tbuckley/cabot-search huggingface dataset:
Response of Mononuclear Cells to <i>Borrelia burgdorferi</i>
Authors: LEONARD H. SIGAL
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 November 1985Response of Mononuclear Cells to Borrelia burgdorferiLEONARD H. SIGAL, M.D.LEONARD H. SIGAL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-5-808_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Only 2 years ago, the causative agent of Lyme disease was isolated (1) and now a diagnostic serologic test is available (2) to document the expanding geographic and clinical range of the disease. In their editorial, Duffy and Mertz (2) point out that coexisting babesia and borrelia infections make the question of the true etiopathogenesis unclear in the patient of Marcus and colleagues (3). Certainly, positive serologic tests document a previous encounter with B. burgdorferi, but they do not assure that current maladies are due to Lyme disease.We have tested mononuclear cells from patients with Lyme...References1. STEERE A, GRODZICKI R, and ARNOLD M. The spirochetal etiology of Lyme disease. N Engl J Med. 1983;308:733-40. CrossrefMedlineGoogle Scholar2. DUFFY J and MERTZ L. Serologic testing for Lyme disease [Editorial]. Ann Intern Med. 1985;103:458. LinkGoogle Scholar3. MARCUS L, STEERE A, DURAY P, ANDERSON A, and MAHONEY E. Fatal pancarditis in a patient with coexistent Lyme disease and babesiosis: demonstration of spirochetes in the myocardium. Ann Intern Med. 1985;103:374-6. LinkGoogle Scholar4. PACHNER A, SIGAL L, and STEERE A. Antigen-specific proliferation of CSF lymphocytes in Lyme disease. Neurology. (In press). Google Scholar5. SIGAL L, STEERE A, FREEMAN D, and DWYER J. Proliferative responses of mononuclear cells in Lyme disease: concentration of Borrelia burgdorferi reactive cells in joint fluid. Arthritis Rheum. (In press). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LEONARD H. SIGAL, M.D.Affiliations: State University of New York Upstate Medical Center Syracuse, NY 13210 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySummary of the first 100 patients seen at a Lyme disease referral centerLyme disease, 1988: Immunologic manifestations and possible immunopathogenetic mechanisms 1 November 1985Volume 103, Issue 5 Page: 808-809 Keywords Babesia Babesiosis Borrelia burgdorferi Cells Lyme disease ePublished: 1 December 2008 Issue Published: 1 November 1985 PDF downloadLoading ...
COMPARISON OF THE EFFICACY AND SAFETY OF EVEROLIMUS-, SIROLIMUS- AND ZOTAROLIMUS-ELUTING STENTS IN PATIENTS WITH ST-ELEVATION MYOCARDIAL INFARCTION
Authors: Jae-Sik Jang, Han Young Jin, Young-Wan Jo, Jeong-Sook Seo, Tae-Hyun Yang, Dae-Kyeong Kim, Dong-Soo Kim
Journal: Journal of the American College of Cardiology (2011)
THE MEMORIAL INSTITUTE FOR INFECTIOUS DISEASES.
Authors: FRANK BILLINGS
Journal: JAMA (1904)

The institute of which I desire to speak to you can not rank in wealth with the other institutions mentioned. It is small, modest in its beginning, and has for its location Chicago. The Memorial Institute for Infectious Diseases was organized January, 1902, by Mr. and Mrs. Harold F. McCormick, of Chicago, in memory of a son, who died of scarlet fever in January, 1901. At first their object was to study the cause of scarlet fever alone, but a few of their friends of the medical profession persuaded them that the conduct of a laboratory alone for the study of the cause of this disease was not the proper method of procedure, and the founders finally modified the plan by incorporating a hospital with it, and it was then named the Memorial Institute for Infectious Diseases. The institute has been wrongly named in some periodicals as the McCormick Institute
Fatal Eosinophilic Meningoencephalitis and Visceral Larva Migrans Caused by the Raccoon Ascarid<i>Baylisascaris procyonis</i>
Authors: Amy S. Fox, Kevin R. Kazacos, Nevenka S. Gould, Peter T. Heydemann, Chinnamma Thomas, Kenneth M. Boyer
Journal: New England Journal of Medicine (1985)

VISCERAL larva migrans is a subacute inflammatory disease characterized by hepatomegaly, eosinophilia, and hypergammaglobulinemia and due to the larval migration in human beings of nematodes normally parasitic in lower animals.1 , 2 Most cases in the United States occur in young children and are caused by the dog ascarid Toxocara canis.3 A fatal outcome and central nervous system involvement are rare.3 Ingestion of soil contaminated by infective eggs is the usual mode of acquisition. A specific parasite can be identified with certainty, however, only by morphometric analysis of larvae in tissue specimens, so the recent development of serodiagnostic tests for T. . . .
KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells
Authors: Sian M. Henson, Ornella Franzese, Richard Macaulay, Valentina Libri, Rita I. Azevedo, Sorena Kiani-Alikhan, Fiona J. Plunkett, Joanne E. Masters, Sarah Jackson, Stephen J. Griffiths, Hans-Peter Pircher, Maria V. D. Soares, Arne N. Akbar
Journal: Blood (2009)
Workshop summary: assessing exposure to environmental tobacco smoke in the workplace.
Authors: J M Samet
Journal: Environmental Health Perspectives (1999)

Environmental tobacco smoke (ETS) is a term now widely used to refer to the mixture of sidestream smoke and exhaled mainstream smoke that pollutes air in locations where tobacco smoking is taking place. A multidisciplinary workshop was convened to address key issues related to ETS exposure in the workplace in order to prepare the groundwork for a risk assessment of the hazard ETS poses to workers. Workshop participants concluded that substantial evidence was now available on worker exposure to ETS using both direct and indirect approaches to exposure assessment and that these data could be used to project distribution of exposures to ETS in the nation's workplaces. This summary of the discussions at the workshop is an overview of the suggested approach to exposure assessment.
The Pulmonary Echogram in the Study of Pulmonary Thromboembolism.
Authors: Claude R. Joyner
Journal: Annals of Internal Medicine (1969)

s1 May 1969The Pulmonary Echogram in the Study of Pulmonary Thromboembolism.Claude R. Joyner, M.D., F.A.C.P.Claude R. Joyner, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1098_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe normal pattern of reflection of ultrasound A by the lung is changed by pulmonary thromboembolism with or without infarction. Pulmonary echograms were obtained from 50 normal subjects and 200 patients to determine the reliability of the method in the detection of pulmonary thromboembolism. The echogram from the normal chest is a display fading 2 to 3 cm from the skin-transducer interface. A deeper echo return (4 to 8 cm) is recorded from areas over ischemic lung. A deep pattern was found in 138 patients suspected of having pulmonary thromboembolism. Absolute confirmation of pulmonary thromboembolism was obtained by necropsy or... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1098-1098KeywordsInfarctionLungsPulmonary embolismThoraxUltrasound imaging Issue Published: 1 May 1969 PDF downloadLoading ...
Early Prostate-Specific Antigen Relapse after Radical Retropubic Prostatectomy:Prediction on the Basis of Preoperative andPostoperative Tumor Characteristics
Authors: Markus Graefen, Joachim Noldus, Uwe Pichlmeier, Alexander Haese, Peter Hammerer, Salvador Fernandez, Stefan Conrad, Rolf-Peter Henke, Edith Huland, Hartwig Huland
Journal: European Urology (1999)
Relationships between Jenkins Activity Survey Scores and Responsivity of the Dopaminergic System in Psychosomatic Disorders
Authors: S. Sato, Y. Sugiyama, S. Okuse, N. Yashiro
Journal: Psychotherapy and Psychosomatics (1987)

First, the Jenkins Activity Survey (JAS) was administered to 150 healthy subjects and 127 psychosomatic patients. Next, the responsivity of the dopaminergic system of the hypothalamo-pituitary gland was measured in 81 of these psychosomatic patients by examining the effect of bromocriptine on plasma growth hormone levels. Subjects were classified as either responders or nonresponders based on their secretion patterns. Multidimensional scaling techniques successfully discriminated between healthy subjects, psychosomatic responders and psychosomatic nonresponders using the items of the JAS. Implications for treating nonresponder psychosomatics in Japan are discussed.
Advocacy and concerted action are needed to tackle rising rates of malnutrition
Authors: T. Richards
Journal: BMJ (2011)

National governments and international agencies need to mount a more vigorous and better coordinated response to improve food security and malnutrition, agreed a conference in Delhi held between 10 and 12 February on leveraging agriculture for improving nutrition and health.

Rising food prices and climate change are threatening progress towards the millennium development goals; not least the pledge to halve poverty and hunger by 2015. Advocacy was needed to increase awareness of the scale and adverse impact of malnutrition on health, productivity, and national economies, delegates agreed. Access to sufficient, adequately nutritious, and sustainably produced food should be seen as a basic human right, it was argued. 

The conference, organised by the International Food Policy Research Institute, attracted around 900 participants, predominantly from …
Effect of Awareness of a Randomized Controlled Trial on Use of Experimental Therapy
Authors: William F. Clark
Journal: JAMA (2003)

Use of experimental therapies during but outside of randomized controlled trials (RCTs) has not been studied.To determine whether initiation of an RCT leads to increased use of the experimental therapy outside the trial.Data on national apheresis use during 3 Canadian RCTs for multiple sclerosis (1986-1988), thrombotic thrombocytopenic purpura (1982-1988), and myeloma cast nephropathy (1998-2000) were obtained from 19 major medical centers in Canada. The multiple sclerosis and myeloma cast nephropathy trials had data on apheresis use for 3 years prior to and during the trials, which permitted a time-series analysis to determine the impact of the RCTs on the use of apheresis. The ongoing myeloma cast nephropathy trial provided data on the number of patients inside and outside of the RCTs in trial and nontrial centers. Initial and follow-up questionnaires were sent to 24 Canadian physicians in trial and nontrial centers to determine if they had noted an increase in apheresis activity during the trials and, if so, their explanation for it.Change in number of patients undergoing apheresis for thrombotic thrombocytopenic purpura, multiple sclerosis, and myeloma cast nephropathy prior to and during the respective RCTs compared with all patients undergoing apheresis during the same periods.During all 3 RCTs, there were large increases in use of apheresis. The majority of the increased use of apheresis was outside of the trials: for multiple sclerosis, 30 of 49 patients per year (61% of increase); thrombotic thrombocytopenic purpura, 49 of 56 patients per year (72% of increase); and myeloma cast nephropathy, 60 of 72 patients per year (57% of increase). The myeloma cast nephropathy study noted that this increase occurred in both nontrial and trial centers. Among questionnaire respondents (n = 22; 92% response rate), most physicians noted an increase in apheresis activity during the trials and attributed it to a "jumping-the-gun" phenomenon.During 3 Canadian RCTs, apheresis increased, but most of the increase occurred outside the trials. This behavior during an RCT, in the absence of clear efficacy, can be termed jumping the gun.
Serum Lipoprotein Abnormalities in Patients with Ischaemic Heart Disease: Comparisons with a Control Population
Authors: B. Lewis, A. Chait, C. M. O. Oakley, I. D. P. Wootton, D. M. Krikler, A. Onitiri, G. Sigurdsson, A. February
Journal: BMJ (1974)

The frequency and nature of abnormalities of serum lipoproteins have been studied, using quantitative techniques, in 143 patients with ischaemic heart disease (I.H.D.). Rigorous selection criteria were used. The findings were related to the distribution of lipoprotein concentrations in a carefully screened control population. Hyperlipoproteinaemia occurred in 55% of patients and in 11 out of 15 patients aged less than 40 years. Raised triglyceride and cholesterol concentrations in very low density lipoprotein were the most frequent abnormalities followed by raised cholesterol content of low density lipoprotein. In young patients high density lipoprotein levels were subnormal. Hyperlipoproteinaemia of W.H.O. types IIa, IIb, III, IV, and V all seemed to be over-represented in I.H.D. I.H.D. patients with type IIa, IIb, and IV abnormalities were all significantly younger than I.H.D. patients with normal lipoprotein levels.
Integrity of Active Components of Botanical Products Used in Complementary and Alternative Medicine
Authors: Catherine M. Stoney, Paul Coates, Josephine P. Briggs
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Present position of gastroenterology in The Netherlands.
Authors: G P van Berge Henegouwen
Journal: Gut (1994)

Present position of gastroenterology in the NetherlandsAlthough the subspecialty of gastroenterology was recognised as an independent specialty in the Netherlands as long ago as 1913, most of the gastroenterology services in this country are still provided by general internists.Some two million of the country's 15 million citizens experience digestive complaints annually.Thirteen per cent of the total mortality, 12% of the hospital admissions, and 17% of total hospital days result from diseases of the digestive system.Most complaints are handled by primary care or general practitioners who really have a gatekeeper function before patients go on to second or third line specialised centres.In general this system is to a great extent comparable with that in the United Kingdom.
Self-incompatibility system of Oenothera organensis for the detection of genetic effects at low radiation doses.
Authors: K S Ramulu, H Schibilla, P Dijkhuis
Journal: Environmental Health Perspectives (1981)

The self-incompatibility system of Oenothera organensis is used to analyze the frequency of S locus mutations induced by low doses (2.5-20 rad) of fast neutrons and x-rays. Th principles and methods of the screening system for detection of low dose effects have been presented. The results show that low doses induced significantly higher frequencies of seeds and seedlings than those produced spontaneously. The analyses of part of the progenies derived from the control and treated series suggested that they were due to revertible mutations. A modified in vitro method of culturing pollinated cut styles has been developed for rapid screening of compatible pollen tubes.
Enzyme replacement therapy with velaglucerase alfa in Gaucher disease: Results from a randomized, double‐blind, multinational, Phase 3 study
Authors: Derlis E. Gonzalez, Hadhami Ben Turkia, Elena A. Lukina, Isaac Kisinovsky, Marie‐Françoise Ben Dridi, Deborah Elstein, David Zahrieh, Eric Crombez, Kiran Bhirangi, Norman W. Barton, Ari Zimran
Journal: American Journal of Hematology (2012)

Type 1 Gaucher disease (GD1), resulting from glucocerebrosidase deficiency, leads to splenomegaly, hepatomegaly, anemia, thrombocytopenia, and bone involvement. Current standard treatment is enzyme replacement therapy. Velaglucerase alfa is an enzyme replacement product for GD1, with the same amino acid sequence as naturally occurring human glucocerebrosidase. This multinational, Phase 3 trial evaluated the efficacy and safety of two doses of velaglucerase alfa in 25 treatment‐naïve, anemic patients with GD1 (4–62 years of age), randomized to intravenous velaglucerase alfa 60 U/kg ( n =12) or 45 U/kg body weight ( n =13) every other week for 12 months. The primary endpoint was change from baseline in hemoglobin concentration in the 60 U/kg arm. At 12 months, mean hemoglobin concentrations increased from baseline [60 U/kg: +23.3%; +2.43 g/dL ( P &lt;0.001); 45 U/kg: +23.8%; +2.44 g/dL ( P &lt;0.001)], as did mean platelet counts [60 U/kg: +65.9%; +50.9 × 10 9 /L ( P =0.002); 45 U/kg: +66.4%; +40.9 × 10 9 /L( P =0.01)]. Mean splenic volume decreased from baseline [60 U/kg: −50.4%, from 14.0 to 5.8 multiples of normal (MN) ( P =0.003); 45 U/kg: −39.9%, from 14.5 to 9.5 MN ( P =0.009)]. No drug‐related serious adverse events or withdrawals were observed. One patient developed antibodies. Velaglucerase alfa was generally well tolerated and effective for adults and children with GD1 in this study. All disease‐specific parameters measured demonstrated clinically meaningful improvements after 12 months. Am. J. Hematol. 88:166–171, 2013. © 2012 Wiley Periodicals, Inc.
<i>Spirillum serpens</i>Meningitis
Authors: Charles E. Edwards, Richard Kraus
Journal: New England Journal of Medicine (1960)

THE causative organism of the disease known as rat-bite fever or sodoku was identified by Futaki and his associates1 in 1916. Some fourteen years later Robertson2 demonstrated this organism to be identical with the previously discovered Spirillum minus. Up to the present time, however, no other member of the genus spirillum has been considered pathogenic for man although disease in other vertebrates has been reported.3 In the past year, however, a case was encountered that, from the bacteriologic studies, indicates the existence of an infection in man due to a member of the genus other than S. minus. . . .
Abstract 5383: Inhibition of MCL-1 in mammary and CNS tumor cells promotes cell death <i>in vitro</i> and <i>in vivo</i>
Authors: Hossein A. Hamed, Clint Mitchell, Paul Dent, Adly Yacoub, Gary Tye, Mary Danielle Bareford
Journal: Cancer Research (2011)

Abstract Treatment of cells with the BH3 domain/MCL-1 inhibitor obatoclax enhanced the lethality of lapatinib in a synergistic fashion in multiple tumor cell types, including ER+; HER2+; triple negative breast cancer cells and glioblastoma and medulloblastoma cells. Knock out of MCL-1 and BCL-XL enhanced lapatinib toxicity to a similar extent as obatoclax and suppressed the ability of obatoclax to promote lapatinib lethality. Pre-treatment of cells with lapatinib or with obatoclax enhanced basal levels of BAX and BAK activity and further enhanced drug combination toxicity. In vitro, treatment of breast cancer cells with obatoclax and lapatinib enhanced the toxicity of ionizing radiation. In vivo tumor growth data in xenograft and syngeneic model systems of breast cancer confirmed our in vitro findings. Lapatinib and obatoclax interacted to suppress mammary tumor growth in vivo without causing toxicity to multiple normal tissues including brain, heart, lungs, liver or kidneys. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5383. doi:10.1158/1538-7445.AM2011-5383
Successful Outcome of Pregnancy in Women with Hypothyroidism
Authors: MARTIN MONTORO
Journal: Annals of Internal Medicine (1981)

Published data on the influence of hypothyroidism on fertility, gestation, and the offspring are controversial. We studied nine hypothyroid women during 11 pregnancies. Mean serum values for thyroxine, triiodothyronine (T3), resin T3 uptake ratio, and thyroid-stimulating hormone were 2.3 μg/dL, 82 ng/dL, 0.64, and 105 mU/mL, respectively. Four patients had iatrogenic hypothyroidism (three remote thyroidectomy, one remote 131I therapy), two Hashimoto's thyroiditis, and three idiopathic primary hypothyroidism. Seven patients first presented untreated after the 24th week of gestation. Two patients needed cesarean section; seven delivered vaginally. There was one stillborn infant in the only patient with pre-eclampsia. Another infant had Down's syndrome and an ostium primum defect (mother's age, 41 years). The remaining nine infants were normal at birth. All placentas were normal. Follow-up in seven infants up to 2.7 years showed normal thyroid function and somatic development. Infants of hypothyroid mothers may be normal because their hypothalamic-pituitary thyroid axis develops independently from the mother.
STATISTICAL STUDIES OF THE NATURE OF THE INFECTIOUS UNIT OF VACCINE VIRUS
Authors: Robert F. Parker
Journal: The Journal of Experimental Medicine (1938)

A method has been described by which it is possible to estimate the number of particles of vaccine virus which are required to cause infection in the rabbit skin. The method consists essentially in performing a series of intradermal inoculations in rabbits of suitably diluted virus suspensions. The percentage of inoculations at each dilution giving rise to lesions is observed, and the data are subjected to appropriate statistical analysis. Several strains of vaccine virus, differing in their characteristics, have been studied with the following results. Infection with the New York City Board of Health virus appears to follow the injection of a single particle of virus. The same is true for the strain derived from it but cultured in a chick embryo-Tyrode solution medium for a prolonged period. This strain, as has been noted, has largely lost its ability to cause extensive necrosis in the rabbit skin, and causes generalized infection only exceptionally. From the results here reported, it appears that other factors are responsible for the altered character of the lesion than the ability of the virus to establish a foothold in the animal organism. In this respect the cultured appears to be the equal of the original passage virus. Similarly the Noguchi strain of virus is apparently capable of infecting, if a single virus particle is properly introduced.
Bone Scintigraphic Appearances of Massive Bone Allograft and Local Recurrence of Sarcoma
Authors: IAIN E.T. STEWART, IAN DAVEY, SHEKHAR KUMTA, CON METREWELI, PING CHUNG LEUNG
Journal: Clinical Nuclear Medicine (1995)

A 12-year-old boy underwent excision of the right distal femur and allograft insertion for right distal femoral osteogenic sarcoma. Eighteen months after allograft placement subcutaneous nodules developed around the right knee. Radionuclide imaging of massive bone allograft and sarcoma recurrence are presented.