tbuckley/cabot-search huggingface dataset:
Values and Limitations of Exercise Electrocardiography
Authors: ROBERT A. BRUCE
Journal: Circulation (1974)

Values and Limitations of Exercise ElectrocardiographyELECTROCARDIOGRAPHY enhances the safety as well as the diagnostic and prognostic values of exercise testing of ambulatory, middle-aged persons.It is essential for the occasional detection of clinically unsuspected acute myocardial infarction in individuals at rest who should not be exercised.It reveals hazardous exertional arrhythmias which in- dicate exercise testing should be interrupted.For ex- ample, three or more consecutive ventricular premature beats may be the prelude to ventricular tachycardia or fibrillation with exertional cardiac arrest.It also reveals postexertional ST segment depression in excess of defined tolerance limits suggestive of myocardial ischemia.Quantitatively, these tolerance limits vary with the ECG lead(s) used, performance characteristics (calibration, frequency responses, damping) of the electrocardiograph, the type, relative stress and time-course of exercise and recovery as well as sex and age of individuals tested.When segmental ST depression (not merely junctional) exceeds such limits, various causes of in- sufficient coronary supply of oxygenated blood and ex- cessive myocardial demands for aerobic metabolism need to be differentiated.In other words ST depression is merely a functional sign, not morphologic evidence, of an abnormal metabolic demand-supply relationship at the myocardial cell membrane.Besides coronary artery disease, which is common in economically developed populations, other causes in- clude anemia; hypoxemia from altitude or
AN IMMUNOLOGIC BASIS FOR ACQUIRED RESISTANCE TO ORAL ADMINISTRATION OF HOG INTRINSIC FACTOR AND VITAMIN B12 IN PERNICIOUS ANEMIA*
Authors: Louis Lowenstein, Bernard A. Cooper, Lauder Brunton, Susan Gartha
Journal: Journal of Clinical Investigation (1961)

In pernicious anemia, vitamin B12 deficiency develops owing to the failure of gastric intrinsic- factor secretion.Patients with this disease absorb vitamin B12 from the gastrointestinal tract when it is fed together with an extract of hog pyloric mucosa.Some patients have relapsed during the course of oral therapy with this mixture (1-3).These subjects absorb vitamin B1.2 administered with normal human gastric juice but do not absorb it when it is administered with hog preparations possessing intrinsic-factor activity (3).These patients have become refractory to the hog preparations.It has been reported that sera obtained from most of these refractory pa- tients (4), and from a minority of nonrefractory patients and normal subjects (5, 6), possess in- trinsic factor-neutralizing properties.Such observations have directed attention to a possible immunologic mechanism for the refrac- tory state.This study was undertaken to deter- mine whether the refractory state might be due to antibodies against the hog intrinsic-factor prepara- tion, which could be detected in vitro. METHODS AND MATERIALSThe standard hog pyloric mucosal extract1 (hog IF) was active in the Schilling test at a dosage of 100 mg.Normal human gastric juice was obtained from at least 4 donors after histamine stimulation.After filtration
Epinephrine Levels in the Peripheral Blood During Irreversible Hemorrhagic Shock in Dogs
Authors: CARL J. GREEVER, DANIEL T. WATTS
Journal: Circulation Research (1959)

Dogs were bled to a mean arterial pressure of 40 mm. Hg until 10 per cent of the shed blood had automatically reinfused from an elevated reservoir. The remaining blood was then rapidly infused intravenously. The procedure was fatal to all 13 dogs. Arterial blood epinephrine levels were followed during the time of hemorrhage and the post-hemorrhagic survival period in 9 of these animals. Arterial blood epinephrine levels in the 9 dogs increased from control values of less than one µg./L. to a maximum of 29 µg./L. during early hemorrhage, and then decreased during the period of spontaneous reinfusion to 7.5 µg./L. After complete reinfusion the blood pressure returned to normal, and epinephrine disappeared from the circulation. The blood pressure then gradually failed under normovolemic conditions, and the animals died in shock after an average of 220 minutes. Blood samples obtained immediately before death when the mean arterial pressure was 45 mm. Hg contained only 3.5 µg./L. epinephrine.
Hemodynamic Abnormalities of the Postinfarction Left Ventricle.
Authors: William A. Baxley
Journal: Annals of Internal Medicine (1968)

s1 May 1968Hemodynamic Abnormalities of the Postinfarction Left Ventricle.William A. Baxley, M.D., Harold T. Dodge, M.D., F.A.C.P.William A. Baxley, M.D.Search for more papers by this author, Harold T. Dodge, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1151_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwenty patients with chronic postinfarction angina or left ventricular failure were studied with cardiac catheterization and either quantitative biplane or cineangiocardiography or both. Ten patients had localized ventricular contraction abnormalities as follows: one had a ventricular aneurysm of 231 ml volume with paradoxical expansion of 34 ml per stroke resulting in a 53 gram-meters per stroke work overload of the remaining ventricular myocardium; one had an aneursym of 24 ml with only 6 ml of paradoxical expansion; one had an aneurysm of 214 ml contracting to 173 ml during systole indicating functioning contractile elements in its wall; five had aneurysms... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Birmingham, Alabama PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1151-1152KeywordsAneurysmsAnginaCatheterizationHemodynamicsLeft ventricleMyocardiumStrokeSystole Issue Published: 1 May 1968 PDF DownloadLoading ...
Effect of nickel sulfate on testicular steroidogenesis in rats during protein restriction.
Authors: Kusal K Das, Shakuntala Dasgupta
Journal: Environmental Health Perspectives (2002)

Nickel, a widely used heavy metal, exerts potent toxic effects on peripheral tissues as well as on the reproductive system. Low dietary protein coupled with exposure to this metal induces more severe changes, including biochemical defects, structural disorders, and altered physiologic functions. This study was designed to assess the effects of nickel sulfate on testicular steroidogenesis and to ascertain whether such alterations are reversible with normal protein and protein-restricted dietary regime. Nickel sulfate [2 mg/100 g body weight (bw)] dissolved in double-distilled water was administered on alternate days for 10 doses in a normal protein diet (18% casein) and a protein-restricted diet (5% casein) to Wistar male albino rats (bw 160 +/- 5 g). Two groups, one with a normal protein diet and the other with a protein-restricted diet, served as controls. Twenty-four hours after the last treatment, all the animals except those in withdrawal groups were sacrificed by decapitation. We observed a significant reduction in the activities of the testicular steroidogenic enzymes and plasma testosterone concentration accompanied by a significant elevation in cholesterol and ascorbic acid level in both dietary groups. After 15 days of withdrawal from the nickel sulfate treatment, the testicular steroidogenic enzymes, along with plasma testosterone level, improved significantly in both normal protein-fed and protein-restricted dietary groups. The effects of nickel on testicular cholesterol and ascorbic acid concentration were also reduced after withdrawal. Our results indicate that nickel sulfate affects the steroidogenic enzymes, causing alteration in the formation of testosterone in both dietary groups, which was manifested in the elevated cholesterol and ascorbic acid level with decreased activities of steroidogenic enzymes in adult rats testes. However, these alterations were reversible in both groups of animals fed normal protein diets and protein-restricted diets.
Cat Ownership and Fel d 1 in Bed Dust were Associated with Increased Sensitization to Cat, but Not Asthma Symptoms Among Middle-income Children in New York City
Authors: O.E. Olmedo, I.F. Goldstein, L. Acosta, A. Divjan, A.G. Rundle, G.L. Chew, R.B. Mellins, L. Hoepner, H. Andrews, S. Lopez-Pintado, J.W. Quinn, F.P. Perera, R.L. Miller, J.S. Jacobson, M.S. Perzanowski
Journal: Journal of Allergy and Clinical Immunology (2011)
Action against contraceptive implant threatened
Authors: C. Dyer
Journal: BMJ (1995)

Norplant provides contraception over a five-year period through the gradual subcutaneous release of the progestogen levonorgestrel. It has been on the US market since 1991 and available in Great Britain since 1993. Already the subject of group legal actions in several US states, Norplant may soon be the target of lawyers in Britain for litigation. The lawyers allege that insertion of the implant under the skin of the upper arm by untrained doctors has led to painful and difficult removals and left women with scarred arms. Moreover, insufficient warning has been given about possible side effects such as mood swings and continuous vaginal bleeding. Hoechst Roussel, marketer of the implant in Britain, however, argues that only doctors trained in Norplant insertion and removal should attempt either procedure. Removal will be problematic only if preceded by a problem insertion. Hoechst Roussel recently advised gynecologists, in writing, not to attempt to extract the implant unless they are trained in the removal technique. By British law, the application of a drug product once approved for general release to general practitioners and family planning doctors cannot be restricted by a pharmaceutical company.
Patient work of breathing during pressure support and volume-cycled mechanical ventilation.
Authors: J W Kreit, M W Capper, W L Eschenbacher
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

A computer-assisted technique based on the equation of motion of the respiratory system was used to measure inspiratory work of breathing in 11 patients during pressure support ventilation (PSV) and assisted, volume-cycled mechanical ventilation (AMV). During both modes of ventilation, patient work of breathing was calculated as the difference between the total work performed on the respiratory system (as predicted by the equation of motion) and the work performed by the ventilator. Patient work of breathing during AMV was also calculated as the difference between ventilator work measured during assisted and controlled mechanical breaths. By either method of work calculation, patient work of breathing during AMV was less than previously reported. In addition, when equal tidal volumes were delivered, there was no significant difference between the work performed by the patient during AMV and PSV. Patient work of breathing during PSV was found, however, to vary inversely with the level of pressure support. We conclude that: (1) patient work of breathing during AMV and PSV can be calculated using a computer-assisted technique based on the equation of motion of the respiratory system, and (2) depending on the amount of pressure support provided, patient work of breathing during PSV may be greater than, less than, or equal to the work performed during AMV.
The Color Cover Annual Report
Authors: George T. Wohl
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
(5) Incontinentia pigmenti. Bloch-Sulzberger syndrome
Authors: S.S. Bleehen, M.L. Wood
Journal: British Journal of Dermatology (1986)

Journal Article (5) Incontinentia pigmenti. Bloch‐Sulzberger syndrome Get access S.S. Bleehen, Drs, S.S. Bleehen, Drs Childrens Hospital, Sheffield Search for other works by this author on: Oxford Academic Google Scholar M.L. Wood M.L. Wood Childrens Hospital, Sheffield Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue s30, 1 July 1986, Page 47, https://doi.org/10.1111/j.1365-2133.1986.tb07700.x Published: 01 July 1986
Disinfection by Sulphur.
Authors: R. Harvey Reed
Journal: JAMA (1890)

<h3>To the Editor:</h3> —In yourJournalof February 8th I find an editorial on the " Correct Official Instructions as to Disinfection With Sulphur," in which article I find the following statement: " For a room 10 feet square use 3 pounds of sulphur, moistened with alcohol,<i>in an iron pan</i>placed in a tub containing a few inches of water, to avoid danger from fire." I desire to call attention to a great improvement on the old iron pan, which I have discarded long since as cumbersome, dangerous, unhandy and troublesome. In the place of this pan I have a light sheet-iron stove made, much after the style of a tinner's furnace, with a double bottom, the lower one of which is raised some three or four inches from the floor by suitable legs. On the one side of this little furnace, on a level with the upper bottom, is a
Association of HLA Class I Antigens with Diffuse Panbronchiolitis in Korean Patients
Authors: MYOUNG HEE PARK, YOUNG WHAN KIM, HO IL YOON, CHUL-GYU YOO, SUNG KOO HAN, YOUNG-SOO SHIM, WON DONG KIM
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Diffuse panbronchiolitis (DPB) is a chronic obstructive pulmonary disease of unknown etiology. Observations of significantly increased frequency of human leukocyte antigen (HLA)-B54 in Japanese patients and occurrence of familial cases suggest possible genetic predisposition to the disease susceptibility. To evaluate the possible association of HLA with the disease in Koreans, we have analyzed 30 patients for HLA class I (A, B, C) and class II (DR) antigens by the serologic and DNA typing methods, respectively. The most significant change in the patients compared to the control subjects was increased frequency of HLA-A11 (53.3% versus 17.5%, corrected p [pc] = 1.2 x 10(-)4, odds ratio [OR] = 5.4). In addition, B55 showed significant positive association (16.7% versus 3.5%, pc = 0.05, OR = 5.5), and B62 and Cw4 showed rather weak association with the disease. Certain A11-associated haplotypes showed much stronger positive association with the disease, compared to A11 antigen itself. Observations of a strong association of HLA-A11 in Koreans and B54 in Japanese with DPB suggest that the candidate gene(s) responsible for the disease susceptibility is located within the HLA class I region, most probably between HLA-A and HLA-B loci.
N,N'-Dibenzylethylenediamine Penicillin: A New Repository Form of Penicillin
Authors: A. P. Fletcher, C. R. Knappett
Journal: BMJ (1953)

ANURIA TREATED BY CORTISONE in the attack and before organic damage is done to the heart or kidneys.This view was expressed over two years ago by one of us (H.M.) as regards the heart when introducing Professor Philip S. Hench for the Honorary Degree conferred on him by the National University of Ireland.
Julian Thomas (“Tomi”) Spenser
Authors: Shmuel Reis, Eva Alkon-Katz, Jim Shalom, Jonathan Spenser
Journal: BMJ (2007)

Pioneered the first successful bone marrow transplants in children with primary immunodeficiency and became a fearless university administratorThe dreadful death of Roland Levinsky has shocked the world of paediatric oncology and genetics.He was an immunologist of international renown who performed the UK's first successful bone marrow transplant in children with primary immunodeficiency in 1979 at Great Ormond Street children's hospital.He went on to perform the UK's first successful attempts at gene therapy in children with fatal inherited diseases.He transformed the Institute of Child Health in London into a topclass research institution.Later, he did a similar makeover at Plymouth University, sending it soaring up the league tables.Levinsky was born in South Africa to a British-born mother and Polish/Lithuanian father.His father, died when Roland was 13.Two years later his mother returned to England with her three children.
Indian doctors debate incentives for organ donors
Authors: Ganapati Mudur
Journal: BMJ (2004)

New investigations in India of alleged trade in human kidneys have sparked a debate among doctors about whether the law on transplantation of organs should be changed to allow incentives to donors.

This month police in New Delhi probed the alleged role of public and private hospitals in the kidney trade. At the same time doctors warned that the number of renal transplants is dropping because hospitals are refusing cases involving donors unrelated to patients.

About 150 000 patients are diagnosed with end stage kidney disease in India each year. But the number …
Increased coronary perforation in the new device era. Incidence, classification, management, and outcome.
Authors: S G Ellis, S Ajluni, A Z Arnold, J J Popma, J A Bittl, N L Eigler, M J Cowley, R E Raymond, R D Safian, P L Whitlow
Journal: Circulation (1994)

The incidence of coronary perforation using new percutaneous revascularization techniques may be increased compared with PTCA. Still, perforation is uncommonly reported, and the optimal management and expected outcome remain unknown. The objectives of the study were to determine the incidence of coronary perforation using balloon angioplasty (percutaneous transluminal coronary angioplasty, PTCA) and new revascularization techniques and to develop optimal strategies for its management based on classification and outcome.Eleven sites with frequent use of new revascularization devices and prospective coding of consecutive procedures for coronary perforation during 1990 to 1991 contributed to a perforation registry. Patients with perforation were matched by device with an equal-sized cohort without perforation. Data were collected centrally, and all procedural cineangiograms were reviewed at a core angiographic laboratory. A classification scheme based on angiographic appearance of the perforation (I, extraluminal crater without extravasation; II, pericardial or myocardial blushing; III, perforation > or = 1-mm diameter with contrast streaming; and cavity spilling) was evaluated as a predictor of outcome and as a basis for management. Perforation was observed in 62 of 12,900 procedures reported (0.5%; 95% confidence interval, 0.4% to 0.6%), more commonly with devices intended to remove or ablate tissue (atherectomy, laser) than with PTCA (1.3%, 0.9% to 1.6% versus 0.1%, 0.1% to 0.1%; P < .001). The perforation population was notable for its advanced age (67 +/- 10 years) and high incidence of female sex (46%) (both P < .001 compared with patients without perforation). Perforation could be treated expectantly or with PTCA but without cardiac surgery in 85%, 90%, and 44% of class I, II, and III perforations, respectively. Class I perforations (n = 13, 21%) were associated with death in none, myocardial infarction in none, and tamponade in 8%. The incidences of these adverse events were 0%, 14%, and 13% in class II perforations (n = 31, 50%) and 19%, 50%, and 63% in non-cavity spilling class III perforations, respectively (n = 16, 26%). Two of the 15 instances of cardiac tamponade (13%) were delayed, occurring within 24 hours after dismissal from the catheterization laboratory.The incidence of perforation, while low, is increased with new devices. Women and the elderly are at highest risk. The clinical risk after perforation can be classified angiographically, but even low-risk perforations occasionally have poor clinical outcome. Patients should be observed for delayed cardiac tamponade for at least 24 hours.
Discrepancies in Thyroid Scans
Authors: Robert J. Wallner
Journal: JAMA (1979)

<h3>To the Editor.—</h3> This letter is in reference to the article, "Discrepancies Between Iodine and Technetium Thyroid Scintigraphy," by Barth et al (240:463, 1978). I have reviewed this article again following publication of the corrections inThe Journal(240:1340,1978). The illustrations are upside down. Figure 1 should be reversed with Fig 4, and Fig 2 should be reversed with Fig 3. However, the legends to the illustrations are correct after the figures have been repositioned. There are still several things that disturb me concerning the cases presented. In case 1, a barely minimal scanning dose of radionuclides was used. The 20-minute uptake of technetium in a normal thyroid gland is in the range of 4%,<sup>1</sup>which would make the scanning dose of technetium Tc 99m 20 μCi or less. If the scan using iodine 131 was performed at the 24- or 48-hour interval, the scanning dose was in the range
Inhibition of pathogenic SHIV replication in macaques treated with antisense DNA of interleukin-4
Authors: Navneet Kaur Dhillon, Yongjun Sui, Raghava Potula, Sukhbir Dhillon, Istvan Adany, Zhuang Li, Francois Villinger, David Pinson, Opendra Narayan, Shilpa Buch
Journal: Blood (2004)
Evaluation of Radiation-Induced Oral Mucositis by Optical Coherence Tomography
Authors: Thierry M. Muanza, Ana P. Cotrim, Mathew McAuliffe, Anastasia L. Sowers, Bruce J. Baum, John A. Cook, Felix Feldchtein, Paul Amazeen, C. Norman Coleman, James B. Mitchell
Journal: Clinical Cancer Research (2005)

Abstract Purpose: Optical coherence tomography (OCT) imaging was evaluated to determine if radiation-induced mucosal damage could be noninvasively monitored in real time and correlated with histopathologic findings. Experimental Design: Female C3H mice, ages 7 to 9 weeks, four per group, were immobilized in a custom-made Lucite jig and received 0, 15, 22.5, and 25 Gy in a single fraction to their oral cavity. OCT images were acquired of proximal, middle, and distal aspects of the dorsum of the tongue on days 0, 1, 3, 5, and 7 post-irradiation. Animals were sacrificed on day 7 and samples taken for histologic evaluation. OCT images were visually examined and also quantified by image analysis and compared with histologic findings. Results: Tongues removed 7 days post-irradiation showed no visible damage; however, upon staining with toluidine blue, ulcers at the base of the tongue became visible (100% for 25 Gy, 75% after 22.5 Gy, and 0% after 15 Gy). Visual inspection of OCT images qualitatively compared with histologic findings and quantitative image analysis of the OCT images (effective light penetration depth) revealed significant changes 7 days post-irradiation compared with unirradiated controls for the base of the tongue. Conclusions: OCT allows for direct noninvasive real-time acquisition of digitally archivable images of oral mucosa and can detect radiation-induced changes in the mucosa before visual manifestation. OCT may be a useful technique to quantify subclinical radiation-induced mucosal injury in experimental chemoradiation clinical trials.