tbuckley/cabot-search huggingface dataset:
Lysergic Acid Diethylamide (LSD) in the Treatment of Alcoholism: An Investigation of Its Effects on Drinking Behavior, Personality Structure, and Social Functioning
Authors: Charles Savage
Journal: JAMA (1968)

LSD is the only new treatment for alcoholism which has been introduced in recent years; on that basis the authors justify this latest volume on LSD therapy. It gives a very brief, yet scholarly review of the neurophysiological, behavioral, and psychological effects of LSD as well as proposed mechanisms of action, assesses previous therapeutic work with LSD, weighs it in the balance, and finds it wanting. It reports a study that attempts to correct the flaws in previous studies by using random assignment, double-blind technique, placebo and routine therapy controls, and careful, independent assessment with psychometric and interview techniques before, and 6 and 18 months after, treatment. The authors distinguish two types of LSD therapy—psycholytic, which uses many LSD interviews employing a psychoanalytic model to achieve the release of unconscious material, and psychedelic, which usually employs a single LSD session, embedded in a matrix of supportive psychotherapy. The authors employ
Refined bleeding estimates in adults starting anticoagulants
Authors: B. A. Steinberg
Journal: BMJ (2014)

New tools for a difficult job

Oral anticoagulation is prescribed for the treatment and prevention of both venous thromboembolism and systemic embolism or stroke. Although treatment of acute events may require only short term use of anticoagulation, long term use is often prescribed, particularly for stroke prevention in patients with atrial fibrillation. The long term risk of bleeding associated with anticoagulation becomes a major consideration in decisions about treatment. While newer anticoagulants are associated with a lower risk of intracranial bleeding,1 ongoing or future risk of serious bleeding remains a contraindication to use of these agents.

Therefore, although guidelines on anticoagulation for patients with atrial fibrillation have been generally based on an objective assessment of stroke risk,2 3 they acknowledge that providers should also consider the patient’s risk of bleeding. Yet doctors have few objective tools that are broadly recommended. Unlike scores quantifying the risk of stroke, which were used to stratify patients in randomised trials of anticoagulation,1 4 no randomised study has tested the withholding of anticoagulation based on an increased risk of bleeding.

While several scores …
Israeli government puts squeeze on public hospitals
Authors: J. Siegel-Itzkovitch
Journal: BMJ (1994)

Israel's public hospitals, which have expanded steadily in recent years owing to increased demand from the local population and from hundreds of thousands of new immigrants are now being told to tighten their belts. The health ministry has said that it will set a 4-5% cap on the annual increase in money received from the public health funds (insurers). Each of the medical institutions will now have to negotiate a “global budget” with ministry officials instead of automatically receiving the standard daily rate for most inpatients and differential payments …
The Pervasive Presence of Fluctuating Oxygenation in Tumors
Authors: Laura I. Cárdenas-Navia, Daniel Mace, Rachel A. Richardson, David F. Wilson, Siqing Shan, Mark W. Dewhirst
Journal: Cancer Research (2008)

Abstract Tumor hypoxia is a persistent obstacle for traditional therapies in solid tumors. Strategies for mitigating the effects of hypoxic tumor cells have been developed under the assumption that chronically hypoxic tumor cells were the central cause of treatment resistance. In this study, we show that instabilities in tumor oxygenation are a prevalent characteristic of three tumor lines and previous characterization of tumor hypoxia as being primarily diffusion-limited does not accurately portray the tumor microenvironment. Phosphorescence lifetime imaging was used to measure fluctuations in vascular pO2 in rat fibrosarcomas, 9L gliomas, and R3230 mammary adenocarcinomas grown in dorsal skin-fold window chambers (n = 6 for each tumor type) and imaged every 2.5 minutes for a duration of 60 to 90 minutes. O2 delivery to tumors is constantly changing in all tumors, resulting in continuous reoxygenation events throughout the tumor. Vascular pO2 maps show significant spatial heterogeneity at each time point, as well as between time points. The fluctuations in oxygenation occur with a common periodicity within and between tumors, suggesting a common mechanism, but have tumor type–dependent spatial patterns. The widespread presence of fluctuations in tumor oxygenation has broad ranging implications for tumor progression, stress response, and signal transduction, which are altered by oxygenation/reoxygenation events. [Cancer Res 2008;68(14):5812–9]
Are Teaching Hospitals Worth the Extra Cost?
Authors: Arnold S. Relman
Journal: New England Journal of Medicine (1984)

Everyone knows that teaching hospitals have greater expenses and charge more for their services than do nonteaching hospitals. In 1981, for example, the average cost of care, per adjusted admission, in the more than 300 major teaching hospitals belonging to the Council of Teaching Hospitals was approximately twice that in the nonteaching hospitals.1 Several reasons are usually given for this striking difference. Teaching hospitals must bear the direct and indirect costs of their multiple teaching programs. They also do a certain amount of clinical research that is not fully reimbursed through outside grants and contracts. Their patients tend to be . . .
Quantitation of G0 and G1 phase cells in primary carcinomas. Antibody to M1 subunit of ribonucleotide reductase shows G1 phase restriction point block.
Authors: D L Tay, P S Bhathal, R M Fox
Journal: Journal of Clinical Investigation (1991)

Human cancers have an apparent low growth fraction, the bulk of cells presumed to being out of cycle in a G0 quiescent state due to the inability in the past to distinguish G0 from G1 cells. The allosteric M1 subunit of ribonucleotide reductase (M1-RR) is constitutively expressed by cycling cells (i.e., G1, S, G2-M). It is acquired during transition from G0 to G1, lost during exit to G0 and thus distinguishes G0 from G1 cells. To estimate the proportion of G0 and G1 cells in primary human breast (n = 5) and colorectal (n = 12) adenocarcinomas, we used both analytical DNA flow cytometry (ADFC) and immunoperoxidase staining of sections with the monoclonal antibody to M1-RR (MAb M1-RR). ADFC of fresh tumors revealed a low percentage of cells in the S phase (4.0 +/- 3.4%) but immunoperoxidase staining for M1-RR revealed an unexpectedly high proportion of positive cells (52.4 +/- 12.7%) in the G1, S, G2-M phases indicating a high G1 content of primary human tumors. Thus, human cancers are blocked in transition in G1 and are not predominantly in a G0 or quiescent differentiated state. This block was interpreted to mean that human cancers are responding to putative regulatory events at a restriction point in the G1 phase, such as relative growth factor deficiency, density inhibition, antiproliferative cytokines, or gene products. Using flow cytometry for both DNA and M1-RR content we found that human colon cancer cell lines arrest in the G1 but not G0 phase upon serum deprivation or density inhibition. Similarly, human breast cancer cell lines are arrested in G1 but not G0 phase by medroxyprogesterone acetate (MPA) or tamoxifen exposure. These findings match our in situ observations, and support the concept of a restriction point block in primary human tumors.
Arguments for neuropathic pain in sensitive skin
Authors: C. Saint-Martory, V. Sibaud, J. Theunis, V. Mengeaud, C. Lauzé, A.-M. Schmitt, L. Misery
Journal: British Journal of Dermatology (2014)

Journal Article Arguments for neuropathic pain in sensitive skin Get access C. Saint‐Martory, C. Saint‐Martory Department of Research, Exploration and Clinical Development Pierre Fabre Dermo‐Cosmétique Toulouse France Search for other works by this author on: Oxford Academic Google Scholar V. Sibaud, V. Sibaud Department of Research, Exploration and Clinical Development Pierre Fabre Dermo‐Cosmétique Toulouse France Search for other works by this author on: Oxford Academic Google Scholar J. Theunis, J. Theunis Department of Research, Exploration and Clinical Development Pierre Fabre Dermo‐Cosmétique Toulouse France Search for other works by this author on: Oxford Academic Google Scholar V. Mengeaud, V. Mengeaud Department of Research, Exploration and Clinical Development Pierre Fabre Dermo‐Cosmétique Toulouse France Search for other works by this author on: Oxford Academic Google Scholar C. Lauzé, C. Lauzé Department of Biometrics Pierre Fabre Laboratories Labège France Search for other works by this author on: Oxford Academic Google Scholar A.‐M. Schmitt, A.‐M. Schmitt Department of Research, Exploration and Clinical Development Pierre Fabre Dermo‐Cosmétique Toulouse France Search for other works by this author on: Oxford Academic Google Scholar L. Misery L. Misery Laboratory of Neurosciences of Brest University of Brest Brest FranceDepartment of Dermatology University Hospital of Brest Brest France Correspondence: Laurent Misery. E‐mail: laurent.misery@chu-brest.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 4, 1 April 2015, Pages 1120–1121, https://doi.org/10.1111/bjd.13466 Published: 01 April 2015
General Softening of the Medulla Spinalis
Authors: W. H. Madden
Journal: BMJ (1850)

According to the history I received, she had been subject for many years to frequent attacks of inflammation of the coats of the liver, but had not lately suffered from any acute affection of the kind.At the time of my visit, she complained of a dull, heavy pain in the right hypochon- drium and epigastrium, the parts being tender on pressure.There was no enlargement of the liver, nor any tenderness in any other part of the abdomen.She had no cough, and could draw a full breath without
Sex Differences and Genetic Associations With Myocardial Infarction
Authors: Christopher Newton-Cheh
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sleisenger &amp;amp; Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management
Authors: Diana L. Rowell
Journal: Annals of Internal Medicine (1998)

Medical Writings1 October 1998Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/ManagementDiana L. Rowell, MDDiana L. Rowell, MDOchsner Clinic, New Orleans, LouisianaAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-7-199810010-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management; 6th edition. Feldman M, Scharschmidt BF, Sleisenger MH; eds. 2046 pages. Philadelphia: WB Saunders; 1998. $195.00. ISBN 0721662919. Order phone 800-545-2522.Field of medicine: Gastroenterology and hepatology.Format: Hardcover book.Audience: Medical students, trainees, internists, and surgeons.Purpose: To serve as a comprehensive, authoritative text on the pathophysiology, diagnosis, and management of gastrointestinal and liver diseases.Content: This new edition incorporates significant changes. Most important, it contains 22 new chapters on the liver. A section on the approach to clinical problems includes good chapters on the problem-oriented evaluation of nausea and diarrhea ... Author, Article, and Disclosure InformationAffiliations: Ochsner Clinic, New Orleans, Louisiana PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1998Volume 129, Issue 7Page: 595KeywordsDrugsGastroenterology and hepatologyLiverLiver diseasesMolecular biologyNauseaNutritionPeptic ulcersSpontaneous bacterial peritonitisSurgeons Issue Published: 1 October 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Broader Organ Sharing
Authors: Joan Stephenson
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Present dangers and future threats: some perverse incentives in the NHS reforms
Authors: C. Paton
Journal: BMJ (1995)

The NHS reforms have come to mean all things to all men (and women). Identifying a market oriented purchaser-provider split as the conceptual heart of the reforms is still, however, useful. There are important perverse incentives in and around the NHS that are associated with the reforms; furthermore, many reactions to the resulting problems are paradoxical and often counterproductive. Hitherto most criticism of the reforms from the health policy and management community (as opposed to the professions and the public) has been tactical rather than fundamental. There are serious problems for the NHS associated both with the NHS market and with current, often tacit, strategies for the future of the service.
Age-related rheumatoid factors. Incidence and characteristics.
Authors: J Dequeker, R Van Noyen, J Vandepitte
Journal: Annals of the Rheumatic Diseases (1969)

The prevalence of the RA factor in sera of healthy young or middle-aged subjects has been found to be approximately 4 per cent.During the past few years, however, it has become increasingly clear that positive reactions are much more frequent when subjects 65 years of age and older are tested (Table I).Review of these studies reveals that the prevalence of positive reactions is consistently greater in aged than in young persons.There is considerable varia- tion among populations from different geographical areas and also according to the different techniques used in testing for the RA factor.The present work compares the prevalence of RA factor in the serum of a well-defined hospitalized population with that in a healthy ambulatory popu- lation and in a group of patients seen at a rheum- atology out-patients department; it also compares the results obtained with a Hyland RA slide test with and without inactivation of the serum, with a modification of this slide test (Watson, 1965) with a TABLE I INCIDENCE OF RA FACTOR IN ELDERLY PERSONS.SUMMARY OF THE LITERATURE Per cent.Positive reactions Auth3rs
TRYPSIN TREATMENT OF A CASE OF MALIGNANT DISEASE, INVOLVING THE LEFT TONSIL, BASE OF TONGUE AND EPIGLOTTIS.
Authors: JAMES T. CAMPBELL
Journal: JAMA (1907)

<h3>Patient and History.</h3> —J. H., aged 56, hotel clerk, of good family history; has had gonorrhea, but denies having had syphilis. On Sept. 1, 1905, the patient weighed 168 pounds, and about this time complained of pain over the left side of the face, which later became more manifest along the left lower jaw, in the ear, and from the occiput to the vertex. As the pain was unrelieved he had five left lower teeth and two back upper teeth extracted. He was treated at various hospitals and clinics until May 9, 1906, when I first saw him at the Post-Graduate Hospital. At that time he could not protrude his tongue and swallowed with much difficulty the smallest amount of liquid, impulsively placing his hand as though to support the lower jaw. His speech was thick and indistinct, he had left facial paralysis and complained of constant pain radiating over
Open access could reduce cost of scientific publishing
Authors: Susan Mayor
Journal: BMJ (2004)

Making scientific research available for free on the internet rather than through subscription journals could reduce the cost of publishing research by up to 30%, a report published this week says.

The report, Costs and Business Models in Scientific Research Publishing (available at www.wellcome.ac.uk/publications) indicates that an open access model of scientific publishing—where authors of a research paper pay for their research to be peer reviewed and made available on the web free of charge to readers—is economically viable.

It was based on a study by the Wellcome Trust, a research funding charity, that analysed the costs of publishing scientific, technical, and medical research articles by comparing two options: the “subscriber pays” model, in which readers pay for printed journals or online access, and the “author pays” model. Estimates of cost were based on discussions with senior staff across a range of journals …
Obtaining Informed Consent in Bangladesh
Authors: Niels Lynöe, Ziauddin Hyder, Mustaque Chowdhury, Lotta Ekström
Journal: New England Journal of Medicine (2001)

In the Clinical Problem-Solving article by Lurie et al. (Sept.7 issue), 1 the authors describe an 80-yearold man with unexplained back pain, an elevated erythrocyte sedimentation rate, plain films that showed only degenerative changes, and normal findings on neurologic evaluation.I believe magnetic resonance imaging (MRI) with gadolinium should have been performed before computed tomographic (CT) myelography was performed.CT myelography is invasive and expensive, and it does not provide nearly the range of diagnostic information provided by MRI.As the discussant stated, the differential diagnosis in this case included chronic infection, a metastatic tumor, vasculitis, and multiple myeloma.MRI with gadolinium could have led to the diagnosis of all these conditions except vasculitis, whereas CT myelography would not have been diagnostic of these disorders.
Studies on purified rheumatoid synovial collagenase in vitro and in vivo
Authors: Eugene A. Bauer, Arthur Z. Eisen, John J. Jeffrey
Journal: Journal of Clinical Investigation (1971)

Rheumatoid synovial collagenase obtained from culture medium can be separated by Sephadex gel filtration into two peaks of enzyme activity. These have been designated as fast-moving and slow-moving rheumatoid synovial collagenases on the basis of their electrophoretic mobility on polyacrylamide gels. The slow-moving rheumatoid synovial collagenase has been highly purified by affinity chromatography on collagen conjugated to Sepharose and used to prepare a monospecific anti-synovial collagenase antiserum. The antiserum against rheumatoid synovial collagenase has permitted the demonstration of immunoreactive collagenase in extracts of rheumatoid synovial tissue that have no detectable enzymatic activity. Collagenase has also been detected immunologically in enzymatically inactive culture medium from the first 24 hr of culture. Recovery of collagenase activity appears to be related to the chromatographic separation of the enzyme from serum antiproteases. The demonstration of collagenase in vivo in rheumatoid synovium adds further support for the concept that the enzyme is present in tissue at levels that are of significance in the pathogenesis of rheumatoid arthritis. In addition, rheumatoid synovial collagenase and human skin collagenase show complete immunologic identity when reacted with monospecific antiserum prepared against either of these purified enzymes, indicating that organ specificity between these two human collagenases is unlikely.
A STUDY IN ANESTHESIA.
Authors: ROSALIE M. LADOVA
Journal: JAMA (1900)

I submit a record of 101 cases of anesthesia administered by me during my service at the Woman's and Mary Thompson hospitals of Chicago. Notes were taken as to the duration, pulse and respiration range, condition of the pupils, gastric irritation, how soon anesthetized, how soon out, and the amount of anesthetic. The pulse and respiration were recorded every time there was a change in either of the two, and in a few cases a complete record was made. Space does not permit publication of the tables<i>in toto</i>, and so I give only the lowest and highest pulse and respiration, except that their complete range is given in a few cases. What attracts special attention in these tables is this pulse and respiration range, and the relation of the two under anesthesia. The normal ratio of the pulse and respiration is disturbed in almost every case, and the changes
Similar to adiponectin, serum levels of osteoprotegerin are associated with obesity in healthy subjects
Authors: David T. Ashley, Eoin P. O'Sullivan, Colin Davenport, Niamh Devlin, Rachel K. Crowley, Noel McCaffrey, Niall M. Moyna, Diarmuid Smith, Donal J. O'Gorman
Journal: Metabolism (2010)