tbuckley/cabot-search huggingface dataset:
Assembly of the prothrombin activator complex on rabbit alveolar macrophage high-affinity factor Xa receptors. A kinetic study.
Authors: M P McGee, H Rothberger
Journal: The Journal of Experimental Medicine (1986)

Efficient prothrombin activation occurs after assembly of factors Va, Xa, and phospholipid surface cofactor as a multimolecular complex. These components are provided by platelets and plasma within the vascular space, but molecules and membranes for prothrombin activator assembly in extravascular spaces have not been identified. In the present study, purified alveolar macrophages were found to produce high-affinity factor Xa receptors that mediate formation of enzymatic prothrombinase complexes and rapid prothrombin to thrombin conversion in the absence of exogenous factor V/Va or platelets. Thus, in reaction mixtures with alveolar macrophages cultured for 20 h in serum-free medium, the thrombin formation rate was 152 nM/min/0.66 X 10(6) cells, after adding prothrombin (1.5 microM), Ca2+ (5 mM), and factor Xa (3.7 nM). The observed Kd of factor Xa interaction with macrophage receptors is 2.1 +/- 0.94 X 10(-10) M. Kinetic analysis and inhibition studies using isolated factor V and anti-factor V antibody show that macrophage Xa receptors are functionally and antigenically similar to plasma factor V. By contrast, freshly isolated cells lacked receptors promoting prothrombin conversion at high rates. Inhibitors of protein synthesis and glycosylation, puromycin and monensin, respectively, abrogated production of Xa receptors in culture. Additionally, subcellular fractionation and enzyme-marker studies (alkaline phosphodiesterase I) indicate that internal and external membranes of alveolar macrophages have phospholipid surface cofactor activity required for prothrombinase complexes. Pulmonary surfactant is also shown to express this cofactor activity. Alveolar macrophages and surfactant comprise an efficient prothrombin activator system that is independent of plasma factor V. This system may facilitate rapid extravascular alveolar thrombin formation even at very low concentrations of factor Xa during lung defense reactions to inflammation or edema.
Obstructive Lung Disease and Altitude Adaptation
Authors: William R. Barclay
Journal: JAMA (1978)

Patients suffering from chronic obstructive lung disease frequently inquire of their physicians whether they can safely travel in commercial aircraft and vacation or even stay for a prolonged period at a higher altitude. The answer to such a question depends on many factors in addition to the degree of lung impairment, but there are relatively few studies to guide a physician in the assessment of altitude's effects on the mechanics of breathing and blood gas values. Graham and Houston (p 1491) have performed a valuable service by making a study of patients with mild and moderately severe chronic obstructive lung disease at sea level and then at an altitude of 1,920 m (6,300 ft). The purpose of their study is a departure from the usual, for most investigations focus on the epidemiology, pathology, or course of a disease. This study addresses the important topic of response to a disease in
Comparison of the BTA &lt;i&gt;stat&lt;/i&gt;&lt;sup&gt;TM&lt;/sup&gt; Test with Voided Urine Cytology and Bladder Wash Cytology in the Diagnosis and Monitoring of Bladder Cancer
Authors: Herbert Leyh, Michael Marberger, Pierre Conort, Cora Sternberg, Vito Pansadoro, Francesco Pagano, Pierfrancesco Bassi, Laurent Boccon-Gibod, Vincent Ravery, Uwe Treiber, Laura Ishak
Journal: European Urology (1999)
Microvascular Obstruction After Radiofrequency Ablation of Ventricular Tachycardia
Authors: Jordi Estornell-Erill, Francisco Ridocci-Soriano, Aurelio Quesada-Dorador, Pau Federico-Zaragozá, Oscar Fabregat-Andrés, Victor Palanca-Gil, Javier Jimenez-Bello
Journal: Journal of the American College of Cardiology (2010)
UMBILICAL DISPLACEMENT AND DEVIATION OF LINEA ALBA IN ACUTE ABDOMINAL CONDITIONS
Authors: F. CO TUI
Journal: JAMA (1928)

Oppenheim 1 described a dislocation of the umbilicus toward the sound side in unilateral paralysis of the abdominal wall (the mechanism is presumably similar to the drawing of the mouth toward the sound side in facial paralysis). Schlesinger, 2 in 1921, described a sign which he called die Nabelverziehung, occurring in certain cases of prepyloric ulcers and acute cholecystic disease. This is a transient displacement of the umbilicus toward the affected side when the patient is made to press downward as at stool, with a return to its normal position in a few seconds.  We have encountered a physical condition that bears some resemblance to both Oppenheim's and Schlesinger's sign. It is a prolonged displacement of the linea alba and the umbilicus to the affected side with skin surface disturbances in the form of folds and creases on the side to which the linea alba and the navel are drawn.
The scourge of ulcers
Authors: T. Dalrymple
Journal: BMJ (2012)

<h3>Abstract</h3> Pathogenic bacteria and viruses in medical environments can lead to treatment complications and hospital-acquired infections (HAIs), and current cleaning protocols do not address hard-to-access areas or that may be beyond line-of-sight treatment such as with ultraviolet radiation. At the time of writing, the ongoing pandemic of the novel coronavirus known as novel coronavirus (2019-nCoV) has claimed over 4 million cases worldwide and is expected to have multiple peaks, with possible resurgences throughout 2020. It is therefore imperative that disinfection methods in the meantime be employed to keep up with the supply of personal protective equipment (PPE) and sterilize a wide array of surfaces as quarantine lockdowns begin to be lifted. Here, we tested the efficacy of Sani Sport ozone devices as a means to treat hospital equipment and surfaces for killing bacteria, degrading synthetic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA, and RNA from non-replicative capsid enclosed SARS-CoV-2. We observed a rapid killing of medically-relevant and environmental bacteria (<i>Escherichia coli</i>, <i>Enterococcus faecalis</i>, <i>Bacillus subtlis</i>, and <i>Deinococcus radiodurans</i>) across four surfaces (blankets, catheter, remotes, and syringes) within 30 minutes, and up to a 99% reduction in viable bacteria at the end of 2-hour treatment cycles. Significant RNA degradation of synthetic SARS-CoV-2 RNA was seen an hour into the ozone treatment as compared to non-treated controls and a non-replicative form of the virus was shown to have significant RNA degradation at 30 minutes compared to a no treatment control and RNA degradation could be reliably detected at 10,000 and 1,000 copies of virus per sample. These results show the strong promise of ozone treatment for reducing risk of infection and HAIs.
Variants in the gene encoding acyloxyloacyl hydroxylase (AOAH) are associated with total IgE (tIgE)*1
Authors: D. Baltadzhieva, T. Berg, A. Zambelli-Weiner, R.A. Mathias, O. Zardkoohi, M. Brummet, L.A. Beck, K. Barnes
Journal: Journal of Allergy and Clinical Immunology (2004)
New insights into the phylogeny of eukaryotes based on ciliate Hsp70 sequences
Authors: K. Budin, H. Philippe
Journal: Molecular Biology and Evolution (1998)

The current framework of the eukaryotic phylogeny is based on the analysis of a comprehensive set of sequences of the small subunit ribosomal RNA. However, phylogenies based on protein-encoding genes are not completely congruent with this picture. Since congruence between different markers is the best tool to determine evolutionary history, we focused on Hsp70 (heat-shock protein of 70 kDa), a chaperone protein which is highly conserved and is a potentially reliable phylogenetic marker. We used a PCR-based approach to sequence Hsp70s in two distinct classes of Ciliates. Seven Hsp70s were identified from Paramecium tetraurelia (Oligohymenophora) and six Hsp70s from Euplotes aediculatus (Hypotricha), encompassing orthologous genes for all major Hsp70 classes of Eukaryotes, i.e., those localized in cytosol, in endoplasmic reticulum, and in mitochondria. Three independent phylogenies of eukaryotes, based on each set of orthologous genes, have been constructed using different tree reconstruction methods. A significant advantage of Hsp70s is the existence of outgroups close to Eukaryotes for these major classes, reducing the long-branch attraction artifact due to the outgroup. The monophyly of Ciliates is supported by good bootstrap proportions in the phylogenetic reconstructions, and this phylum is generally a sister-group of Sporozoa, forming the expected Alveolates clade. The Hsp70 seems to be a suitable phylogenetic marker since it recovers all the monophyletic groups, undoubtedly defined by morphological criteria. The Hsp70 trees are, however, notably different from the rRNA ones and do not show two aspects of the classical topology, i.e., the successive emergence of deeply branching groups and the vast assembly of the major eukaryotic groups, emerging at the tip of the tree, i.e., the "terminal crown". More precisely, the Hsp70 trees do not resolve the relationships between the major groups of Eukaryotes with confidence, in keeping with the hypothesis that all these groups emerged in a great radiation that occurred at the origin of all the extant Eukaryotes.
Assessing the Safety of Adding LABAs to Inhaled Corticosteroids for Treating Asthma
Authors: Badrul A. Chowdhury, Sally M. Seymour, Mark S. Levenson
Journal: New England Journal of Medicine (2011)

The FDA has issued a requirement for manufacturers of long-acting beta-agonists (LABAs) marketed for asthma to conduct controlled clinical trials to assess the safety of a regimen of LABAs plus inhaled corticosteroids as compared with inhaled corticosteroids alone.
THE ACTION OF LOCALLY APPLIED BARBITURATES ON SKIN OXYGEN TENSION AND RATE OF OXYGEN UTILIZATION
Authors: P. F. D. NAYLOR, N. T. S. EVANS
Journal: British Journal of Dermatology (1970)

Journal Article THE ACTION OF LOCALLY APPLIED BARBITURATES ON SKIN OXYGEN TENSION AND RATE OF OXYGEN UTILIZATION Get access P. F. D. NAYLOR, P. F. D. NAYLOR Departments of Dermatology and Medicine, St Thomas'Hospital and Medical School, London, S.E. 1, and Medical Research Council Experimental Radiopathology Unit, Hammersmith Hospital, London, W.12 Search for other works by this author on: Oxford Academic Google Scholar N. T. S. EVANS N. T. S. EVANS Departments of Dermatology and Medicine, St Thomas'Hospital and Medical School, London, S.E. 1, and Medical Research Council Experimental Radiopathology Unit, Hammersmith Hospital, London, W.12 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 82, Issue 6, 1 June 1970, Pages 600–605, https://doi.org/10.1111/j.1365-2133.1970.tb06101.x Published: 01 June 1970 Article history Accepted: 22 December 1969 Published: 01 June 1970
NICE to start assessing diagnostic and treatment procedures
Authors: Z. Kmietowicz
Journal: BMJ (2003)

Doctors and the public are being asked to take part in a groundbreaking new scheme to assess the safety and efficacy of all new procedures used for diagnosis or treatment in the health service.

The world's first system to register, codify, assess, and issue guidance on interventional procedures was launched last week by the National Institute for Clinical Excellence. The programme incorporates the previous voluntary system of the Safety and Efficacy Register for New Interventional Procedures (SERNIP), established in …
Clinical outcomes of Interleukin-2 therapy in advanced cancer: meta-analysis of over 62 trials
Authors: Brendon J Coventry, Martin L Ashdown, Richard Bright
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Interleukin-2 (IL2) therapy for cancer has stood the test of time, with continued widespread use with clinical complete responses (CR) variably reported at 5%-20% for advanced malignant melanoma, renal cell carcinoma, and a range of other cancers. IL-2 is recognized to be curative
Cardiac fibroblast actions of cardiotrophin-1 and its receptor complex with crosstalk with the endothelin system in vitro: modulation by early dilated cardiomyopathy
Authors: Toshihiro Tsuruda, Brenda Huntley, Guido Boerrigter, Alessandro Cataliotti, Shang C. Lee, Horng H. Chen, Lisa C. Costello, John C. Burnett
Journal: Journal of the American College of Cardiology (2002)
Hidden Bias in Research Design
Authors: Lawrence D. Grouse
Journal: JAMA (1980)

I believe that most physicians have had the experience of seeing patients with what are generally considered serious diseases— diseases associated with substantial mortality or morbidity according to the textbooks—and were surprised at how many of these patients do remarkably well, not appearing to follow the morbid textbook course at all. Seen, perhaps, for some minor, unrelated problem, their serious disease may remain totally quiescent, indefinitely. Such experiences make one doubtful of the accuracy of original diagnoses or, in moments of skepticism, make one wonder whether patients referred to academic centers do worse than unreferred (and unreported) cases for reasons other than the pathophysiology of their disease. An article published in this issue ofThe Journalby Ellenberg and Nelson (p 1337) may shed some light on this paradox. When studying children with febrile seizures, these investigators find that clinic-based studies may have reported on a biased spectrum of patients.
Cardiac Rehabilitation and Secondary Prevention of Coronary Heart Disease
Authors: Philip A. Ades
Journal: New England Journal of Medicine (2001)

Coronary heart disease is the leading cause of death in the United States among men and women.1 It is also a major cause of physical disability, particularly in the rapidly growing population of elderly persons.2,3 In 1997, acute myocardial infarction was diagnosed in 1.1 million Americans, and 800,000 patients underwent coronary revascularization.1 The prevention of subsequent coronary events and the maintenance of physical functioning in such patients are major challenges in preventive care.Cardiac-rehabilitation programs were first developed in the 1960s,46 once the benefits of ambulation during prolonged hospitalization for coronary events had been recognized.7 After discharge from . . .
Tachycardia-Related Channel in the Scar Tissue in Patients With Sustained Monomorphic Ventricular Tachycardias
Authors: Angel Arenal, Silvia del Castillo, Esteban Gonzalez-Torrecilla, Felipe Atienza, Mercedes Ortiz, Javier Jimenez, Alberto Puchol, Javier García, Jesús Almendral
Journal: Circulation (2004)

Endocardial mapping before sustained monomorphic ventricular tachycardia (SMVT) induction may reduce mapping time during tachycardia and facilitate the ablation of unmappable VT.Left ventricular electroanatomic voltage maps obtained during right ventricular apex pacing in 26 patients with chronic myocardial infarction referred for VT ablation were analyzed to identify conducting channels (CCs) inside the scar tissue. A CC was defined by the presence of a corridor of consecutive electrograms differentiated by higher voltage amplitude than the surrounding area. The effect of different levels of voltage scar definition, from 0.5 to 0.1 mV, was analyzed. Twenty-three channels were identified in 20 patients. The majority of CCs were identified when the voltage scar definition was < or =0.2 mV. Electrograms with > or =2 components were recorded more frequently at the inner than at the entrance of CCs (100% versus 75%, P< or =0.01). The activation time of the latest component was longer at the inner than at the entrance of CCs (200+/-40 versus 164+/-53 ms, P< or =0.001). Pacing from these CCs gave rise to a long-stimulus QRS interval (110+/-49 ms). Radiofrequency lesion applied to CCs suppressed the inducibility in 88% of CC-related tachycardias. During a follow-up of 17+/-11 months, 23% of the patients experienced a VT recurrence.CCs represent areas of slow conduction that can be identified in 75% of patients with SMVT. A tiered decreasing-voltage definition of the scar is critical for CC identification.
Oxygen therapy for pneumatosis coli.
Authors: R H Down, W M Castleden
Journal: BMJ (1975)

Pneumatosis coli is an uncommon condition of unknown aetiology which is characterized by multiple gas-filled cysts in the submucosa of the colon.The cysts vary in size from a few millimetres to one or two centimetres and may obliterate the bowel lumen.We describe here a patient with incapacitating symptoms from rectosigmoid pneumatosis coli who was treated with a high concentration of oxygen, a form of simple, safe, and effective therapy not widely known. Case ReportTh:s patient had successfully undergone aortic and mitral valve r,placement for rheumatic valve disease in February 1971 when she was 55 years old.Apart from the injection of bleeding ha.morrhoids with sclerosant twice in 1972 she had had a normal bowel habit.In May 1973 she complained of passing loose motions two or three times a day and excessive flatus per rectum.Sigmoidoscopy and a barium enema examination showed nothing abnormal.Four
Practical Gynecology: A Guide for the Primary Care Physician
Authors: Sara L. Jackson, Joann G. Elmore
Journal: Annals of Internal Medicine (2009)

Medical Writings: Book Notes3 November 2009Practical Gynecology: A Guide for the Primary Care PhysicianSara L. Jackson, MD, MPH and Joann G. Elmore, MD, MPHSara L. Jackson, MD, MPHFrom the University of Washington, Seattle, Washington.Search for more papers by this author and Joann G. Elmore, MD, MPHFrom the University of Washington, Seattle, Washington.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-9-200911030-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail 2nd ed. Ryden JB, Blumenthal PD, eds. 550 pages. Philadelphia: American Coll of Physicians; 2009. $74.95. ISBN 9781934465059. Order at www.acponline.org.Field of medicine: Gynecology and primary care.Format: Softcover book and CD-ROM.Audience: Primary care clinicians who care for female patients.Purpose: To provide primary care clinicians with an overview of basic gynecology and clinical issues related to the care of female patients and to assist in furthering their knowledge in areas of particular interest.Content: The book surveys the broad range of clinical issues commonly encountered in the provision of primary care to female patients. With chapters contributed ... Author, Article, and Disclosure InformationAffiliations: From the University of Washington, Seattle, Washington. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 November 2009Volume 151, Issue 9Page: 675KeywordsObstetrics and gynecologyPatientsPremenstrual syndromePrimary care physiciansSoftware design ePublished: 3 November 2009 Issue Published: 3 November 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Hypertonicity regulates the function of human neutrophils by modulating chemoattractant receptor signaling and activating mitogen-activated protein kinase p38.
Authors: W G Junger, D B Hoyt, R E Davis, C Herdon-Remelius, S Namiki, H Junger, W Loomis, A Altman
Journal: Journal of Clinical Investigation (1998)

Excessive neutrophil activation causes posttraumatic complications, which may be reduced with hypertonic saline (HS) resuscitation. We tested if this is because of modulated neutrophil function by HS. Clinically relevant hypertonicity (10-25 mM) suppressed degranulation and superoxide formation in response to fMLP and blocked the activation of the mitogen activated protein kinases (MAPK) ERK1/2 and p38, but did not affect Ca2+ mobilization. HS did not suppress oxidative burst in response to phorbol myristate acetate (PMA). This indicates that HS suppresses neutrophil function by intercepting signal pathways upstream of or apart from PKC. HS activated p38 by itself and enhanced degranulation in response to PKC activation. This enhancement was reduced by inhibition of p38 with SB203580, suggesting that p38 up-regulation participates in HS-induced enhancements of degranulation. HS had similar effects on the degranulation of cells that were previously stimulated with fMLP, but had no effect on its own, suggesting that HS enhancement of degranulation requires another signal. We conclude that depending on other stimuli, HS can suppress neutrophil activation by intercepting multiple receptor signals or augment degranulation by enhancing p38 signaling. In patients HS resuscitation may reduce posttraumatic complications by preventing neutrophil activation via chemotactic factors released during reperfusion.
FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States
Authors: Jongsook Kim Kemper, Zhen Xiao, Bhaskar Ponugoti, Ji Miao, Sungsoon Fang, Deepthi Kanamaluru, Stephanie Tsang, Shwu-Yuan Wu, Cheng-Ming Chiang, Timothy D. Veenstra
Journal: Cell Metabolism (2009)
A doctor's dilemma
Authors: M. Nelson-Owen
Journal: BMJ (1997)

It is difficult to criticise the working practices of other doctors. You leave medical school with a sense of belonging to a family of time honoured physicians who have given their lives to healing the sick and treating the needy. The Hippocratic oath tells us to be loyal to the profession of medicine, and just and generous to its members. You learn about the fundamentals of pharmaceutical practice—first do no harm. It is this last statement with which my conscience is struggling, and which is responsible for the dilemma I face.

There is a real problem out there—and it is not what it seems. I used to think—those junkies, they are no-hopers. How can you help people who don't care, or who don't want to help themselves? The reality is different. General practitioners and community drug team doctors have a lot to answer for.

I see many 17 year olds who come into prison on genuine repeat prescriptions of all sorts of addictive drugs such as diazepam, temazepam, methadone, dihydrocodeine—this can't be right. …
ANURIA FOR NINETY-SIX HOURS IN A TWO YEAR OLD INFANT FOLLOWING SULFAPYRIDINE THERAPY
Authors: Carl L. Wilson
Journal: JAMA (1941)

In the past eighteen months a number of reports have appeared in the literature regarding the possible renal complications of sulfapyridine therapy. By far the most serious of these is complete anuria with resultant uremia and death. Evidence has been presented by several authors to show that certain of the cases of anuria result from complete blockage of the lower part of the ureters by impacted crystals of acetylated sulfapyridine. In some instances relief has been obtained after cystoscopic manipulation and removal of the ureteral obstruction. It is our purpose to offer additional evidence (1) that anuria following sulfapyridine therapy may be due to complete obstruction of the lower part of the ureters by sediment or crystals and (2) that cystoscopic investigation should be employed when such anuria occurs. <h3>REPORT OF CASE</h3> A boy aged 2 years became ill with cough, fever and chills on Dec. 8, 1940, and his