tbuckley/cabot-search huggingface dataset:
Code Blue to the MS-III
Authors: Abigail Van Wyk
Journal: Annals of Internal Medicine (2012)

Ad Libitum2 October 2012Code Blue to the MS-IIIAbigail Van WykAbigail Van WykFrom UMDNJ–Robert Wood Johnson Medical School, Piscataway, NJ 08854.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-7-201210020-00005 Audio Reading - “Code Blue to the MS-III” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Code Blue to the MS-III," by A. Van Wyk. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The pulsing beat of monitors keeps time.Annoying? Yes, but opposite is worse;then people run, enacting pantomimewhile fam'lies wait and scream about a curse.ACLS is foreign to me still.I'm flat against the wall and do not stir.The movements blur—each part to play is filled,and I, without a role, just stare at her.Her gown is hiked as fem'rals can't be found—not dignified, but what's it matter now?I see mouths moving, but to me no sound.I wish I could contribute—don't know how.“Her pulse is back—she's saved, good work, let's go!Four discharges await upstairs, you know.”Abigail Van WykUMDNJ–Robert Wood Johnson ... Author, Article, and Disclosure InformationAffiliations: From UMDNJ–Robert Wood Johnson Medical School, Piscataway, NJ 08854.Current Author Address: Abigail Van Wyk; e-mail, [email protected]. PreviousarticleNextarticle Advertisement Audio Reading - “Code Blue to the MS-III” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Code Blue to the MS-III," by A. Van Wyk. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 2 October 2012Volume 157, Issue 7Page: 489KeywordsHeart rateMouth ePublished: 2 October 2012 Issue Published: 2 October 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Specificity of Increased Renal Clearance of Amylase in Diagnosis of Acute Pancreatitis
Authors: A.L. Warshaw, A.F. Fuller
Journal: New England Journal of Medicine (1975)

Renal clearance of amylase from the blood, expressed as a proportion of simultaneous creatinine clearance, is consistent within a narrow range (3.1 per cent ± 1.1 [S.D.]) in normal persons. In patients with acute pancreatitis the amylase/creatinine clearance ratio rises regularly and significantly (9.8 ± 3.5, p < 0.001). Only three of 42 patients with acute pancreatitis had a clearance ratio below 5.3 per cent. In contrast, the amylase/creatinine clearance ratio remained within the normal range in 44 patients with hyperamylasemia due to disease other than pancreatitis. This observation suggests that renal permeability to amylase is altered in acute pancreatitis, and provides a basis for using the amylase/creatinine clearance ratio in the differential diagnosis of hyperamylasemia. (N Engl J Med 292:325–328, 1975)
Sudden Infant Death Syndrome: Another Hypothesis Offered but Doubts Remain
Authors: Paul Cotton
Journal: JAMA (1990)

A MAMMALIAN self-protection mechanism could explain the mystery of sudden infant death syndrome (SIDS), says a University of London researcher. But doubts are being expressed on this side of the Atlantic.  The syndrome incidence peaks at 3 to 4 months of age. Defined as sudden death that is unexpected by history and unexplainable at postmortem examination, SIDS is the leading cause of death in infants aged 28 days to 12 months in the Western world.  However, as with the many other SIDS theories, the latest one appears to offer little help in pinpointing potential victims.  Donald Harrison, MD, PhD, a British professor of laryngology and otology who is offering the latest theory, says milk-dependent animals, including humans, at (the human age equivalent of) 3 to 4 months protect their larynx with high epiglottic folds containing not cartilage, but mucous glands, which allows them to drink quickly.  Lethal Reduction?  Sudden infant
Is the Increased Incidence of Primary Malignant Brain Tumors in the Elderly Real?
Authors: Peter Boyle, Patrick Maisonneuve, Rodolfo Saracci, Calum S. Muir
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Is the Increased Incidence of Primary Malignant Brain Tumors in the Elderly Real? Get access Peter Boyle, Peter Boyle Search for other works by this author on: Oxford Academic PubMed Google Scholar Patrick Maisonneuve, Patrick Maisonneuve Search for other works by this author on: Oxford Academic PubMed Google Scholar Rodolfo Saracci, Rodolfo Saracci Search for other works by this author on: Oxford Academic PubMed Google Scholar Calum S. Muir Calum S. Muir Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 20, 17 October 1990, Pages 1594–1596, https://doi.org/10.1093/jnci/82.20.1594 Published: 17 October 1990 Article history Received: 19 September 1990 Accepted: 20 September 1990 Published: 17 October 1990
Fast-mapping children vs. slow-mapping adults: Assumptions about words and concepts in two literatures
Authors: Gregory L. Murphy
Journal: Behavioral and Brain Sciences (2001)

Research on children's and adults' concepts embodies very different assumptions of how concepts are structured, as reflected in their experimental designs. Developmental studies seem to assume that categories contain highly similar objects that can all be identified from one or two examples. If concepts are more like those tested in adult experiments, research on word learning may be misleading.
Electrolyte and Nutrient Losses from the Gastrointestinal Tract After Bowel Resection or Bypass.
Authors: Arthur B. French
Journal: Annals of Internal Medicine (1969)

s1 May 1969Electrolyte and Nutrient Losses from the Gastrointestinal Tract After Bowel Resection or Bypass.Arthur B. French, M.D., F.A.C.P., H. Bramwell Cook, M.R.A.C.P., Graham M. McLeod, M.R.C.P., Christopher J. Good, M.R.C.P., H. Marvin Pollard, M.D., F.A.C.P.Arthur B. French, M.D., F.A.C.P.Search for more papers by this author, H. Bramwell Cook, M.R.A.C.P.Search for more papers by this author, Graham M. McLeod, M.R.C.P.Search for more papers by this author, Christopher J. Good, M.R.C.P.Search for more papers by this author, H. Marvin Pollard, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1067_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFecal electrolyte and nutrient losses vary greatly with the length of the gastrointestinal tract in continuity and with composition of food ingested. To understand the effect of altering the level of salt intake on these losses, one patient with jejunostomies, seven with jejunocolostomies, three with ileostomies, five with jejunoileostomies, and a normal control were fed either ad libitum diets or constant diets to which salt was added in incremental amounts. Approximate daily stool losses on ad libitum diets were as follows:Stool weight and sodium losses increased linearly in all groups, including the normal control, as salt intake was increased... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Arthur B. French, M.D., F.A.C.P.; H. Bramwell Cook, M.R.A.C.P.; Graham M. McLeod, M.R.C.P.; Christopher J. Good, M.R.C.P.; H. Marvin Pollard, M.D., F.A.C.P.Affiliations: Ann Arbor, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySynthesis, Alkylation and Reduction of 4‐Aryl‐2 H ‐1,2,3‐benzothiadiazine 1,1‐dioxides 1 May 1969Volume 70, Issue 5Page: 1067-1067KeywordsColectomyDietFoodGastrointestinal tractIleostomyNutrientsSaltsSodiumWeight loss ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
Workplace wellness programs show little benefit, US report says
Authors: M. McCarthy
Journal: BMJ (2013)

A study by the RAND Corporation has found that workplace wellness programs designed to promote employee health and fitness seem to have, at best, a modest effect, Reuters reported over the weekend.

Such wellness programs have become popular among US employers seeking to reduce health costs and boost worker productivity.

A 2012 survey by the Kaiser Family Foundation and Health Research and Educational Trust found that 63% of companies with three or more employees that offered health benefits also offered at least …
Type-Specific Epitope Locations Revealed by X-Ray Crystallographic Study of Adenovirus Type 5 Hexon
Authors: John J. Rux, Roger M. Burnett
Journal: Molecular Therapy (2000)

A major obstacle to the use of adenovirus as a vector for gene therapy is the host immune response to hexon, the major protein component of the icosahedral capsid. A solution lies in creating novel vectors with modified or chimeric hexons to evade the immune response to native hexon. The crystal structure of hexon from human adenovirus type 5 (ad5), the type primarily used for gene therapy, has been determined to facilitate the design of such molecules. As the 951-amino-acid (aa) ad5 hexon sequence is closely related to that of ad2 (967 aa; 86% aa identity), the ad5 structure was solved by molecular replacement with a model constructed from the known ad2 hexon. During refinement, greater than 25% of the sequence was reassigned, resulting in a relocation of two epitope regions, from buried positions in the ad2 model to external sites at the top of the ad5 molecule. The resultant model is in better agreement with crystallographic data, while maintaining the overall topology of ad2 hexon. This work suggests that all hexons have the same basic fold and that the ad5 hexon structure provides an accurate and representative model for designing new adenovirus vectors.
Work-Related Vascular Injuries of the Hand — Hypothenar Hammer Syndrome
Authors: Manuela Birrer, Iris Baumgartner
Journal: New England Journal of Medicine (2002)

Figure 1. A 47-year-old construction worker reported a two-month history of blanching of the second to fifth fingers and a recent ulcer on the tip of the third finger of his right hand. One week before the onset of symptoms, he had straightened a slab of iron with a hammer. Angiography (Panel A) revealed an aneurysm of the distal ulnar artery measuring 5 mm in diameter (large arrowhead) and occlusions of digital branches presumed to be secondary to thromboembolism (small arrowheads). Surgery revealed a partially thrombosed false aneurysm of the ulnar artery, which was resected. The postoperative course was uneventful, . . .
A Novel Approach to Preventing Insect-Borne Diseases
Authors: J E Conte
Journal: New England Journal of Medicine (1997)

Insects and humans have lived together successfully for many years — the oldest insect fossil is probably more than 390 million years old. Insects have evolved into approximately a million named species that occupy an important place in the world's ecosystem. They also carry microbes and parasites that affect humans (Chagas' disease, Lyme disease, malaria, bubonic plague, and dengue) and other animals and damage food crops (locusts), cotton (boll weevils), trees (gypsy moths), and homes (termites). The total economic cost of insect-related damage and illness is immeasurable but is probably many billions of dollars annually worldwide. To control insects and . . .
Elevation of IgA anti-epidermal transglutaminase antibodies in dermatitis herpetiformis
Authors: C.M. Hull, M. Liddle, N. Hansen, L.J. Meyer, L. Schmidt, T. Taylor, T.D. Jaskowski, H.R. Hill, J.J. Zone
Journal: British Journal of Dermatology (2008)

Dermatitis herpetiformis (DH) is a papulovesicular eruption caused by ingestion of gluten. It is characterized by the deposition of IgA in the dermal papillae. IgA antibodies directed at tissue transglutaminase (TG2) are elevated in gluten-sensitive diseases including DH and coeliac disease (CD). More recently, antibodies directed at epidermal transglutaminase (TG3) were identified in patients with DH, and this may be the dominant autoantigen in this disease.To measure IgA antibodies to TG3 and TG2 in patients with DH and CD, and control populations.Serum IgA antibodies against TG2 and TG3 were measured from adults with DH, adults and children with CD, patients with psoriasis, adult Red Cross blood donors, and paediatric controls.Patients with DH and CD had elevated levels of IgA anti-TG2 antibodies compared with control populations. The levels in the patients with DH and adults with CD were similar. IgA anti-TG2 antibodies were higher in the children with CD compared with adults with DH and CD, and with control populations. Patients with DH and adults with CD had elevated levels of IgA anti-TG3 antibodies compared with children with CD and control populations. There was a trend towards higher levels in the patients with DH compared with adults with CD.IgA antibodies to TG3 are elevated in patients with DH and adults with CD. The progressive expansion of the epitope-binding profile of IgA antitransglutaminase antibodies in patients with CD may explain the development of DH in patients with undiagnosed CD during their adult life.
Cetuximab-Associated Acneiform Eruption
Authors: Jeremy E Moss, Barbara Burtness
Journal: New England Journal of Medicine (2005)

This 48-year-old man with metastatic colon cancer was treated with cetuximab, a monoclonal antibody to EGFR. An eruption of sterile papules and pustules with adherent crust developed on his face, chest, and back.
Bone-protective Effects of Nonviral Gene Therapy With Folate–Chitosan DNA Nanoparticle Containing Interleukin-1 Receptor Antagonist Gene in Rats With Adjuvant-induced Arthritis
Authors: Julio C Fernandes, Huijie Wang, Christian Jreyssaty, Mohamed Benderdour, Patrick Lavigne, Xingpin Qiu, Francoise M Winnik, Xiaoling Zhang, Kerong Dai, Qin Shi
Journal: Molecular Therapy (2008)

Interleukin-1 receptor antagonist (IL-1Ra), is a natural blocker of the inflammatory cytokine interleukin-1. Using a rat adjuvant-induced arthritis (AIA) model of rheumatoid arthritis (RA), we examined the protective effects of IL-1Ra in bone metabolism in vivo after folate-mediated nonviral gene delivery. We detected secreted human IL-1Ra protein in serum and cultured primary osteoblasts of rats that were treated with chitosan–IL-1Ra and folate–IL-1Ra–chitosan nanoparticles, respectively. In vivo, IL-1Ra gene delivery significantly reverted alterations in bone turnover observed in arthritic animals by modulating the level of osteocalcin (OC) as well as the activities of alkaline phosphatase and tartrate-resistant acid phosphatase. The protective effects of these nanoparticles were evident from the decrease in the expression levels of interleukine-1β and prostaglandin E2 as well as osteoclast number and other histopathological findings. Compared to naked DNA and chitosan–DNA, folate–chitosan–DNA nanoparticles were less cytotoxic and enhanced IL-1Ra protein synthesis in vitro and offered a better protection against inflammation and abnormal bone metabolism in vivo. Nonviral gene therapy with folate–chitosan–DNA nanoparticles containing the IL-1 Ra gene seemed to protect against bone damage and inflammation in rat adjuvant-induced arthritis model. Interleukin-1 receptor antagonist (IL-1Ra), is a natural blocker of the inflammatory cytokine interleukin-1. Using a rat adjuvant-induced arthritis (AIA) model of rheumatoid arthritis (RA), we examined the protective effects of IL-1Ra in bone metabolism in vivo after folate-mediated nonviral gene delivery. We detected secreted human IL-1Ra protein in serum and cultured primary osteoblasts of rats that were treated with chitosan–IL-1Ra and folate–IL-1Ra–chitosan nanoparticles, respectively. In vivo, IL-1Ra gene delivery significantly reverted alterations in bone turnover observed in arthritic animals by modulating the level of osteocalcin (OC) as well as the activities of alkaline phosphatase and tartrate-resistant acid phosphatase. The protective effects of these nanoparticles were evident from the decrease in the expression levels of interleukine-1β and prostaglandin E2 as well as osteoclast number and other histopathological findings. Compared to naked DNA and chitosan–DNA, folate–chitosan–DNA nanoparticles were less cytotoxic and enhanced IL-1Ra protein synthesis in vitro and offered a better protection against inflammation and abnormal bone metabolism in vivo. Nonviral gene therapy with folate–chitosan–DNA nanoparticles containing the IL-1 Ra gene seemed to protect against bone damage and inflammation in rat adjuvant-induced arthritis model.
Hemorrhagic State Due to Surreptitious Ingestion of Bishydroxycoumarin
Authors: Robert A. O'Reilly, Paul M. Aggeler, John O. Gibbs
Journal: New England Journal of Medicine (1962)

Surreptitious use of an anticoagulant drug poses a baffling diagnostic problem, since the symptoms may simulate those of a congenital coagulation defect, vitamin K deficiency or liver disease. The first case of a bleeding disorder resulting from surreptitious ingestion of a prothrombinopenic anticoagulant drug was described by Stafne and Moe1 in 1951; subsequently, 8 additional cases were reported.2 3 4 5 6 In all 9, the correct diagnosis was established with great difficulty. A congenital clotting--factor deficiency was usually the initial clinical impression. In most cases the correct diagnosis was suspected when multiple clotting-factor deficiencies were found, corresponding to those resulting from ingestion of . . .
Bitter Medicine: The Saskatchewan Medicare Feud
Authors: Charles G. Roland
Journal: JAMA (1964)

This book ought to be dull. That it is not is both a tribute to the style of the author and a commentary on the vitality of the subject to us all. To say that I read the book at a sitting would be trite but true.  In bald fact, this is a legal brief, but the brief is held for neither side in the Saskatchewan Medicare feud. In clear prose the writer analyzes the Medical Care Insurance Act passed by the recently defeated socialist government of Saskatchewan in 1961, and the ensuing struggle between this government and organized medicine in the province. His analysis is made from one viewpoint only—the status of the act and the subsequent amendments, proposals, and agreements in their relation to Canadian law.  Mr. Tollefson, a practicing lawyer, does not explore the desirability of a universal compulsory scheme. He concerns himself with legality, not philosophy.
Assault on a GP.
Authors: S Cembrowicz, P G Ford, J C Winn, M Goodman, C Dyer
Journal: BMJ (1987)

We received a paperfrom Dr Cembrowicz describing an attack on him in his surgery in an inner city area.He was unable to practisefor two weeks because ofinjuries, and in the event had to apply to the Criminal Injuries Compensation Board for compensation.We asked someone from a medical defence society, someone from an insurance company, a general practitioner, and a lawyer to comment on Dr Cembrowiczs case.The assault I heard a commotion through my door.Outside I found my senior partner being furiously accosted by a young man wearing an anorak with the hood drawn up.He appeared wildly angry and was accusing my partner of sending him electricity bills.Violence seemed imminent, and I tried to usher our patient away, laying a gentle hand on his arm.This triggered several blows to my face, and I found I was defending myself
Surgery, AIDS, and Hepatitis B-Reply
Authors: Julie Louise Gerberding
Journal: JAMA (1991)

<h3>In Reply.</h3> — I wholeheartedly agree with Dr Boscia's position that hepatitis B immunization must receive the highest priority in programs for preventing occupational blood-borne infections. Policies that offer vaccination to all health care workers at the time of entry into professional and training schools or at the time of employment are justifiable by the high transmissibility of hepatitis B virus in the health care setting, and vaccination should be mandated to protect both patients and their providers. The concept of procedure-specific infection control includes all aspects of a procedure that could influence exposure risk, including the circumstances under which the procedure is performed, in assessing indications for specific infection control interventions. Dr Peterson argues for evaluation of the benefits and risks associated with new interventions to reduce blood exposures before widespread implementation. I concur with this view and strongly encourage surgical personnel to take an active role in identifying
Vitamin K for Chilblains
Authors: D. P. Wheatley
Journal: BMJ (1947)

Keratodermia punctata is a very rare disease.The follow- ing case is a good example of it and fulfils the criteria for diagnosis postulated by Sweitzer'(1923), who stated that "the true keratoderma punctatum should not show a generalized hyperkeratosis or any erythema at the edges of the lesions."Cleveland White (1930) had a similar case treated by chiropody for twelve years without improvement.My patient had been treated' by a chiropodist for two months without success. Case ReportA gunner aged 32 was admitted to a general hospital in B.L.A with a provisional diagnosis of " ?multiple verrucae of hands."After examination and investigation keratodermia punctata was diagnosed.The patient had had no previous
Extended analysis of the spot sign score's performance
Authors: Josser E. Delgado Almandoz, Albert J. Yoo, Michael J. Stone, Pamela W. Schaefer, Joshua N. Goldstein, Jonathan Rosand, Alexandra Oleinik, Michael H. Lev, R. Gilberto Gonzalez, Javier M. Romero
Journal: Nature Reviews Neurology (2010)
Platelet glycoprotein Ibα forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF
Authors: Tadayuki Yago, Jizhong Lou, Tao Wu, Jun Yang, Jonathan J. Miner, Leslie Coburn, José A. López, Miguel A. Cruz, Jing-Fei Dong, Larry V. McIntire, Rodger P. McEver, Cheng Zhu
Journal: Journal of Clinical Investigation (2008)

Arterial blood flow enhances glycoprotein Ibα (GPIbα) binding to vWF, which initiates platelet adhesion to injured vessels. Mutations in the vWF A1 domain that cause type 2B von Willebrand disease (vWD) reduce the flow requirement for adhesion. Here we show that increasing force on GPIbα/vWF bonds first prolonged ("catch") and then shortened ("slip") bond lifetimes. Two type 2B vWD A1 domain mutants, R1306Q and R1450E, converted catch bonds to slip bonds by prolonging bond lifetimes at low forces. Steered molecular dynamics simulations of GPIbα dissociating from the A1 domain suggested mechanisms for catch bonds and their conversion by the A1 domain mutations. Catch bonds caused platelets and GPIbα-coated microspheres to roll more slowly on WT vWF and WT A1 domains as flow increased from suboptimal levels, explaining flow-enhanced rolling. Longer bond lifetimes at low forces eliminated the flow requirement for rolling on R1306Q and R1450E mutant A1 domains. Flowing platelets agglutinated with microspheres bearing R1306Q or R1450E mutant A1 domains, but not WT A1 domains. Therefore, catch bonds may prevent vWF multimers from agglutinating platelets. A disintegrin and metalloproteinase with a thrombospondin type 1 motif–13 (ADAMTS-13) reduced platelet agglutination with microspheres bearing a tridomain A1A2A3 vWF fragment with the R1450E mutation in a shear-dependent manner. We conclude that in type 2B vWD, prolonged lifetimes of vWF bonds with GPIbα on circulating platelets may allow ADAMTS-13 to deplete large vWF multimers, causing bleeding.