Lidocaine and Psychotic Reactions
Authors: WAYNE M. TURNER
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 July 1982Lidocaine and Psychotic ReactionsWAYNE M. TURNER, PHARM.D.WAYNE M. TURNER, PHARM.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-1-149_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Lidocaine is widely used by injection and for local application to mucous membranes. It is also given intravenously to control ventricular arrhythmias. The main systemic toxic effect, excitation of the central nervous system, is manifested by yawning, restlessness, excitement, nervousness, dizziness, blurred vision, nausea and vomiting, muscle twitching, and convulsions (1). The literature contains only four references to apparent "psychotic" reactions associated with the use of lidocaine (2-5). One patient, reported in Reference 5, is the 48-year-old woman also described here.The adverse drug reaction files of the Food and Drug Administration Division of Drug Experience contain...References1. WADE A. Martindale—The Extra Pharmacopoeia. 27th ed. London: The Pharmaceutical Press; 1978:857. Google Scholar2. ILYASOWENSKVASNICKA MDG. Delirium induced by a combination of antiarrhythmic drugs [Letter]. Lancet. 1969;2:1368. CrossrefMedlineGoogle Scholar3. SELDONSOSAHARA RA. Central nervous system toxicity induced by lidocaine. JAMA. 1967;202:908. CrossrefMedlineGoogle Scholar4. GOLDMAN J. A rare toxic effect of local anesthesia with lidocaine. Br J Anesth. 1958;30:377. CrossrefMedlineGoogle Scholar5. GRAHAMTURNERJONES CWJ. Lidocaine-propranol interactions [Letter]. N Engl J Med. 1981;304:1301. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNeurological complications of cardiovascular drugsPsychotic mania associated with topical ketamine in a patient with thoracic spine injuryNeuropsychiatric Side-Effects of Lidocaine: Examples from the Treatment of Headache and a ReviewIs euphoria a side-effect of lidocaine?An unusual case of emergence deliriumProcainamide-Induced Psychosis: A Case Report and Review of the LiteratureHoigné's syndrome: A procaine-induced limbic kindlingLidocaine in Outpatient Surgery: Central Nervous System Toxicity Manifested by Doom AnxietyZentralnervöse Nebenwirkungen verschiedener antibakterieller SubstanzenA brief psychotic reaction during the administration of intravenous 2-chloroprocaine for the treatment of chronic painDelusions Induced by Procaine Penicillin: Case Report and Review of the SyndromeNeurological complications of cardiovascular therapyDrug-Induced Psychiatric Disorders and their ManagementDysarthria and visual hallucinations due to flecainide toxicity.Local Anaesthetic DrugsParanoid psychosis induced by tocainide. 1 July 1982Volume 97, Issue 1Page: 149-150KeywordsAdverse reactionsCentral nervous systemConvulsionsDrug administrationFood and Drug AdministrationMucous membranesMusclesNauseaVisionVomiting Issue Published: 1 July 1982 PDF DownloadLoading ...