Renal Impairment Associated with Losartan
Authors: Deborah R. Saine
Journal: Annals of Internal Medicine (1996)

Letters15 April 1996Renal Impairment Associated with LosartanDeborah R. Saine, RPh and Edward R. Ahrens, MDDeborah R. Saine, RPhMeriter Hospital; Madison, WI 53715 and Edward R. Ahrens, MDMeriter Hospital; Madison, WI 53715Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-8-199604150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Losartan, the first angiotensin II receptor antagonist, is used to treat hypertension. We report a case of renal impairment associated with this drug.A 77-year-old woman began receiving losartan, 50 mg/d, for hypertension. Concomitant medications included long-term use of allopurinol for gout. The patient's serum creatinine level at that time was 132.6 µmol/L (1.5 mg/dL). Six weeks later, the patient was hospitalized with a 1- to 2-week history of diarrhea and anorexia. On admission, her serum creatinine level was 327.1 µmol/L (3.7 mg/dL), and her blood urea nitrogen level was 36.1 mmol/L (101 mg/dL). The patient was ...REFERENCE1. Hricik DE, Dunn MJ. Angiotensin-converting enzyme inhibitor-induced renal failure: causes, consequences, and diagnostic uses. J Am Soc Nephrol. 1990; 1:845-58. Google Scholar Author, Article, and Disclosure InformationAuthors: Deborah R. Saine, RPh; Edward R. Ahrens, MDAffiliations: Meriter Hospital; Madison, WI 53715 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInhibiteurs de l'aminopeptidase A comme nouveau traitement potentiel de l'hypertension artérielleStructural Insights into Central Hypertension Regulation by Human Aminopeptidase ACentral Antihypertensive Effects of Orally Active Aminopeptidase A Inhibitors in Spontaneously Hypertensive RatsThe role of the brain renin–angiotensin system in hypertension: Implications for new treatmentThe epidemiology of drug-induced disorders: the kidneyAminopeptidase A inhibitors as centrally acting antihypertensive agentsJacques Benoit Lecture: The Neuroendocrine View of the Angiotensin and Apelin SystemsAngiotensin II Receptor AntagonistsAminopeptidase Inhibitors as Anti-Hypertensive DrugsAcute Renal Failure Secondary to Angiotensin II Receptor Blockade in a Patient with Bilateral Renal Artery StenosisFracaso renal agudo por irbesartánReversible renal impairment induced by treatment with the angiotensin II receptor antagonist candesartan in a patient with bilateral renal artery stenosisAcute oliguric renal failure associated with angiotensin II receptor antagonistsAngiotensin II receptor antagonists: well tolerated and effective antihypertensivesREPEATED TRANSIENT ANURIA FOLLOWING LOSARTAN ADMINISTRATION IN A PATIENT WITH A SOLITARY KIDNEYAngiotensin II receptor antagonistsEND-STAGE RENAL FAILURE AFTER IRBESARTAN PRESCRIPTION IN A DIABETIC PATIENT WITH PREVIOUSLY STABLE CHRONIC RENAL INSUFFICIENCYHepatic Injury Associated with LosartanLosartan as an Alternative to ACE Inhibitors in Patients with Renal DysfunctionPerioperative HypertensionLosartan potassium 15 April 1996Volume 124, Issue 8Page: 775KeywordsAllopurinolBlood urea nitrogenCreatinineDiureticsHypertensionRenal diseasesRenal failureType 2 diabetesUltrasound imagingVascular diseases ePublished: 15 August 2000 Issue Published: 15 April 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...