tbuckley/cabot-search huggingface dataset:
Romance, Poetry, and Surgical Sleep: Literature Influences Medicine
Authors: E. S. Siker
Journal: JAMA (1996)

This work reminds us of medicine's many roots in literature, anesthesia included. The primary question addressed by the author, simply stated, is: the discovery of anesthesia—what took so long!? If sentient humankind is decent and compassionate, if surgery prior to anesthesia was an unendurable torture, why weren't means of allaying such suffering sought long before the 1840s? (In 1841, Crawford Long first used ether as an anesthetic but failed to report the event. On October 16,1846, William Morton gave the first public demonstration of ether anesthesia.) Dr Emanuel Papper proposes an answer early in<i>Romance, Poetry, and Surgical Sleep</i>: "It took so long to discover 'anesthesia' because there was no societal readiness for it nor interest in the prevention of the pain of surgical intervention or really in the relief of pain for the common man until the idea that humankind had a right 'to pursue happiness'." He further proposes
A Contribution to the Study of Chloralamide
Authors: J. Gordon
Journal: BMJ (1891)

of contact withl an ordinary solid determines the mutual re- actioni of the corl)uscles anid the liquor sanguinis.Yet no coagulation occurs as the resuilt of suchl an operation.It is, I plresume, in the capillary system that the correctingC influlence is exerted.Again whlen inti!lise iniflanimatory congestion is produced by the application of some irritant substance to the web of a frog's foot., we see that the corpuscles, both red and white, adlhere to onie anotlher and to the walls of the vessels, and block the capillaries.Mechanical violence is one of the many irritatinlg agencies which produce such congestion;
Treatment of graft‐versus‐host disease in human allogeneic marrow graft recipients: A randomized trial comparing antithymocyte globulin and corticosteroids
Authors: K. C. Doney, P. L. Weiden, R. Storb, E. D. Thomas
Journal: American Journal of Hematology (1981)

Abstract This prospective randomized trial compared the effect of antihuman thymocyte globulin (ATG) versus corticosteroids as treatment of graft‐versus‐host disease (GVHD) in recipients of HLA‐identical allogeneic bone marrow transplants. Patients undergoing transplantation as therapy for either hematologic malignancies or aplastic anemia were given methotrexate as postgrafting immunosuppression. Patients who nevertheless developed acute GVHD of moderate severity were randomized to receive either corticosteroid therapy or ATG therapy. Thirty‐seven patients were randomized: 20 patients received corticosteroids, and 17 received ATG. Both ATG and corticosteroids were in general well tolerated, although all patients receiving ATG developed fever and chills. Both treatment modalities were associated with a mild decrease in severity of GVHD after therapy. There was, however, no significant difference between treatment groups, whether assessed by improvement in specific organ involvement, improvement in the overall grade of GVHD, need for additional therapy for acute GVHD, or the proportion of patients who developed chronic GVHD. Infectious complications and survival were also not different between treatment groups. Thus, corticosteroids were as effective as ATG for the treatment of acute GVHD in recipients of HLA‐identical marrow transplants and, therefore, appear to be a reasonable choice as primary therapy for acute GVHD.
Is monkeypox a reservoir of smallpox?
Authors: Z. Danilevicius
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ipecac Intoxication — Use of a Cardiac Pacemaker in Management
Authors: Jane MacLeod
Journal: New England Journal of Medicine (1963)

SYRUP of ipecac is widely used to induce emesis in children who have ingested toxic substances. The occurrence of vomiting serves to protect against overdosage of the ipecac syrup. However, if emesis fails to occur the ipecac will be absorbed, and its toxic effects thereby added to those of the toxin for which it is given. The following case is reported to illustrate the failure of emesis when syrup of ipecac was given after ingestion of an antiemetic, and to call attention to the risk of cardiac irregularities and the danger of cardiac arrest with ipecac and the prophylactic use . . .
The health consequences of the first Gulf war
Authors: D. Clauw
Journal: BMJ (2003)

The lessons are general (and for many patients) rather than specific to that war 

Two papers in this issue of the BMJ describe the long term health of British veterans of the 1990-1 Gulf war. In the article by Hotopf et al the King's Gulf war illnesses research group present another excellent study, this one indicating that 11 years after the conflict the Gulf veterans continue to experience considerably poorer health than control groups (p 1370).1 The article by Macfarlane et al examines the rate of malignancy in Gulf war veterans and shows that their overall rate of cancer is almost identical to those not deployed, even among those reporting exposure to potentially carcinogenic factors such as depleted uranium or pesticides (p 1373).2 These results are congruent with other data collected in both UK and US Gulf war veterans. Twelve years after the war, and after roughly $300m (£174m;€250m) has been spent on research, what do we know about the health of Gulf war veterans, in relation to what has actually happened to them?

Firstly, there is no evidence of excess malignancy, birth defects, or increased mortality associated with Gulf war deployment. However, and secondly, when those sent to the Gulf war are compared with military veterans of the same era who were not …
Sexual Exploitation of Patients by Health Professionals
Authors: Dorothy M. Bernstein
Journal: JAMA (1987)

In our culture, the physician is entrusted with complete access to the patient's self, both mental and physical. Other health professionals may have limited privileges, eg, psychotherapists who deal with mental health. Society grants such an unlimited approach by recognizing these groups as professionals in the sphere of health care. Medicine gained this right during its professionalization, when it acquired institutional attributes recognized by society as sufficient for a profession and was granted autonomy in its function. One of medicine's necessary qualifications is its code of ethics, chief of which is to serve the patient and do no harm. Sexual contact between physician and patient explicitly lies within this arena. It has been forbidden as far back as ancient medicine, exemplified in the Hippocratic Oath, and as recently as today, delineated in the codes of the American Psychiatric Association. This book deals with sexual exploitation of patients, long existing if
Oxidation of pristanic acid in fibroblasts and its application to the diagnosis of peroxisomal beta-oxidation defects.
Authors: B C Paton, P C Sharp, D I Crane, A Poulos
Journal: Journal of Clinical Investigation (1996)

Pristanic acid oxidation measurements proved a reliable tool for assessing complementation in fused heterokaryons from patients with peroxisomal biogenesis defects. We, therefore, used this method to determine the complementation groups of patients with isolated defects in peroxisomal beta-oxidation. The rate of oxidation of pristanic acid was reduced in affected cell lines from all of the families with inherited defects in peroxisomal beta-oxidation, thus excluding the possibility of a defective acyl CoA oxidase. Complementation analyses indicated that all of the patients belonged to the same complementation group, which corresponded to cell lines with bifunctional protein defects. Phytanic acid oxidation was reduced in fibroblasts from some, but not all, of the patients. Plasma samples were still available from six of the patients. The ratio of pristanic acid to phytanic acid was elevated in all of these samples, as were the levels of saturated very long chain fatty acids (VLCFA). However, the levels of bile acid intermediates, polyenoic VLCFA, and docosahexaenoic acid were abnormal in only some of the samples. Pristanic acid oxidation measurements were helpful in a prenatal assessment for one of the families where previous experience had shown that cellular VLCFA levels were not consistently elevated in affected individuals.
Microscopic polyangiitis. A systemic vasculitis with a positive P-ANCA
Authors: P. F. PEÑAS, J. I. PORRAS, J. FRAGA, C. BERNIS, C. SARRIÃ, E. DAUDÉN
Journal: British Journal of Dermatology (1996)

A young girl presented with a purpuric rash on lower limbs, fever, eosinophilia, peripheral neuropathy and progressive renal insufficiency. She developed vesicles, purpuric macules and papules on the head, several nodules on the palmar sides of hands and fingers, splinter haemorrhages, and a disfiguring, facial oedema. A renal biopsy specimen disclosed a focal and segmental necrotizing glomerulonephritis with crescents. Peripheral ANCA with antimyeloperoxidase specificity [P-ANCA (MPO)] was positive and cytoplasmic ANCA with PR3 specificity was negative. Treatment with prednisone and cyclophosphamide was started with a good clinical response, stabilization of renal insufficiency and disappearance of P-ANCA (MPO). Our case fulfils the diagnostic criteria for microscopic polyangiitis (microscopic polyarteritis, MPA), namely a segmental necrotizing and crescentic glomerulonephritis associated with extrarenal vasculitis involving small-sized vessels, without granulomas or asthma. This is a rare disease, which has a poor prognosis in the absence of aggressive therapy, and is infrequently reported in dermatological journals.
Pulmonary Congestion of Noncardiac Cause as a Feature of the "Shock Lung" Syndrome.
Authors: Leon Stein
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Pulmonary Congestion of Noncardiac Cause as a Feature of the "Shock Lung" Syndrome.Leon Stein, M.D., Jose M. Cavanilles, M.D., Max Harry Weil, M.D., F.A.C.P., Herbert Shubin, M.D., F.A.C.P.Leon Stein, M.D.Search for more papers by this author, Jose M. Cavanilles, M.D.Search for more papers by this author, Max Harry Weil, M.D., F.A.C.P.Search for more papers by this author, Herbert Shubin, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-868_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPulmonary congestion or edema during volume loading may be caused by factors other than left ventricular failure. The present studies were based on measurements obtained on four critically ill patients who presented with clinical and hemodynamic signs of hypovolemia and shock. None of the patients had evidence of prior heart disease. Initial chest X rays showed clear lung fields. Pulmonary artery end-diastolic or wedged pulmonary artery pressures were in the normal range and averaged 10 mm Hg. After infusion of large volumes of fluid, unequivocal clinical and radiographic evidence of pulmonary congestion or edema, or both, appeared. Heart size and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 868-868KeywordsAcute respiratory distress syndromeCardiovascular therapyEdemaHeartHemodynamicsLungsPulmonary arteriesShockThorax Issue Published: 1 May 1972 PDF downloadLoading ...
Relation between the bronchial obstructive response to inhaled lipopolysaccharide and bronchial responsiveness to histamine.
Authors: O Michel, R Ginanni, R Sergysels
Journal: Thorax (1992)

BACKGROUND: Bronchoconstriction has developed after inhalation of lipopolysaccharide in a dose of 20 micrograms in asthmatic patients and of 200 micrograms in normal subjects. This study set out to determine whether the bronchial response to lipopolysaccharide was related to non-specific bronchial responsiveness and atopy. METHODS: Sixteen subjects with a fall in specific airway conductance of 40% (PD40sGaw) after inhaling up to 900 micrograms histamine inhaled 20 micrograms lipopolysaccharide (from Escherichia coli type 026:B6) a week after bronchial challenge with a control solution of saline. The bronchial response over five hours was measured as change in FEV1 and area under the FEV1-time curve. RESULTS: FEV1 fell significantly more after lipopolysaccharide than after diluent inhalation, the difference in mean (SE) FEV1 being 4.6% (5.4%); response was maximal 60 minutes after lipopolysaccharide inhalation and lasted more than five hours. Histamine PD20FEV1 and PD40sGaw correlated with the fall in FEV1 after lipopolysaccharide inhalation. There was no difference in the proportions of responders and non-responders to lipopolysaccharide who were atopic. CONCLUSION: Lipopolysaccharide induced bronchial obstruction is associated with non-specific responsiveness but not with atopy.
Shock Wave Therapy for Treatment of Plantar Fasciitis
Authors: Steven Miller
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Feasibility and Effectiveness of Peripheral Percutaneous Transluminal Balloon Angioplasty in Diabetic Subjects With Foot Ulcers
Authors: Ezio Faglia, Fabrizio Favales, Anthonella Quarantiello, Patrizia Calia, Giorgio Brambilla, Antonio Rampoldi, Alberto Morabito
Journal: Diabetes Care (1996)

OBJECTIVE The aim of this study was to evaluate the feasibility and effectiveness of this vascular procedure in diabetic inpatients with foot ulcers. RESEARCH DESIGN AND METHODS In 80 consecutive inpatient diabetic subjects with a foot ulcer, an angiographic study of the lower limbs was carried out to evaluate the necessity and possibility of performing vascular procedures. In 22 subjects, vascular procedure was not necessary; in 26 subjects, peripheral transluminal angioplasty was carried out; in 10 subjects, angioplasty was considered impossible and a peripheral bypass graft was performed; and in 22 subjects, no vascular procedure was considered possible. RESULTS Of the 26 angioplasties, 8 were performed in iliac or femoral arteries and 18 were performed in the popliteal artery and its branches. The angioplasty was considered unsuccessful in 4 subjects and successful in 22. After angioplasty, on discharge, parameters of limb perfusion improved significantly: transcutaneous oxygen tension was 27.0 ± 14 mm/Hg on admission and 44.6 ± 14 mm/Hg on discharge (P &amp;lt; 0.001); ankle-brachial index was 0.61 ± 0.23 on admission and 0.77 ± 0.20 on discharge (P = 0.018). Of 22 subjects who underwent successful angioplasty, 21 ended the follow-up of 12 months: during this period, they showed no relapses in the salvaged limb, and their parameters of limb perfusion did not significantly vary. CONCLUSIONS Angioplasty is feasible in a large percentage of diabetic subjects with peripheral occlusive arterial disease and foot ulcer and is often also practicable in the popliteal artery and its branches. In these subjects, angioplasty significantly improves the parameters of limb perfusion. Angioplasty is therefore an important therapeutic tool in ulcerated diabetic foot care.
Vascular Formations of the Lip and Peptic Ulcer
Authors: John A. Gius, Don E. Boyle, Donald D. Castle, Ralph H. Congdon
Journal: JAMA (1963)

Certain tiny formations of the lip vessels called "microcherry," "glomerulus," and "venous lake" have been studied in 427 patients. Among the 427 there were 101 patients who had peptic ulcer or a history of ulcer. The studies indicate that these vascular formations increased with age and are more common in males than in females. Patients with ulcer, however, showed vascular formations earlier in life and in greater number than did controls without ulcer. These observations suggest that vascular formations are correlated with the ulcer diathesis. This lends support to the hypothesis that a vascular substrate which is derived genetically or environmentally, or both, predisposes the individual to gastroduodenal ulcer.
Tuberculosis After Gastrointestinal Surgery
Authors: JEFFREY R. FISHER
Journal: Annals of Internal Medicine (1977)

Letters and Corrections1 December 1977Tuberculosis After Gastrointestinal SurgeryJEFFREY R. FISHER, M.D.JEFFREY R. FISHER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-6-792_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Gastrectomy is one of several conditions associated with an increased risk of developing tuberculosis. The American Thoracic Society currently recommends isoniazid prophylaxis for persons with positive tuberculin skin tests who have had gastrectomy (1). The evidence supporting this recommendation has been reviewed elsewhere (2). More recently, tuberculosis has been reported after jejunoileal bypass surgery for obesity (3-5). During the past year, we have seen two patients who developed tuberculosis after upper gastrointestinal surgery without gastrectomy or jejunoileal bypass. Neither patient had contact with a known active case.A 57-year-old diabetic man with a positive tuberculin reaction (12...References1. : Preventive therapy of tuberculous infection. Am Rev Respir Dis 110:371-374, 1974 MedlineGoogle Scholar2. BEFELERBAUM BG: Active pulmonary tuberculosis after upper gastrointestinal surgery. Am Rev Respir Dis 96:977-980, 1967 MedlineGoogle Scholar3. PICKLEMANEVANSKANEFREEARK JLJR: Tuberculosis after jejunoileal bypass for obesity. JAMA 234:744, 1975 CrossrefMedlineGoogle Scholar4. BATTERSHILL J: Tuberculosis after intestinal bypass surgery for obesity (letter). Chest 70:318, 1976 CrossrefMedlineGoogle Scholar5. HARRISWASSON JK: Tuberculosis after intestinal bypass operation for obesity. Ann Intern Med 86:115-116, 1977 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1977Volume 87, Issue 6Page: 792-792KeywordsGastrectomyIsoniazidObesityProphylaxisSkin testsSurgeryTuberculin Issue Published: 1 December 1977 PDF DownloadLoading ...
Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation
Authors: Yanan Cao, Ying Xue, Lu Xue, Xiuli Jiang, Xiaolin Wang, Zhijian Zhang, Jian Yang, Jieli Lu, Changxian Zhang, Weiqing Wang, Guang Ning
Journal: Journal of Hepatology (2013)
Letters: Omeprazole and Vitamin B_12
Authors: Stefan P. Marcuard
Journal: Annals of Internal Medicine (1994)

Letters1 July 1994Letters: Omeprazole and Vitamin B12Stefan P. Marcuard, MDStefan P. Marcuard, MDEast Carolina University School of Medicine; Greenville, NC 27858-4354Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-1-199407010-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Our study design to evaluate protein-bound B12 absorption before and during treatment with omeprazole is appropriate and is known as “self-pairing” [1, 2]. This method eliminates the variability between study patients and “controls.” Although we agree that a placebo group would have strengthened our results, our straightforward study design is adequate to show changes in vitamin B12 absorption during omeprazole therapy.Dr. Lavy's comments indicate a misunderstanding of vitamin B12 digestion and absorption. To correct protein-bound vitamin B12 malabsorption, hydrochloric acid (not vitamin B12) is added to the modified Schilling tests. In fact, this has been done by ...References1. Louis TA, Lavori PW, Bailar JC, Polansky M. Crossover and self-controlled designs in clinical research. In: Bailar JC, Mosteller F, eds. Medical Uses of Statistics. Waltham, Massachusetts: NEJM Books; 1986:67-90. Google Scholar2. Colton T. Paired samples. In: Colton T, ed. Statistics in Medicine. Boston: Little, Brown; 1974:131-6. Google Scholar3. Kemp JA, Golner BB, Russell RM. Effect of an acidic dietary drink on absorption of protein-bound vitamin B12 (Abstract). Gastroenterology. 1992; 102:560A. Google Scholar4. Marcuard, SP, Albernaz L, Khazanie PG. Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12). Ann Intern Med. 1994; 120:211-5. Google Scholar Author, Article, and Disclosure InformationAuthors: Stefan P. Marcuard, MDAffiliations: East Carolina University School of Medicine; Greenville, NC 27858-4354 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis 1 July 1994Volume 121, Issue 1Page: 74KeywordsAchlorhydriaCyanocobalaminDigestionHydrochloric acidProteinsVagotomy ePublished: 15 August 2000 Issue Published: 1 July 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...