tbuckley/cabot-search huggingface dataset:
Care for Pulmonary Edema
Authors: ROBERT B. COOPER
Journal: Annals of Internal Medicine (1977)

Letters and Corrections1 July 1977Care for Pulmonary EdemaROBERT B. COOPER, M.D.ROBERT B. COOPER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-1-120_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The editorial note "Emergency Management of Acute Pulmonary Edema" (Ann Intern Med 84:488, 1976) explores the relative merits of some recent pharmacologic approaches to cardiogenic pulmonary edema, and the authors state that "morphine and oxygen . . . are still central in the management of acute pulmonary edema secondary to left ventricular failure." This editorial, like most recent discussions of this topic, tends to minimize the less "technical" aspects of treating this disorder.During medical residency I learned that patient positioning is as important as any other single therapeutic maneuver. I observed that a number of patients...Reference1. LEVINE S: Some harmful effects of recumbency in the treatment of heart disease. JAMA 126:80-84, 1944 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Colorado Medical Center Denver, CO 80220 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1977Volume 87, Issue 1Page: 120-120KeywordsEdemaMorphineOxygenResidency Issue Published: 1 July 1977 PDF DownloadLoading ...
Abstract 304: Reactive oxygen species induce prostate cancer cells via activation of the IL6/STAT3 pathway.
Authors: Yi Qu, Runhui Liu, Jigang Zhang, Mihaela Popa, Yaping Hua, Biaoyang Lin, Emmet McCormack, Weidong Zhang, Anne Margrete Oyan, Karl-Henning Kalland, Xisong Ke
Journal: Cancer Research (2013)

Abstract Background: Previously we have established a stepwise prostate carcinogenesis model including human primary prostate epithelial EP156T cells, non-malignant mesenchymal EPT1 cells and pre-malignant EPT2-D5 cells. Aims and methods: To further achieve malignant cells, EPT2-D5 cells were grown in protein-free medium and the tumorigenesis was tested in vivo. Results: 1) Lots of spheres were generated in monolayer culture of D5 cells in protein free medium. The sphere forming cells were named D5HS. 2) Different from EPT2-D5 cells, D5HS formed large subcutaneous tumors (EPT3) and metastasis (EPT3M) in SCID mice. 3) Gene expression profiling showed inflammation signatures in D5HS. 4) Cellular Reactive Oxygen Species Detection Assay (DCFDA) showed high reactive oxygen species (ROS) in D5HS, and ELISA and Western blotting showed high secreted IL6 and high STAT3 expression in D5HS. 5) Blocking of ROS or STAT3 signaling reduced the sphere formation. 6) Immunohistochemistry staining showed high pSTAT3 level in the EPT3 tumor. Conclusions: Reactive oxygen species induce prostate cancer cells via activation of the IL6/STAT3 pathway. Citation Format: Yi Qu, Runhui Liu, Jigang Zhang, Mihaela Popa, Yaping Hua, Biaoyang Lin, Emmet McCormack, Weidong Zhang, Anne Margrete Oyan, Karl-Henning Kalland, Xisong Ke. Reactive oxygen species induce prostate cancer cells via activation of the IL6/STAT3 pathway. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 304. doi:10.1158/1538-7445.AM2013-304
Multicentre study using strain delay index for predicting response to cardiac resynchronization therapy (MUSIC study)
Authors: Pascal Lim, Erwan Donal, Stéphane Lafitte, Genevieve Derumeaux, Gilbert Habib, Patricia Réant, Sophie Thivolet, Nicolas Lellouche, Richard A. Grimm, Pascal Gueret
Journal: European Journal of Heart Failure (2011)
In Memoriam, Dr. Abhijit Guha, 1957-2011
Authors: J. T. Rutka
Journal: Neuro-Oncology (2011)

D r. Abhijit (Ab) Guha passed away peacefully in the early morning hours of November 8, 2011.For 3 years, Ab had been courageously fighting his diagnosis of acute myeloblastic leukemia (AML).He was 54 years old.Ab and I were close friends.We trained in neurosurgery together; we took our neurosurgery exams together; we became interested in neuro-oncology research at the same time; and together, we laid the groundwork for the Arthur and Sonia Labatt Brain Tumour Research Centre.Throughout his illness, during which he endured multiple rounds of chemotherapy, two matched stem cell transplants, numerous bone marrow biopsies, and myriad treatment-related complications, I never heard him complain or think negatively of what life had brought upon him.He soldiered on with his research work, his research grant and manuscript writing, and his mentoring of myriad talented students and accomplished more in those 3 years of his illness than most of us do in a lifetime.
Revalidation will need good appraisal summaries
Authors: M. Muminovic
Journal: BMJ (2002)

The General Medical Council this week told doctors what type of evidence they would need to provide for their appraisals to ensure that the documentation was sufficient for revalidation.

The council's appraisal implementation group found that appraisal folders that contained a comprehensive summary document were often good enough for revalidation, without reference to the underpinning evidence.

But most summaries in the council's …
Outcomes of Acute Phase Cognitive Therapy in Outpatients with Anxious versus Nonanxious Depression
Authors: Jasper A.J. Smits, Abu Minhajuddin, Michael E. Thase, Robin B. Jarrett
Journal: Psychotherapy and Psychosomatics (2012)

Compared to nonanxious depressed patients, anxious depressed patients respond less to pharmacotherapy, prompting consideration of alternate treatments. Based on the transdiagnostic principles of cognitive therapy (CT), we predicted that anxious depressed patients would respond as well to CT as nonanxious depressed patients.Adults (n = 523) with recurrent major depressive disorder received 12-14 weeks of CT as part of the Continuation Phase Cognitive Therapy Relapse Prevention Trial. Anxious depressed patients (n = 264; 50.4%) were compared to nonanxious depressed patients (n = 259; 49.6%) on demographic variables, initial severity, attrition, and rates and patterns of response and remission.Anxious depressed patients presented with greater illness severity and had significantly lower response (55.3 vs. 68.3%) and remission rates (26.9 vs. 40.2%) based on clinician-administered measures. By contrast, smaller between-group differences for attrition, and for response (59.1 vs. 64.9%) and remission (41.7 vs. 48.7%) rates on self-report measures were not significant. Further, anxious depressed patients had greater speed of improvement on self-reported anxiety symptom severity and clinician-rated depressive and anxiety symptom severity measures.Consistent with prior reports, anxious depressed patients presented with greater severity and, following CT, had lower response and remission rates on clinician-administered scales. However, anxious depressed patients improved more rapidly and response and remission rates on self-report measures were not significantly different from nonanxious depressed patients. Our findings suggest that anxious depressed patients may simply need additional time or more CT sessions to reach outcomes fully comparable to those of less anxious patients.
How Is the Medical Student Being Trained in Microbiology and Infections?
Authors: HAROLD C. NEU
Journal: Annals of Internal Medicine (1978)

Reduction in curriculum time and shifts in interests of microbiology and epidemiology departments have altered the nature of the exposure of medical students to clinical problems of microbiology and infectious diseases. Major objectives of training in microbiology and infectious diseases are poorly met because of the large mass of material the student needs to assimilate. Students graduate from medical school using antimicrobial agents as a substitute for diagnostic acumen, without an understanding of how microbiologic laboratories should be used. Methods to improve this situation should be studied.
Histologic Subtype of Metastatic Renal Cell Carcinoma Predicts Response to Combined Immunochemotherapy with Interleukin 2, Interferon α and 5-Fluorouracil
Authors: Edwin Herrmann, Olaf Anselm Brinkmann, Marc-Eric Bode, Stefan Bierer, Thomas Köpke, Martin Bögemann, Lothar Hertle, Christian Wülfing
Journal: European Urology (2006)
Clinical Usefulness of the Endoscopic Video Capsule in Patients with Obscure Gastrointestinal Bleeding
Authors: R. Dalla Valle, F. Fornaroli, N. de’Angelis, B. Bizzarri, G. L. de’Angelis
Journal: Endoscopy (2005)

We read the paper by Delvaux et al. [1] with interest. The study confirms the value of capsule endoscopy in the diagnosis of obscure gastrointestinal bleeding, and in this context also shows that capsule endoscopy is capable of identifying lesions that have not been detected in previous upper and lower endoscopies (10 nonneoplastic gastric and/or colonic lesions in 44 reported cases).
Toward Electronic Medical Record Alerts That Consume Less Physician Time—Reply
Authors: Hardeep Singh, Dean F. Sittig
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Cilomilast, tacrolimus and rapamycin modulate dendritic cell function in the elicitation phase of allergic contact dermatitis
Authors: W. Baumer, B. Sulzle, H. Weigt, V.C. De Vries, M. Hecht, T. Tschernig, M. Kietzmann
Journal: British Journal of Dermatology (2005)

Cilomilast and tacrolimus as well as rapamycin are potential drugs for the treatment of allergic skin diseases like atopic dermatitis and allergic contact dermatitis.To compare the in vitro and in vivo immunomodulatory effects of the phosphodiesterase 4 inhibitor cilomilast with those of tacrolimus and rapamycin.The in vitro action of cilomilast, tacrolimus and rapamycin were tested in a mixed leucocyte reaction (MLR). In vivo, the inhibitory action of the immunomodulatory drugs was compared in the toluene-2,4-diisocyanate (TDI)-induced allergic inflammatory response with particular focus on dendritic cell (DC) function.Cilomilast, tacrolimus and rapamycin were all able to inhibit DC-mediated T-cell activation in a MLR. But it was demonstrated for cilomilast that the target cells are T cells rather than DC. In vivo, a combination of systemic and topical administration of each of these three substances significantly inhibited swelling in the murine ear 16 h after TDI challenge. There was also a reduction in the weight of the draining auricular lymph node, in lymphocyte cell count, and in the number of emigrated DC. The density of Langerhans cells in the epidermis was correspondingly higher in mice treated with cilomilast, tacrolimus and rapamycin than in those treated with vehicle. All three substances were found to inhibit DC migration ex vivo in a skin DC migration assay performed on ear tissue after TDI challenge.DC migration into the draining lymph node also takes place in the elicitation phase of allergic contact dermatitis and this migration can be influenced by tacrolimus and rapamycin, and, to a lesser extent, by cilomilast.
Kidney Function After Off-Pump or On-Pump Coronary Artery Bypass Graft Surgery
Authors: Amit X. Garg, P. J. Devereaux, Salim Yusuf, Meaghan S. Cuerden, Chirag R. Parikh, Steven G. Coca, Michael Walsh, Richard Novick, Richard J. Cook, Anil R. Jain, Xiangbin Pan, Nicolas Noiseux, Karel Vik, Noedir A. Stolf, Andrew Ritchie, Roberto R. Favaloro, Sirish Parvathaneni, Richard P. Whitlock, Yongning Ou, Mitzi Lawrence, Andre Lamy
Journal: JAMA (2014)

Most acute kidney injury observed in the hospital is defined by sudden mild or moderate increases in the serum creatinine concentration, which may persist for several days. Such acute kidney injury is associated with lower long-term kidney function. However, it has not been demonstrated that an intervention that reduces the risk of such acute kidney injury better preserves long-term kidney function.To characterize the risk of acute kidney injury with an intervention in a randomized clinical trial and to determine if there is a difference between the 2 treatment groups in kidney function 1 year later.The Coronary Artery Bypass Grafting Surgery Off- or On-pump Revascularisation Study (CORONARY) enrolled 4752 patients undergoing first isolated coronary artery bypass graft (CABG) surgery at 79 sites in 19 countries. Patients were randomized to receive CABG surgery either with a beating-heart technique (off-pump) or with cardiopulmonary bypass (on-pump). From January 2010 to November 2011, 2932 patients (from 63 sites in 16 countries) from CORONARY were enrolled into a kidney function substudy to record serum creatinine concentrations during the postoperative period and at 1 year. The last 1-year serum creatinine concentration was recorded on January 18, 2013.Acute kidney injury within 30 days of surgery (≥50% increase in serum creatinine concentration from prerandomization concentration) and loss of kidney function at 1 year (≥20% loss in estimated glomerular filtration rate from prerandomization level).Off-pump (n = 1472) vs on-pump (n = 1460) CABG surgery reduced the risk of acute kidney injury (17.5% vs 20.8%, respectively; relative risk, 0.83 [95% CI, 0.72-0.97], P = .01); however, there was no significant difference between the 2 groups in the loss of kidney function at 1 year (17.1% vs 15.3%, respectively; relative risk, 1.10 [95% CI, 0.95-1.29], P = .23). Results were consistent with multiple alternate continuous and categorical definitions of acute kidney injury or kidney function loss, and in the subgroup with baseline chronic kidney disease.Use of off-pump compared with on-pump CABG surgery reduced the risk of postoperative acute kidney injury, without evidence of better preserved kidney function with off-pump CABG surgery at 1 year. In this setting, an intervention that reduced the risk of mild to moderate acute kidney injury did not alter longer-term kidney function.clinicaltrials.gov Identifier: NCT00463294.
SAFETY OF REGADENOSON AS A PHARMACOLOGIC STRESS AGENT FOR MYOCARDIAL PERFUSION IMAGING IN STAGE 3, 4 AND 5 CHRONIC KIDNEY DISEASE PATIENTS NOT ON HEMODIALYSIS
Authors: Karthikeyan Ananthasubramaniam, Gurunanthan Palani, Zehra Husain, Aarthee Karthikeyan, Vanji Karthikeyan
Journal: Journal of the American College of Cardiology (2010)
Hepatitis B Virus Load in Serum Does Not Reflect Histologic Activity in Patients With Decompensated Cirrhosis
Authors: Jin Dong Kim, Jong Young Choi, Si Hyun Bae, Seung Kew Yoon, Jin Mo Yang, Nam Ik Han, Sang Wook Choi, Chang Don Lee, Young Sok Lee, Eun Sun Jung
Journal: Clinical Gastroenterology and Hepatology (2009)
Conditional Transgene Expression in the Heart
Authors: Zhihui Yu, Charles S. Redfern, Glenn I. Fishman
Journal: Circulation Research (1996)

Conditional transgene expression is a potentially useful approach to investigate complex biological systems in vivo. We recently demonstrated that tetracycline-responsive promoters could be employed to achieve regulated, cardiac-specific expression of target genes in transgenic mice. To more fully define the quantitative and spatial parameters associated with tetracycline-regulated gene expression in the heart, we crossed transgenic mice harboring either a firefly luciferase or a nuclear-localized bacterial lacZ target gene with strains expressing a tetracycline-controlled transactivator (tTA) under the regulatory control of 2.9 kb of 5′ flanking sequence from the rat α-myosin heavy chain gene. Luciferase activity was induced nearly 300-fold in the hearts of binary-transgenic mice compared with mice carrying only the luciferase reporter gene. No significant transactivation was observed in any other tissues examined. Binary transgenics harboring the lacZ reporter gene showed substantial β-galactosidase activity throughout the heart, but the response of individual cardiac myocytes was heterogeneous. For both reporter genes, tetracycline treatment fully repressed tTA-dependent transactivation. These data provide important insights into the nature of studies that can be successfully addressed using the tetracycline-regulated gene expression system in the heart.
How Far Along Are You?
Authors: Jane deLima Thomas
Journal: Annals of Internal Medicine (2007)

On Being a Doctor20 November 2007How Far Along Are You?Jane deLima Thomas, MDJane deLima Thomas, MDFrom Dana Farber Cancer Institute, Boston, MA 02115.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-10-200711200-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I took a deep breath before entering Mrs. Bell's room. I had not yet met this patient, and her nurse told me there were many concerned family members and church friends gathered at the bedside. I knew that Mrs. Bell's adult children were having difficulty coming to terms with the course of their mother's uterine cancer. She was dying, and her family and friends had come to pray and say goodbye. My role as a palliative care fellow was to try to make sure she was comfortable, and to help her loved ones through this time, to the extent they ... Author, Article, and Disclosure InformationAffiliations: From Dana Farber Cancer Institute, Boston, MA 02115.Corresponding Author: Jane deLima Thomas, MD, Dana Farber Cancer Institute, 44 Binney Street, G411, Boston, MA 02115; e-mail, [email protected]org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 November 2007Volume 147, Issue 10Page: 738KeywordsChildrenEmotionsMorphineNursesPalliative carePregnancySleepToxinsUterine cancerVeins ePublished: 20 November 2007 Issue Published: 20 November 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
FURTHER OBSERVATIONS UPON FOOT-AND-MOUTH DISEASE IN ITS RELATION TO HUMAN SCARLATINA AS A PROPHYLACTIC.Read in the Section of Diseases of Children at the Forty-first Annual Meeting of the American Medical Association, at Nashville, Tenn., May, 1890.
Authors: J. W. STICKLER
Journal: JAMA (1890)

On December 1, 1887, a paper upon the above subject was read in the presence of, and discussed by, the New York Academy of Medicine. Since that time I have obtained from Dr. M. K. Robinson, of Dover, England, additional statistics which he has secured for me at considerable personal inconvenience, and which are, I think, of sufficient interest, to quote in connection with what has already appeared in relation to the matter under consideration. First, let me review enough of my former paper, to present clearly the subject as we are now to consider it. During the early days of February, 1884, a remarkable outbreak of sore throat occurred in Dover, England, which was due to the drinking of milk obtained from cows affected with foot-and-mouth disease. During the week ending February 9, 205 persons were attacked with the disease. "The majority of persons who
Conceptualizing Administrative Databases as Screening Tools for Health System Quality
Authors: David C. Chang, Christopher Evans, Joseph Parker
Journal: JAMA Surgery (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Induced Hypertension in the Treatment of Severe Ischemia of the Foot
Authors: VIGGO HANSTEEN, EINAR LORENTSEN
Journal: Circulation (1972)

The present paper reports the results of angiotensin infusion in 11 patients with severe atherosclerosis of the lower limbs adding a brief discussion of indications with inherent dangers and contraindications. The study confirms the results of Dahn et al. 4,5 that pharmacologically induced hypertension may increase distal perfusion pressure and flow and relieve resting pains. It is our opinion, however, that only a very limited number of patients presenting with severe foot ischemia and resting pains can profit from this treatment because of frequent contraindications such as coexistent hypertension and coronary heart disease.
GP acted "irresponsibly" when treating 18 patients with painkillers
Authors: C. Dyer
Journal: BMJ (2010)

Howard Martin, a retired GP who was acquitted of murdering three of his patients in the north of England in 2005, is facing charges at the General Medical Council of “irresponsibly” giving potentially fatal doses of painkilling drugs to 18 terminally ill patients.

The hearing at Manchester, which is expected to last until 18 June, is going ahead in the absence of Dr Martin, 75, and without legal representation for him.

A GMC spokeswoman said the Medical Defence Union had told the council that he …