tbuckley/cabot-search huggingface dataset:
Acute Tuberculosis and Granulocytic Disorders
Authors: N. C. Oswald
Journal: BMJ (1963)

During the past 60 years the possibility that a special relation exists between tuberculosis and haematological abnormalities has occupied the thoughts of many investi gators. Most of the early observations were made in German-speaking countries and were summarized in 1939 by Siegmund. Among the original descriptions were instances of a particularly acute form of tuberculous miliary necrosis with depressed blood formation which varied from a simple leucopenia affecting mainly the granulocytes to agranulocytosis and pancytopenia. Other authors noted the development of acute tuberculosis in patients with myeloid leukaemia. Later writers have con firmed these findings but have failed to agree upon the extent to which the tuberculosis may influence the behaviour of the bone-marrow. For example, the haemato logical changes that occasionally accompany acute tuber culosis may resemble acute leukaemia in that primitive white cells appear in the blood and marrow, but at post mortem examination no conclusive evidence of leukaemia can be found, there being no leukaemic infiltration of the tissues. Sometimes, when the blast cells are particularly numerous, an underlying acute leukaemia is presumed, and indeed would probably be diagnosed as such were it not for the tuberculosis. At other times the abnormal white cells are less primitive and a so-called leukaemoid reaction is suspected.
Visualization of Tissue Prolapse Between Coronary Stent Struts by Optical Coherence Tomography
Authors: Ik-Kyung Jang, Guillermo Tearney, Brett Bouma
Journal: Circulation (2001)

IVUS (A) and OCT (B) images of the stented right coronary artery are shown.Although IVUS showed a well-deployed stent, the detailed structure around the stent struts is not well visualized.In addition, OCT clearly visualized tissue prolapse between the stent struts (12 to 3 o'clock).The tissue prolapse occurred mainly in an area with lower OCT signal intensity, which is suggestive of a plaque with a large lipid content.
Selective immunosuppression by administration of major histocompatibility complex class II-binding peptides. II. Preventive inhibition of primary and secondary in vivo antibody responses.
Authors: J C Guéry, M Neagu, G Rodriguez-Tarduchy, L Adorini
Journal: The Journal of Experimental Medicine (1993)

The self-mouse lysozyme peptide corresponding to residues 46-62 (ML46-62) binds to the major histocompatibility complex (MHC) class II molecules I-A(k) and it selectively inhibits, when coinjected with antigen, priming of I-A(k)-restricted, antigen-specific T cells. We demonstrate that administration of ML46-62 also inhibits in vivo antibody responses induced by I-A(k)-restricted T helper cells. ML46-62 is able to prevent the primary anti-hen egg white lysozyme (HEL) antibody response induced by the entire HEL molecule in B10.A(4R) mice, expressing only I-A(k) molecules, but not in mice of H-2d haplotype. ML46-62 also strongly decreases, in B10.A(4R) mice, the antibody response to ribonuclease A, a protein antigen unrelated to the MHC blocker, indicating that MHC blockade is the mechanism leading to inhibition of antibody response. This is further supported by the concomitant decrease, in vivo, of complex formation between immunodominant HEL peptides and I-A(k) molecules, preventing I-A(k)-restricted T cell induction. Administration of ML46-62 after antigen priming does not affect ongoing antibody responses, as expected from MHC blockade. A single injection of ML46-62 at the time of protein antigen priming precludes not only the primary, but also the secondary antibody response to a subsequent challenge with soluble protein, even when the challenge is performed several months after priming. Coinjection of antigen and MHC antagonist inhibits production of all antibody isotypes equally well, suggesting that MHC class II blockade affects both Th1- and Th2-type T helper cells. Therefore, these results indicate that administration of MHC class II-binding peptides can efficiently and selectively prevent the induction of T cell-dependent primary and secondary in vivo antibody responses by blocking antigen presentation to class II-restricted T helper cells.
Dutch system of peer review is different and effective
Authors: P. Bourdillon
Journal: BMJ (1999)

EDITOR—Much has been written in the past two years about continuing medical education (see the series that began in January last year1), peer review,2 and revalidation.3 Despite this I have not seen any mention of the Dutch system of peer review, which has been running for five years (S van der Baan, conference of the Dutch Ear-Nose-Throat Society, March 1998).

Each specialist is required to belong to a group of four to eight like-minded specialists,which …
1-ALPHA-HYDROXYCHOLECALCIFEROL AS A SUBSTITUTE FOR THE KIDNEY HORMONE 1,25-DIHYDROXYCHOLECALCIFEROL IN CHRONIC RENAL FAILURE
Authors: T.M. Chalmers, M.W. Davie, J.O. Hunter, K.F. Szaz, B. Pelc, E. Kodicek
Journal: The Lancet (1973)
Chronic Alcoholics as Drinking Drivers
Authors: Horage E. Campbell
Journal: JAMA (1962)

<h3>To the Editor:—</h3> Police records are replete with instances of drivers convicted again and again of driving while intoxicated. These records reveal that drivers, after an arbitrary length of time, are allowed their licenses, until finally they kill some other driver or themselves. It is finally coming to be realized that many of these drivers are chronic alcoholics. The chronic alcoholic, or problem drinker, is completely immune to slogans. Safety campaigns do not touch him at all. Scathing lectures by judges, even terms in jail, are just water on this duck's back. He is a compulsive drinker. Repetitive offenders should be sentenced to psychiatric investigation. Increasingly, traffic courts must have good, closely related psychiatric clinics. Detroit's Recorder's Court was the first of these and is still the best. The numbers of feeble-minded, psychotic, alcoholic, emotionally deranged, licensed drivers revealed by this clinic is appalling. If investigation reveals a chronic alcoholic,
Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL
Authors: Belinda Austen, Judith E. Powell, Azra Alvi, Ian Edwards, Laura Hooper, Jane Starczynski, A. Malcolm R. Taylor, Christopher Fegan, Paul Moss, Tatjana Stankovic
Journal: Blood (2005)
Low recurrence rates for in situ and invasive melanomas using Mohs micrographic surgery with melanoma antigen recognized by T cells 1 (MART-1) immunostaining: Tissue processing methodology to optimize pathologic staging and margin assessment
Authors: Jeremy Robert Etzkorn, Joseph F. Sobanko, Rosalie Elenitsas, Jason G. Newman, Hayley Goldbach, Thuzar M. Shin, Christopher J. Miller
Journal: Journal of the American Academy of Dermatology (2015)
Cardiopulmonary-Cerebral Resuscitation
Authors: Frank M. Yatsu
Journal: New England Journal of Medicine (1986)

The hypothesis that the brain can be protected from irreversible anoxic or ischemic damage by the use of pharmacologic agents given shortly after the insult is an old one. This hypothesis is ambitiously tested in the study by Abramson et al. reported in this issue of the Journal.1 In this study high-dose thiopental was administered to comatose patients after cardiopulmonary resuscitation, in the hope that the drug would lower metabolic demands and thus protect the brain, but the results were negative. Until newer investigations prove the contrary, the use of barbiturates cannot be justified to avert irreversible anoxic or . . .
Pott??s Puffy Tumor: Scintigraphic Findings
Authors: ROGER F. UREN, ROBERT HOWMAN-GILES
Journal: Clinical Nuclear Medicine (1992)

The authors describe the scintigraphic findings of bone and Ga-67 imaging performed on three patients thought to have Pott's puffy tumor. Two patients did indeed have it, but the third patient's "puffy tumor" was a soft tissue abscess.
Early restaging positron emission tomography with 18F-fluorodeoxyglucose predicts outcome in patients with aggressive non-Hodgkin’s lymphoma
Authors: K. Spaepen, S. Stroobants, P. Dupont, P. Vandenberghe, J. Thomas, T. de Groot, J. Balzarini, C. De Wolf-Peeters, L. Mortelmans, G. Verhoef
Journal: Annals of Oncology (2002)
KDIGO clinical practice guideline for the care of kidney transplant recipients: a summary
Authors: Bertram L. Kasiske, Martin G. Zeier, Jeremy R. Chapman, Jonathan C. Craig, Henrik Ekberg, Catherine A. Garvey, Michael D. Green, Vivekanand Jha, Michelle A. Josephson, Bryce A. Kiberd, Henri A. Kreis, Ruth A. McDonald, John M. Newmann, Gregorio T. Obrador, Flavio G. Vincenti, Michael Cheung, Amy Earley, Gowri Raman, Samuel Abariga, Martin Wagner, Ethan M. Balk
Journal: Kidney International (2009)
Reporting of AIDS: Tracking HIV Morbidity and Mortality
Authors: James W. Buehler
Journal: JAMA (1989)

Physicians and other health care providers have reported more than 110 000 cases of the acquired immunodeficiency syndrome (AIDS) to local and state health departments in the United States since 1981, including 34 000 in the past 12 months alone. Surveillance of AIDS in the United States accounts for nearly 60% of cases reported to the World Health Organization by 152 nations,<sup>1</sup>reflecting both the extent of the human immunodeficiency virus (HIV) epidemic in this country and the completeness of our reporting compared with that of other nations. Earlier in this decade, reports of AIDS cases in homosexual men, intravenous drug users, their heterosexual partners, transfusion recipients, and infants defined the principal modes of HIV transmission, well in advance of the discovery of HIV. More recently, AIDS surveillance has documented the spread of the epidemic beyond the major coastal centers, the striking disparity in the AIDS burden among blacks
Rheumatoid factor-producing cells detected by direct hemolytic plaque assay.
Authors: J H Vaughan, T Chihara, T L Moore, D L Robbins, K Tanimoto, J S Johnson, R McMillan
Journal: Journal of Clinical Investigation (1976)

Lymphocytes secreting anti-IgC antibodies, rheumatoid factors (RF), can be detected in the peripheral bloods, synovial fluids, and bone marrows of patients with seropositive rheumatoid arthritis by using a direct plaque-forming cell (PFC) assay with sheep erythrocytes sensitized with reduced and alkylated rabbit IgG hemolysin. The autospecific nature of the RF produced by RF-PFC was indicated by inhibition studies in which the order of patency was human IgG greater than rabbit IgG greater than bovine IgG. In metabolic studies puromycin, cycloheximide, and venblastine suppressed RF-PFC. Cyclic AMP and cyclic GMP were without effect. A need was recognized for using full tissue culture media during the cell separation and plaquing procedures to optimize detection of the RF-PFC. RF-PFC may appear in the blood of patients intermittently despite their continuing presence in the bone marrow. They have been found in the peripheral blood, especially during acutely exacerbating polyarticular synovitis, generalized vasculities, or generally active, aggressive disease. RF-PFC were found in synovial effusions of new or recrduescent acute synovitis. RF-PFC were observed to disappear from the peripheral circulation and the bone marrow during therapy with cytotoxic drugs. The data are consistent with the hypothesis that the appearance of RF-PFC in the peripheral blood represents an anamnestic response to transiently appearing antigen. The nature of the antigen is not specified. The bone marrow may be a site of origin of RF-PFC.
Clinical and Metabolic Studies with Imipramine in Man
Authors: PHILLIP ZEIDENBERG, RALPH N. WHARTON, JAMES M. PEREL, MAUREEN KANZLER, SIDNEY MALITZ
Journal: American Journal of Psychiatry (1971)

Six out of seven severely depressed patients improved rapidly on very high doses of imipramine. Clinical improvement correlated well with drug blood levels, which varied greatly from patient to patient and were characteristic of individual patients rather than of dose. Three out of five of the same patients receiving a combination of presumptive inhibitors of drug-metabolizing enzymes and imipramine had drug blood levels comparable to those of two patients receiving high doses of imipramine alone. Further study is underway to clarify the human pharmacology of these two therapies.
Timeliness of Diagnosis of Asthma in Children and Associated Factors
Authors: W.E. Molis, H. Kita, L.A. Lee, R.J. Maki, R. Smith, T. Chang, A. Weaver, V. Pankratz, R.M. Jacobson, G.A. Poland, Y.J. Juhn
Journal: Journal of Allergy and Clinical Immunology (2006)
Integrating Addiction Medicine Into Graduate Medical Education in Primary Care: The Time Has Come
Authors: Patrick G. O'Connor, Julie G. Nyquist, A. Thomas McLellan
Journal: Annals of Internal Medicine (2011)

Substance use disorders create an enormous burden of medical, behavioral, and social problems and pose a major and costly public health challenge. Despite the high prevalence of substance use and its consequences, physicians often do not recognize these conditions and, as a result, provide inadequate patient care. At the center of this failure is insufficient training for physicians about substance use disorders. To address this deficit, the Betty Ford Institute convened a meeting of experts who developed the following 5 recommendations focused on improving training in substance abuse in primary care residency programs in internal medicine and family medicine: 1) integrating substance abuse competencies into training, 2) assigning substance abuse teaching the same priority as teaching about other chronic diseases, 3) enhancing faculty development, 4) creating addiction medicine divisions or programs in academic medical centers, and 5) making substance abuse screening and management routine care in new models of primary care practice. This enhanced primary care residency training should represent a major step forward in improving patient care.
Do Obese Persons Mirror Thin Counterparts in Calorie Intake, Recall of Food Consumed?
Authors: Chris Anne Raymond
Journal: JAMA (1988)

AFTER YEARS of being accused of being lazy or untruthful in reporting food consumption, obese persons' reputations are being vindicated. A study at Memphis (Tenn) State University finds fat people no less accurate in their recall of food consumption than thin people, nor—and this may be more surprising— more likely to eat more. This study follows on the heels of two others published earlier this year that showed that some obese persons may in fact be overweight because of a sluggish metabolism (<i>N Engl J Med</i>1988; 318:461-472). Numerous surveys of dietary intake, including the National Health and Nutrition Examination Survey, indicated that normal-weight and overweight persons ingest about the same number of calories (<i>J Chronic Dis</i>1985;38:727732). In fact, in some studies, obese persons said they ate less. "Either the obese truly are not eating more, or they're lying," says Robert C. Klesges, PhD, a Memphis State associate professor
Long-Term Follow-Up of Patients With Long-QT Syndrome Treated With β-Blockers and Continuous Pacing
Authors: Parvin C. Dorostkar, Michael Eldar, Bernard Belhassen, Melvin M. Scheinman
Journal: Circulation (1999)

The long-QT syndrome is associated with sudden cardiac death. Combination of beta-blocker and pacing therapy has been proposed for treatment of drug-resistant patients. The purpose of this study was to summarize our long-term experience with combined therapy in patients with long-QT syndrome.A total of 37 patients with idiopathic long-QT syndrome were treated with combined therapy consisting of continuous cardiac pacing and maximally tolerated beta-blocker therapy and followed up for 6.3+/-4. 6 years (mean+/-SD). The group consisted of 32 female and 5 male patients with a mean age of 31.6 years. The mean paced rate was 82+/-7 bpm (range, 60 to 100 bpm). On follow-up, recurrent symptoms caused by pacemaker malfunction were documented in 3 patients. Four patients died during the follow-up period: 2 adolescents stopped beta-blocker therapy, 1 patient died suddenly while treated with combined therapy, and 1 patient died of unrelated causes. In addition, 3 patients had resuscitated cardiac arrest while on combined therapy, and 1 patient had repeated, appropriate implantable cardioverter-defibrillator discharges on follow-up.Because 28 of 37 patients remain without symptoms with beta-blocker therapy and continuous pacing, combined therapy appears to provide reasonable, long-term control for this high-risk group. However, the incidence of sudden death and aborted sudden death (24% in all patients and 17% in compliant patients) strongly suggests the use of a "back-up" defibrillator, particularly in noncompliant adolescent patients. Implantable cardioverter-defibrillator therapy, however, may be associated with recurrent shocks in susceptible patients.
Dermal Abrasion-Reply
Authors: Joseph J. Eller
Journal: JAMA (1963)

<h3>To the Editor:—</h3> Dr. Thale seems much disturbed over the use of the phrase "removal of scars." From our experience with this technique in many hundreds of cases over a period of 15 years, we see nothing wrong in using the expression "removal or elimination of scars," since we have found that this can be done in the majority of cases. We often remove shallow acne scars with one dermal abrasion, while the deeper ones may need this procedure repeated two or three times at intervals of 6 months to 1 year. There is always a definite improvement after each abrasion treatment. Dr. Thale admits that the number of abrasions necessary depends on the extent of scarring. Dr. Thale lists a number of complications and untoward reactions. From our own experience we have encountered them rarely. In fact, the only complications we have seen have been temporary pigmentations, including temporary
Lymphoma Syndrome in Northern Nigeria
Authors: C. G. Berry
Journal: BMJ (1964)

Heyningen 1964).There thus exists at least the theoretical possibility of prevention, or delay in maturation, of cataract in some patients, by early diagnosis and scrupulous control of the diabetes.Some 16,750 patients over 45 have a cataract extracted each year in England and Wales (Sorsby, 1962).If 13% of these are diabetics, the annual number of operations on diabetics is 2,180.At least 3 % of all patients having a senile cataract extracted are previously undiscovered diabetics (Table IV).Thus some 440 diabetics will be diagnosed each year in England and Wales on account of cataract alone.Routine urine-testing of all patients with senile cataract, on their first attendance and on as many subsequent occasions as possible, would seem obligatory, together with detailed investigation of any with even a trace of reducing substance in their urine. SummaryA review has been made of 1,485 cataract extractions carried out in the Oxford Eye Hospital in the years 1957-62.First operations for senile cataract numbered 1,024, and 110 (10.7%) of these were on diabetics.Diabetes was found as a result of cataract in 31 (28%) of the 110 diabetics, or 3 /' of all patients having a senile cataract extracted.A total of 454 patients lived within a defined area.Of these, 13% were diabetics, and 8.8% previously known diabetics.Extraction of a senile cataract was calculated to be four to six times more frequent in known diabetics than in non-diabetics.Senile cataract in known diabetics tends to be associated with diabetes of long duration.The degree of control of diabetes in patients having a cataract extracted was worse than the average in those attending a diabetic clinic.These findings are briefly discussed in the light of the known peculiarities of glucose metabolism in the lens.
Safety of Long-Acting β-Agonists
Authors: Dermot Ryan
Journal: Annals of Internal Medicine (2006)

Letters7 November 2006Safety of Long-Acting β-AgonistsDermot Ryan, MB, BCh, BAODermot Ryan, MB, BCh, BAOFrom University of Aberdeen, Aberdeen, Scotland, United Kingdom.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-9-200611070-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: Salpeter and colleagues (1) seem to suggest that the cause for increased mortality from asthma is the use of LABAs. This class of medication became available in the United Kingdom in 1990 with the advent of salmeterol. Since that time, asthma mortality rates have decreased from approximately 2000 deaths per year to 1300 deaths per year against a context of increased prevalence of asthma. Note that the advice in the United Kingdom is not to prescribe LABAs without a concomitant prescription for inhaled corticosteroids, whereas in Salpeter and colleagues' meta-analysis, only 53% of patients in active or ...Reference1. Salpeter SR, Buckley NS, Ormiston TM, Salpeter EE. Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths. Ann Intern Med. 2006;144:904-12. [PMID: 16754916] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Aberdeen, Aberdeen, Scotland, United Kingdom.Disclosures: Dr. Ryan has received sponsorship from, has provided consultancy to, and has lectured for AstraZeneca, Altana Pharma, Boehringer Ingelheim, Pfizer Inc., GlaxoSmithKline, Merck Sharp & Dohme, Schering-Plough, Novartis, Ivax, and Trinity–Chiesi Pharmaceuticals. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-Analysis: Effect of Long-Acting β-Agonists on Severe Asthma Exacerbations and Asthma-Related Deaths Shelley R. Salpeter , Nicholas S. Buckley , Thomas M. Ormiston , and Edwin E. Salpeter Safety of Long-Acting β-Agonists Stuart W. Stoloff Safety of Long-Acting β-Agonists Shelley R. Salpeter Safety of Long-Acting β-Agonists Graeme P. Currie Safety of Long-Acting β-Agonists Mats Jacob Lindberg Safety of Long-Acting β-Agonists Harold S. Nelson and Paul M. Dorinsky Metrics 7 November 2006Volume 145, Issue 9Page: 707KeywordsAsthmaConflicts of interestDeath ratesFearHealth careSafetySteroids ePublished: 7 November 2006 Issue Published: 7 November 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Metastatic Cardiac Liposarcoma Diagnosed by Thallium-201 Myocardial Single Photon Emission Computed Tomography
Authors: M Oshima, T Kondo, Y Uno
Journal: Clinical Nuclear Medicine (1993)

Cardiac metastasis from myxoid liposarcoma is rare. A case is reported of a patient in whom the metastatic cardiac liposarcoma was confirmed by TI-201 SPECT. A 37-year-old man had surgery on his left hip because of a myxoid liposarcoma of the left thigh. Five years later, myocardial perfusion scintigraphy using a TI-201 SPECT showed a perfusion defect in the inferior and posterior part of the left ventricle. At autopsy, a large tumor involving the greater part of the left ventricle wall was noted. Pathologic findings confirmed the diagnosis of cardiac metastasis from the myxoid liposarcoma.