Capecitabine Induces Severe Angina-Like Chest Pain
Authors: Isa E.L.M. Kuppens, Henk Boot, Jos H. Beijnen, Jan H.M. Schellens, Jerry Labadie
Journal: Annals of Internal Medicine (2004)

Letters16 March 2004Capecitabine Induces Severe Angina-Like Chest PainIsa E.L.M. Kuppens, PharmD, Henk Boot, MD, PhD, Jos H. Beijnen, PharmD, PhD, Jan H.M. Schellens, MD, PhD, and Jerry Labadie, MDIsa E.L.M. Kuppens, PharmDFrom The Netherlands Cancer Institute, 1066 CX Amsterdam, and LAREB, 5237 MH 'sHertogenbosch, the Netherlands., Henk Boot, MD, PhDFrom The Netherlands Cancer Institute, 1066 CX Amsterdam, and LAREB, 5237 MH 'sHertogenbosch, the Netherlands., Jos H. Beijnen, PharmD, PhDFrom The Netherlands Cancer Institute, 1066 CX Amsterdam, and LAREB, 5237 MH 'sHertogenbosch, the Netherlands., Jan H.M. Schellens, MD, PhDFrom The Netherlands Cancer Institute, 1066 CX Amsterdam, and LAREB, 5237 MH 'sHertogenbosch, the Netherlands., and Jerry Labadie, MDFrom The Netherlands Cancer Institute, 1066 CX Amsterdam, and LAREB, 5237 MH 'sHertogenbosch, the Netherlands.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-6-200403160-00034 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: The cardiovascular side effects of fluoropyrimidines have been extensively reported (1). However, cardiotoxicity associated with capecitabine, a novel oral fluoropyrimidine prodrug increasingly used in advanced breast, colorectal, and gastric cancer, has been infrequently described.Objective: To describe 3 cases of severe angina-like chest pain possibly or probably related to capecitabine treatment. These cases were reported to the Netherlands Pharmacovigilance Centre.Case Reports: Patient 1, a 44-year-old woman in good clinical condition, was receiving chemotherapy for advanced ovarian cancer. When her disease progressed, she was treated with 1500 mg of capecitabine twice daily. On the third day ...References1. Becker K, Erckenbrecht JF, Haussinger D, Frieling T. Cardiotoxicity of the antiproliferative compound fluorouracil. Drugs. 1999;57:475-84. [PMID: 10235688] CrossrefMedlineGoogle Scholar2. Pai VB, Nahata MC. Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention. Drug Saf. 2000;22:263-302. [PMID: 10789823] CrossrefMedlineGoogle Scholar3. Bertolini A, Flumano M, Fusco O, Muffatti A, Scarinci A, Pontiggia G, et al . Acute cardiotoxicity during capecitabine treatment: a case report. Tumori. 2001;87:200-6. [PMID: 11504378] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From The Netherlands Cancer Institute, 1066 CX Amsterdam, and LAREB, 5237 MH 'sHertogenbosch, the Netherlands. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRechallenge capecitabine after fluoropyrimidine-induced cardiotoxicity in rectal cancerCardiac arrest and ventricular fibrillation in a young man treated with capecitabine: Case report and literature reviewCapecitabine-induced ventricular fibrillation arrest: Possible Kounis syndromeAcute presentation of vasospastic angina induced by oral capecitabine: a case reportCapecitabine-Induced Chest Pain Relieved by DiltiazemKounis syndrome is likely culprit of coronary vasospasm induced by capecitabineInitial dose effect of 5-fluorouracil: rapidly improving severe, acute toxic myopericarditisAnticancer therapy induced cardiotoxicity: review of the literatureCapecitabine-induced cardiotoxicity mimicking myocardial infarctionSíndrome coronario agudo durante la monoterapia oral con capecitabinaCapecitabine in the treatment of advanced gastric cancerAcute Coronary Syndrome During Oral Capecitabine MonotherapyCapecitabineCapecitabine-Induced Headache Responding to DiltiazemAcute Coronary Syndrome Induced by Capecitabine TherapyCardiac and cardiovascular toxicity of nonanthracycline anticancer drugsAcute coronary syndrome induced by oral capecitabineCardiotoxicity of Cancer TherapyCommon Etiology of Capecitabine and Fluorouracil-Induced Coronary Vasospasm in a Colon Cancer Patient 16 March 2004Volume 140, Issue 6Page: 494-495KeywordsAnginaChemotherapyColorectal cancerDatabasesDrugsElectrocardiographyIschemiaOdds ratioTroponinUltrasound imaging ePublished: 16 March 2004 Issue Published: 16 March 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...