Herpes Simplex Encephalitis Treated with Systemic 5-Iodo-2′deoxyuridine
Authors: C. JANE BREEDEN
Journal: Annals of Internal Medicine (1966)

Case Studies1 November 1966Herpes Simplex Encephalitis Treated with Systemic 5-Iodo-2′deoxyuridineC. JANE BREEDEN, A.B., THOMAS C. HALL, M.D., F.A.C.P., H. RICHARD TYLER, M.D.C. JANE BREEDEN, A.B., THOMAS C. HALL, M.D., F.A.C.P., H. RICHARD TYLER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-5-1050 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcute necrotizing encephalitis due to herpes simplex virus can be a fatal or severely debilitating disease (1-4). The outlook is especially poor in those patients in whom the disease progresses to coma and convulsions (1, 2).An analogue of thymidine, 5-iodo-2′deoxyuridine (IUDR), inhibits the growth of herpes simplex and other deoxyribonucleic acid (DNA) viruses in vitro (5, 6) and has been used topically in the treatment of herpes simplex keratitis (7, 8).It has been suggested that systemic IUDR might be helpful in slowing or aborting the progression of potentially lethal systemic viral diseases such as herpes simplex encephalitis (7,...References1. MILLERHESSERTOMPKINS JKFVN: Herpes simplex encephalitis: report of 20 cases. Ann. Intern. Med. 64: 92, 1966. LinkGoogle Scholar2. RAWLSDYCKKLASSGREERHERRMANN WEPJDWHDEC: Encephalitis associated with herpes simplex virus. Ibid., p. 104. Google Scholar3. DRACHMANADAMS DARD: Herpes simplex and acute inclusion-body encephalitis. Arch. Neurol. (Chicago) 7: 45, 1962. CrossrefMedlineGoogle Scholar4. 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SHEARERFINCH MLSM: Periodic organic psychosis associated with recurrent herpes simplex. New Eng. J. Med. 271: 494, 1964. CrossrefMedlineGoogle Scholar22. HUTFIELDCSONKA DCGW: Marboran in herpes genitalis. Lancet 1: 329, 1964. CrossrefMedlineGoogle Scholar23. PIERCELEEDSPORTNOYMORRISONWEHRLE NFNBRP: Encephalitis associated with herpes simplex infection presenting as a temporal-lobe mass: report of 2 cases with survival. Neurology (Minneap.) 14: 708, 1964. CrossrefMedlineGoogle Scholar24. MUKHERJEEBODOHARWENTLANDANSFIELDHEIDELBERGER KLJDFJC: Studies on the fluorinated pyrimidines. XVI. Metabolism of 5-fluorouracil-2-C14 and 5-fluoro2′-deoxyuridine-2-C14 in cancer patients. Cancer Res. 23: 49, 1963. Google Scholar25. MACCOLLUMPOTTEREDWARDS FOJMDH: Early diagnosis of herpes-simplex encephalitis by brain biopsy. Lancet 2: 332, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, MassachusettsFrom the Section of Neurology, Peter Bent Brigham Hospital, and the Departments of Neurology (Peter Bent Brigham and Children's Hospital complex) and Medicine, Harvard Medical School, Boston, Mass.This work was supported in part by grant C6516, National Cancer Institute, National Institutes of Health, Bethesda. Md., and by contract PH-43-62-169 and grant HE-06370, U. S. Public Health Service, Washington, D. C.Requests for reprints should be addressed to H. Richard Tyler, M.D., Department of Neurology, Peter Bent Brigham Hospital, 721 Huntington Ave., Boston, Mass. 02115. 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LAUTER, M.D.Intermittent Recurring PsychosesAntiviral agents as adjuncts in cancer chemotherapyHerpesvirus hominis5-Iodo-2′-DeoxyuridineSystemic and Topical Use of Poly I.C. in Treatment of Generalized Neonatal Herpes Simplex Infection with Severe Ocular InvolvementKomplikationen und supportive Therapie der Leukämien und malignen Non-Hodgkin-LymphomeAcute necrotizing encephalitisPerfusion and Molecular Modification of Idoxuridine to Alter Its Cerebrospinal Fluid MetabolismAdenine Arabinoside Therapy of Biopsy-Proved Herpes Simplex EncephalitisHerpes Simplex EncephalitisUptake of 5( 125 I) iodo-2-Deoxyuridine (IDU) in Plasma and Cerebrospinal Fluid in a Case of Herpes Encephalitis with a Comparative Study on the Uptake in Plasma, Cerebrospinal Fluid and Brain Tissue in DogsBrain electrical activity of rabbits with experimental herpetic encephalitisHerpes simplex-Encephalitis bei NeugeborenenThe management of ocular herpesvirus infectionsHerpes simplex encephalitis in hodgkin's disease.Isolation of drug-sensitive virus from brain following unsuccessful treatment with idoxuridineNeonatal Disseminated Herpes Simplex Virus Infection with Encephalitis Treated with Cytosine ArabinosideFailure of High Dose 5-Iodo-2′-Deoxyuridine in the Therapy of Herpes Simplex Virus EncephalitisHalogenated Pyrimidine DeoxyribonucleosidesChapter 17. Antiviral AgentsThe Current Status of the Laboratory Diagnosis of Viral Diseases of ManThe angiographic and brain scan findings in acute non-herpetic encephalitisImmunofluorescence staining for the diagnosis of herpes encephalitisViral Infections of the Central Nervous SystemThe angiographic and brain scan features of acute herpes simplex encephalitisManagement of acute leukemiaUse of cancer chemotherapeutic agents in non-neoplastic diseasesHerpes simplex encephalitis in an anergic patientViral encephalitisThe Design of Biologically Active NucleosidesAcute Viral EncephalitisIsotope encephalography in the management of acute herpesvirus encephalitisRadiological findings in herpes simplex encephalitisViral infections in patients with malignant diseasesTHE ELECTROENCEPHALOGRAM IN HERPES-SIMPLEX ENCEPHALITISAcute necrotizing encephalitis complicating bifrontal craniotomy and pituitary curettageNew indications for 6-azauridine treatment in man. A reviewOn the Role of Viruses in Acute Infectious Diseases of the Central Nervous System: Clinical and Laboratory Studies on Hospitalized PatientsREFERENCESIDUの眼, 体内および胎児への移行に関する研究Approaches to antiviral chemotherapyCOAGULATION DEFECTS IN THE NEWBORNE.E.G. IN HERPES-SIMPLEX ENCEPHALITISInfectious Complications of Neoplastic DiseaseTHERAPEUTICS XIV.Diagnosis and treatment of herpes encephalitisDEXAMETHASONE TREATMENT IN HERPES-SIMPLEX ENCEPHALITISHerpes simplex encephalitis: Virologic and serologic study of a patient treated with an interferon inducerHerpesvirus InfectionsTHE EFFECT OF IODO-DEOXYURIDINE ON HERPES SIMPLEX VIRUS ENCEPHALITIS IN ANIMALS AND MANTHE EFFECT OF IDOXURIDINE ON THE EXCRETION OF CYTOMEGALOVIRUS IN CONGENITAL INFECTION5-Iodo-2′-deoxyuridine in neonatal herpesvirus hominis encephalitisELECTROENCEPHALOGRAPHY IN DIAGNOSIS OF HERPES-SIMPLEX ENCEPHALITISHERPES ENCEPHALITIS TREATED WITH INTRAVENOUS IDOXURIDINEAdvances in the Chemotherapy of Viral DiseasesHerpesvirus hominis Encephalitis in MichiganIdoxuridine in Herpesvirus EncephalitisIDOXURIDINE AND JAUNDICETHE OMOHYOID SYNDROMESome Recent Developments in VirologyPERFORATION OF A TUBERCULOUS BLADDERDRUGS AGAINST VIRUSESHerpes encephalitis: I. The clinical pictureThe EEG in progressive multifocal leukoencephalopathyENCEPHALITISHerpes simplex encephalitis: Brain biopsy andtreatment with 5-iodo-2′-deoxyuridineAkut bedrohliche InfektionskrankheitenHerpesvirus Infections of the Human Central Nervous SystemEncephalitis Caused by Herpes-Simplex VirusEncephalitis: A Variable Syndrome in Response to Viral InfectionNeurosurgical Experiences with Herpes Simplex EncephalitisBrain scan in a patient with herpes simplex encephalitisHERPES SIMPLEX ENCEPHALITIS TREATED WITH IDOXURIDINE AND EXTERNAL DECOMPRESSIONACUTE NECROTISING ENCEPHALITISThe Clinical Significance of Cytomegalovirus Infection in Renal Transplant RecipientsDAVID RIFKIND, PH.D., M.D., NEAL GOODMAN, M.D., ROLLA B. HILL JR., M.D.AZAURIDINE IN VIRAL EYE INFECTIONSORAL CONTRACEPTIVES AND DEPRESSIONRADIATION MYOPATHYInfectious diseases. Annual review of significant publications. 1 November 1966Volume 65, Issue 5Page: 1050-1056KeywordsComaDNA virusesElectron microscopyEncephalitisHerpes simplexHospital medicineMedical servicesNeurologyThymidinesViral diseases Issue Published: 1 November 1966 PDF downloadLoading ...