tbuckley/cabot-search huggingface dataset:
Variants of promyelocytic leukaemia: Their relation to myelodysplasia
Authors: Neelam Varma, Sumitra Dash
Journal: American Journal of Hematology (1990)

Their Relation to MyelodysplasiaWe read with interest the report "Morphologic and cytochemical characteristics of acute promyelocytic leukaemia" by Davey et al. [ 11.We have analyzed 61 cases of acute promyelocytic leukaemia (APL) diagnosed between
Fever: Blessing or Curse?
Authors: Gary Schiller
Journal: Annals of Internal Medicine (1994)

Letters15 December 1994Fever: Blessing or Curse?Gary Schiller, MDGary Schiller, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-12-199412150-00037 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest Dr. Mackowiak's article [1]. In his troubling conclusion he implies that fever may have a salutary benefit for the species that overrides the needs of the individual. It is disconcerting when a physician or scientist attributes a teleologic role to either a disease or a biological response. Scientifically, it must be considered fanciful to assume that fever has an evolutionary basis in promoting survival of a “hopelessly infected and potentially contagious individual. …” The author proposes that fever acts as an evolutionary stimulus to promote the survival of a species at the expense ...References1. Mackowiak PA. Fever: blessing or curse? A unifying hypothesis. Ann Intern Med. 1994; 120:1037-40. Google Scholar2. Ploetz A. Die Tüchtigkeit unserer Rasse und der Schutz der Schwachen. Berlin; 1895:116-44. Google Scholar3. Haycraft J. Social Darwinism and Race Betterment. London; 1895:51-7. Google Scholar4. Ploetz A. Sozialpolitik und rassenhygiene. Archiv für Soziale Gesetzgebung und Statistik. 1902;17:393-425. Google Scholar5. Proctor RN. Racial Hygiene: Medicine under the Nazis. London Harvard University Press; 1988. Google Scholar Author, Article, and Disclosure InformationAuthors: Gary Schiller, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedicine and evolution: time for a new paradigm? 15 December 1994Volume 121, Issue 12 Page: 983 Keywords Fevers Genetics Heredity Scientists ePublished: 15 August 2000 Issue Published: 15 December 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Clinical trial of deglycyrrhizinised liquorice in gastric ulcer.
Authors: K D Bardhan, D C Cumberland, R A Dixon, C D Holdsworth
Journal: Gut (1978)

Ninety-six patients with gastric ulcer were randomly allocated to treatment either with deglycyrrhizinised liquorice or placebo. After four weeks no differences were found between the treatment groups in the proportions with complete healing, whether assessed by gastroscopy or radiology, or in the percentage reduction in ulcer area, or in clinical improvement.
Survival with Systemic Sclerosis (Scleroderma)
Authors: Thomas A. Medsger, Alfonse T. Masi, Gerald P. Rodnan, Thomas G. Benedek, Harry Robinson
Journal: Annals of Internal Medicine (1971)

A life-table analysis of survivorship with scleroderma was done, using 223 patients diagnosed in Pittsburgh, Pennsylvania, and 86 patients in Memphis, Tennessee. The demographic and clinical characteristics of the two series were similar, thus allowing for both comparison of the two groups and analysis of the total 309 patients. A follow-up during 1970 was successful in 94% of all patients. No difference in survival was found between the two patient groups, the combined 7-year cumulative survivorship being 35%. Significantly decreased survival was found in older patients of both series after allowance was made for the natural increase of mortality with age. Males had significantly worse survival than females. Negroes had significantly worse survival than whites during the first year of follow-up of all patients. When no internal organ involvement was detected at entry to study, the negro prognosis was significantly worse throughout a 7-year follow-up period. Renal, cardiac, and pulmonary involvement were each independently correlated with decreased survival.
P3-07-41: Sentinel Lymph Node Biopsy Is a Reliable Method for Lymph Node Evaluation in Neoadjuvant Chemotherapy Treated Breast Cancer Patients.
Authors: R Kaplan, Q Qiu, S Monni, A Swistel, S Shin
Journal: Cancer Research (2011)

Abstract Background: Successful sentinel lymph node mapping in breast cancer patients treated with neoadjuvant chemotherapy has been debated by practicing surgeons due to the potential compromise of the lymphatic drainage system after treatment. Furthermore, whether clinicopathologic variables associated with sentinel lymph node positivity in breast cancer patients differ from similar patients who have been treated with neoadjuvant chemotherapy has not been well-studied. Materials and Methods: Breast cancer patients who received neoadjuvant chemotherapy were identified in our files. A similar number of breast cancer patients who did not receive such therapy was also selected as a comparison group. Clinicopathologic parameters such as age, type of surgical procedure, number of sentinel lymph nodes removed and/or positive, number of non-sentinel lymph nodes removed and/or positive, tumor size, histologic type/grade, presence of lymphovascular invasion, biomarker expression (ER,PR, HER-2/neu) and multifocality were recorded for each patient in both cohorts. Statistical analysis was performed for each cohort to identify variable(s) that correlated with sentinel lymph node positivity. Additional analysis was performed by computing the odds ratio of sentinel lymph node positivity after adjusting for selected variables. Results: Ninety-seven and ninety-three patients who were and were not treated with neoadjuvant chemotherapy, respectively, were identified. In all patients, successful sentinel lymph node mapping was achieved. When these cohorts were separately analyzed, tumor size, lymphovascular invasion, and non-sentinel lymph node positivity were associated with sentinel lymph node positivity in the cohort that did not receive neoadjuvant chemotherapy. In the cohort that received therapy, lymphovascular invasion and non-sentinel lymph node positivity were associated with sentinel lymph node positivity. In addition, after adjusting for tumor size, lymphovascular invasion and histologic grade, patients treated with neoadjuvant chemotherapy were more likely to have sentinel lymph node positivity than those who did not have this treatment (odds ratio: 5.4, 95% CI 2.4, 12.1). Conclusions: Successful sentinel lymph node mapping was achieved in all ninety-seven breast cancer patients studied. Regardless of whether neoadjuvant chemotherapy was administered, the presence of lymphovascular invasion and non-sentinel lymph node positivity were found to predict sentinel lymph node positivity. By comparing two cohorts of breast cancer patients differing only in the use of neoadjuvant chemotherapy and adjusting for select variables, those in the treated cohort still remained more likely to have a positive sentinel lymph node. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P3-07-41.
ENERGY SOURCES AND REQUIREMENTS OF THE EXERCISING HORSE
Authors: P. Harris
Journal: Annual Review of Nutrition (1997)

This review outlines the energy sources available to the horse, from its diet and from its body stores, at rest and while exercising. It looks at the current ways of describing the energy potential of diets fed to horses and discusses the relative advantages and disadvantages of the digestible energy and net energy systems. The more empirical net energy system for calculating the energy available for maintenance and work is compared with a more physiological partitioning system. Finally, the energy requirements for maintenance and exercise are discussed, together with how they may be practically determined and achieved through different diets.
Sequential studies on synovial lymphocyte stimulation by rubella antigen, and rubella virus isolation in an adult with persistent arthritis.
Authors: J K Chantler, D M da Roza, M E Bonnie, G D Reid, D K Ford
Journal: Annals of the Rheumatic Diseases (1985)

The response of synovial lymphocytes from a 65-year-old lady with persistent polyarthritis, to rubella antigen and a number of other microbial agents was studied over a period of 11 months by [3H]thymidine incorporation.The results were correlated with the ability to isolate rubella virus from both peripheral blood and synovial fluid during the same period.The patient showed initially a maximal stimulation index to rubella antigen assayed on five occasions over a five-month period.Rubella virus was detected in both peripheral blood and synovial fluid samples on three occasions during this period.Five months later the lymphoproliferative response of her synovial lymphocytes to rubella antigen had dropped to low levels, and virus could no longer be isolated from synovial exudates.At this time the patient's arthritis had become much less active, indicating that a good correlation existed between the presence of rubella virus, local lymphocyte sensitisation, and the inflammatory reaction.In a recent review 1 the involvement of a number of common viruses, including Epstein-Barr virus, Cox- sackie B virus, and rubella virus (RV), in provoking acute polyarthritis was discussed.In particular, rubella virus was mentioned as the virus most frequently associated with joint diseases after both natural infection or immunisation of adults.2-5In addition to this known association of RV with acute transient joint inflammation several recent reports have indicated that RV persistence may accompany chronic synovitis in patients with no recent history of rubella infection.68Moreover, rubella-associated arthritis has been reported on several occasions to progress to a chronic erosive polyarthritis, clinically indistinguishable from rheumatoid arthritis (RA).9 10 These fragments of information provide tantalising evidence that RV may be one of the aetiological agents in classical rheumatoid arthritis.
CHARACTERISTICS AND MANAGEMENT OF COCAINE POSITIVE ACUTE CORONARY SYNDROME PATIENTS: AN ANALYSIS OF ACC-NCDR ACTION REGISTRY®-GWTG™
Authors: Navdeep Gupta, Jeffrey B. Washam, Stavros Mountantonakis, Shuang Li, Matthew T. Roe, James A. de Lemos, Rohit Arora
Journal: Journal of the American College of Cardiology (2011)
Detection of Intravascular Coagulation by a Serial-Dilution Protamine Sulfate Test
Authors: VICTOR GUREWICH
Journal: Annals of Internal Medicine (1971)

A new protamine sulfate test, using serial dilutions of 1% protamine sulfate in tris buffer, is specific for two fibrinogen derivatives that indicate thrombin generation, fibrin monomers, and fibrin degradation products. It is sensitive to low levels of each. It is insensitive to fibrinogen or fibrinogen degradation products and thus readily distinguishes primary from secondary fibrinolysis. The test is not affected by therapeutic levels of heparin. In clinical experience with this test and the staphylococcal clumping test for fibrinogen-fibrin degradation products no false negative reactions have been encountered in disseminated intravascular coagulation or in acute pulmonary thromboembolism. In 85% of patients with acute deep vein thrombosis the protamine sulfate test was positive. Test results in normal subjects and in patients with a variety of conditions are presented here. The protamine sulfate test is a practical, specific, and sensitive blood test for the exclusion of venous thromboembolic disease and disseminated intravascular coagulation.
REGULATION OF VITAMIN C TRANSPORT
Authors: John X. Wilson
Journal: Annual Review of Nutrition (2005)

Ascorbic acid and dehydroascorbic acid (DHAA, oxidized vitamin C) are dietary sources of vitamin C in humans. Both nutrients are absorbed from the lumen of the intestine and renal tubules by, respectively, enterocytes and renal epithelial cells. Subsequently vitamin C circulates in the blood and enters all of the other cells of the body. Concerning flux across the plasma membrane, simple diffusion of ascorbic acid plays only a small or negligible role. More important are specific mechanisms of transport and metabolism that concentrate vitamin C intracellularly to enhance its function as an enzyme cofactor and antioxidant. The known transport mechanisms are facilitated diffusion of DHAA through glucose-sensitive and -insensitive transporters, facilitated diffusion of ascorbate through channels, exocytosis of ascorbate in secretory vesicles, and secondary active transport of ascorbate through the sodium-dependent vitamin C transporters SVCT1 and SVCT2 proteins that are encoded by the genes Slc23a1 and Slc23a2, respectively. Evidence is reviewed indicating that these transport pathways are regulated under physiological conditions and altered by aging and disease.
Cell Delivery: Core–Shell Hydrogel Microcapsules for Improved Islets Encapsulation (Adv. Healthcare Mater. 5/2013)
Authors: Minglin Ma, Alan Chiu, Gaurav Sahay, Joshua C. Doloff, Nimit Dholakia, Raj Thakrar, Joshua Cohen, Arturo Vegas, Delai Chen, Kaitlin M. Bratlie, Tram Dang, Roger L. York, Jennifer Hollister‐Lock, Gordon C. Weir, Daniel G. Anderson
Journal: Advanced Healthcare Materials (2013)

Islets encapsulation is a promising approach for the treatment of Type I diabetes. On page 667, Daniel G. Anderson and co-workers report a novel design of microcapsules with core–shell structures using two-fluid co-axial electro-jetting. Improved encapsulation and diabetes correction is achieved in a single step by simply confining the islets in the core region of the capsules.
HLA mismatching within or outside of cross-reactive groups (CREGs) is associated with similar outcomes after unrelated hematopoietic stem cell transplantation
Authors: Judith A. Wade, Carolyn Katovich Hurley, Steven K. Takemoto, John Thompson, Stella M. Davies, Thomas C. Fuller, Glenn Rodey, Dennis L. Confer, Harriet Noreen, Michael Haagenson, Fangyu Kan, John Klein, Mary Eapen, Stephen Spellman, Craig Kollman
Journal: Blood (2007)
Occupational asthma in a factory making flux-cored solder containing colophony.
Authors: P S Burge, G Edge, R Hawkins, V White, A J Taylor
Journal: Thorax (1981)

The prevalence of work-related wheeze and breathlessness was measured in factory employees manufacturing flux-cored solder. The flux contained colophony which was heated in the production process, exposing the workers to colophony fumes. Measurement of colophony in the breathing zone defined three grades of exposure with median levels of 1.92 mg/m3 (six subjects), 0.02 mg/m3 (14 subjects), and less than 0.01 mg/m3 (68 subjects). All but two workers in the first two groups, and 90% of a random sample of the last group, were studied. Occupational asthma was present in 21% of the higher two exposure groups and 4% of the lowest exposure group. Mean values of FEV1 and FVC fell with increasing exposure. The prevalence of upper and lower respiratory symptoms was only one-third to a half that found in a previous study of shop floor electronics workers, whose work raised the flux to a higher temperature and produced higher concentrations of colophony fume. Total IgM levels were higher in the solder manufacturers than in unexposed controls, and were higher still in the electronics workers. The solder manufacturers were exposed to colophony fumes at 140 degrees C, below the temperature at which the resin acids decompose, supporting the hypothesis that it is the whole resin acids rather than decomposition products which cause occupational asthma. The threshold limit value should be based on the resin acid content of the fume, and not the aldehyde content as at present. The survey suggests that sensitisation will not be prevented unless exposure is kept well below the present threshold limit value.
Clinician led management can fix the NHS
Authors: David Flook
Journal: BMJ (2006)

Senior medical professionals are often branded as opponents of reform ( BMJ 2006;332:914). We are condemned for believing that resources should be concentrated on frontline staff, rather than big IT systems, independent treatment centres, and the services of management consultants. 

I am not an opponent of reform, nor are most medical personnel. I would support many changes, including (despite a personal loathing of computers) better IT systems, but I do not trust our incompetent government to introduce them. I do, however, oppose the cynical, superficial reforms through which politicians have exploited the NHS. The fraudulent claims for these reforms are many and varied. 

We now frequently hear health ministers contemplating the recent modest fall in cancer mortality and, subtly and dishonestly, insinuating that initiatives such as the “two week wait rule” have contributed to this. In fact, fast track referral prioritises the worried well at the expense of the target population. Of the more than 300 such referrals I have received, …
Cation Uptake by Exchange Resin in Vitro and the Colon as a Sodium-Conserving Organ
Authors: HENRY FIELD, LEON SWELL, D. F. FLICK, ROBERT E. DAILEY
Journal: Circulation (1954)

Cation-exchange resins have not fulfilled early expectations. Those in clinical use do not retain much sodium in the feces when dietary sodium is much restricted. Comparison of the sodium and potassium bound by a resin, in equilibrium with presumably normal electrolytes as found in the terminal ileum, with the amounts of those ions in the feces, permits an over-all evaluation of two major factors operating in the gastrointestinal tract. These are a decreased sodium concentration in the terminal ileal contents when sodium intake is restricted and an absorptive power of the colon sufficient to detach sodium from the resin.
The Sickly Stuarts
Authors: Pamela Boxx
Journal: Journal of the Royal Society of Medicine (2004)

Milo Keynes, in his diligent review of Professor Holmes’ book (June 20004 JRSM1), implies that the contents as described by him contradict rather than confirm the premise of the title. History certainly suggests that the royal Stewarts were a tough lot, prolific and often long-lived despite the dangerous, disease-ridden, wartorn times in which they lived, not to mention the unsavoury lifestyle of many of them.

King Robert II of Scotland, grandson of the Bruce, was the first monarch to hold the hereditary title of Steward. The bloodline ran unbroken from him through his son and then five descendants, all called James Stewart, and all fathering many children, in or out of royal wedlock. However the last of these, James V of Scotland died very shortly after the birth of his daughter Mary. So Mary Queen of Scots had no need in later life to marry her cousin Darnley in order to become a Stewart monarch—she was born one. She also died one, in her mid-forties, having endured imprisonment in a succession of damp and unhygienic castles over two decades until her execution. Sickly? Surely not.

‘The six Stuart monarchs’ described in Professor Holmes’ book succeeded the first eight Stewart monarchs of Scotland as described above. As Milo Keynes reports, they were in turn outlived by the Old and Young Pretenders and the latter’s brother the Cardinal; all three Jacobite Stewarts lived to a ripe old age (for the times) in exile abroad. And Sophia, Electress of Hanover, grand-daughter of James Stewart, VI and I, had initiated the Hanoverian succession which then followed and indeed occupies the British throne to this day.

A bloodline running from 1370 until the present time hardly makes the case for a strain of sickliness. Nor is a consistent pattern of hereditary disease apparent.

Therefore I agree with Milo Keynes’ closing paragraph and was interested to read Graham Brack’s thoughtful letter in the August JRSM.2 As he indicates, Holmes’ spelling of the surname is incorrect; Mary Queen of Scots was brought up in France from babyhood and married the Dauphin as Marie Stuart. The spelling in this country was always Stewart—from King Robert II, the Steward.
Clinical Diagnosis of Dissecting Aneurysm of the Aorta
Authors: O. D. Beresford
Journal: BMJ (1951)

An ante-mortem diagnosis of dissecting aneurysm of the aorta was rarely made before the publication of Shennan's excellent monograph in 1934.Although described as long ago as 1728 by Nicholls, established as a pathological entity by Peacock in 1843, and cor- rectly diagnosed during life by Swaine and Lathan (1856), the correct ante-mortem diagnosis had been recorded only seven times prior to 1934.By 1939 Rogers was able to collect from the literature 24 cases in which the diagnosis had been made during life, and
Medical Notes from the Imperial Yeomanry Hospital at Pretoria
Authors: J. W. Washbourn
Journal: BMJ (1901)

DURING the last few months a number of interesting medical cases have been admitted into the Imperial Yeomanry Hospital at Pretoria, of which a short account appears to be worth recording.EPIDEMIC JAUNDICE.A very large number of cases of jaundice occurred in Pretoria during January and February, and I am informed that similar cases are prevalent in the Orange River Colony.
Blood on My Hands
Authors: Adam Possner
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Israel brings psychiatric care in from cold
Authors: J. Siegelitzovich
Journal: BMJ (1995)

Psychiatric disorders are now being treated in Israel like all physical diseases. Since 1 July people who need treatment may go to the community mental health clinic, psychiatric hospital, or psychiatric department in a hospital of their choice. Their health funds pay for all care, except a 10 shekel (nearly pounds sterling2) fee per outpatient visit in some cases.

Six months after the national health insurance system was …
An Intricate Interplay
Authors: Richard H. Moseley, Beth Manoogian, Thomas Shehab, Sanjay Saint
Journal: New England Journal of Medicine (2012)

A 55-year-old man presented with sinus congestion, headaches, chills, mild nausea, fatigue, and a “foggy” sensation that had lasted approximately 1 week. He reported darker urine than usual and had noticed that his eyes were turning yellow.