tbuckley/cabot-search huggingface dataset:
(14) Photoallergic contact dermatitis due to 2-hydroxy, 4-methoxybenzophenone (oxybenzone): report of four cases
Authors: M.C. Marguery, J. Bazex
Journal: British Journal of Dermatology (1989)

Journal Article (14) Photoallergic contact dermatitis due to 2‐hydroxy, 4‐methoxybenzophenone (oxybenzone): report of four cases Get access M.C. Marguery, M.C. Marguery Hôpitaux de Toulouse, Toulouse Search for other works by this author on: Oxford Academic Google Scholar J. Bazex J. Bazex Hôpitaux de Toulouse, Toulouse Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 121, Issue s34, 1 July 1989, Pages 59–60, https://doi.org/10.1111/j.1365-2133.1989.tb05965.x Published: 01 July 1989
Deep sea sedimentation
Authors: Pierre E. Biscaye
Journal: Environmental Health Perspectives (1974)

An important problem in the study of microparticles in the marine environment, suspended in the water column or deposited as sediment on the ocean bottom, is the determination of provenance of the microparticles-where did they come from and by what processes were they transported to the sampling location? Two techniques of possible interest to those concerned with tracing the origins and dispersion paths of asbestos particles are described. One utilizes variations in the naturally occurring rubidium-strontium isotope system and is used to characterize a bulk sample, i.e., a large number of particles. The other utilizes scanning electron microscopy to observe variations in surface texture of individual grains which, in the case of quartz particles in the natural environment, can be related to the transport processes to which they have been subjected.
692. Bone Marrow Derived Neural Stem-Like Cells Expressing IL-27 Exhibit Antitumor Activity in Intracranial Gliomas
Authors: Xiangpeng Yuan, Jinwei Hu, Takayuki Yoshimoto, Keith L. Black, John S. Yu
Journal: Molecular Therapy (2005)

Fetal brain derived neural stem cells are capable of tracking migratory and invasive brain tumor and delivering therapeutic molecules into the infiltrating tumor foci. In the present study we isolated neural stem-like cells from whole bone marrow of adult C57bl/6 mice. These bone marrow derived neural stem-like cells (BM-NSCs) grew as spheres morphologically indistinguishable from the neurospheres of fetal brain neural stem cells and expressed neural stem cell marker. Upon in vitro differentiation, the BM-NSCs were capable of producing progenies of three lineages, neurons, astrocytes, oligodendrocytes. After in vivo implantation, the cells were capable of tracking intracranial glioma cells by migrating into tumor mass and in immediate proximity to and intermixed with invading tumor |[ldquo]|island|[rdquo]|. We combined this tumor tracking property of BM-NSCs with gene immunotherapy by transducing the cells with a new discovered cytokine IL-27 that plays a role in the initiation of T help cell 1 responses. BM-NSCs transduced by an adenoviral vector carrying the single-chain IL-27 cDNA or by an empty vector as control were injected into the brain of C57bl/6 mice bearing intracranial GL-26 gliomas. About 50% mice survived intracranial gliomas after the implantation of IL-27 transduced BM-NSCs. In contrast, implanting empty vector transduced BM-NSCs did not rescue the intracranial glioma-bearing mice. Enhanced T cells infiltration within the tumors were observed in brain sections of the mice treated by IL-27 expressing BM-NSCs. Cytotoxic T lymphocyte (CTL) assay of the spleen cells from the survived mice shown that CTL activities against GL-26 glioma but not irrelevant tumor were augmented. In addition, the mice survived intracranial glioma after IL-27 expressing BM-NSCs treatment were resistant to intracranial rechallenge with the same GL-26 glioma cell line. Consistent with this observation, increased IFN-|[gamma]| expression was detected in the brain tissue after the rechallenge. Furthermore, depleting particular lymphocytes demonstrated that CD8+ T cells were crucial for the IL-27 expressing BM-NSCs antitumor activity. Taken together, these data suggest that BM-NSCs can be a tumor tracking vehicle for targeting refractory, migratory, invasive brain tumor to deliver therapeutic molecules into tumor foci. IL-27 as a new cytokine has potent ability to induce tumor-specific antitumor activity and protective immunity. By combining the tumor tracking property with the potent antitumor immunity, IL-27 expressing BM-NSCs may represent a promising gene therapy treatment for brain tumors.
Should intake of carbon monoxide be used as a guide to intake of other smoke constituents?
Authors: H Ashton, R Stepney, J W Thompson
Journal: BMJ (1981)

The relation between blood carboxyhaemoglobin (COHb) and plasma nicotine concentrations was studied in a group of 12 smokers smoking cigarettes of three levels of standard delivery. While the intake of carbon monoxide from a single cigarette was unrelated to the intake of nicotine, presmoking "trough" concentrations of the two substances (reflecting longer-term exposure) were highly correlated. Various other measures of nicotine exposure were at best only moderately correlated with blood nicotine concentrations. Thus trough COHb concentrations might be used to provide a reliable indication of the exposure to nicotine of individual smokers smoking the same type of cigarette, and of the relative exposure to nicotine of populations smoking cigarettes of different standard deliveries.
Nodular regenerative hyperplasia of the liver following bone marrow transplantation
Authors: Dale C. Snover, Sally Weisdorf, Joseph Bloomer, Philip McGlave, Daniel Weisdorf
Journal: Hepatology (1989)

Liver disease in the early period following bone marrow transplantation may be due to a number of causes, including pretransplant cytoreduction with chemotherapy and irradiation. Although the relationship of venoocclusive disease to these agents has been well established, another process, nodular regenerative hyperplasia, may also occur. In this retrospective study, we evaluated the incidence and clinical signs of these two processes as defined by histological criteria. In 103 patients studied, nine (8.8%) had venoocclusive disease and 23 (22.5%) had nodular regenerative hyperplasia. Venoocclusive disease was significantly associated with transplantation for malignancy other than acute or chronic leukemia and use of busulfan as a cytoreductive agent and occurred in younger patients. Nodular regenerative hyperplasia did not differ from the general transplant population in terms of underlying disease, cytoreductive regimen, graft vs. host disease prophylaxis or age. Both venoocclusive disease and nodular regenerative hyperplasia were associated with ascites. Venoocclusive disease had a poor prognosis, with eight of nine cases dying of or with venoocclusive disease, whereas no case of nodular regenerative hyperplasia died of liver disease and only 5 of 23 died with nodular regenerative hyperplasia. Using retrospective data, five of 11 patients fulfilling clinical criteria for the diagnosis of venoocclusive disease actually had nodular regenerative hyperplasia, as did all of nine patients fulfilling the criteria for "possible" venoocclusive disease. These results indicate that nodular regenerative hyperplasia is a process which occurs commonly following bone marrow transplantation and which may be clinically misdiagnosed as venoocclusive disease.
Pityrosporum ovale<i>(Malassezia furfur)</i>as the causative agent of seborrhoeic dermatitis: new treatment options
Authors: J. FAERGEMANN, T.C. JONES, O. HETTLER, Y. LORIA
Journal: British Journal of Dermatology (1996)

Journal Article Pityrosporum ovale (Malassezia furfur) as the causative agent of seborrhoeic dermatitis: new treatment options Get access J. FAERGEMANN, J. FAERGEMANN Department of Dermatology, Sahlgrenska University Hospital, Gothenburg, Sweden Dr J. Faergemann, Department of Dermatology, Sahlgrenska University Hospital, S‐413 45 Gothenburg, Sweden. Search for other works by this author on: Oxford Academic Google Scholar T.C. JONES, T.C. JONES Sandoz Pharma AG, Basel, Switzerland Search for other works by this author on: Oxford Academic Google Scholar O. HETTLER, O. HETTLER Sandoz Pharma AG, Basel, Switzerland Search for other works by this author on: Oxford Academic Google Scholar Y. LORIA Y. LORIA Sandoz SA, Rueil‐Malmaison, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 134, Issue s46, 1 June 1996, Pages 12–15, https://doi.org/10.1111/j.1365-2133.1996.tb15652.x Published: 01 June 1996
A study of cardiorespiratory dynamics with step and ramp exercise tests in normoxia and hypoxia
Authors: PHILIPPA C MURPHY, LEON A CUERVO, RICHARD L HUGHSON
Journal: Cardiovascular Research (1989)

The ability of the cardiorespiratory system to adapt to the demands of increased exercise intensity was studied under the effects of hypoxia with two different submaximal cycling exercise protocols. A step transition in work rate from 25 W to 105 W and a ramp increase in work rate from a baseline of 25 W with a slope of 40 W·min−1 were used. Eight healthy male subjects each completed maximal exercise tests to exhaustion, as well as six repetitions of the step and the ramp, during normoxia and during hypoxia (FIO2 = 14%, balance N2). o2 was measured breath by breath and cardiac output () was estimated beat by beat by impedance cardiography. Kinetic analyses of the o2 and data were performed to obtain the gain and the total lag time. With hypoxia, the gain of the o2 response was no different from normoxia, at 10.6(SEM 0.1) ml·min−1·W−1, but total lag time increased from 23.0(2.2) s to 32.5(2.6) s (p<0.05). In contrast, with ramp exercise there was a significant reduction in the gain or slope of the o2 response from 9.4(0.2) ml·min−1·W−1 in normoxia to 9.0(0.1) ml·min−1·W−1 in hypoxia, while total lag time was no different between normoxia and hypoxia, at 19.7(3.3) v 21.4(2.9) s. Both the gain and total lag time of the step tests were significantly different from the ramp test. Kinetics of during the step transition did not differ between normoxia and hypoxia, at 26.5(2.3) v 31.0(4.9) s, respectively (NS). Slower kinetics of o2 during the step increase in work rate appear to be caused by a reduction in arterial O2 content. The apparent lack of difference in the kinetics of o2 with hypoxia in the ramp exercise test is not a result of improved O2 transport. Rather, the reduction in the slope of the o2 versus time relationship shows a progressive inability to meet the metabolic demands by O2 transport. The ramp test protocol is not suited for the study of dynamic characteristics of the cardiorespiratory system.
Effect of Intensive Glycemic Lowering on Health-Related Quality of Life in Type 2 Diabetes
Authors: Roger T. Anderson, K.M. Venkat Narayan, Patricia Feeney, David Goff, Mohammed K. Ali, Debra L. Simmons, Jo-Ann Sperl-Hillen, Thomas Bigger, Robert Cuddihy, Patrick J. O'Conner, Ajay Sood, Ping Zhang, Mark D. Sullivan
Journal: Diabetes Care (2011)

To compare the effect of intensive versus standard glycemic control strategies on health-related quality of life (HRQL) in a substudy of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.
Short Hairpin RNA Interference Therapy for Ischemic Heart Disease
Authors: Mei Huang, Denise A. Chan, Fangjun Jia, Xiaoyan Xie, Zongjin Li, Grant Hoyt, Robert C. Robbins, Xiaoyuan Chen, Amato J. Giaccia, Joseph C. Wu
Journal: Circulation (2008)

Background— During hypoxia, upregulation of hypoxia inducible factor-1 alpha transcriptional factor can activate several downstream angiogenic genes. However, hypoxia inducible factor-1 alpha is naturally degraded by prolyl hydroxylase-2 (PHD2) protein. Here we hypothesize that short hairpin RNA (shRNA) interference therapy targeting PHD2 can be used for treatment of myocardial ischemia and this process can be followed noninvasively by molecular imaging. Methods and Results— PHD2 was cloned from mouse embryonic stem cells by comparing the homolog gene in human and rat. The best candidate shRNA sequence for inhibiting PHD2 was inserted into the pSuper vector driven by the H1 promoter followed by a separate hypoxia response element-incorporated promoter driving a firefly luciferase reporter gene. This construct was used to transfect mouse C2C12 myoblast cell line for in vitro confirmation. Compared with the control short hairpin scramble (shScramble) as control, inhibition of PHD2 increased levels of hypoxia inducible factor-1 alpha protein and several downstream angiogenic genes by &gt;30% ( P &lt;0.01). Afterward, shRNA targeting PHD2 (shPHD2) plasmid was injected intramyocardially following ligation of left anterior descending artery in mice. Animals were randomized into shPHD2 experimental group (n=25) versus shScramble control group (n=20). Bioluminescence imaging detected plasmid-mediated transgene expression for 4 to 5 weeks. Echocardiography showed the shPHD2 group had improved fractional shortening compared with the shScramble group at Week 4 (33.7%±1.9% versus 28.4%±2.8%; P &lt;0.05). Postmortem analysis showed increased presence of small capillaries and venules in the infarcted zones by CD31 staining. Finally, Western blot analysis of explanted hearts also confirmed that animals treated with shPHD2 had significantly higher levels of hypoxia inducible factor-1 alpha protein. Conclusions— This is the first study to image the biological role of shRNA therapy for improving cardiac function. Inhibition of PHD2 by shRNA led to significant improvement in angiogenesis and contractility by in vitro and in vivo experiments. With further validation, the combination of shRNA therapy and molecular imaging can be used to track novel cardiovascular gene therapy applications in the future.
PGClα-MEDIATED MITOFUSIN-2 DEFICIENCY IN PULMONARY ARTERIAL HYPERTENSION CAN BE REGRESSED BY PRO-FUSION AND ANTI-FISSION THERAPY
Authors: John Ryan, Glenn Marsboom, Yong Hu Fang, Peter Toth, Erik Morrow, Nancy Luo, Zhigang Hong, Kyle Ericson, Hannah Zhang, Chad Haney, Chin-Tu Chen, Willard Sharp, Stephen Archer
Journal: Journal of the American College of Cardiology (2013)
Delayed-Type Hypersensitivity Skin Testing Predicts Progression to AIDS in HIV-infected Patients
Authors: S P Blatt, C W Hendrix, C A Butzin, T M Freeman, W W Ward, R E Hensley, G P Melcher, D J Donovan, R N Boswell
Journal: Annals of Internal Medicine (1993)

Objective: To evaluate the prognostic significance of cutaneous delayed-type hypersensitivity (DTH) skin testing in persons infected with HIV. Design: Cohort study. Setting: United States Air Force (USAF) Medical Center. Patients: Consecutive sample of 889 HIV-infected USAF personnel or dependents undergoing their first staging evaluation from 1985 through August 1990 in the USAF HIV Natural History Study. Measurements: All patients were evaluated with DTH skin testing including purified protein derivative and four control skin test antigens: mumps, candida, tetanus toxoid, and trichophyton. In addition, all patients underwent CD4+ T-cell surface marker determinations. The relation between DTH skin test response at first evaluation and progression to Walter Reed stage 6 (presence of an AIDS-defining opportunistic infection) was evaluated using Kaplan-Meier survival analysis. Results: Patients with more than 400 CD4+T cells/mm3 are more likely than those having fewer than 400 CD4+T cells per mm3 to respond to at least one (94% compared with 67%, P < 0.001) or at least two (86% compared with 45%, P < 0.001) DTH skin tests. Mean CD4 counts are lower for anergic compared with nonanergic patients and for patients responding to a single control skin test compared with those responding to two or more skin tests (P < 0.05). The DTH skin test response at first evaluation was also found to predict progression to AIDS; the relative risk at 5 years of follow-up was 2.5 (95% CI, 1.2 to 5.2) for anergy compared with a single positive skin test and 3.0 (CI, 1.4 to 6.2) for a single compared with two or more skin test responses. The DTH skin test response at first evaluation was a predictor of progression (P < 0.001) when controlling for initial CD4 count and Walter Reed stage in a Cox proportional-hazards regression analysis. Conclusions: The DTH skin test response, a functional measure of cellular immunity, is an independent predictor of progression to AIDS in persons with HIV.
An appalling experience
Authors: R. Anwar
Journal: BMJ (2013)

Shortly after I stepped into the orthopaedic world, I faced one of the biggest challenges of my life. My uncle, who I lovingly called “Ammujan,” developed a rather unusual back pain.

Ammujan had looked after me since the death of my father. We enjoyed a very special relationship, and he had contributed significantly to my life in all respects.

I soon started doubting my diagnosis of mechanical back pain because his pain, if anything, was getting worse, despite him taking the …
Molecular Evidence for Increased Antitumor Activity of Gemcitabine by Genistein <i>In vitro</i> and <i>In vivo</i> Using an Orthotopic Model of Pancreatic Cancer
Authors: Sanjeev Banerjee, Yuxiang Zhang, Shadan Ali, Mohammad Bhuiyan, Zhiwei Wang, Paul J. Chiao, Philip A. Philip, James Abbruzzese, Fazlul H. Sarkar
Journal: Cancer Research (2005)

Abstract Soy isoflavone genistein exhibits growth inhibitory activity against human pancreatic cancer cell lines. We previously reported the potential of genistein to augment chemotherapeutic response of pancreatic cancer cells in vitro. In the present study, we investigated whether genistein pretreatment could be used as a novel strategy for gemcitabine-induced killing in vitro and enhanced antitumor activity in vivo using an orthotopic tumor model. We conducted our studies using paired isogenic human pancreatic cancer cell line with differences in metastatic behavior (COLO 357 and L3.6pl). In vitro studies were done to measure growth inhibition and degree of apoptotic cell death induced by either genistein alone, gemcitabine alone, or genistein followed by gemcitabine. Our results show that pretreatment of cells with genistein for 24 hours followed by gemcitabine resulted in 60% to 80% growth inhibition compared with 25% to 30% when gemcitabine was used alone. The overall growth inhibition was directly correlated with apoptotic cell death irrespective of the metastatic potential of cells. Several genes that are known to inhibit apoptosis and contribute to chemoresistance such as nuclear factor-κB (NF-κB) and Akt were assessed to investigate the basis for the observed chemosensitizing effects of genistein. Genistein potentiated the gemcitabine-induced killing by down-regulation of NF-κB and Akt. In contrast, Akt and NF-κB were found to be up-regulated when pancreatic cancer cells were exposed to gemcitabine alone, suggesting the potential mechanism of acquired chemoresistance. In addition to in vitro results, we show here for the first time, that genistein in combination with gemcitabine is much more effective as an antitumor agent compared with either agent alone in our orthotopic tumor model. But most importantly, our data also showed that a specific target, such as NF-κB, was inactivated in genistein-treated animal tumors and that gemcitabine-induced activation of NF-κB was completely inhibited in animal tumors treated with genistein and gemcitabine. These results provide strong molecular in vivo evidence in support of our hypothesis that inactivation of NF-κB signaling pathway by genistein could also abrogate gemcitabine-induced activation of NF-κB resulting in the chemosensitization of pancreatic tumors to gemcitabine, which is likely to be an important and novel strategy for the treatment of pancreatic cancer.
VENEREAL DISEASE CONTROL IN THE ARMY
Authors: WILLIAM F. SNOW
Journal: JAMA (1918)

Venereal diseases, according to Surgeon-General Gorgas,<sup>1</sup>are the greatest cause of disability in the Army and present the most serious communicable disease problem of the war. In meeting this large problem, the Army is aiming to get maximum results by applying basic epidemiologic principles through sound administrative measures and controlling its methods by the statistical study of results. <h3>EPIDEMIOLOGY</h3> Compared with most other communicable diseases, the venereal diseases are well understood. Their causative organisms have been discovered, and the methods of transfer of infection are thoroughly known. The three principal venereal diseases, syphilis, gonorrhea (including all gonococcus infections) and chancroid, are spread essentially by contact. The commonest manner of transfer is through sexual intercourse, and all the other ways of spread may well be regarded as incidental or secondary to transfer through promiscuous sex relations. As long as venereal diseases are prevalent there will be many infections through other
Safety and efficacy of bortezomib-melphalan-prednisone-thalidomide followed by bortezomib-thalidomide maintenance (VMPT-VT) versus bortezomib-melphalan-prednisone (VMP) in untreated multiple myeloma patients with renal impairment
Authors: Fortunato Morabito, Massimo Gentile, Carla Mazzone, Davide Rossi, Francesco Di Raimondo, Sara Bringhen, Roberto Ria, Massimo Offidani, Francesca Patriarca, Chiara Nozzoli, Maria Teresa Petrucci, Giulia Benevolo, Iolanda Vincelli, Tommasina Guglielmelli, Mariella Grasso, Roberto Marasca, Luca Baldini, Vittorio Montefusco, Pellegrino Musto, Nicola Cascavilla, Ignazio Majolino, Caterina Musolino, Michele Cavo, Mario Boccadoro, Antonio Palumbo
Journal: Blood (2011)
Failure of Exercise to Reduce Hypertension-Reply
Authors: William C. Siegel
Journal: JAMA (1992)

<h3>In Reply.</h3> —We share the concern that the conclusions of our study not be misinterpreted. A direct comparison between our study and that of Keleman et al<sup>1</sup>may not be appropriate because Keleman and colleagues did not include a nonexercising control group; therefore, it is impossible to separate the effects of exercise from other blood pressure lowering effects, such as regression to the mean, placebo, or nonspecific factors. We demonstrated the importance of controlling for study participation and attention for adequately interpreting treatment effects. A higher-intensity exercise program than the one we used may have been more effective at lowering blood pressure. Indeed, we reported a post hoc analysis suggesting that those patients with the greatest increase in aerobic fitness exhibited the greatest decrease in clinic diastolic blood pressure. Although Keleman et al claim that their subjects exercised at 80% to 85% of maximum, compared with 70% to 75%
Experience With Vena Caval Filter Migration
Authors: Richard D. Sautter
Journal: JAMA (1972)

To the Editor.—  The Mobin-Uddin vena caval umbrella filter for preventing recurrent pulmonary embolism does not require general anesthesia. However, this distinct advantage is offset by the filter's distressing tendency to migrate. The latest report (Edwards Laboratories, written communication, Oct 1, 1971) states that 571 implantations have been followed by six reported cases of migration. Whether all migrations have been reported is not known. Of the five instances investigated, two occurred immediately after implantation, and the other three instances 4, 36, and 48 hours later. Three of the five patients died.  When a vena caval umbrella filter migrates and threatens to embolize, it may be worthwhile attempting to push the loose filter down with a second and, by so doing, trap the loose filter. In the following case, implanting a second filter apparently prevented catastrophic migration of the initial filter into the pulmonary artery.  Report of a Case.—  On July