tbuckley/cabot-search huggingface dataset:
WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus–truncated CXCR4
Authors: Toshinao Kawai, Uimook Choi, Lanise Cardwell, Suk See DeRavin, Nora Naumann, Narda L. Whiting-Theobald, Gilda F. Linton, Jaehyun Moon, Philip M. Murphy, Harry L. Malech
Journal: Blood (2006)
A 65-Year-Old Man With an Inguinal Hernia
Authors: George E. Wantz
Journal: JAMA (1997)

<h3>Dr DELBANCO:</h3> Mr K, a 65-year-old engineer and married father of 6, has had a moderate-sized hernia for many years and is trying to decide whether to have it repaired. Recently retired from his principal job but still working full-time, he is covered by Medicare and supplementary private insurance. He lives in a suburb of Boston, Mass, and for several years has been cared for by Dr M, a general internist practicing in a primary care unit at the Beth Israel Deaconess Medical Center. Mr K was born with a left-sided hernia. He recalls having episodes of pain as a young child and that he and his family attempted periodically to reduce the hernia. When he was 8 years old, the hernia was repaired. He has had no trouble on that side since. In 1961, he was first told of a hernia on the right side during a routine military
Contrast Media for Myelography-Reply
Authors: L. L. Wiltse
Journal: JAMA (1975)

<h3>In Reply.—</h3> The statement we made regarding diatrizoate and iothalamate was as follows: "Both diatrizoate and iothalamate have been used for myelography. Both are safe in certain prescribed conditions." Iothalamate meglumine (Conray 60) is being used extensively in many countries for myelography. When this material is used, it should not go above the conus. Thus, the patient has to be in a semisitting position. Convulsions do occur even with this precaution. I agree with Dr. Ranhosky that there is no place for diatrizoate (Hypaque 50) sodium in myelography and that it should not be used in the subarachnoid space under any circumstances.
Violent Death in a Metropolitan County
Authors: Norman B. Rushforth, Amasa B. Ford, Charles S. Hirsch, Nancy M. Rushforth, Lester Adelson
Journal: New England Journal of Medicine (1977)

Analysis of homicide patterns in Cuyahoga County, Ohio (metropolitan Cleveland), for 1958-1974 discloses the following major trends: a dramatic rise in overall homicide rates in the city (320 per cent) and suburbs (200 per cent); an increase in justifiable homicide; a doubling of the percentage of homicides incident to other felonies; a markedly increased incidence of homicide among younger persons; a conspicuous rise in firearm killings (now 81 per cent of all homicides); and a continued preponderance of intraracial homicide, with the highest rates among nonwhite males in the city. The trends in Cuyahoga County are consistent with those in other United States metropolitan counties. Homicide is responsible for a major part of the decreased life expectancy among young, urban, non-white men. The factor most consistently associated with these trends is the increased use of handguns.
Effect of Introduction of the Pneumococcal Conjugate Vaccine on Drug-Resistant<i>Streptococcus pneumoniae</i>
Authors: Moe H. Kyaw, Ruth Lynfield, William Schaffner, Allen S. Craig, James Hadler, Arthur Reingold, Ann R. Thomas, Lee H. Harrison, Nancy M. Bennett, Monica M. Farley, Richard R. Facklam, James H. Jorgensen, John Besser, Elizabeth R. Zell, Anne Schuchat, Cynthia G. Whitney
Journal: New England Journal of Medicine (2006)

Five of seven serotypes in the pneumococcal conjugate vaccine, introduced for infants in the United States in 2000, are responsible for most penicillin-resistant infections. We examined the effect of this vaccine on invasive disease caused by resistant strains.
Coronary Calcification
Authors: DOUGLAS A. EGGEN, JACK P. STRONG, HENRY C. MCGILL
Journal: Circulation (1965)

Measurements of the per cent of the surface with calcified lesions have been made for the three main coronary arteries from 1,242 consecutive necropsies of whites and Negroes between the ages of 30 to 69 years. Calcified lesions were most prevalent and most extensive in the left anterior descending branch and occurred with greatest frequency at 2 to 3 cm. from the orifice. Whites had greater involvement than Negroes and males had greater involvement than females. Prevalence and extent of calcification have been compared in four cause-of-death or disease categories; cases dying of coronary heart disease had greater involvement than the other three groups. The prevalence of ischemic myocardial lesions, complicated coronary lesions, or stenotic lesions was greater for cases with calcified lesions, and this prevalence increases with increase in extent of calcified lesions. The significance of the presence of coronary calcified lesions for the diagnosis of advanced coronary atherosclerosis is greatest for younger individuals.
Influence of dobutamine on regional myocardial blood flow and ventricular performance during acute and chronic myocardial ischemia in dogs.
Authors: J T Willerson, I Hutton, J T Watson, M R Platt, G H Templeton
Journal: Circulation (1976)

The data from this study document that dobutamine is a powerful inotropic agent in anesthetized dogs with acute myocardial ischemia and in awake, unsedated ones with chronic myocardial infarction. Dobutamine significantly increases heart rate at relatively small doses in anesthetized dogs with acute myocardial ischemia but considerably larger amounts of dobutamine are required to significantly increase heart rate in awake, unsedated dogs with myocardial infarction. Dobutamine also significantly increases regional myocardial blood flow to all areas of the heart at 20mug/kg/min in both anesthetized dogs with acute myocardial ischemia and awake, unsedated ones with myocardial infarction. However, in anesthetized dogs 20mug/kg/min of dobutamine significantly increases epicardial ST-segment elevation during acute myocardial ischemia. Propranolol prevents the inotropic and chronotropic effects of dobutamine in both anesthetized and awake, unsedated dogs. This study suggests that during experimental acute myocardial ischemia dobutamine given at doses that significantly increase heart rate and contractility may increase the extent of myocardial damage. The data also suggest that this agent should be of value in the setting of severe myocardial depression without associated severe coronary artery disease to increase cardiac contractility at doses that do not markedly alter heart rate. The hemodynamic and coronary blood flow effects of dobutamine in patients with and without severe coronary artery disease should be evaluated.
366 Combined hupa plus MMP-8 gene therapy reverts cirrhosis and improves hepatic encephalopaty
Authors: J ARMENDARIZBORUNDA, J GALVEZGASTELUM, A SEGURAFLORES, C BEASZARATE, A MIRANDA
Journal: Hepatology (2003)

Matrix metalloproteinases (MMPs) are a group of calcium- and zinc-dependent endopeptidases that are involved in maintaining the extracellular matrix. MMP-2 and MMP-9 are thought to be related to the disruption of the blood–brain-barrier (BBB) by their ability to cleave type IV collagen, the main component of the basal membrane. To establish the presence of MMP-2 and MMP-9 in the pathogenesis of canine cerebral leishmaniasis, we examined the levels of these metalloproteinases in the cerebrospinal fluid (CSF) and serum of dogs with visceral leishmaniasis and neurological symptoms (n = 16) and in the CSF and serum of uninfected healthy dogs (n = 10) using zymography. In the CSF of dogs with cerebral leishmaniasis there was a massive presence of active MMP-2, whereas only the levels of both proMMP-2 and proMMP-9 were elevated in the serum. Although the detected MMP activity in the CSF might merely be related to CNS inflammation, these enzymes may also play a collaborative role in the disease progression. Both MMP-2 and MMP-9 are known to target critical constituents of the BBB, and once activated, they may promote cerebral barrier breakdown, allowing the entrance of inflammatory cells and proteins within the nervous system milieu.
Advancing sports cardiology: blue sky thinking in Qatar
Authors: Bruce Hamilton, Mathew G Wilson, Hakim Chalabi
Journal: British Journal of Sports Medicine (2012)

Qatar, with its wide blue sky and searing desert sands, is not a location that clinicians and academics might immediately associate with cutting-edge sports cardiology. However, Aspetar Hospital is a very active unit, addressing key questions of both international and regional importance. As highlighted in this issue of BJSM , there are a large number of academic and clinical challenges within sports cardiology. The importance of sports cardiology in high-level competitive sport is incontrovertible; it is critical in preparticipation screening, management of ongoing cardiac conditions in athletes and event management guidelines to name but a few. In recognition of this significant role, European, North American and other international cardiology groups are increasingly dedicating personnel and funding to this field. These organisations deserve thanks for their insight and support in defining this specialty.

Several fundamental sports cardiology issues are yet to achieve consensus opinion – even among opinion leaders. Where does this leave the practising sports medicine physician who is at the ‘coalface’ of sports cardiology? They are all too aware of the complexity of unresolved issues relating to preparticipation cardiac …
P5-01-15: The Functional Role of the Estrogen-Regulated Gene GREB1: Characterization of a Novel GREB1 Knockout Mouse Model.
Authors: HJ Hnatyszyn, C Rodriguez, L Herbert, R Olson, ME Lippman
Journal: Cancer Research (2011)

Abstract Background: Gene regulated in breast cancer 1 (GREB1) was initially discovered in breast cancers as an estrogen-regulated gene that mediates estrogen-stimulated cell proliferation and is a candidate clinical marker for response to endocrine therapy. However, little is known of the functional role of GREB1 protein in normal breast tissue or breast cancers. Methods: To address this unknown role, our laboratory designed and created a novel Greb1 Knockout Mouse model (C57/bl MEL Greb1 KO). This constitutive model results in the loss of Greb1 mRNA and protein expression in cells where expression of Cre recombinase promotes the cleavage of exon 1 and intron 1 of the gene encoding Greb1. ROSA26 Cre C57/b1 MEL Greb1 KO mice heterozygous for the floxed Greb1 allele were crossed to generate experimental litters. Initial experiments were designed to evaluate if the complete loss of Greb1 expression in offspring homozygous for the floxed Greb1 allele was lethal during gestation. Experimental litters were tail clipped and genotyped using gDNA and genotype-specific PCR. Results: Offspring homozygous for the floxed Greb1 allele were identified in expected Mendelian ratios with wild type and heterozygous siblings. Loss of Greb1 expression was confirmed using RT-PCR, in situ hybridization and immunoblotting. Loss of both Greb1 alleles was not observed to be lethal during gestation for either male or female pups. Preliminary gross observation of these homozygous KO mice revealed no overt anatomical differences, however, they were 25–30% smaller than their heterozygous and wild-type siblings. Breeding experiments are underway to determine the fertility of crossbred Greb1 homozygous KO mice. Imaging experiments and necropsy with histochemical analysis of tissues will reveal any alteration in architecture and function. These findings will be summarized in this presentation. Discussion: As GREB1 has been identified as an estrogen-regulated gene involved in breast cancer cell proliferation and a potential target for new therapeutic strategies, it is important to understand the contribution of GREB1 to the differentiation, development and function of normal tissues as well as in breast cancers. Characterization of this novel Greb1 KO mouse model will provide answers to these functional questions surrounding GREB1. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P5-01-15.
THE EPIDEMIOLOGY OF ACUTE RESPIRATORY INFECTIONS CONDITIONED BY SULFONAMIDES.
Authors: L. A. JULIANELLE
Journal: Annals of Internal Medicine (1945)

Article1 January 1945THE EPIDEMIOLOGY OF ACUTE RESPIRATORY INFECTIONS CONDITIONED BY SULFONAMIDES.III. EFFECTS OF TREATMENT ON THE ORGANISM AND CARRIER OF DIPHTHERIA*L. A. JULIANELLE, MORRIS SIEGELL. A. JULIANELLESearch for more papers by this author, MORRIS SIEGELSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-1-21 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONDuring the course of observations on the changes in the bacterial flora of the upper respiratory passages associated with prolonged administration of sulfadiazine, the organism of diphtheria was unexpectedly isolated from the throats of two children receiving the drug. As will be recalled from the preceding reports in this investigation,1, 2a study was in progress on 60 children, half untreated in any way and the other half treated for 105 consecutive days with sulfadiazine. The purpose was to determine what effect this treatment might have on acute respiratory infection and in what way it might influence the organisms...Bibliography1. SIEGELJULIANELLE MLA: The epidemiology of acute respiratory infections conditioned by sulfonamides: I. General clinical considerations, Ann. Int. Med., 1945, xxii, 1-9. LinkGoogle Scholar2. JULIANELLESIEGEL LAM: The epidemiology of acute respiratory infections conditioned by sulfonamides: II. Gross alterations in the nasopharyngeal flora associated with treatment, Ann. Int. Med., 1945, xxii, 10-20. LinkGoogle Scholar3. MACCLEOD JW: The types mitis, intermedius and gravis of Corynebacterium diphtheriae. A review of observations during the past ten years, Bact. Rev., 1943, vii, 1-56. Google Scholar4. KOLMER JA: Failure of sulfonamide compounds in treatment of experimental B. diphtheriae (Corynebacterium diphtheriae) infections of guinea pigs, Proc. Soc. Exper. Biol. and Med., 1941, xlviii, 390-391. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication March 11, 1944.From the Division of Infectious Diseases, The Public Health Research Institute of The City of New York, Inc.Aided by a grant from the Metropolitan Life Insurance Company on the recommendation of the Influenza-Pneumonia Commission.†Died, August 12, 1944. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDie DiphtherieDie Diphtherie 1 January 1945Volume 22, Issue 1Page: 21-28KeywordsChildrenDrug administrationDrugsEpidemiologyInfectious diseasesPharynxPrevention, policy, and public healthRespiratory system proceduresSulfonamideUpper respiratory tract infections Issue Published: 1 January 1945 PDF DownloadLoading ...
Bortezomib enhances dendritic cell (DC)–mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications
Authors: Radek Spisek, Anna Charalambous, Amitabha Mazumder, David H. Vesole, Sundar Jagannath, Madhav V. Dhodapkar
Journal: Blood (2007)
HTLV-III antibodies in a remote population of eastern Zaire.
Authors: R H Gray, M J Wawer
Journal: BMJ (1985)

of community care, multidisciplinary evaluation of community based services-are very similar.Health professionals engaged in community care in India, if invited to Britain on a regular basis, can, I believe, meaningfully participate in both the theoretical and practical aspects of the planning and implementation of community care, often to mutual benefit.This would be true of health services in general, but especially so of community based mental health care.Such services as there are in India are negligible and there is a disappointing lack of professional skill in the area.
Using Physical Activity to Gain the Most Public Health Bang for the Buck
Authors: Todd M. Manini
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Vorinostat (NSC# 701852) in Patients with Relapsed Non-small Cell Lung Cancer: A Wisconsin Oncology Network Phase II Study
Authors: Anne M. Traynor, Sarita Dubey, Jens C. Eickhoff, Jill M. Kolesar, Kathleen Schell, Michael S. Huie, David L. Groteluschen, Sarah M. Marcotte, Courtney M. Hallahan, Hilary R. Weeks, George Wilding, Igor Espinoza-Delgado, Joan H. Schiller
Journal: Journal of Thoracic Oncology (2009)
Comparison of the absorption of two protein hydrolysates and their effects on water and electrolyte movements in the human jejunum.
Authors: P D Fairclough, J E Hegarty, D B Silk, M L Clark
Journal: Gut (1980)

Because of the generally more rapid amino acid absorption and lower osmotic pressure of small peptides compared with free amino acids, it has been suggested that 9elemental9 diets should contain both small peptides and free amino acids as the nitrogen source. While studying protein hydrolysates intended for use in such diets we observed surprising differences in the absorption of amino acids, water, and Na+ during jejunal perfusion of partial enzymic hydrolysates of two proteins (lactalbumin and fish) which contained high and approximately equal amounts of their constituent amino acids in the form of small peptides. Total alpha amino nitrogen (alpha NH2N) absorption from the lactalbumin hydrolysate was greater, and individual amino acid absorption more even, than from equinitrogenous solutions of the fish protein hydrolysate, or from mixture of free amino acids simulating either hydrolysate. Net water and Na+ absorption occurred during perfusion of the lactalbumin hydrolysate, whereas net water and Na+ secretion occurred during perfusion of the fish protein hydrolysate. These differences were significant (P &lt; 0.05 or less). As the differences between the hydrolysates are so marked, we conclude that it is unwise to assume that all protein hydrolysates are equally suitable for use in patients.
Narrative Research in Health and Illness
Authors: Christopher F C Jordens
Journal: BMJ (2005)

I s “narrative” a story, a drama, or a life? Is it a general class of text? According to this collection, narrative can be any of these things—and more. This raises an interesting question. Why do researchers focus on “narrative” when the meaning of the term is so ambiguous and variously interpreted? Eds Brian Hurwitz, Trisha Greenhalgh, Vieda Skultans Blackwell and BMJ Books,£45, pp 456 ISBN 0 7279 1792 7 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> The main motivation of this type of research seems to be to counter the social fragmentation that goes with specialisation. Specialisation creates communication barriers between experts and non-experts and also between different tribes of experts. Narrative bridges the … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
Antifibrotic Properties of Transarterial Oncolytic VSV Therapy for Hepatocellular Carcinoma in Rats With Thioacetamide-Induced Liver Fibrosis
Authors: Jennifer Altomonte, Sabrina Marozin, Enrico N De Toni, Antonia Rizzani, Irene Esposito, Katja Steiger, Annette Feuchtinger, Claus Hellerbrand, Roland M Schmid, Oliver Ebert
Journal: Molecular Therapy (2013)

Recombinant vesicular stomatitis virus (VSV) shows promise for the treatment of hepatocellular carcinoma (HCC), but its safety and efficacy when administered in a setting of hepatic fibrosis, which occurs in the majority of clinical cases, is unknown. We hypothesized that VSV could provide a novel benefit to the underlying fibrosis, due to its ability to replicate and cause cell death specifically in activated hepatic stellate cells. In addition to the ability of VSV to produce a significant oncolytic response in HCC-bearing rats in the background of thioacetamide-induced hepatic fibrosis without signs of hepatotoxicity, we observed a significant downgrading of fibrosis stage, a decrease in collagen content in the liver, and modulation of gene expression in favor of fibrotic regression. Together, this work suggests that VSV is not only safe and effective for the treatment of HCC with underlying fibrosis, but it could potentially be developed for clinical application as a novel antifibrotic agent.
Histologic Studies of Severe Delta Agent Infection in Venezuelan Indians
Authors: Hans Popper, Swan N. Thung, Michael A. Gerber, Stephen C. Hadler, Mario De Monzon, Antonio Ponzetto, Elias Anzola, Dalia Rivera, Alejandro Mondolfi, Ana Bracho, Donald P. Francis, John L. Gerin, James E. Maynard, Robert H. Purcell
Journal: Hepatology (1983)

To supplement a detailed epidemiologic study of an outbreak of viral hepatitis in Venezuelan Indians in isolated valleys, apparently resulting from delta agent infection, 10 autopsy specimens were studied histologically and immunocytochemically, and five biopsy specimens were examined. The patients were children and young adults and predominantly males. A sequence of hepatitis from focal necrosis with conspicuous small-droplet steatosis, through massive necrosis, prolonged postnecrotic collapse to early cirrhosis with massive collapse was postulated. The histologic changes tentatively suggest a cytopathic effect of the delta agent without significant indication of lymphocytotoxicity, at least in the parenchyma. Delta agent was demonstrated in hepatocyte nuclei in moderate amounts in the focal-necrotic stage and in isolated cells in the massive-necrotic stage, but in large amounts during the transition to cirrhosis. Whether these patients, in whom neither HBcAg nor HBsAg were demonstrable in the liver, suffered exclusively from superinfection of hepatitis B virus carriers and/or coinfection of hepatitis B virus with the delta agent remains to be resolved. Delta infection may occur in isolated settings with no relation to Italian origin, drug addiction, or polytransfusion. The infection is far more widely spread than previously assumed.
THE EFFECTS OF SQUALENE ON THE INCORPORATION OF ACETATE INTO PLASMA CHOLESTEROL IN MAN 1
Authors: J. S. McGuire, S. R. Lipsky
Journal: Journal of Clinical Investigation (1955)

Squalene is an unsaturated C30 H50 hydrocarbon found in the liver of the basking shark, and in human sebum and skin.Its relationship to cholesterol metabolism was first noted by Channon (1), who, in 1926, observed an increase in the cholesterol content of the livers of rats maintained on a squalene diet.Simultaneously, Heilbron, Kamm, and Owens (2), while studying the structure of this material, postulated that squalene might be an intermediate in the biosynthesis of cholesterol.More recently, with the aid of radioisotopes, Srere (3) demonstrated a significant decrease in the conversion of C"4-acetate