Cells Metabolizing Vitamin D
Authors: Johan Auwerx, Roger Bouillon, Jan Ceuppens
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 April 1984Cells Metabolizing Vitamin DMYRON S. COHEN, M.D., T. KENNEY GRAY, M.D.MYRON S. COHEN, M.D.Search for more papers by this author, T. KENNEY GRAY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-4-611_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the reports by Breslau and associates (1) and Mason and coworkers. (2) regarding vitamin D and its relationship to the hypercalcemia of lymphomas and of sarcoidosis. We have recently reported (3) that phagocytic cells including human neutrophils and monocytes metabolize calcifediol to three distinct metabolites. One of these peaks could easily be misidentified as calcitriol by several commonly used chromatographic systems. Perhaps this novel metabolite contributed to the mild elevations of calcitriol reported in the three patients with lymphoma (1).The metabolism of calcifediol by a lymph node removed from a patient with...References1. BRESLAUMCGUIREZERWEKHFRENKELPAK NJJEC. Hypercalcemia associated with increased serum calcitriol levels in three patients with lymphoma. Ann Intern Med. 1984;100:1-7. LinkGoogle Scholar2. MASONFRANKELCHANLISSNERPOSEN RTYDS. Vitamin D conversion by sarcoid lymph node homogenate. Ann Intern Med. 1984;100:59-61. LinkGoogle Scholar3. COHENGRAY MT. Phagocytic cells metabolize 25-hydroxyvitamin D3 in vitro. Proc Natl Acad Sci USA. 1984. (In press). CrossrefGoogle Scholar4. ADAMSSHARMAGACADSINGER JPMF. Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis. J Clin Invest. 1983;72:1856-60. CrossrefMedlineGoogle Scholar5. WARNER M. 25-hydroxyvitamin D hydroxylation: evidence for a dioxygenase activity of solubilized renal mitochondrial cytochrome. J Biol Chem. 1983;258:11590-3. CrossrefMedlineGoogle Scholar1. BRESLAUMCGUIREZERWEKHFRENKELPAK NJJEC. Hypercalcemia associated with increased serum calcitriol in three patients with lymphoma. Ann Intern Med. 1984;100:1-7. LinkGoogle Scholar2. MASONFRANKELCHANLISSNERPOSEN RTYDS. Vitamin D conversion by sarcoid lymph node homogenate. Ann Intern Med. 1984;100:59-61. LinkGoogle Scholar3. MANOLAGASDEFTOS SL. The vitamin D endocrine system and the hematolymphopoietic tissue. Ann Intern Med. 1984;100:144-6. LinkGoogle Scholar4. GRAYMADDUXLESTERWILLIAMS TFGM. Rodent macrophaged matabolize 25-hydroxyvitamin D3 in vitro. Biochem Biophys Res Commun. 1982;109:723-9. CrossrefMedlineGoogle Scholar5. ADAMSSHARMAGACADSINGER JOMF. Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis. J Clin Invest. 1983;72:1856-60. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of North Carolina School of Medicine Chapel Hill, NC 27514 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1984Volume 100, Issue 4Page: 611-612KeywordsCalcitriolHypercalcemiaLymph nodesLymphomaMetabolitesMonocytesNeutrophilsPhagocytesSarcoidosisVitamin D Issue Published: 1 April 1984 PDF DownloadLoading ...