tbuckley/cabot-search huggingface dataset:
Narcotics Control in Anesthesia Training
Authors: Gerald R. Adler
Journal: JAMA (1985)

Recent studies document that substance abuse is a significant problem among anesthesia personnel. We have developed a system to better control the accountability of narcotics and other potentially addictive drugs. The system consists of a three-phase approach: (1) an individual anesthesia cart/narcotics box; (2) computer analysis of drug usage; and (3) an anesthesia drug audit. A standard stock issue of drugs is maintained by each resident. Drugs are issued daily to those residents administering anesthesia. Each drug transaction is recorded by the resident according to the patient's name, hospital number, type and length of the surgical procedure, type and amount of drug used, and the amount of each drug discarded. A weekly computer-generated report shows individual usage trends for each drug and a summary of "high" users for that period. The computer does not "flag" an individual as a drug abuser, but monitors trends in controlled substance usage. Those residents having a significant alteration in their drug usage pattern that is not explained legitimately are comprehensively audited.
Mechanisms of post-intervention arterial remodelling
Authors: S. A. Goel, L.-W. Guo, B. Liu, K. C. Kent
Journal: Cardiovascular Research (2012)

It has been appreciated over the past two decades that arterial remodelling, in addition to intimal hyperplasia, contributes significantly to the degree of restenosis that develops following revascularization procedures. Remodelling appears to be an adventitia-based process that is contributed to by multiple factors including cytokines and growth factors that regulate extracellular matrix or phenotypic transformation of vascular cells including myofibroblasts. In this review, we summarize the currently available information from animal models as well as clinical investigations regarding arterial remodelling. The factors that contribute to this process are presented with an emphasis on potential therapeutic methods to enhance favourable remodelling and prevent restenosis.
The Duhring chamber assay for corticosteroid atrophy
Authors: PETER J.FROSCH, EVA-MARIA BEHRENBECK, KELLY FROSCH, EGON MACHER
Journal: British Journal of Dermatology (1981)

A new human model for the evaluation of the atrophogenicity of topical corticosteroids is proposed. Formulated corticosteroids (creams and ointments) were applied occlusively to normal forearm skin of human volunteers for 3 weeks using Duhring chambers. Visible atrophy and telangiectasia were rated under a stereomicroscope on a histologically validated five-point scale. There was a close correlation between the parameters of atrophy and telangiectasia. Atrophogenicity varied considerably among the tested corticosteroids, ranging from none (1% hydrocortisone) via moderate (0.1% betamethasone valerate) to very severe (0.05% clobetasol propionate). A dose-response relationship with exposure time and concentration of the corticosteroid could be demonstrated. Furthermore, the vehicle influenced the resulting atrophy and telangiectasia. Fatty ointments seem to pose less risk than oil in water creams.
Altered Biodistribution of Tc-99m MDP in a Uremic and Severely Malnourished Patient Supported With Enteral Nutritional Feeding
Authors: NURI ARSLAN, SEYFETTIN ILGAN, ALPER OZGUR KARACALIOGLU, EMEL OZTURK, HIKMET BAYHAN
Journal: Clinical Nuclear Medicine (1999)

A 25-year-old man with stage IV anaplastic nasopharynx carcinoma had a bone scan with Tc-99m MDP, which did not reveal any bone metastases. However, significant tracer uptake was observed in both lungs, myocardium, stomach, and thyroid, possibly secondary to uremia and severe malnutrition.
High glucose levels inhibit focal adhesion kinase-mediated wound healing of rat peritoneal mesothelial cells
Authors: Masahito Tamura, Akihiko Osajima, Shingo Nakayamada, Hirofumi Anai, Narutoshi Kabashima, Kaori Kanegae, Takayuki Ota, Yoshiya Tanaka, Yasuhide Nakashima
Journal: Kidney International (2003)
Chromosomal Mapping of Quantitative Trait Loci That Influence Renal Hemodynamic Functions
Authors: Naoharu Iwai, Masahiko Kinoshita, Hitoshi Shimoike
Journal: Circulation (1999)

Impaired renal hemodynamic function has been suspected to be responsible for hypertension in the spontaneously hypertensive rat (SHR).We measured renal hemodynamic functions, including the glomerular filtration rate, renal plasma flow, and renal vascular resistance, in an F2 rat population derived from spontaneously hypertensive and Wistar-Kyoto (WKY) rats and performed a genome-wide screening to map quantitative trait loci that influence these functions to gain insight into the relationship between renal hemodynamic functions and blood pressure control. The D1 Mit7 locus was identified as a major locus that influenced renal hemodynamic functions, and we transferred the SHR chromosomal segment around the D1 Mit7 locus into the WKY strain. The congenic rats exhibited impaired renal hemodynamic functions. The systolic blood pressure of the congenic rats was significantly higher than that of age-matched WKY rats, but only at nighttime. No significant differences in systolic blood pressure during daytime or diastolic blood pressure were observed between the 2 strains.We have identified a chromosome segment that influences renal hemodynamic function. The SHR chromosome segment around the D1 Mit7 locus had significant, but not dramatic, effects in increasing blood pressure in the WKY genetic background. However, further studies will be necessary to determine the significance of this locus in SHR hypertension.
Sweet's syndrome in Crohn's disease.
Authors: D. Kemmett, D. J. Gawkrodger, G. Wilson, J. A. Hunter
Journal: BMJ (1988)

Deux observations rares: femmes presentant un syndrome de Sweet lors d'exacerbations de maladie de Crohn au niveau du colon. Dans les 2 cas le traitement par prednisolone est efficace contre l'affection cutanee
Epigenetic-Mediated Dysfunction of the Bone Morphogenetic Protein Pathway Inhibits Differentiation of Glioblastoma-Initiating Cells
Authors: Jeongwu Lee, Myung Jin Son, Kevin Woolard, Nicholas M. Donin, Aiguo Li, Chui H. Cheng, Svetlana Kotliarova, Yuri Kotliarov, Jennifer Walling, Susie Ahn, Misuk Kim, Mariam Totonchy, Thomas Cusack, Chibawanye Ene, Hilary Ma, Qin Su, Jean Claude Zenklusen, Wei Zhang, Dragan Maric, Howard A. Fine
Journal: Cancer Cell (2008)
A History of the Royal College of Physicians of London, volume four (1948-1983)
Authors: Roger Cooter
Journal: BMJ (2005)

I f ever there was a candidate for the dustbin of history at the outset of the NHS in 1948 it was the Royal College of Physicians of London. By then (the starting point for this fourth volume of its history) it had long outlived its initial guild conception. Nor was it an educational college in the modern sense, or a pressure group, or a specialty body, or a professionals' trade union. Renowned for its disdain of general practitioners as much as for its distrust of laboratory medicine, this 430 year old relic of medical elitism was ill fitted to the democratised new healthcare system—cordial and profitable though the negotiations had been between its then president, Lord Moran, and NHS architect Nye Bevan. Essentially a gentleman's club with a well stocked cellar, it was tucked away in a building at the corner of Trafalgar Square and Pall Mall East (better known then and now as Canada House)—its home since 1825. It was without a medical or a college secretary, and there was scarcely a woman to be found among its 767 fellows.

Asa Briggs

Oxford University Press, £60, pp 498 ISBN 0 19 925334 X …
Control of Splicing Efficiency by the Mouse Histone H2a Element in a Murine Leukemia Virus–based Retroviral Vector
Authors: Jun-Tae Lee, Seung Shin Yu, V Narry Kim, Sunyoung Kim
Journal: Molecular Therapy (2006)

While using various human complementary DNA (cDNA) sequences in the context of the murine leukemia virus (MLV)–based retroviral vector, it was found that a retroviral vector containing some human cDNA sequences produces unusually low viral titer. One of those sequences is that for the human IL-1 receptor antagonist protein (IL1RN). The RNA analysis showed that a cryptic splice acceptor sequence is present in the middle of its coding region, resulting in the deletion of the packaging signal sequence and the removal of some coding sequences that lead to low viral titer and a low level of the transgene product. We tested whether the mouse Hist2h2aa1 element (mH2aE), previously shown to suppress the splicing function, could inhibit the cryptic splicing in the context of MLV-based retroviral vectors. It was found that the mH2aE could efficiently suppress such unwanted splicing event, thus increasing the amount of unspliced transcript, which eventually led to the increase in the level of IL1RN expression and viral titer. The mH2aE could also be used to control unusually high splicing activity. Our data suggested that the mH2aE could be used for the fine-tuning of the splicing process, thus improving the level of gene expression and viral titer in the context of retroviral vectors. While using various human complementary DNA (cDNA) sequences in the context of the murine leukemia virus (MLV)–based retroviral vector, it was found that a retroviral vector containing some human cDNA sequences produces unusually low viral titer. One of those sequences is that for the human IL-1 receptor antagonist protein (IL1RN). The RNA analysis showed that a cryptic splice acceptor sequence is present in the middle of its coding region, resulting in the deletion of the packaging signal sequence and the removal of some coding sequences that lead to low viral titer and a low level of the transgene product. We tested whether the mouse Hist2h2aa1 element (mH2aE), previously shown to suppress the splicing function, could inhibit the cryptic splicing in the context of MLV-based retroviral vectors. It was found that the mH2aE could efficiently suppress such unwanted splicing event, thus increasing the amount of unspliced transcript, which eventually led to the increase in the level of IL1RN expression and viral titer. The mH2aE could also be used to control unusually high splicing activity. Our data suggested that the mH2aE could be used for the fine-tuning of the splicing process, thus improving the level of gene expression and viral titer in the context of retroviral vectors.
Ascending aortic false aneurysm following cannulation for perfusion.
Authors: B Branchini, B Zingone, M Vaccari
Journal: Thorax (1976)

<h3>Summary</h3> LY-CoV1404 is a highly potent, neutralizing, SARS-CoV-2 spike glycoprotein receptor binding domain (RBD)-specific antibody identified from a convalescent COVID-19 patient approximately 60 days after symptom onset. In pseudovirus studies, LY-CoV1404 retains potent neutralizing activity against numerous variants including B.1.1.7, B.1.351, B.1.427/B.1.429, P.1, and B.1.526 and binds to these variants in the presence of their underlying RBD mutations (which include K417N, L452R, E484K, and N501Y). LY-CoV1404 also neutralizes authentic SARS-CoV-2 in two different assays against multiple isolates. The RBD positions comprising the LY-CoV1404 epitope are highly conserved, with the exception of N439 and N501; notably the binding and neutralizing activity of LY-CoV1404 is unaffected by the most common mutations at these positions (N439K and N501Y). The breadth of variant binding, potent neutralizing activity and the relatively conserved epitope suggest that LY-CoV1404 is one in a panel of well-characterized, clinically developable antibodies that could be deployed rapidly to address current and emerging variants. New variant-resistant treatments such as LY-CoV1404 are desperately needed, given that some of the existing therapeutic antibodies are less effective or ineffective against certain variants and the impact of variants on vaccine efficacy is still poorly understood. <h3>In Brief</h3> LY-CoV1404 is a potent SARS-CoV-2-binding antibody that neutralizes all known variants of concern and whose epitope is rarely mutated. <h3>Highlights</h3> LY-CoV1404 potently neutralizes SARS-CoV-2 authentic virus and all known variants of concern No loss of potency against current variants Binding epitope on RBD of SARS-CoV-2 is rarely mutated in GISAID database Breadth of neutralizing activity and potency supports clinical development
Current status of percutaneous coronary intervention: Results from a large international trial
Authors: Heidar Arjomand, James T. Willerson, David R. Holmes, Prem Kittusamy, Satish Surabhi, Bassam Roukoz, Andrey Espinoza, Daniel McCormick, Zoltan G. Turi, Sheldon Goldberg
Journal: Journal of the American College of Cardiology (2003)
A Field Guide to Germs
Authors: Moses Grossman
Journal: JAMA (1996)

Wayne Biddle, a well-known reporter in the fields of science and technology, has published his third book,<i>A Field Guide to Germs</i>. He uses the term<i>germ</i>rather broadly. After a longish introduction, all the subjects are arranged alphabetically. They include the most important causative agents of disease—viral, bacterial, protozoal, and so on. Most are listed by the name of the agent, others by the name of the disease, eg, typhoid and typhus. A few entries have little to do with conventional germs, and their inclusion is surprising. One finds a short paragraph called "Bites" and another called "Chinese Restaurant Syndrome." The germ connection of the latter is that monosodium glutamate is manufactured by<i>Corynebacterium glutamicum</i>. Seventy subjects are dealt with in all, from adenovirus to Zika fever. It is clear that the author is particularly interested in historical aspects of the colorful epidemic diseases. Smallpox, cholera, plague, and yellow
Flavopiridol can be safely administered using a pharmacologically derived schedule and demonstrates activity in relapsed and refractory non‐Hodgkin's lymphoma
Authors: Jeffrey A. Jones, Amy S. Rupert, Ming Poi, Mitch A. Phelps, Leslie Andritsos, Robert Baiocchi, Don M. Benson, Kristie A. Blum, Beth Christian, Joseph Flynn, Sam Penza, Pierluigi Porcu, Michael R. Grever, John C. Byrd
Journal: American Journal of Hematology (2013)

Flavopiridol is a broad cyclin-dependent kinase inhibitor (CDKI) that induces apoptosis of malignant lymphocytes in vitro and in murine lymphoma models. We conducted a Phase I dose-escalation study to determine the maximum tolerated dose (MTD) for single-agent flavopiridol administered on a pharmacokinetically derived hybrid dosing schedule to patients with relapsed and refractory non-Hodgkin's lymphoma. Dose was escalated independently in one of four cohorts: indolent B-cell (Cohort 1), mantle cell (Cohort 2), intermediate-grade B-cell including transformed lymphoma (Cohort 3), and T-/NK-cell excluding primary cutaneous disease (Cohort 4). Forty-six patients were accrued. Grade 3 or 4 leukopenia was observed in the majority of patients (60%), but infection was infrequent. Common nonhematologic toxicities included diarrhea and fatigue. Biochemical tumor lysis was observed in only two patients, and no patients required hemodialysis for its management. Dose escalation was completed in two cohorts (indolent and aggressive B-cell). Dose-limiting toxicities were not observed, and the MTD was not reached in either cohort at the highest dose tested (50 mg/m(2) bolus + 50 mg/m(2) continuous infusion weekly for 4 consecutive weeks of a 6-week cycle). Clinical benefit was observed in 26% of 43 patients evaluable for response, including 14% with partial responses (two mantle cells, three indolent B-cells, and one diffuse large B-cell). The single-agent activity of this first-generation CDKI suggests that other agents in this class merit further study in lymphoid malignancies, both alone and in combination.
Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer
Authors: Raul Alba, Angela C. Bradshaw, Alan L. Parker, David Bhella, Simon N. Waddington, Stuart A. Nicklin, Nico van Rooijen, Jerome Custers, Jaap Goudsmit, Dan H. Barouch, John H. McVey, Andrew H. Baker
Journal: Blood (2009)
The Treatment of Drug Addiction
Authors: Victor H. Vogel
Journal: JAMA (1965)

<h3>To the Editor:—</h3> The treatment of diacetylmorphine (heroin) addiction by methadone (<b>193</b>:646, 1965) does not come up to expectations generated by prior publicity in the public press and two feature articles in the<i>New Yorker</i>. Dole and Nyswander seem to be unaware of the tragic consequences of heroin as a cure for morphine addiction introduced at the turn of the century, and the later use of meperidine (Demerol) as a harmless narcotic. Although stated to be only a progress report, an unwarranted conclusion is made, "Maintenance of patients with methadone is no more difficult than maintaining diabetics with oral hypoglycemic agents, and in both cases the patient should be able to live a normal life." The problem of treating the methadone addiction is not mentioned. Although 22 cases are presented as evidence of success of the treatment, two had been followed less than one month and ten cases for
HSV-1 Amplicon Vectors Launch the Production of Heterologous Rotavirus-like Particles and Induce Rotavirus-specific Immune Responses in Mice
Authors: Andrea S Laimbacher, Laura E Esteban, Alejandro A Castello, Juan C Abdusetir Cerfoglio, Marcelo H Argüelles, Graciela Glikmann, Alejandra D'Antuono, Nora Mattion, Mabel Berois, Juan Arbiza, Monika Hilbe, Elisabeth M Schraner, Michael Seyffert, Christiane Dresch, Alberto L Epstein, Mathias Ackermann, Cornel Fraefel
Journal: Molecular Therapy (2012)

Virus-like particles (VLPs) are promising vaccine candidates because they represent viral antigens in the authentic conformation of the virion and are therefore readily recognized by the immune system. As VLPs do not contain genetic material they are safer than attenuated virus vaccines. In this study, herpes simplex virus type 1 (HSV-1) amplicon vectors were constructed to coexpress the rotavirus (RV) structural genes VP2, VP6, and VP7 and were used as platforms to launch the production of RV-like particles (RVLPs) in vector-infected mammalian cells. Despite the observed splicing of VP6 RNA, full-length VP6 protein and RVLPs were efficiently produced. Intramuscular injection of mice with the amplicon vectors as a two-dose regimen without adjuvants resulted in RV-specific humoral immune responses and, most importantly, immunized mice were partially protected at the mucosal level from challenge with live wild-type (wt) RV. This work provides proof of principle for the application of HSV-1 amplicon vectors that mediate the efficient production of heterologous VLPs as genetic vaccines. Virus-like particles (VLPs) are promising vaccine candidates because they represent viral antigens in the authentic conformation of the virion and are therefore readily recognized by the immune system. As VLPs do not contain genetic material they are safer than attenuated virus vaccines. In this study, herpes simplex virus type 1 (HSV-1) amplicon vectors were constructed to coexpress the rotavirus (RV) structural genes VP2, VP6, and VP7 and were used as platforms to launch the production of RV-like particles (RVLPs) in vector-infected mammalian cells. Despite the observed splicing of VP6 RNA, full-length VP6 protein and RVLPs were efficiently produced. Intramuscular injection of mice with the amplicon vectors as a two-dose regimen without adjuvants resulted in RV-specific humoral immune responses and, most importantly, immunized mice were partially protected at the mucosal level from challenge with live wild-type (wt) RV. This work provides proof of principle for the application of HSV-1 amplicon vectors that mediate the efficient production of heterologous VLPs as genetic vaccines.
Study of aeroball injuries.
Authors: A Sinha, R G McGlone, K Montgomery
Journal: British Journal of Sports Medicine (1997)

To present the risks of aeroball, a new sport played by either two or four players on a trampoline court surrounded by specially constructed fabric walls, and to propose ways to increase awareness and reduce the incidence of injury, in particular, ankle injury.A study was carried out to document the nature of aeroball related incidents, between 1991 and 1995, at Lancaster University Sports Centre. Lace-up ankle supports were introduced in April 1992, and their effect on the incidence of ankle injury was recorded.The lower limb received most injuries (90%), followed by the upper limb (6%), then the face (3%) and cervical spine (1%). The most common category of injuries was sprains (83%), followed by fractures (8%), contusions (5%), and dislocations (4%). The most common site of injury was the ankle (73%). It is during doubles play that injury is most likely to occur. Since the introduction of ankle supports, there has been a gradual decline in the incidence of ankle injury, 31 in 1991 to nine in 1995.Aeroball has become a popular sport, but it is not without risks. Leaflets have been produced to promote the objectives, rules, and safety of the game. Trained full-time staff should be present to explain the nature of the game. The use of prophylactic ankle stabilisers in aeroball is strongly recommended.
Use of Chlorpromazine and Reserpine in Mental Disorders
Authors: Mark D. Altschule
Journal: New England Journal of Medicine (1956)

THE last three or four decades have seen great progress in the treatment of mental disease by physical means. Syphilis of the brain and pellagra, both of which were formerly responsible for many admissions to mental hospitals, are no longer serious problems in America, owing to the development of specific cures for them. Insulin and electroshock have been useful in the treatment of manic-depressive and, to a lesser extent, schizophrenic psychoses. Hormones also have been helpful in patients with depressions1 or with post-partum psychoses.2 A few years ago two chemical agents, chlorpromazine and reserpine, were introduced; they have already changed . . .
Abstract 2987: A critical role of translocated promoter region (Tpr) in chromosome segregation and cell division in cancer
Authors: Tatsuyoshi Funasaka, Hiroshi Nakano, Richard Wong
Journal: Cancer Research (2011)

Abstract Cancer cells accumulate the many genetic abnormalities required for cancer development. Abnormal chromosome is often observed in cancer cells and is thought to be due to chromosome segregation errors during mitosis. In eukaryotic cells, the faithful segregation of daughter chromosomes during cell division depends on formation of a microtubule-based bipolar spindle apparatus. Nuclear pore complexes are massive multiprotein channels responsible for traffic between the nucleus and cytoplasm, and are composed of approximately 30 proteins termed nucleoporins. Several components of the nuclear pore complex/nucleoporins play critical roles in orchestrating the rapid remodeling events that occur during mitosis. Our recent studies revealed that the nucleoporin, Rae1, plays critical roles in maintaining spindle bipolarity. Here, we show association of another nucleoporin, termed Tpr (translocated promoter region), with the molecular motors dynein and dynactin, which both orchestrate with the spindle checkpoints Mad1 and Mad2 during cell division. Overexpression of Tpr enhanced multinucleated cell formation. RNA interference-mediated knockdown of Tpr caused a severe lagging chromosome phenotype and disrupted spindle checkpoint proteins expression and localization. Next, we performed a series of rescue and dominant negative experiments to confirm that Tpr orchestrates proper chromosome segregation through interaction with dynein light chain. Our data indicate that Tpr functions as a spatial and temporal regulator of spindle checkpoints, ensuring the efficient recruitment of checkpoint proteins to the molecular motor dynein to promote proper anaphase formation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2987. doi:10.1158/1538-7445.AM2011-2987