tbuckley/cabot-search huggingface dataset:
Case against Christian GP is adjourned to try to persuade patient to give evidence
Authors: C. Dyer
Journal: BMJ (2011)

A Christian GP accused of “crossing the line” in discussing religion with a vulnerable patient won a temporary reprieve when the General Medical Council adjourned the case against him to make another attempt to persuade the patient to give evidence.

The GMC had proposed giving Richard Scott a warning about his behaviour, but he refused to accept it and opted instead for an oral hearing before its investigations committee.

On 23 September, the second day of the two day hearing in Manchester, the committee adjourned “to make a further attempt to secure the attendance of Patient A,” who has …
Germany to reform GP training
Authors: S. Goldbeck-Wood
Journal: BMJ (1997)

The German medical association held its 100th annual conference in Eisenach (in the former East Germany) two weeks ago. Sandra Goldbeck-Wood reports.

The German medical association has agreed radical changes to GP training–from 2005, GPs will need to train for five years rather than the current three after registration.

Up to three years of this lengthened training may be spent in general practice, with one and a half years as a minimum. Trainees will also spend at least a year in internal medicine and six months each in child health and surgery. The remaining two years can be spent in a series of optional specialties, both in hospitals and in office based practices.



Professor Hoppe, President Herzog, and Dr Villmar

JOHANNES AEVERMANN



The reforms are intended to boost flagging public confidence in GPs, according to Professor Jorg Hoppe, vice president …
Search for Oz
Authors: Catherine V. Caldicott, Deirdre Neilen
Journal: Annals of Internal Medicine (2008)

Medical Writings: Book Notes1 April 2008Search for OzCatherine V. Caldicott, MD and Deirdre Neilen, PhDCatherine V. Caldicott, MDFrom the State University of New York Upstate Medical University, Syracuse, New York.Search for more papers by this author and Deirdre Neilen, PhDFrom the State University of New York Upstate Medical University, Syracuse, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-7-200804010-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Search for OzBronson R. 102 pages. Cold Spring Harbor, NY: Padishah Pr; 2006. $16.00. ISBN 9780977640522. Order at www.padishahpress.com.Field of medicine: Medical humanities.Format: Softcover book.Audience: Poetry lovers, especially those in the medical field.Purpose: To celebrate both the everyday and the extraordinary in medicine and in the life of the physician.Content: Sixty-one poems in 3 sections provide a highly personal glimpse into the world of a physician who sees himself and his world in images from art, music, and history.Highlights: Almost every poem has 2 stories to tell— the contemporary one that the speaker ... Author, Article, and Disclosure InformationAffiliations: From the State University of New York Upstate Medical University, Syracuse, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 2008Volume 148, Issue 7Page: 568KeywordsEmotionsMedical ethics, humanities, and educationSleepSoftware toolsWalking ePublished: 1 April 2008 Issue Published: 1 April 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
CLINICAL EXPERIENCES WITH THE APPENDICULO-OVARIAN LIGAMENT.
Authors: DANIEL H. CRAIG
Journal: JAMA (1904)

Notwithstanding the fact that a rather extensive study of the literature of the subject has convinced me that no such structure as the appendiculo-ovarian ligament, as an independent entity, exists, and that there is neither reason nor professional justice in the association of the name of Clado<sup>1</sup>with the structure thus named by him, I have retained that nomenclature in the title of this paper because, largely through the writings of Durand,<sup>2</sup>the name has become fairly well known to the gynecologists and abdominal surgeons of America. I can not better justify the above statement of opinion than by quoting directly from the exhaustive monograph of Nagel,<sup>3</sup>in which he says: "The plica genitoenterica, as described by Treitz in 1857, was known long before the work of Clado and Durand, and it is not becoming that this fold should be associated with the name of Clado, as the
Central excitation and inhibitory mechanisms and neuroplasticity are also manifested in trigeminal nociceptive pathways
Authors: James W. Hu, Barry J. Sessle
Journal: Behavioral and Brain Sciences (1997)

Central sensitization and related neurochemical mechanisms are also induced in V nociceptive pathways after craniofacial injury or inflammation. Their characteristics raise additional possibilities that may explain some of the phenomena outlined by coderre &amp; katz, dickenson, and wiesenfeld-hallin et al. They also underscore the need for therapeutic approaches to reduce nociceptive inputs to the CNS or their neuroplastic effects which can potentially enhance post-traumatic pain.
Activated Charcoal in Tricyclic Drug Overdoses
Authors: A. G. Rauws, J. van Noordwijk
Journal: BMJ (1972)

non-immune rosette formation are the facts that a relatively large proportion of lymphocytes of unimmuniz-d animais participate in the reaction, and that thymocytes are more active than non-thymic lymphocytes.The proportion of human lymphocytes which adhere to sheep red cells is often relatively large in non-immunized human subjects, and human fetal thymocytes are more active than peripheral lymphocytes.9The adherence of non-immunized human lymphocytes to sheep red cells is therefore likely to occur through non-immune rather than immune mechanisms.The adherence probably occurs through fortuitous cross- reactivity of sheep red cells with human lymphocyte surface receptors concerned with an autologous non-immune adherence.-Iam, etc.,
Private Power for the Public Good: A History of the Carnegie Foundation for the Advancement of Teaching
Authors: Dean M. Connors
Journal: JAMA (1984)

"The problem of our age is the proper administration of wealth, that the ties of brotherhood may still bind together the rich and the poor in harmonious relationship." So wrote that steel magnate and philanthropist extraordinaire, Andrew Carnegie, in an influential essay first published in 1889. The solution to the problem of maldistribution of capital according to Carnegie's "Gospel of Wealth," as it soon came to be known, was to accept the dichotomy of rich and poor as an inevitable consequence of progress and to promote unmitigated capitalism, coupled with unstinting philanthropy. Living his ideas, Carnegie was at one time considered the richest man in the world, but by the time of his death in 1919, he had given away most of his fortune. Aside from the well-known endowments to community libraries, which made the name of Carnegie a household word all over the United States, a substantial proportion of
Leukocyte gene expression signatures in antineutrophil cytoplasmic autoantibody and lupus glomerulonephritis
Authors: D.A. Alcorta, D.A. Barnes, M.A. Dooley, P. Sullivan, B. Jonas, Y. Liu, S. Lionaki, C.B. Reddy, H. Chin, A.A. Dempsey, J.C. Jennette, R.J. Falk
Journal: Kidney International (2007)
Magnification and Chromoscopy with the Acetic Acid Test
Authors: R. Lambert, J. F. Rey, R. Sankaranarayanan
Journal: Endoscopy (2003)

The secondary prevention of female genital neoplasia, and of digestive neoplasia in both sexes, is based on early detection at the preinvasive stage. In the absence of conspicuous alterations of the mucosa, highly sophisticated techniques (spectroscopy, optical coherence tomography) have been developed for the purpose; however, their high cost and complexity is not compatible with widespread use in everyday practice. A technology combining a high level of optical resolution with a magnification system provides a more accessible option.
Effect of Cigarette Smoking on Urinary Podocyte Excretion in Early Diabetic Nephropathy
Authors: Tsukasa Nakamura, Yasuhiro Kawagoe, Hikaru Koide
Journal: Diabetes Care (2003)

Smoking has been pinpointed as a factor causing progression of chronic nephropathies. It is worth noting that smoking increases urinary albumin concentration, even at albumin concentrations below that of microalbuminuria (1). There is growing evidence that smoking not only increases the risk of albuminuria but also the risk of renal functional deterioration. The frequency of nephropathy is progressively higher with increasing cigarette consumption. The available literature documents that smoking increases the risk of developing microalbuminuria, accelerates the rate of progression from microalbumunuria to manifest proteinuria, and accelerates the progression of renal failure (1). Chase et al. (2) reported that in a group of 359 young patients with type 1 diabetes, the prevalence of borderline and frankly elevated urinary albumin …
Hematopoietic Growth Factors and the Future of Therapeutic Research on Acute Myeloid Leukemia
Authors: Charles A. Schiffer
Journal: New England Journal of Medicine (2003)

Acute myeloid leukemia (AML) is a malignant disease resulting from acquired mutations that block the differentiation of primitive hematopoietic cells and thereby cause immature myeloid precursors to accumulate. The leukemia cells not only have a proliferative advantage, but also suppress the growth and maturation of normal blood cells, resulting in anemia, neutropenia, and thrombocytopenia. AML occurs in patients of all ages, and approximately 35 to 40 percent of younger patients can be cured with intensive chemotherapy. The results are much worse in patients who are older than 60 years of age: only 5 to 10 percent of such patients are . . .
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
Authors: Liufu Deng, Hua Liang, Meng Xu, Xuanming Yang, Byron Burnette, Ainhoa Arina, Xiao-Dong Li, Helena Mauceri, Michael Beckett, Thomas Darga, Xiaona Huang, Thomas F. Gajewski, Zhijian J. Chen, Yang-Xin Fu, Ralph R. Weichselbaum
Journal: Immunity (2014)
Dual-modal upconversion fluorescent/X-ray imaging using ligand-free hexagonal phase NaLuF4:Gd/Yb/Er nanorods for blood vessel visualization
Authors: Songjun Zeng, Haibo Wang, Wei Lu, Zhigao Yi, Ling Rao, Hongrong Liu, Jianhua Hao
Journal: Biomaterials (2014)
Discrepancies between Doppler and catheter gradients in aortic prosthetic valves in vitro. A manifestation of localized gradients and pressure recovery.
Authors: H Baumgartner, S Khan, M DeRobertis, L Czer, G Maurer
Journal: Circulation (1990)

To evaluate possible causes of discrepancy between Doppler and catheter gradients across prosthetic valves, five sizes (19-27 mm) of St. Jude and Hancock valves were studied in an aortic pulsatile flow model. Catheter gradients at multiple sites distal to the valve were compared with simultaneously obtained Doppler gradients. In the St. Jude valve, significant differences between Doppler and catheter gradients measured 30 mm downstream from the valve were found: Doppler gradients exceeded peak catheter gradients of 10 mm Hg or more by 81 +/- 35% (15 +/- 3.6 mm Hg), and mean catheter gradients by 71 +/- 11% (10.3 +/- 2.5 mm Hg). When the catheter was pulled back through the tunnel-like central orifice of the valve, high localized gradients at the valve plane and significant early pressure recovery were found. When the catheter was pulled back through the large side orifices, gradients at the same level were only 46 +/- 6% of the central orifice gradients (mean difference, 7.6 +/- 4.5 mm Hg). Doppler peak and mean gradients showed excellent agreement with the highest central orifice catheter gradients (mean difference, 1.0 +/- 3.1 and 0.9 +/- 1.5 mm Hg, respectively). A significantly better agreement between Doppler and catheter gradients at 30 mm was found for the Hancock valve, although Doppler peak and mean gradients were still slightly greater than catheter gradients. Doppler gradients exceeded catheter gradients by 18 +/- 10% (3.4 +/- 1.9 mm Hg) and 13 +/- 11% (2.1 +/- 0.9 mm Hg), respectively. When the catheter was pulled back through the valve, the highest gradients were found approximately 20 mm distal to the valve ring.(ABSTRACT TRUNCATED AT 250 WORDS)
Accuracy of Testing for Antibodies to Synthetic Gliadin–Related Peptides in Celiac Disease
Authors: Emilia Sugai, Horacio Vázquez, Fabio Nachman, María Laura Moreno, Roberto Mazure, Edgardo Smecuol, Sonia Niveloni, Ana Cabanne, Zulema Kogan, Juan C. Gómez
Journal: Clinical Gastroenterology and Hepatology (2006)
Nine Cases of Inguinal Colotomy for Malignant Disease of the Rectum: Recovery
Authors: H. Cripps
Journal: BMJ (1888)

COLOTOMY must Inot be considered in any way as a rival operation to that of excision in cases of rectal cancer.In a large number of instances excision is quite impracticable, and it is in such cases that the question of colotomy arises.The advantages of the operation lie partly in the relief it affords to symptoms, partly as a means of retarding the growth of the cancer.The pain caused by the growth itself varies greatly, and is more influenced by the position than by any other factor.When the growth is near the anal margin the pain is often intense, whereas, whlen higher up the bowel, there is comparative immunity.Sooner or later the
Estrogenic activity of natural and synthetic estrogens in human breast cancer cells in culture.
Authors: D T Zava, M Blen, G Duwe
Journal: Environmental Health Perspectives (1997)

We investigated the estrogenic activity of various environmental pollutants (xenobiotics), in particular the xenoestrogen o,p-DDT, and compared their effects with those of endogenous estrogens, phytoestrogens, and mycoestrogens on estrogen receptor binding capacity, induction of estrogen end products, and activation of cell proliferation in estrogen-sensitive human breast cancer cells in monolayer culture. We also quantified the levels of phytoestrogens in extracts of some common foods, herbs, and spices and in human saliva following consumption of a high phytoestrogen food source (soy milk) to compare phytoestrogen abundance and bioavailability relative to the reported xenoestrogen burden in humans. Results show that natural endogenous estrogens, phytoestrogens, mycoestrogens, and xenoestrogens bind estrogen receptor (ER) in intact cells, but demonstrate marked differences in their ability to induce end products of estrogen action and to regulate cell proliferation. All of the different classes of estrogens stimulated cell proliferation at concentrations that half-saturated ER, but only some classes were able to induce estrogen-regulated end products. Genistein, a common phytoestrogen found in soy foods, differed from the xenoestrogen DDT in its effects on cell proliferation and ability to induce estrogen-regulated end products. Moreover, we found that many of the foods, herbs, and spices commonly consumed by humans contain significant amounts of phytoestrogens, and consumption of soy milk, a phytoestrogen-rich food, markedly increases the levels of phytoestrogens in saliva. In conclusion, our in vitro results predict that a diet high in phytoestrogens would significantly reduce the binding of weak xenoestrogens to ER in target tissues in vivo.
Hydrazine Toxicity, Pyridoxine Therapy, and Peripheral Neuropathy
Authors: YADOLLAH HARATI
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 May 1986Hydrazine Toxicity, Pyridoxine Therapy, and Peripheral NeuropathyYADOLLAH HARATI, M.D., ENAYAT NIAKAN, M.D.YADOLLAH HARATI, M.D., ENAYAT NIAKAN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-5-728_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A patient who had hydrazine intoxication was successfully treated with megadoses of pyridoxine hydrochloride (vitamin B6) and subsequently developed a sensory polyneuropathy that resolved spontaneously.A 24-year-old man accidentally ingested a mouthful of hydrazine and immediately became confused, lethargic, and restless. On admission to a local hospital, a complete chemistry profile was normal. He remained confused, and his general condition remained stable until 3 days after admission, when results of liver function tests were noted to be elevated: aspartate aminotransferase (AST), 600 mU/mL (normal, 5 to 30); lactate dehydrogenase, 650 mU/mL (normal, 75 to 200); and total...References1. SCALESTIMBRELL MJ. Studies on hydrazine hepatoxicity: 1. pathological findings. J Toxicol Environ Health. 1982;10:941-5. CrossrefMedlineGoogle Scholar2. CORNISH H. The role of vitamin B in the toxicity of hydrazine. Ann NY Acad Sci. 1969;166:136-45. CrossrefMedlineGoogle Scholar3. HOLTZPALM PD. Pharmacologic aspects of vitamin B6. Pharmacol Rev. 1964;16:113-78. MedlineGoogle Scholar4. YARBOROUGHWOOD BJ. Isoniazid overdose treated with high-dose pyridoxine. Ann Emerg Med. 1983;12:303-5. CrossrefMedlineGoogle Scholar5. SCHAUMBURGKAPLANWINDEBANK HJA. Sensory neuropathy from pyridoxine abuse: a new megavitamin syndrome. N Engl J Med. 1983;309:445-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baylor College of Medicine Veterans Administration Medical Center Houston, TX 77030 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Toxicity, Pathophysiology, and Treatment of Acute Hydrazine Propellant Exposure: A Systematic ReviewAlkylpyridines and Miscellaneous Organic Nitrogen CompoundsIntoxications par les champignons : syndromes majeursPyridoxine in clinical toxicology: a reviewAlkylpyridines and Miscellaneous Organic Nitrogen CompoundsHydrazine, Cancer, the Internet, Isoniazid, and the LiverMartin Black, MD and Hamid Hussain, MDPyridoxine therapy in a patient with severe hydrazine sulfate toxicityHuman health perspective of environmental exposure to hydrazines: A reviewInteractions of Vitamin B6 (Pyridoxine) and Xenobiotics 1 May 1986Volume 104, Issue 5Page: 728-729KeywordsIntoxicationLactate dehydrogenaseLiver function testsPeripheral neuropathyPyridoxineSerum glutamic oxaloacetic transaminaseToxicity Issue Published: 1 May 1986 PDF DownloadLoading ...
Prognosis of hepatocellular carcinoma with diabetes mellitus after hepatic resection
Authors: Yasuharu Ikeda, Mitsuo Shimada, Hirofumi Hasegawa, Tomonobu Gion, Kiyoshi Kajiyama, Ken Shirabe, Katsuhiko Yanaga, Kenji Takenaka, Keizo Sugimachi
Journal: Hepatology (1998)

We evaluated the effect of diabetes mellitus on the prognosis of hepatocellular carcinoma after an elective hepatic resection. Of the 342 patients who underwent a hepatic resection between April 1985 and March 1995, 87 (25.4%) were diabetic. Postoperative morbidity was more common among diabetics than among nondiabetics (36.0% vs. 22.5%, P = .0239). The postoperative survival rate and the cancer-free survival rate were also better in patients without diabetes than in those with diabetes (P = .0333, P = .0149). The results of a multivariate analysis show diabetes mellitus to be an independent and prognostic indicator after a hepatic resection with hepatocellular carcinoma. According to the above findings, diabetes mellitus is thus considered to be a risk factor for prognosis after hepatic resection in patients with hepatocellular carcinoma.
Effect of Slow Pathway Ablation on Ventricular Rate During Atrial Fibrillation
Authors: Gerhard Kreiner, Gottfried Heinz, Peter Siostrzonek, Heinz David Gössinger
Journal: Circulation (1996)

Catheter ablation of the posteroseptal right atrium has been proposed for control of ventricular rate in patients with tachycardic atrial fibrillation (AF). However, the exact mechanism of rate control is unclear. Because the ablation site corresponds to the location of the slow pathway in patients with AV nodal reentry tachycardia (AVNRT), we investigated whether selective ablation of this posterior AV nodal input can provide a sufficient reduction in heart rate during AF.In 30 patients with AVNRT, conduction properties of the AV nodal pathways were determined before and after slow pathway ablation. AF was induced by burst pacing at baseline and after ablation, and the mean ventricular cycle length was determined. After slow pathway ablation, the mean ventricular cycle length during AF increased (449 +/- 98 versus 515 +/- 129 milliseconds, P < .01). At baseline, the mean ventricular cycle length correlated with the Wenckebach cycle length of both the slow (r = .90) and fast (r = .86) pathways. After ablation, the mean ventricular cycle length was extremely well determined by the Wenckebach cycle length of the fast pathway (r = .94). However, the slope of the regression line was significantly steeper compared with baseline (1.50 versus 0.77, P < .0001), illustrating that the reduction in ventricular rate was not as evident if the fast pathway had a short Wenckebach cycle length.Selective elimination of the slow pathway reduces ventricular rate during AF. However, in patients with a short Wenckebach cycle length of the anterior AV nodal input that causes tachycardic AF, this effect may be insufficient to provide adequate control of ventricular rate.
Quantification of P-32 Removed During Leukapheresis by Bremsstrahlung Counting
Authors: VICTOR N. EVDOKIMOFF, LEWIS R. WEINTRAUB
Journal: Clinical Nuclear Medicine (1984)

The activity of P-32 removed during leukapheresis of a patient previously administered P-32 for therapy of chronic myelogenous leukemia (CML) was determined. The bremsstrahlung produced by P-32 beta rays in the pheresis bags allowed the quantitation of radioactivity by well counting in a sodium iodide detector and by a gamma camera. Bremsstrahlung counting demonstrated that leukapheresis removes such a small amount of radioactivity that the therapeutic effect of a previously administered P-32 dose was still valid. Bremsstrahlung counting offers advantages to a Nuclear Medicine Department over the conventional use of a liquid scintillation counter to detect P-32 beta rays in that it is simpler and more readily available.