tbuckley/cabot-search huggingface dataset:
Abstract 1638: Aspirin acetylates multiple cellular proteins in HCT-116 cells: Identification of novel targets
Authors: Jayarama B. Gunaje, Srinivasan Marimuthu, Raghavender S.V. Chivukula, Majid Moridani, Fred K. Hagen, Lloyd F. Alfonso
Journal: Cancer Research (2012)

Abstract Aspirin, a non-steroidal anti-inflammatory drug has been consistently associated with a reduced risk of colon cancer; however, the molecular mechanisms are not completely understood. In the present study, we determined the ability of aspirin to acetylate, and post-transnationally modify cellular proteins in HCT-116 human cancer cells to understand the potential mechanisms by which it may exert anti-cancer effects. Using anti-acetyl lysine antibodies, here we demonstrate that aspirin causes the acetylation of multiple proteins whose molecular weight ranged from 20 to 200 kDa. The identity of these proteins was determined, using immune-affinity purification, mass spectrometry and immunoblotting. A total of 33 cellular proteins were potential targets of aspirin-mediated acetylation, while 16 were identified as common to both the control and aspirin-treated samples. These include enzymes of glycolytic pathway, cytoskeletal proteins, histones, ribosomal and mitochondrial proteins. The glycolytic enzymes which were identified include aldolase, glyceraldehyde 3 phosphate dehydrogenase, enolase, pyruvate kinase M2, and lactate dehydrogenase A and B chains. Immunoblotting experiments showed that aspirin also acetylated glucose 6-phosphate dehydrogenase and transketolase, both enzymes of pentose phosphate pathway involved in ribonucleotide biosynthesis. In vitro assays of these enzymes revealed that aspirin did not affect pyruvate kinase and lactate dehydrogenase activity; however, it decreased glucose 6-phosphate dehydrogenase activity. Selective inhibition of glucose 6-phosphate dehydrogenase and other key proteins through acetylation may represent important mechanisms by which aspirin may exert its anti-cancer effects. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1638. doi:1538-7445.AM2012-1638
QUANTIFICATION OF ROTATIONAL THALLIUM-201 MYOCARDIAL TOMOGRAMS
Authors: Kan Van Train, Ernest Garcia, Jamshid Maddahi, Joseph Areeda, John Friedman, James Bietendorf, Alan Waxman, Daniel Berman
Journal: Clinical Nuclear Medicine (1983)

Van Train, Kan; Garcia, Ernest; Maddahi, Jamshid; Areeda, Joseph; Friedman, John; Bietendorf, James; Waxman, Alan; Berman, Daniel Author Information
The Second Sound-Mitral Opening Snap (A2-OS) Interval during Exercise in the Evaluation of Mitral Stenosis
Authors: ABNER J. DELMAN, GARET M. GORDON, EMANUEL STEIN, DORIS J. W. ESCHER
Journal: Circulation (1966)

Cardiac catheterization and phonocardiography data were obtained from patients with mitral stenosis at rest and during exercise. There was a linear relationship between the percentage decrease of the interval from closure of the aortic valve to the mitral valve opening snap (A2-OS) and the percentage increase [see figure in the PDF file] of the left atrial mean pressure from rest to exercise. The duration of the A2-OS interval was an effective indicator of the level of the left atrial mean pressure during exercise. The duration of the A2-OS interval during exercise allowed separation of patients with mild stenosis from those with moderate or severe stenosis but could not be used to distinguish moderate stenosis from severe stenosis.
Evidence for altered hepatic gluconeogenesis in patients with cirrhosis using in vivo 31-phosphorus magnetic resonance spectroscopy
Authors: K.K. Changani, R. Jalan, I.J. Cox, M. Ala-Korpela, K.K. Bhakoo, S.D. Taylor-Robinson, J.D. Bell
Journal: Gut (2001)

<h3>BACKGROUND AND AIMS</h3> Alterations in gluconeogenesis in the diseased liver can be assessed non-invasively using magnetic resonance spectroscopy by measuring changes in phosphomonoester resonance which contains information regarding several metabolites, including the phosphorylated intermediates of the gluconeogenic pathway. <h3>METHODS</h3> <sup>31</sup>P magnetic resonance spectroscopy was used to determine changes in phosphomonoesters following bolus infusions of 2.8 mmol/kgl-alanine in five patients with functionally compensated cirrhosis and in five patients with functionally decompensated cirrhosis. <h3>RESULTS</h3> Compared with six healthy volunteers, baseline phosphomonoester values were elevated by 35% (p&lt;0.05) in the compensated cirrhosis group and by 57% (p&lt;0.01) in the decompensated cirrhosis group. Following alanine infusion, phosphomonoesters in healthy volunteers increased by 46% from baseline values (p&lt;0.01), in patients with compensated cirrhosis by 27% (p&lt;0.02) but those with decompensated cirrhosis showed no increase from baseline. There was a reduction in the percentage of inorganic phosphate signal in all subjects. <h3>CONCLUSIONS</h3> By analysing changes in phosphomonoester and inorganic phosphate resonances it is possible to discern clear metabolic differences between healthy volunteers and patients with cirrhosis of varying severity using magnetic resonance spectroscopy. Those patients with functionally decompensated cirrhosis have higher percentage baseline phosphomonoester values but the absence of phosphomonoester elevation following l-alanine infusion suggests that they are unable to mount a significant metabolic response with a progluconeogenic stimulus.
Brand Logo Recognition by Children Aged 3 to 6 Years
Authors: Paul M. Fischer
Journal: JAMA (1991)

<h3>Objective.</h3> —Little is known about the influence of advertising on very young children. We, therefore, measured product logo recognition by subjects aged 3 to 6 years. <h3>Design.</h3> —Children were instructed to match logos with one of 12 products pictured on a game board. Twenty-two logos were tested, including those representing children's products, adult products, and those for two popular cigarette brands (Camel and Marlboro). <h3>Setting.</h3> —Preschools in Augusta and Atlanta, Ga. <h3>Participants.</h3> —A convenience sample of 229 children attending preschool. <h3>Results.</h3> —The children demonstrated high rates of logo recognition. When analyzed by product category, the level of recognition of cigarette logos was intermediate between children's and adult products. The recognition rates of The Disney Channel logo and Old Joe (the cartoon character promoting Camel cigarettes) were highest in their respective product categories. Recognition rates increased with age. Approximately 30% of 3-year-old children correctly matched Old Joe with a picture of a cigarette compared with 91.3% of 6-year-old children. <h3>Conclusion.</h3> —Very young children see, understand, and remember advertising. Given the serious health consequences of smoking, the exposure of children to environmental tobacco advertising may represent an important health risk and should be studied further. (<i>JAMA</i>. 1991;266:3145-3148)
Bacterial translocation in cirrhotic rats. Its role in the development of spontaneous bacterial peritonitis.
Authors: J M Llovet, R Bartoli, R Planas, E Cabre, M Jimenez, A Urban, I Ojanguren, J Arnal, M A Gassull
Journal: Gut (1994)

Bacterial translocation occurs in ascitic cirrhotic rats, but its association with ascites infection is unknown. The aim of this study was to assess the relation between bacterial translocation and ascites infection in cirrhotic rats. Male Sprague-Dawley rats were induced to cirrhosis with intragastric CCl4. Ascitic fluid, portal and peripheral blood, mesenteric lymph nodes, liver and spleen samples were cultured before death in those cirrhotic rats with less (group A) or more (group B) than 250 polymorphonuclear neutrophils/mm3 in ascitic fluid, as well as in healthy control rats. Histological examination of jejunum, ileum, and caecum was also performed. Bacterial translocation occurred in 45% of ascitic rats (without differences between groups A and B), but in 0% controls (p = 0.01). Bacterial translocation was associated with positive ascitic fluid culture in 60% of the cases. In all of them the same bacterial species was isolated in both mesenteric lymph node and ascitic fluid. Submucosal caecal oedema (100%), ileal lymphangiectasia (41%), and caecal inflammatory infiltrate (41%) occurred in ascitic rats, the last being associated with ascitic fluid positive culture (p = 0.04). These results suggests that bacterial translocation occurs frequently in ascitic cirrhotic rats, and may play a permissive, but not unique, part in a number of ascites infections. Whether histological changes seen in cirrhotic ascitic rats favour bacterial translocation remains to be elucidated.
Guide tells editors how to root out plagiarism and fraud
Authors: Lynn Eaton
Journal: BMJ (2006)

Editors from some of the leading international biomedical and scientific journals—including the editor of the BMJ —have joined forces to produce a guide to rooting out poor and unethical practice in science publishing. 

The Committee on Publication Ethics has published a practical, step by step guide for journal editors, with 14 flow charts that give straightforward advice on what to do when facing certain publishing dilemmas. 

The flow charts include advice on what editors should …
Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8K108E mutation
Authors: Sandra Salem, David Langlais, François Lefebvre, Guillaume Bourque, Venetia Bigley, Muzz Haniffa, Jean-Laurent Casanova, David Burk, Albert Berghuis, Karina M. Butler, Timothy Ronan Leahy, Sophie Hambleton, Philippe Gros
Journal: Blood (2014)
Evolution of a Specialty
Authors: William J. Shaw
Journal: JAMA (1963)

IN THE BEGINNING God created heaven, earth, and the general practitioner. Without the ability to document this statement, it seems reasonable that Adam offered first aid to Abel following his altercation with Cain. In the absence of an obstetrician, Adam doubtless offered his services to Eve at their sons' births and may therefore be certified, there being no dissenting voices, as the original purveyor of medical care. Many nations have contributed to the heritage of medicine as we enjoy it today. Medical history is not available to follow its earliest progress. It is known that ancient Egypt tended toward grouping medical practitioners into specialties although Moses, who devised excellent health laws during the Exodus, was probably just a general practitioner. The Romans, taught largely by medical men from Greece and Alexandria, still have many residuals in Jerusalem of well-constructed aqueducts and other flood control devices. Hippocrates is still quoted and
α-METHYL-QUINOLINE AS A CONSTITUENT OF THE SECRETION OF THE ANAL GLANDS OF MEPHITIS MEPHITICA
Authors: Thomas B. Aldrich, Walter Jones
Journal: The Journal of Experimental Medicine (1897)

This is especiMly true when working with small quantities.t T. B. Aldrich, op.cir.B freed of the basic body is a clear, yellowish red, oily looking liquid, having a peculiar sweetish nauseating smell, and constituting about 37 per cent of the original secretion.For convenience we will call it B1.
LESIONS OF THE OPTIC NERVE AND RETINA IN PREGNANCY
Authors: HENRY P. WAGENER
Journal: JAMA (1934)

In the course of an apparently normal pregnancy, various ocular conditions may be encountered in which the influence of pregnancy must be taken into consideration. Hemorrhage into the vitreous, embolism or thrombosis of one of the branches of the central artery of the retina, acute chorioretinitis, retinal detachment, acute keratitis and iritis, paralysis of extra-ocular muscles and of accommodation, retrobulbar neuritis and homonymous hemianopia have been reported. In each instance the bearing of pregnancy on the severity of the disease or on its response to treatment must be evaluated. In the majority of cases, however, pregnancy is not directly connected with the causation of these lesions, and treatment can be carried out along the same lines and with as good results as if the patient were not pregnant. An interesting condition on which pregnancy does have a direct bearing but which has no very serious significance is hemeralopia, or night
Opening Skinner's Box: Great Psychological Experiments of the Twentieth Century
Authors: L. A. Neff
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FIVE YEARS' APPLICATION OF THE KAHN TEST
Authors: R. L. KAHN
Journal: JAMA (1927)

Since the Kahn test was first announced five years ago, it has been steadily gaining favor as a laboratory aid in the diagnosis of syphilis. In the beginning, the test was regarded as having only academic interest. Later, workers began to consider it a valuable check on the Wassermann test. Still later, especially with greater mastery of technic, many workers began to find the Kahn test the more dependable of the two methods. The result has been that during the past several years the Kahn test has replaced the Wassermann test in a number of laboratories. In this article, an attempt will be made to discuss briefly some of the practical features of the Kahn test, the relationship between the Wassermann and the Kahn test, and the interpretation of the latter. It is twenty years since the first attempt was made, by Michaelis, to evolve a precipitation method for detecting
A homozygous mutation in the ferrochelatase gene underlies erythropoietic protoporphyria associated with palmar keratoderma
Authors: M. Méndez, P. Poblete-Gutiérrez, M.-J. Morán-Jiménez, M.-E. Rodriguez, M.-C. Garrido-Astray, A. Fontanellas, J. Frank, R.E. de Salamanca
Journal: British Journal of Dermatology (2009)

Conflicts of interest:none declared. M.M. and P.P.‐G. contributed equally to this manuscript. J.F. and R.E.deS. share senior authorship. Erythropoietic protoporphyria (EPP) (OMIM 177000) is one of the nonacute, cutaneous porphyrias. The disease results from an inherited partial deficiency of ferrochelatase (FECH; EC 4.99.1.1), the eighth and ultimate enzyme in haem biosynthesis, that is located in the mitochondria and catalyses the insertion of iron into protoporphyrin IX to form haem.1, 2 Although EPP is a rare disease overall, it is the most common type of porphyria manifesting in childhood with an estimated prevalence of one in 130 000.3, 4 Clinically overt disease usually commences in infancy or early childhood and is characterized by moderate to severe cutaneous photosensitivity affecting body sites exposed to ultraviolet (UV) radiation. Following sun exposure, pain, burning, itching, erythema and swelling can develop within minutes to hours.1–4 Petechiae, purpura and vesicles may be seen, but are uncommon.5 Chronic UV exposure might lead to lichenification, subtle scarring and hyperpigmentation, particularly over the knuckles and on the nose.1, 3 These clinical signs in association with the age at onset are quite characteristic for EPP and the tentative diagnosis is confirmed by biochemical and enzymatic analyses.1–4 In 2–5% of the patients, the disease can be complicated by severe liver failure with progressive hepatic dysfunction.3
Daily emtricitabine plus tenofovir disoproxil fumarate reduced risk for HIV infection in men who have sex with men
Authors: Andre C. Kalil, Uriel S. Sandkovsky
Journal: Annals of Internal Medicine (2011)

ACP Journal Club19 April 2011Daily emtricitabine plus tenofovir disoproxil fumarate reduced risk for HIV infection in men who have sex with menAndre C. Kalil, MD, Uriel S. Sandkovsky, MDAndre C. Kalil, MDUniversity of Nebraska Medical Center, Omaha, Nebraska, USA (A.C.K., U.S.S.)Search for more papers by this author, Uriel S. Sandkovsky, MDUniversity of Nebraska Medical Center, Omaha, Nebraska, USA (A.C.K., U.S.S.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-8-201104190-02002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationGrant RM, Lama JR, Anderson PL, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010;363:2578-99. https://pubmed.ncbi.nlm.nih.gov/21091279Clinical Impact RatingsGIM/FP/GP: Infectious Disease: References1 Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010;329:1168-74. [PMID: 20643915] Google Scholar2 Centers for Disease Control and Prevention (CDC). Interim guidance: preexposure prophylaxis for the prevention of HIV infection in men who have sex with men. MMWR Morb Mortal Wkly Rep. 2011;60:65-8. [PMID: 21270743] Google Scholar Author, Article, and Disclosure InformationAuthors: Andre C. Kalil, MD; Uriel S. Sandkovsky, MDAffiliations: University of Nebraska Medical Center, Omaha, Nebraska, USA (A.C.K., U.S.S.)This article was published at Annals.org on 5 April 2011. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 April 2011Volume 154, Issue 8Page: JC4-2KeywordsDrugsHIV infectionsHypoglycemicsInfectious diseasesMale male sexual contactNauseaPopulation statisticsPreexposure prophylaxisTreatment guidelinesWeight loss ePublished: 19 April 2011 Issue Published: 19 April 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Impact of polymorphisms in the genes encoding xylosyltransferase I and a homologue in type 1 diabetic patients with and without nephropathy
Authors: Sylvia Schön, Christian Prante, Sandra Müller, Manuela Schöttler, Lise Tarnow, Joachim Kuhn, Knut Kleesiek, Christian Götting
Journal: Kidney International (2005)
Mortality by Hispanic Status in the United States
Authors: Paul D. Sorlie
Journal: JAMA (1993)

<h3>Objective.</h3> —To compare all-cause and cause-specific mortality rates between Hispanic and non-Hispanic groups and estimate the effect of family income, place of birth, and place of residence on these rates. <h3>Design.</h3> —Cohort study using national survey data matched to the National Death Index, with a mortality follow-up period of 9 years. <h3>Setting.</h3> —The noninstitutionalized population of the United States. <h3>Participants.</h3> —Approximately 700000 respondents (aged 25 years or older), including 40 000 Hispanics, to national surveys conducted by the US Bureau of the Census (Current Population Surveys). <h3>Outcome Measures.</h3> —All causes and underlying cause of death, coded from the death certificate, occurring between 1979 and 1987. <h3>Results.</h3> —Adjusting for age, Hispanics were shown to have lower mortality from all causes compared with non-Hispanics (standardized rate ratio [SRR], 0.74 for men, 0.82 for women), lower mortality from cancer (SRR, 0.69 for men, 0.61 for women), lower mortality from cardiovascular disease (SRR, 0.65 for men, 0.80 for women), higher mortality from diabetes (SRR, 1.86 for men, 2.38 for women), and higher mortality from homicide (SRR, 3.60 for men). After adjusting for differences in annual family income, the relative mortality ratios were even lower for Hispanics than non-Hispanics. <h3>Conclusion.</h3> —These data describe, in a large national cohort study, a lower mortality in Hispanics than in non-Hispanics. This mortality is particularly low after adjustment for differences in family income. (<i>JAMA</i>. 1993;270:2464-2468)
Within a Closed Space
Authors: John Willson
Journal: JAMA (1991)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SYMPTOMATIC AND ASYMPTOMATIC CHILDREN WITH VENTRICULAR PREEXCITATION: SAME RISK FOR SUDDEN DEATH
Authors: Corrado Di Mambro, Mario Salvatore Russo, Daniela Righi, Massimo Stefano Silvetti, Silvia Placidi, Rosalinda Palmieri, Lorenzo Santucci, Monica Prosperi, Fabrizio Gimigliano, Fabrizio Drago
Journal: Journal of the American College of Cardiology (2013)
CDC Estimates 300 000 US Cases of Lyme Disease Annually
Authors: Bridget M. Kuehn
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal