Beta Adrenergic Blockade for Prophylaxis Against Recurrent Myocardial Infarction and Sudden Death
Authors: JOHN ROSS
Journal: Annals of Internal Medicine (1976)

Editorials1 April 1976Beta Adrenergic Blockade for Prophylaxis Against Recurrent Myocardial Infarction and Sudden DeathJOHN ROSS JR., M.D., F.A.C.P.JOHN ROSS JR., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-4-486 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe findings of a multicenter study in which the beta adrenergic blocking agent practolol was used for prophylaxis against recurrent myocardial infarction and sudden death in a large, randomized clinical trial were reported recently in theBritish Medical Journal(1). The results appear to have important implications for the management of patients after myocardial infarction. Indeed, the authors conclude that "Patients should receive longterm beta adrenoreceptor blocking treatment after anterior myocardial infarction unless specific contraindications exist . . . to be initiated between a few days and a month after the infarct" (1). No firm recommendations were made for routine...References1. : Improvement in prognosis of myocardial infarction by long-term beta-adrenoreceptor blockade using practolol. Br Med J 3:735-740, 1975 CrossrefMedlineGoogle Scholar2. CRAWFORDLEWINTERO'ROURKE MMR: Combined propranolol and digoxin therapy in angina pectoris. Ann Intern Med 83:449-455, 1975 LinkGoogle Scholar3. PANTRIDGEWEBBADGEY JSA: The first hour after the onset of acute myocardial infarction, in Progress in Cardiology, vol. 3, edited by HU PN, GOODWIN JF. Philadelphia, Lea & Febiger, 1974 Google Scholar4. MAROKOKJEKSHUSSOBEL PJB: Factors influencing infarct size following experimental coronary artery occlusion. Circulation 43:67-82, 1971 CrossrefMedlineGoogle Scholar5. THEROUXROSSFRANKLIN PJD: Regional myocardial function in the conscious dog during acute coronary occlusion and responses to morphine, propranolol, nitroglycerin, and lidocaine. Circulation 53:302-314, 1976 CrossrefMedlineGoogle Scholar6. THEROUXFRANKLINROSS PDJ: Regional myocardial function during acute coronary artery occlusion and its modification by pharmacologic agents in the dog. Circ Res 35:896-908, 1974 CrossrefMedlineGoogle Scholar7. VERRIERTHOMPSONLOWN RPB: Ventricular vulnerability during sympathetic stimulation: role of heart rate and blood pressure. Cardiovasc Res 8:602-610, 1974 CrossrefMedlineGoogle Scholar8. BLOOREHSANIWHITE CAF: Ventricular fibrillation threshold in acute myocardial infarction and its relation to myocardial infarct size. Cardiovasc Res 9:468-472, 1975 CrossrefMedlineGoogle Scholar9. KENTSMITHREDWOOD KED: Electrical stability of acutely ischemic myocardium. Influences of heart rate and vagal stimulation. Circulation 47:291-298, 1973 CrossrefMedlineGoogle Scholar10. WEBBADGEYPANTRIDGE SAJ: Autonomic disturbance at onset of acute myocardial infarction. Br Med J 3:89-92, 1972 CrossrefMedlineGoogle Scholar11. LIEWELLENSDOWNAR KHE: Observations on patients with primary ventricular fibrillation complicating acute myocardial infarction. Circulation 52:755-759, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN ROSSJR., M.D., F.A.C.P.Affiliations: Department of Medicine University of California San Diego La Jolla, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Wohlfahrtseffekte von OptionsmärktenPropranololAntihypertensive TherapieTherapeutic Aspects of HypertensionTherapeutische Aspekte der HypertonieIsolated left anterior descending coronary artery disease: Choice of therapy 1 April 1976Volume 84, Issue 4Page: 486-487KeywordsClinical trial reportingMyocardial infarctionProphylaxis ePublished: 1 December 2008 Issue Published: 1 April 1976 PDF downloadLoading ...