tbuckley/cabot-search huggingface dataset:
FURTHER OBSERVATION ON THE TREATMENT OF THE ABDOMINAL VISCERA THROUGH THE COLON.
Authors: FENTON B. TURCK
Journal: JAMA (1900)

In a paper on this subject, before theAmerican Medical Association, in June, 1899, I presented a summary of experiments on animals demonstrating the physiologic results of certain methods of treatment applied to the colon.<sup>1</sup>It was there shown that the introduction of small quantities of water at a temperature of 55 C.-131 F.—through the rectum into the colon produced marked effect not only on the abdominal organs but also on the heart and general circulation. These experiments and the results of clinical observation along lines indicated by them demonstrate, in a variety of cases, the great value of the procedure. In connection with these experiments and resultant clinical data, the present communication proposes to discuss other methods of colonic therapeusis original with myself. In the first of these new methods, air—hot or cold-is forced into the colon through a double tube, and allowed to escape. This hot or
A new Cross-Reaction Between Streptococci and Human Connective Tissue.
Authors: John I. Sandson
Journal: Annals of Internal Medicine (1968)

s1 May 1968A new Cross-Reaction Between Streptococci and Human Connective Tissue.John I. Sandson, M.D., David Hamerman, M.D.John I. Sandson, M.D.Search for more papers by this author, David Hamerman, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1176_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptImmune mechanisms following a streptococcus infection are thought to initiate acute rheumatic fever, although the nature of these events are not understood. Of great importance is the demonstration of cross-reactivity between components of the streptococcus and cardiac myofibrils or glycoproteins. This report describes an immunologic relation between streptococcal hyaluronate and proteinpolysaccharides of connective tissue. Human cartilage proteinpolysaccharides contains at least two antigenic components: one is species specific; the other is present in cartilage proteinpolysaccharides from many different species (human, cow, pig, shark, etc.). Hyaluronateprotein isolated from human synovial fluid cross-reacts with the common site of cartilage proteinpolysaccharides. With this information... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1176-1176KeywordsAntigensCartilageConnective tissueGlycoproteinsProteinsRheumatic feverStreptococcal infectionsStreptococcusSynovial fluid Issue Published: 1 May 1968 PDF DownloadLoading ...
Nurse Practitioner Redux
Authors: Catherine D. DeAngelis
Journal: JAMA (1994)

FOR those of us who were involved with the early nurse practitioner (NP) movement, the recent expansive embracing of advanced practice nurses is at once gratifying and thought provoking. It will be interesting to see if history repeats itself and NPs will continue to provide only a small proportion of primary care to Americans. I hope this will not be the case and that NPs soon will play a significant role in primary care. To assure the success of NPs, we might learn some valuable lessons from history. <h3>History</h3> As a nurse who had gone on to medical school and training in general pediatrics, I held the firm belief that the maldistribution of health care in this country could be resolved if nurses, with additional clinical training, would work with physicians as teams providing primary care. The work of Drs Henry K. Silver (a physician) and Loretta C. Ford (a
Relation of myocardial histomorphometric features and left ventricular contractile reserve assessed by high‐dose dobutamine stress echocardiography in patients with idiopathic dilated cardiomyopathy
Authors: Petar Otašević, Zoran B. Popović, Jovan D. Vasiljević, Radislav Vidaković, Lorenza Pratali, Alja Vlahović, Aleksandar N. Nesšković
Journal: European Journal of Heart Failure (2004)
THE APPLICATION OF NEGATIVE PRACTICE TO SPASMODIC TORTICOLLIS
Authors: STEWART AGRAS, CARLTON MARSHALL
Journal: American Journal of Psychiatry (1965)

A clinical study of the experimental application of negative practice to two cases of torticollis was reported. Several findings of previous workers were confirmed, including recovery in one case documented both clinically and by electromyography and followed up over a period of 22 months, no evidence of symptom substitution being found. Reasons for the failure of the second case were suggested and discussed.
Frequency determines defaults in German: Default perfect <i>-t</i> versus irregular plural <i>-s</i>
Authors: Joseph Paul Stemberger
Journal: Behavioral and Brain Sciences (1999)

The German facts are consistent with the hypothesis that the default is the most frequent allomorph. Plural -s is the least frequent allomorph and does not act as a default. There is another way to measure the frequency of perfects in which no single -n allomorph is as frequent as -t. Lexical versus computational components do not correlate with regularity.
Sharing Data and Experience: Using the Clinical and Translational Science Award (CTSA) “Moral Community” to Improve Research Ethics Consultation
Authors: Maureen Kelley, Kelly Fryer-Edwards, Stephanie M. Fullerton, Thomas H. Gallagher, Benjamin Wilfond
Journal: The American Journal of Bioethics (2008)

We face significant challenges in the translation of basic biomedical research into meaningful improvements in patients' health, moving research from “bench to bedside.” The federal government's ne...
Treatment of Chronic Atrial Fibrillation in Mitral Valvular Disease by Quinidine and by Direct Current Countershock: A Comparative Study.
Authors: John J. Kelly
Journal: Annals of Internal Medicine (1964)

s1 April 1964Treatment of Chronic Atrial Fibrillation in Mitral Valvular Disease by Quinidine and by Direct Current Countershock: A Comparative Study.John J. Kelly Jr., M.D., F.A.C.P., Arthur Selzer, M.D., F.A.C.P., Khodadad Keyani, M.D., William J. Kerth, M.D.John J. Kelly Jr., M.D., F.A.C.P.Search for more papers by this author, Arthur Selzer, M.D., F.A.C.P.Search for more papers by this author, Khodadad Keyani, M.D.Search for more papers by this author, William J. Kerth, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-714_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a series of 108 patients, with mitral stenosis, mitral regurgitation, or both, who underwent mitral valvular repair, chronic atrial fibrillation was treated by quinidine (75 cases) and by direct current countershock (33 cases). Quinidine therapy was administered in the immediate postoperative period (beginning 5 to 10 days after the operation) resulting in the conversion of 25 patients (33%) to sinus rhythm. Eighteen patients who could not be reverted to sinus rhythm at this time returned for another trial of quinidine therapy 2 to 4 months after the operation. In 7 of 18 subjects, sinus rhythm was restored (39%). In... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: John J. KellyJr., M.D., F.A.C.P.; Arthur Selzer, M.D., F.A.C.P.; Khodadad Keyani, M.D.; William J. Kerth, M.D.Affiliations: San Francisco, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1964Volume 60, Issue 4Page: 714-714KeywordsAtrial fibrillationMitral insufficiencyMitral stenosisValvular diseases ePublished: 1 December 2008 Issue Published: 1 April 1964 PDF downloadLoading ...
Proteinase 3 sidesteps caspases and cleaves p21Waf1/Cip1/Sdi1 to induce endothelial cell apoptosis
Authors: William F. Pendergraft, Earl H. Rudolph, Ronald J. Falk, Jennifer E. Jahn, Matthias Grimmler, Ludger Hengst, J. Charles Jennette, Gloria A. Preston
Journal: Kidney International (2003)
Tc-99m Red Blood Cell Imaging in a Patient With Blue Rubber Bleb Nevus Syndrome
Authors: Rajkumar Yarlagadda, Yusuf Menda, Michael M. Graham
Journal: Clinical Nuclear Medicine (2008)

Blue rubber bleb nevus syndrome, first discovered in 1860 by Gascoyen, is a rare syndrome characterized by multiple venous malformations (hemangiomas) of the skin and in the gastrointestinal tract. These hemangiomas may be found in the skin, GI tract, central nervous system, thyroid, parotid, eyes, oral cavity, musculoskeletal system, lungs, kidneys, liver, spleen, and bladder, and carry a significant potential for serious bleeding. We report a case of a 9-year-old patient who presented with bloody stools and was referred for localization of the bleeding site. A Tc-99m labeled red blood cell (RBC) scan showed no evidence of active lower GI bleeding but demonstrated multiple venous malformations throughout the body. Tc-99m labeled red blood cell imaging may be helpful to delineate the extent of involvement in patients with blue rubber bleb nevus syndrome.
Polycystic Ovaries and Coronary Artery Disease
Authors: Nancy M. McBride
Journal: Annals of Internal Medicine (1997)

Letters15 September 1997Polycystic Ovaries and Coronary Artery DiseaseNancy M. McBride, MDNancy M. McBride, MDLakewood, OH 44107Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-6-199709150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Birdsall and colleagues [1] recently discussed the association of polycystic ovaries and the extent of coronary artery disease in women having cardiac catheterization. They stated that anovulation with reduced estradiol production may be associated with coronary artery disease. However, elevated testosterone production seems to be one of the atherogenic influences in polycystic ovaries. As shown in their Table 2, the free testosterone values in women with polycystic ovaries were significantly greater than those in women with normal ovaries. This finding would also explain the diminished high-density lipoprotein cholesterol values found in women with polycystic ovaries. Estradiol levels ...References1. Birdsall MA, Farquhar CM, White HD. Association between polycystic ovaries and extent of coronary artery disease in women having cardiac catheterization. Ann Intern Med. 1997; 126:32-5. Google Scholar2. Polson DW, Adams J, Wadsworth J, Franks S. Polycystic ovaries-a common finding in normal women. Lancet. 1988; 1:870-2. Google Scholar3. Polson DW, Franks S, Reed MJ, Cheng RW, Adams J, James VH. The distribution of oestradiol in plasma in relation to uterine cross-sectional area in women with polycystic or multifollicular ovaries. Clin Endocrinol (Oxf). 1987; 26:581-8. Google Scholar4. Poretsky L. On the paradox of insulin-induced hyperandrogenism in insulin-resistant states. Endocr Rev. 1991; 12:3-13. Google Scholar5. Geffner ME, Kaplan SA, Bersch N, Golde DW, Landaw EW, Chang RZ. Persistence of insulin resistance in polycystic ovarian disease after inhibition of ovarian steroid secretion. Fertil Steril. 1986; 45:327-33. Google Scholar Author, Article, and Disclosure InformationAffiliations: Lakewood, OH 44107 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1997Volume 127, Issue 6Page: 491KeywordsAndrogensEstradiolHeart diseasesInsulin resistanceMedical risk factorsOral contraceptive therapyOvariesPregnancyStable coronary artery diseaseTestosterone Issue Published: 15 September 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effect of social deprivation on blood pressure monitoring and control in England: a survey of data from the quality and outcomes framework
Authors: M. Ashworth, J. Medina, M. Morgan
Journal: BMJ (2008)

<b>Objective</b> To determine levels of blood pressure monitoring and control in primary care and to determine the effect of social deprivation on these levels. <b>Design</b> Retrospective longitudinal survey, 2005 to 2007. <b>Setting</b> General practices in England. <b>Participants</b> Data obtained from 8515 practices (99.3% of all practices) in year 1, 8264 (98.3%) in year 2, and 8192 (97.8%) in year 3. <b>Main outcome measures</b> Blood pressure indicators and chronic disease prevalence estimates contained within the UK quality and outcomes framework; social deprivation scores for each practice, ethnicity data obtained from the 2001 national census; general practice characteristics. <b>Results</b> In 2005, 82.3% of adults (n=52.8m) had an up to date blood pressure recording; by 2007, this proportion had risen to 88.3% (n=53.2m). Initially, there was a 1.7% gap between mean blood pressure recording levels in practices located in the least deprived fifth of communities compared with the most deprived fifth, but, three years later, this gap had narrowed to 0.2%. Achievement of target blood pressure levels in 2005 for practices located in the least deprived communities ranged from 71.0% (95% CI 70.4% to 71.6%) for diabetes to 85.1% (84.7% to 85.6%) for coronary heart disease; practices in the most deprived communities achieved 68.9% (68.4% to 69.5%) and 81.8 % (81.3% to 82.3%) respectively. Three years later, target achievement in the least deprived practices had risen to 78.6% (78.1% to 79.1%) and 89.4% (89.1% to 89.7%) respectively. Target achievement in the most deprived practices rose similarly, to 79.2% (78.8% to 79.6%) and 88.4% (88.2% to 88.7%) respectively. Similar changes were observed for the achievement of blood pressure targets in hypertension, cerebrovascular disease, and chronic kidney disease. <b>Conclusions</b> Since the reporting of performance indicators for primary care and the incorporation of pay for performance in 2004, blood pressure monitoring and control have improved substantially. Improvements in achievement have been accompanied by the near disappearance of the achievement gap between least and most deprived areas.
Local hyperthermia benefits natural and experimental common colds.
Authors: D. Tyrrell, I. Barrow, J. Arthur
Journal: BMJ (1989)

OBJECTIVE--To determine whether inhaling fully humidified air at 43 degrees C gave more benefit to cold sufferers than inhaling air at 30 degrees C. DESIGN--Randomised double blind trial. Setting--General practice and the common cold research unit. SUBJECTS--87 Unselected patients with typical acute nasal and upper respiratory symptoms (general practice study), and 84 volunteers aged 18-50 without a history of chronic or allergic diseases. INTERVENTIONS--Subjects breathed from apparatus delivering 40 litres of room air heated to 43 degrees C or 30 degrees C and fully humidified (relative humidity 100%) per minute. End point--Reduction in severity of disease. MEASUREMENTS and main results--Patients recorded their symptoms (general practice study) and observers recorded symptoms and signs, weight of nasal secretions, isolation of virus, and antibody responses in volunteers. Patients treated for 20 minutes at 43 degrees C had in the succeeding days roughly half the score for symptoms of those treated at 30 degrees C. Volunteers treated for 30 minutes on three occasions when they were starting a cold showed an 18% [corrected] reduction in symptoms. Treatment of volunteers for 20 minutes at the onset of the cold and for 10 minutes on succeeding days showed no difference between 43 degrees C and 30 degrees C. CONCLUSIONS--Nasal hyperthermia can improve the course of a common cold and also give immediate relief of symptoms.
Physician Registration for Deceased Organ Donation
Authors: Alvin Ho-ting Li, Stephanie Dixon, Versha Prakash, S. Joseph Kim, Greg A. Knoll, Ngan N. Lam, Amit X. Garg
Journal: JAMA (2014)

A shortage of organs for transplant has prompted many countries to encourage citizens to register ("opt in") to donate their organs and tissues when they die. 1 However, less than 40% of the public is registered for organ donation in most countries with a registry. 1One common fear is that physicians will not take all measures to save the life of a registered citizen at a time of illness. 2 Showing that many physicians are registered for organ donation themselves could help dispel this myth.Although most physicians in surveys support organ donation, 3 whether they are actually registered remains unknown.Methods | We conducted a population-based cross-sectional study using linked health care databases from Ontario, Canada, as of May 17, 2013.We obtained a list of active physicians from the College of Physicians and Surgeons of Ontario (approximately 60% consented to release information for research). 4 This list was linked to the Institute for Clinical Evaluative Sciences physician database based on unique physician number and the Registered Persons Database based on first name, last name, and date of birth (90% linked).From these 2 data-
CONTROL AND SALE OF PROPRIETARY REMEDIES
Authors: SHIRLEY W. WYNNE
Journal: JAMA (1931)

One of the most baffling and serious problems confronting the regulation and control of drugs in any large city and, for that matter, in rural sections, is the suppression and elimination of falsely labeled and falsely advertised proprietary medicines and treatments. Time and again, various agencies, from city departments of health to the Federal Trade Commission, have through legislative or other action forced certain drugs or medicines out of existence, only to have them disconcertingly reappear, their composition in no manner changed, but their advertising cunningly contrived to evade the law.  Quacks and charlatans are notoriously skilful at misrepresentation. They have been quick to take advantage of every progressive development in advertising and psychology. The result is that today, despite national, state and local restrictions that have been devised to control charlatans and misrepresented proprietary mixtures, the problem is as great as ever. In fact there is an added complication
Case of Haemorrhage in one Lobe of the Cerebellum
Authors: E. Mackey
Journal: BMJ (1878)

got rid of a good deal of the poison, but still retained enough to nearly kill him.Slowly recovering from the effects of the mineral, he found that his syphilitic symptoms, which had been somewhat trou- blesome, had entirely disappeared; and, from that day to this, he has never detected a trace of the old malady.
Microtubule-Depolymerizing Agents Used in Antibody-Drug-Conjugates Induce Antitumor Activity by Stimulation of Dendritic Cells
Authors: K. Martin, P. Mueller, J. Schreiner, S. Theurich, S. Savic, D. Lardinois, V. Heinzelmann-Schwarz, D. Speiser, M. von Bergwelt-Baildon, A. Zippelius
Journal: Annals of Oncology (2014)
Angiocardiography with the Seven-Pinhole Collimator Evaluation of Methodology and Accuracy in Assessing Global and Regional Left Ventricular Function
Authors: RICHARD W. MYERS, RICHARD P. BAILS, V REDA REED, JOY M. PRICE, EDWARD DRASIN, J DANIEL HILL, J R SAPHIR
Journal: Clinical Nuclear Medicine (1982)

Determination of left ventricular function with tomographic radionuclide angiocardiography using a sevenpinhole collimator was evaluated by comparing results of invasive contrast studies and planar multigated blood pool imaging to the tomographic study of 25 patients. LAO, seven-pinhole multigated blood pool acquisition was reconstructed to produce eight slices from apex to base in each of eight segments of the cardiac cycle. After applying an edge detection routine, three-dimensional reconstruction of perimeters allowed cyclic viewing of the left ventricular angiogram in any projection. When planar and tomographic radionuclide techniques were compared to contrast studies, sensitivity and specificity for identification of segmental wall motion abnormalities were not different (93% and 90% for both). Ejection fraction was determined from tomography by integration of slices to produce a noncalibrated volume and from planar blood pool imaging and contrast ventriculograms by standard techniques. Ejection fraction as compared to contrast studies was accurately determined on the planar angiogram (R = .87, P < .001) with tomographic analysis showing similar significant correlation (R = .79, P < .001). Methodologic evaluation indicated that the tomographic study was readily positioned and acquired and provided the advantage of requiring little operator interaction. It suffers, however, from the disadvantage of long reconstruction times with current software and occasional difficulties in defining the superior extent of the left ventricle.
Biodistribution and pharmacokinetics of aerosol and intravenously administered dna–polyethyleneimine complexes: optimization of pulmonary delivery and retention
Authors: Nadezhda V Koshkina, Irina Y Agoulnik, Sara L Melton, Charles L Densmore, Vernon Knight
Journal: Molecular Therapy (2003)

This report describes the time-dependent biodistribution of human p53 plasmid delivered in aerosol with polyethyleneimine in mice compared to the distribution of this material following intravenous injection. Area-under-the-curve values for p53 plasmid after inhalation were 2.8-fold greater than values after intravenous administration, despite the fact that the delivered aerosol dose was one-fifth the intravenous dose. After aerosol administration, pulmonary concentrations of p53 plasmid were high and other organs showed amounts not distinguishable from untreated control. High concentrations of p53 plasmid in the lungs remained with negligible reduction for at least 24 h. Shortly after intravenous injection, organs exhibited the following relative levels of exogenously administered p53: liver > spleen > blood > or = lungs > heart > kidney. These results demonstrate effective pulmonary delivery of DNA in complex with PEI by aerosol, without significant systemic dissemination. In contrast, intravenous administration caused a prompt systemic distribution of DNA with a shorter half-life of the administered gene in the lungs.
Piecing Together the Puzzle of Severe Malaria
Authors: Aubrey J. Cunnington, Michael Walther, Eleanor M. Riley
Journal: Science Translational Medicine (2013)

Severe malaria manifests as several overlapping syndromes with high mortality. Interaction of parasites with endothelial protein C receptors and high parasite biomass have recently been identified as key determinants of severe disease. However, gaps in our understanding of severe malaria might hinder translation of these findings into new therapies.
Detection of a Rare Complication of Appendicitis by Scrotal Imaging
Authors: MARTIN CHARRON, JEFFREY B. MANDELL, GERALD M. KOLODNY
Journal: Clinical Nuclear Medicine (1988)

A case of a left scrotal abscess presenting as a mass in a patient after appendectomy is reported. Only two cases of this rare extra-abdominal complication have been described, but none have been previously reported in the radiologic literature. This abscess is assumed to have arisen secondary to a patent processus vaginalis. At autopsy, 15 to 37% of men have complete or partially processus vaginalis. Interestingly, the other reported cases ware also associated with a patent processus vaginalis.
Predictive value of low dose dobutamine transesophageal echocardiography and fluorine-18 fluorodeoxyglucose positron emission tomography for recovery of regional left ventricular function after successful revascularization
Authors: Frank M. Baer, Eberhard Voth, Hans J. Deutsch, Christian A. Schneider, Michael Horst, Ernst R. de Vivie, Harald Schicha, Erland Erdmann, Udo Sechtem
Journal: Journal of the American College of Cardiology (1996)