NALORPHINE HYDROCHLORIDE, N.N.R. ("NALLINE HYDROCHLORIDE")
Authors: RAYMOND M. BURGISON
Journal: Annals of Internal Medicine (1954)

Editorial1 January 1954NALORPHINE HYDROCHLORIDE, N.N.R. ("NALLINE HYDROCHLORIDE")RAYMOND M. BURGISONRAYMOND M. BURGISONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-1-183 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough morphine has been one of the most important drugs in the physician's armamentarium for many years, its serious disadvantages have always been recognized. Along with the dangers inherent in overdosage of the drug, serious side effects have limited its usefulness—depression of the respiration, slowing and weakness of the pulse, constipation, nausea and vomiting, excitation in some individuals and the ever present danger of addiction.Because of these disadvantages and the virtual indispensability of morphine for the relief of severe pain, many attempts have been made to find substitutes possessing the analgesic properties of morphine but devoid of its serious...1 McCawleyHartMarsh ELERDF: Preparation of N-allylnormorphine, J. Am. Chem. Soc. 63: 314 (Jan.) 1941. CrossrefGoogle Scholar2 Unna K: Antagonistic effect of N-allylnormorphine upon morphine, J. Pharmacol. and Exper. Therap. 79: 27-31 (Sept.) 1943. Google Scholar3 HartMcCawley EREL: Pharmacology of N-allylnormorphine as compared to morphine, ibid. 82: 339-348 (Dec.) 1944. Google Scholar4a SmithLehmanGilfillan CCEGJL: Antagonistic action of N-allylnormorphine upon the analgetic and toxic effects of morphine, methadone derivatives and Isonipecaine, Fed. Proc. 10: 335-336 (March) 1951. Google Scholar4b HugginsGlassBrown RAWGAR: Protective action of N-allylnormorphine against respiratory depression produced by some compounds related to morphine, Proc. Soc. Exper. Biol. and Med. 75: 540-541 (Nov.) 1950. CrossrefMedlineGoogle Scholar4c EckenhoffElderKing JEJDBD: The effect of N-allylnormorphine in treatment of opiate overdose, Am. J. M. Sc. 222: 115 (July) 1951. Google Scholar4d EckenhoffElderKing JEJDBD: N-allylnormorphine in the treatment of morphine or Demerol narcosis, Am. J. M. Sc. 223: 191-197 (Feb.) 1952. CrossrefMedlineGoogle Scholar4e EckenhoffHoffmanDripps JEGLRD: N-allylnormorphine: an antagonist to the opiates, Anesthesiology 13: 242-251 (May) 1952. CrossrefMedlineGoogle Scholar4f ChaseBoydAndrews HFRSPM: N-allylnormorphine in treatment of dihydromorphinone and methorphian overdosage: report of a case, J. A. M. A. 150: 1103-1104 (Nov. 15) 1952. CrossrefMedlineGoogle Scholar4g BornsteinYorburgJohnston MLB: N-allylnormorphine in treatment of methorphinan (Dromoran) hydrobromide poisoning, J. A. M. A. 151: 908-910 (March 14) 1953. CrossrefMedlineGoogle Scholar4h DominoPelikanTraut EFEWEF: Nalorphine (Nalline) antagonism to racemorphan (Dromoran) intoxication, J. A. M. A. 153: 26-27 (Sept. 5) 1953. CrossrefMedlineGoogle Scholar4i Wikler A: Effects of large doses of N-allylnormorphine on man, Fed. Proc. 10: 345 (March) 1951. Google Scholar5 EckenhoffHoffmanFunderburg JEGLLW: N-allylnormorphine: an antagonist to neonatal narcosis produced by parturient sedation. Presented before A. M. A. Meeting, Chicago, June, 1952. Google Scholar6 FraserWiklerEisenmanIsbell HFAAJH: Use of N-allylnormorphine in the treatment of methadone poisoning in man: report of two cases, J. A. M. A. 148: 1205-1207 (April 5) 1952. CrossrefMedlineGoogle Scholar7 Adriani J: Combatting narcotic-induced respiratory depression in surgery, Merck Report 62: 27-29 (April) 1953. MedlineGoogle Scholar8 Isbell H: Report to the Council. "What to do with a drug addict," J. A. M. A. 149: 1220-1223 (July 26) 1952. MedlineGoogle Scholar9 Isbell H: Nalline, a specific narcotic antagonist, Merck Report 62: 23-26 (April) 1953. MedlineGoogle Scholar10 WiklerFraserIsbell AHFH: Effects of single doses and precipitation of acute "abstinence syndromes" during addiction to morphine, methadone or heroin in man (post addicts), J. Pharmacol. and Exper. Therap. 109: 8-20 (Sept.) 1953. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RAYMOND M. BURGISON PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCare of the Patient With Chronic Pulmonary Disease 1 January 1954Volume 40, Issue 1Page: 183-186KeywordsAnalgesicsConstipationDrug addictionDrugsHeart rateMorphineNauseaOpioid addictionRespirationVomiting ePublished: 1 December 2008 Issue Published: 1 January 1954 PDF downloadLoading ...