tbuckley/cabot-search huggingface dataset:
Abstract P1-01-19: Role of axillary clearance with tumor positive sentinel node in mastectomy group: Is the results of ACOSOG Z0011 trial adaptable to mastectomy patient?
Authors: JY You, EJ Song, MH Lee, SY Jung, SY Lee, HS Kang, ES Lee
Journal: Cancer Research (2013)

Abstract Background: Recent data from ACOSOG Z0011 trial or AMAROS trial suggest that axillary lymph node dissection(ALND) may be unnecessary for patients with positive sentinel lymph node biopsy(SLNB) receiving breast conserving surgery(BCS) with irradiation. However, consensus statements and guidelines until recently recommended that patients with mastectomy and tumor positive sentinel node undergo completion ALND. In this preliminary study, we compared these patients who did not undergo ALND with the patients who received BCS with SLNB only and irradiation and we analyzed the locoregional recurrence rate to show no differences of outcomes between two groups. Method: We identified 6,163 women with invasive breast cancer who underwent surgical resection at the National Cancer Center (Goyang,Gyeonggi-do,Korea) between January 2000 to December 2011. Clinico-pathological data obtained from prospective collecting medical database of our institution were analyzed retrospectively. The mastectomy with positive SLNB group was 47 patients and BCS with positive SLNB and irradiation group was 172 patients. The primary end point was loco-regional recurrence rate. Result : Clinical and tumor characteristics were similar between two groups except T stage and receptor status. The mean tumor size was 5.5cm with mastectomy group and 3.5cm with BCS group. The median number of nodes removed was three. There was not a single case of locoregional recurrence in both groups. At a median follow-up of 53.5 months (last follow-up, May 2013), 5-year overall survival was 85.7% with mastectomy and 97.3% with BCS group. Conclusion : In our study, there was no case of locoregional recurrence as above. This results lend weight to the argument that SLNB without ALND may be reasonable management for selected patients with appropriate surgery and adjuvant systemic therapy. This study can be regarded as a preliminary study with a sufficient value despite of the prognosis showed some statistical differences between two groups. It resides in the difference of initial stage of patients of two groups. We will present additional data compared with the mastectomy with axillary clearance group at the meeting. Acknowledgement This work was supported by grant from the National Cancer Center Korea (1210331-2). Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P1-01-19.
"Failure" of the random zero sphygmomanometer in general practice
Authors: B M Wright
Journal: BMJ (1985)

We also doubt whether, after missing a pill at the start of a packet, the normal practice of taking wo pills would increase the risk of ovulation.This is because a good dose of progestogen as well as oestrogen is thereby given, and Yuzpe et al have shown that a similar regimen is a good postcoital contraceptive even during spontaneous cycles.)
Transmission of avian influenza A(H7N9) virus from father to child: a report of limited person-to-person transmission, Guangzhou, China, January 2014
Authors: X C Xiao, K B Li, Z Q Chen, B Di, Z C Yang, J Yuan, H B Luo, S L Ye, H Liu, J Y Lu, Z Nie, X P Tang, M Wang, B J Zheng
Journal: Eurosurveillance (2014)

Binary file ES_Abstracts_Final_ECDC.txt matches
Cancer stem cells display extremely large evolvability: alternating plastic and rigid networks as a potential Mechanism
Authors: Peter Csermely, János Hódsági, Tamás Korcsmáros, Dezső Módos, Áron R. Perez-Lopez, Kristóf Szalay, Dániel V. Veres, Katalin Lenti, Ling-Yun Wu, Xiang-Sun Zhang
Journal: Seminars in Cancer Biology (2014)
Review: Pregabalin reduces chronic neuropathic pain in adults
Authors: Roger Chou
Journal: Annals of Internal Medicine (2009)

ACP Journal Club15 December 2009Review: Pregabalin reduces chronic neuropathic pain in adultsRoger Chou, MDRoger Chou, MDOregon Health & Science University, Portland, Oregon, USA (R.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-12-200912150-02007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationMoore RA, Straube S, Wiffen PJ, Derry S, McQuay HJ. Pregabalin for acute and chronic pain in adults. Cochrane Database Syst Rev. 2009;(3):CD007076. https://pubmed.ncbi.nlm.nih.gov/19588419Clinical Impact RatingsGIM/FP/GP: Endocrinology: Neurology: References1 Chou R, Carson S, Chan BK. Gabapentin versus tricyclic antidepressants for diabetic neuropathy and post-herpetic neuralgia: discrepancies between direct and indirect meta-analyses of randomized controlled trials. J Gen Intern Med. 2009;24:178-88. [PMID: 19089502] Google Scholar2 Baron R, Mayoral V, Leijon G, et al. Efficacy and safety of 5% lidocaine (lignocaine) medicated plaster in comparison with pregabalin in patients with postherpetic neuralgia and diabetic polyneuropathy: interim analysis from an open-label, two-stage adaptive, randomized, controlled trial. Clin Drug Investig. 2009;29:231-41. [PMID: 193019373]. Google Scholar3 Gilron I, Bailey JM, Tu D, et al. Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial. Lancet. 2009;374:1252-61. [PMID: 19796802] Google Scholar Author, Article, and Disclosure InformationAffiliations: Oregon Health & Science University, Portland, Oregon, USA (R.C.)This article was published at Annals.org on 1 December 2009. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnalgesic effect of nobiletin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice 15 December 2009Volume 151, Issue 12Page: JC6-7KeywordsAdverse eventsComparative effectiveness researchDatabasesFibromyalgiaNeuropathic painNumber needed to treatPainReuptake inhibitorsSafetyTricyclic antidepressants ePublished: 15 December 2009 Issue Published: 15 December 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 579: Cell death induction end-points to identify new cancer indications with high likelihood of response to dual PI3K /mTOR inhibitors
Authors: Alan Huang, Joseph Lehar, Elina Pradhan, Emmanuelle Di Tomaso, Maria Villarroel, Wolfgang Hackl, Cornelia Quadt, Christine Fritsch, Andreas Weiss, Saskia Brachmann, Robert Schlegel, Francesco Hofmann, Michel Maira
Journal: Cancer Research (2011)

Abstract Constitutive activation of the PI3K pathway is driven by a variety of genetic and epigenetic abnormalities, such as PTEN deletions, mutations, genesilencing, PIK3CA mutations and/or enhanced engagement through genetic abnormalities in upstream RTKs. Targeted therapies against specific components of the PI3K pathway are therefore expected to produce positive outcome as single agents or in combination in cancers presenting these abnormalities. Two molecular entities are in full clinical development: NVP-BEZ235, a dual PI3K/mTOR inhibitor and NVP-BKM120, a pan-class I PI3K inhibitor without mTOR activity. In order to best position these agents clinically, we investigated their efficacy in models bearing PIK3CA, PTEN, HER2, or KRAS genetic alterations. We previously demonstrated that NVP-BEZ235 in in vitro antiproferative activity was not predictive of preclinical antitumor response, in vivo. However, breast cancer models presenting either HER2 amplification or PIK3CA mutations or both were shown to be very sensitive to the compound and the use of cell death induction as an end-point was found to be predictive of strong antitumor activity in vivo. To further validate this finding, dual PI3K/mTOR targeting was phenocopied using an mTOR shRNA inducible system or an mTOR specific inhibitor (AZD8055) in combination with a pan-PI3K inhibitor, in various tumor models. Strong cell death signals were observed in 2 HER2 amplified / PIK3CA mutant breast cancer models but not in KRAS mutant cells or as PTEN silenced breast cancer cell lines, when subjected of PI3K/mTOR targeting. Moreover, in vivo, combination of a pure pan-PI3K with a pure mTOR inhibitor resulted in strong regression of HER2 amplified /PIK3CA mutant MDA-MB361 tumors.On the basis of these observations, NVP-BEZ235 was retested in a set of more then 150 tumor lines across various lineages, and cell death induction was determined. As expected, HER2 amplified /PIK3CA mutant breast cancer lines scored as sensitive. Other models from different indications and genetic background were also found to be sensitive to NVP-BEZ235. Validation studies of these new models and potential indications will be presented, and implications for further clinical trials of dual PI3K/mTOR or pure PI3K inhibitors discussed. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 579. doi:10.1158/1538-7445.AM2011-579
HBV DNA persistence 10 years after liver transplantation despite successful anti-HBS passive immunoprophylaxis
Authors: Bruno Roche, Cyrille Feray, Michele Gigou, Anne Marie Roque-Afonso, Jean Louis Arulnaden, Valerie Delvart, Elisabeth Dussaix, Catherine Guettier, Henri Bismuth, Didier Samuel
Journal: Hepatology (2003)

Long–term immunoprophylaxis with hepatitis B immune globulin (HBIG) is widely accepted for the prevention of recurrent hepatitis B virus (HBV) infection after liver transplantation in HBV–infected patients without viral replication. We report long–term results of HBIG administration in 284 hepatitis B surface antigen (HBsAg)–positive transplant patients. In protocol 1, 259 patients were given HBIG with the goal of maintaining the anti–HBs antibody (Ab) titer over 100 IU/L. After December 1993, 25 HBV DNA–positive patients received HBIG, with a target anti–HBs Ab titer over 500 IU/L, combined with posttransplantation antiviral therapy (protocol 2). At 10 years, 44 patients without recurrence were tested for the presence of HBV DNA in serum using real–time polymerase chain reaction (PCR); 28 were also tested in liver and peripheral blood mononuclear cells (PBMC). The overall 5– and 10–year posttransplantation actuarial rates of HBV recurrence were 24.2% and 25.4%, respectively. The 5–year recurrence rate in protocol 2 patients was 11.8%. On multivariate analysis, predictors of lower HBV recurrence risk were absence of serum HBV DNA before transplantation ( P &lt; .0001), acute liver disease ( P = .0037), HDV superinfection ( P = .012), and protocol 2 therapy ( P &lt; .0001). Low–level HBV DNA was detected by PCR in 45.4% of patients without HBV recurrence at 10 years. Overall actuarial 10–year survival was 74.4%. In conclusion, we confirm the efficacy of long–term HBIG immunoprophylaxis. Combination prophylaxis with HBIG and antiviral therapy is effective in patients with viral replication. Although there were only a few cases of HBV recurrence after 5 years, HBV DNA remained present in 45% of patients at 10 years.
SANITATION ON THE RIVIERA
Authors: C. R. Kilkelly
Journal: BMJ (1930)

<h3>Abstract</h3> Visual knowledge obtained from our lifelong experience of the world plays a critical role in our ability to build short-term memories. We propose a mechanistic explanation of how working memories are built from the latent representations of visual knowledge and can then be reconstructed. The proposed model, Memory for Latent Representations (MLR), features a variational autoencoder with an architecture that corresponds broadly to the human visual system and an activation-based binding pool of neurons that binds items’ attributes to tokenized representations. The simulation results revealed that the shapes of familiar items can be encoded and retrieved efficiently from latents in higher levels of the visual hierarchy. On the other hand, novel patterns that are completely outside the training set can be stored from a single exposure using only latents from early layers of the visual system. Moreover, a given stimulus in working memory can have multiple codes, representing specific visual features such as shape or color, in addition to categorical information. Finally, we validated our model by testing a series of predictions against behavioral results obtained from WM tasks. The model provides a compelling demonstration of how visual knowledge yields compact visual representation for efficient memory encoding.
The Hepatitis of Hyperthermia
Authors: Joseph H. Bragdon
Journal: New England Journal of Medicine (1947)

PATIENTS receiving intensive artificial fever therapy occasionally develop jaundice. This phenomenon has recently been reported as a major complication of therapeutic hyperthermia by several different groups of observers.1 2 3 In the reported series the incidence of jaundice has been as high as 19 per cent.3 The jaundiced patients follow a characteristic clinical course. Usually within the first twenty-four hours following fever, exaggerated nausea and vomiting occur. Within forty-eight hours the urine is dark and jaundice becomes apparent. There may be upper abdominal discomfort and tenderness over the liver. Fever, if present, is slight. In the great majority of cases the jaundice . . .
Rehabilitation after stroke: summary of NICE guidance
Authors: K. Dworzynski, G. Ritchie, E. Fenu, K. MacDermott, E. D. Playford
Journal: BMJ (2013)

Each year, about 150 000 people in the UK have a first or recurrent stroke.1 Despite UK health policies that place a great emphasis on reducing stroke (such as the National Stroke Strategy2) and improvements in mortality and morbidity, guidance is needed on access to and provision of effective rehabilitation services to maximise quality of life after stroke. This article summarises the most recent recommendations from the National Institute for Health and Care Excellence (NICE) on long term rehabilitation after stroke.3

NICE recommendations are based on systematic reviews of the best available evidence and explicit consideration of cost effectiveness. When minimal evidence is available, recommendations can be based on the Guideline Development Group’s experience and opinion of what constitutes good practice. Evidence levels for the recommendations are given in italic in square brackets.

### Organising rehabilitation and care for people with stroke

Rehabilitation may take place in a variety of settings—in hospital, in outpatient clinics, in the community, and in individuals’ own homes.

### Planning and delivering stroke rehabilitation

To ensure the safety of the person with stroke while maintaining a patient centred approach, key processes need to be in place. These processes include assessment on admission …
Angiotensin converting enzyme: a tumour marker in malignant histiocytosis.
Authors: F Boomsma, J J Michiels, E Prins, J Abels, M A Schalekamp
Journal: BMJ (1983)

Angiotensin converting enzyme: a tumour marker in malignant histiocytosisAngiotensin converting enzyme is present in vascular endothelial cells and in cells of the monocyte macrophage series.Serum activities of the enzyme may be raised in active sarcoidosis, Gaucher's disease, leprosy, asbestosis, and silicosis,' in hyperthyroidism,2 and in alcoholic liver disease and diabetes mellitus with severe retinopathy.3Low serum activities of the enzyme have been reported in lung cancer, malignant lymphoma, leukaemia, and multiple myeloma.4We report raised activities of the enzyme in two patients with malignant histiocytosis (histiocytic medullary reticulosis).5Case reports Case 1-A 52 year old man was referred to our hospital because of sustained fever, weight loss, progressive hepatosplenomegaly, and jaundice.Laboratory values were haemoglobin concentration 4-8 mmol/l (7.7 g/dl), platelet count
Magnesium suppression of early afterdepolarizations and ventricular tachyarrhythmias induced by cesium in dogs.
Authors: D S Bailie, H Inoue, S Kaseda, J Ben-David, D P Zipes
Journal: Circulation (1988)

The mechanism by which magnesium therapy suppresses some ventricular tachyarrhythmias characterized by a prolonged QT interval (e.g., torsades de pointes) is unknown. Since early afterdepolarizations have been proposed as a cause of the long QT syndrome and the related ventricular tachyarrhythmias, we hypothesized that magnesium therapy would suppress both the early afterdepolarizations and the ventricular arrhythmias. The present study was performed to test that hypothesis. Using monophasic action potentials (MAP) recorded with a contact electrode from the right ventricular endocardium to demonstrate early afterdepolarizations, cesium chloride (168 mg/kg iv) was administered before, during, and 1 to 2 hr after discontinuation of a magnesium infusion (1 to 2 mg/kg/min for 20 to 30 min). Before magnesium infusion, cesium induced early afterdepolarizations that were 49.7 +/- 1.6% (mean +/- SE) of the amplitude of the corresponding monophasic action potential. The amplitude of the early afterdepolarization decreased to 31.2 +/- 3.8% of the MAP amplitude during magnesium infusion (p less than .003) and increased to 48.0 +/- 4.0% 1 to 2 hr after termination of the magnesium infusion (p less than .003). Cesium induced sustained monomorphic ventricular tachycardia, torsades de pointes, or ventricular fibrillation in 12 of 13 dogs before magnesium infusion, and in eight of 11 dogs 1 to 2 hr after stopping infusion, but in only three of 13 dogs during magnesium infusion. Cesium prolonged the corrected QT interval from 338 +/- 16 msec (control) to 387 +/- 14 msec before (p less than .003), 356 +/- 12 msec during (p less than .003), and 406 +/- 16 msec after stopping the magnesium infusion (p less than .003).(ABSTRACT TRUNCATED AT 250 WORDS)
A New Form of Hereditary Kyphoscoliosis.
Authors: Charles J. Epstein
Journal: Annals of Internal Medicine (1965)

s1 May 1965A New Form of Hereditary Kyphoscoliosis.Charles J. Epstein, M.D., William E. Hodgkin, M.D., Fredrick Hecht, M.D., C. Benjamin Graham, M.D., Arno G. Motulsky, M.D., F.A.C.P.Charles J. Epstein, M.D.Search for more papers by this author, William E. Hodgkin, M.D.Search for more papers by this author, Fredrick Hecht, M.D.Search for more papers by this author, C. Benjamin Graham, M.D.Search for more papers by this author, Arno G. Motulsky, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1096_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA 39-year-old man and his 15-month-old son have been under investigation for a dominantly inherited musculoskeletal disorder. The father has been markedly dwarfed since childhood as the result of a very severe kyphoscoliosis. In addition, he manifests (1) flexion contractures of several joints, particularly in the hands; (2) thin extremities with poorly developed musculature; (3) long slender fingers and toes ("arachnodactyly"); and (4) abnormally formed external ears. Shortly after birth, the patient's son was noted to have all of the enumerated features, and over the course of a year has progressively developed a moderately severe kyphoscoliosis. At the age of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, Washington PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1096-1097KeywordsBirth Issue Published: 1 May 1965 PDF DownloadLoading ...
Defense of Friedmann's Treatment for Tuberculosis
Authors: Arthur C. H. Friedmann
Journal: JAMA (1913)

<h3>To the Editor</h3> —It is only with the greatest hesitancy and decidedly against my own preference that I am addressing you in regard to two editorial comments in The Journal of Dec. 14, 1912 ("Friedmann's Inoculation Against Tuberculosis," p. 2158, and "Responsibility of the Newspaper," p. 2159). But as I am the brother of Frederick Franz Friedmann of Berlin, whose ethics you assail in the above mentioned issue, and as I have been a member of the American Medical Association for many years, I believe it to be my privilege, and my duty at the same time, to come to the rescue of one who is too busy and too far away to defend himself. As to the "secrecy" of the process by which virulent live bacilli are made avirulent without losing their vitality, and which "secrecy" you call not in accord with the ethical standard of scientific medicine: can
Hemoglobin Brigham (α2Aβ2100 Pro→Leu). HEMOGLOBIN VARIANT ASSOCIATED WITH FAMILIAL ERYTHROCYTOSIS
Authors: Jacob J. Lokich, William C. Moloney, H. Franklin Bunn, Sally M. Bruckheimer, Helen M. Ranney
Journal: Journal of Clinical Investigation (1973)

Erythrocytosis associated with the presence of a hemoglobin with increased oxygen affinity has been reported for 10 hemoglobin variants, most of which demonstrate altered electrophoretic mobility. Several members of a family were found to have erythrocytosis, and both the whole blood and the hemoglobin exhibited increased oxygen affinity. Phosphate-free hemoglobin solutions had a normal Bohr effect and reactivity to 2,3-diphosphoglycerate. The electrophoretic properties of the hemoglobin were normal, but on peptide mapping of a tryptic digest of the isolated β-chains, a normal βT11 peptide and an abnormal βT11 with greater Rf were seen. Analysis of the abnormal peptide showed the substitution of leucine for the normal proline at β100 (helical residue G2).
Induction of preadipocyte differentiation by mature fat cells in the rat.
Authors: G Shillabeer, J M Forden, D C Lau
Journal: Journal of Clinical Investigation (1989)

In this study we investigated the influence of mature adipocytes, derived from rat adipose tissue, on the replication and differentiation of preadipocytes in primary culture. Mature fat did not inhibit preadipocyte replication within the 6-d period studied. Preadipocyte differentiation, as assessed by both cytoplasmic lipid accretion and an increase in glycerophosphate dehydrogenase (GPDH) activity, was significantly stimulated by the presence of mature fat tissue or isolated adipocytes. The proportion of cells containing visible lipid droplets by oil red O staining was 47 +/- 10 to 58 +/- 10% (depending on the site of origin of the preadipocytes) when cocultured with mature fat compared with less than 1 to 2 +/- 1% when cultured in medium alone, while GPDH activity was 344 +/- 9 compared with 43 +/- 3 nM NADH/min per mg protein, respectively. This effect was not due to release of triacylglycerols from damaged adipocytes. Fatty acids added to the medium promoted lipid accumulation but did not stimulate a rise in GPDH activity. We concluded that mature adipocytes may release factor(s) that promote preadipocyte differentiation (and maturation).
Doctors explain why they resigned from the NHS's IT programme
Authors: Michael Cross
Journal: BMJ (2006)

Senior doctors told MPs this week that they resigned from the programme to computerise the NHS in England after coming under pressure to exaggerate the extent of clinicians' involvement in the design of the system.

Peter Hutton, the former chief clinical adviser to the £12bn (€17bn; $22bn) programme, told MPs at a session of the House of Commons Public Accounts Committee that he had warned the NHS …