tbuckley/cabot-search huggingface dataset:
Marriage-Growth or Disaster?
Authors: WARREN L. JONES
Journal: American Journal of Psychiatry (1969)

The test of an individual's growth is his capacity to relate effectively and intimately to significant others. A challenge in adult life is to achieve a marriage that contains creative communication. It is necessary for an individual to be intact as a person in order for him to develop a capacity to relate empathically and knowingly with a mate. If this relating is mutual, a synergism of gratifying stimulation to each is the outcome. The psychiatrist's activity in conjoint therapy is to facilitate empathic communication and to assist with the working through of regressive, defensive investments within the marital relationship.
THE DUODENAL BUCKET
Authors: Moses Einhorn
Journal: JAMA (1927)

<h3>To the Editor:</h3> —InThe Journal, March 19, I published a letter in which I had occasion to criticize Dr. Sylvan D. Manheim for failing to give me proper credit while using a bucket which I innovated as a basis for his improvement. For the information of your readers and in justice to Dr. Manheim and myself, I wish to state that the dispute was referred for arbitration to a committee of three physicians from Mount Sinai Hospital who have decided that while I was first in the field with my bucket there was no evidence to show that Dr. Manheim deliberately infringed on my rights.
TREATMENT OF POISON IVY DERMATITIS
Authors: Don P. Flagg
Journal: JAMA (1923)

ABSTRACT To the Editor: —A perusal of Dr. Tieken's article in Hygeia on poison ivy and its treatment causes me to give my experience with the poisonous sumacs and their treatment. I have found melted wax to afford instant relief from pain, burning and itching in young and old, even with severe involvement of the rectal and vaginal mucosa. The course of the dermatitis is much shortened. A simple and easy method is to use a small swab with cotton and paint the parts with the melted wax. There is no danger, of course, from burning. With closed eyes the whole face may be painted. The least entrance of air beneath the mask or cast of wax necessitates sealing in the weakened part. I know from personal experience the instant relief from pain, burning and itching and the return of sleep which is so grateful to the patient, to say nothing
RETRACTED: The Fas/Fas Ligand Pathway and Bcl-2 Regulate T Cell Responses to Model Self and Foreign Antigens
Authors: Luk Van Parijs, Daniel A Peterson, Abul K Abbas
Journal: Immunity (1998)

We have examined the role of Fas and Bcl-2 in T cell survival and responses to antigen in vivo using T cells that express a transgenic antigen receptor specific for hen egg lysozyme (HEL) and that either lack functional Fas or Fas ligand (FasL) or overexpress Bcl-2 as a transgene. HEL-specific, Bcl-2-transgenic T cells showed prolonged responses to immunization with cognate peptide but were eliminated rapidly when exposed to HEL expressed systemically as a self antigen. In contrast, Fas- and FasL-defective T cells did not display exaggerated responses to immunization with HEL peptide, but did show increased expansion and survival in response to systemic self antigen and were able to activate anti-HEL (self) antibody-forming cells. Thus, Bcl-2 and Fas play different roles in the regulation of T cell responses to antigen in vivo and in self tolerance.
Chronic Obstruction of the Superior Vena Cava due to Histoplasmosis
Authors: ROBERT J. MARSHALL, ALPHONSE C. EDMUNDOWICZ, CHARLES E. ANDREWS
Journal: Circulation (1964)

Selective angiography and indicator-dilution curves were employed to illustrate the fuctional anatomy of the collateral circulation in two patients with chronic obstruction of the superior vena cava. In both, clinical and laboratory evidence favored an etiologic diagnosis of histoplasmosis. In case 1, the transit time via the main collateral venous pathway, which comprised the left superior intercostal, accessory hemiazygos and azygos veins, was found to be a little greater than 25 seconds. In case 2, the superior vena caval obstruction was incomplete, but there was an associated severe narrowing of the right pulmonary artery. Distortion of the indicator-dilution curves provided evidence for an increased bronchopulmonary anastomotic circulation to the right lung. These observations illustrate how radiographic and hemodynamic technics may usefully be combined to assess the effects of acquired diseases of the major blood vessels.
Race Differences in Long-Term Diabetes Management in an HMO
Authors: Alyce S. Adams, Fang Zhang, Connie Mah Trinacty, Richard W. Grant, Ken Kleinman, James B. Meigs, Dennis Ross-Degnan
Journal: Diabetes Care (2006)

We read Dr. Hart’s (1) response to our article with great interest. The issue of racial differences in the presence of variant hemoglobins that may affect HbA1c (A1C) test results is certainly an important one. Ours (2) was a retrospective analysis using electronic medical record data that did not contain information on either the presence of sickle hemoglobin or the results of …
Shujja-Ud-Din
Authors: N S Palta
Journal: BMJ (2007)

Shujja-Ud-Din was born in 1933 in Lahore, Pakistan. He came from a family of professionals and civil servants. His father was a qualified accountant in the Indian Audit Service. In 1947, on the partition of India, his family moved to Karachi, Pakistan, where he obtained his secondary and medical education.

Shujja obtained his undergraduate medical training at Dow Medical College, Karachi. He graduated in 1956 and completed his junior house physician posts in general medicine and neurology at Jinnah Post Graduate Medical Centre, Karachi.

In 1959 Shujja emigrated to the United Kingdom to further enhance his knowledge of medicine. He worked …
Semiquantitative assessment of hirsutism in Dutch women
Authors: J. DKRKSEN, A.J. MOOLENAAR, A.P. SETERS, D.F.M. KOCK
Journal: British Journal of Dermatology (1993)

Many doctors frequently encounter hirsute patients. Quantification of hair growth may be useful for diagnosis and follow-up. To establish the reference range for distribution and density of hair in females, and to determine the regions yielding the best discrimination between normal and hirsute women, we studied the distribution and density of terminal hair on 12 body regions assessed on a scale of 0-4. Prospectively, 81 healthy female volunteers and 71 hirsute patients of child-bearing age and Dutch ancestry, who were not receiving medication, and who had not had a recent pregnancy were studied. The reference hair pattern was established for each body region, and the threshold value yielding the highest sensitivity and specificity to evaluate hirsutism was calculated. None of the women in the reference population displayed a score of more than 1 for chin, upper back, upper abdomen and upper arm, or more than 2 for upper lip, side-burns, chest, lower back, lower abdomen, thighs or forearm. The best discrimination between the reference and hirsute populations was obtained with the sum of the scores for four regions: upper lip, chin, lower abdomen and thighs. Independent assessment of hair growth by two investigators revealed excellent agreement. We conclude that a score of more than 1 for chin, upper back, upper abdomen and upper arm, or more than 2 for upper lip, side-burns, chest, lower back, lower abdomen, thighs or forearm is abnormal for Dutch women, and that assessment of hair growth on the upper lip, chin, lower abdomen and thighs is the most suitable way to evaluate hirsutism.
A Course in Normal Histology.
Authors: Rudolf Krause, Philipp J. R. Schmahl
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hans Gerhart Kohler
Authors: Elizabeth Gray
Journal: BMJ (2005)

the distinguished UK transplant immunologist and Nobel laureate.She spent her life supporting her husband's career and working hard for causes she cared about and believed in-the global environment, population control, and family planning.She was one of a redoubtable group of women who had to combat the most extraordinarily hostile attitudes in the early days of family planning.She was fond of quoting a letter published in the Lancet in 1930, when she was 17, saying that the subject "was something that no decent man would handle with a pair of tongs."In 1954, when she was 31, she met Margaret Pyke, chairwoman of the Family Planning Association, and this started her considerable contribution to the movement.She became a member of the executive in 1960, and was chairwoman from 1968 to 1970.For two decades, from 1957 to 1976, she was joint editor of Family Planning (now Family Planning Today).
Breakfast and Crohn's disease--I.
Authors: P M Rawcliffe, S C Truelove
Journal: BMJ (1978)

holiday in Spain.Soon after arrival he had an infected spot beside his nose and within a few days began to feel unwell.Malaise and dyspnoea increased but he stayed in his hotel until the return flight.On arrival home he was confused and febrile but had no chest pain, cough, or sputum.He started taking ampicillin four days after returning home and was admitted to hospital on the next day, 2 June 1977.His fever of 38-5'C settled within three days but rose briefly to 38°C on days 7 and 11.He had an expiratory wheeze on both sides and crepitations on the right.Chest radiography (figure la) showed blotchy opacity on the right side.After five days of dry cough he produced green sputum, from which Klebsiella aerogenes and Candida albicans were grown (presumed to be superinfectants).Ampicillin, 500 mg 6-hourly, was continued until the 12th X *4 .. .| : Chest radiograph on second day of hospital admission (3 June 1977) (a) and four weeks later (b).Some shadowing and mediastinal spread persisted nine months later.
Proliferating Prizes: Large Financial Awards Go To Cancer Investigators
Authors: C. Vanchieri
Journal: JNCI Journal of the National Cancer Institute (1990)

Proliferating Prizes: Large Financial Awards Go To Cancer Investigators Get access Cori Vanchieri Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 9, 2 May 1990, Pages 733–734, https://doi.org/10.1093/jnci/82.9.733 Published: 02 May 1990
Mechanisms of stimulation of interleukin-1 beta and tumor necrosis factor-alpha by Mycobacterium tuberculosis components.
Authors: Y Zhang, M Doerfler, T C Lee, B Guillemin, W N Rom
Journal: Journal of Clinical Investigation (1993)

The granulomatous immune response in tuberculosis is characterized by delayed hypersensitivity and is mediated by various cytokines released by the stimulated mononuclear phagocytes, including tumor necrosis factor-alpha (TNF alpha) and IL-1 beta. We have demonstrated that Mycobacterium tuberculosis cell wall component lipoarabinomannan (LAM), mycobacterial heat shock protein-65 kD, and M. tuberculosis culture filtrate, devoid of LPS as assessed by the Amebocyte Lysate assay, stimulate the production of TNF alpha and IL-1 beta proteins and mRNA from mononuclear phagocytes (THP-1 cells). The effect of LAM on the release of these cytokines was specific, as only LAM stimulation was inhibited by anti-LAM monoclonal antibody. Interestingly, we found that LAM and Gram-negative bacterial cell wall-associated endotoxin LPS may share a similar mechanism in their stimulatory action as demonstrated by inhibition of TNF alpha and IL-1 beta release by monoclonal antibodies to CD14. Anti-CD14 monoclonal antibody MY4 inhibited both TNF alpha and IL-1 beta release with LAM and LPS but no effect was observed with other mycobacterial proteins. An isotype antibody control did not inhibit release of cytokines under the same experimental conditions. M. tuberculosis and its components upregulated IL-1 beta and TNF alpha mRNAs in THP-1 cells. Nuclear run-on assay for IL-1 beta demonstrated that LAM increased the transcription rate. The induction of IL-1 beta was regulated at the transcriptional level, in which these stimuli acted through cis-acting element(s) on the 5' flanking region of the IL-1 beta genomic DNA. M. tuberculosis cell wall component LAM acts similarly to LPS in activating mononuclear phagocyte cytokine TNF alpha and IL-1 beta release through CD14 and synthesis at the transcriptional level; both cytokines are key participants in the host immune response to tuberculosis.
Rupture of an Aortic Aneurysm into the Pulmonary Artery
Authors: CURTIS H. CARTER, WILLIAM N. AGOSTAS, V. P. SYDENSTRICKER
Journal: Circulation (1952)

A case report of rupture of an aortic aneurysm with antemortem diagnosis and a brief review of the common clinical findings in this syndrome are presented. The case reported was studied by cardiac catheterization which, it is felt, confirmed the clinical diagnosis. Postmortem findings are given and a drawing and photograph of the specimen is shown.
Laparoscopic-assisted percutaneous endoscopic gastrostomy - rendez-vous PEG - in infants, children and adolescents
Authors: H. Köhler, S. Razeghi, N. Spychalski, R. Behrens, R. Carbon
Journal: Endoscopy (2007)

In children with insufficient oral intake, the percutaneous endoscopic gastrostomy (PEG) has become the preferred method for enteral feeding [1] [2]. However, percutaneous puncture of the stomach may not be safe because of unfavorable anatomy. Major puncture-related complications, such as failed attempts, gastrocolocutaneous fistula, and massive hemorrhage, were seen in 9 % of all children who underwent PEG [3]. In order to avoid these complications we use a combined laparoscopic-assisted endoscopic (rendez-vous) approach in selected patients.
HIV Spreading in Middle East, North Africa Among People Who Inject Drugs
Authors: M. J. Friedrich
Journal: JAMA (2014)

In the past 10 years, HIV epidemics have begun to emerge among people who inject drugs in several countries in the Middle East and North Africa, reports an international group of researchers (Mumtaz GR et al. PLoS Med. 2014;11[6]:e1001663).
Thrombolytic therapy of acute pulmonary embolism: Current status and future potential
Authors: Samuel Z. Goldhaber, Michael F. Meyerovitz, John E. Markis, Ducksoo Kim, Craig M. Kessler, G.V.R.K. Sharma, Douglas E. Vaughan, Andrew P. Selwyn, Douglas L. Dawley, Joseph Loscalzo, Arthur A. Sasahara, Elliott B. Grossbard, Eugene Braunwald
Journal: Journal of the American College of Cardiology (1987)
The Biochemical Basis of Neuropharmacology
Authors: Frank J. Ayd
Journal: JAMA (1974)

This well-printed, easy-to-read book is based on a course given by the authors for undergraduate seniors, and graduate and medical students at Yale. Now that I have read it, I envy those privileged to take the course. If the authors lectured as clearly as they write, then they imparted a tremendous amount of information on certain aspects of the cellular foundations of neuropharmacology and the biochemistry of the central nervous system, with special emphasis on the neurotransmitters. In this second edition, the chapters have been up-dated with new information, so much so that there are now two chapters on the catecholamines because of coverage of recent findings on dopamine. New material on the prostaglandins, cyclic adenosine monophosphate (AMP), and the cholinergic receptor also has been added. Finally, more attention is given to drugs and to neurological diseases. At the end of each chapter, there is an excellent listing of carefully
Selective Primary Health Care
Authors: Julia A. Walsh, Kenneth S. Warren
Journal: New England Journal of Medicine (1979)

Priorities among the infectious diseases affecting the three billion people in the less developed world have been based on prevalence, morbidity, mortality and feasibility of control. With these priorities in mind a program of selective primary health care is compared with other approaches and suggested as the most cost-effective form of medical intervention in the least developed countries. A flexible program delivered by either fixed or mobile units might include measles and diphtheria-pertussis-tetanus vaccination, treatment for febrile malaria and oral rehydration for diarrhea in children, and tetanus toxoid and encouragement of breast feeding in mothers. Other interventions might be added on the basis of regional needs and new developments. For major diseases for which control measures are inadequate, research is an inexpensive approach on the basis of cost per infected person per year.For major diseases for which control measures are inadequate, research is an inexpensive approach on the basis of cost per infected person per year. Priorities among the infectious diseases affecting the 3 billion people in the less developed world have been based on prevalence, morbidity, mortality and feasibility of control. With these priorities in mind, a program of selective primary health care is compared with other approaches and suggested as the most cost-effective form of medical intervention in the least developed countries. A flexible program delivered by either fixed or mobile units might include measles and diptheria-pertussis-tetanus vaccination, treatment for febrile malaria and oral rehydration for diarrhea in children, and tetanus toxoid and encouragement of breast feeding in mothers. Other interventions might be added on the basis of regional needs and new developments. Aiming services at the most important diseases is the only rational approach to absolute proverty and unsanitary conditions. The goal is to help the greatest number of people in the cost effective method possible.
Association of Long-Term Exposure to Traffic-Related Air Pollution with Blood Pressure and Hypertension in an Adult Population–Based Cohort in Spain (the REGICOR Study)
Authors: Maria Foraster, Xavier Basagaña, Inmaculada Aguilera, Marcela Rivera, David Agis, Laura Bouso, Alexandre Deltell, Jaume Marrugat, Rafel Ramos, Jordi Sunyer, Joan Vila, Roberto Elosua, Nino Künzli
Journal: Environmental Health Perspectives (2014)

Long-term exposure to traffic-related air pollution may increase blood pressure (BP) and induce hypertension. However, evidence supporting these associations is limited, and they may be confounded by exposure to traffic noise and biased due to inappropriate control for use of BP-lowering medications.We evaluated the associations of long-term traffic-related air pollution with BP and prevalent hypertension, adjusting for transportation noise and assessing different methodologies to control for BP-lowering medications.We measured systolic (SBP) and diastolic BP (DBP) at baseline (years 2003-2005) in 3,700 participants, 35-83 years of age, from a population-based cohort in Spain. We estimated home outdoor annual average concentrations of nitrogen dioxide (NO2) with a land-use regression model. We used multivariate linear and logistic regression.A 10-μg/m3 increase in NO2 levels was associated with 1.34 mmHg (95% CI: 0.14, 2.55) higher SBP in nonmedicated individuals, after adjusting for transportation noise. Results were similar in the entire population after adjusting for medication, as commonly done, but weaker when other methods were used to account for medication use. For example, when 10 mmHg were added to the measured SBP levels of medicated participants, the association was β = 0.78 (95% CI: -0.43, 2.00). NO2 was not associated with hypertension. Associations of NO2 with SBP and DBP were stronger in participants with cardiovascular disease, and the association with SBP was stronger in those exposed to high traffic density and traffic noise levels ≥ 55 dB(A).We observed a positive association between long-term exposure to NO2 and SBP, after adjustment for transportation noise, which was sensitive to the methodology used to account for medication.
Blast injury of the lungs due to lightning.
Authors: A M Moulson
Journal: BMJ (1984)

Une observation rare: un malade de 18 ans, foudroye, survit a la partie «electrocution» mais conserve des contusions pulmonaires bilaterales etendues et une perforation du tympan. Traitement efficace par oxygene, benzylpenicilline et 4 jours de soins
Prostate Cancer — The Therapeutic Challenge of Locally Advanced Disease
Authors: John C. Blasko, Paul H. Lange
Journal: New England Journal of Medicine (1997)

The treatment of localized prostate cancer is a matter of considerable controversy. For decades experts vigorously debated the relative merits of radical prostatectomy and external-beam radiotherapy. During those years the proportion of patients who received radiotherapy remained high, because of the complications of surgery and the older age of the patients, and because most physicians believed that external-beam radiotherapy was the only cure for disease that had spread outside the prostate (i.e., stage T3 or T4).In the past decade, however, the proportion of patients treated with radiation changed dramatically. Because of the widespread use of prostate-specific-antigen (PSA) testing for . . .
Current efforts and trends in the treatment of NASH
Authors: Vlad Ratziu, Zachary Goodman, Arun Sanyal
Journal: Journal of Hepatology (2015)

Of all the aspects of non-alcoholic fatty liver disease (NAFLD), the slowest advances have occurred in the therapeutic field. Thirty-five years after its formal description and after 15 years of intense scrutiny from researchers worldwide, there is still no approved drug for the treatment of non-alcoholic steatohepatits (NASH). In the meantime, progress in the understanding of pathophysiology, diagnosis – both invasive and non-invasive, epidemiology and even natural history have been substantial or, at times, spectacular. In contrast, hepatitis C virus (HCV) therapy underwent constant improvement and even before the great acceleration of the past few years, patients were already being offered approved therapies that were increasingly more efficient.What then explains such a slow pace of therapeutic advances in NASH, and will this change in the near future? Here we will review commonly-held myths that have diverted attention from therapy of NASH, obstacles that have slowed down industrial development of drugs for this indication, and recent achievements that will create better conditions for drug development programs. We will also briefly review current knowledge of non-pharmacological and pharmacological management in this early era of NASH therapies.
THE IRREGULARITIES IN THE ACTION OF STRYCHNIA
Authors: J. Roulston
Journal: BMJ (1856)

heMy of coagulated albumen, and in many itances they ow a tndency to split into minute fbrilb .It is evident, therefore, that on the recognition of these dat-, and the practical application of them, much error ay be avoided, and the absence or existence of catrct rendered more certain, not to speak of the assistance that