tbuckley/cabot-search huggingface dataset:
Removal of the Normal Appendix When Exposed.
Authors: Robert T. Morris
Journal: JAMA (1904)

New York City, June 14, 1904. <h3>To the Editor:</h3> —In the discussion at the Atlantic City session on the removal of normal appendices in the course of other work, I opposed the idea on three points: Removal of the appendix delays the other operation, adds a little to the danger, and, if the idea is taught by competent men, it will be carried out by those who will manage to get a death rate out of it. Immediately after the meeting I joined a group of physicians who expressed surprise at my stand, and who said that they were under the impression that I favored the removal of normal appendices anyway, as a prophylactic measure to be applied generally. As with other surgeons, a good many stories about me and my work "go the rounds," and many of them have a basis of fact. I would not correct any that
Abdominal Wall Mass
Authors: Kathryn Cameron, Krista Bannon, Vijay Mittal
Journal: JAMA Surgery (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Impaired Natriuretic and Renal Endocrine Response to Acute Volume Expansion in Pre-Clinical Systolic and Diastolic Dysfunction
Authors: Paul M. McKie, John A. Schirger, Lisa C. Costello-Boerrigter, Sherry L. Benike, Lynn K. Harstad, Kent R. Bailey, David O. Hodge, Margaret M. Redfield, Robert D. Simari, John C. Burnett, Horng H. Chen
Journal: Journal of the American College of Cardiology (2011)
The antipruritic effect of a sedative and a non-sedative antihistamine in atopic dermatitis
Authors: C-F. WAHLGREN, O. HAGERMARK, R. BERGSTROM
Journal: British Journal of Dermatology (1990)

A double‐blind, randomized, cross‐over study was carried out on the effect of a sedative and a non‐sedative antihistamine on 25 adults with atopic dermatitis. Intensity of itch was recorded using a computerized method for self‐assessment (Pain‐Track®) and using conventional visual analogue scales. The antipruritic effect of 3 days of treatment with the non‐sedative H, antagonist terfenadine (60 mg b.i.d.) and with the sedative antihistamine, clemastine (2 mg b.i.d.) did not differ from that found with the placebo. Our findings support the view that histamine is not of importance in the pathogenesis of itch in atopic dermatitis.
Aortic Insufficiency With Mild Ankylosing Spondylitis in Black Men
Authors: Walter Henry Eversmeyer
Journal: JAMA (1978)

Two black male patients with aortic insufficiency were later found to have mild, asymptomatic ankylosing spondylitis, evident from roentgenograms and from the presence of HLA-B27 antigen. The two cases emphasize that even "subclinical" ankylosing spondylitis may have aortic insufficiency, and that the uncommon occurrence of ankylosing spondylitis in black patients may also be associated with this extra-articular manifestation. (<i>JAMA</i>240:2652-2653, 1978)
Long-Term Results of a Phase II Trial of Induction Paclitaxel-Carboplatin Followed by Concurrent Radiation Therapy and Weekly Paclitaxel and Consolidation Paclitaxel-Carboplatin in Stage III Non-small Cell Lung Cancer
Authors: Francesc Casas, Núria Viñolas, Ferran Ferrer, Carles Agustí, Marcelo Sanchez, Josep Maria Gimferrer, Francisco Lomeña, Marc Campayo, Branislav Jeremic
Journal: Journal of Thoracic Oncology (2010)
Criteria for Waiver of Informed Consent for Quality Improvement Research—Reply
Authors: Mark J. Pletcher, Bernard Lo, Deborah Grady
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Hyperbaric oxygen in carbon monoxide poisoning.
Authors: J. Pearce
Journal: BMJ (1969)

JORA 53 intense loneliness, having never been without a dog before.I am now hopeful she may now change her mind, at least to* the extent of a Siamese cat, and that this may eventually permit corticosteroids to be tailed-off without relapse of her arteritis in one of its more unpleasant guises.This happened to a patient from the same practice only a few months back who stopped taking her prednisone, prescribed for her temporal arteritis, because the doctor emigrated.Her cardiac infarction, at first thought unremarkable, was followed by pericarditis and mental confusion, both of which, like her previous temporal arteritis, responded at once to prednisone.
Use of non-steroidal anti-inflammatory drugs (NSAIDs) as immunomodulatory agents
Authors: J. N. Fullerton
Journal: BMJ (2013)

I was delighted to see the BMJ Therapeutics series covering non-steroidal anti-inflammatory agents—a class of drugs that has perhaps been unfairly maligned and shunned recently.1 Although the article focused on the use of these drugs as analgesics, they can be used as immunomodulatory agents.

Clinicians commonly associate prostaglandins, the predominant downstream product of cyclo-oxygenase action on …
MCT-1 Protein Interacts with the Cap Complex and Modulates Messenger RNA Translational Profiles
Authors: Line S. Reinert, Bo Shi, Suvobroto Nandi, Krystyna Mazan-Mamczarz, Michele Vitolo, Kurtis E. Bachman, Huili He, Ronald B. Gartenhaus
Journal: Cancer Research (2006)

Abstract MCT-1 is an oncogene that was initially identified in a human T cell lymphoma and has been shown to induce cell proliferation as well as activate survival-related pathways. MCT-1 contains the PUA domain, a recently described RNA-binding domain that is found in several tRNA and rRNA modification enzymes. Here, we established that MCT-1 protein interacts with the cap complex through its PUA domain and recruits the density-regulated protein (DENR/DRP), containing the SUI1 translation initiation domain. Through the use of microarray analysis on polysome-associated mRNAs, we showed that up-regulation of MCT-1 was able to modulate the translation profiles of BCL2L2, TFDP1, MRE11A, cyclin D1, and E2F1 mRNAs, despite equivalent levels of mRNAs in the cytoplasm. Our data establish a role for MCT-1 in translational regulation, and support a linkage between translational control and oncogenesis. (Cancer Res 2006; 66(18): 8994-9001)
Care of the Aged: An English Lesson?
Authors: HELEN SMITS
Journal: Annals of Internal Medicine (1974)

A comparison of the services provided for the elderly in Great Britain and the United States shows the impact that organized medical care has on day-to-day clinical activities. The British have made many advances in geriatrics despite multiple problems that can often be traced to the three-part administrative structure of the National Health Service (NHS). The recent debate on the design of a new NHS administration raises questions that should concern Americans. Institutions designed to pay for and monitor health care need the flexibility and sensitivity to respond to innovations in the rapidly changing and very personal field of medical science. Issues such as the mechanisms for control both by consumers and providers should be considered when evaluating the many health care bills now before the United States Congress.
Data protection registrar calls for culture of privacy
Authors: D. Carnall
Journal: BMJ (1997)

The data protection registrar has called on the medical profession to adopt a culture of data privacy.

Speaking at a conference on healthcare computing in Harrogate last week, Ms Elizabeth France argued that the use of “pseudonymised data” could address some of the problems caused by the need for confidential medical data to be transferred within the NHS.



Can the Data Protection Act provide sufficient safeguards for medical privacy in the NHS-wide network?

N. PUNIN SIS PARIS



Many of the processes in the NHS internal market …
The Domain of General Internal Medicine: A Perspective from Trainees
Authors: Eric B. Larson
Journal: Annals of Internal Medicine (2004)

Letters5 October 2004The Domain of General Internal Medicine: A Perspective from TraineesEric B. Larson, MD, MPH, for the SGIM Task Force on the Domain of General Internal MedicineEric B. Larson, MD, MPHFrom Group Health Cooperative Center for Health Studies, Seattle, WA 98101-1448., for the SGIM Task Force on the Domain of General Internal MedicineAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-7-200410050-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree wholeheartedly that it is crucial that trainees be included in this conversation and are encouraged that ACP, SGIM, the American Board of Internal Medicine, and other organizations have included trainees in deliberations since the release of the SGIM Task Force report. We also agree that from a purely economic viewpoint there are downsides for both trainees and academic training programs in today's training configuration. However, the concept of the optional fourth year to train a master clinician transcends economics; it drives to the heart of what future internists need to optimally treat patients individually and to ...References1. Larson EB, Fihn SD, Kirk LM, Levinson W, Loge RV, Reynolds E, et al . The future of general internal medicine. Report and recommendations from the Society of General Internal Medicine (SGIM) Task Force on the Domain of General Internal Medicine. J Gen Intern Med. 2004;19:69-77. [PMID: 14748863] CrossrefMedlineGoogle Scholar2. Starting a conversation about the future of internal medicine [Editorial]. Ann Intern Med. 2004;140:659. LinkGoogle Scholar3. Committee on the Quality of Health Care in America, Institute of Medicine. Crossing the Quality Chasm: A New Health System for the 21st Century. Washington, DC: National Academy Pr; 2001. Accessed at www.iom.edu/report.asp?id=5432 on 17 February 2004. Google Scholar Author, Article, and Disclosure InformationAffiliations: From Group Health Cooperative Center for Health Studies, Seattle, WA 98101-1448. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHealth Care System Chaos Should Spur Innovation: Summary of a Report of the Society of General Internal Medicine Task Force on the Domain of General Internal Medicine Eric B. Larson and Starting a Conversation about the Future of Internal MedicineThe Domain of General Internal Medicine: A Perspective from Trainees Vineet Arora and Phil Hemstreet Metrics Cited ByThe Evolution of General Internal Medicine (GIM)in Canada: International Implications 5 October 2004Volume 141, Issue 7Page: 578KeywordsForecastingGraduate medical educationHeartPatient advocacy ePublished: 5 October 2004 Issue Published: 5 October 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Novel iontophoretic administration method for local therapy of breast cancer
Authors: Masahito Komuro, Kenichi Suzuki, Makoto Kanebako, Takashi Kawahara, Takeshige Otoi, Kenji Kitazato, Toshio Inagi, Kimiko Makino, Masakazu Toi, Hiroshi Terada
Journal: Journal of Controlled Release (2013)
Angiocardiographic Observations of Intracardiac Flow in the Normal and in Mitral Stenosis
Authors: LOUIS A. SOLOFF, JACOB ZATUCHNI, HERBERT M. STAUFFER, EUGENE W. KELLY
Journal: Circulation (1956)

Intracardiac flow of intravenously injected radiopaque material was studied by means of rapid simultaneous biplane stereoscopic angiocardiography. Intracardiac circulation times thus determined may be found useful in recognizing structural abnormality and in detecting changes in cardiac function. In mitral stenosis, a distinctive, but not specific, pattern was recognized whether or not mitral valvotomy had been performed. No relationship was found between left atrial size and left atrial circulation time or between the degree of opacification of the left atrium and that of the left ventricle to differentiate "pure" mitral stenosis from mitral stenosis with regurgitation as diagnosed at the time of surgery or to predict the degree of mitral stenosis reported by the surgeon.
90 HOXA13 AND HOTTIP EXPRESSION LEVELS PREDICT PATIENTS' SURVIVAL AND METASTASIS FORMATION IN HEPATOCELLULAR CARCINOMA
Authors: L. Quagliata, M. Matter, S. Piscuoglio, Z. Makowska, M. Heim, L. Tornillo, C. Cillo, L. Terracciano
Journal: Journal of Hepatology (2013)
On the Local Encouragement of Science by the State
Authors: H. W. Rumsey
Journal: BMJ (1857)

blood to pass from one auricle to the other.But a very different condition of things obtains during the diastole of the auricles; then, the blood, rushing from the vene cave and the pulmonary veins into the relaxed auricles, might readily find its way through an open foramen ovale, and, under certain conditions, conceivably produce such vibrations as would be re- presented by murmurs to the ear of the auscultator.How, in-
Severe metabolic acidosis early in paracetamol poisoning.
Authors: A Zezulka, N Wright
Journal: BMJ (1982)

Fasting venous blood was collected at 9 am into cooled heparinised tubes and centrifuged immediately, the plasma being stored at -20°C until assay.Calcitonin was measured in the plasma by direct immunoassay5 (five days of incubation) with a detection limit of 6-0 pg/tube and an intra-assay varia- tion of under 10%.All samples were assayed at the same time.Statistical evaluation was with the x2 test for variables with large numbers of undetectable values and the correlation calculated with Spearman's correlation coefficient.
Case management and community matrons for long term conditions
Authors: Elaine Murphy
Journal: BMJ (2004)

NHS." What is clear is that the standards were drafted by one agency (the Department of Health), the criteria and assessment process will be developed by another (the Healthcare Commission), and the products will be approved by a third (the Secretary of State).This does not bode well for coherent development or independent assessment.The standards include a catch all requirement that "healthcare organizations meet the existing performance requirements set out in the annex."These very specific targets pre-empt the development of criteria by the Healthcare Commission.Moreover, whether even these will be achieved is not clear.For example, the NHS Plan stated that by December 2004 people would have guaranteed access to a primary care doctor within 48 hours.Official figures show that performance had improved from 75% of cases in March 2002 to 97% in February 2004, 7 but independent surveys by the Picker Institute put the figure at 54% in 2004. 8o allowance is made for standards to be tested by providers and assessors to ensure they are understandable, relevant, and achievable.Nor is there provision for training of assessors or for preparatory selfevaluation by providers.The criteria and assessment process must be finalised by March 2005 and put into effect from April 2005.There is no process or timetable for evaluation and revision.The Healthcare Commission is faced with the impossible task of developing from these standards a robust and fair assessment process inside eight months.Experience in other countries suggests that the first cycle of a standards based assessment programme needs well defined procedures, simultaneous development of standards and criteria, and at least three years of preparation. 9he interests of all concerned, including the public, could be better served.For a start the Department of Health should publish where the standards came from and how they were selected.Reviews in the first year should be regarded primarily as tests of the system rather than true assessments of individual organisations.Radical redesign of the standards should begin after six months' use (in September 2005), rather than waiting for 2006-7.International guidance 10 should be followed in the design, development, and application of standards.The same guidance should be used by the Healthcare Commission to develop realistic, understandable, and measurable criteria for assessment and to adopt an assessment process that is proved to be reliable.The Department of Health has misjudged the research, technical expertise, and time needed to develop and test a fair and reliable process of external assessment.The burden will fall on the fledgling Healthcare Commission as assessor and on the early guinea pigs who are assessed.
The Clinical Spectrum of Papillary-Muscle Disease
Authors: Robert F. De Busk, Donald C. Harrison
Journal: New England Journal of Medicine (1969)

ALTHOUGH the role of the papillary muscles in mitral-valve closure has been appreciated for over a century1 , 2 the clinical importance of disease of these structures has emerged only within the past decade. It is now recognized that there is a broad clinical spectrum of papillary-muscle malfunction, ranging from a transient murmur in the asymptomatic patient with ischemic papillary-muscle dysfunction3 , 4 to florid mitral regurgitation and acute, fulminant pulmonary edema in the patient with papillary-muscle rupture.5 6 7 Ischemic malfunction of the papillary muscles was thought to cause mitral regurgitation as early as 1935,8 and this mechanism was further emphasized by Burch and Phillips . . .
NHS will be paperless by 2015, says commissioning board
Authors: M. Limb
Journal: BMJ (2012)

Paper records should be “eradicated” from the NHS as early as 2015, the NHS Commissioning Board’s national director for patients and information has said.

Tim Kelsey said he was “pushing” for a switchover to digital records by the end of 2015 and admitted it would be a “bold” move.

But a senior figure at the NHS Confederation said the deadline could prove “too ambitious” as some working practices could be hard to change.

Kelsey, a former Sunday Times journalist who co-founded the Dr Foster organisation that publishes consumer guides to UK health services …
Plight of Doctors in Central African Federation
Authors: D. E.C. Mekie
Journal: BMJ (1964)

slight chronic inflammatory reaction associated with a nematode worm, almost certainly Wuchereria bancrofti.A search for microfilariae, in blood films taken at night, was undertaken but none was found.The filarial complement fixation test was negative, and lymphangiograms did not demonstrate any lymphatic obstruction or other abnormality.However, in view of the histological findings he was given a course of Banocide, but unfortunately he has failed to attend the follow-up clinic.-I am, etc.
The Pediatric Patient, 1968
Authors: Marietta M. Henry
Journal: JAMA (1969)

Review books tend to be passive in nature, reciting the obvious and adding few new thoughts.<i>The Pediatric Patient, 1968</i>is no exception. In the pattern of earlier editions, it contains a general discussion rooted in the basic sciences, followed by selected, specialty-oriented topics. This year the text includes a technical presentation of enzymology, including the historical background of medical interest in enzymes. The section on orthopedic problems offers little but a review of physical diagnosis. The most interesting and useful chapter concerns neurology, with sections discussing the "at risk" infant, the minimal brain damage syndrome, intracranial tumors, and Wilson's disease. The last chapter in the book is a collection of short, wellreferenced statements of opinion on diverse subjects such as sports for children and the estimation of gestational age of an infant. The book suffers from the differing levels of quality of chapters and is not, in general, easily
Succinylcholine Effects in Anesthesia
Authors: John J. Savarese
Journal: JAMA (1973)

To the Editor.—  In reply to the suggestion of Drs. Kimbrough and Suggs (225:1532, 1973) that all patients who are to receive succinylcholine should be screened for atypical or low pseudocholinesterase, I offer the following comments:  First, the expense of performing several million dibucaine numbers per year would run into several millions of dollars, unnecessarily.  Second, a simple clinical test can be performed to evaluate the patient's ability to metabolize succinylcholine. One administers succinylcholine, 0.1 mg/kg of body weight, to the spontaneously breathing patient after anesthesia is induced. Clinically evident respiratory embarrassment occurs rarely after this dose in individuals able to metabolize succinylcholine normally. If respiratory depression does appear, it is transient and should clear spontaneously within less than five minutes. If, on the other hand, the patient isunableto metabolize the drug because he has an atypical enzyme or low enzyme activity, then he should develop severe paralysis,