tbuckley/cabot-search huggingface dataset:
Hemodynamic Effects of Nonionic Contrast Bolus Injection and Oxygen Inhalation During Pulmonary Angiography in Patients With Chronic Major-Vessel Thromboembolic Pulmonary Hypertension
Authors: Michael Bernhard Pitton, Christoph Du¨ber, Eckhard Mayer, Manfred Thelen
Journal: Circulation (1996)

Background Pulmonary angiography is the gold standard for the diagnosis of chronic thromboembolic pulmonary hypertension; however, major complications have been reported. This study evaluates the hemodynamic effects of direct pulmonary nonionic contrast bolus injection and oxygen inhalation in patients with chronic thromboembolic pulmonary hypertension. Methods and Results In 33 patients, hemodynamic parameters were measured after oxygen inhalation and during bolus injection of nonionic contrast medium in a control group (group 1, n=11), in a group of patients with moderately severe pulmonary hypertension (group 2, n=9), and in a group with severe pulmonary hypertension (group 3, n=13). Oxygen inhalation significantly improved oxygen supply. Pulmonary artery pressure and heart rate were reduced, but pulmonary vascular resistance and total pulmonary resistance were not significantly affected. One hundred ninety-eight angiograms were performed selectively on both pulmonary arteries in the posterior-anterior, oblique, and lateral views. Before contrast bolus injection, RAP and PAP significantly increased because of initial inspiration. Contrast bolus injection caused only a minor pressure increase (ΔPA systolic, 2.3±1.4, 2.5±1.8, and 5.0±5.2 mm Hg, groups 1, 2, and 3, respectively) without significance between the groups. After the angiography, pulmonary artery pressure was moderately increased, predominantly in group 3, but pulmonary vascular resistance was not significantly changed. Systemic vascular resistance was decreased. Cardiac index increased in groups 1 and 2 but was unchanged in group 3. Systemic pressure therefore decreased in group 3. Conclusions We concluded that bolus injection of nonionic contrast medium causes no major hemodynamic effects even in patients with severe chronic thromboembolic pulmonary hypertension. Oxygen contributes to safety during the procedure.
Arterial Embolotherapy for Endoscopically Unmanageable Acute Gastroduodenal Hemorrhage: Predictors of Early Rebleeding
Authors: Romaric Loffroy, Boris Guiu, Philippe D'Athis, Lise Mezzetta, Alice Gagnaire, Jean–Louis Jouve, Pablo Ortega–Deballon, Nicolas Cheynel, Jean–Pierre Cercueil, Denis Krausé
Journal: Clinical Gastroenterology and Hepatology (2009)
Early postinfarction ischemia: clinical, angiographic, and prognostic significance.
Authors: X Bosch, P Théroux, D D Waters, G B Pelletier, D Roy
Journal: Circulation (1987)

Early ischemia, defined as angina with transient ST-T changes during hospitalization, 24 hr or more after an acute myocardial infarction (MI), was observed in 79 (18%) of a consecutive series of 449 patients surviving an MI and catheterized a mean of 10 +/- 3 days after admission. Three clinical factors present 24 hr after admission could identify patients at low, medium, and high risk of factors had a risk greater than 50% and the 118 patients with Q wave MI, no previous angina, and absence of risk factors had a risk of less than 8%. The angiographic correlates of early ischemia were number of vessels with 70% or more stenosis (2.1 +/- 0.8 vs 1.7 +/- 0.8/patient, p less than .0001), number of diseased coronary artery segments (2.8 +/- 1.4 vs 2.1 +/- 1.2, p less than .0001), left anterior descending coronary involvement (77% vs 62% of patients, p = .01), number of normally contractile segments at jeopardy because of a coronary stenosis (1.9 +/- 1.3 vs 1.3 +/- 1.1/patient, p less than .0002), collateral circulation at jeopardy (24% vs 15% of patients, p less than .005), and fewer collateral vessels distal to a tight stenosis (59 vs 72% of patients, p = .04). The stepwise logistic regression retained one angiographic and two clinical independent predictors of early ischemia: number of diseased vessels (p = .0008), presence of a non-Q wave MI (p = .0027), and previous angina (p = .017).(ABSTRACT TRUNCATED AT 250 WORDS)
The Eye and Systemic Disease
Authors: Lawrence W Hirst
Journal: JAMA (1980)

This book is a second edition, updating material originally presented at an international symposium by the Department of Ophthalmology, University of Iowa, Iowa City, in 1974. The format is that of a series of topics discussed in each instance by an internist and ophthalmologist, with panelists' questions and answers included. The topics include the involvement of the eye in diseases such as systemic infections, inborn errors of metabolism, collagen and rheumatic diseases, nutritional disorders, diabetes mellitus, and dermatologic, endocrine, hematologic, and vascular diseases. There is an impressive list of contributors to this symposium. Unfortunately, in common with many compilations of symposium proceedings, the quality of the material is variable. This includes marked variation in referencing of individual papers (ranging from 18 references for chapter 2 to 445 references for chapter 17), a wide disparity of space allocated to ocular disorders that have a poorly defined relation to systemic diseases (approximately
Recurrent Pleural Transudate in the Nephrotic Syndrome
Authors: Paul G. Jenkins
Journal: JAMA (1974)

PLEURAL transudates are a common feature of salt-retaining conditions. Little has been written, however, about the therapy for intractable or recurrent extensive pleural transudates. We report a case successfully treated by tetracyclineinduced pleural symphysis. <h3>Report of a Case</h3> A 70-year-old white woman was admitted to the University of Wisconsin Hospital in May 1971 for evaluation of the nephrotic syndrome and rapidly progressing renal failure. She was normotensive, weighed 110 kg (224 lb), and had pretibial edema (4+ ). The serum creatinine level was 10.1 mg/100 ml, and the serum albumin level was 1.8 gm/100 ml. Creatinine clearance was 6 ml/min, and protein excretion was 8 gm/day. Test for antinuclear antibody was negative. A chest x-ray film showed cardiomegaly with bilateral pleural effusions. A renal biopsy specimen disclosed sclerosis of 8 of 26 glomeruli seen with mesangial hypercellularity and widening in the others. Hemodialysis was begun, and the patient rapidly lost 13
Peutz-Jeghers Syndrome With Colonic Adenocarcinoma and Ovarian Tumor
Authors: Arthur L. Humphries
Journal: JAMA (1966)

PEUTZ-JEGHERS syndrome consists of intestinal polyps and intraoral melanin spots and is said to be hereditary. It was described in 1921 by Peutz, 1 and more recently (1949) by Jeghers et al. 2 It has since been recognized frequently, and at least 300 cases have been reported. The subject was reviewed in the medical literature several times. 3-6   The following case is presented because of the unusual combination of the Peutz-Jeghers syndrome and an ovarian neoplasm. Furthermore, one polyp of the colon removed eight years ago was malignant. The patient is now well and symptom free.  Report of a Case  In 1958, this 41-year-old Negro woman entered the Eugene Talmadge Memorial Hospital of the Medical College of Georgia because of pain in the left costovertebral angle, dysuria, and urinary urgency. The results of urinalyses were normal except for a few white blood cells found in the urine. The residual urine
Stool Polymerase Chain Reaction for Helicobacter pylori Detection and Clarithromycin Susceptibility Testing in Children
Authors: Andreas Vécsei, Albina Innerhofer, Christa Binder, Heidi Gizci, Karin Hammer, Andrea Bruckdorfer, Stefan Riedl, Helmut Gadner, Alexander M. Hirschl, Athanasios Makristathis
Journal: Clinical Gastroenterology and Hepatology (2009)
Carney complex: A clinicopathologic and molecular biological study of a sporadic case, including extracutaneous and cutaneous lesions and a novel mutation of the PRKAR1A gene
Authors: Denisa Kacerovska, Radek Sima, Michal Michal, Ondrej Hes, Patrik Roucka, Marta Zarybnicka, Milan Hora, Zdenek Chudacek, Dmitry V. Kazakov
Journal: Journal of the American Academy of Dermatology (2009)
Metered dose inhalers. Safe if used properly.
Authors: F G Simpson
Journal: BMJ (1993)

EDrrOR,-Some of the issues raised by Bonneux and Barendregt have already been addressed in the discussion section of our paper.There is a fundamental misapprehension contained in Bonneux and Barendregt's second paragraph.Their argument is valid only if this department is assumed to have been responsible for all the cases of gastric cancer from a defined population.
On the Employment of Atropine in Correcting Errors of Refraction
Authors: A. Critchett
Journal: BMJ (1882)

In the case of tb6 patient who Was operated upon, the existence of true hypertrophy of thellip was manifest.It cannot, therefore, be in- cluded among the instances in which the thickening is due to an in- crease in the size of the natural glands of the part, and which are stated by Mr. Bryant (Practice of Surgery; vol.i, pp. 492-3),to be often found both in the upper and lower lip.-With regard to the presence of, sacculi, the cases of the patient,; her mother, and brothers and sisters, bear a very close resemblance to those related by Mr. Jardine Murray (Britishz and For-eign AfMedical
Dominant unit CD34+ cell dose predicts engraftment after double-unit cord blood transplantation and is influenced by bank practice
Authors: Duncan Purtill, Katherine Smith, Sean Devlin, Richard Meagher, Joann Tonon, Marissa Lubin, Doris M. Ponce, Sergio Giralt, Nancy A. Kernan, Andromachi Scaradavou, Cladd E. Stevens, Juliet N. Barker
Journal: Blood (2014)
Abstract P4-06-04: Effect of genomic heterogeneity on breast cancer progression and metastatic spread
Authors: RE Ellsworth, AL Valente, HL Blackburn, A Decewicz, B Deyarmin, K Mamula, CD Shriver, DL Ellsworth
Journal: Cancer Research (2013)

Abstract Purpose: DNA fingerprinting has revealed discordant patterns of chromosomal alterations in primary breast tumors (PBT) compared to matched metastatic axillary lymph node tumors (MLNT); however, whether these genetic differences reflect the timing of dissemination of cells with metastatic potential from the primary tumor, intratumoral heterogeneity of the primary breast tumor, or independent seeding of lymph nodes with metastatic cells remains unclear. Patients and Methods: From the 30 node-positive patients evaluated in this study, allelic imbalance (AI) data was generated using 52 microsatellite markers from 5-19 areas of each PBT as well as from available MLNT. Data were analyzed using pairwise correlations, ANOVA and PHYLIP. Results: The frequency of genomic changes was significantly higher (P&amp;lt;0.001) in PBT areas (13%) than MLNT (9%). No two PBT areas had identical patterns of AI and the percent concordance (PC) of AI events between tumor regions ranged from 0-65% (average 33%). Of the 196 MLNT from 28 patients, PC between MLNT from the same patient ranged from 0-88% (average = 32%). Neither the overall frequency of AI nor the PC differed significantly between sentinel (SLN) and non-SLNs. Phylogenetic analysis revealed that within patients, many MLNT appeared to be descended from different areas of the PBT, but patterns of descent were complex. Conclusions: Both PBT and MLNT are characterized by extensive molecular heterogeneity, MLNT appear to originate from different areas of the PBT, and SLN metastases are not genomically more advanced than non-SLN metastases. These data suggest that metastatic dissemination may be influenced by both spatial and temporal factors, with cells with metastatic potential colonizing lymph nodes throughout the development of the PBT, and that SLN metastases do not appear to be a source of metastatic cells for non-SLN but rather MLNT arise by independent colonization. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P4-06-04.
LICHEN AMYLOIDOSIS.
Authors: C. H. TAY, J. L. DACOSTA
Journal: British Journal of Dermatology (1970)

SUMMARY.— Forty cases of lichen amyloidosis were found in 2 medical units in a Singapore general medical hospital over a 3-year period. The majority of the patients were middle-age Chinese females with a long standing history (over 20 years) of the disease. Pruritus was significantly absent in 37·5%. The common cutaneous lesions were papules (62·5%) and plaques (22·5%) found mostly on the shins and thighs (90%). A number of precipitating factors and associated skin diseases were noted, but their relationship to lichen amyloidosis is obscure. Treatment with intralesional and topical steroids is discussed.
Antenatal Diagnosis and Therapeutic Trends in Sphingolipidoses
Authors: Larry Schneck
Journal: JAMA (1974)

OF the 1,500 distinguishable human diseases that are genetically determined, a recent review compiled more than 40 for which a prenatal diagnosis was potentially possible.<sup>1</sup>This register includes diseases caused by chromosomal aberrations, sex-linked diseases, and metabolic disorders. In contrast to diseases that involve the interaction or blending of many different aberrant genes—polygenetic or multifactorial diseases—and usually appear somewhat later in life (eg, diabetes and atherosclerosis), metabolic diseases usually involve single gene mutations and adhere to the precepts of mendelian genetics. This means that armed with the appropriate information in regard to the dominant and recessive genetic traits, one can predict the statistical probability of the genetic nature of the offspring in regard to the disease entity. In biochemical terms, the best understood group of genetic diseases are those in which a single gene mutation is involved, usually affecting the expression of an enzyme, hormone, or a particular protein.
Some Aspects of Carditis
Authors: T. F. Cotton, C.M. McGill
Journal: BMJ (1942)

I shall dewribe in this paper certain symptoms and signs which have helped me in the management and treatment of patients, particularly children, with rheumatic heart disease.I have also some observations to make on prognosis, based on the after-history records of children over a 10-years period.The symptom-complex of rheumatic fever does not present a uniform clinical picture.There is a monocyclic type with pyrexia, toxaemia, sweating, leucocytosis, and migrating poly- arthritis; the heart may not be affected, and recovery is complete after a week or ten days of acute illness and three weeks of convalescence.In some these acute symptoms develop after a throat infection and two or three weeks of low-grade fever.There may be a second similar cycle of symptoms without cardiac involvement.Some have a persistent irregular tempera- ture not rising above 100' or 1610, and there are rare cases with hyperpyrexia (Coburn, 1931).Fever is the most constant of rheumatic phenomena.There may be no arthritis and no cardiac or other visceral manifestations of infection.Tachycardia, like pyrexia, is evidence of a general infection, and not necessarily due to the cardiac lesion; its relation to active carditis, except in advanced disease, may not be that of infection of heart muscle or valve, but the indirect effect of toxaemia on heart rate. REACTIONS AFTER TRANSFUSIONS OF STOREDBLOOD BRITISH MEDICAL JOURNALChildren with moderate or considerable enlargement of the heart are less likely to live 10 years than those with slight or no enlargement.
Association of Poly(Adenosine Diphosphoribose) Synthesis with DNA Damage and Repair in Normal Human Lymphocytes
Authors: Nathan A. Berger, Georgina W. Sikorski, Shirley J. Petzold, Kevin K. Kurohara
Journal: Journal of Clinical Investigation (1979)

A permeable cell technique was used to measure the alterations in synthesis of DNA and poly-(adenosine diphosphoribose) in normal human lymphocytes after treatment of the cells with different types of DNA-damaging agents. The lymphocytes showed an abrupt increase in the unscheduled synthesis of DNA and poly(adenosine diphosphoribose) in response to ultraviolet (UV) irradiation. The increases were apparent within 1 h and reached a maximum between 2 and 4 h after irradiation. The magnitude of the increases in DNA and poly(adenosine diphosphoribose) synthesis was dependent upon the UV dose. Alkaline CsCl gradient studies, with bromodeoxyuridine triphosphate density labeling of DNA, demonstrated that the unscheduled DNA synthesis, which occurred in response to UV irradiation, was actually a result of the repair mode of DNA synthesis. Similar increases in DNA synthesis, and poly(adenosine diphosphoribose) synthesis occurred when lymphocytes were treated with several other DNA-damaging agents, including bleomycin, N-methyl-N′-nitro-N-nitrosoguanidine or N-acetoxyacetyl aminofluorene. Treatment of lymphocytes with DNase, under conditions which allowed degradation of cellular DNA, also resulted in increased synthesis of poly(adenosine diphosphoribose). Cycloheximide did not inhibit the increase in synthesis of DNA or poly(adenosine diphosphoribose) that occurred in response to treatment with the DNA-damaging agents.
Aspirin-Induced Hepatic Encephalopathy and Chronic Liver Disease
Authors: ANDREW I. LAZAROVITS
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 September 1980Aspirin-Induced Hepatic Encephalopathy and Chronic Liver DiseaseANDREW I. LAZAROVITS, B.SC., M.D., GEOFFREY M. ROBINSON, M.B., CH.B., PAUL DEVENYI, M.D.ANDREW I. LAZAROVITS, B.SC., M.D.Search for more papers by this author, GEOFFREY M. ROBINSON, M.B., CH.B.Search for more papers by this author, PAUL DEVENYI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-3-510_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Hepatocellular toxicity secondary to aspirin has been reported (1-4), but to our knowledge the drug has not been implicated as a precipitant of hepatic encephalopathy in adults. We report the case of a patient with chronic alcoholic liver disease who developed hepatic encephalopathy secondary to aspirin toxcity, which was reproduced by a rechallenge experiment.A 56-year-old chronic alcoholic woman with biopsy-proven micronodular cirrhosis was admitted with hepatic encephalopathy. She had been taking approximately 5 g of aspirin per day for severe left hip pain due to progressive osteoarthritis. She had not been drinking ethanol for a month...References1. SEAMAN W, ISHAK K, and PLOTZ P. Aspirin-induced hepatotoxicity in patients with systemic lupus erythematosus. Ann Intern Med. 1974;80:1-8. LinkGoogle Scholar2. WOLFE J, METZGER A, and GOLDSTEIN R. Aspirin hepatitis. Ann Intern Med. 1974;80:74-6. LinkGoogle Scholar3. MANSO C, TARANTA A, and NYDICK I. Effect of aspirin administration on serum glutamic oxaloacetic and glutamic pyruvic transaminases in children. Proc Soc Exp Biol Med. 1956;93:84-8. CrossrefMedlineGoogle Scholar4. RICH P and JOHNSON J. Salicylate hepatotoxicity in patients with juvenile rheumatoid arthritis. Arthritis Rheum. 1973;16:1-9. CrossrefMedlineGoogle Scholar5. PRESCOTT L. Antipyretic analgesics. In: DUKES MNG., ed.: Side Effects of Drugs Annual 1. Amsterdam: Exerpta Medica; 1977:66. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ANDREW I. LAZAROVITS, B.SC., M.D.; GEOFFREY M. ROBINSON, M.B., CH.B.; PAUL DEVENYI, M.D.Affiliations: Addiction Research Foundation University of Toronto Toronto, Ontario Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySevere hepatoxicity caused by aspirin overdose: a case report 1 September 1980Volume 93, Issue 3 Page: 510-510 Keywords Alcoholics Aspirin Brain diseases Chronic liver disease Cirrhosis Ethanol Hip Liver diseases Osteoarthritis Toxicity ePublished: 1 December 2008 Issue Published: 1 September 1980 PDF downloadLoading ...
Exhaled Breath Profiling Enables Discrimination of Chronic Obstructive Pulmonary Disease and Asthma
Authors: Niki Fens, Aeilko H. Zwinderman, Marc P. van der Schee, Selma B. de Nijs, Erica Dijkers, Albert C. Roldaan, David Cheung, Elisabeth H. Bel, Peter J. Sterk
Journal: American Journal of Respiratory and Critical Care Medicine (2009)

Rationale: Chronic obstructive pulmonary disease (COPD) and asthma can exhibit overlapping clinical features. Exhaled air contains volatile organic compounds (VOCs) that may qualify as noninvasive biomarkers. VOC profiles can be assessed using integrative analysis by electronic nose, resulting in exhaled molecular fingerprints (breathprints).Objectives: We hypothesized that breathprints by electronic nose can discriminate patients with COPD and asthma.Methods: Ninety subjects participated in a cross-sectional study: 30 patients with COPD (age, 61.6 ± 9.3 years; FEV1, 1.72 ± 0.69 L), 20 patients with asthma (age, 35.4 ± 15.1 years; FEV1 3.32 ± 0.86 L), 20 nonsmoking control subjects (age, 56.7 ± 9.3 years; FEV1, 3.44 ± 0.76 L), and 20 smoking control subjects (age, 56.1 ± 5.9 years; FEV1, 3.58 ± 0.78). After 5 minutes of tidal breathing through an inspiratory VOC filter, an expiratory vital capacity was collected in a Tedlar bag and sampled by electronic nose. Breathprints were analyzed by discriminant analysis on principal component reduction resulting in cross-validated accuracy values (accuracy). Repeatability and reproducibility were assessed by measuring samples in duplicate by two devices.Measurements and Main Results: Breathprints from patients with asthma were separated from patients with COPD (accuracy 96%; P < 0.001), from nonsmoking control subjects (accuracy, 95%; P < 0.001), and from smoking control subjects (accuracy, 92.5%; P < 0.001). Exhaled breath profiles of patients with COPD partially overlapped with those of asymptomatic smokers (accuracy, 66%; P = 0.006). Measurements were repeatable and reproducible.Conclusions: Molecular profiling of exhaled air can distinguish patients with COPD and asthma and control subjects. Our data demonstrate a potential of electronic noses in the differential diagnosis of obstructive airway diseases and in the risk assessment in asymptomatic smokers.Clinical trial registered with www.trialregister.nl (NTR 1282).
Biliary heavy metal concentrations in carcinoma of the gall bladder: case-control study
Authors: V K Shukla, A Prakash, B D Tripathi, D C S Reddy, S Singh
Journal: BMJ (1998)

Carcinoma of the gall bladder is the third most common malignancy of the gastrointestinal tract in the eastern Uttar Pradesh and western Bihar regions of India.1 The two regions lie down stream of the river Ganges, which is the main source of drinking, bathing, and irrigation water in this part of India and receives untreated domestic sewage and industrial and agricultural effluent. High concentrations of cadmium have been reported in sewage, irrigation water, and vegetables grown in the area, and higher concentrations of heavy metals than recommended by the World Health Organisation have been reported in water from this region. Heavy metals as environmental pollutants have been implicated in human carcinogenesis.2 These metals, especially cadmium, are excreted and concentrated in the hepatobiliary system.3

We investigated whether gallbladder cancer was associated with exposure to heavy metals and hence high biliary …
Cardiac tamponade or hemopericardium are not associated with bleeding risk factors in consecutive patients hospitalized with noniatrogenic, pericardial effusions
Authors: Bryan A. Faller, Qin Zhang, Joel Picus
Journal: American Journal of Hematology (2010)

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