tbuckley/cabot-search huggingface dataset:
Mobile phone tracking could help target aid after disasters, study shows
Authors: S. Mayor
Journal: BMJ (2011)

Using mobile phones to track the movement of people after a disaster could help to deliver humanitarian aid more effectively, researchers have said after finding that the results of such tracking correlated well with people’s migration after the Haiti earthquake last year.

After the earthquake and during the ensuing cholera epidemic in Haiti, researchers monitored data on the position of subscriber identity module (SIM) cards from the island’s largest mobile phone company by tracking the location of the mobile phone tower connected during calls. They noted the daily positions of SIM cards 42 days before the earthquake and 158 days …
The Voyage Continues
Authors: James P. Evans
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of Diabetes Education on Self-Care, Metabolic Control, and Emotional Well-Being
Authors: Richard R Rubin, Mark Peyrot, Christopher D Saudek
Journal: Diabetes Care (1989)

Participants (n = 165) entering a week-long outpatient education program completed a protocol measuring self-care patterns, glycosylated hemoglobin levels, and emotional well-being. Emotional well-being was reassessed at the end of the program, and the entire protocol was completed again at 6 mo (n = 124). At the program's end, participants improved on all measures of emotional well-being (P &amp;lt; .01). Self-esteem and diabetes self-efficacy rose, whereas anxiety and depression fell. At 6 mo, improvement in emotional well-being continued, and important self-care behaviors improved from preprogram levels. Self-monitoring of blood glucose and exercise rose (both P &amp;lt; .001), and binging (P &amp;lt; .01) and glycosylated hemoglobin levels (P &amp;lt; .001) fell. Program effects were unrelated to demographic or disease characteristics but strongly related to initial status. Participants who entered the program with high levels of emotional well-being or good self-care patterns or glycemic control tended to change little, if at all, at later measurements. On the other hand, people who entered the program with low levels of emotional well-being or with poor self-care patterns or glycemic control improved substantially. Our findings suggest that diabetes education can promote long-term benefits in self-care, metabolic control, and emotional status if the program is specifically designed to provide these benefits. Aspects of the program that contribute to its efficacy are discussed.
Epicardial ST Depression in Acute Myocardial Infarction
Authors: Danshi Li, Chuan Yong Li, Ah Chot Yong, Peter R. Johnston, David Kilpatrick
Journal: Circulation Research (1999)

The presence of electrocardiographic ST depression in acute infarction remains controversial and poorly explained. A combined animal and modeling study was performed to evaluate the source of ST changes in acute infarction. In anaesthetized sheep, small infarcts showed uniform ST elevation over the infarction whereas larger infarcts showed marked ST depression over the normal myocardium in addition to the ST elevation. These findings were replicated by bidomain models of the heart. A hollow sphere was used to model a gradually increasing infarct, and this showed that there was a decrease in the ratio of ST elevation to ST depression as the infarct was increased. The current flowing out of the heart must be identical to the current flowing back into the heart. This means that any infarction will produce ST depression as well as ST elevation, the ratio between the two being related to the size of the infarction. Small infarction is associated with a small region of ST elevation and minor ST depression of the remaining myocardium, and as the infarct region increases, the amplitude of the epicardial ST elevation falls and the amplitude of the ST depression increases. Infarction size is proportional to both the height of the ST depression on the epicardium and the strength of the epicardial ST segment dipole.
Increase of intravascular blood volume in ischaemic heart disease
Authors: G. GABOR, M. ISTVANFFY, M. HALMAGYI
Journal: Cardiovascular Research (1976)

Circulating blood volume, cardiac index, heart rate, and ejection rate were measured in patients with angina pectoris. The controls and the patients were divided in sub-groups of those under 45 and over 45 years of age. The investigation was carried out using the isotope method. A significant difference was observed in the value of intravascular blood volume at rest between the controls and patients with ischaemic heart disease unrelated to anginal attack. The blood volume was 5.6 litre in the control group and 6.4 litre in patients with ischaemic heart disease. Exercise tests produced further increases during attack in the blood volume of angina patients. A significant increase of blood volume after moderate exercise was also observed in patients under 45 with ischaemic heart disease but without angina. It is suggested that the increase of intravascular blood volume plays a part in the pathogenesis of angina pectoris.
IMPACT OF CALCIUM DISTRIBUTION FOR SUCCESSFUL REVASCULARIZATION OF CTO: ASSESSMENT FROM COMPUTED TOMOGRAPHY CORONARY ANGIOGRAPHY
Authors: Motoharu Araki, Toshiya Muramatsu, Reiko Tsukahara, Yoshiaki Ito, Hiroshi Ishimori, Keisuke Hirano, Masatsugu Nakano, Masahiro Yamawaki, Shinnya Sasaki
Journal: Journal of the American College of Cardiology (2011)
Suicide Among Doctors
Authors: J SPONAR, L PIVEC, Z SORMOVA
Journal: BMJ (1964)

PointersKveim Test: Dr. P. D'Arcy Hart and col- leagues suggest that positive reactions in clinically normal subjects who have failed to convert to B.C.G. indicate not occult sarcoidosis but some novel immunological change due to the vaccination (p.795).Leader discussing significance (p.791).Human Growth Hormone: Mr. W. M. Hunter and Dr. F. C. Greenwood report effects of tolbutamide, insulin, exercise, and oral glucose and protein on plasma levels of hormone (
Retraction Note to: The autoimmune regulator (Aire) controls iNKT cell development and maturation
Authors: Qing-Sheng Mi, Zhong-Bin Deng, Sunil K Joshi, Zai-Zhao Wang, Li Zhou, Sarah Eckenrode, Ratanmani Joshi, Dalam Ly, Bing Yi, Terry L Delovitch, Jin-Xiong She
Journal: Nature Medicine (2006)
Unusual cerebral inclusions in Reye's syndrome.
Authors: P L Lantos, P P Anthony, G R Clarke
Journal: BMJ (1976)

preceded the development of the classical clinical features of multiple sclerosis by almost four years. Case reportA 36-year-old man began to have paroxysmal attacks of dysarthria, ataxia, and weakness of his legs in February 1972.Each attack would last up to 10 seconds and he would experience at least a dozen such episodes each day.They would occur more frequently after a hot bath or any sudden exertion.In between his attacks he was free of symptoms and signs but during them he had bilateral horizontal nystagmus, dysarthria, and ataxia of his legs.In view of his unusual symptoms he was investigated in detail.Among the normal results of tests were cerebrospinal fluid, air encephalography, and four-vessel arteriography.Treatment with carbamazepine resulted in the complete cessation of his attacks.He was followed up at monthly intervals and eventually, in January 1976, developed numbness of both lower limbs and ataxia of gait.Examina- tion then disclosed bilateral horizontal nystagmus, cerebellar and pyramidal signs in all four limbs, with extensor plantar responses and absent abdominal reflexes.Examination of his cerebrospinal fluid then showed a protein of 0 45 g/l of which 23% was IgG.The Lange colloidal gold curve was 1232100000.
Repeated skin sampling and prolonged incubation period identified cutaneous <i> <scp>M</scp> ycobacterium chelonae </i> infection on the face in an immunocompetent man
Authors: K. Muramatsu, T. Nomura, T. Ito, Y. Hamade, Y. Hirata, Y. Fujita, R. Abe, H. Shimizu
Journal: British Journal of Dermatology (2013)

Journal Article Repeated skin sampling and prolonged incubation period identified cutaneous Mycobacterium chelonae infection on the face in an immunocompetent man Get access K. Muramatsu, K. Muramatsu Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan Search for other works by this author on: Oxford Academic Google Scholar T. Nomura, T. Nomura Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan Correspondence: Toshifumi Nomura. E‐mail: nomura@huhp.hokudai.ac.jp Search for other works by this author on: Oxford Academic Google Scholar T. Ito, T. Ito Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Hamade, Y. Hamade Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Hirata, Y. Hirata Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Fujita, Y. Fujita Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan Search for other works by this author on: Oxford Academic Google Scholar R. Abe, R. Abe Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan Search for other works by this author on: Oxford Academic Google Scholar H. Shimizu H. Shimizu Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 170, Issue 2, 1 February 2014, Pages 471–473, https://doi.org/10.1111/bjd.12638 Published: 01 February 2014
Abstract 3668: Single-dose activity of PSMA ADC against prostate cancer xenograft and explant tumors
Authors: Wells W. Magargal, William C. Olson
Journal: Cancer Research (2011)

Abstract Introduction: Prostate-specific membrane antigen (PSMA) is an attractive target for antibody-targeted therapy of prostate cancer due to its abundant and selective expression on the surface of prostate cancer cells. We have generated a novel antibody-drug conjugate (ADC) by linking a fully human PSMA monoclonal antibody to monomethylauristatin-E (MMAE), a potent tubulin inhibitor. Here, we describe the use of PSMA ADC to treat SCID mice bearing LNCaP xenografts or LuCaP explants derived from surgical resections of prostate cancer patients. Methods: PSMA expression in LNCaP and LuCaP tumor cells was evaluated by flow cytometry. Activity of PSMA ADC, assessed by decrease in tumor volume, was evaluated in LNCaP xenograft and LuCaP explant models. SCID mice were implanted subcutaneously with cultured LNCaP tumor cells or disaggregated human LuCaP 70 or LuCaP 77 prostate tumor tissue obtained from tumor-bearing mice. When average tumor size reached ∼300mm3, animals were randomized into groups of 9-10 mice and each animal was treated with a single intravenous dose of vehicle control, a control ADC of irrelevant specificity, or PSMA ADC. Treatment effects were assessed by measuring tumor volume and overall survival for up to 41 days post-treatment. Results: Surface expression of PSMA was assessed by flow cytometry, with a rank order of expression as follows: LNCaP &amp;gt; LuCaP 70, LuCaP 77, LuCaP 105 &amp;gt; LuCaP 96.1 &amp;gt; LuCaP 35V, LuCaP 141. Single-dose PSMA ADC demonstrated significant activity against LNCaP xenografts at a dose of 5 mg/kg (p&amp;lt;0.0001 relative to either vehicle or control ADC) and against LuCaP 77 explants at a dose of 10 mg/kg (p=0.0003 relative to either vehicle or control ADC). A trend toward delayed tumor growth was observed in the LuCaP 70 tumor model. Conclusion: Single-dose PSMA ADC showed activity against LNCaP xenografts and LuCaP explants derived from surgical resections of prostate cancer patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3668. doi:10.1158/1538-7445.AM2011-3668
STRUCTURAL ASPECTS OF HUMAN ERYTHROCYTE AUTOANTIBODIES
Authors: John P. Leddy, Richard F. Bakemeier
Journal: The Journal of Experimental Medicine (1965)

The 7S gamma-globulins causing erythrocyte autosensitization in 20 patients were isolated by elution and examined for homogeneity or heterogeneity of their L chain types and electrophoretic dispersion. The isolated erythrocyte autoantibodies from 12 patients contained only 1 detectable L chain type. Two of these "monotypic" populations showed appreciable restriction of electrophoretic dispersion, while 2 others more nearly resembled the electrophoretic heterogeneity of normal gamma-globulins. The autoantibodies from the other 8 patients exhibited L chains of both types. The single "bitypic" population so tested was relatively polydisperse electrophoretically. As a comparison, anti-Rh(o) isoantibodies from 5 of 6 donors without known hematologic disease showed bitypic reactions, and 2 of these isoantibody populations were relatively polydisperse electrophoretically. One Rh isoantibody is described which contained only 1 demonstrable L chain type. The structural similarities to "paraproteins" observed in a significant proportion of these erythrocyte autoantibodies raise the possibility of their origin from a restricted population of antibody forming cells, and may have implications concerning the pathogenesis of erythrocyte autosensitization.
Abstract A24: A possible role for GSK3β in epithelial ovarian cancer chemoresistance by epigenetic regulation
Authors: Noelle L. Cutter, Mena Yacoub, Robert D. Lucito, Nevenka Dimitrova, Elena Lum, Michael Vigliotti, Kazimierz Wrzeszczynski, Douglas A. Levine
Journal: Clinical Cancer Research (2013)

Abstract Ovarian cancers are highly heterogeneous and while chemotherapy is the preferred treatment many patients are intrinsically resistant or quickly develop resistance. Furthermore, all tumors that recur ultimately become resistant. Recent evidence suggests that epigenetic deregulation may be a key factor in the onset and maintenance of chemoresistance. We set out to identify epigenetically silenced genes that affect chemoresistance. The epigenomes of a total of 45 ovarian samples were analyzed to identify epigenetically altered genes that segregate with platinum response, and further filtered with expression data to identify genes that were suppressed. A tissue culture carboplatin resistance screen was utilized to functionally validate this set of candidate platinum resistance genes. Our screen correctly identified 19 genes that when suppressed altered the chemoresistance of the cells in culture. Of the genes identified in the screen we further characterized one gene, Glycogen Synthase Kinase 3 Beta (GSK3β), a proline-directed serine-threonine kinase, to determine if we could determine the mechanism by which it increased resistance. Preliminary results have indicated that the loss of GSK3b decreased the level of apoptosis in response to carboplatin. Furthermore, ovarian cell lines transcriptionally silenced for GSK3β are more invasive, have migratory ability, and display a transformed epithelial to mesenchymal (EMT) phenotype. Taken together, we provide the evidence of a role for GSK3β as an important epigenetic regulator of chemoresistance in ovarian cancer and hypothesize EMT as one of the underlying mechanisms. Citation Format: Noelle L. Cutter, Mena Yacoub, Robert D. Lucito, Nevenka Dimitrova, Elena Lum, Michael Vigliotti, Kazimierz Wrzeszczynski, Douglas A. Levine. A possible role for GSK3β in epithelial ovarian cancer chemoresistance by epigenetic regulation. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr A24.
Rivaroxaban Viable as Alternative Anticoagulant for Cardioversion
Authors: Anita Slomski
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Improving the Delivery of Radionuclides for Imaging and Therapy of Cancer Using Pretargeting Methods
Authors: Robert M. Sharkey, Habibe Karacay, Thomas M. Cardillo, Chien-Hsing Chang, William J. McBride, Edmund A. Rossi, Ivan D. Horak, David M. Goldenberg
Journal: Clinical Cancer Research (2005)

Abstract The article reviews the background and current status of pretargeting for cancer imaging and therapy with radionuclides. Pretargeting procedures were introduced ∼20 years ago as an alternative to directly radiolabeled antibodies. Because they were multistep processes, they were met with resistance but have since progressed to simple and improved procedures that could become the next generation of imaging and therapy with radionuclides. The separation of the radiolabeled compound from the antibody-targeting agent affords pretargeting procedures considerable flexibility in the radiolabeling process, providing opportunities for molecular imaging using γ- or positron-emitting radionuclides and a variety of β- and α-emitting radionuclides of therapeutic applications. Pretargeting methods improve tumor/nontumor ratios, exceeding that achieved with directly radiolabeled Fab′ fragments, particularly within just a few hours of the radionuclide injection. In addition, tumor uptake exceeds that of a Fab′ fragment by as much as 10-fold, giving pretargeting a greatly enhanced sensitivity for imaging. Advances in molecular biology have led to the development of novel binding proteins that have further improved radionuclide delivery in these systems. Studies in a variety of hematologic and solid tumor models have shown advantages of pretargeting compared with directly radiolabeled IgG for therapy, and there are several clinical studies under way that are also showing promising results. Thus, the next generation of targeting agents will likely employ pretargeting approaches to optimize radionuclide delivery for a wide range of applications.
The Psychology of Women: Ongoing Debate
Authors: Carol Nagy Jacklin
Journal: JAMA (1989)

One way to heighten our interest in and understanding of an issue is to state it in its most blatant form. This technique both clarifies the subject matter and helps us to articulate our own position on it. In<i>The Psychology of Women: Ongoing Debate</i>, this is exactly what editor, Mary Roth Walsh, has done. Walsh takes 14 questions in the area of psychology and gender and states them baldly. Questions include, "Are women masochistic?," "Is lesbianism a sickness?," "Should mothers stay home with their young children?," and "Does abortion cause psychological harm to women?" After some discussion on the formulation of each question and a useful reference list and suggestions for further reading by the editor, the affirmative and negative of each question are presented and generally eloquently argued by different scholars. The book is divided into four parts: "Psychoanalytic Theory and the Psychology of Women," "Femaleness and Psychological
SHORT-TERM WAITING LIST SURVIVAL WITHOUT SUPPORT BY A VENTRICULAR ASSIST DEVICE
Authors: Mark J. Russo, Jonathan Yang, Alexander Iribarne, Kimberly N. Hong, Hiroo Takayama, Ryan R. Davies, Allan S. Stewart, Jonathan M. Chen, Mathew Williams, Michael Argenziano, Yoshifumi Naka
Journal: Journal of the American College of Cardiology (2010)
Interface between university and medical school: the way ahead?
Authors: G. R D Catto
Journal: BMJ (2000)

Editorial by Goldbeck-Wood Education and debate pp 630, 636 

In the midst of the very public debate on health, the interface between university and medical school remains largely hidden. It is, however, an important influence not only on academic activity and resources but increasingly on commercial interests. The changing roles and responsibilities of medical schools affect many aspects of health, education, and regional development. The ways in which medical schools respond to different challenges should be understood if there is to be agreement on the opportunities and threats facing modern medical education.

#### Summary points

Medical education comprises a decreasing proportion of the workload of medical schools

Medical schools have close links with the health departments, but links with the funding councils and departments of education may be less robust, and funding streams are complex and poorly understood

Research interests of medical schools and their parent university may take precedence over teaching commitments and clinical duties

Curricular reform has been stimulated by the General Medical Council since graduation is linked to provisional GMC registration, and the public and profession must agree on standards expected at graduation

We all know what they are, but a succinct definition is now elusive. Of course, a medical school educates undergraduate medical students, but that role is decreasing as medical education moves with patients to the community and primary care. Indeed, colleagues in the NHS now undertake at least 70% of the clinical teaching and increasingly participate in planning the curriculum and assessment. Given the considerable diversity of arrangements adopted by different universities, the only other features medical schools have in common are a robust research base, clinical academic staff, and public interest. Many have substantial numbers of undergraduate and postgraduate students in disciplines other than medicine.

A medical school is an integral part of its parent …