tbuckley/cabot-search huggingface dataset:
Less favorable clinical outcome after diagnostic and interventional double balloon enteroscopy in patients with suspected small-bowel bleeding?
Authors: A. Madisch, J. Schmolders, S. Brückner, D. Aust, S. Miehlke
Journal: Endoscopy (2008)

Double balloon enteroscopy (DBE) is a new endoscopic technique that allows diagnosis and therapeutic interventions of small-bowel lesions. One of the main indications for DBE is suspected small-bowel bleeding (SSBB). Data about clinical outcome after DBE are limited. The aim of the present study was to prospectively assess the short-term clinical outcome of this procedure.Of all consecutive patients undergoing DBE for various indications, follow-up results in patients with SSBB were analyzed. Standardized questionnaires were used, including assessment of gastrointestinal symptoms, especially signs of gastrointestinal bleeding, blood transfusions, demand for re-intervention, and hospitalization.Of a total of 180 DBEs performed in 124 patients during a 2-year period, SSBB was the indication in 84 patients (M/F = 46/38; mean age 63 years) who underwent a total of 111 DBEs. Of these patients 52 could be followed (mean follow-up 2 months, range 1-5 months). In this subgroup, positive findings were obtained in 30 (mostly angiodysplasia), with therapeutic interventions being performed in 18 of these patients. At follow-up, the rate of re-bleeding in patients who had undergone interventions (20%) was similar to that in patients who had not (18%).In this pilot study, DBE did not seem to have a major effect on re-bleeding. Better patient selection or modification of therapeutic regimens appears to be necessary to better utilize DBE in SSBB.
Calcium-enriched foods and bone mass growth in prepubertal girls: a randomized, double-blind, placebo-controlled trial.
Authors: J P Bonjour, A L Carrie, S Ferrari, H Clavien, D Slosman, G Theintz, R Rizzoli
Journal: Journal of Clinical Investigation (1997)

High calcium intake during childhood has been suggested to increase bone mass accrual, potentially resulting in a greater peak bone mass. Whether the effects of calcium supplementation on bone mass accrual vary from one skeletal region to another, and to what extent the level of spontaneous calcium intake may affect the magnitude of the response has, however, not yet been clearly established. In a double-blind, placebo-controlled study, 149 healthy prepubertal girls aged 7.9+/-0.1 yr (mean+/-SEM) were either allocated two food products containing 850 mg of calcium (Ca-suppl.) or not (placebo) on a daily basis for 1 yr. Areal bone mineral density (BMD), bone mineral content (BMC), and bone size were determined at six sites by dual-energy x-ray absorptiometry. The difference in BMD gain between calcium-supplemented (Ca-suppl.) and placebo was greater at radial (metaphysis and diaphysis) and femoral (neck, trochanter, and diaphyses) sites (7-12 mg/cm2 per yr) than in the lumbar spine (2 mg/cm2 per yr). The difference in BMD gains between Ca-suppl. and placebo was greatest in girls with a spontaneous calcium intake below the median of 880 mg/d. The increase in mean BMD of the 6 sites in the low-calcium consumers was accompanied by increased gains in mean BMC, bone size, and statural height. These results suggest a possible positive effect of calcium supplementation on skeletal growth at that age. In conclusion, calcium-enriched foods significantly increased bone mass accrual in prepubertal girls, with a preferential effect in the appendicular skeleton, and greater benefit at lower spontaneous calcium intake.
Human Papillomavirus Genotype Distributions: Implications for Vaccination and Cancer Screening in the United States
Authors: Cosette M. Wheeler, William C. Hunt, Nancy E. Joste, Charles R. Key, Wim G. V. Quint, Philip E. Castle
Journal: JNCI Journal of the National Cancer Institute (2009)

BackgroundLimited data are available describing human papillomavirus (HPV) genotype distributions in cervical cancer in the United States. Such studies are needed to predict how HPV vaccination and HPV-based screening will influence cervical cancer prevention.
Primary Lung Adenocarcinomas in Children and Adolescents Treated for Pediatric Malignancies
Authors: Mark L. Kayton, Mai He, Maureen F. Zakowski, Andre L. Moreira, Christopher Lau, Alexander J. Chou, Melinda Merchant, Pamela R. Merola, Leonard H. Wexler, Michael P. La Quaglia, William D. Travis, Marc Ladanyi
Journal: Journal of Thoracic Oncology (2010)
Laboratory management in Europe.
Authors: P Sewell, C E Wilde
Journal: BMJ (1979)

a remission of her psychosis, which reappeared when the drug was stopped.From this followed a trial in 13 cases of acute psychoses of varying aetiology, from which he and his team concluded that the symptoms of psychoses are attributable to hyperactivity of the beta- adrenergic system in the brain.There have been attempts at treatment with beta-blockers by other research teams, which have produced spectacular results in some hands2 and dubiety so far as schizophrenic illness is concerned in others.'Here one cannot rule out, in using such high doses, the possibility of a membrane- stabilising effect; but the doses used by Steinhert and Pugh4 were much lower.
Dysfunction of the PI3 kinase/Rap1/integrin αIIbβ3 pathway underlies ex vivo platelet hypoactivity in essential thrombocythemia
Authors: Samantha F. Moore, Roger W. Hunter, Matthew T. Harper, Joshua S. Savage, Samreen Siddiq, Sarah K. Westbury, Alastair W. Poole, Andrew D. Mumford, Ingeborg Hers
Journal: Blood (2012)
Aspartame Not Linked to Cancer
Authors: Eyassu G. Abegaz
Journal: Environmental Health Perspectives (2007)

PPARα and Effects of TCEWe would like to offer a different opinion on the ideas presented in the article by Keshava and Caldwell (2006).The authors indicated that their article summarized scientific literature published since an earlier U.S. Environmental Protection Agency (EPA) risk assessment of trichloroethylene (TCE), with an emphasis on the possible role of proliferator-activated receptor α (PPARα) agonism relevant to TCE risk assessment.Interestingly, in the section on recent data on PPARα agonism, Keshava and Caldwell failed to establish any gene expression signature relating TCE and PPARα.Keshava and Caldwell (2006) contended that it is difficult to identify a clear pattern of common gene expression changes for TCE and PPARα agonists in general.However, they did not consider numerous reports and reviews (e.g., Klaunig et al. 2003;Peters et al. 2005) illustrating that there are common and reproducible changes in gene expression associated with PPARα agonists.Further, extensive characterization has definitively demonstrated specific, direct targets of PPARα-retinoid X receptor heterodimers (reviewed by Klaunig et al. 2003).Keshava and Caldwell (2006) also did not discuss the
Abstract P3-08-08: Pattern of use of an online primary health care information resource for breast cancer survivorship education: The pink ribbon survivors network
Authors: RE Fisher, L Jensen, KA Adams
Journal: Cancer Research (2013)

Abstract Introduction: The Pink Ribbon Survivors Network, a 501(c)(3) nonprofit organization founded by cancer professionals, developed an online educational resource for breast cancer survivors, cancer care professionals, and primary health care providers. The organization created a separate online educational library for each of these three separate audiences. The organization's website launched in July, 2012. Methods: The Primary Health Care Library for breast cancer survivorship education houses 15 unique categories. Utilizing the organization's administrative website, numerical pattern of access of each separate listing in the 15 categories can be obtained. In addition, Google Analytics data was utilized to determine total website activity for all three educational libraries. Results: As of abstract submission, the Primary Healthcare Breast Cancer Survivorship Education Library contains 141 clinical articles in 15 categories. The website has been utilized in all 50 of the United States, and in 66 countries and 890 cities. The five most viewed categories of the 15 total categories are (in descending order): 1.) Lifestyle Modifications, 2.) Creating a Link between Cancer Care and Primary Care: Clinical Literature on Survivorship, 3.) Depression/Mood Disturbance, 4.) Consensus Panel Guidelines for Breast Cancer Follow up, and 5.) Gynecologic Issues: Sexuality/Fertility. Conclusion: Since it's creation in mid- 2012, an online breast cancer survivorship resource is being utilized for educational review. Users of the website are preferentially interested in QOL, healthcare system, and Consensus guidance in their educational viewing. This system can be utilized to disseminate nationally recognized clinical advice for Primary Healthcare Providers as they care for breast cancer survivors in their routine healthcare practices. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P3-08-08.
Acute Pulmonary Edema Due to Aspiration of Gastric Juice
Authors: W. W. Jetter
Journal: New England Journal of Medicine (1951)

ACUTE PULMONARY EDEMA DUE TO ASPIRATION OF GASTRIC JUICERegurgitation and aspiration of stomach contents may cause serious complications in old and infirm patients, in those who are unconscious, regardless of the cause, and in those suffering from some abnormality of deglutition. Suffocation incident to massive aspiration may lead to acute asphyxial death. If the amount aspirated has been smaller, pulmonary abscesses, bronchiectasis, pneumonia or atelectasis may result. These are well recognized complications. One that is relatively unrecognized is chemical pneumonitis from aspiration of gastric juice per se without other foreign material.1 Symptoms appear after a latent period of several . . .
Handbook of Nutrition and Ophthalmology
Authors: Douglas Kalman, Diane R. Krieger
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cystic intrathoracic derivatives of the foregut and their complications
Authors: W. O. Kirwan, P. R. Walbaum, R. J. M. McCormack
Journal: Thorax (1973)

It is suggested that these lesions should be classified into three main categories based on embryology—bronchogenic cyst (resulting from a defect of lung budding), intramural oesophageal cyst (true duplication), and enteric cyst (resulting from the split notochord syndrome). A series of 41 patients is reported. Seven of our patients suffered complications, and in two cases these nearly resulted in the death of the patient. These complications are described and their serious import is used to emphasize the desirability of surgical removal of all these foregut derivatives before complications ensue.
Commentary: Randomised trials of surgical and non-surgical treatment: a role model for the future
Authors: J. M Blazeby, C P. Barham, J. L Donovan
Journal: BMJ (2008)

Symptoms of acid reflux and heartburn are increasingly common, and doctors need to understand the benefits and risks of surgical and medical treatment from the patients’ perspective when offering treatment. Obtaining reliable information from randomised controlled trials to fully inform patients is difficult, however, because of the many recognised obstacles to undertaking such trials of diverse treatments, including difficulties with recruitment and standardising treatments and the inability to provide blinding. In the linked study (doi:10.1136/bmj.a2664), Grant et al carried out a multicentre pragmatic randomised trial of minimal access surgery (laparoscopic fundoplication) compared with optimised medical management (standard proton pump inhibition) for chronic gastro-oesophageal reflux disease (GORD).1 The results were clear: up to 12 months after starting treatment, surgery was …
TCT-643 Very Late Stent Thrombosis after Revascularization with Biolimus-Eluting Biodegradable Polymer-Coated Nobori Stent versus Durable Polymer-Coated Sirolimus-Eluting Stents from the SORT OUT V Trial
Authors: Evald H. Christiansen, Lisette Okkels Jensen, Per Thayssen, Hans-Henrik Tilsted, Lars Krusell, Anne Kaltoft, Michael Maeng, Jan Ravkilde, Jens F. Lassen
Journal: Journal of the American College of Cardiology (2014)
Monoacylation of ribonuclease A enables its transport across an in vitro model of the blood–brain barrier
Authors: Joël Chopineau, Stéphane Robert, Laurence Fénart, Roméo Cecchelli, Bernard Lagoutte, Stéphanie Paitier, Marie-Pierre Dehouck, Dominique Domurado
Journal: Journal of Controlled Release (1998)
Amount of Nicotine and Carbon Monoxide Inhaled by Smokers of Low-Tar, Low-Nicotine Cigarettes
Authors: Richard V. Ebert
Journal: JAMA (1983)

In 76 smokers, correlations between plasma nicotine and alveolar carbon monoxide levels of the individual smoker and the nicotine and CO yields of his cigarette were very poor. In 24 smokers of low-nicotine, low-tar cigarettes, mean alveolar CO levels did not differ from those of smokers of regular cigarettes. Mean plasma nicotine levels were lower in smokers of low-nicotine cigarettes, but a wide overlap of individual values occurred. The implication that an individual shifting to ultra-low-tar cigarettes reduces risks of cardiopulmonary disease is unwarranted. (<i>JAMA</i>1983;250:2840-2842)
Vitamins During Pregnancy and Neural Tube Defects
Authors: Samuel Shapiro
Journal: JAMA (1990)

<h3>To the Editor.—</h3> In their discussion of the apparent protective effect of multivitamin/folic acid supplements on the risk of neural tube defects (NTDs), Milunsky et al<sup>1</sup>claim that "the timing of the interviews in early pregnancy and the fact that the vast majority of mothers were unaware of pregnancy outcome minimized the possibility that this finding was due to their selective participation or biased recall of supplementation." With regard to selective participation, all women were recruited from those whose α-fetoprotein or amniocentesis samples were submitted to the authors or their colleagues. However, unless<i>all</i>samples (or a random sample) from each participating center were included, the possibility of selection bias cannot be excluded. Such a bias becomes a strong possibility for the 19% of amniocentesis samples analyzed elsewhere, since those women may have been referred preferentially when their samples yielded a diagnosis of NTD and there was no history
Childhood Height and Body Mass Index Were Associated with Risk of Adult Thyroid Cancer in a Large Cohort Study
Authors: Cari M. Kitahara, Michael Gamborg, Amy Berrington de González, Thorkild I.A. Sørensen, Jennifer L. Baker
Journal: Cancer Research (2013)

Abstract Taller stature and obesity in adulthood have been consistently associated with an increased risk of thyroid cancer, but few studies have investigated the role of childhood body size. Using data from a large prospective cohort, we examined associations for height and body mass index (BMI) at ages 7 to 13 years with risk of thyroid cancer in later life. The study population included 321,085 children from the Copenhagen School Health Records Register, born between 1930 and 1989 in Copenhagen, Denmark, with measurements of height and weight from 7 to 13 years of age. These data were linked with the Danish Cancer Registry to identify incident thyroid cancer cases (1968–2010). Hazard ratios (HR) and 95% confidence intervals (CI) were calculated for age- and sex-specific height and BMI SD scores (SDS) using proportional hazards models stratified by birth cohort and sex. During follow-up (median = 38.6 years), 171 women and 64 men were diagnosed with thyroid cancer. Both height and BMI were positively associated with thyroid cancer risk, and these associations were similar by age at measurement. Using age 10 as an example, HRs per 1 unit increase in SDS for height (∼6–7 cm) and BMI (∼ 1.5–2 kg/m2) were 1.22 (95% CI, 1.07–1.40) and 1.15 (95% CI, 1.00–1.34), respectively. These results, together with the relatively young ages at which thyroid cancers are diagnosed compared with other malignancies, suggest a potential link between early-life factors related to growth and body weight and thyroid carcinogenesis. Cancer Res; 74(1); 235–42. ©2013 AACR.
Mitral Insufficiency: Cardiac Mechanics as Studied with the Kinetocardiogram and Ballistocardiogram
Authors: WILLIAM T. TUCKER, JOHN L. KNOWLES, E. E. EDDLEMAN
Journal: Circulation (1955)

Precordial movements (kinetocardiograms) and ballistocardiograms were studied in patients with "pure" mitral insufficiency. Certain characteristic features of the records were noted and contrasted with those found in patients with mitral stenosis. The finding suggests fundamental differences in the mode of ventricular contraction and relaxation in mitral insufficiency and mitral stenosis.
Cetuximab Response of Lung Cancer–Derived EGF Receptor Mutants Is Associated with Asymmetric Dimerization
Authors: Jeonghee Cho, Liang Chen, Naveen Sangji, Takafumi Okabe, Kimio Yonesaka, Joshua M. Francis, Richard J. Flavin, William Johnson, Jihyun Kwon, Soyoung Yu, Heidi Greulich, Bruce E. Johnson, Michael J. Eck, Pasi A. Jänne, Kwok-Kin Wong, Matthew Meyerson
Journal: Cancer Research (2013)

Abstract Kinase domain mutations of the EGF receptor (EGFR) are common oncogenic events in lung adenocarcinoma. Here, we explore the dependency upon asymmetric dimerization of the kinase domain for activation of lung cancer–derived EGFR mutants. We show that whereas wild-type EGFR and the L858R mutant require dimerization for activation and oncogenic transformation, the exon 19 deletion, exon 20 insertion, and L858R/T790M EGFR mutants do not require dimerization. In addition, treatment with the monoclonal antibody, cetuximab, shrinks mouse lung tumors induced by the dimerization-dependent L858R mutant, but exerts only a modest effect on tumors driven by dimerization-independent EGFR mutants. These data imply that different EGFR mutants show differential requirements for dimerization and that disruption of dimerization may be among the antitumor mechanisms of cetuximab. Cancer Res; 73(22); 6770–9. ©2013 AACR.
PREVALENCE AND IMPACT OF RENAL FAILURE IN OCTOGENARIANS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION
Authors: Jean-Pierre Dery, Helena Tizon-Marcos, Pierre-Louis Bernard, Julie Plaisance, Cindy Boulanger-Gobeil, Josep Rodés-Cabau, Gerald Barbeau, Eric Larose, Stephane Rinfret, Can M. Nguyen, Onil Gleeton, Guy Proulx, Bernard Noël, Louis Roy, Robert Delarochellière, Olivier F. Bertrand
Journal: Journal of the American College of Cardiology (2010)
Polly Amanda James
Authors: Matt Bull
Journal: BMJ (2007)

<h3>INTRODUCTION:</h3> There is growing evidence that exercise-induced variation in lung volumes is an important source of ventilatory limitation and is linked to exercise intolerance in COPD. The aim of this study was to compare the correlations of walk distance and lung volumes measured before and after a 6-min walk test (6MWT) in subjects with COPD. <h3>METHODS:</h3> Forty-five subjects with stable COPD (mean pre-bronchodilator FEV<sub>1</sub>: 47 ± 18% predicted) underwent a 6MWT. Body plethysmography was performed immediately pre- and post-6MWT. <h3>RESULTS:</h3> Correlations were generally stronger between 6-min walk distance and post-6MWT lung volumes than between 6-min walk distance and pre-6MWT lung volumes, except for FEV<sub>1</sub>. These differences in Pearson correlation coefficients were significant for residual volume expressed as percent of total lung capacity (-0.67 vs -0.58, <i>P</i> = .043), percent of predicted residual volume expressed as percent of total lung capacity (-0.68 vs -0.59, <i>P</i> = .026), inspiratory vital capacity (0.65 vs 0.54, <i>P</i> = .019), percent of predicted inspiratory vital capacity (0.49 vs 0.38, <i>P</i> = .037), and percent of predicted functional residual capacity (-0.62 vs -0.47, <i>P</i> = .023). <h3>CONCLUSIONS:</h3> In subjects with stable COPD, lung volumes measured immediately after 6MWT are more closely related to exercise limitation than baseline lung volumes measured before 6MWT, except for FEV<sub>1</sub>. Therefore, pulmonary function testing immediately after exercise should be included in future studies on COPD for the assessment of exercise-induced ventilatory constraints to physical performance that cannot be adequately assessed from baseline pulmonary function testing at rest.
On the Best Method of Examining the Auditory Apparatus
Authors: P. Meniere
Journal: BMJ (1841)

the dressings in these cases should be applied cold, and be of the mildest kind; dry lint will sometimes inflame much; the epulotic cerate is a very good application; lapis calimanaris has no. thing irritating in its properties. Opium is per haps the best application to stop ulceration, vhich in those cases is very frequent. Bark should be given internally, which is particularly useful in removing irritability and restoring health.
Mild Nitrogen Narcosis?
Authors: E. C. Poulton, A. Carpenter, M. J. Catton
Journal: BMJ (1963)

AMYLOIDOSIS JB Case 3The patient, a woman of 49, complained of a lump in the left axilla which had been increasing in size for a year.Her general health was good but her right leg had been amputated below the knee after an accident.At operation a lump 6 by 4 cm.was found attached to a chain of smaller lumps suggestive of enlarged lymph nodes.All these swellings were red or yellowish red in colour and soft in consistency.Histology showed small collections of lymphocytes widely scattered among eosinophilic anuclear material (Fig. 3).The possibility of amyloidosis was considered, but special stains gave inconclusive results.Thioflavine-T was not used on this occasion.The patient made an uneventful recovery.Ten months later similar lumps appeared in the same axilla.At this time haematological investigations were normal.X-ray examination of the chest, an intravenous pyelogram, and serum protein investigations, including electrophoresis, were within normal limits.Histological examination of the lumps showed appearances identical with those seen previously.Special stains, however, including thioflavine-T, confirmed that the eesinophilic material was amyloid (Fig. 4).A congo-red test had not been performed, but a rectal biopsy showed no evidence of amyl- oidosis.The patient remains in good general health.# ~~~~~~~~~~!Flo. 3-Case 3. Amyloid deposition in lymph node. (Haemat- oxylin and eosin.x 125.)