tbuckley/cabot-search huggingface dataset:
Introductory Address on the Heat of Fever
Authors: W. M. Ord
Journal: BMJ (1885)

GENTLEMEN,-My first and most pleasing duty is to' o you a hearty weicome on our reassembling in this room after the summer recess.My next thought is, I must confess, of how we may tirn the coming session to best use--of how much mutual braii-pi4f#g we may be.capable, to the advantage of all, even of the sufros.But, in logical order, comes before this some looking back upon work already done, particularly the work of the last session.It ia hardly necessary to remind you that the intellectual activity of our liast session was most vigorous, particularly in that part of it whieh *as passed under the able guidance of my large-hearted and ,able 'pre decessor in this office.We may remember particularly whbat ignity was brought to our annual conversazione by the remarkable essay oetOld Age and changes incidental to it, which formed the subedt-mattes of Dr. Humphry's oration.And our financial retrospect ii n nbtea satisfactory.We may congratulate ourselves that we ocpupy ths new rooms free from sense of indebtedness to anyone outpid, the So.ciety.The financial genius of Mr. Goodsall has brought it abbit tbtA all that we owed in respect of the alterations in our buildi*glshould be covered by debentures subscribed for entirely by our Fdko*bi.If we are satisfied with such progress as has been made, we nust be i'in pelled to maintain it; and, in order to facilitate that fre weomuiia.tion of knowledge and thought which is the true object of' socjimtiei such as this, our Council has determined that, in the coming' sessitn a whilome custom, in desuetude for many years, shall be revived.1 Certain evenings will be set apart, as our programme indicates, for purposes of clinical discussion-of discussion of the cases of patients brought here for inspection and examinationi.November' 9th has been chosen as the first evening for use of this kind; but eox Nvember 2nd our meeting .willhave an allied character.Dr. Gowers.kindl.consented to open, on that evening, a discussion on the ClinicaI VaYlue, of the Deep Reflexes.This is a point on which my own ex Jenoe leads me to believe that we can gain most valuable insfr&i6fby comparison of our various observations.I trust that our F'eIXs comb to our aid in large numbers on that evening, and coti utq to some effective determination of the indications which may be dran from these easily observed.signs.Another part of our proceedings, to which we shall all lo6k fdrwsr ¶i with certain anticipation of receiving valuable instructio',' will' found in the Lettsomian Leetures, this year to be delireie4 by Mr.
Evidence-Based Priority Setting for Health Care and Research: Tools to Support Policy in Maternal, Neonatal, and Child Health in Africa
Authors: Igor Rudan, Lydia Kapiriri, Mark Tomlinson, Manuela Balliet, Barney Cohen, Mickey Chopra
Journal: PLoS Medicine (2010)

As part of a series on maternal, neonatal, and child health in sub-Saharan Africa, Igor Rudan and colleagues discuss various priority-setting tools for health care and research that can help develop evidence-based policy.
PHYSIOLOGIC AND CHEMICAL STUDIES FOLLOWING SUCCESSFUL TOTAL GASTRECTOMY FOR CARCINOMA
Authors: WALTMAN WALTERS
Journal: JAMA (1930)

Subtotal gastrectomy for carcinoma of the stomach has established itself as a procedure of relative safety with excellent results for the cure of malignant conditions. The indications for and advisability of total gastrectomy for carcinoma of the stomach, and the postoperative results, present many interesting problems for investigation. Chief among these is the effect of the loss of the acid and chloride normally secreted by the stomach and the explanation of the secondary anemia, which has been reported by W. J. Mayo 1 and by Moynihan 2 as having occurred as long as three years after operation.  At the Mayo Clinic, operations have been classified as instances of total gastrectomy only if no portion of the stomach has been allowed to remain. Those in which even the smallest amount of gastric wall has been allowed to persist have been grouped as instances of subtotal gastrectomy. The reason for this sharp
The Autophagy Regulator Rubicon Is a Feedback Inhibitor of CARD9-Mediated Host Innate Immunity
Authors: Chul-Su Yang, Mary Rodgers, Chan-Ki Min, Jong-Soo Lee, Lara Kingeter, June-Yong Lee, Ambrose Jong, Igor Kramnik, Xin Lin, Jae U. Jung
Journal: Cell Host & Microbe (2012)
The Analogy of Summer Diarrh a and Cholera
Authors: W. Moore
Journal: BMJ (1889)

perfectly benign cases, no matter where the situation of the arti- ficial aperture.Should the presence of pus during eating be offensive, the:antrum could be opened under the inferior turbin- ated bone by means of an ordinary trocar bent to suit the direc- tion of the cavity.There were no symptoms in the case beyond the offensive discharge from the nostril of same side, pointing to disease of the antrum.Nezw Olfactometer for Estimating Degree of Loss of Snell.-Dr. SCANES SPICER exhibited to the Section, on behalf of Dr. ZWAARDEMAKER, of Utrecht, the olfactometer already described and figured in the JOURNAL.1
Changes in the Ballistocardiogram after Exercise in Normal and Abnormal Subjects
Authors: DONALD H. MAKINSON
Journal: Circulation (1950)

Ballistocardiograms were taken before and at intervals after mild exercise. The normal response has been ascertained by a statistical study of results obtained on 40 healthy subjects. The response of patients varies widely; in some the change after exercise is much diminished, but in others the response is abnormally increased. In some the form of the ballistocardiogram, normal at rest, becomes abnormal after exercise, so the exercise test will often bring out abnormalities not detected by observations made at rest. Additional evidence was secured that the ballistocardiogram may become abnormal before the clinical picture of coronary heart disease develops.
Randomized clinical trials in single patients
Authors: D. J. Balestra
Journal: JAMA (1994)

To the Editor.  —Dr Larson and colleagues have performed a valuable service by showing us that single patient, or N=1, trials are successful for the majority of patients and are cost competitive with other conventional services.1The SPT has greater intuitive appeal to active clinicians because the patient serves as his or her own control, each experiment is seminal, and the generalizability of each result becomes moot. For the practitioner faced with an individual patient, perceptions and expectations often displace the mean, the mode, and the odds ratio as operational paradigms.2  Clinicians often worry how factors important for randomized controlled trials (RCTs) such as sample size, exclusion criteria, and randomization affect the usefulness of results for individual patients. Counterinference (the application of the results of large RCTs to an individual patient) is frequently problematic. The application of clinical or experimental knowledge for the individual patient is tempered by
For the Patient's Good: The Restoration of Beneficence in Health Care
Authors: Arthur L. Caplan
Journal: JAMA (1989)

This book is the result of a collaborative effort between a renowned physician and a well-known bioethicist. Their aim in writing the book is made clear early on in the first chapter: "We intend to show... that... acting for the good of the patient and on virtue is more appropriate to the special context of the medical encounter today" (p 3). By "more appropriate" they mean more appropriate than a single-minded allegiance to the principle of autonomy. The central thesis of this difficult, iconoclastic, and challenging book is that bioethicists (most, according to the authors, under the seductive influence of 19th-century devotees of liberalism such as John Stuart Mill) have gotten physicians hooked on the value of autonomy as the ethical be all and end all of physician-patient relationships. Doctors have somehow gotten it into their heads that their only obligation to their patients consists of discerning what it is
Abstract 3243: Dysfunctional of TGF-β signaling via loss of β2SP activates SOX9 and C-MYC via Notch signaling in Barrett's esophageal adenocarcinoma
Authors: Shumei Song, Dipen M. Maru, Sonsoles Piera-Velazquez, John R. Stroehlein, Marta Davila, Lopa Mishra
Journal: Cancer Research (2012)

Abstract Background: Esophageal adenocarcinoma (EA) is often considered to arise from a clonal stem like population of cells, potentially responsible for its poor prognosis. TGF-β and Notch signaling pathways play important roles in regulating self-renewal of stem cells and gastrointestinal carcinogenesis. We have demonstrated loss of TGF-β signaling components and activation of Notch signaling in Barrett's esophageal adenocarcinoma; however, their contributions to EA and the mechanisms of their action remain unclear. Methods: Immunoblotting and immunofluorescence were used to evaluate protein expression and localization. Notch targets Hes-1, SOX9 and C-MYC transcription were assayed using their luciferase reporters and Q-PCR. Functional studies were performed in β2SP wild type and mutant MEFs cells and in EA cell lines genetically engineered to express high or low levels of β2SP. Results: Increased levels of Notch signaling Hes1 and Jagged1 occurred in EA tissues and cell lines, compared to normal tissues. Loss of β2SP in MEFs cells increased Hes1 expression by 40 fold. In addition, SOX9, a target gene of Notch signaling and a documented stem cell marker was highly up-regulated in EA tumor cells and tissues. Expression of SOX9 was increased in the absence of β2SP in MEFs cells by 9 fold. Down-regulation of β2SP in SKTG-4, FLO-1 and BE3 EA cells by lentivirus shRNA led to increased SOX9 expression and enhanced nuclear localization of both active intracellular Notch1 domain (ICN1) and SOX9. Reintroducing β2SP into EA cells with knock down β2SP decreased SOX9 promoter activity by 10 fold. Concomitantly, an increased proportion of stem cells in β2SP knock down cells were identified using stem cell marker OCT3/4, indicating expansion of putative cancer stem cells in the absence of β2SP. Most interestingly, we observed a direct interaction between Smad3 and ICN1 via Smad3 MH1 domain by GST-pull down assays and that loss of β2SP increases the binding of Smad3 with ICN1 and induces Notch targets SOX9 and C-MYC transcription. Conclusions: Our findings suggests that loss of TGF-β signaling adaptor β2SP may switch Smad3 function from tumor suppression to tumor promotion by binding intracellular Notch1 domain (ICN1) and activating Notch signaling. Thereby, a potential therapeutic value for targeted therapy in EA is in the setting of loss of β2SP/TGF-β with active Notch signaling. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3243. doi:1538-7445.AM2012-3243
TCTAP A-043 Comparison of First versus Second Generation Drug-eluting Stents in Unprotected Left Main Coronary Artery Intervention
Authors: Akkala Raghavender Goud, Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Yoonjee Park, Hu Li, Sunki Lee, Ji Bak Kim, Sung Il Im, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2014)
Active or Passive Exposure to Tobacco Smoking and Allergic Rhinitis, Allergic Dermatitis, and Food Allergy in Adults and Children: A Systematic Review and Meta-Analysis
Authors: Jurgita Saulyte, Carlos Regueira, Agustín Montes-Martínez, Polyna Khudyakov, Bahi Takkouche
Journal: PLoS Medicine (2014)

In a systematic review and meta-analysis, Bahi Takkouche and colleagues examine the associations between exposure to tobacco smoke and allergic disorders in children and adults. Please see later in the article for the Editors' Summary
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Authors: Heon Park, Zhaoxia Li, Xuexian O Yang, Seon Hee Chang, Roza Nurieva, Yi-Hong Wang, Ying Wang, Leroy Hood, Zhou Zhu, Qiang Tian, Chen Dong
Journal: Nature Immunology (2005)
p38 MAP kinase modulates liver cell volume through inhibition of membrane Na+ permeability
Authors: Andrew P. Feranchak, Tomas Berl, Juan Capasso, Paul A. Wojtaszek, Jiahuai Han, J. Gregory Fitz
Journal: Journal of Clinical Investigation (2001)

In hepatocytes, Na+ influx through nonselective cation (NSC) channels represents a key point for regulation of cell volume. Under basal conditions, channels are closed, but both physiologic and pathologic stimuli lead to a large increase in Na+ and water influx. Since osmotic stimuli also activate mitogen-activated protein (MAP) kinase pathways, we have examined regulation of Na+ permeability and cell volume by MAP kinases in an HTC liver cell model. Under isotonic conditions, there was constitutive activity of p38 MAP kinase that was selectively inhibited by SB203580. Decreases in cell volume caused by hypertonic exposure had no effect on p38, but increases in cell volume caused by hypotonic exposure increased p38 activity tenfold. Na+ currents were small when cells were in isotonic media but could be increased by inhibiting constitutive p38 MAP kinase, thereby increasing cell volume. To evaluate the potential inhibitory role of p38 more directly, cells were dialyzed with recombinant p38alpha and its upstream activator, MEK-6, which substantially inhibited volume-sensitive currents. These findings indicate that constitutive p38 activity contributes to the low Na+ permeability necessary for maintenance of cell volume, and that recombinant p38 negatively modulates the set point for volume-sensitive channel opening. Thus, functional interactions between p38 MAP kinase and ion channels may represent an important target for modifying volume-sensitive liver functions.
Why Medical Educators May Be Failing at Feedback
Authors: Robert G. Bing-You
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Molecular profiling of myeloid progenitor cells in multi-mutated advanced systemic mastocytosis identifies KIT D816V as a distinct and late event
Authors: M Jawhar, J Schwaab, S Schnittger, K Sotlar, H-P Horny, G Metzgeroth, N Müller, S Schneider, N Naumann, C Walz, T Haferlach, P Valent, W-K Hofmann, N C P Cross, A Fabarius, A Reiter
Journal: Leukemia (2015)
TCT-170 Vascular Injury Influences Drug Transfer and Vessel Healing Following Paclitaxel Coated Balloon Delivery in the Peripheral Arteries of Swine
Authors: Maxwell Afari, Taylor Palmieri, Armando Tellez, Piotr Buszman, Krzysztof Milewski, Yanping Cheng, Seung-Jin Oh, Greg Kaluza, Juan Granada
Journal: Journal of the American College of Cardiology (2012)
Studying a Study and Testing a Test: How to Read the Medical Literature
Authors: Harriet S. Meyer
Journal: JAMA (1982)

This book is the converse of the more numerous basic biostatistics texts extant: the latter begin by teaching statistics and extrapolate to their use in clinical studies. This book begins, as the title suggests, with clinical studies and then describes the statistical methods used in their interpretation. Statistics texts will give one a firmer grounding in methodology, but Riegelman's approach to understanding the strengths and limitations of published studies is eminently pragmatic. Excellent is the book's initial section, "Studying a Study," in which the author deals in turn with sample selection, assessment (defining and collecting results), analysis of results, interpretation, and extrapolation from results. Included are explanations of cohort, case-control, retrospective, and prospective studies and of clinical trials, selection bias, type I and type II error, and the proper inference of causality. A better discussion of these concepts at the level most useful to the reader of medical literature would
Learning to Smoke: Tobacco Use in the West
Authors: R. McMillen
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Regular spaces versus computing with chaos
Authors: Cees van Leeuwen
Journal: Behavioral and Brain Sciences (1998)

The attempt to provide a faithful mapping from distal shape space to proximal state space in terms of a higher order relationship defined over proximal similarity space stumbles on the context sensitivity of higher order relationships. Proportional analogy problems using quadruples of figures illustrate that for a number of interesting perceptual problems, the number of relevant dimensions cannot be reduced.
Subdividing Departments of Medicine
Authors: William B. Hood
Journal: Annals of Internal Medicine (1993)

Letters15 December 1993Subdividing Departments of MedicineWilliam B. Hood Jr., MDWilliam B. Hood Jr., MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-12-199312150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A recent editorial from the Association of Professors of Medicine [1] stated that certain division chiefs of cardiology have had growing interest in separating from departments of medicine. Far from being a minority opinion, this course was favored by 56 (60%) of 93 cardiology division chiefs in a poll we recently did [2]. The reason was that chairs of medicine often expect disproportionate clinical care, teaching, and research responsibilities of cardiologists, on whom they rely heavily for financial support. The lumping of resource needs with those of less active medical subspecialties has led to some friction. In ...References1. Glickman RM, Bennett JC, Nolan JP, Stobo JD, Rubenstein AH, Mufson MA, et al. United we stand. Ann Intern Med. 1993; 118:903-4. Google Scholar2. Zaret BL, Hood WB Jr, O'Rourke RA. Cardiovascular medicine: subspecialty or specialty. Am J Cardiol. 1993; 72:968-70. Google Scholar3. Structure and function of academic divisions of cardiology. Task Force Reports from the Association of Professors of Cardiology. Arch Intern Med. 1993; 153:2305-16. Google Scholar4. Earley LE. Alternative pathways for training the general internist and the medical subspecialist. Ann Intern Med. 1992; 116:1080-3. Google Scholar5. Glickman R, Bennett JC, Nolan J, Rubenstein A, Terwilliger J. Activism in academic internal medicine. Ann Intern Med. 1992; 117:259-60. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDepartments of Medical Specialties: A Solution for the Divergent Missions of Internal Medicine? 15 December 1993Volume 119, Issue 12Page: 1225-1226KeywordsCardiovascular diseasesCardiovascular physiologyMorbidityMortalityPatientsPharmacologyResearch quality assessmentResidencySub-specialty careSurgery Issue Published: 15 December 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Theophylline Concentrations in Asthmatic Patients
Authors: Terance R. Kordash
Journal: JAMA (1977)

To test the efficacy of using a weight-derived formula to determine aminophylline dosages, 50 patients hospitalized for treatment of severe asthma were given intravenous aminophylline infusions at a rate of 0.9 mg/kg/hr to a maximum dosage of 1,500 mg/24 hr. Serum theophylline determinations done 12 to 96 hours after institution of this therapy showed levels greater than 20 mg/liter in 34% of these patients. Reliance on weight-derived formulas can be dangerous. (<i>JAMA</i>238:139-141, 1977)
Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population
Authors: A. Kato, K. Fukai, N. Oiso, N. Hosomi, T. Murakami, M. Ishii
Journal: British Journal of Dermatology (2003)

Summary Background Netherton's syndrome (NS) is an autosomal recessive disorder characterized by trichorrhexis invaginata ('bamboo hair'), congenital ichthyosiform erythroderma and an atopic diathesis. NS has recently been shown to be due to a defect in the SPINK5 gene, encoding LEKTI, a 15‐domain serine protease inhibitor. SPINK5 maps to chromosome 5q31–q32, and has been suggested to be a locus predisposing to atopy in general. Recently, coding polymorphisms in SPINK5 exons 13 and 14 have been reported to be associated with atopy, asthma and atopic dermatitis (AD). Objectives To examine whether these polymorphisms are also associated with AD in Japan. Methods We characterized eight polymorphisms in SPINK5 exons 13 and 14 in 124 Japanese patients with AD and 110 healthy controls. The polymorphisms we examined were IVS12–26C→T, IVS12–10A→G, 1103A→G (Asn368Ser, in exon 13), 1156G→A (Asp386Asn, in exon 13), 1188T→C (His396His, in exon 13), IVS13–50G→A, 1258G→A (Glu420Lys, in exon 14) and IVS14+19G→A. Results We found significant associations between seven of these polymorphisms and AD in Japanese patients. Conclusions This study confirms the previous suggestion of an association between SPINK5 and AD.
OUTCOME OF CATHETER BASED REVASCULARIZATION FOR PERIPHERAL ARTERIAL DISEASE: MULTI VESSEL VS. SINGLE VESSEL INVOLVEMENT
Authors: Malitha Samanthika Hettiarachchi, Anas Alani, Tamam Mohamad, David H. Rustom, Hamza Aurakzai, Adnan kassier, Camelia Arsene, Mahir Elder
Journal: Journal of the American College of Cardiology (2012)