tbuckley/cabot-search huggingface dataset:
The Multiple Risk Factor Intervention Trial
Authors: David B. Gordon
Journal: JAMA (1983)

To the Editor.—  In the article entitled Multiple Risk Factor Intervention Trial in the Sept 24 issue ofThe Journal, it was reported that men with mild hypertension treated with thiazide diuretics had a higher death rate because of CHD than patients in the UC group, despite the fact that BPs were kept lower in the SI group. This finding has aroused considerable surprise and concern.  I would like to call attention to a couple of previously published studies that also indicate a possible myocardial infarct mortality-promoting effect of therapy with thiazide diuretics. In 1978, Jones et al, 1 in a retrospective study of 66 patients who died while being treated for high BP, found that almost half of those who had myocardial infarcts were being treated with benzothiadiazide diuretics. In contrast, of those who died of cerebrovascular accident, only one of 11 women was receiving such diuretics (but five
Renal Sympathetic Denervation Reduces Left Ventricular Hypertrophy and Improves Cardiac Function in Patients With Resistant Hypertension
Authors: Mathias C. Brandt, Felix Mahfoud, Sara Reda, Stephan H. Schirmer, Erland Erdmann, Michael Böhm, Uta C. Hoppe
Journal: Journal of the American College of Cardiology (2012)
Chiropractic and Judge Getzendanner's Injunction-Reply
Authors: Carl F. Needles
Journal: JAMA (1988)

In Reply.—  Dr Goodley raises some interesting points in his letter, but I have several bones to pick with him. Despite formidable contributions to the diagnostic and therapeutic armamentarium, chiropractors are not content to portray their activity as a variety of physiotherapy; rather, they tell the public that malalignments of the spine cause pain through neural pathways and that manipulation can improve these as well as some systemic diseases. No less an authority than Judge Getzendanner had to acknowledge that these claims might be invalid. She nevertheless reasons that because some clients feel better after manipulation that chiropractic is therapeutically effective. However, much of this amelioration is likely to be due to suggestion and placebo effect.  A surgical procedure is successful because it corrects distortions in anatomy and physiology that usually have been discerned preoperatively. But success does not depend on the artfulness of the surgeon, it hinges on his
ECT in LSD Psychosis: A Report of Three Cases
Authors: DAVID J. MULLER
Journal: American Journal of Psychiatry (1971)

Three patients with toxic psychosis associated with LSD ingestion responded dramatically to a short series of unilateral ECTs after more conservative measures had been unsuccessful. The conservative measures consisted of medication, psychotherapy, and therapeutic milieu. The author recommends ECT for the "bad trip" from LSD that does not remit rapidly.
Tourism-Acquired Mansonella ozzardi Microfilaremia in a Regular Blood Donor
Authors: Peter F. Weller
Journal: JAMA (1978)

<i>MANSONELLA ozzardi</i>is a human filarial parasite whose distribution is limited to areas of South and Central America and to the West Indies. In the case of other filarial parasites, brief residence in or travel to endemic areas usually does not eventuate in detectable microfilaremia. For example, of more than 10,000 American military personnel with symptomatic evidence of filarial infection with<i>Wuchereria bancrofti</i>while stationed in the Pacific during World War II, fewer than 20 had detectable microfilaremia, and this was usually transient and of low levels.<sup>1</sup>In the case reported here, an asymptomatic man with only brief exposures in endemic areas during Caribbean vacations was found to have persistent<i>M ozzardi</i>microfilaremia. The patient was a regular blood donor, and microfilaremia was initially detected on a blood smear examined at the time of blood donation. <h3>Report of a Case</h3> A healthy 46-year-old man periodically donated blood at a
The Future of Health Care: Military Model? Canadian Cost Cutting?
Authors: Roger E. Miller
Journal: JAMA (1990)

<h3>To the Editor.—</h3> Dr Bronow<sup>1</sup>and the National Organization of Physicians Who Care are properly concerned about the looming changes in physician payment and practice patterns. Many of their fears, though, may not be wholly justified. We need not go as far as Saskatchewan to find an example of a universal-enrollment, managed care system that has served physicians and patients admirably well. The US military medical system provides comprehensive, cradle-to-grave medical care, with no out-of-pocket cost to the patient, to over 9 million people. At a cost of about $1444 per beneficiary,<sup>2</sup>the system is also more cost-efficient by 28% than the US per capita health care cost and is nearly as cost-efficient as the Canadian and German systems.<sup>3</sup>Poor, elderly, and chronically ill patients are all cared for. While staffing fluctuations occasionally lead to temporary curtailment of services in military hospitals, the Department of Defence—sponsored insurance
Systolic Blood Pressure, Diastolic Blood Pressure, and Pulse Pressure: An Evaluation of Their Joint Effect on Mortality
Authors: Roberto Pastor-Barriuso, Jos R. Banegas, Javier Damin, Lawrence J. Appel, Eliseo Guallar
Journal: Annals of Internal Medicine (2003)

Background: The relative importance of blood pressure components (systolic blood pressure, diastolic blood pressure, and pulse pressure) on cardiovascular risk is currently being debated. Many studies, however, are limited by inadequate statistical methods to separate these effects. Objective: To evaluate the joint effect of blood pressure components on all-cause and cardiovascular mortality by using nonparametric and change point models. Design: Prospective cohort study. Setting: 15-year mortality follow-up of participants in the Second National Health and Nutrition Examination Survey. Participants: 7830 white and African-American men and women 30 to 74 years of age, apparently free of cardiovascular disease at baseline. Measurements: Baseline blood pressure, corrected for measurement error. Results: Of the 1588 patients who died, 582 died of cardiovascular disease. Systolic blood pressure was linearly related to all-cause and cardiovascular mortality in younger and elderly participants. The association of diastolic blood pressure with all-cause and cardiovascular mortality was hockey stickshaped (flat then increasing) in younger participants and J-shaped in elderly participants. Increased pulse pressure was associated with increased risk, decreased risk, or no change in risk depending on age and systolic and diastolic blood pressure. Conclusions: On the basis of these and previous data, the evidence for a monotonic association of systolic blood pressure with all-cause and cardiovascular mortality is compelling, but a J-shaped association for diastolic blood pressure may develop at older age. The complexity of the association of pulse pressure with mortality discourages its use for prognostic or therapeutic decisions.
Escherichia coli Transport by Dalkon Shield String
Authors: K. Paul Katayama
Journal: JAMA (1975)

<h3>To the Editor.—</h3> It is important that the clinician understand exactly what in vitro experiments have proved concerning Dalkon Shield and pelvic inflammatory disease. Tatum et al (231:711, 1975) state that "the unique characteristic of the Dalkon tail theoretically could provide a mechanism whereby pathogenic bacteria from the vagina enter the uterine cavity and cause sepsis." Yet, their own well-done in vitro experiment does<i>not</i>show the transport of<i>Escherichia coli</i>from the distal end of the Dalkon tail (normally located in the vagina) to the proximal end of the tail (which, with the device, is normally located inside the uterus). Hence, their research did not demonstrate a mechanism for the transport of bacteria from the extrauterine to the intrauterine environment. My own research supports the finding of Tatum et al, ie, that<i>E coli</i>were not transported from one end of the tail to the other. Their experiment was
Folic acid deficiency: Main etiological factor of megaloblastic anemia in Kazakhstan?
Authors: Ainur Akilzhanova, Noboru Takamura, Kiyoshi Aoyagi, Ludmila Karazhanova, Shunichi Yamashita
Journal: American Journal of Hematology (2006)

Induction Chemotherapy and Post-Remission Imatinib Therapy for de Novo BCR-ABL-Positive AMLTo the Editor: Translocation t(9;22)(q34;q11) is found in 1-2% of newly diagnosed patients with de novo AML.The prognosis of Ph þ AML is very poor with a median survival time of only 7 months.We present two patients with de novo Ph þ AML who received induction chemotherapy and post-remission imatinib therapy.A 73-year-old man was admitted in November 2003 with fatigue and palpitation.Physical examination showed only pallor.The Hb was 83 g/L, platelets 145 Â 10 9 /L, and WBC 1.4 Â 10 9 /L, 0.12 Â 10 9 /L blast cells.FACS analysis of marrow mononuclear cells showed 22% blast cells positive for HLA-DR, CD34, CD117, CD13, CD33, MPO, and CD38 and partially CD11b.Karyotype analysis of bone
IMPACT OF PERIPROCEDURAL GLYCOPROTEIN IIBIIIA RECEPTOR INHIBITORS ON TIMI FLOW AND 1 MONTH MAJOR CLINICAL OUTCOMES FOLLOWING PRIMARY PERCUTANEOUS CORONARY INTERVENTION IN DIABETIC PATIENTS
Authors: Akkala Goud, Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Yoonjee Park, Sunki Lee, Kim Ji Bak, Sung Il Im, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong-Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2014)
Is needle biopsy of the liver necessary to diagnose HCC ? Reply
Authors: F Cetta, M Zuckermann, A De Nisi
Journal: Gut (2001)

Editor,—Schotman and colleagues (Gut1999;>45:626–7[OpenUrl][1][PubMed][2][Web of Science][3]) reported a patient with subcutaneous seeding of hepatocellular carcinoma (HCC) after percutaneous needle biopsy together with a review of 14 similar cases and correctly outlined the necessity for a critical evaluation of the role of needle biopsy in resectable HCC.1-4 We agree with their conclusion, namely that: (i) a needle biopsy may be indicated only if it is not possible to diagnose HCC by other means (namely increased α fetoprotein (AFP) concentrations, spiral computed tomography (CT), magnetic resonance imaging); in these cases, a single pass with a large needle (18 gauge) may be preferable to multiple passes with smaller calibre needles; (ii) needle … [1]: {openurl}?query=rft.jtitle%253DLiver%2Btransplantation%2B%253A%2B%2Bofficial%2Bpublication%2Bof%2Bthe%2BAmerican%2BAssociation%2Bfor%2Bthe%2BStudy%2Bof%2BLiver%2BDiseases%2Band%2Bthe%2BInternational%2BLiver%2BTransplantation%2BSociety%26rft.stitle%253DLiver%2BTranspl%26rft.aulast%253DTakamori%26rft.auinit1%253DR.%26rft.volume%253D6%26rft.issue%253D1%26rft.spage%253D67%26rft.epage%253D72%26rft.atitle%253DNeedle-tract%2Bimplantation%2Bfrom%2Bhepatocellular%2Bcancer%253A%2Bis%2Bneedle%2Bbiopsy%2Bof%2Bthe%2Bliver%2Balways%2Bnecessary%253F%26rft_id%253Dinfo%253Apmid%252F10648580%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10648580&link_type=MED&atom=%2Fgutjnl%2F48%2F3%2F440.1.atom [3]: /lookup/external-ref?access_num=000085673100009&link_type=ISI
Purification and characterization of an 18-kd allergen of birch (Betula verrucosa) pollen: Identification as a cyclophilin
Authors: P. Cadot, J.F. Díaz, P. Proost, J. Van Damme, Y. Engelborghs, E.A.M. Stevens, J.L. Ceuppens
Journal: Journal of Allergy and Clinical Immunology (2000)
SAT0003 Relationship Between Anticitrullinated Protein Antibodies and Clinical Remission in Arthritis
Authors: R. Hernandez, P. Gonzalez, A. Muñoz, J. L. Marenco
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The relationship between anticitrullinated protein antibodies (ACPA) and the clinical outcome of rheumatoid arthritis (RA) under treatment has been evaluated in clinical trials with conflicting results. Thus, an analysis of the BeSt study(1) indicated that response to treatment was similar in ACPA-positive and ACPA-negative patients However, ACPA-positive patients showed more frequently radiological damage progression. On the contrary, in the IMPROVED study(2), ACPA-negative patients achieved less remissions on treatment than ACPA-positive patients <h3>Objectives</h3> We evaluated the clinical response of patients with RA receiving treatment according to ACPA titers. <h3>Methods</h3> This was a retrospective longitudinal observational study. We included all patients seen at our Unit who fulfilled the following criteria: 1) Diagnosis of RA by a rheumatologist meeting the 1987 criteria for RA; 2) Available determinations of ACPA; 3) Treatment for AR (whether or not biological therapy) with a minimum follow up of 6 months. The outcome variable was clinical regression defined as reaching DAS28 &lt;=2.6. Predictors of the outcome variable were evaluated using logistic regression models adjusted by gender and age. <h3>Results</h3> 71 patients were included, 79% of them women. Clinical regression was observed in 42 (59%) patients during the first 12 months of follow-up. Baseline median (IQR) ACPA levels were 363 (27.7-500) for individuals without clinical regression and 91.7 (7-458) for those with regression (p=0.045). 19 (66%) patients without regression vs. 15 (36%) with regression showed ACPA levels ≥200 (p=0.013). 6 (20%) patients without clinical response vs. 18 (42%) individuals with response showed negative ACPA titers (p= 0.050). Factors independently associated with clinical regression were: Recent onset RA [adjusted odds ratio (AOR) 5; 95% confidence interval (95%CI) 1.01-25; p=0.049], baseline ACPA levels ≥200 [AOR 0.13; 95%CI 0.03-0.5; p=0.004], baseline CRP levels [per unit increase; AOR 0.94; 95%CI 0.91-0.99; p=0.024], baseline DAS28 [per unit increase; AOR 0.47; 95%CI 0.25-0.89; p=0.021]. <h3>Conclusions</h3> ACPA levels can predict clinical regression of patients with RA receiving treatment in real life conditions. Individuals with high ACPA levels may benefit from a more aggressive treatment approach. ACPA titers may be useful to monitor the clinical activity of RA. <h3>References</h3> <i>The association of treatment response and joint damage with ACPA-status in recent-onset RA: a subanalysis of the 8-year follow-up of the BeSt study. M van den Broek,1 L Dirven,1 NB Klarenbeek,1 THE Molenaar,2 Ann Rehum Dis 2012;71:245-248.</i> <i>Remission induction therapy with MTX and predinisone in patients with early rheumatoid and indifferentiated arthritis (yhe IMPROVED study)Ann Rheum Rheum Dis 2012 ;March 8</i> <h3>Disclosure of Interest</h3> None Declared
P1022 QUANTIFICATION OF FIBROSIS IN CHRONIC HEPATITIS C: PERFORMANCE OF TRANSIENT ELASTOGRAPHY AND ACOUSTIC RADIATION FORCE IMPULSE USING COLLAGEN PROPORTIONATE AREA AS REFERENCE
Authors: V. Calvaruso, V. Di Marco, F. Bronte, M.G. Bavetta, N. Alessi, C. Cammà, A. Craxì
Journal: Journal of Hepatology (2014)
Laboratory Diagnosis in the Problem of Suspected Gonococcal Infection
Authors: Nicholas B. Riccardi
Journal: JAMA (1979)

Proper laboratory techniques are indispensable for the diagnosis and detection of gonorrhea. While the smear is efficacious in diagnosing symptomatic urethral gonorrhea in men, it is not reliable for cervical, rectal, pharyngeal, or asymptomatic urethral infection. We have seen the development of four systems of culturing geared toward the office practitioner or where a complete laboratory is not available. They are as follows: Transgrow (transport), Neigon JEMBEC (transport or nontransport), Isocult, and Microcult systems. The Neigon JEMBEC system offers a good choice for the office practitioner. The use of proper diagnostic and culturing techniques and routine screening should bring about an increase in the amount of gonorrhea detected, treated, and subsequently removed from the reservoir of infection.
Increasing BMI was associated with increasing risk for overall cancer incidence and mortality in middle-aged women
Authors: Anna Peeters
Journal: Annals of Internal Medicine (2008)

ACP Journal Club20 May 2008Increasing BMI was associated with increasing risk for overall cancer incidence and mortality in middle-aged womenAnna Peeters, PhDAnna Peeters, PhDMonash University, Melbourne, Victoria, Australia (A.P.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-10-200805200-02013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationReeves GK, Pirie K, Beral V, et al. Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study. BMJ. 2007;335:1134. https://pubmed.ncbi.nlm.nih.gov/17986716Clinical Impact RatingsGIM/FP/GP: Endocrinology: Oncology: References1 Villareal DT, Apovian CM, Kushner RF, et al. Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Obes Res. 2005;13:1849-63. [PMID: 16339115] Google Scholar2 Janssen I, Mark AE. Elevated body mass index and mortality risk in the elderly. Obes Rev. 2007;8:41-59. [PMID: 17212795] Google Scholar Author, Article, and Disclosure InformationAffiliations: Monash University, Melbourne, Victoria, Australia (A.P.)This article was published at Annals.org on 6 May 2008. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe combination of low midarm muscle circumference and high waist circumference predicted higher mortality in older men Anna Peeters BMI and cardiorespiratory fitness predicted mortality in older adults Anna Peeters Metrics 20 May 2008Volume 148, Issue 10Page: JC3-13KeywordsBody mass indexCohort studiesEsophageal cancerMortalityMusclesObesityOverweightPopulation statisticsRenal cancerSmall cell lung cancer ePublished: 20 May 2008 Issue Published: 20 May 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Observers voice concerns about trial of herbal remedy in Cambodian opiate addicts
Authors: J. Parry
Journal: BMJ (2009)

International organisations working in Cambodia have expressed concern over the introduction of an untested and unregistered treatment for opiate addiction that is being promoted in the country.

The herbal remedy, Bong Sen, is manufactured by a private Vietnamese company, Ben Tre Fataco General Import-Export and Trading Service Co, and sold under the brand name Lotus. The company claims that Bong Sen can lead to detoxification of opiate addicts in four to five days.

“The drug has not been approved by the WHO,” said Dr Nafis Sadik, UN Special Envoy on HIV/AIDS in Asia and Pacific. “No information exists on the efficacy of the medicine for drug detoxification. Bong Sen has not been registered by the Ministry of Health for use in Cambodia and there has been no ethics review or data on how the research is being done there.’’ 

According to information obtained …
Distinct Neural Stem Cell Populations Give Rise to Disparate Brain Tumors in Response to N-MYC
Authors: Fredrik J. Swartling, Vasil Savov, Anders I. Persson, Justin Chen, Christopher S. Hackett, Paul A. Northcott, Matthew R. Grimmer, Jasmine Lau, Louis Chesler, Arie Perry, Joanna J. Phillips, Michael D. Taylor, William A. Weiss
Journal: Cancer Cell (2012)
Fats, Oil, Health-Reply
Authors: Maurizio Trevisan
Journal: JAMA (1990)

<h3>In Reply. —</h3> Drs Ullmann and Connor conclude that the approximate nature of the measurements used in our study greatly weakens the conclusions. As we discuss in the article, we are fully aware of the limitations of our measurement of intake; however, this would increase the probability of type II error (ie, falsenegative results) and bias the observed association toward the null. Inaccurate measurement would not, of course, increase the observed strength of the findings.<sup>1</sup>We believe that the main reason such a "crude" measurement instrument is effective is that there is a very large variability among dietary patterns in Italy.<sup>2</sup>Ullmann and Connor dismiss as trivial the observed difference in serum cholesterol level (0.15 mmol/L) between the low- and high-consumption categories of olive oil. This group difference expressed in milligrams per deciliter is 5.8 (216.6 mg/dL for low consumers and 210.8 mg/dL for high consumers in men);
Alcohol-Related Injury Death and Alcohol Availability in Remote Alaska
Authors: Michael G. Landen
Journal: JAMA (1997)

Injury is a major public health problem in Alaska, and alcohol consumption and injury death are associated.To determine the association between injury death, particularly alcohol-related injury death, and alcohol availability in remote Alaska.Survey using death certificate data and medical examiner records to compare mortality rates for total injury and alcohol-related injury during 1990 through 1993 among Alaskans aged 15 years and older who had resided in remote villages of fewer than 1000 persons.Rate ratios of injury death among residents of wet villages (ie, those without a restrictive alcohol law) as compared with injury death among residents of dry villages (ie, those with laws that prohibited the sale and importation of alcohol).Of 302 injury deaths, blood alcohol concentrations (BACs) were available for 200 deaths (66.2%). Of these, 130 (65.0%) had a BAC greater than or equal to 17 mmol/L (> or =80 mg/dL) and were, therefore, classified as alcohol related. The total injury mortality rate was greater among Alaska Natives from wet villages (rate ratio [RR],1.6; 95% confidence interval [CI], 1.3-2.1), whereas this difference was not present for nonnatives (RR, 1.1; 95% CI, 0.3-3.8). For Alaska Natives, the alcohol-related injury mortality rate was greater among residents of wet villages (RR, 2.7; 95% CI, 1.9-3.8) than among residents of dry villages. The strength of this association was greatest for deaths due to motor vehicle injury, homicide, and hypothermia.Although insufficient data existed to adjust for the effects of all potential confounders, residence in a wet village was associated with alcohol-related injury death among Alaska Native residents of remote Alaska villages. These findings indicate that measures limiting access to alcoholic beverages in this region may decrease alcohol-related injury deaths.