tbuckley/cabot-search huggingface dataset:
Effector protease receptor 1 mediates the mitogenic activity of factor Xa for vascular smooth muscle cells in vitro and in vivo.
Authors: J Herbert, F Bono, J Herault, C Avril, F Dol, A Mares, P Schaeffer
Journal: Journal of Clinical Investigation (1998)

The binding of 125I-factor Xa to human aortic smooth muscle cell (SMC) monolayers was studied. At 4 degreesC, 125I-factor Xa bound to a single class of binding sites with a dissociation constant value of 3.6+/-0.7 nM and a binding site density of 11,720+/-1,240 sites/cell (n = 9). 125I-factor Xa binding was not affected by factor X, thrombin, or by DX9065, a direct inhibitor of factor Xa, but was inhibited by factor Xa (IC50 = 5.4+/-0.2 nM; n = 9) and by antibodies specific for the effector cell protease receptor 1 (EPR-1), a well-known receptor of factor Xa on various cell types. A factor X peptide duplicating the inter-EGF sequence Leu83-Leu88-(Gly) blocked the binding of 125I-factor Xa to these cells in a dose-dependent manner (IC50 = 110+/-21 nM). Factor Xa increased phosphoinositide turnover in SMCs and when added to SMCs in culture was a potent mitogen. These effects were inhibited by DX9065 and by antibodies directed against EPR-1 and PDGF. Increased expression of EPR-1 was identified immunohistochemically on SMCs growing in culture and in SMCs from the rabbit carotid artery after vascular injury. When applied locally to air-injured rabbit carotid arteries, antibodies directed against EPR-1 (100 mug/ artery) strongly reduced myointimal proliferation 14 d after vascular injury (65-71% inhibition, P < 0.01). DX9065 (10 mg/kg, subcutaneous) inhibited myointimal proliferation significantly (43% inhibition, P < 0.05). These findings indicate that SMCs express functional high affinity receptors for factor Xa related to EPR-1, which may be of importance in the regulation of homeostasis of the vascular wall and after vascular injury.
Safe early revascularization for continuing ischemia after acute myocardial infarction.
Authors: F H Levine, H K Gold, R C Leinbach, W M Daggett, W G Austen, M J Buckley
Journal: Circulation (1979)

Early revascularization following myocardial infarction (MI) is reported to have a high risk of extension of and hemorrhage into infarction with resulting high mortality and morbidity. To evaluate this issue, 80 post-MI patients (aged 32-74 years) with unstable angina pectoris resistant to maximal medical therapy were reviewed. All patients underwent early uncomplicated angiography and subsequent revascularization; 55 (69%) were less than 10 days post-MI, and 25 (31%) were 10-30 days post-MI. Intraaortic balloon pumping was required in 72% for relief of intractable angina or hemodynamic instability. Of the 80 patients, 19% had single vessel disease (VD), 31% double VD, and 50% triple VD. The mortality rate from coronary bypass surgery was 7/80 (8.8%), with four cardiac and three noncardiac deaths. Two patients suffered a perioperative MI (2.5%). At a mean follow-up period of 33 months, there had been only one late death and one recurrent nonfatal MI; 96% of the patients had no significant angina. In patients with continuing ischemia immediately after MI, myocardial revascularization can be safely performed without further injury to the myocardium, and with excellent long-term results.
Up to 20 private hospitals in the UK may have to be sold to increase competition
Authors: M. Limb
Journal: BMJ (2013)

Many patients pay too much for private health treatment because of the “market power” exercised by big hospital groups, a major investigation by the Competition Commission has found.1

The commission’s inquiry into private healthcare found that 101 private hospitals faced little competition, with local markets dominated by the largest groups, BMI, HCA, and Spire. It said that insurers had little choice but to use their local operator, leading to higher premiums and excess profits for hospital groups.

The commission recommended that up to 20 private hospitals in 11 UK locations should be sold off to other operators to widen competition.

The inquiry found a range of anti-competitive restrictions and called for private hospitals to stop offering cash or other incentives to consultants to refer patients to their hospitals …
Health News Reporting: Reply
Authors: Miriam Schuchman
Journal: Annals of Internal Medicine (1997)

Letters15 November 1997Health News Reporting: ReplyMiriam Schuchman, MD and Michael S. Wilkes, MD, PhDMiriam Schuchman, MDState University of New York at Buffalo; Buffalo, NY 14215University of California, Los Angeles; Los Angeles, CA 90095Search for more papers by this author and Michael S. Wilkes, MD, PhDState University of New York at Buffalo; Buffalo, NY 14215University of California, Los Angeles; Los Angeles, CA 90095Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-10-199711150-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:It's true that coverage of a scientific study or a clinical event by a leading news outlet can stimulate a surge of interest by smaller media outlets around the country. This gives a few reporters at such places as The New York Times or “ABC News” a certain amount of influence over national media coverage. In addition, reporters need close contacts with well-placed persons (their sources). To the extent that any one source is relied on too heavily, news reporting may seem biased. Journalists can best protect themselves against biased reporting by turning to an array of qualified ... Author, Article, and Disclosure InformationAuthors: Miriam Schuchman, MD; Michael S. Wilkes, MD, PhDAffiliations: State University of New York at Buffalo; Buffalo, NY 14215University of California, Los Angeles; Los Angeles, CA 90095 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHouseofficers’ reactions to media coverage about the sequencing of the human genome 15 November 1997Volume 127, Issue 10Page: 948KeywordsAvidin biotin complexScientists ePublished: 15 August 2000 Issue Published: 15 November 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Clinical efficacy of reduction in house‐dust mite exposure in specially designed, mechanically ventilated “healthy” homes
Authors: H. Harving, J. Korsgaard, R. Dahl
Journal: Allergy (1994)

In temperate climates, energy-conserving measures may increase indoor humidity, enhancing house-dust mite (HDM) growth. Movement of families to "healthy" homes with mechanical ventilation systems reduced HDM exposure. The effect on asthma control of moving to the "healthy" homes was studied in 14 asthmatic patients allergic to HDM. Base-line evaluations of lung function, asthma symptoms, and medication requirements were made before moving and again after 5 and 15 months' residence. A control group of 11 mite-sensitive asthmatic patients who did not move were examined contemporaneously with the study group at base line and at the first follow-up investigation. After 5 months, the residents of the "healthy" homes improved in forced expiratory volume in 1 s (FEV1), medicine score, and serum IgE. These changes were significantly different from control group measurements. After 15 months, statistically significant improvements from base line were found in FEV1, average daily peak expiratory flow values, medicine score, symptom score, and serum IgE. Insignificant trends toward improvement were seen in provocation concentration of histamine and blood eosinophils. A significant relation was found between reduction in medicine score and fall in HDM exposure. The present study shows that a specific HDM-avoidance procedure can result in an overall, clinical improvement in HDM-sensitive asthmatic patients.
Comparison of Commission on Cancer–Approved and –Nonapproved Hospitals in the United States: Implications for Studies That Use the National Cancer Data Base
Authors: Karl Y. Bilimoria, David J. Bentrem, Andrew K. Stewart, David P. Winchester, Clifford Y. Ko
Journal: Journal of Clinical Oncology (2009)

The Commission on Cancer (CoC) designates cancer programs on the basis of the ability to provide a wide range of oncologic services and specialists. All CoC-approved hospitals are required to report their cancer diagnoses to the National Cancer Data Base (NCDB), and the cancer diagnoses at these hospitals account for approximately 70% of all new cancers diagnosed in the United States annually. However, it is unknown how CoC-approved programs compare with non-CoC-approved hospitals.By using the American Hospital Association Annual Survey Database (2006), CoC-approved and non-CoC-approved hospitals were compared with respect to structural characteristics (ie, accreditations, geography, and oncologic services provided).Of the 4,850 hospitals identified, 1,412 (29%) were CoC-approved hospitals, and 3,438 (71%) were not CoC-approved hospitals. The proportion of CoC-approved hospitals varied at the state level from 0% in Wyoming to 100% in Delaware. Compared with non-CoC-approved hospitals, CoC-approved programs were more frequently accredited by the Joint Commission, designated as a Comprehensive Cancer Center by the National Cancer Institute, and affiliated with a medical school or residency program (P < .001). CoC-approved hospitals were less likely to be critical access hospitals or located in rural areas (P < .001). CoC-approved hospitals had more total beds and performed more operations per year (P < .001). CoC-approved programs more frequently offered oncology-related services, including screening programs, chemotherapy and radiation therapy services, and hospice/palliative care (P < .001).Compared with non-CoC-approved hospitals, CoC-approved hospitals were larger, were more frequently located in urban locations, and had more cancer-related services available to patients. Studies that use the NCDB should acknowledge this limitation when relevant.
Economics of Cosmetic Surgery
Authors: E. F. Wilson
Journal: BMJ (1967)

tion of cases of mitral stenosis should provide the proof, however.An additional slight corrective may be worth while in case nihilistic conclusions be drawn on the therapeutic value of cardioversion.As it is emphasized in the title, at least, the evidence presented only refers to right ventricular output.If true, my alter- native explanation of reduced benefit in patients with symptoms implies there could still be full benefit for left ventricular output.-Iam, etc.,
Adverse Events Associated With Stopping Clopidogrel After Acute Coronary Syndrome
Authors: Dae Hyun Kim
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PROCEDURAL AND LONG-TERM CLINICAL OUTCOMES AFTER PERCUTANEOUS CORONARY INTERVENTION OF CHRONIC TOTAL OCCLUSIONS IN WOMEN: A REPORT FROM THE MULTINATIONAL CTO REGISTRY
Authors: Bimmer E. Claessen, Kotaro Obunai, Cosmo Godino, Sunil Kanwal, Mauro Carlino, Young-Hak Kim, Carlo DiMario, Seung-Jung Park, Gregg W. Stone, Antonio Colombo, George D. Dangas, Jeffrey W. Moses, Martin B. Leon, Roxana Mehran
Journal: Journal of the American College of Cardiology (2011)
Psychopathology in 15,909 Pairs of Veteran Twins: Evidence for a Genetic Factor in the Pathogenesis of Schizophrenia and Its Relative Absence in Psychoneurosis
Authors: WILLIAM POLLIN, MARTIN G. ALLEN, AXEL HOFFER, JAMES R. STABENAU, ZDENEK HRUBEC
Journal: American Journal of Psychiatry (1969)

In a large twin series the monozygotic pair concordance rate for schizophrenia was found to be 3.3 times greater than the dizygotic rate. In contrast, the difference for psychoneurosis was only 1.3. Reanalysis of 18 earlier major twin studies revealed a similar difference in all but one instance. This consistent difference suggests the presence of a genetic factor in the pathogenesis of schizophrenia and its relative absence in psychoneurosis. However, the role of the suggested genetic factor appears to be a limited one; 85 percent of the affected monozygotic pairs in the sample were discordant for schizophrenia.
Lichen sclerosus associated with prolectinoma
Authors: S.N. Chang, S.H. Lee, S.K. Ahn
Journal: British Journal of Dermatology (1994)

Journal Article Lichen sclerosus associated with prolectinoma Get access S.N. Chang, S.N. Chang Department of Dermatology. Yonsei University College of Medicine. Seoul. Korea Search for other works by this author on: Oxford Academic Google Scholar S.H. Lee, S.H. Lee Department of Dermatology. Yonsei University College of Medicine. Seoul. Korea Search for other works by this author on: Oxford Academic Google Scholar S.K. Ahn S.K. Ahn Department of Dermatology, Yonsei University, Wonju College of Medicine, Wonju, Korea Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 131, Issue 3, 1 September 1994, Page 448, https://doi.org/10.1111/j.1365-2133.1994.tb08539.x Published: 01 September 1994
Construction of 3D, Layered Skin, Microsized Tissues by Using Cell Beads for Cellular Function Analysis
Authors: Yuya Morimoto, Risa Tanaka, Shoji Takeuchi
Journal: Advanced Healthcare Materials (2012)

Microsized skin cell beads consisting of 3D layered structures with epidermal and dermal cells have been fabricated. The beads are monodisperse, type-I collagen beads encapsulating dermal cells and covered by epidermal cells. The beads can be used in individual analyses of cellular functions and respond to chemical stimulation. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Clinical Trial of Emepronium Bromide in Nocturnal Frequency of Old Age
Authors: J. C. Brocklehurst, J. B. Dillane, J. Fry, P. Armitage
Journal: BMJ (1969)

A double-blind cross-over trial of emepronium bromide (Cetiprin) in nocturnal frequency of micturition in a group of elderly women living in their homes showed that the drug was superior to placebo in diminishing urinary frequency, though not every person benefited. It is suggested that the drug may alter the established habit of rising at night to pass urine. Side-effects were negligible.
Histamine and Glucagon Tests in Diagnosis of Pheochromocytoma
Authors: Sheldon G. Sheps
Journal: JAMA (1968)

The glucagon hydrochloride test of Lawrence was compared with the standard cold pressor-histamine test in 12 patients with pheochromocytoma and in 35 control patients without tumor. Urinary and blood catecholamine levels and the values for urinary vanilmandelic acid and total metanephrine were also determined. One patient without a tumor had a pressor response after receiving histamine; none had a pressor response after receiving glucagon. Eleven patients with tumor were given 1 mg of glucagon; six had a positive pressor response, and four of these six had a positive response after receiving histamine as well. One patient with tumor responded positively to histamine but not to 0.5 mg of glucagon. Although determination of the level of urinary metanephrine remains the preferred screening test for pheochromocytoma, when adjunctive studies are desired we recommend the cold pressor-glucagon test (1 mg) instead of histamine as the standard provocative pharmacologic test for pheochromocytoma.
Distance between Patients’ Subjective Perceptions and Objectively Evaluated Disease Severity in Chronic Heart Failure
Authors: Francesco Grigioni, Samuela Carigi, Silvana Grandi, Luciano Potena, Fabio Coccolo, Letizia Bacchi-Reggiani, Gaia Magnani, Eliana Tossani, Anna Chiara Musuraca, Carlo Magelli, Angelo Branzi
Journal: Psychotherapy and Psychosomatics (2003)

&lt;i&gt;Background:&lt;/i&gt; Chronic heart failure (CHF) is a socially relevant condition carrying an adverse prognosis. Systematic analysis is needed of the relationship between quality of life (QoL) – what patients are most interested in – and objective parameters of CHF severity – which largely determines physicians’ care. &lt;i&gt;Methods:&lt;/i&gt; We prospectively investigated QoL, as ascertained by the Minnesota Living with Heart Failure Questionnaire, alongside all the currently used objective clinical/instrumental (electrocardiographic, echocardiographic, hemodynamic and functional capacity) indicators of disease severity in 106 consecutive CHF patients. &lt;i&gt;Results:&lt;/i&gt; Besides persistence of sinus rhythm (p = 0.007), the only objective parameters that correlated with QoL were NYHA class (p &lt; 0.001) and distance covered during the six minutes walking test (p &lt; 0.001) (two indications of patients’ ability to attend to their daily needs). Presence of left bundle branch block was associated with a worse QoL only in patients with CHF due to ischemic heart disease (p = 0.032). All the other clinical/instrumental parameters showed no relation with QoL (p &gt; 0.150 in all cases). &lt;i&gt;Conclusions:&lt;/i&gt; Objective indicators of disease severity, which largely determine physicians’ care, appear to have little bearing on QoL, suggesting that current treatment for CHF fails to satisfy patients’ perceived needs. The possibility of cost-effective nonpharmaceutical therapeutic protocols (e.g. psychological interventions) specifically designed to improve patients’ QoL deserves investigation as a much needed new approach to the management of CHF.
Luminal narrowing after percutaneous transluminal coronary angioplasty. A study of clinical, procedural, and lesional factors related to long-term angiographic outcome. Coronary Artery Restenosis Prevention on Repeated Thromboxane Antagonism (CARPORT) Study Group.
Authors: B J Rensing, W R Hermans, J Vos, J G Tijssen, W Rutch, N Danchin, G R Heyndrickx, E G Mast, W Wijns, P W Serruys
Journal: Circulation (1993)

BACKGROUND The renarrowing process after successful percutaneous transluminal coronary angioplasty (PTCA) is now believed to be caused by a response-to-injury vessel wall reaction. The magnitude of this process can be assessed by the change in minimal lumen diameter (MLD) at follow-up angiography. The aim of the present study was to find independent patient-related, lesion-related, and procedure-related risk factors for this luminal narrowing process. A model that accurately predicts the amount of luminal narrowing could be an aid in patient or lesion selection for the procedure, and it could improve assessment of medium-term (6 months) prognosis. Modification or control of the identified risk factors could reduce overall restenosis rates, and it could assist in the selection of patients at risk for a large loss in lumen diameter. This population could then constitute the target population for pharmacological intervention studies. METHODS AND RESULTS Quantitative angiography was performed on 666 successfully dilated lesions at angioplasty and at 6-month follow-up. Multivariate linear regression analysis was performed to obtain variables with an independent contribution to the prediction of the absolute change in minimal lumen diameter. Diabetes mellitus, duration of angina &lt; 2.3 months, gain in MLD at angioplasty, pre-PTCA MLD, lesion length &gt; or = 6.8 mm, and thrombus after PTCA were independently predictive of change in MLD. Overall prediction of the model was poor, however, percentage-correct classification for a predicted change between -0.1 to -0.4 mm was approximately 10%. Lesions showing no change or regression (change &gt; -0.1 mm) and lesions showing large progression (&lt; or = -0.4 mm) were more predictable (correct classification, 59.5% and 49.7%, respectively). CONCLUSIONS Renarrowing after successful PTCA as determined with contrast angiography is a process that cannot be accurately predicted by simple clinical, morphological, and lesion characteristics.
Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A Consensus Statement From the American Diabetes Association and the European Association for the Study of Diabetes
Authors: Philip E. Cryer
Journal: Diabetes Care (2006)

The consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes published in both Diabetologia (1) and Diabetes Care (2) included the following statement concerning the incidence of hypoglycemia in insulin-treated type 2 diabetes: “In clinical trials aimed at normoglycemia and achieving a mean A1C of ∼7%, severe hypoglycemic episodes (defined as requiring help from another person to treat) occurred at a rate of between 1 and 3 per 100 patient-years.” This is not a balanced description of the published literature.

The authors cited five publications to support the statement quoted (3–7). However, two of those do not include event rates for severe hypoglycemia as defined in the statement (5,6), and one was a review with …
In Vivo and In Vitro Resistance to Sulfadiazine in Strains of Neisseria Meningitidis
Authors: Jack W. Millar
Journal: JAMA (1963)

MENINGOCOCCAL INFECTIONS are relatively common at military recruit camps. In World War I, for example, carrier rates of 60% or more were commonplace throughout the US camps and the number of clinical cases of meningococcal disease were appropriately great. During World War II an outbreak of meningococcal disease began among military bases and spread to the US civilian population. Before the epidemic had run its course during the years 1943 and 1944, some 34,000 persons had become ill and 4,700 of them had died as a result of meningococcal disease. At the beginning of World War II, a number of workers throughout the world<sup>1-5</sup>had reported the use of sulfonamides for treatment of meningococcal meningitis and had, in addition, indicated that sulfonamides might be used to eliminate the meningococcal carrier state in otherwise healthy individuals, thereby limiting the spread of infection to susceptible persons. In 1943 Awe, Babione,
Paroxysmal nocturnal hemoglobinuria clone in patients with myelodysplastic syndrome
Authors: Mustafa N. Yenerel, Reyhan Diz‐Kucukkaya, Sevgi Besisik, Melih Aktan, Meliha Nalcaci, Günçag Dincol, Abdullah Hacihanefioglu, Mehmet Turgut
Journal: American Journal of Hematology (2001)
Central Retinal Artery Occlusion: Local Intra-arterial Fibrinolysis versus Conservative Treatment, a Multicenter Randomized Trial
Authors: Martin Schumacher, Dieter Schmidt, Bernhard Jurklies, Christine Gall, Isabel Wanke, Claudia Schmoor, Herbert Maier-Lenz, Laszlo Solymosi, Hartmut Brueckmann, Aljoscha S. Neubauer, Armin Wolf, Nicolas Feltgen
Journal: Ophthalmology (2010)