Reversal of Haloperidol-Induced Cardiac Arrest by Using Lipid Emulsion
Authors: Guy L. Weinberg, Guido Di Gregorio, David Hiller, Agnes Hewett, Archie Sirianni
Journal: Annals of Internal Medicine (2009)

Letters19 May 2009Reversal of Haloperidol-Induced Cardiac Arrest by Using Lipid EmulsionGuy Weinberg, MD, Guido Di Gregorio, MD, David Hiller, MD, Agnes Hewett, MD, and Archie Sirianni, MDGuy Weinberg, MDFrom University of Illinois at Chicago College of Medicine, Chicago, IL 60612, and Riddle Memorial Hospital, Media, PA 19063., Guido Di Gregorio, MDFrom University of Illinois at Chicago College of Medicine, Chicago, IL 60612, and Riddle Memorial Hospital, Media, PA 19063., David Hiller, MDFrom University of Illinois at Chicago College of Medicine, Chicago, IL 60612, and Riddle Memorial Hospital, Media, PA 19063., Agnes Hewett, MDFrom University of Illinois at Chicago College of Medicine, Chicago, IL 60612, and Riddle Memorial Hospital, Media, PA 19063., and Archie Sirianni, MDFrom University of Illinois at Chicago College of Medicine, Chicago, IL 60612, and Riddle Memorial Hospital, Media, PA 19063.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-10-200905190-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Infusion of lipid emulsion has been reported to be an effective way to treat local anesthetic–induced cardiac toxicity, and recent reports suggest that it might also be effective in other forms of drug-related cardiac arrest (1).Objective: To report a case of successful resuscitation of a patient with haloperidol-induced cardiac arrest after lipid emulsion infusion.Case Report: A 45-year-old woman came to the hospital reporting palpitations and chest pain. Her medical history included untreated hypertension, anxiety, depression, opioid abuse, and cigarette smoking. She was extremely agitated. Her heart rate was 64 beats/min, respiratory rate was 30 breaths/min, and blood ...References1. Picard J, Harrop-Griffiths W. Lipid emulsion to treat drug overdose: past, present and future [Editorial]. Anaesthesia. 2009;64:119-21. [PMID: 19143685] CrossrefMedlineGoogle Scholar2. Straus SM, Bleumink GS, Dieleman JP, van der Lei J, 't Jong GW, Kingma JH, et al. Antipsychotics and the risk of sudden cardiac death. Arch Intern Med. 2004;164:1293-7. [PMID: 15226162] CrossrefMedlineGoogle Scholar3. Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med. 2004;350:1013-22. [PMID: 14999113] CrossrefMedlineGoogle Scholar4. Weinberg G, Ripper R, Feinstein DL, Hoffman W. Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med. 2003;28:198-202. [PMID: 12772136] CrossrefMedlineGoogle Scholar5. Harvey M, Cave G. Intralipid outperforms sodium bicarbonate in a rabbit model of clomipramine toxicity. Ann Emerg Med. 2007;49:178-85, 185. [PMID: 17098328] CrossrefMedlineGoogle Scholar6. Bania TC, Chu J, Perez E, Su M, Hahn IH. Hemodynamic effects of intravenous fat emulsion in an animal model of severe verapamil toxicity resuscitated with atropine, calcium, and saline. Acad Emerg Med. 2007;14:105-11. [PMID: 17267527] CrossrefMedlineGoogle Scholar7. Weinberg GL. Lipid infusion therapy: translation to clinical practice [Editorial]. Anesth Analg. 2008;106:1340-2. [PMID: 18420841] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Illinois at Chicago College of Medicine, Chicago, IL 60612, and Riddle Memorial Hospital, Media, PA 19063.Disclosures:Patents received: Dr. Weinberg was awarded US Patent 7,261,903 B1, related to lipid therapy. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntravenous Lipid Emulsion as Salvage Treatment for Haloperidol ToxicityLipid emulsion for acute organophosphate insecticide poisoning – a pilot observational safety studyLipid emulsion mitigates impaired pulmonary function induced by limb ischemia/reperfusion in rats through attenuation of local cellular injury and the subsequent systemic inflammatoryThe use of intravenous lipid emulsion therapy in acute methamphetamine toxicityUse of Intravenous Fat Emulsion in the Emergency Department for the Critically Ill Poisoned PatientEvaluation of intravenous lipid emulsion on haloperidol-induced hypotension in rabbitsSystematic review of the effect of intravenous lipid emulsion therapy for non-local anesthetics toxicityThe possible role of intravenous lipid emulsion in the treatment of chemical warfare agent poisoningA randomized, controlled clinical trial of intravenous lipid emulsion as an adjunctive treatment for permethrin toxicosis in catsLipid Emulsion in Treatment of Local Anesthetic ToxicityInvolvement of Opioid Receptors in the Lipid Rescue of Bupivacaine-Induced CardiotoxicityThe effects of intravenous lipid emulsion on prolongation of survival in a rat model of calcium channel blocker toxicityIntravenous Lipid Emulsion as Antidote: Experience in Hong KongHaloperidol imprinted polymer: preparation, evaluation, and application for drug assay in brain tissueShould we consider the infusion of lipid emulsion in the resuscitation of poisoned patients?Intravenous Lipids: Antidotal Therapy for Drug Overdose and Toxic Effects of Local AnestheticsPretreatment With Intravenous Lipid Emulsion Reduces Mortality From Cocaine Toxicity in a Rat ModelReview of the Use of Lipid Emulsion in Nonlocal Anesthetic PoisoningLipid rescue: does the sink hold water? And other controversiesResuscitation with Lipid EmulsionIntravenous Lipid Emulsion for the Treatment of Drug ToxicityIntravenous Lipid Emulsion Alters the Hemodynamic Response to Epinephrine in a Rat ModelRapid Cardiotonic Effects of Lipid Emulsion Infusion*Inotropic Effect of Lipid EmulsionIvermectin-induced blindness treated with intravenous lipid therapy in a dogThe Use of IV Lipid Emulsion for Lipophilic Drug ToxicitiesUse of intravenous lipid emulsion to treat ivermectin toxicosis in a Border ColliePartition constant and volume of distribution as predictors of clinical efficacy of lipid rescue for toxicological emergenciesThe use of intravenous lipid emulsion as an antidote in veterinary toxicologyReview article: Intravenous lipid emulsion as antidote: A summary of published human experienceLes émulsions lipidiques dans le traitement des effets cardiotoxiques des médicaments lipophiles autres que les anesthésiques locaux: antidote ou traitement d'exception?The role of lipid emulsion during advanced cardiac life support for local anesthetic toxicityLocal Anesthetic ToxicityComplications of peripheral nerve blocksSafety of High Volume Lipid Emulsion InfusionGift of the glob goes globalLipid rescue: the use of lipid emulsions to treat local anaesthetic toxicityLipid resuscitation for local anesthetic toxicity: is it really lifesaving?A commentary on the effect of lipid emulsions on pathology testsIntravenous Lipid Emulsion as Antidote Beyond Local Anesthetic Toxicity: A Systematic Review 19 May 2009Volume 150, Issue 10Page: 737-738KeywordsDrug administrationDrugsElectrocardiographyHeartHeart rateLipidsResuscitationTachycardiaToxicity ePublished: 19 May 2009 Issue Published: 19 May 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. 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