Aspirin in the Management of Recurrent Herpes Simplex Virus Infection
Authors: Istvan Karadi
Journal: Annals of Internal Medicine (1998)

Letters15 April 1998Aspirin in the Management of Recurrent Herpes Simplex Virus InfectionIstvan Karadi, MD, PhD, Sarolta Karpati, DSc, and Laszlo Romics, DScIstvan Karadi, MD, PhDSemmelweis Medical University; Budapest, Hungary, Sarolta Karpati, DScSemmelweis Medical University; Budapest, Hungary, and Laszlo Romics, DScSemmelweis Medical University; Budapest, HungaryAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-8-199804150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Recurrent facial-oral or genital herpes simplex virus (HSV-1 and HSV-2) infections affect 28% and 1.1% of the population of college students in the United States, respectively [1]. The painful symptoms can disturb usual activities, and complete recovery often takes 8 to 9 days.A 45-year-old man with severe recurrent herpes labialis had a myocardial infarction and began receiving aspirin, 125 mg/d. After 3 months, the patient reported complete disappearance of the herpetic episodes. Aspirin was his only new medication.To explore the effect of aspirin, we recruited 21 volunteers with recurrent HSV infection (mean age ±SD, 29 ...References1. Gibson JJ, Hornug CA, Alexander GR, Lee FK, Potts WA, Nahmias AJ. A cross-sectional study of herpes virus types 1 and 2 in college students: occurrence and determination of infection. J Infect Dis. 1990; 162:306-12. Google Scholar2. Huang RT, Dietsch E. Anti-influenza viral activity of aspirin in cell culture [Letter]. N Engl J Med. 1988; 319:797. Google Scholar3. Bitko V, Velasquez A, Yang L, Yang YC, Barik S. Transcriptional induction of multiple cytokines by human respiratory syncytial virus requires activation of NF-κ B and is inhibited by sodium salicylate and aspirin. Virology. 1997; 232:369-78. Google Scholar4. Osnes LT, Foss KB, Joo GB, Okkenhaug C, Westvik AB, Ovstebo R, et al. Acetylsalicylic acid and sodium salicylate inhibit LPS-induced NF-κ B/c-Rel nuclear translocation, and synthesis of tissue factor (TF) and tumor necrosis factor alfa (TNF-α) in human monocytes. Thromb Haemost. 1996; 76:970-6. Google Scholar5. Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR. Selectivity of nonsteroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993; 90:11693-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: Semmelweis Medical University; Budapest, Hungary PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHerpes Simplex VirusInhibition of Cyclooxygenase 2 Synthesis Suppresses Herpes simplex Virus Type 1 ReactivationDental health for the pediatrician 15 April 1998Volume 128, Issue 8Page: 696-697KeywordsAntiviralsAspirinCell culturesCytokinesGenital anatomyHerpes simplexMyocardial infarctionProstaglandinsProtein synthesis Issue Published: 15 April 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...