“The Older, the Wiser” in Prostate Cancer Treatment Choices?
Authors: Lazzaro Repetto, Angela Marie Abbatecola, Giuseppe Paolisso
Journal: Annals of Internal Medicine (2013)

Editorials21 May 2013“The Older, the Wiser” in Prostate Cancer Treatment Choices?Lazzaro Repetto, MD, Angela Marie Abbatecola, MD, PhD, and Giuseppe Paolisso, MDLazzaro Repetto, MDFrom Sanremo Hospital, Sanremo, Italy; Italian National Research Centre on Aging, Ancona, Italy; and Second University of Naples, Naples, Italy.Search for more papers by this author, Angela Marie Abbatecola, MD, PhDFrom Sanremo Hospital, Sanremo, Italy; Italian National Research Centre on Aging, Ancona, Italy; and Second University of Naples, Naples, Italy.Search for more papers by this author, and Giuseppe Paolisso, MDFrom Sanremo Hospital, Sanremo, Italy; Italian National Research Centre on Aging, Ancona, Italy; and Second University of Naples, Naples, Italy.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-10-201305210-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Prostate cancer has rapidly surpassed lung cancer to become the most common form of cancer in men. The widespread use of the serum prostate-specific antigen (PSA) level for early detection may partially explain this change. In 2012, Siegel and colleagues (1) projected 241 740 new cases of prostate cancer—representing approximately 30% of new cancer diagnoses in men—and 28 170 deaths from the disease. They also estimated the probability of prostate cancer across age groups and found that it jumped from 2.63% (1 in 38) in men aged 40 to 59 years to 6.84% (1 in 15) in those aged 60 to 69 ...References1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62:10-29. [PMID: 22237781] CrossrefMedlineGoogle Scholar2. American Urological Association. Prostate-Specific Antigen Best Practice Statement: 2009 Update. Linthicum, MD: American Urological Association; 2009. Accessed at www.auanet.org/content/media/psa09.pdf on 9 April 2013. Google Scholar3. Smith RA, Cokkinides V, von Eschenbach AC, Levin B, Cohen C, Runowicz CD, et al; American Cancer Society. American Cancer Society guidelines for the early detection of cancer. CA Cancer J Clin. 2002;52:8-22. [PMID: 11814067] CrossrefMedlineGoogle Scholar4. Schaeffer EM, Carter HB, Kettermann A, Loeb S, Ferrucci L, Landis P, et al. Prostate specific antigen testing among the elderly—when to stop? J Urol. 2009;181:1606-14. [PMID: 19246059] CrossrefMedlineGoogle Scholar5. U.S. Preventive Services Task Force. Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2008;149:185-91. [PMID: 18678845] LinkGoogle Scholar6. Droz JP, Balducci L, Bolla M, Emberton M, Fitzpatrick JM, Joniau S, et al. Management of prostate cancer in older men: recommendations of a working group of the International Society of Geriatric Oncology. BJU Int. 2010;106:462-9. [PMID: 20346033] CrossrefMedlineGoogle Scholar7. Albertsen PC, Hanley JA, Fine J. 20-year outcomes following conservative management of clinically localized prostate cancer. JAMA. 2005;293:2095-101. [PMID: 15870412] CrossrefMedlineGoogle Scholar8. Abbatecola AM, Spazzafumo L, Corsonello A, Sirolla C, Bustacchini S, Guffanti E. Development and validation of the HOPE prognostic index on 24-month posthospital mortality and rehospitalization: Italian National Research Center on Aging (INRCA). Rejuvenation Res. 2011;14:605-13. [PMID: 21867411] CrossrefMedlineGoogle Scholar9. Daskivich TJ, Fan KH, Koyama T, Albertsen PC, Goodman M, Hamilton AS, et al. Effect of age, tumor risk, and comorbidity on competing risks for survival in a U.S. population–based cohort of men with prostate cancer. Ann Intern Med. 2013;158:709-17. LinkGoogle Scholar10. Repetto L, Piselli P, Raffaele M, Locatelli C; GIOGer. Communicating cancer diagnosis and prognosis: when the target is the elderly patient-a GIOGer study. Eur J Cancer. 2009;45:374-83. [PMID: 18838268] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Lazzaro Repetto, MD; Angela Marie Abbatecola, MD, PhD; Giuseppe Paolisso, MDAffiliations: From Sanremo Hospital, Sanremo, Italy; Italian National Research Centre on Aging, Ancona, Italy; and Second University of Naples, Naples, Italy.Disclosures: None disclosed. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M13-0898.Corresponding Author: Lazzaro Repetto, MD, Sanremo Hospital, Department of Oncology, Via G Borea, 56, 18038 Sanremo (IM), Italy.Current Author Addresses: Dr. Repetto: Sanremo Hospital, Department of Oncology, Via G Borea, 56, 18038 Sanremo (IM), Italy.Dr. Abbatecola: Italian National Research Center on Aging, Scientific Direction, Via Santa Margherita, 5, 60100 Ancona, Italy.Dr. Paolisso: Second University of Naples, Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Piazza Miraglia, 2, 80138 Naples, Italy. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffect of Age, Tumor Risk, and Comorbidity on Competing Risks for Survival in a U.S. Population–Based Cohort of Men With Prostate Cancer Timothy J. Daskivich , Kang-Hsien Fan , Tatsuki Koyama , Peter C. Albertsen , Michael Goodman , Ann S. Hamilton , Richard M. Hoffman , Janet L. Stanford , Antoinette M. Stroup , Mark S. Litwin , and David F. Penson Prostate Cancer Treatment Choices Andrew M.D. Wolf Prostate Cancer Treatment Choices Lazzaro M. Repetto , Angela Marie Abbatecola , and Giuseppe Paolisso Metrics Cited byProstate Cancer Treatment ChoicesAndrew M.D. Wolf, MD 21 May 2013Volume 158, Issue 10Page: 772-773KeywordsAge groupsCancer risk factorsCancer treatmentGeriatricsHematology and oncologyLung and intrathoracic tumorsMortalityProstate cancerProstate diseasesResearch design ePublished: 21 May 2013 Issue Published: 21 May 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...