Cytomegalovirus Thrombophlebitis After Successful DHPG Therapy
Authors: Powers Peterson, Celine M. Stahl-Bayliss
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 April 1987Cytomegalovirus Thrombophlebitis After Successful DHPG TherapyPOWERS PETERSON, M.D., CELINE M. STAHL-BAYLISS, M.D.POWERS PETERSON, M.D.Search for more papers by this author, CELINE M. STAHL-BAYLISS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-4-632 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Cytomegalovirus is a frequent cause of opportunistic infections in patients with the acquired immunodeficiency syndrome (AIDS) (1). 9-[1,3-dihydroxy-2-propoxy)methyl]guanine (DHPG) is a new, potent, and broadly active antiherpetic agent structurally similar to acyclovir. It was administered intravenously for 2 weeks to a male homosexual patient with persistent cytomegalovirus viremia. He was free of cytomegalovirus infection for 1 year and then developed a unique, previously unreported complication, cytomegalovirus thrombophlebitis.A 34-year-old white homosexual man was diagnosed with AIDS in November 1983, when Kaposi sarcoma was histologically confirmed. He remained well until November 1984, when he developed low-grade fevers, diffuse...References1. REICHERTO'LEARYLEVENSSIMRELLMACHER CTDCA. Autopsy pathology in the acquired immune deficiency syndrome. Am J Pathol. 1983;112:357-82. MedlineGoogle Scholar2. CHENGHUANGLIN YEJ. Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine against herpes virus type 1. Proc Natl Acad Sci USA. 1983;80:2767-70. CrossrefMedlineGoogle Scholar3. SHEPPDANDLIKERDE MIRANDA DRP. Activity of 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine in the treatment of cytomegalovirus pneumonia. Ann Intern Med. 1985;103:368-73. LinkGoogle Scholar4. LASKINSTAHL-BAYLISSKALMANROSECAN OCCL. Treatment with 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl] guanine for serious infections caused by cytomegalovirus in patients with the acquired immune deficiency syndrome. J Infect Dis. 1986.(In press.) Google Scholar5. DOUGLASCRITCHLOWBENEDETTI JCJ. A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection. N Engl J Med. 1984;310:1551-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCopper nanoparticles as inexpensive and efficient catalyst: A valuable contribution in organic synthesisEndocarditis and Intravascular InfectionsReview: Thromboses among HIV-Infected Patients during the Highly Active Antiretroviral Therapy EraAntiphospholipid syndrome associated with infections: clinical and microbiological characteristicsDeep vein thrombosis and acute cytomegalovirus infectionAIDS and Thrombosis: Retrospective Study of 131 HIV-Infected PatientsHIV and Thrombosis: A ReviewCytomegalovirus disease in AIDSAcquired protein S deficiency in children infected with human immunodeficiency virus 1 April 1987Volume 106, Issue 4Page: 632-633KeywordsAIDSCytomegalovirus infectionFeversHomosexualsKaposi sarcomaOpportunistic infectionsViremia Issue Published: 1 April 1987 PDF DownloadLoading ...