Abnormal Cutaneous Innervation in Multiple Endocrine Neoplasia, Type 2b
Authors: J. A. CARNEY
Journal: Annals of Internal Medicine (1981)

Brief Reports1 March 1981Abnormal Cutaneous Innervation in Multiple Endocrine Neoplasia, Type 2bJ. A. CARNEY, M.D., Ph.D., A. B. HAYLES, M.D., A. G. E. PEARSE, M.D., H. O. PERRY, M.D., G. W. SIZEMORE, M.D.J. A. CARNEY, M.D., Ph.D.Search for more papers by this author, A. B. HAYLES, M.D.Search for more papers by this author, A. G. E. PEARSE, M.D.Search for more papers by this author, H. O. PERRY, M.D.Search for more papers by this author, G. W. SIZEMORE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-3-362 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1972 Baum (1) reported an abnormal histamine skin test in a patient with medullary thyroid carcinoma, pheochromocytoma, and mucosal neuromas—multiple endocrine neoplasia, type 2b (2); there was no flare around the wheal. Baum proffered two hypothetical explanations for the defect: an abnormal axon reflex due to a neural lesion; and rapid degradation of histamine by a substance, such as histaminase, secreted by medullary thyroid carcinoma. Herein we confirm Baum's finding of an abnormal response to histamine skin test in patients with multiple endocrine neoplasia, type 2b; report diffuse enlargement of cutaneous nerves in these patients; and suggest a possible...References1. BAUM J. Abnormal intradermal histamine reaction in the syndrome of pheochromocytoma, medullary carcinoma of the thyroid gland and multiple mucosal neuromas. N Engl J Med. 1971;284:963-4. CrossrefMedlineGoogle Scholar2. CHONGBEAHRSSIZEMOREWOOLNER GOGL. Medullary carcinoma of the thyroid gland. Cancer. 1975;35:695-704. CrossrefMedlineGoogle Scholar3. BROWNCOLLETASHJIAN REA. The syndrome of multiple mucosal neuromas and medullary thyroid carcinoma in childhood: importance of recognition of the phenotype for the early detection of malignancy. J Pediatr. 1975;86:77-83. CrossrefMedlineGoogle Scholar4. LEWIS T. The Blood Vessels of the Human Skin and Their Responses. London: Shaw and Sons; 1927. Google Scholar5. COOPER I. A neurologic evaluation of the cutaneous histamine reaction. J Clin Invest. 1950;29:465-9. CrossrefMedlineGoogle Scholar6. SONNENSCHEINBERNSTEIN RM. Relationship to the central nervous system of neural pathways mediating histamine flare and nicotine sweating. J Appl Physiol. 1957;11:481-5. CrossrefMedlineGoogle Scholar7. DYCKCARNEYSIZEMOREOKAZAKIBRIMIJOINLAMBERT PJGHWE. Multiple endocrine neoplasia, type 2b: phenotype recognition; neurologic features and their pathologic basis. Ann Neurol. 1979;6:302-14. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Mayo Clinic and Medical School Rochester, Minnesota Royal Postgraduate Medical School London England PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySkin Lesions in Hereditary Endocrine Tumor SyndromesA catalogue of multiple congenital anomaly syndromesMucosal neuromata syndrome (MEN type IIb (III)).Cutaneous Markers of Internal MalignancyLinear cutaneous neuromas (dermatoneurie en stries): a limited phakomatosis with striated pigmentation corresponding to cutaneous hyperneury (featuring multiple endocrine neoplasia syndrome?)Multiple endocrine neoplasia syndromesCutaneous Neuropathology in Multiple Endocrine Neoplasia, Type 2b 1 March 1981Volume 94, Issue 3Page: 362-363KeywordsHistamineLesionsMedullary thyroid carcinomaMultiple endocrine neoplasiaNervesPatientsPheochromocytomaReflexesSkin tests Issue Published: 1 March 1981 PDF DownloadLoading ...