tbuckley/cabot-search huggingface dataset:
Adhesive Rubber Dam.
Authors: Fenton B. Turck
Journal: JAMA (1901)

Chicago, May 6, 1901. <h3>To the Editor:</h3> —Dr. J. B. Murphy, inThe Journalfor May 4, presents an article entitled "Adhesive Rubber Dam for the Prevention of Possible Infection at the Site of Operation," in which he recommends a device invented by me, i. e., the rubber dam for protection of the skin around the field of operation. Dr. Murphy states that he has used it with gratifying results at Mercy Hospital. Since "imitation is the sincerest kind of flattery," I am accordingly highly pleased to see commendation of my method emanate from an authority so favorably known to the profession. I was somewhat surprised, however, not to find any mention of my work on this subject. After a careful perusal of Dr. Murphy's paper I therefore could but conclude that the Doctor, though he is undoubtedly a diligent reader of current medical literature, is ignorant of my work.
Predictors of maintained infarct artery patency after primary angioplasty in high risk patients in PAMI-2
Authors: Keith H. Benzuly, William W. O'Neill, Bruce Brodie, John Griffin, Thomas Shimshak, Denise E. Jones, Mariann Graham, Liodmila Mitina, Cindy L. Grines
Journal: Journal of the American College of Cardiology (1996)
General practitioners' access to x ray services
Authors: K D Foord
Journal: BMJ (1991)

11) mm Hg; (p<OOOl), and the median difference was 5 mm Hg (interquartile range 2-8 mm Hg; range 0-15 mm Hg).Muffling was recorded in 78% of the group and blood pressure was not heard to zero in any subject.These findings are similar to those of Perry et al,' though the distribution of differences between phase IV and phase V readings was shifted towards the right in our study (table ).Distribution (%) ofdifferences between diastolic pressures measured at phase I 'and at phase l in those with auidible muffling ofsounds Difference (mm Hg)
<i>LNK</i>Mutations in<i>JAK2</i>Mutation–Negative Erythrocytosis
Authors: Terra L. Lasho, Animesh Pardanani, Ayalew Tefferi
Journal: New England Journal of Medicine (2010)

To the Editor: Erythrocytosis occurring in association with a subnormal serum erythropoietin level is indicative of underlying erythropoietin-independent erythropoiesis, in patients with polycythem...
Foley Catheter in Removal of a Foreign Body From Rectum
Authors: Krishna K. Vadlamudi
Journal: JAMA (1972)

<h3>To the Editor.—</h3> Foreign bodies in the rectum are of such variety that no single procedure for their removal can be mandated.<sup>1</sup>Each case represents a special problem in its management. It must be remembered that careless removal is more likely to result in injury than that which resulted from its insertion. Recently, we have extracted a light bulb from the rectum using insertion of two Foley catheters and its success has prompted us to report this technique. <h3>Report of a Case.—</h3> A 50-year-old man was seen in the emergency room of French and Polyclinic Medical School and Health Center on July 30,1971, with discomfort in the rectum following insertion of a light bulb a few hours before. Rectal examination revealed a light bulb three inches above the anal verge with the screw end of the bulb projecting towards the examiner. The metallic screw part of the bulb was
Regeneration of full-thickness abdominal wall defects in rats using collagen scaffolds loaded with collagen-binding basic fibroblast growth factor
Authors: Chunying Shi, Wei Chen, Yannan Zhao, Bing Chen, Zhifeng Xiao, Zhenliang Wei, Xianglin Hou, Jinglong Tang, Zhaoxu Wang, Jianwu Dai
Journal: Biomaterials (2010)
Anaesthetic Staffing and Training Requirements in Scotland
Authors: G. D. Parbrook
Journal: BMJ (1971)

In Scotland there is an average of 12 consultant vacancies and 14 Fellows qualifying per year, but these are insufficient to meet all the vacancies as several emigrate or return abroad. The existing registrar and senior registrar establishments are inadequate to meet the numbers of consultants required if full allowance is made for special factors, such as the high proportion of women graduates and the rising proportion of overseas trainees.A backlog of understaffing in Scotland relative to England and Wales is shown by comparison of the ratio of anaesthetists to surgeons. The existing rate of expansion of 6% per year must continue for many years or be increased if staffing levels are to come into line with those elsewhere in Britain.
CORRELATION OF THE HISTOLOGICAL AND CHEMICAL CHANGES IN THE SPLEEN DURING NECROSIS AND AUTOLYSIS
Authors: Harry J. Corper
Journal: The Journal of Experimental Medicine (1912)

The most marked chemical changes in a disintegrating spleen are noticed during the period when karyorrhexis and karyolysis are the characteristic features. When pyknosis alone is prominent almost all of the several constituents are in the coagulable or precipitable fraction, just as they are in the original normal tissue. After karyolysis is practically complete the coagulable and precipitable elements of the tissue still gradually decrease in amount, but the rate is far below that occurring during karyorrhexis and karyolysis. Moreover, even when microscopical nuclear disintegration is practically at an end, the chemical process of disintegration is still going on, but very slowly. Finally, when nuclear structures can no longer be seen in the spleen, about 72 per cent. of the nuclein nitrogen, about 50 per cent. of the original insoluble phosphorus, and 70 per cent. of the original insoluble nitrogen, are still in the insoluble form (precipitable and coagulable by alcohol), while about two thirds of the phosphatid phosphorus remains in complex organic combinations.
Interferon beta in multiple sclerosis
Authors: R. G Richards
Journal: BMJ (1996)

Interferon beta in multiple sclerosisClinical cost effectiveness fals at thefirst hurdle Interferon beta-lb has now been granted a product licence in Britain.The department of health recently issued an executive letter providing "guidance" on the introduction of interferon beta:' purchasing authorities were asked "to initiate and continue prescribing of Beta-Interferon through hospitals."This is the first time that the NHS Executive has issued such a directive.Data from the Multiple Sclerosis Study Group show that interferon beta-lb significantly reduces the number of demyelinated plaques on magnetic resonance imaging in patients with multiple sclerosis and reduces relapse rates by up to 30%.2However, the studies showed no evidence of any reduction in the more clinically relevant endpoint-the progression of disability, which should be the goal of treatment.Patients treated with 8 MIU of interferon beta-lb avoided one in three relapses by the end of the second year and an average of 1.5 relapses over five years.4At a minimum cost of £10 000 per year, this -equates to £33 000 per relapse avoided.An average patient might experience 25-30 relapses in the course of his or her lifetime, so achieving a theoretical relapse free patient would cost up to i1m.In reality the drug will probably only delay rather than prevent disability, and it is therefore unlikely that economic benefits will include avoiding the need for social care for these patients.Most requests to health authorities for healthcare developments offer a far better health gain return.
No Evidence of Efficacy or Evidence of No Efficacy
Authors: Marco A. Arruda
Journal: JAMA Pediatrics (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
The Future of Internal Medicine: Framing the Questions
Authors: Samuel O. Thier
Journal: Annals of Internal Medicine (1991)

Editorials1 January 1991The Future of Internal Medicine: Framing the QuestionsSamuel O. Thier, MDSamuel O. Thier, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-1-88_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDiscomfort, anxiety, and a sense of isolation are all too common emotions in the internal medicine community today, as the discipline appears progressively less attractive to students, residents, and practitioners. The first two emotions are effective goads to action, but a sense of isolation is dangerous, letting us believe the pressures on us are unique. Perspective is essential if we are to frame our problems properly and have any chance of solving them. Changes in internal medicine could be made within the narrow confines of internal medicine's own needs and perspectives or such change could be approached within the broader... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Institute of Medicine National Academy of Sciences Washington, DC 20418 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReflections on residency training: 1991The State of Internal MedicineGregg Coodley, MD, Marcia Kerensky Coodley, MD 1 January 1991Volume 114, Issue 1Page: 88-89KeywordsAnxietyEmotionsForecasting Issue Published: 1 January 1991 PDF downloadLoading ...
ACRODYNIA IN ADULTS
Authors: CLEVELAND J. WHITE
Journal: JAMA (1926)

The Journalhas twice called the attention of the American medical public, editorially, 1 to the continued presence of acrodynia in the United States and the desirability of publicity in connection with it. This is all the more to the point because it is not asking too much in the way of diagnosis, for the cutaneous phase of the syndrome is so distinctive—almost pathognomonic—that it is calculated to lead the practitioner at once to the correct diagnosis. Thus, the first set of symptoms is the general, consisting of the gastro-intestinal and neurologic, and the second, the cutaneous. To repeat, the latter are so distinctive that they are calculated at once easily to remove the condition clinically from a large, more or less indiscriminate group of possible avitaminoneurologic states, even though it may be given to one rarely to see a case. The red, painful palms and soles of the raw-beef
BIGpre: A Quality Assessment Package for Next-Generation Sequencing Data
Authors: Tongwu Zhang, Yingfeng Luo, Kan Liu, Linlin Pan, Bing Zhang, Jun Yu, Songnian Hu
Journal: Genomics Proteomics & Bioinformatics (2011)

Abstract The emergence of next-generation sequencing (NGS) technologies has significantly improved sequencing throughput and reduced costs. However, the short read length, duplicate reads and massive volume of data make the data processing much more difficult and complicated than the first-generation sequencing technology. Although there are some software packages developed to assess the data quality, those packages either are not easily available to users or require bioinformatics skills and computer resources. Moreover, almost all the quality assessment software currently available didn’t taken into account the sequencing errors when dealing with the duplicate assessment in NGS data. Here, we present a new user-friendly quality assessment software package called BIGpre, which works for both Illumina and 454 platforms. BIGpre contains all the functions of other quality assessment software, such as the correlation between forward and reverse reads, read GC-content distribution, and base Ns quality. More importantly, BIGpre incorporates associated programs to detect and remove duplicate reads after taking sequencing errors into account and trimming low quality reads from raw data as well. BIGpre is primarily written in Perl and integrates graphical capability from the statistics package R. This package produces both tabular and graphical summaries of data quality for sequencing datasets from Illumina and 454 platforms. Processing hundreds of millions reads within minutes, this package provides immediate diagnostic information for user to manipulate sequencing data for downstream analyses. BIGpre is freely available at http://bigpre.sourceforge.net/.
Surgery for Massive Myocardial Infarction
Authors: RAYMOND O. HEIMBECKER, GUY LEMIRE, CHARLES CHEN
Journal: Circulation (1968)

Emergency myocardial infarctectomy has been studied experimentally and clinically. The clinical experience describes encouraging results in two of four consecutive patients. The criteria of patient selection are described, along with a suggestion that associated perforation of the ventricular septum, as documented in three of the patients, makes the operative procedure more difficult and the results less satisfactory. Experimental myocardial infarction was studied in two groups of calves with a mortality rate of 100%. In the first group emergency resuscitation by massage and bypass produced an initial resuscitation rate of 14% but a survival rate of only 11%. In the second control group of fatal infarction, resuscitation was attempted by 45 minutes of bypass, with improvement in the resuscitation rate to only 23% and proportionate improvement in the survival rate to 18%. Emergency infarctectomy dramatically increased the initial salvage rate to 100% and improved the survival rate to 41%.
PWE-152 Palliative biliary stenting; not so palliative in many cases!!
Authors: V Vemala, P Premchand
Journal: Gut (2012)

<h3>Introduction</h3> Palliative biliary stenting has been practiced widely to treat symptomatic patients with non-resectable pancreatic carcinoma and other forms of cancers obstructing the biliary system. We have undertaken this study to assess the outcome of this practice in these patients especially who are on end of life care and to assess whether biliary interventions on occasions cause or hasten death. <h3>Methods</h3> We retrospectively studied 160 consecutive patients who had ERCP (Endoscopic Retrograde CholangioPancreatography) from October 2010 to October 2011 at Clinical Diagnostic Unit, Queen9s Hospital, Romford, London. Data were collected using Scorpio data (GI reporting tool) on demographic variables, aetiology, type of cancer, Patients symptomatology pre and post procedure, Liver function tests (Cyberlab), complications secondary to ERCP, 30-day mortality post ERCP. <h3>Results</h3> Of the 160 ERCP patients, 12 (7.5%) had 30-day mortality post ERCP. One patient could not be stented due to technical reasons. Of the 12 patients 11 had Metastatic Ca that is, Pancreas (5), Breast (2), Oesophagus (1), Cholangiocarcinoma (1), Lung (1), unknown primary (1). Of the cancer patients 6 (11) were male and 5 (11) were female with a mean age of 70.7 years. Seven of those patients had a presenting complaint of severe abdominal pain not fully controlled with opiates, all 11 (11) patients had varying degree of deranged liver function tests predominantly cholestatic picture, 3 (11) patients had SIRS (Systemic Inflammatory Response Syndrome). Technical failure to place the stent occurred in 1patient. Post ERCP 6 (11) were symptomatically better on discharge, 4 (11) had worsening of their symptoms, Baseline bilirubin was 213 μmol/l with 7 days post ERCP bloods showed improvement with mean bilirubin of 73 μmol/l in four patients (11), ALP of 6 (11) and conversely rest of the patients showed worsening LFT9s. 30 days mortality showed four patients died in hospital, two in hospice and five at home. All three patients with SIRS died within 1-week post ERCP. <h3>Conclusion</h3> Malignant biliary obstruction has significant mortality. Identification of patients with SIRS is important as these patients have very high mortality and may not improve from ERCP and biliary interventions. Older age &gt;65 years and more advanced disease were related with higher mortality despite interventions. This series suggest better selection of patients for biliary interventions in advanced metastatic cancers. <h3>Competing interests</h3> None declared.
USEFULNESS OF AORTIC VALVE CALCIFICATION MEASURED BY COMPUTED TOMOGRAPHY TO PREDICT HEMODYNAMIC PROGRESSION OF AORTIC STENOSIS
Authors: Marie-Annick Clavel, Philippe Pibarot, David Messika-Zeitoun, Romain Capoulade, Joseph Malouf, Philip Araoz, Lionel Tastet, Hector Michelena, Eric Larose, Caroline Cueff, Jordan D. Miller, Alec Vahanian, Maurice Sarano
Journal: Journal of the American College of Cardiology (2014)
Cocaine Use in Pregnancy: Physicians Urged to Look for Problem Where They Least Expect It
Authors: Andrew Skolnick
Journal: JAMA (1990)

THE PROBLEM of cocaine use during pregnancy is being ignored by too many physicians who think that drug abuse by pregnant women is a problem of minorities, urban populations, and lower-socioeconomic groups. So says Ira J. Chasnoff, MD, associate professor of pediatrics and psychiatry at Northwestern University Medical School, Chicago, Ill. This presumption is not only wrong, but it may prevent physicians from identifying patients in need of help, he says. Speaking at the 38th annual meeting of the American College of Obstetricians and Gynecologists (ACOG), in San Francisco, Chasnoff reported a study that suggests physicians with the "NIMO [Not In My Office] syndrome" are sadly mistaken. "The use of illicit drugs is common among pregnant women regardless of their race or socioeconomic status," he says. In their study (<i>N Engl J Med</i>. 1990;322:1202-1206), Chasnoff and colleagues find little difference in the prevalence of substance use among women who received
Reviews and Notes: Environmental and Occupational Medicine
Authors: Linda M. Frazier
Journal: Annals of Internal Medicine (1993)

Literature of Medicine15 September 1993Reviews and Notes: Environmental and Occupational MedicineLinda M. Frazier, MD and Gary N. Greenberg, MDLinda M. Frazier, MDDivision of Occupational and Environmental Medicine, Duke University, Durham, NC 27701.Search for more papers by this author and Gary N. Greenberg, MDDivision of Occupational and Environmental Medicine, Duke University, Durham, NC 27701.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-6-199309150-00050 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Environmental and Occupational MedicineSecond edition. William N. Rom; ed. 1493 pages. Boston: Little, Brown; 1992. $185.00.Each year, 7 to 8 of every 100 U.S. workers suffer a work-related injury or illness; 70 000 of these result in permanent impairment. Ten textbooks addressing occupational medicine have been written or published in revised editions in the last 5 years. The new edition of Rom's textbook, which was already one of the major references in the field, has been strengthened by the addition of new material.The first section of the book reviews epidemiology, the scientific basis for identifying potential carcinogens, ... Author, Article, and Disclosure InformationAffiliations: Division of Occupational and Environmental Medicine, Duke University, Durham, NC 27701. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1993Volume 119, Issue 6Page: 544KeywordsHealth careHealth information technologyMultidrug resistant tuberculosisMusculoskeletal injuryPathogensPrevention, policy, and public healthRespiratorsSystemic diseasesToxicologyTraumatic injury ePublished: 15 August 2000 Issue Published: 15 September 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Spain could be 25 000 specialists short by 2025
Authors: M. d. Lago
Journal: BMJ (2009)

Spain currently lacks around 3200 specialist doctors, and if present conditions continue the shortage will rise to 9000 by 2015 and could be 25 000 by 2025, says a report from the Spanish Ministry of Health and Consumer Affairs.

The specialties of paediatrics and family and community medicine have the severest shortages, with up to 35% more specialists needed. More doctors are also needed in thoracic surgery, geriatrics, paediatric surgery, neurosurgery, and clinical pharmacology.

For the report Las Palmas University looked at census data on professionals in work; and experts from regional authorities and the ministry estimated the number of specialists needed. Computer modelling then …
The treatment of epithelial ovarian cancer
Authors: F. Qazi, W. P. McGuire
Journal: CA A Cancer Journal for Clinicians (1995)

The treatment and long-term survival of patients with ovarian cancer varies by stage. At present, five-year survival for patients with early-stage disease ranges from 50 to 95 percent, while five-year survival for patients with advanced-stage disease is less than 25 percent. Several new drugs with significant activity in advanced-stage ovarian cancer offer hope for increased long-term survival in the future. This article reviews the current and experimental approaches to the treatment of all stages of ovarian cancer.
Angiotensin-induced hypertension in conscious dogs: biochemical parameters and baroreceptor reflex
Authors: A BECK, B GRASMUGG, E SINGER, S BACHER, G RABERGER
Journal: Cardiovascular Research (1985)

The effects of a continuous iv infusion (osmotic minipumps) of angiotensin II (80 ng . kg-1 . min-1) and isoprenaline (10 ng . kg-1 . min-1) lasting 28 days were studied in six normotensive, conscious dogs. The parameters measured were systolic and diastolic blood pressure, heart rate, levels of angiotensin II, renin activity, aldosterone and antidiuretic hormone in plasma, baroreceptor reflex sensitivity and body weight. The treatment resulted in an approximately sevenfold increase in plasma angiotensin II level from 62.9 +/- 24.5 pg . ml-1 to 455.3 +/- 95.6 pg . ml-1. Systolic and diastolic blood pressure, measured for the first time 2 days after implanting the minipumps, were markedly increased throughout the infusion period (pretreatment value: 123.8 +/- 5.3/68.3 +/- 3.8 mmHg; after 2 days: 159.8 +/- 12.0/100.5 +/- 9.8 mmHg; after 28 days: 159.8 +/- 7.1/98.3 +/- 6.4 mmHg, whereas the heart rate remained unchanged due to the combined effects of angiotensin II and the concomitantly given isoprenaline. A high correlation was found between angiotensin II level in plasma and mean arterial blood pressure (r = 0.846; p less than 0.001). Furthermore, plasma renin activity was markedly suppressed by the treatment, and aldosterone levels rose. Plasma antidiuretic hormone levels were found to be unchanged at the chosen sampling time. A decrease in baroreceptor reflex sensitivity accompanied the development of the hypertensive state. There was also a loss of body weight during the infusion of angiotensin II and isoprenaline. The data provide evidence for the usefulness of the presented experimental protocol as an alternative model of arterial hypertension in chronically instrumented, conscious dogs.