Heated Clotting Factors and Seroconversion for Human Immunodeficiency Virus in Three Hemophilic Patients
Authors: G. Mariani, A. Ghirardini, F. Mandelli, P. Verani, S. Buttó, G.B. Rossi, P. M. Mannucci
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 July 1987Heated Clotting Factors and Seroconversion for Human Immunodeficiency Virus in Three Hemophilic PatientsG. MARIANI, M.D., A. GHIRARDINI, M.D., F. MANDELLI, M.D., P. VERANI, M.D., S. BUTTÓ, Ph.D., G.B. ROSSI, M.D., P. M. MANNUCCI, M.D.G. MARIANI, M.D.Search for more papers by this author, A. GHIRARDINI, M.D.Search for more papers by this author, F. MANDELLI, M.D.Search for more papers by this author, P. VERANI, M.D.Search for more papers by this author, S. BUTTÓ, Ph.D.Search for more papers by this author, G.B. ROSSI, M.D.Search for more papers by this author, P. M. MANNUCCI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-1-113 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Clotting factor concentrates have been heated since 1984 to inactivate human immunodeficiency virus (HIV). Hemophilic patients seronegative for HIV treated exclusively with heated concentrates at first showed no seroconversion (1-3). Later, two hemophiliacs seroconverted after having been treated with the same factor VIII concentrate that had been heated in the lyophilized state (freeze-dried) at 60 °C for 30 hours (4, 5). This relatively low heating temperature and short time period might be insufficient to inactivate HIV. During our follow-up of 63 hemophiliacs who were seronegative before the exclusive usage of heated concentrates was initiated, three became persistently...References1. ROUZIOUX C, CHAMARET S, MONTAGNIER L, CARNELLI V, ROLLAND G, and MANNUCCI P. Absence of antibodies to AIDS virus in hemophiliacs treated with heat-treated factor VIII concentrate [Letter]. Lancet. 1985; 1:271-2. CrossrefMedlineGoogle Scholar2. MÖSSELER J, SCHIMPF K, AUERSWALD G, BAYER H, SCHNEIDER J, and HUNSMANN G. Inability of pasteurized factor VIII preparations to induce antibodies to HTLV-III after long-term treatment [Letter]. Lancet. 1985;1:1111. CrossrefMedlineGoogle Scholar3. FELDING P, NILSSON I, and HANSSON B. Absence of antibodies to LAV/HTLV-III in hemophiliacs treated with heat-treated factor VIII concentrate of American origin [Letter]. Lancet. 1985;2:832-3. CrossrefMedlineGoogle Scholar4. WHITE G, MATTHEWS T, and WEINHOLD K. HTLV-III seroconversion associated with heat-treated factor VIII concentrate [Letter]. Lancet. 1986;1:611-2. CrossrefMedlineGoogle Scholar5. VAN DEN BERG W, TEN CATE J, BREEDERVELD G, and GOUDSMIT J. Seroconversion to HTLV-III in hemophiliac given heat-treated factor VIII concentrate [Letter]. Lancet. 1986;1:803-4. CrossrefMedlineGoogle Scholar6. Survey of non-US hemophilia treatment centers for HIV seroconversion following therapy with heat-treated factor concentrates. MMWR. 1987;36:121-3. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: G. MARIANI, M.D.; A. GHIRARDINI, M.D.; F. MANDELLI, M.D.; P. VERANI, M.D.; S. BUTTÓ, Ph.D.; G.B. ROSSI, M.D.; P. M. MANNUCCI, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInfectious Agents Transmitted by TransfusionPathogen Inactivation: The Definitive Safeguard for the Blood SupplyPathogen inactivation technology: cleansing the blood supply5 The choice of plasma-derived clotting factor concentratesViral safety of plasma-derived and recombinant products used in the management of haemophilia A and BPrevalence of Infection with the Hepatitis C Virus among Italian Hemophiliacs before and after the Introduction of Virally Inactivated Clotting Factor Concentrates: A Retrospective EvaluationClinical Evaluation of Viral Safety of Coagulation Factor VIII and IX ConcentratesLow risk of transmission of the human immunodeficiency virus by a solvent-detergent-treated commercial factor VIII concentrateEpidemiology of human immunodeficiency virus infection and acquired immunodeficiency syndromeNational survey of human immunodeficiency virus infection in Italian hemophiliacs: 1983–1987 1 July 1987Volume 107, Issue 1Page: 113-113KeywordsHIVTemperature ePublished: 1 December 2008 Issue Published: 1 July 1987 PDF downloadLoading ...