tbuckley/cabot-search huggingface dataset:
The Great Seal
Authors: Robert W. Buck
Journal: New England Journal of Medicine (1963)

FOR more than a hundred and seventy-five years (since 1783) the Secretary of the Massachusetts Medical Society has had custody of a silver seal mounted in a hardwood handle (Fig. 1). It was long used to impress the signature of the Society upon a disk of red sealing wax covered with a thin paper wafer, which was affixed to official documents. This kind of seal was eventually supplanted by the hand-lever type that embosses the design directly into a sheet of paper without the use of wax.The old seal was without doubt engraved by one of the 15 to . . .
Abstract 2195: Smurf2 is a novel tumor suppressor gene that governs chromatin structure and genome integrity through RNF20
Authors: Michael Blank, Ying E. Zhang
Journal: Cancer Research (2012)

Abstract Cancers are known to harbour alterations in chromatin landscape in addition to allelic mutations. Here, we show that genomic ablation of Smurf2, a HECT-domain E3 ubiquitin ligase, results in dysregulation of global gene expression, altered DNA damage response, and unstable genomes, which culminate to increased susceptibility to various types of cancers in aged mice. We demonstrate that Smurf2 regulates histone H2B monoubiquitination as well as histone H3 tri-methylation at K4 and K79 by targeting RNF20, the major E3 ligase for histone H2B ubiquitination, to proteasomal degradation. We further show that Smurf2 and RNF20 are co-localized at the γ-H2AX foci of double-stranded DNA breaks in the nucleus, and Smurf2 regulates RNF20 stability in human cancer cells. Thus, our data indicate that Smurf2 has a tumor suppression function that normally maintains genomic stability by controlling the epigenetic landscape of histone modifications through RNF20. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2195. doi:1538-7445.AM2012-2195
Laboratory features of pleural effusions.
Authors: P Sutton, S W Clarke
Journal: BMJ (1980)

<h3>Introduction</h3> Patients with bladder cancer (BC) have been found to have worse experiences than those with other cancers which may partly be due to impact on quality of life. Currently, little is known about the impact of physical activity (PA) on BC outcomes. This scoping review aims to identify what interventions are available, their reported efficacy and feasibility, and a description of potential underlying biological mechanisms for their effects. <h3>Methods and analysis</h3> Preferred Reporting Items for Systematic Reviews and Meta-Analyses Scoping Review (ScR) guidelines and the Levac methodology framework will be followed/used. Electronic databases will be searched (MEDLINE, EMBASE, the Cochrane Library, PsycInfo and Health, OpenGray). Two independent reviewers will screen all abstracts and titles and during a second stage and full-text publications for inclusion. All studies describing PA (as an existing lifestyle or as part of an intervention programme) during BC management will be included. Study characteristics will be recorded; qualitative data will be extracted and evaluated using the Donabedian framework. Quantitative data will be extracted and summarised. A further consultation step will be carried out with patients, their family members and healthcare professionals. <h3>Ethics and dissemination</h3> Results will be disseminated through a peer-reviewed publication. Through the consultation step, we will ensure that findings will reach a wide audience and recommendations can be made for future development of PA interventions for patients with BC. Data used will be from publicly available secondary sources, and the consultation step will be carried out as part of patient and public involvement so this study does not require ethical review.
Pyoderma gangrenosum and subcorneal pustular dermatosis, without monoclonal gammopathy
Authors: L. Scerri, I. Zaki, B.R. Allen
Journal: British Journal of Dermatology (1994)

Journal Article Pyoderma gangrenosum and subcorneal pustular dermatosis, without monoclonal gammopathy Get access L. Scerri, L. Scerri Department of Dermatology, University Hospital Queen's Medical Centre, Nottingham NG7 2VH. U.K. Search for other works by this author on: Oxford Academic Google Scholar I. Zaki, I. Zaki Department of Dermatology, University Hospital Queen's Medical Centre, Nottingham NG7 2VH. U.K. Search for other works by this author on: Oxford Academic Google Scholar B.R. Allen B.R. Allen Department of Dermatology, University Hospital Queen's Medical Centre, Nottingham NG7 2VH. U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 130, Issue 3, 1 March 1994, Pages 398–399, https://doi.org/10.1111/j.1365-2133.1994.tb02941.x Published: 01 March 1994
Post‐transfusion purpura: An enigma of alloimmunization
Authors: Peter Lau, Carol M. Sholtis, Richard H. Aster
Journal: American Journal of Hematology (1980)

A patient with post-transfusion purpura is reported. This female patient, sensitized by previous blood transfusion, developed symptomatic thrombocytopenia seven days after a second blood transfusion. A platelet antibody, which had anti-P1A1 specificity, was identified by 51Cr-release assay and by indirect immunofluorescence. Hemorrhage stopped abruptly after plasma exchange therapy. Thrombocytopenia did not recur when the patient was further challenged with P1A1-positive blood and plasma. Anti-P1A1 antibody, detectable by immunofluorescence but not by complement-dependent platelet cytoxicity, persisted in high titer for at least one year after recovery. The heterogeneity and pathogenesis of this clinical syndrome are discussed.
Correction: Apology for "Hypercalcinuria"
Authors: ALVAN R. FEINSTEIN
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 November 1975Correction: Apology for "Hypercalcinuria"ALVAN R. FEINSTEIN, M.D.ALVAN R. FEINSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-5-741_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the August 1975 issue, lines 21 and 22 of column 2 on page 288 should have read: ". . . hypercalcemia" is indicated as preferred in American usage to "hypercalcinuria."To the editor: I suspect that your problems in copy editing are not yet solved. Why in the world wouldhypercalcemiabe "indicated as preferred in American usage to"hypercalcinuria?It is one thing to insert an extra "n" in making neologisms. It is quite another thing to convert urine into blood.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Internal Medicine School of Medicine Yale University New Haven, Connecticut PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1975Volume 83, Issue 5Page: 741-741KeywordsBloodHypercalcemiaUrine Issue Published: 1 November 1975 PDF downloadLoading ...
Tc-99m-MN3 Fab' FRAGMENT OF ANTI-GRANULOCYTE ANTIBODY (LEUKOSCAN®) IN THE DIAGNOSIS OF ATYPICAL ACUTE APPENDICITIS
Authors: B. J. Barron, L. M. Lamki, D. Zelitt, J. H. Duke, K. P. Lally, V. J. Ephron
Journal: Clinical Nuclear Medicine (1996)

Barron, B.; Lamki, L. M.; Zelitt, D.; Duke, J. H.; Lally, K. P.; Ephron, V. J. Author Information
Delayed phenytoin idiosyncrasy.
Authors: S Behrman
Journal: BMJ (1969)

MBITICJOSUNALis the gestation age of the fetus, and not the route by whch termination is effected, as was also shown by Matthews.2There is a national shortage of anti-D immunoglobulin, and while the risk may be small we cannot agree that there is no indi- cation to give immunoglobulin in cases of therapeutic and spontaneous abortion.If rhesus sensitization is to be considered a preventable disease' Rh-negative women having a termination of pregnancy should be afforded protection as soon as sufficient anti-D immunoglobulin is available.This is particularly true in primigravidae, where the postoperative fetal cell count is high and the termination is carried out late in pregnancy.There is no reason to condemn Rh-negative women to affected infants in a later marriage because they had a therapeutic abortion earlier.-We are, etc., E.
HETEROTRANSPLANTATION OF BLOOD VESSELS PRESERVED IN COLD STORAGE
Authors: Alexis Carrel
Journal: The Journal of Experimental Medicine (1907)

The experiments show merely that blood vessels transplanted from dog to cat can act as arteries for seventy-seven days at least; and that having spent several days in cold storage does not interfere with their ordinary functions. The animals operated upon must, however, be kept under observation for several months, or, indeed, for several years, before any conclusion can be drawn concerning the practicability of this method of preservation and heterotransplantation of blood vessels.
Noise exposure and public health.
Authors: W Passchier-Vermeer, W F Passchier
Journal: Environmental Health Perspectives (2000)

Exposure to noise constitutes a health risk. There is sufficient scientific evidence that noise exposure can induce hearing impairment, hypertension and ischemic heart disease, annoyance, sleep disturbance, and decreased school performance. For other effects such as changes in the immune system and birth defects, the evidence is limited. Most public health impacts of noise were already identified in the 1960s and noise abatement is less of a scientific but primarily a policy problem. A subject for further research is the elucidation of the mechanisms underlying noise-induced cardiovascular disorders and the relationship of noise with annoyance and nonacoustical factors modifying health outcomes. A high priority study subject is the effects of noise on children, including cognitive effects and their reversibility. Noise exposure is on the increase, especially in the general living environment, both in industrialized nations and in developing world regions. This implies that in the twenty-first century noise exposure will still be a major public health problem.
Book Review Drinking Careers: A twenty-five-year study of three Navajo populations By Stephen J. Kunitz and Jerrold E. Levy, with Tracy Andrews, Chena DuPuy, K. Ruben Gabriel, and Scott Russell. New Haven, Conn., Yale University Press, 1995. $28.50. 0-300-06000-9
Authors: Walter Randolph Adams
Journal: New England Journal of Medicine (1995)
Failure of Aureomycin in Dermatitis Herpetiformis
Authors: B. Phillips
Journal: BMJ (1951)

The water-excretion test (Kepler-Power) was carried out on the 24th post-operative day and gave the following results: largest volume of day urine, 21 ml.; volume of night urine, 72 ml.; urine urea, 3.4 g.% ; urine chlorides, 320 mg./ 100 ml.; plasma sodium chloride, 565 mg./100 ml.; plasma urea, 45 mg./100 ml.; value of i A," 33.The urine contained 285 mg. of uroporphyrin per litre at the time of death.Post-mortem Examination.-Thelungs showed mucopus in the larger bronchi and patches of unresolved pneumonia at both bases.No abnormality was detected macroscopically in any of the other systems.Sections of the lungs showed bronchopneumonia.Sections of the brain and spinal cord showed none of the characteristic features of the disease.Family History.-Themother died, aged 49 years, of a stroke," the father in his seventies with " dropsy."Three brothers and two sisters are well; their urines were examined, and none contained porphyrins.Two cousins on the mother's side died young-one at 23 years, diagnosed as from acute ascending myelitis, the other at 21 years, diagnosed as from anxiety neurosis and pneumonia.
Chronic Traffic-Related Air Pollution and Stress Interact to Predict Biologic and Clinical Outcomes in Asthma
Authors: Edith Chen, Hannah M. C. Schreier, Robert C. Strunk, Michael Brauer
Journal: Environmental Health Perspectives (2008)

Previous research has documented effects of both physical and social environmental exposures on childhood asthma. However, few studies have considered how these two environments might interact to affect asthma.This study aimed to test interactions between chronic exposure to traffic-related air pollution and chronic family stress in predicting biologic and clinical outcomes in children with asthma.Children with asthma (n = 73, 9-18 years of age) were interviewed about life stress, and asthma-relevant inflammatory markers [cytokine production, immunoglobulin E (IgE), eosinophil counts] were measured. Parents reported on children's symptoms. Children completed daily diaries of symptoms and peak expiratory flow rate (PEFR) measures at baseline and 6 months later. Exposure to traffic-related air pollution was assessed using a land use regression model for nitrogen dioxide concentrations.NO(2) by stress interactions were found for interleukin-5 (beta for interaction term = -0.31, p = 0.02), IgE (interaction beta = -0.29, p = 0.02), and eosinophil counts (interaction beta = -0.24, p = 0.04). These interactions showed that higher chronic stress was associated with heightened inflammatory profiles as pollution levels decreased. Longitudinally, NO(2) by stress interactions emerged for daily diary symptoms (interaction beta = -0.28, p = 0.02), parent-reported symptoms (interaction beta = -0.25, p = 0.07), and PEFR (interaction beta = 0.30, p = 0.03). These interactions indicated that higher chronic stress was associated with increases over time in symptoms and decreases over time in PEFR as pollution levels decreased.The physical and social environments interacted in predicting both biologic and clinical outcomes in children with asthma, suggesting that when pollution exposure is more modest, vulnerability to asthma exacerbations may be heightened in children with higher chronic stress.
RS-T Segment Displacement in Induced Coronary Insufficiency as Studied with Esophageal Leads
Authors: LEONARD SCHERLIS, AVERY A. SANDBERG, JOSEPH WENER, ARTHUR M. MASTER, ARTHUR GRISHMAN
Journal: Circulation (1950)

Esophageal electrocardiograms are utilized as a means of studying the left ventricular cavity potentials in induced coronary insufficiency in patients with angina pectoris. Depressions of the RS-T segment recorded in precordial leads after exercise were consistently associated with simultaneously recorded RS-T elevations at the atrial level. These RS-T deviations are interpreted as indicating that in coronary insufficiency there are widespread changes involving the subendocardial aspect of the left ventricle. A circuit is described to enable the recording of better technical esophageal records despite interference due to extraneous low frequency potentials.
Surviving Sepsis — Practice Guidelines, Marketing Campaigns, and Eli Lilly
Authors: Peter Q. Eichacker, Charles Natanson, Robert L. Danner
Journal: New England Journal of Medicine (2006)

Practice guidelines approved by expert panels are intended to standardize care in such a way as to improve health outcomes. In recent years, the developers of such standards have started grouping evidence-based interventions into "bundles," on the theory that inducing physicians to follow multiple recommendations written into a single protocol has a measurable effect on patients' outcomes. As a side effect, bundled performance measures are ready-made for use in pay-for-performance initiatives, which can base reimbursement on compliance with all the components.Unfortunately, the development of such clusters is vulnerable to manipulation for inappropriate — and possibly harmful — ends. Seeing . . .
Diphenylhydantoin in Emotional Disorders
Authors: Samuel Livingston
Journal: JAMA (1968)

<h3>To the Editor:—</h3> I was appalled by a lengthy article (<i>Life Magazine</i>, Sept 29, 1967) entitled "10,000-to-1 Payoff" which describes "miraculous" control of various types of behavioral aberrations with diphenylhydantoin (DPH). Written by a nonmedical person, it relates the opinions and findings of another nonmedical reporter about the effectiveness of diphenylhydantoin in the treatment of behavioral disorders, and the toxicity of this drug. In the<i>Life</i>article, there are many inaccurate statements. A reporter asked his personal physician, "Is it (DPH) a dangerous drug?" The physician is quoted as having replied: "One of the safest.... there are occasional side effects, of course, but they are rare and generally minor and they go away if the medicine is stopped." The reporter comments: "DPH simply makes you feel normal. It does not sedate or tranquilize you. It does not pep you up. We have yet to read or hear of anyone ever
Death through selfishness and failure of imagination
Authors: R. Smith
Journal: BMJ (2001)

In a world afflicted by murder, mayhem, and malnutrition it may seem bizarre to suggest that the worst thing to happen this year is for some words to come out of a man's mouth—but that may turn out to be so. Last week President Bush reneged on a campaign promise to regulate emissions of carbon dioxide from power stations. This is a serious setback in a world that is already failing to respond responsibly to global warming.1 The short term effects of Bush's …
The efficacy of a health-related quality-of-life intervention during 48 weeks of biologic treatment of patients with moderate to severe psoriasis: results of a multicentre randomized controlled trial
Authors: C.A.C. Prinsen, P.I. Spuls, R. Lindeboom, M.A.G. Sprangers, M.A. de Rie, J. de Korte
Journal: British Journal of Dermatology (2015)

Journal Article The efficacy of a health‐related quality‐of‐life intervention during 48 weeks of biologic treatment of patients with moderate to severe psoriasis: results of a multicentre randomized controlled trial Get access C.A.C. Prinsen, C.A.C. Prinsen Department of Dermatology Academic Medical Center University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam the NetherlandsDepartment of Epidemiology and Biostatistics EMGO+ Institute for Health and Care Research VU University Medical Center De Boelelaan 1089a 1081 HV Amsterdam the Netherlands Search for other works by this author on: Oxford Academic Google Scholar P.I. Spuls, P.I. Spuls Department of Dermatology Academic Medical Center University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam the Netherlands Search for other works by this author on: Oxford Academic Google Scholar R. Lindeboom, R. Lindeboom Division of Clinical Methods and Public Health Master Evidence Based Practice Academic Medical Center University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam the Netherlands Search for other works by this author on: Oxford Academic Google Scholar M.A.G. Sprangers, M.A.G. Sprangers Department of Medical Psychology Academic Medical Center University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam the Netherlands Search for other works by this author on: Oxford Academic Google Scholar M.A. de Rie, M.A. de Rie Department of Dermatology Academic Medical Center University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam the NetherlandsDepartment of Dermatology VU University Medical Center De Boelelaan 1117 P.O. Box 7057 1007 MB Amsterdam the Netherlands Search for other works by this author on: Oxford Academic Google Scholar J. de Korte J. de Korte Department of Dermatology Academic Medical Center University of Amsterdam Meibergdreef 9 1105 AZ Amsterdam the Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 173, Issue 4, 1 October 2015, Pages 1091–1094, https://doi.org/10.1111/bjd.13906 Published: 01 October 2015
Neuropeptide content of lungs from asthmatic and nonasthmatic patients.
Authors: C M Lilly, T R Bai, S A Shore, A E Hall, J M Drazen
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Tracheal and lung parenchymal SP-LI (substance P-like immunoreactivity) and VIP-LI (vasoactive intestinal peptide-like immunoreactivity) content was measured in HPLC-purified tissue extracts from patients with and without asthma. We detected significantly less SP-LI in tracheal tissue from asthmatic than from nonasthmatic patients, whereas parenchymal SP-LI content was not significantly different between these groups. This finding does not support the concept that asthmatic lungs contain excessive amounts of SP. Indeed, lower SP-LI content of tracheal tissues from asthmatic patients may reflect augmented SP release followed by degradation. We detected greater quantities of VIP-LI in tracheal than in parenchymal tissue in both groups, but did not detect significant differences in VIP-LI content in tracheal or parenchymal tissues from asthmatic and nonasthmatic patients. These findings indicate that asthmatic and nonasthmatic lungs contain similar levels of VIP.
Maintenance Pemetrexed Outpatient Therapy Does Not Affect QOL in Patients with Nonsquamous Non-Small Lung Cancer
Authors: Y. Ishiura, H. Ikeda, Y. Shiba, Y. Tearasaki, W. Fukushima, F. Tanikawa, H. Hayase, C. Obata, N. Hirokami, K. Kasahara
Journal: Annals of Oncology (2013)
NECROBIOSIS LIPOIDICA..
Authors: D. M. HILL, E. L. RHODES, JOANNA SHELDON, A. C. AMES, G. R. HOLLISTER
Journal: British Journal of Dermatology (1966)

Journal Article NECROBIOSIS LIPOIDICA.: Serum Insulin and Prednisone‐Glycosuria Tests in a Non‐Diabetic Group. Get access D. M. HILL, M.A., B.M., M.R.C.P., D. M. HILL, M.A., B.M., M.R.C.P. Lecturer in Medicine, King's College Hospital and Medical School, London, S.E.5 Search for other works by this author on: Oxford Academic Google Scholar E. L. RHODES, M.R.C.P., D.C.H., E. L. RHODES, M.R.C.P., D.C.H. Senior Registrar, Department of Dermatology, King's College Hospital and Medical School, London, S.E.5 Search for other works by this author on: Oxford Academic Google Scholar JOANNA SHELDON, M.R.C.P., JOANNA SHELDON, M.R.C.P. Senior Registrar, Medical Unit, King's College Hospital and Medical School, London, S.E.5 Search for other works by this author on: Oxford Academic Google Scholar A. C. AMES, M.B., B.S., B.Sc, A. C. AMES, M.B., B.S., B.Sc Senior Registrar, Department of Chemical Pathology, King's College Hospital and Medical School, London, S.E.5 Search for other works by this author on: Oxford Academic Google Scholar G. R. HOLLISTER, M.B., B.S. G. R. HOLLISTER, M.B., B.S. Lately House Physician, Diabetic Department, King's College Hospital and Medical School, London, S.E.5 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 78, Issue 6, 1 June 1966, Pages 332–336, https://doi.org/10.1111/j.1365-2133.1966.tb14687.x Published: 01 June 1966
Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease
Authors: Damien R. Ashby, Daniel P. Gale, Mark Busbridge, Kevin G. Murphy, Neill D. Duncan, Tom D. Cairns, David H. Taube, Stephen R. Bloom, Frederick W.K. Tam, Richard S. Chapman, Patrick H. Maxwell, Peter Choi
Journal: Kidney International (2009)