tbuckley/cabot-search huggingface dataset:
Differentiation of intrahepatic peribiliary glands and pancreatic acinar cells from the remodeling ductal plate in human fetuses
Authors: Tadashi Terada
Journal: Hepatology (2012)

In a recent article published in Gastroenterology, Carpentier et al.1 suggested that embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells. Herein, the authors demonstrated that the ductal plate also gives rise to pancreatic acinar cells and intrahepatic peribiliary glands.2 The authors previously reported that clusters of pancreatic acinar cells are present in normal adult livers.3 The ductal plate is a double-layered cylindrical structure located in the periportal regions of the fetal liver (Fig. 1A).4-8 The ductal plate undergoes remodeling (Fig. 1B,C), leading to the normal cholangiocytes and intrahepatic peribiliary glands.4-8 The remodeling involves apoptosis and cell proliferation of the ductal plate. Several molecules, such as glycoconjugates, Levis y, Bcl-2, C-myc, tenascin, matrix metalloproteinases, tissue inhibitors of matrix metalloproteinases, trypsin, pancreatic digestive enzymes, E-cadherin, and catenin, are involved in the process of ductal plate remodeling.2-10 Pancreatic acinar cell clusters develop from the remodeling ductal plate.4, 8 The authors again reviewed 42 fetal livers of various gestational ages and 32 postnatal livers, and observed that intrahepatic peribiliary glands developed from the remodeling ductal plate at 35 to 40 gestational weeks for fetal livers as well as in the infant livers. The authors also found that pancreatic acinar cells developed from remodeling and remodeled ductal plate at 38 to 40 gestational weeks for fetal livers (Fig. 1D) as well as infant livers of 1 to 3 months (Fig. 1E). Immunohistochemically, the pancreatic acinar cells contained pancreatic amylase, trypsinogen, and lipase. The development of intrahepatic bile ducts. (A) The ductal plate at 12 gestational weeks. Cytokeratin immunostaining, ×100. (B) Remodeling or remodeled ductal plate at 18 gestational weeks. Cytokeratin immunostaining, ×100. (C) The remodeling ductal plate (arrow) at 17 gestational weeks. The cells of the ductal plate invade into the portal mesenchyma (arrow). Hematoxylin and eosin, ×200. (D) The development of pancreatic acinar cells (arrow) at 39 gestational weeks. Hematoxylin and eosin, ×50. (E) Pancreatic acinar cells (arrow) develop from the remodeled ductal plate in a 2-month-old infant liver. Hematoxylin and eosin, ×200. Tadashi Terada M.D., Ph.D.*, * Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan.
Expression of odontogenic ameloblast‐associated and amelotin proteins in the junctional epithelium
Authors: Clarice Nishio, Rima Wazen, Pierre Moffatt, Antonio Nanci
Journal: Periodontology 2000 (2013)

Abstract Two novel proteins – odontogenic ameloblast‐associated protein and amelotin – have recently been identified in maturation‐stage ameloblasts and in the junctional epithelium. This article reviews the structure and function of the junctional epithelium, the pattern of expression of odontogenic ameloblast‐associated and amelotin proteins and the potential involvement of these proteins in the formation and regeneration of the junctional epithelium.
Public Attitudes About Abortion
Authors: Raymond J. Adamek
Journal: JAMA (1994)

<h3>To the Editor.</h3> —In their abortion poll review, Dr Blendon and colleagues<sup>1</sup>addressed four issues. Regarding the second issue, "public perspectives on the desired legality of abortion," they failed to observe their own criterion of omitting biased questions, neglected to answer fully the question of how the Table data "relate to public attitudes about sustaining<i>Roe v Wade</i>," and failed to note important conclusions. Although warning us that poll questions referring only to the first-trimester aspects of<i>Roe v Wade</i>may be biased, Blendon et al analyze responses to such a question in detail, the question posed by Harris, which is triply biased in a pro-choice direction.<sup>2,3</sup>Its main fault is that it gives the respondent uninformed about the content of<i>Roe v Wade</i>the impression that the court legalized abortion only in the first trimester, and seeks the informed respondent's opinion only on the first-trimester ruling. Yet
Apixaban reduced stroke or systemic embolism in AF more than warfarin regardless of type or duration of AF
Authors: Sara Vazquez, Matthew T. Rondina
Journal: Annals of Internal Medicine (2013)

Source Citation Al-Khatib SM, Thomas L, Wallentin L, et al. Outcomes of apixaban vs. warfarin by type and duration of atrial fibrillation: results from the ARISTOTLE trial. Eur Heart J. 2013 Apr 17. [Epub ahead of print]. 23594592
564 LIVER RELATED EVENTS (LRE) IN PATIENTS WITH ESTABLISHED HCV RECURRENT DISEASE AFTER LIVER TRANSPLANTATION COULD BE PREDICTED BY LIVER STIFFNESS MEASUREMENT (LSM)
Authors: M. Rendina, N.M. Castellaneta, Z. Marianna, R.S. Bringiotti, L. Lupo, F. Rizzi, S. Barbalinardo, A. Francavilla, A. Di Leo
Journal: Journal of Hepatology (2011)
VENOUS CONGESTION OF THE EXTREMITIES IN RELATION TO BLOOD VOLUME DETERMINATIONS AND TO MIXING CURVES OF CARBON MONOXIDE AND T-1824 IN NORMAL HUMAN SUBJECTS 1
Authors: Ellen Brown, James Hopper, John J. Sampson, Charles Mudrick
Journal: Journal of Clinical Investigation (1951)

Investigations of circulatory problems often in- volve measurement of the blood volume in clinical conditions which may be characterized by im- portant grades of stasis or venous congestion.such as pregnancy, heart failure, and shock.
INCREASED INSULIN SENSITIVITY IN ADVANCED HEART FAILURE PATIENTS TREATED WITH LEFT VENTRICULAR ASSIST DEVICE
Authors: Nir Uriel, Sang-Woo Pak, Paolo Colombo, Vlad Cotarlan, Maryjane Farr, Donna Mancini, Yoshifumi Naka, Yoshifumi Naka, Ulrich P. Jorde
Journal: Journal of the American College of Cardiology (2010)
NR3A-containing NMDARs promote neurotransmitter release and spike timing–dependent plasticity
Authors: Rylan S Larsen, Rebekah J Corlew, Maile A Henson, Adam C Roberts, Masayoshi Mishina, Masahiko Watanabe, Stuart A Lipton, Nobuki Nakanishi, Isabel Pérez-Otaño, Richard J Weinberg, Benjamin D Philpot
Journal: Nature Neuroscience (2011)
Electrophysiologic effects of adenosine-5'-triphosphate on atrioventricular reentrant tachycardia.
Authors: B Belhassen, A Pelleg, D Shoshani, B Geva, S Laniado
Journal: Circulation (1983)

The effects of adenosine-5'-triphosphate (ATP) on atrioventricular reentrant tachycar- dia (AVRT) were studied in 18 patients.Nine patients had AV nodal reentrant tachycardia and the remaining nine patients had AVRT with an accessory pathway for retrograde conduction.After electrophysiologic control study, ATP was administered (20 mg iv, rapid bolus) during sustained tachycardia and during right ventricular pacing (150 beats/min).ATP terminated the tachycardia within 16 sec of administration in eight of nine patients with AV nodal reentry and in all patients with accessory pathways.Termination of the tachycardia was related to a block in the antegrade slow pathway in patients with AV nodal reentry and to a block in the AV node in patients with accessory pathways.In one patient with AV nodal reentry, ATP resulted in a slowdown of the rate of the tachycardia due to delayed conduction in the slow antegrade pathway.No change in the conduction in the retrograde fast nodal pathway or in the accessory pathway was noted in any patient before termination of the tachycardia.The administration of ATP during ventricular pacing resulted in transient complete ventriculoatrial (VA) block or slight prolongation of VA conduction in five of nine patients with AV nodal reentry.VA conduction was not affected in four of nine patients with AV nodal reentry nor in all patients with accessory pathways.Short-lived and benign side effects were commonly noted after administration of ATP.Transient episodes of second-degree or complete AV block and sinus bradycardia were noted in eight patients and did not require any treatment.These results suggest that intravenous ATP is a safe and effective drug for rapid termination of AVRT.
Health-related utility among adults with atopic dermatitis treated with 0·1% tacrolimus ointment as maintenance therapy over the long term: findings from the Protopic<sup>®</sup>CONTROL study
Authors: C.D. Poole, C. Chambers, M.K. Sidhu, C.J. Currie
Journal: British Journal of Dermatology (2009)

Long-term maintenance treatment with 0.1% tacrolimus ointment for the prevention of flares has been demonstrated to be well tolerated and effective in adults for the treatment of atopic dermatitis (AD) but its impact on health-related utility has not been reported.The purpose of this study was to estimate utility changes associated with the use of tacrolimus ointment in the maintenance treatment of adults with AD.Data were collected from a clinical trial investigating long-term maintenance treatment with 0.1% tacrolimus ointment in adults with AD. All patients were treated with twice-daily tacrolimus ointment during an open-label period (OLP) of up to 6 weeks, with subsequent randomization to a double-blind disease-control period (DCP) of 12 months comparing tacrolimus ointment, used twice weekly as maintenance treatment, vs. the emollient vehicle as standard treatment. Health-related utility (EQ-5D(index)) was estimated by Monte Carlo simulation from SF-12 responses by application of a published response mapping algorithm and the U.K. tariff for EQ-5D responses and SF-6D responses, respectively.Evaluable data were available for 257 patients stratified into mild, moderate or severe AD with a median age at screening of 28 years [interquartile range (IQR) 22-38] and 40% male. At screening the median EQ-5D(index) across the strata was 0.848 units (IQR 0.704-0.882) for mild cases, 0.796 (0.737-0.876) for moderate cases, and 0.760 (0.661-0.823, P < 0.001) for those with severe disease. At the end of the OLP, mean utility improvement across all strata was 0.027 [95% confidence interval (CI) -0.011 to 0.065, P = 0.165] for mild cases, 0.046 (95% CI 0.015-0.064, P = 0.002) for moderate cases and 0.076 (95% CI 0.035-0.118, P < 0.001) for those with severe disease. At the end of the blinded DCP, repeated measures analysis showed an age- and sex-adjusted mean change of 0.045 units (P < 0.001) for subjects treated with tacrolimus ointment over those treated with emollient vehicle.Patients with AD of all severities showed considerable decrements in health-related utility. However, treatment with 0.1% tacrolimus ointment was associated with clinically significant improvement in health-related utility for patients with moderate and severe AD, which was sustained over a 12-month maintenance period compared with those using standard treatment with an emollient vehicle.
Medical Men Who Have Attained Fame in Other Fields of Endeavor
Authors: ERNEST WEINFIELD
Journal: Annals of Internal Medicine (1930)

Article1 April 1930Medical Men Who Have Attained Fame in Other Fields of EndeavorI. Medical Men as MusiciansERNEST WEINFIELD, B.S., M.D.ERNEST WEINFIELD, B.S., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-10-1046 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOne of the most splendid tributes to the medical profession was paid by R. L. Stevenson, who in the dedication of "Underwoods" said, "There are men and classes of men that stand above the common herd; the soldier, the sailor, and the shepherd not infrequently; the artist rarely, more rarely still the clergyman; the physician almost as a rule. He is the flower (such as it is) of our civilization; and when that stage of man is done with, and only remembered to be marveled at in history, he will be thought to have shared as little as any in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProfessor Bernhard Pollack (18651928) of Friedrich Wilhelm University, Berlin: Neurohistologist, Ophthalmologist, Pianist 1 April 1930Volume 3, Issue 10Page: 1046-1054KeywordsArmed forces Issue Published: 1 April 1930 PDF downloadLoading ...
Bone marrow aspiration, biopsy, and culture in the evaluation of HIV‐infected patients for invasive mycobacteria and histoplasma infections
Authors: Görgün Akpek, Shing M. Lee, David R. Gagnon, Timothy P. Cooley, Daniel G. Wright
Journal: American Journal of Hematology (2001)

Abstract Bone marrow (BM) aspiration and biopsy are used commonly in clinical practice to diagnose invasive tissue infections caused by Mycobacterium avium intracellulare (MAC), Mycobacterium tuberculosis (TB), and Histoplasma capsulatum (HC) in patients with human immunodeficiency virus‐1 (HIV) infection. However, the value of these invasive procedures relative to other diagnostic approaches has not been clearly defined. To determine the value of BM culture and BM histology in the diagnosis of opportunistic MAC/TB and HC infections in immunosuppressed patients with HIV, we retrospectively reviewed the records of 56 adult patients with HIV who underwent a single BM aspiration, biopsy, and culture because of unexplained fever and/or other clinical features suggestive of MAC/TB or HC infection. Thirty‐two patients (57%) were ultimately diagnosed with MAC/TB or HC infection by positive cultures of BM, blood, sputum, or bronchoalveolar lavage fluid or by the histologic detection of organisms in biopsies of BM or other tissues. The diagnostic sensitivity of BM cultures was equal to that of blood cultures (20/32, or 63%). Granuloma and/or histologically apparent organisms were seen in BM biopsy specimens in 11 of 32 individuals (34%) ultimately diagnosed with MAC/TB or HC infections. Among these 11 cases, both granuloma and acid‐fast staining organisms were found in the BM biopsy specimens of 2 individuals for whom both BM and blood cultures were negative. Certain clinical symptoms and signs at the time of BM examination were found by logistic regression analysis to be significantly associated with a subsequent diagnosis of MAC/TB or HC infections; these included high fever, long duration of febrile days prior to BM examination, and elevated direct bilirubin. In conclusion, while the diagnostic sensitivity of BM cultures was found to be no greater than that of blood cultures in detecting MAC/TB or HC infections in immunosuppressed HIV + patients, histopathologic examination of BM specimens resulted in the relatively rapid identification of nearly one third of infected patients who underwent BM examination, and also identified infections in some patients who were culture negative. These findings support the continued use of BM aspiration, biopsy, and culture for the diagnosis of opportunistic MAC/TB or HC infections in immunosuppressed HIV + patients, particularly when selected clinical features are present. Am. J. Hematol. 67:100–106, 2001. © 2001 Wiley‐Liss, Inc.
Debate over NHS-wide network is centred on wrong issue
Authors: M F Smith
Journal: BMJ (1996)

the ways in which health authonties and general practice purchasers now make their decisions, so that recommendations that are made can be trans- lated into practice.A National Council for Health Care Prionties should draw on this information and experience from other countries in developing methods for determining priorities and monitorng how they are set while protecting training, research, and development.
Roche should be sued to release data on oseltamivir, says Cochrane leader
Authors: Z. Kmietowicz
Journal: BMJ (2012)

A leading Cochrane researcher has suggested that European governments should sue the drug firm Roche and that doctors and others boycott the company’s products until it published all its data on oseltamivir (Tamiflu).

Peter Gotzsche, head of the Nordic Cochrane Centre in Copenhagen, was responding to an open letter to Roche from the BMJ ’s editor in chief, Fiona Godlee.

His plea came the same week as Godlee and other campaigners met with the health minster Lord Howe to discuss missing data, European Union clinical trial regulation, and the role of regulators.

Afterwards Sarah Wollaston, the Conservative MP who last month asked in parliament for a meeting on the issue,1 said she hoped to have a full day’s event to discuss further what could be done.

She told the BMJ , “Few would buy a car without comparing fuel economy and safety, yet the NHS pays for drugs without insisting on seeing all the data. We have many levers to insist on sharing this …
Behavioral Consequences of AIDS Antibody Testing Among Gay Men
Authors: Thomas J. Coates
Journal: JAMA (1987)

To the Editor.—  We followed up 502 gay and bisexual men from 1984 (before human immunodeficiency virus antibody testing was available) until 1986 (after testing was available) to determine the consequences of human immunodeficiency virus antibody testing on high-risk sexual behavior. The sample was recruited in 1983 and 1984 from bars, bathhouses, and newspaper advertisements calling for men who were celibate or in committed relationships.1Ninety-one percent of the sample were white, 67% were college graduates, 82% were employed full-time, and 98% were exclusively or almost exclusively homosexual. The cohort was surveyed each November and asked to report the frequency of specific sexual acts during the previous month. We also asked whether they had been tested for antibodies to the acquired immunodeficiency syndrome virus in the year prior to the survey and for the test result if known.  As of November 1986, 40.8% had been tested. Of those tested,
Durable remission of pure red cell aplasia after treatment with high‐dose intravenous gammaglobulin and prednisone
Authors: Samuel W. Needleman
Journal: American Journal of Hematology (1989)

Abstract Pure red cell aplasia (PRCA) is a rare disorder of erythrocyte production believed to have an autoimmune basis in most cases. Responses to a variety of immunosuppressive regimens are regularly observed, but toxicity is considerable. Brief responses to high‐dose intravenous immunoglobulin (IVIg) have been previously reported. This case demonstrates a durable clinical remission of PRCA treated with IVIg and glucocorticoids.
Bloody diarrhea caused by enterohemorrhagic<i>Escherichia coli</i>(EHEC)
Authors: H. Neumann, M. Hunstiger, C. Langner, M. Neurath, M. Vieth
Journal: Endoscopy (2011)

Infection with enterohemorrhagic Escherichia coli (EHEC) has been spreading in Germany since the second week of May and causing considerable concern among the population. At the time of writing, nine deaths have been reported due to the subsequent development of hemolytic uraemic syndrome (HUS), but the source of the outbreak is still unknown. As of May 31, 2011, the Robert Koch Institut, Berlin, Germany, has confirmed a total of 470 cases of HUS and stated that this epidemic has not yet reached its climax [1].
Beta-adrenoceptor stimulation attenuates the hypertrophic effect of alpha-adrenoceptor stimulation in adult rat ventricular cardiomyocytes
Authors: Matthias Schäfer, Klaus Pönicke, Ingrid Heinroth-Hoffmann, Otto-Erich Brodde, Hans Michael Piper, Klaus-Dieter Schlüter
Journal: Journal of the American College of Cardiology (2001)
ABC of eyes: Injury to the eye: Authors' reply
Authors: Peng Tee Khaw, Peter Shah, Andrew R Elkington
Journal: BMJ (2004)

Random drug testing in schools fails screening criteriaEditor-Last month the prime minister, Tony Blair, lent his weight to random drug testing in schools in an interview for a downmarket newspaper. 1He proposed a national programme be implemented soon, adhering to unspecified central directives.The Department of Health has 19 criteria for introducing new screening programmes. 2 At least 18 of these 19 criteria are not met for widespread, wide spectrum drug urine analysis in schools.The remaining criterion is that the condition is an important health problem.Drug use in young people is indeed associated with many health risks, 3 but a single, positive urine test, for any illicit drug, is probably not meaningful in a clinical sense.Each schoolchild's context of use (family history, social and emotional development) is crucial to interpreting any supposed "drug career."Use by a homeless pregnant teenage runaway from local authority care with a history of deliberate self harm and high risk sex work to pay for her drugs may be very different from a single experimental use at home with adults during a family party.Three failed criteria are especially pertinent to screening for school age drug use:(1) There should be an agreed policy on the further diagnostic investigation of people with a positive test result and on the choices available to them.(2) There should be an effective treatment or intervention for patients identified through early detection.(3) Clinical management of the condition and patient outcomes should be optimised by all healthcare providers before participation in a screening programme.In three years of experience of school health provision for alcohol and drug problems and their related referral networks I do not know of one school that could satisfy these criteria, especially the underpinning policy of promoting informed choice for children and families. 2
PD5-1-5: Radiation-induced elevation in plasma TGF-beta1 during radiation therapy may be predictive of radiation-induced lung toxicity in patients with non-small cell lung cancer: A combined analysis from Beijing and Michigan
Authors: Lujun Zhao, Luhua Wang, Wei Ji, Xiaozhen Wang, Xiangzhi Zhu, James Hayman, Gregory Kalemkerian, Weizhi Yang, Theodore Lawrence, Feng-Ming Kong
Journal: Journal of Thoracic Oncology (2007)
Early Papillary Stenosis Following Successful Endoscopic Sphincterotomy for Residual Common Bile Duct Stone
Authors: J.P. Richieri, G. Pelissier
Journal: Endoscopy (1984)

We report a case of early papillary stenosis following successful endoscopic sphincterotomy for residual common bile duct stone which needed surgical revision. In this rare and unexpected complication the importance of early diagnosis is stressed.
Oral administration of L-arginine and captopril in rats prevents chronic renal failure by nitric oxide production
Authors: Ishmail Ashab, Gary Peer, Miriam Blum, Yoram Wollman, Tamara Chernihovsky, Avi Hassner, Doron Schwartz, Shaltiel Cabili, Donald Silverberg, Adrian Iaina
Journal: Kidney International (1995)
Report on Cheese Poisoning Cases at Mansfield, Ohio.
Authors: R. Harvey Reed
Journal: JAMA (1893)

manded.An ordinance is not, in the constitutional sense, a public law.It is a mere local rule or by¬ law-a police or domestic regulation-devoid in many respects of the characteristics of the public or general laws.In this case a city ordinance was at¬ tacked as being unconstitutional, illegal, and viola- tive of the lawrs of the State ; the specific objection made being that the State having adopted a stand¬ ard of adulteration, it was the duty of the munici¬ pality to have made its standard identical with that of the State, and that, the two standards not being identical that of the city, by reason of that fact, was illegal.But, as already explained, the offense charged under the city ordinance would be a separate and distinct offense from that which would have been