tbuckley/cabot-search huggingface dataset:
Familial restrictive cardiomyopathy caused by a missense mutation in the desmin gene: possible role of apoptosis in disease pathogenesis
Authors: Zeev Perles, Nell E. Bowles, Matteo Vatta, Shinawe Jimenez, Jacqueline Szmuszkovicz, Yassemi Capetanaki, Jeffrey A. Towbin
Journal: Journal of the American College of Cardiology (2002)
Ito Cells Are Liver-Resident Antigen-Presenting Cells for Activating T Cell Responses
Authors: Florian Winau, Guido Hegasy, Ralf Weiskirchen, Stephan Weber, Cécile Cassan, Peter A. Sieling, Robert L. Modlin, Roland S. Liblau, Axel M. Gressner, Stefan H.E. Kaufmann
Journal: Immunity (2007)
DICEPHALUS WITH TWO COMPLETE SPINES
Authors: C. A. Cibelius
Journal: JAMA (1922)

A monster having two heads with a varying degree of duplication of the rest of the body is termed dicephalus. The etiology of such monsters is unknown. De Lee<sup>1</sup>states that they come from one ovum and are developed from one germinal vesicle. Entrance of more than one spermatozoid is not the cause, because eggs so impregnated usually die. None of such cases have delivered spontaneously, and only a few have lived more than a short time. In vertex presentations, after failure of forceps delivery, version and extraction have been employed and in four cases decapitation, and then version. The breech presentations have been delivered by maniplation and traction. Beach<sup>2</sup>recently reported a case of dicephalus with a review of some of the cases. <h3>REPORT OF CASE</h3> The mother, Mrs. H., aged 20, a secundipara, was admitted to Rockford Hospital at 8 p. m., July 10, 1921. The
Severe mononucleosis in a girl with progression to lymphoma–Epstein Barr Virus (EBV)-associated lymphoproliferative disease (LPD) that mimics X-linked lymphoproliferative disease (XLPD)
Authors: J.T. Kayser, H. Heslop, K. McClain, M.K. Dishop, S. May, L.M. Noroski
Journal: Journal of Allergy and Clinical Immunology (2005)
Ga-67 Citrate Myocardial Uptake in a Patient with AIDS, Toxoplasmosis, and Myocarditis
Authors: DAVID S. MEMEL, ANDREW J. DeROGATIS, DANIEL C. WILLIAM
Journal: Clinical Nuclear Medicine (1991)

A 38-year-old man with AIDS presented with fever of unknown origin, splenomegaly, anemia, and thrombocytopenia. Admission laboratory data revealed a positive toxoplasmosis titer in the blood. The initial chest x-ray showed small bilateral pleural effusions, a normal cardiac silhouette, no infiltrates, and no interstitial edema. Ga-67 imaging revealed markedly abnormal uptake in the myocardium. A diagnosis of toxoplasmosis myocarditis was made based on laboratory and imaging data. The patient was treated for toxoplasmosis. No myocardial uptake of tracer was demonstrated on a follow-up Ga-67 scan, performed after completion of treatment for toxoplasmosis.
“Obfuscation” in Medical Writing
Authors: F.J. Ingelfinger
Journal: New England Journal of Medicine (1976)

When Dr. Michael Crichton castigated the pedantry and obscurity of medical writing,1 some 16 letter writers promptly shouted, "Amen," but eight argued that the Crichton piece was itself far from a model of lucidity and conciseness. (See this week's correspondence.) Unfortunately, Dr. Crichton's charges cannot be gainsaid, but the causes of inadequate medical prose warrant broader consideration. Essentially, there are three, not mentioned by either Crichton or the correspondents: massive infiltration of language by the words of an extravagant technology, authorship by committee, and the failure — even inability! — of doctors to read.Although Osler used a somewhat pretentiously ornate . . .
Dr. C. Henri Leonard replies to Congressman Corliss, who evidently misrepresents a large number of his constituents.
Authors: Jno. B. Corliss.
Journal: JAMA (1898)

Detroit, Mich., June 10, 1898. C.Henri Leonard, M.D., Leonard Block, Detroit, Mich. <h3>Dear Sir:</h3> —I am in receipt of your letter with a copy of resolution, and I regret that the medical fraternity should act so<i>hastily</i>and without proper investigation. In the first place, I never introduced a bill in Congress of any name or nature, touching the subject embraced in your resolution. Secondly, the Hepburn bill, to which you probably refer, I reported to the House by order of the Committee of which I am a member, thereby performing thedutydevolving upon me as such member. Thirdly, this measure simply enables the Marine-Hospital service to do more efficiently the work now being done, and does not materially extend the scope of that department. Fourthly, the measure which the medical fraternity are advocating has not been acted upon by the Committee for the reason that, if adopted,
Immunological evaluation of harvested stem cells obtained by leukapheresis after chemotherapy
Authors: G. Teixeira, B. Lenormand, P. Jean, D. Fardoun, E. Sumereau‐Dassin, D. Bastit, H. Tilly, H. Piguet, M. Monconduit, J. P. Vannier
Journal: American Journal of Hematology (1992)

Abstract Some patients suffering from malignancies may benefit of myeloablative chemotherapy followed by hematological reconstitution with autologous peripheral blood reinfusion. A quick evaluation of the number of hematopoietic progenitors present in leukapheresis blood samples is necessary to ensure the collection of a sufficient number of these cells. A study was performed on a series of 25 leukapheresis following initial chemotherapy. The number of granulomonocytic colony‐forming unit (CFU‐GM) and the number of CD34+ cells were evaluated simultaneously, in each sample. Results have shown a relatively strong linear correlation between both methods of evaluation of hematopoietic progenitors, suggesting that immunophenotyping could be a useful method to estimate the number of progenitors.
Effects of concentration on in vivo absorption of a peptide containing protein hydrolysate.
Authors: J E Hegarty, P D Fairclough, K J Moriarty, M J Kelly, M L Clark
Journal: Gut (1982)

Amino acid absorption from a peptide-containing protein hydrolysate and an equivalent amino acid mixture over a range of concentrations of the two--such as is thought to be found in the normal intestine after a meal--has been studied using a jejunal perfusion technique in man. The relative rates of amino acid absorption from the protein hydrolysate and amino acid mixture varied markedly with concentration, demonstrating that the global hypothesis that peptides confer an advantage in amino acid absorption in vivo is too simple. There is a highly significant correlation between amino acid absorption and the concentrations of amino acid in the perfusate, whether this contained amino acid or protein hydrolysate, suggesting that, under these experimental conditions at least, the presence of distinct amino acid and peptide transport systems is relatively unimportant. Doubt is thus cast upon suggestions derived from previous intestinal perfusion experiments that intact peptide transport may be nutritionally significant in man.
Standard error of the mean
Authors: P. Sedgwick
Journal: BMJ (2010)

Researchers used a cluster randomised controlled trial design to assess the effectiveness of a multicomponent physical activity programme on the physical and psychological health of young schoolchildren.1 For each child, the skinfold thickness was measured at four places (triceps, biceps, subscapular, and suprailiacal), and the measurements were added together to provide a marker of obesity. 

At the end of the study period of one school year, the intervention group (n=297) had a mean skinfold thickness of 32.50 mm (SEM=0.85 mm), compared with 33.70 mm (SEM=1.20 mm) in the control group (n=205). SEM, sometimes shortened to SE, is the abbreviation for standard error of the …
Is 2,3,7,8-TCDD (dioxin) a carcinogen for humans?
Authors: S M Ayres, K B Webb, R G Evans, J Mikes
Journal: Environmental Health Perspectives (1985)

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has suddenly become the focal point of controversy over the relationship of chemical waste to human health. Specific concern exists regarding its potential association with human malignancy. Subcellular, cellular, and whole-animal experiments suggest that TCDD exerts much of its activity by inducing enzymes that protect the intact organism from the assault of environmental contamination. TCDD is a potent inducer of aryl hydrocarbon hydroxylase, although wide variations between species do exist. Conventional tests for mutagenicity have produced conflicting results. Animal experiments have shown the development of tumors following chronic low level ingestion of TCDD. The human evidence regarding the potential carcinogencity of TCDD comes from occupational, military and environmental exposures. Several studies have come out of Sweden suggesting an association between sarcoma and exposure to herbicides. Although there is little solid evidence that 2,3,7,8-TCDD produces substantial chronic disability or premature death in man, a significant body of experimental evidence for its carcinogenicity makes it likely that a small number of human malignancies may be due to its action. Since 2,3,7,8-TCDD is an unwanted contaminant it could be eliminated with little measurable consequence.
RISK ASSESSMENT FOR OSTEOPOROSIS AND CORONARY ATHEROSCLEROSIS USING CORONARY ARTERY CALCIUM SCANS AMONG MAINTENANCE HEMODIALYSIS PATIENTS
Authors: Irfan Zeb, Frishta Ataie, Ronney Shantouf, Dong Li, Song Shou Mao, Jennie Jing, Kamyar Kalantar-Zadeh, Matthew J. Budoff
Journal: Journal of the American College of Cardiology (2011)
Maintenance of Certification
Authors: Robert B. Copeland
Journal: Annals of Internal Medicine (2015)

Letters6 January 2015Maintenance of CertificationRobert B. Copeland, MDRobert B. Copeland, MDFrom West Georgia Physicians, LaGrange, Georgia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5040-4 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Centor and colleagues' editorial (1) and multiple ACP mailings, e-mails, and telephone calls have made me well aware that I am not alone in my concern about the ABIM's position on MOC. The current generic ABIM statement for those internists without time-limited certification is “certified, not meeting maintenance-of-certification requirements.” The ABIM does not know what those of us who consider professionalism and lifelong scholarship a critical personal obligation may be doing. I consider the statement an insult. Patients, employers, and insurers may well read it as “unfit to practice medicine”!I have successfully taken 5 ABIM certification ...Reference1. Centor RM, Fleming DA, Moyer DV. Maintenance of certification: beauty is in the eyes of the beholder [Editorial]. Ann Intern Med. 2014;161:226-7. [PMID: 24821483] doi:10.7326/M14-1014 LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Robert B. Copeland, MDAffiliations: From West Georgia Physicians, LaGrange, Georgia.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterest Forms.do?msNum=L14-0502. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMaintenance of Certification: Beauty Is in the Eyes of the Beholder Robert M. Centor , David A. Fleming , and Darilyn V. Moyer Maintenance of Certification: Beauty Is in the Eyes of the Beholder Robert M. Centor , David A. Fleming , and Darilyn V. Moyer Maintenance of Certification Michael Kelley Maintenance of Certification Edward Ringel Maintenance of Certification Donald Trainor Maintenance of Certification Leonard Johnson Maintenance of Certification Antoinette Spevetz Maintenance of Certification Robert M. Centor , David A. Fleming , and Darilyn V. Moyer Maintenance of Certification Michael Kelley Maintenance of Certification Leonard Johnson Maintenance of Certification Robert M. Centor , David A. Fleming , and Darilyn V. Moyer Maintenance of Certification Antoinette Spevetz Maintenance of Certification Donald Trainor Maintenance of Certification Edward Ringel Metrics 6 January 2015Volume 162, Issue 1Page: 78KeywordsConflicts of interestDisclosureHealth careTouch ePublished: 6 January 2015 Issue Published: 6 January 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Prevention of Poisoning
Authors: Stuart A. Copans
Journal: JAMA (1976)

<h3>To the Editor.—</h3> Dr Arena's series of articles on poisoning (232:1272, 233:358,900,1975) are a valuable addition to the files of practicing physicians; however, one important consideration that should play an important part in the follow-up of poisoning in children was not mentioned by Dr Arena. This is the association of "accidental" poisoning in children with family disturbance. Sobel and Margolis,<sup>1</sup>in a study of repetitive poisoning in children, found that repetitive poisoning was not related to environmental hazard or lack of parental supervision, but rather to marital tension and a tense and distant family atmosphere. These findings were confirmed by a more elaborate prospective study, in which it was again found that accidental poisoning in children bears no relationship to home safety as measured by the quantity, toxicity, and availability of poisonous substances in their homes,<sup>2</sup>and that accidental poisoning was intimately related with parental psychopathology and disturbed
<i>Dido, Queen of Carthage</i>
Authors: Thomas B. Cole
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HMO Financial Incentives and Informed Consent
Authors: William H. Anderson
Journal: JAMA (1988)

<h3>To the Editor.—</h3> The recent appearance of health maintenance organizations (HMOs) and other systems of managedcare provision has begun to stimulate concern over conflicts of interest between physicians and their patients. Ethical standards in this area will require further enhancement as political and economic pressures and constraints become more intrusive.<sup>1</sup> The ethical ideal would be best approached by removing all financial incentives from the medical decision process. It is difficult in practice to do this, since physicians and managers earn their livings making these decisions and must be compensated for their time. A method of financing that encourages neither too much nor too little care has yet to be invented. The rapid growth of HMO enrollment over the past four years appears to be slowing as issues of quality and access begin to be raised. As HMOs are in a highly competitive environment now, pressures to enlist new health
Current Studies in Haematology and Blood Transfusion. Volume 62. Hepatitis C Virus
Authors: M THURSZ
Journal: Gut (1998)

Current Studies in Haematology and Blood Transfusion. Volume 62. Hepatitis C Virus. 2nd edition. Edited by Reesink HW. (Pp 270; $172.25.) Basel: Karger, 1998. ISBN 3-8055-6542-9.

In just under a decade since the hepatitis C virus was first discovered the proliferation of research publications has been overwhelming. Although this is an appropriate reflection of the prevalence and clinical importance of the disease it has unfortunately created a confusing situation for clinicians and scientists outside the field. As a hepatologist I tend to feel that hepatitis …
Nerve mediated relaxation of the human internal anal sphincter: the role of nitric oxide.
Authors: T O'Kelly, A Brading, N Mortensen
Journal: Gut (1993)

The aim of this study was to determine if nitric oxide (NO) is the non-adrenergic, non-cholinergic neurotransmitter, released by enteric inhibitory nerves, which mediates relaxation of the human internal anal sphincter. Isolated muscle strips were mounted for isometric tension recording in superfusion organ baths. Sodium nitroprusside, an exogenous donor of NO, relaxed the strips in a concentration dependent manner. In the presence of atropine and guanethidine, transmural field stimulation produced tetrodotoxin sensitive relaxations, which were inhibited in a dose dependent and enantiomer specific manner by antagonists of NO synthase; completely by L-nitroarginine and partially by L-N-monomethyl arginine. The effect of these antagonists was reversed by L-arginine but not D-arginine. Oxyhaemoglobin, a scavenger of nitric oxide, also abolished the relaxations but methaemoglobin had no such effect. These results strongly suggest that NO is, or is very closely associated with, the non-adrenergic, non-cholinergic neurotransmitter mediating neurogenic relaxation of the human internal anal sphincter.
Involvement of activated transcriptional process in efficient gene transfection using unmodified and mannose-modified bubble lipoplexes with ultrasound exposure
Authors: Keita Un, Shigeru Kawakami, Yuriko Higuchi, Ryo Suzuki, Kazuo Maruyama, Fumiyoshi Yamashita, Mitsuru Hashida
Journal: Journal of Controlled Release (2011)
Indicators of Increased Risk for Peanut Sensitization/Likely Allergy among 3-15 Month Olds at Time of Entry to an Observational Study (CoFAR) of Food Allergy
Authors: S SICHERER, D STABLEIN, S JONES, R WOOD, A BURKS, A LIU, D FLEISCHER, D LEUNG, J ULLAH, R LINDBLAD
Journal: Journal of Allergy and Clinical Immunology (2008)
Peak Flow Monitoring for Guided Self-management in Childhood Asthma
Authors: Diane Wensley, Mike Silverman
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

We asked whether the addition of PEF recordings to a symptom-based self-management plan improved outcome in school children with asthma. In an open-randomized, parallel-group, controlled trial, we studied children aged 7-14 years with moderate asthma. After a 4-week run-in, 90 children were randomized to receive either PEF plus symptom-based management or symptom-based management alone for 12 weeks. Thresholds for action based on PEF were 70% of best (for increasing inhaled steroids) and 50% of best (for commencing prednisolone). Children were asked to perform twice-daily spirometry at home (using an electronic recording spirometer that revealed only PEF to the study group alone) and to record a symptom diary. The mean daily symptom score was the main outcome. There were no differences between groups in mean symptom score or in spirometric lung function, PEF, quality of life score, or reported use of health services over 12 weeks. During acute episodes, children responded to changes in symptoms by increasing their inhaled steroids at a mean value of PEF of greater than 70% of best so that overall PEF did not contribute to this important self-management decision. Knowledge of PEF did not enhance self-management even during acute exacerbations.
516 NEW PROTECTIVE STRATEGIES AGAINST COLD ISCHEMIA-REPERFUSION INJURY IN STEATOTIC AND NON-STEATOTIC LIVERS USING TROPHIC FACTOR AS ADDITIVE TO UW SOLUTION: IS THERE A DIFFERENCE
Authors: M.A. Zaouali, S. Padrissa-Altês, I. Alfany-Fernandez, J. Roselló-Catafau
Journal: Journal of Hepatology (2011)
A new method for noninvasive estimation of ventricular septal defect shunt flow by Doppler color flow mapping: Imaging of the laminar flow convergence region on the left septal surface
Authors: Valdir A. Moises, Benedito C. Maciel, Lisa K. Hornberger, Azucena Murillo-Olivas, Lilliam M. Valdes-Cruz, David J. Sahn, Robert G. Weintraub
Journal: Journal of the American College of Cardiology (1991)
High resolution computed tomographic assessment of asbestosis and cryptogenic fibrosing alveolitis: a comparative study.
Authors: N al-Jarad, B Strickland, M C Pearson, M B Rubens, R M Rudd
Journal: Thorax (1992)

BACKGROUND: The aim of this study was to compare the distribution and configuration of lung opacities in patients with cryptogenic fibrosing alveolitis and asbestosis by high resolution computed tomography. METHODS: Eighteen patients with cryptogenic fibrosing alveolitis and 24 with asbestosis were studied. Two independent observers assessed the type and distributions of opacities in the upper, middle, and lower zones of the computed tomogram. RESULTS: Upper zone fibrosis occurred in 10 of the 18 patients with cryptogenic fibrosing alveolitis and in six of the 24 patients with asbestosis. A specific pattern in which fibrosis was distributed posteriorly in the lower zones, laterally in the middle zones, and anteriorly in the upper zones was seen in 11 patients with cryptogenic fibrosing alveolitis and in four with asbestosis. Band like intrapulmonary opacities, often merging with the pleura, were seen in 19 patients with asbestosis but in only two with cryptogenic fibrosing alveolitis. Areas with a reticular pattern and a confluent or ground glass pattern were the commonest features of cryptogenic fibrosing alveolitis (15 and 14 patients respectively) but were uncommon in asbestosis (four and three patients). Pleural thickening or plaques were seen in 21 patients with asbestosis and in none with cryptogenic fibrosing alveolitis. CONCLUSION: Apart from showing pleural disease high resolution computed tomography showed that confluent (ground glass) opacities are common in cryptogenic fibrosing alveolitis and rare in asbestosis whereas thick, band like opacities are common in asbestosis and rare in cryptogenic fibrosing alveolitis.