tbuckley/cabot-search huggingface dataset:
TCT-620 What Is The Optimal Revascularization Strategy For Percutaneous Coronary Intervention Of Distal Anastomotic Lesions After Coronary Bypass Surgery?
Authors: Salem Badr, Israel Barbash, Danny Dvir, Hironori Kitabata, Joshua Loh, Augusto Pichard, Gabriel Sardi, Lowell Satler, Rebecca Torguson, Ron Waksman
Journal: Journal of the American College of Cardiology (2012)
Fibrinogen Philadelphia. A hereditary hypodysfibrinogenemia characterized by fibrinogen hypercatabolism.
Authors: J Martinez, R R Holburn, S S Shapiro, A J Erslev
Journal: Journal of Clinical Investigation (1974)

A new, autosomally inherited abnormal fibrinogen associated with hypofibrinogenemia has been described in several members of a family. Plasma fibrinogen measured either as thrombin-clottable protein or by immunodiffusion revealed a fibrinogen level ranging between 60 and 90 mg/100 ml. The thrombin time of plasma or purified fibrinogen was prolonged and only partially corrected by the addition of calcium. Purified fibrinogen prolonged the thrombin time of normal plasma. Fibrinopeptide release by thrombin was normal in rate and amount, but fibrin monomer aggregation was grossly disturbed, especially in a high ionic strength medium. We have designated this fibrinogen "fibrinogen Philadelphia." Acrylamide gel electrophoresis of mixtures of [121I]normal and [125I]abnormal fibrinogens revealed a slight increase in the anodal mobility of fibrinogen Philadelphia. Similarly, DEAE-cellulose chromatography showed slightly stronger binding of fibrinogen Philadelphia than normal. To elucidate the mechanism responsible for the low plasma fibrinogen concentration, simultaneous metabolic studies of autologous (patient) and homologous (normal) fibrinogen, labeled with 125I and 121I, respectively, were performed in two affected subjects. Autologous fibrinogen half-life was short and the fractional catabolic rate was markedly increased in both family members. In contrast, homologous fibrinogen half-life and fractional catabolic rate were normal. These metabolic studies demonstrate that rapid degradation of fibrinogen Philadelphia is largely responsible for the depressed levels of a plasma fibrinogen. This represents the first example of a mutant plasma protein in which the molecular defect is associated with an altered catabolism.
664 PROTEOMIC ANALYSIS AND 2-D-GEL ELECTROPHORESIS OF BILE-DUCT BILE OF PRIMARY SCLEROSING CHOLANGITIS PATIENTS: A NEW DIAGNOSTIC APPROACH
Authors: D. Gotthardt, L. Reinhard, K.H. Weiss, W. Stremmel, D. Riedel, P. Sauer
Journal: Journal of Hepatology (2009)
Abstract 4840: DNA methyltransferase 3B as a mediator in cancer associated inflammation and progression
Authors: Nicolas G. Skrypek, B R. Achyut, Christine Hollander, Li Yang
Journal: Cancer Research (2014)

Abstract For a long time ignored, the tumor microenvironment is now known as an important contributor in tumor progression and metastasis. However, the molecular mechanisms as how cancer-associated inflammation promotes metastasis remain to be investigated. Previous work in our lab showed an inflammatory and immune suppressive microenvironment in the pre-metastatic lung prior to tumor cell arrival. Recently, we found that inflammation is responsible for down-regulation of cyclin-dependent kinase inhibitors p15, p16, and p21 in a mouse model of invasive squamous cell carcinoma, in which gene encoding TGFb receptor 2 (Tgfbr2) was deleted in the stromal fibroblasts (Tgfbr2fspKO). There was an induction of inflammation and significant DNA damage in the neighboring epithelia of the forestomach due to the stromal deletion of Tgfbr2. We found that an up-regulation of DNA methyltransferase 3B (DNMT3B) was responsible for these epigenetic alterations. Based on these studies, we hypothesize that the cancer-associated inflammation could induce DNMTs activity leading to the repression of genes important for inhibition of tumor progression. We are currently investigating the impact of inflammation on DNMTs expression using 4T1 mammary tumor models. We hope that our studies will provide insight for molecular mechanisms underlying tumor-host interaction in the metastatic process and identify the novel therapeutic targets. Citation Format: Nicolas G. Skrypek, B R. Achyut, Christine Hollander, Li Yang. DNA methyltransferase 3B as a mediator in cancer associated inflammation and progression. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4840. doi:10.1158/1538-7445.AM2014-4840
INCIDENCE, PREDICTORS AND IMPACT OF BLEEDING EVENTS AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT (TAVR) COMPARED TO SURGICAL AORTIC VALVE REPLACEMENT (SAVR): INSIGHTS FROM THE PARTNER TRIAL
Authors: Philippe Genereux, Lars Svensson, Susheel Kodali, Mathew Williams, Jeffrey Moses, Michael Mack, D. Craig Miller, E. Murat Tuzcu, John Webb, Craig Smith, Martin Leon
Journal: Journal of the American College of Cardiology (2012)
MicroRNA-21 Blocks Abdominal Aortic Aneurysm Development and Nicotine-Augmented Expansion
Authors: Lars Maegdefessel, Junya Azuma, Ryuji Toh, Alicia Deng, Denis R. Merk, Azad Raiesdana, Nicholas J. Leeper, Uwe Raaz, Anke M. Schoelmerich, Michael V. McConnell, Ronald L. Dalman, Joshua M. Spin, Philip S. Tsao
Journal: Science Translational Medicine (2012)

miR-21 modulates abdominal aortic aneurysm development by regulating cell proliferation and apoptosis within the aortic wall.
Gene Transfer Into Normal and Atherosclerotic Human Blood Vessels
Authors: Mark D. Rekhter, Robert D. Simari, Carolyn W. Work, Gary J. Nabel, Elizabeth G. Nabel, David Gordon
Journal: Circulation Research (1998)

Gene transfer to blood vessels is a promising new approach to the treatment of the vascular diseases, but the feasibility of gene transfer to adult human vessels has not been explored. We introduced an adenovirus vector encoding a marker gene human placental alkaline phosphatase into normal and atherosclerotic human vessels in organ culture. In the normal vessels, recombinant gene was expressed preferentially in the endothelial cells (approximately 100%), intimal smooth muscle cells (1.3+/-0.4%, 1.4+/-1.0%, and 3.8+/-0.8% in the internal mammary arteries, saphenous veins, and normal coronary arteries, respectively), and various adventitial cells. Advanced, complicated atherosclerotic plaques demonstrated a similar efficiency of recombinant gene expression (3.1+/-0.5% and 3.8+/-0.3% of nonendothelial intimal cells in the coronary artery and carotid artery plaques, respectively). Of these intimal cells, macrophages and smooth muscle cells expressed a transgene, identifying them as targets for gene transfer. Areas of plaque rupture and thrombus are sites of predilection for expression of recombinant genes. Collagenase and elastase treatment increased the percentage of transgenic alkaline phosphatase-positive cells 7 times (P<0.001), suggesting that the pattern of gene expression was affected by the amount of surrounding extracellular matrix. These studies demonstrate the feasibility of gene transfer to human blood vessels. However, these studies also highlight important barriers to adenoviral gene delivery to the actual normal and atherosclerotic human vessels of clinical interest.
Effects of Combined Angiotensin II and Endothelin Receptor Blockade With Developing Heart Failure
Authors: R. Brent New, Angela C. Sampson, Mary K. King, Jennifer W. Hendrick, Mark J. Clair, James H. McElmurray, Jeffrey Mandel, Rupak Mukherjee, None Marc de Gasparo, Francis G. Spinale
Journal: Circulation (2000)

Background —The goal of this study was to determine the comparative effects of angiotensin II type 1 (AT 1 ) receptor inhibition alone, endothelin-1 (ET) receptor blockade alone, and combined receptor blockade on left ventricular (LV) function, contractility, and neurohormonal system activity in a model of congestive heart failure (CHF). Methods and Results —Pigs were randomly assigned to each of 5 groups: (1) rapid atrial pacing (240 bpm) for 3 weeks (n=9), (2) concomitant AT 1 receptor blockade (valsartan, 3 mg/kg per day) and rapid pacing (n=8), (3) concomitant ET receptor blockade (bosentan, 50 mg/kg BID) and rapid pacing (n=8), (4) concomitant combined AT 1 and ET receptor inhibition and rapid pacing (n=8), and (5) sham-operated control (n=9). LV stroke volume was reduced from the control value after rapid pacing, was unchanged with either AT 1 or ET receptor blockade alone, but was improved with combination treatment. LV peak wall stress was reduced in both groups with ET receptor blockade compared with the rapid pacing group. Plasma norepinephrine levels were increased by &gt;3-fold after rapid pacing, remained increased in the monotherapy groups, but were reduced after combination treatment. LV myocyte velocity of shortening was reduced after rapid pacing–induced CHF, remained reduced after AT 1 receptor blockade, increased after ET receptor blockade (compared with rapid pacing–induced CHF values), and returned to within control values after combined blockade. Conclusions —Combined AT 1 and the ET receptor blockade in this model of CHF improved LV pump function, and contributory factors included the effects of LV loading conditions, neurohormonal system activity, and myocardial contractile performance. Thus, combined receptor blockade may provide a useful combinatorial therapeutic approach in CHF.
Squamous cell carcinoma arising within folliculitis decalvans
Authors: L. Yip, A. Ryan, R. Sinclair
Journal: British Journal of Dermatology (2008)

Journal Article Squamous cell carcinoma arising within folliculitis decalvans Get access L. Yip, L. Yip Department of Dermatology, St Vincent's Hospital Melbourne, PO Box 2900, Fitzroy 3065, Victoria, Australia Search for other works by this author on: Oxford Academic Google Scholar A. Ryan, A. Ryan Melbourne Pathology, Victoria, Australia E‐mail: leonaywy@yahoo.co.nz Search for other works by this author on: Oxford Academic Google Scholar R. Sinclair R. Sinclair Department of Dermatology, St Vincent's Hospital Melbourne, PO Box 2900, Fitzroy 3065, Victoria, Australia Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 159, Issue 2, 1 August 2008, Pages 481–482, https://doi.org/10.1111/j.1365-2133.2008.08634.x Published: 01 August 2008
Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia
Authors: J Boultwood, J Perry, A Pellagatti, M Fernandez-Mercado, C Fernandez-Santamaria, M J Calasanz, M J Larrayoz, M Garcia-Delgado, A Giagounidis, L Malcovati, M G Della Porta, M Jädersten, S Killick, E Hellström-Lindberg, M Cazzola, J S Wainscoat
Journal: Leukemia (2010)
Sensitivity, Specificity, Prevalence, and Disease Stage
Authors: John Terrell Redd
Journal: Annals of Internal Medicine (1994)

Letters15 February 1994Sensitivity, Specificity, Prevalence, and Disease StageJohn Terrell Redd, MDJohn Terrell Redd, MDCollege of Physicians and Surgeons, Columbia University; New York, NY 10032Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-4-199402150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:When discussing the new diagnostic tests for sexually transmitted Chlamydia trachomatis infection, Stamm [1] writes that “Although none of these tests is as sensitive or specific as high-quality cultures for chlamydia, all have reasonable sensitivity (70% to 90%) and specificity (96% to 99%) in groups where the prevalence of chlamydial infection exceeds 8% to 10%.” Sensitivity is defined as the percentage of diseased patients who are correctly identified as positive by a test. Specificity is the percentage of disease-free patients who are correctly identified as negative [2]. These test characteristics are not affected by the prevalence of ...References1. Stamm WE. Toward control of sexually transmitted chlamydial infections (Editorial). Ann Intern Med. 1993; 119:432-4. Google Scholar2. Mausner JS, Kramer S. Epidemiology—an introductory text. 2nd ed. Philadelphia: W.B. Saunders Company; 1985:217-23. Google Scholar Author, Article, and Disclosure InformationAuthors: John Terrell Redd, MDAffiliations: College of Physicians and Surgeons, Columbia University; New York, NY 10032 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAcute pancreatitis induced by drugs used in the treatment of solid malignant neoplasms 15 February 1994Volume 120, Issue 4Page: 345KeywordsChlamydiaChlamydia infectionChlamydia trachomatisSexually transmitted diseasesSpecificity ePublished: 15 August 2000 Issue Published: 15 February 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
[775] OVEREXPRESSION OF PIGMENT EPITHELIUM-DERIVED FACTOR PREVENTS FAT STORAGE, INFLAMMATION AND NEOPLASTIC FORMATION IN THE LIVER OF MICE STEATOHEPATITIS MODEL
Authors: T. Yoshida, S. Yamagishi, H. Koga, K. Nakamura, T. Matsui, T. Imaizumi, T. Ueno, M. Sata
Journal: Journal of Hepatology (2007)
Will You Ask? Will They Tell You? Are You Ready to Hear and Respond?
Authors: Bradley O. Boekeloo
Journal: JAMA Pediatrics (2013)

The article by Alexander et al. (201X) titled “Sexuality Talk During Health Maintenance Visits” in this volume addresses physicians' discussion about sexuality with adolescents, and adolescents' responses based on audio-records of 253 adolescent visits with 49 physicians.1 The findings are consistent with other studies indicating low frequency and thoroughness of physician discussion with adolescents about sexuality in primary care.2,3
Metastats: an improved statistical method for analysis of metagenomic data
Authors: Joseph N Paulson, Mihai Pop, Hector Corrada Bravo
Journal: Genome biology (2011)

Deep exome resequencing is a powerful approach for delineating patterns of protein-coding variation among genes, pathways, individuals and populations.We analyzed exome data from 2,440 individuals of European and African ancestry as part of the National Heart, Lung, and Blood Institute's Exome Project, the aim of which is to discover novel genes and mechanisms that contribute to heart, lung and blood disorders.Each exome was sequenced to a mean coverage of 116×, allowing detailed inferences about the population genomic patterns of both common variation and rare coding variation.We identifi ed more than 500,000 single nucleotide variations, the majority of which were novel and rare (76% of variants had a minor allele frequency of less than 0.1%), refl ecting the recent dramatic increase in the size of the human population.The unprecedented magnitude of this dataset allowed us to rigorously characterize the large variation in nucleotide diversity among genes (ranging from 0 to 1.32%), as well as the role of positive and purifying selection in shaping patterns of proteincoding variation and the diff erential signatures of population structure from rare and common variation.This dataset provides a framework for personal genomics and is an important resource that will allow inferences of broad importance to human evolution and health.
Estimating Myocardial Damage and the Need for Surgery in Patients With Valvular Heart Disease by Tl-201 SPECT
Authors: JUNICHI YAMAZAKI, MASAKI IGARASHI, MASAYUKI NAKATA, KIYOSHI OKAMOTO, HIROMITSU HOSOI, TAKESHI MORISHITA, HAJIME NAKANO, YOSHIMASA YABE, KATSUNORI YOSHIWARA, NOBUYA KOYAMA
Journal: Clinical Nuclear Medicine (1996)

Left ventricular myocardial disorders due to volume overload were investigated by Tl-201 myocardial SPECT (Tl-201 SPECT) in patients with aortic or mitral regurgitation, and its utility for timing cardiac valve replacement was studied. There were significant correlations between Tl-201 scores and electrocardiographic changes and the New York Heart Association classification. There also were favorable correlations between Tl-201 scores and the left ventricular end-diastolic dimension and between Tl-201 scores and left ventricular ejection fraction, and a close relationship between the presence of a left ventricular myocardial disorder and left ventricular diameter. These results suggest that myocardial perfusion abnormalities and left ventricular myocardial disorders may accompany left ventricular dilatation owing to volume overload. After valve replacement, left ventricular end-diastolic dimension normalized, and Tl-201 scores improved slightly, suggesting normalization of myocardial perfusion. When moderate or more severe Tl-201 defects are present on Tl-201 SPECT images, in addition to inverted Tl-201 waves on the electrocardiogram or a left ventricular end-diastolic dimension of 65 mm or more, cardiac valve replacement should be considered.
Medicine as a Science: Surgery
Authors: Edward D. Churchill
Journal: New England Journal of Medicine (1951)

ACCORDING to Whitehead, man's faith in a rapid and conscious development of technology was a product of the nineteenth century. He considered this faith sufficiently peculiar to that century to distinguish it from all preceding ones. This same philosopher also viewed the last twenty years of the nineteenth century as one of the "dullest stages of thought since the time of the First Crusade." "The period," he stated, "was efficient, dull, and half-hearted. It celebrated the triumph of the professional man."It happens that what is commonly referred to as "modern" surgery came into being during these twenty years, for . . .
Outcome of Out-of-Hospital Cardiac or Respiratory Arrest in Children
Authors: Margrid B. Schindler, Desmond Bohn, Peter N. Cox, Brian W. McCrindle, Anna Jarvis, John Edmonds, Geoffrey Barker
Journal: New England Journal of Medicine (1996)

Among adults who have a cardiac arrest outside the hospital, the survival rate is known to be poor. However, less information is available on out-of-hospital cardiac arrest among children. This study was performed to determine the survival rate among children after out-of-hospital cardiac arrest and to identify predictors of survival.
Egr-2 prevents self-reactions
Authors: Hema Bashyam
Journal: The Journal of Experimental Medicine (2008)

![Graphic][1] 

Overproliferating T cells infiltrate the liver and trigger lupus-like autoimmunity in older Egr-2–deficient mice. Self-tolerance is well known to be enforced in part by an external force of regulatory T cells. Now, Zhu et al. (page 

[2295][2]) show that T cells also
Abstract LB-78: Detection of circulating cell-free DNA is enhanced by targeting short fragments: high concordance of the <i>KRAS</i> and <i>BRAF</i> mutation status from plasma analysis, with tumor-tissue analysis in colorectal cancer..
Authors: Florent Mouliere, Dalong Pang, Safia El Messaoudi, Denis Pezet, Muriel Mathonnet, Marc Ychou, Anatoly Dritschilo, Alain R. Thierry
Journal: Cancer Research (2013)

Abstract We investigated size distributions of circulating cell-free DNA (ccfDNA) to determine its value as a potential theranostic tool. CcfDNA quantification by Q-PCR was optimal when amplifying target lengths between 60 and 100 bp. CcfDNA sizes were previously believed to be greater than the length of the DNA per nucleosome (~180 bp). Q-PCR analyses of plasma samples from xenografted mice and from colorectal cancer (CRC) patients showed that tumor derived ccfDNA exhibited specific profiles of ccfDNA sizes with significantly higher ccfDNA fragmentation than was observed in samples from healthy individuals. Atomic Force Microscopy analysis confirmed these observations and, for the first time, enables visual representation of ccfDNA molecules. CcfDNA from plasma of CRC patients exhibited a median size of 135 bp and 88% of ccfDNAs are less than 180 bp in size. Based on these observations, we developed a refined single-step Allele Specific Q-PCR based method (Intplex) with improved specificity and sensitivity for enabling single-copy detection of variant alleles to a sensitivity of ≥ 0.005% mutant to WT ratio. We performed a blinded prospective study to compare KRAS and BRAF mutation status data by analysis of tumor tissue of CRC patients by standard methods and of plasma DNA (n=79). CcfDNA analysis showed 100% specificity and sensitivity for the BRAF V600E mutation. For the six tested KRAS point mutations, the method exhibited 100% specificity and 87% sensitivity with a concordance value of 96%. Mutation load expressed as the proportion of mutant alleles in ccfDNA, was highly variable (0.03% to 69%, median, 10.9%; n=128) and was determined in the plasma of every patient at stage I, II, III and IV (100% success rate). Tumor-derived ccfDNA did not correspond to "a tiny fraction" as it has been previously stated and it is likely not derived mainly from stroma cells. CcfDNA analysis could replace advantageously tumor-section analysis for determining KRAS and BRAF mutation status and expand the scope of personalized medicine for cancer patients. Citation Format: Florent Mouliere, Dalong Pang, Safia El Messaoudi, Denis Pezet, Muriel Mathonnet, Marc Ychou, Anatoly Dritschilo, Alain R. Thierry. Detection of circulating cell-free DNA is enhanced by targeting short fragments: high concordance of the KRAS and BRAF mutation status from plasma analysis, with tumor-tissue analysis in colorectal cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-78. doi:10.1158/1538-7445.AM2013-LB-78
The Opium Question in the Philippines.
Authors: E. C. Carter
Journal: JAMA (1905)

Manila, April 14, 1905. <h3>To the Editor:</h3> —In connection with the editorial in the<i>Medical Review</i>Dec. 10, 1904, on the above question the following statements may be worthy of consideration: It is to be regretted that the report of the committee appointed to investigate the use of opium and matters therewith connected has not been published, as an acquaintance with its contents might lead to an avoidance of inaccurate statements in regard to its purport. But as the report is voluminous, containing not only the findings, conclusions and recommendations of the committee, but also all the evidence, statistics and laws on which they are based, it is still in the hands of the printer. The report will stand or fall on its own intrinsic merit, and should be read, if a sufficiently patient reader may be found, before the final word of criticism or commendation is said. Until the