Intravenous Immunoglobulins in Gram-Negative Bacteremia
Authors: P. H. Chandrasekar
Journal: Annals of Internal Medicine (1990)

Letters1 December 1990Intravenous Immunoglobulins in Gram-Negative BacteremiaP. H. Chandrasekar, MDP. H. Chandrasekar, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-11-897 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:I wish to point out a significant omission in the otherwise excellent article by Berkman and colleagues (1) on clinical uses of intravenous immunoglobulins. The possible utility of immunoglobulins as adjunctive agents in the management of gram-negative bacterial infection deserves discussion. The high mortality associated with serious gram-negative bacterial infection has generated much interest in the evaluation of antibody efficacy in the treatment of such infections. In 1982, Ziegler and colleagues (2) established that administration of immune serum obtained from volunteers who had been immunized with rough mutants of J5Escherichia colidecreased the mortality rate by...References1. Berkman S, Lee M, and Gale R. Clinical uses of intravenous immunoglobulins. Ann Intern Med. 1990;112:278-92. LinkGoogle Scholar2. Ziegler E, McCutcheon J, and Fierer J. Treatment of gram-negative bacteremia and shock with human antiserum to mutant Escherichia coli. N Engl J Med. 1982;307:1254-60. CrossrefGoogle Scholar3. Calandra T, Glauser M, and Schellekens J. Treatment of gram-negative septic shock with human IgG antibody to Escherichia coli J5: a prospective, double-blind, randomized trial. J Infect Dis. 1988;158:312-9. CrossrefMedlineGoogle Scholar4. Pizzo P. Potential applications of immunoglobulin therapy in cancer patients. Infections in Medicine [Special Supplement]. October 1989:16-22. Google Scholar5. Just H, Vogel W, and Metzger M. Treatment of intensive care unit patients with severe nosocomial infections. In: Morell A, Nydegger VE, eds. Clinical Use of Intravenous Immunoglobulins. London: Academic Press; 1986:345-52. Google Scholar1. Sullivan K, Kopecky K, and Jocom J. Immunomodulatory and antimicrobial efficacy of intravenous immunoglobulin in bone marrow transplantation. N Engl J Med. 1990;323:705-12. CrossrefMedlineGoogle Scholar2. Winston D, Ho W, and Lin C. Intravenous immune globulin for prevention of cytomegalovirus infection and interstitial pneumonia after bone marrow transplantation. Ann Intern Med. 1987;106:12-8. LinkGoogle Scholar3. Cometta A, Baumgartner J, Lee M, and Glauser M. Prophylaxis of infection in high risk surgical patients (pat) with standard intravenous immunoglobulin G (St-IVIG) or with antibody to core glycolipid (Co-IVIG) [Abstract]. Proceedings of the 30th International Conference on Antimicrobial Agents and Chemotherapy, Atlanta, GA, 14-18 October 1990. Google Scholar4. Ziegler E, Fisher C, Sprung C, Straube R, and Sadoff J. Prevention of death from gram negative bacteremia and sepsis by HA-1A, a human monoclonal antibody specific for lipid A of endotoxin: results of phase III trial [Abstract]. Clin Res. 1990;38:304A. Google Scholar5. Gorelick K, Jacobs R, Chmel H, Trenholme G, and Greenman R. Efficacy results of a randomized multicenter trial of E5 antiendotoxin monoclonal antibody in patients with suspected gram-negative sepsis. Proceedings of the 29th International Conference on Antimicrobial Agents and Chemotherapy, Houston, TX, 17-20 September 1989. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: P. H. Chandrasekar, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1990Volume 113, Issue 11Page: 897-898KeywordsBacteremiaDeath ratesEscherichia coliGram negative bacterial infectionsImmune serumIntravenous immunoglobulinMortality ePublished: 1 December 2008 Issue Published: 1 December 1990 PDF downloadLoading ...