A CLINICAL APPRAISAL OF NEOMYCIN
Authors: B A WAISBREN, W W SPINK
Journal: Annals of Internal Medicine (1950)

Article1 November 1950A CLINICAL APPRAISAL OF NEOMYCINBURTON A. WAISBREN, M.D., WESLEY W. SPINK, M.D., F.A.C.P.BURTON A. WAISBREN, M.D., WESLEY W. SPINK, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-5-1099 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNeomycin, an antibiotic derived from a strain of streptomycetes that is closely related to Streptomycetes fradiae, was discovered by Waksman and Lechevalier in 1949.1 It was a product of their search for an antibiotic that would be effective against streptomycin-resistant bacteria, particularly tubercle bacilli. Little has been reported as to the chemical nature of neomycin other than that it is a basic compound, heat stable, and is resistant to the action of acid (pH 2) at the temperature of boiling water.1Studies on the spectra of bacteria affected by neomycin have revealed the drug to be bactericidal in vitro against...Bibliography1. WaksmanLechevalier SHHA: Neomycin, a new antibiotic active against streptomycin resistant bacteria, including tuberculosis organisms, Science 109: 305, 1949. CrossrefMedlineGoogle Scholar2. WaisbrenSpink BAWW: Comparative activity of Q-19, neomycin, aureomycin, polymyxin B and chloromycetin against gram negative bacilli, Proc. Soc. Exper. Biol. and Med. 74: 35-40 (May) 1950. CrossrefMedlineGoogle Scholar3. WaksmanHutchinsonKatz SADE: Neomycin activity upon Mycobacterium tuberculosis and other mycobacteria, Am. Rev. Tuberc. 60: 78, 1949. MedlineGoogle Scholar4. WarthChandlerBliss PTCAEA: The antibacterial action of neomycin and furadroxyl in vitro and in vivo, Bull. Johns Hopkins Hosp. 86: 169, 1950. Google Scholar5. WaksmanLechevalierHarris SAHHDF: Neomycin—production and antibiotic properties, J. Clin. Investigation 28: 934, 1949. CrossrefMedlineGoogle Scholar6. ColingsworthJohnson DRLE: Personal communication, 1950. Google Scholar7. Karlson AG: Personal communication, 1950. Google Scholar8. Rake G: The streptomycins and neomycin in murine tuberculosis, Ann. New York Acad. Sc. 52: 765, 1949. CrossrefMedlineGoogle Scholar9. HobbyLenertDougherty GLTFN: The evaluation of neomycin and other antimicrobial agents of bacterial and fungal origin and substances from higher plants, Ann. New York Acad. Sc. 52: 775, 1949. CrossrefMedlineGoogle Scholar10. HobsonMcDermott LBW: Criteria for clinical evaluation of anti-tuberculous agents, Ann. New York Acad. Sc. 52: 782, 1949. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota*Received for publication June 30, 1950.From the Department of Medicine of the University of Minnesota Hospitals and Medical School, Minneapolis. 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LiteraturverzeichnisDeafness after Topical Neomycin Wound IrrigationStreptomycin, Kanamycin, Neomycin and ParomomycinKlinik und Pathologie der Aerobacter aerogenes-InfektionLong-Term Reduction of Serum Cholesterol Levels of Patients with Atherosclerosis by Small Doses of NeomycinTHE BROAD-SPECTRUM ANTIBIOTICSAction of Streptomycin, Dihydrostreptomycin, Neomycin and Kanamycin on the Ampullar Receptors of the FrogReferencesHÆMODIALYSIS IN ACUTE PORPHYRIAOtotoxicity of Neomycin and other AntibioticsOn the nephrotoxicity of amphotericin B in manReferencesHypothermia as a Therapeutic Adjunct in Management of Bacteremic Shock after Urological SurgeryNEOMYCIN-RESISTANT STAPHYLOCOCCISPINAL INJURY INVOLVING THE JEJUNUMOTOTOXICITY OF NEOMYCIN AEROSOLAbsorption of Orally Administered Neomycin and KanamycinSystemic Absorption of Orally Administered Neomycin in Liver DiseaseAbsorption of Nonabsorbable AntibioticsBlood Ammonia Levels in Hepatic CirrhosisDie antibiotische Lokaltherapie der S�uglingsdyspepsien mit NebacetinAntibiotikaDie akuten NephrosenThe Ototoxicity of Neomycin: Experimental InvestigationsChemistry of antibiotics of clinical importanceChemotherapeutic and antibiotic drugs in the management of infections of the urinary tractThe chemotherapy of bacterial infections refractory to the common antibioticsTOPICAL HYDROCORTISONE AND NEOMYCIN IN THE EXTERNAL EARUse of Antibiotics in Surgery of the AgedXCVI The Ototoxicity of Dihydrostreptomycin and Neomycin in the CatThe Chemical Approach to the Control of TuberculosisChloramphenicol in the treatment of meningococcal meningitis 1 November 1950Volume 33, Issue 5Page: 1099-1119KeywordsAntibioticsBacteriaDrugsHospital medicineNeomycinsTemperature ePublished: 1 December 2008 Issue Published: 1 November 1950 PDF downloadLoading ...