tbuckley/cabot-search huggingface dataset:
The treatment of resistant mosaic plantar warts with aggressive cryotherapy under general anaesthetic
Authors: M. RADEMAKER, R.H. MEYRICK THOMAS, D.D. MUNRO
Journal: British Journal of Dermatology (1987)

Twelve patients with treatment-resistant mosaic plantar warts were treated with aggressive cryotherapy under a general anaesthetic. Seven patients (58%) had complete cure, two patients (16%) experienced substantial but incomplete clearing of their warts and the remaining three patients (25%) had no improvement. The procedure was well tolerated and post cryotherapy pain was acceptable to the patients.
Relation between heart rate variability and spontaneous and induced ventricular arrhythmias in patients with coronary artery disease
Authors: Juhani O. Valkama, Heikki V. Huikuri, Juhani Koistinen, Sinikka Yli-Mäyry, K.E. Juhani Airaksinen, Robert J. Myerburg
Journal: Journal of the American College of Cardiology (1995)

Objectives. The aim of this study was to determine the relation between autonomic control of heart rate and the spontaneous occurrence and inducibility of ventricular arrhythmias in patients with coronary artery disease. Background. Low heart rate variability increases the risk of arrhythmic events. It is not known whether impaired autonomic heart rate control reflects alterations in functional factors that contribute to the initiation of spontaneous arrhythmias or whether it is the consequence of an anatomic substrate for reentrant tachyarrhythmias. Methods. Fifty-four patients with coronary artery disease with a history of sustained ventricular tachycardia (n = 25) or cardiac arrest (n = 29) were studied by 24-h ambulatory electrocardiographic recording and by programmed electrical stimulation. Heart rate variability was compared among the patients with and without spontaneous ventricular arrhythmias and with and without inducibility of sustained ventricular tachyarrhythmias. Results. Eight patients had a total of 21 episodes of sustained ventricular tachycardia on Holter recordings. Standard deviation of RR intervals and low frequency and very low frequency components of heart rate variability were significantly blunted in patients with sustained ventricular tachycardias compared with those without repetitive ventricular ectopic activity (p < 0.05, p < 0.01 and p < 0.05, respectively). However, no significant alterations were observed in heart rate variability before the onset of 21 episodes of sustained ventricular tachycardia. Heart rate variability did not differ between the patients with or without nonsustained episodes of ventricular tachycardia. In patients with frequent ventricular ectopic activity, low frequency and very low frequency power components were significantly blunted compared with those with infrequent ventricular ectopic activity (p < 0.01 and p < 0.001, respectively). Heart rate variability did not differ significantly between the patients with and without inducible sustained ventricular tachyarrhythmias. Conclusions. Impaired very low and low frequency oscillation of heart rate reflects susceptibility to the spontaneous occurrence of ventricular arrhythmias but may not reflect the instantaneous triggers for life-threatening arrhythmias or a specific marker of the arrhythmic substrate for ventricular tachyarrhythmias.
Married life uncovered
Authors: J. O. Drife
Journal: BMJ (2003)

Mr and Mrs: The Wrights BBC 2, 28 May at 9 50 pm Rating: ![Graphic][1]</img>![Graphic][2]</img> On the front of last week's TV Times were a handsome doctor and a pretty nurse complete with old fashioned uniform and starched cap. They were from a prime time series set in a nostalgic era when doctors and nurses fell in love, married, and lived happily ever after. They were, of course, fictional. On Wednesday evening a real, contemporary doctor and nurse, married for seven years, appeared in the first of four “fly on the wall” … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif
Combination of a Novel Growth Hormone Releasing Hormone Antagonist JMR 132 and Tamoxifen Enhances the Inhibitory Effects on Growth of ZR 75 and T47D Estrogen Dependent Human Breast Cancer Cells In Vitro and In Vivo.
Authors: S. Buchholz, F. Koester, A. Schally, A. Krishan, A. Papadia, O. Ortmann, S. Seitz
Journal: Cancer Research (2009)

Abstract Background: Tamoxifen is the oldest selective estrogen receptor modulator (SERM) developed to antagonize the estrogen receptor function on human breast cancer cells. JMR 132 is a novel GHRH Antagonist proven to be potent inhibitor of tumor growth in estrogen receptor negative human breast cancer cell lines. A combination of both substances could induce a more potent growth inhibition, as compared to the single drugs.Methods: To determine inhibitory effects of the GHRH antagonist JMR 132 and Tamoxifen alone and in combination, estrogen receptor positive cell lines ZR 75 and T 47D were incubated with substances at concentrations of 2.5µM, 5µM and 10µM. The cell viability after a period of 72 h was measured by MTT assay. To assess if the treatment arrested cell growth at a specific phase of the cell cycle or simply caused cell death, we performed a flow cytometric DNA cell cycle analysis on ZR 75 cells exposed to JMR 132, Tamoxifen and their combination. In an in vivo model, the cell line ZR 75 was xenografted subcutaneously into nude mice. Treatment groups were control, JMR 132 at a dose of 10µM, Tamoxifen at a dose of 100µgr per mouse q3 per week and the combination of both substances. All given for a period of 4 weeks.Results: In vitro 1o µM JMR 132 and Tamoxifen significantly decreased the proliferation of the ZR 75 and T47D cell lines, as compared to controls (p&amp;lt; 0.05). The combination of 1o µM inhibited the growth of ZR 75 was significantly by 14%, as compared to JMR 132 alone. The combination also significantly suppressed the growth of T47D by 14% and 22% respectively, as compared to Tamoxifen and JMR 132. In in vivo treatment with the combination of JMR 132 and Tamoxifen induced a significant inhibition of tumor growth of ZR 75 xenografts after 14 days compared to the single agents groups and inhibition remained significant until the end of the study on day 28. The flow cytometric DNA cell cycle analysis revealed a cell cycle arrest in the S Phase which led to apoptosis of the cells.Conclusion: Treatment of ZR 75 and T47D estrogen receptor positive human breast cancer lines with GHRH antagonist JMR 132 and its combination with Tamoxifen induced potent inhibitory effects in vitro and in vivo and led to subsequent cell death. Further studies are being conducted to elucidate the mechanisms of action of these effects. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5073.
RISK STRATIFICATION OF CARDIAC SARCOIDOSIS WITH PRESERVED LEFT VENTRICULAR EJECTION FRACTION USING CARDIOVASCULAR MAGNETIC RESONANCE
Authors: Gillian Murtagh, Karima Addetia, Amit V. Patel, Luke Laffin, John Beshai, Joshua Moss, Victor Mor-Avi, Roberto Lang, Amit Patel
Journal: Journal of the American College of Cardiology (2014)
Points from letters: Barbiturates on the way out
Authors: S V Humphries
Journal: BMJ (1975)

October, p 25) is not alone.At the inception of the NHS in 1948 I was an assistant in general practice and lived above the surgery in a traffic-congested area.At that time I managed my rounds quite easily on a bicycle.Unfortunately both your clientele and your colleagues come to regard you as an outsider, which adds to your emotional burden.The car becomes your
Exercise Training Improves Glycemic Control in Long-Standing Insulin-Treated Type 2 Diabetic Patients
Authors: Henk M. De Feyter, Stephan F. Praet, Nicole M. van den Broek, Harm Kuipers, Coen D. Stehouwer, Klaas Nicolay, Jeanine J. Prompers, Luc J.C. van Loon
Journal: Diabetes Care (2007)

Regular exercise represents an effective strategy to prevent and/or treat type 2 diabetes (1,2). However, the clinical benefits of exercise intervention in a vastly expanding group of long-standing insulin-treated type 2 diabetic patients with comorbidities are less evident. As these patients generally experience muscle weakness (3–6), cardiovascular comorbidities (7–10), and/or exercise intolerance (3,11–13), it has proven difficult or even impossible for them to adhere to an intense endurance exercise training regimen (14,15). In the present study, we investigated the feasibility and benefits of a low-impact exercise intervention program, combining both endurance and resistance-type exercise, in long-standing insulin-treated type 2 diabetic patients with a high cardiovascular risk profile. We assessed the impact of 5 months of exercise training on glycemic control, body composition, workload capacity, and whole-body as well as skeletal muscle oxidative capacity.

A total of 11 male type 2 diabetic patients volunteered to participate in this study. Participants (aged 59 ± 3 years, BMI 32 ± 1 kg/m2) had been diagnosed with type 2 diabetes for 12 ± 2 years and had been on exogenous insulin treatment for 7 ± 2 years (insulin requirements 93 ± 11 units/day). All participants were sedentary and showed a …
TREATMENT OF DIPHTHERIA CARRIERS WITH GENTIAN VIOLET
Authors: Edward S. Godfrey
Journal: JAMA (1924)

To the Editor:  —I have read with interest Dr. Saurman's article on this subject (The Journal, July 26). The following case illustrates the possibility of erroneous conclusions being drawn from negative cultures following the use of this dye:  The possibility of gentian violet proving efficacious in the treatment of diphtheria carriers occurred to me following the appearance of Churchman's paper on Selective Bacteriostasis in the Treatment of Infections with Gentian Violet (The Journal, Jan. 17, 1920), and a suitable case for experiment was found in a young woman who had passed through an attack of diphtheria late in November, 1919, and had given positive cultures up to Jan. 31, 1920. A cotton swab saturated with a saturated aqueous solution of gentian violet was pressed against the back of the pharynx, the dye spreading to the tonsils and pharyngeal wall. The attending physician, contrary to instructions, used the solution first, February
A call at Christmas
Authors: E Saphier
Journal: BMJ (1995)

I can still remember my first Christmas night call, 50 years ago. It was to a house called Morus Alba. The patient was having severe abdominal pain. The name must have meant a white tree of some sort, but the headlights had not shown up a tree of any sort. After a while I managed to get to a road of almost the same name. There should not, of course, be a road, a street, a close, and an avenue, all within striking distance of each other …
Ductular reactions in human liver: Diversity at the interface
Authors: Annette S. H. Gouw, Andrew D. Clouston, Neil D. Theise
Journal: Hepatology (2011)

Interest in hepatic ductular reactions (DRs) has risen in recent years because of a greater appreciation of their potential roles in regeneration, fibrogenesis, and carcinogenesis. However, confusion exists because there is significant, but often unappreciated diversity at the tissue, cellular, and subcellular levels in DRs of different diseases and stages of disease. DRs are encountered in virtually all liver disorders in which there is organ-wide liver damage and cell loss, but are also present in focal lesions such as focal nodular hyperplasia and adenoma. Moreover, diverse DR phenotypes can be present within any single disease entity, and are shaped by the etiology and evolution of the disease. Although much remains to be clarified, recent studies suggest that the diversity of appearances of the DRs are likely to reflect the differing signals at the anatomic, cellular, and molecular levels driving the proliferative response. These appear to determine the relative proportions of transit-amplifying cells, the degree of hepatocytic or cholangiocytic differentiation, and their relationships with stromal, vascular, and inflammatory components. The molecular signaling pathways governing these regenerative fate decisions closely replicate those found in human and other vertebrate embryos and more generally in stem cell niches throughout the body. Like the latter, complex interactions with matrix as well as mesenchymal and inflammatory cells, vessels, and innervation are likely to be of fundamental importance. Embracing systems/tissue biological approaches to exploring DRs, in addition to more traditional cellular and molecular biological techniques, will further enhance our understanding and, thereby, we believe potentiate new therapeutic possibilities.
PKD1 Phosphorylation-Dependent Degradation of SNAIL by SCF-FBXO11 Regulates Epithelial-Mesenchymal Transition and Metastasis
Authors: Hanqiu Zheng, Minhong Shen, Yin-Lian Zha, Wenyang Li, Yong Wei, Mario Andres Blanco, Guangwen Ren, Tianhua Zhou, Peter Storz, Hui-Yun Wang, Yibin Kang
Journal: Cancer Cell (2014)
Who wants a career in academic medicine?
Authors: M. Rees
Journal: BMJ (1997)

“Clinical medicine and dentistry are very popular and rewarding professions; biomedical research is one of the most exciting, challenging and productive areas of research today. One might expect the combination of the two, namely clinical academic medicine and dentistry, would be among the most desirable of all professions, but all is not well.” So begins Sir Rex Richards's recently published report on clinical academic careers.1

Why was there a need for such a report? The answer can be found in the disturbing statistics of poor recruitment and retention of Britain's medical academic staff, with 56 vacant chairs and 192 other vacant academic posts in 1995-6, and a steady exodus of senior lecturers out of academic medicine into NHS posts. It can also be found wherever medical academics gather to discuss their careers, as at the recent conference of the BMA's Medical Academic Staff Committee (MASC). Instead of optimistic …
Intraluminal ultrasound imaging through a balloon dilation catheter in an animal model of coarctation of the aorta.
Authors: A Rothman, F Ricou, R G Weintraub, R Crowley, R Arcangeli, T Shiota, J Zhang, D J Sahn
Journal: Circulation (1992)

Controversy still exists over the optimal balloon size, extent of vascular disruption, and long-term results of balloon dilation therapy for coarctation of the aorta. Intravascular ultrasound imaging has been used in patients with coronary artery disease to provide further insight into the anatomy of atherosclerotic lesions and the results of angioplasty and atherectomy. Initial observations of the results of balloon dilation of coarctations with intravascular ultrasound imaging have shown prominent dissections of the inner vascular layers that are often not detected by angiography. The purpose of this study was to test a new transballoon catheter ultrasonic imaging system capable of on-line direct visualization of lumen diameter and vessel wall structure for imaging before, during, and after dilation in an acute animal model of aortic coarctation.Abdominal aortic coarctations were created surgically in three 14-19-kg mongrel dogs by using Teflon gauze ties. The 6.8F ultrasound balloon catheter was placed percutaneously in the right femoral artery through a 9F sheath. Ultrasound imaging allowed measurement of the coarctation diameter, characterization of the vessel wall structure, localization of the stenosis, and placement of the midportion of the balloon at the narrowest area. Imaging through the balloon was performed through several dilations (five to eight per animal), and after balloon deflation, it provided information on postdilation diameter, intimal tears, long-segment dissections, and intramural thrombi, findings that were confirmed at postmortem examination.The results of this study demonstrate that imaging with a new intraballoon ultrasound device is feasible during inflation to therapeutic dilation pressures; it allows visualization of the changes in diameter and vascular wall structure after serial dilations without having to recross the obstructed area. Adaptation to larger balloon sizes and lower frequencies should make this system applicable to interventional catheterizations in patients with congenital cardiac and vascular lesions.
Local delivery of culture-modified mononuclear cells improves endothelial function and attenuates neointimal formation in a rabbit balloon injury model
Authors: Rajiv Gulati, Dragan Jevremovic, Timothy E. Peterson, Tyra A. Witt, Laurel S. Kleppe, Cheryl S. Mueske, Amir Lerman, Richard G. Vile, Robert D. Simari
Journal: Journal of the American College of Cardiology (2003)
Influence of aortic insufficiency on the hemodynamic significance of a coronary artery narrowing.
Authors: R L Feldman, W W Nichols, C J Pepine, C R Conti
Journal: Circulation (1979)

The coronary hemodynamic effects of controlled aortic insufficiency (AI) were studied in 10 dogs. Coronary blood flow (CBF), before and during reactive hyperemia (RH) with graded coronary diameter narrowings (CN), aortic (Ao) and left ventricular (LV) pressures (P), and aortic blood flow (AoF) were recorded. Opening an adjustable basket catheter, positioned across the aortic valve, created reversible AI quantitated from phasic AoF. AI was regulated so that mean CBF was similar with or without AI. During AI, heart rate and systolic AoP were unchanged, but diastolic AoP declined 14 mm Hg (mean) and end-diastolic LVP increased 8 mm Hg, both p less than 0.05. With CN greater than or equal to 85%, mean CBF decreased with or without AI. Coronary resistance was similar with or without AI. During AI with no CN, peak RH CBF declined significantly and was similar to peak RH with 70% CN without AI. Furthermore, AI with 60% CN caused additional reduction in peak RH and was similar to peak RH with 80% CN without AI. These data suggest that CBF reserve, exposed during RH, is decreased during AI. With AI, a given CN has coronary hemodynamic properties similar to higher degrees of CN without AI. These results may relate to clinical findings of ischemia in patients with AI and no or moderate CN.
Allopurinol and the Role of Uric Acid in Hypertension—Reply
Authors: Daniel I. Feig
Journal: JAMA (2009)

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TCT-32 Neurological complications following PCI - incidence and trends during a period of transition from femoral to radial access. Observational data from the british cardiovascular intervention society PCI database
Authors: Karim Ratib, Mamas Mamas, Adrian Large, Samer Arnous, Helen Routledge, Peter Ludman, Doug Fraser, Jim Nolan
Journal: Journal of the American College of Cardiology (2012)
On sickness and on health.
Authors: R Gillon
Journal: BMJ (1986)

The meaning of health, its relation to illness and disease, and its aspects that are of particular importance in medical ethics are the foci of Gillon's essay, one of a series on philosophical medical ethics. He argues that the World Health Organization's definition of health--"a state of complete physical, mental, and social wellbeing and not merely the absence of disease or infirmity"--is too broad for use by physicians in patient care. Defining illness and disease--those components of ill health with which doctors are concerned--might help delineate the physician's role in restoring or preserving health. Gillon summarizes the realist and nominalist approaches to disease and to the question whether it is an evaluative or a value free concept. He suggests that the definition and ascription of illness are of such social importance that decisions concerning them should be made cooperatively by doctors and society.
Observations on the anemia and neutropenia of human copper deficiency
Authors: Bernard L. Zidar, Richard K. Shadduck, Zella Zeigler, Alan Winkelstein
Journal: American Journal of Hematology (1977)

Abstract Following extensive bowel resection, a young woman experienced severe malnutrition; subsequent administration of parenteral nutrition precipitated the copper deficiency syndrome. This consisted of hypocupremia, subnormal ceruloplasmin levels, anemia, and severe neutropenia. The bone marrow was megaloblastic, vacuolated, and sideroblastic; granulocytic maturation was not observed beyond the myelocyte stage. Copper sulfate therapy was followed by a marked reticulocytosis, increase in hematocrit, and recovery of neutrophils. Additional studies indicated that both serum and urinary erythropoietin values were low; serum activity increased after copper supplementation. Abnormal granulopoiesis was demonstrated using the in vitro granulocyte colony assay. The patient's granulocytic stem cells were normal on two occasions; however, mixing studies showed that culture of the patient's copper‐deficient marrow with her copper‐deficient serum yielded significantly reduced numbers of granulocyte colonies. Thus, copper appears to be a necessary element for normal hematopoiesis; lack of this trace element may result in ineffective erythropoiesis and granulopoiesis.