Diabetes Mellitus Induced by Megestrol Acetate in a Patient with AIDS and Cachexia
Authors: Keith Henry, Scott Rathgaber, Christopher Sullivan, Kathleen McCabe
Journal: Annals of Internal Medicine (1992)

Brief Reports1 January 1992Diabetes Mellitus Induced by Megestrol Acetate in a Patient with AIDS and CachexiaKeith Henry, MD, Scott Rathgaber, MD, Christopher Sullivan, MD, Kathleen McCabe, RNKeith Henry, MD, Scott Rathgaber, MD, Christopher Sullivan, MD, Kathleen McCabe, RNAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-1-53 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMegestrol acetate has been reported to be a relatively nontoxic drug (1, 2) that is efficacious in the treatment of cachexia associated with the acquired immune deficiency syndrome (AIDS) (3). We report the case of a patient with AIDS who developed diabetes mellitus requiring insulin therapy 13 weeks after beginning megestrol therapy and who experienced an exacerbation of his diabetes when rechallenged with megestrol.Case ReportA 46-year-old man had been diagnosed with AIDS 2.5 years earlier when a skin biopsy specimen showed Kaposi sarcoma. His treatment regimen is summarized in Figure 1. Before beginning therapy with megestrol acetate, his...References1. McEvoy G ed. American Hospital Formulary Service Drug Information. Bethesda, Maryland. American Society of Hospital Pharmacists; 1990:526-7. Google Scholar2. . 1991. Oradell, New Jersey; Medical Economics Company, Inc.; 1991:728-9. Google Scholar3. Von RoennMurphyWeberWilliamsWeitzman JRKLS. Megestrol acetate for treatment of cachexia associated with human immunodeficiency virus (HIV) infection. Ann Intern Med. 1988:109:840-841. LinkGoogle Scholar4. SchacterRozencweigCanettaKelleyNicaiseSmaldone LMRSCL. Overview of hormonal therapy in advanced breast cancer. Semin Oncol. 1990;17(Suppl 9):38-46. MedlineGoogle Scholar5. Otteman L. Hypercalcemic flare with megestrol acetate [Letter]. Cancer Treat Rep. 1984;68:1420-1. MedlineGoogle Scholar6. FoitlHymanKefkowitch DGJ. Jaundice and intrahepatic cholestasis following high-dose megestrol acetate for breast cancer. Cancer. 1989:63:438-9. CrossrefMedlineGoogle Scholar7. HellersteinKahnMudieViteri MJHF. Current approach to the treatment of human immunodeficiency virus-associated weight loss: pathophysiologic considerations and emerging management strategies. Semin Oncol. 1990;17(Suppl 9):17-33. MedlineGoogle Scholar8. Von RoennMurphyWegener JRN. Megestrol acetate for treatment of anorexia and cachexia associated with human immunodeficiency virus infection. Semin Oncol. 1990;17(Suppl 9):13-6. MedlineGoogle Scholar9. Furth P. Megestrol acetate and cachexia associated with human immunodeficiency virus (HIV) infection [Letter]. Ann Intern Med. 1989:110:667. LinkGoogle Scholar10. NathwaniGreenHeslopGoldbergKennedy DSJDD. Beneficial response to megoestrol acetate in AIDS-related cachexia and a possible megoestrol withdrawal-associated syndrome? Acta Derm Venereol (Stockh). 1990;70:520-1. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From St. Paul-Ramsey Medical Center, St. Paul, Minnesota. For current author addresses, see end of text. 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Panwalker, MDMegestrol 1 January 1992Volume 116, Issue 1Page: 53-54KeywordsAIDSBiopsyDiabetes mellitusDrugsInsulinKaposi sarcoma Issue Published: 1 January 1992 PDF downloadLoading ...