tbuckley/cabot-search huggingface dataset:
Improved Left Ventricular Aneurysm Repair With Bioengineered Vascular Smooth Muscle Grafts
Authors: Keiji Matsubayashi, Paul W.M. Fedak, Donald A.G. Mickle, Richard D. Weisel, Tsukasa Ozawa, Ren-Ke Li
Journal: Circulation (2003)

Background— Recurrent ventricular dilatation can occur after surgical repair of a left ventricular (LV) aneurysm. Use of an autologous bioengineered muscle graft to replace resected scar tissue may prevent recurrent dilatation and improve cardiac function. Methods— Vascular smooth muscle cells (SMCs, 5×10 6 cells) from rat aortas were seeded onto synthetic PCLA (sponge polymer of ε-caprolactone-co-L-lactide reinforced with knitted poly-L-lactide fabric) patches and cultured for 2 weeks to allow tissue formation. Syngenic rats underwent proximal left coronary artery ligation to create a transmural myocardial scar. Four weeks after coronary ligation, cell-seeded patches (n=15) or unseeded patches (n=12) were used for a modified endoventricular circular patch plasty (EVCPP) repair of the infarct area. Ligated controls (n=14) and nonligated normal rats (n=10) had sham surgeries without EVCPP. Cardiac function was assessed by echocardiography and isolated Langendorff heart perfusion. Graft histology and morphology was also assessed. Results— After 8 weeks in vivo, seeded patches were thicker ( P &lt;0.05) and smaller in area ( P &lt;0.003) than unseeded patches. Only seeded patches had prominent elastic tissue formation ( P &lt;0.001) in association with SMCs. LV systolic function by echocardiography was improved in the seeded group compared with both unseeded ( P &lt;0.002) and control groups ( P &lt;0.0001). LV volumes in both patch repair groups were comparable but were significantly smaller ( P &lt;0.05) than controls. LV distensibility tended toward improvement in the seeded group as compared with unseeded hearts, but the difference did not achieve statistical significance ( P =0.06). Conclusions— Surgical repair with muscle-cell seeded grafts reduced abnormal chamber distensibility and improved LV function after myocardial infarction as compared with unseeded grafts. Bioengineered muscle grafts may be superior to synthetic materials for the surgical repair of LV scar.
Lung, Gastric, and Soft Tissue Uptake of Tc-99m MDP and Ga-67 Citrate Associated with Hypercalcemia
Authors: CATHERINE CASTAIGNE, PHILIPPE MARTIN, DIDIER BLOCKLET
Journal: Clinical Nuclear Medicine (2003)

Metastatic calcifications are associated with chronic renal failure, hyperparathyroidism, metastatic neoplasms, hypervitaminosis D, and hypercalcemia of other origins. Bone scanning agents accumulate within these extraskeletal metastatic calcifications. The authors describe two patients with hypercalcemia associated with Tc-99m MDP uptake in the lungs, stomach, and soft tissues. Ga-67 scintigraphy was also performed and showed increased uptake in the same locations as those of Tc-99m MDP, suggesting the existence of an inflammatory process. Despite adequate treatment, only partial resolution of extraskeletal uptake was observed.
Measure of Blood Loss in Operating Room
Authors: John A. Williams
Journal: JAMA (1961)

<h3>To the Editor:—</h3> In the Jan. 7, 1961, issue ofThe Journal, page 73, there appeared an inquiry regarding methods for determining blood loss in the operating room. The published reply to this inquiry recommended weighing blood-soaked sponges, and subtracting the previous dry weight of the same materials. There are a number of defects that seriously limit the usefulness of this method. One can weigh sponges and measure what is in suction bottles, but one cannot weigh blood-soaked drapes or other linens during the operation. To obtain the dry weight of the bloody linens would require selecting the same items out of a clean kit and weighing them. This approach is cumbersome and too inaccurate to be useful in guiding replacement therapy. The information really needed is the patient's blood volume preoperatively, during the operation, and afterward, to guide accurate replacement of loss. This is now possible with a new
Angiopoietin-1 promotes endothelial differentiation from embryonic stem cells and induced pluripotent stem cells
Authors: Hyung Joon Joo, Honsoul Kim, Sang-Wook Park, Hyun-Jai Cho, Hyo-Soo Kim, Do-Sun Lim, Hyung-Min Chung, Injune Kim, Yong-Mahn Han, Gou Young Koh
Journal: Blood (2011)
Clinical diabetes mellitus.
Authors: Samuel B. Beaser
Journal: JAMA (1963)

<i>Clinical Diabetes Mellitus</i>, edited by Drs. Max Ellenberg and Harold Rifkin, is a series of review articles on diabetes mellitus which was recently published in weekly sequence in the<i>New York State Journal of Medicine</i>. There are 43 authors and 34 chapters. The topics are arranged so as to cover the entire field systematically with some inevitable variation in length. The chapters are written in the manner of review articles with a fairly complete and up-to-date bibliography comprising one-fifth of the text. It is well written, and in the "preclinical" section an attempt was made to relate the material to clinical application. It is gratifying to note chapters on dental and employment aspects of diabetes. The mature readers will find this authoritative review of diabetes a rewarding experience. In more than one sense it is neither elementary nor a textbook. Detailed discussion of diet prescription is absent and the chapter
Vasodilators in senile dementia.
Authors: A J Martin
Journal: BMJ (1979)

general condition improved rapidly from that time.However, the oedema continued to extend across his chest wall and his left arm and, more worry- ingly, up into his neck; and at one point we began to consider the possibility that tracheostomy would be required.Happily this did not prove necessary, but it was not until 4 August that the oedema began to recede, and on 13 August when the boy was discharged from hospital supervision there was still some residual swelling of his right arm.
The natural history and treatment outcome of blast phase BCR-ABL− myeloproliferative neoplasms
Authors: Constantine S. Tam, Roberto M. Nussenzveig, Uday Popat, Carlos E. Bueso-Ramos, Deborah A. Thomas, Jorge A. Cortes, Richard E. Champlin, Stefan E. Ciurea, Taghi Manshouri, Sherry M. Pierce, Hagop M. Kantarjian, Srdan Verstovsek
Journal: Blood (2008)
CONVALESCENT SERUM IN POLIOMYELITIS
Authors: E. C. Fleischner
Journal: JAMA (1926)

<h3>To the Editor:</h3> —With due consideration to Dr. Ayer's experience, it hardly seems justifiable for any man to generalize as he has done in either a positive or a negative way concerning a disease the characteristic features of which are as variable as those of poliomyelitis. It would be possible, if one were willing to take the time, to quote many references to show that Dr. Ayer's generalizations are based on a large experience, but that it is not possible to draw accurate deductions in connection with this disease from the observations of any one person or even from many case histories. In case 1, Dr. Ayer absolutely ignores the headache, the rigidity of the neck, the bilateral Kernig sign, the marked tremor and the rapid pulse, the first three of which symptoms he himself classifies as constituting "an important and almost constant triad of findings." In case 2 he
Differential expression of VH gene families in peripheral B cell repertoires of newborn or adult immunoglobulin H chain congenic mice.
Authors: A C Viale, A Coutinho, A A Freitas
Journal: The Journal of Experimental Medicine (1992)

The pattern of VH gene family expression in the primary B cell repertoire of the mouse is strain dependent. In C57Bl/6 mice, the VH J558 family is expressed by more than 45% of the cells, while the expression of VH 7183, VH Q52, and VH 36-60 families together does not exceed 20%. In BALB/c mice, relative expression of VH J558 is lower than 35%, while the sum of the other three families reaches 25%. To assess which genetic loci control strain-specific VH gene family expression, we studied VH gene family usage in splenic B cell repertoires of different congenic strains of mice. Changes in major histocompatibility complex or immunoglobulin (Ig) K light chain genes did not modify VH gene family expression in adult mice. Differences at the IgH locus, however, modified VH gene family usage. In 1-d-old mice, the strain-specific VH gene family expression pattern is determined by the IgH haplotype. In adult mice, the VH gene family expression pattern of resting B cells is independent of the IgH locus and follows the genetic background of the congenic strain, while it is determined by the IgH haplotype among Ig-secreting spleen cells. In F1(B6 x BALB/c) mice, each of the two spleen B cell populations, sorted on the basis of mu heavy chain allotype expression, shows an independent VH gene family expression pattern, determined by the IgH locus. The implications of these results in the control of VH gene family expression, and in the selection of peripheral B cell repertoires are discussed.
Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein
Authors: Trang T. Vu, Ji Zhou, Beverly A. Leslie, Alan R. Stafford, James C. Fredenburgh, Ran Ni, Shengjun Qiao, Nima Vaezzadeh, Willi Jahnen-Dechent, Brett P. Monia, Peter L. Gross, Jeffrey I. Weitz
Journal: Blood (2015)
Stimulation of granulocytopoiesis by a diffusible factor in vivo
Authors: G. Rothstein, E. H. Hügl, C. R. Bishop, J. W. Athens, H. E. Ashenbrucker
Journal: Journal of Clinical Investigation (1971)

A millipore diffusion chamber system was used to cultivate mouse marrow in the abdomens of irradiated and unirradiated host mice for 24 hr. When the irradiated hosts were 72, 96, or 120 hr postirradiation, the number of blasts and promyelocytes in the implanted chambers after cultivation was greater than those in the same marrow cultivated in unirradiated hosts. These data indicate that in vivo, there is stimulation of granulocytopoiesis by a diffusible factor or factors.
Bolus Endovascular PDGFR-β Antisense Treatment Suppressed Intimal Hyperplasia in a Rat Carotid Injury Model
Authors: Nicolas Noiseux, Caroline H. Boucher, Raymond Cartier, Martin G. Sirois
Journal: Circulation (2000)

Background —Intimal thickening in accelerated arteriopathies relies on the migration of medial vascular smooth muscle cells (VSMCs) and their proliferation within the neointima. Activation of platelet-derived growth factor receptor-β (PDGFR-β) expressed in injured VSMCs is responsible for the migration of medial VSMCs to the intima. In the present study, we wanted to assess whether a single local endovascular delivery of antisense PDGFR-β in injured rat carotid arteries would be sufficient to prevent intimal hyperplasia and how it might contribute to the vascular healing process. Methods and Results —A bolus of antisense PDGFR-β delivered into injured rat carotid arteries reduced PDGFR-β protein overexpression by &gt;90% from day 3 to 28 after injury. At day 28 after injury, compared with injured untreated carotids, treatment with antisense PDGFR-β reduced intimal hyperplasia by 58% and medial VSMC migration by 49% and improved vascular reendothelialization by 100% and vascular reactivity (EC 50 ) to acetylcholine by 5-fold. Conclusions —A single-bolus luminal delivery of antisense PDGFR-β to injured rat carotids reduced intimal hyperplasia, improved the reendothelialization process, and led to the recovery of endothelium-dependent regulation of vascular tone.
Abstract 5448: PTK7 as a potential therapeutic target in ovarian cancer
Authors: Zhihu Ding, Amanda Lennon, Keli Perron, David Harper, Hui Su, Meredith Wolfram, Joshua Murtie, Stuart Licht, Jason Pinckney, Helene Simonds-Mannes, Kimberly Bishop, Julie-Ann Gavigan, Dinesh Bangari, Maureen Magnay, William Weber, David Reczek, William Brondyk, Vicky Drewett, Marc Trombe, Dietmar Hoffmann, Raffaele Baffa, Serena Silver, Victoria Richon, Christopher Winter, Venkat Reddy, Richard C. Gregory
Journal: Cancer Research (2014)

Abstract The identification of proteins that selectively discriminate between tumor cells and normal adult cells allows for the specific targeting of diseased cells with antibody therapeutics. One such recently identified protein, PTK7, is an onco-fetal membrane protein which exhibits limited expression and function in adults. PTK7 was identified as a member of the RTK super family but lacks a functional kinase domain. Normally, PTK7 is expressed early in development and its loss is associated with severe defects in neural tube closure and sensory hair cell bundle formation. Functionally, little is known about the signaling involving PTK7, but it has been linked to both the canonical and noncanonical WNT pathways. Recently, PTK7 expression has been shown to be upregulated in a number of cancers including: ovarian, melanoma, leukemia, lung, pancreatic, colon, renal and breast. In vitro and in vivo studies support a role in regulating angiogenesis, invasion &amp; survival. To further validate PTK7 as a potential cancer target that may be required for tumor maintenance and progression, we analyzed the expression of PTK7 in normal and tumor samples, and validated an in vitro and in vivo role of PTK7 on cell growth in ovarian cancer cell lines using both genetic tools and polyclonal antibodies. Silencing PTK7 with stably expressed inducible shRNAs is shown to inhibit the growth of ovarian cancer cell lines in vitro and to lead to delayed tumor growth upon PTK7 knockdown in murine tumor xenograft models. Further supporting the role of PTK7 as a potential antibody target, polyclonal antibodies to PTK7 are shown to inhibit the growth of SKOV3 and OVCAR8 cells in vitro. Although 4 human antibodies derived from phage display failed to inhibit in vitro cell growth, these results suggest that functionally blocking PTK7 may lead to the inhibition of ovarian tumor growth and is a potential target for antibody therapies. Citation Format: Zhihu Ding, Amanda Lennon, Keli Perron, David Harper, Hui Su, Meredith Wolfram, Joshua Murtie, Stuart Licht, Jason Pinckney, Helene Simonds-Mannes, Kimberly Bishop, Julie-Ann Gavigan, Dinesh Bangari, Maureen Magnay, William Weber, David Reczek, William Brondyk, Vicky Drewett, Marc Trombe, Dietmar Hoffmann, Raffaele Baffa, Serena Silver, Victoria Richon, Christopher Winter, Venkat Reddy, Richard C. Gregory. PTK7 as a potential therapeutic target in ovarian cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5448. doi:10.1158/1538-7445.AM2014-5448
Abstract 4774: The antitumor effects of PI3K beta inhibitors in PTEN negative prostate cancer are enhanced by inhibition of reactivated PI3K alpha signaling
Authors: Sarit Schwartz, Brett S. Carver, John Wongvipat, Vanessa Rodrik-Outmezguine, Elisa D. Stanchina, Cath Trigwell, Simon Barry, Jose Baselga, Sarat Chandarlapaty, Howard I. Scher, Charles L. Sawyers, Neal Rosen
Journal: Cancer Research (2014)

Abstract The PI3K pathway is dysregulated in many cancers via selective activation of class 1 isoforms. In tumors with deficient PTEN function, signaling is driven by PI3K beta. We show here that a selective inhibitor of PI3K beta inhibits the AKT/mTOR pathway in tumors with defective PTEN function, but is ineffective in those where the pathway is driven by receptor tyrosine kinases. However, inhibition of PI3K signaling by PI3K beta inhibitors is limited by relief of AKT/mTOR dependent feedback and reactivation of IGF1R and other receptors. This results in activation of PI3K alpha and a rebound of PI3K-AKT signaling. This rebound is suppressed and tumor cell inhibition is enhanced with combined inhibition of PI3K alpha and beta. Combined administration of isoform selective PI3K inhibitors may more effectively inhibit the pathway than pan-PI3K inhibitors because of the greater selectivity and decreased off-target toxicity of the former. In PTEN deficient models of prostate cancer, triple therapy with PI3K alpha and beta selective inhibitors combined with a potent androgen receptor inhibitor suppresses the reciprocal feedback activation of both pathways and results in marked (complete) eradication of tumors in vivo. Citation Format: Sarit Schwartz, Brett S. Carver, John Wongvipat, Vanessa Rodrik-Outmezguine, Elisa De Stanchina, Cath Trigwell, Simon Barry, Jose Baselga, Sarat Chandarlapaty, Howard I. Scher, Charles L. Sawyers, Neal Rosen. The antitumor effects of PI3K beta inhibitors in PTEN negative prostate cancer are enhanced by inhibition of reactivated PI3K alpha signaling. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4774. doi:10.1158/1538-7445.AM2014-4774
PTX3, A Prototypical Long Pentraxin, Is an Early Indicator of Acute Myocardial Infarction in Humans
Authors: Giuseppe Peri, Martino Introna, Domenico Corradi, Giuseppe Iacuitti, Stefano Signorini, Fausto Avanzini, Fabrizio Pizzetti, Aldo P. Maggioni, Tiziano Moccetti, Marco Metra, Livio Dei Cas, Pietro Ghezzi, Jean D. Sipe, Gianpietro Re, Giorgio Olivetti, Alberto Mantovani, Roberto Latini
Journal: Circulation (2000)

Background —Inflammation is an important component of ischemic heart disease. PTX3 is a long pentraxin whose expression is induced by cytokines in endothelial cells, mononuclear phagocytes, and myocardium. The possibility that PTX3 is altered in patients with acute myocardial infarction (AMI) has not yet been tested. Methods and Results —Blood samples were collected from 37 patients admitted to the coronary care unit (CCU) with symptoms of AMI. PTX3 plasma concentrations, as measured by ELISA, higher than the mean+2 SD of age-matched controls (2.01 ng/mL) were found in 27 patients within the first 24 hours of CCU admission. PTX3 peaked at 7.5 hours after CCU admission, and mean peak concentration was 6.94±11.26 ng/mL. Plasma concentrations of PTX3 returned to normal in all but 3 patients at hospital discharge and were unrelated to AMI site or extent, Killip class at entry, hours from symptom onset, and thrombolysis. C-reactive protein peaked in plasma at 24 hours after CCU admission, much later than PTX3 ( P &lt;0.001). Patients &gt;64 years old and women had significantly higher PTX3 concentrations at 24 hours ( P &lt;0.05). PTX3 was detected by immunohistochemistry in normal but not in necrotic myocytes. Conclusions —PTX3 is present in the intact myocardium, increases in the blood of patients with AMI, and disappears from damaged myocytes. We suggest that PTX3 is an early indicator of myocyte irreversible injury in ischemic cardiomyopathy.
Atopy and immunoglobulin E concentrations in Hodgkin's disease and other lymphomas.
Authors: P L Amlot, L A Green
Journal: BMJ (1978)

Serum immunoglobulin E (IgE) concentrations are increased in Hodgkin's disease (HD) but not in other types of lymphoma. The prevalence of atopic disease is similar to normal in both groups. Patients with high IgE concentrations and HD were separated into atopic and non-atopic groups, which were found to differ clinically. Atopic patients had a significantly lower incidence of night sweats, fever, and weight loss, and treatment had no significant lasting effect on their IgE concentrations. In the non-atopic group there was a striking correlation between high IgE concentrations and a histological appearance of nodular sclerosis, particularly in the presence of night sweats, fever, and weight loss. Successful treatment in the non-atopic group led to a noticeable fall in IgE concentrations, in most cases to normal, though on relapse of the disease they rose again.
CASE OF ARM AND SHOULDER PRESENTATION IN WHICH EVISCERATION WAS PERFORMED
Authors: R. M. Mann
Journal: BMJ (1856)

for while abdominal aneurism in the female is of very rare ocurrence, inorganic aortic pulsation is very common.ju l accumulatioa and impaction has been mistaken i# aneurism of the abdominal aorta.The oval shape of the tumour, with its doughy, inelastic feel, and the result of free purgation, will, in general, suffice to clear up the gos.Enlarged glands, or organic disease of the abdominal Tiscea, either lying over, or pressing laterally upon the artery, will sometimes closely simulate aneurism.The history of the cases, and especially the existence of malig-
Diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: a study in children and young adults
Authors: Sonata Jodele, Stella M. Davies, Adam Lane, Jane Khoury, Christopher Dandoy, Jens Goebel, Kasiani Myers, Michael Grimley, Jack Bleesing, Javier El-Bietar, Gregory Wallace, Ranjit S. Chima, Zachary Paff, Benjamin L. Laskin
Journal: Blood (2014)
Effects of health publicity on prevalence of smoking
Authors: D. Reid
Journal: BMJ (1994)

cholesterolaemia is found and the decision is made to measure the low density lipoprotem cholesterol concentration.Many laboratories use an indirect measurement of this which requires knowledge of the triglyceride concentration.Consistent evidence that triglycerides have an important independent role in the prevention of coronary heart disease, however, remains elusive; calls for triglyceride testing must appeal to faith rather than established fact.
Handicapping the Handicapped
Authors: Michael J. Maricic
Journal: Annals of Internal Medicine (1992)

Letters1 December 1992Handicapping the HandicappedMichael J. Maricic, MDMichael J. Maricic, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-11-975_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: As a rheumatologist, I recently evaluated a patient with osteogenesis imperfecta, who had come for a second opinion. His enlarged bossed skull, blue sclera, and severely underdeveloped lower extremities were disturbingly distracting, even to a physician accustomed to dealing with physical deformities and who had seen such patients before.As I take a history, I usually scan the patient's visible joints, looking for signs of inflammation or deformity. With this patient, however, it was not until I was near the end of the physical examination when I felt his warm, swollen elbows, wrists, and metacarpals and noticed... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Arizona Health Science Center Tucson, AZ 85724 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1992Volume 117, Issue 11Page: 975-975KeywordsElbowInflammationSkull Issue Published: 1 December 1992 PDF DownloadLoading ...
Lumbar Puncture-Reply
Authors: Donald A. Feinfeld
Journal: JAMA (1979)

Dr Gaylord is correct about caution in performing lumbar puncture. However, not having anticipated his letter, we did not discuss the indication in our case report, since it was not germane. In fact, meningitis was seriously considered at the time, based on the following symptoms: persistent fever, an existing intracranial infection in a patient receiving corticosteroids, and an inappropriate secretion of antidiuretic hormone. Meningitis is a known cause of antidiuretic hormone secretion, and before our findings in this case were disclosed, the disease was not known to be associated with pure cavernous sinus thrombosis.
Electrocardiographic Pattern of Massive Myocardial Infarction without Pathologic Confirmation
Authors: JOSEPH J. MAMLIN, EMIL L. WEBER, CHARLES FISCH
Journal: Circulation (1964)

A case of a 67-year-old patient with an electrocardiographic pattern of a massive myocardial infarction but with a normal heart at autopsy is described. The cause of death was purulent pneumonia complicated by peripheral vascular collapse. The findings in our case simply reconfirm the well-established principle that the surface electrocardiogram mirrors the electrical phenomena of the heart, which may or may not parallel histologic changes.