Erythropoiesis and Ferrokinetics in Chronic Respiratory Disease
Authors: M. LERTZMAN
Journal: Annals of Internal Medicine (1962)

Article1 June 1962Erythropoiesis and Ferrokinetics in Chronic Respiratory DiseaseM. LERTZMAN, M.D., L. G. ISRAELS, M.D., F.R.C.P. (C), R. M. CHERNIACK, M.D., F.R.C.P. (C), F.A.C.P.M. LERTZMAN, M.D.Search for more papers by this author, L. G. ISRAELS, M.D., F.R.C.P. (C)Search for more papers by this author, R. M. CHERNIACK, M.D., F.R.C.P. (C), F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-6-821 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChronic exposure to high altitude leads to the development of secondary polycythemia which is roughly proportional to the degree of hypoxia (1, 2). The hematopoietic response to altitude hypoxia has been further delineated by measurement of the rate of movement of radioactive iron out of the plasma and its subsequent incorporation in the red blood cells (3).Although patients who are hypoxic because of cardiorespiratory disease also develop secondary polycythemia, it has been suggested that many patients with pulmonary emphysema do not respond normally to the hypoxic stimulus (4, 5). It was of interest, therefore, to study the ferrokinetic and...References1. VIAULT E: Sur la quantite d'oxygene contenue dans le sang des animaux des hauts plateaux de l'Amerique du Sud. Acad. Sci. Paris 112: 295, 1891. Google Scholar2. HURTADOMERINODELGADO ACE: Influence of anoxemia on hemopoietic activity. Arch. Intern. Med. 75: 284, 1954. CrossrefGoogle Scholar3. HUFFLAWRENCESERIWASSERMANHENNESSY RLJHWELRFG: Effects of changes in altitude on hematopoietic activity. Medicine (Balt.) 30: 197, 1951. CrossrefMedlineGoogle Scholar4. 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BUSHASHENBRUCKERCARTWRIGHTWINTROBE JAHGEMM: The anemia of infection. 10. The kinetics of iron metabolism in the anemia associated with chronic infection. J. Clin. Invest. 35: 89, 1956. CrossrefMedlineGoogle Scholar33. LERTZMANISRAELSCHERNIACK MLGRM: Unpublished data. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Winnipeg,From the Departments of Medicine and Pediatrics, The University of Manitoba, and the Clinical Investigation Units of the General and Children's Hospitals, Winnipeg, Manitoba, Canada.Supported by grants from the Manitoba Heart Association, the National Cancer Institute of Canada, and the Medical Research Council of Canada.Requests for reprints should be addressed to R. M. Cherniack, M.D., The University of Manitoba, Faculty of Medicine, Medical Buildings, Bannatyne and Emily, Winnipeg 3, Canada. 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