Higher Prevalence of HLA-B12 in Patients with IgA Nephropathy
Authors: Alan V. Richman, James J. Mahoney, Thomas J. Fuller
Journal: Annals of Internal Medicine (1979)

Brief Reports1 February 1979Higher Prevalence of HLA-B12 in Patients with IgA NephropathyALAN V. RICHMAN, M.D., JAMES J. MAHONEY, M.D., THOMAS J. FULLER, M.D.ALAN V. RICHMAN, M.D., JAMES J. MAHONEY, M.D., THOMAS J. FULLER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-2-201 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWith the advent of immunofluorescence and electron microscopy, classification of renal disease has become more complex and sophisticated. One clinicopathologic entity that has become well defined is IgA nephropathy (Berger's disease). Patients with this disorder usually manifest normal renal function, hematuria, and minimal proteinuria with a usually benign clinical course (1, 2), although at times the course may be progressive. The symptomatology is often exacerbated by upper respiratory infections. The pathologic hallmarks of the disease are mesangial deposits of IgA with or without other immunoglobulins and complement, and electron dense deposits in the mesangial and subendothelial areas (1, 2).Patients...References1. LOWANCE D, MULLINS J, and MCPHAUL J: Immunoglobulin A (IgA) associated glomerulonephritis. Kidney Int 3:167-176, 1973 CrossrefMedlineGoogle Scholar2. FINLAYSON G, ALEXANDER R, JUNCOS L, SCHLEIN E, TEAGUE P, WALDMAN R, and CADE R: Immunoglobulin A glomerulonephritis. A clinicopathologic study. Lab Invest 32:140-148, 1975 MedlineGoogle Scholar3. BERGER J, YANEVA H, NABARRA B, and BARBANEL C: Recurrence of mesangial deposition of IgA after renal transplantation. Kidney Int 7:232-241, 1975 CrossrefMedlineGoogle Scholar4. MITTAL K, MICKEY M, SINGAL D, and TERASAKI P: Serotyping for homotransplantation. XVIII. Refinement of microdroplet lymphocyte cytotoxicity test. Transplantation 6:913-927, 1968 CrossrefMedlineGoogle Scholar5. SVEJGAARD A, JERSILD C, STAUB NIELSEN L, and BODMER W: HL-A antigens and disease. Statistical and genetical considerations. Tissue Antigens 4:95-105, 1974 CrossrefMedlineGoogle Scholar6. NOEL L, DESCAMPS B, JUNGERS P, BACK J, BUSSON M, SUET C, HORS J, and DAUSSET J: HLA antigen in three types of glomerulonephritis. Clin Immunol Immunopathol 10:19-23, 1978 CrossrefMedlineGoogle Scholar7. BERTHOUX F, GAGNE A, SABATIER J, DUCRET F, LE PETIT J, MARCELLIN M, MERCIER B, and BRIZARD C: HLA-BW35 and mesangial IgA glomerulonephritis (letter). N Engl J Med 298:1034-1035, 1978 CrossrefMedlineGoogle Scholar8. BRETTLE R, PETERS D, and BATCHELOR J: Mesangial IgA glomerulonephritis and HLA antigens (letter). N Engl J Med 299:200, 1978 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALAN V. RICHMAN, M.D.; JAMES J. MAHONEY, M.D.; THOMAS J. FULLER, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRare case of ankylosing spondylitis complicated by IgA vasculitisElevation of serum IgA in spondyloarthropathies and IgA nephropathy and its pathogenic roleImmunogenetic aspects of primary IgA nephropathyThe Occurrence of IgA-Nephropathy in Patients With Diabetes Mellitus May Not Be Coincidental: A Report of Five CasesC4B Deficiency in Two Siblings With IgA NephropathyRetroviral gp70 antigen in spontaneous mesangial glomerulonephritis of ddY miceHLA Class II Histoglobulins Involvement in Mesangial IgA Glomerulonephritis (Berger's Disease)A major gene model for the familial aggregation of plasma IgA concentrationFAMILIAL IgA NEPHROPATHY: A STUDY OF RENAL DISEASE IN AN AUSTRALIAN ABORIGINAL FAMILYDo genetic factors play a role in Berger's disease?IgA synthesis by lymphocytes from patients with IgA nephropathy and their relativesSeronegative spondyloarthropathies and IgA glomerulonephritis: A report of four cases and a review of the literatureThe Nephritogenic Immune Response and Renal ImmunopathogenesisAn immunohistological study of IgA nephropathy and a report of its incidence in IrelandB and T cell abnormalities in patients with primary IgA nephropathyIncidence of IgA-related nephritides in American Indians in New MexicoFamilial IgA NephropathyUrogenital DiseasesComplement phenotypes in glomerulonephritis: Increased frequency of homozygous null C4 phenotypes in IgA nephropathy and Henoch-Schönlein purpuraHLA-A, -B and -DR antigens in IgA nephropathyIdiopathic IgA nephropathyMesangial IgA NephropathyThe associations of HLA and other genetic markers with glomerulonephritisRole of HLA in IgA nephropathyStrong association between IgA nephropathy and HLA-DR4 antigenHLA and Bw35. 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