Serum Amyloid A Protein in Familial Mediterranean Fever
Authors: AARON KNECHT
Journal: Annals of Internal Medicine (1985)

Brief Reports1 January 1985Serum Amyloid A Protein in Familial Mediterranean FeverAARON KNECHT, M.D., FREDERICK C. de BEER, M.D., MORDECHAI PRAS, M.D.AARON KNECHT, M.D.Search for more papers by this author, FREDERICK C. de BEER, M.D.Search for more papers by this author, MORDECHAI PRAS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-1-71 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAmyloid a protein is the subunit of amyloid fibrils that occurs in the forms of amyloidosis commonest in humans and ubiquitous in animals (1, 2). Its unique nature prompted a search for its substrate in normal serum and led to the discovery, by immunologic techniques, of serum amyloid A protein (3, 4), a high-density apolipoprotein that behaves like an acute-phase reactant and has an aminoterminal identical with that of amyloid A protein.The first complete amino acid sequence of amyloid A protein came from a sample of amyloid from a patient with familial Mediterranean fever. A rise in serum levels...References1. LEVINFRANKLINFRANGIONEPRAS MEBM. The amino acid sequence of the major nonimmunoglobulin component of some amyloid fibrils. J Clin Invest. 1972;51:2773-6. CrossrefMedlineGoogle Scholar2. PRASGAFNI MJ. The nature of amyloid. In: GLYNN LE, STEWARD MW, eds. Immunochemistry: An Advanced Textbook. London: John Wiley & Sons Ltd.; 1977:509-33. Google Scholar3. LEVINPRASFRANKLIN MME. Immunologic studies of the major nonimmunoglobulin protein of amyloid: I. Identification and partial characterization of a related serum component. J Exp Med. 1973;138:373-80. CrossrefMedlineGoogle Scholar4. ROSENTHALFRANKLIN CE. Variation with age and disease of an amyloid A protein-related serum component. J Clin Invest. 1975;55:746-53. CrossrefMedlineGoogle Scholar5. SOHARGAFNIPRASHELLER EJMH. Familial Mediterranean fever: a survey of 470 cases and review of the literature. Am J Med. 1967;43:227-53. CrossrefMedlineGoogle Scholar6. ZEMERREVACHPRAS DMM. A controlled trial of colchicine in preventing attacks of familial Mediterranean fever. N Engl J Med. 1974;291:932-4. CrossrefMedlineGoogle Scholar7. DE BEERDYCKPEPYS FRM. Solid-phase immunoradiometric assay for serum amyloid A protein using magnetisable cellulose particles. J Immunol Methods. 1982;52:213-21. CrossrefMedlineGoogle Scholar8. CHAMBERSWHICHER RJ. Standardistion of assay for SAA. In: TRIBE CR, BACON PA, eds. Amyloidosis: Proceedings of the First European Amyloidosis Research Symposium, 1981. Bristol: John Wright & Sons; 1983:8. Google Scholar9. PRASBRONSHPIGELZEMERGAFNI MNDJ. Variable incidence of amyloidosis in familial Mediterranean fever among different ethnic groups. Johns Hopkins Med J. 1982;150:22-6. MedlineGoogle Scholar10. SKOGENSLETTENLEANATVIG BKTJ. Heterogeneity of human amyloid protein AA and its related serum protein, SAA. Scand J Immunol. 1983;17:83-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Heller Institute of Medical Research Tel-Aviv University Tel-Hashomer Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCan Serum Fetuin-A Be Regarded as an Inflammatory Marker Among Patients with Familial Mediterranean Fever?Tumor Necrosis Factor-α Gene Polymorphisms in FMF and Their Association With AmyloidosisChronic inflammation in FMF: markers, risk factors, outcomes and therapyThe Effect of Plasminogen Activator Inhibitor-1 -675 4G/5G Polymorphism on Familial Mediterranean Fever (FMF) DiseaseCurrent perspectives on familial Mediterranean feverSuccessful treatment of familial Mediterranean fever with Anakinra and outcome after renal transplantationThe evaluation of carotid intima-media thickness in children with familial Mediterranean feverIs Familial Mediterranean Fever a thrombotic disease or not?Maladie périodique, symptomatologie clinique et biologiqueLa maladie périodique au sein des maladies auto-inflammatoiresAbdominal and Digestive System Associations of Familial Mediterranean FeverMolecular Mechanisms of AmyloidosisAtherosclerosis and Familial Mediterranean FeverThe relation between familial Mediterranean fever and amyloidosisClinical Spectrum of Familial Hibernian Fever: A 14-Year Follow-Up Study of the Index Case and Extended FamilyThe changing face of Familial Mediterranean FeverSerum soluble interleukin-2 receptor levels in familial Mediterranean fever.Sequence analysis of amyloid protein AA from a Turkish patient with familial Mediterranean fever: Documentation of its SAA 1α derivationBiologic and clinical advances in familial Mediterranean feverQuantification and mapping of antigenic determinants of serum amyloid A (SAA) protein utilizing sequence-specific immunoglobulins and Eu3+ as a specific probe for time-resolved fluorometric immunoassayCOLCHICINE TREATMENT OF AA AMYLOIDOSIS OF FAMILIAL MEDITERRANEAN FEVERColchicine in the treatment of AA and AL amyloidosisFamilial Mediterranean Fever-Associated AmyloidosisThe arthritis of familial mediterranean feverAutosomal dominant ‘Mediterranean fever’ in a Finnish familySpectrum of renal involvement in familial Mediterranean feverRecurrent Hereditary Polyserositis or Familial Mediterranean Fever: An OverviewAmyloses — Aspects biochimiquesRenal amyloidosis complicating sarcoidosis.Structure and Variation in the Human Serum Amyloid A Gene FamilyColchicine in the Prevention and Treatment of the Amyloidosis of Familial Mediterranean FeverThe Hereditary Amyloidoses 1 January 1985Volume 102, Issue 1Page: 71-72KeywordsAcute phase proteinsAmino acidsAmyloid proteinsAmyloidosisApolipoproteinsBlood banksFeversResearch grantsSerum proteins Issue Published: 1 January 1985 PDF downloadLoading ...