tbuckley/cabot-search huggingface dataset:
A Comparison of lndium-111 Leukocyte and Gallium-67 Scintigraphy in a Patient With a Myocardial Abscess
Authors: JOEL M. ROSEN, SUMATHI MURTHY, DANIEL R. HAIN
Journal: Clinical Nuclear Medicine (1993)

A myocardial abscess, which developed in a 59-year-old man 3 years following aortic valve replacement, was detected by ln-111 leukocyte scintigraphy but not by Ga-67 scintigraphy. Although both ln-111 leukocyte scintigraphy and Ga-67 scintigraphy have been reported to detect myocardial abscesses, a comparison of the two studies in the same patient has not been reported previously. In this patient, only the scan performed with ln-111 leukocytes demonstrated significant localization of radiotracer in the abscess.
Assessment of iron stores in children with transfusion siderosis by biomagnetic liver susceptometry
Authors: Roland Fischer, Christian D. Tiemann, Rainer Engelhardt, Peter Nielsen, Matthias D�rken, Erich E. Gabbe, Gritta E. Janka
Journal: American Journal of Hematology (1999)

To investigate the applicability of noninvasive Superconducting Quantum Interference Device (SQUID) biomagnetic liver susceptometry and its limitations in thalassemic children, 23 patients with β-thalassemia major and other iron loading anemias (age: 4–16 years) and 16 age-related normal children were studied. Liver iron concentrations ranged from 600 to 11,000 μg/gliver for thalassemic patients and from 60 to 340 μg/gliver for normal patients. Measuring the respective organ volumes by sonography, liver and spleen iron stores, accounting for 80% of total body iron stores, were estimated. Nonliver contributions from the lung or intestine to the measured SQUID signals in the small-sized patients were not observed. Moreover, livers in thalassemia were found to be enlarged by 18% per 1,000 μg/g (r = 0.75, P < 10−3). Serum ferritin values correlate significantly with iron stores (r = 0.64, P < 10−3), but predict iron stores only within large error intervals of 4,000 μg/gliver. Analyzing the experimental data from biomagnetometry and from related transfusion and chelation treatment data within the framework of a two-compartment model, we were able to derive additional information on total body iron elimination and chelation therapy efficacy. The exponential decline of iron stores allows forecast of steady-state conditions of the final iron load for a particular transfusion and chelation therapy regimen. Am. J. Hematol. 60:289–299, 1999. © 1999 Wiley-Liss, Inc.
Effect of high degree of hypertrophy on left ventricular diastolic function in patients with hypertrophic cardiomyopathy
Authors: Quirino Ciampi, Sandro Betocchi, Maria A. Losi, Raffaella Lombardi, Carlo G. Tocchetti, Elpidio Pezzella, Filippo Finizio, Mariano Aversa, Marianna Miranda, Massimo Chiariello
Journal: Journal of the American College of Cardiology (2002)
Clinton brokers deal to lower price of antiretrovirals
Authors: Seye Abimbola
Journal: BMJ (2007)

An influential group of MPs has claimed that widespread financial incompetence is adding to the cost of the United Kingdom's controversial private finance initiative (PFI).The House of Commons Committee of Public Accounts made its new attack on the PFI after it discovered that the government had clawed back £100m (€145m; $200m) less than was predicted from the new private-public profit sharing schemes.The committee's chairman, the Conservative MP Edward Leigh, blamed the loss on the failure of Treasury officials to oversee key refinancing arrangements.In 2002 ministers introduced changes so that public sector bodies could share in some of the financial gains when big PFI loans were rearranged.Typically, these loans were renegotiated on a more favourable basis once PFI projects had been completed and the risks involved were lower.However, left to their own devices, officials in local hospitals had been out of their depth negotiating with their counterparts in the private sector, the committee says.In 2003 the Office of Government Commerce, which then had responsibility for PFI policy, told the public accounts committee that it expected the public sector to receive between £175m and £200m from the voluntary sharing arrangements in early PFI deals.However, up to December 2006 the government had secured the right to gains of only £93m."Proceeds gained by the public sector from PFI debt refinancing under the voluntary code for the sharing of gains are currently well short of expectations" said Mr Leigh.
Visual Cycle Impairment in Cellular Retinaldehyde Binding Protein (CRALBP) Knockout Mice Results in Delayed Dark Adaptation
Authors: John C. Saari, Maria Nawrot, Breandan N. Kennedy, Gregory G. Garwin, James B. Hurley, Jing Huang, Daniel E. Possin, John W. Crabb
Journal: Neuron (2001)
Intense Bilateral Pectoralis Major Muscle Activity on Tc-99m MDP Scintigraphy: The Push-up Sign
Authors: Gavin C. Mackie, Ben A. Dwamena, Milton D. Gross, Lorraine M. Fig
Journal: Clinical Nuclear Medicine (2004)

Uptake of Tc-99m MDP by skeletal muscle may occur after strenuous physical activity and is usually an incidental finding. The case of a 37-year-old man who underwent bone scintigraphy for the evaluation of back pain is presented. Although no cause for the back pain was found, delayed imaging demonstrated bilateral symmetric Tc-99m MDP activity in the pectoral muscles. The patient gave a history of performing upper torso exercises 48 hours before the examination, but had no symptoms referable to the pectoral muscles.
Ultrasound in diagnosing hydrocephalus.
Authors: M F Reed
Journal: BMJ (1972)

Vaccination 5 4 4 0c2 °2 ----Treatment O 2 3 4 Time (weeks)cantly (t = 4. 185, P < 0001) lower than in controls.The finding that co-trimoxazole in dosages commonly used for curing bacterial in- fections in man partially suppresses antibody response warrants more detailed investiga- tion.Whether the effect is due to the com- bined drug or trimethoprim alone also remains to be investigated.-Weare, etc.,
In Defense of the Duty to Participate in Biomedical Research
Authors: Rosamond Rhodes
Journal: The American Journal of Bioethics (2008)

"In Defense of the Duty to Participate in Biomedical Research." The American Journal of Bioethics, 8(10), pp. 37–38 This commentary draws on my remarks at the (APA), Pacific Division meeting, Pasadena, CA (March 20, 2008), where I presented comments on an article by Inmaculada de Melo-Martin: "A response to De Melo-Martin on a duty to participate in research."
Pediatric Anesthesia: A Guide to Its Administration
Authors: Maxine T. Clarke
Journal: JAMA (1981)

This succinct guide to pediatric anesthesia, by a distinguished clinician in the field, is suitable for quick reference and case planning. The author's approach is pragmatic and methodical, with setups and sequences reinforced by tables, diagrams, and photographs. The textual material suffers from an apparent lack of editing, there being a number of grammatical and spelling errors. References for further study are included in three of the 29 chapters, a regrettably small proportion. Dr Mayer's text amply reflects his expertise, experience, and wisdom. Only in his recommendation for the use of succinylcholine chloride as an aid to intubation in acute epiglottitis did this reviewer note a surprising inconsistency with usual anesthetic teaching. His ability to select only the most essential features of a complex problem is particularly well illustrated in his concise chapter on resuscitation.
136 ENDOGLIN DEFICIENCY IN HEPATIC STELLATE CELLS HAS A DIFFERENTIAL EFFECT ON LIVER FIBROSIS AND TGF-b SIGNALLING IN TWO EXPERIMENTAL MODELS OF MURINE LIVER FIBROSIS
Authors: M. Alsamman, R. Weiskirchen, H. Wasmuth, D. Brenner, C. Trautwein, D. Scholten
Journal: Journal of Hepatology (2013)
Combined effect of cigarette smoke and mineral fibers on the gene expression of cytokine mRNA.
Authors: Y Morimoto, T Tsuda, H Hori, H Yamato, A Ohgami, T Higashi, N Nagata, M Kido, I Tanaka
Journal: Environmental Health Perspectives (1999)

To investigate which parameters are stimulated by mineral fibers and whether cigarette smoke enhanced a fiber-induced response, we examined the level of cytokine mRNA from alveolar macrophages (AMs) and lungs of rats exposed to mineral fibers and cigarette smoke in vivo. Male Wistar rats were given a single intratracheal instillation of 2 mg of Union Internationale Contre le Cancer chrysotile or refractory ceramic fiber (RF1). The animals then inhaled a side stream of smoke 5 days per week for 4 weeks. The expression of manganese superoxide dismutase, inducible nitric oxide synthase (iNOS), basic fibroblast growth factor (bFGF), interleukin-1[alpha] (IL-1[alpha]), interleukin-6 (IL-6), and tumor necrosis factor-[alpha] (TNF[alpha]) mRNA from lipopolysaccharide-stimulated AMs and lungs of rats exposed to mineral fibers and/or cigarette smoke were assessed using semiquantitative reverse-transcriptase polymerase chain reaction. Exposure only to cigarette smoke increased in IL-1[alpha] mRNA levels in AMs. Chrysotile stimulated the expression of IL-1[alpha], TNF[alpha], and IL-6 in AMs, and the expression of bFGF in lungs. RF1 resulted in increased expression of IL-1[alpha] and TNF[alpha] in AMs. Cigarette smoke stimulated the gene expression of iNOS in AMs and IL-6 and bFGF in lungs treated with chrysotile; IL-1[alpha] in AMs and bFGF in lungs did the same in lungs with RF1. Among these cytokines, message levels of IL-1[alpha], iNOS, and bFGF were increased in rats stimulated with mineral fibers, and the stimulating effects of mineral fibers were enhanced by cigarette smoke. Therefore, IL-1[alpha], iNOS, and bFGF would be the possible parameters of the lung remodeling induced by mineral fibers.
Value of Re-examining X-ray Films of Outpatients Attending Accident Services
Authors: C. S. B. Galasko, P. R. W. Monahan
Journal: BMJ (1971)

X-ray films of 4,665 patients who had attended an accident service as outpatients were reviewed by the clinicians and reported on by the radiologist the next day.In 20 cases the radiologist did not comment on bony injuries which had been diagnosed and treated by the accident service senior house officer. The radiologist, however, detected bony injuries which had been missed by the accident service senior house officer in 26 cases. In 10 cases injuries which had not been detected at the original examination or by the radiologist were noted when the x-ray films were reviewed. On two occasions the fracture was missed at all three examinations.The daily joint review of x-ray films by accident service officers and the radiologist seemed to increase the clinical and radiological acumen of the staff of the accident service.
620 IDENTIFYING PATIENTS WITH A HIGH LIKELIHOOD OF ACHIEVING AN SVR FOLLOWING RE-TREATMENT WITH PEGINTERFERON ALFA-2A (40KD) PLUS RIBAVIRIN: USE OF POSITIVE PROGNOSTIC FACTORS (PPF'S)
Authors: D.M. Jensen, A. Craxi, C.E. Brandão-Mello, A.M. Di Bisceglie, P. Andreone, B. Freilich, K.R. Reddy, A. Oliveira Martin, G. Teuber, D. Messinger, J.A. Thommes, A. Tietz, P. Marcellin
Journal: Journal of Hepatology (2009)
Muco‐ciliary differentiation of nasal epithelial cells is decreased after wound healing <i>in vitro</i>
Authors: D. S. Lazard, A. Moore, V. Hupertan, C. Martin, V. Escabasse, P. Dreyfus, P.‐R. Burgel, S. Amselem, E. Escudier, A. Coste
Journal: Allergy (2009)

Epithelial damage and modifications of cell differentiation are frequent in airway diseases with chronic inflammation, in which transforming growth factor-beta1 (TGF-beta1) plays an important role. The aim of this study was to evaluate the differentiation of human nasal epithelial cells (HNEC) after wound healing and the potential effects of TGF-beta1.Basal, mucus, and ciliated cells were characterized by cytokeratin-14, MUC5AC, and betaIV tubulin immunodetection, respectively. Their expression was evaluated in situ in nasal polyps and in an in vitro model of wound healing in primary cultures of HNEC after wound closure, under basal conditions and after TGF-beta1 supplementation. Using RT-PCR, the effects of TGF-beta1 on MUC5AC and DNAI1 genes, specifically transcribed in mucus and ciliated cells, were evaluated.In situ, high TGF-beta1 expression was associated with low MUC5AC and betaIV tubulin expression. In vitro, under basal conditions, MUC5AC expression remained stable, cytokeratin-14 expression was strong and decreased with time, while betaIV tubulin expression increased. Transforming growth factor-beta1 supplementation downregulated MUC5AC and betaIV tubulin expression as well as MUC5AC and DNAI1 transcripts.After a wound, differentiation into mucus and ciliated cells was possible and partially inhibited in vitro by TGF-beta1, a cytokine that may be involved in epithelial remodeling observed in chronic airway diseases.
A COMPARISON OF SODIUM AMYTAL AND PERNOCTON AS PRE-ANAESTHETIC HYPNOTICS
Authors: E. I. McKesson, K. C. McCarthy
Journal: BMJ (1930)

P O 'MEDICAL JOURNA__ I consid(ler that the initravenous metlhod r-equiires some experience aiid techlnical skill, and that thje patients receiving suchl injections should be under close ilnstitutional super-Vision.As is wvell known, no fixed rule can be used for calculating the dosage, and individual variations exist in mali.This one poinit alone is sufficient to contraindicate the usse of barbituric acid delrivatives in large doses.It is considlered, lhowever, that doses of 3 to 9 grailns (0.2 to 0.6 giraiii), nlot excee(ling 15 grlaiIns (1 gram), are comeparatively safe limllits for so(lium amliytal.It is seldom necessary to use more tlhani 7a to 9 grainls (0.5 to 0.6 guam).In the field of aniaestihesia tllere is am-riple evidence that so(lium amytal is useful primar ily as a: lhypnlotic for the pre-anaesthetic lreeparation of the patient, and not as an anaesthetic agent.In the field of medicine it is useful for the contr-ol of convulsions, unmnanag,able miiental cases, and as a specific for strychnine poisoning.
The Angelchik Antireflux Prosthesis
Authors: Jean P. Angelchik
Journal: JAMA (1987)

<h3>To the Editor.—</h3> It is my understanding that, of the 24 DATTA panelists who assessed the Angelchik antireflux prosthesis,<sup>1</sup>few were surgeons and of these even fewer had ever implanted this antireflux device. Eight of the panelists found the device unacceptable. The conclusions of this well-re-searched article are not supported by the data presented therein. It is my belief that if you take the other major procedures for antireflux surgery—like Nissen's fundoplication, Hill's procedure, or the Belsey operation—and present them to a panel of 24 surgeons, one third will probably find any one of these procedures unacceptable simply because these surgeons employ one of the other procedures and find it satisfactory. In the case of 24 physicians who are not specialist surgeons, I cannot begin to imagine what the conclusions would be. The article mentions that of the 7721 protheses with vulcanized straps that were used from 1979 through
A Human Severe Combined Immunodeficiency (SCID) Condition with Increased Sensitivity to Ionizing Radiations and Impaired V(D)J Rearrangements Defines a New DNA Recombination/Repair Deficiency
Authors: Nathalie Nicolas, Despina Moshous, Marina Cavazzana-Calvo, Dora Papadopoulo, Régina de Chasseval, Françoise Le Deist, Alain Fischer, Jean-Pierre de Villartay
Journal: The Journal of Experimental Medicine (1998)

The products of recombination activating gene (RAG)1 and RAG2 initiate the lymphoid-specific phase of the V(D)J recombination by creating a DNA double-strand break (dsb), leaving hairpin-sealed coding ends. The next step uses the general DNA repair machinery of the cells to resolve this dsb. Several genes involved in both V(D)J recombination and DNA repair have been identified through the analysis of in vitro mutants (Chinese hamster ovary cells) and in vivo situations of murine and equine severe combined immunodeficiency (scid). These studies lead to the description of the Ku–DNA-dependent protein kinase complex and the XRCC4 factor. A human SCID condition is characterized by an absence of B and T lymphocytes. One subset of these patients also demonstrates an increased sensitivity to the ionizing radiation of their fibroblasts and bone marrow precursor cells. This phenotype is accompanied by a profound defect in V(D)J recombination with a lack of coding joint formation, whereas signal joints are normal. Functional and genetic analyses distinguish these patients from the other recombination/repair mutants, and thus define a new group of mutants whose affected gene(s) is involved in sensitivity to ionizing radiation and V(D)J recombination.
Decay-accelerating factor is expressed on vascular smooth muscle cells in human atherosclerotic lesions.
Authors: P S Seifert, G K Hansson
Journal: Journal of Clinical Investigation (1989)

Decay-accelerating factor (DAF) is a constitutively expressed plasma membrane glycoprotein on blood cells and endothelium that inhibits cell surface C3/C5 convertase formation, thus inhibiting complement activation and protecting cells from lysis by the terminal complement components. Using monoclonal anti-DAF antibodies in conjunction with anti-smooth muscle cell (SMC)-specific myosin antibodies, it was found by immunohistochemistry that vascular SMC in advanced human carotid atherosclerotic lesions express DAF antigen. The percentage of DAF-positive SMC ranged from 20 to 60% between different patient samples and SMC DAF expression was limited to SMC in the lesion proper. Normal arterial wall SMC exhibited no DAF-specific immunostaining. Essentially 100% of passaged cultured vascular SMC derived from normal human uterine artery, or from umbilical vein, expressed DAF as assessed by immunocytochemistry. A 68-kD band was observed on SDS-PAGE autoradiograms of DAF-immunoprecipitated radiolabeled cultured SMC extracts. Sensitization of rabbit erythrocytes with DAF-containing SMC extracts conferred protection against complement-mediated hemolysis in normal human serum and the protective effect could be reversed by treatment with anti-DAF antibodies. We conclude that DAF is induced on vascular SMC during atherogenesis and in culture.
New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma
Authors: Zorica Scuric, Steven C. Stain, French W. Anderson, Jung-Joo Hwang
Journal: Hepatology (1998)

The multistep process of liver carcinogenesis involves various genetic and phenotypic alterations. To identify genes whose expression is increased during hepatocarcinogenesis, differential-display polymerase chain reaction (DD-PCR) was used to examine differences in the mRNA composition of hepatocellular carcinoma (HCC) versus normal liver (nontumor) tissues. This approach identified 67 cDNAs that were preferentially expressed in HCC tissue. When these cDNAs were analyzed by reverse-Northern analysis, five were reproducibly expressed at high levels in HCC. Interestingly, Northern blot analysis revealed that one of the genes showed significantly increased mRNA levels in all five tested tumor samples, while its mRNA level in the nontumor samples was minimal. BLAST analysis revealed that this gene has high sequence identity with the genes from aldo-keto reductase family of proteins including the mouse fibroblast growth factor-induced gene (FR-1) (80% identity), mouse vas deferens protein (MVDP) (76%), and human aldose reductase (AR) (62%). Expression of this novel AR-related protein in all five tested HCCs suggests that this protein may play an important role in liver carcinogenesis.
MyD88 Signaling Controls Autoimmune Myocarditis Induction
Authors: René R. Marty, Stephan Dirnhofer, Nora Mauermann, Sacha Schweikert, Shizuo Akira, Lukas Hunziker, Josef M. Penninger, Urs Eriksson
Journal: Circulation (2006)

Experimental autoimmune myocarditis (EAM) is a CD4+ T-cell-mediated mouse model of postviral cardiomyopathy. Activation of interleukin-1 type 1 and Toll-like receptors that share the common downstream adaptor molecule MyD88 is required for disease induction. The specific role of MyD88 in myocarditis, however, is not known.In contrast to control littermates, MyD88(-/-) mice were protected from myocarditis after immunization with alpha-myosin heavy chain-derived peptide (MyHC-alpha) and complete Freund's adjuvant. Disease resistance of MyD88(-/-) mice resulted from impaired expansion of heart-specific CD4+ T cells after immunization. Intrinsic defects of MyD88(-/-) CD4+ T cells were excluded. In contrast, MyD88(-/-) but not MyD88(+/+) primary antigen presenting dendritic cells (DCs) were defective in their capacity to prime CD4+ T cells. This defect mainly resulted from the inability of MyD88(-/-) DCs to release tumor necrosis factor-alpha. The critical role of MyD88 signaling in DCs in the peripheral lymphatic compartments was finally proven by repetitive injection of activated, MyHC-alpha-loaded MyD88(+/+) DCs that fully restored T-cell expansion and myocarditis in MyD88(-/-) mice.Autoimmune myocarditis induction depends on MyD88 signaling in self-antigen presenting cells in the peripheral compartments. We conclude that MyD88 might become a target for prevention of heart-specific autoimmunity and cardiomyopathy.
Reply from Authors re: Antonella Giannantoni. Patient-Reported Outcomes in Bladder Pain Syndrome: Qui Auget Dolorem, Auget et Scientiam (As Pain Increases, So Increases Knowledge). Eur Urol 2012;61:280–1
Authors: Louise Humphrey, Rob Arbuckle, Rob Moldwin, Jorgen Nordling, Joop P. van de Merwe, Juliette Meunier, Tim Crook, Lucy Abraham
Journal: European Urology (2011)
Transmission of human immunodeficiency virus to sexual partners of hemophiliacs
Authors: M. Lynn Smiley, Gilbert C. White, Paul Becherer, Gail Macik, Thomas J. Matthews, Kent J. Weinhold, Campbell McMillan, Dani Bolognesi
Journal: American Journal of Hematology (1988)

To examine the variables associated with heterosexual transmission of human immunodeficiency virus (HIV), we studied 32 couples in our hemophilia center who had steady sexual relationships for periods more than 1 year. Of the 32 sexual partners of the hemophiliacs, five (15.6%) were HIV seropositive. All five hemophiliacs with HIV transmission to their sexual partners had measurable immunologic deficiencies, as shown by their lower median T-helper (CD-4+) lymphocyte count of 172 cells/mm3. The hemophiliacs without transmission had a slightly higher median CD-4+ count of 297 cells/mm3 (P = .26). To determine if factors other than the degree of immunologic deficiency in the hemophiliac might contribute to HIV transmission, 18 of the 32 couples were studied more intensively by confidential, coded questionnaires. Regular condom use was reported by nine couples (50%). Two of nine women (22%) without condom usage acquired HIV. One of nine women (11%) using condoms was seropositive; she also reported eight needlestick injuries while assisting her spouse with clotting factor treatments. Intravenous drug abuse was reported in two of the five couples with HIV transmission. Thus, hemophiliacs are at risk for transmitting HIV parenterally as well as venereally. Despite various risk behaviours associated with HIV transmission, the prevalence of infection in our cohort of hemophiliacs' sexual partners is low and within the range (6.8-22%) reported by others. This study underscores the need for comprehensive education and counseling in what previously appeared to be a homogeneous clinic population at risk for transmitting HIV to others.