Isoenzymes of Creatine Phosphokinase and Diagnosis of Myocardial Infarction
Authors: ROBERT ROBERTS
Journal: Annals of Internal Medicine (1973)

Editorials1 November 1973Isoenzymes of Creatine Phosphokinase and Diagnosis of Myocardial InfarctionROBERT ROBERTS, M.D., BURTON E. SOBEL, M.D.ROBERT ROBERTS, M.D., BURTON E. SOBEL, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-5-741 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSerum creatine phosphokinase isoenzymes have become a focus of intensive investigation, abetted by the recent development of sensitive techniques. The isoenzymes are likely to become particularly useful in the assessment of acute myocardial infarction (1) for reasons perhaps best appreciated by considering both the virtues and the limitations of total serum creatine phosphokinase as a diagnostic criterion.Elevation of creatine phosphokinase was recognized to be a manifestation of acute myocardial infarction by Dreyfus and co-workers in 1960 (2). Subsequently, its specificity was disputed because assay methods varied among institutions and because available procedures were relatively insensitive or subject to influence...References1. GOLDBERGWINFIELD DD: Diagnostic accuracy of serum enzyme assays for myocardial infarction in a general hospital population. Br Heart J 34:597-604, 1972 CrossrefMedlineGoogle Scholar2. DREYFUSSCHAPIRARESNAIS JGJ: La créatinekinase sérique dans le diagnostic de l'infarctus myocardique. Rev Franc Etudes Clin Et Biol 5:386-387, 1960 MedlineGoogle Scholar3. PRESTONBATSAKISBRIERE JJR: Serum creatine phosphokinase: a clinical and laboratory evaluation. Am J Clin Pathol 44:71-76, 1965 CrossrefGoogle Scholar4. ROSALKI S: An improved procedure for serum creatine phosphokinase determination. J Lab Clin Med 69:696-705, 1967 MedlineGoogle Scholar5. SOBELSHELL BW: Serum enzyme determinations in the diagnosis and assessment of myocardial infarction. Circulation 45:471-482, 1972 CrossrefMedlineGoogle Scholar6. 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Am J Cardiol 29:817-820, 1972 CrossrefMedlineGoogle Scholar17. LATNERSKILLEN AA: Isoenzymes in Biology and Medicine. New York, Academic Press, 1968, p. 187 Google Scholar18. PERTPINTERIC JL: Quantitation of starch gel electrophoresis. Ann NY Acad Sci 121:310-320, 1964 CrossrefMedlineGoogle Scholar19. ROBERTSHENRYSOBEL RPB: Quantification of creatine phosphokinase (CPK) isozymes in serum (abstract). Am J Cardiol 31:154, 1973 CrossrefGoogle Scholar20. SOBELSHELLKLEIN BWM: An isoenzyme of creatine phosphokinase in mitochondria from rabbit myocardium. J Mol Cell Cardiol 4:367-380, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT ROBERTS, M.D.; BURTON E. SOBEL, M.D.Affiliations: Cardiovascular Division Washington University Barnes and Wohl Hospitals St. Louis, Missouri PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiagnosis of Acute Myocardial InfarctionDevelopment of optical biosensor technologies for cardiac troponin recognitionBiomarkers in acute myocardial injuryThe clinical significance of cardiac troponins in medical practiceDiagnosis of Acute Myocardial InfarctionCoronary Heart Disease Syndromes: Pathophysiology and Clinical RecognitionAcute Myocardial InfarctionUnstable Angina Pectoris and Non-Q-Wave Myocardial InfarctionAnatomie und Pathologie des Koronargefäßsystems, Physiologie und Pathophysiologie der Koronardurchlutung, Pathogenese der AtheroskleroseKlinik und Diagnostik der koronaren HerzkrankheitTherapie der stabilen und instabilen Angina pectorisAkuter MyokardinfarktEvaluación y tratamiento de los traumatismos cardíacosKoronare Herzkrankheit und HerzinfarktCardiac enzymesAcute myocardial infarction in chest pain patients with nondiagnostic ECGs: Serial CK-MB sampling in the emergency departmentEstimation of myocardial infarct size with ultrasonic tissue characterization.The asymptomatic patient with suspected myocardial contusionValue of creatine phosphokinase isoenzyme determinations in the diagnosis of myocardial contusionElevated creatine phosphokinase MB in a patient with neuroendocrine carcinoma of the colon—Evidence for a tumor markerTotal Creatine Kinase and Isoenzyme Fractions in Chronic Dialysis PatientsInfarct size—can it be measured or modified in humans?The Q-wave and non-Q wave myocardial infarction: Differences and similaritiesDiagnostic changes in plasma creatine kinase isoforms early after the onset of acute myocardial infarction.Kinetics of serum creatine kinase and creatine kinase-MB after intracoronary thrombolysisDiagnosis of Acute Myocardial InfarctionEvaluation of an immunoradiometric assay specific for the CK-MB isoenzyme for detection of acute myocardial infarctionUnstable angina with episodic ST segment elevation and minimal creatine kinase release culminating in extensive, recurrent infarctionMyocardial infarct extension: Prevalence, clinical significance, and problems in diagnosisThe antibody inhibition procedure for the determination of myocardial creatine kinase isoenzyme (CK-MB)The late prognostic value of acute scintigraphic measurement of myocardial infarction size.Improved procedures for purification of human and canine creatine kinase isoenzymesCase Report CK-MB Isoenzyme in Patients with PolymyositisEvidence that hospital care for acute myocardial infarction has not contributed to the decline in coronary mortality between 1973-1974 and 1978-1979.Cardiac enzymesEfforts to Limit the Size of Myocardial InfarctsROBERT E. 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Clinical studies in the coronary care unit.Specificity of elevated serum MB creatine phosphokinase activity in the diagnosis of acute myocardial infarctionClinical measurement of myocardial infarct size. Modification of a method for the estimation of total creatine phosphokinase release after myocardial infarction.The enzyme diagnosis of myocardial infarctionAssessing Myocardial Damage in Acute Infarcts 1 November 1973Volume 79, Issue 5Page: 741-743KeywordsAcute myocardial infarctionCreatineMyocardial infarctionSpecificity ePublished: 1 December 2008 Issue Published: 1 November 1973 PDF downloadLoading ...