tbuckley/cabot-search huggingface dataset:
The Season's End
Authors: Samuel C. Durso
Journal: Annals of Internal Medicine (1998)

On Being a Doctor15 October 1998The Season's EndSamuel C. Durso, MDSamuel C. Durso, MDJohns Hopkins University School of Medicine; Baltimore, MD 21224Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-8-199810150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Sometimes Ezra would kid about the future. “What'll happen when I'm gone?” he would ask with mock seriousness. “The fish and ducks will rest a lot easier.”We would both laugh, exchanging glances like friends playing poker, looking for a hint of change in the other's expression.It had been a year since I met Ezra. I had become his student of sorts, following him all over the tidal marshes surrounding our hometown, Port Arthur, Texas. I was his doctor, too, and he couldn't help asking me often in his casual, by-the-way manner, “How am I doing, Doc?”Using my ... Author, Article, and Disclosure InformationAuthors: Samuel C. Durso, MDAffiliations: Johns Hopkins University School of Medicine; Baltimore, MD 21224Corresponding Author: Samuel C. Durso, MD, 8800 Walther Boulevard, Parkville, MD 21234. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1998Volume 129, Issue 8Page: 658-660KeywordsCoffeeFirearm injuriesForecastingHeartMarshesMosquitoesMouthOxygenRiversSalts ePublished: 15 August 2000 Issue Published: 15 October 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Psychogenic Factors In Acne
Authors: E. LIPMAN COHEN.
Journal: British Journal of Dermatology (1945)

Journal Article Psychogenic Factors In Acne Get access E. LIPMAN COHEN. E. LIPMAN COHEN. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 57, Issue 3-4, 1 March 1945, Pages 48–57, https://doi.org/10.1111/j.1365-2133.1945.tb11198.x Published: 01 March 1945
Letter: Oxytocin and neonatal jaundice.
Authors: I Chalmers, H Campbell, A C Turnbull
Journal: BMJ (1976)

Bran content of wholemeal bread SIR,-In a recent reply to a query (24 January, p 203) it was erroneously stated that 900 g of wholemeal bread was equivalent to 150- 200 g of bran.The correct value is of the order of 90 g bran (at 14%/' moisture content), assuming 40% moisture content in the bread and making due allowance for the yeast, salt, and fat used in bread-making.The calculation is based on a bran content of wheat of 15%.
Establishment of Time-Action Profiles for Regular and NPH Insulin Using Pharmacodynamic Modeling
Authors: James R Woodworth, Daniel C Howey, Ronald R Bowsher
Journal: Diabetes Care (1994)

OBJECTIVE To provide distinct definitions and quantify the establishment of onset, peak, and duration of action for insulins. RESEARCH DESIGN AND METHODS We administered single subcutaneous doses of 10 U regular insulin to 10 volunteer subjects and 25 U NPH insulin to 6 healthy male volunteer subjects on separate occasions. Each dose was given after an overnight fast during a glucose clamp to maintain an euglycemic state. We measured serum insulin concentrations and glucose infusion rates (GIR) from frequent blood sampling after each treatment. Serum insulin concentrations were related to GIR values at each collection time and a counter-clockwise hysteresis resulted. An effect compartment model was used to simultaneously describe the pharmacokinetics and pharmacodynamics of each insulin and to resolve the hysteresis. RESULTS From the resulting relationship, GIR could then be predicted, with onset and duration of action reflecting the time when effect compartment concentrations initially exceeded then declined below a 10% maximum possible effect (Emax) level. Ninety-five percent confidence intervals were constructed allowing a predictive range of values. For regular insulin, a mean onset of 0.75 h, peak of 2 h, and duration of 6 h was estimated. Mean values were also produced with NPH, with an onset of 3 h, peak of 6–7 h, and a duration of 13 h estimated. CONCLUSIONS This method estimates the onset, peak, and duration of insulin action. Although these estimates were from single doses, we believe they can provide good estimations of insulin activity.
Growth control of human biliary epithelial cells by interleukin 6, hepatocyte growth factor, transforming growth factor β1, and activin a: Comparison of a cholangiocarcinoma cell line with primary cultures of non-neoplastic biliary epithelial cells
Authors: Shigeki Yokomuro, Hirokazu Tsuji, John G. Lunz, Toshiki Sakamoto, Tsukasa Ezure, Noriko Murase, Anthony J. Demetris
Journal: Hepatology (2000)

A well characterized human cholangiocarcinoma (CC) cell line, SG231, was compared with primary cultures of normal human biliary epithelial cells (BECs) for alterations in interleukin 6 (IL-6) and hepatocyte growth factor (HGF)-mediated stimulation and transforming growth factor beta1 (TGF-beta1) and activin A-mediated inhibition of growth. Results were compared with immunolabeling of the original tumor and after injection of SG231 into the liver of BALB/cByJ-scid mice. In vitro, both BECs and CCs expressed met, gp80, and gp130 messenger RNA (mRNA) and protein, but the levels of expression were higher in the CCs than in the BECs. In both the CCs and BECs, exogenous HGF or IL-6 induced phosphorylation of met or gp130, respectively, and a concentration-dependent increase in DNA synthesis. However, the CCs but not BECs, continued to grow in basal serum-free medium (SFM) and spontaneously produced both IL-6 and HGF under these conditions, which resulted in auto-phosphorylation of gp130 and met, respectively; and neutralizing anti-HGF or anti-IL-6 alone inhibited CC growth, indicative of autocrine growth control circuits. Conversely, activin A inhibits the growth of both BECs and CCs, but does not significantly increase apoptosis. Activin-A-induced growth inhibition of both CCs and BECs can be reversed by 100 ng/mL exogenous IL-6, but not by 10 to 100 ng/mL HGF. TGF-beta1 inhibited the growth of BECs but had no mitoinhibitory or proapoptotic effects on CCs. Immunolabeling of the original tumor and after inoculation into scid mice showed positive staining for met, gp130, gp80, and IL-6. This study contributes to a further understanding of BEC growth control and derangements that can occur during cholangiocarcinogenesis.
Genesal and Practical Significance of Ammonia in Liver Disease. Lilly Lecture.
Authors: J. Stahl
Journal: Annals of Internal Medicine (1962)

s1 April 1962Genesal and Practical Significance of Ammonia in Liver Disease. Lilly Lecture.J. StahlJ. StahlSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-681_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInvestigation of ammonia metabolism in liver disease has developed in a large field, from which some significant basic and practical principles already have emerged. Methods of blood ammonia measurements have to be appraised very critically. In uncomplicated cirrhosis, the ammonia tolerance test with simultaneous measurements of arterial and venous ammonia provides a distinction between hepatic and extrahepatic ammonia metabolism; blood ammonia at different venous levels varies in relation to circulatory conditions.Electroencephalographic changes have been related to different blood ammonia patterns obtained by ammonia loading in cirrhosis. Ammonium salts can induce coma or neurologic symptoms in cirrhotics under special predisposing... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. StahlAffiliations: Strasbourg France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 681-681KeywordsAmmoniaBloodCirrhosisComaElectroencephalographyHematologic testsLiver diseasesSalts ePublished: 1 December 2008 Issue Published: 1 April 1962 PDF downloadLoading ...
Communicating Medical News — Pitfalls of Health Care Journalism
Authors: Susan Dentzer
Journal: New England Journal of Medicine (2008)

Whether they realize it or not, journalists reporting on health care developments deliver public health messages that can influence the behavior of clinicians and patients. Often these messages are delivered effectively by seasoned reporters who perform thoughtfully even in the face of breaking news and tight deadlines. But all too frequently, what is conveyed about health by many other journalists is wrong or misleading. Some distortion is attributable to ignorance or an inability to interpret and convey the nuanced results of clinical studies. And some is due to uncertainty about journalists' proper role: Is our job to describe the bigger . . .
GMC revalidation scheme passes first hurdle
Authors: Z. Kmietowicz
Journal: BMJ (2001)

Inspectors have declared the proposed scheme to revalidate all UK doctors a success after a pilot study showed the “folder and appraisal” method to be relatively straightforward both to assemble and to assess.

A team of experts assigned by the General Medical Council to test the feasibility of revalidation collected over 250 folders from volunteer doctors earlier this year. Out of these, 80 folders were selected for inspection by revalidation panels made up of doctors and lay people. The 80 folders were chosen in equal numbers from four groups: general practitioners, surgeons and anaesthetists, hospital physicians, and others (doctors from …
Manipulating the Type 1 Diabetes Disease Process, Man Versus Mouse
Authors: Jerry P. Palmer
Journal: Diabetes Care (2002)

In their article in this month’s issue of Diabetes Care , Hummell et al. (1) tested the hypothesis that gluten is a driving antigen for type 1 diabetes-associated islet autoimmunity. They convincingly demonstrated that elimination of dietary gluten for 12 months in humans positive for at least two type 1 diabetes-associated autoantibodies does not consistently alter the titers of these antibodies. The study is well done and carefully analyzed. Their conclusion that gluten does not drive islet autoantibody production in type 1 diabetes, as it does in celiac disease, seems very appropriate. Yet, because the β-cell lesion of type 1 diabetes is T-cell and not antibody mediated, and because antibody and T-cell responses to the same antigen can be markedly different or even reciprocally related, they cannot conclude that the underlying type 1 diabetes disease process in humans is not altered by elimination of dietary gluten for 12 months.

Nonetheless, I feel that studies such as this are extremely important because they provide information that allows us to compare specific aspects of the type 1 diabetes disease process in man versus mouse. A tremendous amount has …
Biomedical Research Policy — A Re-Evaluation
Authors: Robert H. Ebert
Journal: New England Journal of Medicine (1973)

Abstract Recent cuts in federal spending for biomedical research and training programs express the attitude of the Nixon administration, but are also quite consistent with past policies, which universities and medical centers generally have influenced little. Major policy directions, instead, have been set by Councils of the National Institutes of Health, by voluntary health organizations, and by and large, private foundations. These policies include categorical approach to problems of disease, and temporary funding. Medical center and university faculty have contributed by placing university loyalty second to that accorded the NIH. Suggested solutions include consolidation of the categorical NIH Institutes into one National Institute of Health; redefinition of training programs to encompass obligations to train teachers as well as researchers; a clean separation between federal funding for medical education and medical research; and changes that focus faculty thinking along university lines rather than those of special interest groups. (N Engl J Med 289:348–351, 1973)
Infectious hepatitis in Leicester 1963-6.
Authors: C. Burns
Journal: BMJ (1967)

During the latter part of 1962 the Leicester City Health Department became aware of an increasing incidence of infec tious hepatitis among schoolchildren, and on 1 July 1963 the disease was made notifiable in Leicester by an order under Section 147 of the Public Health Act, 1936. This order was to run initially for a three-year period, ending on 30 June 1966, but has been extended for a further three years. A marginal punch card was devised in conjunction with Kalamazoo Limited to record details of cases, and full informa tion regarding each notified case was obtained at special home visits carried out by health visitors or clinic nurses. During the three-year period 961 cases were notified, and this paper presents an analysis of the epidemiological features of the out
Terms, Concepts, and Objectives
Authors: Zenonas Danilevicius
Journal: JAMA (1976)

If the physician who lived and worked only 50 years ago could be recalled to the practice of medicine today, he would be bewildered by the jargon used by his colleagues. He would be dumbfounded by terms like "primary care," "community medicine," "health-care delivery," "health-care centers," "family medicine," "total care," and "regional health centers." Are these terms necessary? Some should not be used at all. For example, I know of obstetrical delivery, but I cannot imagine what "healthcare delivery" is. I never understood what a "walk-in clinic" means. Is it a clinic where the patient walks in when he likes or is it a clinic to which the doctor walks instead of arriving by other means? Other terms, though legitimate, are imprecise. "Community medicine," "healthcare systems," "ambulatory care," and "primary medical care" do not convey the same meaning to all physicians. "Primary care" should mean medical aid at a doctor's
28: Stories of AIDS in Africa
Authors: Preeti N. Malani
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chemical Diagnosis of Sympath-adrenal Tumors.
Authors: A. Sjoerdsma
Journal: Annals of Internal Medicine (1963)

s1 April 1963Chemical Diagnosis of Sympath-adrenal Tumors.A. Sjoerdsma, M.D., Ph.D.A. Sjoerdsma, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-722_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is well known that pheochromocytomas secrete A excess amounts of the catecholamines, norepinephrine and epinephrine. While diagnosis can usually be made by proper interpretation of the clinical picture and results of pharmacologic tests, chemical assay of the urine for catecholamines and their metabolites affords the most definitive diagnostic evidence and may also offer information on localization of the tumor. Recently, it has been shown that other sympatho-adrenal tumors,i.e., neuroblastoma and ganglioneuroma also may secrete catecholamine intermediates and metabolites. Studies in patients with these various conditions will be used to illustrate the biochemistry of the catecholamines; the diagnostic aspects... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: A. Sjoerdsma, M.D., Ph.D.Affiliations: Bethesda, Md. (BS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 722-722KeywordsBiochemistryCatecholaminesEpinephrineMetabolitesNeuroblastomaNorepinephrinePheochromocytomaUrine ePublished: 1 December 2008 Issue Published: 1 April 1963 PDF downloadLoading ...
Bending the Cost Curve
Authors: Stephen M. Shortell
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Letter: Coeliac disease and diffuse pulmonary disease.
Authors: J Cummiskey, P Keelan, D G Weir
Journal: BMJ (1976)

graphy).Indeed it seems likely that computer tomography will increasingly permit selective percutaneous biopsy of solid abdominal organs. 9Laparotomy is not the only way of making a certain pancreatic diagnosis, and is not always the best.
Transposition of the Great Vessels with Atrial Septal Defect
Authors: SUSAN C. LENKEI, H. J. C. SWAN, JAMES W. DUSHANE
Journal: Circulation (1959)

In complete transposition of the great vessels, survival is possible only when a route of access exists by means of which venous blood may enter the lungs. This report concerns 2 patients in relatively good health in whom a high degree of mixing of venous and arterial blood occurred through an atrial septal defect. The diagnosis was established in both patients by cardiac catheterization.
Does Estrogen Receptor–Negative/Progesterone Receptor–Positive Breast Carcinoma Exist?
Authors: Leen De Maeyer, Erik Van Limbergen, Katelijne De Nys, Philippe Moerman, Nathalie Pochet, Wouter Hendrickx, Hans Wildiers, Robert Paridaens, Ann Smeets, Marie-Rose Christiaens, Ignace Vergote, Karin Leunen, Frederic Amant, Patrick Neven
Journal: Journal of Clinical Oncology (2008)
Perforation of a Gastric Ulcer Following Intensive Radiation Therapy
Authors: William Feiring, Morris L. Jampol
Journal: New England Journal of Medicine (1950)

RADIATION injury of the normal gastrointestinal tract depends upon individual susceptibility as well as the dose to which the subject is exposed. Reports of lesions of the lower intestine after intensive pelvic x-ray and radium treatments are not uncommon,1 since such therapeutic methods are frequently employed in the management of tumors of the female generative organs. Because x-ray beams are rarely concentrated on the epigastric area, serious ulceration of the stomach is seldom encountered. But Bowers and Brick2 and Hamilton3 have called attention to the potential intractability of the radiation-induced ulcer of the stomach when that organ is within the . . .
POSITION OF THE WOMAN DURING DELIVERY.
Authors: WILLIAM D. PORTER
Journal: JAMA (1901)

The literature of this subject is practically confined to two questions: 1. What effect has posture on the mechanics of labor? 2. How does posture affect the pelvic diameters? It is not the purpose of this paper to discuss either of these questions; but rather to consider posture with reference to its bearing on sepsis, and to determine, if possible, what position is most conducive to an aseptic technique. The plan of delivering the woman as she lies in bed—the amniotic fluid, the child, the blood, the placenta and often fecal matter being received by the bed or its protections—has had from antiquity to the present, the sanction of universal custom. With such conditions an aseptic technique is incompatible. In the homes of those who are able to command the comforts and some of the luxuries of life, these unfavorable conditions can be greatly modified. Given a clean patient in
Points from Letters: Antibiotic Vaginitis
Authors: G. M. Sandes
Journal: BMJ (1966)

But whatever the attitude of our negotia- tors there can be no doubt that the proposal for "merit" awards to certain selected persons for doing no extra work and carrying no extra responsibility, but merely, as in much of the specialist field today, for orientating activities to catch the eye of those in authority more than for the benefit of the patient, will seriously split the profession once more.We shall have a hierarchy with its hangers-on in one camp and those without hope of getting on the band-wagon in the other.This is about the worst thing that could happen to general practice.Dr. John D. Avison (5 March, p. 608) says that "many strong voices may be silenced for ever " if awards of £2,500 a year are made a reward for silence.Dr. Avison was right in his prophecy, but it was fulfilled before he made it.The voices were already silenced and the village Hampdens up and down the country were already burnishing up their images so as to be in line for this apparent bonanza for which the rest of us in general practice will have to pay in one
Balloon-assisted insertion of a cholangioscope into the common bile duct: a novel technique
Authors: A. Mori, H. Tatebe, N. Ohashi, T. Maruyama, K. Sakai, T. Shibuya, M. Okuno
Journal: Endoscopy (2008)

The feasibility of the application of an ultrathin endoscope in direct cholangioscopy and endoscopic retrograde cholangiopancreatography has been reported recently [1] [2] [3] [4]. However, difficulties are occasionally encountered when inserting a scope into the common bile duct because the scope is sometimes pushed too far downward in the duodenum ([Fig. 1 a, b]). We report here a novel technique of balloon-assisted insertion of an ultrathin scope into the common bile duct.