Idiosyncratic Acute Hepatitis Caused by Paracetamol in Two Patients with Melanoma Treated with High-Dose Interferon-α
Authors: Paolo Fabris, Maurizio Dalla Palma, Fausto de Lalla
Journal: Annals of Internal Medicine (2001)

Letters20 February 2001Idiosyncratic Acute Hepatitis Caused by Paracetamol in Two Patients with Melanoma Treated with High-Dose Interferon-αPaolo Fabris, MD, Maurizio Dalla Palma, MD, and Fausto de LallaPaolo Fabris, MDS. Bortolo Hospital; 36100 Vicenza, Italy (Fabris, Palma, de Lalla), Maurizio Dalla Palma, MDS. Bortolo Hospital; 36100 Vicenza, Italy (Fabris, Palma, de Lalla), and Fausto de LallaS. Bortolo Hospital; 36100 Vicenza, Italy (Fabris, Palma, de Lalla)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-4-200102200-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Acute hepatitis related to paracetamol dose is well documented, whereas idiosyncratic acute liver injury is almost unknown (1-4).A 47-year-old man and a 64-year-old woman with cutaneous melanoma began receiving adjuvant therapy with interferon-α2b (Intron-A, Schering-Plough, Italy), 20 MU/m2 daily five times per week during the first month, followed by 20 MU/m2 three times per week for 11 months. An influenza-like syndrome related to interferon-α was treated with paracetamol (500 to 1500 mg/d). After 2 months (for the male patient) and 3 weeks (for the female patient), liver aminotransferase levels progressively increased. Treatment was suspended and the ...References1. Johnson GK, Tolman KG. Chronic liver disease and acetaminophen. Ann Intern Med. 1977;87:302-4. [PMID: 0000900674] LinkGoogle Scholar2. Itoh S, Matsuo S, Shiomi , Ichinoe A. Cirrhosis following 12 years of treatment with acetaminophen [Abstract]. Hepatogastroenterology. 1983;30:58. Google Scholar3. Guerin C, Casez JP, Vital-Durand D, Levrat R. [Allergy to paracetamol. A case of hepatic and cutaneous involvement] [Letter]. Therapie. 1984;39:47-9. [PMID: 0006235621] MedlineGoogle Scholar4. Andrade RJ, Lucena MI, Garcia-Escano MD, Camargo R. Severe idiosyncratic acute hepatic injury caused by paracetamol [Letter]. J Hepatol. 1998;28:1078. [PMID: 0009672188] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Paolo Fabris, MD; Maurizio Dalla Palma, MD; Fausto de LallaAffiliations: S. Bortolo Hospital; 36100 Vicenza, Italy (Fabris, Palma, de Lalla) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLate-onset acetaminophen-induced allergic hepatitis with progression to chronicityFDA proposals to limit the hepatotoxicity of paracetamol (acetaminophen): are they reasonable?Mild hepatitis at recommended doses of acetaminophen in patients with evidence of constitutionally enhanced cytochrome P450 system activityDoes Therapeutic Use of Acetaminophen Cause Acute Liver Failure?Acute Liver Failure Due to Iron Overdose in an AdultTolerability of ParacetamolHepatic injury, liver monitoring and the beta-interferons for multiple sclerosisParacetamol-induced hepatotoxicity at recommended dosageParacetamol hepatotoxicity at therapeutic dosesParacetamol 20 February 2001Volume 134, Issue 4Page: 345KeywordsAlanine aminotransferaseAminotransferasesAntimitochondrial antibodiesBilirubinCytomegalovirus infectionHepatitisHepatitis ALiverMelanomaSerum glutamic oxaloacetic transaminase ePublished: 20 February 2001 Issue Published: 20 February 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...