tbuckley/cabot-search huggingface dataset:
CARRIER FREE RADIOIODINATED COCAINE
Authors: G. P. Basmadjian, S. Jain, M. H. Kanvinde, S. Lmills, J. C. Leonard'
Journal: Clinical Nuclear Medicine (1991)

Basmadjian, G. P.; Jain, S.; Kanvinde, M. H.; Lmills, S.; Leonard', J. C. Author Information
Prolonged Survival in Lymphangitic Carcinomatosis
Authors: MARVIN I. SCHWARZ
Journal: Annals of Internal Medicine (1969)

A 60-year-old man had documented adenocarcinoma of the prostate and lymphangitic metastases to the lung. After orchiectomy there was marked improvement documented by serial pulmonary function studies and chest X rays. The patient's relatively asymptomatic state and prolonged survival differ markedly from the clinical course previously described in this disease.
Poorer health among disabled people to be investigated
Authors: Zosia Kmietowicz
Journal: BMJ (2004)

The reasons why people with learning disabilities and mental health problems die younger than the general population and what can be to close this health gap are to be scrutinised over the next 18 months in a formal investigation by the Disability Rights Commission.

According to the commission, people with learning disabilities and mental health problems are among the poorest and most disadvantaged in society. They die younger of preventable diseases than the rest of the population and miss out on life saving screening programmes.

Evidence gathered by the commission shows that the number of preventable deaths among people with …
Social inequalities in self reported health in early old age: follow-up of prospective cohort study
Authors: Tarani Chandola, Jane Ferrie, Amanda Sacker, Michael Marmot
Journal: BMJ (2007)

<b>Objective</b> To describe differences in trajectories of self reported health in an ageing cohort according to occupational grade. <b>Design</b> Prospective cohort study of office based British civil servants (1985-2004). <b>Participants</b> 10 308 men and women aged 35-55 at baseline, employed in 20 London civil service departments (the Whitehall II study); follow-up was an average of 18 years. <b>Main outcome measures</b> Physical component and mental component scores on SR-36 measured on five occasions. <b>Results</b> Physical health deteriorated more rapidly with age among men and women from the lower occupational grades. The average gap in physical component scores between a high and low grade civil servant at age 56 was 1.60 and this gap increased by 1 over 20 years. The average physical health of a 70 year old man or woman who was in a high grade position was similar to the physical health of a person from a low grade around eight years younger. In mid-life, this gap was only 4.5 years. Although mental health improved with age, the rate of improvement is slower for men and women in the lower grades. <b>Conclusions</b> Social inequalities in self reported health increase in early old age. People from lower occupational grades age faster in terms of a quicker deterioration in physical health compared with people from higher grades. This widening gap suggests that health inequalities will become an increasingly important public health issue, especially as the population ages.
Prognosis of patients with left ventricular dysfunction, with and without viable myocardium after myocardial infarction. Relative efficacy of medical therapy and revascularization.
Authors: K S Lee, T H Marwick, S A Cook, R T Go, J S Fix, K B James, S K Sapp, W J MacIntyre, J D Thomas
Journal: Circulation (1994)

BACKGROUND The uptake of F-18 deoxyglucose into dysfunction segments after myocardial infarction identifies metabolically active (FDG+) or inactive (FDG-) myocardium. Although patients with FDG+ segments have been found to be at risk for adverse events, the prognostic significance of viable myocardium in relation to other influences on postinfarction prognosis, including revascularization, remain ill defined. The purpose of this study was to investigate the relative prognostic significance of FDG+ tissue and to establish whether myocardial revascularization in patients with viable tissue attenuates the risk of adverse outcome. METHODS AND RESULTS One hundred thirty-seven patients with left ventricular dysfunction and resting perfusion defects after myocardial infarction underwent positron emission tomography with both dipyridamole stress Rb-82 perfusion imaging and FDG imaging. After the exclusion of 4 patients proceeding to transplantation, 2 with uninterpretable scans and 2 lost to follow-up, 129 patients were followed clinically for 17 +/- 9 months. Four groups were defined: patients with FDG+ dysfunctional myocardium who were revascularized (n = 49) or treated medically (n = 21) and those with FDG- segments who were revascularized (n = 19) or treated medically (n = 40). The groups of patients with FDG+ or FDG- findings, with and without revascularization, did not differ with respect to known determinants of postinfarction prognosis: age, left ventricular ejection fraction, or the prevalence of multivessel disease. Nonfatal ischemic events occurred in 48% of medically treated FDG+ patients compared with 8% of revascularized patients with FDG+ tissue (P &lt; .001) and 5% of patients with FDG- myocardium (P &lt; .001). Thirteen patients died from cardiac causes; 11 (85%) had a left ventricular ejection fraction of &lt; 30%, and these patients were evenly distributed between FDG+ and FDG- groups. Using Cox's proportional hazards model, only the presence of FDG+ myocardium (odds ratio, 12.9; P &lt; .001) and the absence of revascularization (odds ratio, 5.8; P = .002) independently predicted ischemic events, while only age (P = .02) and ejection fraction (P &lt; .001) but not the presence of viable myocardium were predictive of death. CONCLUSIONS Residual viable myocardium after myocardial infarction may act as an unstable substrate for further events unless it is revascularized. Despite this association, age and left ventricular dysfunction remained the strongest predictors of cardiac death after myocardial infarction in these patients with a spectrum of left ventricular dysfunction.
Diagnosis and Management of Female Infertility
Authors: Samuel Smith, Samantha M. Pfeifer, John A. Collins
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Electrocardiographic ST-Segment Depression and Exposure to Traffic‐Related Aerosols in Elderly Subjects with Coronary Artery Disease
Authors: Ralph J. Delfino, Daniel L. Gillen, Thomas Tjoa, Norbert Staimer, Andrea Polidori, Mohammad Arhami, Constantinos Sioutas, John Longhurst
Journal: Environmental Health Perspectives (2010)

Air pollutants have not been associated with ambulatory electrocardiographic evidence of ST-segment depression ≥ 1 mm (probable cardiac ischemia). We previously found that markers of primary (combustion-related) organic aerosols and gases were positively associated with circulating biomarkers of inflammation and ambulatory blood pressure in the present cohort panel study of elderly subjects with coronary artery disease.We specifically aimed to evaluate whether exposure markers of primary organic aerosols and ultrafine particles were more strongly associated with ST-segment depression of ≥ 1 mm than were secondary organic aerosols or PM2.5 (particulate matter with aerodynamic diameter ≤ 2.5 µm) mass.We evaluated relations of air pollutants to ambulatory electrocardiographic evidence of cardiac ischemia over 10 days in 38 subjects without ST depression on baseline electrocardiographs. Exposures were measured outdoors in retirement communities in the Los Angeles basin, including daily size-fractionated particle mass and hourly markers of primary and secondary organic aerosols and gases. Generalized estimating equations were used to estimate odds of hourly ST-segment depression (≥ 1 mm) from hourly air pollution exposures and to estimate relative rates of daily counts of ST-segment depression from daily average exposures, controlling for potential confounders.We found significant positive associations of hourly ST-segment depression with markers of combustion-related aerosols and gases averaged 1-hr through 3-4 days, but not secondary (photochemically aged) organic aerosols or ozone. The odds ratio per interquartile increase in 2-day average primary organic carbon (5.2 µg/m3) was 15.4 (95% confidence interval, 3.5-68.2). Daily counts of ST-segment depression were consistently associated with primary combustion markers and 2-day average quasi-ultrafine particles < 0.25 µm.Results suggest that exposure to quasi-ultrafine particles and combustion-related pollutants (predominantly from traffic) increase the risk of myocardial ischemia, coherent with our previous findings for systemic inflammation and blood pressure.
Microbiome Project Seeks to Understand Human Body’s Microscopic Residents
Authors: M. J. Friedrich
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
967-18 Clinical Experience with Medtronic Wiktor Stent Implantation: A Report from the French Multicentric Registry
Authors: Elie K. Karouny, Khalife Khalife, Jean-Pierre Monassier, Bernard Lancelin, Gilles Grollier, Didier Carrié, Bernard Assoun, Michel Jean, Jacques Puel
Journal: Journal of the American College of Cardiology (1995)
<i>ACTN</i>3 genotype in professional soccer players
Authors: C Santiago, M González-Freire, L Serratosa, F J Morate, T Meyer, F Gómez-Gallego, A Lucia
Journal: British Journal of Sports Medicine (2007)

The authors studied the frequency distribution of α-actinin-3 ( ACTN 3) R577X genotypes in 60 top-level professional soccer players. The results were compared with those of 52 elite endurance athletes and 123 sedentary controls. The per cent distribution of RR and RX genotypes in soccer players (48.3% and 36.7%) was significantly higher and lower, respectively, than controls (28.5% and 53.7%) and endurance athletes (26.5% and 52%) (p = 0.041). Although there are notable exceptions, elite soccer players tend to have the sprint/power ACTN3 genotype.
Microbial inciters of acute asthma in urban Nigerian children.
Authors: D A Gbadero, A W Johnson, W I Aderele, O D Olaleye
Journal: Thorax (1995)

BACKGROUND--In tropical Africa the role of microbial agents of acute respiratory infections in acute exacerbations of bronchial asthma remains largely unexplored. However, empirical antibacterial therapy is frequently initiated in moderate to severe cases of acute asthma with symptoms of acute respiratory infection. A study was set up to determine how often acute respiratory infection is associated with acute asthma, to identify the associated pathogens, and to proffer appropriate therapeutic suggestions. METHODS--Over a 16 month period, 86 episodes of acute asthma were studied for clinical and laboratory features of acute respiratory infection at the University College Hospital (UCH), Ibadan. Virological diagnosis was based on immunofluorescence studies of nasopharyngeal aspirates and/or serological tests using the microtitre complement fixation technique. Throat swabs and blood were cultured for bacterial agents. RESULTS--Of the 64 cases who presented with rhinorrhoea, 51 (79.7%) were pyrexial (T &gt; or = 37.6 degrees C). Inflammatory changes (frequently interstitial streakiness) were identified in 10 (19.6%) of the 51 chest radiographs; only two of these had lobar shadowing. Significant bacterial isolates were made in only three (3.5%) of the throat swabs and two (2.4%) of the blood cultures from the 86 cases; none had clinical septicaemia. On the other hand, 55 viral agents were identified from 39 (53%) of the 74 subjects studied; 16 (41.0%) had dual viral identifications. Respiratory syncytial virus (RSV) accounted for 20 (36.4%) identifications, parainfluenza virus (PIV) type 3 for 15 (27.3%), and influenza type A (Flu A) for 12 (21.8%). Viral identifications were significantly higher in infants and preschool subjects (&lt; 5 years) and in those presenting with either rhinorrhoea or pyrexia. CONCLUSIONS--The results of this study underscore the importance of viral upper respiratory infections in asthma exacerbations in a tropical setting. The paucity of clinical and investigative features of bacterial acute respiratory infection suggests that there is little rationale for routine antibiotic cover in children with acute exacerbations of asthma in the tropics.
Importance of the dynamics between patients with personality disorder and the doctors treating them
Authors: T. R. Gedeon
Journal: BMJ (2013)

Gask and colleagues’ article highlights the prevalence of personality disorders and the challenges these patients present.1

When managing such patients (particularly those with emotionally unstable personality disorder) we must be mindful of transference and countertransference, which can be much more prominent than with other patient encounters. Transference is the unconscious transfer of feelings and attitudes from a person or situation in the …
Renal artery repair. Normal blood pressure and renal function 20 years later
Authors: L. S. Marks
Journal: JAMA (1976)

THE FIRST successful arterial repair for renovascular hypertension in man was reported inThe Journalby Freeman and associates in 1954.<sup>1</sup>Subsequently, arterial repair (or replacement) has become a widely accepted therapy for this condition. Since many candidates for such an operation are young, it is desirable to know how long the repaired or reconstructed renal artery can provide for adequate blood flow to the kidney. Unfortunately, this kind of information is scarce. The following report demonstrates that a repaired artery can provide adequate flow of blood to the kidney for as long as 20 years. <h3>Report of a Case</h3> A 23-year-old woman came to the emergency room of UCLA Hospital on Oct 4, 1955, for treatment of a bee sting. Her blood pressure was 200/130 mm Hg. A subsequent examination showed stenosis of the right renal artery. Ureteric catheterization studies showed diminished urine flow and decreased phenolsulfonphthalein (PSP)
FDA Promotes Safer Use of Analgesics in Older Adults With Chronic Pain
Authors: Bridget M. Kuehn
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevention and Reversal of Atrial Fibrillation Inducibility and Autonomic Remodeling by Low-Level Vagosympathetic Nerve Stimulation
Authors: Xia Sheng, Benjamin J. Scherlag, Lilei Yu, Shuyan Li, Reza Ali, Ying Zhang, Guosheng Fu, Hiroshi Nakagawa, Warren M. Jackman, Ralph Lazzara, Sunny S. Po
Journal: Journal of the American College of Cardiology (2011)
Drugs and the fetus
Authors: P. Vallance
Journal: BMJ (1996)

Doctors, patients, and the pharmaceutical industry are all cautious about the use of drugs during pregnancy.1 Few applications for product licences for new drugs include use in pregnancy, and the British National Formulary warns that all drugs should be avoided if possible during the first trimester. Inflexible application of this guideline may lead to pregnant women being denied effective drug treatments. By contrast, lack of awareness of the risks may allow potentially teratogenic drugs to be prescribed to pregnant women and, much more commonly, to women of childbearing age who may become pregnant.

Drugs can cause fetal death or damage at any stage of pregnancy. Anticancer drugs, for example, inhibit cell replication and so may cause the death of the embryo during blastocyst formation (0-16 days). Later in pregnancy (second and third trimester), drugs such as β blockers may cause general retardation of growth, while others may affect maturation of specific organ systems—for example, angiotensin converting enzyme inhibitors cause abnormalities of renal function and skull development.2 …
Doctors should listen to the whole patient: don't forget the stethoscope in neurological examination
Authors: C. M. Burd
Journal: BMJ (2013)

John Forbes, physician to Queen Victoria, said of the newly invented stethoscope, “I have no doubt whatever . . . that it will be acknowledged to be one of the greatest discoveries in medicine by all those . . . to give it a fair trial.” The humble stethoscope is already a key part of cardiovascular, respiratory, and abdominal examinations. It can also be of great value in diagnosing a multitude of neurological disorders, from stroke to tremor.

Hearing a carotid bruit has a sensitivity of 56% and specificity of 98% in detecting carotid stenosis at at least 60% occlusion,1 and it may help identify patients with worse prognoses. …
Ultrastructure of pityriasis rubra pilaris with observations during retinoid (etretinate) treatment
Authors: L. KANERVA, J. LAUHARANTA, K.-M. NIEMI, A. LASSUS
Journal: British Journal of Dermatology (1983)

Journal Article Ultrastructure of pityriasis rubra pilaris with observations during retinoid (etretinate) treatment Get access L. KANERVA, L. KANERVA Departments of Dermatology, Anatomy and Electron Microscopy, University of Helsinki, and Institute of Occupational Health, Helsinki, Finland Lasse Kanerva, M.D., Ph.D., Department of Dermatology, University Central Hospital, Snellmaninkatu 14, 00170 Helsinki 17, Finland. Search for other works by this author on: Oxford Academic Google Scholar J. LAUHARANTA, J. LAUHARANTA Departments of Dermatology, Anatomy and Electron Microscopy, University of Helsinki, and Institute of Occupational Health, Helsinki, Finland Search for other works by this author on: Oxford Academic Google Scholar K.‐M. NIEMI, K.‐M. NIEMI Departments of Dermatology, Anatomy and Electron Microscopy, University of Helsinki, and Institute of Occupational Health, Helsinki, Finland Search for other works by this author on: Oxford Academic Google Scholar A. LASSUS A. LASSUS Departments of Dermatology, Anatomy and Electron Microscopy, University of Helsinki, and Institute of Occupational Health, Helsinki, Finland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 108, Issue 6, 1 June 1983, Pages 653–663, https://doi.org/10.1111/j.1365-2133.1983.tb01077.x Published: 01 June 1983 Article history Accepted: 04 October 1982 Published: 01 June 1983
Adding heat to the live-high train-low altitude model: a practical insight from professional football
Authors: M Buchheit, S Racinais, J Bilsborough, J Hocking, A Mendez-Villanueva, P C Bourdon, S Voss, S Livingston, R Christian, J Périard, J Cordy, A J Coutts
Journal: British Journal of Sports Medicine (2013)

Objectives To examine with a parallel group study design the performance and physiological responses to a 14-day off-season ‘live high-train low in the heat’ training camp in elite football players. Methods Seventeen professional Australian Rules Football players participated in outdoor football-specific skills (32±1°C, 11.5 h) and indoor strength (23±1°C, 9.3 h) sessions and slept (12 nights) and cycled indoors (4.3 h) in either normal air (NORM, n=8) or normobaric hypoxia (14±1 h/day, FiO 2 15.2–14.3%, corresponding to a simulated altitude of 2500–3000 m, hypoxic (HYP), n=9). They completed the Yo-Yo Intermittent Recovery level 2 (Yo-YoIR2) in temperate conditions (23±1°C, normal air) precamp (Pre) and postcamp (Post). Plasma volume (PV) and haemoglobin mass (Hb mass ) were measured at similar times and 4 weeks postcamp (4WPost). Sweat sodium concentration ((Na + ) sweat ) was measured Pre and Post during a heat-response test (44°C). Results Both groups showed very large improvements in Yo-YoIR2 at Post (+44%; 90% CL 38, 50), with no between-group differences in the changes (−1%; −9, 9). Postcamp, large changes in PV (+5.6%; −1.8, 5.6) and (Na + ) sweat (−29%; −37, −19) were observed in both groups, while Hb mass only moderately increased in HYP (+2.6%; 0.5, 4.5). At 4WPost, there was a likely slightly greater increase in Hb mass (+4.6%; 0.0, 9.3) and PV (+6%; −5, 18, unclear) in HYP than in NORM. Conclusions The combination of heat and hypoxic exposure during sleep/training might offer a promising ‘conditioning cocktail’ in team sports.
Autonomy Support to Foster Individuals’ Flourishing
Authors: Saskia K. Nagel, Peter B. Reiner
Journal: The American Journal of Bioethics (2013)

Click to increase image sizeClick to decrease image size Acknowledgments Saskia K. Nagel acknowledges the German Ministry of Research and Education for its financial support (01GP1010), and Peter B. Reiner is supported by a grant from the Canadian Institutes of Health Research.