tbuckley/cabot-search huggingface dataset:
Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen
Authors: Charles G. Drake, Amy D.H. Doody, Marianne A. Mihalyo, Ching-Tai Huang, Erin Kelleher, Sowmya Ravi, Edward L. Hipkiss, Dallas B. Flies, Eugene P. Kennedy, Meixiao Long, Patrick W. McGary, Lee Coryell, William G. Nelson, Drew M. Pardoll, Adam J. Adler
Journal: Cancer Cell (2005)
P85 Assessing the Patient Experience of COPD Care Using an Ipsos MORI Questionnaire as a Patient Reported Experience Measure (PREM): Abstract P85 Table 1
Authors: DJ Powrie, M Ali, S Ansari, KG Lingam, P Mulley, S Hope, AG Davison
Journal: Thorax (2012)

<h3>Patient</h3> reported experience measures provide vital information on the experience that patients have regarding their care and thus have become a recent focus of interest. We have developed a questionnaire to assess PREMS in patients with COPD attending a hospital outpatient clinic. The purpose of the questionnaire was to assess whether the processes that are necessary to improve outcomes in COPD had been dealt with in the clinic and understood by the patient. Also to assess in a similar way the understanding of COPD by the patient and whether they were satisfied with the consultation. <h3>Results</h3> The questionnaire was completed by 142 new and follow up patients. Results are presented in the table below. 92% of patients had spirometry performed at their visit and 78% had the results explained. Before the consultation 57% of patients thought they had a good understanding, 30% moderate and 13% little or no understanding of their condition. Afterwards these improved to 67%,23% and 10% respectively. 29% believed that their knowledge of how to reduce exacerbations had increased after the consultation. 87% of patients thought that the length of the review was about right (average 20 minutes). 85% were satisfied overall with the consultation. <h3>Conclusion</h3> We have studied COPD care from the patient’s perspective. We have found evidence that simple clinician-led measures (such as flu vaccination and spirometry) have been explained either in clinic or previously and understood by the patient. We were less successful in dealing with more complex patient-centred experiences such as understanding of the disease and self management of exacerbations. Following this study we plan to develop a questionnaire dealing with the patient’s understanding of their disease that would be filled in before attending clinic. This would allow areas of concern to the patient to be specifically addressed in the consultation. In addition the questionnaire could be used to provide feedback to individual clinicians on their effectiveness in outpatient clinics.
Familial Occurrence of Persistent Mullerian Structures in Otherwise Normal Males
Authors: C. G. D. Brook, H. Wagner, M. Zachmann, A. Prader, S. Armendares, S. Frenk, P. Aleman, S. S. Najjar, M. S. Slim, N. Genton, C. Bozic
Journal: BMJ (1973)

Eight cases of males with persistent Müllerian structures are reported in four pairs of unrelated siblings. A genetically inherited failure to produce or to respond to the Müllerian-inhibiting substance elaborated by the fetal testis is postulated.
Specificity and regulation of a synaptic vesicle docking complex
Authors: Jonathan Pevsner, Shu-Chan Hsu, Janice E.A. Braun, Nicole Calakos, Anthony E. Ting, Mark K. Bennett, Richard H. Scheller
Journal: Neuron (1994)

Synaptic vesicles are proposed to dock at the presynaptic plasma membrane through the interaction of two integral membrane proteins of synaptic vesicles, VAMP and synaptotagmin, and two plasma membrane proteins, syntaxin and SNAP-25. We have characterized the binding properties of these proteins and observed SNAP-25 potentiation of VAMP 2 binding to syntaxins la and 4 but not syntaxins 2 or 3. n-sec1, a neuron-specific syntaxin-binding protein, bound syntaxin with nanomolar affinity, forming a complex that is distinct from the previously identified 7S and 20S syntaxin-containing complexes. This suggests that syntaxin exists in at least three states: bound to n-sec1, in a 7S particle, and in a 20S particle. Recombinant n-secl inhibited VAMP or SNAP-25 binding to syntaxin. We propose that the specific associations of VAMP, SNAP-25, and syntaxin mediate vesicle docking and that a syntaxin/n-sec1 complex precedes and/or regulates formation of these complexes.
1165-107 Measurement versus calculation of training heart rate in patients with coronary artery disease treated by beta-blockers
Authors: Philippe Meurin, Ahmed Bendriss, Helene Weber, Gabriel Thabut, Benedicte Zamblera, Dominique Odjinkem, Nathalie Renaud, Jean Yves Tabet
Journal: Journal of the American College of Cardiology (2004)
THE USE OF ETHER IN PERTUSSIS BY INTRAMUSCULAR AND RECTAL INJECTION
Authors: ALTON GOLDBLOOM
Journal: JAMA (1925)

The use of ether by intramuscular injection was first suggested by Audrain<sup>1</sup>in 1914. Besides advocating its use in pertussis, he was no less enthusiastic concerning its efficacy in infections, such as scarlet fever, measles and bronchopneumonia. He believed, in the case of pertussis, that it exerted a specific bactericidal effect on the Bordet-Gengou bacillus. In the last five years, an increasing number of writers have almost unanimously testified to the usefulness of ether in pertussis, their degree of enthusiasm varying from that of Castorina,<sup>2</sup>who feels that the problem of the treatment of whooping cough is now on the road to a definite solution, and that "results obtained with vaccinotherapy and intramuscular injection of ether lead us to hope that we are at last in possession of an efficacious means of combating this serious disease," to the more conservative conclusions of Macciotta,<sup>3</sup>who feels that ether
Abstract 4093: Investigating a role for menin and MLL-AF9 in suppressing C/EBPβ-mediated mixed lineage leukemia cell differentiation
Authors: Austin T. Thiel, Xianxin Hua
Journal: Cancer Research (2012)

Abstract The Mixed Lineage Leukemia (MLL) gene forms chromosomal translocations with one of multiple partner genes, leading to the expression of MLL fusion proteins (MLL-FPs), which cause acute leukemias with particularly poor prognoses. MLL-FPs contain an N-terminal portion the MLL protein, which is responsible for MLL-FP recruitment to MLL target genes, through interactions with various proteins, including the MEN1 gene product menin. The ability of menin to recruit MLL-FPs to target genes is critical for leukemic transformation. A central hallmark of leukemia is oncogene-mediated suppression of differentiation. Many leukemic oncogenes, including Bcr-Abl and AML-ETO suppress differentiation through inhibiting the C/EBPα transcription factor, a driver of myeloid differentiation. However, a mechanism for MLL-FP-mediated inhibition of C/EBPα has not been reported. We have found that disruption of the MLL-AF9 pathway by acute depletion of its recruiting factor menin causes differentiation of MLL-AF9 leukemia cells in vivo. These results suggest that a major function of menin/MLL-AF9 is to maintain leukemia cells in a de-differentiated state. Further, cDNA microarray analysis of primary MLL-AF9 splenocytes with acute menin depletion showed induction of genes involved in hematopoietic differentiation, including transcriptional targets of C/EBPβ. These results suggest a mechanism for MLL-FP-mediated inhibition of C/EBPα and suppression of leukemic progenitor cell differentiation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4093. doi:1538-7445.AM2012-4093
573 HEPATIC ENCEPHALOPATHY IS ASSOCIATED WITH IMPAIRED BRAIN OXYGEN METABOLISM AND BLOOD FLOW, NOT INCREASED AMMONIA UPTAKE
Authors: G. Dam, S. Keiding, O.L. Münk, P. Ott, H. Vilstrup, L.K. Bak, H.S. Waagepetersen, A. Schousboe, M. Sørensen
Journal: Journal of Hepatology (2012)
Treatment of severe side effects after vagotomy and gastroenterostomy by closure of gastroenterostomy without pyloroplasty.
Authors: M J McMahon, D Johnston, G L Hill, J C Goligher
Journal: BMJ (1978)

We describe nine patients who had severe, persistent abdominal pain, vomiting, dumping, or diarrhoea several years after truncal vagotomy and gastroenterostomy had been performed for duodenal ulceration. Each patient was judged to have a bad clinical result (Visick grade 4). There was no evidence of recurrent ulceration in any of the patients, and in each the patency of the pyloric canal was confirmed radiologically or endoscopically. Each patient was treated by simply dismantling the gastroenterostomy without addition for a pyloroplasty. In one patient the surgeon suspected that a vagal trunk might have been left intact, and a revagotomy was performed by the "highly selective" technique. Postoperatively, none of the patients developed gastric retention. Symptomatic improvement occurred in eight patients, and four of them achieved perfect results (Visick grade 1). Side effects are common after vagotomy and gastroenterostomy, and are largely attributable to the presence of the gastroenterostomy stoma. Our results show that the symptoms may be alleviated by closing the gastroenterostomy, without precipitating gastric retention.
Reviews and Notes: Policy: Bringing the Hospital Home: Ethical and Social Implications of High-Tech Home Care
Authors: Karen Buhler-Wilkerson
Journal: Annals of Internal Medicine (1996)

Literature of Medicine15 October 1996Reviews and Notes: Policy: Bringing the Hospital Home: Ethical and Social Implications of High-Tech Home CareKaren Buhler-Wilkerson, RN, PhDKaren Buhler-Wilkerson, RN, PhDUniversity of Pennsylvania, Philadelphia, PA 19104Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-8-199610150-00037 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail JD Arras; ed. 259 pages. Baltimore: Johns Hopkins Univ Pr; 1995. $40.00. ISBN 0-8018-4990-X. Order phone 800-537-5487.It is expected, when the figures are available, that expenditures for home care in the United States in 1995 will be shown to have exceeded $27 billion. With 17 000 agencies delivering services to approximately 7 million persons, home care is the fastest growing segment of the health services industry. Bring the Hospital Home examines the newest aspect of this expansion: the frenetic transfer of technology to the home. This change has created substantial gaps between technical prowess and discernment of the humane, ... Author, Article, and Disclosure InformationAffiliations: University of Pennsylvania, Philadelphia, PA 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1996Volume 125, Issue 8Page: 703KeywordsChildrenDistillationElderlyFoodHIVMedical dialysisMedical servicesPediatric infectionsPublic policyVentilators ePublished: 15 August 2000 Issue Published: 15 October 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Congestive Heart Failure Model of Schizophrenia
Authors: Earl A. Burch
Journal: JAMA (1979)

Many primary care physicians wish to address the psychiatric aspects of their medically ill patients but are impatient with the abstract terminology used in psychiatry's past psychoanalytical period. Modern psychiatry is a more integrated field and considers the biological and social as well as the analytical contributors to disease. Using these newer concepts, we present a teaching model in which schizophrenia is viewed as a syndrome and is compared with the well-known medical syndrome of congestive heart failure. This approach facilitates the conceptualization of a complex psychiatric illness and makes it more appealing to primary care physicians by demonstrating common gound between medicine and psychiatry.
Antibiotic Mixtures
Authors: Robert O. Levitt, Ralph H. Hubble, Dayle Snyder, Olga Miloradovitch
Journal: New England Journal of Medicine (1957)

FOR several years, clinical investigators have been intrigued with the possibility of combining antibiotic drugs to enhance their therapeutic effects. It has been asserted that antibiotic mixtures should be used for their synergistic activity, to prevent the emergence of resistant micro-organisms and to increase the safety and tolerance of the drugs used. That these effects have been observed in isolated cases is well known. Recently, a new antibiotic combination has appeared for which the claim of synergism has been made. The present report deals with the inability to demonstrate, in vitro, the claim of synergism advanced for this combination, tetracycline . . .
Cardiac arrest with clomipramine.
Authors: G Singh
Journal: BMJ (1972)

sH mEDICAL jouRNAL 16 smm 1972 interpret.Ultrasound detects bowel move--ment because the bowel wall in peristalsis presents a moving iterface which "modu- lates" the beam of ulrasond, which is then converted to sound.The results are qualitative but they provide the important information on whether bowel activity is present.The technique is easily applicable to con- valescent patients, is simple to interpret, and in this series provided reliable and useful information.Ultrasound can be a useful additional tool in the assessment of the silent abdomen.-Iam, etc.,
Guidelines for medical audit: seven principles.
Authors: C. D. Shaw, D. W. Costain
Journal: BMJ (1989)

The government, general managers, and professional bodies all agree that medical audit should be implemented throughout the United Kingdom. Nevertheless, it is not yet decided either nationally or locally how audit should be defined and what its implications will be. In an analysis to find ways of measuring the design and effectiveness of hospital audit, therefore, seven main measures emerged that might serve as practical criteria. These were the definition of medical and managerial responsibilities; medical organisation; scope of audit; essential characteristics; resources needed; record keeping; and evaluation. Though generally consistent with the proposals of the government and the Department of Health, these seven principles offer some alternative approaches.
Abstract 479: A novel dynamic delivery system enabling high efficiency transfection of cells
Authors: James Ludtke, Anthony Lauer, Austin Storck, Nicholas Rossi, Karen Neder, Anatoly Pinchuk, Laura Juckem
Journal: Cancer Research (2014)

Abstract Transfection is an enabling technique for cellular and molecular biologists to study expression and knockdown of gene expression. Over the past decade, many researchers have utilized liposomal systems to deliver nucleic acids; however, this method has many caveats including low transfection efficiency and high cellular toxicity in some cell types. To address these shortcomings, Mirus Bio has developed a novel non-liposomal technology called the TransIT-X2™ Dynamic Delivery System. This unique polymeric delivery system is able to effectively condense negatively charged nucleic acids (plasmid DNA and/or siRNA), enter cells and break out of the endosomal compartment, a critical barrier for transfection. The plasmid and siRNA can then be delivered to their respective functional locations, the nucleus and the cytoplasm. In this study, we demonstrate functional transfection of labeled plasmid DNA co-delivered with labeled siRNA illustrating the dual abilities of the TransIT-X2 Dynamic Delivery System. Additionally, extensive head-to-head comparisons with a popular liposomal reagent, Lipofectamine® 2000 were performed using a luciferase expression assay in 30 cell types; TransIT-X2 demonstrated superior performance in 20 cell types with 11 showing greater than 2-fold higher expression compared to Lipofectamine 2000. Transfection efficiency of green fluorescent protein (GFP) was measured using flow cytometry and visualized by microscopy; most cell types had greater than 50% GFP efficiency. Lastly, gene knockdown after delivery of siRNA or miRNA was assessed. Two endogenous genes, GAPDH and AHA1, were targeted for siRNA knockdown and mRNA levels were assessed by qRT-PCR. miRNA function was assessed by the decrease in the miR-1 target mRNA PTK9. The TransIT-X2 Dynamic Delivery System shows effective knockdown via siRNA or miRNA. The TransIT-X2 Dynamic Delivery System offers researchers exceptional broad-spectrum transfection of plasmid DNA and siRNA. This cutting edge, non-liposomal polymeric delivery method enhances endocytic release of the transfection complexes allowing researchers to obtain very high transfection efficiencies. Citation Format: James Ludtke, Anthony Lauer, Austin Storck, Nicholas Rossi, Karen Neder, Anatoly Pinchuk, Laura Juckem. A novel dynamic delivery system enabling high efficiency transfection of cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 479. doi:10.1158/1538-7445.AM2014-479
The cardiocardiac sympathetic reflex during coronary occlusion in anesthetized dogs.
Authors: R B Felder, M D Thames
Journal: Circulation Research (1981)

Cardiac sympathetic afferent fibers activated during coronary occlusion exert an excitatory influence on sympathetic discharge to the heart in cats after spinal cord section. The significance of this cardiocardiac sympathetic reflex response during myocardial ischemia in animals with an intact neuraxis is unknown. We studied the responses of efferent cardiac sympathetic nerve activity (CSNA), arterial pressure, and heart rate to coronary occlusion in two groups of dogs with cardiac sympathetic reflexes intact and with other reflex inputs affecting CSNA sectioned or controlled. In group I (n = 10), the vagi were sectioned, the spinal cord remained intact, and the carotid sinuses were isolated and perfused to maintain baroreceptor input constant. Coronary occlusion was performed at moderate and low basal levels of CSNA by setting carotid sinus pressure at 125-150 and 200 mm Hg, respectively. Under these conditions, CSNA was not altered by occlusion of either the anterior descending or the circumflex coronary artery. In group II (n = 4), the vagi were sectioned and the spinal cord was interrupted. In these dogs, CSNA increased significantly (61 +/- 19%) during coronary occlusion. These results show that an excitatory cardiocardiac sympathetic reflex can be demonstrated in dogs with spinal cords sectioned but not with spinal cords intact. This finding is consistent with the view that inhibitory bulbospinal pathways minimize the influence of the spinal cardiocardiac sympathetic reflex during myocardial ischemia in anesthetized dogs.
The psychosocial impact of bilateral prophylactic mastectomy: prospective study using questionnaires and semistructured
Authors: M. B. Hatcher
Journal: BMJ (2001)

<h3>Abstract</h3> <b>Objectives:</b> To investigate the psychosocial impact of bilateral prophylactic mastectomy for women with increased risk of breast cancer and to identify, preoperatively, risk factors for postoperative distress. <b>Design:</b> Prospective study using interviews and questionnaire assessments. <b>Setting:</b> Participants9 homes throughout the United Kingdom. <b>Participants:</b> 143 women with increased risk of developing breast cancer who were offered bilateral prophylactic mastectomy and who accepted or declined the surgery; a further 11 were offered surgery but deferred making a decision. <b>Main outcome measures:</b> Psychological and sexual morbidity. <b>Results:</b> Psychological morbidity decreased significantly over time for the 79 women who chose to have surgery (accepters): 58% (41/71) preoperatively <i>v</i> 41% (29/71) 6 months postoperatively (difference in percentages 17%, 95% confidence interval 2% to 32%; P=0.04) and 60% (39/65) preoperatively <i>v</i> 29% (19/65) 18 months postoperatively (31%, 15% to 47%; P&lt;0.001). Psychological morbidity in the 64 women who declined surgery (decliners) did not decrease significantly: 57% (31/54) at baseline <i>v</i> 43% (23/54) at 6 months (14%, 0% to 29%; P=0.08) and 57% (29/52) at baseline <i>v</i> 41% (21/52) at 18 months (16%;—2% to 33%; P=0.11). Greater than normal proneness to anxiety was more common in the decliners than in the accepters: 78% (45/58) <i>v</i> 56% (41/73) (22%, 6% to 38%; P=0.006). Accepters were more likely than decliners to believe it inevitable that they would develop breast cancer (32% (24/74) <i>v</i> 10% (6/58) (difference in percentages 22%, 9% to 35%; P=0.003)), and decliners were more likely to believe that screening could help (92% (55/60) <i>v</i> 74% (55/74) (18%, 5% to 31%; P=0.007)). Level of sexual discomfort and degree of sexual pleasure did not change significantly over time in either of the two groups. <b>Conclusions:</b> Bilateral prophylactic mastectomy may provide psychological benefits in women with a high risk of developing breast cancer.
Emotions and emotion cognition contribute to the construction and understanding of mind
Authors: Carroll E. Izard
Journal: Behavioral and Brain Sciences (2004)

Carpendale &amp; Lewis's (C&amp;L's) interesting and insightful article did not integrate several potentially useful notions from emotion theory and research into their explanatory framework. I propose that emotions are indigenous elements of mind and that children's understanding of them is fundamental to their understanding of the mental life of self and others, understandings critical to the development of social and emotional competence.
Screening for type 2 diabetes in primary care
Authors: P. E H Schwarz, J. Li, S. R Bornstein
Journal: BMJ (2009)

The QDScore is a useful computer based screening tool 

In the linked study (doi:10.1136/bmj.b880), Hippisley-Cox and colleagues present a new score that was developed and validated in a large prospective cohort to estimate the risk of acquiring type 2 diabetes over a 10 year period. This score is unique in that it considers social deprivation and ethnicity in a standardised algorithm.1 The advantage of the QDScore is that it systematically uses electronically recorded medical data available in clinical practice. The algorithm does not require laboratory tests and can be used in clinical settings and for self assessment.

Several risk prediction tools based on the risk factors for type 2 diabetes have been developed.2 Measures of performance of a screening tool should consider …
The Etiology of Diverticula of the Intestine
Authors: R. Davies-Colley
Journal: BMJ (1926)

DIVERTICULA OF THE INTESTINE.[ THt BRITISH -~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ã nd normal saline into the bronchi.In the next year they also published an analysis of cases.ofpulmonary abscesses; including those which were complicated with bronchitis.Ewart Martin (Edinburgh), in 1824, published his ex- periences of bronchoscopy in relation to lung diseases, and gave results of treatment, some cases lhaving extended over one and a half years.Howarth, in 1925, published, in association with Cassidy, a case of abscess of the lung and bronchiectasis treated by bronchoscopic aspiration and lavage.
Zoon's balanitis (balanitis circumscripta plasmacellularis)
Authors: P. SOUTEYRAND, E. WONG, D.M. MACDONALD
Journal: British Journal of Dermatology (1981)

The clinical and histopathological features of nineteen cases of Zoon's balanitis and a comparable lesion of the vulva have been reviewed. The condition is particularly distinguished by characteristic histological changes affecting the epidermis and the dermal vasculaturc. The presence of a plasma cell infiltrate is relatively non-specific. Recognition of these features should allow simple differentation from premalignant, infective and other inflammatory penile lesions which may be more responsive to treatment.