tbuckley/cabot-search huggingface dataset:
A Painful Lesson
Authors: Ranjana Srivastava
Journal: Annals of Internal Medicine (2007)

On Being a Patient20 March 2007A Painful LessonRanjana Srivastava, MBBSRanjana Srivastava, MBBSFrom Monash Medical Centre, Melbourne, Victoria 3165, Australia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-6-200703200-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Vivid dreams tumble through my head in no meaningful sequence. In a half-stupefied state I become aware of the stertorous breathing of the woman in the room next door. Rather than being filtered by the walls, her snores are magnified to a swelling roar that engulfs my small space. I wonder how anyone can sleep here. The next minute, I am wide awake with a stab of pain. I turn gingerly in bed, wincing at the effort. Over the next few minutes the pain escalates in intensity and seems everywhere at once. The fluorescent blue of my watch displays 3 ... Author, Article, and Disclosure InformationAffiliations: From Monash Medical Centre, Melbourne, Victoria 3165, Australia.Corresponding Author: Dr. Ranjana Srivastava, MBBS, Department of Oncology, Monash Medical Centre, East Bentleigh, Victoria 3165, Australia; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 March 2007Volume 146, Issue 6Page: 467-468KeywordsAnxietyAppendicitisChartsDrugsEmotionsNursesSleepUreterUrine ePublished: 20 March 2007 Issue Published: 20 March 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Lockerbie: why we should be proud of Al-Megrahi's doctors
Authors: J. Swire
Journal: BMJ (2010)

<h3>Objective</h3> To examine the impact of plain packaging of cigarettes with enhanced graphic health warnings on Australian adolescents’ cognitive processing of warnings and awareness of different health consequences of smoking. <h3>Methods</h3> Cross-sectional school-based surveys conducted in 2011 (prior to introduction of standardised packaging, n=6338) and 2013 (7–12 months afterwards, n=5915). Students indicated frequency of attending to, reading, thinking or talking about warnings. Students viewed a list of diseases or health effects and were asked to indicate whether each was caused by smoking. Two—‘kidney and bladder cancer’ and ‘damages gums and teeth’—were new while the remainder had been promoted through previous health warnings and/or television campaigns. The 60% of students seeing a cigarette pack in previous 6 months in 2011 and 65% in 2013 form the sample for analysis. Changes in responses over time are examined. <h3>Results</h3> Awareness that smoking causes bladder cancer increased between 2011 and 2013 (p=0.002). There was high agreement with statements reflecting health effects featured in previous warnings or advertisements with little change over time. Exceptions to this were increases in the proportion agreeing that smoking was a leading cause of death (p&lt;0.001) and causes blindness (p&lt;0.001). The frequency of students reading, attending to, thinking or talking about the health warnings on cigarette packs did not change. <h3>Conclusions</h3> Acknowledgement of negative health effects of smoking among Australian adolescents remains high. Apart from increased awareness of bladder cancer, new requirements for packaging and health warnings did not increase adolescents’ cognitive processing of warning information.
Molecular Biology of the Pituitary Gonadotropins
Authors: SOHEYLA D. GHARIB, MARGARET E. WIERMAN, MARGARET A. SHUPNIK, WILLIAM W. CHIN
Journal: Endocrine Reviews (1990)

THE pituitary gonadotropins, LH and FSH, play a central role in the mammalian reproductive process. Synthesized in the gonadotropes of the pituitary, the gonadotropins bind to receptors in the gonads leading to effects on steroidogenesis and gametogenesis (Fig. 1). Because these hormones are responsible for sexual maturation and normal reproductive function, the regulation of their synthesis and secretion is essential for the preservation of a species. In recent years, a great deal has been learned about the regulation of synthesis of the gonadotropins using the tools of molecular biology. Before we can fully appreciate these new insights, however, it is important to understand the complex structure of the gonadotropins and to summarize what is known about the regulation of their secretion. In this review, we will discuss the structure of the gonadotropin subunits, the structure of the genes that encode them, and the regulation of their secretion and synthesis.
The management of HCV infected pregnant women and their children European paediatric HCV network
Authors: Lucy Pembrey, Marie-Louise Newell, Pier-Angelo Tovo, None the EPHN Collaborators
Journal: Journal of Hepatology (2005)

As evidence accumulates relating to mother-to-child (vertical) transmission of hepatitis C virus (HCV), it is timely to draw up guidelines for the clinical management of HCV infected pregnant women and their children.A review of evidence from the European Paediatric HCV Network (EPHN) prospective study of HCV infected women and their children and other published studies. Meeting of EPHN clinical experts to reach a consensus on recommendations for management. Each recommendation was graded according to the level of evidence.Although several risk factors for mother-to-child transmission have been identified, none are modifiable and there are currently no interventions available to prevent vertical transmission of HCV. Data on timing of loss of maternal antibodies and reliability of diagnostic tests inform the optimum follow-up schedule for confirmation or exclusion of infection in children born to HCV infected women. Based on the current evidence, routine antenatal screening for HCV should not be introduced and neither elective caesarean section nor avoidance of breastfeeding should be recommended to HCV infected women to prevent mother-to-child transmission of HCV. HCV/HIV co-infected women should follow existing HIV guidelines.
Hibernating Myocardium
Authors: Albrecht Elsässer, Martin Schlepper, Wolf-Peter Klövekorn, Wei-jun Cai, René Zimmermann, Klaus-Detlef Müller, Rudolf Strasser, Sava Kostin, Christina Gagel, Brigitte Münkel, Wolfgang Schaper, Jutta Schaper
Journal: Circulation (1997)

We tested the hypothesis that hibernating myocardium represents an incomplete adaptation to a reduced myocardial oxygen supply.In 38 patients, areas of hibernating myocardium were identified by angiography, multigated radionuclide ventriculography, thallium scintigraphy with reinjection, and low-dose dobutamine echocardiography. Biopsies removed at cardiac surgery showed structural degeneration characterized by a reduced protein and mRNA expression and disorganization of the contractile and cytoskeletal proteins myosin, actin, desmin, titin, alpha-actinin, and vinculin by electron microscopy, immunohistochemistry, and in situ hybridization. Additionally, an increased amount of extracellular matrix proteins resulting in a significant degree of reparative fibrosis was present. Dedifferentiation, ie, expression of fetal proteins, was absent. Apoptosis indicating suicidal cell death was found by the terminal deoxynucleotidyl transferase end-labeling method and electron microscopy. Radionuclide ventriculography showed improvement of regional function at 3 months postoperatively compared with preoperative values (mean values, 23.5% and 48%, respectively), and the echocardiographic wall-motion score index decreased from 3.4 to 1.8. The degree of severity of the morphological changes (three stages) correlated well with the extent of postoperative functional recovery: more advanced clinical improvement was observed in patients with slight and moderate morphological degeneration (stages 1 and 2), but recovery was only partial in severe degeneration (stage 3).Cellular degeneration rather than adaptation is present in hibernating myocardium. The consequence is progressive diminution of the chance for complete structural and functional recovery after restoration of blood flow. The practical consequence from this study should be early revascularization in patients showing areas of hibernating myocardium.
Coalition says "case is made" for early assessment of prisoners' health
Authors: C. Dyer
Journal: BMJ (2010)

The UK government is committed to reforming the way that offenders in England and Wales with mental health problems and learning disabilities are dealt with, the senior official responsible for offenders’ health told a seminar in central London.

Richard Bradshaw, director of offenders’ health at the Department of Health, told a Westminster Legal Policy Forum seminar that the coalition government broadly accepted the recommendations of a report by the Labour peer Keith Bradley.

Lord Bradley’s independent review of mental health in the criminal justice system, which reported in 2009, was set up by the …
Clinical negligence claims against plastic surgeons rise "significantly"
Authors: C. Dyer
Journal: BMJ (2012)

Growing numbers of patients are launching compensation claims against plastic surgeons in private practice over operations that have gone wrong or failed to achieve the desired result, says the Medical Defence Union (MDU).

Claims against plastic surgeons are much more likely than other clinical negligence claims to result in a settlement for the patient, notes the MDU, the largest UK doctors’ defence body.

The organisation, which indemnifies doctors against malpractice allegations, refused to specify figures for the growth in plastic surgery claims, citing commercial confidentiality, but a report …
Loss of blood platelet adhesion after heating native and cultured human subendothelium to 100 Celcius
Authors: C. Borst, A. N Bos, J. J Zwaginga, R. Rienks, P. G de Groot, J. J Sixma
Journal: Cardiovascular Research (1990)

Journal Article Loss of blood platelet adhesion after heating native and cultured human subendothelium to 100° Celcius Get access Cornelius Borst, Cornelius Borst Correspondence to: Professor Borst Search for other works by this author on: Oxford Academic PubMed Google Scholar Anke N Bos, Anke N Bos Search for other works by this author on: Oxford Academic PubMed Google Scholar Jaap J Zwaginga, Jaap J Zwaginga Search for other works by this author on: Oxford Academic PubMed Google Scholar Rienk Rienks, Rienk Rienks Search for other works by this author on: Oxford Academic PubMed Google Scholar Philip G de Groot, Philip G de Groot Search for other works by this author on: Oxford Academic PubMed Google Scholar Jan J Sixma Jan J Sixma Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 24, Issue 8, August 1990, Pages 665–668, https://doi.org/10.1093/cvr/24.8.665 Published: 01 August 1990 Article history Received: 14 November 1989 Accepted: 21 March 1990 Published: 01 August 1990
Symbiotic Processes on and around a Hospital Ward
Authors: J. Foudraine
Journal: Psychotherapy and Psychosomatics (1966)

Research Articles| February 11 2010 Symbiotic Processes on and around a Hospital Ward Subject Area: Psychiatry and Psychology J. Foudraine J. Foudraine Ederveen Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1966) 14 (4): 237–250. https://doi.org/10.1159/000285828 Article history Published Online: February 11 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation J. Foudraine; Symbiotic Processes on and around a Hospital Ward. Psychother Psychosom 1 April 1966; 14 (4): 237–250. https://doi.org/10.1159/000285828 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1966Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Detection of Carotid Stenosis by Physicial Examination-Reply
Authors: Truls Østbye
Journal: JAMA (1994)

<h3>In Reply.</h3> —We thank Dr Coyle and Dr Lubic for their comments. Unfortunately, we are not aware of any rigorous studies in which the precision and accuracy of either ophthalmodynamometry or carotid bruits in diastole have been evaluated. The purpose of the series on the rational clinical examination<sup>1</sup>is to ensure that clinicians are aware of and practice examination techniques that have been demonstrated to be useful, abandon those that have not, and conduct research into those that are promising but unproven. We feel that ophthalmodynamometry and auscultation for carotid bruits in diastole fall into the last category, and we look forward to the results of methodologically rigorous studies evaluating their usefulness. If Coyle and Lubic are aware of any, we would like to hear from them.
Needs and demands for ophthalmology services
Authors: J D Huggan
Journal: BMJ (1992)

extraction we have used the prevalence of cataract in the population and the methods to which the authors refer to derive estimates of the incidence.We adjust for ethnic origin, the discrepancy between diagnostic and operative thresholds, attrition by death, and the level of contraindicated operations.Our estimates also suggest that unmet need for cataract extraction exists but they are unaffected by factors such as knowledge of, or access to, services that may distort demand incidence among elderly people.
Professor tried to get surgery stopped
Authors: C. Dyer
Journal: BMJ (1999)

Gianni Angelini, professor of cardiac surgery at Bristol University, tried to get complex heart surgery on children at Bristol stopped because “we were no good at this kind of surgery,” he told the inquiry into Bristol paediatric cardiac surgery services last week

It had been “a mistake” on his part not to have passed on to the cardiac team at Bristol an offer from Great Ormond Street Hospital in London to do the more complex operations there. But he felt that he was not in a position to influence decisions on referrals because “nobody …
Financial crisis is inevitable in the NHS by 2015-16, King's Fund says
Authors: G. Iacobucci
Journal: BMJ (2014)

A significant increase in NHS funding is needed to halt a looming financial crisis that will lead to “damaging consequences” for patient care, the King’s Fund has warned.

The NHS Productivity Challenge: Experience from the Front Line ,1 a new report published by the healthcare think tank on 1 May, argued that a financial crisis was “now inevitable by 2015-16 and could arrive sooner,” with more than a quarter of NHS trusts already in deficit.

The fund said that drastic action was required in order to deal with the crisis, and it called for honesty from all political parties about the scale of the …
Positron Emission Tomography-Based Molecular Imaging in Human Cancer
Authors: Steven M. Larson
Journal: Clinical Cancer Research (2004)

Molecular imaging in oncology is the noninvasive imaging of the key molecules and molecular-based events that are characteristic of the genotype and phenotype of human cancer. In this issue of Clinical Cancer Research , Rajendran et al. [(1)][1] exploit positron emission tomography (PET)-based
Routine Simultaneous Administration of Childhood Vaccines
Authors: Richard A. Damon
Journal: JAMA (1990)

In Reply.—  In reference to the MMR II package insert statement by Merck Sharp & Dohme, which does not recommend simultaneous administration of diphtheria, tetanus, and pertussis vaccine, oral polio vaccine, and measles vaccine because of insufficient data, we note the date of that publication to be October 1986. We suspect that this statement was based on the recommendations published by the Immunization Practices Advisory Committee (ACIP) prior to 1986, 1 when limited data were available. Since field experience and antibody data suggested there was no increased risk of adverse reactions or impaired antibody responses with simultaneous vaccinations, the ACIP recommended simultaneous vaccination when there was doubt that individuals would return to receive further doses of vaccine. In September 1986, one month prior to the publication of the Merck Sharp & Dohme package insert, the ACIP issued new recommendations based on then-unpublished data obtained from a large, randomized, double-blind trial.
Clinical Trial of Doxycycline for Matrix Metalloproteinase-9 Inhibition in Patients With an Abdominal Aneurysm
Authors: Jan H.N. Lindeman, Hazem Abdul-Hussien, J. Hajo van Bockel, Ron Wolterbeek, Robert Kleemann
Journal: Circulation (2009)

Background— Doxycycline has been shown to effectively inhibit aneurysm formation in animal models of abdominal aortic aneurysm. Although this effect is ascribed to matrix metalloproteinase-9 inhibition, such an effect is unclear in human studies. We reevaluated the effect of doxycycline on aortic wall protease content in a clinical trial and found that doxycycline selectively reduces neutrophil-derived proteases. We thus hypothesized that doxycycline acts through an effect on vascular inflammation. Methods and Results— Sixty patients scheduled for elective open aneurysmal repair were randomly assigned to 2 weeks of low-, medium-, or high-dose doxycycline (50, 100, or 300 mg/d, respectively) or no medication (control group). Aortic wall samples were collected at the time of operation, and the effect of doxycycline treatment on vascular inflammation was evaluated. Independently of its dose, doxycycline treatment resulted in a profound but selective suppression of aortic wall inflammation as reflected by a selective 72% reduction of the aortic wall neutrophils and a 95% reduction of the aortic wall cytotoxic T-cell content (median values; P &lt;0.00003). Evaluation of major inflammatory pathways suggested that doxycycline treatment specifically quenched AP-1 and C/EBP proinflammatory transcription pathways ( P &lt;0.0158, NS) and reduced vascular interleukin-6 ( P &lt;0.00115), interleukin-8 ( P &lt;0.00246, NS), interleukin-13 ( P &lt;0.0184, NS), and granulocyte colony-stimulating factor ( P &lt;0.031, NS) protein levels. Doxycycline was well tolerated; there were no adverse effects. Conclusions— A brief period of doxycycline treatment has a profound but selective effect on vascular inflammation and reduces aortic wall neutrophil and cytotoxic T-cell content. Results of this study are relevant for pharmaceutical stabilization of the abdominal aneurysm and possibly for other inflammatory conditions that involve neutrophils and/or cytotoxic T cells.
Erythrocyte Sedimentation Rate
Authors: W. O. Sykes
Journal: BMJ (1948)

corrected by the Whitby and Hynes method and in four cases corrected by the Wintrobe method readings were obtained agreeing better with the clinical course than those obtained by the Westergren technique. DiscuuuonIt has already been noted by Whitby and Hynes (1938) that the Wintrobe correction for sedimentation rates con- tains certain fallacies-i.e., that above certain figures the corrected rate is higher than the volume of packed cells, and that below certain volumes of packed cells sedimentation rates cannot be abnormal.Their own correction curve, like that of Wintrobe, is derived from estimations of rates in certain abnormal cases in which the blood was subsequently manipulated to conform to normal haematocrit readings, the Anal figures being controlled by a group of rates observed in an equivalent number of healthy students.It appears, ,kowever, from this investigation that these corrections rob the estimation of the sedimentation rate of its value.The corrected figures in the Wintrobe series often produced a series of readings which was so variable that in nearly half the cases the figures did not appear to conform to any pattern at all.The correction devised by Whitby and Hynes so levelled out the unevenness commonly found in sedimen- -ation readings, and the estimations included so many read- ings in the " doubtfully" or "slightly" raised categories, that again no pattern suggesting improvement or deteriora- tion could be detected.Beaumont and Maycock (1935) made a plea for the ingreased employment of the Westergren method as being superior to two other methods then in use, and stressed the point that useful information could be obtained only by adopting the same method in serial readings.Bailey (1941) compared the Wintrobe method with the Westergren in a series of 131 cases, and reached the conclusion that the corrected rate was of little use in classifying the patient's clinical status and was misleading in a considerable pro- portion of cases.Davis (1946) in a general review of the glinical use of sedimentation-rate estimations advocates the Westergren technique.My findings support the opinion 4hat the Westergren method, as generally used, gives figures for the sedimentation rate that agree better with the course of the patient's illness, estimated by prolonged clinical observation, than do the present methods that employ 'corrections.SummaryA study of the erythrocyte sedimentation rates of 61 female patients suffering from pulmonary tuberculosis is reported.A Zomparison was made between the clinical course of the illness on the one hand and the sedimentation rates as estimated by the methods of Westergren, Wintrobe, and Whitby and Hynes on the other.The Westergren method appeared to be the most useful both in estimating the degree of activity of the disease a-id in indicating the direction of its progress.