tbuckley/cabot-search huggingface dataset:
Isolating Borrelia burgdorferi from Erythema Migrans
Authors: William A. Agger
Journal: Annals of Internal Medicine (1993)

Letters1 November 1993Isolating Borrelia burgdorferi from Erythema MigransWilliam A. Agger, MDWilliam A. Agger, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-9-199311010-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Erythema migrans can mimic other circular, erythematous eruptions. The isolation of Borrelia burgdorferi from erythema migrans can establish the diagnosis of Lyme disease [1]; 86% of skin biopsy cultures of erythema migrans lesions were reported to grow B. burgdorferi[2]. However, biopsies are time-consuming, expensive, and more invasive than needle aspiration. Recently, a double-needle cutaneous lavage of saline was found to be slightly less sensitive than skin biopsy, but because of the discomfort of saline injection, Xylocaine anesthesia was required [3].From June to September in 1991 and 1992, a single needle was used to aspirate erythema migrans ...References1. Dennis DT, Campbell GL, Quan TJ. Isolation of Borrelia burgdorferi from a patient infected in Maryland (Letter). Clin Infect Dis. 1992; 15:1058-9. Google Scholar2. Berger BW, Johnson RC, Kodner C, Coleman L. Cultivation of Borrelia burgdorferi from erythema migrans lesions and perilesional skin. J Clin Microbiol. 1992; 30:359-61. Google Scholar3. Wormser GP, Forseter G, Cooper D, Nowakowski J, Nadelman RB, Horowitz H, et al. Use of a novel technique of cutaneous lavage for diagnosis of Lyme disease associated with erythema migrans. JAMA. 1992; 268:1311-3. Google Scholar4. Callister SM, Agger WA, Schell RF, Ellingson JL. Borrelia burgdorferi infection surrounding La Crosse, Wisconsin. J Clin Microbiol. 1988; 26:2632-6. Google Scholar5. Jobe DA, Callister SM, Schell RF. Recovery of Borrelia burgdorferi by filtration. J Clin Microbiol. 1993; 31:1896-8. Google Scholar Author, Article, and Disclosure InformationAuthors: William A. Agger, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClinical Comparison of Borreliacidal-Antibody Test With Indirect Immunofluorescence and Enzyme-Linked Linked Immunosorbent Assays for Diagnosis of Lyme Disease 1 November 1993Volume 119, Issue 9 Page: 953-954 Keywords Anesthesia Bacteria Biopsy Borrelia burgdorferi Enzyme immunoassay Erythema Lesions Lyme disease Microscopy Outpatients ePublished: 15 August 2000 Issue Published: 1 November 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5–induced eosinophil development
Authors: Netali Ben Baruch-Morgenstern, Dana Shik, Itay Moshkovits, Michal Itan, Danielle Karo-Atar, Carine Bouffi, Patricia C Fulkerson, Diana Rashkovan, Steffen Jung, Marc E Rothenberg, Ariel Munitz
Journal: Nature Immunology (2013)
Influence of etiology on the survival advantage of women with advanced heart failure
Authors: Jalal K. Ghali, Heidi J. Krause-Steinrauf, Kirkwood F. Adams, Steven S. Khan, Yves D. Rosenberg, Clyde W. Yancy, James B. Young, Steven Goldman, Mary A. Peberdy, JoAnn Lindenfeld
Journal: Journal of the American College of Cardiology (2003)
Absolute lymphocyte count at the time of first relapse predicts survival in patients with diffuse large B‐cell lymphoma
Authors: Luis F. Porrata, Kay Ristow, Thomas M. Habermann, Thomas E. Witzig, David J. Inwards, Svetomir N. Markovic
Journal: American Journal of Hematology (2008)

Abstract Peripheral blood absolute lymphocyte count (ALC) is a survival prognostic factor in hematological malignancies. No reports have addressed whether ALC at the time of first relapse (ALC‐R) predicts survival. Thus, we assessed the prognostic significance of ALC‐R in diffuse large B‐cell lymphoma (DLBCL). Patients were required to have been diagnosed with first relapsed DLBCL, have ALC‐R values, and to be followed at Mayo Clinic, Rochester. From Feb 1987 until March 2006, 97 first relapsed DLBCL patients qualified for the study. The overall survival (OS) and progression‐free survival (PFS) were measured from the time of first relapse. The value of ALC‐ R ≥ 1.0 × 10 9 /L was used for the analysis. Both groups (ALC‐R ≥ 1 or &lt; 1 × 10 9 /L) were balanced for the international prognostic index at relapse (IPI‐R) ( P = 0.3), and for autologous stem cell transplantation ( P = 0.4). Superior OS and PFS were observed with an ALC‐R ≥ 1.0 × 10 9 /L ( N = 60) versus ALC‐R &lt; 1.0 × 10 9 /L ( N = 37) [median OS: 28.7 months, 5 years OS rates of 39% versus median OS: 10.2 months, 5 years OS rates of 14%, P &lt; 0.002; and median PFS: 14.8 months, 5 years PFS rates of 21% versus median PFS: 6.5 months, 5 years PFS rates of 8%, P &lt; 0.004, respectively]. ALC‐R was an independent prognostic factor for OS [RR = 0.4, P &lt; 0.01] and PFS [RR = 0.5, P &lt; 0.005]. ALC‐R predicts survival suggesting that host immunity is an important variable predicting survival in first relapsed DLBCL. Am. J. Hematol. 2009. © 2008 Wiley‐Liss, Inc.
Abnormal cells in Hodgkin's disease.
Authors: S Varadi
Journal: BMJ (1972)

days may be useful.If the flap necroses it must be removed early as described, but in favourable cases the flap will survive and grafting will be avoided.Spontaneous heal- ing will occur under a Viscopaste bandage with the patient ambulant.I cannot under- stand why Mr. David uses the medial aspect of the thigh as a donor site.The postero- lateral aspect is muwh safer to use, but in the elderly the deltoid region is even better as it allows early ambulation.-Iam, etc.,
Persistent rhinitis – allergic or nonallergic?
Authors: C. Bachert
Journal: Allergy (2004)

Summary Although rhinitis has been classified as being either allergic, noninfectious, or ‘‘other forms’’ (nonallergic noninfectious), these categories lack strict classification criteria and often overlap. The term ‘‘nonallergic noninfectious rhinitis’’ is commonly applied to a diagnosis of any nasal condition, in which the symptoms are similar to those seen in allergic rhinitis but an allergic aetiology has been excluded. This group comprises several subgroups with ill‐defined pathomechanisms, and includes idiopathic rhinitis, irritative‐toxic (occupational) rhinitis, hormonal rhinitis, drug‐induced rhinitis, and other forms (non‐allergic rhinitis with eosinophilia syndrome [NARES], rhinitis due to physical and chemical factors, food‐induced rhinitis, emotion‐induced rhinitis, atrophic rhinitis). Unlike allergic rhinitis, there are no specific diagnostic tests and diagnosis is primarily based on a history of reaction to specific irritant‐toxic triggering agents (either general or occupational), drugs, infections, and hormonal status, coupled with exclusion of allergic rhinitis and other forms of non‐allergic rhinitis by skin prick testing. Accordingly, from a clinical standpoint NARES, irritative‐toxic, hormonal, drug‐induced and idiopathic rhinitis are possibly the least difficult forms of nonallergic rhinitis to diagnose.
Science, medicine, and the future: Contraception
Authors: D. T Baird, A. F Glasier
Journal: BMJ (1999)

The prevalence of contraceptive use is increasing worldwide, and in many countries over 75% of couples use effective methods.1 However, existing methods of contraception are not perfect, and their acceptability is limited by side effects and inconvenience. Even in developed countries where contraception is freely available, many unplanned pregnancies occur. There is thus a real need for new methods of contraception to be developed that are more effective, easier to use, and safer than existing methods. This article discusses current research into new forms of contraception and predicts what methods are likely to be used in the future.
INTERNAL AND EXTERNAL HEMORRHOIDS.WITH SPECIAL REFERENCE TO THEIR TREATMENT.
Authors: LEWIS H. ADLER
Journal: JAMA (1905)

I have been requested to address you on the subject of hemorrhoids, viewed so far as possible from the standpoint of making my remarks of value and interest to the general practitioner. Time permits of only a brief synopsis of the subject.  Without making a thorough examination of a given case, no certain diagnosis can be made and no plan of treatment can be carried out with any degree of satisfaction. In most departments of medicine this fundamental principle is carefully observed, but possibly owing to a false sense of modesty on the part of patients afflicted with rectal trouble, some physicians are led to treat such persons without an exploration, either visual or digital, of the affected region. Consequently, it is not an infrequent occurrence for me to see a patient with an external hemorrhoid, greatly aggravated by the vain efforts made to push it within the anus. This
Imagination is only as rational as the purpose to which it is put
Authors: Andrew Shtulman
Journal: Behavioral and Brain Sciences (2007)

Abstract Byrne's criteria for considering imagination rational do not accord with standard notions of rationality. A different criterion – that is, the correspondence between an inference strategy and its domain of application – is offered and illustrated with recent work on possibility judgment. This analysis suggests that, although imagination can be put to rational purposes, imagination itself should not be considered rational.
Incidence of Allergic Diseases in General Practice
Authors: N. J. T. Hamilton, B. Bendkowski
Journal: BMJ (1954)

Barrow-in-FurnessThe symptoms of allergic disorders depend upon the antigen-antibody reaction in the shock organ.Von Pirquet defined allergy as an " acquired specific altered capacity to react."Even after 50 years of research in this field, Pepys (1953) points out that this statement is still valid.The findings of a collagen lesion in serum sickness, periarteritis nodosa, lupus erythematosus, and rheumatic fever, and the improvement in these conditions after cortisone or A.C.T.H. therapy, suggest that allergic reactions might play some part in their aetiology.We decided to investigate the incidence of five of the com- mon allergic diseases in our practice-namely, bronchial asthma, allergic rhinitis, urticaria, atopic eczema, and drug allergy.The practice, an industrial one comprising about 4,000 patients, is carried on from two surgeries.Details of attendances and treatment are recorded daily in each surgery.The period of this investigation was from September 1, 1952, to September 1, 1953.
Eosinophil-mediated injury to lung parenchymal cells and interstitial matrix. A possible role for eosinophils in chronic inflammatory disorders of the lower respiratory tract.
Authors: W B Davis, G A Fells, X H Sun, J E Gadek, A Venet, R G Crystal
Journal: Journal of Clinical Investigation (1984)

Eosinophils are a common component of the inflammation of the lower respiratory tract that characterizes the interstitial lung disorders. Bronchoalveolar lavage analyses (n = 680) of 251 patients with interstitial lung disease demonstrated that eosinophils represented greater than 5% of the effector cells comprising the alveolitis in 20% of all lavages. In contrast, lavage of normal individuals (n = 117) showed that eosinophils were never greater than 5% of the total effector cells recovered. To evaluate a possible role for eosinophils in mediating some of the cellular and connective tissue matrix derangements of the lung parenchyma found in interstitial disease, eosinophils were evaluated for the presence of proteases capable of cleaving connective tissue proteins found in the lung and for the ability to mediate cytotoxicity to lung parenchymal cells. Evaluation of guinea pig and human eosinophils demonstrated that eosinophil granules contained a collagenase that specifically cleaved human collagen types I and III, the two major connective tissue components of the human lung parenchyma. In contrast, the eosinophil did not contain an elastase or a nonspecific neutral protease. The eosinophil collagenase appeared to be a metalloprotease, as it was inhibited by ethylenediaminetetraacetate but not by phenylmethanesulfonyl-fluoride or alpha 1-antitrypsin. The eosinophil also has the capacity to injure lung parenchymal cells. Without further stimulation, eosinophils purified from peritoneal exudates of guinea pigs demonstrated spontaneous cytotoxicity for human lung fibroblasts (HFL-1), cat lung epithelial cells (AK-D) and rat lung mesothelial cells (I6B). Under identical conditions, the epithelial cells were more sensitive to eosinophil-mediated cytotoxicity than the fibroblasts or mesothelial cells (P less than 0.01), consistent with the clinical observation that in the interstitial disorders, the alveolar epithelial cells are damaged more commonly than fibroblasts or pleural cells. The eosinophil-mediated cytotoxicity could be partially inhibited by the antioxidants catalase and dimethylsulfoxide suggesting that toxic oxygen radicals play a role in mediating the cellular damage. Importantly, eosinophils purified from bronchoalveolar lavage of human interstitial lung disease also demonstrated spontaneous cytotoxicity for lung epithelial cells. These observations demonstrate that eosinophils are frequent participants of the alveolitis of the interstitial lung disorders and suggest that these cells have the potential to damage the parenchymal cells and collagen matrix of the lower respiratory tract.
Sinus of Valsalva Aneurysm With Rupture Into the Interventricular Septum and Left Ventricular Cavity
Authors: T. Wells, B. Byrd, D. Neirste, C. Fleurelus
Journal: Circulation (1999)

A 23-year-old Haitian man presented with complaints of shortness of breath, dyspnea on exertion, and occasional palpitations.Examination revealed a wide pulse pressure and a continuous murmur across the precordium.The echocardiogram showed a ruptured aneurysm of the right sinus of Valsalva (Figure 1).The sinus rupture dissected into the interventricular septum and then ruptured into the left ventricular cavity (Figures 2 and3).No operative intervention was undertaken.Aneurysms of the sinus of Valsalva account for only 1% of congenital cardiac anomalies.Of these aneurysms, 70% arise from the right sinus of Valsalva.Most of the remainder arise
DISAPPEARANCE OF IMMUNOGLOBULIN AND COMPLEMENT FROM THE ARTHUS REACTION AND ITS RELEVANCE TO STUDIES OF VASCULITIS IN MAN
Authors: J. J. CREAM, A. D. M. BRYCESON, G. RYDER
Journal: British Journal of Dermatology (1971)

Journal Article DISAPPEARANCE OF IMMUNOGLOBULIN AND COMPLEMENT FROM THE ARTHUS REACTION AND ITS RELEVANCE TO STUDIES OF VASCULITIS IN MAN Get access J. J. CREAM, J. J. CREAM Department of Immunology, Institute of Dermatology, St John's Hospital for Diseases of the Skin, Homerton Grove, London, E.9 Search for other works by this author on: Oxford Academic Google Scholar A. D. M. BRYCESON, A. D. M. BRYCESON Department of Immunology, Institute of Dermatology, St John's Hospital for Diseases of the Skin, Homerton Grove, London, E.9 Search for other works by this author on: Oxford Academic Google Scholar G. RYDER G. RYDER Department of Immunology, Institute of Dermatology, St John's Hospital for Diseases of the Skin, Homerton Grove, London, E.9 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 84, Issue 2, 1 February 1971, Pages 106–109, https://doi.org/10.1111/j.1365-2133.1971.tb06851.x Published: 01 February 1971 Article history Accepted: 17 September 1970 Published: 01 February 1971
Intercostal Muscle Contraction or Rib Bone Marrow Activity?
Authors: Sandip Basu, Saad Alzeair, Geming Li, Hongming Zhuang, Abass Alavi
Journal: Clinical Nuclear Medicine (2007)

Diffuse and uniform FDG uptake in the ribs and the intercostal muscles might appear similar on FDG-PET images and a reliable differentiation between the two is important for accurately identifying the underlying process. The former usually suggests excessive contraction of intercostal muscles mostly due to chronic obstructive pulmonary disease, whereas the latter signifies either bone marrow stimulation or involvement by a pathologic process. At times, images may appear confusing and may be misinterpreted. However, in both clinical settings, there are additional ancillary signs, which are helpful in making a correct diagnosis. We herein present 2 case vignettes from each category in which other ancillary signs helped to distinguish FDG rib uptake from intercostal muscle uptake.
Deep-Seated Mycotic Infections, Allergy to Fungi and Mycotoxins
Authors: Donald B. Louria
Journal: New England Journal of Medicine (1967)

INTEREST has increased markedly during the last decade in systemic fungous infections as well as in 2 disparate but related areas, pulmonary allergy to fungi and the extraordinary effects of mycotoxins. It seems appropriate to review some of the more interesting data concerning the pathogenesis, clinical manifestations and immunology of these sometimes life-threatening diseases. I shall make no attempt to be comprehensive but instead shall concentrate on the studies published for the most part during the last ten years that appear to me to be of greatest significance, and shall not discuss the therapeutic aspects of deep-seated mycotic infections. For . . .
Clinical and prognostic features of plasmacytomas: A multicenter study of Turkish Oncology Group‐Sarcoma Working Party
Authors: Sevil Kilciksiz, Omur Karakoyun Celik, Yucel Pak, Ayse Nur Demiral, Mustafa Pehlivan, Okan Orhan, Fusun Tokatli, Fulya Agaoglu, Burhanedtin Zincircioglu, Beste Melek Atasoy, Naciye Ozseker, Ozlem Yersal, Umar Niang, Ayfer Haydaroglu
Journal: American Journal of Hematology (2008)

Abstract To identify the outcomes of prognostic factors of solitary plasmacytoma mainly treated with local radiotherapy (RT). The data were collected from 80 patients with solitary plasmacytoma (SP). Forty patients (50.0%) received radiotherapy (RT) alone while 38 of them (47.5%) were treated with surgery (S) and RT. The median radiation dose was 46 Gy (range 30–64). The median follow up was 2.41 years (range 0.33–12.33). Ten‐year overall survival (OS) and local relapse‐free survival (LRFS) were 73% and 94%, respectively. The median progression‐free survival (PFS) and multiple myeloma‐free survival (MMFS) were 3.5 years and 4.8 years, respectively. On multivariate analyses, the favorable factors were radiotherapy dose of ≥50 Gy and RT + S for PFS and younger age for MMFS. For the patients with medullary plasmacytoma, the favorable factor was younger age for MMFS. RT at ≥50 Gy and RT + S may be favorable prognostic factors on PFS. Younger patients, especially with head‐neck lesion and without pre‐RT macroscopic tumor, seem to have the best outcome when treated with RT ± S. Progression to MM remains as the main problem especially for older patients. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.
Common variants in the HLA-DRB1–HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis
Authors: Michaela Fakiola, Amy Strange, Heather J Cordell, E Nancy Miller, Matti Pirinen, Zhan Su, Anshuman Mishra, Sanjana Mehrotra, Gloria R Monteiro, Gavin Band, Céline Bellenguez, Serge Dronov, Sarah Edkins, Colin Freeman, Eleni Giannoulatou, Emma Gray, Sarah E Hunt, Henio G Lacerda, Cordelia Langford, Richard Pearson, Núbia N Pontes, Madhukar Rai, Shri P Singh, Linda Smith, Olivia Sousa, Damjan Vukcevic, Elvira Bramon, Matthew A Brown, Juan P Casas, Aiden Corvin, Audrey Duncanson, Janusz Jankowski, Hugh S Markus, Christopher G Mathew, Colin N A Palmer, Robert Plomin, Anna Rautanen, Stephen J Sawcer, Richard C Trembath, Ananth C Viswanathan, Nicholas W Wood, Mary E Wilson, Panos Deloukas, Leena Peltonen, Frank Christiansen, Campbell Witt, Selma M B Jeronimo, Shyam Sundar, Chris C A Spencer, Jenefer M Blackwell, Peter Donnelly
Journal: Nature Genetics (2013)
Iron Status and Survival in Diabetic Patients With Coronary Artery Disease
Authors: Beata Ponikowska, Tomasz Suchocki, Bartłomiej Paleczny, Martyna Olesinska, Slawomir Powierza, Ludmila Borodulin-Nadzieja, Krzysztof Reczuch, Stephan von Haehling, Wolfram Doehner, Stefan D. Anker, John G.F. Cleland, Ewa A. Jankowska
Journal: Diabetes Care (2013)

OBJECTIVE To investigate the impact of iron status on survival in patients with type 2 diabetes and coronary artery disease (CAD). RESEARCH DESIGN AND METHODS Serum ferritin, transferrin saturation (Tsat), and soluble transferrin receptor (sTfR) were measured in 287 patients with type 2 diabetes and stable CAD (65 ± 9 years of age, 78% men). RESULTS During a mean follow-up of 45 ± 19 months, there were 59 (21%) deaths and 60 (21%) cardiovascular hospitalizations. Both serum ferritin and sTfR strongly predicted 5-year all-cause mortality rates, independently of other variables (including hemoglobin, measures of renal function, inflammation, and neurohormonal activation). There was an exponential relationship between sTfR and mortality (adjusted hazard ratio [HR] per 1 log mg/L: 4.24 [95% CI 1.43–12.58], P = 0.01), whereas the relationship between ferritin and mortality was U-shaped (for the lowest and the highest quintiles vs. the middle quintile [reference group], respectively: adjusted HR 7.18 [95% CI 2.03–25.46], P = 0.002, and adjusted HR 5.12 [1.48–17.73], P = 0.01). Similar patterns were observed for the composite outcome of all-cause mortality or cardiovascular hospitalization, and in these multivariable models, low Tsat was related to unfavorable outcome. CONCLUSIONS Both low and high serum ferritin (possibly reflecting depleted and excessive iron stores, respectively) along with high serum sTfR (reflecting reduced metabolically available iron) identify patients with type 2 diabetes and CAD who have a poor prognosis.
LONG-TERM THERAPY WITH BENDAVIA (MTP-131), A NOVEL MITOCHONDRIA-TARGETING PEPTIDE, REDUCES TOTAL BURDEN OF REACTIVE OXYGEN SPECIES IN LV MYOCARDIUM AND PLASMA OF DOGS WITH ADVANCED HEART FAILURE
Authors: Ramesh C. Gupta, Sharad Rastogi, Mengjun Wang, Kefei Zhang, Kristina J. Szekely, Paula Mohyi, Hani N. Sabbah
Journal: Journal of the American College of Cardiology (2014)
Familial occurrence of mitral valve prolapse in X-linked muscular dystrophy.
Authors: J H Biddison, D H Dembo, H Spalt, M G Hayes, C W LeDoux
Journal: Circulation (1979)

A high incidence of mitral valve prolapse (MVP) has been reported in patients with X-linked Duchenne muscular dystrophy. In our study MVP was present in six of 22 Duchenne dystrophy cases (27%) followed in the Maryland General Hospital Muscular Dystrophy Clinic. In addition, seven carriers of Duchenne and X-linked benign (Becker) dystrophy had evidence of MVP. Autosomal dominant transmission of MVP was present in four families. The unusually high prevalence of MVP in families with X-linked muscular dystrophy may have potential value in the recognition of the carrier trait.