tbuckley/cabot-search huggingface dataset:
Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety
Authors: V Hoyos, B Savoldo, C Quintarelli, A Mahendravada, M Zhang, J Vera, H E Heslop, C M Rooney, M K Brenner, G Dotti
Journal: Leukemia (2010)
The Polyglandular Syndrome
Authors: RANDY EPSTEIN
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 May 1980The Polyglandular SyndromeRANDY EPSTEIN, B.S., ALLAN T. LUSKIN, M.D., ATHAR RANA, M.D.RANDY EPSTEIN, B.S.Search for more papers by this author, ALLAN T. LUSKIN, M.D.Search for more papers by this author, ATHAR RANA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-5-711_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In response to the recent article by Eisenbarth and colleagues (1), we wish to report a similar case of multiple endocrine disturbances with autoimmune features.Our patient is a 29-year-old white woman with severe insulin-dependent, ketosis-prone diabetes mellitus. Diabetes was originally diagnosed at age 10 years and has been very poorly controlled since. Renal failure developed at age 27 after multiple episodes of pyelonephritis, and she has been on chronic hemodialysis for 6 months. Hypothyroidism was diagnosed at age 10 and treated with supplementation. Secondary amenorrhea began abruptly at age 26 after normal menses at age 17....References1. EISENBARTHWILSONWARDBUCKLEYLEBOVITZ GPFCH. The polyglandular failure syndrome: disease inheritance, HLA type, and immune function: studies in patients and families. Ann Intern Med. 1979;91:528-33. LinkGoogle Scholar2. LERNMARKFREEDMANHOFMANN AZC. Islet-cell-surface antibodies in juvenile onset diabetes mellitus. N Engl J Med. 1978;299:375-80. CrossrefMedlineGoogle Scholar3. DECKERSTEINBERGREINERTSENPLOTZBALOWKLIPPEL JAJPJJ. Systemic lupus erythematosis: evolving concepts. Ann Intern Med. 1979;91:587-604. LinkGoogle Scholar4. MILLERSCHWARTZ KR. Familial abnormalities of suppressor-cell function in systemic lupus erythematosis. N Engl J Med. 1979;301:803-9. CrossrefMedlineGoogle Scholar5. BOTTAZZOFLORIN-CHRISTENSENDONIACH GAD. Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet. 1974;2:1279-82. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rush-Presbyterian-St. Luke's Medical Center Chicago, IL 60612 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCorrection: Polyglandular Syndrome 1 May 1980Volume 92, Issue 5Page: 711-712KeywordsDiabetes mellitusHypothyroidismInsulinPyelonephritisRenal failure Issue Published: 1 May 1980 PDF DownloadLoading ...
An investigation into the enzyme histochemistry of adenocarcinomas of human large intestine and of the transitional epithelium immediately adjacent to them
Authors: J. R. Marsden, I. M. P. Dawson
Journal: Gut (1974)

Histochemical enzymatic studies were performed on 30 freshly resected large bowel carcinomas, 30 samples of normal colonic epithelium, and six samples of the histologically normal epithelium (so-called transitional epithelium) immediately adjacent to a carcinoma. Five enzymes were studied: nicotine adenine dinucleotide tetrazolium reductase (NADH-TR), glucose-6-phosphate dehydrogenase, succinate dehydrogenase, monoamine oxidase, and acid phosphatase. QUANTITATIVE AND QUALITATIVE DIFFERENCES IN ENZYME ACTIVITY WERE OBSERVED BETWEEN NORMAL, TRANSITIONAL, AND CARCINOMATOUS MUCOSA AS FOLLOWS: monoamine oxidase activity was moderate in normal mucosa, high in transitional mucosa, and low in carcinoma. Succinate dehydrogenase activity was high in transitional mucosa and low or moderate in normal and carcinomatous mucosa. Glucose-6-phosphate dehydrogenase activity showed a gradation from low in normal mucosa to high in carcinoma while acid phosphatase showed the reverse of this pattern. The tetrazolium reductase activity was low or moderate in normal and transitional mucosa and high in carcinoma. These differences in enzyme activity and their possible clinical and metabolic significance are discussed.
649 MOLECULAR EPIDEMIOLOGY OF HEPATITIS C VIRUS GENOTYPE 5A IN FRANCE (A MULTICENTRE STUDY ANRS)
Authors: C. Henquell, J. Guglielmini, J. Verbeeck, J.-L. Bailly, R.-J. Perez Serra, M. Van Ranst, K. Randl, G. Bommelaer, H. Peigue-Lafeuille, A. Abergel
Journal: Journal of Hepatology (2010)
Right heart pressure does not equal pericardial pressure in the potassium chloride-arrested canine heart in situ.
Authors: B K Slinker, R V Ditchey, S P Bell, M M LeWinter
Journal: Circulation (1987)

Recently proposed concepts of pericardial surface pressure, as opposed to liquid pressure, have advanced our understanding of the relationship between pericardial and heart chamber pressures. However, the subsequent suggestion that right heart intracavitary pressure equals, or nearly equals, pericardial surface pressure is not strictly consistent with the physiology of pericardial constraint. If right heart pressure equals pericardial surface pressure, then transmural right heart pressure equals zero. Because of the difficulty in measuring pericardial pressure directly in the beating heart we designed an experiment in the recently arrested canine heart in situ to measure pericardial pressure indirectly and to test the hypothesis that right heart transmural pressure is zero under reasonably physiologic, static equilibrium conditions. According to a static equilibrium analysis of the pressures acting across the walls of the heart, at a given volume the change in right heart pressure caused by removing the pericardium is equal to the pericardial pressure when the pericardium is intact. We found that this drop in pressure caused by pericardiectomy did not equal right heart pressure and therefore that right heart transmural pressure does not equal zero.
HÆMORRHAGE OF THE VOCAL CORD.
Authors: E. FLETCHER INGALS
Journal: JAMA (1884)

Hæmorrhage of the vocal cords is so rare that the following case will be of interest to many. The patient, H. B., æt. 45, merchant, came to me during the latter part of October complaining of hoarseness and discomfort in the larynx which had come on suddenly that morning. On rising he had felt perfectly well, but while washing he was suddenly annoyed by a sensation as of some foreign body in the larynx that he described as a "lump in the throat" which troubled him particularly whenever he attempted to swallow. Moderate hoarseness soon supervened. When he called at my office about five hours afterward, the same sensations were still annoying him; he was quite hoarse and a small spot over the thyroid cartilage was tender to the touch. No constitutional symptoms were present. I found the whole left vocal band of a brownishred hue and thickened by sub-mucous
THE TREATMENT OF SPECIFIC AND NONSPECIFIC URETHRITIS BY TOPICAL OLEAGINOUS MEDICATION.
Authors: EUSTATHIUS CHANCELLOR
Journal: JAMA (1892)

So much has been written and published on gonorrhœa that the medical world has a certain distaste for any new literature on the subject; suffice it to say that the numerous nostrums and panaceas for it are nearly as common as the disease is prevalent, and hence I feel a sincere misgiving in even attempting an allusion to this subject, not to say anything of the many benefits to be derived by the novel treatment hereinafter described. More than a year ago, while on a vacation, I was in charge of several hundred men, some of whom were afflicted with the clap, and having but limited means at hand for their treatment, I was in a quandary as to the best method to pursue. The majority of the cases which came under observation were from five to twelve days after incubation, being just about the second period or stage of
A communitywide perspective of sex differences and temporal trends in the incidence and survival rates after acute myocardial infarction and out-of-hospital deaths caused by coronary heart disease.
Authors: R J Goldberg, E J Gorak, J Yarzebski, D W Hosmer, P Dalen, J M Gore, J S Alpert, J E Dalen
Journal: Circulation (1993)

BACKGROUND The purpose of the study was to examine overall differences and temporal trends therein between men and women regarding the incidence rates, in-hospital and long-term survival after initial acute myocardial infarction (AMI), and out-of-hospital deaths caused by coronary disease. METHODS AND RESULTS This nonconcurrent prospective study was carried out in 16 teaching and community hospitals in Worcester, Mass., in six time periods between 1975 and 1988. A total of 3,148 patients hospitalized with validated initial AMI comprised the study sample. The age-adjusted incidence rates of initial AMI increased between 1975 and 1981 in the two sexes, with a marked decrease thereafter; these rates declined by 26% in men and by 22% in women between 1975 and 1988. The overall unadjusted in-hospital case-fatality rates after initial AMI were significantly higher in women (21.7%) than in men (12.7%). Age- and multivariable-adjusted in-hospital case-fatality rates, however, were not significantly different for men compared with women (multivariate-adjusted OR, 0.90; 95% CI, 0.70, 1.16). No clear trends in in-hospital case-fatality rates were observed in men or women over the periods under study. There were no significant sex differences in the age-adjusted long-term survival rates of discharged hospital survivors of AMI. The multivariate-adjusted risk of total mortality among discharged hospital survivors, however, was significantly increased in men (multivariate-adjusted OR, 1.20; 95% CI, 1.03, 1.39); neither of the sexes experienced an improvement over time in long-term prognosis. The incidence rates of out-of-hospital deaths caused by coronary disease declined by 60% in men and 69% in women between 1975 and 1988. CONCLUSIONS The results of this multihospital, community-based study suggest declines in the incidence rates of AMI and out-of-hospital deaths caused by coronary disease in men and women over the period under study (1975-1988). No significant sex differences in in-hospital survival were observed, whereas a poorer long-term survival experience after hospital discharge was observed for men compared with women after controlling for potentially confounding prognostic factors.
Improved Survival Among HIV-Infected Individuals Following Initiation of Antiretroviral Therapy
Authors: Robert S. Hogg
Journal: JAMA (1998)

Context.-Clinical trials have established the efficacy of antiretroviral therapy with double-and triple-drug regimens for individuals infected with the human immunodeficiency virus (HIV), but the effectiveness of these regimens in the population of patients not enrolled in clinical trials is unknown.Objective.-Tocharacterize survival following the initiation of antiretroviral therapy among HIV-infected individuals in the province of British Columbia.Design.-Prospective, population-based cohort study of patients with antiretroviral therapy available free of charge (median follow-up, 21 months).Setting.-Province of British Columbia, Canada.Patients.-AllHIV-positive men and women 18 years of age or older in the province who were first prescribed any antiretroviral therapy between October 1992 and June 1996 and whose CD4 + cell counts were less than 0.350ϫ10 9 /L.Main Outcome Measures.-Rates of progression from initiation of antiretroviral therapy to death or a primary acquired immunodeficiency syndrome (AIDS) diagnosis for subjects who initially received zidovudine-, didanosine-, or zalcitabinebased therapy (ERA-I) and for those who initially received therapy regimens including lamivudine or stavudine (ERA-II).Results.-A total of 1178 patients (951 ERA-I, 227 ERA-II) were eligible.A total of 390 patients died (367 ERA-I, 23 ERA-II), yielding a crude mortality rate of 33.1%.ERA-I group subjects were almost twice as likely to die as ERA-II group subjects, with a mortality risk ratio of 1.86 (95% confidence interval [CI], 1.21-2.86;P=.005).After adjusting for Pneumocystis carinii and Mycobacterium avium prophylaxis use, AIDS diagnosis, CD4 + cell count, sex, and age, ERA-I participants were 1.93 times (95% CI, 1.25-2.97;P=.003) more likely to die than ERA-II participants.Among patients without AIDS when treatment was started, ERA-I participants were 2.50 times (95% CI, 1.59-3.93;PϽ.001) more likely to progress to AIDS or death than ERA-II participants.Conclusion.-The HIV-infected individuals who received initial therapy with regimens including stavudine or lamivudine had significantly lower mortality and longer AIDS-free survival than those who received initial therapy with regimens limited to zidovudine, didanosine, and zalcitabine.
The Relationship between Airways Inflammation and Asthma Severity
Authors: RENAUD LOUIS, LAURIE C. K. LAU, ADRIAAN O. BRON, ALBERT C. ROLDAAN, MAURICE RADERMECKER, RATKO DJUKANOVIĆ
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

In order to investigate the relationship between airways inflammation and disease severity, and improve the understanding of persistent asthma, 74 asthmatics, with disease severity ranging from intermittent, to mild to moderate and severe persistent (classified according to the Global Initiative for Asthma [GINA] guidelines), and 22 nonatopic control subjects were studied using the method of induced sputum. Sputum was analyzed for total and differential cell counts concentrations of albumin, and levels of eosinophil cationic protein (ECP), myeloperoxidase (MPO), and tryptase, inflammatory mediators reflecting eosinophil, neutrophil, and mast cell activation. Asthma severity (assessed by FEV1, peak expiratory flow [PEF] variability, and daily symptom scores) and methacholine airways responsiveness were related to sputum eosinophilia and ECP. In addition, sputum neutrophilia and MPO levels correlated, albeit weakly, with PEF variability and symptom scores, respectively. Tryptase concentrations were raised in mild to moderate asthmatics. Albumin concentrations were significantly raised across the spectrum of asthma severity and correlated with those of tryptase and ECP. Despite treatment with either high doses of inhaled corticosteroids or oral corticosteroids, prominent eosinophilic inflammation with raised ECP was noted. This study points to persistent, disease severity–related airways inflammation in asthma, involving eosinophils, mast cells, and neutrophils, which is evident despite treatment with corticosteroids. Louis R, Lau LCK, Bron AO, Roldaan AC, Radermecker M, DjukanovićR. The relationship between airways inflammation and asthma severity.
Differential expression of nitric oxide synthases in human scalp epidermal and hair follicle pigmentary units: implications for regulation of melanogenesis
Authors: H.M. Sowden, K.M. Naseem, D.J. Tobin
Journal: British Journal of Dermatology (2005)

Nitric oxide (NO) is a ubiquitous gaseous lipophilic molecule generated from the conversion of L-arginine to L-citrulline by the NO synthases (NOSs). Ultraviolet radiation (UVR)-induced NO production appears to stimulate epidermal melanogenesis. However, given their relative protection from UVR, it is unclear whether NO plays a similar role in hair bulb melanocytes.We aimed to identify the expression profiles of the NOS isoforms endothelial NOS (eNOS), neuronal NOS (nNOS) and inducible NOS (iNOS) and of phosphorylated eNOS and nitrotyrosine within the epidermal and follicular melanin units of normal human haired scalp during the hair growth cycle.This study employed single and double immunohistochemical and immunofluorescence staining techniques using haired scalp from 10 healthy individuals (six women and four men).Melanocytes in the basal layer of the epidermis expressed eNOS, nNOS and nitrotyrosine. By contrast, melanogenically active melanocytes of the anagen hair bulb were wholly negative for these markers. However, other follicular melanocytes not actively involved in pigment production, including undifferentiated melanocytes located in the outer root sheath and melanocytes surviving the apoptosis-driven hair follicle (HF) regression during catagen/telogen, expressed eNOS, nNOS and nitrotyrosine. While iNOS was only weakly expressed in the basal layer of the human epidermis, it was highly expressed in keratinocytes of the inner root sheath (IRS), where it colocalized with trichohyalin, a differentiation-associated protein of the IRS that requires enzyme-catalysed conversion of arginine to citrulline.The NOS isoforms and nitrotyrosine are differentially expressed in different cutaneous melanocyte subpopulations. Results of this study suggest a possible role for eNOS, nNOS, iNOS and nitrotyrosine in melanocyte biology, particularly with respect to melanogenesis and melanocyte survival during HF regression. Another example of possible NO involvement in HF biology is the postsynthetic modification of trichohyalin in differentiating keratinocytes of the IRS. These results suggest that NO may influence several aspects of HF biology.
Complementary Value of Two-Dimensional Exercise Echocardiography to Routine Treadmill Exercise Testing
Authors: William F. Armstrong, Jacqueline O'donnell, James C. Dillon, Paul L. McHENRY, Stephen N. Morris, Harvey Feigenbaum
Journal: Annals of Internal Medicine (1986)

Two-dimensional echocardiograms were done during rest and after exercise in 95 patients who subsequently had coronary arteriography. Prior myocardial infarction was present in 36 patients, 35 of whom had wall motion abnormalities. There was no evidence of prior infarction in 59 patients, 44 of whom had coronary disease. In these 44 patients, the exercise electrocardiogram showed ischemia in 19, was normal in 13, and was nondiagnostic in 12. Exercise echocardiograms were abnormal in 35 of these 44 patients. In 15 patients without coronary disease, the treadmill response was nondiagnostic in 6, ischemic in 1, and normal in 8. Exercise echocardiograms were normal in 13 of these 15 patients. We conclude that exercise echocardiography is a valuable addition to routine treadmill testing. It may be of special value in patients with an abnormal resting electrocardiogram or a nondiagnostic response to treadmill testing or when a false-negative treadmill test is suspected.
Current Controversies in Bone Marrow Transplantation
Authors: Daniel Weisdorf
Journal: Annals of Internal Medicine (2000)

Medical Writings: Book Notes5 December 2000Current Controversies in Bone Marrow TransplantationDaniel Weisdorf, MDDaniel Weisdorf, MDUniversity of Minnesota, Minneapolis, Minnesota. (Weisdorf)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-11-200012050-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Bolwell BJ, ed. 322 pages. Totowa, NJ: Humana; 2000. $125.00. ISBN 0896037827. Order phone 973-256-1699.Field of medicine: Clinical bone marrow and stem-cell transplantation.Format: Hardcover book.Audience: Hematologists/oncologists and other physicians interested in bone marrow transplantation.Purpose: To highlight controversial and unresolved issues in bone marrow transplantation.Content: Twenty-one chapters cover transplantation strategies, hematologic malignant disease, solid tumors, and complications of transplantation. Each chapter provides an overview of the critical questions in the field and presents available data or expert opinion in cases where no clear evidence exists.Highlights: The chapters on pediatric acute lymphoblastic leukemia, adult acute lymphoblastic ... Author, Article, and Disclosure InformationAffiliations: University of Minnesota, Minneapolis, Minnesota. (Weisdorf) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 December 2000Volume 133, Issue 11Page: 932KeywordsBone marrowBone marrow transplantationCancer treatmentChronic myelogenous leukemiaOvarian cancerPrecursor cellsSoftware toolsStem cell transplantationSub-specialty careTransplantation ePublished: 5 December 2000 Issue Published: 5 December 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Medicare Payment for Chronic Care Delivered in a Patient-Centered Medical Home
Authors: Andrew B. Bindman, Jonathan D. Blum, Richard Kronick
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bevacizumab and carboplatin increase survival and asymptomatic tumor volume in a glioma model
Authors: Kristoph Jahnke, Leslie L. Muldoon, Csanad G. Varallyay, Seth J. Lewin, Dale F. Kraemer, Edward A. Neuwelt
Journal: Neuro-Oncology (2008)

To evaluate efficacy and MRI findings after intravenous bevacizumab and/or carboplatin in a human glioma animal model, we randomized male nude rats with intracerebral UW28 human glioma xenografts to four groups: (1) controls (n = 9), (2) bevacizumab 10 mg/kg (n = 6), (3) carboplatin 200 mg/m(2) (n = 6), and (4) bevacizumab + carboplatin (n = 6). MRI was performed on the day of treatment (day 7-10) and 1 week later, and rats were followed for survival. Dynamic MRI was done in three controls and three rats treated with bevacizumab with or without carboplatin before and 24 h after treatment. Median overall survival (OS) was as follows: group 1, 16 days; group 2, 23 days; group 3, 22 days; group 4, 36 days. OS was significantly longer in group 4 than in group 1 (p = 0.0011), group 2 (p = 0.0014), and group 3 (p = 0.0015), and rats had significantly larger tumors. No objective tumor responses were observed on MR images at 1 week after treatment; however, after bevacizumab, dynamic MRI showed reduced gadolinium enhancement intensity and increased time to peak, consistent with decreased vascular permeability. Carboplatin + bevacizumab is effective and superior over bevacizumab or carboplatin monotherapy in this animal model. Increased survival concomitant with increased asymptomatic tumor volume is suggestive that vascular targeting with reduced peritumoral edema and mass effect contributes to the efficacy of bevacizumab. The promising survival data warrant future clinical trials using bevacizumab + carboplatin.