Botulism Associated with Clostridium botulinum Sinusitis after Intranasal Cocaine Abuse
Authors: David B. Kudrow
Journal: Annals of Internal Medicine (1988)

Brief Reports15 December 1988Botulism Associated with Clostridium botulinum Sinusitis after Intranasal Cocaine AbuseDavid B. Kudrow, MD, Dan A. Henry, MD, David A. Haake, MD, Ginder Marshall, MD, Glenn E. Mathisen, MDDavid B. Kudrow, MDSearch for more papers by this author, Dan A. Henry, MDSearch for more papers by this author, David A. Haake, MDSearch for more papers by this author, Ginder Marshall, MDSearch for more papers by this author, Glenn E. Mathisen, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-12-984 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWound botulism has been identified as a risk of parenteral cocaine abuse (1-3). We report a case of botulism associated with maxillary sinusitis after intranasal cocaine abuse; Clostridium botulinum was subsequently cultured from the maxillary sinus.A 25-year-old obese man developed headache, diplopia, and disequilibrium one day before admission, followed by dysphonia, dysarthria, dysphagia, increasing weakness, and ataxia. There was a 7-day history of rhinorrhea and sore throat. He had used intranasal cocaine only twice, most recently 10 days earlier, at which time he used one eighth of a gram of cocaine. The cocaine and all food eaten during the...References1. MacDonaldCohenBlake KMP. The changing epidemiology of adult botulism in the United States. Am J Epidemiol. 1986;124:794-9. CrossrefMedlineGoogle Scholar2. MacDonaldRutherfordFriedman KGS. Botulism and botulism-like illness in chronic drug abusers. Ann Intern Med. 1985;102:616-8. LinkGoogle Scholar3. RapoportWatkins SP. Descending paralysis resulting from occult wound botulism. Ann Neurol. 1984;16:359-61. CrossrefMedlineGoogle Scholar4. . Botulism in the United States, 1899-1977. Handbook for Epidemiologists, Clinicians, and Laboratory Workers. May, 1979. Google Scholar5. Cherington M. Botulism: ten year experience. Arch Neurol. 1974;30:432-7. CrossrefMedlineGoogle Scholar6. HikesManoli DA. Wound botulism. J Trauma. 1981;21:68-71. CrossrefMedlineGoogle Scholar7. MersonDowell MV. Epidemiologic, clinical and laboratory aspects of wound botulism. N Engl J Med. 1973;289:1005-10. CrossrefMedlineGoogle Scholar8. Schweitzer V. Osteolytic sinusitis and pneumomediastinum: deceptive otolaryngologic complications and cocaine abuse. Laryngoscope. 1987;96:206-10. Google Scholar9. GilmanGoodmanRallMurad ALTF. The Pharmacological Basis of Therapeutics. 7th ed. New York: MacMillan; 1985:309. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From Olive View Medical Center, Sylmar; and UCLA School of Medicine, Los Angeles, California. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByShot by a Gun … Missed by a ProviderBotulismClostridiumBotulism (Clostridium botulinum)Shooting up: the interface of microbial infections and drug abuseBotulismClostridium botulinum (Botulism)Botulism as a Potential Agent of BioterrorismBiology and Genomic Analysis of Clostridium botulinumWound botulism from heroin skin poppingTERRESTRIAL BIOTOXINSChapter 1 The most vulnerable synapse: historic aspects of neuromuscular junction disordersCocaïneBotulism in Patients Who Inhale Cocaine: The First Cases in FranceOpinion of the Scientific Panel on biological hazards (BIOHAZ) related to Clostridium spp in foodstuffsWound botulism in the UK and IrelandLess Common Causes of Quadriparesis and Respiratory FailureCocaineNew methods to investigate infectious disease transmission and pathogenesis — Staphylococcus aureus disease in drug usersNeurologic Complications of Substance AbuseNeuromuscular Junction DisordersClostridium botulinum and the OphthalmologistClinical spectrum of botulismACUTE NEUROLOGIC COMPLICATIONS OF DRUG AND ALCOHOL ABUSERespiratory toxicities from stimulant useAPPROACH TO GENERALIZED WEAKNESS AND PERIPHERAL NEUROMUSCULAR DISEASEWound Botulism Associated with Black Tar HeroinStimulant-Induced Pulmonary ToxicityInfections Other than AIDSA recent reminder of botulismRespiratory Complications of Cocaine AbuseCentral nervous system stimulants and anorectic agentsRecent Developments in the Understanding of the Pathogenesis and Treatment of Anaerobic InfectionsBotulism as a Potential Agent of Bioterrorism 15 December 1988Volume 109, Issue 12Page: 984-985KeywordsBotulismClostridiumCocaineHeadachesInfectious diseasesNeurologyOverweightPharyngitisPrevention, policy, and public healthToxins Issue Published: 15 December 1988 PDF DownloadLoading ...