Alcohol, Other Drugs, and the Liver
Authors: Emanuel Rubin, Charles S. Lieber
Journal: Annals of Internal Medicine (1968)

Editorials1 November 1968Alcohol, Other Drugs, and the LiverEMANUEL RUBIN, M.D., CHARLES S. LIEBER, M.D.EMANUEL RUBIN, M.D., CHARLES S. LIEBER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-69-5-1063 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the last decade numerous biochemical and ultrastructural studies have greatly expanded our understanding of the mechanisms involved in drug metabolism. Comprehensive recent reviews of this subject include those of Conney (1), Remmer (2), and Gillette (3). Most exogenous substances—such as pharmacologic agents, carcinogens, and insecticides—are detoxified by enzyme systems located in the microsomal fraction of the liver cell, which corresponds to the membranes of the endoplasmic reticulum seen with the electron microscope. 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CANCERENHANCEMENT OF BILIRUBIN CLEARANCE AND HEPATIC HÆM TURNOVER BY ETHANOLDrug InteractionsThe Effect of Physical Environmental Factors on Drug ResponseCNS Drugs Analgesics and AntipyreticsTHE PROGRAM AT MOUNT SINAI SCHOOL OF MEDICINE AND IMPLICATIONS FOR TEACHING ALCOHOLIC LIVER DISEASEAlcohol and the liver.Ethanol binding to hepatic microsomes—its increase by ethanol consumptionInhibition of drug metabolism by acute ethanol intoxicationImmunologische Ph�nomene bei Leberkrankheiten: Die Bedeutung mitochondrialer Antik�rperA TEST FOR ALCOHOLISM?ETHANOL AND NEONATAL BILIRUBIN LEVELS 1 November 1968Volume 69, Issue 5Page: 1063-1067KeywordsCarcinogensCell membranesDetoxificationDrug metabolismDrugsElectron microscopyEnzymesExcretionLipidsLiver Issue Published: 1 November 1968 PDF downloadLoading ...