tbuckley/cabot-search huggingface dataset:
Improvement in global and segmental left ventricular contractility following autologous bone marrow cell transplantation in humans with severe ischemic heart failure
Authors: Emerson C. Perin, Hans F. Dohmann, Radovan Borojevic, Hans J. Dohmann, Antonio C. Carvalho, Yong J. Geng, Andre Luiz, S. Sousa, Guilherme V. Silva, Fernando Rangel, Suzana A. Silva, Isabel Rossi, Roberto Esporcatte, James T. Willerson
Journal: Journal of the American College of Cardiology (2003)
Election Affects Markets
Authors: Mike Mitka
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Management of the antiphospholipid syndrome.
Authors: M A Khamashta, T Wallington
Journal: Annals of the Rheumatic Diseases (1991)

In 1987 Harris et all proposed that the com- bination of clinical features including both venous and arterial occlusive events, recurrent spontaneous abortions, and thrombocytopenia with antiphospholipid antibodies, identified as moderate to high titres of IgG or IgM anti- cardiolipin antibody or the lupus anticoagulant, should be termed the 'antiphospholipid syn- drome'.Lupus anticoagulant, which was described in the 1950s by Conley and Hartman,2 was first associated with thrombotic events by Bowie et al in 1963.3Subsequently, anti- phospholipid antibodies have been recognised to encompass a spectrum ofantibody specificities which has been associated with an expanding range of clinical manifestations (table ). Case reportsThe following cases illustrate some of the major clinical features of the antiphospholipid syndrome and the challenges posed to treat- ment.
Persistent Tissue Kinetics and Redistribution of Nanoparticles, Quantum Dot 705, in Mice: ICP-MS Quantitative Assessment
Authors: Raymond S.H. Yang, Louis W. Chang, Jui-Pin Wu, Ming-Hsien Tsai, Hsiu-Jen Wang, Yu-Chun Kuo, Teng-Kuang Yeh, Chung Shi Yang, Pinpin Lin
Journal: Environmental Health Perspectives (2007)

Quantum dots (QDs) are autofluorescent semiconductor nanocrystals that can be used for in vivo biomedical imaging. However, we know little about their in vivo disposition and health consequences.We assessed the tissue disposition and pharmacokinetics of QD705 in mice.We determined quantitatively the blood and tissue kinetics of QD705 in mice after single intravenous (iv) injection at the dose of 40 pmol for up to 28 days. Inductively coupled plasma-mass spectrometry (ICP-MS) measurement of cadmium was the primary method of quantification of QD705. Fluorescence light microscopy revealed the localization of QD705 in tissues.Plasma half-life of QD705 in mice was short (18.5 hr), but ICP-MS analyses revealed QD705 persisted and even continued to increase in the spleen, liver, and kidney 28 days after an iv dose. Considerable time-dependent redistribution from body mass to liver and kidney was apparent between 1 and 28 days postdosing. The recoveries at both time points were near 100%; all QD705s reside in the body. Neither fecal nor urinary excretion of QD705 was detected appreciably in 28 days postdosing. Fluorescence microscopy demonstrated deposition of QD705 in the liver, spleen, and kidneys.Judging from the continued increase in the liver (29-42% of the administered dose), kidney (1.5-9.2%), and spleen (4.8-5.2%) between 1 and 28 days without any appreciable excretion, QD705 has a very long half-life, potentially weeks or even months, in the body and its health consequences deserve serious consideration.
Abstract 3894: Regulation of VDUP1 expression in breast cancer cells by cyclopamine
Authors: Jeffrey M. Voigt, Arjun Bajaria, Richard E. Dearborn
Journal: Cancer Research (2010)

Abstract VDUP1 (TXNIP) is a tumor suppressor protein that contributes to the regulation of cell proliferation through its role as an inhibitor of thioredoxin (TRX). VDUP1 expression is decreased in a variety of tumor cells relative to non-tumor cells and enforced expression of VDUP1 slows tumor cell growth. 1,25-Dihydroxyvitamin D3 (VD3) has long been known to increase VDUP1 expression in tumor cells, although the full extent of VDUP1 regulation is not known. Preliminary experiments with Drosophila mutants lacking Hedgehog (Hh) secretion suggested that VDUP1 expression could be regulated by the Hh signaling pathway. Experiments were conducted to determine the ability of cyclopamine (CYCLO), an inhibitor of Hh signaling, to regulate VDUP1 expression in breast cancer cells. MDA-231 and MCF-7 cells, grown in RPMI 1640 medium containing 10% fetal calf serum, were treated with CYCLO (5-20 μM) or vehicle (methanol) for 24-72 hrs. Using an anti-VDUP1 antibody, VDUP1 localization was determined by immunofluorescence staining of cells grown on gelatin-coated coverslips following fixation in 4% paraformaldehyde. VDUP1 expression in methanol-treated MDA-231 cells showed a greater expression of VDUP1 in nuclei, indicated by overlapping expression with the nuclear marker histone deacetylase, as compared to cytoplasm. Treatment with 20 μM CYCLO for 72 hours resulted in a decrease in nuclear VDUP1 expression, coupled with a dramatic increase in cytoplasmic VDUP1. This redistribution of VDUP1 from the nucleus to the cytoplasm was detected as early as 24 hours after initiation of treatment with 20 μM CYCLO and was also detected following treatment with 10 μM CYCLO for 72 hours. The CYCLO-induced decrease in nuclear VDUP1 was confirmed with Western blotting. In contrast, no such changes were detected in CYCLO-treated MCF-7 cells. To investigate the direct effect of CYCLO treatment on vdup1 promoter activity, a 1.7 kb fragment of the human vdup1 promoter was inserted upstream of a luciferase gene to generate a vdup1/pLuc plasmid. vdup1/pLuc was co-transfected into CYCLO-treated cells (20 μM), along with a β-galactosidase plasmid and luciferase activity was determined. CYCLO treatment of MDA-231 cells resulted in a significant decrease in luciferase activity, as compared to methanol-treated cells. No changes in luciferase activity were seen following similar experiments conducted with MCF-7 cells. These results demonstrate the novel finding that inhibition of Hh signaling alters both the level of VDUP1 expression and the intracellular distribution of VDUP1 in MDA-231 cells. Future experiments will be directed at determining the mechanisms responsible for the change in the subcellular distribution of VDUP1 seen following CYCLO treatment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3894.
Focally Enhanced F-18 Fluorodeoxyglucose (FDG) Uptake in Incidentally Detected Pulmonary Embolism on PET/CT Scanning
Authors: I Goethals, P Smeets, O De Winter, L Noens
Journal: Clinical Nuclear Medicine (2006)

Abnormal F-18 fluorodeoxyglucose (FDG) accumulation patterns in the lung in patients with cancer having whole-body F-18 FDG-PET/CT scanning for restaging purposes are usually associated with primary lung tumors or lung metastases. Other diagnoses include postobstructive pneumonia and/or atelectasis, granulomatous lung disease, or occult lung infarction. In the latter, enhanced F-18 FDG accumulation topographically matches otherwise proven areas of pulmonary embolism. We document focally enhanced F-18 FDG uptake in the thrombus in the right pulmonary artery in a patient with silent pulmonary embolism. We hypothesize that enhanced F-18 FDG accumulation is attributed to the inflammatory reaction and scavenger cell activity associated with the pathophysiological cascade in pulmonary embolism.
Abstract 3202: Decreased Dkk3 protein expression is associated with a poor prognosis of cervical cancer
Authors: Eun-Ju Lee, Mi Kyung Kim, Hyung Moo Park, Sang-Hoon Lee, Dong-Ho Kim, Moo-Yul Lee, Soon-Chul Myung, Won Yong Kim
Journal: Cancer Research (2011)

Abstract Dkk3 has tumor suppressor properties in various cancers. Recently, we reported that the mRNA level of Dkk3 gene was down-regulated by epigenetic alteration in cervical cancer and that forced expression of Dkk3 resulted in the growth inhibition of cervical cancer cells. The aim of this study was to assess the expression of Dkk3 protein in cervical cancer tissue and determine potential clinical correlations. Immunohistochemical analysis was performed on 94 cervical cancer tissues. Clinical and pathological parameters were obtained from medical record. Survival data were estimated using Kaplan-Meier estimates and compared with log-rank test where indicated. Out of 94 tissue samples, negative, weak, moderate and high expression of Dkk3 were observed in 29 (30.9%), 31 (33.0%), 18 (19.1%) and 16 (17.0%) tissue samples. Dkk3 expression was negatively correlated with FIGO clinical stage (p&amp;lt;0.03, Mann-Whitney test). The 5-year disease free survival of patients with a negative or weak expression was significantly lower than that of those with moderate or high expression (70.6% versus 86.3%, respectively, p=0.04, log-rank test). The result of this study showed that down-regulation of Dkk3 is associated with advanced FIGO clinical stage and poor survival outcome of cervical cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3202. doi:10.1158/1538-7445.AM2011-3202
WHAT IS A MEDICAL EMERGENCY?
Authors: Robert D. Potter
Journal: JAMA (1952)

The advent of the various 24 hour emergency call plans, sponsored by numerous county medical societies throughout the nation, is one of the major advances of public service projects by organized medicine. The plans overcome criticism that a physician is not available for emergency house calls. The swift growth of such emergency call plans has been described by the Council on Medical Service of the American Medical Association.<sup>1</sup> Because of its geographic location on the island of Manhattan of the City of New York, the Medical Society of the County of New York probably handles the greatest volume of emergency medical calls of any county society in the country. In addition to 2,000,000 permanent residents of Manhattan, some 17,000,000 persons visit the city annually as transients. Most of the latter stay in Manhattan hotels. In the calendar year of 1951, more than 4,500 house calls were made by 250
Paler Is Better, Say Skin Cancer Fighters
Authors: Marsha F. Goldsmith
Journal: JAMA (1987)

"THE PORCELAIN LOOK" is not the title of a new spy story or romance novel, but the prescription Sidney Hurwitz, MD, proposes for reversing what dermatologists call an "alarming" increase of skin cancer in this country. The most frightening rise is in the incidence of malignant melanoma, which is greater than that for any other type of carcinoma except lung cancer in women. For a child born in the United States in the 1930s, according to the Skin Cancer Foundation, an organization devoted to promulgating information about the disorders, the lifetime risk of developing skin cancer was 1 in 1500. While for a black child born today the risk is still less than 1 in 1000, it has increased 15-fold for whites, says the foundation—to 1 in 100. Basal cell carcinoma, the most common type of skin cancer, accounts for at least 400 000 cases a year in the United
Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia
Authors: Gerry P Crossan, Louise van der Weyden, Ivan V Rosado, Frederic Langevin, Pierre-Henri L Gaillard, Rebecca E McIntyre, Ferdia Gallagher, Mikko I Kettunen, David Y Lewis, Kevin Brindle, Mark J Arends, David J Adams, Ketan J Patel
Journal: Nature Genetics (2011)
An introduction to housing and health.
Authors: S. Lowry
Journal: BMJ (1989)

The connection between health and the dwellings of the population is one of the most important that exists FLORENCE NIGHTINGALE A recent WHO publication on housing and health mentioned the need to reduce the "cruel toll of death and disease directly attributable to the appalling living conditions of one quarter of the world's population.'"We can all accept that living in shanty towns in the Third World can damage people's health, but many of us have forgotten how much housing can influence health in Britain. Housing and public healthThe Victorians appreciated the association between poor housing and ill health.They explained it in terms of the miasmic theory -bad smells transmitted disease -but their solutions (slum clearance and improved sanitation) did improve health.Improvements in the death rates from infectious diseases like cholera and typhoid and, to some extent, tuberculosis owed more to improved standards ofhousing than to knowledge of microbiology and the development of antibiotics.2The Victorians took a broad view of health.Their attempts to reduce overcrowding in slums were prompted largely by outrage at the potential harm to mental and moral "health" of inadequate separation of the sexes, but the results reduced the spread of infectious illness.Housing had a central role in the development of the public health movement.34In 1918 there was an outcry when it was discovered that 41% ofconscripts were ofmedical grade C3-unfit for military service.There were calls for improved public health, including better housing.After the war houses were in short supply-600 000 too few by the armistice, and over 800000 by 1921-and a huge building programme began.The solid, well constructed semidetached houses with private gardens and indoor bathrooms built in the 1920s and 1930s really were the promised "homes fit for heroes."Indeed, they still compare favourably with many of the houses built since.
MRI FINDINGS IN THE SHOULDER OF COMPLETELY ASYMPTOMATIC ADOLESCENT ELITE TENNIS PLAYERS
Authors: F Johansson, E DeBri, L Swärdh, A Cools, A Adolfsson, G Jenner, E Skillgate
Journal: British Journal of Sports Medicine (2014)

Background Shoulder pathology in adult tennis players including rotator cuff pathology is well known. However, early adaptations have not previously been studied in the adolescent elite tennis players. Objectives To describe magnetic resonance imaging (MRI) findings in the shoulder in asymptomatic elite adolescent tennis players. Design A MRI scan using a 3 Tesla scanner of both shoulders were performed. PD (proton density) weighted images with fat-saturation in oblique coronal, oblique sagittal and axial planes together with oblique sagittal T2 images were reviewed especially for the presence of abnormalities regarding labral lesions and rotator-cuff lesions by two radiologists in consensus. The MRI scans were evaluated by to independent experienced radiologists in a blinded manner according to a pre-defined protocol. Data were collected retrospectively for the dominant arm and contralateral arm respectively. Statistical analyses were performed using SPSS software. Setting Testing environment at Medical Rontgen, Sweden. Participants 35 adolescent elite tennis players from the Swedish national team were selected (ages 13–24 years median age 17). 15 boys and 20 girls participated in the study. Intervention Findings were described according to a predefined protocol. Main outcome measurements MRI findings of the dominant and non-dominant shoulder. Results 19 players (54%) had a normal MRI examination and 16 players (46%) had abnormal findings of which 14 players showed affected tendons/tendinosis. The predominant findings were made in infraspinatus (n=10), Supraspinatus (n=5) and Subscapularis (n=1). Two players had findings in both infra- and supraspinatus. Conclusions This is the first study describing MRI findings in adolescent elite tennis players, revealing infraspinatus and supraspinatus affected tendons/tendinosis in this asymptomatic overhead athletic population. The results can serve as the baseline for a future prospective longitudinal cohort study.
CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo
Authors: Tim Worbs, Thorsten R. Mempel, Jasmin Bölter, Ulrich H. von Andrian, Reinhold Förster
Journal: The Journal of Experimental Medicine (2007)

In contrast to lymphocyte homing, little is known about molecular cues controlling the motility of lymphocytes within lymphoid organs. Applying intravital two-photon microscopy, we demonstrate that chemokine receptor CCR7 signaling enhances the intranodal motility of CD4+ T cells. Compared to wild-type (WT) cells, the average velocity and mean motility coefficient of adoptively transferred CCR7-deficient CD4+ T lymphocytes in T cell areas of WT recipients were reduced by 33 and 55%, respectively. Both parameters were comparably reduced for WT T lymphocytes migrating in T cell areas of plt/plt mice lacking CCR7 ligands. Importantly, systemic application of the CCR7 ligand CCL21 was sufficient to rescue the motility of WT T lymphocytes inside T cell areas of plt/plt recipients. Comparing the movement behavior of T cells in subcapsular areas that are devoid of detectable amounts of CCR7 ligands even in WT mice, we failed to reveal any differences between WT and plt/plt recipients. Furthermore, in both WT and plt/plt recipients, highly motile T cells rapidly accumulated in the subcapsular region after subcutaneous injection of the CCR7 ligand CCL19. Collectively, these data identify CCR7 and its ligands as important chemokinetic factors stimulating the basal motility of CD4+ T cells inside lymph nodes in vivo.
PMO-185 Duodenal tamponade: a case series and fourth modality in gastrointestinal bleed control: Abstract PMO-185 Table 1
Authors: A Gelsthorpe, N Patodi, M Ahmed
Journal: Gut (2012)

<h3>Introduction</h3> The mortalitiy associated with gastrointestinal bleeding is around 10%, a figure which has remained roughly constant despite continuing innovation in therapy. The use of injection, thermocoagulation, and endo-clips is widely practiced in the context of bleeding duodenal ulcers. However a number of patients will re-bleed in spite of dual or even triple therapy. In cases where co-morbidity precludes surgical intervention further therapeutic options may be non-existent. <h3>Methods</h3> We describe a case series of five patients with multiple co-morbidity who presented with upper gastrointestinal haemorrhage from duodenal lesions. A variety of therapeutic modalities were employed that is, injection with Adrenaline, thermocoagulation or endoclips. Unfortunately haemostasis was not achieved and surgical intervention deemed inappropriate. Our technique involves tamponade with a 18 mm CRE (constant radial expansion) balloon inflated in the duodenum. The gastroscope with the deflated balloon is passed via the pylorus. The balloon is then inflated keeping the proximal portion of the balloon under direct vision at all times to ensure correct placement. Tamponade is maintained for up to 50 min. <h3>Results</h3> This procedure achieved haemostasis in all five cases. The tamponade was maintained for a total of between 10 and 50 min. <h3>Conclusion</h3> Duodenal tamponade to control Haemorrhage has been described previously only twice and has required either specialist equipment<sup>1</sup> or surgical intervention.<sup>2</sup> The CRE balloon is readily available within most endoscopy units and therefore no expenditure is required to use this new modality. In addition the technique is easily learnt and can be readily applied to lesions whose orientation makes targeted intervention difficult. Tamponade is a useful adjunct and may prove lifesaving in an otherwise hopeless situation. <h3>Competing interests</h3> None declared. <h3>References</h3> 1. <b>Rohatgi A</b>, Houghton PW. Duodenal tamponade in the treatment of an intractable peptic ulcer bleed. <i>Ann R Coll Surg Engl</i> 2001;<b>83</b>:335–6. 2. <b>Taylor TV</b>. Isolated duodenal tamponade for treatment of bleeding duodenal ulcer. <i>Lancet</i> 1988;<b>1</b>:911–12.
Dynamical learning algorithms for neural networks and neural constructivism
Authors: Enrico Blanzieri
Journal: Behavioral and Brain Sciences (1997)

The present commentary addresses the Quartz &amp; Sejnowski (Q&amp;S) target article from the point of view of the dynamical learning algorithm for neural networks. These techniques implicitly adopt Q&amp;S's neural constructivist paradigm. Their approach hence receives support from the biological and psychological evidence. Limitations of constructive learning for neural networks are discussed with an emphasis on grammar learning.
Virus-induced neurobehavioral disorders: mechanisms and implications
Authors: Keizo Tomonaga
Journal: Trends in Molecular Medicine (2004)

One hypothesis for the etiology of neuropsychiatric disorders proposes that viral infection contributes to the induction of neuronal system dysfunction, resulting in a wide range of behavioral abnormalities. Recent research in molecular biology supports this hypothesis and refocuses on the role of viral infection in the development of psychiatric disorders. Viral infection can induce deleterious effects in the central nervous system by direct and/or indirect pathways. Understanding the mechanisms of glial cell dysfunction caused by persistent viral infection should lead to novel insights into the development of neurobehavioral disorders, including human mental illnesses, and to the possible development of treatments.
ABSORPTION AND ELIMTNATION OF MERCURY IN THE DIFFERENT METHODS USED IN THE TREATMENT OF SYPHILIS.
Authors: SVEND LOMHOLT
Journal: British Journal of Dermatology (1920)

OoE experience tends to prove that the therapeutic result of any particular mercurial treatment depends^ entirely upou the qnantity of mercury absorbed and brought in circulation and upon tlie regularity of this ab,sorption.The chemical character of the mercury compound used is but of slight consequence if only the conipoand can be easily decomposed in the body.Certain aromatic compounds cannot-or can only partially-be decomposed, and conseqnently their therapeutic effect is correspondingly diminished.The rapidity of elimination depends mainly upon the rapidity of aljsorption, and can be studied by quantitative analysis of the excretions of the body, i. e. nrine andfseces.The sweat contains only minute quantities of mercury, and the same is the case with the saliva, which, moreover, is chiefly swallowed.The expired air contains no mercnry.Tlie rapidity of the absorption of intramuscnlarly injected mercnry can also be studied directly on animals by isolating the foci of injection and determining their content of mercnry at different intervals.