tbuckley/cabot-search huggingface dataset:
Comparison of Electrocardiographic Criteria for the Detection of Cardiac Abnormalities in Elite Black and White Athletes
Authors: Nabeel Sheikh, Michael Papadakis, Saqib Ghani, Abbas Zaidi, Sabiha Gati, Paolo Emilio Adami, François Carré, Frédéric Schnell, Mathew Wilson, Paloma Avila, William McKenna, Sanjay Sharma
Journal: Circulation (2014)

Recent efforts have focused on improving the specificity of the European Society of Cardiology (ESC) criteria for ECG interpretation in athletes. These criteria are derived predominantly from white athletes (WAs) and do not account for the effect of Afro-Caribbean ethnicity or novel research questioning the relevance of several isolated ECG patterns. We assessed the impact of the ESC criteria, the newly published Seattle criteria, and a group of proposed refined criteria in a large cohort of black athletes (BAs) and WAs. Between 2000 and 2012, 1208 BAs were evaluated with history, examination, 12-lead ECG, and further investigations as appropriate. ECGs were retrospectively analyzed according to the ESC recommendations, Seattle criteria, and proposed refined criteria which exclude several specific ECG patterns when present in isolation. All 3 criteria were also applied to 4297 WAs and 103 young athletes with hypertrophic cardiomyopathy. The ESC recommendations raised suspicion of a cardiac abnormality in 40.4% of BAs and 16.2% of WAs. The Seattle criteria reduced abnormal ECGs to 18.4% in BAs and 7.1% in WAs. The refined criteria further reduced abnormal ECGs to 11.5% in BAs and 5.3% in WAs. All 3 criteria identified 98.1% of athletes with hypertrophic cardiomyopathy. Compared with ESC recommendations, the refined criteria improved specificity from 40.3% to 84.2% in BAs and from 73.8% to 94.1% in WAs without compromising the sensitivity of the ECG in detecting pathology. Refinement of current ECG screening criteria has the potential to significantly reduce the burden of false-positive ECGs in athletes, particularly BAs.
Lymphangioma of the Duodenum
Authors: H.H. Salata, J. Mercader, A. Navarro, J.M. Cortés, C. Gonzáles-Campos
Journal: Endoscopy (1984)

A case of lymphangioma of the duodenum is reported, and the literature pertinent to its pathology reviewed. This is the eleventh case reported, and the third in which the diagnosis has been made by endoscopy. The clinical and histological characteristics are important, on account of its presentation and its penetrating character into the neighbouring structures. The characteristics of this tumor seen during endoscopy are discussed.
Multiple Catheterization of the Right Side of the Heart
Authors: Hugh Chaplin
Journal: JAMA (1969)

<h3>To the Editor:—</h3> The authors share Dr. Smith's understandable curiosity concerning the nature of the patient's cardiac anomaly and would be most interested in the results of a second catheterization of the right side of the heart. However, we were mightily impressed with our patient's cardiorespiratory reserve, which far exceeded our own individually or as a relay team. There was no medical justification for repeating the studies, and try as we might, nowhere could we find that the number of research grants supporting a clinical investigation constituted an indication for cardiac catheterization.
Organization of Hospital Departments of Inhalation Therapy
Authors: William A. Yorzyk
Journal: JAMA (1968)

A survey of eight hospitals with functioning departments of inhalation therapy and a review of pertinent literature showed that basic fundamentals relating to the organization and administration of an inhalation therapy department in a general hospital include justification, organization, location and design, personnel, equipment, and records. It is recommended that the physician who contemplates the organization of a new department of inhalation therapy survey existing services in other hospitals and correlate his observations with the fundamentals presented here.
Diabetic Coma without Ketoacidosis
Authors: S. Shaz
Journal: BMJ (1964)

Tetanus Prophylaxis SIR,-Following the recent criticisms of anti-tetanus serum injections (30 November, p. 1360) this case may be of interest.A 53-year-old man suffering from chronic widespread psoriasis attended casualty with a cut hand caused by a tin-opener.He was given A.T.S. 1,500 units subcutaneously into his left upper arm after a negative intradermal test dose into his right upper arm.He was also started on a course of tetanus toxoid.Three days later the multiple psoriatic lesions of both fore- arms swelled, lost their scales, and became very irritant.Only the psoriatic areas of his fore- arms were affected-no other skin areas or psoriatic lesions were involved, and there was no systemic reaction.Four days later the affected areas were slowly returning to the state they were in before the injections.-I am, etc.,
PREVENTIVE EFFECT OF EXENATIDE TO ENDOTHELIAL DYSFUNCTION INDUCED BY ISCHEMIA-REPERFUSION INJURY VIA ADP K CHANNELS
Authors: Sang Jin Ha, Weon Kim, Jong Shin Woo, Tae-kyung Yu, Soo Joong Kim, Woo-Shik Kim, Myeong Kon Kim, Kwon Sam Kim
Journal: Journal of the American College of Cardiology (2010)
OBESITY PARADOX AND ANGINA FREQUENCY IN PATIENTS PRESENTING WITH ACUTE MYOCARDIAL INFARCTION
Authors: Praneet Sharma, Donna Buchanan, Philip Jones, Stacie Daugherty, Faraz Kureshi, Natalie Jayaram, Javier Valle, Eric Dean Merrill, Fengming Tang, John Spertus
Journal: Journal of the American College of Cardiology (2014)
Breast Implants — Protection or Paternalism?
Authors: Marcia Angell
Journal: New England Journal of Medicine (1992)

IN this issue of the Journal, Dr. David A. Kessler, the commissioner of the Food and Drug Administration, presents his rationale for removing silicone-gel breast implants from the market.1 Each year about 150,000 women receive these implants — 80 percent for the purpose of breast augmentation and almost all the others for reconstruction after mastectomy for cancer. Kessler reminds us that under the 1976 Medical Device Amendments to the federal Food, Drug and Cosmetic Act, manufacturers are required to demonstrate the safety and effectiveness of drugs and devices. Since breast implants were already on the market in 1976, their . . .
Electrocardiographic Abnormalities in a Murine Model Injected With IgG From Mothers of Children With Congenital Heart Block
Authors: Jay A. Mazel, Nabil El-Sherif, Jill Buyon, Mohamed Boutjdir
Journal: Circulation (1999)

Background —It is a widely held view that congenital heart block (CHB) is caused by the transplacental transfer of maternal autoantibodies (anti-SSA/Ro and/or anti-SSB/La) into the fetal circulation. To test this hypothesis and to reproduce human CHB, an experimental mouse model ( BALB/c) was developed by passive transfer of human autoantibodies into pregnant mice. Methods and Results —Timed pregnant mice (n=54) were injected with a single intravenous bolus of purified IgG containing human anti-SSA/Ro and anti-SSB/La antibodies from mothers of children with CHB. To parallel the “window period” of susceptibility to CHB in humans, 3 groups of mice were used: 8, 11, and 16 days of gestation. Within each group, we tested 10, 25, 50, and 100 μg of IgG. At delivery, ECGs were recorded and analyzed for conduction abnormalities. Bradycardia and PR interval were significantly increased in 8-, 11-, and 16-day gestational groups when compared with controls ( P &lt;0.05). QRS duration was not significantly different between all groups. Antibody levels measured by ELISA in both mothers and their offspring confirmed the transplacental transfer of the human antibodies to the pups. Conclusions —The passive transfer model demonstrated bradycardia, first-degree but not complete atrioventricular block in pups. The greater percentage and degree of bradycardia and PR prolongation in the 11-day mouse group correlates with the “window period” of susceptibility observed in humans. The high incidence of bradycardia suggests possible sinoatrial node involvement. All together, these data provide relevant insights into the pathogenesis of CHB.
Specific Avidity of the Heart Muscle to Absorb and Store Epinephrine and Norepinephrine
Authors: W. RAAB, W. GIGEE
Journal: Circulation Research (1955)

Circulating epinephrine and norepinephrine are avidly absorbed and stored by the heart muscle but not by skeletal muscle of dogs. Stimulation of the cardiac sympathetic nerves augments myocardial norepinephrine but not epinephrine. Sympatholytic drugs do not diminish, some even increase active catecholamines in heart muscle. The results explain a number of pathophysiologic conditions briefly enumerated.
Ocular involvement in IgA-epidermolysis bullosa acquisita
Authors: J.W. Bauer, H. Schaeppi, D. Metze, W. Muss, G. Pohla-Gubo, R. Hametner, J. Ruckhofer, G. Grabner, H. Hintner
Journal: British Journal of Dermatology (1999)

Epidermolysis bullosa acquisita (EBA) is an autoimmune bullous disease with frequent ocular involvement, but visual loss is rare. In contrast, EBA patients with predominant IgA autoantibodies more frequently develop severe ocular involvement, which tends to be refractory to therapy. We report two patients with 'IgA-EBA' with ocular involvement. Both initially presented with a generalized bullous disease, and direct immunofluorescence microscopy demonstrated IgA in the basement membrane zone of the skin, and in the conjunctiva and cornea of patient 1. On salt-split patient skin, IgA was found predominantly on the dermal side of the artificial split in both patients. Direct immunoelectron microscopy demonstrated IgA below the lamina densa in close association with the anchoring fibrils in both patients. In patient 1, who had a prolonged course of the disease, the skin disorder responded well to treatment with cyclosporin, but the ocular involvement ended in bilateral blindness despite repeated surgical treatment. In patient 2, the blister formation and scarring conjunctivitis was stopped by a combination of prednisolone and colchicine. These patients show that in subepithelial blistering diseases, early delineation of disease nosology is critical to detect subtypes with severe ocular involvement such as 'IgA-EBA'. In addition, colchicine may be a valuable alternative in the treatment of EBA with ocular involvement.
Management of Urinary Incontinence in Women
Authors: Jayna M. Holroyd-Leduc, Sharon E. Straus
Journal: JAMA (2004)

Urinary incontinence, defined as involuntary loss of urine, is a common health problem among women. The prevalence rate is between 12% and 55% for having ever experienced urinary incontinence. It is associated with poor self-rated health, impaired quality of life, social isolation, and depressive symptoms. However, physicians are usually not the ones to initiate discussion about incontinence with their patients. We present clinical cases to illustrate common scenarios in which a physician may be able to help a female patient manage her urinary incontinence by specifically addressing associated factors and offering treatments to improve or possibly even cure her symptoms. Several evidence-based effective nonpharmacological, pharmacological, and surgical treatment options are outlined.
Alterations in circulating thyroid hormones and thyrotropin in euthyroid patients with Graves' disease after total thyroidectomy: Comparison between responders and nonresponders to TSH-releasing hormone
Authors: Hajime Tamai, Kenji Mori, Sunao Matsubayashi, Yoshihiko Hirota, Akira Kobayashi, Fumio Matsuzuka, Kanji Kuma, Lindy F. Kumagai, Shigenobu Nagataki
Journal: Metabolism (1985)
Tragic Events of April 1996
Authors: Katherine E. Tiller
Journal: Annals of Internal Medicine (2001)

Letters6 March 2001Tragic Events of April 1996Katherine E. Tiller, MBBSKatherine E. Tiller, MBBSSalem, VA 24153 (Tiller)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-5-200103060-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Coulehan (1) wrote a touching and dramatic account of the tragic mass shooting at Port Arthur in Tasmania in 1996. However, I firmly disagree with his conclusions.I am an Australian and was also horrified by the mass murder, but gun control is definitely not the answer. Although the firearm-related death rate decreased in Australia from 4.8 deaths per 100 000 population in 1980–1982 to 2.6 deaths in 1995, the Australian government imposed a 1% tax on the Australian people in 1996 to buy back guns (2). However, instead of reducing the crime rate, homicides increased by ...References1. Coulehan J. The tragic events of April 1996. Ann Intern Med. 2000;132:911-3. [PMID: 0010836919] LinkGoogle Scholar2. Injury Prevention and Control 1996. Australian Bureau of Statistics. Available at www.abs.gov.au. Accessed June 2000. Google Scholar3. Richardson HL. Going Down, Down Under. Gun Owners of America. Available at www.gunowners.org. Accessed June 2000. Google Scholar Author, Article, and Disclosure InformationAuthors: Katherine E. Tiller, MBBSAffiliations: Salem, VA 24153 (Tiller) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Tragic Events of April 1996 Jack Coulehan Tragic Events of April 1996 Harry J. Driedger Tragic Events of April 1996 Stephen Sandroni Tragic Events of April 1996 Jack Coulehan Tragic Events of April 1996 Kenneth J. Simcic Tragic Events of April 1996 Robert Starkenburg Metrics 6 March 2001Volume 134, Issue 5Page: 424-425KeywordsAssaultCrimeDeath ratesHomicideLegislationTaxes ePublished: 6 March 2001 Issue Published: 6 March 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
THE RELATIONSHIP OF NEUROLOGY TO PREVENTIVE MEDICINE
Authors: JOSEPH COLLINS
Journal: JAMA (1910)

The neurologist is concerned with a branch of inter- nal medicine which at first sight does not appear to have much relationship to public health, but, in reality, not only does such relationship exist, but it is a very inti- mate one.Though public health seems to concern itself with sanitation and pure food, epidemics and health-men- acing noises, public hygiene is, in reality, public educa- tion.Its aim should be to teach people, not only how to live long, but how to live happily, and my first contention is that, until the present time, preventive medicine has concerned itself exclusively with the former, whereas, if the object and aim of life is the pursuit of happiness, personal and general, preventive medicine is but half accomplishing its purpose.Following its principles, we direct our efforts to stamping out diseases which kill, leaving unnoticed and unattacked those which maim and incapacitate.The victims of these often find life insupportable, and they not only menace the happiness of their families, but stain the escutcheon by the crime of self- destruction.I shall attempt a discussion of the relationship of "('urology to public health under two captions: first, our obvious duty in dealing with certain infectious dis¬ eases of the nervous system, and second, our privilege in attempting to overcome certain incapacitating mental states.
How Much Will U.S. Medicine Change in the Decade Ahead?
Authors: ELI GINZBERG
Journal: Annals of Internal Medicine (1978)

A New York University Honors Program Lecture During the past 12 years health care services have been increasingly used by low-income families, largely as a consequence of infusion of more funds into the health care system. The number of persons employed in health care has gone up along with an expanded governmental role. Present governmental concerns are focused on cost and the relation of public attitudes to needs for, and costs of, a system of national health insurance. In the near future, medical services are not likely to be expanded, and various costly services may be contracted. The number of physicians will go up but the fraction in solo practice will decline. Patterns of physician maldistribution are not likely to be changed substantially. Costs will continue to go up, and government and other third-party payers will strive to control them. A comprehensive form of national health insurance will not come soon, and the public will become increasingly aware of the limits to which health care can improve their lives.
Visceral leishmaniasis presented with Evans syndrome: A case report
Authors: Bulent Alioglu, Zekai Avci, Emel Ozyurek, Namik Ozbek
Journal: American Journal of Hematology (2007)

Successful desensitization in a patient with Lenalidomide hypersensitivityTo the Editor: A 48-year-old woman being treated with lenalidomide for kappa light chain multiple myeloma presented with severe rash associated with urticaria, pruritus, and fever.The patient was initially diagnosed with Stage II breast cancer (ER/PR+ and HER-2neu negative) in 2003 and underwent treatment with lumpectomy followed by four cycles of Adriamycin and Cyclophosphamide followed by two cycles of Paclitaxel and then switched to an additional two cycles of Taxotere because of poor tolerance.This was followed by radiation therapy and hormonal therapy.Two years later she was diagnosed with multiple myeloma.As a result of her negative prior experience with chemotherapy and steroids she refused treatment with either and was therefore initially treated with single agent thalidomide.Thalidomide treatment had to be discontinued due to a similar reaction manifesting with severe rash, urticaria, and pruritus, which was thought to be a Type I (IgE mediated) hypersensitivity reaction.When lowered to 50 mg the patient continued to experience side effects necessitating its permanent discontinuation.She was subsequently treated with bortezomib which had to be discontinued secondary to increasing neuropathy.Lenalidomide treatment at the standard dose of 25 mg resulted in the reaction described above which was similar to the reaction she developed on thalidomide, which is not surprising given the structural similarities between the two drugs.The patient was subsequently referred to Allergy-Immunology for desensitization in August 2006.The patient was desensitized using the protocol shown in Table I.In brief, lenalidomide was dissolved in normal saline and diluted to concentrations of 0.025, 0.25, and 2.50 mg/ml.She was given gradually increasing strengths to take orally at 15-to 20-min interval.During the desensitization she had her blood pressure, heart rate, temperature, pulse oximetry, and peak flow monitored.She tolerated the escalating doses with no reaction and was subsequently begun on lenalidomide 15 mg daily, and continues to tolerate daily continuous dosing with no evidence of recurrent hypersensitivity.The patient remains asymptomatic in a PR as defined by the International Working Group Uniform Response Criteria, and also remains free from any evidence of recurrent breast cancer.This represents the first case of successful desensitization to lenalidomide that we are aware of.Since this drug has become an integral component of multiple myeloma therapy this represents an important option for patients who otherwise would not be able to tolerate lenalidomide.
Research Contributions to Combination Chemotherapy
Authors: Emil J Freireich
Journal: JAMA (1972)

Beginning with my appointment at the Clinical Center of the National Cancer Institute in 1955, I have devoted my major research work to investigation of patients with acute leukemia. During the first ten-year period (1955-1965) I was responsible for an acute leukemia service, where 477 patients with acute leukemia were studied and received definitive therapy. In 1965, I moved to the University of Texas M. D. Anderson Hospital and Tumor Institute at Houston as chief of research hematology, where I have continued clinical research, particularly in adults with acute leukemia. To date, more than 500 additional patients have been studied and treated. As a participant in the first cooperative clinical trial in acute leukemia, I had a role in developing the first clinical study demonstrating that the antileukemic activity of a drug can be detected and evaluated quantitatively, by its ability to prolong the duration of remission, when given to
TCT-473 Efficacy and safety of abciximab administration in contemporary primary percutaneous coronary intervention
Authors: Julio García-Tejada, Jurado-Roman Alfonso, Carolina Granda, Agustin Albarran, Felipe Henandez, M. Teresa Velazquez, Roberto Martin-Asenjo, Belen Rubio, Sandra Mayordomo, Juan C. Tascon
Journal: Journal of the American College of Cardiology (2014)
HURRICANE KATRINA AND MYOCARDIAL INFARCTION INCIDENCE: SEVEN YEARS AFTER THE STORM
Authors: Matthew N. Peters, Kevin Deandrade, Henry Quevedo Diaz, Burchett R. Andrew, Sumit Tiwari, Kanwar Singh, Thomas A. Turnage, Edmond N. Fomunung, Holly Gonzales, Sudesh Srivastav, Patrice Delafontaine, Anand Irimpen
Journal: Journal of the American College of Cardiology (2014)
DEVELOPMENT OF AN OBSERVATIONAL TOOL TO ASSESS QUALITY OF EXERCISE PERFORMANCE BY PARTICIPANTS IN A NEUROMUSCULAR INJURY PREVENTION PROGRAM
Authors: L Fortington, CF Finch, A Donaldson, T Lathlean, J Cook, B Gabbe, D Lloyd, W Young
Journal: British Journal of Sports Medicine (2014)

Background In determining the effectiveness of sports injury prevention programs (IPP), an assessment of program fidelity is needed. This includes considering whether the intervention was delivered and adhered to as it was intended. Evaluation of program fidelity prevents incorrect conclusions being made about the effects of an IPP and can provide information on why it was successful, or not. Program fidelity for IPPs in sport has generally been limited to self-reported measures around frequency of participation. However, for exercise-based IPPs, performing the exercises as they were originally prescribed is important to maximise injury prevention benefits. Therefore, observing the actual exercise performance could give important insight when evaluating overall IPP fidelity. Objective The aim of this study was to develop an observational tool for exercise-based IPPs and assess its inter-rater reliability. This was trialled in the context of FootyFirst, an IPP in Australian Football. Design The essential performance criteria of each FootyFirst exercise were described in terms of their technique, volume and intensity, in line with exercise prescription guidelines. The expert FootyFirst development team were consulted until consensus was reached on details of each exercise. Each criterion was evaluated by observing player performance and responding with a yes/no answer. Setting Community Australian football clubs. Participants Players participating in FootyFirst as part of regular training; two independent raters. Main outcome measurements Inter-rater reliability of tool and correct performance of FootyFirst exercises. Results The observational tool was trialled at eight clubs for 70 observations. The raters agreed on 61 observations (K=0.718, P&lt;.001; substantial agreement), of which 41(67%) scored yes for all performance criteria (technique, volume and intensity), indicating the exercise was performed as prescribed. Conclusions The FootyFirst Observational Tool has high inter-rater reliability. This can be used to monitor the quality of exercise performance when assessing overall program fidelity.