tbuckley/cabot-search huggingface dataset:
Replication of the human immunodeficiency virus 1 and impaired differentiation of T cells after in vitro infection of bone marrow immature T cells.
Authors: Y Lunardi-Iskandar, M T Nugeyre, V Georgoulias, F Barré-Sinoussi, C Jasmin, J C Chermann
Journal: Journal of Clinical Investigation (1989)

HIV-1 infection in vitro of normal bone marrow mononuclear cells (BMMC) depleted of mature T cells was studied. BMMC depleted of either CD3, CD2, or both could replicate HIV-1 irrespective of the presence of macrophages/monocytes. Infected bone marrow cells were shown to differentiate during the culture into CD3+, CD4+, CD8+, and CD1+ cells, whereas noninfected BMMC gave rise to CD3+, CD4+, and CD8+ cells. Moreover, 9-14% of the cells also expressed the viral proteins p24 and gp120 on their surface. Double staining studies revealed that 72 and 83% of the CD4+ cells expressed the gp120 and p24, respectively, suggesting that virus replication occurred in CD4+ cells. T cell colony growth from infected BMMC, either unfractionated or depleted of mature T cells, was impaired in a time-dependent manner, and the differentiation capacity of T cell precursors was abnormal. Colony cells displayed an immature cell phenotype (CD1+ cells) and the viral proteins gp120 and/or p24 could also be detected on CD1+ cells. In addition, pooled colony cells derived from infected CD2- and CD3-depleted BMMC could infect normal mitogen-activated lymphocytes in coculture experiments. These findings strongly suggest that HIV-1 can infect immature bone marrow T cells and be transmitted to the progeny, but the massive viral replication occurs only when the cells differentiate toward CD4+ cells.
Potential health effects of gasoline and its constituents: A review of current literature (1990-1997) on toxicological data.
Authors: L Caprino, G I Togna
Journal: Environmental Health Perspectives (1998)

We reviewed toxicological studies, both experimental and epidemiological, that appeared in international literature in the period 1990-1997 and included both leaded and unleaded gasolines as well as their components and additives. The aim of this overview was to select, arrange, and present references of scientific papers published during the period under consideration and to summarize the data in order to give a comprehensive picture of the results of toxicological studies performed in laboratory animals (including carcinogenic, teratogenic, or embryotoxic activity), mutagenicity and genotoxic aspects in mammalian and bacterial systems, and epidemiological results obtained in humans in relation to gasoline exposure. This paper draws attention to the inherent difficulties in assessing with precision any potential adverse effects on health, that is, the risk of possible damage to man and his environment from gasoline. The difficulty of risk assessment still exists despite the fact that the studies examined are definitely more technically valid than those of earlier years. The uncertainty in overall risk determination from gasoline exposure also derives from the conflicting results of different studies, from the lack of a correct scientific approach in some studies, from the variable characteristics of the different gasoline mixtures, and from the difficulties of correctly handling potentially confounding variables related to lifestyle (e.g., cigarette smoking, drug use) or to preexisting pathological conditions. In this respect, this paper highlights the need for accurately assessing the conclusive explanations reported in scientific papers so as to avoid the spread of inaccurate or misleading information on gasoline toxicity in nonscientific papers and in mass-media messages.
P750 SPONTANEOUS HCV CLEARANCE IN HIV PATIENTS WITH CHRONIC HEPATITIS C BEARING FAVORABLE IL28B ALLELES ON ANTIRETROVIRAL THERAPY
Authors: E. Vispo, P. Barreiro, J.V. Fernandez-Montero, P. Labarga, C. de Mendoza, A. Treviño, V. Soriano
Journal: Journal of Hepatology (2014)
Local Chemotherapy in Cutaneous Neoplasms
Authors: Edmund Klein
Journal: JAMA (1972)

Local chemotherapy was explored<sup>1,2</sup>as part of a broader program in oncology in which supportive care, utilizing blood components<sup>3,4</sup>and immunotherapeutic approaches were studied and developed as therapeutic methods<sup>5,6</sup>for comprehensive care in cancer.<sup>7</sup> Our studies, which led to the development of local chemotherapy as a new treatment modality<sup>8</sup>have been carried out in over 500 patients with an aggregate of more than 15,000 neoplastic lesions for observation periods in excess of five years. Topical chemotherapy with fluorouracil (5FU) was shown to result in selective eradication of premalignant and superficial malignant lesions of the skin. Since the action of 5-FU is selective, it produces minimal or no effects on normal tissues adjacent to tumors. Healing therefore occurs with slight or no apparent scarring. Topical chemotherapy is indicated for solar keratoses and other precancerous lesions, as well as for multiple superficial primary skin cancers, including selected
Adding radiotherapy to endocrine therapy improved survival in locally advanced prostate cancer
Authors: Julio Hajdenberg
Journal: Annals of Internal Medicine (2009)

Source Citation Widmark A, Klepp O, Solberg A, et al. Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial. Lancet. 2009;373:301-8. 19091394
Spontaneous resolution of severe aplastic anemia associated with viral hepatitis a in a 6‐year‐old child
Authors: Dean Smith, T. John Gribble, Anne S. Yeager, Herbert C. Schwartz, William Robinson, Harry B. Greenberg, Robert H. Purcell
Journal: American Journal of Hematology (1978)

Abstract Recovery from acquired aplastic anemia associated with hepatitis is rare. This case of a 6‐year‐old boy with severe aplastic anemia is the first reported association of this disease with a hepatitis A infection. Antibody to hepatitis A (anti‐HA) was not detected on admission, but was detected three weeks later. Infection with hepatitis B virus, cytomegalovirus (CMV), and Epstein‐Barr virus (EBV) were excluded. The peak titer of anti‐HA was higher than would be expected for passive transfer of antibody resulting from transfusions. The persistence of antibody for more than 20 months after the last transfusion was not consistent with passive antibody, which would be expected to disappear over that time. This child had indications for allogeneic marrow transplant and a sibling donor who was histocompatible. However, the transplant was postponed because the prognosis was considered to be poor in the presence of active hepatitis. There was a spontaneous remission without the necessity of the transplantation procedure.
NHS publishes new data on patient reported health outcomes
Authors: J. Wise
Journal: BMJ (2010)

The first study of patient reported outcome measures (PROMs) for four surgical procedures in NHS hospitals in England has been published.

PROMs are self completed questionnaires that measure a patient’s health status or health related quality of life. Since April 2009 it has been a requirement for all providers of NHS funded hip replacements, knee replacements, groin hernia surgery, or varicose vein surgery to collect these data from patients before and after the procedures.

The data, from April 2009 to April 2010, have now been published by the NHS Information Centre, whose chief executive, Tim Straughan, said, “PROMs are a very exciting development in the way we consider the quality and value of care being delivered to patients. This is the first time this type of information has been gathered on such a large scale, and it will be of enormous interest to those charged …
Medical practice guidelines: lessons from the United States.
Authors: A Farmer
Journal: BMJ (1993)

Clinical guidelines, or protocols, have been devised by many different groups, often with differing aims. Some aim to reduce variations in care by using guidelines, while others seek to improve outcomes. Guidelines have long been used in the United States to try to control the behaviour of the medical profession--and the cost of health care. The "effectiveness initiative," run by the Agency for Health Care Policy and Research spawned much activity among other groups, including the American Medical Association and the American College of Physicians. The experience of the Americans in analysing data to gauge effectiveness and then in disseminating good practice may help British moves in this direction. In particular, it is often hard to get guidelines adopted in practice; doctors have to be exposed to the same message in different forms. Also guidelines must not be unrealistic: those devised by senior doctors away from the realities of day to day practice are likely to fail.
Treatment of axillary hyperhidrosis.
Authors: H Yarrow
Journal: BMJ (1981)

supplied by Bio-Rad Laboratories.Approximately 70-80% of the fast haemoglobin fraction measured by this technique is HBALC.2Two units of whole blood, collected in ordinary donor bags with citrate phosphate dextrose, were stored at 4°C and tested on days 1, 3, 7, 15, 21, and 28.Storage of red cells in citrate phosphate dextrose: follow up of values of HbAj, hydrogen ion concen- tration, and glucose concentration Day of Mean % Mean Mean glucose storage IIbA, pH concentration (mmol/l)
Excretion of Levofloxacin into Bile and Gallbladder Tissue
Authors: H. Ohnishi, H. Tanimura, G. Ichimiya, Y. Aoki, K. Ishimoto, S. Oka, Y. Kobayashi, H. Yamaue, K. Uchiyama, M. Ochiai, M. Uenishi
Journal: Drugs (1993)
Churg-Strauss Syndrome
Authors: Santosh B. Murthy, Natalia Khalaf, Shreyansh Shah, Brandy Ma, Corey E. Goldsmith, Joseph S. Kass
Journal: JAMA Neurology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Management Setting of Obstructive Sleep Apnea
Authors: Samuel A. Fleishman
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bone morphogenetic proteins induce apoptosis in multiple myeloma cells by Smad-dependent repression of MYC
Authors: T Holien, T K Våtsveen, H Hella, C Rampa, G Brede, L A G Grøseth, M Rekvig, M Børset, T Standal, A Waage, A Sundan
Journal: Leukemia (2011)
Late failure of vasectomy after two documented analyses showing azoospermic semen.
Authors: T Philp, J Guillebaud, D Budd
Journal: BMJ (1984)

From April 1970 to December 1980, 14 047 men underwent vasectomy for sterilisation under local anaesthetic at this clinic. In each man sterility was confirmed by two analyses of semen showing azoospermia. Allowing for a minimum follow up of three years, the wives of six of these men subsequently became pregnant between 16 months and three years after vasectomy. Analyses of semen confirmed recanalisation of the vasa deferentia in all six men. Only five similar cases initially fulfilling the same criteria for sterility have previously been reported. Full account of the rare possibility of recanalisation should be taken both when couples are counselled preoperatively and when pregnancy occurs after the male partner has been confirmed to be sterile.
Host Resistance to Intracellular Infection: Mutation of Natural Resistance-associated Macrophage Protein 1 (<i>Nramp1</i>) Impairs Phagosomal Acidification
Authors: David J. Hackam, Ori D. Rotstein, Wei-jian Zhang, Samantha Gruenheid, Philippe Gros, Sergio Grinstein
Journal: The Journal of Experimental Medicine (1998)

The mechanisms underlying the survival of intracellular parasites such as mycobacteria in host macrophages remain poorly understood. In mice, mutations at the Nramp1 gene (for natural resistance-associated macrophage protein), cause susceptibility to mycobacterial infections. Nramp1 encodes an integral membrane protein that is recruited to the phagosome membrane in infected macrophages. In this study, we used microfluorescence ratio imaging of macrophages from wild-type and Nramp1 mutant mice to analyze the effect of loss of Nramp1 function on the properties of phagosomes containing inert particles or live mycobacteria. The pH of phagosomes containing live Mycobacterium bovis was significantly more acidic in Nramp1- expressing macrophages than in mutant cells (pH 5.5 ± 0.06 versus pH 6.6 ± 0.05, respectively; P &amp;lt;0.005). The enhanced acidification could not be accounted for by differences in proton consumption during dismutation of superoxide, phagosomal buffering power, counterion conductance, or in the rate of proton “leak”, as these were found to be comparable in wild-type and Nramp1-deficient macrophages. Rather, after ingestion of live mycobacteria, Nramp1-expressing cells exhibited increased concanamycin-sensitive H+ pumping across the phagosomal membrane. This was associated with an enhanced ability of phagosomes to fuse with vacuolar-type ATPase–containing late endosomes and/or lysosomes. This effect was restricted to live M. bovis and was not seen in phagosomes containing dead M. bovis or latex beads. These data support the notion that Nramp1 affects intracellular mycobacterial replication by modulating phagosomal pH, suggesting that Nramp1 plays a central role in this process.
US Sticks Head in the Sand on AIDS Prevention
Authors: Paul Cotton
Journal: JAMA (1994)

THE UNITED STATES likes to think of itself as the world leader in health care sophistication. Yet it is among the most backward nations when it comes to AIDS prevention. This embarrassment was underscored during the 10th International Conference on AIDS in Yokohama, Japan. While success with explicit, school-based education programs elsewhere was being documented, the US Senate passed amendments that, if approved by the House and enacted into law, will cut off federal funds to schools that take a clear approach to sexual behavior. The kinds of educational materials that enable adolescents to protect themselves from human immunodeficiency virus (HIV) infection as they explore their emerging sexuality, such as how to use a condom or the realities of homosexuality, were decried as "disgusting" and "obscene" on the Senate floor by Sen Jesse Helms (R, NC) in debate on amendments that were added to the Elementary and Secondary School Act.
441 HCV CORE-SPECIFIC ADAPTIVE CD4+ REGULATORY T CELL CLONES IN CHRONIC HEPATITIS C ARE HIGHLY SUSCEPTIBLE TO INHIBITION BY RIBAVIRIN
Authors: B. Langhans, I. Braunschweiger, S. Arndt, W. Schulte, N. Vidovic, J. Oldenburg, T. Sauerbruch, U. Spengler
Journal: Journal of Hepatology (2010)
Abstract 11805: A Community-Based Program to Improve Heart Failure Self-Care
Authors: Victoria Dickson, Alissa Levine Wong, Judy Dillworth, Sarah R'Bibo, Stuart Katz, Gail D'Eramo Melkus
Journal: Circulation (2011)

The prevalence of heart failure (HF) among elders is 6.6-9.4%. Despite advances in HF treatment, outcomes remain dismal including poor quality of life, increased healthcare utilization and early mo...
Poly(lactide-co-glycolide) microspheres for MRI-monitored transcatheter delivery of sorafenib to liver tumors
Authors: Jeane Chen, Alexander Y. Sheu, Weiguo Li, Zhuoli Zhang, Dong-Hyun Kim, Robert J. Lewandowski, Reed A. Omary, Lonnie D. Shea, Andrew C. Larson
Journal: Journal of Controlled Release (2014)
Pharmaceutical Manufacturers and the Great American Fraud
Authors: W. R. Tymms
Journal: JAMA (1910)

<h3>To the Editor:</h3> In commenting in your issue of July 30, on Dr. Patek's letter concerning "Pharmaceutical Manufacturers and the Great American Fraud" you say that "the whole history of human progress shows that practically everything we now pronounce necessary to our comfort and material happiness has been brought into being for selfish reasons—that of bringing the inventor or discoverer riches or honor." The sentence might, I think, well be rounded off by adding "or the pleasure of following a congenial vocation." (Recall Bacon's "Happy men whose natures sort with their vocations"). The suggested addition would perhaps justify the toning down of the word "selfish" to "self-regarding." A very brilliant author of our day somewhere says that all labor done for hire, which would not be done had the laborer an otherwise assured means of livelihood, is prostituted labor; and his epigrammatic phrase seems to reflect the views of authors
Mutation (677 C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients
Authors: Manuela Födinger, Christine Mannhalter, Gabriele Wölfl, Ingrid Pabinger, Eva Müller, Rainer Schmid, Walter H. Hörl, Gere Sunder-Plassmann
Journal: Kidney International (1997)
AN UNSATURATED FATTY ACID FRACTION OF PIG PANCREAS WHICH INHIBITS THE GROWTH OF CHICKEN SARCOMA
Authors: O. M. Helmer
Journal: The Journal of Experimental Medicine (1936)

The inhibiting action of pancreatic tissue was found to be associated with the unsaturated fatty acid fraction. As small an amount of fatty acid as 0.1 mg. inhibited the chicken sarcoma agent contained in 0.2 cc. of a 1:60 aqueous extract of Chicken Tumor I. The unsaturated fatty acid had an acid number and an iodine number similar to those for oleic acid. Commercial oleic acid also was found to inhibit the growth of the chicken sarcoma in comparable quantities.
Elevated Serum Lipoprotein(a) Is a Risk Factor for Clinical Recurrence After Coronary Balloon Angioplasty
Authors: Rene L. Desmarais, Ian J. Sarembock, Carlos R. Ayers, Sarah M. Vernon, Eric R. Powers, Lawrence W. Gimple
Journal: Circulation (1995)

Background Elevated lipoprotein (Lp) (a) concentrations are associated with coronary artery disease and myocardial infarction. Lp(a) is structurally related to proteins involved in lipid transport, fibrinolysis, coagulation, and cellular mitogenesis and is known to have important physiological interactions with the coagulation and fibrinolytic systems. Because these processes may be important to arterial healing after balloon injury, we hypothesized that elevated Lp(a) concentrations may be associated with recurrence of symptoms and restenosis after balloon angioplasty. Methods and Results We assessed 240 consecutive patients undergoing coronary balloon angioplasty with measurements of Lp(a), total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, apolipoprotein A-I, and apolipoprotein B-100 concentrations from fresh specimens. Patients were evaluated 4 to 6 months after angioplasty for clinical recurrence by repeat angiography if angina had returned or by maximal exercise treadmill testing with thallium imaging if patients remained asymptomatic. Ninety-seven patients (40%) had clinical recurrence; 143 (60%) did not. Patients with recurrence had significantly greater Lp(a) concentrations compared with those without (median, 29 versus 14; P &lt;.0001). Each patient quintile stratified by increasing Lp(a) concentrations had incrementally greater recurrence rates ranging from 27% (lowest quintile) to 60% (highest quintile). By multivariate logistic regression analysis, Lp(a) concentration was the only predictor of recurrence ( P &lt;.0001). A subset of frozen, stored serum samples showed a significant decrease in measured Lp(a) concentration over time (mean, 605 days; P &lt;.01). Conclusions An elevated Lp(a) concentration was a risk factor for clinical recurrence after percutaneous transluminal balloon coronary angioplasty. Other lipid levels or clinical characteristics were not significantly associated with recurrence. When serum was frozen and stored for a prolonged period, Lp(a) concentration decreased over time.
Treatment of dermatitis herpetiformis with corticosteroids and a gluten-free diet: a study of jejunal morphology and function
Authors: P. J. Kumar, D. B. A. Silk, R. Marks, M. L. Clark, A. M. Dawson
Journal: Gut (1973)

The jejunal morphological and functional response to either a gluten-free diet or corticosteroid therapy was studied in six patients with dermatitis herpetiformis. In each treatment group there were two patients with subtotal villous atrophy and one with partial villous atrophys. After treatment, in both groups, morphological improvement was seen in villous and surface cell heights, mucosal thickness, and intraepithelial lymphocyte counts. Jejunal function was assessed using the perfusion technique. Absorption of glucose from a 56 mM solution was shown to improve. Water movement from this solution was in a secretory state in four patients (two in each group) before treatment and moved into the normal absorptive range after treatment. These results further outline the similarity between the mucosal lesion of dermatitis herpetiformis and true coeliac disease.
HB8: a monoclonal antibody recognizing elastic fibre microfibrils
Authors: D. SCHMITT, MARIE-CHRISTINE CHIGNOL, J. BROCHIER, J. THIVOLET
Journal: British Journal of Dermatology (1986)

We report an ultrastructural study of the reactivity of an IgG monoclonal antibody, which reacts with human dermal elastic fibres. On electron microscopy, immunogold labelling demonstrated the reactivity of HB8 with the microfibrillar component of the fibres. In contrast, the electron-dense granular component which contains elastin was unlabelled with HB8. A fine network of microfibrils from the level of the oxytalan fibres to the large elastic fibres of the deep dermis was labelled with gold particles. No reactivity was detected on collagen fibres. These results demonstrate that HB8 reacts with the microfibrillar glycoproteins of the elastic fibres in normal skin. The precise biochemical nature of the antigens identified by HB8 is still unknown.