tbuckley/cabot-search huggingface dataset:
Migraine, headache, and survival in women.
Authors: W E Waters, M J Campbell, P C Elwood
Journal: BMJ (1983)

A population study of 1310 women aged 45-64 years determined the prevalence of headache and migraine in the preceding year. To investigate the hypothesis that women with migraine had a higher mortality rate, these women were followed up nearly 12 years later. Unexpectedly, the mortality was found to be higher in women without headaches. Women with headaches and migraine had a relative risk of dying of 0.72 (95% confidence interval 0.52-1.00) compared with those without headaches.
Cardiac angiotensin converting enzyme overproduction indicates interstitial activation in renovascular hypertension
Authors: M. Challah, A. Nicoletti, J.F. Arnal, M. Philippe, I. Laboulandine, J. Allegrini, F. Alhenc-Gelas, S. Danilov, J.B. Michel
Journal: Cardiovascular Research (1995)

Journal Article Cardiac angiotensin converting enzyme overproduction indicates interstitial activation in renovascular hypertension Get access M. Challah, M. Challah * aU-367 INSERM, 17, rue du Fer à Moulin, 75005 Paris, France *Corresponding author: Tel. 33.1.43.36.47.35; Fax 33.1.45.35.66.29. Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Nicoletti, A. Nicoletti bU-28 INSERM, Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar J.F. Arnal, J.F. Arnal aU-367 INSERM, 17, rue du Fer à Moulin, 75005 Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Philippe, M. Philippe aU-367 INSERM, 17, rue du Fer à Moulin, 75005 Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar I. Laboulandine, I. Laboulandine aU-367 INSERM, 17, rue du Fer à Moulin, 75005 Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Allegrini, J. Allegrini aU-367 INSERM, 17, rue du Fer à Moulin, 75005 Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar F. Alhenc-Gelas, F. Alhenc-Gelas aU-367 INSERM, 17, rue du Fer à Moulin, 75005 Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Danilov, S. Danilov aU-367 INSERM, 17, rue du Fer à Moulin, 75005 Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar J.B. Michel J.B. Michel aU-367 INSERM, 17, rue du Fer à Moulin, 75005 Paris, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 30, Issue 2, August 1995, Pages 231–239, https://doi.org/10.1016/S0008-6363(96)88516-6 Published: 01 August 1995 Article history Received: 24 January 1995 Accepted: 28 March 1995 Published: 01 August 1995
Malignant Neglect: The Failure to Address the Need to Prevent Premature Non-communicable Disease Morbidity and Mortality
Authors: David Stuckler, Sanjay Basu
Journal: PLoS Medicine (2013)

David Stuckler and Sanjay Basu comment on a study by Carl Lachat and colleagues documenting the lack of policies addressing noncommunicable disease prevention in low- and middle-income countries and outline steps for making such policies accessible, effective, and transparent.
Sentinel lymph node biopsy and risk factors for predicting metastasis in cutaneous squamous cell carcinoma
Authors: J.T. Krediet, M. Beyer, K. Lenz, C. Ulrich, B. Lange-Asschenfeldt, E. Stockfleth, D. Terhorst
Journal: British Journal of Dermatology (2014)

Cutaneous squamous cell carcinoma (cSCC) is a common cancer capable of metastasis. Sentinel lymph node biopsy (SLNB) may be a valuable adjunct for patients with cSCC at high risk for metastasis. However, data on risk factors for metastasis and results of SLNB from patients with cSCC are limited.To evaluate risk factors for metastasis in patients with cSCC in a large cohort study with long-term follow-up and to determine the value of SLNB.We retrospectively analysed all records of patients who underwent excision of cSCC between January 2005 and August 2009 at a tertiary referral centre. In total, 143 patients were included in the cohort, including 17 patients with SLNB and a follow-up time of ≥ 24 months.Tumour thickness > 4 mm and recurrent cSCC were strongly associated with metastatic disease. All metastases in this cohort occurred within 24 months of follow-up. SLNB showed a low sensitivity with regard to the development of metastasis. Six of 17 patients developed metastatic disease despite a negative SLNB.Patients with risk factors (cSCC with a tumour thickness > 4 mm or recurrent disease) may develop metastases within the first 2 years despite a negative SLNB. Therefore these patients should be closely monitored during the follow-up. Based on our data SLNB does not provide diagnostic value for patients with cSCC.
Acute lung injury following lung resection: is one lung anaesthesia to blame?
Authors: E. A. Williams, T. W. Evans, P. Goldstraw
Journal: Thorax (1996)

Further examination of the parameters of oxidative stress, perioperative changes in the vasoregulatory mechanisms of the pulmonary circulation, and characterisation of the endothelial insult that probably occurs in all patients undergoing lung resection is necessary if the operative conditions under which lung surgery is carried out are to be optimised. Perhaps, then, more insight might be gained into how to improve preservation of lungs for transplantation and how to protect the lung from significant injury following resection.
TCT-594 Acute Stent Expansion in the Latest-Generation Drug-Eluting Stent Platforms: An Experimental Study Using Optical Coherence Tomography
Authors: Hideki Kitahara, Katsuhisa Waseda, Ryotaro Yamada, Kyuhachi Otagiri, Shigemitsu Tanaka, Yuhei Kobayashi, Kozo Okada, Kaori Nakagawa, Fumiaki Ikeno, Paul Yock, Peter J. Fitzgerald, Yasuhiro Honda
Journal: Journal of the American College of Cardiology (2013)
Treatment of Injury To the Root of the Nail
Authors: Simon Rodbard
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Trauma to the root of the nail is commonly followed by subungual hemorrhage which gradually dissects the root of the nail from its bed. This process can be the source of excruciating pain. If the progressive hemorrhage is permitted to compress the nail bed, the growth of the nail is interrupted and several months of discomfort and inconvenience during regrowth of the nail can be anticipated. The pain of acute subungual hemorrhage is commonly treated by decompression of the nail bed, by cutting or drilling through the nail. However, facilities or personnel for the performance of this painful procedure are seldom immediately available. I have found on two occasions that the pain can be relieved immediately, and subungual dissection can be stopped, by elevating the hand as high as possible and maintaining the hand in this position for about 30 minutes. Elevation of the hand reduces the
544 ADENOVIRUS DELIVERY OF TBRIIDCYT UP-REGULATES TRANSCRIPTIONAL REPRESSOR SNON, DECREASES MMP-2 IN HSC AND PREVENTS ESTABLISHMENT OF LIVER FIBROSIS
Authors: A.L. Marquez-Aguirre, A. Sandoval-Rodriguez, J. Gonzalez-Cuevas, M.R. Bueno-Topete, J. Armendariz-Borunda
Journal: Journal of Hepatology (2008)
Physicians' Fundamental Responsibility
Authors: John J. Coury
Journal: JAMA (1986)

On behalf of myself and my family, with both pride and humility, I assume the largest responsibility this House of Delegates can bestow on a physician. For this you have our heartfelt gratitude.  For me, this evening is the culmination of years of travel along the path of medicine. I have come to appreciate as never before this greatest of professions in which all of us have the opportunity to serve. And I have learned that we have an opportunity to leave an even far greater legacy of service than the one we have inherited. I say that because, as a profession in today's climate, ours is to remember that it is people we serve. And our legacy to the people can be the kind of medicine that assures them of better health and longer life for their todays and for their tomorrows as well. I think that's extremely important
Glucagon Immunoreactivities and Amino Acid Profile in Plasma of Duodenopancreatectomized Patients
Authors: Walter A. Muller, Michael Berger, Peter Suter, Hans J. Cüppers, Jürgen Reiter, Thomas Wyss, Peter Berchtold, Felix H. Schmidt, Jean-P. Assal, Albert E. Renold
Journal: Journal of Clinical Investigation (1979)

Glucogon immunoreactivity (IRG) was measured in plasma of duodenopancreatectomized subjects with a nonspecific (K-4023) and a specific (30-K) glucagon antiserum. After an overnight fast, plasma IRG (K-4023) was significantly (P < 0.05) higher in the subjects without pancreas, averaging 782+/-79 (SEM) pgeq/ml, than in the controls (482+/-80 pgeq/ml). IRG (30-K) of 162+/-68 pg/ml did not change during an infusion of arginine (450 mg/kg per 40 min). Insulin deprivation during 3 d in one patient did not restore the IRG response to arginine as reported in depancreatized dogs.Bio-Gel P-30 column chromatography revealed that virtually all IRG (30-K) measured in whole plasma was of different molecular weight than glucagon, and primarily of a mol wt >/= 40,000. Intravenous arginine did not significantly alter the chromatographic pattern of these plasmas. Thus, as postulated by others, duodeno-pancreatectomized humans have virtually no circulating 3,500-dalton glucagon. Hence, the presence of 3,500-dalton glucagon in plasma is not a condition for the diabetic state. It might, nevertheless, when present in normal or excessive amounts, worsen the metabolic state of diabetic patients. Among 14 amino acids measured in plasma of these patients, the concentrations of alanine, serine, ornithine, and arginine were significantly (P < 0.05) elevated to approximately twice that of normal: alanine and serine are both substrates for gluconeogenesis, whereas ornithine and arginine are involved in the formation of urea, the second product of hepatic gluconeogenesis. As the concentrations of branched chain amino acids were not grossly altered, it is hypothesized that this amino acid pattern is a consequence of glucagon deficiency rather than secondary to the diabetic state of these patients.
Valuation of life in long run health care programmes.
Authors: R R West
Journal: BMJ (1985)

Evaluation of the costs and benefits of health care services involves techniques for valuing human life. The human capital approach assigns an individual an economic value represented by potential future earnings. This classic human capital valuation approach is compared with a modified model in which the cumulative economic benefit of an individual is figured as a function of age, with net consumption of goods in early life and old age being compared with net production during the middle years. Discounting of benefits is explained and shown to have produced nonsensical results in a genetic screening application. The modified human valuation model is especially useful in estimating the value of a newborn. This model suggests that screening for neural tube defects or Down's syndrome, and then preventing the birth of those afflicted through selective abortion, is more cost beneficial than previous estimates have indicated.
Group B Streptococcal Urinary Tract Infection in an Infant
Authors: Ziad Shehab
Journal: JAMA (1979)

To the Editor.—  We read St Laurent-Gagnon and Weber's report of a 6-week-old infant with group B streptococcal urinary tract infection (240:1269, 1978). At the time of the article's publication, we were treating a 3-week-old infant with a similar infection.  Report of a Case.—  The baby was the product of a full-term, uncomplicated pregnancy, and his birth weight was 4,400 g. His neonatal course was uncomplicated, and he was discharged at the age of 3 days. He had done well until 24 hours before admission, when fever, vomiting, loose stools, and irritability developed. The 4.4-kg patient had a height and weight at the 50th percentile. His temperature was 39.2 °C; blood pressure was 80 mm Hg by palpation. The findings from his examination were otherwise unremarkable. Laboratory study values included a hematocrit reading of 38% and a WBC count of 15,600/cu mm, with two juvenile cells, 17 band forms,
THE USE OF METASTRON IN A MULTI-DISCIPLINARY PAIN CLINIC ENVIRONMENT
Authors: D. A. Podoloff, N. A. Janjan, H. I. Libshitz, T. A. Gillis, R. Payne, A. W. Yasko, C. G. Martin, W. F. Broussard
Journal: Clinical Nuclear Medicine (1997)

Podoloff, D. A.; Janjan, N. A.; Libshitz, H. I.; Gillis, T. A.; Payne, R.; Yasko, A. W.; Martin, C. G.; Broussard, W. F. Author Information
Clinical Trials — Are They Ethical?
Authors: E Passamani
Journal: New England Journal of Medicine (1991)

Biomedical research leads to better understanding of biology and ultimately to improved health. Physicians have for millenniums attempted to understand disease, to use this knowledge to cure or palliate, and to relieve attendant suffering. Improving strategies for prevention and treatment remains an ethical imperative for medicine. Until very recently, progress depended largely on a process of carefully observing groups of patients given a new and promising therapy; outcome was then compared with that previously observed in groups undergoing a standard treatment. Outcome in a series of case patients as compared with that in nonrandomized controls can be used to assess . . .
Urinary tract infections in women: diagnosis and management in primary care
Authors: Josip Car
Journal: BMJ (2006)

<i>Urinary tract infections are the second most common infections, causing considerable anxiety and morbidity in women. Care is not always optimal—prophylaxis is rarely considered and unnecessary investigations are requested. This evidence based approach to management of urinary tract infections in women highlights that some common recommendations, such as postcoital voiding, have no evidence base</i>
Procedures of Unproved Value
Authors: Dennis P. Burkitt
Journal: JAMA (1982)

Medical history is full of instances where previously accepted therapies and investigative practices have been rightly discarded after their ineffectiveness has been demonstrated. Regrettably, a few procedures of unproved value still linger in many hospitals. Paramount among these are the time-honored and time-consuming routine nursing procedures of counting respiration rates on all patients twice daily, and preoperative administration of enemas whether or not large-bowel surgery is contemplated. The recommended abolition of the former procedure does not of course belittle its value when specifically required and accurately performed. These procedures have been or are in the process of being abandoned in most other economically developed countries. In light of experience in East Africa, the author made a largely unheeded plea for their abandonment to both the medical<sup>1</sup>and nursing<sup>2</sup>professions more than 15 years ago. <h3>Routine Twice-Daily Respiration Counts</h3> At a time when a nurse's observations were almost limited to
Growth Inhibition of Murine Melanoma and Human Colon Carcinoma by Recombinant Human Platelet Factor 4
Authors: R. J. Sharpe, H. R. Byers, C. F. Scott, S. I. Bauer, T. E. Maione
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Growth Inhibition of Murine Melanoma and Human Colon Carcinoma by Recombinant Human Platelet Factor 4 Get access Richard J. Sharpe, Richard J. Sharpe * Repligen CorporationCambridge, MADepartment of Dermatology, Harvard Medical School and Beth Israel HospitalBoston, MA * Correspondence to: Richard J. Sharpe, M.D., Repligen Corporation, One Kendall Square, Bldg. 700, Cambridge, MA 02139. Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Randolph Byers, H. Randolph Byers Department of Pathology, Harvard Medical School and Massachusetts General HospitalBoston, MA Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles F. Scott, Charles F. Scott Repligen CorporationCambridge, MA Search for other works by this author on: Oxford Academic PubMed Google Scholar Susan I. Bauer, Susan I. Bauer Repligen CorporationCambridge, MA Search for other works by this author on: Oxford Academic PubMed Google Scholar Theodore E. Maione Theodore E. Maione Repligen CorporationCambridge, MA Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 10, 16 May 1990, Pages 848–853, https://doi.org/10.1093/jnci/82.10.848 Published: 16 May 1990 Article history Received: 14 December 1989 Revision received: 02 February 1990 Accepted: 28 February 1990 Published: 16 May 1990
Diabetes and Cancer: A Consensus Report
Authors: E. Giovannucci, D. M. Harlan, M. C. Archer, R. M. Bergenstal, S. M. Gapstur, L. A. Habel, M. Pollak, J. G. Regensteiner, D. Yee
Journal: CA A Cancer Journal for Clinicians (2010)

Epidemiologic evidence suggests that cancer incidence is associated with diabetes as well as certain diabetes risk factors and treatments. This consensus statement of experts assembled jointly by the American Diabetes Association and the American Cancer Society reviews the state of science concerning 1) the association between diabetes and cancer incidence or prognosis; 2) risk factors common to both diabetes and cancer; 3) possible biologic links between diabetes and cancer risk; and 4) whether diabetes treatments influence the risk of cancer or cancer prognosis. In addition, key unanswered questions for future research are posed.
Effects of paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on refractory vasovagal syncope: a randomized, double-blind, placebo-controlled study
Authors: Enrico Di Girolamo, Cesare Di Iorio, Panfilo Sabatini, Luigi Leonzio, Carmela Barbone, Antonio Barsotti
Journal: Journal of the American College of Cardiology (1999)
Complete Remissions in Hairy Cell Leukemia with 2-Chlorodeoxyadenosine after Failure with 2-Deoxycoformycin
Authors: Alan Saven
Journal: Annals of Internal Medicine (1993)

Objective: To determine whether clinical cross-resistance and intolerance exists between the nucleosides 2-deoxycoformycin (DCF) and 2-chlorodeoxyadenosine (2-CdA) in the treatment of patients with hairy cell leukemia despite similar structures and mechanisms of action. Design: Phase II clinical study. Setting: Referral cancer center. Participants: Five patients with hairy cell leukemia who had been previously treated with DCF. Intervention: Single course of 2-CdA at 0.1 mg/kg body weight per day for 7 days by continuous intravenous infusion. Results: Of five patients, three were resistant to and two were intolerant of (having had life-threatening toxic reactions) DCF therapy. Four patients obtained a complete response with a median follow-up period of more than 11 months. The other patient in whom splenectomy, interferon, and DCF treatments were unsuccessful had a partial response lasting 2 months and subsequently died of Streptococcus pneumoniae bacteremia. Three of the four patients with complete responses remain in unmaintained remission, whereas the fourth has progressive splenic enlargement with stable hematologic parameters. The median leukocyte count increased from 2.0 109/L to 3.8 109/L, the median absolute neutrophil count increased from 0.56 109/L to 2.73 109/L, the median hemoglobin level increased from 112 g/L to 140 g/L, and the median platelet count increased from 55 109/L to 123 109/L. Two patients had culture-negative neutropenic fever associated with treatment. Conclusions: 2-Chlorodeoxyadenosine induced complete responses in patients with hairy cell leukemia resistant to DCF, suggesting a lack of cross-resistance. Also, 2-CdA is not prohibitively toxic in patients intolerant of DCF.
A Simple Oral Gastric Secretory Stimulant (Betazole Hydrochloride)
Authors: Charles B. Clayman
Journal: JAMA (1961)

BETAZOLE hydrochloride (Histalog), a synthetic analog of histamine, has been employed for the past 6 years as the parenteral stimulant to gastric acid secretion in the standard 2-hour gastric analysis employed by this clinic. 1 With proper intragastric placement of the tube, doses of 0.1 mg. per kg. of body weight have been equal in potency to the previously employed 0.01 mg. per kg. of histamine diphosphate. The chief advantage has been the almost complete disappearance of headache and flushing, frequent and occasionally troublesome side effects following injection of histamine.  Three years ago the oral preparation of betazole hydrochloride was made available and a comparison of the two forms of administration was undertaken. The purpose of this report is to compare the effectiveness of oral and intramuscular betazole hydrochloride as a stimulant to gastric acid secretion.  Method  Each subject was studied by the standard 2-hour gastric analysis. 2 The
Tribute to a Master's Work — A 24-Year Follow-up
Authors: Samir R Kapadia, Maria Schlumpf
Journal: New England Journal of Medicine (2004)

In April 1978, Dr. Andreas Gruntzig, of University Hospital, Zurich, told a patient who had a tightly narrowed left anterior descending coronary artery that he did not have enough experience to cite an accurate success rate for balloon angioplasty of this artery before he performed the procedure. He said that the patient was only his eighth, and his first from the United States, to undergo this procedure. Panel A shows the angiogram from 1978. The left-hand image shows a lesion in the proximal left anterior descending coronary artery (arrow), the middle image shows the balloon inflation, and the right-hand image . . .
THE CLINICAL SYMPTOMS, BACTERIOLOGIC FINDINGS AND POSTMORTEM APPEARANCES IN CASES OF INFECTION OF HUMAN BEINGS WITH THE BACILLUS PYOCYANEUS.
Authors: LEWELLYS F. BARKER
Journal: JAMA (1897)

<h3>[ABSTRACT.]</h3><h3>[From the Pathological Laboratory of the Johns Hopkins Hospital and University.]</h3> The literature of the bacillus pyocyaneus with especial reference to its pathogenic effects in human beings was reviewed. Especial reference was made to the experimental work of Charrin on animals and to the human infections reported by Oettinger, Ehlers, Jad kewitch, Neumann, Schaefer, Karlinsky, Ledderhose-Jakowski, Gruber, Martha, Krannhals, Calmette, Mon, nier, Ernst, Fowler, Adami and Williams, Kossel-Blumer, Williams and Cameron, Lavender, Pes and, Gradenigo, and Le Noir. There can no longer be any doubt that in addition to the more or less accidental appearance of blue pus in surgical cases that the bacillus pyocyaneus is capable of entering the human organism and setting up disease processes of variable intensity sometimes of a violence leading to a fatal issue. The writer reported eleven such cases which had come under his personal observation. These eleven cases were independent of the
Obesity and adiposity indicators, asthma, and atopy in Puerto Rican children
Authors: Erick Forno, Edna Acosta-Pérez, John M Brehm, Yueh-Ying Han, María Alvarez, Angel Colón-Semidey, Glorisa Canino, Juan C Celedón
Journal: Journal of Allergy and Clinical Immunology (2013)
Upper Gastrointestinal Bleeding from the Biliary Tract (Hematobilia) Detection by Technetium-99m DTPA
Authors: A R AL-SUHAILI, S ERICSSON, R H BAHAR, M K NAWAZ, H M ABDEL-DAYEM
Journal: Clinical Nuclear Medicine (1987)

A case of hematobilia causing upper gastrointestinal bleeding is demonstrated by Tc-99m DTPA. The advantages of Tc-99m DTPA over Tc-99m sulfur colloid and RBCs are discussed.