tbuckley/cabot-search huggingface dataset:
Clean Out Your Cobwebs and Clean Up Your Block: Walk
Authors: Sheldon B. Cohen
Journal: JAMA (1988)

To the Editor.—  Walking for Health and Fitness 1 and the accompanying editorial Walk With Your Doc 2 are timely reminders of simple techniques that we can use to enhance the health and well-being of our patients.  Like Henry David Thoreau, walking has always been one of my most enjoyable avocations and, also, frequently a more satisfying way of getting from one location to another. I well remember the two-mile walks to and from medical school that helped me clear out the cobwebs and prepare for the day as well as unwind at the end of the day. I'm sure my many classmates who stopped to offer a ride could not fathom my reasons.  Thirty-five years ago, when I began my psychiatric residency in a state hospital, I discovered that many of the chronically psychotic patients were more relaxed and talkative if we walked through the bucolic hospital grounds. I
Correction: Corrigendum: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
Authors: Sonia A Melo, Santiago Ropero, Catia Moutinho, Lauri A Aaltonen, Hiroyuki Yamamoto, George A Calin, Simona Rossi, Agustin F Fernandez, Fatima Carneiro, Carla Oliveira, Bibiana Ferreira, Chang-Gong Liu, Alberto Villanueva, Gabriel Capella, Simo Schwartz, Ramin Shiekhattar, Manel Esteller
Journal: Nature Genetics (2010)
METABOLISM IN DIABETES
Authors: GRAHAM LUSK
Journal: JAMA (1910)

"When Bernard had completed his lectures in the winter term of 1854-55, few questions in physiology were apparently more completely settled than that of the glycogenic function of the liver. The consequences of this doctrine were of the utmost importance, for, once settled that sugar is the product of animal as well as vegetable organisms and that an organ can be found which is singly concerned in its production, we would have at once in the exaggerated performance of a normal function, the proximate cause of diabetes. There had been from the first no lack of opposition to Bernard's views, but so skilfully had he defended his position that, at the time of which we make mention the very objections of his critics had only served to increase, in the eyes of the candid, the magnitude of his triumph." These were the opening words of an article on "The Origin
Voice Problems of Children
Authors: Susan S. Laber
Journal: JAMA (1979)

This book on voice disorders in children is an excellent text. It is beautifully organized, cogently written, and makes liberal use of the Netter drawings. It includes a good glossary, and the references cited are extensive and recent. Wilson advocates a multidisciplinary approach to the treatment of children with voice problems and makes recommendations to help the speech therapist conduct better evaluations. The author acknowledges the difficulty of working with young children to whom the terms "high" and "low" can be confusing. He provides suggestions for visual concomitants that might make the differences in voice pitch meaningful to the children. After differentiating between vocal abuse and vocal misuse, Wilson presents chapters on special areas, eg, velopharyngeal incompetence and hearing loss. Although it is necessary to present these problems in a comprehensive survey of voice disorders, I believe that both these areas require highly specialized expertise for evaluation and treatment. The
RISK OF ADULT T-CELL LEUKAEMIA/LYMPHOMA IN HTLV-I CARRIERS
Authors: Toshifumi Kondo, Hidehisa Kono, Hiroshi Nonaka, Naoaki Miyamoto, Ryouichi Yoshida, Fumihiro Bando, Hiroo Inoue, Isao Miyoshi, Yorio Hinuma, Masao Hanaoka
Journal: The Lancet (1987)
You're never too old
Authors: J Patterson
Journal: BMJ (1994)

My wife and I have recently returned after two years in Pakistan's North West Frontier Province. We have been working for a project which provides a primary health care service to some 25 000 Afghan refugees in three camps not far from Peshawar. We were recruited and placed there by Voluntary Service Overseas (VSO). Nothing new about this; after all VSO has been doing this sort of thing for 30 years and there are now some 20 000 people who have been VSO volunteers. What raised some eyebrows among friends here before we left was that we were then aged 64 and 67.

My wife is a trained teacher and social worker with a lot of administrative experience in both local authority and voluntary organisations. I had been a general practitioner for 20 years and then a medical officer in the civil service. About seven years ago, when we saw retirement approaching and first talked to VSO, the messages were mixed. Our qualifications and experience were welcome, but our age was against us. Because of the attitude of many overseas governments it was difficult to place volunteers of 55 and over. We persevered and were accepted, but when after …
Further Observations on Penicillinase
Authors: Aston B. Greaves
Journal: JAMA (1961)

THE APPLICATION of the enzyme penicillinase (Neutrapen) as a therapeutic agent in the treatment of penicillin reactions has been reassuring to the patient as well as the physician harassed by penicillin reactions. It has been previously demonstrated that parenteral injection of penicillinase in experimental animals and human subjects given penicillin resulted in rapid disappearance of detectable circulating penicillin.<sup>1</sup>However, clinical studies on the therapeutic value of the enzyme are often inconclusive since they frequently rely on improvement of subjective symptoms as their criterion. A more objective clinical analysis of penicillinase may be made by determining spirochetal protection when penicillin and penicillinase are injected concurrently into syphilitic patients with darkfield positive lesions. It was reasoned that if penicillinase destroys all penicillin, then<i>Treponema pallidum</i>will continue to survive in their chancres or moist eruptions. <h3>Materials and Methods</h3> Patients with early syphilitic lesions luxuriant in<i>T. pallidum</i>were selected for this
Maraviroc for Previously Treated Patients with R5 HIV-1 Infection
Authors: Roy M. Gulick, Jacob Lalezari, James Goodrich, Nathan Clumeck, Edwin DeJesus, Andrzej Horban, Jeffrey Nadler, Bonaventura Clotet, Anders Karlsson, Michael Wohlfeiler, John B. Montana, Mary McHale, John Sullivan, Caroline Ridgway, Steve Felstead, Michael W. Dunne, Elna van der Ryst, Howard Mayer
Journal: New England Journal of Medicine (2008)

CC chemokine receptor 5 antagonists are a new class of antiretroviral agents.We conducted two double-blind, placebo-controlled, phase 3 studies--Maraviroc versus Optimized Therapy in Viremic Antiretroviral Treatment-Experienced Patients (MOTIVATE) 1 and MOTIVATE 2--with patients who had R5 human immunodeficiency virus type 1 (HIV-1) only. They had been treated with or had resistance to three antiretroviral-drug classes and had HIV-1 RNA levels of more than 5000 copies per milliliter. The patients were randomly assigned to one of three antiretroviral regimens consisting of maraviroc once daily, maraviroc twice daily, or placebo, each of which included optimized background therapy (OBT) based on treatment history and drug-resistance testing. Safety and efficacy were assessed after 48 weeks.A total of 1049 patients received the randomly assigned study drug; the mean baseline HIV-1 RNA level was 72,400 copies per milliliter, and the median CD4 cell count was 169 per cubic millimeter. At 48 weeks, in both studies, the mean change in HIV-1 RNA from baseline was greater with maraviroc than with placebo: -1.66 and -1.82 log(10) copies per milliliter with the once-daily and twice-daily regimens, respectively, versus -0.80 with placebo in MOTIVATE 1, and -1.72 and -1.87 log(10) copies per milliliter, respectively, versus -0.76 with placebo in MOTIVATE 2. More patients receiving maraviroc once or twice daily had HIV-1 RNA levels of less than 50 copies per milliliter (42% and 47%, respectively, vs. 16% in the placebo group in MOTIVATE 1; 45% in both maraviroc groups vs. 18% in MOTIVATE 2; P<0.001 for both comparisons in each study). The change from baseline in CD4 counts was also greater with maraviroc once or twice daily than with placebo (increases of 113 and 122 per cubic millimeter, respectively, vs. 54 in MOTIVATE 1; increases of 122 and 128 per cubic millimeter, respectively, vs. 69 in MOTIVATE 2; P<0.001 for both comparisons in each study). Frequencies of adverse events were similar among the groups.Maraviroc, as compared with placebo, resulted in significantly greater suppression of HIV-1 and greater increases in CD4 cell counts at 48 weeks in previously treated patients with R5 HIV-1 who were receiving OBT. (ClinicalTrials.gov numbers, NCT00098306 and NCT00098722.)
Noninvasive positive-pressure ventilation in acute respiratory distress without prior chronic respiratory failure.
Authors: W Patrick, K Webster, L Ludwig, D Roberts, P Wiebe, M Younes
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

We evaluated the efficacy of noninvasive mechanical ventilation (NIMV) in alleviating distress and avoiding intubation in patients with de novo acute respiratory failure complicating primary medical disorders. Eleven consecutive patients with severe respiratory distress were entered. In all patients a decision to intubate on an urgent basis had been made, but NIMV could be initiated within minutes. The patients suffered from acute pulmonary edema (five), sepsis/ARDS (two), status asthmaticus (two), and severe pneumonia (two). Dyspnea score (max=10) was (+/- SD) 8.4 +.- 1.6, scale for accessory muscle use (max=5) was 4.2 +/- 0.7, and respiratory rate was 37.6 +/- 3.8 min -1. Pa CO2, pH, and base excess (BE) were 48 +/- 18 mm Hg, 7.27 +/- 0.13, and -5.5 +/- 7.4, respectively, with five patients showing severe metabolic acidosis (BE < - 10). NIMV was applied using proportional assist ventilation. There were three early failures. These included the two patients with sepsis/ARDS who did not tolerate the mask. One patient failed because Pa CO2 and pH deteriorated despite subjective improvement. The remaining eight patients demonstrated progressive improvement, and none required intubation. The duration of NIMV was 3 h to 2 d. We conclude that when NIMV is made available on a "few minutes" basis, selected patients with severe de novo respiratory distress/failure caused by reversible medical disorders, who would otherwise have been intubated, can be given substantial relief and be spared intubation.
Personalized prophylactic anticoagulation decision analysis in patients with membranous nephropathy
Authors: Taewoo Lee, Andrea K. Biddle, Sofia Lionaki, Vimal K. Derebail, Sean J. Barbour, Sameer Tannous, Michelle A. Hladunewich, Yichun Hu, Caroline J. Poulton, Shannon L. Mahoney, J. Charles Jennette, Susan L. Hogan, Ronald J. Falk, Daniel C. Cattran, Heather N. Reich, Patrick H. Nachman
Journal: Kidney International (2013)
Alteration of p73 in acute myelogenous leukemia
Authors: Geeta Ram Sahu, Rajakishore Mishra, Jatin Kumar Nagpal, Bibhu Ranjan Das
Journal: American Journal of Hematology (2005)

The following article from the American Journal of Hematology, "Alteration of p73 in acute myelogenous leukemia" by Geeta Ram Sahu, Rajakishore Mishra, Jatin Kumar Nagpal, and Bibhu Ranjan Das (Am J Hematol 2005;79:1-7; 20284), published online on 22 April 2005 on Wiley Interscience (www.interscience.wiley.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, Carlo Brugnara, and John Wiley & Sons, Ltd. This article described over-expression of p73 in patients carrying mutated p73 genes in adult AML. It has been brought to the attention of the editor that inconsistencies between this manuscript and manuscript "Alteration of p73 in pediatric de novo acute lymphoblastic leukemia" by Sahu GR and Das BR, published in Biochem Biophys Res Commun. 2005 Feb 18;327(3):750-5, cast doubts on the reliability of the data, identity of samples and the reported conclusions. The authors are unable to solve in a timely fashion the discrepancies and overlaps reported for the two data sets and wish to retract the AJH manuscript in toto. They also regret any adverse consequences that may have resulted from the publications of this manuscript. It was also brought to the attention of both editors and authors, that a significant overlap exists between these two papers, which have also been highlighted as potential duplicates in the Deja vu database (see: http://discovery.swmed.edu/dejavu/). The authors express their most sincere apologies and regrets for these overlaps.
Heart Failure in Aortic Stenosis — Improving Diagnosis and Treatment
Authors: Michael R. Zile, William H. Gaasch
Journal: New England Journal of Medicine (2003)

The development of heart failure in patients with aortic stenosis is associated with a high mortality rate — unless aortic-valve replacement is performed. There is an especially high risk of death among patients with aortic stenosis and a decreased ejection fraction. Before surgery is performed in such patients, initial management must include an evaluation of the severity of the stenotic lesion and the functional state of the left ventricle; in addition, the heart failure must be treated and the patient's condition stabilized. It is possible to pursue both of these goals simultaneously with echocardiographic techniques or cardiac catheterization techniques, together . . .
Respiratory reactions provoked by double-blind food challenges in children.
Authors: J M James, J Bernhisel-Broadbent, H A Sampson
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

A total of 320 children with atopic dermatitis undergoing double-blind, placebo-controlled food challenges (DBPCFC) for the evaluation of food hypersensitivity were monitored for respiratory reactions. The patients, ages 6 months to 30 yr, were highly atopic (median IgE; 3,400 IU/ml) and had multiple sensitivities to foods and aeroallergens. Fifty-five percent of the patients had asthma; 45% presented with both asthma and allergic rhinitis. Food hypersensitivity was confirmed by DBPCFC in 205 (64%) of the 320 patients evaluated, and 121 (59%) of these 205 patients experienced respiratory reactions, including nasal, laryngeal, and/or pulmonary symptoms in 34 (17%). To assess the degree of pulmonary dysfunction developing during food hypersensitivity reactions, especially those including lower respiratory symptoms, 88 of these patients were monitored with spirometry during positive and negative DBPCFC. Of these patients, 13 (15%) developed lower respiratory symptoms, including wheezing, during DBPCFC; however, only six patients had a > 20% decrease in FEV1. We conclude that respiratory symptoms are commonly provoked in children with atopic dermatitis during DBPCFC, but significant bronchopulmonary obstruction is not frequently observed.
Use of lignocaine in treatment of cardiac arrhythmias.
Authors: F. H. Spracklen, J. J. Kimerling, E. M. Besterman, J. W. Litchfield
Journal: BMJ (1968)

Oral Lichen Planus-awson MWDi'ICSoui 89 In 30 patients with oral lichen planus regarded as severe enough to justify treatment, use of betamethasone (Betnovate) pellets 0.1 mg. was followed by substantial improvement or complete clearance of oral lesions in 20.Seven patients showed gradual or incomplete improvement.Only 2 out of 30 patients failed to show any response to betamethasone, but treatment was not continued for more than one month in these cases.Of two patients with mucous membrane pemphigoid the use of betamethasone pellets was followed by complete clearance of oral lesions.A third patient showed substantial improvement until he ceased to attend.The only side-effect of treatment was development of thrusb in four patients.The assistance of Messrs. Glaxo in their generous supply of tablets and for other help for this trial is gratefully acknowledged.
Discoloration of Teeth Induced by Tetracycline
Authors: Austin H. Kutscher
Journal: JAMA (1963)

THERE IS SUBSTANTIAL evidence that the teeth of prematurely born children are discolored as the result of tetracycline deposition therein during prophylactic or therapeutic regimens instituted after birth.<sup>1, 2</sup> Detailed clinical studies of patients with cystic fibrosis of the pancreas<sup>3-5</sup>and laboratory studies on animals dosed with tetracycline at various stages during their development have provided additional gross and microscopic evidence of discoloration of teeth induced by tetracycline. Also, much information has appeared in the literature describing the particular affinity and selectivity which tetracycline compounds exhibit for bone and tooth substances. This report describes the case of an infant with discolored deciduous teeth whose mother had received tetracycline during pregnancy. Since the preparation of this manuscript was undertaken two papers have been published which describe discoloration of the deciduous dentition of a child after tetracycline therapy to the mother during the period of gestation. In a brief note, Harcourt
SEROTHERAPY; INOCULATION WITH SERUM IN TYPHOID FEVER.
Authors: ALFRED C. GIRARD
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cyanide spill threatens health in Hungary
Authors: C. Kovac
Journal: BMJ (2000)

<h3>Abstract</h3> <h3>Objective</h3> To explore the experiences of family physicians and respiratory therapists in treating advanced chronic obstructive pulmonary disease (COPD) and their attitudes to the use of opioids for dyspnea in this context. <h3>Design</h3> Qualitative methodology using one-on-one semistructured interviews. <h3>Setting</h3> Southern New Brunswick (St Stephen to Sussex). <h3>Participants</h3> Ten family physicians and 8 respiratory therapists who worked in primary care settings. <h3>Methods</h3> Participant interviews were audiorecorded, transcribed verbatim, coded conceptually, and thematically analyzed using interpretive description. <h3>Main findings</h3> Participants reported that patients with advanced COPD often suffered from inadequate control of their dyspnea in advanced stages and that they saw the potential value of opioids in this context; however, family physicians described discomfort prescribing opioids. Barriers included insufficient knowledge, lack of education and guidelines, and fear of censure. Those with palliative care experience tended to be more comfortable with opioid prescribing. <h3>Conclusion</h3> Findings suggest an important need to address barriers related to more effective treatment of refractory dyspnea in advanced COPD. Further, findings indicate these efforts should focus on effective palliation and innovative educational initiatives, as well as the development, promotion, and uptake of evidence-based practice guidelines related to prescribing opioids for these patients.
Symmetrical Purpura Doesn't Mirror Child Abuse
Authors: Alan Menter
Journal: JAMA (1987)

To the Editor.—  The recent description by Brown and Melinkovich 1 of a case of Schonlein-Henoch purpura that was originally misdiagnosed as suspected child abuse, along with the accompanying color photograph, graphically illustrate an important differential feature that was not mentioned in the article.  The lesions, as illustrated, are absolutely symmetrical on the cheeks, forearms, hand dorsa, thighs, and knees, producing an almost mirror image picture, left and right. The authors correctly point to the difficulty of differentiating Schonlein-Henoch purpura from traumatic skin lesions, ie, as in child abuse cases. However, the finding of perfectly symmetrical skin lesions, as in their illustrated case, must make an exogenous cause highly unlikely.
Consumption Time Is Not Prothrombin Time
Authors: Paul W. Boyles
Journal: JAMA (1964)

<h3>To the Editor:—</h3> The communication by Drs. Dooley and Perlmutter is timely, and illustrates the danger of subdural or intracranial hematomas in patient receiving long-term anticoagulant therapy. A proper respect for the possible danger of therapy, especially in patients with completed cerebrovascular accidents, is indicated. The aggressive approach used by the authors of this paper in treating intracranial bleeding is to be commended. Certain points, however, in the paper need correction: (1) The degree of anticoagulation is not measured by a prothrombin consumption time but rather by the prothrombin time. (2) There are simple clinical methods (namely, the thrombotest or the partial thromboplastin time) for measuring all of the blood clotting factors which are reduced by orally administered coumarin derivatives. (3) Bleeding with a "therapeutic" prothrombin time is a major problem in patients receiving<i>long-term therapy</i>and does not usually occur in patients who are receiving short-term therapy. Patients receiving
Changing Horses In Midstream
Authors: Frederick F. Kortlucke
Journal: JAMA (1967)

To the Editor:—  In your editorial of Nov 7, 1966, entitled On Changing Terminologic Horses, you conclude with the following paragraph:  Tampering with names is a hazardous undertaking. Terminologic horses are best left unchanged in mid-investigational stream.  In your first paragraph you refer to Sir Sharpey-Schafer. This tampering with his proper name would not have pleased him, or any other knight. Would you like to be known as Sir Sharpey?  Sir Edward, as early as 1894, along with Oliver, first described the hormonal effects of the suprarenal gland. He was born Edward Albert Schafer. In grateful recognition to his great teacher Sharpey, he prefixed his name to his own.  I think it is high time we learn the proper terminological address of our British colleagues. After his knighthood in 1913 we address him as Sir Edward.  I had the pleasure of studying under and knowing this great, courageous, and able
Mutation of TNFRSF13B in a child with 22q11 deletion syndrome associated with granulomatous lymphoproliferation
Authors: Michael W. Mather, Hannah Hayhurst, Chris M. Bacon, Theresa S. Cole, Qiang Pan-Hammarström, Siraj Misbah, Andrew R. Gennery
Journal: Journal of Allergy and Clinical Immunology (2014)