tbuckley/cabot-search huggingface dataset:
Initiation of Insulin in Patients With Type 2 Diabetes Failing Oral Therapy
Authors: Nasser E. Mikhail, Dennis Cope
Journal: Diabetes Care (2005)

We read with interest the two studies conducted by Janka et al. (1) and Raskin et al. (2) and the accompanying editorial (3) regarding the initiation of insulin in patients with type 2 diabetes failing oral agents and noted the apparent discrepancy between the study results. We believe that the data of the two previous trials (1,2) may not be necessarily conflicting. One important factor that contributed to the more favorable HbA1c levels with insulin aspart 70/30 compared with insulin glargine in the study of Raskin …
Review: Primary care–based general health checks improve surrogate but not clinical outcomes
Authors: Chris Del Mar
Journal: Annals of Internal Medicine (2014)

ACP Journal Club17 June 2014Review: Primary care–based general health checks improve surrogate but not clinical outcomesChris Del Mar, MDChris Del Mar, MDBond University, Gold Coast, Queensland, Australia (C.D.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-160-12-201406170-02005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationSi S, Moss JR, Sullivan TR, Newton SS, Stocks NP. Effectiveness of general practice–based health checks: a systematic review and meta-analysis. Br J Gen Pract. 2014;64:e47-53. https://pubmed.ncbi.nlm.nih.gov/24567582Clinical Impact RatingsGIM/FP/GP: References1 Krogsbøll LT, Jørgensen KJ, Grønhøj Larsen C, Gøtzsche PC. General health checks in adults for reducing morbidity and mortality from disease. Cochrane Database Syst Rev. 2012;10:CD009009. [PMID: 23076952] Google Scholar2 US Preventive Services Task Force. Recommendations. www.uspreventiveservicestaskforce.org/recommendations.htm (accessed 9 Apr 2014). Google Scholar3 Canadian Task Force on Preventive Health Care. Guidelines. www.canadiantaskforce.ca/guidelines/ (accessed 9 Apr 2014). Google Scholar Author, Article, and Disclosure InformationAuthors: Chris Del Mar, MDAffiliations: Bond University, Gold Coast, Queensland, Australia (C.D.M.)This article was published at Annals.org on 3 June 2014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 17 June 2014Volume 160, Issue 12Page: JC5KeywordsBlood pressureBody mass indexMedical risk factorsMortalityOdds ratioPopulation statisticsPrimary careSmoking cessationSystematic reviewsSystolic pressure ePublished: 17 June 2014 Issue Published: 17 June 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Age at Diagnosis and Outcome for Women With Ductal Carcinoma-In-Situ of the Breast: A Critical Review of the Literature
Authors: Frank A. Vicini, Abram Recht
Journal: Journal of Clinical Oncology (2002)

PURPOSE: Patients younger than 35 to 45 years old at the time of diagnosis of invasive breast cancer have been found to have a worse prognosis than older patients in many studies. However, the impact of patient age at diagnosis on the outcome of treatment with either lumpectomy and radiation therapy (RT) or mastectomy for patients with ductal carcinoma-in-situ (DCIS) of the breast has not been extensively analyzed. MATERIALS AND METHODS: Articles addressing the effect of patient age at diagnosis on the outcome of treatment of DCIS with lumpectomy and RT or mastectomy were identified through the MEDLINE and CancerLit databases and reference lists of relevant articles. Studies were reviewed to determine the impact of patient age at diagnosis on clinical and pathologic features of DCIS, the influence of age on outcome after lumpectomy and RT, and the impact of age on outcome after mastectomy. RESULTS: DCIS in younger patients more frequently contains adverse prognostic pathologic factors and extends over a greater distance in the breast than in older patients. In series with adequate follow-up, younger patients treated with lumpectomy and RT had a significantly higher rate of local recurrence than older patients, especially for invasive local recurrences. Some studies have suggested that careful attention to margin status and excising larger volumes of tissue can reduce this difference substantially. No available data show that younger patients have better long-term cancer-free survival rates if treated by mastectomy rather than lumpectomy and RT. CONCLUSION: Successful treatment of younger patients with DCIS with lumpectomy and RT requires careful attention to patient evaluation, selection, and surgical technique. When this is done, age at diagnosis should not be a contraindication to breast-conserving therapy.
IMPACT OF SOCIETY OF CHEST PAIN CENTERS ACCREDITATION ON QUALITY: AN ACTION REGISTRY GET WITH THE GUIDELINES (ARG) ANALYSIS
Authors: W. Frank Peacock, Ezra Amsterdam, Christopher Cannon, Deborah Diercks, Lee Garvey, Louis Graff, DaJuanicia Holmes, Kay Holmes, James McCord, Kristin Newby, Matthew Roe, Michael Ross
Journal: Journal of the American College of Cardiology (2011)
THE INFLUENCE OF HEAT ON DIFFERENT SERA AS CULTURE MEDIA FOR GROWING TISSUES
Authors: Ragnvald Ingebrigtsen
Journal: The Journal of Experimental Medicine (1912)

1. Bone marrow of guinea pigs grows better in autogenic than in homogenic serum. 2. Bone marrow of guinea pigs grows more extensively and rapidly in unheated than in heated autogenic and homogenic serum (56 degrees C. for half an hour). 3. In different heterogenic sera, there are differences in the growth of the tissue. In none of the sera examined, was the growth so extensive as in homogenic and autogenic serum. 4. Heated heterogenic serum is a better culture medium and shows more extensive tissue growth than normal unheated heterogenic serum.
Diving, Patent Foramen Ovale, and Brain Lesions
Authors: Anne-Marie Bollen
Journal: Annals of Internal Medicine (2001)

Letters20 November 2001Diving, Patent Foramen Ovale, and Brain LesionsAnne-Marie Bollen, PhDAnne-Marie Bollen, PhDUniversity of Washington; Seattle, WA 98195 (Bollen)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-10-200111200-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The following three points in the report by Schwerzmann and associates (1) on diving risks and ischemic brain lesions need clarification. First, if 19 of 52 divers and 6 of 52 nondivers had ischemic brain lesions, the reported odds ratio of 5.8 appears incorrect. The reported frequencies suggest an odds ratio of 4.41 (95% CI, 1.59 to 12.25).Second, the significant P values for comparisons between divers and nondivers appear to be inconsistent with the data. The report suggests that P values were calculated by using nonparametric statistics with a Bonferroni correction. With four compared groups, the ...Reference1. Schwerzmann M, Seller C, Lipp E, Guzman R, Lövbald KO, Kraus M, et al . Relation between directly detected patent foramen ovale and ischemic brain lesions in sport divers. Ann Intern Med. 2001;134:21-4. [PMID: 11187416] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Anne-Marie Bollen, PhDAffiliations: University of Washington; Seattle, WA 98195 (Bollen) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRelation between Directly Detected Patent Foramen Ovale and Ischemic Brain Lesions in Sport Divers Markus Schwerzmann , Christian Seiler , Ernst Lipp , Raphael Guzman , Karl O. Lövblad , Martin Kraus , and Nils Kucher Diving, Patent Foramen Ovale, and Brain Lesions Markus Schwerzmann and Christian Seiler Diving, Patent Foramen Ovale, and Brain Lesions Lawrence Martin Metrics 20 November 2001Volume 135, Issue 10Page: 928-929KeywordsBrainHypertensionLesionsOdds ratioResearch designRisk management ePublished: 20 November 2001 Issue Published: 20 November 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Vascular Endothelial-Specific Dimethylarginine Dimethylaminohydrolase-1–Deficient Mice Reveal That Vascular Endothelium Plays an Important Role in Removing Asymmetric Dimethylarginine
Authors: Xinli Hu, Xin Xu, Guangshuo Zhu, Dorothee Atzler, Masumi Kimoto, Ju Chen, Edzard Schwedhelm, Nicole Lüneburg, Rainer H. Böger, Ping Zhang, Yingjie Chen
Journal: Circulation (2009)

Background— Asymmetrical methylarginines inhibit NO synthase activity and thereby decrease NO production. Dimethylarginine dimethylaminohydrolase 1 (DDAH1) degrades asymmetrical methylarginines. We previously demonstrated that in the heart DDAH1 is predominantly expressed in vascular endothelial cells. Because an earlier study showed that mice with global DDAH1 deficiency experienced embryonic lethality, we speculated that a mouse strain with selective vascular endothelial DDAH1 deficiency (endo-DDAH1 −/− ) would largely abolish tissue DDAH1 expression in many tissues but possibly avoid embryonic lethality. Methods and Results— By using the LoxP/Cre approach, we generated the endo-DDAH1 −/− mice. The endo-DDAH1 −/− mice had no apparent defect in growth or development compared with wild-type littermates. DDAH1 expression was greatly reduced in kidney, lung, brain, and liver, indicating that in these organs DDAH1 is distributed mainly in vascular endothelial cells. The endo-DDAH1 −/− mice showed a significant increase of asymmetric dimethylarginine concentration in plasma (1.41 μmol/L in the endo-DDAH1 −/− versus 0.69 μmol/L in the control mice), kidney, lung, and liver, which was associated with significantly increased systolic blood pressure (132 mm Hg versus 113 mm Hg in wild-type). The endo-DDAH1 −/− mice also exhibited significantly attenuated acetylcholine-induced NO production and vessel relaxation in isolated aortic rings. Conclusions— Our study demonstrates that DDAH1 is highly expressed in vascular endothelium and that endothelial DDAH1 plays an important role in regulating blood pressure. In the context that asymmetric methylarginines are broadly produced by many type of cells, the strong DDAH1 expression in vascular endothelium demonstrates for the first time that vascular endothelium can be an important site to actively dispose of toxic biochemical molecules produced by other types of cells.
The superiority of maximum fiber elastance over maximum stress-volume ratio as an index of contractile state.
Authors: T Wisenbaugh, G Yu, J Evans
Journal: Circulation (1985)

The end-systolic pressure-volume relationship has been used as a load-independent measure of ventricular pump performance. Since comparisons of load between ventricles of different size and thickness may be more accurately made with measurements of wall stress than with those of pressure, the end-systolic stress-volume relationship at one or more levels of end-systolic stress has been used to estimate contractile function in hypertrophied ventricles. Linear regression of end-systolic stress against end-systolic volume for differently loaded beats has a slope termed maximum fiber elastance (fiber Emax) and a volume intercept termed Vo; the maximum stress-volume ratio (MSVR) for a single beat is an approximation of fiber Emax but assumes Vo = 0. However, the influence of preload, afterload, and inotropic state on these indexes has not been examined. We therefore studied the stress-volume relationship in seven open-chest dogs instrumented with ultrasonic crystals and micromanometers. Postextrasystolic potentiation (PESP) increased both the MSVR (5.7 +/- 1.83 vs 4.85 +/- 1.43 at control, p less than .05) and fiber Emax (13.93 +/- 3.24 vs 9.24 +/- 2.15 at control; p less than .05). Augmentation of preload by infusion of dextran, with the use of nitroprusside to maintain afterload relatively constant, did not significantly influence either the MSVR or fiber Emax. Vo was not significantly influenced by PESP, but was shifted to higher values by augmentation of preload (17.5 +/- 14.8 vs 13.9 +/- 11.1 ml at control; p less than .05).(ABSTRACT TRUNCATED AT 250 WORDS)
Sleep apnoea and systemic hypertension.
Authors: J R Stradling
Journal: Thorax (1989)

Sleep apnoea and systemic hypertensionGross obstructive sleep apnoea has two clear consequences, recurrent sleep disruption (with daytime sleepiness) and repeated noctural hypox- aemia.The importance of the hypoxaemia is debated but when it is severe, or perhaps in the presence of ischaemic heart disease, it may trigger off serious on July 13, 2023 by guest.
“Bovine ketosis” in a nondiabetic postpartum woman
Authors: Bart Chernow, Chris Finton, Thomas G Rainey, John T O'Brian
Journal: Diabetes Care (1982)

A 19-yr-old woman developed ketoacidosis 7 wk after the delivery of her first child. Despite breast feeding, she had been on a weight reduction diet resulting in a loss of 12 kg/body wt. With the development of a urinary tract infection, the patient became dehydrated and was found to be in ketoacidosis (arterial pH was 7.25 and PaCO2 was 17 mm Hg). The patient did not use alcohol and was nondiabetic. Therapy with adequate calories, intravenous fluids, and an appropriate antimicrobial agent resulted in prompt normalization of the laboratory abnormalities and resolution of the patient's symptoms. The hypothesis is advanced that the postpartum status of the patient put her at particular risk for development of ketoacidosis and that this may represent the first reported episode of “bovine ketosis” in a human.
Gut/brain axis and the microbiota
Authors: Emeran A. Mayer, Kirsten Tillisch, Arpana Gupta
Journal: Journal of Clinical Investigation (2015)

Tremendous progress has been made in characterizing the bidirectional interactions between the central nervous system, the enteric nervous system, and the gastrointestinal tract. A series of provocative preclinical studies have suggested a prominent role for the gut microbiota in these gut-brain interactions. Based on studies using rodents raised in a germ-free environment, the gut microbiota appears to influence the development of emotional behavior, stress- and pain-modulation systems, and brain neurotransmitter systems. Additionally, microbiota perturbations by probiotics and antibiotics exert modulatory effects on some of these measures in adult animals. Current evidence suggests that multiple mechanisms, including endocrine and neurocrine pathways, may be involved in gut microbiota-to-brain signaling and that the brain can in turn alter microbial composition and behavior via the autonomic nervous system. Limited information is available on how these findings may translate to healthy humans or to disease states involving the brain or the gut/brain axis. Future research needs to focus on confirming that the rodent findings are translatable to human physiology and to diseases such as irritable bowel syndrome, autism, anxiety, depression, and Parkinson's disease.
BLOOD PRESSURE AND ATRIAL FIBRILLATION: A COMBINED ATRIAL FIBRILLATION-CONGESTIVE HEART FAILURE AND ATRIAL FIBRILLATION FOLLOW-UP INVESTIGATION OF RHYTHM MANAGEMENT ANALYSIS
Authors: Michel White, Maxime Tremblay-Gravel, Denis Roy, Hugues Leduc, D. George Wyse, Julia Cadrin-Tourigny, Laurent Macle, Marc Dubuc, Jason Andrade, Lena Rivard, Peter G. Guerra, Bernard Thibault, Mario Talajic, Paul Khairy
Journal: Journal of the American College of Cardiology (2013)
Role of cellular proteinases in acute myocardial infarction II. influence of in vivo suppression of myocardial proteolysis by antipain, leupeptin and pepstatin on myocardial infarct size in the rat
Authors: Roberto Bolli, Richard O. Cannon, Edith Speir, Robert E. Goldstein, Stephen E. Epstein
Journal: Journal of the American College of Cardiology (1983)
Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia
Authors: Rafael H. Jácomo, Barbara A. Santana-Lemos, Ana Silvia G. Lima, Patricia A. Assis, Ana Paula A. Lange, Lorena L. Figueiredo-Pontes, Luciana O. Oliveira, Sarah C. Bassi, Mariana T. L. Benício, Márcia S. Baggio, Aglair B. Garcia, Roberto P. Falcão, Eduardo M. Rego
Journal: Blood (2012)
Occurrence of thrombotic events in acute promyelocytic leukemia correlates with consistent immunophenotypic and molecular features
Authors: M Breccia, G Avvisati, R Latagliata, I Carmosino, A Guarini, M S De Propris, F Gentilini, M C Petti, G Cimino, F Mandelli, F Lo-Coco
Journal: Leukemia (2006)
Da Costa's Syndrome: Aetiology. Lecture III
Authors: P. Wood
Journal: BMJ (1941)

Practical points in the ordering, regulation, and measure- ment of feeds for bottle-fed babies are discussed, and methods of minimizing the risk of quantitative errors are indicated.The employment of feeds providing 20 calories per fluid ounce for all infants, unless there is some special contraindication, is strongly urged on the ground that thereby (a) there is a much-reduced -risk of quantitative mistakes for the infant, (b) feeding is greatly simplified for doctors and nurses, and (c) labour is lessened in children's wards or day nurseries.Tables are given for the instruction of nurses in infant feeding.These can be adapted and shortened by the doctor in accordance with the type of feeding he habitually uses.It is hoped that feeding standardized to the extent here sug- gested may be widely adopted at the present time, for it offers a way of coping with the difficulty of ordering feeds for large numbers of babies brought into reception areas on feeds of every description.
Dermatology in Britain in the late nineteenth century
Authors: ARTHUR ROOK
Journal: British Journal of Dermatology (1979)

Journal Article Dermatology in Britain in the late nineteenth century Get access ARTHUR ROOK ARTHUR ROOK Addenbrooke's Hospital, Hills Road, Cambridge Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 100, Issue 1, 1 January 1979, Pages 3–12, https://doi.org/10.1111/j.1365-2133.1979.tb03564.x Published: 01 January 1979
Late‐onset neutropenia following RCHOP chemotherapy in diffuse large B‐cell lymphoma
Authors: Gillianne Geet Yi Lai, Soon‐Thye Lim, Miriam Tao, Alexandre Chan, Huihua Li, Richard Quek
Journal: American Journal of Hematology (2009)

Abstract Rituximab has been associated with the development of late‐onset neutropenia (LON). As only heterogeneous studies have been conducted, its incidence and clinical course remain unclear. We aim to: (1) study the incidence and clinical relevance of WHO grade 3/4 LON in a uniform group of patients with diffuse large B‐cell lymphoma (DLBCL) in complete remission following curative rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (RCHOP) chemotherapy; (2) ascertain predictive factors for LON. The 121 eligible patients identified from our prospectively maintained database were followed up for occurrence of WHO grade 3/4 LON. The clinical course of LON was documented, and its relationship with patient‐ and tumor‐related factors was analyzed. With a median follow‐up of 883 days (range, 265–1762), 13.2% had developed LON of grade 3/4. The median time to neutrophil nadir was 129 days (range, 39–277). The median time to recovery was 69 days (range, 3–349) and occurred in all except two patients. Only one episode of nonlife threatening bacterial culture‐positive urinary tract infection and pulmonary tuberculosis, both occurring in the same patient was documented. Results of Fischer's exact test revealed that age, stage, LDH level, ECOG, marrow involvement, and hematologic parameters did not predict for LON development. WHO grade 3/4 LON is not infrequent in patients with DLBCL receiving RCHOP. Even so, it is reassuring that LON is self‐limiting and unassociated with life‐threatening infection. A watchful waiting approach is appropriate in majority of patients who develop LON following RCHOP. Am. J. Hematol., 2009. © 2009 Wiley‐Liss, Inc.
Association Between Increased Platelet P-Selectin Expression and Obesity in Patients With Type 2 Diabetes
Authors: David J. Schneider, Regina M. Hardison, Neuza Lopes, Burton E. Sobel, Maria Mori Brooks
Journal: Diabetes Care (2009)

OBJECTIVE To determine whether obesity increases platelet reactivity and thrombin activity in patients with type 2 diabetes plus stable coronary artery disease. RESEARCH DESIGN AND METHODS We assessed platelet reactivity and markers of thrombin generation and activity in 193 patients from nine clinical sites of the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D). Blood taken at the time of enrollment was used for assay of the concentration of prothrombin fragment 1.2 (PT1.2, released when prothrombin is activated) and fibrinopeptide A (FPA, released when fibrinogen is cleaved). Platelet activation was identified with the use of flow cytometry in response to 0, 0.2, and 1 μmol/l adenosine diphosphate (ADP). RESULTS Concentrations of FPA, PT1.2, and platelet activation in the absence of agonist were low. Greater BMI was associated with higher platelet reactivity in response to 1 μm ADP as assessed by surface expression of P-selectin (r = 0.29, P &amp;lt; 0.0001) but not reflected by the binding of fibrinogen to activated glycoprotein IIb-IIIa. BMI was not associated with concentrations of FPA or PT1.2. Platelet reactivity correlated negatively with A1C (P &amp;lt; 0.04), was not related to the concentration of triglycerides in blood, and did not correlate with the concentration of C-reactive peptide. CONCLUSIONS Among patients enrolled in this substudy of BARI 2D, a greater BMI was associated with higher platelet reactivity at the time of enrollment. Our results suggest that obesity and insulin resistance that accompanies obesity may influence platelet reactivity in patients with type 2 diabetes.
REMOVAL OF SKIN SUTURES
Authors: Conrad A. Etzel
Journal: JAMA (1953)

To the Editor:—  After reading the article Easy Removal of Skin Sutures, by Drs. Weinstein and Roberts (J. A. M. A.[July 25] 1953) we agree with the authors that their suture lift is a valuable method for removing skin sutures. We have found, however, that it is easier to use the eye end of the needle in inserting the lift. This blunt end slips under the stitch easily without piercing the skin. We also tie the loose end of the first knot to the loose end of the last knot so that the suture lift can be easily identified. With these two additions to the technique, we have found the time necessary for insertion of the lift markedly reduced.