tbuckley/cabot-search huggingface dataset:
Lipid transfer protein sensitization: reactivity profiles and clinical risk assessment in an Italian cohort
Authors: E. Scala, S. J. Till, R. Asero, D. Abeni, E. C. Guerra, L. Pirrotta, R. Paganelli, D. Pomponi, M. Giani, O. De Pità, L. Cecchi
Journal: Allergy (2015)

Nonspecific lipid transfer proteins (nsLTPs) represent a major cause of systemic food allergic reactions in the Mediterranean area. This study investigate hierarchical patterns and cluster relationships of IgE sensitization to different nsLTPs, and the relationship to clinical allergy in a large Italian cohort.A total of 568 nsLTP-positive subjects after IgE ImmunoCAP-ISAC microarray analysis with Ara h 9, Art v 3, Cor a 8, Jug r 3, Pla a 3, Pru p 3 and Tri a 14 allergens were studied. IgE inhibition experiments were carried out with mugwort and plane tree pollen extracts.Eighty-two per cent of nsLTP-positive participants (94% if <6 years old) were Pru p 3(pos) , and 71% were Jug r 3(pos) . Participants who reacted to >5 nsLTPs reported a higher incidence of food-induced systemic reactions. Only Art v 3 and Pla a 3 (mugwort and plane tree nsLTPs, respectively) were associated with respiratory symptoms, and a correlation was observed between sensitization to pollen and plant food nsLTPs, particularly between Pla a 3 and tree nut/peanut nsLTPs. Co-sensitization to Par j 2 and PR-10 or profilin pan-allergens was associated with a lower prior prevalence of severe food-induced reactions. In inhibition assays, plane and mugwort pollen extracts inhibited 50-100% of IgE binding to food nsLTPs in microarrays.Testing IgE reactivity to a panel of nsLTP allergens unveils important associations between nsLTP sensitization profiles and clinical presentation and allows the identification of novel cluster patterns indicating likely cross-reactivities and highlighting potential allergens for nsLTP immunotherapy.
Nonexcitatory cardiac contractility modulation in heart failure: influence of stimulated chamber on hemodynamic and mechanical response
Authors: Carlo Pappone, Salvatore Rosanio, Daniel Burkhoff, Yuval Mika, Gabriele Vicedomini, Monica Tocchi, Vincenzo Santinelli, Itzhak Shemer, David Prutchi, Walid Haddad, Yehuda Snir, Shiomo A. Ben-Haim
Journal: Journal of the American College of Cardiology (2002)
The Neurobiology of Obsessive-Compulsive Disorder
Authors: Judith L. Rapoport
Journal: JAMA (1988)

<h3>SELECTED CASE</h3> AN 18-YEAR-OLD high school girl from a small town in Maine was brought to a psychiatrist by her mother because of her excessive showering and dressing rituals. Showers lasted two hours; it took a half hour to dress. Each act of dressing was counted and had to be repeated precisely 17 times. These behaviors had begun gradually at age 15 years, causing chronic tardiness at school; two months of counseling with the school psychologist was not helpful. When the psychiatrist was consulted, the patient's circle of friends and activities had narrowed, and she was missing school one or two days a week. She had been an outgoing, popular girl, with average grades, who had not previously exhibited unusual concern for neatness, expressed odd thoughts or preoccupations, or presented any behavioral problems of note. When interviewed, she was embarrassed discussing her washing and counting behaviors. She said she "knew
Orally Administered Grass Pollen
Authors: EBBE TAUDORF, BENT WEEKE
Journal: Allergy (1983)

In 1900 it was claimed that oral administration of ragweed could be used for the hyposensitization of hay fever patients. Several uncontrolled trials have been published, all showing an effect of oral hyposensitization. Only one study was controlled and showed no effect of oral hyposensitization. It was decided to undertake controlled clinical trials to determine the safety and effectiveness of orally administered enteric‐coated grass pollen tablets in patients with hay fever. The actual grass pollen dose in the first trial was 30 times the dose that is normally recommended for preseasonal oral pollen hyosensitization using pollen aqueous solution or pollen powder. The safety study will be described here. Twelve young adults with a history of grass pollen hay fever positive skin prick test and positive nasal provocation test with extracts of timothy grass pollen were randomly allocated to one of the treatment groups with four patients in each group taking enteric‐coated Conjuvac Timothy tablets or enteric‐coated Whole Timothy pollen tablets or enteric‐coated placebo tablets. The study was double blind. Preseasonally, the patients received 342,500 PNU and in total they received 4,500,000 PNU during 6 months. The patients receiving active treatment did not have any side effects. No significant changes were shown in the skin and nasal reactivity to grass pollen during the study. Neither were there any changes in timothy‐specific IgE, IgG, total IgE nor histamine liberation from basophils.
Influence of the consumption of fatty Baltic Sea fish on plasma levels of halogenated environmental contaminants in Latvian and Swedish men.
Authors: A Sjödin, L Hagmar, E Klasson-Wehler, J Björk, A Bergman
Journal: Environmental Health Perspectives (2000)

We examined the influence of widely varied consumption of fatty fish from the Baltic Sea and of age on plasma concentrations of polychlorinated biphenyls (PCBs), polychlorobiphenylols (OH-PCBs), 2, 2-bis(4-chlorophenyl)-1,1,1-trichloroethane (4,4'-DDT), 2, 2-bis(4-chlorophenyl)-1,1-dichloroethane (4,4'-DDE), 2,2',4, 4'-tetrabromodiphenyl ether (BDE-47), hexachlorobenzene (HCB), and pentachlorophenol (PCP) in Latvian and Swedish men. Both age and fish consumption were significantly correlated with the concentrations of [sigman]PCB, [sigman]OH-PCB, 4,4'-DDE, 4,4'-DDT, and HCB. In the case of BDE-47, no significant relationship with age was observed, and fish consumption had the largest relative effect on plasma concentrations of this contaminant. This relationship may be a result of exposure to BDE-47 having been more recent than that of PCBs and DDE, or because the half-life of BDE-47 may be shorter than that of PCB and DDE. Latvian men demonstrated higher plasma levels of DDE and DDT but lower levels of [sigman]PCB and PCP than did Swedish men. The corresponding levels of HCB and BDE-47 were similar in both countries. The Spearman's rank correlation coefficient obtained by comparing the level of the metabolite 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107) to the combined levels of its parent compounds, 2,3,3',4, 4'-pentachlorobiphenyl (CB-105) and 2,3',4,4',5-pentachlorobiphenyl (CB-118), was higher than the median correlation coefficient obtained upon comparing the level of this metabolite to all other possible combinations of two PCB levels. No other increased correlation between metabolite and parent PCB concentration was observed.
Use of Nasal Cannula for Detecting Sleep Apneas and Hypopneas in Infants and Children
Authors: Ha Trang, Vivian Leske, Claude Gaultier
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

We evaluated tolerance of nasal cannula (NC) by 14 infants (median age, 2.6 months) and 16 children (median age, 5.5 years) with suspected obstructive sleep apnea syndrome and compared the efficacy of the NC with that of a nasobuccal thermistor in detecting obstructive apneas (OA) and obstructive hypopneas (OH) on polysomnography traces. The relationship between cannula flow and esophageal pressure was assessed in six patients. Time spent with an uninterpretable flow signal was longer when using a cannula than when using a thermistor in infants (p < 0.05) and children (p < 0.01), and it was longer in the younger patients (p < 0.05). Among the 650 OA–OH detected by either method, only 38% were detected by both, and 58% were detected by the cannula and missed by the thermistor, so that the apnea–hypopnea index was higher with cannula than with thermistor in each age group (p < 0.01). More hypopneas than apneas were detected by the cannula and missed by the thermistor (p < 0.001). Out-of-phase thoracic and abdominal motions and/or changes in the end-tidal CO2 signal shape were associated with 86% of OH identified by cannula. In the six patients whose esophageal pressure was measured, all respiratory events identified using a cannula were associated with increased "airway resistance." Thus, the NC is more likely than the thermistor to detect OA and OH in infants and children, and this superiority is particularly marked for hypopneas.
Hepatitis A — The Price of Progress
Authors: Loriana Di Giammarino, Jules L. Dienstag
Journal: New England Journal of Medicine (2005)

Hepatitis A tends to be a self-limited disease without serious sequelae and with a low case fatality rate1; unlike hepatitis B and hepatitis C, hepatitis A is not a cause of chronic liver disease. On the other hand, approximately 1.4 million clinical cases of hepatitis A occur each year worldwide, and in the United States, hepatitis A is a common cause of acute hepatitis and one of the most frequently reported vaccine-preventable diseases,1 responsible for a substantial economic burden on society.2 A seemingly welcome observation has been the recent decline in the incidence of new cases reported yearly in . . .
Effect of Bacteriuria on Renal Concentrating Mechanisms
Authors: ALLAN R. RONALD
Journal: Annals of Internal Medicine (1969)

To examine the relationship between renal and vesical bacteriuria and maximal urinary concentrating ability (Umax), 38 patients with well-documented urinary tract infections were studied by bilateral ureteral catheterizations. Umax was evaluated by the response to 5 units of vasopressin in oil followed by a 36-hr period of fluid deprivation. With this technic, values of Umax below 800 mOsm/kg are considered abnormal. Individuals with infection localized to the bladder (913 mOsm/kg) concentrated significantly better than those with renal infection (771 mOsm/kg). The noninfected side (875 mOsm/kg) in patients with unilateral bacteriuria concentrated better than its infected counterpart (675 mOsm/kg). Seven of 12 patients with renal infection improved their overall concentrating ability by at least 100 mOsm/kg after eradication of bacteriuria. These studies provide information that demonstrates that renal but not bladder bacteriuria is associated with decreased urinary concentrating ability and show that the defect may be reversible with effective antimicrobial therapy.
POST-CONCUSSION STRESS IN ASYMPTOMATIC ATHLETES
Authors: L Mainwaring, A Senthinathan, M Hutchison
Journal: British Journal of Sports Medicine (2014)

Background Post-concussion, the body is “stressed” as it attempts to restore metabolic and psychologic equilibrium. Elevated stress can be evaluated by disrupted cortisol cycling, perturbations in Heart Rate Variability (HRV), and reported mood disturbance and perceived stress. Assessing stress in concussed athletes may be informative for optimal recovery, safe return-to-play (RTP), and subsequent injury prevention. Objective To assess the utility of non-invasive stress measures in monitoring concussion recovery. Design A prospective matched control group design included collection of salivary cortisol, HRV, and two self-report measures: the Profile of Mood States (POMS), and the Perceived Stress Scale (PSS). All measures were taken at three phases of recovery (1. Symptomatic; 2. Asymptomatic; and 3. One-week following RTP). The same protocol was completed by non-injured athletes. Setting Interuniversity sports teams at a single institution. Participants 11 athletes, across seven sports, diagnosed with concussion and 11 matched-athlete controls volunteered for the study. Main outcome measurements Primary outcome measures to test the a-priori hypotheses included: HRV, AM and PM salivary cortisol, Total Mood Disturbance, Depression, Confusion, Fatigue, Vigor, Tension, Anger, and Perceived Stress. Results A series of 2 (Group) × 3 (Phase) repeated measures ANOVAs revealed significant interactions for HRV and emotional disturbance. Although no emotional disturbance or perceived stress was reported in the asymptomatic phase, concussed athletes displayed altered HRV [increased Low Frequency norm (P=.041) and decreased High Frequency norm (P=.041)]. In addition, significant differences between groups were found for AM cortisol levels one week after RTP (P=.019). Conclusions Concussed athletes displayed perturbations in HRV, indicating neuroautonomic dysfunction, despite resolution of symptom and mood disturbance. In addition, low levels of morning cortisol following RTP may be indicative of a lingering physiological stress response. These non-invasive markers may be clinically useful in post-concussive recovery assessment and prevention of subsequent injury.
Fewer Sperm in the Summer
Authors: Peter J. Jnyder
Journal: New England Journal of Medicine (1990)

During the past two decades, we have become increasingly knowledgeable about human spermatogenesis, its physiologic control, methods of altering it, and the pathologic factors that impair it. We remain ignorant, nonetheless, about many factors that influence spermatogenesis. The paper by Levine et al.1 in this issue of the Journal about seasonal variability in sperm production provides interesting new infbrmation on the subject, although many questions still remain unanswered.Spermatogenesis occurs within the seminiferous tubules of the testes. Testosterone is secreted by the Leydig cells, which reside in the interstitium among the tubules, and its secretion is stimulated by luteinizing hormone . . .
Patent Foramen Ovale Is an Important Predictor of Adverse Outcome in Patients With Major Pulmonary Embolism
Authors: Stavros Konstantinides, Annette Geibel, Wolfgang Kasper, Manfred Olschewski, Liane Blümel, Hanjörg Just
Journal: Circulation (1998)

Right-to-left shunt through a patent foramen ovale is frequently diagnosed by contrast echocardiography and can be particularly prominent in the presence of elevated pressures in the right side of the heart. Its prognostic significance in patients with pulmonary thromboembolism, however, is unknown.The present prospective study included 139 consecutive patients with major pulmonary embolism diagnosed on the basis of clinical, echocardiographic, and cardiac catheterization criteria. All patients underwent contrast echocardiography at presentation. The end points of the study were overall mortality and complicated clinical course during the hospital stay defined as death, cerebral or peripheral arterial thromboembolism, major bleeding, or need for endotracheal intubation or cardiopulmonary resuscitation. Patent foramen ovale was diagnosed in 48 patients (35%). These patients had a death rate of 33% as opposed to 14% in patients with a negative echo-contrast examination (P=.015). Logistic regression analysis demonstrated that the only independent predictors of mortality in the study population were a patent foramen ovale (odds ratio [OR], 11.4; P<.001) and arterial hypotension at presentation (OR, 26.3; P<.001). Patients with a patent foramen ovale also had a significantly higher incidence of ischemic stroke (13% versus 2.2%; P=.02) and peripheral arterial embolism (15 versus 0%; P<.001). Overall, the risk of a complicated in-hospital course was 5.2 times higher in this patient group (P<.001).In patients with major pulmonary embolism, echocardiographic detection of a patent foramen ovale signifies a particularly high risk of death and arterial thromboembolic complications.
763 A double-masked study on the need for adjunctive steroid treatment in vernal keratoconjunctivitis patients treated with alomide 0.1% ophthalmic solution or Opticrom 2%
Authors: L TOMAZZOLI, L SCULLICA, C CESPEDES, M IRUZUBIETA, R SANS, A SECCHI
Journal: Journal of Allergy and Clinical Immunology (1996)
THROMBO-ANGIITIS OBLITERANS IN ASSOCIATION WITH SYPHILIS
Authors: R. P. Smith, D. W. Patterson
Journal: BMJ (1927)

As comieparatively few cases of tllrombo-angiitis obliterans htave been reported in this counitry we desire to record the followinig instance.As will b e se-en, the symptoms were ciaracterized by paini, coldness of feet, ischaemia, inter- iitteiit clatidication and erytliromiielalgia, evidence. of tropl)ie distulrbances shlown by ilcereation of leg and gnngrene of toe, and, at a later date, extension of-the disetse to tle other limb.The patienit, who is of Br itish iiationality, is a tailor's cutter, aged 59.Previous to this illness he was always healthy, and he gave iio history of syphilis.The first symptoms were noticed ninie or ten years before he came under observation, when he suffered from paroxysmal pains in the calf of the left leg; at first they came on after standing for some hours at his work, and wer e relieved on resting.Superficial ulcers developed on the anterior aspect of the lower third of both leas a few years later.For the past two years the painhad iniereased in severity; it was
Aminoaciduria: A Discussion of its Mechanism.
Authors: P. D. Doolan
Journal: Annals of Internal Medicine (1962)

s1 April 1962Aminoaciduria: A Discussion of its Mechanism.P. D. Doolan, H. A. Harper, Ph.D.P. D. DoolanSearch for more papers by this author, H. A. Harper, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-697_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrevious studies in this laboratory have shown that in normal human subjects virtually the entire quantity of the amino acids filtered by the glomerulus of the kidney is reabsorbed by the tubules. With infusions of a mixture of free individual amino acids and a consequent increase in the filtered load, both the amounts reabsorbed and excreted are increased. Despite considerable selectivity among the amino acids, the capacity for reabsorption is such that to date no maximal rate of reabsorption (Tm) for any amino acid has been demonstrated in the human. The amounts filtered are therefore prime determinants of the amounts... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: P. D. Doolan; H. A. Harper, Ph.D.Affiliations: San Francisco, Calif. (BS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 697-697KeywordsAmino acidsKidneysResearch laboratories ePublished: 1 December 2008 Issue Published: 1 April 1962 PDF downloadLoading ...
Diffusion tensor and susceptibility-weighted imaging in concussion assessment of national football league players
Authors: Neal Luther, Sumit Niogi, Kenneth Kutner, Scott Rodeo, Teena Shetty, Russell Warren, Leigh Weiss, Ronnie Barnes, Robert Zimmerman, Apostolos Tsiouris, Roger Hartl
Journal: British Journal of Sports Medicine (2013)

Introduction Standard MRI is normal following the vast majority of concussions. Diffusion tensor imaging (DTI) and susceptibility-weighted imaging (SWI) are advanced MRI techniques hypothesized to be more sensitive in detecting subtle evidence of structural brain injury. Using DTI and SWI in National Football League (NFL) players, we aim to elucidate and localise the presence of such injury following concussions. Methods This ongoing prospective study has recruited active NFL players with and without history of concussion within 6 months prior to entry. Neurological and neurocognitive examination, DTI, and SWI were performed on each subject. Blinded neuroradiologists performed radiographic analysis. Fractional anisotropy (FA) values were measured for 11 distinct white matter tracts on DTI. A global FA value was calculated. SWI was utilised to assess for microhemorrhage. Statistical comparisons between players with and without recent concussion, and to civilian controls, were made. Results Seven of eighteen evaluated players to date had a concussion within 6 months of entry. On DTI, of the 11 tracts evaluated, a significant decrease in FA for concussed players was seen in one tract. There was no significant difference in global FA assessment between players with and without recent concussions. Civilian control comparisons are ongoing. SWI was negative in all players. Conclusions To our knowledge this is the largest prospective brain imaging study, and the first utilising DTI and SWI to assess anatomical injury secondary to concussion, in NFL players. Minimal changes have been observed in players with recent concussion. The clinical significance of these findings remains under investigation. Learning Objectives By the conclusion of the session, participants should be able to (1) understand the role of DTI and SWI in the evaluation of mild traumatic brain injury (2) discuss to what degree long-term football play poses risk in terms of structural brain injury. References Concussion, football, MRI, NFL. How will your Research Improve Patient Care There is no reliable objective test to evaluate the severity of brain injury suffered secondary to concussion, and concussion is a growing area of concern in football and other contact sports. This study evaluates to what degree brain injury as detected by highly sensitive MR technologies (DTI and SWI) is suffered by those who have had long-term, high-level participation in football and now play at the professional level. Information from this study could play an important role in establishing neurological risks of football.
Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition
Authors: Neil Johnson, Yu-Chen Li, Zandra E Walton, Katherine A Cheng, Danan Li, Scott J Rodig, Lisa A Moreau, Christine Unitt, Roderick T Bronson, Huw D Thomas, David R Newell, Alan D D'Andrea, Nicola J Curtin, Kwok-Kin Wong, Geoffrey I Shapiro
Journal: Nature Medicine (2011)
Diagnostic value of troponin T for alterations in left ventricular mass and function in dialysis patients
Authors: Francesca Mallamaci, Carmine Zoccali, Saverio Parlongo, Giovanni Tripepi, Francesco A. Benedetto, Sebastiano Cutrupi, Grazia Bonanno, Pasquale Fatuzzo, Francesco Rapisarda, Giuseppe Seminara, Benedetta Stancanelli, Ignazio Bellanuova, Alessando Cataliotti, Lorenzo S. Malatino
Journal: Kidney International (2002)
A Hemodynamic Study of Left Ventricular Aneurysm
Authors: MICHAEL D. KLEIN, MICHAEL V. HERMAN, RICHARD GORLIN, H. Westcott Vayo
Journal: Circulation (1967)

Thirteen patients with left ventricular aneurysm due to coronary heart disease were studied by left heart and coronary sinus catheterization, including cineventriculography and measurement of ventricular mechanics and energetics at rest, and in some subjects, during either isoproterenol infusion or supine leg exercise. Eight patients had an aneurysm estimated to comprise greater than 20% of the left ventricular surface area, associated with increased left ventricular end-diastolic volume and pressure and mean systolic force. Average isometric rate of pressure rise and mean fiber shortening velocity and distance were uniformly decreased. Five patients had an aneurysm, estimated to comprise less than 15% of the left ventricular surface, associated with normal or nearly-normal left ventricular end-diastolic volume and pressure and mean systolic force. Average isometric rate of pressure rise was normal, but fiber shortening velocity and distance were moderately depressed. Stroke output and cardiac output were reduced in both groups. Aneurysms exhibited either paradoxical systolic expansion or apparent lack of motion (akinesis), or both. A theoretical analysis presented indicated that when approximately 20 to 25% of left ventricular area is inactivated by any pathological process, the degree of shortening distance required of the myofiber to maintain stroke volume exceeds physiological limits, and cardiac enlargement (Starling mechanism) must ensue to maintain adequate ejection of blood. The magnitude of the salutary response of isoproterenol coupled with an increase in mechanical efficiency during catecholamine infusion suggested that myocardial catecholamines were depleted with additional aggravation of heart failure in this disease.