tbuckley/cabot-search huggingface dataset:
Diagnostic strategy for patients with suspected pulmonary embolism: a prospective multicentre outcome study
Authors: Dominique Musset, Florence Parent, Guy Meyer, Sophie Maître, Philippe Girard, Christophe Leroyer, Marie-Pierre Revel, Marie-France Carette, Marcel Laurent, Bernard Charbonnier, François Laurent, Hervé Mal, Michel Nonent, Rémi Lancar, Philippe Grenier, Gerald Simonneau
Journal: The Lancet (2002)
IMPROVED OPERATION FOR HYPOSPADIAS INVOLVING THE GLANS AND PENILE PORTION OF THE URETHRA.
Authors: J. COPLIN STINSON
Journal: JAMA (1905)

Hypospadias is a condition due to want of fusion of the lips of the urogenital sinus which go to form the urethra and varies in degree from an unduly large meatus to a completely cleft urethra. This deformity, unlike the somewhat similar condition of epispadias, never extends into the bladder, and incontinence of urine is, therefore, not one of its complications. In hypospadias affecting the glans the inconvenience may be so slight as to be almost unnoticeable, but it increases the further back the cleft extends. There are two troubles in connection with hypospadias: In the first place the urethral opening is always unduly narrow, sometimes extremely so, and there is, therefore, a certain amount of back pressure from which serious results may follow. The second trouble is that the penis is always curved downward when the cleft in the urethra extends any distance back, and this incurvation is greater
Herpes Simplex Esophagitis
Authors: F L Urbano, M T Nguyen
Journal: New England Journal of Medicine (1999)

Figure 1. A 47-year-old woman with a history of hypertension and alcohol abuse had had fatigue, nausea, vomiting, and abdominal pain for two days. On admission, she vomited coffee-grounds material. The blood pressure, measured while she was upright, was 80/50 mm Hg. Examination revealed no fever or lesions of the mouth. The patient had epigastric tenderness, but the bowel sounds were normal and there was no rebound tenderness. The serum amylase level was 244 U per liter, the serum lipase level was 5922 calcium level was 3.1 mmol per liter, and the serum bicarbonate level was 19 mmol per liter. . . .
Thirteen Cases of Hysterectomy, with Remarks on Carbolic Acid Spray in Abdominal Surgery
Authors: T. Keith
Journal: BMJ (1885)

MEDICAL JOURNAL of December 8th, 1883, notes are given of all my cases of supravaginal hysterectomy, twenty-five in number.During the past year, other thirteen cases have been operatedon, bringing the number up to thirty-eight hysterectomies, with three deaths.Besides these, both ovaries were removed twelve times to check the growth of bleeding fibroids.These were successful operations, more or less benefit having in every case already resulted.In only one has menstruation continued.In that case, a fragment of ovarian structure was left closely adherent to the tumour, and over that part there is still pain at intervals.The tumour is, however, much smaller, and the patient's general condition is better thanbefore.In every case one menstrual period came on, generally beginning on the third day.In upwards of sixty operations of double ovariotomy that I have performed for disease, in only a single instance, to the best of my knowledge, has menstruation recurred regularly, and in that case, also, part of one adherent ovary was left behind.Thirteen Cases of Hysterectomy.
Abstract 1527: CD44v9 involving in multiple myeloma cells adhesion to bone marrow stromal cell promotes bone erosion by augmenting the activation of HGF-receptor/cMet
Authors: Chansu Lee, Kwang-Sung Ahn, JIyeon Ryu, Soyoung Park, Woo June Jung, Juwon Park, Eunkyung Bae, Sung-Soo Yoon
Journal: Cancer Research (2012)

Abstract The main aim of our study is to determine the significance of the stromal microenvironment in the malignant behavior of multiple myeloma cells. The stroma-derived growth factors/cytokines and hyaluronan act in autocrine/paracrine ways with their receptors, including receptor-tyrosine kinases and CD44 variants (CD44v), to potentiate and support multiple myeloma cell survival. In this study, we found that CD44s and CD44 variants were differentially expressed between fraction of CD138+ fraction and CD138- fraction. Expression levels of CD44v6, CD44v9, and CD44v10, respectively, correlated with bone erosion (p=0.029, p=0.013, p=0.032), suggesting that CD44 variant molecules are involved in multiple myeloma progression. Binding studies using CD44 isoform specific reagents showed that CD44v6 and CD44v9 were involved in binding to bone marrow stromal cells, but not to in vitro synthesized ECM. In 3D culture, CD44v6 and CD44v9-mediated plasma cell binding resulted in a significant induction of HGF secretion by bone marrow stromal cells. CD44v6 and CD44v9-mediated plasma cell binding significantly induces PI3K/Akt via activation the Src-kinase Lyn. In bone marrow serum of MM patients, the expression levels of IL-6, OPN, and hepatocyte growth factor (HGF), respectively, statistically correlated with bone erosion of MM patients (p=0.021, p=0.001, p=0.036). HGF derived from bone marrow stromal cells with multiple myeloma cells stimulates CD44 signaling via activation of HGF-receptor/cMet. Specific CD44 shRNA suppresses HGF-mediated CD44 signaling. Taken together, the role of CD44 variants in adhesion induced HGF- secretion may explain the previously observed correlation between CD44 variants expression and adverse prognosis in multiple myeloma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1527. doi:1538-7445.AM2012-1527
Horseshoe Kidney Simulating Acute Gastrointestinal Hemorrhage on Technetium-99m Labeled Red Blood Cell Imaging
Authors: FREDERICK L. DATZ, WILLIAM R. BILOTTA
Journal: Clinical Nuclear Medicine (1988)

A case of horseshoe kidney simulated hemorrhage in the transverse colon during Tc-99m RBC bleeding imaging is presented. A DMSA scan was useful in preventing a false-positive interpretation. A horseshoe kidney should be considered when U-shaped activity is seen in the region of the transverse colon on Tc-99m RBC bleeding scans.
Should Syphilitics Marry?
Authors: John M. Batten
Journal: JAMA (1889)

Medical gentlemen writing to the Editor ofThe Journalwill please conform to the rule requiring MS. to be written on one side of the paper, to take pains to write the names of persons and places legibly, and to send their own names as a guarantee of good faith. <h3>To the Editor:</h3> —Some questions that are not clear to my mind in the light of my present knowledge. 1. Is syphilis a curable disease? or is it possible to eradicate all the syphilitic germs from a syphilitic? 2. Is not a person once a syphilitic always a syphilitic? 3. Is the germ of tertiary syphilis the same as the germ of secondary syphilis, and also the same as that germ which causes chancre? or is their virulency modified by removal from the chancre? 4. Is it possible to inoculate a non-syphilitic by serum or secretions from a tertiary syphilitic
Toll-like receptor agonists regulate β-defensin 2 release in hair follicle
Authors: S. Selleri, F. Arnaboldi, M. Palazzo, S. Gariboldi, L. Zanobbio, E. Opizzi, Y.F. Shirai, A. Balsari, C. Rumio
Journal: British Journal of Dermatology (2007)

Skin is constantly in contact with different pathogens, which are present in the environment. The hair follicle is particularly susceptible to this microbial invasion as it offers an easy way of access for microorganisms; for this reason it is equipped with defence mechanisms to avoid frequent infections.To analyse the expression pattern of four different members of the toll-like receptor (TLR) family in murine hair follicles and to evaluate the effects of their activation by their specific microbiota-derived agonists, in terms of production of the antimicrobial peptide beta-defensin 2 (DEFB2).TLR and DEFB2 protein expression was investigated by immunohistochemistry on murine skin samples.Murine hair follicle expresses TLR2, TLR4 and TLR5; agonists of TLR2, TLR4 and TLR5 but not of TLR9 induced DEFB2 production in this compartment. The strongest DEFB2 expression was observed following TLR4 activation by lipopolysaccharide.Our data show that the hair follicle is equipped with TLR2, TLR4 and TLR5, and that these receptors are able to respond to microbial stimuli inducing the production of DEFB2 by epithelial cells. This immune response might be important in preserving the skin from microorganism infections.
Slaughter of the Innocents
Authors: Mark S. Dine
Journal: JAMA (1973)

To the Editor.—  In 1961 Dr. Adelson described the slaughter of the innocents, 1 followed a year later by the article of Kempe et al 2 defining the battered child syndrome.  Now Adelson has written an article on the battering child, 3 defining another problem. All the victims in his study died. Fortunately, the outcome need not be as disastrous, as illustrated by the following two cases from my private practice.  A 6-month-old girl was examined because of an unexplained hematoma of the right side of the head. Results of neurologic examination were normal. Skull roentgenogram demonstrated multiple fractures of the right occipital and parietal bones. There was no evidence of child abuse. In retrospect, the mother remembered that a 5-year-old mentally retarded sibling had been playing, unsupervised, with the victim in a room with a cement floor. Further injury has not occurred. Four years later the patient is normal.
National Medical Association Centennial
Authors: Charles Marwick
Journal: JAMA (1995)

A CENTURY AGO, 12 African-American physicians, barred from joining local and national medical organizations and unable to obtain hospital privileges for treating their patients, gathered to form what became the National Medical Association (NMA). This year, African-American physicians for the first time head a half dozen of the most prestigious medical organizations in the United States. For its 100th annual meeting, the NMA went back to Atlanta, Ga, where it began. On a hot Sunday morning in July, several hundred members walked the three blocks from the headquarters hotel to the First Congregational Church at the corner of Courtland Street and John W. Dobbs Drive in downtown Atlanta to celebrate their organization's founding in the church in 1895. Segregation was the law of the land at the time, reaffirmed by a Supreme Court decision,<i>Plessy vs Ferguson</i>, the following year. "Conceived in no spirit of racial exclusiveness, fostering no ethnic
Multiple Filling Defects in the Colon
Authors: John E. Madewell, Maurice M. Reeder
Journal: JAMA (1975)

<h3>Common</h3> [Diverticula] Familial polyposis Polyps, adenomatous Pseudopolyps of ulcerative colitis, granulomatous colitis, amebiasis Stool; foreign bodies; air bubbles; food particles; mucus <h3>Uncommon</h3> Amebomas Amyloidosis Carcinomas, multiple Colitis cystica profunda Cronkhite-Canada syndrome Gardner syndrome Lipomatous polyposis Lymphoid hyperplasia Lymphoma Metastases Mucoviscidosis Neurofibromatosis; ganglioneurofibromatosis Parasites, intraluminal (ascariasis, trichuriasis) Peutz-Jeghers syndrome (hamartomatous polyps) Pneumatosis cystoides intestinalis Polyposis, juvenile Schistosomiasis Turcot syndrome (Entity in brackets may be confused roentgenographically with multiple filling defects in the colon.) <h3>Diagnosis</h3> Familial polyposis of the colon. <h3>Comment</h3> A 22-year-old man was first seen with anemia and failure to gain weight. No gastrointestinal or pulmonary symptoms were present. There was a strong family history of carcinoma of the colon. Physical examination was unremarkable. An upper gastrointestinal series, bone survey, and chest roentgenograms were normal. A barium enema (Fig 1) demonstrated
24 A NOVEL MOLECULAR CLASSIFICATION OF HCV-RELATED HEPATOCELLULAR CARCINOMA (HCC) BASED ON INTEGRATIVE GENOMIC ANALYSIS
Authors: D.Y. Chiang, A. Villanueva, Y. Hoshida, J. Peix, P. Newell, B. Minguez, S. Thung, M. Sole, V. Tovar, C. Alsinet, S. Roayaie, M. Schwartz, J. Bruix, C. Battiston, V. Mazzaferro, S.L. Friedman, M. Meyerson, J.M. Llovet
Journal: Journal of Hepatology (2008)
Circardian variation of QT dispersion determined by twelve-lead holter electrocardiography in patients without coronary artery disease
Authors: Kun-Tai Lee, Wen-Ter Lai, Chin-Sheng Chu, Wen-Choi Voon, Hsueh-Wei Yen, Ye-Hsu Lu, Tsung-Hsieng Lin, Sheng-Hsiung Sheu
Journal: Journal of the American College of Cardiology (2003)
Measurement of haemolysis in patients with prosthetic heart valves
Authors: J. A. F. NAPIER, I. CAVILL, C. RICKETTS
Journal: Cardiovascular Research (1979)

Journal Article Measurement of haemolysis in patients with prosthetic heart valves Get access J. A. F. NAPIER, J. A. F. NAPIER 1 From the Department of Haematology, The Welsh National School of Medicine, Cardiff 1Address for correspondence: Dr J. A. F. Napier, Welsh Regional Blood Transfusion Centre, Rhyd Lafar, St. Fagans, Nr. Cardiff CF5 6XF. Search for other works by this author on: Oxford Academic PubMed Google Scholar I. CAVILL, I. CAVILL From the Department of Haematology, The Welsh National School of Medicine, Cardiff Search for other works by this author on: Oxford Academic PubMed Google Scholar C. RICKETTS C. RICKETTS From the Department of Haematology, The Welsh National School of Medicine, Cardiff Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 13, Issue 11, November 1979, Pages 663–665, https://doi.org/10.1093/cvr/13.11.663 Published: 01 November 1979
Partial deficiency of Thyroid transcription factor 1 produces predominantly neurological defects in humans and mice
Authors: Joachim Pohlenz, Alexandra Dumitrescu, Dorothee Zundel, Ursula Martiné, Winfried Schönberger, Eugene Koo, Roy E. Weiss, Ronald N. Cohen, Shioko Kimura, Samuel Refetoff
Journal: Journal of Clinical Investigation (2002)

Three genes, TTF1, TTF2, and PAX8, involved in thyroid gland development and migration have been identified. Yet systematic screening for defects in these genes in thyroid dysgenesis gave essentially negative results. In particular, no TTF1 gene defects were found in 76 individuals with thyroid dysgenesis even though a deletion of this gene in the mouse results in thyroid and lung agenesis and defective diencephalon. We report a 6-year-old boy with predominant dyskinesia, neonatal respiratory distress, and mild hyperthyrotropinemia. One allele of his TTF1 gene had a guanidine inserted into codon 86 producing a nonsense protein of 407, rather than 371, amino acids. The mutant TTF1 did not bind to its canonical cis-element or transactivate a reporter gene driven by the thyroglobulin promoter, a natural target of TTF1. Failure of the mutant TTF1 to interfere with binding and transactivation functions of the wild-type TTF1 suggested that the syndrome was caused by haploinsufficiency. This was confirmed in mice heterozygous for Ttf1 gene deletion, heretofore considered to be normal. Compared with wild-type littermates, Ttf1(+/-) mice had poor coordination and a significant elevation of serum thyrotropin. Therefore, haploinsufficiency of the TTF1 gene results in a predominantly neurological phenotype and secondary hyperthyrotropinemia.
Identification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma
Authors: Elena Cubedo, Andrew J. Gentles, Chuanxin Huang, Yasodha Natkunam, Shruti Bhatt, Xiaoqing Lu, Xiaoyu Jiang, Isabel Romero-Camarero, Aharon Freud, Shuchun Zhao, Carlos E. Bacchi, Jose A. Martínez-Climent, Isidro Sánchez-García, Ari Melnick, Izidore S. Lossos
Journal: Blood (2012)
Epinephrine facilitates neurogenic vasoconstriction in humans.
Authors: J S Floras, P E Aylward, R G Victor, A L Mark, F M Abboud
Journal: Journal of Clinical Investigation (1988)

Numerous studies have suggested that epinephrine may facilitate neural release of NE. There have been no studies in humans that demonstrate the functional significance of this action. To determine whether epinephrine facilitates neurogenic vasoconstriction in humans, we contrasted forearm vasoconstrictor responses to a reflex stimulus (lower body negative pressure [LBNP]) and to intraarterial NE before, during, and 30 min after infusion of epinephrine (50 ng/min) or isoproterenol (10 or 25 ng/min) into a brachial artery. These doses had no systemic effects. We reasoned that if prejunctional stimulation of beta receptors by epinephrine and isoproterenol had functional significance, the vasoconstrictor response to LBNP would be potentiated in comparison to the response to NE (postjunctional mechanism). Studies were done on 23 normal male volunteers. Forearm blood flow was measured with a strain gauge plethysmograph and intraarterial pressure was recorded. The ratio of vasoconstrictor responses to LBNP/NE was used as an index of neural release of the neurotransmitter NE. This ratio increased during infusions of both epinephrine and isoproterenol. 30 min after epinephrine the vasoconstrictor response to LBNP (n = 15) was augmented from +9.9 +/- 2.2 (SE) resistance units (RU) before epinephrine to +16.4 +/- 3.2 RU (P less than 0.05); whereas the response to NE (n = 8) tended to decrease from +8.8 +/- 3.1 RU before to +4.2 +/- 1.2 RU after epinephrine (P greater than 0.05). In contrast, 30 min after isoproterenol the vasoconstrictor responses to LBNP and NE were the same as before isoproterenol. The augmented ratio of responses to LBNP/NE after epinephrine and not after isoproterenol supports the concept that epinephrine, but not isoproterenol, is taken up by the adrenergic terminal, is released subsequently during reflex stimulation, and augments the release of the neurotransmitter NE. These experiments provide the first hemodynamic evidence in humans that epinephrine and isoproterenol facilitate neurogenic vasoconstriction. The sustained effect of epinephrine in contrast to isoproterenol suggests that the late facilitation by epinephrine is related to its neural uptake and subsequent release.
Control of Neglected Tropical Diseases
Authors: Peter J. Hotez, David H. Molyneux, Alan Fenwick, Jacob Kumaresan, Sonia Ehrlich Sachs, Jeffrey D. Sachs, Lorenzo Savioli
Journal: New England Journal of Medicine (2007)

In addition to malaria, tuberculosis, and human immunodeficiency virus infection, several other infectious diseases are associated with substantial morbidity and mortality. In particular, 13 tropical diseases infect billions of people and cause disabilities such as blindness and heart failure, especially in persons who live in impoverished conditions. This review article describes approaches to the global control of these diseases.
Outcome of Patients Hospitalized for Complications after Outpatient Liver Biopsy
Authors: Christine H. Janes
Journal: Annals of Internal Medicine (1993)

To determine the safety of outpatient liver biopsies by analyzing the outcome of patients hospitalized for complications.Retrospective review.Large clinic referral center.All patients admitted after outpatient liver biopsy at the Mayo Clinic from 1 April 1989 to 1 April 1991.During this period, 405 outpatients underwent biopsy. Of the 405 patients, 13 (3.2%) were admitted with complications after biopsy. Five patients (38%) were admitted with persistent localized pain, five (38%) with orthostatic hypotension, one (8%) with both pain and hypotension, one (8%) with peritoneal signs, and one (8%) with lightheadedness but no orthostatic changes. All complications were noted within 3 hours after the biopsy. Bleeding, potentially the most serious complication, was radiographically defined in 5 of the 13 patients (38%) admitted. Only two patients, however, required blood transfusions. No patient required invasive management such as surgery or chest tube placement. The average length of the hospital stay was 1.5 days.Complications after outpatient liver biopsy occur early and rarely require invasive management. Outpatient liver biopsy is safe when done on carefully selected patients in a setting that provides close observation for at least 3 hours after liver biopsy.
Cryotherapy for Snakebite
Authors: J. Fred Mullins
Journal: JAMA (1966)

<h3>To the Editor:—</h3> I feel compelled to respond to the recent critical commentary by Bierly and Buckley (<b>195</b>:575, 1966). As I have stated before in print, the individuals who use cryotherapy properly in the treatment of snakebite swear by it, and those who do not use it condemn it to the high heavens. I have treated over 40 snakebites with this method and think it is a wonderful adjunct to other measures. The only death which we have had related to snakebite was that of a serum-sickness reaction from the horse serum in the antivenin. This cause of death was confirmed by autopsy findings. In every instance where we have given more than two ampules of antivenin, we have had a serum-sickness reaction which in many instances was more serious than the snakebite itself. The article by Bierley and Buckley will allow a great deal of medicolegal vulnerability to
Safe management of psychiatrically disturbed patients on non-psychiatric wards in the UK
Authors: N. Moran, N. Munro, K. Lawson, A. S. David
Journal: BMJ (2014)

Autoimmune encephalitis is increasingly recognised as a cause of acute psychiatric disturbance. Affected patients usually require admission to a neurology ward for assessment and treatment, and they often display serious psychiatric symptoms and disturbed behaviour.1 2 3 4

We are worried about the safe management of these patients on non-psychiatric wards. Although “organic,” these conditions manifest in a …
Abstract ED4-1: Functional imaging: Beyond FDG
Authors: Patricia M. Price
Journal: Clinical Cancer Research (2010)

Abstract Whole body FDG has become an important part of the diagnosis and staging of cancer. Worldwide, over 90% of PET imaging is now clinical whole body FDG imaging. However, in vivo molecular imaging with PET is an emerging discipline that is of importance to the development of anti-cancer therapies. As anti-cancer strategies become more directed towards a defined molecular target, we need information that is relevant to humans about whether the molecular target is expressed, the selectivity and binding of the compound for that target, and the effects of such an interaction. PET is the most sensitive and specific technique for imaging molecular pathways in vivo in humans. PET uses positron emitting radionuclides to label molecules which can then be imaged in vivo. The inherent sensitivity and specificity of PET is the major strength of this technique, able to provide quantitative kinetic information down to sub-picomolar levels. Molecular imaging with PET can provide pharmacokinetic, pharmacodynamic and mechanistic information. Use of the technique in early clinical trials can (1) provide information on optimum biological dose and PK/PD relationships; (2) identify tumours containing specific molecular targets; and (3) provide in vivo pharmacodynamic evaluation of compounds. Molecular imaging with PET has the potential to ensure a paradigm shift in drug development, to revolutionise, streamline and accelerate drug development in oncology. Examples will presented where in vivo clinical tumour and normal tissue pharmacokinetics measured by PET have helped drug development, from use with small molecules to antisense therapy. Citation Information: Clin Cancer Res 2010;16(7 Suppl):ED4-1
Diagnosis of Contralateral Testicular Intraepithelial Neoplasia (TIN) in Patients with Testicular Germ Cell Cancer: Systematic Two-Site Biopsies Are More Sensitive Than a Single Random Biopsy
Authors: Klaus-Peter Dieckmann, Magdalena Kulejewski, Uwe Pichlmeier, Volker Loy
Journal: European Urology (2006)