tbuckley/cabot-search huggingface dataset:
The genetic factor influencing pulmonary hypertension in cattle at high altitude
Authors: E. K. WEIR, A. TUCKER, J. T. REEVES, D. H. WILL, R. F. GROVER
Journal: Cardiovascular Research (1974)

Journal Article The genetic factor influencing pulmonary hypertension in cattle at high altitude Get access E. K. WEIR, E. K. WEIR 2 2 University of Colorado Medical Centre, Cardiovascular Pulmonary Research Laboratory, Denver, Colorado, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar A. TUCKER, A. TUCKER 2 2 University of Colorado Medical Centre, Cardiovascular Pulmonary Research Laboratory, Denver, Colorado, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. T. REEVES, J. T. REEVES 2 2 University of Colorado Medical Centre, Cardiovascular Pulmonary Research Laboratory, Denver, Colorado, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar D. H. WILL, D. H. WILL Search for other works by this author on: Oxford Academic PubMed Google Scholar R. F. GROVER R. F. GROVER 2 2 University of Colorado Medical Centre, Cardiovascular Pulmonary Research Laboratory, Denver, Colorado, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 8, Issue 6, November 1974, Pages 745–749, https://doi.org/10.1093/cvr/8.6.745 Published: 01 November 1974
Guidelines for percutaneous transluminal coronary angioplasty. A report of the American Heart Association/American College of Cardiology Task Force on Assessment of Diagnostic and Therapeutic Cardiovascular Procedures (Committee on Percutaneous Transluminal Coronary Angioplasty).
Authors: T J Ryan, W B Bauman, J W Kennedy, D J Kereiakes, S B King, B D McCallister, S C Smith, D J Ullyot
Journal: Circulation (1993)
Advanced stage and unfavorable Hodgkin's disease in the Chinese?a 20-year experience
Authors: C.S. Chim, Y.L. Kwong, A.K.W. Lie, C.K. Lee, F.C.S. Ho, R. Liang
Journal: American Journal of Hematology (1999)

We retrospectively analyzed 57 patients with advanced stage (stage III/IV) or unfavorable (presence of B symptoms or bulky disease) Hodgkin's disease from January 1977 to December 1997. There were 29 male and 28 female patients. The median age was 27 years old (range, 13–59). Lactate dehydrogenase levels ranged from 104 units/l to 2320 units/l (median, 433). Eighteen (31.6%), 13 (22.8%), and 26 (45.6%) patients had stage II bulky, stage III, and stage IV disease, respectively. Twenty-five (44%) patients had B symptoms. One (1.8%), 3 (5.3%), 36 (63.2%), and 17 (29.8%) had lymphocyte predominant, lymphocyte depleted, nodular sclerosis, and mixed cellularity histology, respectively. Chemotherapy regimens included mechlorethamine, vincristine, procarbazine, prednisone (MOPP) (n = 9), adriamycin, bleomycin, vinblastine, dacarbazine (ABVD) (n = 23), MOPP alternating with ABVD (n = 13), and COPP-ABV hybrid (n = 12). Complete remission was achieved in 47 (82.4%) patients. Eleven patients (23%) relapsed after the first complete remission and four (36%) attained a second complete remission with salvage chemotherapy. Projected overall survival was 69.0% at 10 years and 20 years. Disease-free survival rates were 71% at 10 years and 20 years. Of the potential prognostic factors analyzed (age, sex, stage, lactate dehydrogenase, serum albumin level, regimen, B symptoms and bulky disease) by using the Cox regression model, only a low albumin level was found to adversely affect overall survival (P = 0.003). In conclusion, despite the relative low incidence of Hodgkin's disease in Hong Kong Chinese, the treatment outcomes in patients with advanced stage or unfavorable Hodgkin's disease is comparable to Caucasian patients. Am. J. Hematol. 61: 159–163, 1999. © 1999 Wiley-Liss, Inc.
Risk Stratification of Patients With Classic Angina Pectoris and No History of Coronary Artery Disease by Dobutamine Stress Echocardiography
Authors: Elena Biagini, Abdou Elhendy, Arend F.L. Schinkel, Jeroen J. Bax, Rizzello Vittoria, Ron T. van Domburg, Claudio Rapezzi, Maarten L. Simoons, Don Poldermans
Journal: Journal of the American College of Cardiology (2005)
1060 Iron re-accumulation following phlebotomy: implications for the use and value of phlebotomy in the treatment of hereditary haemochromatosis
Authors: E RYAN, S BARRETT, B COUGHLAN, B KELLEHER, F GLEESON, J CROWE
Journal: Hepatology (2003)

Since 1996, the identification of the HFE gene has enabled DNA testing for hereditary haemochromatosis (HH). The range of DNA testing available includes: (1) diagnostic, (2) predictive (also called presymptomatic testing) and (3) screening. Access to DNA testing has been facilitated by an Australian Medicare rebate, the first available for genetic disorders. Despite the availability of HFE DNA testing in HH, it remains necessary to interpret results in the context of the clinical picture. Traditional markers based on phenotype (transferrin saturation, ferritin and liver biopsy) are still required in some circumstances. We report our experience with HFE DNA testing using a semi-automated approach, which allows multiplexing for the two common mutations (C282Y and H63D). Screening a cohort of β-thalassaemia major and sickle cell anaemia patients of predominantly Mediterranean origin showed that these individuals do not have the common C282Y mutation. This excluded C282Y as a factor in the pathogenesis of iron overload in these haemoglobinopathies. It also showed that the C282Y mutation is of limited value when investigating HH in certain ethnic groups. An Australian family studied illustrated the relative contribution of C282Y and H63D in iron overload. A recently reported third mutation (S65C) in the HFE gene was detected in a low frequency in the populations tested.
Immunoglobulin kappa chain allotypes (KM) in onchocerciasis.
Authors: J P Pandey, L H Elson, S E Sutherland, R H Guderian, E Araujo, T B Nutman
Journal: Journal of Clinical Investigation (1995)

GM and KM allotypes, powerful tools for genetic characterization of human populations, have been shown to play an important role in genetic predisposition to some infectious diseases. Two diverse racial groups--Afro-Ecuadorians and Amerindians--living in a single restricted geographical area of Ecuador, appear to have different risk factors for acquisition and clinical expression of onchocerciasis, a disease caused by the filarial parasite Onchocerca volvulus. In this study, GM and KM allotypes were determined in 25 Afro-Ecuadorians and 24 Amerindians infected with Onchocerca volvulus (INF) and in putative immune individuals (PI). In Afro-Ecuadorians, the frequency of the homozygous KM 3 phenotype was significantly decreased in INF as compared with the PI group (20 vs. 68%; P= 0.0012), while the frequency of the heterozygous KM 1,3 phenotype was increased in INF as compared with the PI subjects (48 vs. 9%; P= 0.0044). These results suggest that in Afro-Ecuadorians KM 3 is associated with a lower relative risk (resistance), whereas KM 1,3 is associated with an increased risk (susceptibility) of onchocerciasis.
538. Fiber Chimeric Oncolytic Adenoviral Vectors Mediate Efficient Gene Transfer and Oncolysis of Head and Neck Cancer and Melanoma Cells In Vitro and In Vivo
Authors: Shanthi Ganesh, Yuanhao Li, P. Seshidhar Reddy, De-Chao Yu
Journal: Molecular Therapy (2005)

Current treatment modalities for melanoma and head and neck cancers (HNC) are not completely effective and there is an urgent need for development of novel therapeutic strategies. Oncolytic adenoviruses (OAVs) designed to selectively replicate and kill cancer cells are rapidly emerging as promising agents for oncolytic virotherapy. However, low expression levels of the adenovirus receptors, CAR and integrins in melanoma and HNC cells have imposed significant hurdles to the use of adenovirus type 5 (Ad5)-based vectors. To improve gene transfer and mediate efficient oncolysis of these cells, fiber chimeric vectors in which the fiber knob was replaced with the fiber knob domain of Ad35 were generated. Marker gene expression mediated by the fiber chimeric vectors in melanoma and HNC cell lines was approximately 10-fold higher than that obtained with parental Ad5 virus. The fiber chimeric structure was then built into an oncolytic adenovirus, in which the expression of the E1a gene is placed under the control of E2F-1 promoter. The cytotoxicity mediated by fiber chimeric vectors in melanoma and HNC cells was 100-fold better than that mediated by the parental Ad5 vector. In addition, the fiber chimeric structures improved the virus yields as much as 100-fold in several melanoma and HNC cells. These results correlated with low levels of CAR and high levels of CD46 on the surface of the cancer cell lines. The results of in vitro transduction, cytotoxicity and virus yields assays correlated with the results of in vivo anti-tumor efficacy studies in FaDu xenograft tumor model in nude mice. These findings have important implications for the potential treatment of melanoma and HNC using fiber chimeric oncolytic adenovirus.
Oral Urea in Sickle-Cell Disease
Authors: ROBERT M. NALBANDIAN
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 October 1972Oral Urea in Sickle-Cell DiseaseROBERT M. NALBANDIAN, M.D.ROBERT M. NALBANDIAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-4-659_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their paper (1), Lipp, Rudders, and Pisciotta reported the failure of urea therapy in the oral, prophylactic mode in five sickle-cell patients treated from 3½ to 7 weeks. Statistically significant increases in blood urea nitrogen (BUN) levels are cited, even though they indicate the specified BUN levels of 40 to 60 mg/100 ml (or higher), as required in our published protocols (2-4), were never achieved. Furthermore, the dosage schedule for urea therapy was significantly below that specified in our protocols. The beneficial effects of urea therapy in sickle-cell disease depend on achieving and maintaining adequate BUN...References1. LIPP E, RUDDERS R, and PISCIOTTA A: Oral urea therapy in sickle-cell anemia. A preliminary report. Ann Intern Med 76:765-768, 1972 LinkGoogle Scholar2. NALBANDIAN R, HENRY R, and SHULTZ G: Sickle cell crisis terminated by use of urea in invert sugar in two cases. U.S. Army Medical Research Laboratory Report No. 896, 17 September 1970 Google Scholar3. NALBANDIAN R, ANDERSON J, and LUSHER J: Oral urea and the prophylactic treatment of sickle cell disease. A preliminary report. Am J Med Sci 261:325-334, 1971 CrossrefMedlineGoogle Scholar4. NALBANDIAN R (editor): Molecular Aspects of Sickle Cell Disease: Clinical Applications. Springfield, Ill., Charles C Thomas, Publisher, 1971 Google Scholar1. SEGAL G, FEIG S, and MENTZER W: Effects of urea and cyanate on sickling in vitro. N Engl J Med 287:59-64, 1972 CrossrefMedlineGoogle Scholar2. MCCURDY P and MAHMOOD L: Intravenous urea treatment of the painful crisis of sickle-cell disease. A preliminary report. N Engl J Med 285:992-994, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT M. NALBANDIAN, M.D.Affiliations: Department of Laboratories Blodgett Memorial Hospital Grand Rapids, Mich. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1972Volume 77, Issue 4Page: 659-660KeywordsBlood urea nitrogenUrea ePublished: 1 December 2008 Issue Published: 1 October 1972 PDF downloadLoading ...
THE RELATION OF CORNEAL CURVATURES TO THE REFRACTION OF THE EYE.
Authors: MELVILLE BLACK
Journal: JAMA (1905)

I have included in this report all cases of refraction examined under a cycloplegic that came under my care from December, 1901, to December, 1903. The errors of refraction were estimated in the usual manner with trial lenses. The instrument used in making the corneal measurements was the ophthalmometer of Chambers, Inskeep &amp; Co. On the side of one of the recording wheels the curvature of the corneal meridians can be read off in millimeters. This instrument, so far as I know, is accurate. It does not measure corneal meridians whose radii of curvature are shorter than 6.85 mm., nor of those longer than 9.00 mm. Reference to Table 1 shows that out of 2,092 corneal meridians examined, 1,273 were hypermetropic in refraction, 507 myopic and 312 emmetropic. It was found that the instrument measured all corne that came under my observation, except one case of conical
Episcleritis and scleritis. Their association with connective tissue disease.
Authors: A J Lyne, D A Pitkeathly
Journal: Annals of the Rheumatic Diseases (1970)

Heberden Society 191 trabeculae with reduced bone modelling seems to be the most likely aetiology.According to the literature approximately 25 per cent. of the cases treated by early but prolonged non-weight- bearing (up to 4 years) appear to heal satisfactorily.In
Enteral nutrition with or without N-acetylcysteine in the treatment of severe acute alcoholic hepatitis: A randomized multicenter controlled trial
Authors: Christophe Moreno, Philippe Langlet, Axel Hittelet, Luc Lasser, Delphine Degré, Sylvie Evrard, Isabelle Colle, Arnaud Lemmers, Jacques Devière, Olivier Le Moine
Journal: Journal of Hepatology (2010)
Renal cyst growth is the main determinant for hypertension and concentrating deficit in Pkd1 -deficient mice
Authors: Jonathan M. Fonseca, Ana P. Bastos, Andressa G. Amaral, Mauri F. Sousa, Leandro E. Souza, Denise M. Malheiros, Klaus Piontek, Maria C. Irigoyen, Terry J. Watnick, Luiz F. Onuchic
Journal: Kidney International (2014)
Risk of preterm birth after treatment for cervical intraepithelial neoplasia among women attending colposcopy in England: retrospective-prospective cohort study
Authors: A. Castanon, P. Brocklehurst, H. Evans, D. Peebles, N. Singh, P. Walker, J. Patnick, P. Sasieni
Journal: BMJ (2012)

Receptor activity-modifying proteins (RAMPs) are single-transmembrane proteins that transport the calcitonin receptor-like receptor (CRLR) to the cell surface. RAMP 1-transported CRLR is a calcitonin gene-related peptide (CGRP) receptor. RAMP 2- or RAMP 3-transported CRLR is an adrenomedullin receptor. The role of RAMPs beyond their interaction with CRLR, a class II G protein-coupled receptor, is unclear. In this study, we have examined the role of RAMPs in generating amylin receptor phenotypes from the calcitonin (CT) receptor gene product. Cotransfection of RAMP 1 or RAMP 3 with the human CT receptor lacking the 16-amino acid insert in intracellular domain 1 (hCTR<sub>I1−</sub>) into COS-7 cells induced specific<sup>125</sup>I-labeled rat amylin binding. RAMP 2 or vector cotransfection did not cause significant increases in specific amylin binding. Competition-binding characterization of the RAMP-induced amylin receptors revealed two distinct phenotypes. The RAMP 1-derived amylin receptor demonstrated the highest affinity for salmon CT (IC<sub>50</sub>, 3.01 ± 1.44 × 10<sup>−10</sup> M), a high to moderate affinity for rat amylin (IC<sub>50</sub>, 7.86 ± 4.49 × 10<sup>−9</sup> M) and human CGRPα (IC<sub>50</sub>, 2.09 ± 1.63 × 10<sup>−8</sup> M), and a low affinity for human CT (IC<sub>50</sub>, 4.47 ± 0.78 × 10<sup>−7</sup> M). In contrast, whereas affinities for amylin and the CTs were similar for the RAMP 3-derived receptor, the efficacy of human CGRPα was markedly reduced (IC<sub>50</sub>, 1.12 ± 0.45 × 10<sup>−7</sup> M; <i>P</i> &lt; .05 versus RAMP 1). Functional cyclic AMP responses in COS-7 cells cotransfected with individual RAMPs and hCTR<sub>I1−</sub> were reflective of the phenotypes seen in competition for amylin binding. Confocal microscopic localization of c-myc-tagged RAMP 1 indicated that, when transfected alone, RAMP 1 almost exclusively was located intracellularly. Cotransfection with calcitonin receptor (CTR)<sub>I1−</sub> induced cell surface expression of RAMP 1. The results of experiments cross-linking <sup>125</sup>I-labeled amylin to RAMP 1/hCTR-transfected cells with bis succidimidyl suberate were suggestive of a cell-surface association of RAMP 1 and the receptors. Our data suggest that in the CT family of receptors, and potentially in other class II G protein-coupled receptors, the cellular phenotype is likely to be dynamic in regard to the level and combination of both the receptor and the RAMP proteins.
Regional Wall Motion and Abnormalities of Electrical Depolarization and Repolarization in Patients After Surgical Repair of Tetralogy of Fallot
Authors: Michael Vogel, Julia Sponring, Seamus Cullen, John E. Deanfield, Andrew N. Redington
Journal: Circulation (2001)

Abnormal depolarization-repolarization in patients with repaired tetralogy of Fallot (TOF) is a risk factor for malignant ventricular tachycardia and sudden death. It is unclear whether ECG abnormalities are associated with abnormal regional right ventricular (RV) function.Seventy-four patients (37 patients <18 and 37 >18 years old) who had had TOF repair at 4.0 years old (0.1 to 47 years old) were examined when they were 18.7 years old (1.7 to 61.1 years old), as were 112 control subjects with normal hearts. Regional function was evaluated with tissue Doppler imaging of the RV and left ventricular (LV) free wall and the septum. Myocardial velocities were sampled continuously from base to apex. Synchronous ECG was analyzed for QRS, QT, and JT duration and QRS, QT, and JT dispersion. All 74 TOF patients had normal LV myocardial velocities. Forty-eight patients (24 patients <18 and 24 >18 years old) had reversed myocardial velocities in diastole in the RV free wall, which were associated with reversed systolic myocardial velocities in 22 and additional reverse diastolic myocardial velocities in the septum in 19. Those 48 patients had a longer QRS duration (151+/-31 versus 124+/-27 ms) and greater QRS (47+/-18 versus 29+/-12 ms), QT (73+/-27 versus 52+/-22 ms), and JT (96+/-31 versus 67+/-35 ms) dispersion. Compared with normal control subjects, all 74 TOF patients had decreased systolic and diastolic myocardial velocities and a longer isovolumic relaxation time.RV wall-motion abnormalities are a common finding late after TOF repair and are associated with repolarization-depolarization abnormalities. These data further underscore a likely mechanoelectrical interaction as an important part of the pathogenesis of RV disease in these patients.
Idiopathic Thrombocytopenic Purpura
Authors: Mario Baldini
Journal: New England Journal of Medicine (1966)

A CHANGE in the concepts regarding idiopathic thrombocytopenic purpura has occurred during the past fifteen years mainly because of the recognition of three important facts: The thrombocytopenia is the result of increased platelet destruction. The old hypothesis, originally postulated by Frank,1 , 2 of a toxic depression of megakaryocytes and their activity resulting in thrombocytopenia has been disproved since a shortened platelet life-span has regularly been found in the disease. An antiplatelet factor with characteristics of an antibody is present in the plasma of these patients.3 In fact, normal donor platelets infused into the patient are destroyed as rapidly as . . .
A PLEA FOR UNIFICATION AND UNIFORM ORGANIZATION.
Authors: J. N. McCORMACK
Journal: JAMA (1904)

<i>To the Medical Profession of the State of New York:</i> After correspondence on the subject with members of the Joint Conference Committee and others, more especially on the society side, I have been requested, as chairman of the committee which has had this work in charge from its inception, to prepare for publication an explanation of the plan of organization for state and county societies which has been so generally adopted in the last two or three years. As the plan was prepared and is recommended for universal adoption, is already in satisfactory operation in 32 states and in over 1,500 counties, and is likely to be adopted in nearly all of the other states as soon as their annual meetings occur, as the subject is one of interest at this time to every member and well-wisher of our profession, and more especially as the preparation of the plan for
Blair must raise taxes to eradicate child poverty, academics say
Authors: W. Moore
Journal: BMJ (2000)

Prime Minister Blair has no alternative but to raise taxes if he is to reach his goal of eradicating child poverty in the United Kingdom within 20 years, a leading public health academic has warned.

The government has made a good start towards reducing poverty with a raft of welfare measures including those announced in last month's budget, said David Piachaud, professor of social policy at the London School of Economics. It is now necessary for the government not only to maintain action to achieve …
β-Adrenergic Augmentation of Flecainide-Induced Conduction Slowing in Canine Purkinje Fibers
Authors: Kevin T. Cragun, Susan B. Johnson, Douglas L. Packer
Journal: Circulation (1997)

Background This study was undertaken to test the hypothesis that β-adrenergic stimulation in the setting of membrane depolarization will potentiate flecainide-induced conduction slowing. Methods and Results To elucidate the potential mechanism for the flecainide proarrhythmia observed in CAST, the voltage dependence of β-adrenergic modulation of impulse propagation in eight flecainide-superfused canine Purkinje fibers was examined with a dual-microelectrode technique. At physiological membrane potentials (V m ) ([K + ] o =5.4 μmol), 1 μmol flecainide decreased V̇ max from 698±55 to 610±72 V/s ( P =.003) and squared conduction velocity (θ 2 ) from 2.11±1.1 to 1.72±0.9 (m/s) 2 ( P =.001). With K + depolarization to V m =−70 mV, flecainide further reduced V̇ max from 306±101 to 245±65 V/s and θ 2 from 1.12±0.4 to 0.99±0.6 (m/s) 2 , producing a 2.0-mV hyperpolarizing shift of apparent Na + channel availability curves derived from θ 2 . The addition of 1 μmol isoproterenol to flecainide-superfused fibers at physiological V m increased θ 2 by 8% to 1.84±0.6 (m/s) 2 ( P &lt;.01) without altering V̇ max . At −70 mV, the addition of isoproterenol magnified the flecainide-induced reduction of V̇ max an additional 24% to 185±52 V/s ( P &lt;.01) and θ 2 by 17% to 0.82±0.5 (m/s) 2 ( P =.04), producing an additional 1.8-mV ( P =.002) and 1.9-mV ( P =.002) hyperpolarizing shift in the apparent Na + channel inactivation curves generated from V̇ max and θ 2 , respectively. At physiological V m , the action potential duration (APD 95 ) was reduced from 307±35 to 269±27 ms ( P &lt;.001) by flecainide and subsequently to 217±4 ms ( P &lt;.001) with isoproterenol addition. With 12 mmol/L K + , APD 95 decreased from 198±23 to 182±17 ms ( P =.005) with flecainide and to 164±10 ms ( P =.004) with isoproterenol. Conclusions At depolarized V m , isoproterenol amplified the flecainide-induced reduction of V̇ max and θ 2 , suggesting a further adrenergic-mediated reduction of Na + current. Consequently, the synergy between catecholamines and flecainide at depolarized V m and the shortened APD 95 could facilitate arrhythmogenesis in the presence of underlying ischemia.
Exaggerated Systolic Blood Pressure During Treadmill Test in Pre-Hypertensive Patients with Dilatation of Ascending Aorta
Authors: Mustafa Aparci, Murat Yalcin, Zafer Isilak, Zekeriya Arslan, Omer Uz, Cengiz Ozturk, Ejder Kardesoglu
Journal: Journal of the American College of Cardiology (2013)