The Vitamin D Endocrine System and the Hematolymphopoietic Tissue
Authors: STAVROS C. MANOLAGAS
Journal: Annals of Internal Medicine (1984)

Editorials1 January 1984The Vitamin D Endocrine System and the Hematolymphopoietic TissueSTAVROS C. MANOLAGAS, M.D., PH.D, LEONARD J. DEFTOS, M.D.STAVROS C. MANOLAGAS, M.D., PH.DSearch for more papers by this author, LEONARD J. DEFTOS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-1-144 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe importance of 1,25 dihydroxyvitamin D3(calcitriol), the hormone formed from two hydroxylations of the parent vitamin D, on mineral and skeletal metabolism is well established. The mineralotropic effects of calcitriol are produced in the classic target organs of vitamin D: intestine, bone, and kidney. However, the identification of several additional target organs for calcitriol has shown that this hormone regulates many more tissues and that its role in biology extends far beyond its classically regarded role in mineral metabolism. A rapidly increasing body of evidence suggests that calcitriol is involved with the hematolymphopoietic tissue, and new theoretical and clinical...References1. BRESLAUMCGUIREZERWEKHFRENKELPAK NJJEC. Hypercalcemia associated with increased serum calcitriol in three patients with lymphoma. Ann Intern Med. 1984;100:1-7. LinkGoogle Scholar2. MASONFRANKELCHANLISSNERPOSEN RTYDS. Vitamin D conversion by sarcoid lymph node homogenate. Ann Intern Med 1984;100:59-61. LinkGoogle Scholar3. TURNERHOWARDPUZASBAYLINKKNAPP RGJDD. Calvarial cells synthesize 1 α, 25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3. Biochemistry. 1983;22:1073-6. CrossrefMedlineGoogle Scholar4. URISTMCLEAN MF. Mast cells in bones. Surg Forum. 1956;7:590-9. Google Scholar5. YETGINOZSOYLU SS. 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Author, Article, and Disclosure InformationAffiliations: University of California, San Diego Veterans Administration Medical Center La Jolla, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited By1?,25-dihydroxyvitamin D3 inhibits rat liver ultrastructural changes in diethylnitrosamine-initiated and phenobarbital promoted rat hepatocarcinogenesisHepatic expression of regeneration marker genes following partial hepatectomy in the ratAll-trans and 9-cis retinoic acid enhance 1,25-dihydroxyvitamin D3-induced monocytic differentiation of U937 cellsLymphocyte subpopulations in children with vitamin D deficient ricketsDistribution of target cells for 1,25-dihydroxyvitamin D3 in the brain of the yellow bellied turtle Trachemys scriptaTreatment of acute myeloid leukemia in the elderly with low-dose cytarabine, hydroxyurea, and calcitriolSuspected distinct activation pathways of human lymphocytes induced by antilymphocyte globulin and anti-CD 3 monoclonal antibody result in different secretion of hematopoietic colony-stimulating activitiesEffects of Isolation on Interferon Production and Hematological and Immunological ParametersHypercalcemia and vitamin d metabolism in Hodgkin's disease. 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COHEN, M.D., T. KENNEY GRAY, M.D. 1 January 1984Volume 100, Issue 1Page: 144-146KeywordsBoneCalcitriolEndocrine systemHormonesKidneysVitamin D Issue Published: 1 January 1984 PDF DownloadLoading ...