Translation of Genetic Discoveries into Clinical Therapies
Authors: Daniel G. Hackam, Abigail S. Hackam
Journal: Annals of Internal Medicine (2008)

Letters5 February 2008Translation of Genetic Discoveries into Clinical TherapiesDaniel G. Hackam, MD, PhD and Abigail S. Hackam, BSc, PhDDaniel G. Hackam, MD, PhDFrom the University of Western Ontario, London, Ontario N6G 2V2, Canada, and Bascom Palmer Eye Institute, University of Miami, Miami, FL 33136.Search for more papers by this author and Abigail S. Hackam, BSc, PhDFrom the University of Western Ontario, London, Ontario N6G 2V2, Canada, and Bascom Palmer Eye Institute, University of Miami, Miami, FL 33136.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-3-200802050-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Discovering the genetic basis for human disease is thought to be a key step in the search for new treatments.Objective: To examine the rate at which genetic discoveries translate into randomized trials and approved treatment options, focusing on highly cited genetic research, because such visible work is generally more likely to be tested in the clinical domain (1, 2).Methods: To identify genetic discoveries, we used Web of Science to search all genetic, medical, and biological journals that publish genetic research and have a citation impact factor of 5 or greater (3). 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Hackam was supported by a Research for the Prevention of Blindness Career Development Award, the International Retinal Research Foundation, the Karl Kirchgessner Foundation, and a grant-in-aid from Fight for Sight Foundation. Institutional support was provided by an unrestricted grant to Bascom Palmer Eye Institute from the Research to Prevent Blindness and a National Eye Institute core grant (P30 EY014801).Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInappropriate modeling of chronic and complex disorders: How to reconsider the approach in the context of predictive, preventive and personalized medicine, and translational medicineForum 5 February 2008Volume 148, Issue 3Page: 246-247KeywordsClinical geneticsClinical trialsDatabasesFellowshipsGenetic determinismGenetic diseasesGeneticsHuman geneticsRandomized trialsSystematic reviews ePublished: 5 February 2008 Issue Published: 5 February 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...