IgA Myeloma Globulin and Bence Jones Proteinuria in Diffuse Plasmacytoma of Small Intestine
Authors: Y. Tangun, Z. Saracbasi, S. Inceman, F. Danon, M. Seligmann
Journal: Annals of Internal Medicine (1975)

Letters1 November 1975IgA Myeloma Globulin and Bence Jones Proteinuria in Diffuse Plasmacytoma of Small IntestineY. TANGUN, Z. SARACBASI, S. INCEMAN, F. DANON, M. SELIGMANNY. TANGUNSearch for more papers by this author, Z. SARACBASISearch for more papers by this author, S. INCEMANSearch for more papers by this author, F. DANONSearch for more papers by this author, M. SELIGMANNSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-5-673_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhether single or multiple, primary plasmacytomas of the small intestine are usually nodular and circumscribed tumors (1, 2), whereas alpha chain disease is usually characterized by a diffuse plasma cell proliferation of the whole length of the small intestine and of mesenteric lymph nodes (3, 4). This disease affects young patients of particular geographic origin and may include most cases of so-called "Mediterranean-type" of abdominal lymphoma with malabsorption (5). We have studied a Turkish patient with clinicopathologic features analogous to those of alpha chain disease. We found in him a true IgA myeloma globulin and Bence Jones protein.A 40-year-old...References1. GOLDSTEINPOKER WN: Multiple myeloma involving the gastrointestinal tract. Gastroenterology 51:87-93, 1966 CrossrefMedlineGoogle Scholar2. DOUGLASSSIKALEVEEN HJH: Plasmacytoma: a not so rare tumor of the small intestine. Cancer 28:456-460, 1971 CrossrefMedlineGoogle Scholar3. SELIGMANNDANONHUREZ MFD: Alpha chain disease: a new immunoglobulin abnormality. Science 162:1396-1397, 1968 CrossrefMedlineGoogle Scholar4. RAMBAUDBOGNELPROST JCA: Clinico-pathological study of a patient with "Mediterranean" type of abdominal lymphoma and a new type of IgA abnormality ("alpha chain disease"). Digestion 1:321-336, 1968 CrossrefMedlineGoogle Scholar5. SELIGMANN M: The main immunochemical, clinical and pathological features of alpha chain disease. Arch Intern Med 135: 78-82, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHeavy-Chain DiseaseImmunobiology and Pathogenesis of Alpha Chain DiseaseImmunoproliferative small intestinal disease in Greece: presentation of 13 cases including two from Albaniaα-Heavy Chain Disease, Mediterranean Lymphoma, and Immunoproliferative Small Intestinal DiseaseAlpha Chain Disease and Related Lymphoproliferative DisordersAlpha-Heavy Chain DiseaseB-Lymphoproliferative disorders: A Proposed unified pathogenetic pathwayIntestinal Immunity and MalabsorptionAlpha-chain disease without qualitative serum IgA abnormality: Report of two cases, including a “nonsecretory” formGastrointestinal involvement with myelomaGamma heavy chain disease simulating alpha chain disease.α–Chain Disease: A Possible Model for the Pathogenesis of Human LymphomasThe Digestive Form of α-Chain DiseaseIgG myeloma presenting as ulcerative colitis.Pathological study of alpha-chain disease, with special emphasis on evolutionAsynchronous development of two monoclonal proteins (igm λ and γ1 chains) in a patient with abdominal lymphomaAlpha-Chain Disease 1 November 1975Volume 83, Issue 5Page: 673-673KeywordsCell proliferationGlobulinsLymph nodesLymphomaMyelomaPlasma cellsProteinsProteinuriaSmall intestine Issue Published: 1 November 1975 PDF DownloadLoading ...