tbuckley/cabot-search huggingface dataset:
Hodgkin's Disease in External Mammary Lymph Nodes
Authors: J. C. Reverter, N. Viñolas, E. Montserrat, C. Rozman
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 December 1985Hodgkin's Disease in External Mammary Lymph NodesJ. C. REVERTER, M.D., N. VIÑOLAS, M.D., E. MONTSERRAT, M.D., C. ROZMAN, M.D.J. C. REVERTER, M.D.Search for more papers by this author, N. VIÑOLAS, M.D.Search for more papers by this author, E. MONTSERRAT, M.D.Search for more papers by this author, C. ROZMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-6-964_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recently, a report on late relapses in Hodgkin's disease emphasizing the need for a prolonged, careful, and specialized follow-up has appeared in your journal (1). Usually, patients with Hodgkin's disease have relapses in sites of previous disease, extranodally, or in territories contiguous to previously involved sites (2). We describe the case of a patient with a late relapse of a Hodgkin's disease manifested by an isolated lymphadenopathy in the external mammary lymphatic chain, a finding that has never been reported.In February 1980 an 18-year-old woman had been diagnosed as having mixed-cellularity-type Hodgkin's disease, stage IVB, involving...References1. HERMAN T, HOPPE R, DONALDSON S, COX R, ROSENBERG S, and KAPLAN H. Late relapse among patients treated for Hodgkin's disease. Ann Intern Med. 1985;102:292-7. LinkGoogle Scholar2. YOUNG R, CANELLOS G, CHABNER B, HUBBARD S, and DEVITA V. Patterns of relapse in advanced Hodgkin's disease treated with combination chemotherapy. Cancer. 1978;42:1001-7. CrossrefMedlineGoogle Scholar3. KAPLAN H. Hodgkin's Disease. 2nd ed. Cambridge, Massachusetts: Harvard University Press; 1984. Google Scholar4. FIRTH L. Hodgkin's disease presenting at the elbow. Lancet. 1978;2:111. CrossrefMedlineGoogle Scholar5. GOLDMAN J. Parasternal chest wall involvement in Hodgkin's disease. Chest. 1971;59:133-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. C. REVERTER, M.D.; N. VIÑOLAS, M.D.; E. MONTSERRAT, M.D.; C. ROZMAN, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1985Volume 103, Issue 6_Part_1Page: 964-964KeywordsHodgkin lymphomaLymph nodes ePublished: 1 December 2008 Issue Published: 1 December 1985 PDF downloadLoading ...
Dissemination of Information on Hypertension
Authors: Valerie Gilchrist
Journal: JAMA (1982)

To the Editor.—  Jeoffrey K. Stross, MD, and William R. Harlan, MD, stated that they assessed knowledge of the findings of the Hypertension Detection and Follow-up Program (HDFP) in family physicians and internists at two months and six months, respectively (1981;246:360). Because of this, any comparison between the two groups as groups of physicians that differ in fields of specialization is inappropriate. However, they publish in table form, specifically Table 2, a comparison of such with a P value as listed. Listing a P value represents a misuse of statistical inference. It is rather like posing a mathematical problem to left-handed students and right-handed students and then listing a P value referring to only the hand dominance without mentioning that one group of students was in the third grade while the other was in the fourth grade. Statistical comparison should only be made between two groups that differ in only
Reactive arthritis attributable to Shigella infection: a clinical and epidemiological nationwide study
Authors: T Hannu
Journal: Annals of the Rheumatic Diseases (2004)

To study the incidence and clinical picture of Shigella associated reactive arthritis (ReA) and the arthritogenicity of various Shigella species in the population.A questionnaire on enteric and extraintestinal, especially musculoskeletal, symptoms was sent to 278 consecutive patients with Shigella positive stool culture and to 597 controls. Analysis of self reported musculoskeletal symptoms was supplemented with clinical examination of those subjects with recent symptoms.Of the patients, 14/211 (7%) had ReA, and a further 4/211 (2%) other reactive musculoskeletal symptoms (tendonitis, enthesopathy, or bursitis). Of the 14 patients with ReA, all adults, 10 had S sonnei, three S flexneri, and one S dysenteriae infection. HLA-B27 was positive in 36% of the patients with ReA. One control subject had ReA. In the patients with Shigella infection, the odds ratio for developing ReA was 16.2 (95% confidence interval 2.1 to 123.9), p = 0.001.ReA occurred in 7% of patients after Shigella infection, with an annual incidence of 1.3/1 000 000 in Finland. Besides S flexneri, S sonnei and S dysenteriae can also trigger ReA.
Reactivity to IgE‐dependent histamine‐releasing factor is due to monomeric IgE
Authors: I. Kleine Budde, M. Aalbers, R. C. Aalberse, J. S. Van Der Zee, E. F. Knol
Journal: Allergy (2000)

Background : IgE‐dependent histamine‐releasing factor (HRF) can distinguish between IgE + and IgE − . In contrast to IgE − , IgE + sensitizes basophils to release histamine in response to HRF. But we do not know what particular feature distinguishes IgE + from IgE − . The objective was to investigate the hypothesis that IgE + is polymeric IgE. Methods : IgE + plasma was separated by size‐exclusion chromatography. The basophil‐sensitizing capacity of the fractions was analyzed in response to HRF produced by mononuclear cells. Results : We showed that monomeric IgE sensitized basophils to release histamine in response to HRF and to house‐dust mite, whereas no enhanced reactivity was found in the fractions containing polymeric IgE. Conclusions : HRF reacts with monomeric IgE, and not (exclusively) with polymeric IgE.
Delayed Hospital Presentation in Patients Who Have Had Acute Myocardial Infarction
Authors: Jerry H. Gurwitz
Journal: Annals of Internal Medicine (1997)

Background: In patients who have had acute myocardial infarction, the delay between the onset of symptoms and hospital presentation is a critical factor in determining the initial management strategy and outcomes of treatment. Objective: To examine the determinants of delayed hospital presentation in patients who have had acute myocardial infarction. Design: Retrospective chart review. Setting: 37 hospitals in Minnesota. Patients: 2409 persons hospitalized with acute myocardial infarction between October 1992 and July 1993. Main Outcome Measure: Hospital presentation delayed more than 6 hours after the onset of symptoms of acute myocardial infarction. Results: Information on length of delay was available for 2404 patients. Of these patients, 969 (40%) delayed presentation to the hospital for more than 6 hours after the onset of symptoms. Factors associated with prolonged delay included advanced age and female sex. The presence of chest discomfort and a history of mechanical revascularization significantly reduced the risk for prolonged delay. Risk for delay was greatest during the evening and early morning hours (6:00 p.m. to 6:00 a.m.) Patients with a history of hypertension were more likely to delay presentation. Only 42% of all patients hospitalized with acute myocardial infarction had used emergency medical transport services. Conclusions: Patients who have had acute myocardial infarction often delay hospital presentation. Educational interventions that encourage the prompt use of emergency medical transport services and target specific patient populations, such as elderly persons, women, and persons with cardiac risk factors, may be most successful in reducing the length of delay and improving the outcomes of patients with acute myocardial infarction.
WHY NOT SIMILAR SCHOOLS FOR THE CAUCASIAN?
Authors: William Allen Pusey
Journal: JAMA (1930)

To the Editor:  —InThe Journal, June 7, page 1849, is an account of the new Meharry Medical School at Nashville, in which one significant and interesting point is emphasized. Meharry, which has long had a reputation for good and faithful work in the education of Negroes, will have this new plant for 225 medical students, 150 dental students and 100 pharmaceutic students and there will be a hospital of 150 beds. The funds for this institution have been furnished largely by the General Education Board, the Julius Rosenwald Fund, Mr. George Eastman and Mr. Edward Harkness, all old and tried contributors to wise philanthropy. The interesting point in this statement is that there seems to be a departure from established policy, at least from that of the General Education Board, as respects this institution, for the account says: Meharry's efforts will be directed to the training of the Negro
Treatment of cutaneous myiasis associated with scalp psoriasis in a 13-year-old girl with oral ivermectin
Authors: José Juan Pereyra-Rodríguez, José Bernabeu-Wittel, Maria Dolores Conejo-Mir, Maite Ruiz-Pérez de Pipaón, Julián Conejo-Mir
Journal: Journal of the American Academy of Dermatology (2010)
Congenital nephrotic syndrome (NPHS1): Features resulting from different mutations in Finnish patients
Authors: Jaakko Patrakka, Marjo Kestilä, Jorma Wartiovaara, Vesa Ruotsalainen, Päivi Tissari, Ulla Lenkkeri, Minna Männikkö, Ilona Visapää, Christer Holmberg, Juhani Rapola, Karl Tryggvason, Hannu Jalanko
Journal: Kidney International (2000)
Epstein-Barr Virus Associated Large B-Cell Cardiac Lymphoma With Simultaneous Manifestation in the Forearm
Authors: Naser Qedra, Chalid Assaf, Horst Dürkop, Takeshi Komoda, Mahdi Kadry, Roland Hetzer
Journal: Journal of Clinical Oncology (2008)

with low-dose alemtzumab.To our knowledge, this is the first case reported in literature who described eyelid localizations successfully treated with low-dose alemtuzumab.This article has shown that alemtuzumab is an effective option for treatment of LC in patient affected by CLL.In our case, LC developed 8 years after the CLL diagnosis without influencing patient survival. 3The use of low-dose alemtuzumab (10 mg three times a week as target dose) as previously reported [8][9][10][11] reduces the risk of toxicities and infection, especially if the T-helper lymphocyte count was constantly more than 200/mm 3 , and stringent antimicrobial prophylaxis and periodical viral tests were performed during alemtuzumab treatment.This patient probably acquired 17p deletion during the course of the disease because of the long history of disease, and this chromosomal abnormality is reported to be unresponsive to standard chemotherapy, while responsive to alemtuzumab therapy. 12 Using alemtuzumab as the choice of lowdose therapy was due to the fact that, as our patient was 71 years old with a progressive 17p-CLL/LC and three previous line of polichemotherapies, the only therapeutical option was a palliative therapy.Lowdose alemtuzumab (10 mg as target dose; 240 mg as total induction therapy) could allow our patient to obtain a clinical response, reducing the adverse effect of the drug itself because of the expression of CD52 in the surface of T cells and neoplastic B cells.Our patient achieved a minimum of 400/mm 3 T-helper lymphocytes during alemtuzumab therapy, and never experienced unknown fever, infection disease, CMV reactivation, nor pancytopenia, and he never needed hospitalization.Considering the tolerability of low-dose alemtuzumab induction therapy, the high risk of relapse due to biologic data, and the absence of other therapeutical options, we decided to start with a maintenance therapy.After 6 months, the patient is showing persistent resolution of palpebral LC and continuous partial response for CLL, so the manteinance therapy will be continued during the next months.
The Last Surviving Wall
Authors: MAYOLA BOYKIN, MICHAEL F. HARTSHORNE, JOHN M. BAUMAN, BILL F. BYRD
Journal: Clinical Nuclear Medicine (1987)

A total of 66 patients with advanced coronary artery disease (CAD) and 36 with dilated cardiomyopathies (DCM) with ejection fractions less than 20% were analyzed retrospectively to establish patterns of wall motion in each of four quadrants on standard left anterior oblique gated radionuclide ventriculograms. In both disease states the best preserved wall motion was found in the basal free wall quadrant of the left ventricle. The two terminal disease states could not be differentiated on the basis of wall motion patterns.
Mediation of reocclusion by thromboxane A2 and serotonin after thrombolysis with tissue-type plasminogen activator in a canine preparation of coronary thrombosis.
Authors: P Golino, J H Ashton, P Glas-Greenwalt, J McNatt, L M Buja, J T Willerson
Journal: Circulation (1988)

Human recombinant tissue-type plasminogen activator (rt-PA) has been shown to be an effective and safe agent for coronary thrombolysis in patients with acute myocardial infarction. However, thrombolysis is associated with a high rate of acute reocclusion after discontinuation of rt-PA. The goals of the present study were to assess whether reocclusion after thrombolysis is caused by intracoronary platelet aggregation and to determine the role of thromboxane A2 (TxA2) and serotonin (5HT) in mediating this phenomenon. Accordingly, coronary thrombosis was induced in anesthetized, open-chest dogs by insertion of a copper coil into the left anterior descending coronary artery (LAD). LAD blood flow was monitored throughout the experiment by means of a Doppler flow probe placed proximally to the coil. Thrombolysis was achieved with rt-PA (0.05 mg/kg bolus + micrograms/kg/min infusion) in 23 +/- 3 min. rt-PA was then discontinued and each animal received a bolus of heparin (150 U/kg) every hour. Reperfusion was followed by repeated cycles of gradual occlusions followed by spontaneous restorations of blood flow (cyclic flow variations, CFVs) before a persistent occlusion recurred. In control dogs (n = 6), heparin alone did not prevent CFVs and reocclusion time was 25 +/- 4 min. Administration of an intravenous bolus of 0.2 +/- 0.06 mg/kg SQ29548, a TxA2/prostaglandin H2-receptor antagonist, and an intravenous bolus of 0.2 +/- 0.04 mg/kg ketanserin, a 5HT2-receptor antagonist, completely abolished CFVs in six of six dogs and reocclusion time was greater than 158 +/- 14 min (p less than .01).(ABSTRACT TRUNCATED AT 250 WORDS)
Routine Radiography for Haemoptysis
Authors: G. Poole, P. Stradling
Journal: BMJ (1964)

There has also been a very constant pattern of cancer over the six decades as regards site and type.This pattern differs considerably from the European pattern in the infrequency of certain types of cancer and the undue frequency of others.This analysis could not have been interpreted in terms of cancer in Western countries, and it is only modern knowledge of the Uganda cancer pattern which enables comparisons to be made.This is particularly the case with the common lymphomatous tumour of children, which has evidently been commonly seen in Uganda for the last 60 years.There is no evidence that cancer has been uncommon in Uganda since the first days of modern Western medicine, and the stability of the site and type-pattern suggests that it is due to factors embedded in the Uganda African way of life.This investigation has only been r ;ssible because of a very generous research
Predicting Who Dies Depends on How Severity Is Measured: Implications for Evaluating Patient Outcomes
Authors: Lisa I. Iezzoni
Journal: Annals of Internal Medicine (1995)

Objective: To determine whether assessments of illness severity, defined as risk for in-hospital death, varied across four severity measures. Design: Retrospective cohort study. Setting: 100 hospitals using the MedisGroups severity measure. Patients: 11 880 adults managed medically for acute myocardial infarction; 1574 in-hospital deaths (13.2%). Measurements: For each patient, probability of death was predicted four times, each time by using patient age and sex and one of four common severity measures: 1) admission MedisGroups scores for probability of death scores; 2) scores based on values for 17 physiologic variables at time of admission; 3) Disease Staging's probability-of-mortality model; and 4) All Patient Refined Diagnosis Related Groups (APR-DRGs). Patients were ranked according to probability of death as predicted by each severity measure, and rankings were compared across measures. The presence or absence of each of six clinical findings considered to indicate poor prognosis in patients with myocardial infarction (congestive heart failure, pulmonary edema, coma, low systolic blood pressure, low left ventricular ejection fraction, and high blood urea nitrogen level) was determined for patients ranked differently by different severity measures. Results: MedisGroups and the physiology score gave 94.7% of patients similar rankings. Disease Staging, MedisGroups, and the physiology score gave only 78% of patients similar rankings. MedisGroups and APR-DRGs gave 80% of patients similar rankings. Patients whose illnesses were more severe according to MedisGroups and the physiology score were more likely to have the six clinical findings than were patients whose illnesses were more severe according to Disease Staging and APR-DRGs. Conclusions: Some pairs of severity measures assigned very different severity levels to more than 20% of patients. Evaluations of patient outcomes need to be sensitive to the severity measures used for risk adjustment.
THE PATHOGENESIS OF GOUT.
Authors: HANS FROELICH
Journal: JAMA (1897)

Garrod demonstrated in 1848 with his thread test the presence of uric acid in the blood in gout, and basing himself upon this fact, said that in gout there was reduced capacity of the kidneys to pass uric acid; and second, that the alkalescence of the humors in gout was decreased. Charcot believed in an increased production of uric acid, caused by a functional disturbance of the liver, and Cantani thinks that the uric acid originates in the cartilages themselves, and believes that the uric acid diathesis is the consequence of disturbance in the nutrition of the cartilages, the ligaments and the tendons near the bone. The scientific researches in gout and kindred diseases had for forty years been under the ban of Garrod's discovery; all the immense work done within this span of time has been in vain, of no practical value, because now we know that not only
Corrigendum to “Enhancing drug absorption using lipids: A case study presenting the development and pharmacological evaluation of a novel lipid-based oral amphotericin B formulation for the treatment of systemic fungal infections” [Advanced Drug Delivery Reviews 60 (2008)692–701]
Authors: Kristina Sachs-Barrable, Stephen D. Lee, Ellen K. Wasan, Sheila J. Thornton, Kishor M. Wasan
Journal: Advanced Drug Delivery Reviews (2008)
Heat Shock Protein 47 Is Expressed in Fibrous Regions of Human Atheroma and Is Regulated by Growth Factors and Oxidized Low-Density Lipoprotein
Authors: Edward Rocnik, Lawrence H. Chow, J. Geoffrey Pickering
Journal: Circulation (2000)

Background —Heat shock protein 47 (Hsp47) is a stress protein that may act as a chaperone for procollagen. Its involvement in atherosclerosis is unknown. Methods and Results —Hsp47 expression in human coronary arteries was assessed by immunostaining. Strong focal expression was evident in atherosclerotic, but not normal, arteries and was prevalent in the collagenous regions. Double immunostaining revealed that all cells expressing type I procollagen also expressed Hsp47. Moreover, parallel regulation of proα1(I)collagen and Hsp47 mRNA expression occurred with cultured human smooth muscle cells stimulated with transforming growth factor-β1 or fibroblast growth factor-2. However, a proportion of Hsp47-expressing cells in plaque did not express type I procollagen, and this pattern could be reproduced in culture. Heat shock and oxidized LDL stimulated the expression of Hsp47 mRNA by smooth muscle cells, without a concomitant rise in proα1(I)collagen expression. Conclusions —These findings identify Hsp47 as a novel constituent of human coronary atheroma. Its localization to the fibrous cap, regulation by growth factors in parallel with type I procollagen, and selective upregulation by stress raise the possibility that Hsp47 is a determinant of plaque stability.
THE DIAGNOSIS AND TREATMENT OF MASTOIDITIS.
Authors: EDWARD B. DENCH
Journal: JAMA (1901)

In any case of acute or chronic middle ear inflammation, where there is a collection of pus within the middle ear, there is danger of extension of the inflammation to the mastoid cells. It is a question whether the mastoid is not involved to some extent in all cases of acute middle ear inflammation, as well as in all cases in which a chronic suppuration of the middle ear has existed for a considerable period of time. Naturally this statement is not meant to imply that the mastoid involvement requires any interference on the part of the surgeon, the condition disappearing on appropriate treatment of the middle ear. It is hardly conceivable, however, that in two regions so closely associated and so intimately connected as the pneumatic spaces of the mastoid and the tympanum, one part could be the seat of an inflammatory process without some slight extension to the
On LEAD ENCEPHALOPATHY and the USE of DIACHYLON as an ABORTIFACIENT
Authors: W. B. Ransom
Journal: BMJ (1900)

solids.The muscle was stained by Marchi method, and shows that quite one half of the fibres have undergone acutefatty degeneration.The dense black masses are fat cells; but the degenerated muscle fibres are indicated by the diffuse black staining.The musculi papillares of the heart showed even more marked fatty degeneration.
Who Shall Study Medicine?
Authors: Marlene R. Duwell
Journal: JAMA (1981)

<h3>To the Editor.—</h3> Bravo Dr Blum! Your COMMENTARY is an absolute masterpiece. Those of us in undergraduate curriculums constantly face the task of second guessing whether it is more important to major in science or to turn to the well-rounded liberal arts. It is unfortunate that many like myself leave the liberal arts and all of its useful worldly knowledge to twist, bend, and funnel our minds in the direction we hope will be most pleasing to the admissions panel of a medical school. It is disappointing that we must often give up a course in music or art appreciation to study harder for a science course to make the "almighty grade," rather than learning a little more appreciation for the world we will work in everyday. That is not to say we do not enjoy the curricula we have chosen, but how much fuller our lives might be if