tbuckley/cabot-search huggingface dataset:
Association of Patient Preferences for Participation in Decision Making With Length of Stay and Costs Among Hospitalized Patients
Authors: Hyo Jung Tak, Gregory W. Ruhnke, David O. Meltzer
Journal: JAMA Internal Medicine (2013)

Patient participation in medical decision making has been associated with improved patient satisfaction and health outcomes. However, there is little evidence concerning its effects on resource utilization. Patient participation in medical decision making has been hypothesized to decrease excess utilization but might be expected to increase utilization when other decision makers have incentives to reduce utilization, as under prospective payment systems for hospital care.To examine the relationship between patient preferences for participation in medical decision making and health care utilization among hospitalized patients.Survey study in an academic research setting.A survey that included questions about preferences to receive medical information and to participate in medical decision making was administered to all patients admitted to the University of Chicago Medical Center general internal medicine service between July 1, 2003, and August 31, 2011, and completed by 21,754 (69.6%) of admitted patients.The survey data were linked with administrative data, including length of stay and total hospitalization costs. We used generalized linear models to measure the association of patient preference for participation in decision making with length of stay and costs.The mean length of stay was 5.34 days, and the mean hospitalization costs were $14,576. While 96.3% of patients expressed a desire to receive information about their illnesses and treatment options, 71.1% of patients preferred to leave medical decision making to their physician. Preference to participate in decision making increased with educational level and with private health insurance. Compared with patients who had a strong desire to delegate decisions to their physician, patients who preferred to participate in decision making concerning their care had a 0.26-day (95% CI, 0.06-0.47 day) longer length of stay (P = .01) and $865 (95% CI, $155-$1575) higher total hospitalization costs (P = .02).Patient preference to participate in decision making concerning their care may be associated with increased resource utilization among hospitalized patients. Variation in patient preference to participate in medical decision making and its effects on costs and outcomes in the presence of varying physician incentives deserve further examination.
Serum tissue polypeptide antigen correlating with clinical course in a patient with mycosis fungoides: a potential disease marker?
Authors: S.C-S. Hu, G-S. Chen, C-S. Wu, C-C.E. Lan
Journal: British Journal of Dermatology (2007)

Journal Article Serum tissue polypeptide antigen correlating with clinical course in a patient with mycosis fungoides: a potential disease marker? Get access S.C‐S. Hu, S.C‐S. Hu Department of Dermatology, Kaohsiung Medical University Hospital, 100 Shih‐Chuan 1st Rd, Kaohsiung, Taiwan Search for other works by this author on: Oxford Academic Google Scholar G‐S. Chen, G‐S. Chen Department of Dermatology, Kaohsiung Medical University Hospital, 100 Shih‐Chuan 1st Rd, Kaohsiung, TaiwanDepartment of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan Search for other works by this author on: Oxford Academic Google Scholar C‐S. Wu, C‐S. Wu Faculty of Biomedical Laboratory Science, Kaohsiung Medical University, Kaohsiung, Taiwan Search for other works by this author on: Oxford Academic Google Scholar C‐C.E. Lan C‐C.E. Lan Department of Dermatology, Kaohsiung Medical University Hospital, 100 Shih‐Chuan 1st Rd, Kaohsiung, Taiwan Correspondence: Cheng‐Che E. Lan. E‐mail: ec_lan@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 157, Issue 2, 1 August 2007, Pages 423–425, https://doi.org/10.1111/j.1365-2133.2007.08043.x Published: 01 August 2007
Estimating platelet production in patients with HIV‐related thrombocytopenia using the immature platelet fraction
Authors: Brian Garibaldi, Rupal Malani, Hsin‐Chieh Yeh, Evan Lipson, Deborah Michell, Mosi Bennett, Alison Moliterno, Michael A. McDevitt, Thomas S. Kickler
Journal: American Journal of Hematology (2009)
HIGH ON-TREATMENT PLATELET REACTIVITY IS A PREDICTOR OF RESTENOSIS IN PATIENTS WITH CORONARY STENT IMPLANTATION
Authors: Hironori Ueda, Hiroya Matsumura, Sho Okamura, Kazuhiro Nitta, Mio Uchida, Takuo Sakura, Ryo Yamazato, Kazuyoshi Suenari, Yuichiro Watari, Yukihiro Fukuda, Hidekazu Hirao, Mitsunori Okamoto
Journal: Journal of the American College of Cardiology (2014)
Angiotensin II Type 1–Receptor Activating Antibodies in Renal-Allograft Rejection
Authors: Duska Dragun, Dominik N. Müller, Jan Hinrich Bräsen, Lutz Fritsche, Melina Nieminen-Kelhä, Ralf Dechend, Ulrich Kintscher, Birgit Rudolph, Johan Hoebeke, Diana Eckert, Istvan Mazak, Ralph Plehm, Constanze Schönemann, Thomas Unger, Klemens Budde, Hans-Hellmut Neumayer, Friedrich C. Luft, Gerd Wallukat
Journal: New England Journal of Medicine (2005)

Antibodies against HLA antigens cause refractory allograft rejection with vasculopathy in some, but not all, patients.We studied 33 kidney-transplant recipients who had refractory vascular rejection. Thirteen had donor-specific anti-HLA antibodies, whereas 20 did not. Malignant hypertension was present in 16 of the patients without anti-HLA antibodies, 4 of whom had seizures. The remaining 17 patients had no malignant hypertension. We hypothesized that activating antibodies targeting the angiotensin II type 1 (AT1) receptor might be involved.Activating IgG antibodies targeting the AT1 receptor were detected in serum from all 16 patients with malignant hypertension and without anti-HLA antibodies, but in no other patients. These receptor-activating antibodies are subclass IgG1 and IgG3 antibodies that bind to two different epitopes on the second extracellular loop of the AT1 receptor. Tissue factor expression was increased in renal-biopsy specimens from patients with these antibodies. In vitro stimulation of vascular cells with an AT1-receptor-activating antibody induced phosphorylation of ERK 1/2 kinase and increased the DNA binding activity of the transcription factors activator protein 1 (AP-1) and nuclear factor-kappaB. The AT1 antagonist losartan blocked agonistic AT1-receptor antibody-mediated effects, and passive antibody transfer induced vasculopathy and hypertension in a rat kidney-transplantation model.A non-HLA, AT1-receptor-mediated pathway may contribute to refractory vascular rejection, and affected patients might benefit from removal of AT1-receptor antibodies or from pharmacologic blockade of AT1 receptors.
Diabetes Control: Detection, Public Education and Community Aspects
Authors: Harry Blotner, Alexander Marble
Journal: New England Journal of Medicine (1951)

THE earlier diabetes is discovered the easier it is to control, the less likelihood there is of complications and the better is the prognosis. Among serious diseases few are more responsive than diabetes to specific medical management, which, even in the absence of cure, prolongs life, increases efficiency, protects earning power, minimizes disability and adds to the joy of living. However, today there are many diabetics, — roughly estimated at a million, — who are not under treatment because their condition is undiagnosed. The importance of finding the unrecognized diabetic may be judged from the fact that diabetes was twenty-seventh . . .
Raised plasma glutathione S-transferase values in hyperthyroidism and in hypothyroid patients receiving thyroxine replacement: evidence for hepatic damage.
Authors: G J Beckett, H A Kellett, S M Gow, A J Hussey, J D Hayes, A D Toft
Journal: BMJ (1985)

Using plasma glutathione S-transferase measurements hepatocellular integrity was assessed in groups of hyperthyroid and hypothyroid patients before and after treatment. Ten of 14 hyperthyroid patients had clearly raised plasma glutathione S-transferase values at presentation and in each patient treatment with either iodine-131 or carbimazole resulted in a significant fall in glutathione S-transferase. The eight hypothyroid patients had normal glutathione S-transferase values at presentation and all showed a significant increase in these after thyroxine replacement therapy. In three of these patients in whom standard doses of replacement therapy were associated with a raised free thyroxine (T4) concentration but normal total and free triiodothyronine (T3) values glutathione S-transferase was increased. Similar though less consistent changes were seen in the results of standard chemical tests of liver function. It is concluded that hyperthyroidism may produce subclinical liver damage in a high proportion of patients and that this resolves with effective treatment. More important, the data suggest that hypothyroid patients receiving thyroxine replacement therapy may have similar subclinical liver damage. Patients receiving thyroxine should be monitored by the measurement of free, not total hormone concentrations, and in those in whom free T4 is raised the dose of thyroxine should be reduced. It would also be expedient to include periodic biochemical assessment of liver function in patients receiving thyroxine.
Neural Tissue Engineering: Hybrid Conducting Polymer–Hydrogel Conduits for Axonal Growth and Neural Tissue Engineering (Adv. Healthcare Mater. 6/2012)
Authors: Mohammad R. Abidian, Eugene D. Daneshvar, Brent M. Egeland, Daryl R. Kipke, Paul S. Cederna, Melanie G. Urbanchek
Journal: Advanced Healthcare Materials (2012)

Conduit hydrogels have been considered for axonal regeneration in both central and peripheral nervous systems. However, a drawback of hydrogel conduits is their lack of mechanical integrity and strength under physiological conditions. On page 762, M. R. Abidian and co-workers report a novel method for preparation of mechanically reinforced agarose nerve conduits that are then made conductive by use of a thin layer of conducting polymer pol(3,4-ethylenedioxythiophene) (PEDOT). The front cover illustrates axon guidance and growth inside a partially coated PEDOT agarose hydrogel conduit.
The effect of diltiazem on coronary flow reserve in humans.
Authors: J D Rossen, I Simonetti, M L Marcus, P Braun, M D Winniford
Journal: Circulation (1989)

Calcium channel antagonists have been shown to blunt maximal coronary flow after brief coronary occlusion and during pharmacologic coronary dilation in animals. This property, if present in humans, would result in a reduction in coronary flow reserve in the absence of intrinsic abnormalities of the coronary circulation. A reduction of maximal vasodilator capacity by calcium channel antagonists could also constitute an important anti-ischemic mechanism of action of these agents. To evaluate the effect of calcium channel antagonists on coronary flow reserve in awake humans, we measured coronary flow reserve using the coronary Doppler catheter and intracoronary papaverine at baseline and after diltiazem administered by intravenous (125 or 250 micrograms/kg bolus, 5 micrograms/kg/min infusion, n = 8) or intracoronary (150-600 micrograms bolus, n = 10) routes. Intravenous diltiazem reduced heart rate from 77 +/- 18 to 72 +/- 17 beats/min (mean +/- SD, p less than 0.005) and reduced mean arterial pressure from 96 +/- 11 to 86 +/- 15 mm Hg (p less than 0.005). Intravenous diltiazem resulted in a small decrease in coronary flow reserve (peak-to-resting flow velocity ratio) from 3.9 +/- 1.2 to 3.6 +/- 1.1 (p less than 0.01). After intracoronary diltiazem, mean arterial pressure was unchanged (control 99 +/- 12 mm Hg, diltiazem 97 +/- 13 mm Hg), and heart rate was maintained constant by atrial pacing. Coronary flow reserve was unchanged at 3.8 +/- 0.9 at baseline and after intracoronary diltiazem. Thus, treatment with diltiazem does not invalidate the measurement of coronary flow reserve for diagnostic purposes. Furthermore, these results suggest that attenuation of maximal coronary dilation by diltiazem is not a mechanism responsible for its antianginal effects.
The Prediction of Type 1 Diabetes by Multiple Autoantibody Levels and Their Incorporation Into an Autoantibody Risk Score in Relatives of Type 1 Diabetic Patients
Authors: Jay M. Sosenko, Jay S. Skyler, Jerry P. Palmer, Jeffrey P. Krischer, Liping Yu, Jeffrey Mahon, Craig A. Beam, David C. Boulware, Lisa Rafkin, Desmond Schatz, George Eisenbarth
Journal: Diabetes Care (2013)

We assessed whether a risk score that incorporates levels of multiple islet autoantibodies could enhance the prediction of type 1 diabetes (T1D).
EXPERIMENTAL OBSTRUCTION OF THE JEJUNUM
Authors: Russell L. Haden, Thomas G. Orr
Journal: The Journal of Experimental Medicine (1925)

Chemical changes are reported occurring in the blood of animals with obstruction of the jejunum, in which distilled water or sodium chloride solutions were introduced directly into the lumen of the intestine below the point of obstruction. Distilled water given daily from the beginning of the obstruction, had no influence on the development or course of the toxemia. 1 and 2 per cent salt solutions prevented a toxemia in uncomplicated cases. One animal so treated lived 30 days. Distilled water, given after the onset of toxemia, did not alter the progress or outcome of the toxemia. 10 per cent sodium chloride solution, administered after the onset of toxemia, controlled it in most cases for a long period. Hydrochloric acid had no effect on the course of the toxemia.
Low plasma folate increases risk of miscarriage, says study
Authors: D. Josefson
Journal: BMJ (2002)

Pregnant women with low plasma folate concentrations have an increased risk of miscarriage, says research from the Karolinska Institute in Stockholm, Sweden, and the US National Institute of Child Health and Human Development.

Women with low plasma folate who miscarried were more likely to have been carrying afetus with a chromosomal abnormality, while miscarriages in women with adequate folate concentrations were more likely to be of fetuses with a normal …
Laparoscopic Herniorrhaphy
Authors: Henry I. Jacoby
Journal: JAMA (1996)

<h3>Objective.</h3> —To provide clinicians with a technology assessment of the safety and effectiveness of laparoscopic herniorrhaphy for the surgical repair of inguinal hernias. <h3>Participants.</h3> —A literature review and a Diagnostic and Therapeutic Technology Assessment (DATTA) survey questionnaire were mailed to 75 physicians with expertise in surgical repair of inguinal hernias. These panelists had been nominated to the DATTA panel by the appropriate specialty societies and medical schools. A total of 55 panelists (73%) responded. <h3>Evidence.</h3> —Assessment was based on the expert opinion of the panelists, as well as on published literature (available as of February 8,1996). Published studies were identified by a MEDLINE search using the terms<i>laparoscopic surgery, inguinal hernia</i>, and<i>laparoscopic herniorrhaphy</i>and by review of the references cited in these primary sources. <h3>Consensus Process.</h3> —The respondents completed a DATTA survey questionnaire; the survey results were tabulated, analyzed, and interpreted by American Medical Association staff. <h3>Conclusions.</h3> —The DATTA panelists rated the use of laparoscopic herniorrhaphy as promising for safety and investigational for effectiveness for two indications: the repair of primary inguinal hernias and the repair of bilateral inguinal hernias. The use of laparoscopic herniorrhaphy to repair recurrent inguinal hernias was rated as investigational for both safety and effectiveness by the panel. This technique was rated as promising for safety and effectiveness as a method for decreasing postoperative tenderness and time until return to full activity. (<i>JAMA</i>. 1996;275:1075-1082)
Effects of probucol on plasma cholesterol, high and low density lipoprotein cholesterol, and apolipoproteins A1 and A2 in adults with primary familial hypercholesterolemia
Authors: Margot J. Mellies, Peter S. Gartside, Lenora Glatfelter, Peter Vink, Greg Guy, Gustav Schonfeld, Charles J. Glueck
Journal: Metabolism (1980)
Case series of transpancreatic septotomy as precutting technique for difficult bile duct cannulation
Authors: D. Kapetanos, G. Kokozidis, D. Christodoulou, K. Mistakidis, K. Dimakopoulos, E. Katodritou, G. Kitis, E. Tsianos
Journal: Endoscopy (2007)

See also: Commentaire de travail de D. Kapetanos et al., pp. 802Endoscopy 2007; 39(09): 931-932DOI: 10.1055/s-0032-1308869
573 DEVELOPMENT OF A HIGHLY SENSITIVE SYSTEM FOR THE DETECTION AND QUANTIFICATION OF ALL MAJOR HBV RESISTANCE MUTATIONS BASED ON ARMS RT-PCR WITH MOLECULAR BEACON
Authors: F. Ntziora, D. Paraskevis, E. Magiorkinis, T. Karamitros, L. Poughias, A. Hatzakis
Journal: Journal of Hepatology (2009)
SENCAR mouse skin tumorigenesis model versus other strains and stocks of mice.
Authors: T J Slaga
Journal: Environmental Health Perspectives (1986)

The SENCAR mouse stock was selectively bred for eight generations for sensitivity to skin tumor induction by the two-stage tumorigenesis protocol using 7,12-dimethylbenz(a)anthracene (DMBA) as the initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as the promoter. The SENCAR mouse was derived by crossing Charles River CD-1 mice with skin-tumor-sensitive mice (STS). The SENCAR mice are much more sensitive to both DMBA tumor initiation and TPA tumor promotion than CD-1, BALB/c, and DBA/2 mice. An even greater difference in the sensitivity to two-stage skin tumorigenesis is apparent between SENCAR and C57BL/6 mice when using DMBA-TPA treatment. However, the SENCAR and C57BL/6 mice have a similar tumor response to DMBA-benzoyl peroxide treatment, suggesting that TPA is not an effective promoter in C57BL/6 mice. The DBA/2 mice respond in a similar manner to the SENCAR mice when using N-methyl-N-nitro-N-nitrosoguanidine (MNNG)-TPA treatment. The SENCAR mouse model provides a good dose-response relationship for many carcinogens used as tumor initiators and for many compounds used as tumor promoter. When compared to other stocks and strains of mice, the SENCAR mouse has one of the largest data bases for carcinogens and promoters.
Molecular Diagnosis of Circulating Cancer Cells Using MAGE Gene Assays
Authors: Masaki Mori, Koshi Mimori, Fumiaki Tanaka, Hiroaki Ueo, Keizo Sugimachi, Tsuyoshi Akiyoshi
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Reverse transcription—polymerase chain reaction (RT-PCR) of messenger RNA of a specific gene may be a powerful tool to detect small numbers of circulating cancer cells in the blood. With respect to common solid cancers, cytokeratin or carcinoembryonic antigen genes have been used as target genes for RT-PCR. However, these genes are not specific to cancer cells. Recently, a number of genes that code for tumor antigens have been isolated. Some of these genes are expressed in various tumors, but are otherwise silent in normal adult tissue, except for testes. Thus, these antigens appear to be potential targets for molecular diagnosis by RT-PCR. One of these genes that codes for tumor antigens is the<i>MAGE</i>gene, the name of which is derived from melanoma antigen.<sup>2</sup><i>MAGE</i>genes consist of 12 members and are localized on chromosome X.<sup>3</sup>We previously studied the expression of 10 of the
Air Embolism during Haemodialysis
Authors: M. K. Ward, M. Shadforth, A. V. L. Hill, D. N. S. Kerr
Journal: BMJ (1971)

Two fatal and five non-fatal episodes of air embolism occurred in the course of 14,000 haemodialyses. Air entered the circuit through the infusion bottle, the heparin syringe or line, or the blood pump insert. Emergency treatment with posture, oxygen, dextran infusion, and dexamethasone was apparently successful in reversing some of the manifestations. Prevention depends partly on better design of equipment and partly on the incorporation in the haemodialysis circuit of devices which detect air and prevent it from reaching the patient. Such monitors are not in general use in the United Kingdom and those currently available are far from infallible. We describe an alternative system incorporating a floating valve in the bubble trap.
Aberrant GM-CSF signal transduction pathway in juvenile myelomonocytic leukemia assayed by flow cytometric intracellular STAT5 phosphorylation measurement
Authors: G Gaipa, C Bugarin, D Longoni, S Cesana, C Molteni, A Faini, F Timeus, M Zecca, A Biondi
Journal: Leukemia (2008)
1248 ORAL ADMINISTRATION OF NANOPOROUS CARBONS REDUCE SEVERITY OF NON-ALCOHOLIC STEATOHEPATITIS BY MODULATING HEPATIC KUPFFER CELL FUNCTION: A NOVEL THERAPEUTIC APPROACH
Authors: J. Macnaughtan, J. Soeda, A. Mouralidarane, S. Sandeman, C. Howell, S. Kozynchenko, S. Mikhalovsky, S. Tennison, N. Davies, R. Mookerjee, J. Oben, R. Jalan
Journal: Journal of Hepatology (2012)
PREVALENCE AND PREDICTORS OF CORONARY ARTERY DISEASE IN BEHCET'S DISEASE
Authors: Jalaj Garg, Parasuram Krishnamoorthy, Chandrasekar Palaniswamy, Wilbert Aronow, Jay Doshi, Gregg Lanier, Linda Cuomo, Hasan Ahmad, Julio Panza
Journal: Journal of the American College of Cardiology (2014)
Asthma in primary schools.
Authors: J Storr, E Barrell, W Lenney
Journal: BMJ (1987)

Seven schools in the Lewes area were visited to identify which children were using inhalational treatment for asthma. The attitudes of the parents and schools were assessed, as was the children9s skill in using inhalers. Five per cent of all children were receiving inhalational treatment with bronchodilator drugs. On average they had missed seven school days in the past year. The opinions of the parents about treatment appeared to be determined by the severity of the child9s asthma. Most schools coped well with giving bronchodilators, though there was no real understanding of the nature of the disease or treatment. Most children who had received pressurised inhalers could not use them satisfactorily.
The Textbook of Spinal Surgery
Authors: Robert Goodkin
Journal: JAMA (1997)

Since the first edition in 1991 of<i>The Textbook of Spinal Surgery</i>, edited by Bridwell and DeWald, this subject has received increased attention, possibly because some neurosurgeons and orthopedic surgeons now identify themselves as "spine surgeons"; there are now a number of textbooks on spinal surgery from which to choose. Also, spinal surgery is now learned in fellowship programs or additional special courses on spinal procedures, particularly instrumentation and fusion techniques, which have become routine in the management of many spinal affections. In this second edition, Bridwell and DeWald have expanded the text from more than 1200 pages to nearly 2400 and have increased the number of chapters from 45 to 130 and the number of contributors from 60 to 182. As with many textbooks on affections of the spine, the emphasis is orthopedic, with orthopedist contributors far outnumbering neurosurgeon contributors. The book has two volumes and 13 sections: "General
Smiling reflects different emotions in men and women – ERRATUM
Authors: Simine Vazire, Laura P. Naumann, Peter J. Rentfrow, Samuel D. Gosling
Journal: Behavioral and Brain Sciences (2012)

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