Are Corticosteroids Beneficial as Adjunctive Therapy for Pneumocystis Pneumonia in AIDS?
Authors: Joseph A. Kovacs
Journal: Annals of Internal Medicine (1990)

Editorials1 July 1990Are Corticosteroids Beneficial as Adjunctive Therapy for Pneumocystis Pneumonia in AIDS?Joseph A. Kovacs, MD, Henry Masur, MDJoseph A. Kovacs, MDSearch for more papers by this author, Henry Masur, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite recent advances in prevention,Pneumocystis cariniipneumonia remains a frequent complication in patients infected with the human immunodeficiency virus (HIV). Many patients, especially the growing numbers from lower socioeconomic groups, are unaware of their HIV-infected status until a major manifestation like pneumocystis pneumonia occurs. Other patients, despite being aware of their HIV infection, fail to take antiretroviral therapy and antipneumocystis prophylaxis regularly because of drug toxicity or economic and psychosocial issues. Even while receiving zidovudine therapy alone, patients with a previous history ofP. cariniipneumonia have a relapse rate of approximately 60% within 1 year if they do...References1. Fischl M. The safety and efficacy of two doses of zidovudine in the treatment of patients with AIDS [Abstract 3606]. Program and Abstracts: IV International Conference on AIDS. Stockholm International Fairs, Stockholm, Sweden, June 12-16, 1988. Google Scholar2. BrennerOgnibeneLack MFE. Prognostic factors and life expectancy of patients with acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia. Am Rev Respir Dis. 1987;136:1199-206. CrossrefMedlineGoogle Scholar3. MasurLaneKovacsAllegraEdman HHJCJ. Pneumocystis pneumonia: from bench to clinic. Ann Intern Med. 1989;111:813-26. 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Corticosteroids as adjunctive therapy in treatment of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. Lancet. 1987;1:1477-9. CrossrefMedlineGoogle Scholar13. GillLoureiroBernstein-SingerRarickSattlerLevine PCMMFA. Clinical effect of glucocorticoids on Kaposi sarcoma related to the acquired immunodeficiency syndrome (AIDS). Ann Intern Med. 1989;110:937-40. LinkGoogle Scholar14. ClementEdisonTurner MRR. Corticosteroids as adjunctive therapy in severe Pneumocystis carinii pneumonia. A prospective, placebo-controlled trial [Abstract]. Am Rev Respir Dis. 1989;139:A250. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The National Institutes of Health Bethesda, MD 20892 Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySteroids for Acute Respiratory Distress Syndrome?Abdominal Aortic AneurysmsAction of Deferoxamine against Pneumocystis cariniiAIDS-related Pneumocystis carinii Pneumonia in the Era of Adjunctive SteroidsDecreasing Frequency But Worsening Mortality of Acute Respiratory Failure Secondary to AIDS-Related Pneumocystis carinii PneumoniaPneumocystis carinii pneumonia in cancer patientsLeukotriene B4 and lnterleukin-8 in Human Immunodeficiency Virus-related Pulmonary DiseaseGlucocorticoids Synergize with Tumor Necrosis Factor α in the Induction of HIV Expression from a Chronically Infected Promonocytic Cell LineRecent Advances in Pulmonary MedicineAdjuvant Corticosteroid Therapy for Pneumocystis Carinii Pneumonia in Aids PatientsCorticosteroids for Pneumocystis carinii Pneumonia with Acute Respiratory FailureDrug Information Analysis ServiceEflornithine Treatment of Refractory Pneumocystis carinii Pneumonia in Patients with Acquired Immunodeficiency SyndromeAerosol Pentamidine for Secondary Prophylaxis of AIDS-related Pneumocystis carinii Pneumonia A Randomized, Placebo-Controlled StudyJulio S. G. Montaner, MD, Lindsay M. Lawson, MD, André Gervais, MD, Robert H. Hyland, MD, Charles K. Chan, MD, Julian M. Falutz, MD, Paolo M. Renzi, MD, Douglas MacFadden, MD, Anita R. Rachlis, MD, I. W. Fong, MD, Gary E. Garber, MD, Andrew Simor, MD, Norbert Gilmore, MD, Mary Fanning, MD, Geoffrey D. Taylor, MD, Alain Y. Martel, MD, Walter F. Schlech, MD, Martin T. Schechter, MD, PhDAfter Five Trials, Consensus Panel Offers RecommendationsClinical management of the complications of HIV infectionPneumocystis carinii pneumonia: the pathogen, the diagnosis and recent advances in managementCorticosteroids for Pneumocystis PneumoniaGregory R. Mason, MDMedical Authorship: Traditions, Trends, and TribulationsW. Bruce Fye, MD, MA 1 July 1990Volume 113, Issue 1Page: 1-3KeywordsAdverse reactionsAntiretroviral therapyCorticosteroid therapyHIVHIV infectionsHIV preventionPneumocystisPneumocystis carinii pneumoniaPneumoniaProphylaxis Issue Published: 1 July 1990 PDF downloadLoading ...