tbuckley/cabot-search huggingface dataset:
Eustachian Valve Thrombosis
Authors: Javier Escota-Villanueva, Isaac Lacambra-Blasco, Carmen Gonzalvo
Journal: Circulation (2008)

A 61-year-old man who presented with syncope for several minutes recovered spontaneously.On admission, the patient was asymptomatic, and the initial physical examination was normal.The first complementary tests (ECG, blood laboratory, chest radiography, cerebral computed tomography, and pulmonary scintigraphy) showed no abnormalities.A transthoracic echocardiogram showed a worm-like mass in the right atrium not clearly attached to the heart wall.Unfractionated heparin was initiated with the initial suspicion of intracardiac thrombus.Thirty-six hours later, a transesophageal echocardiography revealed a 4ϫ8-mm mobile mass on the eustachian valve (Movie I), the size of which was decreased considerably with respect to the previous study after an intensive anticoagulation therapy.This finding supported the initial diagnosis of intracardiac thrombosis, and oral anticoagulation with warfarin was begun.After discharge (3 and 6 months later), 2 new transesophageal studies were made that provided evidence of the complete disappearance of the eustachian valve thrombus (Movies II and III).The eustachian valve in adult is an embryological remainder of the fetal venous sinus valve.This structure is located in the right atrium and is a common, not pathological, echocardiographic finding.It is known that in 4% to 18% of pulmonary embolisms, thrombi are discovered in the right side of the heart; however, their presence on the eustachian valve is very unusual.Only 3 cases have been reported with this finding: 2 patients in the context of pulmonary embolism and 1 who was asymptomatic.In the 3 cases, an aggressive treatment (fibrinolytic therapy or systemic anticoagulation) achieved complete thrombus lysis.
Inhibitory actions of loperamide on absorptive processes in rat small intestine.
Authors: J Hardcastle, P T Hardcastle, J Cookson
Journal: Gut (1986)

Mucosal loperamide caused a dose dependent reduction in the absorption of actively transported hexoses and amino acids, together with the associated rise in short circuit current. Na+ and fluid movement were also inhibited. Serosal application of the drug was without effect on these processes. The passive movement of fructose across the gut was not affected by loperamide which is therefore unlikely to act by reducing tissue permeability. In low Na+ conditions the inhibitory actions of loperamide on glycine absorption were reduced. Loperamide reduced basal Na+ transport although it did not affect the stimulation of Na+ absorption caused by mannose. Loperamide had no effect on the total ATPase activity nor on the Na+, K+-ATPase activity of mucosal homogenates. The effects of loperamide were not mimicked by morphine nor were they antagonised by naloxone and hence do not seem to involve an opiate receptor. It is concluded that loperamide exerts its inhibitory effects by an interaction with the Na+ sites of the nutrient carriers.
Retrovirus–mediated wild–type P53 gene transfer to tumors of patients with lung cancer.
Authors: J.A. Roth, D. Nguyen, D.D. Lawrence, B.L. Kemp, C.H. Carrasco, D.Z. Ferson, W.K. Hong, R. Komaki, J.J. Lee, J.C. Nesbitt, K.M.W. Pisters, J.B. Putnam, R. Schea, D.M. Shin, G.L. Walsh, M.M. Dolormente, C.-I. Han, F.D. Martin, N. Yen, K. Xu, L.C. Stephens, T.J. Mcdonnell, T. Mukhopadhyay, D. Cai
Journal: Nature Medicine (1996)
Effect of Intravesical Instillations on the Human Complement Factor H Related Protein (BTA &lt;i&gt;stat&lt;/i&gt;) Test
Authors: M.-P. Raitanen, P. Hellstr&ouml;m, T. Marttila, H. Korhonen, M. Talja, J. Ervasti, T.L.J. Tammela
Journal: European Urology (2001)
Forging Ahead — Embracing the “Reconciliation” Option for Reform
Authors: Henry J. Aaron
Journal: New England Journal of Medicine (2010)

The course of health care reform in 2009 resembled the silent movie series “The Perils of Pauline,” in which each episode began with a threat to the heroine's life but ended with her salvation. Despite repeated near-death experiences, reform legislation passed both houses of Congress. After so many obstacles had been surmounted, the remaining task of reconciling the House and Senate bills seemed doable.Then, a political earthquake hit. Republican Scott Brown won the Massachusetts senatorial seat that had been held for 47 years by the late Senator Edward M. Kennedy, thwarting the capacity of the remaining 57 Democrats and . . .
The Man with the Movie Camera
Authors: T. Delamothe
Journal: BMJ (1994)

Outside, its architectural style suggests late period Ceausescu. Inside, the former rules of East European states would have felt at home with its luxuries and obsessive secrecy. No wonder the locals refer to the building as the Kremlin or the People's Palace and talk in hushed tones of its fabled opulence.

Yet this is Quarry House, Leeds, built at a cost of [L]55m to house the NHS Management Executive and partly the Department of Social Security when it moved from London. It is tangible evidence of the new managerial ascendency. Here and Now took us on a guided tour of its interior, courtesy of cardiac surgeon Duncan Walker, who smuggled in a camera and a tape recorder.

But before our clandestine tour we …
Psychiatric needs must be considered
Authors: W. R. Jones, J. F. Morgan
Journal: BMJ (2010)

Increasing bariatric surgery for appropriate candidates could be cost effective and save the NHS and the wider community millions of pounds a year.1 However, such an increase may exacerbate the existing difficulties of obesity services in addressing the preoperative and postoperative psychiatric needs of patients having such surgery.

Many (50-80%) morbidly obese patients seeking bariatric surgery have …
Another Foetus Cries
Authors: J. Burton-Brown
Journal: BMJ (1947)

MBRITISHThirdly, the evidence from Brixton prison appears to support the alleged connexion between natural homosexuality and sexual perversion, which is the view put forward by Sir Norwood East and W. H. Hubert2 and Clifford Allen,4 and opposed by Havelock Ellis and others.J. A. Symonds (in an unpublished essay) admits that, although " a far larger proportion of mental disturbance and nervous hypersensitivity can he proved in Urnings than in normal men, in a vast majority of cases the Urning owing to present laws and social prejudices cannot, like other men, obtain a simple and easy satisfaction of his inborn sexual desires, which for him are as natural as swimming to a fish.It is this forcible suppression of an instinct so deeply rooted in his nature which originates the morbid symp- toms that may often be observed in the Urning."The same author attributes to homosexual fears *and guilt " at least half of the suicides of young men."Bernard Shaw has stated
Biotechnology and Medicine of the Future
Authors: Leroy Hood
Journal: JAMA (1988)

The practice of biology and medicine has been revolutionized during the past ten years by the advent of three biotechnologies--recombinant DNA techniques, the monoclonal antibody technology, and the development of microchemical instrumentation, machines that permit the rapid and effective synthesis and sequence analysis of proteins and genes. In this article, these powerful biotechnologies will be discussed, with particular emphasis on microchemical instrumentation, a major focus of my efforts for the past 15 years. I will also discuss two fundamental problems in modern medicine that are being explored in my laboratory using these techniques--genetic engineering of the nervous system and the mapping and sequencing of the human genome.
A case of multiple trichoepithelioma with an unusual appearance
Authors: A. Kanda, A. Gushi, T. Kanzaki
Journal: British Journal of Dermatology (2003)

Sir, Trichoepithelioma is a benign skin tumour related to the pilosebaceous apparatus. It predominantly occurs on the face as a solitary lesion or as multiple small papules.1 We report a patient with multiple trichoepithelioma who had giant nodules on her face; each nodule could be considered as a giant solitary trichoepithelioma (GST)2 which Czernobilsky reported as a rare type of trichoepithelioma. There have been several cases of GST in the past.2–7 However, our case is different from typical GST because of the multiple lesions and their location. A 42‐year‐old woman presented with dome‐shaped elastic soft nodules of 2·5‐cm diameter on her bilateral upper labial region, which caused no pain or irritation (Fig. 1a). Telangiectasia was also noted in these nodules. Similar but smaller nodules were found on her lower lip, forehead and bilateral eyebrow regions. The original lesion was a small solitary nodule on her upper lip which had occurred 7 years previously and had gradually spread to give this unusual appearance. Our patient had had systemic lupus erythematosus for 10 years but it was well controlled with prednisolone 10 mg daily. Otherwise, she had no relevant clinical history. None of her immediate family had skin tumours.
Thermal removal of pyrene contamination from soil: basic studies and environmental health implications.
Authors: H H Saito, V Bucalá, J B Howard, W A Peters
Journal: Environmental Health Perspectives (1998)

Effects of temperature (400-1000 degrees C) and rate of heating to 550 degrees C (100, 1000, 5000 degrees C/sec) on reduction of pyrene contamination in a Superfund-related soil and on yields of volatile products (tars, CO, CO2, methane, acetylene, ethylene) have been measured. Fifty (+/- 3)-milligram thin layers (less than or equal to 150 micron) of 63- to 125-micron soil particles, neat (i.e., without exogenous chemicals), or pretreated with 4.75 wt% of pyrene, were heated for about 1 to 6 sec, under 3 psig (pounds per in.(2) gauge) of helium in a 12-liter sealed chamber. Pyrene removal, defined as the difference in weight loss of neat versus contaminated soil, was virtually immune to heating rate but increased strongly with increasing temperature, approaching 100% at about 530 degrees C. However, for pyrenepolluted soil, excess soil weight loss and modified CO yields were observed above about 500 degrees C for a 1000 degrees C/sec heating rate. These observations suggest that soil chemical reactions with pyrene or pyrene decomposition products augment soil volatilization. Consequently at elevated temperatures, the difference in weight loss protocol may overestimate polycyclic aromatic hydrocarbon (PAH) removal from soil. Increasing heating rate caused yields of CO, CO(2), and acetylene from pyrene-polluted soil to pass through maxima. Heating neat or contaminated soil resulted in at least two gaseous products of particular environmental interest:acetylene, a precursor to PAH in thermal synthesis, and CO, a toxin to human hemoglobin.
Two intracoronary doses of basic fibroblast growth factor enhance collateral blood flow in dogs
Authors: Shamini Rajanayagam, Matie Shou, Venugopal Thirumurti, Everett Hodge, Daisy F. Lazarous, Arshed A. Quyyumi, Stephen E. Epstein, Ellis F. Unger
Journal: Journal of the American College of Cardiology (1996)
NICE rules out NHS prescription of fingolimod for multiple sclerosis
Authors: D. Cohen
Journal: BMJ (2011)

<h3>BACKGROUND AND PURPOSE:</h3> Carotid near-occlusion has been subclassified into near-occlusion with and without collapse. We aimed to compare the technical success and perioperative complication rates of carotid artery stent placement with special attention to these subtypes to see whether there is a clinical relevance of this subclassification. <h3>MATERIALS AND METHODS:</h3> From January 2014 to January 2018, we retrospectively evaluated all patients with atherosclerotic extracranial carotid stenosis treated by carotid artery stent placement. Patients with near-occlusion were identified based on DSA findings. Patient characteristics, the presence of criteria for near-occlusion and collapse, arterial diameters, technical success rate, and perioperative (≤30 days) complications were analyzed. <h3>RESULTS:</h3> We identified 59 near-occlusions in 58 (46 men, 11 with collapse) patients. Forty-one patients (70.7%) were symptomatic. Technical success rate was 98.3% (58 of 59 procedures). In 1 case of near-occlusion with collapse, we were not able to pass through the stenosis. Compared with patients without collapse (4.2% of 48 cases), those with collapse (30% of 10 stented patients) had significantly higher rates of postintervention hyperperfusion syndrome (<i>P</i> = .032). In the whole cohort, the permanent morbidity and mortality rate was 3.4% (1.7% permanent morbidity and 1.7% mortality). For asymptomatic and symptomatic near-occlusion groups, the rates were 0% and 4.9%, respectively. The composite risk of stroke, death, and myocardial infarction was similar between the groups with and without collapse (<i>P</i> = .682). Rate of hyperperfusion syndrome (with or without permanent deficit) was similar (<i>P</i> = 1) in preoperatively symptomatic patients versus asymptomatic patients (9.8% vs 5.9%). Internal carotid artery diameter consistently increased after carotid artery stent placement in patients with collapse and was not related to the development of hyperperfusion syndrome. <h3>CONCLUSIONS:</h3> Care should be taken to minimize hyperperfusion risk in patients with near-occlusion undergoing CAS, especially in the subgroup of patients with collapse and in patients with both symptomatic and asymptomatic carotid stenosis.
Soluble HLA-G dampens CD94/NKG2A expression and function and differentially modulates chemotaxis and cytokine and chemokine secretion in CD56bright and CD56dim NK cells
Authors: Fabio Morandi, Elisa Ferretti, Roberta Castriconi, Alessandra Dondero, Andrea Petretto, Cristina Bottino, Vito Pistoia
Journal: Blood (2011)
Metabolism of 59Fe-Dextran Complex in Human Subjects
Authors: A. J. Grimes, M. S. R. Hutt
Journal: BMJ (1957)

MEDICAL JOURNAL___treatment for acute rheumatism led to reinvestigation of the effect of salicylate in diabetes mellitus.An intensive two-weeks course of aspirin abolished glycosuria and lowered the fasting blood sugar to normal or near normal in seven mild to moderately severe diabetics.No decisive effect on glucose tolerance was obtained, though the blood-sugar curves were always lower during aspirin administration than they were either before or after.Moderate ketonuria in two patients was reduced to normal with aspirin.Clinical improvement accompanied the biochemical changes induzed by aspirin, and, while serious toxic manifestations were not conspicuous, tinnitus and deaf- ness were annoying.The possible place of aspirin in the treatment of diabetes mellitus is discussed.The action of aspirin in diabetes mellitus has been located in the tissues.and this is of interest in the light of the proper establishment of the drug as a peripheral- acting metabolic stimulant.We thank Miss M. McCombie and staff of the dietetic depart- ment of the Wectern Infirmary for careful preparation and super- vision of the diets.
Misuse of alcohol or drugs by elderly people
Authors: F J Dunne
Journal: BMJ (1994)

postoperative pulmonary complications, and better chances of long term graft patency.3'471618Patients who continue to smoke but in whom the arterial disease is not yet critical should be reminded that the operative risk and chance of bypass failure remain too high to justify surgery.Nevertheless, if the disease progresses no smoker should be denied urgent surgery to prevent amputation, stroke, or death.
1280 DIETARY IRON OVERLOAD INDUCES VISCERAL ADIPOSE TISSUE INSULIN RESISTANCE ASSOCIATED WITH HYPER-RESISTINEMIA, AND SYNERGIZES WITH OBESITY AND FATTY LIVER IN INDUCING SYSTEMIC INSULIN RESISTANCE
Authors: P. Dongiovanni, M. Ruscica, L. Benedan, V. Borroni, S. Recalcati, L. Steffani, G. Cairo, P. Magni, F. Caprioli, S. Gatti, S. Fargion, L. Valenti
Journal: Journal of Hepatology (2011)
Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation
Authors: Bérengère Coupé, Yuko Ishii, Marcelo O. Dietrich, Masaaki Komatsu, Tamas L. Horvath, Sebastien G. Bouret
Journal: Cell Metabolism (2012)
RIPPLE EFFECTS OF A NOVEL D2B PATHWAY
Authors: Monica G. Sanchez-Ross, James M. Maher, Mike Kasper, Gerard Oghlakian, Brijesh Patel, Vivek N. Dhruva, Edo Kaluski, David Langley, William Dougan, Diane Alfano, Marc Klapholz
Journal: Journal of the American College of Cardiology (2010)
Collaboration between regulators and industry on design of drugs could reduce errors
Authors: Lisa Hitchen
Journal: BMJ (2007)

Drug regulators could work more closely with manufacturers and patient safety organisations to reduce treatment errors, experts on patient safety told a conference last week.

The design of drugs and their packaging, nomenclature of different products, and labelling all contributed to some of the 6000 drug treatment errors reported every month to the UK National Patient Safety Agency's national reporting and learning system from June 2006 to May 2007, Bruce Warner, senior pharmacist for the agency, told the conference in London on reducing treatment errors, which was organised by Healthcare Events.

One example was the similarity in trade names between the proton pump inhibitor omeprazole, which is sold as Losec, and the diuretic furosemide, marketed as Lasix, said David Williams, the clinical pharmacology lead for patient safety research at the University of Aberdeen.

In the United States a decision had been made to change the name …
Antibiotic Usage in Seven Community Hospitals
Authors: William E. Scheckler
Journal: JAMA (1970)

Between November 1967 and June 1969,24 prevalence studies of nosocomial infections and antibiotic usage were completed in seven community hospitals. Medical records of 5,256 patients were reviewed; 30.6% were receiving antibiotics, and 80% of those were receiving a single agent. Penicillin, ampicillin, and tetracycline use was similar, and these three accounted for about half of the antibiotics given. From January 1968 through June 1969, chloramphenicol use declined sharply; ampicillin and cephalosporin use increased. Antibiotics were used most frequently on the pediatric and surgical services. They were most frequently used without clearly recorded evidence of infection on the surgical services. Fewer than 30% of patients receiving penicillin, sulfonamides, and streptomycin had recorded evidence of infection when the antibiotic was first given; only 38% of 454 patients receiving antibiotics in 1969 had such evidence.
457 Retreatment with pegylated interferon alpha-2B and ribavirin in patients with chronic hepatitis C non responders to interferon monotherapy or interferon and ribavirin combination. A prospective randomized pilote study of two regimens: Induction versus REG
Authors: C. Bapin, P. Fabbro-Peray, S. Hachemane, F. Blanc, D. Diaz, P. Pueyo, D. Larrey
Journal: Journal of Hepatology (2004)
Brachytherapy optimal planning with application to intravascular radiation therapy
Authors: Payman Sadegh, Firas A. Mourtada, Russell H. Taylor, James H. Anderson
Journal: Medical Image Analysis (1999)

We have been studying brachytherapy planning with the objective of minimizing the maximum deviation of the delivered dose from prescribed dose bounds for treatment volumes. A general framework for optimal treatment planning is presented and the minmax optimization is formulated as a linear program. Dose rate calculations are based on the dosimetry formulation of the American Association of Physicists in Medicine, Task Group 43. We apply the technique to optimal planning for intravascular brachytherapy of intimal hyperplasia using ultrasound data and 192Ir seeds. The planning includes determination of an optimal dwell-time sequence for a train of seeds that deliver radiation while stepping through the vessel lesion. The results illustrate the advantage of this strategy over the common approach of delivering radiation by positioning a single train of seeds along the whole lesion.
Consultation with a Group of Wardens from the London Area of the Y.W.C.A
Authors: Margaret Robinson
Journal: Psychotherapy and Psychosomatics (1968)

Research Articles| February 12 2010 Consultation with a Group of Wardens from the London Area of the Y.W.C.A Subject Area: Psychiatry and Psychology Margaret Robinson Margaret Robinson London Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1968) 16 (1-3): 91–99. https://doi.org/10.1159/000285921 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Margaret Robinson; Consultation with a Group of Wardens from the London Area of the Y.W.C.A. Psychother Psychosom 31 December 1968; 16 (1-3): 91–99. https://doi.org/10.1159/000285921 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1968Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.