Albuminuria and Mortality in Hypertension
Authors: Steven G. Coca, Gregory K. Buller
Journal: Annals of Internal Medicine (2004)

Letters3 August 2004Albuminuria and Mortality in HypertensionSteven G. Coca, DO and Gregory K. Buller, MDSteven G. Coca, DOFrom St. Mary's Hospital, Waterbury, CT 06706.Search for more papers by this author and Gregory K. Buller, MDFrom St. Mary's Hospital, Waterbury, CT 06706.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-3-200408030-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In the substudy of the Losartan Intervention For Endpoint reduction (LIFE) trial by Wachtell and colleagues (1), increasing baseline urinary albumin–creatinine ratio (UACR) in patients with hypertension and left ventricular hypertrophy was associated with increased risk for cardiovascular morbidity and mortality. In a previous report by the same authors (2), log UACRs were significantly correlated with systolic and diastolic blood pressure, and patients with microalbuminuria and macroalbuminuria had significantly higher systolic and diastolic blood pressure (P < 0.001) than patients with normal UACRs. Other studies have confirmed the tight relationship between hypertension and microalbuminuria, using 24-hour ambulatory blood ...References1. Wachtell K, Ibsen H, Olsen MH, Borch-Johnsen K, Lindholm LH, Mogensen CE, et al . Albuminuria and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE study. Ann Intern Med. 2003;139:901-6. [PMID: 14644892] LinkGoogle Scholar2. Wachtell K, Olsen MH, Dahlöf B, Devereux RB, Kjeldsen SE, Nieminen MS, et al . Microalbuminuria in hypertensive patients with electrocardiographic left ventricular hypertrophy: the LIFE study. J Hypertens. 2002;20:405-12. [PMID: 11875307] CrossrefMedlineGoogle Scholar3. Bianchi S, Bigazzi R, Baldari G, Sgherri G, Campese VM. Diurnal variations of blood pressure and microalbuminuria in essential hypertension. Am J Hypertens. 1994;7:23-9. [PMID: 8136107] CrossrefMedlineGoogle Scholar4. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360:1903-13. [PMID: 12493255] CrossrefMedlineGoogle Scholar5. Olsen MH, Wachtell K, Borch-Johnsen K, Okin PM, Kjeldsen SE, Dahlöf B, et al . A blood pressure independent association between glomerular albumin leakage and electrocardiographic left ventricular hypertrophy. The LIFE Study. Losartan Intervention For Endpoint reduction. J Hum Hypertens. 2002;16:591-5. [PMID: 12149666] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From St. Mary's Hospital, Waterbury, CT 06706. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAlbuminuria and Cardiovascular Risk in Hypertensive Patients with Left Ventricular Hypertrophy: The LIFE Study Kristian Wachtell , Hans Ibsen , Michael H. Olsen , Knut Borch-Johnsen , Lars H. Lindholm , Carl Erik Mogensen , Bjrn Dahlf , Richard B. Devereux , Gareth Beevers , Ulf de Faire , Frej Fyhrquist , Stevo Julius , Sverre E. Kjeldsen , Krister Kristianson , Ole Lederballe-Pedersen , Markku S. Nieminen , Peter M. Okin , Per Omvik , Suzanne Oparil , Hans Wedel , Steven M. Snapinn , and Peter Aurup Albuminuria and Mortality in Hypertension Kristian Wachtell , Michael Hecht Olsen , and Hans Ibsen Metrics Cited ByReactive Oxygen Species in the Pathogenesis of Chronic Kidney Disease: Lessons Derived from Diabetic Nephropathy 3 August 2004Volume 141, Issue 3Page: 244-245KeywordsBlood pressureCardiovascular diseasesDeath ratesHypertensionLeft ventricular hypertrophyMicroalbuminuriaMortalityProspective studiesStrokeSystolic pressure ePublished: 3 August 2004 Issue Published: 3 August 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...