A Spectrum of Myopathy Associated with Alcoholism
Authors: GEORGE KLINKERFUSS
Journal: Annals of Internal Medicine (1967)

Article1 September 1967A Spectrum of Myopathy Associated with AlcoholismII. Light and Electron Microscopic ObservationsGEORGE KLINKERFUSS, M.D., VIRGIL BLEISCH, M.D., MARCONI M. DIOSO, M.D., GERALD T. PERKOFF, M.D., F.A.C.P.GEORGE KLINKERFUSS, M.D.Search for more papers by this author, VIRGIL BLEISCH, M.D.Search for more papers by this author, MARCONI M. DIOSO, M.D.Search for more papers by this author, GERALD T. PERKOFF, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-3-493 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe occurrence of several types of acute muscular abnormalities in chronic alcoholism, first reported by Hed, Larson, and Wahlgren (1), now is well-known (2-6). Ekbom, Hed, Kirstein, and Astrom (3) and Serratrice, Toga, and Roux (4) have described the clinical and histologic features of a more chronic myopathy in patients with severe alcoholism. However, with the exception of extensive studies of a single patient reported by Douglas, Fewings, Casley-Smith, and West (6), information concerning the ultrastructural features of the skeletal muscle abnormalities associated with alcoholism is lacking.In the preceding paper (7) we described the clinical and laboratory abnormalities found...References1. HEDLARSONWAHLGREN RHF: Acute myoglobinuria in alcoholism. Acta Med. Scand. 152: 459, 1955. CrossrefMedlineGoogle Scholar2. HEDLUNDMARKFAHLGRENORELL RCHS: Acute muscular syndrome in chronic alcoholism. Acta Med. Scand. 171: 585, 1962. CrossrefMedlineGoogle Scholar3. EKBOMHEDKIRSTEINASTROM KRLK: Muscular affections in chronic alcoholism. Arch. Neurol. (Chicago) 10: 449, 1964. CrossrefMedlineGoogle Scholar4. SERRATRICETOGAROUX GMH: Chronic proximal syndromes of alcoholic etiology. (With respect to 14 cases.) [Fr.] Presse Med. 74: 1721, 1966. MedlineGoogle Scholar5. PERKOFFHARDYVELEZ-GARCIA GTPE: Reversible acute muscular syndrome in chronic alcoholism. New Eng. J. Med. 274: 1277, 1966. CrossrefMedlineGoogle Scholar6. DOUGLASFEWINGSCASLEY-SMITHWEST RJJR: Recurrent rhabdomyolysis precipitated by alcohol: a case report with physiological and electron microscopic studies of skeletal muscle. Aust. Ann. Med. 15: 251, 1966. MedlineGoogle Scholar7. PERKOFFDIOSOBLEISCHKLINKERFUSS GTMMVG: A spectrum of myopathy associated with alcoholism. I. Clinical and laboratory features. Ann. Intern. Med. 67: 481, 1967. LinkGoogle Scholar8. ADAMSDENNY-BROWNPEARSON RDDCM: Diseases of Muscle. A Study in Pathology. Hoeber Medical Division, Harper & Row, Inc., New York, 1962. Google Scholar9. SHYGONATAS GMNK: Human myopathy with giant abnormal mitochondria. Science 145: 493, 1964. CrossrefMedlineGoogle Scholar10. LUFTIKKOSPALMIERIERNSTERAFZELIUS RDGLB: A case of severe hypermetabolism of nonthyroid origin with a defect in the maintenance of mitochondrial respiratory control: a correlated clinical, biochemical, and morphological study. J. Clin. Invest. 41: 1776, 1962. CrossrefMedlineGoogle Scholar11. HIBBSFERRANSBLACKWEILBAECHERWALSHBURCH RGVJWCDGJJGE: Alcoholic cardiomyopathy; an electron microscopic study. Amer. Heart J. 69: 766, 1965. CrossrefMedlineGoogle Scholar12. SHY GM: Chemical and morphological abnormalities in muscle disease. Ann. N. Y. Acad. Sci. 138: 232, 1966. CrossrefMedlineGoogle Scholar13. DESSOUKYHIBBS DARC: An electron microscopic study of the development of the somatic muscle of the chick embryo. Amer. J. Anat. 116: 523, 1965. CrossrefMedlineGoogle Scholar14. PRICEHOWESBLUMBERG HMELJM: Ultrastructural alterations in skeletal muscle fibers injured by cold. II. Cells of the sarcolemmal tube: observations on "discontinuous" regeneration and myofibril formation. Lab. Invest. 13: 1279, 1964. MedlineGoogle Scholar15. KLINKERFUSS GH: An electron microscopic study of myotonic dystrophy. Arch. Neurol. (Chicago) 16: 181, 1967. CrossrefMedlineGoogle Scholar16. BOEHMETHERMANNGOLD DHJ: Structural and ultrastructural changes in striated human muscle caused by chronic ischemia. Amer. J. Path. 49: 569, 1966. MedlineGoogle Scholar17. ISRAELKALANT YH: Effect of ethanol on the transport of sodium in frog skin. Nature (London) 200: 476, 1963. CrossrefMedlineGoogle Scholar18. ISRAEL-JACARDKALANT YH: Effect of ethanol on electrolyte transport and electrogenesis in animal tissues. J. Cell. Comp. Physiol. 65: 127, 1965. CrossrefMedlineGoogle Scholar19. KNUTSSON E: Effects of ethanol on the membrane potential and membrane resistance of frog muscle fibres. Acta Physiol. Scand. 52: 242, 1961. CrossrefMedlineGoogle Scholar20. SCHOTLANDSPIROROWLANDCARMEL DLDLPP: Ultrastructural studies of muscle in McArdle's disease. J. Neuropath. Exp. Neurol. 24: 629, 1965. CrossrefMedlineGoogle Scholar21. PRICEPEASEPEARSON HMDCCM: Selective actin filament and Z-band degeneration induced by plasmocid. An electron microscopic study. Lab. Invest. 11: 549, 1962. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Louis, MissouriFrom the Departments of Neurology, Medicine, and Pathology, Washington University School of Medicine, and the Washington University Medical Service and the Snodgrass Laboratory, St. Louis City Hospital (Max S. Starkloff Division), St. Louis, Mo.These studies were supported by research grants AM 08377, AM 15062, NB 04513, 5-SO-1 FR 538905, and FR-36, the U. S. Public Health Service, Washington, D. C., and by grants from the Beaumont May Institute of Neurology and from the Institute of Medical Education and Research of the City of St. Louis, Mo.Portions of these studies were presented at the 48th Annual Session of the American College of Physicians, April 14, 1967, San Francisco, Calif.Requests for reprints should be addressed to Gerald T. Perkoff, M.D., St. Louis City Hospital, 1515 Lafayette Ave., St. Louis, Mo. 63104. 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Part-IIIRecent contributions to the diagnosis of muscle diseaseMETABOLIC MYOPATHIESAlcoholic Muscle DiseaseMULTIPLE SERUM ENZYME ANALYSES IN CHRONIC ALCOHOLICSAlcoholic myopathyNeurologic complications of alcoholismEffect of Ergometric Exercise on the Activity in the Serum of Creatine Phosphokinase, Glutamate-Oxaloacetate Transminase and Aldolase in Rheumatoid ArthritisMEDICAL EDUCATION AND THE COMMON MARKETALCOHOLIC MYOPATHYA Spectrum of Myopathy Associated with Alcoholism I. Clinical and Laboratory FeaturesGERALD T. PERKOFF, M.D., F.A.C.P., MARCONI M. DIOSO, M.D., VIRGIL BLEISCH, M.D., GEORGE KLINKERFUSS, M.D.Alcohol and the HeartCARL S. ALEXANDER, M.D. 1 September 1967Volume 67, Issue 3_Part_1Page: 493-510KeywordsAlcoholismHealth services researchHospital medicineMedical educationMedical servicesNeurologyPathology and laboratory medicineResearch grantsResearch laboratoriesSkeletal muscles ePublished: 1 December 2008 Issue Published: 1 September 1967 PDF downloadLoading ...