tbuckley/cabot-search huggingface dataset:
Practical Cardiology: Evaluation and Management of Common Cardiovascular Disorders
Authors: Arthur C. Fox
Journal: Annals of Internal Medicine (2003)

Medical Writings: Book Notes5 August 2003Practical Cardiology: Evaluation and Management of Common Cardiovascular DisordersArthur C. Fox, MDArthur C. Fox, MDNew York University School of Medicine, New York, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-3-200308050-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Eagle KA and Baliga RR, eds. 688 pages. Philadelphia; Lippincott Williams & Wilkins; 2003. $59.95. ISBN 0781732611. Order phone 800-638-3030.Field of medicine: Cardiology.Format: Softcover book.Audience: Practitioners involved primarily in preventive and general care of patients with cardiovascular disease.Purpose: To provide a user-friendly but authoritative source of information on how to diagnose, manage, or treat patients with cardiovascular disease.Content: Section 1 is a basic outline of how to evaluate patients with symptoms commonly caused by cardiovascular disease. Section 2, the most comprehensive section, deals with evaluation and management of major cardiovascular conditions. Section 3 discusses anticoagulation, ... Author, Article, and Disclosure InformationAffiliations: New York University School of Medicine, New York, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 August 2003Volume 139, Issue 3Page: 236KeywordsCardiac surgeryCardiovascular diseasesCardiovascular therapyHeartMitral insufficiencyPatientsPulmonary hypertensionRisk assessmentsSoftware toolsStable coronary artery disease ePublished: 5 August 2003 Issue Published: 5 August 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Tests for cancer.
Authors: R C Jennings, D Brocklehurst, M Hirst, A Ziros
Journal: BMJ (1969)

Cyclone over Cyclamates SIR,-In your leading article (1 November, p. 251) you point out that the decision to ban the manufacture of cyclamates has been taken without evidence that they cause disease in man, whereas the production of cigarettes, which are known to be highly dangerous, is less severely censored.A curtailed consumption of cyclamates lnight well lead to a compensatory increase i-i the consumption of sugar, for which they are a substitute.Whereas cyclamates have produced no proved ill-effects in man, exces- sive sugar consumption is believed by many to be a major factor in the causation of much disease, including diabetes,`13 coronary dis- ease,35 dental caries,6 and obesity.Almost anything taken in gross excess is harmful.Would the replacement of cyclamates by sugar not be tantamount to recommending a therapeutic procedure carrying a 10% mortality to treat a disease having a 1 %/b mortality ?-I am, etc.,
Points from Letters: Referendum
Authors: J. E. Hodgkin
Journal: BMJ (1970)

BITISH(often in his prime) rather than take the risk of a breakdown in health in the sub- sequent five years.Compare the lot of the man who gets an award, say, at 50.Not only can he afford to ease off earlier, he can also spare the time to attend clinical meetings, administrative committees, and write papers, and in due course this bears the fruit of an even higher award.Although the system is supposedly
THE FIRST SUCCESSFUL CASE OF CÆSAREAN SECTION IN PLACENTA PRÆVIA, AND REMARKS ON THE METHOD OF OPERATION.
Authors: AUGUSTUS CHARLES BERNAYS
Journal: JAMA (1894)

<i>History of the Case and Literature</i>.On Nov. 19, 1893, at 2 P.M. I was called to see Mrs. A. M., by her physicians, Drs. R. J. O'Reilly and W. W. Graves. The message calling me stated that I was wanted in order to perform the CÆsarean section and that the case was one of placenta prÆvia centralis. The patient is a healthy woman, 42 years of age, mother of four living children, the youngest a boy 10 years old. Dr. O'Reilly had been engaged to attend her in confinement which he had calculated would take place about the middle of December. He had been called by the husband at 1:30 a.m. cm account of an alarming hemorrhage and arriving a few minutes later found the patient excited and frightened by the unexpected hemorrhage, sitting in a chair and a large bundle of cloths under her saturated with blood. The os
Subcutaneous Nodules on the Fingers—Quiz Case
Authors: Pamela A. Morganroth, Marsha L. Chaffins, Henry W. Lim
Journal: JAMA Dermatology (2013)

A 52-year-old black man presented with 2 slowly enlarging, mildly painful subcutaneous nodules, one on the left second finger and one on the right fourth finger. His primary care physician had treated the nodules as arthritis with ibuprofen, without improvement.
Disturbance of Calcium Metabolism by Anticonvulsant Drugs
Authors: A. Richens, D. J. F. Rowe
Journal: BMJ (1970)

A survey of calcium metabolism in epileptic patients in a residential centre showed a subnormal serum calcium level in 22.5% of patients and a raised alkaline phosphatase in 29%. Hypocalcaemia was related to high dosage of anticonvulsant drugs, to multiple drug therapy, and to the use of individual anticonvulsant drugs in the following order, with decreasing order of importance: pheneturide, primidone, phenytoin, phenobarbitone. Subnormal serum calcium levels occurred more commonly in patients with a raised liver alkaline phosphatase isoenzyme than in those whose phosphatase was mainly of bone origin.Preliminary results of treatment with calciferol suggested that the disturbance of calcium metabolism was the result of vitamin D deficiency. It is possible that anticonvulsant drugs accelerate the breakdown of vitamin D by liver enzyme induction.
Abstract 5258: Overexpressed TYRO3 in colorectal cancer regulates tumorigenesis and metastasis
Authors: Chun Wei Chien, Yen-Yu Lai, Bo-Wen Lin, Shao-Chieh Lin, Jenq-Chang Lee, Shaw-Jenq Tsai
Journal: Cancer Research (2014)

Abstract Colon cancer is a multiple-step disease with less 10% survival rate at late stage. To achieve improvement of colon cancer therapy, we aim to find novel oncogenes that contribute to colon cancer progression. By our in-house bioinformatic tool prediction, we identified TYRO3 to be a potential oncogene. TYRO3, a receptor tyrosine kinase, was reported to be overexpressed in melanoma via genomic screening; however, its role in cancer initiation, progression, and malignancy remains largely unknown. Herein, we showed that compared to normal colon tissue, TYRO3 is overexpressed in polyps and colon cancer tissue. The expression level in colon cancer is significantly associated with cancer malignancy. Overexpression of TYRO3 increased cell proliferation, motility, and anchorage-independent colony formation in vitro. Furthermore, we confirmed TYRO3 tumorigenic potential by xenograft model and metastatic assay in vivo. To investigate novel mechanisms mediated by TYRO3, we performed next generation sequencing (RNS-seq) to identify genes that were upregulated under TYRO3 overexpression. Results showed that TYRO3 significantly enriched genes involved in epithelial-mesenchymal transition and tumorigenesis, which is consistent with our hypothesis and finding. Taken together, these data provide evidence to support that TYRO3 plays an important role in malignant process of colon cancer progression likely through its novel functions in the nucleus. Citation Format: Chun Wei Chien, Yen-Yu Lai, Bo-Wen Lin, Shao-Chieh Lin, Jenq-Chang Lee, Shaw-Jenq Tsai. Overexpressed TYRO3 in colorectal cancer regulates tumorigenesis and metastasis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5258. doi:10.1158/1538-7445.AM2014-5258
1097. Complete and Persistent Phenotypic Correction of Phenylketonuria in Mice by Site-Specific Genome Integration of Phenylalanine Hydorxylase cDNA
Authors: Li Chen, Savio L.C. Woo
Journal: Molecular Therapy (2005)

Top of pageAbstract
Phenylketonuria (PKU) is a metabolic disorder that predisposes affected children to severe and irreversible mental retardation, and is secondary to a deficiency of the hepatic enzyme phenylalanine hydroxylase (PAH), that catalyses the conversion of phenylalanine to tyrosine. In an attempt to correct this metabolic deficiency, we explored the potential of using a bacteriophage integrase system to achieve site-specific genome integration of murine PAH cDNA in the livers of Phenylketonuric mice. The integrase from Streptomyces phage |[Phi]|BT1 mediates efficient recombination between the phage attachment site attP and the bacterial attachment site attB, results in the integration of phage DNA into the bacterial genome in a site-specific manner. Here we showed that this phage enzyme functioned efficiently both in Escherichia coli and mouse cells in vitro. Several naturally occurring |[ldquo]|pseudo|[rdquo]| attP sites in the mouse genome, which contain partial sequence identity to the wild type attP site and are recognizable by the phage integrase, have been identified and molecularly characterized. In the presence of the phage integrase, naked plasmid DNA containing a wild-type attB site can be integrated specifically into these pseudo attP site permanently both in culture mouse cells and in the livers of mice. We further demonstrated that the addition of nuclear localization signal sequences to the C-terminus of the phage integrase enzyme enhanced the efficiency for transgene integration into the mouse genome. Using this phage integration system we delivered mouse PAH cDNA to the livers of PKU mice by hydrodynamic injection of plasmid DNA and showed that serum phenylalanine levels in the treated mice decreased significantly and persistently. After 3 applications, serum phenylalanine levels in all treated mice were reduced to the normal range and remained stable for more than 6 weeks. Furthermore, their fur color also changed from gray to black, indicating the reconstitution of melatonin biosynthesis as a result of available tyrosine derived from phenylalanine hydroxylation. Thus the bacterio-phage integrase represents an effective site-specific genome integration system in mammalian cells and can be of great value in plasmid DNA-mediated gene therapy of a multitude of genetic disorders.
In vitro differentiation of endothelial cells from AC133-positive progenitor cells
Authors: Ursula M. Gehling, Süleyman Ergün, Udo Schumacher, Christoph Wagener, Klaus Pantel, Marcus Otte, Gunter Schuch, Philippe Schafhausen, Thorsten Mende, Nerbil Kilic, Katrin Kluge, Birgit Schäfer, Dieter K. Hossfeld, Walter Fiedler
Journal: Blood (2000)
EFFECTS OF PROTEIN MASS ON THE PHARMACOKINETICS OF MONOCLONAL ANTIBODIES (MoAb)
Authors: Gerald L. DeNardo, Sally J. DeNardo, Jo-Sen Peng, Lois F. O??Grady, Stanley L. Mills, Robert C. Cardiff
Journal: Clinical Nuclear Medicine (1984)

MoAb can be labeled with I-123 at high specific activities, so that only small amounts of protein are required for injection of large amounts of radioactivity for radioimmunoimaging or radioimmunotherapy. This can conserve antibody and decrease the possibilities of foreign protein reactions and target tissue binding site saturation. However, some investigators have suggested the use of milligram quantities of MoAb. In order to assess the effects on pharmacokinetics and imaging, we have administered microgram or milligram amounts of MoAb on separate occasions to 2 patients with a target tumor and 2 patients without a target tumor. Pharmacokinetics were observed in blood and urine by counting whole samples and HPLC fractions of these samples and in organs by serial imaging. Blood clearance and urinary excretion were faster during the early hours after injection of microgram amounts of MoAb, but subsequently were comparable to those obtained after milligram amounts. HPLC revealed rapid accumulation of radioiodide in the blood after microgram amounts, whereas the rate of accumulation and amount of radioiodide were less after milligram amounts. Complexes occurred earlier after milligram and later after microgram amounts of MoAb. Images confirmed rapid clearance of accumulation in stomach, thyroid and bladder. When a target cancer was present, there was also relatively greater activity in the lungs with microgram MoAb amounts compared to milligram amounts. This was not true in the absence of a target cancer. These observations have significant, but as yet, incompletely clear implications for radioimmunoimaging and radioimmunotherapy.
The Art of JAMA: One Hundred Covers and Essays From The Journal of the American Medical Association
Authors: Stefan C. Schatzki
Journal: JAMA (1997)

The<i>JAMA</i>art covers, with their accompanying insightful essays by Dr M. Therese Southgate, are a familiar weekly treat for most physicians. It is thus a particular pleasure to review Dr Southgate's recent book, which reprints 100 covers and their associated essays, originally published between 1974 and 1987. For more than two decades, Dr Southgate has chosen the art for over 1000<i>JAMA</i>covers and provided physicians a comprehensive survey of Western art. From a 15th-century painting by Fra Angelico to a 1981 work by Andrew Wyeth, these 100 works cover a wide spectrum of American and European art. While most of the artists in this volume are well known, and some of the individual works quite famous, such as<i>The Gross Clinic</i>, by Thomas Eakins, and<i>The Doctor</i>, by Sir Luke Fildes, other paintings and painters, like<i>The Chinese Fishmonger</i>, by Theodore Wores, and<i>First Aid</i>, by Francis W.
ACUTE EPIDEMIC POLIOMYELITIS COMPLICATING PREGNANCY
Authors: M. BERNARD BRAHDY
Journal: JAMA (1933)

The occurrence of epidemic poliomyelitis during pregnancy raises several questions. How often does it occur? Should the patient go to term and, if she does, what will be the effect on the labor? Will a viable infant be born? If so, what are the probabilities of intra-uterine infection? There is no unanimity of opinion as to the frequency of poliomyelitis occurring during pregnancy, nor as to the susceptibility of gravid women to the disease. Aycock<sup>1</sup>believes that poliomyelitis occurs more frequently in the latter part of pregnancy than would normally be expected if the condition had not predisposed to the disease. Jungeblut and Engle<sup>2</sup>state that early pregnancy and early infancy are the high-water marks of natural resistance to poliomyelitis. The same authors examined the blood of ten women at various stages of pregnancy and found an apparently higher individual virucidal titer than is commonly found in normal
Cancer Research in the United States
Authors: O. M. Ray, R. G. Meader
Journal: CA A Cancer Journal for Clinicians (1957)

The purpose of this article is to review for practicing physicians recent develop ments in cancer research.Space does not permit a detailed discussion of any of the many aspects of the general problem nor does it allow acknowledgement of the many investigators whose work will be mentioned.Inasmuch as neither of the authors has been engaged in investigative work for some years, it is to be understood that they take no credit for the
Changes in anemia management and hemoglobin levels following revision of a bundling policy to incorporate recombinant human erythropoietin
Authors: Takeshi Hasegawa, Jennifer L. Bragg-Gresham, Ronald L. Pisoni, Bruce M. Robinson, Shunichi Fukuhara, Takashi Akiba, Akira Saito, Kiyoshi Kurokawa, Tadao Akizawa
Journal: Kidney International (2010)
Lichen sclerosus et atrophicus in non-identical female twins
Authors: N.H. Cox, J.N.S. Mitchell, W.N. Morley
Journal: British Journal of Dermatology (1986)

Journal Article Lichen sclerosus et atrophicus in non‐identical female twins Get access N.H. Cox, N.H. Cox Department of Dermatology, Royal Hospital for Sick Children, Glasgow, Scotland, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.N.S. Mitchell, J.N.S. Mitchell Vale of Leven District General Hospital, Alexandria, Dumbartonshire, Scotland, U.K. Search for other works by this author on: Oxford Academic Google Scholar W.N. Morley W.N. Morley Department of Dermatology, Royal Hospital for Sick Children, Glasgow, Scotland, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue 6, 1 December 1986, Pages 743–746, https://doi.org/10.1111/j.1365-2133.1986.tb06659.x Published: 01 December 1986
Anaemia of chronic disease in gastroenterology outpatients - scan not scope!
Authors: S. Hazeldine, U. Chelvaratnam, P. D. Thomas, S. Pugh
Journal: Gut (2011)

<h3>Introduction</h3> Patients with anaemia of unknown origin are often referred for gastroenterological investigations. This is commonly due to an anaemia of chronic disease (ACD) as a consequence of an underlying inflammatory or neoplastic process. Referring clinicians are often unfamiliar with the biochemical indices that help distinguish this from iron deficiency anaemia (IDA) and there can be difficulty in establishing a cause in mixed IDA and ACD states. Patients are often frail and unfit for endoscopy. The optimal method for investigating ACD has not been established. We aimed to study a group of patients with ACD referred to gastroenterology outpatients using contrast CT scanning of the chest, abdomen and pelvis as the primary diagnostic tool. <h3>Methods</h3> 53 consecutive patients with ACD referred to gastroenterology outpatients between 1/1/09 and 30/6/10 were identified from a database. All patients met the following criteria: Hb &lt;13 g/dL men and &lt;12 g/dL women, ferritin &gt;30, B12 and folate normal. Patients were assessed clinically by one of 2 clinicians and if deemed fit and had no apparent cause for the anaemia underwent a contrast CT of chest, abdomen and pelvis. <h3>Results</h3> The mean age was 76 (range 53–93), mean Hb 10.1 (6–12.8), MCV 90.3, ferritin 233 (31–1346). 35 patients underwent whole body contrast CT scanning. 18 patients did not undergo CT on the advice of the clinician due to frailty (n = 4), GFR&lt;60 (n = 7), inflammatory conditions thought to explain the ACD. Of the 35 CT examinations, 9 (26%) were normal. 8 (23%) revealed benign non-significant pathology (NSP). 12 (34%) patients had a diagnosis of cancer, none of which were of luminal GI origin (3 renal cell, 3 lung, 1 bladder, 1 adrenal, 1 hepatoma, 1 pancreatic cancer with metastases, 1 prostate cancer with metastases, 1 metastases with unknown primary). 6 (17%) patients had significant ‘benign’ findings, for example, cavitating lung lesion, pulmonary haemorrhage due to vasculitis. Comparison of the 17 patients with normal/NSP and the 18 patients with malignancy or significant benign pathology revealed no significant difference in age (p = 0.5), ferritin (p = 0.1), MCV (p = 0.96), CRP (p = 0.05). <h3>Conclusion</h3> The diagnostic yield for whole body contrast CT in ACD is high with 51% patients having either malignant or significant benign pathology. One third of those assessed had malignancy, most of which was non-gastrointestinal in origin. This compares with an approximate 10% diagnosis of malignancy in patients presenting with IDA. Haematological causes were comparatively rare. Serum indices such as Hb, ferritin and CRP levels could not distinguish between those patients with normal/benign pathology and those with malignancy/significant benign disease. Whole body CT should be the preferred investigation in patients presenting with ACD for which no obvious cause is evident.
Analysis of hepatocellular carcinoma hemodynamics using contrast enhanced ultrasonography with levovist
Authors: Akiko Saito, Koichi Haruyama, Hideki Nozawa, Kenji Hanada, Masami Kikuzato, Koichi Simizu, Satoshi Katagiri, Hideo Katsuragawa, Ken Takasaki, Naoaki Hayashi
Journal: Journal of Hepatology (2002)
Activation of the Cardiac Proteasome During Pressure Overload Promotes Ventricular Hypertrophy
Authors: Christophe Depre, Qian Wang, Lin Yan, Nadia Hedhli, Pallavi Peter, Li Chen, Chull Hong, Luc Hittinger, Bijan Ghaleh, Junichi Sadoshima, Dorothy E. Vatner, Stephen F. Vatner, Kiran Madura
Journal: Circulation (2006)

Background— The adaptation of cardiac mass to hemodynamic overload requires an adaptation of protein turnover, ie, the balance between protein synthesis and degradation. We tested 2 hypotheses: (1) chronic left ventricular hypertrophy (LVH) activates the proteasome system of protein degradation, especially in the myocardium submitted to the highest wall stress, ie, the subendocardium, and (2) the proteasome system is required for the development of LVH. Methods and Results— Gene and protein expression of proteasome subunits and proteasome activity were measured separately from left ventricular subendocardium and subepicardium, right ventricle, and peripheral tissues in a canine model of severe, chronic (2 years) LVH induced by aortic banding and then were compared with controls. Both gene and protein expressions of proteasome subunits were increased in LVH versus control ( P &lt;0.05), which was accompanied by a significant ( P &lt;0.05) increase in proteasome activity. Posttranslational modification of the proteasome was also detected by 2-dimensional gel electrophoresis. These changes were found specifically in left ventricular subendocardium but not in left ventricular subepicardium, right ventricle, or noncardiac tissues from the same animals. In a mouse model of chronic pressure overload, a 50% increase in heart mass and a 2-fold increase in proteasome activity (both P &lt;0.05 versus sham) were induced. In that model, the proteasome inhibitor epoxomicin completely prevented LVH while blocking proteasome activation. Conclusions— The increase in proteasome expression and activity found during chronic pressure overload in myocardium submitted to higher stress is also required for the establishment of LVH.
Obliterative bronchiolitis in rheumatoid arthritis
Authors: W. J. Penny, R. K. Knight, A. M. Rees, A. L. Thomas, A. P. Smith
Journal: Annals of the Rheumatic Diseases (1982)

Two patients with rheumatoid arthritis who developed obliterative bronchiolitis are described. Both patients had received penicillamine. The first patient died in respiratory failure 4 months after the onset of her breathlessness and the diagnosis was confirmed at post-mortem. The second patient was diagnosed with appropriate lung function tests and has been started on azathioprine. Although she is still disabled by breathlessness 12 months after presentation, her condition has stabilised.
Observations on SOME TENDON RUPTURES
Authors: H. Platt
Journal: BMJ (1931)

Tendoni ruptures may be divided into two main groups:(1) The common rupture, produced by the sudden powerful overstretching of a muscle already in a state of contraction.Well-known examples of this type are disinsertion of the extensor tendons of the fingers, and ruptures of the tendo Achillis, rectus femoris, and ligamentum patellae.(2) This comprises a less common and more insidious form of rupture-spontaneous rupture-seen in certain tendons which occupy a bony groove.In these circumstances the rupture is determined by a pre-existing adhesion of the tendon, which gradually becomes attenuated, and ultimately snaps across in response to a comparatively trivial violence.The tendons most liable to rupture by this process of attrition are the extensor longus pollicis and the long head of the biceps.Teildon ruptures may also be classified according to the site of the tear, which may take place (a) at the musculo-tendinous junction, (b) in the tendon itself, or (c) at the point of insertion.Tears in the neighbourhood of the musculo-tendinous junction are almost invariably incomplete, and from a ftunctional standpoint are equivalent to partial tears of the muscle belly-lesions which are usually included under the generic title " strain."This paper is mainly concerned with the problems of early diagnosis and operative repair in some of the more important complete ruptures.The subject is illustrated by references to typical tendon ruptures selected from my own cases.