tbuckley/cabot-search huggingface dataset:
Transfer Factor: Warning on Uncertainty of Results
Authors: DAVID DRESSLER
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 February 1975Transfer Factor: Warning on Uncertainty of ResultsDAVID DRESSLER, PH.D., HUNTINGTON POTTERDAVID DRESSLER, PH.D.Search for more papers by this author, HUNTINGTON POTTERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-2-279_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Over the last few months we have reported experiments about the existence and nature of "transfer factor." These experiments were done both independently and jointly over a 10-month period by three people (1-3). Our preparation of biologically active material originally occurred with a success rate of 30% (20 successful preparations). More recently, however, since April 1974, no member of the group has been able to prepare active material.This has led us to be concerned that our original positive results may not have been obtained by the procedures described. We leave it to the kindness of our...References1. ROSENFELDDRESSLER SD: Transfer factor: a subcellular component that transmits information for specific immune responses. Proc Natl Acad Sci USA 71:2473-2477, 1974 CrossrefMedlineGoogle Scholar2. DRESSLERROSENFELD DS: On the chemical nature of transfer factor. Proc Natl Acad Sci USA 71:4429-4434, 1974 CrossrefMedlineGoogle Scholar3. POTTERROSENFELDDRESSLER HSD: Transfer factor. Ann Intern Med 81:838-847, 1974 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID DRESSLER, PH.D.; HUNTINGTON POTTERAffiliations: Harvard Biological Laboratories Room 369 Harvard University 16 Divinity Ave. Cambridge, Massachusetts 02138 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInhibitory activity of medium-dialyzed transfer factor on lymphocyte blastogenesis 1 February 1975Volume 82, Issue 2Page: 279-279 ePublished: 1 December 2008 Issue Published: 1 February 1975 PDF downloadLoading ...
Intra-arterial Alprostadil for Nonatherosclerotic Vasculopathy
Authors: D. L. Wooster
Journal: JAMA (1981)

A 33-year-old man with a nonatherosclerotic vasculopathy of undetermined origin had progressive occlusive disease of the lower limb vessels. The resultant severe rest pain and ischemic ulceration of his foot were inoperable and unresponsive to conventional drug therapy. Treatment was begun with intra-arterially administered alprostadil (prostaglandin E<sub>1</sub>), a vasodilator and inhibitor of platelet aggregation. Although immediate benefit was equivocal, his rest pain had disappeared six weeks after infusion, and the ischemic ulcer almost healed completely. Blood flow studies showed increased flow to the feet, consistent with the subjective improvement. The beneficial effect of alprostadil suggests that further studies with this agent are warranted for patients with nonatherosclerotic vasculopathy. (<i>JAMA</i>1981;245:1846-1849)
114 SIRTACE: A RANDOMISED MULTICENTRE PILOT TRIAL OF SELECTIVE INTERNAL RADIOEMBOLISATION (SIRT) WITH YTTRIUM-90 MICROSPHERES VERSUS TRANSARTERIAL CHEMO-EMBOLISATION (TACE) IN PATIENTS WITH UNRESECTABLE HEPATOCELLULAR CARCINOMA (HCC)
Authors: F.T. Kolligs, J.I. Bilbao, T. Jakobs, M. Iñarrairaegui, J. Nagel, M. Rodriguez, A. Haug, D. D'Avola, M. op den Winkel, A. Martinez-Cuesta, C. Trumm, A. Benito, K. Tatsch, C. Zech, R.-T. Hoffmann, B. Sangro
Journal: Journal of Hepatology (2013)
Why are hospital admission and mortality rates for childhood asthma higher in New Zealand than in the United Kingdom?
Authors: E A Mitchell, H R Anderson, P Freeling, P T White
Journal: Thorax (1990)

New Zealand has higher mortality and hospital admission rates for asthma than England and Wales. To determine the reasons for this the available data on asthma mortality and hospital admissions from the Auckland region of New Zealand were compared with data from the South West Thames Region of England for 1979-86 and data from previous surveys on prevalence of wheeze (Auckland 1985, Croydon 1978). In addition, a survey of general practitioners was carried out to determine their approach to the management of asthma, patient simulations being used. Asthma mortality in children of European descent aged 5-14 years was 2.5 times higher in Auckland than in South West Thames. The reported lifetime, 12 month, and one month prevalences of wheeze were also higher in Auckland (by 18.5%, 32.1%, and 87.5%). Unexpectedly, the hospital admission rate for asthma in children of European descent aged 5-14 years was 5% less in Auckland than in South West Thames. Comparative studies of hospital case notes and of the replies from general practitioners showed that in Auckland the duration of illness before admission was greater and that general practitioners were less likely to admit patients with acute asthma. The overall standard of general practitioner care in Auckland was, if anything, higher than in South West Thames but in both areas there was considerable variation. On balance it was concluded that the higher mortality rate in New Zealand is explained by higher levels of morbidity rather than relative deficiencies in care. Nevertheless, the implications of the lesser use of hospital care for acute asthma observed in Auckland need further consideration.
Effects of Naltrexone Sustained-Release/Bupropion Sustained-Release Combination Therapy on Body Weight and Glycemic Parameters in Overweight and Obese Patients With Type 2 Diabetes. Diabetes Care 2013;36:4022-4029
Authors: P. Hollander, A. K. Gupta, R. Plodkowski, F. Greenway, H. Bays, C. Burns, P. Klassen, K. Fujioka
Journal: Diabetes Care (2014)

In the print version of the article listed above, the following sentence should have been …
The book number
Authors: L. S. King
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Presence of high-ERG expression is an independent unfavorable prognostic marker in MLL-rearranged childhood myeloid leukemia
Authors: Martina Pigazzi, Riccardo Masetti, Francesco Martinolli, Elena Manara, Alessandra Beghin, Roberto Rondelli, Franco Locatelli, Franca Fagioli, Andrea Pession, Giuseppe Basso
Journal: Blood (2012)
Effect of seasonal exposure to pollen on nonspecific interleukin‐4, interleukin‐5, and interferon‐gamma <i>in vitro</i> release by peripheral blood mononuclear cells from subjects with pollinosis
Authors: F. J. Muñoz‐Bellido, F. J. Monteseirin, M. M. Escribano, J. Delgado, E. Velázquez, J. Conde
Journal: Allergy (1998)

The immune response to environmental allergens depends on both genetic and environmental factors. Allergen exposure triggers the activation of allergen‐specific Th2 cells in allergic patients, as well as increased Th2‐type cytokine mRNA expression and eosinophil recruitment. Nevertheless, different patterns of release of cytokines could explain the heterogeneity of atopic response. In our study, 25 patients with pollinosis and 15 healthy donors were selected to characterize their release of Th2 (interleukin [IL]‐4 and IL‐5) and Thi (interferon‐gamma [IFN‐y]) cytokines, both during and outside the pollen season. Peripheral blood mononuclear cells from patients and controls were isolated, cultured in the presence of phorbol‐12‐myristate‐13‐ acetate plus ionomycine, and phytohemagglutinin (PHA), and cytokine release was assessed by titration in the supernatants. Both IL‐4 and IL‐5 showed higher levels during than outside the pollen season in pollinic patients (P&lt;0.05) after nonspecific stimuli, whereas IFN‐y levels were significantly lower during than outside the pollen season only after culture with PHA. Significant differences were not observed in the control group. Our results are consistent with the hypothesis that release of cytokines by peripheral blood mononuclear cells from patients with pollinosis depends on environmental exposure to sensitizing pollens, and that influence can be revealed by in vitro nonspecific stimulation. Nevertheless, the heterogeneity in results suggests that the use of mitogens to assess Thl/Th2 dominance may need careful evaluation.
Website of the week: Focus on Afghanistan
Authors: A. Vass
Journal: BMJ (2002)

The media continue to provide detailed coverage and analysis of the situation in Afghanistan. Web coverage extends this further and offers the opportunity of getting information “straight from the horse's mouth.” Discussion forums on all the major search engines — for example, at http://groups.google.com/groups?hl=en&group=soc.culture.afghanistan — also provide the chance to engage in debates over subjects such as: what is the American economic interest in Afghanistan? Can war be justified? Is religion the root of war? How should the current humanitarian crisis be handled?

The main focus of much internet attention is now on reconstruction and the provision of humanitarian aid. In the “reconstructing Afghanistan” area of http://www.worldbank.org/ you can read World Bank news stories and reports on the estimated levels of aid required for reconstruction. You can also access the findings from reconstruction conferences held in Bonn and Tokyo. The UK …
Depressant effect of adenosine in isolated human and canine atrial fibres
Authors: G.-Y. Wang, J. Wei, C.-I Lin
Journal: Cardiovascular Research (1991)

Journal Article Depressant effect of adenosine in isolated human and canine atrial fibres Get access Gern-Yao Wang, Gern-Yao Wang Search for other works by this author on: Oxford Academic PubMed Google Scholar Jeng Wei, Jeng Wei Search for other works by this author on: Oxford Academic PubMed Google Scholar Cheng-I Lin Cheng-I Lin Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 25, Issue 1, January 1991, Pages 31–35, https://doi.org/10.1093/cvr/25.1.31 Published: 01 January 1991 Article history Received: 08 May 1990 Accepted: 18 July 1990 Published: 01 January 1991
Central Venous Catheterization
Authors: Alan S. Graham, Caroline Ozment, Ken Tegtmeyer, Susanna Lai, Dana A.V. Braner
Journal: New England Journal of Medicine (2007)

The placement of a central venous line is an essential technique in the treatment of many hospitalized patients. This video will demonstrate the placement of a central venous catheter in the internal jugular vein with the use of one of several variations of the Seldinger technique. An additional video on subclavian line placement will be forthcoming. We will demonstrate and review the regional anatomy of the neck, indications for the insertion of a central line, the recommended site and technique for placement of a line in the internal jugular vein, selected complications associated with the procedure, and suggestions for . . . .
Clinical and economic arguments favour extension to upper age limit for breast screening
Authors: D. J Torgerson, T. Gosden
Journal: BMJ (1998)

EDITOR—In an editorial Sutton argues that the upper age limit of 64 for breast screening is illogical, and he ascribes it to ageism.1 This may be true, but there is no economic rationale for limiting routine screening to women below the age of 65. Indeed, the most cost effective age in terms of cost per life year saved by breast screening is 70.2 We have recently set out …
Science, medicine, and the future: Virtual reality in surgery
Authors: R. McCloy, R. Stone
Journal: BMJ (2001)

Taurine is an amino acid that plays important roles in maintaining both the structural integrity and function of the retina. Thus, the effects of taurine, taurine analogues, and their combinations were studied in the ATP-dependent calcium ion uptake system at low calcium ion concentrations (10 microM) in a rat retinal membrane preparation. (+/-)-(trans)-2-Aminocyclopentanesulfonic acid (TAPS), a cyclic taurine analogue previously determined to inhibit ATP-dependent calcium ion uptake was demonstrated to be noncompetitive (Ki = 0.055 mM) with respect to taurine, that is, the values for the half-saturation concentrations calculated from varying concentrations of taurine compared with varying concentrations of taurine in the presence of a fixed concentration of TAPS (80 microM) did not change. However, the values for the maximal rates of change were significantly different. 1,2,3,4-Tetrahydroquinoline-8-sulfonic acid (THQS), a less potent inhibitor of ATP-dependent calcium ion uptake than TAPS, was also shown to be noncompetitive with taurine, with an inhibition constant (Ki) of 23.8 mM. Thus, it is presumed that both compounds (TAPS and THQS) are acting at receptor site(s) other than the taurine binding site. When TAPS and THQS were tested in a mixture that maintains a ratio (fixed ratio mixture) of 1 part TAPS and 25 parts THQS (by concentration, in mM), varied over a wide range of concentrations, and were then analyzed by median-effect plots and equation, the inhibitory effects are strongly synergistic, as shown by the combination index and the dose-reduction index. The parallel nature of the median-effect plots of TAPS and THQS indicates that the two inhibitors have a similar mode of action, that is, mutually exclusive. (+/-)-3-Aminotetrahydrothiophene-1,1-dioxide (ATS) and (+/-)-piperidine-3-sulfonic acid (PSA) are an agonist and partial agonist that demonstrated stimulatory effects on ATP-dependent calcium ion uptake. When tested in combination (1:1) with taurine, they were also determined to be mutually exclusive. It was demonstrated that ATS and taurine induced the same maximal rates of change of calcium ion uptake; however, PSA was less potent than taurine. The combination of taurine plus ATS was additive, whereas the combination of taurine plus PSA was synergistic. Structure-activity relationships of the taurine analogues and their topological relationships are discussed.
Strategic planning of acute beds by specialty
Authors: J F Rudge, B W Richards
Journal: BMJ (1979)

<h3>Abstract</h3> The development of CRISPR/Cas9 technologies has dramatically increased the accessibility and efficiency of genome editing in many organisms. In general, <i>in vivo</i> germline expression of Cas9 results in substantially higher activity than embryonic injection. However, no transgenic lines expressing Cas9 have been developed for the major mosquito disease vector <i>Aedes aegypti</i>. Here, we describe the generation of multiple stable, transgenic <i>Ae. aegypti</i> strains expressing Cas9 in the germline, resulting in dramatic improvements in both the consistency and efficiency of genome modifications using CRISPR. Using these strains, we disrupted numerous genes important for normal morphological development, and even generated triple mutants from a single injection. We have also managed to increase the rates of homology directed repair by more than an order of magnitude. Given the exceptional mutagenic efficiency and specificity of the Cas9 strains we built, they can be used for high-throughput reverse genetic screens to help functionally annotate the <i>Ae. aegypti</i> genome. Additionally, these strains represent a first step towards the development of novel population control technologies targeting <i>Ae. aegypti</i> that rely on Cas9-based gene drives. <h3>Significance Statement</h3> <i>Aedes aegypti</i> is the principal vector of multiple arboviruses that significantly affect human health including dengue, chikungunya, and zika. Development of tools for efficient genome engineering in this mosquito will not only lay the foundation for the application of novel genetic control strategies that do not rely on insecticides, but will also accelerate basic research on key biological processes involved in disease transmission. Here, we report the development of a transgenic CRISPR approach for rapid gene disruption in this organism. Given their high editing efficiencies, the Cas9 strains we developed can be used to quickly generate novel genome modifications allowing for high-throughput gene targeting, and can possibly facilitate the development of gene drives, thereby accelerating comprehensive functional annotation and development of innovative population control strategies for <i>Ae. aegypti</i>.
The Intersection of Immune-Directed and Molecularly Targeted Therapy in Advanced Melanoma: Where We Have Been, Are, and Will Be
Authors: Ryan J. Sullivan, Patricia M. LoRusso, Keith T. Flaherty
Journal: Clinical Cancer Research (2013)

Abstract In three years, four drugs have gained regulatory approval for the treatment of metastatic and unresectable melanoma, with at least seven other drugs having recently completed, currently in, or soon to be in phase III clinical testing. This amazing achievement has been made following a remarkable increase of knowledge in molecular biology and immunology that led to the identification of high-valued therapeutic targets and the clinical development of agents that effectively engage and inhibit these targets. The discovery of either effective molecularly targeted therapies or immunotherapies would have led to dramatic improvements to the standard-of-care treatment of melanoma. However, through parallel efforts that have showcased the efficacy of small-molecule BRAF and MAP–ERK kinase (MEK) inhibitors, as well as the immune checkpoint inhibitors, namely ipilimumab and the anti-PD1/PDL1 antibodies (lambrolizumab, nivolumab, MPDL3280), an opportunity exists to transform the treatment of melanoma specifically and cancer generally by exploring rational combinations of molecularly targeted therapies, immunotherapies, and molecular targeted therapies with immunotherapies. This overview presents the historical context to this therapeutic revolution, reviews the benefits and limitations of current therapies, and provides a look ahead at where the field is headed. Clin Cancer Res; 19(19); 5283–91. ©2013 AACR.
O9.08 * END OF LIFE CARE IN HIGH-GRADE GLIOMA PATIENTS IN THREE EUROPEAN COUNTRIES: A COMPARATIVE STUDY
Authors: J. A. F. Koekkoek, L. Dirven, J. C. Reijneveld, H. R. W. Pasman, S. McNamara, W. Grisold, G. Stockhammer, C. Marosi, M. J. B. Taphoorn, J. J. Heimans
Journal: Neuro-Oncology (2014)

OBJECTIVES: Exploring cross-national differences is useful to evaluate whether different patterns of end of life (EOL) care meet patient's specific needs. This study compared the EOL care processes for high-grade glioma (HGG) in three European countries: The Netherlands, Austria and Scotland. Aspects of EOL care associated with good quality of care (QOC) were identified. METHODS: We analyzed 207 questionnaires from relatives of deceased HGG patients, using a similar retrospective study design in three countries, and examined the subthemes: 1) organization of EOL care, such as residence of care, transitions and place of death; 2) treatment preferences; 3) experiences with EOL care; 4) perceived QOC. A multivariate logistic regression was performed to identify independent predictors of good QOC (≥6 on a 7-point Likert scale). RESULTS: Three months before death 75% of patients were at home. In all three countries, on average, 50% was transferred to a hospital at least once and received effective symptom treatment during the last 3mo. In The Netherlands, Austria and Scotland, respectively, home (60%), a hospital (41%) or a hospice (41%) were the most common places where patients died (p < 0.001). Advance directives were present in 46% of the Dutch, 36% of Scottish and 6% of Austrian patients (p < 0.001). Fifty-three percent of patients experienced good QOC, irrespective of country. Dying at the preferred place, satisfaction with information provided and effective symptom treatment were independently associated with good QOC. CONCLUSION: There are remarkable cross-national differences in organization and experiences with EOL care for HGG, although patient's perceived QOC is similar in the three countries. As symptom treatment was considered effective in only half of all HGG patients, and independently predicted good QOC, this particularly needs further improvement in all countries.
Outpatient Intravenous Antibiotic Therapy
Authors: Peter T. Frame
Journal: JAMA (1982)

In this issue (p 336), Poretz et al report the largest published series of patients treated with intravenous (IV) antibiotics as outpatients. Their experience closely parallels that of previous reports that document the efficacy, safety, and cost savings of this form of therapy.<sup>1-3</sup> In each of the published series, bone and joint infections predominate, with occasional cases of endocarditis and other deep-seated infections. Long-term follow-up is not provided in the article by Poretz and co-workers, but short-term efficacy was clearly demonstrated. Factors that might affect the efficacy of antibiotic therapy in the outpatient setting, eg, antibiotic stability, patient compliance, complications of the initial infection, and superinfection, were well monitored by the authors. Another potential feature of outpatient therapy could be a tendency to delay appropriate changes in therapy or to persist in ineffective therapy because of infrequent observations of the patient. In each of the series published to date,
The Smithsonian Collection of Newspaper Comics
Authors: Lester S. King
Journal: JAMA (1978)

For most adults an anthology of comic strips will arouse two chains of association. One has to do with nostalgia, the other with an awareness of changing cultural patterns. The two may intermingle. The degree of nostalgia will depend on one's age. Those whose memories readily extend back to the second decade of the century will, on seeing this new volume, scan it eagerly for the old favorites—the Katzenjammer Kids, Krazy Kat, Happy Hooligan, Jiggs and Maggie. All these and more are represented by at least a few samples that bring back old memories—in my own case, eg, spreading the newspaper on the floor (that was an important part of the ritual, perhaps because I was too small to hold the paper more properly) and reading the captions while lying prone. Each of us will have different memories and emotional reactions, depending, obviously, on the point in time when the