An Advance in Treatment of Tuberculosis
Authors: William W. Stead, Asim K. Dutt
Journal: Annals of Internal Medicine (1980)

Editorials1 August 1980An Advance in Treatment of TuberculosisWILLIAM W. STEAD, M.D., ASIM K. DUTT, M.D.WILLIAM W. STEAD, M.D.Search for more papers by this author, ASIM K. DUTT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-2-364 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA quiet revolution has been occurring in the treatment of tuberculosis through use of a combination of drugs that can kill tubercle bacilli. Field trials based on sound theoretical considerations and experimental corroboration (1-3) have been conducted over the past 10 years; these trials have demonstrated a remarkable efficacy of greatly shortened periods of treatment (4, 5). It has even been found that much of the medication can be given as "pulse therapy" twice weekly rather than daily, as has been the usual practice (6, 7). This new short-course therapy has recently been given limited sanction by the Center for...References1. GROSSET J. The sterilizing value of rifampicin and pyrazinamide in experimental short-course chemotherapy. Bull Int Union Tuberc. 1978;53:5-12. MedlineGoogle Scholar2. GROSSET J. Bacteriological basis of short-course chemotherapy for tuberculosis. In: STEAD WW, DUTT AK. Tuberculosis. Philadelphia: W. B. Saunders; 1980;231-42. Google Scholar3. MITCHISONDICKINSON DJ. Bactericidal mechanisms in shortcourse chemotherapy. Bull Int Union Tuberc. 1978;53:254-9. MedlineGoogle Scholar4. FOXMITCHISON WD. Short-course chemotherapy for pulmonary tuberculosis. Am Rev Respir Dis. 1975;111:325-53. MedlineGoogle Scholar5. FOX W. The current status of short-course chemotherapy. Bull Int Union Tuberc. 1978;53:268-80. Google Scholar6. . Controlled trial of intermittent regimens of rifampin plus isoniazid for pulmonary tuberculosis in Singapore: the results up to 30 months. Am Rev Respir Dis. 1977;116:807-20. MedlineGoogle Scholar7. DUTTJONESSTEAD ALW. Short-course chemotherapy for tuberculosis with largely twice-weekly isoniazid-rifampin. Chest. 1979;75:441-7. CrossrefMedlineGoogle Scholar8. . Guidelines for short-course tuberculosis chemotherapy. Am Rev Respir Dis. 1980;121:611-4. and Morbid Mortal Weekly Rep. 1980;29:97-105. MedlineGoogle Scholar9. FOX W. The modern management and therapy for pulmonary tuberculosis. Proc R Soc Med. 1977;70:4-15. MedlineGoogle Scholar10. . Short-course chemotherapy in pulmonary tuberculosis: a controlled trial by the British Thoracic and Tuberculosis Association. Lancet. 1976;2:1102-4. MedlineGoogle Scholar11. BROUETROUSELL GG. Trial 6-9-12: overall methods and results. Rev Fr Mal Respir. 1977;6(suppl 1):5-13. Google Scholar12. STEADGOOD WW. Contribution of a third drug to various twodrug regimens in the treatment of tuberculosis: analysis of 3104 cases treated in Arkansas. Am Rev Respir Dis. 1980;121:463. Abstract. MedlineGoogle Scholar13. GIRLING D. Adverse reactions to rifampicin in antituberculosis regimen. J Antimicrob Chemother. 1977;3:115-32. CrossrefMedlineGoogle Scholar14. STEADDUTT WA, eds. Tuberculosis. Philadelphia: W. B. Saunders Company; 1980. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRifampinTuberculosis Among Elderly Persons: An Outbreak in a Nursing HomeWILLIAM W. STEAD, M.D.Short-Course Chemotherapy for TuberculosisHOWARD A. BUECHNER, M.D.Chemotherapy for TuberculosisLAURENCE S. FARER, M.D.Correction: Editorial on Tuberculosis TherapyWILLIAM W. STEAD, M.D. 1 August 1980Volume 93, Issue 2Page: 364-365KeywordsDrugsHeart rate Issue Published: 1 August 1980 PDF DownloadLoading ...