tbuckley/cabot-search huggingface dataset:
Mouse model of arterial injury.
Authors: V Lindner, J Fingerle, M A Reidy
Journal: Circulation Research (1993)

In the present study, we established an injury model of the mouse carotid artery. Complete removal of the endothelium was achieved with a flexible wire. A platelet monolayer covered the denuded surface, and damage to underlying medial smooth muscle cells (SMCs) was detected. Injection of [3H]thymidine was used to determine the replication index for medial SMCs, which was found to be 1.6% at 2 days after denudation and 9.8% at 5 days. SMCs were observed in the intima by day 8 (replication index, 66%), and by 2 weeks the intimal lesion had a similar cell content as the media. In most animals, repair of the endothelial lining was complete 3 weeks after injury. The present model will allow us to use transgenic animals to address questions relevant to vascular biology and atherosclerosis.
Biomarker-Based Predictive Models for Prognosis in Amyotrophic Lateral Sclerosis
Authors: Xiaowei William Su, Zachary Simmons, Ryan Michael Mitchell, Lan Kong, Helen Elizabeth Stephens, James Robert Connor
Journal: JAMA Neurology (2013)

<h3>Importance</h3> Although median survival in amyotrophic lateral sclerosis (ALS) is 2 to 4 years, survival ranges from months to decades, creating prognostic uncertainty. Strategies to predict prognosis would benefit clinical management and outcomes assessments of clinical trials. <h3>Objective</h3> To identify biomarkers in plasma and cerebrospinal fluid (CSF) of patients with ALS that can predict prognosis. <h3>Design, Participants, and Setting</h3> We conducted a retrospective study of plasma (n = 29) and CSF (n = 33) biomarkers identified in samples collected between March 16, 2005, and August 22, 2007, from patients with ALS at an academic tertiary care center. Participants included patients who were undergoing diagnostic evaluation in the neurology outpatient clinic and were eventually identified as having definite, probable, laboratory-supported probable, or possible ALS as defined by revised El-Escorial criteria. All were white and none had a family history of ALS. Clinical information extended from initial presentation to death. Genotyping for hemochromatosis (<i>HFE</i>) gene status was performed. Multiplex and immunoassay analysis of plasma and CSF was used to measure levels of 35 biomarkers. Statistical modeling was used to identify biomarker panels that could predict total disease duration. <h3>Main Outcomes and Measures</h3> Total disease duration, defined as the time from symptom onset to death, was the main outcome. The hypothesis being tested was formulated after data collection. <h3>Results</h3> Multivariable models for total disease duration using biomarkers from plasma, CSF, and plasma and CSF combined incorporated 7, 6, and 6 biomarkers to achieve goodness-of-fit<i>R</i><sup>2</sup>values of 0.769, 0.617, and 0.962, respectively. After classification into prognostic categories, actual and predicted values achieved moderate to good agreement, with Cohen κ values of 0.526, 0.515, and 0.930 for plasma, CSF, and plasma and CSF combined models, respectively. Inflammatory biomarkers, including select interleukins, growth factors such as granulocyte colony-stimulating factor, andl-ferritin, had predictive value. <h3>Conclusions and Relevance</h3> This study provides proof-of-concept for a novel multivariable modeling strategy to predict ALS prognosis. These results support unbiased biomarker discovery efforts in larger patient cohorts with detailed longitudinal follow-up.
Expression of the <i>c-myc</i> Proto-oncogene Is Essential for HIV-1 Infection in Activated T Cells
Authors: Yu Sun, Edward A. Clark
Journal: The Journal of Experimental Medicine (1999)

We previously found that activation of primary CD4+ T cells via both the T cell antigen receptor (TCR) and CD28 is required for HIV-1 DNA to be translocated from the cytoplasm to the nucleus. Here we report that expression of c-Myc protein in CD4+ T cells is induced only after such costimulation. In addition, cyclosporin A not only inhibits nuclear import of HIV-1 DNA but also inhibits expression of c-Myc protein. Because of these correlations, we tested whether c-Myc is necessary for nuclear import of HIV-1 DNA. Specific c-myc antisense, but not sense or non-sense, phosphorothioate oligodeoxynucleotides selectively induced the accumulation of two NH2-terminally truncated c-Myc proteins and abolished HIV-1 genome entry into host nuclei. Consequently, both virus replication and HIV-1–induced apoptotic cell death were inhibited. Synthesis of viral full-length DNA was not affected. Specific c-myc antisense oligonucleotide inhibited HIV-1 infection under conditions that did not affect cell cycle entry or proliferation. Thus, c-Myc appears to regulate HIV-1 DNA nuclear import via a mechanism distinct from those controlling entry into the cell cycle.
SOME RELATIONS OF CRIME TO INSANITY AND STATES OF MENTAL ENFEEBLEMENT.
Authors: H. E. ALLISON
Journal: JAMA (1896)

exactly at the operative extremity.I have had sev- eral instruments mounted in this manner, and find that it gives a precision and lightness of touch unat- tainable by any other means.I believe that Dr. Bar- clay's idea constitutes a real progress in otology.Apropos of the effect upon the hearing of nasal and pharyngeal treatment, I urge the importance to the
Klinefelter's syndrome with hypogonadotrophic hypogonadism.
Authors: A G Smals, P W Kloppenberg
Journal: BMJ (1977)

with tritiated thymidine.Thrombosed vessels were occasionally seen in the bases of the oesopha- geal ulcers, with gross epithelial hyperplasia and numerous mitotic figures which were distin- guishable from carcinomas only by the absence of muscular invasion of the disorganised epithelial overgrowth.Most of these lesions cleared with
First cases of spiral enteroscopy in the UK: let's “torque” about it!
Authors: E. Despott, S. Hughes, P. Marden, C. Fraser
Journal: Endoscopy (2010)

We read with interest the paper by Buscaglia et al. entitled “The spiral enteroscopy training initiative: results of a prospective study evaluating the Discovery SB overtube device during small bowel enteroscopy” [1] and subsequent letter and reply from Riccioni et al. [2] and Akerman et al. [3], respectively.
Genomewide Association Studies of Stroke
Authors: M. Arfan Ikram, Sudha Seshadri, Joshua C. Bis, Myriam Fornage, Anita L. DeStefano, Yurii S. Aulchenko, Stephanie Debette, Thomas Lumley, Aaron R. Folsom, Evita G. van den Herik, Michiel J. Bos, Alexa Beiser, Mary Cushman, Lenore J. Launer, Eyal Shahar, Maksim Struchalin, Yangchun Du, Nicole L. Glazer, Wayne D. Rosamond, Fernando Rivadeneira, Margaret Kelly-Hayes, Oscar L. Lopez, Josef Coresh, Albert Hofman, Charles DeCarli, Susan R. Heckbert, Peter J. Koudstaal, Qiong Yang, Nicholas L. Smith, Carlos S. Kase, Kenneth Rice, Talin Haritunians, Gerwin Roks, Paul L.M. de Kort, Kent D. Taylor, Lonneke M. de Lau, Ben A. Oostra, Andre G. Uitterlinden, Jerome I. Rotter, Eric Boerwinkle, Bruce M. Psaty, Thomas H. Mosley, Cornelia M. van Duijn, Monique M.B. Breteler, W.T. Longstreth, Philip A. Wolf
Journal: New England Journal of Medicine (2009)

The genes underlying the risk of stroke in the general population remain undetermined.We carried out an analysis of genomewide association data generated from four large cohorts composing the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, including 19,602 white persons (mean [+/-SD] age, 63+/-8 years) in whom 1544 incident strokes (1164 ischemic strokes) developed over an average follow-up of 11 years. We tested the markers most strongly associated with stroke in a replication cohort of 2430 black persons with 215 incident strokes (191 ischemic strokes), another cohort of 574 black persons with 85 incident strokes (68 ischemic strokes), and 652 Dutch persons with ischemic stroke and 3613 unaffected persons.Two intergenic single-nucleotide polymorphisms on chromosome 12p13 and within 11 kb of the gene NINJ2 were associated with stroke (P<5x10(-8)). NINJ2 encodes an adhesion molecule expressed in glia and shows increased expression after nerve injury. Direct genotyping showed that rs12425791 was associated with an increased risk of total (i.e., all types) and ischemic stroke, with hazard ratios of 1.30 (95% confidence interval [CI], 1.19 to 1.42) and 1.33 (95% CI, 1.21 to 1.47), respectively, yielding population attributable risks of 11% and 12% in the discovery cohorts. Corresponding hazard ratios were 1.35 (95% CI, 1.01 to 1.79; P=0.04) and 1.42 (95% CI, 1.06 to 1.91; P=0.02) in the large cohort of black persons and 1.17 (95% CI, 1.01 to 1.37; P=0.03) and 1.19 (95% CI, 1.01 to 1.41; P=0.04) in the Dutch sample; the results of an underpowered analysis of the smaller black cohort were nonsignificant.A genetic locus on chromosome 12p13 is associated with an increased risk of stroke.
Case 13-1967
Authors: Peter H. Schur, Martin H. Flax
Journal: New England Journal of Medicine (1967)

Presentation of Case First admission. A fourteen-year-old girl was admitted to the hospital because of pain in the joints.She had been well until eight months previously, when a patchy erythematous rash on the hands and pain and swelling of the right knee developed. These symptoms and signs subsided, but six months later the rash on the hands recurred, together with a facial eruption in a butterfly distribution. Two weeks thereafter she entered another hospital because of elevation of the temperature to 104°F. With penicillin and sulfonamide therapy she became afebrile. The rash persisted, and ten days before entry . . .
Glucose turnover and metabolic and hormonal changes in ethanol-induced hypoglycaemia.
Authors: N M Wilson, P M Brown, S M Juul, S A Prestwich, P H Sonksen
Journal: BMJ (1981)

Infusion of 67 g ethanol over four hours in fasted, non-obese normal men (a) induced hypoglycaemia by inhibiting gluconeogenesis; (b) produced noticeable increases in blood lactate, 3-hydroxybutyrate, and free fatty acid concentrations; (c) depressed plasma growth hormone concentrations, despite hypoglycaemia; and (d) raised plasma cortisol concentrations before significant hypoglycaemia occurred. These metabolic changes were explained by the reduction of redox state which accompanies ethanol oxidation. The pronounced changes in metabolic values recorded during this study suggested that the use of parenteral feeding regimens including ethanol needs to be reconsidered.
Receptor activator of nuclear factor (NF)–κB ligand (RANKL) increases vascular permeability: impaired permeability and angiogenesis in eNOS-deficient mice
Authors: Jeong-Ki Min, Young-Lai Cho, Jae-Hoon Choi, Yonghak Kim, Jeong Hun Kim, Young Suk Yu, Jaerang Rho, Naoki Mochizuki, Young-Myeong Kim, Goo Taeg Oh, Young-Guen Kwon
Journal: Blood (2006)
Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine: a randomised controlled trial
Authors: Isabel Leroux-Roels, Astrid Borkowski, Thomas Vanwolleghem, Mamadou Dramé, Frédéric Clement, Eliane Hons, Jeanne-Marie Devaster, Geert Leroux-Roels
Journal: The Lancet (2007)
Choice of Specialty: It's Money That Matters in the USA
Authors: M. H. Ebell
Journal: JAMA (1989)

<h3>To the Editor.—</h3> Recent results from the National Residency Match Program again indicate a relatively poor performance for the primary care fields. Programs in internal medicine and family practice have seen their initial match rates drop significantly in the past 3 years.<sup>1</sup>Discussions with fourth-year medical students about their choice of specialty reveal discouragement with primary care specialties and a trend toward subspecialization. The usual reasons include academic interest, desire for mastery of a subject, or desirefor a better life-style with a shorter workweek.<sup>2</sup> While not mentioned often as a primary motivator for choosing a particular specialty, it seems odd that monetary gain is not a consideration. I examined the competitiveness of the most common specialties and how it correlated with future earning power. Competitiveness for a given specialty was defined as the total number of residency positions filled by graduates of US medical schools on September
Internet based vascular risk factor management for patients with clinically manifest vascular disease: randomised controlled trial
Authors: J. W. P. Vernooij, H. A. H. Kaasjager, Y. van der Graaf, J. Wierdsma, H. M. H. Grandjean, M. M. C. Hovens, G. A. de Wit, F. L. J. Visseren
Journal: BMJ (2012)

<b>Objective</b> To investigate whether an internet based, nurse led vascular risk factor management programme promoting self management on top of usual care is more effective than usual care alone in reducing vascular risk factors in patients with clinically manifest vascular disease. <b>Design</b> Prospective randomised controlled trial. <b>Setting</b> Multicentre trial in secondary and tertiary healthcare setting. <b>Participants</b> 330 patients with a recent clinical manifestation of atherosclerosis in the coronary, cerebral, or peripheral arteries and with at least two treatable risk factors not at goal. <b>Intervention</b> Personalised website with an overview and actual status of patients' risk factors and mail communication via the website with a nurse practitioner for 12 months; the intervention combined self management support, monitoring of disease control, and drug treatment. <b>Main outcome measures</b> The primary endpoint was the relative change in Framingham heart risk score after 1 year. Secondary endpoints were absolute changes in the levels of risk factors and the differences between groups in the change in proportion of patients reaching treatment goals for each risk factor. <b>Results</b> Participants' mean age was 59.9 (SD 8.4) years, and most patients (n=246; 75%) were male. After 1 year, the relative change in Framingham heart risk score of the intervention group compared with the usual care group was −14% (95% confidence interval −25% to −2%). At baseline, the Framingham heart risk score was higher in the intervention group than in the usual care group (16.1 (SD 10.6) <i>v</i> 14.0 (10.5)), so the outcome was adjusted for the separate variables of the Framingham heart risk score and for the baseline Framingham heart risk score. This produced a relative change of −12% (−22% to −3%) in Framingham heart risk score for the intervention group compared with the usual care group adjusted for the separate variables of the score and −8% (−18% to 2%) adjusted for the baseline score. Of the individual risk factors, a difference between groups was observed in low density lipoprotein cholesterol (−0.3, −0.5 to −0.1, mmol/L) and smoking (−7.7%, −14.9% to −0.4%). Some other risk factors tended to improve (body mass index, triglycerides, systolic blood pressure, renal function) or tended to worsen (glucose concentration, albuminuria). <b>Conclusion</b> An internet based, nurse led treatment programme on top of usual care for vascular risk factors had a small effect on lowering vascular risk and on lowering of some vascular risk factors in patients with vascular disease. <b>Trial registration</b> Clinical trials NCT00785031.
824 ANALYSIS OF FACTORS PREDICTING SURVIVAL IN PATIENTS WITH EARLY-STAGE HEPATOCELLULAR CARCINOMA TREATED WITH LASER ABLATION (LA) FOLLOWED BY SELECTIVE CHEMOEMBOLIZATION (STACE)
Authors: C. Telesca, M. Angelico, G. Francica, A. Petrolati, A. Brega, C.M. Pacella
Journal: Journal of Hepatology (2009)
Comparison Of The Effectiveness And Tolerability Of A Combination Of Nasal Antihistamine+Steroid Sprays With Two Over-The-Counter Nasal Sprays Containing Medicinal Products In Patients Suffering From Seasonal Allergic Rhinoconjunctivitis (SAR): LipoNasal Vs. Nasaleze Vs. Levocabastine + Beclometasone
Authors: M.S. Vogtel, L.A. Weston, R. Mösges FAAAAI
Journal: Journal of Allergy and Clinical Immunology (2010)
Abstract LB-162: The onset of <i>MYCN</i> overexpression-induced neuroblastoma is accelerated by <i>ALK</i> mutation in zebrafish
Authors: Jeong-Soo Lee, Shizhen Zhu, Jimann Shin, Antonio R. Perez-Atayde, Hui Feng, Feng Guo, Daniel Helman, Wenchao Wang, Rodney A. Stewart, Rani George, John Kanki, A. Thomas Look
Journal: Cancer Research (2010)

Abstract Neuroblastoma (NB) is the most common extracranial solid tumor in infancy and originates in the peripheral sympathetic nervous system (PSNS). High-risk NB is fatal in the majority of patients, despite intensive myeloablative chemotherapy. The MYCN oncogene is amplified in over 20% of NB, particularly in those with highest risk treatment failure. We have developed a zebrafish NB model by overexpressing human MYCN under the control of the dopamine-beta-hydroxylase (D) promoter specific for noradrenergic cells in the PSNS. Fish from this stable transgenic line developed tumors as early as 4 months of age with approximately 20% penetrance at 8 months of age. The tumors resemble human NB histologically, immunohistochemically, and ultrastructurally. The expression of MYCN suppressed the normal development of PSNS neurons and chromaffin cells in the head kidney during embryogenesis and in young adult fish. In some fish, tumor cells began to repopulate the interrenal gland of the head kidney by 2 months of age. Germline and somatic activating mutations have been identified in the ALK gene, which encodes a receptor tyrosine kinase, in human NB, including those with MYCN amplification. To assess cooperativity between amplified MYCN and mutant ALK genes in transformation, we generated a zebrafish stable transgenic line in which the activated mutant form of ALK (F1174L) was expressed under the control of the DßH promoter. These transgenic animals did not display an abnormal phenotype nor did they develop tumors during the first 6 months of life. In contrast, mutant ALK expression accelerated the onset of MYCN-induced neuroblastoma when the 2 genes were co-expressed in double transgenic fish, indicating that MYCN over-expression and activating ALK mutations can cooperate in tumorigenesis. Although co-expression of mutant ALK accelerated the onset of tumors, it did not rescue the MYCN-induced suppression of PSNS development, suggesting that an as-yet-unidentified tumor suppressor gene, possibly located on distal 1p in the human genome, may be lost to fulfill this role in NB tumorigenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-162.
The Emergence of the Science of Childhood
Authors: Robert L. Martensen
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Review of <i>Feminist Bioethics: At the Center, On the Margins</i>
Authors: Pat Fosarelli
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EVALUATION OF AN ALTERNATIVE METHOD FOR TESTING INTRINSIC UNIFORMITY BY USING A LOW ACTIVITY CO-57 FLOOD SOURCE RATHER THAN A TECHNETIUM-99M POINT SOURCE AT 5 UFOV
Authors: C Child, S Magaris, J Vilani
Journal: Clinical Nuclear Medicine (1995)

The Stale University of New York at Buffalo, Nuclear Medicine Technology Program, HRP, and the Department of Nuclear Medicine, Buffalo, New York.
Interarterial Course of the Right Coronary Artery
Authors: Lars Husmann, Ines Valenta, Patrick Veit-Haibach, Hatem Alkadhi, Thomas Largiader, Philipp A. Kaufmann
Journal: Clinical Nuclear Medicine (2008)

A 50-year-old well-trained cyclist reported increasing brief episodes of chest pain over the last 8 years at maximum exercise during alpine bicycle training. Previous cardiac stress testing on a supine bicycle ergometer revealed nonspecific ST-T abnormalities. In June 2007, the patient was referred for computed tomography coronary angiography, which revealed a coronary anomaly, with the right coronary artery originating from the left coronary sinus and taking an interarterial course between the ascending aorta and the pulmonary trunk. There were no atherosclerotic alterations in the coronary arteries. Subsequent bicycle exercise stress and myocardial perfusion imaging revealed no myocardial perfusion defect.
10 YEAR EXPERIENCE WITH SURGICAL UNROOFING OF ANOMALOUS ORIGIN OF A CORONARY ARTERY FROM THE OPPOSITE SINUS WITH AN INTERARTERIAL COURSE
Authors: Peter C. Frommelt, Stuart Berger, Michele A. Frommelt, Kathy A. Mussatto, James S. Tweddell
Journal: Journal of the American College of Cardiology (2010)
Branch retinal vein occlusion
Authors: V. Chong
Journal: BMJ (2012)

Association with risk factors for arterial disease confirms current theory of pathogenesis 

Retinal vein occlusion is one of the most common causes of sudden painless unilateral loss of vision. It is the second most common retinal vascular disease after diabetic retinopathy.1 Occlusion may occur in the central retinal vein or branch retinal vein. 

Although specific ocular risk factors for central retinal vein occlusion include increased intraocular pressure and anatomical variation of the optic disc, systemic risk factors occur in patients with both types of occlusion.2 3 In a linked case-control study based on data from Danish national registries (doi:10.1136/bmj.e7885), Bertelsen and colleagues investigated comorbidity in patients with branch retinal vein occlusion.4 They were wise to study only patients with branch retinal vein occlusion because patients with central retinal vein occlusion may have ocular risk factors, so combining patients with both types of occlusion in one study of systemic risk factors could bias the findings.

Patients with retinal vein occlusion usually present with sudden loss of vision in …