Respiratory and Cardiac Arrest After Intravenous Administration of Kanamycin with Reversal of Toxic Effects by Neostigmine
Authors: CHARLES R. REAM
Journal: Annals of Internal Medicine (1963)

Case Studies1 September 1963Respiratory and Cardiac Arrest After Intravenous Administration of Kanamycin with Reversal of Toxic Effects by NeostigmineCHARLES R. REAM, M.D.CHARLES R. REAM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-3-384 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this report is threefold: [1] to alert physicians to the curare-like effects that kanamycin may have on patients when it is administered intravenously; [2] to acquaint them with circumstances that may contribute to toxicity; and [3] to inform them as to the use of effective antidotes. Kanamycin is often used intravenously when a patient is critically ill with a serious infection. In such a patient kanamycin may, because of its generalized neuromuscular blockage, cause respiratory insufficiency and eventually respiratory arrest.CASE REPORTThis 16-year-old white female was admitted to Saint Elizabeth Hospital for the first time on...References1. DOREMUS WP: Respiratory arrest following intraperitoneal use of neomycin. Am. Surg. 149: 546, 1959. Google Scholar2. ENGELDENSON HLJS: Respiratory depression due to neomycin. Surgery 42: 862, 1957. MedlineGoogle Scholar3. FERRARAPHILLIPS BERD: Respiratory arrest following administration of intraperitoneal neomycin. Amer. Surg. 23: 710, 1957. MedlineGoogle Scholar4. GLIEDMANSELLERSSPIERGRANTBISTALKARLSON MLRDNRNBLKE: Respiratory arrest following intraperitoneal administration of neomycin: experimental study. Surg. Forum 9: 404, 1958. MedlineGoogle Scholar5. MCCORKLE RG: Neomycin toxicity: A case report. Arch. Pediat. 75: 439, 1958. MedlineGoogle Scholar6. PITTINGERLONGMILLER CBJPJR: The neuromuscular blocking action of neomycin: a concern of the anesthesiologist. Anesth. Analg. 37: 276, 1959. Google Scholar7. STECHISHINVOLOSHINALLARD OPCCA: Neuromuscular paralysis and respiratory arrest caused by intrapleural neomycin. Canad. Med. Ass. J. 81: 32, 1959. MedlineGoogle Scholar8. PITTINGERLONG CBJP: Danger of intraperitoneal neomycin during ether anesthesia. Surgery 43: 445, 1958. MedlineGoogle Scholar9. TIMMERMANLONGPITTINGER JCJPCB: Neuromuscular blocking properties of various antibiotic agents. Toxic. Appl. Pharmacol. 1: 299, 1959. CrossrefMedlineGoogle Scholar10. IWATSUKIUEDAYAMADANISHIMURAKANEMARU KTASK: Effects of streptomycin on the action of muscle relaxants. Med. J. Shinshu. Univ. 3: 299, 1958. Google Scholar11. IWATSUKIUEDAYAMADANISHIMURAKANEMARU KTASK: Effects of kanamycin on the action of muscle relaxants. Ibid., 311. Google Scholar12. MULLETTKEATS RDAS: Apnea and respiratory insufficiency after intraperitoneal administration of kanamycin. Surgery 49: 350, 1961. Google Scholar13. FISK GC: Respiratory paralysis after large dose of streptomycin: report of case. Brit. Med. J. 1: 556, 1961. CrossrefMedlineGoogle Scholar14. SABAWALADILLON PBJB: The action of some antibiotics on the human intercostal nerve-muscle complex. Anesthesiology 20: 659, 1959. CrossrefMedlineGoogle Scholar15. BROWNLEEBUSHBY GSR: Chemotherapy and pharmacology of aerosbovin. Lancet 1: 131, 1948. CrossrefGoogle Scholar16. CORCORANIMPERIALSMITH ACESHE: Neurogenic hypertension: Sequel of kanamycin intoxication. JAMA 174: 1838, 1960. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Elizabeth, New JerseyFrom Saint Elizabeth Hospital, Elizabeth, New Jersey.Requests for reprints should be addressed to Charles R. Ream, M.D., Physician in Chief, Saint Elizabeth Hospital, Elizabeth, New Jersey. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByChemical composition and acetylcholinesterase inhibitory potential, in silico, of Myrciaria floribunda (H. West ex Willd.) O. 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