tbuckley/cabot-search huggingface dataset:
Abstract 4312: Identification of putative stem cell markers of CD133 and CD44 in human ovarian cancer specimens and ovarian cancer cell lines
Authors: Guiqin Sun, Fanliang Meng, Zhong Li, Changping Zou, Molly A. Brewer
Journal: Cancer Research (2010)

Abstract Objective: Ovarian cancer may arise from a subpopulation of CD133+ 44+ cells, which are self-renewing tumor-initiating cells. Materials and Methods: We investigated the tumorigenicity of the cell line A2780 which is CD133high44low, the cell line A2780 with siRNA against CD133 (CD133low44low), and human ovarian cancer cells from ascites, from primary ovarian cancer, and from metastatic ovarian cancer (CD133 high/CD44high) harvested from patients at the time of surgical cytoreduction in ultra low attachment plates in serum free medium. Spheroids from each of these sources were used to test their tumorigenicity in SCID mice. Results: Cells from A2780 cell line (CD133 high/CD44low) formed tumors in SCID mice in 2 months but silencing CD133 with siRNA CD133 (CD133 low/CD44low) inhibited tumorigenicity in SCID mice and retarded but did not prevent spheroid formation. Spheroid cultures of ascites, primary ovary, and metastasis (CD133 high/CD44high) are capable of inducing primary ovarian tumors and metastatic tumors in SCID mice in 2 months compared to 4-6 months in sorted, non-spheroid cells. Conclusions: The data suggest that CD133 expression is necessary for tumorigenesis in the A2780 cell line but not for spheroid formation. Our data also suggests that spheroids which are CD133 high/CD44high from human tumor recapitulate ovarian cancer in women. These novel in vivo and vitro models may offer useful tools to develop therapies targeted to ovarian cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4312.
Cannabinoids for Cancer Treatment: Progress and Promise
Authors: Sami Sarfaraz, Vaqar M. Adhami, Deeba N. Syed, Farrukh Afaq, Hasan Mukhtar
Journal: Cancer Research (2008)

Abstract Cannabinoids are a class of pharmacologic compounds that offer potential applications as antitumor drugs, based on the ability of some members of this class to limit inflammation, cell proliferation, and cell survival. In particular, emerging evidence suggests that agonists of cannabinoid receptors expressed by tumor cells may offer a novel strategy to treat cancer. Here, we review recent work that raises interest in the development and exploration of potent, nontoxic, and nonhabit forming cannabinoids for cancer therapy. [Cancer Res 2008;68(2):339–42]
The Bag320 satellite DNA family in Bacillus stick insects (Phasmatodea): different rates of molecular evolution of highly repetitive DNA in bisexual and parthenogenic taxa
Authors: B. Mantovani, F. Tinti, L. Bachmann, V. Scali
Journal: Molecular Biology and Evolution (1997)

The Bag320 satellite DNA (satDNA) family was studied in seven populations of the stick insects Bacillus atticus (parthenogenetic, unisexual) and Bacillus grundii (bisexual).It was characterized as widespread in all zymoraces of 23. atticus and in all subspecies of B. grandii.The copy number of this satellite is higher in the bisexual B. grundii (15%-20% of the genome) than in the parthenogenetic B. utticus (2%-5% of the genome).The nucleotide sequences of 12 Bug320 clones from B. utticus and 17 from B. grundii differed at 13 characteristic positions by fixed nucleotide substitutions.Thus, nucleotide sequences from both species cluster conspecifically in phylogenetic dendrograms.The nucleotide sequences derived from B. grundii grundii could be clearly discriminated from those of B. grandii benazzii and B. grandii maretimi on the basis of 25 variable sites, although all taxa come from Sicily.In contrast, the Bug320 sequences from B. atticus could not be discriminated accordingly, although they derive from geographically quite distant populations of its three zymoraces (the Italian and Greek B. utticus utticus, the Greek and Turkish B. utticus curius, and the Cyprian B. utticus cyprius).The different rate of evolutionary turnover of the Bug320 satDNA in both species can be related to their different modes of reproduction.This indicates that meiosis and chromosome segregation affect processes in satDNA diversification.
Inactivation of TP53 correlates with disease progression and low miR-34a expression in previously treated chronic lymphocytic leukemia patients
Authors: Annika Dufour, Giuseppe Palermo, Evelyn Zellmeier, Gudrun Mellert, Guillemette Duchateau-Nguyen, Stephanie Schneider, Tobias Benthaus, Purvi M. Kakadia, Karsten Spiekermann, Wolfgang Hiddemann, Jan Braess, Sim Truong, Nancy Patten, Lin Wu, Sabine Lohmann, David Dornan, Debraj GuhaThakurta, Ru-Fang Yeh, Galina Salogub, Philippe Solal-Celigny, Anna Dmoszynska, Tadeusz Robak, Marco Montillo, John Catalano, Christian H. Geisler, Martin Weisser, Stefan K. Bohlander
Journal: Blood (2013)
Increased progenitor cell proliferation in the peripheral blood of patients with bronchial asthma: The role of nitric oxide
Authors: Chun-Hua Wang, Wen-Yih Hsieh, Lee-Yung Shih, Horng-Chyuan Lin, Chien-Ying Liu, Kian Fan Chung, Han-Pin Kuo
Journal: Journal of Allergy and Clinical Immunology (1999)
IN-VITRO TEST OF HAPTOCORRIN DEGRADATION FOR BIOLOGICAL DIAGNOSIS OF EXOCRINE PANCREATIC DYSFUNCTION USING DUODENAL JUICE COLLECTED DURING ENDOSCOPY
Authors: Guéant Jl, Champigneulle B, Djalali M, Bigard Ma, Gaucher P, Hassouni A, Nicolas Jp
Journal: The Lancet (1986)
Intrathoracic impedance: A surrogate measure of fluid retention and predictor of hospitalization in patients with heart failure
Authors: Cheuk-Man Yu, Elaine Chau, Chu-Pak Lau, Wai-Fat Lam, Man-Oi Tang, Shun-Ling Kong, Qing Zhang, Hong Lin, Jill Christensen, Macrina Wong, Jenny Fong, Li Wang
Journal: Journal of the American College of Cardiology (2003)
Book Review Nuclear Medicine Edited by Robert E. Henkin, with six others. 1724 pp. in two volumes, illustrated. St. Louis, Mosby, 1996. $275. 0-8016-7701-7 Diagnostic Nuclear Medicine Third edition. Edited by Martin P. Sandler, R. Edward Coleman, Frans J.T. Wackers, James A. Patton, Alexander Gottschalk, and Paul B. Hoffer. 1547 pp. in two volumes, illustrated. Baltimore, Williams and Wilkins, 1996. $279. 0-683-07503-9
Authors: Leonard Rosenthall
Journal: New England Journal of Medicine (1996)
976-13 Autonomic Effects on Nodal Conduction as Assessed Before and After Radiofrequency Current Ablation in Patients with Atrioventricular Nodal Reentrant Tachycardia
Authors: Matthias Antz, Riccardo Cappato, Joachim Hebe, Christian Weiss, Thomas Meinertz, Karl-Heinz Kuck
Journal: Journal of the American College of Cardiology (1995)
Effect of parenteral amino acid supplementation in alcoholic hepatitis
Authors: Anna Mae Diehl, John K. Boitnott, H. Franklin Herlong, James J. Potter, Mary Ann Van Duyn, Elizabeth Chandler, Esteban Mezey
Journal: Hepatology (1985)

A controlled randomized study was performed in 15 patients with biopsy-proven alcoholic hepatitis to determine the effect of the administration of a parenteral amino acid-glucose solution for 1 month on nutritional, clinical, biochemical and histological parameters. All patients were allowed ad libitum consumption of a hospital diet. Five patients received the amino acid-glucose solution, while 10 received the glucose solution without amino acids. There was more improvement in nitrogen balance in the treated group than the control group. However, amino acid therapy was no more beneficial than control therapy in improving creatinine-height index, arm muscle area, arm fat area, and plasma levels of retinol binding proteins, prealbumin and pyridoxal-5′-phosphate. Clinical and biochemical markers of liver disease improved in both groups. This improvement in composite clinical index was more rapid in the treated than in the control group, but this early advantage was no longer apparent at the end of one month. Hepatocellular necrosis, inflammation and fat improved in the entire group. Amino acid treatment resulted in a greater resolution of fatty infiltration, but did not otherwise affect hepatic histology. Hepatocellular necrosis and inflammation in both the initial and final liver biopsies were highly correlated with nitrogen balance on admission. Initial clinical index correlated with the quantity of ethanol consumption prior to admission but not with liver injury on biopsy. However, by the end of the study, clinical index correlated with hepatocellular necrosis and inflammation. It is concluded that the clinical syndrome of alcoholic hepatitis is heavily influenced initially by metabolic consequences of alcohol consumption and that it is the resolution of this alcohol effect that is most influenced by parenteral amino acid supplementation.
MRK003, a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma
Authors: V Ramakrishnan, S Ansell, J Haug, D Grote, T Kimlinger, M Stenson, M Timm, L Wellik, T Halling, S V Rajkumar, S Kumar
Journal: Leukemia (2011)
Effect of donor age and sex on the outcome of liver transplantation*1
Authors: I MARINO
Journal: Hepatology (1995)

We correlated donor and recipient factors with graft outcome in 436 adult patients who underwent 462 liver transplants. Donor variables analyzed were age, gender, ABO blood group, cause of death, length of stay in the intensive care unit, use of pressors or pitressin, need for cardiopulmonary resuscitation, terminal serum transaminases, and ischemia time. Recipient variables analyzed were age, gender, primary diagnosis, history of previous liver transplant, ABO blood group, cytotoxic antibody crossmatch, United Network for Organ Sharing (UNOS) status, and waiting time (except for the cross-match results, they were all known at the time of the operation). The endpoint of the analysis was graft failure, defined as patient death or retransplantation. Using multivariate analysis, graft failure was significantly associated with donor age, donor gender, previous liver transplantation, and UNOS 4 status of the recipient. The effect of donor age became evident only when they were older than 45 years. Livers from female donors yielded significantly poorer results, with 2-year graft survival of female to male 55% (95% CI, 45% to 67%); female to female, 64% (95% CI, 54% to 77%); male to male, 72% (95% CI, 66% to 78%); and male to female, 78% (95% CI, 70% to 88%). The only donors identified as questionable for liver procurement were old (−60 years) women in whom the adverse age and gender factors were at least additive. However, rather than discard even these livers, in the face of an organ shortage crisis, their individualized use is suggested with case reporting in a special category.
Points from Letters: Fees for Certificates
Authors: W. J. J. Legg
Journal: BMJ (1971)

Analyzer.The conditions remained identical apart from increased concentration of indicator enzymes.3Normal ranges were determined for each system on blood drawn from healthy volunteers.The results are given in the Table .The range for asparate amino- transferase was much narrower with the LKB instrument, the upper limit of normal falling by 8 units.This was due to the standard deviation being virtually halved, since the mean was similar to the previous value.Instrument No.
Management of atrial fibrillation
Authors: C. Lafuente-Lafuente, I. Mahe, F. Extramiana
Journal: BMJ (2009)

#### Summary points

Atrial fibrillation is the commonest sustained arrhythmia encountered in clinical practice. Its prevalence increases with age, rising from 0.7% in people aged 55-59 years to 18% in those older than 85 years.1 Consequently, the public health burden associated with atrial fibrillation is increasing.w1 The therapeutics of atrial fibrillation is evolving. In recent years, publication of several randomised controlled trials and meta-analyses have improved our understanding of the advantages and inconveniences of rate and rhythm control strategies, and effective, new non-pharmacological treatments have been introduced. New antiarrhythmic and anticoagulant drugs are expected in the near future.

Atrial fibrillation is characterised by a chaotic electrical activity in the atria that induces an irregular and usually rapid contraction of the ventricles (figure 1⇓). Patients may be asymptomatic; may have mild symptoms, …
"Life Insurance Fees for Medical Touts."
Authors: George R. Shepherd
Journal: JAMA (1897)

Hartford, Conn., July 8, 1897. <h3>To the Editor:</h3> —Your edition of July 3 contains an editorial entitled "Life Insurance Fees for Medical Touts," which is in its initial statements so obviously unfair to the great majority of life insurance companies, as well as to the medical profession at large, that I beg leave to offer a remonstrance. You begin by saying, "for at least a half a century the American medical profession has been conscious of the great injustice done in the matter of fees for life insurance examinations." Now, I have been a practicing physician and life insurance medical examiner for thirty-one years, and for nearly half that time also the medical director of a large life insurance company. As the examiner of several companies I received, during the early part of my career, $3, and for the latter years $5, for each examination made, and when microscopic examination
RADIATION THERAPY IN CARCINOMA OF THE LUNG
Authors: WILLIAM V. TENZEL
Journal: JAMA (1941)

Radiation therapy for primary carcinoma of the lung has not been effective as a curative agent. However, its usefulness in palliation and in prolonging life should not be overlooked. Even in these spheres the value of radiation therapy has been challenged. Overholt<sup>1</sup>of the Lahey Clinic believes that radiotherapy shortens the life of patients with cancer of the lung; Portmann<sup>2</sup>of the Cleveland Clinic states that radiotherapy may result in symptomatic relief but not in prolongation of life, while Craver<sup>3</sup>of the Memorial Hospital, on the basis of 178 cases, reports that radiation therapy gives symptomatic relief and prolongs life. The present report based on an analysis of 192 treated and untreated primary carcinomas of the lung which had been examined post mortem at Montefiore Hospital from 1921 to 1939, demonstrates the value of radiation therapy in prolonging life. It was felt that autopsy material permitted a
Incidence and significance of mitral regurgitation following first myocardial infarction treated with rt-PA: Results fron TIMI II
Authors: Peter B. Berger, Nicholas A. Ruocco, Thomas J. Ryan, Daniel J. Diver, Margaret Frederick, Barry Sharaf, Frederick Felt, Michael J. Attubato, David P. Faxon
Journal: Journal of the American College of Cardiology (1991)
Abstract C42: Predicting prostate cancer aggressiveness and progression using a new quantitative nanoparticle assay
Authors: Qun Huo, Sally Litherland, David Decker
Journal: Cancer Research (2012)

Abstract Background: Over-diagnosis and treatment of prostate cancer has been a major problem in prostate cancer care and management. Currently the most relevant prognostic factor to predict a patient's risk of death due to prostate cancer is the Gleason score of the biopsied tissue samples. However, pathological analysis is subjective, and the Gleason score is only a qualitative estimate of the cancer malignancy. Molecular biomarkers and diagnostic tests that can accurately predict prostate tumor aggressiveness are rather limited. Method: We report here for the first time a nanoparticle test that not only can distinguish prostate cancer from normal and benign conditions, but also is capable of predicting the aggressiveness of prostate cancer quantitatively. To conduct the test, a prostate tissue lysate sample is spiked into a pure human IgG protein solution and the spiked sample is incubated with a citrate-protected gold nanoparticle solution. IgG is known to adsorb to citrate-protected gold nanoparticles to form a “protein corona” on the nanoparticle surface. From this study, we discovered that certain tumor-specific molecules can interact with IgG and change the adsorption behavior of IgG to the gold nanoparticles. This change is reflected in the nanoparticle size of the assay solution and detected by a dynamic light scattering technique. Assay data were analyzed by one-way ANOVA for multiple variant analysis, and using the Student t-test or nonparametric Mann–Whitney U-tests for pairwise analyses. Results: IgG solutions spiked with prostate tumor tissue exhibit significantly smaller nanoparticle size than the solutions spiked with normal and benign tissues. An inverse, quantitative correlation of the average nanoparticle size of the assay solution with tumor status and histological diagnostic grading was observed from the nanoparticle test. The higher grade the tumor is, the smaller the nanoparticle size is. The test particularly revealed large differences among the intermediate Grade 2 tumors, and suggested the necessity to treat them differently. Conclusion: The new nanoparticle test provides a quantitative measure of the prostate cancer aggressiveness. The test is easy to conduct, requires less than 5 μL of tissue lysate samples, and results are obtained in less than 10 minutes. It can be easily adapted for clinical application using the current needle-biopsy sampling system. This test will provide a more accurate tool to distinguish aggressive cancer from indolent tumor than the current diagnostic practices, if successfully validated by large cohort clinical studies. Citation Format: Qun Huo, Sally Litherland, David Decker. Predicting prostate cancer aggressiveness and progression using a new quantitative nanoparticle assay [abstract]. In: Proceedings of the AACR Special Conference on Advances in Prostate Cancer Research; 2012 Feb 6-9; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2012;72(4 Suppl):Abstract nr C42.
Apolipoprotein E Negatively Regulates House Dust Mite–induced Asthma via a Low-Density Lipoprotein Receptor–mediated Pathway
Authors: Xianglan Yao, Karin Fredriksson, Zu-Xi Yu, Xiuli Xu, Nalini Raghavachari, Karen J. Keeran, Gayle J. Zywicke, Minjung Kwak, Marcelo J. A. Amar, Alan T. Remaley, Stewart J. Levine
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Rationale: Distinct sets of corticosteroid-unresponsive genes modulate disease severity in asthma.Objectives: To identify corticosteroid-unresponsive genes that provide new insights into disease pathogenesis and asthma therapeutics.Methods: Experimental murine asthma was induced by nasal administration of house dust mite for 5 days per week. Dexamethasone and apolipoprotein E (apo E) mimetic peptides were administered via osmotic minipumps.Measurements and Main Results: Genome-wide expression profiling of the lung transcriptome in a house dust mite–induced model of murine asthma identified increases in apo E mRNA levels that persisted despite corticosteroid treatment. House dust mite–challenged apo E−/− mice displayed enhanced airway hyperreactivity and goblet cell hyperplasia, which could be rescued by administration of an apo E(130–149) mimetic peptide. Administration of the apo E(130–149) mimetic peptide to house dust mite–challenged apo E−/− mice also inhibited eosinophilic airway inflammation, IgE production, and the expression of Th2 and Th17 cytokines. House dust mite–challenged low-density lipoprotein receptor (LDLR) knockout mice displayed a similar phenotype as apo E−/− mice with enhanced airway hyperreactivity, goblet cell hyperplasia, and mucin gene expression, but could not be rescued by the apo E(130–149) mimetic peptide, consistent with a LDLR-dependent mechanism.Conclusions: These findings for the first time identify an apo E–LDLR pathway as an endogenous negative regulator of airway hyperreactivity and goblet cell hyperplasia in asthma. Furthermore, our results demonstrate that strategies that activate the apo E–LDLR pathway, such as apo E mimetic peptides, might be developed into a novel treatment approach for patients with asthma.
Grand Rounds on Medical Malpractice
Authors: James E. George
Journal: JAMA (1993)

<b>The Guide to Medical Professional Liability Insurance</b>, by Kirk B. Johnson, Martin J. Hatlie, and Ilene Davidson Johnson, 146 pp, paper, members $24, nonmembers $29, order No. OP631291CL, Chicago, Ill, American Medical Association, 1991. <i>Grand Rounds on Medical Malpractice</i>constitutes a thorough review of a number of important areas of medicolegal risk for the practicing physician. It is a comprehensive piece of work, in which the author, Francis X. Campion, MD, has marshaled articles by a number of authors published in various parts of the medical literature over the years. Some of the oldest material dates back to 1980 and, thus, raises the question whether more recent information should have been published when appropriate. The book contains a "publisher's commentary" by James S. Todd, MD, Executive Vice President of the American Medical Association. Dr Todd is well known for his malpractice expertise, dating back to when he chaired the Board
Gene-Expression Profiles in Hereditary Breast Cancer
Authors: I Hedenfalk, D Duggan, Y Chen, M Radmacher, M Bittner, R Simon, P Meltzer, B Gusterson, M Esteller, O P Kallioniemi, B Wilfond, A Borg, J Trent, M Raffeld, Z Yakhini, A Ben-Dor, E Dougherty, J Kononen, L Bubendorf, W Fehrle, S Pittaluga, S Gruvberger, N Loman, O Johannsson, H Olsson, G Sauter
Journal: New England Journal of Medicine (2001)

Many cases of hereditary breast cancer are due to mutations in either the BRCA1 or the BRCA2 gene. The histopathological changes in these cancers are often characteristic of the mutant gene. We hypothesized that the genes expressed by these two types of tumors are also distinctive, perhaps allowing us to identify cases of hereditary breast cancer on the basis of gene-expression profiles.