tbuckley/cabot-search huggingface dataset:
Nifedipine and Ureteral Colic
Authors: MICHEL MCCORMACK
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 April 1986Nifedipine and Ureteral ColicMICHEL MCCORMACK, M.D., PIERRE WILLIOT, M.D., STEVEN LAPOINTE, M.D., GUY DROUIN, M.D.MICHEL MCCORMACK, M.D., PIERRE WILLIOT, M.D., STEVEN LAPOINTE, M.D., GUY DROUIN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-4-590_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A recent case report (1) has suggested that nifedipine might be useful in alleviating the pain associated with ureteral colic. A pilot study was conducted at our institution to test this hypothesis. We did a prospective randomized study in 20 consecutive patients who presented ureteral colic.The patients either received nifedipine or meperdine on the basis of their chart number. Pregnant women, patients aged over 60 years, patients with cardiovascular disease or hypotension, and patients already receiving anticalcic drugs were excluded. Fourteen men and six women were included, and the mean age was 40 years (range, 26...Reference1. CARROL W. Nifedipine and ureteral colic [Letter]. Ann Intern Med. 1985;102:864. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA Systematic Review of Medical Therapy to Facilitate Passage of Ureteral CalculiRole of adjunctive medical therapy with nifedipine and deflazacort after extracorporeal shock wave lithotripsy of ureteral stonesEffectiveness of nifedipine and deflazacort in the management of distal ureter stonesNifedipine and Methylprednisolone in Facilitating Ureteral Stone Passage: A Randomized, Double-Blind, Placebo-Controlled StudySchmerztherapie der akuten NierenkolikIndications for Calcium AntagonistsNifedipine for the relief of renal colic: A double-blind, placebo-controlled clinical trialIndikationen für Calcium-Antagonisten 1 April 1986Volume 104, Issue 4Page: 590-590KeywordsAbdominal painCardiovascular diseasesChartsDrugsHypotensionPilot studiesPregnancyProspective studies Issue Published: 1 April 1986 PDF DownloadLoading ...
Abstract 4505: Development of small molecules to target ezrin as anti-metastatic agents
Authors: Gülay Bulut, Sung-Hyeok Hong, Kevin Chen, Said Rahim, George W. Kosturko, Elspeth M. Beauchamp, Eric Glasgow, Jeffrey A. Toretsky, Chand Khanna, Aykut Uren
Journal: Cancer Research (2011)

Abstract The most common cause for mortality in osteosarcoma (OS) is respiratory failure due to metastasis to lungs. Thus targeting underlying molecular events that lead to metastasis can provide a significant benefit to patients with fatal metastatic disease. Accumulating evidence from experimental animal models and human cases suggests that ezrin is a key factor in the metastasis of OS cells. Ezrin is a multifunctional protein that connects the actin cytoskeleton to extracellular matrix through transmembrane proteins. We screened small molecule libraries for compounds that directly interact with ezrin protein. Two small molecules that directly bind to ezrin with low micromolar affinity were selected based on inhibiting ezrin function in multiple assays. They inhibited ezrin phosphorylation, ezrin-actin interaction, and ezrin mediated motility of OS cells in culture. These compounds were unique in their mechanism of action such that they inhibited in vitro phosphorylation of ezrin by protein kinase C (PKC) by binding to the substrate not by inhibiting the kinase activity of the enzyme. PKC was able to phosphorylate other substrates in the presence of these novel ezrin inhibitors. They also mimicked the ezrin morpholino phenotype and caused a unique developmental defect consistent with reduced cell motility in zebrafish. Following tail vein injection of osteosarcoma cells to mice, both molecules inhibited lung metastasis of ezrin-sensitive cells, but not ezrin-resistant cells. These two molecules demonstrate a novel targeted therapy that directly inhibits ezrin protein as an approach to prevent tumor metastasis in osteosarcoma and other tumors with elevated ezrin in their metastatic subclones. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4505. doi:10.1158/1538-7445.AM2011-4505
The lawyer's brief on ethics
Authors: Daniel K Sokol
Journal: BMJ (2011)

Background:  The appropriate testing strategy for diagnosing pernicious anaemia using gastric parietal cell (GPC) and/or intrinsic factor antibodies (IFA) is controversial. Intrinsic factor antibodies are found in only about 70% of cases. Indirect immunofluorescence screening for gastric parietal cell antibodies is more sensitive, labour intensive, and less specific.  Methods:  The frequency of antibody positivity (IFA and/or GPC) was retrospectively examined in patients tested for both autoantibodies over a three-year period. It was investigated whether B12 levels were related to antibody status. These findings were validated in a prospective study of IFA in 91 GPC negative patients with low B12 levels.  Results:  Of 847 samples identified in the retrospective study, 4 (0.47%) were positive for only intrinsic factor antibodies, 731 (86.3%) positive for GPC alone, and 112 (13.2%) for both. Student t test on log-transformed data showed B12 levels had no bearing on autoantibody status. 91 consecutive patients with low B12 levels were tested for both autoantibodies; all were negative for gastric parietal cell antibodies. Only one sample was positive for intrinsic factor antibody using the porcine intrinsic factor assay, but was negative by a human recombinant intrinsic factor-based ELISA.  Conclusions:  This study provides evidence that testing for gastric parietal cell antibodies is an appropriate screening test for pernicious anaemia, with intrinsic factor antibodies reserved for confirmatory testing or in patients with other autoantibodies that mask the GPC pattern; B12 levels are not related to autoantibody status.
Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice
Authors: Yoko Morioka, Caterina Casari, Nikolett Wohner, Sungyun Cho, Sachiko Kurata, Ayumi Kitano, Olivier D. Christophe, Peter J. Lenting, Renhao Li, Cécile V. Denis, Nicolas Prévost
Journal: Blood (2014)
A Novel Locus for Dilated Cardiomyopathy, Diffuse Myocardial Fibrosis, and Sudden Death on Chromosome 10q25-26
Authors: Patrick T. Ellinor, Sabine Sasse-Klaassen, Susanne Probst, Brenda Gerull, Jordan T. Shin, Andrea Toeppel, Arnd Heuser, Beate Michely, Danita M. Yoerger, Bong-Seok Song, Bernhard Pilz, Gregor Krings, Bruce Coplin, Peter E. Lange, G. William Dec, Hans Christian Hennies, Ludwig Thierfelder, Calum A. MacRae
Journal: Journal of the American College of Cardiology (2006)
Report of Eight Recent Cases of Locally Advanced Primary Pulmonary Artery Sarcomas: Failure of Doxorubicin-Based Chemotherapy
Authors: Nicolas Penel, Sophie Taieb, Luc Ceugnart, Eric Dansin, Dominique Hoguet, Luc Vanseymortier, Eric Lartigau
Journal: Journal of Thoracic Oncology (2008)
NO points to epigenetics in vascular development
Authors: B. Illi, C. Colussi, J. Rosati, F. Spallotta, S. Nanni, A. Farsetti, M. C. Capogrossi, C. Gaetano
Journal: Cardiovascular Research (2011)

Our understanding of epigenetic mechanisms important for embryonic vascular development and cardiovascular differentiation is still in its infancy. Although molecular analyses, including massive genome sequencing and/or in vitro/in vivo targeting of specific gene sets, has led to the identification of multiple factors involved in stemness maintenance or in the early processes of embryonic layers specification, very little is known about the epigenetic commitment to cardiovascular lineages. The object of this review will be to outline the state of the art in this field and trace the perspective therapeutic consequences of studies aimed at elucidating fundamental epigenetic networks. Special attention will be paid to the emerging role of nitric oxide in this field.
Is There a Doctor in the House? . . . Or the Senate?
Authors: Chadd K. Kraus, Thomas A. Suarez
Journal: JAMA (2004)

The legislative and fiscal influences of Congress, as well as the continuing overall growth in health care spending as a portion of the gross domestic product, make congressional representation by physicians important because physicians have unique expertise in the impact of legislation on patient care and medical practice.To describe physician representation in the US Congress between 1960 and 2004 and relate the results to past representation of physicians in Congress.A retrospective observational study of members of the US Congress from all 50 states and all represented territories, who served from January 1960 to April 2004 (including 108th Congress), using data available in public access databases and congressional biographical records.Physician representation in Congress, including occupation before taking office, state/territory of representation, sex, party affiliation, and time served.During the past 44 years, 25 (1.1%) of 2196 members of Congress were physicians. Physicians in Congress were more likely to be members of the Republican Party (60% vs 45.1% of all members, P = .007) and were similar to other members of Congress in mean years of service (9.2 years for physicians vs 12.3 years for all members, P = .09) and in sex distribution (4.0% female physicians vs 6.8% all female members, P = .57). Physicians in Congress represented 17 states, the Virgin Islands, and Puerto Rico.Physician representation in Congress is low and is in stark contrast with physician roles during the first century of the United States. However, the 8 physicians currently serving in Congress may be indicative of a shift toward more direct influence of physicians in national politics.
Benefits of a multidisciplinary approach in the management of recurrent diabetic foot ulceration in Lithuania: a prospective study.
Authors: V Dargis, O Pantelejeva, A Jonushaite, L Vileikyte, A J Boulton
Journal: Diabetes Care (1999)

OBJECTIVE: To assess the ability of a multidisciplinary approach to diabetic foot care to reduce the incidence of recurrent ulceration and amputations compared with standard care in a 2-year prospective study. RESEARCH DESIGN AND METHODS: A total of 145 patients with a past history of neuropathic foot ulcers but no evidence of peripheral vascular disease entered the study. Subjects were screened for their neuropathic and vascular status at baseline, and all received identical foot care education. The intervention group (n = 56) was followed by the multidisciplinary team of physicians, nurses, and podiatrists with regular podiatry and reeducation every 3 months and the provision of specialty footwear as required. The standard treatment group was followed in local clinics on a trimonthly basis and received identical screening and education at baseline. RESULTS: There were no significant differences at baseline in age (intervention 59.2+/-13.4, standard treatment 58.5+/-11.5 years), duration of diabetes (14.0+/-7.1 vs. 15.6+/-7.8 years), or neuropathic status (vibration perception threshold [VPT]: 31.1+/-12.1 vs. 33.9+/-11.3 V, neuropathy disability score [NDS]: 8.1+/-1.4 vs. 7.9+/-1.7). All patients had an ankle brachial pressure index (ABPI) of &amp;gt;0.9 and at least one palpable foot pulse. Significantly fewer recurrent ulcers were seen in the intervention group than in the standard treatment group during the 2-year period (30.4 vs. 58.4%, P &amp;lt; 0.001). CONCLUSIONS: This prospective study has demonstrated the effectiveness of a multidisciplinary approach to diabetic foot care together with the provision of specialty footwear in the long-term management of high-risk patients with a history of neuropathic foot ulcers.
Epidemiologic study to examine amateur boxers' potential risks
Authors: Phil Gunby
Journal: JAMA (1986)

Much of the debate over the American Medical Association's call for a ban on boxing swirls around the professional fighter and his risk of injury or even death, especially from repeated head trauma. But are the thousands of amateur boxers at any less potential risk of central nervous system damage simply because, at least when fighting in the United States, they wear protective headgear in the ring? A just-announced epidemiologic study in seeking the answer. The study is scheduled to last four years. However, depending on the results four years from now, the investigators—most of whom are at Johns Hopkins University in Baltimore—might seek additional funding. (There have been suggestions in the past that central nervous system changes may not become all that apparent in just four years' time.) In announcing the study, the United States of America Amateur Boxing Federation, Inc, characterized it as "an unprecedented move." The federation
460. MGMTP140K Vector Constructs for Efficient In Vivo Enrichment of Genetically Corrected Cells Following Hematopoietic Cell Gene Transfer
Authors: U.R. Sorg, V. Kleff, G. Nagel, B. Opalka, J. Thomale, B. Kaina, T. Moritz
Journal: Molecular Therapy (2006)

MGMTP140K, a mutant of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) resistant to the inhibitor O6-benzylguanine (BG), protects hematopoietic stem cells (HSC) from the toxicity of alkylating agents such as temozolomide (TMZ) and, therefore, allows efficient in vivo enrichment of transduced cells by BG/TMZ therapy. MGMTP140K has been proposed as a selection marker in gene therapy of monogeneic diseases. If used for this purpose, however, MGMTP140K expression in vectors containing internal ribosomal entry sites (IRES) would be from the compromised 3' position, as the 5' position will be required for the therapeutic gene. Thus, we have investigated SFFV/MESV-based vectors with MGMTP140K inserted 5' or 3' of an EMCV-derived IRES with EGFP in the vice-versa position.
A Model for Evaluation of Addiction Treatment Programs.
Authors: E. A. Wolfson
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973A Model for Evaluation of Addiction Treatment Programs.E. A. Wolfson, F.A.C.P., D. B. Louria, M.D., F.A.C.P., R. F. Hickey, Ph.D., A. Sheffet, M.A., M. Lavenhar, Ph.D., S. Einstein, Ph.D.E. A. Wolfson, F.A.C.P.Search for more papers by this author, D. B. Louria, M.D., F.A.C.P.Search for more papers by this author, R. F. Hickey, Ph.D.Search for more papers by this author, A. Sheffet, M.A.Search for more papers by this author, M. Lavenhar, Ph.D.Search for more papers by this author, S. Einstein, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-814_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe New Jersey Medical School serves as a centralized intake and referral and medical-psychiatric backup for narcotic-dependent patients, who are referred to six independent rehabilitation agencies, each offering a different modality of rehabilitation. A computerized system has been developed for monitoring and tracking patient flow (approximately 2000 patients annually) and evaluating the effectiveness of the agencies.The system includes an area-wide confidential narcotic registry. After initial registration, a 56-character psychosocial profile instrument (interview) is completed on each new patient. After completing the intake interviews and in-hospital detoxification when indicated, the addict is referred for rehabilitation, and monthly status reports are... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Newark, New Jersey PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5Page: 814-814KeywordsAddictsComputersComputing systemsDetoxification Issue Published: 1 May 1973 PDF downloadLoading ...
Predicting ovarian malignancy
Authors: I. Biliatis, N. Ratnavelu
Journal: BMJ (2014)

The latest model looks promising as a triage tool for women with ovarian masses

Following the Calman-Hine report in 1995, the United Kingdom decided to establish a centralised healthcare system for the management of all gynaecological and other malignancies.1 This movement introduced tertiary centres in an attempt to improve the survival outcomes of patients with ovarian cancer by providing the best available treatment from specialist oncology surgeons and nurses in a secure multidisciplinary environment. Although no randomised trial has compared the results of this new scheme, many population cohort and retrospective studies have shown that the management of women by such a team, compared with management by general gynaecologists or surgeons, results in better survival outcomes.2 3

However, for such a costly system to work efficiently, referrals of patients from general practitioners and secondary care to the tertiary centres need to be well designed. The key concept in this setting is accuracy. Patients need to be referred as accurately as possible to avoid benign tumours being operated on by specialist surgeons and patients with ovarian cancer being operated on locally.

This is exactly the point where a prediction model …
'It's Over, Debbie' and the Euthanasia Debate
Authors: George D. Lundberg
Journal: JAMA (1988)

The apparent act of mercy killing described in "It's Over, Debbie" in the A PIECE OF MY MIND column in the Jan 8,1988, issue of<i>JAMA</i><sup>1</sup>stimulated substantial reaction from the medical profession, the public, the media, and legal authorities. At press time, we have received more than 150 letters. Eighteen examples are published in this issue,<sup>2</sup>as are two representative commentaries.<sup>3,4</sup>Most of the early letters were from physicians and tallied about 4:1 against the action the physician described and 3:1 againstThe JOURNALfor publishing the essay. Reactions from the public and media were delayed but were extraordinary in volume and duration. <h3>Purpose and Process of Publication</h3> We published "It's Over, Debbie" to provoke responsible debate within the medical profession and by the public about euthanasia in the United States in 1988.<sup>5</sup>We believe that<i>JAMA</i>is the right place for issues in American
916-84 Balloon Angioplasty Evaluated In Vitro by Intracoronary Ultrasound: A Validation with Histology
Authors: Elma J. Gussenhoven, Aad van der Lugt, Salem H.K. The, Wenguang Li, Theo Stijnen, Frans C. van Egmond, Jeroen van Essen, Hero van Urk, Nicolaas Bom
Journal: Journal of the American College of Cardiology (1995)
Effect of Human Donor Cell Source on Differentiation and Function of Cardiac Induced Pluripotent Stem Cells
Authors: Veronica Sanchez-Freire, Andrew S. Lee, Shijun Hu, Oscar J. Abilez, Ping Liang, Feng Lan, Bruno C. Huber, Sang-Ging Ong, Wan Xing Hong, Mei Huang, Joseph C. Wu
Journal: Journal of the American College of Cardiology (2014)
By Intuitions Differently Formed: How Physicians Assess and Respond to Spiritual Issues in the Clinical Encounter
Authors: Farr A. Curlin, Chad J. Roach
Journal: The American Journal of Bioethics (2007)

"By Intuitions Differently Formed: How Physicians Assess and Respond to Spiritual Issues in the Clinical Encounter." The American Journal of Bioethics, 7(7), pp. 19–20
Risk of Ovarian Cancer after Treatment for Infertility
Authors: Alice S. Whittemore
Journal: New England Journal of Medicine (1995)

More and more women are seeking treatment for infertility,1 probably in part because they are postponing childbearing until an age when their ability to conceive is diminished. The number of office visits to U.S. physicians for infertility services rose from 600,000 in 1968 to about 1.6 million in 19842. And more women are using medications that stimulate ovulation; the number of prescriptions for clomiphene dispensed by U.S. pharmacies nearly doubled from 1973 to 19913. In 1988 approximately 2 million women reported previous exposure to fertility drugs4. The increased use of ovulation-stimulating medications has caused concern about their . . .
Failure of transient lower oesophageal sphincter relaxation in response to gastric distension in patients with achalasia: evidence for neural mediation of transient lower oesophageal sphincter relaxations.
Authors: R H Holloway, J B Wyman, J Dent
Journal: Gut (1989)

Transient lower oesophageal sphincter relaxation (LOSR) is the major mechanism underlying gastro-oesophageal reflux. The mediation and control of LOSRs are incompletely understood but evidence suggests a neural inhibitory mechanism. In this study we have evaluated the effect of gastric distension on LOS function in 16 patients with untreated idiopathic achalasia and compared it with that in 10 healthy controls. With the subjects sitting, the stomach was distended with a liquid mixture that generated 750 ml CO2. Oesophageal pH and motility were monitored for 10 minutes before and after distension. In normal controls, gastric distension induced a four-fold increase in the rate of LOSRs and gas reflux episodes (as evidenced by oesophageal common cavities), whereas this response was absent in the achalasia patients. Basal LOS pressure did not change in either group. These findings are consistent with the notion that transient LOSRs induced by gastric distension are neurally mediated, probably by the same inhibitory nerves that govern swallow mediated LOS relaxation.
An 83-Year-Old Woman With Chronic Illness and Strong Religious Beliefs
Authors: Harold G. Koenig
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FDA Approval of Coronary-Artery Brachytherapy
Authors: Wolf Sapirstein, Bram Zuckerman, James Dillard
Journal: New England Journal of Medicine (2001)

Recurrent coronary stenosis occurs in 20 to 30 percent of patients in whom stents have been implanted for the treatment of obstructive lesions; when it occurs within the stent, it is referred to as in-stent restenosis. Not only is such stenosis a challenging problem to treat, but recurrences occur in as many as 60 percent of patients who have been treated for in-stent stenosis. The magnitude of this health problem becomes apparent when one recognizes that stents are reportedly used in as many as three quarters of the approximately 700,000 percutaneous coronary angioplasty procedures performed annually in the United States. . . .