tbuckley/cabot-search huggingface dataset:
Hospital admissions for peptic ulcer during 1958-72.
Authors: R C Brown, M J Langman, P M Lambert
Journal: BMJ (1976)

Unpublished data from the Hospital In-patient Enquiry in England, Wales, and Scotland between 1958 and 1972 show that the frequency of admissions to hospital for peptic ulcer, particularly gastric ulcer, has fallen. This seems more likely to have been due to a true fall in the incidence of ulcer than to changes in treatment. Some three times as many people are admitted to hospital with duodenal ulcer in the north as in the south, but the frequency of admissions for gastric ulcer seems to vary little. The reasons for these differences are not understood.
Correlation of Secondary Cytogenetic Abnormalities With Histologic Appearance in Non-Hodgkin's Lymphomas Bearing t(14;18)(q32;q21)
Authors: J. O. Armitage, W. G. Sanger, D. D. Weisenburger, D. S. Harrington, J. Linder, P. J. Bierman, J. M. Vose, D. T. purtilo
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Correlation of Secondary Cytogenetic Abnormalities With Histologic Appearance in Non-Hodgkin's Lymphomas Bearing t(14;18)(q32;q21) Get access J. O. Armitage, J. O. Armitage Departments of Internal Medicine, University of Nebraska Medical Center42nd and Dewey Ave., Omaha, NE 68105 Search for other works by this author on: Oxford Academic PubMed Google Scholar W. G. Sanger, W. G. Sanger Pediatrics, University of Nebraska Medical Center42nd and Dewey Ave., Omaha, NE 68105 Search for other works by this author on: Oxford Academic PubMed Google Scholar D. D. Weisenburger, D. D. Weisenburger Pathology and Microbiology, University of Nebraska Medical Center42nd and Dewey Ave., Omaha, NE 68105 Search for other works by this author on: Oxford Academic PubMed Google Scholar D. S. Harrington, D. S. Harrington Pathology and Microbiology, University of Nebraska Medical Center42nd and Dewey Ave., Omaha, NE 68105 Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Linder, J. Linder Pathology and Microbiology, University of Nebraska Medical Center42nd and Dewey Ave., Omaha, NE 68105 Search for other works by this author on: Oxford Academic PubMed Google Scholar P. J. Bierman, P. J. Bierman Departments of Internal Medicine, University of Nebraska Medical Center42nd and Dewey Ave., Omaha, NE 68105 Search for other works by this author on: Oxford Academic PubMed Google Scholar J. M. Vose, J. M. Vose Departments of Internal Medicine, University of Nebraska Medical Center42nd and Dewey Ave., Omaha, NE 68105 Search for other works by this author on: Oxford Academic PubMed Google Scholar D. T. purtilo D. T. purtilo Pathology and Microbiology, University of Nebraska Medical Center42nd and Dewey Ave., Omaha, NE 68105 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 8, 15 June 1988, Pages 576–580, https://doi.org/10.1093/jnci/80.8.576 Published: 15 June 1988 Article history Received: 29 March 1988 Accepted: 31 March 1988 Published: 15 June 1988
The developmental progression from implicit to explicit knowledge: A computational approach
Authors: Martha Wagner Alibali, Kenneth R. Koedinger
Journal: Behavioral and Brain Sciences (1999)

Dienes &amp; Perner (D&amp;P) argue that nondeclarative knowledge can take multiple forms. We provide empirical support for this from two related lines of research about the development of mathematical reasoning. We then describe how different forms of procedural and declarative knowledge can be effectively modeled in Anderson's act-r theory, contrasting this computational approach with D&amp;P's logical approach. The computational approach suggests that the commonly observed developmental progression from more implicit to more explicit knowledge can be viewed as a consequence of accumulating and strengthening mental representations.
Letter: Correction of plasma calcium measurements.
Authors: A M Parfitt
Journal: BMJ (1974)

Jaundiced babies undergoing phototherapy often develop diarrhoea. The cause of it is still uncertain. Increasing evidence supports a role of a secretory mechanism for the diarrhoea. We therefore studied the effects of bile from congenitally jaundiced rats undergoing phototherapy and of unconjugated bilirubin on rat small intestine in vivo and in vitro. Results suggest that: (1) the bile from homozygous Gunn rats under phototherapy has an anti-absorptive effect when tested in the perfused jejunum of normal Wistar rats; (2) unconjugated bilirubin has a dose dependent secretory effect on the intestinal transport of water and electrolytes, when tested in the same system. Alteration of cyclic AMP or cyclic GMP, known intracellular mediators of secretion, was not observed. We conclude that free bilirubin is an intestinal secretagogue acting by an as yet unknown mechanism, that may mediate the secretory type of diarrhoea in jaundiced neonates undergoing phototherapy.
Clinical analysis of 100 medicolegal cases.
Authors: G Neale
Journal: BMJ (1993)

To find the reasons for legal claims against hospital doctors.Prospective analysis of requests for medical opinion submitted by solicitors during 1984-93 on legal claims against hospital doctors.100 successive cases: 98 from the United Kingdom and two from the Republic of Ireland.Principal underlying causes of claims.In 44 cases there was no serious clinical error. Of the 56 cases of clinical fault, seven were a failure of communication by doctors, 15 were an isolated error in otherwise good clinical management, 21 were errors that might not have occurred with better control of clinical practice (doctors exceeding their competence, poor clinical judgment, and poor teamwork), and 13 were major errors due to carelessness or incompetence. In 34 cases there was evidence of clinical fault that might escape clinical audit and medicolegal processes. Most of these legal claims have been or are likely to be withdrawn: only five plaintiffs have settled out of court, and 11 are pursuing their actions.To reduce the incidence of errors, hospital doctors should consult colleagues about difficult cases and specialists should maintain a broad interest in disease. The NHS clinical complaints procedure should be extended to cover potential claims, and serious cases should be subject to independent external assessment by experienced consultants.
A Correlative Study of FDG PET, MRI/CT, Electroencephalography, and Clinical Features in Subacute Sclerosing Panencephalitis
Authors: Kutluhan Yilmaz, Mustafa Yilmaz, Ahmet Mete, Zeki Celen
Journal: Clinical Nuclear Medicine (2010)

To describe F-18 fluorodeoxyglucose positron emission tomography (FDG PET) profile in patients with subacute sclerosing panencephalitis (SSPE) and to investigate its possible correlation with clinical, electroencephalography (EEG) or magnetic resonance imaging/computed tomography (MRI/CT) findings.EEG recording, MRI/CT and FDG PET imaging were performed in 16 patients with SSPE (1.9-15.6 years). FDG PET scans were assessed visually and in standardized uptake values. Finally, all the findings including clinical data were compared.MRI was abnormal in 10 patients. It was normal in 6 of 10 patients in earlier clinical stages. Nonspecific T2-weighted white matter findings were the most consistent MRI finding (10 patients). No thalamic lesion was detected in MRI/CT. FDG PET imaging was abnormal in 14 patients (8/10 patients in earlier stages). Glucose metabolism was decreased in thalamus, cerebellum or cerebral cortex in 12, 12, and 9 patients, respectively. Frontal cortex metabolism was preserved in earlier clinical stages. FDG PET imaging revealed putaminal hypermetabolism in 7 patients. However, MRI indicated striatal abnormality only in 2 patients with prolonged disease and later clinical stage. Three patients with putaminal hypermetabolism experienced a more rapid clinical deterioration. Onset age of SSPE, age of measles infection and EEG findings were not correlated with the imaging findings.Our findings suggest that FDG PET imaging can indicate affected brain regions in SSPE more confidently and earlier than MRI. FDG PET imaging would provide new insights into the pathogenesis of SSPE and help to develop new approaches to the patients with SSPE.
Accelerated purine nucleotide degradation by anaerobic but not by aerobic ergometer muscle exercise
Authors: Hisashi Yamanaka, Yasuhiro Kawagoe, Atsuo Taniguchi, Noboru Kaneko, Shin-ichi Kimata, Sa-ichi Hosoda, Naoyuki Kamatani, Sadao Kashiwazaki
Journal: Metabolism (1992)
P22. Immunomodulation induced by resveratrol or genistein on proliferation and apoptosis of tumour colon cells
Authors: L Brasoveanu, C Hotnog, M Bostan, G Matei, D Hotnog, M Gruia, M Mihaila
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Colon cancer represents a malignancy with a high incidence and mortality throughout the world, its etiology involving many genetic, immunological and biochemical factors. Anti-cancer drugs might exert their action during physiological pathways of apoptosis, leading to tumour cell
Ethics of a predictive test for Huntington's chorea.
Authors: S Thomas
Journal: BMJ (1982)

"Index Medicus" and 18 other publications have been consulted in an attempt to provide an easily assimilated selection of the recently published and widely dispersed material relevant to the ethical debate the editors of the "BMJ" called for on 4 March 1978. The medical profession is shown to be deeply divided on the ethics of a predictive test for Huntington's chorea. Some members are already using the prospect of a reliable test as an inducement to potential transmitters of this incurable hereditary disease to postpone procreation. Other members would prefer to see any future test withheld from every applicant until such time as radically improved means of treatment or a cure is discovered. The evolution of generally acceptable professional guidelines requires further informed debate.Genetic counseling for Huntington's chorea is discussed in terms of the psychological effect on those counseled and their relatives, the impact of counseling on reproduction rates, and the risks and benefits of a predictive test. Opinion polls on predictive testing have shown that many of those at risk believe that certainty about having the gene would be easier to bear than uncertainty. The desirable features of an ideal test are listed.
A CASE OF MULTIPLE LIPOMAS OF SYMMETRICAL DISTRIBUTION
Authors: Hilbert F. Day
Journal: JAMA (1923)

This case is reported (1) because of the symmetrical placement of lipomas, which showed a marked tendency to follow the paths of certain superficial nerves, and (2) because the distribution of the painful tumors was so characteristic of the typical von Recklinghausen's disease (generalized neurofibromatosis) that the histologic report of multiple lipomas was a surprise.  REPORT OF CASE  A car repairer, aged 30, and single, came to the surgical department of the Boston Dispensary, complaining of painful lumps on his arms, back and legs. His family history had no relation to his present condition. His habits were confined to the moderate use of tobacco and alcohol, except for an occasional excess in the latter. The patient's own history was unimportant, except that he said he had a complete right-sided neuritis at the age of 19, lasting two months, and characterized by dull pain on the affected side. This was not
Sylvia Annette Meakin Hatfield
Authors: M. Tompsett
Journal: BMJ (2012)

Sylvia Annette Meakin Hatfield (nee Herford) was unusual in her generation in being the daughter of a woman doctor. She and her husband, Ted, worked as family doctors in Ongar for nearly 40 years. They both had a particular interest in the psychological aspects of medicine and had met when they were both training to be psychiatrists in 1939. They used to go to the Tavistock Clinic, where Michael Balint, a Hungarian psychoanalyst, worked with groups of GPs to understand the interrelationship of psyche and soma. Sylvia did much maternity work, delivering babies in people’s homes. Family planning was an important part of her work and was linked to her strong social conscience and belief in …
Assessment of impact on health of residents living near the Nant-y-Gwyddon landfill site: retrospective analysis Commentary: Impact on health needs assessing from different angles
Authors: H M Fielder, C M Poon-King, S R Palmer, N Moss, G Coleman
Journal: BMJ (2000)

<h3>Abstract</h3> <b>Objectives:</b> To compare indices of health in a population living near a landfill site with a population matched for socioeconomic status and to review environmental monitoring data. <b>Design:</b> Ecological study with small area statistics and environmental reports. <b>Setting:</b> Electoral wards in valleys of South Wales. <b>Subjects:</b> Populations in the five wards near the landfill site who had formally complained of odours (exposed population), and comparison populations in 22 wards in the same unitary authority within the same fifth of Townsend score. <b>Outcome measures:</b> Mortality, rates of hospital admission, measures of reproductive health (proportion of all births and stillbirths of infants weighing &lt;2500 g; rates of admissions for spontaneous abortion; rates of all reported congenital malformations). Environmental data on site emissions. <b>Results:</b> There were no consistent differences in mortality, rates of hospital admissions, or proportion of low birthweight infants between the two populations. There was an increased maternal risk of having a baby with a congenital abnormality in residents near the site, both before its opening (relative risk 1.9; 95% confidence interval 1.3 to 2.85; P&lt;0.001) and after (1.9; 1.23 to 2.95; P=0.003). Environmental monitoring showed that hydrogen sulphide from the site was probably responsible for odours. <b>Conclusions:</b> The area surrounding the landfill site has an increased rate of reported congenital malformations, which predated the opening of the landfill, although the cluster of cases of gastroschisis postdated its opening. Several chemicals emitted from the site, including hydrogen sulphide and benzene, were found in air samples in the nearby community. Further studies of the reproductive risk in such communities are needed to examine the safety of waste disposal sites.
The influence of extracellular volume expansion on renal phosphate reabsorption in the dog
Authors: Shaul G. Massry, Jack W. Coburn, Charles R. Kleeman
Journal: Journal of Clinical Investigation (1969)

Extracellular volume expansion (ECVE) was produced, by normal saline infusion, in five normal and six thyroparathyroidectomized anesthetized dogs while glomerular filtration rate was reduced by the inflation of an intra-aortic balloon located above the renal arteries. The effect of ECVE on the maximum renal tubular reabsorptive capacity of phosphate (phosphate Tm) was also evaluated in five additional dogs. During ECVE, phosphate excretion increased both in normal and thyroparathyroidectomized dogs, and a direct and significant correlation was found between the fractional excretion of phosphate and sodium. Despite a substantial decrease in filtered phosphate which is produced by the acute reduction in glomerular filtration rate, phosphate excretion, during ECVE, exceeded control values. ECVE was associated with a reduction in phosphate Tm. The results demonstrate that ECVE increases phosphate excretion independent of changes in glomerular filtration rate and parathyroid gland activity. The data indicate that ECVE produced by saline infusion decreases the renal tubular reabsorption of phosphate.
Abstract 971: Identification of BCL6 targeted therapies for breast cancer through gene expression networks
Authors: Sarah R. Walker, Leandro C. Cerchietti, Maria C. Nicolais, Guo-Cheng Yuan, Ari Melnick, David A. Frank
Journal: Cancer Research (2012)

Abstract Breast cancer remains a deadly disease for countless women, thus new treatment strategies must be developed. Since inappropriate activation of transcription factors is a common pathogenic event in breast cancer, targeting these proteins may be a tractable new strategy. In particular, we have found that the BCL6 transcriptional modulator is expressed in 11 out of 12 breast cancer cell lines. In addition, BCL6 has been reported to be expressed in the majority of high-grade ductal carcinomas. Importantly, inhibiting BCL6 expression by RNA interference reduced cell survival. We hypothesized that BCL6 target gene expression profiles could be used to identify compounds with BCL6 inhibitory activity. To generate a breast cancer specific BCL6 gene signature, we employed the combination of gene expression microarrays and BCL6 binding sites identified by ChIP-seq in breast cancer cells. These BCL6 target gene profiles were then used to interrogate the Connectivity Map, a compilation of gene expression signatures reflecting the effects of more than 1300 compounds. This allowed us to identify compounds whose gene expression signature was the inverse of that mediated by BCL6, and might thereby function as BCL6 inhibitors. We screened six of these compounds for BCL6 inhibitory activity using a BCL6-specific reporter which identified disulfiram, celastrol, and harmol as inhibitors of the transcriptional repressor effects of BCL6. Importantly, treating breast cancer cells with these compounds reduced the viability of these cells. Moreover, combining these compounds with cytotoxic agents used in breast cancer therapy enhanced cell killing. In addition, combining these agents with a peptidomimetic of BCL6 also enhanced cell killing. Taken together, these studies show that BCL6 is a key therapeutic target in breast cancer, and that gene signature analysis can be used to identify novel inhibitors of this protein that have activity in breast cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 971. doi:1538-7445.AM2012-971
Psychosis due to "skunk"
Authors: A S Wylie, R T A Scott, S J Burnett
Journal: BMJ (1995)

EDITOR,--Recently we have become aware that drug misusers are using a variety of cannabis known as skunk. Some users have described a considerable psychotic experience after use of relatively small quantities.

In November 1994 we surveyed 50 drug misusers attending the methadone programme of the Glasgow drug problem service, asking them about their reported use and experiences of skunk. Eight …
Intracoronary beta-irradiation 24 hours after percutaneous coronary interventions: A serial volumetric intravascular ultrasound study
Authors: Christos S. Katsouras, Georgios E. Bozios, Lampros K. Michalis, John Kalef-Ezra, Dimitris Patsouras, Christos Pappas, Katerina K. Naka, John A. Goudevenos, Dimitris A. Sideris
Journal: Journal of the American College of Cardiology (2003)
Cause of Increase in Pneumonia.
Authors: J. N. Hurty
Journal: JAMA (1904)

Indianapolis, March 28, 1904. <h3>To the Editor:</h3> —A study of the Indiana mortality statistics and the morbidity and weather reports furnish data which seem to give some light on the cause of the recent marked increase in the pneumonia death rate. Comparing the periods made up of November and December, 1900, and January and February, 1901, as the first period, and November and December, 1903, and January and February, 1904, as the second period I find that in the first there were 1,720 deaths, the weather was not severe, measles, influenza and "colds" were very prevalent and natural gas with no smoke was the almost universal fuel. The weather being mild, and the use of soft coal, as suggested by Dr. Lindsley of Connecticut, were not the cause of the increase in pneumonia which appeared in the period named. In the second period there were 1,784 pneumonia deaths, only 64
Interaction between leukocytes and serum plasminogen: An essential mechanism in peripheral blood fibrinolytic activity
Authors: F. Ghezzo, P. Savoca, P. Vallero, G. Bellone
Journal: American Journal of Hematology (1986)

Abstract Intense fibrinolytic activity (FA) by granulocytes, mononuclear adherent cells, and natural killer (NK) cells was demonstrated by using 125 I‐fibrin‐coated wells. This FA was greatly dependent on serum plasminogen, provided that serum inhibitors were destroyed by heating at 56°C. Using monoclonal antibodies, it was also observed that these leukocytes produce urokinase and that this enzyme is secreted during adhesion by mononuclear adherent cells and during the cytotoxicity reaction against neoplastic cells by NK cells. Since cell intactness is necessary for leukocyte‐serum interaction, stress is placed on the membrane function. We conclude that leukocytes are essential in peripheral blood FA and that transport of urokinase by circulating cells, inside their cytoplasm, could offset its lack of affinity for fibrin and thus avoid undesirable systemic effects.
Hypoxaemia after Chest Injuries
Authors: P. D. Salpekar
Journal: BMJ (1964)

SIR,-As much as one would like to avoid a public controversy of the medico-political events in another part of the world one can- not let go unchallenged Lord Taylor's re- marks in your columns (18 January, p. 178).Lord Taylor regrets the split in the medical profession in this province between those who wish to practise medicine without Govern- ment interference and those working in com- munity health clinics.What he omits entirely to say is that only about 10% of physicians in community clinics are either Canadians or individuals who by virtue of having lived in Canada for a number of years have become part of the professional life of this country and province.The great majority of physi- cians practising in these clinics have been im- ports to Canada since the crisis of July 1962.
Splenic involvement by blastic mantle cell lymphoma (Large cell/anaplastic variant) mimicking splenic marginal zone lymphoma
Authors: M. Mollejo, E. Lloret, J. Solares, J.M. Bergua, M. Mateo, M.A. Piris
Journal: American Journal of Hematology (1999)

The most cases of splenic marginal zone lymphoma (SMZL) seem to respond favorably to splenectomy. The diagnosis of this lymphoma is mainly based on the recognition of a micronodular pattern of splenic involvement with marginal zone differentiation. However, it is possible to find so-called “marginal zone differentiation“ in splenic involvement by other small B-cell lymphomas, particularly mantle cell lymphoma (MCL) and follicular lymphoma. We report a case of blastic MCL, large cell/anaplastic variant with a high level of clinical aggressiveness, showing biphasic cytology and a micronodular pattern which resembles SMZL. A single biopsy corresponding to this case shows two phases of tumoral progression in a MCL, a rare finding in MCL. In conclusion, the differential diagnosis of SMZL must take the possibility of a blastic MCL with biphasic cytology into account, as the case here. Am. J. Hematol. 62:242–246, 1999. © 1999 Wiley-Liss, Inc.
Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment
Authors: Britta Will, Thomas O Vogler, Boris Bartholdy, Francine Garrett-Bakelman, Jillian Mayer, Laura Barreyro, Ashley Pandolfi, Tihomira I Todorova, Ujunwa C Okoye-Okafor, Robert F Stanley, Tushar D Bhagat, Amit Verma, Maria E Figueroa, Ari Melnick, Michael Roth, Ulrich Steidl
Journal: Nature Immunology (2013)