tbuckley/cabot-search huggingface dataset:
Acupuncture for Chronic Mechanical Neck Pain
Authors: Peter J. White, George Lewith
Journal: Annals of Internal Medicine (2005)

Letters17 May 2005Acupuncture for Chronic Mechanical Neck PainPeter J. White, PhD, BSc and George Lewith, DMPeter J. White, PhD, BScFrom the University of Southampton, Southampton SO16 5ST, United Kingdom.Search for more papers by this author and George Lewith, DMFrom the University of Southampton, Southampton SO16 5ST, United Kingdom.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-10-200505170-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We would like to reply both to Dr. Ernst's letter and to the editorial by Deyo that accompanied our manuscript (2).We agree, as we pointed out in our paper, that the provision of acupuncture by only 1 practitioner was a weakness of our study and might have implications for generalizability. However, both Dr. Ernst and Dr. Deyo make the same error in interpreting our results and conclusions, that of confusing effectiveness and efficacy. We believe that this is an important distinction.From our results, it can be clearly seen that acupuncture did indeed have a large effect. ...References1. Deyo RA. Treatments for back pain: can we get past trivial effects? [Editorial]. Ann Intern Med. 2004;141:957-8. [PMID: 15611493] LinkGoogle Scholar2. Lewith GT, Hyland ME, Shaw S. Do attitudes toward and beliefs about complementary medicine affect treatment outcomes? Am J Public Health. 2002;92:1604-6. [PMID: 12356605] CrossrefMedlineGoogle Scholar3. White PJ. Attitude and outcome: is there a link in complementary medicine? [Letter]. Am J Public Health. 2003;93:1038. [PMID: 12835174] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From the University of Southampton, Southampton SO16 5ST, United Kingdom.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAcupuncture versus Placebo for the Treatment of Chronic Mechanical Neck Pain Peter White , George Lewith , Phil Prescott , and Joy Conway Treatments for Back Pain: Can We Get Past Trivial Effects? Richard A. Deyo Acupuncture for Chronic Mechanical Neck Pain Edzard Ernst Metrics 17 May 2005Volume 142, Issue 10Page: 873-874KeywordsAcupunctureClinical trialsComplementary and alternative medicineConflicts of interestDrugsMotivationPatients ePublished: 17 May 2005 Issue Published: 17 May 2005 CopyrightCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Breast Cancer Risk From Diet, Tobacco, and Alcohol-Reply
Authors: Walter C. Willett
Journal: JAMA (1993)

<h3>In Reply.</h3> —We cannot understand why Dr Prentice wishes only to dichotomize fat intake into below and above the median, which minimizes the contrast in intake. When the highest categories of fat intake (quintiles except in the study by Howe et al) are compared with the lowest categories, the relative risks were 0.90 in our study (1439 cases), 1.30 in the study by Howe et al (519 cases), and 1.13 in the study by Kushi et al (468 cases). Moreover, two additional large prospective studies have been published subsequent to ours; the corresponding relative risks were 1.08 in the study by van den Brandt et al<sup>1</sup>with 471 cases and 0.99 in the study by Graham et al<sup>2</sup>with 359 cases. Thus, the prospective studies clearly provide an overall association that is very close to the null value of 1.0 and substantially different from the pooled results from
Our Cancer Year
Authors: I. Williams
Journal: BMJ (2010)

Harvey Pekar, jazz critic and author of the autobiographical comic series American Splendor (the basis of a 2003 film of the same name), died in July this year. He had prostate cancer. A file clerk in a Cleveland hospital until he retired in 2001, Pekar had documented the day to day idiosyncrasies of his life and work since 1976 in the comic series he published and distributed himself. He was one of the first writers to think that everyday life could provide the basis for comic book stories, and he hired various cartoonists, notably Robert Crumb and Joe …
HIV testing in patients with end stage renal disease.
Authors: A Stevens, J Little, S Kerr, P Kilbane, C Doherty
Journal: BMJ (1990)

One hundred and twenty eight British and Irish nephrologists were questioned about their policy for HIV testing of patients with end stage renal failure being considered for renal replacement therapy. A total of 101 (79%) replied. In the case of candidates for dialysis roughly one third of respondents tested only people they considered at risk of infection with HIV and nearly one fifth considered testing unnecessary. In the case of candidates for transplantation routine HIV testing was carried out by 68 of 100 nephrologists; 22 tested only patients "at risk" and 10 did not test. A positive HIV test result was considered by most but not all respondents (63/86) to exclude patients from transplantation. Twenty four of 88 nephrologists considered that HIV positivity should exclude patients from haemodialysis, but only seven of 87 would exclude such patients from peritoneal dialysis. Similar attitudes pertained for patients with end stage renal failure who refused HIV testing. Testing with the patient9s knowledge and consent was the policy of two thirds of nephrologists, but a patient9s signature was obtained by only 24 of 88. There should be a consensus on practice for HIV testing of patients with end stage renal failure.
Large Doses of Radioiodine in the Treatment of Thyrotoxicosis
Authors: S. H. Ingbar
Journal: New England Journal of Medicine (1968)

Indications for the use of radioactive iodine in the treatment of hyperthyroidism, the proper treatment schedule and the attendant complications currently are undergoing widespread re-evaluation. This has been prompted in the main by the recognition that delayed post-radiation hypothyroidism is considerably more frequent than previously thought and is, in the view of many, too frequent to be tolerated within the entire population of patients to be treated for hyperthyroidism. Attention has been focused, therefore, on methods that would exploit the advantages of 131I therapy while decreasing the risk of hypothyroidism, mainly by reducing the dose of 131I.1 , 2 Such methods, however, . . .
Heterogeneity of hypogammaglobulinemia
Authors: Michael E. Miller
Journal: American Journal of Hematology (1980)

Abstract In 1952, Ogden Bruton described the first patient with recurrent infections and hypogammaglobulinemia [1]. For many years thereafter, hypogammaglobulinemia (or agammaglobulinemia) was believed to result from a deficiency (or absence) of the antibody‐producing cells, or “B” cell line of the lymphoid system. With increased recognition of functional subpopulations of the lymphoid system, however, it has become apparent that a variety of mechanisms may result in the phenotype of hypogammaglobulinemia. Since these entities may be clinically indistinguishable, it is important to understand the various categories of disease which may be involved. In this concise review, these areas are briefly summarized, More complete reviews of the subject (including acquired forms of immunodeficiency) are available [2, 3].
Acute psychosis caused by co-amoxiclav
Authors: C. L Bell, B. Watson, W S. Waring
Journal: BMJ (2008)

Co-amoxiclav is a fixed dose combination of amoxicillin and clavulanate that offers antibacterial activity against some strains that produce β lactamase. Recognised adverse effects include exfoliative dermatitis, deranged liver biochemistry, and anaphylaxis.1 We report the occurrence of acute psychosis after giving co-amoxiclav, with a strong temporal relationship and recurrence after drug rechallenge.

A 55 year old woman was prescribed oral co-amoxiclav for suspected pneumonia. Within two hours …
5-HYDROXYTRYPTAMINE AND HISTAMINE AS MEDIATORS OF THE VASCULAR INJURY PRODUCED BY AGENTS WHICH DAMAGE MAST CELLS IN RATS
Authors: Donald A. Rowley, Earl P. Benditt
Journal: The Journal of Experimental Medicine (1956)

Each of the four agents, ovomucoid, dextran, 48/80, and testis extract, when injected beneath the skin of the dorsa of the paws of rats produces a local vascular injury characterized by a protein-rich edema. Each agent also produces damage to mast cells. Either 5-hydroxytryptamine or histamine produces a response similar in the gross to that elicited by the agents which damage mast cells; however, neither of these two agents produces mast cell damage. On a weight basis 5-hydroxytryptamine is a much more potent edema-producing agent than histamine. The edema-producing action of 5-hydroxytryptamine can be differentiated from the similar action of histamine by the use of specific antagonists; dibenamine is a 5-hydroxytryptamine antagonist and pyrilamine a histamine antagonist. The edema produced by the mast cell-damaging agents is partially inhibited by dibenamine but is not diminished by pyrilamine. It is completely inhibited by treatment of rats with both drugs. The drugs which inhibit edema do not prevent mast cell damage by ovomucoid, dextran, 48/80, or testis extract. The observations are consistent with the hypothesis that agents which damage mast cells, "release" both 5-hydroxytryptamine and histamine and that in the rat the edema associated with mast cell damage is mediated largely by 5-hydroxytryptamine.
Multi-Institutional Study of Implantable Defibrillator Lead Performance in Children and Young Adults
Authors: Joseph Atallah, Christopher C. Erickson, Frank Cecchin, Anne M. Dubin, Ian H. Law, Mitchell I. Cohen, Martin J. LaPage, Bryan C. Cannon, Terrence U.H. Chun, Vicki Freedenberg, Marcin Gierdalski, Charles I. Berul
Journal: Circulation (2013)

Implantable cardioverter-defibrillator (ICD) therapy in children and congenital heart disease patients is hampered by poor long-term lead survival. Lead extraction is technically difficult and carries substantial morbidity. We sought to determine the outcomes of ICD leads in pediatric and congenital heart disease patients.The Pediatric Lead Extractability and Survival Evaluation (PLEASE) is a 24-center international registry. Pediatric and congenital heart disease patients with ICD lead implantations from 2005 to 2010 were eligible. Study subjects comprised 878 ICD patients (44% congenital heart disease). Mean±SD age at implantation was 18.6±9.8 years. Of the 965 total leads, 54% were thin (≤7F), of which 57% were Fidelis, and 23% were coated with expanded polytetrafluoroethylene. There were 139 ICD lead failures (14%) in 132 patients (15%) at a mean lead age of 2.0±1.4 years, causing shocks in 53 patients (40%). Independent predictors of lead failure included younger implantation age and Fidelis leads. Actuarial analysis showed an incremental risk of lead failure with younger age at implantation: <8 years compared with >18 years (P=0.015). The actuarial yearly failure rate was 2.3% for non-Fidelis and 9.1% for Fidelis leads. Extraction was performed on 143 leads (80% thin, 7% expanded polytetrafluoroethylene coated), with lead age as the only independent predictor for advanced extraction techniques. There were 6 major extraction complications (4%) but no procedural mortality.This study demonstrates that ICD leads in children and congenital heart disease patients have an age-related suboptimal performance, further compounded by a high failure rate of Fidelis leads. Advanced extraction techniques were common and correlated with older lead age.URL: http://www.clinicaltrials.gov. Unique identifier: NCT00335036.
Take Two Aspirin and See Me in the Macrocosm
Authors: None Jiminy
Journal: JAMA (1980)

WHILE looking over the shoulder of my seatmate on a crowded bus this morning, I noticed an article in the Chicago Sun-Times . Elliot M. Estes, president of General Motors Corp, was quoted as saying that the current economic problems we are experiencing in this country are just a hiccup in the long-term health of the economy. It should be mentioned, I suppose, that this speech was made in Sao Paulo, Brazil. Presumably, Mr Estes chooses to be out of the country while it is hiccuping.  I was delighted to hear our country's problems described in these terms, since, as a physician, this is a form in which I can address them. It is well known that a hiccup, or more formally singultus, is A diaphragmatic spasm causing a sudden inhalation which is interrupted by the spasmodic closure of the glottis, producing a noise. That there is an analogy between our
Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis.
Authors: K Miyake, I L Weissman, J S Greenberger, P W Kincade
Journal: The Journal of Experimental Medicine (1991)

Adhesion molecules are probably required for retention of maturing lymphocyte precursors in bone marrow, where they closely interact with and are dependent on stromal cells. Lymphomyeloid cell lines avidly adhere to cloned stromal cell lines in culture and screening pairs of these resulted in a selection strategy for a new monoclonal antibody to a leukocyte adhesion molecule. Immunoprecipitation analyses and comparison to a previously described antibody showed that it recognizes the alpha 4 chain of the integrin, VLA-4. This antibody totally inhibited lymphopoiesis and retarded myelopoiesis in long-term bone marrow cultures. A similar selection strategy resulted in two additional antibodies which define a single 100-kD species on stromal cells. This stromal cell adhesion molecule is a potential counter-receptor/ligand for VLA-4 on murine lympho-myeloid cells. Our findings suggest a new role for VLA-4 in lymphoid progenitor-microenvironment interactions. Recognition molecules that function in cell migration and inflammation in peripheral tissues may be important for steady-state lymphopoiesis within bone marrow.
A Guide to the Problem of Photosensitivity
Authors: James Kalivas
Journal: JAMA (1969)

Cutaneous eruptions more or less confined to light-exposed areas are not uncommon. Despite numerous exhaustive reviews<sup>1-7</sup>published in recent years, it is difficult for most practitioners to acquire a real diagnostic expertise in this field. Too often, the only characteristic feature in any given case is the distribution of the lesions. Hopefully, the following schemes will provide some new perspectives and helpful insights by plotting differentiating features as attributes against the<i>primary</i>light-sensitive dermatoses; by commenting on the more important (or more interesting) photosensitizing<i>drugs</i>and<i>contactants</i>; and, finally, by indicating which laboratory tests are likely to be of specific diagnostic value when the history and physical findings are inconclusive (as, for example, in protoporphyria). I. The physical examination and history B. Extrinsic photosensitivity 1. Internal agents<sup>*</sup>(drug-induced) Sulfonamides†—uncommon with modern analogues, in contrast to the older drug, sulfanilamide Sulfonylureas† Thiazides,† quinethazone†—may have<i>only</i>pruritus in sun-exposed sites
Diabetes in Kentucky
Authors: Steven B Leichter, Carlos Hernandez, Ansella Fisher, Peggy Collins, Anita Courtney
Journal: Diabetes Care (1982)

A state diabetes commission and university diabetes program in Kentucky jointly studied the social and economic impact of diabetes mellitus and its complications on the Commonwealth. This investigation revealed that diabetes was a more serious public health problem than previously supposed. Active, diagnosed diabetes afflicts 4.4% Kentucky's population. Less severe clinical and “borderline” forms of diabetes affect an additional 2.4%. Diabetes is especially prevalent in Appalachian regions and in rural, Western Kentucky. In contrast, its prevalence in Lexington, the second-largest city, is 2.7%, similar to the current, estimated national prevalence. Diabetes is the leading cause of hospitalization by disease, and costs approximately $98,800,000 to $135,000,000. Previous estimates of these social and economic losses were lower, partly because they failed to account for the impact of diabetic complications. An average of 5.23% of all hospitalized Kentuckians have diabetes. Specific services for diabetes care, including organized patient education programs, social or psychological counseling, and preventive foot care, were offered by less than 8% of accredited Kentucky hospitals. This study demonstrates the disparity between need and available services, particularly preventive services, for diabetes care in the health care system.
D polymorphism of the angiotensin converting enzyme gene is strongly associated with the development of physiological left ventricular hypertrophy
Authors: Hugh Montgomery, Peter Clarkson, Clare Dollery, Krishna Prasad, Maria-Angela Losi, Deborah Statters, Mick Jubb, Jean McEwan, Stephen Humphries, William McKenna
Journal: Journal of the American College of Cardiology (1996)
Effectiveness of the postcoital test: randomised controlled trial
Authors: S G. Oei, F. M Helmerhorst, K. W M Bloemenkamp, F. A M Hollants, D. E M Meerpoel, M. J N C Keirse
Journal: BMJ (1998)

<h3>Abstract</h3> <b>Objectives</b> : To investigate the impact of the postcoital test on the pregnancy rate among subfertile couples and on the number of other diagnostic tests and treatments. <b>Design</b> : Randomised controlled study. <b>Setting</b> : A university and two non-university teaching hospitals in the Netherlands. <b>Subjects</b> : New couples at infertility clinics, 1 March 1993 to 1 October 1995; randomisation to an intervention group (series of infertility investigations that include the postcoital test) or to a control group (series excluding the test). <b>Main outcome measure</b> : Cumulative pregnancy rate. <b>Results</b> : Of 736 consecutive new couples, 444 fulfilled the inclusion criteria and consented to participate (intervention group, 227; control group, 217). Treatment was given more often in the intervention group than in the control group (54% v 41%; difference 13% (95% confidence interval 4% to 22%)). Yet cumulative pregnancy rates at 24 months in the intervention group (49% (42% to 55%)) and the control group (48% (42% to 55%)) were closely similar (difference 1% (−9.0% to 9.0%)). <b>Conclusion</b> : Routine use of the postcoital test in infertility investigations leads to more tests and treatments but has no significant effect on the pregnancy rate.
Legislating Safety — How Far Should We Go?
Authors: Daniel Callahan
Journal: New England Journal of Medicine (1989)

Not many months ago, I gave my adult daughter a bicycle as a birthday present. After buying her a tire pump and a small tool kit, I wondered whether I should also buy her a helmet, the least expensive of which cost about $45. I complained about the price, but in the end I bought the helmet and gently but firmly exhorted my daughter to use it. She has since reported that she rarely, if ever, does.In this issue of the Journal, Thompson and his colleagues present solid evidence in their study of bicycle safety helmets to support . . .
Healing Arts in Dialogue: Medicine and Literature
Authors: Norman Cousins
Journal: JAMA (1983)

This book seeks to convey the spirit and substance of a series of discussions on the general subject of literature and medicine. The discussants, for the most part, are persons who have a foot in each camp. The exchanges, therefore, are not primarily the reflections of physicians seeking to explicate their science and their purposes to writers, or of writers seeking to satisfy the curiosity of scientists about persons who live comfortably with unfinished manuscripts and symphonies. The dialogues consist largely of philosophical excursions by ten persons (one dropped out early in the series) with credentials in medicine or literature or both who are trying to understand their own commitments and preoccupations. As such, this book is not so much a consistent development of a theme that implies some degree of contrasting values as it is a grand array of ideas and intellectual thrusts that lose none of their appeal
Health needs of women who have sex with women
Authors: Clare Hughes, Amy Evans
Journal: BMJ (2004)

Editor—We thank everyone who contributed to the rapid response debate on bmj.com.1 Many of the responses related to homophobia in medicine. The editorial was designed to raise awareness of the healthcare needs of women who have sex with women rather than to stimulate a debate about the morality of homosexuality.

Varney's comments on accessibility and appropriateness of care provided by an informed clinical workforce are apposite.

Malterud expressed justified concern about the appropriateness of the conclusions we drew using the restricted epidemiological data available. We agree that epidemiological data concerning sexuality and health outcomes are difficult to gather and interpret.

We are pleased Frisch brought attention to a Danish study that was not published at the time of our submission and is the only population based study in this area listed in Medline. It shows that women who have sex with women are not at higher risk of cancers than heterosexual women.2 We note the study's limitations in monitoring a self selected homosexual population in registered partnerships only, of relatively young age, and with short follow up. We also note the small numbers of incident cancers with which the statistical analyses were made and think it would be dangerous to draw unequivocal conclusions from a single paper.

The literature available presents evidence that women who have sex with women have increased risk factors for a variety of conditions. We look forward to the publication of further direct evidence that assesses the population impact of these risks and helps improve the standard of care for this important minority group.
Update on Metastatic Basal Cell Carcinoma: A Summary of Published Cases From 1981 Through 2011
Authors: Ashley Wysong, Sumaira Z. Aasi, Jean Y. Tang
Journal: JAMA Dermatology (2013)

La urticaria crónica (UC), es una variante común de la urticaria que se define como un síndrome reactivo de la piel y mucosas caracterizado por la presencia de placas eritematosas, habones o ronchas edematosas y pruriginosas que se prolonga durante más de seis semanas.La etiología de la UC no es muy clara en la mayoría de los casos, multitud de causas se han implicado.La patogenia es compleja.El conocimiento y estudio de cada uno de los factores celulares y solubles, su interacción dinámica, vías efectoras y trama de citoquinas conducirá al logro de una terapéutica efectiva y racional de la urticaria crónica
Early redistribution of thallium-201 after temporary ischemia.
Authors: J S Schwartz, R Ponto, P Carlyle, L Forstrom, J N Cohn
Journal: Circulation (1978)

To define the time course of redistribution of thallium-201 (201Tl), ischemia was induced in seven pigs by temporary occlusion of the circumflex coronary artery. After 1 1/2 min of occlusion 201Tl and labeled microspheres were injected into the left atrium. Flow was re-established 4 min after occlusion. Prior to reflow, the relative activities of 201Tl and microspheres in the ischemic area were similar, but as early as 5 min after reflow the relative 201Tl activity was considerably higher than the relative microsphere activity and from 15 to 105 min after reflow, relative 201Tl activity (averabe 69% of that in normal myocardium) continued to be higher than relative microsphere activity (average 6% of normal). Myocardial arteriovenous differences for 201Tl were followed sequentially after 201Tl injection in normal dogs and in dogs with temporary coronary occlusions. The results suggested both loss of 201Tl from normal myocardium beginning 10 min after 201Tl injection and increased extraction of 201Tl from the blood pool immediately after release of a transient occlusion. Redistribution of 201Tl therefore begins very soon after relief of myocardial ischemia and even a short delay in initiating myocardial imaging may decrease the sensitivity of the technique for detecting transient ischemia.