tbuckley/cabot-search huggingface dataset:
Abstract 4395: Targeting ribosomal proteins for therapeutic inhibition of melanoma growth.
Authors: Gregory R. Kardos, Gavin P. Robertson
Journal: Cancer Research (2013)

Abstract Disruption of ribosome biogenesis leads to the activation of the RP-MDM2-p53 pathway along with other yet to be identified pathways. Ribosome biogenesis is inherently tied to protein synthesis, a process relied upon in cancer to sustain its increased proliferative properties. The ability to activate a tumor suppressor and simultaneously target a process heavily dependent upon for cancer growth is a promising therapeutic angle that deserves exploration. In the present study, we knocked down expression of all large subunit ribosomal proteins to examine their effect on melanoma growth. We found that targeting many ribosomal proteins lead to decreased cancer cell viability. siRNA mediated knocking down of RPL13, a representative ribosomal protein of this group, resulted in increased p53 expression and cell cycle arrest dependent on the RP-MDM2-p53 pathway. Furthermore, inhibition of protein synthesis in culture and decreased tumor growth by 50-90% in animals was observed upon knockdown of RPL13. We conclude that the cell cycle arrest is due in large part to the increased p53 expression caused by the binding of RPL5 and RPL11 to MDM2, however the inhibition of melanoma growth cannot be explained solely by an increase in the tumor suppressor. The accompaniment of decreased protein synthesis provides an additional mechanism contributing to decreased growth. Thus, targeting ribosomal proteins in cancer may serve as an underappreciated therapeutic treatment. Citation Format: Gregory R. Kardos, Gavin P. Robertson. Targeting ribosomal proteins for therapeutic inhibition of melanoma growth. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4395. doi:10.1158/1538-7445.AM2013-4395
Let’s Show Patients Their Mental Health Records
Authors: Michael W. Kahn, Sigall K. Bell, Jan Walker, Tom Delbanco
Journal: JAMA (2014)

Should we health professionals encourage patients with mental illness to read their medical record notes? As electronic medical records and secure online portals proliferate, patients are gaining ready access not only to laboratory findings but also to clinicians’ notes.1 Primary care patients report that reading their doctors’ notes brings many benefits including greater control over their health care, and their doctors experience surprisingly few changes in workflow. 2 While patients worry about electronic records and potential loss of privacy, they vote resoundingly for making their records more available to them and often to their families.
From the Authors
Authors: R. Chavasse
Journal: European Respiratory Journal (2003)

Noseclips in children performing spirometryTo the Editor: CHAVASSE et al. [1] evaluated the use of noseclips in children performing spirometry.They found that there was no clear benefit of using noseclips in children performing open-circuit spirometry.They also stated that their literature search found no studies addressing this issue.However, in 1997 our group published a similar study, which also showed no clear benefit with noseclips [2].We randomised 80 adults and 81 children (59 with asthma, 12 with cystic fibrosis, and 22% with airways obstruction) to perform forced expiratory spirometry with and without noseclips.We found no significant differences between values obtained with noseclips versus without noseclips.When we performed a Medline search, using noseclips as the keyword, our study was not identified.Apparently the journal in which it was published, Respiratory Care, was not included in Medline until the year 2000.Thus, there are at least two studies rather than one that indicate that the routine use of noseclips is not necessary in children performing routine spirometry.
GENERAL SEPTIC PERITONITIS TREATED WITH SEPTICEMIC SERUM.
Authors: W. A. MACFARLANE
Journal: JAMA (1896)

Mrs. H., age 30; general health fairly good; eight years ago gave birth at the eighth month to a healthy child; it lived three days. She became pregnant in about one year and at end of third month miscarried. About five years ago was called to see her for the first time. On examination found os dilated to some extent, with double laceration of cervix; most extensive on left side. Found patient had had considerable hemorrhage. Decided to prevent miscarriage if possible, as they were anxious to have children. Succeeded in stopping the hemorrhage to some extent before leaving. Was called the next morning in great haste; found her considerably prostrated from loss of blood and flowing profusely. Decided at once to dilate and deliver, which was done as rapidly as possible, but not until she was very much prostrated, being obliged to use a number of hypodermic injections of
Sexual Health Promotion in General Practice
Authors: T A Carney
Journal: BMJ (1995)

Ed Hilary Curtis, Tony Hoolaghan, Carey Jewitt Radcliffe, £15, pp 144 ISBN 1 85775 131 0

Although major thrusts of health promotion by national advertising campaigns can achieve a little, there is a great deal of evidence that specific advice from the patient's own general practitioner is the most potent way of promoting health. Sexual Health Promotion in General Practice is a welcome addition to doctors' education in this topic.

The book states that 26% of general practitioners and 20% of community nurses are uneasy when talking to patients about explicit sexual matters. I may …
Unilateral Clubbing and Cyanosis of Toes
Authors: Lewis P. Scott
Journal: JAMA (1965)

<h3>To the Editor:—</h3> Clubbing of the digits has intrigued observers throughout medical history. Just-Viera<sup>1</sup>has recently summarized the current theories of etiology and associated findings. Unilateral clubbing is particularly unusual and prompts the recording of the following patient. A 6-year-old white female was referred for evaluation of cyanosis and clubbing of the toes of her left foot. She was the product of a pregnancy terminated prematurely by cesarean section for placenta praevia. At birth she was noted to have clubbing and cyanosis of all toes of the left foot. There were large tortuous veins on the dorsal and lateral surfaces of the foot, and a small subcutaneous nodule on the dorsum of the left third toe. Growth and development were normal. The only change in the foot was disappearance of the cyanosis of the great toe. There were no symptoms referable to the abnormality, and no family history of
Characterization of nontransmural myocardial infarction by positron-emission tomography.
Authors: E M Geltman, D Biello, M J Welch, M M Ter-Pogossian, R Roberts, B E Sobel
Journal: Circulation (1982)

The present study was performed to determine whether positron emission tomography (PET) performed after i.v. 11C-palmitate permits detection and characterization of nontransmural myocardial infarction. PET was performed after the i.v. injection of 11C-palmitate in 10 normal subjects, 24 patients with initial nontransmural myocardial infarction (defined electrocardiographically), and 22 patients with transmural infarction. Depressed accumulation of 11C-palmitate was detected with sagittal, coronal and transverse reconstructions, and quantified based on 14 contiguous transaxial reconstructions. Defects with homogeneously intense depression of accumulation of tracer were detected in all 22 patients with transmural infarction (100%). Abnormalities of the distribution of 11C-palmitate in the myocardium were detected in 23 patients with nontransmural infarction (96%). Thallium scintigrams were abnormal in only 11 of 18 patients with nontransmural infarction (61%). Tomographically estimated infarct size was greater among patients with transmural infarction (50.4 +/- 7.8 PET-g-Eq/m2 [+/- SEM SEM]) compared with those with nontransmural infarction (19 +/- 4 PET-g-Eq, p less than 0.01). Residual accumulation of 11C-palmitate within regions of infarction was more intensely depressed among patients with transmural compared to nontransmural infarction (33 +/- 1 vs 39 +/- 1% maximal myocardial radioactivity, p less than 0.01). Thus, PET and metabolic imaging with 11C-palmitate is a sensitive means of detecting, quantifying and characterizing nontransmural and transmural myocardial infarction.
The Use of Aprepitant in Brachioradial Pruritus
Authors: Mina S. Ally, Christina S. Gamba, David H. Peng, Jean Y. Tang
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
A Philosophical Approach to Diagnostic Test Evaluation
Authors: Sarah J. Lord, Les Irwig, R. John Simes
Journal: Annals of Internal Medicine (2007)

Letters15 May 2007A Philosophical Approach to Diagnostic Test EvaluationSarah J. Lord, MBBS, MS, Les Irwig, MBBCh, PhD, and R. John Simes, MBBS, MS, MDSarah J. Lord, MBBS, MSFrom The University of Sydney, Camperdown, New South Wales 2050, Australia.Search for more papers by this author, Les Irwig, MBBCh, PhDFrom The University of Sydney, Camperdown, New South Wales 2050, Australia.Search for more papers by this author, and R. John Simes, MBBS, MS, MDFrom The University of Sydney, Camperdown, New South Wales 2050, Australia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-10-200705150-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Dr. Sonke and colleagues that one purpose of test accuracy studies is to determine whether the test provides accurate information about long-term clinical outcomes, that is, what is the prognostic value of the test information? We also agree that an ideal study to achieve this purpose is one in which the reference standard is a good proxy for patient outcome. In the absence of effective treatment, this information would be all that is required. However, if treatment is available, we also need to ask whether the test identifies patients whose outcomes would be improved by ...References1. Lijmer JG, Bossuyt PM. Diagnostic testing and prognosis: the randomised controlled trial in diagnostic research.. In: Knottnerus JA, eds. The Evidence Base of Clinical Diagnosis. London: BMJ Books; 2002:61-80. Google Scholar2. Palareti G, Cosmi B, Legnani C, Tosetto A, Brusi C, Iorio A, et al. D-dimer testing to determine the duration of anticoagulation therapy. N Engl J Med. 2006;355:1780-9. [PMID: 17065639] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Sarah J. Lord, MBBS, MS; Les Irwig, MBBCh, PhD; R. John Simes, MBBS, MS, MDAffiliations: From The University of Sydney, Camperdown, New South Wales 2050, Australia.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoWhen Is Measuring Sensitivity and Specificity Sufficient To Evaluate a Diagnostic Test, and When Do We Need Randomized Trials? Sarah J. Lord , Les Irwig , and R. John Simes A Philosophical Approach to Diagnostic Test Evaluation Gabe S. Sonke , André L.M. Verbeek , and Lambertus A.L.M. Kiemeney Metrics 15 May 2007Volume 146, Issue 10Page: 757-758KeywordsAnticoagulant therapyConflicts of interestD-dimerDeep vein thrombosisMorbidityMortalityPatientsSafety ePublished: 15 May 2007 Issue Published: 15 May 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Editing the ERJ: an observational study
Authors: K. F. Rabe, P. J. Sterk
Journal: European Respiratory Journal (2005)

We know that we are usually the first to underline the importance of evidence for any claim made by authors submitting their work to our Journal, but at this point in our editorship of the European Respiratory Journal ( ERJ ), we thought it worthwhile to share with you some recent observations we have made.

Information that is not based on randomised trials can be very valid and has gained considerable attention recently. It is recognised as a credible form of research with the potential to reveal unexpected mechanisms of disease in general and to present unwanted side-effects of the intervention in question 1. In essence, it is a form of reflection and this is what we as your Editors have been doing over the past 3 years.

In case you have not already realised, we have been supporters of observational studies for quite some time, and regularly publish this form of information in the ERJ ; case presentations and cases for diagnosis are prime examples. The Journal has a long history of presenting interesting observations (attention readers and connoisseurs of editorial strategies: don't worry, we will resist the temptation to cite them all at this point since this is not our intention when writing editorials) and we have continued to do this for some very good reasons. Together with Erik Berglund, who has been indispensable in this process for many years (and we simply dread the prospective that he might ever stop supporting us), and in contrast to some other journal editors, we believe that these cases are an important part of the Journal's content.

Whilst we do not have hard evidence to support this, we do think that our readers take a strong interest in these case studies and cases for diagnosis (as is suggested by on average 8,227 …
Real-time visualization of pH-responsive PLGA hollow particles containing a gas-generating agent targeted for acidic organelles for overcoming multi-drug resistance
Authors: Cherng-Jyh Ke, Wei-Lun Chiang, Zi-Xian Liao, Hsin-Lung Chen, Ping-Shan Lai, Jui-Sheng Sun, Hsing-Wen Sung
Journal: Biomaterials (2012)
SUBACUTE THYROIDITIS
Authors: Robert J. Vanderlinde
Journal: JAMA (1960)

Subacute thyroiditis often escapes recognition, although the diagnosis is easy if the possibility is kept in mind. Of the 13 cases summarized here, only 6 were diagnosed by the first physician who saw the patient, and in 3 cases it was the fourth physician who made the diagnosis. The most important diagnostic clue was palpation of the thyroid, which would often have sufficed to distinguish between thyroiditis and pharyngitis. The disease is generally self-limited, and patients with mild cases need only aspirin. Steroid therapy is purely symptomatic. In most patients it brings about relief from pain, swelling, and fever within the first day or two. One patient had relapses on three occasions when it was discontinued or the dose lowered prematurely.
Stimulation of globin synthesis: relative responsiveness of reticulocytes and nucleated erythroid cells
Authors: Herbert S. Waxman
Journal: Journal of Clinical Investigation (1970)

The effects of iron, cobalt, hemin, and plasma on hemoglobin synthesis by suspensions of rabbit reticulocytes and nucleated bone marrow cells were studied. L-Leucine-(14)C and sodium pyruvate-3-(14)C were employed to measure globin and heme synthesis, respectively. Normal plasma (or serum) was found to stimulate the rate of globin synthesis in both systems. The stimulatory effects of iron and hemin were additive to those of plasma or serum only in the reticulocytes. Cobaltous ion, at concentrations less than 1.0 mmole/liter, was found to stimulate globin synthesis by reticulocytes as effectively as ferrous ion; cobalt was inhibitory only at concentrations greater than 3.0-5.0 mmoles/liter. Heme synthesis by reticulocytes was inhibited at all concentrations employed (0.2-5.0 mmoles/liter). In bone marrow nucleated erythroid cells, globin synthesis was markedly enhanced by exogenous hemin. In contrast to reticulocytes, however, bone marrow cells were unresponsive to either cobalt or transferrin-bound iron. Possible implications of these findings on regulation of the rate and mechanism of iron uptake and hemoglobin synthesis in vivo are discussed.
Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells
Authors: Alexander Roesch, Adina Vultur, Ivan Bogeski, Huan Wang, Katharina M. Zimmermann, David Speicher, Christina Körbel, Matthias W. Laschke, Phyllis A. Gimotty, Stephan E. Philipp, Elmar Krause, Sylvie Pätzold, Jessie Villanueva, Clemens Krepler, Mizuho Fukunaga-Kalabis, Markus Hoth, Boris C. Bastian, Thomas Vogt, Meenhard Herlyn
Journal: Cancer Cell (2013)
Avascular necrosis of bone after adult acute lymphocytic leukemia treatment with methotrexate, vincristine, L-asparaginase, and dexamethasone (MOAD)
Authors: Laifong Hui, Peter H. Wiernik
Journal: American Journal of Hematology (1996)

Four of 55 (7%) adult acute lymphocytic leukemia patients, age 27–58 years, who were treated with methotrexate, vincristine, L-asparaginase, and dexamethasone (MOAD) developed avascular necrosis (AVN) of one or both femoral heads 16–39 months after beginning treatment. All patients were treated with total joint replacement without compromise of quality of life during more than 3–9 years of follow-up, and they have remained in complete remission for a total of 6.5+ to 10.5+ years. A review of the literature revealed 11 previously reported cases of AVN of bone in patients with acute lymphocytic leukemia, 10 of whom received dexamethasone. The patients in the present report received a total dexamethasone dose equivalent to that of prednisone, 3.4–5.0 g/M2. Although AVN of bone has been reported in patients receiving chemotherapy without corticosteroids, corticosteroids appear to be the most common class of agents associated with its development, and dexamethasone treatment may be more likely to result in AVN of bone than other corticosteroids, for unknown reasons. © 1996 Wiley-Liss, Inc.
Non-myeloablative transplantation with CD8-depleted or unmanipulated peripheral blood stem cells: a phase II randomized trial
Authors: E Willems, F Baron, E Baudoux, N Wanten, L Seidel, J-F Vanbellinghen, C Herens, A Gothot, P Frère, C Bonnet, K Hafraoui, G Vanstraelen, G Fillet, Y Beguin
Journal: Leukemia (2008)
Variant cell lines selected for alterations in the function of the hyaluronan receptor CD44 show differences in glycosylation.
Authors: J Lesley, N English, A Perschl, J Gregoroff, R Hyman
Journal: The Journal of Experimental Medicine (1995)

CD44 is a major cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan (HA). However, the ability of CD44 to bind ligand is strictly regulated. Three activation states of CD44 have been demonstrated: (a) inactive; (b) inducible (by certain CD44-specific mAb); and (c) constitutively active. Starting with two parental cell lines expressing CD44 in the inactive state, a pre-B cell (RAW 253) and a fibroblast (L cells), we used fluorescence-activated cell sorting with fluorescein-conjugated hyaluronan in the presence of inducing mAb to derive variant cell lines with CD44 in the inducible state. Constitutively active derivatives were isolated from the inducible variants by a further round of fluorescence-activated cell sorting in the absence of inducing antibody. However, constitutively active variants could not be isolated directly from parental cells expressing CD44 in the inactive state. These results suggest that two genetic events must occur to obtain an active CD44-HA receptor from an inactive receptor. Variant and parental cell-derived CD44 molecules exhibited differences in migration on sodium dodecyl sulfate-polyacrylamide gel electrophoresis that were partly attributable to differences in N-linked glycosylation. Furthermore, culture in tunicamycin for 2-3 d converted parental and inducible cell lines into cells showing constitutive CD44-mediated HA binding. Also, removal of cell surface glycosaminoglycan chains by culture of cells in p-nitrophenyl beta-D-xylopyranoside or treatment with chondroitinase ABC resulted in conversion of cells with an inactive CD44 receptor to an inducible state. These results indicate that carbohydrate side chains of CD44 and/or other molecules on the cell surface that interact with CD44 are potentially involved in regulating the HA-binding function of CD44 on the cell surface.
ATS/ERS international multidisciplinary consensus classification of the idiopathic interstitial pneumonias
Authors: M. Demedts, U. Costabel
Journal: European Respiratory Journal (2002)

In the January issue of the American Journal of Respiratory and Critical Care Medicine the “ATS/ERS international multidisciplinary consensus classification of idiopathic interstitial pneumonias” 1 was published, and this certainly deserves an editorial comment in the European Respiratory Journal (ERJ). Previously, several classifications have been proposed, of which the most influential were the landmark histological classification of chronic interstitial pneumonias by Liebow and Carrington 2 and Liebow 3, and the recent updates of acute and chronic idiopathic interstitial pneumonias (IIP) by Katzenstein and Myers 4 and by Muller and Colby 5.

A correct histological classification is of utmost importance based on the fact that prognosis and survival vary largely depending on the subset of IIP 6–8. Pathology-based diagnoses are, however, only available in a minority of patients with IIP, since the majority do not undergo surgical lung biopsy. Conversely, it has been shown that high-resolution computed tomography (HRCT) scanning, in particular, but also other clinical features, may be of discriminative diagnostic value 5, 9–11. Therefore, integrated clinical, radiological and histological classifications and definitions are mandatory. In response to this, the American Thoracic Society (ATS) and the European Respiratory Society (ERS) recently published an international consensus statement focusing on idiopathic pulmonary fibrosis (IPF), with guidelines on diagnosis and …
PROBLEMS OF THE AGING: CONCLUSIONS DERIVED FROM TWO YEARS OF INTERDISCIPLINARY STUDY OF DOMICILIARY MEMBERS IN A VETERANS ADMINISTRATION CENTER
Authors: ERNEST J. FOGEL, EMIL R. SWEPSTON, SYLVESTER S. ZINTEK, CLAIRE M. VERNIER, JOHN F. FITZGERALD, RICHARD S. MARNOCHA, CHARLES H. WESCHLER
Journal: American Journal of Psychiatry (1956)

The problem of domiciliary care is a complex one. Two years of intensive study of a group of long-term domiciliary residents, recent admissions as they come in, and a comparable sample of chronically disabled veterans able to maintain themselves in the community have yielded a wealth of significant data. Through the use of an interdisciplinary research team, it has been possible to integrate medical, physical, social, and psychological findings into a meaningful composite picture. It has also been possible to use the results of the study as a basis for a modified program of operations. The extent to which the current program is successful in providing for a better adjustment of the veteran within the domiciliary or for facilitation of his return to community living is a question to be answered by the projected research program.