Ocular Venous Occlusion and Hyperhomocysteinemia
Authors: Emile L.E. de Bruijne
Journal: Annals of Internal Medicine (1999)

Letters5 January 1999Ocular Venous Occlusion and HyperhomocysteinemiaEmile L.E. de Bruijne, MD, Gonneke H.J.C. Keulen-de Vos, MD, and Rob J.Th. Ouwendijk, MD, PhDEmile L.E. de Bruijne, MDSearch for more papers by this author, Gonneke H.J.C. Keulen-de Vos, MDSearch for more papers by this author, and Rob J.Th. Ouwendijk, MD, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-1-199901050-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Classic homocysteinuria is an inborn error of metabolism with autosomal recessive inheritance. If homocysteinuria is untreated, about 50% of patients will have thromboembolic events, and mortality is about 20% before 30 years of age (1). Studies indicate that an elevated plasma homocysteine level is an important, independent risk factor for cardiovascular disease (2, 3).Between July 1996 and January 1998, we studied 10 men and 12 women (mean age ± SD, 65.3 ± 11.5 years) in whom an ophthalmologist had diagnosed venous occlusion in the eye. Blood was drawn for measurement of serum total cholesterol, glucose, creatinine, ...References1. Mudd SH, Skovby F, Levy HL, Pettigrew KD, Wilcken B, Pyerilz RE, et al . The natural history of homocysteinuria due to cystathionine β-synthase deficiency. Am J Hum Genet. 1985;37:1-31. MedlineGoogle Scholar2. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, et al . Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med. 1991;324:1149-55. CrossrefMedlineGoogle Scholar3. Graham IM, Daly LE, Refsum HM, Robinson K, Brattström LE, Ueland PM, et al . Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA. 1997;277:1775-81. CrossrefMedlineGoogle Scholar4. Wilcken DE, Wilcken B. The natural history of vascular disease in homocystinuria and the effects of treatment. J Inherit Metab Dis. 1997;20:295-300. CrossrefMedlineGoogle Scholar5. Peterson JC, Spence JD. Vitamins and progression of atherosclerosis in hyper-homocyst(e)inaemia [Letter]. Lancet. 1998;351:263. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOcular Venous Occlusion and Hyperhomocysteinemia Didier Ducloux , Catherine Bresson-Vautrin , and Jean-Marc Chalopin Ocular Venous Occlusion and Hyperhomocysteinemia Johan R.M. Cruysberg Metrics Cited byVenous Thromboses at Unusual SitesVenous Thromboses at Unusual SitesSEQUENTIAL BILATERAL CENTRAL RETINAL VEIN OCCLUSIONS IN A CYSTIC FIBROSIS PATIENT WITH HYPERHOMOCYSTEINEMIA AND HYPERGAMMA-GLOBULINEMIAVenous Thromboses at Unusual SitesHyperhomocysteinemia in patients with diabetes mellitus with and without diabetic retinopathyHomocysteine Increases the Expression of Vascular Endothelial Growth Factor by a Mechanism Involving Endoplasmic Reticulum Stress and Transcription Factor ATF4Meta-analysis of plasma homocysteine, serum folate, serum vitamin B12, and thermolabile MTHFR genotype as risk factors for retinal vascular occlusive diseaseGenetic determinants of fasting and post-methionine hyperhomocysteinemia in patients with retinal vein occlusionCardiovascular and thrombophilic risk factors for central retinal vein occlusionHyperhomocysteinemia: a risk factor for central retinal vein occlusionFacteurs étiologiques extraoculaires des occlusions veineuses rétiniennes. Étude rétrospective de 24 patientsOcular Venous Occlusion and HyperhomocysteinemiaJohan R.M. Cruysberg, MD, PhDOcular Venous Occlusion and HyperhomocysteinemiaDidier Ducloux, MD, Catherine Bresson-Vautrin, MD, and Jean-Marc Chalopin, MD 5 January 1999Volume 130, Issue 1Page: 78KeywordsAtherosclerosisBlood plasmaCyanocobalaminFolic acidMedical risk factorsMethionineMortalityProteinsPyridoxineVitamins ePublished: 15 August 2000 Issue Published: 5 January 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...