The Systemic Capillary Leak Syndrome
Authors: Mark Pecker, Michael Adams, Walter Graham
Journal: Annals of Internal Medicine (2011)

Letters6 September 2011The Systemic Capillary Leak SyndromeMark Pecker, MD, Michael Adams, MD, and Walter Graham, MDMark Pecker, MDFrom Weill Cornell Medical College, New York, NY 10021; Georgetown University School of Medicine, Washington, DC 20057; and Cassia Regional Medical Center, Burley, ID 83318.Search for more papers by this author, Michael Adams, MDFrom Weill Cornell Medical College, New York, NY 10021; Georgetown University School of Medicine, Washington, DC 20057; and Cassia Regional Medical Center, Burley, ID 83318.Search for more papers by this author, and Walter Graham, MDFrom Weill Cornell Medical College, New York, NY 10021; Georgetown University School of Medicine, Washington, DC 20057; and Cassia Regional Medical Center, Burley, ID 83318.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-5-201109060-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read the article by Gousseff and colleagues (1) on the systemic capillary leak syndrome (SCLS) with great interest. However, we differ with their conclusion implying that β2-agonists and intravenous immunoglobulin (IVIG) provide equivalent prophylaxis.The data presented by Gousseff and colleagues show that none of the 8 patients who died in the study were receiving prophylactic treatment at the time of death. Eleven of the 20 remaining patients were initially treated with β2-agonists, but almost all of the survivors were migrated to prophylaxis with IVIG over time. Eight of the 18 patients receiving IVIG had no ...References1. Gousseff M, Arnaud L, Lambert M, Hot A, Hamidou M, Duhaut P, et al; Capillary Leak Syndrome Registry. The systemic capillary leak syndrome: a case series of 28 patients from a European registry. Ann Intern Med. 2011;154:464-71. [PMID: 21464348] LinkGoogle Scholar2. Lambert M, Launay D, Hachulla E, Morell-Dubois S, Soland V, Queyrel V, et al. High-dose intravenous immunoglobulins dramatically reverse systemic capillary leak syndrome. Crit Care Med. 2008;36:2184-7. [PMID: 18552679] CrossrefMedlineGoogle Scholar3. Abguueguen P, Chennebault JM, Pichard E. Immunoglobulins for treatment of systemic capillary leak syndrome. Am J Med. 2010;123:3-4. [PMID: 20569743] CrossrefMedlineGoogle Scholar4. Govig BA, Javaheri S. The systemic capillary leak syndrome [Letter]. Ann Intern Med. 2010;153:764. [PMID: 21135305] LinkGoogle Scholar5. Zipponi M, Eugster R, Birrenbach T. High-dose intravenous immunoglobulins: a promising therapeutic approach for idiopathicsystemic capillary leak syndrome. BMJ Case Reports. 2011;:. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Weill Cornell Medical College, New York, NY 10021; Georgetown University School of Medicine, Washington, DC 20057; and Cassia Regional Medical Center, Burley, ID 83318.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Systemic Capillary Leak Syndrome Bert A. Govig and Sepehr Javaheri The Systemic Capillary Leak Syndrome: A Case Series of 28 Patients From a European Registry Marie Gousseff , Laurent Arnaud , Marc Lambert , Arnaud Hot , Mohamed Hamidou , Pierre Duhaut , Thomas Papo , Martin Soubrier , Marc Ruivard , Giuseppe Malizia , Nathalie Tieulié , Sophie Rivière , Jacques Ninet , Pierre-Yves Hatron , Zahir Amoura , and The Systemic Capillary Leak Syndrome Laurent Arnaud , Marie Gouseff , and Zahir Amoura Metrics Cited ByCapillary leak syndrome: etiologies, pathophysiology, and managementIdiopatic Systemic Capillary Leak Syndrome Treated Successfully with High-Dose Intravenous ImmunoglobulinsHigh-dose Intravenous Immunoglobulin Therapy for Systemic Capillary Leak Syndrome (Clarkson Disease)Multiglandular Hormone Deficiency in a Patient with Systemic Capillary Leak SyndromeSystemic capillary leak syndrome: recognition prevents morbidity and mortalityGenome-wide SNP analysis of the Systemic Capillary Leak Syndrome (Clarkson disease) 6 September 2011Volume 155, Issue 5Page: 335KeywordsCapillariesHematocritHemoglobinHospitalizationsHypotensionMedical dialysisProphylaxisRenal failure ePublished: 6 September 2011 Issue Published: 6 September 2011 CopyrightCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...