tbuckley/cabot-search huggingface dataset:
Type 2 diabetes mellitus is associated with impaired cytokine response and adhesion molecule expression in human endotoxemia
Authors: Anne Sofie Andreasen, Theis Pedersen-Skovsgaard, Ronan M. G. Berg, Kira Dynnes Svendsen, Bo Feldt-Rasmussen, Bente K. Pedersen, Kirsten Møller
Journal: Intensive Care Medicine (2010)
Natural Selection against Protein Aggregation on Self-Interacting and Essential Proteins in Yeast, Fly, and Worm
Authors: Y. Chen, N. V. Dokholyan
Journal: Molecular Biology and Evolution (2008)

Protein aggregation is the phenomenon of protein self-association potentially leading to detrimental effects on physiology, which is closely related to numerous human diseases such as Alzheimer's and Parkinson's disease. Despite progress in understanding the mechanism of protein aggregation, how natural selection against protein aggregation acts on subunits of protein complexes and on proteins with different contributions to organism fitness remains largely unknown. Here, we perform a proteome-wide analysis by using an experimentally validated algorithm TANGO and utilizing sequence, interactomic and phenotype-based functional genomic data from yeast, fly, and nematode. We find that proteins that are capable of forming homooligomeric complex have lower aggregation propensity compared with proteins that do not function as homooligomer. Further, proteins that are essential to the fitness of an organism have lower aggregation propensity compared with nonessential ones. Our finding suggests that the selection force against protein aggregation acts across different hierarchies of biological system.
TCT-96 Influence Of Gender On Clinical Outcomes Following Transcatheter Aortic Valve Implantation: Results From The UK TAVI Registry On Behalf Of The UK TAVI Steering Group And The National Institute For Cardiovascular Outcomes Research
Authors: Rasha Al-Lamee, Christopher Broyd, Jessica Parker, Justin Davies, Jamil Mayet, Nilesh Sutaria, Ben Ariff, Beth Unsworth, John Cousins, Colin Bicknell, Jon Anderson, Iqbal Malik, Andrew Chukwuemeka, Neil Moat, Peter Ludman, Darrel Francis, Ghada Mikhail
Journal: Journal of the American College of Cardiology (2012)
MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte–associated antigen 4
Authors: Enikö Sonkoly, Peter Janson, Marja-Leena Majuri, Terhi Savinko, Nanna Fyhrquist, Liv Eidsmo, Ning Xu, Florian Meisgen, Tianling Wei, Maria Bradley, Jan Stenvang, Sakari Kauppinen, Harri Alenius, Antti Lauerma, Bernhard Homey, Ola Winqvist, Mona Ståhle, Andor Pivarcsi
Journal: Journal of Allergy and Clinical Immunology (2010)
Myocardial oxygenation in dogs during partial and complete coronary artery occlusion.
Authors: W J Parsons, J C Rembert, R P Bauman, F G Duhaylongsod, J C Greenfield, C A Piantadosi
Journal: Circulation Research (1993)

Regional myocardial oxygenation was assessed during partial and complete coronary artery occlusion using near infrared spectroscopy. In eight open-chest dogs, partial occlusions resulting in an approximately 42% decrease in left anterior descending coronary artery (LAD) blood flow produced an approximately 21% decrease in tissue O2 stores (tissue oxyhemoglobin plus oxymyoglobin) and no change in the oxidation level of mitochondrial cytochrome aa3. An approximately 81% reduction in LAD blood flow produced nadir levels of tissue oxyhemoglobin plus oxymyoglobin, maximal levels of deoxyhemoglobin plus deoxymyoglobin, a decline in tissue blood volume, and an approximately 39% decrease in cytochrome aa3 oxidation level. These changes were associated with an approximately 52% decrease from the preischemic baseline in mean transmural myocardial blood flow, measured by radiolabeled microspheres, and an approximately 41% decrease in myocardial O2 consumption. Complete occlusion resulted in further decreases in myocardial blood flow, O2 consumption, tissue blood volume, and cytochrome aa3 oxidation state but also produced increases in tissue O2 stores to above the nadir levels noted during partial occlusion. These results indicate that decreases in O2 delivery during partial coronary occlusion increase O2 extraction to sustain mitochondrial O2 availability, but as little as a 52% reduction in myocardial blood flow produces maximal O2 extraction and depletion of tissue O2 stores. Mitochondrial O2 availability is restricted further during complete occlusion because of limited O2 delivery and, possibly, decreases in tissue blood volume and O2 extraction.
Autosomal dominant transmission of gouty arthritis with renal disease in a large Japanese family.
Authors: N Yokota, H Yamanaka, Y Yamamoto, S Fujimoto, T Eto, K Tanaka
Journal: Annals of the Rheumatic Diseases (1991)

Six generations of a Japanese family had gouty arthritis and progressive nephropathy. Data on nine of 51 women (18%) and 15 of 66 men (23%) with either asymptomatic hyperuricaemia, gouty arthritis, or renal insufficiency were obtained. Renal function in four men and one woman with hyperuricaemia or gouty arthritis was also examined. Urinary excretion of uric acid was decreased in all subjects examined, including the young. Erythrocyte phosphoribosylpyrophosphate synthetase and hypoxanthine-guanine phosphoribosyltransferase activities determined in 10 patients were normal. Some patients had been treated with allopurinol to reduce serum uric acid concentrations, but the treatment did not prevent progression of renal impairment. Transmission of the disease in this large family is considered to be autosomal dominant. The data suggest that the disease in this family is the same entity as that described by other workers--that is, familial urate nephropathy. As far as is known this is the largest family with this disease so far reported.
Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells
Authors: Romain Gioia, Cédric Leroy, Claire Drullion, Valérie Lagarde, Gabriel Etienne, Stéphanie Dulucq, Eric Lippert, Serge Roche, François-Xavier Mahon, Jean-Max Pasquet
Journal: Blood (2011)
<i>In Vivo</i> Radioimaging of Bradykinin Receptor B1, a Widely Overexpressed Molecule in Human Cancer
Authors: Kuo-Shyan Lin, Jinhe Pan, Guillaume Amouroux, Gulisa Turashvili, Felix Mesak, Navjit Hundal-Jabal, Maral Pourghiasian, Joseph Lau, Silvia Jenni, Samuel Aparicio, François Bénard
Journal: Cancer Research (2014)

Abstract The bradykinin receptor B1R is overexpressed in many human cancers where it might be used as a general target for cancer imaging. In this study, we evaluated the feasibility of using radiolabeled kallidin derivatives to visualize B1R expression in a preclinical model of B1R-positive tumors. Three synthetic derivatives were evaluated in vitro and in vivo for receptor binding and their ability to visualize tumors by PET. Enalaprilat and phosphoramidon were used to evaluate the impact of peptidases on tumor visualization. While we found that radiolabeled peptides based on the native kallidin sequence were ineffective at visualizing B1R-positive tumors, peptidase inhibition with phosphoramidon greatly enhanced B1R visualization in vivo. Two stabilized derivatives incorporating unnatural amino acids (68Ga-SH01078 and 68Ga-P03034) maintained receptor-binding affinities that were effective, allowing excellent tumor visualization, minimal accumulation in normal tissues, and rapid renal clearance. Tumor uptake was blocked in the presence of excess competitor, confirming that the specificity of tumor accumulation was receptor mediated. Our results offer a preclinical proof of concept for noninvasive B1R detection by PET imaging as a general tool to visualize many human cancers. Cancer Res; 75(2); 387–93. ©2014 AACR.
Strategies for prevention of osteoporosis and hip fracture.
Authors: M R Law, N J Wald, T W Meade
Journal: BMJ (1991)

In England in 1985, 37600 people aged 65 years and over fractured a hip.' On average 3170 acute hospital beds a day were committed to people over 65 with hip fracture-nearly a quarter of all orthopaedic beds.Table I shows the age and sex distribution of patients with hip fracture.In all, 82% of those aged 65 and over were women, of whom 83% were aged 75 and over.On the basis of the present incidence (table II) almost one women in four living to the age of 90 in England can expect to have a hip fracture.Age specific rates TABLE i--Number of hospital discharges and deaths (rate per 10000 population) for fractured neck offemur, by age and sex in England, 1985 (from Hospital Inpatient Enquirv data') No (rate/1O 000)No (rate/10 000) Age (years) in men
Bleeding left hepatic artery pseudoaneurysm: a complication of endoscopic ultrasound-guided hepaticogastrostomy
Authors: V. Prachayakul, S. Thamtorawat, C. Siripipattanamongkol, P. Thanathanee
Journal: Endoscopy (2013)

A 66-year-old man, who had undergone pylorus-preserving pancreaticoduodenectomy with Roux-en-Y hepaticojejunostomy for cancer of the pancreatic head, developed recurrent obstructive jaundice. He underwent balloon-assisted endoscopic retrograde cholangiopancreatography (ERCP) with insertion of bilateral self-expandable metal stents (SEMSs).
Pediatric Bipolar Disorder: A Global Perspective
Authors: Gabrielle A. Carlson
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Website tracks progress towards UN millennium goals
Authors: Janice Hopkins Tanne
Journal: BMJ (2007)

the consultant pathologist whose failure to disclose the results of micro biological tests on one of Sally Clark's two baby sons led to the quashing of her murder convictions, lost his High Court appeal last week against a finding of serious professional misconduct.Mrs Clark was convicted in 1999 of kill ing babies Christopher and Harry but was cleared on appeal in 2003 after spending three and a half years in prison.She died earlier this year at the age of 42.A coroner ruled this week that the cause of her death was acute alcohol intoxication.A General Medical Council fitness to practise panel found Dr Williams, aged 58, guilty of serious professional misconduct in 2005 for not disclosing the results of tests on her second son, Harry, at or before her trial.Dr Williams was banned from doing Home Office forensic pathology or coro ners' work for three years, although he was allowed to continue working as a consult ant histopathologist at Macclesfield General Hospital, in Cheshire.His lawyers appealed on a range of issues, including delays in bringing his case before the GMC.But Mr Justice Davis ruled last week, "In my judg ment this appeal fails on essentially every ground advanced.There was no procedural unfairness giving rise to injustice; nor were the findings and conclusions of the panel wrong."Mrs Clark was cleared after a second appeal, when previously unreported micro biological results came to light.They showed the presence of Staphylococcus aureus at eight sites of the baby's body, including cerebro spinal fluid, raising the possibility that Harry died from natural causes.Dr Williams told the GMC panel that he had not considered the tests to be relevant and that if the defence had wished to see them, they should have asked for them. Court upholds GMC decision over Sally Clark case pathologistUK NEWS Charity warns of proposed restrictions to asylum seekers' access to care, p 1012 World NEWS �erck to pay ���n in rofeco�i� claims, p 1011 �erck to pay ���n in rofeco�i� claims, p 1011 , p 1011 �mj.com �o�ernment may lea�e some patients out of 1�� week tar�et �o�ernment may lea�e some patients out of 1�� week tar�et
Reproducibility and comparison of responses to inhaled histamine and methacholine.
Authors: E F Juniper, P A Frith, C Dunnett, D W Cockcroft, F E Hargreave
Journal: Thorax (1978)

The efficiency of a standardised inhalation test procedure was studied by examining the reproducibility of responses to histamine and methacholine. In addition, the responses to the two agents were compared. Each set of duplicate tests was carried out on a separate day within one week, and all factors known or presumed to influence responses were carefully controlled. The results were expressed as the provocative concentration of the agent causing a 20% fall in forced expired volume in one second (PC20). Responses to histamine and methacholine were highly reproducible (coefficients of determination [r2] = 0.994 and 0.990 respectively). Responsiveness to histamine correlated closely with responsiveness to methacholine (r2 = 0.85). There was a small but significant cumulative dose effect with methacholine (P less than 0.01) but not with histamine. Side effects of throat irritation, flushing, and headache were more frequent with histamine than methacholine, and were dose-related. The high level of reproducibility indicates the efficiency of the test procedure. The similar severity of effects by agents with different mechanisms of action suggests that the primary cause of non-specific bronchial hyperreactivity lies at the level of bronchial smooth muscle.
High-carbohydrate diets and insulin-dependent diabetics.
Authors: N M O'Mullane
Journal: BMJ (1979)

1893, 100 years after Jenner's pioneering cowpox experiments in the English countryside.My grandfather would have been gratified to learn that his method for purifying the lymph containing the virus had remained essentially the same for almost another century (surely a medical therapeutic record ?).During this time one of the most loathsome of communicable diseases has been extirpated and is medical history.Those of us from the medical schools of St Thomas's and Westminster, where Monckton Copeman was student and pedagogue, have another reason to be proud.
Functional Gastrointestinal Disorders
Authors: J. E. Lennard-Jones
Journal: New England Journal of Medicine (1983)

IN most of us the the gastrointestinal tract is quiet, unobtrusive, and efficient, but it gives trouble to at least one person in three. Often symptoms are slight, and simple traditional remedies suffice. A few people experience recurrent or constant symptoms that are severe enough to be disabling and for which no explanation can be found. The symptoms of at least one fifth of the patients who consult a gastroenterologist remain unexplained.1 , 2 The clinical problem of functional gastrointestinal symptoms cannot be ignored.DefinitionFor the purpose of this review, a functional symptom is defined as one for which no structural, . . .
Engineered neural tissue for peripheral nerve repair
Authors: Melanie Georgiou, Stephen C.J. Bunting, Heather A. Davies, Alison J. Loughlin, Jonathan P. Golding, James B. Phillips
Journal: Biomaterials (2013)

A new combination of tissue engineering techniques provides a simple and effective method for building aligned cellular biomaterials. Self-alignment of Schwann cells within a tethered type-1 collagen matrix, followed by removal of interstitial fluid produces a stable tissue-like biomaterial that recreates the aligned cellular and extracellular matrix architecture associated with nerve grafts. Sheets of this engineered neural tissue supported and directed neuronal growth in a co-culture model, and initial in vivo tests showed that a device containing rods of rolled-up sheets could support neuronal growth during rat sciatic nerve repair (5 mm gap). Further testing of this device for repair of a critical-sized 15 mm gap showed that, at 8 weeks, engineered neural tissue had supported robust neuronal regeneration across the gap. This is, therefore, a useful new approach for generating anisotropic engineered tissues, and it can be used with Schwann cells to fabricate artificial neural tissue for peripheral nerve repair.
Nephrotic syndrome in vesicoureteric reflux.
Authors: H F Woods, J Walls
Journal: BMJ (1976)

experienced attacks of similar pain occurring once or twice a week with no systemic upset or alteration of bowel habit.His temperature was 38'C, and there was tenderness and guarding in the right iliac fossa.Rectal examination showed normal stools and right-sided tenderness.White cell count was 15 x 109/1 (15 000/mm3) with 70 % neutrophils, haemoglobin 14-6 g/dl.At
Disparate mechanisms for hypoxic cell injury in different nephron segments. Studies in the isolated perfused rat kidney.
Authors: M Brezis, P Shanley, P Silva, K Spokes, S Lear, F H Epstein, S Rosen
Journal: Journal of Clinical Investigation (1985)

Hypoxic injury was evaluated morphologically in the proximal tubule and in the medullary thick ascending limb of isolated rat kidneys perfused for 90 min without O2 or with various metabolic inhibitors. Inhibition of mitochondrial respiration (with rotenone, antimycin, oligomycin) or of intermediary metabolism (with monofluoroacetate, malonate, 2-deoxyglucose) caused reduction in renal oxygen consumption, renal function, and ATP content comparable with those elicited by oxygen deprivation. Metabolic inhibition produced hypoxiclike injury in the first portions of the proximal tubule, S1 and S2 ("clubbing" of microvilli, mitochondrial swelling), and the extent of damage was correlated with the degree of ATP depletion. In the third portion of the proximal tubule, S3, hypoxiclike damage (cytoplasmic edema or fragmentation) occurred most consistently when both aerobic and anaerobic metabolism were inhibited simultaneously. In the medullary thick ascending limb, none of the metabolic or mitochondrial inhibitors used could reproduce the injury of oxygen deprivation. Thus, the proximal tubule and the thick ascending limb have markedly different responses to cellular energy depletion, suggesting disparate mechanisms for hypoxic injury along the nephron.
ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes
Authors: Nandini Mondal, Alexander Buffone, Gino Stolfa, Aristotelis Antonopoulos, Joseph T. Y. Lau, Stuart M. Haslam, Anne Dell, Sriram Neelamegham
Journal: Blood (2014)
Accurate Description of DNA-Based Noninvasive Prenatal Screening
Authors: Sau W Cheung, Ankita Patel, Tak Y Leung
Journal: New England Journal of Medicine (2015)

1675 67) had mild weakness in the arms or legs. 2 In addition, motor-conduction studies in patients with the above-mentioned variants have shown decreased action potential in compound muscle but no change in other measures of motor conduction. 3In one patient among several with overlap of the Miller Fisher syndrome and the pharyngeal-cervical-brachial variant described by Ropper in 1986, 15 seconds of isometric exercise of various muscles on three occasions caused an increase of 10 to 45% in the amplitude of the compound muscle action potential. 4Consequently, a definitive diagnosis can be reached only when confirmed by laboratory tests for anti-GQ1b IgG antibodies, whose results may not be returned for several days.
Shoulder disorders in general practice: incidence, patient characteristics, and management.
Authors: D A van der Windt, B W Koes, B A de Jong, L M Bouter
Journal: Annals of the Rheumatic Diseases (1995)

To study the incidence and management of intrinsic shoulder disorders in Dutch general practice, and to evaluate which patient characteristics are associated with specific diagnostic categories. In 11 general practices (35,150 registered patients) all consultations concerning shoulder complaints were registered during a period of one year. Patients with an intrinsic shoulder disorder who had not consulted their general practitioner for the complaint during the preceding year (incident cases) were asked to participate in an observational study. Participants completed a questionnaire regarding the nature and severity of their complaints. The general practitioners recorded data on diagnosis and therapy. The cumulative incidence of shoulder complaints in general practice was estimated to be 11.2/1000 patients/year (95% confidence limits 10.1 to 12.3). Rotator cuff tendinitis was the most frequently recorded disorder (29%). There were 349 incident cases enrolled in the observational study. Patient characteristics showed small variations between different diagnostic categories. Age, duration of symptoms, precipitating cause and restriction of movement seemed to be discriminating factors. Twenty two percent of all participants received injections during the first consultation; most (85%) were diagnosed as having bursitis. The majority of patients with tendinitis (53%) were referred for physiotherapy. With respect to diagnosis and treatment, the practitioners generally appeared to follow the guidelines issued by the Dutch College of General Practitioners. Although the patient characteristics of specific disorders showed some similarities with the clinical pictures described in the literature, further research is required to demonstrate whether the proposed syndromes indeed constitute separate disorders with a different underlying pathology, requiring different treatment strategies.
The Role of Prophylactic Oophorectomy in the Treatment of Carcinoma of the Breast.
Authors: Fred G. Conrad
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970The Role of Prophylactic Oophorectomy in the Treatment of Carcinoma of the Breast.Fred G. Conrad, M.D., F.A.C.P.Fred G. Conrad, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-800_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptUSAF Central Tumor Registry records of breast carcinoma involving patients seen and treated at USAF medical treatment centers during the past 15 years were used to evaluate the role of prophylactic oophorectomy.A total of 1,416 patients were evaluated. Eighty-three had disseminated disease or were inoperable when initially seen. Nineteen patients had in situ disease. Seven hundred thirty-four patients had positive axillary lymphadenopathy, and in 580 patients the disease was localized within the breast tissue at the time of primary therapy. Three hundred eighty-six patients underwent prophylactic oophorectomy, that is, surgical extirpation of all ovarian tissue, at a time when... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Lackland AFB, Tex. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 800-801KeywordsBreast cancerBreast tissueMetastasisOophorectomy Issue Published: 1 May 1970 PDF downloadLoading ...