tbuckley/cabot-search huggingface dataset:
Blood and liver-infiltrating lymphocytes in primary biliary cirrhosis: Increase in activated T and natural killer cells and recruitment of primed memory T cells
Authors: Anna Björkland, Roger Festin, Ib Mendel-Hartvig, Anders Nyberg, Lars Lööf, Thomas H. Tötterman
Journal: Hepatology (1991)

We used two-color and three-color flow cytometric analysis to study phenotypical activation and functional subsets of T and natural killer cells in the blood and liver tissue of patients with primary biliary cirrhosis, other chronic liver diseases and the blood of healthy subjects. The changes in blood lymphocyte phenotype in patients with primary biliary cirrhosis and other chronic liver diseases were similar and comprised elevated relative or absolute numbers of activated human leukocyte antigen-DR+ T subset (CD4+ and CD8+) cells and DR+ natural killer-like (CD16+) cells. B cell (CD19+) numbers were normal. In primary biliary cirrhosis a selective reduction in T cells of suppressor-inducer (CD45RA+ CD4+) type was registered. The human leukocyte antigen-DR expression among CD4 + T cell subsets was investigated further in primary biliary cirrhosis and healthy controls using triple antibody flow cytometric analysis. Phenotypical cell activation was confined to helper T cells of the primed, memory (CD45RO + CD4+) type. The decrease in suppressor-inducer T cells in primary biliary cirrhosis was paralleled by a reciprocal increase in primed memory T cells. Several significant differences were observed when blood and liver-infiltrating cells from primary biliary cirrhosis patients were compared. In the liver tissue, the CD4/CD8 ratio was decreased, the relative activation of T-subset cells and NK cells was further increased, the suppressor-inducer T subset was further depressed and the primed memory T subset was increased. The cytotoxic T-cell subset (CD11b − ) dominated within the CD8+ population. In liver tissue from other chronic liver disease subjects, a lower CD4/CD8 ratio was found compared with primary biliary cirrhosis. However, the infiltrate was relatively similar to primary biliary cirrhosis, indicating a common inflammatory pattern. (Hepatology 1991;13:1106-1111.)
Letter: Ocular reactions to beta-blockers.
Authors: J R Lyall
Journal: BMJ (1975)

cadaver arm to be achieved.Separate measurements of trabecular bone mass, cortical bone mass, and bone mineral concentration have also been achieved in patients.The results of this study have been presented in March 1975 at the International Symposium on Computer Tomo- graphy in Bermuda and will be further ad- vanced at the European Society of Radiology in Edinburgh in June.It is important to stress that these results were obtained by modification of the E.M.I. brain scanner where the existence of a surrounding water reference makes accurate and absolute re- sults possible.-Weare, etc.,
Stadium Coronary Care
Authors: Ira Kassanoff
Journal: JAMA (1972)

An emergency "life support station" was established at the Atlanta Stadium as part of a research program to elucidate the mechanism or precipitating events, or both, for the onset of myocardial infarction and sudden cardiac death, and to suggest appropriate therapeutic intervention. An emergency unit was also operated at Grant Field, the Georgia Tech football stadium. Anecdotal information in recent years had suggested that at least one acute event occurred at most stadium events with an attendance of more than 30,000 to 40,000 persons. However, Atlanta Stadium first aid station records for the years 1966 to 1969 showed only 20 reported episodes of apparent myocardial infarction, with or without sudden cardiac death. The research effort was thus designed to ascertain the incidence of apparent sudden cardiac death, to better define the clinical presentation and associated events, and to evaluate the feasibility of therapeutic intervention utilizing a well-staffed and well-equipped emergency
Response to Comments on Brethauer et al. Bariatric Surgery Improves the Metabolic Profile of Morbidly Obese Patients With Type 1 Diabetes. Diabetes Care 2014;37:e51–e52
Authors: John P. Kirwan, Stacy A. Brethauer, Ali Aminian, Raul J. Rosenthal, Sangeeta R. Kashyap, Philip R. Schauer
Journal: Diabetes Care (2014)

We thank Middelbeek and Brown (1) for their interest in our work and for their comments on our article (2) about the effects of bariatric surgery in type 1 diabetes. We agree with their view that the metabolic responses to bariatric surgery in severely obese patients with type 1 diabetes are poorly understood. Hence, we thought it was important to publish our data, albeit limited to a retrospective analysis of 10 patients with type 1 diabetes who underwent bariatric surgery at the Cleveland Clinic. They point out that we did not distinguish whether our patients were being treated by continuous subcutaneous insulin infusion (CSII) or multiple …
Value of FDG PET/CT in Staging of Oral Cancer
Authors: Christian Linz, Urs D.A. Müller-Richter, Stefan Kircher, Constantin Lapa, Christina Bluemel
Journal: Clinical Nuclear Medicine (2015)

Patients with squamous cell cancer (SCC) of the head and neck are at increased risk for second primary malignancies (SPMs). We report on a 53-year-old patient with primary diagnosis of SCC in the anterior floor of the mouth. Panendoscopy suspected an SPM of the right vocal cord. FDG PET/CT, as a whole-body imaging method, confirmed this suspicion and raised concern for further SPM of both esophagus and colon. All malignancies were confirmed by biopsy. Subsequently, the patient underwent radiochemotherapy. In summary, FDG PET/CT revealed unexpected multiple SPMs, prevented unnecessary resection of the oral SCC, and enabled individualized therapeutic management.
Supermarkets with the most Campylobacter infected chickens will be named and shamed next week
Authors: I. Torjesen
Journal: BMJ (2014)

A Food Standards Agency report due to be published next week will show which fresh supermarket chickens are most likely to be infected with Campylobacter , and Public Health England hopes that this will urge the major supermarket chains to pressure their suppliers to bring down infection rates.

Public Health England was contracted by the Food Standards Agency to measure Campylobacter contamination in fresh raw chickens sold by UK supermarkets and butchers over a 12 month period. The first results, which were published in August, showed that the contamination rate was around 60%, but they did not break this down by retailer. The next set of quarterly results will do so, and it is expected to show higher infection rates.

Frieda Jorgensen, of Public Health England’s food, water, and environmental laboratory, told a press briefing in London on 18 November, “We know more chicken stocks tend to be Campylobacter positive in the summer, [so] it is highly likely that the contamination rate for retail chickens will be higher for …
Family Dynamics and Family Psychotherapy of Psychosomatic Disorders
Authors: M. Wirsching, H. Stierlin
Journal: Psychotherapy and Psychosomatics (1979)

Family therapy of psychosomatic disorders is often difficult and comparable to the therapy of psychotic patients. Nonetheless, the results published today by authors such as Minuchin and Selvini and our own experiences are promising indeed. We have found that what seemed to be a deep-rooted psychic structure changed rapidly and enduringly if the relationship field changed. Amelioration of symptoms is in many cases easily attained if they are understood in their function within a relational system. Also, we regard the system or family approach as a chance for medical practice. The general practitioner who usually deals with family systems has, in our view, an ideal position to bring about change if he uses his authority and trust properly. He has to obtain a positive, not pathology-oriented view and should use family and social resources in spite of engaging in an often fruitless and endless contact with the designated patient, which only serves to maintain and even to increase the homeostatic lock of the family system.
PARALYSIS OF THE FACIAL NERVE IN CONNECTION WITH DISEASES OF THE EAR.
Authors: LAURENCE TURNBULL
Journal: JAMA (1883)

[Read before the Section on Ophthalmology, Otology and Laryngology of the American Medical Association, June, 1883.] Diseases of the ear and their connection with general medicine is a subject of grave importance, and the general practitioner who neglects or omits their study will often fall into serious errors of diagnosis, and of necessity be unsuccessful in treatment. Acute and chronic disease of the middle ear will give rise to temporary or permanent facial paralysis, alteration in taste or smell, sight, and even gait. False epiliptiform convulsions, hemiplegia and insanity are also due to reflex phenomena, from irritation and compression of the sensory and motor nerves of the ear, or the result of necrosis of portions of the temporal bone. It is now a well recognized fact that pyæmic abscesses in the brain and some forms of rheumatic fever have their starting point in the middle ear. Paralysis of the parts
<i>In Silico</i> Analysis of Sequential, Structural and Functional Diversity of Wheat Cystatins and Its Implication in Plant Defense
Authors: Shriparna Dutt, V.K. Singh, Soma S. Marla, Anil Kumar
Journal: Genomics Proteomics & Bioinformatics (2010)

Phytocystatins constitute a multigene family that regulates the activity of endogenous and/or exogenous cysteine proteinases. Cereal crops like wheat are continuously threatened by a multitude of pathogens, therefore cystatins offer to play a pivotal role in deciding the plant response. In order to study the need of having diverse specificities and activities of various cystatins, we conducted comparative analysis of six wheat cystatins (WCs) with twelve rice, seven barley, one sorghum and ten corn cystatin sequences employing different bioinformatics tools. The obtained results identified highly conserved signature sequences in all the cystatins considered. Several other motifs were also identified, based on which the sequences could be categorized into groups in congruence with the phylogenetic clustering. Homology modeling of WCs revealed 3D structural topology so well shared by other cystatins. Protein-protein interaction of WCs with papain supported the notion that functional diversity is a con-sequence of existing differences in amino acid residues in highly conserved as well as relatively less conserved motifs. Thus there is a significant conservation at the sequential and structural levels; however, concomitant variations maintain the functional diversity in this protein family, which constantly modulates itself to reciprocate the diversity while counteracting the cysteine proteinases.
Safety of vaccinations. Miss America, the media, and public health
Authors: Gary L. Freed, Samuel L. Katz, Sarah J. Clark
Journal: JAMA (1996)

ON SEPTEMBER 17,1994, Heather Whitestone was chosen as  America, the first ever with a disability. Her deafness has been the subject of much media attention. On September 16, 1994, the Atlanta Constitution ran a story in its front section about Whitestone stating, At age 18 months, [she] almost died from an adverse reaction to a routine DPT (diphtheria, pertussis, tetanus) vaccination. It wiped out all but a tiny sliver of her hearing. 1 On September 18, the New York Times ran an Associated Press story in its first section stating Miss Whitestone... lost her hearing at 18 months because of a reaction to a diphtheria-tetanus shot. 2 On September 19 the New York Times ran another story ascribing her deafness to a vaccination. 3 Not until September 26 did the New York Times publish a story stating that Whitestone's deafness was not due to a vaccination but actually resulted
Day-Clinic and Inpatient Psychotherapy for Depression (DIP-D): A Randomized Controlled Pilot Study in Routine Clinical Care
Authors: Ulrike Dinger, Ottilia Klipsch, Johanna Köhling, Johannes C. Ehrenthal, Christoph Nikendei, Wolfgang Herzog, Henning Schauenburg
Journal: Psychotherapy and Psychosomatics (2014)
Myelomatosis with Lipaemia and Xanthomata
Authors: J. E. Lennard-Jones
Journal: BMJ (1960)

ANAEMIA OF PREGNANCY MBmTIm 781The existence of congenital -spherocytosis was suspected only when a persistent irregular reticulocyte response was observed after treatment with folic acid.We are grateful to Professor Hi. C. McLaren for permission to publish details from the case notes of the first pregnancy, and to Mr. A. L. Deason from those of the second pregnancy.The haematological investigation after our patient's first confinement,was carried out by the late Dr. A. L. Peeney.We are further
Abstract P1-13-04: Optimal duration of adjuvant chemotherapy for high risk node negative breast cancer patients: 6-year results of the prospective randomized phase III trial PACS 05.
Authors: P Kerbrat, B Coudert, B Asselain, C Levy, A Lortholary, A Marre, R Delva, M Rios, P Viens, E Brain, D Serin, M Edel, L Mauriac, M Campone, M-A Mouret-Reynier, T Bachelot, M-J Foucher-Goudier, L Roca, A-L Martin, H Roche
Journal: Cancer Research (2012)

Abstract BACKGROUND: In 2000, the NIH Consensus meeting concluded that 4 to 6 cycles of adjuvant chemotherapy appeared to provide an optimal benefit; So, we underwent a prospective randomized trial comparing 4 and 6 cycles of FEC 100 (JCO 2005; 23: 2686–2693) for high risk node negative breast cancer patients. METHODS: This study enrolled 18–65 y women with operable breast cancer, without axillary lymph node involvement, or presence of isolated tumor cells, with size superior to 1 cm and another poor prognostic factor: T &amp;gt; 2 cm, HR –, SBR grade II or III, age &amp;lt; 35 y. After adequate breast surgery and axillary lymph node dissection or sentinel node technique, they were randomized between arm A, 6 cycles of FEC 100, and arm B, 4 cycles, every three weeks. The local regional treatment was completed following usual recommendations. All HR+ patients received hormonal therapy for 5 years. After August 2005, patients with HER2+ tumors were excluded from this study. The primary end point was PFS at 5 years. This study was powered to detect a 6% difference in favour of 6 cycles. Between August 2002 and September 2006, 1516 patients were randomized; 1515 are analysed in ITT. Three patients in the B group did not receive any chemotherapy. There is no significant difference between the two arms for tumor and patient characteristics. RESULTS At a median follow-up of 73 months we observed regarding PFS a low event rate, 197 for the entire population (13%) 91 in arm A median PFS, vs. 106 in arm B median PFS, without any difference between the two groups for DFS, DDFS, local relapse, overall survival. There was no unexpected toxicity. In the arm A we observed more grade III and IV neutropenia, without congestive heart failure. CONCLUSION At a follow-up of 73 months, we observed a low relapse rate, with no significant difference between the two arms. Duration of FEC100 does not induce different outcomes in this population. Question of length of adjuvant treatment is still open with and without taxanes. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-13-04.
Ingestive and inhalative allergy to the mushroom <i>Boletus edulis</i>
Authors: R. Torricelli, S. G. O. Johansson, B. Wiithrich
Journal: Allergy (1997)

This is the first report on inhalative and ingestive allergy to the common edible mushroom Boletus edulis ( Be ) (English, edible boletus ; German, Steinpilz, French, bolet ; Italian, porcino or boleto ) belonging to the class Basidiomycetes. Four cases observed in our allergy unit are presented, showing different clinical manifestations of this rare allergy: as an occupational problem or life‐threatening anaphylactic reactions after eating Be. In all cases, skin prick‐to‐prick tests with raw Be were strongly positive; in three cases, specific IgE against Be could be found. The symptoms were reproducible after an inhalation challenge test. It is noteworthy that not only can Basidiomycetes cause airborne allergy but also that edible mushrooms from this class can cause inhalative and intestinal allergy. The two patients with strong anaphylactic reactions demonstrate that Be may have great allergenic potential.
Estradiol Benzoate and Progesterone in Advanced Human-Breast Cancer
Authors: Richard L. Landau
Journal: JAMA (1962)

9 of 15 patients, including 1 man, with advanced mammary cancer were improved by treatment with a combination of 50 mg of progesterone and 5 mg of estradiol benzoate administered intramuscularly every day. The effectiveness of estradiol and progesterone therapy was evaluated on the basis of its influence on the state of well-being of the patients, the relief of pain, changes in visible or palpable tumors, and alterations in bone metastases as revealed by X-ray examination. 7 of the 9 patients who improved with treatment had previously responded to endocrine therapy (adrenalectomy, hypophysectomy, castration, estrogen, or androgen). Serum alkaline phosphatase concentrations rose during the first 2 weeks of treatment in all patients in whom the disease ameliorat ed, but in only 2 of the 6 who were not improved. No toxic or adverse reactions were observed. Although the benefit secured by this treatment was sometimes short-lived, the results seemed sufficiently encouraging to merit more exhaustive trials.
In vitro effects of mineral fibers.
Authors: L D Palekar, P M Cook, D L Coffin
Journal: Environmental Health Perspectives (1983)

In vivo tests available to determine the toxicity of mineral fibers are too expensive and time-consuming to be regularly employed in the evaluation of the potential health hazard posed by natural and man-made fibers. In vitro procedures, while economical, convenient and capable of ranking "relative toxicity," are uncertain predictors of specific lesions. Thus, it is of interest to compare the results of various standard in vitro tests with the results of in vivo tests. Data are available for intratracheal and intrapleural exposures of animals to amphibole mineral fibers from UICC amosite and a fibrous form of ferroactinolite. This paper presents data from parallel in vitro studies employing these minerals. The methods used were mammalian erythrocyte lysis, Chinese hamster ovary cell clonal cytotoxicity assay, and rabbit alveolar macrophage cytotoxicity assay. The experiments were conducted in triplicate to determine dose effect by mass and by number of fibers with aspect ratios greater than 3. A comparison of relative toxicity was made between the ferroactinolite and amosite. In the erythrocyte system, there was a greater lytic effect per unit of fibers for ferroactinolite than for the UICC amosite.
Respiratory Syncytial Virus-Induced Host IFN Signaling Differs Between A549 and BEAS-2B Epithelial Cell Lines
Authors: Philippa Hillyer, Rachel E. Shepard, Megan Uehling, Faruk Sheik, Cindy Luongo, Ursula J. Buchholz, Peter L. Collins, Raymond P. Donnelly, Ronald L. Rabin
Journal: Journal of Allergy and Clinical Immunology (2015)
Balloon angioplasty with stent implantation in experimental coarctation of the aorta.
Authors: W R Morrow, V C Smith, W J Ehler, A F VanDellen, C E Mullins
Journal: Circulation (1994)

BACKGROUND Balloon angioplasty of coarctation of the aorta is an effective method of treatment but is complicated by tearing of the aortic intima, formation of aneurysms, and restenosis. Stent placement at the time of balloon dilation could prevent restenosis and could also prevent progression of intimal tears to aneurysms. The purpose of this study was to evaluate the feasibility of balloon dilation and implantation of balloon-expandable stents in an experimental model of coarctation and to examine the effect of stent placement at the site of surgically created stenosis. METHODS AND RESULTS Coarctation of the aorta was surgically produced in 11 juvenile swine. Simultaneous coarctation angioplasty and stent implantation was performed in 10 animals 34 +/- 7.8 days after surgery. Repeat catheterization was performed 59 +/- 6 days after stent implantation. Five animals underwent reexpansion of stents with subsequent follow-up catheterization. Aortic specimens were examined by light microscopy and scanning electron microscopy. Coarctation angioplasty with stent implantation was successful in all, with an increase in coarctation diameter from 46 +/- 8.5% to 90 +/- 12.2% of proximal aortic diameter (P = .0001). Systolic pressure gradient decreased from 32 +/- 19.8 to 0.5 +/- 2.8 mm Hg (P &lt; .001). All stents were patent at follow-up catheterization, with no evidence of intraluminal thrombosis. Reexpansion in five animals increased the stent diameter from a mean of 77.4 +/- 12.1% to 93 +/- 11.0% of proximal aortic diameter (P = .02). Gross examination of aortic specimens demonstrated formation of neointima over the stent wherever the stent struts were in contact with the aortic wall. The stent occupied a subintimal position and produced minimal compression of the underlying media. Medial compression was noted immediately beneath stent struts, but there was no evidence of intimal or medial dissection. CONCLUSIONS Balloon angioplasty with simultaneous implantation of balloon-expandable stents is effective in relieving aortic obstruction in experimental coarctation. Reexpansion of the rigid stent can be performed in an area of surgical aortotomy and coarctation without significant intimal or medial injury. Stent implantation may be useful in preventing restenosis and aneurysm formation after angioplasty of coarctation.
A Colour Atlas of Bone Disease
Authors: J. M. H. Moll
Journal: Annals of the Rheumatic Diseases (1981)

excellent chapter on a rapidly advancing front, the immunology of joints, by Michael Elves.The rare apparent omissions (on a quick reading and index consultation) may well be remedied in the second volume, for example, the angiogenesis inhibition factor of cartilage (first described in 1975) and amyloidosis in the aging joint capsule (described in 1976), both pertinent to this field.For clinicians (rheumatologists and orthopaedic surgeons) the book offers a compendium of knowledge in the basic sciences of their arts, well presented for the most part, well referenced and well indexed, and with adequate illustrations.The editor, Leon Sokoloff from the National Institutes of Health and, more recently, the State University of New York at Stony Brook-perhaps the premier physiopathologist in this field-and his colleagues are to be congratulated on this difficult but most worthwhile achievement.
NHS has not reaped fair benefits from refinancing of PFI schemes, MPs say
Authors: Michael Day
Journal: BMJ (2007)

An influential group of MPs has claimed that widespread financial incompetence is adding to the cost of the United Kingdom's controversial private finance initiative (PFI).The House of Commons Committee of Public Accounts made its new attack on the PFI after it discovered that the government had clawed back £100m (€145m; $200m) less than was predicted from the new private-public profit sharing schemes.The committee's chairman, the Conservative MP Edward Leigh, blamed the loss on the failure of Treasury officials to oversee key refinancing arrangements.In 2002 ministers introduced changes so that public sector bodies could share in some of the financial gains when big PFI loans were rearranged.Typically, these loans were renegotiated on a more favourable basis once PFI projects had been completed and the risks involved were lower.However, left to their own devices, officials in local hospitals had been out of their depth negotiating with their counterparts in the private sector, the committee says.In 2003 the Office of Government Commerce, which then had responsibility for PFI policy, told the public accounts committee that it expected the public sector to receive between £175m and £200m from the voluntary sharing arrangements in early PFI deals.However, up to December 2006 the government had secured the right to gains of only £93m."Proceeds gained by the public sector from PFI debt refinancing under the voluntary code for the sharing of gains are currently well short of expectations" said Mr Leigh.