AIDS Vaccines: Progress and Unmet Challenges
Authors: Dani P. Bolognesi
Journal: Annals of Internal Medicine (1991)

Editorials15 January 1991AIDS Vaccines: Progress and Unmet ChallengesDani P. Bolognesi, PhDDani P. Bolognesi, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-2-161 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHistorically, vaccines have proved to be the most effective, most economical, and safest means of controlling infectious diseases in animals and humans. Indeed, among the most resounding triumphs in medicine has been the development of successful vaccines against viruses, notably those against smallpox and polio. To date, the biomedical community has had no greater challenge than to develop a vaccine against the human immunodeficiency virus (HIV), a virus that presents unprecedented obstacles to researchers and vaccinologists alike. Although the development of a vaccine for the acquired immunodeficiency syndrome (AIDS) has appeared to be a remote prospect, recent progress along several...References1. LaRosaDavideWeinhold GJK. Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant. Science. 1990;249:932-5. CrossrefMedlineGoogle Scholar2. Gardner M. Vaccination against SIV infection and disease. AIDS Res Hum Retroviruses. 1990;6:835-46. CrossrefMedlineGoogle Scholar3. EminiNaraSchleif EPW. Antibody-mediated in vitro neutralization of human immunodeficiency virus type 1 abolishes infectivity for chimpanzees. J Virol. 1990;64:3674-8. CrossrefMedlineGoogle Scholar4. BermanGregoryRiddle PTL. Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160. Nature. 1990;345:622-5. CrossrefMedlineGoogle Scholar5. GirardFultzKieny MPM. In: Girard M, Valette L, eds. Retroviruses of Human A.I.D.S. and Related Animal Diseases. Quatrieme Colloque des Cent Gardes, Paris, France, 26-28 October, 1989. Paris: Pasteur Vaccins; 1989. Google Scholar6. GardnerStott ME. Progress in SIV vaccine research. Current Science. 1991[In press]. Google Scholar7. SutjiptoPedersenMiller SNC. Inactivated simian immunodeficiency virus vaccine failed to protect rhesus macaques from intravenous or genital mucosal infection but delayed disease in intravenously exposed animals. J Virol. 1990;64:2290-7. CrossrefMedlineGoogle Scholar8. DolinGrahamGreenberg RBS. The safety and immunogenicity of a human immunodeficiency virus type 1 (HIV-1) recombinant gp160 candidate vaccine in humans. Ann Intern Med. 1991;114:119-27. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Dani P. Bolognesi, PhDAffiliations: Duke University Medical Center Durham, NC 27710 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMilestones and Events in the Early Development of Human Gene TherapyA brief history of gene therapyHIV and AIDSHIV infection and surgeons 15 January 1991Volume 114, Issue 2Page: 161-162KeywordsAIDSHIVHIV vaccinesInfectious diseasesPoliomyelitisVaccine developmentVaccines ePublished: 1 December 2008 Issue Published: 15 January 1991 PDF downloadLoading ...