tbuckley/cabot-search huggingface dataset:
Septic Arthritis
Authors: James D. C. Gowans, Philip A. Granieri
Journal: New England Journal of Medicine (1959)

THE first intra-articular injection of hydrocortisone has been credited to Thorn. The first demonstration of this procedure as a practical and effective therapeutic technic was by Hollander et al.1 , 2 in 1951. These investigators presented carefully compiled data clearly demonstrating the ameliorating effects of locally injected hydrocortisone in a variety of painful and inflammatory disorders of joints and bursas. The response was shown to be temporary in most cases, but the procedure has proved helpful as a stopgap method of relieving acute exacerbations involving one or a few joints, even though precise indications for injection have not been established.Since the . . .
How Molecular Diagnosis Can Change Allergen-specific Immunotherapy Prescription In A Complex Area Of Pollen Sensitization (madrid, Spain)
Authors: M. Landivar Encalada, V. Andregnette Roscigno, M. Ruiz Garcia, E. Hernandez Garcia De La Barrera, J. Sastre Dominguez
Journal: Journal of Allergy and Clinical Immunology (2012)
Therapy for Hypercholesterolemia; Standardization of Cholesterol Measurements-Reply
Authors: Robert I. Levy
Journal: JAMA (1990)

<h3>In Reply. —</h3> The issue raised by Dr Hamburger is an important one, and it was considered in our review. We stated that "bile acid sequestrants can interfere with the absorption of concurrently administered drugs." Limits on the length of our article precluded greater detail. Since the bile acid sequestrants are anion exchange resins, they have the potential to interfere with the absorption of anionic drugs. Such an interaction has been demonstrated for thyroxine, phenylbutazone, warfarin, chlorothiazide, propranolol, digoxin, tetracycline, and penicillin G. This interaction certainly exists with many other anionic drugs that have not yet been tested. It is, therefore, prudent to administer other medication at least 1 hour before or 4 hours after dosing with a bile acid sequestrant. If this precaution is not observed, marked changes in blood levels of concurrently administered medications may occur when treatment with a bile acid sequestrant is initiated or discontinued. Patients
HOW OFTEN IS LEFT MAIN OR LEFT ANTERIOR DESCENDING ARTERY THE CULPRIT VESSEL IN PATIENTS PRESENTING WITH NEW OR PRESUMED NEW LEFT BUNDLE BRANCH BLOCK AND SUSPECTED ACUTE CORONARY SYNDROME?
Authors: Pranav Kansara, Subba Reddy Vanga, Sandra Weiss, Ehsanur Rahman, William S. Weintraub
Journal: Journal of the American College of Cardiology (2014)
A Case-Control Study of Routine and Death Scene Sleep Position and Sudden Infant Death Syndrome in Southern California
Authors: Hillary Sandra Klonoff-Cohen, Sharon Leigh Edelstein
Journal: JAMA (1995)

<h3>Objective.</h3> —To investigate whether infants who died of sudden infant death syndrome (SIDS) were routinely placed in different sleep positions compared with healthy infants in a multiethnic diverse population in the United States. <h3>Design.</h3> —A population-based case-control study. <h3>Setting.</h3> —Five counties in Southern California including Los Angeles, Orange, San Bernardino, Riverside, and San Diego. <h3>Participants.</h3> —Parents of 200 white, African-American, Hispanic, and Asian infants who died of SIDS between January 1989 and December 1992 and parents of 200 healthy, living infants matched on the basis of birth hospital, birth date, race, and gender. Information was obtained from detailed telephone interviews with the parents and validated with obstetric and pediatric records. <h3>Main Outcome Measures.</h3> —Routine sleep position, type of bedding, and objects in bed were determined for both case and control infants, while the last-placed and found sleep and face positions at death were reported for SIDS infants. <h3>Results.</h3> —Approximately 66% of SIDS infants and 64% of comparison infants routinely slept on their abdomens (<i>P</i>=.91). At the time of death, 80% of cases were found sleeping on their abdomens. There was no difference in routine sleep position for SIDS infants and comparison infants (odds ratio=0.76; 95% confidence interval, 0.42 to 1.38), while simultaneously adjusting for birth weight (in grams), medical conditions at birth, breast-feeding, passive smoking, maternal recreational drug use, prenatal care, and infant vomiting. Hispanic parents routinely placed their infants on their abdomens less frequently than white parents (<i>P</i>&lt;.01). However, the prone sleep position (face down) was the most commonly found sleep position at death in both Hispanic and non-Hispanic infants. <h3>Conclusions.</h3> —Routine prone sleep position was not associated with an increased risk of SIDS in this study population. The results need to be confirmed with other parents of SIDS infants interviewed before the height of publicity regarding prone sleep position in the United States. (<i>JAMA</i>. 1995;273:790-794)
ILEO-CAECAL VOLVULUS FROM ADHESIONS FORMED BY LEFT-SIDED PELVIC APPENDICITIS
Authors: W. A. Cochrane
Journal: BMJ (1929)

a percussion wave, wlhich, arising at the aortic orifice, qitodam m1odo, courses through the arteries at the rate of about 7 mnetres per seconid, whereas the blood streami is never faster than 0.5 metre per second.*It must be olbvious that these two velocities cannot be effectivelv lharinessed to the end of one co-operative act.That which the finger on the artery takes niote of, tlhen, is the passage of a -wave, and the imression gaiined is that of a lift, whichl is confirmed by phvsiologists, who teach that iii the act of passing the artery is expandlde(l 0d lenigthened.Evidenitly the wave carries force.Now let us take the stage of equipioise between.the intra- arterial pressure-that is, the pr essuree caused by the arterial elastic recoil-and the opposing mnoaiiometer pres-
The Present Status of Antimalarial Drugs
Authors: L. Everard Napier
Journal: New England Journal of Medicine (1945)

IN RECENT years much has been learned concerning the use of antimalarial drugs. The significant changes that have occurred will be discussed in the following paragraphs.Atabrine Pre-Pearl Harbor Status At the beginning of 1942, there were a large group of clinicians who had had ten years' practical experience with atabrine (quinacrine, U.S.P.: mepacrin B.P.). Many of these were enthusiastic about the drug, not only because it provided an alternative drug for the treatment of malaria, but because they believed that it had definite advantages over quinine in the therapy, and certainly in the so-called "suppression," of malaria. If . . .
Results From a Single-Blind, Randomized Study Comparing the Impact of Different Ablation Approaches on Long-Term Procedure Outcome in Coexistent Atrial Fibrillation and Flutter (APPROVAL)
Authors: Sanghamitra Mohanty, Prasant Mohanty, Luigi Di Biase, Rong Bai, Pasquale Santangeli, Michela Casella, Antonio Dello Russo, Claudio Tondo, Sakis Themistoclakis, Antonio Raviele, Antonio Rossillo, Andrea Corrado, Gemma Pelargonio, Giovanni Forleo, Andrea Natale
Journal: Circulation (2013)

Background— This study examined the impact of different ablation strategies on atrial fibrillation (AF) recurrence and quality of life in coexistent AF and atrial flutter (AFL). Methods and Results— Three-hundred sixty enrolled patients with documented AF and AFL were blinded and randomized to group 1, AF±AFL ablation (n=182), or group 2, AFL ablation only (n=178). AF recurrence was evaluated with event recording and 7-day Holter at 3, 6, 9, and 12-month follow-ups. Quality of life was assessed at baseline and at the 12-month follow-up with 4 questionnaires: the Medical Outcome Study Short Form, the Hospital Anxiety and Depression Score, the Beck Depression Inventory, and the State-Trait Anxiety Inventory. Of the 182 patients in group 1, 58 (age, 63±8 years; 78% male; left ventricular ejection fraction, 59±8%) had AF+AFL ablation and 124 (age, 61±11 years; 72% male; left ventricular ejection fraction, 59±7%) had AF ablation only. In group 2 (age, 62±9 years; 76% male; left ventricular ejection fraction, 58±10%), only AFL was ablated by achieving bidirectional isthmus conduction block. Baseline characteristics were not different across groups. At 21±9 months of follow-up, 117 in group 1 (64%) and 34 in group 2 (19%) were arrhythmia free ( P &lt;0.001). In group 1, scores on most quality-of-life subscales showed significant improvement at follow-up, whereas group 2 patients derived relatively minor benefit. Conclusions— In coexistent AF and AFL, lower recurrence rate and better quality of life are associated with AF ablation only or AF+AFL ablation than with lone AFL ablation. Furthermore, quality of life directly correlates with freedom from arrhythmia, as shown in this study for the first time in patients blinded to the procedure. Clinical Trial Registration— URL: http://www.clinicaltrial.gov/ . Unique identifier: NCT01439386.
WHICH MOLES MATTER? THE ASSOCIATION BETWEEN MELANOCYTIC NAEVI AND MALIGNANT MELANOMATA
Authors: Rona M. MacKie
Journal: British Journal of Dermatology (1981)

Journal Article WHICH MOLES MATTER? THE ASSOCIATION BETWEEN MELANOCYTIC NAEVI AND MALIGNANT MELANOMATA Get access Rona M. MacKie Rona M. MacKie Department of Dermatology, University of Glasgow Professor Rona M. MacKie, Department of Dermatology, University of Glasgow, Anderson College Building, 56 Dumbarton Road, Glasgow G11 6NU. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 105, Issue 5, 1 November 1981, Pages 607–609, https://doi.org/10.1111/j.1365-2133.1981.tb00809.x Published: 01 November 1981
Helminth-derived Products Inhibit the Development of Allergic Responses in Mice
Authors: Claudia M. Trujillo-Vargas, Melanie Werner-Klein, Gisela Wohlleben, Tobias Polte, Gesine Hansen, Stefan Ehlers, Klaus J. Erb
Journal: American Journal of Respiratory and Critical Care Medicine (2006)

Epidemiological studies suggest that infections with helminths protect from the development of asthma. Supporting this view is our published finding that infection with Nippostrongylus brasiliensis decreased ovalbumin-induced Th2 responses in the lung of mice.To evaluate if N. brasiliensis excretory-secretory products also prevent the development of asthma.Mice were immunized with ovalbumin/alum intraperitoneally in the absence or presence of helminthic products and then challenged intranasally with ovalbumin. Six days later, we analyzed if the mice developed Th2 responses in the lung.The application of the helminthic products together with ovalbumin/alum during the sensitization period totally inhibited the development of eosinophilia and goblet cell metaplasia in the airways and also strongly reduced the development of airway hyperreactivity. Allergen-specific IgG1 and IgE serum levels were also strongly reduced. These findings correlated with decreased levels of IL-4 and IL-5 in the airways in product-treated animals. The suppressive effects on the development of allergic responses were independent of the presence of Toll-like receptors 2 and 4, IFN-gamma, and most important, IL-10. Interestingly, suppression was still observed when the helminthic products were heated or treated with proteinase K. Paradoxically, we found that strong helminth product-specific Th2 responses were induced in parallel with the inhibition of ovalbumin-specific responses.Our results suggest that helminths suppress the development of asthma by secreting substances that modulate allergic responses without affecting the generation of helminth-specific Th2 immunity. The identification of these products may lead to the design of novel therapeutic intervention strategies for the treatment of asthma.
Public health researchers engage with media for greater good, not to boost their egos, finds study
Authors: M. Sweet
Journal: BMJ (2012)

Influential public health researchers view working with the media as an important part of their jobs, finds a new study that challenges negative stereotypes about academics’ engagement with the media.

A study of 36 Australian public health researchers, nominated by peers as leaders in their fields, found that they saw working with the media as “a critical aspect of their professional duty to advance public health.”

The study, to be published in the Journal of Health Communication , was conducted by researchers from the University of Sydney and University of Queensland.1

Researchers interviewed for the study said that some colleagues regarded those with high media profiles with “disdain,” seeing media engagement as an unseemly “ego-driven, empire-building” activity favoured by self promoting “show ponies.”

However, all but one of the researchers in the study regularly engaged with the media …
More reasons to dread rain on vacation? Dengue fever in 42 German and United Kingdom Madeira tourists during autumn 2012
Authors: C Frank, M Höhle, K Stark, J Lawrence
Journal: Eurosurveillance (2013)

In October and November 2012 residents and tourists in the Autonomous Region of Madeira, Portugal, were affected by dengue fever. The outbreak waned during the unusually dry winter. Using a Monte Carlo test we investigated the hypothesis that rainy weather conveyed increased risk of dengue virus infection among tourists. Results confirmed the hypothesis. As it is unclear whether the outbreak is over, upkeep and emphasis on mosquito avoidance on rainy days may help residents and tourists reduce infection risk.
A conspiracy of anonymity
Authors: Des Spence
Journal: BMJ (2013)

“How do you think of something to write every week?” someone asks.

Someone helpfully replies for me: “He doesn’t. He just rearranges the same one.” 

Many a true word said in jest. But the themes of medicine are constant in time and geography. They are important but abstract, and completely ignored in medical education: doctoring is about reading people, knowing when to listen and act but also knowing when not to listen and not to act. At its core, doctoring is the willingness and …
Correction:Methods for Voluntary Weight Loss and Control
Authors: Millicent Higgins
Journal: Annals of Internal Medicine (1993)

Corrections15 November 1993Correction: Methods for Voluntary Weight Loss and ControlFREEMillicent Higgins, MD, Ralph D'Agostino, MD, William Kannel, MD, and Janet Cobb, MDMillicent Higgins, MDSearch for more papers by this author, Ralph D'Agostino, MDSearch for more papers by this author, William Kannel, MDSearch for more papers by this author, and Janet Cobb, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-10-199311150-00032 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Correction: Missing AuthorThe name of one author, Joan Pinsky, MA, was omitted from the author listing in the article referenced below.Reference1. Higgins M, D'Agostino R, Kannel W, Cobb J. Benefits and adverse effects of weight loss: observations from the Framingham Study. Ann Intern Med. 1993; 119(pt 2):758-63. Google Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1993Volume 119, Issue 10Page: 1055KeywordsWeight loss ePublished: 15 August 2000 Issue Published: 15 November 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Federal Agency Focuses on Outcomes Research
Authors: Charles Marwick
Journal: JAMA (1993)

FACED with an apparently insatiable and increasing demand for more medical services and the failure of several efforts to contain the costs involved, Congress in December 1989 created the Agency for Health Care Policy and Research and charged it with "systematically studying the relationships between health care and its outcomes." The underlying hope was to introduce some rational system for evaluating which procedures work and which do not in everyday medical practice. The final legislation and the impetus that brought the agency into being were the direct result of wide variations in medical practice, found by a number of researchers. The leader in drawing attention to these anomalies was John A. Wennberg, MD, Dartmouth Medical School, Hanover, NH. <h3>Wide Variation</h3> Wennberg documented wide variations in clinical practice in two of the nation's most medically sophisticated cities—Boston, Mass, and New Haven, Conn. Patients with angina pectoris in New Haven were more
Erythrocyte Destruction in Different Types of Starr-Edwards Aortic Ball Valves
Authors: ERIK MYHRE, JON DALE, KNUT RASMUSSEN
Journal: Circulation (1970)

Increased destruction of red blood cells follows the insertion of ball valves into the heart in most cases. Usually, hemolysis is slight, but in some patients uncompensated hemolytic anemia develops. To study the influence on hemolysis of the mechanical properties of the prostheses, the degree of erythrocyte destruction was evaluated in patients with Starr-Edwards aortic prostheses of different types and size. Fifty-six patients with Starr-Edwards aortic ball valves were examined; 13 had prostheses of the 1200 series with silastic rubber balls, and 43 had valves of the 2300 series with hollow Stellite (metallic) balls. Thirty-one patients had valves with an orifice area of 1.8 cm 2 or less; the others had larger-sized valves. The degree of hemolysis was predicted from the serum lactic dehydrogenase activity, which has previously been shown to correlate well with the red blood cell survival. The half-life of 51 Cr-labelled red cells was also determined in 16 cases. Hemolysis was significantly higher in patients with Stellite ball valves than in those with silastic rubber ball valves, and red blood cell destruction was more pronounced in patients with small prostheses than in patients with larger valves. Hemolysis was not higher in three patients with paravalvular leakage than in patients with competent prostheses. Valve type and size seem to be the most important factors in producing hemolysis.
Truncus arteriosus with single pulmonary artery: Influence of pulmonary vascular obstructive disease on early and late operative results
Authors: Derek A. Fyfe, David J. Driscoll, Roberto M. Di Donato, Francisco J. Puga, Gordon K. Danielson, Dwight C. McGoon, Douglas D. Mair
Journal: Journal of the American College of Cardiology (1985)
Cardiac Auscultation: Including Audio-Visual Principles
Authors: L. E. January
Journal: JAMA (1961)

A renaissance in cardiac auscultation has occurred during the past few years, proceeding hand in hand with the development of superior equipment for investigation and perfection of techniques to help with the definitive diagnosis of acquired and congenital cardiac defects. As a result, there is more valid information available today about the normal and abnormal sounds and noises associated with the action of the heart and the flow of blood than at any other period in history. The second edition of this small book has kept pace with these developments. This edition, like the first one, is dedicated to teaching clinical auscultation by the audio-visual method. Those persons who have used the equipment described by the authors as a teaching aid can testify to the success of this approach. This is a practical book, and it has a fresh approach to an important aspect of physical diagnosis. The stethograms in
Effect of age on fixed and labile components of airways resistance in asthma
Authors: M. I. Blackhall
Journal: Thorax (1971)

The lability index has been used to classify asthmatic subjects into three physiologically distinct groups and provide indices of the fixed and labile components of airways resistance. This classification was used to examine two series of asthmatics (A and B) in order to determine the effect of age on bronchial lability. The mean follow-up period was five years in series A and 18 years in series B. In series A the lability index had been measured previously and changes in value over a period of years were observed. Series B had been carefully assessed on clinical grounds in childhood, and from the case histories obtained then it was possible to determine the severity of the original symptoms and to compare them with the situation at follow-up when the lability index was measured. Results show that the labile component decreases with age but remains persistently abnormal in some subjects despite the absence of symptoms of asthma. The fixed component remains or increases with age. Thus highly labile asthmatic subjects (called group 2) have the best chance of improvement, while those subjects in whom the fixed component of airways resistance predominates (called group 3) are likely to remain in this group and have persistent symptoms.
Effect of integrated care for sick listed patients with chronic low back pain: economic evaluation alongside a randomised controlled trial
Authors: L. C. Lambeek, J. E. Bosmans, B. J. Van Royen, M. W. Van Tulder, W. Van Mechelen, J. R. Anema
Journal: BMJ (2010)

<b>Objective</b> To evaluate the cost effectiveness, cost utility, and cost-benefit of an integrated care programme compared with usual care for sick listed patients with chronic low back pain. <b>Design</b> Economic evaluation alongside a randomised controlled trial with 12 months’ follow-up. <b>Setting </b>Primary care (10 physiotherapy practices, one occupational health service, one occupational therapy practice) and secondary care (five hospitals) in the Netherlands, 2005-9. <b>Participants</b> 134 adults aged 18-65 sick listed because of chronic low back pain: 66 were randomised to integrated care and 68 to usual care. <b>Interventions</b> Integrated care consisted of a workplace intervention based on participatory ergonomics, with involvement of a supervisor, and a graded activity programme based on cognitive behavioural principles. Usual care was provided by general practitioners and occupational physicians according to Dutch guidelines. <b>Main outcome measures</b> The primary outcome was duration until sustainable return to work. The secondary outcome was quality adjusted life years (QALYs), measured using EuroQol. <b>Results</b> Total costs in the integrated care group (£13 165, SD £13 600) were significantly lower than in the usual care group (£18 475, SD £13 616). Cost effectiveness planes and acceptability curves showed that integrated care was cost effective compared with usual care for return to work and QALYs gained. The cost-benefit analyses showed that every £1 invested in integrated care would return an estimated £26. The net societal benefit of integrated care compared with usual care was £5744. <b>Conclusions</b> Implementation of an integrated care programme for patients sick listed with chronic low back pain has a large potential to significantly reduce societal costs, increase effectiveness of care, improve quality of life, and improve function on a broad scale. Integrated care therefore has large gains for patients and society as well as for employers.
Frequency and determinants of silent plaque disruption in patients with stable coronary syndrome
Authors: Yaqing Sun, Shumei Ma, Kyoichi Mizuno, Masamichi Takano, Kouji Seimiya, Kentaro Okamatsu, Hiroyuki Kamon, Ryota Uemura, Fumiyuki Ishibashi, Shinya Yokoyama, Takayoshi Ohba
Journal: Journal of the American College of Cardiology (2002)