tbuckley/cabot-search huggingface dataset:
Abstract P1-06-02: A newly angiogenic biomarker Vasohibin-1 expression in ductal carcinoma in situ of the breast.
Authors: K Tamaki, N Tamaki, Y Kamada, K Uehara, M Miyashita, T Ishida, N Ohuchi, H Sasano
Journal: Cancer Research (2012)

Abstract Vasohibin-1 is a recently identified negative feedback regulator of angiogenesis induced by VEGF-A and bFGF. Our previous study was the first study demonstrating the status of vasohibin-1 in human breast lesions, which indicates that vasohibin-1 is associated with neovascularization and may especially play important roles in the regulation of intratumoral angiogenesis in human breast cancer. In this study, we first evaluated mRNA expression of vasohibin-1 and CD31 in 39 Japanese emale breast carcinoma specimens including 22 invasive ductal arcinoma (IDC) and 17 ductal carcinoma in situ (DCIS) using a real-time quantitative RT-PCR (QRT-PCR) with LightCycler system. Table shows the primer sequences used in real-time PCR in this study. In addition, we also immunolocalized vasohibin-1 and CD31 and compared their immunoreactivity to nuclear grades and histological grades of 100 carcinoma cases (50 IDC and 50 DCIS). There were no statistically significant differences of CD31 mRNA expression and the number of CD31 positive vessels between DCIS and IDC (P = 0.250 and P = 0.191, respectively), whereas there was a statistically significant difference in vasohibin-1 mRNA expression and the number of vasohibin-1 positive vessels in DCIS and IDC (P = 0.022 and P &amp;lt; 0.001, respectively). There was a significant positive correlation between vasohibin-1 mRNA level and Ki-67 labeling index in DCIS (r2 = 0.293, P &amp;lt; 0.001). In addition, vasohibin-1 mRNA expression was correlated with high nuclear and histological grades in DCIS cases and a significant positive correlation was detected between the number of vasohibin-1 positive vessels and Ki-67 labeling index or nuclear grade or Van Nuys classification of carcinoma cells (P &amp;lt;0.001, respectively). These results all indicate the possible correlation between aggressive biological features in DCIS including increased tumor cell proliferation and the status of neovascularization determined by vasohibin-1 immunoreactivity. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-06-02.
Community health services must be considered in proposals for integrated records
Authors: S Hume, P Robinson, R. Wrate, A Gowans, D Manders
Journal: BMJ (1999)

EDITOR—Rigby et al argue that without the sharing of clinical information it is difficult to achieve integrated care that focuses on the patient1; this undermines the effective functioning of extended primary care teams (however constituted) on which the NHS will increasingly depend. Our recent experience during a review of the primary care records of adolescents in Edinburgh suggests that attention should be paid to health professionals' skills and behaviour and to organisational factors.

We found that antenatal and birth data were generally missing from the …
453 Evaluation of cyclosporine peak level C2 target range in stable paediatric liver transplant recipients
Authors: S MAHEDEVAN, I VANMOURIK, P MCKIERNAN, S BEATH, D KELLY
Journal: Hepatology (2003)

1-Aryl-piperazine compounds are, depending on their substituents, selective for certain serotonin receptors and together with their easy availability and their so-called legal status, this group of psychoactive compounds are potential designer drugs-of-abuse. Internet in that respect is an important source of information and distribution facilities. Because this development may have consequences for the interpretation of future clinical and forensic toxicological case studies, some analytical aspects of 1-benzyl-piperazine (BZP), 1-[4-methoxyphenyl]-piperazine (pMeOPP) and 1-[3-trifluoromethylphenyl]-piperazine (TFMPP) were studied. BZP was not detected by the AxSYM® FPIA technology designed to determine amphetamine-like compounds, but had showed some cross reactivity with EMIT® d.a.u.®. The cross reactivities at 300 and 12,000 ng/ml (RS)-amphetamine equivalents were 0.4 and 1.3%, respectively. Although BZP was not identified directly by the REMEDi™ HS Drug Profiling System, it can be detected by this HPLC/UV scanning system. Using GC/NPD without derivatisation, BZP, pMeOPP and TFMPP can be analysed for and applying GC/MS without or with acetylation or trifluoroacetylation, these compounds can be identified unambiguously. The usefulness of GC/NPD and GC/MS in this respect was demonstrated by the quantitative and qualitative analysis of the content of a capsule with the synthetic stimulant A2, which proved to contain 86.4 mg of BZP.
Faisabilité, caractéristiques techniques, résultats et complications de la résection par mucosectomie endoscopique des polypes coliques et rectaux. Une série de 201 polypes consécutifs
Authors: M Antonietti, S Lecleire, E Ben Soussan, F Di Fiore, S Ramirez, F Lemoine, F Le Pessot, E Lerebours, P Ducrotté
Journal: Endoscopy (2008)

Introduction: La mucosectomie endoscopique (ME) est le traitement le plus habituel des polypes plans ou des volumineux polypes sessiles rectaux ou coliques. But: évaluer la faisabilité, les caractéristiques techniques, les résultats et les complications de la ME dans une grande série de polypes rectaux ou coliques.
Hypolipidemic Drugs in Coronary Artery Disease
Authors: William L. Isley
Journal: Annals of Internal Medicine (1997)

Letters1 June 1997Hypolipidemic Drugs in Coronary Artery DiseaseWilliam L. Isley, MDWilliam L. Isley, MDUniversity of Missouri-Kansas City, Kansas City, MOSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-11-199706010-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Pasternak and colleagues [1] address the important question of the need for combination therapy in patients with coronary heart disease and “normal” cholesterol values. However, they imply in their introduction and discussion that the amount of low-density lipoprotein (LDL) cholesterol lowering achieved is similar for all currently approved 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins). Specifically, the authors ignore the well-known dose-response curves of these agents, as shown in two studies they cite in their article. The EXCEL (Expanded Clinical Evaluation of Lovastatin) study [2] clearly shows that lovastatin has an increasing effect as doses are ...References1. Pasternak RC, Brown LE, Stone PH, Silverman DI, Gibson CM, Sacks FM. Effect of combination therapy with lipid-reducing drugs in patients with coronary heart disease and “normal” cholesterol levels. A randomized, placebo-controlled trial. The Harvard Atherosclerosis Reversibility Project (HARP) Study Group. Ann Intern Med. 1996; 125:529-40. Google Scholar2. Bradford RH, Shear CL, Chremos AN, Dujovne C, Downton M, Franklin FA, et al. Expanded Clinical Evaluation of Lovastatin (EXCEL) study results: I. Efficacy in modifying plasma lipoproteins and adverse event profile in 8245 patients with moderate hypercholesterolemia. Arch Intern Med. 1991; 151:43-9. Google Scholar3. Stein E, Kreisberg R, Miller V, Mantell G, Washington L, Shapiro DR, et al. Effects of simvastatin and cholestyramine in familial and nonfamilial hypercholesterolemia. Multicenter Group I. Arch Intern Med. 1990; 150:341-5. Google Scholar4. Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). JAMA. 1993; 269:3015-22. Google Scholar5. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease. The Scandinavian Simvastatin Survival Study (4S). Lancet. 1994; 344:1383-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Missouri-Kansas City, Kansas City, MO PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1997Volume 126, Issue 11Page: 916KeywordsCholesterolHigh density lipoproteinHypercholesterolemiaLipidsLow density lipoproteinMortalityNiacinStable coronary artery diseaseStatinsVery low density lipoprotein Issue Published: 1 June 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Reports: HIV Drugs Targeted for Black Market
Authors: Bridget M. Kuehn
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endothelium-Derived Neuregulin Protects the Heart Against Ischemic Injury
Authors: Nadia Hedhli, Qunhua Huang, April Kalinowski, Monica Palmeri, Xiaoyue Hu, Raymond R. Russell, Kerry S. Russell
Journal: Circulation (2011)

Background— Removal of cardiac endothelial cells (EC) has been shown to produce significant detrimental effects on the function of adjacent cardiac myocytes, suggesting that EC play a critical role in autocrine/paracrine regulation of the heart. Despite this important observation, the mediators of the protective function of EC remain obscure. Neuregulin (NRG, a member of the epidermal growth factor family) is produced by EC and cardiac myocytes contain receptors (erbB) for this ligand. We hypothesized that NRG is an essential factor produced by EC, which promotes cardioprotection against ischemic injury. Methods and Results— We demonstrate that human cardiac EC express and release NRG in response to hypoxia–reoxygenation. Under conditions where hypoxia–reoxygenation causes significant cardiac myocyte cell death, NRG can significantly decrease apoptosis of isolated adult ventricular myocytes. Coculturing adult murine myocytes with human umbilical vein, murine lung microvascular, or human coronary artery EC can also protect myocytes against hypoxia–reoxygenation–induced apoptosis. These protective effects are abolished by NRG gene deletion or silencing of NRG expression in EC. Finally, endothelium-selective deletion of NRG in vivo leads to significantly decreased tolerance to ischemic insult, as demonstrated by impaired postischemic contractile recovery in a perfused whole-organ preparation and larger infarct sizes after coronary artery ligation. Conclusion— Together, these data demonstrate that EC-derived NRG plays an important role in cardiac myocyte protection against ischemic injury in the heart and supports the idea that manipulation of this signaling pathway may be an important clinical target in this setting.
Management of open fractures of the lower limb
Authors: K. W Louie
Journal: BMJ (2009)

New guidelines emphasise collaborative working and early referral to specialist centres

The management of open fractures of the lower limb remains a challenge for both orthopaedic surgeons and reconstructive plastic surgeons. In the United Kingdom, about 15 open tibia fractures (shaft, plateau, and pilon) are treated at the average district general hospital serving a population of 25 000 each year, compared with 73 closed tibia fractures.1

Historically, most knowledge has been based on experience rather than evidence, and management has mainly been the remit of orthopaedic surgeons.2 Nowadays, several disciplines are involved in care including orthopaedic surgeons, plastic reconstructive and aesthetic surgeons, infectious disease specialists, and physiotherapists.

Few data are available on morbidity and mortality after open fractures, but prognosis has improved with the advent of antibiotics and rigid fixation in the mid-1970s.3 4 Subsequently, effective debridement, microvascular surgical techniques, and stabilisation of these fractures has improved salvage.5 6 7 Because the management of bone defects (bone loss at the time …
The Mental Health Comorbidities of Diabetes
Authors: Lee Ducat, Louis H. Philipson, Barbara J. Anderson
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Clinimetric Approach to the Components of the Patient-Physician Relationship
Authors: William H. Sledge
Journal: JAMA (1997)

Although patient-physician relationships have been expressed with diverse concepts and models, we have formulated a clinimetric classification derived from several years of observation and discussions at weekly housestaff conferences devoted to "difficult" patients. The observed phenomena are classified into the following components: (1) background factors intrinsic to patient and physician before they meet, (2) individual anticipations and hopes for what may happen, (3) extrinsic features of the setting, (4) individual reactions during the encounter, and (5) the consequences thereafter. These interacting components are usually too complex for characterizations based on single models for the relationship or single titles (such as "hateful" or "noncompliant") for the patient. The components can serve as a "review of systems" for identifying manifestations, sources, and solutions to such common problems as discordant hopes, the physician's unawareness of the patient's pertinent extramedicai status, psychiatric and mental-status challenges, and cogent factors in chronic illness.
PTU-038 Should a Plastic or a fully Covered Metal Stent be Placed at Index ERCP when a Patient Presents with Jaundice Due to a Malignant Distal Biliary Stricture?
Authors: D McClements, S Mahmood, P Whelan, E-E Psarelli, H L Smart, J Evans, M Lombard, S Sarkar
Journal: Gut (2013)

<h3>Introduction</h3> Traditionally plastic stents (PS) are inserted at the index ERCP to treat obstructive jaundice from malignant distal biliary strictures. However, with the development of fully covered metal stents (C-SEMS), this approach is now debated and practise at the Royal Liverpool Hospital (RLH) has now changed towards preference for C-SEMS in this clinical scenario. This of course has cost implications as C- SEMS are 15–20 times more expensive than plastic stents. The aim of this study is to determine the benefit of C-SEMS over PS placement, to answer the question which stent should be inserted at the index ERCP if a patient presents with malignant obstructive jaundice <h3>Methods</h3> A retrospective audit was performed of patients undergoing ERCP with placement of plastic or SEMS for obstructive jaundice due to malignant distal biliary strictures at the RLH between March 2007 and December 2012. Clinical history, course and outcomes from MDT documents, electronic patient records and the endoscopy database were recorded on a standardised proforma. Only PS and C-SEMS insertion at the index ERCP were included. <h3>Results</h3> Of 147 patients identified, 72 were excluded (bare metal stents or partially covered metal stents placed). This left 43 in PS group and 32 in C-SEMS group. 21 patients underwent surgical resection; 17 within PS and 4 within C-SEMS. Of these no patient with C-SEMS but 3 (18%) patients with plastic stents required re-intervention prior to surgery due to stent dysfunction. In the remaining palliative patients (PS: n = 26 and C-SEMS: n = 28), 19 with plastic stents (73%) and 3 patients with SEMS (7%) required endoscopic re-intervention due to stent dysfunction (p &lt; 0.001). Median time to re-intervention was 32 days (range 5–58) for PS and 25 days (range 25–38.5) for C-SEMS (p = 0.394). Overall, PS at the index ERCP only offered definitive stenting in only 53% (23/43) compared to 91% (29/32) by C-SEMS (p = 0.001). <h3>Conclusion</h3> Placement of a fully covered SEMS (C-SEMS) at index ERCP offered a definitive procedure in majority of patients compared to plastic stent (PS) which was just over half. Whilst C-SEMS significant more expensive than PS, this increased cost may be potentially be offset by the reduction in the need for repeat ERCP intervention and subsequent stent insertions. A full cost analysis is currently being undertaken. <h3>Disclosure of Interest</h3> None Declared
Medical Organizations and Appointments on Health Boards.
Authors: Christopher G. Parnall
Journal: JAMA (1906)

Jackson, Mich., Dec. 17, 1906. <h3>To the Editor:</h3> —Through the medium ofThe JournalI should like to secure information regarding the appointment of members to local boards of health on the recommendation of the county societies or similar medical organizations. The inefficiency and dishonesty of boards appointed through political favor is so notorious that it behooves the profession to take this matter up for serious consideration, as a means of protecting both the public and themselves. If any of the readers ofThe Journalknow of such an arrangement as mentioned above I shall be greatly indebted for information as to methods and results.
Bone Marrow Oct3/4 <sup>+</sup> Cells Differentiate Into Cardiac Myocytes via Age-Dependent Paracrine Mechanisms
Authors: Benedetta A. Pallante, Inga Duignan, Daniel Okin, Andrew Chin, Michael C. Bressan, Takashi Mikawa, Jay M. Edelberg
Journal: Circulation Research (2006)

The mechanisms that govern the capacity of the bone marrow stem cells to generate cardiac myocytes are still unknown. Herein we demonstrate that the cardiomyogenic potential of bone marrow-derived Oct3/4(+)/cKit(+/-)/CXCR4(+/-)/CD34(-)/Sca1(-) cells is governed by age-dependent paracrine/juxtacrine platelet-derived growth factor (PDGF) pathways. Specifically, bone marrow cell cultures from both 3- and 18-month-old mice formed aggregates of Oct3/4(+) cells circumscribed by PDGFRalpha(+)/Oct3/4(-)/Sca1(+) cells. In young (3-month) bone marrow cell cultures, induction of PDGF-AB preceded the induction of cardiac genes and was required for the generation of cardiomyogenesis. Indeed, in old (18-month) cultures, diminished PDGF-B induction was associated with impaired cardiomyogenic potential, despite having Oct3/4 levels similar to those in the young cells. Importantly, supplementation with PDGF-AB specifically restored the cardiac differentiation capacity of the old bone marrow cells. Together these results demonstrate that, regardless of age, the bone marrow niche contains Oct3/4 stem cells that are capable of differentiating into cardiac myocytes. Moreover, this differentiation is governed by age-dependent PDGF-AB-mediated paracrine/juxtacrine pathways that may be essential in the translation of bone marrow cell-mediated cardiomyogenesis.
The Dorsal Test for Pericardial Effusion
Authors: T. Fisher
Journal: BMJ (1897)

ABSTRACT  In December 2019, an outbreak of atypical pneumonia (Coronavirus disease 2019 - COVID-19) associated with a novel coronavirus (SARS-CoV-2) was reported in Wuhan city, Hubei province, China. The outbreak was traced to a seafood wholesale market and human to human transmission was confirmed. The rapid spread and the death toll of the new epidemic warrants immediate intervention. The intra-host genomic variability of SARS-CoV-2 plays a pivotal role in the development of effective antiviral agents and vaccines, but also in the design of accurate diagnostics.  We analyzed NGS data derived from clinical samples of three Chinese patients infected with SARS-CoV-2, in order to identify small- and large-scale intra-host variations in the viral genome. We identified tens of low- or higher-frequency single nucleotide variations (SNVs) with variable density across the viral genome, affecting 7 out of 10 protein-coding viral genes. The majority of these SNVs corresponded to missense changes. The annotation of the identified SNVs but also of all currently circulating strain variations revealed colocalization of intra-host but also strain specific SNVs with primers and probes currently used in molecular diagnostics assays. Moreover, we de-novo assembled the viral genome, in order to isolate and validate intra-host structural variations and recombination breakpoints. The bioinformatics analysis disclosed genomic rearrangements over poly-A / poly-U regions located in ORF1ab and spike (S) gene, including a potential recombination hot-spot within S gene.  Our results highlight the intra-host genomic diversity and plasticity of SARS-CoV-2, pointing out genomic regions that are prone to alterations. The isolated SNVs and genomic rearrangements, reflect the intra-patient capacity of the polymorphic quasispecies, which may arise rapidly during the outbreak, allowing immunological escape of the virus, offering resistance to anti-viral drugs and affecting the sensitivity of the molecular diagnostics assays.
The Combined Use of Ibutilide as an Active Control With Intensive Electrocardiographic Sampling and Signal Averaging as a Sensitive Method to Assess the Effects of Tadalafil on the Human QT Interval
Authors: Charles M. Beasley, Malcolm I. Mitchell, Alex A. Dmitrienko, Jeffrey T. Emmick, Wei Shen, Timothy M. Costigan, Alun W. Bedding, Michael A. Turik, Arash Bakhtyari, Margaret R. Warner, Jeremy N. Ruskin, Louis R. Cantilena, Robert A. Kloner
Journal: Journal of the American College of Cardiology (2005)
Studies on the phagocytic activity of the granulocytes in psoriasis and palmoplantar pustulosis
Authors: A. LUNDIN, L. HAKANSSON, R. HALLGREN, GERD MICHAELSSON, P. VENGE
Journal: British Journal of Dermatology (1983)

A kinetic method was used to determine the rates of phagocytosis of IgG‐coated and C3b‐IgG‐coated latex particles by neutrophil granulocytes from twenty patients with psoriasis and twenty with palmoplantar pustulosis (PPP). Patients with psoriasis showed a highly increased rate of uptake of IgG‐coated particles. An increased rate was also observed in patients with PPP. These results indicate enhanced Fc‐receptor function. In healthy controls the uptake rate of C3b‐IgG‐coated particles was at least 30% higher than that of particles coated with IgG alone. In nearly half of the patients in the psoriasis and PPP groups the uptake rate failed to increase in the normal way, indicating that C3b dysfunction is common in both psoriasis and PPP. In neither group was there any relationship between the rate of phagocytosis and the clinical severity of the disease.