The Neonatal Lupus Syndrome, Autoantibodies, and Connective Tissue Disease
Authors: JOHN L. ABRUZZO
Journal: Annals of Internal Medicine (1983)

Editorials1 November 1983The Neonatal Lupus Syndrome, Autoantibodies, and Connective Tissue DiseaseJOHN L. ABRUZZO, M.D.JOHN L. ABRUZZO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-5-716 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFactors transferred across the placenta from mothers with lupus erythematosus or whose sera contain detectable antibody to the soluble tissue ribonucleoprotein antigen anti-Ro (SS-A) contribute to the development of lesions in the skin (1) and heart (2) of their babies. This phenomenon has been called the neonatal lupus syndrome. The maternal factors causing these lesions do not appear to persist in the infant; the active lesions are self limited. The skin lesions resolve with complete healing and clearance of the rash. In the heart the active lesion heals but leaves permanent sequelae. These sequelae include endomyocardial fibrosis or fibroelastosis that...References1. FRANCOWESTONPEEBLESFORSTATPHANUPHAK HWCSP. Autoantibodies directed against sicca syndrome antigens in the neonatal lupus syndrome. J Am Acad Dermatol. 1981;4:67-72. CrossrefMedlineGoogle Scholar2. SCOTTMADDISONTAYLORESSCHERSCOTTSKINNER JPPEOR. Connective-tissue disease, antibodies to ribonucleoprotein, and congenital heart block. N Engl J Med. 1983;309:209-12. CrossrefMedlineGoogle Scholar3. VETTERRASHKIND VW. Congenital complete heart block and connective-tissue disease [Editorial]. N Engl J Med. 1983;309:236-8. CrossrefMedlineGoogle Scholar4. LEEBIASARNETT LWF. Immunogenetics of the neonatal lupus syndrome. Ann Intern Med. 1983;99:592-6. LinkGoogle Scholar5. REINERTSONKLIPPELJOHNSONSTEINBERGDECKERMANN JJAAJD. B-lymphocyte alloantigens associated with systemic lupus erythematosus. N Engl J Med. 1978;299:515-8. CrossrefMedlineGoogle Scholar6. BELLMADDISON DP. Serologic subsets in systemic lupus erythematosus: an examination of autoantibodies in relationship to clinical features of disease and HLA antigens. Arthritis Rheum. 1980;23:1268-73. CrossrefMedlineGoogle Scholar7. SONTHEIMERMADDISONREICHLINJORDONSTASTNYGILLIAM RPMRPJ. Serologic and HLA associations in subacute cutaneous lupus erythematosus, a clinical subset of lupus erythematosus. Ann Intern Med. 1982;97:664-71. LinkGoogle Scholar8. SHARP G. Mixed connective tissue disease. Bull Rheum Dis. 1975;25:828-31. Google Scholar9. MADDISONMOGAVEROPROVOSTREICHLIN PHTM. The clinical significance of autoantibodies to a soluble cytoplasmic antigen in systemic lupus erythematosus and other connective tissue diseases. J Rheumatol. 1979;6:189-95. MedlineGoogle Scholar10. PENNERREICHLIN EM. Primary biliary cirrhosis associated with Sjögren's syndrome: evidence for circulating and tissue-deposited Ro/anti-Ro immune complexes. Arthritis Rheum. 1982;25:1250-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Jefferson Medical College Hospital of Thomas Jefferson University Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLong-term outcome of mothers of children with complete congenital heart blockCollagen Vascular Diseases of ChildhoodConnective Tissue Disease Antibodies and PregnancyPregnancy and the Rheumatic Diseases: The Connective Tissue DiseasesConnective Tissue Disease Antibodies and Pregnancy 1 November 1983Volume 99, Issue 5Page: 716-717KeywordsCardiovascular therapyConnective tissue diseasesFibrosisHeartInfantsLesionsLupus erythematosusPlacentaRashesRibonucleoprotein Issue Published: 1 November 1983 PDF DownloadLoading ...