tbuckley/cabot-search huggingface dataset:
Inhibition of miR-182 decreases OVA-induced arthritis in mice
Authors: A.-B. Stittrich, C. Haftmann, E. Sgouroudis, Z. Fang, N. Rajewsky, H.-D. Chang, A. Radbruch, M.-F. Mashreghi
Journal: Annals of the Rheumatic Diseases (2011)

<h3>Background and objectives</h3> After antigenic stimulation, T helper lymphocytes have to expand clonally in order to generate a large pool of specific effector cells. This process is positively regulated by the interleukin-2 induced microRNA-182 (miR-182), which inhibits the expression of the forkhead transcription factor Foxo1, a suppressor of T helper cell proliferation. Specific inhibition of miR-182 in T helper cells limits their expansion in vitro and in vivo. Therefore, the authors examined whether specific inhibition of miR-182 by antagomirs affects the ability of T helper cells to induce inflammation in a mouse model of OVA-induced arthritis. <h3>Material and methods</h3> The authors treated OVA-specific T helper lymphocytes from DO11.10 mice with antagomir-182 ex vivo and transferred them adoptively into Balb/c mice. One day after transfer the authors immunised with OVA. On day 14 after transfer, the authors injected OVA into the left knee joint and assessed knee swelling as a sign of inflammation. Knee joints were processed for histological examination. <h3>Results</h3> Knee swelling was about 40% less after transfer of antagomir-182-treated T helper cells. Knockdown of miR-182 with antagomirs resulted in significantly lower histological scores for inflammation and tissue destruction. Infiltration of granulocytes and mononuclear cells into the inflamed tissue of the knee joint, as well as bone and cartilage destruction and the formation of pannus tissues, were lower in the mice given antagomir-182-treated cells than in the control group. <h3>Conclusions</h3> The results showing less disease severity in a transfer model of OVA-induced arthritis open a new therapeutic avenue for the control of unwanted T helper cell expansion in immune-mediated diseases by antagomirs.
Hypercalcemia, Hodgkin's Disease, and Calcitriol
Authors: MARK A. NEEDLE
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 June 1984Hypercalcemia, Hodgkin's Disease, and CalcitriolMARK A. NEEDLE, M.D., B. CHANDRA, M.D.MARK A. NEEDLE, M.D.Search for more papers by this author, B. CHANDRA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-6-916_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the recent report by Breslau and associates (1). We have recently studied the case of a patient with Hodgkin's disease with hypercalcemia and increased calcitriol levels.A 51-year-old white man was admitted to St. Joseph's Hospital and Medical Center with polyuria, polydyspia, and constipation. The only abnormal findings on physical examination were hard 1- to 2-cm left inguinal lymphadenopathy and a spleen tip palpable on deep inspiration. Laboratory data included serum calcium, 11.7 mg/dL; inorganic phosphorus, 2.1 mg/dL; creatinine, 2.9 mg/dL; albumin, 4.3 mg/dL; magnesium, 2.1 mg/dL; and alkaline phosphatase, 0.52 IU/L. Thyroid...Reference1. BRESLAU N, MCGUIRE J, ZERWEKH J, FRENKEL E, and PARK C. Hypercalcemia associated with increased serum calcitriol levels, in three patients with lymphoma. Ann Intern Med. 1984;100:1-7. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARK A. NEEDLE, M.D.; B. CHANDRA, M.D.Affiliations: St. Joseph's Hospital and Medical Center Paterson, NJ 07503 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCase 207: Hodgkin Lymphoma with Paraneoplastic Hypercalcemic PancreatitisHypercalcémie majeure révélatrice d'une sarcoïdose1,25-Dihydroxyvitamin D-related hypercalcemia in lymphoma: Two case reportsHypercalcemia and vitamin d metabolism in Hodgkin's disease. Is there an underlying immunoregulatory relationship?Humoral hypercalcemia in Hodgkin's disease. Clinical and laboratory evaluationRecurrent hypercalcemia and elevated 1,25-dihydroxyvitamin D levels in hodgkin's diseaseCase Report: Granuloma-Related Hypercalcemia in Lipoid PneumoniaLymphoma, Hypercalcemia, and Serum Calcitriol LevelsCHIKASHI KITOH, M.D. 1 June 1984Volume 100, Issue 6Page: 916-916KeywordsCalcitriolHodgkin lymphomaHypercalcemiaMagnesiumPhosphatasesPhosphorusResearch laboratoriesSerum albuminSpleenThyroid ePublished: 1 December 2008 Issue Published: 1 June 1984 PDF downloadLoading ...
OSTEOMA CUTIS AND ALBRIGHT'S HEREDITARY OSTEODYSTROPHY
Authors: C. G. D. BROOK, H. B. VALMAN
Journal: British Journal of Dermatology (1971)

Summary.— A child with osteoma cutis is reported who was shown to have pseudo‐pseudohypoparathyroidism(PPH). Investigation of the family revealed subcutaneous calcification in the brother and mother, who were shown respectively to have pseudohypoparathyroidism (PH) and PPH, variants of Albright's hereditary osteodystrophy (AHO). Review of the literature suggests that most of the cases of ‚primary’ osteoma cutis are examples of AHO.
Resolution of paraneoplastic bile duct paucity following successful treatment of Hodgkin's disease
Authors: O M Crosbie, J P Crown, N P Nolan, R Murray, J E Hegarty
Journal: Hepatology (1997)

We report the case of a 21-year-old woman who developed severe adult onset ductopenia in association with Hodgkin's lymphoma. Chemotherapy resulted in a remission of her Hodgkin's disease (HD) and significant improvement in liver function with resolution of the hepatic and biliary duct histological abnormalities, a therapeutic success not previously described in the literature.
Unusual increase in reported cases of Paratyphoid A fever among travellers returning from Cambodia, January to September 2013
Authors: M Tourdjman, S Le Hello, C Gossner, G Delmas, S Tubiana, L Fabre, A Kerléguer, A Tarantola, A Fruth, I Friesema, L Thorstensen Brandal, J Lawrence, I Fisher, M Dufour, F  X Weill, H de Valk
Journal: Eurosurveillance (2013)

From January to September 2013, a marked increase in notifications of Salmonella Paratyphi A infections among travellers returning from Cambodia occurred in France. An investigation revealed 35 cases without a common source: 21 in France, five in Germany, three in the Netherlands, one in Norway, one in the United Kingdom, four in New-Zealand. Data suggest an ongoing event that should trigger further investigation. Travellers to Cambodia should observe preventive measures including good personal hygiene and food handling practices.
Genetics, Epigenetics, and Leukemia
Authors: Kevin Shannon, Scott A. Armstrong
Journal: New England Journal of Medicine (2010)

In this issue of the Journal, Ley and colleagues1 report that somatic mutations in a gene encoding a DNA methyltransferase, DNMT3A, are common in adults with acute myeloid leukemia (AML). They also report that these mutations are associated with discrete molecular and cytogenetic features that have prognostic significance. These findings have implications for clinical investigators, for researchers working to characterize the molecular mechanisms that contribute to leukemic growth, and, more broadly, for illuminating mechanisms of epigenetic reprogramming in cancer cells.Ley et al. sequenced the genome of leukemia cells from a patient with AML and observed a DNMT3A mutation. They . . .
Effect of Intravenous Infusions of Ethanol upon Estimated Hepatic Blood Flow in Man1
Authors: Albert I. Mendeloff
Journal: Journal of Clinical Investigation (1954)

During the course of studies concerning the utilization by the human liver of parenteral feeding solutions containing ethanol, it was observed that these infusions resulted consistently in changes in the estimated hepatic blood flow. The amount of ethanol infused into these human subjects produced blood ethanol concentrations far below those known to be intoxicating ( 1 ), and lower than those levels reported to achieve some degree of postoperative sedation (2). Since even massive ethanol dosage is reportedly without effect on mammalian hemodynamics (3), it seemed unlikely that the changes in estimated hepatic blood flow observed here were due to gross changes in the circulation. This report demonstrates that the infusion of small amounts of ethanol in saline into unanesthetized adult human subjects produces consistently significant increases in estimated hepatic blood flow, most probably as a result of a specific decrease in splanchnic peripheral resistance.
Increasing Viral Burden in CD4+ T Cells from Patients with Human Immunodeficiency Virus (HIV) Infection Reflects Rapidly Progressive Immunosuppression and Clinical Disease
Authors: Steven M. Schnittman
Journal: Annals of Internal Medicine (1990)

Objective: To determine over time the relation between viral burden and immunologic decline in patients with asymptomatic human immunodeficiency virus (HIV) infection. Design: Blind analysis of cell samples from matched cohorts for HIV proviral DNA by polymerase chain reaction, retrospective analysis of clinical data on patients, and prospective follow-up of patients seropositive for the human immunodeficiency virus type 1 (HIV-I). Setting: National research clinic and academic medical centers. Patients: Cohort 1 included 12 healthy HIV-1-seropositive patients (average follow-up, 14 months): Six patients had stable disease and 6 developed rapidly progressive disease. Cohort 2 included 15 healthy HIV-1-seropositive patients from the Multicenter AIDS Cohort Study (average follow-up, 32 months): Eight patients had stable disease and 7 developed rapidly progressive disease. Laboratory Studies: Quantitative polymerase chain reaction was done to determine the HIV-I viral burden in sort-purified CD4+ T cells obtained from patients at various timepoints. Measurements and Main Results: In patients who remained asymptomatic, frequencies of HIV-infected CD4+ T cells were low (< 1/10 000 to 1/1000) at study entry and increased only minimally (none higher than 1/1000). In contrast, among patients who developed HIV-related symptoms including the acquired immunodeficiency syndrome (AIDS) despite having similar CD4 counts, frequencies of HIV-infected CD4+ T cells were higher at entry (> 1/1000) and increased substantially (> 1/100) in most within 3 months of developing progressive disease. This increase in HIV burden coincided with a significant decline over time in the percent of T4 cells (31% to 16%), whereas the percent of T4 cells was unchanged in persons who remained asymptomatic (33% to 34%). Conclusions: Increasing viral burden in peripheral blood CD4+ T-cells is directly associated with a progressive decline in CD4+ T cells and deteriorating clinical course in HIV-infected patients.
Vegetative Plaques and Hemorrhagic Pustules
Authors: Robert Stavert, Christopher G. Bunick, Badri Modi, Deanne Mraz Robinson, Omer Ibrahim, Eleanor Knopp, Robert Tigelaar, Suguru Imaeda
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
102 Sphingosine-1-phosphate triggers wound healing via the S1P2 receptor following acute liver injury
Authors: V. Serriere-Lanneau, F. Teixeira-Clerc, M. Schippers, W. de Vries, B. Julien, J. Tran-Van-Nhieu, K. Poelstra, J. Chun, A. Mallat, S. Lotersztajn
Journal: Journal of Hepatology (2006)
Alcohol as a Food.
Authors: H. I. Winn
Journal: JAMA (1900)

Clarendon, Texas, June 13, 1900. <h3>To the Editor:</h3> —I am surprised to see in<i>The Dallas News</i>, an editorial which quotesThe Journal, and other medical journals, as authority for the statement "that alcohol can not by any scientific evidence be called a food." I supposed that all scientific medical men of this day had long since accepted as a fact established, and no longer<i>sub judice</i>, that alcohol up to a certain amount was consumed and utilized as food. I am therefore exceedingly surprised to see a reputable medical journal discuss the subject at all, and, of course, much more so to find it lending its influence to the propagation of false teaching. I have at hand the latest and most authoritative teachings on the subject which agree fully with my observation and experience that, in the language of one of these authorities—Thompson—"In many cases of malnutrition, and malassimilation
Effect of Laser Prostatectomy on the Serum Prostate-Specific Antigen Concentration: Results of a Prospective Study
Authors: Alim Ko&scedil;ar, Kemal Sarica, Erol &Ouml;zd&iacute;ler, Mehmet Budak, &Ccedil;etin D&iacute;n&ccedil;el, Orhan G&ouml;&gcaron;&uuml;&scedil;
Journal: European Urology (1998)
Recent advances in the management of rheumatoid arthritis
Authors: N. B. Klarenbeek, P. J. S. M. Kerstens, T. W. J. Huizinga, B. A. C. Dijkmans, C. F. Allaart
Journal: BMJ (2010)

#### Summary points

Until the 1990s patients with rheumatoid arthritis were initially treated with aspirin or other non-steroidal anti-inflammatory drugs; disease modifying anti-rheumatic drugs (DMARDs), such as methotrexate, were introduced only as the disease progressed. Combined treatment with more than one DMARD was reserved for patients with the most severe disease. The outcome for most patients was functional deterioration with progressive damage. However, innovations in drugs, better tools for monitoring treatment, and tight control strategies have improved the outlook for patients with rheumatoid arthritis. Remission with limited radiological damage and no functional deterioration is now a realistic treatment goal. Several randomised controlled trials have shown that treatment with DMARDs, corticosteroids, and biological agents early in the course of disease can retard progression of disease, reduce joint destruction, and improve functional ability and health related quality of life. This, along with the introduction of new tools to monitor response to treatment, has led to a new treatment approach and improved outcomes.1 We review evidence from randomised trials, systematic reviews, and recently published guidelines and outline the new approach to treatment, emphasising the importance of early diagnosis, referral, and treatment.

#### Sources and selection criteria

We used recently published recommendations on the treatment of rheumatoid arthritis. We also searched the Cochrane Database of Systematic Reviews (without time …
Is the postphlebitic leg always postphlebitic? Relation between phlebographic appearances of deep-vein thrombosis and late sequelae.
Authors: N L Browse, G Clemenson, M L Thomas
Journal: BMJ (1980)

One hundred and thirty legs of 67 patients were examined 5-10 years after the patient had suffered a phlebographically proved deep-vein thrombosis. Forty-seven of the limbs were normal at the time of the phlebogram, 83 contained thrombus. There was little correlation between the phlebographic severity of the thrombus and the late symptoms and signs: 32% of the legs with no thrombosis had symptoms, while 33% of the legs which had suffered severe thrombosis had no symptoms. Postphlebitic symptoms were more common in legs with aging thrombus at the time of phlebography, but upper limit of the thrombus, the age of the patient, and preexisting symptoms did not affect the incidence of late sequelae. The development of a "postphlebitic leg" does not depend solely on the extent of the initial thrombosis and can apparently develop in the absence of thrombosis.
Laparoscopic versus percutaneous liver biopsy (LB) in HIV patients with fever of undetermined origin (FUO) and/or cholestasis. A randomized, controlled study
Authors: Eduardo Fassio, Carlos Varsky, Cristina Longo, Estela Alvarez, Graciela Peluffo, Alejandro Dutack, Graciela Landeira, Nora Dominguez
Journal: Journal of Hepatology (2001)
CASES OF PENETRATING STAB WOUNDS OF THE ABDOMEN; LAPAROTOMY; RESULTS.Read at the Meeting of the Mississippi Valley Medical Association, at Louisville, Ky., October 9, 1890.
Authors: H. C. DALTON
Journal: JAMA (1890)

I report to-day six cases of laparotomy for penetrating stab wounds of the abdomen in which the viscera were injured, one death and five recoveries. <i>Case 1. Wound of Descending Colon and Ileum; Laparotomy; Recovery</i>.—Edward T., colored, æt. 16, was admitted to the City Hospital July 23, 1890. Two hours previous he was stabbed with a long, narrow-bladed "chicken knife." The wound of entrance was quite small and situated in the left iliac region, near the free extremity of the twelfth rib. Two inches of omentum protruded. The patient's general condition was excellent; there was but little pain; pulse 62, respiration 23, rectal temperature 100° F. Percussion gave dulness in the left lumbar and iliac regions. The liver dulness was greatly diminished. After thorough antiseptic precautions, an incision 4 inches long was made in the left linea semilunaris. Considerable blood and faecal matter were found in the cavity. There were
Comparative Impact of Trastuzumab and Cyclophosphamide on HER-2–Positive Human Breast Cancer Xenografts
Authors: Giulio Francia, Shan Man, Chyan-Jang Lee, Christina R. Lee, Ping Xu, Miriam E. Mossoba, Urban Emmenegger, Jeffrey A. Medin, Robert S. Kerbel
Journal: Clinical Cancer Research (2009)

Abstract Purpose: Metronomic chemotherapy is a minimally toxic and frequently effective new treatment strategy that is beginning to show promising phase II clinical trial results, particularly for metastatic breast cancer when combined with various molecularly targeted antitumor agents. Here, we assessed a treatment strategy that uses trastuzumab plus daily oral metronomic cyclophosphamide on metastatic Her-2–positive human breast cancer models. Experimental Design: Treatments were initiated on orthotopic transplanted primary tumors as well as established visceral metastatic disease of two independent Her-2–positive breast cancer models, both independently derived from the human MDA-MB-231 breast cancer cell line. Outcome was assessed by noninvasive measurements of tumor cell–secreted human choriogonadotropin in the urine as a surrogate marker of relative tumor burden, or by whole body bioluminescent imaging, in addition to prolongation of survival. Results: Orthotopic primary tumors responded to trastuzumab monotherapy with significant growth delays, whereas minimal antitumor effect was observed when mice with metastatic disease were treated. Nevertheless, trastuzumab showed a benefit in this latter setting when combined with metronomic low-dose cyclophosphamide as assessed by prolongation of survival. This benefit was similar to trastuzumab plus maximum tolerated dose cyclophosphamide, but was associated with lesser toxicity. Conclusions: Trastuzumab combined with metronomic cyclophosphamide may be an effective long-term maintenance strategy for the treatment of Her-2–positive metastatic breast cancer. (Clin Cancer Res 2009;15(20):6358–66)
Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations
Authors: Nisha Limaye, Vinciane Wouters, Melanie Uebelhoer, Marjut Tuominen, Riikka Wirkkala, John B Mulliken, Lauri Eklund, Laurence M Boon, Miikka Vikkula
Journal: Nature Genetics (2008)
Endoscopic retrograde cholangiopancreatography
Authors: G. Ginsberg
Journal: Endoscopy (2007)

Endoscopic retrograde cholangiopancreatography (ERCP) is pivotal in the diagnosis and management of pancreaticobiliary disorders. At the same time it is one of the most sophisticated and challenging techniques in our endoscopic armamentarium. This article reviews some of the highlights of the ERCP-related research presented at this year’s Digestive Disease Week. Clinical investigation was aimed at enhancing efficacy, improving safety, and expanding the applications of ERCP. The most compelling themes addressed new techniques and new technologies applied to new and old problems. The overall impression is that while the quantity of ERCP-related research might be diminishing over the years, the quality is growing.
The colon and PSC: new liver, new danger?
Authors: R W CHAPMAN
Journal: Gut (1998)

See article on page 639 

The close relation between primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) continues to provide more questions than answers. The prevalence of IBD in patients with PSC is about 55–75%, and PSC occurs in patients with ulcerative colitis at a frequency of 2.5–7.5%.1 2 PSC is found less often in Crohn’s disease where it is usually associated with colonic involvement. Recent studies have found an increased prevalence of colonic dysplasia and cancer in patients with PSC and ulcerative colitis compared with ulcerative colitis alone.3 4 The mechanism by which PSC increases the risk of colonic neoplasia is unknown. The increased long term survival of patients with both PSC and ulcerative colitis after liver transplantation may therefore put these patients at an increased risk of developing colorectal cancer in view of the increased neoplastic potential as a result of the immunosuppressive therapy required after liver transplantation. Indeed, some studies have suggested that there may be a higher incidence of colorectal cancer in the first two years after liver transplantation.5-7 This may reflect the higher doses of immunosuppression …