Tumor-Associated Nephrogenic Diabetes Insipidus
Authors: Joshua Feibusch, Jose L. Barbosa-Saldivar, Robert S. Bernstein, Gary L. Robertson
Journal: Annals of Internal Medicine (1980)

Brief Reports1 June 1980Tumor-Associated Nephrogenic Diabetes InsipidusJOSHUA FEIBUSCH, M.D., JOSE L. BARBOSA-SALDIVAR, M.D., ROBERT S. BERNSTEIN, M.D., GARY L. ROBERTSON, M.D.JOSHUA FEIBUSCH, M.D.Search for more papers by this author, JOSE L. BARBOSA-SALDIVAR, M.D.Search for more papers by this author, ROBERT S. BERNSTEIN, M.D.Search for more papers by this author, GARY L. ROBERTSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-6-797 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDistant effects of benign or malignant tumors, mediated by humoral factors, are well known in the medical literature. Among these, the syndrome of inappropriate antidiuretic hormone secretion is frequently seen in malignant tumors. The opposite situation, that is, nephrogenic diabetes insipidus, or resistance to endogenous antidiuretic hormone, has never been described in association with a tumor. We report here what we believe to be the first such case.A 47-year-old Hispanic man was admitted to St. Luke's Hospital Center in November 1977. The patient was well until January 1974, when he was first hospitalized for resection of an obstructing ileal...References1. MILLER M, DALAKOS T, MOSES A, FELLERMAN H, and STREETEN D. Recognition of partial defects in antidiuretic hormone secretion. Ann Intern Med. 1970;73:721-29. LinkGoogle Scholar2. HICKEY R and HARE K. The renal excretion of chloride and water in diabetes insipidus. J Clin Invest. 1944;23:768-75. CrossrefMedlineGoogle Scholar3. ROBERTSON G, MAHR E, ATHAR S, and SINHA T. Development and clinical application of a new method for the radioimmunoassay of arginine vasopressin in human plasma. J Clin Invest. 1973;52:2340-52. CrossrefMedlineGoogle Scholar4. ROBERTSON G and ATHAR S. The interaction of blood osmolality and blood volume in regulating plasma vasopressin in man. J Clin Endocrinol Metab. 1976;42:613-20. CrossrefMedlineGoogle Scholar5. KAMOI K, HAMA H, ITO S, and MATSUOKA M. Immune complexes in diabetes insipidus syndrome of rabbits immunized with vasopressin. Endocrinol Jpn. 1977;24:239-43. CrossrefMedlineGoogle Scholar6. BRESLOW E and WALTER R. Binding properties of bovine neurophysins I and II: an equilibrium dialysis study. Mol Pharmacol. 1972;8:75-81. MedlineGoogle Scholar7. CHAN W, HRUBY V, FLOURET G, and DU VIGNEAUD V. 4-Leucine-oxytocin: natriuretic, diuretic, and antivasopressin polypeptide. Science. 1968;161:280-1. CrossrefMedlineGoogle Scholar8. DATTA H and CHAUDHURY R. The antidiuretic hormone blocking effect of some oxytocin analogues. J Endocrinol. 1968;42:345-6. CrossrefMedlineGoogle Scholar9. DOUSA T, HECHTER O, WLATER R, and SCHWARTZ I. [8-arginine] -vasopressinoic acid: an inhibitor of rabbit kidney adenyl cyclase. Science. 1979;167:1134-5. CrossrefGoogle Scholar10. ANDERSON P, BERL T, MCDONALD K, and SCHRIER R. Prostaglandins: effects on blood pressure, renal blood flow, sodium and water excretion. Kidney Int. 1976;10:205-15. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOSHUA FEIBUSCH, M.D.; JOSE L. BARBOSA-SALDIVAR, M.D.; ROBERT S. BERNSTEIN, M.D.; GARY L. ROBERTSON, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySevere polyuria and polydipsia as major clinical signs in a horse with unilateral renal adenocarcinomaWater Transport in the Kidney and Nephrogenic Diabetes InsipidusHyperosmolar coma due to lithium-induced diabetes insipidusNephrogenic diabetes insipidus. An unusual presentation of recurrent rectal cancerDiabetes InsipidusVasopressinClinical and Laboratory Features of Central and Nephrogenic Diabetes Insipidus and Primary Polydipsia 1 June 1980Volume 92, Issue 6Page: 797-798KeywordsAntidiuretic hormoneHispanic peopleMalignant tumorsSyndrome of inappropriate antidiuretic hormone secretion ePublished: 1 December 2008 Issue Published: 1 June 1980 PDF downloadLoading ...