Parathyroid Hormone Radioimmunoassays in the Differential Diagnosis of Hypercalcemia Due to Primary Hyperparathyroidism or Malignancy
Authors: EDWARD G. LUFKIN
Journal: Annals of Internal Medicine (1987)

Brief Reports1 April 1987Parathyroid Hormone Radioimmunoassays in the Differential Diagnosis of Hypercalcemia Due to Primary Hyperparathyroidism or MalignancyEDWARD G. LUFKIN, M.D., PAI CHIH KAO, Ph.D., HUNTER HEATH III, M.D.EDWARD G. LUFKIN, M.D.Search for more papers by this author, PAI CHIH KAO, Ph.D.Search for more papers by this author, HUNTER HEATH III, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-4-559 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe determination of serum immunoreactive parathyroid hormone (iPTH) levels remains the most useful laboratory study in the differential diagnosis of hypercalcemia. The iPTH assay has been particularly valuable in distinguishing the two commonest hypercalcemic disorders, primary hyperparathyroidism and malignancy, which together account for more than 80% of cases of persistent hypercalcemia (1-3). The importance of distinguishing these two disorders lies in the great differences in their treatment and prognosis.There are differences in predictive value among commercially available iPTH assays, and some confusion persists concerning the terms used to describe these assays. When Raisz and coworkers (4) submitted aliquots of...References1. FRASERHEALYROSEWATSON PMNL. Discriminant functions in differential diagnosis of hypercalcemia. Lancet. 1971;1:1314-9. CrossrefMedlineGoogle Scholar2. FISKENHEATHBOLD RDA. Hypercalcaemia—a hospital survey. Quart J Med. 1980;49:405-18. MedlineGoogle Scholar3. FISKENHEATHSOMERSBOLD RDSA. Hypercalcaemia in hospital patients: clinical and diagnostic aspects. Lancet. 1981;1:202-7. CrossrefMedlineGoogle Scholar4. RAISZYAJNIKBOCKMANBOWER LCRB. Comparison of commercially available parathyroid hormone immunoassays in the differential diagnosis of hypercalcemia due to hyperparathyroidism or malignancy. Ann Intern Med. 1979;91:739-41. LinkGoogle Scholar5. POTTSSEGREENDRES JGD. Current Clinical Concepts: Assessment of Parathyroid Function with an N-terminal Specific Radioimmunoassay for Intact Parathyroid Hormone. San Juan Capistrano, California: Nichols Institute; 1983. Google Scholar6. KAOJIANGKLEEPURNELL PNGD. Development and validation of a new radioimmunoassay for parathyrin (PTH). Clin Chem. 1982;28:69-74. CrossrefMedlineGoogle Scholar7. ARNAUDTSAOLITTLEDIKE CHJ. Radioimmunoassay of human parathyroid hormone in serum. J Clin Invest. 1971;50:21-34. CrossrefMedlineGoogle Scholar8. HEATHDIBELLA HF. Reduced-volume radioimmunoassay for parathyrin and calcitonin in serum, for use in pediatric and small-animal studies. Clin Chem. 1978;24:1833-5. CrossrefMedlineGoogle Scholar9. CLARKHAWKERMARTINSLATOPOLSKY SCKE. Parathyroid hormone measurement: clinical utility of a radioimmunoassay for the C-terminal and middle region of PTH. Clin Conf 1982;3:1-6. Google Scholar10. MARTINHRUSKAFREITAGBELLORIN-FONTKLAHRSLATOPOLSKY KKJESE. Clinical utility of radioimmunoassays for parathyroid hormone. Miner Electrolyte Metab. 1980;3:283-90. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EDWARD G. LUFKIN, M.D.; PAI CHIH KAO, Ph.D.; HUNTER HEATHIII, M.D.Affiliations: Mayo Clinic Mayo Foundation Rochester, Minnesota PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPTH Assays and Their Clinical SignificanceMetabolism and Measurement of Parathyroid HormoneAcute and chronic regulation of circulating PTH: Significance in health and in diseaseThe Causes of Hypercalcemia in Okinawan Patients: AnInternational ComparisonFifty years of development in the endocrinology laboratoryParathyroid hormone-related protein in metastatic breast cancer induced hypercalcemia: A case reportHen Egg Yolk Antibodies Purified by Antigen Affinity under Highly Alkaline Conditions Provide New Tools for Diagnostics. 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