tbuckley/cabot-search huggingface dataset:
Letter by Singh Regarding Article, “Berlin Heart EXCOR Pediatric Ventricular Assist Device for Bridge to Heart Transplantation in US Children”
Authors: Tajinder P. Singh
Journal: Circulation (2013)

The description of the overall Berlin heart EXCOR experience in US children by Almond et al 1 is an important contribution to pediatric heart failure literature.After a careful evaluation of baseline factors and competing outcomes in EXCOR recipients, the authors found that reduced end-organ function-renal or hepatic-was independently associated with death after EXCOR implantation.Using the Schwartz equation to estimate glomerular filtration rate (GFR), 2 children with a GFR value of 30% to 99% predicted for age were assigned the risk category of "moderate renal dysfunction" 1 and were reported to be at higher risk of death after EXCOR compared with children with normal GFR.Although the key message of initiating EXCOR support in children in advanced heart failure before they are too sick is important, it is difficult to accept that either moderate renal dysfunction or the associated mortality risk begins at the GFR value of 99% predicted.Because the normal GFR at any pediatric age is a range of values 3,4 and the normal range used in the study (or a reference for such values) was not provided, it is also unclear whether 100% predicted GFR values were the midpoint or the lower end of some range.These details are important for physicians trying to apply this knowledge in patient selection, in determining optimal timing for EXCOR, or in counseling parents regarding the risk benefit of EXCOR implantation in their child.They will also be important for investigators trying to replicate these results or assess risk factors in future cohorts.Determining optimal timing for initiating mechanical support in children with advanced heart failure will be an important area of research in the next decade.The article by Almond et al 1 provides significant initial insights.
1008-183 Effects of ezetimibe, simvastatin, and ezetimibe-simvastatin on noncholesterol sterol
Authors: Gerd Assmann, Frank Kannenberg, Wayne Weng, John Erbey, Ani John, Diane Tribble, Thomas Musliner, Lesli J Lipka, Enrico P Veltri
Journal: Journal of the American College of Cardiology (2004)
Comment on: Hegde et al. Effect of 3-Month Yoga on Oxidative Stress in Type 2 Diabetes With or Without Complications: A Controlled Clinical Trial. Diabetes Care 2011;34: 2208–2210
Authors: Sandro Sperandei
Journal: Diabetes Care (2012)

I read with great interest the article by Hegde et al. (1), which investigated the effects of 3-month yoga practice on oxidative stress, glycemic control, blood pressure control, and anthropometry in type 2 diabetic patients with or without complications, in comparison with control subjects on standard care. In the face of the increasing prevalence of type 2 diabetes around the world, it is very important to assess different, and perhaps more enjoyable, methods of care. Nevertheless, some statistical issues concerning the results of the cited work need to be clarified.

First, statistical analyses were not clear. The authors stated that they used paired t tests …
Detection by replica plating of false revertant colonies induced in the Salmonella-mammalian microsome assay by hexavalent chromium.
Authors: P Pedersen, E Thomsen, R M Stern
Journal: Environmental Health Perspectives (1983)

The replica plating method as developed by Lederberg has been used to differentiate between "true" and "false" histidine-requiring revertant bacterial colonies which develop on minimal agar plates in the Ames test. Strains of S. typhimurium LT2, TA 100, when exposed to either sodium dichromate or the fumes from the welding of stainless steel, develop colonies whose apparent numbers are directly in proportion to the Cr(VI) content per plate in both cases, over a wide dose range. Replica impressions of the resulting colonies were transferred to Vogel Bonner minimal agar plates and incubated for 48 hr at 37 degrees C. It was then observed that considerable numbers of "false" revertant colonies were obtained at those Cr(VI) doses which resulted in a pronounced toxic effect, albeit with an acceptable level of the bacterial background lawn. No morphological distinction between "true" and "false" revertant colonies could be made. Although it would appear that at low doses (i.e., low toxicity) the true mutagenicity of stainless steel welding fumes can be completely accounted for by the presence of Cr(VI), the dose range over which the mutagenicity assay is reliable cannot be estimated from examination of the background lawn or from an estimate of the degree of survival of the treated cultures. Thus there is raised a serious question concerning the reliability of quantitative data published in bacterial mutagenicity testing where replica testing of the histidine requirement of the resulting "revertant" colonies is not routinely made. It is suggested that the replica technique can easily be developed as a simple and useful tool for the control of histidine requirement and ampicillin resistance in routine mutagenicity testing.(ABSTRACT TRUNCATED AT 250 WORDS)
Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease.
Authors: S H Murch, C P Braegger, J A Walker-Smith, T T MacDonald
Journal: Gut (1993)

This study determined the location and tissue density of cells immunoreactive for tumour necrosis factor alpha (TNF alpha) in intestinal specimens from 24 patients with chronic inflammatory bowel disease (15 with Crohn9s disease, nine with ulcerative colitis) and 11 controls. There was significantly increased density of TNF alpha immunoreactive cells in the lamina propria of both ulcerative colitis and Crohn9s disease specimens, although the distribution of these cells differed in the two conditions. In ulcerative colitis most of the TNF alpha immunoreactivity was seen in the subepithelial macrophages, with comparatively less in the deep lamina propria, while in Crohn9s disease immunoreactive cells were distributed evenly throughout the lamina propria. Increased submucosal immunoreactivity was found only in Crohn9s disease, in which TNF alpha positive macrophages tended to cluster around arterioles and venules, often infiltrating and disrupting vascular endothelium. It is suggested that this degree of TNF alpha production probably contributes significantly to the pathogenesis of both Crohn9s disease and ulcerative colitis, by impairing the integrity of epithelial and endothelial membranes, increasing inflammatory cell recruitment, and by prothrombotic effects on the vascular endothelium.
Blood lead and blood pressure: some implications for the situation in The Netherlands.
Authors: W L de Kort, W C Zwennis
Journal: Environmental Health Perspectives (1988)

Studies performed earlier have shown a positive relation between blood lead (a parameter for lead body burden) and blood pressure, whereas such a relation between urine cadmium (a parameter for cadmium body burden) and blood pressure could not be shown. Median (i.e., 50th percentile, P50) blood levels in the general population in the Netherlands are in the range of 80 to 150 micrograms/L. Persons occupationally exposed to lead show median blood lead levels that may exceed 400 micrograms/L. To study causality, a prospective study among lead workers is desired.
Reliability of cardiotocography in predicting baby's condition at birth.
Authors: P Curzen, J S Bekir, D G McLintock, M Patel
Journal: BMJ (1984)

A prospective study of 6825 labours was undertaken to determine the relation between the Apgar scores of the babies at one minute and the cardiotocograph tracing in labour. The sensitivity of an abnormal tracing was 35.2% for babies who needed intermittent positive pressure ventilation and 20.0% for babies who did not but who had Apgar scores of less than 7. The sensitivity of an abnormal tracing for all babies with an Apgar score of less than 7 was 23.2%. The positive predictive value of an abnormal tracing was 8.7% for babies who needed intermittent positive pressure ventilation and 18.7% for babies who did not but who had an Apgar score of less than 7. The positive predictive value of an abnormal tracing was 27.4% for all babies with an Apgar score of less than 7. The specificity of the tracing was 93.4% for babies with an Apgar score of 7 or over. The relatively high incidence of false positive predictions might be explained on the grounds that abnormalities in the cardiotocograph tracing are a more sensitive indicator of hypoxia than the Apgar score. False negative predictions might have been due to adverse factors other than hypoxia--for example, fetal trauma, compression of the head, infection, and analgesia in labour. These findings suggest that the current overdependence on fetal monitoring by cardiotocography alone should be examined and that other reliable indicators for non-hypoxic fetal distress should be sought.
Papillary Muscle Hypertrophy Appreciated on MUGA
Authors: Kevin E. Schlegel, Yang-En Kao, Sun Y. Kim
Journal: Clinical Nuclear Medicine (2009)

Multiple gated cardiac blood pool ventriculography was performed on a 53-year-old man with multiple myeloma. The left ventricular ejection fraction was normal but a small area of photon deficiency was present in the anterolateral left ventricular chamber. Cardiac MRI revealed slight thickening of the left ventricular myocardium and a hypertrophied papillary muscle.
Targeting human telomerase reverse transcriptase with recombinant lentivector is highly effective to stimulate antitumor CD8 T-cell immunity in vivo
Authors: Olivier Adotévi, Karine Mollier, Christine Neuveut, Magalie Dosset, Patrice Ravel, Wolf-Hervé Fridman, Eric Tartour, Pierre Charneau, Simon Wain-Hobson, Pierre Langlade-Demoyen
Journal: Blood (2010)
Physical activity to prevent obesity in young children
Authors: John J Reilly, James Y Paton, J H McColl, A Williamson
Journal: BMJ (2006)

Physical activity to prevent obesity in young children Negative outcome or protocol problem?Editor-Although the article by Reilly et al on physical activity to prevent obesity in young children emphasises that adherence to protocol was good, 1 an interview with Reilly on the Today programme (7.20 am, 6 October 2006) cited the difficulty in getting children to increase their activity as much as required-that is, not a negative outcome, but a problem in achieving sufficient increase to make the intervention effective.Which was the case?
Predictive model to assess risk for cardiac allograft vasculopathy: An intravascular ultrasound study
Authors: Mandeep R. Mehra, Hector O. Ventura, Richard Chambers, Tyrone J. Collins, Stephen R. Ramee, Marc A. Kates, Frank W. Smart, Dwight D. Stapleton
Journal: Journal of the American College of Cardiology (1995)
Can islet cell transplantation treat diabetes?
Authors: S. A White
Journal: BMJ (2000)

Type 1 diabetes mellitus is a major burden on patients and healthcare economies. The early identification of patients at risk of developing chronic complications would allow timely intervention thus reducing complications, improving the quality of life, prolonging life expectancy, and lowering the cost of treatment. The main determinant of developing chronic complications is prolonged exposure to hyperglycaemia.1 There is no doubt that intensive insulin regimens can reduce the onset and progression of complications from diabetes but they are non-physiological and have an increased risk of causing severe hypoglycaemia. They are also labour intensive and difficult for patients to implement.

The only way to restore long term euglycaemia is by transplanting a vascularised pancreas. This procedure has been performed in over 15 000 recipients worldwide and has an 85% rate of graft survival at one year— that is, these recipients remained insulin independent.2 During the past …
RESULTS OBTAINED IN THE TREATMENT OF ACNE BY EXPOSURE TO THE X-RAYS.
Authors: R. R. CAMPBELL
Journal: JAMA (1902)

Two effects produced by the<i>x</i>-rays, namely, the checking of pus formation and the atrophy produced in the follicles, suggested its use in the treatment of acne. The results obtained have been sufficiently gratifying, in my opinion, to justify the report of the following cases: <h3>Case 1.</h3> —Miss E. R., aged 20, had been under constitutional and local treatment for three months, without any appreciable improvement in the local condition. Early in January, 1902, the<i>x</i>-ray exposures were begun. She was given three exposures weekly of ten minutes each, with the tube 15 to 20 cm. distant. After two weeks there was manifest improvement and the exposures were reduced to two sittings weekly; by the end of February no active lesions or comedones could be detected, and the exposures were further reduced to once weekly until the end of March when all treatment was discontinued, and from that
Individual Genomes on the Horizon
Authors: Richard P. Lifton
Journal: New England Journal of Medicine (2010)

Physicians have long recognized that pinpointing specific causes of disease in individual patients enables therapies that are the most likely to confer benefit with the fewest adverse effects. We also recognize the potential for disease prevention through identification of specific risk factors and mitigation of their effects. For a century, we have known that many of these risk factors are genetic. In the past 20 years, the genomic revolution has translated this knowledge into a new understanding of disease: mutations that cause more than 2000 mendelian diseases have been identified, which has led to the rewriting of textbooks of pathophysiology . . .
Multidisciplinary approach aids successful swallowing
Authors: K. Simmons
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CURIOSITIES OF HOMŒOPATHIC PHARMACY.Read before the Medical Society of the District of Columbia, April 23, 1890.
Authors: ROBERT REYBURN
Journal: JAMA (1890)

Having recently obtained a copy of the circular and price list, issued by a dealer in higher potencies residing in New York City, I desire to impart to the members of this Society and the profession, some of the information therein contained. This document is a printed pamphlet of thirty-two pages, and is entitled "Catalogue of Morbific Products, Nosodes, and other Remedies in High Potencies." These remedies are for sale at No. 13 W. 38th St., New York City. By Samuel Swan, M.D. Glancing over the catalogue, on page 16, we were struck by one article of the materia medica, kept for sale and called "luna, or moonlight." How in the world is this obtained, and what are its properties? Astronomers have long disputed as to whether the rays of the moon possessed any heating power, but why need they any longer be in doubt, when they may be bought
Detailed assessments of childhood adversity enhance prediction of central obesity independent of gender, race, adult psychosocial risk and health behaviors
Authors: Cynthia R. Davis, Eric Dearing, Nicole Usher, Sarah Trifiletti, Lesya Zaichenko, Elizabeth Ollen, Mary T. Brinkoetter, Cindy Crowell-Doom, Kyoung Joung, Kyung Hee Park, Christos S. Mantzoros, Judith A. Crowell
Journal: Metabolism (2013)
Effects of Combined Ezetimibe and Simvastatin Therapy as Compared With Simvastatin Alone in Patients With Type 2 Diabetes: A Prospective Randomized Double-Blind Clinical Trial
Authors: Maria Sarigianni, Niki Katsiki, Dimitri P. Mikhailidis
Journal: Diabetes Care (2010)

Ruggenenti et al. (1) report the effect of adding ezetimibe to simvastatin in patients with type 2 diabetes. Some additional comments could be of interest.

The serum HDL cholesterol was significantly lower after adding …
Less-frequent warfarin dose assessment was noninferior for patients with stable INRs
Authors: Francesco Dentali
Journal: Annals of Internal Medicine (2012)

Source Citation Schulman S, Parpia S, Stewart C, et al. Warfarin dose assessment every 4 weeks versus every 12 weeks in patients with stable international normalized ratios: a randomized trial. Ann Intern Med. 2011;155:653-9. 22084331
New guidelines relax blood pressure goals
Authors: M. McCarthy
Journal: BMJ (2013)

In a major revision to treatment goals, an expert panel has concluded that older hypertensive patients, those aged 60 years or older, should be treated to a blood pressure target of less than 150/90 mm Hg, rather than 140/90 mm Hg as recommended in previous guidelines.1

The panel, the Eighth Joint National Committee, was made up of 17 experts initially convened by the US National Heart, Lung, Blood Institute (NHLBI) to update existing recommendations for the management of hypertension. The panel limited its evidence review to randomized controlled trials.

For younger patients, those 30 through 59 years of age, the panel recommended a diastolic treatment goal of under 90 mm Hg, but found there was insufficient evidence to set a goal for systolic blood pressure for patients younger than 60 years or for a diastolic goal for those …
CIN or Not to Sin
Authors: Cecilia M. Fenoglio
Journal: JAMA (1984)

Cervical neoplasia has been extensively studied with respect to its pathological and epidemiologic factors. There is a continuum of disease that ranges from cervical intraepithelial neoplasia (CIN)<sup>1</sup>to widespread metastatic disease. The risk factors for CIN or invasive cancers developing appear to be similar. The epidemiology of cervical neoplasia was first studied by Gagnon,<sup>2</sup>who showed that this disease was absent in a population of Canadian nuns. Since this initial study, it is clear that cervical cancer is related to a number of identifiable risk factors, including early sexual activity, multiple pregnancies, multiple sexual partners, early age at first pregnancy or first marriage, promiscuity, and exposure to a "high-risk" male sexual partner. When all of the epidemiologic risk factors are analyzed, one finds that they have in common the degree of sexual activity engaged in by the women with cervical neoplasia or by their sexual partner(s) and that
CARE AND OUTCOMES OF HISPANICS ADMITTED WITH HEART FAILURE WITH PRESERVED AND REDUCED EJECTION FRACTION: FINDINGS FROM GET WITH THE GUIDELINES-HEART FAILURE
Authors: Rey Percival VIvo, Selim R. Krim, Nassim R. Krim, Xin Zhao, Adrian F. Hernandez, Eric D. Peterson, Ileana L. Piña, Deepak L. Bhatt, Lee H. Schwamm, Gregg C. Fonarow
Journal: Journal of the American College of Cardiology (2011)
Left ventricular dimensions and autonomic balance during head-up tilt differ between patients with isoproterenol-dependent and isoproterenol-independent neurally mediated syncope
Authors: Koichi Mizumaki, Akira Fujiki, Masanao Tani, Mayumi Shimono, Hideki Hayashi, Hiroshi Inoue
Journal: Journal of the American College of Cardiology (1995)
Identification of Gulf War Syndrome: Methodological Issues and Medical Illnesses
Authors: Pamela Kaires
Journal: JAMA (1997)

<h3>To the Editor.</h3> —After reading the articles by Dr Haley et al<sup>1-3</sup>on Gulf War illness, I would fault the opinions of the Presidential Advisory Committee on Gulf War Veterans' Illnesses<sup>4</sup>and Dr Landrigan<sup>5</sup>for downplaying the neuropsychological findings and highlighting stress-related factors. If this information was known in September 1995, it is disturbing that 1 conclusion of the Presidential Advisory Committee was not to expand detailed neuropsychological studies for veterans with cognitive complaints as standard assessment despite the increased cost of the evaluation. It is also disturbing that the second conclusion highlighted was not to expand the studies on the effects of the combination of<i>N</i>,<i>N</i>-diethyl-<i>m</i>-toluamide (DEET) and pyridostigmine bromide as well as sarin.
Many trusts fail to monitor whether complaints have any effect, says watchdog
Authors: Zosia Kmietowicz
Journal: BMJ (2007)

NHS trusts in England are failing to act on and learn from the complaints they get, says the national healthcare watchdog.

Results from the Healthcare Commission's first ever audit of complaint handling in the NHS show that the way in which complaints are followed up varies greatly.

The commission identified the 10% of trusts that were most at risk of not meeting the core standard set down by the government on handling complaints. These 32 trusts, together with 10 others selected because they handled complaints well, were inspected by the commission in February and March this year.

The core standard requires trusts to make complaints procedures accessible, to act on concerns and make changes where appropriate, …
Bovine lactoferrin potently inhibits liver mitochondrial 8-OHdG levels and retrieves hepatic OGG1 activities in Long-Evans Cinnamon rats
Authors: Akihito Tsubota, Tetsuya Yoshikawa, Koichi Nariai, Makoto Mitsunaga, Yoko Yumoto, Keiko Fukushima, Sadayori Hoshina, Kiyotaka Fujise
Journal: Journal of Hepatology (2008)
Introductory Address on the Progress of the Owens College
Authors: A. Gamgee
Journal: BMJ (1883)

tend a rookery, or join the fungus-eaters-nay, you may grow auri- culas and carnations in a box even in the back street of a town, and their silent dainty ways and lovely faces will make you forget to write that sharp letter you intended for your medical brother.You will go instead to read a chapter of the adventures of Uncle Toby and Corporal Trim, of their gentle souls and of their hobby-horse, and so grow into peace with all men.My lear friends, my very dear colleagues with whom I have marched for nearly a quarter of a century, my less dear but most welcome younger friends, with whom I join hands first to-day, I