circulation (2011)
Sir Hans Sloane (1660-1753)
Authors: M. K. McPhaill
Journal: JAMA (1965)

<h3>To the Editor:—</h3> I wish to draw to your attention an error that appeared in the May 24th issue (<i>JAMA</i><b>192</b>:713-714, 1965), in the biobraphical sketch which dealt with William Hogarth (1697-1764). It is stated that Sir Hans Sloan (correctly Sloane) was the founder of the Royal Society. This is the second time this year that I have seen Sloane referred to as the founder of the Royal Society. He was a Fellow of the Society and succeeded Sir Isaac Newton as President, but the Society had its origin some years before Sloane was born and received its first charter in 1662. I cannot imagine how the author made this mistake and am curious to know if you can enlighten me.
Tricyclic Antidepressants And Phenothiazines
Authors: D. H. Manier
Journal: JAMA (1974)

<h3>To the Editor.—</h3> The combination of a tricyclic antidepressant with a phenothiazine is frequently used in the treatment of the schizoaffective schizophrenic exhibiting depressive symptoms, and two such preparations (Triavil and Etrafon) are marketed in this country. Little is known about their interaction beyond their reported synergism in producing a central anticholinergic toxicity when given with an anticholinergic anti-parkinsonian agent. With the use of a sensitive and dependable fluorometric method for the assay of butaperazine (Repoise) maleate in human plasma, the effects of desipramine hydrochloride (Norpramin) on the plasma levels of this phenothiazine derivative were studied. Eight schizophrenic patients whose liver function tests and bloodchemistry were normal, and who had received no medication for at least one week, were studied. Random assignment with a crossover design was used, utilizing subjects as their own controls. Butaperazine tablets (20 mg) were given at 9 am and 9 pm daily, and daily
Bird flu adds to Sudan's woes as UN warns of risk to aid operations
Authors: Peter Moszynski
Journal: BMJ (2006)

As the Darfur crisis spilled over into Chad this month, a United Nations' official warned that relief operations could collapse within weeks or months because of violence and intimidation, restrictions on aid staff, and lack of funding. Sudanese militias have reportedly been attacking a refugee camp, and Khartoum is accused of backing a rebel attack on Ndjamena, the capital of Chad. Meanwhile, news that bird flu had arrived in a country in such chaos prompted further concern.

Guido Sabatinelli, the World Health Organization's representative in Sudan, told the BMJ, “As a result of the current humanitarian …
A Bi-Center Cardiovascular Magnetic Resonance Prognosis Study Focusing on Dobutamine Wall Motion and Late Gadolinium Enhancement in 3,138 Consecutive Patients
Authors: Sebastian Kelle, Eike Nagel, Andreas Voss, Nina Hofmann, Gitsios Gitsioudis, Sebastian J. Buss, Amedeo Chiribiri, Ernst Wellnhofer, Christoph Klein, Christopher Schneeweis, Christina Egnell, Juliane Vierecke, Alexander Berger, Evangelos Giannitsis, Eckart Fleck, Hugo A. Katus, Grigorios Korosoglou
Journal: Journal of the American College of Cardiology (2013)