tbuckley/cabot-search huggingface dataset:
Appendiceal mucocele presenting with lower abdominal pain
Authors: J. Chou, C. Feng, H. Lai
Journal: Endoscopy (2009)

A 57-year-old man was referred to our hospital with a 3-day history of right lower abdominal pain. He denied having fever, bloody stool, or weight loss. An abdominal ultrasound carried out elsewhere demonstrated a mass lesion in the right lower abdomen. On examination the right lower abdomen was tender without muscle guarding or rebound tenderness. The results of laboratory tests showed unremarkable abnormalities. An abdominal computed tomography (CT) scan demonstrated a 3-cm tumor in the region of the cecum, adjacent to the ileocecal valve ([Fig. 1]). A subsequent colonoscopy demonstrated an erythematous, soft mass with a central crater, located in the site of the appendix ([Fig. 2]). The patient was referred to the department of surgery for a laparotomy. At laparotomy, a tumor, 3 × 3 × 5 cm in size, was identified in the appendiceal area, adherent to the cecum and the terminal ileum. Histopathological examination of the resected tumor revealed multiple foci of mucin deposits without epithelial cells ([Fig. 3]). On the basis of the pathological findings, a diagnosis of appendiceal mucocele was made.
Knuckle Pads, Leukonychia and Deafness
Authors: Robert S. Bart, Robert E. Pumphrey
Journal: New England Journal of Medicine (1967)

THE present report concerns a family in which knuckle pads, mixed hearing loss (sensorineural and conductive) and total leukonychia (white nails) are inherited together, following the principles of dominant mendelian genetics. To our knowledge, this hereditary syndrome has not previously been reported.Case ReportsCase 1. The proposita, E.J.H., an 11-year-old girl, 1 of 4 siblings, was first seen because of a mild pyoderma and possible atopic dermatitis of the upper extremities, both of which responded to topical therapy. It was noted that she had firm, though not markedly hyperkeratotic, thickened skin over almost all the interphalangeal joints of the . . .
Mite fauna of German farms
Authors: J.‐Th. Franz, G. Masuch, H. Müsken, K.‐Ch. Bergmann
Journal: Allergy (1997)

Storage mites are important sources of airborne allergens, especially on farms. A mite survey was conducted in the working environments of 121 farms in five regions of Germany. Of 859 samples, 743 (86.4%) contained mites, representing 547,857 astigmatic mites in 723 g of dust and 34,501 prostigmatic mites in 469 g of dust. Dust samples from nine sites of each farm were collected and analyzed. Ninety-three percent of all mites belonged to the order Astigmata (storage- and house-dust-mite species); 35 Astigmata and 14 Prostigmata mite species were identified. According to the abundance and steadiness of the important astigmatic mite species, the following order was found: Lepidoglyphus destructor > Glycyphagus domesticus > Acarus siro > Tyrophagus longior > Blomia tjibodas > Chortoglyphus arcuatus > Thyreophagus entomophagus > Tyrophagus putrescentiae > Euroglyphus longior > Tyrophagus palmarum > Acarus farris > Acarus immobilis > Gohieria fusca. Blomia tjibodas was described for the first time as an abundant species of farms in Germany.
Treated Pagetʼs Disease of Bone Mimicking Metastatic Cancer
Authors: WILL G. RYAN, ERNEST W. FORDHAM, AMJAD ALI
Journal: Clinical Nuclear Medicine (1995)

A 60-year-old man with extensive, treatment resistant Paget's disease of bone causing spinal neural compression, was treated with three courses of plicamycin and vinblastine between July and December 1986. The result of a follow-up bone scan with Tc-99m MBP in January 1990 was suggestive of metastatic cancer. Roentgenographic evaluation revealed only residual Paget's disease. The patient showed no evidence of cancer in subsequent follow-up.
Detecting differences in quality of care: the sensitivity of measures of process and outcome in treating acute myocardial infarction
Authors: J. Mant, N. Hicks
Journal: BMJ (1995)

The merits or otherwise of publishing hospital specific death rates are much debated.This article compares the relative sensitivity of measures of process and outcome to differences in quality ofcare for the hospital treatment of myocardial infarction.Aspects of hospital care that have a proved impact on mortality from myocardial infarction are identified, and the results from meta-analysis and large randomised controlled trials are used to estimate the impact that optimal use of these inter- ventions would have on mortality in a typical district general hospital.Sample size calculations are then performed to determine how many years of data would be needed to detect significant differences between hospitals.A comparison is then made with the amount of data that would be needed to detect significant differences if information about process of care was being collected.Process measures based on the results of randomised controlled trials were found to be able to detect relevant differences between hospitals that would not be identified by comparing hospital specific mortality, which is an insensitive indicator ofthe quality ofcare.
The proportion of CD34+CD38low or neg myeloblasts, but not side population frequency, predicts initial response to induction therapy in patients with newly diagnosed acute myeloid leukemia
Authors: M Roshal, S Chien, M Othus, B L Wood, M Fang, F R Appelbaum, E H Estey, T Papayannopoulou, P S Becker
Journal: Leukemia (2012)
Containment of SARS depends on how it is handled in China
Authors: J. Parry
Journal: BMJ (2003)

The outbreak of severe acute respiratory syndrome (SARS) has yet to peak in China, according to the World Health Organization, which has said that worldwide containment of the disease depends on how it is handled there.

“We are looking at this as a medium term disease. China could seed the rest of the world with SARS,” said Peter Cordingley, WHO's spokesman in Manila. By 5 May, of the global total of 6583 reported probable cases, 65% were in China, as were 44% of the deaths.

In Guangdong province less than 150 of the total 1441 reported cases were still in hospital by 5 May, but in Beijing over 80% of cases are current and nearly 20% of the 1897 cases have occurred among health workers. The quarantine orders on over 16 000 …
A double‐blind comparison of inhaled budesonide, long‐acting theophylline, and their combination in treatment of nocturnal asthma
Authors: P. Youngchaiyud, C. Permpikui, T. Suthamsmai, E. Wong
Journal: Allergy (1995)

In 61 patients with nocturnal asthma, the effects of budesonide, an inhaled steroid (Pulmicort®; 200 μg twice daily), long‐acting theophylline (Theodur®; 200 mg twice daily), and their combination were compared. After a 2‐week placebo run‐in period, the patients were entered into double‐blind, crossover periods of 3 weeks. Patients were allowed to use inhaled β 2 ‐agonists as required throughout the study. Morning and evening peak expiratory flow rate (PEFR) (percentage of predicted normal ± SEM) was significantly higher during the budesonide (morning 77 ± 1%; evening 80 ± 1%) and combination therapy (morning 79 ± 1%; evening 81 ± 1%) than the theophylline treatment (morning 74 ± 1%; evening 76 ± 1; P ≤0.01, respectively). Significantly fewer sleep disturbances and fewer nighttime inhalations of β 2 ‐agonists were required during budesonide and combination therapy than theophylline treatment. No statistically significant differences were seen between combined therapy and budesonide alone. Budesonide, an inhaled steroid, was significantly better than the bronchodilator, theophylline, in controlling nocturnal asthma, but no additional improvement in efficacy was seen when the drugs were used in combination.
Localized and Systemic Approaches to Treating Hepatocellular Carcinoma
Authors: Jennifer J. Knox, Sean P. Cleary, Laura A. Dawson
Journal: Journal of Clinical Oncology (2015)

Article Tools REVIEW ARTICLES Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2014.60.1153 Journal of Clinical Oncology - published online before print April 27, 2015 PMID: 25918289 Localized and Systemic Approaches to Treating Hepatocellular Carcinoma Jennifer J. KnoxxJennifer J. KnoxSearch for articles by this author , Sean P. ClearyxSean P. ClearySearch for articles by this author , Laura A. DawsonxLaura A. DawsonSearch for articles by this author Show More All authors: University of Toronto, Princess Margaret Cancer Centre, Toronto, ON, Canada. https://doi.org/10.1200/JCO.2014.60.1153 First Page Full Text PDF Figures and Tables © 2015 by American Society of Clinical Oncology
Reactive arthritis associated with campylobacter enteritis.
Authors: C J Eastmond, T M Reid, J A Rennie
Journal: Annals of the Rheumatic Diseases (1981)

advising other departments on the development of their services and how to manage individual problems.The subtle denigration of which you speak is a consequence of the present structure in which rheumatologists are often asked to take over the care of another specialist's patients when they feel they can do no more.The process of rehabilitation should start from the time the patient is first seen and requires an attitude of mind by all members of the clinical team.You know that I am an active supporter of the development of the specialty of rehabilitation.I believe that the best way forward is the emergence of the specialty of rehabilitation in its own right rather than as an appendage to rheunratology.
Abstract 2537: The novel sphingosine kinase inhibitor ABC294640 blocks survival and tumorigenesis in chemo- And endocrine resistant breast cancer
Authors: James W. Antoon, Martin D. White, Matthew M. Gestaut, Evelyn M. Slaughter, Steven Elliott, Jennifer L. Driver, Hafez S. Khalili, Charles D. Smith, Matthew E. Burow, Barbara S. Beckman
Journal: Cancer Research (2010)

Abstract Resistance to chemotherapy is a major cause of breast cancer treatment failure today. The sphingolipid metabolizing enzyme sphingosine kinase converts pro-apoptotic ceramide into pro-survival sphingosine-1-phosphate (S1P). Sphingosine kinase has been shown to be involved in breast cancer endocrine- and chemo-resistance and is proposed to be a key regulator of proliferation. Here, we studied the effects of the novel sphingosine kinase inhibitor, ABC294640 (3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl) amide), on human breast cancer and compared them to its parent compound, SKI-II (4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol). Treatment with ABC294640 increased levels of endogenous long chain ceramides while simultaneously reducing levels of S1P in vitro. ABC294640 blocked both viability and survival at low micromolar IC50 concentrations in the endocrine therapy resistant - MDA-MB-231, MDA-MB-468 and MDA-MB-361 cells, as well as the chemotherapy resistant MCF-7TN-R cell line. Furthermore, treatment with the inhibitor significantly reduced proliferation, as seen in immunofluorescence staining of Ki-67 in vitro. Interestingly, ABC294640 can induce apoptosis and release caspase-9, possibly through modulation of activity of the transcription factor NF-kappaB. Treatment with 10μM of the inhibitor blocked transcription of genes known to be mediated by the NF-kappaB, such as at IAP1, IAP2, and SOD1. Finally, utilizing xenograft immunocompromised mouse models, ABC294640 significantly reduced breast cancer tumorigenesis of MDA-MB-468 and MCF-7TN-R in vivo. Treatment with 50 mg/kg of the inhibitor for 14 days decreased MDA-MB-468 tumor volume by 37.3% (n=10) compared to vector control. Similarly, there was a 67.4% decrease in tumor volume following 18 days of treatment in the chemoresistant MCF-7TN-R xenograft mice (n=10). These results indicate that pharmacological inhibition of sphingosine kinase with an orally bioavailable selective inhibitor, ABC294640, has therapeutic potential in the treatment of chemo- and endocrine therapy- resistant breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2537.
Atlas of Neuropathology
Authors: Charles B. Wilson
Journal: JAMA (1972)

<b>Atlas of the Histology of Brain Tumors</b>, by Klaus J. Zülch, 261 pp, 100 illus, $22.60, New York: Springer-Verlag, 1971. An atlas should provide a pictorial guide to the learning of a particular subject, and it rises or falls on the selection and quality of reproduced material. While the reviewer recognizes the need for a current atlas of neuropathology, Zack's fails to meet this objective. The atlas contains sections with the following headings: cellular neuropathology, vascular disease, trauma, infections, diseases of myelin, hydrocephalus, degenerative diseases, metabolic diseases, tumors, dysgenetic syndromes, and diseases of skeletal muscle and peripheral nerve. Each section begins with a short introductory text, followed by clinical summaries facing each plate. References placed at the end of each section guide the reader to original descriptions and major review articles. The prospective buyer will object to the large number of nearly blank pages. The author's selection of gross specimens,
Serum biomarkers are similar in <scp>C</scp>hurg–<scp>S</scp>trauss syndrome and hypereosinophilic syndrome
Authors: P. Khoury, P. Zagallo, C. Talar‐Williams, C. S. Santos, E. Dinerman, N. C. Holland, A. D. Klion
Journal: Allergy (2012)

Abstract Rationale Churg–Strauss syndrome ( CSS ) and hypereosinophilic syndrome ( HES ) overlap considerably in clinical presentation. A reliable means of distinguishing between these groups of patients is needed, especially in the setting of glucocorticoid therapy. Methods A retrospective chart review of 276 adult subjects referred for evaluation of eosinophilia &gt; 1500/μl was performed, and subjects with a documented secondary cause of eosinophilia or a PDGFR ‐positive myeloproliferative neoplasm were excluded. The remaining subjects were assessed for the presence of American College of Rheumatology ( ACR ) criteria. Laboratory and clinical parameters were compared between subjects with biopsy‐proven vasculitis ( CSS ; n = 8), ≥4 ACR criteria (probable CSS ; n = 21), HES with asthma and/or sinusitis without other CSS ‐defining criteria ( HES w AS ; n = 20), HES without asthma or sinusitis ( HES ; n = 18), and normal controls ( n = 8). Serum biomarkers reported to be associated with CSS were measured using standard techniques. Results There were no differences between the subjects with definite or probable CSS or HES with respect to age, gender, or maintenance steroid dose. Serum CCL 17, IL ‐8, and eotaxin levels were significantly increased in eosinophilic subjects as compared to normal controls, but were similar between the eosinophilic groups. Serum CCL 17 correlated with eosinophil count ( P &lt; 0.0001, r = 0.73), but not with prednisone dose. Conclusions In patients with a history of asthma and sinusitis, distinguishing between ANCA ‐negative CSS and PDGFR ‐ne‐gative HES is difficult because of significant overlap in clinical presentation and biomarker profiles.
Pilot Study to Assess the Influence of β-Blockade on Mitral Regurgitant Volume and Left Ventricular Work in Degenerative Mitral Valve Disease
Authors: Ralph A.H. Stewart, Owen C. Raffel, Andrew J. Kerr, Ruvin Gabriel, Irene Zeng, Alistair A. Young, Brett R. Cowan
Journal: Circulation (2008)

Background— A medical treatment that decreases the likelihood of left ventricular (LV) dysfunction or symptoms would benefit patients with moderate to severe degenerative mitral regurgitation. The aim of this pilot study was to determine the short-term effects of a β-blocker on mitral regurgitant volume and LV work in these patients. Methods and Results— Twenty-five patients with moderate or severe degenerative mitral regurgitation were randomized in a double-blind crossover study to the β 1 -selective adrenergic blocker metoprolol (mean daily dose, 119 mg; range 23.75 to 190 mg) and placebo for 14±3 days. At the end of each treatment period, ascending aortic flow and LV stroke volume were measured by cardiac magnetic resonance imaging, and mitral regurgitant volume was calculated. On β-blocker, heart rate decreased from 65±10 by 10±7 bpm (mean±SD) and systolic blood pressure decreased from 138±18 by 16±12 mm Hg ( P &lt;0.0001 for both). No significant change occurred in LV ejection fraction (from 65±5%; change, −0.6±2.7%; P =0.3) or mitral regurgitant volume (from 59±36 mL; change, 3±13 mL; P =0.3), but forward stroke volume increased from 89±21 by 5±11 mL ( P =0.03). Because heart rate was lower on metoprolol, cardiac output decreased from 5.68±1.04 by 0.56±0.78 L/min ( P =0.001), but a greater decrease occurred in LV output, from 9.51±2.22 by 1.30±1.08 L/min ( P &lt;0.0001). Mitral regurgitant volume per minute decreased from 3.83±2.41 by 0.74±1.00 L/min ( P =0.001). The decrease in LV work on β-blocker (mean, 21%; 95% confidence interval, 15 to 27) was greater ( P =0.001) than the decrease in cardiac output (mean, 9%; 95% confidence interval, 3 to 15). Conclusions— In this pilot study, short-term treatment with a β-blocker did not change mitral regurgitant volume per beat but decreased LV work in patients with moderate to severe degenerative mitral regurgitation. Further research is needed to determine whether longer-term treatment with β-blockers will decrease progressive LV dysfunction and symptomatic deterioration.
Diagnostic Value of Marrow Hemosiderin Patterns
Authors: ROBERT K. NIXON
Journal: Annals of Internal Medicine (1968)

Marrow hemosiderin patterns in 500 patients were analyzed to determine their diagnostic value. The quantity and predominant particle size of iron was evaluated. In each type of anemia studied (iron lack, primary or secondary refractory, hemolytic, post-hemorrhagic, and vitamin B12 deficiency) excellent correlation of the hemosiderin pattern with known ferrokinetics was obtained. Confirmation of the previously reported finding of absence of marrow iron in polycythemia vera was made in all cases studied. Furthermore, a hemosiderin pattern that differs from that of cirrhosis due to other causes was observed in primary hemochromatosis. It is concluded that direct visualization of marrow hemosiderin patterns provides an accurate, rapid, and simple means of evaluating iron dynamics. In additon to offering a rational basis for the clinical study of anemias, the procedure is useful in the initial diagnostic approach to polycythemias. Results to date suggest that hemosiderin patterns may be of singular aid in the differentiation of primary hemochromatosis and cirrhosis. In contrast to ferrokinetic studies, the simplicity of marrow hemosiderin evaluation lends itself to routine application.
Sports Eye Injuries A Model for Prevention
Authors: Paul Vinger
Journal: JAMA (1983)

The leadership role that physicians can assume in combating sports-related injuries is clearly demonstrated by the experience in ice hockey. One of the most efficient protective devices in sport to date is the hockey face mask. With the increase in the sport's popularity, particularly in schools and colleges, eye injuries to ice hockey players rose dramatically during the 1960s and 1970s. Working through the Canadian Standards Association (CSA) and the American Society of Testing and Materials (ASTM), ophthalmologists in Canada and the United States collected data documenting the problem, directed development of performance standards for hockey face masks, successfully lobbied hockey organizations to require that players wear face masks meeting the standards, and educated players about the importance of face masks.<sup>1,2</sup> This work was funded, for the most part, by volunteers whose goal was to make ice hockey safer without changing its fast action or basic style. Now, on
Effects of Unilateral Nephrectomy and Mixed Infection on Blood Pressure of Rats with Experimental Chronic Pyelonephritis
Authors: ALVIN P. SHAPIRO, JEAN L. KOBERNICK, CALVIN C. BLAIR
Journal: Circulation Research (1959)

Chronic pyelonephritis resulting from a mixed infection was produced in rats. They displayed marked hyposthenuria and azotemia and, on pathologic examination at the end of one year, revealed severe contraction and scarring of the kidneys. Hypertensive vascular disease did not develop even in rats with unilateral nephrectomy, although some animals succumbed to renal failure. The results indicate that parenchymal renal injury from chronic renal infection, even when it results from mixed infection and is associated with a decrease in renal mass, does not result in hypertensive disease. It is suggested that this is due to the absence of a vascular lesion producing renal ischemia.
Alkaline Phosphatase Isoenzyme Patterns in Hyperthyroidism
Authors: DAVID S. COOPER
Journal: Annals of Internal Medicine (1979)

Fifteen of 36 hyperthyroid patients had elevations in serum alkaline phosphatase activity. There was no difference in mean thyroxine (T4), triiodothyronine (T3), age, or duration of illness between the groups with high alkaline phosphatase and normal alkaline phosphatase levels. After treatment, serum alkaline phosphatase levels rose as T4 levels declined; at 3 months, the mean serum alkaline phosphatase value rose from 7.1 Bodansky units to 10.3 Bodansky units (P < 0.005), while the mean T4 value fell from 18 µg/dl to 7.2 µg/dl (P < 0.005). In some patients, serum alkaline phosphatase values have remained elevated for more than 1 year, despite continued normality in thyroid variables. Before therapy, isoenzyme patterns analyzed by polyacrylamide gel electrophoresis were qualitatively normal. As therapy was instituted, the isoenzyme patterns changed markedly, with increased amounts of bone alkaline phosphatase appearing in the serum as T4 levels were declining and total alkaline phosphatase was rising. Thyroid tissue homogenates from patients with Graves' disease were found to have very low levels of alkaline phosphatase activity and an isoenzyme pattern quite distinct from that found in the serum.
Modern Hospital Asepsis from an Interne's Viewpoint.
Authors: John C. Hollister
Journal: JAMA (1905)

Chicago, Dec. 21, 1904. <h3>To the Editor:</h3> —It seems almost superfluous and uncalled for to try to bring out anything more relative to asepsis in the modern hospital and operating room of to-day, but with the exception of a hint of them now and then to be seen in various articles in some of the later journals, no one has touched on two or three points that should be strongly emphasized and criticised, and the causes of which should be eliminated in order to get better aseptic surgical results. One would think on close examination of one of the newer operating rooms that every precaution had been taken, that every means known to bacteriology had been or was constantly being employed to destroy the bacteria that had already gained entrance to the operative field and its environment and to prevent any further contamination. The room as a whole is built
Do Specialists Expect Too Much From GP's?
Authors: H. Paul Johnson
Journal: JAMA (1964)

<h3>To the Editor:—</h3> The number of "musts" listed in theJournalcommunication, "Is Noise the Bane of Life?" (<b>187</b>, Jan 25, adv p 36), are certainly worthy of consideration, but I wonder how often physicians engaged in limited fields of practice really appreciate to what extent those not so engaged are expected to comprehend and to exercise good judgment in the face of ever-increasing demands from every phase of medicine. I recall that, as a young physician in a period when the amount of fundamental and clinical data was considerably less, I heard an address by an eminent specialist in which he stressed five or six points which, if kept in mind by the general physician, would help him avoid difficulty. One listener asked the speaker if he had ever considered multiplying these relatively simple points by the number of specialties. The situation if multiplied many times obviously is much