tbuckley/cabot-search huggingface dataset:
Wearable Devices as Facilitators, Not Drivers, of Health Behavior Change
Authors: Mitesh S. Patel, David A. Asch, Kevin G. Volpp
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Further Observations on Teaching the Doctor-patient Relationship.
Authors: Seymour Pollack
Journal: Annals of Internal Medicine (1965)

s1 May 1965Further Observations on Teaching the Doctor-patient Relationship.Seymour Pollack, M.D.Seymour Pollack, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1082_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor the previous 6 years a patient interview and discussion course focusing on the doctor-patient relationship has been conducted for freshmen medical students at the University of Southern California School of Medicine. Changes in the format and content that have taken place in the past few years will be described. Instructors view this course as one that dramatically highlights the student's psychological problems, particularly those in his interpersonal relationships, which are potential sources of difficulty for future medical practice. An initial appraisal of the course reveals that both instructors and students see the primary purpose of this program as exploring... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1082-1083KeywordsForecasting Issue Published: 1 May 1965 PDF downloadLoading ...
Non-steroidal anti-inflammatory drugs and peptic ulcer perforation.
Authors: D S Collier, J A Pain
Journal: Gut (1985)

A retrospective study is reported in which the ingestion of non-steroidal anti-inflammatory drugs (NSAID) in 269 patients with perforated peptic ulceration and 269 age/sex matched controls admitted between 1973-1982 was compared. A highly significant statistical difference was found (p less than 0.001) in those aged over 65. There was no statistical difference, however, in those aged under 65. Furthermore we have shown a highly statistically significant correlation (p less than 0.0001) between the annual number of patients aged over 65 with perforated peptic ulcers taking NSAID and the annual number of prescriptions issued for these drugs in the region. No such correlation was found for patients aged under 65 years. We suggest that the elderly especially women are unduly susceptible to NSAID associated peptic ulcer perforation, and discuss factors that may account for this.
TCT- 365 Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut-to-wall Detachment Distance
Authors: Nicolas Foin, Shimpei Nakatani, Christos Bourantas, Sayan Sen, Sukhjinder S. Nijjer, Ricardo Petraco, Matteo Ghione, Yoshinobu Onuma, Darrel P. Francis, Carlo Di Mario, Justin E. Davies, Patrick W. Serruys
Journal: Journal of the American College of Cardiology (2014)
The Ties That Bind: Maternal-Infant Interactions and the Neural Circuitry of Postpartum Depression
Authors: Ellen Leibenluft, Kimberly A. Yonkers
Journal: American Journal of Psychiatry (2010)

Little is known about the pathophysiology of postpartum depression.While the same can be said for many (if not most) psychiatric illnesses, in the case of postpartum depression the need for pathophysiological studies to guide the development of novel treatments is particularly pressing because the illness affects not only the woman who experiences it, but also her newborn and other members of her family (1).But while pathophysiological studies of postpartum depression are particularly important, they are also very difficult to conduct, given the biological and logistical complexities that characterize the postpartum period.Therefore, the study by in this issue of the Journal is a welcome addition to the literature.The authors used functional magnetic resonance imaging (fMRI) to study 16 healthy women and 14 unmedicated unipolar depressed women within 12 weeks of giving birth.While being scanned, subjects completed a task that included shape and face matching blocks, with the latter including angry and sad faces.This task is designed to probe between-group differences in amygdala activity.Previous fMRI studies using similar tasks in patients with depression demonstrate abnormalities in amygdala activity and amygdala-medial prefrontal cortex connectivity in response to negatively valenced emotional faces (3).However, the precise nature of those abnormalities, and the extent to which they differ in unipolar versus bipolar depression, remains unclear.Given the previous literature, Moses-Kolko et al. focused their analysis on activity in the amygdala and the medial prefrontal cortex.Their major finding was a group-by-condition interaction in the dorsomedial prefrontal cortex (the finding was specifically in Brodmann's area 32).While both depressed and comparison mothers activated this region more in response to faces than to shapes, depressed mothers activated more in response to shapes than comparison mothers, and comparison mothers activated more in response to faces than depressed mothers.As discussed below, the dorsomedial prefrontal cortex is known to mediate important aspects of social cognition.Therefore, it is notable that depressed mothers, relative to comparison mothers, show decreased activation in this region in response to the social stimulus of a face.Moses-Kolko et al.'s finding indicates that it is important to focus research and treatment strategies not only on a mother's depression, but also on her ability to engage affectively with her infant.A hallmark of depression is increased self-focus, particularly in the form of self-referential negative thoughts; research suggests that this symptom may be mediated by the dorsomedial prefrontal cortex.For example, Johnson et al. (4) found associations between activity in the
ANOTHER SINGULAR CASE OF ALOPECIA
Authors: G. S. Morris
Journal: BMJ (1853)

situation is th6 garden of the north of England.Before the apearance of the cholera, there was a stout fight for the Public Health Act, and the obstructivres wrere beaten.Some of the medical men opposed the introduction of the act.Mr. Fairbridge, surgeon, has died at Hexham.There are thirteen deaths in that town.The cholera has visited nearly all the villages by the side of the Tyne.There have been four deaths at Howdon and Willington; four at
IVF raises risk of developmental problems in premature infants, finds study
Authors: J. Sarkar
Journal: BMJ (2013)

An Australian study has found that very premature babies born after in vitro fertilisation (IVF) treatment are more likely to have some functional disability at ages 2 and 3 years than babies who were conceived naturally.

The researchers, from a number of medical institutions in Australia, looked at neurodevelopmental outcomes in 1473 infants who were born between 1998 and 2004 at less than 29 weeks’ gestation. Fifteen per cent (217) of these babies were born after assisted conception, either IVF or hyperovulation.

The researchers used …
Targeted Modification of Atrial Electrophysiology by Homogeneous Transmural Atrial Gene Transfer
Authors: Kan Kikuchi, Amy D. McDonald, Tetsuo Sasano, J. Kevin Donahue
Journal: Circulation (2005)

Safe and effective myocardial gene transfer remains elusive. Heterogeneous ventricular gene delivery has been achieved in small mammals but generally with methods not readily transferable to the clinic. Atrium-specific gene transfer has not yet been reported. We hypothesized that homogeneous atrial gene transfer could be achieved by direct application of adenoviral vectors to the epicardial surface, use of poloxamer gel to increase virus contact time, and mild trypsinization to increase virus penetration.We "painted" recombinant adenovirus encoding the reporter gene Escherichia coli beta-galactosidase directly onto porcine atria. Investigational variables included poloxamer use, trypsin concentration, and safety. Using the painting method, we modified the atrial phenotype with an adenovirus expressing HERG-G628S, a long-QT-syndrome mutant. Our results showed that application of virus with poloxamer alone resulted in diffuse epicardial gene transfer with negligible penetration into the myocardium. Dilute trypsin concentrations allowed complete transmural gene transfer. After trypsin exposure, echocardiographic left atrial diameter did not change. Left atrial function decreased on postoperative day 3 but returned to baseline by day 7. Tissue tensile strength was affected only in the 1% trypsin group. HERG-G628S gene transfer prolonged atrial action potential duration and refractory period without affecting ventricular electrophysiology.We show complete transmural atrial gene transfer by this novel painting method. Adaptation of the method could allow application to other tissue targets. Use with functional proteins in the atria could cure or even prevent diseases such as atrial fibrillation or sinus node dysfunction.
Gangliosides and the Guillain-Barre syndrome No causal link
Authors: J C Samson, M G Fiori, F Grigoletto, M Massarotti, R Matano
Journal: BMJ (1994)

EDITOR, - Gianluca Landi and colleagues report that 25 cases of the Guillain-Barre syndrome after treatment with gangliosides were seen over four and a half years in Italy, a yearly average of 5.6 cases.1 Their conclusion that these cases represent an excess incidence is incorrect. Their data estimate a yearly exposed population of roughly 2500 000 (4.2% of the Italian population). The 5.6 cases represent a yearly incidence of 0.2/100 000. Eleven of their patients were over 60. The incidence of the Guillain-Barre syndrome is known to be higher in older age groups: an incidence of 3.2/100 000 a year has been reported in people over 60.2

We believe that it is inappropriate to compare the incidence of the Guillain-Barre syndrome in the normal population with that in patients selected for treatment with gangliosides - that is, patients with neuropathy - as the frequency of the syndrome seems to be increased in these patients. This is exemplified by surveys of referrals for generically defined neuropathy3,4: on accurate examination 11-12% of the cases were diagnosed as cases of the Guillain-Barre syndrome. The syndrome may therefore be diagnosed in over 10% of patients with neuropathy (especially elderly patients), who potentially qualify for ganglioside treatment.

The authors have not exluded the possibility that gangliosides were prescribed for initial signs of …
Malignant Neoplasms Occurring After Cardiac Transplantation
Authors: Robert P. Lanza
Journal: JAMA (1983)

Fifty-seven cardiac transplants in 53 patients have been performed; 30 survived for at least three months. Malignant neoplasms developed in three (10%) of these patients. This incidence is more than double that in recipients of donor kidneys at our institution. Kaposi's sarcoma developed in three patients in the combined groups and accounted for 30% of all malignant neoplasms. The possible reasons for these high incidences are discussed.
208. Physicochemical and Biological Characterization of Cyclodextrin-Based Polycation (CDP)/siRNA Composites Designed for Systemic Delivery
Authors: Derek W. Bartlett, Jeremy D. Heidel, Mark E. Davis
Journal: Molecular Therapy (2005)

The feasibility of systemic nucleic acid delivery hinges on the ability to simultaneously incorporate numerous properties into the overall delivery system. For example, the delivery vehicle must have the following characteristics: (i) be small enough to travel through blood capillaries and enter tissues, but not be too small such that it is excreted rapidly through the kidneys; (ii) provide stability against degradation, yet willingly release its cargo once it arrives at the proper site; and (iii) avoid nonspecific interactions (i.e., avoid opsonization by immune system components) while still providing specific targeting to a given cell or molecule. We are developing a cyclodextrin-based polycation (CDP) that achieves a favorable balance in all of these design criteria. Here, we show the physicochemical characterization of the colloidal, composite particles formed with CDP and siRNAs through dynamic light scattering (DLS), multi-angle laser light scattering (MALLS), and gel mobility shift assays to quantitate the size and composition. Upon providing steric stabilization of the particles by surface PEGylation, we determine the average number of polyethylene glycol (PEG) molecules on each particle by isothermal titration calorimetry (ITC) and the average number of targeting ligands per particle using fluorescently labeled transferrin (Tf). Biological characterization of the particles reveals that they provide nuclease resistance to nucleic acids, do not aggregate in the presence of serum, and do not cause any observable hemolysis or aggregation of erythrocytes. Complement activation by polycations is often cited as a major concern for their in vivo application. We show that, at the concentrations required for in vivo delivery of siRNA, the complement activation is negligible for the PEGylated particles. This extensive physicochemical and biological characterization of the composite particles demonstrates their suitability for in vivo delivery of siRNA and provides a baseline for rational optimization of these particles as required for specific therapeutic applications.
Acute mesenteric ischaemia: a presenting feature of coeliac disease?
Authors: R Upadhyay, R H Park, R I Russell, B J Danesh, F D Lee
Journal: BMJ (1987)

2 observations similaires: ischemie mesenterique aigue necessitant une resection importante d'intestin grele. Les suites sont difficiles, les troubles sont attribues au syndrome d'intestin court, mais plus tard une maladie coeliaque sous-jacente est diagnostiquee, pouvant avoir joue un role dans les problemes anterieurs
Abstract 3061: Somatic mutation profiling to tumor samples using OncoCarta Panel
Authors: Kazuyuki Furuta, Tokuzo Arao, Kazuyoshi Yanagihara, Masaru Sekijima, Kazuto Nishio
Journal: Cancer Research (2011)

Abstract Clinical decision-making based on tumor genetic information have emerged as a key approach for targeted-based drugs in cancer therapy. New diagnostic approach is needed to profile for pivotal genetic mutations in multiple oncogenes simultaneously. In this study, we evaluated the validity and sensitivity of high-throughput mutation profiling approach, ‘OncoCarta Panel’, in cancer marker evaluation research. It enables us to simultaneously detect 238 mutations across 19 key oncogenes including ABL1, AKT1, AKT2, BRAF, CDK, EGFR, ERBB2, FGFR1, FGFR3, FLT3, HRAS, JAK2, KIT, KRAS, MET, NRAS, PDGFRA, PIK3CA and RET. We analyzed the somatic mutations using the OncoCarta Panel on 44 cancer cell lines and 41 clinical tumor samples. The 57% (n=25) of cancer cell lines contained one or more mutations among 44 cancer cell lines; EGFR (5/44), KRAS (13/44), BRAF (4/44), PIK3CA (3/44) and NRAS (3/44) mutations in lung, colorectal, gastric, liver and pancreatic cancer cell lines. Some samples exhibited co-occurring oncogene mutations which might modify the clinical response. In addition, this analysis was also able to perform for DNA isolated from formalin-fixed, paraffin-embedded samples. The obtained data were in concordance with the data from Sanger sequencing and Scorpions-ARMS PCR methods. The mutation was detectable even when the mutated DNA represented only 10% of the total DNA, and this was approximately 2.5-fold more sensitive than Sanger Sequencing. We conclude that the OncoCarta Panel is more rapid, sensitive and cost-effective method for mutation profiling than the commonly used Sanger sequencing. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3061. doi:10.1158/1538-7445.AM2011-3061
Cluster Mystery: Epidemic and the Children of Woburn, Mass
Authors: Robert J. McCunney
Journal: JAMA (1987)

How serious a problem is hazardous waste to the health of America? According to an Office of Technology Assessment report, about 10 000 hazardous waste sites pose a serious threat to public health (March 1985). The Office of Technology Assessment, a research arm of Congress, claims that cleanup costs can amount to $1000 per house-hold. Toxic dumps where steel drums have been left have often deteriorated, resulting in leaks that can contaminate the water supply. No state is free from these dumps. Some areas of the country have drawn greater attention because of their hazardous waste problems, especially Times Beach, Love Canal, and Woburn, Mass, the main focus of<i>Cluster Mystery</i>. Attention was called to the possible role of hazardous waste in contaminating the water supply in Woburn, a suburb north of Boston, when a local minister held a town meeting to propose an approach to investigating a potential link
Louis Ptáček receives the 2015 ASCI/Stanley J. Korsmeyer Award
Authors: Sarah Jackson
Journal: Journal of Clinical Investigation (2015)

Channelopathies encompass a diverse set of diseases that are caused by mutations in genes encoding ion channel subunits or their regulators. The first recognition of a channelopathy came from Louis Ptacek (Figure 1), whose lab cloned a mutated muscle sodium channel gene found in a family with hyperkalemic periodic paralysis. His subsequent work extends far beyond channelopathies, as he has continued studying a number of inherited, familial disorders. Ptacek’s research has identified a wide range of genes that are mutated in patients with migraine, epilepsy, cardiac arrhythmias, neurodegeneration, and circadian rhythm disorders. This year, the ASCI honors Ptacek’s outstanding work using human genetics to provide fundamental insights into the molecular mechanisms that drive disease pathophysiology. The JCI recently spoke with Ptacek about his path to success as a physician-scientist.
Molecular cloning and nucleotide sequence of complementary DNAs encoding human short chain acyl-coenzyme A dehydrogenase and the study of the molecular basis of human short chain acyl-coenzyme A dehydrogenase deficiency.
Authors: E Naito, H Ozasa, Y Ikeda, K Tanaka
Journal: Journal of Clinical Investigation (1989)

Complementary DNAs encoding the precursor of human placental short chain acyl-coenzyme A (CoA) dehydrogenase (SCAD) (EC 1.3.99.2) were cloned and sequenced. The cDNA inserts in these clones were 1,852 bases in length combined, and encoded the entire 412-amino acid precursor SCAD (mol wt 44,303). This sequence included the 24-amino acid leader peptide moiety (mol wt 2,576) and 388 amino acids corresponding to the mature protein (mol wt 41,727). The comparison of SCAD and medium chain acyl-CoA dehydrogenase sequences revealed a high degree of homology, suggesting that these enzymes evolved from a common ancestral gene and belong to a gene family. We also studied mutant human SCAD in cultured skin fibroblasts from three patients with hereditary SCAD deficiency. Labeling fibroblast cultures with [35S]-methionine followed by immunoprecipitation with anti-SCAD antibody revealed that a normal size variant SCAD protein was synthesized. In all of the three SCAD-deficient cell lines, the size of variant SCAD mRNA as determined by Northern blotting using one of the normal SCAD cDNA as a probe was also normal, and no difference was observed on Southern blots in the restriction patterns of mutant genomic DNA using EcoRI, TaqI, HincII, and BamHI. These results suggest that the defects in SCAD in these cell lines are caused by a point mutation.
Epilepsia Partialis Continua
Authors: Donald A. Johnson
Journal: JAMA (1969)

A case of epilepsia partialis continua was caused by a subdural hematoma. Muscular contractions occurred primarily in the abdominal region. In this instance, the etiology of the syndrome is unique, and the primary involvement of the abdominal musculature is remarkable. Recent neurophysiological studies have shown the abdominal muscles to be separately represented in the cerebral cortex and to have a specific descending pathway in the spinal cord. The case reported here may be the clinical expression of activity in such a neural pathway.
Immunology for Students of Medicine
Authors: Kurt Stern
Journal: JAMA (1970)

During the last decade it is neither the rate of progress nor the number of significant discoveries that distinguish advances made in immunology from those in other branches of biomedical science. It is rather the speed with which new knowledge has been transferred from the laboratory bench to the bedside. And, vice versa, challenges posed by human disease have been met by successful experimentation. The third edition of this remarkable book supports such a view and, parenthetically, invalidates the alleged conflict between basic and applied research. The growth and change of immunologic concepts in the years since the previous edition is shown by the four new chapters:: the specific immune response; complement; the mechanism of immunoglobulins and disorders of immunoglobulin production; immunology of tumors. Discussion of many other topics has been thoroughly revised and supplemented by recent observations, with new tables, figures, and photomicrographs taken from literature published after 1964.
Frostbite and Chilblains in Upton Sinclair’s<i>The Jungle</i>
Authors: Tina M. Banzon, Scott A. Norton
Journal: JAMA Dermatology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal