tbuckley/cabot-search huggingface dataset:
Squamous carcinoma induced by topical idoxuridine therapy?
Authors: Hanna S. Koppang, Eigil Aas
Journal: British Journal of Dermatology (1983)

Journal Article Squamous carcinoma induced by topical idoxuridine therapy? Get access Hanna S. Koppang, Hanna S. Koppang Department of Pathology, Department of Oral Surgery and Oral Medicine, Dental Faculty, University of Oslo, Oslo, Norway Search for other works by this author on: Oxford Academic Google Scholar Eigil Aas Eigil Aas Department of Pathology, Department of Oral Surgery and Oral Medicine, Dental Faculty, University of Oslo, Oslo, Norway Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 108, Issue 4, 1 April 1983, Pages 501–503, https://doi.org/10.1111/j.1365-2133.1983.tb04606.x Published: 01 April 1983
Ronald Michael Vanreenen
Authors: J. B. Stewart
Journal: BMJ (2011)

Ronald Michael Vanreenen (“Mike”) was born in India, where his father was surgeon in the Indian Medical Service. The Vanreenen name could be traced back to the earliest Dutch trekkers and explorers in South Africa. Mike enjoyed three related careers in medicine.

After boarding school at Glenalmond in Perthshire he graduated in medicine from Glasgow University in 1940. Apparently the army did not require his services immediately so he joined the Indian Medical Service like his father. While working as a medical staff captain in Peshawar in 1942 he met and …
Currently Available Versions of Genome-Wide Association Studies Cannot Be Used to Query the Common Haptoglobin Copy Number Variant
Authors: Leah E. Cahill, Majken K. Jensen, Daniel I. Chasman, Aditi Hazra, Andrew P. Levy, Eric B. Rimm
Journal: Journal of the American College of Cardiology (2013)

We recently reported in the Journal that the common biallelic haptoglobin (Hp) copy number variant (CNV) (rs72294371) is predictive of coronary heart disease (CHD) among patients with elevated glycoslylated hemoglobin (HbA1c) [(1)][1]. In 2 independent populations, we observed that participants with
Neutrophilic alveolitis in Sweet's syndrome.
Authors: S J Bourke, A G Quinn, P M Farr, T Ashcroft, G J Gibson
Journal: Thorax (1992)

In a case of Sweet9s syndrome (acute febrile neutrophilic dermatosis) neutrophilic alveolitis was found by lung biopsy. Pulmonary disease in this condition may be underrecognised yet, like the dermatological features, it responds rapidly to corticosteroids.
Disease-Specific Mortality Among Patients With Intraductal Papillary Mucinous Neoplasm of the Pancreas
Authors: Kazumichi Kawakubo, Minoru Tada, Hiroyuki Isayama, Naoki Sasahira, Yousuke Nakai, Naminatsu Takahara, Rie Uchino, Tsuyoshi Hamada, Koji Miyabayashi, Keisuke Yamamoto, Suguru Mizuno, Dai Mohri, Hirofumi Kogure, Takashi Sasaki, Natsuyo Yamamoto, Kenji Hirano, Hideaki Ijichi, Keisuke Tateishi, Kazuhiko Koike
Journal: Clinical Gastroenterology and Hepatology (2013)
More drugs originate outside the industry than it claims
Authors: J. Young
Journal: BMJ (2014)

Many innovative drugs, especially to treat rare diseases, originate not from large drug companies but from small enterprises or academia, a new study has shown.

The research by the European Medicines Agency shows that 44% of innovative drugs recommended for marketing authorisation in the European Union originated from small or medium sized enterprises, academia, public bodies, and public-private partnerships.1

This seems to contradict the claim by Stephen Whitehead, chief executive of the Association of the British Pharmaceutical Industry, that the industry was responsible for developing 90% of the drugs available to patients. …
Managed Care: Success or Failure
Authors: Herbert Renz-Polster
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thioridazine-Associated Ventricular Tachycardia and Isoproterenol
Authors: DANIEL A. PIETRO
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 March 1981Thioridazine-Associated Ventricular Tachycardia and IsoproterenolDANIEL A. PIETRO, M.D.DANIEL A. PIETRO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-3-411_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their recent review of torsades de pointes, Smith and Gallagher (1) recommended overdrive atrial pacing to control this arrhythmia. If qualified personnel are not available, however, to position such a device or if a delay in insertion is expected, an isoproterenol infusion can be lifesaving. We herein report a case of thioridazine-induced QT prolongation with recurrent ventricular tachycardia and fibrillation successfully controlled by isoproterenol.A 53-year-old man with a history of chronic undifferentiated schizophrenia was admitted to the psychiatric service because of psychotic behavior despite therapy with thioridazine, 150 mg twice a day. Except for atypical...References1. SMITHGALLAGHER WJ. "Les torsades de pointes": an unusual ventricular arrhythmia. Ann Intern Med. 1980;93:578-84. LinkGoogle Scholar2. KELLYFAYLAVERTY HJF. Thioridazine hydrochloride (Mellaril): its effect on the electrocardiogram and a report on two fatalities with electrocardiographic abnormalities. Can Med Assoc J. 1963;89:546-54. MedlineGoogle Scholar3. FOWLERMCCALLCHOUHOLMESHANENSON NDTJI. Electrocardiographic changes and cardiac arrhythmias in patients receiving psychotropic drugs. Am J Cardiol. 1976;37:223-30. CrossrefMedlineGoogle Scholar4. KRIKLERCURRY DP. Torsade de pointes, an atypical ventricular tachycardia. Br Heart J. 1976;38:117-20. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DANIEL A. PIETRO, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntipsychoticsAntipsychoticsAntipsychoticsAntipsychotic AgentsTorsade de pointes induced by psychotropic drugs and the prevalence of its risk factorsTorsade de Pointes Due to Noncardiac DrugsInhibition of rat cardiac calcium pump activity by cationic amphiphilic drugsDoes Chlorpromazine Produce Cardiac Arrhythmia Via the Central Nervous System?Cardiac Arrhythmia, Sudden Death, and Psychoactive AgentsArrhythmias in Patients with Drug Toxicity, Electrolyte, and Endocrine DisturbancesCorrection: Authors for Letter on Thioridazine 1 March 1981Volume 94, Issue 3Page: 411-411KeywordsArrhythmiaAtrial fibrillationBehaviorIsoproterenolSchizophreniaVentricular tachycardia ePublished: 1 December 2008 Issue Published: 1 March 1981 PDF downloadLoading ...
Changing Concepts in the Pathogenesis of Experimental Cholera.
Authors: H. Thomas Norris
Journal: Annals of Internal Medicine (1967)

Abstracts1 May 1967Changing Concepts in the Pathogenesis of Experimental Cholera.Author: H. Thomas Norris, M.D. (Associate)Author, Article, & Disclosure InformationPublication: Annals of Internal MedicineVolume 66, Number 5https://doi.org/10.7326/0003-4819-66-5-1047_3 Get AccessSubmit a CommentContributors must reveal any conflict of interest. Comments are moderated. Please see our information for authorsregarding comments on an Annals publication.Name (if multiple authors, separate names by comma)Name field is requiredComment TitleTitle field is requiredAffiliation & Institution (max characters: 200)Affiliations field is requiredCommentComment field is requiredPlease disclose any conflicts of interest or leave the box unchecked if you have noneDisclosure of Any Conflicts of InterestCancelSubmit
PRIVATE TREATMENT OP INSANITY.Read in the Section of Medical Jurisprudence and Neurology, at the Forty-second Annual Meeting of the American Medical Association, held at Washington, D. C., May, 1891.
Authors: N. ROE BRADNER
Journal: JAMA (1892)

Our conclusions are drawn from comparisons. Men rarely either express or entertain any idea that has not been acquired, or suggested, through comparison with more familiar ideas. In the consideration of the subject of this essay, "the private treatment of insanity," we are naturally led—compelled, indeed—to compare this mode with public treatment of the disease, as uniformly practiced in public hospitals and asylums. As it is to be presumed, the tenor of my remarks will be favorable to the private treatment, as compared with public asylum treatment. And I therefore, at the onset, wish to make clearly known my high appreciation of the great good that has been accomplished by and through the means of our great, grand asylums; and that I would by no means be understood to hold that they are either useless or, as a rule, badly managed. On the contrary, I am glad to say, that
Antepartum Dental Radiography and Low Birth Weight
Authors: Robert E. Reiman
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Visipaque (Iodixanol) and Hexabrix (Ioxaglate) in Renal Insufficiency
Authors: Gilbert Deray
Journal: Journal of the American College of Cardiology (2007)

I read with great interest the RECOVER (Renal Toxicity Evaluation and Comparison Between Visipaque and Hexabrix in Patients With Renal Insufficiency Undergoing Coronary Angiography) study by Jo et al. ([1][1]). They compared the renal tolerance of iodixanol and ioxaglate in patients with renal
Bronchial hyperreactivity to distilled water and saline
Authors: S. Anderson
Journal: BMJ (1982)

of staff were able to complete their deliveries and did not subsequently take time off work.No compound fractures were sustained by these persons, although, as suggested by Dr Snook, radiological investigation should be considered following deep limb bites.For those injured, the lower limb was bitten in 70%0 of attacks, the upper limb in 27%, and the trunk in 3%h of attacks.To reduce the number of bitten postal staff, it should be noted that 16 of the 53 upper limb injuries occurred when mail was placed through front- door letter boxes into the expectant jaws beyond.Apparently the tempting sight of intruding digits cannot be resisted.The attacks were otherwise unprovoked.Avoidance may be a learned response: 76% of the staff attacked during these three years were bitten only once.The expression "once bitten, twice shy," therefore has numerical support.
Particulate Matter Air Pollution Stimulates Monocyte Release from the Bone Marrow
Authors: Yukinobu Goto, Hiroshi Ishii, James C. Hogg, Chih-Horng Shih, Kazuhiro Yatera, Renaud Vincent, Stephan F. van Eeden
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

Particulate air pollution (PM10) stimulates alveolar macrophages (AMs) to release immature granulocytes from the bone marrow (BM) into the circulation. This study was designed to determine the effect of PM10 (ambient EHC-93 or inert carbon [CC]) instillation exposure on the monocyte release from the BM and the role of AM in this response. Monocyte precursors were labeled in the BM of rabbits in vivo by an intravenous injection of 5′-bromo-2′-deoxyuridine, and the effects of PM10 were determined by instillation either particles or supernatants of AM exposed to particles into the lungs. Instillation of EHC-93 (500 μg/ml) or supernatants from AM incubated with EHC-93 (100 μg/ml) increased circulating band cell counts (p < 0.05) and shortened the transit time of monocytes through the BM (35.5 ± 2.2 to 25.0 ± 1.5 hours or 36.2 ± 2.6 to 25.7 ± 1.8 hours, p < 0.05) compared with the control subject. CC (1%) instillation also shortened the monocyte BM transit time to 28.4 ± 1.9 hours (p < 0.05), but supernatants of AM incubated with CC did not. We conclude that exposure to atmospheric PM10 stimulates the production of mediators by AM, and these cytokines accelerate the monocyte release from the BM.
A Population-Based Cohort Study of the Effect of Common Mental Disorders on Disability Pension Awards
Authors: Arnstein Mykletun, Simon Overland, Alv A. Dahl, Steinar Krokstad, Ottar Bjerkeset, Nicholas Glozier, Leif E. Aarø, Martin Prince
Journal: American Journal of Psychiatry (2006)

Objective: Mental illness is consistently underrecognized in general health care, which may lead to underestimation of its effects on awards for social security payments. The authors investigated empirically the contribution of psychiatric morbidity to the award of disability pensions, in particular those awarded for physical diagnoses. Method: Using a historical cohort design, the authors utilized a unique link between a large epidemiological cohort study and a comprehensive national database. Baseline information on mental and physical health was gathered from a 1995–1997 population-based health study of those of working age (20–66 years) in Nord-Trøndelag County, Norway, who were not recipients of disability pension (N=45,782). The outcome assessed was the awarding of disability pensions ascribed to specific ICD-10 diagnoses within 6 to 30 months as registered in the National Insurance Administration. Results: Anxiety and depression were robust predictors of disability pension awards in general, even when disability pensions awarded for any mental disorder were excluded. These effects were only partly explained by baseline somatic symptoms and diagnoses and were stronger in individuals aged 20–44 than in those aged 45–66. Somatic symptoms accounted for far more disability pension awards than did somatic diagnoses. Conclusions: The cost of common mental disorders in terms of disability pensions and lost productivity may have been considerably underestimated by official statistics, particularly for younger claimants. The results suggest this might be due both to overuse of physical diagnoses and underrecognition of common mental disorders in primary care.
Abstract 11876: Air Pollution and Myocardial Infarction: A Systematic Review and Meta-Analysis
Authors: Hazrije Mustafic, Patricia Jabre, Christophe Caussin, Mohammad H. Murrad, Sylvie Escolano, Muriel Tafflet, Marie-Cecile Perier, Eloi Marijon, Dewi Vernerey, Jean-Philippe Empana, Xavier Jouven
Journal: Circulation (2011)

Introduction: The association between air pollution and myocardial infarction (MI) remains controversial. Some studies illustrated an increased risk of MI whereas other studies showed no significant effect. The common air-pollutants are ozone (O3), carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), particulate matter within 10 µm (PM10) and particulate matter within 2.5 µm (PM2.5). Hypothesis: We hypothesized that air pollution is associated with an increased risk of MI. Methods: We conducted a systematic review and first meta-analysis searching in several databases to identify studies that evaluated the risk of MI related to air pollution, through March 2011, in any language. Two independent reviewers determined studies eligibility and extracted methodological and outcome data. The relative risks (RRs) were pooled across studies using random-effects model. The I2 statistic and Egger's test were used to respectively assess heterogeneity and publication bias. Results: 33 studies were inclu...
Chickenpox pneumonia: an association with pregnancy.
Authors: T F Esmonde, G Herdman, G Anderson
Journal: Thorax (1990)

Three pregnant patients with chickenpox pneumonia are described. A review of reports published since 1965 together with these cases shows that 28 of the 46 women (61%) were pregnant, and 21 were in the last trimester. Although the disease is more common and more severe in pregnancy, the proportion of deaths was no greater than usual. In this retrospective analysis there was no evidence that treatment with acyclovir conferred benefit but this may have reflected its use only in very ill patients.
Bilateral Bone-Marrow Biopsy
Authors: NORMAN HELMAN
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 July 1975Bilateral Bone-Marrow BiopsyNORMAN HELMAN, M.D.NORMAN HELMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-1-122 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Brunning and associates (Ann Intern Med 82:365-366, 1975) advocate bilateral bone marrow biopsy in staging lymphomas and other neoplasms. To support their contention, they cite the "minimal discomfort" of the procedure and some very impressive percentages derived from their data.I find their conclusion misleading. The Jamshidi needle biopsy is often more than minimally uncomfortable. In all cases, two biopsies are twice as painful as one. To justify the additional procedure, what are the chances that it will give additional information not provided by the first biopsy? Using their data, one can derive the answer of 4.2%...Reference1. JAMSHIDISWAIN KW: Bone marrow biopsy with unaltered architecture: a new biopsy devise. J Lab Clin Med 77:335-342, 1971 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: NORMAN HELMAN, M.D.Affiliations: Department of Internal Medicine Southern California Permanente Medical Group Panorama City, California 91402 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBone Marrow Biopsy for the Staging of Non-Hodgkin's Lymphoma: Bilateral or Unilateral Trephine Biopsy?Assessment of bone marrow histology in Hodgkin's disease: correlation with clinical factorsAssessment of bone marrow histology in Hodgkin's disease: correlation with clinical factorsFrequencies and patterns of bone marrow involvement in non-hodgkin lymphomas: Observations on the value of bilateral biopsies 1 July 1975Volume 83, Issue 1Page: 122-123KeywordsBiopsyBone marrowLymphoma ePublished: 1 December 2008 Issue Published: 1 July 1975 PDF downloadLoading ...
Manic Response to Levodopa Therapy
Authors: Ralph S. Ryback, Robert S. Schwab
Journal: New England Journal of Medicine (1971)

Levodopa (L-dopa) is at present the most effective drug for the treatment of Parkinson's disease1 but psychiatric side effects have been reported in 10 per cent of treated cases. These are confusional hallucinating symptoms, depression, anxiety and euphoric reactions.2 , 3 The pure manic response reported below occurred in a patient whose clinical symptoms of Parkinson's disease were reversed by treatment with L-dopa.Case ReportA 69-year-old retired drawbridge tender with an 8-year history of right-sided Parkinson tremor and rigidity was given small doses of L-dopa, which were gradually increased. There was no improvement until suddenly, when a dosage level of 3 . . .
The human complement system in thrombin-mediated platelet function.
Authors: M J Polley, R Nachman
Journal: The Journal of Experimental Medicine (1978)

Thrombin-mediated platelet membrane-specific uptake of C3 and C5 was demonstrated by radiolabeled components and was visualized electron microscopically utilizing a ferritin marker conjugated to monospecific antibody to each component. The role of complement in thrombin-induced platelet function was determined. Though complement was not essential for thrombin-induced platelet aggregation and release of serotonin, these activities were significantly increased if complement was present. The release of serotonin was found to be a nonlytic process because under the conditions employed, no lactic dehydrogenase was released. The activation of complement was induced by a mechanism which has not been previously described. Thrombin associated with the platelet membrane presumably formed a C3 convertase that entered the known complement sequence at the C3 stage and proceeded to activate the terminal components through the known sequence to C9.
Findings of a national survey of the role of general practitioners in the treatment of opiate misuse: dealing with the opiate misuser.
Authors: A Glanz
Journal: BMJ (1986)

Because there has been a substantial increase in the scale of drug misuse general practitioners have become increasingly concerned in responding to this problem. Little is known, however, about how general practitioners manage drug misusers. The findings from a national survey carried out in mid-1985 of a 5% random sample of general practitioners in England and Wales show the extent to which various actions were undertaken by general practitioners who reported on the consultation with the opiate misuser whom they last attended. In more than half of the cases the opiate misuser had been under the care of the general practitioners for this problem for at least six months. The findings indicate that most general practitioners refer these patients to specialist drug dependence clinics or to general psychiatric services but rarely to other agencies. Opiate drugs had been prescribed in nearly a third of cases. The rate of notification to the Home Office conforms with that in other studies and indicates a high degree of undernotification. More detailed study of general practitioners' activities in managing drug misusers is needed.