tbuckley/cabot-search huggingface dataset:
Have we reached crisis management in outpatient clinics?
Authors: D. Sellu
Journal: BMJ (1998)

I have just finished a typical outpatient clinic for patients with general and colorectal disease. I arrived at 8 30 in the morning and did not leave till 1 30 pm—officially the clinic runs from 9 00 am to 12 30 pm—and, with my registrar, saw 46 patients, more than half of them new. In a smaller clinic, which I acquired against considerable competition from other users, we see 18 patients.

What pressures are there on my clinics? I receive on average 52 new general practitioner and internal referrals each week, a third of them marked urgent. This number is over four times more than five years ago, and continues to rise steeply. I also have hundreds of patients to follow up, including those undergoing tests, those previously treated for cancer, and those requiring outpatient treatment for conditions such as haemorrhoids and complicated inflammatory bowel disease, some in the last category indefinitely. As the genetics of cancer becomes better understood, more people present for screening. I estimate that one in 10 new patients will need to remain in the system for the following five years

I have six hours a week to do all this work, a time limit imposed by the need to cater for other consultants and by the shortage of nurses. For all new patients I take …
Maternal Allergy and Asthma and Their Association With Breastfeeding In Inner-City Mothers In a Birth Cohort Study (URECA)
Authors: Katy F. Jaffee, Cynthia Visness, George T. O'Connor, Gordon R. Bloomberg, Meyer Kattan, Robert A. Wood, Peter J. Gergen, James E. Gern
Journal: Journal of Allergy and Clinical Immunology (2014)
Risk of Guillain-Barré Syndrome Following H1N1 Influenza Vaccination in Quebec
Authors: Philippe De Wals, Geneviève Deceuninck, Eveline Toth, Nicole Boulianne, Denis Brunet, Renée-Myriam Boucher, Monique Landry, Gaston De Serres
Journal: JAMA (2012)

<h3>Context</h3>In fall 2009 in Quebec, Canada, an immunization campaign was launched against the 2009 influenza A(H1N1) pandemic strain, mostly using an AS03 adjuvant vaccine. By the end of the year, 57% of the 7.8 million residents had been vaccinated.<h3>Objective</h3>To assess the risk of Guillain-Barré syndrome (GBS) following pandemic influenza vaccine administration.<h3>Design</h3>Population-based cohort study with follow-up over the 6-month period October 2009 through March 2010. The investigation was ordered by the chief medical officer of health in accordance with the Quebec Public Health Act.<h3>Setting</h3>All acute care hospitals and neurology clinics in Quebec.<h3>Population</h3>Suspected and confirmed GBS cases reported by physicians, mostly neurologists, during active surveillance or identified in the provincial hospital summary discharge database. Medical records were reviewed and cases classified according to Brighton Collaboration definitions (categorized as level 1, 2, or 3, corresponding to criteria of decreasing certainty in diagnosis). Immunization status was verified and denominators were estimated from the provincial immunization registry (4.4 million vaccinated) and census data (total target population aged ≥6 months, 7.8 million), with a total of 3 623 046 person-years of observation.<h3>Main Outcome Measures</h3>Relative and attributable risks were calculated using a Poisson model and the self-controlled case-series method.<h3>Results</h3>Over a 6-month period, 83 confirmed GBS cases were identified, including 71 Brighton level 1 through 3 cases. Twenty-five confirmed cases had been vaccinated against 2009 influenza A(H1N1) 8 or fewer weeks before disease onset, with most (19/25) vaccinated 4 or fewer weeks before onset. In the Poisson model, the age- and sex-adjusted relative risk was 1.80 (95% CI, 1.12-2.87) for all confirmed cases during the 8-week postvaccination period and was 2.75 (95% CI, 1.63-4.62) during the 4-week postvaccination period. Using the self-controlled case-series method, relative risk estimates during the 4-week postvaccination period were 3.02 (95% CI, 1.64-5.56) for all confirmed cases (n = 42) and 2.33 (95% CI, 1.19-4.57) for Brighton level 1 through 3 cases (n = 36). The number of GBS cases attributable to vaccination was approximately 2 per 1 million doses. There was no indication of an excess risk in persons younger than 50 years.<h3>Conclusions</h3>In Quebec, the 2009 influenza A(H1N1) vaccine was associated with a small but significant risk of GBS. It is likely that the benefits of immunization outweigh the risks.
Abstract 3214: Identification of a new marker of hepatocellular carcinoma with HBV in female
Authors: Wu Chen-Shiou, Yen Chia-Jui, Wu Chung-Yi, Yu Yung-Luen
Journal: Cancer Research (2011)

Abstract Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Early prognostic markers are needed to allow effective treatments and prevent HCC from developing. Serum alpha-fetoprotein, the currently used clinical marker, is elevated in only approximately 60% of HCC patients; therefore, the identification of additional markers is expected to have significant public health impact. The objective of our study was to discover and validate serum glycoprotein biomarkers in HCC using glycan microarray. We used glycan microarray for quantitative comparison of 188 in serum samples (155 HCC cases, and 33 normal). To explored the diagnostic possibilities of antibody changes as a marker for HCC. In addition, we compared the accuracy of using this serum patterns with the conventional AFP biomarkers for HCC patients. we have shown that the new biomarker with glycan microarray can be useful in the screening of serum biomarkers for HCC. The serum concentration of anti-disialogangliosides in HCC patients was significantly higher than in normal. Besides, in female the anti-gangliosides antibody in HCC patients was significantly higher than in normal. The marker candidates have good prediction sensitivity than AFP in this population. The glycan microarray thus provides a new platform for use to monitor the immune response to carbohydrate epitopes during the course of cancer progression. Additional study of its utility for diagnosis and follow-up is recommended. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3214. doi:10.1158/1538-7445.AM2011-3214
Resolution of Left Bundle Branch Block–Induced Cardiomyopathy by Cardiac Resynchronization Therapy
Authors: Caroline Vaillant, Raphaël P. Martins, Erwan Donal, Christophe Leclercq, Christophe Thébault, Nathalie Behar, Philippe Mabo, Jean-Claude Daubert
Journal: Journal of the American College of Cardiology (2013)
Taxonomic map of the schizophrenias, with special reference to puerperal psychosis.
Authors: P Hays
Journal: BMJ (1978)

Data collected by a single observer on 147 schizophrenic patients were subjected to clustering analysis. The results produced the hypothesis that schizophrenic illnesses directly after childbirth are a separate disease entity. This hypothesis was not disproved by experimental testing. Several disease entities may be included in the term schizophrenia. If this is so, the methods used in generating and testing the hypothesis that puerperal schizophrenia is a separate disease may provide a systematic method of classifying the various illnesses.
Auditory cortical plasticity: a comparison with other sensory systems
Authors: Josef P. Rauschecker
Journal: Trends in Neurosciences (1999)

The auditory cortex has a crucial role in higher cognitive functions, including the perception of speech, music and auditory space. Cortical plasticity, as in other sensory systems, is used in the fine tuning of the auditory system for these higher functions. Auditory cortical plasticity can also be demonstrated after lesions of the cochlea and it appears to participate in generating tinnitus. Early musical training leads to an expansion in the representation of complex harmonic sounds in the auditory cortex. Similarly, the early phonetic environment has a strong influence on speech development and, presumably, on the cortical organization of speech. In auditory spatial perception, the spectral cues generated by the head and outer ears vary between individuals and have to be calibrated by learning, which most probably takes place at the cortical level. The neural mechanisms of plasticity are likely to be the same across all cortical regions. It should be useful, therefore, to relate some of the findings and hypotheses about auditory cortical plasticity to previous studies of other sensory systems.
Criteria of Cure
Authors: D.J. Salfield
Journal: Psychotherapy and Psychosomatics (1956)

Research Articles| February 10 2010 Criteria of Cure: With Special Regard to Child Psychiatry Subject Area: Psychiatry and Psychology D.J. Salfield D.J. Salfield West Hallam nr. Derby Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1956) 4 (2): 107–118. https://doi.org/10.1159/000285229 Article history Published Online: February 10 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation D.J. Salfield; Criteria of Cure: With Special Regard to Child Psychiatry. Acta Psychotherapeutica et Psychosomatica 1 February 1956; 4 (2): 107–118. https://doi.org/10.1159/000285229 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1956Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Innovations in Military Corrections
Authors: DAVID B. ROBBINS
Journal: American Journal of Psychiatry (1967)

The 3320 USAF Retraining Group, an open correctional and rehabilitative facility for Air Force prisoners initiated 14 years ago, represents a marked innovation in military corrections. Short-term intensive treatment in this facility has produced a rate of return to duty averaging 51 percent, and short-term success rates for those returned to duty average 82 percent. The results of the Retraining Group program compare favorably with those of other civilian and military facilities.
MEDICAL THERAPY VERSUS IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR IN PREVENTING SUDDEN CARDIAC DEATH (SCD) IN PATIENTS WITH SYSTOLIC LEFT VENTRICULAR DYSFUNCTION &amp;amp; HEART FAILURE: A META-ANALYSIS OF &amp;gt;40,000 PATIENTS
Authors: Kah Yong Peck, Yuan Lim, Ingrid Hopper, Henry Krum
Journal: Journal of the American College of Cardiology (2012)
Margaret McCartney: Dementiagate--how politicised pay diverts GPs from working for patients
Authors: M. McCartney
Journal: BMJ (2014)

I’m wondering if this is Dementiagate—a defining moment when the UK public discovers the ugly truth about how most GPs are paid. The news from NHS England, that GPs were to receive £55 (€70; $90) for each new diagnosis of dementia, has been met with widespread condemnation and disgust.1

NHS England wants GPs to identify potential dementia patients through screening in those supposedly at risk, including people over 60 who smoke, drink too much, or are obese.2 But this is hugely problematic because such screening has not been shown to be accurate, effective, or useful.3

Who do doctors work for? For patients? How many things do we do …
India moves closer to regulating prices of patented drugs
Authors: M. Kay
Journal: BMJ (2014)

The Indian government has come a step closer to making drugs more affordable and more widely available by establishing a committee to regulate the price of patented drugs.

The new committee is to meet early next month to discuss ways to reduce prices of patented drugs. The committee, comprising representatives of the Ministry of Commerce and Industry, Ministry of Health and Family Welfare, National Pharmaceutical Pricing Authority, and Department of Pharmaceuticals, was set up …
Polymyalgia Rheumatica in Blacks
Authors: Ronald L. Kaufman
Journal: JAMA (1978)

To the Editor.—  Polymyalgia rheumatica (PMR) has been reported to have a predilection for whites. 1 It was also stated, There are no known occurrences in blacks, Orientals or American Indians. 2 Two reports have since appeared describing the condition in a black woman 3 and in an American Indian. 4 More recently, Sanford and Berney 5 described five cases of PMR appearing in blacks. The occurrence of PMR and biopsyproved temporal arteritis in blacks is even less common. To our knowledge, six cases have been reported in the literature. 3,5   Over a six-year period in a large urban hospital where a large proportion of the patients are blacks, we have treated three black patients with PMR associated with temporal arteritis. The clinical and laboratory features (Table), including the response to corticosteroid therapy, are similar to those reported in white subjects. 1 We concur with others that this disorder can
Effects of ionizing radiations on mammalian oogenesis: a model for chemical effects
Authors: T. G. Baker
Journal: Environmental Health Perspectives (1978)

A synopsis of the available data on the radiosensitivity of female germ cells is provided, the reader being referred to recent comprehensive reviews for detailed information. The effects of ionizing radiations are considered in terms of age; germ cell stage and follicular development; type, quality, and physical factors of the exposure; and criterion chosen to assess the effect (cell killing, reproductive capacity, genetic effects, etc.). A number of conclusions are drawn which might have a bearing on studies in which the effects of chemicals and drugs on mammalian species are assessed.
Primary Care Applicants — They Get No Respect
Authors: Robert G. Petersdorf
Journal: New England Journal of Medicine (1992)

In the late 1960s it was conventional wisdom that physicians were in short supply and unevenly distributed according to geography and specialty.1 The shortage, if it ever really existed, was rapidly corrected, but geographic maldistribution — the relative dearth of doctors in rural areas and inner cities —persisted, and as Colwill articulates in this issue of the Journal , 2 specialty maldistribution, exemplified by an excessive number of specialists and a corresponding paucity of generalists, is getting worse. I agree with Colwill that the shortage of general physicians is not in the best interest of the American health care system and must . . .
Effects of Barium Chloride on Resting and Action Potentials of Ventricular Fibers of the Frog
Authors: MORRIS KLEINFELD, EDWARD STEIN, STANLEY MEYERS
Journal: Circulation Research (1954)

By means of an intracellular capillary electrode the effects of barium chloride on the resting and action potentials of ventricular fibers of the frog were recorded in hearts with circulation intact and hearts isolated and perfused. The changes were essentially similar in both preparations. The major change observed was a statistically significant (p &lt;0.01) increase in duration of the action potential. Changes were also observed in the magnitude of the resting and action potential, in the rate of depolarization, and in rhythm, but these did not occur invariably. By a series of exclusion experiments it was demonstrated that barium has a direct effect on the ventricular fibers of the frog's heart.
WHAT ARE THE SYMPTOMS OF NEPHRITIS?.
Authors: ROBERT T. EDES
Journal: JAMA (1898)

This question was asked in an editorial of theJournal of the American Medical Associationof July 23, 1898, the writer in his comments seeming to intimate that the subject has been complicated rather than simplified by some of the more modern observations, and that it is surrounded by needless mystery. It is true that the diagnosis is not quite so simple as in the days when "albuminuria" covered almost the whole ground of renal pathology, while prognosis was brief and gloomy, and the clinical history prolix only, because of the great variety and severity of the symptoms which might precede the fatal termination. That, however, was longer ago than the "few years" claimed by the editor. Forty years ago it was known that albumin was to be found in the urine in many cases which were not to be considered Bright's disease, and the number of conditions in which
PROGRESS IN THE ROENTGENOLOGIC DIAGNOSIS OF DIAPHRAGMATIC HERNIA
Authors: ALEXANDER B. MOORE
Journal: JAMA (1930)

A vast and growing literature on diaphragmatic hernia, larger than the incidence of the condition would seem to warrant, attests a keen interest in this condition. Once rated as extremely rare, it is now considered more often among diagnostic alternatives because of the publicity it has received and the increasing frequency with which these hernias are being discovered. For example, as late as 1924 it was estimated that in all not more than 1,200 cases had been recorded, but these consisted chiefly of gross and easily demonstrable hernias, and since that time, besides numerous single case reports, several extensive series comprising less obvious cases have been added. When this estimate was made, only twenty cases had been listed at the Mayo Clinic, but during the last six years ninety additional cases have been observed in this clinic alone. It is evident, therefore, that diaphragmatic hernia is not merely a pathologic
Quantitative Changes In T-Cell Populations After Left Ventricular Assist Device Implantation : Relationship to T-Cell Apoptosis and Soluble CD95
Authors: H.-J. Ankersmit, N. M. Edwards, M. Schuster, R. John, A. Kocher, E. A. Rose, M. Oz, S. Itescu
Journal: Circulation (1999)

Left ventricular assist devices (LVADs) are currently being evaluated as permanent therapy for end-stage heart failure. Because life-threatening infections limit successful long-term device implantation, we investigated the relationship between quantitative T-cell defects in LVAD recipients and CD95-mediated T-cell apoptosis.Immunological studies were performed in NYHA class IV patients awaiting cardiac transplantation who received either a TCI Heartmate left ventricular assist device (LVAD) or medical management. Fluorochrome-labeled Mabs were used in T-cell phenotypic analyses. T-cell apoptosis was measured by annexin V binding of T cells cultured in medium for 24 hours. Circulating serum levels of soluble CD95 were measured by ELISA. LVAD recipients had a relative lymphopenia and reduction in CD4 T-cell levels compared with NYHA class IV heart failure controls. These observations were confirmed in a longitudinal study in LVAD recipients, which showed that device implantation was accompanied by progressive and sustained reductions in circulating CD4 T-cell levels. These abnormalities in LVAD recipients were accompanied by increased levels of circulating soluble CD95 and by excessive CD4 and CD8 T-cell apoptosis. Susceptibility to induction of apoptosis was >2-fold greater for CD4 T cells than for CD8 T cells.These results suggest that the reduction in CD4 T-cell levels accompanying LVAD implantation is a consequence of an augmented pathway of CD95-mediated apoptosis. The clinical consequences of these abnormalities may include increased prevalence of systemic infections.
The challenge of doing less
Authors: O. Dyer
Journal: BMJ (2013)

<h3>Abstract</h3> Neonatal brain injury leading to cerebral palsy (CP) is the most common cause of childhood dystonia, a painful and functionally debilitating movement disorder. Rare monogenic etiologies of dystonia have been associated with striatal cholinergic interneuron (ChI) pathology. However it is unclear whether striatal ChI pathology is also associated with dystonia following neonatal brain injury. We used unbiased stereology to estimate striatal ChI and parvalbumin-positive GABAergic interneuron (PVI) numbers in a rodent model of neonatal brain injury that demonstrates electrophysiological markers of dystonia and spasticity. Striatal ChI numbers are increased following neonatal brain injury while PVI numbers are unchanged. These numbers do not correlate with electrophysiologic measures of dystonia severity. This suggests that striatal ChI pathology, though present, may not be the primary pathophysiologic contributor to dystonia following neonatal brain injury. Increased striatal ChI numbers could instead represent a passenger or protective phenomenon in the setting of dystonic CP.