tbuckley/cabot-search huggingface dataset:
The Ethics Manual
Authors: JOHN F. CURRIN
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 December 1984The Ethics ManualJOHN F. CURRIN, M.D.JOHN F. CURRIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-6-873 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I write to take exception to the paragraph on abortion and contraception in the American College of Physicians Ethics Manual (1). This section states that a physician who has moral, religious, or ethical objections to abortion has "the duty to assure that the patient is provided the option of receiving competent medical advice and care from a qualified colleague who does not have these moral, religious, or ethical objections." There is also the standard caveat about a physician's not imposing his personal convictions on the patient.Does your ethics group feel that "pimping" an abortion makes one...Reference1. . American College of Physicians Ethics Manual. Part II: Research, other ethical issues, recommended reading. Ann Intern Med. 1984;101:263-74. LinkGoogle Scholar1. . American College of Physicians ethics manual: Part I. History of medical ethics, the physician and the patient, the physician's relationship to other physicians, the physician and society. Ann Intern Med. 1984;101:129-37. LinkGoogle Scholar2. . American College of Physicians ethics manual: Part II. Research, other ethical issues, recommended reading. Ann Intern Med. 1984; 101:263-74. LinkGoogle Scholar1. . American College of Physicians ethics manual: Part I. History of medical ethics, the physician and the patient, the physician's relationship to other physicians, the physician and society. Ann Intern Med. 1984;101:129-37. LinkGoogle Scholar2. . American College of Physicians ethics manual: Part II. Research, other ethical issues, recommended reading. Ann Intern Med. 1984;101:263-74. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Scottsdale Memorial Hospital Scottsdale, AZ 85251 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1984Volume 101, Issue 6Page: 873-874KeywordsContraceptives Issue Published: 1 December 1984 PDF DownloadLoading ...
Action of Different Bran Preparations on Colonic Function
Authors: W. O. Kirwan, A. N. Smith, A. A. McConnell, W. D. Mitchell, M. A. Eastwood
Journal: BMJ (1974)

Two different types of commercially available bran were studied. One of these was composed of flake-like particles (coarse bran) whereas the other had smaller, finer particles with a floury component (fine bran). The effectiveness of the two preparations in lowering intraluminal pressure and decreasing transit time in patients with constipation and diverticular disease was assessed. Only coarse bran promoted changes at the dose used. The physical properties of the brans were examined in an effort to explain their differing effects. It is concluded that water-holding capacity, upon which the beneficial effect of bran may depend, is a function of particle size. The greater water-holding capacity of coarse bran makes it preferable for the treatment of colonic disorders.
True Three-Dimensional Reconstructed Images Showing Lumen Enlargement After Sirolimus-Eluting Stent Implantation
Authors: Kengo Tanabe, Frank J.H. Gijsen, Muzaffer Degertekin, Jurgen M.R. Ligthart, Remko M. Oortman, Patrick W. Serruys, Cornelis J. Slager
Journal: Circulation (2002)
Understanding the health context to inform global health efforts
Authors: David A Tarantino
Journal: The Lancet Global Health (2014)

BackgroundEffective design and implementation of global health programmes requires a comprehensive and holistic understanding of the health circumstances of a given locality. At present, no widely accepted framework or construct for education and training in this specialty exists.MethodsAs part of a US Government research grant, the Center for Disaster and Humanitarian Assistance Medicine (CDHAM) at the Uniformed Services University did an analysis of existing and potential constructs for comprehensive understanding of health circumstances. Methods included a comprehensive literature review, a gap analysis, subject matter expert interviews, construct development exercise, and ongoing validation.FindingsCDHAM has developed a prototype framework for assessment and analysis of the health context of a given locality, including five essential domains: geopolitical/economic considerations; sociocultural considerations; health-specific cultural considerations; determinants of health; and health systems analysis. This framework is being taught in its general form at the Uniformed Services University and to personnel engaging in global health efforts. The health construct framework has also been applied specifically and in detail to Iraq and Afghanistan, yielding valuable insights regarding the health context, which are being used in training for personnel engaging in health efforts in these countries.InterpretationThe Health Context Construct for comprehensive and holistic understanding of the health circumstances of a given locality, developed by CDHAM, is showing promise as an instrument to inform and optimise the design and implementation of global health efforts. The Health Context Construct should be further validated and incorporated into global health curricula where appropriate.FundingDefense Language National Security Education Office (DLNSEO).
Cholesterol supplementation objectively reduces photosensitivity in the Smith-Lemli-Opitz syndrome
Authors: R.M. Azurdia, A.V. Anstey, L.E. Rhodes
Journal: British Journal of Dermatology (2001)

Journal Article Cholesterol supplementation objectively reduces photosensitivity in the Smith–Lemli–Opitz syndrome Get access R.M. Azurdia, R.M. Azurdia Photobiology Unit, Department of Dermatology, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, U.K., Search for other works by this author on: Oxford Academic Google Scholar A.V. Anstey, A.V. Anstey Photodermatology Unit, Department of Dermatology, University of Wales College of Medicine, Cardiff, U.K. Search for other works by this author on: Oxford Academic Google Scholar L.E. Rhodes L.E. Rhodes Photobiology Unit, Department of Dermatology, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, U.K., Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 144, Issue 1, 1 January 2001, Pages 143–145, https://doi.org/10.1046/j.1365-2133.2001.03964.x Published: 01 January 2001
Does This Patient Have Malaria?
Authors: Steve M. Taylor, Malcolm E. Molyneux, David L. Simel, Steven R. Meshnick, Jonathan J. Juliano
Journal: JAMA (2010)

Malaria commonly infects residents of and travelers to tropical regions. The clinical features of infection are notoriously nonspecific but have not been comprehensively evaluated.To systematically review and synthesize data related to the predictive value of clinical findings for the diagnosis of malaria in endemic areas and in travelers returning from endemic areas.The databases of MEDLINE and EMBASE (1950-July 2010) were searched to identify studies published in the English language of endemic and "imported" (acquired during travel) malaria. Additional studies were identified from reference lists. Studies were included that had patients suspected of having acute malaria (usually because of fever) and compared the presence or absence of clinical findings with blood smear confirmation. Two authors independently identified studies, appraised study quality, and extracted data on the patient population, outcome assessment, and clinical findings. Differences between reviewers were resolved by consensus.Fourteen studies for endemic malaria were identified that met review criteria. Individual symptoms are of limited diagnostic utility but presence of splenomegaly (summary likelihood ratio [LR], 3.3; 95% confidence interval [CI], 2.0-4.7) or hepatomegaly (summary LR, 2.4; 95% CI, 1.6-3.6) make malaria more likely. Combinations of findings can affect the likelihood of malaria, but their performance varies by setting. Seven studies of imported malaria were identified. The presence of fever (LR, 5.1; 95% CI, 4.9-5.3), splenomegaly (summary LR, 6.5; 95% CI, 3.9-11.0), hyperbilirubinemia (LR, 7.3; 95% CI, 5.5-9.6), or thrombocytopenia (summary LR, 5.6; 95% CI, 4.1-7.5) make malaria more likely.In endemic areas, the likelihood of malaria is increased by the presence of splenomegaly and hepatomegaly but individual findings are of limited utility and cannot reliably exclude malaria; combinations of findings may be useful to stratify risk in patients. In returning travelers, the clinical assessment can provide substantial diagnostic benefit, although all patients still require laboratory testing because malaria can be rapidly fatal.
Impaired oxidation of debrisoquine in patients with perhexiline neuropathy.
Authors: R R Shah, N S Oates, J R Idle, R L Smith, J D Lockhart
Journal: BMJ (1982)

The use of perhexiline maleate as an antianginal agent is occasionally associated with side effects, particularly neuropathy and liver damage. The reason why some individuals develop these toxic reactions is not clear, though some evidence suggests that they may result from impaired oxidative metabolism, due to genetic or hepatic factors, and consequential accumulation of the drug in toxic concentrations. Drug oxidation was measured with an oxidation phenotyping procedure in 34 patients treated with perhexiline, 20 of whom had developed neuropathy and 14 of whom had not. Most of the 20 patients with neuropathy, but not the unaffected patients, showed an impaired ability to effect metabolic drug oxidation. This impairment was independent of hepatic function, concurrent drug therapy, or tobacco or alcohol consumption. The fact that the ability to oxidise several drugs is genetically controlled points to a genetic susceptibility to developing neuropathy in response to perhexiline. Routine determination of the drug oxidation phenotype might lead to safer use of perhexiline by predicting patients who may be more at risk of developing a neuropathic reaction associated with its long-term use.
Rat catcher's warfarin treatment associated with rectal haemorrhage.
Authors: R. M. Kirby, L. J. Lawson
Journal: BMJ (1988)

Allergic reaction to prick tests with fruitjuiceTest substanceReaction at 20 minutes Mango juice 2-7 cm Wheal with 5 2 cm spur and surrounding erythema 1:10 Mango:physiological saline 2-0 cm Wheal Melon juice 0-8 cm Wheal Physiological salineNo reaction
Dynamic 3-dimensional echocardiographic reconstruction of the left ventricle using color doppler myocardial tissue imaging technique. In vivo experimental and clinical study
Authors: José Azevedo, Miguel Garcia-Fernandez, Pablo Puerta, Mar Moreno, Daniel SanRoman, Esteban Torrecilla, Esteban Lopez de Sa, Jose Vallejo, Juan Luis Delcan
Journal: Journal of the American College of Cardiology (1996)
Nephrosis Due to Mercurial Diuretics
Authors: J. Burston, E. M. Darmady, F. Stranack
Journal: BMJ (1958)

Middlesex had its record lowest infant mortality rate in 1957.There were 561 deaths of infants under 1 year old, giving a rate of 17.7 per thousand live births.This is 5.3 below the rate for England and Wales as a whole.As else- where, deaths from lung cancer increased, being 1,166, or 76 more than in 1956.Despite an excess of live births over deaths amounting to more than 9,000, the population of the county again fell owing to removal from it.At about 2km. the population was 2,000 lower than in 1956.
"HEMOLYSIS FOLLOWING TRANSFUSION"
Authors: P. C. West
Journal: JAMA (1922)

<h3>To the Editor:</h3> —After reading the article by Dr. P. S. Astrowe on "Hemolysis Following Transfusion" (The Journal, Oct. 28, 1922, p. 1511), I referred to my notes written before the war. They disclosed that I had performed agglutination and hemolysis tests similar to if not exactly the same as those described. The only difference was that the hemolysis test was left in the icebox over night. There was no agglutination and no hemolysis. After the transfusion, when the performance of a second transfusion was considered, the surgeon asked me again to test out the previous donor and recipient, both of whom were adults: This was done and there was no agglutination, but the recipient's serum hemolyzed the donor's cells. Because of the positive statements made by men in the conservative East, no mention was made except to the surgeon, who did not do the second transfusion. Under "Transfusion of
A Manual of Practical Anatomy.
Authors: Daniel John Cunningham
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid and Its Derivatives Elicit Human Lymphoid Cell Apoptosis through a Novel Pathway Involving the Unregulated Mitochondrial Permeability Transition Pore
Authors: Paul S. Brookes, Kimberly Morse, Denise Ray, Andrew Tompkins, Sara M. Young, Shannon Hilchey, Suhail Salim, Marina Konopleva, Michael Andreeff, Richard Phipps, Steven H. Bernstein
Journal: Cancer Research (2007)

Abstract 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) and its C28 imidazole and dinitrile derivatives are novel oleanane triterpenoids exhibiting promise as both therapeutic and preventative agents for cancer. Herein we show that these triterpenoids induce normal and malignant B-lymphoid cell apoptosis, with the C28 derivatives being more potent than CDDO, through a novel mitochondrial mechanism. We show using both normal and malignant human B cells, as well as isolated rat mitochondria, that CDDO directly interacts with a limited number of as yet undefined mitochondrial proteins. Such an interaction results in the loss of mitochondrial thiol status and the secondary modification of numerous mitochondrial protein thiols. Our data further suggest that such modifications result in the formation of high molecular weight protein aggregates that form “unregulated,” constitutively open, cyclosporin A–insensitive permeability transition (PT) pores. The formation of such PT pores results in the subsequent generation of mitochondrial superoxide and cell death. In total, our studies (a) suggest a novel mechanism of action for triterpenoid-induced cell death; (b) are among the first to directly support the existence of an unregulated PT pore formed by mitochondrial protein aggregates, as first proposed by Lemasters and colleagues; and (c) validate such an unregulated PT pore as a viable target for the development of new cancer therapeutics. [Cancer Res 2007;67(4):1793–802]
Bivalirudin provides increasing benefit with declining renal function in percutaneous coronary intervention: A meta-analysis of 5,035 patients enrolled in three randomized trials
Authors: Derek P. Chew, Deepak L. Bhatt, Peter B. Berger, Tim Henry, Peter A. McCullough, Frederick Feit, John A. Bittl, A. Michael Lincoff
Journal: Journal of the American College of Cardiology (2003)
CAPILLARY BLOOD PRESSURE IN MAN. DIRECT MEASUREMENTS IN THE DIGITS OF NORMAL AND HYPERTENSIVE SUBJECTS DURING VASOCONSTRICTION AND VASODILATATION VARIOUSLY INDUCED 12
Authors: Ludwig W. Eichna, James Bordley
Journal: Journal of Clinical Investigation (1942)

TABLE I Capilary blood pressure during two series of measurements in the same location of the same capillary during a single experimnt Location Capillary blood pressure Subject Diag.oobSidn tem- Arterial where capillary Interval be- (Sub age) O perature presure blood pressre tween readings was measured First series Second sies Difference °C.mm.Hg minuAs mm.
The Effect of Hospital Financial Characteristics on Quality of Care
Authors: Helen R. Burstin
Journal: JAMA (1993)

<h3>Objective.</h3> —To assess the relationship among hospital financial characteristics, patient payer mix, and the incidence of negligent medical injuries. <h3>Design.</h3> —Retrospective medical record review linked to hospital financial reports. <h3>Setting.</h3> —Acute care hospitals in New York State in 1984. <h3>Population.</h3> —Stratified, random sample of 30195 medical records from 51 acute care hospitals. <h3>Main Outcome Measures.</h3> —Hospital rates of medical injury and substandard care were developed from reviews of 30195 medical records at 51 acute care hospitals in New York in 1984. Hospital-level variables representing financial status, hospital staffing, and the proportion of self-pay and Medicaid hospital discharges were compiled from a variety of secondary sources. <h3>Results.</h3> —The likelihood of negligent medical injury was highest in those hospitals with the lowest inpatient operating costs per hospital discharge (odds ratio, 2.8; 95% confidence interval, 1.5 to 5.5). The effect of low inpatient operating costs was marked among hospitals in financial distress, many of which served indigent populations. <h3>Conclusions.</h3> —Patients admitted to hospitals that are unable to expend sufficient resources on patient care may be at higher risk of substandard care. Further study of the effect of hospital financial status on quality of care appears to be warranted. (<i>JAMA</i>. 1993;270:845-849)
The William C. Menninger Memorial Lecture: Some Psychobiological Determinants of Somatic Disease.
Authors: George L. Engel
Journal: Annals of Internal Medicine (1968)

s1 May 1968The William C. Menninger Memorial Lecture: Some Psychobiological Determinants of Somatic Disease.George L. Engel, M.D.George L. Engel, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1140_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOne of the most firmly held folk notions has been that despair, gloom, grief, loneliness, misfortune, and the like predispose to disease, while faith, confidence, tranquility, and peace of mind aid recovery and insure health. One discovers such themes repeatedly in the myths, legends, folklore, and literature of all peoples. Physicians, too, have held such beliefs, particularly in the romantic era of the nineteenth century, just before the flowering of modern scientific medicine. Even in modern times physicians grudgingly acknowledge from time to time that they have encountered instances in which such influences seem to have been prepotent. Yet among... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: George L. Engel, M.D.Affiliations: Rochester, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1140-1140 ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...
Spain regulates access to unhealthy foods in schools
Authors: A. G. Rada
Journal: BMJ (2010)

Authorities in Spain have agreed a policy to limit the availability of junk food in public school canteens and vending machines in a bid to promote healthy eating and tackle the growing rates of overweight and obesity among children.

Trinidad Jimenez, Spain’s minister for health and social policy, and all 17 autonomous communities agreed the policy at the Interterritorial Council of the National Health Service, the body that meets regularly to coordinate state and regional actions in matters of health.

The agreement will establish criteria for developing …
The effect of electrochemically simulated titanium cathodic corrosion products on ROS production and metabolic activity of osteoblasts and monocytes/macrophages
Authors: Marie Kalbacova, Sophie Roessler, Ute Hempel, Roman Tsaryk, Kirsten Peters, Dieter Scharnweber, James C. Kirkpatrick, Peter Dieter
Journal: Biomaterials (2007)
SODIUM THIOCYANATE (RHODANATE) AND THE THEORY OF AGGLOMERATION
Authors: Chauncey D. Leake
Journal: JAMA (1933)

ABSTRACT To the Editor: —A timely editorial comment in The Journal, Dec. 31, 1932, page 2270, calls attention to the extraordinary advertising and clinical activities of Prof. Wilder D. Bancroft of Cornell University. It is unfortunate that the comment did not go on to indicate the equally extraordinary character of Professor Bancroft's alleged scientific investigations into the colloid chemistry of anesthesia, disinfection, sleep, the central nervous system, insanity, drug addiction, and many other difficult medical propositions—such as anaphylaxis and strychnine poisoning. These publications by Professor Bancroft and his pupils have appeared since 1930 in the Proceedings of the National Academy of Science (of which Professor Bancroft has long been a member) and the Journal of Physical Chemistry (which Professor Bancroft founded and edited), and of course they have been prominently featured by the public press.Perusal of these many papers reveals a number of remarkable features common to them all: (1)
Chemoradiotherapy with taxane is superior to conventional surgery and radiotherapy in the management of cutaneous angiosarcoma: a multicentre, retrospective study
Authors: Y. Fujisawa, K. Yoshino, T. Kadono, T. Miyagawa, Y. Nakamura, M. Fujimoto
Journal: British Journal of Dermatology (2014)

The prognosis of cutaneous angiosarcoma (CAS), especially for patients with tumours > 5 cm has been reported to be dismal, even after conventional surgery and radiotherapy (S + RT).To demonstrate the efficacy of chemoradiotherapy with taxane (T + RT) and maintenance chemotherapy.We retrospectively reviewed 16 patients with CAS treated with T + RT and 12 patients treated with S + RT. None had distant metastasis. Tumour sites included the scalp (n = 25) and limbs (n = 3). The chemotherapy regimens used in T + RT were monthly docetaxel (n = 10), biweekly docetaxel (n = 1), weekly docetaxel (n = 5) and weekly paclitaxel (n = 1). The median radiation dose was 70 Gy. Nine patients receiving T + RT continued chemotherapy as maintenance therapy (monthly docetaxel in nine patients and monthly paclitaxel in two patients) and four patients receiving S + RT received adjuvant chemotherapy (weekly docetaxel).The response ratio of T + RT was 94% (14 complete remission and one partial remission). The 5-year overall survival (OS) rate of patients receiving T + RT was statistically higher than those receiving conventional S + RT (56% and 8%, respectively; P < 0·01). Moreover, patients who received T + RT with maintenance chemotherapy showed a significant improvement in OS than those receiving T + RT alone (P < 0·01). There was a strong trend for relapse-free survival, but it was not significant (P = 0·07). These data indicate that maintenance chemotherapy is crucial for long-term survival after T + RT.From these results, we suggest that T + RT followed by maintenance chemotherapy is a plausible method for managing CAS, especially large tumours that are difficult to manage with S + RT alone.