Vitamin D Supplementation: A Word of Caution
Authors: Bernadette M. Marriott
Journal: Annals of Internal Medicine (1997)

Editorials1 August 1997Vitamin D Supplementation: A Word of CautionBernadette M. Marriott, PhDBernadette M. Marriott, PhDNational Institutes of Health; Bethesda, MD 20892Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-3-199708010-00009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Osteoporosis and metabolic bone disease are estimated to affect more than 25 million persons in the United States [1]. Advances in scientific understanding of the development of osteoporosis and its medical treatment and prevention have been dramatic over the past 10 years [2, 3]. It is now clear that what we ingest and probably our exercise patterns throughout life can substantially affect the incidence, severity, and progression of osteoporosis. A critical component of this picture is the role of nutrition [4].Intake of calcium and its regulator, vitamin D, are important in the development and progression of osteoporosis. Vitamin D ...References1. Optimal Calcium Intake. NIH Consensus Statement. 1994; 12:1-31. Google Scholar2. DeLuca H. The vitamin D story: a collaborative effort of basic science and clinical medicine. FASEB J. 1988; 1; 2(3):224-36. Google Scholar3. Sowe MF. Nutrition advances in osteoporosis and osteomalacia. In: Ziegler EE, Filer LJ Jr, eds. Present Knowledge in Nutrition. 7th ed. Washington, DC: ILSI Pr; 1996:456-63. Google Scholar4. Heaney RP. Nutritional factors in osteoporosis. Annu Rev Nutr. 1993; 13:287-316. Google Scholar5. Norman AW. Vitamin D. In: Ziegler EE, Filer LJ Jr, eds. Present Knowledge in Nutrition. 7th ed. Washington, DC: ILSI Pr; 1996:120-9. Google Scholar6. Webb AR, DeCosta BR, Holick MF. Sunlight regulates the cutaneous production of vitamin D3 by causing its photodegradation. 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Google Scholar13. MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985; 76:1536-8. Google Scholar14. Ebeling PR, Sandgren ME, DiMagno EP, Lane AW, DeLuca HF, Riggs BL. Evidence of an age-related decrease in intestinal responsiveness to vitamin D: relationship between serum 1,25-dihydroxyvitamin D3 and intestinal vitamin D receptor concentrations in normal women. J Clin Endocrinol Metab. 1992; 75:176-82. Google Scholar15. Adams JS, Lee G. Gains in bone mineral density with resolution of vitamin D intoxication. Ann Intern Med. 1997; 127:203-6. Google Scholar16. National Research Council. Recommended Dietary Allowances. 10th ed. Washington, DC: National Academy Pr; 1989:96-97. Google Scholar17. Hathcock JN. Quantitative evaluation of vitamin safety. Journal of Practical Nursing. 1986; 36:20-7. Google Scholar18. Food and Nutrition Board. How Should the Recommended Dietary Allowances Be Revised? Washington, DC: National Academy Pr; 1994:1-36. Google Scholar19. Dreyfus PM. Diet and nutrition in neurological disorders. In: Shils ME, Young VE, eds. Modern Nutrition in Health and Disease. Philadelphia: Lea & Febiger; 1988:1458-70. Google Scholar20. National Research Council. Diet and Health: Implications for Reducing Chronic Disease Risk. Washington, DC: National Academy Pr; 1989:517. Google Scholar21. Alexander BH, Rivara FP, Wolf ME. The cost and frequency of hospitalization for fall-related injuries in older adults. Am J Public Health. 1992; 82:1020-3. Google Scholar22. Roe DA. Geriatric Nutrition. 3d ed. Englewood Cliffs, NJ: Prentice-Hall; 1992:196-204. Google Scholar Author, Article, and Disclosure InformationAuthors: Bernadette M. Marriott, PhDAffiliations: National Institutes of Health; Bethesda, MD 20892Corresponding Author: Bernadette M. Marriott, PhD, Office of Dietary Supplements, Office of Disease Prevention, Office of the Director, National Institutes of Health, 7550 Wisconsin Avenue, Suite 610, Bethesda, MD 20892. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoGains in Bone Mineral Density with Resolution of Vitamin D Intoxication John S. 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