tbuckley/cabot-search huggingface dataset:
Differences in muscle blood flow in upper and lower extremities of patients after correction of coarctation of the aorta.
Authors: M Samánek, J Goetzová, J Fiserová, J Skovránek
Journal: Circulation (1976)

Using the method 133Xe clearance we investigated blood flow and calculated vascular resistances simultaneously in the muscles of the upper and lower extremities in 58 patients following successful surgical correction of aortic coarctation carried out at age 11.5 (+/- 2.9) years. The interval from operation to investigation was 11.5 (+/- 4.5) years. Resting and maximal ischemic exercise blood flows in the upper extremity were decreased and the duration of maximal blood flow was shortened. Values recorded from the lower extremities did not differ from normal controls. The difference between upper and lower extremities was statistically significant. Vascular resistance during maximal blood flow was higher in the upper extremities than in the lower. Differences between upper and lower extremities did not change after vasodilation elicited by amyl nitrite. The degree of differences was not dependent upon the age at operation, the age of the patients at investigation, or on the time interval between operation and investigation.
A European Association of Clinical Pathologists
Authors: E. J. Bigwood, J. O. Gavronsky, A. Delikatova, M. Mandelbaum, B. L. Della Vida, F. Pick, F. Duran-Jorda, G. Popjak, S. C. Dyke, F. Silberstein, S. Fransman, G. Ungar
Journal: BMJ (1943)
Arsenic Poisoning and White Lightning
Authors: Robert M. Failing
Journal: JAMA (1966)

<h3>To the Editor:—</h3> There is a rather lengthy question (<b>194</b>:1338, 1965) regarding arsenic poisoning from a physician in North Carolina. It would be well worth knowing if the alcohol ingested was "moonshine" whiskey. As North Carolina leads the nation in the number of confiscated illicit stills (and probably in the production of "tax-free" whiskey) there is, conceivably, a good possibility the alcohol consumed by the patient was of this type. Numerous impurities, including arsenic, are found in "white lightning" produced in the backwoods stills. Like many other of our present day trades, the workman has lost a certain amount of pride in this particular profession. The pure copper still has at times been replaced by certain bits of galvanized metal and other noncupric substances with high contents of impurities, including arsenic. If illicit whiskey ("white lightning" or "moonshine") was, indeed, what the patient had been consuming over a period
Jane Austen's doctors and patients
Authors: G. Dunea
Journal: BMJ (1996)

An inexorable natural selection ordains that works of art that survive 200 years are likely to have outstanding merit. So then with Jane Austen's novels, enjoying a recent upsurge in popularity, in films and on television, and also allowing us to catch a few glimpses of the medical practice of the times. Compared with modern American doctors, the surgeons and apothecaries of 1800 were poorer and less exalted in status. Thus in Sanditon Sam is “only a surgeon,” and Miss Edwards's parents are looking “much higher.” But with American medicine on a slippery slope since the 1970s, the new generation of American …
Treatment of Osgood-Schlatter Injury
Authors: Adrian L. Grass
Journal: JAMA (1978)

To the Editor.—  In QUESTIONS AND ANSWERS (239:143, 1978), Bernard R. Cahill, MD, gave his opinion that Injection of hydrocortisone into the tibial tubercle has no role in the treatment of this  [Osgood-Schlatter disease].  I would like to oppose this opinion strongly. In the first place, a patient wants treatment for a painful condition when one is available. The patient does not want to sit around doing nothing for one year, two years, or whatever length of time, if it can be avoided. He wants treatment, and taking someone out of activities is not much in the way of treatment, in my opinion.  Personally, I have injected dozens of tibial tubercles over the years with a mixture of lidocaine (Xylocaine) and triamcinolone (Aristocort), not hydrocortisone, and rarely does one have to restrict the patient's activities.  Also, in most cases the swelling goes down completely or considerably. To date, I
Points: Payment for notification of infectious diseases
Authors: J Hardiman
Journal: BMJ (1982)

A Ledermann and colleagues (12 June, p 1784) reporting thrombocytopenia following benoxaprofen therapy.They state that thrombocytopenia associated with benoxaprofen has not been reported before.We reported thrombocytopenia in association with leucopenia and toxic epidermal necrolysis in a 62- year-old woman after only nine days' treatment with benoxaprofen, and this was published in May 1982.
Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo
Authors: Hermann C Altmeppen, Johannes Prox, Berta Puig, Mark A Kluth, Christian Bernreuther, Dana Thurm, Ellen Jorissen, Bettina Petrowitz, Udo Bartsch, Bart De Strooper, Paul Saftig, Markus Glatzel
Journal: Molecular Neurodegeneration (2011)

The cellular prion protein (PrPC) fulfils several yet not completely understood physiological functions. Apart from these functions, it has the ability to misfold into a pathogenic scrapie form (PrPSc) leading to fatal transmissible spongiform encephalopathies. Proteolytic processing of PrPC generates N- and C-terminal fragments which play crucial roles both in the pathophysiology of prion diseases and in transducing physiological functions of PrPC. A-disintegrin-and-metalloproteinase 10 (ADAM10) has been proposed by cell culture experiments to be responsible for both shedding of PrPC and its α-cleavage. Here, we analyzed the role of ADAM10 in the proteolytic processing of PrPC in vivo.Using neuron-specific Adam10 knockout mice, we show that ADAM10 is the sheddase of PrPC and that its absence in vivo leads to increased amounts and accumulation of PrPC in the early secretory pathway by affecting its posttranslational processing. Elevated PrPC levels do not induce apoptotic signalling via p53. Furthermore, we show that ADAM10 is not responsible for the α-cleavage of PrPC.Our study elucidates the proteolytic processing of PrPC and proves a role of ADAM10 in shedding of PrPC in vivo. We suggest that ADAM10 is a mediator of PrPC homeostasis at the plasma membrane and, thus, might be a regulator of the multiple functions discussed for PrPC. Furthermore, identification of ADAM10 as the sheddase of PrPC opens the avenue to devising novel approaches for therapeutic interventions against prion diseases.
A CLINICAL STUDY OF HEMIPLEGIA IN THE ADULT.
Authors: THEODORE H. WEISENBURG
Journal: JAMA (1905)

There is no organic nervous disease more common than hemiplegia or a disease of which there has been more written, and yet the study of hemiplegia is always interesting and profitable. Advantage was taken of the excellent opportunities offered by the nervous wards of the Philadelphia General Hospital to make a study of hemiplegia. A number of cases were also studied in the nervous services of the University and the Polyclinic hospitals. In all 160 cases were observed. Particular attention was paid to the following subjects: Heredity, prehemiplegic and posthemiplegic pain, atrophy of the muscles of the paralyzed and of the sound side, respiration, the various trophic phenomena, as edema and the arthropathies, vasomotor disturbances and hemichorea. Of the 160 clinical cases, only 109 were considered in the study of heredity, prehemiplegic and posthemiplegic pain and sensation, because of the unreliability of some of the statements or the
Castration for Prostatic Hypertrophy
Authors: J. Swain
Journal: BMJ (1895)

THE reception by the medical profession here and elsewhere of the suggestion made by me in June, 1893, that castration might be an effectual remedy for prostatic hypertrophy has been increasingly favourable.Up to that time no reference existed in surgical literature to the possibility of affecting the overgrowth by the removal of the testes.Since then, twelve more or less successful cases have been published.It is not too much to say that, in connection with the further corroborative evidence that has been brought forward, they serve to establish the operation as a rational and justifiable procedure.I have already reviewed' the history of eight of these cases.2The other four may be briefly summarised as follows:Mayer and Haenel3 operated, May 16th, 1894, on a man about 70, with a much enlarged prostate, cystitis, and ammoniacal urine, tenesmus and toxuemia, in whom catheterism was becoming impossible on account of the pain it excited.There were several ounces of residual urine.Some improvement was noted in a few days; after two weeks the tonicity of the bladder began to return; in three weeks the urine was nearly nor- -mal; and in six weeks the prostate had shrunk to its proper dimen- -sions, the bladder emptied itself completely, no catheter being required; ,urination was performed only once in four hours, and the urine was timpid and of acid reaction.
Increased collagen turnover is only partly associated with collagen fiber deposition in the arterial response to injury
Authors: J Sluijter
Journal: Cardiovascular Research (2003)

Objective: In the arterial response to injury, collagen breakdown has been studied extensively, but little is known on collagen synthesis and fiber formation. Here, we studied in vivo collagen synthesis and collagen fiber content in relation to collagen breakdown following arterial balloon injury. Methods and results: Twenty-five New Zealand White rabbits were balloon dilated in femoral and iliac arteries and terminated at 2, 7, 14 and 28 days. From day 7, both constrictive arterial remodeling and intimal hyperplasia were observed. Collagen degradation, synthesis and fiber content were studied using zymography, quantitative Polymerase Chain Reaction, Western blotting and picrosirius red staining. Collagen synthesis, reflected by procollagen I and heat shock protein 47 (Hsp47) expression, increased at day 2 with a maximum at day 14 and was accompanied by increased collagen breakdown as reflected by matrix metalloproteinase-1 and -2 levels. Collagen content in media and adventitia only increased between days 2 and 7 after balloon injury. Conclusions: In the first week after arterial injury, increased collagen content is associated with increased collagen synthesis and degradation. However, after 1 week, collagen turnover remains high in contrast to increased collagen fiber content. This suggests that after 1 week, collagen turnover is used for other processes like cell migration and arterial remodeling.
822-6 Restenosis after sirolimus-eluting stent implantation: Long-term evaluation following repeat percutaneous intervention
Authors: Pedro A Lemos, Chourmouzios A Arampatzis, Angela Hoye, Joost Daemen, Francesco Saia, Andrew T.L Ong, Georgios Sianos, Jiro Aoki, Pieter C Smits, Willem J van der Giessen, Pim de Feyter, Eugenne McFadden, Sjoerd H Hofma, Ron T van Domburg, Patrick W Serruys
Journal: Journal of the American College of Cardiology (2004)
A breach of professional etiquette.
Authors: M R Martin
Journal: BMJ (1980)

maximum part-time contracts" he states that "'many regions regard travel, administration, and emergency duties as representing two NHDs weekly for the generality of maximum part-time consultants."This seems to indicate that in those many regions maximum part- time consultants will be contracted to work for 28 hours in order to qualify for 10/1 lths of the whole-time salary.It would be helpful if Mr Bolt could com-
de Quervain's Disease
Authors: George W. Wharton
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Tenovaginitis of the first dorsal compartment of the wrist involving the abductor pollicis longus and the extensor pollicis brevis tendons is commonly encountered by orthopedic and hand surgeons. This affliction, known as de Quervain's disease, is usually seen in adults. Females reportedly predominate by ratios of eight or ten to one. It is curious that the literature makes no reference to this disease in children. In fact, the youngest age at which this condition has previously been reported is 20 years of age.<sup>1</sup>Lapidus reported that of 432 patients with tenovaginitis only 3.5% were encountered in children up to 10 years of age, and in all these the involvement was of the flexor pollicis longus tendon.<sup>2</sup>Against this background we present here an abstract of this unusual case. <h3>Report of a Case:—</h3> A 2-year-old Negro child was referred to the hospital because of a tender
Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice
Authors: Ken-ichiro Kosai, Kunio Matsumoto, Hiroshi Funakoshi, Toshikazu Nakamura
Journal: Hepatology (1999)

Sepsis and endotoxemia are involved in the development of fulminant hepatic failure, the prognosis of which is extremely poor and the mortality is high, with no available effective therapy. Here, we report that hepatocyte growth factor (HGF) exerts potent antiapoptotic effects in vivo and effectively prevents endotoxin-induced fulminant hepatic failure in mice. The animals were intraperitoneally injected three times with 120 μg human recombinant HGF or saline 6 hours and 30 minutes before and 3 hours after an intraperitoneal injection of lipopolysaccharide (LPS) and d -galactosamine (GalN). Administration of LPS + GalN, without HGF, rapidly led to massive hepatocyte apoptosis and severe liver injury, and all mice died of hepatic failure within 8 hours. In contrast, administration of human recombinant HGF strongly suppressed extensive progress of hepatocyte apoptosis and the liver injury induced by LPS + GalN, and 75% of the HGF-treated mice survived. Moreover, HGF strongly induced Bcl-xL expression and blocked apoptotic signal transduction upstream of CPP32 (caspase-3) in the liver, thereby leading to inhibition of massive hepatocyte apoptosis. We suggest that HGF may well have the potential to prevent fulminant hepatic failure, at least through its potent antiapoptotic action.
Radionuclide Assessment in Nocturnal Asthma
Authors: N D GREYSON, R H REID, Y C LIU, P THOMAS
Journal: Clinical Nuclear Medicine (1982)

GREYSON, N D M.D., F.R.C.P.(C); REID, R H M.B., Ch.B.; LIU, Y C M.D., F.R.C.P.(C); THOMAS, P M.B., M.R.C.P.(U.K.), F.R.C.P.(C), F.C.C.P. Author Information
RECENT ADVANCES IN THE PHYSIOLOGY OF HUMAN NUTRITION.
Authors: FRANK BILLINGS
Journal: JAMA (1905)

The question of the physiology of nutrition is a most important one. It is especially important to the physician, for without a clear idea of the subject he can not prescribe a proper dietary for the well or sick nor can he clearly understand the pathologic conditions which occur as a result of an improper amount or kind of food or the morbid conditions which result from malnutrition. It is the belief of the layman and of many physicians, too, that the chief nutrition of food consists of the proteids, and meat is especially looked on as the food which affords strength and sustained effort. Among Europeans and Americans especially meat eating is very prevalent, chiefly for the reasons given above. Besides this, the palate is pleasantly excited by rich animal foods, and in consequence a larger amount is taken. It is too common a belief that the well-nourished body
Pathological completion: The blind leading the mind?
Authors: Robin Walker, Jason B. Mattingley
Journal: Behavioral and Brain Sciences (1998)

The taxonomy proposed by Pessoa et al. should be extended to include “pathological” completion phenomena in patients with unilateral brain damage. Patients with visual field defects (hemianopias) may “complete” whole figures, while patients with parietal lobe damage may “complete” partial figures. We argue that the former may be consistent with the brain “filling-in” information, and the latter may be consistent with the brain ignoring the absence of information.
Glutamate-Induced AMPA Receptor Desensitization Increases Their Mobility and Modulates Short-Term Plasticity through Unbinding from Stargazin
Authors: Audrey Constals, Andrew C. Penn, Benjamin Compans, Estelle Toulmé, Amandine Phillipat, Sébastien Marais, Natacha Retailleau, Anne-Sophie Hafner, Françoise Coussen, Eric Hosy, Daniel Choquet
Journal: Neuron (2015)

Short-term plasticity of AMPAR currents during high-frequency stimulation depends not only on presynaptic transmitter release and postsynaptic AMPAR recovery from desensitization, but also on fast AMPAR diffusion. How AMPAR diffusion within the synapse regulates synaptic transmission on the millisecond scale remains mysterious. Using single-molecule tracking, we found that, upon glutamate binding, synaptic AMPAR diffuse faster. Using AMPAR stabilized in different conformational states by point mutations and pharmacology, we show that desensitized receptors bind less stargazin and are less stabilized at the synapse than receptors in opened or closed-resting states. AMPAR mobility-mediated regulation of short-term plasticity is abrogated when the glutamate-dependent loss in AMPAR-stargazin interaction is prevented. We propose that transition from the activated to the desensitized state leads to partial loss in AMPAR-stargazin interaction that increases AMPAR mobility and allows faster recovery from desensitization-mediated synaptic depression, without affecting the overall nano-organization of AMPAR in synapses.Video AbstracteyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiJjNzc3YzgxNzY4NzA0NTI2ZDc1ZjgzOGE0MjRmZTI0MCIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjc4NzQ2OTU5fQ.CtzeB74eER9_-oMOyHt_X2B7gd1qwVFx6fJm-srYEO_HWVbnMLr9DC-wKFrR7-6Zkq9R67VyYKHWZao7-FWVZ6kvElOf6cnRyPjL7haU23z0pPpNVO2HGvwmCBdCoxGA_FBXarbaiMM0RvygP4DlxeQVNYDKnEdOfe6i4_pamKZStoVaK5OrlTI-mftHc5vcANUxi-oPqTPgUxPleBCypYN4b2tXyVxL8wFvDewqanV0EBzDI5h75H4eBAYHIMIIpm8nmr4X0DIPjE7p8O3-gFStHyG1bRkSstho9VjLoJ3dANA2GeEb3oU8seEiOokhCr44HYb1BGZuQBSNp9zHSg(mp4, (86.07 MB) Download video
Local Monitoring of Antibiotic Resistance
Authors: JOHN P. SHEEHAN
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 May 1984Local Monitoring of Antibiotic ResistanceJOHN P. SHEEHAN, M.D.JOHN P. SHEEHAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-5-771_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent editorial by Kunin (1) has highlighted the global problem of antibiotic resistance and the need for ongoing surveillance by individual physicians and hospital teams. In general, physicians acting alone are responsible for initiating antibiotic therapy, frequently on an urgent, blind, empiric basis, based on prevailing antibiotic-resistance patterns and pending definitive culture and sensitivity results. In this setting, the need to audit one's practice, to define both unnecessary or inappropriate antibiotic therapy and local changes in antibiotic resistance patterns, is of great importance.The value of such local surveillance was most apparent to me during a...References1. KUNIN C. Antibiotic resistance—a world health problem we cannot ignore [Editorial]. Ann Intern Med. 1983;99:859-60. LinkGoogle Scholar2. HODGECIAKTRAMONT WJE. Simple method for detection of penicillinase producing Neisseria gonorrhoeae. J Clin Microbiol. 1978;7:102-3. CrossrefMedlineGoogle Scholar3. PHILPOTT-HOWARDWILLIAMS JJ. Increase in antibiotic resistance in Haemophilus influenzae in the United Kingdom since 1977. Br Med J. 1982;284:1597-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1984Volume 100, Issue 5Page: 771-771KeywordsAntibiotic resistanceAntibiotics ePublished: 1 December 2008 Issue Published: 1 May 1984 PDF downloadLoading ...
A targeted, multifactorial intervention reduced mortality in patients with type 2 diabetes and microalbuminuria
Authors: Om P. Ganda
Journal: Annals of Internal Medicine (2008)

ACP Journal Club19 August 2008A targeted, multifactorial intervention reduced mortality in patients with type 2 diabetes and microalbuminuriaOm P. Ganda, MDOm P. Ganda, MDJoslin Diabetes Center, Boston, Massachusetts, USA (O.P.G.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-4-200808190-02004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationGaede P, Lund-Andersen H, Parving HH, Pedersen O. Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med. 2008;358:580-91. https://pubmed.ncbi.nlm.nih.gov/18256393Clinical Impact RatingsGIM/FP/GP: Cardiology: Endocrinology: References1 Gaede P, Vedel P, Larsen N, et al. Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med. 2003;348:383-93. [PMID: 12556541] Google Scholar2 Kearney PM, Blackwell L, Collins R, et al. Efficacy of cholesterol-lowering therapy in 18, 686 people with diabetes in 14 randomised trials of statins: a meta-analysis. Lancet. 2008;371:117-25. [PMID: 18191683] Google Scholar3 Stratton IM, Cull CA, Adler AI, et al. Additive effects of glycaemia and blood pressure exposure on risk of complications in type 2 diabetes: a prospective observational study (UKPDS 75). Diabetologia. 2006;49:1761-9. [PMID: 16736131] Google Scholar4 Nathan DM, Cleary PA, Backlund JY, et al. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med. 2005;353:2643-53. [PMID: 16371630] Google Scholar Author, Article, and Disclosure InformationAuthors: Om P. Ganda, MDAffiliations: Joslin Diabetes Center, Boston, Massachusetts, USA (O.P.G.)This article was published at Annals.org on 5 August 2008. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 August 2008Volume 149, Issue 4Page: JC2-4KeywordsMicroalbuminuriaMortalityMyocardial infarctionNeuropathyNumber needed to treatPercutaneous coronary interventionRenal diseasesRetinopathyRevascularizationType 2 diabetes ePublished: 19 August 2008 Issue Published: 19 August 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Please don't make a fuss, dear
Authors: M. J Chamberlain
Journal: BMJ (1997)

My mother reached 86 with her hearing, vision, and all her wits intact, living alone, and enjoying life. Then a neighbour found her semiconscious, bleeding from a head wound. She had struck her head on the sideboard and crawled to the telephone. The left hemiparesis was quickly evident and became dense.

She was admitted to the local general hospital where she had previously had a cardiac pacemaker inserted and been treated for mild hypertension and presumed angina. Unfortunately, no trace of the previous hospital records could be found. The paralysed limbs became oedematous, deep vein thrombosis was considered and rejected, a diuretic was prescribed.

Mother complained of dry mouth and urinary urgency. An antimicrobial was prescribed, although examination of the mouth did not reveal any thrush. Three weeks after admission my sister asked the consultant physician whether subdural haematoma had been considered. She was told that it had and had been excluded by computed tomography, but no scan had been performed.

By now Mother was being nursed in a stroke rehabilitation unit where the television was on at full volume distracting patients and visitors alike. It was kind of an aid to bring a cup of tea but not to leave it on a table on her left side to which she showed the anticipated inattention complete with the spilt food down her left side. The inattention to the left side led to a recurrent problem with her …