tbuckley/cabot-search huggingface dataset:
Recent trends in admissions and mortality due to peptic ulcer in England: increasing frequency of haemorrhage among older subjects
Authors: J Higham
Journal: Gut (2002)

Although overall admission rates for peptic ulcer in England declined from the 1950s up until the mid 1980s, perforations among older women increased, possibly due to increasing use of non-steroidal anti-inflammatory drugs (NSAID). Since then, proton pump inhibitors, antibiotic treatment for Helicobacter pylori, low dose aspirin, and selective serotonin reuptake inhibitors (SSRI) have been introduced Aims: To determine time trends for hospital admissions for peptic ulcer from 1989 to 1999 (England), mortality from 1958 to 1998 (England and Wales), and prescriptions for ulcer healing drugs, aspirin, NSAID, oral anticoagulants, and SSRI from 1990 to 1999 (England).Hospital episode statistics for admissions and mortality were obtained from the Office of National Statistics: community prescription data from Statistics Division 1E of the Department of Health.Between 1989/90 and 1998/99, there was a marked rise in admissions for haemorrhage in older patients, particularly from duodenal ulcer. Perforations from gastric ulcer declined but perforations from duodenal ulcer increased among men at older ages. Since the mid 1980s mortality has declined in all age groups except for older women with duodenal ulcer. The number of prescriptions for histamine H(2) receptor antagonists remained constant but those for proton pump inhibitors increased by 5000%, aspirin 75mg by 460%, oral anticoagulants by 200%, and NSAID by 13% between 1990 and 1999. Since the introduction of SSRI in 1991, prescriptions have increased 15-fold.Admission rates for gastric and duodenal ulcer haemorrhage and duodenal ulcer, but not gastric ulcer perforation, increased among older subjects, over a time when prescriptions for proton pump inhibitors, low dose aspirin, oral anticoagulants, and SSRI increased.
Swiss parliament may try to ban "suicide tourism"
Authors: C. Dyer
Journal: BMJ (2003)

The Swiss authorities are considering a ban on “suicide tourism,” after a Briton with advanced motor neurone disease ended his life in Zurich with the help of the assisted suicide group Dignitas.

Reginald Crew, 74, a former car worker from Merseyside, flew to the city with his wife and daughter on 20 January and died after taking a drink laced with a lethal dose of barbiturates. The number of foreigners travelling to Zurich to kill themselves grew from just three in 2000 to 55 last year. But a bill …
Phase II, Double-Blinded, Randomized Study of Enzastaurin Plus Pemetrexed as Second-Line Therapy in Patients with Advanced Non-small Cell Lung Cancer
Authors: Alberto Chiappori, Gerold Bepler, Fabrice Barlesi, Jean-Charles Soria, Martin Reck, Alessandra Bearz, Fernando Barata, Giorgio Scagliotti, Keunchil Park, Asavari Wagle, Astra M. Liepa, Yan Daniel Zhao, Nadia Chouaki, Neill Iscoe, Joachim von Pawel
Journal: Journal of Thoracic Oncology (2010)
Stress concentrations induced by flow
Authors: S. RODBARD, M. FARBSTEIN
Journal: Cardiovascular Research (1972)

Flow through gelatin-agar tubes produced birefringence at local concentrations of mechanical stresses. The number of fringes varied with stream velocity. Stresses were maximal at valve roots, the downstream ends of stenoses, and on the inner walls of the test channels. The method facilitates the study of wall stress.
Reviews and Notes: Primary Care of Women
Authors: Kay A. Bauman
Journal: Annals of Internal Medicine (1996)

Literature of Medicine15 March 1996Reviews and Notes: Primary Care of WomenKay A. Bauman, MD, MPHKay A. Bauman, MD, MPHUniversity of Hawaii; Mililani, HI 96789Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-6-199603150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail DP Lempke, J Pattison, LA Marshall, and DS Cawley; eds. 584 pages. Norwalk, CT: Appleton & Lange; 1995. $34.95. ISBN 0-8385-9813-7. Order phone 800-423-1359.This is one of a few recently published books that have been intended to serve primary care physicians as resources for women's health care. How useful is such a text? Is it more or less comprehensive than a traditional internal medicine text? Is it worth my investment?Careful comparison with an internal medicine text showed that for diseases specific to or more common in women, Primary Care of Women is more comprehensive and has a more ... Author, Article, and Disclosure InformationAffiliations: University of Hawaii; Mililani, HI 96789 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1996Volume 124, Issue 6Page: 617KeywordsHormonesLiver diseasesMigraineObstetrics and gynecologyPregnancyPrimary care physiciansSexual dysfunctionSports and exercise medicineTraditional medicineTreatment guidelines ePublished: 15 August 2000 Issue Published: 15 March 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Asthma and the Inhaler
Authors: C. Francis
Journal: BMJ (1948)

MEDCAL JOUNAAnother point is that I have followed up a number of patients who have suffered from non-pulmonary tuberculosis and who later married, and have found that pregnancies were unusual among them.This difference between patients with phthisis and patients with other forms of tuberculosis offers an interest- ing commentary on the pathogenesis of the disease.-Iam, etc.,
INCIDENCE, PREDICTIVE FACTORS AND PROGNOSTIC VALUE OF MYOCARDIAL INJURY FOLLOWING SUCCESSFUL UNCOMPLICATED TRANSCATHETER AORTIC VALVE IMPLANTATION BY TRANSFEMORAL AND TRANSAPICAL APPROACHES
Authors: Josep Rodes-Cabau, Marcos Gutierrez, Rodrigo Bagur, Robert Delarochelliere, Daniel Doyle, Melanie Cote, Jacques Villeneuve, Olivier F. Bertrand, Juan Manazzoni, Philippe Pibarot, Eric Dumont
Journal: Journal of the American College of Cardiology (2011)
Angiotensin II regulates 11β-hydroxysteroid dehydrogenase type 2 via AT2 receptors
Authors: Bettina Lanz, Bert Kadereit, Samuel Ernst, Kushiar Shojaati, Maja Causevic, Brigitte M. Frey, Felix J. Frey, Markus G. Mohaupt
Journal: Kidney International (2003)
Catatonic stupor in elderly woman with hyperparathyroidism.
Authors: T. D. Hockaday, W. M. Keynes, J. K. McKenzie
Journal: BMJ (1966)

Epidemic Bronchiolitis-Field et al.MEDIJHRNAL 85increases with the age of the child, and that it is poor under 4 months of age (Chanock et al., 1961).As already noted, six out of eight children in this trial who had no serological response to respiratory syncytial virus antigen were 12 weeks old or less.Other viruses have also been implicated in respiratory disorders of infants (Clarke, Corner, Gambier, Macrae, and Peacock, 1964 ; Gardner et al., 1964 ; Holzel et al., 1965), but the fact that 10 out of 18 cases showed a fourfold rise in titre to respiratory syncytial virus, and that all cases had very similar symptoms and occurred in an epidemic, would strongly suggest that most cases were due to infection with respiratory syncytial virus.It is evident that ampicillin did not influence recovery of children with bronchiolitis in this trial.Patients with this disorder are often treated with antibiotics in the belief that these will at least prevent secondary infection (Heycock and Noble, 1962).The only evidence for this in the present series was in one case of otitis media.The duration of symptoms and signs was very similar to that found in previous cases treated by us with other wide-spectrum antibiotics, suggesting that had they been used in the trial instead of ampicillin the results would have been the same.It is rare in domiciliary practice and uncommon in hospital to find infants with bronchiolitis who are not being treated with antibiotics.The results of this trial would suggest that their use does not hasten recovery.Apart from the question of cost the use of unnecessary antibiotics may not only cause iatrogenic illness but may increase the number of drug-resistant organisms.It is suggested that, in epidemic bronchiolitis of infants, antibiotics are used more to treat the physician's peace of m-nd than the patient's disease. SummaryA double-blind study of the effect of ampicillin in an outbreak of bronchiolitis was carried out on 52 patients.Eight were removed from the trial because of complications.In the 25 treated with ampicillin and the 19 given a placebo there was no significant difference in the duration of symptoms and signs.Respiratory syncytial virus was shown to be the cause of infection in 10 out of 18 patients investigated.There were no deaths in the trial.
Abstract 2297: ERβ agonists reduce letrozole resistant breast cancer cell growth and diminish aromatase expression and activity
Authors: Manonmani Ganapathy, Hareesh Babu Nair, Nameer B. Kirma, Naveen Kumar Krishnegowda, Ratna Kumar Vadlamudi, Kusuma Kurmayagari, Mary Tagliaferri, Isaac Cohen, Rajeshwar Rao Tekmal
Journal: Cancer Research (2011)

Abstract Aromatase inhibitors (AI) have shown efficacy against estrogen receptor (ER) positive breast cancer; however, development of resistance to AI is a major concern. The need to develop therapeutic agents that overcome AI resistance is urgent. We investigated whether synthetic and natural selective ERβ agonists restored sensitivity to AI and anti-estrogens in hormone resistant breast cancer cells. Our data suggest that ERβ agonists such as DPN (a synthetic compound) and plant derived Nyasol, Liquiritigenin, and MF101 (Menerba) ERβ agonists may restore sensitivity against resistance by the current drugs. Natural ERβ agonists in combination with AI reduced cell proliferation in MCF7/ARO (overexpressing aromatase), MCF7/HER2 (overexpressing Her2/neu) LTLT-Ca (letrozole resistant), MCF7/TAM (tamoxifen resistant), SKBR3, and T47D breast cancer cells by 70 % to 90% when compared with DPN/AI combination. Our Western blot and RT-PCR analyses showed that combination treatment with natural ERβ agonist in combination with AI resulted in decreased levels of ERα, Cyclin D1, TNF-α, IL-6 and increased ERβ levels in LTLT-Ca and MCF7/ARO cells. In addition, aromatase expression and activity were decreased due to ERβ agonists/AI combination treatment. The activity of aromatase promoter 1.3, which is activated in breast cancer, was found to be down regulated with Nyasol, Liquiritigenin and MF101 combinations with AI when compared to single compounds in various breast cancer cells. Decreased promoter 1.3 activity is consistent with the combination-treatment decrease in the expression of inflammatory cytokines known to induce this promoter (e.g., IL-6). Our data suggest that inhibition of aromatase expression/activity by natural ERβ agonists (in combination with AI) may be a factor in overcoming AI-resistant breast cancer cell growth by these drugs. Our data also suggest that modulation of inflammatory cytokines may be factors by which ERβ agonists may influence aromatase expression and sensitizing AI-resistant breast cancer to AI therapy. Further work is required to understand the mechanistic aspects of this regulation and to advance natural ERβ agonists to the clinical treatment of AI-resistant breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2297. doi:10.1158/1538-7445.AM2011-2297
Medicine and Society
Authors: Lester S. King
Journal: JAMA (1971)

The health of a people is far too important to rest solely in the hands of doctors: the state must also play a part. Physicians themselves realized this long ago and repeatedly called upon the state to enact laws that would improve health care. As early as the 15th century British physicians sought the help of their king, and in 1511 King Henry VIII propounded decrees to regulate medical services. In the existing state of affairs, declared good King Hal, many incompetent people were practicing medicine, and this resulted in "the grievous hurt, damage, and destruction of many of the King's Liege people." The king consequently set up a form of licensure requirement to ensure the competence of practitioners; and later he chartered the College of Physicians, whose members alone could have the privilege of practicing in the city of London and its environs. The licensing of professional activity protected
False Positive Dipstick Test for Malaria
Authors: Hermann Laferi, Karoline Kandel, Hannes Pichler
Journal: New England Journal of Medicine (1997)

To the Editor: The ParaSight F antigen-capture assay (dipstick test) (Becton Dickinson Microbiology Systems, Sparks, Md.) is a new diagnostic test for Plasmodium falciparum malaria based on the det...
AN IMPROVED APPLICATION OF THE USE OF RENAL FLUOROSCOPY AT THE OPERATING TABLE
Authors: B. H. Hager
Journal: JAMA (1925)

The application of fluoroscopy at the operating table is now conceded to be an essential prerequisite to successful surgery for renal lithiasis. Braasch, in 1919, was the first to stress this principle, which has since been modified by various surgeons to meet their particular needs. By preference, some continue to use the roentgen-ray film rather than the fluoroscope. Without considering the virtues and advantages of either method, the suggestion presented here offers an advantage over fluoroscopy, which entails the presence of a radiologist. The roentgen-ray apparatus in use is a modern bedside unit with a 10 ma. Coolidge radiator tube, using a 5 ma. current. The accompanying illustrations show the principles of its application. As soon as renal exposure has been obtained, a nurse slips the Patterson head operating fluoroscope over the surgeon's head, a sterile cover having been slipped over the nose of the fluoroscope. The time required for
Phase I study of the anti insulin-like growth factor 1 receptor (IGF-1R) monoclonal antibody, AVE1642, as single agent and in combination with bortezomib in patients with relapsed multiple myeloma
Authors: P Moreau, F Cavallo, X Leleu, C Hulin, M Amiot, G Descamps, T Facon, M Boccadoro, D Mignard, J L Harousseau
Journal: Leukemia (2011)
Outcomes of Surgery in Patients 90 Years of Age and Older
Authors: Michael P. Hosking
Journal: JAMA (1989)

During the 11-year period 1975 through 1985, seven hundred ninety-five patients 90 years of age and older underwent operative procedures at the Mayo Clinic, Rochester, Minn. Overall serious morbidity within 48 hours after surgery was 9.4%, and the mortality was 1.6%. The 30-day, 1-year, and 5-year mortality rates were 8.4%, 31.4%, and 78.8%, respectively. Short-term morbidity and both short- and long-term mortality were highly associated with the American Society of Anesthesiologists physical status classification of the patient. Emergency procedures carried a significantly higher risk for morbidity and mortality within the 48-hour period and, to a lesser extent, for long-term mortality. Overall, poorer patient survival was associated with higher American Society of Anesthesiologists class; male sex; preoperative renal, liver, and central nervous system impairment; and surgery on the mouth, nose, or pharynx. When compared with age-, sex-, and calendar Year-matched peers from the general population, there was a modest decrease in patient survival at 1 year that reversed by 2 years, with observed survival at 5 years comparable to the rate expected. (<i>JAMA</i>. 1989;261:1909-1915)
Physicians in the Public Life of France.
Authors: Charles A. L. Reed
Journal: JAMA (1904)

PROFESSOR POZZI—COMBES A PHYSICIAN—COMPOSITION OF THE FRENCH SENATE—THE CHAMBER OF DEPUTIES—PHYSICIANS IN MINOR CIVIL OFFICES—SCIENTIFIC RECORDS, PROFESSIONAL AND PERSONAL STANDING OF PHYSICIANS IN PUBLIC LIFE—SOME NEGLECTED BUT PRESSING DUTIES OF AMERICAN PHYSICIANS. Paris, Aug. 27, 1904. <h3>To the Members of the Medical Profession:</h3> —The active participation of the medical profession in public affairs in France is in striking contrast with the aloofness of American physicians from executive and legislative offices. This was brought to my attention by Professor Pozzi, with whom it was my good fortune to cross the ocean on his return from the meeting of the American Surgical Association at St. Louis. He himself is an example of the highest type of the medical man, using the term in its broad generic sense. A successful practitioner, the author of an accepted text-book of gynecology which has been translated into all the European languages, a literateur and
Objet intermédiaire et relation thérapeutique
Authors: P. Bour
Journal: Psychotherapy and Psychosomatics (1978)

Case Reports| February 16 2010 Objet intermédiaire et relation thérapeutique Subject Area: Psychiatry and Psychology P. Bour P. Bour Centre psychothérapeutique de la Chartreuse, Dijon Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1978) 29 (1-4): 263–266. https://doi.org/10.1159/000287138 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation P. Bour; Objet intermédiaire et relation thérapeutique. Psychother Psychosom 31 December 1978; 29 (1-4): 263–266. https://doi.org/10.1159/000287138 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1978Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Hypoglycemia as a Cause of Seizures
Authors: C. F. Gastineau
Journal: JAMA (1969)

To the Editor:—  In the QUESTIONS AND ANSWERS section ( 208 :159, 1969), the advice is given that a five-hour glucose tolerance test should be done in order to rule out the possibility of hypoglycemia producing grand mal seizures.  A contrary opinion is that hypoglycemia may occur as a result of a number of factors, including the administration of insulin, the use of the sulfonylurea drugs, and several varieties of neoplasms. There is also, commonly, an appreciable fall of the blood sugar to levels below the fasting about three-to-four hours after a loading dose of glucose, or a meal. This latter form of hypoglycemia, in an otherwise healthy person, would not be expected to be severe enough to produce a grand mal seizure. A five-hour glucose tolerance test is an appropriate means for identifying this reactive hypoglycemia, but is a relatively poor means of detecting and proving the other forms of
The world cancer burden.
Authors: P R Burch
Journal: BMJ (1985)

Dominant understandings of genre-as-form have limited our abilities to perceive health awareness: we recognise, and expect, health awareness campaigns from governmental and non-profit agencies. Inversely, we often fail to recognise, or name, health awareness as such when it comes from other sources, such as commercial marketing or advertisements for products. However, rhetorical genre theory centres attention on action brought about by form and, as such, rhetorical genre provides tools for recognising instances of health awareness often escape our notice. One such example is critical-illness insurance marketing. In this article, I argue that critical-illness insurance marketing draws on the same appeals found in cancer awareness campaigns. Through a comparative analysis, I show that Colorectal Cancer Canada and critical-illness insurance marketing represent unpreparedness, rather than cancer, as the exigence, or the problem to be overcome through public discourse, and as such, share a genre of what I call ‘health awareness as preparedness’.
Sunset on the Turnpike
Authors: George N. Braman
Journal: Annals of Internal Medicine (1997)

Ad Libitum1 September 1997Sunset on the TurnpikeGeorge N. Braman, MDGeorge N. Braman, MDBronx, NY 10471Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-5-199709010-00005 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “A singularity is a mathematical point at which space and time are infinitely distorted, where matter is infinitely dense …”The New York Times, 12 February 1997Sunset on the TurnpikeBlack holes and naked singularityKeep me in constant awe of outer space-I haven't felt the force of gravityCollapse my inner sense of time or place.Perhaps my limited trajectoryProtects me from the rims of galaxiesOr this confining earthbound entropyDefies extremes of griefs or ecstasies.Sunset on the Turnpike describes my state-Not truly glacial, but perhaps devoidOf cosmic movement, blending slow and ... Author, Article, and Disclosure InformationAffiliations: Bronx, NY 10471Corresponding Author: George N. Braman, MD, 6142 Delafield Avenue, Bronx, NY 10471. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1997Volume 127, Issue 5Page: 371 ePublished: 15 August 2000 Issue Published: 1 September 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Points: Malnutrition in the Third World
Authors: P. C W Lyn
Journal: BMJ (1985)

Dr M C Petch should perhaps have called his review "Lack of lessons from ambulatory electro- cardiography" (7 September, p 617).This is especially true in the case of ventricular ectopic activity.It is worth repeating what Sir Thomas Lewis had to say: "When extrasystoles are found, the heart among other organs should be scrutinised closely.If no further signs are detected, the extrasystole can be neglected; if other signs are found, the prognosis will be based on these; the extrasystole has served its purpose and can again suffer neglect."'Even with respect to so called "warning arrhythmias," my colleagues and I have shown these months to years before they "progressed" to ventricular fibrillation or bradyarrhythmic death on repeat Holter monitoring.2I would like to differ from Dr Petch on only one specific point: that bradycardia proceeding to asystole suggests a non-cardiac cause.In most cases documented so far the underlying disease was still cardiac,3 although not necessarily coronary.4