tbuckley/cabot-search huggingface dataset:
Stockinette for dermatological dressings
Authors: N. R. Rowell
Journal: British Journal of Dermatology (1980)

Journal Article Stockinette for dermatological dressings Get access N. R. Rowell N. R. Rowell Department of Dermatology, The General Infirmary, Leeds LS1 3EX Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 102, Issue 1, 1 January 1980, Page 117, https://doi.org/10.1111/j.1365-2133.1980.tb05679.x Published: 01 January 1980
AT-1 receptor antagonism modifies the mediation of endothelin-1, thromboxane A2, and catecholamines in the renal constrictor response to angiotensin II
Authors: E.V.A. Cediel, Natalia de las Heras, David Sanz-Rosa, Olga Velasco, Victoria Cachofeiro, Vicente Lahera
Journal: Kidney International (2004)
Pediatric Clinical Chemistry
Authors: Carlos Abramowsky
Journal: JAMA (1985)

For many years the major reference for working in chemistry laboratories that served children's hospitals or pediatric services has been Meite's<i>Pediatric Clinical Chemistry</i>. Notwithstanding the very useful comments interspersed by contributing authors, this book is more properly considered as a manual for consultation on technical procedures and instrumentation than as a textbook. This multiauthored text is a welcome addition to the pediatric clinical laboratory bookshelf, organized into 23 chapters with the usual topics of clinical chemistry texts, including the expected sections on bilirubin, pediatric enzymology, fetal lung maturity, and screening for metabolic diseases. Supporting chapters include an excellent one on specimen collection procedures and laboratory statistics. However, the basics of laboratory techniques, quality control, instrumentation, and management are absent or only alluded to throughout the text, which suggests an informed audience is expected. Chapters are preceded by a section on pathophysiology or biochemistry of an analyte (ie, bilirubin and
Endotoxin Exposure May Modify the Relationship Between Mouse Allergen Exposure and Incident Sensitization to Mouse
Authors: Sharon K. Ahluwalia, Roger Peng, Charles Aloe, Wayne G. Shreffler, Mary Krevans, Karol A. Hagberg, Peter S. Thorne, Elizabeth Matsui
Journal: Journal of Allergy and Clinical Immunology (2013)
Rapidly involuting congenital haemangioma associated with transient thrombocytopenia and coagulopathy: a case series
Authors: E. Baselga, M.R. Cordisco, M. Garzon, M.T. Lee, A. Alomar, F. Blei
Journal: British Journal of Dermatology (2008)

Rapidly involuting congenital haemangioma (RICH) may present with thrombocytopenia, low fibrinogen and elevated fibrin degradation products and D-dimers. Such complications have rarely been reported. We wished to define the clinical characteristics of the thrombocytopenia and coagulopathy associated with RICH, to emphasize the transient nature of this haematological complication and to distinguish these abnormalities from true Kasabach-Merritt phenomenon (KMP). We present a case series of seven patients with large RICH who presented with thrombocytopenia and coagulopathy during the first week of life. Clinical and haematological characteristics were recorded retrospectively. Two of the patients were treated with embolization due to early signs of high-output cardiac failure; four patients received oral corticosteroids in the range of 2 mg kg(-1) daily; one patient did not receive any treatment in the neonatal period, although the tumour was excised at 6 months of age. Two patients with platelet counts lower than 10 x 10(9) L(-1) received a platelet transfusion. There were no bleeding complications and only one patient presented with petechiae. In all seven patients, platelet counts started to increase at > 2 weeks of age and the coagulopathy resolved. We conclude that RICH may present with thrombocytopenia and coagulopathy similar to mild KMP early in the neonatal period. However, in contrast to true KMP, these abnormal laboratory findings are self-limited and are usually not complicated by bleeding problems.
A variant in myeloperoxidase promoter hastens the emergence of hepatocellular carcinoma in patients with HCV-related cirrhosis
Authors: Pierre Nahon, Angela Sutton, Pierre Rufat, Nathalie Charnaux, Abdellah Mansouri, Richard Moreau, Nathalie Ganne-Carrié, Véronique Grando-Lemaire, Gisèle N’Kontchou, Jean-Claude Trinchet, Dominique Pessayre, Michel Beaugrand
Journal: Journal of Hepatology (2011)
Cigarette Smoking and the Risk of Gestational and Pregestational Diabetes in Two Consecutive Pregnancies
Authors: Paul D. Terry, Elisabete Weiderpass, Claes-Göran Östenson, Sven Cnattingius
Journal: Diabetes Care (2003)

Cigarette smoking during pregnancy may increase the risk of gestational diabetes mellitus (GDM) or pregestational diabetes mellitus (PDM). Smoking has been associated positively with hyperinsulinemia and insulin resistance in experimental studies, although the association with diabetes remains unclear. To further explore this issue, we examined the association with smoking in the largest prospective cohort study of GDM and PDM to date.The study population comprised 212190 women in the population-based Swedish Birth Registry who had their first and second deliveries between January 1987 and December 1995. Maternal characteristics were recorded in a standardized manner at the first prenatal visit, followed by a clinical examination and a standardized in-person interview to assess lifestyle habits. Women were categorized as nonsmokers, light smokers (one to nine cigarettes per day), or moderate-to-heavy smokers (at least 10 cigarettes per day).Women with GDM in their first pregnancy experienced an eight- to ninefold increased risk of GDM or PDM in their second pregnancy. Cigarette smoking was not associated with increased risk of these conditions. Neither women who smoked during their first and second pregnancies nor those who commenced smoking between pregnancies had a higher risk of GDM or PDM than nonsmokers.Our findings do not support an association between cigarette smoking and risk of GDM or PDM in young women of childbearing age.
Effects of the isoflavones genistein and equol on the gonadal development of Japanese medaka Oryzias latipes.
Authors: Yiannis Kiparissis, Gordon C Balch, Tracy L Metcalfe, Chris D Metcalfe
Journal: Environmental Health Perspectives (2003)

The estrogenic isoflavone compound genistein recently has been found in the effluents of sewage treatment plants and pulp mills, and the related compound equol has been detected in the runoff from agricultural fields treated with hog manure. Waterborne exposures of Japanese medaka (Oryzias latipes) to equol from soon after hatch to approximately 100 days posthatch induced gonadal intersex (i.e., testis-ova) in males at incidences of 10 and 87% in equol treatments of 0.4 and 0.8 micro g/L, respectively. Exposure to the highest test concentration of genistein, 1,000 micro g/L, also caused a low incidence (i.e., 12%) of gonadal intersex in male medaka. The ovaries of female medaka from both equol and genistein treatments showed delayed oocyte maturation, atretic oocytes, an enlarged ovarian lumen, proliferation of somatic stromal tissue, and primordial germ cells; responses were concentration dependent. Alterations to externally visible secondary sex characteristics occurred in medaka exposed to both equol and genistein. In treatments with 1,000 micro g/L genistein, 72% of male medaka (as identified by the gonadal phenotype) showed feminized secondary sex characteristics. Gonadal intersex and alterations to secondary sex characteristics have been noted in several fish populations around the world. This laboratory study indicates that isoflavone compounds should be considered candidate estrogenic compounds that may be involved in the alteration of sexual development in feral fish populations.
Increased serum levels of soluble vascular cell adhesion molecule-1 and soluble E-selectin in patients with polymyositis/dermatomyositis
Authors: M. Kubo, H. Ihn, K. Yamane, N. Yazawa, K. Kikuchi, Y. Soma, K. Tamaki
Journal: British Journal of Dermatology (2000)

Elevated levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin) have previously been reported in patients with various inflammatory diseases, but not in patients with polymyositis/dermatomyositis (PM/DM).To determine serum levels and significance of sVCAM-1 and sE-selectin in patients with PM/DM.Serum samples from 36 PM/DM patients, 30 patients with systemic sclerosis and 25 healthy control subjects were examined using specific enzyme-linked immunosorbent assay systems.The serum levels of sVCAM-1 in the PM/DM patients were significantly higher than those in the healthy controls. The elevated serum sVCAM-1 levels were correlated with the values of elevated erythrocyte sedimentation rate and elevated serum hyaluronate levels in the PM/DM patients. The serum sE-selectin levels in the PM/DM patients were also significantly higher than those in the healthy controls. The elevated serum sE-selectin levels were correlated with the incidence of elevated creatine kinase activities. The concentrations of serum sE-selectin were correlated with the serum tissue inhibitor of metalloproteinase-1 concentrations in the PM/DM patients (r = 0.53).These results suggest that serum sVCAM-1 and sE-selectin levels might be useful for detecting disease activity in patients with PM/DM.
Acute Deficiency of Thyroxine-Binding Globulin during L-Asparaginase Therapy
Authors: Marc B. Garnick, P. Reed Larsen
Journal: New England Journal of Medicine (1979)

ESCHERICHIA COLI L-asparaginase, an antileukemic agent, acts by hydrolyzing plasma L-asparagine to L-aspartic acid and ammonia, resulting in depletion of plasma L-asparagine levels.1 , 2 Cells susc...
Rescuing the NIH before it is too late
Authors: A. R. Marks
Journal: Journal of Clinical Investigation (2006)

In the Coen brothers' The Big Lebowski the hero, who calls himself "The Dude," has just had his apartment broken into by some dumb thugs. One of the thugs lifts the Dude's prized bowling ball and says, "What . . . is this?" The Dude replies, "Obviously you are not a golfer." The current state of the NIH prompts me to say to its director, Dr. Elias Zerhouni, "Obviously you are not a scientist."
Are 200,000 Doctors Wrong?
Authors: Donovan F. Ward
Journal: JAMA (1965)

Are 200,000 doctors<i>wrong?</i>I put the question first to the members of this House: Is it possible for an entire profession of dedicated men and women—engaged in all the arts, the sciences, and the practices of merciful healing—to be so nearly of one mind about a matter affecting human health, and at the same time to be<i>wrong?</i> Is it possible, my colleagues in medicine, for us to go forth every day among 190 million Americans, to be with them in our offices, in their homes, in hospitals and clinics, to be with them at birth and death and the most critical moments of their lives— is it possible for<i>all</i>of us to be so close to<i>all</i>of them<i>all</i>the time in<i>all</i>these places—and still be<i>wrong?</i> My answer—and do not be shocked—is<i>yes</i>, we have been wrong! Oh, no,<i>not</i>wrong in our assessment
Do selective serotonin reuptake inhibitors cause suicide?: Data seem to be incorrect
Authors: Alex J Mitchell
Journal: BMJ (2005)

Do selective serotonin reuptake inhibitors cause suicide? Risk of suicide should be assessed for whole class of antidepressantsEditor-Gunnell et al's report on suicide risk with selective serotonin reuptake inhibitors (SSRIs) raises several issues. 1 Firstly, clinicians have observed that the first weeks of treatment of severe depression with an antidepressant are accompanied by a higher risk of suicide because of a drug induced motor disinhibition that is not yet accompanied by mood improvement. 2 Secondly, the authors' finding of a trend towards a protective effect of SSRIs against suicidal thoughts (odds ratio 0.77) compared with a trend towards an increased risk of self harm (odds ratio 1.57) is paradoxical.More surprising is the heterogeneity of results among SSRIs.Why would sertraline show a protective effect for suicidal thoughts and simultaneously increase the risk of self harm?The risk difference between citalopram and its active S-enantiomere, escitalopram, is also strange.No strong biological rationale can explain such heterogeneity among drugs with the same mechanism of action.Thirdly, the authors mention that the Medicine and Healthcare products Regulatory Agency found little evidence for a risk difference between SSRIs and the other antidepressants.The two accompanying papers show that the suicidal risk seems similar for serotoninergic and tricyclic antidepressants. 3 4The risk of suicide must be assessed for the whole class of antidepressants.The next stage would be to measure the risk of suicide according to the time since starting an antidepressant.Initially, the risks are higher than the benefits.To confirm old clinical observations by evidence based methods would be interesting and useful.
Should Planning Agencies Allocate Managers Instead of Beds?
Authors: Charles R. Buck
Journal: New England Journal of Medicine (1978)

Under Public Law 93–641 state and local planning agencies make decisions regarding allocation of hospital resources. Hospital managers propose that their hospitals renovate or expand beds and install expensive equipment. The planning agencies respond to these proposals. Thus, using hospital beds as an example, planners allocate hospital beds to hospital managers. What if the opposite were true, and planners had the authority to allocate managers to hospitals — beds and all? Said another way, what if the hospital managers who were responsible for high-quality, efficient, highly occupied hospitals were given (by the planners) the responsibility for managing under-utilized, ineffective hospitals? . . .
Public Health Implications of Antiretroviral Therapy and HIV Drug Resistance
Authors: Mark A. Wainberg
Journal: JAMA (1998)

Widespread use of antiretroviral agents and increasing occurrence of human immunodeficiency virus (HIV) strains resistant to these drugs have given rise to a number of important issues. Some of these concerns are distinct from the obvious question of the relationship between drug resistance and treatment failure and have potentially widespread public health implications. The relevant issues include but are not limited to the following:(1) frequency with which drug-resistant virus may be transmitted via sexual, intravenous, or mother-to-child routes; (2) ability of drug-resistant variants to be transmitted, a question that relates, in part, to the relative fitness of such strains; (3) effectiveness of antiviral therapy in diminishing viral burden in both blood and genital secretions, and whether this may be compromised in persons harboring resistant virus; and (4) importance of patient adherence to antiviral therapy and its relationship to sustained reduction in viral load to minimize the appearance in and transmission of drug-resistant virus from both blood and genital secretions. Thus, prevention of both development of HIV drug resistance as well as transmission of drug-resistant variants is a central issue of public health importance. Unless this topic is appropriately addressed, the likelihood is that drug-resistant variants of HIV, if able to successfully replicate, will sustain the epidemic and limit the effectiveness of antiviral therapy.
THE IMPORTANCE OP POSITION IN EXAMINATION OF DISEASES OF THE HEART.
Authors: O. B. CAMPBELL
Journal: JAMA (1892)

The heart (the only organ in the body which is never at rest) with its investing membranes, the serous and fibrous pericardium, is situated in the median line of the thorax, and occupies the entire space between the two lungs and pleurÆ. This pericardial sac includes the heart, the origin of the large blood vessels, and possesses very complete fixation. Next to the pelvis Paul claims the pericardial sac to be the least movable region in the human body. Its apex is fixed to the skeleton by three ligaments, one coalescing with the inter vertebral ligament of the third cervical vertebra; another uniting with the middle aponeurosis of the neck is inserted into the hyoid bone, the other passes anteriorly to the sternum. The base of the pericardium is fixed to the centre of the diaphragm and through the medium of this muscle is united posteriorly to the spinal column,
Germany tightens law on stem cell treatments
Authors: N. Stafford
Journal: BMJ (2009)

Treatments in Germany involving adult stem cells will be more closely regulated after revision of Germany’s medical products law received final approval by the Bundesrat, the upper house of parliament.

The Bundesrat approved the revisions on 10 July, just over two weeks after the German Society for Neurology and the German Parkinson Society issued a joint statement warning that patients with Parkinson’s disease should not undergo treatments involving bone marrow stem cells. Such treatments are being offered around the world, including at the XCell-Center in Cologne, the societies said in the statement on 23 June.

The XCell-Center began operating in Cologne in January 2007, since when “more than 1600 patients have safely undergone our various stem cell treatments,” the centre’s website states. 

The website (www.xcell-center.com), available in 10 languages, gives a detailed overview …
Genes and Uterine Fibroids
Authors: Brian Vastag
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 4410: Neutralizing Endosialin antibody, MORAb-004, enhances efficacy of TAXOTERE in a metastatic melanoma model
Authors: Candice Krauthauser, Luigi Grasso, Nicholas Nicolaides, JianMin Lin
Journal: Cancer Research (2012)

Abstract Endosialin/Tumor Endothelial Marker-1 (TEM1) is a cell surface glycoprotein that is expressed on cells involved in the development of tumor vasculature, primarily pericytes and stromal fibroblasts. Studies have found it to play a key role in tumor growth and neo-vessel formation in numerous cancer types. We are currently evaluating the safety and therapeutic potential of MORAb-004, a humanized monoclonal IgG targeting endosialin/TEM-1, in clinical trials. Because MORAb-004 only recognizes human antigen and has no cross-reactivity with rodent endosialin/TEM-1, we generated a human endosialin/TEM-1 knock-in mouse in order to assess its activity in vivo. Previously, in this transgenic model, we found that MORAb-004 significantly inhibited subcutaneous B16-F10 melanoma progression by ∼70% when administered intravenously for 5 consecutive days. Moreover, using the Lewis Lung Carcinoma model of metastatic disease our results showed that MORAb-004 had a significant inhibitory effect on the number of lung metastases. For these studies, supporting clinical trials for using MORAb-004 in combination with standard of care chemotherapeutics, we developed a B16-F10 melanoma lung colonization model. In this model, the human endosialin/TEM-1 knock-in mice were implanted intravenously with B16F10 cells adapted for in vivo lung colonization. These mice were treated with Docetaxel, MORAb-004, or the combination of the two agents, respectively. A group of the tumor-bearing mice receiving PBS served as control. At the end of the study, the lungs of each mouse were harvested. A ratio of the area of tumor nodules versus total lung surface area is calculated as tumor burden. MORAb-004, at 50 mg/kg three times weekly for a total of 7 i.v. injections reduced tumor burden by 45%. Treatment of Docetaxel, at 3mg/kg twice weekly for a total of 5 i.p. injections, reduced less than 20% of tumor burden in the lungs. When MORAb004 was added to Docetaxel treatment, a significant enhancement of efficacy was observed. The reduction of tumor nodules in the lungs was increased to approximately 70%. A similar trend is seen in combination therapy where MORAb-004 was added to gemcitabine regimen. Our results demonstrate the ability of MORAb-004 to inhibit tumor growth in a murine model. Moreover, when added to the chemotherapeutic regimen, it significantly enhances the therapeutic effect of traditional chemotherapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4410. doi:1538-7445.AM2012-4410
Ptosis, Erythema, and Rapidly Decreasing Vision
Authors: Adam Zanation, David Fleischman, Sai H. Chavala
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increase of Diabetes.
Authors: James A. Hopkins
Journal: JAMA (1897)

Milton, Del., Aug. 12, 1897. <h3>To the Editor:</h3> —In theJournalof Aug. 7, 1897, I notice a communication from Dr. Ball of Philadelphia, Pa., calling the attention of the profession to the alarming increase of that dread and fatal disease,<i>diabetes</i>. One of his reasons assigned was the increased population of Jews in this country, and, he says, that the presentation of patients with that class of diseases to the hospitals far outnumbers that of any other nationality. His observation is without a doubt correct, but in this part of our country, where there is no other nationality except the native born, I find the same thing among us. So you see, that it is not confined to the Jews alone, but the gentile world as well. There is a cause for this. What may affect the Jews in their country and cause such troubles may not be a
Nebulized solvent ablation of aligned PLLA fibers for the study of neurite response to anisotropic-to-isotropic fiber/film transition (AFFT) boundaries in astrocyte–neuron co-cultures
Authors: Jonathan M. Zuidema, Gregory P. Desmond, Christopher J. Rivet, Kathryn R. Kearns, Deanna M. Thompson, Ryan J. Gilbert
Journal: Biomaterials (2015)