tbuckley/cabot-search huggingface dataset:
A heterozygous frameshift mutation in PRKRA (DYT16) associated with generalised dystonia in a German patient
Authors: Philip Seibler, Ana Djarmati, Brigitte Langpap, Johann Hagenah, Alexander Schmidt, Norbert Brüggemann, Hartwig Siebner, Hans-Christian Jabusch, Eckart Altenmüller, Alexander Münchau, Katja Lohmann, Christine Klein
Journal: The Lancet Neurology (2008)
THE IMPORTANCE OF THE STATE GOVERNMENT CONTROL OF ARTIFICIAL AGENCIES THAT MAY BE PRODUCTIVE OF NOISES.
Authors: AUGUSTUS P. CLARKE
Journal: JAMA (1895)

The inhabitants of the American States have long been noted for their hurrying and bustling habits, for their ceaseless, restless activities, and for their all but immodest disposition when setting themselves about to accomplish a purpose, not to intrust the fact to the keeping of a silent herald. So marked have these characteristics become and so influential have they been in modifying the development of their personality that Europeans, surrounded by other amenities and pleasures, have fancied that the average American citizen is still but a son of the forest, that the noises incident to his movements are only the rustling of his feathery head-gear, that the implements of his trade are the disguises of the tomahawk, and that the acclamations expressed upon the success he attains are not unlike the war-whoop of his aboriginal predecessors. After eliminating from our field of vision all the extravagances of imagination indulged in
Long-term outcomes in patients with severe sepsis randomised to resuscitation with hydroxyethyl starch 130/0.42 or Ringer’s acetate
Authors: Anders Perner, Nicolai Haase, Per Winkel, Anne B. Guttormsen, Jyrki Tenhunen, Gudmundur Klemenzson, Rasmus G. Müller, Anders Åneman, Jørn Wetterslev
Journal: Intensive Care Medicine (2014)
The Problem of Furred Pets in Childhood Atopic Disease Failure of an Information Program
Authors: Bengt Kjellman, Rolf Pettersson
Journal: Allergy (1983)

This epidemiological study is based on all schoolchildren ( n = 40,010)) in a Swedish county (population: 270,000) and analyses by questionnaire, 1) the prevalence of regular direct contact with furred animals, 2) the prevalence of allergy to animal danders, 3) the prevalence among child asthmatics of regular direct contacts with furred animals correlated to the efforts made to impart information on allergy. 4) A comparison between levels of medical care/medicine‐intake in dander‐allergic and non‐dander‐allergic child asthmatics. This method gave the following results: 1) 52% of schoolchildren have furred pets in their homes (urban area: 39%, rural area: 77%), and 24% ride and/or have contact with animals in barns and stables, 2) The overall prevalence of dander allergy was 5.3%, in child asthmatics 57%; and in children with allergic rhinitis 30%, 3) Non‐dander‐allergic child asthmatics have more regular direct contact with furred animals than non‐asthmatics. The incidence of domestic pet‐keeping by dander‐allergic child‐asthmatics is less than half that of non‐asthmatics, 4) Dander‐allergic child‐asthmatics have a higher level of medical care/medicine‐intake, than the non‐allergic. It is stressed that the family with an atopic child should be informed as soon as possible of the furred animal problem, i.e. before they have bought such a pet.
Giant, Nonfunctioning Carcinoma of the Adrenal Cortex
Authors: Antonio Fimmanò, Guido Pettinato, Claudio Bonuso, Claudia Cirillo, Rosanna Di Carlo
Journal: New England Journal of Medicine (2001)

Tuomilehto et al. (May 3 issue) 1 reported that counseling subjects at high risk for type 2 diabetes mellitus to reduce weight and the intake of fat and to increase physical exercise and the intake of fiber reduced the risk of diabetes by 58 percent, as compared with the risk in a usualcare group.We would like to know whether the weight loss in the intervention group was maintained throughout the follow-up period (i.e., at six years of follow-up).Most subjects in weight-loss programs have been unable to sustain weight loss, and in several studies more than 90 percent of subjects who lost weight eventually returned to their original weight. 2,3e also wonder what kind of antihypertensive drugs were prescribed in the intervention and control groups.In particular, we would like to know how many of the patients in the two groups received an angiotensin-converting-enzyme (ACE) inhibitor, which according to the Heart Outcomes Prevention Evaluation (HOPE) trial is associated with a decrease in the incidence of diabetes mellitus.
Characterisation of an OCS-dependent severe asthma population treated with mepolizumab
Authors: C M Prazma, S Wenzel, N Barnes, J A Douglass, B F Hartley, H Ortega
Journal: Thorax (2014)

A subpopulation of patients with asthma treated with maximal inhaled treatments is unable to maintain asthma control and requires additional therapy with oral corticosteroids (OCS); a subset of this population continues to have frequent exacerbations. Alternate treatment options are needed as daily use of OCS is associated with significant systemic adverse effects that affect many body systems and have a direct association with the dose and duration of OCS use. We compared the population demographics, medical conditions and efficacy responses of the OCS-dependent group from the DREAM study of mepolizumab with the group not managed with daily OCS. <h3>Trial Registration Number</h3> NCT01000506.
Plasma Concentrations of Digoxin after Oral Administration in the Fasting and Postprandial State
Authors: R. J. White, D. A. Chamberlain, M. Howard, T. W. Smith
Journal: BMJ (1971)

After the oral administration of 0·5 mg of digoxin in tablet form to fasting subjects peak plasma levels were reached in 30 to 60 minutes. Levels then fell to reach a plateau at six to eight hours. When the same dose was given after food the peak plasma concentrations were significantly lower, but the concentrations reached in samples obtained from two to eight hours after the dose did not differ appreciably from corresponding samples obtained in the fasting experiments. In a four-week cross-over study of 21 patients on maintenance therapy, digoxin taken regularly in the fasting state produced plasma concentrations similar to those obtained when the drug was taken after meals. The rapid appearance of digoxin in the blood suggests that the oral route of administration is adequate for most patients who require rapid digitalization, and the timing of maintenance dosage in relation to meals is unimportant.
Effect of station design on death in the London Underground: observational study
Authors: T J Coats, D P Walter
Journal: BMJ (1999)

The balance between individual and societal pathways is likely to vary from one country to another, from one period to another, and with the size of the areas over which inequality is measured.But regardless of the pathway, the relation between income inequality and population health suggests that reducing health inequalities need not conflict with the desire to raise health standards throughout society.Instead of redistributing a given amount of health or health producing goods in a zero sum game, we can be confident that increased wellbeing among the least well off need not be matched by losses among the rich. 1
IN VIVO BIOCOMPATIBILITY COMPARISON BETWEEN NOVEL BIODEGRADABLE POLYMER AND EXISTING NON-BIODEGRADABLE POLYMER COATED STENTS
Authors: Shizu Oyamada, Xiaodong Ma, Tim Wu, Michael P. Robich, Cesario Bianchi, Frank W. Sellke, Roger J. Laham
Journal: Journal of the American College of Cardiology (2010)
Endothelial Dysfunction Is Detectable in Young Normotensive First-Degree Relatives of Subjects With Type 2 Diabetes in Association With Insulin Resistance
Authors: Bernd M. Balletshofer, Kilian Rittig, Markus D. Enderle, Anette Volk, Elke Maerker, Stephan Jacob, Stephan Matthaei, Kristian Rett, Hans U. Häring
Journal: Circulation (2000)

Endothelial dysfunction (ED) is regarded as an early step in the development of atherosclerosis. Among the pathogenetic factors leading to atherosclerosis, the role of insulin resistance and hyperinsulinemia as independent risk factors is still under debate. In this study, we examined the association between ED and insulin resistance in normotensive and normoglycemic first-degree relatives (FDRs) of patients with type 2 diabetes mellitus (DM).Endothelium-dependent and -independent vasodilation of the brachial artery was measured with high-resolution ultrasound (13 MHz) in 53 normotensive FDRs (21 men, 32 women; mean age, 35 years) with normal oral glucose tolerance, 10 age- and sex-matched normal control subjects, and 25 DM patients (mean age, 57 years). According to the tertiles of the clamp-derived glucose metabolic clearance rate (MCR), the FDRs were further classified as insulin resistant with an MCR <or =5.8 mL. kg(-1). min(-1), insulin sensitive (IS) with an MCR > or =7.8 mL. kg(-1). min(-1), and borderline with an MCR of 5.9 to 7.7 mL. kg(-1). min(-1). Flow-associated dilation was 4.1+/-0.9% in insulin-resistant FDRs, 6.7+/-1.1% in borderline FDRs, 9.0+/-1.2% in insulin-sensitive FDRs (P=0.002), 7.7+/-2.9% in control subjects (P=NS versus FDRs), and 3.8+/-1.0% in DM patients (P=0.03). In multiple regression analysis, low MCR was significantly correlated with ED independent of age, sex, smoking, body mass index, percent body fat, serum insulin, and lipids.There is a significant association between ED and insulin resistance in young FDRs of DM subjects independent of the classic cardiovascular risk factors.
Demyelinating Encephalomyelitis in a Case of Tetanus Treated with Antitoxin
Authors: Harold W. Williams, Francis H. Chafee
Journal: New England Journal of Medicine (1961)

THE finding of areas of extensive perivascular demyelinization with a predilection for white matter in the brain of a patient who had had clinical tetanus provoked interest in the possible relation to tetanus antitoxin. For fatal tetanus, whether treated with antitoxin or not, presents no significant structural changes in the pathological anatomy of the central nervous system.1 , 2 Case ReportF.G., a 13-year-old boy who was an avid tree climber, was admitted to the Rhode Island Hospital on 2 occasions as a result of falls. The first was on December 30, 1957, when a laceration of the car was sutured. He . . .
Systems biology of diuretic resistance
Authors: Mark A. Knepper
Journal: Journal of Clinical Investigation (2015)

Diuretics are commonly used to treat hypertension and extracellular fluid volume expansion. However, the development of compensatory responses in the kidney limits the benefit of this class of drugs. In this issue of the JCI, Grimm and colleagues use a systems biology approach in mice lacking the kinase SPAK and unravel a complex mechanism that explains thiazide diuretic resistance. The overall process involves interactions among six different cell types in the kidney.
Risk factors of polysensitization to contact allergens
Authors: J. Schwitulla, O. Gefeller, A. Schnuch, W. Uter
Journal: British Journal of Dermatology (2013)

'Polysensitization' (PS) is usually defined as contact sensitization to three or more unrelated haptens of the baseline patch test series. Despite PS being an important clinical phenotype indicating increased susceptibility to contact allergy, statistical approaches to analyse PS have hitherto been preliminary.To apply an appropriate regression model for count data, namely, negative binomial hurdle regression, to a large set of clinical patch test data with the aim of estimating PS risk in more detail than previously achieved.The detailed information provided by the hurdle model includes a separate estimation of an 'increment factor' quantifying the likelihood of further positive reactions, i.e. PS. Clinical data of 126 878 patients patch tested by departments comprising the IVDK (Information Network of Departments of Dermatology) network (www.ivdk.org) between 1995 and 2010 were included.Regarding anatomical sites as exposure (surrogate), the axillae and the feet were found to be strong PS risk factors. Moreover, age was a strong PS risk factor, and less so, female sex. In comparison, atopic eczema and occupational dermatitis were less important risk factors. Single allergens contributed to PS to a varying extent.The data presented point to some, very likely exposure-related, risk factors which need to be considered in future PS research, e.g. addressing the genetic basis for PS.
Relationship between total and allergen‐specific IgE serum levels and presence of symptoms in farm workers sensitized to <i>Tetranychus urticae</i>
Authors: D. Gargano, C. Romano, F. Manguso, M. Cutajar, P. Altucci, C. Astarita
Journal: Allergy (2002)

Background: Clinical complaints in atopic subjects with asthma and rhinitis occur more frequently in the presence of high total and allergen‐specific IgE serum levels. Here we report on the relationship between total and allergen‐specific IgE serum levels and presence of symptoms in an unselected farmer population sensitized to Tetranychus urticae (TU). Methods: Farmers were recruited as previously described. Total IgE and allergen‐specific IgE were measured by immunoassay in TU‐positive skin prick test (SPT) farmers ( n = 58) and two control groups including Dermatophagoides pteronyssinus (Dp)‐positive SPT subjects ( n = 40) and non‐atopic, TU‐negative SPT healthy farmers ( n = 25) . Results: Both TU+ and Dp+ subjects had significantly higher total IgE values ( P &lt; 0.001) than healthy non‐atopic subjects. TU‐specific IgE levels were significantly more elevated in symptomatic than non‐symptomatic TU+ subjects ( P = 0.028). Dp‐specific IgE levels were higher in symptomatic than non‐symptomatic Dp+ subjects ( P = 0.003). Finally, total IgE levels were significantly higher in the symptomatic than non‐symptomatic subgroups in both TU+ and Dp+ subjects ( P &lt; 0.0001 and P = 0.007, respectively). Logistic regression analysis showed that only total IgE concentrations were significant predictors of current symptoms in TU+ subjects. Conclusions: High total IgE and allergen‐specific IgE levels are associated with symptoms in TU+ subjects. Definition of their predictive value requires further studies.
LOW PREVALENCE IN THE UK OF HTLV-I AND HTLV-II INFECTION IN SUBJECTS WITH AIDS, WITH EXTENDED LYMPHADENOPATHY, AND AT RISK OF AIDS
Authors: R.S. Tedder, D.C. Shanson, D.J. Jeffries, R. Cheingsong-Popov, A. Dalgleish, P. Clapham, K. Nagy, R.A. Weiss
Journal: The Lancet (1984)
Inflammatory Biomarkers, Hormone Replacement Therapy, and Incident Coronary Heart Disease
Authors: Aruna D. Pradhan, JoAnn E. Manson, Jacques E. Rossouw, David S. Siscovick, Charles P. Mouton, Nader Rifai, Robert B. Wallace, Rebecca D. Jackson, Mary B. Pettinger, Paul M Ridker
Journal: JAMA (2002)

ContextPostmenopausal hormone replacement therapy (HRT) has been shown to elevate C-reactive protein (CRP) levels. Several inflammatory biomarkers, including CRP, are associated with increased cardiovascular risk. However, whether the effect of HRT on CRP represents a clinical hazard is unknown.ObjectivesTo assess the association between baseline levels of CRP and interleukin 6 (IL-6) and incident coronary heart disease (CHD) and to examine the relationship between baseline use of HRT, CRP, and IL-6 levels as they relate to subsequent vascular risk.Design, Setting, and ParticipantsProspective, nested case-control study of postmenopausal women, forming part of the Women's Health Initiative, a large, nationwide, observational study. Among 75 343 women with no history of cardiovascular disease or cancer, 304 women who developed incident CHD were defined as cases and matched by age, smoking status, ethnicity, and follow-up time with 304 study participants who remained event free during a median observation period of 2.9 years.Main Outcome MeasureIncidence of first myocardial infarction or death from CHD.ResultsMedian baseline levels of CRP (0.33 vs 0.25 mg/dL; interquartile range [IQR], 0.14-0.71 vs 0.10-0.47; P<.001) and IL-6 (1.81 vs 1.47 pg/mL; IQR, 1.30-2.75 vs 1.05-2.15; P<.001) were significantly higher among cases compared with controls. In matched analyses, the odds ratio (OR) for incident CHD in the highest vs lowest quartile was 2.3 for CRP (95% confidence interval [CI], 1.4-3.7; P for trend = .002) and 3.3 for IL-6 (95% CI, 2.0-5.5; P for trend <.001). After additional adjustment for lipid and nonlipid risk factors, both inflammatory markers were significantly associated with a 2-fold increase in odds for CHD events. As anticipated, current use of HRT was associated with significantly elevated median CRP levels. However, there was no association between HRT and IL-6. In analyses comparing individuals with comparable baseline levels of either CRP or IL-6, those taking or not taking HRT had similar CHD ORs. In analyses stratified by HRT, we observed a positively graded relationship between plasma CRP levels and the OR for CHD among both users and nonusers of HRT across the full spectrum of baseline CRP.ConclusionsThese prospective findings indicate that CRP and IL-6 independently predict vascular events among apparently healthy postmenopausal women and that HRT increases CRP. However, use or nonuse of HRT had less importance as a predictor of cardiovascular risk than did baseline levels of either CRP or IL-6.
Assessment of the pulmonary vascular bed by echocardiographic right ventricular systolic time intervals.
Authors: T Riggs, S Hirschfeld, G Borkat, J Knoke, J Liebman
Journal: Circulation (1978)

Echocardiography was used to measure right ventricular systolic time intervals (RVSTI) in 85 normal children (group I) and in 229 patients undergoing cardiac catheterization (group II). Corrected right ventricular pre-ejection period (RPEPC) and right ventricular ejection time (RVETc) (based on regression analysis of group I) and RPEP/RVET were each correlated with pulmonary artery (PA) diastolic and mean pressures and pulmonary vascular resistance (PVR). The best correlation (0.83) was between a second degree polynomial of the RPEP/RVET and PA diastolic pressure. The RPEP/RVET allowed prediction of PA diastolic pressure within 10 mm Hg in 85% of the patients. The utility of RPEP/RVET was confirmed in sequential data of 22 patients, in whom alteration in RPEP/RVET accurately reflected the changing PA diastolic pressure. The RPEP/RVET could not be used to assess PA pressure in six patients with congestive cardiomyopathy nor in 18 patients with complete right bundle branch block (CRBBB).
Hepatotoxicity profile of single agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia, its impact on clinical outcome and the effect of genetic polymorphisms on the incidence of hepatotoxicity
Authors: V Mathews, S Desire, B George, K M Lakshmi, J G Rao, A Viswabandya, A Bajel, V M Srivastava, A Srivastava, M Chandy
Journal: Leukemia (2006)
The U2 small nuclear ribonucleoprotein particle as an autoantigen. Analysis with sera from patients with overlap syndromes.
Authors: J Craft, T Mimori, T L Olsen, J A Hardin
Journal: Journal of Clinical Investigation (1988)

We identified eight patients whose sera contained autoantibodies to the U2 small nuclear ribonucleoprotein (snRNP), an RNA protein particle involved in the splicing of newly transcribed messenger RNA. Each of these patients had an overlap syndrome that included features of either systemic lupus erythematosus (SLE), scleroderma, and/or polymyositis. We then used these sera to characterize the autoantigenic polypeptides of the U1 and U2 snRNP particles. In immunoblots, all sera contained antibodies to the B" polypeptide of the U2 snRNP. A subset of these sera that more effectively immunoprecipitated the native U2 particle contained an additional antibody system that recognized the A' polypeptide of this snRNP. Antibodies eluted from the B" protein bound the A polypeptide of the U1 snRNP and vice versa. Moreover, antibodies to the B" polypeptide were accompanied by antibodies to the 68K and C polypeptides of the U1 snRNP. Finally, the A' and B" polypeptides remained physically associated after the U2 particle was cleaved with RNase. Thus these sera contain multiple autoantibody systems that, at one level, target two physically associated antigenic polypeptides of the U2 particle and, at another, target two snRNP particles which are associated during the splicing of premessenger RNA. These linked autoantibody sets provide further evidence that intact macromolecular structures are targeted by the immune response in SLE and related diseases.
Tumor-Specific T-cell Help Is Associated with Improved Survival in Melanoma
Authors: Katherine Woods, Jonathan Cebon
Journal: Clinical Cancer Research (2013)

Abstract Despite success with immune checkpoint inhibitors, clinical benefit from cancer vaccines remains elusive. Combined targeting of melanoma-specific CD4+ and CD8+ T-lymphocyte epitopes was associated with improved survival compared with targeting either alone, or when a nonspecific helper epitope was used. We discuss the potential role of antigen-specific CD4 help. Clin Cancer Res; 19(15); 4021–3. ©2013 AACR.
Early postinfarction ventricular restraint prevents adverse remodeling and preserves borderzone contractile function
Authors: Benjamin M. Jackson, Joseph H. Gorman, Sina L. Moainie, Navneet Narula, Jagat Narula, Martin G. St. John Sutton, L.H. Edmunds, Robert C. Gorman
Journal: Journal of the American College of Cardiology (2003)
Commitment of the National Institute of Environmental Health Sciences to community-based participatory research for rural health.
Authors: L R O'Fallon, A Dearry
Journal: Environmental Health Perspectives (2001)

The National Institute of Environmental Health Sciences (NIEHS) is the leading biomedical research institution in the United States whose mission is to support research that seeks to understand how environmental exposures affect human health. NIEHS possesses a longstanding interest in the health effects of agrochemical and other environmental exposures in rural America, including pesticides, to farmers and their families and to migrant farmworkers and their families. In recent years, NIEHS has begun augmenting traditional basic science investigations with innovative programs that translate findings from the laboratory to affected populations. It is through community-based participatory research that NIEHS strives to advance the public health field by fostering the development of culturally relevant interventions that will reduce exposures to environmental contaminants and the risk of environmentally induced disease. In this article, we describe the translational research program at NIEHS as it relates to the NIEHS mission and highlight activities pertinent to the health of rural communities, especially underserved populations. We provide an overview of NIEHS-supported projects addressing health concerns of Native American and rural African-American communities in addition to farmworkers. We conclude with a discussion of future plans for community-based participatory research at NIEHS.
Gfi-1 inhibits proliferation and colony formation of p210BCR/ABL-expressing cells via transcriptional repression of STAT 5 and Mcl-1
Authors: A R Soliera, S A Mariani, A Audia, M R Lidonnici, S Addya, G Ferrari-Amorotti, S Cattelani, G Manzotti, V Fragliasso, L Peterson, G Perini, T L Holyoake, B Calabretta
Journal: Leukemia (2012)
SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice
Authors: Y. Ma, W. Cui, J. Yang, J. Qu, C. Di, H. M. Amin, R. Lai, J. Ritz, D. S. Krause, L. Chai
Journal: Blood (2006)
A memorable patient: Protective pipe smoking
Authors: R. J House
Journal: BMJ (1997)

When I first started in general practice in 1946 a man of about 80 came to see me and, as it was my first contact with him, I asked a few leading questions about his health and his smoking habits. He replied–“I smokes a pipe and it's all the fault of you doctors.” Sensing a story, I asked for an explanation. …