tbuckley/cabot-search huggingface dataset:
Psoriasis, nails, joints and autoimmunity
Authors: P.V. Harrison, K. Khunti, J.A. Morris
Journal: British Journal of Dermatology (1990)

Journal Article Psoriasis, nails, joints and autoimmunity Get access P.V. Harrison, P.V. Harrison Department of Dermatology, Beaumont Hospital, Lancaster LA1 2JF, U.K. Search for other works by this author on: Oxford Academic Google Scholar K. Khunti, K. Khunti Department of Dermatology, Beaumont Hospital, Lancaster LA1 2JF, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.A. Morris J.A. Morris Department of Pathology, Lancaster Moor Hospital, Lancaster LA1 3JR, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 122, Issue 4, 1 April 1990, Pages 569–572, https://doi.org/10.1111/j.1365-2133.1990.tb14736.x Published: 01 April 1990
Easing some burden for future Burden of Disease studies: lessons learnt from the Global Burden of Disease 2010 Study—the Musculoskeletal Expert Group's point of view
Authors: Emma U R Smith, Fiona Blyth, Damian Hoy, Marita Cross, Lidia Sanchez Riera, Rachelle Buchbinder, Richard Osborne, Anthony Woolf, Lyn March
Journal: The Lancet (2013)
Studies on Antibody to Intrinsic Factor *
Authors: Stanley G. Schade, Johannes Abels, Robert F. Schilling, Patricia Feick, Mary Muckerheide
Journal: Journal of Clinical Investigation (1967)

Sera from a group of 79 patients with pernicious anemia were studied for the presence of antibody to intrinsic factor. Two general types of antibody activity were found, and it was possible to distinguish three groups of pernicious anemia sera on the basis of their content of these types. Type I antibody blocks the binding of radioactive vitamin B(12) to intrinsic factor when added to intrinsic factor before the B(12); it is not detected on intrinsic factor when added after B(12). This antibody blocks intrinsic factor-mediated B(12) absorption in vivo when mixed in the sequence intrinsic factor + antibody I + B(12), but not when mixed in the sequence intrinsic factor + B(12) + antibody I. Type II antibody reacts with intrinsic factor when B(12) is attached. This antibody prevents the absorption of B(12) from intrinsic factor in pernicious anemia patients when mixed in the sequence intrinsic factor + B(12) + antibody II, and is thereby distinguished from antibody I.
The Banff 97 working classification of renal allograft pathology
Authors: Lorraine C. Racusen, Kim Solez, Robert B. Colvin, Stephen M. Bonsib, Maria C. Castro, Tito Cavallo, Byron P. Croker, A. Jake Demetris, Cynthia B. Drachenberg, Agnes B. Fogo, Peter Furness, Lillian W. Gaber, Ian W. Gibson, Dennis Glotz, Julio C. Goldberg, Joseph Grande, Philip F. Halloran, H.E. Hansen, Barry Hartley, Pekka J. Hayry, Claire M. Hill, Ernesto O. Hoffman, Lawrence G. Hunsicker, Anne S. Lindblad, Niels Marcussen, Michael J. Mihatsch, Tibor Nadasdy, Peter Nickerson, T. Steen Olsen, John C. Papadimitriou, Parmjeet S. Randhawa, David C. Rayner, Ian Roberts, Stephen Rose, David Rush, Luis Salinas-Madrigal, Daniel R. Salomon, Stale Sund, Eero Taskinen, Kiril Trpkov, Yutaka Yamaguchi
Journal: Kidney International (1999)

Standardization of renal allograft biopsy interpretation is necessary to guide therapy and to establish an objective end point for clinical trials. This manuscript describes a classification, Banff 97, developed by investigators using the Banff Schema and the Collaborative Clinical Trials in Transplantation (CCTT) modification for diagnosis of renal allograft pathology.Banff 97 grew from an international consensus discussion begun at Banff and continued via the Internet. This schema developed from (a) analysis of data using the Banff classification, (b) publication of and experience with the CCTT modification, (c) international conferences, and (d) data from recent studies on impact of vasculitis on transplant outcome.Semiquantitative lesion scoring continues to focus on tubulitis and arteritis but includes a minimum threshold for interstitial inflammation. Banff 97 defines "types" of acute/active rejection. Type I is tubulointerstitial rejection without arteritis. Type II is vascular rejection with intimal arteritis, and type III is severe rejection with transmural arterial changes. Biopsies with only mild inflammation are graded as "borderline/suspicious for rejection." Chronic/sclerosing allograft changes are graded based on severity of tubular atrophy and interstitial fibrosis. Antibody-mediated rejection, hyperacute or accelerated acute in presentation, is also categorized, as are other significant allograft findings.The Banff 97 working classification refines earlier schemas and represents input from two classifications most widely used in clinical rejection trials and in clinical practice worldwide. Major changes include the following: rejection with vasculitis is separated from tubulointerstitial rejection; severe rejection requires transmural changes in arteries; "borderline" rejection can only be interpreted in a clinical context; antibody-mediated rejection is further defined, and lesion scoring focuses on most severely involved structures. Criteria for specimen adequacy have also been modified. Banff 97 represents a significant refinement of allograft assessment, developed via international consensus discussions.
THE RADIOLOGY OF LIVING ANATOMY
Authors: J. F. Brailsford
Journal: BMJ (1934)

When I was trained as a medical student, a great many years ago, I had to learn my anatomy on the dead body.But we may now, by means of x rays, learn in the ideal way (which we thought of in those far-off days as impossible to reach) of the anatomy of the liviIng body; ideal, because all the tissues of the human frame are different in the dead body from what they are in the iiving.The x ray has, therefore, real weight in the study of human anatomy, of anatomy, not as it lies in dust and ashes, but as a living entity, the crown and summit of nature, the greatest thing as far as we know that has been created, on this planet at all events, if not in the whole universe."Radiological study of the living body has contributed considerably to our knowledge of anatomy, but such knowledge must be regarded as supplementary to that which can be obtained in the dissecting room only.It is dependent on the relative density of the tissues or organs and their contents to x rays, and is in fact a study of shadows.While in the case of radiographs of the bones or of the lungs detail of the delicate structure can be portrayed, in most cases we have to base our knowledge on the internal or external contour of the organ.By the aid of substances of a lesser or greater density than the surrounding tissues we are able to show the outline of the interior of every tubular viscus.
411 A NEW HBsAg/ANTI-HBs IMMUNE COMPLEX ASSAY PREDICTS HBeAG LOSS IN CHRONIC HEPATITIS B PATIENTS
Authors: A. de Niet, H.L. Zaaijer, U. Klause, L. Jansen, B. Takkenberg, H.L.A. Janssen, T. Chu, R. Petric, H.W. Reesink
Journal: Journal of Hepatology (2013)
Echocardiography in the Management of Pulmonary Embolism
Authors: Samuel Z. Goldhaber
Journal: Annals of Internal Medicine (2002)

Echocardiography is not recommended as a routine imaging test to diagnose suspected pulmonary embolism. However, it is useful for identifying patients with pulmonary embolism who may have a poor prognosis. It can be used for rapid and accurate risk assessment. Moderate or severe right ventricular hypokinesis, persistent pulmonary hypertension, a patent foramen ovale, and free-floating right-heart thrombus are echocardiographic markers that identify patients at risk for death or recurrent thromboembolism. Such patients warrant consideration for thrombolysis or embolectomy. Serial imaging of right ventricular function can help physicians monitor the effect of treatment and judge whether the selected management strategy is successful. Further research will clarify and define more precisely the utility and limitations of echocardiography in the management of pulmonary embolism.
Buprenorphine May Boost HIV Treatment
Authors: Bridget M. Kuehn
Journal: JAMA (2010)

creases in PEPFAR funding during the program’s early years helped create “a huge amount of enthusiasm for having 6 to 10 million on treatment by 2014 or 2013.” Now, she said, level funding and economic woes have blunted that enthusiasm. At the same time, however, Walensky credits PEPFAR with essentially creating a health care infrastructure in many developing countries and focusing global attention on the need for stronger health care systems in resource-limited regions. “How we prioritize what funds go into what places is going to be our global challenge for years to come.”
Comparative Usefulness of Qualitative and Quantitative Stool Occult Blood Tests in the Diagnosis of Gastrointestinal Disease.
Authors: F. G. Ebaugh
Journal: Annals of Internal Medicine (1961)

s1 May 1961Comparative Usefulness of Qualitative and Quantitative Stool Occult Blood Tests in the Diagnosis of Gastrointestinal Disease.F. G. Ebaugh Jr., M.D., F.A.C.P., W. Beeken, M.D.F. G. Ebaugh Jr., M.D., F.A.C.P., W. Beeken, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1048_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrevious work in this laboratory has shown by a chemical photospectrometric technic that the normal 24-hr. fecal blood loss is 1.70 ± 1.2 ml., and is not influenced by diet or iron therapy. Utilizing this chemical quantitative test, it was found that thequalitativebenzidine-2HCL test on three serial stool samples gives 50% false positive and 2% false negative results. Less than 6% of false positivequalitativetests are caused by concentration of the 24-hr. stool volume or by unequal distribution of blood in the stool. Fifty per cent of patients with gastrointestinal malignancies show normal 24-hr.quantitativefecal blood... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1961Volume 54, Issue 5Page: 1048-1048KeywordsAttentionBloodBlood volumeDietHematologic testsResearch laboratories Issue Published: 1 May 1961 PDF downloadLoading ...
The Cambridge dilemma.
Authors: P Elling, H Elling, A T Olsson
Journal: Annals of the Rheumatic Diseases (1994)

The Cambridge dilemma A marked depletion of the CD8 T cell subset in the peripheral blood of patients with arteritis temporalis and polymyalgia rheu- matica (AT/PMR) has now been reported from several centres' and has been found in 80-90% of patients with active, untreated disease.6How is it, then, that the group from Addenbrooke's Hospital in Cambridge in a report on this subject in the November 1993 issue of the Annals7 concluded "that the case that CD8+ cells are lowered in patients with PMR/AT is not proven"?We would like to comment on the paper in the light of our and other recent results.In the period 1984-91 we performed temporal artery biopsy and simultaneous deter- mination of the CD8 T cell subset in 411 patients.8All patients were admitted to hospital; between 08:00 and 09:00 (before the subject undertook any exercise), blood specimens were drawn and separated within 30-60 minutes with the Ficoll-Hypaque method, followed by immediate incubation 30 -
Call and recall for cervical cytology screening.
Authors: N. Masters, H. Elmes
Journal: BMJ (1989)

The questions raised by Dr Cruickshank con- cern achieved blood pressure in individual patients.We obtained a stable reduction in diastolic blood pressure to below 90 mm Hg (treatment target) in 30 of the 41 patients receiving antihypertensive treatment.The following patients had a diastolic blood pressure >90 mm Hg: five of the nine patients with uraemia; two of three patients with myocardial infarction; and four of the 27 patients who survived.These figures indicate that seven of 14 patients who died durirr the studv had a sustained raised blood pressure despite antihypertensive treatment.
Circulation in the Three-Chambered Snake Heart
Authors: KJELL JOHANSEN
Journal: Circulation Research (1959)

Our knowledge on the physiologic evolution of the cardiovascular system is fragmentary. The reptiles and the snakes in particular represent a stage where our knowledge is especially poor. The present study deals with the circulatory dynamics of the snake heart. It may be suggested that the snake heart effectively prevents extensive mixing of arterial and venous blood. The durations of ventricular filling and contraction differ greatly from that in the mammalian heart.
Infrared Thermometry for Reading Reactions on Darkly Pigmented Skin
Authors: Herbert S. Kaufman
Journal: JAMA (1967)

Skin temperature, as measured by infrared radiation, is increased by the active hyperemia associated with a positive immediate skin test reaction in allergic individuals. An objective method for reading, recording, and quantitating such increases in temperature is possible with the use of a new instrument. This method may prove to be especially useful in identifying the degree of reaction on heavily pigmented skins, where the erythema of the reactions is difficult or impossible to see.
Mucosal adaptation to indomethacin induced gastric damage in man--studies on morphology, blood flow, and prostaglandin E2 metabolism.
Authors: C J Shorrock, W D Rees
Journal: Gut (1992)

The effect of 28 days' continuous administration of oral indomethacin on gastroduodenal morphology, gastric mucosal blood flow, and gastric mucosal prostaglandin E2 (PGE2) metabolism in man was studied to define further the mechanisms of mucosal injury induced by indomethacin. Indomethacin caused acute gastroduodenal damage in all cases, which was maximal at 24 hours of administration. With continued intake, mucosal adaptation occurs resulting in resolution of endoscopic mucosal damage. At the time of maximal mucosal damage, gastric mucosal blood flow was significantly reduced compared with values before treatment (p less than 0.001 in fundus and p less than 0.002 in antrum), with good correlation between the severity of damage and the magnitude of the reduction in blood flow (r = 0.76). Mucosal recovery was associated with a return of the blood flow to normal. PGE2 in mucosal homogenate was significantly reduced by indomethacin in both the fundus (p less than 0.01) and antrum (p less than 0.01) after 24 hours but there was no correlation between the magnitude of this reduction and the severity of mucosal damage (r = -0.34). Despite mucosal recovery by 28 days, PGE2 values remained significantly below those before treatment in both the fundus (p less than 0.01) and antrum (p less than 0.01). The PGE2 degradation capacity was not influenced by indomethacin. In conclusion, mucosal adaptation to acute damage by indomethacin occurs in man and seems independent of local PGE2 metabolism.
In vivo retroviral gene transfer into human bronchial epithelia of xenografts.
Authors: J F Engelhardt, J R Yankaskas, J M Wilson
Journal: Journal of Clinical Investigation (1992)

Cystic fibrosis (CF) is the most common lethal inherited disease in the Caucasian population with an incidence of approximately 1 in 2,500 live births. Pulmonary complications of CF, which are the most morbid aspects of the disease, are caused by primary abnormalities in epithelial cells that lead to impaired mucociliary clearance. One potential therapeutic strategy is to reconstitute expression of the CF gene in airway epithelia by somatic gene transfer. To this end, we have developed an animal model of the human airway using bronchial xenografts and have tested the efficiency of in vivo retroviral gene transfer. Using the LacZ reporter gene, we find the efficiency of in vivo retroviral gene transfer to be dramatically dependent on the regenerative and mitotic state of the epithelium. Within an undifferentiated regenerating epithelium in which 40% of nuclei labeled with BrdU, 5-10% retroviral gene transfer was obtained. In contrast, no gene transfer was noted in a fully differentiated epithelium in which 1% of nuclei labeled with BrdU. These findings suggest that retroviral mediated gene transfer to the airway in vivo may be feasible if the proper regenerative state can be induced.
Purpura, Arthralgia, and IgM-IgG Cryoglobulinemia with Rheumatoid Factor Activity
Authors: DAVID A. MATHISON
Journal: Annals of Internal Medicine (1971)

A 50-year-old man was seen for evaluation of urticaria, purpura, and recurrent leg ulcers of 5 years' duration. He was found to have a primary mixed IgM-IgG cryoglobulinemia with rheumatoid factor activity and histologic evidence of cutaneous vasculitis and glomerulonephritis. He received cyclophosphamide for over 18 months with improvement in his clinical course and reduction of the serum cryoglobulin. After splenectomy for hypersplenism the serum cryoglobulin fell precipitously and the clinical course stabilized. The nature and biologic activity of the cryoglobulin, possible pathophysiologic mechanisms operative in the disease, and approaches to therapy are discussed.
Treatment of Lymphedema
Authors: Stephen R. Lewis
Journal: JAMA (1979)

To the Editor.—  In regard to the question asked in Management of Chronic Lymphedema in a Young Man by L. George Hershey, DO (241:1625, 1979), I was distressed with the final answer by David I. Abramson, MD.  There is adequate evidence that it takes pressures of between 20 to 30 mm Hg to keep lymphedema under control, and this is similar to work done in the treatment of hypertrophic burn scars. With hypoplastic lymphatic channels, one can anticipate, unless optimum pressure is maintained, that there will be a gradual increase in the size of the areas involved with lymphedema. To the best of my knowledge, there is no evidence that furosemide (Lasix) really helps in the management of secondary lymphedema as it relates to aplastic or hypoplastic lymphatic channels or with destruction of the continuity of lymphatic channels.  Basically, secondary lymphedema, which I presume this case to be, indicates first the
Detection of Cerebral Hypoperfusion During Trial Carotid Occlusion With Reversal Following Extracranial-lntracranial Bypass Prior to Permanent Occlusion
Authors: BRANDY S. WALKER, DANA MATHEWS, HUNT BATJER, BETH C. ALLEN, PHILLIP D. PURDY
Journal: Clinical Nuclear Medicine (1994)

The authors describe a patient with a large intracavernous aneurysm of the right internal carotid artery and a marked decrease in focal brain blood flow induced by temporary carotid balloon occlusion. The patient subsequently underwent a superficial temporal to middle cerebral artery bypass followed by successful carotid occlusion using detachable balloons placed proximal to the aneurysm. Postoperative rCBF demonstrated normal perfusion in the region of the right internal carotid artery distribution as well as normalization of perfusion to a previous area of baseline perfusion abnormality. Cerebral brain blood flow imaging was useful in the initial evaluation as well as the management of this patient.
Study finds no link between hospital cleanliness and MRSA
Authors: Roger Dobson
Journal: BMJ (2006)

New research has failed to find a link between hospital cleanliness ratings and rates of methicillin resistant Staphylococcus aureus (MRSA).

Although the Department of Health has emphasised the importance of hospital cleanliness in reducing MRSA, researchers were unable to establish a consistent link in the data they analysed ( Journal of Hospital Infection 2006;64:184-6).

“The authors believe, and the data support this belief, that there is no direct link between hospital …
Employer-Sponsored Insurance — Riding the Health Care Tiger
Authors: David Blumenthal
Journal: New England Journal of Medicine (2006)

The rising cost of health care has become a serious problem for employers who provide health insurance to their workers. In this second part of a two-part Health Policy Report, Blumenthal discusses an array of strategies that employers and health-insurance companies are adopting to reduce health care costs and improve the efficiency of the nation's health care system.
Researchers thrash out guidelines for working with partners
Authors: C. Dyer
Journal: BMJ (2013)

Researchers from around the world gathered in Montreal this week to try to agree a statement to ensure the integrity of scientific research in cross boundary collaborations.

The draft Montreal statement, which was keenly debated at the Third World Conference on Research Integrity taking place between 5 and 8 May, is intended to tackle the challenges arising in the growing number of collaborations across institutions and national borders.

It builds on the Singapore statement on research integrity, which set out 14 …
Long-term Follow-up of the Physiologic Abnormalities and Fundus Changes in Fundus Albipunctatus
Authors: Michael F. Marmor
Journal: Ophthalmology (1990)

<h2>Abstract</h2> Fundus albipunctatus (FA) is considered to be a congenital stationary night-blinding disorder, but there has been no electrophysiologic or photographic documentation of long stability or change. This documentation is presented for two cases followed for 13 to 14 years. The physiologic (functional) deficits appeared to be stable, in support of the concept that FA is not a progressive dystrophy. However, the fundus lesions evolved in appearance from flecks in childhood to relatively permanent punctate dots that increase in number over the years.
Pemphigus vulgaris and myasthenia gravis
Authors: J.M. VETTERS, N.K. SAIKIA, JANE WOOD, J.A. SIMPSON
Journal: British Journal of Dermatology (1973)

Journal Article Pemphigus vulgaris and myasthenia gravis Get access J.M. VETTERS, J.M. VETTERS University departments of Dermatology and Pathology, Western Infirmary, Glasgow and the Institute for Neurological Sciences, Glasgow Search for other works by this author on: Oxford Academic Google Scholar N.K. SAIKIA, N.K. SAIKIA University departments of Dermatology and Pathology, Western Infirmary, Glasgow and the Institute for Neurological Sciences, Glasgow Search for other works by this author on: Oxford Academic Google Scholar JANE WOOD, JANE WOOD University departments of Dermatology and Pathology, Western Infirmary, Glasgow and the Institute for Neurological Sciences, Glasgow Search for other works by this author on: Oxford Academic Google Scholar J.A. SIMPSON J.A. SIMPSON University departments of Dermatology and Pathology, Western Infirmary, Glasgow and the Institute for Neurological Sciences, Glasgow Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 88, Issue 5, 1 May 1973, Pages 437–441, https://doi.org/10.1111/j.1365-2133.1973.tb15446.x Published: 01 May 1973 Article history Accepted: 11 October 1972 Published: 01 May 1973