tbuckley/cabot-search huggingface dataset:
Carbon Monoxide and Dermal Changes
Authors: H. Ippen
Journal: JAMA (1969)

To the Editor:—  In Long's article about dermal changes associated with carbon monoxide intoxication (205:50, 1968), morphology, course, and histologic manifestations correspond completely to the skin lesions, which can also be seen after barbiturate intoxication and following protracted unconsciousness due to other causes or long-continued narcosis. This is not a matter of some specific effect of barbiturate or carbon monoxide on the skin. These are single decubital lesions resulting from long-continued hypoxemia due to compression.  Therefore erythema, edema, bullous lesions, and eschar formation can only be found on those parts of the body which were compressed by the position of the patient.  In all our cases we were able to account easily for each lesion—of one ear, on the head, arm, both knees, or the heels—as corresponding simply to pressure areas. Precondition for the origin of these lesions is consequently not some kind of a poison but only the
Pathological diagnosis of liver cell adenoma and focal nodular hyperplasia: Bordeaux update
Authors: P. Bioulac-Sage, C. Balabaud, P. Bedossa, J.Y. Scoazec, L. Chiche, A.P. Dhillon, L. Ferrell, V. Paradis, T. Roskams, V. Vilgrain, I.R. Wanless, J. Zucman-Rossi
Journal: Journal of Hepatology (2007)
Unexplained Noncardiac Chest Pain
Authors: Frank P. Castrina
Journal: Annals of Internal Medicine (1997)

Letters15 April 1997Unexplained Noncardiac Chest PainRonnie Fass, MDRonnie Fass, MDTucson Veterans Affairs Medical Center, Tucson, AZ 85723Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-8-199704150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with great interest the recent article by Rao and colleagues [1]. However, I have several methodologic concerns that could affect the results of this study. When esophageal sensory perception thresholds are assessed, general or local anesthesia should be avoided. Local anesthesia, which can be swallowed and can potentially alter esophageal perception, was used in this study.In addition, the authors used pressure to determine thresholds of esophageal perception. We have found that pressure is a much less accurate variable than volume because it is greatly influenced by esophageal contractions in response to balloon distention [2]. ...References1. Rao SS, Gregersen H, Hayek B, Summers RW, Christensen J. Unexplained chest pain: the hypersensitive, hyperreactive, and poorly compliant esophagus. Ann Intern Med. 1996; 124:950-8. Google Scholar2. Fass R, Munakata J, Nabiloff B, Syntik B, Kodner A, Perez M, et al. Characterization of esophageal afferent function in healthy normal subjects. Am J Gastroenterol. 1995; 90:1574. Google Scholar Author, Article, and Disclosure InformationAffiliations: Tucson Veterans Affairs Medical Center, Tucson, AZ 85723 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1997Volume 126, Issue 8Page: 662KeywordsAnesthesiaIschemiaPerceptionReproducibility Issue Published: 15 April 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Immunological and immunoassay studies of the binding protein for vitamin D and its metabolites in human serum.
Authors: M Imawari, D S Goodman
Journal: Journal of Clinical Investigation (1977)

This study reports the development of a specific and sensitive radioimmunoassay and a simple and accurate radial immunodiffusion (RID) assay for the human serum-binding protein for vitamin D and its metabolites (DBP). These immunoassays employed a monospecific antiserum that was prepared in rabbits against human DBP. The radioimmunoassay effectively measured DBP in amounts of 1-10 ng, whereas the RID assay measured DBP accurately in amounts of 0.2-0.8 mug. The results obtained with the two immunoassays on the same samples of serum agreed well with each other. Using the RID assay, the mean (+/- SD) serum DBP concentration observed in 35 normal persons was 422 +/- 27 micrograms/ml. Generally similar levels were observed in 66 hyperlipidemic subjects. In molar terms, the mean DBP concentration (approximately 8 microgramsM) was of the order of 50 times the usual serum level of 25-hydroxyvitamin D (25-OH-D) plus vitamin D. Thus, most of plasma DBP circulates as apo-DBP, not containing a bound molecule of 25-OH-D or of vitamin D. DBP and 25-OH-D concentrations were measured in a limited number of patients with hypercalcemia, mild hypocalcemia, and markedly elevated serum 25-OH-D levels due to oral vitamin D supplementation. It was found that major changes can occur in the serum levels of 25-OH-D and of calcium with very little or no associated changes occurring in the serum concentration of DBP, The results suggest that neither serum 25-OH-D nor serum calcium plays an important role in the regulation of the metabolism of DBP. Data were obtained that confirmed and extended an earlier report on the identity of the group-specific component (Gc) protein in plasma with the plasma vitamin D-binding protein. On immunodiffusion against whole serum, the line formed with the anti-DBP antiserum showed a complete reaction-of-identity with the line formed with commercial antiserum against Gc protein. Furthermore, serum that had been depleted of DBP by treatment with Sepharose containing covalently coupled antibodies against DBP was found to be depleted also of immunoreactivity against anti-GC protein antiserum. In addition, the properties of the purified DBP preparation agreed closely with those previously reported by others for Gc protein. Finally, a comparative immunology study showed that sera from several different mammalian orders showed some immunoreactivity against the antihuman DBP antiserum. Thus, proteins immunologically similar to human DBP are present in sera from a number of mammalian species and orders.
NHS is failing to reap benefit of new technologies, MPs say
Authors: Susan Mayor
Journal: BMJ (2005)

The NHS must overcome its preference for short term savings and develop strategies to stop the current underuse of new medical technologies, a parliamentary advisory committee recommended in a report published last week.

The House of Commons Health Committee, an all party committee of MPs that scrutinises Department of Health expenditure and policy, found that the potential benefits of new medical technologies, including telemedicine and computer systems, were not being realised by the NHS. The report noted that the …
Community Research Partnerships
Authors: Jennifer Kulynych, Kate Gallin Heffernan
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of protein kinase inhibitors on radiation-induced WAF1 accumulation in human cultured melanoma cells
Authors: None Fujino, None Ohnishi, None Asahi, None Wang, None Takahashi, None Ohnishi
Journal: British Journal of Dermatology (1999)

To examine whether protein kinase C (PKC) and A (PKA) contribute to WAF1 induction by ionizing radiation (IR) in cultured human melanomas, the effect of PK inhibitors 1‐(5′‐isoquinolinesulphonyl)‐2‐methylpiperazine dihydrochloride (H7), bisindolylmaleimide (GF) and N‐[2(p‐dromocinnamylamino)ethyl]‐5‐isoquinolinesulphonamide (H89) on IR‐induced WAF1 accumulation was analysed by Western blot analysis. Gamma‐ray‐induced accumulation of WAF1 showed a peak at 6 Gy in all the cell lines. After γ‐ray irradiation of 6 Gy, a peak of WAF1 accumulation was observed at 6 h in SK‐Mel‐26, G361 and HM6KO cells, and at 3 h in MeWo cells. In MeWo and SK‐Mel‐26 cells, the X‐ray‐induced WAF1 accumulation was decreased by PK inhibitors, GF (PKC inhibitor) or H89 (PKA inhibitor); this did not occur in G361 and HM6KO. In all the cell lines, accumulation of WAF1 induced by X‐ray irradiation was suppressed by H7 (PKC and PKA inhibitor). In addition, polymerase chain reaction–single strand conformational polymorphism analysis detected no aberrations in the p53 gene of the four cell lines used. These results suggest that IR‐induced WAF1 expression involves PKC and/or PKA activity depending on cell type.
Studies of the Retinal Circulation in Man
Authors: JOHN B. HICKAM, REGINA FRAYSER
Journal: Circulation (1966)

By photographic techniques measurements have been made in the human retina of vessel size, arteriovenous oxygen difference across the retina, and mean retinal circulation time. By combination of these methods estimates can be made of relative changes in retinal blood flow rate and in the rate of oxygen delivery from the retinal vascular system. Observations are presented on the response of the normal and diseased retinal circulation to a variety of stimuli, particularly changes in blood oxygen and carbon dioxide tensions.
“Granulomatosis With Polyangiitis (Wegener's)” for “Wegener Granulomatosis”
Authors: Claude Bachmeyer, Bruno Halioua
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Socioeconomic determinants of health: The contribution of nutrition to inequalities in health
Authors: W P. T James, M. Nelson, A. Ralph, S. Leather
Journal: BMJ (1997)

<h3>Abstract</h3> Social class differences in health are seen at all ages, with lower socioeconomic groups having greater incidence of premature and low birthweight babies, heart disease, stroke, and some cancers in adults. Risk factors including lack of breast feeding, smoking, physical inactivity, obesity, hypertension, and poor diet are clustered in the lower socioeconomic groups. The diet of the lower socioeconomic groups provides cheap energy from foods such as meat products, full cream milk, fats, sugars, preserves, potatoes, and cereals but has little intake of vegetables, fruit, and wholewheat bread. This type of diet is lower in essential nutrients such as calcium, iron, magnesium, folate, and vitamin C than that of the higher socioeconomic groups. New nutritional knowledge on the protective role of antioxidants and other dietary factors suggests that there is scope for enormous health gain if a diet rich in vegetables, fruit, unrefined cereal, fish, and small quantities of quality vegetable oils could be more accessible to poor people.
ON THE CARE OF EPILEPTICS.Read before the Section of Neurology and Medical Jurisprudence, at the Forty-fourth Annual Meeting of the American Medical Association.
Authors: FREDERICK PETERSON
Journal: JAMA (1893)

The care of epileptics really includes their medical treatment as well as all other kinds of help extended to them. But medical care, such as it is, has been given to them for some thousands of years, and yet without adding much to the happiness of individuals under treatment, or accumulating much evidence of positive value concerning medication in epilepsy. Our results have been, indeed, almost valueless; for, with all our dosing with bromids, borax, belladonna and so on through the alphabetical index of the Pharmacopoeia, it is extremely doubtful if in ordinary practice, 1 per cent, of the cases of idiopathic epilepsy are cured. Besides the practical incurability and hopelessness of the disease, its victims have suffered untold sorrows in the way of negligence and illtreatment at the hands of the communities in which they live. It is a peculiarity of this disease that the seizures may be momentary
PREVALENCE, CHARACTERISTICS AND PREDICTIVE VALUE OF SEVERE RESISTANT HYPERTENSION FOR THE INCIDENCE OF CARDIOVASCULAR DISEASE
Authors: A. Kasiakogias, K. Tsioufis, D. Tsiachris, I. Anastasopoulos, D. Flessas, P. Hatziyiannis, I. Tatsis, I. Leontsinis, D. Tousoulis, C. Stefanadis
Journal: Journal of the American College of Cardiology (2012)
Thioredoxin
Authors: Hideyuki Yamawaki, Judith Haendeler, Bradford C. Berk
Journal: Circulation Research (2003)

The thioredoxin (TRX) system (TRX, TRX reductase, and NADPH) is a ubiquitous thiol oxidoreductase system that regulates cellular reduction/oxidation (redox) status. The oxidation mechanism for disease pathogenesis states that an imbalance in cell redox state alters function of multiple cell pathways. In this study, we review the essential role for TRX to limit oxidative stress directly via antioxidant effects and indirectly by protein-protein interaction with key signaling molecules, such as apoptosis signal-regulating kinase 1. We propose that TRX and its endogenous regulators are important future targets to develop clinical therapies for cardiovascular disorders associated with oxidative stress.
Prolonged Thrombin Inhibition Reduces Restenosis After Balloon Angioplasty in Porcine Coronary Arteries
Authors: Richard Gallo, Adrian Padurean, Vincenzo Toschi, Johan Bichler, John T. Fallon, James H. Chesebro, Valentin Fuster, Juan J. Badimon
Journal: Circulation (1998)

Background —Arterial injury after percutaneous transluminal coronary angioplasty (PTCA) triggers acute thrombus formation and thrombin generation. Hirudin, a potent and direct thrombin inhibitor, prevents thrombus formation after arterial injury. Two large clinical trials showed marked reduction in acute clinical events but no long-term benefits in reducing restenosis during short-term administration of thrombin inhibitors. Our hypothesis is that adequate, maintained thrombin inhibition, by inhibiting all the thrombin-dependent mechanisms, will reduce neointima formation after PTCA. Methods and Results —Thirty-six pigs received three different regimens of hirudin: bolus (1 mg/kg), short-term (bolus+0.7 mg/kg per day for 2 days), and long-term (bolus+0.7 mg/kg per day for 14 days). The results on neointima formation at 4 weeks after coronary angioplasty were compared with the control group (100 IU heparin/kg bolus). Hirudin was continuously administered for 2 weeks through an infusion pump. In vivo thrombin generation was persistently increased up to 2 weeks after angioplasty. Inhibition of thrombin activity for 14 days reduced luminal narrowing by 40% (58±3% versus 35±3%; P &lt;.001). No differences were observed among the bolus and short-term hirudin groups and the control group. Conclusions —Our results indicate that there is a continued, marked thrombin generation that lasts for at least 2 weeks after PTCA. Administration of r-hirudin for 2 weeks significantly reduces neointima formation after PTCA. This observation, if extrapolated to humans, could explain the lack of effect on restenosis observed in the clinical trials with antithrombin agents despite the clear benefits on reducing acute thrombotic complications after PTCA. Therefore an adequate and prolonged administration of thrombin inhibitors is needed to “passivate” the thrombogenic substrate (disrupted arterial wall) and achieve full benefit of this therapeutic approach.
Two-, six-, and 12-minute walking tests in respiratory disease.
Authors: R J Butland, J Pang, E R Gross, A A Woodcock, D M Geddes
Journal: BMJ (1982)

Over the ensuing seven months she had three more clinical relapses, each accompanied by reappearance in the stools of either the organism or its cytotoxin, or both.Each improvement after vancomycin (eight to 14-day- courses) was accompanied by disappearance of the organism.At one point she was given cholestyramine, but she was unable to tolerate it.Her illness was punctuated by malnutrition and episodes of heart failure.She was given no other antibiotics.After the sixth relapse maintenance treatment with oral vancomycin 125 mg eight-hourly was begun.With this regimen diarrhoea was controlled and stools over the next 10 weeks remained negative for C difficile and its cytotoxin.There was no adverse reaction to vancomycin throughout.
Reduction in lung cancer deaths is lagging behind that in other common cancers
Authors: Z. Kmietowicz
Journal: BMJ (2013)

The proportion of UK people with diagnosed breast, prostate, or colorectal cancer who die from their cancer will have fallen by 44% by 2020, from the 1992 figure, while deaths from lung cancer will have fallen by only 16%, shows a new analysis by the charity Macmillan Cancer Support.1

The analysis estimated the proportion of people with a diagnosis of one of the four commonest cancers in the UK in a given year who …
Herpes simplex infection at term. What to do with mother, newborn, and nursery personnel
Authors: S. Kibrick
Journal: JAMA (1980)

LITTLE has been published regarding infection control procedures for the woman with an active herpetic infection at term, or for her newborn infant. As yet, no authoritative body has addressed itself to these points in generally available journals. There is also no current agreement on the criteria for cesarean section in the woman with genital herpes infection at term and no uniform policy for managing nursery personnel with herpetic lesions on exposed body surfaces. That guidelines are needed is apparent from numerous requests to our unit for advice on dealing with such problems.  In this article, the risks to the newborn arising from herpetic infection in the mother at term are considered and the possible role of cesarean section in minimizing these risks is reviewed. Based on these data, recommendations for treating such mothers are made. In addition, we suggest infection control procedures for the mothers, their newborns, and for
Restrictive law on reproduction increases multiple pregnancies
Authors: Fabio Turone
Journal: BMJ (2007)

The first official data on the effects of the restrictive Italian law on assisted reproduction, approved in 2004, have been made public by health minister Livia Turco, of the centre left coalition government led by the former president of the European Union Romano Prodi.

According to Ms Turco's report to parliament, the law has resulted in a decrease in the success rate of the procedures and more multiple pregnancies and adverse outcomes.

The law was approved during the previous centre right government by a cross party majority. It prohibits the use of …
TNF-α induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A2 activation
Authors: Il-Whan Choi, None Sun-Kim, Young-Suk Kim, Hyun-Mi Ko, Suhn-Young Im, Jae-Hong Kim, Hye-Jin You, Yong-Chul Lee, Jae-Hoon Lee, Young-Min Park
Journal: Journal of Allergy and Clinical Immunology (2005)
Myocardial Blood Flow, Glucose Uptake, and Recruitment of Inotropic Reserve in Chronic Left Ventricular Ischemic Dysfunction
Authors: Bernhard L. Gerber, Jean-Louis J. Vanoverschelde, Anne Bol, Christian Michel, Daniel Labar, William Wijns, Jacques A. Melin
Journal: Circulation (1996)

Background Previous work has documented that dysfunctional noninfarcted collateral-dependent myocardium, a condition typical of myocardial hibernation, exhibited almost normal resting perfusion. The present study was designed to test whether these observations could be extended to unselected patients with chronic dysfunction and a previous infarction. Methods and Results Dynamic positron emission tomographic imaging with [ 13 N]ammonia and [ 18 F]fluorodeoxy-glucose (FDG) to assess myocardial perfusion and glucose uptake was performed in 39 patients with chronic anterior wall dysfunction undergoing coronary revascularization. Left ventricular function was evaluated by echocardiography before (at rest and during low-dose dobutamine infusion) and 5 months after revascularization. At follow-up, wall motion was improved in 24 patients and unchanged in 15 patients. Before revascularization, absolute myocardial blood flow was higher (84±27 versus 60±26 mL·min − 1 ·100 g − 1 , P =.007) in reversibly compared with persistently dysfunctional segments. In segments with reversible dysfunction, values of myocardial blood flow were similar to those in the remote segments of the same patients or in anterior segments of normal volunteers. During glucose clamp, FDG uptake was higher (69±17% versus 49±18%, P &lt;.01) but myocardial glucose uptake was not different (38±20 versus 29±19 μmol·min − 1 ·100 g − 1 , P =NS) in reversibly compared with persistently dysfunctional segments. A flow-metabolism mismatch was present in 18 of 24 reversibly injured but absent in 10 of 15 persistently dysfunctional segments. With dobutamine, wall motion improved in 17 of 24 reversibly dysfunctional segments and did not change in 13 of 15 segments with persistent dysfunction. Conclusions This study indicates that chronic but reversible ischemic dysfunction is associated with almost normal resting myocardial perfusion, with maintained FDG uptake, and with recruitable inotropic reserve. These data support the contention that chronic hibernation is not the consequence of a permanent reduction of transmural myocardial perfusion at rest.