tbuckley/cabot-search huggingface dataset:
TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer
Authors: Daniel T. Starczynowski, William W. Lockwood, Sophie Deléhouzée, Raj Chari, Joanna Wegrzyn, Megan Fuller, Ming-Sound Tsao, Stephen Lam, Adi F. Gazdar, Wan L. Lam, Aly Karsan
Journal: Journal of Clinical Investigation (2011)

Somatic mutations and copy number alterations (as a result of deletion or amplification of large portions of a chromosome) are major drivers of human lung cancers. Detailed analysis of lung cancer–associated chromosomal amplifications could identify novel oncogenes. By performing an integrative cytogenetic and gene expression analysis of non–small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC) cell lines and tumors, we report here the identification of a frequently recurring amplification at chromosome 11 band p13. Within this region, only TNF receptor–associated factor 6 (TRAF6) exhibited concomitant mRNA overexpression and gene amplification in lung cancers. Inhibition of TRAF6 in human lung cancer cell lines suppressed NF-κB activation, anchorage-independent growth, and tumor formation. In these lung cancer cell lines, RAS required TRAF6 for its oncogenic capabilities. Furthermore, TRAF6 overexpression in NIH3T3 cells resulted in NF-κB activation, anchorage-independent growth, and tumor formation. Our findings show that TRAF6 is an oncogene that is important for RAS-mediated oncogenesis and provide a mechanistic explanation for the previously apparent importance of constitutive NF-κB activation in RAS-driven lung cancers.
SAT0343 Severe prevalent vertebral fractures predict subsequent vertebral and non-vertebral fractures: A 3-year prospective study
Authors: O. Bruyere, C. Roux, D. Nicolet, J. Fechtenbaum, R. Deroisy, J.-Y. Reginster
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> To examine whether a prevalent severe vertebral fracture predicts subsequent fracture and to assess the effect of strontium ranelate to reduce fracture in patients with such prevalent severe vertebral fracture. <h3>Methods</h3> Analysis of two 3-year randomized controlled trials investigating the clinical effect of strontium ranelate. Vertebral and major non-vertebral fractures (i.e. ribs sternum, wrist region, pelvic sacrum, collarbone, humerus, proximal femur) were assessed during the 3 years. At baseline on standard radiographs, each vertebra received a severity grade corresponding to either no fracture either a mild, moderate or severe fracture based on a semi-quantitative visual assessment. All women received calcium and vitamin D during the whole length of the study. <h3>Results</h3> 6137 women aged mean (SD) 75.1 (6.1) years were included in this study. In the placebo group, after 3 years of follow-up, 43% of the women with a prevalent severe vertebral fracture had experienced a new vertebral fracture compared to only 12.5% of the women without any vertebral fracture (OR 3.46 [2.87-4.18]). The logistic regression analysis, adjusted for age, body mass index, femoral neck bone mineral density and number of prevalent vertebral fractures, showed that the presence of a severe vertebral fracture was significantly associated with new vertebral fractures over a 3-year follow-up period. In women with severe prevalent vertebral fracture (N=680), strontium ranelate was able to significantly reduce the risk of new vertebral fractures (OR 0.75 [0.61-0.91]). <h3>Conclusions</h3> In summary, severe prevalent vertebral fracture is an independent predictor of new vertebral and non-vertebral fractures that could be taken into account in fracture risk management. <h3>Disclosure of Interest</h3> O. Bruyere Grant/Research support from: Servier, C. Roux: None Declared, D. Nicolet: None Declared, J. Fechtenbaum: None Declared, R. Deroisy: None Declared, J.-Y. Reginster: None Declared
Physicians' Ethical Obligations Regarding Alternative Medicine
Authors: Jeremy Sugarman
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aneurysm Occurring in the Pancreaticoduodenal Arteries Treated by Excision
Authors: Francis P. Catanzaro, Anthony Merlino, Joseph A. Palumbo
Journal: New England Journal of Medicine (1957)

A NEURYSMS of the superior pancreaticoduodenal artery are extremely rare surgical lesions. In 1952 Sampsel et al.1 reported a case of aneurysm involving an anomalous pancreaticoduodenal artery. This was the first incident of an aneurysm occurring in this location in the American literature. Recently, Hendrick2 presented the first case report of an aneurysm of the superior pancreaticoduodenal artery treated successfully by excision. Since only 2 cases of aneurysm in this location and only 1 treated by excision have previously been described, we consider the second case successfully treated by surgical excision to be worth reporting. Reports have appeared with some . . .
Bad Water Resolved
Authors: Mike Mitka
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Paracetamol hepatotoxicity: A built-in antidote?
Authors: Roger Williams
Journal: Hepatology (1986)

The analgesic effect, toxicity and kinetics of oral paracetamol were compared with those of paracetamol + l-methionine (5:1). The analgesic effect of paracetamol, studied in the Randall-Selitto test in rats, was not changed by methionine: ED50 was 94.6 mg/kg without methionine and 94.1 mg/kg with it. However, methionine reduced the acute toxicity (LD50) of paracetamol by 50% (p < 0.05) in non-fasted, fasted and phenobarbital-pre-treated mice. In a randomized cross-over study in 10 human volunteers the pharmacokinetics of paracetamol (1,500 mg) was not affected by methionine (300 mg). The absorption of methionine from the combination tablets was rapid, peak concentrations occurred in plasma at 30 min and were 3–4 times higher than after paracetamol tablets not containing methionine. Methionine in products containing paracetamol should increase their safety and be the simplest way to reduce the high mortality in paracetamol overdosage.
Effect of Dilantin on Myocardial Uptake of TI-201 Thallous Chloride A Case Report
Authors: STEPHEN E. BUDD, LEE B. PADOVE, JAMES D. HEIRONIMUS
Journal: Clinical Nuclear Medicine (1992)

Dilantin has been reported to decrease myocardial uptake of TI-201 thallous chloride by as much as 38.8% in rats. To date, no studies have been done in humans to document the effect of dilantin on the myocardial uptake of thallium or its effect clinically on the interpretation of images obtained while on dilantin. The authors report a case in which simultaneous exercise echocardiogram and TI-201 myocardial scintigraphy and serial TI-201 myocardial scintigraphy were performed but revealed no adverse effect on image quality or interpretation.
Measles Virus Suppresses RIG-I-like Receptor Activation in Dendritic Cells via DC-SIGN-Mediated Inhibition of PP1 Phosphatases
Authors: Annelies W. Mesman, Esther M. Zijlstra-Willems, Tanja M. Kaptein, Rik L. de Swart, Meredith E. Davis, Martin Ludlow, W. Paul Duprex, Michaela U. Gack, Sonja I. Gringhuis, Teunis B.H. Geijtenbeek
Journal: Cell Host & Microbe (2014)
Serum IgE in Eosinophilic Gastroenteritis
Authors: James H. Caldwell, James I. Tennenbaum, Herbert A. Bronstein
Journal: New England Journal of Medicine (1975)

EOSINOPHILIC gastroenteritis is an uncommon digestive disease. Although it is often regarded as allergic in origin, trials of elimination diet generally have been unsuccessful, and relatively little evidence for an allergic mechanism has been presented. The apparent lack of relation between eosinophilic gastroenteritis and food allergy associated with common atopy contributes to the uncertain role for immediate hypersensitivity in this disorder. Since serum levels of IgE have found wide application in the in vitro assessment of more common forms of allergy — e.g., ragweed sensitivity — we studied serum IgE in two patients with proved eosinophilic gastroenteritis. We sought to . . .
T‐cell acute lymphoblastic leukemia with natural killer cell phenotype
Authors: Joseph Kaplan, Yaddanapudi Ravindranath, Susumu Inoue
Journal: American Journal of Hematology (1986)

Abstract To determine the type and proportion of cases within that type of acute lymphoblastic leukemia (ALL) that has a natural killer (NK) cell phenotype, we examined leukemic blasts from 31 children with ALL (14 with T‐ALL, 17 with non‐T‐ALL) for expression of antigens detected by NK‐specific monoclonal antibodies Leu 11b, Leu 7, and 1G2 (an antibody we have developed that cross‐reacts with Leu 7). None of the patients had leukemic blasts that reacted with Leu 11b. However, leukemic blasts from four T‐ALL patients were 1G2 + and/or Leu 7 + . Blasts from two of these had spontaneous lytic activity against standard NK target cell line K562; blasts from one killed K562 only when incubated with interferon; blasts from the other had no lytic activity against K562 but did manifest antibody‐dependent cell‐mediated cytotoxicity against antibody‐coated cells from NK‐resistant cell line SB. Blasts from all four Leu 7 + patients had L2 morphology. In one, the leukemic blasts had azurophilic cytoplasmic granules similar to those found in NK‐enriched normal populations of large granular lymphocytes. These findings suggest that a significant proportion of T‐cell acute lymphoblastic leukemias may be malignancies of NK cell origin.
A scientist's fiancée wants to tidy his desk in 1861
Authors: Jeremy Hugh Baron
Journal: BMJ (2005)

resources given to patients' safety in general.Furthermore, to reduce the incidence of potassium related (and other medications) errors-many of which are preventable-effectively, hospitals must go beyond investigating individual incidents and focus more on identifying and implementing effective, systems based improvements that are grounded in evidence of reasonable quality. ConclusionsThis systematic review highlights the lack of strong evidence in support of specific best practice initiatives related to the safe handling of potassium containing products.The quality and quantity of evidence in support of best practices related to other patient safety issues is likely in a similar state.If the aim is to identify and implement the most effective medication safety practices, then systems oriented evaluation research accompanied by implementation of evidence based medication safety practices is essential.The need is especially urgent given our main finding that no valid studies evaluate the effectiveness of any of the practices currently recommended for the safe handling of products containing potassium.
Papillary Carcinoma Arising in Sublingual Ectopic Thyroid Concentrating Both Tc-99m Pertechnetate and I-131 Diagnosis by Fine Needle Aspiration Cytology
Authors: GITA JAYARAM, ARUN KAKAR, RAJEEV PRAKASH
Journal: Clinical Nuclear Medicine (1995)

A 16-year-old boy had a sublingual swelling of 3 months' duration and features of hypothyroidism. Tc-99m pertechnetate and I-131 images showed good uptake of administered radionuclide in the sublingual nodule. No thyroid tissue was present in the normal anatomical location in the neck, which was also confirmed by subsequent ultrasonography. Fine-needle aspiration from the ectopic thyroid yielded highly cellular material, the cytologic picture being suggestive of a papillary carcinoma. The mass was removed surgically and confirmed on pathology to be a papillary thyroid carcinoma. The rare possibility of a functioning ectopic thyroid being malignant should not be overlooked, with fine needle aspiration cytology being used to aid in diagnosis.
ANALYSIS OF CERTAIN FACTORS IN HISTORIES OF TWO HUNDRED SOLDIERS DISCHARGED FROM THE ARMY FOR NEUROPSYCHIATRIC DISABILITIES
Authors: SEYMOUR J. ROSENBERG, RICHARD H. LAMBERT
Journal: American Journal of Psychiatry (1942)

1. We have reviewed 200 consecutive case histories of soldiers discharged from the army at Camp Lee, Virginia, because of neuropsychiatric disabilities. 2. Of that group about one-half were psychoneurotic, a little less than a third psychotic, and about one-sixth epileptic. 3. Eighty-three per cent presented prominent symptoms for at least one year before induction; a little more than half for over 5 years. Of the 11 per cent in which the onset occurred after induction, all but one patient were psychotic. 4. Almost half became disabled within the first month of military service, 75 per cent within two months, and 97 per cent within 6 months after they began army duty. 5. Only 18.5 per cent had good work records. 6. Thirty-nine and five-tenths per cent had heavily loaded family histories. 7. Military service, in itself, could not be said to be the cause of the disabilities in the majority of our cases. 8. The majority of the psychiatric casualties we encountered could have been eliminated at the induction board if relatively simple social service data had been made available.
Best estimates of coronary risk of passive smoking are needed
Authors: Ruoling Chen, Hugh Tunstall-Pedoe, Roger Tavendale
Journal: BMJ (2004)

EDITOR—Whincup et al show passive inhalation of environmental tobacco smoke to be an unexpectedly strong risk factor for coronary heart disease, when assessed using serum cotinine concentrations, in contrast to Enstrom and Kabat, who did not.1 2 They emphasise the need for further prospective studies using biomarkers.

We measured serum cotinine concentration and other biomarkers of smoking at …
Sensitization to Aspergillus fumigatus and lung function in children with cystic fibrosis.
Authors: C Wojnarowski, I Eichler, C Gartner, M Götz, S Renner, D Y Koller, T Frischer
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Colonization with Aspergillus fumigatus (Af) constitutes a common finding in children with cystic fibrosis (CF). The relationship between sensitization to Af and lung functon (LF) was studied in 118 patients with CF (61 girls and 57 boys; mean age: 14.3 yr; SD: 7 yr). Mean follow up was 2.2 yr. On average, 8.1 (SD: 4.8) LF tests were performed per patient. Measurement of total IgE and specific IgE antibodies to Af, and a skin prick test (SPT) for Af, were done once a year. Thirty-one children (26%) were sensitized to Af. On average, LF parameters were not significantly different in Af-sensitized children than in nonsensitized children. Linear regression analyses were performed, using the repeated measures design. With adjustment for gender, age, height, and weight, sensitization to Af was associated with lower values of FEV1 (beta = -0.209; p < 0.05) and FEF(25-75) (beta = -0.356; p < 0.01). Analysis of different subgroups of sensitization demonstrated the effect on LF only in Af-sensitized patients with elevated total IgE levels, and not in Af-sensitized patients with normal IgE levels. Furthermore, there was evidence for a more rapid decline in LF for Af-sensitized patients with elevated total IgE levels than in those with normal IgE levels. We conclude that sensitization to Af in the presence of increased IgE values is associated with lower LF values in children with CF.
Serum Selenium Concentrations and Diabetes in U.S. Adults: National Health and Nutrition Examination Survey (NHANES) 2003–2004
Authors: Martin Laclaustra, Ana Navas-Acien, Saverio Stranges, Jose M. Ordovas, Eliseo Guallar
Journal: Environmental Health Perspectives (2009)

Increasing evidence suggests that high selenium levels are associated with diabetes and other cardiometabolic risk factors.We evaluated the association of serum selenium concentrations with fasting plasma glucose, glycosylated hemoglobin levels, and diabetes in the most recently available representative sample of the U.S. population.We used a cross-sectional analysis of 917 adults > or = 40 years of age who had a fasting morning blood sample in the National Health and Nutrition Examination Survey 2003-2004. We evaluated the association of serum selenium, measured by inductively coupled plasma-dynamic reaction cell-mass spectrometry, and diabetes, defined as a self-report of current use of hypoglycemic agents or insulin or as fasting plasma glucose > or = 126 mg/dL.Mean serum selenium was 137.1 microg/L. The multivariable adjusted odds ratio [95% confidence interval (CI)] for diabetes comparing the highest quartile of serum selenium (> or = 147 microg/L) with the lowest (< 124 microg/L) was 7.64 (3.34-17.46). The corresponding average differences (95% CI) in fasting plasma glucose and glycosylated hemoglobin were 9.5 mg/dL (3.4-15.6 mg/dL) and 0.30% (0.14-0.46%), respectively. In spline regression models, the prevalence of diabetes as well as glucose and glycosylated hemoglobin levels increased with increasing selenium concentrations up to 160 microg/L.In U.S. adults, high serum selenium concentrations were associated with higher prevalence of diabetes and higher fasting plasma glucose and glycosylated hemoglobin levels. Given high selenium intake in the U.S. population, further research is needed to determine the role of excess selenium levels in the development or the progression of diabetes.
Possible Infection of Man by Indirect Transmission of Trichophyton Discoides
Authors: J. Walker
Journal: BMJ (1955)

A notable increase in the number of cases of infection in man by Trichophyton discoides, the principal cause of cattle ringworm, diagnosed in various parts of Great Britain and Northern Ireland has been evident in recent years.This may be attributable in part to a higher proportion of the infected persons seeking medical assis- tance, but in greater measure to an actual increase in the incidence of the disease.In many instances the infection in man can be traced to contact with an animal, usually a calf, suffering from ringworm, occasionally to contact with another human being; but in a significantly large number of cases there is no history of any direct contact with the disease.In such cases it has been assumed that the infection was transmitted in an indirect way by contact with infective hairs, scales, or crusts deposited, from animals, on the ground, on the woodwork of cattle stalls, on scratching- posts, and elsewhere.However, in support of this
Results of Double-blind, Multicentre Study with Ritodrine in Premature Labour
Authors: A. W.-D. Casparis, M. Thiery, A. Y. Le Sian, K. Baumgarten, I. Brosens, O. Gamisans, J. G. Stolk, W. Vivier
Journal: BMJ (1971)

A double-blind placebo-controlled multicentre study with ritodrine, a β-mimetic uterine relaxant, has been performed in 91 patients in premature labour. All patients were treated according to a fixed dosage scheme consisting of an intravenous infusion followed by oral tablets for a total of seven days. Ritodrine arrested premature labour in 80%, the placebo in 48% of the patients (P=0·02). This short treatment, however, was usually not sufficient to prolong gestation till term. Apart from a slight to moderate rise in maternal heart rate and a slight rise in systolic blood pressure, ritodrine did not give rise to any maternal or fetal side effects. The problems of patient selection and of evaluation of the results are discussed.
Access to Care as a Component of Health System Reform
Authors: Phil B. Fontanarosa, Drummond Rennie, Catherine D. DeAngelis
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COST BENEFIT ANALYSIS OF TRANSCATHETER AORTIC VALVE IMPLANTATION COMPARED TO CONVENTIONAL MEDICAL TREATMENT INCLUDING VALVULOPLASTIES IN PATIENTS WITH SEVERE AORTIC STENOSIS
Authors: Soon Wei Neoh, Brid Galvin, Ciara Mahon, Ciaran O’ Neill, Sinead Teehan, James Crowley, Peter Crean, Faisal Sharif
Journal: Journal of the American College of Cardiology (2013)