tbuckley/cabot-search huggingface dataset:
Abstract 2847: TagSNPs in the podocalyxin (<i>PODXL</i>) gene are associated with prostate cancer risk
Authors: Cathryn H. Bock, Ann G. Schwartz, Albert M. Levin, Julie J. Ruterbusch, Rick A. Kittles, Benjamin A. Rybicki
Journal: Cancer Research (2010)

Abstract Previous gene mapping efforts, including a recent admixture mapping study, concluded that there is likely at least one prostate cancer susceptibility locus on 7q32. Podocalyxin (PODXL) is the strongest candidate gene in this region, particularly for risk of aggressive disease (Casey et al. Human Molecular Genetics, 5: 735-741, 2006). Therefore, we examined 34 tagSNPs in the PODXL gene in relation to prostate cancer risk and aggressiveness in a sample of unrelated cases (n=626) and controls (n=239) from metropolitan Detroit, MI. Men were recruited from Henry Ford Health System; cases were diagnosed with prostate cancer between 2001 and 2004, and controls were frequency matched to cases on 5 year age groups and race. Logistic regression models were adjusted for family history of prostate cancer, race, age, and ancestry where appropriate. Carrying at least one copy of the variant A allele in SNP rs3212299 was associated with a decrease in prostate cancer risk (OR=0.60, 95% CI: 0.41, 0.90). Having at least on copy of the C allele in SNP rs11773254 was associated with a 70% increased risk of prostate cancer (OR = 1.70, 95% CI: 1.13, 2.58). The G allele of rs1733874 was marginally protective in the entire sample (OR=0.74, 95% CI: 0.49, 1.02). These risk estimates did not appreciably vary after stratifying by race [African American (AA), European American (EA)], age (&amp;lt; age 62, &amp;gt; age 62), or prostate cancer aggressiveness (Gleason sum 3+4 or lower, Gleason sum 4+3 or higher). In addition, a protective effect of the C allele in SNP rs3800684 was observed in AA men (OR=0.56, 95% CI: 0.35, 0.90) but not in EA men (OR=1.38, 95% CI: 0.92, 2.09), and there was a statistically significant interaction between race and genotype at this marker (p=0.005). After stratifying by median age, the A allele of SNP rs10224884 was marginally associated with increased prostate cancer risk in the older age group (OR=1.44, 95% CI : 0.92, 2.27), but not the younger age group (OR=0.69, 95% CI: 0.42, 1.13), and the interaction between age group and genotype was statistically significant (0.03). Overall, we conclude that SNPs in the PODXL gene are associated with prostate cancer risk, but not prostate cancer aggressiveness, and that some of these variants may have race- and age-specific effects. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2847.
Response gene to complement 32 (RGC-32) expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4
Authors: Peng Zhao, Daiqing Gao, Qingjie Wang, Bingfeng Song, Qianqian Shao, Jintang Sun, Chunyan Ji, Xingang Li, Peng Li, Xun Qu
Journal: Cellular and Molecular Immunology (2014)
Hypertrichosis and hyperpigmentation with systemic psoralen treatment
Authors: Gurmohan Singh, Sardari Lal
Journal: British Journal of Dermatology (1967)

Journal Article Hypertrichosis and hyperpigmentation with systemic psoralen treatment Get access Gurmohan Singh, Gurmohan Singh 22, Medical Enclave, College of Medical Sciences, Banaras Hindu University, Varanasi, 5, India Search for other works by this author on: Oxford Academic Google Scholar Sardari Lal Sardari Lal 22, Medical Enclave, College of Medical Sciences, Banaras Hindu University, Varanasi, 5, India Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 79, Issue 8-9, 1 August 1967, Pages 501–503, https://doi.org/10.1111/j.1365-2133.1967.tb11541.x Published: 01 August 1967
Predicting psychopaths' violent behaviour is no better than chance, study finds
Authors: I. Torjesen
Journal: BMJ (2013)

Risk assessment tools used to predict the chances of a prisoner’s reoffending if they are released are “useless” for people with psychopathic personalities and antisocial personality disorders, a study published online in the British Journal of Psychiatry has found.1

Around 40% of people convicted of violent crimes reoffend within two years when released by the criminal justice system, and among those held in secure mental health facilities the proportion is around 4-7%.

Parole boards rely heavily on risk assessment tools when deciding whether a prisoner would pose a future risk to society if released, and in some US states the tools influence decisions on whether a convicted criminal should receive the death penalty.

However, the study’s lead researcher, …
Subclavian arterioplasty for the ipsilateral subclavian-to-pulmonary artery shunt.
Authors: H Laks, W Williams, G Trusler, A Castaneda
Journal: Circulation (1979)

A new technique is described to avoid kinking and improve flow in the ipsilateral subclavian-to-pulmonary artery shunt. Experience with this procedure is reviewed in 35 infants and children with a variety of cyanotic congenital heart disease, including 10 with tricuspid atresia. Of these, 17 had had previous shunts: a Waterston shunt in six, a Glenn shunt in six, and a contralateral Blalock-Taussig shunt in five. The mean age was 5.6 years (range, 1 day to 16 years), and the mean follow-up was 24 months (range, 11 months to 4.5 years). There were no early deaths (less than 30 days), but there were two late deaths. There were three shunt failures at 2 weeks, 1 month, and 10 months; two of the failures were in infants aged 1 day and 4 days at operation. There were no late shunt failures. The patency by the life table method was 91.4% at 6 months, 88.5% at 1 year, with no further drop-off. It is concluded that subclavian arterioplasty can be performed safely and offers improved shunt patency in comparing to the ipsilateral Blalock-Taussig shunt.
Scottish GPs prescribe more now but spend less
Authors: B. Christie
Journal: BMJ (2013)

<h3>Abstract</h3> Few studies have used psychological autopsies to evaluate large and diverse populations on transdiagnostically relevant variables such as personality, temperament, and trauma exposure, rather they tend to focus on specific psychiatric disorders or manner of death. We therefore developed the <i>UT Health Psychological Autopsy Interview Schedule</i> (UTH-PAIS). The measure is described, and our results show that that the PAIS diagnoses and dimensions can be reliably assessed. Furthermore, we were able to show that our sample of donated brains overall matches the demographic characteristics of larger pool of individuals receiving a medical autopsy. In the Discussion we review the strengths and potential limitations of the study and outline in which context the PAIS will prove to be useful.
TNF-ALPHA AND IL-6 MOBILIZE BONE MARROW CELLS TO VASCULAR WALL, RESULTING IN NEOINTIMAL FORMATION THROUGH ITS INFLAMMATORY EFFECTS
Authors: Makoto Shoji, Hiroshi Suzuki, Yuya Yokota, Yasutoshi Ohmori, Takatoshi Sato, Shinji Koba, Eiichi Geshi, Takashi Katagiri, Youichi Kobayashi
Journal: Journal of the American College of Cardiology (2011)
Severe Methyprylon Intoxication Treated by Hemodialysis
Authors: Jorge M. Mandelbaum
Journal: JAMA (1971)

In a case of severe intoxication following the ingestion of 22.5 gm of methyprylon, 20% of the ingested dose was removed by gastric lavage. Rapid clinical improvement occurred with hemodialysis, during which the blood level of methyprylon fell from 20.9 to 3.0 mg/100 ml. An estimated minimum 20% of the absorbed dose was recovered in the hemodialysate, while less than 5% appeared in the urine during the first 24 hours of forced diuresis.
The effect of intramural delivery of polymeric nanoparticles loaded with the antiproliferative 2-aminochromone U-86983 on neointimal hyperplasia development in balloon-injured porcine coronary arteries
Authors: William R. Humphrey, Laurence A. Erickson, Carol A. Simmons, Jennifer L. Northrup, Donn G. Wishka, Joel Morris, Vinod Labhasetwar, Cunxian Song, Robert J. Levy, Ronald J. Shebuski
Journal: Advanced Drug Delivery Reviews (1997)
Low birth weight is associated with chronic kidney disease only in men
Authors: S. Li, S.-C. Chen, M. Shlipak, G. Bakris, P.A. McCullough, J. Sowers, L. Stevens, C. Jurkovitz, S. McFarlane, K. Norris, J. Vassalotti, M.J. Klag, W.W. Brown, A. Narva, D. Calhoun, B. Johnson, C. Obialo, A. Whaley-Connell, B. Becker, A.J. Collins
Journal: Kidney International (2007)
Hyperbaric Oxygen Therapy in Chronic Hemorrhagic Shock
Authors: Robert S. Amonic
Journal: JAMA (1969)

A Jehovah's Witness patient bled massively per rectum, but refused blood transfusion. A bleeding gastric leiomyoma was excised at eventual operation. His hemoglobin value fell to 2.2 gm/100 cc and on the third postoperative day he showed evidence of severe cerebral and myocardial ischemia and congestive heart failure developed. Hyperbaric oxygen therapy caused a reversal of all signs and symptoms of hypoxia, and the patient recovered. Blood taken from a subject breathing air at 1 atmosphere pressure has 0.3 vol% of oxygen dissolved in plasma; if the subject breathes 100% oxygen at 2 atmospheres absolute pressure, the amount of oxygen in physical solution in plasma is 4 vol%. In a patient with greatly diminished hemoglobin value, this increase in plasma oxygen may be adequate to sustain life.
Recovery of Detached Catheter Fragments
Authors: Joseph L. Curry
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Falchuk et al (<b>210:</b>1594, 1969) described a snare-type of instrument for the nonsurgical removal of detached catheter fragments from within the cardiovascular system. The instrument consists of a folded guide wire which is passed through a catheter. The folded guide wire then protrudes from the end of the catheter and is used as a snare to retrieve catheter fragments. Such an instrument has been commercially available since October 1968, having been fabricated for me by Cook, Inc., Bloomington, Ind. This was the basis of an article describing this instrument and its usage.<sup>1</sup>The concept seems to have some merit, and I know of several instances where broken catheter fragments have been successfully removed from the right side of the heart, using the instrument described.<sup>2</sup> This concept is so fundamental, it is difficult to believe that many angiographers have not used some modification of it.
Most women with acne have polycystic ovaries
Authors: C.B. BUNKER, JULIA A. NEWTON, JULIE KILBORN, ANITA PATEL, G.S. CONWAY, H.S. JACOBS, M.W. GREAVES, PAULINE M. DOWD
Journal: British Journal of Dermatology (1989)

Out of 98 female referrals with acne vulgaris it was possible to define ovarian morphology by high resolution ultrasound imaging of the pelvis in 82 (84%). Sixty-eight (83%) were shown to have polycystic ovaries, compared with 19% in a control group without acne. The presence of polycystic ovaries in the acne patients did not correlate with acne severity, infertility, menstrual disturbance, hirsutes, or biochemical endocrinological abnormalities.
Strategies for Improving Surgical Quality — Should Payers Reward Excellence or Effort?
Authors: Nancy J.O. Birkmeyer, John D. Birkmeyer
Journal: New England Journal of Medicine (2006)

Payers are pursuing three strategies to improve surgical care. The centers-of-excellence approach steers patients to doctors and hospitals with low surgical morbidity and mortality. Pay for performance offers financial incentives to improve processes, such as preoperative administration of antibiotics. In pay for participation, payers provide resources to allow hospitals and surgeons to collaborate to improve the quality of care. The authors argue that the pay-for-participation approach offers the greatest potential for improving surgical quality.
TCT-317 Impact of Glycemic Control on Cardiovascular Outcomes in Secondary Prevention of Diabetic Patients after a First Coronary Event. Insights from an international registry including 1,036 patients.
Authors: Olivier Varenne, Talib Majwal, Philippe Commeau, Arif A. Al-Nooryani, Patrick Henry, Peter Sinnaeve, Waqar Ahmed
Journal: Journal of the American College of Cardiology (2013)
Severe Measles in Immunocompromised Patients
Authors: Leonard J. Kaplan
Journal: JAMA (1992)

<h3>Objectives.</h3> —To describe the severity of measles in immunocompromised hosts and to assess preventive and therapeutic modalities. <h3>Data Sources.</h3> —Patients admitted to two academic medical centers between September 1989 and December 1990 and English language references obtained by MEDLINE from 1963 to 1991. Bibliographies were used to identify reports prior to 1963. <h3>Study Selection.</h3> —We identified nine immunocompromised patients with measles. Further analysis was based on 35 patients from two cohort studies of measles in oncology patients and 24 reported cases of measles in human immunodeficiency virus (HIV)—infected patients. <h3>Data Extraction.</h3> —Clinical data are presented from the nine patients we treated. Information concerning measles complications, presence of rash, use of prophylactic immunoglobulin, and therapeutic measures was extracted from the literature. <h3>Data Synthesis.</h3> —Of our nine patients, eight developed severe complications and two died. Two patients had no rash. In combining our patients with those from the literature, severe complications occurred in about 80%. The case fatality rate for severe measles was about 70% for oncology patients and about 40% for HIV-infected patients. Rash was absent in about 30%. The efficacy of prophylactic or therapeutic measures could not be assessed due to the small number of patients. However, we observed a rapid defervescence following administration of ribavirin. Vaccinated, HIV-infected patients had a lower mortality rate than those not previously vaccinated (<i>P</i>=.06). <h3>Conclusions.</h3> —Measles is a severe illness in immunocompromised patients, and the absence of rash is frequent. While treatment is supportive, ribavirin requires further study. Measles vaccine may be efficacious in HIV-infected patients. Vaccination of oncology patients should be reassessed. (<i>JAMA</i>. 1992;267:1237-1241)
Points: Oxygen as a driving gas for nebulisers: safe or dangerous?
Authors: S Coltart, B D W Harrison
Journal: BMJ (1984)

which is more likely to be detrusor inhibition mediated at the level of the sacral cord "bladder centre."Further research is indicated to assess the interaction of both limbs of the autonomic nervous system with the various peptidergic systems in the control of lower urinary tract function to evaluate their future therapeutic importance.
Effects of Prenatal Exposure to Coal-Burning Pollutants on Children’s Development in China
Authors: Deliang Tang, Tin-yu Li, Jason J. Liu, Zhi-jun Zhou, Tao Yuan, Yu-hui Chen, Virginia A. Rauh, Jiang Xie, Frederica Perera
Journal: Environmental Health Perspectives (2008)

Environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs), lead, and mercury are released by combustion of coal and other fossil fuels.In the present study we evaluated the association between prenatal exposure to these pollutants and child development measured by the Gesell Developmental Schedules at 2 years of age.The study was conducted in Tongliang, Chongqing, China, where a seasonally operated coal-fired power plant was the major source of ambient PAHs and also contributed lead and mercury to the air. In a cohort of nonsmoking women and their newborns enrolled between March 2002 and June 2002, we measured levels of PAH-DNA adducts, lead, and mercury in umbilical cord blood. PAH-DNA adducts (specifically benzo[a]pyrene adducts) provided a biologically relevant measure of PAH exposure. We also obtained developmental quotients (DQs) in motor, adaptive, language, and social areas.Decrements in one or more DQs were significantly associated with cord blood levels of PAH-DNA adducts and lead, but not mercury. Increased adduct levels were associated with decreased motor area DQ (p = 0.043), language area DQ (p = 0.059), and average DQ (p = 0.047) after adjusting for cord lead level, environmental tobacco smoke, sex, gestational age, and maternal education. In the same model, high cord blood lead level was significantly associated with decreased social area DQ (p = 0.009) and average DQ (p = 0.038).The findings indicate that exposure to pollutants from the power plant adversely affected the development of children living in Tongliang; these findings have implications for environmental health policy.
Restructuring emergency surgery staffing improves outcomes and reduces costs
Authors: B. Roehr
Journal: BMJ (2012)

Integrating acute care surgery, by combining trauma and emergency general surgery, resulted in better patient outcomes and saved money for the two most common emergency procedures, appendicitis and cholecystitis, according to a study in the Journal of the American College of Surgeons .1

The study retrospectively analysed records for the 12 month periods preceding and following the …
Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Subcutaneous (SC) Cinryze® (C1 inhibitor (C1 INH) with Recombinant Human Hyaluronidase (rHuPH20) in Subjects with Hereditary Angioedema (HAE)
Authors: J. Schranz, R. Levy, W. Lumry, M. Manning, J. Jacobs, S.S. Dychter, M.J. LaBarre, A. Phillips, S. Gelone, C. Broom
Journal: Journal of Allergy and Clinical Immunology (2012)

HAE manifests as recurrent painful, disabling, and sometimes fatal swelling attacks. CINRYZE administered by the IV route replaces deficient and/or dysfunctional C1 INH and has proven efficacy and safety for both acute treatment and prevention. In order to provide broader options for patients to control disease, the potential enhancement of CINRYZE SC dispersion and absorption when co-administered with rHuPH20 was assessed in HAE patients.
Impairment of natural killer functions by interleukin 6 increases lymphoblastoid cell tumorigenicity in athymic mice.
Authors: J Tanner, G Tosato
Journal: Journal of Clinical Investigation (1991)

Expression of the human IL-6 gene in EBV-immortalized normal human B lymphocytes following retroviral-mediated transduction rendered these cells highly tumorigenic in athymic mice. The tumors were lymphomas composed of the originally inoculated human lymphoblastoid cells. Co-injection of IL-6 expressing EBV-immortalized cells with IL-6 nonexpressing control cells resulted in increased tumorigenicity of the IL-6 nonexpressing cells. The lymphoblastoid cells expressing IL-6 were indistinguishable from parental cell lines in morphology and in a variety of cell surface characteristics, and did not exhibit growth advantage over parental cell lines in vitro, such that increased tumorigenicity is unlikely to depend upon a direct oncogenic effect of IL-6 on the B cells. Rather, at high concentrations, IL-6 markedly inhibits human lymphoblastoid cell killing by IL-2-activated murine splenocytes in vitro, suggesting that IL-6-related tumorigenicity might depend upon IL-6 inhibiting cytotoxicity at the tumor site. Thus, production of IL-6 by tumor cells that results in natural killer cell dysfunctions illustrates a novel mechanism of tumor cell escape from immune surveillance.
Cardiopulmonary Arrest
Authors: EDWARD BASS
Journal: Annals of Internal Medicine (1985)

Cardiopulmonary arrest is a test of the brain's tolerance to global ischemia. New insights into the pathophysiology of global ischemia have led to the potential use of early prophylactic anticonvulsants, hypothermia, barbiturate coma, glucose manipulations, calcium-blocking agents, and hemodilution. A wide spectrum of neurologic sequelae may follow global ischemia, ranging from brain death, vegetative states, and impairment of higher intellectual function to syndromes of amnesia and cortical blindness, post-anoxic myoclonus, delayed leukoencephalopathy, and spinal stroke. The distinctive features of these sequelae and their pathophysiologic aspects are discussed. Special attention is given to brain death and prognostication.
The expression of low molecular weight keratins in basal cell carcinoma
Authors: Irene M. Leigh, P.E. Purkis, E.B. Lane
Journal: British Journal of Dermatology (1985)

Journal Article The expression of low molecular weight keratins in basal cell carcinoma Get access Irene M. Leigh, Irene M. Leigh Experimental Dermatology Laboratory, London Hospital, London Ei Search for other works by this author on: Oxford Academic Google Scholar P.E. Purkis, P.E. Purkis Experimental Dermatology Laboratory, London Hospital, London Ei Search for other works by this author on: Oxford Academic Google Scholar E.B. Lane E.B. Lane Imperial Cancer Research Eund, Lincolns Inn Eietd, London WC2 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Pages 39–40, https://doi.org/10.1111/j.1365-2133.1985.tb13005.x Published: 01 July 1985
Quantity, not quality, of antibody response decreased in the elderly
Authors: Bonnie B. Blomberg, Daniela Frasca
Journal: Journal of Clinical Investigation (2011)

The burden of disease during seasonal influenza epidemics is felt most keenly among the very young and the elderly. Although vaccination effectively protects children and young adults against infection, it has limited efficacy in elderly individuals. This has been linked to a reduced ability to induce a robust serum antibody response. In this issue of the JCI, Sasaki et al. identify some of the cellular and molecular deficits that underlie the reduced serum antibody response induced by influenza vaccination in elderly individuals. Importantly, they show that it is the quantity of the response, and not its quality, that needs to be improved if we are to enhance the success of influenza vaccination in this vulnerable population.
Increased blood flow inhibits neointimal hyperplasia in endothelialized vascular grafts.
Authors: T R Kohler, T R Kirkman, L W Kraiss, B K Zierler, A W Clowes
Journal: Circulation Research (1991)

Intimal hyperplasia is a primary cause of failure after vascular reconstruction and may be affected by blood flow. We have studied the effects of increased blood flow on intimal hyperplasia in porous polytetrafluoroethylene grafts implanted in baboons. These grafts develop an endothelial lining by 2 weeks and neointimal thickening due to proliferation of underlying smooth muscle cells by 1 month. Creation of a distal arteriovenous fistula increased flow (from 230 +/- 35 to 785 +/- 101 ml/min, p less than 0.001) and mean shear (from 26 +/- 4 to 78 +/- 10 dynes/cm2, p less than 0.001) without causing a drop in pressure across the grafts. Fistula flow did not alter the pattern of endothelial coverage but did cause a marked reduction in the cross-sectional area of the neointima (from 2.60 +/- 0.52 to 0.42 +/- 0.07 mm2 at 3 months, p less than 0.01). Detailed morphometric analysis revealed an equivalent percentage decrease in smooth muscle cells and matrix content, suggesting that the primary effect of increased flow was to reduce smooth muscle cell number without affecting the amount of matrix produced by individual cells. The neointima remained sensitive to changes in flow at late times; ligation of the fistula after 2 months resulted in a rapid increase in neointimal thickness (from 0.60 +/- 0.03 mm2 after 2 months of fistula flow to 3.88 +/- 0.55 mm2 1 month after ligation of fistula, p less than 0.01). These results support the hypothesis that changes in blood flow affect the structure of diseased as well as normal vessels.
Ligand-independent FLT3 activation does not cooperate with MLL-AF4 to immortalize/transform cord blood CD34+ cells
Authors: R Montes, V Ayllón, C Prieto, A Bursen, C Prelle, D Romero-Moya, P J Real, O Navarro-Montero, C Chillón, R Marschalek, C Bueno, P Menendez
Journal: Leukemia (2013)
Neuronal cell patterning on a multi-electrode array for a network analysis platform
Authors: Masaaki Suzuki, Koji Ikeda, Munehiro Yamaguchi, Suguru N. Kudoh, Keiko Yokoyama, Ryota Satoh, Daisuke Ito, Masafumi Nagayama, Tsutomu Uchida, Kazutoshi Gohara
Journal: Biomaterials (2013)