tbuckley/cabot-search huggingface dataset:
Lovastatin and Hypospermia
Authors: R.D. Hildebrand, T.W. Hepperlen
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 April 1990Lovastatin and HypospermiaR.D. Hildebrand, MD, T.W. Hepperlen, MDR.D. Hildebrand, MDSearch for more papers by this author, T.W. Hepperlen, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-7-549_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: We report a potential adverse effect of lovastatin (Mevacor, Merek & Co., Inc., West Point, Pennsylvania). We treated our patient, a 38-year-old man, with lovastatin for hyperlipidemia. His past medical history was remarkable for possible sarcoid in his lungs, but this disease had never been diagnosed, and the symptoms and findings had all dissipated 3 or 4 years before our evaluation; otherwise, the patient's history was negative.The patient had a healthy child, and family history was unremarkable for hyperlipidemia. The patient tried diet modification but did not bring his cholesterol levels down from 261 mg/dL. As... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLovastatinA Reappraisal of the Risks and Benefits of Treating to Target with Cholesterol Lowering DrugsLIPID – REGULATING DRUGSStatin Adverse EffectsLovastatinEffects of simvastatin and prevastatin on gonadal function in male hypercholesterolemic patientsEffects of long-term simvastatin treatment on testicular and adrenal steroidogenesis in hypercholesterolemic patientsDrugs affecting lipid metabolismUsing lipid-lowering agents effectively 1 April 1990Volume 112, Issue 7Page: 549-550KeywordsChild healthCholesterolDietHyperlipidemiaLungs Issue Published: 1 April 1990 PDF DownloadLoading ...
Suppression of Clonal Dominance in Cultured Human Lymphoid Cells by Addition of the cHS4 Insulator to a Lentiviral Vector
Authors: Marguerite V Evans-Galea, Matthew M Wielgosz, Hideki Hanawa, Deo Kumar Srivastava, Arthur W Nienhuis
Journal: Molecular Therapy (2007)

Lentiviral vectors efficiently transduce quiescent stem cells and are being evaluated for gene therapy of blood dis-orders. The risk of genotoxicity as a result of insertional mutagenesis is an important safety consideration. The hy-persensitive site 4 insulator from the chicken beta-globin locus (cHS4) possesses chromatin bar-rier and enhancer-blocking functions. A control lentiviral vector encoding green fluorescent protein was compared with a vector in which the cHS4 insulator element flanked the green fluorescent protein expression cassette in single cell isolates of transduced human T cells (Jurkat) after 9 days in culture. The insulator had minimal effect on mean fluorescent intensity and only modestly reduced the variability of green fluorescent protein expression among indi-vidual single cell isolates. Most unique integration sites were within genes, but the insulator-containing vector had a moderate predilection to integrate near the transcriptional start site compared with the control vector. Clonal domi-nance developed in cultures of cells containing the integrated vector genomes, as reflected by the recovery of mul-tiple single cell isolates containing the same integration site. We infer that certain integrations conferred a prolifera-tive or survival advantage by affecting gene expression through insertional mutagenesis, leading to this clonal dominance. This effect was diminished by including the insulator element in the vector genome.
Fixed eruptions: causative drugs and challenge tests
Authors: K. KAUPPINEN, S. STUBB
Journal: British Journal of Dermatology (2006)

The drugs responsible for eighty-six cases of fixed drug eruption have been identified, and in all but two were confirmed by challenge. The series included sixteen cases of generalized bullous fixed eruption, which resembles Lyell's syndrome. The main causative drugs were phenazones and barbiturates, both in the series as a whole and in the group of the most severe cases. The same drugs were the most frequent causative agents in a report from Finland 10 years ago.
The Epidemiology of Tuberculosis
Authors: Lieutenant Charles W. Ochs
Journal: JAMA (1962)

Airborne transmissions of primary pulmonary tuberculosis have been well substantiated by many experimental animal and controlled pilot ward studies. However, analysis of few spontaneous human tuberculosis outbreaks have been able to substantiate this mode of transmission. In 1959 an outbreak of tuberculosis which occurred in the U.S. Navy offered an excellent opportunity for intensive and directed investigation of tuberculosis in a restricted community. Within an 18-month period, 62 of the ship's 236-man complement acquired tuberculosis. Serial tuberculin and roentgenographic studies were employed in following the course of the tuberculosis outbreak. The primary significance of airborne infection in the absence of an open case, and the efficacy of extensive decontamination were well demonstrated.
Should medical students be taught alternative medicine?
Authors: G. Catto, N. Cork, G. Williams
Journal: BMJ (2014)

<h3>Objective:</h3> To investigate the dynamics of IgG1 and IgG4 anti-citrullinated protein antibody (ACPA) subclasses during anti-tumour necrosis factor (TNF) treatment in patients with rheumatoid arthritis (RA). <h3>Methods:</h3> IgG, IgG1 and IgG4 ACPA levels were determined by ELISA on anti-citrullinated fibrinogen (ACF) and IgG1 : IgG4 ACPA ratios were calculated. A pilot study was performed in 28 ACF-positive patients treated with infliximab for one year. Confirmation of the results was obtained using a cohort of 180 consecutive patients treated with adalimumab for 28 weeks. <h3>Results:</h3> The median reduction in ACF levels was 31% for total IgG, 29% for IgG1, 40% for IgG4 and 22% for the IgG4 : IgG1 ACF ratio in the infliximab cohort. In adalimumab-treated patients, ACF levels declined 14% for total IgG and IgG1, and 36% for IgG4 ACF; the IgG4 : IgG1 ratio was reduced by 24% (all percentage values p&lt;0.05). The decrease in antibody levels was correlated with the clinical response; European League Against Rheumatism good responders had the greatest decline in antibody levels and this effect was most pronounced for IgG4 (48% reduction). The IgG4 : IgG1 ACF ratio preferentially decreased in patients with adequate therapeutic adalimumab levels. <h3>Conclusion:</h3> ACPA subclass distribution is modulated by effective anti-inflammatory treatment. The preferential decline of IgG4 ACPA, reflected by the decreased IgG4 : IgG1 ratio, suggests a beneficial effect of anti-TNF treatment on chronic antigenic stimulation by citrullinated proteins. This effect may be directly anti-TNF mediated or the result of effective dampening of the inflammation in the rheumatoid joint.
USE OF CHLORIN IN RESPIRATORY INFECTIONS IN 1833
Authors: Austin O'Malley
Journal: JAMA (1924)

To the Editor:  —In the American Journal of the Medical Sciences ( 15 : 243, 1834) is the following note:  Transactions medicales for February, 1833, contains an interesting article on this subject by Dr. Bourgeois. The physician having seen two apparently desperate phthisical patients relieved, without being submitted to any medical treatment, but who resided at a bleaching establishment near St. Denis, the atmosphere of which is impregnated with chlorin, was induced to form a similar atmosphere in the chambers of some young phthisical patients in the Royal School at St. Denis. This medication, though it did not cure these patients, ameliorated their condition, diminished their dyspnea, promoted sleep, gave them appetite, and destroyed the fetor of their sputa.
US is urged to expand its healthcare workforce to cope with surge in number of elderly people
Authors: Bob Roehr
Journal: BMJ (2008)

The ageing of the “baby boomer” generation and an increase in life expectancy will almost double the number of Americans aged 65 years or older by 2030. How to pay for the resulting increase in demand for health care is a major concern, says a new report from the US Institute of Medicine released this week at a news conference in Washington, DC.

An often unacknowledged truth, said John Rowe, who chaired the study group that produced the report, is that “even if there is enough money, there isn’t going to be anybody there to provide the care.”

Dr Rowe, a geriatrician, has had an academic career at Harvard and Columbia University medical schools and …
Ferdinando Gianotti and the Papular Acrodermatitis of Childhood: A Scientist Against All the Odds
Authors: Federico Gianotti, Filippo Pesapane, Raffaele Gianotti
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Jean Katherine Patterson (née Ritchie)
Authors: John Lennard-Jones
Journal: BMJ (2005)

​FormerFormer director research records department, St Mark's Hospital, London (b 1923; q Oxford 1946; FFR, MRCP, DM), died from lung cancer on 28 July 2005.




Figure 1




Jean's early career as a radiotherapist was followed by marriage and bringing up a family. In the mid-1960s the Ileostomy Association appointed her to assess the outcome of current surgical treatment for colitis, which established Jean as a meticulous clinical researcher and gave her an abiding interest in the treatment of inflammatory bowel disease. St Mark's responded by appointing her as research fellow and later as director of its research records department. In retirement, Jean enjoyed her interest in natural history, especially bird watching, at which she became an expert. Predeceased by her husband, Pat, she leaves two children and two grandchildren.
Adherence to IDDM Regimens: Relationship to Psychosocial Variables and Metabolic Control
Authors: Lorraine C Schafer, Russell E Glasgow, Kevin D McCaul, Mark Dreher
Journal: Diabetes Care (1983)

Thirty-four adolescents (ages 12–14 yr) with IDDM completed a questionnaire assessing regimen adherence over the previous week and psychosocial measures potentially related to adherence. Four aspects of the IDDM regimen were studied: insulin injections, dietary patterns, glucose testing, and exercise. Psychosocial variables included (1) Social Learning Theory measures of diabetes-specific family behaviors and barriers to adherence and (2) more general measures of family interaction. Glycosylated hemoglobin levels were predicted accurately (R = 0.68) from a combination of three adherence measures. The psychosocial measures were not directly related to metabolic control, but they were associated with adherence. Degree of adherence to one aspect of the IDDM regimen was not related to adherence to other aspects of the regimen and different psychosocial variables predicted adherence to different regimen components. The diabetes-specific measures were generally more predictive of adherence than were the more global measures. Implications and limitations of this cross-sectional, correlational study were discussed.
An R Factor Defects to Our Side
Authors: George A. Jacoby
Journal: New England Journal of Medicine (1972)

IN the battle between antibiotics and gram-negative bacilli much of the enemy's strategy is dictated by twisted circles of DNA known as R factors. R factors replicate autonomously within the cell as extrachromosomal genetic elements that can be transferred to other strains on contact by conjugation. First recognized as the cause of multiple drug resistance among shigella in Japan in the 1950's,1 R factors are now known to be worldwide in distribution and account for much of the antibiotic resistance among gram-negative pathogens. Indeed, there is good reason to believe that they existed well before the discovery and use of . . .
AMMONIUM CHLORIDE DECALCIFICATION, AS MODIFIED BY CALCIUM INTAKE: THE RELATION BETWEEN GENERALIZED OSTEOPOROSIS AND OSTITIS FIBROSA
Authors: Henry L. Jaffe, Aaron Bodansky, Joseph P. Chandler
Journal: The Journal of Experimental Medicine (1932)

1. In all age groups the effects of ammonium chloride administration were found to be strikingly dependent upon the calcium intake. 2. Dogs receiving an adequate calcium diet and ammonium chloride showed less decalcification than those receiving a low calcium diet with or without ammonium chloride. 3. In the younger groups the added effect of ammonium chloride to calcium-low diet brought out more striking changes than a low calcium diet alone. 4. When the decalcification was less severe-in the oldest dogs on the low calcium diet with or without ammonium chloride, and in the younger dogs on an adequate calcium intake with ammonium chloride -generalized thinning of the bones without marrow fibrosis resulted (osteoporosis). 5. When the decalcification was rapid and severe-in the youngest dogs on low calcium diet, particularly with ammonium chloride- generalized decalcification and secondary marrow fibrosis resulted (ostitis fibrosa). 6. Generalized ostitis fibrosa is a rather inclusive term and may be applied to the histologic picture which results when clinical or experimental decalcification is rapid, and therefore leads to extensive marrow fibrosis. 7. The special underlying causes of the decalcification may incidentally contribute features to modify the generalized osteoporosis or ostitis fibrosa as in rickets and in von Recklinghausen's disease.
Repeated miscarriages may be explained by deficient T cells
Authors: A. Berger
Journal: BMJ (1998)

Women who experience unexplained recurrent abortions may have a different immune profile from women who have full term pregnancies.

Sergio Romagnani and his colleagues at the University of Florence have discovered that there is a significant difference in cytokine production between women who seem to miscarry recurrently without reason and women who do not (Nature Medicine 1998;4:1020-4). If these observations are confirmed, it may be possible to find a way to intervene therapeutically in future pregnancies.

In general, when an immune response is mounted against an infectious organism or foreign tissue the response is rapid removal or rejection by T helper 1 (Th1) cells. In mouse models it has been shown that during pregnancy the immune …
Primary Disseminated Herpes Simplex of the Newborn
Authors: Clayton E. Wheeler
Journal: JAMA (1965)

Fatal pulmonary herpes simplex of the newborn was acquired during passage through the birth canal of a mother with primary herpetic vulvovaginitis. Administration of gamma globulin to the mother before delivery and to the infant after delivery failed to prevent the disease in the infant or to alter its fatal course. Vulvovaginitis in the mother did not appear to be altered. Gamma globulin given to mother and infant contained significant amounts of herpes-neutralizing antibody and low, yet easily detectable, titers were present in the infant's serum. The probability that premature and newborn infants will develop serious or fatal herpes simplex infection after exposure makes it necessary to isolate these infants from persons with known herpes simplex. In addition to large doses of gamma globulin, cesarian section should be considered in future instances of this type.
Cholesterol nucleation from its carriers in human biles
Authors: Y. Peled, Z. Halpern, R. Baruch, G. Goldman, T. Gilat
Journal: Hepatology (1988)

This study was performed to determine whether biliary cholesterol nucleates primarily from vesicles or micelles. Twenty gallbladder biles and 12 hepatic biles from patients with gallstones as well as 16 model biles were examined. The nucleation times (days) of the biles as well as their isolated vesicular and micellar fractions were determined and their lipid composition was analyzed. In 41 of 46 comparisons, cholesterol nucleated faster from vesicles than micelles; in only one case was the opposite found. The mean (± S.D.) nucleation times of vesicles and micelles in gallbladder biles were 8.9 ± 5.4 vs. 15.4 ± 8.6, in hepatic biles 14.6 ± 9.4 vs. 20.6 ± 9.1, and in model biles 9.0 ± 3.7 vs. 18.9 ± 9.1 days, respectively. All these differences were significant (p &lt; 0.005). Gallbladder biles (n = 7) devoid of vesicles nucleated more slowly (9.0 ± 9.5 days), as compared to gallbladder biles (n = 13) containing vesicles (3.8 ± 2.2 days). The nucleation time of gallbladder and hepatic biles was significantly correlated with the nucleation time of the vesicles from these biles (r = 0.847, p &lt; 0.05). There was no correlation with the nucleation time of micelles from the same biles. The percentage of cholesterol carried by vesicles in bile was positively correlated to the molar percentage of biliary cholesterol and the cholesterol saturation index and negatively correlated to the molar percentage of bile salts. Our data suggest that phospholipid vesicles are the major vehicle for cholesterol precipitation in bile as well as an important determinant of the nucleation time of bile.
Quality Improvement of Care Transitions and the Trend of Composite Hospital Care
Authors: Giffin W. Daughtridge, Traci Archibald, Patrick H. Conway
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biological influences on criminal behaviour: how good is the evidence?
Authors: J. S Alper
Journal: BMJ (1995)

example, rates of assault on public transport in three Dutch cities were reduced when 1200 unemployed young people were hired as inspectors.'7Similarly, the installation of closed circuit television on the London underground has reduced muggings and theft.Neighbourhood watch schemes have, however, resulted in few measurable falls in crime.Interestingly, it is in situational crime prevention that the adoption of violence as a public health issue is having greatest effect.In the United States case-control studies have shown an increased risk of homicide and suicide in homes where firearms are available.The availability of handguns was responsible for a sevenfold difference in the rate of homicide between Seattle, in the United States, and Vancouver, in Canada, despite a similar incidence of assault in the two cities'8-a finding that was influential in the success of the Brady bill on gun control in the United States.Public health approaches have also helped to define risk of injury due to assault in relation to alcohol consumption.In urban violence in Britain consumption of more than 10 units of alcohol in a six hour period has been linked to more severe injury, and consumption of 8 to 15 units has distinguished injured from uninjured men in the same environments.19As the consequences of violence become more apparent in terms of increased morbidity and cost the need for doctors to join forces with social scientists to tackle this problem becomes ever more obvious.Evidence also exists that, independently of socioeconomic variables, injury in violent crime is linked to adolescents with a history of drug misuse, elective surgery, and trauma.20 Preventing crime and violence should be a central issue in health care.
Vitamin A toxicity and hypercalcaemia in chronic renal failure.
Authors: W K Stewart, L W Fleming
Journal: BMJ (1981)

belt crosses the right costal margin, the sternum, and clavicle.Thus no part of the harness is able to compress the uterus.The worry that use of a seat belt may harm a fetus is largely engendered by the poor standards of design and fitting of seat belts.We should be educating pregnant women in their correct use, not encouraging the women to risk trauma due to lack of restraint.The harness used by private pilots and sporting motorists may in some cases impinge on the gravid uterus and needs to be considered individually.
Long-term vasodilator therapy for heart failure: clinical response and its relationship to hemodynamic measurements.
Authors: B Massie, T Ports, K Chatterjee, W Parmley, J Ostland, J O'Young, F Haughom
Journal: Circulation (1981)

To assess the clinical efficacy of chronic vasodilator therapy for refractory congestive heart failure, the long-term follow-up (mean 13 months, range 3-30 months) was evaluated in 56 patients treated with hydralazine, usually in combination with nitrates. In the first 6 months, 73% improved subjectively and 59% improved by one or two New York Heart Association classifications; early improvement was usually sustained. Mortality was high, 22% at 6 months and 37% at 12 months, but was significantly lower in patients who had a clinical response to vasodilators (21% in responders vs 55% in nonresponders at 1 year). The only clinical indicator that differentiated responders from nonresponders was the presence or absence of symptomatic progression before initiation of vasodilator therapy. Pulmonary artery pressure, pulmonary capillary wedge (PCW) pressure and stroke work index (SWI) before and during vasodilator therapy correlated with clinical response and survival. Fifteen of 20 patients with PCW &lt; 20 mm Hg and SWI greater than or equal to 30 g-m/m2 improved and survived, compared with two of 19 with PCS greater than or equal to 20 mm Hg and SWI &lt; 30 g-m/m2. Patients who did not have acute hemodynamic improvement generally did not improve clinically, but neither the percentage change nor the absolute change in any hemodynamic variable predicted outcome in the remaining patients. The findings of this study indicate that vasodilators produce clinical improvement in many patients with refractory heart failure and that hemodynamic measurements are helpful in predicting the outcome of therapy.