tbuckley/cabot-search huggingface dataset:
Abstract 1977: The protein phosphatase 2 subunit PR48 is a novel melanoma tumor suppressor gene.
Authors: Léon CL van Kempen, Jonathan Jarry, Mounib Elchebly, Margaret Redpath, Per-Henrík Edqvist, Fredrik Pontén, Richard Scolyer, Dirk Schadendorf, Celia M.T. Greenwood, Joost van den Oord, Alan Spatz
Journal: Cancer Research (2013)

Abstract Cutaneous melanoma cell proliferation is a strong prognostic factor for distant metastasis free survival (DMFS). In the current study we tested if aberrant expression of a regulator both DNA replication and cell cycle progression, i.e. the protein phosphatase 2A subunit PR48, could be a driver of melanoma proliferation and progression. Quantitative analysis of PR48 mRNA expression revealed a strong correlation between low levels of expression and poor DMFS in a multivariate analysis (n=49, p=0.0007). In line with this, no or low PR48 protein expression was associated with poor overall survival in three independent samples sets of melanoma (n=339, P&amp;lt;0.001), and reduced PR48 expression correlated with increased proliferation (P=0.0023). Functional analysis using over expression and knock down strategies in melanoma cell lines demonstrated that PR48 alters cdc6-cdt1 complex formation, regulates pRb phosphorylation status, and entry into the S-phase of the cycle progression. Ectopic PR48 expression decreased tumorigenicity of melanoma cells, and shRNA-mediated reduced PR48 expression increased tumor take and growth in nude mice. Our data demonstrate that PPP2R3B is a novel tumor suppressor gene in melanoma, whose loss of expression contributes increased proliferation and poor survival. Citation Format: Léon CL van Kempen, Jonathan Jarry, Mounib Elchebly, Margaret Redpath, Per-Henrík Edqvist, Fredrik Pontén, Richard Scolyer, Dirk Schadendorf, Celia M.T. Greenwood, Joost van den Oord, Alan Spatz. The protein phosphatase 2 subunit PR48 is a novel melanoma tumor suppressor gene. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1977. doi:10.1158/1538-7445.AM2013-1977
Monoclonal antibody IAC-1 is specific for activated α2β1 and binds to amino acids 199 to 201 of the integrin α2 I-domain
Authors: Anne Schoolmeester, Karen Vanhoorelbeke, Shinya Katsutani, Hilde Depraetere, Hendrik B. Feys, Johan M. W. Heemskerk, Marc F. Hoylaerts, Hans Deckmyn
Journal: Blood (2004)
Is serum bilirubin concentration the only valid prognostic marker in primary biliary cirrhosis?
Authors: Piotr Krzeski, Wlodzimierz Zych, Ewa Kraszewska, Bohdan Milewski, Eugeniusz Butruk, Andrzej Habior
Journal: Hepatology (1999)

From the many prognostic models for primary biliary cirrhosis (PBC) patients based on Cox's regression analysis, the Mayo model has gained the most popularity and was successfully validated in some centers. The aim of our study was to validate the Mayo survival model for Polish PBC patients and, in case of its inapplicability, to select prognostic variables and to create time-fixed and time-dependent survival models for the patients. We used database information on patients from 6 medical centers in Poland, fulfilling clinical, serological, and/or pathological criteria of PBC. The Mayo model was validated using data from 116 PBC patients. The time-fixed and time-dependent models were created using data on clinical and biochemical variables used in the Mayo model from 162 and 208 patients, respectively. The Mayo model validation was performed graphically and by one-sample log-rank tests after dividing the study sample into 3 groups of high, medium, and low risk. The survival analysis was performed using Cox's proportional hazards regression method on clinical and biochemical variables used in the Mayo model. Treatment with ursodeoxycholic acid (UDCA) was included in the time-dependent analysis. Validation showed that the Mayo model overestimated death risk in Polish PBC patients. Of the variables used in the Mayo model, serum bilirubin concentration appeared to be the only variable of prognostic importance. The analysis shows that serum bilirubin concentration holds most of the prognostic information for our PBC patients irrespective of prior treatment with UDCA.
Integrating longitudinal information on pulmonary function and inflammation using asthma phenotypes
Authors: Tadao Nagasaki, Hisako Matsumoto, Yoshihiro Kanemitsu, Kenji Izuhara, Yuji Tohda, Hideo Kita, Takahiko Horiguchi, Kazunobu Kuwabara, Keisuke Tomii, Kojiro Otsuka, Masaki Fujimura, Noriyuki Ohkura, Katsuyuki Tomita, Akihito Yokoyama, Hiroshi Ohnishi, Yasutaka Nakano, Tetsuya Oguma, Soichiro Hozawa, Isao Ito, Tsuyoshi Oguma, Hideki Inoue, Tomoko Tajiri, Toshiyuki Iwata, Yumi Izuhara, Junya Ono, Shoichiro Ohta, Tetsuji Yokoyama, Akio Niimi, Michiaki Mishima
Journal: Journal of Allergy and Clinical Immunology (2014)
REPORT OF THE COMMITTEE ON ESTIMATING COMPENSATION FOR EYE INJURIES
Authors: Nelson M. Black
Journal: JAMA (1923)

To the Chairman and Members of the Section on Ophthalmology of the American Medical Association: Your committee, after careful consideration of numerous legal opinions relative to compensation for eye injuries, and after consultation with various industrial engineers and members of industrial commissions, has arrived at the conclusion that there is much research work needed to establish certain values mentioned in the reports heretofore presented. This research work has been inaugurated, and the committee wishes to report progress and requests its continuance in order to complete the work before submitting a final report. The following is an outline of the work undertaken: 1. The question as to what percentage of average normal visual acuity and field of vision constitutes industrial blindness must first be settled. Then the industrial visual efficiency rating of the injured eye may be determined as the product of the industrial visual acuity rating by the industrial visual
Localized relapse in bone marrow of extremities after allogeneic stem cell transplantation for acute lymphoblastic leukemia
Authors: T. Endo, N. Sato, K. Koizumi, M. Nishio, K. Fujimoto, T. Sakai, K. Kumano, M. Obara, K. Minauchi, T. Koike
Journal: American Journal of Hematology (2004)

Abstract We report a patient with a relapsed in bone marrow of extremities after allogeneic peripheral blood stem cell transplantation for acute lymphoblastic leukemia (ALL). The patient complained of pain in the right upper arm and left leg 15 months after transplantation. Magnetic resonance imaging (MRI) and fluorine‐18 fluorodeoxyglucose positron emission tomography (FDG‐PET) showed abnormal findings in bone marrow of upper and lower extremities. There were no findings of relapse in aspirates from the sternum and iliac bone marrow. Biopsy specimen from the iliac bone marrow showed normocellular marrow without leukemic cells. Biopsy specimen from the right humerus revealed marked leukemic cell infiltration in the bone marrow. This is apparently the first case of localized relapse of ALL in bone marrow of extremities. Physicians should be aware of unusual relapse sites of leukemia after allogeneic stem cell transplantation. MRI and FDG‐PET may be of value in detecting this type of relapse. Am. J. Hematol. 76:279–282, 2004. © 2004 Wiley‐Liss, Inc.
Pathology of the Skin with Clinical Correlations
Authors: David Slater
Journal: British Journal of Dermatology (2005)

Journal Article Pathology of the Skin with Clinical Correlations Get access David Slater David Slater Department of Histopathology, Royal Hallamshire Hospital, Sheffield S10 2JF, U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 154, Issue 2, 1 February 2006, Pages 388–389, https://doi.org/10.1111/j.1365-2133.2005.07060.x Published: 01 February 2006
Diagnosis of Acute Abdominal Disease
Authors: E. R. Woodward
Journal: JAMA (1980)

<i>Diagnosis of Acute Abdominal Disease</i>begins with several introductory chapters that include an excellent summary of visceral anatomy and a thoughtful neurological explanation of the vagaries of abdominal pain. The enormous importance of an accurate history is stressed, and pertinent physical findings are explained pathophysiologically. Appropriate, although secondary, uses of laboratory and radiologic procedures are well illustrated. The chapter on inflammatory disease is probably the high point of the volume. Appendicitis receives its much deserved emphasis. One is a little chagrined at the mention of a leukocytosis of 15,000 to 25,000/cu mm as a diagnostic criterion, considering this heralds rather advanced disease. However, the correlation of physical, history, laboratory, and radiologic findings is done well. A second large chapter is concerned with obstructive diseases. Again, the clinical correlation is excellent. Acute cholecystitis is arbitrarily assigned to this chapter and is well discussed. Shorter chapters deal with perforated viscus, infant abdominal
Spontaneous resolution of lichen myxoedematosus
Authors: R.A. HARDIE, J.A.A. HUNTER, S. URBANIAK, J.A. HABESHAWJ
Journal: British Journal of Dermatology (1979)

Journal Article Spontaneous resolution of lichen myxoedematosus Get access R.A. HARDIE, R.A. HARDIE Department of Dermatology, Royal Infirmary, Edinburgh Search for other works by this author on: Oxford Academic Google Scholar J.A.A. HUNTER, J.A.A. HUNTER Department of Dermatology, Royal Infirmary, Edinburgh Search for other works by this author on: Oxford Academic Google Scholar S. URBANIAK, S. URBANIAK Department of Regional Blood Transfusion Centre, Royal Infirmary, Edinburgh Search for other works by this author on: Oxford Academic Google Scholar J.A. HABESHAWJ J.A. HABESHAWJ Department of Pathology, University of Edinburgh Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 100, Issue 6, 1 June 1979, Pages 727–730, https://doi.org/10.1111/j.1365-2133.1979.tb08080.x Published: 01 June 1979
Prothrombin “Mexico city,” an asymptomatic autosomal dominant prothrombin variant
Authors: Matilde Valls‐de‐Ruiz, Alejandro Rulz‐Arguelles, Guillermo J. Ruiz‐Arguelles, Raul Ambriz
Journal: American Journal of Hematology (1987)

A functionally normal but structurally abnormal prothrombin variant was found in a Mexican family. Immunoisoelectricfocusing studies revealed that this variant has a more acidic isoelectric point (4.01) than normal prothrombin (4.29), but it proved to have a normal molecular weight as assessed by sodium-dodecyl-sulphate polyacrylamide gel electrophoresis. Two-dimensional immunoelectrophoresis studies showed an abnormal cleavage of the prothrombin molecule by factor Xa and Echis carinatus venom as well, despite the fact that both yield functionally normal thrombin molecules. Finally, the ability of the molecule to bind calcium ions as well as its overall antigenic structure were investigated and found to be normal. These results taken together suggest a simple (substitution or translocation) mutation at the fragment 2 level. Since this prothrombin variant is different from others described previously, the name "Mexico City" is proposed to identify it.
Passive smoking, salivary cotinine concentrations, and middle ear effusion in 7 year old children.
Authors: D. P. Strachan, M. J. Jarvis, C. Feyerabend
Journal: BMJ (1989)

OBJECTIVE--To assess the contribution of passive exposure to tobacco smoke to the development of middle ear underpressure and effusion. DESIGN--Cross sectional observational study. SETTING--One third of the primary schools in Edinburgh. SUBJECTS--892 Children aged 6 1/2 to 7 1/2 were examined, and satisfactory tympanograms were obtained in 872. Results of assay of salivary cotinine concentrations were available for 770 children, and satisfactory tympanograms were available for 736 of these. END POINT--Correlation of the prevalence of middle ear underpressure and effusion with concentrations of the marker of nicotine, cotinine, in the saliva of the children. MEASUREMENTS AND MAIN RESULTS--Middle ear pressure and compliance were measured in both ears by impedance tympanometry. Salivary cotinine concentrations were assayed by gas-liquid chromatography. Cotinine concentrations increased with the number of smokers in the household. Girls had higher concentrations than boys, and children living in rented housing had higher concentrations than those living in housing owned by their parents. There was a trend towards more abnormal tympanometric findings with increasing cotinine concentration, the odds ratio for a doubling of the cotinine concentration being 1.14 (95% confidence interval 1.03 to 1.27). After adjustment for the sex of the child and housing tenure the odds ratio for a doubling of the cotinine concentration was 1.13 (1.00 to 1.28). CONCLUSIONS--The results of this study are consistent with those of case-control studies of children attending for an operation to relieve middle ear effusion. They indicate that the disease should be added to the list of recognised hazards associated with passive smoking. About one third of the cases of middle ear effusion in this study were statistically attributable to exposure to tobacco smoke.
Increased Sympathetic Nerve Activity Following Resection of Coarctation of the Thoracic Aorta
Authors: MCC. GOODALL, W. C. SEALY
Journal: Circulation (1969)

Twenty patients who underwent resection of the thoracic aorta and six patients operated on for hiatial hernia, patent ductus, mitral insufficiency, or A-V fistula were studied to determine whether there was an increase in sympatho-adrenal medullary activity following resection. Daily 24-hour urine samples were collected from each patient and control, and outputs of noradrenaline (norepinephrine) and adrenaline (epinephrine) were determined. The preoperative outputs were similar in the coarctation group and the controls. Postoperatively, however, although noradrenaline was elevated in both groups, it was elevated more in the coarctation group and remained elevated for a longer period than in the control subjects. Both the subjects with coarctation and the controls had marked increases in urinary output of adrenaline after operation. In the coarctation arctation group, however, the increase was greater and extended for a longer period. The mechanism for increase in noradrenaline output seems to be directly related to the baroreceptors. After resection of aorta for coarctation, pressure in the proximal segment of the aorta decreases. The proximal baroreceptors then reduce their inhibitory influence on the bulbar vasomotor centers, and these centers, in order to compensate for the decreased proximal blood pressure, increase sympathetic nerve activity which is reflected by an increased release of noradrenaline.
Pneumococcal Septicaemia with Recovery
Authors: J. E. Murray, S. Oram
Journal: BMJ (1941)

Excluding the transient bacteriaemia of lobar pneumonia very few instances have been recorded of pneumococcal septicaemia, proved by blood culture, in which a cure has been obtained as a result of giving sulphapyridine.The case to be described presents sufficient unusual features to make it worth publishing. Case HistoryThe patient, an Army officer aged 39, was wounded on May 20, 1940, in Norway by flying bomb-splinters, and received a severe laceration of his left calf and a small wound below the left patella.No fracture was sustained.He was admitted to a Liverpool hospital, and the infrapatellar wound completely healed within six weeks.The calf wound was treated by r t- 0 1,4.1; 3 -.i F -. I :RI I .i.
31Metabolomic identification of substrates for monoamine oxidases in hearts subjected to oxidative stress
Authors: M Canton, A Castegna, R Menabo', I Spera, E M Palmieri, F Di Lisa
Journal: Cardiovascular Research (2014)

Purpose: Oxidative stress plays a key role in cardiac diseases, although the sources of reactive oxygen species (ROS) have not been defined conclusively. Recent studies demonstrated that the mitochondrial enzymes monoamine oxidases (MAO) are a major source of ROS in reperfusion injury and decompensated hypertrophy. The present study characterized the molecular mechanisms responsible for the increased activity of MAO. Based upon available information, the activity of these enzymes depends mostly on substrate availability. Therefore, we aimed at identifying the major substrates of MAO in hearts undergoing oxidative stress. Mass spectrometry was used to identify and quantitate potential substrates by comparing their contents in the absence and the presence of MAO inhibition. Methods and Results: Firstly, we applied a metabolomic profiling method to investigate changes in amine contents in isolated mouse hearts, by means of a LC-MS/MS approach in the precursor ion scanning mode. Maximal oxidative stress was induced by perfusing isolated mouse hearts with 1 mM hydrogen peroxide for 15 min. Addition of 0.5 mM pargyline to the perfusion buffer 10 min before hydrogen peroxide resulted in a significant increased content of the typical MAO substrates serotonin and epinephrine, along with histamine and its product N1-methyl histamine. N1-methyl histamine was found to be the more aboundant metabolite and its content displayed a 180% increase in pargyline-treated hearts, as compared to the untreated ones. The accumulation of MAO substrates upon pargyline treatment correlated with a reduced MAO-dependent production of hydrogen peroxide. In fact we observed a decreased extent of (i) oxidation of myofibrillar proteins, as detected by disulfide bond formation in tropomyosin (Western blot under non reducing conditions), and (ii) ROS levels in tissue, as detected by dihydroethidine (DHE) staining. Surprisingly, these findings imply that the profound injury induced by H2O2 administration is not due to a direct action. Indeed, H2O2 perfusion appears to trigger an amplification pathway whereby the increase in MAO activity due to a larger substrate availability is the end-effector of the initial oxidative stress. Conclusions: This study provides the first information on endogenous substrates of MAO becoming available under conditions of oxidative stress that is then amplified by the increased MAO activity. The identification of histamine and N1-methyl histamine, that are involved in neurotransmission and immune response, suggests a significant trafficking of MAO substrates between myocytes and non-myocyte cells in the heart.
Bacillemia in Primary Tuberculosis
Authors: DONALD W. SMITH
Journal: Annals of Internal Medicine (1971)

Letters, Comments, and Corrections1 September 1971Bacillemia in Primary TuberculosisDONALD W. SMITH, M.D.DONALD W. SMITH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-3-479_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We were pleased to see Dr. Stead and Dr. Bates' article on "silent" bacillemia in primary tuberculosis in the April ANNALS(74:559-561, 1971). Several papers were referenced that supported their statement that bacillemia in the course of primary tuberculosis has been demonstrated in animals. We wish to call attention to a demonstration of a bacillemia in animals reported in a paper (SMITH, MCMURRAY, WIEGESHAUS, et al:Am Rev Resp Dis102:937-949, 1970) published while the Stead-Bates paper was in press. Our reason for calling attention to this paper is that evidence was obtained of a bacillemia in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1971Volume 75, Issue 3Page: 479-480 Issue Published: 1 September 1971 PDF downloadLoading ...
Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways
Authors: Vincent F-S Shih, Jeremy Davis-Turak, Monica Macal, Jenny Q Huang, Julia Ponomarenko, Jeffrey D Kearns, Tony Yu, Riku Fagerlund, Masataka Asagiri, Elina I Zuniga, Alexander Hoffmann
Journal: Nature Immunology (2012)
Das naturalistische Missverständnis der Psychoanalyse – ihre Folgen und ihre mögliche Überwindung
Authors: Melitta Mitscherlich
Journal: Psychotherapy and Psychosomatics (1974)

Research Articles| February 12 2010 Das naturalistische Missverständnis der Psychoanalyse – ihre Folgen und ihre mögliche Überwindung Subject Area: Psychiatry and Psychology Melitta Mitscherlich Melitta Mitscherlich Düsseldorf Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1974) 24 (4-6): 444–448. https://doi.org/10.1159/000286782 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Melitta Mitscherlich; Das naturalistische Missverständnis der Psychoanalyse – ihre Folgen und ihre mögliche Überwindung. Psychother Psychosom 31 December 1974; 24 (4-6): 444–448. https://doi.org/10.1159/000286782 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1974Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
X-Ray Visualization of the Intervertebral Disk
Authors: Robert E. Wise, W. James Gardner, Robert B. Hosier
Journal: New England Journal of Medicine (1957)

IN 1948 and 1950 Lindblom1 , 2 reported his experience with diskography. In these reports he described a method of direct visualization of normal and pathologic lumbar intervertebral disks by means of the injection of a readily absorbable contrast medium into the substance of the disk. The procedure appeared to have considerable promise. Our first experience was reported in 1951.3 Subsequent experiences with 89 patients upon whom 169 satisfactory diskograms were obtained were published in 1952.4 The present report includes an additional 165 patients upon whom 339 disks were injected. Sixty-eight of these patients were operated upon, with exploration of 107 disks. . . .