tbuckley/cabot-search huggingface dataset:
Deletion of scavenger receptor A protects mice from progressive nephropathy independent of lipid control during diet-induced hyperlipidemia
Authors: Wenjian Wang, Bin He, Wei Shi, Xinling Liang, Jianchao Ma, Zhixin Shan, Zhaoyong Hu, Farhad R. Danesh
Journal: Kidney International (2012)

Scavenger receptor A (SR-A) is a key transmembrane receptor in the endocytosis of lipids and contributes to the pathogenesis of atherosclerosis. To assess its role in hyperlipidemic chronic kidney disease, wild-type and SR-A-deficient (knockout) mice underwent uninephrectomy followed by either normal or high-fat diet. After 16 weeks of diet intervention, hyperlipidemic wild-type mice presented characteristic features of progressive nephropathy: albuminuria, renal fibrosis, and overexpression of transforming growth factor (TGF)-β1/Smad. These changes were markedly diminished in hyperlipidemic knockout mice and attributed to reduced renal lipid retention, oxidative stress, and CD11c(+) cell infiltration. In vitro, overexpression of SR-A augmented monocyte chemoattractant protein-1 release and TGF-β1/Smad activation in HK-2 cells exposed to oxidized low-density lipoprotein. SR-A knockdown prevented lipid-induced cell injury. Moreover, wild-type to knockout bone marrow transplantation resulted in renal fibrosis in uninephrectomized mice following 16 weeks of the high-fat diet. In contrast, knockout to wild-type bone marrow transplantation led to markedly reduced albuminuria, CD11c(+) cell infiltration, and renal fibrosis compared to wild-type to SR-A knockout or wild-type to wild-type bone marrow transplanted mice, without difference in plasma lipid levels. Thus, SR-A on circulating leukocytes rather than resident renal cells predominantly mediates lipid-induced kidney injury.
Effects ofl-arginine on the systemic, mesenteric, and Hepatic circulation in patients with cirrhosis
Authors: Shigeru Kakumitsu, Hiroshi Shijo, Masanori Yokoyama, Tetsuhiro Kim, Nobuo Akiyoshi, Kazuhiro Ota, Katsuhiko Kubara, Makoto Okumura, Kazuhide Inoue
Journal: Hepatology (1998)

Nitric oxide (NO) is known to play an important role in modulating both the hepatic and mesenteric circulation under physiological and pathological conditions. We investigated how L-arginine, a precursor of NO, modifies the hepatic and mesenteric circulation in patients with cirrhosis. The study design was a single-blind controlled study. We measured the systemic and portal hemodynamics before and following intravenous L-arginine and saline infusion using pulsed Doppler ultrasonography in 20 patients with cirrhosis, and then the effects were compared with those found in 20 healthy subjects. In these patients, the effects of L-arginine on hepatic circulation were investigated using hepatic catheterization. L-Arginine infusion induced systemic vasodilation in both the healthy controls and the cirrhotic patients in a similar hemodynamic manner. In these patients, the L-arginine-induced increase in the portal flow was significantly higher than that of cardiac output (CO); however, the relation was the inverse in healthy subjects. Moreover, the L-arginine-induced increase in the portal flow was greater in the cirrhotic patients than that seen in healthy subjects. As a result, L-arginine infusion was thus found to selectively augment the hepatopetal portal blood flow in the cirrhotic liver. In patients, L-arginine infusion induced marked hepatic vasodilation as demonstrated by the reduced hepatic sinusoidal resistance (HSR) and increased estimated hepatic blood flow (EHBF) associated with the ameliorated intrinsic clearance of indocyanine green. Despite the fall in HSR, the hepatic venous pressure gradient (HVPG) increased following L-arginine infusion. The mesenteric and hepatic vascular areas of cirrhosis exhibited an increased susceptibility to the dilator action of L-arginine. These findings suggest that the enhanced NO production in the splanchnic vascular area has an important role in the hepatic circulation in patients with cirrhosis.
Gene array analysis and the liver
Authors: N Shackel
Journal: Hepatology (2002)

Functional genomics methods promise a previously unparalleled high-throughput examination of intrahepatic gene expression. Profiling transcriptomes as well as examining the coordinate expression of many genes in diverse pathobiologic pathways is now pssible with techniques such as gene array analysis. However, the nature of the hepatic transcriptome, limitations of the functional genomics methokologies used, and analysis of the data generated are often poorly understood. Further, the use of replicates during analysis and the downstream confirmation of results using a supplemental methokology are important but frequently neglected aspects of experimenta design. This review presents an overview of functional genomics methodoogies in the organ-specific context of studying intrahepatic gene expression. The focus of the review is the most widely used functional genomic methodology, gene array analysis. The nature of the hepatic transcriptome is discussed, together with a summary of gene array analysis methodologies. Analysis of data generated by gene array analysis, determination of intrahepatic cellular origin of transcript expression, and studies of intrahepatic gene expression using gene array analysis are also reviewed. Finally, the importance of a coordinate experimental approach examining both liver protein and mRNA expression is presented. (HEPATOLOGY 2002;36: 1313-1325).
SERUM URIC ACID IS ASSOCIATED WITH CENTRAL BLOOD PRESSURE INDEPENDENT OF SERUM C-PEPTIDE, RENAL FUNCTION, ARTERIAL STIFFNESS INDEX AND PERIPHERAL WAVE REFLECTION
Authors: Hsu Pai Feng, Shao-Yuan Chuang, Hao-Min Cheng, Wen-Chung Yu, Pesus Chou, Shih-Tzer Tsai, Chen-Huan Chen
Journal: Journal of the American College of Cardiology (2011)
Severe combined immunodeficiency mouse-human skin chimeras: a unique animal model for the study of psoriasis and cutaneous inflammation
Authors: S.P. Raychaudhuri, M. Sanyal, S.K. Raychaudhuri, S. Dutt, E.M. Farber
Journal: British Journal of Dermatology (2001)

Journal Article Severe combined immunodeficiency mouse–human skin chimeras: a unique animal model for the study of psoriasis and cutaneous inflammation Get access S.P. Raychaudhuri, S.P. Raychaudhuri Psoriasis Research Institute, 600 Town & Country Village, Palo Alto, CA 94301, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar M. Sanyal, M. Sanyal Psoriasis Research Institute, 600 Town & Country Village, Palo Alto, CA 94301, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar S.K. Raychaudhuri, S.K. Raychaudhuri Psoriasis Research Institute, 600 Town & Country Village, Palo Alto, CA 94301, U.S.A. Dr Siba P.Raychaudhuri, MD. E‐mail: raysiba@aol.com Search for other works by this author on: Oxford Academic Google Scholar S. Dutt, S. Dutt Psoriasis Research Institute, 600 Town & Country Village, Palo Alto, CA 94301, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar E.M. Farber E.M. Farber Psoriasis Research Institute, 600 Town & Country Village, Palo Alto, CA 94301, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 144, Issue 5, 1 May 2001, Pages 931–939, https://doi.org/10.1046/j.1365-2133.2001.04178.x Published: 01 May 2001
Psychodynamic Considerations of Hypochondriasis
Authors: Don R. Lipsitt
Journal: Psychotherapy and Psychosomatics (1974)

The term hypochondriasis must be considered, in its historical, medical and sociological context, as a label misused extensively – often as an expression of the physician's frustration, disappointment and anger when faced with an elusive diagnostic problem. Attempts at refinement of definition of terms such as hysteria, conversion reaction, somatization, psychophysiological and psychosomatic diseases are cited; yet the theoretical issues involved are often defiant of clarification and the problems in clinical differentiation remain complex. A case example of a 'hypochondriacal patient' illustrates the common clinical dilemmas experienced by patient, house staff and physicians, the iatrogenic components of dysfunctional doctor-patient relationships, and some of the psychodynamic mechanisms related to the patient's mode of presentation, illness behavior, and ultimate disclosure of intrapsychic as well as psychosocial problems.
Triple negative breast cancer phenotypes: a comparison between symptomatic and screening patients.
Authors: RK Johnson, JH Winstanley, F Corcoran, M Pearson
Journal: Cancer Research (2009)

Abstract Abstract #2085 Body: Background: Triple-negative breast cancers are defined by a lack of expression of oestrogen, progesterone, and HER-2 receptors. Prognostically, they are associated with a poor clinical outcome. It is uncertain whether during growth and maturation of a breast cancer its phenotype may drift from one which over-expresses ER, PR and HER-2 towards a tumor type that loses this expression. In the UK women are screened for breast cancer between the ages of 50 and 70 years, which provides us with a cohort of patients whose breast cancers are at a much earlier stage than those presenting symptomatically. Thus if phenotypic drift occurred the screening population might have a lower incidence of triple negative tumors compared to those presenting symptomatically.&amp;#x2028; Aim: To compare the incidence of triple negative tumors in a screening and symptomatic population. Materials and Methods: Pathology reports for 2002 to 2004 inclusive were scrutinized for ER PR and HER-2 expression. A list of screening patients was retrieved from our screening database and cross-referenced with pathology reports. Immunohistochemistry (IHC) was used to quantify ER and PR expression, a quick score of 4 or less was negative for over-expression. Similarly IHC was used to quantify HER-2 expression, and a score of 0 or 1+ was negative for over-expression. clinical data, such as patient age, lymphovascular invasion, lymph node status, tumor size, and grade were available for statistical analysis. Results: There were 213 screening patients of which, 31 (14.5%) had triple negative phenotypes and 443 symptomatic patients of which, 73 (16.4%) were triple negative. This difference was not statistically different. Discussion: The incidence of Basal-like breast tumors is similar in the screening group compared to the symptomatic population suggesting that this aspect of tumor biology is determined at a very early stage in the development of tumors and is not subject to phenotypic drift. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 2085.
Further Observations on the Occurrence of Streptococci of Groups Other Than a in Human Infection
Authors: George E. Foley
Journal: New England Journal of Medicine (1947)

THE occurrence of streptococci of groups other than A is rare in upper respiratory infections such as scarlet fever, tonsillitis and septic sore throat. These streptococci, however, are frequently isolated from sporadic infections, including septic abortion (Hare,1 1937), puerperal fever (Fry,2 1938), meningitis (Rantz,3 1942), urinary infections (Porch,4 1941), subacute bacterial endocarditis (Wheeler and Foley,5 1945) and miscellaneous conditions (Wheeler and Foley,6 1943). The predominant role of Group A streptococci in the over-all pattern of streptococcal disease in man is not disputed. The intention of the present communication is to re-emphasize the potential significance of the streptococci of groups other . . .
Gallium-positive Lyme Disease Myocarditis
Authors: LAURENCE I. ALPERT, PETER WELCH, NEIL FISHER
Journal: Clinical Nuclear Medicine (1985)

In the course of a work-up for fever of unknown origin associated with intermittent arrhythmias, a gallium scan was performed which revealed diffuse myocardial uptake. The diagnosis of Lyme disease myocarditis subsequently was confirmed by serologic titers. One month following recovery from the acute illness, the abnormal myocardial uptake completely resolved.
Very short duration therapy with oral terbinafine for fingernail onychomycosis
Authors: C.-K. Wong, Y.-L. Cho
Journal: British Journal of Dermatology (1995)

Journal Article Very short duration therapy with oral terbinafine for fingernail onychomycosis Get access C.‐K. Wong, C.‐K. Wong Department of Dermatology, Veterans General Hospital‐Taipei, and National Yang‐Ming University, Taipei Taiwan Search for other works by this author on: Oxford Academic Google Scholar Y.‐L. Cho Y.‐L. Cho Department of Dermatology, Veterans General Hospital‐Taipei, and National Yang‐Ming University, Taipei Taiwan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 133, Issue 2, 1 August 1995, Pages 329–331, https://doi.org/10.1111/j.1365-2133.1995.tb02644.x Published: 01 August 1995
Antibody Response and Systemic Reactions after Inoculation of a New Type of T.A.B.C. Vaccine
Authors: A. Felix, S. G. Rainsford, E. J. Stokes
Journal: BMJ (1941)

LIMB COMPRESSION ENDING FATALLY IN URAEMIA MEBARITISNAL 435 proteins (from 6.4 to 4.8-see table ), and since no diuresis had ensued, this was abandoned.Mersalyl 1 c.cm. was injected intramuscularly on October 31, and a similar dose intravenously on November 2. Table Correlating the Treatment, Blood Pressure, Urine Excretion anid Blood Estimations Blood Ham-Plasma Blood Urea Hb Hacma-Protein Urine Date Pressure mg.% gin.Treatment Out-perl100 R.B.C
Is Phthisis Communicable?
Authors: Alex. Paterson
Journal: BMJ (1883)

Seneca Valley virus (SVV), a newly emerging virus belonging to the <i>Picornaviridae</i> family, has caused vesicular disease in the swine industry. However, the molecular mechanism of viral pathogenesis remains poorly understood. This study revealed that SVV infection could induce pyroptosis in SK6 cells in a caspase-dependent and -independent manner. SVV may inhibit caspase-1 activation at late infection because of 3C<sup>pro</sup> cleavage of NLRP3, which counteracted pyroptosis activation. Further study showed that 3C<sup>pro</sup> targeted porcine gasdermin D (pGSDMD) for cleavage through its protease activity. 3C<sup>pro</sup> cleaved porcine GSDMD (pGSDMD) at two sites, glutamine 193 (Q193) and glutamine 277 (Q277), and Q277 was close to the caspase-1–induced pGSDMD cleavage site. pGSDMD<sub>1–277</sub> triggered cell death, which was similar to N-terminal fragment produced by caspase-1 cleavage of pGSDMD, and other fragments exhibited no significant inhibitory effects on cellular activity. Ectopic expression of pGSDMD converted 3C<sup>pro</sup>-induced apoptosis to pyroptosis in 293T cells. Interestingly, 3C<sup>pro</sup> did not cleave mouse GSDMD or human GSDMD. And, both pGSDMD and pGSDMD<sub>1–277</sub> exhibited bactericidal activities in&nbsp;vivo. Nevertheless, pGSDMD cannot kill bacteria in&nbsp;vitro. Taken together, our results reveal a novel pyroptosis activation manner produced by viral protease cleavage of pGSDMD, which may provide an important insight into the pathogenesis of SVV and cancer therapy.
RISK OF STROKE AND DEATH IN PATIENTS WITH SYMPTOMATIC CEREBROVASCULAR DISEASE UNDERGOING HEART TRANSPLANTATION: AN ANALYSIS OF THE UNITED NETWORK FOR ORGAN SHARING REGISTRY
Authors: Vishnu Patlolla, Vanajakshi Mogulla, Benjamin Kalsmith, David DeNofrio, Rajan Krishnamani
Journal: Journal of the American College of Cardiology (2010)
Anthony John Pearce
Authors: M. Bright
Journal: BMJ (2002)

Former consultant anaesthetist Newmarket General Hospital and Addenbrooke's Hospital, Cambridge (b Kew 1932; q Middlesex Hospital 1959; FRCA, DA, DObst RCOG), died from prostate cancer on 24 May 2002.

John trained in Kettering and Cambridge before his appointment as consultant. During his later training and early consultant career his wife was seriously ill and he had to care for his young children during her frequent admissions to hospital. He would accept only his full share of departmental duties, even after Iris's death in the most tragic circumstances. His particular interests were obstetric anaesthesia and analgesia, but he was also involved in ophthalmology and plastic surgery. Riding was one of John's leisure pursuits and he competed three times in the Newmarket Town Plate. He leaves his second wife, Kim; two children; and a grandson.
Transmural heterogeneity of postjunctional 2 adrenergic coronary vasoconstriction in hypoperfused cat left ventricle
Authors: J. Westby, S. Birkeland, J. Lekven, K. Grong
Journal: Cardiovascular Research (1992)

Journal Article Transmural heterogeneity of postjunctional α2 adrenergic coronary vasoconstriction in hypoperfused cat left ventricle Get access Joergen Westby, Joergen Westby Surgical Research Laboratory, Department of Surgery, University of Bergen, Haukeland Hospital, N-5021 Bergen, Norway Correspondence to Dr Westby. Search for other works by this author on: Oxford Academic PubMed Google Scholar Sigurd Birkeland, Sigurd Birkeland Surgical Research Laboratory, Department of Surgery, University of Bergen, Haukeland Hospital, N-5021 Bergen, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar Jon Lekven, Jon Lekven Surgical Research Laboratory, Department of Surgery, University of Bergen, Haukeland Hospital, N-5021 Bergen, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar Ketil Grong Ketil Grong Surgical Research Laboratory, Department of Surgery, University of Bergen, Haukeland Hospital, N-5021 Bergen, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 3, March 1992, Pages 279–284, https://doi.org/10.1093/cvr/26.3.279 Published: 01 March 1992 Article history Received: 17 June 1991 Accepted: 23 September 1991 Published: 01 March 1992
Lack of Effect of Promoter, Coding and 3′ Polymorphisms of the β2-adrenergic Receptor (ADRB2) on the Clinical Response to Salmeterol Alone or with Fluticasone Propionate in Subjects with Asthma
Authors: W ANDERSON, E BLEECKER, H NELSON, J CORREN, A EMMETT, D REILLY, S YANCEY, H ORTEGA
Journal: Journal of Allergy and Clinical Immunology (2008)
Liver cell dysplasia and hepatocellular carcinoma: Non-A, non-B hepatitis, too?
Authors: Cynthia Cohen
Journal: Hepatology (1987)

Liver cell dysplasia (LCD) is a premalignant cytologic change of hepatocytes that has been statistically linked to cirrhosis, hepatocellular carcinoma (HCC), and chronic liver disease related to hepatitis B virus. The relationship of LCD to non-A, non-B (NANB) hepatitis is currently unknown. We studied liver biopsy and surgical resection specimens from 36 patients with NANB hepatitis, and identified LCD in 17 (42.5%) of 40 specimens, most often associated with cirrhosis. Dysplasia was present in individual hepatocytes, in clusters, and in a distinctive “spreading” pattern of hepatocytes about central veins. Three patients had HCC with a predominant giant cell pattern, as well as LCD. These findings suggest that LCD and HCC should be included among the potential pathologic sequelae of NANB hepatitis.
Is Methotrexate Therapy for Psoriasis Carcinogenic?
Authors: Philip L. Bailin
Journal: JAMA (1975)

The use of methotrexate in psoriasis has recently been questioned because of possible carcinogenic potential. Two hundred twenty-four patients began methotrexate therapy during 1960 to 1965 at the Cleveland Clinic and at Duke University Medical Center. The incidence of malignant neoplasms and mortality has been studied in 205 of these 224 patients. Mortality increased with hepatic disease. No increased incidence of total internal malignancy was found, nor did any one type of neoplasm appear predominant. (<i>JAMA</i>232:359-362, 1975)
Comparison of Left Ventricular Ejection Fraction By EKG-Gated Radionuclide Techniques and Contrast Angiography Using a Microcomputer System
Authors: ROBERT DURNIN, ROBERT HENDERSON, DONALD LOGAN, DANIEL DANAHY, KAY BARRETT, TAMNIT ANSUSINHA
Journal: Clinical Nuclear Medicine (1979)

The left ventricular ejection fractions of 53 patients were determined from multi-image cardiac blood pool scintigrams in the left anterior oblique position utilizing a microcomputer and floppy disc. These date were compared to ejection fractions obtained at cardiac catheterization in the right anterior oblique position. The ejection fraction obtained by radionuclide technique was comparable to that obitained by contrast angiography in the 53 patients with an r = 0.93. Forty-five patients with coronary artery disease showed an r = 0.92. In the coronary artery group with regional wall dysfunction, the correlation was r = 0.89.
Meniscus Lesions: Practical Problems of Clinical Diagnosis, Arthrography and Therapy
Authors: Reginald R. Cooper
Journal: JAMA (1971)

Readability, preciseness, and superb photography embodied in this brief treatise demand the attention of any serious student of knee arthrography. Two radiologists and a surgeon combine their talents and correlate their findings in an enlightening manner. Although the initial chapters contain a brief review of knee anatomy and a lucid and informative discussion of pathogenesis and diagnosis of meniscal lesions, the much larger section on arthrography almost completely dominates them. Perhaps arthrography should be the primary title of this book. Numerous outstanding radiographs attest to a meticulous mastery of double-contrast arthrography. Such technique, undoubtedly developed after numerous procedures, yields dividends in the form of diagnostic aid in equivocal knee problems. Profuse illustrations depict prime examples of various meniscal lesions and numerous other knee disorders. Well-defined indications and a discussion of complications and errors place arthrography in proper perspective and remind the reader that a careful history and physical examination in