A single, annual, high dose of oral vitamin D increased falls and fractures in older women
Authors: K Sanders
Journal: Annals of Internal Medicine (2010)

ACP Journal Club21 September 2010A single, annual, high dose of oral vitamin D increased falls and fractures in older womenSteven R. Cummings, MDSteven R. Cummings, MDCPMC Research Institute and, University of California, San Francisco, San Francisco, California, USA (S.R.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-6-201009210-02003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationSanders KM, Stuart AL, Williamson EJ, et al. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA. 2010;303:1815-22. https://pubmed.ncbi.nlm.nih.gov/20460620Clinical Impact RatingsGIM/FP/GP: Geriatrics: Rheumatology: References1 Byers T. Anticancer vitamins du jour—the ABCED’s so far [Editorial]. Am J Epidemiol. 2010;172:1-3. [PMID: 20562190] Google Scholar2 Avenell A, Gillespie WJ, Gillespie LD, O’Connell D. Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database Syst Rev. 2009;(2):CD000227. [PMID: 19370554] Google Scholar3 DIPART (vitamin D Individual Patient Analysis of Randomized Trials) Group. Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe. BMJ. 2010;340:b5463. [PMID: 20068257] Google Scholar4 Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84:18-28. [PMID: 16825677] Google Scholar5 Dawson-Hughes B, Mithal A, Bonjour JP, et al. IOF position statement: vitamin D recommendations for older adults. Osteoporos Int. 2010;21:1151-4. [PMID: 20422154] Google Scholar6 Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, et al. Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ. 2009;339:b3692. [PMID: 19797342] Google Scholar7 Smith H, Anderson F, Raphael H, et al. Effect of annual intramuscular vitamin D on fracture risk in elderly men and women—a population-based, randomized, double-blind, placebo-controlled trial. Rheumatology (Oxford). 2007;46:1852-7. [PMID: 17998225] Google Scholar8 Tang BM, Eslick GD, Nowson C, Smith C, Bensoussan A. Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet. 2007;370:657-66. [PMID: 17720017] Google Scholar Author, Article, and Disclosure InformationAffiliations: CPMC Research Institute and, University of California, San Francisco, San Francisco, California, USA (S.R.C.)This article was published at Annals.org on 7 September 2010. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 September 2010Volume 153, Issue 6Page: JC3-3KeywordsCalciumCancer preventionFallsHip fracturesOsteoporosisRheumatologySafetyVitamin AVitamin D ePublished: 21 September 2010 Issue Published: 21 September 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...