tbuckley/cabot-search huggingface dataset:
Determinants of 6-month mortality in survivors of myocardial infarction after thrombolysis. Results of the GISSI-2 data base. The Ad hoc Working Group of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-2 Data Base.
Authors: A Volpi, C De Vita, M G Franzosi, E Geraci, A P Maggioni, F Mauri, E Negri, E Santoro, L Tavazzi, G Tognoni
Journal: Circulation (1993)

Current knowledge of risk assessment in survivors of myocardial infarction is largely based on data gathered before the advent of thrombolysis. It must be determined whether and to what extent available information and proposed criteria of prognostication are applicable in the thrombolytic era.We reassessed risk prediction in the 10,219 survivors of myocardial infarction with follow-up data available (ie, 98% of the total) who had been enrolled in the GISSI-2 trial, relying on a set of prespecified variables. The 3.5% 6-month all-cause mortality rate of these patients compared with the higher value of 4.6% found in the corresponding GISSI-1 cohort, originally allocated to streptokinase therapy, indicates a 24% reduction in postdischarge 6-month mortality. On multivariate analysis (Cox model), the following variables were predictors of 6-month all-cause mortality: ineligibility for exercise test for both cardiac (relative risk [RR], 3.30; 95% confidence interval [CI], 2.36-4.62) and noncardiac reasons (RR, 3.28; 95% CI, 2.23-4.72), early left ventricular failure (RR, 2.41; 95% CI, 1.87-3.09), echocardiographic evidence of recovery phase left ventricular dysfunction (RR, 2.30; 95% CI, 1.78-2.98), advanced (more than 70 years) age (RR, 1.81; 95% CI, 1.43-2.30), electrical instability (ie, frequent and/or complex ventricular arrhythmias) (RR, 1.70; 95% CI, 1.32-2.19), late left ventricular failure (RR, 1.54; 95% CI, 1.17-2.03), previous myocardial infarction (RR, 1.47; 95% CI, 1.14-1.89), and a history of treated hypertension (RR, 1.32; 95% CI, 1.05-1.65). Early post-myocardial infarction angina, a positive exercise test, female sex, history of angina, history of insulin-dependent diabetes, and anterior site of myocardial infarction were not risk predictors. On further multivariate analysis, performed on 8315 patients with the echocardiographic indicator of left ventricular dysfunction available, only previous myocardial infarction was not retained as an independent risk predictor.A decline in 6-month mortality of myocardial infarction survivors, seen within 6 hours of symptom onset, has been observed in recent years. Ineligibility for exercise test, early left ventricular failure, and recovery-phase left ventricular dysfunction are the most powerful (RR, > 2) predictors of 6-month mortality among patients recovering from myocardial infarction after thrombolysis. Qualitative variables reflecting residual myocardial ischemia do not appear to be risk predictors. The lack of an independent adverse influence of early post-myocardial infarction angina on 6-month survival represents a major difference between this study and those of the prethrombolytic era.
Abstract 1109: The antimicrobial peptide LL37 activates plasmacytoid dendritic cells in breast cancer
Authors: Nelly Vey, Elena Blanc, Vanja Sisirak, Sandra Thys, Céline Le Beux, Nadège Goutagny, Isabelle Treilleux, Aurélien Marabelle, Jean-Yves Blay, Christophe Caux, Nathalie Bendriss-Vermare
Journal: Cancer Research (2014)

Abstract Plasmacytoid dendritic cells (pDC) are the main producers of type I IFNs in response to viral and self nucleic acids that trigger endosomal TLR7 and 9. They have been recently described in various solid tumors. In breast tumors, we demonstrated that tumor-associated (TA)pDC exhibit a partially mature phenotype, suggesting that endogenous activating signals are present in tumor microenvironment (TME). Importantly, type I IFN was shown to play a major role in tumor immunosurveillance and we observed a type I IFN signature in human breast tumors. Altogether these observations lead us to investigate whether, in the initiating phase of tumorigenesis, TApDC might be activated by endogenous TLR ligands released in the TME that may trigger their IFN-a production, as observed in auto-immune disorders in response to [self nucleic acids-antimicrobial peptide LL37] complexes. First, we demonstrated that hCAP18/LL37 is expressed by a subset of CD45+ cells within the breast TME. Importantly, [self nucleic acids-LL37] complexes purified from breast TME were able to trigger IFN-a production in healthy pDC in vitro demonstrating their functionality. Finally, using syngenic murine mammary tumor models preliminary data showed that tumor cell growth is accelerated in IFNARko mice and pDC-depleted mice compared to wild-type mice suggesting a role for type I IFN and pDC in controlling early tumor development. Thus, our work aimed at demonstrating that restoring pDCs' immunosurveillance function might represent an attractive therapeutic strategy for localized breast tumors. Support : Ligue contre le cancer, Fondation ARC (SFI20111203835) and INCA (2011-1-PL BIO-12-IC-1). Citation Format: Nelly Vey, Elena Blanc, Vanja Sisirak, Sandra Thys, Céline Le Beux, Nadège Goutagny, Isabelle Treilleux, Aurélien Marabelle, Jean-Yves Blay, Christophe Caux, Nathalie Bendriss-Vermare. The antimicrobial peptide LL37 activates plasmacytoid dendritic cells in breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1109. doi:10.1158/1538-7445.AM2014-1109
Functional abdominal pain: further evidence that whole gut is affected.
Authors: K J Moriarty, A M Dawson
Journal: BMJ (1982)

The distribution and referral of abdominal pain in 21 patients with functional abdominal pain were investigated by performing balloon distension of the ileum, proximal jejunum, second part of the duodenum, and distal oesophagus. Pain was perceived not just in classically described sites but throughout the abdomen and was referred to several unusual extra-abdominal sites. The presenting pain was reproduced by this technique in 14 patients, in three of whom it was also reproduced by colonoscopic distension. This study emphasises the protean presentation of functional abdominal pain and demonstrates the existence of potentially tender "trigger" areas for the production of abdominal pain in the proximal as well as the distal gut.
Influence of chronic lactulose ingestion on the colonic metabolism of lactulose in man (an in vivo study).
Authors: C Florent, B Flourie, A Leblond, M Rautureau, J J Bernier, J C Rambaud
Journal: Journal of Clinical Investigation (1985)

The effects of a chronic load of nonabsorbable sugars on intracolonic bacterial metabolism of carbohydrates and on H2 breath excretion are disputed. However, most of the discussion relies on indirect evidence or on results of in vitro studies. Thus, we attempted to assess directly and in vivo the effects on intracolonic metabolism of lactulose of a chronic oral load of this nonabsorbable disaccharide. 20 g of lactulose was given orally twice daily during 8 d to eight normal volunteers. In all, breath H2 concentration was measured on days 1 and 8 after ingestion of the morning lactulose dose. In four subjects, stools were collected during 2 d at the beginning and at the end of the lactulose maintenance period to measure fecal pH and daily outputs of carbohydrates and beta-galactosidase. The four other subjects were intubated on days 1 and 8 to measure the pH and the concentrations of carbohydrates, lactic acid, and volatile fatty acids (VFA) in the distal ileum and cecal contents. Moreover, 14C-lactulose was added to cold lactulose and 14CO2 breath outputs determined. Pulmonary H2 excretion fell from day 1 to day 8 (P less than 0.05), whereas 14CO2 excretion increased (P less than 0.01). Fecal water pH, lactic acid, and VFA concentrations did not vary between the two stool collection periods. 24-h fecal weight, fecal water, and carbohydrate outputs showed a trend to decrease between days 1 and 2 and days 7-8, whereas beta-galactosidase activity rose markedly (P less than 0.01). No significant variations were observed for all parameters measured in ileal fluid. In the cecum, areas under the concentration curves decreased from day 1 to day 8 for lactulose, galactose, and fructose (P less than 0.01), while an increase was found for lactic acid (P less than 0.001), acetic acid (P less than 0.0001), and total VFA (P less than 0.001). Cecal fluid pH dropped faster (P less than 0.05) and to a lower level (P less than 0.05) on day 8 than on day 1. These data clearly show that a chronic load of a nonabsorbable sugar induces changes in colonic bacterial metabolic pathways resulting in a better efficiency of the flora to digest the carbohydrate.
Modernising the NHS: Prevention and the reduction of health inequalities
Authors: S. Macintyre
Journal: BMJ (2000)

In the state of Delaware, approximately 50% of the rivers have total phosphorus (P) concentrations greater than 0.1 mg L<sup>−1</sup>, the concentration above which freshwater bodies are considered impaired by P. The structural best management practice commonly recommended by advisory agencies to control nonpoint P loss is the vegetated filter strip (VFS). In the Coastal Plain region of Delaware, where P saturated soils are commonly found, VFS should trap particulate P, but their effectiveness at preventing dissolved P losses is less certain. The objectives of this research were (1) to develop a rapid soil test to determine if a VFS has the potential to adequately mitigate dissolved P in agricultural runoff at a designated site and (2) to determine, in laboratory tillage simulation studies, if deep tillage prior to VFS planting can improve dissolved P retention within VFS. Soil samples were collected from existing VFS and adjacent fields, as well as from field margins where new VFS were to be planted, and were characterized for organic matter, water pH, water soluble P, Mehlich 3 extractable elements (P, Al, and Fe), and Mehlich 3 P Saturation ratio (M3-PSR). A subset of soils was selected to characterize P sorption and desorption properties of the VFS, including total P sorption capacity (PSC<sub>t</sub>), remaining P sorption capacity (PSC<sub>r</sub>), and the equilibrium P concentration at zero sorption (EPC<sub>0</sub>). Both the ratio of PSC<sub>r</sub> to PSC<sub>t</sub> (an estimate of the percentage of remaining P sorption capacity) and EPC<sub>0</sub> were well correlated with M3-PSR (<i>r</i><sup>2</sup>= 0.92, 0.93). Simulated deep tillage decreased M3-P by 62% compared with surface soils and decreased PSR by as much as 70%. Study results suggest that the M3-PSR soil test can lead to a better understanding of whether a VFS installed at a particular site can be expected to retain dissolved P in agricultural runoff. Likewise, M3-PSR can also be used to determine if deep tillage prior to VFS installation will be beneficial for overall dissolved P management.
Breast Mass in a 69-Year-Old Woman
Authors: George Hermann
Journal: JAMA (1986)

A 69-year-old woman was initially seen with a mass in the right breast of four days' duration. <h3>Clinical History</h3> A 69-year-old woman was initially seen with constant abdominal pain in the epigastrium and right upper quadrant, with nausea and vomiting of three days' duration. On examination, moderate tenderness and guarding in the right upper quadrant of the abdomen were noted. A leukocytosis of 11,000/cu mm, with a mild shift to the left, was present. Findings from a sonogram and hepatobiliary scan were consistent with a diagnosis of acute cholecystitis for which intravenous (IV) antibiotic therapy was instituted. Results of radiological studies performed on the second hospital day showed a small-bowel obstruction. On surgical exploration, a gangrenous segment of the terminal ileum was resected and an end-to-end anastomosis was performed. The resected bowel demonstrated hemorrhagic infarction with evidence of focal organizing venous thrombosis in the mesentery. The patient was initially started
Busulphan toxicity syndrome caused by chlorambucil.
Authors: M S Rose
Journal: BMJ (1975)

The risk to the patient and the fetus if the uterus ruptures is serious and even when mother and baby survive the mother's future child- bearing capacity is usually lost.Clearly, uterine hyperstimulation must always be avoided and oxytocin and prostaglandin should not generally be used in the grandmultipara or the patient who has previously had a caesarean section.If it is felt necessary to use these agents then continuous monitoring of labour is essential, especially if epidural analgesia is to be employed.
Gender Identity Disturbances in Intersexed Patients
Authors: LAWRENCE E. NEWMAN, ROBERT J. STOLLER
Journal: American Journal of Psychiatry (1968)

The outward manifestations of gender role may conceal an aberration of gender identity in intersexed patients. The authors present the case of a woman with pseudohermaphroditism whose apparent femininity concealed an ambiguous gender identity. The mother's early uncertainty about the child's sex led to this disorder. Physicians involved in the treatment of intersexed patients should be aware of this kind of problem.
ABNORMALITIES OF CARBOHYDRATE METABOLISM OF RED CELLS IN HEREDITARY SPHEROCYTOSIS 12
Authors: Thomas A. J. Prankerd, Kurt I. Altman, Lawrence E. Young
Journal: Journal of Clinical Investigation (1955)

We have recently described a method for in- vestigating glycolysis of red cells by using P8-2 labeled orthophosphate to measure the rate of turnover of various organic phosphate esters (1).Observations on normal cells incubated under vari- ous conditions have been made with this method and described in separate reports (2, 3).Be- cause inborn errors of metabolism have been demonstrated in a variety of hereditary diseases, this method has been applied especially to the study of red cells from patients with certain congenital hemolytic disorders.We have focused our at- tention particularly upon hereditary spherocytosis (to be abbreviated as HS) and will report results obtained from patients with this disorder in this paper.Our findings in other hemolytic states, both congenital and acquired, will be described later. METHODSThe methods of estimating the rate of incorporation of radioactive orthophosphate into phosphate esters of the red cell have been described previously in detail (1, 2).Freshly drawn heparinized blood was incubated at 37.50 C. with 0.05 to 0.15 ml. of 0.0007 N NaH,P'O, having approximately 10' counts per minute (c.p.m.) and at appropriate intervals the phosphorus com- pounds were extracted with trichloracetic acid from samples of red cell stroma and from the remaining in- tracellular material.From these extracts the phosphoruscontaining compounds were isolated by paper chromatog-
A Case of Guillain-Barré Syndrome with Immunologic Abnormalities
Authors: CHRISTOPHER J. FROELICH
Journal: Annals of Internal Medicine (1980)

Guillain-Barré syndrome and the nephrotic syndrome developed in a patient simultaneously. Analysis of renal biopsy by light, immunofluorescent, and electron microscopy showed lipoid nephrosis. T-cell lymphocytopenia, lymphocytotoxic antibodies, depressed lymphocyte mitogenesis, and anergy also complicated the illness. The immunologic abnormalities resolved when the polyradiculoneuritis and lipoid nephrosis remitted. This previously undescribed association illustrates the occurrence of two postulated cell-mediated autoimmune disorders despite the presence of depressed cell-mediated immunity.
Antioxidant dietary suppelementation with vitamin E decreased atherosclerosis and cellular proliferation in lipid-fed rabbits exposed to passive smoking
Authors: Bo-qing Zhu, Yi-ping Sun, Richard E. Sievers, Edward P. Norkus, Stanton A. Glantz, Bing-yin Wang, John P. Cooke, William W. Parmley, Prakash C. Deedwania
Journal: Journal of the American College of Cardiology (1996)
Birth weight and adult lung function in China
Authors: Y B CHEUNG
Journal: Thorax (2001)

Myositis associated with graft-versus-hostdisease (GVHD) typically presents with proximal muscle weakness, myalgias, and a raised creatinine phosphokinase (CPK) level.We report a case of a 51 year old man who developed respiratory muscle weakness five years after an allogeneic bone marrow transplant for multiple myeloma.His symptoms included tachypnoea, abdominal paradox, and orthopnoea.Pulmonary function tests revealed diminished vital capacity and maximal inspiratory and expiratory pressures.Serum CPK levels were raised and a peripheral muscle biopsy specimen was consistent with GVHD.He improved with immunosuppressive therapy.
Abstract 3201: Identification of the type 2 cystatins (SA/SN) as a novel biomarkers for stress-induced senescence in human non-small cell lung cancer lines
Authors: Guanjun Cheng, Liang-Chuan S. Wang, Cecilia Crisanti, Jing Sun, Veena Kapoor, Steven M. Albelda
Journal: Cancer Research (2010)

Abstract Purpose: Stress-induced cellular senescence (SIS) is becoming increasingly well recognized as an important process in premalignant neoplastic lesions and the response to chemotherapeutic drugs and radiation. In addition, senescent cells may release growth factors, cytokines, proteases, and other factors that affect the tumor microenvironment. The standard maker of SIS (staining for β-galactoside [β-gal] at pH 6) cannot be used in fixed tissues. New and more consistent biomarkers of SIS that could be used in tissue sections are thus needed to improve early detection of premalignant lesison, to design and monitor cancer therapeutic approaches, and to gain additional mechanistic understanding. Experimental Procedures: Doxorubicin (Dox) was employed to induce senescence in A549 and L55 human non-small cell lung cancer lines. Gene expression profiles were compared in control vs Dox-treated A549 cells. Validation was carried out by real time quantitative PCR (qPCR). Type 2 Cystatin (SA/SN) protein expression levels were evaluated by immunoblotting and immunohistochemistry (IHC) using an antibody (Santa Cruz) that recognized both proteins. Results: Dox induced senescence of A549 and L55 cells as evidenced by cellular enlargement, cessation of proliferation, and positive staining for ß-gal at pH 6.0. Microarray screening revealed marked upregulation of the genes for Cystatin SA and SN, that was confirmed by qRT-PCR. High protein expression levels of type 2 cystatin (SA/SN) was demonstrated in Dox-treated cells by immunoblotting and IHC. IHC was successful in ethanol-fixed and formalin-fixed paraffin embedded slides. Conclusions: The cystatin superfamily is a well-established family of cysteine protease inhibitors that have been suggested to affect cell differentiation, growth, and migration through protease inhibition and by direct receptor mediated effects. The role of cystatin SA/SN in SIS is under study. However, our results identify two Type 2 Cystatins (SA/SN) that appear to be promising biomarkers for SIS in human non-small cell lung cancer. Cystatin staining could be utilized in fixed tissue sections to screen for oncogene-induced premalignant lesions and for studying the effects of chemotherapeutic drugs and radiation in lung cancer or bronchial biopsy samples. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3201.
Longest Survivor of Pulmonary Atresia With Ventricular Septal Defect
Authors: Daisuke Fukui, Hisashi Kai, Tomohiro Takeuchi, Takeki Gondo, Toyoharu Oba, Kazutoshi Mawatari, Tatsuo Tonai, Yu Matsuo, Shin-ichiro Ueda, Hiroshi Niiyama, Takafumi Ueno, Tsutomu Imaizumi
Journal: Circulation (2011)
Endometrial disease after treatment with oestrogens and progestogens in the climacteric.
Authors: M E Paterson, T Wade-Evans, D W Sturdee, M H Thom, J W Studd
Journal: BMJ (1980)

A prospective study of 745 women receiving different regimens of hormone treatment for the climacteric for a total of 21 736 months was performed. There was a lower incidence of endometrial hyperplasia in biopsy specimens in the women receiving cyclical low-dose oestrogen by mouth than in those receiving cyclical high-dose oestrogen by mouth. The incidence of abnormalities in the women receiving sequential oestrogen and progestogen was lower than in either of these two groups. Among the women receiving subcutaneous oestrogen implants the incidence was higher still, but over half of the abnormal specimens were from women who had not taken their progestogen. The incidence of hyperplasia fell with longer courses of progestogen, and no hyperplasia was found in patients taking progestogen for over 10 days each month. The incidence of adenomatous and atypical hyperplasia is significantly reduced by a progestogen when taken for 10 or more days monthly. The absence of vaginal bleeding or of a regular bleeding response does not guarantee histologically normal endometrium in patients taking oestrogens without progestogen.
The 80th year of fifth disease.
Authors: P P Mortimer
Journal: BMJ (1984)

use of scanning in research57 and information from other non-invasive measurements such as cerebral blood flow velocity have suggested that periventricular haemorrhage may be prevented by the employment of a sufficient number of skilled nurses and doctors to provide high quality care for ill preterm babies.'2-'4Our resources must be directed there rather than to the detection of periventricular haemorrhage after it has occurred.
Sustained response with rituximab in patients with thrombotic thrombocytopenic purpura: A report of 13 cases and review of the literature
Authors: Huichung T. Ling, Joshua J. Field, Morey A. Blinder
Journal: American Journal of Hematology (2009)

Idiopathic thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease mediated by autoantibodies directed against ADAMTS-13. A number of small series and case reports have shown promising results with rituximab in refractory or relapsed TTP. In this report, we present 13 patients with TTP treated with rituximab. Twelve of the 13 patients (92%) achieved complete response; no subsequent relapses occurred with median follow-up of 24 months (range, 13-84 months). The addition of rituximab to standard therapy appears to be effective in sustaining long-term remission in TTP. However, the optimal dosing and timing of rituximab warrant further investigation. Am. J. Hematol., 2009. (c) 2009 Wiley-Liss, Inc.
258. Identification of Differentially Expressed Genes in Duchenne Muscular Dystropy Utilising RNAi Technology: Possible Targets for Gene Therapy
Authors: Mohammad Mahdi Ghahramani Seno, Ian R. Graham, Ken Laing, Marita Pohlschmidt, Takis Athanasopoulos, Mark Crompton, George J. Dickson
Journal: Molecular Therapy (2005)

Duchenne Muscular Dystrophy (DMD) is one of a group of genetically heterogeneous muscular dystrophies that are characterized by progressive weakness and wasting of skeletal muscle. Loss of myofibres occurs in response to a deficiency of dystrophin, a protein which is believed to be responsible for myofibre maintenance and integrity. Dystrophin forms a link between the cytoskeleton and the membrane-spanning dystrophin-associated glycoprotein complex (DAPC), indicative of a structural role for dystrophin.