tbuckley/cabot-search huggingface dataset:
Prognostic Values of Clockwise and Counterclockwise Rotation for Cardiovascular Mortality in Japanese Subjects
Authors: Yasuyuki Nakamura, Tomonori Okamura, Aya Higashiyama, Makoto Watanabe, Aya Kadota, Takayoshi Ohkubo, Katsuyuki Miura, Fumiyoshi Kasagi, Kazunori Kodama, Akira Okayama, Hirotsugu Ueshima
Journal: Circulation (2012)

Although clockwise rotation and counterclockwise rotation are distinct findings of the ECG, their prognostic significance is rarely studied.We studied prognostic values of clockwise and counterclockwise rotation on total, cardiovascular disease (CVD), and subtype mortality using the National Integrated Project for Prospective Observation of Noncommunicable Disease and Its Trends in the Aged, 1980-2004 (NIPPON DATA80) database with a 24-year follow-up. At baseline in 1980, data were collected on study participants aged ≥30 years from randomly selected areas in Japan. We followed 9067 participants (44% men; mean age, 51 years). During the 24-year follow-up, mortality was as follows: 2581 total, 887 CVD, 179 coronary heart disease, 173 heart failure, and 411 stroke. The multivariate-adjusted hazard ratio (HR) with the use of the Cox model including biochemical and other ECG variables revealed that clockwise rotation was significantly positively associated with heart failure in men and women combined (HR=1.79; 95% confidence interval [CI], 1.13-2.83; P=0.013), CVD in men and in men and women combined (HR=1.49; 95% CI, 1.12-1.98; P=0.007 in men; HR=1.28; 95% CI, 1.02-1.59; P=0.030 in combined), and total mortality in men and in men and women combined (HR=1.19; 95% CI, 1.00-1.49; P=0.0496 in men; HR=1.15; 95% CI, 1.00-1.32; P=0.045 in combined). Counterclockwise rotation was significantly inversely associated stroke in men and women combined (HR=0.77; 95% CI, 0.62-0.96; P=0.017), CVD in men and in men and women combined (HR=0.74; 95% CI, 0.59-0.94; P=0.011 in men; HR=0.81; 95% CI, 0.70-0.94; P=0.006 in combined), and total mortality in women (HR=0.87; 95% CI, 0.77-0.98; P=0.023).We found a significant positive association of clockwise rotation and a significant inverse association of counterclockwise rotation with CVD mortality in men and in men and women combined, independent of confounding factors including other ECG changes.
Genetics of Atopic Dermatitis
Authors: Sabine Duchatelet, Alain Hovnanian
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Correlation of Ischemia-Induced Extracellular and Intracellular Ion Changes to Cell-to-Cell Electrical Uncoupling in Isolated Blood-Perfused Rabbit Hearts
Authors: Lisa M. Owens, Teresa A. Fralix, Elizabeth Murphy, Wayne E. Cascio, Leonard S. Gettes
Journal: Circulation (1996)

Background The relationships between the metabolic, ionic, and electrical changes of acute ischemia have not been determined precisely because they have been studied under different experimental conditions. We used ion-selective electrodes, nuclear magnetic resonance spectroscopy, and the four-electrode method to perform four series of experiments in the isolated blood-perfused rabbit heart loaded with 5F-BAPTA during 30 to 35 minutes of no-flow ischemia. We sought to determine the relationship between changes in phosphocreatine (PCr), adenosine triphosphate (ATP), intracellular calcium ([Ca 2+ ] i ), intracellular pH (pH i ), extracellular potassium ([K + ] e ), extracellular pH (pH e ), and whole-tissue resistance (r t ). Methods and Results In the first 8 minutes of ischemia, [K + ] e rose from 4.9 to 10.8 mmol/L, PCr fell by 90%, ATP decreased by 25%, and pH i and pH e decreased by 0.5 U, while [Ca 2+ ] i and r t changed only slightly. Between 8 and 23 minutes, [K + ] e changed only slightly; pH i , pH e , and ATP continued to fall, and [Ca 2+ ] i rose. r t did not increase until &gt;20 minutes of ischemia, when pH i was &lt;6.0 and [Ca 2+ ] i had increased more than threefold. The increase in r t , indicating electrical uncoupling, coincided with the third phase of the [K + ] e change. Conclusions Our study suggests that cellular uncoupling occurs only after a significant rise in [Ca 2+ ] i and fall in pH i and that these ionic and electrical changes can be identified by the change in [K + ] e . Our study underscores the importance of using a common model while attempting to formulate an integrated picture of the ionic, metabolic, and electrical events that occur during acute ischemia.
Role of Metformin Accumulation in Metformin-Associated Lactic Acidosis
Authors: Jean D Lalau, Christian Lacroix, Patricia Compagnon, Bertrand de Cagny, Jean P Rigaud, Gérard Bleichner, Paul Chauveau, Patricia Dulbecco, Claude Guérin, Jean M Haegy, Philippe Loirat, Bruno Marchand, Yves Ravaud, Philippe Weyne, Albert Fournier
Journal: Diabetes Care (1995)

To investigate the role of metformin accumulation in the pathophysiology of metformin-associated lactic acidosis.We used high-performance liquid chromatography to measure plasma metformin concentrations in 14 patients who experienced lactic acidosis (pH < 7.35 and lactate concentration 5 > mmol/l) while receiving chronic metformin treatment. Their treatment was generally based on alkalinization and dialysis therapy.Clinical shock and/or evidence of tissue hypoxia was found in all patients with the exception of one who had a nonsteroidal anti-inflammatory drug-induced anuria. Ten patients had significant metformin accumulation (plasma metformin concentrations 4.1-84.9 mg/l, normal value 0.6 +/- 0.5 mg/l before drug intake), generally because of failure to withdraw metformin despite intercurrent pathological conditions affecting its renal elimination (serum creatinine concentrations ranging from 269 to 1,091 mumol/l). There was no metformin accumulation (plasma metformin 0.03-0.7 mg/l) in the four other patients, who had less severe renal failure (serum creatinine 140-349 mumol/l). The severity of the patient's general condition did not predict early hospital mortality (death before discharge from the intensive care unit) even in patients in shock. Whereas it was high in those without metformin accumulation (only 1 of 4 patients recovered), early hospital mortality was low in the 10 patients with metformin accumulation and was not related to its extent (3 patients died with end-stage hepatic failure or cardiac failure). Correlation studies showed a positive correlation between serum creatinine and plasma metformin and between plasma metformin and arterial lactate but, for the latter correlation, only in patients with metformin accumulation.Metformin-associated lactic acidosis is not necessarily due to metformin accumulation; true type B (aerobic) lactic acidosis, i.e., without an apparent associated hypoxic factor, seems exceptional. Neither the severity of the clinical picture nor the degree of metformin accumulation predicted survival; rather, the prognosis was dependent upon the severity of the associated pathological conditions.
Metabolic protection by verapamil during graded coronary flow reduction independent of effect on baseline systolic function. Separation of mechanical and ionic markers of ischemia.
Authors: M G Jenkins, T A Johnson, C Engle, L S Gettes
Journal: Circulation (1989)

Pretreatment with the calcium channel-blocking agent verapamil lowers the coronary flow associated with the first rise in myocardial extracellular potassium [( K+]e). The mechanisms underlying this effect are unclear. It is not known whether this effect is a manifestation of verapamil-induced reduction in baseline cardiac work before the reduction in coronary flow, is dependent on a selective depression of contractility within the low-flow region, or is independent of an effect on myocardial work. This study was performed to determine the relations between changes in regional contractility and [K+]e before and after verapamil (0.2 mg/kg followed by 6.5 micrograms/kg/min) when left anterior descending (LAD) coronary flow is progressively reduced and when verapamil-induced alterations in baseline myocardial work are prevented by atrial pacing and by dobutamine (4.3 +/- 2.2 micrograms/kg/min) to maintain systemic arterial blood pressure and contractility. Before verapamil-dobutamine, myocardial [K+]e rose and regional contractility fell when LAD coronary flow was reduced to 87.7 +/- 9.6% and 83.4 +/- 7.4%, respectively, of the unrestricted control value (p = NS). After verapamil-dobutamine, the threshold flow for rise in [K+]e decreased to 56.4 +/- 13.5% of the unrestricted control flow (p = 0.003), but the threshold flow for regional contractility fall was unchanged (84.8 +/- 11.3%). Our results indicate that the protective effect of verapamil on preventing ischemia-induced [K+]e release is not dependent on a reduction in baseline myocardial work. In this setting, calcium channel blockade by verapamil results in a dissociation between the ionic and mechanical events that occur when coronary flow is reduced.
Induction of mixed-function oxidases in mouse liver by psoralens
Authors: BARBARA B. MANDULA, MADHU A. PATHAK, YASUHISA NAKAYAMA, SAMUEL J. DAVIDSON
Journal: British Journal of Dermatology (1978)

Journal Article Induction of mixed‐function oxidases in mouse liver by psoralens Get access BARBARA B. MANDULA, BARBARA B. MANDULA Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar MADHU A. PATHAK, MADHU A. PATHAK Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, U.S.A. Dr Madhu A. Pathak, Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar YASUHISA NAKAYAMA, YASUHISA NAKAYAMA Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar SAMUEL J. DAVIDSON SAMUEL J. DAVIDSON Department of Bio‐Research Institute, Cambridge, MA 02141, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 99, Issue 6, 1 December 1978, Pages 687–691, https://doi.org/10.1111/j.1365-2133.1978.tb07064.x Published: 01 December 1978
Delayed Laceration of Ulnar Nerve Following Hand Trauma
Authors: Edward V. Craig
Journal: JAMA (1985)

IT IS imperative that when a patient is seen with a traumatic hand laceration, if the instrument causing the laceration cannot be identified or is unknown, adequate x-ray films be obtained to ensure that potentially dangerous foreign bodies are not embedded in the tissue. These can migrate even after primary wound healing and cause delayed or secondary trauma exceeding the initial episode. The following case illustrates the tragic consequences of failure to include proper roentgenographic studies as part of the initial evaluation of hand trauma. <h3>Report of a Case</h3> A 20-year-old man was seen in the emergency room after falling on his outstretched right hand in a rock quarry. On initial examination, a laceration over the base of the hypothenar eminence from the pisiform bone to the hook of the hamate bone was noted. The patient complained of no neurological symptoms referable to the area, and the results of neurological
Overuse of Pulmonary Flow Catheters
Authors: ROLAND B. MCGRATH
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 December 1985Overuse of Pulmonary Flow CathetersROLAND B. MCGRATH, M.D.ROLAND B. MCGRATH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-6-954 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Eugene Robin (1), in his recent perspective, claims that pulmonary artery balloon flotation catheters are used extraordinarily frequently, usually for economic advantage, by physicians who show a cavalier approach in intensive care units by placing catheters routinely without appreciating the risks of catheter use and, therefore, seldom applying any risk-benefit analyses. It is important to respond to those opinions.I endorse Robin's pleas for the use of catheters to study specific clinical questions and for additional clinical research to identify patients in whom a risk-benefit analysis would favor catheter insertion. Robin cites the experience of Dawkins and...References1. ROBIN E. The cult of the Swan-Ganz catheter: overuse and abuse of pulmonary flow catheters. Ann Intern Med. 1985;103:445-9. LinkGoogle Scholar2. DAWKINSJAMIESONHUNT KSS. Long-term results, hemodynamics, and complications after combined heart and lung transplantation. Circulation. 1985;71:919-26. CrossrefMedlineGoogle Scholar3. EISENBERGJAFFESCHUSTER PAD. Clinical evaluation compared to pulmonary artery catheterization in the hemodynamic assessment of critically ill patients. Crit Care Med. 1984;12:549-53. CrossrefMedlineGoogle Scholar4. DEL GUERCIOCOHN LJ. Monitoring operative risk in the elderly. JAMA. 1980;243:1350-5. CrossrefMedlineGoogle Scholar1. ROBIN E. The cult of the Swan-Ganz catheter: overuse and abuse of pulmonary flow catheters. Ann Intern Med. 1985;103:445-9. LinkGoogle Scholar1. ROBIN E. The cult of the Swan-Ganz catheter: overuse and abuse of pulmonary flow catheters. Ann Intern Med. 1985;103:445-9. LinkGoogle Scholar1. ROBIN E. The cult of the Swan-Ganz catheter: overuse and abuse of pulmonary flow catheters. Ann Intern Med. 1985;103:445-9. LinkGoogle Scholar1. ROBIN E. The cult of the Swan-Ganz catheter: overuse and abuse of pulmonary flow catheters. Ann Intern Med. 1985;103:445-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Wishard Memorial Hospital-Indiana University Medical Center Indianapolis, IN 46202 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByInvasive bedside hemodynamic monitoring 1 December 1985Volume 103, Issue 6_Part_1Page: 954-955KeywordsCathetersIntensive care unitsPulmonary arteries Issue Published: 1 December 1985 PDF DownloadLoading ...
Dependence of Augmentation of Arterial Endothelial Cell Expression of Plasminogen Activator Inhibitor Type 1 by Insulin on Soluble Factors Released From Vascular Smooth Muscle Cells
Authors: David J. Schneider, P. Marlene Absher, Michael A. Ricci
Journal: Circulation (1997)

Background Insulin-resistant states are characterized by accelerated atherosclerosis and are associated with increased plasma concentrations of insulin and plasminogen activator inhibitor type 1 (PAI-1). To determine whether arterial expression of PAI-1 in response to insulin contributes to the increased PAI-1 observed, human and porcine arteries in culture were exposed to insulin, and results were compared with responses of specific arterial cellular constituents maintained in culture and coculture. Methods and Results Human and porcine arterial segments and cells obtained from arteries were maintained in culture. Insulin increased accumulation of PAI-1 in conditioned medium from arterial segments (ng PAI-1 [1 nmol/L insulin minus control]: human arteries 47±17, porcine arteries 3.1±1.2, P &lt;.05 for each) and from endothelial cells (ECs) cocultured with smooth muscle cells (SMCs, ng PAI-1 [1 nmol/L insulin minus control]: human cells 43±8, porcine cells 0.5±0.1, P &lt;.05 for each). Insulin had no effect on EC expression of PAI-1 when not cocultured with SMCs. Increased accumulation of PAI-1 was seen when ECs, in coculture chambers without SMCs, were cultured with medium previously conditioned by SMCs in the presence of insulin. The increased accumulation of PAI-1 in conditioned medium was secondary to both an increased transport of PAI-1 from the basal to the apical surface of ECs as well as an increased production of PAI-1 by ECs. Conclusions Insulin augments arterial expression of PAI-1 by stimulating release of a soluble factor(s) from SMCs. Accordingly, increased arterial elaboration of PAI-1 in response to insulin is likely to account, in part, for the elevated PAI-1 observed in the blood of subjects with insulin-resistant states.
Case of Poisoning by Chloral Hydrate
Authors: W. J. Hunt, R. W. Watkins
Journal: BMJ (1871)

THE BRITI-SH MEDICAL _OURNAL.193 whereas the very opposite to this is the generally admitted fact.Hemorrhage to any extent short of causing exhaustion and prostration is, in my experience, and I believe also in the experience of most observers, rather salutary than otherwise, tending to relieve the patient,
Sodium retention and hypertension with short dialysis.
Authors: L Sellars, V Robson, R Wilkinson
Journal: BMJ (1979)

Exchangeable sodium was measured in 26 patients undergoing dialysis with a modestly shortened schedule of 14.8 hours weekly and related to blood-pressure control. The group was compared with 27 patients studied in 1969 during twice-weekly dialysis totalling 22 hours, and with 18 patients studied in 1973 during dialysis of 18--21 hours weekly in three sessions. Exchangeable sodium was significantly increased with short dialysis compared with the other schedules and, although mean blood pressure was not significantly increased, significantly more patients required antihypertensive treatment than in either 1969 or 1973. A trend towards more frequent resort to bilateral nephrectomy than in 1973 did not reach significance. Problems of hypertension and the side effects of its treatment, both medical and surgical, should be weighed against the social and economic advantages of short dialysis in deciding on the ideal schedule.
Irradiation of Gastric Cancer
Authors: D. Chamberlain
Journal: BMJ (1947)

The standard recoarnended now is a solution of 79.4 mg. of pure crystalline haemin (8.57% iron) or an equivalent amount of another crystalline haemin of lesser iron content (for example 81 mg. of a haemin of 8.41% iron: 794x857 = 81), 8.41 dissolved in 100 ml. of Sorensen's sodium borate buffer pH 9.4,* kept for two days in the ice-box and then diluted to 1 litre with the same borate buffer. (Equivalent to 100% of Haden normal; 15.6 g. haemoglobin per 100 ml. of blood.)Gibson and Harrison (Biochem.J., 1945, 39, v, 490) have recently described an artificial standard consisting of a sul- phuric acid solution of potassium dichromate, chromium sul- phate, and cobalt sulphate.It has been found very satisfactory in this laboratory.It is apparently permanent and the colour is almost identical with that of alkaline haematin solutions formed by treating haemoglobin with sodium hydroxide.-I am, etc.,
Galactorrhea-Amenorrhea, Brom-Ergocryptine, and the Dopamine Receptor
Authors: A.E. Boyd, Seymour Reichlin
Journal: New England Journal of Medicine (1975)

Inappropriate secretion of prolactin is now recognized as one of the important causes of galactorrhea of diverse origin, including that seen after disruption of the portal circulation connecting the hypothalamus and the pituitary, after administration of certain drugs, including birth-control pills, after pregnancy, in some patients with chromophobe pituitary tumors and in women with no clinically detectable disease of pituitary or hypothalamus. Patients with hyperprolactinemia usually have amenorrhea as well. This complication occurs most often because the high prolactin levels interfere either with the secretion of hypothalamic luteinizing hormone-releasing hormone (LH-RH) or with the direct effects of the gonadotrophins on . . .
Origin of Margarine
Authors: H. F. Cascorbi
Journal: JAMA (1971)

To the Editor.—  I have been interested in the history of bread spreads for some time and I am delighted to see a scholarly and thoroughly researched article on bread spreads ( 214 :2312, 1970).  It may be of interest to the readers ofThe Journalto receive information on the origin of the use of margarine 1 : In brief, it was initiated as an economy measure by Abbott Francis Geschmiertsparer (1645 to 1712?) of the Order of St. Benedict in Benedictbeuren, Bavaria.  The first, although somewhat illegible, report was found in one of the monastery's food lists, which states in 1701: Unschlitt and Fischoel, 12 Fass (lard and fish oil, 12 barrels). On pursuing this matter I discovered the following: The monks were required to attend prayer in 1690 (to about 1712, when this practice was changed) for at least 14 hours a day. Consequently, they developed the habit of
Transbronchial needle aspiration in clinical practice.
Authors: E M Harrow, F A Oldenburg, A M Smith
Journal: Thorax (1985)

Transbronchial needle aspiration has recently been adapted for use with the flexible bronchoscope. We studied 108 patients, who had a total of 110 aspirations performed, and diagnosed thoracic cancer in 70 cases. Transbronchial needle aspiration revealed malignant disease in 32 (46%) of these 70 patients. In 12 (17%) patients with cancer this technique provided the sole cytological or histological confirmation of the diagnosis. It gave a positive result in an additional 20 (29%) cases in which the diagnosis was also proved by conventional procedures, and it provided important staging information in these patients. In 20% of patients with cancer transbronchial needle aspiration precluded the need for further diagnostic surgery. There were no complications in this series. This is a safe, useful, and economical technique that can be used in diagnosing and staging patients with carcinoma of the lung.