New Treatments for Growing Scourge of Brittle Bones
Authors: Jennifer Fisher Wilson
Journal: Annals of Internal Medicine (2004)

Current Clinical Issues20 January 2004New Treatments for Growing Scourge of Brittle BonesJennifer Fisher WilsonJennifer Fisher WilsonSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-2-200401200-00037 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Patients and physicians do not usually view brittle and broken bones as a health concern as important as breast cancer or heart disease, but they should. Osteoporosis, which causes weak bones in adults, is a subtle, dangerous disease. One in 3 women and 1 in 9 men older than 80 years of age will have a hip fracture as a result of osteoporosis, and 15% to 30% will die of complications related to the fracture. For women, the lifetime risk for dying of hip fracture is the same as the risk of dying of breast cancer, and men older than ...References1. Lippuner K, von Overbeck J, Perrelet R, Bosshard H, Jaeger P. Incidence and direct medical costs of hospitalizations due to osteoporotic fractures in Switzerland. Osteoporos Int. 1997;7:414-25. [PMID: 9425498] CrossrefMedlineGoogle Scholar2. U.S. Preventive Services Task Force. Screening for osteoporosis in postmenopausal women: recommendations and rationale. Ann Intern Med. 2002;137:526-8. [PMID: 12230355] LinkGoogle Scholar3. Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, et al . Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med. 2001;344:1434-41. [PMID: 11346808] CrossrefMedlineGoogle Scholar4. Jamal SA, Cummings SR, Hawker GA. Isosorbide mononitrate increases bone formation and decreases bone resorption in postmenopausal women: a randomized trial. Minneapolis, MN: American Society for Bone and Mineral Research Annual Meeting; 22 September 2003. Google Scholar5. Jamal SA, Browner WS, Bauer DC, Cummings SR. Intermittent use of nitrates increases bone mineral density: the study of osteoporotic fractures. J Bone Min Res. 1998;13:1755-9. [PMID: 9797485] CrossrefMedlineGoogle Scholar6. LaCroix AZ, Cauley JA, Pettinger M, Hsia J, Bauer DC, McGowan J, et al . Statin use, clinical fracture, and bone density in postmenopausal women: results from the Women's Health Initiative Observational Study. Ann Intern Med. 2003;139:97-104. [PMID: 12859159] LinkGoogle Scholar7. Reid IR, Brown JP, Burckhardt P, Horowitz Z, Richardson P, Trechsel U, et al . Intravenous zoledronic acid in postmenopausal women with low bone mineral density. N Engl J Med. 2002;346:653-61. [PMID: 11870242] CrossrefMedlineGoogle Scholar8. Moffet A Jr. Emerging data and experience with lasofoxifene: highlights from clinical trials. Research to Clinical Evidence: Defining the Standard for Postmenopausal Women, satellite symposium of International Osteoporosis Foundation–World Congress on Osteoporosis. Lisbon, Portugal, 10 May 2002. Google Scholar9. Horwitz MJ, Tedesco MB, Gundberg C, Garcia-Ocana A, Stewart AF. Short-term, high-dose parathyroid hormone-related protein as a skeletal anabolic agent for the treatment of postmenopausal osteoporosis. J Clin Endocrinol Metab. 2003;88:569-75. [PMID: 12574182] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Disclosures: None disclosed.E-mail:[email protected]org PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoNew Treatments for Brittle Bones Susan Ott Metrics Cited byLow bone density in patients receiving methadone maintenance treatmentNew Treatments for Brittle BonesSusan Ott, MD 20 January 2004Volume 140, Issue 2Page: 153-156KeywordsBoneBone densityBone mineral densityBone resorptionDrugsEstrogensHipNitratesOsteopeniaOsteoporosis ePublished: 20 January 2004 Issue Published: 20 January 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...