tbuckley/cabot-search huggingface dataset:
A comparison of posterior wall thickness, interventricular septum thickness and relative wall thickness of left ventricle of heart in male athletes (badminton and karate) and non-athletes
Authors: Hasan Abdi, Alireza Hajighasemi, Seyed Mostafa Tayebisany
Journal: British Journal of Sports Medicine (2010)

The aim of this study was to study a comparison of posterior wall thickness, interventricular septum thickness and relative wall thickness of left ventricle of heart in male athlete and non–athlete, and to investigate the effect of selected submaximal tests for estimating of VO 2 max (because of frequently use of them), as submaximal short duration activities, on ST segment changes in active young men. For this purpose, 20 healthy men were randomly selected from the athletics at Shahrood city. They had at least 3 years experience in regular physical activity and sport participation. Measurements were made during four consecutive days (every day, 10:00). At the 1st day, age (23.4±1.8 years), height (173.2±3.5 cm), weight (68.7±4.1 kg) and pretest ECGs were recorded. Subjects performed PWC 195 test, Katch-McArdle step test and Astrand ergometer test at 2nd, 3rd and 4th days, randomly. Immediately after the tests, post-test ECGs were recorded. Data were analysed using paired-sample t test (for comparison between pretest and each of post-tests) and one-way analysis of variance (for comparison among post-tests). Statistical significances were accepted at p&lt;0.001 and p&lt;0.05. Analysis of data indicated that all of three tests had significant effects on ST segment voltage (p&lt;0.001). Also, there were no significant differences between mean ST segment voltages of post-tests (p&lt;0.05) (rest: 0.051±0.019, PWC 195 test 0.024±0.012, Katch-McArdle step test 0.024±0.014, Astrand ergometer test 0.024±0.007 mv(. Our findings suggest that submaximal short duration activities (and tests) statistically reduce the voltage of ST segment, but, these depressions are not pathologically significant, because they were less than 0.1 mv.
Personality and Psychopathology in Patients with Temporomandibular Joint Pain-Dysfunction Syndrome
Authors: G.N. Meldolesi, A. Picardi, E. Accivile, R. Toraldo di Francia, M. Biondi
Journal: Psychotherapy and Psychosomatics (2000)

Our aim was to deepen the understanding of the psychosomatic aspects of temporomandibular joint (TMJ) pain dysfunction syndrome. Patients affected by this syndrome were compared with both healthy subjects and psychiatric patients, using both self-report and physician-scored psychological measures.Three sex- and age-matched groups were recruited: a TMJ group (n = 32), a healthy group (n = 22) and a psychiatric group (n = 22). The psychiatric group consisted of outpatients diagnosed as having a DSM-IV anxiety or depressive disorder of mild to moderate severity. Psychometric assessment included the Minnesota Multiphasic Personality Inventory (MMPI) and the Hamilton Anxiety Rating Scale (HARS).Psychiatric patients scored higher than both the comparison groups on all but one of the MMPI scales; the majority of the differences were significant or approached significance. TMJ patients scored higher than healthy controls on the Hs (hypochondriasis; p< or =0.01), Hy (hysteria; p< or =0.01) and D (depression; p< or =0.05) scales. Psychiatric patients scored higher than TMJ patients on the HARS psychic anxiety subscale (p< or =0.05), while TMJ patients scored higher than psychiatric patients on the somatic anxiety subscale (p< or = 0.05).Certain personality characteristics were associated with TMJ dysfunction. However, further longitudinal studies should be performed to properly assess causal relationships. Despite signs of neuroticism, anxiety and depression, patients with TMJ dysfunction differed from anxious and depressed patients. While the latter displayed a higher level of psychopathology, each group was characterised by a distinct pattern of anxiety symptoms. In addition, a substantial proportion of TMJ patients had little awareness of their inner states and emotions.
Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis.
Authors: C Niederau, R A Liddle, L D Ferrell, J H Grendell
Journal: Journal of Clinical Investigation (1986)

The effects of the cholecystokinin (CCK)-receptor antagonist proglumide, the protease inhibitor gabexate, and the hormones secretin and cholecystokinin-octapeptide (CCK-8) were studied in a model of acute hemorrhagic pancreatitis induced by feeding mice a choline-deficient, ethionine-supplemented (CDE) diet. Injections of gabexate and proglumide from initiation of CDE diet (before induction of pancreatitis) increased survival from 37% (diet alone) to 85 and 75%, respectively, and also ameliorated histological alterations and increases in serum amylase concentration and pancreatic activated trypsin. Secretin had no major beneficial effect. When proglumide or gabexate were given after induction of pancreatitis, proglumide still increased survival to 75%, whereas gabexate no longer did. Injection of nontoxic doses of CCK-8 before proglumide or gabexate injections completely abolished all beneficial effects and also increased the severity of pancreatitis due to CDE diet alone. Blockade of CCK receptors and early inhibition of protease activity may be beneficial in severe acute pancreatitis. Cholecystokinin appears to play a contributory role in the development of pancreatitis.
Topical 5-fluorouracil in the treatment of Darier's disease
Authors: A.C. KNULST, H. BAART FAILLE, W.A. VLOTEN
Journal: British Journal of Dermatology (1995)

Journal Article Topical 5‐fluorouracil in the treatment of Darier's disease Get access A.C. KNULST, A.C. KNULST Department of Dermatology, University Hospital Utrecht, PO Box 85500, 3508 GA Utrecht, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar H. BAART DE LA FAILLE, H. BAART DE LA FAILLE Department of Dermatology, University Hospital Utrecht, PO Box 85500, 3508 GA Utrecht, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar W.A. VAN VLOTEN W.A. VAN VLOTEN Department of Dermatology, University Hospital Utrecht, PO Box 85500, 3508 GA Utrecht, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 133, Issue 3, 1 September 1995, Pages 463–466, https://doi.org/10.1111/j.1365-2133.1995.tb02679.x Published: 01 September 1995 Article history Accepted: 05 October 1994 Published: 01 September 1995
Significance of Streptococcus bovis Endocarditis
Authors: Saeed Ahmad
Journal: Annals of Internal Medicine (1993)

Letters1 April 1993Significance of Streptococcus bovis EndocarditisSaeed Ahmad, MDSaeed Ahmad, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-7-199304010-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Tornos and colleagues [1] found three cases of Streptococcus bovis endocarditis but appeared not to search for bowel carcinoma, the presumed cause of death in one patient a year after the endocarditis was cured. The importance of differentiating group D streptococci by species and of performing stool cultures for S. bovis in this clinical setting cannot be overemphasized.REFERENCE1. Tornos MP, Permanyer-Miralda G, Olona M, Gil M, Galve E, Almirante B, et al. Long-term complications of native valve infective endocarditis in non-addicts. A 15-year follow-up study. Ann Intern Med. 1992; 117:567-72. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1993Volume 118, Issue 7Page: 572KeywordsEndocarditisGroup A streptococciStreptococcus Issue Published: 1 April 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Deconstructing endothelial dysfunction: soluble guanylyl cyclase oxidation and the NO resistance syndrome
Authors: Mark T. Gladwin
Journal: Journal of Clinical Investigation (2006)

In this issue of the JCI, Stasch and colleagues suggest that a novel drug, BAY 58-2667, potently activates a pool of oxidized and heme-free soluble guanylyl cyclase (sGC; see the related article beginning on page 2552). The increased vasodilatory potency of BAY 58-2667 the authors found in a number of animal models of endothelial dysfunction and in human blood vessels from patients with diabetes suggests that there exists a subphenotype of endothelial dysfunction characterized by receptor-level NO resistance. Diseases associated with NO resistance would appear to be ideally suited for therapies directed at restoring redox homeostasis, sGC activity, and NO sensitivity.
ED-20 * THE INCIDENCE OF PEDIATRIC BRAIN TUMORS WITHIN THE SCOTT AND WHITE INTEGRATED HEALTHCARE HEALTH SYSTEM
Authors: S. Mukherjee, C. S. peddaboina, E. Ebwe, J. Udaikumar, R. Shephard, K. Newell-Rogers, S. Singel, E. Fonkem
Journal: Neuro-Oncology (2014)

INTRODUCTION: Pediatric brain tumors are the second most common childhood tumor. The purpose of this study was to determine how the outcome of pediatric brain tumor is affected by different factors such as age, geographic location, brain tumor type, tumor grade and ethnicity. METHODS: We conducted a retrospective analysis of pediatric brain patient with the Scott and White brain tumor registry from 1978-2011. Data was analyzed based on age, race, treatment year, residential areas and tumor types. Univarate and multivariable survival analyses were performed, in addition to SAS 9.2. RESULTS: There were 159 patients treated within Scott and White brain tumor registry 1978-2011. The median survival time of the combination of the 5 tumor types (N = 101) is 147.12 months (95% CI (79.61-260.73)). The median survival times and concurrent 95% confidence intervals of pilocytic Astrocytomas, Ependymomas, malignant Gliomas, medulloblastomas, and oligodendrogliomas are respective and as follows: no available survival time with 95% CI 109.04 months; median survival of 182.51 mo and 95% CI 15.28mo; median survival of 14.26 mo and 95% CI 11.70 mo; median survival of 115.35 mo and 95% CI (22.70-260.73 mo); median survival not available with 95% CI 5.52 mo. The median of the follow-up time of the combination of the 5 tumor types (N = 101) is 104 months. For the patients who survived (N = 58), the median of the follow-up time is 73.17 months, the minimum is 3.06 months, and the maximum is 298.61 months. Finally, with an increase in age, we observed a concurrent increase in median survival time. We observed no difference among other factors. CONCLUSION: This study suggests that pediatric brain tumors are frequently diagnosed within the Scott & White Integrated Health Care System. Patient age was associated with increased survival time while other factors such as race/ethnicity were not.
Possible Association between Triphasic E.E.G. Waves and Disorder of Dopaminergic Systems
Authors: A. M. Hamoen
Journal: BMJ (1973)

In a patient probably suffering from Jakob-Creutzfeldt disease of the Jones-Nevin type and in another with a cerebral infarction treatment with amantadine (Symmetrel) 100 mg twice a day caused repetitive triphasic waves to disappear from the E.E.G. in each case. In view of these findings and the fact that some other conditions in which repetitive triphasic E.E.G. waves are a clinical feature greatly improve on treatment with levodopa, the suggestion is made that these waves result from a disorder of the dopaminergic system.
Building Blocks
Authors: Jody W. Zylke
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Trainee from Abroad
Authors: ALTON I. SUTNICK
Journal: Annals of Internal Medicine (1968)

Editorials1 May 1968The Trainee from AbroadALTON I. SUTNICK, M.D., F.A.C.P.ALTON I. SUTNICK, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1127 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn medical center and community hospital alike, foreign house officers have been assuming an increasing role in recent years. In 1966 to 1967, 14,735 foreign medical graduates were in training programs in the United States (1), and they are now responsible for 35% of the patient care in our hospitals. Dacso, Antler, and Rusk (2) in this issue of the ANNALS point out that the performance and accomplishments of the foreign medical graduate are proportional to both his adaptation to life in the United States and his fluency in the English language. To foreign resident physicians unfamiliar with the American...References1. Medical education in the United States. Prepared by the staff of the American Medical Association's Departments of Allied Health Professions and Services, Continuing Medical Education, Graduate Medical Education, and Undergraduate Medical Education. JAMA 202: 165, 1967. Google Scholar2. DACSO MM, ANTLER L, and RUSK HA: The foreign medical resident training in the United States. Ann. Intern. Med. 68: 1105, 1968. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALTON I. SUTNICK, M.D., F.A.C.P.Affiliations: The Institute for Cancer Research Fox Chase Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInternational Medical Graduates in Rural America: The 1987 Distribution of Physicians Who Entered the U.S. Medical System Between 1969 and 1982Clarifying the LiteratureMore Notes on Recent ANNALS ThemesE. J. H.Medical Ambassadors 1 May 1968Volume 68, Issue 5Page: 1127-1128KeywordsGraduate medical educationPatients ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...
Decision Analysis
Authors: William B. Schwartz
Journal: New England Journal of Medicine (1979)

During nearly a decade of trying to bring decision analysis into clinical use, I have been impressed by the negative reactions of many students and physicians. On ward rounds, at lectures and at morning report the technic is disparaged, and its day-to-day use in patient cafe resisted. Decision analysis is said, among other things, to take too much time to apply, to require spurious quantification and to be dehumanizing. I have also encountered another layer of concerns, expressed less readily, which seem to be based on apprehension over the effect that the widespread use of decision analysis will have on . . .
Broken Mercury Thermometers
Authors: F. A. Herrero
Journal: JAMA (1973)

<h3>To the Editor.—</h3> In their letter to the editor, Mofenson and Greensher (223: 559, 1973) reported the hazards of using mercury thermometers in children. We would like to add that parents should be advised to be careful while using thermometers in children not only "because of the hazard of broken glass," but also because of the dangers of mercury spillage. A fairly large number of reports emphasize the volatility of mercury, large surface area resulting from relatively minor spills, and difficulty of completely decontaminating surfaces on which mercury has accumulated as factors in creating metallic mercury poisoning.<sup>1</sup>Substantially higher concentrations of mercury vapor than the ambient natural background concentration has been found in homes where mercury has been spilled as a result of broken thermometers.<sup>2</sup>
A Novel Antiinflammatory Role for Andrographolide in Asthma via Inhibition of the Nuclear Factor-κB Pathway
Authors: Zhang Bao, Shouping Guan, Chang Cheng, Songlian Wu, Siew Heng Wong, D. Michael Kemeny, Bernard P. Leung, W. S. Fred Wong
Journal: American Journal of Respiratory and Critical Care Medicine (2009)

Persistent activation of nuclear factor (NF)-kappaB has been associated with the development of asthma. Andrographolide, the principal active component of the medicinal plant Andrographis paniculata, has been shown to inhibit NF-kappaB activity.We hypothesized that andrographolide may attenuate allergic asthma via inhibition of the NF-kappaB signaling pathway.BALB/c mice sensitized and challenged with ovalbumin (OVA) developed airway inflammation. Bronchoalveolar lavage fluid was assessed for total and differential cell counts, and cytokine and chemokine levels. Serum IgE levels were also determined. Lung tissues were examined for cell infiltration and mucus hypersecretion, and the expression of inflammatory biomarkers. Airway hyperresponsiveness was monitored by direct airway resistance analysis.Andrographolide dose-dependently inhibited OVA-induced increases in total cell count, eosinophil count, and IL-4, IL-5, and IL-13 levels recovered in bronchoalveolar lavage fluid, and reduced serum level of OVA-specific IgE. It attenuated OVA-induced lung tissue eosinophilia and airway mucus production, mRNA expression of E-selectin, chitinases, Muc5ac, and inducible nitric oxide synthase in lung tissues, and airway hyperresponsiveness to methacholine. In normal human bronchial epithelial cells, andrographolide blocked tumor necrosis factor-alpha-induced phosphorylation of inhibitory kappaB kinase-beta, and downstream inhibitory kappaB alpha degradation, p65 subunit of NF-kappaB phosphorylation, and p65 nuclear translocation and DNA-binding activity. Similarly, andrographolide blocked p65 nuclear translocation and DNA-binding activity in the nuclear extracts from lung tissues of OVA-challenged mice.Our findings implicate a potential therapeutic value of andrographolide in the treatment of asthma and it may act by inhibiting the NF-kappaB pathway at the level of inhibitory kappaB kinase-beta activation.
Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction
Authors: Thomas P. Kraehenbuehl, Lino S. Ferreira, Alison M. Hayward, Matthias Nahrendorf, André J. van der Vlies, Eliza Vasile, Ralph Weissleder, Robert Langer, Jeffrey A. Hubbell
Journal: Biomaterials (2010)
Blue Baby Due to Methemoglobinemia
Authors: Robert J. Haggerty
Journal: New England Journal of Medicine (1962)

IN addition to congenital heart disease, with right-to-left shunts, and chronic lung disease, cyanosis in babies can be caused by methemoglobinemia. The congenital variety, of course, is lifelong, but several toxins may produce an acute, acquired variety. Nitrites (used as food preservatives or in well water), aniline dyes, acetanilid, pyridium, dinitrophenol and potassium chlorate‡ have all been recognized as producing this. Recently, benzocaine and its derivatives have been added to this list, as the following case§ demonstrates.A 1-month-old male infant was admitted to the hospital because of increasing blue color, restlessness and irritability. He had been well except for . . .
Detection of somatic muscle fasciculation on electrocardiograms.
Authors: D J Thomas, D O Williams
Journal: BMJ (1976)

Small discrete spikes appearing on the electrocardiogram (ECG) of a man with a pacemaker turned out to be fasciculation potentials picked up from leg muscles. To find out how common these spikes were all routine ECGs made in one month were reviewed. Spike potentials were found in six patients, and in each case they originated from somatic musculature. Spikes could nearly always be detected on ECGs that were recorded subsequently in patients known to have lower motor neurone lesions that produced fasciculation. Thus the presence of these fasciculation spikes may suggest underlying neuromuscular disease; this possibility should be recognised by those who record ECGs so that the spikes are not suppressed by overuse of the filter.
Digital Rectal Examination Screening for Prostate Cancer
Authors: James V. Maloney
Journal: JAMA (1993)

To the Editor.  —Gerber et al 1 found that patients who participate in a digital rectal examination screening program at regular intervals have a higher disease-specific mortality than those whose prostate cancer is identified on an initial examination. The observation appears to contradict the conventional wisdom that early detection and treatment of cancer result in a higher survival rate. They conclude, Annual digital rectal examination alone may be insufficiently frequent and/or sensitive to prevent significant mortality from this disease. In their perspicacious discussion they offer alternative explanations, including speculation on the role of tumor growth rate.  Analogous findings in screening for breast cancer suggest the apparent benefit of screening in many cancer studies is due to bias introduced in the study by the unrecognized effect of tumor growth rate in the study cohorts. Two decades ago a study of visits to a breast screening clinic indicated that the 5-year survival
The Goulstonian Lectures ON AUTO-INTOXICATION: ITS RELATION TO CERTAIN CARDIO-VASCULAR DISORDERS: Delivered before the Royal College of Physicians of London on March 13th, 15th, and 20th, 1906
Authors: H. B. Shaw
Journal: BMJ (1906)

AFTER some introductory-remarks the lecturer said:] It is the object of these leetures to consider the possible 'effects due to auto-intoxication when from any cause the organs and tissues of the body are made to disintegrate;to study the effects of the dissolution of cells of various organs and tissues as shown by the toxic 'effects of their 'products, restricting myself in the main to the considera- ltion 'ol the products of proteid and nucleo-proteid degradation, including not only the deep degradation products but those more vital agencies a study of which is only -possible when we examine the effects produced by freslh tissues; that is, tissues which, thouglh disintegrated by mechanical means, may be.considered still living tissue in so far as tile formation of their, deep disintegration pro- ducts has not yet begun. BLOOD PRESSURE IN HEALTH AND DISEASE.[Dr.Shaw then described observations on blood pressu c in patients at different ages and in healthy youths, made -vitli the Riva-Rocci sphygmomanometer, the details of which are contained in the subjoined tables.]TABLE I.-Systolic Blood Pressure in Infirmary Patients (Men in Recumbeney).Aige systolic in Pressure.Yeaks.49 46 55 .