tbuckley/cabot-search huggingface dataset:
STAT-ECG Sensor in Cardiac Crises.
Authors: Herbert J. Semler
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971STAT-ECG Sensor in Cardiac Crises.Herbert J. Semler, M.D., F.A.C.P., Lee E. Lauer, Laurel D. SmithHerbert J. Semler, M.D., F.A.C.P.Search for more papers by this author, Lee E. LauerSearch for more papers by this author, Laurel D. SmithSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-821_5 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe time factor is critical in any system designed to treat cardiac arrest and thus to prevent sudden coronary death. The speed with which resuscitation is done is directly related to survival rate. Rapid resuscitation of ventricular fibrillation or asystole occurring outside the hospital is hampered by the unavailability of electrocardiographs. Even in the hospital it may take from 55 to 120 sec to obtain an ECG in emergencies occurring in areas where monitors are absent.To speed diagnosis, an instant cardiac sensor has been developed to record the ECG in less than 3 sec. This portable, battery-operated, hand-held instrument... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Portland, Ore. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 821-822KeywordsElectrocardiographyHeartResuscitationVentricular fibrillation Issue Published: 1 May 1971 PDF DownloadLoading ...
Feeling Unreal: Cognitive Processes in Depersonalization
Authors: Orna Guralnik, James Schmeidler, Daphne Simeon
Journal: American Journal of Psychiatry (2000)

OBJECTIVE: Depersonalization disorder is characterized by a detachment from one’s sense of self and one’s surroundings that leads to considerable distress and impairment yet an intact testing of reality. Depersonalized individuals often report difficulties in perception, concentration, and memory; however, data on their cognitive profiles are lacking. METHOD: Fifteen patients with depersonalization disorder were compared to 15 matched normal comparison subjects on a comprehensive neuropsychological test battery that assessed cognitive function. RESULTS: The subjects with depersonalization disorder showed a distinct cognitive profile. They performed significantly worse than the comparison subjects on certain measures of attention, short-term visual and verbal memory, and spatial reasoning within the context of comparable intellectual abilities. CONCLUSIONS: The authors propose that depersonalization involves alterations in the attentional and perceptual systems, specifically in the ability to effortfully control the focus of attention. These early encoding deficits are hypothesized to have a deleterious effect on the short-term memory system; they manifest as deficits in the ability to take in new information but not in the ability to conceptualize and manipulate previously encoded information.
GASTROENTERITIS DUE TO KANAGAWA NEGATIVE VIBRIO PARAHAEMOLYTICUS
Authors: Shun-Ichi Honda, Ikuo Goto, Ichirou Minematsu, Nagashige Ikeda, Nobuo Asano, Masanori Ishibashi, Yoshio Kinoshita, Mitsuaki Nishibuchi, Takeshi Honda, Toshio Miwatani
Journal: The Lancet (1987)
Vaginal Physiology During Menstruation
Authors: GORM WAGNER
Journal: Annals of Internal Medicine (1982)

We studied 18 young healthy women on the second, fourth, and 14th day of their menstrual cycle. Vaginal fluid was collected for measurement of oxygen and carbon dioxide tension (Po2 and Pco2 and specimens were collected for bacteriologic examination. The vaginal pH was measured at four different sites and the redox potential was measured in the top of the vagina. Staphylococcus aureus was found in three women. The P02 ranged from 0 to 77 mm Hg on day 2; 0 to 76 mm Hg on day 4; and 0 to 53 mm Hg on day 14. The mean PCo2 ( ± SE) was 46 ± 2 mm Hg on day 2; 62 ± 4.5 mm Hg on day 4; and 50.6 ± 8.5 mm Hg on day 14. The mean vaginal pH ( ± SE) was significantly higher on day 2 (6.6 ± 0.3) compared with day 4 (5.3 ± 0.3) and day 14 (4.2 ± 0.2). The redox potential was significantly higher on day 14 compared with day 2 and day 4. No differences were found in values of women who took birth control pills and those of the women who did not.
JEJUNAL IMMUNOPATHOLOGY IN AMYOTROPHIC LATERAL SCLEROSIS AND MULTIPLE SCLEROSIS IDENTIFICATION OF VIRAL ANTIGENS BY IMMUNOFLUORESCENCE
Authors: L.P. Pertschuk, J.D. Broome, D.J. Brigati, A.W. Cook, J.C. Vuletin, E.A. Rainford, J.K. Gupta, D.S. Kim, F. Nidsgorski
Journal: The Lancet (1977)
Observations on the mechanism of hypoxaemia in acute minor pulmonary embolism.
Authors: G H Burton, W A Seed, P Vernon
Journal: BMJ (1984)

An automated computer analysis of ventilation-perfusion lung scans was used to derive graphical data from lung scans of 11 patients with acute minor pulmonary embolism, free of pre-existing cardiorespiratory disease, and with no evidence of intrapulmonary complication or pleural effusion. In each case the analysis showed the presence of areas of lung, remote from those affected by the pulmonary embolism, that had a pathological disturbance of ventilation-perfusion matching with relative overperfusion. Such a disturbance would cause hypoxaemia. When the extent of the mismatching was calculated in terms of relative blood flow and alveolar ventilation it correlated well with the degree of arterial hypoxaemia. It is proposed that in acute minor pulmonary embolism the development of ventilation-perfusion mismatching in areas of lung unaffected by the embolic event may be an important mechanism of hypoxaemia.
Internal Medicine in the Current Health Care Environment: A Need for Reaffirmation
Authors: James P. Nolan
Journal: Annals of Internal Medicine (1998)

Managed care has substantially changed the environment of health care delivery for general internists and internist-subspecialists. In the current system, one may wonder whether detailed and thoughtful workups still have a role when the direction of medical practice increasingly prizes a high volume of brief encounters. However, the very forces that drive managed care make the role of internist in the care of adults even more central. The internist's unique training and clinical approach should lead to both medically effective and cost-effective health care for adults. This type of health care will be increasingly important as the U.S. population ages and an increasing number of Americans have chronic, multisystem disease. Over the past century, internal medicine has evolved from a consultative model to a discipline that encompasses total adult care, from prevention to diagnosis and treatment of acute and chronic illness and from outpatient care in the office to inpatient care in the intensive care unit. However, the leadership role of internists in the medical care of adults is now being threatened by family medicine and by fragmentation within internal medicine itself. Managed care organizations and the general public must be shown why internists are better able than family physicians to meet the health care needs of adults. Furthermore, as the marketplace becomes more competitive, the issue of when care given by a subspecialist is superior to that given by an internist has become more prominent. The rapidly developing "hospitalist" movement also threatens the traditional role of the internist as the caregiver for adults in health and disease. Given the historic flexibility of internal medicine and the assumption that appropriate roles can be defined for family physicians, subspecialists, and hospitalists, internists will continue to play a central role in providing the best care for adults in the new world of health care delivery.
Host-derived CD8+ dendritic cells are required for induction of optimal graft-versus-tumor responses after experimental allogeneic bone marrow transplantation
Authors: Tomomi Toubai, Yaping Sun, Gary Luker, Jun Liu, Kathryn E. Luker, Isao Tawara, Rebecca Evers, Chen Liu, Nathan Mathewson, Chelsea Malter, Evelyn Nieves, Sung Choi, Kenneth M. Murphy, Pavan Reddy
Journal: Blood (2013)
Regional Lung P erf u si on and Ventilation with Radioisotopes in Cervical Cord-injured Patients
Authors: YUTAKA HIRAIZUMI, ETSUO FUJIMAKI, TOYOHIKO HISHIDA, TOSHIAKI MARUYAMA, MASASHI TAKEUCHI
Journal: Clinical Nuclear Medicine (1986)

In general, cervical cord-injured patients present with restrictive pulmonary dysfunction resulting from paralysis of the intercostal muscles. Vital capacity frequently decreases below 50% of that in normal subjects, and their respiratory pattern frequently includes paradoxical movement in which the intercostal spaces sink and the abdomen distends at inspiration. Ventilation scintigraphy using Xe-133 and pulmonary perfusion scintigraphy using Tc-99m macroaggregated albumin (MAA) were performed on nine cervical cord-injured patients and four normal subjects to investigate regional lung functions in the cervical cord-injured patients. Pulmonary perfusion scintigraphy, in which measurement was made in the supine position, revealed no differences between the patients and the normal subjects. The inhomogeneous ventilation/perfusion distribution was presumed to have resulted from change in regional intrapleural pressure due to paradoxical movement of the thoracic cage. Washing and washout times were prolonged by paralysis of the intercostal muscles. These phenomena were particularly apparent in the upper and middle lung regions where compensating action by movement of the diaphragm is small.
INHIBITION OF NF-KB P65 BY RIBOZYME GENE TRANSFER WITH ADENO-ASSOCIATED VIRUS SEROTYPES 9 ATTENUATES POST-INFARCT LEFT VENTRICULAR RUPTURE AND REMODELING IN AGED MICE
Authors: Yi Tong Ma, Yang Xiang, Yining Yang, Fen Liu, Bangdang Chen, Xia Gao, Lei Du
Journal: Journal of the American College of Cardiology (2011)
Anticoagulant Therapy In Transplantation
Authors: Arthur C. Walsh
Journal: JAMA (1972)

ABSTRACT To the Editor.— The article by Griepp et al (221:147,1972) on the use of anticoagulant therapy following cardiac transplantation was very interesting and may have wider implications than even the authors may conceive. The use of anticoagulant therapy in cerebral vascular insufficiency was proved in many patients to be a potent agent in maintaining an adequate circulation to the brain. Years of experience with this type of treatment led me to the hypothesis that the anticoagulant might even prevent the development of arteriosclerosis, or at least slow down its progress (Pa Med 70:51, 1967).Now come the observations of Griepp and his co-workers that show objectively that such anticoagulant therapy may indeed prevent coronary arteriosclerosis. As they say themselves, of course, the number of patients treated is too small to make positive conclusions. Also, they were using some other drugs as well. Combining their experience with observations of my own
Effect of Respiration on Venous Return and Stroke Volume in Cardiac Tamponade
Authors: WARREN G. GUNTHEROTH, BEVERLY C. MORGAN, GAY L. MULLINS, George A. McGough, Donald G. Breazeale
Journal: Circulation Research (1967)

In 40 lightly anesthetized dogs, 5 to 30 days after surgical preparation, flow was measured simultaneously in the venae cavae, pulmonary artery, pulmonary vein, and aorta with ultrasonic flowmeters. Intrapleural and pericardial pressures were measured via silastic cannulas. Pulmonary vein diameter was monitored by miniature mutual inductance coils. In the resting animal with sinus arrhythmia, inspiration increased heart rate and flow in the vena cava, and to a lesser extent, in the pulmonary vein. Left ventricular stroke volume (LVSV) varied directly with the right ventricular stroke volume (RVSV) in dogs with slow heart rates. Cardiac tamponade invariably caused tachycardia and a marked decrease in cardiac output, arterial pressure, pulse pressure, and stroke volume; venous pressure and diameter increased. Pericardial pressure, although markedly elevated, fell with inspiration paralleling the fall in intrapleural pressure. Flow in the pulmonary vein rose or remained constant with inspiration. Pulmonary vein diameter frequently increased with inspiration during tamponade, but only after the pulmonary artery diameter increased with the inspiratory surge. LVSV did not decline sharply with inspiration, and actually increased within 2 beats of the increase in RVSV. The sum of LVSV plus RVSV increased markedly with inspiration, contradicting the concept of fixed intrapericardial volume. Almost all of the changes of pulsus paradoxus reflect the normal respiratory effects on the RVSV, delayed by transit through the pulmonary bed and exaggerated by the small LVSV in a vasoconstricted state.
Quantifying the Eating Abnormalities in Frontotemporal Dementia
Authors: Rebekah M. Ahmed, Muireann Irish, Jonathan Kam, Jolanda van Keizerswaard, Lauren Bartley, Katherine Samaras, John R. Hodges, Olivier Piguet
Journal: JAMA Neurology (2014)

Presence of eating abnormalities is one of the core criteria for the diagnosis of behavioral variant frontotemporal dementia (bvFTD), yet their occurrence in other subtypes of frontotemporal dementia (FTD) and effect on metabolic health is not known.To define and quantify patterns of eating behavior and energy, sugar, carbohydrate, protein, and fat intake, as well as indices of metabolic health in patients with bvFTD and semantic dementia (SD) compared with patients with Alzheimer disease (AD) and healthy control participants.Prospective case-controlled study involving patient and caregiver completion of surveys. Seventy-five participants with dementia (21 with bvFTD, 26 with SD, and 28 with AD) and 18 age- and education-matched healthy controls were recruited from FRONTIER, the FTD research clinic at Neuroscience Research Australia in Sydney.Caregivers of patients with FTD and AD completed validated questionnaires on appetite, eating behaviors, energy consumption, and dietary macronutrient composition. All participants completed surveys on hunger and satiety. Body mass index and weight measurements were prospectively collected.The bvFTD group had significant abnormalities in the domains of appetite (U = 111.0, z = 2.7, P = .007), eating habits (U = 69.5, z = 3.8, P = .001), food preferences (U = 57.0, z = 4.1, P = .001), swallowing (U = 109.0, z = 3.0, P = .003), and other oral behaviors (U = 141.0, z = 2.6, P = .009) compared with the AD group. The bvFTD and SD groups tended to have increased energy consumption. Compared with controls, the bvFTD group had significantly increased carbohydrate intake (251 vs 170 g/d; P = .05) and the SD group had significantly increased sugar intake (114 vs 76 g/d; P = .049). No significant differences in total fat or protein intake between the groups were found. Despite similar energy intake, the SD group had lower hunger and satiety scores compared with the bvFTD group. In contrast, hunger and satiety scores did not differ between the bvFTD group and controls. The abnormal eating behavior was found in the 2 groups (bvFTD and SD) with the highest body mass index (F = 4.2, P = .008) and waist circumference (F = 6.4, P = .001).Abnormal eating behaviors are prominent in patients with bvFTD and those with SD and are not limited to increased appetite. The observed higher intake of sugar and carbohydrates was found in patients with the FTD subtypes and those with higher body mass index and waist circumference and was not explained simply by increased hunger or lower satiety.
Large Thoracic Aortic Aneurysm Seen on Equilibrium Blood Pool Imaging
Authors: ALBERT J. MORENO, ALAN L. CARPENTER, ELMER J. PACHECO, GOTTLIEB L. TURNBULL
Journal: Clinical Nuclear Medicine (1994)

A 70-year-old man with a history of an abdominal aortic aneurysm had facial edema and conjunctival suffusion. A superior vena cava syndrome was subsequently diagnosed with the cause being a large aneurysm of the ascending aorta. Radionuclide ventriculography clearly demonstrated the aneurysm.
Mortality From Myocardial Infarction-Reply
Authors: Eve Weinblatt
Journal: JAMA (1982)

<h3>In Reply.—</h3> It would be rash to quarrel with Dr Monroe's statement that "The modern epidemic of cardiovascular disease will probably be controlled when its causes are thoroughly understood and when medicine and society act to prevent its occurrence." Our recent article was focused on efforts to illuminate the next sentence in Dr Monroe's letter: "This is already happening." Careful estimates<sup>1,2</sup>have concluded that the changes between the 1960s and 1970s in the United States in known coronary risk factors—reduced cigarette smoking among men, reductions in dietary saturated fat, some lowering of serum cholesterol levels, better control of hypertension—were not large enough to have produced the observed 25% change in mortality. Our report, therefore, sought to assess any evidence of better prognosis that might reasonably be ascribed to improved medical management. The data available to us permitted a comparison of long-term prognosis for patients after surviving a first acute MI,
REDUCTION OF SERUM COMPLEMENT IN RABBITS AFTER INJECTION OF ENDOTOXIN
Authors: Verne E. Gilbert, Abraham I. Braude
Journal: The Journal of Experimental Medicine (1962)

Injection into rabbits of a consistently lethal dose of endotoxin regularly produced a rapid and sustained fall of complement levels and lowered the titers of antibody to endotoxin. Doses of endotoxin below the LD(50) lowered complement levels sporadically but not the titers of antibody to endotoxin. The possibility is discussed that complement may be involved in the mechanisms responsible for the lethal action of endotoxin.
Cocaine Analog Coupled to Disrupted Adenovirus: A Vaccine Strategy to Evoke High-titer Immunity Against Addictive Drugs
Authors: Martin J Hicks, Bishnu P De, Jonathan B Rosenberg, Jesse T Davidson, Amira Y Moreno, Kim D Janda, Sunmee Wee, George F Koob, Neil R Hackett, Stephen M Kaminsky, Stefan Worgall, Miklos Toth, Jason G Mezey, Ronald G Crystal
Journal: Molecular Therapy (2011)

Based on the concept that anticocaine antibodies could prevent inhaled cocaine from reaching its target receptors in the brain, an effective anticocaine vaccine could help reverse cocaine addiction. Leveraging the knowledge that E1(-)E3(-) adenovirus (Ad) gene transfer vectors are potent immunogens, we have developed a novel vaccine platform for addictive drugs by covalently linking a cocaine analog to the capsid proteins of noninfectious, disrupted Ad vector. The Ad-based anticocaine vaccine evokes high-titer anticocaine antibodies in mice sufficient to completely reverse, on a persistent basis, the hyperlocomotor activity induced by intravenous administration of cocaine.
Glycemic Control and Bone Age Are Independently Associated With Muscle Capillary Basement Membrane Width in Diabetic Children After Puberty
Authors: D G Rogers, N H White, J V Santiago, J P Miller, V V Weldon, C Kilo, J R Williamson
Journal: Diabetes Care (1986)

This study was undertaken to examine the possible relationships between muscle capillary basement membrane width (CBMW) and glycemic control, bone age, chronologic age, and duration of diabetes in young patients with insulin-dependent diabetes mellitus (IDDM) during different stages of pubertal development. We studied 49 males and 43 females (age, 7-20 yr) with IDDM for up to 16 yr for whom bone age and glycosylated hemoglobin (HbA1c) data were available at the time of right quadriceps muscle biopsy. Based on pubic hair Tanner stage, subjects were assigned to prepubertal (Tanner I), pubertal (Tanner II and III), and postpubertal (Tanner IV and V) groups. In 30 pubertal and prepubertal subjects, none of the variables studied was significantly correlated with CBMW. This is attributable in part to the small number of subjects in each group. In 62 postpubertal subjects, CBMW was correlated with age (r = .27, P = .03), bone age (r = .43, P = .0005), and postpubertal duration of diabetes (r = .38, P = .003) but not total duration of diabetes. In the postpubertal subjects, CBMW was correlated with HbA1c at the time of biopsy (r = .31, P = .01) but correlated more strongly with the mean of HbA1c values obtained during the 1- and 2-yr periods before biopsy (r = .37, P = .01, and r = .54, P = .03, respectively). An analysis of covariance revealed that the slopes for the regression of loge CBMW on HbA1c differed significantly (P = .02) among the three groups.(ABSTRACT TRUNCATED AT 250 WORDS)
ANEMIAS SECONDARY TO GASTRO-INTESTINAL DISEASE, WITH REPORT OF TWO CASES.
Authors: G. W. McCASKEY
Journal: JAMA (1902)

The complex relationship and function of the blood stamps it as a tissue unique in the animal economy. As the common carrier of the body, it is compelled to transport every molecule which passes to and from the tissues, into and out of the organism. It is thus subjected to widely varying influences of both a physiologic and pathologic character to an extent equaled by no other tissue in the body. It is able to maintain the integrity of its function and a distinct autonomy by what may not inaptly be termed its own inherent elasticity of structure. Its cellular elements may be reduced in number under pathologic conditions to 25 per cent, or less of its physiologic standard, and yet perfect recovery be possible. Their most important chemical constituent—hemoglobin—may be reduced in each individual cell to a similar degree, with the same possibilities of restoration to a condition of
Wegener Granulomatosis: An Analysis of 158 Patients
Authors: Gary S. Hoffman, Gail S. Kerr, Randi Y. Leavitt, Claire W. Hallahan, Robert S. Lebovics, William D. Travis, Menachem Rottem, Anthony S. Fauci
Journal: Annals of Internal Medicine (1992)

Objective: To prospectively study the clinical features, pathophysiology, treatment, and prognosis of Wegener granulomatosis. Design: Of the 180 patients with Wegener granulomatosis referred to the National Institute of Allergy and Infectious Diseases during the past 24 years, 158 have been followed for 6 months to 24 years (a total of 1229 patient-years). Measurements: Characteristics of clinical presentation, surgical pathology, course of illness, laboratory and radiographic findings, and the results of medical and surgical treatment have been recorded in a computer-based information retrieval system. Setting: The Warren Magnuson Clinical Center of the National Institutes of Health. Main Results: Men and women were equally represented; 97% of patients were white, and 85% were more than 19 years of age. The mean period of follow-up was 8 years. One hundred and thirty-three patients (84%) received "standard" therapy with daily low-dose cyclophosphamide and glucocorticoids. Eight (5.0%) received only low-dose cyclophosphamide. Six (4.0%) never received cyclophosphamide and were treated with other cytotoxic agents and glucocorticoids. Ten patients (6.0%) were treated with only glucocorticoids. Ninety-one percent of patients experienced marked improvement, and 75% achieved complete remission. Fifty percent of remissions were associated with one or more relapses. Of 99 patients followed for > 5 years, 44% had remissions of > 5 years duration. Thirteen percent of patients died of Wegener granulomatosis, treatment-related causes, or both. Almost all patients had serious morbidity from irreversible features of their disease (86%) or side effects of treatment (42%). Conclusions: The course of Wegener granulomatosis has been dramatically improved by daily treatment with cyclophosphamide and glucocorticoids. Nonetheless, disease- and treatment-related morbidity is often profound. Alternative forms of therapy have not yet achieved the high rates of remission induction and successful maintenance that have been reported with daily cyclophosphamide treatment. Despite continued therapeutic success with cyclophosphamide, our longterm follow-up of patients with Wegener granulomatosis has led to increasing concerns about toxicity resulting from prolonged cyclophosphamide therapy and has encouraged investigation of other therapeutic regimens. Annals of Internal Medicine. 1992;116:488-498.