tbuckley/cabot-search huggingface dataset:
Intense Activity in an Incisional Hernia on a Dynamic Study—an Incidental Finding
Authors: MOHANLAL C. MAKHIJA, SIDNEY SCHULTZ
Journal: Clinical Nuclear Medicine (1979)

From the Department of Radiology, Monmouth Medical Center, Long Branch, New Jersey Reprint requests: Mohanlal C. Makhija, M.D., Director, Nuclear Medicine Section, Monmouth Medical Center, 300 Second Avenue, Long Branch, New Jersey 07740.
CIBA-GEIGY Medical Computing Resource Guide (formerly PC Physician)
Authors: Leslie L. Cortés
Journal: JAMA (1992)

Software Galen is the first of my home computers to realize my vision of a physician workstation. This 33-Mhz, 386 PC-clone is equipped with 4 megabytes of RAM, a 200-megabyte hard disk, and SVGA graphics. Running Windows 3.0 under DOS 5.0, it fulfills my needs for database access, pediatric and internal medicine CD-ROM use, remote communications, writing, and programming. Software, as much as hardware, makes this possible. So, when<i>JAMA</i>asked me to review the<i>CIBA-GEIGY Medical Computing Resource Guide</i>(formerly called<i>PC Physician MCRG</i>), I couldn't refuse. <i>MCRG</i>is a Hypertext document for anyone who wants to use computers to grapple with medical problems. Version 2.1 encompasses computing information for physicians, nurses, dentists, educators, and medical office managers. It covers organizations and users' groups, bulletin boards and databases, interactive video and CD-ROM resources, medical computing periodicals, audiotapes, and books. If you are unfamiliar with Hypertext, don't be intimidated. Clinical
Embodiment is all in the head
Authors: Paul Cisek
Journal: Behavioral and Brain Sciences (2001)

I suggest that neurophysiological data, usually interpreted in cognitivist terms, is actually more supportive of dynamic frameworks such as that of Thelen et al. I outline a model of embodied action used to interpret neural data from frontal and parietal cortex, and suggest that it bears strong similarity to the framework described in the target article.
Pre-endoscopy serological testing for coeliac disease: evaluation of a clinical decision tool
Authors: Andrew D Hopper, Simon S Cross, David P Hurlstone, Mark E McAlindon, Alan J Lobo, Marios Hadjivassiliou, Marion E Sloan, Simon Dixon, David S Sanders
Journal: BMJ (2007)

<b>Objective</b> To determine an effective diagnostic method of detecting all cases of coeliac disease in patients referred for gastroscopy without performing routine duodenal biopsy. <b>Design</b> An initial retrospective cohort of patients attending for gastroscopy was analysed to derive a clinical decision tool that could increase the detection of coeliac disease without performing routine duodenal biopsy. The tool incorporated serology (measuring antibodies to tissue transglutaminase) and stratifying patients according to their referral symptoms (patients were classified as having a “high risk” or “low risk” of coeliac disease). The decision tool was then tested on a second cohort of patients attending for gastroscopy. In the second cohort all patients had a routine duodenal biopsy and serology performed. <b>Setting</b> Teaching hospital in Sheffield. <b>Participants</b> 2000 consecutive adult patients referred for gastroscopy recruited prospectively. <b>Main outcome measure</b> Evaluation of a clinical decision tool using patients9 referral symptoms, tissue transglutaminase antibody results, and duodenal biopsy results. <b>Results</b> No cases of coeliac disease were missed by the pre-endoscopy testing algorithm. The prevalence of coeliac disease in patients attending for endoscopy was 3.9% (77/2000, 95% confidence interval 3.1% to 4.8%). The prevalence in the high risk and low risk groups was 9.6% (71/739, 7.7% to 12.0%) and 0.5% (6/1261, 0.2% to 1.0%). The prevalence of coeliac disease in patients who were negative for tissue transglutaminase antibody was 0.4% (7/2000). The sensitivity, specificity, positive predictive value, and negative predictive value for a positive antibody result to diagnose coeliac disease was 90.9%, 90.9%, 28.6%, and 99.6%, respectively. Evaluation of the clinical decision tool gave a sensitivity, specificity, positive predictive value, and negative predictive value of 100%, 60.8%, 9.3%, and 100%, respectively. <b>Conclusions</b> Pre-endoscopy serological testing in combination with biopsy of high risk cases detected all cases of coeliac disease. The use of this decision tool may enable the endoscopist to target patients who need a duodenal biopsy.
F-18 FDG PET Demonstration of Sclerosing Mesenteritis
Authors: Ba D Nguyen
Journal: Clinical Nuclear Medicine (2003)

Sclerosing mesenteritis is a rare, combined inflammatory and fibrotic process of unknown etiology. Detailed cross-sectional imaging of this entity has been reported with computed tomography. The author presents an additional case of sclerosing mesenteritis demonstrated on fluorine-18 fluorodeoxyglucose positron emission tomography with multidetector computed tomographic correlation.
Acyclovir Suppresses Subclinical Shedding of Herpes Simplex Virus
Authors: Anna Wald
Journal: Annals of Internal Medicine (1996)

Letters1 November 1996Acyclovir Suppresses Subclinical Shedding of Herpes Simplex VirusAnna Wald, MD, MPH and Lawrence Corey, MDAnna Wald, MD, MPHUniversity of Washington Seattle, WA 98114.Search for more papers by this author and Lawrence Corey, MDUniversity of Washington Seattle, WA 98114.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-9-199611010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We greatly appreciate the information provided by Straus and colleagues [1], which confirms our observation [2] that acyclovir reduces asymptomatic HSV shedding in the genital region.We defined subclinical shedding as the detection of HSV from mucosal swabs without the presence of genital lesions; we believed that symptoms were insufficiently specific for the presence of viral shedding [3]. The women who participated in our study maintained a daily diary of genital symptoms (itching, burning, tingling, and pain). While receiving placebo, patients reported at least one genital symptom on 432 of 1754 days (24.6%). Herpes simplex virus type 2 ...References1. Straus SE, Seidlin M, Takiff HE, Rooney JF, Felser JM, Smith HA, et al. Effect of oral acyclovir treatment on symptomatic and asymptomatic virus shedding in recurrent genital herpes. Sex Transm Dis. 1989; 16:107-13. Google Scholar2. Wald A, Zeh J, Barnum G, Davis LG, Corey L. Suppression of subclinical shedding of herpes simplex virus type 2 with acyclovir. Ann Intern Med. 1996; 124(1 pt 1):8-15. Google Scholar3. Koutsky LA, Stevens CE, Holmes KK, Ashley RL, Kiviat NB, Critchlow CW, et al. Underdiagnosis of genital herpes by current clinical and viral isolation procedures. N Engl J Med. 1992; 326:1533-9. Google Scholar4. Sacks SL. Frequency and duration of patient-observed recurrent genital herpes simplex virus infection: characterization of the non-lesional prodrome. J Infect Dis. 1984; 150:873-7. Google Scholar5. Wald A, Zeh J, Selke S, Ashley RL, Corey L. Virologic characteristics of subclinical and symptomatic genital herpes infections. N Engl J Med. 1995; 333:770-5. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Washington Seattle, WA 98114. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGenital Herpes and PregnancyGENITAL HERPES COMPLICATING PREGNANCY 1 November 1996Volume 125, Issue 9Page: 776-777KeywordsAntiviral therapyGenital anatomyHerpes simplexLesionsPainPruritus Issue Published: 1 November 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Pseudoejection sound in hypertrophic subaortic stenosis: an echocardiographic correlative study.
Authors: K C Sze, P M Shah
Journal: Circulation (1976)

Phonoechocardiographic studies were performed in 23 patients with hypertrophic subaortic stenosis. In ten patients a distinct systolic sound was recorded, usually along the lower left sternal border. In eight of these cases the sound was low or medium frequency. Unlike the ejection click of valvular aortic stenosis, the sound began 40-100 msec after the upstroke of the indirect carotid pulse and occurred close to the initial peak of the carotid pulse. This sound, termed pseudoejection sound, was associated with systolic anterior movement (SAM) of the anterior mitral leaflet on the echocardiogram. In all six patients studied with simultaneous phonoechocardiograms, the pseudoejection sound coincided with the sudden halting of SAM of the anterior mitral leaflet. Following provocative maneuvers the sound became louder, and its timing, as well as the sharp halting of SAM of the mitral leaflet, occurred earlier in systole. The pseudoejection sound probably results either from impact of the anterior mitral leaflet against the interventricular septum or more likely from deceleration of blood flow in the left ventricular outflow tract. The echo data support the association of the pseudoejection sound with significant left aventricular outflow obstruction,
Novel technique for placement of overlapping self-expandable metal stents to close a massive pancreatitis-induced duodenal fistula
Authors: A. Rao, A. LeRoy, E. Bonin, S. Sweetser, T. Baron
Journal: Endoscopy (2012)

A 67-year-old man with infected pancreatic necrosis underwent serial endoscopic necrosectomies through a spontaneously formed massive duodenal fistula ([Fig. 1]). He also required percutaneous drainage of a communicating paracolic gutter collection.
Mutation causing congenital myasthenia reveals acetylcholine receptor β/δ subunit interaction essential for assembly
Authors: Polly A. Quiram, Kinji Ohno, Margherita Milone, Marc C. Patterson, Ned J. Pruitt, Joan M. Brengman, Steven M. Sine, Andrew G. Engel
Journal: Journal of Clinical Investigation (1999)

We describe a severe postsynaptic congenital myasthenic syndrome with marked endplate acetylcholine receptor (AChR) deficiency caused by 2 heteroallelic mutations in the β subunit gene. One mutation causes skipping of exon 8, truncating the β subunit before its M1 transmembrane domain, and abolishing surface expression of pentameric AChR. The other mutation, a 3-codon deletion (β426delEQE) in the long cytoplasmic loop between the M3 and M4 domains, curtails but does not abolish expression. By coexpressing β426delEQE with combinations of wild-type subunits in 293 HEK cells, we demonstrate that β426delEQE impairs AChR assembly by disrupting a specific interaction between β and δ subunits. Studies with related deletion and missense mutants indicate that secondary structure in this region of the β subunit is crucial for interaction with the δ subunit. The findings imply that the mutated residues are positioned at the interface between β and δ subunits and demonstrate contribution of this local region of the long cytoplasmic loop to AChR assembly.
Trastuzumab Reverses Letrozole Resistance and Amplifies the Sensitivity of Breast Cancer Cells to Estrogen
Authors: Gauri Sabnis, Adam Schayowitz, Olga Goloubeva, Luciana Macedo, Angela Brodie
Journal: Cancer Research (2009)

In this study, we investigated adaptive mechanisms associated with aromatase inhibitor (AI) resistance in breast cancer cells and show that sensitivity to AIs can be extended through dual inhibition of estrogen receptor (ER) and human epidermal receptor-2 (Her-2) signaling. We used human ER-positive breast cancer cells stably transfected with the aromatase gene (MCF-7Ca). These cells grow as tumors in nude mice and are inhibited by AIs. Despite continued treatment, tumors eventually become insensitive to AI letrozole. The cells isolated from these long-term letrozole-treated tumors (LTLT-Ca) were found to have decreased ERalpha levels. Our results suggest that LTLT-Ca cells survive estrogen deprivation by activation of Her-2/mitogen-activated protein kinase (MAPK) pathway. Here, we show that trastuzumab (antibody against Her-2; IC(50) = 0.4 mg/mL) was very effective in restoring the ERalpha levels and sensitivity of LTLT-Ca cells to endocrine therapy by down-regulation of Her-2/MAPK pathway and up-regulation of ERalpha. In contrast, trastuzumab was ineffective in the parental hormone-responsive MCF-7Ca cells (IC(50) = 4.28 mg/mL) and xenografts. By blocking Her-2, trastuzumab also up-regulates ERalpha and aromatase expression and hypersensitized MCF-7Ca cells to E(2). We show that trastuzumab is beneficial in hormone-refractory cells and xenografts by restoring ER, implicating Her-2 as a negative regulator of ERalpha. In xenograft studies, the combination of trastuzumab plus letrozole is equally effective in inhibiting growth of MCF-7Ca tumors as letrozole alone. However, on the acquisition of resistance and increased Her-2 expression, the combination of letrozole plus trastuzumab provided superior benefit over letrozole or trastuzumab alone.
ABC of clinical genetics. Gene structure and function.
Authors: H. M. Kingston
Journal: BMJ (1989)

The DNA molecule is fundamental to cell metabolism and cell division as well as providing the basis for inherited characteristics.Nucleic acid, initially called nuclein, was discovered by Friedrich Miescher in 1869, but it was not until 1953 that Watson and Crick produced their model for the double helical structure of DNA and proposed the mechanism for DNA replication.During the 1960s the genetic code was found to reside in the sequence of nucleotides comprising the DNA molecule, a group of three nucleotides coding for an amino acid.The rapid expansion of molecular techniques in the past decade has led to a better understanding of human genetic disease.The structure and function of many genes has been elucidated, and determining the nucleotide sequence of an entire gene is possible.The molecular pathology underlying various disorders is now defined, and DNA analysis can be used for investigating affected families.
Health: A Victim or Cause of Inflation?
Authors: Ronald Andersen
Journal: JAMA (1976)

This edited volume is based on a number of government-sponsored conferences on inflation in the health field that were held in 1974. Most of the authors are economists, although other disciplines such as law and political science are also represented. Why are the costs of medical care increasing more rapidly than the costs of most other goods and services? Reasons most often identified were expensive technological advances in medical science, restrictive laws and practices that have limited the entry of manpower into the field, reimbursement of hospitals on a cost basis, insurance coverage that reduces cost-consciousness on the part of the patient, and determination of the amount of services patients receive by physicians who are usually reimbursed on a fee for service basis. A second generic question considered is, what are the effects of rapid medical care cost increases on patients, providers of medical care, and the total economy of
S103 Anti-Pseudomonal Bacteriophage Cocktail Reduces Inflammatory Responses in the Murine Lung
Authors: R Pabary, C Singh, S Morales, A Bush, K Alshafi, D Bilton, EWFW Alton, A Smithyman, JC Davies
Journal: Thorax (2012)

Bacteriophages are naturally occurring viruses that specifically target and infect bacteria and, unlike antibiotics, are able to multiply at infection sites and adapt to resistant bacteria. We hypothesise that bacteriophage cocktails may be useful against <i>P. aeruginosa</i> (Pa) in cystic fibrosis and tested this in a murine infection model. Two strains of Pa were assessed: a) a clinical strain from an adult CF patient, b) a laboratory strain. Both strains were shown to be sensitive to a novel anti-Pseudomonal bacteriophage cocktail on a standard plaque assay. Adult BALB/c mice were inoculated intranasally with 50ul of Pa followed by 20ul of bacteriophage cocktail (treated, n=21) or SM buffer (control, n=21). Twelve mice were sacrificed at 24hrs after infection and the others at 48hr. Bronchoalveolar lavage was serially log diluted, cultured at 37<sup>o</sup>C and the remainder centrifuged and supernatant stored at –80<sup>o</sup>C for future analysis of soluble inflammatory markers. Total cell counts were determined using a haemocytometer. Non-quantitative splenic cultures were performed. <h3>Results</h3> All mice treated with bacteriophage (n=6) had cleared infection at 24hrs compared with none of the controls (n=6) (median [range] CFU/ml 0 [0–0] vs. 1305 [190–4700], p&lt;0.01); inflammatory cell counts did not differ. At the 48hr time point most mice had cleared the infection, with no phage-related differences. However, treated mice demonstrated significantly fewer inflammatory cells in BAL compared with controls (median [range] 4.50 [2.84–5.86] × 104/ml vs. 9.12 [6.93–13.86], p&lt;0.01 for the clinical strain; median [range] 6.04 [5.56–10.60] × 104/ml vs. 9.72 [8.56–15.28], p&lt;0.01 for the laboratory strain). Differential cell counts and measurements of soluble inflammatory mediators are underway. BALB/c mice successfully cle ared this dose of Pa by 48hrs, with an accompanying acute cellular inflammatory response. The reduction in cell number following co-administration of a bacteriophage cocktail to which the organisms were sensitive suggests that Pa was cleared earlier and more effectively in the phage-treated animals; this was confirmed by significant differences in bacterial load at the earlier, 24 hour time point. Further work is underway to explore the therapeutic potential of bacteriophage in pulmonary Pa infection.
Granulocyte colony-stimulating factor attenuates oxidative stress–induced apoptosis in vascular endothelial cells and exhibits functional and morphologic protective effect in oxygen-induced retinopathy
Authors: Hiroshi Kojima, Atsushi Otani, Akio Oishi, Yukiko Makiyama, Satoko Nakagawa, Nagahisa Yoshimura
Journal: Blood (2010)
Abstract 4531: Anticancer potential of curcurbitacin IIa trough STAT3/JAK2-independent, survivin and PARP mediated apoptosis and disruption of actin cytoskeleton
Authors: Qun Lu, Christi Boykin, Gen Zhang, Yan-Hua Chen, Ren-wei Zhang, XE Fan, Weimin Yang
Journal: Cancer Research (2010)

Abstract The medicinal plant Hemsleya amalils Diels has been used as a homeopathic treatment for various diseases in China for centuries and has recently been indicated as being effective in inhibiting cancer cell growth. To investigate the molecular mechanisms underlying the anti-cancer activity of Hemsleya family, we purified the active component curcurbitacin IIa. Curcurbitacin IIa inhibited cell growth, induced apoptosis in several cancer cell lines, and reduced tumor growth in vivo. Immunofluorescent light microscopy as well as time-lapse imaging demonstrated the remarkable clustering of filamentous actin and the increases in G2/M populations in cell cycle, indicating the disruption of mitosis as the potential mechanism of inducing apoptosis by curcurbitacin IIa. Flowcytometry confirmed increased cell death while western blots showed reduced phospho-histone H3 immunoreactivity, consistent with reduced mitosis. Cleavage of Poly (ADP-ribose) polymerase or PARP, immediate upstream of DNA breakdown as a result of caspase activation, was increased dramatically while AKT phosphorylation and the Inhibitor of Apoptosis Protein survivin expression were reduced. Prostate cancer cells stably transfected with oncoprotein δ-catenin in which survivin expression was increased showed reduced efficacy of curcurbitacin IIa to induce cell death. Combined with lack of its effects on STAT3/JAK2 phosphorylation, theses studies highlight curcurbitacin IIa as a new class of anti-cancer drugs in suppression of cancer cell expansion by disrupting the actin cytoskeleton and directing the cell to undergo apoptosis through inhibition of surviving, AKT, and PARP. Supported by Department of Defense (PC040569) and National Cancer Institute (CA111891). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4531.
EFFICACY OF STENT-SUPPORTED SUBINTIMAL ANGIOPLASTY IN ILIAC ARTERY OCCLUSIVE DISEASE.
Authors: Sanghoon Shin, Young-Guk Ko, Jung-Sun Kim, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Won-Heum Shim, Seung-Yun Cho
Journal: Journal of the American College of Cardiology (2010)
Diazepam for Cardioversion
Authors: A. Paul Naney
Journal: JAMA (1971)

<h3>To the Editor.—</h3> The conclusion and implication of arrhythmic hazard of diazepam described by Barrett and Hey ("Ventricular Arrhythmias Associated With the Use of Diazepam for Cardioversion,"<b>214:</b>1323, 1970) is not supported by the data presented. Each patient had evidence of myocardial disease, previous arrhythmias, and was receiving other drugs. In case 1, a short run of ventricular tachycardia appeared after a transthoracic capacitor discharge, an occurrence not infrequently reported and certainly more often with patients receiving digitalis. In case 2, premature ventricular contractions had occurred the previous day before any diazepam was given and this was not monitored in the interim before the second attempt at cardioversion. The arrhythmia displayed in the illustration is not ventricular fibrillation, as reported, but ventricular tachycardia, a progression from premature ventricular beats, that may fail to perfuse and produce the symptoms described. It was promptly cardioverted with no subsequent problems. Stopping digitalis
Three cases of porocarcinoma
Authors: Linda Puttick, P. INCE, J.S. Comaish
Journal: British Journal of Dermatology (1985)

Journal Article Three cases of porocarcinoma Get access Linda Puttick, Linda Puttick Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar P. INCE, P. INCE Department of Histopathology, Royal Victoria Infirmary, Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar J.S. Comaish J.S. Comaish Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Page 17, https://doi.org/10.1111/j.1365-2133.1985.tb12969.x Published: 01 July 1985
Affective brain-computer interfaces as enabling technology for responsive psychiatric stimulation
Authors: Alik S. Widge, Darin D. Dougherty, Chet T. Moritz
Journal: Brain-Computer Interfaces (2014)

There is a pressing clinical need for responsive neurostimulators, which sense a patient's brain activity and deliver targeted electrical stimulation to suppress unwanted symptoms. This is particularly true in psychiatric illness, where symptoms can fluctuate throughout the day. Affective BCIs, which decode emotional experience from neural activity, are a candidate control signal for responsive stimulators targeting the limbic circuit. Present affective decoders, however, cannot yet distinguish pathologic from healthy emotional extremes. Indiscriminate stimulus delivery would reduce quality of life and may be actively harmful. We argue that the key to overcoming this limitation is to specifically decode volition, in particular the patient's intention to experience emotional regulation. Those emotion-regulation signals already exist in prefrontal cortex (PFC), and could be extracted with relatively simple BCI algorithms. We describe preliminary data from an animal model of PFC-controlled limbic brain stimulation and discuss next steps for pre-clinical testing and possible translation.