tbuckley/cabot-search huggingface dataset:
Meningitis and Skin Reaction after Intravenous Immune Globulin Therapy
Authors: E. Peter Gabor
Journal: Annals of Internal Medicine (1997)

Letters15 December 1997Meningitis and Skin Reaction after Intravenous Immune Globulin TherapyE. Peter Gabor, MDE. Peter Gabor, MDUniversity of California, Los Angeles, School of Medicine; Beverly Hills, CA 90212Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-12-199712150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In his excellent review of high-dose intravenous immune globulin (IVIg) therapy for neurologic diseases, Dalakas [1] states that aseptic meningitis complicating the administration of IVIg responds to analgesics and subsides in 24 to 48 hours and that further diagnostic testing is rarely necessary. In our experience, the symptoms of severe meningeal irritation, high temperature, and vomiting in such cases mandate at least a lumbar puncture for cerebrospinal fluid analysis and possibly other tests. Even if one suspects that meningism could be due to administration of IVIg rather than coincident with it, the possibility of bacterial meningitis should ...References1. Dalakas MC. Intravenous immune globulin therapy for neurologic diseases. Ann Intern Med. 1997; 126:721-30. Google Scholar2. Gabor EP. Intravenous immune globulin. West J Med. 1995; 162:277-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of California, Los Angeles, School of Medicine; Beverly Hills, CA 90212 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIncidence and natural history of intravenous immunoglobulin-induced aseptic meningitis: a retrospective review at a single tertiary care centerRisks associated with the use of intravenous immunoglobulin 1 1This review article reflects the opinions of the authors and not necessarily those of the U.S. Food and Drug Administration.Lichenoid/Interface Cutaneous Eruptions to IVIg with the Primary Infusion May Be Related to the Re-Regulation of Anti-Idiotype Network 15 December 1997Volume 127, Issue 12Page: 1130KeywordsChronic lymphocytic leukemiaDecision makingGlobulinsHospitalizationsLumbar punctureMeningitisMultiple myelomaSkin reactionTemperatureVomiting Issue Published: 15 December 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
A Multi-Country Non-Inferiority Cluster Randomized Trial of Frontloaded Smear Microscopy for the Diagnosis of Pulmonary Tuberculosis
Authors: Luis Eduardo Cuevas, Mohammed Ahmed Yassin, Najla Al-Sonboli, Lovett Lawson, Isabel Arbide, Nasher Al-Aghbari, Jeevan Bahadur Sherchand, Amin Al-Absi, Emmanuel Nnamdi Emenyonu, Yared Merid, Mosis Ifenyi Okobi, Juliana Olubunmi Onuoha, Melkamsew Aschalew, Abraham Aseffa, Greg Harper, Rachel Mary Anderson de Cuevas, Kristin Kremer, Dick van Soolingen, Carl-Michael Nathanson, Jean Joly, Brian Faragher, Stephen Bertel Squire, Andrew Ramsay
Journal: PLoS Medicine (2011)

Luis Cuevas and colleagues report findings from a multicenter diagnostic clinical trial in tuberculosis, showing that the sensitivity and specificity of a "front-loaded" diagnostic scheme is not inferior to that of a standard diagnostic scheme.
Cholesterol, triglyceride, and phospholipid content of intima, media, and atherosclerotic fatty streak in human thoracic aorta.
Authors: W Insull, G E Bartsch
Journal: Journal of Clinical Investigation (1966)

The importance of lipids in the pathogenesis of atherosclerosis in man remains obscure, although the accumulation of lipids has long been acknowledged as closely associated with the lesions of the disease. The hypothesis that gross fatty streak lesions occur early in the sequence of pathogenesis provides a significant guide to the study of this disease (1, 2). Comprehensive knowledge about the lipids of the fatty streak lesions would form a firm basis for comparative study of the role lipids play in potentially precursive and successive lesions. At present, the characterization of fatty streak lipids, including their distribution and concentration in arterial tissue, is incomplete. This is due primarily to differences among the published studies in classification of the lesions, methods of tissue sampling, and choice of normal tissue specimens for control analyses. Few analyses have specifically distinguished the lipids of normal intima, normal media, and the fatty streak lesions of atherosclerosis (3-6). This paper reports analyses of cholesterol, phospholipid, and triglyceride in the fatty streak lesions and grossly normal tissues from thoracic aortas of a homogenous group of 11 male subjects and a
Inhibition of Late Vein Graft Neointima Formation in Human and Porcine Models by Adenovirus-Mediated Overexpression of Tissue Inhibitor of Metalloproteinase-3
Authors: Sarah J. George, Clinton T. Lloyd, Gianni D. Angelini, Andrew C. Newby, Andrew H. Baker
Journal: Circulation (2000)

Autologous saphenous vein coronary artery bypass graft surgery is complicated by late graft failure due to neointima formation and subsequent atherosclerosis. Growth factors and metalloproteinases (MMPs) act in concert to promote neointima formation. Tissue inhibitor of metalloproteinase-3 (TIMP-3), an extracellular matrix-associated MMP inhibitor, uniquely promotes apoptosis of isolated vascular smooth muscle cells. Here, we overexpressed TIMP-3 at the luminal surface of human saphenous veins before organ culture and in pig saphenous veins before interposition grafting into carotid arteries in vivo to assess neointima formation.In both models, high TIMP-3 immunoreactivity occurred in the luminal and upper medial extracellular matrix after adenovirus delivery. MMP activity measured by in situ zymography was reduced throughout the veins, confirming a bystander effect. By use of 3 independent techniques, apoptosis levels in the neointima and medial layer were significantly elevated by TIMP-3 overexpression. Neointima formation was reduced by 84% in 14-day human organ cultures and by 58% in 28-day pig vein grafts (both P<0.05). In contrast, TIMP-2 overexpression had no effect on neointima formation in vivo.Our results highlight the potential therapeutic benefit for TIMP-3 overexpression to reduce neointima formation associated with late vein graft failure.
U.S. Governors and the Medicaid Expansion — No Quick Resolution in Sight
Authors: Benjamin D. Sommers, Arnold M. Epstein
Journal: New England Journal of Medicine (2013)

Since the Supreme Court ruling on the Affordable Care Act, states have been grappling with the question of whether to participate in the expansion of Medicaid eligibility. In the aftermath of the 2012 election, how this process will play out is uncertain.
A NEW PRINCIPLE OF CURING CLUB-FOOT IN SEVERE CASES IN CHILDREN A FEW YEARS OLD
Authors: A. Ogston
Journal: BMJ (1902)

have been rapidly effected by incisions into the knee-joint and the evacuation of the cgntained pus without any further accumulations of pus taking place.Perhaps it is a little premrature to publish a solitary instance of a treatment which, so far as I am aware, is original, but the possibility that, under similar circum- stances, a life might be spared or even a limb saved by the early publication of this single case must be my excuse for the course I have taken.
Near death experience.
Authors: L. Appleby
Journal: BMJ (1989)

factors through regression equations has led to the ability to express as a percentage an applicant's likelihood of success in training.'Four years ago the system was computerised for both the application and the scoring of results, which has opened the way to much further development.New tests, when confirmed and introduced, will give the air force selectors refinements for judging applicants' likelihood of success in training and service.Furthermore, the tests often provide evidence that is valuable in deciding the candidates' suitability for specialties other than those initially considered.All this is particularly important when training methods have to be improved to cope with the rapidly rising demands of technology despite fixed or diminishing budgets.Several years must elapse before the results of applying selection techniques to surgical trainees will be available.Meanwhile others may wish to follow the example of the Royal College of Surgeons and a few medical schools in attempting to provide more objective and scientific methods for selecting those who will take medicine into the next century.
Risk of Nonaccidental and Cardiovascular Mortality in Relation to Long-term Exposure to Low Concentrations of Fine Particulate Matter: A Canadian National-Level Cohort Study
Authors: Dan L. Crouse, Paul A. Peters, Aaron van Donkelaar, Mark S. Goldberg, Paul J. Villeneuve, Orly Brion, Saeeda Khan, Dominic Odwa Atari, Michael Jerrett, C. Arden Pope, Michael Brauer, Jeffrey R. Brook, Randall V. Martin, David Stieb, Richard T. Burnett
Journal: Environmental Health Perspectives (2012)

Few cohort studies have evaluated the risk of mortality associated with long-term exposure to fine particulate matter [≤ 2.5 μm in aerodynamic diameter (PM(2.5))]. This is the first national-level cohort study to investigate these risks in Canada.We investigated the association between long-term exposure to ambient PM(2.5) and cardiovascular mortality in nonimmigrant Canadian adults.We assigned estimates of exposure to ambient PM(2.5) derived from satellite observations to a cohort of 2.1 million Canadian adults who in 1991 were among the 20% of the population mandated to provide detailed census data. We identified deaths occurring between 1991 and 2001 through record linkage. We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for available individual-level and contextual covariates using both standard Cox proportional survival models and nested, spatial random-effects survival models.Using standard Cox models, we calculated HRs of 1.15 (95% CI: 1.13, 1.16) from nonaccidental causes and 1.31 (95% CI: 1.27, 1.35) from ischemic heart disease for each 10-μg/m(3) increase in concentrations of PM(2.5). Using spatial random-effects models controlling for the same variables, we calculated HRs of 1.10 (95% CI: 1.05, 1.15) and 1.30 (95% CI: 1.18, 1.43), respectively. We found similar associations between nonaccidental mortality and PM2.5 based on satellite-derived estimates and ground-based measurements in a subanalysis of subjects in 11 cities.In this large national cohort of nonimmigrant Canadians, mortality was associated with long-term exposure to PM(2.5). Associations were observed with exposures to PM(2.5) at concentrations that were predominantly lower (mean, 8.7 μg/m(3); interquartile range, 6.2 μg/m(3)) than those reported previously.
Abstract 2020: Suppression of Twist expression sensitizes human non-small cell lung cancer (NSCLC) cells to cisplatin
Authors: In-Chul Park
Journal: Cancer Research (2012)

Abstract Twist, a highly conserved basic helix-loop-helix transcriptional factor, is a major inducer of epithelial-mesenchymal transition (EMT) and involved in different phases of tumorigenicity. The elevated Twist expression in cancer cells has been shown to promote metastasis and induce chemoresistance. In this study, we have investigated the mechanism of action by which Twist depletion induces chemosensitivity of lung cancer cells to chemotherapeutic agent. We found that knock-down of Twist expression by siRNAs sensitized H1299 cells to cisplatin by inhibiting mTOR activity. Inhibition of mTOR pathway using mTOR or S6K siRNAs led to potentiate cell death in cisplatin resistant H1299 cells. Our results suggest that suppression of Twist expression sensitized NSCLC cells to cisplatin treatment by down-regulating mTOR pathway. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2020. doi:1538-7445.AM2012-2020
Activation of the hepatocarcinogen aflatoxin B1 by forms of human hepatic cytochromes P-450: Some do and some don't
Authors: Herbert L. Bonkovsky
Journal: Hepatology (1991)

Twelve forms of human hepatic cytochrome P-450 were expressed in hepatoma cells by means of recombinant vaccinia viruses. The expressed P-450's were analyzed for their abilities to activate the potent hepatocarcinogens aflatoxin B1 to metabolites having mutagenic or DNA-binding properties. Five forms, P-450's IA2, IIÁ3, IIB7, IIIA3, and IIIA4, activated aflatoxin B1 to mutagenic metabolites as assessed by the production of His revertants of Salmonella typhimurium in the Ames test. The same P-450's catalyzed conversion of aflatoxin B1 to DNA-bound derivatives as judged by an in situ assay in which the radiolabeled carcinogen was incubated with cells expressing the individual P-450 forms. Seven other human P-450's, IIC8, IIC9, IID6, IIE1, IIIA5, and IVB1, did not significantly activate aflatoxin B1 as measured by both the Ames test and the DNA-binding assay. Moreover, polyclonal anti-rat liver P-450 antibodies that crossreact with individual human P-450's IA2, IIA3, IIIA3, and IIIA4 each inhibited aflatoxin B1 activation catalyzed by human liver S-9 extracts. Inhibition ranged from as low as 10% with antibody against IIA3 to as high as 65% with antibody against IIIA3 and IIIA4. These results establish the metabolic activation of aflatoxin B1 in human liver involves the contribution of multiple forms of P-450.
Abstract PR04: DNA-PK inhibition resensitizes ovarian cancer cells to cisplatin in vivo and is associated with modulation of AKT pathway signaling
Authors: Azadeh Cheraghchi-Bashi-Astaneh, Camila H. De Sousa, Elaina Maginn, Yan Dai, Harpreet Wasan, Gordon B. Mills, Hani Gabra, Euan A. Stronach
Journal: Clinical Cancer Research (2013)

Abstract Sustained proliferative signaling and resisting cell death are two fundamental hallmarks of cancer. The AKT pathway is a frequently aberrant, highly interconnected, intracellular signaling network that connects a wide variety of cell stimuli to proliferative and apoptotic cellular control. We have shown that inappropriate control of the AKT pathway underlies failure of chemotherapy in ovarian cancer and furthermore have shown that DNA-PKcs, a component of the non-homologous-end-joining DNA repair pathway, phosphorylates AKT on serine residue 473 in the nucleus of platinum resistant ovarian tumor cells, but not sensitive cells from the same patient. DNA-PK mediated AKT activation in chemoresistant cells results in inhibitory phosphorylation of the pro-apoptotic protein BAD and stabilization of the anti-apoptotic Bcl-2 protein. We report that inhibition of DNA-PK restores response to cisplatin in chemoresistant ovarian cancer cells in vivo. SKOV3 tumor xenografts were implanted subcutaneously into the flanks of Balb/c nu/nu mice and treated with 7.5mg/kg or 10mg/kg DNA-PKcs inhibitor, NU7441 daily (5days on/2 days off) for 2 weeks alone or in combination with 1mg/kg cisplatin twice weekly. DNA-PK inhibition or cisplatin alone were ineffective however in combination decreased tumor growth at 14 days by 89% (7.5mg/kg NU7441) and 90% (10mg/kg NU7441), relative to platinum only treatment. Tumor xenografts were recovered and analyzed by reverse phase protein array (RPPA). Analysis has revealed AKT pathway signaling alterations that underlie the enhanced response to cisplatin on addition of NU7441. DNA-PK inhibition is an attractive therapeutic strategy for resensitizing resistant tumors to platinum based therapy, directly linking the DNA damage caused by platinum to the pro-survival AKT pathway. This abstract is also presented as Poster A50. Citation Format: Azadeh Cheraghchi-Bashi-Astaneh, Camila H. De Sousa, Elaina Maginn, Yan Dai, Harpreet Wasan, Gordon B. Mills, Hani Gabra, Euan A. Stronach. DNA-PK inhibition resensitizes ovarian cancer cells to cisplatin in vivo and is associated with modulation of AKT pathway signaling. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr PR04.
FLUID LIMITATION AND KETOGENIC DIET IN TRAUMATIC EPILEPSY
Authors: H. D. Palmer
Journal: JAMA (1930)

In the brief period that has elapsed since the introduction of the dietary control of epilepsy, a vast literature has accumulated dealing with various phases of the subject. More recently, following the work of Fay 1 on the hydraulic mechanisms involved in cerebrospinal fluid production, circulation and absorption in the normal and in convulsive states, dehydration has become one of the prime factors in the control of the epilepsies. The relationship between fluid intake and convulsive seizures has been investigated by Fay and Winkelman. 2 Their work has resulted in the formulation of the mechanical theory of epilepsy. McQuarrie 3 has announced some significant clinical results obtained by the treatment of epileptic patients with a combination of the ketogenic diet and fluid limitation.  Up to the present time the literature dealing with these modes of treatment has not sufficiently emphasized their application in the so-called traumatic epilepsy. Fay 4 has
Characterization of pigmented granules in minocycline-induced cutaneous pigmentation: observations using fluorescence microscopy and high-performance liquid chromatography
Authors: N. OKADA, S. SATO, T. SASOU, M. AOYAMA, K. NISHIDA, K. YOSHIKAWA
Journal: British Journal of Dermatology (1993)

We describe a technique to facilitate histopathological detection and quantitative measurement of trace amounts of tissue minocycline. In a patient with minocycline-induced hyperpigmentation, a series of biopsies were taken from the affected skin over a period of 54 months, and examined for tissue minocycline deposition. Frozen sections treated with 1 M MgCl2-ethanol yielded minocycline-specific yellowish fluorescence, the location of which corresponded to clumps of granular deposits in the dermis. A decrease in the number of fluorescent granules correlated with the clinical resolution of hyperpigmentation and a significant decrease in the tissue minocycline level. Our data also provide further support for the concept that the pigment granules contain insoluble complexes of minocycline chelated with iron. The fluorescence technique is simple, sensitive, and reproducible.
The growth of medical thought.
Authors: Owsei Temkin
Journal: JAMA (1963)

The curative successes of recent decades often have led to a wholesale condemnation of older medicine. Critics do not always realize that the ridicule heaped upon older practices throws a peculiar light upon the practitioners. Were they fools, whereas we are wise? Few will be ready to give an affirmative answer to this question. Once we grant that what looks absurd to us was not done and thought by fools, we shall be prepared to look for an explanation of the seemingly ridiculous. We shall try to understand the medical thought of past ages within the context of the times. This is the position taken by Dr. King in the present book, which is particularly concerned with pathogenesis. Instead of covering all times and places, the author has selected a number of key figures. Apollo, Asclepius, and Hippocrates stand for the path "from religion to science." Galen, with his doctrine
ST. GEORGE'S HOSPITAL: CASES OF PARALYSIS OF THE FACIAL NERVE
Authors: T. Holmes
Journal: BMJ (1856)

A88OCUTION MEDICAL JOURHAL.[A.ItL 19, 1IM.tho eyeball, after Bonnet's method, will matally shorten the patient's sufferings, and enable him to resume his em- ployment earlier than when partial excision is performed.CABs xxii.S. D., 36 years of
Narrow band imaging with magnification for the characterization of small and diminutive colonic polyps: pit pattern and vascular pattern intensity
Authors: J. East, N. Suzuki, P. Bassett, M. Stavrinidis, H. Thomas, T. Guenther, P. Tekkis, B. Saunders
Journal: Endoscopy (2008)

See also: Commentaire de travail de J. E. East et al., pp. 811Endoscopy 2008; 40(10): 970-971DOI: 10.1055/s-0032-1306880
CYTOCHROME P450 2C19 LOSS-OF-FUNCTION POLYMORPHISM AND CARDIOVASCULAR EVENTS IN PATIENTS TREATED WITH DRUG-ELUTING STENT
Authors: Il-Young Oh, Chang-Hwan Yoon, Seung-Jung Park, Kyung-Woo Park, Hae-Young Lee, Hyun-Jai Cho, Hyun-Jai Kang, Hyo-Soo Kim
Journal: Journal of the American College of Cardiology (2010)
Training in Heart Auscultation
Authors: Antonio Guijarro Morales
Journal: Annals of Internal Medicine (1991)

Letters15 June 1991Training in Heart AuscultationAntonio Guijarro Morales, MDAntonio Guijarro Morales, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-12-1065_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Cardiac auscultation must be done in a compulsive, systematic way, with the physician listening intently for one event at a time (1). Auscultation focuses more on the timing of events within the cardiac cycle than on their intensity or on the site at which they are heard best (2).Training in heart auscultation should begin with teaching the student to identify the first sound, perceived simultaneously with the carotid pulse (3). This can be taught only on an individual basis. We use a flash of light—either video-recorded or emitted in real time—that is presented simultaneously with the...References1. ShaverSalerni JR. Auscultation of the heart. In: Hurst JW, Schlant RC, Rackley CE, Sonnenblick EH, Wenger NK, eds. Arteries and Veins. 7th ed. New York: McGraw-Hill;1990:176. Google Scholar2. SolokowMcllroyChetlin MMM. Clinical Cardiology. 5th ed. Norwalk, Connecticut: Appleton & Lange; 1990:56. Google Scholar3. DelmanStein AE. Dynamic cardiac auscultation and phonocardiography. Philadelphia: W.B. Saunders; 1979:62. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: School of Medicine University of Granada E-18071 Granada Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1991Volume 114, Issue 12Page: 1065-1066KeywordsAuscultationHeartHeart rate Issue Published: 15 June 1991 PDF DownloadLoading ...
A FIELD HOSPITAL IN BELGIUM
Authors: J. H. Beavis, H. S. Souttar
Journal: BMJ (1915)

JAN. 9, T9I5 which the amount of work a muscle was asked to do was usually in excess of cell recovery; the resumption of work shlould be gradual-that is, presumably witlh cell recovery.The treatment of the muscle is all-essential in the disease.Inistead of waiting fQr a chance recovery in the cornual cells and treating in a perfunctory way tlle muscles with massage and electricity, we recognize tllat every affected muscle will woirk, provided tllat a commencement be made from zero.It is recognized, that an affected limb will retain its heat and slhow little waste provideol that it be rested and worked witllin physiological limitations.Work muLst not be done for the muscle, it must itself work.In coneltusion, I would like to mention certain references that to me stand as landmarks-namelv, Hunter's lectures on muscular mDotion, perhaps the master's greatest work; Hughlings Jackson, who taught us tlle application of Darwvin's work to tlle nervous system; and Owen Thomas, wh1o pointed out the significance of surgical rest.It is to tlhc credit of this great man that he placed his back against the tide that unfortunately tlle antiseptic system loosened, and Australia owes a no small debt to my teaclher, Dr. Peter Bennie of this city, for hiis unswerving support durinig the last thirty years of Thomas's work.