Disseminated Gonococcal Infection Caused by Chromosomally Mediated Penicillin-Resistant Organisms
Authors: KYLE W. STRADER
Journal: Annals of Internal Medicine (1986)

Brief Reports1 March 1986Disseminated Gonococcal Infection Caused by Chromosomally Mediated Penicillin-Resistant OrganismsKYLE W. STRADER, M.D., CHRISTOPHER M. WISE, M.D., BENEDICT L. WASILAUSKAS, M.D., WILLIAM L. SALZER, M.D.KYLE W. STRADER, M.D.Search for more papers by this author, CHRISTOPHER M. WISE, M.D.Search for more papers by this author, BENEDICT L. WASILAUSKAS, M.D.Search for more papers by this author, WILLIAM L. SALZER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-3-365 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPlasmid-Mediated (beta-lactamase positive) and chromosomally mediated (beta-lactamase negative) forms of penicillin resistance have been reported with mucosal Neisseria gonorrhoeae isolates (1, 2). However, there have only been six reported cases of disseminated gonococcal infections with beta-lactamase-producing organisms (3-5), and no reports documenting isolation of chromosomally mediated penicillin-resistant organisms from a disseminated site. We report the isolation of N. gonorrhoeae that was beta-lactamase negative but highly resistant to penicillin from the synovial fluid of two patients.Organisms were identified asN. gonorrhoeaeon the basis of Gram stain, oxidase testing, and sugar fermentation reactions. Beta-lactam reagent disks (Marion Laboratories, Kansas City,...References1. JAFFEBIDDLEJOHNSONWIESNER HJSP. Infections due to penicillinase-producing Neisseria gonorrhoeae in the United States: 1976-1980. J Infect Dis. 1981;144:191-7. CrossrefMedlineGoogle Scholar2. FARUKIKOHMESCHERMCKINNEYSPARLING HRWP. A community-based outbreak of infection with penicillin-resistant Neisseria gonorrhoeae not producing penicillinase (chromosomally mediated resistance). N Engl J Med. 1985;313:607-14. CrossrefMedlineGoogle Scholar3. THOMPSONDUNBARVAN GENTVAN FURTH JJAR. Disseminated gonococcal infection due to a beta-lactamase-producing strain of Neisseria gonorrhoeae: a case report. Br J Vener Dis. 1981;57:325-6. MedlineGoogle Scholar4. RINALDIHARRISONFAN RWP. Penicillin-resistant gonococcal arthritis: a report of four cases. Ann Intern Med. 1982;97:43-5. LinkGoogle Scholar5. RUUTURAJALAREPOHIRVONENLÄHDEVERTA PRHPJ. Septicemia caused by penicillinase-producing gonococcus. JAMA. 1984;251:1836. CrossrefMedlineGoogle Scholar6. THORNSBERRYKIRVEN CL. Ampicillin resistance in Haemophilus influenzae as determined by a rapid test for beta lactamase production. Antimicrob Agents Chemother. 1974;6:653-4. CrossrefMedlineGoogle Scholar7. LENNETTEBALOWSHAUSLERSHADOMY EAWH eds. Manual of Clinical Microbiology. 4th ed. Washington D.C.: American Society for Microbiology; 1985: 972-7. Google Scholar8. BARRDANIELSSON JD. Septic gonococcal dermatitis. Br Med J. 1971;1:482-5. CrossrefMedlineGoogle Scholar9. WIESNERHANDSFIELDHOLMES PHK. Low antibiotic resistance of gonococci causing disseminated infection. N Engl J Med. 1973;288:1221-2. CrossrefMedlineGoogle Scholar10. O'BRIENGOLDENBERGRICE JDP. Disseminated gonococcal infection: a prospective analysis of 49 patients and a review of pathophysiology and immune mechanisms. Medicine. 1983;62:395-406. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: KYLE W. STRADER, M.D.; CHRISTOPHER M. WISE, M.D.; BENEDICT L. WASILAUSKAS, M.D.; WILLIAM L. SALZER, M.D.Affiliations: North Carolina Baptist Hospital Winston-Salem; North Carolina PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCutaneous gonococcal infectionsArthritis due to a penicillinase-producingNeisseria gonorrhoeae from Saudi ArabiaRheumatic Disease in the Intensive Care Unit: Acute Septic Arthritis and Giant-Cell ArteritisAntimicrobial susceptibility testing of Neisseria gonorrhoeae and implications for epidemiology and therapySexually transmitted diseases: Bacterial infectionsGonococcal InfectionsEvaluation of five rapid systems for the identification of Neisseria gonorrhoeaeSignes cutanés des gonococcies disséminéesSexually Transmitted Diseases in BlacksDisseminated Multiple Antibiotic-Resistant Gonococcal Infection: Needed Changes in Antimicrobial TherapyLARRY M. BUSH, M.D., JEROME A. BOSCIA, M.D.Understanding penicillin-binding proteins 1 March 1986Volume 104, Issue 3Page: 365-366KeywordsChromosomesGonorrheaNeisseria gonorrhoeaePenicillinRheumatologySynovial fluid ePublished: 1 December 2008 Issue Published: 1 March 1986 PDF downloadLoading ...