tbuckley/cabot-search huggingface dataset:
Assessment of Glycosylated Hemoglobin Measurement With Sample Collection Papers
Authors: Christiane Broussolle, Christopher D Saudek
Journal: Diabetes Care (1987)

It would be advantageous to be able to measure glycosylated hemoglobin (GHb) from a sample of blood dried on paper and sent to the physician by the patient. Indeed, such a technique has been introduced by Isolab (Akron, OH). We tested the validity of the method to determine whether 1) applying the blood to paper and immediately assaying it correlates with the same sample assayed by the usual wholeblood technique, 2) the size of sample applied to paper affects apparent GHb results, 3) time and temperature of storage of the sample paper affect apparent GHb resu ts, and 4) plasma glucose concentration of the sample affects GHb results. The GHb of samples assayed immediately after application to sample paper versus those assayed as whole blood showed very good correlation (r = .93, P &amp;lt; .001). Volume of the drop of blood applied to paper (25–100 μl) did not affect results. However, there was a dramatic, temperature-dependent increase in apparent GHb when samples were stored on sample paper, averaging 12.5, 16.3, and 19.5% when stored at room temperature for 3, 6, and 9 days, respectively. Overall, apparent GHb rose from 1.3-fold in 3 days at 4°C to 3.8-fold in 9 days at 37°C. The rate of GHb formation was proportional to plasma glucose concentration, but removal of free glucose by ethanol or glucose oxidase did not yield consistent results for this method. We conclude that these sample papers are not useful as an approach to collecting blood samples for GHb measurement.
Use of community genetic screening to prevent HFE-associated hereditary haemochromatosis
Authors: MB Delatycki, KJ Allen, AE Nisselle, V Collins, S Metcalfe, D du Sart, J Halliday, MA Aitken, I Macciocca, V Hill, A Wakefield, A Ritchie, AA Gason, AJ Nicoll, LW Powell, R Williamson
Journal: The Lancet (2005)
Is the Teaching Hospital an Endangered Species?
Authors: William B. Schwartz, Joseph P. Newhouse, Albert P. Williams
Journal: New England Journal of Medicine (1985)

The nonmunicipal teaching hospital faces some special challenges in adapting to the increasingly austere fiscal environment in which all hospitals must operate. However, except in a few instances, such developments as constraints on Medicaid expenditures do not appear to be notably more serious for teaching hospitals than for their community counterparts. The teaching hospitals most closely connected with medical schools provide more charity care and carry more bad debt than community hospitals. But other teaching hospitals have about the same burden as their community counterparts. The most serious problem facing teaching hospitals results from new bases of prospective reimbursement, some of which do not adequately compensate hospitals that treat more "difficult" cases--that is, more expensive cases. Competitive providers of health care such as health maintenance organizations promise to reduce admissions at all types of hospitals; whether this reduction will selectively affect teaching hospitals is not yet clear. By contrast, the fiscal state of municipal teaching hospitals is far more precarious than that of their nonmunicipal counterparts. The ability of these institutions to maintain high-quality patient care and teaching programs is in considerable jeopardy.
Severe Vomiting in Pregnancy, Due to Alcoholism: With Remarks
Authors: A. W. Edis
Journal: BMJ (1885)

THis is an epidemic of bee-hives affecting.especially 'the larvae, and resulting in the death of the larvae, which degenerate and form a yellowish and black stringy material at the bottom of the cell-the "foulbroody matter."Mr. Cheshire, who has chiefly investigated the matter, finds that the disease is not confined to the'larvae, but affects the adult bees, more 'especially the workers, which die' off in large numbers.He also,found it as a local disease affecting one of the ovaries of a queen-bee, and leading to infection of the ova'of that bee.'If the foulbroodv material is examined, it is found to contain numbers of oval bodies, which have been described by some as micrococci, by others as one of the Saccharomyces (cryptococcus alvearius).Mr. Cheshire, however, found that these bodies were not present in the juices of the larvae-that there one only saw moving bacilli-and he has made out the same fact with regard to the adult bees affected with the disease.He therefore regards it as a bacillar disease.In August last he brought me some foulbroody material to see if the organism could be cultivated, and it is the result of this research which forms the subject of' the present communication.And I may say shortly that from this material I got a growth of bacilli exactly re- semblling in size and appearance those seen in the juices of the larvas and adult bees, and that these bacilli produced large spores, which were evidently the bodies seen in the foulbroody material.
Cognitive impairment in heart failure: results from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME‐CHF) randomized trial
Authors: Marjolein Huijts, Robert J. van Oostenbrugge, Annelien Duits, Thilo Burkard, Stefano Muzzarelli, Micha T. Maeder, Ruth Schindler, Matthias E. Pfisterer, Hans‐Peter Brunner‐La Rocca
Journal: European Journal of Heart Failure (2013)
Cardiac Patients’ Herbal Supplement Use Deserves More Careful Investigation
Authors: Rebecca Voelker
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence and Risk Factors for Diabetes and Diabetes-Related Amputations in American Indians In Southern Arizona
Authors: Robert B Wirth, Anthony A Marfin, David W Grau, Steven D Helgerson
Journal: Diabetes Care (1993)

OBJECTIVE— To describe the prevalence of NIDDM and LEA using data from a computer-based patient data base. RESEARCH DESIGN AND METHODS— Diabetic patients with and without LEA, and nondiabetic patients were identified by computer search. Charts of diabetic patients were reviewed for confirmation of diagnosis of diabetes and diabetes-related amputation. The diabetic and nondiabetic populations were described, and certain risk factors were identified. RESULTS— The overall prevalence of NIDDM in this tribe in 1985–1986 was 18.3/100 adults (≥ 18 yr of age), whereas the prevalence of LEA/100 adults with NIDDM was 10.3%. Females were 1.3 times as likely to have diagnosed diabetes as males (95% CI 1.2–1.4), and males with diabetes were 1.4 times more likely to have had LEA than females with diabetes (95% CI 1.1–1.9). CONCLUSIONS— Automated health-care delivery data base used for this tribe can be used to maintain surveillance for diabetes and amputations in diabetic patients. Effective programs to prevent complications of diabetes, such as LEA, in this tribe are urgently needed.
Dangerousness as the Criterion for Involuntary Hospitalization: A Time to Reassess
Authors: Pauline Rabin
Journal: JAMA (1981)

The law in the state of Tennessee setting emergency involuntary commitment standards permits immediate detention of a patient for the purposes of diagnosis, evaluation, and treatment under the following condition: The physician must evaluate the patient and determine that he/she is mentally ill and because of this illness poses a likelihood of serious harm. The phrase likelihood of serious harm means substantial risk of physical harm to the person himself as manifested by evidence of threats of, or attempts at, suicide or serious bodily harm; or substantial risk of physical harm to other persons as manifested by evidence of homicidal or other violent behavior and serious physical harm to them.<sup>1</sup> The laws in most other states set forth similar criteria. Perr,<sup>2</sup>in a recent review of the historical evolution of the criteria for involuntary hospitalization, highlights the phenomenal fluctuations in the standards. The present emphasis on dangerousness to
Instantaneous and sudden deaths. Clinical and pathological differentiation in coronary artery disease
Authors: M. Friedman
Journal: JAMA (1973)

A study of 59 persons dying of coronary artery disease revealed that persons dying instantaneously differed from persons dying suddenly of coronary artery disease in that (1) they rarely experienced acute symptoms or exhibited acute signs before death; (2) more than one half died during or immediately after physical exertion; (3) their deaths appeared to result from a primary arrhythmia; and (4) their hearts rarely showed an acute lesion of any kind and frequently exhibited two old occluded coronary arteries or one old occluded, left anterior descending artery. These latter differences should permit angiographic detection of many persons prone to instantaneous death.
Cooperating JAK1 and JAK3 mutants increase resistance to JAK inhibitors
Authors: Lorraine Springuel, Tekla Hornakova, Elisabeth Losdyck, Fanny Lambert, Emilie Leroy, Stefan N. Constantinescu, Elisabetta Flex, Marco Tartaglia, Laurent Knoops, Jean-Christophe Renauld
Journal: Blood (2014)
Multifocal Hot Spots Demonstrated by Whole-Body 131I Scintigraphy and SPECT/CT After Transaxillary Endoscopic Thyroidectomy
Authors: Ho Seong Kim, Seok Hwi Kim, Jung Han Kim, Byung-Tae Kim, Kyung-Han Lee
Journal: Clinical Nuclear Medicine (2015)

A 35-year-old woman received open thyroidectomy for a thyroid nodule that was confirmed as papillary carcinoma. Whole-body 131I scintigraphy during thyroid ablation demonstrated high uptake in the thyroid bed and multiple focal hot spots in the thorax. SPECT/CT localized the hot spots to the right chest wall and axilla, as well as to the left chest wall. The surgeon recognized these sites to concur with the transaxillary tract used during endoscopic thyroidectomy for nodular hyperplasia 8 years previously. Thus, this case illustrates how thyroidal tissue fragments seeded during endoscopic thyroidectomy can be mistaken for thyroid cancer metastasis on 131I scintigraphy.
A social psychologist illuminates cognition
Authors: Amir Raz, Kim L. Norman
Journal: Behavioral and Brain Sciences (2004)

Sprinkled with humor, social psychology illuminates cognition in Wegner's beautifully written and cleverly crafted book. However, scantily exploiting such themes as psychopathology, development, and neural correlates of consciousness, Wegner's account does not fully project into cognitive neuroscience. Broaching the topic of self-regulation, we outline neurocognitive data supplementing the notion that voluntariness is perhaps more post hoc ascriptions than bona fide introspection.
Abstract 142: Novel tumor suppressor role of microRNA-205 in melanoma via regulation of E2F1
Authors: Altaf A. Dar, Shahana Majid, Mehdi Nosrati, David de Semir, Vladimir Bezrookove, Mohammed Kashani-Sabet
Journal: Cancer Research (2011)

Abstract MicroRNAs (miRNAs) regulate gene expression by repressing translation or directing sequence-specific degradation of complementary mRNA. Altered miRNA expression has been demonstrated in several human cancers. Limited information is available concerning the expression and role of miRNAs in melanoma. Here, we report that expression of miR-205 is significantly suppressed in melanoma tumor samples when compared with nevi, and is correlated inversely with melanoma progression. miR-205 expression was also significantly downregulated in a panel of melanoma cell lines when compared to a normal melanocyte line. miRNA target databases predicted a conserved target site for miRNA-205 in the 3’ untranslated region (UTR) of E2F1 and E2F5. The expression levels of E2F1 and E2F5 were inversely correlated with that of miR-205 in melanoma cell lines. miR-205 significantly suppressed the luciferase activity of reporter plasmids containing the 3’UTR sequences complementary to either E2F1 or E2F5, which was abolished by mutations in these 3’UTR regions. Overexpression of miR-205 in melanoma cells reduced E2F1 and E2F5 protein levels without alteration of mRNA expression. The proliferative ability of melanoma cells was suppressed by miR-205, mediated by E2F-regulated AKT phosphorylation. Transient overexpression of miR-205 in melanoma cells resulted in induction of apoptosis, as indicated by increases in cleaved caspase-3, poly-(ADP-ribose) polymerase (PARP) and release of cytochrome-c. Stable overexpression of miR-205 suppressed cell proliferation and colony formation, and resulted in inhibition of tumor cell growth in vivo and induction of a senescence phenotype accompanied by elevated p16INK4A expression and other markers for senescence. These results demonstrate a novel role for miR-205 as a tumor suppressor in melanoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 142. doi:10.1158/1538-7445.AM2011-142
A comparison of manual and automated methods of measuring airway resistance and thoracic gas volume.
Authors: P W Lord, A G Brooks
Journal: Thorax (1977)

An automated method of measuring airways resistance (Raw) and thoracic gas volume (Vtg) by whole body plethysmography using a digital computer is described. The results obtained by this method are compared with those obtained by an experienced observer and the results of consistency tests on the two methods are given. There was wide variability in the values of Raw obtained using each method, and no significant differences were found between the two methods. The values of Vtg obtained by them were highly correlated, but the results obtained manually were higher than those obtained automatically by an amount proportional to the volume. The consistency of the computer measurements was shown to be greater than that of the manual method. A significant decrease between successive measurements of Raw in some subjects was noted in the manual observations but not in those derived from the automated method. The new method is suitable for the rapid determination of Raw and Vtg.
THE SPREAD OF TUBERCULOSIS BY COUGHING.
Authors: L. NAPOLEON BOSTON
Journal: JAMA (1901)

The general opinion held by the medical profession at large has been that tuberculosis is disseminated chiefly by sputum, pus from tuberculous ulcers and sinuses, and from the dejecta of the bowel in persons or in animals suffering from tuberculous enteritis; these substances, from whatever source, becoming dry and later pulverized; they, together with their tubercle bacilli, are carried about by the currents of air. Such dust is commonly agitated by sweeping and dusting of carpets, rugs and furniture in rooms previously occupied by tuberculous patients. Indeed, the investigations of Cornet<sup>1</sup>go far to corroborate this popular belief. Cornet showed that dried sputum—dust—remained dangerous for months. He collected dust from the floors; walls and furniture of rooms previously occupied by persons suffering from pulmonary tuberculosis in various prisons, hospitals, asylums, and private dwellings, and, inoculating animals with such dusts, he determined the presence of virulent tubercle bacilli. Of the
Correspondence to the past: The essence of the archaeology metaphor
Authors: Steen F. Larsen
Journal: Behavioral and Brain Sciences (1996)

Abstract The correspondence view of memory is not a metaphor. However, correspondence is the essential feature of the archaeology metaphor, which harks back to Freud and Neisser. A modern version of this metaphor and some of its implications are briefly described. The archaeology metaphor integrates the idea of stored traces in a nonmechanistic framework.
Reading in Internal Medicine
Authors: RUSSELL M. WILDER
Journal: Annals of Internal Medicine (1976)

Comments and Corrections1 June 1976Reading in Internal MedicineRUSSELL M. WILDER, M.D., F.A.C.P.RUSSELL M. WILDER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-6-748 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The January issue of the "Annals" brings two clearly polarized messages that emphasize the longstanding split in internal medicine between humanism and technology.An editorial by Dr. Petersdorf underscores the need for more emphasis (in postgraduate educational programs in medicine) on ambulatory, continuing, and comprehensive care for adults. He goes on to describe, as what we do not need more of, the application of the technology of "big medicine." He raises "serious questions about the inhumanity that the advanced life support systems have brought with them" (1).A few pages later, Dr. Huth promises us relief of...References1. PETERSDORF R: Internal medicine 1976: consequences of sub-specialization and technology. Ann Intern Med 84:92-94, 1976 LinkGoogle Scholar2. EDITORIAL: Help for "intellectual indigestion." Ann Intern Med 84:97, 1976 LinkGoogle Scholar3. : Nephrology: an annotated bibliography of recent literature. References to journals and other paper. Ann Intern Med 84:104-109, 1976 LinkGoogle Scholar1. ROGERS D: On technologic restraint. Arch Intern Med 135: 1393-1397, 1975 CrossrefMedlineGoogle Scholar2. BEESON P: On becoming a clinician, in Textbook of Medicine, edited by BEESON PB, MCDERMOTT W. Philadelphia, W. B. Saunders, 1975, pp. 1-3 Google Scholar1. Report from the Boston Collaborative Drug Surveillance Program, Arch Intern Med 134:219-223, 1974 CrossrefMedlineGoogle Scholar2. CARANASOSSTEWARTCLUFF GRL: Drug-induced illness leading to hospitalization. JAMA 228:713-717, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Minneapolis VA Hospital Minneapolis, MN 55417 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1976Volume 84, Issue 6Page: 748-749 Issue Published: 1 June 1976 PDF DownloadLoading ...
Interferon beta 2/interleukin 6 modulates synthesis of alpha 1-antitrypsin in human mononuclear phagocytes and in human hepatoma cells.
Authors: D H Perlmutter, L T May, P B Sehgal
Journal: Journal of Clinical Investigation (1989)

The cytokine IFN beta 2/IL-6 has recently been shown to regulate the expression of genes encoding hepatic acute phase plasma proteins. INF beta 2/IL-6 has also been shown to be identical to MGI-2, a protein that induces differentiation of bone marrow precursor cells toward mature granulocytes and monocytes. Accordingly, we have examined the effect of IFN beta 2/IL-6 on expression of the IL-1- and tumor necrosis factor-unresponsive acute phase protein alpha 1-antitrypsin (alpha 1 AT) in human hepatoma-derived hepatocytes and in human mononuclear phagocytes. Purified human fibroblast and recombinant IFN beta 2/IL-6 each mediate a specific increase in steady-state levels of alpha 1 AT mRNA and a corresponding increase in net synthesis of alpha 1 AT in primary cultures of human peripheral blood monocytes as well as in HepG2 and Hep3B cells. Thus, the effect of IFN beta 2/IL-6 on alpha 1 AT gene expression in these cells is primarily due to an increase in accumulation of alpha 1 AT mRNA and can be distinguished from the direct, predominantly translational effect of bacterial lipopolysaccharide on expression of this gene in monocytes and macrophages. The results indicate that IFN beta 2/IL-6 regulates acute phase gene expression, specifically alpha 1 AT gene expression, in extrahepatic as well as hepatic cell types.
724-2 Electrophysiologic Endpoints of Successful Radlofrequency Catheter Modification for Atrioventricular Nodal Reentrant Tachycardia. Are There “Good” and “Bad” Persistent Echoes?
Authors: Anwer Dhala, Zalmen Blanck, Margaret Budziszewski, Michael Biehl, Sanjay Deshpande, Jasbir Sra, Mohammad R. Jazayeri, Masood Akhtar
Journal: Journal of the American College of Cardiology (1995)
Effect of tamoxifen on bone: Authors' reply
Authors: C D P Wright, J E Compston, R E Mansel, J-C Gazet
Journal: BMJ (1993)

poor fit of the distribution of free ( human chorionic gonadotrophin to a Gaussian model in the upper range.More data are required to clarify this, but our present conclusion is that with appropriate allowance for the poor fit, the same parameters2 yield an estimated difference in detection that may be as little as 1-2%.
The ‘inverted’ advancement and inferior rotation of the nasal sidewall (AIRNS) flap for defects of the medial canthus
Authors: R. Urwin, R. Montgomery, W. Hussain
Journal: British Journal of Dermatology (2013)

Funding sources: none. Conflicts of interest: none declared. Dear Editor, Within the periocular region, the medial canthus is a common site for occurrence of nonmelanoma skin cancers. As a result, numerous options for repairing surgical defects at this site have been promulgated. Indeed, recently in this journal, the utility of island pedicle flaps was highlighted for such defects.1 Although secondary intention healing may also produce excellent results for centrally located medial canthal wounds, for defects lying predominantly inferior to the lacrimal caruncle, active reconstruction either via a full‐thickness skin graft or local flap repair is warranted to minimize the risk of scar‐contraction‐induced ectropion. The advancement and inferior rotation of the nasal sidewall (AIRNS) flap has recently been used as an alternative to the bilobed flap for nasal tip defects.2 We have successfully employed an ‘inverted’ AIRNS flap for defects of the lower medial canthus in seven patients with excellent results (three male, four female; median age 62 years; average defect size 1·2 × 1·3 cm). As the name suggests, the inverted AIRNS flap mirrors the design of the originally described flap but is ‘upside down’, transferring skin in a superior direction from the cheek and nasal sidewall to the medial canthus (Fig. 1). When utilized to repair defects of the medial canthus, due to the concave topography of this region, a slight oversizing of the rotational limb of the flap is warranted to minimize the risk of tenting and to enable the flap to follow the contour of the area smoothly.
BCG vaccination against tuberculosis: international perspectives.
Authors: K M Citron
Journal: BMJ (1993)

infected with HIV or not.Mortality in these outbreaks has been high, and measures to control tuberculosis are therefore being urgently reviewed in the United States.In the Medical Research Council's surveys of notifications of tuberculosis in England and Wales in 1978-9,1983, and 1988,95% or more of initial isolates of M tuberculosis from respiratory specimens from previously untreated patients were fully sensitive to