tbuckley/cabot-search huggingface dataset:
Percutaneous Transluminal Renal Angioplasty in Renovascular Hypertension Due to Atheroma or Fibromuscular Dysplasia
Authors: Thomas A. Sos, Thomas G. Pickering, Kenneth Sniderman, Souheil Saddekni, David B. Case, Michael F. Silane, E. Darracott Vaughan, John H. Laragh
Journal: New England Journal of Medicine (1983)

We attempted percutaneous transluminal renal angioplasty in 89 patients with hypertension and renal-artery stenosis (including 51 with atheromatous and 31 with fibromuscular stenoses) who were then followed for an average of 16 months (range, 4 to 40). Angioplasty was technically successful in 87 per cent of the fibromuscular stenoses and in 57 per cent of the unilateral atheromatous stenoses but in only 10 per cent of the bilateral atheromatous stenoses. After successful angioplasty, blood pressure was reduced to normal or improved in 93 per cent of the patients with fibromuscular dysplasia and in 84 per cent of the patients with atheromatous disease. Angiographic follow-up at an average of 21.8 months in 15 patients showed persistent relief of the stenoses and a 12 per cent average increase in kidney size. Renal angioplasty is effective for long-term control of hypertension in patients with renal-artery stenosis due to fibromuscular dysplasia or unilateral non-ostial atheroma.
Soft Tissue Rheumatic Pain (2nd Edition)
Authors: Lorna Fisher
Journal: British Journal of Sports Medicine (1987)

This book is well written and presented with clear headings, tables and illustrations.It is also very well referenced.The authors have tried to address the problem of non-articular and non-inflammatory conditions when these need to be considered in the differential diagnosis.A very relaxed interpretation of what constituted 'soft tissue' has allowed the inclusion of conditions such as osteochondritis, osteomalacia and osteoporosis.Conversely, virtually no mention is made of metabolic and endocrine causes of soft tissue rheumatic pain.Throughout the book the emphasis is on establishing a diagnosis from the history and examination without resorting to unnecessary and expensive investigations.Features that warrant further investigation are clearly stated.Similarly, stress is placed on patient management including preventative measures, education, intra-lesional injection techniques and detailed exercise regimes.The commoner soft tissue rheumatic problems are dealt with according to anatomical site.The chapters on the knee and ankle and foot are particularly useful, but I found the chapter on the shoulder repetitive and confusing.The statement 'Frozen shoulder begins insidiously and is not often a cause for severe pain' must be questioned.The last few chapters cover a miscellany of topics, including fibrositis syndrome, psychogenic rheumatism and the management of chronic persistent pain syndrome.In summary, this book deals comprehensively with the commoner non-inflammatory soft tissue rheumatic diseases.It will also be of particular interest to the Rheumatologist, Orthopaedic Surgeon and some General Practitioners.Although not directly specifically at the Sports Medicine market, the excellent advice on the management of overuse syndromes will make this a very useful book for anyone dealing with sports injuries.
The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells
Authors: Sumaiya Sharmeen, Marko Skrtic, Mahadeo A. Sukhai, Rose Hurren, Marcela Gronda, Xiaoming Wang, Sonali B. Fonseca, Hong Sun, Tabitha E. Wood, Richard Ward, Mark D. Minden, Robert A. Batey, Alessandro Datti, Jeff Wrana, Shana O. Kelley, Aaron D. Schimmer
Journal: Blood (2010)
Somewhere Under the Iceberg
Authors: Philip L. White
Journal: JAMA (1976)

RECENT criticism of the nutritional care of hospitalized patients may have irked physicians who feel that the medical profession receives enough criticism as it is. We know of a number of hospitals that have responded by reevaluating their own patient-monitoring practices to ensure that the episodes reported will not be repeated. Hopefully, the frank discussions of malnutrition in American hospitals will result in positive remedial action rather than negative reaction. The AMA Council on Foods and Nutrition strongly recommends the formation of hospital nutrition committees and petitioned the Joint Commission on Accreditation of Hospitals to support the recommendation. A splendid working model of a nutrition support service has been described by George L. Blackburn, MD.<sup>1</sup> The dramatic examples of iatrogenic malnutrition made challenging subject histories. In the case of the articles by C. E. Butterworth, MD, they also made embarrassing headlines.<sup>2,3</sup>We suspect that the examples cited were
Primary Cervical Dystocia Treated with Caudal Analgesia
Authors: H. C. J. Ball, J. S. W. Chambers
Journal: BMJ (1956)

SYSTEMIC LUPUS ERYTHEMATOSUStBoH 1275 fever, but this may have been due to bronchopulmonary in- fection.She is not known to have been given sulphonamides between March and December, 1952.There were no symp- toms or signs before the episodes of sulphonamide hyper- sensitivity that could have been interpreted as a part of the clinical picture of S.L.E.It has been pointed out that various drugs, including sulphonamides, may induce acute exacerbations of estab- lished S.L.E., and it is reasonable to suppose that such an episode might represent the first overt manifestation of the disease.In this case the administration of sulphonamide appears to have been the trigger which set the disease pro- cess in motion, in a patient of the appropriate constitutional type.It is considered that this case provides additional circumstantial evidence for the concept of S.L.E. as a hyper- sensitivity disease.It is not, of course, suggested that sulphonamides are the only agents which can act in this way, nor that a sulphonamide hypersensitivity reaction necessarily constitutes a part of S.L.E. Summary and ConclusionsA case of systemic lupus erythematosus is described in which the onset was preceded by severe sulphonamide hypersensitivity.The evidence that S.L.E. may be an allergic disease is briefly reviewed, and the role of sulphonamides dis- cussed.This case appears to provide additional circumstantial evidence for the belief that sulphonamides may some- times be an important aetiological factor in S.L.E.This patient also developed the nephrotic syndrome and hypertensive encephalopathy; the latter was success- fully controlled by hexamethonium.
Making the new deal for junior doctors happen
Authors: J K Moore, W D Neithercut, A S Mellors, D Manning, C A Makin, H Jones, R J Alman, M Ali-Bachari
Journal: BMJ (1994)

How can the new deal for juniors be implemented in today's overstretched health service?How do you get clinicians and management to work together?On the Wirral falling house officer morale and recruitment stimulated a new approach, action learning, which proved to be highly successful.Action learning is not a new approach in management terms, but it is rarely used in the health service.Guided by an experienced facilitator, a group of people learn management skills by exploring and resolving practical problems relevant to them.A group of general practitioners and consultants used action learning to teach themselves more about management and at the same time to make changes which addressed many of the junior doctors' diffi- culties and solved the hospital recruiting problem.
Canada creates new national blood service
Authors: D. Spurgeon
Journal: BMJ (1997)

Canada is to get a new national blood service as a result of the work of a commission of inquiry into a scandal that left thousands of Canadians infected with HIV and hepatitis C from transfusions.

The four year inquiry cost around $C57m (£25m; $40m) and embroiled governments, pharmaceutical companies, the Canadian Red Cross Society, and hundreds of individuals …
Address in Public Medicine
Authors: T. J. Dyke
Journal: BMJ (1885)

tAt 1, 1â re necessary for the cuisine of the sick-room and nir'seiy;1 J'think I could do so very briefly.In addition to the resourceq of the dosestic Iitchen and larder, the sick-room kitchen should cont'a"nS' s'pply ;of the following flours: oat, maize.malt, and lentil fou-sin, rAnely pulverised condition, and freed from bran.It should b t po'tided with a solution of soda-bicarbonate of known strengtp.'TiL wvrild be of use to add to milk when necessary, and to assist in tpe ,pipra.tion of peptonised articles'of food.Next to these would, come' a re- liable pancreatic extract, and a preparation of pepsin 6i,rennet for`the production of whey.The associated apparatus should Wcliude a thermometer, wherewith the nurse could, when desirable, heat, up cold-made meat-infusions to a proper temperature, a'nd'`egut`lat the warmth required in the predigestion of food.A double-cased taiceiepan would form an indispensable item ; this makes an admirable hbt-water bath for the preparation of beef-tea and fortified griels.A 'pair. of scales, glass-measures, and a mincing-machine would coifplete the list.Finally, there should be, for the service of the nurse, 'a' erd or sheet containing plain directions for the preparation' of<tle various kinds of liquid food.4Given these sim,ple appliances, I see no difficulty, in''thse 'days of skilled nursing, in the medical attendant being able 'to prescribe almost any kind of liquid food for his patients in any eombination, and having it served up for the invalid in the most suitable possibleiianner.I have ascertained that there is no difficulty on the paYt of thi"w iller in producing meals from malt, oats, or lentils, freed from, bran 'and 'coarser particles, and in nearly as fine a state of preparation as wh,eaten flour.In this state, these meals are susceptible of 'much more rapid and perfect cooking than when roughly groundLi I have little sympathy with much that has been said of the advaitages of whole meal and decorticated flour.It has been alleged, that the too complete separation of the outer parts of the grain deprivs the flour of its mineral matter.If we lived on bread alone, theie would be some force in this objection ; but as that is not so, and that we find in milk, meat, fish, eggs, soups, and fresh vegetables, a 'suprabun- dant provision of mineral matter, and have, moreover, always, at our elbows a supply of salt, there can never be any lack of saliie materials in our food.The branny matter of the flour is both mdi estible and irritating to the primae vim; and although it may not injure,' or may even be useful, to the strong and healthv, it is quite an unfit element in food designed for the weak and tender membranes of the invalid and infant.Gentlemen, in bringing,my remarks to a close, I shouid like again to press for a more systematic and a more comprehensive' study of dietetics.The effects of diet are profound and far-reachinlo and ex- ~eedingly subtle.Some inkling of this is got from the ristory of gout.You all know how slowly and how insidiously the gouty
Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Hypocalcemia, and Hypomagnesemia
Authors: M. N. Potter
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 May 1990Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Hypocalcemia, and HypomagnesemiaM. N. Potter, MB, M. G. Mott, MB, A. Oakhill, MBM. N. Potter, MBSearch for more papers by this author, M. G. Mott, MBSearch for more papers by this author, A. Oakhill, MBSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-9-715_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is currently being studied as a possible therapy for severe aplastic anemia, although the myelopoietic response to such therapy is usually only transient (1) and is often disappointing in patients with very severe neutropenia (2). Adverse metabolic effects associated with this treatment are rare, but hypokalemia in the setting of GM-CSF therapy has recently been described (3). We report a case of acute hypocalcemia and hypomagnesemia causing tetany in a patient with severe aplastic anemia who was treated with human recombinant mammalian glycosylate (rh) GM-CSF (Sandoz-Schering Plouth, Basel, Switzerland).A 4-year-old boy with...References1. Vadhan-RajBuescherBroxmeyer SSH. Stimulation of myelopoiesis in patients with aplastic anemia by recombinant human granulocyte-macrophage colony stimulating factor. N Engl J Med. 1988;319:1628-34. CrossrefMedlineGoogle Scholar2. NissenTichelliGratwohl CAA. Failure of recombinant human granulocyte-macrophage colony stimulating factor therapy in aplastic anemia patients with very severe neutropenia. Blood. 1988; 72:2045-7. CrossrefMedlineGoogle Scholar3. ViensThyssGarnierAyelaLagrangeSchneider PAGPMM. GM-CSF treatment and hypokalemia [Letter]. Ann Intern Med. 1989; 111:263. LinkGoogle Scholar4. DaviesMurrayAmphotericin SJB. aminoglycosides and hypomagnesaemic tetany. Br Med J. 1986;292:1395-6. CrossrefMedlineGoogle Scholar5. BartonPahlVaziriCesario CMNT. Renal magnesium wasting associated with amphotericin B therapy. Am J Med. 1984;77:471-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bristol Royal Hospital for Sick Children Bristol BS2 8BJ United Kingdom PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOsteocyte BiologyGranulocyte–macrophage colony-stimulating factor (GM-CSF)Advances in the treatment of idiopathic pulmonary fibrosisCYTOKINES AND CYTOKINE MODULATORSGranulocyte–macrophage colony-stimulating factor (GM-CSF)Phase I Trial of Etoposide, Carboplatin, and GM-CSF in Extensive Small-Cell Lung CancerBlood and blood products 1 May 1990Volume 112, Issue 9Page: 715-715KeywordsAplastic anemiaGranulocyte macrophage colony stimulating factorHypocalcemiaHypomagnesemiaNeutropenia Issue Published: 1 May 1990 PDF downloadLoading ...
A SIMPLIFIED METHOD FOR DETERMINATION OF THE SPECIFIC GRAVITY OF A FEW DROPS OF URINE
Authors: John Kirkpatrick
Journal: JAMA (1926)

Estimating the specific gravity of a few drops of urine has always been a difficult problem. This difficulty arises more particularly during ureteral catheterization, when only a few drops of urine can be obtained. By the method described here, the specific gravity of a few drops of urine from each kidney can be determined. It will be found applicable in estimating the specific gravity of small samples of voided urine. This method for the determination of the specific gravity of urine is made possible by the utilization of a non-water-soluble mixture. We use for this purpose a mixture of a high specific gravity chemical (carbon tetrachloride), and a low one (xylene). It can be prepared quickly and cheaply from materials ordinarily at hand in the laboratory. Hammerschlag<sup>1</sup>has adapted this principle to determine the specific gravity of blood. But he has used a mixture of chloroform and benzine.
Plaque Neovascularization Is Increased in Ruptured Atherosclerotic Lesions of Human Aorta
Authors: Pedro R. Moreno, K. Raman Purushothaman, Valentin Fuster, Dario Echeverri, Helena Truszczynska, Samin K. Sharma, Juan J. Badimon, William N. O’Connor
Journal: Circulation (2004)

Growth of atherosclerotic plaques is accompanied by neovascularization from vasa vasorum microvessels extending through the tunica media into the base of the plaque and by lumen-derived microvessels through the fibrous cap. Microvessels are associated with plaque hemorrhage and may play a role in plaque rupture. Accordingly, we tested this hypothesis by investigating whether microvessels in the tunica media, the base of the plaque, and the fibrous cap are increased in ruptured atherosclerotic plaques in human aorta.Microvessels, defined as CD34-positive tubuloluminal capillaries recognized in cross-sectional and longitudinal profiles, were quantified in 269 advanced human plaques by bicolor immunohistochemistry. Macrophages/T lymphocytes and smooth muscle cells were defined as CD68/CD3-positive and alpha-actin-positive cells. Total microvessel density was increased in ruptured plaques when compared with nonruptured plaques (P=0.0001). Furthermore, microvessel density was increased in lesions with severe macrophage infiltration at the fibrous cap (P=0.0001) and at the shoulders of the plaque (P=0.0001). In addition, microvessel density was also increased in lesions with intraplaque hemorrhage (P=0.04) and in thin-cap fibroatheromas (P=0.038). Logistic regression analysis identified plaque base microvessel density (P=0.003) as an independent correlate to plaque rupture.Thus, neovascularization as manifested by the localized appearance of microvessels is increased in ruptured plaques in the human aorta. Furthermore, microvessel density is increased in lesions with inflammation, with intraplaque hemorrhage, and in thin-cap fibroatheromas. Microvessels at the base of the plaque are independently correlated with plaque rupture, suggesting a contributory role for neovascularization in the process of plaque rupture.
Immunostimulatory DNA inhibits IL-4–dependent IgE synthesis by human B cells
Authors: Anthony A. Horner, George F. Widhopf, Jan A. Burger, Kenji Takabayashi, Nadya Cinman, Arash Ronaghy, Hans L. Spiegelberg, Eyal Raz
Journal: Journal of Allergy and Clinical Immunology (2001)
Corticosteroids contribute to muscle weakness in chronic airflow obstruction.
Authors: M Decramer, L M Lacquet, R Fagard, P Rogiers
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Twenty-one patients with chronic obstructive pulmonary disease (COPD) or asthma, admitted to our division because of exacerbation of their conditions and requiring intensified treatment with corticosteroids, underwent pulmonary function tests, tests of respiratory muscle function, measurement of quadricep strength, and a variety of anthropometric and biochemical measurements. All tests were performed the 10th day after admission. As expected, muscle strength and pulmonary function were interrelated. Surprisingly, the average daily dose of steroids taken in the previous 6 mo, which ranged from 1.4 to 21.3 mg (average 4.3 mg), was significantly related to inspiratory muscle strength (PImax) and a similar tendency was present for expiratory muscle strength (PEmax). Multiple regression analysis of the relationship between PImax and quadriceps force (QF) and steroid dose revealed that the average daily dose independently explained 32% of the variance in PImax and up to 51% of the variance in QF. These relationships were independent of the degree of bronchial obstruction estimated by percentage predicted FEV1. Other significant determinants were age, sex, and COPD for PImax and age, sex, and body weight for QF. The present study demonstrates that in patients with COPD or asthma, respiratory and peripheral muscle strength and steroid treatment are interrelated despite the relatively low doses administered. This observation imposes further limitations on the prolonged treatment of chronic airflow obstruction with systemic corticosteroids.
ECHOCARDIOGRAPHY ASSESSMENT OF THE IMPACT OF BEVACIZUMAB ON SYSTOLIC AND DIASTOLIC FUNCTION OF LEFT VENTRICLE IN PATIENTS WITH METASTATIC CANCER
Authors: Archontoula Michelongona, Konstantinos Toutouzas, Andreas Synetos, Eleftherios Tsiamis, Ioannis Kapelakis, Flora Zagouri, Aristotle Bamias, Meletios Athanasios Dimopoulos, Stella Kyvelou, Dimitris Tousoulis, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2012)
An off beat whale hunt.
Authors: F. L. Meijler
Journal: BMJ (1989)

The grey whale, Eschrichtius robustus (fig 1), is a fascinating animal that lives for 30-40 years.The numbers of grey whales have increased since the ban on Mipation killing them and there are now about 20000 in * Grey whales travel 10 OOOOkm twice a year existence.They stay in the Bering Sea in May and June .Each trip takes six to eight weeks and then migrate to the lagoons on the Pacific coast of 'They seep wih thei heads *, Duing~the journey they swim for 20 hours a da'y Baja California, Mexico.Theysleep with their heads' and cover a distance of about 150 km and tails down, holding their blow holes above water (fig 2).Mating occurs in the shallow waters and strong,
Hypoxia-inducible factor-1α induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition
Authors: Shiren Sun, Xiaoxuan Ning, Yanqi Zhang, Yuanyuan Lu, Yongzhan Nie, Shuang Han, Lili Liu, Rui Du, Lin Xia, Lijie He, Daiming Fan
Journal: Kidney International (2009)
1033 COMBINATION THERAPY WITH TRANSARTERIAL CHEMOEMBOLIZATION AND RADIOFREQENCY ABLATION COMPARED WITH TRANSARTERIAL CHEMOEMBOLIZATION OR RFA FOR EARLY HEPATOCELLULAR CARCINOMA
Authors: J.H. Kwon, M.J. Song, D.S. Song, H.Y. Kim, S.H. Yoo, C.-H. Park, S.H. Bae, J.Y. Choi, S.K. Yoon, Y.S. Lee, C.D. Lee
Journal: Journal of Hepatology (2012)
Remodeling of Human Coronary Arteries Undergoing Coronary Angioplasty or Atherectomy
Authors: Takeshi Kimura, Satoshi Kaburagi, Takashi Tamura, Hiroyoshi Yokoi, Yoshihisa Nakagawa, Hiroatsu Yokoi, Naoya Hamasaki, Hideyuki Nosaka, Masakiyo Nobuyoshi, Gary S. Mintz, Jeffery J. Popma, Martin B. Leon
Journal: Circulation (1997)

Recently, long-term constriction of the vessel has been suggested as an alternative mechanism of restenosis after coronary angioplasty.To understand remodeling of human coronary arteries undergoing coronary angioplasty or atherectomy, serial intravascular ultrasonographic examinations were performed at preintervention and postintervention examinations and at 24 hours, 1 month, and 6 months. Complete serial data were obtained in 61 lesions (balloon angioplasty, 35 lesions; directional atherectomy, 26 lesions). Lumen area improved from 6.81+/-2.24 mm2 after intervention to 8.22+/-2.79 mm2 at 1 month (P=.0001) and decreased to 4.88+/-2.86 mm2 at 6 months (P=.0001). Vessel area enlarged from 17.32+/-5.35 mm2 after intervention to 19.39+/-5.33 mm2 at 1 month (P=.0001) and decreased to 16.33+/-5.54 mm2 at 6 months (P=.0001). Plaque+media area increased significantly from postintervention examination to 24 hours (10.51+/-4.38 versus 10.96+/-4.49 mm2, P=.0008) and from 24 hours to 6 months (10.96+/-4.49 versus 11.45+/-4.45 mm2, P=.03). Changes in lumen area in each study interval correlated more closely with changes in vessel area than with changes in plaque+media area. Restenotic lesions compared with nonrestenotic lesions had a greater decrease in the vessel area between 1 month and 6 months (-4.33+/-2.73 versus -2.49+/-2.15 mm2, P=.006) and greater increase in the plaque+media area both within 24 hours (0.84+/-1.22 versus 0.27+/-0.38 mm2, P=.04) and between 24 hours and 6 months (1.19+/-2.19 versus 0.18+/-1.46 mm2, P=.04). CONCLUSIONS; Remodeling after coronary angioplasty or atherectomy was characterized by early adaptive enlargement and late constriction of the vessel.
Educating the consumer
Authors: G. Dunea
Journal: BMJ (2003)

How strange that some people still object to how prominent doctors, excellent pharmaceutical companies, and prestigious hospitals educate the public on radio and television. After all, more than 25 years have passed since the US Supreme Court refused (in its Goldfarb decision) to distinguish between so called learned professions and other trades, followed by the Federal Trade Commission's ruling that the American Medical Association violated antitrust laws by banning advertising …
RESUSCITATION IN DEATH UNDER ANAESTHESIA
Authors: W. E. Fisher
Journal: BMJ (1920)

T i, 01 I AfXDIECAZ JOUM"~~~~~~~~~~~~~ free irnn reaction.The spleen contained pigment in leuco- cytes snd erndothelial cells and also free.The kidneys showed some pigment, probably malarial, in some of the glomerular capillaries.The tubules were catarrhal and contained much broken-down material, evidenitly consisting of partially dis- integrated red corpuscles.There were also numerous casts.