tbuckley/cabot-search huggingface dataset:
Acrylic Bone Cement Damage
Authors: Wayne G. Elliott
Journal: JAMA (1973)

<h3>To the Editor.—</h3> I would like to add yet another complication to the acrylic bone cement hip repair as listed in theLetters to the Editor, Oct 30, 1972, issue. An elderly woman was admitted to our hospital<i>moribundus terminalis</i>some four weeks after having undergone a hip replacement at another hospital. She died soon after admission and I was called to examine the body. At autopsy, it was found that the cause of death was a massive intestinal obstruction that originated from a stricture of the ileum lying deep within the pelvis. This stricture in turn was adherent to a 1.5-cm diameter knuckle of acrylic cement that protruded from the inner surface of the acetabulum. The trauma of the acetabular perforation or the heat generated by the plastic polymerization had apparently induced the formation of the adhesion and stricture of the ileum.
A Randomized Clinical Trial of Hydroxymethylglutaryl– Coenzyme A Reductase Inhibition for Acute Lung Injury (The HARP Study)
Authors: Thelma R. Craig, Martin J. Duffy, Murali Shyamsundar, Cliona McDowell, Cecilia M. O'Kane, J. Stuart Elborn, Daniel F. McAuley
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

There is no effective pharmacological treatment for acute lung injury (ALI). Statins are a potential new therapy because they modify many of the underlying processes important in ALI.To test whether simvastatin improves physiological and biological outcomes in ALI.We conducted a randomized, double-blinded, placebo-controlled trial in patients with ALI. Patients received 80 mg simvastatin or placebo until cessation of mechanical ventilation or up to 14 days. Extravascular lung water was measured using thermodilution. Measures of pulmonary and nonpulmonary organ function were assessed daily. Pulmonary and systemic inflammation was assessed by bronchoalveolar lavage fluid and plasma cytokines. Systemic inflammation was also measured by plasma C-reactive protein.Sixty patients were recruited. Baseline characteristics, including demographics and severity of illness scores, were similar in both groups. At Day 7, there was no difference in extravascular lung water. By Day 14, the simvastatin-treated group had improvements in nonpulmonary organ dysfunction. Oxygenation and respiratory mechanics improved, although these parameters failed to reach statistical significance. Intensive care unit mortality was 30% in both groups. Simvastatin was well tolerated, with no increase in adverse events. Simvastatin decreased bronchoalveolar lavage IL-8 by 2.5-fold (P = 0.04). Plasma C-reactive protein decreased in both groups but failed to achieve significance in the placebo-treated group.Treatment with simvastatin appears to be safe and may be associated with an improvement in organ dysfunction in ALI. These clinical effects may be mediated by a reduction in pulmonary and systemic inflammation. Clinical trial registered with www.controlled-trials.com (ISRCTN70127774).
A note on the phase-plane technique representation of cardiac action potentials
Authors: E. L. DE BEER, H. B. K. BOOM, H. C. SCHAMHARDT
Journal: Cardiovascular Research (1976)

In this study the applicability of the phase-plane technique for interpreting membrane properties of cardiac cells in a two-dimensional structure is discussed. The conditions are derived for which the effects of two-dimensionality of a sheet.can be neglected and for which the one-dimensional phase-plane technique for estimation of the membrane current densities remains valid. The usual phase-plane technique appears to be applicable to nodal and atrial tissue.
433. Gene Therapy of Epilepsy by Adenovirus-Mediated Tetanus Toxin Light Chain Gene Transfer
Authors: Jun Yang, Qingshan Teng, Mary E. Garrity-Moses, Thais Federici, Imad Najm, Stephan Chabardes, Michael Moffitt, Nicholas M. Boulis
Journal: Molecular Therapy (2005)

Background: Focused inhibition of excitatory neurotransmission in the area of a seizure focus provides an ideal strategy to treat intractable neocortical epilepsy. Clostridial toxin light chain (LC) inhibits synaptic transmission by digesting vesicle-docking proteins without directly altering neuronal health. We have previously reported synaptic inhibition through adenoviral vector mediated LC expression (AdLC) in neural tissue. In the present experiment, we quantified the impact of cortical LC gene expression on focal seizures elicited in the rat.
Pathological Basis of Renal Disease
Authors: Stewart F. Cramer
Journal: JAMA (1977)

Dunnill's<i>Pathological Basis of Renal Disease</i>is more limited in scope than the title might suggest. Rather than a comprehensive inquiry into mechanisms of renal disease, it is a practical and cogent initiation into the complex realm of the modern clinical renal diagnostic unit. The author, a pathologist, coordinates clinical and morphological information with the experimental and empirical literature that forms the foundation of the modern approach to interpretation of renal biopsies. The reader is given more than just the requisite facts and figures. Dunnill also offers a cautiously reasoned and meticulously documented perspective. The text gives clear answers for clear-cut cases, and also gives the basis for making a rational judgment about cases that are less straightforward. The reader guided by this text will not find himself committed to a dogma of restricted vogue, but will find himself flexible, openminded, but critical in outlook, and prepared to assimilate new
Myocardial Function in Coronary Artery Disease Determined by Atrial Pacing
Authors: JOSEPH W. LINHART
Journal: Circulation (1971)

Right atrial pacing was performed in 21 patients with and 10 patients without coronary artery disease (CAD). The values for the control (C) and maximum paced (P) heart rate were similar in all patients. During pacing cardiac output did not change, and mean arterial pressure remained constant except for a slight increase during pacing-induced angina pectoris in 11 patients with CAD. Left ventricular end-diastolic pressure (LVEDP) decreased in the normal subjects (C=9 ± 1, P = 3 ± 1 sem mm Hg) and in all 10 patients with CAD who did not develop angina (C=5 ± 3, P = 5 ± 1 mm Hg). In 11 patients with CAD, developing angina, LVEDP did not decrease before pain occurred (C=9 ± 1, P = 9 ± 2 mm Hg) and increased during induced angina (P = 14 ± 3 mm Hg). Pacing ventricular function curves (VFC) relating induced changes in LVEDP and stroke work were abnormal in five of 10 patients with CAD and without induced angina when compared to the normal subjects. In patients developing angina, pacing VFC were normal in five of 10 before pain and then became abnormal in four of these five when angina occurred. Atrial pacing may be used to evaluate ventricular function and may demonstrate abnormalities in patients with CAD even in the absence of pacing-induced angina. Angina pectoris is usually associated with an overall decrease in myocardial function.
Peptic Ulcer in Glasgow
Authors: R. A. Jamieson, W. E. Smith, L. D. W. Scott
Journal: BMJ (1949)

From an analysis of reports from hospitals in Great Britain Nicol (1941) suggested that there is a geographical variation in the relative frequency of gastric and duodenal ulcer. Doubtless other geographical variations would come to light if sufficient information were available. Unfortunately the majority of hospital reports deal exclusively with in patients, and if the criteria for admission vary from one hospital to another the omission of out-patients may lead to serious error. So far the only complete survey of hos pital patients with peptic ulcer in this country was made in the Greater London area (Avery Jones and Pollak, 1945). We present for comparison the experience of a hospital in the West of Scotland.
Janeway lesions and Osier's nodes: A review of histopathologic findings
Authors: Alice C. Cardullo, David N. Silvers, Marc E. Grossman
Journal: Journal of the American Academy of Dermatology (1990)

The histologic findings in Osler's nodes and Janeway lesions have been reported rarely; we found descriptions of only 10 such cases, mostly from the late nineteenth- and twentieth-century French literature. We found gram-positive coccobacilli in the dermal abscess of a Janeway lesion from a patient with bacterial endocarditis. This finding suggests that septic microemboli are the cause.
Incidental Detection of Acute Lymphoblastic Leukemia on [<sup>18</sup>F]Fluorodeoxyglucose Positron Emission Tomography
Authors: Daisuke Ennishi, Yoshinobu Maeda, Masami Niiya, Katsuji Shinagawa, Mitsune Tanimoto
Journal: Journal of Clinical Oncology (2009)

A 32-year-old woman was referred to our hospital because of diffuse bone pain and a high fever lasting 2 weeks. She had a normal physical examination with no sign of hepatosplenomegaly or adenopathy. The hematological examination revealed no abnormalities; the WBC count was 7,410.0/mm (neutrophils, 84.9%; eosinophils, 0.8%; basophils, 0.4%; monocytes, 1.8%; lymphocytes, 12.2%), hemoglobin was 12.1 g/dL, and platelet count was 221,000/mm. Laboratory tests showed an increased lactate dehydrogenase (409 IU/L; reference range, 120 to 240 IU/L) and C-reactive protein (22.10 mg/dL; reference range, 0.00 to 0.30 mg/dL). Computed tomography (CT) and magnetic resonance imaging found no evidence of abnormalities, while positron emission tomography (PET)/CT with [F]fluorodeoxyglucose (FDG) showed diffuse increased bone marrow uptake (Fig 1). Based on the PET/CT result, we examined a bone marrow aspirate, which revealed 98% lymphoblasts (Fig 2). The leukemic cells in the bone marrow expressed CD19, CD10, CD34, and CD13 antigens. A multiplex real-time quantitative polymerase chain reaction assay showed that the copy number of minor BCR/ABL transcripts was elevated at 1.7 10 copies. She was diagnosed with acute lymphoblastic leukemia with the Philadelphia chromosome, was treated immediately with chemotherapy including imatinib, and achieved molecular complete remission. Routinely, PET/CT is used to find a wide variety of tumors with detection sensitivities and specificities usually exceeding 90%, particularly in cancers of the lung, colon, head and neck, and melanoma. In hematological malignancies, its value for diagnosis and response assessment has been confirmed in lymphoma, myeloid sarcoma, and multiple myeloma. Previous report assessed the response of acute myeloblastic leukemia using PET/CT with [F]fluorodeoxythymidine, although the diagnostic value of PET/CT has not been evaluated thoroughly in leukemia. In several published case reports, PET detected focal bone localization of leukemia, while bone marrow aspiration detected no abnormalities. In our case, leukemic cells were localized in the bone marrow only, while hematological examination of the peripheral blood revealed no abnormalities. PET/CT might be useful for detecting leukemia in cases that are difficult to diagnose, allowing treatment initiation without delay.
Site-directed mutagenesis of lysine within the immunodominant autoepitope of PDC-E2
Authors: Patrick S. C. Leung, Takashi Iwayama, Ross L. Coppel, Eric M. Gershwin
Journal: Hepatology (1990)

The major autoantigens of PBC have been identified as the four closely related mitochondrial enzymes PDC-E2, BCKD-E2 OGDC-E2 and protein X. A major structural similarity of these enzymes is the presence of one or more lipoyl domains. The immunodominant epitope of each autoantigen has either been postulated or been demonstrated to be located within the lipoate binding region. However, it is not clear whether the binding of lipoic acid to the epitope is necessary for autoantibody recognition. To address this issue we have constructed by oligonucleotide site-directed mutatagenesis three mutants in the lipoyl domain of human PDC-E2. Because lipoic acid is covalently bound to the ξ-amino group of the lysine residue of PDC-E2, the mutants were designed to replace the lysine residue in the lipoyl domain with glutamine, a negatively charged amino acid; histidine, a positively charged amino acid; and tyrosine, an aromatic amino acid. Binding reactivity of sera from patients with PBC were analyzed by enzyme-linked immunosorbent assay, immunoblotting and specific absorption against each of the three mutants and control clones. All data were compared with parallel studies with a control recombinant clone, the liver-specific F alloantigen. We believe the recognition of the lipoyl domain is a reflection of the surface-exposed, hydrophilic and relatively mobile nature of this region of the autoantigen. Further studies on direct assay for the presence of lipoic acid will be needed to clarify these issues. (HEPATOLOGY 1990;12:1321-1328).
SHORT-TERM AND LONG-TERM PROGNOSTIC VALUE OF THE TIMI RISK SCORE AFTER PRIMARY PERCUTANEOUS CORONARY INTERVENTION FOR ST-ELEVATION MYOCARDIAL INFARCTION
Authors: Peter Damman, Pier Woudstra, Jose PS Henriques, Marije M. Vis, Jan Baan, Karel T. Koch, Jan J. Piek, Jan GP Tijssen, Robbert J. de Winter
Journal: Journal of the American College of Cardiology (2011)
Abstract P6-05-06: Clinical Presentation of Molecular Apocrine Subgroup of Breast Cancer: A Rather Aggressive Group of Tumor
Authors: AS Hamy, S Leman, M Barritault, J Lehmann-Che, H Abuellelah, S Giacchetti, C Cuvier, A de Roquancourt, P Bertheau, H de The, M Marty, M. Espie
Journal: Cancer Research (2010)

Abstract Background: Estrogen receptor negative (ER-) breast cancer represents 30% of breast cancers. This heterogeneous group comprises at least the basal and HER2+ subgroups. Recent data, as well as our own, has observed that the HER2+ subtype is highly heterogeneous. Several teams have identified a new “apocrine” molecular subgroup of cancer, characterized by androgen receptor (AR) expresion in an ER-context. Here, we have retrospectively identified, based on a transcriptionnal signature, these apocrine molecular tumours and described their clinical presentation and evolution. Material and Methods: We retrospectively identified 60 patients treated in St Louis Hospital (Paris) from 1995 to 2008 and presenting the signature of the molecular apocrine subgroup (ERA-, AR+, FOXA1+) by Q-RT-PCR. Results: Mean age at diagnosis was 53,5 y.o. Tumours size were T2 or more in 78% cases. Histological types were ductal invasive with intraductal component (n=22), histological apocrine (n=3), and paget disease (n=4). Tumor grade was 3 in 68%, and 2 in 21%, with lymphovascular invasion in 37%. Excluding patients receiving neo-adjuvant chemotherapy, lymph node status was negative in 41%, and positive in 52% (1 to 3, 32%, more than 4N+, 20%). By immunohistochemistry 97.4% were PR-and 58.72% overexpressed HER2. Surgery was conservative in 46%, and 48% patients underwent mastectomy. Sixteen patients received neoadjuvant chemotherapy (27%), 41 received adjuvant chemotherapy (68%), 16 received hormonal therapy (27%), and 16 received trastuzumab (27%). With a median follow up of 60 months, 34 events (local recurrence n=9, contralateral n=3, distant metastasis n=22), and 13 deaths occurred. Median disease free survival was 48 months. Discussion: In this cohort of apocrine molecular carcinomas, tumor phenotypes appears to be rather aggressive, with a high proportion of poor prognosis factors (grade SBR3, lymphovascular invasion, node involvement), and are generally well-correlated to a poor clinical outcome in this population that received heterogeneous treatments. Further data are needed to precisely characterise this particular breast cancer subtype, notably patients who are not eligible to Herceptin-based regimen. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P6-05-06.
Self‐care management of heart failure: practical recommendations from the Patient Care Committee of the Heart Failure Association of the European Society of Cardiology
Authors: Mitja Lainscak, Lynda Blue, Andrew L. Clark, Ulf Dahlström, Kenneth Dickstein, Inger Ekman, Theresa McDonagh, John J. McMurray, Mary Ryder, Simon Stewart, Anna Strömberg, Tiny Jaarsma
Journal: European Journal of Heart Failure (2010)
US reports increase in liver cancer
Authors: S. Gottlieb
Journal: BMJ (1999)

The incidence of hepatocellular carcinoma is increasing in the United States, and the increase is expected to continue until the rate of the major cause—infection with hepatitis B or C—is brought under control.

The incidence of hepatocellular carcinoma increased by 71%from 1976 to 1995, according to figures published last …
Optimal frequency of carotid sinus nerve stimulation in treatment of angina pectoris
Authors: C. BORST, J. M. KAREMAKER, L. N. BOUMAN, A. J. DUNNING, F. J. G. SCHOPMAN
Journal: Cardiovascular Research (1974)

Carotid sinus nerve stimulation (CSNS) was applied in seven angina pectoris patients for periods of 1–2 min, using a modified Angistat (Medtronic) stimulator at frequencies ranging from 20 to 200 Hz. Stimulation at frequencies between 80 and 120 Hz elicited the largest increase in R-R interval and blood pressure reduction. Due to technical limitations of the device, the Angistat stimulator appears to be unsuitable if stimulation frequencies in excess of 120 Hz are to be applied. We conclude that the optimal frequency of the Angistat CSNS stimulator in the treatment of angina pectoris is between 80 and 120 Hz.
Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy
Authors: Anniek B. van der Waart, Noortje M. P. van de Weem, Frans Maas, Cynthia S. M. Kramer, Michel G. D. Kester, J. H. Frederik Falkenburg, Nicolaas Schaap, Joop H. Jansen, Robbert van der Voort, Luca Gattinoni, Willemijn Hobo, Harry Dolstra
Journal: Blood (2014)
Chronic pulmonary embolism in Klippel-Trenaunay syndrome
Authors: Renée A. Douma, Charlène E.U. Oduber, Victor E.A. Gerdes, Otto M. van Delden, Berthe L.F. van Eck-Smit, Joost C.M. Meijers, Eduard J. van Beers, Berto J. Bouma, Chantal M.A.M. van der Horst, Paul Bresser
Journal: Journal of the American Academy of Dermatology (2011)
Radiation Treatment in Older Patients: A Framework for Clinical Decision Making
Authors: Grace L. Smith, Benjamin D. Smith
Journal: Journal of Clinical Oncology (2014)

In older patients, radiation treatment plays a vital role in curative and palliative cancer therapy. Radiation treatment recommendations should be informed by a comprehensive, personalized risk-benefit assessment that evaluates treatment efficacy and toxicity. We review several clinical factors that distinctly affect efficacy and toxicity of radiation treatment in older patients. First, locoregional tumor behavior may be more indolent in older patients for some disease sites but more aggressive for other sites. Assessment of expected locoregional relapse risk informs the magnitude and timeframe of expected radiation treatment benefits. Second, assessment of the competing cancer versus noncancer mortality and morbidity risks contextualizes cancer treatment priorities holistically within patients' entire spectrum and time course of health needs. Third, assessment of functional reserve helps predict patients' acute treatment tolerance, differentiating those patients who are unlikely to benefit from treatment or who are at high risk for treatment complications. Potential radiation treatment options include immediate curative treatment, delayed curative treatment, and no treatment, with additional consideration given to altered radiation target, dose, or sequencing with chemotherapy and/or surgery. Finally, when cure is not feasible, palliative radiation therapy remains valuable for managing symptoms and achieving meaningful quality-of-life improvements. Our proposed decision-making framework integrates these factors to help radiation oncologists formulate strategic treatment recommendations within a multidisciplinary context. Future research is still needed to identify how advanced technologies can be judiciously applied in curative and palliative settings to enhance risk-benefit profiles of radiation treatment in older patients and more accurately quantify treatment efficacy in this group.
Atlantoaxial subluxation and spinal cord compression in psoriatic arthropathy.
Authors: S S Santavirta, Y T Konttinen
Journal: Annals of the Rheumatic Diseases (1988)

Acute and chronic stress differentially regulate immediate-early gene (IEG) expression in the brain. Although acute stress induces c-Fos and FosB, repeated exposure to stress desensitizes the c-Fos response, but FosB-like immunoreactivity remains high. Several other treatments differentially regulate IEG expression in a similar manner after acute versus chronic exposure. The form of FosB that persists after these chronic treatments has been identified as ΔFosB, a splice variant of the <i>fosB</i> gene. This study was designed to determine whether the FosB form induced after chronic stress is also ΔFosB and to map the brain regions and identify the cell populations that exhibit this effect. Western blotting, using an antibody that recognizes all Fos family members, revealed that acute restraint stress caused robust induction of c-Fos and full-length FosB, as well as a small induction of ΔFosB, in the frontal cortex (fCTX) and nucleus accumbens (NAc). The induction of c-Fos (and to some extent full-length FosB) was desensitized after 10 d of restraint stress, at which point levels of ΔFosB were high. A similar pattern was observed after chronic unpredictable stress. By use of immunohistochemistry, we found that chronic restraint stress induced ΔFosB expression predominantly in the fCTX, NAc, and basolateral amygdala, with lower levels of induction seen elsewhere. These findings establish that chronic stress induces ΔFosB in several discrete regions of the brain. Such induction could contribute to the long-term effects of stress on the brain.
Abstract C33: Integrated analysis of sequence variations and copy number in TCGA colon adenocarcinoma data
Authors: Andrea O'Hara, Raja Keshavan, Louis Culot, Soheil Shams
Journal: Cancer Research (2013)

Abstract The Cancer Genome Atlas (TCGA) data is available via the TCGA portal and includes copy number data and whole exome sequencing data. Nexus Copy Number 7 was used to evaluate level-1 approved SNP array data from the colon adenocarcinoma (COAD) data set. All samples were subjected to match-paired analysis to evaluate somatic copy number variation. Samples were subjected to extensive pre-processing, including systematic G/C wave correction, ploidy correction, gender correction and quality control. Corresponding level-3 somatic mutation data was used for an integrated analysis of copy number and sequence variation with the COAD data set. Comprehensive copy number analysis identified frequent (&amp;gt;35%) copy number gains of chr7, chr8q, chr13 and chr20, and losses of chr8p, chr17p, and chr18. GISTIC analysis further identified statistically significant focal changes which included loss of FHIT on chr3. Genes KRAS and BRAF were among the most frequently mutated genes. Integrated analysis identified several regions of copy number change that significantly co-occurred with BRAF mutation. Copy number profiles varied significantly between hypermutable and non-hypermutable samples. Potential chromothriptic events were also observed within the COAD dataset. An approach that can integrate structural and sequence variation among samples will be presented. Citation Format: Andrea O'Hara, Raja Keshavan, Louis Culot, Soheil Shams. Integrated analysis of sequence variations and copy number in TCGA colon adenocarcinoma data. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr C33.