tbuckley/cabot-search huggingface dataset:
Vitamin E and Cardiovascular Health
Authors: Rita F. Redberg
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Strategies for the Treatment of Acute Psychosis
Authors: William H. Anderson
Journal: JAMA (1974)

Acute-onset psychosis is a medical emergency that requires vigorous and immediate treatment. The cornerstone of appropriate initial management is the timely use of high-potency antipsychotic chemotherapy. Under such a regimen, the psychosis may show substantial remission within a few hours. Hospital treatment may thus be averted, obviating the problems of social opprobrium, pessimism, and high cost. Inpatient treatment is necessary if the patient is suicidal or homicidal, if there is question of delirium, if there is no viable family or social support, or if the psychosis does not clear rapidly. Subsequent careful follow-up is required to avoid the pitfalls of reactivated psychosis and medication excessive in dose or duration. (<i>JAMA</i>229:1884-1889, 1974)
An observational study comparing quality of care in walk-in centres with general practice and NHS Direct using standardised patients
Authors: C. Grant
Journal: BMJ (2002)

<h3>Abstract</h3> <b>Objectives:</b> To compare the quality of clinical care in walk-in centres with that provided in general practice and by NHS Direct. <b>Design:</b> Observational study involving assessment of clinicians by standardised patients. <b>Setting:</b> 20 walk-in centres, 20 general practices, and 11 NHS Direct sites. <b>Participants:</b> 297 consultations with standardised patients, 99 in each setting, carried out by professional role players trained to play five clinical scenarios (postcoital contraception, chest pain, sinusitis, headache, and asthma). <b>Main outcome measures:</b> Primary outcomes were mean scores on consensus derived checklists of essential items for the management of the clinical scenarios. Data were also collected on access to and referral by walk-in centres, general practices, and NHS Direct. <b>Results:</b> Walk-in centres achieved a significantly greater mean score for all scenarios combined than general practices (difference between groups 8.2, 95% confidence interval 1.7 to 14.6) and NHS Direct (10.8, 5.5 to 16.1). There was considerable between scenario variation, with walk-in centres performing particularly well on postcoital contraception and asthma scenarios. In contrast to general practices, walk-in centres and NHS Direct referred a higher proportion of patients (26% and 82%, respectively). <b>Conclusion:</b> Walk-in centres perform adequately and safely compared with general practices and NHS Direct for the range of conditions under study, but the impact of referrals on workload of other healthcare providers requires further research. <h3>What is already known on this topic</h3> Assessment of the quality of care provided by walk-in centres is an important part of their overall evaluation The one previous study to assess quality in this setting reported negative findings but was methodologically flawed Standardised patients are a valid and reliable method of assessment of quality of clinical care <h3>What this study adds</h3> Walk-in centres perform adequately and safely compared to general practice and NHS Direct for the range of conditions under study
Persistence of Enlarged Pulmonary Arteries—22 Years After Atrial Septal Defect Closure
Authors: Lawrence A. Gould
Journal: JAMA (1987)

<h3>To the Editor.—</h3> Surgical closure of an atrial septal defect is advised within the first two decades of life. Surgery performed after the age of 20 years is associated with a higher mortality and morbidity. Residual cardiomegaly is seldom seen unless the operation is performed after the second decade of life. Hugely dilated pulmonary arteries also are seldom seen after successful closure of an atrial septal defect. We describe a case that demonstrates the persistence of very enlarged pulmonary arteries 22 years after successful closure of an atrial septal defect. <h3>Report of a Case.—</h3> A 63-year-old man was admitted to the hospital because of dyspnea of two weeks' duration. In 1964, a cardiac murmur was detected by his private physician. A chest roentgenogram showed very enlarged pulmonary arteries. A cardiac catheterization demonstrated an atrial septal defect. He subsequently underwent closure of the defect. There were no postoperative complications. He remained
Abstract 4676: <i>In-vitro</i> adenosine triphosphate-based chemotherapy response assay (ATP-CRA) results comparison between primary and recurrent gynecologic cancer using a unique cohort
Authors: Eun J. Nam, Young Tae Kim, Sang Wun Kim, Sunghoon Kim, Ga Won Yim
Journal: Cancer Research (2014)

Abstract Purpose: The standard chemotherapy regimen in gynecologic cancer treatment is not established, particularly in cases of recurrence. The objective of this study is to evaluate the role of in vitro adenosine triphosphate-based chemotherapy response assay (ATP-CRA) in recurrent gynecologic cancer. Methods: We examined 20 matched primary and recurrent tumor pairs of each patient with recurrent gynecologic cancer, using ATP-CRA. Tumor samples were obtained from primary and secondary debulking or palliative surgery. Inhibition rates of the chemotherapeutic agents were compared. Results: The diseases of patients analyzed in this study were composed of ovarian/peritoneal cancer [11 patients (55%)], uterine cancer [7 patients (35%)], and cervical cancer [3 patients (15%)]. The average of inhibition rate was 36.3% in samples obtained from primary surgery and 33.6% in samples from secondary debulking or palliative surgery (P&amp;gt;0.1). In the primary surgery cases, the drugs showing high inhibition rate were ifosfamide (56.4%), cisplatin (52.6%), and irinotecan (43.3%) in the following order, and in the secondary operation cases, ifosfamide (54.3%), cisplatin (44.3%), and Topotecan (39.9%). The number of cases in which the ATP-CRA result had actual influence in choosing the regimen, were 0 (0%) in primary surgery cases, and 7 (35%) in secondary surgery cases (P&amp;lt;0.05). Conclusion: The drug inhibition rate did not decrease in the recurrent tumors compared to the primary tumors. The actual influence of ATP-CRA results increase significantly in the secondary surgery compared to the primary one. Note: This abstract was not presented at the meeting. Citation Format: Eun Ji Nam, Young Tae Kim, Sang Wun Kim, Sunghoon Kim, Ga Won Yim. In-vitro adenosine triphosphate-based chemotherapy response assay (ATP-CRA) results comparison between primary and recurrent gynecologic cancer using a unique cohort. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4676. doi:10.1158/1538-7445.AM2014-4676
In silico Analysis of the Potential Infection Mechanisms of Magnaporthe grisea from Horizontal Gene Transfer Hypothesis
Authors: Chunyang Li, Ying Wang, Hao Peng, Hejiao Bian, Mingwei Min, Longfei Chen, Qian Liu, Jinku Bao
Journal: Genomics Proteomics & Bioinformatics (2009)

Abstract Horizontal gene transfer (HGT) has long been considered as a principal force for an organism to gain novel genes in genome evolution. Homology search, phylogenetic analysis and nucleotide composition analysis are three major objective approaches to arguably determine the occurrence and directionality of HGT. Here, 21 genes that possess the potential to horizontal transfer were acquired from the whole genome of Magnaporthe grisea according to annotation, among which three candidate genes (corresponding protein accession numbers are EAA55123, EAA47200 and EAA52136) were selected for further analysis. According to BLAST homology results, we subsequently conducted phylogenetic analysis of the three candidate HGT genes. Moreover, nucleotide composition analysis was conducted to further validate these HGTs. In addition, the functions of the three candidate genes were searched in COG database. Consequently, we conclude that the gene encoding protein EAA55123 is transferred from Clostridium perfringens. Another HGT event is between EAA52136 and a certain metazoan’s corresponding gene, but the direction remains uncertain. Yet, EAA47200 is not a transferred gene.
The Changing "Face" of 99mTc-labeled RBC Imaging and Hepatic Hemangioma
Authors: Jingbo Wang, Walter J. Slizofski, Karen Russell, Kiran M. Kapadia, M. Monem Gillan, Simin Dadparvar
Journal: Clinical Nuclear Medicine (1996)

Wang, Jingbo MD.; Slizofski, Walter J. MD.; Russell, Karen CNMT.; Kapadia, Kiran M. MD.; Gillan, M. Monem MD.; Dadparvar, Simin MD Author Information
"Early" Discharge of Low-Birth-Weight Infants
Authors: Robert B. Berg
Journal: JAMA (1969)

In a group of 68 low-birth-weight infants with uncomplicated hospital courses, discharged at a mean weight of 2,041 gm (4 lb 8 oz) after an average hospital stay of 11 days, the incidence of morbidity and of mortality has been found to be zero. None of the infants died nor had any serious illness during a follow-up period which included the first three months of life and the first two months following discharge. A comparison group of 572 low-birth-weight infants with uncomplicated hospital courses were discharged at a mean weight of 2,417 gm (5 lb 5 1/4 oz) after an average hospital stay of 22 days. There are economic implications of the 50% reduction in hospital stay and other potential benefits and hazards to be considered in "early" discharge.
Adventitial Microvessel Formation After Coronary Stenting and the Effects of SU11218, a Tyrosine Kinase Inhibitor
Authors: Asim N. Cheema, Tony Hong, Nafiseh Nili, Amit Segev, John G. Moffat, Kenneth E. Lipson, Anthony R. Howlett, David W. Holdsworth, Michael J. Cole, Beiping Qiang, Frank Kolodgie, Renu Virmani, Duncan J. Stewart, Bradley H. Strauss
Journal: Journal of the American College of Cardiology (2006)
Complex genetic contribution of the Apo AI-CIII-AIV gene cluster to familial combined hyperlipidemia. Identification of different susceptibility haplotypes.
Authors: G M Dallinga-Thie, M van Linde-Sibenius Trip, J I Rotter, R M Cantor, X Bu, A J Lusis, T W de Bruin
Journal: Journal of Clinical Investigation (1997)

Familial combined hyperlipidemia (FCH) is a common genetic lipid disorder in Western societies. In a recent report (Dallinga-Thie, G.M., X.D. Bu, M. van Linde-Sibenius Trip, J.I. Rotter, A.J. Lusis, and T.W.A. de Bruin. J. Lipid Res., 1996, 36:136-147) we have studied three restriction enzyme polymorphisms: XmnI, and MspI sites 5' of the apo AI gene and SstI site in the 3' untranslated region of exon 4 of the apo CIII gene in 18 FCH pedigrees, including 18 probands, 178 hyperlipidemic relatives, 210 normolipidemic relatives, and 176 spouses. DNA variations in the apo AI-CIII-AIV gene cluster had a modifying effect on plasma triglycerides, LDL cholesterol, and apolipoprotein CIII levels. In this study, combinations of haplotypes were analyzed to further characterize their interactions and effect on the expression of severe hyperlipidemia in FCH subjects. A specific combination of haplotypes with one chromosome carrying the X1M1S2 (1-1-2) haplotype and the other the X2M2S1 haplotype (2-2-1) was significantly more frequent in hyperlipidemic relatives (6%) than in normolipidemic relatives (3%) and spouses (0.5%). Associated with this combination of haplotypes were significantly elevated plasma cholesterol (P < 0.0001), triglycerides (P < 0.0001), and apo CIII (P < 0.001) levels when compared to the wild type combination of haplotypes 1-1-1/1-1-1. The only spouse with this specific combination of haplotypes showed a severe hyperlipidemic phenotype, similar to FCH. Furthermore, nonparametric sibpair linkage analysis revealed significant linkage between these markers in the gene cluster and the FCH phenotype (MspI P = 0.0088, SstI P = 0.044, and XMS haplotype P = 0.037). The present findings confirm that the apo AI-CIII-IV gene cluster contributes to the FCH phenotype, but this contribution is genetically complex. An epistatic interaction between different haplotypes of the gene cluster was demonstrated. The S2 allele on one haplotype was synergistic to the X2M2 allele on the other haplotype in its hyperlipidemic effect. Therefore, two different susceptibility loci exist in the gene cluster, demonstrating the paradigm of complex genetic contribution to FCH.
Multiple Fistulas and Tracheobronchial Stenoses Require Extensive Stenting of the Central Airways and Esophagus in Squamous-Cell Carcinoma
Authors: C. Witt, M. Ortner, R. Ewert, B. Schmidt, L. Steiniger, G. Baumann, H. Lochs, B. Schreiber
Journal: Endoscopy (1996)

We report here on two cases of double airway and esophageal stenting in patients with multiple esophagotracheal fistulas and stenoses of the airways and esophagus due to squamous-cell carcinoma. Dumon stents and a Strecker device were used for tracheobronchial stenting. Covered Gianturco Z-stents were implanted into the esophagus. In one case, extrinsic compression of the trachea and tumor progression required recanalization by Nd:YAG laser. Clinical improvement led to discharge of the patients within two weeks after the procedure.
FEASIBILITY AND SAFETY OF AORTIC VALVE PLASTY UTILIZING AN AUTOLOGOUS PERICARDIAL PATCH IN PATIENTS WITH AORTIC REGURGITATION
Authors: Takenori Otsuka, Makoto Suzuki, Hisao Yoshikawa, Youko Ishikawa, Takako Tsuchida, Tsukasa Osaki, Masayoshi Matsuyama, Hiromasa Yamashita, Shin Uchida, Go Hashimoto, Masao Moroi, Masato Nakamura, Shigeyuki Ozaki, Kaoru Sugi
Journal: Journal of the American College of Cardiology (2011)
149. Transient Kupffer Cell Saturation, Via Adenovirus or Adenoviral Protein, Enhances Expression of Reporter Virus
Authors: Viraj P. Mane, Christian Clarke, Lali Medina-Kauwe, Milton Finegold, Brendan Lee
Journal: Molecular Therapy (2005)

Gene therapy vectors derived from adenoviral serotypes are efficacious both in vitro and in vivo, and are active in murine, canine, bovine and primate models. The development of gene-deleted Helper-Dependent Adenoviral vectors (HDAd) has attenuated chronic toxicity while improving transgene expression persistence. Nevertheless, early immune responses are raised against adenoviral vectors in a dose-dependent manner. Depending on dose, acute toxicity of the vector may culminate in a lethal proinflammatory condition in all model organisms including human.
Junior doctors oppose 48 hour limit for all Junior doctors want guidelines on study leave BMA warns Liberal Democrats about shortage of doctors More specialties move into new grade BMA NOTICES
Authors: L. Beecham
Journal: BMJ (1996)

# Junior doctors oppose 48 hour limit for all {#article-title-2}

Junior hospital doctors have conceded that a limit of a 48 hour working week would be impractical for all doctors. At present doctors in training are excluded from the European Union's directive on working time, which specifies a 48 working week. The European Commission is expected to issue a white paper shortly setting out options for the excluded groups. Many junior doctors believe that they should be included but the BMA's Junior Doctors Committee has decided that its policy will remain the target set out in the new deal on hours of work—that is, that by 31 December no junior doctor should be working for more than 56 hours.

The decision will please those surgical trainees who had criticised the new deal for reducing their training opportunities and believed that the JDC was not representing their interests. The JDC has already agreed to negotiate and promote the use of the “English clause” which enables trainees in appropriate specialties to be contracted for a maximum average of up to 83 hours a week—their hours of actual work should not, however, exceed 56.

The deputy chairman for hours of work and manpower, Dr Andrew Hobart, supported a motion from a surgical research registrar—“This committee does not wish to see a 48 hour limit on hours of work to be applied to all junior doctors.” There was a case for limiting the hours of preregistration house officers but it would not, he said, “be in the best interest of doctors to restrict hours to …
Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for Lymph Node Staging in Patients with Non-small Cell Lung Cancer in Nonoperable Patients Pursuing Radiotherapy as a Primary Treatment
Authors: Takahiro Nakajima, Kazuhiro Yasufuku, Mio Nakajima, Masayuki Baba, Kyosan Yoshikawa, Tadashi Kamada, Kenzo Hiroshima, Yukio Nakatani, Takehiko Fujisawa, Ichiro Yoshino
Journal: Journal of Thoracic Oncology (2010)
Clinical features of non-tuberculous constrictive pericarditis
Authors: H. Ikram, S. O. Banim, A. R. Makey
Journal: Thorax (1974)

<b>Ikram, H., Banim, S. O., and Makey, A. R. (1974).</b><i>Thorax</i>, <b>29</b>, 204-208. <b>Clinical features of non-tuberculous constrictive pericarditis.</b> This paper describes the clinical features of five cases of constrictive pericarditis of non-tuberculous aetiology. The findings in this syndrome are compared with those in tuberculous constrictive pericarditis. The non-tuberculous variety had a short history, and absence of ascites and third heart sounds. Pericardial calcification, paradoxical arterial pulse, and the marked `y9 descent in the venous pulse were absent in contrast to tuberculous constriction. An atrial sound was usual and the chief venous wave was the `a9 wave. The difficulty in diagnosing this type of pericardial constriction and its differentiation from `restrictive9 cardiomyopathy is discussed. It is suggested that all currently available diagnostic techniques are liable to failure and, if in doubt, a diagnostic thoracotomy is mandatory.
Development of Esophageal Cancer after Endoscopic Injection Sclerotherapy for Esophageal Varices: Three Case Reports
Authors: M. Ohta, H. Kuwano, M. Hashizume, T. Sonoda, M. Tomikawa, H. Higashi, S. Ohno, M. Watanabe, K. Sugimachi
Journal: Endoscopy (1995)

We report here three cases of squamous-cell carcinoma of the esophagus following endoscopic injection sclerotherapy for esophageal varices. All three patients were men and cigarette smokers, with a mean age of 58.3 ± 5.0 years. Hepatitis B and C virus infection tests were negative, and alcoholic cirrhosis was present in each patient. The interval between sclerotherapy and the development of carcinoma was 9, 10, and 33 months, in the respective cases. The sclerosant used was 5 % ethanolamine oleate with a mean total volume of 51.0 ± 18.9 ml. While we have no evidence of a direct relationship between sclerotherapy and esophageal cancer, in patients with alcoholic cirrhosis who have risk factors for esophageal cancer there may be an acceleration of the potential malignancy, as a result of the chronic inflammation related to sclerotherapy. Such patients should be closely followed, using endoscopy.
Innervation of Nasal Turbinate Blood Vessels in Rhinitic and Nonrhinitic Children
Authors: JUAN MANUEL FIGUEROA, ENRIQUE MANSILLA, ANGELA MARÍA SUBURO
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

An immunohistochemical study of the nasal mucosa was done in pediatric patients attending an otorhinolaringology (ORL) clinic. The goal was a comparison between vascular innervation in patients with or without symptoms of chronic rhinitis. All patients had an indication for tonsillectomy prior to their inclusion in this study. Samples were obtained under general anesthesia at the time of programmed surgery and fixed in a paraformaldehyde-picric acid mixture. Cryostat sections were immunostained for the following neuronal markers: protein-gene product 9.5 (PGP), calcitonin gene- related peptide (CGRP), substance P (SP), and C-terminal peptide of neuropeptide Y (CPON). The following classes of vessels were identified: arteries, sinusoids, veins, and arteriovenous anastomoses (AVAs). As shown by immunostaining with the general neuronal marker PGP, each vessel type had a characteristic innervation pattern, differing in the amount of fibers and their distribution within the adventitial and muscle layers. Evaluation of PGP, CPON, and CGRP immunoreactivity patterns indicated that rhinitic arteries and AVAs displayed a richer innervation than did nonrhinitic blood vessels. Quantification of vascular PGP immunostaining confirmed the difference of vascular innervation between nonrhinitic and rhinitic patients. Fibers immunostained by CPON partially accounted for the rhinitic arterial hyperinnervation.
Diastolic left ventricular filling patterns in diastolic versus systolic congestive heart failure of the elderly: The cardiovascular heart study
Authors: John S. Gottdiener, Gerard P. Aurigemma, Dalane W. Kitzman, Alice M. Arnold, Cheryl S. Egher, Karen M. Fowle, Jeffrey C. Hill
Journal: Journal of the American College of Cardiology (2003)