tbuckley/cabot-search huggingface dataset:
Artificial insemination has few untoward effects
Authors: John Henahan
Journal: JAMA (1983)

A brief summary is provided of studies presented at the Eleventh World Congress of Fertility and Sterility on the effects of artificial insemination on parents and children. Three studies found that couples who underwent artificial insemination were as satisfied with their marriages and their sex lives as couples who achieved parenthood normally. One investigator reported that children conceived through artificial insemination, whether with frozen or nonfrozen sperm, performed better than the norm in intelligence and psychomotor tests.
Hyperglycemia After Myocardial Infarction
Authors: Paresh Dandona, Ahmad Aljada, Arindam Bandyopadhyay
Journal: Diabetes Care (2003)

We appreciate the comments of Dhatariya (1) in this issue of Diabetes Care . Clearly, insulin is the ultimate anabolic hormone that may not only keep inflammation at bay, but also regulate the appropriate utilization of metabolites such that it conserves protein and …
Asthma increase could be caused by paracetamol use, study says
Authors: O. Dyer
Journal: BMJ (2001)

The results of the world's largest asthma study seem to discount the notion that environmental allergens could account for the huge variation in asthma rates across Europe.

The research, published in the September issue of the European Respiratory Journal (2001;18:598-611), identifies no single cause for the much higher rates of the disease in some countries but links paracetamol use with increased susceptibility to asthma.

The European community respiratory health survey was a cross sectional study of atopy, asthma, and other chronic respiratory disorders that was carried out in 22 countries around the world (though mostly in Europe) during the early 1990s and that involved some 140 000 participants.

Its most startling finding was the …
Functional Magnetic Resonance Imaging of the Brain
Authors: Denis Le Bihan
Journal: Annals of Internal Medicine (1995)

This conference reviewed the potential scope of application for recently developed techniques for functional magnetic resonance imaging (fMRI) of the brain.The most successful technique is based on the sensitivity of magnetic resonance imaging (MRI) to magnetic effects caused by the modulation of the oxygenation state of hemoglobin, which is induced by local variations in blood flow during task activation. Typically, the MRI signal increases by a few percentage points during brain activation because blood flow and oxygen supply sharply increase. Brain activation images with excellent combined spatial and temporal resolution have been obtained noninvasively using visual, sensorimotor, or auditory stimuli, or during higher-order cognitive processes such as language or mental imagery. Although sensitive to misregistration artifacts and macroscopic vessels, MRI permits both the direct correlation of function with underlying anatomy and repeated studies on the same person. It may become the method of choice for studies of mental and cognitive processes, presurgical mapping, monitoring recovery from stroke or head injuries, exploration of seizure disorders, or monitoring the effects of neuropharmaceuticals.
Peripatetic Pseudoporphyria
Authors: C. Basil Williams
Journal: New England Journal of Medicine (1961)

THE colorful appellation of Munchausen's syndrome was coined by Asher1 in 1951 to denote peregrinating patients with extraordinary complaints. Subsequent accounts by Gawn and Kauffmann,2 Chapman3 and Clarke and Melnick4 have outlined the diabolical machinations such patients may employ to obtain hospitalization. The following case is reported because the lurid history is uniquely ingenious, and dissemination of this story and pictures may save countless hospitals and physicians needless expense and embarrassment.Case ReportE.T., a 36-year-old fisherman allegedly en route from Alaska to Massachusetts, reported to the Salt Lake County General Hospital Emergency Room on September 28, 1960, complaining of . . .
AIDS and the lung: update 1992. 2. Recent developments in the management of the pulmonary complications of HIV disease.
Authors: D M Mitchell, R F Miller
Journal: Thorax (1992)

Infection with the human immunodeficiency virus continues to spread worldwide at an alarming rate.'Once infection with HIV has occurred treatment can only palliate the infec- tious and other complications of HIV disease.The development of an effective vaccine is the focus of much current research but is still awaited, whereas prevention of HIV infection raises numerous problems, and prevention programmes have not so far halted the spread of HIV.Respiratory physicians in all parts of the world will therefore continue to see increasing numbers of HIV infected individuals and to treat the respiratory complications.The purpose of these two update articles, the first of which was published in the last issue (p 305), is to review changes in perspective that have occurred regarding the pulmonary manifestations of HIV disease over the last two years since the series "AIDS and the Lung" appeared in Thorax, and also to highlight areas of importance that were not fully covered in those articles-inevitably selective as this is a wide subject and many changes have occurred, but attempting to focus on areas of particular interest or importance.
Interleukin-17 Accelerates Allograft Rejection by Suppressing Regulatory T Cell Expansion
Authors: Satoshi Itoh, Naoyuki Kimura, Robert C. Axtell, Jeffrey B. Velotta, Yongquan Gong, Xi Wang, Naoki Kajiwara, Aya Nambu, Eri Shimura, Hideo Adachi, Yoichiro Iwakura, Hirohisa Saito, Ko Okumura, Katsuko Sudo, Lawrence Steinman, Robert C. Robbins, Susumu Nakae, Michael P. Fischbein
Journal: Circulation (2011)

Background— Interleukin-17 (IL-17), which is predominantly produced by T helper 17 cells distinct from T helper 1 or T helper 2 cells, participates in the pathogenesis of infectious, autoimmune, and allergic disorders. However, the precise role in allograft rejection remains uncertain. In the present study, we investigated the role of IL-17 in acute allograft rejection using IL-17-deficient mice. Methods and Results— Donor hearts from FVB mice were heterotopically transplanted into either C57BL/6J-IL-17-deficient (IL-17 − / − ) or -wild-type mice. Allograft survival was significantly prolonged in IL-17 − / − recipient mice due to reduced local inflammation accompanied by decreased inflammatory cell recruitment and cytokine/chemokine expression. IL-17 − / − recipient mice exhibited decreased IL-6 production and reciprocally enhanced regulatory T cell expansion, suggesting a contribution of regulatory T cells to prolonged allograft survival. Indeed, allografts transplanted into anti-CD25 mAb-treated IL-17 − / − recipient mice (regulatory T cell-depleted) developed acute rejection similar to wild-type recipient mice. Surprisingly, we found that gamma delta T cells rather than CD4 + and CD8 + T cells were key IL-17 producers in the allografts. In support, equivalent allograft rejection was observed in Rag-2 −/− recipient mice engrafted with either wild-type or IL-17 − / − CD4 + and CD8 + T cells. Finally, hearts transplanted into gamma delta T cell-deficient mice resulted in decreased allograft rejection compared with wild-type controls. Conclusions— During heart transplantation, (1) IL-17 is crucial for acceleration of acute rejection; (2) IL-17-deficiency enhances regulatory T cell expansion; and (3) gamma delta T cells rather than CD4 + and CD8 + T cells are a potential source of IL-17. IL-17 neutralization may provide a potential target for novel therapeutic treatment for cardiac allograft rejection.
The Other Side of the Bed Rail
Authors: Mary O'Flaherty Horn
Journal: Annals of Internal Medicine (1999)

On Being a Patient1 June 1999The Other Side of the Bed RailMary O'Flaherty Horn, MDMary O'Flaherty Horn, MDSt. Mary Medical Center; Long Beach, CA 90813-3393 (Horn)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-11-199906010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I had certainly been in large medical centers before; there was no reason to feel overwhelmed. I myself am a well-trained internist from a large university—I knew the scene—but this summer morning was different. I was tired and scared. Just 2 weeks before, I had been told that the slurred speech that had been progressing for several months was probably caused by amyotrophic lateral sclerosis (ALS). They'd said 2 to 5 years, and as a physician I knew all too well the grim prognosis and disheartening lack of effective therapy associated with my diagnosis. At the urging of my family, ... Author, Article, and Disclosure InformationAuthors: Mary O'Flaherty Horn, MDAffiliations: St. Mary Medical Center; Long Beach, CA 90813-3393 (Horn)Note: Dr. Horn died at home on 10 August 1998. Peter V. Barrett, MD, revised the manuscript after her death.Corresponding Author: Peter V. Barrett, MD, St. Mary Medical Center, 1050 Linden Avenue, Long Beach, CA 90813-3393. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe physician's disease: The impact of medical knowledge on personal illnessLife on the Receiving End: A Qualitative Analysis of Health Providers??? Illness NarrativesPearls and Pitfalls in Patient Care: Need to Revive Traditional Clinical ValuesCaring for ColleaguesPerspectives on Palliative Care: A Chair of Medicine Viewpoint 1 June 1999Volume 130, Issue 11Page: 940-941KeywordsAmyotrophic lateral sclerosisElectromyographyHipKneesMotor neuronsMuscles ePublished: 15 August 2000 Issue Published: 1 June 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Changing the Presumption: Providing ART to Vaccine Research Participants
Authors: Ruth Macklin
Journal: The American Journal of Bioethics (2006)

Click to increase image sizeClick to decrease image size Notes 1. The consultation, in which I participated, took place in Geneva at WHO headquarters in 1998. Since I did not obtain permission from the source to cite this remark, the individual who made it remains unidentified. This assumption was by made by some participants at a WHO-UNAIDS consultation on providing access to ART for vaccine participants, Geneva, Switzerland, July 2003. I was a participant in the consultation and this observation is based on notes I took at the meeting.
Abstract 3428: Effect of a non cardiotoxic Doxorubicin analog, 13-deoxy, 5-imino doxorubicin on decatenation of DNA by Topoisomerase II.
Authors: Nicole Frank, Richard Olson, Gerald M. Walsh, Todd Talley, Barry Cusack
Journal: Cancer Research (2013)

Abstract Anthracyclines such as doxorubicin are widely used to treat solid and hematological cancers. However, within the course of treatment they have the potential to cause life threatening chronic cardiotoxicity which limits their potential use. The cause of cardiotoxicity is not thoroughly understood, with previous research indicating the generation of reactive oxygen species and free iron accumulation as possible causes for cardiomyocyte death. Recent publications have shown the interaction between doxorubicin and Topoisomerase IIβ plays a key role in anthracycline induced cardiotoxicity. Topoisomerase enzymes are utilized during the coiling and uncoiling of DNA within the cell and are active targets of anthracyclines not only in tumoricidal action (Topoisomerase IIα) but also in the pathogenesis of cardiotoxicity (Topoisomerase IIβ). In this research we seek to further evaluate the interaction between doxorubicin, doxorubicin analogues and Topoisomerase IIβ. The analogues were selected due to previous chronic in vivo experiments in rabbits where classical manifestations of cardiotoxicity (including reduced left ventricular shortening fraction and pathological changes in cardiac tissue) were not observed. Furthermore, one analogue (13-deoxy, 5-imino doxorubicin) has shown promising clinical data suggesting a strong antineoplastic effect without the cardiotoxic effects. Doxorubicin and this analogue were placed in the presence of catenated DNA for 6 hours at 37°C prior to exposure to Topoisomerase IIα and β enzymes. The reaction was allowed to proceed for 30 minutes at 37°C and analyzed for decatenation of the DNA by the enzyme. This experiment was then repeated in cardiac H9c2 cells to assay possible differential inhibition at the cellular level. Citation Format: Nicole Frank, Richard Olson, Gerald M. Walsh, Todd Talley, Barry Cusack. Effect of a non cardiotoxic Doxorubicin analog, 13-deoxy, 5-imino doxorubicin on decatenation of DNA by Topoisomerase II. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3428. doi:10.1158/1538-7445.AM2013-3428
Abstract 1523: MALDI mass spectrometry imaging for on-tissue spatial profiling of tumor-specific N-linked glycans and lipids in renal carcinomas.
Authors: Richard R. Drake, Thomas Powers, Ellen Jones, Raymond S. Lance, Anand S. Mehta, Dean A. Troyer
Journal: Cancer Research (2013)

Abstract Pathologic staging of renal clear cell carcinoma (ccRCC) provides useful but limited prognostic information suggesting that there are underlying molecular processes not readily identified through conventional histopathological techniques in the primary tumor. At the molecular level, transcript, metabolomic and protein expression patterns have indicated a striking Warburg Effect profile in ccRCC tissues, with major affects on sugar and lipid metabolism. Our group has been applying MALDI-MS imaging approaches to ccRCC tissues to profile lipids and glycans associated with disease progression. As both lipids and glycans can act as signaling molecules and have been associated with cancer progression, ccRCC tissues were selected by a pathologist to contain substantial tumor, non-tumor and tumor margin regions to characterize the differential localization of lipid and glycan species within the tissue. Lipid profiles from fresh-frozen tissue slides coated in DHB matrix were obtained on a dual source Bruker Solarix 70 FTICR mass spectrometer. Glycans were imaged in a similar fashion with a method developed by our lab using protein N-glycanase F to release protein bound N-glycans. There are clear patterns of specific lipid and glycan species that are only present along the margin of the tumor and non-tumor interface, or those primarily localized in non-tumor or tumor regions. Off-tissue extraction of lipids and glycans from similarly processed tissues and further mass spectrometry analysis was done to confirm structural designations. Linkage of differentially expressed lipid and glycan species with clinical data and other molecular markers of ccRCC is ongoing. This approach has the potential to not only improve prognostic assessment and enhance post-operative surveillance, but also to better define the underlying biology of ccRCC aggressiveness and identify new rational targets for therapeutic intervention. Citation Format: Richard R. Drake, Thomas Powers, Ellen Jones, Raymond S. Lance, Anand S. Mehta, Dean A. Troyer. MALDI mass spectrometry imaging for on-tissue spatial profiling of tumor-specific N-linked glycans and lipids in renal carcinomas. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1523. doi:10.1158/1538-7445.AM2013-1523
COMPARATIVE EFFECTIVENESS OF BLEEDING AVOIDANCE THERAPIES IN PCI PATIENTS: ANALYSIS FROM THE NATIONAL CARDIOVASCULAR DATA REGISTRY®
Authors: Steven P. Marso, Amit Amin, John A. House, Kevin F. Kennedy, John A. Spertus, Sunil V. Rao, David J. Cohen, John C. Messenger, John S. Rumsfeld
Journal: Journal of the American College of Cardiology (2010)
Cancer of the GI tract: Colon, rectum, anus. Epidemiology and etiology
Authors: D. P. Burkitt
Journal: JAMA (1975)

ALL AVAILABLE epidemiologic evidence must be considered in any attempt to formulate an adequate hypothesis for the possible cause of large-bowel tumors. <h3>Geographic and Racial Distribution.—</h3> The incidence of cancer of the colon and rectum is related to economic development more closely than any other form of cancer is; the highest incidence occurs in the most sophisticated areas of North America and in the more industrialized countries of Northern Europe, where it is the second commonest cause of death from cancer, bronchial carcinoma being the most common. The lowest incidence is in rural communities in Africa; intermediate levels occur in India and South America.<sup>1,2</sup> Genetic factors are not likely to play a major role since the present prevalence of the disease is closely comparable in white and black Americans; in many countries, urban communities are significantly more affected than are people in rural areas. <h3>Relationship to Other Noninfective Diseases</h3>
Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors
Authors: Naoya Takayama, Hidekazu Nishikii, Joichi Usui, Hiroko Tsukui, Akira Sawaguchi, Takashi Hiroyama, Koji Eto, Hiromitsu Nakauchi
Journal: Blood (2008)
Elevated Serum Pepsinogen I: A Genetic Marker for Duodenal-Ulcer Disease
Authors: Morton I. Grossman
Journal: New England Journal of Medicine (1979)

It has long been suspected that genetic factors play an important part in duodenal-ulcer disease because the incidence is increased among first-degree relatives.1 However, until now, no strong genetic marker for the disease had been identified. It has been known that patients with duodenal ulcer have an increased frequency of blood Group O and of the nonsecretor status of ABH antigens in saliva, but these associations are weak. Edwards2 calculated that the ABO locus contributed about 1 per cent of the total variance in duodenal ulcer, and secretor status about 1.5 per cent.In this issue of the Journal, . . .
High security facilities must not be closed until viable alternatives are in place
Authors: K. Sayal, A. Maden
Journal: BMJ (1999)

EDITOR—The future of special hospitals, including the possibility of closure, has been much debated.1 2 Although it is assumed that up to one third of the current 1400 patients could be managed in long term medium security,3 most of the research underpinning this assumption may be out of date.4 Special hospitals have tightened their admission criteria and have fewer elderly patients than they used to; these patients have been replaced by younger and more dangerous patients. …
Reviews and Notes: Adolescent Medicine: The Practice of Medicine in Adolescence
Authors: Laura S. Sadowski
Journal: Annals of Internal Medicine (1994)

Literature of Medicine1 July 1994Reviews and Notes: Adolescent Medicine: The Practice of Medicine in AdolescenceLaura S. SadowskiLaura S. SadowskiUniversity of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7110.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-1-199407010-00036 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Practice of Medicine in AdolescenceCharles G. D. Brook; ed. 283 pages. London: Edward Arnold; 1993. $95.00.How should we provide medical care to adolescent patients? Thorough knowledge of the health problems that affect adolescents and an appropriate clinical approach to adolescent patients are essential to providing excellent medical care to this group. Adolescents are rarely ill with traditional ailments. Instead, the major causes of death and disability among adolescents are the consequences of their health behaviors, such as tobacco, alcohol, and drug use; sexual experimentation; diet; exercise; and use of injury-protection devices. These behaviors also lead to morbidity ... Author, Article, and Disclosure InformationAuthors: Laura S. SadowskiAffiliations: University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7110. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1994Volume 121, Issue 1 Page: 79 Keywords Adolescent medicine Adolescents Behavior Chlamydia infection Disabilities Gonorrhea Infectious diseases Pelvic inflammatory disease Sickle cell disease Sports ePublished: 15 August 2000 Issue Published: 1 July 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A SERIES OE MISTAKEN DIAGNOSES GYNECOLOGIC DIAGNOSES.
Authors: THOMAS S. CULLEN
Journal: JAMA (1904)

While it is advisable to chronicle our successes in diagnosis and treatment, I think it is equally necessary for us occasionally to look back and see where we have failed to make an accurate diagnosis before operation, or to critically review our judgment in a given case to ascertain if, in a subsequent and similar case, we could not do better. From a perusal of the literature one is often led to believe that the exact nature of abdominal tumors is easily determined before operation. While this is undoubtedly true in the greater number of cases, yet it is well to remember that in a goodly number of instances, before operation, it is only possible to determine that the operation is necessary, the exact nature of the malady only being ascertainable when the abdomen is opened. From the accompanying group of cases, which I report in detail, the surgeon who
EXPERIMENTAL LATHYRISM IN THE CHICK EMBRYO
Authors: Serge D. Orloff, Jerome Gross
Journal: The Journal of Experimental Medicine (1963)

1. C(14)-labeled beta-aminopropionitrile distributed throughout the egg contents within 10 minutes postinjection. By ion exchange chromatography and electrophoretic analysis three major components of the extractable dialyzable radioactive material could be demonstrated, representing at least 80 per cent of the total. The acidic and basic components were identified as beta-aminopropionitrile and cyanoacetic acid, while the fraction isoelectric at pH 5.3, consisting of two components, remained unidentified. 2. Less than 1 molecule of betaAPN per 100 molecules of protein was present in the highly purified extractable lathyritic bone collagen indicating that binding of the lathyrogen is not a factor in collagen extractability. 3. The proximity of betaAPN to collagen in bone is not essential to its extractability. 4. The effect of incubation temperature of the embryo on collagen extractability suggests the involvement of a metabolic process in this phenomenon.
THE SWINE LUNGWORM AS A RESERVOIR AND INTERMEDIATE HOST FOR SWINE INFLUENZA VIRUS
Authors: Richard E. Shope
Journal: The Journal of Experimental Medicine (1955)

Twenty-five swine, infested with lungworms infected with masked swine influenza virus, were exposed to adverse weather conditions on one or more occasions. Of these, 4 came down with apparent swine influenza, while 6 others developed serological evidence of infection with swine influenza virus. The remaining 15 prepared swine, as well as 8 lungworm-free control swine, failed to show evidence of swine influenza virus infection, despite repeated exposures to adverse weather. The data presented indicate that, in the 10 swine in which swine influenza virus infections were elicited, some feature of the weather to which the animals were exposed was responsible for provoking masked influenza virus to infectivity. The exact constituent of the meteorological complex comprising "weather", responsible for the provocation, cannot be determined from the data obtained.
Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial
Authors: Eric Nisbet-Brown, Nancy F Olivieri, Patricia J Giardina, Robert W Grady, Ellis J Neufeld, Romain Séchaud, Axel J Krebs-Brown, Judith R Anderson, Daniele Alberti, Kurt C Sizer, David G Nathan
Journal: The Lancet (2003)