tbuckley/cabot-search huggingface dataset:
SUBACUTE BACTERIAL ENDOCARDITIS COMPLICATED BY PREGNANCY
Authors: J. Lester Kobacker
Journal: JAMA (1930)

There have been frequent reports in the literature of cases of subacute bacterial endocarditis occurring during the puerperium, yet there have been few bona fide cases of the disease observed during pregnancy. Walser 1 recently published a fairly exhaustive review of the literature and was able to find only two unquestioned examples of endocarditis lenta associated with pregnancy, to which he added two cases. He found that true malignant or ulcerative endocarditis had been reported not infrequently, beginning with the case of Litten's 2 in 1878. The textbooks make no mention of the condition in pregnancy, and in extensive series of cases, such as those reported by Libman 3 and Blumer, 4 there is no reference to any case complicated by pregnancy. Libman 5 infers in one article that cases of bacterial endocarditis of the puerperium may be the result of an old infection present before delivery and not of
The Utility of CPR in Elderly Persons-Reply
Authors: W. T. Longstreth
Journal: JAMA (1991)

In Reply.—  Dr Weston's concern is appropriate. In the review by Greene, 1 the derived 75% proportion is inflated due to his misinterpretation of a previous report. 2 The 37% incidence in our study is similar to that in previous reports from Seattle (39% and 42%) 3,4 and is comparable to the experience that Dr Weston describes. 5 The 63% proportion reported by Eisenberg and associates 6 from suburban King County described findings in selected patients. More recent data from that emergency medical services system indicate that ventricular fibrillation was present in 37.6% of several thousand consecutive arrests, excluding trauma-related events (Mickey S. Eisenberg, MD, PhD, Richard O. Cummins, MD, and Mary Pat Larsen, MA, written communication, December 1990). Hence, 35% to 40% is a reasonable approximation of the proportion of out-of-hospital arrest victims who have ventricular fibrillation as the first recorded rhythm.  The figure will differ depending on the
Circadian Regulation of mTOR by the Ubiquitin Pathway in Renal Cell Carcinoma
Authors: Hiroyuki Okazaki, Naoya Matsunaga, Takashi Fujioka, Fumiyasu Okazaki, Yui Akagawa, Yuuya Tsurudome, Mayumi Ono, Michihiko Kuwano, Satoru Koyanagi, Shigehiro Ohdo
Journal: Cancer Research (2013)

Circadian clock systems regulate many biologic functions, including cell division and hormone secretion in mammals. In this study, we explored the effects of circadian control on the pivot cell growth regulatory mTOR, the activity of which is deregulated in tumor cells compared with normal cells. Specifically, we investigated whether the antitumor effect of an mTOR inhibitor could be improved by changing its dosing schedule in RenCa tumor-bearing mice. Active, phosphorylated mTOR displayed a 24-hour rhythm, and levels of total mTOR protein (but not mRNA) also showed a circadian rhythm in RenCa tumor masses. Through investigations of the oscillation mechanism for mTOR expression, we identified the ubiquitination factor Fbxw7 as an mTOR regulator that oscillated in its expression in a manner opposite from mTOR. Fbxw7 transcription was regulated by the circadian regulator D-site-binding protein. Notably, administration of the mTOR inhibitor everolimus during periods of elevated mTOR improved survival in tumor-bearing mice. Our findings demonstrate that the circadian oscillation of mTOR activity is regulated by circadian clock systems, which influence the antitumor effect of mTOR inhibitors.
Surgery for Evolving Myocardial Infarction
Authors: Steven J. Phillips
Journal: JAMA (1982)

One hundred fifty-six patients underwent emergency coronary revascularization during the early phases of evolving myocardial infarction (MI). There were six hospital deaths (3.8%) and two later deaths (1.3%). Thrombectomy of the MI artery was achieved in 79% of the patients, and 17% of the patients showed no observable lesion in the MI vessel on restudy. Graft patency was 99%. Late follow-up to 62 months disclosed 17 patients with residual limitations. Analysis of the data established criteria for recognizing patients with early MI who would benefit from surgical therapy. The criteria are derived by comparing preoperative and postoperative ventricular anatomy, creatine phosphokinase levels, and hemodynamics. (<i>JAMA</i>1982;248:1325-1328)
Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial
Authors: Carl D. Langefeld, Jasmin Divers, Nicholas M. Pajewski, Amret T. Hawfield, David M. Reboussin, Diane E. Bild, George A. Kaysen, Paul L. Kimmel, Dominic S. Raj, Ana C. Ricardo, Jackson T. Wright, John R. Sedor, Michael V. Rocco, Barry I. Freedman
Journal: Kidney International (2014)
Charles Peter William Warren
Authors: D. K. C. Cooper
Journal: BMJ (2011)

I am sad to report the unexpected and sudden death of Peter Warren in Winnipeg, Manitoba, on 3 May 2011. Peter Warren was a Guy’s graduate who became an authority on pulmonary disease and reached the highest echelons of the medical professions in Canada.

Peter Warren—the son of Wilfrid Warren, a distinguished psychiatrist—was born on 4 October 1940 in Plymouth, Devon, and educated at Sherborne School. He came to study clinical medicine at Guy’s Hospital in 1961, having taken a BA at Sidney Sussex College, Cambridge. In his three years as a clinical student at Guy’s he excelled academically, winning the Hillman prize for haematology, the Larkin prize for medicine, the Oldham prize for ophthalmology, and the treasurer’s gold medals for both medicine and surgery—an absolutely stellar achievement. Remarkably, he also found time to represent the Hospital Boat Club in the first VIII, where he proved a dedicated and reliable oarsman. He graduated in medicine in 1964.

Between 1964 and 1966 he held house appointments at Guy’s. He followed this with a house officer appointment in cardiology at the Brompton Hospital, after which he was appointed junior lecturer in the department of medicine at Guy’s, obtaining the MRCP in 1967 (becoming FRCP in 1987). There followed a registrarship in general medicine and chest diseases at St George’s …
Prevalence of silent kidney disease in Hong Kong: The Screening for Hong Kong Asymptomatic Renal Population and Evaluation (SHARE) program
Authors: Philip Kam-Tao Li, Bonnie Ching-Ha Kwan, Chi Bon Leung, Tze Hoi Kwan, Kim Ming Wong, Sing Leung Lui, Waikay Tsang, Christopher Chun Yu Mak, Siuka Mak, Alexwai-Yin Yu, Sydney Tang
Journal: Kidney International (2005)
INTRACELLULAR HYDROGEN ION CONCENTRATION
Authors: Edward J. Stieglitz
Journal: JAMA (1927)

<h3>To the Editor:</h3> —In an editorial (The Journal, July 2) in which the work of Chambers and his co-workers (Chambers, R., and Pollack, H.:<i>J. Gen. Physiol</i>.<b>10</b>:739, 1927) was discussed and most deservedly praised, it was emphasized that the intracellular hydrogen ion concentration of living cells is remarkably unchanging and uniform except when the cells are injured. Such emphasis may be misleading to those uninformed of previous work in this field of investigation, for it has been clearly demonstrated that such fixity of reaction is<i>not</i>the case, particularly in functionally active secreting cells. In 1924, observations were published (Stieglitz, E. J.:<i>Arch. Int. Med</i>.<b>33</b>:483 [April] 1924) clearly describing wide variations in intracellular hydrogen ion concentrations in the secreting renal parenchyma, and it was shown that these variations have distinct physiologic associations. Long previous to this work, Harvey and Bensley (<i>Biol. Bull</i>.<b>23</b>:255, 1912) and
LONGITUDINAL OBSERVATIONS OF BIOLOGICAL DEVIATIONS IN A SCHIZOPHRENIC INFANT
Authors: BARBARA FISH
Journal: American Journal of Psychiatry (1959)

The longitudinal observations made on this child, who is clinically schizophrenic at 5½ years, show that the normal progress of neurological and physiological maturation [refer Source PDF] was disrupted as early as 1 month of age. Biological development differed significantly from the other infants studied by the author, from norms of growth and development previously established on hundreds of children by Gesell and others, and from the usual forms of retarded or precocious development. The following deviations were discussed: 1. The presence of an abnormal torpid state in the first months of life, 2. A severe but transient lag and disorganization in postural-locomotor development, and 3. Physiological disturbances which paralleled the transient neurological disturbances, including retarded physical growth and autonomic instability. These biological manifestations antedated the anxiety and psychological symptoms, and appeared to be intimately related to the later clinical manifestations of schizophrenia. A preliminary study such as this raises more questions than it answers. We plan to study a much larger number of infants to determine the critical limits beyond which erratic development may be the first sign of schizophrenia, as distinguished from the spectrum of relatively benign individual variations; and to study how different patterns of maternal care and early physiological support can modify this development. The capacity of different individuals to maintain psychological integrity in the face of stress is often attributed to elusive qualities we summarize as ego strength. It would appear that there is a related variation in the capacity for integration in the early neurophysiological development of infants. Differences in the growing organization of alertness and muscle tonus, the progression of postural control, physical growth and autonomic stability lend themselves to quantitative measurement and analysis. We believe that further study of these individual differences in early neurological integration should increase our understanding of the factors making for mental health and disease.
Combination Immunotherapy after ASCT for Multiple Myeloma Using MAGE-A3/Poly-ICLC Immunizations Followed by Adoptive Transfer of Vaccine-Primed and Costimulated Autologous T Cells
Authors: Aaron P. Rapoport, Nicole A. Aqui, Edward A. Stadtmauer, Dan T. Vogl, Yin Yan Xu, Michael Kalos, Ling Cai, Hong-Bin Fang, Brendan M. Weiss, Ashraf Badros, Saul Yanovich, Gorgun Akpek, Patricia Tsao, Alan Cross, Dean Mann, Sunita Philip, Naseem Kerr, Andrea Brennan, Zhaohui Zheng, Kathleen Ruehle, Todd Milliron, Scott E. Strome, Andres M. Salazar, Bruce L. Levine, Carl H. June
Journal: Clinical Cancer Research (2014)

Myeloma-directed cellular immune responses after autologous stem cell transplantation (ASCT) may reduce relapse rates. We studied whether coinjecting the TLR-3 agonist and vaccine adjuvant Poly-ICLC with a MAGE-A3 peptide vaccine was safe and would elicit a high frequency of vaccine-directed immune responses when combined with vaccine-primed and costimulated autologous T cells.In a phase II clinical trial (NCT01245673), we evaluated the safety and activity of ex vivo expanded autologous T cells primed in vivo using a MAGE-A3 multipeptide vaccine (compound GL-0817) combined with Poly-ICLC (Hiltonol), granulocyte macrophage colony-stimulating factor (GM-CSF) ± montanide. Twenty-seven patients with active and/or high-risk myeloma received autografts followed by anti-CD3/anti-CD28-costimulated autologous T cells, accompanied by MAGE-A3 peptide immunizations before T-cell collection and five times after ASCT. Immune responses to the vaccine were evaluated by cytokine production (all patients), dextramer binding to CD8(+) T cells, and ELISA performed serially after transplant.T-cell infusions were well tolerated, whereas vaccine injection site reactions occurred in >90% of patients. Two of nine patients who received montanide developed sterile abscesses; however, this did not occur in the 18 patients who did not receive montanide. Dextramer staining demonstrated MAGE-A3-specific CD8 T cells in 7 of 8 evaluable HLA-A2(+) patients (88%), whereas vaccine-specific cytokine-producing T cells were generated in 19 of 25 patients (76%). Antibody responses developed in 7 of 9 patients (78%) who received montanide and only weakly in 2 of 18 patients (11%) who did not. The 2-year overall survival was 74% [95% confidence interval (CI), 54%-100%] and 2-year event-free survival was 56% (95% CI, 37%-85%).A high frequency of vaccine-specific T-cell responses were generated after transplant by combining costimulated autologous T cells with a Poly-ICLC/GM-CSF-primed MAGE-A3 vaccine.
ORTHOPEDIC PREVENTIVE MEDICINE
Authors: HENRY BASCOM THOMAS
Journal: JAMA (1924)

Preventive medicine carries a wide social implication, since, by maintaining a high ratio of sound and efficient individuals, it reduces proportionately the burdens and problems imposed on the state and society by the physically handicapped. Orthopedic surgery can claim a modest share in the development and application of methods of preventing disease, although our specialty is generally considered as only loosely associated with those that are recognized as having made the most important advances in preventive medicine. By devoting this paper to the prevention of deformities, I hope to bring to the attention of the medical profession a realization of the effective work now being done, and of the possibilities of wider cooperation within the medical profession and with the various social agencies concerned with children and with industrial conditions. I have selected five types of cases frequently recurring in orthopedic practice through which to demonstrate the possibility of the
Cell cycle arrest and apoptosis induction in hepatocellular carcinoma cells by HMG-CoA reductase inhibitors. Synergistic antiproliferative action with ligands of the peripheral benzodiazepine receptor
Authors: Andreas P. Sutter, Kerstin Maaser, Michael Höpfner, Alexander Huether, Detlef Schuppan, Hans Scherübl
Journal: Journal of Hepatology (2005)
Allergological Examination of Cystic Fibrosis Patients with Skin Reactions During Carbenicillin Treatment
Authors: N. E. Møller, S. Ahlstedt, P. Stahl Skov, S. Norn
Journal: Allergy (1980)

Sixteen of 84 cystic fibrosis patients developed skin manifestations during intensive carbenicillin therapy. The possibility of allergic drug reactions was examined. None of the patients showed any significant levels of antibodies of IgE, IgG or IgM classes against carbenicillin and different penicialloyl determinants as recorded with RAST. Sandwitch‐radioimmunoassay and double antibody assay. The leukocytes of the patients did not release histamine on in vitro provocation with carbenicillin. Furthermore, none of the patients responded to prick test or to peroral penicillin provocation. The negative findings indicated that the recorded reactions were most probably not due to antibody mediated allergy of type I or type III.
Models for association in bivariate survival data.
Authors: Y Fujii
Journal: Environmental Health Perspectives (1990)

This paper reviews dependence models for bivariate survival data, classifying them into the four groups: the shock model, the Freund model, the Clayton model, and the mixture model. The paper then concentrates on the mixture model, discussing the testing problem for the equality of marginal distributions under the Weibull type baseline hazard assumption. The new test proposed recently by Fujii is introduced, and its characteristic is studied with respect to the test proposed by Nayak and the sign test by simulation study.
Dietary treatment of Crohn's disease
Authors: R. Allan
Journal: Gut (1986)

Crohn's disease in married couples SIR,-We were interested to read of Crohn's disease occurring in two married couples (Gut 1985; 26: 1086) and would like to draw attention to a further example:Mr DH, born 1931, caucasian, presented in late 1960 with abdominal pain.A laparotomy was done and revealed Crohn's disease of the terminal ileum.In February 1966 a right hemicolectomy was carried out for a stricture of the terminal ileum and an abscess in the right iliac fossa.The gross appear- ances and histology were typical of Crohn's disease.Since then he has remained well apart from a mild recurrence of symptoms in 1980.Mrs SH, born 1933, caucasian, married Mr DH in 1954.A laparotomy was done in September 1965 for pain in the right iliac fossa.Just before surgery a mass had developed in this area.The terminal ileum and caecum were involved in Crohn's disease and a right hemicolectomy undertaken, after which she made a straightforward recovery.She had no further recurrence of this condition but subsequently de- veloped a carcinoma of the breast and died in March 1985 of disseminated malignancy.Crohn's disease in both these patients followed a remarkably benign course and neither had a dis- charge from a sinus or fistula unlike in the report of Rhodes et dl.This is the fifth example and according to Rhodes and coworkers the p value for five or more 'cimetidine and cystic fibrosis' and the quoted papers supporting the benefit of cimetidine should on August 18, 2023 by guest.
Disability and the Future of Medicare
Authors: David M. Cutler
Journal: New England Journal of Medicine (2003)

The forecast aging of the United States — the doubling of the share of the population over 65 years of age in the next 75 years1 — will have profound effects on the medical system. Pessimists worry that the increase in the elderly population will bankrupt the Medicare program; they urge the restructuring of Medicare coverage in order to accommodate the needs of this population.2 Optimists note that medical spending is related to disability more than to longevity. If, as recent data indicate, the aging population not only is living longer but is also healthier,3 then spending for medical care . . .
Lamin A/C Gene Mutation Associated With Dilated Cardiomyopathy With Variable Skeletal Muscle Involvement
Authors: Gary L. Brodsky, Francesco Muntoni, Snjezana Miocic, Gianfranco Sinagra, Caroline Sewry, Luisa Mestroni
Journal: Circulation (2000)

Dilated cardiomyopathy is a form of heart muscle disease characterized by impaired systolic function and ventricular dilation. Familial transmission of the disease is frequently observed, and genetic heterogeneity is indicated by clinical and morphological variability in the disease phenotype. In the family MDDC1 reported here, the disease phenotype is severe and characterized by an autosomal dominant pattern of transmission. In addition, the majority of affected family members show signs of mild skeletal muscle involvement.On the basis of the clinical observation of both cardiac and skeletal muscle abnormalities in the MDDC1 family, the lamin A/C gene was examined in this kindred. Coding regions were polymerase chain reaction-amplified from genomic DNA and sequenced. A single nucleotide deletion was identified within exon 6, and all affected individuals were found to be heterozygous for this deletion.Heterozygosity for a single nucleotide deletion in exon 6 of lamin A/C segregates with both the cardiac and skeletal abnormalities observed in the MDDC1 family.
Reduction of atherosclerosis by administration of dehydroepiandrosterone. A study in the hypercholesterolemic New Zealand white rabbit with aortic intimal injury.
Authors: G B Gordon, D E Bush, H F Weisman
Journal: Journal of Clinical Investigation (1988)

Dehydroepiandrosterone (DHEA) is an endogenous steroid that blocks carcinogenesis, retards aging, and exerts antiproliferative properties. In vitro, it is a potent inhibitor of glucose-6-phosphate dehydrogenase, the first committed step of the pentose phosphate pathway. In man, serum levels of DHEA and its sulfate peak in early adulthood and drop markedly with age. Epidemiologic evidence indicates that low levels of DHEA or its sulfate conjugate are linked to an increased risk of developing cancer or of death from cardiovascular disease. Like cancer, atherosclerosis is a proliferative process characterized by both initiation and promotion phases. This similarity provided a framework in which to study the antiatherogenic effects of DHEA. Rabbits were randomly assigned to four groups. Two groups of rabbits received aortic endothelial injury by balloon catheter and were fed a 2% cholesterol diet for 12 wk. DHEA, 0.5%, was incorporated into the diet of one group receiving the 2% cholesterol diet and endothelial injury and also into the diet of one of the control groups. Animals were killed after 12 wk and aortas, hearts, and livers were studied. Plasma samples were analyzed for total cholesterol, VLDL, LDL, HDL, triglycerides, DHEA, and DHEA-sulfate levels. The atherogenic insult resulted in severe atherosclerosis in animals not treated with DHEA. In those receiving DHEA there was an almost 50% reduction in plaque size (P = 0.006), inversely related to the serum level of DHEA attained. Fatty infiltration of the heart and liver were also markedly reduced. These beneficial actions were not attributable to differences in body weight gain, food intake, total plasma cholesterol or distribution of cholesterol among the VLDL, LDL, or HDL fractions. The results show that high levels of plasma DHEA inhibit the development of atherosclerosis and they provide an important experimental link to the epidemiologic studies correlating low DHEA-sulfate plasma levels with an enhanced risk of cardiovascular mortality.
On the Physical Death of Jesus Christ
Authors: Howard S. Rubenstein
Journal: JAMA (1986)

<h3>To the Editor.—</h3> The article on the physical death of Jesus of Nazareth<sup>1</sup>missed the mark: one simply cannot do an autopsy without a corpse. Even if the New Testament, upon which the authors relied principally for "facts," were historical, it is not unanimous in saying that Jesus was crucified. The Book of Acts, which some scholars consider more ancient than the Gospels, says that Jesus was hanged from a tree.<sup>2</sup>Whether Jesus died during the ordeal is not a new question; there was a period spanning the early Middle Ages when the Church said Jesus did not die, not even physically. I find the authors' use of the term "the Jews" too general, too vague, and too liable to be used for mischief, as it has so often been used in the past 2,000 years. Which Jews did the authors have in mind? Surely not Jesus' original followers,