Human Metapneumovirus: Important but Not Currently Diagnosable
Authors: Jo-Anne H. van Burik
Journal: Annals of Internal Medicine (2006)

Editorials7 March 2006Human Metapneumovirus: Important but Not Currently DiagnosableJo-Anne H. van Burik, MDJo-Anne H. van Burik, MDFrom University of Minnesota, Minneapolis, MN 55455.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-5-200603070-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In 2001, van den Hoogen and colleagues (1) isolated human metapneumovirus (hMPV) from 28 children by using nasopharyngeal samples collected over 20 years. Human metapneumovirus was invisible before 2001, in part because the virus did not infect standard cell lines used to isolate respiratory virus pathogens. Five years later, we have a flurry of research activity as investigators try to establish the clinical significance of this paramyxovirus. In this editorial, I will describe the virus and its clinical effects and then address 2 relevant clinical questions: whom to test for infection and which diagnostic test to use.Human metapneumovirus has ...References1. van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7:719-24. [PMID: 11385510] CrossrefMedlineGoogle Scholar2. Kuiken T, van den Hoogen BG, van Riel DA, Laman JD, van Amerongen G, Sprong L, et al. Experimental human metapneumovirus infection of cynomolgus macaques (Macaca fascicularis) results in virus replication in ciliated epithelial cells and pneumocytes with associated lesions throughout the respiratory tract. Am J Pathol. 2004;164:1893-900. [PMID: 15161626] CrossrefMedlineGoogle Scholar3. Williams JV, Harris PA, Tollefson SJ, Halburnt-Rush LL, Pingsterhaus JM, Edwards KM, et al. 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[PMID: 15847919] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Minnesota, Minneapolis, MN 55455.Grant Support: None.Disclosures: None disclosed.Corresponding Author: Jo-Anne H. van Burik, MD, MMC 250, 420 Delaware Street SE, Minneapolis, MN 55455; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBrief Communication: Fatal Human Metapneumovirus Infection in Stem-Cell Transplant Recipients Janet A. Englund , Michael Boeckh , Jane Kuypers , W. Garrett Nichols , Robert C. Hackman , Rhoda A. Morrow , David N. Fredricks , and Lawrence Corey Metrics Cited ByPreventive Effect of Protein-Energy Supplementation on the Functional Decline of Frail Older Adults With Low Socioeconomic Status: A Community-Based Randomized Controlled StudyCOMPARISON OF HUMAN METAPNEUMOVIRUS INFECTION WITH RESPIRATORY SYNCYTIAL VIRUS INFECTION IN CHILDRENClinical disease and viral load in children infected with respiratory syncytial virus or human metapneumovirus 7 March 2006Volume 144, Issue 5Page: 374-375KeywordsCell culturesElderlyHuman metapneumovirus infectionInfantsLung transplantationNucleic acidsPopulation statisticsRNA virusesRespiratory failureUpper respiratory tract infections ePublished: 7 March 2006 Issue Published: 7 March 2006 CopyrightCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...