tbuckley/cabot-search huggingface dataset:
Peripheral T cell lymphoma not otherwise specified with Reed‐Sternberg like cells
Authors: Prabhjot Kaur, Norman B. Levy
Journal: American Journal of Hematology (2011)

This is an uncommon case of a peripheral T cell lymphoma, not otherwise specified (PTCL-NOS) containing Reed–Sternberg (R–S) like cells expressing CD15 and CD30. The lymph node is effaced by a polymorphous population of small, intermediate, and large lymphocytes amidst a background of histiocytes, plasma cells, and abundant eosinophils (Image 1). Sclerosis is also present, producing a nodular pattern (Image 1B). Among the large cells are multi-nucleate cells with Reed–Sternberg like cytology (Image 1A inset). The panel of immunostains performed included CD3, CD4, CD5, CD8, CD15, CD20, CD30, CD43, CD45, ALK1, and PAX5. The intermediate and large lymphocytes are positive for CD30 (Image 1C) and CD43 (Image 1E). Rare large R–S like cells also coexpress CD15 (Image 1D). PCR analysis detected a clonal gamma T cell receptor gene rearrangement. A: Polymorphous distribution of cells (hematoxylin-eosin, original magnification ×400) including Reed–Sternberg like cells (inset). B: Sclerosis is present, producing a nodular pattern. C: CD30 (original magnification ×400). D:CD15 (original magnification ×400). E: CD43 (original magnification ×400). Cases of PTCL-NOS containing R–S like cells expressing CD15 and CD30 have been reported [1-3]. Distinction from Hodgkin lymphoma requires careful assessment of morphology and immunophenotype, and is assisted by gene rearrangement analysis. Classical Hodgkin lymphoma is characterized by classic R–S cells and variants in a background of reactive eosinophils, plasma cells, macrophages, and cytologically benign small lymphocytes. Intermediate and large sized transformed lymphocytes are not seen. PTCLs, in contrast, contain cytologically atypical small and intermediate sized lymphocytes in addition to the atypical large forms. Reed Sternberg cells typically express CD15, CD30, and nuclear Pax 5, and are CD45 negative. The neoplastic T cells of PTCL typically express CD45 and pan T cell antigens, often with aberrant loss of one of more. They are Pax5 negative. However, Reed–Sternberg cells may not express CD15 or nuclear Pax5 [4], and assessment of CD45 expression is often difficult because of its encirclement of R–S cells by CD45 positive T cells. Similarly, the loss of T cell antigens by PTCL cells can be extensive, obscuring lineage. Underappreciated in this setting is the value of CD43. Although CD43 is expressed by a wide range of hematopoietic cells in addition to T cells, it is not expressed on the membrane of R–S cells [5], but is expressed by the great majority of PTCLs.
Reuse of a Transplanted Heart
Authors: Miralem Pasic, Augusto Gallino, Thierry Carrel, Marco Maggiorini, Andreas Laske, Ludwig von Segesser, Marko Turina
Journal: New England Journal of Medicine (1993)

Many patients are waiting for heart transplantation, and some of them will die before surgery because of the lack of donor organs1. The increased demand for cardiac transplantation in the face of a relatively fixed supply of donor hearts has meant that the average waiting time has lengthened. It is estimated that in the United States alone, 2000 patients per month need cardiac transplants, whereas the number of transplantation procedures has remained steady at approximately 100 per month2. Recently we were faced with an unusual clinical situation when one of our heart-transplant recipients suffered brain death after an . . .
Ultrasonic Diagnosis of Cruveilhier-Baumgarten Syndrome
Authors: Jean-Pierre Capron
Journal: JAMA (1982)

<h3>History</h3> A 46-year-old alcoholic man was hospitalized because of mild hematemesis. Clinical examination revealed the presence of hepatomegaly and evidence of a moderately extensive abdominal collateral circulation. Findings from abdominal auscultation were normal. Endoscopy of the upper gastrointestinal tract demonstrated small, nonbleeding esophageal varices and hemorrhagic gastritis. Serum bilirubin level was 1.3 mg/dL. The SGPT value was 47 IU. The alkaline phosphatase was 185 IU (normal, less than 170 IU). The albumin level was 3.2 g/dL and the γ-globulin level was 1.8 g/dL. The prothrombin time was 75% of the control. A gray-scale ultrasonogram was obtained. The liver appeared normal, and the portal axis was patent. A tubular channel (Fig 1) (small arrows) was observed transversing the area from the portal vein (large arrow) to the umbilical area (asterisk). <h3>Diagnosis</h3> Cruveilhier-Baumgarten syndrome. <h3>Comment</h3> The tubular channel noted in the ultrasonogram in Fig 1 was interpreted as a probable umbilical vein.
Clinical Paths: Tools for Outcomes Management
Authors: Prentiss Taylor
Journal: JAMA (1995)

In the past two to five years, many hospitals have begun to address the problem of widespread variation in physician practice styles by local development of "Clinical Paths," also known as "Critical Paths" and other synonyms. The intent of such pathways is generally to produce much greater reliability in favorable patient (and institutional) outcomes in terms of length of stay (LOS). Clearly, the impetus of these efforts is to affect the financial bottom line of hospitals and to guarantee quality in terms of related morbidity and mortality. This book is the product of a diverse group of physician and nurse quality management specialists, clinical nurse specialists, and medical department chairpersons in community hospitals and university medical centers. Its contributors even include a pharmacist and an attorney. Part 1 discusses how paths have evolved and factors that lead to relative success or failure in implementation. An introduction to the evolving fields
1108-127 Determinants of exercise capacity in hypertrophic cardiomyopathy are different in patients with or without heart failure
Authors: Cinzia Cianfrocca, Francesco Pelliccia, Antonio Auriti, Gerardo Ansalone, Vincenzo Guido, Paride Giannantoni, Antonino Granatelli, Giuseppe Richichi, Massimo Santini
Journal: Journal of the American College of Cardiology (2004)
Disseminated Intravascular Coagulation —A Color of Different Horses
Authors: Samuel Vaisrub
Journal: JAMA (1975)

Disease complications generally fall into one of two categories. They may be unrelated diseases caused by organisms invading a host whose resistance had been undermined. Thus, otitis media or pneumonia may complicate measles. Alternatively, they may be unsurprising adverse developments in a severe disease of a specific organ. Such a complication is hepatic coma in hepatic cirrhosis, or uremia in chronic renal disease. A complication that does not quite fit either of the two categories is disseminated intravascular coagulation (DIC). It is neither a secondary infection, nor a predictable outcome of a specific organ disease. More often than not it is an unexpected development in a wide variety of conditions. Its hallmark is the paradoxical coexistence of thrombosis and hemorrhage. The former is initiated by thromboplastic substances, damaged platelets, injured vascular endothelium, and other as yet unidentified mechanisms that activate clotting. As a consequence of the widespread clotting, there is
Think Tank's report shelved, but not ditched
Authors: W. Russell
Journal: BMJ (1982)

The report of the Think Tank on, among other things, the National Health Service that caused such dissension in the Cabinet is a dead duck.We have the word of Mr Cecil Parkin- son, chairman of the Conservative Party, as well as the assurance by Mr Norman Fowler, Social Services Secretary, to last week's Conservative Party conference that taxation will remain the predominant way of financing the National Health Service to back it up.And in her closing speech to the conference the Prime Minister said that she wanted to make it "absolutely clear" that "the NHS is safe with us."So what was all the row about?Ministers were in no doubt-when the report proposing the change to a health service based on insurance funding landed in their red boxes-that whatever the logic of the plan it was politically impossible.They decided, therefore, to take no action and were urged by the Prime Minister to go away and think about the lessons that they might learn for their various depart- ments.Mrs Thatcher then departed for the Far East and the contents of the report were leaked together with accounts of the shock horror it had caused all wet-thinking men in the Cabinet.
The Two Cultures of Biomedicine: Can There Be Consensus?
Authors: Ann Lennarson Greer
Journal: JAMA (1987)

There is a tendency to assume that medical science, medical research, and medical practice are identical, or worse, hierarchically arranged. Medical practice does operate under the umbrella of medical science, but medical practitioners do not take practice directives from medical researchers. In conceptualizing and promoting a notion of medical "consensus" that is different from scientific certainty, the National Institutes of Health has taken a giant step toward bridging the gap between research and practice, but the task is a tough one. My vantage point is from personal interviews with more than 300 mostly nonacademic practicing physicians in three countries who described adoption of new medical technology.<sup>1-3</sup> The first step in conceptualizing the relationship between science and practice should be to reject the idea that practitioners are merely slow scientists. Just as science is not practice, practice is not merely applied science. Different purposes lead to different activities, associations, information,
A Place to Clean the Teeth Needed in Railroad Car.
Authors: Henry D. Fulton
Journal: JAMA (1901)

Pittsburgh, Pa., Oct. 28, 1901. <h3>To the Editor:</h3> —Apropos of the much discussed question of the spitting nuisance, the attention of the managers of the sleeping car companies should be called to the practice of cleaning the teeth and spitting in the bowls of the washroom, in violation of every principle of decency, good taste and sound hygiene. A sign in conspicuous form and in unmistakable terms, should be placed in the lavatories of sleeping cars, positively forbidding spitting, cleaning the teeth or blowing the nose in the washbowls. Nothing more unpleasant can be imagined than to witness the actions of the unclean animal, as he performs his morning ablutions, brushing his teeth and spluttering and snorting over the bowl. One's gorge rises at the sight, when a person reflects that he must wash in the same place or forego the comfort of having the facilities of keeping clean. The
Gallium Uptake in Myositis Ossificans Potential Pitfalls in Diagnosis
Authors: LINDA SALZMAN, VICTOR W. LEE, PHILIP GRANT
Journal: Clinical Nuclear Medicine (1987)

Seven cases of gallium uptake in myositis ossificans are described. Gallium scans are done frequently in paraplegics, quadriplegics, and comatose patients to look for occult infection. It is important to be aware of possible gallium uptake in myositis ossificans, particularly in the extremities, which is frequent in these patients. Gallium uptake may be present prior to any abnormalities seen on plain films or CT scans. It is important to correlate roentgenograms with abnormal gallium scans, particularly in the extremities, to avoid potential pitfalls in diagnosis and prevent unnecessary antibiotic treatment. A bone scan should be obtained whenever possible, particularly when roentgenograms are negative, to confirm the diagnosis.
Prognostic Value of Dipyridamole Stress Cardiovascular Magnetic Resonance Imaging in Patients With Known or Suspected Coronary Artery Disease
Authors: Vicente Bodi, Juan Sanchis, Maria P. Lopez-Lereu, Julio Nunez, Luis Mainar, Jose V. Monmeneu, Oliver Husser, Eloy Dominguez, Francisco J. Chorro, Angel Llacer
Journal: Journal of the American College of Cardiology (2007)
Rush Oral Immunotherapy For Wheat-induced Anaphylaxis In Japan
Authors: T. Utsunomiya, T. Imai, K. Ogura, M. Goto, K. Iikura, Y. Koike, K. Otani, S. Sato, A. Shukuya, M. Ebisawa
Journal: Journal of Allergy and Clinical Immunology (2012)
Racial Differences in Incident Heart Failure among Young Adults
Authors: Kirsten Bibbins-Domingo, Mark J. Pletcher, Feng Lin, Eric Vittinghoff, Julius M. Gardin, Alexander Arynchyn, Cora E. Lewis, O. Dale Williams, Stephen B. Hulley
Journal: New England Journal of Medicine (2009)

We prospectively assessed the incidence of heart failure over a 20-year period among 5115 blacks and whites of both sexes who were 18 to 30 years of age at baseline. Using Cox models, we examined predictors of hospitalization or death from heart failure.
Endoscopic surveillance in Barrett's oesophagus
Authors: J Ryan
Journal: Gut (2003)

I read with interest the debate on endoscopic surveillance in Barrett’s oesophagus ( Gut 2002; 51 :313–14, 314–15). My reading of the literature supports the view of Dr Playford—there is insufficient evidence to justify surveillance endoscopy in this condition.

I am always interested in the uses and misuses of statistical data to support a personal view, and to that end I have some questions that should be honestly answered by those advocating screening: firstly, where is the evidence, prospectively collected, that shows that Barrett’s oesophagus is a consequence of acid reflux disease? The quoted references do not support this allegation. Secondly, I believe that it is deliberately obfuscatory to liken Barrett’s oesophagus to a colonic polyp in terms of malignant potential—abundant evidence supports the role of screening in the latter common condition. Lastly, this issue …
RECIPROCAL EFFECTS OF CONCOMITANT INFECTIONS
Authors: Louise Pearce
Journal: The Journal of Experimental Medicine (1928)

An experiment is reported in which was studied the effects of a concomitant vaccinal infection and of vaccinal immunity upon the reaction to syphilis in rabbits induced by intracutaneous inoculation. The results obtained showed that the reaction was modified by both conditions. A vaccinal infection initiated at the time of syphilitic inoculation was associated with a defensive reaction of lessened efficiency, the ensuing syphilis being more severe than in control animals. A state of vaccinal immunity present at the time of syphilitic inoculation was associated with a reaction of heightened efficiency, the ensuing syphilis being very mild. These results are in harmony with those obtained in other experiments in which the intratesticular route of syphilitic inoculation was employed.
Multiple Considerations in Studying the CVA
Authors: Henry Eisenberg
Journal: JAMA (1964)

<h3>To the Editor:—</h3> The authors recognize the difficulty of distinguishing between different types of cerebrovascular accidents. At this time we have no definite information on the percentage of patients with embolism and concomitant auricular fibrillation, nor do we know the exact number of those who had spinal taps. The percentage of patients who had autopsies or cerebro-angiograms is under investigation, and this information will be published when available. The authors do not wish to engage in a controversy over the exact usage of certain terms in cerebrovascular accidents. We are aware that there may be room for improvement or change in present terminology.
Welfare reform in the United States
Authors: S. Purdy
Journal: BMJ (1996)

The relation between economic status and health is well known, although the exact factors of the equation are less certain.1 Recent work from the United States2 3 confirms British research suggesting that not only is low income associated with higher mortality and ill health but that the wider the range of income in a population the greater the impact on mortality.

US president Bill Clinton has signed a bill that will bring huge changes to the federal welfare system in the United States.4 The bill fundamentally changes the organisational framework of the delivery of welfare services. Federal welfare programmes will cease to exist, and savings will be allocated to individual states. Each state will then have the authority to determine who is entitled to benefits and what those benefits are.

However, the bill does not stop at reorganising the system. The current open ended entitlement to benefits will be …
The effect of treatment on serum levels of soluble intercellular adhesion molecules and tumour necrosis factor-receptor 1 in psoriasis.
Authors: B. Kirby, M.J. Boffa, N. Nayak, W.M. Gallatin, S. Martin, C.E.M. Griffiths
Journal: British Journal of Dermatology (2001)

Journal Article The effect of treatment on serum levels of soluble intercellular adhesion molecules and tumour necrosis factor‐receptor 1 in psoriasis Get access B. Kirby, B. Kirby Dermatopharmacology Unit, Dermatology Centre, Irving Building, University of Manchester, Hope Hospital, Salford, Manchester, M6 8HD, U.K. *ICOS Corporation, Bothell, Washington, U.S.A. †Diabetes Research Institute, Heinrich Heine University, Dusseldorf, GermanyE‐mail: christopher.griffiths@man.ac.uk Search for other works by this author on: Oxford Academic Google Scholar M.J. Boffa, M.J. Boffa Dermatopharmacology Unit, Dermatology Centre, Irving Building, University of Manchester, Hope Hospital, Salford, Manchester, M6 8HD, U.K. *ICOS Corporation, Bothell, Washington, U.S.A. †Diabetes Research Institute, Heinrich Heine University, Dusseldorf, GermanyE‐mail: christopher.griffiths@man.ac.uk Search for other works by this author on: Oxford Academic Google Scholar N. Nayak, N. Nayak Dermatopharmacology Unit, Dermatology Centre, Irving Building, University of Manchester, Hope Hospital, Salford, Manchester, M6 8HD, U.K. *ICOS Corporation, Bothell, Washington, U.S.A. †Diabetes Research Institute, Heinrich Heine University, Dusseldorf, GermanyE‐mail: christopher.griffiths@man.ac.uk Search for other works by this author on: Oxford Academic Google Scholar W.M. Gallatin, W.M. Gallatin Dermatopharmacology Unit, Dermatology Centre, Irving Building, University of Manchester, Hope Hospital, Salford, Manchester, M6 8HD, U.K. *ICOS Corporation, Bothell, Washington, U.S.A. †Diabetes Research Institute, Heinrich Heine University, Dusseldorf, GermanyE‐mail: christopher.griffiths@man.ac.uk Search for other works by this author on: Oxford Academic Google Scholar S. Martin, S. Martin Dermatopharmacology Unit, Dermatology Centre, Irving Building, University of Manchester, Hope Hospital, Salford, Manchester, M6 8HD, U.K. *ICOS Corporation, Bothell, Washington, U.S.A. †Diabetes Research Institute, Heinrich Heine University, Dusseldorf, GermanyE‐mail: christopher.griffiths@man.ac.uk Search for other works by this author on: Oxford Academic Google Scholar C.E.M. Griffiths C.E.M. Griffiths Dermatopharmacology Unit, Dermatology Centre, Irving Building, University of Manchester, Hope Hospital, Salford, Manchester, M6 8HD, U.K. *ICOS Corporation, Bothell, Washington, U.S.A. †Diabetes Research Institute, Heinrich Heine University, Dusseldorf, GermanyE‐mail: christopher.griffiths@man.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 6, 1 December 2001, Pages 1027–1028, https://doi.org/10.1046/j.1365-2133.2001.04487.x Published: 01 December 2001
Alcohol and death: the New Zealand experience
Authors: A. M Wearn
Journal: BMJ (2002)

EDITOR—As a simple measure of human nature, I suspect the initial impact of the paper by White et al on alcohol consumption and mortality will depend on the age of the reader1; as someone in the two unit a week group (by a whisker of course) I was drawn to read the article in more depth.

Although it is clear what the paper adds, it is harder to decide how it affects what …
Oseltamivir Compared With the Chinese Traditional Therapy Maxingshigan–Yinqiaosan in the Treatment of H1N1 Influenza
Authors: Chen Wang, Bin Cao, Qing-Quan Liu, Zhi-Qiang Zou, Zong-An Liang, Li Gu, Jian-Ping Dong, Li-Rong Liang, Xing-Wang Li, Ke Hu, Xue-Song He, Yan-Hua Sun, Yu An, Ting Yang, Zhi-Xin Cao, Yan-Mei Guo, Xian-Min Wen, Yu-Guang Wang, Ya-Ling Liu, Liang-Duo Jiang
Journal: Annals of Internal Medicine (2011)

This article has been corrected. The original version (PDF) is appended to this article as a supplement. Background: Observational studies from Asia suggest that maxingshigan–yinqiaosan may be effective in the treatment of acute H1N1 influenza. Objective: To compare the efficacy and safety of oseltamivir and maxingshigan–yinqiaosan in treating uncomplicated H1N1 influenza. Design: Prospective, nonblinded, randomized, controlled trial. (ClinicalTrials.gov registration number: NCT00935194) Setting: Eleven hospitals from 4 provinces in China. Patients: 410 persons aged 15 to 69 years with laboratory-confirmed H1N1 influenza. Intervention: Oseltamivir, 75 mg twice daily; maxingshigan–yinqiaosan decoction (composed of 12 Chinese herbal medicines, including honey-fried Herba Ephedrae), 200 mL 4 times daily; oseltamivir plus maxingshigan–yinqiaosan; or no intervention (control). Interventions and control were given for 5 days. Measurements: Primary outcome was time to fever resolution. Secondary outcomes included symptom scores and viral shedding determined by using real-time reverse transcriptase polymerase chain reaction. Results: Significant reductions in the estimated median time to fever resolution compared with the control group (26.0 hours [95% CI, 24.0 to 33.0 hours]) were seen with oseltamivir (34% [95% CI, 20% to 46%]; P < 0.001), maxingshigan–yinqiaosan (37% [CI, 23% to 49%]; P < 0.001), and oseltamivir plus maxingshigan–yinqiaosan (47% [CI, 35% to 56%]; P < 0.001). Time to fever resolution was reduced by 19% (CI, 0.3% to 34%; P = 0.05) with oseltamivir plus maxingshigan–yinqiaosan compared with oseltamivir. The interventions and control did not differ in terms of decrease in symptom scores (P = 0.38). Two patients who received maxingshigan–yinqiaosan reported nausea and vomiting. Limitations: Participants were young and had mild H1N1 influenza virus infection. Missing viral data precluded definitive conclusions about viral shedding. Conclusion: Oseltamivir and maxingshigan–yinqiaosan, alone and in combination, reduced time to fever resolution in patients with H1N1 influenza virus infection. These data suggest that maxingshigan–yinqiaosan may be used as an alternative treatment of H1N1 influenza virus infection. Primary Funding Source: Beijing Science and Technology Project and Beijing Nova Program.
Atopic and Non-Atopic Individuals Manifest Partly Concordant Clinical and Leukocyte Responses Following Exposure To House Dust Mite In An Antigen Challenge Chamber (ACC)
Authors: Weijing He, Nathan Harper, Andrew Carrillo, Charles Andrews, Cynthia Rather, Daniel Ramirez, Robert L. Jacobs, Sunil K. Ahuja
Journal: Journal of Allergy and Clinical Immunology (2014)
Inconsistent reporting of surrogate outcomes in randomised clinical trials: cohort study
Authors: J. L. la Cour, J. Brok, P. C. Gotzsche
Journal: BMJ (2010)

<b>Objective</b> To assess if authors of randomised clinical trials convey the fact that they have used surrogate outcomes and discussed their validity. <b>Design</b> Cohort study. <b>Setting</b> Six major general medical journals. <b>Participants</b> Randomised clinical trials published in 2005 and 2006 that used a surrogate as a primary outcome. <b>Results</b> Of 626 published randomised clinical trials, 109 (17%) used a surrogate as a primary outcome. Of these trials, 62 (57%, 95% confidence interval 47% to 67%) clearly reported that the primary outcome was a surrogate. Only 38 (35%, 26% to 45%) also discussed the validity of the surrogate. <b>Conclusion</b> Only about one third of authors of randomised clinical trials that used a surrogate as a primary outcome reported adequately on the surrogate. Better reporting is needed.