Aspirin and Renal Function
Authors: RICHARD S. MUTHER
Journal: Annals of Internal Medicine (1979)

Letters1 February 1979Aspirin and Renal FunctionRICHARD S. MUTHER, M.D., GEORGE A. PORTER, M.D., WILLIAM M. BENNETT, M.D.RICHARD S. MUTHER, M.D.Search for more papers by this author, GEORGE A. PORTER, M.D.Search for more papers by this author, WILLIAM M. BENNETT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-2-274_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with some concern the article by Kimberly and colleagues (1) stating that true glomerular filtration rate was depressed in patients with systemic lupus erythematosus taking aspirin. The article may be misleading in several respects.The most striking inconsistency appears when one analyzes the measurements of glomerular filtration rate. Although the mean value for inulin and creatinine clearance is only slightly different in the control period, impressive differences are evident when these measurements are compared in three of the six patients. Firm evidence exists supporting the good correlation between endogenous creatinine clearance and inulin clearance over...References1. KIMBERLYGILLBOWDENKEISERPLOTZ RJRHP: Elevated urinary prostaglandins and the effects of aspirin on renal function in lupus erythematosus. Ann Intern Med 89:336-341, 1978 LinkGoogle Scholar2. BENNETTPORTER WG: Endogenous creatinine clearance as a clinical measure of glomerular filtration rate. Br Med J 2:84-86, 1971 CrossrefMedlineGoogle Scholar3. DOOLANALPENTHEIL PEG: A clinical appraisal of the plasma concentration and endogenous clearance of creatinine. Am J Med 32:65-79, 1962 CrossrefMedlineGoogle Scholar4. ROPES M: Systemic Lupus Erythematosus. Cambridge, Massachusetts, Harvard University Press, 1976, p. 103 Google Scholar1. DONKERARISZBRENTJENSVAN DER HEMHOLLEMANS ALJGH: The effect of indomethacin on kidney function and plasma renin activity in man. Nephron 17:288-296, 1976 CrossrefMedlineGoogle Scholar2. ARISZDONKERBRENTJENSVAN DER HEM LAJG: The effect of indomethacin on proteinuria and kidney function in the nephrotic syndrome. Acta Med Scand 199:121-125, 1976 CrossrefMedlineGoogle Scholar3. ROSE G: Medical Research Council trials, in Glomerulonephritis, edited by KLUTHE R, VOGT A, BATSFORD SR. New York, John Wiley and Sons, 1977, pp. 174-182 Google Scholar4. BERGBERGAN KA: Effects of different doses of acetylsalicylic acid on renal function in the dog. Scand J Clin Lab Invest 36:779-786, 1976 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD S. MUTHER, M.D.; GEORGE A. PORTER, M.D.; WILLIAM M. BENNETT, M.D.Affiliations: University of Oregon Health Sciences Center Portland, OR 97201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1979Volume 90, Issue 2Page: 274-275KeywordsAspirinCreatinineGlomerular filtration rateLupus erythematosus ePublished: 1 December 2008 Issue Published: 1 February 1979 PDF downloadLoading ...