The Idiopathic Long Q-T Syndrome
Authors: PETER J. SCHWARTZ
Journal: Annals of Internal Medicine (1983)

Editorials1 October 1983The Idiopathic Long Q-T SyndromePETER J. SCHWARTZ, M.D.PETER J. SCHWARTZ, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-4-561 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptProlongation of the Q-T interval is associated with increased risk of sudden cardiac death (1), whether idiopathic (2), secondary to drugs and electrolyte imbalance (3), or associated with ischemic heart disease (4). The drugs more commonly associated with Q-T prolongation and ventricular fibrillation are quinidine, disopyramide, prenylamine, phenothiazine, and tricyclic antidepressants. Thioridazine probucol, Sotalol, procainamide, and encainide have also been associated with Q-T prolongation and malignant arrhythmias. The antiarrhythmic drug amiodarone is unique in that it prolongs the Q-T interval but, as this phenomenon is secondary to a uniform prolongation of all ventricular action potentials, the net effect is a...References1. MOSSSCHWARTZ AP. Delayed repolarization (QT or QTU prolongation) and malignant ventricular arrhythmias. Mod Concepts Cardiovasc Med. 1982;51:85-90. MedlineGoogle Scholar2. SCHWARTZ P. The long Q-T syndrome. In: KULBERTUS HE, WELLENS HJJ, eds. Sudden Death. The Hague: M. Nijhoff; 1980:358-78. CrossrefGoogle Scholar3. SCHWARTZMOSS PA. Q-T interval prolongation. What does it mean? J Cardiovasc Med. 1982;7:1317-30. Google Scholar4. SCHWARTZWOLF PS. QT interval prolongation as predictor of sudden death in patients with myocardial infarction. Circulation. 1978;57:1074-7. CrossrefMedlineGoogle Scholar5. SCHWARTZPERITIMALLIANI PMA. The long Q-T syndrome. Am Heart J. 1975;89:378-90. CrossrefMedlineGoogle Scholar6. JERVELLLANGE-NIELSEN AF. 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Author, Article, and Disclosure InformationAffiliations: University of Milan Milan Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByBorderline and Long QT Syndrome in Adolescent Athletes Taking MedicationsVideo-Assisted Modified Left Sympathectomy for Long-QT SyndromeThe long Q-T syndromesNonepileptic Paroxysmal Events in ChildhoodRoutine Monitoring of the Electrocardiogram Q-T Interval in the EEG LaboratoryHuman ventricular repolarization and T wave genesisElectroencephalography laboratory diagnosis of prolonged QT intervalFamilial ventricular tachycardia: a report of four families.Surgical Treatment of Dysrhythmias in Infants and ChildrenHereditary long Q-T syndrome presenting as epilepsy: Electroencephalography laboratory diagnosisCardiac arrhythmia surgeryHereditary Long QT Syndrome Associated with Cardiac Conduction System DiseaseSudden cardiac arrest in morbidly obese surgical patients unexplained after autopsyEfficacy and safety of oral nadolol for exercise-induced ventricular arrhythmiasJervell and Lange-Nielsen syndrome in a middle aged patient.The QT-Sensitive Cybernetic Pacemaker: A New Role for an Old Parameter?Morphologic Alterations in the Long Q-T Syndrome.The conduction system in patients with a prolonged QT intervalCurrent Status of Surgery for Ventricular TachyarrhythmiasIdiopathic long QT syndrome: Progress and questionsQT prolongation and arrhythmia suppressionEfficacy of left cardiac sympathectomy in the treatment of patients with the long QT syndrome.THE RATIONALE AND THE ROLE OF LEFT STELLECTOMY FOR THE PREVENTION OF MALIGNANT ARRHYTHMIASBeta-adrenoceptor blockade: Electrophysiology and antiarrhythmic mechanismsLong QT: Good, bad or indifferent? 1 October 1983Volume 99, Issue 4Page: 561-562KeywordsAction potentialsAntidepressantsArrhythmiaCardiovascular therapyDrugsPhenothiazineSudden cardiac deathTricyclic antidepressantsVentricular fibrillation Issue Published: 1 October 1983 PDF DownloadLoading ...