tbuckley/cabot-search huggingface dataset:
Internal Medicine and Family Medicine
Authors: Clifford F. Feiner
Journal: Annals of Internal Medicine (1996)

Letters15 September 1996Internal Medicine and Family MedicineClifford F. Feiner, DOClifford F. Feiner, DOMount Sinai Services at Queens Hospital Center, Jamaica, NY 11432Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-6-199609150-00045 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In his article on the differences between internal and family medicine practitioners [1], Dr. Saultz did not mention a potential way to facilitate collaboration between the two disciplines. The American Board of Internal Medicine and the American Board of Family Medicine co-sponsor an examination that leads to a Certificate of Added Qualification in Geriatric Medicine. Because residency review committees for both disciplines require each discipline to provide geriatric medical education, internal medicine and family medicine faculty can join in house-staff training. Exposure to the multidisciplinary model necessary to manage the increasing number of functionally impaired elderly is ...REFERENCE1. Saultz JW. Reflections on internal medicine and family medicine. Ann Intern Med. 1996; 124:600-3. Google Scholar Author, Article, and Disclosure InformationAffiliations: Mount Sinai Services at Queens Hospital Center, Jamaica, NY 11432 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1996Volume 125, Issue 6Page: 525KeywordsElderlyGeriatricsMedical educationResidency Issue Published: 15 September 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
New incentives for general practitioners in London
Authors: J. Hayward, M. Modell
Journal: BMJ (1995)

five cellular components for use in paediatrics.Furtherinore, transmission may be compounded by secondary infection of sexual partners and offspring.The cost of preventing a single transmission of the virus has been estimated as C30 000 and the cost of preventing each case of HTLV associated disease as LI -3 million.'With the higher rates of transmission extrapolated above, these figures would be more than halved.Selected screening has been proposed as a cheaper altemative to blanket testing of blood donors.However, selecting whom to screen on the basis of ethnic origin is unlikely to prevent viral transmission.Ethnic origin did not predict HTLV infection in four of the five infected 4 donors in the north London study, nor two of the three HTLV-I positive donors in a Dutch study of selective screening. 13Two of the five infected donors in London and one of the three in Holland had no identifiable risk factors for 4 13 HTLV infection, suggesting that exclusion based on a detailed sexual history is unlikely to prevent transmission either.An altemative approach is to screen first tixne blood donors.This strategy is being used in Sweden, where the prevalence of HTLV infection is approximately half that in Britain. 12 Deciding not to screen for HTLV-I may prove to be a false economy.Recent experience with hepatitis C has shown that the cost of tracing and testing donations retrospectively is considerable and legal costs are likely.Surely the case for screening for HTLV-I in Britain is now clear.
Supervised drug injecting room trial considered a success
Authors: B. Burton
Journal: BMJ (2003)

An evaluation report into an 18 month trial of Australia's first medically supervised injecting centre has cleared the way for the continuation of the $A2.4m (£1m; $US1.6m; €1.4m) a year project.

The 233 page evaluation found that from May 2001 to October 2002, 3810 registered individuals made 56861 visits to the centre. A total of 409 incidents of drug overdose were recorded—including 329 from heroin and 60 from cocaine—though none were fatal.

The report estimates that at least four lives were saved as a result of the proximity of users to medical staff. …
Dynamic determinants of letf ventricular diastolic pressure-volume relations in man.
Authors: W H Gaasch, J S Cole, M A Quinones, J K Alexander
Journal: Circulation (1975)

Left ventricular (LV) diastolic pressure (P), volume (V), and rate of change of volume (dV/dt) were determined at 16.7 msec intervals in 17 patients (simultaneous micromanometer and single plane volume angiography). Four patients had mitral stenosis with atrial fibrillation and 13 patients (three normal, two congestive cardiomyophathy, three LV hypertrophy, and five coronary artery disease) were in normal sinus rhythm. Maximum early diastolic filling rates (max dV/dt) in the normal and cardiomyopathy patients were similar and ranged from 269 to 370 cc/m-2/sec; in coronary artery disease and LV hypertrophy, max dV/dt ranged from 197 to 290 cc/m-2/sec and 213 to 255 cc/m-2/sec respectively; in mitral stenosis, max dV/dt ranged from 215 to 270 cc/m-2 sec. The peak filling rate during atrial systole ranged form 60 to 240 cc/m-2/sec in the 13 patients with sinus rhythm. The instantaneous diastolic P-V data were fit by an exponential equation (P = be-kV) and the P-V relation throughout diastole was represented by the best fit line. The rate constant (k) in the equation was highest in the patient with IHSS and lowest in those with large dilated hearts. In mitral stenosis with atrial fibrillation the fit of the equation to the P-V data appeared better than in the patients with normal sinus rhythm. Peak ventricular filling rate during atrial systole varied directly with LV volume distensibility at the onset of atrial systole (r = 0.64). Data suggest that dynamic mechanical properties of the LV influence the diastolic P-V relations and that pressure "deviations" (deltaP) from the best fit line during atrial systole may be related to viscous drag. In a given ventricle the velocity dependence of deltaP appears to be modified by the volume distensibility of the ventricle. Variable rates of filling may preclude the assumption of an exponential relation between P and V throughout diastole and therefore may limit estimates of diastolic distensibility or compliance which rely on such an assumption.
Urinary retention caused by topical glycopyrrolate for hyperhidrosis
Authors: V. Madan, M.H. Beck
Journal: British Journal of Dermatology (2006)

Journal Article Urinary retention caused by topical glycopyrrolate for hyperhidrosis Get access V. Madan, V. Madan The Dermatology Centre, University of Manchester, School of Medicine, Hope Hospital, Salford, Manchester M6 8HD, U.K E‐mail: vishalmadan@doctors.net.uk Search for other works by this author on: Oxford Academic Google Scholar M.H. Beck M.H. Beck The Dermatology Centre, University of Manchester, School of Medicine, Hope Hospital, Salford, Manchester M6 8HD, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 155, Issue 3, 1 September 2006, Pages 634–635, https://doi.org/10.1111/j.1365-2133.2006.07387.x Published: 01 September 2006
Lipid hydroperoxide modification of proteins during myocardial ischaemia
Authors: P Eaton
Journal: Cardiovascular Research (2001)

Objective: Lipid hydroperoxides (LOOH) are lipid peroxidation products formed during oxidative stress. A component of their cytotoxicity is mediated by the direct modification of proteins. Objectives: (i) To assess whether ischaemia and reperfusion in the isolated rat heart generates LOOH–protein (ii) to characterise the extent, time-course and subcellular localization of any protein adducts formed. Methods: Using a well-characterised antibody which binds to LOOH-modified proteins and densitometry of Western blots, we quantified the amounts of LOOH–protein in control aerobically perfused rat hearts and those subjected to ischaemia with and without reperfusion. Results: Hearts (n=3/4 group), analysed after various periods (0, 5, 10, 20 and 30 min) of zero-flow global ischaemia, exhibited a time-dependent increase in the LOOH-mediated modification of a number of proteins. In hearts subjected to 30 min of ischaemia and then reperfused for various times (0, 5, 10, 20, 30 or 60 min) no changes in LOOH–protein content achieved during the proceeding ischaemic episode were detected. Reperfusion after short periods of ischaemia (5 or 10 min) also did not result in reperfusion-induced LOOH–protein formation. Administration of mercaptopropionylglycine (1 mM) to hearts for 5 min before the onset of 30 min ischaemia efficiently attenuated the formation of LOOH–protein, maintaining the modified proteins at control levels. These Western immunoblot results were confirmed by additional in situ immunofluorescent studies which showed marked LOOH–protein immunostaining in ischaemic tissue around the sarcolemmal membrane. Conclusions: We conclude that the modification of proteins (particularly those associated with sarcolemmal membranes) by LOOH during ischaemia may contribute to the pathophysiology of ischaemic injury. In addition, these modifications may be initiators of oxidant-induced signal transduction pathways. These findings are consistent with an oxidant stress occurring during ischaemia which is not exacerbated or reduced during the first 60 min of reperfusion.
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome
Authors: Sonja I Gringhuis, Tanja M Kaptein, Brigitte A Wevers, Bart Theelen, Michiel van der Vlist, Teun Boekhout, Teunis B H Geijtenbeek
Journal: Nature Immunology (2012)
Urticaria and vasculitis: a continuum of histological and immunopathological changes
Authors: R.RUSSELL JONES, B. BHOGAL, A. DASH, J. SCHIFFERLI
Journal: British Journal of Dermatology (1983)

Histopathological criteria were used to classify twenty-four patients with chronic urticaria into three groups, which were then studied to establish whether circulating immune complexes (CICs), complement activation and deposition of immunoreactants are confined to patients with urticarial vasculitis. Group I (three patients) had classical urticarial vasculitis, and two of these patients showed hypocomplementaemia with evidence of C3 conversion and deposition of immunoreactants in lesional and uninvolved skin. Ten patients (group 2) with a dense perivascular mixed-cellular infiltrate had normal or raised complement levels and infrequent evidence of C3 conversion. Immunoreactants were detected only in their lesional skin. Eleven patients (group 3) had only a sparse perivascular infiltrate. In this group, complement was normal and immunofluorescence was essentially negative. Cryoglobulins were detected in group I patients only. Monoclonal rheumatoid factor and C1q binding were positive in all group I patients, half the group 2 patients and none of the group 3 patients. This study suggests that urticaria and urticarial vasculitis form a disease continuum, and identifies a group of patients with features intermediate between urticarial vasculitis and ordinary urticaria.
Health and Social Care Bill 2011: a legal basis for charging and providing fewer health services to people in England
Authors: A. M. Pollock, D. Price, P. Roderick
Journal: BMJ (2012)

Despite recent amendments to English health bill in response to opposition, <b>Allyson Pollock</b>, <b>David Price</b>, and<b> Peter Roderick </b>argue that it will enable charging for health services that are currently free
Nanoparticle Drug- and Gene-eluting Stents for the Prevention and Treatment of Coronary Restenosis
Authors: Rui-Xing Yin, De-Zhai Yang, Jin-Zhen Wu
Journal: Theranostics (2014)

Percutaneous coronary intervention (PCI) has become the most common revascularization procedure for coronary artery disease.The use of stents has reduced the rate of restenosis by preventing elastic recoil and negative remodeling.However, in-stent restenosis remains one of the major drawbacks of this procedure.Drug-eluting stents (DESs) have proven to be effective in reducing the risk of late restenosis, but the use of currently marketed DESs presents safety concerns, including the non-specificity of therapeutics, incomplete endothelialization leading to late thrombosis, the need for long-term anti-platelet agents, and local hypersensitivity to polymer delivery matrices.In addition, the current DESs lack the capacity for adjustment of the drug dose and release kinetics appropriate to the disease status of the treated vessel.The development of efficacious therapeutic strategies to prevent and inhibit restenosis after PCI is critical for the treatment of coronary artery disease.The administration of drugs using biodegradable polymer nanoparticles as carriers has generated immense interest due to their excellent biocompatibility and ability to facilitate prolonged drug release.Despite the potential benefits of nanoparticles as smart drug delivery and diagnostic systems, much research is still required to evaluate potential toxicity issues related to the chemical properties of nanoparticle materials, as well as to their size and shape.This review describes the molecular mechanism of coronary restenosis, the use of DESs, and progress in nanoparticle drug-or gene-eluting stents for the prevention and treatment of coronary restenosis.
Community medicine and community physicians
Authors: J K Anand
Journal: BMJ (1980)

underlying abdominal pathology needing surgical intervention.Liver function tests are often abnormal in patients with sepsis anywhere; an elevated serum vitamin B12 level is a useful pointer to a source in the liver.3In the three Leicester patients in whom vitamin B12 was measured, two had grossly elevated levels and the third was at the upper limit of normal.We recom- mend vitamin B12 estimation in patients with unexplained pyrexia as delay in the diagnosis of a liver abscess, as you point out, is usually fatal.
NUTRITIONAL EDEMA IN THE DOG
Authors: A. A. Weech, E. Goettsch, E. B. Reeves
Journal: The Journal of Experimental Medicine (1935)

1. The concentration of protein in the serum and plasma of normal dogs is given. Analyses of serum from 38 animals yielded the following averages and standard deviations, (a) for albumin: 3.26 +/- 0.48 gm. per cent, (b) for globulin: 2.72 +/- 0.76 gm. per cent, and (c) for total protein: 5.98 +/- 0.67 gm. per cent. Analyses of plasma from 19 animals showed, (a) for albumin: 3.38 +/- 0.38 gm. per cent, (b) for globulin: 2.98 +/- 0.55 gm. per cent, and (c) for total protein: 6.36 +/- 0.71 gm. per cent. 2. A diet for dogs is described, the feeding of which results in a progressive decline in the concentration of protein in the serum. A composite curve constructed from the findings with 21 animals discloses a rapid initial fall and a slower subsequent decrease in albumin and total protein and an approximately constant level for globulin. The course of the globulin curve was subject to wide variation in separate experiments, both increases and decreases being recorded. 3. With five dogs the nitrogen balance was followed through a total of 42 metabolism periods of approximately 7 days each. The average daily loss of nitrogen was 1.15 gm. Approximate calculations disclose that only 3 or 4 per cent of the nitrogen eliminated is accounted for by the decline in circulating protein, the remainder being represented by loss from the tissues. 4. An episode is described with one dog when, during a period of self-imposed fasting, the serum albumin regenerated to a normal level, apparently at the expense of catabolized tissue protein. 5. The course of serum proteins is described during the recovery which follows interruption of the low protein diet and return to a regime of adequate feeding. 6. A discussion is given of the relationship between tissue proteins and plasma proteins. The data permit one to entertain the hope that a way will be found for stimulating an internal readjustment to provide temporary relief from hypoproteinemia, a way which will depend upon the potential ability of the tissues to provide sufficient protein for the needs of the plasma.
Compelled Medical Treatment of Pregnant Women
Authors: Lawrence J. Nelson
Journal: JAMA (1988)

The authors discuss the ethical aspects of the relationship between physicians and pregnant patients involving the reconciliation of maternal-fetal conflict. They analyze the legal aspects of compulsory treatment of pregnant women and its connection with abortion and child neglect law, with the legal status of the fetus, with legal precedents for intervention, and with physician liability for either honoring or disregarding pregnant patients' refusal of treatment that would benefit the fetus. Nelson and Milliken cite the uncertainty of medical diagnostic and therapeutic techniques and the societal values of autonomy and bodily integrity in opposing judicially compelled treatment of pregnant women. They also contend that pregnant women have an ethical obligation to follow those practices and accept reasonable, nonexperimental treatment that will benefit their fetuses.
James Caldwell Houston
Authors: A. Houston
Journal: BMJ (2013)

Born in Kilbarchan, Renfrewshire, James Caldwell Houston (known universally as “George” to his work colleagues) moved to London aged 7, when his father was promoted to become the London manager of the Clydesdale Bank in Lombard Street.

He attended Mill Hill School as a dayboy and studied Spanish and French. He was awarded a scholarship to Oxford to read modern languages but decided that he would rather be a doctor and discussed this with his headmaster at Mill Hill, Mr Jacks, who, far from trying to change his mind, apparently said: “If you want to study medicine you must go to Guy’s.” He was forever grateful for this advice. Accordingly, he entered Guy’s Hospital Medical School as a first MB medical student in October 1934.

He graduated in time to be told during the Blitz in 1940, with no experience of “gassing”: “You’re a Guy’s man, so you can give anaesthetics,” which he proceeded to do without any further training. He attended to severely injured people, once working for more than 48 hours without sleep. At one point, Guy’s, which had been evacuated to Greenwich, was hit by a bomb, and he was forced to crawl on hands and knees through a pitch black ward and felt a hole in the floor. He would have been killed had he fallen …
Iconographia Gyniatrica: A Pictorial History of Gynecology and Obstetrics
Authors: George D. Wilbanks
Journal: JAMA (1973)

Harold Speert has long exhibited an intense interest in the history of obstetrics and gynecology. His latest and most extensive effort,<i>Iconographia Gyniatrica, A Pictorial History of Gynecology and Obstetrics</i>, contains 929 illustrations of various forms of visual human expression, ranging through picture post cards, cartoons, to classic works of art. The legends and text vary from a simple description to succinct, detailed exposition into which Speert inserts his dry wit appropriately. Actually, the book covers a broader scope than obstetrics and gynecology. The author included illustrations concerning religion, embryology, teratology, and mythology. One would have liked a more critical arrangement. The layout of illustrations, legends, and text is occasionally difficult to follow. The reader can easily get confused in deciding which legend is attached to which figure. More consistency could have been applied to the size of the reproductions, for some simple line drawings filled whole pages, and some
Cyclophosphamide and prednisone induction followed by cyclophosphamide mobilization effectively decreases the incidence of engraftment syndrome in patients with POEMS syndrome who undergo stem cell transplantation
Authors: Victor H. Jimenez‐Zepeda, Suzanne Trudel, Donna E. Reece, Christine Chen, Ahmed M. Rabea, Vishal Kukreti
Journal: American Journal of Hematology (2011)

High-dose chemotherapy with autologous stem cell transplantation (ASCT) can achieve excellent clinical responses in patients with POEMS syndrome (Jimenez Zepeda et al., Blood 2010;116:2403; Gertz et al., Am J Hematol 2005;79:319-328; Gherardi et al., Ann Neurol 1994;35:501-505; Gattinoni et al., Nat Rev Immunol 2006;6:383-393; Salem et al., J Immunol 2009;182:2030-2040; Salem et al., Cancer Immunol Immunother 2010;59:341-353; Salem et al., Cell Immunol 2010;261:134-143). However, High-dose melphalan with ASCT should be considered carefully due to its treatment-related morbidity (Vuckovic et al., Blood 2003;101:2314-2317), especially in patients with poor performance status owing to polyneuropathy and multiorgan involvement, such as cardiac, respiratory, and renal failure. Significant increases in the concentration of circulating macrophage colony-stimulating factor, erythropoietin, IL-6, and TNF-α, reach near maximal values at approximately day +12, predating neutrophil engraftment, and clinically manifest with fever, rash and edema (Dispenzieri et al., Eur J Haematol 2008;80:397-406). Depending on the definition used, approximately 50% of patients satisfied criteria for engraftment syndrome (ES) (Vuckovic et al., Blood 2003;101:2314-2317). ES occurs in 27-47% of patients who undergo ASCT; mortality rate is reported from 8% to 18% (Gattinoni et al., Nat Rev Immunol 2006;6:383-393; Vuckovic et al., Blood 2003;101:2314-2317). We have therefore reviewed our experience with ASCT in patients with POEMS syndrome who were treated with cyclophosphamide and prednisone as induction therapy followed by cyclophosphamide mobilization with an emphasis on treatment-related morbidity and frequency of ES. Our study confirms that ASCT is a feasible and efficacious treatment for patients with POEMS syndrome. In addition, the use of CP followed by cyclophosphamide mobilization decreases the incidence of PES leading to less morbidity and mortality rates.
A strand-specific switch in noncoding transcription switches the function of a Polycomb/Trithorax response element
Authors: Veronika A Herzog, Adelheid Lempradl, Johanna Trupke, Helena Okulski, Christina Altmutter, Frank Ruge, Bernd Boidol, Stefan Kubicek, Gerald Schmauss, Karin Aumayr, Marius Ruf, Andrew Pospisilik, Andrew Dimond, Hasene Basak Senergin, Marcus L Vargas, Jeffrey A Simon, Leonie Ringrose
Journal: Nature Genetics (2014)