tbuckley/cabot-search huggingface dataset:
Retrospective blues: Robert Johnson—an open letter to Eric Clapton
Authors: David Connell
Journal: BMJ (2006)

Let us hope the medical profession can continue to learn from all the other worlds that surround it, and which it ultimately serves. Blues aficionados among you may have enjoyed Eric Clapton's Sessions for Robert J— a personal tribute to Robert Johnson, “the most important blues musician who ever lived.”

Session IV of the material featured marvellous acoustic playing by Clapton, emulating his favourite influence, and also his enlightening commentary regarding the difficulty of …
Gastrointestinal Bleeding Due to Worm Infestation, with Negative Upper Gastrointestinal Endoscopy Findings: Impact of Enteroscopy
Authors: None C. Sharma, None K. Bhasin, None S. Bhatti, None Das, None Singh
Journal: Endoscopy (2000)

Background and Study Aims: In cases of hookworm and roundworm infestation, chronic occult bleeding is well known, but acute gastrointestinal bleeding is rarely described. We report five patients with worm infestation who presented with acute massive gastrointestinal bleeding.
Quality of Life and Capsaicin Sensitivity in Patients with Airway Symptoms Induced by Chemicals and Scents: A Longitudinal Study
Authors: Ewa Ternesten-Hasséus, Olle Lowhagen, Eva Millqvist
Journal: Environmental Health Perspectives (2006)

It is common in asthma and allergy clinics to see patients presenting with upper and lower airway symptoms that are induced by chemicals and scents and not explained by allergic or asthmatic reactions. Previous studies have shown that these patients often have increased cough sensitivity to inhaled capsaicin; such sensitivity is known to reflect the airway sensory reactivity. The aim of this study was to evaluate the duration of symptoms induced by chemicals and scents and to measure health-related quality of life (HRQL) in patients with chemically induced airway symptoms. We also wished to determine and compare repeatability of the cough response to capsaicin inhalation, and to evaluate the patients' airway sensory reactivity in a long-term perspective.Seventeen patients with a history of at least 12 months of airway symptoms induced by chemicals and scents were followed over 5 years with repeated questionnaires, measurements of HRQL, and capsaicin inhalation tests.The symptoms persisted and did not change significantly over time, and the patients had a reduced HRQL that did not change during the 5-year period. The capsaicin sensitivity was increased at the start of the study, the cough sensitivity was long-lasting, and the repeatability of the capsaicin inhalation test was considered to be good in a long-term perspective.Upper and lower airway symptoms induced by chemicals and scents represent an entity of chronic diseases, different from asthma or chronic obstructive pulmonary disease, with persistent symptoms, a reduced HRQL, and unchanged sensory hyperreactivity.
Effects of lead on the kidney: roles of high-affinity lead-binding proteins.
Authors: B A Fowler, G DuVal
Journal: Environmental Health Perspectives (1991)

Lead-induced nephropathy produces both tubular and interstitial manifestations of cell injury, but the pathophysiology of these lesions is not completely understood. Delineation of the molecular factors underlying renal handling of lead is one of central importance in understanding the mechanisms of renal cell injury from this agent. Recent studies from this laboratory have identified several distinct high-affinity lead-binding proteins (PbBP) from rat kidney and brain that appear to play critical roles in the intracellular bioavailability of lead to several essential cellular processes in these target tissues at low dose levels. The PbBP from rat kidney has been shown to be a specific cleavage product of alpha 2-microglobulin, which is a member of the retinol-binding protein superfamily. Recent preliminary Western blot and immunohistochemical studies have shown that a polyclonal antibody to the renal PbBP does not recognize the brain PbBP, which appears to be a chemically similar, but distinct molecule. These studies have also shown that the renal PbBP is selectively localized in only certain nephrons and only specific segments of the renal proximal tubule. The striking nephror and cell-type specificity of the localization reaction could result from physiological differences in nephron functional activity or selective molecular uptake mechanisms/metabolism differences that act to define target cell populations in the kidney. In addition, other preliminary studies have shown that short-term, high-dose lead exposure produces increased excretion of this protein into the urine with concomitant decreases in renal concentrations.
Primary subcutaneous follicular centre cell lymphoma with involvement of the galea: a case report and short review of the literature
Authors: D.V. Kazakov, G. Burg, R. Dummer, G. Palmedo, B. Muller, W. Kempf
Journal: British Journal of Dermatology (2002)

Summary Primary cutaneous follicular centre cell lymphoma (FCCL) is a distinct subtype of cutaneous lymphoma that originates from germinal centre cells. Histologically, the disease is typified by a bottom‐heavy infiltrate with a diffuse or follicular growth pattern situated in the mid or deep dermis. In some cases, the neoplastic infiltrate may involve the underlying subcutaneous tissue, but so far primary subcutaneous FCCL has not been reported. We report the first case of primary FCCL located primarily in the deep subcutis with extension into the galea and review the literature on primary subcutaneous B‐cell lymphomas.
Subclinical Biventricular Systolic Function is Impaired in Patients with Systemic Sclerosis: A Speckle Tracking-Based Echocardiographic Study
Authors: Şükrü Taylan Şahin, Şule Yavuz, Neslihan Yılmaz, Betül Cengiz, Selen Yurdakul, Ayşen Bozkurt, Yonca Çağatay, Saide Aytekin
Journal: Journal of the American College of Cardiology (2013)
Tetrahydroaminoacridine and Alzheimer's disease
Authors: E Byrne, T Arie
Journal: BMJ (1994)

of warning bleeds (for example, unexplained bruising, nose bleeds, and umbilical oozing) and often occurs in babies with undiagnosed liver disease.The incidence of intracranial haemorrhage could be much reduced if the grave significance of warning bleeds was always recognised and if, in all babies still jaundiced at 2-3 weeks, underlying liver disease was considered20 and vitamin K status reviewed.Finally, while we continue to debate vitamin K regimens we should be unanimous in promoting breast feeding.
STUDIES ON COLLATERAL CIRCULATION. I. THERMIC CHANGES AFTER ARTERIAL LIGATION AND GANGLIONECTOMY
Authors: Daniel A. Mulvihill, Samuel C. Harvey
Journal: Journal of Clinical Investigation (1931)

The temperature of a part of the body depends largely upon its blood supply.Under certain conditions, the temperature may there- fore be a fair measure of the circulation.With this in view, a series of experiments was planned to approach the problem of collateral circu- lation and eventually the mechanism of vasomotor action.The group of experiments here presented deals with the thermic changes occurring in the hind feet of the dog: (a) following ligation of the external iliac artery, and (b) following ligation of both external iliac arteries and unilateral removal of the tributary sympathetic ganglia.
Pulmonary hypertension in polycythemia vera
Authors: Sucha Nand, Emilio Orfei
Journal: American Journal of Hematology (1994)

Abstract Thromboembolic events occur in about 27% of the patients with polycythemia vera and account for 31% of the deaths. These include cerebrovascular accidents, myocardial infarction, peripheral vascular occlusions, pulmonary infarctions, and venous thrombosis. We report two cases with polycythemia vera who presented with pulmonary hypertension in the absence of previous thromboembolic complications of any kind. One patient died suddenly, with evidence of extensive bilateral thrombosis of prelobular pulmonary arteries at autopsy. In the second patient, local thrombosis in the pulmonary vasculature or recurrent silent pulmonary emboli appear to be responsible for the development of pulmonary hypertension. After institution of anticoagulant therapy, he is able to maintain his functional status. The purpose of this report is to alert clinicians to the development of this insidious, but potentially fatal complication in patients with polycythemia vera. © 1994 Wiley‐Liss, Inc.
Toxicology of chloral hydrate in the mouse.
Authors: V M Sanders, B M Kauffmann, K L White, K A Douglas, D W Barnes, L E Sain, T J Bradshaw, J F Borzelleca, A E Munson
Journal: Environmental Health Perspectives (1982)

Chloral hydrate has been found in our drinking water supplies at levels up to 5 micrograms/1. The purpose of this study was to evalute the acute and subchronic toxicology of chloral hydrate in the random-bred CD-1 mouse, to provide data for risk assessment. The acute oral LD50 of this compound was 1442 and 1265 mg/kg in male and female mice, respectively. Acute toxicity appeared to be related to depression of the central nervous system. Fourteen-day exposure by gavage in male mice at doses 1/10 and 1/100 the LD50 caused an increase in liver weight and a decrease in spleen weight at the highest dose level. Based on the data derived from 14 days of exposure, a 90-day study was performed. The compound was delivered via the drinking water; levels of the compound delivered per day were equivalent to those dosed in the 14-day study. The target organ in both sexes appeared to be the liver, with the males most affected. Male mice demonstrated a dose-related hepatomegaly accompanied by significant changes in serum chemistries and hepatic microsomal parameters. The females did not demonstrate the hepatomegaly observed in males, but did show alterations in hepatic microsomal parameters. No other significant toxicological changes were observed in either sex following 90 days of exposure.
Abstract 354: Conditional inactivation of <i>Pten</i> and overexpression of <i>EGFR</i> in Schwann cells results in early high-grade peripheral nerve sheath tumor development.
Authors: Vincent W. Keng, Adrienne L. Watson, Eric P. Rahrmann, Hua Li, Barbara R. Tschida, Branden S. Moriarity, Kwangmin Choi, Tilat A. Rizvi, Margaret H. Collins, Margaret R. Wallace, Nancy Ratner, David A. Largaespada
Journal: Cancer Research (2013)

Abstract It is hypothesized that many genetic changes are required for the transformation process of sporadic malignant peripheral nerve sheath tumor (MPNST). Currently, Schwann cells and/or their precursor cells are believed to be the primary pathogenic cell source in peripheral nerve sheath tumor (PNST) formation and malignant progression. Recently, it has been shown that phosphatase and tensin homolog (PTEN) and epidermal growth factor receptor (EGFR) both play important roles in the initiation of peripheral nerve sheath tumors (PNSTs). In human MPNSTs, PTEN expression is often reduced, while EGFR expression is often induced. We tested if these two genes cooperate in the evolution of PNSTs, because genetically modified mouse models for each gene alone resulted in the formation of low-grade PNSTs. Transgenic mice were generated carrying conditional floxed alleles of Pten, EGFR was expressed under the control of the 2′,3′-cyclic nucleotide 3’ phosphodiesterase (Cnp) promoter and a desert hedgehog (Dhh) regulatory element driving Cre recombinase transgenic mice (Dhh-Cre). Transgenic mice with EGFR overexpression and Pten inactivated have an early postnatal lethality (median survival age of 26-days) and displayed various peripheral nervous system phenotypes. These mice had multiple enlarged dorsal root ganglia, with high incidence of enlarged brachial plexus and trigeminal nerves at various stages of PNST tumorigenesis. In vitro experiments using immortalized human Schwann cells demonstrated that loss of PTEN and overexpression of EGFR cooperate to increase cellular proliferation and anchorage-independent colony formation. Taken together, our data suggests that reduced PTEN expression, together with EGFR overexpression, can drive malignant progression of low-grade to high-grade PNSTs. Importantly, our novel mouse model recapitulates sporadic human MPNST and will be useful for testing therapies to prevent or reverse tumor progression. Citation Format: Vincent W. Keng, Adrienne L. Watson, Eric P. Rahrmann, Hua Li, Barbara R. Tschida, Branden S. Moriarity, Kwangmin Choi, Tilat A. Rizvi, Margaret H. Collins, Margaret R. Wallace, Nancy Ratner, David A. Largaespada. Conditional inactivation of Pten and overexpression of EGFR in Schwann cells results in early high-grade peripheral nerve sheath tumor development. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 354. doi:10.1158/1538-7445.AM2013-354
MPs told about practical difficulties of full data disclosure
Authors: J. Wise
Journal: BMJ (2013)

MPs examining the topic of clinical trials and data disclosure heard that there may be operational practicalities in the compulsory publication of clinical study reports and raw patient data.

Kent Woods, chief executive of the Medicines and Healthcare Products Regulatory Agency, told the science and technology select committee that he agreed that all trials should be registered and a summary report published. But he added that publishing more detailed information, such as clinical study reports or raw patient data, was more difficult.

Woods said: “They would need to be carefully scrutinised in detail and may need to be redacted in some places, which could be a very labour intensive process.” He added: “We need to give serious consideration [to] how it can be done so it can be useful and operationally …
Simplicity and complexity in health care: what medicine can learn from Google and iPod
Authors: K. Abbasi
Journal: Journal of the Royal Society of Medicine (2005)

Simplicity and complexity in health care: what medicine can learn from Google and iPod 'Everything should be made as simple as possible, but not simpler,' said Albert Einstein.As health care becomes more complex, Einstein's words are being lost.Doctors-be they clinicians or journal editors-are in the communication business and the challenge we face is how to create simplicity out of the complexity of information available to us?Advocates of complexity science argue for the death of Isaac Newton's 'clockwork universe', in which problems are broken down into smaller ones that can be analysed and solved rationally. 1 Complex systems, say these murderers of deduction, have fuzzy, not rigid, boundaries.An insoluble paradox exists between the desire for consistent evidence-based guidelines and the unique requirements of an individual patient.Decision makers are often forced to provide a definitive answer in conditions of high uncertainty, and unthinking adherence to guidelines and protocols can be harmful. 2oes this mean we should stand defeated by complexity?Far from it.Suppliers of information to doctors-and doctors themselves when informing patients-must grapple with complexity to deliver a message of such simplicity that it aids decision making and prevents adverse outcomes.Biologist Edward O Wilson, although unconvinced by complexity theory, suggests that the evolution of complex adaptive systems is based on fundamental simplicities that govern their development. 3In our information-rich and highly complex world, those suppliers of information, and doctors, who succeed will be the ones who make simple sense of our messy world while capturing its fuzziness.But is this some Einsteinian fantasy?How might simplicity defeat complexity?In The Adventure of English Melvyn Bragg argues that it was the simplicity of an alphabet based on twenty-six characters-as well as its ability to absorb other languages-that helped the English language become the lingua franca of the world. 4Juan Enriquez, biotechnologist and founding director of the Harvard Business School Life Science Project, takes this a step further by proposing that English may have triumphed over the infinitely more complex Chinese script but it is now losing out to the superior simplicity of binary code, wherein a sequence of noughts and ones can be given infinite meaning.Enriquez turned his championing of simplicity into a product: The Smallest Ever Guide To Life Sciences (For Busy People) is 28 small, short, and unusually absorbable pages on genes and genomics. 5echnology is one possible answer to medicine's conundrum, although it has made our lives more complex, says the head of Microsoft's desktop applications.A survey in the Economist argued that new technologies begin complex then become simpler, with electricity and the automobile being prime examples. 6 Our simpler future is being arranged as you read.British Telecommunications is
Intracoronary Fibrin-Specific Thrombolytic Infusion Facilitates Percutaneous Recanalization of Chronic Total Occlusion
Authors: Amr E. Abbas, Stacy D. Brewington, Simon R. Dixon, Judith A. Boura, Cindy L. Grines, William W. O’Neill
Journal: Journal of the American College of Cardiology (2005)
“Our Parents, Ourselves”—Reply
Authors: Howard Fillit
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Value of "Hibernation" in Severely Shocked Patients
Authors: S. Kenny
Journal: BMJ (1956)

RECTO-SIGMOID MBRMSH 211 play a part.Strong (1942) quotes Clements and James's view that dietary deficiency, especially in vitamin B2, may play a part, while Shera (1953) blames a vitamin-C deficiency leading to bruising of the bowel.
Early Diabetic Nephropathy: Assessment and Potential Therapeutic Interventions
Authors: Julio Rosenstock, Philip Raskin
Journal: Diabetes Care (1986)

End-stage renal failure secondary to diabetes has increasingly become a health and socioeconomic issue. Diabetic nephropathy is the major cause of death in type I insulin-dependent diabetic patients and accounts for ∼25% of all patients beginning hemodialysis in the United States. Once diabetic nephropathy is well established, attempts to modify the relentless downward progression of the disease have been essentially unsuccessful. We focus on the early structural and functional changes that occur as a consequence of diabetic renal disease and examine the evidence for microalbuminuria as an early marker and predictor for future overt diabetic nephropathy. The rationale for different therapeutic interventions to alter the course of early diabetic nephropathy are discussed.
P1195 PEGYLATED INTERFERON ALPHA 2a PLUS RIBAVIRIN FOR CHRONIC HEPATITIS C IN A REAL-LIFE SETTING: THE “PRACTICE” STUDY IN A TUNISIAN COHORT (2008–2010)
Authors: R. Bouali, N. Abdelli, M. Azzouz, N. Belhadj-Brik, H. Bellil, H. Ben Khalifa, N. Ben Mami, J. Boubaker, H. Douggui, A. Ghorbel, H. Hamza, J. Kharrat, T. Najjar
Journal: Journal of Hepatology (2014)
SOME NEW POINTS ON INFANT FEEDING.
Authors: W. G. A. BONWILL
Journal: JAMA (1899)

The present article is not intended as exhaustive of this subject, which is a very vital one and calls for future investigation, since thousands of lives of infants are ignorantly slaughtered from there having been so little interest taken by the medical profession in the matter, it having been left to manufacturers of nipples as to what is best. While there has been great advance in bacteriologic research, and milk has been Pasteurized and many lives saved, yet there has been no true advance in the improvement of artificial nipples from a humanitarian standpoint. Although more than a thousand different shapes and so-called improvements have been made up to the present; yet, with all that has been brought forth, I found when necessity compelled me to attempt to save the life of one of my grandchildren, no nipple fully met the needs of this case. By an unfortunate mistake in
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
Authors: Vigo Heissmeyer, Fernando Macián, Sin-Hyeog Im, Rajat Varma, Stefan Feske, K Venuprasad, Hua Gu, Yun-Cai Liu, Michael L Dustin, Anjana Rao
Journal: Nature Immunology (2004)
Familial Chronic Lymphocytic Leukemia
Authors: JOSEPH F. FRAUMENI
Journal: Annals of Internal Medicine (1969)

A battery of laboratory tests was applied in the study of a family with chronic lymphocytic leukemia in three sibs, the progeny of a consanguineous mating. Two survivors with leukemia and a sib showed impaired in vitro lymphocyte transformation in response to phytohemagglutinin and selective deficiency of serum immunoglobulin levels. Two other sibs showed only selective immunoglobulin deficiency. The array of findings suggests that a genetically controlled immune mechanism is involved in familial clusters of chronic lymphocytic leukemia.