tbuckley/cabot-search huggingface dataset:
Differences among young adults, adults and elderly chronic myeloid leukemia patients
Authors: F. Castagnetti, G. Gugliotta, M. Baccarani, M. Breccia, G. Specchia, L. Levato, E. Abruzzese, G. Rossi, A. Iurlo, B. Martino, P. Pregno, F. Stagno, A. Cuneo, M. Bonifacio, M. Gobbi, D. Russo, A. Gozzini, M. Tiribelli, A. de Vivo, G. Alimena, M. Cavo, G. Martinelli, F. Pane, G. Saglio, G. Rosti, F. Salvi, M. Pini, P. Leoni, S. Rupoli, P. Galieni, C. Bigazzi, N. Cantore, F. Palmieri, F. Albano, A. Russo Rossi, A. Rambaldi, T. Intermesoli, F. Palandri, N. Testoni, S. Luatti, S. Soverini, I. Iacobucci, M.T. Bochicchio, M. Apolinari, M. Fogli, I. Cervello, A. Capucci, M. Malagola, A. Malpignano, M. Girasoli, E. Angelucci, E. Usala, S. Storti, E. De Biasi, G. Tagariello, R. Sartori, F. Di Raimondo, P. Vigneri, S. Impera, S. Molica, F. Lanza, C. Viganò, M. Grasso, D. Rapezzi, F. Cavazzini, A. Bosi, V. Santini, S.F. Capalbo, G. Spinosa, I. Pierri, M. Bergamaschi, A.M. Carella, A. Bacigalupo, A. De Blasio, F. Ciccone, N. Di Renzo, C. Musolino, S. Russo, A. Cortelezzi, E. Morra, E.M. Pungolino, M. Luppi, R. Marasca, E.M. Pogliani, C. Gambacorti-Passerini, L. Luciano, F. Ferrara, M. Annunziata, G. Latte, D. Noli, G. Rege-Cambrin, C. Fava, G. Semenzato, G. Binotto, F. Fabbiano, D. Turri, S. Siragusa, C. Caracciolo, M. Musso, F. Porretto, F. Aversa, M. Crugnola, M. Cazzola, E. Orlandi, B. Falini, F. Falzetti, G. Visani, A. Isidori, G. Fioritoni, R. Di Lorenzo, D. Vallisa, E. Trabacchi, M. Petrini, S. Galimberti, M. Pizzuti, A. Zaccaria, M. Salvucci, F. Ronco, D. Ielo, F. Merli, P. Avanzini, P. Tosi, A. Merli, P. Musto, V. De Stefano, S. Sica, R. Latagliata, P. De Fabritiis, M. Trawiska, I. Majolino, L. Pacilli, B. Ronci, M. Cedrone, M.C. Petti, F. Pisani, A. Tafuri, E. Montefusco, F. Iuliano, F. Dore, S. Pardini, M. Bocchia, M. Defina, A.M. Liberati, D. Luzzi, M. Boccadoro, D. Ferrero, U. Vitolo, F. Gherlinzoni, E. Calistri, R. Fanin, G. Pizzolo, V. Meneghini, F. Rodighiero, A. D'Emilio
Journal: Annals of Oncology (2014)
Evaluation for Coronary Artery Disease and Medicare Spending—Reply
Authors: Jacqueline Baras Shreibati
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Four-cluster analysis: a simple method to test phylogenetic hypotheses.
Authors: A. Rzhetsky, S. Kumar, M. Nei
Journal: Molecular Biology and Evolution (1995)

A simple statistical test for comparing three alternative phylogenetic hypotheses for four monophyletic groups is presented. This test is based on the minimum-evolution principle, and it does not require any information regarding the branching order within each monophyletic group. It is computationally efficient and can be easily extended to five or more monophyletic groups.
Thalamic amnesia and the hippocampus: Unresolved questions and an alternative candidate
Authors: Robert G. Mair, Joshua A. Burk, M. Christine Porter, Jessica E. Ley
Journal: Behavioral and Brain Sciences (1999)

Aggleton &amp; Brown have built a convincing case that hippocampus-related circuits may be involved in thalamic amnesia. It remains to be established, however, that their model represents a distinct neurological system, that the distinction between recall and familiarity captures the roles of these pathways in episodic memory, or that there are no other systems that contribute to the signs of amnesia associated with thalamic disease.
750 PRECLINICAL PHARMACOKINETIC PROFILE OF IDX320, A NOVEL AND POTENT HCV PROTEASE INHIBITOR
Authors: S.S. Good, X.-R. Pan-Zhou, M. Larsson, S. Luo, J.R. Selden, H. Rashidzadeh, S. Bhadresa, M. Camire, C. Parsy, D. Surleraux
Journal: Journal of Hepatology (2010)
CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells
Authors: Hiroaki Niiro, Siamak Jabbarzadeh-Tabrizi, Yoshikane Kikushige, Takahiro Shima, Kumiko Noda, Shun-ichiro Ota, Hirofumi Tsuzuki, Yasushi Inoue, Yojiro Arinobu, Hiromi Iwasaki, Shinji Shimoda, Eishi Baba, Hiroshi Tsukamoto, Takahiko Horiuchi, Tadayoshi Taniyama, Koichi Akashi
Journal: Blood (2012)
Depressant effect of acetate in isolated cardiac tissue
Authors: J T DAUGIRDAS, X WANG, C NUTTING, V SWANSON, A AGRAWAL
Journal: Cardiovascular Research (1988)

Because acetate may have cardiodepressant properties in vitro, but previous studies have not separated out effects of acetate from possible effects of osmolality, sodium concentration, or calcium complexing, the effects of isosmotic acetate substitution (at a constant calcium concentration) on contractility were studied in isolated rat atrial tissue and in an isolated perfused non-working whole heart preparation. In spontaneously contracting right atrial tissue acetate induced dose dependent inhibition of isometric tension in the clinically important dose range of 4 to 16 mmol·litre−1. Bath acetate concentrations of 4, 16, or 64 mmol·litre−1 reduced peak tension (mean(SEM)) to 78(2.7)%, 56(2.5)%, or 61(4.6)% respectively of control values. Because the calcium concentrations of the acetate baths were set equal to that of the control bath, calcium complexing by acetate could not have accounted for acetate's cardiodepressant effect. The inhibitory action was demonstrable with both isosmotic and hyperosmotic acetate solutions. Acetate had no effect on the spontaneous rate of atrial contraction. Inhibition of contractility (+dP/dt) by acetate in the whole heart preparation was also demonstrable at bath acetate concentrations of 8 and 16 mmol·litre−1. The results suggest that acetate has a myocardial depressant effect in vitro at concentrations achievable in the plasma during haemodialysis. The myocardial depressant action is not dependent on calcium complexing or on changes in bath osmolality or sodium concentration.
Development of a Multiplex Quantitative PCR Signature to Predict Progression in Non–Muscle-Invasive Bladder Cancer
Authors: Rou Wang, David S. Morris, Scott A. Tomlins, Robert J. Lonigro, Alexander Tsodikov, Rohit Mehra, Thomas J. Giordano, L. Priya Kunju, Cheryl T. Lee, Alon Z. Weizer, Arul M. Chinnaiyan
Journal: Cancer Research (2009)

Abstract In bladder cancer, clinical grade and stage fail to capture outcome. We developed a clinically applicable quantitative PCR (QPCR) gene signature to predict progression in non–muscle-invasive bladder cancer. Comparative metaprofiling of 12 DNA microarray data sets (comprising 631 samples and 241,298 probe sets) identified 96 genes, which showed differential expression in seven clinical outcome categories, or were identified as outliers, historic markers, or housekeeping genes. QPCR was done to determine mRNA expression from 96 bladder tumors. Fifty-seven genes differentiated T2 from non-T2 tumors (P &amp;lt; 0.05). Principal components analysis and Cox regression models were used to predict probability of T2 progression for non-T2 patients, placing them into high- and low-risk groups based on their gene expression. At 2 years, high-risk patients exhibited greater T2 progression (45% for high-risk patients versus 12% for low-risk patients; P = 0.003, log-rank test). This difference remained significant within T1 tumors (61% for high-risk patients versus 22% for low-risk patients; P = 0.02) and Ta tumors (29% for high-risk patients versus 0% for low-risk patients; P = 0.03). The best multivariate Cox model included stage and gender, and this signature provided predictive improvement over both (P = 0.002, likelihood ratio test). Immunohistochemistry was done for two genes in the signature not previously described in bladder cancer, ACTN1 and CDC25B, corroborating their up-regulation at the protein level with disease progression. Thus, we identified a 57-gene QPCR panel to help predict progression of non–muscle-invasive bladder cancers and delineate a systematic, generalizable approach to converting microarray data into a multiplex assay for cancer progression. [Cancer Res 2009;69(9):3810–8]
Endoscopic review of patients who have had gastric surgery.
Authors: P A Farrands, J R Blake, I D Ansell, R E Cotton, J D Hardcastle
Journal: BMJ (1983)

Seventy one patients who had had operations on their stomachs over 15 years previously were examined by endoscopy and multiple mucosal biopsy sampling. Sixty six had histologically proved gastritis (56 chronic atrophic gastritis, 10 superficial gastritis), 38 intestinal metaplasia, and 11 epithelial dysplasia. In three cases the epithelial dysplasia was severe (carcinoma in situ). One patient had an infiltrating carcinoma and another, whose biopsy appearances were reported as severe dysplasia, developed a carcinoma of the stomach eight months later. All patients having undergone gastric surgery more than five years previously should be screened endoscopically and any found to have moderate dysplasia subjected to regular endoscopic screening thereafter. Patients with severe dysplasia (carcinoma in situ) should be considered for radical surgery.
Abstract 3499: Funding innovative technologies for cancer research at the National Cancer Institute
Authors: Anthony Dickherber
Journal: Cancer Research (2014)

Abstract In the fall of 2013, the National Cancer Institute re-launched the Innovative Molecular Analysis Technologies (IMAT) program, committing up to $10.5 million through unique funding mechanisms (3 year R21s and R33s) to better support investigators through both the early and advanced stages of technology development over traditional funding mechanisms for exploratory research. The IMAT program has supported the development of various analytical and sample processing platforms that have made substantial contributions across the cancer research continuum, and the process of winning an award remains highly competitive. A variety of IMAT-supported research projects will be highlighted to demonstrate the variety and high level of innovation evident in the IMAT portfolio of supported research. An emphasis will be placed on recently completed projects so that investigators interested in next generation tools may become aware of possible developments through NCI-funded projects for their research. In addition, trends from recently awarded projects will be described to provide insight for potential applicants on the nature of the program and the competition. Potential projects of interest and identified technology gaps will also be discussed. The IMAT program continues to represent a unique resource for highly innovative technology development. Citation Format: Anthony Dickherber. Funding innovative technologies for cancer research at the National Cancer Institute. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3499. doi:10.1158/1538-7445.AM2014-3499
Hepatitis C, cryoglobulinemia, and cirrhosis: A meta-analysis
Authors: Zeid Kayali, Victor E. Buckwold, Bridget Zimmerman, Warren N. Schmidt
Journal: Hepatology (2002)

Approximately 40% of patients with chronic hepatitis C virus (HCV) infection develop detectable serum cryoglobulins or cryoprecipitates (CP), although most do not show clinical or physical signs of syndromic cryoglobulinemia. Although association of HCV with the extrahepatic complications of cryoglobulinemia is widely recognized, the relationship of cryoglobulinemia with liver disease is unclear. We wished to study the relationship between CP and cirrhosis and to determine whether the development of CP is a true covariate for progressive liver disease or a confounding variable that impacts cirrhosis because of patient age, duration of disease, or differences in gender. We undertook a meta-analysis of 19 studies published between 1994 and 2001. The incidence of cirrhosis was compared in patients with and without CP after logistic regression adjustments for accepted risk factors for progressive liver disease, including age, gender, and estimated duration of disease (EDD). A total of 2,323 patients with chronic hepatitis C were identified, with 1,022 (44%) having detectable CP. Cirrhosis was present in 40% of patients with CP but only 17% of patients without CP (total χ 2 = 141.69, P &lt; .001). After adjusting for age, gender, and estimated duration of disease by logistic regression, the combined odds ratio for incidence of cirrhosis in patients CP positive versus CP negative was 4.87, (95% CI: 3.32, 7.15), indicating a highly significant association between cirrhosis and cryoglobulinemia. In conclusion, cryoglobulins may be a useful prognostic indicator for increased risk of cirrhosis with chronic hepatitis C.
Cervical Cytology and Reimbursement Issues
Authors: Yener Erozan, Shirley Greening, Prabodh Gupta, Beverly Kraemer, Robert Kurman, Ronald Luff, Dorothy Rosenthal, Patricia Saigo, Diane Solomon, George Wied
Journal: JAMA (1990)

To the Editor.—  Two commentaries accompanied the publication of the 1988 Bethesda System. 1 Dr Malkasian, 2 representing the American College of Obstetricians and Gynecologists, repeated his organization's support for the use of uniform, descriptive terminology for cervical/vaginal cytological diagnoses as developed in The Bethesda System, but questioned the concept of the cytopathologic interpretation as a medical consultation. He maintained that it may be inappropriate for cytopathologists to provide direction to physicians for further patient evaluation and/or treatment.  Dr Ohrt, 3 representing Blue Cross and Blue Shield, also embraced The Bethesda System as an improved approach to reporting cervical/vaginal cytological diagnoses, but questioned the reasons for the workshop's affirmation of the cytopathology report as a medical consultation. He speculated that this might have been done to increase reimbursement levels for cytopathology services without clearly adding value.  We wish to elaborate on the rationale and intent of the workshop's determination that
A woman with a sore spot on her leg
Authors: Jenny Caesar, Periasamy Balasubramaniam
Journal: BMJ (2014)

A 41 year old civil servant, with a background of poorly controlled Crohn’s disease, presented to her general practitioner with a skin lesion on her left shin that had been there for eight weeks (fig 1⇓).



The lesion had started as a small red blemish, “like a burn,” that appeared acutely and rapidly grew in size. She could not recall any injuries to this area. It was painful to touch and she had noticed some purplish discoloration around the edges of the wound. Although it started to heal in some areas it was also enlarging at the periphery.

She was worried about “passing it on” to her children and had covered it with a bandage.

She had no known allergies and was taking sulfasalazine for her inflammatory bowel disease.



### 1. How would you describe the skin lesion?

#### Short answer

Irregular plaque with cribriform (uneven) scarring and purplish discoloration, multiple tiny ulcerations, and pustules at the edge.

#### Long answer

The lesion consisted of an inflammatory plaque measuring 7 cm in diameter, with cribriform (uneven) scarring and tiny ulcerations with pustules at the periphery (fig 2⇓). Although multiple clinical variants are noted (see long answer 2) the classic description of this lesion would be a painful ulcerative lesion, with a purulent base and well defined violaceous border.1 The border of the ulcer is often described as overhanging or undermined. This feature is caused by the spread of inflammation throughout the …
NAIL-FOLD CAPILLARY LOOP DEVELOPMENT IN THE INFANT OF LOW BIRTH WEIGHT
Authors: J. SYME, I. D. RILEY
Journal: British Journal of Dermatology (1970)

Observations were made of the capillary loops in the nail-folds of 87 infants in the neonatal period. The time of appearance of such loops is not determined by age, dating from birth, but by weight and hence maturity.
An unusual cause of patchy ground-glass opacity
Authors: N Just, J Delourme, C Delattre, A Liesse, F Steenhouwer
Journal: Thorax (2008)

In November 2006 a 33-year-old man was admitted with acute respiratory distress following a suicide attempt (50 hydroxyzine tablets and a vial of diazepam). The patient’s medical history included a heroin and cocaine addiction which was substituted …
Influence of HLA polymorphism on persistent remission in rheumatoid arthritis
Authors: E T H Molenaar
Journal: Annals of the Rheumatic Diseases (2002)

Several studies have reported an association between the presence of the shared epitope (SE) and susceptibility to rheumatoid arthritis (RA). Recent studies have shown that certain HLA-DRB1 alleles in combination with predisposing DQB1 and DQA1 alleles may protect against the development of RA. This model is known as the rheumatoid arthritis protection (RAP) hypothesis.To determine the distribution of HLA-DRB1 and DQB1/DQA1 alleles in a cohort of patients with RA in remission and to determine the association between these HLA alleles and the persistence of remission.HLA-DRB1 and DQB1 typings were performed in 167 patients with RA in remission, defined according to the American College of Rheumatology criteria. The disease course, as defined by the persistence of remission during a follow up of two years, was compared between subgroups. According to the RAP hypothesis patients were divided into three subgroups: patients carrying predisposing DQ alleles, patients carrying predisposing alleles in combination with protective alleles (DQ(RA+)/DERAA phenotype), and patients lacking the predisposing alleles. According to the SE hypothesis, patients were divided into three subgroups based on whether they were carrying two, one, or no predisposing alleles (SE alleles).Predisposing DQ alleles along with a DERAA-bearing allele were present in 14 (8%) of the 167 patients. At least one SE allele was present in 116 (69%) patients; 34 of them (20%) were carrying two copies. The disease course was not significantly different between the subgroups according to the SE and RAP hypothesis, respectively.The frequency of DQ(RA+)/DERAA combinations and of SE alleles in patients with RA clinically in remission was similar to that found in other RA populations. Persistent remission of RA was not associated with any particular HLA subtypes, indicating that HLA typing is not useful for predicting persistent clinical remission.
Coming to Life: Reflections on the Art of Psychotherapy
Authors: Alan Stoudemire
Journal: JAMA (1994)

While the term<i>psychotherapy</i>suggests a healing process directed toward the emotional life, there are perhaps well over 100 various types of psychotherapy that have been described and advocated by their respective proponents. If one were to attempt to reduce the various types to major categories, the five leading schools would be psychoanalytic, cognitive-behavioral, interpersonal, family systems, and, more recently, "self psychology." The last was elaborated and systematically developed by the late Heinz Kohut and was based on his theories of normal and pathological narcissism. Although this book is not directed toward formal techniques or concepts— and the writer never formally states what philosophy his therapeutic approach is based upon—it is self psychology that the book most likely reflects. This type of psychotherapy is based on ascertaining how damage and distortion in this "narcissistic" line of development has affected the patient's self-concept and subsequent interpersonal relationships. The author presents 11
Diagnostic Miscues in Congenital Long-QT Syndrome
Authors: Nathaniel W. Taggart, Carla M. Haglund;, David J. Tester, Michael J. Ackerman
Journal: Circulation (2007)

Long-QT syndrome (LQTS) is a potentially lethal cardiac channelopathy that can be mistaken for palpitations, neurocardiogenic syncope, and epilepsy. Because of increased physician and public awareness of warning signs suggestive of LQTS, there is the potential for LQTS to be overdiagnosed. We sought to determine the agreement between the dismissal diagnosis from an LQTS subspecialty clinic and the original referral diagnosis.Data from the medical record were compared with data from the outside evaluation for 176 consecutive patients (121 females, median age 16 years, average referral corrected QT interval [QTc] of 481 ms) referred with a diagnosis of LQTS. After evaluation at Mayo Clinic's LQTS Clinic, patients were categorized as having definite LQTS (D-LQTS), possible LQTS (P-LQTS), or no LQTS (No-LQTS). Seventy-three patients (41%) were categorized as No-LQTS, 56 (32%) as P-LQTS, and only 47 (27%) as D-LQTS. The yield of genetic testing among D-LQTS patients was 78% compared with 34% for P-LQTS and 0% among No-LQTS patients (P<0.0001). The average QTc was greater in either D-LQTS or P-LQTS than in No-LQTS (461 versus 424 ms, P<0.0001). Vasovagal syncope was more common among the No-LQTS subset (28%) than the P-LQTS/D-LQTS group (8%; P=0.04). Determinants for discordance (ie, positive outside diagnosis versus No-LQTS) included overestimation of QTc, diagnosing LQTS on the basis of "borderline" QTc values, and interpretation of a vasovagal fainting episode as an LQTS-precipitated cardiac event.Diagnostic concordance was present for less than one third of the patients who sought a second opinion. Two of every 5 patients referred with the diagnosis of LQTS departed without such a diagnosis. Miscalculation of the QTc, misinterpretation of the normal distribution of QTc values, and misinterpretation of symptoms appear to be responsible for most of the diagnostic miscues.
Nazi s euthanasia files are made public
Authors: A. Tuffs
Journal: BMJ (2003)

For the first time, files relating to the 200 000 euthanasia crimes of the Nazi regime from 1939 to 1944 are available online in a central databank.

The German Federal Archive in Berlin has gathered information from almost 300 archives in Germany, Austria, Poland, and the former Czechoslovakia.

The research project was partly financed by the German Medical Association. Speaking at the press launch in Berlin, the association's honorary president, Karsten Vilmar, once …
The Distribution of Ulcerative Colitis and Regional Enteritis in United States Veterans with Particular Reference to the Jewish Religion
Authors: E. D. Acheson
Journal: Gut (1960)

In a sample of patients, discharged from Veterans Administration Hospitals in the United States, suffering from ulcerative colitis and regional enteritis and mixed forms of these diseases, the proportion of Jews was four times as high as in a corresponding sample of general medical and surgical patients.