tbuckley/cabot-search huggingface dataset:
901-109 Value of Visualizing Atherosclerotic Plaques on the Thoracic Aorta by Transesophageal Echocardiography in Conjunction with Pharmacologic Stress
Authors: Magdy lsmaeil, Theodor Trusevich, Shashikumar Bellur, Sheri Y. Nottestad, R. Stefan Kiesz, Fathy Maklady, Miguel Zabalgoitia
Journal: Journal of the American College of Cardiology (1995)
Mortality in Patients With Hypovolemic Shock Treated With Colloids or Crystalloids
Authors: Christian Brun-Buisson, Junfeng Sun, Charles Natanson
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Change from Specialist to Generalist
Authors: Douglas M. De Long
Journal: Annals of Internal Medicine (1995)

Letters15 April 1995Change from Specialist to GeneralistDouglas M. De LongDouglas M. De LongSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-8-199504150-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Christakis and colleagues [1] reported on the “specialist” to “generalist” transformation. Please forgive me for tilting at windmills, but my button has been pushed one too many times. Yes, a disclaimer (buried in the methods section) defines a generalist as “technically” a specialist, but in this time of introspection within internal medicine, this nomenclature fosters the inappropriate image of the rank-and-file internist as second class.Particularly in rural internal medicine, where I believe the essence of our specialty still survives, being an internist is enough of a label. Rural internists provide consultative services to family practice and ...REFERENCE1. Christakis NA, Jacobs JA, Messikomer CM. Change in self-definition from specialist to generalist in a national sample of physicians. Ann Intern Med. 1994; 121:669-75. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1995Volume 122, Issue 8Page: 635-636KeywordsEmergency departmentHealth careIntensive care unitsPrimary careSub-specialty careTraditional medicine Issue Published: 15 April 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
The biochemical effects of physiologic amounts of dietary boron in animal nutrition models.
Authors: C D Hunt
Journal: Environmental Health Perspectives (1994)

This review summarizes evidence that supports working hypotheses for the roles of boron in animal model systems. It is well established that vascular plants, diatoms, and some species of marine algal flagellates have acquired an absolute requirement for boron, although the primary role of boron in plants remains unknown. Recent research findings suggest that physiologic amounts of supplemental dietary boron (PSB) affect a wide range of metabolic parameters in the chick and rat model systems. Much of the current interest in boron animal nutrition began with the initial finding that PSB stimulates growth in cholecalciferol (vitamin D3)-deficient chicks, but does not markedly affect growth in chicks receiving adequate vitamin D3 nutriture. The finding suggests that boron affects some aspect of vitamin D3 metabolism or is synergistic with vitamin D3 in influencing growth. Vitamin D3 regulates energy substrate utilization, and current research findings indicate that dietary boron modifies that regulatory function. The concentration of circulating glucose, the most thoroughly investigated metabolite to date, responds to PSB, especially during concomitant vitamin D3 deficiency. In chicks, PSB substantially alleviated or corrected vitamin D3 deficiency-induced elevations in plasma glucose concentrations. The influence of vitamin D3 on cartilage and bone mineralization is mediated in part through its role as a regulator of energy substrate utilization; calcification is an energy-intensive process. There is considerable evidence that dietary boron alleviates perturbations in mineral metabolism that are characteristic of vitamin D3 deficiency. In rachitic chicks, PSB alleviated distortion of the marrow sprouts of the proximal tibial epiphysial plate, a distortion characteristic of vitamin D3 deficiency.(ABSTRACT TRUNCATED AT 250 WORDS)
PRE-EXISTING LEFT VENTRICULAR DYSFUNCTION IN PATIENTS UNDERGOING KIDNEY TRANSPLANTATION: IMPLICATIONS FOR PATIENT SELECTION, CARDIAC RISK STRATIFICATION AND IMPACT ON POST TRANSPLANT OUTCOMES
Authors: Joseph Chattahi, Vanji Karthikeyan, Haitham Kanneh, Jayanth Koneru, Sylvia Hayek, Anita Patel, Mariella Goggins, Karthikeyan Ananthasubramaniam
Journal: Journal of the American College of Cardiology (2010)
Pre-clinical validation of a humanized anti-EGFR variant III chimeric antigen receptor and phase I trial of CART-EGFRvIII in glioblastoma
Authors: Laura A Johnson, John Scholler, Takayuki Ohkuri, Akemi Kosaka, Prachi R Patel, Shannon E McGettigan, Arben Nace, Pramod Thekkat, Andreas Loew, Taylor J Chen, Joseph A Fraietta, Avery D Posey, Alina C Boesteanu, Alexandria P Cogdill, Boris Engels, Reshma Singh, Tucker R Ezell, Neeraja Idamakanti, Gabriela Plesa, John Seykora, Hideho Okada, Carl June, Jennifer Brogdon, Marcela Maus
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Chimeric antigen receptors are synthetic molecules designed to re-direct T cells to specific surface antigens; CAR-modified T cells can mediate long-term durable remissions in B cell malignancies, but expanding this platform to solid tumors requires the discovery of novel surface
Iatrogenic radiation, and unethical health reforms
Authors: F. Godlee
Journal: BMJ (2011)

Do you know the radiation dose from a computed tomography scan or barium enema? And do you tell your patients? H E Davies and colleagues (doi:10.1136/bmj.d947) provide a useful table of the doses from common radiological investigations. A CT scan of the abdomen delivers 400 times the dose of a chest radiograph. So does a barium enema. Given the high absolute risk of cancer (a one in three lifetime risk), the contribution from iatrogenic radiation is small: the authors estimate that in the UK it causes 800 cancers a year in men and 1300 in women. But for patients who need repeated radiological investigation, …
Health-related quality of life as a predictor of mortality and hospitalization: The Dialysis Outcomes and Practice Patterns Study (DOPPS)
Authors: Donna L. Mapes, Antonio Alberto Lopes, Sudtida Satayathum, Keith P. Mccullough, David A. Goodkin, Francesco Locatelli, Shunichi Fukuhara, Eric W. Young, Kiyoshi Kurokawa, Akira Saito, Jürgen Bommer, Robert A. Wolfe, Philip J. Held, Friedrich K. Port
Journal: Kidney International (2003)
Arsenic: A Roadblock to Potential Animal Waste Management Solutions
Authors: Keeve E. Nachman, Jay P. Graham, Lance B. Price, Ellen K. Silbergeld
Journal: Environmental Health Perspectives (2005)

The localization and intensification of the poultry industry over the past 50 years have incidentally created a largely ignored environmental management crisis. As a result of these changes in poultry production, concentrated animal feeding operations (CAFOs) produce far more waste than can be managed by land disposal within the regions where it is produced. As a result, alternative waste management practices are currently being implemented, including incineration and pelletization of waste. However, organic arsenicals used in poultry feed are converted to inorganic arsenicals in poultry waste, limiting the feasibility of waste management alternatives. The presence of inorganic arsenic in incinerator ash and pelletized waste sold as fertilizer creates opportunities for population exposures that did not previously exist. The removal of arsenic from animal feed is a critical step toward safe poultry waste management.
T cell activation altersintestinal structure and function
Authors: Michael Field
Journal: Journal of Clinical Investigation (2006)

Treatment with anti-CD3 antibody (anti-CD3) causes transient diarrhea. In this issue of the JCI, Clayburgh et al. show that, in jejunum of mice injected with anti-CD3 or with TNF, fluid accumulation and changes in epithelial phenotype develop, the latter including an increase in the passive permeability to proteins, smaller solutes, and water and the endocytosis of the brush border Na+/H+ exchanger, thereby inhibiting Na+ absorption (a second cytokine, LIGHT, has the former effect, but not the latter) (see the related article beginning on page 2682). These phenotypic changes, by themselves, do not, however, explain increased fluid secretion. Since active anion secretion is not stimulated (in fact it is inhibited), a non-epithelial cell-mediated driving force must be present--most likely an increase in interstitial pressure due to an effect of TNF on capillary permeability, smooth muscle contractility, or both.
GRADUATE EDUCATION IN ALLERGY
Authors: Horace S. Baldwin, W. C. Spain
Journal: Annals of Internal Medicine (1949)

Editorial1 June 1949GRADUATE EDUCATION IN ALLERGYHORACE S. BALDWIN, M.D., W. C. SPAIN, M.D., F.A.C.P.HORACE S. BALDWIN, M.D., W. C. SPAIN, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-6-1301 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a recent survey of hospital and medical college residencies and fellowships in allergy conducted by the Subcommittee on Graduate Education of the American Academy of Allergy it was found that 17 institutions in the United States offer facilities for this type of training. Of this group eight stated that it was difficult to attract high grade men. A consideration of this problem furnishes the basis of this report.There would seem to be several reasons for this situation. Ignorance of the opportunities available for research and clinical training in allergy is one. Failure of the present facilities to attract...1 SWINEFORD O: Undergraduate education in allergy, Jr. Assoc. Am. Med. Coll., 1946, xxi, 265-270. Google Scholar2 BARR DP: The relationships of allergy to medicine, Jr. Allergy, 1945, xvi, 61. CrossrefGoogle Scholar3 , Report of the Commission on Graduate Education, 1940, Univ. of Chicago Press, page 14. Google Scholar4 COOKE RA: Allergy in relation to medical education, Clinics, 1946, v, 322. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HORACE S. BALDWIN, M.D.; W. C. SPAIN, M.D., F.A.C.P. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1949Volume 30, Issue 6Page: 1301-1304KeywordsAllergy and immunologyFellowshipsGraduate medical educationHospitalsResidency ePublished: 1 December 2008 Issue Published: 1 June 1949 PDF downloadLoading ...
Vector code differences and similarities
Authors: E. N. Sokolov
Journal: Behavioral and Brain Sciences (1998)

Edelman suggests that any shape is encoded by an excitation vector with components corresponding to excitations of corresponding neuronal modules. This results in discrimination of stimuli in a shape space of low dimensionality. Similar vector encoding is present in color vision. Red-green, blue-yellow, bright and dark neurons are modules that represent a number of different color stimuli in color space of low dimensionality. Vector encoding allows effective computation of color differences and color similarities. Such a neuronal vector-encoding approach has also been applied to the perception of visual movement, line orientation, and stereopsis.
Diagnosis of Empty Sella Syndrome
Authors: Robert W. Jahnke
Journal: JAMA (1982)

To the Editor.—   article The Primary Empty Sella Syndrome: Diagnosis With Metrizamide Cisternography by Young et al carries the strong implication that the technique described, metrizamide-enhanced computed tomography (CT), should be performed using a cervical spinal puncture to introduce the metrizamide. This is not necessary, as a lumbar puncture is sufficient, safer, and more convenient to perform.  excellent density discrimination of CT means that it is not necessary to deliver a highly concentrated bolus to the region being examined. Two of the references that the authors quote advocate the lumbar intrathecal injection of the contrast medium. 1,2 Approximately 4 to 6 mL of 170 to 190 mg of iodine per milliliter is the customary dose when the lumbar route of administration is used, and this is the recommended dose in the package insert supplied by the manufacturer. Higher doses of metrizamide may be necessary if plain-film polytomography is
Correlation between the disease-severity of atopic dermatitis (AD) and the serum levels of interleukin-4 (IL-4) and soluble interleukin-2 receptor (SIL-2R) among egyptian children
Authors: Farag Ibrahim Farag, Waheed Fawzy Hessam, Atef Mohammed Al-Akhras
Journal: Journal of Allergy and Clinical Immunology (2002)
Agonist-Selected T Cell Development Requires Strong T Cell Receptor Signaling and Store-Operated Calcium Entry
Authors: Masatsugu Oh-hora, Noriko Komatsu, Mojgan Pishyareh, Stefan Feske, Shohei Hori, Masaru Taniguchi, Anjana Rao, Hiroshi Takayanagi
Journal: Immunity (2013)
Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects
Authors: MyPhuong T. Le, Reginald F. Frye, Christopher J. Rivard, Jing Cheng, Kim K. McFann, Mark S. Segal, Richard J. Johnson, Julie A. Johnson
Journal: Metabolism (2011)
Abstract 2129: Pediatric diffuse intrinsic pontine gliomas are genetically distinct from high and low grade astrocytomas
Authors: Buczkowicz Pawel, Ute Bartels, Andrew Morrison, Maryam Zarghooni, Eric Bouffet, Cynthia Hawkins
Journal: Cancer Research (2010)

Abstract Tumors of the central nervous system constitute the most common type of solid pediatric tumors and account for the majority of mortality and morbidity in pediatric oncology. Brainstem glioma (BSG) is a type of brain tumor that arises in the medulla, pons or midbrain and accounts for approximately 10-20% of pediatric brain tumors. Diffuse gliomas of the pontine region, diffuse intrinsic pontine glioma (DIPG) are the most common type of brainstem tumor, accounting for about 58-78% of BSG and the number one cause of brain tumor related death in children with a 1-2 year survival. Despite this very little is understood about the biology of these tumors. To try to address this lack of knowledge we have undertaken genomic analysis of a series of DIPGs and compared their copy number changes to those seen in pediatric supratentorial high grade astrocytomas as well as low grade astrocytomas. Post mortem tumor and matched normal brain samples (n= 9) and surgical samples (n= 4) were collected for a series of DIPG patients. We performed high-resolution genetic analysis using whole-genome single-nucleotide polymorphism (SNP) arrays (Affymetrix 500K and 6.0). Data analysis was conducted using Partek Genome Suite and Copy Number Analysis Tool (Affymetrix). Analysis of copy number alterations returned hits in several cancer related pathways including MAPK, Wnt, prostate cancer and gliomagenesis. DIPG copy number was also compared to that of pediatric high grade (n= 20) and low grade (n= 30) astrocytomas. Unsupervised Pearson's Dissimilarity clustering resulted in 3 distinct groups. One contained 6 DIPGs; the second contained mostly LGA with a few HGA, while the third group contained mostly HGA with the remaining DIPGs clustering with this group. Although there were some similarities, DIPG are genetically distinct from supratentorial high grade and low grade astrocytomas. A better understanding of DIPG biology is needed in order to develop agents targeted more specifically towards this disease particularly given the dismal prognosis and unresponsive nature of these tumors to conventional treatment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2129.
Exosomal Fetuin-A identified by proteomics: A novel urinary biomarker for detecting acute kidney injury
Authors: H. Zhou, T. Pisitkun, A. Aponte, P.S.T. Yuen, J.D. Hoffert, H. Yasuda, X. Hu, L. Chawla, R.-F. Shen, M.A. Knepper, R.A. Star
Journal: Kidney International (2006)
Elevated Serum Concentration of Adipose-Derived Factor, Adiponectin, in Patients With Type 1 Diabetes
Authors: Akihisa Imagawa, Tohru Funahashi, Tadashi Nakamura, Makoto Moriwaki, Sachiyo Tanaka, Hitoshi Nishizawa, Kouichi Sayama, Sae Uno, Hiromi Iwahashi, Kazuya Yamagata, Jun-ichiro Miyagawa, Yuji Matsuzawa
Journal: Diabetes Care (2002)

Adiponectin, also referred to as Acrp30, AdipoQ, and GBP28, is a plasma protein exclusively produced by adipose tissue and a possible insulin-sensitizing agent (1–6). Serum adiponectin levels are negatively correlated to BMI in healthy individuals and decreased in type 2 diabetic patients (1–6). However, serum adiponectin levels in type 1 diabetes have not been elucidated.

We examined the serum adiponectin concentrations in 46 type 1 diabetic patients (21 males and 25 females) and compared them with those of BMI-matched healthy control subjects (17 males and 19 females). Mean age was 33 ± 3 and 33 ± 4 years, BMI was 19.8 ± 0.5 and 19.9 ± 0.6 kg/m2, HbA1c level was 9.7± 0.7 and 10.4 ± 0.6%, duration of diabetes was 3.2 ± 0.9 and 3.4 ± 1.3 years, and urinary C-peptide excretion was 18.4 ± 4.3 and 18.0 ± 2.4 μg/day in male and …
Successful allogeneic stem-cell transplantation with prophylactic stepwise G-CSF primed-DLIs for relapse after autologous transplantation in mantle cell lymphoma: A case report and literature review on the evidence of GVL effects in MCL
Authors: S.K. Sohn, J.H. Baek, D.H. Kim, J.T. Jung, D.S. Kwak, S.H. Park, J.S. Suh, K.B. Lee
Journal: American Journal of Hematology (2000)

Mantle cell lymphoma (MCL) is a distinctive clinicopathologic entity and represents 2-8% of all non-Hodgkin's lymphomas. The median survival of patients with MCL is only 3 years, and none of the available conventional chemotherapy regimens appears curative. Encouraging results have been reported with high-dose chemotherapy with autologous stem-cell transplantation (autoSCT). However, a plateau in disease-free survival was not observed in relapsed MCL on the autoSCT trials. Promisingly, alloSCT appears to induce durable remissions via a graft-versus-lymphoma (GVL) effect. Donor lymphocyte infusions (DLIs), by virtue of a GVL effect, have been shown to induce durable remissions in a few cases with refractory MCL that recur after alloSCT. In this article, we review the literature on the evidence of the GVL effects in MCL and describe a patient with relapsed MCL shortly after high-dose chemotherapy with autoSCT. The patient was then successfully treated with Bu/Cy/VP-16 for an alloSCT followed by DLIs in a stepwise fashion. MNCs > 10 x 10(8)/kg were collected by two large-volume leukaphereses from the donor. Harvested stem cells from the 2(nd) day were cryopreserved for the future use as prophylactic DLIs to be given in a stepwise fashion. Cyclosporin and methotrexate were used for GVHD prophylaxis. He had achieved only a partial response by D+64 post transplant. G-CSF-primed cryopreserved DLIs were then infused on D+64 and D+92 to enhance the GVL effect. Grade 3 intestinal GVHD developed 20 days after the 2(nd) DLI and was partially controlled with the combination of cyclosporin, prednisone, and mycophenolate mofetil. Clinical complete remission was observed at D+112, and maintained until the last follow-up day (D+615). Our findings suggest that alloSCT followed by prophylactic DLIs may offer a curative approach to refractory MCL.
I Wish I Could Remember His Name
Authors: Andrew Zweifler
Journal: Annals of Internal Medicine (2009)

Ad Libitum3 November 2009I Wish I Could Remember His NameAndrew Zweifler, MDAndrew Zweifler, MDFrom Ann Arbor, MI 48104.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-9-200911030-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “Thanks for visiting me when I was in the hospital,” he said as he was leaving my office after a 15-minute revisit for treatment of his mild hypertension. I had just written renewals for his prescriptions and was uncertain about when I should schedule his next appointment. His blood pressure control was good, but I was pretty sure his newly diagnosed inoperable pancreatic cancer would preempt follow-up of his blood pressure problem. “I'l see you in six months,” I said, and that's when he looked me in the eye and thanked me. We shook ... Author, Article, and Disclosure InformationAffiliations: From Ann Arbor, MI 48104.Current Author Address: Andrew Zweifler, MD, 1706 South University, Ann Arbor, MI 48104. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 November 2009Volume 151, Issue 9Page: 667KeywordsBlood pressureHospitalizationsHospitalsHypertensionPancreatic cancer ePublished: 3 November 2009 Issue Published: 3 November 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...