tbuckley/cabot-search huggingface dataset:
Trends in incidence of primary brain tumors in the United States, 1985-1994
Authors: Patti J. Jukich, Bridget J. McCarthy, Tanya S. Surawicz, Sally Freels, Faith G. Davis
Journal: Neuro-Oncology (2001)

Brain tumor incidence has increased over the last 20 years in all age groups, both overall and for specific histologies. Reasons attributed to these increases include increase in lymphoma due to HIV/AIDS, introduction of computed tomography/magnetic resonance imaging, and changes in coding/classification. The purpose of this study was to describe overall and histologic-specific incidence trends in a population-based series of primary benign and malignant brain tumors. Data from the Central Brain Tumor Registry of the United States from 1985 through 1994 were used to determine incidence trends in the broad age groups 0-19, 20-64, and 65 years, both overall and for selected histologies. Poisson regression was used to express trends as average annual percentage change. Overall, incidence increased modestly (annual percentage change 0.9%, 95% confidence interval, 0.4, 1.4). When lymphomas were excluded, this result was not statistically significant (annual percentage change 0.5%, 95% confidence interval, 0.1, 1.1). Specific histologies that were increasing were lymphomas in individuals aged 20 to 64 years and in males aged 65 years or older, ependymomas in the population aged 20 to 64 years, nerve sheath tumors in males, and pituitary tumors in females. Increases that were not specific to any population subgroup were seen for glioblastoma, oligodendrogliomas, and astrocytomas, excluding not otherwise specified (NOS) tumors. Corresponding decreases were noted for NOS, astrocytoma NOS, and glioma NOS. Increasing incidence trends for lymphomas were consistent with previous literature. Improvements in diagnostic technology in addition to changes in classification and coding were likely to be responsible for decreases seen in incidence of NOS subgroups and corresponding increases in glioma subgroups. In contrast, the increases identified for ependymomas, nerve sheath tumors, and pituitary tumors were less likely to be artifacts of improvements in diagnosis, and they warrant further study.
Access to Employee Exposure and Medical Records
Authors: James H. Sammons
Journal: JAMA (1978)

THE PROPOSED rule "Access to Employee Exposure and Medical Records" (<i>Federal Register</i>43:31371 [July 21] 1978) would require any employer who makes, maintains, or has access to employee exposure records or employee medical records to preserve and retain such records for the duration of that person's employment and for five years following the termination of employment. These records would have to be made available for copying and inspection to employees, former employees, or a designated representative thereof. These records would also have to be made available to the Occupational Safety and Health Administration (OSHA) and the National Institute of Occupational Safety and Health (NIOSH). This proposed rule would apply to all exposure or medical records whether or not maintained pursuant to a specific occupational safety and health standard. The confidentiality of patientphysician communications is an essential element in the provision of good medical care. It helps to ensure free and
Thunderstorm associated asthma: a detailed analysis of environmental factors
Authors: A. Celenza, J. Fothergill, E. Kupek, R. J Shaw
Journal: BMJ (1996)

To seek associations between meteorological factors, concentrations of air pollutants or pollen, and an asthma epidemic which occurred in London on 24 and 25 June 1994 after a thunderstorm.Retrospective study of patients' accident and emergency department records, with bivariate and multivariate analysis of environmental factors and data collection for the two months surrounding the epidemic.The accident and emergency department of St Mary's Hospital in west central London.148 patients presenting with asthma between 1 June and 31 July 1994, of whom 40 presented in the 24 hours after the storm.The asthma epidemic was significantly associated with a drop in air temperature six hours previously and a high grass pollen concentration nine hours previously. Non-epidemic asthma was significantly associated with lightning strikes, increase in humidity or sulphur dioxide concentration, a drop in temperature or high rainfall the previous day, and a decrease in maximum air pressure or changes in grass pollen counts over the previous two days.New episodes of asthma during the epidemic on 24 and 25 June 1994 were associated with a fall in air temperature and a rise in grass pollen concentration. Non-epidemic asthma was significantly associated with a greater number of environmental changes. This may indicate that the patients with thunderstorm associated asthma were a separate population, sensitive to different environmental stimuli.
New Pathways for Medical Education
Authors: Daniel C. Tosteson
Journal: JAMA (1991)

It is timely and encouraging to note the appearance, in this issue ofThe Journal, of an article on reform of medical education.1The editors deserve credit for featuring an article on medical education, and the authors merit praise for designing and carrying out  careful assessment of the opinions of teachers and administrators about reform.  Dr Cantor and his coauthors conclude that there is a restlessness among leaders of medical  consulted in their survey. They note that except for basic sciences faculty,  majority of educators stated that 'fundamental changes' are needed in medical student education in the United States. What are the origins of these feelings of concern in the minds of those who are responsible for educating the physicians for the future?  The authors cite several criticisms that have been made of contemporary medical education. In my opinion, the prevalent anxiety of medical educators is
Transcription and enhancer profiling in human monocyte subsets
Authors: Christian Schmidl, Kathrin Renner, Katrin Peter, Ruediger Eder, Timo Lassmann, Piotr J. Balwierz, Masayoshi Itoh, Sayaka Nagao-Sato, Hideya Kawaji, Piero Carninci, Harukazu Suzuki, Yoshihide Hayashizaki, Reinhard Andreesen, David A. Hume, Petra Hoffmann, Alistair R. R. Forrest, Marina P. Kreutz, Matthias Edinger, Michael Rehli
Journal: Blood (2014)
Primary Sjogren's syndrome associated agranulocytosis: a benign disorder?
Authors: P. Coppo, J. Sibilia, F Maloisel, M-H Schlageter, A-L Voyer, V Gouilleux-Gruart, J Goetz, B. Desablens, B Tribout, K Lassoued
Journal: Annals of the Rheumatic Diseases (2003)

To report on an uncommon association of agranulocytosis in primary Sjögren's syndrome (SS).The clinical, haematological, and immunological features of seven patients with primary SS associated with a chronic (>6 months) agranulocytosis, and the outcome of the patients, were analysed.Patients were white women with an unexplained agranulocytosis. They all had non-erosive arthritis and three had a thrombocytopenia or Evan's syndrome. In three patients, transient or durable expansion of T lymphocytes was present in the peripheral blood or in the bone marrow, but evolved independently from neutrophil counts. There was no paroxysmal nocturnal haemoglobinuria clone or antibodies to neutrophil surface antigens. In vitro bone marrow culture was normal (four patients) or showed a decrease in colony forming unit-granulocyte monocyte (CFU-GM) and colony forming unit-erythroblast (CFU-E) (one patient). Serum levels of soluble Fas ligand (sFasL) were normal, and granulocyte-colony stimulating factor (G-CSF) concentrations were either normal or raised. One patient was treated with steroids associated with intravenous immunoglobulins and achieved a lasting response. Two other patients were treated with steroids and methotrexate, with poor efficacy. Short courses of subcutaneous G-CSF produced a transient and mild response in all three patients. Complete recovery of the neutrophils occurred temporarily during pregnancy in two patients. After a mean follow up of 34.8 months (range 6-139) all patients were alive and none developed serious infections.A subset of patients with primary SS and non-destructive arthritis may develop a chronic but well tolerated agranulocytosis that is usually poorly responsive to steroids and oral methotrexate.
Alpha-1 antitrypsin deficiency is not a rare disease but a disease that is rarely diagnosed.
Authors: Frederick J de Serres
Journal: Environmental Health Perspectives (2003)

Articles in the literature on alpha-1 antitrypsin (AAT) deficiency have been interpreted as indicating that AAT deficiency is a rare disease that affects mainly Caucasians (whites) from northern Europe. In a recent publication on the worldwide racial and ethnic distribution of AAT deficiency, new data were presented demonstrating that it is also found in various populations of African blacks; Arabs and Jews in the Middle East; and Central, Far East, and Southeast Asians, as well as whites in Australia, Europe, New Zealand, and North America. The new data on the prevalence of AAT deficiency in other major racial groups worldwide will affect the standards for the diagnosis of AAT deficiency by the medical community, with the realization that is not a rare disease of whites in northern Europe and immigrants from these countries in the New World. In a total population of 4.4 billion in the 58 countries surveyed, there are at least 116 million carriers (those with Pi phenotypes PiMS and PiMZ) and 3.4 million with deficiency allele combinations (phenotypes PiSS, PiSZ, and PiZZ) for the two most prevalent deficiency alleles PiS and PiZ; therefore, the new data suggest that AAT deficiency may be one of the most common serious single-locus genetic diseases in the world. Particularly important is the unique susceptibility of AAT-deficient individuals to exposure to chemical and particulate environmental agents. Such exposures are known to result in both lung and liver disease as well as other adverse health effects.
Principles of pediatric surgery, 2nd edition
Authors: S Reid
Journal: British Journal of Sports Medicine (2006)

Edited by James O’Neill, Jr. Published by Mosby, 2003, £102.60, pp 895, hardcover. ISBN 0323018270

Paediatric surgery matured as a discipline distinct from adult surgery during the second half of the 20th century. The first edition of this book was published in 1995 under the title Essentials of Pediatric Surgery . The second edition has been expanded to include sections on perioperative considerations such as paediatric anaesthesia, haematology, fluid and nutritional support, and respiratory and cardiac physiology. It is for this reason that the title was changed.

The stated aims of the book’s authors are for it to act as: (a) a reference text for paediatric surgeons, surgical residents of all specialties, and other surgeons who perform procedures on paediatric patients, and (b) a concise …
Terminality and Interminable Psychoanalysis: An Incomplete Report
Authors: Avery Weisman
Journal: Psychotherapy and Psychosomatics (1986)

Other Types| February 17 2010 Terminality and Interminable Psychoanalysis: An Incomplete Report Subject Area: Psychiatry and Psychology Avery Weisman Avery Weisman Boston Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1986) 45 (1): 23–32. https://doi.org/10.1159/000287923 Article history Published Online: February 17 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Avery Weisman; Terminality and Interminable Psychoanalysis: An Incomplete Report. Psychother Psychosom 1 January 1986; 45 (1): 23–32. https://doi.org/10.1159/000287923 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1986Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Abstract 9760: Population-Level Cardiovascular Health Behavior and Health Factor Trends (1988-2008) and Projections to 2020 in US Men and Women: Results from the National Health and Nutrition Examination Surveys (NHANES)
Authors: Mark D Huffman, Donald M Lloyd-Jones, Hongyan Ning, Earl S Ford, Simon Capewell
Journal: Circulation (2011)

Introduction: The AHA 2020 Impact Goals recently defined 4 health behaviors (smoking, body mass index [BMI], diet, and physical activity) and 3 health factors (cholesterol, blood pressure, and plasma glucose) that serve as population-level metrics for evaluating cardiovascular (CV) health. However, there have been no forward projections of population trends of these metrics to 2020. Methods: We used data from cardiovascular disease-free individuals from NHANES III (1988-1994) and recent 2-year cycles (1999-2000, 2001-2, 2003-4, 2005-6, 2007-8) to provide population-level, sex-specific trends in prevalence of poor, intermediate and ideal levels of CV health behavior/factors. We also performed age-adjusted forward projections to 2020 using weighted linear regression coefficients. Results: The Table describes prevalence of poor, intermediate and ideal CV health behavior/factor levels from 1988-2008, weighted linear regression coefficients β (SE), and 2020 projections for men. Favorable trends from 1988-2008 included declines in prevalence of current and former smoking, hypercholesterolemia, and hypertension. In contrast, there were adverse trends in BMI, and dysglycemia. Prevalence of physical activity levels and remarkably low diet quality scores showed minimal changes over time. Women had generally similar trends in CV health profiles. Projections to 2020 suggest that obesity and impaired fasting glucose/diabetes could increase to affect more than 45% and 75% of US men, respectively, and 42% and 55% of US women. Conclusions: Improvements in prevalence of smoking, hypercholesterolemia and hypertension since 1988 have been offset by increases in adiposity and dysglycemia in US men and women. If current trends in obesity and dysglycemia are not reversed rapidly (likely through improvements in diet and physical activity), achievement of the 2020 Strategic Impact Goals will be difficult.
Maximal values of sniff nasal inspiratory pressure in healthy subjects.
Authors: C Uldry, J W Fitting
Journal: Thorax (1995)

Inspiratory muscle strength is often better reflected by oesophageal pressure during a maximal sniff (sniff POES) than by maximal inspiratory pressure (PImax). Sniff POES can be estimated non-invasively by measuring the sniff nasal inspiratory pressure (SNIP). The aim was to establish maximal normal values for the SNIP and to compare them with PImax.One hundred and sixty healthy subjects (80 men) aged 20-80 years were recruited. All subjects had a forced vital capacity (FVC) of > 80%, a forced expiratory volume in one second (FEV1)/FVC of > 85% predicted value, and a body mass index of 18-31 kg/m2. Because PImax is known to be reduced in the supine posture, the SNIP was measured in both the sitting and the supine positions. PImax sustained over one second was measured from functional residual capacity (FRC) in the sitting position with a standard flanged mouthpiece during four manoeuvres. SNIP was measured from FRC in the sitting and supine positions using a catheter through a plug occluding one nostril during 10 maximal sniffs through the contralateral nostril. For each test the largest pressure measured in cm H2O was taken into account.For both men and women maximal SNIP was negatively correlated with age, and was similar in the sitting and the supine positions. In the sitting position maximal SNIP was greater or equal to PImax in 107 of 160 subjects. The mean (SD) ratio SNIP/PImax was 1.08 (0.22) in men and 1.17 (0.29) in women.Normal values of maximal SNIP can be predicted from age and sex. Maximal SNIP is similar in the sitting and the supine position and is significantly higher than PImax in healthy subjects. The low level of agreement between maximal SNIP and PImax indicates that the two manoeuvres are not interchangeable but complementary.
Flexible training is possible as a senior house officer
Authors: N. Redfern, P. Scriven
Journal: BMJ (1998)

BMJ 7128 Volume 316: Saturday 31 January 1998Career focus Flexible training is possible as a senior house officer

Nancy Redfern and Patricia Scriven, who are both associate postgraduate deans, explain how SHOs can take advantage of flexible training 

Flexible training is available for all doctors in training grades who have, well founded individual reasons, which prevent them working full time. This option is becoming increasingly popular

Most postgraduate deans have an associate dean to manage the flexible training scheme in their area, and with these appointments more energy has gone into publicity and recruitment. A national scheme exists for specialist registrars, described in the Guide to Specialist Registrar Training. No national scheme exists for senior house officers (SHOs), and posts are made available by the local postgraduate dean. Numbers vary according to region (fig 2).

Obtaining a flexible SHO post involves several steps. The candidate must be eligible to work flexibly and be of the same calibre as full time trainees; funding must be available; and the post must have royal college educational approval.

Information Information about flexible training is available from the local postgraduate dean's office where an associate dean may be responsible for flexible training in the region. The BMJ contains information about flexible training in this section. Undergraduate courses at British medical schools include advice on careers and full time and flexible postgraduate training. Many royal colleges have an adviser with responsibility for flexible trainees. At a more local level, college or district tutors, clinical and postgraduate tutors, and educational supervisors may be aware of flexible training, and its existence may be mentioned on induction courses. Despite all this information, some doctors in training grades are not aware that flexible training exists. Awareness that flexible training is possible seems to be lowest among overseas doctors and in …
Re: Urs E. Studer, Laurence Collette, Peter Whelan, et al. Using PSA to Guide Timing of Androgen Deprivation in Patients with T0–4 N0–2 M0 Prostate Cancer not Suitable for Local Curative Treatment (EORTC 30891). Eur Urol 2008;53:941–9 and re: John Anderson. Androgen-Deprivation Therapy—It's All a Matter of Timing. Eur Urol 2008;53:869–71
Authors: Magdi Mounir Kirollos
Journal: European Urology (2008)
Treatment by Electrically Induced Convulsions
Authors: Wm. H. Shepley, J. S. McGregor
Journal: BMJ (1939)

ConclusionI should like to take this opportunity of stressing the safety of a haemorrhoid operation when done under modern conditions and the certainty of cure of a dis- tressing and disabling complaint.The common notion among the public that haemorrhoidectomy is a very painful operation is one that should be strenuously opposed.The modern operation under local anaesthesia, with a carefully considered and well-tried after-treatment, is far from being a serious ordeal: the patient is able to walk to a bath on the third post-operative day, and the anal wounds are usually almost healed in two weeks -after operation.Summary Essential points in the preliminary examination of a case of haemorrhoids are detailed: how to recognize the difference between internal and external haemorrhoids, the three degrees of internal haemorrhoids, and other asso- ciated anal conditions.The treatment of external piles is described.The three main lines of treatment for internal piles in routine use at St. Mark's.aregiven: palliative, injection, and operative.The safety of a haemorrhoid operation done under modern conditions, and the certainty of cure, are stressed.
Study of High Frequency Components in Electrocardiogram by Power Spectrum Analysis
Authors: Ernst K. Franke, John R. Braunstein, David C. Zellner
Journal: Circulation Research (1962)

A method has been developed for recording the power spectrum of the heart's electromotive force for the time interval corresponding to the QRS complex of the conventional electrocardiogram. Standards for healthy, young normals have been established. No significant change was noted in a group of healthy, middle-aged normals without heart disease. Three different patterns, however, were found for patients with ischemic heart disease, with and without evidence of infarction.
Introduction to Reference Sources in the Health Sciences
Authors: Ann C. Weller
Journal: JAMA (1995)

Ten years ago, when the second edition of this volume was published, AIDS was just surfacing as a major health problem, the Internet was unheard of, no one knew what a virtual library was, and the Cold War seemed destined to remain a disruptive international force. Remarkably stable, however, have been the contents of this important volume. The third edition of<i>Introduction to Reference Sources in the Health Sciences</i>has added to the second edition when needed, while retaining the important elements that have made this volume such a unique information source. This handy guide's primary purpose is "to discuss various types of reference and information sources and their use in reference work in the health sciences, regardless of format," with an emphasis on US publications and libraries. As expected, the major change between the second and third editions is the inclusion of information on electronic sources. The topics cover