tbuckley/cabot-search huggingface dataset:
The effect of a multifaceted empowerment strategy on decision making about the number of embryos transferred in in vitro fertilisation: randomised controlled trial
Authors: A. van Peperstraten, W. Nelen, R. Grol, G. Zielhuis, E. Adang, P. Stalmeier, R. Hermens, J. Kremer
Journal: BMJ (2010)

<b>Objective</b> To evaluate the effects of a multifaceted empowerment strategy on the actual use of single embryo transfer after in vitro fertilisation. <b>Design</b> Randomised controlled trial. <b>Setting</b> Five in vitro fertilisation clinics in the Netherlands. <b>Participants</b> 308 couples (women aged &lt;40) on the waiting list for a first in vitro fertilisation cycle. <b>Interventions</b> The multifaceted strategy aimed to empower couples in deciding how many embryos should be transferred. The strategy consisted of a decision aid, support of a nurse specialising in in vitro fertilisation, and the offer of reimbursement by way of an extra treatment cycle. The control group received standard care for in vitro fertilisation. <b>Main outcome measures</b> Use of single embryo transfer in the first and second treatment cycles as well as decision making variables and costs of the empowerment strategy. <b>Results</b> After the first treatment cycle, single embryo transfer was used by 43% (65/152) of couples in the intervention group and 32% (50/156) in the control group (difference 11%, 95% confidence interval 0% to 22%; P=0.05). After the second treatment cycle, single embryo transfer was used by 26% (14/154) of couples in the intervention group compared with 16% (8/51) in the control group (difference 10%, −6% to 26%; P=0.20). Compared with couples receiving standard care, those receiving the empowerment strategy had significantly higher empowerment and knowledge levels but no differences in anxiety levels. Mean total savings per couple in the intervention group were calculated to be €169.75 (£146.77; $219.12). <b>Conclusions</b> A multifaceted empowerment strategy encouraged use of single embryo transfer, increased patients' knowledge, reduced costs, and had no effect on levels of anxiety or depression. This strategy could therefore be an important tool to reduce the twin pregnancy rate after in vitro fertilisation. This trial did not, however, demonstrate the anticipated 25% difference in use of single embryo transfer of the power calculation. <b>Trial registration</b> ClinicalTrials.gov NCT00315029.
Trade names or proper names? A problem for the prescriber.
Authors: E C Huskisson
Journal: BMJ (1973)

team at least once weekly to review the patients' progress.To be dynamic a day hospital must be continually discharging and accepting new patients and there should never be a waiting list.It is a great advantage if there are clear pathways between the day hospital and the various social day care facilities so that those who no longer need the therapeutic aspect of day care may continue to enjoy its social benefit. ADVANTAGESThe advantages of the geriatric day hospital lie first in allowing the treatment of many elderly people without hospital admission,
Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome
Authors: Heleen H Arts, Dan Doherty, Sylvia E C van Beersum, Melissa A Parisi, Stef J F Letteboer, Nicholas T Gorden, Theo A Peters, Tina Märker, Krysta Voesenek, Aileen Kartono, Hamit Ozyurek, Federico M Farin, Hester Y Kroes, Uwe Wolfrum, Han G Brunner, Frans P M Cremers, Ian A Glass, Nine V A M Knoers, Ronald Roepman
Journal: Nature Genetics (2007)
Transcription factor RORα is critical for nuocyte development
Authors: See Heng Wong, Jennifer A Walker, Helen E Jolin, Lesley F Drynan, Emily Hams, Ana Camelo, Jillian L Barlow, Daniel R Neill, Veera Panova, Ute Koch, Freddy Radtke, Clare S Hardman, You Yi Hwang, Padraic G Fallon, Andrew N J McKenzie
Journal: Nature Immunology (2012)
STUDIES ON THE Cx-REACTIVE PROTEIN
Authors: Harrison F. Wood, Sonia Anderle, Carolyn W. Hammond, C. Phillip Miller
Journal: The Journal of Experimental Medicine (1960)

Young adult rabbits (2 to 3 kg.) were subjected to a single total body exposure of x-radiation ranging from 50 to 1200 r and tested frequently for the presence of Cx-reactive protein in their blood. It usually appeared in two phases separated by an interval of several days. The primary phase occurred 24 to 48 hours after irradiation in almost all (92 of 97) rabbits exposed to 500 r or more and in 4 of 16 exposed to 300 r or less. The secondary phase occurred during the 2nd week in many of the rabbits irradiated with 900 r or more and in a few irradiated with 700 r. Autopsy cultures failed to demonstrate the presence of infection in rabbits which died or were sacrificed during the primary phase. Bacterial infection was demonstrated, however, in almost all (21 of 24) rabbits autopsied and cultured during the secondary phase. After the disappearance of the primary phase in rabbits exposed to 700 or 900 r, the secondary phase could be elicited by initiating bacterial infection. Within 6 to 24 hours after intravenous inoculation of E. coli, Cx-reactive protein reappeared in the blood and persisted until death or termination of the experiment. Reappearance of the protein also followed the intravenous injection of killed E. coli but it disappeared again 1 to 2 days later. The results indicate that the primary phase is elicited by radiation injury per se and the secondary phase by bacterial infection.
THE HYGIENIC AND SCIENTIFIC VALUE OF EXAMINATIONS OF THE EYES AND EARS OF SCHOOL CHILDREN.
Authors: B. ALEX. RANDALL
Journal: JAMA (1895)

Much work has been done in the last half century for the improvement of the hygiene of the school, with the result of formulating with much precision the best arrangement of the school building as regards site, plan, ventilation and illumination, and much of this is continually being put into practice with ever-growing advance in these matters of the school surroundings. The parallel and equally important field of educational methods has also been well worked by the pedagogues and others in response to the protest as to overburdened pupils; and while the standards of requirement have advanced and educational forcing has continued unabated, it is probable that the resulting damage has been materially lessened. More sweeping application of the rules generally accepted as requisite, is alone needful to place this aspect of the matter in fairly satisfactory shape. Forced into rather wholesale dealing with their scholars by large classes and
Anti-selectin therapy against hepatic ischemia-reperfusion injury
Authors: Hartmut Jaeschke
Journal: Hepatology (2003)

Evidence shows that leukocyte recruitment into inflamed liver sinusoids does not require selectins, with one notable exception: ischemia-reperfusion (I/R). We used intravital microscopy to directly visualize the liver microcirculation during I/R and localized endotoxemia (liver superfused with lipopolysaccharide). General anti-selectin therapy (fucoidan) or anti-adhesion therapy with an antithrombin inhibitor (hirudin) was also used. Many neutrophils rolled and adhered in postsinusoidal vessels and sequestered in the sinusoids during I/R and local endotoxin superfusion. Although fucoidan blocked rolling in both forms of inflammation, leukocyte recruitment into sinusoids was only blocked in I/R. Adhesion was also inhibited in postischemic sinusoids with a second anti-adhesive agent (hirudin). Because liver I/R inevitably induces ischemia upstream in the intestine, anti-selectin therapy may prevent intestinal injury, which could prevent downstream liver inflammation. To test this hypothesis, we completely removed the intestine and rerouted blood flow from the superior mesenteric artery to the superior mesenteric vein. I/R was induced in the liver microcirculation, and many leukocytes rolled and adhered in postsinusoidal venules and adhered in sinusoids. Although fucoidan significantly reduced the rolling in postsinusoidal vessels, adhesion persisted in the sinusoids. Our data suggest that anti-adhesion therapy is effective in liver I/R in the sinusoids and postsinusoidal venules, perhaps in part due to its beneficial effect on the intestine.
Endoscopic ultrasonography in esophageal tuberculosis
Authors: X.-M. Han, J.-M. Yang, L.-H. Xu, L.-M. Nie, Z.-S. Zhao
Journal: Endoscopy (2008)

Esophageal tuberculosis is so rarely seen that it is difficult to identify by conventional endoscopy and computed tomography (CT), and is frequently misdiagnosed and inappropriately treated. To date, endoscopic ultrasonography (EUS) in the context of esophageal tuberculosis has only been sketchily described in a few case reports. In the present report we summarize and analyze four cases with regard to the EUS features of the lesions of esophageal tuberculosis. These features included heterogeneous or homogeneous hypoechoic masses in the esophageal wall, incrassation, interruption of esophageal adventitia, and mediastinal lymphadenitis. Most of the masses in the esophageal wall had hyperechoic spots and strips in the parenchyma. The esophageal lesions usually involved or had conglutinated with the enlarged mediastinal lymph nodes.
A selective culture system for generating terminal deoxynucleotidyl transferase-positive (TdT+) lymphoid precursor cells in vitro. I. Description of the culture system.
Authors: J Hayashi, E S Medlock, I Goldschneider
Journal: The Journal of Experimental Medicine (1984)

A primary xenogeneic culture system has been devised that selectively generates undifferentiated TdT+ lymphoblasts from rat bone marrow under conditions that do not support the growth or maintenance of rat colony-forming unit-spleen (CFU-S) or granulocyte/macrophage colony-forming cells (GM-CFC). The culture system requires a mouse bone marrow feeder layer, and a serum supplement that has markedly reduced levels of cortisol. The growth of TdT+ cells can be significantly enhanced by the addition of mesodermalizing factors (e.g., fibroblast growth factor, guinea pig bone marrow extract) to the culture medium, and the serum supplement can be decreased by the addition of selenium, transferrin, and T3. The cultured TdT+ cells are antigenically "null" cells that further resemble their normal counterparts in bone marrow with respect to morphology, size, cortisone sensitivity, and pattern of TdT fluorescence. The TdT+ cells are generated with equal facility from bone marrow of normal and congenitally athymic rats, can be maintained in logarithmic growth for at least 10 mos by serial passage in vitro, and do not cause leukemia when infused into irradiated recipients. Although the lineage relationships of these immature lymphoid cells have not yet been established, our working hypothesis, based on preliminary evidence, is that the cultured TdT+ cells are primitive members of the T cell series.
Prognostic and oncogenic relevance of TLX1/HOX11 expression level in T-ALLs
Authors: Julie Bergeron, Emmanuelle Clappier, Isabelle Radford, Agnès Buzyn, Corinne Millien, Gwendoline Soler, Paola Ballerini, Xavier Thomas, Jean Soulier, Hervé Dombret, Elizabeth A. Macintyre, Vahid Asnafi
Journal: Blood (2007)
Significance of the HV interval in 517 patients with chronic bifascicular block.
Authors: R C Dhingra, E Palileo, B Strasberg, S Swiryn, R A Bauernfeind, C R Wyndham, K M Rosen
Journal: Circulation (1981)

In January 1975, we reported results of a prospective follow-up study (mean 538 +/- 42 days) of 119 patients with chronic bifascicular block (BFB), and concluded that BFB patients with normal and prolonged HV (NHV and PHV) had a similar incidence of atrioventricular (AV) block and mortality. In this report, we update these findings in 517 patients with a follow-up of 21 days to 9.8 years (mean 3.4 +/- 0.2 years). Three hundred nineteen patients (61%) had NHV and 198 (39%) had PHV (greater than 55 msec). The NHV and PHV groups were similar in regard to age (NHV vs PHV, 61 +/- 1 vs 62 +/- 1 years) and sex (80% male, 20% female vs 82% male and 18% female). The following were more common (p less than 0.05) in patients with PHV (percent of patients with finding in NHV vs PHV groups): angina (18% vs 27%), congestive failure (27% vs 42%), cardiomegaly (48% vs 66%), New York Heart Association functional class II-IV (34% vs 56%), premature ventricular complexes (20% vs 29%), and organic heart disease (OHD) (75% vs 85%). Spontaneous trifascicular block (TFB) developed in two patients (0.6%) with NHV and nine patients (4.5%) with PHV (p less than 0.05). Cumulative 7-year incidence of TFB was 3% with NHV and 12% with PHV (p less than 0.01). Seven-year cumulative cardiovascular mortality was 32% in NHV patients and 57% in PHV patients (p less than 0.005). In conclusion, PHV in patients with chronic BFB was associated with a greater incidence and severity of OHD, and higher total and sudden death mortalities. The risk of spontaneous TFB was small in patients with either NHV or PHV, although it was significantly higher in the latter.
Fatal multisystemic toxicity associated with prophylaxis with pyrimethamine and sulfadoxine (Fansidar).
Authors: C D Selby, E J Ladusans, P G Smith
Journal: BMJ (1985)

Does potassium lower blood pressure by increasing sodium excretion?A metabolic study in patients with mild to moderate essential hvpertension. CommentBy studying a small sample of patients we have established that Cryptosporidium exists in Bangladesh.As the sole pathogen it seems to cause a mild, transient, easily managed form of diarrhoea, particularly among young children; only four (16%O,) of the 25 patients studied were malnourished.The presence of cough in some of the on 19 August 2023 by guest.
In praise of secular Bayesianism
Authors: Evan Heit, Shanna Erickson
Journal: Behavioral and Brain Sciences (2011)

Abstract It is timely to assess Bayesian models, but Bayesianism is not a religion. Bayesian modeling is typically used as a tool to explain human data. Bayesian models are sometimes equivalent to other models, but have the advantage of explicitly integrating prior hypotheses with new observations. Any lack of representational or neural assumptions may be an advantage rather than a disadvantage.
PTH-011 Polypectomy May Lead to Inadequate Surveillance of Patients with a Family History of Colorectal Cancer
Authors: P G Vaughan-Shaw, N R Borley, I P Tomlinson, J M Wheeler
Journal: Gut (2013)

<h3>Introduction</h3> Surveillance colonoscopy and polypectomy in those with a family history of colorectal cancer (CRC) may prevent malignant transformation of adenomatous polyps yet would then attenuate the apparent strength of familial aggregation. This study compares UK and US surveillance recommendations and considers the effect of polypectomy on family history. <h3>Methods</h3> We performed a ‘proof of principle’ study of patients undergoing colonoscopy for ‘family history’ and polypectomy for large adenomas (= &gt; 1cm) at our trust over an 18-month period. UK and US Surveillance recommendations for a hypothetical first degree relative (FDR) of each patient were calculated. Surveillance recommendations for FDRs were re-calculated assuming that polypectomy had not been performed in our patients and CRC had developed. <h3>Results</h3> 14 patients were included with median age 50 years. UK guidelines recommended no screening or once-off colonoscopy for 9/14 FDRs of our sample, while US guidelines recommended at least 5 yearly colonoscopy for all FDRs. The <i>hypothetical</i> development of<i> CRC</i> in our patients resulted in increased surveillance recommendations for 12/14 hypothetical FDRs under UK guidelines but for only 3/14 FDRs under US guidelines. <h3>Conclusion</h3> In those with a family history of CRC, surveillance colonoscopy and polypectomy may attenuate the apparent level of risk to those patients’ first degree relatives. US guidelines, which consider CRC and advanced adenomatous polyps as equal familial risk factors, recommend more aggressive surveillance in the kindred of our study sample, yet may be considered excessive. Under UK guidelines CRC risk may be underestimated and recommended surveillance inadequate. <h3>Disclosure of Interest</h3> None Declared.
Thrombin-sensitive dual fluorescence imaging and therapeutic agent for detection and treatment of synovial inflammation in murine rheumatoid arthritis
Authors: Doris Gabriel, Norbert Lange, Veronique Chobaz-Peclat, Maria Fernanda Zuluaga, Robert Gurny, Hubert van den Bergh, Nathalie Busso
Journal: Journal of Controlled Release (2012)
Pulmonary ischaemia-reperfusion injury: role of apoptosis
Authors: C. S. H. Ng, S. Wan, A. P. C. Yim
Journal: European Respiratory Journal (2005)

The central role of lung ischaemia–reperfusion injury in pulmonary dysfunction after cardiac surgery, particularly thoracic organ transplantation, has been well recognised. Lung tissue necrosis after prolonged ischaemia is known to worsen lung function, which was believed to be due largely to adjacent tissue inflammation. Recent studies suggest that lung apoptosis following ischaemia–reperfusion could be equally important in the development of post-operative lung dysfunction. The current literature on the mechanism and pathways involved in pulmonary dysfunction and, in particular, its relationship with apoptosis after lung ischaemia–reperfusion is briefly reviewed here. A better understanding of lung apoptosis, as well as the upstream pathways, may help in the development of therapeutic strategies that could benefit patients undergoing cardiac and lung transplantation.
Bowenoid transformation of seborrhoeic verrucae (keratoses)
Authors: HOMAYOON RAHBARI
Journal: British Journal of Dermatology (1979)

Seborrhoeic verrucae (keratoses) are considered to be benign lesions. Occasional bowenoid transformation of these benign growths has not been widely recognized. Seven cases of seborrhoeic verrucae with bowenoid transformations are presented to alert the clinician and the pathologist to this occurrence.
Case 48-1978
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Robert H. McLean, David L. Gang
Journal: New England Journal of Medicine (1978)

Presentation of CaseA nine-year-old girl was admitted to the hospital because of progressive renal failure.She was born of the sixth pregnancy in a mother aged 35 years. Parturition was complicated by persistent nausea and vomiting, but labor was normal. The birth weight was 2.65 kg. An unexpected twin brother was born after the patient, with a birth weight of 2.2 kg. The brother's growth, development and milestones were normal.At the age of 19 months the patient was taken to another hospital because of a urinary-tract infection. The urea nitrogen was 17 mg, and the creatinine 0.6 mg . . .
Lois Edythe Hurter
Authors: D. Hurter
Journal: BMJ (2014)

Lois Edythe Hurter was the third daughter of Herbert Hurter, an eminent general medical practitioner in Liverpool. After schooling at Belvedere High School for girls in Liverpool and Cheltenham Ladies College, where she was head girl, she went to the Royal Free Hospital School of Medicine for Women. Its preclinical school was moved to Aberdeen …
The Tell-Tale Beeper
Authors: Clyde Partin
Journal: Annals of Internal Medicine (2003)

On Being a Doctor19 August 2003The Tell-Tale BeeperClyde Partin, MDClyde Partin, MDFrom Emory University School of Medicine, Atlanta, GA 30322.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-4-200308190-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail That call to danger, like a doctor's beeper shocking the orderly solitude and safety of the squash court.John Irving, Trying to Save Piggy SneedThe institution of marriage has been my pleasure for 17 years, but the beeper has been my mistress longer. I have experienced, even benefited from, the evolution of the beeper during those years. The introduction of the cell phone further enhanced my life, allowing me to stay on the sidelines of a little league soccer game while I answered a page instead of driving around to find a pay phone hungry for my quarters.Older physicians ... Author, Article, and Disclosure InformationAffiliations: From Emory University School of Medicine, Atlanta, GA 30322.Acknowledgments: The author thanks Ms. Terry Repak for editorial advice.Corresponding Author: Clyde Partin, MD, Emory University School of Medicine, 1525 Clifton Road, 3rd Floor, Atlanta, GA 30322; e-mail, [email protected]org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 August 2003Volume 139, Issue 4Page: 299-300KeywordsEmergency departmentMemoryNursesResidencySafetySkullSleepSurgeonsTestosteroneTouch ePublished: 19 August 2003 Issue Published: 19 August 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
649. Increased Therapeutic Efficacy of the Prostate-Specific Oncolytic Adenovirus Ad[I/PPT-E1A] by Introduction of the Entire E3 Region or the Adenovirus Death Protein
Authors: Angelika Danielsson, Helena Dzojic, Berith Nilsson, Wing-Shing Cheng, Magnus Essand
Journal: Molecular Therapy (2006)

Conditionally replicating adenoviruses are developing as a complement to traditional cancer therapies. Ad[I/PPT-E1A] is a virus that replicates exclusively in prostate cells since the expression of E1A is controlled by the tissue specific promoter PPT. The regulatory PPT sequence is composed of a PSA enhancer, a PSMA enhancer and a TARP promoter. The H19 insulator (I) placed in front of PPT protects the regulatory sequence from interfering signals from the adenoviral backbone that otherwise can make the expression unspecific. This virus has now been improved by including only the active part of the H19 insulator and by adding either the entire adenoviral E3 region (Ad[iPPT-E1A, E3]) or just ADP (Ad[iPPT- E1A, ADP]). Since proteins expressed by the E3 region play a crucial role in blocking immune responses from the host, theseproteins are important for the persistence of the viral infection. ADP, which is located in the E3 region, is important for efficient viral release. These two viruses have been compared to Ad[I/PPT- E1A] and results from in vitro studies demonstrate a more efficient cell kill without altered specificity. The Ad[iPPT-E1A, E3] vector has also been evaluated in vivo by intratumoral injection of the virus in subcutaneous LNCaP tumors on nude mice. Treated mice showed tumor suppression compared to the control group. Ad[iPPT-E1A, E3] and Ad[iPPT-E1A, ADP] will be further investigated but so far both of them seem promising for use in the clinic.
Open to Control — New Hope for Patients with Neonatal Diabetes
Authors: Fiona M. Gribble, Frank Reimann
Journal: New England Journal of Medicine (2004)

Pancreatic beta cells, the insulin-releasing cells of the islets of Langerhans, are electrically excitable cells. They sense fluctuations in the plasma glucose concentration and convert the signal into a change in electrical activity that modulates insulin secretion. Mutations affecting the molecular machinery underlying this conversion are prime suspects in the causation of diabetes mellitus, in which an increase in the plasma glucose level is not adequately matched by increased insulin secretion. At the heart of the mechanism that changes the metabolic signal into an electrical one lies the ATP-sensitive potassium channel (KATP channel); polymorphisms in this channel have recently . . .