tbuckley/cabot-search huggingface dataset:
Abstract 437: ATM regulates glioma migration via MEK-ERK not AKT.
Authors: Jasmine L. Allen, Allison F. Wagner, Jason M. Beckta, James Watson, Sarah E. Golding, Kristoffer C. Valerie
Journal: Cancer Research (2013)

Abstract Glioblastoma multiforme (GBM) is a lethal brain cancer with a life expectancy of only 12-15 months. Current standard treatment for GBM is surgery and chemoradiation. However, there are many difficulties when it comes to treating this aggressive brain cancer due to the inherent radio- and chemo-resistance. Consequently, there is a critical need for new therapeutic approaches to make radiation/chemotherapy more effective. Ataxia telangiectasia (A-T) patients are extremely sensitive to ionizing radiation. The protein mutated in A-T, ATM (A-T mutated), controls the cells’ response to radiation, referred to as the DNA damage response (DDR). ATM is a master protein kinase that targets many proteins during the DDR including regulators of cell cycle checkpoints, DNA repair, and apoptosis. In addition, without any radiation, ATM might regulate glioma dispersal. Using a highly specific inhibitor of the ATM kinase (ATMi), we recently showed that ATM regulates both the ERK and AKT signaling pathways and controls glioma cell migration and invasion in vitro. To take these studies further we have now used a genetic approach and knocked down ATM in human glioma cells. We have recapitulated our previous finding with an ATMi and shown that ATM knockdown glioma cells have reduced ability to migrate in vitro. In order to determine whether MEK/ERK and/or AKT regulate migration, human glioma cells were exposed to a MEK (PD0325901) or an AKT (MK-2266) inhibitor in a ‘scratch-assay’. We found that only the former compound affected migration in vitro. Hence, we have shown that ATM regulates glioma migration in vitro, perhaps via MEK/ERK. On the other hand, ATM might regulate invasion via AKT. The signaling relationship in vitro between ATM, ERK, and AKT is currently being investigated. Furthermore, ongoing studies will establish whether ERK and AKT signaling affect migration and invasion in vivo. Citation Format: Jasmine L. Allen, Allison F. Wagner, Jason M. Beckta, James Watson, Sarah E. Golding, Kristoffer C. Valerie. ATM regulates glioma migration via MEK-ERK not AKT. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 437. doi:10.1158/1538-7445.AM2013-437 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
IL-13 receptor α2 contributes to development of experimental allergic asthma
Authors: Weiguo Chen, Umasundari Sivaprasad, Aaron M. Gibson, Mark B. Ericksen, Christie M. Cunningham, Stacey A. Bass, Kayla G. Kinker, Fred D. Finkelman, Marsha Wills-Karp, Gurjit K. Khurana Hershey
Journal: Journal of Allergy and Clinical Immunology (2013)
Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
Authors: Alessandra Insinga, Silvia Monestiroli, Simona Ronzoni, Vania Gelmetti, Francesco Marchesi, Andrea Viale, Lucia Altucci, Clara Nervi, Saverio Minucci, Pier Giuseppe Pelicci
Journal: Nature Medicine (2004)
Effects of single and combined chemotherapeutic agents on hemopoietic stem cells in mice
Authors: V. K. Jenkins, J. J. Costanzi, H. N. Ellis
Journal: American Journal of Hematology (1976)

Bone marrow cell responses to injections of nitrogen mustard, oncovin, procarbazine, hydrocortisone, and a regimen of all four drugs (MOPH) were evaluated in CRF1 and C57B1/6 mice by determining bone marrow cellularity and content of transplantable colony forming units (CFU) after treatment. The study was done to determine whether the combined regimen, which is widely used clinically in treatment of disseminated Hodgkin's disease, is more or less detrimental to the hemopoietic system than the same drugs used as single agents. Nitrogen mustard and procarbazine used clinically as single drugs are given in three and two times, respectively, greater doses than in the combined regimen. Hydrocortisone, given singly, was least toxic of the drugs, reducing the CFU/femur to 63% and 71% of control values. MOPH appeared slightly more toxic than hydrocortisone, resulting in 41% and 52% of the CFU/femur surviving, and was about equally as toxic as oncovin alone. Nitrogen mustard and procarbazine, administered as single drugs in high doses, were highly suppressive, resulting in only 10-19% survival of CFU/femur, whereas, reduced doses of the two drugs as used in the MOPH regimen spared 30-45% of the CFU/femur. Survival of CFU after MOPH treatment was three to four times greater than after high doses of nitrogen mustard or procarbazine alone. The component drugs of the combined regimen did not act on separate populations of stem cells to produce an additive effect but appeared to inactivate the same population of cells.
THERAPY OF OBSESSIONAL STATES
Authors: LEON SALZMAN
Journal: American Journal of Psychiatry (1966)

The goals and the treatment plan for the obsessional states have been outlined as follows: 1) To discover and elucidate the basis for the excessive feelings of insecurity which require absolute guarantees before action is pursued. 2) To demonstrate by repeated interpretation and encouragement to action that such guarantees are not necessary, but rather that they interfere with living. This requires active assistance in stimulating new adventures for the patient. 3) That the foregoing is possible only when the patient can acknowledge that anxiety is universal and omnipresent and cannot be permanently eliminated from life. This means abandoning the attempts at perfection and superman performance and accepting one's humanness with its limitations. It does not mean being mediocre, average or without ambition but rather it allows the individual to utilize all his assets and potentialities. This is achieved through the trust and intimacy that grows out of a relationship in which one is sincerely trying to be useful to another human being. However, this also requires skill and intelligence, and the treatment must follow techniques that differ radically from the classical psychoanalytic model. We must avoid strengthening the patient's obsessional tendencies and tailor our technique to counter these devices and provide a learning experience which may enable him to alter his defensive patterns. An open, flexible technique with no rigid rules of procedure is demanded, as well as a therapist who is free to experiment and try any number of modifications in the therapeutic process.
Interleukin 8 and Anti-Chlamydia trachomatis Mucosal IgA as Urogenital Immunologic Markers in Patients with C. trachomatis Prostatic Infection
Authors: Sandra Mazzoli, Tommaso Cai, Valentina Rupealta, Andrea Gavazzi, Roberto Castricchi Pagliai, Nicola Mondaini, Riccardo Bartoletti
Journal: European Urology (2006)
Effect of RNA Silencing of Polo-Like Kinase-1 (PLK1) on Apoptosis and Spindle Formation in Human Cancer Cells
Authors: B. Spankuch-Schmitt, J. Bereiter-Hahn, M. Kaufmann, K. Strebhardt
Journal: JNCI Journal of the National Cancer Institute (2002)

Expression of polo-like kinase-1 (PLK1), which has several functions in mitotic progression, is elevated in a broad range of human tumors. To investigate the role of PLK1 in neoplastic proliferation, we used the technique of RNA interference.Cells from several different cancer cell lines (MCF-7 breast cancer cells, HeLa S3 cervical cancer cells, SW-480 colon cancer cells, and A549 lung cancer cells) were transfected with small interfering (si) RNAs targeted against the human PLK1 or lamin genes. Northern and western blot analyses were used to examine PLK1 gene expression in transfected cancer cells and normal cells (human mammary epithelial cells [HMECs]). The phenotype, proliferation, and cell cycle distribution of cells transfected with siRNAs were also monitored by fluorescence microscopy and fluorescence-activated cell sorting analysis.All cancer cell lines transfected with low doses of siRNAs targeted to PLK1 had greatly decreased levels of PLK1 mRNA and protein. siRNA4, which had the strongest inhibitory effect, reduced PLK1 mRNA in MCF-7 cells by 70% and PLK1 protein in MCF-7 cells by 95% 24 hours after transfection. Cell proliferation was reduced by between 66% and 99% 48 hours after transfection, and apoptosis was increased from 1%-5% to 13%-50% in transfected cells. Transfected SW-480 cells were mitotically arrested, and their centrosomes had lost the ability to nucleate microtubules. HMECs took up siRNAs less efficiently than cancer cells, and transfection with siRNAs targeted to PLK1 did not inhibit their proliferation.PLK1 function appears to be essential for centrosome-mediated microtubule events and, consequently, for spindle assembly. siRNAs targeted against human PLK1 may be valuable tools as antiproliferative agents that display activity against a broad spectrum of neoplastic cells at very low doses.
BMA raises concerns about NHS restructuring Professional staff should be involved in health authorities' work Medical students fight increase in course fees Number of total fundholding projects will double
Authors: L. Beecham
Journal: BMJ (1995)

# BMA raises concerns about NHS restructuring {#article-title-2}

The BMA has written, setting out its worries, to the members of the House of Commons committee which is considering the Health Authorities Bill to change the structure and functions of the NHS.

One of the proposals is to replace existing regional health authorities with regional outposts staffed by civil servants. In his letter the chairman of the BMA council, Dr Sandy Macara, says, “We have always opposed the removal of this tier of the NHS as a destruction of strategic and democratic planning in the health service. The reorganisation of regional public health planning as well as the likely duplication of bureaucracy in every district health authority and trust at local level have worrying implications.” The BMA is urging the committee to retain a democratically accountable structure on a regional basis.

The BMA is worried that the proposal to abolish statutory professional advisory committees will lead to a loss of the informed, independent voice of the professions on issues such as education, training, and research.

Dr Macara also draws attention to the possibility that senior public health doctors will be transferred from the NHS to the civil service. This, he says, will inevitably reduce their independent position as advocates for the health of the population as a whole on issues such as tobacco and infection control.

“When stability is so sorely needed in the NHS,” said the chairman to the committee, “we hope that MPs will avoid the temptation of a wholesale restructuring of the NHS at a time when concentrating on patient care must continue to be the number one priority.”

When regional health authorities are abolished new arrangements …
EFFECT OF UPSTREAM CLOPIDOGREL TREATMENT ON INFARCT SIZE AND MICROVASCULAR OBSTRUCTION ASSESSED BY CMR IN PATIENTS WITH STEMI UNDERGOING PRIMARY PCI
Authors: Suzanne de Waha, Ingo Eitel, Steffen Desch, Georg Fuernau, Philipp Lurz, Gerhard Schuler, Holger Thiele
Journal: Journal of the American College of Cardiology (2012)
Problems of the Circulation
Authors: R. J. S. McDowall
Journal: BMJ (1941)

The honour of presenting these lectures, which have been given by many of the most distinguished names in medi- cine, carries with it great responsibilities, but I have at least simplified the task of choosing a subject by taking one akin to that of Oliver himself, who endowed and gave the first Sharpey l'ecture.In these material days a word regardinig the founder may not be out of place, for George Oliver set an example by showing how the practising physician may with great advantage occupy his leisure and contribute to the advance of knowledge.Although a practitioner in Harrogate, he found time to make a most remarkable number of original observations, many of which are little known.His most notable discovery was that of the action of adrenal extracts.This he achieved
Prevertebral ganglia and intestinofugal afferent neurones
Authors: J H Szurszewski, L G Ermilov, S M Miller
Journal: Gut (2002)

Intestinofugal afferent neurones (IFANs) are a unique subset of myenteric ganglion neurones that regulate normal gastrointestinal function. The IFANs relaying mechanosensory information to sympathetic neurones of the prevertebral ganglion (PVG) function as volume detectors. It is possible that mechanosensory information arriving in the PVG via axon collaterals of visceral spinal afferent nerves can be modulated entirely within the PVG itself.
Pediatric Pain Management and Opioids
Authors: Neil L. Schechter
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Estomih Elikanenyi Shoo
Authors: J. Freeman
Journal: BMJ (2010)

Estomih Elikanenyi Shoo (“Esto”) was born in a rural village on the slopes of Mount Kilimanjaro in Tanzania. After early education in local schools, he studied medicine at Makerere University in Kampala, Uganda, under very difficult circumstances: he had to work as a labourer in a local diamond mine to fund his …
Thallium-201 myocardial imaging before and after coronary revascularization: assessment of regional myocardial blood flow and graft patency.
Authors: J L Ritchie, K A Narahara, G B Trobaugh, D L Williams, G W Hamilton
Journal: Circulation (1977)

Twenty patients underwent myocardial imaging with Thallium-201 (201Tl) before and subsequent to coronary artery bypass grafting. All patients had rest and maximal treadmill exercise imaging postoperatively. Eleven of the 20 patients had rest and exercise 201Tl images preoperatively; 9/20 only had rest imaging preoperatively. Postoperative regional exercise perfusion was improved in seven of the 11 patients who had preoperative exercise images, and was associated with regional graft patency in each case. Thirteen of 20 patients showed no new defect with postoperative exercise imaging. The remaining seven patients developed or had an increased defect with exercise. The patients with no new perfusion defects during postoperative study has 26/30 grafts patent (87%). Patients developing a new perfusion defect with exercise had fewer grafts patent (7 of 13 [54%]; P less than 0.03). In these seven cases, a new exercise-induced defect was associated with regional graft closure or residual nonoperated disease. Knowledge of the preoperative coronary anatomy allowed the distinction between ungrafted areas and regional graft dysfunction. We conclude that preoperative and postoperative 201Tl imaging may noninvasively predict graft closure and/or improved regional perfusion with patent grafts.
Absent or Faint Renal Uptake on Bone Scan
Authors: SANG EUN KIM, DEOG YOON KIM, DONG SOO LEE, JUNE-KEY CHUNG, MYUNG CHUL LEE, CHANG-SOON KOH
Journal: Clinical Nuclear Medicine (1991)

A review of 14,296 unselected bone scans identified 889 scans showing absent or faint renal uptake. The majority of cases were associated with renal insufficiency (816/889; 91.8%), while widespread metastatic bone disease was the most common cause in a group of patients without renal disease (53/889; 6.0%). Of the 140 patients with prostate cancer, 108 (77.1%) had evidence of bone metastasis, 19 of whom (17.6%) revealed absent or faint renal uptake, demonstrating that poor renal uptake is more frequently associated with prostate cancer than with any other malignancy. Of note was that 162 out of 328 (49.4%) patients with stomach cancer at varying stages showed evidence of bone metastasis, and 14 of them (8.6%) showed poor renal images on bone scan. Interestingly, ankylosing spondylitis and rheumatoid arthritis were occasional causes of lack of renal activity (4 and 3 cases, respectively). A case of adult-form osteopetrosis, showing strikingly increased uptake mainly in the long bones with markedly diminished renal uptake, was also included in this study. Of the 53 bone scans with metastatic disease showing poor renal uptake, 44 (83.0%) revealed evidence of diffuse or multiple metastases in both spine and ribs, while 49 (92.5%) showed malignant involvement in three or more regions and 35 (66.0%) in four or more regions, suggesting widespread bone involvement in most cases.
Cardiomyoplasty Adds Muscle to Efforts to Alleviate End-Stage Heart Failure
Authors: Chris Raymond
Journal: JAMA (1989)

AN INNOVATIVE PROCEDURE is muscling its way into the cardiac surgeon's repertoire. Known as<i>cardiomyoplasty</i>, it involves fashioning the patient's own back muscle into a wrap that embraces the heart. Surgeons here and abroad are reporting encouraging early results, holding out hope for the thousands of persons with end-stage heart failure who cannot withstand the rigors of bypass surgery or a transplant. Meanwhile, a more complex procedure—using skeletal muscle pouches to augment, ventricular function—appears to be back on track after initial promise turned to disappointment (<i>JAMA</i>1986; 255:1977-1979, 1987;257:2001). Investigators predict this approach eventually will prove successful, but are still working out the ideal configuration. <h3>European Origins</h3> Cardiomyoplasty was introduced in Europe in the mid-1980s. Surgeons remove a rib, free one of the latissimus dorsi muscles from connective tendons, snake it through the rib cage, and wrap it over the heart, preserving the thoracodorsal nerve and major blood vessel. A
Use of Strip Biopsy in a Case of Early Duodenal Cancer
Authors: S. Obata, M. Suenaga, K. Araki, Y. Fujioka, K. Kimura, K. Maeda, K. Miura, J. Mizutani
Journal: Endoscopy (1992)

In a 67-year-old man referred for investigation of an abdominal mass, upper gastrointestinal endoscopy incidentally revealed a polypoid lesion with a central depression in the duodenum. The abdominal mass causing gastric compression was shown by ultrasonography and CT scan to be cyst anterior to the pancreas. Biopsy of the duodenal lesion, however, was suggestive of carcinoma. Strip biopsy was therefore performed. Histological examination showed a tubular adenocarcinoma with invasion limited to the mucosa, and indicated that complete endoscopic resection had been achieved. Follow-up over ten months did not reveal recurrence of the tumor. Strip biopsy would appear to be a safe and efficient method for management of early gastrointestinal tract cancer also in the duodenum.
Response of mouse lung to carbon deposition during injury and repair.
Authors: I Y Adamson, H L Prieditis
Journal: Environmental Health Perspectives (1995)

Increased respiratory disease and daily mortality rates are associated with higher levels of fine particulate air pollutants. We examined the possibility that deposition of even inert particles to previously injured lungs may accentuate pulmonary damage by investigating how the lung handles small carbon particles delivered during acute injury or during fibrotic repair. Mice received 2 mg carbon by intratracheal instillation into lungs already showing acute injury, 3 days after bleomycin (BL), or into lungs with fibrosis, 4 weeks after BL. At 3 days after BL, injury to the type I alveolar epithelium resulted in high protein levels in lavage fluid. Instilling carbon at this time induced a large increase in inflammatory cells, though many particles reached the interstitium, and a high proportion was retained up to 16 weeks later. However, fibrosis in these mice was equal to that found after BL alone. In the mice that received carbon 4 weeks after bleomycin, fibrotic repair had already occurred, and the epithelial surface was restored before particle instillation. After carbon, the subsequent inflammatory reaction cleared most particles, little reached the interstitium, and carbon retained at 16 weeks was not different from that in the carbon-only group. Instilling particles into fibrotic lung did not induce additional fibroblast growth or collagen production. The results indicate that instillation of fine particulates to the alveoli at a time of epithelial injury results in increased translocation to the interstitium. However, deposition of pure carbon into injured lungs does not further stimulate an ongoing fibrotic process, although it alters the patterns of particle deposition and retention in the lung.