tbuckley/cabot-search huggingface dataset:
Surveillance for Hepatocellular Carcinoma
Authors: Alain Braillon
Journal: Annals of Internal Medicine (2011)

Letters16 August 2011Surveillance for Hepatocellular CarcinomaAlain Braillon, PhDAlain Braillon, PhDFrom GRES, 80000 Amiens, France.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-4-201108160-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Davila and colleagues (1) showed that in a series of 13 002 patients with hepatitis C virus infection and concomitant hepatitis C virus infection and cirrhosis, screening for HCC is an enduring mistake. Indeed, routine surveillance only occurred in 12.0% of this population. This poor surveillance rate may only suggest that health care professionals do not trust the recommendations made by advocates for screening.Screening is a complex issue that necessitates a national program to ensure a minimum participation, quality controls, and evaluation of the results; these basic requirements are missing for screening for HCC. The program ...References1. Davila JA, Henderson L, Kramer JR, Kanwal F, Richardson PA, Duan Z, et al. Utilization of surveillance for hepatocellular carcinoma among hepatitis C virus-infected veterans in the United States. Ann Intern Med. 2011;154:85-93. [PMID: 21242365] LinkGoogle Scholar2. Braillon A. Screening for hepatocellular carcinoma: from lack of evidence to common sense [Letter]. Hepatology. 2010;52:1863-4. [PMID: 20658463] CrossrefMedlineGoogle Scholar3. El-Zayadi AR, Badran HM, Shawky S, Emara S, El-Bareedy A, Sobhi M. Effect of surveillance for hepatocellular carcinoma on tumor staging and treatment decisions in Egyptian patients. Hepatol Int. 2010;4:500-6. [PMID: 20827407] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From GRES, 80000 Amiens, France.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoUtilization of Surveillance for Hepatocellular Carcinoma Among Hepatitis C Virus–Infected Veterans in the United States Jessica A. Davila , Louise Henderson , Jennifer R. Kramer , Fasiha Kanwal , Peter A. Richardson , Zhigang Duan , and Hashem B. El-Serag Surveillance for Hepatocellular Carcinoma Steven H. Smoger Surveillance for Hepatocellular Carcinoma Jessica A. Davila and Hashem B. El-Serag Surveillance for Hepatocellular Carcinoma Michael J. Kelley Metrics Cited byHepatocellular carcinomaHepatocellular Carcinoma: Still in Search of Evidence-Based Care 16 August 2011Volume 155, Issue 4Page: 274-275KeywordsHepatitis AHepatitis C virusObservational studiesPatient advocacyPeer reviewProstate cancerQuality improvementUltrasound imaging ePublished: 16 August 2011 Issue Published: 16 August 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The HLA-A*0201-Restricted H-Y Antigen Contains a Posttranslationally Modified Cysteine That Significantly Affects T Cell Recognition
Authors: Leslie Meadows, Wei Wang, Joke M.M den Haan, Els Blokland, Carla Reinhardus, Jan W Drijfhout, Jeffrey Shabanowitz, Richard Pierce, Alexander I Agulnik, Colin E Bishop, Donald F Hunt, Els Goulmy, Victor H Engelhard
Journal: Immunity (1997)
A Novel Chimeric Adenoassociated Virus 2/Human Bocavirus 1 Parvovirus Vector Efficiently Transduces Human Airway Epithelia
Authors: Ziying Yan, Nicholas W Keiser, Yi Song, Xuefeng Deng, Fang Cheng, Jianming Qiu, John F Engelhardt
Journal: Molecular Therapy (2013)

Human bocavirus virus-1 (HBoV1), a newly discovered autonomous parvovirus with a 5,500 nt genome, efficiently infects human-polarized airway epithelia (HAE) from the apical membrane. We hypothesized that the larger genome and high airway tropism of HBoV1 would be ideal for creating a viral vector for lung gene therapy. To this end, we successfully generated recombinant HBoV1 (rHBoV1) from an open reading frames-disrupted rHBoV1 genome that efficiently transduces HAE from the apical surface. We next evaluated whether HBoV1 capsids could package oversized rAAV2 genomes. These studies created a rAAV2/HBoV1 chimeric virus (5.5 kb genome) capable of apically transducing HAE at 5.6- and 70-fold greater efficiency than rAAV1 or rAAV2 (4.7-kb genomes), respectively. Molecular studies demonstrated that viral uptake from the apical surface was significantly greater for rAAV2/HBoV1 than for rAAV2 or rAAV1, and that polarization of airway epithelial cells was required for HBoV1 capsid-mediated gene transfer. Furthermore, rAAV2/HBoV1-CFTR virus containing the full-length cystic fibrosis transmembrane conductance regulator (CFTR) gene coding sequence and the strong CBA promoter efficiently corrected CFTR-dependent chloride transport in cystic fibrosis (CF) HAE. In summary, using the combined advantages of AAV and HBoV1, we have developed a novel and promising viral vector for CF lung gene therapy and also potentially HBoV1 vaccine development.
PSYCHOPATHOLOGY OF STUTTERING
Authors: J. LOUISE DESPERT
Journal: American Journal of Psychiatry (1943)

The speech structures are described from the point of view of their relation to the upper respiratory and upper digestive tract. Their utilization in the finely co-ordinated function of speech is also described. The stuttering disorder is defined, and the predominance of tonic or clonic features is emphasized. Associated movements, respiratory and vasomotor disturbances are included. The theories of the etiology of stuttering are reviewed. The findings of a detailed clinical study of 15 cases of stuttering in children are summarized, and the psychodynamic factors analyzed. One typical case is presented from the point of view of anamnestic data, etiology, treatment and course. The importance of maternal neurotic attitudes in the early eating-speaking situation where the transfer of functions of oral structures attains is brought out. Other developmental phases coincident with the period of this early eating-speaking situation are studied from the point of view of contributing factors.
Newborn babies will be tested for four more disorders, committee decides
Authors: N. Hawkes
Journal: BMJ (2014)

Four new genetic disorders will be added to those already screened for in newborn babies, the UK National Screening Committee has announced.

The decision followed a 12 month pilot study at six centres in England, which found 12 confirmed cases of these four rare conditions in just under 440 000 births, using blood samples taken from the “heel prick” blood test given to all newborns at 5 to 8 days of age.

The test is already used to screen for phenylketonuria, hypothyroidism, sickle cell disease, cystic fibrosis, and medium chain acyl-CoA dehydrogenase deficiency. To these five conditions four more will now be added: homocystinuria, maple syrup …
Genomic gains and losses influence expression levels of genes located within the affected regions: a study on acute myeloid leukemias with trisomy 8, 11, or 13, monosomy 7, or deletion 5q
Authors: C Schoch, A Kohlmann, M Dugas, W Kern, W Hiddemann, S Schnittger, T Haferlach
Journal: Leukemia (2005)
Outcome prediction for patients with cirrhosis of the liver in a medical ICU: A comparison of the APACHE scores and liver-specific scoringsystems
Authors: C. A. Zauner, R. C. Apsner, A. Kranz, L. Kramer, C. Madl, B. Schneider, B. Schneeweiss, K. Ratheiser, F. Stockenhuber, K. Lenz
Journal: Intensive Care Medicine (1996)
MALE GENDER AND STRUCTURAL RIGHT VENTRICULAR ABNORMALITY BY IMAGING INDEPENDENTLY PREDICT SYMPTOMS IN PATIENTS WITH ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY
Authors: Pyotr G. Platonov, Kristina Haugaa, Henning Bundgaard, Thomas Gilljam, Henrik K. Jensen, Jim Hansen, Rasmus Borgquist, Ole Eschen, Jere Jarvenpaa, Anders G. Holst, Thor Edvardsen, Jesper H. Svendsen
Journal: Journal of the American College of Cardiology (2014)
Combined Treatment With Arsenic Trioxide and All-Trans-Retinoic Acid in Patients With Relapsed Acute Promyelocytic Leukemia
Authors: Emmanuel Raffoux, Philippe Rousselot, Joël Poupon, Marie-Thérèse Daniel, Bruno Cassinat, Richard Delarue, Anne-Laure Taksin, Delphine Réa, Agnès Buzyn, Annick Tibi, Geneviève Lebbé, Patricia Cimerman, Christine Chomienne, Jean-Paul Fermand, Hugues de Thé, Laurent Degos, Olivier Hermine, Hervé Dombret
Journal: Journal of Clinical Oncology (2003)

Arsenic trioxide (ATO) is capable of inducing a high hematologic response rate in patients with relapsed acute promyelocytic leukemia (APL). Preclinical observations have indicated that all-trans-retinoic acid (ATRA) may strongly enhance the response to ATO.Between 1998 and 2001, we conducted a randomized study of ATO alone versus ATO plus ATRA in 20 patients with relapsed APL, all previously treated with ATRA-containing chemotherapy. The primary objective was to demonstrate a significant reduction in the time necessary to obtain a complete remission (CR) in the ATO/ATRA group compared with the ATO group. Secondary objectives were safety and molecular response.The CR rate after one ATO with or without ATRA induction cycle was 80%. Clinical and pharmacokinetic observations indicated that the main mechanism of action of ATO in vivo was the induction of APL cell differentiation. Hematologic and molecular response, time necessary to reach CR, and outcome were comparable in both treatment groups. Of 16 CR patients, three patients who reached a molecular remission after one induction cycle had all received chemotherapy for a treatment-induced hyperleukocytosis. Three additional patients who received further additional ATO with or without ATRA cycles converted later to molecular negativity.ATRA did not seem to significantly improve the response to ATO in patients relapsing from APL. Other potential combinations, including ATO plus chemotherapy, have to be tested.
A 4‐week comparison of salmeterol and terbutaline in adult asthma*
Authors: B. A. Hermansson, R. J. Jenkins
Journal: Allergy (1995)

This was a 4‐week, open‐label, parallel‐group study designed to compare the efficacy and safety of the long‐acting inhaled bronchodilator, salmeterol, with the established inhaled bronchodilator, terbutaline, in the treatment of patients with mild to moderate asthma. A total of 243 adult patients was randomized to receive treatment with either salmeterol 50 μg bd via a Diskhaler TM (Glaxo) inhaler ( n =121) or terbutaline 500 μg qds via a reservoir powder inhaler device ( n =122). Apart from all bronchodilator treatment which was withdrawn at the start of the run‐in period and replaced by inhaled salbutamol to be used as required for symptom relief, all concurrent medications were kept constant throughout the study. Salmeterol produced a significantly greater increase in mean morning peak expiratory flow (PEF) than terbutaline (difference in adjusted means after treatment=28 l/min; 95% CI=19–37 l/min; P &lt;0.001). Likewise, the increase in mean evening PEF was significantly greater following treatment with salmeterol than with terbutaline (difference in adjusted means=9 l/min; 95% CI=0–17 l/min; P =0.045). Salmeterol was associated with a significant reduction in diurnal variation in PEF by comparison with terbutaline (difference in adjusted means=−18 l/min; 95% CI=−24, −12 l/min; P &lt;0.001). Significant improvements with salmeterol by comparison with terbutaline were also observed in daytime and night‐time asthma scores, percentage of symptom‐free days and nights, use of additional inhaled bronchodilator, and percentage of days and nights when no additional inhaled bronchodilator was needed. The greater overall improvement in the control of asthma and its symptoms after treatment with salmeterol was further evident from the lower incidence of asthma‐related adverse events in patients taking salmeterol compared with those taking terbutaline (2% and 15%, respectively). While both treatments were well tolerated, more patients withdrew from the terbutaline group than from the salmeterol group (12 and 3 patients, respectively) and terbutaline was associated with a higher incidence of drug‐related adverse events (26% and 9% in the terbutaline‐ and salmeterol‐treated groups, respectively). This study demonstrated that salmeterol 50 mUg bd via a Diskhaler was significantly more effective and associated with fewer adverse events than terbutaline 500 μg qds via a reservoir powder inhaler device.
Identification of Biomarkers in Nasal Lavage Fluid (NLF) Associated with Early and Late Phase Symptoms Induced by Intranasal Challenge with Ragweed Extract (RWE)
Authors: H. Qi, D. Redding, A. Kurosky, B. Singh, I. Boldogh, K. Soman, J.A. Grant, V. Cardenas, S. Sur
Journal: Journal of Allergy and Clinical Immunology (2009)
Prevalence and Patterns of Bone Metastases Detected with Positron Emission Tomography Using F-18 FDG
Authors: YUJI NAKAMOTO, MEDHAT OSMAN, RICHARD L. WAHL
Journal: Clinical Nuclear Medicine (2003)

Purpose The aim of this retrospective study was to report the prevalence and imaging characteristics of bone metastases detected with F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) and, when possible, compare these findings with the performance of bone scans in the same patients. Methods The reports of 403 patients with histologically proved malignant disease who underwent a PET scan for initial or post-therapeutic staging were reviewed for the presence of possible bone metastases. Based on the final diagnosis confirmed by histopathologic analysis or clinical follow-up, the PET findings of patients with positive bone metastases were evaluated in terms of location, intensity, and patterns. When the PET scan was positive, the PET results were compared with the findings of available bone scans. Results PET studies suggested the presence of bone metastases in 38 patients (9%). No follow-up data were available for 9 patients, and the remaining 29 were evaluated further. Of these patients, 6 had false-positive findings, whereas bone metastatic involvement was clinically confirmed in 23 patients. The primary malignant findings included lung cancer (n = 9), esophageal cancer (n = 3), lymphoma (n = 2), melanoma (n = 2), thyroid cancer (n = 2), breast cancer (n = 1), colon cancer (n = 1), prostate cancer (n = 1), testicular cancer (n = 1), and nasopharyngeal cancer (n = 1). On PET, 5 patients had a solitary metastatic focus (22%), and the remaining 18 patients had multiple lesions (78%). The vertebrae were the most frequently involved bones (74%), followed by pelvic bones (70%), ribs (65%), upper extremities including the scapula (48%), sternum (43%), and lower extremities (43%). The patterns of abnormal uptake were classified into three groups: focal (15 patients, 65%), diffuse (2 patients, 9%), and a mixed pattern (6 patients, 26%). Most of the lesions showed intense abnormal uptake (18 patients, 78%); 5 patients had both intense and moderate FDG uptake. Thirteen of the 23 patients with confirmed bone metastases also had a bone scan, which revealed positive bone disease in all of these patients. However, PET consistently revealed more metastatic foci than did the bone scan on a lesion basis. Conclusions The most frequent pattern of detectable bone metastases with FDG-PET imaging was multiple foci of intense uptake. PET revealed more lesions than did bone scanning, independent of the type of cancer or location of bone involvement, in patients who were accurately diagnosed by FDG-PET imaging.
Transbronchial Lung Biopsy in the Compromised Host-Reply
Authors: Neil T. Feldman
Journal: JAMA (1978)

Dr Chapman's point is well taken. However, in addition to inconvenience, one has to explain in detail to the patient the hazards of the procedure, emphasize its importance, and then risk magnifying the patient's anxiety by cancelling, at a very inopportune moment, a procedure that the patient now considers so important to his treatment. In addition, it is unlikely that Dr Chapman's approach would reduce by half the risk of transfusion, as most of these patients have received multiple transfusions of RBCs and platelets prior to the development of lung disease and continue to require platelet support for some time after the procedure. We have been tempted to use Dr Chapman's approach because of the one-day delay in diagnosis, but we have chosen a transfusion test the day prior to biopsy for these reasons.
Mentally disordered offenders.
Authors: O W Fitzgerald
Journal: BMJ (1979)

prostacyclin production if the non-precursor fats are peroxidised.4Certainly, to choose a margarine with a high content of C18:2co6 in the cis form needs more information than is provided on the label, and none exists with a high content of eicosapentaenoic acid, which may be preferable.From the point of view of a healthy cardio- vascular system, it could be that we should be debating a fat intake based on fish rather than meat, instead of butter versus margarine.
X-Linked, Pyridoxine-Responsive Sideroblastic Anemia
Authors: John W. Harris
Journal: New England Journal of Medicine (1994)

In a normal adult, 2 × 1011 worn-out red cells die every day. In replacing them with an equal number of fresh erythrocytes, the bone marrow synthesizes 4 × 1014 molecules of hemoglobin per second. These hemoglobin molecules consist of two equal partners: heme and globin. To make heme, an atom of iron is inserted from the young erythroblast into the center of an intensely colored ring of protoporphyrin IX; simultaneously, the developing red cell synthesizes two kinds of globin chains, α and β, which are joined to the heme molecule. The developing red cells coordinate these components of hemoglobin . . .
Degradation of human cartilage by synovial fluid but not cytokines in vitro.
Authors: A P Hollander, R M Atkins, D M Eastwood, P A Dieppe, C J Elson
Journal: Annals of the Rheumatic Diseases (1991)

Synovial fluids from patients with rheumatoid arthritis and from patients with osteoarthritis degraded the matrix of living, but not killed, normal human cartilage as judged by loss of glycosaminoglycans. Normal human serum did not degrade living cartilage and neither, unexpectedly, did recombinant human cytokines.
Comment on: Harrison et al. <b>β</b>-Cell Function Preservation After 3.5 Years of Intensive Diabetes Therapy. Diabetes Care 2012;35:1406–1412
Authors: Toru Aizawa, Keishi Yamauchi
Journal: Diabetes Care (2012)

Harrison et al. (1) analyzed pancreatic β-cell function in drug-naive patients with type 2 diabetes before and 42 months after treatment with insulin plus metformin or a combination of metformin, glyburide, and pioglitazone. The pretreatment evaluation was not exactly “before” the treatment. It was carried out after 3 months of the run-in period with insulin plus metformin therapy for all participants. The study is well designed, the analysis is appropriate, and the data are straightforward except for two potential drawbacks: absence of a wash-out period prior to the final meal …
European Commission draws up measures on seeking health care abroad
Authors: Rory Watson
Journal: BMJ (2006)

The European Commission is facing the challenge of drawing up a package of measures to ensure that different national health systems are compatible with European Union rules.

Last week it launched wide ranging consultations that will run until the end of the year. After assessing the input it will table concrete proposals during the first half of next year. These would then have to be approved by EU governments and the European parliament.

The commission stresses that the aim is not to harmonise national health systems; the benefits and services they provide remain national responsibilities. Instead the aim is to guarantee legal certainty …
Dementia in the elderly: diagnosis and assessment.
Authors: T Arie
Journal: BMJ (1973)

In operation the pump is connected to the patient's bladder (B), to a bag under the bed (A), and to a bottle of normal saline over the bed (C) (fig. 3). In the piston's normal or resting position the urine from the bladder will run directly into the bag under the bed along the groove in the piston. In the event of the cath eter becoming blocked the pump handle is rotated clockwise through 90 degrees. This links up the groove in the piston with the port in the cylinder connected to the bottle over the bed. The piston is then withdrawn to its limit, thus filling the cylinder with saline. When the handle is rotated through a further 90 degrees the contents of the cylinder are connected to the bladder into which they are emptied when the piston is pushed into the cylinder. In this position only one movement is allowed by the location of the peg in the piston, and this is upwards, with drawing fluid from the bladder. A further rotation of 90 degrees brings the groove in the piston next to port A, into which the contents of the cylinder can then be pumped. The final rotation of the handle through 90 degrees brings the piston back to its starting point, the groove joining port B to port A. No internal dimension within the pump is less than t in (6 mm) in diameter and this appears to be adequate to prevent blockage by blood clots. The pump has been used successfully on patients and the nursing staff find the sequence of operations easy to follow, as the pump allows only one movement from a given position. The pump can break up quite large clots and eject them into the drainage bag. Because any fluid used to wash out the bladder is metered into the drainage bag urine output is easy to calculate. The piston of the prototype pump was made from poly tetrafluoroethylene and the cylinder was made from Perspex. The device has been sterilized in glutaraldehyde (Cidex) as the present materials do not withstand autoclaving. The possibility of making the pump out of stainless steel in a form which will allow it to be taken apart for cleaning and autoclaving is being investigated.
M08-01: Taxane-platinum pharmacogenomic predictors of outcome in Japan-USA common arm studies in advanced non-small cell lung cancer (NSCLC): a model for testing population-related pharmacogenomics
Authors: D.R. Gandara, T Kawaguchi, J Crowley, J Moon, K Furuse, M Kawahara, S Teramukai, Y Ohe, Y.Y. Nishiwaki, Y Ariyoshi, S Williamson, O Gautschi, H.J. Lenz, P.C. Mack, H.L. McLeod, M Fukuoka, N Saijo
Journal: Journal of Thoracic Oncology (2007)
MOLLUSCUM CONTAGIOSUM OF THE NEWBORN
Authors: MICKEY J. MANDEL, RICHARD J. LEWIS
Journal: British Journal of Dermatology (1971)

Journal Article MOLLUSCUM CONTAGIOSUM OF THE NEWBORN Get access MICKEY J. MANDEL, MICKEY J. MANDEL Department of Dermatology, University of Colorado Medical Centre, 4200 East Ninth Avenue, Denver, Colorado 80220 Search for other works by this author on: Oxford Academic Google Scholar RICHARD J. LEWIS RICHARD J. LEWIS Department of Dermatology, University of Colorado Medical Centre, 4200 East Ninth Avenue, Denver, Colorado 80220 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 84, Issue 4, 1 April 1971, Pages 370–372, https://doi.org/10.1111/j.1365-2133.1971.tb14234.x Published: 01 April 1971 Article history Accepted: 14 December 1970 Published: 01 April 1971
914 THE ROLE OF HEV TESTING IN DRUG INDUCED LIVER INJURY
Authors: H.J. Fellows, W. Stableforth, M. Joseph, P. Thurairajah, U. Warshow, S. Hazeldine, R. Remnarace, S. Ijaz, S.H. Hussaini, R.P. Bendall, H.R. Dalton
Journal: Journal of Hepatology (2008)