tbuckley/cabot-search huggingface dataset:
Lupus Erythematosus: Immunosuppressive Therapy
Authors: E. V. BARNETT
Journal: Annals of Internal Medicine (1976)

Comments and Correction1 May 1976Lupus Erythematosus: Immunosuppressive TherapyE. V. BARNETT, M.D.E. V. BARNETT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-5-610_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I wish to contradict the pessimistic impression placed on combination therapy and to emphasize that there is a great deal of anecdotal and controlled data supporting a clinical synergism for corticosteroids and cytotoxic drugs. We all agree that their use should continue to be investigational. I emphasize that the investigational design should include dosage schedules that avoid the toxic effects of both drugs and not include patients with persistent uremia. Your journal's recent reports (1, 2) and accompanying editorial (3) on the immunosuppressive therapy in lupus erythematosus fail to explain the improved survival of patients treated in...References1. HAHNKANTOROSTERLAND BOC: Azathioprine plus prednisone compared with prednisone alone in the treatment of systemic lupus erythematosus. Ann Intern Med 83:597-605, 1975 LinkGoogle Scholar2. DECKERKLIPPELPLOTZ JJP: Cyclophosphamide or azathioprine in lupus glomerulonephritis. Ann Intern Med 83:606-615, 1975 LinkGoogle Scholar3. ROTHFIELD N: Immunosuppressive therapy in lupus erythematosus. Ann Intern Med 83:727-728, 1975 LinkGoogle Scholar4. DRINKARDSTANLEYDORNFIELD JTL: Azathioprine and prednisone in the treatment of adults with lupus nephritis. Medicine (Baltimore) 49:411-432, 1970 CrossrefMedlineGoogle Scholar5. DORNFELDPEARSONGONICK LCH: Long-term follow-up of systemic lupus erythematosus glomerulonephritis treated with prednisone and azathioprine. Presented at the 13th International Congress of Rheumatology, 30 September 1973, Tokyo, Japan Google Scholar6. BARNETT E: Action of immunosuppressive drugs. Dialysis Transplant 4:38-39, 1975 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine UCLA Medical School Los Angeles, CA 90024 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1976Volume 84, Issue 5Page: 610-610KeywordsCorticosteroid therapyDrug therapyDrugsImmunosuppressivesLupus erythematosus Issue Published: 1 May 1976 PDF DownloadLoading ...
Queries and Minor Notes.
Authors: Thomas F. Harrington
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE EFFECT OF TRANQUILLIZERS ON SOME ASPECTS OF THE TREATMENT OF LONG STAY PATIENTS
Authors: A. A. ROBIN
Journal: American Journal of Psychiatry (1963)

A retrospective study of a long stay population from 1952-58 shows the patients chosen for tranquillizers in the long stay group are those with the best outlook as far as discharge is concerned. Nevertheless, tranquillized long stay patients when compared with non-tranquillized patients do nothave a better prospect of discharge and may indeed to some extent have a lesser prospect. Hospitaltreatment with tranquillizers does not alter the chance of re-admission of discharged long stay patients. Ward behaviour, apart from some aspects of "disturbance," is little influenced by tranquilizers which are themselves possibly associated with the introduction of new symptoms. Disturbed wards invite treatment and on them, as on other wards, tranquillizers have replaced other sedatives, with the numbers of patients ultimately treated exceeding the numbers previously sedated.
A Biopsychosocial Model of Interferon-Alpha-Induced Depression in Patients with Chronic Hepatitis C Infection
Authors: Andreas Baranyi, Andreas Meinitzer, Alexandra Stepan, Csilla Putz-Bankuti, Robert J. Breitenecker, Rudolf Stauber, Hans-Peter Kapfhammer, Hans-Bernd Rothenhäusler
Journal: Psychotherapy and Psychosomatics (2013)

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; The aim of this prospective study was to gain a more comprehensive picture of the biopsychosocial effects of interferon-α (IFN-α) treatment of patients with chronic hepatitis C (HCV). The predictors of depressive development and changes in health-related quality of life, life satisfaction and cognitive ability were measured with the inclusion of the social context. Furthermore, the effects of IFN-α treatment on indoleamine 2,3-dioxygenase, the level of tryptophan supply in the brain, the development of neurotoxic kynurenine metabolites and the thyroid glands were investigated. Therefore, for the first time the conditions for the development of depressive episodes in HCV patients treated with IFN-α were examined over the entire period of treatment as well as 3 months later, applying a holistic biopsychosocial model. &lt;b&gt;&lt;i&gt;Method:&lt;/i&gt;&lt;/b&gt; Psychiatric and biological assessments were carried out at 6 different times: before, during (at 1, 3, 6 and 9 months) and after the end of IFN-α treatment. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; During IFN-α treatment 22 (53.7%) of 41 patients fulfilled the criteria for a treatment-related depressive disorder at least once during treatment. Contributing factors are tryptophan depletion (tryptophan to competing amino acids quotient), increased neurotoxic challenge (kynurenine to kynurenic acid quotient), less social support, female gender, preexisting psychiatric vulnerability, means of transmission, low financial security, impaired sexual satisfaction, small circle of friends, impaired physical role, strong body pain, low general health and vitality, reduced social functioning, impaired mental health and impaired emotional role. &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; The awareness of relevant risk factors of IFN-α treatment-induced depression is essential to develop preventative treatment strategies.
Upper gastrointestinal tumors
Authors: K. Tytgat
Journal: Endoscopy (2009)

Fundic gland polyps (FGP) are known to occur with familial adenomatous polyposis coli. When they occur in a patient with no known history of familial polyposis, they are called “sporadic.” Some small European studies have reported a possible association between FGPs and colonic adenomas or even carcinomas, suggesting that every patient with sporadic FGP should undergo colonic surveillance [2]; and even we tell our trainees to biopsy at least one or the largest FGP to define a histopathologic diagnosis. Therefore, it is interesting to read this large retrospective study, designed and carried out in a diagnostic pathology center, which denies this association.
THE SOURCE OF FREE AMINO ACIDS IN KERATIN SCRAPINGS.
Authors: G. B. DOWLING, P. F. D. NAYLOR
Journal: British Journal of Dermatology (1960)

Journal Article THE SOURCE OF FREE AMINO ACIDS IN KERATIN SCRAPINGS. Get access G. B. DOWLING, G. B. DOWLING Department of Medicine, St. Thomas's Hospital Medical School, and Department of Dermatology, St. Thomas's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar P. F. D. NAYLOR P. F. D. NAYLOR Department of Medicine, St. Thomas's Hospital Medical School, and Department of Dermatology, St. Thomas's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 72, Issue 2, 1 February 1960, Pages 57–61, https://doi.org/10.1111/j.1365-2133.1960.tb13845.x Published: 01 February 1960
Immunologic properties of bacterial lipopolysaccharide (LPS). II. The unresponsiveness of C3H/HeJ Mouse spleen cells to LPS-induced mitogenesis is dependent on the method used to extract LPS.
Authors: B J Skidmore, D C Morrison, J M Chiller, W O Weigle
Journal: The Journal of Experimental Medicine (1975)

The C3H/HeJ mouse strain, previously shown to be a nonresponder to bacterial lipopolysaccharide (LPS)-induced mitogenesis in vitro, was demonstrated by the present studies to be competent to respond mitogenically to LPS, but only to LPS preparations obtained by selected extraction methods. These preparations appear to be confined to LPS isolated by mild extraction techniques, such as TCA or butanol. In contrast, those obtained by techniques utilizing phenol were only weakly stimulatory or completely nonstimulatory for spleen cells from the C3H/HeJ. All LPS preparations tested, on the other hand, were highly stimulatory for cells from another mouse strain, namely the C3H/St. The critical importance of the method of extraction of LPS on its mitogenic activity for C3H/HeJ cells was stressed by experiments in which LPS was prepared from Escherichia coli K235 using either of two procedures. In these experiments, phenol-extracted LPS, although mitogenic in the C3H/St, was completely nonstimulatory in the C3H/HeJ; whereas, butanol-extracted LPS was highly stimulatory in both strains of mice. This striking difference was attributed to a destructive effect of phenol on LPS, as demonstrated by the fact that treatment of butanol LPS with phenol resulted in a total loss of its mitogenic activity in the C3H/HeJ, but in only a partial loss in the C3H/St. In general, the mitogenic response observed with selected LPS preparations in the C3H/HeJ was quantitatively lower and more transient than that seen with the C3H/St, although qualitatively these responses appeared to be similar. This was evidenced by the observation that in both mouse strains LPS was a specific mitogen for B cells, a property which was also attributed in both strains to the same distinct structural region of the LPS molecule, that is lipid A. A preparation of LPS that failed to stimulate B cells from the C3H/HeJ nonetheless had the capacity to block activation of these B cells by a stimulatory preparation of LPS. These results strongly suggest that mitogenic stimulation of B cells by LPS is a function of the structural integrity of both the LPS molecule and putative B-cell receptors for LPS.
Insufficient support for either response “priming” or “program-level imitation”
Authors: Thomas R. Zentall
Journal: Behavioral and Brain Sciences (1998)

Byrne &amp; Russon propose that priming can account for the imitation of simple actions, but they fail to explain how the behavior of another can prime the observer's own behavior. They also propose that imitation of complex skills requires a sequence of acts tied together by a program, but they fail to rule out the role of trial-and-error learning and perceptual/motivational mechanisms in such task acquisition.
A Psychological Analysis of the Munchausen Syndrome: Request for Information
Authors: J. C. Barker, T. G. Grygier
Journal: BMJ (1958)

SERUM CONTAINING THREE Rh ANTIBODIES Mpresent only in such small amounts as to be removed non- specifically by absorption.The combination of the three antibodies found does not appear to have been described before.It could arise by ordinary immunization only in a person of the rare geno- type cdE/cdE.It is, moreover, interesting to note that only donors of this genotype would have been compatible with this patient, who belonged to the commonest of all Rh phenotypes.He had antibodies against three of his own four main Rh antigens. SummaryThe serum of an untransfused patient of Rh phenotype CcDee (probable genotype CDe/cde) suffering from chronic leukaemia and secondary haemolytic anaemia was found to contain the Rh antibodies anti-C, anti-D, and anti-e.REFERENCES
Acute Myocardial Infarction: Home and Hospital Treatment
Authors: H. G. Mather, N. G. Pearson, K. L. Q. Read, D. B. Shaw, G. R. Steed, M. G. Thorne, S. Jones, C. J. Guerrier, C. D. Eraut, P. M. McHugh, N. R. Chowdhury, M. H. Jafary, T. J. Wallace
Journal: BMJ (1971)

This is a preliminary report of a co-operative study of 1,203 episodes of acute myocardial infarction in men under 70 years in four centres in the south west of England. The mortality at 28 days was 15%. A comparison is made between home care by the family doctor and hospital treatment initially in an intensive care unit: 343 cases were allocated at random. The randomized groups do not differ significantly in composition with respect to age; past history of angina, infarction, or hypertension; or hypotension when first examined. The mortality rates of the random groups are similar for home and hospital treatment. The group sent electively to hospital contained a higher proportion of initially hypotensive patients whose prognosis was bad wherever treated; those who were not hypotensive fared rather worse in hospital. For some patients with acute myocardial infarction seen by their general practitioner home care is ethically justified, and the need for general admission to hospital should be reconsidered.
Visual Outcome after Proton Beam Irradiation of Uveal Melanoma
Authors: Johanna M. Seddon, Evangelos S. Gragoudas, Lela Polivogianis, Chung-Cheng Hsieh, Kathleen M. Egan, Michael Goitein, Lynn Verhey, John Munzenrider, Mary Austin-Seymour, Marcia Urie, Andreas Koehler
Journal: Ophthalmology (1986)
Treatment for Hemophilia: Gene Therapy vs Transplantation-Reply
Authors: Jay Nelson Lozier
Journal: JAMA (1994)

In Reply.  —Drs Fung and Lo appropriately call attention to transplantation of organs or tissues, including embryonic and fetal tissues that may express antihemophilic proteins, as a way that may lead to a cure for the hemophilias. It has been nearly 27 years since organ transplantation was first used for gene therapy in hemophilia.1Transplantation of the spleen resulted in elevation of plasma factor VIII levels sufficient to change the phenotype from severe to mild in a canine model of hemophilia A. Liver transplantation was more effective, normalizing or nearly so the factor VIII levels. Over the next 20 years, several patients, as well as hemophilic dogs, were cured of both hemophilia A and hemophilia B by this mode of gene therapy using the wild-type hemophilia genes.  With the advent of hepatic cell transplantation, we have examined the feasibility of this mode of allogenic liver cell transfer in the
Na+/H+ exchangers, NHE-1 and NHE-3, of rat intestine. Expression and localization.
Authors: C Bookstein, A M DePaoli, Y Xie, P Niu, M W Musch, M C Rao, E B Chang
Journal: Journal of Clinical Investigation (1994)

Na-H exchange (NHE) is one of the major non-nutritive Na absorptive pathways of the intestine and kidney. Of the four NHE isoforms that have been cloned, only one, NHE-3, appears to be epithelial specific. We have examined the regional and cellular expression of NHE-3 in the rat intestine. NHE-3 message in the small intestine was more abundant in the villus fractions of the small intestine than in the crypts. Analysis of NHE-3 mRNA distribution in the gut by in situ hybridization demonstrated epithelial cell specificity, as well as expression preferential to villus cells. NHE-1 message, in contrast, was ubiquitous, with slightly greater expression exhibited in the differentiating crypt and lower villus cells of the small intestine. Isoform-specific NHE-3 fusion protein antibody identified a 97-kD membrane protein in the upper villus cells of the small intestine, which was exclusively localized in the apical membrane. In contrast, antibody previously developed against the COOH-terminal region of human NHE-1 (McSwine, R. L., G. Babnigg, M. W. Musch, E. B. Chang, and M. L. Villereal, manuscript submitted for publication) identified a 110-kD basolateral membrane protein. These data suggest that unlike NHE-1, which probably serves a "housekeeping" function, NHE-3 may be involved in vectorial Na transport by the intestine.
Digital Assessment of Endothelial Function and Ischemic Heart Disease in Women
Authors: Yasushi Matsuzawa, Seigo Sugiyama, Koichi Sugamura, Toshimitsu Nozaki, Keisuke Ohba, Masaaki Konishi, Junichi Matsubara, Hitoshi Sumida, Koichi Kaikita, Sunao Kojima, Yasuhiro Nagayoshi, Megumi Yamamuro, Yasuhiro Izumiya, Satomi Iwashita, Kunihiko Matsui, Hideaki Jinnouchi, Kazuo Kimura, Satoshi Umemura, Hisao Ogawa
Journal: Journal of the American College of Cardiology (2010)
Abstract 2059: The role of microRNA-196b in cervical cancer
Authors: Christine How, Angela B. Hui, Anthony W. Fyles, Fei-Fei Liu
Journal: Cancer Research (2010)

Abstract Introduction: MicroRNAs (miRs) are ∼22-nucleotide, non-coding RNAs that regulate gene expression post-transcriptionally. Recent data have indicated that miRs are aberrantly expressed in almost all human malignancies, including cervical cancer. In order to better understand how miRs might mediate tumor progression in cervical cancer, dysregulated miRs were identified and functional studies performed for miR-196b. Experimental Procedures: miR expression was measured in 3 cervical cancer cell lines (SiHa, ME-180 and HT3) and 3 normal cervix tissues using a quantitative real-time PCR approach examining 365 miRs and 3 endogenous controls. SiHa cells were transfected with Pre-miR miRNA Precursor Molecules (Ambion) to determine the effects of miR-196b overexpression. Candidate miR-196b targets were elucidated using a tri-pronged approach combining in silico target prediction algorithms, clinical mRNA expression data, and in vitro mRNA expression data following transfection of cell lines. To test for direct binding of miR-196b to the HOXB7 3’ UTR, a luciferase reporter assay was performed. Reporter vectors were constructed containing either the HOXB7 3’ UTR sequence (pMIR-REPORT-HOXB7/UTR), or the HOXB7 3’ UTR sequence with a mutation in the predicted miR-196b binding site (pMIR-REPORT-HOXB7/mut). SiHa cells were serially transfected with: a) miR-196b pre-miR or negative control pre-miR, and b) pMIR-HOXB7/UTR or pMIR-HOXB7/mut, and luciferase activity was measured 24 hours later. To determine the effect of knocking down HOXB7, SiHa cells were transfected with siHOXB7 (Qiagen). Results: Twenty-seven miRs were observed to be downregulated in all three cell lines compared to normal cervix. One of the 27 downregulated miRs, miR-196b, was shown to inhibit cell growth and colony-forming ability when overexpressed in SiHa cells. HOXB7 was identified as one of the candidate targets of miR-196b using our tri-pronged approach. Knocking down HOXB7 recapitulated the inhibition in cell growth and clonogenicity that was observed following mir-196b overexpression. When the luciferase reporter assay was performed, miR-196b overexpression resulted in a significant reduction in luciferase activity in cells transfected with pMIR-HOXB7/UTR, but not in cells transfected with pMIR-HOXB7/mut, demonstrating direct and specific binding of miR-196b to the 3’ UTR of HOXB7. Conclusion: miR-196b is downregulated in cervical cancer and negatively regulates HOXB7. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2059.
PROGRESS IN OBSTETRICS.
Authors: Frank A. Stahl
Journal: JAMA (1899)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expression of Forkhead box P3 isoforms in hepatocellular carcinoma cells
Authors: George Chen, Jianwei Ren, Rocky Ho, Paul Lai
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Forkhead box P3 (FOXP3) is well known as a key regulator of immune homeostasis. The abnormal expression of FOXP3 can contribute to features of several cancers including metastasis and invasion, and it has also been associated with prognosis of some cancers. However, little
German doctors reject new draft bill on living wills for being too complicated
Authors: A. Tuffs
Journal: BMJ (2008)

Hopes that a long awaited draft bill on living wills will soon be passed in Germany were dashed last month when a new draft was published that would not recognise existing living wills.

In 2003 the German Constitutional Court demanded a new law to clarify the use of living wills. However, the latest draft of the bill, which is supported by a group of MPs from four of the five parties in parliament, does not automatically accept people’s existing living wills. Instead, in contrast to a former draft drawn up in September 2007, the bill demands further conditions in certain cases, such as counselling from a doctor and the agreement of a …
TEMPORARY AND PERMANENT MYXEDEMA FOLLOWING TREATED AND UNTREATED THYROTOXICOSIS 1
Authors: Willard Owen Thompson, Phebe K. Thompson
Journal: Journal of Clinical Investigation (1928)

Although myxedema following treatment for toxic goiter has been reported frequently before, we wish to call attention to certain of its aspects which we regard as particularly worthy of emphasis, viz., (a) the existence of two types-temporary and permanent, (b) the rarity of the permanent type, (c) its late onset after x-ray therapy, (d) its occurrence following untreated toxic goiter.The permanent type will be considered first. I. PERMANENT MYXEDEMA FOLLOWING TREATED THYROTOXICOSISA. Rarity In the pioneer days of goiter surgery, when thyroidectomies were usually complete, post-operative myxedema was very common, occurring in at least 33 per cent of the cases thus treated.4It was noted, however, that when thyroidectomies had been partial the incidence was only 1 per cent (1).The latter method soon supplanted the former, with the result that permanent myxedema became, and in general has remained, a practically negligible sequel to the surgical treatment of goiter.Judd (2), in observations on the surgery of the thyroid states "In our series of cases we have not observed a permanent post-operative