tbuckley/cabot-search huggingface dataset:
Abstract 1160: Novel CSF-1 receptor ligand IL-34 modulates macrophage-breast cancer cell crosstalk
Authors: Sandun Gunawardhana, Karin Zins, Trevor Lucas, Dietmar Abraham
Journal: Cancer Research (2014)

Abstract Crosstalk between stromal cells and malignant cells within the tumor microenvironment is important for tumorigenesis. According to current clinical and experimental evidence, tumor associated macrophages (TAMs) play a major role in tumor progression to metastasis in different cancers. In breast cancer, increased number of TAMs is associated with poor prognosis. Previous work in our laboratory has shown that depletion of TAMs by blocking colony-stimulating factor-1 (CSF-1) suppresses tumor growth, matrix metalloprotease production and further recruitment of macrophages in a MCF-7 breast cancer xenograft model. In this study, we aim to investigate Interleukin-34 (IL-34), a novel ligand for the colony stimulating factor-1 receptor (CSF-1R). IL-34 functions as a specific and independent ligand and as an agonist to the CSF-1R. Furthermore it is known to induce proliferation through mitogen activated protein kinase (MAPK) activation in macrophages and cancer cells. To date, nothing is known about the role of IL-34 in breast cancer and its effects on downstream signalling pathway modulation in cancer cell-macrophage crosstalk. Our real-time PCR data shows that in co-cultures with murine macrophages, human MCF-7 and MDA-MB-231 breast cancer cells express increased levels of IL-34. In addition, in vitro migration assays demonstrated that recombinant human and murine IL-34 significantly increases the migration of murine macrophages, MCF-7 and MDA-MB-231 breast cancer cells. IL-34 also increased the proliferation of murine macrophages and breast cancer cells. Experiments on the protein level demonstrated the activation of MAPK/ERK in murine macrophages and breast cancer cells by recombinant IL-34. These preliminary data indicate that TAM-breast cancer cell interactions induce IL-34 production associated with induction of proliferation and the migratory capacity of tumor and stromal cells, which together may influence the invasiveness of the developing tumor. Here we propose IL-34 as a target for the treatment of breast cancer which may affect the accumulation of TAMs and improve breast cancer prognosis. Citation Format: Sandun Gunawardhana, Karin Zins, Trevor Lucas, Dietmar Abraham. Novel CSF-1 receptor ligand IL-34 modulates macrophage-breast cancer cell crosstalk. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1160. doi:10.1158/1538-7445.AM2014-1160
DILAUDID AND MORPHINE EFFECTS ON BASAL METABOLISM AND OTHER BODY FUNCTIONS
Authors: NORMAN A. DAVID
Journal: JAMA (1934)

Dilaudid (dihydromorphinone hydrochloride), a new morphine derivative,1was first introduced into this country from Germany in 1932 by Alvarez.2Eddy3has reviewed the foreign literature and reported preliminary experimental studies of the toxicity and action of this drug in animals. Paine, Carlson and Wangensteen4used dilaudid in the treatment of nineteen patients and considered it effective in controlling pain but not superior to morphine in decreasing the incidence of postoperative distention, nausea and vomiting. Diehl,5in his study on the medicinal treatment of the common cold, found a combination of dilaudid and papaverine as efficient as the codeine-papaverine preparation which he recommends but more likely to produce undesirable side-effects.  The chief advantages claimed for dilaudid over morphine are that its repeated use has less tendency to produce habit formation and that there are fewer unfavorable side-effects, such as nausea, constipation and euphoria.6Eddy,3
Nonsteroidal Drugs 2010
Authors: Joseph Tokaruk
Journal: Annals of Internal Medicine (1989)

Ad Libitum15 September 1989Nonsteroidal Drugs 2010Joseph Tokaruk, MDJoseph Tokaruk, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-6-546 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn struts the drug representative, a resplendently attired proselytizer. The only thing missing is a top hat from which to pull the rabbit the beaming doctor is about to see.Rep: (confidently, like a ringmaster) "Doctor, I have a new antiarthritic drug!"Dr:(His smile collapses into a frown, as if he has just discovered that he has to undergo an abdominal aorta repair without an anesthetic.) "I hope you're not going to lecture me about yet another nonsteroidal anti-inflammatory drug. My friend's wife is a pharmacist and she made a dress out of our present plethora of nonsteroidal drugs... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brantford, Ontario PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1989Volume 111, Issue 6Page: 546-546KeywordsAnestheticsAortaDrugsPharmacistsRabbits Issue Published: 15 September 1989 PDF downloadLoading ...
Urticaria in association with etiocholanolone fever
Authors: GUNTER GOERZ, MANFRED BEDBUR, VOLKMAR GRAEF
Journal: British Journal of Dermatology (1981)

Journal Article Urticaria in association with etiocholanolone fever Get access GUNTER GOERZ, GUNTER GOERZ Department of Dermatology, University of Dusseldorf, University of Giessen/Lahn (FRG) Prof. Dr G.Goerz, Department of Dermatology, University of Dusseldorf, Moorenstr. 5 D 4000 Düsseldorf (FRG). Search for other works by this author on: Oxford Academic Google Scholar MANFRED BEDBUR, MANFRED BEDBUR Department of Dermatology, University of Dusseldorf, University of Giessen/Lahn (FRG) Search for other works by this author on: Oxford Academic Google Scholar VOLKMAR GRAEF VOLKMAR GRAEF Department of Clinical Chemistry, University of Dusseldorf, University of Giessen/Lahn (FRG) Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 105, Issue 1, 1 July 1981, Pages 109–112, https://doi.org/10.1111/j.1365-2133.1981.tb00892.x Published: 01 July 1981 Article history Accepted: 24 September 1980 Published: 01 July 1981
A METHOD FOR TITRATING ENDOTOXIC ACTIVITY IN THE SKIN OF RABBITS
Authors: Carl L. Larson, Edgar Ribi, Kelsey C. Milner, Jacob E. Lieberman
Journal: The Journal of Experimental Medicine (1960)

The primary inflammatory response of rabbits to intradermal injection of bacterial products has been used as the basis of a sensitive assay for endotoxins. Injection of materials into the skin of the lateral surfaces, rather than the ventral surface of the abdomen, was essential. The method was evaluated by comparison with the mouse toxicity test. Statistical examination revealed an excellent correlation between the mean threshold dose for producing skin lesions in rabbits (SLD(50)) and the median lethal dose for mice (LD(50)). For potent endotoxins (LD(50) = 0.2-0.3 mg.) the skin test dose was about one-thousandth of the lethal dose for mice. Thereafter the LD(50) increased in the proportion of about 0.3 mg. per 1 microg. increase in SLD(50). The method of testing was devised for endotoxins prepared in various ways from Salmonella enteritidis and S. typhosa but was directly applicable to endotoxins from several other species of enteric Gram-negative bacteria.
High-level expression of Egr-1 and Egr-1–inducible genes in mouse and human atherosclerosis
Authors: Timothy A. McCaffrey, Chenzhong Fu, Baoheng Du, Sukru Eksinar, K. Craig Kent, Harry Bush, Karl Kreiger, Todd Rosengart, Myron I. Cybulsky, Eric S. Silverman, Tucker Collins
Journal: Journal of Clinical Investigation (2000)

To understand the mRNA transcript profile in the human atherosclerotic lesion, RNA was prepared from the fibrous cap versus adjacent media of 13 patients undergoing carotid endarterectomy. cDNA expression arrays bearing 588 known genes indicated that lesions express unexpectedly high levels of the early growth response gene, Egr-1 (NGFI-A), a zinc-finger transcription factor that modulates a cluster of stress-responsive genes including PDGF and TGF-β. Expression of Egr-1 was an average of 5-fold higher in the lesion than in the adjacent media, a result confirmed by RT-PCR, and many Egr-1–inducible genes were also strongly elevated in the lesion. Time-course analyses revealed that Egr-1 was not induced ex vivo. Immunocytochemistry indicated that Egr-1 was expressed prominently in the smooth muscle–actin positive cells, particularly in areas of macrophage infiltration, and in other cell types, including endothelial cells. Induction of atherosclerosis in LDL receptor-null mice by feeding them a high-fat diet resulted in a progressive increase in Egr-1 expression in the aorta. Thus, induction of Egr-1 by atherogenic factors may be a key step in coordinating the cellular events that result in vascular lesions.
SIMPLE ELECTRIC ATTACHMENT FOR OPHTHALMOSCOPE
Authors: M. H. Todd
Journal: JAMA (1913)

The electric ophthalmoscope is very much more convenient than the ordinary type—especially when the patient is in bed—but the cost is excessive in comparison with the convenience, from the point of view of the average physician. I have devised a very simple attachment for the usual form of instrument, which can easily be made for less than a dollar. The necessary materials are a piece of sheet brass as thick as a postcard, and about 6 inches square to allow for errors; a small electric light of the sort used in the familiar hand flash-light, together with its battery; a small mirror, and 3 feet of double flexible electric-wire cord. The tools required are the following: A pair of old shears; a small pair of pliers with quite narrow flat nose, and either a very thin small flat file or, much better, the use for half an hour of
Primary hepatocyte culture supports hepatitis C virus replication: A model for infection-associated hepatocarcinogenesis
Authors: Krishna Banaudha, Jan M. Orenstein, Tamara Korolnek, Georges C. St. Laurent, Takaji Wakita, Ajit Kumar
Journal: Hepatology (2010)

Analysis of progressive changes in hepatic gene expression that underlie hepatocarcinogenesis following hepatitis C virus (HCV) infection require examination of long-term cultures of normally differentiating primary human hepatocytes. We report a culture system of primary hepatocytes that support productive replication of infectious HCV. Hepatic functions were analyzed by reverse-transcription polymerase chain reaction amplification of total cell RNA from cultures maintained in serum-free defined medium for up to 190 days. Sustained hepatic function was assessed by expression of albumin, alpha-fetoprotein, cytochrome P4502E1, cytokeratin-18, type-1 collagen, transforming growth factor-beta 1, matrix metalloproteinase-2 (MMP-2), MMP-13, and interferon alpha-receptors 1 and 2. Normally differentiated human primary hepatocytes supported productive replication of infectious clones of HCV genotypes 1a, 1b, and 2a; virus infection was inhibited by antibodies against CD81 virus entry factor. Virus released into the culture media of HCV-infected primary hepatocytes repeatedly passage to naïve hepatocytes. Replication of the three HCV genotypes shows interferon sensitivity observed in natural infections. Conclusion: Sustained cultures of physiologic host cells for the propagation of infectious HCV strains should accelerate studies of host response to HCV infection and progressive liver disease. Hepatology 2010;51:1922–1932
Bronchiolitis obliterans organising pneumonia in patients taking acebutolol or amiodarone.
Authors: P Camus, J N Lombard, M Perrichon, F Piard, J C Guerin, F B Thivolet, L Jeannin
Journal: Thorax (1989)

Two patients, treated with acebutolol and amiodarone respectively, developed a disease clinically, radiologically, and pathologically indistinguishable from bronchiolitis obliterans organising pneumonia. In one case recovery followed discontinuation of acebutolol; in the other case cessation of amiodarone had no effect, and corticosteroids were required. In addition to these patients, several cases of bronchiolitis obliterans organising pneumonia have been reported during treatment with gold salts, amiodarone, and miscellaneous other drugs. Taken together, this information supports the view that bronchiolitis obliterans organising pneumonia may be a form of response by the lungs to insult by drugs.
Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI
Authors: Weifeng Xu, Bing He, April Chiu, Amy Chadburn, Meimei Shan, Malwina Buldys, Aihao Ding, Daniel M Knowles, Paul A Santini, Andrea Cerutti
Journal: Nature Immunology (2007)
On Acute Anteflexion of the Uterus in the Later Months of Pregnancy
Authors: J. Braithwaite
Journal: BMJ (1894)

As to treatment, quinine, digitalis, antipyrin, etc., seem to be worse than useless, but tepid or cold washing, wlhenever the temperature reaches 1020, is certainly of very great use; ice on the head, milk diet, and a small quantity of stimulants towards the end of the illness have been pre- scribed in my case.I also gave acetate of ammonia, with the view of increasing elimination by the kidneys.
Accumulation of Tc-99m Methylene Diphosphonate in Calcified Metastatic Lesions of the Liver from Colonic Carcinoma
Authors: MICHIO SENDA, NAGARA TAMAKI, KANJI TORIZUKA, YUMIKO FUJIWARA, MASATOSHI KUDO, HITOSHI TOCHIO, HIDETOMI ITO, HARUJI YAMAGUCHI, YASUHIKO SAIKI, KATSUJI IKEKUBO
Journal: Clinical Nuclear Medicine (1985)

Abnormal accumulation of Tc-99m MDP in two metastatic lesions of the liver was observed in a patient with resected colon carcinoma. Single-photon emission computed tomography (SPECT) revealed characteristic marginal accumulation of Tc-99m MDP in both of those metastatic lesions. X-ray CT showed the corresponding marginal calcification in one of the metastases, but no apparent calcification was observed in the other lesion. Two months later, however, the latter also became calcified on x-ray CT. These findings suggest that the accumulation of Tc-99m MDP in the present case is strongly related to the calcium deposition and that Tc-99m MDP may accumulate in a calcified metastatic lesion before the calcification appears on x-ray CT.
Detection of T lymphocytes with a second-site mutation in skin lesions of atypical X-linked severe combined immunodeficiency mimicking Omenn syndrome
Authors: Taizo Wada, Masahiro Yasui, Tomoko Toma, Yuko Nakayama, Mika Nishida, Masaki Shimizu, Michiko Okajima, Yoshihito Kasahara, Shoichi Koizumi, Masami Inoue, Keisei Kawa, Akihiro Yachie
Journal: Blood (2008)
Long noncoding RNAs associated with liver regeneration 1 accelerates hepatocyte proliferation during liver regeneration by activating Wnt/β-Catenin signaling
Authors: Dan Xu, Fu Yang, Ji-hang Yuan, Ling Zhang, Hai-shan Bi, Chuan-chuan Zhou, Feng Liu, Fang Wang, Shu-han Sun
Journal: Hepatology (2013)

In recent years, long noncoding RNAs (lncRNAs) have been investigated as a new class of regulators of biological function. A recent study reported that lncRNAs control cell proliferation in hepatocellular carcinoma (HCC). However, the role of lncRNAs in liver regeneration and the overall mechanisms remain largely unknown. To address this issue, we carried out a genome-wide lncRNA microarray analysis during liver regeneration in mice after 2/3 partial hepatectomy (PH) at various timepoints. The results revealed differential expression of a subset of lncRNAs, notably a specific differentially expressed lncRNA associated with Wnt/ β -catenin signaling during liver regeneration (an lncRNA associated with liver regeneration, termed lncRNA-LALR1). The functions of lncRNA-LALR1 were assessed by silencing and overexpressing this lncRNA in vitro and in vivo . We found that lncRNA-LALR1 enhanced hepatocyte proliferation by promoting progression of the cell cycle in vitro . Furthermore, we showed that lncRNA-LALR1 accelerated mouse hepatocyte proliferation and cell cycle progression during liver regeneration in vivo . Mechanistically, we discovered that lncRNA-LALR1 facilitated cyclin D1 expression through activation of Wnt/β-catenin signaling by way of suppression of Axin1. In addition, lncRNA-LALR1 inhibited the expression of Axin1 mainly by recruiting CTCF to the AXIN1 promoter region. We also identified a human ortholog RNA of lncRNA-LALR1 (lncRNA-hLALR1) and found that it was expressed in human liver tissues. Conclusion : lncRNA-LALR1 promotes cell cycle progression and accelerates hepatocyte proliferation during liver regeneration by activating Wnt/β-catenin signaling. Pharmacological intervention targeting lncRNA-LALR1 may be therapeutically beneficial in liver failure and liver transplantation by inducing liver regeneration. (Hepatology 2013;58:739–751)
Deficiency of thrombin activatable fibrinolysis inhibitor in cirrhosis is associated with increased plasma fibrinolysis
Authors: Mario Colucci, Bianca M. Binetti, Maria G. Branca, Carlo Clerici, Antonio Morelli, Nicola Semeraro, Paolo Gresele
Journal: Hepatology (2003)

Hyperfibrinolysis is thought to contribute to bleeding associated with advanced cirrhosis. Thrombin activatable fibrinolysis inhibitor (TAFI) is a plasma precursor of a carboxypeptidase (TAFIa) with antifibrinolytic activity and was recently shown to be reduced in cirrhosis. In this study, we evaluated the influence of TAFI deficiency on in vitro fibrinolysis in cirrhotic patients. Fifty–three patients with cirrhosis and 43 healthy controls were studied. TAFI antigen was measured by enzyme–linked immunosorbent assay and TAFI activity by chromogenic assay. Fibrinolysis was evaluated as tissue plasminogen activator–induced plasma clot lysis time in the absence and in the presence of a specific inhibitor of TAFIa. TAFI antigen and activity levels were markedly reduced in cirrhotic patients ( P &lt; .0001). In these patients, the lysis time of plasma clots was shorter than in controls (median, interquartile range: 25 minutes, 21–36 minutes vs. 48 minutes, 40–60 minutes, respectively; P &lt; .0001) and was poorly influenced by the TAFIa inhibitor. Accordingly, TAFIa and thrombin activity, generated in cirrhotic samples during clot lysis, were significantly lower than in control samples. Addition of purified TAFI to cirrhotic plasma prolonged the lysis time and enhanced the response to TAFIa inhibitor in a dose–dependent manner. In conclusion, our results indicate that in vitro plasma hyperfibrinolysis in cirrhosis is largely due to a defective TAFIa generation resulting from low TAFI levels and probably from impaired thrombin generation. Impairment of the antifibrinolytic TAFI pathway might contribute to bleeding associated with this disease.
Isolated Visual Symptoms in an Older Woman-Reply
Authors: James Goodwin
Journal: JAMA (1995)

<h3>In Reply.</h3> —I have no disagreement with any of Dr Weintraub's comments. I think the way one approaches this kind of deliberately vague case account depends on one's mind-set at the time of reading. The case lacks so many specific details on so many of the questions we would all have asked the patient in taking the history that it is more of a Rorschach test than a case history. Viewing the problem as one of vertebrobasilar insufficiency would require that the patient have intermittent ischemia of the brain stem many times a week for more than a year. Also, the dependence of the symptoms on shifts of gaze angle would not be easily explained, nor would the cessation of symptoms for more than a week following dilatation of the pupils. Of course, this last could be a red herring. Weintraub notes the relationship of blood flow in the vertebral
UNITED STATES EXPERIENCE WITH ATRIAL FLUTTER ABLATION A STUDY OF TRENDS IN UTILIZATION, DEMOGRAPHIC DISPARITIES AND OUTCOMES USING THE NATIONWIDE INPATIENT SAMPLE DATABASE FOR YEARS 2003-2010
Authors: Arun Raghav Mahankali Sridhar, Madhu Reddy, Arun Kanmanthareddy, Ryan Maybrook, Vivek Yarlagadda, Anand Pillai, Buddhadeb Dawn, Donita Atkins, Sudharani Bommana, Dhanunjaya Lakkireddy
Journal: Journal of the American College of Cardiology (2014)
Peginterferon Alfa-2a and Ribavirin in Latino and Non-Latino Whites with Hepatitis C
Authors: Maribel Rodriguez-Torres, Lennox J. Jeffers, Muhammad Y. Sheikh, Lorenzo Rossaro, Victor Ankoma-Sey, Fayez M. Hamzeh, Paul Martin
Journal: New England Journal of Medicine (2009)

Race has been shown to be a factor in the response to therapy for hepatitis C virus (HCV) infection, and limited data suggest that ethnic group may be as well; however, Latinos and other ethnic subpopulations have been underrepresented in clinical trials. We evaluated the effect of Latino ethnic background on the response to treatment with peginterferon alfa-2a and ribavirin in patients infected with HCV genotype 1 who had not been treated previously.In a multicenter, open-label, nonrandomized, prospective study, 269 Latino and 300 non-Latino whites with HCV infection received peginterferon alfa-2a, at a dose of 180 microg per week, and ribavirin, at a dose of 1000 or 1200 mg per day, for 48 weeks, and were followed through 72 weeks. The primary end point was a sustained virologic response. We enrolled Latinos whose parents and grandparents spoke Spanish as their primary language; nonwhite Latinos were excluded.Baseline characteristics were similar in the Latino and non-Latino groups, although higher proportions of Latino patients were 40 years of age or younger, had a body-mass index (BMI, the weight in kilograms divided by the square of the height in meters) of more than 27 or more than 30, and had cirrhosis. The rate of sustained virologic response was higher among non-Latino whites than among Latinos (49% vs. 34%, P<0.001). The absence of HCV RNA in serum was more frequent in non-Latino whites at week 4 (P=0.045) and throughout the treatment period (P<0.001 for all other comparisons). Latino or non-Latino background was an independent predictor of the rate of sustained virologic response in an analysis adjusted for baseline differences in BMI, cirrhosis, and other characteristics. Adherence to treatment did not differ significantly between the two groups. The numbers of patients with adverse events and dose modifications were similar in the two groups, but fewer Latino patients discontinued therapy because of adverse events.Treatment with peginterferon alfa-2a and ribavirin for 48 weeks resulted in rates of sustained virologic response among patients infected with HCV genotype 1 that were lower among Latino whites than among non-Latino whites. Strategies to improve the sustained virologic response in Latinos are needed. (ClinicalTrials.gov number, NCT00107653.)
Cardiovascular effects of calcitonin gene-related peptides I and II in man.
Authors: A Franco-Cereceda, C Gennari, R Nami, D Agnusdei, J Pernow, J M Lundberg, J A Fischer
Journal: Circulation Research (1987)

Calcitonin gene-related peptide (CGRP) is present in sensory nerve fibers in the heart and around peripheral arteries. On interaction with specific CGRP binding sites and activation of adenylate cyclase, CGRP causes vasodilation and has positive inotropic and chronotropic effects on the heart. In the present study, human CGRP I and II exerted positive inotropic effects on isolated human right auricles and relaxed small arteries from human skeletal muscle precontracted with norepinephrine (EC50 for CGRP I 0.59 nM and for CGRP II 0.37 nM). CGRP I and II (3.2 nmol) administered i.v. to 6 normal subjects exerted positive inotropic actions on the human heart concomitant with positive chronotropic effects, hypotension, and vasodilation. CGRP may, therefore, be of importance for cardiovascular control in man.