tbuckley/cabot-search huggingface dataset:
Synthesis of lipoxygenase and epoxygenase products of arachidonic acid by normal and stenosed canine coronary arteries.
Authors: M Rosolowsky, J R Falck, J T Willerson, W B Campbell
Journal: Circulation Research (1990)

Coronary vascular injury promotes blood cell-vessel wall interactions that influence arachidonic acid metabolism and coronary blood flow patterns. Since lipoxygenase and cytochrome P-450 epoxygenase metabolites of arachidonic acid are synthesized by vascular and inflammatory cells and have a variety of important biological actions, we investigated the metabolism of arachidonic acid by these pathways in normal and stenosed, endothelially injured canine coronary arteries. We found and confirmed by gas chromatography/mass spectrometry that primarily 12- and 15-hydroxyeicosatetraenoic acids (HETEs) are synthesized by both coronary artery segments. Lesser amounts of 11-, 9-, 8-, and 5-HETEs are also produced. 15-Ketoeicosatetraenoic acid is also synthesized. The synthesis of 14C-HETEs is fivefold to 10-fold greater by the stenosed than the normal coronary artery. Specific radioimmunoassays indicated that the stenosed coronary artery synthesized 93 +/- 14 and 1,102 +/- 154 ng/g of tissue of 15- and 12-HETE, respectively, while the normal coronary artery produced 17 +/- 3 and 162 +/- 68 ng/g of tissue of 15- and 12-HETE, respectively. Products comigrating with 14,15-; 11,12-; 8,9-; and 5,6-epoxyeicosatrienoic acids (EETs) and the corresponding dihydroxyeicosatrienoic acids (DHETs) were detected predominantly in stenosed coronary arteries by high-pressure liquid chromatography. The structures of the EETs were confirmed by GC/MS. The EETs and prostaglandin I2 produced endothelium-independent, concentration-related relaxations of dog coronary artery rings. These data indicate that normal and stenotic coronary arteries metabolize arachidonic acid to HETEs, DHETs, and EETs along with prostaglandins; however, the synthesis of these metabolites is greater in the stenosed, endothelially injured vessel. The EETs may be synthesized during the development of cyclic flow variations and counteract the vasoconstrictor effects of thromboxane A2.
Eröffnungs-Ansprache des Kongress-Präsidenten
Authors: M. Boss
Journal: Psychotherapy and Psychosomatics (1954)

Research Articles| January 20 2010 Eröffnungs-Ansprache des Kongress-Präsidenten Subject Area: Psychiatry and Psychology M. Boss M. Boss Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1954) 2 (3-4): 205–209. https://doi.org/10.1159/000278430 Article history Published Online: January 20 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation M. Boss; Eröffnungs-Ansprache des Kongress-Präsidenten. Acta Psychotherapeutica et Psychosomatica 31 December 1954; 2 (3-4): 205–209. https://doi.org/10.1159/000278430 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1954Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Vasomotor Responses to Exercise in the Extremities of Subjects with Vascular Disease
Authors: W. REDISCH, K. DE CRINIS, A. ANTONIO, A. BOGDANOVITZ, J. M. STEELE, Gordon Gilbert, Raleigh Wheeler
Journal: Circulation (1959)

Response of peripheral blood flow was studied in subjects of various age groups with and without vascular disease. Under constant environmental conditions, the skin-muscle distribution of total flow to the lower extremity showed the following trend. In young healthy adults the muscles get a somewhat higher share; in elderly persons without vascular disease the distribution is about equal; in patients with nongangrenous obliterative arteriosclerosis the skin is favored over the muscle. Exercise increases total flow in all groups, but does not alter the distribution. Sympathectomy does not seem to influence response to exercise.
Effects of Methionine-Induced Hyperhomocysteinemia on Endothelium-Dependent Vasodilation and Oxidative Status in Healthy Adults
Authors: Chia-Lun Chao, Tsung-Li Kuo, Yuan-Teh Lee
Journal: Circulation (2000)

Background —Homocysteine-mediated endothelial dysfunction has been proposed to occur via oxidative stress mechanisms in humans. However, there is controversy regarding the effects of homocysteine on endothelial function and oxidative status, which may in part result from age discrepancy across the studies. The present study was designed to investigate the aging effect on the relationship between endothelium-dependent vasodilation and oxidative status in methionine-induced hyperhomocysteinemia. Methods and Results —Plasma homocysteine, phosphatidylcholine hydroperoxide (PCOOH), P-selectin levels, and brachial artery flow-mediated vasodilation were measured at baseline and 4 hours after an oral methionine load (0.1 g/kg) in 15 younger (21 to 40 years) and 15 older (55 to 70 years) healthy adults. Homocysteine increased from 7.3±1.3 μmol/L at baseline to 22.7±5.2 μmol/L at 4 hours in younger ( P &lt;0.001) and from 7.4±1.4 to 24.3±4.5 μmol/L in older adults ( P &lt;0.001). PCOOH levels were not significantly different between baseline and 4 hours in both groups ( P =0.10 in young; P =0.14 in old). P-selectin, which is expected to increase during oxidative stress, was not changed in older ( P =0.08) but decreased in younger adults ( P =0.037) at 4 hours. Flow-mediated vasodilation was preserved from 13.1±2.1% at baseline to 13.5±2.8% at 4 hours in younger ( P =0.49) and decreased from 12.8±2.4% to 8.5±2.8% in older adults ( P &lt;0.001). Conclusions —The present study demonstrates that endothelial dysfunction caused by methionine-induced hyperhomocysteinemia is age-related and is mediated through impaired nitric oxide activity without change of oxidative status. Our data do not support previous hypotheses that endothelial damage by homocysteine is via oxidative stress mechanism in humans.
CDK Inhibitor p18INK4c Is Required for the Generation of Functional Plasma Cells
Authors: Michelle R. Tourigny, Josie Ursini-Siegel, Hayyoung Lee, Kai-Michael Toellner, Adam F. Cunningham, David S. Franklin, Scott Ely, Meihong Chen, Xiao-Feng Qin, Yue Xiong, Ian C.M. MacLennan, Selina Chen-Kiang
Journal: Immunity (2002)
Non-Hodgkin's Lymphoma: Possible Role of Hepatitis C Virus
Authors: Clodoveo Ferri
Journal: JAMA (1994)

<h3>To the Editor.</h3> —A number of reports have suggested a role for hepatitis C virus (HCV) in a variety of hepatic and extrahepatic disorders (ie, chronic hepatitis, autoimmune hepatitis, porphyria cutanea tarda, Waldenstrom's macroglobulinemia, and mixed cryoglobulinemia).<sup>1</sup>This latter condition is a "benign" lymphoproliferative disorder that in some subjects can switch over to a malignant B-cell non-Hodgkin's lymphoma (NHL).<sup>1</sup>Moreover, the demonstration of the HCV lymphotropism<sup>2</sup>suggested a pathogenetic role for this virus in B-cell expansion underlying some lymphoproliferative disorders. We investigated the prevalence of HCV infection in 24 unselected patients with B-cell NHL (14 men, 10 women; mean±SD age [range], 61±10 years [35 to 74 years]). Diagnosis of B-cell NHL was done by lymph node biopsy specimen evaluated according to the Working Formulation classification<sup>3</sup>and by immunophenotypic analysis for surface T- and B-lymphocyte markers. All patients were Italian-born heterosexuals and had no history of drug
NEJM sees promise in polypill for low and middle income countries
Authors: Janice Hopkins Tanne
Journal: BMJ (2007)

A “perspectives” commentary in the New England Journal of Medicine by a leading Indian cardiologist says that a “polypill” to combat heart disease “would be quite cost-effective in reducing the burden of cardiovascular disease even in low-income and middle-income countries” ( New England Journal of Medicine 2007;356:3). 

The polypill, a combination of a statin, aspirin, drugs to lower blood pressure, and folic acid, was first proposed by Nicholas Wald and M R Law of the Wolfson Institute of Preventive Medicine, Barts, and Queen Mary's School of Medicine and Dentistry at …
Chronic fatigue syndrome and fibromyalgia
Authors: D O Ho-Yen
Journal: BMJ (1994)

reviews are simply uninformed, for there are none to disseminate.It takes up to five years to prepare a valid, clinically useful systematic review, and we are barely one year old.Even when our reviews start coming out next year their number will be small because they have to meet the high standards our members have created.None the less, the prospects for their wide dissemination look good.The current use of their forerunner (the pilot Cochrane Pregnancy and Childbirth Database) is dramatically greater than that of its predecessor (TMe Oxford Database of Perinatal Trials),3 and our arrangements with journals such as the BM7, the Lancet, and Annals of Internal Medicine to avoid restrictive copyright, plus our development of versions of Cochrane reviews on the internet, will lead to unprecedented availability ofthe reviews.We feel anything but complacent and welcome suggestions from supporters and inforned critics alike about how we can do better.
Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis.
Authors: A P Cope, M Londei, N R Chu, S B Cohen, M J Elliott, F M Brennan, R N Maini, M Feldmann
Journal: Journal of Clinical Investigation (1994)

Experiments were designed to test the hypothesis that chronic exposure to tumor necrosis factor alpha (TNF) alters the function of activated T lymphocytes. Pretreatment of tetanus toxoid-specific T cell clones with TNF for up to 16 d impaired rechallenge proliferative responses to antigen in a dose- and time-dependent fashion. IL-2 and PHA responses were preserved. Prolonged treatment with TNF impaired production of IL-2, IL-10, IFN gamma, TNF, and lymphotoxin (LT) following stimulation with immobilized OKT3, and resulted in suboptimal expression of the IL-2R alpha chain (Tac) but not CD3, CD4, or HLA-DR antigens, when compared to untreated control cells. By contrast, pretreatment of T cells for prolonged periods in vitro with neutralizing anti-TNF monoclonal antibodies (mAb) enhanced proliferative responses, increased lymphokine production, and upregulated Tac expression following stimulation with OKT3. To determine whether TNF exerts immunosuppressive effects on T cells in vivo, we studied cell-mediated immunity in patients with active rheumatoid arthritis (RA), before and after treatment with a chimeric anti-TNF mAb. Treatment with anti-TNF restored the diminished proliferative responses of PBMC to mitogens and recall antigens towards normal in all patients tested. These data demonstrate that persistent expression of TNF in vitro and in vivo impairs cell-mediated immune responses.
The Labour Ward Handbook
Authors: Laurie Montgomery Irvine
Journal: Journal of the Royal Society of Medicine (2005)

Clinical decisions on the labour ward often have to be made quickly and the choice between management options is seldom guided by the results of randomized controlled trials. For this reason, many units develop their own set of labour ward protocols, based as much on the experience of the senior obstetricians and midwives as on published evidence. The Labour Ward Handbook is based on protocols from the Royal Oldham Hospital.

The first two sections deal with the care of pregnant women and the management of normal and low-risk labour. The third and last covers abnormal and high-risk labour, in six parts including medical and haematological aspects. We begin with those with cornerstones of good labour ward practice communication, documentation and incident reporting, often poorly covered in textbooks but well handled here. Another highly informative section is that on management of latex allery, which seems to be getting more common. If recognized too late in a patient this can lead to cancellation of elective procedures; and in an emergency it can greatly complicate the preparation of operating theatres and equipment, including anaesthetic machines. The book provides a list of all those items of equipment containing latex—some of which, such as cardiotocographic monitors—are not obvious, together with six recent references on latex allergy. I was also impressed by some of the flow diagrams, such as the one on management of a woman with a history of genital herpes.

With its numerous headings and bullet points The Labour Ward Handbook is not something one wants to read from cover to cover. Moreover, the style is dictatorial, with scant discussion of alternative options. It should be read in conjunction with the local labour ward protocol; any differences might generate useful debate on what is best practice. Though this handbook will interest obstetricians of all levels, I would recommend it especially to those sitting examinations, and those writing or updating local labour ward protocols. It is easy to use and encourages further reading with its large number of recent references.
CB-17 * CHARACTERIZATION OF HCMV-ECODED CHEMOKINE RECEPTOR US28 TRANSDUCED MSU1.1 HUMAN FIBROBLAST CELLS
Authors: D. VanBeckum, J. Studt, D. Shaffer, R. Belton, J. Lawrence, R. Rovin, C. Bammert, R. Winn
Journal: Neuro-Oncology (2014)

The Human Cytomegalovirus (HCMV) encodes a G-protein coupled chemokine receptor called US28. Using a mouse model system, US28 was previously found to be oncomodulatory, increasing proliferation, inducing anchorage independent growth and loss of contact inhibition. Similarly, in the human glioblastoma cell line U373, US28 activated VEGF gene expression. In order to determine if US28 is oncomodulatory in a normal human cell, we engineered the human fibroblast cell line MSU1.1 to constitutively express US28 via lentivirus infection. MSU1.1 cells were transduced with pHAGE-US28-ZsGreen. Fluorescent confocal microscopy was utilized to detect the ZsGreen protein tag and confirmed the successful transduction of MSU1.1 cells with the US28 vector or empty pHAGE vector. MSU1.1 cells expressing US28 did not exhibit loss of contact inhibition nor anchorage independent growth in focus formation and soft agar assays, respectively. Using the AlamarBlue assay, MSU1.1 cells expressing US28 showed a 2.303 fold increase in proliferation compared to wild type MSU1.1 cells and a 2.201 fold increase in proliferation compared to mock transduced cells. US28 expression in the immortalized human fibroblast cell line MSU1.1 increased proliferation but did not trigger a transformed phenotype. This study reveals potential cell-type and species-specific differences from previous findings assessing oncogenic and oncomodulatory properties of US28 expression in mammalian cell lines such as NIH-3T3 (mouse fibroblast), and U373 (malignant glioma). Although ectopic expression of US28 does not appear to drive transformation, the reported prevalence in GBM and confirmation of oncomodulation via increased proliferation in MSU1.1 cells makes US28 a potential target warranting further understanding of the virus' role in GBM.
A toddler with pallor and recurrent infection
Authors: R. T Clarke, C. Mitchell
Journal: BMJ (2010)

A 2½ year old girl presented to her general practitioner after several weeks of being, in her mother’s words, “tired and just not herself,” preceded by several months of recurrent upper respiratory tract infections. After positive urinalysis, the general practitioner diagnosed a urinary tract infection. Despite repeated treatment with oral antibiotics, she developed four further urinary tract infections over the next two months. At this time—four months after the initial onset of symptoms—the mother noticed her daughter was pale and lethargic. Over the coming few weeks, she also observed the child’s skin become yellow in colour. Eventually, when her daughter rapidly developed fever, night sweats, and joint pain severe enough to prevent walking, the mother made an emergency appointment at her general practice. The toddler was sent urgently to hospital, where examination elicited hepatosplenomegaly and cervical lymphadenopathy. On admission, she was pancytopenic (haemoglobin 28 g/l , white blood cell count 0.89×109/l, platelets 120×109/l). The blood film confirmed pancytopenia, with occasional teardrop cells but no immature lymphoid cells. The working diagnosis was acute leukaemia.



### 1 What other conditions would you include in your differential and why?

#### Short answer

This child’s initial symptoms were non-specific, although their long duration suggested an underlying disorder such as leukaemia. Recurrent infections suggested immunodeficiency, but as the history unfolded, lethargy and pallor indicated anaemia. The combination of anaemia and jaundice raised the possibility of haemolysis, perhaps, given the infective symptoms, virally induced. Joint pain suggested a septic or juvenile arthritis, but the concurrent anaemia made leukaemia or other malignancy more likely, especially because several joints …
Serum Cholesterol and Mortality Rates in a Native American Population With Low Cholesterol Concentrations
Authors: Anne Fagot-Campagna, Robert L. Hanson, K. M. Venkat Narayan, Maurice L. Sievers, David J. Pettitt, Robert G. Nelson, William C. Knowler
Journal: Circulation (1997)

Low serum cholesterol concentrations are associated with high death rates from cancer, trauma, and infectious diseases, but the meaning of these associations remains controversial. The present report evaluates whether low cholesterol is likely to be a causal factor for mortality from all causes or from specific causes.Among 4553 Pima Indians > or =20 years old, a population with low serum cholesterol (median, 4.50 mmol/L), 1077 deaths occurred during a mean follow-up of 12.8 years. Trauma was the most common cause. The relationship between serum cholesterol measured at 2-year intervals and age- and sex-standardized mortality rates was U-shaped. Cholesterol was related positively to mortality from cardiovascular diseases and diabetes (including nephropathy) and negatively to mortality from cancer and alcohol-related diseases. The relationship was U-shaped for mortality from infectious diseases, and cholesterol was not related to mortality from trauma. Change in cholesterol from one examination to the next was positively related to mortality from diabetes. In proportional-hazards models adjusted for potential confounders, the relationship between baseline cholesterol and mortality was U-shaped for all causes and diabetes and positive for cardiovascular diseases. Other relationships were nonsignificant. Among 3358 subjects followed > or =5 years, the relationship was significant and positive only for mortality from cardiovascular diseases.Despite a high exposure risk for Pima Indians, if low cholesterol level is a causal factor, the relationships between low serum cholesterol and high mortality rates probably result from diseases lowering cholesterol rather than from a low cholesterol causing the diseases.
David John Tooby
Authors: H. Tooby
Journal: BMJ (2013)

David John Tooby was delivered breach by a midwife on the kitchen table. His childhood continued in poverty and hardship on various farms in rural Leicestershire. At the age of 14 he realised that his intellectual abilities (fortunately undimmed by his method of entry into the world) could be the ticket to a less constrained life. The resulting increased application to his studies bore fruit in both a British Council awarded visit to Brazil (as one of the top A level students in the UK in his year) and ultimately a place to study medicine at Barts in the early …
Health Policy Basics: The Physician Payment Sunshine Act and the Open Payments Program
Authors: Neil M. Kirschner, Lois Snyder Sulmasy, Aaron S. Kesselheim
Journal: Annals of Internal Medicine (2014)

The Open Payments program is a government initiative through which financial relationships between applicable industries and covered physicians or teaching hospitals are publicly reported. The program does not assess these relationships but rather facilitates transparency and allows stakeholders to use this information in making informed decisions. This article outlines the program and its goals, reviews its requirements and when they go into effect, examines the implications for physicians and their patients, and makes recommendations to help physicians and teaching hospitals prepare for its implementation.
Maternal asthma and microRNA regulation of soluble HLA-G in the airway
Authors: Jessie Nicodemus-Johnson, Bharathi Laxman, Randi K. Stern, Jyotsna Sudi, Courtney N. Tierney, Lourdes Norwick, Douglas K. Hogarth, John F. McConville, Edward T. Naureckas, Anne I. Sperling, Julian Solway, Jerry A. Krishnan, Dan L. Nicolae, Steven R. White, Carole Ober
Journal: Journal of Allergy and Clinical Immunology (2013)
GPs facing removal from primary care trusts' lists may get legal representation
Authors: Clare Dyer
Journal: BMJ (2006)

The Department of Health in England is to appeal against a High Court ruling last week that it fears could turn the new procedure for striking misbehaving or badly performing doctors off primary care trusts' lists into a lengthy, expensive, and legalistic process.

The judgment from Mr Justice Toulson came in test cases brought by two GPs who argued that a refusal to let them have legal representation, call witnesses, and cross examine witnesses through their lawyers at the oral hearing to decide on their removal …