Trimethoprim-Sulfamethoxazole and Brain Abscess
Authors: BRUCE M. GREENE
Journal: Annals of Internal Medicine (1975)

Letters1 June 1975Trimethoprim-Sulfamethoxazole and Brain AbscessBRUCE M. GREENE, M.D., FRANK E. THOMAS JR., M.D., ROBERT H. ALFORD, M.D., F.A.C.P.BRUCE M. GREENE, M.D.Search for more papers by this author, FRANK E. THOMAS JR., M.D.Search for more papers by this author, ROBERT H. ALFORD, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-6-812 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWe recently treated a patient with a brain abscess with trimethoprim-sulfamethoxazole (TM-SMX), an antimicrobial combination that is relatively new in this country. We were able to document penetration of the drug into the abscess by measuring levels in pus obtained at craniotomy.This 35-year-old man was found to have bilateral mastoiditis in July 1973 with an air-fluid level in the mastoid bone on the right. He refused surgical intervention until October 1973, when he underwent a right tympanoplasty and mastoidectomy. Postoperatively, drainage from the right ear resumed, which grewProteus mirabilis. Gentamicin and cephalothin therapy was begun in another hospital....References1. SIGEL C and GRACE M: A new fluorescence assay of trimethoprim and metabolites using quantitative thin-layer chromatography. J Chromatogr 80:111-116, 1973 CrossrefMedlineGoogle Scholar2. ROSENBLATT J and STEWART P: Combined activity of sulfamethoxazole, trimethoprim, and polymixin B against gram-negative bacilli. Antimicrob Agents Chemother 6:84-92, 1974 CrossrefMedlineGoogle Scholar3. BLACK P, GRAYBILL J, and CHARACHE P: Penetration of brain abscess by systemically administered antibiotics. J Neurosurg 38:705-709, 1973 CrossrefMedlineGoogle Scholar4. MADERAZO E and QUINTILIANI R: Treatment of nocardial infection with trimethoprim and sulfamethoxazole. Am J Med 57:671-675, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BRUCE M. GREENE, M.D.; FRANK E. THOMASJR., M.D.; ROBERT H. ALFORD, M.D., F.A.C.P.Affiliations: Infectious Disease Section Medical Service Veterans Administration Hospital Vanderbilt University School of Medicine Nashville, Tennessee 37203 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnti-infective treatment of brain abscessCentral Nervous System Infection in the Immunocompromised HostSuccessful Therapy of Postneurosurgical Meningitis Caused by a Resistant Strain of Enterobacter AerogenesCentral Nervous System Infection in the Immunocompromised HostListérioses neuroméningées de l'adulte : Étude rétrospective de 22 casUse of Antibacterial Agents in Infections of the Central Nervous SystemTrimethoprim*LettersCitrobacter Ventriculitis in a Neonate Responsive to Trimethoprim-sulfamethoxazoleTrimethoprim Alone: Clinical UsesCerebral abscessAntibiotic susceptibility and synergy of clinical isolates of Listeria monocytogenesTrimethoprim-sulfamethoxazole therapy of experimental Escherichia coli meningitis in rabbitsInfections of the Central Nervous SystemTrimethoprim-Sulfamethoxazole for MeningitisJOHN A. ROBINSON, M.D. 1 June 1975Volume 82, Issue 6Page: 812-813KeywordsAbscessesAntimicrobialsBoneBrainDrugs ePublished: 1 December 2008 Issue Published: 1 June 1975 PDF downloadLoading ...