tbuckley/cabot-search huggingface dataset:
Cervical Internal Carotid Aneurysm From Syphilis—An Alternative to Resection
Authors: Joseph C. Avellone
Journal: JAMA (1979)

<h3>To the Editor.—</h3> Syphilis is now rarely reported as a cause of internal carotid artery aneurysm<sup>1</sup>; more characteristically, it involves the ascending aorta. The diagnosis requires serological testing because pathological findings may be difficult to demonstrate. We describe a patient with syphilitic aneurysm of the internal carotid artery that was treated by progressive clamping. <h3>Report of a Case.—</h3> A 24-year-old hypertensive woman was seen in August 1970 with a five-day history of left periorbital pain and a 48-hour bout of numbness, tingling, and weakness of the right hand, which subsided. Results of serological tests for syphilis and fluorescent treponemal antibody were positive. A radionuclide study was suggestive of aneurysm of the left internal carotid artery; this diagnosis was confirmed by angiography (Fig 1). The intracranial circulation was normal and did not demonstrate crossover. The patient was treated for tertiary syphilis and was readmitted in September 1974 with headache but
Standards for the use of ordinal scales in clinical trials.
Authors: C R MacKenzie, M E Charlson
Journal: BMJ (1986)

Ordinal scales are frequently used in clinical trials to quantify outcomes which are non-dimensional. They may be regarded as either single state or transition measures based on whether they assess the outcome at a single point in time or directly examine change which has occurred between two points in time. Each has unique structural and operating characteristics, so that different methodological standards for their construction and utilisation are required. All trials employing ordinal scales published in three leading journals between 1980 and 1984 were examined. For both types of scales the individual ranks must be clearly defined, mutually exclusive, and ordered in a hierarchical progression. Further, both types must be able to detect equally both improvement and deterioration. For this to be ensured with the single state scales the population under study must not be clustered at one extreme of the scale at entry into the trial. With the transition scales internal symmetry must be achieved. Strategies for determining the comparisons to be performed should include emphasis on within patient analysis for crossover trials. Concordance between scale scores and the other measures of outcome employed in the trial must be evaluated. Frequent violations were uncovered in the studies reviewed, and it is hoped that the simple rules outlined will prove useful in the planning and evaluation of future trials.
TIP30 inhibits growth of HCC cell lines and inhibits HCC xenografts in mice in combination with 5-FU
Authors: Jian Zhao, Xia Zhang, Mei Shi, Hao Xu, Jun Jin, Haidong Ni, Silei Yang, Jianxin Dai, Mengchao Wu, Yajun Guo
Journal: Hepatology (2006)

Hepatocellular carcinoma (HCC) is an aggressive cancer with a poor prognosis. The specific cellular gene alterations responsible for hepatocarcinogenesis are not well known. Previous works showed that loss of TIP30 , also called CC3 , a putative tumor suppressor, increased the incidence of hepatocellular carcinoma in mice, and some clinical samples of human HCC tissues had aberrant expression of TIP30 . Here, we report that the introduction of TIP30 by an adenovirus vector into HCC cell lines that had decreased expressions of TIP30 inhibited cell proliferation, decreased anchorage-dependent growth, suppressed invasion through the extracellular matrix, and inhibited tumorigenesis in nude mice. Moreover, exogenous expression of Tip30 sensitized HCC cells to cytotoxic drugs and to apoptosis induced by tumor necrosis factor–related ligands in vitro. Ectopic expression of TIP30 in HCC cells enhanced p53 expression and decreased Bcl-2/Bcl-xL expression. Treatment of nude mice bearing subcutaneously established HCC tumors with a combination of an adenovirus expressing TIP30 and the cytotoxic drug 5-fluorouracil completely suppressed tumor growth and prolonged survival. In conclusion , TIP30 may play an important role in the suppression of hepatocarcinogenesis by acting as a tumor suppressor. Overexpression of TIP30 might be a promising candidate as a treatment for HCC that would increase sensitivity to chemotherapeutic drugs. Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html).
Serum lysozyme levels in Crohn's disease and ulcerative colitis.
Authors: T L Peeters, G Vantrappen, K Geboes
Journal: Gut (1976)

Serum lysozyme levels were determined in healthy volunteers, patients with Crohn9s disease, and patients with ulcerative colitis. The mean concentration in Crohn9s disease was significantly greater than in the other groups. In patients with Crohn9s disease, as well as in patients with ulcerative colitis, the lysozyme levels correlated with the severity of the disease process and with the extent of the lesions: the more severe the disease and the more extensive the involvement, the higher the lysozyme levels. However, the lysozyme values of the different groups overlapped considerably. Our results indicate that lysozyme determinations have only limited discriminative value for the diagnosis of Crohn9s disease and for determining the severity and the extent of the disease process in the individual patient.
Letter: Infections in asplenic adults.
Authors: L E Ramsay
Journal: BMJ (1974)

factors, including developmental and genetic, may underlie panacinar emphysema, which sometimes affects coal workers and becomes pigmented.Acquired fibrocystic disease, which in coal workers is often heavily pigmented, must also be distinguished from emphysema.On present evidence it is difficult to envisage a primary role for alveolar macrophages in the genesis of emphysema.Even in a,-antitrypsin deficiency, an un- common state in which leucocytic protease activity may be directed against connective tissue, other factor.smay co-operate in the genesis of emrphysema.The occurrence of alveolar fenestrae and capillary damage may merely represent the early stages of secondary non-specific disruption, which when advanced and widespread and possibly complicated by infection renders it difficult to assess the relative significance of the different pathogenetic processes in emphy- sema.-Iam, etc.,
Reply from Authors re: Rodolfo Montironi, Antonio Lopez-Beltran, Liang Cheng, Francesco Montorsi, Marina Scarpelli. Central Prostate Pathology Review: Should It Be Mandatory? Eur Urol 2013;64:199–201
Authors: Dirk Bottke, Glen Kristiansen, Reinhard Golz, Stephan Störkel, Michael Stöckle, Thomas Wiegel
Journal: European Urology (2013)
HTLV-I associated myelopathy in an identical twin
Authors: Masakatsu Motomura, Tatsufumi Nakamura, Kunihiko Nagasato, Kohji Shibayama, Shin-Ichi Kubo, Ichiro Nakasono, Mitsuhiro Tsujihata, Shunrou Sonoda, Shinji Yashiki, Shigenobu Nagataki
Journal: The Lancet (1990)
EARLY FUNCTIONAL STRAIN DIFFERENCES IN PRE-HYPERTROPHIC CARRIERS WITH MUTATIONS IN MYH7 AND MYBPC3 ASSESSED WITH CMR TISSUE TAGGING
Authors: Ahmet Guclu, Jolanda van der Velden, Wessel P. Brouwer, Albert C. van Rossum Tjeerd, None Germans
Journal: Journal of the American College of Cardiology (2013)
Molecular systematics of cytochrome oxidase I and 16S from Neochlamisus leaf beetles and the importance of sampling
Authors: D. J. Funk
Journal: Molecular Biology and Evolution (1999)

If a gene tree is to be judiciously used for inferring the histories of closely related taxa, (1) its topology must be sufficiently resolved and robust that noteworthy phylogenetic patterns can be confidently documented, and (2) sampling of species, populations, and pertinent biological variation must be sufficiently broad that otherwise misleading sources of genetic variation can be detected. These principles are illustrated by the complex gene tree of Neochlamisus leaf beetles that I reconstructed using 90,000 bp of cytochrome oxidase I (COI) and 16S mitochondrial DNA (mtDNA) sequences from over 100 specimens. Cytochrome oxidase I haplotypes varied up to 25.1% within Neochlamisus and up to 11.1% within the gibbosus species group, while exhibiting very low A + T bias for insect mtDNA (63%), low transition saturation, and conservative patterns of amino acid variation. 16S exhibited lower sequence divergences and greater A + T bias and transition saturation than COI, and substitutions were more constrained in stems than in loops. Comparisons with an earlier study of Ophraella leaf beetles highlighted conservative and labile elements of molecular evolution across genes and taxa. Cytochrome oxidase I parsimony and neighbor-joining analyses strongly supported a robust mtDNA genealogy that revealed the monophyly of Neochlamisus and of the gibbosus species group. Phylogeographic relationships suggested that the eastern U.S. gibbosus group derives from southwestern velutinus group ancestors. Haplotypes from individual velutinus group species clustered monophyletically, as expected. However, haplotypes from each of several gibbosus group taxa were polyphyletically distributed, appearing in divergent parts of the tree. 16S provided a less-resolved gibbosus group topology that was congruent with the COI tree and corroborated patterns of mitochondrial polyphyly. By subsampling haplotypes corresponding to particular species, populations, and ecological variants of gibbosus group taxa, I demonstrate that recovered topologies and genetic distances vary egregiously according to sampling regime. This study thus documents the potentially dire consequences of inadequate sampling when inferring the evolutionary history of closely related and mitochondrially polyphyletic taxa.
Hepatitis C virus envelope components alter localization of hepatocyte tight junction-associated proteins and promote occludin retention in the endoplasmic reticulum
Authors: Ignacio Benedicto, Francisca Molina‐Jiménez, Olga Barreiro, Alejandra Maldonado‐Rodríguez, Jesús Prieto, Ricardo Moreno‐Otero, Rafael Aldabe, Manuel López‐Cabrera, Pedro L. Majano
Journal: Hepatology (2008)

Hepatocyte tight junctions (TJ) play key roles in characteristic liver functions, including bile formation and secretion. Infection by hepatitis C virus (HCV) may cause alterations of the liver architecture and disruption of the bile duct, which ultimately can lead to cholestasis. Herein, we employed the HCV replicon system to analyze the effect of HCV on TJ organization. TJ-associated proteins occludin, claudin-1, and Zonula Occludens protein-1 (ZO-1) disappeared from their normal localization at the border of adjacent cells in Huh7 clones harboring genomic but not subgenomic replicons expressing only the nonstructural proteins. Furthermore, cells containing genomic replicons showed a cytoplasmic accumulation of occludin in the endoplasmic reticulum (ER). TJ-associated function, measured as FITC-dextran paracellular permeability, of genomic replicon-containing cells, was also altered. Interestingly, clearance of the HCV replicon by interferon-α (IFN-α) treatment and by short hairpin RNA (shRNA) significantly restored the localization of TJ-associated proteins. Transient expression of all HCV structural proteins, but not core protein alone, altered the localization of TJ-associated proteins in Huh7 cells and in clones with subgenomic replicons. Confocal analysis showed that accumulation of occludin in the ER partially co-localized with HCV envelope glycoprotein E2. E2/occludin association was further confirmed by co-immunoprecipitation and pull-down assays. Additionally, using a cell culture model of HCV infection, we observed the cytoplasmic dot-like accumulation of occludin in infected Huh7 cells. Conclusion: We propose that HCV structural proteins, most likely those of the viral envelope, promote alterations of TJ-associated proteins, which may provide new insights for HCV-related pathogenesis. (HEPATOLOGY 2008.)
Circulatory Effects of Trumpet Playing
Authors: M. Faulkner, E. P. Sharpey-Schafer
Journal: BMJ (1959)

BUrrA 685Of the patients receiving less than 6 mg. a day, only three suffered any discomfort, and it is suggested that this is the highest maintenance dose which can be prolonged.We thank Dr. M. E. Fearnley, Consultant to the Physical Medicine Department, Orpington Hospital, Kent, for being allowed to report on his patients, and the pharmacists at both hospitals for obtaining supplies in the early stages.
Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection
Authors: Stephen A. Beers, Ruth R. French, H. T. Claude Chan, Sean H. Lim, Timothy C. Jarrett, Regina Mora Vidal, Sahan S. Wijayaweera, Sandra V. Dixon, Hyungjin Kim, Kerry L. Cox, Jonathan P. Kerr, David A. Johnston, Peter W. M. Johnson, J. Sjef Verbeek, Martin J. Glennie, Mark S. Cragg
Journal: Blood (2010)
Pay-for-Performance and Accountability
Authors: John W. Rowe
Journal: Annals of Internal Medicine (2007)

Letters5 June 2007Pay-for-Performance and AccountabilityJohn W. Rowe, MDJohn W. Rowe, MDFrom Columbia University, New York, NY 10032.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-11-200706050-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:In my paper, I indicated that the recertification databases developed by certifying boards may be of limited use for pay-for-performance programs “some certification programs measure performance at 10-year intervals.” I appreciate Dr. Cassel's note that the ABIM's MOC program affords physicians the opportunity to assess their clinical performance regularly throughout a 10-year recertification period. If the recent trend for health plans to recognize these assessments in their reward programs spreads more widely and many more physicians participate, my skepticism in this regard may prove unfounded.I concur with Dr. Sinsky's view regarding the gulf between promise and practice ... Author, Article, and Disclosure InformationAffiliations: From Columbia University, New York, NY 10032.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPay-for-Performance and Accountability: Related Themes in Improving Health Care John W. Rowe Pay-for-Performance and Accountability Christine K. Cassel Pay-for-Performance and Accountability Christine A. Sinsky Pay-for-Performance and Accountability Mahesh Krishnamurthy Pay-for-Performance and Accountability Marcy Zwelling Metrics 5 June 2007Volume 146, Issue 11Page: 824-825KeywordsConflicts of interestDatabasesHealth information technologySurgeonsVeteran care ePublished: 5 June 2007 Issue Published: 5 June 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Diagnosis of Venous Angiosarcoma by FDG PET/CT
Authors: Eugene Lin
Journal: Clinical Nuclear Medicine (2008)

A 56-year-old man with diffuse large cell lymphoma underwent posttherapy F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT). A new focus of intense uptake was detected in contact with the left external iliac vein. This was biopsied and diagnosed as an angiosarcoma of the external iliac vein.
Transjugular intrahepatic portosystemic shunt compared with endoscopic treatment for prevention of variceal rebleeding: A meta-analysis
Authors: George V. Papatheodoridis, John Goulis, Gioacchino Leandro, David Patch, Andrew K. Burroughs
Journal: Hepatology (1999)

Endoscopic treatment (ET) is frequently used to prevent variceal rebleeding but this still occurs in about 50% of patients. Recently, transjugular intrahepatic portosystemic shunt (TIPS) has been compared with ET in several trials. Using a meta-analysis, we evaluated randomized trials comparing TIPS to ET assessing prevention of rebleeding, survival, and the effects on resource use and the quality of patients' lives. Medical databases were searched between January 1988 and January 1999 as well as published citations and conference proceedings. Sensitivity analyses for type of publication, methodological quality score, mean duration of follow-up, type of ET, etiology, and severity of liver disease were performed. Eleven randomized trials involving 811 patients fulfilled the selection criteria. The median follow-up ranged from 10 to 32 months. Variceal rebleeding was significantly more frequent with ET (47%) compared with TIPS (19%) (odds ratio [OR], 3.8; 95% confidence interval [CI], 2.8-5.2; P <.001), but there was no difference in mortality (OR, 0.97; 95% CI, 0.71-1.34). Post-treatment encephalopathy occurred significantly less often after ET (19%) than after TIPS (34%) (OR, 0.43; 95% CI, 0.30-0.60; P <.001). In the studies showing resource use this was more extensive for TIPS. The sensitivity analyses did not alter the main conclusion, and sole comparison with endoscopic ligation did not alter these results. In conclusion, in patients with variceal bleeding, TIPS compared with ET reduces the rebleeding rate, but does not improve survival, and increases the incidence of encephalopathy in a period of 1 to 2.5 years. Thus, TIPS cannot be recommended as the first choice treatment for prevention of variceal rebleeding.
Systematic Understanding of Cancer Patients Who Refuse Treatment
Authors: Richard J. Goldberg
Journal: Psychotherapy and Psychosomatics (1983)

The refusal of treatment by cancer patients often takes place in a highly charged emotional context. Clinicians facing these situations frequently feel they are confronting an ethical dilemma involving whether to accept the patient's refusal or persuade the patient to a different position. However, most situations involving refusal of treatment involve issues of psychological distortions, interpersonal dysfunction, medical systems dysfunction, or psychiatric disorder, such as depression or organic mental disorder. By systematically reviewing these dimensions with the patient, many apparent dilemmas involving refusal of treatment will be resolved.
Detection of Pulmonary Metastases in a Patient with Synovial Cell Sarcoma Using ln-111 Labeled Monoclonal Antibody 19-24
Authors: JOHN E. SWIFT, MICHAEL J. BLEND, CARLOS BEKERMAN, TAPAS K. DAS GUPTA, JOHN A. GREAGER
Journal: Clinical Nuclear Medicine (1990)

A 35-year-old man was diagnosed in 1984 as having a synovial cell sarcoma of his right wrist without evidence of metastatic spread. The patient underwent regional hyperthermic chemoperfusion, wide-field excision, postoperative radiation therapy and systemic adjuvant chemotherapy. In 1986 and in 1987, because of new lesions found on chest radiographs, the patient underwent bilateral staging thoracotomies with resection of pulmonary metastases, followed by chemotherapy and radiotherapy. Later in 1987, a chest radiograph showed a large left hilar mass and multiple bilateral pulmonary nodules. Computerized tomography of the chest demonstrated a left hilar mass and two nodules in the right lower lung, raising the possibility of recurrent pulmonary metastatic cancer. As a diagnostic procedure, ln-111 labeled monoclonal antibody (Mab) 19-24, produced against a human malignant fibrous histiocytoma, was infused intravenously, and 48-hour images revealed focal areas of increased uptake corresponding to the lesions seen on CT. At surgery, the lesions were confirmed to be synovial cell sarcoma. Imaging with Mabs specific for sarcoma may be particularly useful in sarcoma patients in whom there is clinical uncertainty regarding the nature of pulmonary lesions. In this case, the Mab was useful in distinguishing tumor deposits from postsurgical scarring and helped to guide subsequent surgery and treatment.
Crystals, joints, and consternation.
Authors: D McCarty
Journal: Annals of the Rheumatic Diseases (1983)

I have often imagined that nature is covered over with knitted material. If a loose thread can be located and pulled, one can see some of the underlying picture. With a bit of luck (and a research grant) one can, with the help of one9s colleagues, continue to unravel the weave, row after row. Although none of us will live to see all of the picture, not even of a single disease, we may see enough of the process to intervene effectively. Control of uric acid metabolism has already conquered the gout and provides inspiration. Whether control of abnormal calcium crystal deposition will prevent the inflammatory and degenerative arthritides with which such deposition seems to be associated remains a source of consternation.
Building the Healing Partnership: Parents, Professionals, and Children With Chronic Illnesses and Disabilities
Authors: Morris Green
Journal: JAMA (1993)

Recent years have witnessed increased attention to family-centered and community-based care of children with chronic illness or disability and their families. The professional skills and the partnership between care givers and parents that the optimal care of these children requires differ from those needed in acute illness. Curing is the predominant goal in the latter, caring in the former. The latter is well established, the former underdeveloped.  This timely book is an important addition to our cumulative knowledge in a developing aspect of health care that belatedly is receiving greater visibility and attention. In providing practical, specific approaches and recommendations for both parents and practitioners, it impressively fulfills a widespread need of both professionals and parents for expert guidance and tutoring in a challenging health care arena.  This goal is not accomplished through a simplistic cookbook format. Rather, the authors' creative approach of interspersing thoughtful commentaries with salient, concise, illustrative
Post-partum Haemorrhage
Authors: H. E. Reiss
Journal: BMJ (1955)

The neurological mouse mutant strain <i>reeler</i> displays abnormal laminar organization of several brain structures as a consequence of a defect in cell migration during neurodevelopment. This phenotype is a result of the disruption of <i>reelin</i>, a gene encoding a protein that has several structural characteristics of extracellular matrix proteins. To understand the molecular basis of the action of Reelin on neuronal migration, we constructed a full-length<i>reelin</i> clone and used it to direct Reelin expression. Here, we demonstrate that Reelin is a secreted glycoprotein and that a highly charged C-terminal region is essential for secretion. In addition, we demonstrate that an amino acid sequence present in the N-terminal region of Reelin contains an epitope that is recognized by the CR-50 monoclonal antibody. CR-50 was raised against an antigen expressed in normal mouse brain that is absent in <i>reeler</i>mice. The interaction of CR-50 with its epitope leads to the disruption of neural cell aggregation <i>in vitro</i>. Here, we used CR-50 to precipitate Reelin from reticulocyte extracts programmed with<i>reelin</i> mRNA, from cells transfected with<i>reelin</i> clones, and from cerebellar explants. The<i>reelin</i> gene product seems to function as an instructive signal in the regulation of neuronal migration.