tbuckley/cabot-search huggingface dataset:
Retinoid Receptor Expression and all- <i>trans</i> Retinoic Acid–Mediated Growth Inhibition in Vascular Smooth Muscle Cells
Authors: Joseph M. Miano, Stavros Topouzis, Mark W. Majesky, Eric N. Olson
Journal: Circulation (1996)

Retinoids have been used in the successful treatment of a variety of human hyperproliferative diseases. Their role in smooth muscle cell (SMC) growth control, however, has not been clearly established. The present study was designed to assess the retinoid receptor mRNA expression profile in SMCs and to determine whether retinoids exert a growth-inhibitory effect in these cells.Five of the six retinoid receptors were expressed in both cultured SMCs and aorta as determined by Northern blotting or reverse transcriptase-polymerase chain reaction. Receptor activity was demonstrated in SMCs with the use of a reporter assay with a retinoid receptor DNA binding sequence linked to a chloramphenicol acetyltransferase reporter gene. DNA synthesis and cell proliferation assays were performed to show that all-trans retinoic acid (atRA) antagonized platelet-derived growth factor-BB and serum-stimulated SMC growth. Growth inhibition was distal to early growth-signaling events because induction of c-fos, c-jun, and egr-1 mRNA was unaffected by atRA. However, with an activated protein-1-linked chloramphenicol acetyltransferase reporter, atRA was shown to inhibit the activity of activated protein-1-dependent transcription in a transient transfection assay.These results establish the presence of functional retinoid receptors in SMCs and document the growth-inhibitory action of atRA on these cells. Retinoid compounds, already in clinical use as antiproliferative agents for nonvascular indications, should be assessed further in in vivo models of intimal disease.
ENCEPHALOMYELITIS SIMULATING DIPHTHERITIC PARALYSIS
Authors: S. Wyard, N. Hobhouse
Journal: BMJ (1935)

523 closely allied contaminants from such a compound is difficult.Since, however, the hitherto known alkaloids of ergot are quantitatively indistinguishable from one another by these pharmacological tests, the above experiments differentiate ergometrine from all of them, including the recently described alkaloids ergoclavine and sensibamine, which have been examined in Sir Henry Dale's laboratory.A paper by Dr. Vartiainen, dealing with ergoclavine and sensibamine, is now in the Press.The identity of the action of ergoclavine with that of ergotoxine has already been reported by Kreitmair.3
Impact Monitoring of the National Scale Up of Zinc Treatment for Childhood Diarrhea in Bangladesh: Repeat Ecologic Surveys
Authors: Charles P. Larson, Unnati Rani Saha, Hazera Nazrul
Journal: PLoS Medicine (2009)

Zinc treatment of childhood diarrhea has the potential to save 400,000 under-five lives per year in lesser developed countries. In 2004 the World Health Organization (WHO)/UNICEF revised their clinical management of childhood diarrhea guidelines to include zinc. The aim of this study was to monitor the impact of the first national campaign to scale up zinc treatment of childhood diarrhea in Bangladesh.
PREDISPOSITION TO FAMILIAL OSTEOARTHROSIS LINKED TO TYPE II COLLAGEN GENE
Authors: Aarno Palotie, Jürg Ott, Kati Elima, Kathryn Cheah, Pirjo Väisänen, Lasse Ryhänen, Miikka Vikkula, Eero Vuorio, Leena Peltonen
Journal: The Lancet (1989)
Strategies for Greener Hospital Operating Rooms
Authors: Carol Potera
Journal: Environmental Health Perspectives (2012)

Forum C8 Phased Out of Food WrappersIn July 2012 the U.S. FDA released a statement that manufacturers had voluntarily ceased selling agents containing the compound C8 for food-contact use the prior summer. 1 At that time, manufacturers had predicted stocks of the agents and packaging containing them would be depleted within a year.C8, or perfluorooctanoic acid, was used to keep oil and grease from seeping through food packaging.It is persistent in the environment and has been linked with testicular and kidney cancers and pregnancyinduced hypertension. 2 The compound is still used in products such as cookware and clothing. Where's the Cleanest Beach?In June 2012 the Natural Resources Defense Council released its annual Testing the Waters report on water quality at U.S. ocean and Great Lakes beaches. 3Certain beaches in Alabama, California, Delaware, Maryland, Minnesota, New Hampshire, and Texas have exceptionally low contamination rates and strong testing and safety practices, earning them the report's five-star rating.But the past two years had the second and third highest numbers of beach closures and advisories in the past two decades, with the majority a result of contamination with human or animal waste.The report cites measures to reduce stormwater runoff and sewage spills as top priorities for reducing beach closures and illnesses.
Lysophosphatidylcholine Increases Expression of Heparin-Binding Epidermal Growth Factor–Like Growth Factor in Human T Lymphocytes
Authors: Eiichiro Nishi, Noriaki Kume, Hiroshi Ochi, Hideaki Moriwaki, Yoshio Wakatsuki, Shigeki Higashiyama, Naoyuki Taniguchi, Toru Kita
Journal: Circulation Research (1997)

Abstract Atherosclerotic lesions contain substantial numbers of activated T lymphocytes in addition to monocytes/macrophages. T cell–derived cytokines and growth factors may play a role in atherogenesis; however, stimuli responsible for T-cell activation in atherogenesis have not been fully elucidated. In this study, we provide evidence that lysophosphatidylcholine (lyso-PC), a polar phospholipid component increased in atherogenic lipoproteins and atherosclerotic lesions, can upregulate gene expression and secretion of heparin-binding epidermal growth factor–like growth factor (HB-EGF) in cultured T lymphocytes isolated from human peripheral blood. Effects of lyso-PC on T lymphocytes appear to be selective and specific, since lyso-PC also increases interleukin (IL)-2 receptor expression but does not affect mRNA levels for IL-2 or IL-4. Lyso-PC–induced upregulation of HB-EGF and IL-2 receptor mRNA in peripheral T cells is mostly dependent on exogenous IL-2 in conditioned medium. The effect of lyso-PC on HB-EGF induction was more potent in CD4 + cells than in CD8 + cells, although lyso-PC increases IL-2 receptor expression dramatically in both CD4 + cells and CD8 + cells. Lyso-PC similarly increased HB-EGF expression in Jurkat cells, a cell line for human CD4 + T lymphocytes. These results in vitro suggest that lyso-PC may be an important stimulus for T cells in atherogenesis in vivo to upregulate HB-EGF and that T cell–derived smooth muscle growth factors may modulate atherosclerotic progression.
Clinical Comparison of Barbiturates as Hypnotics
Authors: T. W. Parsons
Journal: BMJ (1963)

MEDICAL JOUR~NALappears to be a highly important factor, as do other post- operative causes of increased intra-abdominal pressure such as vomiting, distension, and ascites.Incisions in the upper abdomen, and vertical incisions, carry a high risk of bursting.There is no evidence that the type of suture material used is of any importance.I should like to thank
Ancestors may provide clinical answers, say 'Darwinian' medical evolutionists
Authors: M. F. Goldsmith
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multiple regional differences in cellular properties that regulate repolarization and contraction in the right atrium of adult and newborn dogs.
Authors: M S Spach, P C Dolber, P A Anderson
Journal: Circulation Research (1989)

Recent studies of isolated cardiac myocytes have generated the need for detailed information about regional electrophysiological differences in the atrium. We measured the spatial distribution of action potentials in adult and newborn canine right atria. Multiple regional differences in action potential shape and duration were found. The multiple regional differences produced an overall simple pattern: the longest action potentials occurred in the area of the sinus node, and the action potential duration decreased with increasing distance from the sinus node area. To account for the overall pattern, we tested factors considered important in causing atrial action potential shape differences (e.g., electronic interactions). None of the factors tested accounted for the regional differences. We then found regional differences in the responses to pauses, which suggested that differences in the properties of individual cells accounted for the regional repolarization differences. If so, genetic regulation of the regional differences may produce the overall pattern on a developmental basis. Experiments in newborn atria showed that only in the upper crista was the spatial pattern similar to that of the adult; there was little variability in action potential shape and duration in the other areas. As a further test for associated regional differences in cell properties, we examined for differences in the isoform expression of troponin T (TnT1, TnT2, TnT3, and TnT4), a protein important in excitation-contraction coupling. In adults, the greatest proportion of TnT1 occurred in the area of the sinus node, and its proportion decreased with increasing distance from the sinus node area in association with a relative increase in the proportion of TnT2. In newborn atria the relative amount of TnT1 was greatest in the upper crista (similar to adult), but little difference was found in the distribution of the isoforms in the other regions. The correspondence between the regional differences in repolarization and in the expression of the troponin T isoforms in adult and newborn atria suggests that 1) cellular ionic mechanisms vary regionally to coordinate differences in action potential configuration with differences in cell properties that regulate contractility and 2) genetic expression of the systems that regulate repolarization and mechanical cellular properties are under similar developmental and regional control.
THE USE OF A SMALL MIRROR IN STUDYING THE APEX BEAT.
Authors: ROBERT L. PITFIELD
Journal: JAMA (1906)

Small mirrors have been affixed to galvanometers and the delicately moving parts of other instruments, and by means of beams of light thrown on the mirrors very fine movements may be detected and analyzed. A plate filled with mercury on which a beam of light is thrown, has been employed to detect the movements of the earth during earthquakes. By means of a small mirror pressed over the apex beat I have been able to demonstrate the movements of the apex of the heart in a case of Stokes-Adams disease. The movements were greatly amplified and it was easily possible with the beam of light to note the two kinds of impulses at the apex. In Stokes-Adams disease it has been found that the auricles and ventricles do not beat synchronously. A condition of heart block is brought about through disease of the bundle of His which conveys the contracting
Comparison of debrisoquine and guanethidine in treatment of hypertension.
Authors: F C Adi, C J Eze, A Anwunah
Journal: BMJ (1975)

A cross-over trail of debrisoquine and guanethidine in 32 patients showed that both drugs were equally effective in lowering both systolic and diastolic blood pressure. The degree to which they were tolerated by the patients, however, differed greatly. After three months on each drug 18 patients preferred debrisoquine, nine preferred guanethidine, and five showed no particular preference. At current prices the cost of daily treatment to the patient was cheaper with debrisoquine than with guanethidine.
Secretin receptors in the human liver: Expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma
Authors: Meike Körner, Gregory M. Hayes, Ruth Rehmann, Arthur Zimmermann, Arne Scholz, Bertram Wiedenmann, Laurence J. Miller, Jean Claude Reubi
Journal: Journal of Hepatology (2006)
TCT-419 Complete Percutaneous Approach For Arterial Access And Closure For Device Deployment In The Transfemoral Transcatheter Aortic Valve Replacement - A Comparison With Surgical Cut-down
Authors: Mamoo Nakamura, Tarun Chakravarty, Hasan Jilaihawi, Niraj Doctor, Suhail Dohad, Greg Fontana, Wen Cheng, Raj Makkar
Journal: Journal of the American College of Cardiology (2012)
Lifelong voluntary joint loading increases osteoarthritis in mice housing a deletion mutation in type II procollagen gene, and slightly also in non-transgenic mice
Authors: T Lapvetelainen
Journal: Annals of the Rheumatic Diseases (2002)

<b>Objectives:</b> To investigate the effects of voluntary running on the incidence and severity of osteoarthritis (OA) and associated changes in cartilage matrix and subchondral bone in a transgenic Del1 mouse model for OA. <b>Methods:</b> Del1 mice and their non-transgenic littermate controls were housed from the age of 5–6 weeks to 15 months in individual cages with running wheels. The running activity of each mouse was monitored for the entire 12 month period. Additional Del1 and control mice were housed in individual cages without running wheels. At the end of the experiment the severity of OA was evaluated by light microscopy, and the articular cartilage matrix changes by digital densitometry and quantitative polarised light microscopy. <b>Results:</b> Lifelong voluntary running increased the incidence and severity of OA significantly in Del1 mice (transgenic runners), and slightly also in non-transgenic runners. Severe OA changes increased from 39% in transgenic non-runners to 90% in transgenic runners (p=0.006) in lateral tibial condyles, and from 24% to 80% (p=0.013) in lateral femoral condyles, respectively. The proteoglycan content of articular cartilage was reduced in transgenic runners in comparison with transgenic non-runners (p=0.0167), but a similar effect was not seen in non-transgenic runners compared with non-transgenic non-runners. No attributable differences were seen in the collagen network of articular cartilage or in the subchondral bone between any of the groups. <b>Conclusion:</b> The Del1 mutation has earlier been shown to disturb the assembly of the cartilage collagen network and thereby increase the incidence and severity of OA with age. In this study, voluntary running was shown to increase further cartilage damage in the lateral compartments of the knee. This suggests that articular cartilage in Del1 mice is less resistant to physical loading than in control mice. Despite severe OA lesions in the knee joint at the age of 15 months, Del1 mice continued to run voluntarily 2–3 km every night.
Chimney Stove Intervention to Reduce Long-term Wood Smoke Exposure Lowers Blood Pressure among Guatemalan Women
Authors: John P. McCracken, Kirk R. Smith, Anaité Díaz, Murray A. Mittleman, Joel Schwartz
Journal: Environmental Health Perspectives (2007)

RESPIRE, a randomized trial of an improved cookstove, was conducted in Guatemala to assess health effects of long-term reductions in wood smoke exposure. Given the evidence that ambient particles increase blood pressure, we hypothesized that the intervention would lower blood pressure.TWO STUDY DESIGNS WERE USED: a) between-group comparisons based on randomized stove assignment, and b) before-and-after comparisons within subjects before and after they received improved stoves. From 2003 to 2005, we measured personal fine particle (particulate matter with aerodynamic diameter < 2.5 microm; PM(2.5)) exposures and systolic (SBP) and diastolic blood pressure (DBP) among women > 38 years of age from the chimney woodstove intervention group (49 subjects) and traditional open wood fire control group (71 subjects). Measures were repeated up to three occasions.Daily average PM(2.5) exposures were 264 and 102 microg/m(3) in the control and intervention groups, respectively. After adjusting for age, body mass index, an asset index, smoking, secondhand tobacco smoke, apparent temperature, season, day of week, time of day, and a random subject intercept, the improved stove intervention was associated with 3.7 mm Hg lower SBP [95% confidence interval (CI), -8.1 to 0.6] and 3.0 mm Hg lower DBP (95% CI, -5.7 to -0.4) compared with controls. In the second study design, among 55 control subjects measured both before and after receiving chimney stoves, similar associations were observed.The between-group comparisons provide evidence, particularly for DBP, that the chimney stove reduces blood pressure, and the before-and-after comparisons are consistent with this evidence.
The German situation
Authors: Ralph Beneke
Journal: British Journal of Sports Medicine (2000)

Over the past century, education in sports medicine and exercise physiology in Germany has undergone various modifications. Furthermore, the reunification of the country over the last decade has caused political and economic changes resulting in fundamental and continuing changes in education and in the professions of general doctors, clinically orientated specialists, and basic and applied scientists in the field of sports medicine and exercise physiology. Currently, doctors in Germany do not have the opportunity to specialise in sports medicine. However, the introduction of such professional training is continuously being discussed. Every fully trained doctor can acquire additional certification in sports medicine. This consists of a course of 120 lessons on theory and practice in sports medicine, including basics and special aspects such as children, top level sports, prevention of injury and rehabilitation, psychology, movement science, biomechanics, and pedagogics, plus 120 lessons on the theory and practice of …
Trusts need local negotiating committees
Authors: M. Goldman
Journal: BMJ (1992)

provincial clinic seeing around 4500 new cases a year.In two weeks 116 calls were made for results and 65 for advice (roughly 9000 annually).Most of these calls were dealt with by clerical and nursing staff, but to do so adequately they require experience and training.If telephone calls are to be used more their use should be included in routine statistics and the demand they make planned for.
Tracing the development of acute myeloid leukemia in CBL syndrome
Authors: Heiko Becker, Kenichi Yoshida, Nadja Blagitko-Dorfs, Rainer Claus, Milena Pantic, Mahmoud Abdelkarim, Christoph Niemöller, Christine Greil, Björn Hackanson, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Konstanze Döhner, Susanne Schnittger, Philipp Henneke, Charlotte M. Niemeyer, Christian Flotho, Dietmar Pfeifer, Seishi Ogawa, Michael Lübbert
Journal: Blood (2014)
Bacterial Endocarditis Due to Moraxella New Species I
Authors: Craig E. Christensen, George C. Emmanouilides
Journal: New England Journal of Medicine (1967)

ALTHOUGH endocarditis due to gram-negative pleomorphic organisms is being increasingly recognized, to our knowledge there are no clinical reports of infection with one such organism, Moraxella new species I. In the following case of bacterial endocarditis in a four-year-old boy with ventricular septal defect this organism was isolated from the blood.Case ReportA 4-year-old boy had been followed in the Pediatric Clinic at Harbor General Hospital with the clinical diagnosis of a small ventricular septal defect. On September 23, 1964, he was admitted to the hospital with a 2-week history of malaise, pallor, irritability, anorexia, occasional vomiting and . . .
Medical aid groups treat hundreds of mass rape victims in eastern Congo
Authors: J. Zarocostas
Journal: BMJ (2010)

International medical and humanitarian groups are providing emergency medical treatment and psychosocial support to hundreds of women, children, and men, mass raped by rebel soldiers in July and August in the war ravaged eastern areas of the Democratic Republic of the Congo.

The aid groups, many of which are provided with support by the World Health Organization and Unicef, include the US based International Medical Corps, Save the Children, Merlin, Heal Africa, Care International, and Oxfam.

Margaret Aguirre, director of global communications for International Medical Corps, told the BMJ that …
AER 003, a PEGylated IL-4/IL-13 Antagonist, Significantly Reduces Allergen-Induced Airway Hyperresponsiveness (AHR)
Authors: A. Tomkinson, L. Stevens, M. Morton, A. Bowden, T. Wong, D. Boisvert, K. Delaria, E. Burmeister Getz
Journal: Journal of Allergy and Clinical Immunology (2010)
Neurocardiogenic (Vasodepressor) Syncope
Authors: Kim Eagle, Stefan Osswald, Thomas G. Trouton
Journal: New England Journal of Medicine (1993)

Figure 1. Neurocardiogenic (Vasodepressor) Syncope. A 72-year-old woman with breast cancer that had metastasized to the glossopharyngeal region had recurrent episodes of sudden lightheadedness, diaphoresis, and syncope. A dual-chamber pacemaker was implanted, but syncope recurred, always preceded by severe neck pain. During the tilt-table test with the pacemaker inactivated, the results of which are shown here, the patient's usual symptoms developed. She lost consciousness and had a seizure, but regained consciousness immediately after she was returned to the supine position. The study shows a profound vasodepressor reaction with minimal slowing of the sinus rhythm. Treatment with disopyramide (150 mg three . . .
Use of chronically-implanted ultrasonic crystals in the intact heart of the cat
Authors: T. A. HURLBUT, F. SCALES, L. M. BUJA, J. T. WILLERSON
Journal: Cardiovascular Research (1978)

Journal Article Use of chronically-implanted ultrasonic crystals in the intact heart of the cat Get access TERRY A. HURLBUT, III, TERRY A. HURLBUT, III From the Departments of Internal Medicine (Cardiac Unit) and Pathology at The University of Texas Health Science Center, Dallas, Texas Search for other works by this author on: Oxford Academic PubMed Google Scholar FLOYD SCALES, FLOYD SCALES From the Departments of Internal Medicine (Cardiac Unit) and Pathology at The University of Texas Health Science Center, Dallas, Texas Search for other works by this author on: Oxford Academic PubMed Google Scholar L. MAXIMILIAN BUJA, L. MAXIMILIAN BUJA From the Departments of Internal Medicine (Cardiac Unit) and Pathology at The University of Texas Health Science Center, Dallas, Texas Search for other works by this author on: Oxford Academic PubMed Google Scholar JAMES T. WILLERSON JAMES T. WILLERSON 1 From the Departments of Internal Medicine (Cardiac Unit) and Pathology at The University of Texas Health Science Center, Dallas, Texas 1Dr Willerson is an Established Investigator of the American Heart Association. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 12, Issue 6, June 1978, Pages 387–390, https://doi.org/10.1093/cvr/12.6.387 Published: 01 June 1978