tbuckley/cabot-search huggingface dataset:
EFFECT OF ANTIBODY AND COMPLEMENT ON PERMEABILITY CONTROL IN ASCITES TUMOR CELLS AND ERYTHROCYTES
Authors: H. Green, P. Barrow, B. Goldberg
Journal: The Journal of Experimental Medicine (1959)

Rabbit antibody + complement alters the permeability properties of mouse Krebs ascites tumor cells and erythrocytes. When antibody + C' acts on ascites tumor cells in a low protein medium, intracellular K(+) is lost from the cells at a rate far greater than the normal leak rate. At the same time the cells lose amino acids and ribonucleotides and become fully permeable to the Na(+) of the medium. When antibody + C' acts in a low protein medium, the cells swell extensively and lose most of their macromolecules to the medium (hemoglobin from erythrocytes, protein and RNA from the ascites tumor cells). If the antibody + C' acts in a medium containing protein in sufficient concentration to balance the colloid osmotic pressure of the cells, the swelling is prevented; no macromolecules are then lost from the cells, but the loss of K(+) and entrance of Na(+) are not altered, and the loss of amino acids and ribonucleotides is only slightly affected. It therefore appears that the action of antibody + C' is to produce functional "holes" in the animal cell membrane which permit the equilibration of cations and small molecules between cell and medium. This leads to an increase in the osmotic pressure of the cell and a rapid influx of water. The cell membrane and its "holes" are thereby stretched, permitting macromolecules to escape from the cell.
Cblb is a major susceptibility gene for rat type 1 diabetes mellitus
Authors: Norihide Yokoi, Kajuro Komeda, He-Yao Wang, Hideki Yano, Kazuhiro Kitada, Yuka Saitoh, Yutaka Seino, Kazuki Yasuda, Tadao Serikawa, Susumu Seino
Journal: Nature Genetics (2002)
On Reporting Interferon Research
Authors: SIDNEY E. GROSSBERG
Journal: Annals of Internal Medicine (1981)

Editorials1 July 1981On Reporting Interferon ResearchSIDNEY E. GROSSBERG, M.D.SIDNEY E. GROSSBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-1-115 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRecent progress in interferon research has emphasized the importance of the use of interferon standard preparations and the proper reporting of results of interferon studies. With the availability of sufficient quantities of human interferons for clinical trials, the preparations have been shown effective in the treatment of hepatitis B, respiratory virus infections, varicella-zoster, and other herpesvirus infections and of certain human tumors. Findings of these trials and of the many ongoing experimental investigations underscore the need for accurate comparisons among laboratories of the materials studied and the results obtained. Such studies include application of recombinant DNA technology to produce numerous...References1. GROSSBERG S. Interferon standards: a memorandum. J Biol Stand. 1979;7:383-95. CrossrefMedlineGoogle Scholar2. GROSSBERG S and GALASSO G. Problems in standardization: an Interferon Standards Committee report. In: SCHELLEKENS H, DEMAEYER E., eds. The Biology of the Interferon System. The Netherlands: Elsevier/North-Holland Biomedical Press; 1981. In press. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SIDNEY E. GROSSBERG, M.D.Affiliations: Department of Microbiology The Medical College of Wisconsin Milwaukee, Wisconsin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBibliographyAssay of InterferonsInhibition of chicken myogenesis invitro by partially purified interferon 1 July 1981Volume 95, Issue 1 Page: 115-116 Keywords Clinical trials DNA Hepatitis B Infectious hepatitis Interferons Research reporting guidelines Respiratory infections Respiratory system procedures Upper respiratory tract infections ePublished: 1 December 2008 Issue Published: 1 July 1981 PDF downloadLoading ...
Normal cerebral function with bilateral carotid occlusion.
Authors: P. F. Wrigley, P. Sheldon, C. W. Whitty
Journal: BMJ (1967)

Preliminary Communications MEDIALJOUN 93a new tumour-specific antigen or an isoantigen or even an antigenic constituent of a passenger virus.Whatever com- ponent of the tumour cell has provoked specific antibody forma- tion, such antibody can be employed as a homing carrier for cytoclastic chemicals.It is relevant that tumour-binding anti- body, also of uncertain nature, has been detected in cases of Burkitt's lymphoma (Klein, 1966); perhaps this would lend itself to immunoradiotherapy of a human tumour.Our results seem to be a promising beginning to the develop- ment of immunoradiotherapy of cancer.Experiments are in progress to determine the optimal timing of administration and doses of antibody and radioactivity required to cure established ascites tumour in mice.Other radioactive materials for con- jugation with the antisera should be investigated and the possi- bility of coupling antisera with nonradioactive cytotoxic chemicals which are effective at cell surfaces-for example, nitrogen mustard-should also be explored. SUMMARYAn antiserum to Ehrlich carcinoma in Balb/c mice, produced by immunizing rabbits, was found after appropriate absorptions to bind specifically to the tumour cells in vitro.Binding was confirmed by immunofluorescence and radioactive tracing; in the presence of complement the serum was also observed to be cyto- toxic to tumour cells in vitro.Mice inoculated with Ehrlich ascites cells which had been incubated with the gammaglobulin fraction of this antiserum coupled with 13 'I did not develop tumour, and have remained healthy for several weeks.In contrast, mice inoculated with tumour alone or with tumour incubated with noniodinated antiserum, with or without com- plement, or with iodinated nonimmune globulin invariably developed ascites tumour and died within 14 days of inoculation.ADDENDUM.-Sincegoing to press one of the four surviving mice, which received Ehrlich ascites tumour treated with the antitumour globulin coupled with 131I, died six weeks after inoculation.At necropsy no tumour was identified anywhere in the body, and death is attributed to extensive bronchopneumonia, the precise cause of which could not be ascertained; there was no histological evidence of significant radiation damage to abdominal organs or bone marrow.The other three surviving mice are still alive and free from any sign of tumour at ten weeks.
No Easy Answers for Physicians Caring for Pregnant Women With Depression
Authors: Bridget M. Kuehn
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Acute Migraine With Subcutaneous Sumatriptan
Authors: Roger K. Cady
Journal: JAMA (1991)

Sumatriptan succinate, a 5-HT1D receptor agonist, constricts human cranial arteries. Two parallel-group trials for treatment of acute migraines were conducted in the United States. Adult patients were randomized and given either 6 mg of sumatriptan succinate subcutaneously (n = 734) or placebo (n = 370). At 1 hour, sumatriptan was significantly more effective than placebo in reducing moderate or severe headache pain to mild or no pain (70% vs 22%), in completely relieving headaches (49% vs 9%), and in improving clinical disability (76% vs 34%). Sumatriptan also reduced nausea and photophobia significantly better than placebo. Patients with residual migraines received another injection; those who had originally received sumatriptan received either a second active injection (n = 187) or placebo (n = 178), while those who had received placebo received a second placebo injection (n = 335). Statistical evidence for benefit of second sumatriptan injection is absent. Adverse events associated with sumatriptan were tingling, dizziness, warm-hot sensations, and injection-site reactions. Sumatriptan is effective and well tolerated in patients with acute migraine.
About the use of the ACHIEVE paclitaxel eluting stent in treatment of restenotic lesions: A subanalysis of the 30-day safety data of DELIVER II
Authors: Antonio L. Bartorelli, Eberhard Grube, Didier Blanchard, Anthony Gershlick, Carlos Macaya, Sophie Henry, Christian Homsy
Journal: Journal of the American College of Cardiology (2003)
Money Isn't Everything
Authors: Emily Friedman
Journal: JAMA (1994)

WHETHER they take the form of managed competition, single-payer systems, regulated multipayer approaches, or expansion of Medicare and/or Medicaid, virtually all health care reform proposals share an underlying principle: that provision of coverage to the uninsured will ensure their access to care. (An exception is direct subsidy of hospital indigent care, which does not encourage structural change or make physician-based primary care available to the uninsured.) Unfortunately, the track record of American health care, especially in recent times, does not support the belief that coverage is equivalent to access. In the first place, all coverage is not created equal. For some theoretically insured groups, especially the Medicaid population, the availability of physician care is constrained,<sup>1-3</sup>and differences have been found in treatment patterns among patients with Medicare alone, Medicare and private supplemental coverage, and Medicare and Medicaid together.<sup>4</sup> Physicians' concerns about their financial viability following the introduction of
High-Density Lipoprotein Metabolism in Runners and Sedentary Men
Authors: Peter N. Herbert
Journal: JAMA (1984)

We studied the high-density lipoprotein (HDL) metabolism of five trained men who ran 16 km daily and five inactive men. Runners were leaner and their aerobic exercise capacity was much greater. The mean HDL cholesterol level was 65 mg/dL in the runners and 41 mg/dL in the controls. The lipid-rich HDL2 species accounted for a much higher proportion of the HDL in runners (49% v 29%). Tracer studies of radioiodinated autologous HDL demonstrated that runners did not produce more HDL protein but rather catabolized less. The mean biologic half-life of HDL proteins was 6.2 days in the runners compared with 3.8 days in the sedentary men. The activity of lipoprotein lipase was 80% higher in the postheparin plasma of the runners, whereas the activity of hepatic triglyceride hydrolase was 38% lower. Thus, the prolonged survival of plasma HDL proteins in runners may result from augmented lipid transfer to HDL by lipoprotein lipase or diminished HDL clearance by hepatic lipase.
Acute promyelocytic leukemia
Authors: Jerome Groopman, Leonard Ellman
Journal: American Journal of Hematology (1979)

Abstract Acute promyelocytic leukemia (APL) is characterized by proliferation of morphologically abnormal promyelocytes and a severe bleeding diathesis. The abnormal promyelocyte is characterized by abundant, large granules, many of which are spindle‐shaped. Electron microscopic appearance of the granules closely resembles that of Auer rods. The granules appear to possess tissue thromboplastin activity by both immunologic and clotting assays. Coagulation studies in APL are generally consistent with disseminated intravascular coagulation. Prolongation of the prothrombin time and elevation of fibrinogen degradation products are the tests that are most commonly abnormal. Although occasional reports indicate a favorable response of the coagulopathy to drugs that inhibit fibrinolysis, the use of prophylactic heparin appears to be the treatment of choice. The response rate of APL to chemotherapy regimens that contain an anthracycline is comparable to that of acute myelogenous leukemia. The recent description of the 15;17 chromosomal translocation which may be pathognomonic for APL is only the second example of a chromosomal marker of human neoplasia. Marked elevation of serum vitamin B 12 and B 12 binding proteins appears to be another characteristic feature of APL. An in vitro cell line of APL cells has been demonstrated to have the capacity to differentiate to functional polymorphonuclear leukocytes, but the cause for the maturation arrest is unknown.
Hewitt predicts 3% NHS growth for three years from 2008
Authors: Nicholas Timmins
Journal: BMJ (2007)

s health secretary, has said that some Muslim GPs may be divulging details of the sexual health of female Muslim patients to family members.Her comments drew an angry response from Muslim GPs, who said that her claims were based only on anecdotal evidence.However, Mrs Hewitt, who represents a constituency in Leicester with a large ethnic minority community, said, "I have had Muslim women give me chapter and verse on very distressing breaches of confidentiality by Muslim GPs."Some women patients in some Muslim communities are feeling they can't trust their own GP, who is from the same community and knows their extended family."If they go for particular situations, such as a sexual health problem or domestic violence, they fear they will share that information with other members of the family or community."Mrs Hewitt made her comments in an interview with the magazine for GPs Pulse (29 Mar, p 2).Vijoy Singh, chairman of the Leicestershire and Rutland local medical committee, which covers Ms Hewitt's constituency, said, "No GP would break confidentiality, because if they break it they are liable to be sued.She's out of touch."Mrs Hewitt cited a report published in November last year by the Muslim Women's Network, which was based on conversations with Muslim women throughout the country, as further evidence of her concerns.The report, She Who Disputes (www.thewnc.org.uk/pubs/shewhodisputesnov06.pdf),noted: "Health services were criticised for being insensitive and there was repeated concern that GPs from within the community could not be trusted to maintain patient confidentiality." Hewitt says some Muslim GPs breach confidentialityUK NEWS Safety agency prioritises better use of anticoagulants, p714 World NEWS drugs are as goo�� as ���� in stable coronary artery ��isease, stu��y s�o�s, p71� drugs are as goo�� as ���� in stable coronary artery ��isease, stu��y s�o�s, p71� , p71� bmj.com o�for�� ra��cliffe �ospitals tol�� to impro�e team�or� o�for�� ra��cliffe �ospitals tol�� to impro�e team�or�
Mosaicism for an Intragenic Deletion in a Boy with Mild Ornithine Transcarbamylase Deficiency
Authors: Anne Maddalena, Donna M. Sosnoski, Gerard T. Berry, Robert L. Nussbaum
Journal: New England Journal of Medicine (1988)

ORNITHINE TRANSCARBAMYLASE (OTC) is the X-linked enzyme that catalyzes the condensation of carbamyl phosphate and ornithine, forming citrulline in the urea cycle. Its activity in the mitochondria of liver cells is essential for the detoxification of ammonia, and its complete absence is usually lethal in the neonatal period.1 The majority of cases of nontransient neonatal hyperammonemia are due to inborn deficiencies of this enzyme. A milder form of OTC deficiency has a later onset and is characterized by episodes of hyperammonemia caused by infection or excessive protein intake. Even when protein intake is limited, male patients with partial OTC deficiency . . .
Water Metabolism after Cardiac Operations Involving a Gibbon-Type Pump-Oxygenator
Authors: GEORGE S. STURTZ, JOHN W. KIRKLIN, EDMUND C. BURKE, MARSCHELLE H. POWER
Journal: Circulation (1957)

Each of 21 patients was noted to have a low concentration of water in the serum immediately after whole-body perfusion. This indicated a loss of water either by the patient or the pump-oxygenator. Investigation suggested that the patient, and not the pump-oxygenator, was the source of water loss. Two of the 21 patients had a profuse, short-lived solute diuresis in the immediate postperfusion period. These phenomena are apparently benign and they require no specific treatment.
Healers and strangers. Immigrant attitudes toward the physician in America--a relationship in historical perspective
Authors: A. M. Kraut
Journal: JAMA (1990)

The current wave of immigration to the United States—mostly Asians and Latin Americans—may well be the largest in the 20th century. Many newcomers practice habits of health and hygiene deficient by American standards. Some prefer the shaman to the physician and traditional herb remedies to modern medical therapies. Physicians find themselves practicing at an invisible border separating them from their foreign-born patients, where differences of language and culture can lead to misunderstanding and frustration, impeding a physician's ability to gain cooperation with prescribed therapy. Similar issues faced physicians at the turn of the century. Newly arrived Italians, East European Jews, and Chinese were often ambivalent toward physicians and their therapies. Quacks further undermined the physician's credibility among immigrants. Today, some physicians try collaborating with shamans and herbalists to accommodate patients' cultural preferences. Respect for the customs and taboos of immigrant patients pays dividends in physician effectiveness and efficiency. (<i>JAMA</i>. 1990;263:1807-1811)
Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration
Authors: Yann Malato, Syed Naqvi, Nina Schürmann, Raymond Ng, Bruce Wang, Joan Zape, Mark A. Kay, Dirk Grimm, Holger Willenbring
Journal: Journal of Clinical Investigation (2011)

Recent evidence has contradicted the prevailing view that homeostasis and regeneration of the adult liver are mediated by self duplication of lineage-restricted hepatocytes and biliary epithelial cells. These new data suggest that liver progenitor cells do not function solely as a backup system in chronic liver injury; rather, they also produce hepatocytes after acute injury and are in fact the main source of new hepatocytes during normal hepatocyte turnover. In addition, other evidence suggests that hepatocytes are capable of lineage conversion, acting as precursors of biliary epithelial cells during biliary injury. To test these concepts, we generated a hepatocyte fate-tracing model based on timed and specific Cre recombinase expression and marker gene activation in all hepatocytes of adult Rosa26 reporter mice with an adenoassociated viral vector. We found that newly formed hepatocytes derived from preexisting hepatocytes in the normal liver and that liver progenitor cells contributed minimally to acute hepatocyte regeneration. Further, we found no evidence that biliary injury induced conversion of hepatocytes into biliary epithelial cells. These results therefore restore the previously prevailing paradigms of liver homeostasis and regeneration. In addition, our new vector system will be a valuable tool for timed, efficient, and specific loop out of floxed sequences in hepatocytes.
Nucleophosmin/B26 regulates PTEN through interaction with HAUSP in acute myeloid leukemia
Authors: N I Noguera, M S Song, M Divona, G Catalano, K L Calvo, F García, T Ottone, F Florenzano, I Faraoni, L Battistini, E Colombo, S Amadori, P P Pandolfi, F Lo-Coco
Journal: Leukemia (2012)
Diminished erythropoietin‐induced erythroid growth in patients with renal anemia is restored by recombinant human erythroid differentiation factor
Authors: Takashi Shimizu, Yoshifumi Kawano, Yoichi Takaue, Yasuhiro Kuroda
Journal: American Journal of Hematology (1994)

An examination of the in vitro sensitivity of marrow burst-forming units for erythroid (BFU-E) to various concentrations of human recombinant erythropoietin (rEpo) and interleukin-3 (IL-3, 20 ng/mL) in serum-deprived methylcellulose cultures revealed that cells obtained from patients with chronic renal failure showed a defective response to rEpo, particularly at lower concentrations. This poor response was not corrected by the addition of neutralizing antibodies to antitumor necrosis factor-alpha or antiinterleukin-1 alpha/beta. When purified CD34+ cells from these patients were tested for dose-dependent growth to rEpo, the curve resembled that of normal donors, indicating that there was an intrinsic defect in the patients' progenitor/accessory cell interactions. Using unseparated cells from the patients, we then tested whether the interaction between erythroid differentiation factor (EDF) and rEpo affected BFU-E growth. Although EDF, either alone or in combination with IL-3, did not affect the growth of BFU-E in the absence of rEpo, the reduced sensitivity to rEpo in the patients was brought closer to normal limits by the addition of 10 ng/mL EDF to the cultures. The present results may suggest the possibility that, in patients with renal anemia, concomitant administration of EDF may increase the therapeutic ratio of rEpo therapy by enhancing the sensitivity of progenitor cells to rEpo, thereby decreasing the therapeutic dose of costly rEpo.
Relationship between Physician Diagnosed Asthma, eNO, and Measures of Airway Hyperresponsivenes
Authors: F.A. Romero, D.L. Waggoner, D.T. Chiang, J. Clark, R.J. Hopp, R.G. Townley, T.B. Casale
Journal: Journal of Allergy and Clinical Immunology (2006)
Treatment of Bowel Infections of the Tropics
Authors: A. R. D. Adams
Journal: BMJ (1953)

A scheme offering unlimited chest x-ray facilities for general practitioners is described.Such a service could be provided in large towns if mass x-ray teams con- centrated entirely on examination of general practitioners' cases.The incidence of minor respiratory symptoms which are agreed by specialists to indicate the need for a chest x-ray film is so high in general practice that if the practi- tioner accepted the criteria and used the x-ray services available the clinics would be overburdened.Early pulmonary tuberculosis mimics the symptoms of commoner minor ailments.It is a wolf in sheep's clothing.These difficulties are well known to general practi- tioners, but the relatively narrow field of specialist experience has prevented the experts and the medical planners from being fully aware of them.In general practice pulmonary tuberculosis is often diagnosed only on a " time" basis, after elimination of other causes, as distinct from " instantaneous diag- nosis" by x-ray examination.It may be objected that by offering unlimited x-ray facilities to general practitioners the profligate use of film is encouraged.No evidence of dilution was found to suggest that those doctors who used the scheme inten- sively had a lower discovery rate than those who x-rayed less often.Tribute should be paid to the 183 general practitioners without whose enthusiastic participation the scheme could not have been started.We thank Dr. P. C. Anderson for advice and co-opera- ton in the interpretation of films.We are also much