tbuckley/cabot-search huggingface dataset:
Coronary arterial spasm and Prinzmetal's variant form of angina induced by hyperventilation and Tris-buffer infusion.
Authors: H Yasue, M Nagao, S Omote, A Takizawa, K Miwa, S Tanaka
Journal: Circulation (1978)

Vigorous hyperventilation was induced for five minutes immediately after a five-minute infusion of 100 ml of Tris-buffer (pH 10) in nine patients with Prinzmetal's variant angina. In eight of the patients, chest pain with ischemic changes in the electrocardiogram occurred during this procedure or within five minutes after it ended. Coronary arterial spasm appeared after the procedure and disappeared after the administration of nitroglycerin in all four patients in whom coronary cinearteriography was performed. This was evident both before and after the procedure and after sublingual administration of nitroglycerin (0.6 mg). The oral administration of 90 mg of diltiazem, a calcium antagonistic drug, two hours before, completely suppressed the attack induced by the procedure in all of the five patients who received this drug. We conclude that hyperventilation plus Tris-buffer infusion induces coronary arterial spasm and anginal attack in patients with Prinzmetal's variant angina and that diltiazem suppresses these reactions.
THE INCIDENCE OF SKIN DISEASES IN THE WEST OF SCOTLAND
Authors: MARIA A. RATZER
Journal: British Journal of Dermatology (1969)

Journal Article THE INCIDENCE OF SKIN DISEASES IN THE WEST OF SCOTLAND Get access MARIA A. RATZER MARIA A. RATZER Department of Dermatology, Western Infirmary, Glasgow Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 6, 1 June 1969, Pages 456–461, https://doi.org/10.1111/j.1365-2133.1969.tb14018.x Published: 01 June 1969 Article history Accepted: 29 February 1968 Published: 01 June 1969
Submucosal Dissection of the Esophagus: A Case Report
Authors: N. Murata, T. Kuroda, S. Fujino, M. Murata, S. Takagi, M. Seki
Journal: Endoscopy (1991)

A 38-year-old male was admitted to our hospital complaining of dysphagia, sore throat and fever. An upper GI series revealed a “double-barrelled” esophagus. Endoscopic examination of the esophagus showed multiple ulcers and mucosal bridges resulting from laceration of the submucosal layer. An acute ulcer of the stomach was also found. Fasting and total parenteral nutrition for several weeks failed to bring about any changes in the endoscopic findings. As treatment, the mucosal bridges throughout the esophagus were divided with a diathermy knife under endoscopic control. Soon after the procedure, the patient's symptoms disappeared completely, and the massive dissection of the esophagus had improved except for slight depressions.
Antimicrobial resistance presents an "apocalyptic" threat similar to that of climate change, CMO warns
Authors: I. Torjesen
Journal: BMJ (2013)

Action is needed at both a national and international level to avert the “ticking time bomb” of antimicrobial resistance, which presents a threat as grave as climate change, the chief medical officer for England has warned.

In the second volume of her annual report for 2011, Infections and the rise of antimicrobial resistance ,1 Sally Davies spelt out the threat—overuse of existing antibiotics and increasing resistance to them, a “discovery void” of new antibiotics, a change in the types of organism presenting the greatest threat, and the need for better training of NHS staff in hygiene and infection control.

“If we don’t get this right we will find ourselves in a health system not dissimilar to the early 19th century,” …
Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk
Authors: Hitoshi Takizawa, Chiyomi Kubo-Akashi, Ikuo Nobuhisa, Sang-Mo Kwon, Masanori Iseki, Tetsuya Taga, Kiyoshi Takatsu, Satoshi Takaki
Journal: Blood (2005)
Hypoglycorrachia in Leptospirosis
Authors: RICHARD E. HELMER
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 December 1973Hypoglycorrachia in LeptospirosisRICHARD E. HELMER III, M.D., RALPH D. MILLSAPS, M.D.RICHARD E. HELMER III, M.D.Search for more papers by this author, RALPH D. MILLSAPS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-6-912 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Central nervous system involvement in leptospirosis has been documented (1-4). Pleocytosis and elevation of protein in the cerebrospinal fluid (CSF) are well known. The cerebrospinal fluid glucose concentration has been reported as either normal or slightly elevated (1-4); hypoglycorrachia, therefore, was of particular interest in a suspected, although unproved, case of leptospirosis (5).A 27-year-old white man from rural East Texas had been in excellent health until three weeks before admission to his local hospital, when he noticed malaise. One week earlier he had cut his leg on a submerged barbed-wire fence, when swimming a rain-swollen creek...References1. EDWARDSDOMM GB: Human leptospirosis. Medicine (Baltimore) 39:117-156, 1960 CrossrefMedlineGoogle Scholar2. TURNER L: Leptospirosis. Br Med J 1:231-235, 1969 CrossrefMedlineGoogle Scholar3. CARGILLBEESON WP: The value of spinal fluid examination as a diagnostic procedure in Weil's disease. Ann Intern Med 27:396-400, 1947 LinkGoogle Scholar4. BERMANTSAIHOLMES SCK: Sporadic anicteric leptospirosis in South Vietnam. Ann Intern Med 79:167-173, 1973 LinkGoogle Scholar5. SANFORD J: Leptospirosis, in Cecil-Loeb Textbook of Medicine, 13th ed., edited by BEESON PB, MCDERMOTT W. Philadelphia, W. B. Saunders Co., 1971, pp. 680-683 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Internal Medicine University of Texas Medical Branch Galveston, Texas PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLeptospirosis en un área sanitaria del suroeste españolLeptospirosis in South-western SpainSpirochaetal infections of the nervous system 1 December 1973Volume 79, Issue 6Page: 912-912KeywordsAttentionCentral nervous systemCerebrospinal fluidColony stimulating factorGlucoseLeptospirosisLeukocytosisProteinsSwimming Issue Published: 1 December 1973 PDF DownloadLoading ...
Treatment of Laryngitis.
Authors: W. B. Shields
Journal: JAMA (1901)

St. Louis, July 24, 1901. <h3>To the Editor:</h3> —In an article on "The Treatment of Laryn. gitis," which appeared inThe Journalof July 20, page 180, the author, in speaking of pachyderma laryngitis, ascribes the salicylic acid method of treatment to Fein. If I mistake not, Dundas Grant was the first laryngologist to advocate this method of treatment in 1897, and I am under the impression that Fein gives Grant credit for first advocating this method. Several years ago I had the privilege of seeing Grant treat a number of these cases thus, with most excellent results. Grant's method of treating these cases and results can be found in an article by him in the<i>Journal of Laryngology, Rhinology and Otology</i>, October, 1899. Very truly,
Where Does &lt;EMPH TYPE="ITAL"&gt;Helicobacter pylori&lt;/EMPH&gt; Come From and Why Is It Going Away?
Authors: Martin J. Blaser
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Identification and isolation of a Fel d 1–like molecule as a major rabbit allergen
Authors: Christiane Hilger, Stéphanie Kler, Karthik Arumugam, Dominique Revets, Claude P. Muller, Catherine Charpentier, Christiane Lehners, Martine Morisset, François Hentges
Journal: Journal of Allergy and Clinical Immunology (2013)
A NEW OPERATION FOR THE RELIEF OF SEVERE CASES OF RECTO-VAGINAL FISTULA.
Authors: A. PALMER DUDLEY
Journal: JAMA (1902)

Some months ago I read an article before the New York Obstetrical Society giving simply a short description, accompanied by some drawings (for which I expressed my gratitude to Dr. John Aspell of New York) of an operation which I devised while delivering my course of lectures at Dartmouth Medical College last year. I, at that time, presumed to designate it as "Dudley's Operation for the Relief of Severe Cases of Recto-Vaginal Fistula," because, so far as I was able to learn, in looking over the record of such cases at hand, it was original with myself and rather unique in procedure; nevertheless it was successful, and, in my judgment, it will in the future receive recognition from the profession, and take its place as a surgical relief for such a condition. As that article has never been published, except in abstract, I may be permitted to again give a
Serum bactericidal and opsonic activities in chronic lymphocytic leukemia and multiple myeloma
Authors: Emin Kansu, Erdal Akalin, Cahid Civelek, Oktay Tekesin, Yahya Lalell, Dinçer Firat
Journal: American Journal of Hematology (1986)

Abstract Susceptibility to infection is widely recognized as the major cause of morbidity and mortality in patients with CLL and MM. The present study was designed to investigate the serum bactericidal (SBA) and serum opsonic activities (SOA) in 12 CLL and 12 MM patients, and results were compared to 20 normals. SBA and SOA were measured by a new radiometric assay. SBA was found to be normal in 11 patients with CLL and in all 12 patients with MM. In contrast, SOA was significantly lower in 11 out of 12 patients with CLL. Ten of twelve patients with MM also had significantly lower SOA compared to those of controls. No correlation was detected between the serum immunoglobulin and complement levels of the patients or between the degree of the opsonic defect and the incidence of infection. In mixture experiments, untreated normal serum partially corrected the opsonic activity of CLL and MM serum. The results suggest the presence of a possible inhibitor in the serum of patients with two well‐known B‐lymphocyte‐derived disorders.
PD-1/SHP-2 negatively regulate Tc1/Th1 phenotypic responses and activation of T cells in the tumor microenvironment
Authors: Jing Li, Robert L Ferris
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Rejection of tumor cells by a robust cellular immune response relies on production of type 1 cytokines (such as IFN-γ) and cytolytic activity of T cells. Programmed Death 1 (PD-1), a co-inhibitory receptor proposed to represent T cell dysfunction, is highly expressed on tumor
Abstract 3723: Tangeretin enhances sensitivity of human pancreatic cancer cells to gemcitabine through targeting the reprogramming of stemness.
Authors: Inamul Haque, Sushanta K. Banerjee, Snigdha Banerjee
Journal: Cancer Research (2013)

Abstract Background: As a single agent, gemcitabine (2′,2′-difluorodeoxycytidine) has shown only a modest improvement in survival in patients with pancreatic ductal adenocarcinoma (PDAC). Our recent studies found CCN1 (a member of CCN family of growth factor) as an important factor in determining PDAC aggressiveness as it promotes epithelial to mesenchymal transition, tumor stemness, migration and tumorigenicity in xenograft model, possibly through the regulation of multiple miRNAs that are known to link with the progression of cancers and survival and the maintenance of cancer stem cells. Targeting CCN1 may lead to the development of novel therapeutic approaches for human cancers. Here, we examined the effects of tangeretin, a polymethoxylated flavonoid compound produced by citrus fruits in combination of gemcitabine on CCN1-sonic hedgehog (SHh) signaling in pancreatic cancer cells, and assessed the therapeutic potential of tangeretin with gemcitabine for the treatment and/or prevention of pancreatic cancer. Methodology/Principal Findings: Cell viability and apoptosis were measured by crystal violet staining assay and annexinV/PI staining assay, respectively. Gene and protein expressions were measured by Western blot analysis, respectively. We found that tangeretin in combination with gemcitabine significantly decreased cell survival, clonogenicity, wound-healing capacity, sphere-forming capacity (pancreatospheres) in pancreatic cell lines. Tangeretin also decreased the expression of cancer stem cells (CSC) markers, CD44, Notch-1, Nanog, Oct-4, ABCG2, SHh and CCN1. Conclusions: Collectively, these studies clearly suggest that tangeretin helps in sensitizing pancreatic cancer cells to gemcitabine by reprogramming the CSC-specific markers. Thus tangeretin could be useful for overcoming therapeutic resistance of pancreatic cancer cells. Citation Format: Inamul Haque, Sushanta K. Banerjee, Snigdha Banerjee. Tangeretin enhances sensitivity of human pancreatic cancer cells to gemcitabine through targeting the reprogramming of stemness. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3723. doi:10.1158/1538-7445.AM2013-3723
Serum bile acids and alanine aminotransferase concentrations. Comparison of efficacy as indirect means of identifying carriers of non-A, non-B hepatitis agents and of onset, severity, and duration of posttransfusion non-A, non-B hepatitis in recipients
Authors: J. M. Mishler
Journal: JAMA (1981)

Indirect tests of liver function such as determinations of concentrations of alanine aminotransferase (ALT) and conjugated bile acids (BA) have been advocated as indicators of both the infectivity of the blood of donors in transmitting non-A, non-B (NANB) hepatitis and of the onset, severity, and duration of this disease in recipients. We therefore compared the predictive value of concentrations of ALT and postprandial concentrations of BA in the blood of 311 donors and in the blood of 41 recipients in whom either NANB or type B hepatitis developed after transfusion. Our results demonstrated that higher than normal concentrations of ALT (&gt;45 IU/L) in the blood of donors were generally accompanied with normal concentrations of BA (&lt;6 μmole/L). and, therefore, concentrations of ALT may be more useful in predicting the infectivity of donor blood in transmitting NANB hepatitis. In addition, concentrations of ALT, compared with BA concentrations, were a significantly better indicator of the onset, severity, and duration of the disease in recipients in whom NANB hepatitis developed after transfusion. In recipients who had posttransfusion type B hepatitis, serum concentrations of ALT were significantly better indicators of the onset and severity of the disease than concentrations of BA. (<i>JAMA</i>1981;246:2340-2344)
Treatment of Salmonella Infections
Authors: JOHN V. BENNETT
Journal: Annals of Internal Medicine (1979)

Letters1 October 1979Treatment of Salmonella InfectionsJOHN V. BENNETT, M.D., ROGER A. FELDMAN, M.D.JOHN V. BENNETT, M.D.Search for more papers by this author, ROGER A. FELDMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-4-654 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their article "The Risks of Endothelial Infection in Adults with Salmonella Bacteremia" in the December 1978 issue (1), Cohen and co-workers state that antibiotics may be indicated for treatment of acute salmonella gastroenteritis in patients older than age 50 to prevent complications of possible salmonella bacteremia. We are writing to discuss this suggestion and to seek clarification of several issues not completely addressed in the article.The patients in their 10 cases were all older than 50 years of age and had "evidence of infection" (presumably endothelial infection) before admission, and four of these 10 had...References1. COHEN P, O'BRIEN T, SCHOENBAUM S, and MEDEIROS A. The risk of endothelial infection in adults with salmonella bacteremia. Ann Intern Med. 1979;89:931-2. LinkGoogle Scholar2. HORNICK R, GREISMAN S, WOODWARD T, DUPONT H, DAWKINS A, and SNYDER M: Typhoid fever: pathogenesis and immunologic control. N Engl J Med. 1970;283:686-91, 739-46. CrossrefMedlineGoogle Scholar1. COHEN P, O'BRIEN T, SCHOENBAUM S, and MEDEIROS A. The risk of endothelial infection in adults with salmonella bacteremia. Ann Intern Med 1978;89:931-2. LinkGoogle Scholar2. HORNICK R, GREISMAN S, WOODWARD T, DUPONT H, DAWKINS A, and SNYDER M. Typhoid fever: pathogenesis and immunologic control. N Engl J Med. 1970;283:686-91, 739-46. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN V. BENNETT, M.D.; ROGER A. FELDMAN, M.D.Affiliations: Center for Disease Control Atlanta, GA 30333 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLes artérites aigües distales au cours des salmonellosesSeptic arteritis complicating salmonellosis. 1 October 1979Volume 91, Issue 4Page: 654-655KeywordsAntibioticsBacteremiaGastroenteritisSalmonella ePublished: 1 December 2008 Issue Published: 1 October 1979 PDF downloadLoading ...
Molecular Diagnostics for Gonorrhoea: Implications for Antimicrobial Resistance and the Threat of Untreatable Gonorrhoea
Authors: Nicola Low, Magnus Unemo, Jørgen Skov Jensen, Judith Breuer, Judith M. Stephenson
Journal: PLoS Medicine (2014)

This Essay from Nicola Low and colleagues discusses the importance of the nucleic acid amplification tests for rapid detection of N. gonorrhoeae and its resistance determinants, as well as the importance of ensuring their rational use, as priorities for controlling both gonorrhoea and antimicrobial resistance. Please see later in the article for the Editors' Summary
Rhinitis and Inhalant Allergens
Authors: Robert Naclerio, William Solomon
Journal: JAMA (1997)

Allergic rhinitis affects about 20% of the US population. The diagnosis is based on patterns of symptoms, physical examination, and assessment of IgE antibodies by skin or in vitro testing. The most common offending allergens are pollens of grasses, trees, and weeds; fungi; animal allergens; and dust mites. In an individual with nasal allergy, exposure leads to rapid release of mast cell-derived mediators. This immediate response is followed by a cell-dominated response, including eosinophils and lymphocytes. Cytokines from T(H)2 lymphocytes, such as interleukin 4 and interleukin 5, orchestrate allergic inflammation. Resulting tissue changes produce symptoms of the disease and augment responses on subsequent exposure to allergens and irritants. Strategies for avoiding offending agents are important in management. In intermittent disease, antihistamines and/or decongestants are first prescribed. More continuous symptoms may mandate intranasal steroids. Immunotherapy is often helpful for patients who respond poorly to pharmacotherapy and avoidance.
Coronary atherosclerosis in subjects with mitral stenosis.
Authors: S M Tadavarthy, Z Vlodaver, J E Edwards
Journal: Circulation (1976)

The coronary arteries were examined in 60 specimens from patients with mitral stenosis. In three, localized obstruction was nonatherosclerotic in nature (in one, arterial dysplasia; in two, embolic). In 18 of the remaining 57 cases (31.5%), significantly obstructive atherosclerosis in one or more segments of the coronary arterial system was found. This represented 46% of the males and 27% of the females. The incidence of involvement of three or more arteries by significantly obstructive atherosclerosis was 39%, while in a cited series of subjects with angina pectoris three or more vessels were involved in 79% of the cases. It may be concluded that, on the average, the distribution of lesions in patients with mitral stenosis and significant coronary atherosclerosis is less wide than in subjects with clinical coronary disease.
Bornholm Disease in Children
Authors: M. E. Disney, E. M. Howard, B. S. B. Wood
Journal: BMJ (1953)

Orchitis was a complication in 3 out of 30 adult males infected.Relapses, both early and late, were a characteristic feature of the outbreak.Viruses pathogenic for infant mice were isolated from the faeces of 6 out of 17 cases examined.Attempts to isolate virus from C.S.F., blood, and throat washings failed.The strain of Coxsackie virus isolated was identified as belonging to Dalldorf's Group B on account of the pathological lesions in mice.These included muscle, fat-pad, and cerebral lesions in infant mice, and extensive lesions of the acinar tissue of the pancreas in adult mice.Paired acute and convalescent sera were obtained from 13 patients and tested for the presence of neutral- izing antibody against the Oxford virus.A marked rise in neutralizing power in the convalescent serum was demonstrated in eight patients, whilst the other five cases had a high titre of antibody in both sera.Preliminary cross-neutralization tests, using the Oxford virus, indicate that it may be a previously unrecognized antigenic type.The laboratory investigation of the Oxford epidemic of Born- holm disease was made possible by the generosity of the Nuffield Foundation, to whom we wish to express our gratitude.Our thanks are due to
US bans doctors from conference in Cuba
Authors: Lynn Eaton
Journal: BMJ (2004)

US medics and scientists are furious at a decision by the US government to refuse them licences to attend an international medical conference in Cuba last month, despite the fact that in previous years such visits had been allowed.

The conference on coma and death is held every four years in Havana—this year from 9 to 12 March. It had become one of the best international conferences on the subject, according to Professor Stuart Younger from the Department of Bioethics, Case Western Reserve University, Cleveland, Ohio, who had been due to attend and present a paper on attitudes of the US public to brain death.

“I attended the 1992, 1996, and 2000 meetings with no …