tbuckley/cabot-search huggingface dataset:
Delivering Bad News
Authors: Turner A. Wood
Journal: JAMA (1996)

<h3>To the Editor.</h3> —As a medical oncologist, I frequently participate in breaking various types of bad news, so I appreciated the article by Dr Ptacek and Ms Eberhardt.<sup>1</sup>One point that deserves emphasis is to be sure of the information before it is delivered to the patient. The diagnosis, extent of involvement, and treatment plan must be as clear as possible before breaking the news. The following anecdote will illustrate my point. A young woman presented with abdominal pain. Abdominal computed tomographic scan showed a large gastric mass with extensive involvement of liver, spleen, and lymph nodes. At the gastroscopy, a tumor was biopsied, and the initial verbal report from the pathologist was lymphoma. The family physician broke the bad news and discussed treatment and prognosis of lymphoma optimistically. The oncologist (me) saw the patient the next day. At that time, additional study by the pathologist led to a verbal diagnosis of
Lovastatin increases arachidonic acid levels and stimulates thromboxane synthesis in human liver and monocytic cell lines.
Authors: N Hrboticky, L Tang, B Zimmer, I Lux, P C Weber
Journal: Journal of Clinical Investigation (1994)

The effect of lovastatin (LOV), the inhibitor of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, on linoleic acid (LA, 18:2n-6) metabolism was examined in human monocytic Mono Mac 6 (MM6) and hepatoma Hep G2 cells. The desaturation of LA was examined after LOV (72 h, 10 microM) or dimethylsulfoxide (LOV carrier, < 0.1%) and [14C]LA (last 18 h, 0.3 microCi, 5 microM). In both cell lines, LOV reduced the percentage of 14C label associated with LA and increased the percentage of label in the 20:4n-6 and the 22:5n-6 fractions. In Hep G2 but not MM6 cells, this effect was fully reversible by means of coincubation with mevalonic acid (500 microM), but not with cholesterol or lipoproteins. In both cell lines, the LOV-mediated increase in LA desaturation resulted in dose-dependent reductions of LA and elevations of AA in cellular phospholipids. The lipids secreted by LOV-treated Hep G2 cells were also enriched in arachidonic acid (AA). In the MM6 cells, LOV increased release of thromboxane upon stimulation with the calcium ionophore A23187. In summary, our findings of higher LA desaturation and AA enrichment of lipids secreted by the Hep G2 cells suggest that LOV treatment may increase the delivery of AA from the liver to extrahepatic tissues. The changes in membrane fatty acid composition can influence a variety of cellular functions, such as eicosanoid synthesis in monocytic cells. The mechanism appears to be related to the reduced availability of intermediates of cholesterogenesis.
Circulation Time in the Aged
Authors: Hyman Levy
Journal: JAMA (1963)

<h3>To the Editor:—</h3> The experience in circulation time measurements in the aged varies from author to author. In a recentJournalarticle, "Circulation Time in the Aged," (<i>JAMA</i><b>183</b>:1037 [March 23] 1963) values up to 27 sec (mean, 19.5 sec) were found in normal men without roentgenologic evidence of cardiac enlargement or other objective sign of cardiac disease. In a recent study (<i>J Mount Sinai Hosp NY</i><b>30</b>:15, 1963) I employed the intravenous sodium dehydrocholate (Decholin) method to determine circulation time in a group of men and women with established coronary heart disease. Included in this study were 12 men, aged 69 to 73 (average, 71), showing circulation time values ranging from 14 to 22.5 sec (mean, 17 sec). The discrepancy between the mean values of 17 and 19.5 sec in the two studies referred to becomes all the more significant with the realization that in my own
RNA Editing of the IQ Domain in Cav1.3 Channels Modulates Their Ca2+-Dependent Inactivation
Authors: Hua Huang, Bao Zhen Tan, Yiru Shen, Jin Tao, Fengli Jiang, Ying Ying Sung, Choon Keow Ng, Manfred Raida, Georg Köhr, Miyoko Higuchi, Hadi Fatemi-Shariatpanahi, Bradley Harden, David T. Yue, Tuck Wah Soong
Journal: Neuron (2012)
Cirrhosis, bile acids and gut microbiota
Authors: Jason M Ridlon, Joao Marcelo Alves, Phillip B Hylemon, Jasmohan S Bajaj
Journal: Gut Microbes (2013)

A picture is now starting to emerge regarding the liver-bile acid-microbiome axis. Increasing levels of the primary bile acid cholic acid (CA) causes a dramatic shift toward the Firmicutes, particularly Clostridium cluster XIVa and increasing production of the harmful secondary bile acid deoxycholic acid (DCA). During progression of cirrhosis, the microbiome, both through their metabolism, cell wall components (LPS) and translocation lead to inflammation. Inflammation suppresses synthesis of bile acids in the liver leading to a positive-feedback mechanism. Decrease in bile acids entering the intestines appears to favor overgrowth of pathogenic and pro-inflammatory members of the microbiome including Porphyromonadaceae and Enterobacteriaceae. Decreasing bile acid concentration in the colon in cirrhosis is also associated with decreases in Clostridium cluster XIVa, which includes bile acid 7α-dehydroxylating bacteria which produce DCA. Rifaximin treatment appears to act by suppressing DCA production, reducing endotoxemia and harmful metabolites without significantly altering microbiome structure. Taken together, the bile acid pool size and composition appear to be a major regulator of microbiome structure, which in turn appears to be an important regulator of bile acid pool size and composition. The balance between this equilibrium is critical for human health and disease.
Important Elements of Outpatient Care: A Comparison of Patients' and Physicians' Opinions
Authors: Christine Laine
Journal: Annals of Internal Medicine (1996)

Objective: To compare patients' and physicians' opinions on the importance of discrete elements of health care as determinants of the quality of outpatient care. Design: Analysis of results of a mailed survey. Setting: Community-based internal medicine practices. Participants: 74 general internists and 814 patients randomly selected from the practices of these internists. Measures: 125 elements of care that covered nine domains were identified: physician clinical skill, physician interpersonal skill, support staff, office environment, provision of information, patient involvement, nonfinancial access, finances, and coordination of care. Participants rated each element on its importance to high-quality care on a 4-point scale: 1 = not important; 2 = of medium importance; 3 = of high importance; and 4 = essential. Patients' and physicians' ratings were compared for individual elements of care and for elements aggregated into domains. Results: Survey response rates were 93% for physicians and 60% for patients. In an element-by-element comparison of ratings, ratings by the two groups differed substantially for 58% of the attributes. The most striking difference was seen in the domain of provision of information (median ratings, 3.56 for patients and 2.85 for physicians; P < 0.001). Ratings by the two groups also differed in the domains of clinical skill (3.75 for patients and 3.35 for physicians; P < 0.001), nonfinancial access (3.00 for patients and 2.87 for physicians; P < 0.001), and finances (3.00 for patients and 2.80 for physicians; P = 0.006). When relative rankings of the domains were compared, both groups agreed that clinical skill is most important; however, patients ranked provision of information second in importance whereas physicians ranked it sixth. Conclusions: Patients and physicians agreed that the most crucial element of outpatient care is clinical skill, but they disagreed about the relative importance of other aspects of care, particularly effective communication of health-related information. These differences in perception may influence the quality of interactions between physicians and patients.
Bone tissue growth enhancement by calcium phosphate coatings on porous titanium alloys: The effect of shielding metal dissolution product
Authors: Paul Ducheyne, Paul D. Bianco, Cheolsang Kim
Journal: Biomaterials (1992)

The possible mechanism of minimization of prosthesis-derived bone growth inhibitors by shielding of the metal and the reduction, if not elimination, of the associated metal dissolution was investigated. Titanium, aluminium and vanadium release rates were determined in vitro for Ti alloy specimens both with and without a calcium phosphate coating. Ti orderly oriented wire mesh (OOWM) porous coatings on Ti-6AI-4V substrates were used as the metal specimens. Half of the specimens were coated with a 75 μm calcium phosphate ceramic (CPC coating). Seven reference (OOWM) and seven coated (OOWM-CPC) specimens were immersed and placed along with seven control solutions for various periods in an incubator maintained at 37°C and 5% CO2 — air atmosphere. Whereas the reference solutions showed a Ti release increasing as a function of time, the solutions that had the CPC-coated specimens contained no measurable amounts of titanium. The AI in solution around the CPC-coated specimens was significantly greater than the concentration around non-coated specimens. The AI, however, did not increase significantly with time, at least up to 4 wk immersion. The ceramic coating had a small beneficial effect on V concentration. In the absence of a significant adverse effect of Ti on local bone tissue formation, we focus on the AI data of our study. The possible adverse effect of this element is well documented. The calcium phosphate coating produced a significant increase of biological fixation, yet at the same time a greater AI release into solution, calling into question the value of CPC coating in shielding adverse metal passive dissolution to enhance bone growth.
Impact of multimedia on teaching basic cricket rules
Authors: Ramu Pilli
Journal: British Journal of Sports Medicine (2010)

Today's classroom practices are quite different from those of yesterday. Similarly, the classroom practices in the coming century may be quite different from those of today. The shape of future school, colleges and universities is bound to change radically due to technological impact in the years to come. Multimedia means making appeal to different senses instead of one as in the traditional method. Multimedia includes high technology instructional media. The present study was to investigate the role of multimedia on teaching basic cricket rules of ML Jai Simha and Bhavan's Cricket Academy specialisation students. Forty students studying bachelor's degree in the various colleges in Hyderabad, Andhra Pradesh, India. Represented under-19 years for Hyderabad Cricket Association, with the age from 18 to 20 years (mean age = 19±0.5 years) were selected for this study. They were divided into two groups of 20 subjects each namely the traditional practical method of teaching group and multimedia based modular of teaching group (teaching cricket rules). A computer expert was consulted to develop the courseware programme to teach the basic cricket rules and it was discussed with him how to develop software based on the modules. The achievement test consisted of 100 questions. Out of 100 questions, 60 objective type questions and 40 fill in the blanks type questions were present. The total score of the test was 100. For each correct answer, the score was one and for each wrong answer the score was zero. The statistical tool used for this study was ‘t’-ratio. The results of the study shows that the mean values of traditional lecture method of teaching group and multimedia based modular method of teaching group were 50.75 ± 2.89 and 70.25 ± 2.998, respectively. The obtained ‘t’-ratio value 20.61 greater than the require table value 2.0246 for significance at 0.05 level of confidence with df 38. The results of the study showed that there was a significant difference between traditional lecture method of teaching group and multimedia based modular method of teaching group in teaching cricket rules in favour of experimental group.
Abstract 9262: Prognostic Value of Myocardial Viability by Delayed Enhanced MR in Patients with Coronary Artery Disease and Low Ejection Fraction. Impact of Revascularization Therapy
Authors: Bernhard L Gerber, Michel Rousseau, Sylvie A Ahn, Jean-Benoît le Polain de Waroux, Anne-Catherine Pouleur, David Vancraeynest, Agnès Pasquet, Jean-Louis Vanoverschelde
Journal: Circulation (2011)

Background. Prior works showed that delayed-enhanced cardiac magnetic resonance (DE-cMR) predicts recovery of left ventricular dysfunction (LVD) after revascularization in coronary artery disease (CAD). We sought to evaluate impact of myocardial viability assessment by DE-cMR and of revascularization therapy on survival of patients (pts) with low ejection fraction (EF). Methods and Results. We prospectively evaluated survival of 144 consecutive pts (130 males, 65±11 years) with CAD and LVD (EF 24±7%) undergoing DE-cMR. 86 pts underwent complete revascularization of dysfunctional myocardium (79 CABG, 7 PCI), while 58 pts remained under medical treatment. Pts were considered to have viable myocardium if &gt;4 dysfunctional segments had &lt;50% transmurality of DE. Over 3-years median follow-up 49 pts died. 3-year survival was significantly worse in pts with dysfunctional viable myocardium remaining under medical treatment (48%) than in medically treated pts with non-viable myocardium (77%, p=0.02 by log-rank test). By contrast, in revascularized pts, survival was similar whether myocardium was viable or not (88 and 71% survival respectively, p=NS). Hazard of death of medically treated viable myocardium was 4.56 [95% CI 1.93-10.8]. Cox multivariate analysis indicated that interaction of revascularization and viability provided significant additional value (X2=13.1, p=.004) to baseline predictors of survival (NYHA class, wall motion score and peripheral arterial disease). More importantly, in 43 pairs of propensity score matched pts for treatment selection, hazard of death (2.5 [95% CI 1.1-6.1, p=0.02]) remained significantly higher for medically treated rather than revascularized viable myocardium (Figure). Conclusions. Without revascularization, presence of viable myocardium by DE-cMR is an independent predictor of mortality in pts with ischemic LVD. This observation may be useful for preoperative selection of pts for revascularization.
An acquired inhibitor to factor VIIIC in a non‐hemophiliac: Twenty years of observation and characterization
Authors: Macie C. Coots, Helen I. Glueck
Journal: American Journal of Hematology (1987)

Abstract A non‐hemophilic patient with an acquired inhibitor to factor VIIIC was initially diagnosed in this laboratory 20 years ago at age 63. Following its initial appearance in 1963, the inhibitor was detectable on two other occasions. We believe that this is the longest duration such an inhibitor has persisted. No sample remained from his initial admission; however, samples were available from the last 8 years of his life for retrospective study. Preparative isofocusing, affinity chromatography, and immunoglobulin subtyping were used to determine the similarities and/or differences in the inhibitor over these 8 years. The following similarities and differences were observed in both the 1975 and 1983 plasmas. Isofocusing showed that both plasmas contained peaks of inhibitory activity with pIs of 7.25, 8.26, and 8.88; the 1975 sample in addition contained two peaks with pIs of 7.77 and 9.45, whereas two other peaks with pIs of 7.64 and 7.85 were found in the 1983 sample. For the final characterization, each isofocused inhibitory peak was eluted from Protein A Sepharose and incubated with antisera to determine the immunoglobulin subtype. Each peak consisted of mixtures of IgG 1 and IgG 4 with both kappa and lambda light chains. It was concluded that the inhibitor was polyclonal, based on the presence of inhibitory peaks with different pIs and immunoglobulin subtypes. These findings support the conclusion that the development of and changes in the inhibitor was a dynamic process with some inhibitors (antibodies) persisting, while at the same time others with different characteristics were being formed.
A System to Provide and Teach Comprehensive Medical Care
Authors: W. R. Miller
Journal: JAMA (1964)

A system to provide and teach comprehensive medical care, developed within the framework of a large cooperative outpatient department for medically indigent patients, has been in operation since Sept 1, 1962. The system, built on high ideals of medical practice and education, has been well received by staff physicians, interns, residents, nurses, patients, hospitals, and community agencies. This pioneering demonstration project, incorporating the most specialized health services in a modern community, may provide a pattern for development of similar programs in other localities.
A prospective study of congenital melanocytic naevi: progress report and evaluation after 6 years
Authors: H.A. DAWSON, D.J. ATHERTON, B. MAYOU
Journal: British Journal of Dermatology (1996)

Journal Article A prospective study of congenital melanocytic naevi: progress report and evaluation after 6 years Get access H.A. DAWSON, H.A. DAWSON St John's Dermatology Centre, St Thomas' Hospital. London SE1 7EH, U.K Search for other works by this author on: Oxford Academic Google Scholar D.J. ATHERTON, D.J. ATHERTON St John's Dermatology Centre, St Thomas' Hospital. London SE1 7EH, U.K ; Dr D.J. Atherton Search for other works by this author on: Oxford Academic Google Scholar B. MAYOU B. MAYOU St John's Dermatology Centre, St Thomas' Hospital. London SE1 7EH, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 134, Issue 4, 1 April 1996, Pages 617–623, https://doi.org/10.1111/j.1365-2133.1996.tb06959.x Published: 01 April 1996 Article history Accepted: 26 June 1995 Published: 01 April 1996
Ocular Toxic Effects of Fenretinide
Authors: Manuel R. Modiano, William S. Dalton, Scott M. Lippman, Leonard Joffe, Ann R. Booth, Frank L. Meyskens
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Ocular Toxic Effects of Fenretinide Get access Manuel R. Modiano, Manuel R. Modiano Search for other works by this author on: Oxford Academic PubMed Google Scholar William S. Dalton, William S. Dalton Search for other works by this author on: Oxford Academic PubMed Google Scholar Scott M. Lippman, Scott M. Lippman Search for other works by this author on: Oxford Academic PubMed Google Scholar Leonard Joffe, Leonard Joffe Search for other works by this author on: Oxford Academic PubMed Google Scholar Ann R. Booth, Ann R. Booth Search for other works by this author on: Oxford Academic PubMed Google Scholar Frank L. Meyskens Frank L. Meyskens Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 12, 20 June 1990, Page 1063, https://doi.org/10.1093/jnci/82.12.1063 Published: 20 June 1990 Article history Received: 16 April 1990 Accepted: 17 April 1990 Published: 20 June 1990
Why not add methionine to paracetamol tablets?
Authors: P J Neuvonen, O Simell, O Tokola
Journal: BMJ (1986)

while considered to be reduced.It formed a faecal fistula, which eventually closed spontaneously.Thus our use of the term Richter's hernia to describe ischaemic damage to only part of the circumference ofthe bowel wall after unrecognised incomplete reduction of a hernia seems to be historically correct.
Results of a 2-Stage, Phase 3 Pivotal Trial, EDEMA3®: A Study of Subcutaneous DX-88 (Ecallantide), a Plasma Kallikrein Inhibitor, in Patients with Hereditary Angioedema (HAE)
Authors: R LEVY, D MCNEIL, H LI, F HSU, P HORN, J ROBERTS
Journal: Journal of Allergy and Clinical Immunology (2008)
Hyaluronic acid-based hydrogels functionalized with heparin that support controlled release of bioactive BMP-2
Authors: Gajadhar Bhakta, Bina Rai, Zophia X.H. Lim, James H. Hui, Gary S. Stein, Andre J. van Wijnen, Victor Nurcombe, Glenn D. Prestwich, Simon M. Cool
Journal: Biomaterials (2012)
Doctors at Lunch
Authors: John L. Wright
Journal: Annals of Internal Medicine (1993)

Ad Libitum1 August 1993Doctors at LunchJohn L. Wright, MDJohn L. Wright, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-3-199308010-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I knew something went wrong that dayJerry told us doctors at lunchhe hadn't enjoyed Costa Rica. After all,trailblazer is his part in our daysdialyzing nephrons, skiing Crystal,priming the Staff for peer review.Most Wednesdays, he scales a Cascade.a second debulking, ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1993Volume 119, Issue 3Page: 245KeywordsBrainChartsDrugsGlioblastoma multiformeMedicareNephronsPeer reviewTheft ePublished: 15 August 2000 Issue Published: 1 August 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Origin and Employment of the Medical Graduates of the University of Aberdeen 1931-69
Authors: D. Ogston, W. D. Ogston, C. M. Ogston
Journal: BMJ (1970)

A survey was made of the medical graduates of the University of Aberdeen, 1931-69. The recent increase of graduates of non-British origin, the continuing high intake of women and their subsequent attrition, and the high rate of emigration, have combined to reduce substantially the number of these graduates working in Britain.