tbuckley/cabot-search huggingface dataset:
DIPHTHERITIC VULVOVAGINITIS AND DIPHTHERIA OF THE SKIN, MOUTH AND THROAT
Authors: Roy H. Cantrell
Journal: JAMA (1934)

This case of diphtheritic vulvovaginitis and diphtheria of the skin is being reported because of the rarity of its occurrence. The material on the subject in the available American literature is quite limited. Shrewsbury<sup>1</sup>reports a case of cutaneous infection of the thigh with a diphtheroid bacillus, identical with the Klebs-Löffler bacillus in every respect except in toxin production. This lesion healed in three weeks, only after curettage and iodoform dressings. Anderson<sup>2</sup>describes a case of gangrene of the skin, due to diphtheria. Warren and Sutton<sup>3</sup>contribute a fatal case of diphtheria of the skin, superimposed on varicella. Massey and Russell<sup>4</sup>record a case of diphtheria of the skin which was the cause of an outbreak of diphtheria. Montgomery<sup>5</sup>mentions a case of diphtheria of the skin about the umbilicus, in which the umbilicus of a baby 7 days old was the site of primary
Low frequency clonal mutations recoverable by deep sequencing in patients with aplastic anemia
Authors: Andrew A. Lane, Oreofe Odejide, Nadja Kopp, Sunhee Kim, Akinori Yoda, Rachel Erlich, Nikhil Wagle, Gregory A. Abel, Scott J. Rodig, Joseph H. Antin, David M. Weinstock
Journal: Leukemia (2013)
Felodipine versus Hydrochlorothiazide as an Addition to a β-Blocker in the Treatment of Hypertension
Authors: H. Borgmästars, B. Forsén, J. Tuomilehto, R. Hellebø, P. O. Walle, H. M. Nielsen, E. Nielsen, O. Winkel, E. Steiness, H. Ibsen
Journal: Drugs (1987)
Impaired Pulmonary Diffusion During Exercise in Patients With Chronic Heart Failure
Authors: Alan A. Smith, Peter J. Cowburn, Matthew E. Parker, Martin Denvir, Sundeep Puri, Kanti R. Patel, John G. F. Cleland
Journal: Circulation (1999)

Background —Pulmonary diffusion is impaired at rest in patients with chronic heart failure (CHF) and has been implicated in the generation of symptoms and exercise intolerance. The aim of this study was to determine whether pulmonary diffusion is impaired during exercise in CHF, to examine its relationship to pulmonary blood flow, and to consider its functional significance in relation to metabolic gas exchange. Methods and Results —Carbon monoxide transfer factor (TLCO) and pulmonary blood flow (Q C ) were measured by a rebreathe technique at rest and during steady-state cycling at 30 W in 24 CHF patients and 10 control subjects. Both patients and control subjects were able to raise TLCO and Q C during exercise. However, the patient group had a lower diffusion for a given blood flow (TLCO/Q C ) both at rest (3.6±0.16 and 4.8±0.23 mL · L −1 · mm Hg −1 ; P &lt;0.001) and during exercise (2.8±0.16 and 3.4±0.13 mL · L −1 · mm Hg −1 for CHF patients and control subjects, respectively; P &lt;0.05). TLCO/Q C was related to the ventilatory equivalent for carbon dioxide (VEVCO 2 ) production at 30 W (TLCO/Q c versus VEVCO 2 , r =−0.58, P &lt;0.01) and to peak exercise oxygen consumption measured during a progressive test (TLCO/Qc versus V o 2peak , r =0.57, P &lt;0.01) in these patients. Conclusions —Patients with CHF are able to recruit reserves of TLCO and Q C during exercise. However, the TLCO/Q C ratio is consistently impaired in these patients and relates to both exercise hyperpnea and peak exercise oxygen consumption. Whether this impairment in alveolar gas exchange is reversible in CHF and therefore is a potential target for therapy has yet to be determined.
Insights into native epitopes of proliferating cell nuclear antigen using recombinant DNA protein products.
Authors: J P Huff, G Roos, C L Peebles, R Houghten, K F Sullivan, E M Tan
Journal: The Journal of Experimental Medicine (1990)

A cDNA clone encoding full-length human proliferating cell nuclear antigen (PCNA) was used to generate a panel of in vitro translated labeled protein products with COOH-terminal deletions and to construct a set of fusion proteins with COOH- and NH2-terminal deletions. A rabbit antiserum raised against an NH2-terminal peptide, a well-characterized murine monoclonal antibody (mAb), and 14 human lupus sera with autoantibody to PCNA were analyzed for their reactivity with the constructs using both immunoprecipitation and immunoblotting techniques. The rabbit antiserum reacted in immunoprecipitation and immunoblotting with constructs containing the appropriate NH2-terminal sequence and mAb reacted with a sequence from the midregion of PCNA. These experimentally induced antibodies also reacted with 15-mer synthetic peptides in enzyme-linked immunosorbent assay (ELISA). In contrast, none of the lupus sera reacted with synthetic peptides in ELISA. 9 of the 14 lupus sera also failed to react in Western immunoblotting with any recombinant fusion protein, although they all immunoprecipitated in vitro translated full-length protein. Four of the nine had variable patterns of immunoprecipitation with shorter constructs. The remaining five lupus sera were able to immunoprecipitate translation products as well as Western blot recombinant fusion proteins. From analysis of the patterns of reactivity of human lupus sera, it was deduced that the apparent heterogeneity of human autoantibodies to PCNA could be explained by immune response to highly conformational epitopes. These observations demonstrate that there might be special features in "native" epitopes of intranuclear antigens that are recognized by autoantibodies, and that these special features of native epitopes might not be present in prepared antigen used for experimental immunization. These features may be related to protein folding or to association of the antigen with other intranuclear proteins or nucleic acids, as might occur with antigens that are components of subcellular particles.
Non-penetrance and late appearance of polyps in families with familial adenomatous polyposis.
Authors: D G Evans, S P Guy, N Thakker, J G Armstrong, C Dodd, D R Davies, C Babbs, T Clancy, T Warnes, P Sloan
Journal: Gut (1993)

One case of non-penetrance of the familial adenomatous polyposis (FAP) gene at 59 years of age and late onset of polyps on endoscopy and biopsy in this and two other families is described. Screening protocols should include dental screening as well as indirect ophthalmoscopy and endoscopy to detect minimal manifestations of the gene. In the absence of a specific DNA predictive test, bowel screening should continue well beyond 30 years of age.
Abstract 5483: Implications of the type of <i>BRCA1</i> germline mutation in the treatment of patients with hereditary breast cancer
Authors: Tereza Vaclova, Nicholas T. Woods, Fernando Setién, José María García Bueno, José Antonio Macías, Alicia Barroso, Miguel Urioste, Manel Esteller, Alvaro N.A. Monteiro, Javier Benítez, Ana Osorio
Journal: Cancer Research (2014)

Abstract Carrying an inherited mutation in BRCA1 or BRCA2 genes significantly increases individual´s lifetime risk to develop breast or ovarian cancer. However, there are considerable differences in disease manifestation among mutation carriers, suggesting the existence of other factors which could modify the risk of cancer development. Since BRCA1 is an important component of DNA repair, BRCA1-deficient cells have to rely on other members of the DNA repair machinery. This makes them sensitive to drugs which target specific repair pathways, such as inhibitors of poly (ADP-ribose) polymerase (PARP). Several PARP inhibitors are currently being tested in preclinical or clinical trials, either as a monotherapy or in combination with chemo- or radiotherapy. Taking into account the promising results in patients with germline mutation in BRCA1 or BRCA2 genes, we aimed to investigate which BRCA1 mutation carriers, depending on the mutation type, might benefit from treatment with PARP inhibitors the most. In addition, we were also interested in identifying markers of sensitivity/resistance to PARP inhibitors. We have used lymphoblastoid cell lines (LCLs) derived from lymphocytes of healthy women heterozygous for different BRCA1 mutations and healthy women from the same families with no mutation. In total, 23 LCLs were characterized according to their DNA repair capacity, growth rate, gene/miRNA expression and sensitivity to PARP inhibitors. Our preliminary results have shown significantly higher sensitivity to PARP inhibitor olaparib in cells harbouring missense mutation in comparison to cells with truncating or no mutation. The ongoing functional studies on these BRCA1 missense variants indicate that these mutations could act in a dominant negative manner. Importantly, the observed differences in sensitivity to olaparib among mutation carriers could be also relevant for recently proposed use of PARP inhibitors as prophylactic agent for mutation carriers. Our ongoing work may help us to better understand the mechanisms of action of PARP inhibitors and lead to improvement of therapeutic strategies for BRCA1-associated cancers with extension to other tumors. Citation Format: Tereza Vaclova, Nicholas T. Woods, Fernando Setién, José María García Bueno, José Antonio Macías, Alicia Barroso, Miguel Urioste, Manel Esteller, Alvaro N.A. Monteiro, Javier Benítez, Ana Osorio. Implications of the type of BRCA1 germline mutation in the treatment of patients with hereditary breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5483. doi:10.1158/1538-7445.AM2014-5483
790 PLASMA SOLUBLE ST2 RECEPTOR IS INCREASED IN HUMAN ALCOHOLIC LIVER DISEASE AND CORRELATES WITH THE PROGNOSTIC INDEX IN ALCOHOLIC HEPATITIS
Authors: A. Lemmers, C. Moreno, R. Ouziel, D. Degré, E. Trepo, E. Quertinmont, V. Vercruysse, O. Le Moine, J. Devière, T. Gustot
Journal: Journal of Hepatology (2010)
Growth and Motility Inhibition of Breast Cancer Cells by Epidermal Growth Factor Receptor Degradation Is Correlated with Inactivation of Cdc42
Authors: Dianne S. Hirsch, Yi Shen, Wen Jin Wu
Journal: Cancer Research (2006)

Overexpression of epidermal growth factor receptor (EGFR) contributes to increased cell proliferation and migration in breast cancer. However, mechanisms of EGFR overexpression remain elusive and often cannot be attributed to gene amplification. In NIH3T3 fibroblasts, active Cdc42 inhibits c-Cbl-regulated EGFR degradation to induce cellular transformation. Here, we use two EGFR-overexpressing breast cancer cell lines, MDA-MB-231 and BT20, as models to test the hypothesis that up-regulated Cdc42 activity impairs c-Cbl-mediated EGFR degradation and contributes to EGFR overexpression. We show that silencing Cdc42 significantly reduces protein levels of EGFR, leading to a marked reduction in cell proliferation and migration, and c-Cbl knockdown increases the levels of EGFR. Expression of c-Cbl-N480, a c-Cbl mutant that is not regulated by Cdc42 and blocks Cdc42-induced transformation but still binds and ubiquitinates EGFR, enhances the rate of EGFR degradation and subsequently inhibits cell proliferation. Moreover, down-regulated EGFR signaling induced by c-Cbl-N480 decreased activity of Cdc42 and Rac1, resulting in inhibition of cell migration. These findings indicate that Cdc42 and c-Cbl are critical components involved in the regulation of EGFR protein levels and that restoration of proper EGFR degradation by disrupting Cdc42 regulation of c-Cbl can reduce cell proliferation and migration in MDA-MB-231 and BT20 cells.
X-Ray Diagnosis for Clinical Students and Practitioners
Authors: Luther W. Brady
Journal: JAMA (1968)

In the development of a teaching program in diagnostic radiology, it is necessary for the medical student to have available systematic instruction in radiographic anatomy in his preclinical training, and this should extend into the training period in clinical medicine. On such a background provided by both radiologists and anatomists, clinical diagnostic radiology can be more effectively taught and its place as an aid to clinical diagnosis firmly established. The author has written a book primarily for the medical student during his period of clinical training and one that would have applicability to house officers and physicians in their early days of practice. The author does not intend to cover all aspects of radiology but he contributes toward the problem of incorporating the teaching of radiology into the general clinical curriculum. The author's experience was primarily the source for material in the volume, which deals with the indications, value, and
An uncommon cause of finger drop in a patient with rheumatoid arthritis.
Authors: S P McDonald, M D Smith
Journal: Annals of the Rheumatic Diseases (1996)

Case reportA 72 year old man with a four year history of seropositive rheumatoid arthritis had been treated with intramuscular and oral gold and methotrexate in the past, all of which were stopped because of toxicity.Despite previous poor disease control with hydroxychloroquine he had declined other disease modifying agents.There was no other significant medical history.He presented with sudden onset of left shoulder and arm pain while reaching up with the left upper arm.Hours later he noted mild swelling and paraesthesiae in his left hand, and difficulty using the fingers of the hand.Examination of his shoulder showed anterosu- perior subluxation of the humeral head, with severe restriction of all active and passive movements.There was an active left elbow synovitis with a moderate joint effusion.There was no weakness of the biceps or triceps mus- cles.Supination appeared to be slightly weak, but was difficult to assess initially due to elbow pain.Finger and thumb extension was absent but thumb abduction was intact.Wrist extension was weak, with radial deviation.Sen- sation was intact to all modes in the left upper limb.Initial diagnoses attempted to link the shoul- der and hand signs, and included a possible acute rotator cuff rupture with brachial plexus injury or reflex sympathetic dystrophy.An urgent shoulder arthrogram showed no
Immediate Death after Intravenous Injection of Iodoxyl
Authors: G. S. Ramsay
Journal: BMJ (1953)

BEDIBm 43UR9 Macfarlane and Currie (1943) described a case occurring in a woman aged 22 who died of fatal pyrexia following a blood transfusion.Rinvik (1941-2) described two cases in infants between 2 and 3 months who were kept alive for long periods by blood transfusions.Robson and Sweeney (1948) described a case of red-cell aplasia arising in a child of 18 months.Smith (1949) refers to the condition as chronic congenital aregenerative anaemia.He postulates prolonged depression of the red-cell elements of the marrow by an antibody formed during foetal life.This antibody is thought to be due to ABO incompatibility between mother and child- for example, the infant's group being A and the mother's 0. The history of jaundice shortly after birth would make this theory attractive in our case, but the patient's being Group 0 militated against the hypothesis.Further test showed no incompatibility between the child's cells and the mother's serum.
Mars or Venus — Is Sex a Risk Factor for Recurrent Venous Thromboembolism?
Authors: C. Gregory Elliott, Lewis J. Rubin
Journal: New England Journal of Medicine (2004)

In 1856 Rudolph Virchow identified three primary risk factors — commonly called Virchow's triad — for venous thromboembolism: venous stasis, hypercoagulability, and endothelial injury.1 Other risk factors have since been added to the list, and quantitative assessments now allow the classification of these factors as major (e.g., surgery) or minor (e.g., oral-contraceptive use).2 Although the patient's sex has not been implicated as an inherent risk factor for a first episode of venous thromboembolism, pregnancy and the use of estrogen-containing oral contraceptives are recognized sex-specific factors.The identification of risk factors is pivotal in the management of a first episode of . . .
A Comparative Study of Molecular Characteristics of Diffuse Large B-cell Lymphoma from Patients with and without Human Immunodeficiency Virus Infection
Authors: Chun Chao, Michael J. Silverberg, Lanfang Xu, Lie-Hong Chen, Brandon Castor, Otoniel Martínez-Maza, Donald I. Abrams, Hongbin D. Zha, Reina Haque, Jonathan Said
Journal: Clinical Cancer Research (2015)

HIV-related diffuse large B-cell lymphoma (DLBCL) may be biologically different from DLBCL in the general population. We compared, by HIV status, the expression and prognostic significance of selected oncogenic markers in DLBCL diagnosed at Kaiser Permanente in California, between 1996 and 2007.Eighty HIV-infected DLBCL patients were 1:1 matched to 80 HIV-uninfected DLBCL patients by age, gender, and race. Twenty-three markers in the following categories were examined using IHC: (i) cell-cycle regulators, (ii) B-cell activators, (iii) antiapoptotic proteins, and (iv) others, such as IgM. Tumor marker expression was compared across HIV infection status by Fisher exact test. For markers differentially expressed in HIV-related DLBCL, logistic regression was used to evaluate the association between tumor marker expression and 2-year overall mortality, adjusting for International Prognostic Index, cell-of-origin phenotype, and DLBCL morphologic variants.Expression of cMYC (% positive in HIV-related and -unrelated DLBCL: 64% vs. 32%), BCL6 (45% vs. 10%), PKC-β2 (61% vs. 4%), MUM1 (59% vs. 14%), and CD44 (87% vs. 56%) was significantly elevated in HIV-related DLBCLs, whereas expression of p27 (39% vs. 75%) was significantly reduced. Of these, cMYC expression was independently associated with increased 2-year mortality in HIV-infected patients [relative risk = 3.09 (0.90-10.55)] in multivariable logistic regression.These results suggest that HIV-related DLBCL pathogenesis more frequently involves cMYC and BCL6 among other factors. In particular, cMYC-mediated pathogenesis may partly explain the more aggressive clinical course of DLBCL in HIV-infected patients.
THE DETECTION AND INCIDENCE OF HUMAN INTESTINAL PROTOZOA BY THE SIGMOIDOSCOPE
Authors: MOSES PAULSON
Journal: JAMA (1927)

Although Manson-Bahr 1 has advocated the use of the sigmoidoscope in the detection of low sigmoid and upper rectal amebic ulcers, it is not apparent from the available literature that sigmoidoscopy has been used as a routine diagnostic measure to determine the presence of the intestinal protozoa in general. It is our purpose in this report to compare the incidence of protozoan parasites of the human intestine from specimens of feces obtained by the use of the sigmoidoscope with the usual defecated specimens submitted for examination. Similar procedure is being employed in the estimation and study of the bacterial flora of the large bowel.  This work was undertaken at the suggestion of Dr. Thomas R. Brown, associate professor of clinical medicine and chief of the gastro-intestinal clinic.  MATERIALS AND METHODS  The types of persons examined were extremely varied. A group of nationalities was represented which appeared at the clinic for
Failure to detect production of IL-10 by activated human neutrophils
Authors: Martin S Davey, Nicola Tamassia, Marzia Rossato, Flavia Bazzoni, Federica Calzetti, Kirsten Bruderek, Marina Sironi, Lisa Zimmer, Barbara Bottazzi, Alberto Mantovani, Sven Brandau, Bernhard Moser, Matthias Eberl, Marco A Cassatella
Journal: Nature Immunology (2011)
Determinants of the Use of Coronary Angiography and Revascularization after Thrombolysis for Acute Myocardial Infarction
Authors: Louise Pilote, Dave P. Miller, Robert M. Califf, J. Sunil Rao, W. Douglas Weaver, Eric J. Topol
Journal: New England Journal of Medicine (1996)

Clinical trials and practice guidelines have identified clinical criteria for the use of coronary angiography and revascularization procedures after thrombolysis for acute myocardial infarction. The effect of these criteria on clinical practice has not been extensively evaluated.
CONFLUENT AND RETICULATE PAPILLOMATOSIS (GOUGEROT-CARTEAUD) AND PITYROSPORUM ORBICULARE
Authors: S. O. B. ROBERTS, J. M. LACHAPELLE
Journal: British Journal of Dermatology (1969)

SUMMARY.— A patient whose lesions satisfied the clinical and histological criteria for the diagnosis of confluent and reticulate papillomatosis (C.R.P.) is described. Many of the lesions showed yellow fluorescence and were heavily colonized by Pityrosporum orbiculare but no evidence was found of filament formation as in Malassezia furfur. Treatment with 10% sodium thiosulphate and with selenium sulphide resulted in virtual eradication of P. orbiculare and complete clearance of the eruption. The possibility is discussed that C.R.P. may represent a peculiar host reaction to heavy colonization by P. orbiculare.
Influence of Abnormal Glucose Metabolism on Coronary Microvascular Function After a Recent Myocardial Infarction
Authors: Brian B. Løgstrup, Dan E. Høfsten, Thomas B. Christophersen, Jacob E. Møller, Hans E. Bøtker, Patricia A. Pellikka, Kenneth Egstrup
Journal: JACC. Cardiovascular imaging (2009)
"One stop" approach may be effective in preventing cervical cancer in Thailand
Authors: S. Mayor
Journal: BMJ (2003)

Treating women for potentially precancerous cervical lesions the same day they are detected could offer a practical approach to preventing cervical cancer in some developing countries, a study in Thailand has shown.

A group of 12 specially trained nurses offered women in four districts in Roi Et province—a mainly rural area—screening for cervical cancer using visual inspection of the cervix with acetic acid wash. Those who tested positive (showing raised and thickened white plaques) were offered cryotherapy during the same visit, after counselling about the benefits, potential risks, and probable side effects.

Results showed that 13% of the 5999 women who were screened during the seven month study tested positive. Nearly all (99%) of the women who were considered eligible accepted immediate treatment with cryotherapy. Eligibility criteria for treatment included the abnormalities …
PARTURITION FOLLOWED BY INVERSION OF THE UTERUS
Authors: W. H. Borham
Journal: BMJ (1855)

INSOiUGWAL OOKIUNCATIONS.208 oti or to the me; and could be returned without diffliclty into the cavity of the abdomen.The right lung was miuch smaller than usual.The stomach contained food he had recently taken; the internal membrane of the left ex- tremity was highly inflamed, probably from the operation of the emetic, and appeared to be the immediate cause of death.A case of fatal hernia of some of the abdominal viscera, strangulated in the cavity of the thorax, is recorded by Dr. Clarke, in the Transactions of the Society in London for Medicd and Chirurgici Improvement.The whole of the small and part of the great intestines had passed through an aperture in the diaphragm into the cavity of the chest.This aperture, which probably had existed from birth, was on the left side, about three inches from the ribs, more forwards than the natural opening for the oasophagus.A portion of the epiploon was carried up with the colon, and also a part of the outer edge of the left lobe of the liver.