Remission of Brain Metastases from Small-Cell Lung Cancer After High-Dose Chemotherapy
Authors: PlETER E. POSTMUS
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 November 1984Remission of Brain Metastases from Small-Cell Lung Cancer After High-Dose ChemotherapyPlETER E. POSTMUS, HANNY HAAXMA-REICHE, LOUK M. VENCKEN, AAFKE F. MEINESZ, DIRK TH. SLEIJFER, NANNO H. MULDERPlETER E. POSTMUSSearch for more papers by this author, HANNY HAAXMA-REICHESearch for more papers by this author, LOUK M. VENCKENSearch for more papers by this author, AAFKE F. MEINESZSearch for more papers by this author, DIRK TH. SLEIJFERSearch for more papers by this author, NANNO H. MULDERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-5-717 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The prognosis of patients with small-cell lung cancer has been improved by combination chemotherapy; however, central nervous system involvement is still an unfavorable prognostic factor (1), probably due to insufficient penetration of cytostatic drugs through the blood-brain barrier. Radiotherapy is at present the only treatment for brain metastases due to small-cell lung cancer. For brain metastases developing or recurring after radiotherapy, no effective therapy is available. In a phase I study (2) of etoposide (VP16-213), therapeutic effects on central nervous system metastases and detectable levels of etoposide in the cerebrospinal fluid were found (3). We report the...References1. BUNNNUGENTMATTHEWS PJM. Central nervous system metastases in small cell bronchogenic carcinoma. Semin Oncol. 1978;5:314-22. MedlineGoogle Scholar2. POSTMUSMULDERSLEIJFERMEINESZVRIESENDORPDE VRIES PNDARE. High dose VP16-213 (etoposide) for refractory malignancies: a phase I study. Cancer Treat Rep. 1984. (In press). MedlineGoogle Scholar3. POSTMUSHOLTHUISHAAXMA-REICHE PJH. Penetration of VP16-213 into cerebrospinal fluid after high-dose intravenous administration. J Clin Oncol. 1984;2:215-20. CrossrefMedlineGoogle Scholar4. NEYSTROMCAPIZZRUDNIK ERS. High dose methotrexate in small cell lung cancer. Cancer. 1983;51:1056-61. CrossrefMedlineGoogle Scholar5. POSTMUSDE VRIESDE VRIES-HOSPERS PEH. Cyclophosphamide and VP16-213 with autologous bone marrow transplantation: a dose escalation study. Eur J Cancer Clin Oncol. 1984;20:777-82. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PlETER E. POSTMUS; HANNY HAAXMA-REICHE; LOUK M. VENCKEN; AAFKE F. MEINESZ; DIRK TH. SLEIJFER; NANNO H. MULDERAffiliations: State University Hospital Groningen, The Netherlands PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBrain metastases from small cell lung cancer: Chemotherapy, radiotherapy, or both?Prospective evaluation of the effect on initial brain metastases from small cell lung cancer of platinum-etoposide based induction chemotherapy followed by an alternating multidrug regimenTreatment of central nervous system metastases from small cell lung cancer with chemotherapyShould cerebral metastases be treated by chemotherapy alone?Chemotherapy for central nervous system metastases from small cell lung cancer. A reviewHigh-dose etoposide for meningeal carcinomatosis in patients with small cell lung cancerAcute neurologic dysfunction after high-dose etoposide therapy for malignant gliomaTeniposide (VM26): An effective treatment for brain metastases of small cell carcinoma of the lungBrain metastases from small cell lung cancer treated with combination chemotherapyPharmacokinetics of high dose etoposide (VP 16–213)High-Dose Chemotherapy for Small Cell Lung Cancer 1 November 1984Volume 101, Issue 5Page: 717-717KeywordsBlood-brain barrierBrainCancer treatmentCentral nervous systemCerebrospinal fluidCombination chemotherapyDrugsHigh-dose chemotherapyLung and intrathoracic tumorsRespiratory system procedures ePublished: 1 December 2008 Issue Published: 1 November 1984 PDF downloadLoading ...