tbuckley/cabot-search huggingface dataset:
Appraisal makes for effective revalidation (official)
Authors: R. E Wakeford
Journal: BMJ (2003)

<h3>Objective</h3> This was a post hoc analysis of the Edaravone Phase III Study MCI186-19 (‘Study 19’) to examine the utility of clinical staging systems as end points in clinical trials in amyotrophic lateral sclerosis (ALS). <h3>Methods</h3> Amyotrophic Lateral Sclerosis Functional Rating Scale—Revised item scores from Study 19 were retrospectively mapped to King’s stage and Milano-Torino staging (MiToS) stage. We assessed the percentage of patients who experienced progression in King’s and MiToS stages during Study 19. We also assessed disease progression in subgroups of patients according to baseline King’s stage. <h3>Results</h3> During double-blind treatment, the percentage of patients who experienced a progression in King’s stage was lower for edaravone (42.0%, 95% CI 30.4% to 53.6%) than placebo (55.9%, 95% CI 44.1% to 67.6%). The most pronounced effect was noted among patients who were in stage 1 and was maintained throughout open-label treatment. An analysis of a ≥2-stage progression in MiToS stage showed no difference between treatment arms during double-blind treatment, but during the open-label period, more rapid progression was noted among patients in the placebo–edaravone arm than among those in the edaravone–edaravone arm (log-rank test, p&lt;0.001). <h3>Conclusions</h3> The King’s and MiToS staging systems provided utility in assessing clinical progression in Edaravone Study 19. These findings may support the use of staging systems as end points in ALS clinical trials and to understand the timing of benefit as measured by these scales.
Better mental health services
Authors: N Bouras
Journal: BMJ (1991)

gonorrhoea during the first quarter of this year.As well as indicating unsafe sexual practice, gonorrhoea in women may also be a risk factor for the acquisition of HIV-I (M Laga et al, sixth international conference on AIDS, San Francisco, 1990).Surveillance of gonorrhoea in women may provide both an indication for assessing the potential for spread of HIV-I in the heterosexual community and a measure of safe sexual practice.
Acute non-specific pericarditis. A description of nineteen cases.
Authors: A. Martin
Journal: BMJ (1966)

Plating of Forearm Bones-Griffiths BDIATis 279five dissections out of 30 (Brash, 1955).It is of interest to note that high radial fractures occurred in two of the three cases described.Reduction of such fractures is easier in supination, and stripping of the flexor pollicis longus is less necessary for exposure.Thus conditions are eminently favourable for a traction injury of the nerve.In Case 3 the radial fracture was not high and the paralysis has been permanent.In this case the cause may be different.The cases in this series differ from those with closed forearm fractures described by Warren (1963), in which the flexor digitorum profundus to index was paralysed in addition to the long thumb flexor.This indicates that the nerve trunk was involved, since the anterior interosseous nerve constantly supplies the index segment of the profundus muscle (Seddon, 1954).The pronator quadratus will be paralysed in both types of injury, but there are no clinical means of detecting this. SummaryFour cases of nerve lesions after plating of forearm bones are described.The probable cause of such lesions is discussed.The prognosis generally seems to be fairly good and recovery can be expected in most cases.It is a pleasure to acknowledge the help and advice of Mr. W. Sillar and Professor R. Barnes in the preparation of this paper.
Lead Analysis of House Dust: A Method for the Detection of Another Source of Lead Exposure in Inner City Children
Authors: Jaroslav J. Vostal, Ellen Taves, James W. Sayre, Evan Charney
Journal: Environmental Health Perspectives (1974)

A method has been developed to test the hypothesis that lead-containing house dust is responsible for the elevated levels of lead in blood of inner city children. Dust analyses of smears from the floors, walls, and windowsills in low-income inner city dwellings have shown a median concentration of lead five times as high in suburban homes. It is suggested that lead-containing dust may be one of the most important environmental sources of increased lead exposure in this specific population group.
Reviews and Notes: Geriatrics: The Clinical Care of the Aged Person: An Interdisciplinary Perspective
Authors: Arthur W. Feinberg
Journal: Annals of Internal Medicine (1995)

Literature of Medicine1 January 1995Reviews and Notes: Geriatrics: The Clinical Care of the Aged Person: An Interdisciplinary PerspectiveArthur W. Feinberg, MDArthur W. Feinberg, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-1-199501010-00044 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Clinical Care of the Aged Person: An Interdisciplinary PerspectiveDavid G. Satin, ed. 485 pages. New York: Oxford University Press; 1994. $65.00.One of the time-honored maxims of geriatric medicine is that geriatric care must be multidisciplinary to be effective. Like many such rules, this one is observed too often in words and not often enough in action. The strength of The Clinical Care of the Aged Person is that it lends support to this dictum by describing the actual provision of such care. The book is an outgrowth of a course on geriatrics taught at Harvard University's Division ... Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1995Volume 122, Issue 1Page: 80 Issue Published: 1 January 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Criteria for evaluating potential transplant recipients vary among centers, physicians
Authors: T. Randall
Journal: JAMA (1993)

ADVANCED AGE or a history of noncompliance, cardiovascular disease, or viral hepatitis may disqualify some patients for renal transplantation at some centers, yet a recent study reveals that not all centers look askance at these conditions. Transplantation centers in the United States use a wide range of criteria in evaluating potential recipients, according to a study of the 182 transplant centers that participate in the United Network for Organ Sharing.  Furthermore, transplant physicians differ markedly on these issues, particularly regarding the ethical questions that have assumed such import as the demand for organs continues to rise far beyond the supply.  The transplant-center study was conducted by the Patient Care and Education Committee of the American Society of Transplant Physicians and presented at the society's annual meeting, held last month in Houston, Tex. In general, the investigators found that university-based centers (as opposed to private centers) and centers that perform larger
Inexpensive reform of records
Authors: P. P Carter
Journal: BMJ (1983)

52 units of Monotard insulin (both 80 units).He was converted to 100 unit insulin and given a 1 ml 100 unit click count syringe.This produces an audible click for every subdivision on the syringe-that is, every two units.He was warned repeatedly that he must draw up seven clicks of Actrapid and 26 clicks of Monotard insulin to give the correct dose.He returned to clinic thirsty and polyuric with persistent 2% glycosuria at home and an afternoon random glucose concentration of 13-4 mmol/l (241 mg/100 ml).He had, in fact, been injecting himself with the correct 14 units of Actrapid but only 26 units of Monotard, which he was carefully reading off the syringe with his new glasses.The audible clicks seemed superfluous and he was given standard disposable 1 ml 100 unit insulin syringes instead.It is fortunate that he did not try to inject 52 clicks of insulin.Although the changeover to 100 unit insulin is going well on the whole, it is important that patients are not told that "marks are the same as U100 units."The old diabetes warning cards, designed for use with 40 or 80 unit insulins, which have a column for "marks," should not be issued to diabetics receiving 100 unit insulin who should receive one of the new U100 cards.Partially sighted patients using the click count syringe should be given very careful education followed by observation of insulin measurement at home after changeover.
Inhibition of endogenous nitric oxide synthase potentiates ischemia–reperfusion-induced myocardial apoptosis via a caspase-3 dependent pathway
Authors: Ulrike Weiland, Judith Haendeler, Christian Ihling, Udo Albus, Wolfgang Scholz, Hartmut Ruetten, Andreas M. Zeiher, Stefanie Dimmeler
Journal: Cardiovascular Research (2000)

Objective: Apoptosis of cardiomyocytes may contribute to ischemia–reperfusion injury. The role of nitric oxide (NO) in apoptosis is controversial. Therefore, we investigated the effect of NO synthase inhibition on apoptosis of cardiomyocytes during ischemia and reperfusion and elucidated the underlying mechanisms. Methods and results: Isolated perfused rat hearts (n=6/group) were subjected to ischemia (30 min) and reperfusion (30 min) in the presence or absence of the NO synthase inhibitor NG-mono-methyl-l-arginine. Reperfusion induced cardiomyocyte apoptosis as assessed by immunohistochemistry (TUNEL-staining) and the demonstration of the typical DNA laddering. Apoptosis during reperfusion was associated with the cleavage of caspase-3, the final down-stream executioner caspase, whereas the protein levels of the anti-apoptotic protein Bcl-2 and the pro-apoptotic protein Bax were unchanged. Inhibition of the NO synthase drastically increased ischemia and reperfusion-induced apoptosis of cardiomyocytes. Moreover, the NO synthase inhibitor enhanced the activation of caspase-3, suggesting that NO interferes with the activation of caspases in ischemia–reperfusion. Conclusion: The results of the present study demonstrate that inhibition of endogenous NO synthesis during ischemia and reperfusion leads to an enhanced induction of apoptosis, suggesting that the endogenous NO synthesis protects against apoptotic cell death. Inhibition of NO synthesis thereby activates the caspase cascade, whereas the Bcl-2/Bax protein levels remained unchanged.
Is Calcification of Intracranial Arteries Important and How?
Authors: Marc I. Chimowitz, Louis R. Caplan
Journal: JAMA Neurology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Collapse of a Medical System: The Case of Equatorial Guinea
Authors: RICHARD C. BROWN
Journal: Annals of Internal Medicine (1980)

Abroad1 August 1980Collapse of a Medical System: The Case of Equatorial GuineaRICHARD C. BROWN, M.D.RICHARD C. BROWN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-2-370 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPolitical oppression in Third-World countries has been commonplace in recent decades. Their citizens may suffer not only from the direct effects of a totalitarian regime but also from the secondary effects of compromised social services. One of the most vulnerable services of a country is its system of medical care. The case of Equatorial Guinea shows how a good medical system can be almost completely destroyed by political upheaval.Equatorial Guinea is composed of the province of Rio Muni on the western coast of Africa and several islands in the...References1. . Equatorial Guinea Background Notes. Washington, D.C.: U.S. Government Printing Office (19770210-847 [2398]); 1977:1-4. Google Scholar2. KLINTEBERG R. Equatorial Guinea—Macias Country. Geneva: International University Exchange Fund: 1978:3-24. Google Scholar3. CHIPEAUX F. Guinea Equatorial, la fin d'un delire. Le Monde, 29 August 1979;10755:1. Google Scholar4. RAMONET I. Faillite economic et isolement. Le Monde Diplomatique, December 1978;297:5. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: United States Embassy B. P. 817; Yaounde, Cameroon PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1980Volume 93, Issue 2Page: 370-371 Issue Published: 1 August 1980 PDF DownloadLoading ...
Serratia Osteomyelitis In Sickle Cell Disease
Authors: James Fonk
Journal: JAMA (1971)

To the Editor.—  Although Serratia organisms were formerly considered nonpathogenic, they are now recognized as potential pathogens. 1,2 Several instances of Serratia osteomyelitis, 1,3,4 have been reported. The present account describes the occurrence of osteomyelitis due to Ser ratia organisms in a patient with sickle cell disease.  Report of a Case.—  A 20-year-old Negro college student was admitted to the Milwaukee County General Hospital because of persistent pain in the left thigh and fever. Three months previously he had been admitted to another hospital for complaints of pain in the left thigh and back thought to be secondary to a sickle cell crisis. One month previously he was readmitted to the same hospital for persistent pain in the left thigh. Again this was thought to be related to sickle cell crisis. He had been treated with analgesics, intravenous fluids, and two units of packed red blood cells. At no time
The Clinical Research Enterprise
Authors: Marya D. Zilberberg
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Understanding Rare Adverse Outcomes Following Living Kidney Donation
Authors: John S. Gill, Marcello Tonelli
Journal: JAMA (2014)

A new era in the treatment of patients with end-stage renal disease (ESRD) was heralded by the first successful kidney transplant in 1954—a living donor transplant between identical twins. A 23-year-old man donated his kidney to his brother and survived until the age of 79 years with a solitary kidney.1 Today, kidney transplantation is the treatment of choice for patients with ESRD, and the shortage of transplantable organs is the major issue limiting the field.2 Both living and deceased organ donations are recognized as critical practices to meet the increasing demand for kidney transplants. The availability of a living donor allows for timely transplants and is associated with superior outcomes compared with dialysis or transplants from deceased donors. In developing countries, where chronic dialysis is too expensive for most families (and the infrastructure to support deceased donation is unavailable), living donor transplant is often the most feasible treatment option. In 2011, living donors provided 42.5% of all transplanted kidneys, with more than 31 000 procedures performed in more than 100 countries.3
Comparison of IMG-Dependent and Non—IMG-Dependent Residencies in the National Resident Matching Program
Authors: Michael E. Whitcomb
Journal: JAMA (1996)

To provide insight into the dynamics that determine the pattern of participation of international medical graduates (IMGs) in graduate medical education (GME).Data on IMG-dependent programs (ie., those having at least 50% of first-year positions filled by IMGs) and non-IMG-dependent programs in 6 core specialties (internal medicine, family practice, obstetrics and gynecology, surgery, pediatrics, and psychiatry) were matched with application data from the 1989 and 1995 National Resident Matching Program (NRMP).Participation of IMG-dependent and non-IMG-dependent programs in the 1995 NRMP and the pattern of US medical graduate (USMG) and IMG applications to these programs in 1989 and 1995.Of the 1634 programs in the 6 specialties, 93.5% participated in the 1995 NRMP. The 1165 non-IMG-dependent programs were significantly more likely to participate in the NRMP and were slightly more likely to fill their offered positions than were the 469 IMG-dependent programs. Specifically, IMGs constituted 76% of applicants to IMG-dependent programs and only 14% of applicants to non-IMG-dependent programs. Changes in NRMP data between 1989 and 1995 indicated that the number of IMG applications to IMG-dependent programs increased 88.7%, as did the number of applicants ranked.Persistent differences exist in the mix of USMGs and IMGs applying through the NRMP to IMG-dependent and non-IMG-dependent programs. Over time, programs that enroll large numbers of IMGs are likely to experience an increase in the number and proportion of applications from IMGs and a decrease in the number and proportion of applications from USMGs. If policies are adopted to limit IMG access to GME, IMG-dependent programs may be unable to recruit USMGs unless the total number of GME programs or the quality of existing programs fundamentally changes.
St. Luke, Most Dear Physician
Authors: John F. Conlin
Journal: New England Journal of Medicine (1953)

ST. Luke, one of the four Evangelists and author of the Acts of the Apostles, was a physician. Eusebius,1 who wrote his History of the Church in the fourth century, held St. Luke to have been a native of Antioch, a physician and companion of St. Paul, and separates him from those of the circumcision.The "beloved physician" or "the most dear physician" is one of several of the Saints honored as a patron of physicians. His versatility is reflected in the fact that he is also the patron of painters (and artists), of glassworkers and (with St. Mark) of . . .
Long-term photochemotherapy: histopathological and immunofluorescence observations in 243 patients
Authors: FRITZ GSCHNAIT, KLAUS WOLFF, HERBERT HONIGSMANN, GEORG STINGL, WILHELM BRENNER, ERNA JASCHKE, KLAUS KONRAD
Journal: British Journal of Dermatology (1980)

Skin biopsies of 243 patients treated with photochemotherapy (PUVA) for 1--4 years were examined histologically. Two hundred and six patients were examined retrospectively after total cumulative UV-A doses of 579 . 6 +/- 598 . 0 J/cm2 (mean +/- s.d.). An eosinophilic homogenization and a reduction of elastic fibres at the dermo--epidermal junction, and an increase of dermal macrophages were found as possible abnormalities. However, except for the increase of melanophages there was no statistically significant correlation between the incidence of these changes, the total UV-A dose applied and the skin type of the patients. Neither were such correlations found in thirty-seven patients biopsies twice after 394 . 8 +/- 267 . 6 J/cm2 and 808 . 5 +/- 458 . 9 J/cm2 (mean +/- s.d.), respectively. Studies with direct immunofluorescence techniques revealed no immunoglobulin deposits in PUVA treated skin in fifty-six patients after 469 . 2 +/- 370 . 2 J/cm2; antinuclear antibodies were observed in 4 . 6% of 129 patients after 169 J/cm2 (mean); in 11% of fifty-three patients reexamined after 381 J/cm2 (mean) and in 13 . 6% of twenty-two patients reexamined a second time after 643 J/cm2 (mean). Thirteen out of a total of 572 patients developed a peculiar mottling of skin in areas previously overdosed by PUVA. Subepidermal homogenization and reduction of elastic fibres were found in 45% of the patients, indicating that these changes indeed are a consequence of PUVA. Nuclear and cellular irregularities were found in 45% of the biopsies and 63% showed a disturbed epidermal architecture, but no carcinomas were observed. PUVA-induced mottling was reversible in 31%, partially reversible in 15%, but continued to be present in 54%.
Modified cisplatin, etoposide, and ifosfamide (PEI) salvage therapy for male germ cell tumors: long-term efficacy and safety outcomes
Authors: A. Necchi, N. Nicolai, L. Mariani, D. Raggi, E. Farè, P. Giannatempo, M. Catanzaro, D. Biasoni, T. Torelli, S. Stagni, A. Milani, L. Piva, G. Pizzocaro, A.M. Gianni, R. Salvioni
Journal: Annals of Oncology (2013)
Advancing Telecare for Pain Treatment in Primary Care
Authors: Michael E. Ohl, Gary E. Rosenthal
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal