Cimetidine and Lidocaine
Authors: J. ROBERT POWELL
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 August 1983Cimetidine and LidocaineJ. ROBERT POWELL, PHARM. D.J. ROBERT POWELL, PHARM. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-2-279_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Knapp and associates (1) indicate Cimetidine causes lidocaine serum concentrations to rise 75% in patients receiving a lidocaine infusion. They report that this results in an increased incidence of lidocaine toxicity and suggest Cimetidine decreases lidocaine clearance by decreasing hepatic blood flow. There are several limitations to this study that do not allow me to accept these conclusions with confidence.Lidocaine serum concentrations are known to rise on chronic infusion due to a time-dependent decrease in lidocaine clearance of free drug and total drug in plasma, which may independently account for a 15% and 50% rise in...References1. KNAPPMAGUIREKEREN AWG. The cimetidine-lidocaine interaction. Ann Intern Med. 1983;98:174-7. LinkGoogle Scholar2. BARCHOWSKYSHANDSTARGELWAGNERROUTLEDGE ADWGP. On the role of α1-acid glycoprotein in lignocaine accumulation following myocardial infarction. Br J Clin Pharmacol. 1982;13:411-5. CrossrefMedlineGoogle Scholar3. ROUTLEDGESTARGELWAGNERSHAND PWGD. Increased alpha-1-acid glycoprotein and lidocaine disposition in myocardial infarction. Ann Intern Med. 1980;93:701-4. LinkGoogle Scholar4. FEELYWILKINSONWOOD JGA. Reduction of liver blood flow and propranolol metabolism by Cimetidine. N Engl J Med. 1981; 304:692-5. CrossrefMedlineGoogle Scholar5. PAWLICKTAGUETEPPERMANMILLERJACOBSON WLBTE. Histamine H1- and H2 - receptor vasodilation of canine intestinal circulation. Am J Physiol. 1977;233:E219-24. MedlineGoogle Scholar1. KNAPPMAGUIREKEREN AWG. The cimetidine-lidocaine interaction. Ann Intern Med. 1983;98:174-7. LinkGoogle Scholar2. COLLINSWORTHKALMANHARRISON KSD. The clinical pharmacology of lidocaine as an antiarrhythmic drug. Circulation 1974;50:1217-30. CrossrefMedlineGoogle Scholar3. GIANELLYVON DER GROEBANSPIVACKHARRISON RJAD. Effect of lidocaine on ventricular arrhythmias in patients with coronary heart disease. N Engl J Med. 1967;277:1215-9. CrossrefMedlineGoogle Scholar4. BARCHOWSKYSHARDSTARGELWAGNERROUTLEDGE ADWGP. On the role of α1-acid glycoprotein in lidocaine accumulation following myocardial infarction. Br J Clin Pharmacol. 1982;13:411-5. CrossrefMedlineGoogle Scholar5. ZITOREID RP. Lidocaine kinetics predicted by indocyanine green clearance. N Engl J Med. 1978;298:1160-3. CrossrefMedlineGoogle Scholar6. FEELYWILKINSONWOOD JGH. Reduction of liver blood flow and propranolol metabolism by Cimetidine. N Engl J Med. 1981;304:692-5. CrossrefMedlineGoogle Scholar7. CHARBONBROUWERSSALA GHA. Histamine H1 & H2 receptors in the gastrointestinal circulation. Naunyn Schmiedebergs Arch Pharmacol. 1980;312:123-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of North Carolina Chapel Hill, NC 27514 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBiologically Active Organofluorine CompoundsThe effect of oral cimetidine on total and unbound serum lidocaine concentrations in patients with suspected myocardial infarction 1 August 1983Volume 99, Issue 2Page: 279-279KeywordsAttentionBlood flowBlood plasmaDrugsToxicity Issue Published: 1 August 1983 PDF downloadLoading ...