tbuckley/cabot-search huggingface dataset:
Abstract 5503: Dual fluorescence high throughput screen detects MUC16 selective therapeutic candidates
Authors: Dharmarao Thapi, Guillaume Normand, Irena D. Ivnitski-Steele, Irina Ostrovnaya, David Shum, David R. Spriggs, Hakim Djaballah
Journal: Cancer Research (2010)

Abstract BACKGROUND: The MUC16 gene encodes the CA125 ovarian cancer antigen. This glycoprotein is expressed in the majority of Epithelial Ovarian Cancers (EOC) but has limited expression elsewhere in the adult human. Expression of the carboxy-portion of MUC16 results in increased invasion, soft agar growth and in vivo growth. OBJECTIVES: We sought to develop a suitable microscopy based assay system to screen for and identify small molecules which have a differential effects against MUC16+ cells compared to the isogenic MUC16 negative ovarian cancer cell lines. Using this assay we seek to identify MUC16 specific small molecules for development of potential chemotherapy drug candidates against ovarian cancer. METHODS: Carboxy-terminus portions of the Human MUC16 gene were introduced into SK-Ov-3 and A2780 EOC cell lines and labeled with the red fluorescent protein (mCherry) vector. Control lines were labeled with green fluorescent protein (GFP) vector. Relative toxicity of tested compounds on MUC16+ (mCherry) and MUC16- (GFP) cell populations was assessed by cell viability using ratiometric fluorescence intensities of both co-cultured isogenic cells. Compounds with differential activity were selected, resupplied and tested in a 96 well plate viability assay for confirmation. RESULTS: Both A2780 and SK-Ov-3 isogenic pairs had similar in vitro growth characteristics. A small scale pilot screen of 3,119 compounds was completed for each pair of isogenic cells. Six compounds, including Quinacrine, Ellipticine and Acriflavinium were relatively selective for MUC16+ A2780 cells and these three compounds were among the hits identified in the secondary SK-Ov-3 dual fluorescence screen. Caspase3 apoptosis assay was used to confirm Quinacrine as the most selective inhibitor in the MUC16+ cells. CONCLUSIONS: MUC16 +/− dual fluorescence screen is an example of a high throughput screening strategy to identify potentially specific modulators of key oncogenic targets. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5503.
Aerobic capacity and oxygen debt related to canoe racing performance
Authors: G. E. Cooper
Journal: British Journal of Sports Medicine (1982)

remained relatively constant.Wide variations in white cell count were observed during the study in both the swimmers and control groups.These results were discussed in relation to various factors, including physical training, which may alter the concentrations of cellular components in the peripheral blood, either through altering the plasma volume and/or by altering the total red cell population.
Comparing risk prediction models
Authors: G. S. Collins, K. G. M. Moons
Journal: BMJ (2012)

Should be routine when deriving a new model for the same purpose 

Risk prediction models have great potential to support clinical decision making and are increasingly incorporated into clinical guidelines.1 Many prediction models have been developed for cardiovascular disease—the Framingham risk score, SCORE, QRISK, and the Reynolds risk score—to mention just a few. With so many prediction models for similar outcomes or target populations, clinicians have to decide which model should be used on their patients. To make this decision they need to know, as a minimum, how well the score predicts disease in people outside the populations used to develop the model (“what is the external validation?”) and which model performs best.2

In a linked research study (doi:10.1136/bmj.e3318), Siontis and colleagues examined the comparative performance of several prespecified cardiovascular risk prediction models for the general population.3 They identified 20 published studies that compared two or more models and they highlighted problems in design, analysis, and reporting. What can be inferred from the findings of this well conducted systematic review?

Firstly, direct comparisons are few. A plea for more direct comparisons is increasingly heard in the field of therapeutic intervention and diagnostic research …
Urinary Calculi in Laos
Authors: Joseph J. Westermeyer
Journal: JAMA (1971)

ABSTRACT To the Editor.— Another country with endemic urinary stone disease can be added to the extensive list compiled by Prien (216:503, 1971). During two years in Laos (1965 to 1967), I had occasion to care for numerous cases of bladder stone. Boys outnumbered girls by three or four to one; in addition they presented much younger than the girls. Indeed, one male infant several months old had symptoms (frequency, tenesmus, hematuria) from the week of his birth. On the other hand, most preteenagers with stone were girls.The stones, moderately large in most cases, had caused symptoms for several months to a few years. Patients suffered cachexia by the time they arrived at the hospital, after various indigenous therapies already had been exhausted. Recovery after removal of the stone proceeded rapidly, however.Bladder stone occurs among a variety of ethnic groups in Laos, but especially among mountaineers (Meo, Khamu,
Avoidable complication of McKee-Farrar arthroplasty.
Authors: C D Jefferiss
Journal: BMJ (1971)

Three cases of abdominal burns occurring consecutively in a large series of patients undergoing total hip replacement with the McKee-Farrar prosthesis and the use of Simplex methyl- methacrylate cement are reported.Case Reports Case 1.-A man aged 78 was noted to have red patches on the abdomen on the first postoperative day consistent with diathermy burns.These became blistered and were a mixture of full and partial-thickness burns.Careful examination of all electrical apparatus, including the lead to the diathermy needle and to the battery-opera- ted device used to stimulate the calves during operation, failed to show any faults.Case 2.-A woman aged 74 had a history similar to that in Case 1, and her burn was full thickness (Fig. 1).Case 3.-A man aged 71 who was operated on one week after the other two cases had only partial-thickness burns.*. : ......+ +.
Pachymeningitis: Rheumatoid or Syphilitic?
Authors: TERRENCE L. RILEY
Journal: Annals of Internal Medicine (1979)

Letters1 October 1979Pachymeningitis: Rheumatoid or Syphilitic?TERRENCE L. RILEYTERRENCE L. RILEYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-4-656_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Although the case of pachymeningitis discussed by Markenson and co-authors in the May issue (1) was presented lucidly with erudite immunologic discussion, one possible case is not considered by the authors: There is no mention in the report of serologic tests for syphilis. The hypertrophic pachymeningitis associated with syphilis has been described by Charcot and Joffroy (2), Gowers (3), and more recently Blackwood and Corsellis (4). Although the lesion when associated with syphilis most often involves the cervical and higher thoracic cord, lumbar involvement can also occur. The clinical presentation, of course, would be ascertained by the...References1. MARKENSONMCDOUGALTSAIRISLOCKSHINCHRISTIAN JJPMC. Rheumatoid meningitis: a localized immune process. Ann Intern Med. 1979;90:786-9. LinkGoogle Scholar2. CHARCOTJOFFROY JA. [TWO cases of progressive muscular atrophy with lesions of the gray matter and anterolateral tracts.] (Fr.) Arch Physiol. 1869;2:354-67, 629-49, 744-60. Google Scholar3. GOWERS W. A Manual of Diseases of the Nervous System, vol. 1. 3rd ed. London: Churchill; 1899. Google Scholar4. BLACKWOODCORSELLIS WJ. Greenfield's Neuropathology. 3rd ed. Chicago: Year Book Medical Publishers; 1976:254-8. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: MC USN National Naval Medical Center Bethesda, MD 20014 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEncephalitis and myelitis in tropical countries: Report from the Task Force on Tropical Diseases by the World Federation of Societies of Intensive and Critical Care Medicine 1 October 1979Volume 91, Issue 4Page: 656-657KeywordsLesionsMeningitisSpinal cordSyphilis Issue Published: 1 October 1979 PDF DownloadLoading ...
Haematomas of the Abdominal Wall
Authors: A. L. d'Abreu, W. Gissane
Journal: BMJ (1967)

Council about the implica- tions for the British medical profession of United Kingdom entry into the European Economic Community (Supplement, 13 May, p. 85) Dr. Derek Stevenson said that " the General Medical Council was fully alive to the dangers that faced doctors if Britain entered the Common Market," and later Dr.A
USPHS Tuberculosis Short-Course Chemotherapy Trial 21: Effectiveness, Toxicity, and Acceptability
Authors: Debra L. Combs
Journal: Annals of Internal Medicine (1990)

Study Objective: To determine the effectiveness, toxicity, and acceptability of a 6-month antituberculous regimen compared with a 9-month regimen. Design: A nonblinded, unbalanced, randomized, multicenter clinical trial. Setting: Twenty-two tuberculosis clinics in public health departments and hospitals in the United States. Patients: Patients were eligible if Mycobacterium tuberculosis, isolated from sputum cultures, was susceptible to study drugs. Of 1451 patients enrolled, 75% (617 of 823) assigned to the 6-month regimen and 71% (445 of 628) assigned to the 9-month regimen were eligible. Interventions: Patients took self-administered isoniazid and rifampin daily for 24 weeks (6-month regimen) or 36 weeks (9-month regimen). In addition, patients assigned to the 6-month regimen took self-administered pyrazinamide daily during the first 8 weeks. Results: Patients on the 6-month regimen converted more rapidly than patients on the 9-month regimen (94.6% compared with 89.9% after 16 weeks of therapy, with a difference of 4.7% [95% CI, 0.7% to 8.7%]); had similar rates of adverse drug reactions (7.7% compared with 6.4%, with a difference of 1.3% [95% CI, 0.0% to 4.6%]); had lower noncompliance rates (16.8% compared with 29.2%, with a difference of 12.4% [95% CI, 6.8% to 18.0%]); and had similar relapse rates 96 weeks after completing therapy (3.5% compared with 2.8%, with a difference of 0.7% [95% CI, 0.0% to 3.9%]). A significantly greater proportion of patients assigned to the 6-month regimen successfully completed therapy (61.4% compared with 50.6%; χ2 = 11.976). Conclusions: Our results suggest that this 6-month regimen is similar in effectiveness, toxicity, and acceptability to the 9-month regimen for treating pulmonary tuberculosis.
Lichen verrucosus et reticularis of Kaposi (porokeratosis striata of Nekam): a manifestation of acquired adult toxoplasmosis
Authors: M.A. MENTER, J.G.L. MORRISON
Journal: British Journal of Dermatology (1976)

Journal Article Lichen verrucosus et reticularis of Kaposi (porokeratosis striata of Nékam): a manifestation of acquired adult toxoplasmosis Get access M.A. MENTER, M.A. MENTER Department of Dermatology, University of Pretoria, South Africa Search for other works by this author on: Oxford Academic Google Scholar J.G.L. MORRISON J.G.L. MORRISON Department of Dermatology, University of Pretoria, South Africa Dr J.G.L. Morrisorij Department of Dermatologyj University of Pretoria, P.O. Box 667, Pretoria, 0001, South Africa. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 94, Issue 6, 1 June 1976, Pages 645–654, https://doi.org/10.1111/j.1365-2133.1976.tb05164.x Published: 01 June 1976
The tale of an anorexic male medical student
Authors: David Gwynfor Samuel
Journal: BMJ (2008)

“I need to go on a diet.” “Does my bum look big in this?” These are not the typical statements you hear in the men’s changing room of the local gym. But to the one in 10 people with anorexia who are male these statements are too close for comfort, as I found out personally during my four year battle with anorexia nervosa.

I had always been a fat child, and I was also born with a congenital deformity of my lower right leg. As these together made me stand out like a sore thumb, I decided as a teenager that the least I could do was to lose some weight. My looking slim and trim would not only benefit my leg but also attract attention from girls, something most teenage boys crave. Unfortunately the health regimen slowly turned into …
Nobel Prize Winners of Switzerland in Physiology and Medicine
Authors: Marvin Kenneth Lane
Journal: New England Journal of Medicine (1953)

During a three-year sojourn in Switzerland, long famous for its watches, cheese and scenic beauty, I have been more than impressed by this little country's amazing facilities for the teaching of medicine and by the quality of medical care given.In this respect it may be worth while briefly to review Switzerland's Nobel Prize Laureates in Physiology and Medicine. Since it is generally acknowledged that the Nobel Prize is the highest award that can be conferred on a scientist, the list of Swiss laureates should give a fairly accurate idea of the country's contribution to medical research. The following list . . .
Functional correction of renal defects in a mouse model for ARPKD through expression of the cloned wild-type Tg737 cDNA
Authors: Bradley K. Yoder, William G. Richards, Carla Sommardahl, William E. Sweeney, Edward J. Michaud, J. Erby Wilkinson, Ellis D. Avner, Richard P. Woychik
Journal: Kidney International (1996)
Epidemiology of hypertension as a public health problem: an overview as background for evaluation of blood lead-blood pressure relationship.
Authors: H A Tyroler
Journal: Environmental Health Perspectives (1988)

An overview of the epidemiology of blood pressure is presented as background for the International Symposium of Blood Lead-Blood Pressure Relationships. The correlates of blood pressure distributions in populations are varied and numerous. They have to be considered as either potential confounders or modifiers of any blood pressure-blood lead relationship detected. The relation of blood pressure to cardiovascular morbidity and mortality emphasizes the importance of detecting and elucidating any possible causal association of blood lead with blood pressure at low levels. The task of this symposium is of public health importance, as relatively minor changes in the distribution and mean levels of blood pressure in populations are associated with major morbidity and mortality consequences.
Through-the-Scope Double Colonic Stenting in the Management of Inoperable Proximal Malignant Colonic Obstruction: a Pilot Study
Authors: C. Shim, J. Cho, I. Jung, C. Ryu, S. Hong, J.-O. Kim, J. Lee, M. Lee, B. Kim
Journal: Endoscopy (2004)

Background and Study Aims: Particularly in cases of proximal colonic obstruction, the long distance and tortuosity of the bowel make it difficult for gastroenterologists and radiologists to advance the stent to the point of the obstruction. The purpose of this study was to evaluate the clinical usefulness and efficacy in preventing stent migration and tumor ingrowth of a new self-expanding through-the-scope (TTS) double colonic stent in the palliative management of patients with inoperable proximal malignant colonic obstruction. Patients and Methods: A total of seven patients (four men, three women; mean age 62 years, range 57 - 68) underwent placement of a newly developed through-the-scope self-expanding double colonic stent. The etiologies of the obstructions at the time of stent insertion were colonic adenocarcinoma (no previous surgical resection) in five cases and metastatic adenocarcinoma from gastric carcinoma in two. The locations of the obstructions were the ascending colon in three cases, the hepatic flexure in two, and the transverse colon in two. To prevent tumor ingrowth and stent migration, an uncovered Niti-S stent (Taewoong Medical Co., Ltd., Seoul, South Korea) was inserted into the stenotic area; a partly membrane-covered Niti-S stent was then again inserted into the stenotic area inside the uncovered Niti-S stent. Results: The self-expanding TTS double colonic stents were placed in the colon in seven patients with acute malignant colonic obstruction. Double stenting was successful in traversing the lesion in six of the seven cases. In one patient, the stent was not successfully placed across the lesion due to a very acute angle at the hepatic flexure. There were no significant complications relating to the insertion, with no clinical or radiographic evidence of perforation or bleeding during or after the procedures, and there were no cases of stent migration or tumor ingrowth during the mean follow-up period of 13 months. Conclusions: Placement of these new self-expanding through-the-scope double colonic stents for the management of inoperable proximal malignant colonic obstruction is a feasible, effective, and safe form of palliative treatment for the prevention of stent migration and tumor ingrowth.
Antimalarial Drugs—Here and On the Horizon
Authors: Tracy Hampton
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preemptive enteral nutrition enriched with eicosapentaenoic acid, gamma-linolenic acid and antioxidants in severe multiple trauma: a prospective, randomized, double-blind study
Authors: Ilya Kagan, Jonathan Cohen, Michael Stein, Itai Bendavid, Dana Pinsker, Veronica Silva, Miriam Theilla, Ronit Anbar, Shaul Lev, Milana Grinev, Pierre Singer
Journal: Intensive Care Medicine (2015)
Seasonal changes in body composition in Australian Rules footballers.
Authors: L M Burke, R A Gollan, R S Read
Journal: British Journal of Sports Medicine (1986)

Anthropometric measurements were collected from a group of Australian Rules footballers at the start and end of the competitive season. Eighty-nine players were studied, drawn from a top level professional league team, a second level association team and an A-grade amateur association team. Changes in the physical profile of these players during the season were observed. A small but significant gain in fat-free body mass in the top level players was observed (0.9 kg, p less than 0.01), but no change in body fat. The intermediate level players showed no significant change in body mass and a tendency toward a slight loss in body fat, while the lower level players showed a significant loss in body fat during the season (1.8 kg, p less than 0.001) without significant change in fat-free body mass.
ARTIFICIAL SELECTION.Read before the Milwaukee Medical Society, Oct. 9, 1894.
Authors: W. H. WASHBURN
Journal: JAMA (1894)

It is by natural selection that those most fitted to succeed in the struggle for existence survive and propagate their kind. The familiar example may be cited of the deer which, being the equal of all the other members of the herd in other respects, is less swift of foot, and hence lagging behind his fellows falls a victim to his feline enemy the panther. His untimely death has eliminated him from the problem and made it impossible for him to become the progenitor of a slow-footed race of deer. The dominant races of men have been evolved by reason of the operation of the law of natural selection. While we may not at this time care to repeat or emulate the violent acts of our forefathers, by which they over-ran the territories of their less ferocious neighbors, appropriating the land, and in many instances slaughtering entire populations, we must
PATTERNS OF PRESSOR RESPONSE TO NOXIOUS STIMULI IN NORMAL, HYPERTENSIVE, AND DIABETIC SUBJECTS*
Authors: Alvin P. Shapiro, Spero E. Moutsos, Emanuel Krifcher
Journal: Journal of Clinical Investigation (1963)

In earlier studies, the influence of various host  affecting the pressor responses to noxious stimuli in hypertensive and normotensive subjects was investigated. Information was obtained indicating that intrinsic factors predominate in determining the type and severity of such pressor responses (1). It also was demonstrated that lowering basal blood pressure in the hypertensive patient with therapeutic doses of reserpine and chlorothiazide did not decrease these responses (2). The present studies represent a continuing effort to define the factors determining patterns of pressor response to noxious stimuli, with particular attention to the physiologic mechanisms that mediate these responses. As in previous studies, the cold pressor test was assumed to measure the neurogenic component, and this response was
IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia
Authors: Lucy S. Hodge, Steve C. Ziesmer, Zhi Zhang Yang, Frank J. Secreto, Morie A. Gertz, Anne J. Novak, Stephen M. Ansell
Journal: Blood (2012)
Doctors' critic resigns from guidance group after protests
Authors: C. Dyer
Journal: BMJ (2010)

The controversial parents’ advocate and campaigner Penny Mellor has stepped down from the General Medical Council’s expert group on child protection in the face of a High Court challenge to the GMC’s decision to recruit her to the group.

Papers served on the GMC by the paediatrician David Southall argue that her inclusion in the group is “illegal, perverse, and unethical” and contrary to the public interest and the spirit of the Safeguarding Vulnerable Groups Act 2006.

Dr Southall also contends that Mrs Mellor’s appointment is contrary to the GMC’s obligations in respecting the professional status and work of the doctors it registers and contrary to its role, as established with the Charity Commission, to regulate professional practice and …
SYMMETRICAL GANGRENE COMPLICATING RHEUMATOID ARTHRITIS
Authors: R. Brooke
Journal: BMJ (1930)

E Bms 493 5 years.This fact, togetlher -withl thle embr-ological aind phb-jiogeiietic positioii of the appendix, lends force to tlle thleory that it ar ises in displaced or embryonic r-emilains; -ot wholeaii we ask wlhv the disl)lace(l cells should take on maligti-nant characteristics at this cals-I age, w-e are met bv thle host of problems relatedl to carcitomona in general.Again, the appendix anid iniflammllationi are closelv related, all(l the miiost frequent age at w-hiich careinoma of the ajl)pendlix appears corresponds to that at which inflamma- tioni of the ap)penidix aplp)ears.The oldest patielnt was aged 81 years, relpoted by Rogg in 1913.Morc cases have