tbuckley/cabot-search huggingface dataset:
Treatment of Gonorrhea
Authors: WILLIAM M. MCCORMACK
Journal: Annals of Internal Medicine (1979)

Editorials1 May 1979Treatment of GonorrheaWILLIAM M. MCCORMACK, M.D.WILLIAM M. MCCORMACK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-5-845 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe most recent recommendations of the Center for Disease Control for the treatment of infections due to Neisseria gonorrhoeae appear on pages 809-811 of this issue. These recommended treatment schedules replace those issued in 1974 (1) and were drawn up by the Venereal Disease Control Division, Bureau of State Services, after receiving advice from a group of extramural experts. In preparation for this task, members of the Venereal Disease Control Division prepared position papers on various aspects of gonorrhea treatment. These papers will be published separately as a supplement to Sexually Transmitted Diseases.The most noteworthy change in the new...References1. : Gonorrhea—CDC recommended treatment schedules, 1974. Morbid Mortal Weekly Rep 23:341-348, 1974 Google Scholar2. MCCORMACK W and FINLAND M: Drugs five years later: spectinomycin. Ann Intern Med 84:712-716, 1976 LinkGoogle Scholar3. ESCHENBACH D, BUCHANAN T, POLLOCK H, FORSYTH P, ALEXANDER E, LIN J, WANG S, WENTWORTH B, MCCORMACK W, and HOLMES K: Polymicrobial etiology of acute pelvic inflammatory disease. N Engl J Med 293:166-171, 1975 CrossrefMedlineGoogle Scholar4. BERGER R, ALEXANDER E, MONDA G, ANSELL J, MCCORMICK G, and HOLMES K: Chlamydia trachomatis as a cause of acute "idiopathic" epididymitis. N Engl J Med 298:301-304, 1978 CrossrefMedlineGoogle Scholar5. WIESNER P, HANDSFIELD H, and HOLMES K: Low antibiotic resistance of gonococci causing disseminated infection. N Engl J Med 288:1221-1222, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM M. MCCORMACK, M.D.Affiliations: State Laboratory Institute Massachusetts Department of Public Health Channing Laboratory Peter Bent Brigham Hospital Division of Affiliated Hospitals Center Inc. Department of Medicine Harvard Medical School Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNot Quite Filling the Gap: Why the Miscellaneous Expense Allowance for Student-Athletes Leaves the NCAA Still Vulnerable to Antitrust LitigationSexually Transmitted DiseasesGonorrhea and the Story of Resistant Neisseria gonorrhoeaeTreatment of common genital infections in adolescentsEpidemiology and treatment of gonorrhoea caused by penicillinase-producing strains of Neisseria gonorrhoeae in Fukuoka, JapanTreatment of gonococcal proctitisReverse Osmosis Membranes 1 May 1979Volume 90, Issue 5Page: 845-846KeywordsGonorrheaInfectious disease controlNeisseria gonorrhoeaeSexually transmitted diseases ePublished: 1 December 2008 Issue Published: 1 May 1979 PDF downloadLoading ...
Homeobox A9 Transcriptionally Regulates the EphB4 Receptor to Modulate Endothelial Cell Migration and Tube Formation
Authors: Thomas Bruhl, Carmen Urbich, Diana Aicher, Amparo Acker-Palmer, Andreas M. Zeiher, Stefanie Dimmeler
Journal: Circulation Research (2004)

Homeobox genes (Hox) encode for transcription factors, which regulate cell proliferation and migration and play an important role in the development of the cardiovascular system during embryogenesis. In this study, we investigated the role of HoxA9 for endothelial cell migration and angiogenesis in vitro and identified a novel target gene, the EphB4 receptor. Inhibition of HoxA9 expression decreased endothelial cell tube formation and inhibited endothelial cell migration, suggesting that HoxA9 regulates angiogenesis. Because Eph receptor tyrosine kinases importantly contribute to angiogenesis, we examined whether HoxA9 may transcriptionally regulate the expression of EphB4. Downregulation of HoxA9 reduced the expression of EphB4. Chromatin-immunoprecipitation revealed that HoxA9 interacted with the EphB4 promoter, whereas a deletion construct of HoxA9 without DNA-binding motif (Δaa 206-272) did not bind. Consistently, HoxA9 wild-type overexpression activated the EphB4 promoter as determined by reporter gene expression. HoxA9 binds to the EphB4 promoter and stimulates its expression resulting in an increase of endothelial cell migration and tube forming activity. Thus, modulation of EphB4 expression may contribute to the proangiogenic effect of HoxA9 in endothelial cells.
Immune-Complex Disease
Authors: Charles L. Christian
Journal: New England Journal of Medicine (1969)

THE term immune-complex disease describes a state in which circulating antigen–antibody complexes, formed by coexisting immune reactants, induce vascular injury. In this presentation I will review evidence that immune complexes are responsible for the development of glomerulonephritis in systemic lupus erythematosus (SLE), and analyze the variables affecting the pathogenesis of an experimental model (chronic serum sickness) that, in many respects, resembles SLE nephritis.Systemic Lupus ErythematosusClinical FeaturesAt the outset, it is appropriate to comment on the clinical and pathological features of the syndrome as we now recognize them and to compare them with the picture of SLE 20 . . .
Genetic and functional complexity of inherited retinal degeneration
Authors: Stephen P. Daiger, Lori S. Sullivan, Joseph A. Rodriguez
Journal: Behavioral and Brain Sciences (1995)

Abstract Recent findings emphasize the complexity, both genetic and functional, of the manifold genes and mutations causing inherited retinal degeneration in humans. Knowledge of the genetic bases of these diseases can contribute to design of rational therapy, as well as elucidating the function of each gene product in normal visual processes.
Controlled Therapeutic Trials for Malignant Hepatoma: Overlooked Studies
Authors: Geoffrey Falkson
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 October 1988Controlled Therapeutic Trials for Malignant Hepatoma: Overlooked StudiesGeoffrey Falkson, MD, Buks J. Coetzer, MB, ChBGeoffrey Falkson, MDSearch for more papers by this author, Buks J. Coetzer, MB, ChBSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-8-681_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:We read with interest the reports of the Conference of the National Institutes of Health on hepatocellular carcinoma. In the section "Treatment of Hepatocellular Carcinoma," Dr. Lotze refers to the publication by Friedman and coworkers (reference 96) and then states, "The only other controlled, randomized study (97) of treatment for unresectable hepatocellular carcinoma was reported from Hong Kong." This statement is not correct. The first significant publication on controlled, randomized studies in hepatocellular carcinoma, "Malignant Hepatoma: Controlled Therapeutic Trials," was published in the March 1967South African Medical Journal: Dr. Lotze also overlooked five later controlled, randomized...References1. GeddesFalkson EG. Malignant hepatoma in the bantu. Cancer. 1970;25:1271-8. CrossrefMedlineGoogle Scholar2. FalksonMoertelLavinPretoriusCarbone GCPFP. Chemotherapy studies in primary liver cancer. Cancer. 1978;42:2149-56. CrossrefMedlineGoogle Scholar3. FalksonMacIntyreMoertelJohnsonScherman GJCLR. Primary liver cancer: an Eastern Cooperative Oncology Group Trial. Cancer. 1984;54:970-7. CrossrefMedlineGoogle Scholar4. FalksonRyanJohnson GLL A random phase II study of mitoxantrone and cisplatin in patients with hepatocellular carcinoma: an ECOG study. Cancer. 1987;60:2141-5. CrossrefMedlineGoogle Scholar5. FalksonMacIntyreSchutt GJA Neocarzinostatin versus m-AMSA or doxorubicin in hepatocellular carcinoma. J Clin Oncol. 1984;2:581-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Pretoria Pretoria, 0001, Republic of South Africa PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1988Volume 109, Issue 8Page: 681-682KeywordsHepatocellular carcinoma Issue Published: 15 October 1988 PDF downloadLoading ...
388 SPLEEN STIFFNESS CORRELATES WITH PORTAL HYPERTENSION AND INCREASES THE ACCURACY OF DETECTION OF ESOPHAGEAL VARICES IN HCV CIRRHOSIS
Authors: V. Calvaruso, V. Di Marco, F. Bronte, G. Licata, F. Simone, G. Butera, G. Pecoraro, D. Cabibbi, N. Alessi, C. Cammà, A. Craxì
Journal: Journal of Hepatology (2010)
AIDS deaths fall by nearly one half
Authors: S. Gottlieb
Journal: BMJ (1998)

The number of Americans who died of AIDS fell to 16 865 last year, almost half the number in 1996 and well below the 43 000 deaths in the peak year of 1995, according to newly released US government statistics.

It is the second year that AIDS deaths have dropped in the United States, this time nearly twice as fast as in 1996 and enough to push the disease out of the top 10 causes of death in America for the first time since 1990. The increased access to …
Points from Letters: Patients' Demands
Authors: G. B. Stenhouse
Journal: BMJ (1964)

BRTSw=Hcomings of others-presumably they hope their own virtues will show up better by contrast; but, really, 800 purple hearts a day are too much for any of us to swallow, literally or figuratively.No details have been given, so far as I know, of how many were in the family or how long the tablets were supposed to last, or whether the circum- stances justified the prescribing of purple hearts in any quantity.This statement has been so damaging to the profession in lay eyes and so surprising and shocking to the vast majority of doctors in general practice who never prescribe more than two Drinamyl a day-and these with some diffidence-that the Ministry should justify the statement of the official by supply- ing details to the profession by way of Prescribers' Notes or in the B.M.7.
Sexually Transmitted Diseases
Authors: Philip D. Shenefelt
Journal: JAMA (1991)

<i>Sexually Transmitted Diseases</i>is the first volume in the new series<i>Topics in</i><i>Clinical Dermatology</i>. It is intended to be a concise guide to sexually transmitted diseases for clinicians. The text is succinct and adequate in content for its purpose. Readability is about average. A generous number of tables, line drawings, and black-and-white and color photographs accompany the text. Most are of high quality, although some in black and white and a few in color are under- or overexposed. Many of the photographs were supplied by the Institute of Venerology of the Polish Warsaw Medical Academy. The book is well organized in 15 chapters. Each of the first 11 presents a single organism and the spectrum of disease it produces. Furthermore, each chapter has an introduction and sections on epidemiology, etiology, pathology, clinical manifestations in adults, diagnosis and differential diagnosis, treatment, complications, infections in pregnancy, neonates and childhood, treatment of
Community Services for the Mentally Handicapped
Authors: I. Kolvin
Journal: BMJ (1965)

MEDICJOUH 1481 suffering, and premature death.However, the great need in medical education and medical care to-day is for deeds, not words, for experiment and not disputation, and it is greatly to be hoped that Professor McKeown will be able to bring to rapid completion the plans prepared by himself and his colleagues for a balanced teaching hospital in Birmingham.
Current Surgical Management II: A Book of Alternative Viewpoints on Controversial Surgical Problems
Authors: Philip Thorek
Journal: JAMA (1961)

The commonest controversial problems of surgery are discussed in the text by 50 contributors from all over the country, who work in private, university, and Veterans Administration hospitals. Most of them are also "teaching" surgeons with university assignments, who write from both clinical experience and research investigation. In each area, one of the editors elucidates the problem, which is then discussed by two or more, and sometimes as many as four, specialists. Their investigation considers the complications of duodenal ulcer, various types of polyps of the colon, approaches to repair of hiatal hernia, early operation versus intestinal decompression and delayed surgery in small intestinal obstruction, whether to use an abdominal or perineal approach to correct a prolapse of the rectum, the extent to which antibiotics should be used when operating on the intestine, and whether or not to suture the common bile duct. These are only a few of the
Liver Tear: A Previously Unreported Serious Complication of Endoscopic Balloon Dilation for Benign Gastric Outlet Obstruction
Authors: R. S. Date, R. Makar, N. Das, K. J. Panesar
Journal: Endoscopy (2003)

Endoscopic balloon dilation is a useful alternative to surgery for the treatment of gastric outlet obstruction, particularly in patients who are unfit for surgery or do not wish to undergo operation. Perforation is a known complication of endoscopic balloon dilation [1] [2] [3] [4], but associated tearing of the liver has not been previously reported. We present a case of duodenal perforation and liver tear secondary to balloon dilation for acute gastric outlet obstruction.
Two Distinct Steps during Thymocyte Maturation from CD4−CD8− to CD4+CD8+ Distinguished in the Early Growth Response (Egr)-1 Transgenic Mice with a Recombinase-activating Gene–Deficient Background
Authors: Toru Miyazaki
Journal: The Journal of Experimental Medicine (1997)

The early growth response (Egr)-1 is a zinc finger–containing transcription factor belonging to the immediate–early genes. Its expression in CD4/CD8 double negative (DN) immature thymocytes suggests that Egr-1 expression may be involved in early thymocyte development. In transgenic mice overexpressing Egr-1 in a recombinase-activating gene–deficient background, thymocytes bypassed the block at the CD25+CD44− DN stage and matured to the immature CD8 single-positive (ISP) cell stage, but not further to the CD4/CD8 double-positive (DP) cell stage. When these mice were irradiated, thymocytes did develop to the DP stage, suggesting transcriptional induction of additional genes by irradiation that are required to promote thymocyte development from the ISP to the DP stage. These results provide genetic evidence for two distinct steps during early thymocyte development from the CD25+CD44− DN to the DP stage. The first step, from the CD25+CD44− DN to the ISP stage, can be entirely promoted by overexpression of Egr-1.
A vitreoretinal service.
Authors: J. Richardson, C. M. Wood, L. J. Mackay, E. S. Gardner
Journal: BMJ (1989)

Many serious disorders that threaten eyesight can now be treated with vitreoretinal surgery. As there was no regional facility for this treatment a service was developed to provide it. Among the first 100 patients treated over half had diabetic vitreoretinal disease. The remainder had ocular trauma (15), non-diabetic vasculopathy (10), rhegmatogenous retinal detachment (10), and miscellaneous disorders including diagnostic procedures (14). Sight was improved in most cases, 27 diabetic and 21 non-diabetic patients regaining navigating vision. Few patients were made worse: one only of the 49 non-diabetic patients and 12 of the 51 diabetic patients, and none whose vision was better than the ability to count fingers before operation. The many indications for this procedure, the size of the population that could benefit (an estimated minimum of 3800 operations per year in the United Kingdom in patients with diabetes alone), and the great potential benefit of the procedure all suggest the need for regional services. These would be cost effective in preventing blindness.
DR (Ia-like) antigens on human melanoma cells. Serological detection and immunochemical characterization.
Authors: B S Wilson, F Indiveri, M A Pellegrino, S Ferrone
Journal: The Journal of Experimental Medicine (1979)

11 cultured human melanoma cell lines were tested for the expression of DR antigens by using specific allo- and xenoantisera in an indirect rosette microassay. Four of these melanoma cell lines expressed DR antigens, but in lower amounts than expressed on cultured human B-lymphoid cells. Rabbits injected with the DR-positive melanoma cells produced antibodies that were serologically and immunochemically reactive with B-cell-derived DR antigens. Immunochemical studies indicate that melanoma cell-derived DR antigens have a two-chain structure with 34,000 and 27,000 mol wt components. The melanoma cell-derived DR beta-chain at 27,000 mol wt is slightly smaller than that of the Victor cell DR beta-chain whose mol wt is 29,000.
Bodily Response to Infectious Agents
Authors: William A. Altemeier
Journal: JAMA (1967)

Infection is one of the salient features of human life, and many important infections are of surgical significance. The development of an understanding of this aspect of medicine is, therefore, an essential part of the education of the medical student. As a matter of fact, this presentation is the result of my sustained interest in this subject which began 35 years ago as a medical student. The ubiquity of infectious agents in man's environment, their propensity for invading the physiologic interior of the body, their potential for producing significant effects on the various bodily functions, their remarkable adaptability to circumstance and newer forms of treatment as introduced, and the very necessity for excluding their presence or controlling their growth to permit surgical treatment and wound healing with acceptable standards, all emphasize the significance of infections in surgical practice and the importance of related education. The remarkable advances in surgery during
Modeling Alveolar Soft Part Sarcomagenesis in the Mouse: A Role for Lactate in the Tumor Microenvironment
Authors: Matthew L. Goodwin, Huifeng Jin, Krystal Straessler, Kyllie Smith-Fry, Ju-Fen Zhu, Michael J. Monument, Allie Grossmann, R. Lor Randall, Mario R. Capecchi, Kevin B. Jones
Journal: Cancer Cell (2014)
Abstract B47: microRNA-181a plays a critical role in ovarian cancer progression through the regulation of epithelial-mesenchymal transition
Authors: Aditya Parikh, Christine Lee, Peronne Joseph, Sergio Marchini, Alessia Baccarini, Valentin Kolev, Chiara Romualdi, Robert Fruscio, Hardik Shah, Wang Feng, Gavriel Mullokandov, David Fishman, Maurizio D'Incalci, Jamal Rahaman, Tamara Kalir, Raymond Redline, Brian D. Brown, Goutham Narla, Analisa DiFeo
Journal: Clinical Cancer Research (2013)

Abstract Ovarian cancer is the most lethal gynecological cancer primarily due to advanced stage of disease at diagnosis. Effective therapeutic targets and prognostic biomarkers are still lacking due to insufficient knowledge of the pathways that regulate ovarian cancer progression. Here, we identify miR-181a as a mediator of disease dissemination through the induction of EMT and direct activation of the TGF-β signaling pathway via repression of its functional target, Smad7. High expression of miR-181a and phospho-Smad2 were associated with poor patient outcome and were enriched in recurrent compared to matched-primary tumors. Ectopic expression of miR-181a resulted in increased cellular survival, migration, drug resistance, and in vivo tumor burden, and dissemination. Conversely, targeting this miRNA using a decoy vector resulted in significant decreases in cell survival, migration, and MET in ovarian cancer cell lines. Combined, our findings identify miR-181a as a novel modulator of ovarian cancer dissemination through the induction of EMT and highlight its role as a potential biomarker and therapeutic target for aggressive late-stage ovarian cancer. Citation Format: Aditya Parikh, Christine Lee, Peronne Joseph, Sergio Marchini, Alessia Baccarini, Valentin Kolev, Chiara Romualdi, Robert Fruscio, Hardik Shah, Wang Feng, Gavriel Mullokandov, David Fishman, Maurizio D'Incalci, Jamal Rahaman, Tamara Kalir, Raymond Redline, Brian D. Brown, Goutham Narla, Analisa DiFeo. microRNA-181a plays a critical role in ovarian cancer progression through the regulation of epithelial-mesenchymal transition. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr B47.
Phosphorylation of ATR-Interacting Protein on Ser239 Mediates an Interaction with Breast-Ovarian Cancer Susceptibility 1 and Checkpoint Function
Authors: Monica Venere, Andrew Snyder, Omar Zgheib, Thanos D. Halazonetis
Journal: Cancer Research (2007)

Abstract The signaling of DNA damage and replication stress involves a multitude of proteins, including the kinases ataxia-telangiectasia mutated (ATM) and ATM and Rad3-related (ATR), and proteins with BRCA1 COOH-terminal (BRCT) domains. The BRCT domain–containing proteins facilitate the phosphorylation of ATM/ATR substrates and can be coimmunoprecipitated with ATM or ATR. However, their mode of interaction with the ATM/ATR kinases remains elusive. Here, we show that breast-ovarian cancer susceptibility 1 (BRCA1) interacts directly with ATR-interacting protein (ATRIP), an obligate partner of ATR. The interaction involves the BRCT domains of BRCA1 and Ser239 of ATRIP, a residue that is phosphorylated in both irradiated and nonirradiated cells. Consistent with a role of BRCA1 in ATR signaling, substitution of Ser239 of ATRIP with Ala leads to a G2-M checkpoint defect. We propose that a direct physical interaction between BRCA1 and ATRIP is required for the checkpoint function of ATR. [Cancer Res 2007;67(13):6100–5]
Penicillin-Streptomycin Treatment of Enterococcal Endocarditis
Authors: Ernest Jawetz, Minetta Sonne
Journal: New England Journal of Medicine (1966)

ENTEROCOCCI (Streptococcus faecalis) are generally not highly sensitive to penicillin, and penicillin alone can rarely kill enterococcal populations. Although enterococci are generally resistant to streptomycin, the addition of that drug to penicillin frequently enhances its bactericidal activity in vitro. The combined antibacterial action of the two agents on enterococci is perhaps the most widely accepted example of antibiotic synergism. Their simultaneous administration has resulted in bacteriologic cures of enterococcal endocarditis in a large majority of cases.1 2 3 4 In our laboratory, studies on combined antibiotic effects have been pursued intermittently for the past fifteen years. Several questions have been raised. First of . . .
Who Should Do the Coding?
Authors: Joseph S. Solomkin
Journal: JAMA (1986)

<h3>To the Editor.—</h3> The recently published article, "Physician and Coding Errors in Patient Records,"<sup>1</sup>is an important collection of information regarding interaction between physicians and an increasingly complex set of administrative responsibilities for medical records. I take serious issue, however, with underlying assumptions that appear to have been made regarding responsibilities for completion of patient record coding and assumptions made regarding diagnostic classifications. The assumption is made that physicians are responsible for correctly reporting all procedures performed on a patient, ranging from major operative procedures performed in the operating room with the patient under general anesthesia, through radionuclide scans. The suggestion is made that physician "failure" to report various procedures results in loss of revenue to hospitals. I am unaware of any prior discussion regarding the appropriate allocation of responsibility for chart review and recording of various procedures. I have some difficulty understanding why such clear-cut administrative functions are