The Collagen and Elastin Content of the Lung in Emphysema
Authors: JOHN A. PIERCE
Journal: Annals of Internal Medicine (1961)

Article1 August 1961The Collagen and Elastin Content of the Lung in EmphysemaJOHN A. PIERCE, M.D., F.A.C.P., JOE B. HOCOTT, M.S., RICHARD V. EBERT, M.D., F.A.C.P.JOHN A. PIERCE, M.D., F.A.C.P.Search for more papers by this author, JOE B. HOCOTT, M.S.Search for more papers by this author, RICHARD V. EBERT, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-2-210 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptConnective tissue fibers maintain the normal arrangement of lung structure. These are scleroprotein fibers: collagen, elastin, and reticulin. They are characterized by their insolubility, their relative permanence, and their high tensile strength. They form a delicate but strong network to suspend those components of the lungs that are essential for the exchange of gases. Pulmonary emphysema is characterized by a distortion of lung architecture, hence is a disturbance in the geometric arrangement of connective tissue fibers in the lungs. Histologic studies in emphysema often have been interpreted as revealing marked changes in the amounts of connective tissues in the lung....References1. LAENNEC RT: A Treatise on Diseases of the Chest, and on Mediate Auscultation, 3rd Ed., translated by Forbes, J., Samuel S. and William Wood, New York, 1838. Google Scholar2. AULD AG: On the minute changes occurring in vesicular emphysema. Lancet 2: 20, 1893. CrossrefGoogle Scholar3. SUDSUKI K: Ueber Lungen—Emphysem. Virchow. Arch. Path. Anat. 157: 438, 1899. CrossrefGoogle Scholar4. TENDELOO NP: Cited by Kountz, W. B. and Alexander, H. L.: Emphysema. Medicine (Balt.) 13: 251, 1934. CrossrefGoogle Scholar5. PIERCEHOCOTTEBERT JAJBRV: Studies of lung collagen and elastin. Amer. Rev. Resp. Dis. 80: 45 (Part II), 1959. MedlineGoogle Scholar6. PIERCEHOCOTT JAJB: Studies on the collagen and elastin content of human lungs. J. Clin. Invest. 39: 8, 1960. CrossrefMedlineGoogle Scholar7. LOWRYGILLIGANKATERSKY OHDREM: The determination of collagen and elastin in tissues, with results obtained in various normal tissues from different species. J. Biol. Chem. 139: 795, 1941. CrossrefGoogle Scholar8. GOUGHWENTWORTH JJE: The use of thin sections of entire organs in morbid anatomical studies. J. Roy. Micr. Soc. 69: 231, 1949. CrossrefMedlineGoogle Scholar9. KRAHLTOBINWYATTLOOSLI VECEJPCG: Report of committee on preparation of human lungs for macroscopic and microscopic study. Amer. Rev. Resp. Dis. 80: 114 (Part II), 1959. Google Scholar10. FLETCHERGILSONHUGH-JONESSCADDING CMJGPJG: Terminology, definitions, and classification of chronic pulmonary emphysema and related conditions. Thorax 14: 286, 1959. CrossrefGoogle Scholar11. HARTROFT WS: The microscopic diagnosis of pulmonary emphysema. Amer. J. Path. 21: 889, 1945. MedlineGoogle Scholar12. LEOPOLDGOUGH JGJ: The centrilobular form of hypertrophic emphysema and its relation to chronic bronchitis. Thorax 12: 219, 1957. CrossrefMedlineGoogle Scholar13. MCLEAN KH: The histology of generalized pulmonary emphysema. II. Diffuse emphysema. Aust. Ann. Med. 6: 203, 1957. CrossrefMedlineGoogle Scholar14. NEERGAARD KV: [New ideas concerning a fundamental concept of respiratory mechanics. The retractive force of the lungs, dependent on the surface tension in the alveoli.] Z. Ges. Exp. Med. 66: 373, 1929. CrossrefGoogle Scholar15. PIERCEHOCOTTHEFLEY JAJBBF: Elastic properties and the geometry of the lungs. J. Clin. Invest. To be published. Google Scholar16. BRISCOELORING AMWE: Elastin content of the human lung. Proc. Soc. Exp. Biol. Med. 99: 162, 1958. CrossrefMedlineGoogle Scholar17. BRISCOELORINGMCCLEMENT AMWEJH: Changes in human lung collagen and lipids with age. Proc. Soc. Exp. Biol. Med. 102: 71, 1959. CrossrefMedlineGoogle Scholar18. WRIGHTKLEINERMANZORN GWJEM: The elastin and collagen content of normal and emphysematous human lungs. Amer. Rev. Resp. Dis. 81: 938, 1960. Google Scholar19. SCARSELLIREPETTO VM: Il contenuto in elastina del polmone umano in funzione dell'eta. Boll. Soc. Ital. Biol. Sper. 35: 191, 1959. MedlineGoogle Scholar20. ROBB-SMITH AH: The relationship of reticulin to other "collagens," in Stainsby, G., Recent Advances in Gelatin and Glue Research, Pergamon Press, New York, 1958. Google Scholar21. LOOSLIPOTTER CGEL: Pre- and postnatal development of the respiratory portion of the human lung. Amer. Rev. Resp. Dis. 80: 5 (Part II), 1959. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Little Rock, ArkansasReceived for publication March 23, 1961.From the Department of Medicine, University of Arkansas Medical Center, Little Rock, Ark.Presented in part at the Forty-first Annual Meeting of The American College of Physicians, San Francisco, Calif., April 6, 1960.Supported by Grant H-4031 from the National Institutes of Health.Requests for reprints should be addressed to John A. Pierce, M.D., Associate Professor of Medicine, Department of Medicine, University of Arkansas Medical Center, Little Rock, Ark. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLong-Term Sequelae of Smoking and Cessation in Spontaneously Hypertensive RatsPulmonary Disease in the Older AdultJoint Transcriptomic Analysis of Lung Cancer and Other Lung DiseasesSterilization of Lung Matrices by Supercritical Carbon DioxideDoes lysozyme play a role in the pathogenesis of COPD?Physiologic Changes in Respiratory FunctionDiseases of the conductive airwaysExtracellular MatrixAvaliação quantitativa das fibras elásticas na doença pulmonar obstrutiva crônicaQuantitative and O 2 Enhanced MRI of the Pathologic Lung: Findings in Emphysema, Fibrosis, and Cystic FibrosisT1-Maps und O2-verstärkte MRT der erkrankten LungeThe Pathogenesis and Pathophysiology of EmphysemaExtracellular matrixPathogenesis of COPDPhysiologic Changes in Respiratory FunctionDegradation and repair of elastic fibers in rat lung interstitial fibroblast culturesThe influence of maternal nicotine exposure on the status of the connective tissue framework of developing rat lungQuantitative Studies of Human Lung Airspace Wall in Relation to Collagen and Elastin ContentCollagen and Elastin in Human Pulmonary EmphysemaEmphysema: The First Two Centuries-and Beyond: A Historical Overview, with Suggestions for Future Research: PartElastin and the LungEmphysema Before and After 1963Transforming Growth Factor- β Increases Elastin Production by Neonatal Rat Lung FibroblastsStructural Crosslinking of Lung Connective Tissue Collagen in the Blotchy MouseThe Aging Respiratory SystemEffects of Pneumotoxins on Lung Connective TissueMechanisms of Lung Injury in the Copper-Deficient Hamster Model of EmphysemaElastin-Lysine Derived Cross-Links Structure, Biosthesis, and Relation to Lung Emphysema PathogenesisThe Reticuloendothelial System and Tissue InjuryMethods and Results of Postmortem Studies of Airway Dynamics in Normal Lungs and Lungs with Minimal ObstructionLung Connective TissueIncreased Content of Neutrosoluble Collagen and Dialyzable Hydroxyproline in Panacinar Emphysema and Spontaneous PneumothoraxResistance of tropoelastin and elastin peptides to degradation by α2-macroglobulin-protease complexesElastin Structure, Biosynthesis, and Relation to Disease StatesConnective Tissues and the Mechanical Behavior of LungsProteolytic Mechanisms and Pulmonary EmphysemaLUNG SCLEROPROTEINS IN YOUNG AND ADULT RAT AND IN RAT WITH SPONTANEOUS EMPHYSEMA : COMPARATIVE STUDY BY BIOCHEMICAL AND HISTOCHEMICAL APPROACHTHE TISSUE RESPONSE TO EXOGENOUS ELASTASELUNG ELASTIN CONTENT IN NORMAL AND EMPHYSEMATOUS LUNGSCorrelation between biochemical and morphological repair in rabbit lungs after elastase injuryElastin content of normal and emphysematous lung parenchymaThe role of elastases in the development of emphysemaUltrastructural alterations in collagen associated with microscopic foci of human emphysemaNormal Newborn and Adult Human Lung Collagen — Analysis of TypesLung distensibility. The static pressure-volume curve of the lungs and its use in clinical assessmentThe pathology of elastase-induced panacinar emphysema in hamstersPregnancyMechanisms of pulmonary injuryAorta, Heart and Lung Vessels in Idiopathic Pulmonary Emphysema Related to Pulmonary FunctionEffect of Proteolytic Enzymes on Collagen and Non-Collagen Protein Synthesis in Human Lung FibroblastsDevelopmental Aspects of the Human LungDisorders of elastic tissue: A reviewLocalization and chemical composition of elastin in ox lungLung Scleroproteins in Age and EmphysemaAlpha-1-Antitrypsin und LungenemphysemConnective Tissue and LymphaticsElasticity of the Lung in Pulmonary EmphysemaRICHARD V. EBERT, M.D., F.A.C.P.The Structure ProteinsElastinAge Related Changes in the Fibrous Proteins of the Lungs 1 August 1961Volume 55, Issue 2Page: 210-222KeywordsConnective tissueEmphysemaLungs Issue Published: 1 August 1961 PDF downloadLoading ...