Detection of a Clonal BCL2 Gene Rearrangement in Tissues from a Patient with Whipple Disease
Authors: Thierry Fest
Journal: Annals of Internal Medicine (1996)

Brief Communications15 April 1996Detection of a Clonal BCL2 Gene Rearrangement in Tissues from a Patient with Whipple DiseaseThierry Fest, MD, Benedicte Pron, MD, Marie-Paule Lefranc, PhD, Catherine Pierre, MD, Regis Angonin, MD, Benoit de Wazieres, MD, Zohra Soua, MD, and Jean-Louis Dupond, MDThierry Fest, MDFrom Hopital Universitaire Jean Minjoz, Besancon, France; Hopital Necker-Enfants Malades, Paris, France; and Institut de Genetique Moleculaire, Montpellier, France.Search for more papers by this author, Benedicte Pron, MDFrom Hopital Universitaire Jean Minjoz, Besancon, France; Hopital Necker-Enfants Malades, Paris, France; and Institut de Genetique Moleculaire, Montpellier, France.Search for more papers by this author, Marie-Paule Lefranc, PhDFrom Hopital Universitaire Jean Minjoz, Besancon, France; Hopital Necker-Enfants Malades, Paris, France; and Institut de Genetique Moleculaire, Montpellier, France.Search for more papers by this author, Catherine Pierre, MDFrom Hopital Universitaire Jean Minjoz, Besancon, France; Hopital Necker-Enfants Malades, Paris, France; and Institut de Genetique Moleculaire, Montpellier, France.Search for more papers by this author, Regis Angonin, MDFrom Hopital Universitaire Jean Minjoz, Besancon, France; Hopital Necker-Enfants Malades, Paris, France; and Institut de Genetique Moleculaire, Montpellier, France.Search for more papers by this author, Benoit de Wazieres, MDFrom Hopital Universitaire Jean Minjoz, Besancon, France; Hopital Necker-Enfants Malades, Paris, France; and Institut de Genetique Moleculaire, Montpellier, France.Search for more papers by this author, Zohra Soua, MDFrom Hopital Universitaire Jean Minjoz, Besancon, France; Hopital Necker-Enfants Malades, Paris, France; and Institut de Genetique Moleculaire, Montpellier, France.Search for more papers by this author, and Jean-Louis Dupond, MDFrom Hopital Universitaire Jean Minjoz, Besancon, France; Hopital Necker-Enfants Malades, Paris, France; and Institut de Genetique Moleculaire, Montpellier, France.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-8-199604150-00006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Whipple disease is rare and has protean clinical manifestations that often mimic those of other pathologic conditions. Because no culture system for the causative organism exists, the diagnosis is made after microscopic examination of infected tissue. If the results of this examination are positive, small gram-positive rods appear as diastase-resistant intracytoplasmic inclusions on periodic acid-Schiff staining. The polymerase chain reaction (PCR) assay has recently been shown to be useful in confirming the diagnosis [1].Whipple disease is rarely associated with the subsequent development of lymphoma, although the two may be related. We report a case in which a BCL2 rearrangement ...References1. Rickman LS, Freeman WR, Green WR, Feldman ST, Sullivan J, Russack V, et al. Brief report: uveitis caused by Tropheryma whippelii (Whipple's bacillus). N Engl J Med. 1995; 332:363-6. Google Scholar2. Relman DA, Schmidt TM, MacDermott RP, Falkow S. Identification of the uncultured bacillus of Whipple's disease. N Engl J Med. 1992; 327:293-301. Google Scholar3. 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Whipple's disease: a histological, immunocytochemical and electronmicroscopic study of the immune response in the small intestinal mucosa. Histopathology. 1992; 21:1-12. Google Scholar8. Gillen CD, Coddington R, Monteith PG, Taylor RH. Extraintestinal lymphoma in association with Whipple's disease. Gut. 1993; 34:1627-9. Google Scholar9. von Herbay A, Otto HF. [Abdominal lymphoma in Whipple's disease (Letter)]. Dtsch Med Wochenschr. 1989; 114:2028. Google Scholar10. Stolte M, Eidt S. Lymphoid follicles in the antral mucosa: immune response to Campylobacter pylori. J Clin Pathol. 1989; 42:1269-71. Google Scholar11. Wotherspoon AC, Doglioni C, Diss TC, Pan L, Moschini A, de Boni M, et al. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet. 1993; 342:575-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: From Hopital Universitaire Jean Minjoz, Besancon, France; Hopital Necker-Enfants Malades, Paris, France; and Institut de Genetique Moleculaire, Montpellier, France.Acknowledgments: The authors thank Francoise Ducret for technical assistance.Grant Support: By the Centre National de la Recherche Scientifique, the Ministere de l'Enseignement Superieur et de la Recherche, the Institut National de la Sante et de la Recherche, and the Ministere de l'Education et des Sciences de Tunisie.Corresponding Author: Thierry Fest, MD, Laboratory of Pathology, National Cancer Institute, 9000 Rockville Pike, Building 10, Room 2N109, Bethesda, MD 20892.Current Author Addresses: Dr. Fest: Laboratory of Pathology, National Cancer Institute, 9000 Rockville Pike, Building 10, Room 2N109, Bethesda, MD 20892. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByWhipple's DiseaseReactive Lymphadenopathy with Sinus PatternTropheryma whipplei Crystalline Keratopathy: Report of a Case and Updated Review of the LiteratureWhipple DiseaseImmunosuppressive Therapy in Whipple's Disease Patients is Associated with the Appearance of Gastrointestinal ManifestationsSystemic Tropheryma whippleii Infection Associated With Monoclonal B-Cell Proliferation: A Helicobacter pylori –Type Pathogenesis?Whipple's Disease and “ Tropheryma whippelii ”Infection, Immunity, and CancerOf what use is molecular biology to the practicing radiation oncologist? 15 April 1996Volume 124, Issue 8Page: 738-740KeywordsAntibioticsAntigensBloodBone marrowCellsDNALymph nodesLymphomaSouthern blotT cell receptors Issue Published: 15 April 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...