tbuckley/cabot-search huggingface dataset:
Myocardial blood flow response to isometric (handgrip) and treadmill exercise in coronary artery disease.
Authors: D K Lowe, D A Rothbaum, P L McHenry, B C Corya, S B Knoebel
Journal: Circulation (1975)

Thirty patients undergoing coronary cineangiography for diagnosis or evaluation of coronary artery disease had myocardial blood flow studies pre and post handgrip (isometric) exercise just prior to cineangiography. The handgrip was maintained at one-third maximum effort for three minutes. The patients also had treadmill exercise testing a day or two prior to the study. Treadmill testing was carried out until angina or positive ST-segment changes occurred or the patient attained 90% of predicted maximal heart rate. Of the 30 patients, seven had no coronary artery disease and 23 had significant disease, i.e., greater than 75% occlusion of at least one major coronary artery. Six of the 23 patients (26%) with disease had angina with handgrip and demonstrated a decreased myocardial blood flow, a significantly different response from the patients without agina (P less than 0.001). For the group without angina, the blood flow response was not significantly different from the normal group. Treadmill tests were positive in 19 of the 23 patients with coronary disease (83%). The arterial systolic and diastolic pressure rise was almost identical with the two stresses. The heart rate response, however, was significantly different (P less than 0.001), the rate increase being greater with treadmill exercise. The myocardial blood flow data demonstrate the relative insensitivity of handgrip exercise for the diagnosis of coronary artery disease. In terms of the supply demand ratio (diastolic pressure time/systolic pressure time) concept for subendocardial perfusion, it is possible that the difference between handgrip and treadmill stress may be due to the different heart rate response, more rapid heart rates having a relatively greater effect on diastolic than on systolic time indices, all other factors being equal.
Psychiatric Care of Burn Patients during Wartime
Authors: Jacob Avni
Journal: Psychotherapy and Psychosomatics (1975)

The psychiatric problems of burn patients during hospitalization and after discharge are reviewed. These are compared with the psychiatric problems encountered in burned Israeli soldiers during the last Middle East war (1973). Special conditions and characteristics of the work done by the psychiatric team in a plastic surgery department among the wounded, their relatives and the staff, are presented.
NONROTATION OF THE STOMACH SIMULATING SPONTANEOUS HYDROPNEUMOTHORAX
Authors: LOUIS I. HARRIS
Journal: JAMA (1927)

Although heterotaxia or transposition of the viscera has been known since 1643, when Petrus Severimus 1 reported one of the earliest authentic cases, failure of rotation of the stomach, which Nau prefers to designate as incomplete embryonic diaphragmatic hernia, is very exceptional. In the latter type of case the stomach is situated above the liver.  Several excellent contributions have been made on the subject of heterotaxia. Gruber, 2 in 1865, collected seventy-nine instances, and Kuchenmeister, 3 in 1893, increased the number of known cases to 149. Price, 4 in 1895, reported 190 cases from the literature, and Arneille 5 brought up the total to 254 in 1902. With the advent of the roentgen ray, the number of authentic instances of transposition of the viscera has grown prodigiously.  On the other hand, there is a great paucity in the report of cases of nonrotation of the stomach. Poillard, 6 in 1903,
TRFK-5 Reverses Established Airway Eosinophilia But Not Established Hyperresponsiveness in a Murine Model of Chronic Asthma
Authors: MUDIT MATHUR, KARIN HERRMANN, XIANTANG LI, YIMIN QIN, JOEL WEINSTOCK, DAVID ELLIOTT, JOSEPH MONAHAN, PHILIP PADRID
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

We studied the effects of an anti-interleukin (IL)-5 monoclonal antibody (TRFK-5) or dexamethasone (DEX) to reverse already established airway hyperresponsiveness (AHR) and tissue eosinophilia in a Schistosoma mansoni antigen-sensitized and airway-challenged mouse model of chronic asthma. In this model at 4 d after antigen challenge there is dramatic bronchoalveolar lavage fluid (BAL) eosinophilia, AHR to intravenous methacholine (MCh), and histologic evidence of peribronchial eosinophilic infiltration and mucoid cell hyperplasia. These changes persist for up to 2 wk after antigen challenge. Treatment with DEX from Days 4 through 10 significantly reduced established airway eosinophilia compared with animals sham-treated with saline from Days 4 –10 (120 ± 29 eosinophils/ μ l BAL for DEX-treated mice versus 382 ± 60 eosinophils/ μ l BAL for sham-treated animals, p < 0.01). DEX-treated mice also had dramatically reduced mucoid cell hyperplasia, and airway responsiveness returned to normal. In contrast, TRFK-5 given during the same time period reduced airway eosinophilia (86 ± 32 eosinophils/ μ l BAL versus 382 ± 60 eosinophils/ μ l BAL, p < 0.01) but did not reduce goblet cell hyperplasia or reverse already established AHR. Treatment with DEX but not TRFK-5 also inhibited interferon gamma (IFN- γ ) content of BAL fluid (0.49 ± 0.09 ng/ml BAL fluid for DEX versus 1.50 ± 0.24 ng/ml BAL fluid and 1.36 ± 0.13 ng/ml BAL fluid for TRFK-5 and sham-treated mice, respectively, both p < 0.001 versus DEX). Thus, treatment with DEX reduces established eosinophilic airway inflammation and AHR in S. mansoni–sensitized and airway-challenged mice but treatment with TRFK-5 reversed established eosinophilia without ameliorating established AHR. Together, these data suggest that once airway inflammation develops, neutralizing the effects of IL-5 or reducing eosinophilia alone may not result in inhibiting established AHR in atopic asthma.
Twenty four hour care in inner cities.
Authors: A. Livingstone, T. Jewell, J. Robson
Journal: BMJ (1989)

during the first vear.TFhe ouitpatient waiting time stands at two weeks, and sincc it opened the waiting time at the longer established unit has declined steadilI to an average of three months.We believe that providing adequate facilities of this type is a much more satisfactory solution to the problem of delays in fitting hearing aids than the proposal suggested in the Royal National Institute for the Deaf document entitled Hearing Aids -The Case for Change.
Cost of Detecting Malignant Lesions by Endoscopy in 2741 Primary Care Dyspeptic Patients Without Alarm Symptoms
Authors: Nimish Vakil, Nicholas Talley, Sander Veldhuyzen van Zanten, Nigel Flook, Tore Persson, Ewa Björck, Tore Lind, Elisabeth Bolling–Sternevald
Journal: Clinical Gastroenterology and Hepatology (2009)
B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues.
Authors: D A Frank, S Mahajan, J Ritz
Journal: Journal of Clinical Investigation (1997)

To explore the pathogenesis of chronic lymphocytic leukemia (CLL), we examined whether phosphorylation of one or more signal transducer and activator of transcription (STAT) factors was abnormal in cells from CLL patients. No constitutive tyrosine phosphorylation was detected on any STAT in CLL cells. To assess the phosphorylation of serine residues of STAT1 and STAT3 in CLL cells, we raised antibodies that specifically recognize the form of STAT1 phosphorylated on ser-727 and the form of STAT3 phosphorylated on ser-727. We found that in 100% of patients with CLL (n = 32), STAT1 and STAT3 were constitutively phosphorylated on serine. This was in contrast to normal peripheral blood B lymphocytes or CD5+) B cells isolated from tonsils, in which this phosphorylation was absent. Serine phosphorylation of STAT1 and STAT3 was seen occasionally in other leukemias, but it was a universal finding only in CLL. The serine phosphorylation of these STATs was a continuous process, as incubation of CLL cells with the kinase inhibitor H7 led to the dephosphorylation of these serine residues. The STAT serine kinase in CLL cells has not been identified, and appears to be neither mitogen-activated protein kinase nor pp70(s6k). In summary, the constitutive serine phosphorylation of STAT1 and STAT3 is present in all CLL samples tested to date, although the physiologic significance of this modification remains to be determined.
Guidelines Seek to Standardize Care for Diseased Heart Valves
Authors: Mike Mitka
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clues to the Bedside Diagnosis of Mild Idiopathic Subaortic Stenosis
Authors: Richard Reeve
Journal: JAMA (1966)

THE CLINICAL and hemodynamic findings in patients with severe idiopathic hypertrophic subaortic stenosis (IHSS) are very well known, but occasionally are not recognized, and mild cases are easily missed. An increase in duration and intensity of the murmur with the Valsalva maneuver, found only in IHSS, has been helpful in identifying mild cases. 1 The absence of this finding, however, does not exclude the diagnosis of IHSS. The following brief case report suggests that the increase in intensity of the murmur may be more sensitive than pressure changes during the Valsalva maneuver in identifying mild cases of IHSS.  Report of a Case  This patient, a muscular 37-year-old man, had no family history of heart disease. A murmur was first heard during a high school physical examination and was thought to be functional. He participated actively in sports until the age of 33, when he had syncope following exercise. He has
Prolonged Remission of Disseminated Atypical Adenomatous Hyperplasia Under Gefitinib
Authors: Ugo Pastorino, Elisa Calabrò, Elena Tamborini, Alfonso Marchianò, Marta Orsenigo, Alessandra Fabbri, Gabriella Sozzi, Silvia Novello, Filippo De Marinis
Journal: Journal of Thoracic Oncology (2009)
Recognizing an Opinion
Authors: William D. Novelli, George C. Halvorson, John Santa
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PREVENTION OF TUBERCULOSIS.
Authors: JOHN B. HAMILTON
Journal: JAMA (1897)

<h3>Mr. President and Colleagues:</h3> I stand here today by appointment in the place of the late Dr. Jerome Cochran of Montgomery, Alabama, whose preëminence in the science of preventive medicine easily singled him out from among his fellows, as peculiarly fitted to deliver the annual oration in State Medicine. His vast erudition, extended experience, and long public service made him<i>facile princeps</i>in all matters relating to sanitary work. Few have spoken with better right, or with greater authority. This is not the proper place to pronounce the eulogy of Jerome Cochran; that was done in this hall yesterday, but the world knows of his life and his work. The laws of Alabama which furnish us today the best model for Medical Legislation in other States, were largely the handiwork of Dr. Cochran, and the medical profession of that State is under enduring obligations to his memory. It was my
SERIOUS COMPLICATIONS OF RUPTURED INTERVERTEBRAL DISKS
Authors: WALTER E. DANDY
Journal: JAMA (1942)

Ruptured intervertebral disks are now known to be exceedingly common; they are, in fact, among the most frequent lesions treated surgically. Over 95 per cent of them are in the lumbar region, where they explain the overwhelming percentage of recurring pains low in the back plus sciatica in one or both legs. With rare exceptions it is now possible to diagnose and localize those in the lumbar region without spinal injections of iodized oil, air or other contrast medium or even without a lumbar puncture.<sup>1</sup>Up to the present time the course in all reported cases of ruptured disk except our first 2 has run true to form and there were no serious complications. Three serious sequelae encountered during the past month emphasize the potential dangers of this simple lesion when the diagnosis and treatment are delayed. One of the disks ruptured was in the cervical, another in the
Overlapping sirolimus-eluting stents: Intravascular ultrasound analysis frok the SIRIUS trial
Authors: Yoshihiro Morino, Junya Ako, Yasuhiro Honda, Shinjo Sonoda, Mitsuyasu Terashima, Ali Hassan, David R. Holmes, David O. Williams, Tim A. Fischell, Emily Keim, Paul G. Yock, Martin B. Leon, Jeffrey W. Moses, Peter J. Fitzgerald
Journal: Journal of the American College of Cardiology (2003)
Abstract P3-14-04: Symptomatic DCIS is a risk factor for invasion and should be managed accordingly
Authors: N Dimopoulos, K Williams, CC Kirwan, R Johnson, M Howe, NJ Bundred
Journal: Cancer Research (2012)

Abstract Background: The National ABS Guidelines indicate axillary surgery is unwarranted in DCIS but should be offered to patients undergoing mastectomy. Up to 30% of pre-operatively diagnosed DCIS lesions harbour occult invasive cancers at mastectomy. Methods: To determine if DCIS mode of presentation, size (or other clinical factors such as Grade or HER2 status) predict invasion or nodal involvement, 380 patients undergoing surgery with a DCIS pre-operative (B5) diagnosis were studied. In total 162 patients underwent mastectomy +/− axillary staging for DCIS and 216 conservation surgery between 2008–2011 in one unit. HER2, oestrogen receptor (ER) and progesterone receptor (PR) expression within primary DCIS were established using immunohistochemistry. HER2 was scored 0 (absent) to 3 (maximum). Scores ≥2 were taken as positive if amplified on FISH testing. ER and PR scored positive if ≥5% of cells stained. Results: In total 216 had Breast Conservation and 162 Mastectomy with 127 undergoing sentinel lymph node biopsy (111) or subsequent axillary surgery (16). Of 162 patients undergoing mastectomy for DCIS, 121 (75%) underwent axillary staging, with 9 (7%) having involved nodes. Screening mammography detected 117 (72%) but 45 (28%) presented symptomatically with a breast mass. Median age at diagnosis was 57.8 years (range 29–94). Women less than 35 years of age had tumours sized greater than 4 cm in 72.3% compared to 59% in older women (p &amp;lt; 0.05). In total 50 (31%) women with DCIS had occult invasive disease, with an additional 9 (6%) having microinvasion. Young age (p 0.003), - symptomatic presentation (p &amp;lt; 0.001), presence of a palpable mass (p &amp;lt;0.001), ultrasound visibility (p &amp;lt;0.01) and Her2 negativity (p &amp;lt; 0.05) were associated with invasion, however size of DCIS, grade, oestrogen and progesterone receptor status were not. Sentinel node involvement was associated with symptomatic presentation (p = 0.03) and presence of a palpable mass (p = 0.04) but not DCIS size, grade, age or receptor status. Conclusion: Symptomatic DCIS presents more frequently with an occult invasive component and nodal invasion. In symptomatic DCIS presenting with a mass lesion. Ultrasound of the axilla and breasts should be a requisite preoperative assessment for all women. Moreover, sentinel node biopsy should be considered in patients with DCIS and a mass lesion. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P3-14-04.
Viral Hepatitis, Type B (MS-2 Strain)
Authors: Saul Krugman
Journal: JAMA (1971)

Viral hepatitis, type B (MS-2) was prevented by active and passive immunization. Active immunization was induced by inoculation of a boiled, inactivated preparation of a 1:10 dilution of MS-2 serum in distilled water; two inoculations at four-month intervals were more effective than one. However, one inoculation gave enough protection to prevent some cases and modify others.
Metabolic Changes Preceding Exercise-induced Bronchoconstriction
Authors: M. Silverman, S. D. Anderson, S. R. Walker
Journal: BMJ (1972)

Five asthmatics aged 25-30 were studied during bicycle ergometer and treadmill exercise. Metabolic and ventilatory changes during exercise were compared with the degree of bronchoconstriction which followed exercise. In all patients bronchoconstriction was greater after treadmill exercise. Contrary to previous suggestions, exercise-induced bronchoconstriction did not seem to be caused by lactic acidosis, increase in minute ventilation, acidaemia, hypocapnia, or change in arterial Po(2)
A hyaluronic acid–salmon calcitonin conjugate for the local treatment of osteoarthritis: Chondro-protective effect in a rabbit model of early OA
Authors: Anna Mero, Monica Campisi, Marta Favero, Carlo Barbera, Cynthia Secchieri, Jean M Dayer, Mary B Goldring, Steven R Goldring, Gianfranco Pasut
Journal: Journal of Controlled Release (2014)
How Well Does Radionuclide Dipyridamole Stress Testing Detect Three-Vessel Coronary Artery Disease and Ischemia in the Region Supplied by the Most Stenotic Vessel?
Authors: STEPHEN M. ZAACKS, AMJAD ALI, JOSEPH E. PARRILLO, JOHN T. BARRON
Journal: Clinical Nuclear Medicine (1999)

This study was done to evaluate the accuracy of radionuclide dipyridamole stress imaging to detect multivessel disease and ischemia in segments of myocardium supplied by the most stenotic vessel.A retrospective analysis of consecutive patients with known triple-vessel disease of at least 50% stenosis in each of the three major epicardial coronary arteries who had exercise (n=44) or dipyridamole (n=86) stress testing, or both, within 6 months of coronary angiography.The accuracy of dipyridamole stress testing to detect three-vessel disease was 52% and ischemia was detected in the region supplied by the most stenotic vessel in 67% of patients. The sensitivity and specificity rates of radionuclide imaging to detect ischemia in the region supplied by the vessel of tightest stenosis were 69% and 74% for the left anterior descending coronary artery (LAD), 61% and 78% for the right coronary artery (RCA), and 61% and 57% for the left circumflex coronary artery (LCX). Based on these values, in 39% of patients in whom the RCA or LCX was the most stenotic vessel and in 31% of patients in whom the LAD was the most stenotic vessel, perfusion defects were not present on their nuclear scans.These results have important implications for interventional cardiologists who perform angioplasty on the most stenotic vessel, because the regions supplied by these vessels may not be the most ischemic. Furthermore, dipyridamole stress imaging may significantly underestimate the number of patients with substantial three-vessel coronary artery disease when qualitative imaging is done.
Human Polynucleotide Kinase Participates in Repair of DNA Double-Strand Breaks by Nonhomologous End Joining but not Homologous Recombination
Authors: Feridoun Karimi-Busheri, Aghdass Rasouli-Nia, Joan Allalunis-Turner, Michael Weinfeld
Journal: Cancer Research (2007)

Abstract Human polynucleotide kinase (hPNK) is a bifunctional enzyme possessing a 5′-DNA kinase activity and a 3′-phosphatase activity. Studies based on cell extracts and purified proteins have indicated that hPNK can act on single-strand breaks and double-strand breaks (DSB) to restore the termini to the chemical form required for further action by DNA repair polymerases and ligases (i.e., 5′-phosphate and 3′-hydroxyl termini). These studies have revealed that hPNK can bind to XRCC4, and as a result, hPNK has been implicated as a participant in the nonhomologous end joining (NHEJ) pathway for DSB repair. We sought to confirm the role of hPNK in NHEJ in the cellular setting using a genetic approach. hPNK was stably down-regulated by RNA interference expression in M059K glioblastoma cells, which are NHEJ positive, and M059J cells, which are NHEJ deficient due to a lack of DNA-PK catalytic subunit (DNA-PKcs). Whereas depletion of hPNK significantly sensitized M059K cells to ionizing radiation, no additional sensitization was conferred to M059J cells, clearly implying that hPNK operates in the same DNA repair pathway as DNA-PKcs. On the other hand, depletion of hPNK did not increase the level of sister chromatid exchanges, indicating that hPNK is not involved in the homologous recombination DSB repair pathway. We also provide evidence that the action of hPNK in the repair of camptothecin-induced topoisomerase 1 “dead-end” complexes is independent of DNA-PKcs and that hPNK is not involved in the nucleotide excision repair pathway. [Cancer Res 2007;67(14):6619–25]
Diet and Drug Therapy for Hypertension
Authors: Gordon P. Guthrie
Journal: Annals of Internal Medicine (1983)

Dialogue Summaries1 May 1983Diet and Drug Therapy for HypertensionGordon P. Guthrie Jr., M.D.Gordon P. Guthrie Jr., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-5-881_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlterations in the composition of the diet that are either known to influence or suspected of influencing hypertension and its treatment were discussed. We considered the recommendations by national authorities for restriction of excessive dietary salt as a public health measure. Essential hypertension has been linked to the relatively high salt intakes of citizens of industrialized societies. However, specific recommendations about salt intake to the general population are not yet indicated due to the unproven nature of the dietary salt hypothesis, and the unpopularity of the effort to modify the diets of the majority for the unproven benefit of a... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Gordon P. GuthrieJr., M.D.Affiliations: University of Kentucky PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1983Volume 98, Issue 5_Part_2Page: 881-881KeywordsDietDrug therapyHypertensionPrevention, policy, and public healthSalts ePublished: 1 December 2008 Issue Published: 1 May 1983 Copyright & Permissions© 1983 American College of PhysiciansPDF downloadLoading ...