tbuckley/cabot-search huggingface dataset:
Energy expenditure in children with type I diabetes: evidence for increased thermogenesis.
Authors: M. J. Muller, A. von zur Muhlen, H. U. Lautz, F. W. Schmidt, M. Daiber, P. Hurter
Journal: BMJ (1989)

The aim of the study was to assess whether increased energy expenditure causes the negative energy balance (tissue catabolism) commonly seen in children with insulin dependent (type I) diabetes. Resting metabolic rate and thermogenesis induced by adrenaline were measured in five healthy children and 14 children with type I diabetes who were all free of clinical signs of late complications of diabetes mellitus but differed in their degree of glycaemic control (in eight glycated haemoglobin concentration was less than 10% and in the six others greater than or equal to 10%). When compared with the control subjects children with type I diabetes had normal resting metabolic rates but their urinary nitrogen excretion was significantly raised (11.5 (SD 5.4) mg/min in those with glycated haemoglobin concentration less than 10%, 11.6 (5.2) mg/min in those with concentration greater than or equal to 10% v 5.4 (3.0) mg/min in control subjects). During the infusion of adrenaline the diabetic children showed a threefold and sustained increase in thermogenesis and disproportionate increases in the work done by the heart, in lipid oxidation rate, and in plasma concentrations of glucose, free fatty acids, and ketone bodies. The increased thermogenic effect of adrenaline did not correlate with the degree of glycaemic control. Increased thermogenesis may explain the tissue wasting commonly seen in children with type I diabetes during intercurrent stress.
Felic (CIP4b), a novel binding partner with the Src kinase Lyn and Cdc42, localizes to the phagocytic cup
Authors: Patrice Dombrosky-Ferlan, Anatoly Grishin, Roberto J. Botelho, Matthew Sampson, Lin Wang, William A. Rudert, Sergio Grinstein, Seth J. Corey
Journal: Blood (2003)
Circulating immune complexes in polymyalgia rheumatica and giant cell arteritis.
Authors: J.R Park, J.G Jones, G.D Harkiss, B.L Hazleman
Journal: Annals of the Rheumatic Diseases (1981)

Sera from patients with giant cell arteritis and/or polymyalgia rheumatica have been found to contain increased levels of circulating immune complexes (IC). Results with the polyethyleneglycol precipitation complement consumption (PEG-CC) assay have been correlated with disease activity. 44% of samples from an active untreated group (21 patients) had increased levels of ICs compared with 23% from an inactive treated group (49 patients). Further analysis of circulating ICs was performed by 125I-Clq binding, the PEG-C4 test, and 125I-conglutinin binding assays. Although we did not find a high correlation between IC levels and disease activity, isolation and analysis of the ICs may lead to further understanding of this disorder.
Hypersomnolence and Intermittent Upper Airway Obstruction
Authors: William A. Conway
Journal: JAMA (1977)

A patient with hypersomnolence, micrognathia, and respiratory insufficiency had been treated eight years for narcolepsy. Sleep apnea because of upper airway obstruction was found, and a tracheostomy was performed. Following this the hypersomnolence and respiratory insufficiency resolved. This case emphasizes the importance of carefully evaluating the condition of patients complaining of hypersomnolence to detect those with intermittent upper airway obstruction occurring during sleep.
Malabsorption During and After Recovery from Acute Intestinal Infection
Authors: J. Lindenbaum
Journal: BMJ (1965)

Amer. Rev. resp. Dis., 1963, 88, part 2. Badger, G. F., Dingle, J. H., Feller, A. E., Hodges, R. G., Jordan, W. S., jun., and Rammelkamp, C. H., jun. (1953). Amer. J. Hyg., 58, 174. Banatvala, J. E., Anderson, T. B., and Reiss, B. B. (1964). Brit. med. J.y 1, 537. Buck, C. (1956). Amer. J. Hyg., 63, 1. Chanock, R. M., Bell, J. A., and Parrott, R. H. (1961). In Perspectives in Virology, edited by M. Pollard, 2, 126. Chapman and Hall, London. Parrott, R. H., Cook, K., Andrews, B. E., Bell, J. A., Reichelderfer, T., Kapikian, A. Z., Mastrota, F. M., and Huebner, R. J. (1958). New Engl. J. Med., 258, 207. Clarke, S. K. R., Corner, B. D., Gambier, D. M., Macrae, J., and Peacock, D. B. (1964). Brit. med. J., 1, 1536. Dimmock, N. J., and Tyrrell, D. A. J. (1962). Lancet, 2, 536. Gamble, D. R., and Kinsley, M. L. (1963). Mth. Bull. Minist. Hlth Lab. Serv., 22, 6. Gardner, P. S., Stanfield, J. P., Wright, A. E., Court, S. D. M., and Green, C A. (1960). Brit. med. J., 1, 1077. Higgins, P. G., Boston, D. G., and Ellis, E. M. (1964). Mth. Bull. Minist. Hlth Lab. Serv., 23, 93. Ellis, E. M., and Boston, D. G. (1963). Ibid., 22, 71. Holzel, A., Parker, L., Patterson, W. H., Cartmel, D., White, L. L. R Purdy, R., Thompson, K. M., and Tobin, J. O'H. (1965). Brit. mea. J., 1, 614. Kendall, E. J. C, Bynoe, M. L., and Tyrrell, D. A. J. (1962). Ibid., 2 82 Lidwell, ?. M., and Sommerville, T. (1951). J. Hyg. (Lond.), 49, 365. Peacock, D. B., and Clarke, S. K. R. (1961). Lancet, 2, 466. Sutton, R. N. P. (1962). J. Hyg. (Lond.), 60, 51. Tyrrell, D. A. J. (1963). Amer. Rev. resp. Dis., 88, part 2, p. 77. and Parsons, R. (1960). Lancet, 1, 239.
Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function
Authors: Michael J. White, Simone M. Schoenwaelder, Emma C. Josefsson, Kate E. Jarman, Katya J. Henley, Chloé James, Marlyse A. Debrincat, Shaun P. Jackson, David C. S. Huang, Benjamin T. Kile
Journal: Blood (2012)
A 28-Year-Old Woman With Multiple Moles, 1 Year Later
Authors: Jennifer Daley
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
285. Anti-Tumor Immune Responses Following Neoadjuvant Immunotherapy with a Recombinant Adenovirus Expressing HSP72 to Rodent Tumors
Authors: James A. Krewet, Si-Yi Chen, Maulik R. Shah
Journal: Molecular Therapy (2005)

Gene modification of tumor cells is commonly utilized in various strategies of immunotherapy both as a preventative treatment and a means to modify tumor growth. Gene transfer prior to surgery as neoadjuvant therapy has not been studied systematically. We addressed if direct intra-tumoral injection of a recombinant adenovirus expressing the immunomodulatory molecule heat shock protein 72 (ADHSP72) administered prior to surgery could result in sustainable anti-tumor immune responses capable of affecting tumor progression and survival in a number of different murine and rat tumor models. Using intradermal murine models of melanoma (B16), colorectal carcinoma (CT26), prostate cancer (TrampC2) and a rat model of glioblastoma (9L), tumors were treated with vehicle or GFP expressing adenovirus (ADGFP) or ADHSP72. Tumors were surgically excised after 72 hours. Approximately 25-50% of animals in the ADHSP72 treatment group but not in control groups showed sustained resistance to subsequent tumor challenge. Tumor resistance was associated with development of anti-tumor cellular immune responses. Efficacy of ADHSP72 as neoadjuvant therapy was dependent on the size of the initial tumor with greater likelihood of immune response generation and tumor resistance associated with smaller tumor size at initial treatment. ADHSP72 neoadjuvant therapy resulted in prolonged survival of animals upon re-challenge with autologous tumor cells compared to ADGFP or vehicle control groups. To study the effects on tumor progression of distant metastases, a single tumor focus of animals with multifocal intradermal tumors was treated. ADHSP72 diminished progression of the secondary tumor focus and prolonged survival but only when the secondary tumor focus was <50mm3. Our results indicate that gene modification of tumors prior to surgical intervention may be beneficial to prevent recurrence in specific circumstances.
Fixing chronic stent underexpansion is associated with a low rate of recurrence: An intravascular ultrasound analysis
Authors: Marco T. Castagna, Gary S. Mintz, Jun-Ichi Kotani, Vivek M. Shah, Ellen E. Pinnow, Kenneth M. Kent, William O. Suddath, Ron Waksman, Lowell F. Satler, Chalak O. Berzingi, Augusto D. Pichard, Neil J. Weissman
Journal: Journal of the American College of Cardiology (2003)
The effect of propranolol on canine myocardial CPK distribution space and rate of disappearance.
Authors: J A Cairns, G A Klassen
Journal: Circulation (1977)

Canine myocardial CPK was partially purified and injected into 11 conscious mongreal dogs. From serial serum CPK measurements in each dog, mean Kd was calculated as 0.0047 +/- 0.0009 (+/- SD) min-1. Correlation coefficients indicated that CPK disappearance rate was well described by a single exponential expression. Kd measured on consecutive days in four dogs varied minimally. CPK distribution space ranged from 74 to 134% of plasma volume. Propranolol loading with 0.3 mg/kg or 2 mg/kg, followed by hourly maintenance doses, resulted in increased Kd in eight of ten dogs, mean Kd rising from .0048 min-1 to .0059 min-1 (P less than 0.02). Propranolol appeared to increase plasma volume but had no significant effect on the relationship of CPK distribution space to plasma volume. If the serial CPK technique were used to measure infarct size, using an average Kd, propranolol might produce artifactual reduction of infarct size measuremnt by increasing Kd and possibly by increasing plasma volume. The obligation to assess the effect upon CPK Kd and distribution space of an agent designed to limit infarct size is apparent.
Vascular Purpura Due to Colchicine in a Patient with Gout
Authors: NICHOLAS P. SINALY
Journal: Annals of Internal Medicine (1964)

Case Studies1 March 1964Vascular Purpura Due to Colchicine in a Patient with GoutNICHOLAS P. SINALY, M.D.NICHOLAS P. SINALY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-3-470 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this report is to present a case of purpura occurring in an individual receiving therapeutic doses of colchicine for acute gouty arthritis. Search of the literature from the present to 1920 reveals no report of this occurrence. Indeed, in a recent publication dealing with the clinical pharmacology of colchicine in the treatment of gouty arthritis, no mention is made of this untoward reaction (1).CASE REPORTA 33-year-old physician suddenly developed swelling and slight discomfort over the left elbow with no history of antecedent trauma. Two years previously he had experienced swelling, stiffness, and some discoloration of...References1. WALLACE SL: Colchicine, clinical pharmacology in acute gouty arthritis. Amer. J. Med. 30: 439, 1961. CrossrefMedlineGoogle Scholar2. SEEDSLAUGHTERLIMARZI LDPLR: Effect of colchicine on human carcinoma. Surgery 7: 696, 1940. Google Scholar3. LUDFORD RJ: Colchicine in the experimental chemotherapy of cancer. J. Nat. Cancer Inst. 6: 89, August, 1945 to June, 1946. Google Scholar4. LUDFORD RJ: Factors determining the action of colchicine on tumor growth. Brit. J. Cancer 2: 75, 1948. CrossrefMedlineGoogle Scholar5. BOYLANDBOYLAND EME: Studies in tissue metabolism. IX. The action of colchicine and B. typhosus extract. Biochem. J. 31: 454, 1937. CrossrefMedlineGoogle Scholar6. DUSTINCHODHOWSKI APK: Etude de la cicatrisation par la reaction colchicinique. C. R. Ass. Anat. 32: reprint, pp. 1-7, 1937. Google Scholar7. BROWNSEED WOL: Effect of colchicine on human tissues. Amer. J. Clin. Path. 15: 189, 1945. CrossrefGoogle Scholar8. BAUERKLEMPERER WF: Treatment of gout. New Eng. J. Med.: 231, 681, 1944. CrossrefGoogle Scholar9. FLETCHER E: Medical Disorder of the Locomotor System, 1st Edition, E. and S. Livingstone, Edinburgh, 1947, p. 478. Google Scholar10. MACLEODPHILLIPS JGL: Hypersensitivity to cholchine. Ann. Rheum. Dis. 6: 224, 1947. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, MarylandFrom the Department of Medicine, United States Public Health Service Hospital, Baltimore, Maryland.Requests for reprints should be addressed to Nicholas P. Sinaly, M.D., Department of Medicine, United States Public Health Service Hospital, Wyman Park Drive and 31st Street, Baltimore 11, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1964Volume 60, Issue 3Page: 470-473KeywordsArthritisClinical pharmacologyColchicineElbowGoutHospital medicineInflammationMedical servicesStiffnessVascular medicine Issue Published: 1 March 1964 PDF downloadLoading ...
SOME BACKGROUND FACTORS IN RECENT ENGLISH PSYCHIATRIC PROGRESS
Authors: ARI KIEV
Journal: American Journal of Psychiatry (1963)

The factors outlined herein—a 19th century tradition of moral psychiatry, a history of social legislation, the activities of lay reformers and the development of a nationalised health scheme—have all made significant contributions to the current developments in English psychiatry, characterized by therapeutic communities, open-door hospitals, day centers, industrial rehabilitation units and aftercare programmes. From as early as the 1930's British hospital psychiatry has progressively moved away from a custodial position towards the development of an atmosphere conducive to the development of therapeutic communities and giving effect to procedures conceived in the late 18th century. More and more, attention has been directed towards good hospital-community relations, the betterment of aftercare, and in general the establishment of a preventive psychiatry where patients can be admitted early and treated rapidly. Examination of the factors discussed herein suggests that not only did a fertile soil exist for the growth of these ideas and practices but that an effective machinery for carrying out such programmes has been made available. It is of especial interest that most of these developments were being introduced before the advent of tranquilizers which have been credited for the increasing permissiveness and humanity of hospital policies(45). Much as the developments in the days of Tuke were part of a larger social picture, so too the current changes in medical and psychiatric care are part of an increasingly liberal political and social policy which has provided much social welfare legislation (15). It is suggested that an examination of such factors is necessary in evaluating the development and success of current experiments in psychiatry which have not developed de novo or from some preformulated theoretical position but stem from a long history of social and legislative reform and have been fostered as an aspect of a nationally organised health scheme.
Acetaminophen Sensitivity And Fixed Dermatitis
Authors: Charles C. Henriques
Journal: JAMA (1970)

<h3>To the Editor.—</h3> With the growing awareness of hypersensitivity and various other undesirable side effects from aspirin and other salicylates, there has been increasing utilization of acetaminophen as a simple analgesic and antipyretic agent. Other available substitutes, such as phenacetin and the pyralozones, are used less often because of the frequency and severity of untoward reactions. Acetaminophen in usual dosage may cause drowsiness, methemoglobinemia, and impaired mentation. Overdosage may cause chills, emesis, convulsions, and death from respiratory failure. There have been no published reports of hypersensitivity reactions to acetaminophen, but one manufacturer has nine such reported cases on file. Six of these cases developed pruritic maculopapular rash, one exhibited laryngeal edema and urticaria, and two others developed angioedema and anaphylactoid reactions. All reactions were said to be controlled by "symptomatic medication and withdrawal of the drug." The following case of an apparent fixed drug eruption due to acetaminophen is presented.
Erosive pustular dermatosis of the leg-a definition
Authors: J.A. Cotterill, S.W. Lanigan
Journal: British Journal of Dermatology (2006)

Journal Article Erosive pustular dermatosis of the leg—a definition Get access J.A. Cotterill, J.A. Cotterill Department of Dermatology, The General Infirmary at Leeds, Leeds LS1 3EX Search for other works by this author on: Oxford Academic Google Scholar S.W. Lanigan S.W. Lanigan Bridgend General Hospital, Wales Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 123, Issue 4, 1 October 1990, Page 548, https://doi.org/10.1111/j.1365-2133.1990.tb01465.x Published: 01 October 1990
Progestogen-only oral contraceptives.
Authors: H. J. Cox
Journal: BMJ (1969)

Studies are cited on the use of minidose progestogens for contraception.  A dosage of .5 mg daily of megestrol acetate had proven reasonably effective whereas .25 mg megestrol acetate daily proved ineffective 21 of 43 women in the study becoming pregnant.  Studies showed norethisterone norgestrol and chlormadinone very much more effective.  Preliminary data on a study using .05 mg norgestrol daily are given.  During 800 cycles of medication no pregnancies occurred.  The pill was started on any day of the cycle and could be relied upon from the first day but 4 hours were to be allowed from the time of taking the tablet and coital activity restricted to 14 hours from the time of medication.  The restrictions are gradually relaxed with continued use.  Although the precise mechanism of action of minidose progestogens is not known it seems to have rapid contraceptive effects.  The onset of action and duration of effect are thought to be fairly critical during the early months.
Cough Related to Angiotensin-Converting Enzyme Inhibition
Authors: Joseph V. Levy
Journal: JAMA (1989)

<h3>To the Editor. —</h3> I believe that the conclusions reached by Boulet and colleagues<sup>1</sup>regarding airway responsiveness during 4- to 8-week therapy with captopril require some scrutiny. The authors designed their study to assess airway responsiveness and reactivity in hypertensive patients using a provocative concentration of the cholinergic agonist methacholine. Based on their results, they conclude that the development of cough related to captopril use is not associated with the "development of airway hyperresponsiveness." These conclusions must be interpreted more narrowly since the authors evaluated the reactivity to methacholine only and not other substances and mediators more likely to be implicated as causative factors in cough induced by angiotensin-convertive enzyme (ACE) inhibitors. Specifically, there is experimental and clinical evidence that captopril may prevent the catabolism of bradykinin, a peptide that is a potent bronchoconstrictor, as well as being able to provoke cough that mimics that caused by captopril and
Asymptomatic airway hyperresponsiveness: what does it mean?
Authors: L-P. Boulet
Journal: European Respiratory Journal (2008)

To the Editors: 

I read with interest the study by van den Nieuwenhof et al. 1, which appeared in a recent issue of the European Respiratory Journal . The study’s conclusion is certainly of interest: screening for asymptomatic airway hyperresponsiveness (AHR) in adolescents does not identify subjects at risk of developing asthma, whilst the presence of allergy is a risk factor for asthma. However, the observations leading to this statement should be interpreted with caution.

I agree with the authors that AHR may be variable. It can improve significantly at adolescence, the period associated with the highest incidence of asthma remission. The situation seems different in adults, however.

In some subjects, AHR may reflect a previous “insult” to the airways, either of infectious, toxic or allergic origin, or it could be the consequence …
CELLULAR AND HUMORAL RESPONSE TO TRANSPLANTATION ANTIGENS
Authors: J.-C. Cerottini, A. A. Nordin, K. T. Brunner
Journal: The Journal of Experimental Medicine (1971)

After transfer into heavily-irradiated allogeneic mice, spleen cells were found to produce two types of effector cells directed against the recipient alloantigens, namely alloantibody plaque-forming cells (PFC) and cytotoxic lymphocytes (CL). Both types of effector cells were detectable in vitro by virtue of their lytic effect on target cells carrying the recipient alloantigens. Alloantibody PFC activity was dependent on the presence of an exogenous source of complement and could be inhibited by the addition of heterologous antisera to mouse micro-chain or Fab fragment in the assay system. CL activity was independent of added complement, was not affected by anti-immunoglobulin antisera, but was inhibited by the addition of antibody against target cell alloantigens. Treatment of the transferred spleen cells with anti-theta-serum and complement before in vitro assays for PFC and CL completely abolished the CL activity but had no effect on alloantibody-plaque formation. These results indicate that the two types of effector cells can be differentiated in vitro by virtue of their susceptibility to anti-theta-serum and the mechanisms by which they cause cell lysis.
MALARIA, SEX, AND PLACE OF RESIDENCE AS FACTORS IN ANTIBODY RESPONSE TO EPSTEIN-BARR VIRUS IN GHANA, WEST AFRICA
Authors: RobertJ. Biggar, EvelyneT. Lennette, FrancisK. Nkrumah, Charlotte Gardiner, WilliamE. Collins, Werner Henle
Journal: The Lancet (1981)
Leptin Is Reduced in Lean Subjects With Type 2 Diabetes in Bangladesh
Authors: Mohammed Abu Sayeed, Abul Kalam Azad Khan, Hajera Mahtab, Khandaker Abdul Ahsan, Akhtar Banu, Parvin Akter Khanam, Bo Ahrén
Journal: Diabetes Care (2003)

Although leptin levels are increased in obesity (1), obese subjects with type 2 diabetes display reduced leptin (2–4), which may be due to altered fat distribution (5). This study examined whether leptin levels are also reduced in lean subjects with type 2 diabetes.

Fifty nonobese Bangladeshi women with type 2 diabetes (aged 37.2 ± 1.3 years) were selected randomly from the Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) outpatient department (28 were on diet and exercise, and 22 were on oral hypoglycemic agents; HbA …