tbuckley/cabot-search huggingface dataset:
Doctors facing complaints have severe depression and suicidal thoughts, study finds
Authors: Z. Kmietowicz
Journal: BMJ (2015)

Doctors with a current or recent complaint against them are more likely to report severe depression or anxiety and to harbour suicidal thoughts than those with no complaints, a study has shown. It also found that most doctors—whether they have a complaint against them or not—are changing the way they practise medicine by taking on defensive behaviours because of the complaints process.

The study, reported in the online journal BMJ Open ,1 found that doctors who were referred to the professional regulator, the General Medical Council (GMC), seemed to be the most at risk of mental ill health.

Altogether, 7926 doctors completed an anonymised online survey sent to more than 95 000 BMA members in 2012, giving a response rate of 8.3%. The survey included questions about doctors’ personal history of complaints, the effect of going through a complaints procedure, and medical history, as well as validated tests …
Cognitive penetration: Would we know it if we saw it?
Authors: Gillian Rhodes, Michael L. Kalish
Journal: Behavioral and Brain Sciences (1999)

How can the impenetrability hypothesis be empirically tested? We comment on the role of signal detection measures, suggesting that context effects on discriminations for which post-perceptual cues are irrelevant, or on neural activity associated with early vision, would challenge impenetrability. We also note the great computational power of the proposed pre-perceptual attention processes and consider the implications for testability of the theory.
Comparative Study of NPH Human Insulin (recombinant DNA) and Pork Insulin in Diabetic Subjects: Preliminary Report
Authors: J Mirouze, L Monnier, J L Richard, A Gancel, K B Soua
Journal: Diabetes Care (1982)

Continuous blood glucose monitoring in six insulin-dependent diabetic patients shows that the biologic action of NPH human insulin (recombinant DNA) and pork insulin is similar. Nevertheless, the activity of NPH human insulin seems faster and more pronounced since minimal glycemia is lower and more rapidly reached after human insulin. The speed of glycemic increase is slightly lower and the decrease is faster with NPH human insulin; thus the area under the NPH human insulin-induced glycemic curve is less wide, but differences are not significant. Our data favor a faster and more potent effect of NPH human insulin.
Mechanism of action of angiotensin II and bradykinin on prostaglandin synthesis and vascular tone in the isolated rat kidney. Effect of Ca++ antagonists and calmodulin inhibitors.
Authors: C L Cooper, J E Shaffer, K U Malik
Journal: Circulation Research (1985)

We have studied the effect of angiotensin II and bradykinin on prostaglandin output and vascular tone during extracellular calcium depletion and administration of calcium antagonists and calmodulin inhibitors to elucidate the mechanism of action in the isolated rat kidney perfused with Tyrode's solution. Administration of angiotensin II (0.028-0.28 nmol) or bradykinin (0.28-2.8 nmol) enhanced the output of prostaglandin E2 and 6-keto-prostaglandin F1 alpha in a dose-dependent manner. Angiotensin II, but not bradykinin, produced renal vasoconstriction. Omission of calcium from the medium or infusion of calcium entry blockers, diltiazem (60 microM), or nimodipine (47 microM), failed to alter prostaglandin output elicited by angiotensin II or bradykinin; however, the effect of angiotensin II to produce renal vasoconstriction was inhibited. If calcium was omitted from the medium, the intracellular calcium antagonists, 8-(diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride (23 microM), dantrolene sodium (31 microM), or ryanodine (2 microM), attenuated prostaglandin output caused by angiotensin II but not bradykinin. Calmodulin inhibitors, trifluoperazine (2 microM), napthalene sulfonamide hydrochloride (2 microM), or calmidazolium (2 microM), diminished prostaglandin output elicited by angiotensin II, but not that caused by bradykinin. Trifluoperazine, but not naphthalene sulfonamide or calmidazolium, attenuated the renal vasoconstrictor effect of angiotensin II. Prostaglandin output induced by angiotensin II and bradykinin were inhibited by mepacrine and indomethacin, whereas, the prostaglandin output caused by exogenous arachidonic acid (33 nmol) was abolished by indomethacin but was unaltered by mepacrine, calcium antagonists, and calmodulin inhibitors. From these data, we conclude that angiotensin II produces renal vasoconstriction by a mechanism dependent on extracellular calcium but not calmodulin, whereas angiotensin II-induced prostaglandin output depends on intracellular calcium and calmodulin. In contrast, bradykinin appears to stimulate prostaglandin synthesis by a calcium/calmodulin-independent mechanism.
Geometry as a Factor for Tissue Growth: Towards Shape Optimization of Tissue Engineering Scaffolds
Authors: Cécile M. Bidan, Krishna P. Kommareddy, Monika Rumpler, Philip Kollmannsberger, Peter Fratzl, John W. C. Dunlop
Journal: Advanced Healthcare Materials (2012)

Abstract Scaffolds for tissue engineering are usually designed to support cell viability with large adhesion surfaces and high permeability to nutrients and oxygen. Recent experiments support the idea that, in addition to surface roughness, elasticity and chemistry, the macroscopic geometry of the substrate also contributes to control the kinetics of tissue deposition. In this study, a previously proposed model for the behavior of osteoblasts on curved surfaces is used to predict the growth of bone matrix tissue in pores of different shapes. These predictions are compared to in vitro experiments with MC3T3‐E1 pre‐osteoblast cells cultivated in two‐millimeter thick hydroxyapatite plates containing prismatic pores with square‐ or cross‐shaped sections. The amount and shape of the tissue formed in the pores measured by phase contrast microscopy confirms the predictions of the model. In cross‐shaped pores, the initial overall tissue deposition is twice as fast as in square‐shaped pores. These results suggest that the optimization of pore shapes may improve the speed of ingrowth of bone tissue into porous scaffolds.
Statistical Assessment of Hyperpepsinogenemia Data
Authors: ANTONY R. UNWIN
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 August 1980Statistical Assessment of Hyperpepsinogenemia DataANTONY R. UNWIN, M.D.ANTONY R. UNWIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-2-377_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I was asked as a statistician to look at the paper by Rotter and colleagues (1) in your September 1979 issue. The medical side of the article was interesting, but I have had some doubts about the handling of data and presentation of results. In Table 1 (p. 374) the definite hyperpepsinogenemic group includes 93 affected patients (that is, those with a duodenal ulcer or an elevated pepsinogen level, or both). In Table 2 (p. 375) subset 2 "is equivalent to the entire definite hyperpepsinogenemic group" but only includes 83 affected patients. What is the reason for...Reference1. ROTTERPETERSENSAMLOFF JGI. Genetic heterogeneity of hyperpepsinogenemic I and normopepsinogenemic I duodenal ulcer disease. Ann Intern Med. 1979;91:372-7. LinkGoogle Scholar1. ROTTERPETERSENSAMLOFF JGI. Genetic herogeneity of hyperpepsinogenemic I and normopepsinogenemic I duodenal ulcer disease. Ann Intern Med. 1979;91:372-7. LinkGoogle Scholar2. HODGEROTTERLANGE SJK. A three-allele model for heterogeneity of juvenile onset insulin-dependent diabetes. Ann Hum Genet. 1980;43:399-412. CrossrefMedlineGoogle Scholar3. ROTTERRIMOINSAMLOFF JDI. Genetic heterogeneity in peptic ulcer. Lancet. 1979;1:1088-9. CrossrefMedlineGoogle Scholar4. FEINSTEIN A. Clinical Biostatistics. St. Louis: C. V. Mosby; 1977. CrossrefGoogle Scholar5. ROTTERSONESSAMLOFF JJI. Duodenal-ulcer disease associated with elevated serum pepsinogen I: an inherited autosomal dominant disorder. N Engl J Med. 1979;300:63-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Dublin Dublin Ireland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1980Volume 93, Issue 2Page: 377-378KeywordsDuodenal ulcersStatistical data Issue Published: 1 August 1980 PDF DownloadLoading ...
Comparison of Plasma Glucose and Plasma Free Insulin During CSII and Intensified Conventional Insulin Therapy
Authors: M Buysschaert, E Marchand, J M Ketelslegers, A E Lambert
Journal: Diabetes Care (1983)

The plasma glucose and plasma free insulin profiles of six totally insulin-dependent diabetic patients were compared during periods of 4 days in hospital under a conventional insulin therapy (ICIT) comprising 4 daily injections of regular insulin and under continuous subcutaneous insulin infusion (CSII). Two profiles of prandial insulin administration with CSII were compared: a rectangular (R) and an exponential wave (E) in which 50% of the dose was given rapidly followed by an exponential decrease. In both cases, the basal infusion rate was increased by 30–50% between 5 a.m. and 8 a.m. Mean circadian blood glucose was equally good with ICIT: R and E: 7.0 ± 0.9, 7.3 ± 1.0, and 7.1 ± 1.0 mmol/L, respectively. In five patients, fasting plasma glucose was higher with ICIT than with R and E (12.7 ± 1.8 versus 6.9 ± 1.0 and 6.8 ± 0.8 mmol/L, respectively; t test: P &amp;lt; 0.05; Wilcoxon: P = 0.06). Mean plasma free insulin level was significantly higher (t test: P &amp;lt; 0.005; Wilcoxon: P &amp;lt; 0.05) with ICIT (0.46 ± 0.04 nmol/L) than with R (0.37 ± 0.04 nmol/L) or E (0.36 ± 0.05 nmol/L), although the daily doses were similar. In conclusion, CSII leads to a better glycemic control than ICIT, since it appears to prevent the morning rise of blood glucose.
Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects
Authors: Sven Haufe, Stefan Engeli, Petra Kast, Jana Böhnke, Wolfgang Utz, Verena Haas, Mario Hermsdorf, Anja Mähler, Susanne Wiesner, Andreas L. Birkenfeld, Henrike Sell, Christoph Otto, Heidrun Mehling, Friedrich C. Luft, Juergen Eckel, Jeanette Schulz-Menger, Michael Boschmann, Jens Jordan
Journal: Hepatology (2011)

Abstract Obesity-related hepatic steatosis is a major risk factor for metabolic and cardiovascular disease. Fat reduced hypocaloric diets are able to relieve the liver from ectopically stored lipids. We hypothesized that the widely used low carbohydrate hypocaloric diets are similarly effective in this regard. A total of 170 overweight and obese, otherwise healthy subjects were randomized to either reduced carbohydrate (n = 84) or reduced fat (n = 86), total energy restricted diet (−30% of energy intake before diet) for 6 months. Body composition was estimated by bioimpedance analyses and abdominal fat distribution by magnetic resonance tomography. Subjects were also submitted to fat spectroscopy of liver and oral glucose tolerance testing. In all, 102 subjects completed the diet intervention with measurements of intrahepatic lipid content. Both hypocaloric diets decreased body weight, total body fat, visceral fat, and intrahepatic lipid content. Subjects with high baseline intrahepatic lipids (&gt;5.56%) lost ≈7-fold more intrahepatic lipids compared with those with low baseline values (&lt;5.56%) irrespective of diet composition. In contrast, changes in visceral fat mass and insulin sensitivity were similar between subgroups, with low and high baseline intrahepatic lipids. Conclusion: A prolonged hypocaloric diet low in carbohydrates and high in fat has the same beneficial effects on intrahepatic lipid accumulation as the traditional low-fat hypocaloric diet. The decrease in intrahepatic lipids appears to be independent of visceral fat loss and is not tightly coupled with changes in whole body insulin sensitivity during 6 months of an energy restricted diet. (HEPATOLOGY 2011)
BEYTHRASMA IN A HOSPITAL FOR THE MENTALLY SUBNORMAL
Authors: DOROTHY A. SOMERVILLE, R. H. SEVILLE, R. C. CUNNINGHAM, W. C. NOBLE, J. A. SAVIN
Journal: British Journal of Dermatology (1970)

Journal Article BEYTHRASMA IN A HOSPITAL FOR THE MENTALLY SUBNORMAL Get access DOROTHY A. SOMERVILLE, DOROTHY A. SOMERVILLE St John's Hospital for Diseases of the Skin, London, W.C.2, and Department of Dermatology, Beaumont Hospital and Royal Albert Hospital, Lancaster Search for other works by this author on: Oxford Academic Google Scholar R. H. SEVILLE, R. H. SEVILLE St John's Hospital for Diseases of the Skin, London, W.C.2, and Department of Dermatology, Beaumont Hospital and Royal Albert Hospital, Lancaster Search for other works by this author on: Oxford Academic Google Scholar R. C. CUNNINGHAM, R. C. CUNNINGHAM St John's Hospital for Diseases of the Skin, London, W.C.2, and Department of Dermatology, Beaumont Hospital and Royal Albert Hospital, Lancaster Search for other works by this author on: Oxford Academic Google Scholar W. C. NOBLE, W. C. NOBLE St John's Hospital for Diseases of the Skin, London, W.C.2, and Department of Dermatology, Beaumont Hospital and Royal Albert Hospital, Lancaster Search for other works by this author on: Oxford Academic Google Scholar J. A. SAVIN J. A. SAVIN St John's Hospital for Diseases of the Skin, London, W.C.2, and Department of Dermatology, Beaumont Hospital and Royal Albert Hospital, Lancaster Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 82, Issue 4, 1 April 1970, Pages 355–360, https://doi.org/10.1111/j.1365-2133.1970.tb06832.x Published: 01 April 1970 Article history Accepted: 04 September 1969 Published: 01 April 1970
Re: Mr Cohen and the Headache
Authors: Paul Cutler
Journal: JAMA (1985)

<h3>To the Editor.—</h3> I enjoyed the anecdote about "Mr Cohen and the Headache"<sup>1</sup>and managed to grasp the valid points that were made by Susan Adelman, MD. But I believe she has told us even more than she intended. Wittily she has reminded us that treatment may legitimately begin before a diagnosis is made. Unwittingly, I believe, Dr Adelman has told us much about her diagnostic workup. I take issue with much that was said and done. I wonder if Dr Adelman's physical examination detected that the vision was not lost in the left eye, but in half the visual field of each eye.
Molecular detection of minimal residual disease in adult and childhood acute lymphoblastic leukaemia reveals differences in treatment response
Authors: L Foroni, LA Coyle, M Papaioannou, JC Yaxley, MF Cole Sinclair, JS Chim, P Cannell, LM Secker-Walker, AB Mehta, HG Prentice, AV Hoffbrand
Journal: Leukemia (1997)
Doctors vote to suspend cooperation in NHS Wide Network "Core values" initiative is welcomed Doctors criticise compulsory privatisation in health care Maintaining Medical Excellence: doctors' performance BMA will separate science and education Concentration of services threaten smaller hospitals GPs reach agreement on deprivation payments Regularising immigration arrangements In vitro diagnostic devices may be controlled
Authors: L. Beecham
Journal: BMJ (1995)

# Doctors vote to suspend cooperation in NHS Wide Network {#article-title-2}

The BMA is so concerned that identifiable patient data will not be effectively protected in the NHS Wide Network that its council has voted overwhelmingly to suspend its cooperation in the implementation of the project; the proposed implementation date is 1 April 1996. It also resolved, at its meeting last week, to commission and prepare a security policy with standards which will enable identifiable information to be sent across the network; this should aim for high standards of data security on potentially insecure networks.

The BMA believes that there should be a statutory code of practice for those using the system and not simply a code of guidance as the Department of Health has suggested and that the system must be as secure as possible by introducing safeguards such as encryption. The association has drafted a bill on the use and disclosure of personal health information, which it hopes will be considered in the House of Lords. The General Medical Council and the medical royal colleges agree with the BMA that an appropriately drafted statute is the key to protecting patients and essential functions such as research. The department believes that civil law will be sufficient to deal with any breaches of confidentiality.

In a letter to Dr Graham Winyard, medical director of the NHS Executive, the secretary of the BMA pointed out his concern that the executive would issue a security guide alone and that the link in compartmentalising information was to be the responsibility of user organisations. All the evidence, Dr Mac Armstrong said, was that the greatest threat of abuse came from inappropriate access within organisations—there will be 180000 users in the NHS network—so it was essential that the integrity of all personal health information was adequately protected. He believed that there should be security policies in …
STEMI-RVD SCALE: THE NEW TOOL TO RECOGNIZE RIGHT VENTRICULAR DYSFUNCTION IN PATIENTS WITH FIRST STEMI
Authors: Anna Szymanska, Wojciech Braksator, Filip M. Szymanski, Marek Chmielewski, Joanna Syska-Suminska, Miroslaw Dluzniewski
Journal: Journal of the American College of Cardiology (2013)
PKC δ-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells
Authors: A SKALETZROROWSKI, H ESCHERT, J LENG, B STALLMEYER, J SINDERMANN, E PULAWSKI, G BREITHARDT
Journal: Cardiovascular Research (2005)

Objective: Basic fibroblast growth factor (bFGF)-stimulated proliferation of coronary smooth muscle cells (cSMC) contributes to the pathogenesis of arteriosclerosis and restenosis. However, the molecular mechanisms involved are not fully understood. We have shown previously that protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) are required for the bFGF-stimulated mitogenic process in bovine cSMC. In this study, we determined the PKC isoform(s) involved and investigated their functional role in the bFGF-stimulated signaling and cell cycle progression in human and bovine cSMC. Methods and Results: Downregulation of PKC by phorbol 12-myristate 13-acetate (PMA) inhibited bFGF-induced DNA synthesis, the activation of MAPK, and the expression of c-myc, demonstrating the involvement of PMA-sensitive PKC isoforms in growth factor-induced proliferation and the MAPK pathway. The PMA-sensitive classical PKC isoforms α, β, γand novel PKC isoforms δ and ε were found in human cSMC. Whereas blocking of the classical PKC isoforms had no influence, the suppression of PKC δ by genetic and pharmacological approaches inhibited the bFGF-stimulated c-Raf1–MEK–MAPK–c-myc signaling and DNA synthesis in cSMC. In contrast to PKC ε, our results showed that bFGF activated PKC δ by phosphorylation in a time-dependent manner. In addition, inhibition of PKC δ induced a hypophosphorylation of the retinoblastoma protein and suppression of the cyclins D1 and A, demonstrating the importance of PKC δ for bFGF-induced cell cycle progression through the G1 phase in cSMC. Conclusions: Our results show that PKC δ is required for the bFGF-stimulated c-Raf1–MEK–MAPK–c-myc signaling pathway involved in the proliferation of cSMC. Therefore, it may be an interesting therapeutic target for preventing proliferative vascular disorders.
Chromosomal aberrations and bone marrow toxicity.
Authors: J A Heddle, M F Salamone
Journal: Environmental Health Perspectives (1981)

The importance of chromosomal aberrations as a proximate cause of bone marrow toxicity is discussed. Since chemicals that can cause nondisjunction are rare, numerical aberrations (aneuploidy, polyploidy) are not ordinarily important. Many structural aberrations, however, can lead directly to cell death and so are proximate causes of toxicity when they occur. The micronucleus test which utilizes the polychromatic erythrocyte is capable of detecting agents (clastogens) that can cause such structural aberrations. Many carcinogens can be detected by this test, and recent changes in the protocol may increase the success rate. Nevertheless only a small proportion of chemicals are clastogens. The importance of cell division in the expression of chromosomal damage and the stage of the cell cycle at the time of exposure on the amount of damage is emphasized. A speculative mechanism for the relationship between chromosomal aberrations and carcinogenicity is proposed.
Consultant and Specialist Services
Authors: H. Bailey
Journal: BMJ (1944)

<h3>Introduction/Background</h3> Borderline ovarian tumors (BOT) are defined as atypical epithelial proliferation without histopathological stromal invasion. Tumors with low malignancy potential, tend to be limited to ovary and CA 125 is not elevated in majority of patients. In this study, we aim to investigate CA 125 levels in patients with BOT. <h3>Methodology</h3> 56 patients, final pathologies were reported as BOT were included. Age, menapausal status, histological type and stage of the tumor were evaluated and compared with CA 125 levels, retrospectively. <h3>Results</h3> The mean age of the patients was 42.9 (19–84) and 66.1% of the patients were premenapausal. Serous histology was detected in 67.9% of the patients, the remaining histology was musinous, brenner or mix type. 83.9% of the patients disease was limited to the ovary. 57.1% of the patients Ca 125 levels were above normal range. Mean level of CA 125 was 227.2 U/ml, ranged between 3–5668 U/ml (table 1). There was positive corelation between CA 125 levels and premenapausal status, serous histology and extraovarian spread (table 2). <h3>Conclusion</h3> CA 125 is especially used in monitoring the response to treatment in invasive epithelial ovarian cancer. In early stage disease and in premenopausal women its benefits are limited. It is reported that there isn’t a significant increase in CA 125 in BOT. However, in our study, elevation in CA 125 level was found in a significant number of patients and it was related to stage and serous histology, and higher levels were detected in the majority of premenopausal patients. This suggests that detection of CA 125 levels in BOT may have prognostic significance in addition to assisting the diagnosis. <h3>Disclosure</h3> Nothing to disclose.
Psychotherapy East and West
Authors: Jurgen Ruesch
Journal: JAMA (1962)

The author, by profession minister, philosopher, writer, and teacher, has for many years been an outstanding interpreter of Asian thinking. In this book, he raises the problem of the therapeutically effective process, and compares the liberation procedures of Buddhism, Taoism, Vedanta, and Yoga to the Western psychological and psychiatric methods of psychotherapy and psychoanalysis. The search for a common denominator is presented in 6 chapters in which philosophical, cultural, social, and psychological considerations are tightly interwoven. The book is well documented and contains many original quotations; it is easily readable and full of pearls of wisdom. However, it is not recommended for the man who is easily disturbed when the underpinnings of his existence are examined too closely. He had best put the book aside with the statement, "just philosophy." However, the professional who seeks an understanding of modern psychological man will find this book enlightening, entertaining, and brief in