tbuckley/cabot-search huggingface dataset:
Gemtuzumab Ozogamicin as Part of Reduced-Intensity Conditioning for Allogeneic Hematopoietic Cell Transplantation in Patients with Relapsed Acute Myeloid Leukemia
Authors: Martin Bornhäuser, Thomas Illmer, Uta Oelschlaegel, Johannes Schetelig, Rainer Ordemann, Markus Schaich, Mathias Hänel, Ulrich Schuler, Christian Thiede, Alexander Kiani, Uwe Platzbecker, Gerhard Ehninger
Journal: Clinical Cancer Research (2008)

Abstract Purpose: Gemtuzumab ozogamicin (GO) has been associated with an increased risk of liver sinusoidal obstruction syndrome (SOS) when applied within 3 months of allogeneic hematopoietic cell transplantation (HCT). We hypothesized that GO might be safe and effective as part of a reduced-intensity conditioning regimen as salvage therapy of CD33+ acute myeloid leukemia. Experimental Design: Thirty-one patients with acute myeloid leukemia which relapsed following conventional therapy (n = 15), autologous (n = 3), or allogeneic (n = 13) HCT were included in a prospective phase I/II trial. The preparative regimen contained 6 and 3 mg/m2 of GO on days −21 and −14 before transplantation, leading to a reduction of marrow blasts in 18 patients (58%). Eight patients received further cytoreductive chemotherapy before conditioning therapy was initiated. Fludarabine-based reduced-intensity (n = 11) or nonmyelablative (n = 16) conditioning and peripheral blood stem cell infusion from related (n = 6) or unrelated (n = 21) donors could be done in 27 patients during cytopenia. Results: Primary engraftment occurred in all evaluable patients. Only one case of reversible hepatic sinusoidal obstruction syndrome was documented. Non–relapse mortality until day 100 was 22% (n = 6). The probabilities of overall and disease-free survival at 24 months were 39% and 35%, respectively. Relapse of leukemia occurring between 2 and 24 months after transplantation (median, 8 months) was the major reason for treatment failure and death. Conclusion: These data suggest that GO can be combined with reduced-intensity conditioning even after previous autologous or allogeneic HCT.
Causes of Acute Hospitalization in Adolescence: Burden and Spectrum of HIV-Related Morbidity in a Country with an Early-Onset and Severe HIV Epidemic: A Prospective Survey
Authors: Rashida A. Ferrand, Tsitsi Bandason, Praise Musvaire, Natasha Larke, Kusum Nathoo, Hilda Mujuru, Chiratidzo E. Ndhlovu, Shungu Munyati, Frances M. Cowan, Diana M. Gibb, Elizabeth L. Corbett
Journal: PLoS Medicine (2010)

Survival to older childhood with untreated, vertically acquired HIV infection, which was previously considered extremely unusual, is increasingly well described. However, the overall impact on adolescent health in settings with high HIV seroprevalence has not previously been investigated.Adolescents (aged 10-18 y) systematically recruited from acute admissions to the two public hospitals in Harare, Zimbabwe, answered a questionnaire and underwent standard investigations including HIV testing, with consent. Pre-set case-definitions defined cause of admission and underlying chronic conditions. Participation was 94%. 139 (46%) of 301 participants were HIV-positive (median age of diagnosis 12 y: interquartile range [IQR] 11-14 y), median CD4 count = 151; IQR 57-328 cells/microl), but only four (1.3%) were herpes simplex virus-2 (HSV-2) positive. Age (median 13 y: IQR 11-16 y) and sex (57% male) did not differ by HIV status, but HIV-infected participants were significantly more likely to be stunted (z-score<-2: 52% versus 23%, p<0.001), have pubertal delay (15% versus 2%, p<0.001), and be maternal orphans or have an HIV-infected mother (73% versus 17%, p<0.001). 69% of HIV-positive and 19% of HIV-negative admissions were for infections, most commonly tuberculosis and pneumonia. 84 (28%) participants had underlying heart, lung, or other chronic diseases. Case fatality rates were significantly higher for HIV-related admissions (22% versus 7%, p<0.001), and significantly associated with advanced HIV, pubertal immaturity, and chronic conditions.HIV is the commonest cause of adolescent hospitalisation in Harare, mainly due to adult-spectrum opportunistic infections plus a high burden of chronic complications of paediatric HIV/AIDS. Low HSV-2 prevalence and high maternal orphanhood rates provide further evidence of long-term survival following mother-to-child transmission. Better recognition of this growing phenomenon is needed to promote earlier HIV diagnosis and care.
Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages
Authors: Masato Murakami, Shinobu Iwai, Sachie Hiratsuka, Mai Yamauchi, Kazuhide Nakamura, Yoichiro Iwakura, Masabumi Shibuya
Journal: Blood (2006)
Hemangioma of the Spleen Confirmed by Blood Pool Scintigraphy
Authors: Vera Artiko, Vladimir Obradović, Milorad Petrović, Mirjana Perišić-Savić, Nadežda Suvajdzic
Journal: Clinical Nuclear Medicine (2004)

A patient with suspected splenic hemangioma showed an area of absent radioactivity at the lower pole of the spleen on Tc-99m stannous colloid imaging. Increased activity was seen in the same area on Tc-99m RBC blood pool imaging. These findings were consistent with a splenic hemangioma.
Feasibility of identifying amyloid and hypertrophic cardiomyopathy with the use of computerized quantitative texture analysis of clinical echocardiographic data
Authors: Krishnaswamy Chandrasekaran, Philip E. Aylward, Steven R. Fleagle, Trudy L. Burns, James B. Seward, A.Jamil Tajik, Steve M. Collins, David J. Skorton
Journal: Journal of the American College of Cardiology (1989)
Secondary prevention clinics for coronary heart disease: randomised trial of effect on health
Authors: N. C Campbell, J. Thain, H G. Deans, L. D Ritchie, J. M Rawles, J. L Squair
Journal: BMJ (1998)

<h3>Abstract</h3> <b>Objective</b>: To evaluate the effects of secondary prevention clinics run by nurses in general practice on the health of patients with coronary heart disease. <b>Design</b>: Randomised controlled trial of clinics over one year with assessment by self completed postal questionnaires and audit of medical records at the start and end of the trial. <b>Setting</b>: Random sample of 19 general practices in northeast Scotland. <b>Subjects</b>: 1173 patients (685 men and 488 women) under 80 years with working diagnoses of coronary heart disease who did not have terminal illness or dementia and were not housebound. <b>Intervention</b>: Clinic staff promoted medical and lifestyle aspects of secondary prevention and offered regular follow up. <b>Main outcome measures</b>: Health status measured by the SF-36 questionnaire, chest pain by the angina type specification, and anxiety and depression by the hospital anxiety and depression scale. Use of health services before and during the study. <b>Results</b>: There were significant improvements in six of eight health status domains (all functioning scales, pain, and general health) among patients attending the clinic. Role limitations attributed to physical problems improved most (adjusted difference 8.52, 95% confidence interval 4.16 to 12.9). Fewer patients reported worsening chest pain (odds ratio 0.59, 95% confidence interval 0.37 to 0.94). There were no significant effects on anxiety or depression. Fewer intervention group patients required hospital admissions (0.64, 0.48 to 0.86), but general practitioner consultation rates did not alter. <b>Conclusions</b>: Within their first year secondary prevention clinics improved patients9 health and reduced hospital admissions. <h3>Key messages</h3> Nurse led clinics in general practice were used to promote secondary prevention to patients with coronary heart disease Within the first year the health of patients invited to the clinics improved Most benefit was in functional status, but chest pain improved too There was no effects on anxiety or depression There were significant reductions in hospital admissions in the first year
Cutaneous lobular neuromyxoma
Authors: C.A. HOLDEN, E. WILSON-JONES, D.M. MAcDONALD
Journal: British Journal of Dermatology (1982)

Six cutaneous tumours of distinctive clinical and histological pattern are described. These lesions have infrequently been previously reported under a variety of names but may be more easily recognized by the descriptive title cutaneous lobular neuromyxoma.
CLINICAL AND ECHOCARDIOGRAPHIC CHARACTERISTICS OF HEART FAILURE PATIENTS WITH WIDE QRS BUT WITHOUT MECHANICAL DYSSYNCHRONY AND THEIR RESPONSE TO RESYNCHRONIZATION THERAPY
Authors: Hidekazu Tanaka, Olusegun Oyenuga, Phillip Habib, Stephanie Haberman, Samir Saba, John Gorcsan
Journal: Journal of the American College of Cardiology (2010)
Community hospital administration of intravenous tissue plasminogen activator in acute myocardial infarction: Improved timing, thrombolytic efficacy and ventricular function
Authors: Eric J. Topol, Eric R. Bates, Joseph A. Walton, Gregory Baumann, Stanley Wolfe, John Maino, Leonard Bayer, Laura Gorman, Eva M. Kline, William W. O’Neill, Bertram Pitt
Journal: Journal of the American College of Cardiology (1987)
Sequential analysis of kidney stone formation in the Aprt knockout mouse
Authors: Andrew P. Evan, Sharon B. Bledsoe, Bret A. Connors, Li Deng, Li Liang, Changshun Shao, Naomi S. Fineberg, Marc D. Grynpas, Peter J. Stambrook, Shao Youzhi, Amrik Sahota, Jay A. Tischfield
Journal: Kidney International (2001)
The Physician and the Pharmacopeia.
Authors: William J. Robinson
Journal: JAMA (1906)

New York, Feb. 18, 1906. <h3>To the Editor:</h3> —I thank you for your courtesy in printing my letter with the above title in your pages (February 17, p. 526). Your answer, however, requires a reply on my part. You say: "We do not believe anyone suggests that we should be limited to Pharmacopeial preparations." And further you make the statement: "Our correspondent, like too many others, has set up a straw man to knock down." Now, I am not given to setting up straw men, and I am not very likely to make absurd statements, when the subject of proprietary remedies is under discussion, as I have studied the question from all sides, in all its phases, and at a time when too many who show now such commendable zeal on the subject were an absolute<i>terra incognita</i>. I could name you a dozen good, but ignorant men, who just
THE INFLUENCE OF DIET UPON THE REGENERATION OF SERUM PROTEIN
Authors: Daniel Melnick, George R. Cowgill, Ethel Burack
Journal: The Journal of Experimental Medicine (1936)

1. From a consideration of previous work related to the problem of the influence of diet upon the regeneration of serum protein, a plan of study is described which eliminates the many variables shown to be operating in the studies conducted by these pioneer workers. 2. By the administration of a protein-free diet at a high level of caloric intake to the dog subjected to plasmapheresis during which one-fourth of the blood volume of the animal is withdrawn daily, it is possible to reduce the serum protein concentration to the basal level (3.5 to 4.2 per cent) and to deplete the organism of its reserve stores of this protein within 1 week. The subsequent week has been demonstrated to be an equilibrium period. 3. The dog contains a reserve store of serum protein building material equivalent to about 30 to 40 per cent of the total amount normally present in the circulation. 4. When fed the protein-free diet and when subjected to quantitative plasmapheresis, whereby the basal level of the serum protein concentration is maintained constant, the dog is able in 1 week to regenerate approximately 20 to 30 per cent of the total amount of this blood protein normally present in the plasma. 5. The administration of a diet favorable for promoting the regeneration of serum protein requires approximately 4 to 5 days before a constant and maximal response to the dietary stimulus is obtained. Equilibrium data are yielded during the 2nd week, and these are employed in calculating the potency ratio of the dietary protein.
New health minister outlines future for South Africa
Authors: P Sidley
Journal: BMJ (1994)

South Africa's new health minister, Nkosezana Zuma, has announced that there will be swift improvements to the nation's health care under the new government. Some of the first changes will include nutritional feeding schemes in schools, free health care for children under 6, and toughened health warnings on cigarette packets.

Dr Zuma will have the backing of two major policy documents: the final plan of the African National Congress (ANC) for a national health system and the reconstruction and development plan of the government and the ANC for housing, health, …
Abstract 5333: Novel Ab treatment tool for CRC
Authors: Shiran Shapira, Sarah Kraus, Dina Kazanov, Rolf Stahel, Irai Benhar, Nadir Arber
Journal: Cancer Research (2010)

Abstract Background: We have shown that CD24, a cell surface molecule, is overexpressed early in the multistep process of colorectal neoplasia (Gastroenterology, 2006) hence, it can serve as a target for early detection and immunotherapy. The anti-CD24 murine SWA11 Mab (generous gift from Prof. Sthal, Zurich University) binds to CD24 and inhibits tumor cell growth, in vitro and in vivo, in a time- and dose-dependent manner (Cancer Research, 2008). However, murine Mabs have limitations because of their xenogeneic nature and due to the human anti-mouse antibody (HAMA) response. Aim: To produce an improved, chimeric form of the SWA11 Mab. Methods: Mammalian vector pMAZ-IgH for human γ1 heavy-chain and pMAZ-IgL for human κ light chain expression were designed. The variable region genes encoding the murine anti-CD24 SWA11 MAb were cloned for expression as chimeric γ1/kappa antibody into the mammalian pMAZ-IgH and pMAZ-IgL expression vectors and co-transfected into HEK293 cells. Stable clones were screened and selected for IgG production, analyzed by whole-cell and antigen-based ELISA, and Western blotting. Results: The new chimeric IgG derivative of the anti-CD24 SWA11 Mab possesses similar affinity and specificity (ELISA and Western blot), but has improved activity in inhibiting cell growth. The chimeric Mabs also have the ability to induce complement-dependent cytotoxicity, causing up to 60% cell lysis in the presence of complement. Conclusions: We had successfully generated a chimeric IgG derivative of the anti-CD24 SWA11 Mab that can serve as a novel therapeutic tool for cancer cells harboring CD24. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5333.
Permanent Cardiac Pacemakers in Alaska Natives With Complete Heart Block
Authors: Gary A. Katz
Journal: JAMA (1970)

Sixteen Alaska natives have been followed up after permanent cardiac pacemaker implantation, from July 1965 to May 1970. The indication for pacemaker implantation was persistent symptomatic complete heart block. The longest follow-up period was 57 months. The average follow-up period per patient was 17 months. There was no mortality during this time with a small number of pacemaker failures or complications. Many of the patients returned to live in remote villages. The success of this program indicates that permanent pacemakers can be used in patients who live in rural settings, far from hospital centers, as long as appropriate follow-up methods are employed.
Kokopelli of Indian paleology. Hunchbacked rain priest, hunting magician, and Don Juan of the old Southwest
Authors: K. F. Wellmann
Journal: JAMA (1970)

The hot and arid southwestern portion of the United States harbors an imposing array of prehistoric Indian rock paintings and carvings some of which date back thousands of years.<sup>2</sup>The intentional or incidental confrontation with these charming witnesses of bygone cultures evokes one of the most delightful experiences for anyone who travels through this region with a receptive mind. Perhaps the most intriguing of all the petroglyphs and pictographs of the Southwest is a distinguished little anthropomorphic figure known among a small circle of cognoscenti under the euphonious name of "Kokopelli" (a word said to stem from the Zuñi and Hopi dialects<sup>3</sup>; other spellings include Kokopeli, Kokopele, Kokopölö and Kokopeltiyo). Kokopelli (Fig 1 through 5) appears on countless rocks<sup>4-7</sup>(Fig 1 and 3), in rock shelters,<sup>8</sup>ceremonial caves<sup>3</sup>(Fig 4) and kivas, and on the walls of some Pueblo ruins and can be found in
Influenza vaccination in adults with cystic fibrosis.
Authors: E L Ong, D Bilton, J Abbott, A K Webb, R A McCartney, E O Caul
Journal: BMJ (1991)

/?iW71991;303:557 Respiratory viruses, particularly influenza viruses, cause infective respiratory exacerbations and dete? rioration of pulmonary function in patients with cystic fibrosis.12 Moreover, these patients have an increased risk of dying from influenza or its complications.3 Patients may, however, fear vaccination because of the flu-like side effects. We report a two year study of the clinical effect and antibody response after influenza vaccination in adults with cystic fibrosis and healthy volunteers.
Constitutively Active Stat3 Enhances Neu-Mediated Migration and Metastasis in Mammary Tumors via Upregulation of Cten
Authors: Isaia Barbieri, Sara Pensa, Tania Pannellini, Elena Quaglino, Diego Maritano, Marco Demaria, Alessandra Voster, James Turkson, Federica Cavallo, Christine J. Watson, Paolo Provero, Piero Musiani, Valeria Poli
Journal: Cancer Research (2010)

Abstract The transcription factor signal transducer and activator of transcription 3 (STAT3) is constitutively activated in tumors of different origin, but the molecular bases for STAT3 requirement are only partly understood. To evaluate the contribution of enhanced Stat3 activation in a controlled model system, we generated knock-in mice wherein a mutant constitutively active Stat3C allele replaces the endogenous wild-type allele. Stat3C could enhance the tumorigenic power of the rat Neu oncogene in mouse mammary tumor virus (MMTV)–Neu transgenic mice, triggering the production of earlier onset, more invasive mammary tumors. Tumor-derived cell lines displayed higher migration, invasion, and metastatic ability and showed disrupted distribution of cell-cell junction markers mediated by Stat3-dependent overexpression of the COOH terminal tensin-like (Cten) focal adhesion protein, which was also significantly upregulated in Stat3C mammary tumors. Importantly, the proinflammatory cytokine interleukin-6 could mediate Cten induction in MCF10 cells in an exquisitely Stat3-dependent way, showing that Cten upregulation is a feature of inflammation-activated Stat3. In light of the emerging pivotal role of Stat3 in connecting inflammation and cancer, our identification of Cten as a Stat3-dependent mediator of migration provides important new insights into the oncogenic role of Stat3, particularly in the breast. Cancer Res; 70(6); 2558–67
Identification of a Potential Role for the Adventitia in Vascular Lesion Formation After Balloon Overstretch Injury of Porcine Coronary Arteries
Authors: Neal A. Scott, Gustavo D. Cipolla, Cheryl E. Ross, Bradley Dunn, Francis H. Martin, Lizette Simonet, Josiah N. Wilcox
Journal: Circulation (1996)

Background In the present series of experiments, we examined the onset of cell proliferation and growth factor expression after balloon overstretch injury to porcine coronary arteries. Methods and Results Domestic juvenile swine underwent balloon overstretch injury to the left anterior descending and circumflex coronary arteries with standard percutaneous transluminal coronary angioplasty balloon catheters. To identify proliferating cells, 5-bromo-2-deoxyuridine (BrDU) was administered over a period of 24 hours before the animals were killed at either 1, 3, 7, or 14 days after injury. Immunohistochemistry was performed with monoclonal antibodies to BrDU and smooth muscle cell markers. Three days after injury, a large number of proliferating cells were located in the adventitia, with significantly fewer positive cells found in the media and lumen. Seven days after injury, proliferating cells were found primarily in the neointima, extending along the luminal surface. In situ hybridization for PDGF A-chain and β-receptor mRNAs revealed that the expression of these two genes was closely correlated with the sites of proliferation at each time point. Studies in which BrDU was injected between days 2 and 3 and the animals were killed on day 14 suggested that the proliferating adventitial cells may migrate into the neointima. Conclusions These data suggest that adventitial myofibroblasts contribute to the process of vascular lesion formation by proliferating, synthesizing growth factors, and possibly migrating into the neointima. Increased synthesis of α-smooth muscle actin observed in the adventitial cells after arterial injury may constrict the injured vessel and contribute to the process of arterial remodeling and late lumen loss after angioplasty.
The Proposed National Bureau of Medicines and Foods.
Authors: Philip Mills Jones
Journal: JAMA (1904)

San Francisco, Jan. 7, 1904. <h3>To the Editor:</h3> —Correspondence with the Joint Committee on a National Bureau of Medicines and Foods has developed several questions, one of which I should like to present through your columns for the purpose of eliciting suggestions. The question raised is as to the need for any such organization. There seems to be no dispute as to the truth of the fact that medicines and foods do not come up to fair standards of purity and identity. It is also agreed by all that many poor or worthless preparations of both pharmacopeial and extrapharmacopeial preparations are on the market and are largely used. No one—especially no one in any way connected with medical journalism—has questioned the desirability of securing some means of determining the status of the host of mixtures, some ethical, some "proprietary," and some out-and-out nostrums, which now exist. The question at issue
Benign Jaundice of Pregnancy
Authors: Parakrama de Silva
Journal: JAMA (1965)

BENIGN JAUNDICE of pregnancy has been described in Europe, but reports from North America are rare. It is believed that the few reports from North America are due to a lack of general awareness of this entity. The purpose of this article is to present a typical case of the disease.  Report of a Case  The patient, a 19-year-old white primigravida, was admitted to the Ottawa General Hospital because of jaundice. This was recognized during a routine visit to the Pre-Natal Clinic two days previously. She was 30 weeks pregnant.  On admission, she gave a history of colds for about two weeks characterized by a stuffy nose, cough, fever, and chills. There was no history of a sore throat. One week prior to admission she noticed that her stools were lighter than normal in color and about four days later, her urine became dark-colored. She complained of generalized pruritus for
Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation
Authors: L Reiniger, C Bödör, Á Bognár, Z Balogh, J Csomor, Á Szepesi, L Kopper, A Matolcsy
Journal: Leukemia (2006)