tbuckley/cabot-search huggingface dataset:
Chronic Erythema Nodosum Treated with Indomethacin
Authors: WALTER G. BARR
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 November 1981Chronic Erythema Nodosum Treated with IndomethacinWALTER G. BARR, M.D., JOHN A. ROBINSON, M.D.WALTER G. BARR, M.D.Search for more papers by this author, JOHN A. ROBINSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-5-659_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Erythema nodosum is a cutaneous reaction characterized by the acute eruption of tender nodules in the subcutaneous tissues. It has been associated with infections, drugs, sarcoidosis, and enteropathies, but in many cases the cause remains unknown. The anterior lower extremities are most prominently affected. Typically the initially red, shiny patches become violacious and nodular with the complete healing process leaving only a residual "bruise." A delayed hypersensitivity reaction involving the subcutaneous fat is thought to underlie its pathogenesis (1). A short self-limited course is the rule but some patients remain symptomatic for as long as 8 years...References1. ACKERMAN A. Histological Diagnosis of Inflammatory Skin Diseases. Philadelphia: Lea and Febeger; 1978. Google Scholar2. FINE R and MELTZER H. Chronic erythema nodosum. Arch Dermatol. 1969;100:33-8. CrossrefMedlineGoogle Scholar3. ARNDT K. Manual of Dermatologic Therapeutics. Boston; Little, Brown and Company, 1978. Google Scholar4. GOODWIN J, SELINGER D, MESSNER R, and REED W. Effect of indomethacin in vivo on humoral and cellular immunity in humans. Infect Immunol. 1978;19:430-3. CrossrefMedlineGoogle Scholar5. LEHMAN C. Control of chronic erythema nodosum with naproxen. Cutis. 1980;26:66-7. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WALTER G. BARR, M.D.; JOHN A. ROBINSON, M.D.Affiliations: Loyola University Stritch School of Medicine Maywood, IL 60153 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA Novel Adverse Event Associated with Olaparib Therapy in a Patient with Metastatic Breast CancerÉrythème noueuxNSAIDs in Dermatologic Therapy: Review and PreviewErythema Nodosum in Children: A Study of 27 PatientsUnilateral plantar erythema nodosumDermatologic therapy: December, 1980, through November, 1981Erythema Nodosum and IndomethacinFORTUNATO V. ELIZAGA, M.D. 1 November 1981Volume 95, Issue 5 Page: 659-659 Keywords Drugs Enteropathies Erythema Fats Hypersensitivity Pathogenesis Sarcoidosis ePublished: 1 December 2008 Issue Published: 1 November 1981 PDF downloadLoading ...
A Public Health Approach to Gun Violence
Authors: James R. Gould
Journal: Annals of Internal Medicine (2013)

Letters20 August 2013A Public Health Approach to Gun ViolenceJames R. Gould, MDJames R. Gould, MDFrom Oncology Associates of Western Kentucky, Paducah, Kentucky.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-4-201308200-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:As a physician with nearly 40 years' experience, I have no role in gun violence prevention. First, I don't get paid for my current tasks. Second, the kind words I offer to obese or underactive patients and those with medically uncontrolled conditions already fall on deaf ears. (Advice to pathologic psyches?) Third, the system of mental health support collapsed decades ago. Don't shift the burden of prevention to those who cannot get their primary jobs done. Fourth, the criminal justice system is not allowed to do its job: punish and restrict the freedoms of the convicted. We ...Reference1. Frattaroli S, Webster DW, and Wintemute GJ. Implementing a public health approach to gun violence prevention: the importance of physician engagement. Ann Intern Med. 2013;158:697-8 LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: James R. Gould, MDAffiliations: From Oncology Associates of Western Kentucky, Paducah, Kentucky.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoImplementing a Public Health Approach to Gun Violence Prevention: The Importance of Physician Engagement Shannon Frattaroli , Daniel W. Webster , and Garen J. Wintemute A Public Health Approach to Gun Violence Shannon Frattaroli , Daniel W. Webster , and Garen J. Wintemute A Public Health Approach to Gun Violence John P. May Metrics 20 August 2013Volume 159, Issue 4Page: 306KeywordsFallsMedical conditionsOverweightPrevention, policy, and public healthPsychiatry and mental healthViolent crime ePublished: 20 August 2013 Issue Published: 20 August 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 5706: High-throughout library screening identifies phytochemical inducers of phase II metabolism enzymes <i>GSTP1</i> and <i>NQO1</i> in human lung cells
Authors: Xiang-Lin Tan, Miao Shi, Aldo Massimi, Weiguo Han, Simon Spivack
Journal: Cancer Research (2010)

Abstract Many phytochemicals possess anti-oxidant and cancer-preventive properties, some putatively through phase II metabolism-mediated mutagen/oxidant quenching. However, in studies to date, most candidate agents are not active in human lung cells. In vitro and in vivo screening studies for discovery are clearly needed for new, more potent chemopreventive agents for lung cancer. Here we applied an mRNA-specific gene expression-based high-throughout screening approach to identify phytochemical inducers of phase II metabolism enzymes GSTP1 and NQO1 in primary normal human bronchial epithelial (NHBE) cells and immortalized human bronchial epithelial cells (HBEC). We have screened 800 compounds in the MicroSource Natural Products Library for inducers of GSTP1 and NQO1 expression, and identified 2, 3-dihydroxy-4-methoxy-4′-ethoxybenzophenone, triacetylresveratrol, ivermectin, sanguinarine sulfate, and daunorubicin as new inducers for GSTP1 and NQO1 mRNA expression. Consistent with this effect, the induction of NQO1 protein expression by immunoblot was found for all these agents in both HBEC and NHBE cells at the same concentration that induced NQO1 mRNA expression. However, GSTP1 protein expression did not significantly change with any selected agents. Proliferation/viability assays showed that HBEC and NHBE were significantly inhibited by ivermectin, sanguinarine sulfate, and daunorubicin. These data demonstrate the feasibility of high-throughput screening for inducers of NQO1. Moreover, the data identify 2, 3-dihydroxy-4-methoxy-4′-ethoxybenzophenone and triacetylresveratrol as the most potent and low toxicity inducers [≥3-6-fold, at the protein level], implying they are potential new agents for further in vitro and preclinical in vivo testing for prevention of oxidant-related disease. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5706.
Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation
Authors: Robert B. Boxer, Douglas B. Stairs, Katherine D. Dugan, Kathleen L. Notarfrancesco, Carla P. Portocarrero, Blaine A. Keister, George K. Belka, Han Cho, Jeffrey C. Rathmell, Craig B. Thompson, Morris J. Birnbaum, Lewis A. Chodosh
Journal: Cell Metabolism (2006)
Colchicine Treatment for the Prevention of Bare-Metal Stent Restenosis in Diabetic Patients
Authors: Spyridon Deftereos, Georgios Giannopoulos, Konstantinos Raisakis, Charalambos Kossyvakis, Andreas Kaoukis, Vasiliki Panagopoulou, Metaxia Driva, George Hahalis, Vlasios Pyrgakis, Dimitrios Alexopoulos, Antonis S. Manolis, Christodoulos Stefanadis, Michael W. Cleman
Journal: Journal of the American College of Cardiology (2013)
Successful Treatment of a Post-operative External Biliary Fistula by Endoscopic Papillotomy
Authors: S. O'Rahilly, J.P. Duignan, J.R. Lennon, E. O'Malley
Journal: Endoscopy (1983)

A patient presenting with a bile collection in his abdominal wound following an oesophagogastrectomy was found to have an external biliary fistula. The obstruction in the common bile duct was due to gallstones. The patient underwent endoscopic papillotomy and his fistula closed without further surgery.
198 GLUT1 EXPRESSION IN HEPATOCELLULAR CARCINOMA: CORRELATION WITH F-FDG UPTAKE
Authors: A.F. Brito, A.M. Abrantes, C. Pinto-Costa, A.C. Mamede, C. Matos, M.C. Rodrigues, A.C. Goncalves, A. Rodrigues, A.B. Sarmento-Ribeiro, F. Castro-Sousa, M.F. Botelho, J.G. Tralhao
Journal: Journal of Hepatology (2011)
1034. Automated Retroviral Insertion Site Sequence Analysis and Mapping Tool followed by Database Analysis
Authors: Stephanie Laufs, Frank A. Giordano, Agnes Hotz-Wagenblatt, Uwe Appelt, Daniel Lauterborn, Kurt Fellenberg, W. Jens Zeller, Stefan Fruehauf
Journal: Molecular Therapy (2005)

Increasing use of hematopoietic stem cells for retroviral vector-mediated gene therapy and recent reports on leukemogenesis in mice and humans have created intense interest to characterize vector integrations on the genomic level.
Generics manufacturer Apotex files lawsuit against Health Canada over import ban
Authors: O. Dyer
Journal: BMJ (2014)

Canada’s health ministry and the country’s largest manufacturer of generic drugs, Apotex, long accused of an overly cosy relationship, are locked in a bitter legal battle after the Canadian health minister, Rona Ambrose, banned the import of all drugs and ingredients made in two Apotex plants in Bangalore, India.

Health Canada twice asked Apotex to halt imports from one plant over quality concerns, but the company refused. The minister then banned the products and said that trust between the regulator and the manufacturer had been “broken.” Apotex responded with a lawsuit alleging that Health Canada had acted with “malice” and had folded to pressure from the media and the opposition. “The minister’s decision to implement the import ban was politically motivated and, in particular, was calculated to deflect public and parliamentary criticism of the …
Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury.
Authors: H E Gruber, M E Hoffer, D R McAllister, P K Laikind, T A Lane, G W Schmid-Schoenbein, R L Engler
Journal: Circulation (1989)

Morbidity and mortality from acute coronary artery occlusion may be reduced if local myocardial adenosine concentration is augmented because 1) coronary collateral blood flow during ischemia increases with adenosine infusion, and 2) granulocytes that accumulate in the microcirculation during ischemia are, to a large extent, inhibited by adenosine from generating superoxide anion free radicals, from adhering to vascular endothelium, and from damaging endothelial cells in culture. Using a cultured lymphoblast model system, we found that 5-amino-4-imidazole carboxamide (AICA) riboside enhanced adenosine accumulation during ATP catabolism. Therefore, AICA riboside pretreatment was used in canine myocardium to selectively increase adenosine concentration in the ischemic area during 1 hour of ischemia. At 5 minutes of ischemia, endocardial flow to ischemic myocardium in saline-treated and AICA riboside-treated dogs was 0.06 +/- 0.03 and 0.34 +/- 0.11 ml/min/g, respectively (p less than 0.01); flow to nonischemic myocardium was not affected. Ventricular tachycardia and premature ventricular depolarizations were significantly attenuated in the AICA riboside-treated dogs. Blood pressure and heart rate were not affected by AICA riboside. In venous blood from ischemic tissue, adenosine increased from undetectable levels (less than 0.01 microM) to 0.22 +/- 0.08 microM in saline and 1.79 +/- 0.06 microM in AICA riboside-treated dogs, respectively (p less than 0.001). Coronary vein inosine concentrations were greater in saline than in AICA riboside-treated dogs. In separate in vitro studies, AICA riboside did not alter the removal rate of adenosine from canine blood. Indium-labeled granulocyte accumulation was significantly less in ischemic myocardium in AICA riboside-treated compared with saline-treated dogs. In addition, adenosine, but not AICA riboside, inhibited in vitro canine granulocyte superoxide production. We conclude that AICA riboside given before myocardial ischemia augments adenosine concentration, decreases arrhythmias, decreases granulocyte accumulation, and improves collateral flow to ischemic myocardium. One of the beneficial mechanisms could be an increased production of adenosine rather than inosine from ATP catabolism that causes vasodilation and inhibition of granulocytes. We propose a new hypothesis regarding regulation of the inflammatory reaction to ischemia in the microcirculation. Adenosine, in addition to its vasodilator action, is an anti-injury autacoid that links ATP catabolism to inhibition of granulocyte adherence, microvascular obstruction, and superoxide anion formation.
Relationship between the amount of rice oil ingested by patients with yusho and their subjective symptoms.
Authors: T Yoshimura, H Hayabuchi
Journal: Environmental Health Perspectives (1985)

The goal of this study was to clarify the subjective symptoms closely related to yusho by examining the relationship between the amount of PCB-contaminated rice oil ingested by patients and the subjective symptoms recorded on their questionnaires. The amount of PCB-contaminated rice oil consumed by the patients was obtained by interviewing the housewife in each yusho family. Individual consumption of the oil was estimated by taking into account age, sex and the number of meals at home. In 1970, 46 patients were available for analysis, and in 1971, 33 patients were available. Among 12 subjective symptoms studied, numbness of the limbs, coughing, expectoration, and the sensation of "elevated" teeth were considered to show a dose-response relationship, which suggests that these subjective symptoms are closely related to yusho. Consistent high rates of complaints of general fatigue and eye discharge were considered possibly to be connected with yusho, although no dose-response relationships have been determined. Other subjective symptoms, such as fever, headache, dizziness, abdominal pain, swelling in the joints, changes in menstruation, and loss of hair failed to show consistent dose-response relationships. It should be noted, however, that for these symptoms which failed to show dose-response relationships, it is impossible to deny a causal relationship.
Fear Conditioning Enhances Different Temporal Components of Tone-Evoked Spike Trains in Auditory Cortex and Lateral Amygdala
Authors: Gregory J Quirk, Jorge L Armony, Joseph E LeDoux
Journal: Neuron (1997)

Single neurons were recorded in freely behaving rats during fear conditioning from areas of auditory cortex that project to the lateral nucleus of the amygdala (LA). The latency and rate of conditioning and extinction were analyzed, and the results were compared to previous recordings from LA itself. Auditory cortex neurons took more trials to learn, and they responded more slowly than LA neurons within trials. Short-latency plasticity in LA, therefore, reflects inputs from the auditory thalamus rather than the auditory cortex. Unlike LA cells, some auditory cortex cells showed late conditioned responses that seemed to anticipate the unconditioned stimulus, while others showed extinction-resistant memory storage. Thus, rapid conditioning of fear responses to potentially dangerous stimuli depends on plasticity in the amygdala, while cortical areas may be particularly involved in higher cognitive (mnemonic and attentional) processing of fear experiences.
Reversal of Multidrug Resistance by Transduction of Cytokine Genes Into Human Colon Carcinoma Cells
Authors: Ulrike Stein, Wolfgang Walther, Robert H. Shoemaker
Journal: JNCI Journal of the National Cancer Institute (1996)

Background:Multidrug resistance can be a major obstacle to successful cancer chemotherapy and is often associated with increased expression of the mdr1 (also known as P-glycoprotein) gene. Some of the proteins produced by the body's immune system, i.e., cytokines such as tumor necrosis factor-α (TNF) and interleukin 2 (IL-2), have been shown to modulate multidrug resistance. However, cytokines administered by the conventional intravenous method can cause severe side effects. Transduction of cytokine genes into tumor cells constitutes an alternative approach for production and release of the cytokine proteins in the local tumor microenvironment, which may reduce problems of toxicity associated with systemic administration.
Single dose topical corticosteroid inhibits IL‐5 and IL‐13 in nasal lavage following grass pollen challenge
Authors: E. M. Erin, B. R. Leaker, A. S. Zacharasiewicz, L. A. Higgins, T. J. Williams, M. J. Boyce, P. de Boer, S. R. Durham, P. J. Barnes, T. T. Hansel
Journal: Allergy (2005)

Background: Nasal lavage is a noninvasive method of obtaining inflammatory exudates following nasal allergen challenge (NAC), and permits cells and released mediators to be evaluated. Objective: To determine the effects of a single dose of topical steroid on eosinophils and levels of chemokines and cytokines in nasal lavage fluid following NAC in patients with allergic rhinitis. Methods: Patients with grass pollen seasonal allergic rhinitis ( n = 32) out of the allergy season received either nasal budesonide (100 μ g per nostril) or matched placebo before allergen challenge in a double blind two‐way crossover design. A semi‐automated mixed bead array system was employed to measure multiple chemokines and cytokines in small volumes (50 μ l) of nasal lavage supernatants. Results: Following NAC there was a rapid onset of nasal symptoms together with nasal eosinophilia, and the appearance of IL‐5 and IL‐13 in lavages between 4 and 8 h. Elevated levels of eotaxin, RANTES, IL‐8 and MCP‐1 were also detected following allergen challenge. A single dose of nasal budesonide caused a decrease in symptoms ( P &lt; 0.05) and nasal eosinophils ( P &lt; 0.05) with selective abrogation of IL‐5 and IL‐13 responses ( P &lt; 0.05), but a lack of effect on levels of eotaxin, RANTES, IL‐8 and MCP‐1. Conclusion: This study suggests that a single dose of nasal steroid has the capacity to selectively abolish IL‐5 and IL‐13 responses following NAC. This model should be convenient for testing novel anti‐inflammatory and immunoregulatory agents intended for the treatment of allergic rhinitis.
The potential role of orbicules as a vector of allergens
Authors: S. Vinckier, E. Smets
Journal: Allergy (2001)

In the locules of anthers of flowering plants, tiny (1.5-2 microm) granules of sporopollenin may occur next to the pollen grains. Those granules, called orbicules, mostly occur on the radial and innermost tangential wall of secretory tapetum cells.We have investigated the presence of orbicules in 15 important European allergenic species with scanning electron microscopy (SEM).Orbicules were present in all species investigated of the families Betulaceae, Chenopodiaceae, Fagaceae, Poaceae, Polygonaceae, and Urticaceae. However, in the Asteraceae and Oleaceae species studied, orbicules were lacking. In all Chenopodiaceae, Poaceae, and Urticaceae species, orbicules were attached to the pollen exine. These observations indicate the possibility of the dispersal of orbicules into the atmosphere during anthesis.The hypothesis of the potential role of orbicules as possible important vectors of allergens is put forward, based on the comparison of our results with recent literature about the evidence of allergenic activity in the smaller micronic atmospheric aerosol fraction. Our results provide evidence that an in-depth investigation of the sites of allergens across the whole anther is required. We suggest that allergen researchers apply immunoelectron microscopy on whole anthers to determine whether orbicules possess allergens.
<scp>l</scp> -Arginine Supplementation in Peripheral Arterial Disease
Authors: Andrew M. Wilson, Randall Harada, Nandini Nair, Naras Balasubramanian, John P. Cooke
Journal: Circulation (2007)

L-arginine is the precursor of endothelium-derived nitric oxide, an endogenous vasodilator. L-arginine supplementation improves vascular reactivity and functional capacity in peripheral arterial disease (PAD) in small, short-term studies. We aimed to determine the effects of long-term administration of L-arginine on vascular reactivity and functional capacity in patients with PAD.The Nitric Oxide in Peripheral Arterial Insufficiency (NO-PAIN) study was a randomized clinical trial of oral L-arginine (3 g/d) versus placebo for 6 months in 133 subjects with intermittent claudication due to PAD in a single-center setting. The primary end point was the change at 6 months in the absolute claudication distance as assessed by the Skinner-Gardner treadmill protocol. L-arginine supplementation significantly increased plasma L-arginine levels. However, measures of nitric oxide availability (including flow-mediated vasodilation, vascular compliance, plasma and urinary nitrogen oxides, and plasma citrulline formation) were reduced or not improved compared with placebo. Although absolute claudication distance improved in both L-arginine- and placebo-treated patients, the improvement in the L-arginine-treated group was significantly less than that in the placebo group (28.3% versus 11.5%; P=0.024).In patients with PAD, long-term administration of L-arginine does not increase nitric oxide synthesis or improve vascular reactivity. Furthermore, the expected placebo effect observed in studies of functional capacity was attenuated in the L-arginine-treated group. As opposed to its short-term administration, long-term administration of L-arginine is not useful in patients with intermittent claudication and PAD.