tbuckley/cabot-search huggingface dataset:
Insurance Fees and Lodge Practice
Authors: M. V. Ball
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influence of Time Delay on the Estimated Lung Shunt Fraction on 99mTc-Labeled MAA Scintigraphy for 90Y Microsphere Treatment Planning
Authors: Ruth De Gersem, Geert Maleux, Hubert Vanbilloen, Kristof Baete, Chris Verslype, Karin Haustermans, Alfons Verbruggen, Eric Van Cutsem, Christophe Michel Deroose
Journal: Clinical Nuclear Medicine (2013)

90Y-microspheres therapy is used to treat selected patients with primary or metastatic liver tumors in a safe and effective way. As a preparation for 90Y-microspheres treatment, a 99mTc-macroaggregated albumin (99mTc-MAA) simulation procedure is essential to evaluate particle shunting to the lung or gastrointestinal tract. We investigated the effect of interval between injection of 99mTc-MAA and time of scanning on the lung shunt fraction (LSF). In 4 patients with secondary hepatic malignancies who underwent repeated whole-body scintigraphy up to 5 hours after injection of 99mTc-MAA, a marked change in LSF was observed. It appears that tracer degradation leads to an important overestimation of LSF at later time points. An overestimation of LSF can lead to dose reduction or canceling of the planned 90Y-microspheres treatment. It is concluded that the interval between injection and scanning should be kept as short as possible.
Professional Blood Donors
Authors: Coye C. Mason
Journal: JAMA (1963)

To the Editor:  —I note with considerable interest Dr. Robert Carroll's remarks on the reliability of the  blood  (Regional Notes, JAMA  83 : Adv p 32, 1963). I gather from his article that he is opposed to the use of   in a community blood-bank program.  The term professional donor is a misnomer in that the donation of a pint of blood is a voluntary act requiring only good health. Certainly no special skill or training is involved. I would like to suggest that the term selected donors would more accurately describe the individuals who are compensated directly for their time and inconvenience in making a donation of blood.  In his discussion, Dr. Carroll relates that, for pecuniary interests, the   is tempted to falsify his answers to the questions that are posed during the initial interview. I believe that it is important to point out that
Benzodiazepine prescribing to elderly people after hospital discharge can lead to chronic use
Authors: Barbara Kermode-Scott
Journal: BMJ (2007)

New prescriptions of benzodiazepines after hospitalisation, which are often given to elderly people, may lead to chronic use, with its associated risks, says a new Canadian study.

“Our data demonstrate that about half of patients dispensed benzodiazepines within the first week after hospital discharge fill another prescription in the next six months,” said the study's principal investigator, Chaim Bell, an adjunct scientist with the Institute for Clinical Evaluative Sciences in Toronto.

In the retrospective cohort study, the researchers used linked, population based administrative data to track the use of benzodiazepines …
Clinical quality should be put at the centre of care
Authors: W. G Pickering
Journal: BMJ (2002)

EDITOR—The multiplicity of recommendations of the non-medical report into the performance failures of the heart surgeons at Bristol Royal Infirmary1 prompts Coulter to repeat the slogan “put patients at the centre.”2 The primary issue—that of poor clinical practice going unchecked—has again been obfuscated. The failure of clinical self regulation caused the serial disasters at Bristol; smothering this uncomfortable truth risks its remedy.

Coulter says that openness and empathy should be shown to patients after …
Optimal Oral Anticoagulant Therapy in Patients with Mechanical Heart Valves
Authors: S.C. Cannegieter, F.R. Rosendaal, A.R. Wintzen, F.J.M. van der Meer, J.P. Vandenbroucke, E. Briet
Journal: New England Journal of Medicine (1995)

The optimal intensity of oral anticoagulant therapy for patients with mechanical heart valves (i.e., the level at which thromboembolic complications are effectively prevented without excessive bleeding) is not known. We attempted to determine the optimal intensity by calculating the incidence of both complications at different levels of anticoagulation.
Platelet count is not a predictor of the presence or development of gastroesophageal varices in cirrhosis
Authors: Amir A. Qamar, Norman D. Grace, Roberto J. Groszmann, Guadalupe Garcia-Tsao, Jaime Bosch, Andrew K. Burroughs, Rie Maurer, Ramon Planas, Angels Escorsell, Juan Carlos Garcia-Pagan, David Patch, Daniel S. Matloff, Robert Makuch
Journal: Hepatology (2007)

Current guidelines recommend esophagogastroduodenoscopy (EGD) in patients with cirrhosis to screen for gastroesophageal varices (GEV). Thrombocytopenia has been proposed as a noninvasive test to predict the presence of GEV. There is no agreement regarding a specific platelet count (PLT) that can reliably predict GEV. The present longitudinal study aims to (1) further investigate the relationship between varices and PLT at the time of endoscopy, (2) investigate whether changes in PLT from the baseline over time can predict the development of GEV, and (3) investigate whether changes in PLT correlate with the hepatic venous pressure gradient (HVPG). A secondary analysis was conducted for 213 subjects with compensated cirrhosis with portal hypertension but without GEV enrolled in a randomized, placebo-controlled, double-blind trial of a nonselective beta-blocker used to prevent GEV. PLTs were obtained every 3 months, and HVPG measurements and EGD were done annually. The PLTs were compared between subjects who did and did not develop GEV. In a median follow-up of 54.9 months, 84 patients developed GEV. PLT was greater than 150,000 in 15% of patients at the development of GEV. A receiver operating curve did not show any PLT with high sensitivity or specificity for the presence of GEV. Subjects with clinically insignificant portal hypertension (HVPG &lt; 10 mm Hg) whose PLT remained greater than 100,000 had a 2-fold reduction in the occurrence of GEV ( P = 0.0374). A significant correlation was found between HVPG and PLT at the baseline, year 1, and year 5 ( P &lt; 0.0001). Conclusion: Cross-sectional or longitudinal evaluations of PLTs are inadequate noninvasive markers for GEV. Patients with mild portal hypertension whose PLT remains greater than 100,000 have significantly less risk of GEV. Although HVPG correlates somewhat with PLT, changes in PLT cannot be used as a surrogate for HVPG changes. (Hepatology 2008;47:153–159.)
A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia
Authors: William M. Gordon, Michael D. Zeller, Rachel H. Klein, William R. Swindell, Hsiang Ho, Francisco Espetia, Johann E. Gudjonsson, Pierre F. Baldi, Bogi Andersen
Journal: Journal of Clinical Investigation (2014)

Dermal infiltration of T cells is an important step in the onset and progression of immune-mediated skin diseases such as psoriasis; however, it is not known whether epidermal factors play a primary role in the development of these diseases. Here, we determined that the prodifferentiation transcription factor grainyhead-like 3 (GRHL3), which is essential during epidermal development, is dispensable for adult skin homeostasis, but required for barrier repair after adult epidermal injury. Consistent with activation of a GRHL3-regulated repair pathway in psoriasis, we found that GRHL3 is upregulated in lesional skin and binds known epidermal differentiation gene targets. Using an imiquimod-induced model of immune-mediated epidermal hyperplasia, we found that mice lacking GRHL3 have an exacerbated epidermal damage response, greater sensitivity to disease induction, delayed resolution of epidermal lesions, and resistance to anti–IL-22 therapy compared with WT animals. ChIP-Seq and gene expression profiling of murine skin revealed that while GRHL3 regulates differentiation pathways both during development and during repair from immune-mediated damage, it targets distinct sets of genes in the 2 processes. In particular, GRHL3 suppressed a number of alarmin and other proinflammatory genes after immune injury. This study identifies a GRHL3-regulated epidermal barrier repair pathway that suppresses disease initiation and helps resolve existing lesions in immune-mediated epidermal hyperplasia.
Is Routine Screening for Melanoma a Benign Practice?
Authors: Richard L. Edman
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chlamydia trachomatis and ascites: Going with the flow?
Authors: Marc J. Shabot
Journal: Hepatology (1989)

Chlamydia trachomatis as an etiological agent in the Fitz-Hugh-Curtis syndrome has recently been reported; however, the condition has not been typically associated with ascites. We report a case of Chlamydia trachomatis perihepatitis in a young woman who had exudative ascites as a predominant clinical feature of her disease. Laparoscopy revealed characteristic “violin string” adhesions which were also identified on abdominal computerized scan.
Acute myeloid leukemia with MLL rearrangements: clinicobiological features, prognostic impact and value of flow cytometry in the detection of residual leukemic cells
Authors: L Muñoz, J F Nomdedéu, N Villamor, R Guardia, D Colomer, J M Ribera, J P Torres, J J Berlanga, C Fernández, A Llorente, M P Queipo de Llano, J M Sánchez, S Brunet, J Sierra
Journal: Leukemia (2003)
Rectus Abdominis Nerve Entrapment Syndrome
Authors: Alfred S. Tung
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Recognition of pain secondary to abdominal wall pathologic conditions may prevent unnecessary laparotomies. <h3>Report of a Case.—</h3> In February 1978, a 33-year-old woman came to our Pain Control Center with a one-year history of lower left abdominal pain during the midpoint of her menstrual cycle. Over the course of a year, this patient consulted frequently with her gynecologist, who could not relieve her pain with conservative drug or hormonal therapy. After a normal laparotomy in October 1977, the patient was referred to us for evaluation before a planned hysterectomy. While attempting to differentiate between pain of visceral or somatic origin, we noted the pain and tenderness to palpation over the left abdomen was intensified as the abdominal muscles were contracted via leg lift in the supine position. This sign in a patient with chronic pain is strongly suggestive of a nerve entrapment syndrome involving the rectus abdominis
379 COMPARISSON OF HEPATITIS B CCCDNA BETWEEN PARAFFIN-EMBEDDED AND CRYO-PRESERVED LIVER BIOPSIES OF CHRONIC HEPATITIS B PATIENTS
Authors: B. Takkenberg, H. Zaaijer, S. Menting, C. Weegink, V. Terpstra, M. Dijkgraaf, M. Cornelissen, P. Jansen, H. Reesink, M. Beld
Journal: Journal of Hepatology (2009)
Etiology, Pathogenesis, and Early Diagnosis of Ischemic Necrosis of the Hip
Authors: Harry J. Griffiths
Journal: JAMA (1981)

ISCHEMIC necrosis (avascular necrosis, osteonecrosis) may occur in almost any bone of the skeleton. The most common site for ischemic necrosis is the head of the femur, and it is here that early diagnosis has proved to be most difficult. The patient often complains of pain, sometimes during a period of several months before any specific radiological findings become visible. It is possible to make the diagnosis earlier if clinical suspicion is high and certain specific roentgenograms are obtained. Many centers are using radioisotopes in an attempt to demonstrate changes before those observed radiologically. Although the computed tomographic (CT) scanner is an excellent method for confirming advanced disease, so far it has not proved useful in the diagnosis of early ischemic necrosis. <h3>The Etiology of Ischemic Necrosis</h3> The causes of osteonecrosis may be subdivided into three categories: posttraumatic (the most common), nontraumatic (including embolic small-vessel disease and abnormal deposition of
Cure of insulin-dependent diabetes mellitus by removal of a glucagonoma.
Authors: S L Lightman, S R Bloom
Journal: BMJ (1974)

and the fact that in most of them liver disease was unsuspected or discovered fortuitously, unlike our patient, imply that it is a rare cause of symptomatic cirrhosis in adults.Nevertheless, aol-antitrypsin deficiency should be considered in adult cirrhotic patients with unusual pathological features and when there is no other obvious aetiology.Suspicion should also be raised when there is a history of hepatic disease in infancy or childhood, as seen in our patient and the case reported by Ishak (1972), even though it is apparently very rare for such children to survive into adult life.Homozygous or heterozygous deficiency of al-antitrypsin will be common among close relatives of such patients, as shown by our family study.Recognition of these subjects in affected families is probably important, since avoidance of contributory causes of obstructive airways disease, such as smoking, may prevent or halt the progress of the condition.This may also apply to alcohol with respect to the liver, but at present the prognosis of hepatic disease in adults is unknown and it is only by identification and follow up of these patients that further knowledge will be obtained.
Book: The History of the Royal College of Physicians and Surgeons of Glasgow: Physicians and Surgeons in Glasgow, 1599-1858 The History of the Royal College of Physicians and Surgeons of Glasgow: Physicians and Surgeons in Glasgow, 1858-1999
Authors: J. H. Baron
Journal: BMJ (2000)

Johanna Geyer-Kordesch, Fiona Macdonald Hambledon Press, £30, pp 478 ISBN 1 85285 186 4 Andrew Hull, Johanna Geyer-Kordesch Hambledon Press, £30, pp 288 ISBN 1 85285 187 2 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> ![Graphic][4]</img> Most of the major royal colleges have commissioned solid scholarly histories. Here is the latest, representing five years' work by three historians of medicine funded by the Wellcome Trust. But the titles are misleading because, rather than merely being an account of the Glasgow Faculty and of the physicians and surgeons of Glasgow, the pair of books are admirably more comprehensive and interesting. They cover the whole history of medicine, in the broadest sense, of Glasgow and western Scotland from the 16th century, and even the medical novels of Smollett and John Moore. When it was founded in 1599, the Glasgow Faculty included not only physicians and surgeons … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
The Practical Management of Depression
Authors: Nathan S. Kline
Journal: JAMA (1964)

MORE HUMAN SUFFERING has resulted from depression than from any other single disease. Despite their relatively recent introduction into medical practice, antidepressants are used in the treatment of over 4 million patients a year in the United States. Unfortunately our inability to detect certain types of depression or to get all obvious cases to come for therapy contribute to 20,000<i>known</i>suicides a year in the US, and at least twice that number who go undetected. Two million persons in this country are estimated to have made at least one suicidal attempt.<sup>2</sup>Multiple millions more of mildly depressed patients never seek help because they actually fail to realize that they are ill. Lest it be felt this is a peculiarly American phenomenon, the evidence is clear that depression is world-wide in distribution and probably in incidence. Earlier theories that it was nonexistent or extremely low in certain parts of
LUMBAR NEPHROPEXY WITHOUT SUTURING.
Authors: N. SENN
Journal: JAMA (1897)

Nephrorrhaphy for the fixation of movable kidney has had an extensive trial at the hands of the surgical profession ever since the operation was suggested and first practiced by E. Hahn of Berlin. There can be but little doubt that the operation has been performed many times unnecessarily in cases in which the symptoms were not produced by the displaced organ, and consequently failed to procure the expected relief. Nephropexy is a legitimate and established surgical procedure in all cases in which it can be established that the kidney is not only displaced, but is at the same time the direct cause of the manifold symptoms which such a condition may and often will produce. The many modifications which the operation has undergone is perhaps the best proof that the results heretofore obtained by the different methods devised have not proved satisfactory. In nearly all of the operations the kidney
If the Tap Water Smells Foul, Think MTBE
Authors: Carol R. Angle
Journal: JAMA (1991)

<h3>To the Editor.</h3> —Methyl tertiary butyl ether (MTBE, CAS No. 1634-04-4) is a water-soluble gasoline additive of such increasing use that it is the fastest growing chemical product in US industry (<i>Chem Eng News</i>. June 10, 1991:13). A recent familial exposure suggests that the foul odor of MTBE may fortuitously serve as a sentinel for gasoline contamination. A family of five moved to a farmstead on a quarter-mile tract between a gasoline pipeline terminal and a river. Six months earlier, the groundwater (6 to 8 feet in depth) at the terminal had been visibly contaminated with gasoline. The family sank a new well to 60 feet. Thirty months later, the household water became rapidly and progressively malodorous. It did not smell like gasoline. The family drank bottled water, but the tap water used for baths, laundry, and dishwashing evoked headache, dizziness, nausea, and dyspnea in all five family members. Well-water
Leptin Induces Hypertrophy via Endothelin-1–Reactive Oxygen Species Pathway in Cultured Neonatal Rat Cardiomyocytes
Authors: Fang-Ping Xu, Min-Sheng Chen, Yan-Zhen Wang, Quan Yi, Shu-Bing Lin, Alex F. Chen, Jian-Dong Luo
Journal: Circulation (2004)

Obesity is a major risk factor for the development of cardiovascular disease. Emerging evidence indicates that leptin, a protein encoded by the obesity gene, is linked with cardiac hypertrophy in obese humans and directly induces cardiomyocyte hypertrophy in vitro. However, the mechanisms by which leptin induces cardiomyocyte hypertrophy are poorly understood.This study investigated how leptin contributes to cardiomyocyte hypertrophy. Cultured neonatal rat cardiomyocytes were used to evaluate the effects of leptin on hypertrophy. Both endothelin-1 (ET-1) and reactive oxygen species (ROS) levels were elevated in a concentration-dependent manner in cardiomyocytes treated with leptin for 4 hours compared with those cells without leptin treatment. ET-1 stimulated ROS production in a concentration-dependent manner in cardiomyocytes. The augmentation of ROS levels in cardiomyocytes treated with both leptin and ET-1 was reversed by a selective ET(A) receptor antagonist, ABT-627, and catalase, a hydrogen peroxide-decomposing enzyme. After treatment for 72 hours, leptin or ET-1 concentration-dependently increased total RNA levels, cell surface areas, and protein synthesis in cardiomyocytes, all of which were significantly inhibited by ABT-627 or catalase treatment.These findings indicate that leptin elevates ET-1 and ROS levels, resulting in hypertrophy of cultured neonatal rat cardiac myocytes. The ET-1-ET(A)-ROS pathway may be involved in cardiomyocyte hypertrophy induced by leptin. ET(A) receptor antagonists and antioxidant therapy may provide an effective means of ameliorating cardiac dysfunction in obese humans.
AN INTERESTING CASE OF INCONTINENCE OF FECES IN AN UNDERSIZED BOY OF SIX YEARS.
Authors: MAURICE OSTHEIMER
Journal: JAMA (1907)

When, two years ago, three boys with incontinence of both urine and feces were brought to the Children's Dispensary, University Hospital, inside of three months, I reviewed the literature<sup>1</sup>on incontinence of feces in childhood and could find altogether only twelve cases in children over three years of age. Another recent review of the literature from 1904 to the present time failed to reveal any more cases of this condition. <h3>Patient.</h3> —In February, 1907, a very small, rather stout, ruddy-cheeked boy of six years was brought to me with this history: <h3>History.</h3> —His parents, who are well, are both short and stout. The father is a motorman. John is the fourth child, born after a protracted labor, without instruments, however. He was a large, well-developed baby at birth and had never been seriously ill. He was breast-fed until nine months of age, was then weaned, and given table food soon
Teaching in Medical Colleges.
Authors: J. M. G. Carter
Journal: JAMA (1894)

Waukegan, Ill., Dec. 9, 1894. <h3>To the Editor:</h3> —Allow me to make some suggestions relative to systematic instruction in medical colleges. This matter is forced upon our attention by the criticisms of medical teaching by students from other schools. The time has come when a systematic grouping of subjects to be taught should be adopted by all schools that desire to be known as eminent centers of learning. This system has been adopted by some of the literary and scientific institutions of our country; but it is far from being universal. In medical colleges the plan has scarcely received a serious thought. Only a few schools where medical men are trained have arranged for such united, such systematic work. The president or dean of a college of medicine should know what is taught in every department, in every chair. This would entail a vast amount of work upon one man,