Turnover of<sup>131</sup>I-labeled Autologous Macroglobulin in Waldenström's Macroglobulinemia
Authors: PATRICIA WILKINSON
Journal: Annals of Internal Medicine (1966)

Case Studies1 August 1966Turnover of 131I-labeled Autologous Macroglobulin in Waldenström's MacroglobulinemiaReport of a Case Studied During Treatment with Phenylalanine MustardPATRICIA WILKINSON, M.D., F.R.C.P., WARREN DAVIDSON, M.D., AMORY SOMMARIPA, M.D.PATRICIA WILKINSON, M.D., F.R.C.P.Search for more papers by this author, WARREN DAVIDSON, M.D.Search for more papers by this author, AMORY SOMMARIPA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-2-308 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn Waldenström's macroglobulinemia (1) turnover of the patient's own abnormal macroglobulin has been measured only in untreated patients (2-5) or in patients who have been plasmapheresed (5). There are no reports of turnover of anomalous macroglobulin after cytotoxic therapy. We were recently able to measure the turnover of the abnormal macroglobulin after labeling it with131I in a patient with Waldenström's macroglobulinemia who was receiving phenylalanine mustard. Although we were unable to study him before therapy, it seemed worthwhile to investigate his turnover of macroglobulin when remission had been obtained with the drug, in the hope of learning more about...References1. WALDENSTRÖM J: Incipient myelomatosis or "essential" hyperglobulinemia with fibrinogenopenia—a new syndrome? Acta Med. Scand. 117: 216, 1944. CrossrefGoogle Scholar2. DRIVSHOLM A: Turnover rate of myeloma proteins in serum and urine determined after intravital labelling with glycine-1-C-14. Acta Med. Scand. 169: 503, 1961. CrossrefMedlineGoogle Scholar3. GABUZDA TG: The turnover and distribution of I131-labelled myeloma and macroglobulin proteins. J. Lab. Clin. Med. 59: 65, 1962. MedlineGoogle Scholar4. OLESEN H: Turnover studies with iodine-labelled gamma-macroglobulin and albumin. Scand. J. Clin. Lab. Invest. 15: 497, 1963. CrossrefMedlineGoogle Scholar5. BARTHWOCHNERWALDMANNFAHEY WFRDTAJL: Metabolism of human gamma macroglobulins. J. Clin. Invest. 43: 1036, 1964. CrossrefMedlineGoogle Scholar6. MCFARLANE AS: Efficient trace-labelling of proteins with iodine. Nature (London) 182: 53, 1958. CrossrefMedlineGoogle Scholar7. CAMPBELLCUTHBERTSONMATTHEWSMCFARLANE RMDPCMAS: Behavior of 14C and 131I-labelled plasma proteins in the rat. Int. J. Appl. Radiat. 1: 66, 1956. CrossrefMedlineGoogle Scholar8. STERLING K: Turnover rate of serum albumin in man as measured by 131I-tagged albumin. J. Clin. Invest. 30: 1228, 1951. CrossrefMedlineGoogle Scholar9. FREEMANMATTHEWS TCM: Analysis of the behaviour of I131-albumin in the normal subject and nephrotic patient. Stralen Therapie, Sunderband 38. Radioactive Isotope in Klinik and Forshung 3: 283, 1958. Google Scholar10. MCFARLANE AS: Labelling of plasma proteins with radioactive iodine. Biochem. J. 62: 135, 1956. CrossrefMedlineGoogle Scholar11. COHENFREEMAN ST: Metabolic heterogeneity of human γ-globulin. Biochem. J. 76: 475, 1960. CrossrefMedlineGoogle Scholar12. BENNHOLDKALLEE HE: Comparative studies on the half-life of I131-labelled albumins and non-radioactive human serum albumin in a case of analbuminemia. J. Clin. Invest. 38: 863, 1959. CrossrefMedlineGoogle Scholar13. WILKINSONMENDENHALL PCL: Serum albumin turnover in normal subjects and patients with cirrhosis measured by 131I-labelled human albumin. Clin. Sci. 25: 281, 1963. MedlineGoogle Scholar14. FAHEYROBINSON JLAG: Factors controlling serum gamma-globulin concentration. J. Exp. Med. 118: 845, 1963. CrossrefMedlineGoogle Scholar15. SOLOMONFAHEY AJL: Plasmapheresis therapy in macroglobulinemia. Ann. Intern. Med. 58: 789, 1963. LinkGoogle Scholar16. RITZMANNCOLEMANLEVIN SESLWC: The effect of some mercaptanes upon a macrocryogelglobulin; modifications induced by cysteamine, penicillamine and penicillin. J. Clin. Invest. 39: 1320, 1960. CrossrefMedlineGoogle Scholar17. BLOCHPRASADANASTASIBRIGGS HSAADR: Serum protein changes in Waldenström's macroglobulinemia during administration of a low molecular weight thiol (penicillamine). J. Lab. Clin. Med. 56: 212, 1960. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PATRICIA WILKINSON, M.D., F.R.C.P.; WARREN DAVIDSON, M.D.; AMORY SOMMARIPA, M.D.Affiliations: Philadelphia, PennsylvaniaFrom the Medicine Service of Philadelphia General Hospital and the University of Pennsylvania, Philadelphia, Pa.This work was supported in part by training grant AM05415, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Amory M. Sommaripa, M.D., 1 Summit St., Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIgM Turnover in ManVertigo in the Hyperviscosity SyndromeInfluence of blood viscosity on cochlear action potentials and oxygenationThe rǒle of plasma proteins in chronic expansion of plasma volume in tropical splenomegaly syndrome I. Metabolism of 131I-labelled albuminCutaneous signs of cryoparaproteinemia: Control with burst alkeran and prednisoneThe Pathology Of Sudden DeafnessIgM Turnover in Chronic Liver DiseaseMETABOLISM OF NORMAL γ M-GLOBULIN IN NORMALSTHE TURNOVER OF COLD AGGLUTININ AND ITS SPLIT PRODUCTSMetabolism of Human γ-Macroglobulin (IgM) in Normal ManThe tropical splenomegaly syndrome 1 August 1966Volume 65, Issue 2Page: 308-316KeywordsBlood plasmaBone marrowDrug therapyExcretionHospital medicineMedical servicesPhenylalaninePlasma proteinsProteinsUltracentrifugation ePublished: 1 December 2008 Issue Published: 1 August 1966 PDF downloadLoading ...