tbuckley/cabot-search huggingface dataset:
The Sex Side of Life: Mary Ware Dennett's Pioneering Battle for Birth Control and Sex Education
Authors: Jane E. Hodgson
Journal: JAMA (1996)

A quick glance at the title might lead one to classify this book as a sexology text, which it is not. Rather, it is a fascinating, poignantly sad biography of a remarkable woman, who was born into an upper middle-class family in 1872 and raised and educated in the Boston area. Until this book, Mary Ware Dennett's life story had been acknowledged by little more than footnotes in women's histories.<sup>1-3</sup> Access to Dennett's archives was recently granted to Constance Chen, a 27-year-old Harvard medical student. The material in the book is extremely well researched and documented by 785 notes presented in the last 30 pages. However, I felt handicapped by the lack of an index, and the writing seemed somewhat stilted at times, and repetitious, eg, Hartley Dennett's many juvenile "cutesy" poems to Mary. But the subject matter was engrossing. The number and importance of the backstage roles
Reduced endothelial secretion and plasma levels of transforming growth factor-β1 in patients with hereditary hemorrhagic telangiectasia type 1
Authors: M LETARTE, M MCDONALD, C LI, K KATHIRKAMATHAMBY, S VERA, N PECEBARBARA, S KUMAR
Journal: Cardiovascular Research (2005)

Objective: To determine if patients with hereditary hemorrhagic telangiectasia (HHT) show alterations in transforming growth factor (TGF)-β and its pathways.
I Am an Internist (A Haiku Cycle)
Authors: Eliot A. Brinton
Journal: Annals of Internal Medicine (1993)

Ad Libitum15 November 1993I Am an Internist (A Haiku Cycle)Eliot A. Brinton, MDEliot A. Brinton, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-10-199311150-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Student of bodyparts unknown notes tests new worldstrod upon spring grass.White coat worn handbookedges fill pockets, tired eyesstroke a fevered brow.Deep probing, patienttrials thrust forward harvestlight shadows of pain.Gray furrows gatheryoung thoughts pointed tales humorcareful paths in snow. Author, Article, and Disclosure InformationAffiliations: Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1993Volume 119, Issue 10Page: 1049KeywordsStroke Issue Published: 15 November 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene
Authors: M.D. Briggs, S.M.G. Hoffman, L.M. King, A.S. Olsen, H. Mohrenweiser, J.G. Leroy, G.R. Mortier, D.L. Rimoin, R.S. Lachman, E.S. Gaines, J.A. Cekleniak, R.G. Knowlton, D.H. Cohn
Journal: Nature Genetics (1995)
Postprandial stimulation of insulin release by glucose-dependent insulinotropic polypeptide (GIP). Effect of a specific glucose-dependent insulinotropic polypeptide receptor antagonist in the rat.
Authors: C C Tseng, T J Kieffer, L A Jarboe, T B Usdin, M M Wolfe
Journal: Journal of Clinical Investigation (1996)

Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid peptide produced by K cells of the mammalian proximal small intestine and is a potent stimulant of insulin release in the presence of hyperglycemia. However, its relative physiological importance as a postprandial insulinotropic agent is unknown. Using LGIPR2 cells stably transfected with rat GIP receptor cDNA, GIP (1-42) stimulation of cyclic adenosine monophosphate (cAMP) production was inhibited in a concentration-dependent manner by GIP (7-30)-NH2. Competition binding assays using stably transfected L293 cells demonstrated an IC50 for GIP receptor binding of 7 nmol/liter for GIP (1-42) and 200 nmol/liter for GIP (7-30)-NH2, whereas glucagonlike peptide-1 (GLP-1) binding to its receptor on ++betaTC3 cells was minimally displaced by GIP (7-30)-NH2. In fasted anesthetized rats, GIP (1-42) stimulated insulin release in a concentration-dependent manner, an effect abolished by the concomitant intraperitoneal administration of GIP (7-30)-NH2 (100 nmol/ kg). In contrast, glucose-, GLP-1-, and arginine-stimulated insulin release were not affected by GIP (7-30)-NH2. In separate experiments, GIP (7-30)-NH2 (100 nmol/kg) reduced postprandial insulin release in conscious rats by 72%. It is concluded that GIP (7-30)-NH2 is a GIP-specific receptor antagonist and that GIP plays a dominant role in mediating postprandial insulin release.
Interleukin 6 Is Required for the Development of Collagen-induced Arthritis
Authors: Tonino Alonzi, Elena Fattori, Domenico Lazzaro, Patrizia Costa, Lesley Probert, George Kollias, Fabrizio De Benedetti, Valeria Poli, Gennaro Ciliberto
Journal: The Journal of Experimental Medicine (1998)

Interleukin-6 (IL-6) is overproduced in the joints of patients with rheumatoid arthritis (RA) and, based on its multiple stimulatory effects on cells of the immune system and on vascular endothelia, osteoclasts, and synovial fibroblasts, is believed to participate in the development and clinical manifestations of this disease. In this study we have analysed the effect of ablating cytokine production in two mouse models of arthritis: collagen-induced arthritis (CIA) in DBA/1J mice and the inflammatory polyarthritis of tumor necrosis factor α (TNF-α) transgenic mice. IL-6 was ablated by intercrossing an IL-6 null mutation into both arthritis-susceptible genetic backgrounds and disease development was monitored by measuring clinical, histological, and biochemical parameters. Two opposite responses were observed; while arthritis in TNF-α transgenic mice was not affected by inactivation of the IL-6 gene, DBA/1J, IL-6−/− mice were completely protected from CIA, accompanied by a reduced antibody response to type II collagen and the absence of inflammatory cells and tissue damage in knee joints. These results are discussed in the light of the present knowledge of cytokine networks in chronic inflammatory disorders and suggest that IL-6 receptor antagonists might be beneficial for the treatment of RA.
Guidelines for the utilisation of intensive care units
Authors: J. L. Vincent, A. Artigas, D. Bihari, R. B. Carrington da Costa, D. Edwards, P. Ferdinande, G. Iapichino, M. Lamy, P. Loirat, D. Miranda, M. Munoz-Sanchez, J. Papadatos, K. Remhart, P. Suter, J. Takala, L. G. Thijs, S. Vesconi, S. Willatts
Journal: Intensive Care Medicine (1994)
WHERE SHALL WE PLACE OUR CADUCEUS EMBLEM?
Authors: James H. Mendel
Journal: JAMA (1924)

<h3>To the Editor:</h3> —The increasing use and recognition of the caduceus as an emblem of the medical profession, and the presence of cold weather, have led me to make a suggestion concerning the proper placing of this distinctive sign on the physician's motor car. As at present supplied by the American Medical Association, the emblem is accompanied by three long metal pins which are to be used in holding it tightly against the radiator. When the temperature hovers around the freezing point and it becomes necessary to employ a so-called winter front or the old fashioned radiator and hood cover, the emblem is entirely hidden. As a rule, when the physician's car is standing in a time limit parking zone, parking rules are stretched a point when this well known symbol is exposed. Some of these cold weather helps cover the whole front of the radiator, blotting out the sign
US and Non-US Submissions
Authors: Ann M. Link
Journal: JAMA (1998)

Context.—Reviewers increasingly are asked to review manuscripts from outside their own country, but whether they are more likely to recommend acceptance of such manuscripts is not known.Objective.—To assess whether US reviewers or non-US reviewers evaluate manuscripts differently, depending on whether the manuscripts are submitted from outside the United States or from the United States.Design and Setting.—A retrospective analysis of all original submissions received by Gastroenterology in 1995 and 1996. Reviewers ranked manuscripts in 4 decision categories: accept, provisionally accept, reject with resubmission, or reject.Main Outcome Measure.—Ranking of papers based on nationality of authors and reviewers.Results.—The percentage of non-US manuscripts placed in each decision category by US (n=2355) and non-US reviewers (n=1297) was nearly identical (P=.31). However, US reviewers recommended acceptance of papers submitted by US authors more often than did non-US reviewers (P=.001). Non-US reviewers ranked US papers slightly more favorably than non-US papers (P=.09), while US reviewers ranked US papers much more favorably (P=.001).Conclusions.—Reviewers from the United States and outside the United States evaluate non-US papers similarly and evaluate papers submitted by US authors more favorably, with US reviewers having a significant preference for US papers.
Sudden death in hypertrophic cardiomyopathy: a profile of 78 patients.
Authors: B J Maron, W C Roberts, S E Epstein
Journal: Circulation (1982)

The clinical profile of 78 patients with hypertrophic cardiomyopathy who died suddenly (or experienced cardiac arrest and survived) was analyzed. At the time of cardiac catastrophe, 71% of the patients were younger than 30 years of age, 54% were without functional limitation and 61% were performing sedentary or minimal physical activity. Nineteen of the 78 patients (24%) were taking propranolol in apparently adequate dosages, indicating that this drug does not provide absolute protection against sudden death. No clinical or morphologic variable was particularly reliable in identifying patients at risk for sudden death. Forty-eight of 62 patients (77%) who died suddenly had a markedly increased ventricular septal thickness of 20 mm or more; however, mean septal thickness was similar in patients who died suddenly (25.2 +/- 0.9 mm) and in age- and sex-matched control patients with hypertrophic cardiomyopathy who have survived (23.6 +/- 0.8 mm). An abnormal ECG was present as often in patients who died suddenly as in control patients who have survived, (51 or 53, 96%). In addition, no particular cardiac symptom or hemodynamic variable (such as the magnitude of left ventricular outflow tract obstruction under basal conditions or left ventricular end-diastolic pressure) was characteristic of the patients with hypertrophic cardiomyopathy who died suddenly.
GW25-e4122 The coronary angiographic characteristics of Diabetic patients with high TG/ and low HDL-C
Authors: Yang Zhiming, Hui-Yu Yang, Shu-Wen Gong, Guo-Bin Zhu, Yun-Fei Bian, Fen Gao, Zhi-Ming Yang
Journal: Journal of the American College of Cardiology (2014)
1022-83 The impact of insulin-requiring diabetes mellitus on effectiveness of reperfusion and outcome of patients undergoing primary percutaneous coronary intervention for acute myocardial infarction
Authors: David Antoniucci, Renato Valenti, Angela Migliorini, Guido Parodi, Guia Moschi, Gentian Memisha, Giovanni M Santoro, Giampaolo Cerisano
Journal: Journal of the American College of Cardiology (2004)
Zambia leads the way over international aid
Authors: D. Carlisle
Journal: BMJ (1997)

Developing countries should use Zambia's experience in encouraging international donors to sign up to a national health strategy as an example and put their money into a central “basket” rather than fund their own projects, says a high level international report.

A comprehensive review of Zambia's six year programme of health reform by an international team lead by Halfdan Mahler, the former director general of the World Health Organisation, found that putting money into a central fund or basket administered by the Zambian ministry of health allowed …
Insulin Secretion in Heart Failure
Authors: B. Sharma, P. A. Majid, B. C. Pakrashi, J. R. W. Dykes, S. H. Taylor
Journal: BMJ (1970)

Insulin secretion tests were carried out before and after treatment in patients with severe congestive heart failure. Before treatment the plasma insulin level and the insulin secretion response to intravenous tolbutamide were significantly reduced in all patients. In patients who made a good clinical recovery the plasma insulin level and the insulin secretion response were significantly improved. Patients who had a poor response to medical treatment showed little improvement in their insulin secretion test. This suppression of insulin secretion is probably due to the reduced blood flow to the pancreas together with a high level of circulating catecholamines.
Desmoplastic Small Round Cell Tumor of Meckels Diverticulum
Authors: Sajid S. Qureshi, Mukta R. Ramadwar, Seethalakshmi Viswanathan, Ashish V. Bakshi, Brijesh Arora, Tejpal Gupta, Siddharth Laskar, Seema S. Medhi, Mary A. Muckaden, Shripad D. Banavali, Suresh K. Pai, Sangeeta B. Desai, Purna A. Kurkure
Journal: Journal of Clinical Oncology (2007)
Vertical Transmission of HIV-1. Correlation with maternal viral load and plasma levels of CD4 binding site anti-gp120 antibodies.
Authors: Y F Khouri, K McIntosh, L Cavacini, M Posner, M Pagano, R Tuomala, W A Marasco
Journal: Journal of Clinical Investigation (1995)

Almost all childhood HIV-1 is now acquired through vertical transmission. Identifying factors that affect the rate of transmission may lead to the initiation of specific preventive strategies. In this study, antibody levels against different neutralizing epitopes on the envelope glycoprotein of HIV-1 (gp120) were measured in HIV-1-infected pregnant women that either transmitted HIV-1 to their infants (18 women) or did not (29 women). Differences in levels of antibodies directed against the monomeric gp120 molecule and against the V3 loop region of gp120 were not significantly different between the two groups studied. However, significant differences were observed in the levels of CD4 binding site antibodies, as determined by the ability of diluted maternal plasma to inhibit binding of the CD4 binding site monoclonal antibody F105 (mAb F105) to monomeric gp120. In addition, more nontransmitting mothers had low viral load as defined by having two or more negative HIV-1 viral cultures during pregnancy compared with transmitters. This pilot study suggests that in addition to higher viral load, low levels of CD4 binding site antibodies correlate with increased risk of HIV-1 vertical transmission. Passive immunotherapy with broadly neutralizing CD4 binding site antibodies should be considered as a strategy to reduce this risk.
Feeling of knowing and phenomenal consciousness
Authors: Tiziana Zalla, Adriano P. Palma
Journal: Behavioral and Brain Sciences (1995)

Abstract In Feeling of Knowing cases, subjects have a form of consciousness about the presence of a content (such as an item of information) without having access to it. If this phenomenon can be correctly interpreted as having to do with consciousness, then there would be a P-conscious mental experience which is dissociated from access.
Central sensitisation in visceral pain disorders
Authors: B Moshiree
Journal: Gut (2006)

The concepts of visceral hyperalgesia and visceral hypersensitivity have been examined in a variety of functional gastrointestinal disorders (FGIDs). Although the pathophysiological mechanisms of pain and hypersensitivity in these disorders are still not well understood, exciting new developments in research have been made in the study of the brain-gut interactions involved in the FGIDs
An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E–mediated immediate hypersensitivity reactions
Authors: Kaori Hitomi, Satoko Tahara-Hanaoka, Satoru Someya, Akira Fujiki, Hideaki Tada, Tetsuya Sugiyama, Shiro Shibayama, Kazuko Shibuya, Akira Shibuya
Journal: Nature Immunology (2010)
Domiciliary nebulisers in asthma
Authors: A G Arnold
Journal: BMJ (1985)

others it was the exception rather than the rule for the general practitioner to be present.In order for the general practitioner to be present there must be cooperation between both doctors, who will both have busy schedules.As stated in the original article, the purpose of the service is not only to provide treatment or advice but also to aid the joint consultation between the consultant and the general practitioner.It would seem that this is not occurring in most consultations in the Trent region.
Distributed cell assemblies and detailed cell models
Authors: Anders Lansner, Erik Fransén
Journal: Behavioral and Brain Sciences (1995)

Abstract Hebbian cell-assembly theory and attractor networks are good starting points for modeling cortical processing. Detailed cell models can be useful in understanding the dynamics of attractor networks. Cell assemblies are likely to be distributed, with the cortical column as the local processing unit. Synaptic memory may be dominant in all but the first couple of seconds.
Beneficial Effects Of Polyethylene
Authors: Carl J. De Prizio
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Heat producing modalities in the treatment of muscular and joint complaints are often accompanied by complications. Skin burns of all degrees have occurred in patients upon using hot compresses, electric heating pads, heating lamps, and others. Most doctors prefer to employ types of treatments which are effective and yet be devoid of the danger of injury to the patient. Consequently, the use of polyethylene fabric as a form of wrapping should be given first choice. "In the good old days," flaxseed meal poultices, special broad leaf mattings, and furs and pelts of animals produced added heat for comfort and alleviation of symptoms. Then came the moist compresses, with or without saline or magnesium sulfate ingredients. These were followed by hot water bottles, electric pads, heating lamps, and ultraviolet radiation. More recently, patients have been impressed with other devices such as ultrasonics, diathermy, and spontaneous heat producing water
Glomerular filtration rate, urinary albumin excretion rate, and blood pressure changes in normoalbuminuric normotensive type 1 diabetic patients: an 8-year follow-up study.
Authors: M L Caramori, J L Gross, M Pecis, M J de Azevedo
Journal: Diabetes Care (1999)

To analyze the changes in glomerular filtration rate (GFR), urinary albumin excretion rate (UAER), and blood pressure (BP) levels in a cohort of normoalbuminuric and normotensive type 1 diabetic patients.This is an 8.4+/-2.1-year prospective study of 33 normotensive normoalbuminuric (24-h UAER <20 microg/min) type 1 diabetic patients. UAER (radioimmunoassay), GFR (51Cr-EDTA single-injection technique), and GHb (ion-exchange chromatography) were measured at baseline and at 1- to 2-year intervals.The GFR decreased (137.6+/-16.5 to 116.4+/-21.3 ml x min(-1) x 1.73 m(-2) P < 0.05) during the follow-up period. GFR reduction (-0.20+/-0.29 ml x min(-1) x month(-1); P < 0.05) was associated with baseline GFR and mean GHb (R2 = 0.30; beta = 0.072; F = 6.54; P = 0.004). UAER was higher at the end of the study (3.7-7.1 microg/min; P = 0.017). Microalbuminuria was observed in two patients, while macroalbuminuria was observed in one. No changes in UAER were observed when these three patients were excluded from the analysis. Mean blood pressure (MBP) increased during the study (85.8+/-9.7 to 99.6+/-11.6 mmHg; P < 0.001). MBP at the end of the study was associated with age and GFR at baseline (R2 = 0.39; beta = 0.074; F = 9.64; P = 0.001).In this cohort of normoalbuminuric normotensive type 1 diabetic patients, GFR decreased and BP levels increased during the follow-up period. The predictors for the GFR change were baseline GFR level and metabolic control. For end-of-study MBP, the predictor was baseline GFR level.
What Influences the Frequency of Angiography … Cardiologists?
Authors: John Page
Journal: Annals of Internal Medicine (1997)

Letters1 August 1997What Influences the Frequency of Angiography … Cardiologists?John Page, MD and Bertrand M. Bell, MDJohn Page, MDAlbert Einstein College of Medicine; Bronx, NY 10461Search for more papers by this author and Bertrand M. Bell, MDAlbert Einstein College of Medicine; Bronx, NY 10461Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-3-199708010-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Tu and colleagues are to be commended for their thought-provoking article [1]. However, two important points of difference were omitted from analysis and from discussion in the paper.Tu and colleagues do mention, in one sentence, that 90% of the patients in New York State had Canadian Cardiovascular Society class 3 or 4 angina. However, they have based their paper on the objective finding that the severity of coronary artery disease can be defined on the basis of angiographic abnormality. Although anatomic categorization is important, it can be only an intermediate step in the management of ischemic ...References1. Tu JV, Naylor CD, Kumar D, DeBuono BA, McNiel BJ, Hannan EL, et al. Coronary artery bypass graft surgery in Ontario and New York State: which rate is right? Ann Intern Med. 1997; 126:13-9. Google Scholar2. Bittl JA. Advances in coronary angioplasty. N Engl J Med. 1996; 335:1290-1302. Google Scholar Author, Article, and Disclosure InformationAffiliations: Albert Einstein College of Medicine; Bronx, NY 10461 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPropensity score-integrated power prior approach for incorporating real-world evidence in single-arm clinical studies 1 August 1997Volume 127, Issue 3Page: 244-245KeywordsAnginaAngiographyCoronary angioplastyCoronary arteriesLesionsMyocardial infarctionPercutaneous transluminal coronary angioplastyStable coronary artery diseaseStenosisSurgery Issue Published: 1 August 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Mixed matrix hollow fiber membranes for removal of protein-bound toxins from human plasma
Authors: Marlon S.L. Tijink, Maarten Wester, Griet Glorieux, Karin G.F. Gerritsen, Junfen Sun, Pieter C. Swart, Zandrie Borneman, Matthias Wessling, Raymond Vanholder, Jaap A. Joles, Dimitrios Stamatialis
Journal: Biomaterials (2013)
A theoretical basis for investigating ambient air pollution and children's respiratory health.
Authors: F D Gilliland, R McConnell, J Peters, H Gong
Journal: Environmental Health Perspectives (1999)

Acute respiratory health effects in children from exposure at current ambient levels of ozone are well documented; however, evidence for acute effects from other criteria pollutants such as nitrogen dioxide and respirable particles is inconsistent. Whether chronic effects result from long-term exposure to any of these pollutants during childhood is an important unresolved question. Establishing whether acute or chronic effects result from childhood exposure and identifying sensitive subgroups may require integration of biologic mechanisms of lung defenses, injury, and response into the study design and statistical models used in analyses. This review explores the theoretical basis for explaining such adverse effects in light of our contemporary understanding of mechanisms of lung injury and response at the cellular and molecular levels. The rapidly evolving understanding of the effects of air pollution on cellular and molecular levels presents an opportunity to develop and refine innovative biologically based hypotheses about the effects of childhood exposure. We hypothesize that children with low fruit and vegetable intake, low antioxidant levels, high polyunsaturated fat intake, or who have inherited certain alleles for genes involved in lung defenses and immune response regulation may be at increased risk for adverse effects. Because responses to air pollutants of interest are complex and involve a number of pathophysiologic processes, the magnitude of main effects of dietary factors, genes, and gene-environment interactions may be modest for individuals; however, each may make an important contribution to the population burden of preventable respiratory diseases.