Adverse Effects with Acyclovir and Meperidine
Authors: R. JOHNSON
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 December 1985Adverse Effects with Acyclovir and MeperidineR. JOHNSON, M.D., J. DOUGLAS, M.D., L. COREY, M.D., HARVEY KRASNEY, M.D.R. JOHNSON, M.D.Search for more papers by this author, J. DOUGLAS, M.D.Search for more papers by this author, L. COREY, M.D.Search for more papers by this author, HARVEY KRASNEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-6-962_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We write to share our experience of a patient treated with acyclovir and meperidine with serious consequences.A 54-year-old man with stage IVA Hodgkin's disease in remission was admitted with localized herpes zoster of the left thigh. Treatment was initiated with intravenous acyclovir, 875 mg (500 mg/m2) given over 1 hour at 8-hour intervals. Intramuscular meperidine, oral methadone, and carbidopa-levodopa were administered for control of cutaneous pain, and intravenous fluids were provided at a rate of 100 mL/h. On the second day the patient developed nausea, vomiting, and confusion. The carbidopa-levodopa (cumulative, 30 mg of carbidopa and...References1. WHITLEYBLUMBARTONDE MIRANDA RMNP. Pharmacokinetics of acyclovir in humans following intravenous administration. Am J Med. 1982;73(1A):165-71. CrossrefMedlineGoogle Scholar2. LASKINLONGSTRETHWELTON OJA. Effect of renal failure on the pharmacokinetics of acyclovir. Am J Med. 1982;73(1A):197-201. CrossrefMedlineGoogle Scholar3. BEANAEPPLI BD. Adverse effects of high-dose intravenous acyclovir in ambulatory patients with acute herpes zoster. J Infect Dis. 1983;151:362-5. CrossrefGoogle Scholar4. BRIGDENROSLINGWOODS DAN. Renal function after acyclovir intravenous injection. Am J Med. 1982;73(1A):182-5. CrossrefMedlineGoogle Scholar5. SZETOINTURRISIHONDESAALCHEIGHREIDENBERG HCRSJM. Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure or cancer. Ann Intern Med. 1977;86:738-41. LinkGoogle Scholar6. KAIKOFOLEYGRABINSKI RKP. Central nervous system excitatory effects of meperidine in cancer patients. Ann Neurol. 1983;13:180-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Washington Seattle, WA 98195 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMedikamentös induzierte Psychose bei einer HIV-infizierten PatientinDistinguishing acyclovir neurotoxicity from encephalomyelitisAcyclovir-induced neurotoxicity: Concentration-side effect relationship in acyclovir overdoseAcyclovir Neurotoxicity and Nephrotoxicity-The Role for HemodialysisMeperidine NeurotoxicityTherapy and Prevention of Cytomegalovirus InfectionsMiscellaneous antibacterial and antiviral drugsCorrection: Effects of Acyclovir and MeperidineLAWRENCE COREY, M.D., JOHN DOUGLAS, M.D.Drug Interactions and Adverse Reactions 1 December 1985Volume 103, Issue 6_Part_1Page: 962-963KeywordsHodgkin lymphomaNauseaVomiting Issue Published: 1 December 1985 PDF DownloadLoading ...