tbuckley/cabot-search huggingface dataset:
Lebensproblematik in der Sicht existenzphilosophischer Psychotherapie
Authors: P. Seidmann
Journal: Psychotherapy and Psychosomatics (1967)

Research Articles| February 12 2010 Lebensproblematik in der Sicht existenzphilosophischer Psychotherapie Subject Area: Psychiatry and Psychology P. Seidmann P. Seidmann Zürich Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1967) 15 (6): 388–406. https://doi.org/10.1159/000285906 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation P. Seidmann; Lebensproblematik in der Sicht existenzphilosophischer Psychotherapie. Psychother Psychosom 1 June 1967; 15 (6): 388–406. https://doi.org/10.1159/000285906 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1967Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
NHS sets out route map for sustainable healthcare
Authors: J. Wise
Journal: BMJ (2011)

A route map for sustainable healthcare, launched this week, calls on every person and every organisation within the NHS to be more efficient with their use of resources, which includes energy, carbon, water, and people’s time.

The document was produced by the NHS Sustainable Development Unit in collaboration with the Department of Health, the Department of Energy and Climate Change, the Department for Environment, Food and Rural Affairs, and environmental groups. It builds on the progress already made to reduce carbon emissions since the NHS Carbon Reduction Strategy was published two years ago.

The route map depicts a sustainable NHS where more care and support is offered closer to home, there is increased use of telemedicine and the focus is on prevention rather than acute care. Other ways the NHS …
Indirect evidence for stimulation of nitric oxide release by tumour necrosis factor- in human veins in vivo
Authors: D. Simper, W. M. Strobel, L. Linder, W. E. Haefeli
Journal: Cardiovascular Research (1995)

The detrimental haemodynamic changes observed in septicaemia are generalised vasodilation, arterial hypotension, and hyporesponsiveness to vasopressor compound, all of which could be explained by the release of an endogenous vasodilator. Experimental and clinical evidence suggests that tumour necrosis factor-alpha (TNF) induces the expression of vascular nitric oxide (NO) synthase within hours and that NO released from smooth muscle cells could be involved in the pathogenesis of septic shock. The aim of this study was to investigate the role of NO in the vascular effects of TNF.Using the dorsal hand vein compliance technique, the effect of the NO synthase inhibitor L-NG-monomethyl-arginine (L-NMMA) on alpha 1-adrenergic responsiveness (phenylephrine 1.25-8000 ng/min) was studied after prolonged local venous infusion of TNF (8.7 micrograms in 5 h) in 9 volunteers and in 6 volunteers without previous cytokine exposure.Mean (+/- s.e.) maximum phenylephrine constriction (Emax) was 73 +/- 6% and log dose-rates exerting 50% of Emax (log ED50) were 3.2 +/- 0.09 (geometric mean: 1535 ng/min). Local co-administration of L-NMMA at a dose sufficiently high to block NO formation (3.4 mumol/min) increased venous sensitivity to phenylephrine threefold (log ED50 2.8 +/- 0.1, P < 0.015; geometric mean: 574 ng/min) whereas Emax was similar (73 +/- 5%). In the controls the phenylephrine dose-response relationship remained unaffected by simultaneous administration of L-NMMA.As no basal release of NO occurs in hand veins without previous exposure to TNF these results provide direct evidence for induction of NO formation in the human vasculature and consecutive resistance to alpha-adrenergic venoconstriction. NO might, therefore, be a key mediator of haemodynamic impairment in humans under conditions with known elevations of circulating TNF, such as a septic shock.
RELATION OF THE LIVER AND THE PANCREAS TO INFECTION OF THE GALLBLADDER
Authors: E. S. JUDD
Journal: JAMA (1921)

Cholecystitis is nearly always associated with a certain grade of hepatitis or pancreatitis, or both. The degree of inflammation in the liver and in the pancreas is often so slight that it is recognized with difficulty. Cholecystitis does not always mean that the infection in the liver and pancreas will also be severe. In certain cases, the disease seems farther advanced in the liver or pancreas than in the gallbladder, suggesting that it was primary in the liver or pancreas and secondary in the gallbladder. It is possible that infection may progress in this manner; nevertheless, all the evidence indicates that the infection is primary in the gallbladder. Graham<sup>1</sup>has recently called attention to the intimate association between the gallbladder and the liver through the lymphatics, and has suggested that in certain cases the gallbladder may be infected through the lymphatics from the liver. A study of these lymphatics
Microfabrication‐Compatible Nanoporous Gold Foams as Biomaterials for Drug Delivery
Authors: Erkin Seker, Yevgeny Berdichevsky, Kevin J. Staley, Martin L. Yarmush
Journal: Advanced Healthcare Materials (2012)

Nanoporous gold is a promising material for multi-functional bio-interfaces with its well-characterized surface chemistry, compatibility with conventional micropatterning techniques, electrical conductivity, and high effective surface-area for molecular release. This paper demonstrates its biocompatibility and capability for drug release to modulate cellular response.
Selective Neuronal Targeting in Prion Disease
Authors: Stephen J DeArmond, Henry Sánchez, Fruma Yehiely, Yin Qiu, Anne Ninchak-Casey, Valerie Daggett, Almerian P Camerino, Juliana Cayetano, Mark Rogers, Darlene Groth, Marilyn Torchia, Patrick Tremblay, Michael R Scott, Fred E Cohen, Stanley B Prusiner
Journal: Neuron (1997)
<i>In Utero</i> Exposures, Infant Growth, and DNA Methylation of Repetitive Elements and Developmentally Related Genes in Human Placenta
Authors: Charlotte S. Wilhelm-Benartzi, E. Andres Houseman, Matthew A. Maccani, Graham M. Poage, Devin C. Koestler, Scott M. Langevin, Luc A. Gagne, Carolyn E. Banister, James F. Padbury, Carmen J. Marsit
Journal: Environmental Health Perspectives (2011)

Background: Fetal programming describes the theory linking environmental conditions during embryonic and fetal development with risk of diseases later in life. Environmental insults in utero may lead to changes in epigenetic mechanisms potentially affecting fetal development.Objectives: We examined associations between in utero exposures, infant growth, and methylation of repetitive elements and gene-associated DNA in human term placenta tissue samples.Methods: Placental tissues and associated demographic and clinical data were obtained from subjects delivering at Women and Infants Hospital in Providence, Rhode Island (USA). Methylation levels of long interspersed nuclear element-1 (LINE-1) and the Alu element AluYb8 were determined in 380 placental samples from term deliveries using bisulfite pyrosequencing. Genomewide DNA methylation profiles were obtained in a subset of 184 samples using the Illumina Infinium HumanMethylation27 BeadArray. Multiple linear regression, model-based clustering methods, and gene set enrichment analysis examined the association between birth weight percentile, demographic variables, and repetitive element methylation and gene-associated CpG locus methylation.Results: LINE-1 and AluYb8 methylation levels were found to be significantly positively associated with birth weight percentile (p = 0.01 and p < 0.0001, respectively) and were found to differ significantly among infants exposed to tobacco smoke and alcohol. Increased placental AluYb8 methylation was positively associated with average methylation among CpG loci found in polycomb group target genes; developmentally related transcription factor binding sites were overrepresented for differentially methylated loci associated with both elements.Conclusions: Our results suggest that repetitive element methylation markers, most notably AluYb8 methylation, may be susceptible to epigenetic alterations resulting from the intrauterine environment and play a critical role in mediating placenta function, and may ultimately inform on the developmental basis of health and disease.
CADASIL-an unusual manifestation with prominent cutaneous involvement
Authors: G. Ratzinger, G. Ransmayr, N. Romani, B. Zelger
Journal: British Journal of Dermatology (2005)

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leucencephalopathy (CADASIL) is a rare vascular disorder affecting mainly the central nervous system with transient ischaemic attacks, strokes, psychiatric symptoms and dementia. It is a progressive familial disease owing to mutations in the Notch3 gene. Clinically apparent skin involvement is usually absent. Electron microscopy of seemingly uninvolved skin reveals characteristic granular deposits in the basal lamina of vessels and adnexals. We report on a case of CADASIL with generalized haemorrhagic macules and patches. Typical neurological symptoms as well as classical findings in histopathology and electron microscopy confirmed the diagnosis. Immunofluorescence showed an increased number of vessels with walls markedly thickened by deposits of fibrin, complement and immunoglobulins. This method could serve as an additional method for accurate diagnosis of CADASIL.
ASSOCIATION OF EPICARDIAL ADIPOSE TISSUE WITH PREVALENT AND INCIDENT ATRIAL FIBRILLATION IN THE GENERAL POPULATION: THE HEINZ NIXDORF RECALL STUDY
Authors: Amir A. Mahabadi, Nils Lehmann, Marie H. Berg, Hagen Kälsch, Marcus Bauer, Kaffer Kara, Susanne Moebus, Karl-Heinz Jöckel, Raimund Erbel, Stefan Möhlenkamp
Journal: Journal of the American College of Cardiology (2013)
Health status of Japanese and Taiwanese after exposure to contaminated rice oil.
Authors: Y Masuda
Journal: Environmental Health Perspectives (1985)

Mass poisonings, called yusho and yu-cheng, occurred in western Japan in 1968 and central Taiwan in 1979, respectively. These occurrences were separately caused by ingestion of rice oils contaminated with polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs) and polychlorinated quaterphenyls. The total intakes of PCBs and PCDFs by the patients were calculated to be, on the average, 633 and 3.4 mg for yusho, respectively, and 973 and 3.84 mg for yu-cheng, respectively, similar amounts of the causal agents being ingested in both instances. Increased eye discharge, pigmentation of nails, skin and mucous membrane, acneform eruptions and feeling of weakness were the most notable symptoms for both the poisonings. The PCB concentrations in the blood of patients were 1-30 ppb for yusho and 3-1156 ppb for yu-cheng five years and one year after the outbreaks, respectively. For the yusho patients, the clinical severity was closely related to the total amount of rice oil consumed and to the blood PCB concentration and the gas chromatographic pattern of blood PCBs.
Clinical features of childhood acute myeloid leukaemia with specific gene rearrangements
Authors: E Frascella, R Rondelli, M Pigazzi, C Zampieron, F Fagioli, C Favre, A A Lippi, F Locatelli, M Luciani, G Menna, C Micalizzi, C Rizzari, A M Testi, A Pession, G Basso
Journal: Leukemia (2004)
British Anti-lewisite
Authors: R. A. Peters, J. Bennet, A. J. King, A. B. Carleton, M. Dixon, G. R. Cameron, J. H. Gaddum, F. J. C. Herrald, G. L. M. McElligott, L. N. Owen, L. A. Stocken, D. I. Williams, H. T. Findlay, R. H. S. Thompson
Journal: BMJ (1947)
Abstract LB-217: A universal cancer detection platform which measures telomerase activity from live circulating tumor cells captured on microfilter
Authors: Tong Xu, Bo Lu, Yu-Chong Tai, Amir Goldkorn
Journal: Cancer Research (2010)

Abstract Objective. · Circulating tumor cells (CTCs) quantified in cancer patients’ blood can predict disease outcome and response to therapy. However, the CTC analysis platforms currently used are expensive, labor-intense, operator-dependent, and only applicable to tumors of epithelial origin. To address these limitations, we engineered a universal cancer detection platform which measures telomerase activity from live circulating tumor cells captured on microfilter. Methodology: Microfilters were fabricated from parylene-C by a multi-step Reactive Ion Etching (RIE) technique and then connected to a constant low-pressure fluid delivery system. To optimize slot size and filtration pressure, PC3 prostate cancer cells were stained with live-cell dye (Calcein-AM) and spiked into whole blood. After filtration, the captured cells were counter-stained with dead-cell stain (propidium iodide, PI) and counted to determine capture efficiency, viability, and enrichment. Telomerase activity measurement was accomplished using blood spiked with cancer cell lines as well as actual patient samples. Briefly, 7.5 ml blood samples were depleted of red blood cells by ficoll gradient centrifugation, and the PBMC fraction was resuspended in PBS, captured on microfilter and lysed. Telomerase activity was assayed from the cell lysates using a modified quantitative PCR telomere repeat amplification protocol (qPCR-TRAP). Results: The optimized microfilter platform was capable of cell capture from 7.5 ml of whole blood in under 15 minutes, achieving 80% capture efficiency, 90% cell viability and 1500-fold sample enrichment. Importantly, the captured cells retained normal morphology by scanning electron microscopy and could be readily manipulated, further analyzed, or expanded on- or off-filter. Remarkably, telomerase activity was reliably detected by qPCR-TRAP from as few as 25 cancer cells spiked into 7.5 ml whole blood, as well as from actual CTCs in patient blood samples and even from single cancer cells captured on microfilter. Conclusions: We present a novel cancer biomarker platform capable of assaying telomerase activity in live CTCs captured on microfilter from human blood. This new technology can be used to elucidate the basic biology of cancer dissemination and also applied clinically to improve prognostication, treatment, or even early detection of common malignancies. It is fast and simple yet fully quantitative and applicable to nearly all solid tumor types, making microfilter telomerase analysis a truly universal and highly promising cancer biomarker platform. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-217.
Long-Term Gold Salt Therapy
Authors: MARTIN E. VANCIL
Journal: Annals of Internal Medicine (1974)

Comments1 June 1974Long-Term Gold Salt TherapyMARTIN E. VANCIL, M.D.MARTIN E. VANCIL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-6-779_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The paper by Sigler and associates (Ann Intern Med80:21-26, 1974) is an excellent report of the beneficial effects from long-term gold salt therapy, which retarded progression of bone and cartilage destruction. These investigators described a system of numerical scoring at 3-month intervals to evaluate patients in "16 specific activities" of daily living; however, their results are not discussed. Obviously, the patient and his physician are concerned with his ability to function adequately. It would be interesting to know if improvement (or lack of it) in these 16 specific activities correlated with changes in the other variables... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Syntex Research 3401 Hillview Ave. Palo Alto, California 94304 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1974Volume 80, Issue 6Page: 779-779KeywordsActivities of daily livingBoneCartilageSalts Issue Published: 1 June 1974 PDF DownloadLoading ...
Abstract 19823: AMP-Activated Protein Kinase Limits the Activation of C-jun N Terminal Kinase and Prevents Cardiac Injury During Ischemia-Reperfusion
Authors: Dake Qi, Xiaoyue Hu, Xiaohong Wu, Lawrence Young
Journal: Circulation (2010)

AMP-activated protein kinase (AMPK) limits and c-Jun N terminal kinase (JNK) exacerbates cardiac injury during ischemia-reperfusion. Pharmacological AMPK activators and constitutively-active AMPK attenuate JNK pathway activation in endothelial and cancer cells, but AMPK's effect on heart cell signaling during ischemia-reperfusion is largely unknown. Thus, we investigated the role of AMPK in modulating JNK activation during ischemia (20 min)-reperfusion (0–60 min) in an in vivo mouse model. Ischemia induced by coronary artery occlusion increased AMPK Thr172 phosphorylation three-fold, which persisted for 10 min following reperfusion. JNK was activated following reperfusion and maximal phosphorylation (five-fold) occurred 10 min after reperfusion. The major JNK upstream kinase, MKK4 was fully activated by 5 min of reperfusion. Compared to wild-type (WT), the ischemic-reperfused region from AMPK kinase dead (KD) hearts demonstrated 60% (P<0.05) greater JNK phosphorylation and 100% (P<0.05) increased activati...
RELATIONSHIP OF ACUTE INFECTIONS TO GLOMERULAR NEPHRITIS 1
Authors: W. T. Longcope, D. P. O'Brien, J. McGuire, O. C. Hansen, E. R. Denny
Journal: Journal of Clinical Investigation (1927)

The etiological relationship of infections to the diffuse form of acute and subacute nephritis is a problem which for many years has com- manded attention, but has rarely received more than casuistic study.L6hlein (a) in 1907 described in detail the early lesions of the glomeruli in acute glomerular nephritis, as well as the subsequent changes that took place in the kidney during the subacute and chronic stages of the disease.Since a large proportion of his cases of acute and subacute nephritis occurred in patients suffering from various forms of infection, usually due to streptococci, he concluded that in the vast majority of cases acute glomerular nephritis was the direct result of streptococcus infection.Fahr (1912), somewhat later,pointed out the frequency with which acute glomerular nephritis was preceded or accompanied by infections particularly those due to streptococci, while Volhard and Fahr (1914) state that in their collected cases one quarter of all those nephritides associated with infections followed tonsillitis, and almost three quarters, 125 of 179, were connected with infections of the upper respiratory tract.Of a total of 67 cases of acute diffuse glomerular nephritis, 44 suffered from angina, scarlatina, wound infections or erysipelas.In general most of the statistical evidence that ean be obtained (Hill (1919); Bell and Hartzell (1922); Kuczynski (1919a); Stolz (1925); Blackfan (1926)) tends to confirm the fact that streptococcus infections and especially tonsillitis precede directly or accompany the onset of a considerable number of cases of acute diffuse glomerular nephritis.Infections due to other or-
Immunodominance of seven regions of a major allergen, Cry j 2, of Japanese cedar pollen for T‐cell immunity
Authors: S. Hashiguchi, K. Hino, Y. Taniguchi, M. Kurimoto, K. Fukuda, M. Ohyama, T. Fujiyoshi, S. Sonoda, Y. Nishimura, G. Yamada, K. Sugimura
Journal: Allergy (1996)

The immunodominant regions of the Japanese cedar pollen allergen Cry j 2 for T‐cell immunity were determined with whole peripheral blood lymphocytes (PBL) derived from seven allergic patients and three nonallergic subjects. Cry j 2‐stimulated T‐cell proliferation was inhibited by anti‐HLA‐DR. but not by anti‐HLA‐DQ antibody, indicating that the responding T cells recognized the allergen peptides associated with HLA‐DR molecules. It was found that seven regions of Cry j 2, i.e., regions corresponding to amino acid numbers 1–26, 70–84, 151–167. 187–203, 252–279, 283–314, and 345–362, were immunodominant for T‐cell proliferation. Thus, Cry j 2 bears a limited number of immunodominant regions despite polymorphic features of HLA‐DR in the immune system. This suggests the possibility of molecularly designing Cry j 2 antagonists that could downregulate allergic reactions to Japanese cedar pollen.
A Method of Administering Systemic Penicillin
Authors: H. L. Milles
Journal: BMJ (1945)

THYROID HYPERPLASIA AFTER THIOURAC1L BRICTISH with 6.6 g. of thiouracil daily for 20 days, and was then given a maintenance dose of 0.2 g. daily for a week.She was discharged from hospital feeling very well.Her weight had increased by half a stone in a month, and her B.M.R. had fallen from + 55 to + 8.A mild tachycardia was the only residual sign of her thyrotoxicosis.She was told to continue 'to take 0.2 g. of thiouracil daily, but
Randomized Trial of Oral Cyclophosphamide and Veliparib in High-Grade Serous Ovarian, Primary Peritoneal, or Fallopian Tube Cancers, or <i>BRCA</i>-Mutant Ovarian Cancer
Authors: Shivaani Kummar, Amit M. Oza, Gini F. Fleming, Daniel M. Sullivan, David R. Gandara, Michael J. Naughton, Miguel A. Villalona-Calero, Robert J. Morgan, Peter M. Szabo, Ahrim Youn, Alice P. Chen, Jiuping Ji, Deborah E. Allen, Chih-Jian Lih, Michele G. Mehaffey, William D. Walsh, Paul M. McGregor, Seth M. Steinberg, P. Mickey Williams, Robert J. Kinders, Barbara A. Conley, Richard M. Simon, James H. Doroshow
Journal: Clinical Cancer Research (2015)

Veliparib, a PARP inhibitor, demonstrated clinical activity in combination with oral cyclophosphamide in patients with BRCA-mutant solid tumors in a phase I trial. To define the relative contribution of PARP inhibition to the observed clinical activity, we conducted a randomized phase II trial to determine the response rate of veliparib in combination with cyclophosphamide compared with cyclophosphamide alone in patients with pretreated BRCA-mutant ovarian cancer or in patients with pretreated primary peritoneal, fallopian tube, or high-grade serous ovarian cancers (HGSOC).