tbuckley/cabot-search huggingface dataset:
Abstract 3889: Cyclin-dependent kinase 4 levels affect the number of hair follicle stem cells in mouse epidermis
Authors: Sun Hye Kim, Everardo Macías, Christopher Sistrunk, Marcelo L. Rodriguez-Puebla
Journal: Cancer Research (2010)

Abstract The pRb/Cdk/cyclin/p16 pathway has been found altered in a majority of human neoplasias. In particular the Cyclin-dependent kinase 4 (CDK4) has been found mutated in familial melanoma, amplified or overexpressed in human gliomas, sporadic breast carcinomas and sarcomas. Additionally, a vast number of human cancers contain high levels of CDK4 activity due to loss of the Cdk inhibitor p16Ink4a or overexpression of its binding partner cyclin D1. We have previously demonstrated that CDK4 ablation inhibits chemically-induced mouse skin papillomas, whereas forced expression of CDK4 in mouse epidermis (K5-CDK4) accelerates malignant progression to Squamous Cell Carcinomas (SCC). However, the mechanisms by which changes in CDK4 expression levels control skin tumorigenesis have not been established. In this model topical application of DMBA and TPA results in clonal expansion of a slow cycling stem cell population localized at the bulge area of the hair follicle. Thus, we hypothesize that CDK4 deletion or overexpression affects tumorigenesis by altering the characteristic and/or the number of Keratinocytes Stem Cells (KSC). To address this, we employed the K15-EGFP transgenic mouse model, which expresses EGFP under the control of the keratin 15 promoter in the bulge area of the hair follicle, to generated K15-EGFP/K5-CDK4as well as K15-EGFP/CDK4−/− compound mice. Flow cytometry analysis of K15-EGFP/K5-CDK4 keratinocytes show 4-fold decrease in the number of KSC compared to K15-EGFP control mice. In contrast, K15-EGFP/CDK4−/− compound mice show 4-fold increase in the number of KSC compared with control siblings. Quantification of mRNA in the KSCs showed 3 to 5-fold increase in the CDK4 levels of KSC compared to non-Stem cell population, whereas mild or no changes in CDK2, Cyclin D1 and p27Kip1mRNA levels were detected. Consistent with these data, we also determined an increase number of Labeled-Retaining Cells (LRC) in the hair follicle of CDK4−/− and decreased LRC in K5-CDK4 mice. Together these results are consistent with our hypothesis that changes in CDK4 expression affects the asymmetric cell division of KSC population favoring an increase in the transit amplifying (TA) cell pool and decrease of the KSC pool in K5-CDK4 and the opposite in CDK4−/− mice. As a result, this model predicts that the number of transit amplifying or progenitor cells correlate with the susceptibility to papilloma development. Supported by NIH grant CA116328 Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3889.
FACTORS GOVERNING THE TREATMENT OF ASTHMA
Authors: J. ALEXANDER CLARKE
Journal: JAMA (1927)

My purpose is to give the results obtained in the cases reported in the papers of Dr. McLaughlin and of Dr. Stout. The treatment may be best described under four headings: specific, surgical, vaccine and drug. Specific treatment was given to all patients in whom positive skin reactions were obtained. Specific treatment consists in the elimination of the substance giving the skin reactions from the patients' surroundings, or in a series of hypodermic injections of the substance itself, designed to lower the patient's hypersensitiveness to the substance. This is known as hyposensitization, and it should be borne in mind that it is only partial and temporary and not curative. There are very definite limits to hyposensitization. For example, it is possible to treat a horse-sensitive individual so that he is able to ride horseback without any symptoms. Such a person, however, would not be able to spend his entire time
Contractility of the Hypertrophied Canine Heart in Chronic Volume Overload
Authors: M. Turina, W. D. Bussmann, H. P. Krayenbuhl
Journal: Cardiovascular Research (1969)

Journal Article Contractility of the Hypertrophied Canine Heart in Chronic Volume Overload Get access M. Turina, M. Turina From the Cardiovascular Department of the Medical Policlinic, Kantonsspital, Zürich, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar W. D. Bussmann, W. D. Bussmann From the Cardiovascular Department of the Medical Policlinic, Kantonsspital, Zürich, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar H. P. Krayenbühl H. P. Krayenbühl From the Cardiovascular Department of the Medical Policlinic, Kantonsspital, Zürich, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 3, Issue 4, October 1969, Pages 486–495, https://doi.org/10.1093/cvr/3.4.486 Published: 01 October 1969 Article history Received: 23 April 1969 Published: 01 October 1969
Transaminase Levels in Azotemia
Authors: BRUCE S. CHANG
Journal: Annals of Internal Medicine (1976)

Comments and Correction1 August 1976Transaminase Levels in AzotemiaBRUCE S. CHANG, M.D., REX V. BARNES, M.D., FRIEDRICH K. PORT, M.D.BRUCE S. CHANG, M.D.Search for more papers by this author, REX V. BARNES, M.D.Search for more papers by this author, FRIEDRICH K. PORT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-2-255_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the article by Cohen and associates in the March issue (Ann Intern Med84:275-280, 1976). This report, and others (1-3), establishes that markedly low serum glutamic oxalacetic transaminase (SGOT) levels are frequent occurrences among azotemic individuals. However, except in the report by Wolf and colleagues (1), azotemic sera assayed by a diazonium salt method have not shown low SGOT values (4, 5). This phenomenon has been reported mainly as occurring with the SMA 12/60 AutoAnalyzer (Technicon Instruments Corp., Tarrytown, New York) using a method based on ultraviolet absorption at 340 nM by NADH...References1. WOLFWILLIAMSCOPLON PDN: Low aspartate transaminase activity in serum of patients undergoing chronic hemodialysis. Clin Chem 18:567-568, 1972 CrossrefMedlineGoogle Scholar2. WARNOCKSTONEWAGNER LWC: Decreased aspartate aminotransferase ("SGOT") activity in serum of uremic patients. Clin Chem 20:1213-1216, 1974 CrossrefMedlineGoogle Scholar3. : Technicon Special Bulletin "SGOT Studies" 1973. Tarrytown, New York, Technicon Instruments Corp., 1973 Google Scholar4. KOKOTKUSKAKOZIAK FJH: Behavior of some plasma enzymes during extracorporeal hemodialysis. Acta Med Pol 8:461-466, 1967 MedlineGoogle Scholar5. BAILEYKATZHAMPERS GAC: Alterations in serum enzymes in chronic renal failure. JAMA 213:2263-2265, 1970 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Nephrology Department of Internal Medicine University Hospital The University of Michigan Medical Center Ann Arbor, MI 48104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPharmacologic profile of diaspirin cross-linked hemoglobin in hemodialysis patients 1 August 1976Volume 85, Issue 2Page: 255-256KeywordsAminotransferasesSaltsSerum glutamic oxaloacetic transaminase Issue Published: 1 August 1976 PDF downloadLoading ...
Dose adjustment in renal impairment: Response from <i>Martindale: the Complete Drug Reference</i>
Authors: Sean C Sweetman
Journal: BMJ (2005)

EDITOR—Vidal et al highlight some of the difficulties that Martindale: the Complete Drug Reference encounters in attempting to evaluate and summarise the published literature, including the licensed prescribing information issued in different countries (p 263).1

The variation in the details and recommendations is partly explained by the different primary purpose and audience of the publications studied. The British National Formulary ( BNF ) is probably the busy UK healthcare worker's first port of call and as such reflects current licensed prescribing information and expert opinion in the United Kingdom. I imagine that the same is true for the American Hospital Formulary System Drug Information ( AHFS Drug …
Abstract 14379: The Importance of the Muscle and Ventilatory Blood Pumps During Exercise, in Patients Without a Sub-pulmonary Ventricle (Fontan Operation)
Authors: Keri Shafer, Tony G Babb, David E Fixler, Benjamin Levine
Journal: Circulation (2011)

Purpose: To better understand the mechanism of stroke volume and cardiac output (Qc) change during exercise in patients with passive total systemic venous blood flow into the pulmonary circulation ...
Providing Primary General Medical Care in University Hospitals: Efficiency and Cost
Authors: Jacqueline Kosecoff, Robert H. Brook, Arlene Fink, Caren Kamberg, Carol Pindar Roth, George A. Goldberg, Lawrence S. Linn, Virginia A. Clark, Joseph P. Newhouse, Thomas L. Delbanco
Journal: Annals of Internal Medicine (1987)

Data on efficiency, costs, and profits of 15 internal medicine outpatient group practices in university hospitals were collected for 9 months from interviews, a time-motion study, observations, and reviews of bills. Charges for a follow-up visit were about 25% higher than Medicare's allowable charges, but differed threefold across practices. Physicians spent more than half their allocated patient care or supervision time in other activities and 14% of nursing time was used for direct patient care. Visits to second- and third-year residents cost one half of those to faculty. Faculty supervision of second- and third-year residents was limited; it was, on average, 2 minutes per follow-up visit. Despite these inefficiencies, bad debts, and educational costs, practices appeared to break even financially. We conclude it is financially feasible for university hospitals to provide primary care to disadvantaged populations.
Specific IgE and IgG antibody responses in children to timothy pollen components during immunotherapy
Authors: S. L. NORDVALL, B. RENCK, R. EINARSSON
Journal: Allergy (1989)

Fourteen children with timothy grass pollinosis were given immunotherapy (IT) for 3 years with a purified and characterized timothy grass pollen preparation or a crude aqueous timothy pollen extract. Crossed radioimmunoelectrophoresis (CRIE) showed that 75% of the children under 11 years of age developed new specificities of IgE antibodies against timothy antigens, in contrast to older children, where no development of IgE antibodies against new timothy antigens could be detected. IgE antibodies were only detected against antigens formerly known as allergens. Timothy‐specific IgG antibodies increased in most children during hyposensitization against the major allergens Ag 19 and Ag 24/25 and several other IgE‐binding timothy antigens.
TCT-495 Percutaneous, trans-endocardial injection of bone marrow derived mononuclear cells significantly improves left ventricular ejection fraction in patients following acute myocardial infarction: ALSTER Stem cell trial
Authors: Christian Heeger, Cuneo Alessandro, Schneider Carsten, Kai Jaquet, Karl-Heinz Kuck, Bergmann Martin
Journal: Journal of the American College of Cardiology (2012)
Inspiratory-to-Total Lung Capacity Ratio Predicts Mortality in Patients with Chronic Obstructive Pulmonary Disease
Authors: Ciro Casanova, Claudia Cote, Juan P. de Torres, Armando Aguirre-Jaime, Jose M. Marin, Victor Pinto-Plata, Bartolome R. Celli
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Static lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of lung hyperinflation as measured by the inspiratory capacity-to-total lung capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pulmonary disease (95% males; FEV(1), 1.17 L) with a mean follow-up of 34 months. We also compared the predictive value of IC/TLC with that of the BODE (body mass index, airflow obstruction, dyspnea, exercise performance) Index. Subjects who died (183; 27%) were older; had lower body mass index, FEV(1), and IC/TLC ratio; walked less in the 6-minute walking distance; and had more dyspnea, a higher BODE Index, and comorbidity (p < 0.001). On the basis of logistic regression analysis, IC/TLC was found to be a good and independent predictor of all-cause and respiratory mortality. On the basis of receiver operating characteristic Type II curves, IC/TLC compared favorably with FEV(1) and predicted mortality independently of the BODE Index. We conclude that IC/TLC is an independent risk factor for mortality in subjects with chronic obstructive pulmonary disease. We propose that this ratio be considered in the assessment of patients with chronic obstructive pulmonary disease.
Technological State of the Art, Possibilities and Trends in Urologic-Endoscopic Color Photo, Film and Video Recording Techniques
Authors: A. Gaca
Journal: Endoscopy (1980)

Endoscopic color photo-documentation has attained a high standard of sophistication through pioneering new technical developments and advances. Nearly all the cavities in the human body can be endoscopically explored by expediently combining appropriate equipment. Suitable endo-instruments for photography, film, and color video are discussed here on the basis of extensive experience at the German Diagnostic Clinic in Wiesbaden. The trand is clearly toward modern methods of magnetic tape recording employing compatible systems. A bright future is predicted for the color video process in medicine, especially in endoscopy.
Effects of propranolol therapy on platelet release and prostaglandin generation in patients with coronary heart disease.
Authors: J Mehta, P Mehta
Journal: Circulation (1982)

Suppression of platelet function is thought to be a mechanism of propranolol's beneficial action in angina pectoris. To study the effects of propranolol on platelets, we measured plasma beta thromboglobulin and plasma thromboxane B2 (TXB2, stable metabolite of TXA2) levels by radioimmunoassay as indexes of platelet alpha-granule and TXA2 release, respectively. Platelet TXA2 generation in vitro in response to arachidonate and thrombin was also quantitated. Twenty-nine patients with coronary disease -- 15 not taking propranolol (group A) and 14 taking propranolol (group B) -- and 15 normal subjects were studied. Plasma beta-thromboglobulin levels were increased in group A and B patients (mean 63 +/- 8 and 96 +/- 14 ng/ml, respectively) compared with normal subjects (mean 46 +/- 6 ng/ml). Plasma TXB2 levels were similar in group A and B patients and in normal subjects (mean 148 +/- 41, 149 +/- 36 and 216 +/- 39 pg/ml). Arachidonate-induced platelet TXA2 generation was significantly higher in group A patients than in normal subjects (725 +/- 393 vs 82 +/- 25 pg TXB2/10(8) platelets, p less than 0.001). In contrast, platelets from group B patients had very low TXA2 generation (mean 21 +/- 18 pg) compared with platelets from group A patients or normal subjects (p less than 0.001). Similar results were obtained using thrombin. These data show that propranolol therapy does not affect platelet-released beta thromboglobulin or TXA2 at rest, but significantly reduces the capability of platelets to generate TXA2 in vitro. Reduction in platelet TXA2 generation may be an important mechanism of action of propranolol in patients with coronary artery disease.
miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity
Authors: Nikolaos Mellios, Hiroki Sugihara, Jorge Castro, Abhishek Banerjee, Chuong Le, Arooshi Kumar, Benjamin Crawford, Julia Strathmann, Daniela Tropea, Stuart S Levine, Dieter Edbauer, Mriganka Sur
Journal: Nature Neuroscience (2011)
Prenatal diagnosis requests for Huntington's disease when the father is at risk and does not want to know his genetic status: clinical, legal, and ethical viewpoints
Authors: R. Tassicker
Journal: BMJ (2003)

<i>Clinical genetics units of hospitals occasionally receive requests from women for prenatal diagnosis for Huntington9s disease when their male partners are at risk and do not want to know their genetic status for the disease. These cases raise significant legal and ethical concerns for the clinical team because such prenatal tests can reveal that the woman9s partner has the genetic mutation for Huntington9s disease when he does not want this information and may be unprepared for it. In this paper we present clinical, legal, and ethical appraisals of this situation. We conclude that there is no easy answer to such requests and that clinical teams need to deal with them on the basis of the individual circumstances</i>
Diffuse Fasciitis and Eosinophilia with Symmetric Polyarthritis
Authors: Jerome Rosenthal, Merrill D. Benson
Journal: Annals of Internal Medicine (1980)

Articular involvement has been infrequently reported in diffuse fasciitis with eosinophilia. We report a patient with diffuse fasciitis with eosinophilia, concurrent symmetrical polyarthritis, and bilateral carpal tunnel syndrome. Light microscopy and immunofluorescence studies of synovium and full-thickness calf biopsy were done. Synovial fluid analyses showed mildly inflammatory fluid. Response to prednisone, clinically and by laboratory indicators, was prompt and dramatic.
Topiramate for the Treatment of Cocaine Addiction
Authors: Bankole A. Johnson, Nassima Ait-Daoud, Xin-Qun Wang, J. Kim Penberthy, Martin A. Javors, Chamindi Seneviratne, Lei Liu
Journal: JAMA Psychiatry (2013)

No medication has been established as an efficacious treatment for cocaine dependence. We hypothesized that dual modulation of the mesocorticolimbic dopamine system by topiramate-a glutamate receptor antagonist and γ-aminobutyric acid receptor agonist-would result in efficacious treatment for cocaine dependence compared with placebo.To determine the efficacy of topiramate vs placebo as a treatment for cocaine dependence.Double-blind, randomized, placebo-controlled, 12-week trial of 142 cocaine-dependent adults in clinical research facilities at the University of Virginia between November 22, 2005, and July 25, 2011.Topiramate (n = 71) or placebo (n = 71) in escalating doses from 50 mg/d to the target maintenance dose of 300 mg/d in weeks 6 to 12, combined with weekly cognitive-behavioral treatment.For the efficacy period, weeks 6 to 12, the primary outcome was the weekly difference from baseline in the proportion of cocaine nonuse days; the secondary outcome was urinary cocaine-free weeks, and exploratory outcomes included craving and self- and observer-rated global functioning on the Clinical Global Impression scales.Using an intent-to-treat analysis, topiramate was more efficacious than placebo at increasing the weekly proportion of cocaine nonuse days, irrespective of whether missing data were not or were imputed conservatively to the baseline value (13.3% vs 5.3%, 95% CI for the estimated mean difference, 1.4%-14.6%, P = .02 or 8.9% vs 3.7%, 95% CI for the estimated mean difference, 0.2%-10.1%, P = .04, respectively). Topiramate also was associated, significantly more than placebo, with increasing the likelihood of urinary cocaine-free weeks (16.6% vs 5.8%; odds ratio, 3.21; 95% CI, 1.24-8.32; P = .02), as well as decreasing craving and improving observer-rated global functioning (all P < .05).Topiramate is more efficacious than placebo at increasing the mean weekly proportion of cocaine nonuse days and associated measures of clinical improvement among cocaine-dependent individuals.
INTERNS, RESIDENTS, AND JOHN Q. PUBLIC
Authors: Leland S. McKittrick
Journal: JAMA (1962)

As stated elsewhere in this issue (p. 389) by Dr. Kurt W. Deuschle, "The major purpose of medical education is to educate all types of physicians needed to provide medical services to society...." The recent explosion in developments in medical knowledge and techniques, however, has tremendously increased the difficulties in maturing the educational processes necessary to bring to the public the many benefits of these advances. The much-discussed doctor shortage, the acknowledgedly long and costly preparation for medical practice, the frequently expressed concern over the decreasing number of highly qualified applicants to our present schools, the large number of internships and the too few new graduates to fill them, and the continuing popularity of the specialties as opposed to family practice, give cause for deep concern about present concepts and methodologies and suggest the need for a thoughtful, unprejudiced, and imaginative look at our entire educational program. The points considered
Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development
Authors: Hiroshi Kawabe, Antje Neeb, Kalina Dimova, Samuel M. Young, Michiko Takeda, Shutaro Katsurabayashi, Miso Mitkovski, Oxana A. Malakhova, Dong-Er Zhang, Masato Umikawa, Ken-ichi Kariya, Sandra Goebbels, Klaus-Armin Nave, Christian Rosenmund, Olaf Jahn, JeongSeop Rhee, Nils Brose
Journal: Neuron (2010)
Platelet studies in patients with hypertrophic cardiomyopathy
Authors: R YAROM, B S LEWIS, G LIJOVETZKY, Y HAVIVI, J A CHANDLER
Journal: Cardiovascular Research (1982)

Because of a shared abnormality of platelet and muscle in some neuromuscular diseases, platelets were investigated in five cases of hypertrophic cardiomyopathy, a disease likely to be primarily myogenic. Morphometric and chemical differences from normal were found consisting of increased cell size, decreased phosphorus concentrations and increased permeability to cations. The findings suggest membrane and energy metabolism aberrations.
MCP-1 and EGF renal expression and urine excretion in human congenital obstructive nephropathy
Authors: Giuseppe Grandaliano, Loreto Gesualdo, Fabio Bartoli, Elena Ranieri, Raffaella Monno, Antonio Leggio, Guglielmo Paradies, Eustachio Caldarulo, Barbara Infante, F. Paolo Schena
Journal: Kidney International (2000)
901-23 Atrial Synchronous Versus AV Sequential Pacing for Hypertrophic Cardiomyopathy (HOCM)
Authors: Alan Micklin, Robert C. Sheppard, Robert Foley, Scott E. Hessen, Sina Zaim, Kevin D. Kravitz, Steven P. Kutalek
Journal: Journal of the American College of Cardiology (1995)
Increased Lipoprotein-Remnant Formation in Chronic Renal Failure
Authors: P. J. Nestel, N. H. Fidge, M. H. Tan
Journal: New England Journal of Medicine (1982)

Since accelerated atherosclerosis may be induced by excess circulating remnants of triglyceride-rich lipoprotein catabolism, we looked for evidence of remnant particle accumulation in the lipoproteins of 11 patients on long-term dialysis. We found several abnormalities in lipoprotein protein and lipids: enrichment of intermediate-density lipoproteins (IDL) and low-density lipoproteins (LDL) with triglyceride; the presence of apoprotein B48 (a "marker" for intestinal lipoproteins) in very-low-density lipoproteins (VLDL); an increased concentration of apoprotein AIV (a protein related to chylomicron transport); the presence of AIV in VLDL, IDL, and LDL; and the presence in LDL of apoproteins C and E (proteins not normally found in LDL). These findings strongly suggest accumulation of remnants of triglyceride-rich lipoproteins in patients with chronic renal failure who are undergoing peritoneal dialysis or hemodialysis, and may explain in part the increased incidence of coronary deaths among these patients. (N Engl J Med. 1982; 307:329–33.)