The Effect of Green Tea on Simvastatin Tolerability
Authors: José Pablo Werba, Monica Giroli, Viviana Cavalca, Maria Cristina Nava, Elena Tremoli, Lorenzo Dal Bo
Journal: Annals of Internal Medicine (2008)

Letters19 August 2008The Effect of Green Tea on Simvastatin TolerabilityJosé Pablo Werba, MD, Monica Giroli, PhD, Viviana Cavalca, PhD, Maria Cristina Nava, MD, PhD, Elena Tremoli, PhD, and Lorenzo Dal Bo, PhDJosé Pablo Werba, MDFrom Cardiologico Monzino Center, Istituto Di Ricovero e Cura a Carattere Scientifico, Milan 20138, Italy, and Institute for Pharmacokinetic and Analytical Studies, Ligornetto 6853, Switzerland., Monica Giroli, PhDFrom Cardiologico Monzino Center, Istituto Di Ricovero e Cura a Carattere Scientifico, Milan 20138, Italy, and Institute for Pharmacokinetic and Analytical Studies, Ligornetto 6853, Switzerland., Viviana Cavalca, PhDFrom Cardiologico Monzino Center, Istituto Di Ricovero e Cura a Carattere Scientifico, Milan 20138, Italy, and Institute for Pharmacokinetic and Analytical Studies, Ligornetto 6853, Switzerland., Maria Cristina Nava, MD, PhDFrom Cardiologico Monzino Center, Istituto Di Ricovero e Cura a Carattere Scientifico, Milan 20138, Italy, and Institute for Pharmacokinetic and Analytical Studies, Ligornetto 6853, Switzerland., Elena Tremoli, PhDFrom Cardiologico Monzino Center, Istituto Di Ricovero e Cura a Carattere Scientifico, Milan 20138, Italy, and Institute for Pharmacokinetic and Analytical Studies, Ligornetto 6853, Switzerland., and Lorenzo Dal Bo, PhDFrom Cardiologico Monzino Center, Istituto Di Ricovero e Cura a Carattere Scientifico, Milan 20138, Italy, and Institute for Pharmacokinetic and Analytical Studies, Ligornetto 6853, Switzerland.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-4-200808190-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Many patients taking statins report muscle pain, which affects the patients' quality of life and adherence to treatment. Muscle effects of statins may be induced by interaction not only with other drugs but also with components of particular foods, such as grapefruit juice, which augment statin bioavailability (1).Objective: To report a case of statin muscle intolerance that was probably triggered by consumption of green tea.Case Report: A 61-year-old man had a history of primary hypercholesterolemia identified at age 50 years, and treatment with different statins was unsuccessful because of early muscle intolerance. He reported a family history ...References1. Lilja JJ, Neuvonen M, Neuvonen PJ. Effects of regular consumption of grapefruit juice on the pharmacokinetics of simvastatin. Br J Clin Pharmacol. 2004;58:56-60. [PMID: 15206993] CrossrefMedlineGoogle Scholar2. Donovan JL, Chavin KD, Devane CL, Taylor RM, Wang JS, Ruan Y, et al. Green tea (Camellia sinensis) extract does not alter cytochrome p450 3A4 or 2D6 activity in healthy volunteers. Drug Metab Dispos. 2004;32:906-8. [PMID: 15319329] CrossrefMedlineGoogle Scholar3. Chow HH, Hakim IA, Vining DR, Crowell JA, Cordova CA, Chew WM, et al. Effects of repeated green tea catechin administration on human cytochrome P450 activity. Cancer Epidemiol Biomarkers Prev. 2006;15:2473-6. [PMID: 17164372] CrossrefMedlineGoogle Scholar4. Kuriyama S, Shimazu T, Ohmori K, Kikuchi N, Nakaya N, Nishino Y, et al. Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study. JAMA. 2006;296:1255-65. [PMID: 16968850] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Cardiologico Monzino Center, Istituto Di Ricovero e Cura a Carattere Scientifico, Milan 20138, Italy, and Institute for Pharmacokinetic and Analytical Studies, Ligornetto 6853, Switzerland.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCurrent perspectives in herbal and conventional drug interactions based on clinical manifestationsCurrent View on Green Tea Catechins Formulations, Their Interactions with Selected Drugs, and Prospective Applications for Various Health ConditionsInteractions between nutraceuticals/nutrients and nutrients and therapeutic drugsHerb-Drug Interactions: Focus on Adverse Drug Reactions and Pharmacovigilance of Herbal MedicinesPeptic Ulcer Disease: A Brief Review of Conventional Therapy and Herbal Treatment OptionsToxicology and Drug Interactions of NutraceuticalsUpdate of green tea interactions with cardiovascular drugs and putative mechanismsCritical evaluation of causality assessment of herb-drug interactions in patientsThe Other Face of the Moon: Side Effects, Interactions and Molecules of ConcernsEpigallocatechin-3-gallate decreases the transport and metabolism of simvastatin in ratsEffects of four traditional Chinese medicines on the pharmacokinetics of simvastatinAdverse effects of plant food supplements and botanical preparations: a systematic review with critical evaluation of causalityPotential Therapeutic Effects of Statins in Alzheimer's DiseaseEffects of Natural Products on Pharmacokinetics and Pharmacodynamics of DrugsPharmacokinetic and Pharmacodynamic Interaction of Functional Foods with MedicinesPotential herb–drug interactions for commonly used herbsEffects of Green Tea Catechins on Cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A Activities in Human Liver and Intestinal MicrosomesGreen Tea Extract Affects the Cytochrome P450 3A Activity and Pharmacokinetics of Simvastatin in RatsTheranostics meets traditional Chinese medicine: rational prediction of drug–herb interactionsInteractions between Herbs and Conventional Drugs: Overview of the Clinical DataCholesterol-independent neuroprotective and neurotoxic activities of statins: Perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disordersStrategies for Treating Abnormal Lipid Profiles with Drugs 19 August 2008Volume 149, Issue 4Page: 286-287KeywordsCholesterolCreatineEnzymesHypertensionLiverMusclesMyalgiaStatinsTea ePublished: 19 August 2008 Issue Published: 19 August 2008 CopyrightCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...