tbuckley/cabot-search huggingface dataset:
THE VISSCHER-BOWMAN TEST FOR PREGNANCY
Authors: G. H. Dodds
Journal: BMJ (1936)

MTHE BRITISWodds that are unlikely because they are too low.(A more direct algebraic method is available, but is -rather com- plicated.)The reader should beware of a method some- times recommended-namely, to calculate a standard deviation from the sample itself and then set off twice this standard deviation on each side of the odds given by the sample, to mark the likely upper and lower limits of the true odds.This method is fairly safe when the odds are nearly even, but is not safe otherwise.
The speckled immunofluorescence of epidermal nuclei as an in vivo phenomenon
Authors: AURORA PARODI, E. NUNZI, A. REBORA
Journal: British Journal of Dermatology (2006)

The deposition of speckled-patterned immunoglobulins in epidermal nuclei has been investigated in seventeen patients with various diseases other than mixed connective tissue disease. The phenomenon was seen not only with low titres of circulating antinuclear antibodies of IgG and IgM classes, but even in their absence. The clinical significance of this finding remains obscure, but the common explanation, that it is a simple artifact, seems quite untenable.
Long-term continuous infusion of anti-GD2 antibody CH14.18/CHO in relapsed/refractory neuroblastoma patients
Authors: Holger Lode, Nikolai Siebert, Silke Kietz, Ina Müller, Manfred Schuster, Evelyne Janzek, Susanne Wiederkum, Oliver Mutschlechner, Hans Loibner
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts GD2 is highly expressed in neuroblastoma (NB) and specifically recognized by antibodies ch14.18. Immunotherapy with bolus infusion of ch14.18 in combination with cytokines prolonged survival in patients at risk for relapse but was associated with substantial toxicity, in
Causes and patterns of readmissions in patients with common comorbidities: retrospective cohort study
Authors: J. Donze, S. Lipsitz, D. W. Bates, J. L. Schnipper
Journal: BMJ (2013)

<b>Objective </b>To evaluate the primary diagnoses and patterns of 30 day readmissions and potentially avoidable readmissions in medical patients with each of the most common comorbidities. <b>Design</b> Retrospective cohort study. <b>Setting</b> Academic tertiary medical centre in Boston, 2009-10. <b>Participants</b> 10 731 consecutive adult discharges from a medical department. <b>Main outcome measures</b> Primary readmission diagnoses of readmissions within 30 days of discharge and potentially avoidable 30 day readmissions to the index hospital or two other hospitals in its network. <b>Results</b> Among 10 731 discharges, 2398 (22.3%) were followed by a 30 day readmission, of which 858 (8.0%) were identified as potentially avoidable. Overall, infection, neoplasm, heart failure, gastrointestinal disorder, and liver disorder were the most frequent primary diagnoses of potentially avoidable readmissions. Almost all of the top five diagnoses of potentially avoidable readmissions for each comorbidity were possible direct or indirect complications of that comorbidity. In patients with a comorbidity of heart failure, diabetes, ischemic heart disease, atrial fibrillation, or chronic kidney disease, the most common diagnosis of potentially avoidable readmission was acute heart failure. Patients with neoplasm, heart failure, and chronic kidney disease had a higher risk of potentially avoidable readmissions than did those without those comorbidities. <b>Conclusions</b> The five most common primary diagnoses of potentially avoidable readmissions were usually possible complications of an underlying comorbidity. Post-discharge care should focus attention not just on the primary index admission diagnosis but also on the comorbidities patients have.
Montreal cognitive assessment (MoCA): baseline evaluation of cognition in the athletic population
Authors: C T Debert, B W Benson, S Dukelow
Journal: British Journal of Sports Medicine (2013)

Objective To assess baseline pre-season cognitive function in a young adult athletic population using the Montreal Cognitive Assessment Tool (MoCA). Design Baseline case series of normative data. Setting Sport Medicine Clinic at the University of Calgary, Alberta, Canada. Participants Male and female athletes (n=347) were recruited from the University of Calgary varsity athletic teams, Southern Alberta Institute of Technology college teams and Canadian National sports teams. Athletes (aged 18–40 years) underwent pre-season face-to-face standardised cognitive screening interviews. Interventions Baseline biographical information and a pre-season MoCA test were performed. Main Outcome Measurements The MoCA is a one page global cognitive assessment tool with a maximum score of 30 points. Results All subjects had grade 12 education or greater. Fifty-nine percent of the population was male. The average age was 22.02±3.49. The overall mean MoCA score was 26.62±2.20. One hundred and one subjects (29%) scored less than 26. For contact/collision sport athletes and non-contact sport athletes the mean MoCA scores were 26.41±2.28 and 26.97±2.01 respectively. There was a significant difference (p=0.018) between the contact/collision and non-contact sport athletes scores. Conclusions Approximately 29% of the athletic population surveyed had MoCA scores less than what is considered normal (&lt;26). Contact/collision sport athletes had significantly lower MoCA's scores than non-contact sport athletes. Scores less than 26 have been associated with mild cognitive impairment and Alzheimer's dementia in other studies. Multiple factors (eg, previous concussion, non-documented head injuries, malingering, etc) may play a role in explaining the present findings. Competing interests None.
Diagnostic Electrocardiography and Vectorcardiography
Authors: David H. Spodick
Journal: JAMA (1971)

This comprehensive book replaces Dr. Friedman's well known<i>Outline</i>. Organization, completeness, and lucid presentation of often complex material makes this one of the best general electrocardiography texts. Its usefulness is amplified by unusually attractive typefaces and positioning of subheads. Readers will be grateful to Dr. Friedman for his knack of clarifying without oversimplifying the arcana of electrocardiography. Interference-dissociation, for example, becomes easier to understand because the author successfully unpeels from it long-standing terminologic encrustations. Newly understood concepts like hemiblock are equally well presented, while appropriate suspicion is cast on disproved hyperintellectualizations (eg, certain criteria for "left atrial rhythm") and statistically shaky measurements like the Macruz index. Dr. Friedman gives ample coverage to vectorcardiography and vector interpretation of the electrocardiogram, but avoids overselling them in clinical applications. Even the subspecialist will find his discussions of left and right ventricular hypertrophy clear and comprehensive with full attention to diagnostic pitfalls.
Recombinant human C1 inhibitor for the prophylaxis of hereditary angioedema attacks: a pilot study
Authors: A. Reshef, D. Moldovan, K. Obtulowicz, I. Leibovich, E. Mihaly, S. Visscher, A. Relan
Journal: Allergy (2012)

Abstract Background Hereditary angioedema ( HAE ) is a disease characterized by recurrent tissue swelling affecting various body locations. Recent literature shows that patients with frequent attacks may benefit from long‐term prophylaxis. This study evaluated the safety and prophylactic effect of weekly administrations of recombinant C1 INH (rhC1 INH ). Methods Patients with a history of HAE attacks occurring ≥every 2 weeks received a once weekly administration of 50 U/kg rh C 1 INH . Hereditary angioedema attack history was collected at screening. Breakthrough attacks during the study were recorded at each visit. Following a 2‐week run‐in period, HAE patients received 8 weekly rhC1 INH administrations and were followed‐up for an additional 6 weeks. Efficacy was evaluated by comparing the HAE attack incidence during the treatment period to the historical attacks over the previous 2 years. Safety evaluation was based on clinical laboratory and adverse events ( AE s) reports. Results The 25 participants reported a mean of 0.9 attacks/week over the past 2 years. The mean breakthrough attack rate during the treatment period was 0.4 attacks/week (95% CI 0.28–0.56). A total of 30 treatment‐emergent‐ AE s were reported in 13 patients, all mild to moderate. One patient died from a laryngeal attack 25 days after last study drug administration. The only possible drug related AE s reported were dry mouth, dizziness and anxiety in one patient and hypotension in another. There were no allergic AE s and no neutralizing antibodies observed. Conclusions Weekly administrations of 50 U/kg rh C 1 INH appeared to reduce the frequency of HAE attacks and were generally safe and well tolerated.
Retro-Orbital Hemorrhage after Thrombolysis for Acute Myocardial Infarction
Authors: Thomas S. Cunneen, Nigel Morlet
Journal: New England Journal of Medicine (2007)

rations, incudomalleolar dislocations, and sensorineural hearing loss.There were no burns in the ear canals or on the tympanic membranes, and scarring was not encountered during tympanoplasty.The patient was conscious at the scene and had no intracranial injuries, findings that would have been unlikely had lightning entered his head.
CONTRIBUTION TO THE SURGERY OF GASTRIC ULCER.
Authors: VAN BUREN KNOTT
Journal: JAMA (1903)

The Treatment of Vasomotor Suppression of Urine.-It has been demonstrated that the pathologic lesion in this condition is an intense venous congestion of kidney.The blood is stagnant, the venous return is progres¬ sively more and more impaired by lateral pressure, the kidney capsule is tensely overfilled, and blood is being continuously pumped into an already overfull organ.This kidney certainly needs depletion and those meas¬ ures should be applied which will withdraw blood from it.Diuretics may act favorably on such a kidney or they may be the very worst possible thing for it.The lesion is uniformly a greatly impeded venous return from the organ or a venous stasis.Now, if by increasing the arterial pressure behind this stagnant blood it can be forced on into the renal vein, then a diuretic will relieve the existing stasis and render conditions favorable to an absorption of any exúdate that may be present.Such reasoning is followed in the treatment of pneumonia, and the heart receives more attention from the thera¬ peutic standpoint than the lung itself.If, however, the obstructive lesion in the veins has become so marked that this piling up of pressure from behind can not over¬ come it, then these same drugs only intensify the lesion by sending more and more blood to the organ.It seems to the writer, therefore, that the course pursued in the treatment of the reported case was cor¬ rect.Fresh infusion of digitalis was first given with a view to strengthening the heart, equalizing the circula¬ tion and restoring vasomotor tone.This failing it was deemed wise to establish a high degree of hydremic plethora by the most prompt possible means.Sixty ounces of normal salt solution were therefore injected into the veins every six hours for four doses.This measure also failed in this particular case, and in the light of subsequent history both measures probably did her kidneys more harm than good.Nevertheless, it is believed that these measures are correct and that they will serve to re-establish the flow of blood through the kidney, hence the flow of urine, in quite a percent¬ age of very early cases.Depleting agencies will occupy a position of high im¬ portance in the treatment.These measures are applied for two reasons : ( 1 ) For the purpose of withdrawing blood from the kidney; (2) for the purpose of removing urea from the blood.To this end cupping of the loins, free purgation and sweating with pilocarpin and hot air are to be strongly recommended.Large hot irriga¬ tions of the colon with salt solution may be tried.OPERATIVE TREATMENT.
Do Don Juans have better genes than family men?
Authors: Alice H. Eagly
Journal: Behavioral and Brain Sciences (2000)

An alternative interpretation of Gangestad &amp; Simpson's findings features the assumption that only a subgroup of those men who are low in fluctuating asymmetry are typically available for short-term mating. In general, these philandering men do not offer higher genetic quality than men who are securely attached to long-term mates.
Effect of endobronchial aspirin challenge on inflammatory cells in bronchial biopsy samples from aspirin-sensitive asthmatic subjects.
Authors: S. Nasser, P. E. Christie, R. Pfister, A. R. Sousa, A. Walls, M. Schmitz-Schumann, T. H. Lee
Journal: Thorax (1996)

BACKGROUND: The aspirin-induced bronchoconstriction in patients with aspirin-sensitive asthma is caused by cysteinyl leukotriene release. The cellular source of the leukotrienes is unknown. The inflammatory cell infiltrate in bronchial biopsy samples from seven aspirin-sensitive asthmatic (ASA) subjects and eight non-ASA subjects before and after local challenge with lysine aspirin was therefore examined. METHODS: Using flexible bronchoscopy, airway mucosal biopsy samples were taken and lysine aspirin solution was placed directly onto a carina of the contralateral lung. Twenty minutes later a second series of biopsy samples was taken from the site of the local endobronchial lysine aspirin challenge. The biopsy samples were double immunostained with a rabbit polyclonal antibody to the enzyme 5-lipoxygenase and monoclonal antibodies to mast cells (AA1), neutrophils (NP57), macrophages (EBM11), T lymphocytes (anti-CD3), and total (BMK13) and activated eosinophils (EG2). RESULTS: A decrease in both absolute mast cell numbers staining with mast cell tryptase (AA1) and the percentage of mast cells co-immunostaining with 5-lipoxygenase was seen in the ASA patients after lysine aspirin challenge compared with the non-ASA control group. There was also an increase in the numbers of activated eosinophils (EG2) in the ASA subjects compared with the non-ASA group. No changes were observed in the total numbers of macrophages (EBM11), neutrophils (NP57), total eosinophils (BMK13), and T lymphocytes (anti-CD3) after challenge with lysine aspirin. CONCLUSIONS: The decrease in numbers of mast cells staining for tryptase and the increase in activated eosinophils after endobronchial challenge with lysine aspirin may represent degranulation of these cell types, and may be an early event associated with aspirin-sensitive reactions in ASA subjects.
Choroidal Volume Variations with Age, Axial Length, and Sex in Healthy Subjects: A Three-Dimensional Analysis
Authors: Giulio Barteselli, Jay Chhablani, Sharif El-Emam, Haiyan Wang, Janne Chuang, Igor Kozak, Lingyun Cheng, Dirk-Uwe Bartsch, William R. Freeman
Journal: Ophthalmology (2012)
Spirometric values in 540 healthy schoolboys
Authors: Petia L. Kamburoff, D. A. Brodie
Journal: British Journal of Sports Medicine (1971)

Recently physical educationists have become interested in indices of lung function.This is very fortunate because tests of lung function are now widely used by the medical profession in assessing the severity of respiratory diseases, two of which are increasingly prevalent :-asthma and chronic bronchitis.It is very valuable indeed both from the point of view of the individual patient and from the wider point of view of the epidemiologist to have results of this kind which go as far back as possible in the history of the patient.From an entirely different standpoint these data are an important index of health.There is a great need for a reliable body of normal values for these tests in the age range covered by school life.There is some evidence from the reliable tables which have already been published (Berlund, et al. (1963), Cherniack (1962) Godfrey,Kamburoff, and Nairn (1970) and Pistana (1969))that regional and national variations in normal values occur.For these reasons the following tables are published for the use of those interested for comparison with their own observations.Techniques and population.
PRIMARY CARCINOMA OF LIVER WITH SPONTANEOUS RUPTURE
Authors: William H. Mast
Journal: JAMA (1933)

Review of this case is undertaken because of the infrequent occurrence of spontaneous rupture of a primary carcinoma of the liver, simulating an acute surgical condition of the abdomen. A white man, aged 34, was admitted to the hospital, Oct. 12, 1932, with a diagnosis of ruptured peptic ulcer, made by a physician in a neighboring town. The family history revealed the fact that a maternal grandfather and one brother were supposed to have had congenital syphilis. The past history was negative for serious illness, operations or injuries. About six years before, the patient had consulted a physician because of gas and constipation. At that time he was told that he had "liver and heart trouble." He was given medicine which relieved him so much that he was able to resume his work on the farm. During the past six years he had been fairly comfortable, although he had suffered
TCT-763 Clinical Profiles and Outcomes of Nonagenarians Undergoing Transcatheter Aortic Valve Replacement
Authors: Nevin C. Baker, Marco A. Magalhaes, Ricardo O. Escarcega, Sa'ar Minha, Michael J. Lipinski, Thibault Lhermusier, lakshmana Pendyala, Wenjie Tian, Hideaki Ota, William O. Suddath, Lowell F. Satler, Augusto Pichard, Rebecca Torguson, Ron Waksman
Journal: Journal of the American College of Cardiology (2014)
Dizziness and Headache: Another Look at Complaint-centered Medicine
Authors: Robert Jaffee
Journal: JAMA (1973)

A tendency to expansion in the number and variety of complaint-centered clinics is evident. This approach is based on the belief that increased efficiency and better results can be obtained in this way. Careful analysis of the trend, however, reveals it to be a symptom of the breakdown of proper health-care delivery mechanisms, and in itself potentially dangerous and inherently inefficient.  Treat the person, not the symptom; maintain health instead of treating illness. Slogans such as these represent good principles and seem so patently unchallengeable that they might be the basic currency for almost any medical graduation speech or presidential address. In spite of this, however, we see a paradoxical persistence, even expansion of the tendency to focus not only on specific illnesses, but even on specific complaints.  A recent news release hailed the activity of a new headache clinic ( New York Post , April 13, 1972, p 28) a scientific
Minocycline-induced Cell-mediated Hypersensitivity Pneumonitis
Authors: Jean-Marcel Guillon, Pascal Joly, Brigitte Autran, Michel Denis, Georges Akoun, Patrice Debré, Charles Mayaud
Journal: Annals of Internal Medicine (1992)

▪Objective: To identify the cause of a hypersensitivity pneumonitis and to determine its pathogenesis. ▪Design: Case study. ▪Setting: Intensive care unit of a referral hospital. ▪Patient: A 51-year-old man with chronic bronchitis who developed a hypersensitivity pneumonitis within 1 month after exposure to minocycline, amoxicillin, and erythromycin. ▪Intervention: Sequential bronchoalveolar lavages after reexposure to minocycline and amoxicillin. ▪Measurements: Immunologic analysis of the phenotype and function of alveolar lymphocytes. ▪Results: Reexposure to minocycline but not to amoxicillin was followed by an interstitial pneumonitis. Sequential bronchoalveolar lavages showed a transient rise of eosinophils and neutrophils and a persistent alveolar lymphocytosis. Alveolar lymphocytes consisted predominantly of CD8+ but also CD4+ cells. Two C08+ lymphocyte subsets were identified: CD8+ D44+ cytotoxic T cells that increased rapidly after the drug was resumed and CD8+ CD57+ suppressor T cells that predominated 11 days after the drug's withdrawal. In-vitro assays showed the presence of a lymphocyte-mediated specific cytotoxicity against minocycline-bearing alveolar macrophages. ▪Conclusion: These results support the hypothesis of a central role of T lymphocytes in the pathogenesis of drug-related hypersensitivity pneumonitis.
Luminal endocytosis and intracellular targeting by acinar cells during early biliary pancreatitis in the opossum.
Authors: M M Lerch, A K Saluja, M Rünzi, R Dawra, M L Steer
Journal: Journal of Clinical Investigation (1995)

Cell necrosis in acute experimental pancreatitis is preceded by a redistribution of digestive enzymes into a lysosomal subcellular compartment. We have investigated whether endocytosis from the acinar cell lumen might contribute to this disturbance of intracellular compartmentation. In an animal model of pancreatitis involving pancreatic bile duct ligation in opossums, we have studied in vivo endocytosis of dextran 40 and [14C]dextran 70, cationized ferritin, and horseradish peroxidase from the apical surface of acinar cells before the onset of necrosis. Marker solutions were instilled into the pancreatic duct of anesthetized animals at physiological pressure. Tissue samples obtained at intervals of up to 60 min after instillation of markers were studied by electron microscopy and electron microscope autoradiography. All markers were taken up by acinar cells in control animals and in animals with obstructed pancreatic bile ducts. Markers for membrane-mediated endocytosis (cationated ferritin and horseradish peroxidase) were transported to lysosomes in both groups. In contrast, the fluid-phase tracer dextran was transported to the secretory pathway in controls but to lysosomes after duct ligation. Since dextran and luminally present secretory proteins can be expected to follow the same route after endocytosis, our findings suggest that altered intracellular targeting of endocytosed proteases might be one mechanism by which digestive zymogens reach an intracellular compartment in which premature activation can occur. This phenomenon may be a critical and early event in the pathogenesis of biliary pancreatitis.
Recommendations for the Analysis of ALK Gene Rearrangements in Non–Small-Cell Lung Cancer: A Consensus of the Italian Association of Medical Oncology and the Italian Society of Pathology and Cytopathology
Authors: Antonio Marchetti, Andrea Ardizzoni, Mauro Papotti, Lucio Crinò, Giulio Rossi, Cesare Gridelli, Massimo Barberis, Eugenio Maiorano, Nicola Normanno, Gian Luigi Taddei, Giorgio Scagliotti, Claudio Clemente, Carmine Pinto
Journal: Journal of Thoracic Oncology (2013)
Association of Cystic Fibrosis with Abnormalities in Fatty Acid Metabolism
Authors: Steven D. Freedman, Paola G. Blanco, Munir M. Zaman, Julie C. Shea, Mario Ollero, Isabel K. Hopper, Deborah A. Weed, Andres Gelrud, Meredith M. Regan, Michael Laposata, Juan G. Alvarez, Brian P. O'Sullivan
Journal: New England Journal of Medicine (2004)

Patients with cystic fibrosis have altered levels of plasma fatty acids. We previously demonstrated that arachidonic acid levels are increased and docosahexaenoic acid levels are decreased in affected tissues from cystic fibrosis–knockout mice. In this study we determined whether humans with mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene have a similar fatty acid defect in tissues expressing CFTR.
THE MILITARY STATUS OF DR. LEE ALEXANDER STONE
Authors: M. W. Ireland
Journal: JAMA (1924)

<h3>To the Editor:</h3> —Owing to a clerical error (misfiling of index card), the appointment of Dr. Lee Alexander Stone as major in the Medical Officers' Reserve Corps to rank from May 16, 1919, and his continuance in that grade until transferred to the Military Intelligence Officers' Reserve Corps, April 5, 1923, was not credited in my communication toThe Journal, September 27, p. 1021. While the statement in the last paragraph of my letter, "He did not reenter the medical service, and so far as the Medical Department is concerned, has had no connection with it since his discharge," is inaccurate, Dr. Stone ceased to be an officer of the Medical Section of the Officers' Reserve Corps, April 5, 1923, by transfer to the Military Intelligence, Officers' Reserve Corps; and was not, therefore, an officer of the Medical Department of the Army at the time of publication of his article.