tbuckley/cabot-search huggingface dataset:
Negative chronotropic but no antiarrhythmic effect of (+)- and (-)-naloxone in rats and guinea pigs
Authors: M. Kaschube, H. Brasch
Journal: Cardiovascular Research (1991)

The aim was to investigate the antiarrhythmic effects of (+)- and (-)-naloxone in various arrhythmia models in vivo.Naloxone (1-40 mg.kg-1), naltrexone (20-40 mg.kg-1), or standard antiarrhythmic drugs (quinidine, lignocaine, phenytoin, (+)-sotalol) were injected intravenously. Ventricular extrasystoles were then elicited by infusion of either ouabain (guinea pigs) or aconitine (rats), or by electrical stimulation (guinea pigs).Male Wistar rats and guinea pigs (n = 6-10) were used. Arterial blood pressure and ECG were recorded continuously.Naloxone and naltrexone decreased the heart rate. The effect of naloxone was not stereospecific and is apparently not mediated by opioid receptors. Naloxone had no influence on ouabain induced arrhythmias or fibrillation threshold in guinea pigs. The appearance of aconitine induced extrasystoles was accelerated by 20 mg.kg-1 (-)-naloxone but delayed by 40 mg.kg-1. No effects were seen with (+)-naloxone or (-)-naltrexone.The results show that naloxone does not possess prominent antiarrhythmic properties.
Failure to screen may be a false economy
Authors: P Harrison, F A Ala, D W Milligan, S Skidmore
Journal: BMJ (1996)

EDITOR,—We have recently seen a case of acute adult T cell leukaemia/lymphoma that leads us to support A Pagliuca and colleagues' call for a reappraisal of screening of blood donors for human T cell leukaemia/lymphoma virus type I (HTLV-I).1

A 47 year old white man presented with hypercalcaemia, a rash, dyspnoea, and lung infiltrates on chest radiography. Skin biopsy and serological testing confirmed the …
RAF1 mutations in childhood-onset dilated cardiomyopathy
Authors: Perundurai S Dhandapany, Abdur Razzaque, Uthiralingam Muthusami, Sreejith Kunnoth, Jonathan J Edwards, Sonia Mulero-Navarro, Ilan Riess, Sherly Pardo, Jipo Sheng, Deepa Selvi Rani, Bindhu Rani, Periyasamy Govindaraj, Elisabetta Flex, Tomohiro Yokota, Michiko Furutani, Tsutomu Nishizawa, Toshio Nakanishi, Jeffrey Robbins, Giuseppe Limongelli, Roger J Hajjar, Djamel Lebeche, Ajay Bahl, Madhu Khullar, Andiappan Rathinavel, Kirsten C Sadler, Marco Tartaglia, Rumiko Matsuoka, Kumarasamy Thangaraj, Bruce D Gelb
Journal: Nature Genetics (2014)
THE HISTORY OF MEDICAL LICENSURE
Authors: HENRY E. SIGERIST
Journal: JAMA (1935)

The idea of making the practice of medicine dependent on a license, a certificate issued by a competent body testifying that the bearer has undergone a training considered adequate, is an idea that originated in the Middle Ages. The European Middle Ages created an institution that was modified in the course of time but survived in its basic idea to the present day. The idea of licensing the medical profession resulted from the general structure of medieval society, which was strictly organized according to status, crafts, trades and professions. Each such vocational group had regulations, standard-setting codes, guaranteeing highly qualified services to society. It was recognized that such standards were particularly important in the case of the medical profession. In no other profession is lack of knowledge so serious in its consequences as in medicine. A wrong legal judgment can be corrected by a higher court. A wrong diagnosis or
Evaluation of Adenovirus Vectors Containing Serotype 35 Fibers for Vaccination
Authors: Nelson DiPaolo, Shaoheng Ni, Anuj Gaggar, Robert Strauss, Sebastian Tuve, Zong Yi Li, Daniel Stone, Dmitry Shayakhmetov, Nancy Kiviat, Papa Touré, Salif Sow, Branka Horvat, André Lieber
Journal: Molecular Therapy (2006)

In contrast to commonly used serotype 5-based adenovirus (Ad) vectors, Ad's containing fibers derived from B-group serotype 35 (Ad5/35) efficiently transduce human DCs ex vivo and appear to target antigen-presenting cells after intravenous injection into baboons. Based on this, Ad5/35 vectors could be valuable tools for immunotherapy and vaccination. On the other hand, a number of studies indicate that signaling through the B-group Ad receptor, CD46, can cause tolerance or immunosuppression. Since mice do not express CD46 in a human-like pattern, we studied the in vivo properties of Ad5/35 in transgenic mice that express CD46 in a pattern and at a level similar to those of humans. Hypersensitivity assays and analyses of frequencies of regulatory T cells and T cell responses did not indicate that Ad5/35 injection exerts detrimental effects on the host's immune system. An Ad5/35 vector expressing a model antigen was able to trigger a strong T cell response against the test antigen after intramuscular injection. Overall, compared to Ad5 vectors, Ad5/35 vectors had a better safety profile, reflected by lower serum levels of proinflammatory cytokines.
Reviews and Notes: Harrison's Principles of Internal Medicine
Authors: Robert P. Ferguson
Journal: Annals of Internal Medicine (1995)

Literature of Medicine15 January 1995Reviews and Notes: Harrison's Principles of Internal MedicineRobert P. Ferguson, MDRobert P. Ferguson, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-2-199501150-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Harrison's Principles of Internal MedicineThirteenth edition. K. J. Isselbacher, E. Braunwald, J. B. Martin, A. S. Fauci, J. D. Wilson, and D. L. Kasper; eds. 2048 pages. New York: McGraw-Hill; 1994. Single volume, $98.00; Two-volume set, $125.00.According to publishing statistics, Harrison's Principles of Internal Medicine has traditionally been one of the two most popular internal medicine textbooks. Its successful style has been maintained in the 13th edition, which begins with an introduction to clinical medicine followed by 290 pages dealing with the cardinal manifestations of diseases. These pages, organized according to symptoms and dysfunctions, is a good beginning ... Author, Article, and Disclosure InformationAuthors: Robert P. Ferguson, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1995Volume 122, Issue 2 Page: 158-159 Keywords AIDS Clinical epidemiology HIV clinical manifestations Infectious disease immunology Infectious diseases Neurology Research laboratories Stroke Viral diseases Viral transmission and infection ePublished: 15 August 2000 Issue Published: 15 January 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A Query on Serum Treatment.
Authors: J. A. Crook
Journal: JAMA (1897)

Jackson, Tenn., Sept. 9, 1897. <h3>To the Editor:</h3> —Since it appears that the serum of the blood taken from those who have typhoid fever will destroy the typhoid bacillus, is it not reasonable to suppose that serum taken from those who have just recovered from the disease and inserted into the blood or tissues of those who have it, may prove a remedy for the disease? Or, for fear of contamination from the blood of those who had it, may not the typhoid bacillus be injected into the horse or cow and the serum taken from those animals and injected into the blood or tissues of typhoid patients prove to be an antitoxin to the disease?
Long-term histologic and virologic outcomes of acute self-limited hepatitis B
Authors: Nobukazu Yuki, Takayuki Nagaoka, Masatoshi Yamashiro, Kiyoshi Mochizuki, Akira Kaneko, Keiji Yamamoto, Masao Omura, Kazumasa Hikiji, Michio Kato
Journal: Hepatology (2003)

The long-term impact of acute self-limited hepatitis B on the liver is unknown. Fourteen patients were recalled at a median of 4.2 years (range, 1.8-9.5 years) after the onset of acute hepatitis B. All showed clinical and serologic recovery with circulating hepatitis B surface antigen (HBsAg) clearance. Antibody to HBsAg (anti-HBs) had developed in 12 patients. Nine underwent liver biopsies at a median of 7.2 years, and histologic findings were evaluated using Ishak scores. Serum samples and frozen liver tissue were subjected to real-time detection polymerase chain reaction (PCR) to quantify the surface and X regions of the hepatitis B virus (HBV) genome and qualitative PCR to detect the covalently closed circular (ccc) HBV DNA replicative intermediate. Three patients had low levels of circulating HBV DNA up to 8.9 years after the onset, whereas both HBV DNA surface and X regions were found in the liver of all 9 patients examined, including 7 negative for serum HBV DNA. Liver viral loads assessed by the 2 regions showed a significant correlation (r = 0.946; P =.008), and all patients tested positive for ccc HBV DNA. Liver fibrosis and mild inflammation persisted in 8 patients. The fibrosis stage had relation to peak serum HBV DNA in the acute phase (P =.046) but not to liver viral loads in the late convalescent phase. In conclusion, occult HBV infection persists in the liver and is accompanied by abnormal liver histology for a decade after complete clinical recovery from acute self-limited hepatitis B.
Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins.
Authors: S J Korsmeyer, A Arnold, A Bakhshi, J V Ravetch, U Siebenlist, P A Hieter, S O Sharrow, T W LeBien, J H Kersey, D G Poplack, P Leder, T A Waldmann
Journal: Journal of Clinical Investigation (1983)

We have explored the relationship among immunoglobulin gene rearrangement, cytoplasmic immunoglobulin production, and cell surface antigen expression within 37 cases of acute lymphocytic leukemia. All 12 cases of the T cell type had germ-line kappa and lambda genes and 11 of 12 had germ-line heavy chain genes. In contrast, all 25 cases of the "non-T, non-B" classification, which lacked both definitive T cell markers and surface immunoglobulin, had rearranged immunoglobulin genes, indicating that they represent precursor cells already committed to the B cell lineage at the gene level. 14 had rearranged heavy chain genes, yet retained germ-line light chain genes, whereas 11 cases had both heavy and light chain gene reorganizations. All patterns of immunoglobulin gene rearrangement predicted by a model that proceeds from heavy chain gene recombination to light chain genes were observed. Despite the uniform presence of rearranged immunoglobulin genes, only five cases produced cytoplasmic mu-chain, one exceptional case produced gamma-chain, and another produced only lambda-chain. The cases of B cell precursor type that do not produce immunoglobulin may represent cells that frequently possess ineffectively rearranged immunoglobulin genes. Included in this group may be a set of cells trapped within the B cell precursor series because their ineffective rearrangements have eliminated certain gene subsegments necessary for the assemblage of an effective heavy chain gene. All seven cases of the non-T, non-B subgroup that bore HLA-DR but lacked CALLA (the common acute lymphocytic leukemia-associated antigen) represented the earliest recognizable stage of B cell precursors with rearranged heavy chain genes but germ-line light chain genes. Correlations here suggest that cells entering B cell development express HLA-DR and rearrange heavy chain genes before the expression of a B cell-associated antigen recognized by the antibody BA-1, the antigen CALLA, and any subsequent light chain gene rearrangements.
Differentiation of subpopulations of human and murine hemopoietic stem cells by hypotonic lysis.
Authors: E Niskanen, M J Cline
Journal: Journal of Clinical Investigation (1980)

Both human and mouse bone marrow contain subpopulations of hemopoietic stem cells that greatly vary in their resistance to water exposure: The cells forming erythroid colonies or bursts in methyl cellulose in vitro are most sensitive to hypotonic conditions and are destroyed within 60 s in the hypotonic milieu. The murine pluripotent stem cells assayed by the spleen colony technique, as well as both murine and human myeloid stem cells assayed by the plasma clot diffusion chamber technique, displayed intermediate sensitivity and were nearly completely eliminated by 120 s of exposure to water. Both human and mouse bone marrow stem cells producing myeloid colonies in agar are most resistant to hypotonic conditions. The addition of monocyte-macrophages and lymphoid cells to water-exposed mouse bone marrow cell populations to compensate for losses did not restore either erythroid or myeloid colony formation.
Transmyocardial gradient of proinflammatory cytokines in patients with decompensated idiopathic dilated cardiomyopathy
Authors: Hyuk-Jae Chang, Joon-Han Shin, So-Yeon Choi, Gyo-Seung Hwang, Myeong-Ho Yoon, Han-Soo Kim, Seung-Jea Tahk, Hae-Sim Park, Byung-il W. Choi
Journal: Journal of the American College of Cardiology (2002)
Lithium as an Adjunct to Radioactive Iodine in Treatment-Resistant Graves Thyrotoxicosis
Authors: K. Hoogenberg
Journal: Annals of Internal Medicine (1998)

Letters15 October 1998Lithium as an Adjunct to Radioactive Iodine in Treatment-Resistant Graves ThyrotoxicosisK. Hoogenberg, MD, PhD, J.A.M. Beentjes, MD, and D.A. Piers, MD, PhDK. Hoogenberg, MD, PhDState University Hospital; Gronigen, the NetherlandsSearch for more papers by this author, J.A.M. Beentjes, MDState University Hospital; Gronigen, the NetherlandsSearch for more papers by this author, and D.A. Piers, MD, PhDState University Hospital; Gronigen, the NetherlandsSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-8-199810150-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Lithium has been documented to increase retention of radioactive iodine131 I) in the thyroid of patients with Graves thyrotoxicosis [1]. By prolongation of thyroidal exposure time to 131I, lithium may increase the effectiveness of such therapy. In particular, patients with a rapid thyroid iodine turnover, a condition associated with 131I treatment failure [2], may benefit from the 131I-potentiating effects of lithium. Here, we report on the value of lithium pretreatment in a patient with apparent 131I-resistant Graves thyrotoxicosis.A 47-year-old woman had had relapsing Graves thyrotoxicosis for 10 years. She had been treated with the antithyroid drug ...References1. Turner JG, Brownlie BE, Rogers TG. Lithium as an adjunct to radioiodine therapy for thyrotoxicosis. Lancet. 1976; 1:614-5. Google Scholar2. Aktay R, Rezai K, Seabold JE, Bar RS, Kirchner PT. Four- to twenty-four-hour uptake ratio: an index of rapid iodine-131 turnover in hyperthyroidism. J Nucl Med. 1996; 37:1815-9. Google Scholar3. Shapiro B. Optimization of radioiodine therapy of thyrotoxicosis: what have we learned after 50 years? J Nucl Med. 1993; 34:1638-41. Google Scholar Author, Article, and Disclosure InformationAuthors: K. Hoogenberg, MD, PhD; J.A.M. Beentjes, MD; D.A. Piers, MD, PhDAffiliations: State University Hospital; Gronigen, the Netherlands PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLithium2016 Guidelines for the management of thyroid storm from The Japan Thyroid Association and Japan Endocrine Society (First edition)Radioiodine Treatment in Patients with Graves’ DiseaseRefractory Graves' Disease Successfully Cured by Adjunctive Cholestyramine and Subsequent Total ThyroidectomyLithium carbonate plus 131I in the treatment of Graves’ hyperthyroidismANTIDEPRESSANTSENDOCRINE AND METABOLIC ADVERSE EFFECTS OF NON-HORMONAL AND NON-METABOLIC DRUGSLithiumLithium 15 October 1998Volume 129, Issue 8Page: 670KeywordsBlood plasmaDrugsHypothyroidismPatientsPeroxidasesRadiation therapyThyroidThyroid-stimulating hormoneThyroidectomyThyroxine ePublished: 15 August 2000 Issue Published: 15 October 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Sudden Death in a Patient on a Liquid Protein Diet
Authors: Robert R. Michiel, Jeffrey S. Sneider, Richard A. Dickstein, Harvey Hayman, Robert H. Eich
Journal: New England Journal of Medicine (1978)

SUDDEN death in adults without serious underlying heart disease has emerged as a major complication of the liquid protein diets.1,2 Fifteen such cases have been reported to the Center for Disease Control and the Food and Drug Administration since July 1, 1977. This communication describes the course of one of these patients who was admitted to the Upstate Medical Center with intractable ventricular arrhythmias. The findings on post-mortem examination of the heart, skeletal muscle and liver are compatible with starvation.Case ReportA 38-year-old woman was admitted to Crouse-Irving Memorial Hospital on October 22, 1977, complaining of syncopal episodes. In . . .
Peptide, peptidomimetic, and organic synthetic combinatorial libraries
Authors: Jutia Eichler, Jon R. Appel, Sylvie E. Blondelle, Colette T. Dooley, Barbara Döurner, John M. Ostresh, Enrique Péarez‐Payá, Clemencia Pinilla, Richard A. Houghten
Journal: Medicinal Research Reviews (1995)
Percutaneous Transhepatic Choledochoplasty and Dilatation of Choledochoenterostomy Strictures
Authors: Steven K. Teplick
Journal: JAMA (1980)

IN RECENT years, percutaneous transluminal angioplasty has become recognized as a useful, safe procedure for the treatment of peripheral vascular disease.<sup>1-3</sup>The introduction of the Gruntzig balloon catheter has extended the applications of percutaneous angioplasty to include dilatations of renal arteries in patients with renovascular hypertension and of coronary arteries in patients with coronary artery disease.<sup>4-6</sup> Balloon catheters also have been used to dilate strictures in other areas of the body such as the genitourinary and gastrointestinal tracts as well as the biliary system. Dilatation of bile duct strictures by balloon catheter has been reported,<sup>7</sup>and balloon choledochoplasty possibly could be as useful as balloon angioplasty. The following case report is an example of its usefulness. <h3>Report of a Case</h3> A 67-year-old man underwent cholecystectomy in May 1978 for cholecystitis and jaundice. At surgery, a partial obstruction of the common hepatic duct just distal to the hepatic duct bifurcation
The Radiological Evaluation of Hepatic Cavernous Hemangioma
Authors: William E. Brant
Journal: JAMA (1987)

CAVERNOUS hemangiomas of the liver are sufficiently common that they will often be incidentally discovered during hepatic imaging by ultrasound, computed tomography, or radiocolloid scintigraphy. The differentiation of these benign tumors from primary or metastatic hepatic malignancy is mandatory, but often it is not possible on the study in which the lesion was originally detected. There are several routes by which to arrive at the correct diagnosis, but the optimum study or sequence of studies may elude the physician caring for the patient. Knowledge of the imaging options, and the strengths and weaknesses of each of these options, will facilitate a rapid diagnosis and ensure proper treatment, with maximum patient safety and minimum expenditure of resources. <h3>RADIOLOGICAL METHODS Nuclear Medicine</h3> The routine liver-spleen scan utilizing technetium 99m sulfur colloid offers little help in differentiating cavernous hemangiomas from other space-occupying lesions of the liver. In addition, its sensitivity in detecting lesions
Drug Delivery: Sustained Zero‐Order Release of Intact Ultra‐Stable Drug‐Loaded Liposomes from an Implantable Nanochannel Delivery System (Adv. Healthcare Mater. 2/2014)
Authors: Christian Celia, Silvia Ferrati, Shyam Bansal, Anne L. van de Ven, Barbara Ruozi, Erika Zabre, Sharath Hosali, Donatella Paolino, Maria Grazia Sarpietro, Daniel Fine, Massimo Fresta, Mauro Ferrari, Alessandro Grattoni
Journal: Advanced Healthcare Materials (2014)

Metronomic chemotherapy supports the idea that long-term administration of chemotherapeutics could be effective against numerous cancers. On page 230, Alessandro Grattoni and colleagues present constant and sustained release of ultrastable drug-loaded liposomes from an implantable nanochannel delivery system over 18 days. Further, liposome intravasation from subcutaneous delivery is investigated and their biological activity post-nanochannel release on BT474 breast cancer cells is verified.
Primary Systemic (Amyloid Light-Chain) Amyloidosis Masquerading as Pseudoxanthoma Elasticum
Authors: Heidi Wat, Douglas C. Wu, Muhammad N. Mahmood, Alain Brassard
Journal: JAMA Dermatology (2014)

<h3>Importance</h3> Primary systemic (amyloid light-chain [AL]) amyloidosis has a variety of cutaneous manifestations. In this case, we present a novel clinicopathological pattern of AL amyloidosis. <h3>Observations</h3> A woman in her 50s with a history of AL amyloidosis manifesting as macroglossia and bilateral carpal tunnel syndrome presented with skin-colored to yellow cobblestoned plaques to the neck and bilateral antecubital fossa. Although clinical similar to pseudoxanthoma elasticum (PXE), the skin changes were found to be due to amyloid deposition primarily around the pilosebaceous unit but also within the papillary and reticular dermis. Previous reports of PXE-like plaques in AL amyloidosis have been reported as part of a very rare entity termed<i>amyloid elastosis</i>. However, our case demonstrates several important clinical and pathological differences from this entity. Most notably, there was no dermal elastic fiber involvement, limited cutaneous and systemic involvement, and a fairly indolent course with better response to treatment. <h3>Conclusions and Relevance</h3> Identification of this atypical presentation of AL amyloidosis has important implications for early detection and rapid treatment. The lack of elastic fiber involvement establishes the uniqueness of this case, and further study may be required to determine if this histological finding has prognostic significance.
1004 PREDICTIVE CRITERIA FOR THE OUTCOME OF PATIENTS WITH FULMINANT HEPATITIS TREATED WITH MARS. UPDATE
Authors: G. Novelli, V. Morabito, M. Rossi, Q. Lai, R. Pretagostini, F. Pugliese, L. Poli, S. Novelli, P.B. Berloco
Journal: Journal of Hepatology (2013)
Stopping Seizures Early and the Surgical Epilepsy Trial That Stopped Even Earlier
Authors: Donald L. Schomer, Roger J. Lewis
Journal: JAMA (2012)

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Is ENSP (Hev b 13) the missing latex allergen to fill the gap in the repertoire of isolated allergens for the determination of sensitization profiles?
Authors: M.E. Raulf-Heimsoth, H.Y. Yeang, I. Sander, P. Rozynek, S.A.M. Arif, C. Fleischer, R. Cremer, T. Brüning, H. Rihs
Journal: Journal of Allergy and Clinical Immunology (2003)