tbuckley/cabot-search huggingface dataset:
Sexual Behavior in Middle Life
Authors: ERIC PFEIFFER, ADRIAAN VERWOERDT, GLENN C. DAVIS
Journal: American Journal of Psychiatry (1972)

Data on sexual behavior were gathered on 261 white men and 241 white women aged 45 to 69. Dramatic differences between men and women of like age were observed in regard to virtually all indicators of sexual behavior, with the men generally reporting greater interest and activity than the women. While there was an overall pattern of declining interest and activity with advancing age, it was also clear that sex still continued to play an important role in the lives of the vast majority of the subjects studied.
Adding colchicine to standard therapy after cardiac surgery reduced risk for the postpericardiotomy syndrome
Authors: Eric R. Bates
Journal: Annals of Internal Medicine (2011)

Source Citation Imazio M, Trinchero R, Brucato A, et al. COlchicine for the Prevention of the Post-pericardiotomy Syndrome (COPPS): a multicentre, randomized, double-blind, placebo-controlled trial. Eur Heart J. 2010;31:2749-54. 20805112
Met and c-Src Cooperate to Compensate for Loss of Epidermal Growth Factor Receptor Kinase Activity in Breast Cancer Cells
Authors: Kelly L. Mueller, Lauren A. Hunter, Stephen P. Ethier, Julie L. Boerner
Journal: Cancer Research (2008)

Abstract Breast cancers are not responsive to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), although 30% of breast cancers overexpress EGFR. The mechanism of intrinsic resistance to EGFR TKIs in breast cancer is the focus of current studies. Here, we observed that EGFR remains tyrosine phosphorylated in breast cancer cells that proliferate in the presence of EGFR TKIs. In one such cell line, SUM229, inhibiting c-Src kinase activity with either a dominant-negative c-Src or a c-Src TKI decreased EGFR phosphorylation on Tyr845, Tyr992, and Tyr1086 in the presence of EGFR TKIs. Conversely, overexpressing wild-type (wt) c-Src in the EGFR TKI–sensitive breast cancer cell line SUM149 increased EGFR kinase–independent EGFR tyrosine phosphorylation. In addition, in the presence of EGFR TKIs, inhibiting c-Src kinase activity decreased cell growth in SUM229 cells, and overexpressing wt-c-Src increased cell growth in SUM149 cells. We identified the receptor tyrosine kinase Met to be responsible for activating c-Src in SUM229 cells. Inhibiting Met kinase activity with a small molecule inhibitor decreased c-Src phosphorylation and kinase activation. In addition, inhibiting Met kinase activity in SUM229 cells decreased EGFR tyrosine phosphorylation and growth in the presence of EGFR TKIs. Stimulating Met kinase activity in SUM149 cells with hepatocyte growth factor increased EGFR tyrosine phosphorylation and cell growth in the presence of EGFR TKIs. These data suggest a Met/c-Src–mediated signaling pathway as a mediator of EGFR tyrosine phosphorylation and cell growth in the presence of EGFR TKIs. [Cancer Res 2008;68(9):3314–22]
Sexual Disorders in Women
Authors: P. R. Boucher
Journal: BMJ (1952)

Activity-dependent competition shapes corticospinal (CS) axon outgrowth in the spinal cord during development. An important question in neural repair is whether activity can be used to promote outgrowth of CS axons in maturity. After injury, spared CS axons sprout and make new connections, but often not enough to restore function. We propose that electrically stimulating spared axons after injury will enhance sprouting and strengthen connections with spinal motor circuits. To study the effects of activity, we electrically stimulated CS tract axons in the medullary pyramid. To study the effects of injury, one pyramid was lesioned. We studied sparse ipsilateral CS projections of the intact pyramid as a model of the sparse connections preserved after CNS injury. We determined the capacity of CS axons to activate ipsilateral spinal motor circuits and traced their spinal projections. To understand the separate and combined contributions of injury and activity, we examined animals receiving stimulation only, injury only, and injury plus stimulation. Both stimulation and injury alone strengthened CS connectivity and increased outgrowth into the ipsilateral gray matter. Stimulation of spared axons after injury promoted outgrowth that reflected the sum of effects attributable to activity and injury alone. CS terminations were densest within the ventral motor territories of the cord, and connections in these animals were significantly stronger than after injury alone, indicating that activity augments injury-induced plasticity. We demonstrate that activity promotes plasticity in the mature CS system and that the interplay between activity and injury preferentially promotes connections with ventral spinal motor circuits.
Trichilemmomas in Cowden's Disease
Authors: Amir H. Mehregan
Journal: JAMA (1977)

To the Editor.—  Papules of the face and oral mucous membranes are the most characteristic lesions in Cowden's disease. Other changes include goiter, thyroid adenoma and carcinoma, hypothyroidism, hypertension, leiomyomas of the uterus, punctate keratoses of the palms, and vitiligo. Affected women have almost invariably had fibrocystic disease, carcinoma of the breast, or both. At least one previously reported patient who had fibrocystic disease1is now known to have died of metastatic carcinoma of the breast. Histopathologic examination of the cutaneous growths has been said to show only nonspecific changes.1-4  We have studied numerous biopsy specimens from several patients with Cowden's disease and have identified the cutaneous facial tumors as trichilemmomas, a benign neoplasm of the lower outer root sheath consisting of poorly keratinized, glycogen-rich cells surrounded by a vitreous membrane.5-7In a report of 40 trichilemmomas,5no instance of multiple tumors was uncovered except in
Overview on practices in thalassemia intermedia management aiming for lowering complication rates across a region of endemicity: the OPTIMAL CARE study
Authors: Ali T. Taher, Khaled M. Musallam, Mehran Karimi, Amal El-Beshlawy, Khawla Belhoul, Shahina Daar, Mohamed-SalahEldin Saned, Abdul-Hamid El-Chafic, Maria R. Fasulo, Maria D. Cappellini
Journal: Blood (2009)
Combined Therapy for Chloroquine-Resistant Plasmodium falciparum Infection
Authors: Peter J. Bartelloni
Journal: JAMA (1967)

Combined therapy with a single dose of the long-acting sulfonamides, sulphormethoxine, and pyrimethamine was found to be effective alone and in combination with quinine sulfate for treatment of<i>Plasmodium falciparum</i>infections in nonimmune patients. While combined chloroquine-quinine therapy was usually effective in control of clinical disease, 41% of the patients had recrudescences shortly after therapy was completed (14.3 days). In contrast, only 2% of the patients treated with sulphormethoxine, pyrimethamine, and quinine had a reappearance of clinical disease. Five nonimmune patients had a clinical cure of their primary infection following a single dose of the sulphormethoxine-pyrimethamine combination.
Review: Rosiglitazone increases risk for cardiovascular outcomes and mortality compared with pioglitazone in type 2 diabetes
Authors: Prakash Deedwania
Journal: Annals of Internal Medicine (2011)

ACP Journal Club16 August 2011Review: Rosiglitazone increases risk for cardiovascular outcomes and mortality compared with pioglitazone in type 2 diabetesPrakash Deedwania, MDPrakash Deedwania, MDUniversity of California, San Francisco, School of Medicine, Fresno, California, USA (P.D.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-4-201108160-02012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationLoke YK, Kwok CS, Singh S. Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies. BMJ. 2011;342:d1309. https://pubmed.ncbi.nlm.nih.gov/21415101Clinical Impact RatingsGIM/FP/GP: Cardiology: Endocrinology: References1 Mazzone T, Meyer PM, Feinstein SB, et al. Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: a randomized trial. JAMA. 2006;296:2572-81. [PMID: 17101640] Google Scholar2 Nissen SE, Nicholls SI, Wolski K, et al; PERISCOPE Investigators. Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trial. JAMA 2008;299:1561-73. [PMID: 18378631] Google Scholar3 Montori VM, Shah ND. What have we learnt from the rosiglitazone saga? [Editorial] BMJ. 2011;342:d1354. [PMID: 21415102] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of California, San Francisco, School of Medicine, Fresno, California, USA (P.D.)This article was published at Annals.org on 2 August 2011. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 August 2011Volume 155, Issue 4Page: JC2-12KeywordsCohort studiesHeart failureLongitudinal studiesMyocardial infarctionObservational studiesRetrospective studiesSystematic reviewsType 2 diabetes ePublished: 16 August 2011 Issue Published: 16 August 2011 CopyrightCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Partial Pericardial Defect
Authors: Kean-Wah Lau, Zee-Pin Ding
Journal: Circulation (1998)

A 49-year-old healthy-looking man presented with vague chest discomfort in September 1995.Physical examination was unremarkable.Echocardiography revealed mild mitral valve prolapse and an incomplete pericardial echo, arousing suspicion of a partial pericardial defect.A subsequent CT scan of the thorax clearly demonstrated the incomplete pericardial defect, the rim of which was heavily calcified and constricted the partially herniated right and left ventricles (Fig 1).Except for a mild focal compression at the junction of the middle and distal third of the left anterior descending coronary artery, there was no significant coronary artery abnormality on contrast angiography.On hemodynamic evaluation, no gradient was detected across the ventricular constriction.The CT findings were confirmed during surgical pericardiotomy (Fig 2).Since surgery, the patient has remained physically well and asymptomatic.
Textbook of Virology for Students and Practitioners of Medicine.
Authors: A. J. Rhodes, C. E. Van Rooyen
Journal: JAMA (1953)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Calculation of pH with the Use of Venous Blood
Authors: Robert B. Ullian, Isabel Glazer Kogos, Murray Golub, Myron Stein
Journal: New England Journal of Medicine (1961)

KNOWLEDGE of the peripheral venous carbon dioxide content or "carbon dioxide combining power" as ordinarily determined in most hospital chemistry laboratories is inadequate to evaluate problems in acid–base balance. To ascertain the exact nature of an abnormality in acid–base balance, and to distinguish the respiratory from the metabolic adjustments, it is necessary to measure two of the following three variables: the arterial-blood pH, requiring arterial puncture with anaerobic technics and immediate measurement either with colorimetric methods1 or with expensive apparatus; the arterial or venous-plasma carbon dioxide (CO2) content measured with the Van Slyke and Neill2 or similar apparatus; . . .
TELANGIECTASIA MACULARIS ERUPTIVA PERSTANS
Authors: F. PARKES WEBER, R. HELLENSCHMIED
Journal: British Journal of Dermatology (1930)

British Journal of DermatologyVolume 42, Issue 8-9 p. 374-382 TELANGIECTASIA MACULARIS ERUPTIVA PERSTANS F. PARKES WEBER M.D., F.R.C.P., F. PARKES WEBER M.D., F.R.C.P. Senior Physician, German Hospital, LondonSearch for more papers by this authorR. HELLENSCHMIED M.D., R. HELLENSCHMIED M.D. House Physician, German Hospital, London.Search for more papers by this author F. PARKES WEBER M.D., F.R.C.P., F. PARKES WEBER M.D., F.R.C.P. Senior Physician, German Hospital, LondonSearch for more papers by this authorR. HELLENSCHMIED M.D., R. HELLENSCHMIED M.D. House Physician, German Hospital, London.Search for more papers by this author First published: August 1930 https://doi.org/10.1111/j.1365-2133.1930.tb09430.xCitations: 33AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume42, Issue8-9August 1930Pages 374-382 RelatedInformation
Creation and Retention of the Next Generation of Physician-Scientists for Child Health Research
Authors: David N Cornfield, Robert Lane, Steven H Abman
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib
Authors: Carlo Spirli, Carola M. Morell, Luigi Locatelli, Stefano Okolicsanyi, Cecilia Ferrero, Amy K. Kim, Luca Fabris, Romina Fiorotto, Mario Strazzabosco
Journal: Hepatology (2012)

Mutations in polycystins are a cause of polycystic liver disease. In polycystin-2 (PC2)-defective mice, cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)-dependent activation of the Rat Sarcoma (Ras)/rapidly accelerated fibrosarcoma (Raf)/mitogen signal-regulated kinase-extracellular signal-regulated kinase (ERK) 1/2 pathway stimulates the growth of liver cysts. To test the hypothesis that sorafenib, a Raf inhibitor used for the treatment of liver and kidney cancers, inhibits liver cyst growth in PC2-defective mice, we treated PC2 (i.e., Pkd2(flox/-) :pCxCreER(TM) [Pkd2cKO]) mice with sorafenib-tosylate for 8 weeks (20-60 mg/kg/day). Sorafenib caused an unexpected increase in liver cyst area, cell proliferation (Ki67), and expression of phosphorylated ERK (pERK) compared with Pkd2cKO mice treated with vehicle. When given to epithelial cells isolated from liver cysts of Pkd2cKO mice (Pkd2cKO-cells), sorafenib progressively stimulated pERK1/2 and cell proliferation [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium and bromodeoxyuridine assay (MTS)] at doses between 0.001 and 1 μM; however, both pERK1/2 and cell proliferation significantly decreased at the dose of 10 μM. Raf kinase activity assay showed that whereas B-Raf is inhibited by sorafenib in both wild-type (WT) and Pkd2cKO cells, Raf-1 is inhibited in WT cells but is significantly stimulated in Pkd2cKO cells. In Pkd2cKO cells pretreated with the PKA inhibitor 14-22 amide, myristolated (1 μM) and in mice treated with octreotide in combination with sorafenib, the paradoxical activation of Raf/ERK1/2 was abolished, and cyst growth was inhibited.
Doctors, Dilemmas, Decisions
Authors: V. Smith
Journal: BMJ (1995)

Ben Essex BMJ Publishing Group, pounds sterling22.95, pp 301 ISBN 0 7279 0859 6

From time to time most of us feel the urge to keep a casebook. A typical general practitioner does at least 5000 consultations a year. What a treasure trove for a thoughtful author. Pickles, Balint, Byrne and Long, Huygen—all these figures from the general practice pantheon, and many more, based their work on the collection of ordinary cases. And, of course, the intelligent analysis of them.

Ben Essex, too, has kept a casebook, from which he has distilled over 800 “rules” of good practice. (He reassures us …
Biopolymer/Calcium Phosphate Scaffolds for Bone Tissue Engineering
Authors: Jianhua Li, Bryan. A. Baker, Xiaoning Mou, Na Ren, Jichuan Qiu, Robert I. Boughton, Hong Liu
Journal: Advanced Healthcare Materials (2013)

With nearly 30 years of progress, tissue engineering has shown promise in developing solutions for tissue repair and regeneration. Scaffolds, together with cells and growth factors, are key components of this development. Recently, an increasing number of studies have reported on the design and fabrication of scaffolding materials. In particular, inspired by the nature of bone, polymer/ceramic composite scaffolds have been studied extensively. The purpose of this paper is to review the recent progress of the naturally derived biopolymers and the methods applied to generate biomimetic biopolymer/calcium phosphate composites as well as their biomedical applications in bone tissue engineering.
Accumulation of dysfunctional effector CD8+T cells in the liver of patients with chronic HCV infection
Authors: Carla Nisii, Massimo Tempestilli, Chiara Agrati, Fabrizio Poccia, Guido Tocci, Maria Antonella Longo, Gianpiero D'Offizi, Roberto Tersigni, Oreste Lo Iacono, Giorgio Antonucci, Alessandra Oliva
Journal: Journal of Hepatology (2005)
Association of Chronic Obstructive Pulmonary Disease Severity and <i>Pneumocystis</i> Colonization
Authors: Alison Morris, Frank C. Sciurba, Irina P. Lebedeva, Andrew Githaiga, W. Mark Elliott, James C. Hogg, Laurence Huang, Karen A. Norris
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

Factors modulating the variable progression of chronic obstructive pulmonary disease (COPD) are largely unknown, but infectious agents may play a role. Because Pneumocystis has previously been shown to induce a CD8(+) lymphocyte- and neutrophil-predominant response similar to that in COPD, we explored the association of the organism with accelerated disease progression. We examined Pneumocystis colonization rates in lung tissue obtained during lung resection or transplantation in smokers with a range of airway obstruction severity and in a control group with lung diseases other than COPD. Using nested polymerase chain reaction, Pneumocystis colonization was detected in 36.7% of patients with very severe COPD (Global Health Initiative on Obstructive Lung Disease [GOLD] Stage IV) compared with 5.3% of smokers with normal lung function or less severe COPD (Stages 0, I, II, and III) (p = 0.004) and with 9.1% of control subjects (p = 0.007). Colonized subjects exhibited more severe airway obstruction (median FEV(1) = 21% predicted versus 62% in noncolonized subjects, p = 0.006). GOLD IV was the strongest predictor of Pneumocystis colonization (odds ratio = 7.3, 95% confidence interval = 2.4-22.4, p < 0.001) and was independent of smoking history. We conclude that there is a strong association between Pneumocystis colonization and severity of airflow obstruction in smokers, suggesting a possible pathogenic link with COPD progression.
Abstract 3327: N-terminal domain of Tyrosyl-DNA phosphodiesterase I (Tdp1) is critical for its cellular function.
Authors: Selma M. Cuya, Keith C. Wanzeck, Evan Q. Comeaux, Robert C. van Waardenburg
Journal: Cancer Research (2013)

Abstract Tyrosyl-DNA phosphodiesterase I (Tdp1) is a highly conserved eukaryotic DNA repair enzyme that catalyzes the resolution of 3’ and 5’ phospho-DNA adducts. Tdp1 has been implicated in the repair of DNA topoisomerase I (Top1)-DNA covalent complexes reversibly stabilized by camptothecins (CPTs) such as the FDA approved CPT derivatives topotecan and irinotecan. Tdp1 contains two HKD-motifs that provide two catalytic histidines that function as a nucleophile and an acid-base residue. A mutation of the acid-base His to Arg (H493R) in human Tdp1 is associated with the rare recessive ataxia SCAN1. hTdp1H493R and the analogous yeast mutant (Tdp1H432R) enhances cell sensitivity to CPT. In addition, the toxicity induced by this mutant is caused by the formation of a more stable Tdp1-DNA covalent intermediate, a rare characteristic for a DNA repair enzyme. However, this His to Arg substitution induces a minor toxic phenotype compared to other substitutions, such as the His432 to Asn substitution, which induces a Top1 dependent cellular lethality. A band depletion assay suggests that in vivo/cell Tdp1His432Asn remains in complex with Top1 on the DNA, which was not observed in a biochemical in vitro assay. Biochemical studies revealed that Tdp1 catalysis is independent of the N-terminal domain. Among Tdp1 proteins, the N-terminal domain is poorly conserved in sequence and size (∼80aa for yeast and 140aa for human Tdp1). We investigated the role of the N-terminal domain for Tdp1 activity in the cell. The N-terminal truncated proteins showed similar cellular distribution as the full-length proteins. Interestingly, the N-terminal truncated proteins did not display the toxicity that was observed with the full-length Tdp1 mutant proteins. This suggests that the N-terminal domain is a critical determinate of Tdp1 cellular function. Preliminary results from our human cell line model shows similar results implying that the function of the N-terminal domain is conserved among Tdp1 proteins although it is poorly conserved. Further studies are necessary to ensure that these constructs are properly distributed. Moreover, the N-terminal domain of hTdp1 is post-translational modified, while our preliminary results suggest that this domain is important for protein-protein interaction and Tdp1 recruitment to its substrates. Understanding Tdp1 substrate and protein-interactions are important in the development of Tdp1 as therapeutic target. This work is in part supported by the ADDA. Citation Format: Selma M. Cuya, Keith C. Wanzeck, Evan Q. Comeaux, Robert C. van Waardenburg. N-terminal domain of Tyrosyl-DNA phosphodiesterase I (Tdp1) is critical for its cellular function. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3327. doi:10.1158/1538-7445.AM2013-3327