tbuckley/cabot-search huggingface dataset:
Treatment of Uremic Pericarditis
Authors: Anthony J. Vaz
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The results of the use of local steroid instillation in intractable uremic pericarditis in 45 patients described by Buselmeier et al (240:1358, 1978) were impressive. We would like to submit the following modification for the placement of the catheter in the pericardial space. After sterile preparation of the sternum, the area below the xiphisternum is infiltrated with procaine hydrochloride. Blunt dissection is performed to expose the pericardium. This is easily accomplished, as the pericardium is superficial in this position. Then, under direct vision, a catheter is placed and positioned so that adequate fluid is easily aspirated. The steroid is then instilled in the manner suggested by Buselmeier et al. This approach has the following advantages: (1) Blind needle insertion is avoided. (2) The catheter could be placed in excellent position. (3) Chances of a traumatic hemorrhagic effusion are diminished. (4) Loculated and adhesive compartment formation is
Rheumatoid Arthritis Associated with Expanded Populations of Granular Lymphocytes
Authors: JAMES C. BARTON
Journal: Annals of Internal Medicine (1986)

Two patients with classic rheumatoid arthritis developed severe neutropenia and increased numbers of large granular lymphocytes in the blood and bone marrow. These lymphocytes exhibited homogeneous surface membrane immunophenotypes of Leu5+, Leu 11-, Leu4 + , Leu3-, Leu2-, Leu7+ and Leu5+ , Leu11+, Leu4+ , Leu3-, Leu2+ , Leu7-, respectively. In both patients, neutropenia was initially corrected with corticosteroid therapy; long-term improvement followed low-dose oral cyclophosphamide and methotrexate therapies. In these 2 patients and 12 previous patients with rheumatoid arthritis associated with expanded populations of immunophenotypically homogeneous large granular lymphocytes, neutropenia occurred in all 14, thrombocytopenia in 6, anemia in 7, and mild or moderate splenomegaly in 12. In contrast to Felty's syndrome, granular lymphocyte expansions in rheumatoid arthritis usually occur in older patients, may appear simultaneously with arthritis, and are usually associated with normal or elevated blood leukocyte counts. Mild hemocytopenias in these patients can often be managed with observation. Therapy with corticosteroids or immunosuppressive-cytotoxic drugs may be beneficial in more severe cases, but splenectomy is not recommended.
Deaths from chronic disease fall in Australia but concerns rise for the future
Authors: M. Sweet
Journal: BMJ (2011)

Premature deaths due to chronic diseases fell significantly in Australia between 1997 and 2007, and reductions in smoking rates are being given part of the credit.

According to a new report, mortality from chronic conditions fell by 41%, from 417 deaths per 100 000 people in 1997 to 297 deaths per 100 000 people in 2007.

Over the same time, premature mortality—deaths occurring before 75 years of age—fell by 63%, from 153 to 94 deaths per 100 000 people.

“In 2007, a person was 17% less likely to die prematurely from a chronic disease than in 1997,” says an Australian Institute of Health and Welfare report, Key indicators of progress for chronic disease and associated determinants . 

It covers 42 indicators, with the aim of establishing a baseline for future report cards on progress against chronic …
UK public must expect to pay for long term care, says care services minister
Authors: A. Gulland
Journal: BMJ (2011)

<h3>Abstract</h3> The Fair Proportion of a species in a phylogenetic tree is a very simple measure that has been used to assess its value relative to the overall phylogenetic diversity represented by the tree. It has recently been proved by Fuchs and Jin to be equal to the Shapley Value of the coallitional game that sends each subset of species to its rooted Phylogenetic Diversity in the tree. We prove in this paper that this result extends to the natural translations of the Fair Proportion and the rooted Phylogenetic Diversity to rooted phylogenetic networks. We also generalize to rooted phylogenetic networks the expression for the Shapley Value of the unrooted Phylogenetic Diversity game on a phylogenetic tree established by Haake, Kashiwada and Su.
Identification of an Agent Selectively Targeting DPC4 (Deleted in Pancreatic Cancer Locus 4)–Deficient Pancreatic Cancer Cells
Authors: Hong Wang, Haiyong Han, Daniel D. Von Hoff
Journal: Cancer Research (2006)

Abstract One of the most common types of genetic alterations in cancer is the loss-of-function mutations in tumor-suppressor genes. Such mutations are usually very specific to cancer cells and present attractive and unique opportunities for therapeutic interventions. However, for various reasons, antitumor agents that target loss-of-function mutations have not been readily identified. In this report, using the deleted in pancreatic cancer locus 4 (DPC4) gene in pancreatic cancer as an example, we show the feasibility of a novel screening strategy, which we have named Pharmacological Synthetic Lethal Screening, for the identification of agents that selectively target cancer cells with loss-of-function mutations. We created DPC4 isogenic cell lines through the restoration of wild-type DPC4 in a pancreatic cancer cell line, BxPC-3, whose DPC4 gene was homozygously deleted. The isogenic cell lines were then used in the Pharmacological Synthetic Lethal Screening to evaluate compound libraries for antiproliferative activity and selectivity against DPC4 deficiency. After screening 19,590 compounds, we identified one lead compound, UA62001, which showed 4.6-fold selectivity against DPC4 deficiency in the DPC4 isogenic cell lines. UA62001 selectivity was also seen in another set of DPC4 isogenic cell lines generated by small interfering RNA knockdown. In addition, UA62001 was evaluated in commonly used pancreatic cancer cell lines. A fairly good correlation between DPC4 deficiency and UA62001 sensitivity was observed. Cell cycle analysis indicates that UA62001 arrests cells in S and G2-M phases. The results of microarray gene expression profiling and quantitative real-time reverse transcription-PCR suggest that cyclin B/CDC2 and minichromosome maintenance complexes might be the downstream cellular targets of UA62001. (Cancer Res 2006; 66(19): 9722-30)
Treatment of Primary Dysthymia With Group Cognitive Therapy and Pharmacotherapy: Clinical Symptoms and Functional Impairments
Authors: Arun V. Ravindran, Hymie Anisman, Zul Merali, Yoland Charbonneau, John Telner, Robert J. Bialik, Andrew Wiens, Jack Ellis, Jenna Griffiths
Journal: American Journal of Psychiatry (1999)

This study assessed the efficacy of antidepressant treatment (sertraline) and group cognitive behavior therapy, alone or in combination, in primary dysthymia. The clinical features of dysthymia, as well as the functional impairments associated with the illness (e.g., quality of life, stress perception, coping styles), were evaluated.Patients (N = 97) diagnosed with primary dysthymia, but no other current comorbid disorder, received either sertraline or placebo in a double-blind design over 12 weeks. In addition, a subgroup of the patients (N = 49) received a structured, weekly group cognitive behavior therapy intervention.Treatment with sertraline, with or without group cognitive behavior therapy, reduced the functional impairment of depression. The reductions were similar in the drug-cognitive therapy group and in subjects who received the drug alone. Furthermore, while group cognitive behavior therapy alone reduced the depression scores, this effect was not significantly greater than the effect of the placebo. The drug treatment also induced pronounced improvement in the functional measures, and in some respects these effects were augmented by group cognitive behavior therapy. Among patients who responded favorably to cognitive behavior therapy, the improvements in the functional measures were similar to those who responded to drug treatment, whereas such functional changes were not seen among patients who responded to placebo.Sertraline treatment effectively reduces the clinical symptoms and functional impairments associated with dysthymia. Although the group cognitive behavior therapy intervention was less effective in alleviating clinical symptoms, it augmented the effects of sertraline with respect to some functional changes, and in a subgroup of patients it attenuated the functional impairments characteristic of dysthymia.
Vaccine targeting HIF1A in triple negative breast cancer
Authors: Denise Cecil, Daniel Herendeen, Meredith Slota, Yushe Dang, Megan O'Meara, Ekram Gad, Lauren Rastetter, Marlese Koehnlein, Mary L Disis
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts The high rates of relapse in triple negative breast cancer (TNBC) are thought to be due to the presence of increased levels of cancer stem cells (CSC), which have been shown to be resistant to standard therapies. It has been demonstrated that hypoxia-inducible factor 1 (HIF1A) can
Mucosal lichen sclerosus/lichen planus overlap syndromes
Authors: P. MARREN, P. MILLARD, Y. CHIA, F. WOJNAROWSKA
Journal: British Journal of Dermatology (1994)

Summary Lichen sclerosus and lichen planus affecting cutaneous sites are easily distinguishable clinically. Clinical signs on mucosal sites, however, may not allow differentiation between these diseases, and reliance is frequently placed on histopathological findings. We report a series of seven patients with clinical evidence of coexisting vulval lichen sclerosus and lichenoid oral lesions. All patients had vulval biopsies, and four had oral biopsies. Histology of all the vulval biopsy specimens showed features consistent with lichen sclerosus. Two of these patients developed vulval intraepithelial neoplasia during the course of their disease, and one progressed to a well-differentiated squamous carcinoma. Histology of the oral lesions showed features that were predominantly those of lichen planus. There are, however, few reports of histologically proven oral lichen sclerosus. Variations in histopathological descriptions of lichen sclerosus, depending on duration of disease, have been reported, particularly with regard to the position of the inflammatory infiltrate in relation to the dermo-epidermal junction. We believe that these patients may have oral lichen sclerosus, or at the very least make up a distinctive group who need to be identified and followed up, as their risk of oral dysplasia is unknown.
On staying calm
Authors: C. Douglas
Journal: BMJ (1998)

“The worst is when you're trying to get a surgical history and they keep talking about something else.”

“Or they tell you something and the registrar comes along and gets a completely different story. That's really awful.”

In a tutorial group we are discussing confusion in the elderly. It is something the students seem to have encountered often; they are relieved to talk about it. The first girl continues: “My surgical man was in with his prostate but all he could talk about was his wife.”

“His wife?” “She'd just died.” “Oh.” “Not a surgical problem,” says the …
Nonsense Mutations in hERG Cause a Decrease in Mutant mRNA Transcripts by Nonsense-Mediated mRNA Decay in Human Long-QT Syndrome
Authors: Qiuming Gong, Li Zhang, G. Michael Vincent, Benjamin D. Horne, Zhengfeng Zhou
Journal: Circulation (2007)

Long-QT syndrome type 2 (LQT2) is caused by mutations in the human ether-a-go-go-related gene (hERG). More than 30% of the LQT2 mutations result in premature termination codons. Degradation of premature termination codon-containing mRNA transcripts by nonsense-mediated mRNA decay is increasingly recognized as a mechanism for reducing mRNA levels in a variety of human diseases. However, the role of nonsense-mediated mRNA decay in LQT2 mutations has not been explored.We examined the expression of hERG mRNA in lymphocytes from patients carrying the R1014X mutation using a technique of allele-specific transcript quantification. The R1014X mutation led to a reduced level of mutant mRNA compared with that of the wild-type allele. The decrease in mutant mRNA also was observed in the LQT2 nonsense mutations W1001X and R1014X using hERG minigenes expressed in HEK293 cells or neonatal rat ventricular myocytes. Treatment with the protein synthesis inhibitor cycloheximide or RNA interference-mediated knockdown of the Upf1 protein resulted in the restoration of mutant mRNA to levels comparable to that of the wild-type minigene, suggesting that hERG nonsense mutations are subject to nonsense-mediated mRNA decay.These results indicate that LQT2 nonsense mutations cause a decrease in mutant mRNA levels by nonsense-mediated mRNA decay rather than production of truncated proteins. Our findings suggest that the degradation of hERG mutant mRNA by nonsense-mediated mRNA decay is an important mechanism in LQT2 patients with nonsense or frameshift mutations.
Improved survival of patients with multiple myeloma after the introduction of novel agents and the applicability of the International Staging System (ISS): an analysis of the Greek Myeloma Study Group (GMSG)
Authors: E Kastritis, K Zervas, A Symeonidis, E Terpos, S Delimbassi, N Anagnostopoulos, E Michali, A Zomas, E Katodritou, D Gika, A Pouli, D Christoulas, M Roussou, Z Kartasis, T Economopoulos, M A Dimopoulos
Journal: Leukemia (2009)
Hyperguanidemia and Hypoglycemic Unresponsiveness in Renal Disease.
Authors: B. D. Cohen
Journal: Annals of Internal Medicine (1961)

s1 May 1961Hyperguanidemia and Hypoglycemic Unresponsiveness in Renal Disease.B. D. Cohen, M.D., N. Spritz, M.D., A. L. Rubin, M.D., E. H. Luckey, M.D., F.A.C.P.B. D. Cohen, M.D.Search for more papers by this author, N. Spritz, M.D.Search for more papers by this author, A. L. Rubin, M.D.Search for more papers by this author, E. H. Luckey, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1062_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBecause of the occurrence of hypoglycemia in uremic patients during insulin and glucose treatment for hyperpotassemia a group of 20 patients with renal disease was studied with the standard insulin tolerance test. These were compared to 19 comparably ill patients free of renal disease. Although the initial hypoglycemia was identical a significantly delayed blood sugar was noted in the kidney disease group. These groups were re-examined using epinephrine and glucagon followed by periodic blood sugar determinations. The response to both tests showed a diminished glycolysis in the group with renal disease suggesting a deficiency in liver glycogen storage. In addition,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPer-Attack Reporting of Prodromal Symptoms Concurrent with C1-Inhibitor Treatment of Hereditary Angioedema AttacksCarbohydrate metabolism and uraemia ? Mechanisms for glycogenolysis and gluconeogenesisPathobiochemie und Pathophysiologie der chronischen NiereninsuffizienzMetabolic Abnormalities in UremiaHyperglycemia and Hyperosmolality Complicating Peritoneal DialysisJAMES BOYER, M.D., GORDON N. GILL, M.D., FRANKLIN H. EPSTEIN, M.D.Etude de la glycor�gulation dans l'insuffisance r�nale chronique 1Abnormal carbohydrate metabolism in renal failureThe Carbohydrate Intolerance of Uremic PatientsFRED B. WESTERVELT JR., M.D., GEORGE E. SCHREINER, M.D., F.A.C.P. 1 May 1961Volume 54, Issue 5Page: 1062-1062KeywordsBlood sugarEpinephrineGlucagonGlucoseGlycogensHypoglycemiaHypoglycemicsInsulinLiverRenal diseases ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...
Similar prediction of mortality by the health assessment questionnaire in patients with rheumatoid arthritis and the general population
Authors: T Sokka
Journal: Annals of the Rheumatic Diseases (2004)

<b>Background:</b> The self report health assessment questionnaire (HAQ) quantifies disability in activities of daily living (ADL). In patients with rheumatoid arthritis, the HAQ predicts mortality, work disability, and hip replacement surgery. It has been widely used in rheumatology, but population based data are rare. <b>Objective:</b> To determine whether the HAQ predicts mortality in patients with rheumatoid arthritis (n = 1095) and community controls (n = 1490). <b>Methods:</b> A mailed questionnaire including the HAQ, visual analogue scales for pain and global health, comorbidities, education level, height, weight, and smoking status was administered in June 2000. Two years later, the vital status of the subjects was ascertained from the Finnish Population Register database. <b>Results:</b> There were 41 deaths (10.1%) among the 404 patients with rheumatoid arthritis who had a baseline HAQ ⩾1 (indicating at least some difficulty in most ADL), and 16 (2.3%) among 691 patients with HAQ &lt;1 (p&lt;0.001); in the community controls the values were 20 (13.6%) among 147 with HAQ ⩾1, and 14 (1.0%) among 1343 with HAQ &lt;1 (p&lt;0.001). A higher HAQ score was an independent predictor of mortality in patients with rheumatoid arthritis (hazard ratio 2.73 (95% confidence interval, 1.86 to 4.02); p&lt;0.001) and in community controls (2.75 (1.61 to 4.70); p&lt;0.001). <b>Conclusions:</b> The HAQ predicts mortality in the community population as well as in patients with rheumatoid arthritis. People with similar levels of disability appear to have a similar likelihood of mortality over two years.
Psychiatrist-Patient Boundary Issues Following Treatment Termination
Authors: Carl P. Malmquist, Malkah T. Notman
Journal: American Journal of Psychiatry (2001)

OBJECTIVE: Psychiatrist-patient relationships after termination of treatment are fraught with complexities and are the subject of ongoing debate. The authors discuss the issue of boundary violation allegations that arise after treatment has ended, with the goal of explicating how these issues have been handled in psychiatric discussions as well as in broader sociolegal settings. METHOD: Clinical illustrations and legal cases are used to illustrate how legal and administrative bodies have dealt with posttermination boundary issues. RESULTS: Courts and regulatory bodies have tended to use the psychoanalytic concept of transference to decide issues in which there has been a complaint of impropriety—be it romantic, financial, or social in nature—arising after termination of treatment. However, a multitude of treatment approaches are currently employed in psychiatry, and often their practitioners either do not use the concept of transference or deny its validity. If the concept is used, it is often present in many settings outside therapy. CONCLUSIONS: The concept of transference is subject to continuing debate and modification within psychoanalysis, and its use in judicial or quasijudicial settings raises questions about whether it meets standards of scientific acceptance. Using the concept of transference to decide posttermination issues results not only in confusion but also has the potential for many adverse consequences for practitioners and the profession.
Aneurysmal Dilatation of Portal Vein Demonstrated on Radionuclide Hepatic Scintiangiogram
Authors: T Aburano, M Taniguchi, K Hisada, Y Miyazaki, J Shiozaki, H Inoue, M Fujioka
Journal: Clinical Nuclear Medicine (1991)

The use of routine scintiangiography with a Tc-99m colloid liver scan is well documented. The authors present a case of aneurysmal dilatation of the portal vein demonstrated on the radionuclide hepatic scintiangiogram. During the portal phase, localized increased perfusion activity was persistently observed in the area of the porta hepatis, shown as a round defect on the static liver image.
A CASE OF COMPLICATED LABOR.
Authors: J. F. JENKINS
Journal: JAMA (1892)

Mrs. G., aged 21 years, a pripara, had suffered some inconvenience, as she stated, on account of her limbs being swollen, but otherwise was in good health. My first visit to the patient was about forty-eight hours previous to labor; the membranes had ruptured previously while the woman was about her work, and a large quantity of water escaped per vagina, although it was not preceded or followed by pain. The patient did not complain of headache, nor were there any nervous symptoms present, yet the face and limbs were cedematous, and would pit upon pressure, which was ascertained from examination of the urine to originate from nephritis. An examination per vagina found the cervix dilated to the size of a ten-cent piece. I left the patient, after instructing the attendant that whenever a change should take place in the condition of the woman to immediately inform me. The following
Rapid onset of multifocal human papillomavirus 72-associated oral intraepithelial neoplasia in a human immunodeficiency virus-infected patient
Authors: A. Kreuter, N.H. Brockmeyer, P. Altmeyer, H. Pfister, U. Wieland
Journal: British Journal of Dermatology (2007)

Journal Article Rapid onset of multifocal human papillomavirus 72‐associated oral intraepithelial neoplasia in a human immunodeficiency virus‐infected patient Get access A. Kreuter, A. Kreuter Department of Dermatology and Allergology, Ruhr‐University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany Search for other works by this author on: Oxford Academic Google Scholar N.H. Brockmeyer, N.H. Brockmeyer Department of Dermatology and Allergology, Ruhr‐University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany Search for other works by this author on: Oxford Academic Google Scholar P. Altmeyer, P. Altmeyer Department of Dermatology and Allergology, Ruhr‐University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany Search for other works by this author on: Oxford Academic Google Scholar H. Pfister, H. Pfister Institute of Virology, University of Cologne, Cologne, Germany E‐mail: a.kreuter@derma.de Search for other works by this author on: Oxford Academic Google Scholar U. Wieland, U. Wieland Institute of Virology, University of Cologne, Cologne, Germany E‐mail: a.kreuter@derma.de Search for other works by this author on: Oxford Academic Google Scholar for the German Competence Network HIV/AIDS for the German Competence Network HIV/AIDS Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 157, Issue 4, 1 October 2007, Pages 826–828, https://doi.org/10.1111/j.1365-2133.2007.08097.x Published: 01 October 2007
Hasty transfers from stroke units are "jeopardising" recovery, audit finds
Authors: O. Mashta
Journal: BMJ (2010)

Many patients who have had a stroke are transferred too quickly from specialist stroke units to intermediate care beds in non-specialist hospitals, jeopardising their recovery, says a new audit report by the Royal College of Physicians.

Although acute care of patients who have had a stroke has improved, post-acute services have not kept up, says the report, which focused on follow-up care after patients are discharged.

Access to long term rehabilitation services, especially those aimed at helping people return to work, is lacking, showed the audit, which was commissioned by the Healthcare Quality Improvement Partnership, a consortium of the Academy of Medical Royal Colleges, the Royal …