tbuckley/cabot-search huggingface dataset:
Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish
Authors: Ayca Cinaroglu, Chuan Gao, Dru Imrie, Kirsten C. Sadler
Journal: Hepatology (2011)

Many etiologies of fatty liver disease (FLD) are associated with the hyperactivation of one of the three pathways composing the unfolded protein response (UPR), which is a harbinger of endoplasmic reticulum (ER) stress. The UPR is mediated by pathways initiated by PRKR-like endoplasmic reticulum kinase, inositol-requiring 1A/X box binding protein 1, and activating transcription factor 6 (ATF6), and each of these pathways has been implicated to have a protective or pathological role in FLD. We used zebrafish with FLD and hepatic ER stress to explore the relationship between Atf6 and steatosis. A mutation of the foie gras (foigr) gene caused FLD and hepatic ER stress. The prolonged treatment of wild-type larvae with tunicamycin (TN), which caused chronic ER stress, phenocopied foigr. In contrast, acute exposure to a high dose of TN robustly activated the UPR but was less effective at inducing steatosis. The sterol regulatory element binding protein transcription factors were not required for steatosis in any of these models. Instead, depleting larvae of active Atf6 either through a membrane-bound transcription factor peptidase site 1 mutation or an atf6 morpholino injection protected them against steatosis caused by chronic ER stress, but exacerbated steatosis caused by acute TN treatment.ER stress causes FLD. A loss of Atf6 prevents steatosis caused by chronic ER stress but can also potentiate steatosis caused by acute ER stress. This demonstrates that Atf6 can play both protective and pathological roles in FLD.
A CASE OF PROLAPSED CORD
Authors: Horace Eddy Robinson
Journal: JAMA (1913)

From the point of view of the general practitioner, prolapsed cord is a serious complication and one which is liable to be met at any time. The following case is therefore of sufficient importance and interest, I believe, to justify its report. The patient, Lena C., a primipara aged 20, was examined during the eighth month and found to be in normal condition. She went into labor at term about 9 p. m. Labor progressed favorably until 10:45 the following morning, when the membranes ruptured. The patient was immediately put to bed, and it was noted that the cord was in the vagina. The knee-chest position was immediately assumed, and an unsuccessful attempt at replacing the cord was made. Cord pulsation was 132 and fairly strong. The patient was instructed to remain in the knee-chest position. Morphin was given, and assistance sent for. Following a second injection of morphin the
Clinical Sports Medicine
Authors: William A. Grana
Journal: JAMA (1984)

The title of this book is deceptive, because it implies a book with general application to sports medicine in the clinical situation. Actually it is a selection of the proceedings of the annual meeting of the New England Chapter of the American College of Sports Medicine. It is edited by Robert Cantu, MD, the chief of the Neurosurgery Service and director of the Service of Sports Medicine at the Emerson Hospital in Concord, Mass.  The book consists of 17 papers that have been organized by the editor into six separate sections. The purposes of the meeting program and this selection of papers are not stated. The 27 authors have varied backgrounds and credentials in medicine, physical education, physical therapy, public health, human performance, and fitness. All of these papers are nicely referenced, except the first, and all seemed based on information relatively current at the time of the meeting. Some
4 clinical decision rules plus<scp>D</scp>-dimer testing each had high sensitivity and low specificity for excluding acute pulmonary embolism
Authors: Andrew Dunn
Journal: Annals of Internal Medicine (2011)

Source Citation Douma RA, Mos IC, Erkens PM, et al; Prometheus Study Group. Performance of 4 clinical decision rules in the diagnostic management of acute pulmonary embolism: a prospective cohort study. Ann Intern Med. 2011;154:709-18. 21646554
Throwing the baby out with the bathwater: Problems in modeling aggregated eye-movement data
Authors: Gary Feng
Journal: Behavioral and Brain Sciences (2003)

Parameters in E-Z Reader models are estimated on the basis of a simple data set consisting of 30 means. Because of heavy aggregation, the data have a severe problem of multicolinearity and are unable to adequately constrain parameter values. This could give the model more power than the empirical data warrant. Future models should exploit the richness of eye movement data and avoid excessive aggregation.
Spiny Follicular Hyperkeratotic Papules on the Face
Authors: Samer Ghosn, Miguel Abboud, Mazen Kurban, Ossama Abbas
Journal: JAMA Pediatrics (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Farmworker Exposure to Pesticides: Methodologic Issues for the Collection of Comparable Data
Authors: Thomas A. Arcury, Sara A. Quandt, Dana B. Barr, Jane A. Hoppin, Linda McCauley, Joseph G. Grzywacz, Mark G. Robson
Journal: Environmental Health Perspectives (2006)

The exposure of migrant and seasonal farmworkers and their families to agricultural and residential pesticides is a continuing public health concern. Pesticide exposure research has been spurred on by the development of sensitive and reliable laboratory techniques that allow the detection of minute amounts of pesticides or pesticide metabolites. The power of research on farmworker pesticide exposure has been limited because of variability in the collection of exposure data, the predictors of exposure considered, the laboratory procedures used in analyzing the exposure, and the measurement of exposure. The Farmworker Pesticide Exposure Comparable Data Conference assembled 25 scientists from diverse disciplinary and organizational backgrounds to develop methodologic consensus in four areas of farmworker pesticide exposure research: environmental exposure assessment, biomarkers, personal and occupational predictors of exposure, and health outcomes of exposure. In this introduction to this mini-monograph, first, we present the rationale for the conference and its organization. Second, we discuss some of the important challenges in conducting farmworker pesticide research, including the definition and size of the farmworker population, problems in communication and access, and the organization of agricultural work. Third, we summarize major findings from each of the conference's four foci-environmental exposure assessment, biomonitoring, predictors of exposure, and health outcomes of exposure-as well as important laboratory and statistical analysis issues that cross-cut the four foci.
Rheumatoid arthritis: A synovial disease?
Authors: K. Fujii, M. Tsuji, M. Tajima
Journal: Annals of the Rheumatic Diseases (1999)

HypothesisAlthough rheumatoid arthritis (RA) is believed to be primarily an inflammatory disease of synovium, there is a good possibility that the initiation of the rheumatoid process is triggered by the autoimmune reaction involving type II collagen in the articular cartilage as a consequence of an unknown aetiological agent.Synovitis and other extra-articular features may be induced secondary to the immune complex formation in the subchondral area.Extensive scientific data on the immune nature of RA have been accumulated. 1 According to this, RA is considered to be an autoimmune disease that is presently incurable.Although its aetiology remains unknown, most investigators believe that RA is primarily an inflammatory disease of synovial membrane of the joints.However, here we show evidence that RA primarily involves articular cartilage and subchondral bone, not the synovium; this new direction of research may allow for the development of a specific treatment for the disease.It is generally accepted that the initial events in the development of articular damage is the proliferation of synovial cells together with inflammation and vascular neoformation in the stroma of synovial tissue. 2 As the disease progresses, the proliferating synovial tissue extends over the articular cartilage and erodes from the joint surface down to the subchondral bone.Eventually, small and large joints of the patient are destroyed, deformed and ankylosed.Recently, we have focused on the following clinical facts that raise an important question: Is RA really a synovial disease?Firstly, although administration of non-steroidal antiinflammatory drugs, anti-rheumatic medicines and corticosteroids is recognised as a fundamental conservative treatment for RA, these cannot completely suppress the synovitis of aVected joints.4][5] Secondly, synovitis progression tends to gradually decrease when articular cartilage and bone are severely destroyed in the advanced stages. 6Thirdly, active synovitis remarkably diminish after excision of articular cartilage and subchondral bone during prosthetic joint replacement even
(26) Necrobiosis lipoidica presenting on the face and scalp
Authors: A. Navaratnam, G.A. Hodgson
Journal: British Journal of Dermatology (1973)

Journal Article (26) Necrobiosis lipoidica presenting on the face and scalp Get access A. Navaratnam, A. Navaratnam Department of Dermatology, University Hospital of Wales, Cardiff Search for other works by this author on: Oxford Academic Google Scholar G.A. Hodgson G.A. Hodgson Department of Dermatology, University Hospital of Wales, Cardiff Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 89, Issue s9, 1 July 1973, Pages 100–101, https://doi.org/10.1111/j.1365-2133.1973.tb03459.x Published: 01 July 1973
Castle: Right Man, Time, and Place
Authors: EDWARD HUTH
Journal: Annals of Internal Medicine (1978)

Editorial Note1 December 1978Castle: Right Man, Time, and PlaceEDWARD HUTH, M.D.EDWARD HUTH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-6-1003 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe main business of medical schools is to prepare their students to care for the ill. But if that care is to be effective, it must have a scientifically valid basis. Building that scientific base is the second, but not minor, business of medical schools. This must be understood by legislators and others who finance medical education. But they must not think that medical science is to be supported solely with the expectation that solutions for human ills will steadily flow from the laboratories each year. What does this have to do with William B. Castle, whose work on pernicious...References1. KASS L: William B. Castle and intrinsic factor. Ann Intern Med 89:983-991, 1978 LinkGoogle Scholar2. The American College of Physicians Convocation Program. [Annual Session, 17 April 1978.] Philadelphia, American College of Physicians, 1978, pp. 24-25 Google Scholar3. ALLEN G: Castle, William Ernest Dictionary of Scientific Biography, vol. 3. New York, Charles Scribner's Sons, 1974, pp. 120-124 Google Scholar4. DUNN L: William Ernest Castle. Biograph Mem Natl Acad Sci 38:31-80, 1965 Google Scholar5. See Reference 4, p. 62 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EDWARD HUTH, M.D.Affiliations: Annals of Internal Medicine Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1978Volume 89, Issue 6Page: 1003-1004KeywordsMedical educationMotivation ePublished: 1 December 2008 Issue Published: 1 December 1978 PDF downloadLoading ...
The effect of oral indomethacin on psoriasis treated with the Ingram regime
Authors: R.A. SHEEHAN-DARE, M.J.D. GOODFIELD, N.R. ROWELL
Journal: British Journal of Dermatology (1991)

Fifty patients with psoriasis undergoing a standard Ingram regime were entered into a double‐blind comparison of oral indomethacin and placebo. No significant differences were observed between the two groups in respect of disease activity or dithranol tolerance after 6 weeks.
Modulation of Circulating Cellular Adhesion Molecules in Postmenopausal Women With Coronary Artery Disease
Authors: Teresa Caulin-Glaser, William J Farrell, Steven E Pfau, Barry Zaret, Katherine Bunger, John F Setaro, Joseph J Brennan, Jeffrey R Bender, Michael W Cleman, Henry S Cabin, Michael S Remetz
Journal: Journal of the American College of Cardiology (1998)

The present study examined the association of estrogen (E2) and the inflammatory response of endothelium in coronary artery disease (CAD) by measuring circulating cellular adhesion molecules (cCAMs) in subjects with atherosclerosis.Atherosclerotic plaque demonstrates features similar to inflammation. Endothelial cell activation by inflammatory cytokines induces expression of cellular adhesion molecules (CAMs), thereby perhaps augmenting leukocyte adhesion and recruitment and subsequent development of atherosclerosis. The incidence of CAD is lower in women; this may be due to the cardioprotective effects of E2.Consecutive eligible subjects with CAD admitted for cardiac catheterization were studied. The groups evaluated were men, postmenopausal women receiving E2 replacement therapy (ERT), postmenopausal women not receiving ERT and premenopausal women. Control groups included men and women without CAD. Preprocedural blood samples were drawn from all groups. Measurements of cCAMs, E-selectin, vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 were performed by enzyme-linked immunoabsorbant assay. E2 levels were assessed by radioimmunoassay.We observed a statistically significant increase in all cCAMs in men with CAD and postmenopausal women with CAD not receiving ERT compared with postmenopausal women with CAD receiving ERT. Premenopausal women with CAD and postmenopausal women with CAD receiving ERT had a significant increase in VCAM-1 alone compared with the female control group.A possible mechanism by which E2 exerts one of its cardioprotective effects is by limiting the inflammatory response to injury by modulating the expression of CAMs from the endothelium.
Book Review Surrogate Motherhood and the Politics of Reproduction By Susan Markens. 272 pp. Berkeley, University of California Press, 2007. $60 (cloth); $24.95 (paper). 978-0-520-25203-5 (cloth); 978-0-520-25204-2 (paper).
Authors: Tommaso Falcone, Ruth M. Farrell
Journal: New England Journal of Medicine (2008)
Ecological studies are a poor means of testing aetiological hypotheses
Authors: S. Ebrahim, G. D. Smith
Journal: BMJ (1998)

EDITOR—The declines in cardiovascular diseases in Poland, “apparently without precedent in peacetime,”1 are similar to the declines seen in Britain over the same period.2 The table shows secular declines in mortality from cardiovascular diseases in Britain: between 1991 and 1994, death rates from both ischaemic heart disease and stroke fell dramatically, particularly among men at all ages and women aged over 55 years. In Britain these death rates are continuing to fall, in contrast to Poland. Furthermore, as mortality from ischaemic heart disease in Britain plateaued between 1980 and 1985 and then fell, the declines observed between 1985 and …
Decline in the Cumulative Incidence of Severe Diabetic Retinopathy in Patients With Type 1 Diabetes
Authors: Janne P. Kytö, Valma Harjutsalo, Carol Forsblom, Kustaa Hietala, Paula A. Summanen, Per-Henrik Groop
Journal: Diabetes Care (2011)

To determine if the cumulative incidence of severe retinopathy in patients with type 1 diabetes has changed.The study looked at 3,781 patients diagnosed with type 1 diabetes (1939-2005), median age at onset 13 (interquartile range [IQR] 9-21) years, and duration of diabetes 19 (IQR 13-27) years. The severe retinopathy was based on a history of laser treatment. Patients were divided into <1975, 1975-1979, 1980-1984, and ≥1985 cohorts according to the diagnosis of diabetes.The cumulative incidence of severe retinopathy has declined (P < 0.0001). After 20 years of duration, the cumulative incidence was 23% (95% CI 21-25) and 33 (30-35) in the earliest cohorts, 18 (15-21) in the next cohort, and 6 (4-9) in the recent cohort. After 30 years, the cumulative incidence was 52 and 48% in the earliest cohorts, while it was 62% after 40 years in the earliest cohort.The cumulative incidence of severe retinopathy has declined in patients with type 1 diabetes.
[611] KETOPROFEN PLUS PEG-IFN ALPHA-2a AND RIBAVIRIN AS A TRIPLE TREATMENT FOR GENOTYPE 1 (G1) CHRONIC HEPATITIS C (CHC): RESULTS OF A PHASE II RANDOMIZED CONTROLLED TRIAL
Authors: A. Gramenzi, M. Margotti, C. Balsano, S. Anticoli, C. Cursaro, E. Loggi, F. Focetola, S. Galli, G. Furlini, M. Bernard, P. Andreone
Journal: Journal of Hepatology (2007)
A NEW METHOD OF HANDLING SMALL BLADDER DIVERTICULA
Authors: Frank S. Schoonover
Journal: JAMA (1924)

Since Young first described the inversion method of handling small diverticula, it has been widely used by urologic surgeons. It has been customary in these cases, after the diverticulum has been inverted into the bladder, to cut the mucosal lining off and suture the bladder wall. I have found that it is sometimes difficult to pull these diverticula up with the ordinary hemostatic forceps but by progressive application of Allis forceps it has been possible to invert diverticula with a capacity of 15 c.c. After the diverticulum has been pulled up so that the mucosa is on a level with the bladder wall, I have made this addition to the usual technic: Instead of excising the mucosa, a mattress suture has been placed in such a way that the loop of the suture passes through the bladder wall on each side of the original orifice of the diverticulum and is
INCIDENCE AND RISK FACTORS FOR CONTRAST-INDUCED NEPHROPATHY IN PRIMARY PERCUTANEOUS CORONARY INTERVENTION: AN ANALYSIS FROM THE HARMONIZING OUTCOMES WITH REVASCULARIZATION AND STENTS IN ACUTE MYOCARDIAL INFARCTION TRIAL (HORIZONS-AMI)
Authors: Amar Narula, Giora Weisz, George Dangas, Bimmer Clausen, Adam Saltzman, Ran Kornowski, Bruce Brodie, Dariuz Dudek, Eugenia Nikolsky, Bernhard Witzenbichler, Giulio Guagliumi, Martin Fahy, Helen Parise, Gregg W. Stone, Roxana Mehran
Journal: Journal of the American College of Cardiology (2011)
Hazards of Some Pediatric Cribs
Authors: William S. Properzio
Journal: JAMA (1985)

To the Editor.—  The Food and Drug Administration recently mailed a Safety Alert Letter describing a serious problem with pediatric cribs to more than 7,300 hospitals in the United States.  The FDA's Center for Devices and Radiological Health received reports of two deaths of young children, aged 17 and 23 months, as a result of entrapment between an incompletely fastened security top and the side rails of a pediatric crib. The two cribs involved were the Tabbert or Tab Crib, Model C-374; and the Hill-Rom Crib, Model 249. Additional label names, such as Today Crib, Model C-374, may also be in use. Various manufacturers' or distributors' names are involved. These include Midmark, Inc (800) 643-6275; Hill-Rom Co (812) 934-7777; Whittaker Medical Manufacturing Company or Whittaker General Medical (800) 446-3008; Cambridge Scientific Industries (800) 638-9566; and Inter-Royal Corporation (212) 686-3500. The FDA has classified Midmark's and Hill-Rom's voluntary corrective actions of
Ambulatory Surgical Centers
Authors: Stephen V. Stephenson
Journal: JAMA (1985)

<h3>To the Editor.—</h3> Today everyone is interested in containing the high price of medical care. Many innovative approaches have been initiated by health care professionals to help reduce medical costs. One of these approaches has been the development of ambulatory surgical centers across the United States. It has been well documented that ambulatory surgical center charges can save as much as 30% to 50% on the cost when compared with charges incurred when surgery is performed on an outpatient basis in a hospital setting. A substantial portion of all these surgical procedures are performed on elderly patients (aged 65 years or older, or recipients of Medicare). If a cataract extraction is performed at an ambulatory surgical center, the federal government has dictated that a maximum reimbursement of $329 be made. This outpatient fee is all-inclusive. If this same procedure is performed on an outpatient basis at a hospital, the charges
Psychological and Behavioral Implications of Abnormal Mammograms
Authors: Caryn Lerman, Bruce Track, Barbara K. Rimer, Alice Boyce, Chris Jepson, Paul F. Engstrom
Journal: Annals of Internal Medicine (1991)

To evaluate women's psychological responses to abnormal mammograms and the effect on mammography adherence. To identify psychological responses and other factors that predict mammography adherence in women with normal or abnormal mammograms.Survey study with prospective analysis of factors associated with mammography adherence.Health Maintenance Organization of Pennsylvania and New Jersey (HMO PA/NJ).Study patients, members of HMO PA/NJ who were 50 years of age or older, and who had had mammography done 3 months earlier, included women with normal mammograms (n = 121), women with low-suspicion mammograms (n = 119), and women with high-suspicion mammograms (n = 68), but not women with breast cancer.Psychological responses 3 months after mammography and adherence to subsequent annual mammography were assessed.Women with high-suspicion mammograms had substantial mammography-related anxiety (47%) and worries about breast cancer (41%). Such worries affected the moods (26%) and daily functioning (17%) of these women, despite diagnostic evaluation excluding malignancy. For each variable, a consistent trend (P greater than 0.05) was seen with degree of mammogram abnormality. Sixty-eight percent of women with normal results, 78% of women with low-suspicion results, and 74% of women with high-suspicion results obtained their subsequent annual mammograms (P greater than 0.05). The number of previous mammograms (odds ratio, 3.2; 95% CI, 1.6 to 6.2) and the effect of the previous results on concerns about breast cancer (odds ratio, 0.5; CI, 0.2 to 1.0) were independent predictors of adherence in logistic regression analyses (P less than 0.05).A substantial proportion of women with suspicious mammograms have psychological difficulties, even after learning that they do not have cancer. Such sequelae do not appear to interfere with subsequent adherence.