tbuckley/cabot-search huggingface dataset:
Intracoronary Angiotensin II Potentiates Coronary Sympathetic Vasoconstriction in Humans
Authors: Antonio Saino, Guido Pomidossi, Rodolfo Perondi, Romano Valentini, Alberto Rimini, Lucia Di Francesco, Giuseppe Mancia
Journal: Circulation (1997)

Background In humans with coronary artery disease, ACE inhibition attenuates coronary sympathetic vasoconstriction. Whether this is due to removal of angiotensin (Ang) II production or to a reduced bradykinin breakdown, however, is unknown. Methods and Results In eight normotensive patients with angiographic evidence of mild left coronary artery lesions (≤50%), mean arterial pressure (MAP, intra-arterial catheter), heart rate (HR, ECG lead), coronary sinus blood flow (CBF, thermodilution method), and coronary vascular resistance (CVR, ratio between MAP and CBF) were measured before and during a 15-minute left intracoronary infusion of Ang II at a dose that had no direct coronary or systemic vasomotor effects. The same measurements were made before and during a 15-minute infusion of saline. A 2-minute cold pressor test (CPT) and a 45-second diving were performed at the end of either infusion period. These maneuvers were used because their coronary vasomotor effects are abolished by phentolamine and thus depend on sympathetic activation. During saline infusion, both CPT and diving caused a marked increase in MAP. HR increased with CPT and fell with diving. CBF increased in parallel to the MAP increase, with little change in CVR. The MAP and HR responses were similar during Ang II infusion, which, however, caused either no change or a reduction in CBF with a consequent marked increase in CVR with both CPT and diving. In four additional patients, the diameter of the stenotic vessels remained unchanged during the CPT performed under saline and Ang II infusion. Conclusions Ang II markedly enhances sympathetic influences on coronary circulation in humans, presumably by acting at the arteriolar level. This may explain the blunting effect of ACE inhibition on sympathetic coronary vasoconstriction in patients with coronary artery disease.
AN UNUSUAL RING-SHAPED SYPHILITIC ERUPTION IN AN INFANT; WITH PHOTOGRAPHS
Authors: J. E. M. WIGLEY
Journal: British Journal of Dermatology (1923)

Journal Article AN UNUSUAL RING‐SHAPED SYPHILITIC ERUPTION IN AN INFANT; WITH PHOTOGRAPHS Get access J. E. M. WIGLEY, M.B., M.R.C.P. J. E. M. WIGLEY, M.B., M.R.C.P. Physician to the Skin Department, Paddington Green Children's Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 35, Issue 7, 1 July 1923, Pages 281–282, https://doi.org/10.1111/j.1365-2133.1923.tb09117.x Published: 01 July 1923
A METHOD OF TREATING FRACTURES OF THE CLAVICLE WITH DISPLACEMENT
Authors: G. W. Milroy
Journal: BMJ (1928)

MIXED TUMOUR OF? NASOPHARYNX.[ THE BRITINA left costal margin.In the course of four or five minutes -voluntary respiration was again established, the pupils con- tracted, and consciousness was regained.No residual effects w-ere noted.The examination of the electro-cardiogram during this period showed the normal cardiogram to be replaced by one in which the rate of the heart was reduced to one-half.No changes were to be seen in the P.Q.R. complex at the time of this clhange in the frequency.Each wave possessed its normal order, time relationship, and character.After tllis bradyeardia had lasted for ten seconds it was replaced by a series of small waves, which were suggestive of vibration of the string.There is no evidence in, the cardiogramii that the ventricle was-beating during this perio(l.At the end of the curve, whien the subject was removed fromii the electrodes, these small fibrillaiy waves were less fiiequent but of greater amplitude.There was as yet no evidence of the R wave of ventricular contraction.Tlle tracing was that of a prolonged sino-auricular block. COMMENT.From these few observations it is not possible to reacll any conclusions as to the effect of calciunm upon the normal electro-cardiogram..Whether the effects noted in the second experiment are evidences of vagal stimulation or a direct action upon the genetic nervous systenm of the heart independently of any extrinsic nervous supply it is impossible to state.The nature of the results obtained rendered it inadvisable to repeat the experiment following atropinization.The disturbances of conduction noted are somewhat in accordance with those obtained by Walters and Bowler in the dog.I simply desire to call attention to the occurrence of cardiac disturbances of conductionl as a result of intra- venous calcium administrationl in a dosage that has been commonly used.SUMMARY.The intravenous use of 4 c.cm. of a 10 per cent.solution of calcium chloride is dangerous.The electro-cardiogram Slhows what we believe to be a sino-auricular heart-block.To my chief, Professor J. W. Crane, and to Drs.
640 INTRAVENOUS SILIBININ AS “RESCUE TREATMENT” FOR ON TREATMENT NONRESPONDERS TO FULL DOSE OF PEGINTERFERON/RIBAVIRIN COMBINATION THERAPY
Authors: K. Rutter, S. Beinhardt, H. Kerschner, T.M. Scherzer, H. Hofer, T. Popow-Kraupp, P. Steindl-Munda, P. Ferenci
Journal: Journal of Hepatology (2009)
Mapping of activation changes within the acutely ischaemic canine specialised conduction system
Authors: C. LYONS, P. SCHROEDER
Journal: Cardiovascular Research (1985)

Ligation of the anterior septal artery was used to produce acute ischaemia of the specialised conduction system in ten dogs. Activation times at selected positions within the specialised conduction system were recorded. Marked delays of activation occurred between several discrete anatomic sites within die specialised conduction system. This study demonstrates that extremely slow conduction is common in localised areas of the acutely ischaemic infra-nodal conduction system. Heterogeneity of myocardial activation secondary to changes of speed of the conduction during acute septal ischaemia is postulated as a mechanism facilitating the occurrence of malignant ventricular arrhythmias.
Different mechanisms decrease hepatic collagen and albumin production in fasted rats
Authors: Mario Chojkier, Michael Flaherty, Beverly Peterkofsky, Gopa H. Majmudar, Robert G. Spanheimer, David A. Brenner
Journal: Hepatology (1988)

Weight loss is correlated with a specific decrease in collagen synthesis in extrahepatic tissues, mainly through modulation of mRNA levels. Here, we investigated the response to weight loss in the rat liver. Male rats were either fed ad libitum or fasted for 92 hr; fasted animals lost ∼20% of their initial body weight. Following i.p. injection of [5-3H]proline, hepatic collagen was extracted and de novo collagen production was measured. There was a decrease in the specific radioactivities of purified hepatic collagen (−75%) and albumin (−70%) relative to total hepatic protein, indicating that production of both of these proteins was specifically decreased. In fasted animals, the absolute hepatic collagen production was markedly decreased (−60%), while changes in absolute hepatic protein production were small (−15%). Using hybridization with specific DNA probes, we found that fasting causes about a 70% decrease in albumin mRNA, but the quantities of hepatic procollagen α1(I) and α2(I) mRNAs were unchanged. These results are consistent with regulation of albumin production during fasting by modulation of mRNA levels. The inhibition of hepatic collagen production in fasted animals, however, appears to be modulated at a posttranscriptional level or may result from increased degradation. This response differs from the pretranslational regulation of collagen synthesis in extrahepatic tissues during fasting. Furthermore, our results suggest that decreased body weight could be a potentially complicating variable in studies of collagen metabolism and fibrogenesis in the liver.
Clopidogrel bisulphate-induced photosensitive lichenoid eruption: first report
Authors: S. Dogra, A.J. Kanwar
Journal: British Journal of Dermatology (2003)

Sir, Clopidogrel bisulphate is a novel thienopyridine derivative, chemically related to ticlopidine, and is used in patients at risk of thromboembolic disorders such as myocardial infarction, peripheral arterial disease and stroke. It acts primarily as an inhibitor of the adenosine diphosphate (ADP) pathway of platelet aggregation.1 We report a case of photosensitive lichenoid eruption to clopidogrel. To the best of our knowledge, this has not been reported previously. A 58‐year‐old woman had a thromboembolic attack (stroke) 14 months previously, following which she was prescribed oral clopidogrel 75 mg daily and aspirin 75 mg daily. Within a month of starting these medications, she developed erythematous minimally itchy skin lesions over the face, neck and forearms. The patient on her own attributed the eruption to clopidogrel, which she therefore stopped, whereas aspirin was continued. This resulted in resolution of the skin lesions within 4 weeks. On the advice of her physician clopidogrel was restarted. Again, there was recurrence of similar lesions within a week. Following this, the patient stopped clopidogrel and the lesions regressed almost completely. About 3 months prior to presentation, the patient again took a tablet of clopidogrel on her own and noticed recurrence of lesions within a week. At this recurrence, she was referred to us.
URTICARIA CAUSED BY COLD
Authors: Alfred W. Dubbs
Journal: JAMA (1935)

In looking over the literature for methods of treatment and data on which to base a prognosis, I found that but few cases of urticaria due to cold have been reported in the English literature. Bray<sup>1</sup>found only thirty-seven cases reported in all the literature before 1931, the first of these being mentioned by Béhier<sup>2</sup>in discussing a paper on urticaria. It is of interest to note at this point that one of these thirty-seven, a case reported by Duke,<sup>3</sup>is not an urticaria due to cold but one due to light. Since the appearance of Bray's article I have been able to find but one more case reported in the English literature, that by Weiss,<sup>4</sup>although a few have appeared in other than English publications during this time. In view of the apparent rarity of this condition I thought that it might not be amiss to add my case to the literature.
Testing dialysing fluids.
Authors: W. H. Lyle
Journal: BMJ (1969)

Disappearance Of L-Dopa SIR,-Since your leading article (24 June 1967, p. 783) on the successful use of dopa in the treatment of Parkinsonism, as pre- viously reported in the New England fournal of Medicine,' there have been other reports of the efficiency of this mode of treatment.It has been glowingly reported by Alistair Cooke in the Guardian (3 February 1969) and splashed across the pages of Life maga- zine (11 October 1968).A controlled trial has recently been done in this country in post- encephalitic Parkinsonism and confirms the usefulness of the drug.' Unfortunately this drug has always been very difficult to obtain in this country, and in the last few months it has virtually dis- appeared.This is a disgraceful situation that is hard for a doctor to understand, but it seems to be based on the apathy of some drug houses and curious take-over activities behind the scenes, somewhat reminiscent of the Third Man, by others.Is it not time that the British pharmaceutical industry was mobilized to serve a pressing need ?-I am, etc.,
Retrospective study on fluticasone propionate aqueous nasal spray efficacy in patients with allergic rhinitis: evaluation of clinical and laboratory parameters
Authors: M. Ventura, T. Piccinni, M. G. Matino, G. Giuliano, R. Di Corato, P. Di Napoli, A. Tursi
Journal: Allergy (2001)

In allergic rhinitis, allergenic stimulation causes the release of various mediators that induce symptoms and the development of chronic inflammation, which, in turn, is caused by cells involved in the late phase of inflammation, such as eosinophils. The eosinophils also cause damage at the mucosal level through the secretion of eosinophil cationic protein and other preformed factors contained in their granules. The objective was to verify the efficacy of fluticasone propionate aqueous nasal spray in patients with allergic rhinitis; in a retrospective study, we have evaluated mediators of inflammation, making correlations with the clinical symptoms score during and outside the pollen season.Forty patients with allergic rhinitis and 15 normal controls were included in our study. Eosinophil cationic protein, eosinophil chemotactic activity, and blood and nasal lavage eosinophil count were evaluated as laboratory parameters.We found a significant increase in nasal lavage levels of eosinophil cationic protein in allergic patients, and this was strictly correlated with the clinical symptoms score. No differences were found in the eosinophil count of allergic patients and in the serum eosinophil cationic protein of patients sensitized to seasonal allergens in comparison with normal subjects. By contrast, an increase in serum eosinophil cationic protein level was found in patients sensitized to perennial allergens. After topical administration of fluticasone propionate aqueous nasal spray, a reduction in nasal lavage eosinophil cationic protein secretion was obtained with a reduction of eosinophil chemotactic activity at the local level. This reduction correlated with an improvement of clinical symptoms.The clinical improvement and reduction in nasal lavage eosinophil cationic protein and eosinophil chemotactic activity after administration of fluticasone propionate aqueous nasal spray further confirms the role of this treatment in allergic rhinitis.
HIRSCHSPRUNG'S DISEASE STUDIED WITH MONOCLONAL ANTINEUROFILAMENT ANTIBODIES ON TISSUE SECTIONS
Authors: Paul Klück, GoosN.P. Van Muijen, ArthurW.M. Van Der Kamp, Dick Tibboel, SvenO. Warnaar, WopkeA. Van Hoorn, JanC. Molenaar
Journal: The Lancet (1984)
Impact of disablement due to rheumatic disorders in a British population: estimates of severity and prevalence from the Calderdale Rheumatic Disablement Survey.
Authors: E M Badley, A Tennant
Journal: Annals of the Rheumatic Diseases (1993)

A survey of rheumatic disablement in the population has enabled the comparative impact of self reported causes of disability to be studied. One in three households in Calderdale, West Yorkshire, United Kingdom was screened in 1986 with a postal questionnaire (87% response rate), followed by in depth interviews with a sample of subjects reporting disability in conjunction with a rheumatic disorder (608 interviews). Severity of disablement was assessed using the physical independence handicap classification. The estimated prevalence of disability in conjunction with reported rheumatic disorders is 82/1000 population aged at least 16 years (95% confidence interval (CI) 77 to 87). Arthritis (mainly osteoarthritis) is the most commonly reported cause (47/1000 population; 95% CI 43 to 51), followed by back or neck disorders (25/1000; 95% CI 23 to 28), soft tissue disorders (18/1000; 95% CI 15 to 20), and rheumatoid arthritis (RA) (4/1000; 95% CI 3 to 5). A total of 30% reported more than one category of rheumatic disorder (mean number 1.3) and 63% reported non-rheumatic comorbidity. Current joint symptoms were reported by 98%, current antirheumatic drugs (including analgesics) by 70%, and severe pain by 62%. Overall 82% of subjects had seen their general practitioner in the past year, and 71% reported having attended an outpatient clinic; 26% reported current outpatient clinic attendance, and 15% a hospital inpatient stay during the previous year. Forty six per cent reported some dependence, with 12% reporting being dependent on a daily basis. Rheumatoid arthritis was the most disabling disorder with 73% dependent. Taking into account prevalence, osteoarthritis and back disorders are the most, and RA the least, common causes of dependence and incapacitating pain in the population. This challenges stereotypes and raises questions about the organisation and priorities for specialist services and for research.
Changing face of HPV related cancer in the UK
Authors: A. G. Schache, R. Simcock, D. C. Gilbert, R. J. Shaw
Journal: BMJ (2011)

As the UK nears a decision on continuation of the national human papillomavirus (HPV) vaccination programme, Jit and colleagues’ economic evaluation of the available vaccines makes compelling reading.1

When developing arguments for cost effectiveness of the bivalent and quadrivalent vaccines, the analysis bears heavily on available data for cervical cancer, …
An Iron-Containing Dodecameric Heptosyltransferase Family Modifies Bacterial Autotransporters in Pathogenesis
Authors: Qiuhe Lu, Qing Yao, Yue Xu, Lin Li, Shan Li, Yanhua Liu, Wenqing Gao, Miao Niu, Michal Sharon, Gili Ben-Nissan, Alla Zamyatina, Xiaoyun Liu, She Chen, Feng Shao
Journal: Cell Host & Microbe (2014)
Primary care in the accident and emergency department: II. comparison of general practitioners and hospital doctors
Authors: J. Dale, J. Green, F. Reid, E. Glucksman, R. Higgs
Journal: BMJ (1995)

<h3>Abstract</h3> <b>Objective</b>:To compare the process and outcome of "primary care" consultations undertaken by senior house officers, registrars, and general practitioners in an accident and emergency department. <b>Design</b>:Prospective, controlled intervention study. <b>Setting</b>:A busy, inner city accident and emergency department in south London. <b>Subjects</b>:Patients treated during a stratified random sample of 419 three hour sessions between June 1989 and May 1990 assessed at nurse triage as presenting with problems that could be treated in a primary care setting. 1702 of these patients were treated by sessionally employed local general practitioners, 2382 by senior house officers, and 557 by registrars. <b>Main outcome measures</b>:Process variables: laboratory and radiographic investigations, prescriptions, and referrals; outcome variables: results of investigations. <b>Results</b>:Primary care consultations made by accident and emergency medical staff resulted in greater utilisation of investigative, outpatient, and specialist services than those made by general practitioners. For example, the odds ratios for patients receiving radiography were 2.78 (95% confidence interval 2.32 to 3.34) for senior house officer v general practitioner consultations and 2.37 (1.84 to 3.06) for registrars v general practitioners. For referral to hospital specialist on call teams or outpatient departments v discharge to the community the odds ratios were 2.88 (2.39 to 3.47) for senior house officers v general practitioners and 2.57 (1.98 to 3.35) for registrars v general practitioners. <b>Conclusion</b>:Employing general practitioners in accident and emergency departments to manage patients with primary care needs seems to result in reduced rates of investigations, prescriptions, and referrals. This suggests important benefits in terms of resource utilisation, but the impact on patient outcome and satisfaction needs to be considered further.
Abstract 5117: Cytotoxic effects of hypericum extracts on breast and colorectal tumors
Authors: Carla Gibbs, Johnette S. Duggans, Erin Malone, Elbert L. Myles
Journal: Cancer Research (2014)

Abstract The risk of acquiring certain types of cancers has many causes which include age, environment and genetics. There have been advances in the primary treatment options available, which include surgery, radiation therapy, and chemotherapy. However, the survival prognosis for many cancer patients remains low. Cancer treatments may involve chemotherapy, which often cause harsh side effects. The Plant kingdom may provide alternative therapy that may have less side effects and possibly more effective. Hypericum perforatum possesses hypericin, which has been been shown to have antitumor effects with invitro studies on specific cell lines. In other Hypericum species, hypericin makes up a smaller percentage of the extract. However, these species contain other phytochemical compounds that may also exert an antitumor effect. The objective of the present study was to assess the cytotoxic potential of H. perforatum cv. topas, H. olympicum, and H. calycinum on breast and colorectal adenocarcinoma cell lines. MCF7, SW480, and SW620 cells were treated with varying concentrations dosages of methanolic crude extracts from the plant species. Cytotoxicity was determine by measuring the reduction of Alamar Blue after a 24 hour exposure period of 10,000 cells in 96 well fluorescent plates. The reduction was determine using the Molecular Devices fluorescent spectrophotometer. At the lowest comparable concentrations, H. perforatum cv. topas had a greater reduction in tumor growth than MCF7 and SW40 cells lines. Whereas, H. olympicum demonstrated a greater decrease in SW620 cell growth at the lowest comparable concentration. These results suggest a difference in the phytochemical composition of these plants, which should be evaluated in order to determine what metabolite(s) are having the antitumor effect and their target. Citation Format: Carla Gibbs, Johnette S. Duggans, Erin Malone, Elbert L. Myles. Cytotoxic effects of hypericum extracts on breast and colorectal tumors. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5117. doi:10.1158/1538-7445.AM2014-5117
Prostacyclin Reversal of Lethal Endotoxemia in Dogs
Authors: Michael M. Krausz, Takayoshi Utsunomiya, Giora Feuerstein, John H. N. Wolfe, David Shepro, Herbert B. Hechtman
Journal: Journal of Clinical Investigation (1981)

Severe endotoxemia, a condition where microembolization and intravascular coagulation are thought to play important roles, was treated experimentally with prostacyclin (PGI2). In a study of 24 dogs, 8 control animals injected with 1.75 mg·kg−1 of endotoxin died within 24 h. Six animals given intravenous aspirin 100 mg/kg, 30 min after endotoxin died. 9 of 10 dogs infused with 100 ng PGI2·kg−1·min−1 for 3 h, given 30 min after the injection of endotoxin survived 24 h (P < 0.025). Injection of endotoxin resulted in a: (a) maximal 62% fall in mean arterial pressure (P < 0.001); (b) transient doubling of mean pulmonary arterial pressure (P < 0.001); (c) initial 70% drop in cardiac index (P < 0.001); (d) decline in blood platelets from 213,700 to 13,700/mm3 (P < 0.001), and leukocytes from 7,719 to < 750/mm3 (P < 0.001); (e) depressed urine output (P < 0.001); (f) 34% decrease in blood fibrinogen (P < 0.01) and an increase in fibrin degradation products > 50 μg/ml (P < 0.001); (g) fivefold increase in circulating cathepsin D titer (P < 0.005) and (h) increase in blood norepinephrine (P < 0.005), dopamine (P < 0.005), and epinephrine (P < 0.001). Aspirin treatment led to an increase in mean arterial pressure (P < 0.001) and mean pulmonary arterial pressure (P < 0.005), but cardiac index, urine flow, platelets, leukocytes, fibrin degradation products, and cathepsin D levels remained similar to untreated controls. After infusion of PGI2 there was a: (a) prompt increase of cardiac index to base-line levels; (b) late increase in mean arterial pressure (P < 0.005) after the discontinuation of PGI2 treatment (c) restoration of urine output; (d) increase in circulating platelets to levels still below base line but above untreated control animals (P < 0.05); (e) no effect on circulating leukocyte levels; (f) fall in fibrin degradation products to 11.2 μg/ml (P < 0.05); (g) decline in cathepsin D levels to values 60% lower than the untreated controls (P < 0.025); and (h) reduction in plasma norepinephrine levels to base line at 4 h (P < 0.005). Although the mode of PGI2 action is not clear, it is effective in the treatment of experimental endotoxemia.