tbuckley/cabot-search huggingface dataset:
Abstract 2333: Nuclear EPS8 as a potential cooperative factor for FOXM1 in cancer cell proliferation
Authors: Wan-Ling Ngan, Kwok-Ming Yao
Journal: Cancer Research (2014)

Abstract Tumorigenesis arises very often from dysregulated cell proliferation mechanisms. The Forkhead box transcription factor FOXM1 is a critical regulator of cell cycle progression as it affects the expression of genes that control the cell cycle, such as cyclin B1, cdc25B, etc. It is upregulated in various cancers, including cervical cancer. In a yeast two-hybrid screen for partnering factors that interact with FOXM1, we identified Epidermal Growth Factor Receptor (EGFR) Pathway Substrate 8 (EPS8). The involvement of EPS8 in the EGF signal transduction and actin cytoskeleton organization has been well documented. Despite the lack of an SH2 domain, EPS8 associates with the EGFR and is tyrosine-phosphorylated upon EGF signaling. With its level and phosphorylation strongly induced by serum stimulation, EPS8 is believed to partake in the regulation of cell proliferation. Based on recent observations that EPS8 and FOXM1 expression are both elevated in human cervical cancer cells, and expression levels of EPS8 and FOXM1 are correlated in human head and neck squamous cell carcinoma, we hypothesize that there is crosstalk between these two proteins in vivo to mediate cell cycle progression. In this study, interaction between FOXM1 and EPS8 was confirmed by co-immunoprecipitation analysis and the domains important for the interaction were defined using yeast two-hybrid assay. The presence of putative nuclear localization and export signals suggests regulation of EPS8 function by nucleocytoplasmic shuttling, consistent with EPS8 being a partnering factor of FOXM1 in the nucleus. Indeed, immunostaining of Hela cells revealed nuclear localization of EPS8 at S and G2/M phases of the cell cycle. Treatment with nuclear export inhibitor leptomycin B led to nuclear retention of EPS8, indicating that EPS8 localization is regulated by Crm-1-dependent nuclear export. Further site-directed mutagenesis defined nuclear export signals on EPS8 which affect the nuclear export/import of EPS8. Moreover, silencing EPS8 using shRNAs in various cell lines led to decreases in FOXM1 and cyclin B expression. Taken together, these data support that EPS8 may function together with FOXM1 in the nucleus and contribute to carcinogenesis via co-regulation of downstream target genes. Citation Format: Wan-Ling Ngan, Kwok-Ming Yao. Nuclear EPS8 as a potential cooperative factor for FOXM1 in cancer cell proliferation. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2333. doi:10.1158/1538-7445.AM2014-2333
NMDA Receptor Regulation Prevents Regression of Visual Cortical Function in the Absence of Mecp2
Authors: Severine Durand, Annarita Patrizi, Kathleen B. Quast, Lea Hachigian, Roman Pavlyuk, Alka Saxena, Piero Carninci, Takao K. Hensch, Michela Fagiolini
Journal: Neuron (2012)
Parathyroid Adenoma Localized in the Lower Neck in a Patient With Lingual Thyroid Demonstrated With TI-201/Tc-99m Pertechnetate Scintigraphy
Authors: RUTH HARDOFF, ELIZABETH BARON, MAXIM SHEINFELD
Journal: Clinical Nuclear Medicine (1995)

The authors describe a patient with a known lingual thyroid and hypothyroidism in whom hyperparathyroidism developed. A large parathyroid adenoma was detected using TI-201 scintigraphy, whereas ultrasonography and computerized tomography failed to detect the lesion. In this patient, the thyroid remained in its original embryonal site in the pharyngeal floor, while the parathyroid glands migrated normally to their final anatomical location. In adult life, both glands showed abnormal function: the thyroid gland was hypofunctioning, and the parathyroid gland was hyperfunctioning due to parathyroid adenoma. A lingual thyroid is often associated with hypothyroidism. However, the association of a parathyroid adenoma in a normally located parathyroid gland, with an ectopic thyroid is uncommon. TI-201/Tc-99m scintigraphy was able to distinguish between the different locations of the two structures and to establish the diagnosis.
Improving Population Health in US Cities
Authors: Nicholas W. Stine, Dave A. Chokshi, Marc N. Gourevitch
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Life threatening interaction between tamoxifen and warfarin.
Authors: P. Tenni, D. L. Lalich, M. J. Byrne
Journal: BMJ (1989)

A propos d'une observation: une malade traitee par warfarine presente un temps de prothrombine de 19 secondes. Apres addition au traitement de tamixifene, le temps passe aussitot a 38 secondes. Une etude retrospective montre d'autres cas: femmes traitees par tamoxifene et presentant des complications serieuses apres avoir recu en plus de la warfarine
College was right not to disclose deliberations about chronic fatigue treatment trial, tribunal rules
Authors: C. Dyer
Journal: BMJ (2013)

The UK Information Rights Tribunal has ruled that the University of London’s Queen Mary college was right not to disclose the discussions of research committees on a clinical trial of treatments for chronic fatigue syndrome (myalgic encephalomyelitis), in an important ruling concerning the importance of academic freedom.

The tribunal upheld the information commissioner’s decision that Queen Mary was entitled to withhold the minutes of meetings of the steering committee and management groups for the PACE (Pacing, Graded Activity, and Cognitive Behaviour Therapy—a Randomised Evaluation) trial, which looked at the effectiveness of treatments for chronic fatigue syndrome.

The £5m (€6m; $8m) trial, funded mainly by the Medical Research Council and led by Queen Mary, followed 641 patients, looking at the safety and efficacy of the various treatments available in the United …
An intervention involving pharmacist care via the Web improved blood pressure control in uncontrolled hypertension
Authors: Tejas V. Patel
Journal: Annals of Internal Medicine (2008)

Source Citation Green BB, Cook AJ, Ralston JD, et al. Effectiveness of home blood pressure monitoring, Web communication, and pharmacist care on hypertension control: a randomized controlled trial. JAMA. 2008;299:2857-67. 18577730
Changes in the law on drinking and driving.
Authors: J D Havard
Journal: BMJ (1983)

New legislation aimed at reducing the number of accidents caused by drinking drivers will take effect on 6 May.1 The extent to which drivers have been able to avoid conviction of the offence by relying on some technicality, or by taking deliberate steps to circumvent it, has been one of the most depressing aspects of our attempts to deal with the problem. The new law will go some way, but by no means all the way, to closing these loopholes. Drivers will no longer be able to avoid conviction for a section 5 offence (driving under the influence of drink or drugs) by running away from the vehicle, and the police will be able to enter any place where he has taken refuge if they have reason to believe that such an offence has been committed. The section 6 offence (driving  excess of the prescribed limit) has been extended to cover those who have been in charge or have been driving a vehicle. The suspect has a defence, however, if he can satisfy the court that he never intended to drive when he was in charge. The hip flask device?for example, deliberately drinking after an accident  order to make it impossible to determine accurately the concentration of alcohol at the time of the accident?has been dealt with  respect of both section 5 and section 6 offences. Not only will the suspect have to prove that he took alcohol after the incident and before providing a specimen, but the onus is placed on the driver to show that he would not have exceeded the prescribed limit (80 mg/100 ml) without the additional alcohol?thereby letting  the scientifically suspect practice of back calculation that is so widespread  European courts.
A memorable patient: Mother and child
Authors: I. Nesbitt
Journal: BMJ (2001)

She had walked for over a day, down from the jungle covered hills, and now lay stoically, silent and almost unblinking, watching us over the curve of her gravid abdomen. “Deep transverse arrest” meant nothing to me until I saw the baby's arm hanging limply between her legs. “You can deliver this one,” said the house officer in charge of the obstetric unit for the day.

I pulled the small, lifeless arm. It came off in my hand, neatly disarticulating at the shoulder blade like an overcooked chicken wing. There was a brief silence, and a kaleidoscope of emotion—embarrassment, horror, incredulity? I can't recall.

Predictably, inexorably, the situation became more technical, more invasive. An array of medieval instruments was tried, but served only to macerate the baby further. Under spinal anaesthesia, we removed the baby by caesarean section. I can still feel my fingers hooking through abdomen and lifting ribs out. I can still see the loose strings of green and black bowel being scooped out. I can't remember what we did with the assorted body parts, but I'm sure that the mother never saw her dead child. I have no idea what, if any, medical or psychological aftercare she received.

At the time, it was just another clinical experience garnered in the uncontrolled exotic world of Asian electives. The next week, a truckload of 50 wounded and dead was delivered to the hospital, fresh from a nearby border skirmish. For a while, I held the ace in the pack of clinical stories, a top trump of elective tales, more riveting than stories of golf in the Caribbean. With time, it faded away, tipped from the parapets of memory by the toil of house jobs and the steady accumulation of more immediate medical horror stories. But it never quite disappeared.

Now, more than a decade later, with children of my own and the experience of being an anxious parent in hospital behind me, I realise more of what this meant and reflect on how much I have changed in that time.

That woman deserved better than a newly qualified house officer and a foreign medical student to care for her. She deserved antenatal care, a decent transport system—all those things we take for granted in this part of the world. However, it wouldn't surprise me to find the situation unchanged, even in this new millennium. That saddens and troubles me still.
Remission of Proteinuria Following Correction of Hyperlipidemia in NIDDM Patients With Nondiabetic Glomerulopathy
Authors: Daniéle Dubois, Philippe Chanson, José Timsit, Dominique Chauveau, Dominique Nochy, Pierre-Jean Guillausseau, Jean Lubetzki
Journal: Diabetes Care (1994)

OBJECTIVE Animal studies suggest that hyperlipidemia may play a direct role in glomerular damage. In patients with non-insulin-dependent diabetes mellitus (NIDDM), dyslipidemia occurs early in the course of nephropathy and may be involved in the progression of renal disease. CASES We report on two young NIDDM patients with marked hyperlipidemia and proteinu ria, in whom renal biopsy demonstrated nondiabetic glomerulopathy. In both cases, the decrease in blood lipid levels was associated with a major decrease in proteinuria. Episodes of hyperlipidemia were associated with a resumption of heavy protcinuria in one patient with serum triglyceride levels and proteinuria being closely correlated. CONCLUSIONS These two cases suggest that hyperlipidemia has an important rolein the pathogenesis of glomerular disease.
Randomised trial of high doses of stilboestrol and ethisterone in pregnancy: long-term follow-up of mothers.
Authors: V Beral, L Colwell
Journal: BMJ (1980)

In 1950 a trial was set up to evaluate the effects of large doses of stilboestrol and ethisterone on rates of fetal loss in pregnant diabetic women. Eighty women were allocated at random to receive the hormonal treatment and 76 to receive inactive tablets of identical appearance. At follow-up 27 years later, information was obtained about 97% of the women, all but four being traced. All respondents were unaware of who had received hormones. The overall mortality was 4.5 times that of women of comparable age in England and Wales, most deaths being from complications of diabetes. More tumours, mainly benign, of the reproductive tract were reported in the hormone-exposed than the non-exposed group (14 (18%) and two (3%) respectively). Four cases of malignant breast disease were reported in the hormone-exposed women and none in the non-exposed. These findings support other evidence linking oestrogen treatment and breast cancer and suggesting that the latent period before the tumour becomes clinically apparent may be 15 years or longer.
38 RITONAVIR BOOSTING OF LOW DOSE RG7227/ITMN-191, HCV NS3/4A PROTEASE INHIBITOR, RESULTS IN ROBUST REDUCTION IN HCV RNA AT LOWER EXPOSURES THAN PROVIDED BY UNBOOSTED REGIMENS
Authors: E. Gane, R. Rouzier, C. Stedman, A. Wiercinska-Drapalo, A. Horban, L. Chang, Y. Zhang, P. Sampeur, I. Najera, N. Shulman, P. Smith, J. Tran
Journal: Journal of Hepatology (2010)
Preparing for National Health Insurance, and Other Matters
Authors: Daniel S. Greenberg
Journal: New England Journal of Medicine (1974)

Like generals setting up command posts in anticipation of a major campaign, Congress and the Administration have been collaborating on the creation of new institutions to govern the economics and administration of medicine when a national health-insurance plan is finally adopted. These creations, some already in place, and others still gestating, are a long way off from exerting the influence that has been carefully designed into them. But when the health-insurance plan comes into being — probably within the next year or so — it will be underpinned by a variety of federally inspired organizations that will have a profound . . .
Tension-Free Midurethral Slings in the Treatment of Female Stress Urinary Incontinence: A Systematic Review and Meta-analysis of Randomized Controlled Trials of Effectiveness
Authors: Giacomo Novara, Vincenzo Ficarra, Rafael Boscolo-Berto, Silvia Secco, Stefano Cavalleri, Walter Artibani
Journal: European Urology (2007)
Case 40-1963
Authors: Martin H. Wittenborg, Walter G. J. Putschar
Journal: New England Journal of Medicine (1963)

Presentation of CaseA twenty-year-old woman was admitted to the hospital because of pain in the knee.Three months previously, while in another hospital for a tonsillectomy, the patient had the onset of pain in the anterior portion of the left knee that was sufficiently severe to interfere with sleep. The pain was unrelated to motion of the leg, and x-ray films of the leg and knee taken at that time were interpreted as normal. Ten weeks before entry she experienced her customary intermenstrual discomfort, which was characterized by pain in the groin; the discomfort increased in severity, with radiation . . .
Sequential Computerized Axial Tomography in Tuberculous Meningitis
Authors: Dennis L. Stevens
Journal: JAMA (1978)

RECENT reports have stressed the value of computerized axial tomography (CAT) of the head in the evaluation of space occupying intracranial lesions including brain abscesses.<sup>2</sup>We recently treated a patient with tuberculous meningitis in whom CAT scanning showed two complications, tuberculoma formation and hydrocephalus. <h3>Report of a Case</h3> A 32-year-old man was admitted to the hospital on Feb 24, 1976, with a five-day history of headache and insomnia, followed by progressive lethargy and incoordination. A chest roentgenogram showed numerous nodular densities throughout both lungs, and a spinal fluid examination showed a polymorphonuclear leukocyte count of 6/cu mm. Findings of the remainder of the examination were normal, and ampicillin sodium and gentamicin sulfate therapy was started for presumed diazepam intoxication with aspiration pneumonia. Because of progressive deterioration of his clinical status, he was transferred to Brooke Army Medical Center on Feb 28, 1976, nine days after the onset of his
Impact of sunitinib pharmacokinetic monitoring in a patient with metastatic renal cell carcinoma undergoing hemodialysis
Authors: A. Thiery-Vuillemin, D. Montange, E. Kalbacher, T. Maurina, T. Nguyen, B. Royer, S. Bouchet, F. Bazan, E. Curtit, X. Pivot
Journal: Annals of Oncology (2011)
Purine derivatives in the study of allergic inflammation in respiratory diseases
Authors: Nunzio Crimi, Riccardo Polosa, Antonino Mistretta
Journal: Allergy (1997)

Adenosine, a naturally occurring purine nucleoside, elicits dose‐related bronchoconstriction in asthmatic subjects when administered by inhalation and it is recovered in increased amounts from the bronchial lavage fluid of subjects with active asthma when compared to normal controls. Although the mechanism by which adenosine mediates bronchoconstriction in asthmatic subjects is not clear, recent data indicate an important role for mast cell mediator release. We have recently shown that local airway challenge with adenosine in subjects with asthma and rhinitis provokes an increase in the levels of PGD2, histamine and tryptase. However, airway responsiveness and atopic status are the most important determinants of adenosine‐induced responses, regardless of any increases in mast cell mediators in airway fluids. New discoveries suggest that the airway response to adenosine may be an index of mast cell priming and therefore may provide a useful tool to further explore the inflammatory processes in allergic asthma and rhinitis. Therefore adenosine provocation may gain increasing acceptance as an additional measure of disease activity in asthma and rhinitis.
Stem Cell–Derived Organoids Are Functional in Vivo
Authors: Tracy Hampton
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Deliberate self harm in Sri Lanka: an overlooked tragedy in the developing world
Authors: M. Eddleston, M H R. Sheriff, K. Hawton
Journal: BMJ (1998)

The World Health Organisation's definition of health as “a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity” clearly relates social and mental wellbeing to physical health.1 For many years, however, attempts to improve health in the developing world concentrated on physical illness—mental health was relegated to the bottom of the list of priorities.2 Only recently has it begun to appear at the forefront of international public health.3

#### Summary points



Fig 1 
Bed occupancy in relation to diagnosis in the medical intensive care unit of Anuradhapura General Hospital, Sri Lanka, 1995-6



Sri Lanka has a high incidence of suicide—at least 40 suicides per 100 000 population each year compared with 8 per 100 000 in the United Kingdom. 4 5 As part of a collaboration between the universities of Colombo and Oxford, we have been studying new treatments for self poisoning in Anuradhapura General Hospital, a secondary referral centre for 900 000 people living in the North Central Province of Sri Lanka. Our work there has allowed us to observe at first hand the tragic consequences of these deaths for the families and the community.

During 1995 and 1996, 2559 adults (age range 12-73 years; 1443 men and 1116 women) were admitted to the …
Effect of ischemic preconditioning on interstitial purine metabolite and lactate accumulation during myocardial ischemia.
Authors: D G Van Wylen
Journal: Circulation (1994)

The purpose of this study was to determine the effect of ischemic preconditioning on the changes in interstitial fluid (ISF) purine metabolites and lactate during prolonged regional myocardial ischemia. The study consisted of two groups of anesthetized dogs: a control group (n = 13) that was exposed to 60 minutes of regional myocardial ischemia and a preconditioned group (n = 10). In the preconditioned group, regional myocardial ischemia was induced for two 5-minute episodes, each followed by 10 minutes of reperfusion. These preconditioning episodes were followed by 60 minutes of sustained regional ischemia. Cardiac ISF was sampled by microdialysis probes implanted in the left ventricular myocardium; dialysate levels served as indices of ISF concentrations. In the preconditioned group, dialysate concentrations of adenosine, inosine, hypoxanthine, total purines, and lactate increased during each of the 5-minute ischemia episodes, with further increases occurring during the first 5 minutes of reperfusion. However, the increases in dialysate purine metabolites during the first period of ischemia/reperfusion were greater than those that occurred during the second ischemia/reperfusion. In addition, preconditioning reduced the rate of ISF purine metabolite and lactate accumulation during the prolonged ischemia when compared with nonpreconditioned animals. These data suggest that preconditioning reduces the energy imbalance that occurs during subsequent myocardial ischemia and thereby diminishes the rate of net adenine nucleotide degradation and cellular production and release of purine metabolites and lactate. In addition, the increase in ISF adenosine seen during the preconditioning episode is consistent with the notion that preconditioning-induced cardioprotection is mediated in part by the action of adenosine at extracellular A1 adenosine receptors.