tbuckley/cabot-search huggingface dataset:
Home Care for the Aged
Authors: DAVID MUMFORD
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 July 1975Home Care for the AgedDAVID MUMFORD, M.D., IRENE BOGDAN, R.N., ELIZABETH HOYT, M.D., ROSA RODRIGUEZ, M.D.DAVID MUMFORD, M.D.Search for more papers by this author, IRENE BOGDAN, R.N.Search for more papers by this author, ELIZABETH HOYT, M.D.Search for more papers by this author, ROSA RODRIGUEZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-1-125 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Doctor Brickner and his team deserve congratulations for organizing the program described in the January 1975 issue of the Annals. He is incorrect, however, in his statement on page 5 that other "programs either lack a full range of professional health services, limit their patients to those with particular health problems, or have other restrictions." In addition, on page 6, he claims to be unaware of programs designed to seek out and deliver a full range of professional health services to homebound, socially isolated older people hidden in the community.For the benefit of Dr. Brickner and...Reference1. SOMERSBRYANT AN: Home care: much needed, much neglected. Ann Intern Med 82:111-112, 1975 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID MUMFORD, M.D.; IRENE BOGDAN, R.N.; ELIZABETH HOYT, M.D.; ROSA RODRIGUEZ, M.D.Affiliations: Organization of Home Health Agencies New York City Health and Hospitals Corporation Coney Island Hospital Brooklyn, New York 11235 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1975Volume 83, Issue 1Page: 125-126KeywordsMedical services ePublished: 1 December 2008 Issue Published: 1 July 1975 PDF downloadLoading ...
Membrane properties and esterase activity of synovial lining cells: further evidence for a mononuclear phagocyte subpopulation.
Authors: J.C Edwards, A.D Sedgwick, D.A Willoughby
Journal: Annals of the Rheumatic Diseases (1982)

Recent work in our laboratory with mouse radiation chimeras suggests that the macrophage type of synovial lining cell is derived from bone marrow. Further evidence for including this cell type in he mononuclear phagocyte system is now presented. Rosette formation with IgG coated sheep red cells, immunofluorescent staining for surface Ia antigens, and nonspecific esterase staining all show the presence in the synovial lining of a subpopulation of cells carrying these markers. The proportion of such cells in the lining is very variable, as is the proportion of 9type A9 cells recognised with the electron microscope.
A Guide to Dermatohistopathology
Authors: William A. Caro
Journal: JAMA (1976)

The second edition has been expanded and updated. The authors have based the Guide on their own extensive personal experiences and interpretations and not on an exhaustive literature review. The book is organized by histopathological similarities rather than by clinical groupings. The first section covers normal anatomy of the skin, tissue techniques from the proper method of performing a skin biopsy through the preparation and staining of the resulting slide, and various pitfalls and how to avoid them. The next sections discuss histopathology under rather broad groupings, ie, eczematous tissue reactions, psoriasiform tissue reactions, and granulomatous reactions. These sections often include discussions of underlying biological changes that produce the morphologic features observed by the pathologist. A final section covers lesions of mucous membranes, hair, and nails.  The discussions of basic reaction patterns and biological changes form the strongest portions of this book. Individual histopathologic descriptions often are too brief to
Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor
Authors: Makoto Miyara, Yumiko Yoshioka, Akihiko Kitoh, Tomoko Shima, Kajsa Wing, Akira Niwa, Christophe Parizot, Cécile Taflin, Toshio Heike, Dominique Valeyre, Alexis Mathian, Tatsutoshi Nakahata, Tomoyuki Yamaguchi, Takashi Nomura, Masahiro Ono, Zahir Amoura, Guy Gorochov, Shimon Sakaguchi
Journal: Immunity (2009)
Ongoing outbreak of hepatitis A in Italy: preliminary report as of 31 May 2013
Authors: C Rizzo, V Alfonsi, R Bruni, L Busani, A R Ciccaglione, D De Medici, S Di Pasquale, M Equestre, M Escher, M C Montaño-Remacha, G Scavia, S Taffon, V Carraro, S Franchini, B Natter, M Augschiller, M E Tosti, Collective the Central Task Force on Hepatitis A
Journal: Eurosurveillance (2013)

Since January 2013, an unusual increase in hepatitis A cases has been detected in northern Italy. A total number of 352 cases were reported to the integrated surveillance system between January and the end of May 2013 and this represents a 70% increase compared to the same period of the previous year. The outbreak is ongoing and the public health authorities are continuing their investigations to establish the transmission vehicle and to control the outbreak.
Congenital Malformation in Strain A Mice
Authors: Joseph A. DiPaolo
Journal: JAMA (1963)

PHOCOMELIA, a congenital malformation that involves nondevelopment of the long bones of one or more of the extremities, occurs only rarely. Recently, Kosenow and Pfeiffer<sup>1</sup>and Wiedemann<sup>2</sup>reported an increased incidence of phocomelia in the human newborn after use of the sedative thalidomide during early pregnancy. The congenital defects observed under these conditions have been of the most severe types, frequently involving all extremities. Even when the extremities are relatively normal, the prehensile grasp may be lost.<sup>3</sup> Difficulties have been encountered in producing such defects with thalidomide in laboratory animals. Studies with thalidomide in rats caused no malformations,<sup>4-6</sup>although other studies indicate that the substance passes through the placenta in rabbits.<sup>7</sup>According to two reports,<sup>6,8</sup>it produces in rabbits abnormalities which are similar to those found in human infants. Recently, abnormalities consisting of harelip, cleft palate, cataracts, and tail deformities have been found as
Attitudes to questioning in clinical practice may be changed
Authors: M. C J Rudolf, K. Jones
Journal: BMJ (1998)

EDITOR—Barrie and Ward suggest that a major barrier to the promotion of evidence based health care is the generation of questions by the doctor. 1 2 The figure of only 2.4 questions asked per 10 patients should not astonish those who received a conventional medical education taught by authoritarian seniors in an atmosphere where questioning is not fostered.

While running a course on evidence based child health at Leeds University we collected data that suggest that questioning …
Reduced prevalence of impaired glucose tolerance and no change in prevalence of diabetes despite increasing BMI among Aboriginal people from a group of remote homeland communities.
Authors: K G Rowley, A Gault, R McDermott, S Knight, T McLeay, K O'Dea
Journal: Diabetes Care (2000)

OBJECTIVE: To examine trends in glucose tolerance and coronary risk among Aboriginal people from a group of homeland communities in central Australia during a 7-year follow-up period. RESEARCH DESIGN AND METHODS: Community-based screenings of adult volunteers were performed in 1988 (n = 437; 93% response rate) and in 1995 (n = 424; 85% response rate). A health promotion intervention program commenced after the 1988 survey that focused on the benefits of exercise and appropriate diet. RESULTS: Mean (95% CI) BMI increased significantly from 22.8 kg/m2 (22.3-23.2) to 24.2 kg/m2 (23.8-24.7) during the follow-up period (P &amp;lt; 0.001). This increase was similar for men and women and across all age-groups. The increase in BMI was greater among subjects residing adjacent to a store compared with those residing in communities located far from a store (P &amp;lt; 0.001). Decreases were evident in the prevalence of impaired glucose tolerance (IGT) (from 22.5 to 10.1% among women, P &amp;lt; 0.001; from 12.2 to 6.5% among men, P = 0.074) and hypercholesterolemia (from 36.7 to 25.8% among women, P &amp;lt; 0.01; from 52.4 to 44.0% among men, P = 0.147), but no change was evident in the prevalence of diabetes. Smoking remained rare among women (&amp;lt;4%) and decreased among men (from 52.9 to 40.8%, P &amp;lt; 0.05). CONCLUSIONS: The trends in glucose intolerance were clearly better than have been observed in other Aboriginal communities. The institution of an intervention program corresponded with reductions in the prevalence of IGT, hypercholesterolemia, and smoking. The prevalence of diabetes remained unaltered despite a significant increase in mean BMI, possibly because of the promotion of increased physical activity levels.
Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells
Authors: Letizia Venturini, Karin Battmer, Mirco Castoldi, Beate Schultheis, Andreas Hochhaus, Martina U. Muckenthaler, Arnold Ganser, Matthias Eder, Michaela Scherr
Journal: Blood (2007)
German experts question efficacy of expensive new cancer drugs
Authors: A. Tuffs
Journal: BMJ (2010)

German healthcare experts have called for an independent committee to control the introduction of new cancer drugs to the market reports an article in Der Spiegel, 17 May 2010.

A leaked confidential report submitted to the German health ministry by five healthcare experts, spearheaded by health economist Gerd Glaeske from Bremen University, indicates that the price of new cancer drugs should be linked to proof that they work in normal clinical settings rather than in clinical trials of selected patient groups—the current criterion for marketing authorisation. 

The German equivalent of the …
Correction of neutrophil chemotaxis defect in patients with gaucher disease by low‐dose enzyme replacement therapy
Authors: A. Zimran, A. Abrahamov, M. Aker, Y. Matzner
Journal: American Journal of Hematology (1993)

Abstract We have recently described a chemotactic defect in severely afflicted Gaucher disease patients. Two of the patients were treated with low‐dose intravenous enzyme replacement (Ceredase). Marked improvement in their hematological status, organomegaly, and growth was observed. In addition, their chemotactic defect and their tendency towards infections were corrected within 1 year of treatment.
AN APPROACH TO THE QUANTITATION OF IMMUNOGENIC ANTIGEN
Authors: Patricia J. McConahey, Jean-Charles Cerottini, Frank J. Dixon
Journal: The Journal of Experimental Medicine (1968)

Using passively administered isotope-labeled anti-KLH to suppress the antibody response of rabbits to KLH, we have attempted to estimate the amount of antigen actually involved in stimulating antibody formation. Single and paired label tracer studies of passively administered anti-KLH IgG indicated that from 0.7 to 2.9 microg were utilized or involved by the antigen in the course of a 90% suppression of the response to 2 mg KLH. Tracer studies of labeled anti-KLH F(ab')(2) fragments revealed the retention of from 2 to 3 microg of these fragments in the entire rabbit during a 60% suppression of the response to 1 mg KLH. Based on previously determined ratios of mixtures of KLH and suppressive amounts of anti-KLH in adjuvant, the antibody utilization data were converted to the probable amount of antigen or immunogen involved. It appears that after an injection of 2 mg of KLH approximately 0.2-0.5 microg of antigen persisted and reacted with antibody given 24 hr later. Since all of this persisting, reactive antigen may not be immunogenic, the above estimate of immunogen is probably high, but may serve to establish upper limits for the amounts of immunogen involved in stimulating antibody formation and provide a meaningful frame of reference for antigen tracer studies.
Prescription of heroin to treatment resistant heroin addicts: Double blinding is not possible
Authors: T. Dehue
Journal: BMJ (2004)

Diagnosis of autism Adequate funding is needed for assessment services2][3] One important additional reason for such provision, which their review does not emphasise, is that well coordinated, multiagency assessment teams for autism spectrum disorders have a better chance of accurately not giving a diagnosis of it.Our multiagency assessment service for autism spectrum disorders has seen 57 patients in the past two years.We request baseline speech and language therapy and (where applicable) educational psychology assessments on the likelihood of autism spectrum disorder in all cases before patients are seen by our team, so as to ensure best use of clinical resources.Despite this approach only 26 patients (46%) deemed to be likely cases of autism spectrum disorder received a positive diagnosis.This is not due to overzealous interpretation of ICD-10 diagnostic criteria (which are increasingly recognised as being in urgent need of review), as we tend, if anything, to err in favour of diagnosis, even if ICD-10 (or DSM-IV) criteria, are not strictly fulfilled.Relevant agencies must receive adequate funding for implementing the national autism plan for children. 3This is to benefit not only the children and their families who are struggling with the often devastating impact of this disorder but also the depressingly high number of children whom, we suspect, will be wrongly, or inaccurately, given diagnoses, if assessment services for autism spectrum disorders do not improve.
Abstract 3173: Identification of miR-4423 as a primate-specific microRNA highly expressed in airway epithelium and associated with lung cancer
Authors: Catalina Perdomo, Joshua Campbell, Joseph Gerrein, Carmen Tellez, Adam Gower, Jessica Vick, Carly Garrison, Christina Anderlind, George R. Jackson, Frank Schembri, Brigitte N. Gomperts, Patrick Hayden, Steven A. Belinsky, Marc E. Lenburg, Marc E. Lenburg, Avrum Spira
Journal: Cancer Research (2012)

Abstract Smoking is a significant risk factor for lung cancer, the leading cause of cancer-related deaths worldwide. Our group has previously shown that epithelial gene expression is altered throughout the airway of smokers and that some of these changes are regulated by microRNAs. Moreover, we have previously identified gene expression differences in cytologically normal bronchial airway epithelial cells between smokers with and without lung cancer that can serve as an early diagnostic biomarker for lung cancer. Here, we use next-generation sequencing of small RNAs to identify novel microRNAs expressed in airway epithelium and associated with lung cancer. We identify miR-4423 as a primate-specific microRNA highly expressed in the airway epithelium. In vitro, the expression of miR-4423 increases as Normal Human Bronchial Epithelial cells are differentiated into mucociliary epithelium at an Air Liquid Interface, while its mRNA targets decrease in expression. Furthermore, the expression of miR-4423 is reduced in lung tumors and in the cytologically normal bronchial airway epithelium of smokers with lung cancer. In gain-of-function experiments, ectopic expression of miR-4423 in lung cancer cell lines resulted in reduced colony formation in soft agar. Taken together, these data support the power of next-generation sequencing in identifying novel cell type- specific transcripts and provides evidence that this newly characterized microRNA may play a role in promoting the differentiation and/or maintenance of airway epithelium, and can reduce anchorage-independent lung cancer cell growth. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3173. doi:1538-7445.AM2012-3173
Clinical Evaluation and Radiotherapeutic Management of Hodgkin's Disease and the Malignant Lymphomas
Authors: Henry S. Kaplan
Journal: New England Journal of Medicine (1968)

THE problems of Hodgkin's disease and, to a lesser extent, the other malignant lymphomas have interested our group at Stanford for nearly 20 years, but systematic investigations have been undertaken only in the last 10 years. During this interval, our conception of the prognosis of Hodgkin's disease and the malignant lymphomas has undergone a dramatic change. Many physicians, myself included, were taught in medical school to believe that Hodgkin's disease is inexorably fatal and that even to think of its cure is absurd. This attitude has gradually given way in the face of recent evidence derived from investigations of the . . .
California's Beleaguered Physician Groups — Will They Survive?
Authors: Thomas Bodenheimer
Journal: New England Journal of Medicine (2000)

The reports of my death are greatly exaggerated.—Mark TwainOn September 2, 1999, the California Medical Association released a highly publicized report entitled, “The Coming Medical Group Failure Epidemic.”1 The report begins, “Mounting evidence collected by the California Medical Association now points to the imminent collapse of a key element in the state's health care delivery sys-tem . . . with as many as 90 percent of . . . physician organizations in the state poised for bankruptcy or closure.”In 1998, the financial collapse of two large physician-practice–management companies, MedPartners and FPA Medical Management, left thousands of California . . .
The BMJ 's ethics committee is open for business
Authors: A. Tonks
Journal: BMJ (2001)

<h3>Abstract</h3> Circular dichroism spectroscopy is a highly sensitive, but low-resolution technique to study the structure of proteins. Combined with molecular modelling or other complementary techniques, CD spectroscopy can provide essential information at higher resolution. To this end, we introduce a new computational method to calculate the electronic circular dichroism spectra of proteins from a structural model or ensemble using the average secondary structure composition and a pre-calculated set of basis spectra. We compared the predictive power of our method to existing algorithms – namely DichroCalc and PDB2CD – and found that it predicts CD spectra more accurately, with a 50% smaller average deviation from the measured CD spectra. Our results indicate that the derived basis sets are robust to experimental errors in the reference spectra and to the choice of the secondary structure classification algorithm. For over 80% of the globular reference proteins, our basis sets accurately predict the experimental spectrum solely from their secondary structure composition. For the remaining 20%, correcting for intensity normalization considerably improves the prediction power. Additionally, we show that the predictions for short peptides and intrinsically disordered proteins strongly benefit from accounting for side-chain contributions and structural flexibility. <h3>Table Of Content Graphics:</h3>
IMPROVING OUR UNDERSTANDING OF THE RELATIONSHIP BETWEEN QT PROLONGATION AND RISK OF TORSADE DE POINTES USING A QUANTITATIVE MODELING APPROACH
Authors: Lars Johannesen, Christine E. Garnett, Shari Targum, Joo-Yeon Lee, Jens Stampe Soerensen, Nitin Mehrotra
Journal: Journal of the American College of Cardiology (2014)
TCT-609 Comparison of one year outcomes in real world patients treated with a polymer free amphilimus eluting coronary stent versus second generation everolimus eluting stents
Authors: Vasileios F. Panoulas, Azeem Latib, Charbel Naim, Charis Costopoulos, Katsumasa Sato, Maurizio Tespili, Alessandro Sticchi, Tadashi Miyazaki, Filippo Figini, Mauro Carlino, Alaide Chieffo, Matteo Montorfano, Cosmo Godino, Alfonso Ielasi, Luca Testa, Francesco Bedogni, Antonio Colombo
Journal: Journal of the American College of Cardiology (2014)
Concurrent double infections of the skin: Phaeohyphomycosis and nocardiosis in a patient with idiopathic thrombocytopenic purpura
Authors: Masakazu Takahara, Shinichi Imafuku, Tetsuo Matsuda, Takeshi Uenotsuchi, Tadahiko Matsumoto, Arvind A. Padhye, Masutaka Furue
Journal: Journal of the American Academy of Dermatology (2005)
Arginine vasopressin potentiates adrenocorticotropin release induced by ovine corticotropin-releasing factor.
Authors: C R DeBold, W R Sheldon, G S DeCherney, R V Jackson, A N Alexander, W Vale, J Rivier, D N Orth
Journal: Journal of Clinical Investigation (1984)

Arginine vasopressin (AVP) stimulates ACTH release in man and acts synergistically with synthetic ovine corticotropin-releasing factor (oCRF) in vitro. This study was designed to examine in man the combined effects of synthetic AVP (10 U intramuscularly) and oCRF (1 micrograms/kg intravenously) on ACTH release. Five normal male volunteers participated in five separate experiments: (a) AVP alone; (b) oCRF alone; (c) AVP followed by oCRF 15 min later; (d) simultaneous AVP and oCRF; and (e) insulin-induced hypoglycemia. Plasma immunoreactive ACTH (IR-ACTH) and IR-cortisol were measured for 4 h after injection of each hormone; basal levels for all subjects were less than or equal to 9 +/- 1.2 pg/ml and 4.9 +/- 0.4 micrograms/dl (mean +/- SE), respectively. AVP and oCRF, when given individually, caused rapid rises in IR-ACTH to similar peak levels of 25 +/- 6.6 and 33 +/- 4.6 pg/ml, respectively. AVP given 15 min before oCRF caused a 2.6-fold potentiation of the oCRF response, with a peak IR-ACTH of 85 +/- 4.6 pg/ml. AVP given at the same time as oCRF produced a fourfold potentiation of the peak IR-ACTH response to 132 +/- 11 pg/ml. These ACTH responses were far greater than those previously observed after 30-fold greater doses of oCRF alone. By way of comparison, insulin-induced hypoglycemia caused a peak IR-ACTH of 169 +/- 20 pg/ml. IR-ACTH returned to base line at 60-90 min after AVP alone, whereas the prolonged effect of oCRF was apparent whether it was given alone or in combination with AVP. The mean peak IR-cortisol responses to AVP, oCRF, and AVP given 15 min before oCRF were similar (16.5 +/- 0.9, 16.4 +/- 2.3, and 18.5 +/- 0.8 micrograms/dl, respectively), but the peak IR-cortisol responses to AVP and oCRF given simultaneously and to insulin-induced hypoglycemia were 1.5 and 1.7 times greater, respectively. IR-cortisol returned to base line within 2-3 h after AVP alone, but remained elevated for at least 4 h after oCRF alone or in combination with AVP. These results indicate that AVP acts synergistically with oCRF to release ACTH in man and suggest that AVP may play a physiologic role in modulating the ACTH response mediated by corticotropin-releasing factor.
Primary Care by the Nurse
Authors: Ann Sullivan Baker
Journal: New England Journal of Medicine (1974)

Health care is inadequate in many communities; yet the full potential of the nurse has not been realized in ambulatory care. There are several reasons for this misuse of talent. The first is that the role of the office or clinic nurse has been viewed mainly as a technical and clerical job, and the emphasis in nursing education, especially hospital-affiliated nursing schools, has been directed toward inpatient care. The visiting nurse, traditionally closest to a primary caretaker, has often shouldered additional responsibilities but has lacked skills in data collection (i.e., history and physical examination) and especially in recording data to . . .