tbuckley/cabot-search huggingface dataset:
A CASE OF POROKERATOSIS. *
Authors: H. Mac, C. de C. PELLIER
Journal: British Journal of Dermatology (1918)

THE case to be described presented himself at C-reneral Hospital in Aprils 1918.As the condition from which he suffered is both rare and interesting it was considered worthy of record.The man under consideration, George F-, a private soldier, aged 27 years, had at the time seen served four years in the Army.In civil life he was employed in a chemical works.The history of the complaint we give below was obtained with difficulty; the patient was both vague and uncertain in his replies, and on different occasions contradicted statements previously made.He stated he had no recollection of any former illness, or of the occurrence of skin-disease in other members of his family.The condition was noticed on the left hand some two years prior to admission into hospital, and was ascribed to a burn with vitriol in civil life.It began about the middle of the hand, spreading thence down to the fingers and up the arm and onto the chest and neck.For about one year after the onset the disease had progressed with some rapidity, after which time further extension had been slow or nesrlierible.Weakness of the left hand was also complained of.
Inflammation of Malignant Skin Involvement With Fluorouracil
Authors: R. Curtin
Journal: JAMA (1977)

<h3>To the Editor.—</h3> A localized, recurrent rash developed in a patient with cancer of the breast on three occasions during a series of injections of fluorouracil. A number of biopsy specimens, taken from apparently normal skin in the area after the eruption had subsided for the third time, showed cancer cells within small vascular channels. <h3>Report of a Case.—</h3> A 46-year-old woman underwent a modified radical mastectomy on May 9,1974. Seven of seven lymph nodes in the specimen contained cancer. By early fall she noted "blisters" in the scar; biopsy specimens of the blisters revealed recurrent carcinoma. Radiotherapy was begun on Nov 29,1974, and was completed on Jan 17,1975. From Feb 10, 1975, until early July of that year, the patient received intravenous injections of fluorouracil. A rash appeared after the second dose, and administration of the drug was withheld. Within two weeks the rash had gone, and administration of
Studies on Glucose Metabolism
Authors: A. R. P. Walker, B. D. Richardson, S. D. Mistry
Journal: BMJ (1964)

Group III.-Mitral stenosis, judged oper- able, trivial or no symptoms, and systemic embolism.With atrial fibrillation operation is advised.Sinus rhythm is uncommon ; if present we generally recommend operation.Group IV.-Systemic embolism has occurred, but closed valvotomy will not improve valve function.(a) Patients with heavily calcified disorganized valves which are probably more stenotic than incompetent.Operative embolism is a grave risk, occurring in 16% with atrial fibrillation.There is a 12% risk of post-operative emboli.An operative mortality of 13% is considerably higher than for non-calcified valves. (b) Dominant mitral incompetence. 20such patients had closed surgery, 6 died at opera- tion, and three had recurrent emboli despite atrial appendagectomy.Atrial appendagectomy alone does not pro- ,tect against future emboli, especially if valve function cannot be improved.With a heavily calcified valve, a high surgical mor- tality rate, risk of operative embolism, and limited benefit make it difficult to recommend closed surgery despite previous embolism.In this situation anticoagulant treatment might be considered.Pre-operative embolism in a random group of 104 patients in this series was no com- moner with a large than with a small appendage, as assessed radiologically.Conversely, in 105 patients with systemic embolism large appendages were as common as small appendages.Our findings differ from those of Dr. W.
Comèl-Netherton syndrome defined as primary immunodeficiency
Authors: Ellen D. Renner, Dominik Hartl, Stacey Rylaarsdam, Marguerite L. Young, Linda Monaco-Shawver, Gary Kleiner, M. Louise Markert, E. Richard Stiehm, Bernd H. Belohradsky, Melissa P. Upton, Troy R. Torgerson, Jordan S. Orange, Hans D. Ochs
Journal: Journal of Allergy and Clinical Immunology (2009)
Osteoporosis: Prevention, Management, Treatment
Authors: T C B Stamp
Journal: Annals of the Rheumatic Diseases (1990)

This is a handbook for patients, actual and potential, and for all lay readers with an interest in osteoporosis.It is written jointly by three American doctors, one a specialist, who share a Florida practice, and by one professional writer.Within its context it provides a comprehensive account of osteoporosis-what it is, how it should be managed, its risk factors, signs and symptoms, and plans for prevention and treatment from childhood to old age.It is profusely but clearly illustrated, readable, and informative.It might be argued that the benefits of high calcium intake and calcium supplementation are less well proved than the authors uncritically maintain.The minute details given of the calcium content of everything we eat might, therefore, lead to unnecessary obsessions on the patients' part.Nevertheless, the book is judicious in its recommendations for therapy and treads a fair line between accepted and experimental treatment.Other details include a simple description of quantitative computed tomography and even the exact calcium content of every 'dish' available at McDonalds and Burger King!The flavour is therefore transatlantic, and one disadvantage to British readers is the limitation of all drug names to American proprietary preparations.Despite this, it
A Role for the PI-3 Kinase Signaling Pathway in Fear Conditioning and Synaptic Plasticity in the Amygdala
Authors: Chih-Hung Lin, Shiu-Hwa Yeh, Chia-Ho Lin, Kwok-Tung Lu, Tzeng-Horng Leu, Wen-Chang Chang, Po-Wu Gean
Journal: Neuron (2001)
Cimetidine and duodenal ulcer.
Authors: K F Schiller
Journal: BMJ (1979)

in general practice, so that there are many cimetidine-treated patients in the community with undiagnosed or (if they come up to clinic during or shortly after a course of cimetidine) undiagnosable abdominal pain, some of whom may be harbouring palliated malignancy.It is necessary to emphasise, categorically, that it is in every patient's best interests to have a definitive diagnosis made before treatment with cimetidine is started.There is no doubt that the endoscopic and radiological facilities within the NHS are adequate to cope with the demand.A definitive diagnosis is all the more important since it is clear that prolonged, rather than short-term, cimetidine treatment is necessary for most of these patients with chronic duodenal ulcer disease who are suitable for medical treatment.
The Maturation of Differentiation Therapy
Authors: Bruce D. Cheson
Journal: New England Journal of Medicine (1992)

The growth of cancer cells is characterized by the blocking of normal differentiation. Nonetheless, the cytotoxic effects of standard anticancer chemotherapy are directed not only at the malignant cells but also at normal tissues. A more rational approach to treating cancer would be to use compounds that induce differentiation of human tumor cells. Such agents may act by producing a more mature phenotype, activating apoptosis (programmed cell death), or suppressing the growth of tumor cells. Unfortunately, the clinical application of this strategy is still in its infancy. One major obstacle with many agents is that the high concentrations required for . . .
Alliance and technique in short-term dynamic therapy
Authors: Paul Crits-Christoph, Mary Beth Connolly
Journal: Clinical Psychology Review (1999)

We review existing studies on the extent to which the alliance and techniques predict the outcome of short-term dynamic psychotherapy (STDP). Although the alliance has been found to relate to outcome in diverse psychotherapies, evidence for its role in STDP is more inconsistent. Studies of technique factors have provided support for the relation of competence with exploratory interventions to outcome. Less support for the role of specific transference interpretations was found. Little empirical support exists for the notion that the technical factors are most potent in the context of a positive alliance, although adequate studies of this interaction are scarce. Similarly, adequate studies that attempt to tease apart the extent to which technical factors influence the alliance, and vice versa, are also rare. Despite the methodological limitations of research in this area, the fact that there are some consistent findings relating techniques to outcome suggests that nonspecific relationship factors do not by themselves account for the changes found over the course of STDP. Moreover, such findings encourage additional efficacy and process research on STDP. Some suggestions for future research are presented.
COMMENTS ON THE USE OF RADIUM FOR INTRA-ORAL CANCER
Authors: ALBERT SOILAND
Journal: JAMA (1924)

<h3>Cancer involving any part of the intra-oral structures should always be looked on with great concern, for nowhere in the human organism is it more imperative to institute early and drastic action if expect clinical cures. Within the mouth, there seem to certain locations that are more responsive to treatment than others, and, from my own observations, it appears that among the hopeful ones are those neoplasms which originate in the gum or soft alveolar tissues, and which are so located in the mouth as to be easily accessible both to inspection and to treatment.</h3> THE FLOOR OF THE MOUTH The floor of the mouth, particularly that part lying anterior and under the tongue, shows a kindly reaction to radium when it is used with care and judgment. In this region, one frequently finds nests of cancerous cells growing by extension from a primary lesion of the gum or the
NOTES ON ONE HUNDRED AND FIFTY CASES OF SMALLPOX IN PRIVATE PRACTICE.
Authors: ALBERT SOILAND
Journal: JAMA (1901)

There exists some diversity of opinion among members of our profession regarding the true nature of the disease which has been rather epidemic in some sections of our country during the last few years, and which has been termed by the various writers variola, modified smallpox, pseudo-smallpox, varicella, Cuban itch, elephant itch, Philippine rash, etc. It is true that the great majority of physicians recognize this disease as genuine smallpox; yet there are a number of careful observers who will not admit that such is the case, but who insist that this is a new unclassified disease; others again hold that it is an unusually severe type of chickenpox. During the past twelve months I have had the opportunity to observe and treat 150 cases of this disease, as they occurred in private practice, principally among the negroes, in Central Louisiana, and I do not hesitate to state that these
Meningitis B vaccine looks promising
Authors: T. Sheldon
Journal: BMJ (1998)

Dutch researchers believe that they have found an effective vaccine to combat group B meningococcal disease, which is responsible for about 500 cases of bacterial meningitis in the Netherlands each year.

Preliminary results of clinical trials with the new vaccine are encouraging, according to Dr Eileene Rouppe van der Voort of Amsterdam's Free University. Large scale production of the vaccine is under way at the Dutch National Institute for Public Health …
Sports utility vehicles and older pedestrians
Authors: Ediriweera B R Desapriya, Ian Pike
Journal: BMJ (2005)

The chief determinants for the degree of severity of injuries in motor vehicle collisions are vehicle size and weight. If all cars were designed to be equal in standard to the best car currently available in each class, then an estimated half of all fatal and disabling injuries could be avoided. Sports utility vehicles (SUVs) differ from cars in three key areas: they have greater mass and stiffness and the geometry places bumpers above the frames of struck cars, resulting in higher intrusion when striking smaller cars. Thus the safety designs that were effective 10 or 15 years ago are not adequate in today's incompatible vehicle collisions. New technology needs to be developed and implemented. Although mass affects survival in crashes, good vehicle geometry and energy absorbing interfaces are important in developing a heavy vehicle that behaves in crashes like the average car.
1344 POLYMORPHISM (SNP) RS12979860 OF IL28B IN MEXICAN PATIENTS WITH CHRONIC HEPATITIS C AND ITS ASSOCIATION WITH VIROGICAL RESPONSE TO PEG-IFN ALPHA 2B AND RIBAVIRIN
Authors: S. Sixtos-Alonso, R. Avalos-Martinez, M. Dehesa-Violante, R. Sandoval-Salas, A. Chavez-Ayala, I. Garcia-Juarez, A. Dominguez-Lopez, F. Vargas-Vorackova, J.F. Sanchez-Avila, M. Uribe
Journal: Journal of Hepatology (2011)
Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity
Authors: Felix C. Weber, Tamás Németh, Janka Z. Csepregi, Anne Dudeck, Axel Roers, Béla Ozsvári, Eva Oswald, László G. Puskás, Thilo Jakob, Attila Mócsai, Stefan F. Martin
Journal: The Journal of Experimental Medicine (2014)

Allergic contact dermatitis and its animal model, contact hypersensitivity (CHS), are T cell–mediated inflammatory skin diseases induced by contact allergens. Though numerous cellular and molecular players are known, the mechanism of chemical-induced sensitization remains poorly understood. Here, we identify neutrophils as crucial players in the sensitization phase of CHS. Genetic deficiency of neutrophils caused by myeloid-specific deletion of Mcl-1 or antibody-mediated depletion of neutrophils before sensitization abrogated the CHS response. Neutrophil deficiency reduced contact allergen-induced cytokine production, gelatinase release, and reactive oxygen species production in naive mice. Mast cell deficiency inhibited neutrophil accumulation at the site of sensitization. In turn, neutrophils were required for contact allergen-induced release of further neutrophil-attracting chemokines, migration of DCs to the draining lymph nodes, and priming of allergen-specific T cells. Lymph node cells from mice sensitized in the absence of neutrophils failed to transfer sensitization to naive recipients. Furthermore, no CHS response could be induced when neutrophils were depleted before elicitation or when normally sensitized lymph node cells were transferred to neutrophil-deficient recipients, indicating an additional role for neutrophils in the elicitation phase. Collectively, our data identify neutrophils to be critically involved in both the sensitization and elicitation phase of CHS.
Underdetection of ventricular tachycardia by algorithms to enhance specificity in a tiered-therapy cardioverter-defibrillator
Authors: Charles D. Swerdlow, Thomas Ahern, Peng-Sheng Chen, Chun Hwang, Eli Gang, William Mandel, Robert M. Kass, C.Thomas Peter
Journal: Journal of the American College of Cardiology (1994)
Ventilation and Perfusion Imaging in Swyer-James Syndrome
Authors: LOUIS S. ZEIGER, EDWARD G. MOSS
Journal: Clinical Nuclear Medicine (1977)

The use of ventilation and perfusion scans in the syndrome of the Swyer-James syndrome is discussed. A typical case is presented of an 18-year-old black man with a history of recurrent dyspnea who came to medical attention because of the x-ray appearance of the “small hyperlucent lung.” The perfusion scan (99 mTc-MAA) showed an absence of perfusion to the ipsilateral lung. Ventilation imaging showed a severe reduction of alveolar ventilation to the entire lung except the upper lobe with delayed washout. Additional radiographic studies such as inspiratory-expiratory chest x-rays point toward minimal air trapping in the ipsilateral side. Pulmonary angiography demonstrated atrophic vessels to the affected area of the right lung. Bronchography shows a diffuse bronchiolitis obliterans pattern typical of the Swyer-James Syndrome on the affected side.
HIV Infection in Vaccinated Volunteers
Authors: Dani P. Bolognesi
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Recent reports in the lay press revealed that eight of more than 1400 volunteers participating in phase I and II human immunodeficiency virus (HIV) vaccine studies being conducted by the AIDS Vaccine Clinical Trials Network sponsored by the National Institute of Allergy and Infectious Diseases have developed intercurrent infection with HIV-1. Because the vaccines tested to date consist only of the gp120 protein and not reverse transcriptase or other components necessary for viral replication, and are products produced by recombinant DNA technology or chemical peptide synthesis, it is not possible to acquire HIV infection from the vaccines.<sup>1</sup>The occurrence of HIV infection among volunteers, particularly those who may engage in high-risk behavior, is not unexpected. In studies of vaccines against other diseases, intercurrent infection often occurs. It is important for physicians and other health care workers to be aware of the facts so they can answer
Herpangina
Authors: Robert H. Parrott, Sidney Ross, Frederic G. Burke, E. Clarence Rice
Journal: New England Journal of Medicine (1951)

FOR many past summers, a disease entity characterized by fever with vesicular or ulcerated throat lesions and chiefly affecting children has been prevalent in the District of Columbia and its environs. During the summer of 1950 it became widely disseminated, assuming epidemic proportions during July and August. There was general agreement among the physicians practicing in these areas that the disease made its appearance with some regularity each summer, was highly contagious and usually ran a benign, self-limited course. It is now apparent that this disease was herpangina, a specific entity described by Zahorsky1 , 2 in 1920. Very few reports on . . .
THE INFLUENCE OF ANTITOXIN UPON THE ACTION OF CLOSTRIDIUM OEDEMATIENS TOXIN IN THE HEART-LUNG PREPARATION OF THE DOG 123
Authors: Otto Krayer, Joseph C. Aub, Ira T. Nathanson, Paul C. Zamecnik
Journal: Journal of Clinical Investigation (1947)

Previous experiments (1) have indicated that Cl. oedematiens toxin produces types of dynamic effects similar to those seen in traumatic shock.Blood volume was not diminished to the same ex- tent as in hemorrhagic shock, but the peripheral vascular resistance rose and the cardiac output was reduced in the characteristic manner.It was not obvious, in the intact dog, whether these difficulties arose in the peripheral circulation or in the heart.Wiggers (2) has discussed a similar type of prob- lem with reference to shock.Thus, in order to evaluate more specifically the factors involved in the circulatory failure resulting from Cl. oede- matiens toxin, the heart-lung preparation has been utilized.
RADIATION PROTECTION IN FORTY-FIVE HOSPITALS
Authors: LEONARD A. SCHEELE
Journal: JAMA (1941)

The increasing use of radiation in medicine, industry and research demands increased knowledge of radiation effects and protection methods. The authors visited forty-five hospitals of all types, ranging in size from forty-four to over three thousand beds (thirty-two have more than two hundred beds) and studied storage and handling of radium, calibration and shielding of roentgen therapy equipment and technics of use and shielding of roentgenographic and fluoroscopic units. Ionization chambers ranging in sensitivity from 0.25 roentgen to 100 roentgens full scale were used in making measurements. Estimates of average exposures were calculated from ionization measurements made during typical operations such as preparation of radium applicators and roentgenoscopic and roentgenographic procedures, multiplied by the average daily time spent performing such activities. Adequacy of equipment and practices were judged in most instances on the basis of recommendations for protection which have been published by various writers<sup>1</sup>and those in the
Diagnosis and Early Management of Acute Psychosis
Authors: William H. Anderson, John C. Kuehnle
Journal: New England Journal of Medicine (1981)

THE term "acute psychosis" denotes a group of medical disorders characterized by a diminished and distorted capacity to process information. In some cases the cause is a recognized physiologic abnormality of brain function. Such cases may be called "delirium" or "acute brain syndrome" and are typically associated with fluctuating levels of consciousness, disorientation, and recent memory deficit.1 In other cases the cause is unknown. The defect in information processing is present, but the abnormality in brain physiology cannot be identified by currently available means. These cases are generally called "acute functional psychosis," or more specifically "acute schizophrenia" or "acute mania," . . .
Polyneuritis After Exposure to Dinitro-ortho-Cresol
Authors: H. Stott
Journal: BMJ (1956)

Although polyneuritis is known to occur as the result of exposure to certain of the aromatic carbon compounds such as benzene, dinitrobenzene, dinitrotoluene, and trinitrotoluene there does not appear to be any record of its occurrence among persons exposed to dinitro- ortho-cresol (D.N.O.C.).Nadler (1935) has, however, recorded two cases of peripheral neuritis caused by dinitrophenol (D.N.P.) given therapeutically for the treatment of obesity.As D.N.P. and D.N.O.C. are not only chemically closely allied but exert a similar physio- logical action on the living cell, it is not unreasonable to suppose that D.N.O.C. also might cause similar neuro- logical complications.Two cases of polyneuritis have been observed, and are described here, among staff who were servicing aircraft which were being used for spray- ing D.N.O.C. on locust swarms.Case 1 A male native Mkamba, aged about 47, had been engaged continually for two months on checking and cleaning the jets on the spray booms of aircraft spraying a 20% solution of D.N.O.C. in oil.He was working in hot and arid areas of Kenya and Tanganyika, and, in spite of regulations to the contrary, he had been wearing no protective clothing of any sort.He stated that he washed his hands invariably before
Outcomes of donor evaluation in adult-to-adult living donor liver transplantation
Authors: James F. Trotter, Karen A. Wisniewski, Norah A. Terrault, James E. Everhart, Milan Kinkhabwala, Robert M. Weinrieb, Jeffrey H. Fair, Robert A. Fisher, Alan J. Koffron, Sammy Saab, Robert M. Merion
Journal: Hepatology (2007)

The purpose of donor evaluation for adult-to-adult living donor liver transplantation (LDLT) is to discover medical conditions that could increase the donor postoperative risk of complications and to determine whether the donor can yield a suitable graft for the recipient. We report the outcomes of LDLT donor candidates evaluated in a large multicenter study of LDLT. The records of all donor candidates and their respective recipients between 1998 and 2003 were reviewed as part of the Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL). The outcomes of the evaluation were recorded along with demographic data on the donors and recipients. Of the 1011 donor candidates evaluated, 405 (40%) were accepted for donation. The donor characteristics associated with acceptance (P < 0.05) were younger age, lower body mass index, and biological or spousal relationship to the recipient. Recipient characteristics associated with donor acceptance were younger age, lower Model for End-stage Liver Disease score, and shorter time from listing to first donor evaluation. Other predictors of donor acceptance included earlier year of evaluation and transplant center. Conclusion: Both donor and recipient features appear to affect acceptance for LDLT. These findings may aid the donor evaluation process and allow an objective assessment of the likelihood of donor candidate acceptance. (HEPATOLOGY 2007.)
Hepatic Adenoma Demonstration of Discordant Uptake with Tc-99m Sulfur Colloid and Tc-99m DISIDA
Authors: LAWRENCE M. VINCENT, TAE HYON RHO, WILLIAM H. McCARTNEY, MATTHEW A. MAURO
Journal: Clinical Nuclear Medicine (1984)

Scintigraphic images demonstrate extensive discordant uptake of Tc-99m SC and Tc-99m DISIDA in a patient with a large hepatic adenoma.