tbuckley/cabot-search huggingface dataset:
Diseases of the Lung: Radiologic and Pathologic Correlations
Authors: Paul E. Epstein
Journal: Annals of Internal Medicine (2003)

Medical Writings: Book Notes16 December 2003Diseases of the Lung: Radiologic and Pathologic CorrelationsPaul E. Epstein, MDPaul E. Epstein, MDFrom University of Pennsylvania, Philadelphia, Pennsylvania.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-12-200312160-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Muller NL, Fraser RS, Lee KS, and Johkoh T. 387 pages. Philadelphia: Lippincott Williams & Wilkins; 2003. $149.00. ISBN 0781734355. Order phone 800-638-3030.Field of medicine: Pulmonary diseases.Format: Hardcover book.Audience: Pulmonary clinicians, radiologists, and pathologists with an interest in diseases of the lung.Purpose: To present the most common diseases of the pulmonary parenchyma and the airways of the lung as they appear radiographically and pathologically in order to correlate the findings of these 2 diagnostic methods.Content: The book contains 20 chapters, each describing a separate disease process that affects the lungs. These include congenital abnormalities, infections, ... Author, Article, and Disclosure InformationAffiliations: From University of Pennsylvania, Philadelphia, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Pharmazeutische Betreuung von Patienten mit Hypertonie: Was ist beim Einsatz von Beta-Adrenozeptorenblockern zu beachten? 16 December 2003Volume 139, Issue 12Page: 1048KeywordsConnective tissue diseasesInterstitial lung diseasesLung and intrathoracic tumorsLungsMetabolic disordersPulmonary diseasesRadiologistsSoftware toolsThoraxVentilators ePublished: 16 December 2003 Issue Published: 16 December 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age
Authors: Hans Bisgaard, Nan Li, Klaus Bonnelykke, Bo Lund Krogsgaard Chawes, Thomas Skov, Georg Paludan-Müller, Jakob Stokholm, Birgitte Smith, Karen Angeliki Krogfelt
Journal: Journal of Allergy and Clinical Immunology (2011)
Informed consent (and a flutter in Vegas)
Authors: David Rowbotham
Journal: BMJ (2005)

“I need your consent for this. Now as you know, even after transoesophageal echocardiography, there's still a small risk of stroke.”

Stroke. That word seemed louder than the rest. She carried on talking, but I heard nothing else. Stroke? I had to be strong for my wife (and she was feeling just the same towards me). So there we were, being silently strong together.

Let me backtrack. A short trip to Las Vegas had been unexpectedly complicated by an immediate flurry of ectopic beats after I had rapidly drunk an ice cold beer. Now, that's not unusual. I get ectopics most nights if I lie on my right side (although the left side is fine—I have never been able to work that out). But ectopics after a cold drink? This was new. The ectopics persisted throughout the day, uncomfortable and irritating. Then, that night, I awoke with a start. Something was wrong. I clutched at my carotid pulse. I was in atrial fibrillation. But how could this be? I'm young and …
Azithromycin once daily for 1 year reduced acute COPD exacerbations
Authors: Jay Peters, Antonio Anzueto
Journal: Annals of Internal Medicine (2012)

ACP Journal Club17 January 2012Azithromycin once daily for 1 year reduced acute COPD exacerbationsJay Peters, MD, Antonio Anzueto, MDJay Peters, MDUniversity of Texas Health Science Center, San Antonio, Texas, USA (J.P., A.A.), Antonio Anzueto, MDUniversity of Texas Health Science Center, San Antonio, Texas, USA (J.P., A.A.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-2-201201170-02010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationAlbert RK, Connett J, Bailey WC, et al; COPD Clinical Research Network. Azithromycin for prevention of exacerbations of COPD. N Engl J Med. 2011;365:689-98. https://pubmed.ncbi.nlm.nih.gov/21864166Clinical Impact RatingsGIM/FP/GP: Pulmonology: References1 Friedlander AL, Albert RK. Chronic macrolide therapy in inflammatory airways diseases. Chest. 2010;138:1202-12. [PMID: 21051396] Google Scholar2 Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for the Diagnosis, Management and Prevention of COPD (GOLD) 2010. www.goldcopd.org/guidelines-global-strategy-for-diagnosis-management.html (accessed 17 Nov 2011). Google Scholar Author, Article, and Disclosure InformationAuthors: Jay Peters, MD; Antonio Anzueto, MDAffiliations: University of Texas Health Science Center, San Antonio, Texas, USA (J.P., A.A.)This article was published at Annals.org on 3 January 2012. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAzithromycin ameliorated cigarette smoke-induced airway epithelial barrier dysfunction by activating Nrf2/GCL/GSH signaling pathwayLong-term macrolide therapy for chronic obstructive pulmonary disease: a population-based time series analysisThe design of novel classes of macrolides for neutrophil-dominated inflammatory diseasesChronic Obstructive Pulmonary Disease: Official diagnosis and treatment guidelines of the Czech Pneumological and Phthisiological Society; a novel phenotypic approach to COPD with patient-oriented care 17 January 2012Volume 156, Issue 2Page: JC1-10KeywordsAntibioticsBacterial pathogensChronic obstructive pulmonary diseaseHearingHospitalizationsMortalityNeutrophilsPulmonary medicineQuality of lifeQuestionnaires ePublished: 17 January 2012 Issue Published: 17 January 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cost and the Common Cold
Authors: Frederick G. Hayden
Journal: Annals of Internal Medicine (1997)

Letters15 January 1997Cost and the Common ColdFrederick G. Hayden, MD and Louis Diamond, PhDFrederick G. Hayden, MDUniversity of Virginia School of Medicine, Charlottesville, VA 22908University of Colorado School of Pharmacy, Denver, CO 80262Search for more papers by this author and Louis Diamond, PhDUniversity of Virginia School of Medicine, Charlottesville, VA 22908University of Colorado School of Pharmacy, Denver, CO 80262Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-2-199701150-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Mr. Vermeulen that prescribing decisions must be sensitive to cost issues. It is important to emphasize, however, that concern about economic factors should not deter clinical investigations designed to advance the understanding of pathogenic mechanisms and development of more effective therapy. Our study was conducted several years before (and submitted for publication several months before) intranasal ipratropium was approved by the Food and Drug Administration. Our results were not intended to endorse use of this product but rather to indicate its degree of clinical effectiveness and tolerability in adults with uncomplicated colds. Clearly, many health ...References1. Mainous AG, Heuston WJ, Clark JR. Antibiotics and upper respiratory infection: do some folks think there is a cure for the common cold? J Fam Pract. 1996; 42:357-61. Google Scholar2. Wald TG, Shult P, Krause P, Miller BA, Drinka P, Gravenstein S. A rhinovirus outbreak among residents of a long-term care facility. Ann Intern Med. 1995; 123:588-93. Google Scholar3. Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ. 1995; 310:1225-8. Google Scholar4. McMillan JA, Weiner LB, Higgins AM, Macknight K. Rhinovirus infection associated with serious illness among pediatric patients. Pediatr Infect Dis J. 1993; 12:321-5. Google Scholar5. Sung BS, Chonmaitree T, Broemeling LD, Owen MJ, Patel JA, Hedgpeth DC, et al. Association of rhinovirus infection with poor bacteriologic outcome of bacterial-viral otitis media. Clin Infect Dis. 1993; 17:38-42. Google Scholar Author, Article, and Disclosure InformationAuthors: Frederick G. Hayden, MD; Louis Diamond, PhDAffiliations: University of Virginia School of Medicine, Charlottesville, VA 22908University of Colorado School of Pharmacy, Denver, CO 80262 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1997Volume 126, Issue 2Page: 174KeywordsAntibioticsCommon coldLower respiratory tract infectionsLungsMorbidityOtitis mediaPathogensPulmonary diseasesRespiratory systemRhinovirus infection ePublished: 15 August 2000 Issue Published: 15 January 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Prognostic Value of Immunocytologic Detection of Bone Marrow Metastases in Neuroblastoma
Authors: Thomas J. Moss, C. Patrick Reynolds, Harland N. Sather, Stephen G. Romansky, G. Denman Hammond, Robert C. Seeger
Journal: New England Journal of Medicine (1991)

Morphologic evaluation of bone marrow for neuroblastoma cells is a routine and important component of clinical staging. Specific immunostaining of malignant cells with monoclonal antibodies should be more sensitive, however, and may improve the detection of metastases and provide additional prognostic information.We looked for tumor cells in bone marrow from 197 patients with newly diagnosed neuroblastoma, using immunoperoxidase staining with monoclonal antibodies (immunocytologic analysis) and examination of smears and specimens obtained by trephine biopsy (conventional analysis).Routine smears and trephine-biopsy specimens were positive for tumor cells in 46 percent of the patients, whereas 67 percent were positive on immunocytologic analysis (P less than 0.0001). Immunocytologic analysis detected bone marrow metastases in 34 percent of patients considered to have only localized or regional disease (Stage I, II, or III). It also identified tumor cells that were not detected by conventional analysis in patients with widespread disease (Stage IV or IVS). Tumor content, as determined by immunocytologic analysis, predicted clinical outcome in relation to the age of the patient at diagnosis. Patients with Stage II or III disease diagnosed after one year of age who did not have occult marrow metastases did well, whereas those with metastases did poorly (P = 0.006). Patients in whom Stage IV disease was diagnosed before they were one year of age did well if bone marrow metastases were few or absent, but had poor survival if the marrow contained more than 0.02 percent tumor cells (P = 0.03).Immunocytologic analysis of bone marrow aspirates is more sensitive than conventional analysis in detecting tumor cells and provides prognostic information. The relations among marrow metastases, age at diagnosis, and clinical outcome illustrate the biologic heterogeneity of neuroblastoma.
Arginine vasopressin gene regulation in the homozygous Brattleboro rat.
Authors: J K Kim, F Soubrier, J B Michel, L Bankir, P Corvol, R W Schrier
Journal: Journal of Clinical Investigation (1990)

The Brattleboro rat, which has an autosomally recessive form of diabetes insipidus, has been reported to have a marked defect in the regulation of arginine vasopressin (AVP) gene expression. However, it is not known whether this is a primary genetic defect or occurs secondary to the urinary water losses which occur in the absence of circulating AVP in the Brattleboro rat. This present study was therefore undertaken to study AVP gene regulation in the Brattleboro rat after chronic AVP treatment by osmotic minipump for 2 wk. In Brattleboro rats without AVP treatment, neither urinary osmolality (Uosm) nor hypothalamic AVP mRNA was significantly changed after 24 h of fluid deprivation (Uosm, 413 +/- 33 to 588 +/- 44, NS; AVP mRNA, 39.33 +/- 2.95 to 46.39 +/- 2.71 pg/micrograms total RNA, NS). In contrast, when Brattleboro rats were treated with AVP for 2 wk, the regulation of AVP gene occurred in response to 24 h of fluid deprivation. In these studies, hypothalamic AVP mRNA was significantly increased compared with the Brattleboro rats still receiving AVP with free access of water (28.9 +/- 3.5 vs. 65.0 +/- 3.3 pg/micrograms total RNA, P less than 0.001). Further studies in Long-Evans rats demonstrate a similar response to a comparable degree of fluid deprivation as Uosm and AVP mRNA were significantly increased after 72 h of fluid deprivation (Uosm, 1,505 +/- 186 to 5,460 +/- 560 mosmol/kg, P less than 0.001; AVP mRNA, 31.7 +/- 3.9 to 77.5 +/- 4.6 pg/micrograms total RNA, P less than 0.001). These results indicate that AVP-replaced homozygous Brattleboro rats can regulate AVP gene expression normally in response to fluid deprivation. This finding indicates that the defect in AVP gene regulation in the Brattleboro rat not receiving AVP replacement is a secondary phenomenon rather than a primary genetic defect.
High Court quashes tribunal's judgment on police doctor
Authors: C. Dyer
Journal: BMJ (2013)

The High Court has quashed a decision by the Medical Practitioners Tribunal Service to strike a police doctor off the medical register, after finding a “serious procedural irregularity” in the hearing of the case.

Judge Philip Raynor sent the case of Hisham El-Baroudy back to the tribunal service and ordered that his case should be reheard by a fresh panel.

El-Baroudy, who was working as a forensic medical examiner, was called to Chelsea …
An Application of Fetography
Authors: V. Messana
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Aminiography performed with an oil-soluble contrast medium is called fetography.<sup>1</sup>This procedure outlines the fetal surfaces, and thus far has been used to detect fetal soft tissue malformations, to facilitate intrauterine transfusion by outlining the fetal anterior abdominal wall, and occasionally to determine the sex of the fetus.<sup>2</sup> A contrast medium that has a particular affinity for the vernix caseosa is necessary. Only by making evident the vernix on the fetal skin is it possible to obtain a good outline of the fetus. The vernix caseosa disappears from the fetal body surface toward the end of the normal period of gestation, and is always absent from the skin of some dystrophic fetuses.<sup>3</sup> Thus, when fetography fails to visualize the fetal borders, and fragments of vernix caseosa coated by contrast medium appear within the amniotic fluid, one may assume that the fetus is dystrophic or
Recurrent Drug-Induced Liver Injury (DILI) with different drugs in the Spanish Registry: The dilemma of the relationship to autoimmune hepatitis
Authors: M.I. Lucena, N. Kaplowitz, H. Hallal, A. Castiella, M. García-Bengoechea, P. Otazua, M. Berenguer, M.C. Fernandez, R. Planas, R.J. Andrade
Journal: Journal of Hepatology (2011)
Ruptured semimembranosus bursa--an unusual complication following sports injury of the knee.
Authors: F Andersen-Ranberg, N Hejgaard
Journal: British Journal of Sports Medicine (1986)

An exceptional complication of a slight sports injury of the knee with rupture of the semimembranosus bursa in a 29-year-old male football player is reported. The diagnosis was verified by immediate arthrography, consequently the possibility of thrombophlebitis could be ruled out. Anticoagulation is dangerous and contraindicated in rupture of the semimembranosus bursa due to the risk of developing compartment syndrome. Simple bed-rest for a week gave complete relief of pain.
CD11b-mediated migratory property of peripheral blood B cells
Authors: Kazushige Kawai, Nelson H. Tsuno, Mika Matsuhashi, Joji Kitayama, Takuya Osada, Jun Yamada, Takeshi Tsuchiya, Satomi Yoneyama, Toshiaki Watanabe, Koki Takahashi, Hirokazu Nagawa
Journal: Journal of Allergy and Clinical Immunology (2005)
Screening for Cystic Fibrosis-Reply
Authors: Stephen J. Sepe
Journal: JAMA (1983)

In Reply.—  Drs Rosenstein and Langbaum raise an extremely important and valid issue regarding the implementation of newborn screening procedures without prior evaluation of test sensitivity, specificity, and availability of effective therapeutic interventions. In our article entitled Genetic Services in the United States: 1979-1980 (1982;248:1733), we were not advocating at present the screening of newborns for CF, but we were using this disease as an example of one for which new technological development could increase the need for genetic services during pregnancy or shortly after delivery.  New screening technologies should be evaluated not only before routine screening programs are established in a population, but also periodically after they have been in use. The necessity of ongoing evaluation has been illustrated recently with phenylketonuria screening programs. Issues such as timing of specimen collection, biologic variability, and necessity of routine follow-up screening are currently being addressed—almost 20 years after screening was instituted
Peripheral Lesions Identified on Ultrawide Field Imaging Predict Increased Risk of Diabetic Retinopathy Progression over 4 Years
Authors: Paolo S. Silva, Jerry D. Cavallerano, Nour Maya N. Haddad, Hanna Kwak, Kelli H. Dyer, Ahmed F. Omar, Hasanain Shikari, Lloyd M. Aiello, Jennifer K. Sun, Lloyd Paul Aiello
Journal: Ophthalmology (2015)
Autotaxin expression and its connection with the TNF-alpha-NF-κB axis in human hepatocellular carcinoma
Authors: Jian-Min Wu, Yan Xu, Nicholas J Skill, Hongmiao Sheng, Zhenwen Zhao, Menggang Yu, Romil Saxena, Mary A Maluccio
Journal: Molecular Cancer (2010)

Autotaxin (ATX) is an extracellular lysophospholipase D that generates lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC). Both ATX and LPA have been shown to be involved in many cancers. However, the functional role of ATX and the regulation of ATX expression in human hepatocellular carcinoma (HCC) remain elusive. In this study, ATX expression was evaluated in tissues from 38 human HCC and 10 normal control subjects. ATX was detected mainly in tumor cells within tissue sections and its over-expression in HCC was specifically correlated with inflammation and liver cirrhosis. In addition, ATX expression was examined in normal human hepatocytes and liver cancer cell lines. Hepatoma Hep3B and Huh7 cells displayed stronger ATX expression than hepatoblastoma HepG2 cells and normal hepatocytes did. Proinflammtory cytokine tumor necrosis factor alpha (TNF-α) promoted ATX expression and secretion selectively in Hep3B and Huh7 cells, which led to a corresponding increase in lysophospholipase-D activity. Moreover, we explored the mechanism governing the expression of ATX in hepatoma cells and established a critical role of nuclear factor-kappa B (NF-κB) in basal and TNF-α induced ATX expression. Further study showed that secreted enzymatically active ATX stimulated Hep3B cell invasion. This report highlights for the first time the clinical and biological evidence for the involvement of ATX in human HCC. Our observation that links the TNF-α/NF-κB axis and the ATX-LPA signaling pathway suggests that ATX is likely playing an important role in inflammation related liver tumorigenesis.
Glucose-Induced Cyclic AMP Oscillations Regulate Pulsatile Insulin Secretion
Authors: Oleg Dyachok, Olof Idevall-Hagren, Jenny Sågetorp, Geng Tian, Anne Wuttke, Cécile Arrieumerlou, Göran Akusjärvi, Erik Gylfe, Anders Tengholm
Journal: Cell Metabolism (2008)
Volume Determinations in Computed Tomography
Authors: Dean E. Brenner
Journal: JAMA (1982)

Modern computed tomographic (CT) scanners allow reasonably high-resolution cross-sectional visualization of most viscera and masses. To determine the accuracy of CT volume estimation, CT volumes of inanimate objects, cadaver kidneys and spleens, and in vivo balloons were performed. Regions of interest were outlined by a hand-operated cursor, and the computer program calculated the cross-sectional area in square millimeters and in pixels. A second computer program used Simpson's rule to calculate the volume from these multiple cross-sectional areas. Calculated CT volumes were within ±10% of directly measured volumes. Tumor masses being treated by chemotherapy were followed up clinically and by CT. Volume changes determined by CT are believed to be equal to and frequently more sensitive than clinical examination. From our experimental CT and clinical experiences, accuracy can be affected by (1) respiratory movement; (2) rapid changes in in vivo blood volume; (3) low CT number-gradient at the objects' periphery; (4) observer error in cursor tracing of the desired structure; and (5) mathematical errors inherent in Simpson's rule. We conclude that CT can estimate volumes of CT definable masses and can be useful in following tumor response to therapy. (<i>JAMA</i>1982;247:1299-1302)
SAFETY AND EFFICACY OF AAIR PACING IN SELECTED PATIENTS WITH SICK SINUS SYNDROME
Authors: Thiloththama Thisaranie Herath, Janek Senaratne, Diane Beaudette, Marleen Irwin, Sajadhussein Gulamhusein, Manohara Senaratne
Journal: Journal of the American College of Cardiology (2014)
Evaluation of the SAID Teaching Program
Authors: DAVID W. CLINE, JUDITH N. GARRARD
Journal: American Journal of Psychiatry (1973)

Evaluation of a new teaching program suggests that second-year medical students can be taught psychiatry with a multimedia combination of filmed interviews with patients, an inventory of critical symptoms, a diagnostic chart illustrating clustering of symptoms for basic diagnosis, and rapid feedback of faculty evaluation. When compared with controls, experimental subjects did significantly better in evaluating filmed patients, but there was only a trend that they did better when evaluating psychiatric patients at the bedside. The students rated this program as an effective teaching approach.
Cancer in Crohn's disease: dispelling the myths.
Authors: D B Sachar
Journal: Gut (1994)

Cancer in Crohn's disease: dispelling the myths 'The risk of carcinoma developing in Crohn 's disease is well known to be less than that of ulcerative colitis ' 'The trouble with people is not that they don't know, but that they know so much that ain 't so '2