tbuckley/cabot-search huggingface dataset:
E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis
Authors: Karima R.R. Siddiqui, Sophie Laffont, Fiona Powrie
Journal: Immunity (2010)

Dendritic cells (DCs) play a pivotal role in controlling the balance between tolerance and immunity in the intestine. Gut conditioned CD103(+) DCs promote regulatory T (Treg) cell responses; however, little is known about DCs that drive inflammation in the intestine. Here, we show that monocyte-derived inflammatory DCs that express E-cadherin, the receptor for CD103, promote intestinal inflammation. E-cadherin(+) DCs accumulated in the inflamed mesenteric lymph nodes and colon, had high expression of toll-like receptors, and produced colitogenic cytokines, such as IL-6 and IL-23, after activation. Importantly, adoptive transfer of E-cadherin(+) DCs into T cell-restored immunodeficient hosts increased Th17 cell responses in the intestine and led to exacerbation of colitis. These results identify a monocyte-derived inflammatory DC subset that is associated with the pathogenesis of intestinal inflammation, providing a therapeutic target for the treatment of inflammatory bowel disease.
Hyponatraemia must be treated with low water input
Authors: B. Wilkins
Journal: BMJ (1996)

ent from the international non-proprietary name.On the other hand, the World Health Organisation cannot impose on these countries a name that they consider to be unacceptable.The most logical solution would be to set up bilateral discussions between the organisation's experts and the national nomenclature committees with a view to the adoption of a single non- proprietary name for those drugs for which discrepancies exist.
Effects of Recombinant Human Hyaluronidase (rHuPH20) on Subcutaneous Administration of 10% and 20% IgG in Yucatan Mini Pigs
Authors: W.H. Bee, T. Nekoroski, L. Zhang, D. Kang, W. Teschner, H.P. Schwarz, E.M. Muchitsch
Journal: Journal of Allergy and Clinical Immunology (2010)
Flecainide in the Treatment of Nonsustained Ventricular Tachycardia
Authors: Roop Lal, Peter D. Chapman, Gerald V. Naccarelli, Kenneth B. Schechtman, Robert L Rinkenberger, Paul J. Troup, Sung Soon Kim, Anne H. Dougherty, Rodolphe Ruffy
Journal: Annals of Internal Medicine (1986)

Thirty-two patients received flecainide acetate for nonsustained ventricular tachycardia after having had unsuccessful treatment with a mean of four antiarrhythmic drugs. The mean left ventricular ejection fraction was 41% in 27. Thirty-one patients had organic heart disease, and 22 patients had arrhythmia-related symptoms. Total suppression of ventricular tachycardia occurred in 22 patients. Thirty patients were discharged from the hospital receiving flecainide at a mean (+/- SD) dosage of 315 +/- 76 mg/d and 26 of these patients attained a mean trough plasma drug level of 567 +/- 254 ng/mL. One patient had proarrhythmia and 3 had worsening of heart failure. Twenty-two patients remained in the trial for a mean follow-up of 13 +/- 7 months. Five patients died (1 suddenly) during the follow-up period. Our data indicate that flecainide suppresses refractory nonsustained ventricular tachycardia in 69% of patients who have organic heart disease. Serious adverse effects were minimized by initiation of treatment in the hospital and careful surveillance of electrocardiograms and plasma drug levels.
Scientific Evidence and the Watts Riots
Authors: William J. Curran
Journal: New England Journal of Medicine (1969)

THE Court of Appeal in California has recently decided a very important case involving the acceptability in court of a new scientific test known as a "voiceprint." The technic consists of a spectrographic, stylus-traced recording of the voice of a person developed from a sound recording on tape. In The People v. King,1 the Court refused to allow a criminal conviction to stand based on personal identification as a result of a voiceprint. The Court held that the technic had not reached a sufficient level of scientific acceptability, particularly since it was still basically the theory and practice of . . .
Familial Scimitar Syndrome
Authors: Kinya Ashida, Akira Itoh, Takahiko Naruko, Masato Otsuka, Yuji Sakanoue, Makoto Kobayashi, Hajime Yamashita, Michitaka Nagashima, Takuro Shinsato, Syuichiro Takanashi, Yoshihiro Shimizu, Kazuo Haze
Journal: Circulation (2001)
CD3+/CD19+-depleted grafts in HLA-matched allogeneic peripheral blood stem cell transplantation lead to early NK cell cytolytic responses and reduced inhibitory activity of NKG2A
Authors: D N Eissens, N P M Schaap, F W M B Preijers, H Dolstra, B van Cranenbroek, A V M Schattenberg, I Joosten, A van der Meer
Journal: Leukemia (2009)
Relationships among ventricular arrhythmias, coronary artery disease, and angiographic and electrocardiographic indicators of myocardial fibrosis.
Authors: R M Califf, J M Burks, V S Behar, J R Margolis, G S Wagner
Journal: Circulation (1978)

This study was performed to determine the relationships among angiographic, hemodynamic, clinical, and electrocardiographic data and premature ventricular contractions (PVCs). Arrhythmias were analyzed by 24 hour Holter monitor in 244 patients evaluated for chest pain by coronary angiography and left ventriculography. Using a categorical linear model, the presence of myocardial fibrosis as indicated by both abnormal left ventricular contraction (LVC) and abnormal initial QRS on electrocardiogram was found to be the only independent predictor of both frequent and complex ventricular arrhythmias (P less than .0001). All other descriptors, including the number of diseased vessels (greater than or equal to 75% obstruction), were dependent upon abnormal LVC in their association with PVCs. When the right anterior oblique view of the left ventriculogram was divided into nine segments to allow automated quantiative analysis of LVC, the prevalence of frequent PVCs was directly related to the number of abnormally contracting segments. Of patients with 0 abnormal segments, 11% had greater than or equal to 2 PVC/hr, in contrast to 44%, 73% and 100% of patients with 1-3, 4-6, and 7-9 abnormal wall segments, respectively (P less than 0.01). A similar quantitative relationship was found between premature ventricular contractions and abnormal initial forces indicating previous myocardial infarction on the electrocardiogram.
Update in Hepatology
Authors: Willis C. Maddrey
Journal: Annals of Internal Medicine (2001)

Updates from the Annual Session6 February 2001Update in HepatologyWillis C. Maddrey, MDWillis C. Maddrey, MDFrom the University of Texas Southwestern Medical Center, Dallas, Texas.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-3-200102060-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Hepatology is an area in which research is under great pressure to meet emerging clinical challenges. The viral hepatitis epidemic has caused an influx of patients with symptomatic and asymptomatic liver disease into physicians' offices. Simultaneous developments in molecular biology have led to insights into viral pathogenesis and inherited metabolic diseases. The result has been a new era of promise in diagnosing and treating liver disease. This Update summarizes advances in hepatology over the past 2 years. I recount some important aspects of the history of viral hepatitis and hemochromatosis and describe notable new reports that may help guide an ... Author, Article, and Disclosure InformationAffiliations: From the University of Texas Southwestern Medical Center, Dallas, Texas.Corresponding Author: Willis C. Maddrey, MD, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLessons Learned about Barriers to Hepatitis C Testing: Implications for PolicySpecific relonic patterns from non‐specific or useless laboratory dataOxymatrine therapy for chronic hepatitis B: A randomized double-blind and placebo-controlled multi-center trial 6 February 2001Volume 134, Issue 3Page: 216-223KeywordsChronic hepatitis CCirrhosisHemochromatosisHepatitis AHepatitis BHepatitis CInterferonsLiverLiver diseasesVaccines ePublished: 6 February 2001 Issue Published: 6 February 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Ototoxic Drugs and Poor Renal Function
Authors: Gregory J. Matz
Journal: JAMA (1968)

<h3>To the Editor:—</h3> The ototoxicity of various antibiotics such as streptomycin, kanamycin, and neomycin seems well understood by the general medical community. However, less well recognized is the severe ototoxicity that can result when these drugs are used in low doses in the presence of impaired renal function. Our recent experience with a well-established ototoxic drug, kanamycin, and with a newly developed ototoxic drug, ethacrynic acid, may serve to illustrate this danger. Kanamycin's ototoxicity on a dose-related basis has been well established. However, the dose-related toxicity in the presence of poor renal function has not been established. Naunton and Ward,<sup>1</sup>Matz and Ward,<sup>2</sup>and Benitz et al<sup>3</sup>have all reported cases of profound sensorineural loss developing in patients with renal disease who received kanamycin. In Naunton's two cases low dosages were used, 14 gm in seven days and 5 gm in five days. Frost et al<sup>4</sup>
Heart block in mice overexpressing calcineurin but not NF-AT3
Authors: A GILLIS, K KAVANAGH, H MATHISON, J SOMERS, S ZHAN, H DUFF
Journal: Cardiovascular Research (2004)

Overexpression of calcineurin causes cardiac hypertrophy and arrhythmic deaths. During disease development, sinus bradycardia followed by high degree atrioventricular (AV) block finally culminating in ventricular asystole has been observed over time in calcineurin hearts. AV block is associated with the development of pleomorphic ventricular tachycardia in mice and downregulation of potassium currents in ventricular myocytes. We tested the hypothesis that the abnormalities of AV block and propensity to ventricular tachycardia relate to overexpression of calcineurin independent of the development of hypertrophy.Cardiac electrophysiologic properties were compared in isolated perfused hearts with ventricular hypertrophy due to overexpression of calcineurin or NF-AT3 and in their corresponding wild types at 15 or 30 days of age.Compared to wild-type hearts, significant prolongation of sinus node recovery times was noted in both NF-AT3 and calcineurin hearts. Compared to wild-type hearts, Wenckebach cycle length (WCL) and the left ventricular effective refractory period (LVERP) were significantly prolonged in the calcineurin hearts (p<0.05) but not NF-AT3 hearts. In calcineurin mice, left ventricular effective refractory period impinged on Wenckebach cycle length resulting in a significant correlation between left ventricular effective refractory period and Wenckebach cycle length (r(2)=0.56). No such correlation was observed for wild type or NF-AT3 hearts. At 30 days of development, ventricular tachycardia developed in 70% of calcineurin hearts compared to 0% wild-type hearts (p=0.003), whereas ventricular tachycardia was observed in 33% of NF-AT3 hearts and 10% of corresponding wild-type hearts (p=NS).The prolonged ventricular refractoriness, seen only in calcineurin hearts, impinges on Wenckebach cycle length resulting in heart block and is associated with propensity to ventricular tachycardia.
A Biblical Headache
Authors: Fred Rosner
Journal: JAMA (1976)

<h3>To the Editor. —</h3> Although I agree with Drs Horton and Bowman (234:1019, 1975) that the biblical incident of the Prophet Elisha reviving the child of the Shunamite woman (2 Kings 4:34-35) may represent a case of mouth-to-mouth resuscitation,<sup>1</sup>the suggestion that the boy's headache was due to a ruptured congenital intracranial aneurysm is pure speculation. Most biblical commentators interpret the child's illness (2 Kings 4:18-20) to have been sunstroke, since this was the boy's first exposure to the fiercely hot Middle Eastern sun.
Perioperative Dexmedetomidine Improves Outcomes of Cardiac Surgery
Authors: Fuhai Ji, Zhongmin Li, Hung Nguyen, Nilas Young, Pengcai Shi, Neal Fleming, Hong Liu
Journal: Circulation (2013)

Cardiac surgery is associated with a high risk of cardiovascular and other complications that translate into increased mortality and healthcare costs. This retrospective study was designed to determine whether the perioperative use of dexmedetomidine could reduce the incidence of complications and mortality after cardiac surgery. A total of 1134 patients who underwent coronary artery bypass surgery and coronary artery bypass surgery plus valvular or other procedures were included. Of them, 568 received intravenous dexmedetomidine infusion and 566 did not. Data were adjusted with propensity scores, and multivariate logistic regression was used. The primary outcomes measured included mortality and postoperative major adverse cardiocerebral events (stroke, coma, perioperative myocardial infarction, heart block, or cardiac arrest). Secondary outcomes included renal failure, sepsis, delirium, postoperative ventilation hours, length of hospital stay, and 30-day readmission. Dexmedetomidine use significantly reduced postoperative in-hospital (1.23% versus 4.59%; adjusted odds ratio, 0.34; 95% confidence interval, 0.192-0.614; P<0.0001), 30-day (1.76% versus 5.12%; adjusted odds ratio, 0.39; 95% confidence interval, 0.226-0.655; P<0.0001), and 1-year (3.17% versus 7.95%; adjusted odds ratio, 0.47; 95% confidence interval, 0.312-0.701; P=0.0002) mortality. Perioperative dexmedetomidine therapy also reduced the risk of overall complications (47.18% versus 54.06%; adjusted odds ratio, 0.80; 95% confidence interval, 0.68-0.96; P=0.0136) and delirium (5.46% versus 7.42%; adjusted odds ratio, 0.53; 95% confidence interval, 0.37-0.75; P=0.0030). Perioperative dexmedetomidine use was associated with a decrease in postoperative mortality up to 1 year and decreased incidence of postoperative complications and delirium in patients undergoing cardiac surgery. URL: www.clinicaltrials.gov. Unique identifier: NCT01683448.
WIDESPREAD ARTERIAL SPIDERS IN A CASE OF LATENT HEPATITIS, WITH RESOLUTION AFTER THERAPY*
Authors: D. A. WHITING, J. C. KALLMEYER, I. W. SIMSON
Journal: British Journal of Dermatology (1970)

SUMMARY.— A young woman developed widespread vascular spiders 9 months prior to admission. She was not pregnant and all tests of liver function were normal. A chronic hepatitis, possibly auto‐immune in origin, was diagnosed after a liver biopsy, and the hepatitis and the spiders cleared up after corticosteroid therapy. It is suggested that spiders may form in the blushing areas due to a loss of sphincter tone caused by impaired contractile cells in cutaneous arteriovenous shunts.
Abstract 2721: MEHD7945A, dual specific antibody against EGFR and HER3, augments radiation response in head and neck squamous cell carcinoma
Authors: Chunrong Li, Shyhmin Huang, Eric A. Armstrong, Mark X. Sliwkowski, Lukas C. Amler, Paul M. Harari
Journal: Cancer Research (2012)

Abstract The HER receptor family members (EGFR, HER2, HER3 and HER4) play an important role in tumorigenesis. High EGFR expression levels correlate with poor prognosis and resistance to therapy for many epithelial tumors. Combining EGFR inhibition with radiation has been extensively studied in head and neck squamous cell carcinoma (HNSCC). Increasing evidence implicates HER3 as a key mediator of response and resistance to EGFR targeted therapies. We therefore examined the capacity of a dual specific antibody MEHD7945A, that can simultaneously target EGFR and HER3, to modulate radiation response in HNSCC. We characterized 10 HNSCC cell lines for their EGFR and HER3 expression. Immunoblot analysis confirmed that MEHD7945A significantly inhibited basal and radiation-induced EGFR and HER3 phosphorylation and downstream MAPK and AKT signaling. MEHD7945A consistently inhibited tumor cell growth in culture ranging from 30∼80%. The growth inhibitory effect of MEHD7945A was more potent than that observed with anti-EGFR or anti-HER3 antibody alone. Using clonogenic survival assay, we found that MEHD7945A significantly enhanced radiosensitivity in HNSCC cells. Once again, this effect of MEHD7945A was more potent than that observed with anti-EGFR or anti-HER3 antibodies. Treatment with MEHD7945A and radiation induced cell cycle arrest in G1 and G2 phases. Tumor cells eventually processed to apoptosis without successful DNA damage repair, as reflected by increased apoptotic populations detected by AnnexinV/PI staining. In addition, an increase of nuclear γ-H2AX foci was observed in cells receiving combination MEHD7945A and radiation. We administered MEHD7945A systemically to athymic mice bearing human tumor xenografts. Using single dose and fractionated radiation schedules, we observed that combined MEHD7945A and radiation was significantly more potent than single modality treatment to induce HNSCC tumor growth inhibition. These in vitro and in vivo results indicate that MEHD7945A can sensitize cells to radiation and inhibit HNSCC tumor growth, suggesting the potential of MEHD7945A as a radiation sensitizer for future clinical investigations. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2721. doi:1538-7445.AM2012-2721
AIDS and Zinc Deficiency
Authors: Robert G. Weiner
Journal: JAMA (1984)

<h3>To the Editor.—</h3> Acquired immune deficiency syndrome (AIDS) is a complex disease. A multifactorial model is receiving strong support from investigators suggesting that the disease is a cumulative process following exposure to multiple injuries to the immune system. Furthermore, it is likely that all cases of AIDS are not from the same set of causes. I want to propose a new etiologic possibility for AIDS in homosexual men. In the past ten years, homosexuals have asserted a right to self-expression and there has been an outburst of pent-up feeling and an overactive sexuality. Many homosexuals have more than 60 partners per year,<sup>1</sup>a great preoccupation with sex, and an overactive use of masturbation, often with multiple ejaculations each day. The average volume of semen is 3 to 5 mL per ejaculation.<sup>2</sup>Semen is complex, with many proteins, enzymes, and prostaglandins, and is remarkable in the quantity of zinc
Chancellor allows only restricted freedom for foundation hospitals
Authors: N. Timmins
Journal: BMJ (2002)

Last week's settlement over the creation of foundation hospitals in England, the subject of a prolonged dispute between Gordon Brown, the chancellor, and the health secretary, Alan Milburn, might be described as a draw—if one was being charitable to Mr Milburn. But it is plain that the chancellor conceded little.

Mr Milburn got his desire for foundation hospitals to be created as independent, non-profit distributing, public interest companiesK—outside the NHS, in the sense that their assets will no longer be owned by the secretary of state.

These hospitals will also be able …
21 FUNCTIONAL RELEVANT TELOMERASE MUTATIONS ASSOCIATE WITH CIRRHOSIS FORMATION IN PATIENTS WITH CHRONIC LIVER DISEASE
Authors: D. Hartmann, U. Srivastava, M. Thaler, K. Kleinhans, R. Kratzer, K. Bauer, S.-F. Katz, Y. Begus-Nahrmann, G. von Figura, A. Lechel, C. Günes, G. N'Kontchou, A. Potthoff, K. Deterding, H. Wedemeyer, H. Schrezenmeier, M.P. Manns, M. Beaugrand, K.L. Rudolph
Journal: Journal of Hepatology (2010)
Collagen in the normal and hypertrophied human ventricle
Authors: P. G. CASPARI, M. NEWCOMB, K. GIBSON, P. HARRIS
Journal: Cardiovascular Research (1977)

Estimates of the collagen concentration in human ventricles have been made from measurements of the hydroxyproline concentration. In the normal heart the concentration of collagen was higher in the right ventricle than in the left ventricle. Age had no effect on the ventricular concentration of collagen. Hypertrophy in the absence of a valvar lesion was not associated with an increased concentration of collagen but, owing to the increased size of the ventricle, there was an increase in the estimated total mass of ventricular collagen. The concentration of collagen in the left ventricle of patients with aortic stenosis was higher than normal. Ventricular hypertrophy seems to be accompanied by an increase in the total mass of collagen whatever the cause. Whether the concentration changes or not depends on the proportion in which the mass of collagen increases relative to the mass of muscle cells.
Ethmoid Sinus Cancer
Authors: Norman M. Bleehen
Journal: JAMA (1972)

The ethmoid sinus is a collection of approximately nine air cells situated between the upper limit of the nasal fossa and the orbit and closely related to the posterio superior aspect of the maxillary antrum. Cancer in any of these regions may spread rapidly to the adjacent areas, especially as the early disease is frequently asymptomatic. Cancer involving the ethmoid sinus alone is therefore a rare entity, but is more usually part of an uncommon regional disease. A series of 715 tumors of the upper jaw collected by Lederman et al<sup>22</sup>over a period of 35 years included 176 cases of ethmoid cancer, ie, 25%. The basement membrane lining the sinus easily undergoes squamous metaplasia, and approximately 50% of the tumors are squamous cell carcinoma of varying degrees of differentiation, the majority of which are poorly differentiated. The remaining lesions include adenocarcinoma, lymphoma, Ringertz tumor, sarcoma, melanoma, and the
TCT-847 Safety And Efficacy Of Angio-Seal® Vs. Exo-Seal® In Patients Undergoing Primary Percutaneous Coronary Intervention For ST-elevation Myocardial Infarction
Authors: Natalia Pinilla, Ignacio Sanchez-Perez, Maria T. Lopez-Lluva, Alfonso Jurado-Roman, Manuel Marina-Breysse, Jesus Piqueras-Flores, Pilar Agudo-Quilez, Fernando Lozano
Journal: Journal of the American College of Cardiology (2014)
Group G streptococcal pharyngitis. Analysis of an outbreak at a college
Authors: J. D. McCue
Journal: JAMA (1982)

Sixty-eight patients with group G β-hemolytic streptococcal pharyngitis were treated at a student health service during a nine-day period. The illness, probably spread among students by respiratory droplet, was indistinguishable from adult group A streptococcal pharyngitis, with a majority of students having exudate, fever, and adenitis. Poor compliance with antibiotic treatment was associated with elevated antistreptolysin o titers and persistently positive throat culture results. Treatment did not affect overall duration of symptomatic illness. (<i>JAMA</i>1982;248:1333-1336)