tbuckley/cabot-search huggingface dataset:
The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair
Authors: Guangpei Hou, Wolfgang Vogel, Michelle P. Bendeck
Journal: Journal of Clinical Investigation (2001)

Collagens act as important signaling molecules regulating vascular smooth muscle cell responses during arterial wound repair. Discoidin domain receptors (DDRs) are a novel class of receptor tyrosine kinases that bind to several collagens and stimulate matrix metalloproteinase (MMP) production, but little is known about their expression and function in the vasculature. We posited a critical role for the DDRs controlling smooth muscle cell migration and proliferation and thus repair following arterial injury. Smooth muscle cells were isolated from the aortas of mice with a targeted deletion of the DDR1 gene (DDR1-null) and studied in culture using models that mimic critical steps in neointimal thickening. Our studies suggest that DDR1 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. Following mechanical injury to the carotid arteries, cross-sectional area of the neointima was significantly lower in DDR1-null mice than in wild-type mice. There was also a significant decrease in collagen deposition in the injured arteries of the DDR1-null mice. Our results support the hypothesis that DDR1 plays an important role as a collagen receptor, mediating intimal thickening after vascular injury.
Medical journals in the market place
Authors: M. O'Donnell
Journal: BMJ (1982)

January 1982 we saw an 18-year-old woman who developed erythema nodosum two weeks after the onset of bacteriologically proved campylobacter enteritis.For the previous three to four years she had had discomfort in her left knee without swelling.Since the onset of erythema nodosum her left knee had been more painful, and on examination it was slightly swollen and tender.No other articular or extra-articular abnormalities were detected clinically.Investigation showed the following: haemoglobin concentration 13 g/dl, total white-cell count 4-7 x 109/1, platelet count 219 x 109/1, erythrocyte sedimentation rate in the first hour 20 mm, Campylobacter jejuni complement fixation test titre 1:10, antibodies to Salmonella typhi, paratyphi H and 0 antigens, and Yersinia not detected, Rose- Waaler test negative, antistreptolysin-O titre 240 IU, antinuclear factor titre negative, chest radiograph normal, HLA Al, 29; B8, 12. Her symptoms resolved over two weeks and the signs of erythema nodosum over six weeks.She has remained well since.On the basis of the cases reported to date Campylobacter jejuni would appear to be an established cause of erythema nodosum and may be associated with synovitis in these circumstances.
The Mitochondrial Genome of Phoronis architecta—Comparisons Demonstrate that Phoronids Are Lophotrochozoan Protostomes
Authors: Kevin G. Helfenbein, Jeffrey L. Boore
Journal: Molecular Biology and Evolution (2004)

The proper reconstruction of the relationships among the animal phyla is central to interpreting patterns of animal evolution from the genomic level to the morphological level. This is true not only of the more speciose phyla but also of smaller groups. We report here the nearly complete DNA sequence of the mitochondrial genome of the phoronid Phoronis architecta, which has a gene arrangement remarkably similar to that of a protostome animal, the chiton Katharina tunicata. Evolutionary analysis of both gene arrangements and inferred amino acid sequences of these taxa, along with those of three brachiopods and other diverse animals, strongly supports the hypothesis that lophophorates are part of the large group that includes mollusks and annelids-i.e., the Lophotrochozoa-and solidly refutes the alternative of their being deuterostomes.
The Genome Gets Personal—Almost
Authors: W Gregory Feero, Alan E Guttmacher, Francis S Collins
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
F-18 FDG PET-CT Imaging in Recurrent Cerebral Gliosarcoma
Authors: Linh Thuy Ho, Heidi Wassef, Robert Henderson, John Seto
Journal: Clinical Nuclear Medicine (2009)

We report the F-18 FDG PET-CT appearance of recurrent gliosarcoma (GS) with extracranial extension in a 47-year-old man who underwent surgical resection of a right frontal GS 5 months earlier. F-18 FDG PET demonstrated moderate uptake in the recurrent disease. GS is a very rare, biphasic primary neoplasm of the central nervous system, composed of glioblastoma multiforme mixed with a sarcomatous component. It occurs in adults of middle age and carries a poor prognosis. The median survival reported is less than a year. The results suggest that F-18 FDG PET imaging may be useful in detecting recurrent GS.
Hypothyroidism and Stress
Authors: Elliott Eisenbud
Journal: JAMA (1975)

To the Editor.—  The recent report by Mataverde et al (230:1014, 1974) is timely in pointing out a commonly encountered but not well recognized problem. A less common problem, but one that may have been a factor in the case presented, is the exacerbation of hypothyroidism during periods of stress.  An early report 1 describes five patients who developed  myxedema following pneumonia. Subsequent work 2 has shown that during stress thyroxine (T 4 ) turnover is increased fivefold while plasma T 4 levels were maintained within normal limits, thus suggesting an increase in T 4 secretory rate. It was thought that the increased turnover was the result of an increase in free T 4 caused by a decrease in thyroxine-binding prealbumin (TBPA). More recent work 3 has confirmed that TBPA does indeed decrease with acute infections, but this was dissociated in time from changes in free T 4 . It was concluded
Endoscopic Ultrasound Added to Mediastinoscopy for Preoperative Staging of Patients With Lung Cancer
Authors: Jouke T. Annema
Journal: JAMA (2005)

Up to 40% of thoracotomies performed for non-small cell lung cancer are unnecessary, predominantly due to inaccurate preoperative detection of lymph node metastases and mediastinal tumor invasion (T4). Mediastinoscopy and the novel, minimally invasive technique of transesophageal ultrasound-guided fine-needle aspiration (EUS-FNA) target different mediastinal lymph node stations. In addition, EUS can identify tumor invasion in neighboring organs if tumors are located adjacent to the esophagus.To investigate the additional value of EUS-FNA to mediastinoscopy in the preoperative staging of patients with non-small cell lung cancer.Prospective, nonrandomized multicenter trial performed in 1 referral and 5 general hospitals in the Netherlands. During a 3-year period (2000-2003), 107 consecutive patients with potential resectable non-small cell lung cancer underwent preoperative staging by both EUS-FNA and mediastinoscopy. Patients underwent thoracotomy with tumor resection if mediastinoscopy was negative. Surgical-pathological staging was compared with preoperative findings and the added benefit of the combined strategy was assessed.The EUS-FNA examination was performed as an additional staging test to mediastinoscopy in all patients.Detection of mediastinal tumor invasion (T4) and lymph node metastases (N2/N3) comparing the combined staging by both EUS-FNA and mediastinoscopy with staging by mediastinoscopy alone.The combination of EUS-FNA and mediastinoscopy identified more patients with tumor invasion or lymph node metastases (36%; 95% confidence interval [CI], 27%-46%) compared with either mediastinoscopy alone (20%; 95% CI, 13%-29%) or EUS-FNA (28%; 95% CI, 19%-38%) alone. This indicated that 16% of thoracotomies could have been avoided by using EUS-FNA in addition to mediastinoscopy. However, 2% of the EUS-FNA findings were false-positive.These preliminary findings suggest that EUS-FNA, when added to mediastinoscopy, improves the preoperative staging of lung cancer due to the complementary reach of EUS-FNA in detecting mediastinal lymph node metastases and the ability to assess mediastinal tumor invasion.
ARE CORONARY ARTERY CALCIUM SCORE AND/OR CT ANGIOGRAPHY APPROPRIATE FOR ASYMPTOMATIC PATIENTS WITH HIGH PRETEST PROBABILITY?
Authors: Takeshi Kondo, Shinichiro Fujimoto, Kazuhisa Takamura, Hiroshi Arai, Tadaaki Orihara, Junichi Sugiyama, Makoto Kondo, Akira Endo, Hiroshi Fukazawa, Hideki Nagaoka, Akitsugu Oida, Shinichi Takase, Jagat Narula
Journal: Journal of the American College of Cardiology (2013)
HYPEREMIC FFR AND BASELINE IFR HAVE AN EQUIVALENT DIAGNOSTIC ACCURACY WHEN COMPARED TO MYOCARDIAL BLOOD FLOW QUANTIFIED BY H215O PET PERFUSION IMAGING
Authors: Guus de Waard, Ibrahim Danad, Ricardo Petraco da Cunha, Paul Teunissen, Tim van de Hoef, Pieter Raijmakers, Adriaan Lammertsma, Justin Davies, Paul Knaapen, Niels Van Royen
Journal: Journal of the American College of Cardiology (2014)
Abstract C46: The pharmacokinetics and pharmacodynamics study of honokiol in Sprague-Dawley rats and colorectal tumor-bearing mice
Authors: Yung-Jen Tsai, Pei-Yi Tsai, Le-Mei Hung, Mei-Yin Su, Min-Hui Lin, Lung-Yu Kuan, Yih-Chiao Tsai, Hui-Ling Chen, Jia-Ming Chang
Journal: Cancer Research (2013)

Abstract Honokiol, a small-molecule pharmacological bioactive constituent of the bark of Magnolia plants, has shown anti-tumor effect in a variety of human cancer xenograft models through the induction of apoptosis. Additionally, honokiol could enhance the cytotoxicity in combination of oxaliplatin in colon cancer cells. To investigate the anti-tumor effect and the pharmacokinetics (PK) of honokiol, honokiol was tested for anti-tumor activity in a colorectal cancer xenograft mice model and oral-bioavailability of honokiol was assayed in Sprague-Dawley rats. The pharmacokinetic results of 5.0 mg/kg honokiol after intravenous injection showed that the elimination half time was about 0.79 ± 0.03 hours, the Cmax was about 752.67 ± 58.36 ng/mL, and the mean residence time (MRT) was about 0.85 ± 0.05 hours. In vivo study for testing anti-cancer activity of honokiol is underwent and expected that honokiol would inhibit the tumor growth in colorectal tumor-bearing mice. In conclusion, honokiol may be developed be as therapeutic agent for cancer treatment in combination with PK and pharmacodynamics (PD) data. Citation Format: Yung-Jen Tsai, Pei-Yi Tsai, Le-Mei Hung, Mei-Yin Su, Min-Hui Lin, Lung-Yu Kuan, Yih-Chiao Tsai, Hui-Ling Chen, Jia-Ming Chang. The pharmacokinetics and pharmacodynamics study of honokiol in Sprague-Dawley rats and colorectal tumor-bearing mice. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr C46.
Propranolol in black hypertensives.
Authors: G A Grell
Journal: BMJ (1978)

when approximately 84 million patients had received the parenteral form.Typically, those who abuse pentazocine also abuse narcotics and other drugs.'Pentazocine alone does not produce a typical opiate abstinence syndrome,2 and withdrawal symptoms are not usually severe and do not require treatment.3In the group reported by Drs King and Betts the symptoms are described as severe; lasting more than two weeks, and resembling those of diamorphine withdrawal.Clearly this runs contrary to the general experience of pentazocine dependence.Subjective testimony alone cannot be regarded as sufficient evidence to establish which drug is being abused,4 since it is reported that analysis revealed no trace of pentazocine in six subjects alleging dependence on this drug, while in five there was evidence of morphine or pethidine usage.5Finally, the authors give no indication of the relative frequency of alleged pentazocine abuse.Comparative data are needed to put their experience into correct perspective.If these data could be made available, then the report can be properly evaluated.
Abstract 5343: Identification of brain tumor initiating cells using the stem cell marker aldehyde dehydrogenase 1
Authors: Seung Ah Choi, Ji Yeoun Lee, Ji Hoon Phi, Kyu-Chang Wang, Chul-Kee Park, Sung-Hye Park, Seung-Ki Kim
Journal: Cancer Research (2012)

Abstract Aldehyde dehydrogenase 1 (ALDH1) has been identified in stem cells from both normal and cancerous tissue. This study aimed to evaluate the potential of ALDH1 as a universal brain tumor initiating cell (BTIC) marker applicable to primary brain tumors and their biological role in maintaining stem cell status. Cells from various primary brain tumors (24 pediatric and 6 adult brain tumors) were stained with Aldefluor and sorted by flow cytometry. We investigated the impact of ALDH1 expression on BTIC characteristics in vitro and on tumorigenic potential in vivo. Primary cultured brain tumor cells showed universal expression of ALDH1, with 0.3 to 28.9% of the cells in various tumors identified as ALDH1+. ALDH1+ cells generate neurospheres with high proliferative potential, express neural stem cell markers (nestin and musashi) and differentiate into multiple nervous system lineages. ALDH1+ cells are phenotypically distinct from CD133+ cells, and they show high expression of induced pluripotent stem cell-related genes. Notably, targeted knockdown of ALDH1 by shRNA interference in BTICs potently disturbed their self-renewing ability. After three months, ALDH1+ cells gave rise to tumors in 93% of mice whereas ALDH1- cells did not. The characteristic pathology of mice brain tumors from ALDH1+ cells was similar to that of human brain tumors, and these cells are highly proliferative in vivo. Our data suggest that primary brain tumors contain distinct subpopulations of cells that have high expression levels of ALDH1 and BTIC characteristics. ALDH1 might be a potential therapeutic target applicable to primary brain tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5343. doi:1538-7445.AM2012-5343
Peaks and troughs in demands on hospitals
Authors: M F H Bush
Journal: BMJ (1988)

Peaks and troughs in demands on hospitals M F H Bush, FFCM     786 Should the pill be stopped preoperatively? J Guillebaud, FRCOG; Gillian Robinson, MB, and others; G C Kassianos, MD, and others .... 786 Personal computers in the Third World Krisantha Weerasuriya, MRCP   787 Carbon monoxide poisoning R J M W Howard, MB; T Meredith, MRCP, and A Vale, FRCP; J R Broome, MRCP, and R R Pearson, MD; S C Cheetham, MSC, and others   787 Newly registered elderly patients J K Bynoe, MRCGP     788 Psychiatry: private and public provision T H Turner, MRCPSYCH, and D Widgery, MB 789 Viral infection, human papillomavirus DNA, and cervical neoplasia W P Soutter, MRCOG     789 Variability in biothesiometry: an error of technique? J M S Pearce, FRCP; G Williams, MRCP, and others   789 Anaesthetic services in obstetrics M Rosen, FFARCS   790 Chronic fetal hypoxia in diabetic pregnancy Fiona M Fairlie, MRCOG, and others; R J Bradley, MRCOG, and others; F D Johnstone, FRCOG,and others   790 Clinical experimentation in obstetrics D F Hawkins, FRCOG   791 Merit awards RH R White, FRCP     791 The Shaw report E MacDonald, FRCOG   791 Points: Aspirin megatrials (J P Vandenbroucke); Dietary management of gastroenteritis in Britain (R J Wilson); Should colonoscopy be the first investigation for colonic disease? (J Rawlinson and others); Advice on contraceptive services for ethnic minorities (B R McAvoy and Rabia Raza); Special footwear (R G S Platts); Financial deprivation in the NHS (P F Roberts); Secretor state of patients with diabetes mellitus (P-J Lamey and others); Clumsy children (K Pearman and others); Upper gastrointestinal Kaposi's sarcoma in patients positive for HIV antibody (C P Conlon); Use of the word abortion (R A A R Lawrence) 792
A piece of my mind. A memory of blood
Authors: J. D. Gewirtz
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Differentiation of Human Prostate Cancer PC-3 Cells Induced by Inhibitors of Inosine 5′-Monophosphate Dehydrogenase
Authors: Daniel Floryk, Sandra L. Tollaksen, Carol S. Giometti, Eliezer Huberman
Journal: Cancer Research (2004)

Abstract To establish a system to study differentiation therapy drugs, we used the androgen-independent human prostate PC-3 tumor cell line as a target and mycophenolic acid (MPA), tiazofurin, or ribavirin, which are inhibitors of IMP dehydrogenase, as inducers. These inhibitors evoked replication arrest, caused an increase in cell size, and triggered vacuolization of the cytoplasm. By Northern and Western blotting and immunostaining, we demonstrated MPA-induced expression of 12 proteins reported to reside in prostasomes, organelles released by secretory luminal prostate cells. Additional MPA-induced proteins were identified by two-dimensional gel electrophoresis. Among these was keratin 17, a prostate cell differentiation marker. By Northern blotting, we also demonstrated the constitutive expression of keratins 8 and 18 and induced expression of keratin 19, three other prostate cell differentiation markers. In addition, we established that cells were committed to differentiate after the 2nd day of MPA treatment using guanosine, which can abrogate the effects of MPA. Based on the expression patterns of prostasomal proteins and keratins and the presence of tentative secretory vacuoles, we hypothesize that IMP dehydrogenase inhibitors induce androgen-independent PC-3 cells to mature into cells with a phenotype that resembles normal prostate luminal cells, but at their intermediate state of differentiation.
Posttraumatic Stress Without Trauma in Children
Authors: William E. Copeland, Gordon Keeler, Adrian Angold, E. Jane Costello
Journal: American Journal of Psychiatry (2010)

Objective: It remains unclear to what degree children show signs of posttraumatic stress disorder (PTSD) after experiencing low-magnitude stressors, or stressors milder than those required for the DSM-IV extreme stressor criterion. Method: A representative community sample of 1,420 children, ages 9, 11, and 13 at intake, was followed annually through age 16. Low-magnitude and extreme stressors as well as subsequent posttraumatic stress symptoms were assessed with the Child and Adolescent Psychiatric Assessment. Two measures of posttraumatic stress symptoms were used: having painful recall, hyperarousal, and avoidance symptoms (subclinical PTSD) and having painful recall only. Results: During any 3-month period, low-magnitude stressors occurred four times as often as extreme stressors (24.0% compared with 5.9%). Extreme stressors elicited painful recall in 8.7% of participants and subclinical PTSD in 3.1%, compared with 4.2% and 0.7%, respectively, for low-magnitude stressors. Because of their higher prevalence, however, low-magnitude stressors accounted for two-thirds of cases of painful recall and half of cases of subclinical PTSD. Moreover, exposure to low-magnitude stressors predicted symptoms even among youths with no prior lifetime exposure to an extreme stressor. Conclusions: Relative to low-magnitude stressors, extreme stressors place children at greater risk for posttraumatic stress symptoms. Nevertheless, a sizable proportion of children manifesting posttraumatic stress symptoms experienced only a low-magnitude stressor.
Intravenous Verapamil for Termination of Re-Entrant Supraventricular Tachycardias
Authors: RUEY J. SUNG
Journal: Annals of Internal Medicine (1980)

We evaluated efficacy and mechanisms of the antiarrhythmic action of verapamil in 20 patients with sustained supraventricular tachycardia. Two patients had sinus nodal re-entrant tachycardia, nine atrioventricular (AV) nodal re-entrant tachycardia, and nine AV reciprocating tachycardia associated with the Wolff-Parkinson-White syndrome. The study design comprised a double-blind, randomized, cross-over phase using a 0.075 mg/kg dose of verapamil versus placebo and an open-label phase using a 0.15 mg/kg dose of verapamil. The overall results of both phases showed that 15 of 19 patients converted to sinus rhythm with verapamil while only one of 16 converted to sinus rhythm with placebo. The effective plasma verapamil concentration measured 123 +/- 40 ng/mL (mean +/- SD). Verapamil suppressed sinus nodal and AV nodal re-entry but exerted no selective depression between fast and slow AV nodal pathways. It had no significant effect on accessory AV bypass tract but was effective in terminating AV reciprocating tachycardia by its depressive action on the AV node.
Pox: An American History
Authors: René Vollenbroich
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal