tbuckley/cabot-search huggingface dataset:
PRECIPITATING ANTIBODIES AGAINST <i>MICROPOLYSPORA PHAENI</i> IN SERA FROM MUSHROOM WORKERS
Authors: BIRGER BROCH MØLLER, POUL HALBERG, SUSANNE GRAVESEN &, BENT WEEKE
Journal: Allergy (1976)

A new method for determining precipitating antibodies in allergic alveolitis is presented. The principle used is immunoelectrophoresis, either as a counterelectrophoresis or as a crossed immunoelectrophoresis with intermediate gel. Twenty-two mushroom workers without anamnestic signs of allergic alveolitis and 15 control persons were investigated. Twelve mushroom workers (55%) had precipitating antibodies as determined by crossed immunoelectrophoresis, and nine of these persons had antibodies demonstrated with counterelectrophoresis. Thus, the sensitivity seems greater in the crossed immunoelectrophoresis, but we find that the simpler counterelectrophoresis is an excellent screening procedure in patients suspected of allergic alveolitis. In the controls only one person had precipitating antibodies, though the antigen tested for Micropolyspora phaeni exists ubiquitously. It seems probable from this study that the antigenic load is important, although it is remarkable that no mushroom worker with precipitating antibodies against M. phaeni had ever experienced symptoms compatible with allergic alveolitis.
Glucosuria in Children with Diabetes: Advantages of the 2-Drop Clinitest Method
Authors: Robert J Winter, Howard S Traisman, Orville C Green
Journal: Diabetes Care (1979)

In order to assess the actual and theoretical limitations of using the traditional urinary glucose determinations as an indicator of plasma glucose concentration, we have measured plasma and urine glucose concentrations in 37 children with diabetes mellitus. A constant blood withdrawal system enabled an accurate estimate of the glucose concentration presented to the renal glomerulus over the 30-min period of blood collection and urine formation. The theoretical range of plasma glucose over which the 5-Drop and 2-Drop Clinitest methods are sensitive is 32 mg/dl and 81 mg/dl, respectively. This suggests that the 2-Drop method is the procedure of chioce for most insulin-dependent diabetic patients. Nevertheless, the extremely wide range of plasma glucose corresponding to a given urinary glucose measurement limits the precision with which any single urine test can be interpreted.
F3 peptide-functionalized PEG-PLA nanoparticles co-administrated with tLyp-1 peptide for anti-glioma drug delivery
Authors: Quanyin Hu, Guangzhi Gu, Zhongyang Liu, Mengyin Jiang, Ting Kang, Deyu Miao, Yifan Tu, Zhiqing Pang, Qingxiang Song, Lei Yao, Huimin Xia, Hongzhan Chen, Xinguo Jiang, Xiaoling Gao, Jun Chen
Journal: Biomaterials (2012)
Comparison of the Incidence and Pattern of Interstitial Lung Disease During Erlotinib and Gefitinib Treatment in Japanese Patients with Non-small Cell Lung Cancer: The Okayama Lung Cancer Study Group Experience
Authors: Katsuyuki Hotta, Katsuyuki Kiura, Nagio Takigawa, Hiroshige Yoshioka, Shingo Harita, Shoichi Kuyama, Toshiro Yonei, Keiichi Fujiwara, Tadashi Maeda, Keisuke Aoe, Hiroshi Ueoka, Haruhito Kamei, Shigeki Umemura, Tomonori Moritaka, Yoshihiko Segawa, Haruyuki Kawai, Akihiro Bessho, Katsuya Kato, Masahiro Tabata, Mitsune Tanimoto
Journal: Journal of Thoracic Oncology (2010)
1101 LENTIVIRAL VECTOR-MEDIATED PURIFICATION OF HEPATIC PROGENITORS DIFFERENTIATED FROM HUMAN EMBRYONIC STEM CELLS
Authors: G. Yang, T. Touboul, S. Corbineau, C. Martinet, K. Si-Tayeb, D. Clay, R. Gayon, S. Goulinet-Mainot, L. Vallier, P. Bouillé, A. Dubart-Kupperschmitt, A. Weber
Journal: Journal of Hepatology (2011)
X-ray negative dyspepsia.
Authors: R H Salter
Journal: BMJ (1977)

were carried out: clinical assessment by a cardiologist4 blind to the treatment, a 12-lead ECG, serum creatinine and electrolyte concentrations, and routine liver function tests.There was no significant change in any of these during the study (paired Student's t tests in the case of parametric and Z2 tests with Yates's correction or Fisher's exact test for non-parametric data).Venous blood samples for digoxin assay (3-Lanoxitest) were collected just before the dose, one during the third week and a second during the fourth on each formulation.Since there was no significant difference in concentration be- tween weeks on either formulation (paired t tests, P>02) steady state con- ditions may be assumed.0.5 Tablets 0-4 - 0-3 .~~Calculated dose (mg) 02 - 0.
Diagnosis of Gallbladder Dyskinesia by Quantitative Hepatobiliary Scintigraphy
Authors: Attila Szepes, Vikt??ria Bertalan, Tam??s V??rkonyi, L??szl?? P??vics, J??nos Lonovics, L??szl?? Mad??csy
Journal: Clinical Nuclear Medicine (2005)

Aim: The aim of the present study was to develop a new pharmacologic method during hepatobiliary scintigraphy by which patients with functional and organic forms of gallbladder (GB) dysfunction can be differentiated. Methods: Quantitative hepatobiliary scintigraphy (QHBS) was performed on 31 patients with impaired GB motility selected by cerulein-augmented ultrasonography. Nineteen patients had acalculous biliary pain (ABP) and suspected GB dyskinesia, 6 patients had celiac disease, and 6 patients had type II diabetes mellitus. Sixty minutes after the isotope administration, 1 ng/bwkg/min cerulein (CCK10) was infused for 10 minutes, and then from the 90th minute, an equivalent dose of CCK10 was infused in the presence of 0.5 mg sublingual glyceryl trinitrate (GTN) in 12 or placebo in 7 consecutive patients. The GB ejection fraction (GBEF) was calculated repeatedly in time periods from 60 to 90 and from 90 to 120 minutes. Results: In the majority of patients with ABP and suspected GB dyskinesia, CCK10 and GTN coadministration normalized the previously impaired GB-emptying. When the cumulative results of all 12 patients were calculated, we demonstrated significant differences (P = 0.003) in the GBEF between the first (CCK10) versus the second (CCK10 plus GTN) stimuli: 19 ± 11% versus 40 ± 17%, respectively. In contrast, in 12 patients with celiac sprue and diabetes mellitus, no differences in the GBEF were detected when the first (CCK10 alone) versus the second (CCK10 plus GTN) stimuli was compared: 21 ± 10% versus 22 ± 13%, respectively. Finally, placebo and CCK10 coadministration in 7 consecutive patients with ABP and suspected GB dyskinesia did not influence the GBEF as compared with CCK10 alone: 13 ± 9% versus 15 ± 10%, respectively. Conclusion: GTN and CCK10 coadministration induces a significant improvement of the GBEF in patients with GB dyskinesia. The application of this new pharmacologic test during QHBS permitted the noninvasive separation of those patients with secondary impaired GB-emptying as a result of GB dyskinesia from those with primary forms of GB hypokinesia.
Blood Group Distributions
Authors: A. S. WIENER
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 July 1973Blood Group DistributionsA. S. WIENER, M.D.A. S. WIENER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-1-137_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The report of the NIH Conference in the February 1973 issue (pp. 259-269) repeats, on p. 261, a fallacy regarding studies on associations between blood groups and disease that has been encouraged by the myths in the Race-Sanger book. Significantly, this book is the only reference source cited by the authors, even though scores of books are now available; see, for example, the excellent section on blood groups that can readily be found in the new edition of J. B. Miale's book, Laboratory Medicine-Hematology, 1972.The fallacy in question, in its usual form, consists of determining the...References1. VOGELKRUGER FJ: Statistische Beziehungen zwischen den ABO-Blutgruppen und Krankheiten mit Ausnahme der Infektionskrankheiten. Blut 16:351-376, 1968 CrossrefMedlineGoogle Scholar2. WIENER A: Blood groups and disease. Am J Human Genet 22:476-483, 1970 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeisseria meningitidis, Neisseria lactamica and Moraxella catarrhalis share cross-reactive carbohydrate antigensZur Synthese von 4-Aminochinolinen durch intramolekulareFriedel?Crafts-Reaktion 1 July 1973Volume 79, Issue 1Page: 137-137KeywordsBlood groupsResearch laboratories ePublished: 1 December 2008 Issue Published: 1 July 1973 PDF downloadLoading ...
The plight of the student
Authors: C. D. Aring
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quantitative<i>In Vivo</i>Characterization of Intracellular and Extracellular pH Profiles in Heterogeneous Tumors: A Novel Method Enabling Multiparametric pH Analysis
Authors: Norbert W. Lutz, Yann Le Fur, Johanna Chiche, Jacques Pouysségur, Patrick J. Cozzone
Journal: Cancer Research (2013)

Acid production and transport are currently being studied to identify new targets for efficient cancer treatment, as subpopulations of tumor cells frequently escape conventional therapy owing to their particularly acidic tumor microenvironment. Heterogeneity in intracellular and extracellular tumor pH (pHi, pHe) has been reported, but none of the methods currently available for measuring tissue pH provides quantitative parameters characterizing pH distribution profiles in tissues. To this intent, we present here a multiparametric, noninvasive approach based on in vivo (31)P nuclear magnetic resonance (NMR) spectroscopy and its application to mouse tumor xenografts. First, localized (31)P NMR spectrum signals of pHi and pHe reporter molecules [inorganic phosphate (Pi) and 3-aminopropylphosphonate (3-APP), respectively] were transformed into pH curves using established algorithms. Although Pi is an endogenous compound, 3-APP had to be injected intraperitoneally. Then, we developed algorithms for the calculation of six to eight quantitative pH parameters from the digital points of each pH curve obtained. For this purpose, each pH distribution profile was approximated as a histogram, and intensities were corrected for the nonlinearity between chemical-shift and pH.
When Physicians Counsel About Stress: Results of a National Study
Authors: Aditi Nerurkar, Asaf Bitton, Roger B. Davis, Russell S. Phillips, Gloria Yeh
Journal: JAMA Internal Medicine (2012)

The prevalence of stress in primary care is high; 60–80% of visits may have a stress-related component.1 44% of Americans report an increase in psychological stress over the past five years.2 Stress is associated with more office visits and disease, but little is known about stress management counseling in primary care.3,4 Our study objective was to examine the rates of stress management counseling by U.S. primary care physicians and to identify associated factors.
Job and his "doctors": bedside wisdom in the book of Job
Authors: I. Kutz
Journal: BMJ (2000)

The book of Job has traditionally has been regarded as a philosophical or theological treatise on the nature of faith of a just man in an unjust world. Read by a modern clinician, the book becomes a treatise on adaptation to illness and loss, on doctor-patient relationships, and on the role of belief systems in the coping process.

#### Summary points

Viewed by a modern clinician, the book of Job unfolds as possibly the earliest description of patients and their healers struggling to cope with loss and illness

Job's lament contains all the recognised stages and elements of adaptation to calamity

Job's friends take on the role of healers, but, failing to recognise his needs, they blame their “patient” for his misfortunes and end up in a cycle of escalating empathic failure that renders them helpless

The failure experienced by Job's “healers” is not uncommon in modern doctors, who fail to recognise their own fear of helplessness and their own defensiveness

The assumed presence of a deity can provide coherence out of confusion for modern patients, believers and non-believers alike, and help them through the adaptation process, just as it did for Job

The book of Job, like an ancient mirror, reflects both the frail and heroic features of humans, which have changed little through the ages

Job is a thriving livestock rancher, married, and the father of 10 children. Renowned for his piety, he is even praised by God in the angelic council. Satan, a sceptical archangel, offers an experiment to test whether Job's piety is really sincere or predicated on his God-given wealth. With God's permission, Satan sends a series of catastrophes, from economic disaster to the death of Job's children.

“The Lord gave, and the Lord hath taken away: blessed be the name of the Lord,” responds Job, adding, “Naked …
Postprandial Oscillatory Patterns of Blood Glucose and Insulin in NIDDM: Abnormal Diurnal Insulin Secretion Patterns and Glucose Homeostasis Independent of Obesity
Authors: Jorge Calles-Escandon, Jonathan Jaspan, David C Robbins
Journal: Diabetes Care (1989)

Compared with control subjects, non-insulin-dependent diabetes mellitus (NIDDM) subjects had both quantitative and qualitative abnormalities in blood insulin and glucose concentrations. The purpose of this study was to determine whether and to what extent normally observed multiphasic patterns of insulin and glucose responses to mixed meals are deranged in NIDDM. A total of 24 volunteers were studied while eating three meals of identical composition at 0745, 1145, and 1645. Twelve had NIDDM, and the remainder were healthy nondiabetic age- and weight-matched control subjects. Blood was withdrawn every 10 min from 0630 to 1930 for measurement of C-peptide, insulin, and glucose concentrations. Peaks were analyzed by computer-based algorithms. Diabetic volunteers displayed several differences from control subjects. First, although the number of insulin peaks was similar, there was aconsistent delay of 20-30 min in the appearance of the first postprandial peak. Second, insulin concentrations after lunch were higher than after breakfast, whereas the reverse pattern occurred in control subjects. Third, integrated glycemia was greater after breakfast than after lunch. Fourth, glucose concentrations decreased during the first 30 min after lunch, suggesting accelerated glucose disposal and/or enhanced suppression of endogenous glucose production at this time of day. These data demonstrate that insulin secretion and action and glucose homeostasis in NIDDM are more complex than commonly appreciated. This dynamic state is undetected unless there is frequent blood sampling for measurement of insulin and glucose. The quantitative and qualitative abnormalities that we observed in these parameters are independent of obesity and suggest the need to expand the pathophysiological definition of NIDDM.
Increased NADPH Oxidase Activity, gp91phox Expression, and Endothelium-Dependent Vasorelaxation During Neointima Formation in Rabbits
Authors: Tamara M. Paravicini, Lerna M. Gulluyan, Gregory J. Dusting, Grant R. Drummond
Journal: Circulation Research (2002)

Reactive oxygen species including superoxide and hydrogen peroxide are important mediators in atherogenesis. We investigated the enzymatic source of vascular superoxide and its role in endothelium-dependent vasorelaxation during neointima formation. Silastic collars positioned around carotid arteries of rabbits for 14 days induced neointimal thickening. Using lucigenin-enhanced chemiluminescence, superoxide production was detectable in collared artery sections, but not in controls, only after inactivation of endogenous Cu 2+ /Zn 2+ -superoxide dismutase (Cu 2+ /Zn 2+ -SOD) with diethyldithiocarbamate (DETCA). Dihydroethidium staining indicated that endothelium and adventitia were the major sites of superoxide generation. Superoxide production in DETCA-treated collared arteries was enhanced further by NADPH and was inhibited by diphenyleneiodonium, suggesting NADPH oxidase was the source of the radical in collared arteries. Moreover, real-time PCR demonstrated 11-fold higher expression of the gp91phox subunit of NADPH oxidase in collared arteries than in controls. In vascular reactivity studies, endothelium-dependent vasorelaxation to acetylcholine did not differ between collared and control sections. However, treatment with DETCA reduced relaxations to acetylcholine in collared rings, but not in controls. NADPH further reduced relaxations to acetylcholine in DETCA-treated collared sections, but not in controls. In DETCA/NADPH-treated collared rings, sensitivity to nitroprusside, in contrast to acetylcholine, exceeded that of controls. Moreover, further treatment of such rings with exogenous Cu 2+ /Zn 2+ -SOD restored acetylcholine relaxations without altering nitroprusside responses. Thus, early neointimal lesions induced by periarterial collars are associated with elevated gp91phox expression and increased NAPDH-oxidase-dependent superoxide production in endothelium and adventitia. However, endothelium-dependent vasorelaxation is largely preserved due to the actions of Cu 2+ /Zn 2+ -SOD and increased smooth muscle sensitivity to nitric oxide.
Woman who had attended euthanasia workshop kills herself
Authors: C. Zinn
Journal: BMJ (2002)

The prime minister has called it appalling, and police are investigating the role of controversial euthanasia advocate Dr Philip Nitschke, after a 79 year old woman killed herself after saying she was tired of living.

The death last month of retired, French born academic Lisette Nigot has reignited the euthanasia debate in Australia, because she had attended one of Doctor Nitschke's euthanasia workshops two years ago and stayed in touch.

Dr Nitschke said he tried to dissuade her, but Ms Nigot had been hoarding the barbiturates (secobarbital (Seconal)) she had used for many years. “I tried to talk her out of it, but it seemed to me she was determined to take the final step,” he said.

He …
Abstract 18133: Variations of Circulating Levels of Insulin-Like Growth Factor 1 Impact Two-Years Clinical Outcome Following Acute Myocardial Infarction.
Authors: Olivier Bourron, Yves Le Bouc, Salma Kotti-tounsi, Nicolas Danchin, Nadeege Brunel, Bernard Ritz, Florence Leclercq, Xavier Tabone, Elodie Drouet, Genevieve Mulak, Tabassome Simon
Journal: Circulation (2010)

Background: Levels of insulin-like growth factor-1 (IGF-1) have been related to future type 2 diabetes and atherosclerosis. Few small studies have examined the impact of IGF-1 serum levels on cardi...
Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: a preclinical study
Authors: Hind Guenou, Xavier Nissan, Fernando Larcher, Jessica Feteira, Gilles Lemaitre, Manoubia Saidani, Marcela Del Rio, Christine C Barrault, François-Xavier Bernard, Marc Peschanski, Christine Baldeschi, Gilles Waksman
Journal: The Lancet (2009)
Autologous peripheral stem cell transplantation of the blastic phase of chronic myeloid leukemia following sequential high‐dose cytosine arabinoside and melphalan
Authors: Ursula A. Matulonis, James D. Griffin, George P. Canellos
Journal: American Journal of Hematology (1994)

Abstract Blast‐phase chronic myelogenous leukemia (CML) is the terminal phase in CML and is uniformly fatal. We treated 12 patients with blast‐phase CML with a program of high‐dose cytarabine 3.0 g/m 2 and melphalan 140 mg/m 2 . followed by reinfusion of stem cells obtained from peripheral blood during the chronic phase. Seven patients achieved either a partial or complete hematologic remission, while five patients showed no response to therapy. One petlent returned to chronic phase features with loss of a chromosomal abnormality acquired at blast phase, restoration of he matopolesis, and a decrease In the amount of bone marrow blasts to less than 10%. SIX patients cleared their peripheral blasts and showed recovery of their myelold and platelet lineages, but all six required treatment for acceleration within 3 months. Of the five nonresponding patients, three died with aplastlc bone marrow, one patient never cleared peripheral blasts after chemotherapy, and one patient had evidence of peripheral blasts 3 weeks after the autologous stem cell reinfuslon. None of the patients returned to a normal karyotype. The ablative regimen was effective in eradicating bone marrow blasts to &lt;10% in 8 of 10 patients in whom interpretable bone marrow samples were performed following chemotherapy. Overall, the median survival for all patients from the time of stem cell reinfusion was 5.5 months. We conclude that autotransplants with peripheral blood can successfully be used to support hematopoiesis during high‐dose therapy for CML blast crisis, however, has no role by itself in the curative therapy of blast crisis CML. A small number of patients can be restored to chronic phase features, and this may provide an opportunity to administer subsequent alternative treatments designed to eradicate the malignant stem cell population. Autotransplants with stem cells may also be used as therapy for patients without a histocompatible marrow donor. However, the autotransplant may be more effective when used during the chronic phase of CML, with the use of hematopoletlc growth factors, and with reinfusion of stem cells depleted of the malignant Philadelphia chromosomepositlve clone. © 1994 Wiley‐Liss, Inc.
Exercise and Fitness: A Collection of Papers Presented at the Colloquium on Exercise and Fitness, Robert Allerton Park, Monticello, Illinois, December 6-8, 1959
Authors: Frederic T. Jung
Journal: JAMA (1961)

Twenty substantial chapters by as many authors make up this inconspicuous but important book. They are grouped into 5 sections. The first 4 deal with the medical, physiological, nutritional, and psychological aspects of fitness and exercise and the fifth relates exercise and fitness to physical education. Much fundamental scientific work is critically summarized in some chapters; in others, the applications are described in commendable detail. Renewed efforts are made to crystallize the concept of fitness, to define it in operational terms, to make concrete recommendations about food and drink before and during athletic competition, and to appraise present-day programs of physical activity in schools and YMCA's. This book illustrates the advantages of bringing together experts from various fields for systematic consideration of a common area of interest. Several instances of muddled thinking and incongruous practices can be found in it, and the reader can console himself with the thought that