tbuckley/cabot-search huggingface dataset:
A Study of the Attitude of Japanese Families of Schizophrenics Toward their Ill Members
Authors: Y. Sakamoto
Journal: Psychotherapy and Psychosomatics (1969)

Research Articles| February 12 2010 A Study of the Attitude of Japanese Families of Schizophrenics Toward their Ill Members Subject Area: Psychiatry and Psychology Y. Sakamoto Y. Sakamoto Sakamoto Hospital, Higashiosaka Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1969) 17 (5-6): 365–374. https://doi.org/10.1159/000286051 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Y. Sakamoto; A Study of the Attitude of Japanese Families of Schizophrenics Toward their Ill Members. Psychother Psychosom 31 December 1969; 17 (5-6): 365–374. https://doi.org/10.1159/000286051 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1969Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Abstract 4682: Recurrence risk factors for advanced gastric cancer after D2 gastrectomy followed by adjuvant chemotherapy
Authors: Jun-Eul Hwang, Min-Jee Kim, Hyun-Jeong Shim, Woo-Kyun Bae, Sang-Hee Cho, Ik-Joo Chung
Journal: Cancer Research (2014)

Abstract Background Recent trials demonstrated that the adjuvant chemotherapy for stage II or III gastric cancer after curative D2 gastrectomy is effective for preventing recurrence. The objective of this study was to clarify the risk factors for recurrence in patients who received adjuvant chemotherapy after curative D2 gastrectomy. Materials and methods We retrospectively analyzed the factors predicting recurrence in 206 patients with stage II or III gastric cancer who received oral S-1 or 5-FU and cisplatin (FP) chemotherapy following curative D2 gastrectomy between April 2004 and December 2011. Results The median follow-up time after surgery was 2.93 years. A total of 136 patients received FP chemotherapy, and 70 patients received S-1. 3 year recurrence-free survival was 66.7%. In univariate analysis, gastroesophageal junction cancer, stage III, T3/T4 tumor, N2/N3 nodal status, and presence of both lymphovascular invasion (LVI) and perineural invasion (PNI) were associated with shorter recurrence-free survival. Moreover, Multivariate analysis showed male (HR 1.909; 95% CI 1.067-3.417; p=0.029), stage III (HR 3.884; 95% CI 1.741-8.662; p=0.001), and presence of both LVI and PNI (HR 2.293; 95% CI 1.367-3.846; p=0.002) were independent risk factors for recurrence. Conclusion Presence of both LVI and PNI is a strong recurrence risk factor for patients with stage II and stage III R0 resected gastric cancer who received adjuvant chemotherapy. Citation Format: Jun-Eul Hwang, Min-Jee Kim, Hyun-Jeong Shim, Woo-Kyun Bae, Sang-Hee Cho, Ik-Joo Chung. Recurrence risk factors for advanced gastric cancer after D2 gastrectomy followed by adjuvant chemotherapy. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4682. doi:10.1158/1538-7445.AM2014-4682
Insights into thymic purine metabolism and adenosine deaminase deficiency revealed by transgenic mice overexpressing ecto-5'-nucleotidase (CD73).
Authors: R Resta, S W Hooker, A B Laurent, S M Jamshedur Rahman, M Franklin, T B Knudsen, N L Nadon, L F Thompson
Journal: Journal of Clinical Investigation (1997)

The adenosine producing enzyme ecto-5'-nucleotidase (5'-NT) is not normally expressed during thymocyte development until the medullary stage. To determine whether earlier expression would lead to adenosine accumulation and/or be deleterious for thymocyte maturation, thymic purine metabolism, and T cell differentiation were studied in lckNT transgenic mice overexpressing 5'-NT in cortical thymocytes under the control of the lck proximal promoter. In spite of a 100-fold elevation in thymic 5'-NT activity, transgenic adenosine levels were unchanged and T cell immunity was normal. Inosine, the product of adenosine deamination, was elevated more than twofold, however, indicating that adenosine deaminase (ADA) can prevent the accumulation of adenosine, even with a dramatic increase in 5'-NT activity, and demonstrating the availability of 5'-NT substrates in the thymus for the first time. Thymic adenosine concentrations of mice treated with the ADA inhibitor 2'-deoxycoformycin (dCF) were elevated over 30-fold, suggesting that high ADA activity, rather than an absence of 5'-NT, is mainly responsible for low thymic adenosine levels. The adenosine concentrations in dCF-treated mice are sufficient to cause adenosine receptor-mediated thymocyte apoptosis in vitro, suggesting that adenosine accumulation could play a role in ADA-deficient severe combined immunodeficiency.
Individualized Care, as Well as Intensive Care, May Reduce Morbidity Among Premature Infants
Authors: Jody W. Zylke
Journal: JAMA (1990)

A NEONATAL intensive care unit is nothing like a womb. But perhaps it should be. Some investigators wonder if the stress of such a noisy, bright environment is contributing to the morbidity of premature infants. Great strides have been made over the last decade in improving survival of low—birth-weight infants. For those infants who weigh 750 to 999 g, survival has increased from 50% to 82%; for those infants who weigh 500 to 750 g, survival has increased from 11% to 36%. And, with the recent licensing of surfactant, it is likely that these figures will continue to improve. <h3>What Price Survival?</h3> This good news is offset in part by concern about the health of the survivors. Studies of older "ex-premies" suggest that they have motor deficits, learning disorders, and behavioral and attention problems. In one study by Mary Bozynski, MD, a neonatologist at the University of Michigan, Ann Arbor,
Complement receptor 2/CD21− human naive B cells contain mostly autoreactive unresponsive clones
Authors: Isabelle Isnardi, Yen-Shing Ng, Laurence Menard, Greta Meyers, David Saadoun, Iva Srdanovic, Jonathan Samuels, Jessica Berman, Jane H. Buckner, Charlotte Cunningham-Rundles, Eric Meffre
Journal: Blood (2010)
The Danger of Cocaine
Authors: William Pollin
Journal: JAMA (1985)

Cocaine's great danger has not as yet been adequately recognized, either by the general public or by most physicians. Historically, the price of cocaine has served as a barrier to widespread use. Recently, however, there has been a substantial increase in acreage devoted to the growth of the coca bush, from which cocaine is derived. The consequent possibility of decreased prices and substantial increases in its use, as has already occurred in a number of South American countries, is therefore very real. Thus, it is essential that the widespread impression that the drug is comparatively benign be rapidly corrected. The article by Bozarth and Wise<sup>1</sup>in this issue shows that in rats given free access to heroin or cocaine, cocaine is three times as lethal to them as heroin. Their study showed that after one month, a remarkable 90% of animals with free access to cocaine were dead, compared
Fat babies are not healthy, says new report on preventing obesity
Authors: B. Roehr
Journal: BMJ (2011)

<h3>ABSTRACT</h3> <h3>Background</h3> Congenital heart disease (CHD) accounts for approximately 40% percent of deaths in United States (US) children with birth defects. Previous US data from 1999-2006 demonstrated an overall decrease in CHD mortality. The objective of our study was to assess current trends in US mortality related to CHD from infancy to adulthood over the last 19 years and determine differences by sex and race/ethnicity. <h3>Methods</h3> We conducted an analysis of death certificates from 1999-2017 to calculate annual CHD mortality by age at death, race/ethnicity, and sex. Population estimates used as denominators in mortality rate calculation for infants were based on National Center for Health Statistics live birth data. Mortality rates in individuals &gt;1 year of age utilized US Census Bureau bridged-race estimates as denominators for population estimates. We characterized temporal trends in all-cause mortality, mortality resulting directly due to and related to CHD by age, race/ethnicity, and sex using joinpoint regression. <h3>Results</h3> There were 47.7 million deaths with 1 in 814 deaths due to CHD (n=58,599). While all-cause mortality decreased 16.4% across all ages, mortality resulting from CHD declined 39.4% overall. The mean annual decrease in CHD mortality was 2.6%, with the largest decrease for those age &gt;65years. The age-adjusted mortality rate decreased from 1.37 to 0.83 per 100,000. Males had higher mortality due to CHD than females throughout the study, although both sexes declined at a similar rate (∼40% overall), with a 3-4% annual decrease between 1999 and 2009, followed by a slower annual decrease of 1.4% through 2017. Mortality resulting from CHD significantly declined among all race/ethnicities studied, although disparities in mortality persisted for non-Hispanic Blacks versus non-Hispanic Whites (mean annual decrease 2.3% versus 2.6%, respectively; age-adjusted mortality rate 1.67 to 1.05 versus 1.35 to 0.80 per 100,000, respectively). <h3>Conclusions</h3> While overall US mortality due to CHD has decreased over the last 19 years, disparities in mortality persist for males compared to females and for non-Hispanic Blacks compared to non-Hispanic Whites. Determining factors that contribute to these disparities such as access to quality care, timely diagnosis, and maintenance of insurance will be important moving into the next decade.
Association of left ventricular hypertrophy regression and heart rate reduction with determinants of myocardial oxygen consumption and cardiovascular events: The LIFE study
Authors: Richard B. Devereux, Kristian Wachtell, Eva Gerdts, Peter Aurup, Kurt Boman, Jonathan Edelman, Markku Nieminen, Vasillios Papademetriou, Ying Wan, Bjorn Dahlof, Stevo Julius
Journal: Journal of the American College of Cardiology (2003)
Surgical Repair of Ventricular Septal Rupture and Ventricular Aneurysm
Authors: George R. Daicoff
Journal: JAMA (1968)

A successful surgical repair of a ruptured ventricular septum and resection of a left-ventricular aneurysm secondary to myocardial infarction was performed on a 76-year-old man. A review of the literature reveals that eight other patients with ventricular septal rupture and ventricular aneurysm underwent surgical treatment. Longer survival and better results correlated somewhat with younger age, higher systemic cardiac output, higher pulmonary artery pressure, concomitant aneurysmectomy, and an interval of three months or more between septal rupture and its repair. However, notable exceptions to each situation exist. The data suggest that patients with these complications undergo surgical treatment when nonoperative treatment is no longer effective; otherwise, elective repair should be carried out three months after the rupture. In either case, concomitant aneurysmectomy is advised.
Re: Vinorelbine-Induced Pancreatitis: a Case Report
Authors: Markus Raderer, Gabriela Kornek, Werner Scheithauer
Journal: JNCI Journal of the National Cancer Institute (1998)

was between 35 mg/m 2 and 40 mg/m 2 , and seven treatment courses in four patients were accompanied by prolonged nausea and emesis. However, no pathologic laboratory findings suggestive of subclinical pancreatitis could be demonstrated in any of the 25 patients. Thus, vinorelbine-induced acute pancreatitis seems to be an unusual phenomenon. According to the findings of Tester et al.
Function of nerves of the heart
Authors: R. J. LINDEN
Journal: Cardiovascular Research (1972)

Journal Article Function of nerves of the heart Get access R. J. LINDEN R. J. LINDEN From the Cardiovascular Unit, University of Leeds, and the General Infirmary and Killingbeck Hospital, Leeds Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 6, Issue 6, November 1972, Pages 605–626, https://doi.org/10.1093/cvr/6.6.605 Published: 01 November 1972
215 IS FLOW-MEDIATED DILATATION (FMD) ASSESSMENT A RELIABLE MARKER OF ENDOTHELIAL DYSFUNCTION IN LIVER CIRRHOSIS?
Authors: M. Marcacci, M. Fiorni, A. Lattanzi, G. Venturelli, G. Roveri, C. Boni, F. Zappia, A. Pietrangelo, R. Rossi, P. Ventura
Journal: Journal of Hepatology (2013)
Coordination of mural elements and myofilaments during arteriolar constriction.
Authors: G E Sleek, B R Duling
Journal: Circulation Research (1986)

Arterioles undergo major morphological changes during vasoconstriction. We used transmission electron microscopy to study wall morphology in both dilated and constricted microvessels to understand the cellular basis of these changes. The relation between the orientation and density of myofilaments and the distribution of dense bodies was analyzed with respect to the level of microvessel tone. The data show a strong correlation between the degree of arteriolar constriction and both the orientation and density of myofilaments. In dilated arterioles, myofilament orientation was predominantly circumferential across the entire smooth muscle cell, averaging 84 +/- 2 degrees (SEM) relative to a radial reference line. In vessels constricted to 50% of their maximal diameter, myofilament orientation was dependent upon the location within the cell, being largely circumferential at the adventitial border (77 +/- 4 degrees) and shifting to a radial arrangement at the intimal border (36 +/- 5 degrees). The reorganization of myofilaments during constriction was associated with a decrease in myofilament density at the intimal-medial border of the smooth muscle cells. The decrease in myofilament density resulted from a selective withdrawal of myofilaments from periluminal areas where "ridges" had formed. Our observations suggest that an ordered distribution of membrane-associated dense bodies along the periluminal aspect of the smooth muscle cells is responsible for both the myofilament reorganization and ridge formation during vasoconstriction. Results of the present study are incorporated into a hypothetical model of arteriolar ultrastructure compatible with the mural reorganization observed during vasoconstriction.
A mighty mouse: building a better model of multiple sclerosis
Authors: Richard M. Ransohoff
Journal: Journal of Clinical Investigation (2006)

The 2 cardinal cell populations mediating adaptive immunity are T and B lymphocytes. These cells play important but poorly understood roles in the immunopathological demyelinating disease multiple sclerosis (MS) and in a widely used animal model of human MS known as EAE. In the current issue of the JCI, 2 research teams report their parallel studies of double-transgenic mice expressing T and B cell receptors that recognize the same myelin protein (see the related articles beginning on pages 2385 and 2393). More than half of the double-transgenic mice spontaneously developed autoimmune demyelination in their spinal cords and optic nerves, exhibiting pathologies reminiscent of human MS. The studies describe an important new model for MS research.
Clinical Essentials of Calcium and Skeletal Disorders
Authors: Felix O. Kolb
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes19 October 1999Clinical Essentials of Calcium and Skeletal DisordersFelix O. Kolb, MDFelix O. Kolb, MDUniversity of California School of Medicine, San Francisco, California. (Kolb)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-8-199910190-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Deftos LJ. 314 pages. Caddo, OK: Professional Communications; 1998. $19.95. ISBN 1884735398. Order phone 580-367-9989.Field of medicine: Metabolic bone diseases.Format: Softcover book.Audience: Practitioners and trainees who seek current information on the rapidly changing field of metabolic bone diseases, especially osteoporosis.Purpose: To provide an overview of calcium metabolism and metabolic bone disorders with information on diagnosis and treatment and an emphasis on hyperparathyroidism and osteoporosis.Content: Fourteen chapters are arranged in four parts: regulation of skeletal and calcium metabolism, diseases of calcium metabolism, major diseases of skeletal metabolism, and other diseases of skeletal and calcium metabolism. Summaries ... Author, Article, and Disclosure InformationAffiliations: University of California School of Medicine, San Francisco, California. (Kolb) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 October 1999Volume 131, Issue 8Page: 635KeywordsBoneBone and mineral metabolismCalciumForecastingHyperparathyroidismMetabolic disordersOsteoporosisParathyroidSoftware tools ePublished: 15 August 2000 Issue Published: 19 October 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
How frequently are predicted peptides actually recognized by CD8 cells?
Authors: Srividya Sundararaman, Ioana Moldovan, Oleg Targoni, Wenji Zhang, Paul V Lehmann
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Detection of antigen-specific CD8 cells relies on the use of peptides that can bind to HLA-Class I molecules. There is extensive knowledge on individual HLA-alleles’ peptide binding requirements and for many antigens immunogenic peptides have been defined. The 32 individual
Proposed Rule Restricting Sale of Tobacco Products to Children
Authors: Stuart L. Nightingale
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Metabolism of cholesteryl esters of rat very low density lipoproteins.
Authors: O Faergeman, R J Havel
Journal: Journal of Clinical Investigation (1975)

Rat very low density lipoproteins (d smaller than 1.006), biologically labeled in esterified and free cholesterol, were obtained form serum 6 h after intravenous injection of particulate (3-H) cholesterol. When injected into recipient animals, the esterified cholesterol was cleared form plasma with a half-life of 5 min. After 15 min, 71% of the injected esterified (3-H) cholesterol had been taken up by the liver, where it was rapidly hydrolyzed. After 60 min only 3.3% of the amount injected had been transferred, via lipoproteins of intermediate density, to the low density lipoproteins of plasma (d 1.019-1.063). Both uptake in the liver and transfer to low density lipoproteins occurred without change of distribution of 3-H in the various cholesteryl esters. 3-H appearing in esterified cholesterol of high density lipoproteins (d greater than 1.063) was derived from esterification, presumably by lecithin: cholesterol acyltransferase, of simultaneously injected free (3-H) cholesterol. Content of free (3-H) cholesterol in the very low density lipoproteins used for injection could be reduced substantially by incubation with erythrocytes. This procedure, however, increased the rate of clearance of the lipoproteins after injection into recipient rats. These studies show that hepatic removal is the major catabolic pathway for cholesteryl esters of rat very low density lipoproteins and that transfer to low density lipoproteins occurs to only a minor extent.
The lactase persistence genotype is associated with body mass index and dairy consumption in the D.E.S.I.R. study
Authors: Amel Lamri, Antoine Poli, Nathalie Emery, Naima Bellili, Gilberto Velho, Olivier Lantieri, Beverley Balkau, Michel Marre, Frédéric Fumeron
Journal: Metabolism (2013)
737 Initial results of a 14-day study of the hepatitis C virus inhibitor protease VX-950, in combination with peginterferon-alpha-2a
Authors: H.W. Reesink, N. Forestiere, C.J. Weegink, S. Zeuzem, L. McNair, S. Purdy, H.-M. Chu, P.L.M. Jansen
Journal: Journal of Hepatology (2006)