Sex Chromatin and Chromosome Analysis in the Diagnosis of Sex Abnormalities
Authors: DOROTHY L. WILLIAMS
Journal: Annals of Internal Medicine (1966)

Review1 February 1966Sex Chromatin and Chromosome Analysis in the Diagnosis of Sex AbnormalitiesDOROTHY L. WILLIAMS, M.D., JOHN W. RUNYAN, M.D., F.A.C.P.DOROTHY L. WILLIAMS, M.D.Search for more papers by this author, JOHN W. RUNYAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-2-422 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past several years there has been much improvement and simplification of cytogenetic techniques. This has helped to remove this field from the realm of basic research and investigation to that of increasing practical importance to clinical medicine. It can now be a valuable aid in the understanding, diagnosis, and sometimes the treatment of abnormalities and syndromes previously poorly understood. Cytogenetics attempts to correlate the microscopic structural and numerical abnormalities of chromosomes with the clinical changes and syndromes associated with them.Since population surveys are now available concerning the known frequencies of specific syndromes, these data at once add...References1. MACLEANHARNDEND. COURT-BROWN NGWM: Abnormalities of sex chromosome constitution in newborn babies. Lancet 2: 406, 1961. CrossrefMedlineGoogle Scholar2. POLANI PE: Molecular Genetics And Human Disease. Charles C Thomas, Springfield, Ill., 1960, p. 153. Google Scholar3. CARRLPOOL DHMB: Chromosome studies in abortuses and stillborn infants. The Lancet 2: 603, 1963. CrossrefMedlineGoogle Scholar4. BARRBERTRAM MLEG: A morphological distinction between the neurones of the male and female, and the behavior of the nucleolar satellite during accelerated nucleoprotein synthesis. Nature (London) 163: 676, 1949. CrossrefMedlineGoogle Scholar5. 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Runyan, M.D., University of Tennessee College of Medicine, 951 Court Ave., Memphis, Tenn. 38103. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDie gynäkologische Röntgendiagnostik in der PädiatrieClinical Manifestations of Chromosome DisordersChromosome Karyotype 45,X/46,XY Follow-upDOROTHY L. WILLIAMS, M.D., JOHN W. RUNYAN JR., M.D.Die nosologische Stellung des XO/XY-MosaizismusNeoplasms of dysgenetic gonads 1 February 1966Volume 64, Issue 2Page: 422-459KeywordsChromatinChromosomesCytogeneticsEndocrinologyMedical servicesOligomenorrheaPediatricsResearch grants Issue Published: 1 February 1966 PDF DownloadLoading ...