tbuckley/cabot-search huggingface dataset:
Excursion to International Medical Congress.
Authors: Chas. Wood Fassett
Journal: JAMA (1902)

St. Joseph, Mo., Sept. 23, 1902. <h3>To the Editor:</h3> —I have just made arrangements for conducting a party to Madrid to the International Medical Congress at the expense of $265.00 minimum. The trip can be made in a little over four weeks. This amount will cover all expenses, including first-class ocean passage each way, first-class railway travel, hotel accommodations for fourteen days in Spain, all transfers of baggage, several days sight seeing in Madrid, all fees for hotel service, etc., including the services of a first-class conductor and interpreter. Side trips, of course, can be taken, and the stay extended indefinitely by those who wish to remain longer in foreign countries. The trip will be a most enjoyable one at that season of the year, going and coming via Gibraltar. If you will kindly call attention to this matter in your columns, I shall be under many obligations, stating that
Three Cases of Ovarian Disease Treated by Ovariotomy
Authors: W. Liddon
Journal: BMJ (1864)

arouse the attention of the nurse or the patient who lay in the next bed.POST MIORTEM EXAMINATION.When the glottis was inspected from above before the larynx was opened, it appeared that such was the tumidity of the parts above the cords that no orifice was apparent.This was due to a general condition of cedema, which reached from the inferior vocal cords to the base of the epiglottis; the swelling was greater in sihle latter than in the former situation.There was thickening of' the epiglottis, especially towards its base, and one of its edges was irregularly twisted.The body of the cricoid cartilages was in a great part detached from the tissues in which it is imbed- (led.The upper and inner part was replaced by bone, and this bone retained its unions with the soft parts, though partially separated from the adjoining cartilage.The cartlilaginous part of the structure which composed by far the greatest part of its bulk, was only detached laterally.In a vertical section a channel could be traced completely round it, dividing it posteriorly from the soft parts, anteriorly from the soft parts and its own osseous portion.In a horizontal direction the separation extended irregularly for rather more than an inch.It was incomplete, except opposite to the central part of the body.The channel contained a small quantity of pus, which was most abundant at the upper part of the cartilage, and thence led, burrowing upwards, into a sort of sinus, which extended to a level with the superior vocal cords.The separated cartilage had a natural appearance on section.The submucous cellular tis- sue was thickened by deposit of lymph, especially that coverinig the superior vocal cords, so that these structures were much rounded and enlarged.The inn wes much congested, and there were old cicatrices at both apices.The kidneys were gra- nlular.This case is recorded somewhat fully, since it exemplifies a later stave of the disease than the two pre- ceding ones, and a stage to which, for the most part, all these cases come, unless the disease be arrested by appropriate remedies, namely, necrosis of the la- ryngeal cartilages.In fact, observation seems to prove that many cases of disease of the cartilages of on 25 July
Sensitivity and specificity of optical spectral transmission imaging in detecting joint inflammation in rheumatoid arthritis
Authors: Simon Krabbe, Mads Ammitzbøll-Danielsen, Mikkel Østergaard, Marie-Claude Giard, Lene Terslev
Journal: Annals of the Rheumatic Diseases (2015)

Optical spectral transmission imaging (OI) measures the blood-specific absorption of light transmitted through tissue.1–5 OI of joints may measure the level of inflammation in joint diseases such as rheumatoid arthritis (RA), where the inflammatory process is associated with angiogenesis and increased blood flow.

We compared OI by Hemics Full Hand Proto with colour Doppler (CD) ultrasonography as gold standard reference for inflammation. Sixty-two patients fulfilling the 2010 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) criteria for RA, with no significant deformation of hands or wrists and no surgery for the last 3 months, had OI performed of the wrists and all metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints. Median age was 62 years, 76% were female, median DAS28 was 3.6 and 71% were anti-CCP-positive. Fifty-eight received disease-modifying antirheumatic drugs (synthetic, biological or in combination), five of these in combination with prednisolone. Four patients did not receive antirheumatic treatment. An OI score of …
The Causative Organism in Fort Bragg Fever
Authors: HUGH TATLOCK
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 June 1982The Causative Organism in Fort Bragg FeverHUGH TATLOCK, M.D.HUGH TATLOCK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-6-789 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recent articles on legionella diseases state or imply that Fort Bragg fever was shown to be caused by the gramnegative bacterium bearing my name, now classified as a Legionella species. I am writing to correct this mistake, which is becoming fixed in the literature. This mistake is due to speculation by Hébert and colleagues at the Centers for Disease Control in a recent article in Annals of Internal Medicine (1).The scientific evidence showed to my satisfaction that Fort Bragg fever was caused byLeptospira autumnalisand had nothing to do withLegionella. My reasons for stating...References1. HÉBERTMOSSMCDOUGALBOZEMANMCKINNEYBRENNER GCLFRD. The rickettsia-like organism TATLOCK (1943) and HEBA (1959): bacteria phenotypically similar to but genetically distinct from Legionella pneumophila and the WIGA bacterium. Ann Intern Med. 1980;92:45-52. LinkGoogle Scholar2. TATLOCK H. Reminiscences about Fort Bragg fever. Infect Control. 1981;2:254-5. CrossrefMedlineGoogle Scholar3. WEINSTEIN L. The "new" pneumonias: the doctor's dilemma [Editorial]. Ann Intern Med. 1980;92:559-61. LinkGoogle Scholar1. GOCHENOURSMADELJACKSONEVANSYAGER WJELR. Leptospiral etiology of Fort Bragg fever. Public Health Rep. 1952;67: 811-3. CrossrefMedlineGoogle Scholar2. TATLOCK H. Reminiscences about Fort Bragg fever. Infect Control. 1981;2:254-5. CrossrefMedlineGoogle Scholar3. HEBERTTHOMASONHARRISHICKLINMCKINNEY GBPMR. "Pittsburgh pneumonia agent'': a bacterium phemotypically similar to Legionella pneumophila and identical to the TATLOCK bacterium. Ann Intern Med. 1980;92:53-4. LinkGoogle Scholar4. HELMSJOHNSONDONALDSONCORRY CWMR. Pretibial rash in Legioneolla pneumophila pneumonia. JAMA. 1981;245:1758-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 16 Ward Avenue; Northampton, MA 01060 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1982Volume 96, Issue 6_Part_1Page: 789-790KeywordsFeversLegionellaLeptospira Issue Published: 1 June 1982 PDF DownloadLoading ...
Depression of Cellular Immunity in Pregnancy due to a Serum Factor
Authors: C. A. St. Hill, R. Finn, V. Denye
Journal: BMJ (1973)

Lymphocytes from pregnant women and non-pregnant individuals were cultured under the stimulus of phytohaemagglutinin in the presence of their own and heterologous (allogeneic) sera. The results indicate that heterologous sera have an inhibitory effect on the lymphocyte transformation rate and suggest that the inhibitory property is more powerful in pregnant and fetal sera. Conversely, the addition of heterologous non-pregnant sera to cultures of pregnant lymphocytes increases their transformation rate. These findings suggest that there is a serum inhibitor in pregnancy and this finding may be relevant to the survival of the fetal allograft.
Prognosis in Functional Psychoses; Clinical, Social and Genetic Aspects.
Authors: T. A. Loftus
Journal: JAMA (1963)

One of the most tedious, and therefore one of the most neglected, tasks in psychiatry is the analysis of follow-up data in the functional psychoses. The Scandinavian countries with their relatively small and homogeneous population present some of the best opportunities for this work. The authors have done a comprehensive 5-year follow-up study on all of the first admissions (1102) to the Gaustad Hospital (Norway) between 1938 and 1950. They present conclusions drawn from a multifactorial analysis of clinical, social, hereditary, and physiological (conditioned reflex) factors. Many time-honored prognostic factors were examined, such as length of illness, socioeconomic status, intelligence, heredity, premorbid personality, work record, marital status, and length of illness. The study relies heavily on previous prognostic work by Langfeldt, et al, which, unfortunately, is not summarized adequately although it is frequently referred to in the text. Many American psychiatrists and psychoanalysts will find difficulty in following the authors'
Doctor sues university for breach of academic freedom
Authors: O. Dyer
Journal: BMJ (2001)

A British psychiatrist has launched a £4m ($6m) lawsuit against Canada's largest university, claiming that it rescinded a job offer because of his outspoken opinions on antidepressants.

Dr David Healy, who works at the University of Wales at Bangor, says that his lawsuit against the University of Toronto is the first case of a university being sued for breach of academic freedom.

Dr Healy, aged 47, was offered a professorship at the university in 1999. The post came automatically with the job of clinical director of the mood disorders unit …
Preventing unwanted pregnancies.
Authors: J F Pearson
Journal: BMJ (1991)

This editorial comments on the recent report of the Royal College of Obstetricians and Gynecologists on unplanned pregnancy. This report followed up an earlier report which recommended that the NHS make freely available contraceptive services. Even though this came to fruition, abortion rates continued to rise. In 1990, 174,000 legal abortions were performed in England and Wales, of which 33% were women 20 years. The current report reviewed education and contraceptive services with particular emphasis on teenagers. Unwanted teenage pregnancy was attributed to the lack of education on family planning and related issues in schools. The proposal is for a flexible sex education curriculum with specially trained teachers. Curriculum would be established in national guidelines. A suggested improvement was the addition of seminars for parents and school governors on sex education, even though this means competing with GCSE's. The media should take responsibility for focusing on contraception as a benefit if it continues to promote the delights of sexual intercourse. It is pointed out the emergency contraceptive knowledge is poor. A Family Planning Association (FPA) survey reports that only 1 out of 2 pharmacists receives requests about emergency contraception. Another FPA unpublished study shows that 500 out of 1000 women receiving legal abortions did not use any form of contraception before conception. The need for emergency contraception an appropriate clinic facilities is emphasized. The report also strongly disagrees with the closing of clinics which has been ongoing since the 1974 transfer of FPA clinics to the NHS. The district health authorities must function on a restricted budget while general practitioners in FP are paid from unrestricted funds. Community family planning clinics and general practitioners in the NHS differ considerably in the services offered. Practitioners offer oral contraceptives generally, while clinics provide a wide range of methods. NHS family planning services for contraception, sterilization, and abortion must be reoriented. The recommendation is that senior specialists oversee the community clinics and general practices and coordinate the provision for legal abortion. This specialist might serve as a focus of skill and professionalism for coping with changing social values and medical techniques.
THE PENETRATION OF ULTRAVIOLET RAYS INTO LIVE ANIMAL TISSUES
Authors: D. I. MACHT
Journal: JAMA (1928)

The present advances in the phototherapy of rickets, tuberculosis and other pathologic conditions, together with the recent laboratory observations concerning the physiologic effects of light, have established conclusively that ultraviolet rays produce profound changes in the blood, the metabolism and other physiologic functions of the body. Furthermore, any one at all familiar with the work done along these lines will agree at once that such effects as have been noted and described cannot be ascribed to a "reflex" reaction produced by the sunburn or to irritation of the superficial layers of the epidermis. On the contrary, the striking effects which have been noted render almost inevitable the assumption that the effective ultraviolet rays of energy must penetrate at least as far as the superficial blood circulation in order to produce the various chemical changes which have been repeatedly described. It is therefore surprising to find that the literature on the
Changing patterns of resource allocation in a London teaching district.
Authors: J S Yudkin
Journal: BMJ (1978)

The health plans of the Tower Hamlets district management team were studied to determine what effects the report of the Resource Allocation Working Party and the White Paper "Priorities in the Health and Social Services" have had on resource allocation in a teaching district. The study showed that at present acute services are allocated a greater proportion of the district budget than occurs nationally, while geriatrics, mental health, and community services receive proportionately less. In the next three years spending on acute services is expected to decrease, while spending on geriatric facilities and community services will increase. Nevertheless, cuts in acute services will take place mainly through a reduction in the number of beds serving a community function, concentrating all acute services in the teaching hospital. Services to the district might be better maintained by creating a community hospital to meet the needs of patients who would otherwise need to be accommodated in acute beds with unnecessarily expensive support services.
Lasers in Medicine and Surgery: The Other Issues
Authors: George M. Bohigian
Journal: JAMA (1986)

When the Council on Scientific Affairs appointed an expert Panel on Lasers in Medicine and Surgery, a decision was made to report on the biophysics, safety in use, and clinical applications of lasers. The report of the Panel is in this issue ofTHE JOURNAL.<sup>1</sup> Members of the Panel and the Council recognize that the report does not address important questions about issues such as training and experience required for laser use, credentialing, certification, cost-effectiveness, and appropriate use. "Appropriate use" is a fundamental question. Who should be allowed to use new high-technology instruments and what are the clinical indications for usage? The laser is representative of sophisticated technologies that expand diagnostic and treatment possibilities, but differs from others such as evoked potential testing or magnetic resonance imaging in the interest it attracts for application by a broad range of medical and surgical specialties.<sup>2</sup>Current and potential therapeutic applications of
The Ethos of Doctors and Corporations
Authors: Steven D. Pearson
Journal: Annals of Internal Medicine (1992)

Letters15 August 1992The Ethos of Doctors and CorporationsSteven D. Pearson, MDSteven D. Pearson, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-4-348_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: The issue of power lies at the very heart of Stoeckle and Reiser's timely and insightful article (1) tracing the recent development of authority and governance in hospitals. The coming of the corporation to medicine has stripped physicians of their power. This is also true in the management of ambulatory care, where the tremendous power of corporate administrators has threatened to reduce the human value of primary care to a technical product.This trend has been accompanied by a rising tide of corporate values in medicine. Imperatives for organizational growth and efficiency, incentives to view medical practice...Reference1. StoeckleReiser JS. The corporate organization of hospital work: balancing professional and administrative responsibilities. Ann Intern Med. 1992;116:407-13. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Steven D. Pearson, MDAffiliations: Harvard Community Health Plan Boston, MA 02215 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 1992Volume 117, Issue 4Page: 348-348KeywordsHeartMotivation ePublished: 1 December 2008 Issue Published: 15 August 1992 PDF downloadLoading ...
727-1 The Role of Sympathetic Activity in Murine Myocarditis Leading to the Development of Dilated Cardiomyopathy
Authors: A. Shakir Pandey, Michael J. Sole, John S. Floras, Fayez Dawood, Wen-Hu Wen, Lily Wee, Peter Liu
Journal: Journal of the American College of Cardiology (1995)
Attacks in Greece
Authors: M.J. Friedrich
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Writing and speaking in medicine
Authors: R G Wilkins
Journal: BMJ (1976)

Advice centre for postgraduate medical educationThe three Councils for Postgraduate Medical Education (in England and Wales, Scotland, and Northern Ireland) are setting up a National Advice Centre to advise doctors on opportunities for postgraduate medical edu- cation and training in the United Kingdom.The centre will bring together several separate agencies at present helping doctors (part- icularly those from overseas).The service will incorporate that provided by the BMA for non-members and that run by the British Postgraduate Medical Federation for overseas doctors.The BMA will continue to advise its own members and those of affiliated organ- isations.The centre,
Proteases as prognostic markers in cancer
Authors: H. W Verspaget
Journal: BMJ (1998)

Papers p 829 

Just how tumours become malignant remains an enigma, despite major advances in our knowledge of genetic susceptibility, cellular derailment processes, and environmental factors. The rapid multiplication of cells in the early phase of a tumour does not usually cause serious disease so long as the growth remains confined to its original tissue boundaries. When, however, cells migrate from their original tissue compartment, invade the normal surrounding tissue, and disseminate throughout the body they have become malignant.

The migration and invasion characteristics of malignant cells requires them to be able to cross extracellular barriers. In the primary organ these predominantly consist of basement membranes and connective tissue, collectively called the extracellular matrix. The extracellular matrix is made up of a dense network of different components including laminin, fibronectin and other glycoproteins, collagens, and proteoglycans. To invade and metastasise, tumours possess a lytic machinery made up of different proteolytic enzymes, the proteases. The main classes of proteases contributing to the lytic processes around tumours are cathepsins, plasminogen activators, and matrix metalloproteinases.1 The first evidence of the active part played by these enzymes in neoplastic disease came from studies …
Cytogenetics of Clonal Growths
Authors: Jérome Lejeune
Journal: New England Journal of Medicine (1973)

If neoplastic growth is related to chromosomal changes, a consistent correlation should exist between a particular cell behavior and a particular chromosomal error as stated in the "common-variant" hypothesis.1 As a corollary, all the neoplastic cells should derive from a common ancestor and constitute a clone, carrier of a particular genetic makeup. Thus, the installation of a new clone should be detectable in time if enough samples are analyzed during the course of the disease. In this issue the work of Hecht and his co-workers demonstrates the amount of skill and tenacity required to achieve such a demonstration. Over a . . .
Nitrofurantoin and Peripheral Neuropathy
Authors: ART JACKNOWITZ
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 January 1985Nitrofurantoin and Peripheral NeuropathyART JACKNOWITZ, Pharm. D.ART JACKNOWITZ, Pharm. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-1-138_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The review by Snavely and Hodges (1) provides a clear discussion of the neurotoxic potential of commonly prescribed antimicrobial agents. However, in the section describing agents capable of causing peripheral nerve toxicity, nitrofurantoin was omitted. Indeed, a major problem associated with nitrofurantoin has been the occasional development of polyneuropathy (2).Nitrofurantoin polyneuropathy may develop in patients with normal renal function, if prolonged courses of nitrofurantoin are used. In addition, changes in nerve conduction have been found without clinical features of neuropathy after a 2-week course of nitrofurantoin, 400 mg/d, in healthy volunteers. This complication has also been...References1. SNAVELYHODGES SG. The neurotoxicity of antibacterial agents. Ann Intern Med. 1984;101:92-104. LinkGoogle Scholar2. JACKNOWITZLEFROCKPRINCE AJR. Nitrofurantoin polyneuropathy: report of two cases. Am J Hosp Pharm. 1977;34:759-62. MedlineGoogle Scholar1. SNAVELYHODGES SG. The neurotoxicity of antibacterial agents. Ann Intern Med. 1984;101:92-104. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: West Virginia University Morgantown, WV 26506 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1985Volume 102, Issue 1Page: 138-139KeywordsAntimicrobialsNervesNeuropathyPeripheral neuropathyToxicity Issue Published: 1 January 1985 PDF DownloadLoading ...
CBP/p300 Integrates Raf/Rac-Signaling Pathways in the Transcriptional Induction of NF-ATc during T Cell Activation
Authors: Andris Avots, Mathias Buttmann, Sergei Chuvpilo, Cornelia Escher, Ute Smola, Andrew J Bannister, Ulf R Rapp, Tony Kouzarides, Edgar Serfling
Journal: Immunity (1999)