Diabetes Mellitus in Man and Experimental Animals
Authors: G. F. CAHILL
Journal: Annals of Internal Medicine (1967)

Editorials1 January 1967Diabetes Mellitus in Man and Experimental AnimalsG. F. CAHILL JR., M.D.G. F. CAHILL JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-1-227 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a recent communication, scientists at the Jackson Laboratory in Bar Harbor, Me., reported a mutation (db) in an inbred strain of mice which is inherited as an autosomal-recessive trait and, when homozygous, is characterized by a syndrome resembling diabetes mellitus in man (1). Other diabetic syndromes, usually associated with obesity, have been described in mice, such as the obese-hyperglycemic gene (ob) that results, in the homozygous animal, in a syndrome with minimal hyperglycemia and marked obesity, or the yellow or agouti gene (Ay), which is inherited as a dominant trait and is lethal when homozygous.In contrast to these...References1. HUMMELDICKIECOLEMAN KPMMDL: Diabetes, a new mutation in the mouse. Science 153: 1127, 1966. CrossrefMedlineGoogle Scholar2. JONES EE: Spontaneous hyperplasia of the pancreatic islets associated with glucosuria in hybrid mice, in Structure and Metabolism of the Pancreatic Islets, edited by BROLIN, S. E., HELLMAN, B., KNUTSON, H. Pergamon Press, Oxford, 1964, p. 185. Google Scholar3. LIKESTEINKEJONESCAHILL AAJEEGF: Pancreatic studies in mice with spontaneous diabetes mellitus. Amer. J. Path. 46: 621, 1965. MedlineGoogle Scholar4. SCHMIDT-NIELSENHAINESHACKEL KHBDB: Diabetes mellitus in the sand rat induced by standard laboratory diets. Science 143: 689, 1963. CrossrefGoogle Scholar5. HACKELFROHMANMIKALLEBOWITZSCHMIDT-NIELSENKINNEY DBLEHEKTD: Effect of diet on the glucose tolerance and plasma-insulin levels of the sand rat (Psammomys obesus) with special reference to the pancreas. Diabetes 15: 105, 1966. CrossrefMedlineGoogle Scholar6. MIKILIKESOELDNERSTEINKECAHILL EAAJSJGF: Acute ketotic-type diabetic syndrome in sand rats (Psammomys obesus) with special reference to the pancreas. Metabolism 15: 149, 1966. CrossrefGoogle Scholar7. MEIERYERGANIAN HGA: Spontaneous hereditary diabetes mellitus in the Chinese hamster. I. Pathological findings. Proc. Soc. Exp. Biol. Med. 100: 810, 1959. CrossrefMedlineGoogle Scholar8. GERRITSENDULIN GCWE: Serum proteins of Chinese hamsters and response of diabetes to tolbutamide and insulin. Diabetes 15: 331, 1966. CrossrefMedlineGoogle Scholar9. GONETSTAUFFACHERPICTETRENOLD AEWRAE: Obesity and diabetes mellitus with striking congenital hyperplasia of the islets of Langerhans in Spiny mice (Acomys cahirinus). Diabetologia 1: 162, 1966. CrossrefMedlineGoogle Scholar10. PINCUSWHITE GP: On the interrelation of diabetes. III. Further analysis of family histories. Amer. J. Med. Sci. 188: 159, 1934. CrossrefGoogle Scholar11. VALLANCE-OWEN J: Synalbumin insulin antagonism. Diabetes 13: 241, 1964. MedlineGoogle Scholar12. COOKEFITZGERALDMALINSPYKE AMMGJMDA: Diabetes in children of diabetic couples. Brit. Med. J. 2: 674, 1966. CrossrefMedlineGoogle Scholar13. NEEL JV: Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Amer. J. Hum. Genet. 14: 353, 1962. MedlineGoogle Scholar14. PLATORUCKNAGELGERSHOWITZ CCDLH: Studies on the distribution of glucose-6-phosphate dehydrogenase insufficiency, thalassemia, and other genetic traits in the coastal and mountain villages of Cyprus. Amer. J. Hum. Genet. 16: 267, 1964. MedlineGoogle Scholar15. OWENSULLIVANCAHILL OEJMGF: Brain metabolism during starvation. Clin. Res. 14: 351, 1966. Google Scholar16. CAHILLHERRERAMORGANSOELDNERSTEINKELEVYREICHARDKIPNIS GFMGAPJSJPLGADM: Hormonal-fuel interrelationships during fasting. J. Clin. Invest. 45: 1751, 1966. CrossrefMedlineGoogle Scholar17. RANDLEGARLANDHALESNEWSHOLME PJPBCNEA: The glucose-fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1: 785, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: G. F. CAHILLJR., M.D.These comments are based on a meeting held by the Upjohn Co. at Brook Lodge, Augusta, Mich., devoted to diabetes in experimental animals, the proceedings of which will be published in detail in Diabetologia early in 1967. The reader is referred to this publication for further details concerning inheritance, pathophysiology, and morphology of the animals described in this editorial. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byImplications of Hyperglycaemia and Cataract in a Colony of Tuco-tucos (Ctenomys talarum) 1 January 1967Volume 66, Issue 1Page: 227-230KeywordsDiabetes mellitusHyperglycemiaObesityResearch laboratoriesScientists ePublished: 1 December 2008 Issue Published: 1 January 1967 PDF downloadLoading ...