Myopathy with Human Immunodeficiency Virus Type 1 (HIV-1) Infection: HIV-1 or Zidovudine?
Authors: Michele Till
Journal: Annals of Internal Medicine (1990)

Editorials1 October 1990Myopathy with Human Immunodeficiency Virus Type 1 (HIV-1) Infection: HIV-1 or Zidovudine?Michele Till, MD, Keith B. MacDonell, MDMichele Till, MD, Keith B. MacDonell, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-7-492 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent data indicate that early therapy with zidovudine is beneficial in slowing disease progression in persons infected with the human immunodeficiency virus type 1 (HIV-1) when CD4 cell counts are less than 500 cells/ mm3(1). Many persons infected with HIV-1 will be taking zidovudine over long periods, and clinicians may be faced with related complications. One such complication is the development of a drug-induced myopathy. Although muscle pathologies including inflammatory myopathy (2-5), type II atrophy (6), and nemaline rod myopathy (2, 7, 8) had been described in association with HIV-1 infection before use of zidovudine, there are now several...References1. FischlRichmanHansen MDN. The safety and efficacy of zidovudine (AZT) in the treatment of subjects with mildly symptomatic human immunodeficiency virus type 1 (HIV) infection. Ann Intern Med. 1990;112:727-37. LinkGoogle Scholar2. SimpsonBender DA. Human immunodeficiency virus-associ ated myopathy: analysis of 11 patients. Ann Neurol. 1988;24:79-84. CrossrefMedlineGoogle Scholar3. DalakasPezeshkpourGravellSever MGMJ. Polymyositis associated with AIDS retrovirus. JAMA. 1986;256:2381-3. CrossrefMedlineGoogle Scholar4. BaileyTurokJaufmannSingh RDBJ. Myositis and ac quired immunodeficiency syndrome. Hum Pathol. 1987;18:749-51. CrossrefMedlineGoogle Scholar5. BermanEspinozaDiaz ALJ. Rheumatic manifestations of human immunodeficiency virus infection. 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