tbuckley/cabot-search huggingface dataset:
Financial Support of Our Growing Medical Schools
Authors: Carleton B. Chapman
Journal: JAMA (1968)

Adequate financing of our growing medical schools at a time when the nation is in fiscal turmoil is probably not possible. This is one aspect of the dangerous crisis we have reached in medical education. The other aspect is even more fundamental; it has to do with the educational philosophy on which our projections of fiscal need are based. It is with this feature that I propose to deal. Many groups, within the past year, have come up with estimates of the monetary amounts we now need to grow and develop. About all that these estimates have in common is that they are large—up to $400 million annually. These efforts are of value chiefly in the emphases they place. It is probably not very useful at this time to attempt to deal with detailed breakdowns of the financial aspects of the estimates. The crisis might be nothing more than
Internet-Based Education for Health Professionals—Reply
Authors: David A. Cook
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risk of Cardiovascular Diseases Is Increased Even with Mild Diabetic Retinopathy
Authors: Ryo Kawasaki, Shiro Tanaka, Sachiko Tanaka, Sachi Abe, Hirohito Sone, Koutaro Yokote, Shun Ishibashi, Shigehiro Katayama, Yasuo Ohashi, Yasuo Akanuma, Nobuhiro Yamada, Hidetoshi Yamashita
Journal: Ophthalmology (2012)
Conduction over an isthmus of atrial myocardium in vivo: a possible model of Wolff-Parkinson-White syndrome.
Authors: H Inoue, D P Zipes
Journal: Circulation (1987)

Antiarrhythmic drugs appear preferentially to prolong refractoriness of accessory pathways compared with atrial or ventricular muscle in patients with the Wolff-Parkinson-White syndrome. This response may be due to intrinsic properties of accessory pathways or to depressed conduction associated with a narrow strip, or isthmus, of tissue. To test the latter possibility, in 16 anesthetized dogs we surgically isolated a portion of the right atrial myocardium in the form of an ellipse (10 to 25 X 8 to 15 mm). The ellipse was connected to the body of the right atrium by a narrow isthmus (cross-sectional area [CSA] 1 to 13.5 mm2) and was perfused by the sinus node artery or its branch. Diastolic threshold (mean +/- SE 0.16 +/- 0.05 vs 0.13 +/- 0.02 mA) and effective refractory period (ERP; 144 +/- 4 vs 139 +/- 5 msec) were the same proximal and distal to the isthmus. In eight dogs, determination of the ERP of the isthmus was limited by the ERP of the atrial tissue proximal and distal to the isthmus, and the CSA of the isthmus in these dogs was significantly larger than that in the remaining seven dogs in which the ERP of the isthmus could be determined (7.4 +/- 1.4 vs 3.2 +/- 0.6 mm2, p less than .05). The shortest pacing cycle length (PCL) with 1:1 conduction from the proximal to the distal segments did not differ from that in the opposite direction in 16 dogs (154 +/- 9 vs 153 +/- 7 msec). The CSA of the isthmus correlated inversely with the shortest PCL with 1:1 conduction in both directions via the isthmus (r = -.84, p less than .01). Vagal stimulation shortened the shortest PCL with 1:1 conduction from the distal to the proximal segment (153 +/- 14 vs 143 +/- 12 msec, p less than .02), but not in the opposite direction. Procainamide (10 to 20 mg/kg iv, serum concentration 8.6 +/- 0.8 micrograms/ml) prolonged the ERP of the proximal site from 145 +/- 5 to 170 +/- 5 msec (p less than .001), the ERP of the distal site from 143 +/- 6 to 168 +/- 6 msec (p less than .001) in 12 dogs, and the shortest PCL with 1:1 conduction (proximal to distal from 149 +/- 8 to 204 +/- 17 msec, p less than .001; distal to proximal from 149 +/- 7 to 197 +/- 12 msec, p less than .001) in 14 dogs.(ABSTRACT TRUNCATED AT 400 WORDS)
Clinical, angiographic and procedural correlates of quantitative coronary dimensions after directional coronary atherectomy
Authors: Jeffrey J. Popma, Nicoletta B. De Cesare, Stephen G. Ellis, David R. Holmes, Cass A. Pinkerton, Patrick Whitlow, Spencer B. King, Ziyad M.B. Ghazzal, Eric J. Topol, Kirk N. Garratt, Dean J. Kereiakes
Journal: Journal of the American College of Cardiology (1991)
Monday Morning Clinic
Authors: Abigail Zuger
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Actinic keratoses and the epidermis on which they arise
Authors: A.D. PEARSE, R. MARKS
Journal: British Journal of Dermatology (1977)

The appearance of the epidermis and epidermal autoradiographic labelling indices were compared in actinic keratoses and paralesional skin in seventeen patients after injection of tritiated thymidine. The skin on the buttock area was also studied as a "non-sun exposed" control. Labelling indices obtained from skin removed after 1 hwere as follows: actinic keratoses 17-4%; paralesional skin 11-2%; buttock skin 5-4%. Many of the epidermal cells in the keratoses that incorporated tritiated thymidine were bizarre and not restricted to the basal or suprabasal regions but were scattered through the thickness of the epidermis. Paralesional skin also showed epidermal thickening and cytological abnormalities including the formation of multinucleate epidermal cells. These findings suggest that the development of actinic keratoses takes place in epidermis that is itself abnormal. The changes suggest that there is a gradual stepwise progression of sun damage epidermis via the clinically obvious keratosis to squamous cell epithelioma.
Adenoassociated Virus Serotype 9-Mediated Gene Therapy for X-Linked Adrenoleukodystrophy
Authors: Yi Gong, Dakai Mu, Shilpa Prabhakar, Ann Moser, Patricia Musolino, JiaQian Ren, Xandra O Breakefield, Casey A Maguire, Florian S Eichler
Journal: Molecular Therapy (2015)

X-linked adrenoleukodystrophy (X-ALD) is a devastating neurological disorder caused by mutations in the ABCD1 gene that encodes a peroxisomal ATP-binding cassette transporter (ABCD1) responsible for transport of CoA-activated very long-chain fatty acids (VLCFA) into the peroxisome for degradation. We used recombinant adenoassociated virus serotype 9 (rAAV9) vector for delivery of the human ABCD1 gene (ABCD1) to mouse central nervous system (CNS). In vitro, efficient delivery of ABCD1 gene was achieved in primary mixed brain glial cells from Abcd1-/- mice as well as X-ALD patient fibroblasts. Importantly, human ABCD1 localized to the peroxisome, and AAV-ABCD1 transduction showed a dose-dependent effect in reducing VLCFA. In vivo, AAV9-ABCD1 was delivered to Abcd1-/- mouse CNS by either stereotactic intracerebroventricular (ICV) or intravenous (IV) injections. Astrocytes, microglia and neurons were the major target cell types following ICV injection, while IV injection also delivered to microvascular endothelial cells and oligodendrocytes. IV injection also yielded high transduction of the adrenal gland. Importantly, IV injection of AAV9-ABCD1 reduced VLCFA in mouse brain and spinal cord. We conclude that AAV9-mediated ABCD1 gene transfer is able to reach target cells in the nervous system and adrenal gland as well as reduce VLCFA in culture and a mouse model of X-ALD.
P1200 EFFECTIVENESS OF TRIPLE THERAPY WITH BOCEPREVIR OR TELAPREVIR IN A MULTICENTRE CLINICAL PRACTICE COHORT OF HCV TREATMENT-EXPERIENCED PATIENTS WITH ADVANCED HEPATIC FIBROSIS. SVR-12W AFTER TREATMENT
Authors: C. Fernández, P. Muñoz de Rueda, S. Alonso, M. Prieto, A. Martín-Álvarez, J. Pons, J. Pascasio, M. Serra, M. Romero, P. Conde, I. Carmona, M. Diago, M. Testillano, J. Navarro-Jarabo, J. Sanchez Ruano, J. Sousa, F. Nogueras, R. Granados, G. Sánchez Antolín, R. Andrade, H. Hallal, M. Martí Arribas, M. del Moral, J. Salmerón
Journal: Journal of Hepatology (2014)
A unique ectonucleotide pyrophosphohydrolase associated with porcine chondrocyte-derived vesicles.
Authors: I Masuda, J Hamada, A L Haas, L M Ryan, D J McCarty
Journal: Journal of Clinical Investigation (1995)

Previous studies have shown increased nucleotide pyrophosphohydrolase (EC 3.6.1.8) (NTPPHase) activity in detergent extracts of degenerated human cartilage containing calcium pyrophosphate dihydrate (CPPD) crystals relative to those from osteoarthritis or normal cartilage. NTPPHase was later shown to be an ectoenzyme and its activity was increased in synovial fluid from patients with CPPD crystal deposits relative to fluids from other types of arthritis. We have purified a soluble 61-kD NTPPHase from conditioned media of organ-cultured porcine articular cartilage to electrophoretic homogeneity. Its NH2-terminal sequence through 26 cycles showed < 30% homology to any previously reported protein sequence. An antibody raised to a synthetic peptide corresponding to this sequence reacted with denatured but not native enzyme. This antibody reacted against a sedimentable vesicle-associated 127-kD protein in conditioned media from cultured articular cartilage or from chondrocytes in primary monolayer culture and against a series of soluble proteins in conditioned media supernatant, including a 61-kD protein representing our original isolate. No reactivity was found in 1% SDS extracts of washed cultured chondrocytes, although these contained greater NTPPHase activity than the conditioned media. Antibody to PC-1, another ectoNTPPHase, reacted with 1% SDS extracts of whole chondrocytes but not against those chromatographic fractions containing the major portion of NTPPHase activity. Release of the vesicle-associated 127-kD enzyme into conditioned medium was stimulated three- to sevenfold by TGF beta 1. The antibody also reacted with a series of soluble proteins and with 127-kD sedimentable protein in human synovial fluid. Kinetic studies supported the existence of a unique vesicle-associated NTPPHase; apparent Km (mM) of chondrocyte membrane NTPPHase was 1.5 and 3.0 at pH 7.3 and 9.88, respectively; apparent Km (mM) of vesicle associated NTPPHase was 0.83 and 1.28 at pH 7.3 and 9.88. The data suggest the existence of a unique ecto-NTPPHase associated with vesicles derived from normal articular cartilage.
Zinc Concentration in Esophageal Biopsy Specimens Measured by X-Ray Fluorescence and Esophageal Cancer Risk
Authors: C. C. Abnet, B. Lai, Y.-L. Qiao, S. Vogt, X.-M. Luo, P. R. Taylor, Z.-W. Dong, S. D. Mark, S. M. Dawsey
Journal: JNCI Journal of the National Cancer Institute (2005)

Background: In rodents, zinc deficiency potentiates the effects of certain nitrosamines that act as esophageal carcinogens. Studies of the association between zinc and esophageal squamous cell carcinoma in humans have been hampered by plasma zinc homeostasis, which obscures individual differences in total zinc stores, and by the uncertainty regarding zinc bioavailability when estimating dietary zinc intake because phytate from whole grains effectively prohibits zinc absorption. By using baseline tissue biopsy specimens collected in a prospective observational study, we determined the association between incident esophageal squamous cell carcinoma and baseline element concentrations in tissue sections from residents of Linzhou, China, participating in a nutrition intervention trial. Methods: We used x-ray fluorescence spectroscopy to measure zinc, copper, iron, nickel, and sulfur concentrations in single 5-μm-thick sections from formalin-fixed, paraffin-embedded esophageal biopsy specimens collected in 1985 from 60 eventual case and 72 control subjects. Subjects were matched on baseline histology and followed for 16 years. We used Cox proportional hazards models to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between each element and risk of incident esophageal cancer. All statistical tests were two-sided. Results: The risk of developing esophageal cancer was much lower for subjects in the highest quartile of esophageal tissue zinc concentration compared with those in the lowest quartile (HR = 0.21, 95% CI = 0.065 to 0.68). The association was statistically significant across quartiles ( Ptrend = .015). Individuals in the highest quartile of sulfur concentration had a lower risk of esophageal cancer than individuals in the lowest quartile (HR = 0.29, 95% CI = 0.095 to 0.85), but the association across quartiles was not statistically significant ( Ptrend = .081). There was no association between copper, iron, or nickel concentrations and risk of esophageal cancer. Conclusion: High tissue zinc concentration was strongly associated with a reduced risk of developing esophageal squamous cell carcinoma. X-ray fluorescence spectroscopy can be used to assess relationships among concentrations of both nutritional and toxic elements and disease risk in banked tissue specimens.
Diagnostic Decision: The Erythrocyte Sedimentation Rate: Guidelines for Rational Use
Authors: HAROLD C. SOX
Journal: Annals of Internal Medicine (1986)

The erythrocyte sedimentation rate (ESR) is seldom the sole clue to disease in asymptomatic persons and is not a useful screening test. When the rate is increased, a careful history and physical examination will generally disclose the cause. An unexplained increase in the ESR is generally transitory and seldom due to serious disease. The test is most useful in diagnosing temporal arteritis and monitoring the patient's response to treatment. The test has little diagnostic value in rheumatoid arthritis but may be useful in monitoring disease activity when clinical findings are equivocal. The ESR is often normal in patients with cancer, infection, and connective tissue disease and is therefore of little use in excluding these diseases in patients with vague complaints.
HB-EGF/HER-1 signaling in bone marrow mesenchymal stem cells: inducing cell expansion and reversibly preventing multilineage differentiation
Authors: Mauro Krampera, Annalisa Pasini, Antonella Rigo, Maria Teresa Scupoli, Cristina Tecchio, Giorgio Malpeli, Aldo Scarpa, Francesco Dazzi, Giovanni Pizzolo, Fabrizio Vinante
Journal: Blood (2005)
Obesity and Age of First Non–ST-Segment Elevation Myocardial Infarction
Authors: Mohan C. Madala, Barry A. Franklin, Anita Y. Chen, Aaron D. Berman, Matthew T. Roe, Eric D. Peterson, E. Magnus Ohman, Sidney C. Smith, W. Brian Gibler, Peter A. McCullough
Journal: Journal of the American College of Cardiology (2008)
Three Cases of Cardiospasm Treated Successfully with Psychotherapy
Authors: George Spyros Philippopoulos
Journal: Psychotherapy and Psychosomatics (1975)

3 cases of cardiospasm successfully treated by psychotherapy are reported and some catamnestic conclusions and remarks are given after a follow-up of the patients for 10, 9 and 8 years, respectively. Unlike the clinical symptomatology, which was almost identical in all 3 cases, the precipitating factors, the deeper meaning and the unconscious symbolism of the symptoms were quite different but specific for each one of the patients. Some more thoughts are also given in the paper with reference to the clinical criteria to be considered when evaluating the final therapeutic results of the technique of the therapy applied.
Vasoconstriction: tightening the noose through MMPs
Authors: J. S. Isenberg, S. Shiva
Journal: Cardiovascular Research (2009)

Arterial tone is dependent on a balance between agents that lead to relaxation of arterial vascular smooth muscle cells (VSMCs) and agents that cause contraction of the same. The process of contraction at a mechanical level requires interaction of structural proteins including myosin light chain 2 (MLC2) and actin. The interaction of these leads to force transduction and cell shortening, ultimately causing vessel diameter narrowing and increased resistance to blood flow. Physiological vasoconstrictors, such as norepinephrine, work through binding cell receptors on VSMCs and activating G-protein-coupled receptors (GPCRs). These in turn interact with several classes of heterotrimeric G-proteins to affect a diverse range of cell responses.1,2 Phenylephrine, a synthetic surrogate of physiological agonists like norepinephrine, acts to induce vasoconstriction by binding to adrenergic receptors (α1) and activating Gαq, which in turn increases phospholipase C (PLC) activity and formation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). These events result in the release of calcium from intracellular stores ( Figure 1 ).



Figure 1 
GPCR signalling modulation of vasoconstriction. Acutely, vasoconstrictor agonists transmit their … 



*Corresponding authors: 10048 Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA. Tel: +1 412 383 5424; fax: +1 412-383-9009 (J.S.I). 10041 Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA. Tel: +1 412 383 5854; fax: +1 412-383-5888 (S.S.) E-mail address : jsi5{at}pitt.edu (J.S.I); sss43{at}pitt.edu (S.S.).
Disruption of palladin leads to defects in definitive erythropoiesis by interfering with erythroblastic island formation in mouse fetal liver
Authors: Xue-Song Liu, Xi-Hua Li, Yi Wang, Run-Zhe Shu, Long Wang, Shun-Yuan Lu, Hui Kong, Yue-E Jin, Li-Jun Zhang, Jian Fei, Sai-Juan Chen, Zhu Chen, Ming-Min Gu, Zhen-Yu Lu, Zhu-Gang Wang
Journal: Blood (2007)
Haemophilus influenzae Meningitis in Adults
Authors: S. J. Eykyn, R. D. Thomas, I. Phillips
Journal: BMJ (1974)

Haemophilus influenzae meningitis though common in childhood is rarely seen in the adult. During the past four years eight cases of H. influenzae meningitis have been seen in St. Thomas's Hospital and four of these were in patients over 20 years old. There was a possible predisposing condition in two patients. In each case there was difficulty in identification of the organism in the Gram-stained film of the cerebrospinal fluid deposit.
Seafarers and HIV infection
Authors: J. Taylor
Journal: BMJ (1991)

are also of great importance.These include other tropical diseases such as leishmaniasis5; autoimmune diseases, particularly rheumatoid arthritis9; some forms of cancer"'; and pathogenic and opportunistic mycobacterial infections, especially in patients with AIDS."Political and narrowly defined economic factors, rather than world health, seem to be the determining factors in the development of drugs, allowing orphan drugs and diseases to be glibly dismissed owing to failure of will by the world community.The possibility of developing new compounds from thalidomide that are much more selectively active than the parent molecule has also not been exhausted.4I believe that it is necessary for all concerned with global health to press for such development.
Abstract 658: CBS9106 is a novel low toxic reversible oral CRM1 inhibitor with CRM1 degrading activity
Authors: Keiichi Sakakibara, Naoya Saito, Takuji Sato, Atsushi Suzuki, Yoko Hasegawa, Jonathan M. Friedman, Masashi Suganuma, Donald W. Kufe, Daniel D. VanHoff, Tadahiko Iwami, Takumi Kawabe
Journal: Cancer Research (2011)

Abstract CRM1 plays an important role in the nuclear export of cargo proteins bearing Nuclear Exporting Signal sequences. Leptomycin B (LMB), a well-known irreversible inhibitor of CRM1, possesses strong anti-tumor properties, however, its toxicity prevents it from being clinically useful. In this study, we show that a novel compound, CBS9106, inhibits CRM1-dependent nuclear export and induces G1-arrest and apoptosis in time- and dose-dependent manner in a broad-spectrum of cancer cells including multiple myeloma cells. IC50s of growth inhibition by CBS9106 (48h) are in the range from 46.7 to 366 nM in multiple myeloma cell lines (MM.1R, MM.1S, ARH-77 and RPMI-8226). In contrast with LMB, CBS9106 acts reversibly and reduces CRM1 protein without affecting the mRNA expression level. CBS9106-dependent reduction of CRM1 is abolished by MG132, a proteasome inhibitor. Pretreatment of cells with LMB suppresses CBS9106-induced CRM1 degradation. Moreover, CBS9106-biotin captured CRM1 in a pull down analysis and the amount of CRM1 captured by CBS9106-biotin was reduced by LMB treatment and vice versa. These results suggest that CBS9106 acts on the domain of CRM1 that includes LMB's covalent binding site at Cys-528, leading to proteasome-dependent CRM1 degradation. Oral administration of CBS9106 significantly suppressed tumor growth and prolonged survival duration in xenograft model mice. It caused prolonged reduction of CRM1 protein in tumor xenografts without showing significant body weight loss. Taken together, the results indicate that CBS9106 is a novel CRM1 inhibitor and a promising clinical candidate. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 658. doi:10.1158/1538-7445.AM2011-658