Carotid Atherosclerosis and Rheumatoid Arthritis
Authors: Jane E. Salmon, Stephen A. Paget, Mary J. Roman
Journal: Annals of Internal Medicine (2006)

Letters1 August 2006Carotid Atherosclerosis and Rheumatoid ArthritisJane E. Salmon, MD, Stephen A. Paget, MD, and Mary J. Roman, MDJane E. Salmon, MDFrom Hospital for Special Surgery, and Weill Medical College of Cornell University, New York, NY 10021.Search for more papers by this author, Stephen A. Paget, MDFrom Hospital for Special Surgery, and Weill Medical College of Cornell University, New York, NY 10021.Search for more papers by this author, and Mary J. Roman, MDFrom Hospital for Special Surgery, and Weill Medical College of Cornell University, New York, NY 10021.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-3-200608010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE: We, too, expected to find a relationship between markers of systemic inflammation and evidence of carotid atherosclerosis in patients with rheumatoid arthritis. Although our study did not define the mediators of accelerated atherosclerosis or the markers that predict it, we believe our findings support an important role for chronic inflammation. The analyses suggested by Dr. Targher showed no association between autoantibodies (rheumatoid factor or anti-CCP antibodies) and the presence of carotid atherosclerosis in our patients. Carotid plaque was detected in 49% of patients with positive results for rheumatoid factor and in 46% of patients with negative results for ...References1. Berglin E, Johansson T, Sundin U, Jidell E, Wadell G, Hallmans G, et al. Radiological outcome in rheumatoid arthritis is predicted by presence of antibodies against cyclic citrullinated peptide before and at disease onset, and by IgA-RF at disease onset. Ann Rheum Dis. 2006;65:453-8. [PMID: 16176994] CrossrefMedlineGoogle Scholar2. Roman MJ, Shanker BA, Davis A, Lockshin MD, Sammaritano L, Simantov R, et al. Prevalence and correlates of accelerated atherosclerosis in systemic lupus erythematosus. N Engl J Med. 2003;349:2399-406. [PMID: 14681505] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Hospital for Special Surgery, and Weill Medical College of Cornell University, New York, NY 10021.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoPreclinical Carotid Atherosclerosis in Patients with Rheumatoid Arthritis Mary J. Roman , Elfi Moeller , Adrienne Davis , Stephen A. Paget , Mary K. Crow , Michael D. Lockshin , Lisa Sammaritano , Richard B. Devereux , Joseph E. Schwartz , Daniel M. Levine , and Jane E. Salmon Carotid Atherosclerosis and Rheumatoid Arthritis Giovanni Targher Metrics 1 August 2006Volume 145, Issue 3Page: 231KeywordsAntibodiesAtherosclerosisAutoantibodiesConflicts of interestFactor analysisImmunomodulationInflammationMorbidityRheumatoid arthritis ePublished: 1 August 2006 Issue Published: 1 August 2006 CopyrightCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...