tbuckley/cabot-search huggingface dataset:
Should reviewers of papers have their names published?: Reviewing is not vicarious authorship
Authors: Sean P J Lynch
Journal: BMJ (2004)

Editor-Despite research in tropical medicine being undertaken in countries from low human development index, authorship and editorial opinion remain with countries from higher development index.This unfair trend observed by Keiser et al demands to be addressed and overturned. 1 This observed bias may arise because countries of high human development index fund the bulk of research in tropical medicine. 2 3Authors from these countries have prepared the grant applications, taken principal investigator status, and believe that they should take primary or terminal authorship.Researchers from low human development index countries can break this cycle only if they can obtain international funding themselves or are allowed authorship by the principal investigators.It seems this is rarely extended to the collaborators in tropical countries, even though they are the ones practically conducting the study.If such generosity in authorship and mentorship were provided, this would enable researchers from low human devel-
Enterovirus-induced fulminant myocarditis and hemophagocytic syndrome
Authors: Konstantinos P. Letsas, Gerasimos S. Filippatos, Sossana Delimpasi, Nicholas Spanakis, Stavros P. Kounas, Michalis Efremidis, Athanassios Tsakris, Fotios Kardaras
Journal: Journal of Infection (2006)
Fibre glass induced synovitis.
Authors: L G Cleland, B Vernon-Roberts, K Smith
Journal: Annals of the Rheumatic Diseases (1984)

Chronic synovitis developed in the dorsal extensor sheath of the hand of a 25-year-old manufacturer of fibre glass reinforced boats and surfboards . Particles found in synovial fluid aspirates were similar in morphology and elemental content to unused fibre glass and particles found in dust from the workshop floor. It was concluded that hard disc grinding required during manufacture resulted in percutaneous implantation of small glass particles, leading to chronic synovitis and effusion.
Cutaneous infiltration in T-cell prolymphocytic leukaemia
Authors: R.B. MALLETT, E. MATUTES, D. CATOVSKY, K. MACLENNAN, P.S. MORTIMER, C.A. HOLDEN
Journal: British Journal of Dermatology (2006)

T-cell prolymphocytic leukaemia (T-PLL) is an aggressive leukaemia accounting for over 30% of all mature T-cell malignancies. We describe the clinical manifestations and histology of cutaneous involvement in a series of 92 patients with T-PLL. Of the 92 patients, 26 (28%) had cutaneous involvement, and in 23 this was present at the time of the diagnosis of the leukaemia. Skin manifestations included a diffuse infiltrated erythema, infiltration localized to the face and ears, nodules and erythroderma. Histology showed a perivascular and periappendageal dermal infiltrate of lymphoid cells with the morphology of prolymphocytes. An early skin biopsy in these patients should help to reveal the underlying diagnosis.
TCT-700 Multicenter Evaluation of Transcatheter Aortic Valve Replacement Using either SAPIEN XT or CoreValve: Degree of Device Oversizing and Clinical Outcomes
Authors: Danny Dvir, John Webb, Marco Barbanti, Tae-Hyun Yang, Sabine Bleiziffer, David A. Wood, darren mylotte, Sebastiano Immè, Adam J. Berger, Yohei Ohno, Guilherme F. Attizzani, carmelo sgroi, Philipp Blanke, Rekha Raju, Dion Stub, Bruce Precious, Corrado Tamburino, Rudiger Lange, Jonathon A. Leipsic
Journal: Journal of the American College of Cardiology (2014)
Differential H1- and H2-receptor-mediated histamine responses of canine epicardial conductance and distal resistance coronary vessels.
Authors: W L Miller, A A Bove
Journal: Circulation Research (1988)

The contributions of histamine (H1 or H2) receptor-mediated responses and, therefore, the effects of histamine blocking agents are unclear with regard to regulation of proximal epicardial and distal resistance coronary arteries. This study was designed to evaluate the effects of selective H1- and H2-receptor antagonists on epicardial and resistance vessels in the closed chest dog model. Histamine, diphenhydramine (H1 blocker), and cimetidine (H2 blocker) were infused into the left anterior descending coronary artery (LAD), and responses were studied by quantitative coronary angiography and flow measurements (133Xe washout). Histamine infusion alone produced a significant dilation of the proximal LAD (13% above control) only at the highest dose (45 micrograms/min), while LAD flow was increased by 128%. In the presence of H1 blocker, histamine produced significantly greater epicardial dilation (55% above control). The flow response curve was shifted to the right in the presence of H1 blocker, but the flow attenuation was overcome by the highest histamine dose. In contrast, the H2 blocker attenuated both epicardial dilation (6% below control) and flow response (31% above control) to the highest histamine dose. Results support a differential regulation of proximal epicardial and distal resistance vessels to histamine with epicardial arteries demonstrating H1-mediated vasoconstriction and H2-mediated vasodilation and distal resistance vessels showing H1- and H2-mediated vasodilation. In addition, these findings suggest that H1 blockade may antagonize histamine-related vasoconstriction and vasospasm, while H2 blockers may permit unopposed H1-mediated vasoconstriction of epicardial arteries and also limit resistance vessel vasodilatory responsiveness in the presence of elevated tissue histamine, as may occur in atherosclerotic coronary artery disease.
HYPERTROPHY OF THE PHARYNGEAL OR LUSCHKA'S TONSIL.Read in the Section on Laryngology and Otology, at the Forty-fifth Annual Meeting of the American Medical Association, held at San Francisco. June 5-8. 1894.
Authors: E. FLETCHER INGALS
Journal: JAMA (1894)

Hypertrophy of the pharyngeal or Luschka's tonsil, by some authors termed adenoid growths, consists of an abnormal enlargement of the glandular tissues normally found in the vault and walls of the pharynx. It is characterized by obstruction of nasal respiration, with catarrhal symptoms and in many cases partial deafness, with alterations in the voice partially due to obstruction of the resonant chamber in the posterior nares, and partially to changes in the larynx caused by mouth-breathing. There is also more or less deterioration of the general health, and frequently deformity of the chest; in many instances mental hebetude and imperfect physical development are very pronounced. Attention was first directed to this condition by Meyer, of Copenhagen, in 1860, and later by Loewenberg, of Paris, who reported three cases in 1865. The same author subsequently published a complete<i>résumé</i>of the subject in 1879. A thorough discussion of the subject was
The slipperiness of futility
Authors: D. K Sokol
Journal: BMJ (2009)

When clinicians deem an intervention to be futile, what do they actually mean?

He was shot in the back. The surgeons could not save him. He lay in bed, unconscious, his life ebbing away as blood trickled down tubes to large jars at the base of his bed. As cardiopulmonary resuscitation would have been futile, we wrote a “Do not attempt resuscitation” order. The case reminded me of the etymology of the word “futile.” “Futilis” in Latin means “leaky.” The patient was leaking blood from various wounds, and nothing could stop it.

At a recent examiners’ meeting, a professor of surgery admitted that he would have got the ethics question wrong. The question concerned the definition of futility. “So how would you define futility?” I asked. He paused and, like Humpty Dumpty in Through the Looking Glass , answered: “Something is futile if I say it is.” This remark highlights the semantic slipperiness and subjectivity of the term “futile.” Yet, in the clinical frontline, futility, coated with a veneer of objectivity, is often used as a moral trump card, a dismissive pronouncement to end all discussion: “I’m sorry. …
Spontaneous arrhythmias in various models of cardiac hypertrophy and senescence of rats. A Holter monitoring study
Authors: F. Carre, Y. Lessard, P. Coumel, L. Ollivier, S. Besse, Y. Lecarpentier, B. Swynghedauw
Journal: Cardiovascular Research (1992)

The aim was to define experimental models of spontaneous arrhythmias in various models of cardiac hypertrophy in rats.Cardiac hypertrophy was induced by several methods and 24 h Holter monitoring was recorded in conscious rats to quantify spontaneous arrhythmias in hypertrophied hearts. Male Wistar rats were studied. A group of young controls 1-2 months old (n = 16) was compared to four groups of animals with cardiac hypertrophy: (1) thyrotoxic rats which received a daily intraperitoneal injection of L-thyroxine for 7 d (n = 6); (2) rats subjected to abdominal suprarenal aortic stenosis (n = 11); (3) senescent rats 22-24 month old (n = 6); and (4) S-DOCA-salt (senescent animals rendered hypertensive by uninephrectomy and DOCA-salt treatment, n = 8).(1) Thyroxine resulted in 20% cardiac hypertrophy, with normal arterial tension, sinus tachycardia, a shorter P wave length and PR interval, and frequent (5/6) atrioventricular block. No premature beats were seen. (2) In aortic stenosis, atria and left ventricle were hypertrophied by 53% and systolic carotid pressure increased by 63%. The incidence of supraventricular premature beats was increased [frequency = 0.70 (SEM 0.3) per 24 h in control v 99(61) in aortic stenosis, p < 0.05]. Ventricular premature beats remained as rare as in control. (3) In senescent and S-DOCA-salt rats all types of spontaneous arrhythmias, but specially supraventricular arrhythmias and atrioventricular block, were frequent. Cardiac hypertrophy produced by DOCA-salt treatment in senescent rats had no effect on the incidence and nature of arrhythmias, but resulted in an increased QTc interval.Senescent rats and rats with aortic stenosis represent valid models of spontaneous arrhythmias occurring in the absence of ischaemia or toxic insult. Spontaneous arrhythmias in rats are mainly of supraventricular origin. Hyperthyroidism in rats is a model of atrioventricular block probably related to tachycardia. Holter monitoring in rats may have several potential pathophysiological and pharmacological applications.
The use of laminin modified linear ordered collagen scaffolds loaded with laminin-binding ciliary neurotrophic factor for sciatic nerve regeneration in rats
Authors: Jiani Cao, Changkai Sun, Hui Zhao, Zhifeng Xiao, Bing Chen, Jian Gao, Tiezheng Zheng, Wei Wu, Shuang Wu, Jingyu Wang, Jianwu Dai
Journal: Biomaterials (2011)
DIETARY PROTEIN IN HEMORRHAGIC BRIGHT'S DISEASE
Authors: E. H. Keutmann, Wm. S. McCann
Journal: Journal of Clinical Investigation (1932)

The question of the possibility of injury to the kidneys by the proteins of the diet has received the attention of a number of investigators.Recently Newburgh and coworkers have published some observations which throw new light on the problem.In 1919 Newburgh (14) reported a series of experiments in which renal injury was observed in rabbits to which high protein diets were given.In 1928 a further report (15) was made of experiments in which white rats were given 75 per cent of their diet in the form of proteins, either as liver, or as beef muscle, or as casein.Renal injury was noted in all groups after varying lengths of time.In the group receiving liver, the kidneys at autopsy were enlarged, granular and characterized by both glomerular and tubular lesions and fibrosis.These changes were well marked at the end of "less than a year" of the liver diet.In the case of casein the renal injury was least marked, being confined to the tubules, and required the longest time for its production, while the lesions occurring in the group receiving beef muscle were intermediate between the two extremes both in degree and in the rapidity of their production.In a more recent report Newburgh (16) expressed the belief that the difference in results obtained in previous work was due to the nephrotoxic effects of products of nuclear material and not to the proteins per se, since feeding of sodium nucleate produced hematuria.He was able to produce kidney injury with less than 75 per cent of liver in 80 per cent of the animals.Other workers have reported the production of renal lesions in animals by the feeding of high protein diets.These include Osborne, Mendel, Park and Winternitz (17), and Polvogt, McCollum and Simmonds (18).On the other hand Drummond, Crowden, and Hill (5), Jackson and Riggs (7), and Addis, MacKay and MacKay (3) failed to find renal injury in similar experiments.MacLean, Smith and Urquhart (12) were able to produce renal injury in rabbits by means of high protein diets only when green leaves and vegetables were omitted from the diet.
IMPACT OF BLEEDING ON THE LONG-TERM OUTCOMES AFTER DRUG -ELUTING STENT IMPLANTATION IN THE REAL-WORLD PRACTICE
Authors: Young-Hak Kim, Jong-Young Lee, Won-Jang Kim, Sung-Cheol Yun, Jung-Min Ahn, Junhyok Oh, Haegeun Song, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2010)
Increased lymphocyte infiltration in duodenal mucosa from patients with psoriasis and serum IgA antibodies to gliadin
Authors: G. MICHAELSSON, W. KRAAZ, B. GERDEN, E. HAGFORSEN, G. HJELMQVIST, L. LOOF, O. SJOBERG, A. SCHEYNIUS
Journal: British Journal of Dermatology (1995)

Journal Article Increased lymphocyte infiltration in duodenal mucosa from patients with psoriasis and serum IgA antibodies to gliadin Get access G. MICHAËLSSON, G. MICHAËLSSON Department of Dermatology, University Hospital, S 751 85 Uppsala, Sweden Search for other works by this author on: Oxford Academic Google Scholar W. KRAAZ, W. KRAAZ Department of Pathology, University Hospital, S 751 85 Uppsala, Sweden Search for other works by this author on: Oxford Academic Google Scholar B. GERDÉN, B. GERDÉN Department of Dermatology, University Hospital, S 751 85 Uppsala, Sweden Search for other works by this author on: Oxford Academic Google Scholar E. HAGFORSEN, E. HAGFORSEN Department of Dermatology, University Hospital, S 751 85 Uppsala, Sweden Search for other works by this author on: Oxford Academic Google Scholar G. HJELMQVIST, G. HJELMQVIST Department of Medicine, University Hospital, S 751 85 Uppsala, Sweden Search for other works by this author on: Oxford Academic Google Scholar L. LÖÖF, L. LÖÖF Department of Medicine, University Hospital, S 751 85 Uppsala, Sweden Search for other works by this author on: Oxford Academic Google Scholar O. SJÖBERG, O. SJÖBERG Department of Clinical Immunology, University Hospital, S 751 85 Uppsala, Sweden Search for other works by this author on: Oxford Academic Google Scholar A. SCHEYNIUS A. SCHEYNIUS Department of Clinical Immunology, Karolinska Hospital, Stockholm, Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 133, Issue 6, 1 December 1995, Pages 896–904, https://doi.org/10.1111/j.1365-2133.1995.tb06922.x Published: 01 December 1995 Article history Accepted: 23 January 1995 Published: 01 December 1995
Oral acyclovir prevents herpes simplex virus-associated erythema multiforme
Authors: L. MOLIN
Journal: British Journal of Dermatology (1987)

A young woman suffering from recurrent erythema multiforme associated with relapsing gluteal herpes simplex is presented, in whom long-term treatment with oral acyclovir prevented herpes episodes as well as erythema multiforme. Erythema multiforme is an acute self-limiting syndrome with distinctive skin lesions with or without mucosal lesions. An association of the syndrome with recurrent herpes simplex virus infection has been known for a long time, although the exact relationship has not been established.
Inhibitory action of adenosine on histamine- and dopamine-stimulated cardiac contractility and adenylate cyclase in guinea pigs.
Authors: G Baumann, J Schrader, E Gerlach
Journal: Circulation Research (1981)

Infusion of adenosine into the coronary arteries of isolated guinea pig hearts produced a dose-dependent inhibition of cardiac contractile force development elicited by bolus injections of histamine (7.5 X 10(-9) mol) or dopamine (1.5 X 10(-8) mol). Threshold concentration of adenosine was 10(-7) M and maximal inhibition (90%) was obtained at 3 X 10(-5) M. Adenosine in the effective concentration range did not alter Ca2+-induced increases in contractile force. The rise in tissue levels of cAMP induced by equieffective doses of histamine (7.5 X 10(-9) mol) and dopamine (1.5 X 10(-8) mol) was inhibited by adenosine (3.5 X 10(-5) M) by about 60%. In a particular membrane preparation of guinea pig ventricles the adenylate cyclase activity stimulated by the histamine (10(-5) M) and dopamine (10(-4) M) was inhibited in a dose-dependent manner by adenosine. This effect could be reversed by theophylline (5 X 10(-5) M) in a competitive manner. The hormone-insensitive adenylate cyclase of a Lubrol-PX solubilized membrane preparation stimulated by NaF or 5'-guanylylimido-diphosphate (GppNHp) was also inhibited by adenosine (40% and 90% inhibition at 10(-5) M and 10(-4) M, respectively). Adenosine did not influence the Km value of the adenylate cyclase for ATP, but markedly lowered Vmax of the enzyme. From additional studies with purine-substituted (N6-methyl-adenosine, N6-phenylisopropyl-adenosine) and ribose-substituted (2'-deoxy-adenosine and arabino-furanosyl-adenine) adenosine analogues, we conclude that adenosine may inhibit the inotropic responses to hormones as well as the adenylate cyclase activity by specifically interacting with at least two different sites associated with the adenylate cyclase.
New Online Program Offers Genetics Education
Authors: Rebecca Voelker
Journal: JAMA (2011)

or intravenous bags for multiple patients • Ensuring that reusable equipment is cleaned according to the manufacturer’s directions. The CDC is also working with outside organizations and agencies to boost clinician awareness and enhance oversight of outpatient facilities. The agency collaborated with the Safe Injection Practices Coalition, which includes the ACIP, to create a video of a continuing medical education course that clinicians can access online for free (http: //tinyurl.com/3myu229). In addition, the CDC has been working with the Centers for Medicare & Medicaid Services (CMS), which conducts inspections of outpatient facilities treating Medicare and Medicaid patients, to include the CDC’s infection control recommendations in its surveys of outpatient facilities. Bell explained that the Nevada facility where the hepatitis outbreak occurred had been inspected by the CMS shortly before the outbreak but that the surveyors were not looking at injection safety practices. Dolanencouragesalloutpatient facilities,eventhosewithexistinginfectioncontrol programs, to refer to the new CDC guide. She noted that she will be crosscheckingthechecklistsheusesatherhospital and its associated outpatient facilities with the CDC’s. “We will enhance our checklist with theirs,” she said.
Amiloride Analogs Inhibit Chronic Hypoxic Pulmonary Hypertension
Authors: DEBORAH A. QUINN, HONG-KAI DU, B. TAYLOR THOMPSON, CHARLES A. HALES
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Na+/H+ exchange regulation of intracellular pH may play a permissive role in pulmonary artery smooth muscle cell (PASM) proliferation. Our laboratory has demonstrated that dimethyl amiloride (DMA), an amiloride derivative with enhanced selectivity as an inhibitor of the Na+/H+ antiporter, can inhibit bovine PASM proliferation in vitro. We hypothesized that DMA would inhibit development of hypoxic pulmonary hypertension by interfering with PASM growth in vivo. Sprague-Dawley rats were exposed to 10% O2 for 14 d without (n = 9) or with (n = 7) DMA continuous infusion 3 mg/ kg/d. The animals treated with DMA had significant reductions in pulmonary artery pressure and total pulmonary vascular resistance index (TPVRI) when compared with hypoxic control rats (p < 0.05). Pulmonary vascular remodeling was significantly reduced in animals treated with DMA as measured by percent wall thickness and percentage of thick-walled intra-acinous vessels (p < 0.05). We used a second Na+/H+ exchange inhibitor, ethylisopropyl amiloride (EIPA, 3 mg/kg/d, n = 9), and found similar reductions in pulmonary artery pressure, TPVRI, and pulmonary vascular remodeling. Polycythemia during hypoxia was unchanged by treatment with DMA or EIPA. In conclusion, despite the hypertensive effects of polycythemia, DMA and EIPA can significantly reduce pulmonary vascular remodeling induced by chronic hypoxia.
Money available to aid nation's homeless
Authors: Phil Gunby
Journal: JAMA (1984)

Memorabilia of the Great Depression portray a time when 2 million Americans were homeless. Today, some news magazines are suggesting that, 50 years later, as many—and possibly even more—Americans have no fixed address.  The truth, says Philip W. Brickner, MD, director, Department of Community Medicine, St Vincent's Hospital and Medical Center, New York City, is that no one knows how many Americans are homeless today, although this clearly is a substantial problem. And, whatever the total, two foundations are addressing one aspect of the problem—funds for medical care for the homeless.  The two organizations—the Robert Wood Johnson Foundation, Princeton, NJ, and the Pew Memorial Trust, Philadelphia—in cosponsorship with the United States Conference of Mayors are setting up a $19.6-million program.  Coalitions of medical professionals and institutions, voluntary organizations, public agencies, and religious groups in the nation's 50 most populous cities are eligible to apply. Up to 14 will be selected
Pneumococcal vaccination after splenectomy: survey of hospital and primary care records.
Authors: P Kinnersley, C E Wilkinson, J Srinivasan
Journal: BMJ (1993)

one week of treatment with amoxycillin is no more tiring than treatment with placebo.Such a study would have no discriminatory value had it been conducted in patients with an illness inducing fatigue or requiring antibiotic treatment.Type B subjects and those with an extemal locus of control more often reported fatigue as a result of treatment.These subjects are more sensitive to the effects of outside factors, such as the intake of drugs, on their lives.Results in psychological tests are good predictors of adherence to and efficacy of treatment.4'5We have shown that the psychological profile of subjects can either increase or decrease the incidence of side effects.This idea has to be confirmed on a larger scale, but it may be important in the conception of all clinical trials.