Inhibition of Pyrazinamide Hyperuricemia by Small Doses of Acetylsalicylic Acid
Authors: THOMAS L. PETTY
Journal: Annals of Internal Medicine (1964)

Brief Communications1 May 1964Inhibition of Pyrazinamide Hyperuricemia by Small Doses of Acetylsalicylic AcidTHOMAS L. PETTY, M.D., GLENN V. DALRYMPLE, M.D.THOMAS L. PETTY, M.D.Search for more papers by this author, GLENN V. DALRYMPLE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-5-898 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHyperuricemia is a common finding in patients treated with the antituberculous drug pyrazinamide (PZA) (1). Hyperuricemia results from decreased renal excretion of urate (2, 3). This can be due to increased tubular urate reaborption (2, 3), decreased tubular urate secretion (4), or, theoretically, by a combination of both mechanisms. PZA-induced hyperuricemia causes a small but significant incidence of attacks of acute gouty arthritis (5). In addition, moderate arthralgias occasionally occur in patients receiving a prolonged course of PZA (6).Probenecid (Benemid®) is only transiently effective in reducing PZA hyperuricemia (1, 5). Other reports suggest that both para-amino-salicylic acid (PAS) and...References1. SHAPIROHYDE ML: Hyperuricemia due to pyrazinamide. Amer. J. Med. 23: 596, 1957. CrossrefMedlineGoogle Scholar2. GLEASONSTREETKAHN DFJPKA: Effects of pyrazinamide on serum and urine uric acid. Transactions, VA-Armed Forces Conference on Chemotherapy of Tuberculosis 16: 239, 1957. Google Scholar3. CULLENLEVINEFIORE JHMJM: Studies of hyperuricemia produced by pyrazinamide. Amer. J. Med. 23: 587, 1957. CrossrefMedlineGoogle Scholar4. GUTMANYUBERGER ABTFL: Tubular secretion of urate in man. J. Clin. Invest. 38: 1778, 1959. CrossrefMedlineGoogle Scholar5. KANNERJACOBS OP: Elevation of blood serum uric acid levels with chemotherapy. Transactions, VA-Armed Forces Conference on Chemotherapy of Tuberculosis 16: 244, 1957. Google Scholar6. PETTY TL: Unpublished observations. Google Scholar7. WOOD PH: Salicylates. Bull. Rheum. Dis. 13: 297, 1963. MedlineGoogle Scholar8. PETTYMITCHELL TLRS: Successful treatment of advanced isoniazid- and streptomycin-resistant pulmonary tuberculosis with ethionamide, pyrazinamide, and isoniazid. Amer. Rev. Resp. Dis. 86: 503, 1962. MedlineGoogle Scholar9. FORSHAMTHORNPRUNTYHILLS PHGWFTAG: Clinical studies with pituitary adrenocorticotropin. J. Clin. Endocr. 8: 15, 1948. CrossrefMedlineGoogle Scholar10. YUGUTMAN TFAB: Study of the paradoxical effects of salicylate in low, intermediate, and high dosage on the renal mechanisms for excretion of urate in man. J. Clin. Invest. 38: 1298, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: THOMAS L. PETTY, M.D.; GLENN V. DALRYMPLE, M.D.Affiliations: Denver, ColoradoFrom the Departments of Medicine and Radiology, University of Colorado School of Medicine, and the Webb-Waring Institute for Medical Research, both of Denver, Colorado.Requests for reprints should be addressed to Thomas L. Petty, M.D., Webb-Waring Institute for Medical Research, 4200 East 9th Avenue, Denver 20, Colorado. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRepurposing Immunomodulatory Drugs to Combat TuberculosisThe Manipulation of the Lipid Mediator Metabolism as Adjunct Host-Directed Therapy in TuberculosisThe Immune Mechanisms of Lung Parenchymal Damage in Tuberculosis and the Role of Host-Directed TherapyNon-Steroidal Anti-inflammatory Drugs As Host-Directed Therapy for Tuberculosis: A Systematic ReviewParadoxical increase in uric acid level with allopurinol use in pyrazinamide-induced hyperuricaemiaClinical Aspects of Gout and Associated Disease StatesHyperuricemia and Arthralgias During Pyrazinamide Therapy in Patients With Pulmonary TuberculosisDrug-induced goutHyperuricaemia induced by ethambutolSALICYLIC ACIDHyperuricemia Induced by EthambutolStudies on the mechanism of ethambutol-induced hyperuricemia 1 May 1964Volume 60, Issue 5Page: 898-900KeywordsArthralgiaArthritisDiagnostic radiologyDrugsExcretionPeriodic acid SchiffTuberculosisUric acid ePublished: 1 December 2008 Issue Published: 1 May 1964 PDF downloadLoading ...