tbuckley/cabot-search huggingface dataset:
Abstract 3046: Phosphodiesterase 4D (PDE4D) as a new drug target for prostate cancer
Authors: Kimberly D.P Hammer, Maribella Domenech, David Beebe, Paul C. Marker
Journal: Cancer Research (2011)

Abstract Our laboratory used an insertional somatic mutagenesis screen in mice to identify novel genes that may drive prostate cancer initiation and progression. Using this screen, we have identified candidate prostate cancer genes including the candidate oncogene phosphodiesterase 4D (PDE4D). Investigation of PDE4D showed that it was over-expressed in human prostate cancer cell lines and in human prostate cancers. Stable knockdown of PDE4D by shRNA reduced the growth and migration of prostate cancer cells in vitro and in vivo. PDE4D has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Several small molecule PDE4D selective inhibitors have been developed and tested in clinical trials for COPD. Although these studies showed that the inhibitors had modest efficacy as a therapy for COPD, they confirmed that the inhibitors were safe for use in humans at doses that inhibited PDE4D in vivo. Based on our previous studies with PDE4D, we postulated that PDE4D small molecule inhibitors would be candidate anti-prostate cancer drugs. Daily oral administration of PDE4D inhibitors, NVP-ABE171 or cilomilast, for 6 weeks significantly reduced the growth of LNCaP-C4 prostate cancer xenografts in immune-compromised mice. Under in vitro conditions in which prostate cancer cell growth was inhibited by either NVP-ABE171 or cilomilast, we also observed changes in the activation of potential downstream molecular targets of PDE4D inhibition. Affected pathways included the sonic hedgehog and mitogen-activated protein kinase pathways. We also tested the potential role of the PDE4D pathway in prostate cancer stromal-epithelial interactions by modeling these interactions using novel microchannel co-culture devices. In this context, PDE4D inhibitors reduced the activation of Shh pathway target genes in mesenchymal cells and reduced the proliferation of epithelial cancer cell lines, supporting the potential importance of the PDE4D pathway for prostate cancer stromal-epithelial interactions. We are continuing in vitro and in vivo studies with these candidate drugs to further support the use of NVP-ABE171 and cilomilast as anti-prostate cancer drugs and to understand their mechanism of action. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3046. doi:10.1158/1538-7445.AM2011-3046
FRACTURE OF THE MIDTHIGH
Authors: Barclay W. Moffat
Journal: JAMA (1925)

The case here reported is one of fractured midthigh, in which it was necessary to cut down the period of hospitalization. The problem, therefore, was to find a suitable apparatus to maintain correction during the transportation of the patient to his home, a distance of 20 miles, and thereafter. C. L., aged 56, was admitted to the Monmouth Memorial Hospital, Long Branch, July 5, 1924, as an emergency case, following an automobile accident. Examination showed dislocation of the right elbow and fracture of the midshaft of the right femur. The elbow was reduced on admission, and the case referred for treatment of the fractured femur. A Balkan frame with traction and a Thomas splint was erected the following day to overcome the overriding of the fragments. July 16, the patient was placed on a Hawley table, and, under anesthesia, the fragments were placed end to end with the aid of
Health Promotion and Disease Prevention
Authors: Phil B. Fontanarosa
Journal: JAMA (1994)

Fifteen years ago,<i>Healthy People: The Surgeon General's Report on Health Promotion and Disease Prevention</i><sup>1</sup>established disease prevention as a primary strategy for improving the health of US citizens and emphasized health promotion as an essential component of the prevention imperative. In 1991, the publication of<i>Healthy People 2000: National Health Promotion and Disease Prevention Objectives</i><sup>2</sup>set forth priorities and specific objectives for health promotion, health protection, and preventive services and developed goals to enhance quality of life, decrease preventable death and disability, achieve universal access for preventive services, and reduce disparities in health status. Today, with health care providers, researchers, analysts, and policymakers attempting to design health care systems that provide accessible, affordable, and comprehensive health care, the concepts of health promotion and disease prevention have emerged at the forefront of the reform debate and are receiving greater attention than ever before. Despite health improvements achieved through
Coca Cola Statistics.
Authors: R. R. Kime
Journal: JAMA (1895)

63½Whitehall St., Atlanta, Ga., Sept. 21, 1895. <h3>To the Editor:</h3> —Desiring to find to what extent coca cola habitues are developed by the use of coca cola as a drink, I address this card to the medical profession, hoping that it will receive a ready response by any physician who has treated such cases. In replying, please state age of patient, sex, and amount drank daily. Hoping some good may result from such a collection of cases, I am, Yours respectfully,
Individual budgets for social care work for some people but not others
Authors: J. Wise
Journal: BMJ (2008)

Individual budgets for social care can give users more choice, flexibility, and control over their personal care compared with conventional support, a two year pilot scheme has shown. Users of mental health services and younger disabled people, in particular, reported benefits, but older people were less happy to manage their own support.

The programme was set up by the Department of Health to evaluate the costs, outcomes, and cost effectiveness of individual budgets as part of Putting People First ( BMJ 2007;335:1231, doi: 10.1136/bmj.39426.592176.DB).

Pilots were set up in 13 English local authorities, and an independent evaluation by five university research units was commissioned. The evaluation included a survey of 959 people interviewed about their experiences and outcomes six months after being offered an individual budget.

An individual budget brings together resources from different funding streams into a …
Implications of discrepancy in morphologic diagnosis of myelodysplastic syndrome between referral and tertiary care centers
Authors: Kiran Naqvi, Elias Jabbour, Carlos Bueso-Ramos, Sherry Pierce, Gautam Borthakur, Zeev Estrov, Farhad Ravandi, Stefan Faderl, Hagop Kantarjian, Guillermo Garcia-Manero
Journal: Blood (2011)
Inadequate Prescription-Drug Coverage for Medicare Enrollees — A Call to Action
Authors: S B Soumerai, D Ross-Degnan
Journal: New England Journal of Medicine (1999)

In summary, most low-income elderly and disabled persons lack coverage for important medications, resulting in avoidable deterioration of health among those with chronic illnesses and use of expensive institutional services. Rapidly escalating drug costs, more restrictive drug-coverage policies, and a dramatic increase in the population of elderly and disabled persons will exacerbate these problems. With the current budget surplus, as well as bipartisan concern about health care needs and public concern about drug costs and coverage, it is time to act responsibly and aggressively. We recommend a national replication of the best features of state pharmacy-assistance programs in a federal-state insurance program for low-income Medicare enrollees, either alone or in combination with expanded Medicare coverage. Such a program will reduce the current inequitable situation in which the most vulnerable patients have the least access to medications, with serious medical and economic consequences.
The kindness of strangers
Authors: E. Palmer
Journal: BMJ (2008)

My father died 30 years ago, at the age of 56. His GP had prescribed him dosulepin for a number of months, muttering something about “male menopause.” After a chest x ray showed something looking like a mountain snowstorm, he was belatedly admitted to a hospital many miles and many hours away from his home in the Cumbrian mountains. The snowstorm was disseminated adenocarcinoma from an unknown primary. It had also drifted into his liver.

I was in the first weeks of a first preregistration house officer post on the professorial surgical unit at a well known teaching hospital. The doctor who bleeped me was possibly a year further on in his career. “What do you think he’ll want us to do?” he asked me after telling me the biopsy results. “Do you think we should tell him?”

As a third year medical student I had been inspired by the simple humanity and kindness of the professor of surgery I was now working for. The world literature on what would 10 years later become the specialty of palliative medicine was on the bookshelf in my bedroom in the doctors’ residence. I had a handful of paperback books by early pioneers such as John Hinton and Richard Lamerton, alongside papers on early symptom control by Cecily Saunders and Mary Baines from St Christopher’s Hospice in London. I had no …
Sustainable Growth Rate
Authors: Mike Mitka
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analysis of Outcomes for Intravitreal Bevacizumab in the Treatment of Choroidal Neovascularization Secondary to Ocular Histoplasmosis
Authors: Douglas A. Cionni, Shawn A. Lewis, Michael R. Petersen, Robert E. Foster, Christopher D. Riemann, Robert A. Sisk, Robert K. Hutchins, Daniel M. Miller
Journal: Ophthalmology (2011)
Throat Culture Processing In the Office
Authors: Allen M. Mondzac
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Dr. Tubbs' letter reinforces the point I was attempting to make: The average practicing physician without trained technical help and with a minimum of bacteriologic training himself cannot utilize his office to culture beta hemolytic streptococci with any degree of reliability. It is obvious that Dr. Tubbs has a large laboratory with expert technical assistance and sophisticated equipment, and because of this he is probably processing throat cultures with reasonable accuracy. But his office situation is far from typical. My study showed that without such an office-laboratory as Dr. Tubbs has, throat culture results are inaccurate, and reliance upon such results can lead to mistreatment of streptococcal pharyngeal infections. The conditions imposed in the study were not intended to produce failure nor were they "viciously destructive" as Dr. Tubbs states. They were the conditions under which throat cultures were processed by the randomly selected volunteer group of
Vertebral hyperostosis and diabetes mellitus: a case-control study.
Authors: A Daragon, O Mejjad, P Czernichow, J P Louvel, O Vittecoq, A Durr, X Le Loet
Journal: Annals of the Rheumatic Diseases (1995)

To compare glucose metabolism in patients with vertebral hyperostosis (VH), with that in control patients.We studied 50 patients aged 60 years or more who had VH according to Resnick's criteria, and 50 control patients without VH, matched for sex, age, weight and height. Plasma glucose was evaluated before and 120 minutes after ingestion of 75 g glucose. World Health Organisation criteria for diabetes mellitus (DM) were used. Radiographs of the pelvis and thoracic and lumbar spine were performed and read blind by two physicians.Statistical analysis showed no difference between cases and control patients for prevalence of DM, and plasma glucose at 0 and 120 minutes.These data suggest that glucoregulation in patients with VH does not differ from that in matched controls.
Dissociation between regular and irregular in connectionist architectures: Two processes, but still no special linguistic rules
Authors: Marco Zorzi, Gabriella Vigliocco
Journal: Behavioral and Brain Sciences (1999)

Dual-mechanism models of language maintain a distinction between a lexicon and a computational system of linguistic rules. In his target article, Clahsen provides support for such a distinction, presenting evidence from German inflections. He argues for a structured lexicon, going beyond the strict lexicon versus rules dichotomy. We agree with the author in assuming a dual mechanism; however, we argue that a next step must be taken, going beyond the notion of the computational system as specific rules applying to a linguistic domain. By assuming a richer lexicon, the computational system can be conceived as a more general binding process that applies to different linguistic levels: syntax, morphology, reading, and spelling.
Influence of diabetes mellitus on intravenous thrombolysis effectiveness in patients with ST elevation myocardial infarction
Authors: Michael N. Zairis, Olga Papadaki, Stamatis Makrygiannis, Olga Ampartzidou, Pelagia Batika, Athanasios J. Manolis, Demetrios Beldekos, Christina Festeridou, Neophytos kassinos, Stelios Handanis, Apostolos Papantonakos, Stefanos Fouussas
Journal: Journal of the American College of Cardiology (2003)
Website of the week: Doctors' wellbeing
Authors: I. Haivas
Journal: BMJ (2003)

In a demanding profession like medicine, work related stress is neither something to be ashamed of nor a sign of incompetence. It just requires the right approach. A special issue this week of BMJ Careers focuses on wellbeing, offering advice on stress management (p s107), as well as guidance for ill doctors (p s103), and tips for maintaining wellbeing (p s109).
Socioeconomic Status and Coronary Heart Disease Risk Prediction
Authors: Kevin Fiscella, Daniel J Tancredi
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PWE-147 Nurse Led Day Case Paracentesis
Authors: L Dwyer, L Tobin
Journal: Gut (2014)

<h3>Introduction</h3> Refractory ascites is a debilitating condition. Prior to the implementation of nurse led day case paracentesis all patients were admitted into the hospital for an inpatient stay of between 3 and 5 days. An audit of inpatient paracentesis was carried out to assess the quality and efficiency of inpatient paracentesis. From this the service was developed to improve the overall quality of the patient experience and reduce inpatient admissions for paracentesis. Disease aetiology includes alcoholic liver disease, viral disease, autoimmune disease and advanced malignancy. <h3>Methods</h3> The hepatologist CNS was trained by the consultant hepatologist to perform paracentesis. All patients requiring paracentesis are referred directly to the CNS from GP’s, out patient clinics and the accident and emergency department. Patients are assessed in a pre procedure clinic by the CNS. A clinical examination is performed, bloods are checked and if necessary corrected accordingly to facilitate day case paracentesis. To date, the CNS has performed over 200 day case paracentesis procedures and complication rates remain below the national average. <h3>Results</h3> Data collected from a patient feedback exercise was extremely positive in all aspects of the nurse led day case paracentesis service. An audit of the service demonstrated no difference in overall outcomes when the CNS performed the paracentesis in comparison to the medical registrar. There has been a significant reduction in hospital bed days required for paracentesis. <h3>Conclusion</h3> Nurse led day case paracentesis is a safe, effective and economic alternative to costly inpatient hospital admissions. It has proven to be both beneficial to the service user and the NHS trust. Patients benefit from a key worker who specialises in the management of refractory ascites who can provide management and out patient intervention to avoid the potential compliactions of large volume refractiory ascites and unnecessary hospital admissions. <h3>Disclosure of Interest</h3> None Declared.
Occurrence of autoantibodies to human leucocyte elastase in Wegener's granulomatosis and other inflammatory disorders.
Authors: J.W Tervaert, L Mulder, C Stegeman, J Elema, M Huitema, H The, C Kallenberg
Journal: Annals of the Rheumatic Diseases (1993)

Antineutrophil cytoplasmic antibodies (ANCAs) constitute a new class of autoantibodies that seem to recognise myeloid lysosomal enzymes. The occurrence of ANCAs with specificity for human leucocyte elastase (HLE) was assessed in serum samples that were routinely submitted for ANCA determination. During a study period of more than six years anti-HLE was found in only six out of 1102 serum samples that produced a perinuclear or an atypical cytoplasmic staining pattern on ethanol fixed granulocytes. These six serum samples were from four patients with a clinical diagnosis of Wegener's granulomatosis but without a definite histological diagnosis, one patient with systemic vasculitis, and one patient with Cogan's syndrome. To further evaluate the prevalence of anti-HLE we tested 315 serum samples from patients with different forms of vasculitis and related disorders. Anti-HLE was detected in two patients only. Thus autoantibodies to HLE are rarely found in serum samples from patients with vasculitic or related disorders.
Low-Grade, Latent Prostate Cancer Volume: Predictor of Clinical Cancer Incidence?
Authors: Alice S. Whittemore, Joseph B. Keller, Rebecca Betensky
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Low-Grade, Latent Prostate Cancer Volume: Predictor of Clinical Cancer Incidence? Get access Alice S. Whittemore, Alice S. Whittemore Search for other works by this author on: Oxford Academic PubMed Google Scholar Joseph B. Keller, Joseph B. Keller Search for other works by this author on: Oxford Academic PubMed Google Scholar Rebecca Betensky Rebecca Betensky Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 17, 4 September 1991, Pages 1231–1235, https://doi.org/10.1093/jnci/83.17.1231 Published: 04 September 1991 Article history Received: 03 January 1991 Revision received: 28 April 1991 Accepted: 05 June 1991 Published: 04 September 1991
Crizotinib in Anaplastic Large-Cell Lymphoma
Authors: Carlo Gambacorti-Passerini, Cristina Messa, Enrico M. Pogliani
Journal: New England Journal of Medicine (2011)

Crizotinib in Anaplastic Large-Cell LymphomaTo the Editor: Crizotinib, an inhibitor of the anaplastic lymphoma kinase (ALK) tyrosine kinase, is active in non-small-cell lung cancers that have ALK expression. 1 ALK is fused to several partner genes (mainly the gene encoding nucleophosmin) in the majority of anaplastic large-cell lymphomas (ALCLs).ALK tyrosine kinase activity represents the driver alteration in this disease. 2ALK-positive ALCLs are highly responsive to cytotoxic drugs.However, relapses occur and require salvage therapy.We treated two patients who had relapsed ALK-positive ALCL with crizotinib at a dose of 250 mg twice daily.No glucocorticoids or other drugs with antineoplastic activity were allowed.Patient 1, a 26-year-old woman, received seven cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP-15) and had a partial response at 1 month.She was subsequently treated with standard salvage combination chemotherapy regimens in an attempt to prepare for autologous bone marrow transplantation.However, relapse occurred within 2 to 3 weeks after each regimen.Pretreatment evaluation included fever (temperatures >38°C), cervical and inguinal adenopathy, and positive results on positron-emission tomographic (PET) and computed tomographic (CT) images of paraaortic and iliac nodes; bone marrow aspiration showed 3% of cells with ALK rearrangement.She had a score of 3 on the Eastern Cooperative Oncology Group (ECOG) performance scale (indicating confinement to bed or chair 50% or more of waking hours).After the initiation of crizotinib, Patient 1's fever disappeared within 48 hours; by day 7, all palpable adenopathy had resolved.PET and CT images and bone marrow aspiration performed at 28 days showed complete regression of previous
Book Review Radiology of the Small Bowel Edited by Michael Y.M. Chen, Ronald J. Zagoria, David J. Ott, and David W. Gelfand. 469 pp., illustrated. New York, Igaku-Shoin, 1992. $89.50. 0-89640-217-7
Authors: Debra Gervais, Sanjay Saini
Journal: New England Journal of Medicine (1993)
Phenylguanine Found in Urine after Benzene Exposure
Authors: K. H. Norpoth, G. Muller, C. Schell, E. Jorg
Journal: Environmental Health Perspectives (1996)

Comparative investigations with synthetic N7-phenylguanine were carried out to clarify whether this compound is eliminated via the urine of rats as a benzene-derived nucleic acid adduct. As sensitive methods for detecting trace amounts of the compound, gas chromatography-mass spectroscopy, high performance liquid chromatography, and two immunoassays (enzyme-linked immunosorbent assay and fluoroimmunoassay) with appropriate monoclonal antibodies were used. The results indicate the excretion of several benzene-related guanine adducts slightly different from N7-phenylguanine that may possibly be hydroxylated. These adducts differ also from (O6-, N2- and C8-phenylguanine, respectively.