RESEARCH IN ARTERIOSCLEROSIS—THE FIRST FIFTY YEARS
Authors: WILLIAM DOCK
Journal: Annals of Internal Medicine (1958)

Editorial1 September 1958RESEARCH IN ARTERIOSCLEROSIS—THE FIRST FIFTY YEARSWILLIAM DOCK, M.D.WILLIAM DOCK, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-3-699 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe year 1958 marks the fiftieth anniversary of the first successful experimental study of arteriosclerosis, the greatest killer of our century. The first experiment on tuberculosis had been completed forty years previously. Villemin's demonstration of tuberculosis in rabbits inoculated with human material made possible the isolation of the bacillus by Koch, and all subsequent studies of host sensitivity, diagnostic and therapeutic methods. It marked the beginning of the end of tuberculosis as an uncontrollable plague of city dwellers.When Ignatovski, of the Russian Imperial Military Medical Academy, reported in 1908 that rabbits fed milk and egg yolk developed severe arteriosclerosis,1...1 Ignatovski AI: On the influence of animal food on the tissues of the rabbit. Reports of the Imperial Military Medical Academy, Saint Petersburg 16: 154, 1908. Google Scholar2 Stuckey NW: On changes in the aorta of the rabbit due to feeding with different types of fat, Centralbl f. allg. Path u. path. Anat. 23: 910, 1912. Google Scholar3 AnichkovChalatov NS: On experimental cholesterol steatosis and its significance in the development of various pathologic processes, Centralbl. f. allg. Path u. path. Anat. 24: 1, 1913. Google Scholar4 Myasnikov AL: Influence of some factors on development of experimental cholesterol atherosclerosis, Circulation 17: 99, 1958. CrossrefMedlineGoogle Scholar5 Bailey CH: Atheroma and other lesions produced in rabbits by cholesterol feeding, J. Exper. Med. 23: 69, 1916. CrossrefMedlineGoogle Scholar6 Leary T: Atherosclerosis, the important form of arteriosclerosis, a metabolic disease, J. A. M. A. 105: 475, 1935. CrossrefGoogle Scholar7 MannMunozScrimshaw GVAN: The serum lipoprotein and cholesterol concentrations of Central and North Americans with different dietary habits, Am. J. Med. 19: 25, 1955. CrossrefMedlineGoogle Scholar8 HardingeStare MGFJ: Nutritional studies of vegetarians. Dietary and serum levels of cholesterol, J. Clin. Nutr. 2: 83, 1954. CrossrefMedlineGoogle Scholar9 Bronte-StewartAntonisEalesBrock BALJ: Effect of feeding different fats on serum cholesterol, Lancet 1: 521, 1956. CrossrefGoogle Scholar10 ToorKatchalskyAgmanAltaloref JAJD: Serum lipids and atherosclerosis among Yemenite immigrants in Israel, Lancet 1: 1270, 1957. CrossrefGoogle Scholar11 KeysKusakawaBronte-StewartLarsonKeys AABMMD: Lessons from serum cholesterol studies in Japan, Hawaii, and Los Angeles, Ann. Int. Med. 48: 83, 1958. LinkGoogle Scholar12 LiFreeman TWS: Experimental lipemia and hypercholesterolemia produced by protein depletion and by cholesterol-feeding in dogs, Am. J. Physiol. 145: 660, 1946. CrossrefMedlineGoogle Scholar13 StanleyCheng MMSH: Cholesterol exchange in the gastrointestinal tract in normal and abnormal subjects, Gastroenterology 30: 62, 1956. CrossrefMedlineGoogle Scholar14 Ahrens EH: Nutritional factors and serum lipid levels, Am. J. Med. 23: 928, 1957. CrossrefMedlineGoogle Scholar15 LambertMillerOlsenFrost GFJPRTDV: Hypercholesterolemia and atherosclerosis produced in rabbits by purified high fat rations devoid of cholesterol, Proc. Soc. Exper. Biol. and Med. 97: 544, 1958. CrossrefMedlineGoogle Scholar16 HellmanRosenfeldInsullAhrens LRSWEH: Regulation of plasma cholesterol levels by fecal sterol excretion, Circulation 16: 497, 1957. Google Scholar17 ScottThomas RFWA: Methods for comparing effects of various fats on fibrinolysis, Proc. Soc. Exper. Biol. and Med. 96: 24, 1957. CrossrefMedlineGoogle Scholar18 Snapper I: Chinese Lessons to Western Medicine, 1941, Interscience Publishers, Inc., New York, pages 30, 160. Google Scholar19 GroenTjongKammingaWillebrands JBKCEAF: The influence of nutrition, individuality and some other factors, including various forms of stress on the serum cholesterol, an experiment of nine months duration in 60 normal human volunteers, Voeding 13: 556, 1952. Google Scholar20 KinsellPartridgeBolingMargenMichaels LWJLSG: Dietary modification of serum cholesterol and phospholipid levels, J. Clin. Endocrinol. 12: 909, 1952. CrossrefMedlineGoogle Scholar21 AhrensBlankenhornTsaltas EHDHTT: Effect on human serum lipids of substituting plant for animal fat in diet, Proc. Soc. Exper. Biol. and Med. 86: 872, 1954. CrossrefMedlineGoogle Scholar22 PortmanHegstedStareBunoMurphySinisterra OWDMFJDRL: Effect of the level and type of dietary fat on the metabolism of cholesterol and beta lipoprotein in the Cebus monkey, J. Exper. Med. 104: 917, 1956. CrossrefGoogle Scholar23 OsborneAdlersburg RHD: Serum lipids in adult twins, Science 127: 1294, 1958. CrossrefMedlineGoogle Scholar24 FriedmanRosenmanCarroll MRHV: Changes in the serum cholesterol and blood clotting time in men subjected to cyclic variation of occupational stress, Circulation 17: 852, 1958. CrossrefMedlineGoogle Scholar25 Barr DP: Influence of sex and sex hormones on lipoproteins and the pathogenesis of atherosclerosis. Symposium on arteriosclerosis, 1957, Benno Schwabe and Co., Basel, p. 369. Google Scholar26 Lober PH: Pathogenesis of coronary sclerosis, A. M. A. Arch. Path. 55: 357, 1953. MedlineGoogle Scholar27 EnosHolmesBeyer WFRHJ: Coronary disease among United States soldiers killed in action in Korea, J. A. M. A. 152: 1090, 1953. CrossrefMedlineGoogle Scholar28 Bragdon JH: Spontaneous atherosclerosis in the rabbit, Circulation 5: 641, 1952. CrossrefMedlineGoogle Scholar29 YoungPilcher CMHL: Nutritional status survey, Croton Township, N. Y. II. Nutrient usage of families and individuals, J. Am. Diet. Assoc., Oct. 1950, 776-781. CrossrefMedlineGoogle Scholar30 EpprightSwanson ESPP: Distribution of calories in diets of Iowa school children, J. Am. Diet. Assoc. 31: 144, 1955. CrossrefMedlineGoogle Scholar31 DuguidRobertson JBWD: Mechanical factors in atherosclerosis, Lancet 1: 1205, 1957. CrossrefGoogle Scholar32 Morgan AD: The Pathogenesis of Coronary Occlusion, 1957, C. C Thomas, Springfield, Ill. Google Scholar33 RussekZohman HIBL: Relative significance of heredity, diet and occupational stress in coronary heart disease, Am. J. M. Sc. 235: 266, 1958. CrossrefMedlineGoogle Scholar34 YerushalmyHilleboe A: Fat in the diet and mortality from heart disease, New York State J. Med. 57: 2343, 1957. MedlineGoogle Scholar35 Yudkin J: Diet and coronary thrombosis—hypothesis and fact, Lancet 2: 1957, 155. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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