Scientific Methodology in Clinical Medicine
Authors: ALVAN R. FEINSTEIN
Journal: Annals of Internal Medicine (1964)

Special Article1 November 1964Scientific Methodology in Clinical MedicineIII. The Evaluation of Therapeutic ResponseALVAN R. FEINSTEIN, M.D.ALVAN R. FEINSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-5-944 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe following paper is the third of four parts of Dr. Feinstein's cogent analysis of scientific methodology in clinical medicine. The last part, which will appear in the December issue of the ANNALS, is entitled "IV. Acquisition of Clinical Data."—Ed.OUTLINE OF CONTENTS: PART IIITHE TARGETS OF TREATMENTPREVENTION OF DISEASE AND OF CLINICAL MANIFESTATIONSDiseaseClinical ManifestationsALTERATION OF DISEASE AND OF CLINICAL MANIFESTATIONSDiseaseClinical ManifestationsINDEXES AND CRITERIA OF THERAPEUTIC RESPONSEVERBAL AND MEASURED PRECISION IN CLINICAL DESCRIPTIONESTABLISHMENT OF INDEXES AND CRITERIAUTILIZATION OF MEDICAL RECORDSRETROSPECTIONQUALITYSUMMARYThe care of a sick person...References1. FEINSTEIN AR: Scientific methodology in clinical medicine I. Introduction, principles, and concepts. Ann. Intern. Med. 61: 564-579, 1964. LinkGoogle Scholar2. FEINSTEIN AR: Scientific methodology in clinical medicine. II. Classification of human disease by clinical behavior. Ann. Intern. Med. 61: 757, 1964. LinkGoogle Scholar3. CALKINSBLACKCLARKHOLLANDERMAINLANDMIKKELSENRAGANSHORT ERLGMJLDWMCCL: Therapeutic evaluation in rheumatoid arthritis. Arthritis Rheum. 3: 101-111, 1960. CrossrefGoogle Scholar4. FEINSTEINWOODSPAGNUOLOTARANTAJONASKLEINBERGTURSKY ARHFMASEE: Rheumatic fever in children and adolescents: A long term epidemiologic study of subsequent prophylaxis, streptococcal infections, and clinical sequelae. VII. Cardiac changes and sequelae. Ann. Intern Med. 60 (Supplement 5): 87-123, 1964. LinkGoogle Scholar5. FEINSTEINAREVALO ARAC: Manifestations and treatment of congestive heart failure in young patients with rheumatic heart disease. Pediatrics, 33: 666-671, 1964. Google Scholar6. SHAPIROWEINBLATTFRANKSAGERDENSEN SECWRVPM: The H.I.P. study of incidence and prognosis of coronary heart disease: Methodology. J. Chron. Dis. 16: 1281-1292, 1963. CrossrefMedlineGoogle Scholar7. FRANKWEINBLATTSHAPIROSEIDENSAGER CWESGERV: The H.I.P. study of incidence and prognosis of coronary heart disease: Criteria for diagnosis. J. Chron. Dis. 16: 1293-1312, 1963. CrossrefMedlineGoogle Scholar8. Working party on the evaluation of different methods of therapy in leukaemia. First report to the medical research council. Treatment of acute leukaemia in adults: Comparison of steroid therapy at high and low dosage in conjunction with 6-Mercaptopurine. Brit. Med. J. #5322: 7-14 (Jan. 5), 1963. Google Scholar9. KORSTFRENKELNIXON DREPJC: Multiple myeloma. Studies of mouse plasma cell tumor and human myeloma responsiveness to cyclophosphamide (Cytoxan). Ann. Intern. Med. 60: 217-230, 1964. [cf. Appendix, p. 230]. LinkGoogle Scholar10. CROOKSWAYNEROBB JEJRA: A clinical method of assessing the results of therapy in thyrotoxicosis. Lancet I: 397-401, 1960. CrossrefGoogle Scholar11. MAHER-LOUGHNANMACDONALDMASONFRY GPNAAL Controlled trial of hypnosis in the symptomatic treatment of asthma. Brit. Med. J. #5301: 371-375, 1962. CrossrefMedlineGoogle Scholar12. FEINSTEIN AR Scientific methodology in clinical medicine. IV. Acquisition of clinical data. Ann. Intern. Med. 61: In press. 1964. LinkGoogle Scholar13. HILL AB The clinical trial. Brit. Med. Bull. 7: 278-282, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALVAN R. FEINSTEIN, M.D.Affiliations: New Haven, ConnecticutFrom the Department of Medicine (Clinical Biostatistics Section), Veterans Administration Hospital, West Haven, Conn., and the Department of Medicine, Yale University School of Medicine, New Haven, Conn.The work described here was conceived and prepared during investigations supported by grant CAO7155 from the National Cancer Institute, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Alvan R. Feinstein, M.D., Associate Professor of Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, Conn. 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Part II: EthologyA Short History of Evidence-Based MedicineOn statistical testing of prevalence studiesSymptoms as an Index of Biological Behaviour and Prognosis in Human Cancer 1 November 1964Volume 61, Issue 5_Part_1Page: 944-965KeywordsBiostatisticsData acquisitionEpidemiologyHealth care qualityHospital medicineLesionsMedical services ePublished: 1 December 2008 Issue Published: 1 November 1964 PDF downloadLoading ...