tbuckley/cabot-search huggingface dataset:
Clinical Experience with a Long Sliding Tube for Coloscopy
Authors: Y. Nakae, K. Nagasako, H. Sasaki, G. Aoki, T. Takemoto
Journal: Endoscopy (1975)

With a long sliding tube, it is easy to insert a coloscope into the ileocecal area. The long sliding tube holds the transverse colon in an ideal raised shape (convex curve) as well as the sigmoid colon straight. Inserting and drawing of a scope can be done through the long sliding tube. Therefore, it is possible to remove multiple polyps excised by polypectomy and replace a colonoscope by intestinoscope, magnifying endoscope and another coloscope with good image through this tube. The advantage of using a long sliding tube as proved in actual performances on patients.
The adenosine triphosphate content and lactic acid production of guinea-pig skin after mild heat damage
Authors: SHIRLEY A. CARNEY, M. HALL, C.R. RICKETTS
Journal: British Journal of Dermatology (1976)

The depletion of adenosine triphosphate in skin after mild thermal injury is not large enough to be accounted for by loss of oxidative respiration. Measurement of lactic acid production by skin suggest that glycolysis is less sensitive to heat damage than is oxygen uptake. It is therefore likely that glycolysis makes a large contribution to the relatively high levels of ATP persisting in heat damaged skin.
Device maker in libel case is ordered to pay 200 000 into court
Authors: C. Dyer
Journal: BMJ (2010)

The US based medical device maker which is suing British interventional cardiologist Peter Wilmshurst for libel over comments he made about a clinical trial of its septal repair implant has been ordered to pay £200 000 (€238 000; $311 000) into the high court in London if it wants to continue with its action against him.

The court has ruled that NMT Medical must pay the money into court by 18 January or its claim will be struck out and the court will make a costs order against the company in Dr Wilmshurst’s favour.

He has …
TEEN KNOWLEDGE OF LIFE-LONG CONGENITAL CARDIAC CARE
Authors: Susan M. Fernandes, Amy Verstappen, Mathieu Clair, Mary Rummell, Joseph Mares, Kirsten Dummer, Deena Barber, Stephen Crumb, Ami Bhatt, Mary Cannobio, Masato Takahashi, Roberta Williams, Michael Landzberg
Journal: Journal of the American College of Cardiology (2013)
Peak expiratory flow in symptomless elderly smokers and ex-smokers.
Authors: I. Gregg, A. J. Nunn
Journal: BMJ (1989)

Values of peak expiratory flow (PEF) in 142 current smokers (116 men, 26 women) and 108 ex-smokers (88 men, 20 women) aged 55 or over were compared with the predicted values obtained in lifelong nonsmokers of the same age range. None of the subjects had been liable during childhood or subsequently to expectoration, lower respiratory tract infection, wheeze, or shortness of breath. Observed values of PEF were expressed as differences from predicted. Analysis of the relation between smoking state and ventilatory function in the men disclosed significant reductions of PEF in current smokers, the deficits increasing with the amount smoked from a mean of 48.1 l/min in those smoking fewer than 20 cigarettes a day to 73.3 l/min in smokers of 20 or more a day. Significant reductions of PEF were also found in women who were currently smoking (mean 47.4 l/min) and in male ex-smokers of 20 or more cigarettes a day (mean 27.8 l/min). There was no significant reduction of PEF in male or female ex-smokers of fewer than 20 cigarettes a day. These findings suggest that factors besides smoking are concerned in the development of irreversible airflow obstruction.
Passive donor-to-recipient transfer of antiphospholipid syndrome following allogeneic stem-cell transplantation
Authors: D.S. Ritchie, A. Sainani, A. D'Souza, A.P. Grigg
Journal: American Journal of Hematology (2005)

Autoantibody production following allogeneic stem-cell transplantation is common and is often ascribed to the immune dysregulation associated with graft-versus-host disease. Recent data suggests that donor-memory B cells can be reactivated on exposure to antigen and result in antibody production in the recipient identical to that seen in the donor. Here we describe the production of autoantibodies in a recipient of bone marrow from a donor with systemic lupus erythematosus and antiphospholipid syndrome. Autoantibody appearance was precipitated by the onset of graft-versus-host disease, was identical to that of the donor, and ultimately lead to cerebrovascular thrombosis, which was successfully treated with antiplatelet and anticoagulant therapy. Am. J. Hematol. 79:299–302, 2005. © 2005 Wiley-Liss, Inc.
Hemispheric Arteriovenous Malformation
Authors: John Mark Vermillion, F.S. Harris
Journal: New England Journal of Medicine (2004)

Texas A&M Health Science Center Temple, TX 76508 valuation of a 23-year-old man with a history of tonic–clonic seizures revealed an arteriovenous malformation in the right parietal region of the brain (Panel A, arrow). Angiographic study of the internal carotid artery (Panel B, large arrow) delineated the malformation in the middle-cerebral-artery distribution, with draining veins (Panel B, small arrows) to the superior sagittal sinus. The patient underwent embolization followed by surgical resection, resulting in left hemiparesis. Three years later, the patient has weakness of his distal left arm but is functioning well and has no seizures. Cerebral arteriovenous malformations are the result of secondary progressive dilatation of a congenital arteriovenous fistula. Most patients with arteriovenous malformations present in the first two decades of life. The most common signs and symptoms are hemorrhage and seizures.
Treatment of immune thrombocytopenia associated with interferon therapy of hepatitis C with the anti-CD20 monoclonal antibody, rituximab
Authors: Ilene C. Weitz
Journal: American Journal of Hematology (2005)

This case report describes a patient with hepatitis C virus infection responding to pegylated INF/ribaviron therapy, who developed immune thrombocytopenia. The severe thrombocytopenia failed to resolve with cessation of the peg-IFN/ribaviron. Because of rising hepatitis C virus RNA levels and evidence of rising serum transaminases, the patient was treated with rituximab, anti-CD20 humanized monoclonal antibody. After treatment with rituximab, the patient's platelet count normalized and the patient was able to resume the pegylated IFN/ribaviron. The patient's hepatitis C virus RNA levels decreased, and the serum transaminases normalized without impairment of hepatic function or recurrence of the thrombocytopenia. Am. J. Hematol. 78:138–141, 2005. © 2005 Wiley-Liss, Inc.
Psychosocial factors and incident asthma hospital admissions in the EPIC‐Norfolk cohort study
Authors: N. W. J. Wainwright, P. G. Surtees, N. J. Wareham, B. D. W. Harrison
Journal: Allergy (2007)

Background: Case series and case‐control studies have shown high rates of psychosocial and behavioural risk factors amongst patients admitted to hospital with severe asthma. General population studies have shown associations between psychosocial factors and prevalent asthma but few have investigated incident asthma outcomes. Methods: Data on psychosocial factors and asthma hospital admissions were available for 20 854 participants, aged 41–80 years, in the Norfolk cohort of the European Prospective Investigation into Cancer study. Postal assessments included details of physical functioning, mood disorder history, social adversity and social support. Results: A total of 686 asthma hospital admissions were recorded. Psychosocial factors present at baseline, including current mood disorders, adverse circumstances in childhood, the impact of life events experienced during adulthood and negative perceived support from a close confidant, were associated with increased rates of hospital admission independent of age, sex, indicators of socio‐economic status, physical functional health, and obesity. Restricted to those participants who reported lifetime doctor‐diagnosed asthma at baseline, the reported impact of adverse life events experienced in adulthood, and both confiding and negative aspects of support quality, were associated with asthma hospital admission. The magnitude of these associations was comparable to those involving indicators of socio‐economic status and physical health. Conclusions: These results show that psychosocial factors are associated with incident asthma hospital admissions and highlight the potential importance of taking account of psychosocial factors, including availability and quality of support networks, in guiding long‐term asthma management.
Follow-Up of Children Overexposed to Lead
Authors: R. E. Albert, R. E. Shore, A. J. Sayers, C. Strehlow, T. J. Kneip, B. S. Pasternack, A. J. Friedhoff, F. Covan, J. A. Cimino
Journal: Environmental Health Perspectives (1974)

The purpose of this study is to assess the nature and magnitude of the deleterious health effects of subclinical over-exposure to lead in children.The study stems from concerns about the impact on the health of children in city slums who ingest leaded paint without overt evidence of poisoning and the health implication of rising levels of lead in the environment from automotive emissions.The study sample was derived mainly from a registry of children on whom blood lead determinations had been made by the New York City Department of Health and was supplemented by siblings of the registry cases and children from a lead belt area who had extractions of deciduous teeth in dental clinics.Information was obtained through parental interview, medical records, and psy- chometric evaluation.The data show that deleterious health effects occur in children who were treated for severe lead poisoning and in children without diagnosed lead poisoning who had elevated blood leads (>0.06 mg-%).In the absence of diagnosed lead poisoning or elevated blood leads, excess lead exposure, measured in terms of high levels of lead in teeth, was not associated with deleterious health effects.
Clinical and Investigative Application of a New Instrument for Continuous Recording of Blood Pressure and Heart Rate
Authors: John C. Rose, Saul R. Gilford, Herbert P. Broida, Anton Soler, Edward A. Partenope, Edward D. Freis
Journal: New England Journal of Medicine (1953)

IN both routine hospital practice and clinical investigation, there has long been a need for an instrument that will continually record blood pressure and heart rate without discomfort to the patient.The instrument used in the present study was designed and constructed by Gilford and his associates.1 This "physiologic monitor" is primarily intended for use by the anesthesiologist, providing him with a continuous record of the patient's blood pressure, heart rate, respiratory rate and minute respiratory volume, at the same time freeing him for other and occasionally more urgent duties in the operating room. The monitor also provides an instantaneous . . .
Determinants of myocardial hemorrhage after coronary reperfusion in the anesthetized dog.
Authors: L A Higginson, F White, H A Heggtveit, T M Sanders, C M Bloor, J W Covell
Journal: Circulation (1982)

Intramyocardial hemorrhage often occurs with reperfusion in experimental acute myocardial infarction and is thought to be associated with extension of necrosis. To determine if hemorrhage was associated with extension of necrosis, 20 anesthetized dogs were reperfused after 6 hours of circumflex coronary artery occlusion and 10 others had control occlusion with no reperfusion. Fifteen of the 20 reperfused dogs had gross hemorrhage and none of the control dogs did. In 12 reperfused and 10 control dogs, radioactive microspheres were injected after coronary occlusion to quantitate collateral flow and in the reperfusion group microspheres were injected to quantitative reflow. Complete flow data were available in eight reperfused and 10 control dogs. Twenty-four hours after coronary occlusion, 1-g segments of infarct and control regions were analyzed for hemorrhage, collateral flow and creatine kinase activity. Serial microscopic examination was performed in eight additional dogs reperfused after 6 hours to determine if hemorrhage occurs into otherwise microscopically normal myocardium. Pathologic examination indicated that hemorrhage did not occur into otherwise microscopically normal myocardium. In dogs with hemorrhage, the extent of hemorrhage was inversely related to myocardial creatine kinase concentration and collateral flow. Mean collateral flow in 47 hemorrhagic segments was 4.5 ml/100 g (4.2% of control). Mean creatine kinase in 36 hemorrhagic segments was 233 mIU/g (21% of control). No hemorrhage was found in areas with collateral flow more than 21% of control or creatine kinase more than 37% of control. Mean reflow in hemorrhagic segments was 78.5% of control flow. These studies indicate that hemorrhage on reperfusion is associated with severe myocardial necrosis and markedly depressed flow before reperfusion and thus occurs only into myocardium already markedly compromised at the time of reperfusion. There is no evidence for hemorrhage into areas that had normal or even moderately depressed flows before reperfusion.
WHAT EFFECTIVE MEASURES ARE THERE FOR THE PREVENTION OF THE SPREAD OF SYPHILIS AND THE INCREASE OF PROSTITUTION?
Authors: CHARLES GREENE CUMSTON
Journal: JAMA (1906)

It is not to be supposed that there exists at the present time a single moralist sufficiently severe, or rather insufficiently enlightened, who would dare to doubt the necessity of measures capable of combating the propagation of venereal diseases. Fortunately, the time has past when syphilis was believed to be the unique result of depravation and was considered as the legitimate punishment of debauch. The numerous sources of infection are too well known at the present time to uphold the old rigorous theories and to these I shall not revert. Of all the diseases which may affect the human race by contagion and which bring about the greatest disasters to society in general, there is not one more serious, more dangerous, or more to be feared than syphilis. This, I believe, is generally admitted, and since this is the case, why should not the proper authority profit by the knowledge
The Diagnosis of Reversible Renal Hypertension.
Authors: Victor Vertes
Journal: Annals of Internal Medicine (1964)

s1 October 1964The Diagnosis of Reversible Renal Hypertension.Victor Vertes, M.D., J. Grauel, M.D.Victor Vertes, M.D.Search for more papers by this author, J. Grauel, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-816_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe renal origin of hypertension is well established in cases of main renal artery stenosis or unilateral intra-renal disease. Surgical repair of diseased renal arteries or unilateral nephrectomy can correct the hypertension in many instances. An unselected series of 150 hypertensive patients were admitted to the metabolic unit for investigation of the possible presence of renovascular hypertension. Separate renal function studies utilizing the technique described by Stamey were obtained on all of the patients. Transfemoral aortography and percutaneous renal biopsies were also performed on over 50 of the patients.Stenosis of the main renal artery was demonstrated by aortography in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1964Volume 61, Issue 4Page: 816-816KeywordsBiopsyHypertensionNephrectomyRenal arteriesRenal diseasesStenosisSurgical repair Issue Published: 1 October 1964 PDF downloadLoading ...
Respiratory Function of the Placenta as Determined with Carbon Monoxide in Sheep and Dogs*
Authors: Lawrence D. Longo, Gordon G. Power, Robert E. Forster
Journal: Journal of Clinical Investigation (1967)

A technique is described for studying the respiratory function of the placenta using carbon monoxide, a gas whose exchange across the placenta between the maternal and fetal circulations is limited by diffusion rather than blood flow. During the steady state before the introduction of CO, the normal concentration of carboxyhemoglobin in the ewe, [COHb](M), is approximately 0.90%, and that in the fetus is 2.9%, the ratio [COHb](F)/[COHb](M) being 3.2. In dogs the corresponding values are 1.9%, 4.8%, and 2.4%. After the introduction of CO into the mother animal, CO diffused across the placenta slowly with an equilibration half-time of approximately 2 hours. The average carbon monoxide diffusing capacity (D(Pco)) of the placenta during maternal to fetal exchange was 0.54 ml per (minute x mm Hg x kg fetal weight) (SD +/- 0.13) in sheep and 0.57 ml per (minute x mm Hg x kg) (SD +/- 0.18) in dogs. The fetal to maternal placental diffusing capacity in two sheep was 0.54 ml per (minute x mm Hg x kg). Calculations considering the relative rates of reaction of O(2) and CO with red cell hemoglobin and the relative rates of diffusion of the two gases suggest that the true D(Po2) should be about 1.2 to 2 times greater than the D(Pco) or 0.65 to 1.1 per (minute x mm Hg x kg). This is about 5 times greater than the reported value of D(Po2) calculated from measurements of P(O2) in the mixed uterine and umbilical venous blood. With a diffusing capacity of this magnitude the maternal and fetal placental end capillary P(O2) would approach equilibrium, becoming too small to measure, and the calculation of D(Po2) would be unreliable. We suggest that the apparent end capillary P(o2) gradients of 15 to 20 mm Hg, obtained from sampling uterine and umbilical venous blood, result from a combination of uneven distribution of maternal and fetal placental blood flow and from placental oxygen consumption.
Etiologic role of unapparent exposure in cat allergy
Authors: J. V. Brasó‐Aznar, A. Pelaez‐Hernandez, A. Rochina‐Puchades, C. Morales‐Rubio, E. Burches‐Baixauli
Journal: Allergy (1995)

To determine the importance of unnoticed exposure to cat, we studied 20 patients with a history of respiratory allergy. All the patients had a positive prick test to cat dander extract, and none of them kept cats as pets. The prick test was carried out with a dander extract from cat at a concentration of 100 BU/ml. The specific IgE was determined by the commercially available Pharmacia CAP System. We carried out a conjunctival challenge test. The concentration of Fel d I was quantified in dust samples from the patients’ homes by a commercially available method. The patients were reassessed in order to establish a relation between exposure and symptoms, and concealed allergen sources. Sixteen patients, showed significant levels of Fel d I in their homes (mean of 3.35 μg g of dust). The conjunctival challenge test was positive in 15 patients. These patients showed an exposure mean of 0.4 μg/g of dust. The mean levels of specific serum IgE were higher in those patients with a positive challenge than in those with a negative challenge ( P = 0.0145). In nine reassessed patients, a relation was established between natural exposure and the onset of the symptoms. A possible hidden allergen source was established in 11 patients. Hidden exposure to cat allergen may play a role in the symptomatology of many atopic patients, and investigation of sensitization to Fel d I should be included in the routine allergologic evaluation of all patients with asthma or perennial rhinitis.
Diastolic Murmurs in Apparently Normal Children
Authors: JEROME LIEBMAN, SANTOSH SOOD
Journal: Circulation (1968)

Diastolic murmurs have always been considered abnormal, but this report presents nine apparently normal children with high-frequency, early, diamond-shaped diastolic murmurs confirmed by intracavitary phonocardiography to arise within the left ventricle. Each child (aged 5 to 15 years) was referred for evaluation of a systolic murmur at the lower left sternal border, but an additional finding at the initial examination was a grade I to III/VI high-pitched diastolic murmur, thought to be decrescendo, at the third and fourth intercostal space at the left sternal edge. The murmurs were best heard when the patient was supine. Cardiac x-rays, including four views with barium, were all clearly normal, as were eight of the nine electrocardiograms and the Frank and McFee vectorcardiograms. Multiple parameters of right and left heart catheterizations were normal in all.
HEALTH EDUCATION THROUGH COMPULSORY STATE DISABILITY COMPENSATION PROGRAMS
Authors: John E. Farrell
Journal: JAMA (1952)

In 1947, the Social Security Administration sent to the states recommendations for improving state unemployment insurance provisions during the state legislative sessions. The suggestion was advanced that the states might well expand their social insurance protection by providing for a system of cash benefits to workers when they are sick or temporarily disabled. Accompanying these recommendations was the statement, It makes little difference to workers, in terms of wage loss, whether they are unemployed because of lack of work or because of illness. As a matter of fact, the latter contingency places a double burden on workers because it results not only in cessation of earnings but in medical costs.... 1 In March of the same year, Arthur Altmeyer, Commissioner for Social Security, in a paper on the subject of temporary disability insurance coordinated with state unemployment insurance programs, paraphrased this same thought when he stated that, It is obviously
Message in a Bottle: The Making of Fetal Alcohol Syndrome
Authors: Raja A S Mukherjee
Journal: BMJ (2005)

F or every medical condition there is a moment in time when it was first recognised. The conditions exist before their discovery, of course, but their recognition often leads to further discoveries and new controversy. Few conditions have caused such polarisation of views or such scepticism as fetal alcohol syndrome. Janet Golden Harvard University Press, £16.95/€24/$25.95, pp 240 ISBN 0 674 01485 5 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> www.hup.harvard.edu/catalog/GOLMES.html As a history professor Janet Golden doesn't try to give … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif