Warfarin-Carbamazepine Interaction
Authors: ALAN G. KENDALL
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 February 1981Warfarin-Carbamazepine InteractionALAN G. KENDALL, M.D., MARIE BOIVINALAN G. KENDALL, M.D., MARIE BOIVINAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-2-280_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In 1971 Hansen and associates (1) reported a reduction in serum warfarin half-life in two patients due to the concomitant administration of carbamazepine (Tegretol; Ciba-Geigy Corporation, Summit, New Jersey). The postulated mechanism was that of hepatic microsomal enzyme induction (2). Although this report was alluded to briefly in a recent article in the Annals on the use of antiepileptic drugs (3), no reference to this interaction was made in a recent article in the Medical Letter on Drugs and Therapeutics (4). Furthermore, appropriate warning is not given in the manufacturer's product monograph.We have recently observed a...References1. HANSENSIERSBOCK-NIELSONSKOVSTED IKL. Carbamazepine-induced acceleration of diphenylhydantoin and warfarin metabolism in man. Clin Pharmacol Ther. 1971;12:539-43. CrossrefMedlineGoogle Scholar2. RICHENSWOODFORD AF, eds. Anticonvulsant Drugs and Enzyme Induction. Amsterdam: Associated Scientific Publishers; 1976. Google Scholar3. PENRYNEWMARK JM. The use of antiepileptic drugs. Ann Intern Med. 1979;90:207-18. LinkGoogle Scholar4. Adverse interactions of drugs. Med Lett Drugs Ther. 1979;21:5-12. MedlineGoogle Scholar5. CALLAGHANO'CALLAGHANDUGGANFEELY NMBM. Carbamazepine as a single drug in the treatment of epilepsy. J Neurol Neurosurg Psychiatry. 1978;41:907-12. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Royal Victoria Hospital Montreal, Quebec Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByWarfarin Interaction With Hepatic Cytochrome P-450 Enzyme-Inducing AnticonvulsantsThe effect of carbamazepine on warfarin anticoagulation: a register-based nationwide cohort study involving the Swedish populationClinically Significant Interactions with Mood StabilisersCardiovascular DrugsCase report: dose adjustment of warfarin using genetic information and plasma concentration monitoringThe impact of interacting drugs on dispensed doses of warfarin in the Swedish population: A novel use of population based drug registersCardiovascular DrugsDrug-Drug Interactions Between Warfarin and Psychotropics: Updated Review of the LiteratureDrug-Drug Interactions Between Warfarin and Psychotropics: Updated Review of the LiteratureEffect of eslicarbazepine acetate on the steady-state pharmacokinetics and pharmacodynamics of warfarin in healthy subjects during a three-stage, open-label, multiple-dose, single-period studyCardiovascular MedicationsRisk and Predictability of Drug Interactions in the ElderlyThe influence of co-treatment with carbamazepine, amiodarone and statins on warfarin metabolism and maintenance doseINTERACTIONS OF WARFARINInhibition of phenprocoumon anticoagulation by carbamazepineWarfarin-Felbamate Interaction: First ReportEffect of carbamazepine on coumadin metabolismDrugs affecting blood clotting, fibrinolysis and hemostasis 1 February 1981Volume 94, Issue 2Page: 280-280KeywordsAntiepileptic drugDrug interactionsDrug therapyDrugsEnzymesHalf life Issue Published: 1 February 1981 PDF DownloadLoading ...