tbuckley/cabot-search huggingface dataset:
ICCE Consensus for Obscure Gastrointestinal Bleeding
Authors: M. Pennazio, G. Eisen, N. Goldfarb
Journal: Endoscopy (2005)

The annual incidence of gastrointestinal bleeding in the United States has been conservatively estimated at approximately 100 episodes per 100,000 persons, accounting for approximately 300,000 hospitalizations per year [1]. Obscure gastrointestinal bleeding represents about 5 % of those patients with gastrointestinal bleeding of any type. It is defined as bleeding of unknown origin that persists or recurs (i. e., recurrent or persistent iron-deficiency anemia, fecal occult blood test positivity, or visible bleeding) after a negative initial or primary endoscopy (upper and/or lower gastrointestinal endoscopy) [2]. The source of bleeding is frequently located in the small bowel and can result from a number of conditions, including vascular lesions, tumors, and inflammatory lesions.
Routine colonoscopies miss more than 10% of polyps
Authors: Scott Gottlieb
Journal: BMJ (2004)

A study of adults who did not have signs of colon disease found that traditional optical (flexible) colonoscopies missed more than a tenth of precancerous polyps that were identifiable with virtual colonoscopy, a new “virtual” procedure using computed tomography to form three dimensional images of the colon.

In the study, researchers led by Dr Perry Pickhardt of the University of Wisconsin Medical School, Madison, evaluated 1233 asymptomatic adults (mean age 57.8 years) who had virtual colonoscopy and optical colonoscopy on the …
The Impact of a Rotorcraft Aeromedical Emergency Care Service on Trauma Mortality
Authors: William G. Baxt
Journal: JAMA (1983)

The mortality of 150 consecutive trauma patients treated at the site of injury and transported to a trauma center by standard land prehospital care services was compared with that of 150 consecutive trauma patients treated at the site of injury and transported to the same trauma center by a rotorcraft aeromedical service staffed by a physician and nurse. A statistical analysis designed to predict mortality based on injury severity revealed that the mortality of the land group was statistically no different from that of a large index trauma patient population treated at a major trauma center. There was a 52% reduction in predicted mortality of the aeromedical group, which was highly significant.
Treatment for acute anterior cruciate ligament tear: five year outcome of randomised trial
Authors: R. B. Frobell, H. P. Roos, E. M. Roos, F. W. Roemer, J. Ranstam, L. S. Lohmander
Journal: BMJ (2013)

To compare, in young active adults with an acute anterior cruciate ligament (ACL) tear, the mid-term (five year) patient reported and radiographic outcomes between those treated with rehabilitation plus early ACL reconstruction and those treated with rehabilitation and optional delayed ACL reconstruction.Extended follow-up of prospective randomised controlled trial.Orthopaedic departments at two hospitals in Sweden.121 young, active adults (mean age 26 years) with acute ACL injury to a previously uninjured knee. One patient was lost to five year follow-up.All patients received similar structured rehabilitation. In addition to rehabilitation, 62 patients were assigned to early ACL reconstruction and 59 were assigned to the option of having a delayed ACL reconstruction if needed.The main outcome was the change from baseline to five years in the mean value of four of the five subscales of the knee injury and osteoarthritis outcome score (KOOS(4)). Other outcomes included the absolute KOOS(4) score, all five KOOS subscale scores, SF-36, Tegner activity scale, meniscal surgery, and radiographic osteoarthritis at five years.Thirty (51%) patients assigned to optional delayed ACL reconstruction had delayed ACL reconstruction (seven between two and five years). The mean change in KOOS(4) score from baseline to five years was 42.9 points for those assigned to rehabilitation plus early ACL reconstruction and 44.9 for those assigned to rehabilitation plus optional delayed reconstruction (between group difference 2.0 points, 95% confidence interval -8.5 to 4.5; P=0.54 after adjustment for baseline score). At five years, no significant between group differences were seen in KOOS(4) (P=0.45), any of the KOOS subscales (P ≥ 0.12), SF-36 (P ≥ 0.34), Tegner activity scale (P=0.74), or incident radiographic osteoarthritis of the index knee (P=0.17). No between group differences were seen in the number of knees having meniscus surgery (P=0.48) or in a time to event analysis of the proportion of meniscuses operated on (P=0.77). The results were similar when analysed by treatment actually received.In this first high quality randomised controlled trial with minimal loss to follow-up, a strategy of rehabilitation plus early ACL reconstruction did not provide better results at five years than a strategy of initial rehabilitation with the option of having a later ACL reconstruction. Results did not differ between knees surgically reconstructed early or late and those treated with rehabilitation alone. These results should encourage clinicians and young active adult patients to consider rehabilitation as a primary treatment option after an acute ACL tear.Current Controlled Trials ISRCTN84752559.
Orthopaedic Management of Cerebral Palsy
Authors: Irwin M. Siegel
Journal: JAMA (1979)

"Orthopaedic surgery appears to have established a permanent and important place in the management of cerebral palsy." So writes Eugene E. Bleck, who, drawing from his understanding and experience, has written what may well prove the definitive review of this subject. The book's format follows the clinical classification of cerebral palsy, with chapters devoted to its three main forms—hemiplegia, diplegia, and total body involvement. A thorough outline of "Orthopaedic Assessment" (including methods for documenting findings such as photographic recordings and pedographs), a provocative presentation of "Neurobiology, Prognosis and Structural Changes," and a sensible outline of "Goals and Methods of Treatment," which stresses "management tempered by social consideration" ("The goal of treatment is a healthy functionally independent person, not a permanent patient"), round out the text. The anatomy, physiology, and biomechanics of all major spastic deformities are discussed. Clinical examination, indications for surgery, alternative techniques (eg, myoneural block and biofeedback), operative
Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1
Authors: Verneri Anttila, Hreinn Stefansson, Mikko Kallela, Unda Todt, Gisela M Terwindt, M Stella Calafato, Dale R Nyholt, Antigone S Dimas, Tobias Freilinger, Bertram Müller-Myhsok, Ville Artto, Michael Inouye, Kirsi Alakurtti, Mari A Kaunisto, Eija Hämäläinen, Boukje de Vries, Anine H Stam, Claudia M Weller, Axel Heinze, Katja Heinze-Kuhn, Ingrid Goebel, Guntram Borck, Hartmut Göbel, Stacy Steinberg, Christiane Wolf, Asgeir Björnsson, Gretar Gudmundsson, Malene Kirchmann, Anne Hauge, Thomas Werge, Jean Schoenen, Johan G Eriksson, Knut Hagen, Lars Stovner, H-Erich Wichmann, Thomas Meitinger, Michael Alexander, Susanne Moebus, Stefan Schreiber, Yurii S Aulchenko, Monique M B Breteler, Andre G Uitterlinden, Albert Hofman, Cornelia M van Duijn, Päivi Tikka-Kleemola, Salli Vepsäläinen, Susanne Lucae, Federica Tozzi, Pierandrea Muglia, Jeffrey Barrett, Jaakko Kaprio, Markus Färkkilä, Leena Peltonen, Kari Stefansson, John-Anker Zwart, Michel D Ferrari, Jes Olesen, Mark Daly, Maija Wessman, Arn M J M van den Maagdenberg, Martin Dichgans, Christian Kubisch, Emmanouil T Dermitzakis, Rune R Frants, Aarno Palotie
Journal: Nature Genetics (2010)
Accuracy of Small-Intestine Contrast Ultrasonography, Compared With Computed Tomography Enteroclysis, in Characterizing Lesions in Patients With Crohn's Disease
Authors: Emma Calabrese, Francesca Zorzi, Sara Onali, Elisa Stasi, Roberto Fiori, Simonetta Prencipe, Antonino Bella, Carmelina Petruzziello, Giovanna Condino, Elisabetta Lolli, Giovanni Simonetti, Livia Biancone, Francesco Pallone
Journal: Clinical Gastroenterology and Hepatology (2013)
Paget's disease of bone in 14 British towns.
Authors: D J Barker, P W Clough, P B Guyer, M J Gardner
Journal: BMJ (1977)

The radiological prevalence of Paget9s disease was studied in 14 towns. Routine radiographs showed that the disease was present in 5.4% of people aged 55 years and over. The disease was more prevalent in men than in women at all ages, and the prevalence increased with age. The three Lancashire towns studied (Preston, Bolton, and Blackburn) had higher rates than elsewhere. This probably reflects a real geographical variation in the prevalence of Paget9s disease in England and Wales.
TLR2 Activation By Supernatant From Bifidobacterium Breve Modulates Maturation And Survival Of Human DCs Via Differential Effects On PI3Kinase, p38 And ERK Pathways
Authors: C. Hoarau, L. Martin, F. Velge-roussel, C. Gontier, Y. Lebranchu
Journal: Journal of Allergy and Clinical Immunology (2007)
Physician Participation in Olympic Game Planning
Authors: Daniel F. Hanley
Journal: JAMA (1964)

<h3>To the Editor:—</h3> This letter is written in reply to the editorial, "Physician Participation in Olympic Game Planning" (<i>JAMA</i><b>189:</b>233 [July 20] 1964). The editorial is full of inaccuracies, misstatements of fact, and unfair innuendos. As one of the physicians who was present with the Olympic team in Rome, I would like to correct the statement, "They were not involved in comprehensive planning and did not have the time at the site of competition to overcome the resulting difficulties." We were involved in the planning for the trip to Rome and, since 1962, have been involved in the planning for the trip to Tokyo. And, as far as "time at the site of competition" goes, we lived at the Olympic Village and a physician was on duty at all times, 24 hours a day. I saw no medical "difficulties" that were not overcome. The statement that there were "several
Near patient testing. Needs quality control.
Authors: I Young
Journal: BMJ (1993)

matory drugs may exert tumoricidal effects in the colon,4 thus accounting for the reduced risk of cancer of the colon with regular use of these drugs.Large scale therapeutic trials of non-steroidal antiinflammatory drugs in established cancers of the colon and chemopreventive trials in high risk patients would therefore be appropriate since the risk of potential side effects in such cohorts would be justified.Initial reports of such studies are encouraging.5
Let's think operationally
Authors: L. N. Smith
Journal: BMJ (2011)

Reports of appalling nursing care cause shame, bewilderment, and anger. Failure to care is an act of betrayal. Delamothe’s editor’s choice prompted much discussion among nurses completing their MScHC at the University of Glasgow.1 These nurses hold nursing to be a caring profession with clinical expertise, good communication, and compassion as the cornerstones of practice.

Nurses do …
Typhoid Secondary Infection.
Authors: W. S. McClanahan
Journal: JAMA (1896)

Woodhull, Ill., July 20, 1896. <h3>To the Editor:</h3> —It was with considerable pleasure and satisfaction that I read the decision of the court of appeals of Colorado, Jones vs. Vroom, reported in ourJournal, July 18, page 169. The reason it is interesting to me is that I have a case pending, to come in the October term of court, where I have been sued for the loss of an eye from typhoid fever. My case was one of four cases that got their contagion in the same locality. Three different physicians treated the four cases. They were all extremely bad cases and they all died except this one case which lived, but has lost the sight of one eye from sloughing of the cornea. The case you reported appears to be very similar to mine, except the fact that they promised to provide a specialist and did not, while
The Diagnostic Value of the Forced Expiratory Time
Authors: David Tanaka
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Schapira et al<sup>1</sup>executed an excellent study of the FET in the diagnosis of obstructive airways disease. However, we are concerned about the reproducibility of the maneuver. We studied four internists examining 92 patients, yielding 342 examinations.<sup>2</sup>As in the study of Schapira et al, we used blinded, board-certified internists, who measured the FET while listening to the trachea with a stethoscope. We also trained our clinicians prior to the study by examining model patients. Unlike the study of Schapira et al, our examiners measured the FET with ordinary wristwatches, rather than stopwatches, and recorded the time to the nearest half second. When we analyzed our data using the spirometric and FET criteria of Schapira et al, we found that 38% of patients had airway obstruction. The κ statistic for measuring interphysician agreement was 0.27. When we explored the reason for only "fair agreement" between
REVIEW OF BRITISH NATIONAL LYMPHOMA INVESTIGATION STUDIES OF HODGKIN'S DISEASE AND DEVELOPMENT OF PROGNOSTIC INDEX
Authors: J.L. Haybittle, M.J. Easterling, M.H. Bennett, B.Vaughan Hudson, F.G.J. Hayhoe, A.M. Jelliffe, G.Vaughan Hudson, K.A. Maclennan
Journal: The Lancet (1985)
Familial lupoid thrombocytopenia
Authors: Kazuyuki Shimizu, Itsuro Katsuta, Takashi Uchikawa
Journal: American Journal of Hematology (1993)

Abstract Familial lupoid thrombocytopenia affecting three subjects in three generations is reported. All subjects had antinuclear antibodies with or without antibodies to single‐stranded DNA, an increase in platelet‐associated IgG, and a family member with an autoimmune disease. These findings implicate a genetic contribution. All subjects shared a common HLA haplotype. © 1993 Wiley‐Liss, Inc.
Grappenanalyse im klinischen Feld
Authors: M. Pohlen
Journal: Psychotherapy and Psychosomatics (1972)

This report contains a description of the theoretical background of the scientific procedure in psychotherapeutic research. It represents a new model of cooperation which should take into account the field-specific conditions of the clinical situation; i. e. according to the working hypothesis, clinical work is to be regarded as a process of the entire group encompassing staff- and patient-group and correspondingly the therapeutic work was structured in a bifocal system. A second working hypothesis supposed that the group process reflects family organization. Psychotic and neurotic developments seem to follow the same socío-and psycho-dynamic mechanisms in this reciprocal exchange system of the family. For this reason, this group-model was designed as an integrated scheme of treatment for psychotics and neurotics. The results of the therapeutic work are described for the hysterics in the findings of the GPI, the questionnaire of mood-characteristics and the 16-Personality-Factor-Questionnaire of Cattell. The results of the other types of illness, not discussed here, likewise showed findings expected for these illness- resp. behaviour-representatives in the sense of the hypothesis.
Distribution of the 10,000 molecular weight calcium binding protein along the small and large intestine of man.
Authors: M Staun
Journal: Gut (1987)

The distribution of the 10,000 molecular weight calcium binding protein along the human small and large intestine was studied using an enzyme linked immunoadsorbent assay. Small intestinal mucosal samples were obtained from the duodenal bulb, the second and third part of the duodenum and at about 50 cm intervals from jejunum and ileum of five whole small intestines of necro-kidney donors. Mucosal samples of caecum, colon ascendens, and transversum were also investigated. The amount of calcium binding protein per milligram of cytosolic protein increased throughout duodenum to reach the maximum in the proximal segment of jejunum and then declined steadily to nearly undetectable levels in ileum. In the colon no 10,000 molecular weight CaBP was detectable. The distribution of CaBP along the small and large intestine of man is thus parallel to the efficiency of the active calcium absorption of human intestine.
Care at the End of Life
Authors: Wendy L. Adams, Catherine Eberle
Journal: Annals of Internal Medicine (1997)

Letters1 October 1997Care at the End of LifeWendy L. Adams, MD, MPH and Catherine Eberle, MDWendy L. Adams, MD, MPHUniversity of Nebraska Medical Center; Omaha, NE 68198-5620Search for more papers by this author and Catherine Eberle, MDUniversity of Nebraska Medical Center; Omaha, NE 68198-5620Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-7-199710010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The excellent review by Hanson and colleagues [1] reveals a striking omission in interventions designed to change care at the end of life. All the studies cited aimed to increase communication about the patient's preferences for care or to reduce the use of certain types of interventions. None apparently offered the patients or their caregivers meaningful and realistic alternatives to usual hospital care.Terminal illness often brings with it disability; pain; and the need for assistance with eating, bathing, dressing, and toileting. In our society, the options for meeting these needs are very limited. Hospice care is ...References1. Hanson LC, Tulsky JA, Danis M. Can clinical interventions change care at the end of life? Ann Intern Med. 1997; 126:381-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Nebraska Medical Center; Omaha, NE 68198-5620 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1997Volume 127, Issue 7Page: 574KeywordsDisabilitiesDyspneaEatingEmotionsEnd of life careHealth careNursing homesPain managementPalliative carePatients ePublished: 15 August 2000 Issue Published: 1 October 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Ethnicity variables in the incidence rates of leukemias in New Zealand populations: Implications for stem‐cell transplantation
Authors: Mary Clare Tracey, John M. Carter
Journal: American Journal of Hematology (2005)

Abstract New Zealand has a population of 4 million people comprising four main ethnic groups: Caucasian (72.9%), New Zealand Maori (14.7%), New Zealand Pacific Islands people (5.6%), and Asians (6.3%). We examined 10 years of data (1993–2002) from the New Zealand Cancer Registry to determine if there are ethnic differences in leukemia incidence in New Zealand, and we relate this to availability of stem‐cell transplantation. We found that New Zealand Asians have a generally lower incidence of all leukemias investigated. New Zealand Maori have an increased risk of acute myeloid leukemia (RR 1.5 in the age group 25–49 and RR 1.31 in the age group 50–74), relative to New Zealand Caucasians. New Zealand Pacific Islanders have an increased risk of chronic myeloid leukemia (RR 2.13 in the age group 25–49 and RR 1.52 in the age group 50–74). Stem‐cell transplantation is a standard curative treatment for ages 25–49, and current opinion is extending the acceptable age up to age 60, in certain cases. We conclude that, among New Zealand Maori and New Zealand Pacific Islanders, there is an increased risk of acute myeloid leukemia and chronic myeloid leukemia in age groups suitable for stem‐cell transplantation. However, both of these ethnic groups have previously been shown to have a reduced chance of finding a 6/6‐matched unrelated donor on international registries. This leads to disproportionate provision of transplantation health care among the ethnic groups in New Zealand. Am. J. Hematol. 79:114–118, 2005. © 2005 Wiley‐Liss, Inc.
Medicare Coverage of Angiotensin-Converting Enzyme Inhibitors
Authors: Vinod N. Velakaturi
Journal: Annals of Internal Medicine (2005)

Letters20 December 2005Medicare Coverage of Angiotensin-Converting Enzyme InhibitorsVinod N. Velakaturi, MDVinod N. Velakaturi, MDFrom Jackson County Medical Group, Lees Summit, MO 64064.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-12-200512200-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I must disagree with the assertion by Rosen and colleagues (1) that the average cost of angiotensin-converting enzyme inhibitors is $233 per year or $19.42 per month. I have numerous patients who go to Costco or SAM's Club wholesale outlets because they can purchase generic lisinopril at far lower prices. These establishments do not require membership to buy prescription medications because they have legal pharmacies within the store.My patients are able to purchase lisinopril (10-mg tablets) for approximately $18 per 100 tablets at a cost of $72 annually. The 20-mg dose, also fairly common for management ...Reference1. Rosen AB, Hamel MB, Weinstein MC, Cutler DM, Fendrick AM, Vijan S. Cost-effectiveness of full Medicare coverage of angiotensin-converting enzyme inhibitors for beneficiaries with diabetes. Ann Intern Med. 2005;143:89-99. [PMID: 16027450] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Vinod N. Velakaturi, MDAffiliations: From Jackson County Medical Group, Lees Summit, MO 64064.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCost-Effectiveness of Full Medicare Coverage of Angiotensin-Converting Enzyme Inhibitors for Beneficiaries with Diabetes Allison B. Rosen , Mary Beth Hamel , Milton C. Weinstein , David M. Cutler , A. Mark Fendrick , and Sandeep Vijan Medicare Coverage of Angiotensin-Converting Enzyme Inhibitors Allison B. Rosen , A. Mark Fendrick , and Sandeep Vijan Metrics 20 December 2005Volume 143, Issue 12Page: 918KeywordsAngiotensin converting enzyme inhibitorConflicts of interestHypertensionMedicare ePublished: 20 December 2005 Issue Published: 20 December 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Arguments Over Behavior and Heart Disease Continue
Authors: Alfred Coodley
Journal: JAMA (1975)

<h3>To the Editor.—</h3> A superb example of reductio ad absurdum is embodied in the MEDICAL NEWS article, "Arguments Over Behavior and Heart Disease Continue" (232:697, 1975). For leaders in cardiology and preventive medicine to engage in an argument as to whether emotional factors or hypertension or cigarette smoking or diet or hypercholesterolemia represents the crucial etiologic factor in coronary disease puts all three of those physicians into the type A behavior bracket. So they all should stop smoking, watch their blood pressure, exercise, and cut down on high cholesterol foods. Oh yes, maybe the hearts of all three physicians would profit by their seeing a psychiatrist!