Ammonia Metabolism in Renal Failure
Authors: HARRY G. PREUSS
Journal: Annals of Internal Medicine (1966)

Article1 July 1966Ammonia Metabolism in Renal FailureHARRY G. PREUSS, M.D., BERNARD B. DAVIS, M.D., JOHN F. MAHER, M.D., F.A.C.P., BERNARD W. BISE, GEORGE E. SCHREINER, M.D., F.A.C.P.HARRY G. PREUSS, M.D., BERNARD B. DAVIS, M.D., JOHN F. MAHER, M.D., F.A.C.P., BERNARD W. BISE, GEORGE E. SCHREINER, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-1-54 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe toxic effects of ammonia upon cellular metabolism have been demonstrated in many in vitro preparations (1-4). Further, elevated arterial levels of ammonia have been associated with the various manifestations of hepatic coma (5, 6). When ingestion of nitrogenous precursors was shown to elevate blood concentrations of ammonia in cirrhotic patients, the gastrointestinal tract was implicated as a source for circulating ammonia, at least in those with hepatic dysfunction (7, 8). Much of this formation of ammonia in the gut has been attributed to the breakdown of urea by bacterial ureases (9).Despite the recent emphasis on elevated blood ammonia...References1. WORCELERECINSKA AM: Mechanism of inhibitory action of ammonia on the respiration of rat-liver mitochondria. Biochim. Biophys. Acta 65: 27, 1962. CrossrefMedlineGoogle Scholar2. RECKNAGELPOTTER ROVR: Mechanism of the ketogenic effects of ammonium chloride. J. Biol. Chem. 191: 263, 1951. CrossrefMedlineGoogle Scholar3. KREBSCOHEN HAPP: Metabolism of α-ketoglutaric acid in animal tissue. Biochem. J. 33: 1895, 1939. CrossrefMedlineGoogle Scholar4. HUNTERHIXON FEWS: Anaerobic phosphorylation due to the dismutation of α-ketoglutaric acid in the presence of ammonia. J. 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Heart J. 50: 715, 1955. CrossrefMedlineGoogle Scholar23. NIELSENLIANGCHEY OFYKWY: Effect of protein administration on ammonia levels of patients with liver disease. Amer. J. Med. Sci. 250: 121, 1965. CrossrefMedlineGoogle Scholar24. SCHREINERMAHER GEJF: The nervous system and uremia, in Uremia: The Biochemistry, Pathogenesis and Treatment. Charles C Thomas, Publishers, Springfield, Ill., 1961, p. 237. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HARRY G. PREUSS, M.D.; BERNARD B. DAVIS, M.D.; JOHN F. MAHER, M.D., F.A.C.P.; BERNARD W. BISE; GEORGE E. SCHREINER, M.D., F.A.C.P.Affiliations: Washington, D. C.From the Department of Medicine, Georgetown University School of Medicine, and the Renal and Electrolyte Division, Georgetown University Hospital, Washington, D. C.This work was supported in part by Clinical Study Unit grant FR-60, the John A. Hartford Foundation, and the Georgetown University Kidney Research Fund, Washington, D. C.Dr. Preuss is supported by Postdoctoral Fellowship grant 1-F3-18, 560-01, National Heart Institute, National Institutes of Health, Bethesda, Md.Dr. Davis is supported by Postdoctoral Fellowship grant F2-AM-23, 051, National Heart Institute, National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to John F. Maher, M.D., Department of Medicine, Georgetown University Hospital, Washington, D. C. 20007. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLabel-free carbon dots from black sesame seeds for real-time detection of ammonia vapor via optical electronic nose and density functional theory calculationChronic renal failureThe effects of α-methylglutamate on ammonium excretion and renal ammonia production in ratsFulminant hepatic failure secondary to congestive heart failureCerebral ammonia metabolism in uremiaThe acidosis of renal disease 1 July 1966Volume 65, Issue 1Page: 54-61KeywordsAmmoniaAttentionBloodFellowshipsHeart failureHospital medicineRenal failureResearch fundingUreaUreases ePublished: 1 December 2008 Issue Published: 1 July 1966 PDF downloadLoading ...