High-Dosage Vitamin E Supplementation and All-Cause Mortality
Authors: Ishwarlal Jialal, Sridevi Devaraj
Journal: Annals of Internal Medicine (2005)

Letters19 July 2005High-Dosage Vitamin E Supplementation and All-Cause MortalityIshwarlal Jialal, MD, PhD and Sridevi Devaraj, PhDIshwarlal Jialal, MD, PhDFrom the University of California, Davis, Medical Center, Sacramento, CA 95817. and Sridevi Devaraj, PhDFrom the University of California, Davis, Medical Center, Sacramento, CA 95817.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-2-200507190-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest the statistically questionable and selective meta-analysis by Miller and colleagues (1). Because of their arbitrary exclusion criteria, they omitted 2 studies that clearly showed the benefit of combined RRR-α-tocopherol and vitamin C supplementation on the primary end point: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study, which involved 440 hypercholesterolemic patients followed up for 6 years (2), and the Transplant-Associated Arteriosclerosis Study (3).Also, of the 11 studies that Miller and colleagues suggested show harm from high-dose vitamin E supplementation, 5 used vitamin E along with other antioxidants, including β-carotene, which has previously ...References1. Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142:37-46. [PMID: 15537682] LinkGoogle Scholar2. Jialal I, Devaraj S. Antioxidants and atherosclerosis: don't throw out the baby with the bath water [Editorial]. Circulation. 2003;107:926-8. [PMID: 12600900] CrossrefMedlineGoogle Scholar3. Jialal I, Devaraj S. Scientific evidence to support a vitamin E and heart disease health claim: research needs. J Nutr. 2005;135:348-53. [PMID: 15671241] CrossrefMedlineGoogle Scholar4. Singh U, Jialal I. Anti-inflammatory effects of alpha-tocopherol. Ann N Y Acad Sci. 2004;1031:195-203. [PMID: 15753145] CrossrefMedlineGoogle Scholar5. Kris-Etherton PM, Lichtenstein AH, Howard BV, Steinberg D, Witztum JL. Antioxidant vitamin supplements and cardiovascular disease. Circulation. 2004;110:637-41. [PMID: 15289389] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From the University of California, Davis, Medical Center, Sacramento, CA 95817.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMeta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality Edgar R. Miller III , Roberto Pastor-Barriuso , Darshan Dalal , Rudolph A. Riemersma , Lawrence J. Appel , and Eliseo Guallar High-Dosage Vitamin E Supplementation and All-Cause Mortality Thomas Carter High-Dosage Vitamin E Supplementation and All-Cause Mortality Joseph E. Baggott High-Dosage Vitamin E Supplementation and All-Cause Mortality Edgar R. Miller III , Lawrence J. Appel , Eliseo Guallar , and Roberto Pastor-Barriuso Brief Communication: The Prevalence of High Intake of Vitamin E from the Use of Supplements among U.S. Adults Earl S. Ford , Umed A. Ajani , and Ali H. Mokdad An Editorial Update: Annus horribilis for Vitamin E Eliseo Guallar , Daniel F. Hanley , and Edgar R. Miller III High-Dosage Vitamin E Supplementation and All-Cause Mortality David H. Blatt and William A. Pryor High-Dosage Vitamin E Supplementation and All-Cause Mortality Koyamangalath Krishnan , Sharon Campbell , and William L. Stone High-Dosage Vitamin E Supplementation and All-Cause Mortality Harri Hemilä High-Dosage Vitamin E Supplementation and All-Cause Mortality Wee-Shiong Lim , Rajka Liscic , Chengjie Xiong , and John C. Morris High-Dosage Vitamin E Supplementation and All-Cause Mortality Connie Marras , Anthony E. Lang , David Oakes , Michael P. McDermott , Karl Kieburtz , Ira Shoulson , Caroline M. Tanner , and Stanley Fahn High-Dosage Vitamin E Supplementation and All-Cause Mortality Simin Nikbin Meydani , Joseph Lau , Gerard E. Dallal , and Mohsen Meydani High-Dosage Vitamin E Supplementation and All-Cause Mortality Kent J. DeZee , William Shimeall , Kevin Douglas , and Jeffrey L. Jackson High-Dosage Vitamin E Supplementation and All-Cause Mortality Antonio M. Possolo Metrics Cited byVitamin E for the treatment of E-antigen-positive chronic hepatitis B in paediatric patients: results of a randomized phase 2 controlled studyVitamin E for the treatment of children with hepatitis B e antigen-positive chronic hepatitis: A systematic review and meta-analysisPossible role of tocopherols in the modulation of host microRNA with potential antiviral activity in patients with hepatitis B virus-related persistent infection: a systematic reviewAtherogenesis, the oxidative LDL modification hypothesis revisitedAntioxidants in Food: Mere Myth or Magic Medicine?Bioactive Nutritional Supplements for Chronic Kidney Disease: Potential Cost BenefitsNo evidence supports vitamin E indiscriminate supplementationDecision Analysis Supports the Paradigm That Indiscriminate Supplementation of Vitamin E Does More Harm than GoodAntioxidants and Modulation of Cardiovascular DiseaseAdverse effects of vitamin E by induction of drug metabolismCellular, molecular and clinical aspects of vitamin E on atherosclerosis preventionVitamin E Regulatory Mechanisms 19 July 2005Volume 143, Issue 2Page: 155KeywordsCardiovascular diseasesLongitudinal studiesOxidative stressPopulation statisticsProteinsRenal diseasesStatistical dataVitamin CVitamin E ePublished: 19 July 2005 Issue Published: 19 July 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...