tbuckley/cabot-search huggingface dataset:
Neutral Endopeptidase Is Activated in Cardiomyocytes in Human Aortic Valve Stenosis and Heart Failure
Authors: Jens Fielitz, Andreas Dendorfer, Reinhard Pregla, Elisabeth Ehler, Heinz R. Zurbrügg, Jozef Bartunek, Roland Hetzer, Vera Regitz-Zagrosek
Journal: Circulation (2002)

Background — The regulation of the cardiac neutral endopeptidase (EC 24.10, NEP) that degrades bradykinin and natriuretic peptides has been investigated in human cardiac hypertrophy and heart failure. Methods and Results — NEP mRNA was quantitated by real-time polymerase chain reaction (PCR) in left ventricular biopsies from patients with aortic valve stenosis (AS, n=19) and heart failure due to dilated cardiomyopathy (DCM, n=14), and control subjects with normal systolic function (CON, n=14). Left ventricular NEP mRNA content was increased 3-fold in AS ( P &lt;0.005) and 4.1-fold in DCM ( P &lt;0.002). The increase in NEP mRNA was related to the increase in end diastolic pressure in AS and DCM. In a second series, myocardial NEP enzymatic activity was determined. It increased 3.6-fold in AS ( P &lt;0.02) and 4-fold in DCM ( P &lt;0.002). NEP was localized in the myocardium by immunofluorescence microscopy and in situ PCR to myocytes and nonmyocyte areas and cells. Conclusions — Elevated cardiac NEP activity in pressure loaded and failing human hearts may increase the local degradation of bradykinin and natriuretic peptides.
Dementia and Activities of Daily Living
Authors: Fernando Coto-Yglesias
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Skin Carcinoma of the Face and Neck
Authors: P. Haines Ely
Journal: JAMA (1982)

<h3>To the Editor.—</h3> Donald G. Lindsay, MD (1981;246:733), wrote that "radiation therapy of skin cancer is not carefully chosen nor well planned no matter how meticulously administered unless it is done with a consideration for the posttreatment result 20 to 25 years hence." The reply to Dr Lindsay's letter by Chahin M. Chahbazian, MD, and G. Stephen Brown, MD, did not address this point. Do Drs Chahbazian and Brown have any 25-year follow-ups on their proposed radiation therapy? The key point that Dr Lindsay made is that 20 to 25 years after radiation therapy, there is a breakdown of radiated skin. Where is Drs Chahbazian and Brown's evidence to refute this? Certainly not in their response to Dr Lindsay.
FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells
Authors: Martine van Keimpema, Leonie J. Grüneberg, Michal Mokry, Ruben van Boxtel, Jan Koster, Paul J. Coffer, Steven T. Pals, Marcel Spaargaren
Journal: Blood (2014)
THE RELATIONSHIP OF SCHOOL PHOBIA TO CHILDHOOD DEPRESSION
Authors: STEWART AGRAS
Journal: American Journal of Psychiatry (1959)

The thesis put forward in this paper is that school phobia is part of the natural history of the depressive disorders, and is but one of the modes of presentation of such disorders in childhood. A family constellation, the depressive constellation, has been described as typical for these cases, and it is suspected that this type of family will be found in many of the other modes of presentation of depression in childhood. Suggestions have been made by which the propositions put forward may be checked and expanded.
Abstract LB-225: EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity
Authors: Hu Zhu, Xinyu Cao, Steve Keir, Francis Ali-Osman, Hui-Wen Lo
Journal: Cancer Research (2010)

Abstract Glioblastoma is the most common and most intractable brain malignancy in adults. Patients with glioblastoma have dismal prognosis with a median survival of 12-14 months. This unfortunate poor prognosis is, in part, due to the aggressive nature of these tumors and the lack of effective therapy. EGFR and its constitutively activated variant EGFRvIII are linked to glioblastoma resistance to therapy, the mechanisms underlying this association, however, are still unclear. We report here that in glioblastoma cell lines, xenografts and primary specimens, EGFR and EGFRvIII paradoxically co-express with p53-upregulated modulator of apoptosis (PUMA), a proapoptotic member of the Bcl-2 family of proteins primarily located on the mitochondria. Both EGFR and EGFRvIII bind to PUMA constitutively and under apoptotic stress, and subsequently sequester PUMA in the cytoplasm. The EGFR-PUMA interaction is independent of EGFR activation and is sustained under EGFR inhibition. A Bcl-2/Bcl-xL inhibitor that mimics PUMA activity sensitizes EGFR- and EGFRvIII-expressing glioblastoma cells to EGFR kinase inhibitor, Iressa. Collectively, we uncovered a novel kinase-independent function of EGFR and EGFRvIII that leads to drug resistance of glioblastoma and potentially other tumor types. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-225.
244 RIBAVIRIN-RATHER THAN PEG-INTERFERON-RELATED FACTORS ARE PREDICTING NON-RESPONSE TO ANTIVIRAL THERAPY IN NAIVE CHRONIC HEPATITIS C PATIENTS
Authors: L.G. van Vlerken, E.J. Huisman, H. van Soest, G.J. Boland, P.D. Siersema, D.M. Burger, K.J. van Erpecum
Journal: Journal of Hepatology (2010)
Proteolytic antibodies activate factor IX in patients with acquired hemophilia
Authors: Bharath Wootla, Olivier D. Christophe, Ankit Mahendra, Jordan D. Dimitrov, Yohann Repessé, Véronique Ollivier, Alain Friboulet, Annie Borel-Derlon, Hervé Levesque, Jeanne-Yvonne Borg, Sebastien Andre, Jagadeesh Bayry, Thierry Calvez, Srinivas V. Kaveri, Sébastien Lacroix-Desmazes
Journal: Blood (2010)
BepreveTM 1.5% Provides Clinically Meaningful Reduction in Allergen-Induced Ocular Itching for Subjects in an Analysis of Two Phase 3 Conjunctival Allergen Challenge (CAC) Clinical Trials
Authors: J.I. Williams, G.L. Schooley, J.A. Gow, T.R. McNamara
Journal: Journal of Allergy and Clinical Immunology (2010)
Inhibition of Ataxia Telangiectasia Mutated Kinase Activity Enhances TRAIL-Mediated Apoptosis in Human Melanoma Cells
Authors: Vladimir N. Ivanov, Hongning Zhou, Michael A. Partridge, Tom K. Hei
Journal: Cancer Research (2009)

The aim of the present study was to elucidate the effects of ataxia telangiectasia mutated (ATM) kinase on the regulation of the extrinsic tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor 2/DR5-mediated death pathway in human melanoma cells. We revealed that total ATM protein levels were high in some human melanoma lines compared with normal cells. The basal levels of active form ATM phospho-Ser(1981) were also detectable in many melanoma lines and could be further up-regulated by gamma-irradiation. Pretreatment of several melanoma lines just before gamma-irradiation with the inhibitor of ATM kinase KU-55933 suppressed p53 and nuclear factor-kappaB (NF-kappaB) activation but notably increased radiation-induced DR5 surface expression, down-regulated cFLIP (caspase-8 inhibitor) levels, and substantially enhanced exogenous TRAIL-induced apoptosis. Furthermore, gamma-irradiation in the presence of KU-55933 rendered TRAIL-resistant HHMSX melanoma cells susceptible to TRAIL-mediated apoptosis. In addition, suppression of ATM expression by the specific short hairpin RNA also resulted in down-regulation of cFLIP levels, up-regulation of surface DR5 expression, and TRAIL-mediated apoptosis in melanoma cells. Besides p53 and NF-kappaB, crucial regulators of DR5 expression, transcription factor STAT3 is known to negatively regulate DR5 expression. Suppression of Ser(727) and Tyr(705) phosphorylation of STAT3 by KU-55933 reduced STAT3 transacting activity accompanied by elevation in DR5 expression. Dominant-negative STAT3beta also efficiently up-regulated the DR5 surface expression and down-regulated cFLIP levels in melanoma cells in culture and in vivo. Taken together, our data show the existence of an ATM-dependent STAT3-mediated antiapoptotic pathway, which on suppression sensitizes human melanoma cells to TRAIL-mediated apoptosis.
Drug Taking in Adolescent Girls: Factors Associated with the Progression to Narcotic Use
Authors: P. Noble, G. G. Barnes
Journal: BMJ (1971)

A follow-up study of girls in a London remand home during the years 1966-8 showed that 20.6% of those taking non-narcotic drugs on admission, but only 1% of non-drug-taking control admissions, had used narcotics by June 1970. Narcotic use on admission and progression to narcotic use were associated with frequent drug taking, marked involvement in a drug milieu, and a high incidence of personal morbidity. Adolescents who use illicit drugs and have a history of court appearances for any reason are particularly vulnerable to subsequent narcotic usage and other forms of serious drug abuse.
Artefacts in Measurement of Blood Pressure and Lack of Target Organ Involvement in the Assessment of Patients with Treatment-Resistant Hypertension
Authors: Agnes D. Mejia
Journal: Annals of Internal Medicine (1990)

Objective: To determine the relative importance of factors known to cause therapy-resistant hypertension, and to derive an efficient approach to the evaluation of this problem in clinical practice. Design: Consecutive sample. Setting: University hospital hypertension clinic and clinical research center. Patients: Fifteen patients referred for management of refractory hypertension and found to have a seated diastolic blood pressure greater than 95 mm Hg while taking a standard dose of hydrochlorothiazide, propranolol, and hydralazine or its equivalent for at least 4 weeks. Measurements and Main Results: Seven patients (group 1) had normal, resting mean intra-arterial blood pressure (mean pressure < 107 mm Hg) and eight had elevated pressure (group 2). Patients in group 1 had minimal or no target organ involvement whereas those in group 2 had higher minimum vascular resistance by forearm plethysmography and greater interventricular septal wall thickness. Factors contributing to resistant hypertension, particularly in group 1, were "office hypertension" (clinic systolic blood pressure at least 20 mm Hg higher than home systolic blood pressure), pseudohypertension (cuff diastolic blood pressure at least 15 mm Hg higher than simultaneously determined intra-arterial pressure), and "cuff-inflation hypertension" (intra-arterial diastolic blood pressure rise of at least 15 mm Hg during cuff inflation). Conclusion: Home blood pressure monitoring and echocardiography are recommended as initial steps in the evaluation of patients with resistant hypertension. Intra-arterial blood pressure measurement is particularly helpful in patients with resistant hypertension who do not have office hypertension yet have normal septal thickness on echocardiography.
Significance of Folate Receptor Alpha and Thymidylate Synthase Protein Expression in Patients with Non–Small-Cell Lung Cancer Treated with Pemetrexed
Authors: Daniel C. Christoph, Bernadette Reyna Asuncion, Biftu Hassan, Cindy Tran, Julia D. Maltzman, Daniel J. O’Shannessy, Murry W. Wynes, Thomas C. Gauler, Jeremias Wohlschlaeger, Mathias Hoiczyk, Martin Schuler, Wilfried E. Eberhardt, Fred R. Hirsch
Journal: Journal of Thoracic Oncology (2012)
Topical isotretinoin in Darier's disease
Authors: S.M. BURGE, P.K. BUXTON
Journal: British Journal of Dermatology (1995)

Journal Article Topical isotretinoin in Darier's disease Get access S.M. BURGE, S.M. BURGE Departments of Dermatology, Stoke Mandeville Hospital NHS Trust, Aylesbury, Bucks HP21 8AL U.K. Search for other works by this author on: Oxford Academic Google Scholar P.K. BUXTON P.K. BUXTON The University of Edinburgh, Royal Infirmary, Edinburgh, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 133, Issue 6, 1 December 1995, Pages 924–928, https://doi.org/10.1111/j.1365-2133.1995.tb06927.x Published: 01 December 1995 Article history Accepted: 20 February 1995 Published: 01 December 1995
Aneuploidy as a mechanism for stress-induced liver adaptation
Authors: Andrew W. Duncan, Amy E. Hanlon Newell, Weimin Bi, Milton J. Finegold, Susan B. Olson, Arthur L. Beaudet, Markus Grompe
Journal: Journal of Clinical Investigation (2012)

Over half of the mature hepatocytes in mice and humans are aneuploid and yet retain full ability to undergo mitosis. This observation has raised the question of whether this unusual somatic genetic variation evolved as an adaptive mechanism in response to hepatic injury. According to this model, hepatotoxic insults select for hepatocytes with specific numerical chromosome abnormalities, rendering them differentially resistant to injury. To test this hypothesis, we utilized a strain of mice heterozygous for a mutation in the homogentisic acid dioxygenase (Hgd) gene located on chromosome 16. Loss of the remaining Hgd allele protects from fumarylacetoacetate hydrolase (Fah) deficiency, a genetic liver disease model. When adult mice heterozygous for Hgd and lacking Fah were exposed to chronic liver damage, injury-resistant nodules consisting of Hgd-null hepatocytes rapidly emerged. To determine whether aneuploidy played a role in this phenomenon, array comparative genomic hybridization (aCGH) and metaphase karyotyping were performed. Strikingly, loss of chromosome 16 was dramatically enriched in all mice that became completely resistant to tyrosinemia-induced hepatic injury. The frequency of chromosome 16–specific aneuploidy was approximately 50%. This result indicates that selection of a specific aneuploid karyotype can result in the adaptation of hepatocytes to chronic liver injury. The extent to which aneuploidy promotes hepatic adaptation in humans remains under investigation.
Quantitative Gene Expression Deregulation in Mantle-Cell Lymphoma: Correlation With Clinical and Biologic Factors
Authors: Dirk Kienle, Tiemo Katzenberger, German Ott, Doreen Saupe, Axel Benner, Holger Kohlhammer, Thomas F.E. Barth, Sylvia Höller, Jörg Kalla, Andreas Rosenwald, Hans Konrad Müller-Hermelink, Peter Möller, Peter Lichter, Hartmut Döhner, Stephan Stilgenbauer
Journal: Journal of Clinical Oncology (2007)

Purpose There is evidence for a direct role of quantitative gene expression deregulation in mantle-cell lymphoma (MCL) pathogenesis. Our aim was to investigate gene expression associations with other pathogenic factors and the significance of gene expression in a multivariate survival analysis. Patients and Methods Quantitative expression of 20 genes of potential relevance for MCL prognosis and pathogenesis were analyzed using real-time reverse transcriptase polymerase chain reaction and correlated with clinical and genetic factors, tumor morphology, and Ki-67 index in 65 MCL samples. Results Genomic losses at the loci of TP53, RB1, and P16 were associated with reduced transcript levels of the respective genes, indicating a gene-dosage effect as the pathomechanism. Analysis of gene expression correlations between the candidate genes revealed a separation into two clusters, one dominated by proliferation activators, another by proliferation inhibitors and regulators of apoptosis. Whereas only weak associations were identified between gene expression and clinical parameters or blastoid morphology, several genes were correlated closely with the Ki-67 index, including the short CCND1 variant (positive correlation) and RB1, ATM, P27, and BMI (negative correlation). In multivariate survival analysis, expression levels of MYC, MDM2, EZH2, and CCND1 were the strongest prognostic factors independently of tumor proliferation and clinical factors. Conclusion These results indicate a pathogenic contribution of several gene transcript levels to the biology and clinical course of MCL. Genes can be differentiated into factors contributing to proliferation deregulation, either by enhancement or loss of inhibition, and proliferation-independent factors potentially contributing to MCL pathogenesis by apoptosis impairment.
Time Trend Analysis of Primary Tumor Resection for Stage IV Colorectal Cancer
Authors: Chung-Yuan Hu, Christina E. Bailey, Y. Nancy You, John M. Skibber, Miguel A. Rodriguez-Bigas, Barry W. Feig, George J. Chang
Journal: JAMA Surgery (2015)

With the advent of effective modern chemotherapeutic and biologic agents, primary tumor resection for patients with stage IV colorectal cancer (CRC) may not be routinely necessary.To evaluate the secular patterns of primary tumor resection use in stage IV CRC in the United States.A retrospective cohort study using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results CRC registry. Demographic and clinical factors were compared for 64,157 patients diagnosed with stage IV colon or rectal cancer from January 1, 1988, through December 31, 2010, who had undergone primary tumor resection and those who had not. Rates of primary tumor resection and median relative survival were calculated for each year. Joinpoint regression analysis was used to determine when a significant change in trend in the primary tumor resection rate had occurred. Logistic regression analysis was used to assess factors associated with primary tumor resection.Difference in primary tumor resection rates over time.Of the 64,157 patients with stage IV CRC, 43,273 (67.4%) had undergone primary tumor resection. The annual rate of primary tumor resection decreased from 74.5% in 1988 to 57.4% in 2010 (P<.001), and a significant annual percentage change occurred between 1998-2001 and 2001-2010 (-0.41% vs -2.39%; P<.001). Factors associated with primary tumor resection were age younger than 50 years, female sex, being married, higher tumor grade, and presence of colon tumors. Median relative survival rate improved from 8.6% in 1988 to 17.8% in 2009 (P<.001); the annual percentage change was 2.18% in 1988-2001 and 5.43% in 1996-2009 (P<.001).The majority of patients with stage IV CRC had undergone primary tumor resection but, beginning in 2001, a trend toward fewer primary tumor resections was seen. Despite the decreasing primary tumor resection rate, patient survival rates improved. However, primary tumor resection may still be overused, and current treatment practices lag behind evidence-based treatment guidelines.
Appointment at the Funeral Home
Authors: Daniel M. Becker
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Graft-vs-Host Reaction Following a Single Blood Transfusion
Authors: William E. Hathaway
Journal: JAMA (1967)

The graft-vs-host (GVH) reaction occurred in an 11-month-old boy with thymic alymphoplasia and progressive vaccinia who had received a single whole blood transfusion. The principal manifestations of the GVH reaction were hepatosplenomegaly, dermatitis, diarrhea, aplastic anemia, and histiocytosis of the spleen and lymph nodes. The findings in this patient are quite similar to those of other previously reported cases of possible human runt disease. This case study emphasizes the dangers of smallpox vaccination or blood tranfusion in infants with thymic alymphoplasia or one of the variants of this syndrome.
IL-4/IL-13 antagonist DNA vaccination successfully suppresses Th2 type chronic dermatitis
Authors: T. Morioka, K. Yamanaka, H. Mori, Y. Omoto, K. Tokime, M. Kakeda, I. Kurokawa, E.C. Gabazza, A. Tsubura, Y. Yasutomi, H. Mizutani
Journal: British Journal of Dermatology (2009)

Atopic dermatitis (AD) is a chronic disease with a Th2-type-cytokine dominant profile. Several cytokines and related peptides have been used for the treatment of AD but they were ineffective because of their limited biological half-life. We have recently developed a highly efficient mouse dominant negative interleukin (IL)-4/IL-13 antagonist (IL-4DM), which blocks both IL-4 and IL-13 signal transductions.To examine the effects of IL-4DM in vivo in an AD model induced by the repeated exhibition of oxazolone (OX).Plasmid DNA was injected intraperitoneally to cause an experimental AD-like dermatitis. The effect was evaluated by ear thickness, histological findings, and mast cells counts in the inflamed skin. The plasma IgE and histamine levels were measured. Cytokine production in skin and splenocytes were also analysed.Mice treated with control plasmid developed marked dermatitis with mast cells and eosinophil infiltration, and had increased plasma IgE and histamine levels with a Th2 type splenocyte cytokine profile. Treatment with mouse IL-4 DNA augmented the ear swelling and thickness with an increased dermal eosinophil count, plasma histamine level, and production of splenocyte IL-4. However, IL-4DM treatment successfully controlled the dermatitis, decreased the mast cell and eosinophil count, and suppressed plasma IgE and histamine levels. Splenocytes produced an increased level of IFN-gamma.These data showed that the simultaneous suppression of IL-4/IL-13 signals successfully controlled Th2-type chronic dermatitis. IL-4DM DNA treatment is a potent therapy for AD and related diseases.