<scp>l</scp>-Thyroxine plus Liothyronine in Hypothyroidism
Authors: Jean Eisinger
Journal: Annals of Internal Medicine (2005)

Letters4 October 2005l-Thyroxine plus Liothyronine in HypothyroidismJean Eisinger, MDJean Eisinger, MDFrom Centre Hospitalier de Toulon, F83056 Toulon, France.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-7-200510040-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Although hypothyroid patients have been treated for decades with desiccated thyroid extracts, l-thyroxine is now considered the only therapy. However, several studies have demonstrated differences between the effects of l-thyroxine and liothyronine, and liothyronine has been used in some heart and muscular conditions. Deiodination abnormalities could be induced by casual events, such as selenium deficiency, or by chronic disease.Bunevicius and colleagues (1) demonstrated that hypothyroid patients feel better when they receive combination therapy with l-thyroxine and liothyronine. Escobar-Morreale and colleagues (2) seem to support this patient preference but conclude with arguments that “physiologic combinations of l-thyroxine ...References1. Bunevicius R, Kazanavicius G, Zalinkevicius R, Prange AJ. Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism. N Engl J Med. 1999;340:424-9. [PMID: 9971866] CrossrefMedlineGoogle Scholar2. Escobar-Morreale HF, Botella-Carretero JI, Gomez-Bueno M, Galan JM, Barrios V, Sancho J. Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing L-thyroxine plus liothyronine with L-thyroxine alone. Ann Intern Med. 2005;142:412-24. [PMID: 15767619] LinkGoogle Scholar3. Khaleeli AA, Gohil K, McPhail G, Round JM, Edwards RH. Muscle morphology and metabolism in hypothyroid myopathy: effects of treatment. J Clin Pathol. 1983;36:519-26. [PMID: 6841646] CrossrefMedlineGoogle Scholar4. Eisinger J, Marie PA, Fontaine G, Calendini C, Ayavou T. Métabolisme énergétique et statut antioxydant au cours de myalgies. I-Hypothyroïdie. Lyon Mediterr Med Med Sud Est. 1966;32:2167-70. Google Scholar Author, Article, and Disclosure InformationAffiliations: From Centre Hospitalier de Toulon, F83056 Toulon, France.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThyroid Hormone Replacement Therapy in Primary Hypothyroidism: A Randomized Trial Comparing l-Thyroxine plus Liothyronine with l-Thyroxine Alone Héctor F. Escobar-Morreale , José I. Botella-Carretero , Manuel Gómez-Bueno , José M. Galán , Vivencio Barrios , and José Sancho l-Thyroxine plus Liothyronine in Hypothyroidism José I. Botella-Carretero and Héctor F. Escobar-Morreale Metrics 4 October 2005Volume 143, Issue 7Page: 543KeywordsConflicts of interestHeartHypothyroidismLongitudinal studiesScientistsSeleniumThyroidThyroxine ePublished: 4 October 2005 Issue Published: 4 October 2005 CopyrightCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...