tbuckley/cabot-search huggingface dataset:
211 Adipogenic regulation of hepatic stellate cell transdifferentiation
Authors: H SHE, S HAZRA, S XIONG, J WANG, C SUNG, H TSUKAMOTO
Journal: Hepatology (2003)

The very low-density lipoprotein (VLDL) receptor is a member of the low-density lipoprotein (LDL) receptor gene family with distinct tissue distribution and function. VLDL receptors are also expressed in vascular smooth muscle cells (VSMCs) and have been shown to be upregulated in atherosclerotic lesions. In the present study, we examined the effects of interleukin-1β (IL-1β) on the uptake of βVLDL and its receptor expression in rat VSMCs. IL-1β downregulated expression of the VLDL receptor in a time and dose-dependent manner as shown by Western blotting, Northern blotting, and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. Treatment with IL-1β significantly reduced the uptake of β–VLDL but not LDL in VSMCs. Use of specific pharmacologic inhibitors indicated that the tyrosine kinase inhibitors, herbimycin A and geldanamycin, completely reversed IL-1β-induced downregulation of the VLDL receptor expression. Another tyrosine kinase inhibitor, genistein, the protein kinase C inhibitors, GF109203X and H7, the mitogen-activated protein (MAP) kinase inhibitors (MEK inhibitor PD098059 for [MEK] and SB203580 for p38-MAP kinase), and the protein kinase A inhibitor, KT5270 all had no effect on receptor expression. In addition, the c-Src specific inhibitor PP2 or adenoviral-mediated gene transfer of kinase inactive (KI)-c-Src failed to reverse IL-1β-induced downregulation of VLDL receptor expression. These results indicate that IL-1β attenuates uptake of VLDL through downregulation of its receptor in VSMCs, and that this downregulation is mediated through a benzoquinone ansamycin-dependent but c-Src-independent pathway.
Another US health system adopts "tobacco-free" hiring policy
Authors: M. McCarthy
Journal: BMJ (2013)

The University of Pennsylvania Health System (Penn Medicine) has become the latest in a growing number of US health systems that will no longer hire smokers.

Holly Auer, the system’s spokeswoman, said, “We believe that our tobacco use hiring policy will help underscore Penn Medicine’s commitment to the health and welfare of not only our patients but to our employees and the larger community across the city and state.”

The University of Pennsylvania Health System includes the Hospital of the University of Pennsylvania and the Children’s Hospital of Philadelphia, both located in Philadelphia.

Civil libertarians and unions have denounced similar tobacco-free hiring policies, saying that employers should have no say over what their employees do on their own time. And health policy analysts are concerned that such polices would simply make smokers conceal their …
Case 42-1972
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, Charles S. Davidson, James J. Galdabini
Journal: New England Journal of Medicine (1972)

Presentation of CaseA 73-year-old woman was admitted to the hospital because of fever.She had been well until four years previously, when abdominal swelling and peripheral edema developed. Examination disclosed hepatic enlargement and ascites. The hematocrit was 27 per cent. A stool specimen gave a + test for occult blood. The bilirubin was 0.8 mg, the iron 87 μg, the iron-binding capacity 166 μg, the ammonia 100 to 150 μg, and the protein 5.1 g (the albumin 2.5 g, and the globulin 2.6 g) per 100 ml. The glutamic oxalacetic transaminase (SGOT) was 47 U, and the alkaline phosphatase . . .
Transient Ischemic Attack after Air-Contrast Echocardiography
Authors: Howard C. Dittrich
Journal: Annals of Internal Medicine (1995)

Letters1 November 1995Transient Ischemic Attack after Air-Contrast EchocardiographyHoward C. Dittrich, MDHoward C. Dittrich, MDUniversity of California, San Diego; San Diego, CA 92103Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-9-199511010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest the recent letter from Drs. Srivastava and Undesser [1] discussing the occurrence of two transient ischemic attacks from among 46 patients having contrast studies with echocardiography using 10 mL of agitated air and normal saline.We see many patients with severe chronic pulmonary artery hypertension who are referred for pulmonary thromboendarterectomy. Many of these patients have pulmonary artery pressures near systemic levels, substantial tricuspid regurgitation, and elevated right atrial pressures. These patients have routine contrast echocardiography as part of their preoperative evaluation to determine the presence of patent foramen ovale. If detected, the ...References1. Srivastava TN, Undesser EK. Transient ischemic attack after air contrast echocardiography in patients with septal aneurysm [Letter]. Ann Intern Med. 1995; 122:396. Google Scholar2. Dittrich HC, McCann HA, Wilson WW, Mitchell M, Jamieson SW, Auger WR, et al. Identification of interatrial communication in patients with elevated right atrial pressure using surface and transesophageal contrast echocardiography [Abstract]. J Am Coll Cardiol. 1993; 21:135A. Google Scholar3. Crouse LJ, Cheirif J, Hanly DE, Kisslo JA, Labovitz AJ, Raichlen JS, et al. Opacification and border delineation improvement in patients with suboptimal endocardial border definition in routine echocardiography: results of the phase II Albunex multicenter trial. J Am Coll Cardiol. 1993; 22:1494-500. Google Scholar4. Aronson S, Fernandez A, Karp R, Lee B, Windelmann J, Feinstein S. Aortic root injection of Albunex in patients undergoing coronary artery bypass surgery: safety and efficacy. J Am Soc Echocardiogr. 1994; 7:S30. Google Scholar Author, Article, and Disclosure InformationAuthors: Howard C. Dittrich, MDAffiliations: University of California, San Diego; San Diego, CA 92103 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAgitated Blood-Saline Rather Than Agitated Air-Saline for Echocardiographic Shunt StudiesSafety of Ultrasound Contrast Agents in Patients With Known or Suspected Cardiac Shunts 1 November 1995Volume 123, Issue 9 Page: 731-732 Keywords Echocardiography Left atrium Lungs Patient advocacy Pulmonary arteries Pulmonary hypertension Safety Saline solutions Transient ischemic attacks Ultrasound imaging ePublished: 15 August 2000 Issue Published: 1 November 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Hypoprothrombinemia as a Complication of Propylthiouracil
Authors: Donald K. Gilbert
Journal: JAMA (1964)

PROPYLTHIOURACIL is of recognized value in the therapy of hyperthyroidism and the various adverse reactions to it have been thoroughly reviewed. Leukopenia and agranulocytosis are the most prominent hematologic reactions. In addition, purpura has been described. Severe hypoprothrombinemia and resultant bleeding is a rare complication of propylthiouracil, only six cases having been reported. Deficiency of several coagulation factors have been incriminated as the underlying mechanism. The patient to be presented represents an additional example of this phenomenon. <h3>Report of a Case</h3> The diagnosis of diffuse toxic goiter was made on a 27-year-old white housewife in January, 1964. The 24-hour uptake of radioactive iodine (I<sup>131</sup>) was 84%. A radioscan of the thyroid revealed diffuse, non-nodular enlargement. As preparation for thyroidectomy, propylthiouracil was administered in dosage of 100 mg every eight hours for 13 days. This was followed by a dosage of 100 mg every six hours for 17 days and
Fatal pulmonary aspiration of oral activated charcoal.
Authors: D. G. Menzies, A. Busuttil, L. F. Prescott
Journal: BMJ (1988)

correct, as the plasma concentration of vitamin A is closely controlled.The multi-infarct group had an -intermediate mean plasma carotene concentration and showed no significant correlation between plasma carotene and plasma vitamin A concentrations (Spearman coefficient 0 32).These findings very probably result from including patients who also have Alzheimer's disease in the multi-infarct group.5The cause of carotenaemia in Alzheimer's disease is unclear.Although there is considerable overlap with other groups, increased plasma carotene con- centrations may be useful as a diagnostic criterion for Alzheimer's disease.
ABORTION DUE TO SUPERFETATION
Authors: A. L. Gustetter
Journal: JAMA (1918)

There would be no way of controlling or of preventing abortion in the event of the implantation of a second fetus in a uterus already occupied by one in a process of development, even if the condition were known to exist. The case herewith reported is of great interest, nevertheless, as demonstrating that abortion or miscarriage may be produced by superfetation. It might even be a frequent, though often overlooked, cause. Mrs. M. G., aged 22, of previous healthy condition, menstruated regularly and normally prior to marriage. The first child, born May 7, 1916, and the second child, born April 10, 1917, were delivered normally. Following the birth of the second child, menstruation began during the latter part of May, continued for fifteen days, and was irregular in quantity. During the latter part of July the patient began to menstruate again, and complained of a severe pain over and on
Health: A Matter of Statistics or Feeling?
Authors: F. J. Ingelfinger
Journal: New England Journal of Medicine (1977)

Lawrence Henderson, world-famous biochemist, also admonished physicians to become more aware of the sociologic adversities of their patients,1 tasted wines while he elaborated on the virtues of a certain side of a certain hill of a certain vineyard, and framed quotable bon mots. A Henderson aphorism frequently cited was attributed to him by Dr. Herrman Blumgart: "Somewhere between 1910 and 1912 in this country,... a random patient, with a random disease, consulting a doctor chosen at random had, for the first time in the history of mankind, a better than fifty-fifty chance of profiting from the encounter."2 Henderson's words imply . . .
Hematopoietic cell transplantation from HLA-identical sibling donors after low-dose radiation-based conditioning for treatment of CML
Authors: F R Kerbauy, R Storb, U Hegenbart, T Gooley, J Shizuru, H K Al-Ali, J P Radich, D G Maloney, E Agura, B Bruno, E M Epner, T R Chauncey, K G Blume, D Niederwieser, B M Sandmaier
Journal: Leukemia (2005)
Isolation of<i>Borrelia afzelii</i>from circumscribed scleroderma
Authors: F H Breier, E Aberer, G Stanek, G Khanakaha, A Schlick, G Tappeiner
Journal: British Journal of Dermatology (1999)

Journal Article Isolation of Borrelia afzelii from circumscribed scleroderma Get access F H Breier, F H Breier Department of Dermatology, Lainz Municipal Hospital, Wolkersbergenstr. 1, A‐1130 Vienna, Austria, Search for other works by this author on: Oxford Academic Google Scholar E Aberer, E Aberer Department of Dermatology, University of Vienna, Austria, Search for other works by this author on: Oxford Academic Google Scholar G Stanek, G Stanek Hygiene Institute, University of Vienna, Austria Search for other works by this author on: Oxford Academic Google Scholar G Khanakaha, G Khanakaha Hygiene Institute, University of Vienna, Austria Search for other works by this author on: Oxford Academic Google Scholar A Schlick, A Schlick Hygiene Institute, University of Vienna, Austria Search for other works by this author on: Oxford Academic Google Scholar G Tappeiner G Tappeiner Department of Dermatology, University of Vienna, Austria, Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 140, Issue 5, 1 May 1999, Pages 925–930, https://doi.org/10.1046/j.1365-2133.1999.02828.x Published: 01 May 1999
DNA rearrangement and restriction fragment length polymorphism within the first <i>BCR</i> intron in philadelphia‐positive acute leukemia
Authors: Yuichi Nakamura, Osamu Miura, Yuichi Sugahara, Nobuo Maseki, Yasuhiko Kaneko, Nobuo Aoki
Journal: American Journal of Hematology (1989)

Abstract In some patients with Philadelphia (Ph)‐chromosome positive acute lymphoblastic leukemias, breakpoints on chromosome 22 are reported to occur within the first BCR intron. To analyze the breakpoints in chromosome 22 of Ph‐positive acute leukemia patients without rearrangement of the 5.8 kb bcr , we cloned the 3′ part of the first BCR intron using a synthetic DNA probe. During the course of study, we mapped the region of the deletion/insertion of 1 kb that causes a restriction fragment length polymorphism (RFLP) and found a racial difference in the frequencies of the alleles giving rise to this RFLP. Analyses of the patients' samples indicated that breakpoints were located within the 8.5 kb Eco RI fragment of the first BCR intron in two of five Ph‐positive acute leukemia patients. The data, together with the previous reports, indicate that breakpoints within this ∼50 kb intron are widely scattered, in contrast to those confined within the 5.8 kb bcr in chronic myelogenous leukemias.
Identification of Warthin??s Tumor with Technetium-99m Pertechnetate
Authors: TOMOMITSU HIGASHI, HIDEO MURAHASHI, HIROYUKI IKUTA, YUTAKA MORI, YOSHIHISA WATANABE
Journal: Clinical Nuclear Medicine (1987)

Salivary gland imaging with Tc-99m pertechnetate is a useful procedure for evaluating the functional status of salivary glands. The only neoplasms of salivary glands known to consistently concentrate Tc-99m pertechnetate are Warthin's tumor and oncocytoma. In the five cases presented, increased concentration of Tc-99m pertechnetate was seen in these tumors of the parotid glands. This finding was useful for preoperative identification of Warthin's tumor. During this investigation, the concentration of Tc-99m pertechnetate in Warthin's tumor varied by histologic type. Thus, a dynamic study may be helpful in evaluating the accumulation rate of Tc-99m pertechnetate into this tumor type. Because the retention of Tc-99m pertechnetate in tumor following stimulation is useful for the diagnosis of Warthin's tumor, a washout image is of importance in establishing this diagnosis.
Pharmacologically Increased Tumor Hypoxia Can Be Measured by 18F-Fluoroazomycin Arabinoside Positron Emission Tomography and Enhances Tumor Response to Hypoxic Cytotoxin PR-104
Authors: Rob A. Cairns, Kevin L. Bennewith, Edward E. Graves, Amato J. Giaccia, Daniel T. Chang, Nicholas C. Denko
Journal: Clinical Cancer Research (2009)

Solid tumors contain microenvironmental regions of hypoxia that present a barrier to traditional radiotherapy and chemotherapy, and this work describes a novel approach to circumvent hypoxia. We propose to overcome hypoxia by augmenting the effectiveness of drugs that are designed to specifically kill hypoxic tumor cells.We have constructed RKO colorectal tumor cells that express a small RNA hairpin that specifically knocks down the hypoxia-inducible factor 1a (HIF1a) transcription factor. We have used these cells in vitro to determine the effect of HIF1 on cellular sensitivity to the hypoxic cytotoxin PR-104, and its role in cellular oxygen consumption in response to the pyruvate dehydrogenase kinase inhibitor dichloroacetate (DCA). We have further used these cells in vivo in xenografted tumors to determine the role of HIF1 in regulating tumor hypoxia in response to DCA using (18)F-fluoroazomycin arabinoside positron emission tomography, and its role in regulating tumor sensitivity to the combination of DCA and PR-104.HIF1 does not affect cellular sensitivity to PR-104 in vitro. DCA transiently increases cellular oxygen consumption in vitro and increases the extent of tumor hypoxia in vivo as measured with (18)F-fluoroazomycin arabinoside positron emission tomography. Furthermore, we show that DCA-dependent alterations in hypoxia increase the antitumor activity of the next-generation hypoxic cytotoxin PR-104.DCA interferes with the HIF-dependent "adaptive response," which limits mitochondrial oxygen consumption. This approach transiently increases tumor hypoxia and represents an important method to improve antitumor efficacy of hypoxia-targeted agents, without increasing toxicity to oxygenated normal tissue.
Psychopharmacology: A Generation of Progress
Authors: Alan L. Krueger
Journal: JAMA (1978)

Through an ad hoc committee, the American College of Neuropsychopharmacology has reviewed the last decade of neuropsychopharmacological research and clinical practice. This survey has resulted in a collection of papers from many of the outstanding contributors to the field. The resulting textbook,<i>Psychopharmacology: A Generation of Progress</i>, could easily be the most thorough reference text on the subject. The table of contents alone is 11 pages long and outlines the last ten years of experience. An advantage of this text is its universal utility. Current research data are easily retrievable for the basic scientist, and practical applications of psychopharmacology are reviewed for the clinician. The collection begins with a historical overview of neuropsychopharmacology and a discussion of the ethical and methodological issues in this area of research and treatment. Subsequent articles review the mechanisms of drug actions on a molecular level, followed by sections reviewing animal experimentation and human studies
Advantages of Brief Psychotherapy.
Authors: Frederick Lemere
Journal: Annals of Internal Medicine (1967)

s1 May 1967Advantages of Brief Psychotherapy.Frederick Lemere, M.D., F.A.C.P.Frederick Lemere, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1067_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptProlonged intensive psychotherapy in depth was once considered to be the ideal goal of the therapeutic endeavor. Anything short of this was thought to be inadequate or expedient. Fortunately this concept is no longer valid, as the results with brief therapy are often as good or better and are now scientifically acceptable. Although psychoanalytic-type therapy is occasionally indicated and necessary, its general application tends to limit the range and scope of treatment. Internists can and should have more confidence in their own common-sense approach to the emotional ills of their patients.The technique of brief psychotherapy is described. It consists... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Seattle, Washington PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1967Volume 66, Issue 5Page: 1067-1068KeywordsEmotions Issue Published: 1 May 1967 PDF DownloadLoading ...
Gallbladder Metastasis From Malignant Melanoma: Diagnosis With FDG PET/CT
Authors: Bhavya Rehani, Pamela Strohmeyer, Martin Jacobs, Joseph Mantil
Journal: Clinical Nuclear Medicine (2006)

Melanoma with metastasis to the gallbladder is sometimes seen on autopsy but is rarely seen in living patients, in part because it is often asymptomatic. A 67-year-old man with a history of malignant melanoma in situ underwent an F-18 FDG PET/CT scan, which showed a gallbladder focus (SUV 16.9). Four months later, on the repeat FDG PET/CT scan, a new lesion in the gallbladder was noted. Laparoscopic cholecystectomy was done and histopathologic findings were consistent with gallbladder metastasis of melanoma. PET/CT detects metastasis at unusual sites accurately and is helpful in correct staging and management of patients with melanoma.
Lean body mass, gastric acid, and peptic ulcer
Authors: J. H. Baron
Journal: Gut (1969)

Peak acid outputs in normal subjects and patients with duodenal and gastric ulcer were significantly (and similarly) correlated with body weight and calculated lean body mass. Expression of measurements of peak acid output as a function of body weight or lean body mass lessened but did not abolish the significance of the situation that men with no dyspepsia or gastric ulcer secreted more acid than women; the significant sex difference in duodenal ulcer was, however, abolished. Data for peak acid output have been tabulated, not only as m-equiv/hr but also as mu-equiv/kg body weight/hr and mu-equiv/kg lean body mass/hr. On the basis of the present data no change is suggested in the current expression of peak acid output as m-equiv/hr since expression of acid output as a function of body weight or lean body mass improves neither the variability nor the diagnostic discrimination of measurement of peak acid output.
Prevalence of Genetic Hemochromatosis in a Cohort of Italian Patients with Diabetes Mellitus
Authors: Dario Conte
Journal: Annals of Internal Medicine (1998)

Background: Few data exist on the prevalence of genetic hemochromatosis among diabetic patients. Objective: To compare the prevalence of genetic hemochromatosis in diabetic patients and a matched control group and to evaluate the accuracy of iron-related indexes in detecting hemochromatosis. Design: Cross-sectional study. Setting: Diabetes clinics of four hospitals in northern Italy. Patients: 894 diabetic patients (117 with type 1 diabetes and 777 with type 2 diabetes) and 467 matched controls. Measurements: Transferrin saturation and serum ferritin levels were measured in all study participants. After secondary iron overload was excluded as the cause of persistently elevated transferrin saturation and serum ferritin levels, liver biopsy was performed and siderosis was estimated semiquantitatively and quantitatively. A hepatic iron index greater than 1.9 was considered diagnostic for hemochromatosis. Results: Hemochromatosis was diagnosed in 12 patients with type 2 diabetes (prevalence, 1.34% [95% CI, 0.7% to 2.3%]) and 1 control (prevalence, 0.2% [CI, 0.1% to 1.4%]; P = 0.032). The odds ratio of hemochromatosis in association with diabetes was 6.3 (CI, 1.1 to 37.7). Measurement of transferrin saturation was the most sensitive test for hemochromatosis. Conclusions: Genetic hemochromatosis is frequently not diagnosed in patients with diabetes, although it is a hallmark of the disease. Screening for hemochromatosis could be beneficial for patients with diabetes.
AN UNVARNISHED TRUTH
Authors: Stephen J. Weiss, David Ginsburg, John Lowe
Journal: Journal of Clinical Investigation (1999)

Every 5 years, the Editorial Board of the JCI changes hands.To some degree, so does the JCI's philosophical bent.We have just passed the midway point in our term.As such, we look back with some degree of pride at developments ranging from the move to self-publication and a new journal format to our continued ability to provide free access to the Journal's content on the Internet.However, significant as these changes may be, they impact little on the scientific content of the JCI.Now, with over 10,000 decisions having passed through our hands, we have steadily begun to find, and exercise, our own editorial "voice."Since the start of this year, the entire Board of 14 Editors here at the University of Michigan has steadily increased the stringency of the selection process in an effort to improve the quality of the Journal's content.While we have always prized novelty and scientific rigor, we are focusing more attention on identifying those papers with the broadest appeal to our general readership.In Ajit Varki's inaugural address as Editor-in-Chief of the JCI in 1992, he emphasized that "excellence and originality are the major criteria for acceptance rather than trends and fashions" (1).Our commitment to this important tradition continues.However, new developments dictate that the JCI can only retain its leadership if we stay true to the original mission of disseminating the best of the biomedical sciences to as broad an audience as possible (2).