Gastric Secretion in Chronic Pancreatitis
Authors: ROBERT E. KRAVETZ
Journal: Annals of Internal Medicine (1965)

Article1 November 1965Gastric Secretion in Chronic PancreatitisROBERT E. KRAVETZ, M.D., HOWARD M. SPIRO, M.D., F.A.C.P.ROBERT E. KRAVETZ, M.D.Search for more papers by this author, HOWARD M. SPIRO, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-776 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe isolation of a potent gastrin like gastric secretagogue from the nonbeta cell tumor of the pancreas by Gregory, Tracy, French, and Sircus (1) has provided an explanation for the gastric hypersecretion and multiple peptic ulcerations in patients with the Zollinger-Ellison syndrome. Attention is now turning to the role of the normal pancreas in the control of gastric secretion. It would seem reasonable to conclude that if the tumor contains a gastric secretagogue, the normal pancreas might also contain this hormone although perhaps in smaller amounts. Several groups, however, have consistently failed to find a humoral stimulant of gastric secretion...References1. GREGORYTRACYFRENCHSIRCUS RAHJJMW: Extraction of a gastrin-like substance from a pancreatic tumour in a case of Zollinger-Ellison syndrome. Lancet 1: 1045, 1960. CrossrefMedlineGoogle Scholar2. MCILRATHKENNEDYHALLENBECK DCJAGA: Relationship between atrophy of the pancreas and gastric secretion: an experimental study. Amer. J. Dig. Dis. 8: 623, 1963. CrossrefMedlineGoogle Scholar3. HALLENBECKCODEMCILRATH GACFDC: Absence of demonstrable gastric secretagogue in normal pancreatic tissue. Gastroenterology 44: 627, 1963. CrossrefMedlineGoogle Scholar4. OSBORNEPERNOKASBROWN MPLNM: Studies on the preparation and nature of a gastric secretagogue of pancreatic origin. New Eng. J. Med. 268: 465, 1963. 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CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Haven, ConnecticutFrom the Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn.This study was supported in part by grants AM-04759-05 and A-5156, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Howard M. Spiro, M.D., Yale University School of Medicine, New Haven, Conn. 06411. 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