tbuckley/cabot-search huggingface dataset:
The joy of cochlear implants
Authors: M. A. Ibrahim
Journal: BMJ (2014)

“What’s for dinner?” I asked my wife—who, by the way, frequently mumbles when she addresses me—as I entered the house and saw her working in the kitchen. I suspected she had a hearing problem, and so I moved closer and repeated, “What’s for dinner?” Having again received no response, I was almost certain it was because of her hearing loss. I then stood inches behind her and barked, “What’s for dinner?” She turned around to face me and barked right back, “For the third time: chicken!”

When I was about 55 years old, while watching the evening news one night, I realized that I was not able to comprehend some of it, which I attributed to the newsreader not speaking clearly. I also noticed my inability to hear and understand conversations in other situations, and the problem was brought into focus when I started not being able to hear (or understand) questions raised by students after I had given a talk in a large room. I began to have difficulty following conversations in small groups—initially in noisy places, but later in quiet environments as well.

When I could not follow a conversation, my mind would start to wander, and that essentially created an “attention deficit disorder” that exacerbated the hearing loss. In a small group setting, I was thought to be aloof. When lecturing in an auditorium, I would move closer to the person asking the question in order to hear better, and so I was characterized as being a “warm” person (little did they know that “warm” was a cover-up for “deaf”). The fear of not hearing and, therefore, not being able to respond intelligently led me to avoid social gatherings and to decline many speaking engagements. I was worried about becoming socially isolated and about the serious consequences …
DPV-001 an autophagosome-enriched cancer vaccine in phase II clinical trials contains 25 putative cancer antigens, DAMPS, HSPS and agonists for TLR 2, 3, 4, 7 and 9
Authors: Traci L Hilton, Tyler W Hulett, Chistopher Dubay, Rieneke van de Ven, Sandra Aung, Walter J Urba, Hong Ming Hu, Bernard A Fox
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Generation of a therapeutic immune response against a diverse set of antigens expressed by a patient's cancer is a central goal of cancer immunotherapy. This goal is important because diverse responses may prevent escape of antigen loss variants. To accomplish this goal we have
Royal Medical Benevolent Fund Christmas Gifts
Authors: None Webb-Johnson
Journal: BMJ (1954)

Background/Aim: The aim of the study was to evaluate gemcitabine plus nanoparticle albumin-bound paclitaxel (GnP) and FOLFIRINOX for recurrent pancreatic cancer (rPC) after resection. Patients and Methods: Forty-four patients with rPC and 211 with de novo metastatic pancreatic cancer (mPC) who received GnP or FOLFIRINOX as first-line chemotherapy were retrospectively analyzed. Results: On crude analysis, the median overall survival (OS) was significantly longer in the rPC group than in the mPC group (14.0 vs. 10.6 months, respectively; p=0.02). However, the difference was not significant on adjusted analysis using the Cox proportional hazards model (adjusted p=0.90). Patients receiving FOLFIRINOX (n=10) and GnP (n=34) in the rPC group had comparable OS (medians, 12.2 vs. 14.4 months, respectively; p=0.82) even after adjusting for covariates using the Cox model (adjusted p=0.18). Conclusion: The outcomes of patients in the rPC and mPC groups were comparable following chemotherapy. Both FOLFIRINOX and GnP may be reasonable options for treating rPC.
Caring for Strangers
Authors: Michael A. LaCombe
Journal: Annals of Internal Medicine (1997)

On Being a Doctor15 August 1997Caring for StrangersMichael A. LaCombe, MDMichael A. LaCombe, MDBridgton, ME 04009Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-4-199708150-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The quiet young girl with thick eyebrows arching over blue eyes sat quietly, waiting for her chin to be sewn, and took it all in. The room was nearly full. Most of the people waiting with her were familiar to her, seemed to know her, glanced from her to her mother and formed the unspoken gossip with their eyes. This was life in a small town. She avoided their stares much as she suppressed the pain of her chin. Looking through the door, she saw the starched white nurses waiting on the doctor. She didn't ever want to wait on ... Author, Article, and Disclosure InformationAffiliations: Bridgton, ME 04009 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 1997Volume 127, Issue 4Page: 329-330KeywordsEmergency departmentNursesPatient advocacyPatientsResidencyStomachSurgeonsSwimmingSyncopeTouch Issue Published: 15 August 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Complementary Role of Reticuloendothelial and Hepatobiliary Imaging Agents in the Assessment of Liver Disease
Authors: E EDMUND KIM, PEGGY A. DOMSTAD, YOUNG C. CHOY, JOHN J. COUPAL, FRANK H. DeLAND
Journal: Clinical Nuclear Medicine (1982)

The merit of concomitant hepatic imaging with Tc-99m-sulfur colloid (SC) and Tc-99m-HIDA was examined in 40 patients with abnormal liver function tests. The studies were performed sequentially within a 2 to 5 day interval with 5 mCi each of SC or HIDA. Routine static images in all cases, and dynamic studies with HIDA in 15 patients, were graded and compared with the liver function tests and clinical diagnoses. Of the 40 patients, the images with SC showed an abnormality in 22 while HIDA images were abnormal in 38. Thirteen of 21 patients with hepatocellular diseases showed an abnormality of the SC images, and 20 of the same 21 patients had abnormal HIDA images. Abnormal HIDA images were more closely related to abnormal liver function tests. These results suggest that alterations of hepatic function reflected by abnormal liver function tests are better demonstrated with hepatobiliary imaging agents than with reticuloendothelial imaging agents, while either type of imaging agents will detect focal anatomic lesions.
Cognitive coordination and its neurobiological bases: A new continent to explore
Authors: Steven M. Silverstein, William A. Phillips
Journal: Behavioral and Brain Sciences (2003)

Abstract The additional arguments and evidence supplied by the commentaries strengthen the hypothesis that underactivity of NMDA receptors produces impaired cognitive coordination in schizophrenia. This encourages the hope that though the distance from molecules to mind is great, it can nevertheless be traversed. We therefore predict that in this decade or the next molecular psychology will be seen to be as fundamental to our understanding of mind as molecular biology is to our understanding of life.
Type A Viral Hepatitis
Authors: Stanley M. Lemon
Journal: New England Journal of Medicine (1985)

IN recent years, our understanding of the nature and diversity of viruses causing hepatitis in human beings has been sharply increased.1 Those agents now include the viruses of hepatitis A (classic short-incubation infectious hepatitis) and hepatitis B (long-incubation serum hepatitis), one or more still-undefined viruses responsible for "non-A,non-B hepatitis," and the recently recognized delta virus. Among these types of hepatitis, each of which occurs commonly within the United States, hepatitis A is uniquely and primarily transmitted by the fecal—oral route and thus possesses an unequaled potential for epidemic spread. Although it is relatively benign and never eventuates in chronic hepatitis, . . .
Diagnosis of Prostate Cancer Using Differentially Expressed Genes in Stroma
Authors: Zhenyu Jia, Yipeng Wang, Anne Sawyers, Huazhen Yao, Farahnaz Rahmatpanah, Xiao-Qin Xia, Qiang Xu, Rebecca Pio, Tolga Turan, James A. Koziol, Steve Goodison, Philip Carpenter, Jessica Wang-Rodriguez, Anne Simoneau, Frank Meyskens, Manuel Sutton, Waldemar Lernhardt, Thomas Beach, Joseph Monforte, Michael McClelland, Dan Mercola
Journal: Cancer Research (2011)

Abstract More than one million prostate biopsies are performed in the United States every year. A failure to find cancer is not definitive in a significant percentage of patients due to the presence of equivocal structures or continuing clinical suspicion. We have identified gene expression changes in stroma that can detect tumor nearby. We compared gene expression profiles of 13 biopsies containing stroma near tumor and 15 biopsies from volunteers without prostate cancer. About 3,800 significant expression changes were found and thereafter filtered using independent expression profiles to eliminate possible age-related genes and genes expressed at detectable levels in tumor cells. A stroma-specific classifier for nearby tumor was constructed on the basis of 114 candidate genes and tested on 364 independent samples including 243 tumor-bearing samples and 121 nontumor samples (normal biopsies, normal autopsies, remote stroma, as well as stroma within a few millimeters of tumor). The classifier predicted the tumor status of patients using tumor-free samples with an average accuracy of 97% (sensitivity = 98% and specificity = 88%) whereas classifiers trained with sets of 100 randomly generated genes had no diagnostic value. These results indicate that the prostate cancer microenvironment exhibits reproducible changes useful for categorizing the presence of tumor in patients when a prostate sample is derived from near the tumor but does not contain any recognizable tumor. Cancer Res; 71(7); 2476–87. ©2011 AACR.
Incidental Detection of Solitary Hepatic Metastasis by 99mTc-MDP and 18F-NaF PET/CT in a Patient With Osteosarcoma of the Tibia
Authors: Liang Cai, Yue Chen, Zhanwen Huang, Jingbo Wu
Journal: Clinical Nuclear Medicine (2015)

A 36-year-old woman with a history of left above-knee amputation caused by tibial osteosarcoma 3 years ago underwent static 99mTc-MDP bone scintigraphy to evaluate osseous metastases. Although no lesion in the bone was identified, the images showed an intense activity in the region of the liver. This activity was also shown subsequently by 18F-NaF and 18F-FDG PET/CT imaging as a partially calcified lesion in the anterior segment of the right lobe of the liver. Solitary hepatic metastasis form osteosarcoma was suspected and further implied by follow-up studies.
Sex-related Differences in Gastrin Release and Parietal Cell Sensitivity to Gastrin in Healthy Human Beings
Authors: M. Feldman, C. T. Richardson, J. H. Walsh
Journal: Journal of Clinical Investigation (1983)

We compared serum gastrin concentrations and gastric acid secretion basally and in response to a mixed meal in age-matched women and men. Women had significantly higher basal serum gastrin concentrations (P < 0.01) and two- to threefold higher food-stimulated serum gastrin concentrations (P < 0.001) than men. Basal and food-stimulated serum gastrin concentrations in women did not fluctuate significantly during the menstrual cycle. Sex-related differences in food-stimulated serum gastrin concentrations were not due to differences in antral pH because pH after the meal in women and men had been kept constant at 5.0 by in vivo intragastric titration with sodium bicarbonate.
Monitoring of serologic immune parameters in inflammatory skin diseases
Authors: M. Gebhardt, H. C. Wenzel, U. C. Hipler, D. Herrmann, U. Wollina
Journal: Allergy (1997)

This paper deals with the correlation of clinical scoring and serologic markers of inflammation in atopic dermatitis and psoriasis. Serum eosinophil cationic protein (ECP), soluble interleukin-2 receptor (sIL-2R), total serum IgE, IgG and IgM anti-IgE antibodies, and IgE immune complexes were evaluated in monitoring inflammatory skin diseases such as atopic dermatitis and psoriasis. Well-established clinical activity scores were used as standards in recording skin improvement under treatment in a clinical setting. Serum ECP was found to be increased in both atopic dermatitis and psoriasis patients compared to normal controls; sIL-2R and IgE immune complexes were increased only in atopics with increased serum IgE. Anti-IgE antibodies did not show any deviation in both groups of patients. There was a significant elevation of sIL-2R and IgE immune complexes and a nonsignificant elevation of ECP in high-IgE atopics in comparison to those with normal serum IgE. In both groups of patients, there was a significant reduction of ECP and sIL-2R accompanying the improving skin condition. Serum IgE and the other immune parameters failed to respond. In contrast to other studies, serum ECP failed to correspond significantly with disease activity in our study. Our results showed measurable changes of ECP and sIL-2R for atopic dermatitis and/or psoriasis under treatment, but comparison to clinical scores remains difficult due to the different basis of the two systems. The only significant correlation was established for relative changes in sIL-2R and psoriasis area and intensity (PASI), a correlation which might be a useful approach in psoriasis.
Evaluation of the biological effects of police radar RAMER 7F.
Authors: D Rotkovská, J Moc, J Kautská, A Bartonícková, J Keprtová, M Hofer
Journal: Environmental Health Perspectives (1993)

This paper presents results of experiments on the effects of electromagnetic radiation in the millimeter range (frequency 34.0 +/- 0.1 GHz, power density 20 muW/cm2) emitted by a police radar device. Considering the physical properties of the radiation in millimeter range (skin effects), the experiments were carried out on hairless mice. The main physiological parameters tested were body mass, body temperature, peripheral blood, and mass and cellularity of several important organs. Critical organs, the skin, and cornea were examined by electron microscopy. Differentiation ability of hematopoietic cells, progenitors of granulocytes and macrophages, and DNA synthesis in the cornea were compared in irradiated and nonirradiated animals. None of the parameters tested was affected to an extent that would indicate the start of a pathological process or the risk of damage to genetic material.
Antineutrophil antibody: a test for autoimmune primary sclerosing cholangitis in childhood?
Authors: S K Lo, R W Chapman, P Cheeseman, C P Charlton, J A Walker-Smith, G Mieli-Vergani, K A Fleming
Journal: Gut (1993)

The detection of an antineutrophil antibody which is highly sensitive and specific for adult primary sclerosing cholangitis using indirect immunoalkaline phosphatase has been previously described. In this study, the diagnostic potential of this method in childhood primary sclerosing cholangitis is described. A range of 72 blinded children9s sera (36 boys), aged six months to 21 years (10 primary sclerosing cholangitis, eight autoimmune chronic active hepatitis, 10 alpha-1 antitrypsin deficiency, 12 extrahepatic bile duct atresia, 11 ulcerative colitis and 21 normal subjects) was assayed. Eight of the 10 primary sclerosing cholangitis patients were correctly identified. Three patients with chronic active hepatitis also showed the characteristic primary sclerosing cholangitis pattern of staining. No ulcerative colitis patients or any other patients showed this pattern of staining. All normal subjects were negative. As in adult primary sclerosing cholangitis, there is a specific antineutrophil antibody in childhood primary sclerosing cholangitis and this provides further evidence towards an autoimmune aetiology of this condition. The test may have diagnostic potential.
Dietary Protein and Weight Gain—Reply
Authors: Leanne M. Redman
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
176 BACTERIAL INFECTIONS AND SEPSIS ACUTELY DETERIORATE LIVER FUNCTION IN CIRRHOTIC PATIENTS: A PROSPECTIVE STUDY
Authors: C. Lucidi, V. Giannelli, M. Giusto, A. Ruffa, P.A. Galtieri, M. Venditti, A.F. Attili, O. Riggio, M. Merli
Journal: Journal of Hepatology (2010)
Agency launches advice to reduce number of prescribing errors
Authors: Helen Mooney
Journal: BMJ (2007)

The National Patient Safety Agency (NPSA) has called for the number of preventable errors in the dispensing of drugs to be reduced.

Launching two new additions to its “Design for Patient Safety” series, the agency aims to offer guidance for drug dispensers in England.

The booklets are intended to help professionals ensure that labelling and design are clear and accurate and that dispensing environments are safe and help to reduce the likelihood of errors.

The agency’s chief executive, Martin Fletcher, said, “The proportion of errors …
Lack of clinical utility of bronchoalveolar lavage cultures for cytomegalovirus in HIV infection.
Authors: M Mann, J H Shelhamer, H Masur, V J Gill, W Travis, D Solomon, J Manischewitz, F Stock, H C Lane, F P Ognibene
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

This study assessed the presence of cytomegalovirus (CMV) in bronchoalveolar lavage (BAL) in three subpopulations of HIV-infected patients and correlated its presence with clinical status during 3 mo of follow-up. Nineteen asymptomatic volunteers, six patients with CMV retinitis, and 46 patients with acute pulmonary symptoms underwent BAL and were assessed for CMV by cytopathology, conventional shell vial cultures, and antigen detection. Transbronchial biopsies were also obtained when possible and evaluated for histopathologic changes of CMV. All patients were followed for approximately 3 mo. Cytomegalovirus was detected in BAL in nine of 19 (47%) asymptomatic volunteers, in all six patients with CMV retinitis, and in 33 of 46 (72%) patients with pulmonary symptoms. Only one symptomatic patient with a positive CMV BAL culture developed clinically significant CMV pulmonary disease; this patient developed disseminated CMV and died. The only other death occurred in a patient with CMV retinitis who developed staphylococcal bacteremia. None of the asymptomatic volunteers or patients with CMV retinitis developed evidence of CMV pneumonia or any other organ disease with CMV. Cytomegalovirus is frequently detected in BAL from HIV-infected patients regardless of their pulmonary symptoms and its presence does not clinically predict significant pulmonary morbidity or mortality in 3 mo of follow-up.
ICCE Consensus for Celiac Disease
Authors: C. Cellier, P. H. Green, P. Collin, J. Murray
Journal: Endoscopy (2005)

Celiac disease is a disorder in which the ingestion of cereals results in small-intestinal mucosal damage in genetically susceptible individuals. The mucosal lesion develops gradually from inflammation, to crypt hyperplasia and partial or subtotal villous atrophy. The prevalence of celiac disease is now estimated at almost 1 % of the general population in Europe and the United States.
Therapeutic end points for the treatment of atrioventricular node reentrant tachycardia by catheter-guided radiofrequency current
Authors: Bruce D. Lindsay, Mina K. Chung, M. Carolyn Gamache, Robert A. Luke, Kenneth B. Schechtman, Judy L. Osborn, Michael E. Cain
Journal: Journal of the American College of Cardiology (1993)
Studies on osteoporosis.
Authors: A. Elkeles
Journal: BMJ (1968)

MEDIBALRJURNAa sexual contact by gonorrhoea patients is a valid candidate for the procedure known as " epidemiologic treatment " even when cul- tures (which may miss 20%, or more of such gonococcal infections) are negative.If chemotherapy is adequate, a link in a chain of infection may thus be broken.A patient who would refuse a diagnosis of venereal disease may willingly accept this precautionary measure, just as chemoprophylaxis is accepted for ophthalmia neonatorum.-Iam, etc
1019 GENETIC POLYMORPHISM ASSOCIATED WITH POOR LONG-TERM OUTCOME OF HEPATOCELLULAR CARCINOMA PATIENTS FOLLOWING THE COMBINED THERAPY WITH TRANSARTERIAL CHEMOEMBOLIZATION AND SORAFENIB
Authors: J.-H. Lee, Y.-H. Chung, J.A. Kim, E.-S. Shin, D. Lee, J.H. Shim, H.C. Lee, J.H. Yoon, B.I. Kim, S.H. Bae, K.C. Koh, G. Kim, N.-H. Park
Journal: Journal of Hepatology (2012)
Negligence of medical experts
Authors: Elliott Foucar
Journal: BMJ (2005)

Reduction in mortality from breast cancerDecrease with screening was marked in younger age group Editor-Based on a complicated statistical model, Olsen et al reported that the breast cancer mortality in Copenhagen dropped by 25% for women aged 50-79 when comparing mortality in the screening period (1991-2001) with a pre-screening period (1981-91) and claimed that this decrease was caused by screening. 1According to Statistics Denmark, 217 breast cancer deaths occurred in Copenhagen in the age group 35-54 years in the period 1981-90 and 196 deaths in 1991-2000. 2By comparing these data with those in the article by Olsen et al we calculate that less than 5% of the breast cancer mortality in this age group is caused by tumours diagnosed after age 50 years when women were invited to screening.The number of exposure years increased from about 484 000 to about 538 000.This gives a significant 19% (age adjusted) reduction in breast cancer mortality in the age group 35-54 years.No reduction at all occurred in the age group 55-79. 2Our estimates are based on raw and complete data.In contrast, the estimates in the paper by Olsen et al are sensitive to exclusion of data and model choice.In Copenhagen a drop in breast cancer mortality may reflect a higher fertility quotient due to non-Western immigration, fewer nulliparous women, and other non-screening related factors.It is therefore strange that no causal note was made by Olsen et al on the marked decrease in the breast cancer mortality in the age group 35-54 years.