tbuckley/cabot-search huggingface dataset:
Fate of Cardiology Research Originally Published in Abstract Form
Authors: Lee Goldman, Anita Loscalzo
Journal: New England Journal of Medicine (1980)

Abstract A computerized search of 276 randomly selected cardiology abstracts published in conjunction with three national meetings revealed that 137 abstracts (49.6 per cent) led to full-length articles in peer-reviewed journals within a period of 37 to 43 months. The median interval between publication of the abstract and of the article was 14 months. Full-length articles were derived from 59 per cent of the abstracts presented at the meetings of the American Federation for Clinical Research, the American Society for Clinical Investigation, and the Association of American Physicians ("clinical societies"); 55 per cent of the abstracts presented at the American Heart Association Scientific Sessions; 49 per cent of the abstracts presented at the American College of Cardiology Scientific Sessions; and 35 per cent of the abstracts submitted to the clinical societies but not presented. During the observation period, each abstract was cited a mean of 1.6 times in a journal reference list; the number of citations was not significantly higher for abstracts that led to articles than for abstracts that did not. These findings emphasize the preliminary nature of abstracts and suggest restraint in their citation as references. (N Engl J Med. 1980; 303:255–9.)
Reperfusion injury: A role for neutrophils
Authors: John J. Lemasters, Ronald G. Thurman
Journal: Hepatology (1991)

To determine the role of neutrophils in the pathogenesis of hepatic ischemia/reperfusion injury, livers from male Fischer rats were subjected to 45 min of no-flow ischemia followed by reperfusion for up to 24 h. Two phases of liver injury were identified, an initial phase during the first hour of reperfusion and a later progression phase with 80 ± 3% hepatocyte necrosis and an 80-fold increase of neutrophil infiltration in the liver after 24 h. Pretreatment with a monoclonal antibody against neutrophils, which caused consistent neutropenia, protected the liver from reperfusion injury as indicated by 28 ± 10% necrosis, and 84% reduction of hepatic neutrophil accumulation and a complete recovery of the hepatic ATP content. Our data suggest that the later progression phase of reperfusion injury after hepatic no-flow ischemia is mediated mainly by neutrophils.
PTU-179 Diagnostic Yield of Eus-Fna in Pancreatic Neuro-Endocrine Tumours (PNET) – Solid Versus Cystic Pnets – 9 Year Experience from a Tertiary Centre: Abstract PTU-179 Table 1
Authors: V Mitra, M Nayar, J Leeds, B Haugk, V Wadehra, R Charnley, B Jaques, S White, D Manas, J French, K Oppong
Journal: Gut (2013)

<h3>Introduction</h3> The detection and diagnosis of pNETs remains challenging. EUS and EUS-FNA has a significant role in the detection, precise localisation and cytological confirmation of pNETs. <h3>Methods</h3> A retrospective review of all pNET patients undergoing EUS-FNA between April 2003 and September 2011 was carried out to determine the efficacy of EUS-FNA in confirming pNETs and compare performance over two consecutive 4 year period. <h3>Results</h3> 10 patients (3% of EUS procedures for cystic lesions) with cystic pNETs and 44 (4% of EUS procedures for solid lesions) with solid pNETs were identified. Table 1 compares the size, demographics and diagnostic performance of radiology, EUS &amp; cytology in solid and cystic pNETs. 17 and 5 solid and cystic pNETs respectively were diagnosed between 2003 and 2007 while 27 and 5 solid and cystic pNETs were diagnosed between 2008 and 2011. EUS-FNA diagnosis of cystic and solid pNETs has improved from 20% and 59% respectively between 2003 and 2007 to 100% and 81% respectively between 2008 and 2011. Overall, sensitivity of EUS cytology has improved from 50% to 84.4% (p = 0.015) during this period. Malignant potential of solid pNETs was higher (54.5% vs 20%) compared to cystic pNETs. Curative resection was higher in patients with cystic pNETs (80% vs 68%) compared to solid pNETs. <h3>Conclusion</h3> EUS &amp; EUS-FNA is a useful test in diagnosing pNETs. Overall, the sensitivity of combined EUS imaging and cytology was significantly better compared to CT/MRI (p &lt; 0.05) in detecting pNETs across all groups. Sensitivity of combined EUS imaging and cytology was significantly better compared to EUS imaging alone (p &lt; 0.05) in the solid and combined pNET cohort of patients. Sensitivity of EUS cytology was significantly better compared to EUS imaging (p &lt; 0.05) in the solid and combined pNET cohort of patients. Comparing the first 4 years to the second, there has been an increase in the number of cases of pNETs and statistically significant improvement in the diagnostic performance of cytology. <h3>Disclosure of Interest</h3> None Declared.
Abstract 5153: PAK2-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation.
Authors: Tingting Li, Jishuai Zhang, Feng Zhu, Weihong Wen, Tatyana Zykova, Xiang Li, Kangdong Liu, Cong Peng, Wei-Ya Ma, Zigang Dong, Ann M. Bode
Journal: Cancer Research (2013)

Abstract PAK2 plays an important role in cell proliferation, but the direct downstream proteins and precise regulatory mechanism involved in mediating PAK2’s role in proliferation are not yet clear. Here, we found that epidermal growth factor (EGF) induces phosphorylation of c-Jun by P21-activated kinase (PAK2). Knockdown of PAK2 in JB6 Cl41 (P+) cells had no effect on c-Jun phosphorylation at Ser63 or Ser73 but resulted in decreases in EGF-induced anchorage-independent cell transformation, proliferation and AP-1 activity. The oncoprotein c-Jun is one of the components of the activator protein-1 (AP-1) transcription factor complex. AP-1 activates a variety of tumor-related genes and promotes tumorigenesis and malignant transformation. Knockdown of PAK2 in SK-MEL-5 melanoma cells also decreased colony formation, proliferation and AP-1 activity. We found that PAK2 binds and phosphorylates c-Jun at five threonine sides (Thr2, Thr8, Thr89, Thr93 and Thr286) in vitro and in vivo. Mutation at all five sites decreased the transforming ability of JB6 cells. These results indicated that PAK2/c-Jun signaling plays an important role in tumorigenesis and provides an increased understanding of the signaling transduction mechanism of skin tumor cells and suggests that PAK2 might be a new chemopreventive or chemotherapeutic target. Citation Format: Tingting Li, Jishuai Zhang, Feng Zhu, Weihong Wen, Tatyana Zykova, Xiang Li, Kangdong Liu, Cong Peng, Wei-Ya Ma, Zigang Dong, Ann M. Bode. PAK2-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5153. doi:10.1158/1538-7445.AM2013-5153
Tuberculous Rheumatism: Report of a Case
Authors: P. G. Dalgleish
Journal: Annals of the Rheumatic Diseases (1952)

Poncet (1897) first drew attention to the poly- arthritis that sometimes accompanies tuberculosis, and the condition was described more fully by Poncet and Mailland (1903) and Poncet and Leriche (1909).In France and Germany reports of such cases have frequently been made, but in Great Britain they are uncommon and consequently the following case is thought worthy of record.Case Report History.-Thepatient, a girl aged 17, first seen as an out-patient in November, 1950, was complaining of pain, stiffness, and swelling of 2 months' duration in her knees, ankles, and fingers.There had also been vague pains in her shoulders and hips.She had been quite well until June, 1950, when she developed-some lumbar backache,
The effects of topical calcipotriol on systemic calcium homeostasis in patients with chronic plaque psoriasis
Authors: J.F. Bourkea, R. Mumforda, P. Whittaker b, S.J. Iqbalb, L.W. Le Vand, A. Trevellyan c, P.E. Hutchinsona
Journal: Journal of the American Academy of Dermatology (1997)
Supplementary Imaging for Breast Cancer Screening in High-Risk Women—Reply
Authors: Wendie A. Berg, Richard G. Barr, Zheng Zhang
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of armed conflict on access to emergency health care in Palestinian West Bank: systematic collection of data in emergency departments
Authors: Maren Johanne Heilskov Rytter, Anne-Lene Kjældgaard, Henrik Brønnum-Hansen, Karin Helweg-Larsen
Journal: BMJ (2006)

Joint analysis of multiple single cell RNA-sequencing (scRNA-seq) data is confounded by technical batch effects across experiments, biological or environmental variability across cells, and different capture processes across sequencing platforms. Manifold alignment is a principled, effective tool for integrating multiple data sets and controlling for confounding factors. We demonstrate that the semi-supervised t-distributed Gaussian process latent variable model (sstGPLVM), which projects the data onto a mixture of fixed and latent dimensions, can learn a unified low-dimensional embedding for multiple single cell experiments with minimal assumptions. We show the efficacy of the model as compared with state-of-the-art methods for single cell data integration on simulated data, pancreas cells from four sequencing technologies, stem cells from male and female donors, and mouse brain cells from both spatial seqFISH+ and traditional scRNA-seq.
TCT-128 Transcatheter Implantation of Self-Expandable Vena Cava Valves for Treatment of Tricuspid Regurgitation: First-Human-Case Description
Authors: Hans R. Figulla, Torsten Doenst, Marcus Franz, Ali Hamadanchi, Daniel Kretzschmar, Alexander Lauten
Journal: Journal of the American College of Cardiology (2013)
New public health agency sets out its stall
Authors: S. Pincock
Journal: BMJ (2003)

The new public health organisation for England and Wales, the Health Protection Agency, has set itself a wide range of priorities for the next five years, saying that the rapid spread of severe acute respiratory syndrome (SARS) highlighted the pressing need for better ways to tackle emerging threats.

“The global threats to health have moved on and so must we—it's time to step up our health defences,” said the agency's chairman, William Stewart, launching the agency's corporate plan last Tuesday. “The SARS experience demonstrated that a new bug can spread around the world in days.”

The agency outlined 12 strategic goals, ranging from boosting preparedness …
Heat Effects Are Unique: Mortality Risk Depends on Heat Wave, Community Characteristics
Authors: Tanya Tillett
Journal: Environmental Health Perspectives (2011)

Polybrominated diphenyl ether (PBDE) flame retardants and their hydroxylated metabolites are structurally similar to thyroid hormone.A detailed study now provides one of the most insightful assessments to date of how environmentally relevant levels of PBDEs may impair brain development by interfering with thyroid hormone receptor (TR)-mediated transcription [EHP 119(2):168-175; Ibhazehiebo et al.].PBDEs were used for decades as flame retardants in a wide variety of consumer and household goods, and U.S. citizens are
Rapid Cancer Detection by Topically Spraying a γ-Glutamyltranspeptidase–Activated Fluorescent Probe
Authors: Yasuteru Urano, Masayo Sakabe, Nobuyuki Kosaka, Mikako Ogawa, Makoto Mitsunaga, Daisuke Asanuma, Mako Kamiya, Matthew R. Young, Tetsuo Nagano, Peter L. Choyke, Hisataka Kobayashi
Journal: Science Translational Medicine (2011)

A spirocyclic-caged, small-molecule imaging probe fluoresces upon cleavage by a cancer-specific enzyme and can be used during surgical or endoscopic tumor removal procedures.
Stretch–Activation of Angiotensin II Type 1 <sub>a</sub> Receptors Contributes to the Myogenic Response of Mouse Mesenteric and Renal Arteries
Authors: Johanna Schleifenbaum, Mario Kassmann, István András Szijártó, Hantz C. Hercule, Jean-Yves Tano, Stefanie Weinert, Matthias Heidenreich, Asif R. Pathan, Yoland-Marie Anistan, Natalia Alenina, Nancy J. Rusch, Michael Bader, Thomas J. Jentsch, Maik Gollasch
Journal: Circulation Research (2014)

Rationale : Vascular wall stretch is the major stimulus for the myogenic response of small arteries to pressure. The molecular mechanisms are elusive, but recent findings suggest that G protein–coupled receptors can elicit a stretch response. Objective : To determine whether angiotensin II type 1 receptors (AT 1 R) in vascular smooth muscle cells exert mechanosensitivity and identify the downstream ion channel mediators of myogenic vasoconstriction. Methods and Results : We used mice deficient in AT 1 R signaling molecules and putative ion channel targets, namely AT 1 R, angiotensinogen, transient receptor potential channel 6 (TRPC6) channels, or several subtypes of the voltage-gated K + (K v 7) gene family (KCNQ3, 4, or 5). We identified a mechanosensing mechanism in isolated mesenteric arteries and in the renal circulation that relies on coupling of the AT 1 R subtype a to a G q/11 protein as a critical event to accomplish the myogenic response. Arterial mechanoactivation occurs after pharmacological block of AT 1 R and in the absence of angiotensinogen or TRPC6 channels. Activation of AT 1 R subtype a by osmotically induced membrane stretch suppresses an XE991-sensitive K v channel current in patch-clamped vascular smooth muscle cells, and similar concentrations of XE991 enhance mesenteric and renal myogenic tone. Although XE991-sensitive KCNQ3, 4, and 5 channels are expressed in vascular smooth muscle cells, XE991-sensitive K + current and myogenic contractions persist in arteries deficient in these channels. Conclusions : Our results provide definitive evidence that myogenic responses of mouse mesenteric and renal arteries rely on ligand-independent, mechanoactivation of AT 1 R subtype a. The AT 1 R subtype a signal relies on an ion channel distinct from TRPC6 or KCNQ3, 4, or 5 to enact vascular smooth muscle cell activation and elevated vascular resistance.
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
Authors: Jun Yamanouchi, Dan Rainbow, Pau Serra, Sarah Howlett, Kara Hunter, Valerie E S Garner, Andrea Gonzalez-Munoz, Jan Clark, Riitta Veijola, Rose Cubbon, Show-Ling Chen, Raymond Rosa, Anne Marie Cumiskey, David V Serreze, Simon Gregory, Jane Rogers, Paul A Lyons, Barry Healy, Luc J Smink, John A Todd, Laurence B Peterson, Linda S Wicker, Pere Santamaria
Journal: Nature Genetics (2007)
AIDS Policy Into the 1990s
Authors: Renslow Sherer
Journal: JAMA (1990)

A grim metaphor heard at the First International AIDS Conference in Atlanta in 1985 was that the acquired immunodeficiency syndrome (AIDS) was "a nightmare from which one can never awaken." It was actually two nightmares, in parallel: the syndromes of human immunodeficiency virus (HIV) disease and their attendant suffering and mortality, and a second epidemic of fear and discrimination. The power of those fears to disrupt lives was most vividly demonstrated by the experience of a family with three hemophiliac children. When the parents voluntarily disclosed the HIV antibody status of their sons, they were barred from the local public school and their church, socially ostracized, and finally driven from town when their home was burned (<i>New York Times</i>. August 31, 1987:1). Similar instances of violence and hatred perpetuated by irrational fears have been experienced by homosexual men, drug users, and others affected or perceived to be at risk. For
Joggers May Live Longer...
Authors: Norman M. Kaplan
Journal: JAMA (1984)

The universal admiration for athletic excellence, exemplified in the Olympics, caps an attitude about the value of physical exercise that is almost as pervasive. Unfortunately the evidence that physical exercise does more than make us feel better has been hard to come by. And for some, such as the anonymous author of the quote "Joggers don't live longer, it just seems like it," the benefits of physical exercise are not only unproved but unobtainable by most ordinary people. The article by Blair et al<sup>1</sup>in this issue ofThe Journalprovides some very suggestive evidence that physical fitness provides protection against the development of hypertension during the next one to 12 years. Those with low levels of physical fitness at the initial examination had a 1.52 greater relative risk for the development of hypertension than did those with higher levels of physical fitness, after appropriate adjustment for age, sex,
Psychiatric Help May Shrink Some Waistlines
Authors: L Lamberg
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The clinical and laboratory course of polymyalgia rheumatica/giant cell arteritis after the first two months of treatment.
Authors: V Kyle, B.L. Hazleman
Journal: Annals of the Rheumatic Diseases (1993)

To examine the clinical course of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) in a prospective study, after the initial two months. Seventy four patients with PMR/GCA were followed for a median of 60 weeks. Detailed clinical and laboratory records were made on each visit. Twenty per cent of patients with PMR developed GCA and 24% of patients with GCA developed PMR from the onset of symptoms. After two months, most patients experienced at least one relapse. Relapses and persistence of abnormal symptoms and signs were most common in patients with both PMR and GCA and least common in those with GCA alone. Relapses were most common in the first year and 54% occurred in association with steroid reduction. Major complications were rare. Laboratory parameters and temporal artery histology were not helpful in predicting relapse. Only 24% of patients were able to stop steroid treatment after two years. Clinicians should consider more frequent review in patients at times of steroid reduction and especially within the first six months of treatment.
Further Remarks on Albuminuria Resulting from Sewage Poisons
Authors: G. Johnson
Journal: BMJ (1888)

the cold applications could not be exclusively due to mere refrigeration, to simple abstraction of heat from the hodv byforce maj,eure.Naunyn lha(l insisted1 on this point, ani( hadi fuir- nish1ed goodI reasons, cliniical aniid experimental, in its slupport.The most efficienit method of keeping downi the temp>erature in typhoid was thle coltntiuouIs tepi(d bath of Riess, in whlich peatientx m wfere kept in water at 88°F. or so, for ten to twenty hours at at time.In this way the temperature might oscillate about the nornal througlhout thie gretater part of the, illness; yet Riess' ratte of mor- tality was not of the lowest.Including all cases, it was, on the average, 22 per cent.The same observer hiad previously forcibly sul)pressed pyrexia in his patienlts by the continuous use of stffi- cienit doses ot salicvlic acid, bLt, nlotwithistanintiiig, hle lost 24 per cent. of his cases.Other cases were given in illbustration, and the conclusion drawn that we muist seek for aii exl)lanationi of tle wholesome effects of coldl bathing in its influence oni the nervous system, transmittetd in the first instanice tlhrough the seunsory nerves.
Identifying Adverse Events Caused by Medical Care: Degree of Physician Agreement in a Retrospective Chart Review
Authors: A. Russell Localio
Journal: Annals of Internal Medicine (1996)

Objective: To 1) assess the degree of agreement among physicians on the cause of previously flagged adverse outcomes and 2) relate the findings to systems of quality assurance and performance assessment and proposals for no-fault compensation for medical injuries. Design: Observational study of 7533 pairs of "structured implicit" reviews (subjective opinions based on guidelines) of medical records done by 127 physicians working independently. Setting: Random sample of 51 inpatient facilities in New York State. Patients: Random sample of inpatient medical records from the selected facilities. Measurements: 1] Number of agreed-upon adverse events compared with the number of cases of extreme disagreement and 2) internally and indirectly standardized rates at which physician reviewers found adverse events (injuries to patients caused at least in part by medical management). Results: In 12.9% of cases (971 of 7533), the two physicians in a pair had extreme disagreement about the occurrence of an adverse event. These cases outnumbered those in which both reviewers found an adverse event (10%; n = 757). Agreement was highest for wound infections and lowest for adverse events attributed to failure to diagnose or lack of therapy. The amount of experience the physicians had in reviewing records tended to increase the level of agreement. Even after standardization to the results of the entire sample, individual physicians' rates of finding at least slight evidence of an adverse event varied widely (range, 9.9% to 43.7%) (P < 0.001). Conclusions: Structured implicit reviews produced disagreement on the causes of adverse patient outcomes. If systems of quality assurance, performance audits, or no-fault patient compensation are to succeed, methods for overcoming the common tendency toward disagreement among experts must be developed.