tbuckley/cabot-search huggingface dataset:
Abstract 1895: Genetic polymorphisms of an innate immune gene, <i>Toll-Like Receptor 4</i>, and aggressive prostate cancer risk: A systematic review and meta-analysis
Authors: Yi-Ling Huang, John H. Page, Jen-Hau Chen, Yen-Ling Lin, Jianfeng Xu, Stella Koutros, Sonja Berndt, Stephen J. Chanock, John S. Witte, Yen-Ching Chen
Journal: Cancer Research (2011)

Abstract Toll-like receptor 4 (TLR4) is located on the surface of macrophages and is important for the immune response to several pathogens. Chronic inflammation has been implicated in the pathogenesis of prostate cancer (PCa), and genetic polymorphisms of the innate immune gene TLR4 have been related to the risk of PCa. Six studies have explored the association between TLR4 polymorphisms and the risk of PCa. Five studies mainly included men of European ancestry. We conducted a systematic review of all genetic association studies that evaluated the relationship between TLR4 genotypes and aggressive PCa risk. We found the rs11536889 variant was significantly associated with an increased risk of aggressive PCa under a dominant genetic model [odds ratio (OR) = 1.20, 95% CI = 1.05-1.37]. However, rs1927914, rs2149356, or rs10759932 polymorphisms were not associated with the risk of PCa under any inheritance mode. In conclusion, this study found that the polymorphism TLR4 rs11536889 was significantly associated with the risk of aggressive PCa. Additional large-scale genetic association studies are needed to confirm these findings. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1895. doi:10.1158/1538-7445.AM2011-1895
Pityriasis rubra pilaris and HIV infection
Authors: Andrew Blauvelt, George T. Nahass, Rube J. Pardo, Francisco A. Kerdel
Journal: Journal of the American Academy of Dermatology (1991)

Many cutaneous diseases have been reported in patients with human immunodeficiency virus infection. We report two patients with pityriasis rubra pilaris and human immunodeficiency virus infection. In one patient, the onset of pityriasis rubra pilaris preceded the discovery of human immunodeficiency virus infection. In the second patient, the onset of pityriasis rubra pilaris occurred shortly after the patient tested positive for human immunodeficiency virus infection. Both patients had a severe form of pityriasis rubra pilaris, and both had a minimal therapeutic response to etretinate.
Local recurrence in melanoma in situ: influence of sex, age, site of involvement and therapeutic modalities
Authors: I. Zalaudek, M. Horn, E. Richtig, S. HOdl, H. Kerl, J. Smolle
Journal: British Journal of Dermatology (2003)

Melanoma in situ (MIS) occurs on various body sites, in various age groups, and is managed by a variety of treatment modalities. Despite early treatment, recurrences may be encountered.To evaluate the influence of sex, age, body site and treatment modalities on recurrence rate in MIS. Methods Histologically confirmed cases of MIS from our dermatopathological database (n = 1351) from 1990 to 2000 were statistically analysed with respect to epidemiological characteristics, treatment modalities and outcome. Treatment modalities of the included MIS were evaluated by searching for data in the medical records and histopathological data sheets.There was a predominance of female patients (60.8%), and of involvement of the head and neck (53.4%). Total excision was performed in 95.9% of all patients; the remainder received cryotherapy, laser therapy or radiotherapy. In 265 patients, no data on definitive treatment were available. Alternatives to total excision were particularly performed in patients with advanced age and with lesions localized on the face. The mean +/- SD 5-year recurrence rate was 6.8 +/- 1.3% for surgically removed lesions, but was 31.3 +/- 8.5% for lesions treated by other modalities (log rank test: P < 0.0001). In a multivariate approach, mode of therapy and site of involvement, but not age, were significant prognostic variables (Cox proportional hazard model: P < 0.01).In MIS, treatment modalities other than surgical excision may be used in certain situations, but carry a significantly increased risk of local recurrence.
Abstract LB-101: Quantitative imaging of protein expression using multiplex quantum dot immunohistochemistry
Authors: Lee A.D. Cooper, Rami Yacoub, David A. Gutman, Fusheng Wang, Carlos S. Moreno, Daniel J. Brat, Roberd M. Bostick, Joel H. Saltz
Journal: Cancer Research (2012)

Abstract Introduction: Immunohistochemistry (IHC) is an important tool for studying protein expression in the tumor microenvironment. Advances in imaging hardware now permit an entire slide to be digitized at high magnification so that software can analyze protein expression within individual cells across the entire tissue section. The chromaphores and organic fluorescent probes used in traditional IHC limit the utility of quantitative IHC, since only relatively few proteins can be measured simultaneously. A new class of fluorescent labels made of semiconductor nanocrystals, known as quantum dots (QD) has unique optical properties that have the potential to overcome limitations of traditional IHC techniques and expand the usefulness of quantitative image analysis approaches. The narrowband emission spectra of these novel probes enable them to be highly multiplexed without significant spectral overlap, providing independent measurements of protein expression with minimal crosstalk. Methods: We have developed a collection of software algorithms around the QD-IHC protocol to analyze protein expression, co-expression, and subcellular localization in whole-slide QD-IHC images. This system segments the digitized tissue into individual cells, their subcellular compartments and multicellular structures to generate comprehensive digital descriptions. Features are calculated for each cell to represent the morphology, protein expression, co-expression, and subcellular localization. Each cell is mapped to their closest multicellular structure, enabling protein expression features to be analyzed as a function of distance to vessels, necrosis, etc. We evaluated the use of QD-IHC for analysis of formalin-fixed, paraffin-embedded glioblastoma tissues against known pathways using streptavidin-biotin detection and applied our software system to analyze expression and co-expression patterns. Features of protein expression were calculated for individual cells along with distance-to-vessel measurements. Results: A five-plex staining was achieved and sections were stained and digitized on a whole-slide scanner (Pannoramic from 3D Histech). The digitized tissues were analyzed using our software system to generate measurements of protein expression in millions of cells. These measurements were used to generate visualizations, including analyses of the variations of expression with respect to distance-to-nearest-vessel. We are continuing to enhance our software capabilities to include statistical tests and updated imaging and analysis capabilities will be presented. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-101. doi:1538-7445.AM2012-LB-101
Twenty four hour care in inner cities
Authors: E L Brown
Journal: BMJ (1989)

during the first vear.TFhe ouitpatient waiting time stands at two weeks, and sincc it opened the waiting time at the longer established unit has declined steadilI to an average of three months.We believe that providing adequate facilities of this type is a much more satisfactory solution to the problem of delays in fitting hearing aids than the proposal suggested in the Royal National Institute for the Deaf document entitled Hearing Aids -The Case for Change.
The Frequency and Clinical Manifestations of Intestinal Worms
Authors: PAUL F. WHITAKER
Journal: Annals of Internal Medicine (1931)

Article1 March 1931The Frequency and Clinical Manifestations of Intestinal WormsPAUL F. WHITAKER, M.D., F.A.C.P.PAUL F. WHITAKER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-4-9-1212 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a former article the writer reported a series of five hundred stool examinations on consecutive patients presenting themselves for study. Since that time a routine stool examination has been continued, and the present paper embraces a series of 1650 cases. This work has been done to determine in a measure the frequency of intestinal parasitic infection in Eastern North Carolina. Some years back the subject was much before the profession, due to the work of the Rockefeller Foundation and enormous good was accomplished through this splendid work, particularly in discovering and treating hook worm infections. At that time one...Bibliography1 OSLER-MCCRAE : Practice of medicine, 9th Edition. Google Scholar2 GREENS : Medical Diagnosis, 8th Edition. Google Scholar3 FRENCH : Differential Diagnosis, 8th Edition. Google Scholar4 MAYO WJ, M.D.: The Enlarged Spleen. Southern Medical Journal, January, 1928. CrossrefGoogle Scholar5 LAWSON P MINOT AS ROBINS BH, M.D., , PHG., , M.S., Nashville, Tenn.: The Prevention and Treatment of Carbon Tetrochloride Intoxication. J. A. M. A., February 4, 1928. MedlineGoogle Scholar6 NEALROBNETT PMD, Columbia, Mo.: Proper Use and Interpretation of Leukocyte Count. Southern Medical Journal, September, 1927. CrossrefGoogle Scholar7 HEWLETT : Pathologic Physiology of Internal Disease. Google Scholar8 WHITAKER PF, M.D.: Intestinal Parasites, Their Frequency and Clinical Manifestation. Southern Medicine and Surgery, August, 1928. Read by invitation before the 1930 meeting of the North Carolina State Medical Society at Pinehurst, N. C., April 29th, 1930. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL F. WHITAKER, M.D., F.A.C.P.Affiliations: Kinston, N. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1931Volume 4, Issue 9Page: 1212-1216KeywordsHookwormsParasitic diseases ePublished: 1 December 2008 Issue Published: 1 March 1931 PDF downloadLoading ...
Human Formyl Peptide Receptor 2 Senses Highly Pathogenic Staphylococcus aureus
Authors: Dorothee Kretschmer, Anne-Kathrin Gleske, Maren Rautenberg, Rong Wang, Martin Köberle, Erwin Bohn, Torsten Schöneberg, Marie-Joséphe Rabiet, Francois Boulay, Seymour J. Klebanoff, Kok A. van Kessel, Jos A. van Strijp, Michael Otto, Andreas Peschel
Journal: Cell Host & Microbe (2010)
THE EFFECT OF ACUTE ARTERIOVENOUS FISTULA ON RENAL FUNCTIONS 1
Authors: James G. Hilton, Donald M. Kanter, David R. Hays, Edward H. Bowen, James R. Golub, John H. Keating, René Wégria
Journal: Journal of Clinical Investigation (1955)

was determined from the analysis of arterial and mixed venous bloods. The arterial blood was obtained from the right brachial artery. The mixed venous blood was withdrawn from the right ventricle through a catheter introduced via the right jugular vein into the right ventricle under fluoroscopic control. Glass cannulae were tied in the central end of the right common carotid artery and the central end of the right femoral vein; these two cannulae were connected by a rubber or polyvinyl tube previously filled with isotonic sodium chloride solution and closed by a screw clamp. A similar communication was established between the central end of the right femoral artery and the central end of the left femoral vein. In 5 of the 10 experiments, a catheter connected to a water manometer was introduced via the left femoral vein into the inferior vena cava up to the level of the renal veins in order to measure the changes in venous pressure at this site. Before being anesthetized, the animals were given orally 0.14 to 0.29 grams of sodium chloride per kilogram of weight to insure adequate urinary excretion of sodium and chloride during the experiment. While the operative procedures were being carried out, priming doses of 1.5 grams of creatinine and 0.07 grams of sodium para-amino
Proapoptotic Peptide-Mediated Cancer Therapy Targeted to Cell Surface p32
Authors: Lilach Agemy, Venkata R Kotamraju, Dinorah Friedmann-Morvinski, Shweta Sharma, Kazuki N Sugahara, Erkki Ruoslahti
Journal: Molecular Therapy (2013)

Antiangiogenic therapy is a promising new treatment modality for cancer, but it generally produces only transient tumor regression. We have previously devised a tumor-targeted nanosystem, in which a pentapeptide, CGKRK, delivers a proapoptotic peptide into the mitochondria of tumor blood vessel endothelial cells and tumor cells. The treatment was highly effective in glioblastoma mouse models completely refractory to other antiangiogenic treatments. Here, we identify p32/gC1qR/HABP, a mitochondrial protein that is also expressed at the cell surface of activated (angiogenic) endothelial cells and tumor cells, as a receptor for the CGKRK peptide. The results demonstrate the ability of p32 to cause internalization of a payload bound to p32 into the cytoplasm. We also show that nardilysin, a protease capable of cleaving CGKRK, plays a role in the internalization of a p32-bound payload. As p32 is overexpressed and surface displayed in breast cancers, we studied the efficacy of the nanosystem in this cancer. We show highly significant treatment results in an orthotopic model of breast cancer. The specificity of cell surface p32 for tumor-associated cells, its ability to carry payloads to mitochondria, and the efficacy of the system in important types of cancer make the nanosystem a promising candidate for further development.
Olfactory Stimulation Selectively Modulates the OFF Pathway in the Retina of Zebrafish
Authors: Federico Esposti, Jamie Johnston, Juliana M. Rosa, Kin-Mei Leung, Leon Lagnado
Journal: Neuron (2013)

Cross-modal regulation of visual performance by olfactory stimuli begins in the retina, where dopaminergic interneurons receive projections from the olfactory bulb. However, we do not understand how olfactory stimuli alter the processing of visual signals within the retina. We investigated this question by in vivo imaging activity in transgenic zebrafish expressing SyGCaMP2 in bipolar cell terminals and GCaMP3.5 in ganglion cells. The food-related amino acid methionine reduced the gain and increased sensitivity of responses to luminance and contrast transmitted through OFF bipolar cells but not ON. The effects of olfactory stimulus were blocked by inhibiting dopamine uptake and release. Activation of dopamine receptors increased the gain of synaptic transmission in vivo and potentiated synaptic calcium currents in isolated bipolar cells. These results indicate that olfactory stimuli alter the sensitivity of the retina through the dopaminergic regulation of presynaptic calcium channels that control the gain of synaptic transmission through OFF bipolar cells.
CESSATION OF LOCALIZED EPILEPTIC CONVULSIONS IN INOPERABLE CASES AFTER PUNCTURE OF THE LATERAL VENTRICLES
Authors: Alfred Gordon
Journal: JAMA (1930)

In a previous communication,<sup>1</sup>reference was made to persistent epileptic convulsions in a case of hydrocephalus which disappeared after the withdrawal of small amounts of cerebrospinal fluid from the lateral ventricles. In the present contribution, another instance is described in which the same procedure was followed by excellent results during four whole years after the last attack. The object of placing it on record is to emphasize again the already expressed opinion that, while the reception of stimuli and the discharge of muscular spasms in epilepsy are the province of the motor cells in the cortex, nevertheless the original sources of stimulation present a large field of localizations in the brain between its anterior and posterior poles and the site of the lesion may not necessarily be in the motor area itself. The case reported here has its especial value from this particular point of view; also on therapeutic
Oncogenes, Trousseau Syndrome, and Cancer-Related Changes in the Coagulome of Mice and Humans
Authors: Janusz Rak, Joanne L. Yu, James Luyendyk, Nigel Mackman
Journal: Cancer Research (2006)

Abstract Cancer is often associated with venous thrombosis, a phenomenon that was first described by Trousseau in 1865 (Trousseau syndrome). Recent studies have begun to explain how oncogenic events may deregulate the hemostatic system. For instance, activated oncogenes (K-ras, EGFR, PML-RARα, and MET) or inactivated tumor suppressors (e.g., 53 or PTEN) may increase the risk of thrombosis by inducing the expression of tissue factor, a potent procoagulant molecule, and plasminogen activator inhibitor-1, a fibrinolysis inhibitor. In a more complex clinical reality, transforming genes may often act in concert with numerous epigenetic factors, including hypoxia, inflammation, anticancer therapy, contact between blood and metastatic cancer cells, and emission of procoagulant vesicles from tumors and their stroma into the circulation. To add to mechanistic insights gained from mouse models, which may not fully phenocopy human Trousseau syndrome, we suggest that valuable clues to progression and thrombosis risk may be obtained by monitoring multiple hemostatic variables in cancer patients (“coagulomics”). (Cancer Res 2006; 66(22): 10643-6)
Trial of Hexylresorcinol as Air Disinfectant for Prevention of Colds in Office Workers
Authors: O. M. Lidwell, R. E. O. Williams
Journal: BMJ (1954)

A marked antagonistic effect of the vitamin K, on the hypoprothrombinaemia caused by these drugs is shown.Patients with low prothrombin activities, when given vitamin K, emulsion, showed modification of the pro- thrombin level while maintained on regular dosage of either ethyl biscoumacetate or phenylindanedione.The application of these effects to the management of anticoagulant therapy is discussed.It is emphasized that small doses of vitamin Ki of the order, of 10-15 mg., when used in this particular form, should normally be employed if states which are refractory to the action of these anticoagulant drugs are to be avoided.The fact that vitamin K1 is nnw generally available makes it safer to use dicoumarol-gxroup drugs or phenyl- indanedione in obtaining therapeutic levels of hypoprothrombinaemia.Thanks are due to those students and members of the Medical School staff who volunteered as subjects for the experi- ments, and to Roche Products Ltd. for supplies of the vitamin K1 solution used.
Neural correlates of learning in an electrocorticographic motor-imagery brain-computer interface
Authors: Tim M. Blakely, Jared D. Olson, Kai J. Miller, Rajesh P. N. Rao, Jeffrey G. Ojemann
Journal: Brain-Computer Interfaces (2014)

Human subjects can learn to control a one-dimensional electrocorticographic (ECoG) brain-computer interface (BCI) using modulation of primary motor (M1) high-gamma activity (signal power in the 75–200 Hz range). However, the stability and dynamics of the signals over the course of new BCI skill acquisition have not been investigated. In this study, we report three characteristic periods in evolution of the high-gamma control signal during BCI training: initial, low task accuracy with corresponding low power modulation in the gamma spectrum, followed by a second period of improved task accuracy with increasing average power separation between activity and rest, and a final period of high task accuracy with stable (or decreasing) power separation and decreasing trial-to-trial variance. These findings may have implications in the design and implementation of BCI control algorithms.
Case 41-1977
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Frank C. Wheelock, Jaime Prat
Journal: New England Journal of Medicine (1977)

Presentation of CaseA 68-year-old man was admitted to the hospital because of dehydration.There was a long history of peripheral vascular disease. Fifteen years before entry bleeding occurred from a peptic ulcer. Eight years later a right nephrectomy was performed at another hospital because of a perinephric abscess. Six years before admission ischemic ulcers appeared on the right foot. He was admitted to this hospital, where aortoiliac occlusion was found, and a Dacron aortofemoral bypass graft was inserted. Two months later, becase of persistent pain and ischemic ulcers on the right foot, a right-saphenous-vein femoral-popliteal bypass graft was performed. . . .
Natulan in Management of Late Hodgkin's Disease, Other Lymphoreticular Neoplasms, and Malignant Melanoma
Authors: I. D. H. Todd
Journal: BMJ (1965)

cases; Brill-Symmers disease, 1 case; reticulum-cell sarcoma, 1 case ; melanomatosis, 6 cases; and carcinomatosis (primary unknown), 1 case.
Sleeplessness And Hallucinations
Authors: Barbara Herjanic
Journal: JAMA (1966)

<h3>To the Editor:—</h3> In recent years studies of sleep deprivation have described numerous transient hallucinatory experiences and brief psychotic episodes following many hours of sleeplessness (<i>Arch Gen Psychiat</i><b>15:</b>29, 1966, etc). A recent case of an adolescent whose sleep deprivation was related to a prolonged "celebration" and resulted in a frightening hallucinatory experience which brought him to the mental hospital raises the question of the frequency of this phenomenon in clinical practice. A 19-year-old laborer stated that he had only 2, 2 1/2, 3, and 4 hours of sleep on the four nights prior to hospitalization, with no daytime sleep. When not working during the four days, he spent his time driving around the countryside with friends. During this period he was not drinking excessively. About 9:30 PM on the night of admission he took his girl friend to the cemetery to visit her father's grave. As he was walking
Primary Care Commentary: I Can Take Off My Shoes, Too
Authors: Gabriel Smilkstein
Journal: JAMA (1979)

At a faculty research seminar, we were discussing future directions in family medicine and included the subject of auxiliary health workers, family nurse practitioners, and physicians' assistants. To establish a focus for our discussion, one faculty member said, "We are talking about the barefoot doctor type, the individuals who will be at the front lines of health care provision." In response, John Hilditch, MD, of the University of Toronto, said, "You know, I can take off my shoes, too!" Although this statement was simple, it was also profound. The statement implies that it is appropriate for physicians to be at the front lines of health care provision and, when possible, to offer their patients a full range of health services. I concur. Physicians should not be locked into offering their patients only advanced treatments, leaving less complicated procedures for others. I believe that physicians who commit themselves to the management
INCIDENCE OF STROKE IN PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT USING EDWARDS SAPIEN VALVE FOR CRITICAL AORTIC STENOSIS. META–ANALYSIS COMPARING TRANSFEMORAL VERSUS TRANSAPICAL APPROACH
Authors: Conrad Macon, Abhijit Ghatak, Leonardo Tamariz, Apurva Badheka, Brian O'Neill, Pedro Martinez–Clark, Carlos Alfonso, Mauricio Cohen, William O'Neill, Eduardo De Marchena
Journal: Journal of the American College of Cardiology (2013)