Acute Adrenal Insufficiency and the Antiphospholipid Syndrome
Authors: Neil Alperin
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 December 1989Acute Adrenal Insufficiency and the Antiphospholipid SyndromeNeil Alperin, MD, Sateesh Babu, MD, Arthur Weinstein, MDNeil Alperin, MD, Sateesh Babu, MD, Arthur Weinstein, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-11-950 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: A few cases (1, 2) of massive adrenal hemorrhage associated with the lupus anticoagulant have been reported. We report a patient who had an arterial thrombosis and subsequent acute adrenal insufficiency due to bilateral adrenal hemorrhagic thrombosis with laboratory evidence of the antiphospholipid syndrome.A 46-year-old man presented with a 1-day history of severe pain and coldness of the right leg. Angiography revealed an occluded popliteal artery. Therapy with heparin and urokinase was unsuccessful as was subsequent embolectomy, and he eventually had an above-knee amputation. The postoperative period was complicated by thrombocytopenia (platelet count, 45 000 to...References1. Rao R, Vagnucci A, and Amico J. Bilateral massive adrenal hemorrhage: early recognition and treatment. Ann Intern Med. 1989;110:227-35. LinkGoogle Scholar2. Yap A, Powell E, and Yelland C. Lupus anticoagulant. Ann Intern Med. 1989;111:262-3. LinkGoogle Scholar3. Asherson R, Khamashta M, and Gil A. Cerebrovascular disease and antiphospholipid antibodies in systemic lupus erythematosus, lupus-like disease, and the primary antiphospholipid syndrome. Am J Med. 1989;86:391-9. CrossrefMedlineGoogle Scholar4. Alarcon-Segovia D and Sanchez-Guerrero J. Primary antiphospholipid syndrome. J Rheumatol. 1989;16:482-8. MedlineGoogle Scholar5. Asherson R and Hughes G. Recurrent deep vein thrombosis and Addison's disease in "primary" antiphospholipid syndrome. J Rheumatol. 1989;16:378-80. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Neil Alperin, MD; Sateesh Babu, MD; Arthur Weinstein, MDAffiliations: New York Medical College Westchester Medical Center Valhalla, NY 10595 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBilateral Adrenal Haemorrhage and Evans Syndrome as the Initial Presentation of Antiphospholipid Syndrome From Systemic Lupus ErythematosusHématome surrénalien unilatéral inaugural d'un syndrome des antiphospholipidesAdrenal Involvement in the Antiphospholipid SyndromePrimary Antiphospholipid Syndrome Associated with Acute Adrenal FailureVascular Pathology of the Antiphospholipid Antibody SyndromeAdrenal insufficiency as the first clinical manifestation of the primary antiphospholipid antibody syndromeCancer bronchique, syndrome des antiphospholipides et pathologie de la coagulationManagement of Deep Vein Thrombosis and Pulmonary EmbolismAdrenal insufficiency in the antiphospholipidantibody syndromeClinicopathologic correlations of theantiphospholipid syndromeBilateral massive adrenal hemorrhageDetection of antiphospholipid antibodies by immunostaining on thin layer chromatography platesAntiphospholipid antibodies: Lupus anticoagulant and anticardiolipin antibodyThe antiphospholipid syndrome: a syndrome in evolution.IgA antiphospholipid and adrenal insufficiency: Is there a link?Addison's disease, hypertension, renal and hepatic microthrombosis in 'primary' antiphospholipid syndromeAntiphospholipid antibodies and adrenal hemorrhageAntiphospholipid antibody syndrome: Immunologic and clinical aspects 1 December 1989Volume 111, Issue 11Page: 950-951KeywordsAngiographyAnticoagulantsAntiphospholipid syndromeArteriesEmbolectomyHemorrhageHeparinPlateletsResearch laboratoriesThrombosis ePublished: 1 December 2008 Issue Published: 1 December 1989 PDF downloadLoading ...