tbuckley/cabot-search huggingface dataset:
Outcomes After Acute Myocardial Infarction in South Asian, Chinese, and White Patients
Authors: Nadia A. Khan, Maja Grubisic, Brenda Hemmelgarn, Karen Humphries, Kathryn M. King, Hude Quan
Journal: Circulation (2010)

Cardiac mortality rates vary substantially between countries and ethnic groups. It is unclear, however, whether South Asian, Chinese, and white populations have a variable prognosis after acute myocardial infarction (AMI). To clarify this association, we compared mortality, use of revascularization procedures, and risk of recurrent AMI and hospitalization for heart failure between these ethnic groups in a universal-access healthcare system.We used a population cohort study design using hospital administrative data linked to cardiac procedure registries from British Columbia and the Calgary Health Region Area in Alberta (1994 to 2003) to identify AMI cases. Patient ethnicity was categorized using validated surname algorithms. There were 2190 South Asian, 946 Chinese, and 38479 white patients with AMI identified. There was no significant difference in use of revascularization procedures between ethnic groups at 30 d and 1 year. Short-term (30-day) mortality was higher among Chinese relative to white patients (odds ratio, 1.23; 95% confidence interval, 1.02 to 1.48). There was no significant difference in 30-day mortality between South Asian and white patients. South Asian patients had a 35% lower relative risk of long-term mortality compared with white patients (hazard ratio, 0.65; 95% confidence interval, 0.57 to 0.72). There was no significant difference in long-term mortality between Chinese and white patients. Among AMI survivors, Chinese patients had a lower risk of recurrent AMI, whereas there was no difference between South Asian and white patients.The ethnic groups studied have striking differences in outcomes after AMI, with South Asian patients having significantly lower long-term mortality after AMI.
"AN UNUSUALLY LARGE GALLSTONE"
Authors: Howard Jones
Journal: JAMA (1925)

To the Editor:  —InThe Journal, Dec. 20, 1924, Dr. A. J. Gordon, Newark, N. J., under the title An Unusually Large Gallstone Passed by Rectum gives the weight and dimensions of an unusually large stone removed by Nature's surgery. Many years ago, a woman, aged 68, who was a patient of my father, had many attacks of jaundice with pain; and, finally, following an attack, passed by rectum a gallstone of the following weight and dimensions: weight, 4 drams and 27 grains (17.25 gm.); long circumference, 5¼ inches (133 mm.); circumference at right angles to its length, 31/16 inches (78 mm.), at largest part; length, 2½ inches (63 mm.). The patient made a good recovery, and lived to be over 90 years. I have the stone and a photograph of it.
Stop drug secrecy, says government watchdog
Authors: A Tonks
Journal: BMJ (1994)

The British government must take the lead in ending the secrecy surrounding the manufacture, licensing, and marketing of new drugs in Europe, says the National Consumer Council in a report published last week. According to the council, patients are denied access to detailed information on safety, quality, and efficacy of new drugs to protect drug companies from revealing trade secrets to their rivals.

Under a new European drugs regulating system, to be launched next year, drugs approved by the licensing agency in one country will be fast …
Technique of Coughing
Authors: Richard J. Powers
Journal: JAMA (1978)

<h3>To the Editor.—</h3> I am subject to attacks of allergic asthma complicated by bronchitis. I discovered a technique for coughing that has served me well in clearing large numbers of mucus plugs. The technique consists of exhaling as completely as possible (really forcing the air out), coughing hard a couple of times (with all the air completely expelled), taking in a small amount of air, coughing again a couple of times, taking in a little more air, coughing again, taking in still more air, coughing again, and so on, until I was taking in large amounts of air and coughing in the usual way. As I was doing this, I could feel the secretions moving up my bronchi and being coughed out. This technique may already be described or be in widespread use, but I have never heard of it.
Human Papillomavirus Lesions of the Oral Cavity
Authors: Eric T Stoopler, Ramesh Balasubramaniam
Journal: New England Journal of Medicine (2011)

A 49-year-old man who was HIV-positive and had type 2 diabetes presented with multiple papillary lesions in his mouth and throat. The lesions, which had developed 10 years earlier and had increased in size and number, had been evaluated but not diagnosed or treated.
First a Dream: The History of Boston's Jewish Hospitals, 1896 to 1928
Authors: Lester S. King
Journal: JAMA (1991)

Traditionally, hospitals began as a means of caring for the sick poor. Today, in contrast, the hospital is the center of medical practice, education, and research. The transformation, a relatively recent phenomenon, started to gain momentum around the turn of the century. In the present publication Dr Linenthal examines the early stages of this movement. The book deals with the Jewish community in Boston over a period of about 30 years, ending in 1928. Holding center stage are the problems that arose from massive immigration, with attendant poverty, complicated by an alien culture and a language barrier. How to care for the sick poor under such circumstances? By sharply focusing his approach— the Jewish hospitals in Boston over three crucial decades—the author has made a truly superb contribution on the progress of medicine, the growth of hos pitals, and the sociological interactions— what I would call the dynamics of medicine.
Prospective Clinical Trial Evaluating the Efficacy of Photodynamic Therapy for Symptomatic Circumscribed Choroidal Hemangioma
Authors: Anna Boixadera, José García Arumí, Vicente Martínez-Castillo, Jose Luis Encinas, Javier Elizalde, Gonzalo Blanco-Mateos, Jose Caminal, Carmela Capeans, Félix Armada, Amaparo Navea, Jose Luis Olea
Journal: Ophthalmology (2008)
Helping Troubled Children
Authors: Leon Tec
Journal: JAMA (1977)

I disagree with the author when he says that this book is meant for nonpsychiatric professionals. I find that the clarity of thinking and ability to express ideas in simple everyday language is a skill that every child psychiatrist should try to develop and maintain. However, most of the readers of this journal are physicians of various specialties, and if they are interested in knowing more about troubled children, they surely will learn a lot from this volume. Rutter is a master in his ability to convey complex thoughts in a readable manner easily followed. Despite the fact that some may disagree with his concept of schizophrenia occurring only later in childhood, what comes through is a tolerant and nondogmatic approach. It is rewarding to see that the author did not neglect to speak about temperamental attributes. A child's temperament and character have an important association with future development of
CONCERNING THE RELATIVE RESPONSE TO BLOOD GAINS AND BLOOD LOSSES; AND HABITUATION TO AN EXCESS OF BLOOD PIGMENT
Authors: Macdonald Dick
Journal: The Journal of Experimental Medicine (1933)

The effects of very gradually increasing or diminishing the amount of circulating hemoglobin have been studied in rabbits. Contrary to expectation it was found that when the pigment was increased by the injection of a small quantity of compatible blood every day during some weeks the erythropoietic tissue did not lessen its activities. The hemoglobin percentage mounted gradually yet considerably when even as little as 1/100 of the amount of blood initially possessed by the animal was injected each day; and the figure it finally attained must in some instances at least have been expressive of a superabundance. To this superabundance the animal itself evidently contributed through its persisting erythropoietic activity. The results were very different when rabbits were bled daily to the same small amount that was injected into their fellows. The marrow became abnormally active, and this activity continued undiminished throughout the long period of the bleedings. The organism is evidently far more susceptible to blood losses than to blood gains, a fact which is scarcely surprising when one considers that throughout its differentiation as a going concern it has had to cope with exigencies of the first sort only. Rabbits in which the hemoglobin is very gradually increased by the injection of strange blood become so accustomed to the abundance of pigment that even a slight falling off causes the erythropoietic tissue to become abnormally active to maintain the new status quo. Good reasons exist for referring the habituation thus manifested to readjustments in the functioning of the physiological mechanisms which mediate between oxygen demand and erythropoietic response. Too little recognition has been given to the rôle of these mechanisms in such relation. No evidence was obtained of any effective readjustment to protect the erythropoietic tissue from the stimulus of daily small blood losses.
IN WHAT CASES AND WHEN TO ENUCLEATE IN INJURIES OF THE EYE.
Authors: JOHN M. FOSTER
Journal: JAMA (1898)

There is probably no class of cases that fall to our care that give us the same amount of anxiety and solicitude as to the probable and possible outcome, as that which occurs in the injuries, especially in the penetrating wounds, of the eye. The experience of years and a large number of cases does not enable us to say with any degree of precision, this case will have sympathetic ophthalmia, or panophthalmitis, or that that case will not. We know that in a certain class of accidents, especially in those where there has been deep, penetrating wounds, more particularly in the ciliary region, serious results are liable to follow, and they often do. But, on the other hand, how frequently we note the termination of these unfavorably appearing cases in kindly healing, without the slightest untoward symptom; no irritation of the fellow eye, and even a better result in
Abnormal TNF activity in Timp3−/− mice leads to chronic hepatic inflammation and failure of liver regeneration
Authors: Fazilat F Mohammed, David S Smookler, Suzanne E M Taylor, Barbara Fingleton, Zamaneh Kassiri, Otto H Sanchez, Jane L English, Lynn M Matrisian, Billie Au, Wen-Chen Yeh, Rama Khokha
Journal: Nature Genetics (2004)
Creatinine Clearance: Bedside Estimate
Authors: ROGER W. JELLIFFE
Journal: Annals of Internal Medicine (1973)

Letters1 October 1973Creatinine Clearance: Bedside EstimateROGER W. JELLIFFE, M.D.ROGER W. JELLIFFE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-4-604 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Previously described computer programs have shown their ability to estimate endogenous creatinine clearance (Ccr) with reasonable accuracy when urine specimens cannot be obtained to calculate endogenous creatinine clearance in the standard manner (1). Such estimates have been very useful for planning drug dosage regimens for patients (2, 3) : they have been based on stable or changing serum creatinine levels, age, sex, height, and weight.When the serum creatinine level is stable, however, and the patient is an adult from 20 to 80 years old, a bedside estimate that closely approaches those of the computer programs may...References1. JELLIFFEJELLIFFE RS: A computer program for estimation of creatinine clearance from unstable serum creatinine levels, age, sex, and weight. Mathematical Biosciences 14:17-24, 1972 CrossrefGoogle Scholar2. JELLIFFE R: New developments in drug dosage regimens. Journal Mondiat de Pharmacie 15:53-78, 1972 Google Scholar3. JELLIFFEBUELLKALABA RJR: Reduction of digitalis toxicity by computer-assisted glycoside dosage regimens. Ann Intern Med 77:891-906, 1972 LinkGoogle Scholar4. SIERSBAEK-NIELSENMOLHOLM HANSENKAMPMAN KJJ: Rapid evaluation of creatinine clearance. Lancet 1:1133-1134, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROGER W. JELLIFFE, M.D.Affiliations: University of Southern California School of Medicine Los Angeles, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEstimating Equations for Glomerular Filtration Rate in the Era of Creatinine Standardization A Systematic ReviewAmy Earley, BS, Dana Miskulin, MD, MS, Edmund J. Lamb, PhD, Andrew S. Levey, MD, and Katrin Uhlig, MD, MSA More Accurate Method To Estimate Glomerular Filtration Rate from Serum Creatinine: A New Prediction EquationAndrew S. Levey, MD, Juan P. Bosch, MD, Julia Breyer Lewis, MD, Tom Greene, PhD, Nancy Rogers, MS, and David Roth, MD, for the Modification of Diet in Renal Disease Study Group*Predicted Creatinine ClearanceTOBIAS L. YEH, PHARM.D., RAYMOND D. SILKAITIS, PH. D.Creatinine Clearance and AgeREED E. PYERITZ, M.D., PH.D.Estimation of Creatinine ClearanceMICHAEL D. ROBSON, M.R.C.P. 1 October 1973Volume 79, Issue 4Page: 604-605KeywordsCreatinineSoftware tools ePublished: 13 March 2020 Issue Published: 1 October 1973 PDF downloadLoading ...
Abstract 3337: LRIG1 decreases cell proliferation and motility through downregulation of ErbB2 611-CTF
Authors: Maria E. Cedano-Prieto
Journal: Cancer Research (2014)

Abstract The receptor ErbB2 is a membrane bound protein that controls important cell functions including cell cycle progression; deregulated expression of this protein is associated with the development of a variety of cancer types. Notably, ErbB2 over-expression is observed in approximately 25% of human breast tumors. Trastuzumab, an FDA approved therapeutic currently used to treat ErbB2 positive breast cancer patients, is a monoclonal antibody that directly binds the ErbB2 extracellular domain. Unfortunately, only a fraction of patients treated with trastuzumab durably respond to the treatment. Moreover, patients that are treated long term with this antibody develop resistance. One of the proposed mechanisms of trastuzumab resistance is the expression of 611-CTF, a C-terminal fragment of ErbB2 which lacks most of its extracellular domain. Remarkably, 611-CTF is hyperactive and has been associated with increased cell migration, tumor progression and metastasis. Currently nothing is known regarding mechanisms which lead to 611-CTF down-regulation. This represents a significant knowledge gap in our understanding of 611-CTF and receptor fragments in general. Since 611-CTF is associated with poor clinical outcome and therapeutic resistance, it is essential to clarify the mechanisms by which this ErbB2 fragment is regulated. This knowledge could ultimately lead to the development of new therapeutics which could improve the response rate of 611-CTF-positive breast cancer. LRIG1 is a tumor suppressor that directly interacts with ErbB2 leading to receptor degradation. In this study we examined whether 611-CTF is susceptible to LRIG1-mediated down-regulation. We find that these proteins interact and that expression of LRIG1 is sufficient to decrease 611-CTF protein expression in three different cell lines. Furthermore, LRIG1 is capable of reducing 611-CTF-driven tumor cell proliferation and migration. Our results are unexpected because LRIG1 is thought to recognize its targets through mutual extracellular domain interactions and 611-CTF lacks a large portion of the ErbB2 extracellular domain. Citation Format: Maria E. Cedano-Prieto. LRIG1 decreases cell proliferation and motility through downregulation of ErbB2 611-CTF. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3337. doi:10.1158/1538-7445.AM2014-3337
The Beginning of Health Care Reform: The Clinton Plan
Authors: Marcia Angell
Journal: New England Journal of Medicine (1993)

On September 22 President Clinton described his American Health Security Act of 1993 to the nation in a long-awaited speech before the joint houses of Congress. The speech marked the end of seven months of intense activity by Hillary Rodham Clinton's task force to devise the plan and the beginning of the political process of implementing it. It will probably take the better part of a year before a bill actually makes it through Congress, and the bill will almost certainly differ from the Clintons' plan. Elsewhere in this issue, John Iglehart, our national correspondent, describes the tortuous process of . . .
Three Cases of Friedreich's Disease All Presenting Marked Increase of the Knee-Jerk
Authors: G. Hodge
Journal: BMJ (1897)

Txx BaTIErO 1405 supplement them, and thus from the sum of the experience of many this important question may be decided.If, as my limited experience seems to indicate, antitoxin by inoculation 1has the power of preventing infection, then assuredly has this disease been robbed of much of its terror.
TCT-574 Comparison of everolimus-eluting stents with first (paclitaxel, sirolimus) and second-generation (zotarolimus, biolimus) drug-eluting stents in patients with acute coronary syndromes [Katowice-Zabrze Registry on first and second generation DES]
Authors: Damian Kawecki, Wojciech M. Wanha, Beata Morawiec, Janusz Dola, Aleksandra Pluta, Kamil Marcinkiewicz, Tomasz Roleder, Grzegorz A. Smolka, Andrzej J. Ochala, Michal Tendera, Wojciech Wojakowski
Journal: Journal of the American College of Cardiology (2014)
Anticoagulant-Induced Hemopericardium with Tamponade
Authors: Stanley C. Fell, Ira L. Rubin, Charles D. Enselberg, Elliott S. Hurwitt
Journal: New England Journal of Medicine (1965)

NONTRAUMATIC hemopericardium with tamponade usually occurs as a preterminal event in cases of myocardial infarction or dissecting aortic aneurysm.1 Clinically significant hemopericardium is an uncommon but well documented complication of anticoagulant therapy2; it has been reported only in association with myocardial infarction3 , 4 or pericarditis, either traumatic5 or nonspecific.6 , 7 The purpose of this communication is to present 2 cases of spontaneous hemopericardium with tamponade, unassociated with myocardial necrosis or pericarditis, induced by anticoagulant therapy. One case, undiagnosed, terminated fatally; the other patient survived after pericardiectomy.Case ReportsCase 1. A 40-year-old man (M.H. 103787) was admitted to Montefiore Hospital for . . .
Clinical Cardiology: Current Practice GuidelinesKatritsisDemosthenes G.GershBernard J.CammA. John, eds. 1171 pages. Oxford, UK: Oxford University Press, 2013. ISBN-10: 0521867126. ISBN-13: 978-0521867122. 230 pages. $115.00. ISBN: 978-0-19-968528-8
Authors: Walter J. Paulus
Journal: Circulation (2014)
The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A
Authors: Matthew J. Flick, Anil K. Chauhan, Malinda Frederick, Kathryn E. Talmage, Keith W. Kombrinck, Whitney Miller, Eric S. Mullins, Joseph S. Palumbo, Xunzhen Zheng, Naomi L. Esmon, Charles T. Esmon, Sherry Thornton, Ann Becker, Leslie A. Pelc, Enrico Di Cera, Denisa D. Wagner, Jay L. Degen
Journal: Blood (2011)
A Polymorphism of a Platelet Glycoprotein Receptor as an Inherited Risk Factor for Coronary Thrombosis
Authors: Ethan J. Weiss, Paul F. Bray, Matthew Tayback, Steven P. Schulman, Thomas S. Kickler, Lewis C. Becker, James L. Weiss, Gary Gerstenblith, Pascal J. Goldschmidt-Clermont
Journal: New England Journal of Medicine (1996)

Platelet glycoprotein IIb/IIIa is a membrane receptor for fibrinogen and von Willebrand factor, and it has an important role in platelet aggregation. It is known to be involved in the pathogenesis of acute coronary syndromes. Previously, we found a high frequency of a particular polymorphism, Pl A2 , of the gene encoding glycoprotein IIIa in kindreds with a high prevalence of premature myocardial infarction.
Double-Contrast Barium Meal and Upper Gastrointestinal Endoscopy
Authors: CORNELIUS P. DOOLEY
Journal: Annals of Internal Medicine (1984)

One hundred randomly selected inpatients were examined with both double-contrast barium meal and endoscopy in a blinded prospective fashion. All studies were done by staff personnel, with equal clinical information available to both the radiologist and endoscopist. The final diagnosis was made by a review committee of participating radiologists and endoscopists. Endoscopy was more sensitive (92% versus 54%, p < 0.001) and specific (100% versus 91%, p < 0.05) than the double-contrast barium meal. Both procedures significantly affected the clinical outcome of the patient, the effect of endoscopy being significantly greater than that of the double-contrast barium meal. Although errors with the barium study related predominantly to an inability to show subtle lesions, poor patient cooperation and perceptual and technical failures were additional significant factors. Endoscopy is recommended for certain groups of patients.
Abstract 1381: The effect of proteasome inhibitor velcade on tumor microenvironment
Authors: Fuqiu He, Xiaorong Sun, E Ackerstaff, Ligang Xing, Akiko Minami, Hung Tsung Hsiao, Sean Carlin, Clifton C. Ling, Jason Koutcher, Gloria C. Li
Journal: Cancer Research (2010)

Abstract It has been reported that the therapeutic effect of the proteasome inhibitor Velcade is due to its selective interference in the hypoxia pathway. We studied the effect of Velcade on tumor microenvironment and examined the underlying molecular mechanisms. We have generated a human colorectal cancer xenograft model (#C53) in which the hypoxia-inducible dual reporter fusion gene (HSV1-TK and eGFP) was under the control of hypoxia-response-element (HRE). In vitro, #C53 cells were treated with Velcade in normoxic and hypoxic conditions, and the following assays were performed in comparison with controls: eGFP (flow cytometry), CA9 (western blot), VEGF (ELISA), and TK activity (trapping of the marker substrate 14C-FIAU). In vivo, #C53 xenografts were treated with Velcade and various assays performed, including a) Dynamic contrast-enhanced (DCE) MRI pre and post treatment; b) dual hypoxia marker (pimonidazole and EF5) administration pre and post treatment; c) fluorescence microscopy of Hoechst 33342 (perfusion), eGFP, HIF-1α, and CA9; and d) plasma VEGF level (ELISA), Where applicable data from control and treated tumors were compared. Our results showed that in both in vitro and in vivo experiments Velcade treatment increased the level of HIF1α, but decreased those of hypoxia-induced eGFP, TK, CA9 and VEGF. Interestingly, in the dual hypoxia marker study there were significant EF5-positive regions that did not co-localize with pimonidazole-positive regions, suggesting de novo hypoxia and perhaps another novel effect of Velcade on tumor microvasculature. Consistent with these results, DCE MRI demonstrated decrease global tumor blood flow with Velcade treatment. Our data suggest that Velcade suppresses the hypoxia response by disrupting the HIF1 transcriptional activity. In addition, our results suggest a novel function of Velcade in modifying the tumor microenvironment and decreasing tumor perfusion as noninvasively detected by DCE MRI. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1381.