Treatment of Severe Orthostatic Hypotension by Metoclopramide
Authors: OTTO KUCHEL
Journal: Annals of Internal Medicine (1980)

Brief Reports1 December 1980Treatment of Severe Orthostatic Hypotension by MetoclopramideOTTO KUCHEL, M. D., Sc.D., NGUYEN T. BUU, Ph.D., JOLANTA GUTKOWSKA, Ph. D., JACQUES GENEST, M.D., D.ScOTTO KUCHEL, M. D., Sc.D., NGUYEN T. BUU, Ph.D., JOLANTA GUTKOWSKA, Ph. D., JACQUES GENEST, M.D., D.ScAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-6-841 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe cardiovascular consequences of a deficient release of norepinephrine at nervous terminals are dependent on its balance with some vasodilator and natriuretic substances (bradykinin, some prostaglandins, and dopamine [for review see Reference I]) whose action is opposite that of norepinephrine. Treatment by substances that inhibit bradykinin and prostaglandin action or synthesis proved effective in many cases of orthostatic hypotension (2). We have reported (3) that in severe orthostatic hypotension with increased urinary dopamine excretion the condition has been considerably improved by treatment with carbidopa, a peripheral inhibitor of dopamine synthesis. The introduction of an assay for conjugated dopamine in plasma...References1. KUCHELBUUUNGER ONT. Dopamine-sodium relationship: is dopamine a part of the endogenous natriuretic system? Contrib Nephrol. 1978;13:27-36. CrossrefMedlineGoogle Scholar2. CRYER P. Mechanisms and management of postural hypotension. In: COHEN MP, FOÀ PP, eds. Special Topics in Endocrinology and Metabolism, vol. 1. New York: Alan R. Liss, Inc., 1979:79-91. Google Scholar3. LEBELKUCHELBARBEAU MOA. Excès de dopamine dans l'hypotension orthostatique postsympathectomie: traitement par un inhibiteur de la dopa-décarboxylase. Union Med Can. 1973;102:819-25. MedlineGoogle Scholar4. BUUKUCHEL NO. A new method for the hydrolysis of conjugated catecholamines. J Lab Clin Med. 1977;90:680-5. MedlineGoogle Scholar5. STUMPEKOLLOCHHIGUCHI KRM. Hyperprolactinaemia and antihypertensive effect of bromocriptine in essential hypertension: identification of abnormal central dopamine control. Lancet. 1977;2:211-4. CrossrefMedlineGoogle Scholar6. CORVOLBISSELICHESALEXANDRE PFJ. Poussées hypertensives déclenchées par le sulpiride. Sem Hôp Paris. 1974;50:1265-9. MedlineGoogle Scholar7. VON EULERFRANKSSONHELLSTRÖM UCJ. Adrenaline and noradrenaline output in urine after unilateral and bilateral adrenalectomy in man. Acta Physiol Scand. 1954;31:1-5. CrossrefMedlineGoogle Scholar8. KUCHELBUUFONTAINE ONA. Free and conjugated plasma catecholamines in hypertensive patients with and without pheochromocytoma. Hypertension. 1980;2:177-86. CrossrefMedlineGoogle Scholar9. GOLDBERG L. Dopamine—clinical uses of an endogenous catecholamine. N Engl J Med. 1974;291:707-10. CrossrefMedlineGoogle Scholar10. CAREYTHORNERORTT RME. Effects of metoclopramide and bromocriptine on the renin-angiotensin-aldosterone system in man: dopaminergic control of aldosterone. J Clin Invest. 1979;63:727-35. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Clinical Research Institute HÔtel-Dieu Hospital, University of Montreal Montreal, Quebec, Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDisorders of the Autonomic Nervous SystemPostural HypotensionSymptomatic postural hypotension in diabetes: aetiology and managementTreatment of Patients With Orthostatic Hypotension and SyncopeThe cardiovascular effects of metoclopramide in multiple system atrophy and pure autonomic failureOrthostatic Hypotension in Patients with Parkinson??s DiseaseManagement of postural hypotensionIdiopathic hypovolemia: a self-perpetuating autonomic dysfunction?Which drug for which orthostatic hypotension?Neurogenic orthostatic hypotension: A double-blind, placebo-controlled study with midodrineAbnormalities of systemic blood pressure in diabetes mellitusHaemodynamic and neurohumoral responses in elderly patients with postural hypotensionTherapeutic management of nausea and vomitingOrthostatic Hypotension: Therapeutic Alternatives for Geriatric PatientsCoping with autonomic neuropathyClinical aspects of diabetic neuropathiesDopamine in Dopamine-β-Hydroxylase DeficiencyDiabetic Peripheral NeuropathiesYADOLLAH HARATI, M. D.Management of peripheral neuropathy in diabetes mellitusDisorders of the autonomic nervous system: Part 2. investigation and treatmentIsolated Failure of Autonomic Noradrenergic NeurotransmissionManagement of chronic orthostatic hypotensionDiabetic autonomic neuropathyMetoclopramide — a reviewPotential Uses for MetoclopramideOrthostatic Hypotension: A Posture-Induced Hyperdopaminergic StateTreatment of chronic orthostatic hypotension with ergotamine.Metoclopramide: Pharmacology and Clinical ApplicationRIYAD ALBIBI, M.D., RICHARD W. McCALLUM, M.D.Metoclopramide alone or combined with flurbiprofen in the treatment of orthostatic hypotension associated with diabetes mellitusManagement of Orthostatic HypotensionMetoclopramide 1 December 1980Volume 93, Issue 6Page: 841-843KeywordsBlood plasmaDopamineEpidermal growth factorExcretionHypertensionHypotensionNatriuretic peptidesNorepinephrineProstaglandinsVasodilators Issue Published: 1 December 1980 PDF DownloadLoading ...