Therapy for Multifactorial Hypertension
Authors: Robert C. Tarazi
Journal: Annals of Internal Medicine (1978)

Editorials1 May 1978Therapy for Multifactorial HypertensionROBERT C. TARAZI, M.D., F.A.C.P.ROBERT C. TARAZI, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-5-705 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe distance from therapeutic nihilism to aggressive mobilization of socioeconomic resources against hypertension has been covered in only a few years. It was not long ago that some were still arguing that hypertension might be a compensatory mechanism and better left untouched. We have come a long way, but we should not forget how we came lest we go from one excess into another.Of the many concepts that evolved from the extensive work in hypertension, few have proved as durable or productive as the mosaic theory of Page (1, 2). The complex of hemodynamic, humoral, volume, and neurogenic factors...References1. PAGE I: The pathogenesis of arterial hypertension. JAMA 140:451, 1949 CrossrefMedlineGoogle Scholar2. TARAZI R: The mosaic theory, reality or myth? in Pathophysiology and Management of Arterial Hypertension, edited by BERGLUND G, HANSSON L, WERKO L. Sweden, Lindgren & Soner, 1975, pp. 127-150 Google Scholar3. TARAZI R: Method for treatment of hypertension, in Current Therapy 1977, edited by CONN H. Philadelphia, W.B. Saunders Co., 1977, pp. 205-221 Google Scholar4. Executive Summary of the Task Force Reports to the Hypertension Information and Education Advisory Committee. National High Blood Pressure Education Program, Bethesda, National Institutes of Health, 1973, pp. 1-20 Google Scholar5. DUSTAN H: Evaluation and therapy of hypertension—1976. Mod Concepts Cardiovasc Dis 45:97-103, 1976 MedlineGoogle Scholar6. GIFFORD R and TARAZI R: Resistant hypertension: diagnosis and management. Ann Intern Med 88:661-665, 1978 LinkGoogle Scholar7. LARAGH J: Vasoconstriction-volume analysis for understanding and treating hypertension: the use of renin and aldosterone profiles. Am J Med 55:261-274, 1973 CrossrefMedlineGoogle Scholar8. TARAZI R: Hemodynamic role of extracellular fluid in hypertension. Circ Res 38(suppl II):II-72-83, 1976 Google Scholar9. DUSTAN H, TARAZI R, and BRAVO E: Diuretic and diet treatment of hypertension. Arch Intern Med 133:1007-1013, 1974 CrossrefMedlineGoogle Scholar10. FROHLICH E: Concepts of pressor mechanisms in hypertension evolved through clinical experience with beta-adrenergic receptor blocking drugs. Ann NY Acad Sci, in press, 1978 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT C. TARAZI, M.D., F.A.C.P.Affiliations: Research Division The Cleveland Clinic Foundation Cleveland, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTotal Peripheral Resistance and Beta-Adrenergic BlockadeLate Resistance to CaptoprilHemodynamics of a new angiotensin antagonist, [Sar1, Thr8]A II, in hypertensive man. 1 May 1978Volume 88, Issue 5Page: 705-706KeywordsHemodynamicsHypertension ePublished: 1 December 2008 Issue Published: 1 May 1978 PDF downloadLoading ...