Scientific Methodology in Clinical Medicine
Authors: ALVAN R. FEINSTEIN
Journal: Annals of Internal Medicine (1964)

Special Article1 September 1964Scientific Methodology in Clinical MedicineI. Introduction, Principles, and ConceptsALVAN R. FEINSTEIN, M.D.ALVAN R. FEINSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-3-564 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe following paper is the first of four parts of Dr. Feinstein's cogent analysis of scientific methodology in clinical medicine. The subsequent parts will appear in consecutive issues of theANNALS,October through December, and are subtitled as follows: "II. Classification of Human Disease by Clinical Behavior," "III. The Evaluation of Therapeutic Response," and "IV. Acquisition of Clinical Data." These special articles should go far to demonstrate that the scientific heritage of Francis Bacon is just as relevant to the bedside of the patient as it is to the research laboratory. The practice of clinical medicine is surely an art,...Reference1. FEINSTEIN AR: Boolean algebra and clinical taxonomy. I. Analytic synthesis of the general spectrum of a human disease. New Eng. J. Med. 269: 929-938, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Haven, ConnecticutFrom the Department of Medicine (Clinical Biostatistics Section), Veterans Administration Hospital, West Haven, Conn., and the Department of Medicine, Yale University School of Medicine, New Haven, Conn.The work described here was conceived and prepared during investigations supported by grants HE01595 from the National Heart Institute and CA07155 from the National Cancer Institute, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Alvan R. Feinstein, M.D., Associate Professor of Medicine, Yale University School of Medicine, 333 Cedar St., New Haven, Conn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEvidence‐based medicine's curious path: From clinical epidemiology to patient‐centered care through decision analysisThe Development of Cancer Screening GuidelinesNovel aspects in diagnostic approach to respiratory patients: is it the time for a new semiotics?Oral Examination and ChartingWhat We Talk about When We Talk about Risk: Refining Surgery's Hazards in Medical ThoughtLogic Structure of Clinical Judgment and Its Relation to Medical and Psychiatric SemiologyPhilosophy and Concepts of Modern Spine SurgeryViewpoint: Envisioning the Successful Integration of EBM and Humanism in the Clinical Encounter: Fantasy or Fallacy?Central dimensions of clinical practice evaluation: efficiency, appropriateness and effectiveness - IIRelative Prognostic Importance of Histologic Invasion of the Laryngeal Framework by Hypopharyngeal CancerScientific Methodology in Temporomandibular Disorders. Part II: EthologyThe Teaching of Statistics in the Biological, Medical and Health Sciences: Some Comments and a Selected BibliographyPressure sore prevention and treatment: an example of nurses' failure to implement research findingsHistory-Taking and Development of the Examination RecordRound Table DiscussionINTRODUCTION TO EPIDEMIOLOGYA Short History of Evidence-Based MedicineEffect of Secretin in Celiac and Superior Mesenteric AngiographyCompassion, Computers, and the Regulation of Clinical TechnologyALVAN R. FEINSTEIN, M.D., F.A.C.P.Clinical and Intellectual Causes of Defective Statistics for the Prognosis and Treatment of Lung CancerThe Changing Emphasis in Clinical Research I. Topics Under Investigation. An Analysis of the Submitted Abstracts and Selected Programs at the Annual "Atlantic City Meetings" During 1953 Through 1965ALVAN R. FEINSTEIN, M.D., F.A.C.P., NEAL KOSS, M.D., JOHN H. M. AUSTIN, M.D.On statistical testing of prevalence studies“Time Present and Time Past are Both Perhaps Present in Time Future”Scientific Methodology in Clinical Medicine IV. Acquisition of Clinical DataALVAN R. FEINSTEIN, M.D., F.A.C.P.Scientific Methodology in Clinical Medicine III. The Evaluation of Therapeutic ResponseALVAN R. FEINSTEIN, M.D.Scientific Methodology in Clinical Medicine II. Classification of Human Disease by Clinical BehaviorALVAN R. FEINSTEIN, M.D. 1 September 1964Volume 61, Issue 3Page: 564-579KeywordsBehaviorBiostatisticsData acquisitionHeartHospital medicineMedical servicesResearch laboratories Issue Published: 1 September 1964 PDF downloadLoading ...