tbuckley/cabot-search huggingface dataset:
The Effect of Intravenous Trypsin Administration on the Electrocardiogram of the Rabbit
Authors: JERROLD S. LIEBERMAN, ALEXANDER TAYLOR, IRVING S. WRIGHT
Journal: Circulation (1954)

The intravenous injection of trypsin into rabbits resulted in marked changes in the rhythm and alteration in the P, QRS, S-T and T deflections of the electrocardiogram.
THE TREATMENT OF INCIPIENT PHTHISIS
Authors: W. Gordon
Journal: BMJ (1923)

<b>Objective:</b> To compare familial inflammatory inclusion body myositis (IBM) with hereditary inclusion body myopathies and sporadic IBM. <b>Patients and methods:</b> Clinical, biological, MRI, and histological data were analysed in two siblings with inflammatory IBM and compared with those of patients with sporadic and hereditary IBM. <b>Results:</b> Both patients had a clinical phenotype of sporadic IBM, which differs from hereditary myopathies because of late age of onset—respectively 65 and 66 years, and different pattern of muscular involvement—asymmetric, mainly distal but also involving quadriceps. MRI showed selective fatty infiltration and oedema in the extensor compartment of thigh muscles. The diagnosis of IBM was confirmed by muscle biopsy, showing muscle fibres containing numerous rimmed vacuoles, a characteristic shared by all types of IBM. In contrast with hereditary IBM, histological analysis also showed inflammatory mononuclear infiltrate invading non-necrotic fibres, ragged red and oxidase c negative fibres, and positive Congo red staining. Moreover, HLA class II typing disclosed DRβ1 0301 haplotype, which is significantly related to sporadic but not to hereditary IBM. With steroid treatment and monthly intravenous immunoglobulins, the disease was stabilised in both patients at protracted follow up. <b>Conclusion:</b> Sporadic and familial inflammatory IBM share the same clinical, biological, MRI, and histological features.
Novel X-linked glomerulopathy is associated with a COL4A5 missense mutation in a non-collagenous interruption
Authors: Brian Becknell, Gloria A. Zender, Ronald Houston, Peter B. Baker, Kim L. McBride, Wentian Luo, David S. Hains, Dorin-Bogdan Borza, Andrew L. Schwaderer
Journal: Kidney International (2010)
Hospital Prospective Payment and the Quality of Care
Authors: Bruce C. Vladeck
Journal: New England Journal of Medicine (1988)

Even before the advent of the Medicare prospective payment system (PPS) on October 1, 1983, concern was expressed that this new payment method would affect adversely the quality of hospital care given to Medicare beneficiaries. The use of diagnosis-related groups as the basis for payment would, it was argued, encourage hospitals to reduce the lengths of inpatient stay excessively and to provide inadequate service.The period immediately following the inception of PPS was filled with reports of patients being discharged from hospitals "quicker and sicker" and with anecdotes describing particularly egregious cases. Congressional hearings and governmental investigations followed, along with . . .
Right Heart Catheterization and Cardiac Complications in Patients Undergoing Noncardiac Surgery
Authors: Carisi A. Polanczyk
Journal: JAMA (2001)

ContextRight heart catheterization (RHC) is commonly performed before high-risk noncardiac surgery, but the benefit of this strategy remains unproven.ObjectiveTo evaluate the relationship between use of perioperative RHC and postoperative cardiac complication rates in patients undergoing major noncardiac surgery.DesignProspective, observational cohort study.SettingTertiary care teaching hospital in the United States.PatientsPatients (n = 4059 aged ≥50 years) who underwent major elective noncardiac procedures with an expected length of stay of 2 or more days between July 18, 1989, and February 28, 1994. Two hundred twenty one patients had RHC and 3838 did not.Main Outcome MeasureCombined end point of major postoperative cardiac events, including myocardial infarction, unstable angina, cardiogenic pulmonary edema, ventricular fibrillation, documented ventricular tachycardia or primary cardiac arrest, and sustained complete heart block, classified by a reviewer blinded to preoperative data.ResultsMajor cardiac events occurred in 171 patients (4.2%). Patients who underwent perioperative RHC had a 3-fold increase in incidence of major postoperative cardiac events (34 [15.4%] vs 137 [3.6%]; P&lt;.001). In multivariate analyses, the adjusted odds ratios (ORs) for postoperative major cardiac and noncardiac events in patients undergoing RHC were 2.0 (95% confidence interval [CI], 1.3-3.2) and 2.1 (95% CI, 1.2-3.5), respectively. In a case-control analysis of a subset of 215 matched pairs of patients who did and did not undergo RHC, adjusted for propensity of RHC and type of procedure, patients who underwent perioperative RHC also had increased risk of postoperative congestive heart failure (OR, 2.9; 95% CI, 1.4-6.2) and major noncardiac events (OR, 2.2; 95% CI, 1.4-4.9).ConclusionsNo evidence was found of reduction in complication rates associated with use of perioperative RHC in this population. Because of the morbidity and the high costs associated with RHC, the impact of this intervention in perioperative care should be evaluated in randomized trials.
The Endocrinology and Developmental Biology of the Prostate*
Authors: GERALD R. CUNHA, ANNEMARIE A. DONJACOUR, PAUL S. COOKE, HSARRON MEE, ROBERT M. BIGSBY, STEPHEN J. HIGGINS, YOSHIKI SUGIMURA
Journal: Endocrine Reviews (1987)

MALE accessory sex glands such as the prostate, seminal vesicle, and bulbourethral gland have served in various capacities as models for investigating the action of androgens in regulating epithelial growth, RNA and protein synthesis, and secretory activity. The most extensively studied gland of this group is the prostate. This gland is found exclusively in mammals and produces many components of semen such as fructose, zinc ions, and various proteins important for the formation of the copulatory plug in rodents. The impetus for investigating regulation of prostatic growth and function stems in part from the many pathological complications which affect this gland. The prostate is the site of various types of inflammatory and infectious conditions (1) as well as benign and malignant proliferative changes in aging males. Despite extensive research, little of the pathogenesis or natural history of these diseases has been elucidated (2). Benign prostatic hypertrophy (BPH), a disease in which the prostate resumes growth late in life, is the most common nonmalignant proliferative abnormality found in any internal organ (2). The incidence of BPH rises from 23% in men at 40 yr of age to 88% by the ninth decade (3). Adenocarcinoma of the prostate is the third leading cause of cancer deaths among men. Approximately 69 cases/100,000 men are diagnosed each year in the United States. It remains an intriguing paradox that malignant prostatic tumors are among the most prevalent neoplasms in men, while the seminal vesicles and bubulbourethral gland remain nearly immune to neoplastic change (<1 case of carcinoma of the seminal vesicle per year) (4).
Hemodynamic effects of dobutamine in patients following open heart surgery.
Authors: T Sakamoto, T Yamada
Journal: Circulation (1977)

Dobutamine, a new synthetic inotropic agent, was administered by intravenous infusion to 22 patients following open heart surgery. The dosage of dobutamine started from 2 mug/kg/min and was increased stepwise to 4, 6, and 8 mug/kg/min. Cardiac index increased from 2.54 +/- 0.13 to 3.11 +/- 0.19 and 3.50 +/- 0.22 L/min/m2 with 4 and 8 mug/kg/min, respectively. Heart rate increased from 87.6 +/- 2.9 to 96.4 +/- 2.3 and 108.9 +/- 3.2 beats/min with 4 and 8 mug/kg/min, respectively. Systolic and mean aortic pressure and systolic pulmonary arterial pressure were elevated from 126.0 +/- 3.8 to 144.6 +/- 6.0 mm Hg, from 91.8 +/- 2.7 to 96.2 +/- 3.2 mm Hg, and from 33.4 +/- 2.3 to 37.1 +/- 2.5 mm Hg with 8 mug/kg/min, while other pressures were unchanged. Mean left atrial pressure fell significantly from 15.9 +/- 0.6 to 14.8 +/- 0.7 mm Hg. Stroke volume index, stroke work index, and left ventricular work also increased. Premature ventricular beats were observed in only one patient during dobutamine infusion, but no other side effect was observed. We conclude that dobutamine is a potent inotropic agent which increases cardiac output without causing significant tachycardia or arrhythmias, and is useful for the treatment of patients following open heart surgery.
High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders
Authors: J. Pablo Abonia, Ting Wen, Emily M. Stucke, Tommie Grotjan, Molly S. Griffith, Katherine A. Kemme, Margaret H. Collins, Philip E. Putnam, James P. Franciosi, Karl F. von Tiehl, Brad T. Tinkle, Keith A. Marsolo, Lisa J. Martin, Stephanie M. Ware, Marc E. Rothenberg
Journal: Journal of Allergy and Clinical Immunology (2013)
Impaired primary T cell responses in L-selectin-deficient mice.
Authors: J Xu, I S Grewal, G P Geba, R A Flavell
Journal: The Journal of Experimental Medicine (1996)

L-selectin is a homing receptor that mediates the selective attachment of leukocytes to specialized high endothelial venules. To study the potential role of L-selectin in immune responses in intact mice, we generated L-selectin-deficient mice by gene targeting. L-selectin-deficient mice are defective in cutaneous delayed-type hypersensitivity (DTH) responses when tested after conventional intervals of immunization (4 d). Primary T cell proliferative responses and cytokine production (interleukin [IL] 2, IL-4, and interferon gamma) were also compromised when tested after 5 d of immunization, indicating that L-selectin is important for the immune response to antigens. In contrast, after more prolonged immunization protocols (9 d), normal responses were observed, suggesting that L-selectin-independent compensatory mechanisms exist. Interestingly, humoral responses of L-selectin-deficient mice to keyhole limpet hemocyanin are indistinguishable from wild-type control mice, implying that L-selectin plays no rate-limiting role in T cell help of B cell function. Thus, our results suggest that L-selectin plays an important role in the generation of primary T cell responses but may not be essential for humoral and memory T cell responses. L-selectin does not appear to be rate limiting for the events leading to antigen-driven neutrophil recruitment, since normal DTH responses are obtained at late time points after immunization.
WALDEMAR HAFFKINE, C.I.E
Authors: W. J. Simpson
Journal: BMJ (1930)

BY the death of Professor Haffkinie tllele lhas passedl away, at tlde age of 70, a great scientist, whose researches eniabled himi to produce first a cholera and later a plague pr-ophylactic vaccinie hIiclh are now effectively used wherever tlhee is an outbreak of cholera or plague.His nlamie will always be associated wvith this great achievemenet.T'hie hlistor'y of tlle cliolera prophylactic takes us back to Iofe.ssor Kochl's discovery in Egypt in 1883, when he found commiia bacilli in. the intestines of patienlts Who liad died of cholera, anid in. the rice-water stools of 'patients sufferinig from cholera.Like all iiew discover ies, it was received with suspicion, even after hiis visit to Calcutta, -_ wliwere lie found in the patieiits suffering from cholera the saie miicro-organisms.It was niot unitil lie retur-ned to Germnany andl ani accident occurri ed in Pr ofessor Koch's laboirator y in Ber lin, wiherie r -..
The Influence of Autonomic Vasoregulatory Reflexes on the Rate of Sodium and Water Excretion in Man
Authors: Henry N. Wagner
Journal: Journal of Clinical Investigation (1957)

Patient B. B. Time: 8:40, Inulin prime; then 20 mg. per minute inulin infusion in 5 per cent glucose at 1 ml per minute.t Inulin clearance.Sodium and potassium excretion in microequivalents per minute.Urine osmola ity.Total solute excretion in microosmoles per minute.* Clearance of total solute.tt Solute-free water clearance.
B-Vitamin Therapy for Diabetic Nephropathy
Authors: Iefke Drion
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dendritic cells with lymphocyte-stimulating activity differentiate from human CD133 positive precursors
Authors: Maria Ida Bonetti, Laura Pieri, Lola Domenici, Serena Urbani, Giovanni Romano, Alessandra Aldinucci, Clara Ballerini, Monica Monici, Riccardo Saccardi, Venere Basile, Alberto Bosi, Paolo Romagnoli
Journal: Blood (2011)
Twin pregnancy with complete hydatidiform mole (46,XX) and fetus (46,XY): genetic origin proved by analysis of chromosome polymorphisms.
Authors: R A Fisher, D M Sheppard, S D Lawler
Journal: BMJ (1982)

In a case of complete hydatidiform mole with fetus the genetic origins were defined by the use of chromosomal polymorphisms. The fetus had a normal 46,XY karyotype with evidence of the presence of both maternal and paternal chromosomes. The mole was 46,XX and of androgenetic origin. There was no evidence of a maternal contribution, and duplication of paternal chromosomes was shown. In such atypical molar pregnancies examining genetic polymorphisms yields much more information than do sex chromosome studies and karyotyping, particularly in confirming the diagnosis and defining the origin and aetiology of the condition.
Concomitant Hepatitis B Surface Antigen and Antibody in Thirteen Patients
Authors: P. GREGORY FOUTCH
Journal: Annals of Internal Medicine (1983)

Both hepatitis B surface antigen (HBsAg) and its antibody (anti-HBs) were found in 13 patients. Nine patients had HBsAg subtype ad, and 7 had anti-HBs monotypic subtype anti-y. Nine patients had HBsAg before detectable levels of anti-HBs were present. Of the 6 patients whose serum contained subtypes of both HBsAg and anti-HBs, 4 had HBsAg before development of the monotypic antibody. All patients have remained positive for HBsAg and anti-HBs (mean duration, 55.5 weeks). Nine patients were positive for HBeAg, and 7 had renal disease. Six of these seven patients are on hemodialysis. Because of the differing subtype specificities of the circulating HBsAg and anti-HBs, we conclude that HBsAg and anti-HBs occur concomitantly. The presence of HBeAg, which indicates infectivity, is common in our study group, suggesting that these patients are a reservoir for transmission of hepatitis-B-virus infection. Therefore, the presence of anti-HBs alone does not indicate a noninfectious serum. Concomitant HBsAg and anti-HBs seems to be particularly common in patients with renal disease who are on hemodialysis.
'Obesity many disorders;' causes sought in genes, neurochemistry, psychology
Authors: C. A. Raymond
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sperm Morphology, Motility, and Concentration in Fertile and Infertile Men
Authors: David S. Guzick, James W. Overstreet, Pam Factor-Litvak, Charlene K. Brazil, Steven T. Nakajima, Christos Coutifaris, Sandra Ann Carson, Pauline Cisneros, Michael P. Steinkampf, Joseph A. Hill, Dong Xu, Donna L. Vogel
Journal: New England Journal of Medicine (2001)

Although semen analysis is routinely used to evaluate the male partner in infertile couples, sperm measurements that discriminate between fertile and infertile men are not well defined.
Self-Reported Truck Traffic on the Street of Residence and Symptoms of Asthma and Allergic Disease: A Global Relationship in ISAAC Phase 3
Authors: Bert Brunekreef, Alistair W. Stewart, H. Ross Anderson, Christopher K.W. Lai, David P. Strachan, Neil Pearce
Journal: Environmental Health Perspectives (2009)

BackgroundAssociations between traffic pollution on the street of residence and a range of respiratory and allergic outcomes in children have been reported in developed countries, but little is known about such associations in developing countries.MethodsThe third phase of the International Study of Asthma and Allergies in Childhood (ISAAC) was carried out in 13- to 14-year-old and 6- to 7-year-old children across the world. A question about frequency of truck traffic on the street of residence was included in an additional questionnaire. We investigated the association between self-reported truck traffic on the street of residence and symptoms of asthma, rhinoconjunctivitis, and eczema with logistic regression. Adjustments were made for sex, region of the world, language, gross national income, and 10 other subject-specific covariates.ResultsFrequency of truck traffic on the street of residence was positively associated with the prevalence of symptoms of asthma, rhinoconjunctivitis, and eczema with an exposure–response relationship. Odds ratios (95% confidence intervals) for "current wheeze" and "almost the whole day" versus "never" truck traffic were 1.35 (1.23–1.49) for 13- to 14-year-olds and 1.35 (1.22–1.48) for 6- to 7-year-olds.ConclusionsHigher exposure to self-reported truck traffic on the street of residence is associated with increased reports of symptoms of asthma, rhinitis, and eczema in many locations in the world. These findings require further investigation in view of increasing exposure of the world's children to traffic.
GMC clears psychiatrist accused of encouraging "false memories"
Authors: O. Dyer
Journal: BMJ (2003)

A child psychiatrist accused of encouraging a 13 year old girl to develop false memories of being abused by another doctor has been cleared of serious professional misconduct by the General Medical Council.

Dr John William Eastgate, a consultant at Princess Margaret's Hospital in Swindon, told police and child services of his concerns without consulting the girl's parents. The girl, referred to as Miss A, later made accusations to child services against three other men, including her father. None were substantiated. Miss A's family later complained to the GMC.

Miss A saw Dr …
Oncogenic NOTCH1 Control of MYC and PI3K: Challenges and Opportunities for Anti-NOTCH1 Therapy in T-Cell Acute Lymphoblastic Leukemias and Lymphomas
Authors: Teresa Palomero, Adolfo Ferrando
Journal: Clinical Cancer Research (2008)

The identification of activating mutations in NOTCH1 in the majority of T-cell acute lymphoblastic leukemias and lymphomas (T-ALL) has brought much interest in inhibiting NOTCH1 signaling as therapeutic target in this disease. Small-molecule inhibitors of the gamma-secretase complex, which mediates a critical proteolytic cleavage required for NOTCH1 activation, hold the promise of becoming an effective molecular therapy against relapsed and refractory T-ALL. Recent progress in the elucidation of the transcriptional regulatory networks downstream of oncogenic NOTCH1 has uncovered a central role of NOTCH1 signaling in promoting leukemic cell growth and revealed an intricate circuitry that connects NOTCH1 signaling with MYC and the PI3K-AKT signaling pathway. The identification of the downstream effector pathways controlled by NOTCH1 should pave the way for the rational design of anti-NOTCH1 therapies for the treatment of T-ALL.
microRNAs become macro players in somatic cell reprogramming
Authors: Tamer T Onder, George Q Daley
Journal: Genome Medicine (2011)

Embryonic stem cell specific microRNAs (miRNAs) have previously been shown to enhance the efficiency of transcription-factor-based reprogramming. However, whether reprogramming could be achieved entirely by miRNAs remained unclear. A recent report shows that the expression of the miR-302/367 cluster of miRNAs can directly reprogram somatic cells without the use of any transcription factors. This new method raises interesting questions about the mechanisms of reprogramming and is likely to facilitate the generation of induced pluripotent stem cells for potential future clinical use.
Latent tuberculosis infection in patients with chronic plaque psoriasis: evidence from the Italian Psocare Registry
Authors: P. Gisondi, S. Cazzaniga, S. Chimenti, M. Maccarone, M. Picardo, G. Girolomoni, L. Naldi
Journal: British Journal of Dermatology (2014)

Background The nationwide prevalence of latent tuberculosis infection (LTBI) in Italian patients with psoriasis has never been investigated. Objectives To estimate the nationwide prevalence of LTBI in Italian patients with psoriasis who are candidates for systemic treatment. Methods Data were obtained from the Psocare Registry on those patients (n = 4946) with age > 18 years, systemic treatment at entry specified and tuberculin skin test (TST) performed according to the Mantoux method. LTBI diagnosis was based on a positive TST result in the absence of any clinical, radiological or microbiological evidence of active tuberculosis. Results Latent tuberculosis infection was diagnosed in 8·3% of patients with psoriasis (409 of 4946). The prevalence of LTBI was lower in patients on biologics than in those on conventional systemic treatments, ranging from 4·3% (19 of 444) of patients on adalimumab to 31% (eight of 26) of those on psoralen–ultraviolet A (P < 0·05). Independent factors associated with LTBI were male sex [odds ratio (OR) 1·30, 95% confidence interval (CI) 1·04–1·62; P = 0·02], age over 55 years (OR 2·93, 95% CI 2·18–3·93; P < 0·001) and being entered into a conventional treatment (OR 3·83, 95% CI 3·10–4·74; P < 0·001). Positive history of tuberculosis was seen in 1% of patients (n = 49). Conclusions The nationwide prevalence of LTBI in Italian patients with psoriasis candidate to systemic treatment is high, and screening is recommended prior to biological treatment.