tbuckley/cabot-search huggingface dataset:
Alexithymia and Chronic Pain: Prevalence, Correlates and Treatment Results
Authors: George Mendelson
Journal: Psychotherapy and Psychosomatics (1982)

The alexithymia scale of the Minnesota Multiphasic Personality Inventory was used to determine the prevalence of alexithymia in a group of 60 patients attending a chronic pain clinic. It was found that 28 patients (47%) obtained scores in the 'alexithymic' range. The alexithymic patients had a significantly longer history of pain, but were not significantly older than the nonalexithymic group. Alexithymic patients showed significantly lower neuroticism, hypochondriasis, affective disturbance, and irritability scores. In a pilot study two subgroups of 15 alexithymic and 15 non-alexithymic patients were compared following a period of treatment; in both groups equal proportions of patients showed significant pain relief. Although this study does not support the view that alexithymia is of significance in the psychomaintenance of chronic pain, it is suggested that clinicians working with chronic pain patients should be familiar with the concept of alexithymia.
Sarcoidosis of the Spleen
Authors: Odell C. Kimbrell
Journal: New England Journal of Medicine (1957)

SINCE Boeck's1 description of the disease in 1899, many excellent articles have been written about sarcoidosis.2 3 4 5 6 7 8 9 10 11 12 13 Sarcoid lesions have been identified in nearly all organs of the body. Chiefly involved are the lungs, lymph nodes, spleen and liver. Less commonly, lesions have been noted in the gastrointestinal tract, adrenal glands, uterus and ovaries. Sarcoid may occur as scattered isolated lesions or may completely replace the normal structure of the part involved.6 , 9 , 14 15 16 Involvement of the spleen may lead to anatomic and functional complications. The former include spontaneous rupture and abdominal discomfort due to increased splenic size; the functional complication is hypersplenism. . . .
Differential diagnosis of cystic tumors of the pancreas by endoscopic ultrasonography
Authors: H. Kubo, K. Nakamura, S. Itaba, S. Yoshinaga, N. Kinukawa, Y. Sadamoto, T. Ito, H. Yonemasu, R. Takayanagi
Journal: Endoscopy (2009)

Background and study aims: Generally, cystic tumors are divided into two categories: neoplastic cystic tumors and non-neoplastic cystic (NNC) tumors. Neoplastic cystic tumors include mucinous cystic neoplasm (MCN), intraductal papillary-mucinous neoplasm (IPMN), and serous cystic neoplasm (SCN). MCNs and IPMNs have the potential to progress to a malignant state, whereas SCNs are known for their almost benign behavior. Thus, in order to make management decisions, it is important to distinguish between potentially malignant (MCN and IPMN), and benign (SCN and NNC) tumors. The aim of this study was to retrospectively investigate the value of endoscopic ultrasonography (EUS) for the differential diagnosis of cystic tumors of the pancreas.
TCT-557 IVUS Echogenicity Analysis of the Paclitaxel-Eluting Absorbable Magnesium Scaffold (DREAMS)
Authors: Michael Haude, Nico Bruining, Raimund Erbel, Paul Erne, Stefan Verheye, Paul Vermeersch, Hubertus Degen, Dirk Boese, Ron Waksman, Jacques Koolen
Journal: Journal of the American College of Cardiology (2013)
Tiotropium plus beclomethasone was more effective than doubling beclomethasone for asthma
Authors: Jaspal Singh
Journal: Annals of Internal Medicine (2011)

ACP Journal Club15 February 2011Tiotropium plus beclomethasone was more effective than doubling beclomethasone for asthmaJaspal Singh, MD, MHS, MHA, FCCPJaspal Singh, MD, MHS, MHA, FCCPCarolinas Medical Center, Charlotte, North Carolina, USA (J.S.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-4-201102150-02004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationPeters SP, Kunselman SJ, Icitovic N, et al. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med. 2010;363:1715-26. https://pubmed.ncbi.nlm.nih.gov/20979471Clinical Impact RatingsGIM/FP/GP: Allerg & Immunol: Pulmonology: References1 National Asthma Education and Prevention Program. Expert Panel Report III: guidelines for the diagnosis and management of asthma. Bethesda: National Institutes of Health. Report No: NIH 085846 2007. www.nhlbi.nih.gov/guidelines/asthma/asthsumm.pdf (accessed 5 Jan 2011). Google Scholar2 Stempel DA, Stoloff SW, Carranza Rosenzweig JR, et al. Adherence to asthma controller medication regimens. Respir Med. 2005;99:1263-7. [PMID: 16140227] Google Scholar3 Salpeter SR, Ormiston TM, Salpeter EE. Cardiovascular effects of beta-agonists in patients with asthma and COPD: a meta-analysis. Chest. 2004;125:2309-21. [PMID: 15189956] Google Scholar4 Welte T, Miravitlles M, Hernandez P, et al. Efficacy and tolerability of budesonide/formoterol added to tiotropium in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2009;180:741-50. [PMID: 19644045] Google Scholar Author, Article, and Disclosure InformationAffiliations: Carolinas Medical Center, Charlotte, North Carolina, USA (J.S.)This article was published at Annals.org on 1 February 2011. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 2011Volume 154, Issue 4Page: JC2-4KeywordsAsthmaLungsQuality of lifeQuestionnairesRespiratory system proceduresSafetySafety studiesTalcTreatment guidelines ePublished: 15 February 2011 Issue Published: 15 February 2011 CopyrightCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
A papular eruption associated with human T cell lymphotropic virus type III disease
Authors: William D. James, Robert R. Redfield, George P. Lupton, Monte S. Meltzer, Timothy G. Berger, O.G. Rodman, Phillip D. Markham, M.G. Sarngadharan, Syed Z. Salahuddin, Robert C. Gallo
Journal: Journal of the American Academy of Dermatology (1985)
Affinity of IgG-Insulin Antibodies to Human (recombinant DNA) Insulin and Porcine Insulin in Insulin-treated Diabetic Individuals With and Without Insulin Resistance
Authors: Guntram Schernthaner
Journal: Diabetes Care (1982)

The affinity of human (recombinant DNA) insulin and porcine insulin to preformed IgG-insulin antibodies of insulin-treated diabetic individuals was studied in 29 insulin-treated diabetic patients. The binding of 125I-human insulin and 125I-porcine insulin with antibodies was similar in the group of patients without insulin resistance (N = 25). The sera of insulin-resistant diabetic patients (N = 4), containing very high IgG-insulin immunoglobulins, showed a significantly lower affinity for human insulin compared with porcine insulin (P less than 0.01). All four patients with insulin-antibody-mediated insulin resistance were positive for HLA-DR4, but negative for -DR3, supporting the concept of an immunogenetically transferred anti-insulin immune response in insulin-treated diabetic individuals. Based on the reduced binding of human insulin to IgG-antibodies of very high titers in patients with insulin resistance, a potential therapeutic advantage of human insulin therapy can be expected in such infrequent cases of immunologic insulin resistance.
Case of Epilepsy of Six Years' Duration. Complete Recovery after Surgical Operation on the Skull and Brain
Authors: A. H. Bennett, A. P. Gould
Journal: BMJ (1887)

and probably all cases included under that name were examples of alcoholic paralysis.Periplheral neuritis was not a distinct disease, but a substratum underlying the symptoms of several very different affections.Professor BLovN.SIiQUARD considered that the effect of vaso-motor influences in producing tissue-change was unduly exaggerated.He pointed out the necessity of remembering all the causes which ope- rated in this direction: (1) changes in the chemical constitution of the part; (2) the blood-attracting inlluence of local tissue-change (3) the temporary suspension of the ordinary relations between the blood and the tissues.Under some circumstances of injury, etc., the blood in the veins came to resembla that in the arteries.All these conditions were produced through the influence of the nervous system.Dr. HYLA GREVES described the pathological changes found in two cases of alcoholic paraplegia occurring in the Liverpool Royal Infirmary, under the care of Dr. Glynn.In the first case, a woman aged 48, who had drunk largely of brandy for some time, had suffered from delirium trci nes.When admitted, she was greatly emaciated, and had a large bed-sore over the sacrum.The nervous symptoms were paresis ot the lower extremities, loss of knee-jerk, pain on pres- sure of muscles, cutaneous anesthesia and analgesia, burning pains in the soles of the feet.She dlied from septiciemia following septic ab- sorption from the bed-sore.On post mortem examination of the nervous system, the followinig changes were found.In the spinal cord, there was distiniet ascending degeneratioln in the cervical region.
MEDIS: A New Strategic Option for Acquiring Medical Information— Electronically
Authors: Daniel K. Harris
Journal: JAMA (1985)

In the genre of electronic data-base technology, MEDIS represents a full-text data-base service. In the case of<i>JAMA</i>, for example, the entire editorial content from 1982 to the present will be stored electronically. Subscribers to MEDIS, using most conventional data terminals, microcomputers, or a specially designed Mead terminal, are now able to search the entire body of knowledge contained in<i>JAMA</i>, not simply the citation or author abstract of refereed contributions. Add to this the full editorial content of the other nine AMA scientific publications, and the full text of over 50 additional medical journals, textbooks, and newsletters... and the power of MEDIS comes into focus. In considering the diffusion of ideas within the structure of medicine, Dr Donald A. B. Lindberg notes: "Ideas appear to move relatively rapidly through both the scientific and medical communities. Writings on this subject tend to lament only that there are not means to
Lactic Acid Is Elevated in Idiopathic Pulmonary Fibrosis and Induces Myofibroblast Differentiation via pH-Dependent Activation of Transforming Growth Factor-β
Authors: Robert Matthew Kottmann, Ajit A. Kulkarni, Katie A. Smolnycki, Elizabeth Lyda, Thinesh Dahanayake, Rami Salibi, Sylvie Honnons, Carolyn Jones, Nancy G. Isern, Jian Z. Hu, Steven D. Nathan, Geraldine Grant, Richard P. Phipps, Patricia J. Sime
Journal: American Journal of Respiratory and Critical Care Medicine (2012)

Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex disease for which the pathogenesis is poorly understood. In this study, we identified lactic acid as a metabolite that is elevated in the lung tissue of patients with IPF.Objectives: This study examines the effect of lactic acid on myofibroblast differentiation and pulmonary fibrosis.Methods: We used metabolomic analysis to examine cellular metabolism in lung tissue from patients with IPF and determined the effects of lactic acid and lactate dehydrogenase-5 (LDH5) overexpression on myofibroblast differentiation and transforming growth factor (TGF)-β activation in vitro.Measurements and Main Results: Lactic acid concentrations from healthy and IPF lung tissue were determined by nuclear magnetic resonance spectroscopy; α-smooth muscle actin, calponin, and LDH5 expression were assessed by Western blot of cell culture lysates. Lactic acid and LDH5 were significantly elevated in IPF lung tissue compared with controls. Physiologic concentrations of lactic acid induced myofibroblast differentiation via activation of TGF-β. TGF-β induced expression of LDH5 via hypoxia-inducible factor 1α (HIF1α). Importantly, overexpression of both HIF1α and LDH5 in human lung fibroblasts induced myofibroblast differentiation and synergized with low-dose TGF-β to induce differentiation. Furthermore, inhibition of both HIF1α and LDH5 inhibited TGF-β–induced myofibroblast differentiation.Conclusions: We have identified the metabolite lactic acid as an important mediator of myofibroblast differentiation via a pH-dependent activation of TGF-β. We propose that the metabolic milieu of the lung, and potentially other tissues, is an important driving force behind myofibroblast differentiation and potentially the initiation and progression of fibrotic disorders.
Therapeutic patient education in atopic eczema
Authors: S. Barbarot, J.F. Stalder
Journal: British Journal of Dermatology (2014)

Therapeutic patient education (TPE) is a patient-centred process that entails the transfer of skills (e.g. self-management, treatment adaptation) from a trained healthcare professional to patients and/or their carers. TPE has been shown to help improve adherence, prevent complications, and improve quality of life (QoL) in chronic illnesses such as diabetes, asthma and cardiovascular disease. Recently, TPE recommendations for patients with atopic eczema have been proposed. TPE is a four-step process: understanding the patient's knowledge, beliefs and hopes; setting age-appropriate educational objectives; helping the patient (or carer) to acquire skills; and assessing the success of the programme. TPE programmes always involve a multidisciplinary team of healthcare professionals, including nurses, psychologists, doctors and dieticians who are expert in the disease area. TPE should be offered to (never forced upon) any patient who has experienced treatment failure, or to families who feel they lack social support. High-quality TPE programmes should be evidence-based, tailored to a patient's individual educational and cultural background (rather than being standardized in form and content), and have well-defined content and activities.
Lower Extremity Schwannoma: F-18 FDG PET and MR Demonstration
Authors: Ba D. Nguyen
Journal: Clinical Nuclear Medicine (2005)

PET imaging with F-18 FDG is valuable in the staging of melanomas with helpful demonstration of high metabolic locoregional and distant metastases of this neoplasm. Dissemination of melanoma may be falsely diagnosed in the concomitant existence of benign soft tissue lesions taking up F-18 FDG as shown in the two following cases of lower extremity schwannomas. Epidemiology and imaging characteristics of schwannomas are briefly reviewed and discussed.
The Family History — More Important Than Ever
Authors: Alan E. Guttmacher, Francis S. Collins, Richard H. Carmona
Journal: New England Journal of Medicine (2004)

Although the family history is part of the basic workup that has been taught in medical schools for generations, it often does not get the attention it should. In this article, the authors make the case for taking a good family history in the era of genomic medicine and provide a computer tool that can be downloaded and used by patients to help record this history.
Long-Term Outcome of Isolated Coronary Artery Bypass Surgery in Patients With Severe Left Ventricular Dysfunction
Authors: Jehangir Appoo, Colleen Norris, Sabrina Merali, Michelle M. Graham, Arvind Koshal, Merril L. Knudtson, William A. Ghali
Journal: Circulation (2004)

Background— Coronary artery bypass grafting (CABG) is indicated in patients with coronary artery disease and impaired ventricular function. However, earlier studies have suggested that prognosis of patients with severe left ventricular dysfunction is extremely poor. We used the APPROACH registry to derive contemporary estimates of prognosis associated with CABG for this high-risk patient population. Methods and Results— The study group consisted of 7841 patients who had isolated CABG in the province of Alberta, Canada between 1996 and 2001. Patients with markedly reduced left ventricular function (ejection fraction [EF] &lt;30%, Lo EF, n =430) were compared with those with moderate reduction in ventricular function (EF 30% to 50%, Med EF, n =2581) and those with normal left ventricular function (EF &gt;50%, normal [Nl] EF, n=4830). The operative mortality was higher in the patient group with Lo EF (4.6%) compared with Med EF and Nl EF groups (3.4% and 1.9%, respectively, P &lt;0.001). At 5 years, survival was 77.7% for Lo EF patients compared with 85.5% and 91.2% for Med EF and Nl EF patients, respectively ( P &lt;0.001). After controlling for other independent variables, the adjusted hazard ratio for death was 1.98 (95% CI, 1.49 to 2.62) for Lo EF relative to Nl EF. The mortality rate at 1 year was significantly lower for Lo EF patients who underwent CABG than it was for nonrevascularized Lo EF patients (risk-adjusted odds ratio, 0.36; 95% CI, 0.24 to 0.55). Conclusions— In the modern era of cardiac surgery, CABG can be performed in Lo EF cases with an acceptable perioperative mortality risk. Our estimate of 5-year survival in this high-risk group is better than previously reported in the literature from earlier periods.
Imaging inflammation in atherosclerotic lesions by radiolabeled chemotactic peptide: Would identification of vulnerable plaques become feasible?
Authors: Artiom Petrov, Dagmar Hartung, Frank Kolodgie, Navneet Narula, Nezam Haider, Andrew Kohut, Renu Virmani, Jagat Narula
Journal: Journal of the American College of Cardiology (2003)
How Squirrels Become Eunuchs.
Authors: Wm. P. Spratling
Journal: JAMA (1898)

Craig Colony, Sonyea, N. Y., Feb. 22, 1898. <h3>To the Editor:</h3> —Relative to the discussion now going on in theJournalon the above subject, let me say that many years ago it was my pleasure to spend several weeks each fall for five successive years in squirrel-hunting in the eastern section of middle Alabama. My daily tramps in the sport were made with an elderly companion, a man of 60 years, who all his life had been an ardent lover of the sport, and who loved nothing better than the daily rambles through the great forests where the tallest trees grew and where gray and red squirrels (the latter also known as the fox squirrel) abounded. One day I shot a young male and on picking him up was surprised to find the entire scrotal sac missing, with evidence of a recent injury to the parts. I called my
Have Byrne &amp; Hilbert answered Hardin's challenge?
Authors: Adam Pautz
Journal: Behavioral and Brain Sciences (2003)

Abstract I argue that Byrne &amp; Hilbert (B&amp;H) have not answered Hardin's objection to physicalism about color concerning the unitary-binary structure of the colors for two reasons. First, their account of unitary-binary structure seems unsatisfactory. Second, pace B&amp;H, there are no physicalistically acceptable candidates to be the hue-magnitudes. I conclude with a question about the justification of physicalism about color.
Complementary Therapies in Medicine—The Journal for All Health Care Professionals
Authors: Denise D. McKee
Journal: JAMA (1994)

Now in its second year of publication,<i>Complementary Therapies in Medicine</i>states its aims and scope as "primarily for those whose background is in traditional health care practices and who are seeking objective and critical guidance and information about complementary therapies." Its unique feature, among holistic and alternative medicine journals, is that it provides a forum for the traditional allopath to explore and discuss issues in complementary medicine previously considered alternative or "fringe." The term complementary medicine was first introduced in the medical literature in the<i>Lancet</i>in 1985.<sup>1</sup> A credit to the journal is the international representation on its advisory board. The editorial board is described as "the ablest talents of both conventional and complementary medicine available in the United Kingdom," although qualifications and degrees are not listed for either board. Manuscripts are peer reviewed and may not be submitted simultaneously to other English-language journals. All are subject
Airborne Transmission of Chickenpox in a Hospital
Authors: Jeanne M. Leclair, John A. Zaia, Myron J. Levin, Richard G. Congdon, Donald A. Goldmann
Journal: New England Journal of Medicine (1980)

The occurrence of chickenpox in pediatric hospitals disrupts routine care of immunologically normal patients and is potentially life-threatening to immunosuppressed patients.1 , 2 Guidelines for prevention of nosocomial chickenpox that are published by the Center for Disease Control recommend that patients with chickenpox be placed in isolation rooms and that personnel entering the room wear gown, gloves, and mask.3 These recommendations are based on observations suggesting that chickenpox is transmitted via the air.4 5 6 7 8 9 However, airborne spread has never been unequivocally demonstrated, and the reports of varicella spread by this route have not adequately excluded alternative modes of transmission.4 5 6 7 8 9 Moreover, the low secondary . . .
Circadian Variation in Defibrillation Energy Requirements
Authors: Ferdinand J. Venditti, Roy M. John, Michael Hull, Geoffrey H. Tofler, David M. Shahian, David T. Martin
Journal: Circulation (1996)

Reports have demonstrated a circadian variation in the incidence of acute myocardial infarction, ventricular arrhythmias, and sudden cardiac death. We tested the hypothesis that a similar circadian variation exists for defibrillation energy requirements in humans.We reviewed the time of defibrillation threshold (DFT) measurements in 134 patients with implantable cardioverter-defibrillators (ICDs) who underwent 345 DFT measurements. The DFT was determined in 130 patients at implantation, in 121 at a 2 months, and in 94 at 6 months. All patients had nonthoracotomy systems. The morning DFT (8 AM to 12 noon) was 15.1 +/- 1.2 J compared with 13.1 +/- 0.9 J in the midafternoon (12 noon to 4 PM) and 13.0 +/- 0.7 J in the late afternoon (4 to 8 PM), P < .02. In a separate group of 930 patients implanted with an ICD system with date and time stamps for each therapy, we reviewed 1238 episodes of ventricular tachyarrhythmias treated with shock therapy. To corroborate the hypothesis that energy requirements for arrhythmia termination vary during the course of the day, we plotted the failed first shock frequency for all episodes per hour. There was a significant peak in failed first shocks in the morning compared with other time intervals (P = .02).There is a morning peak in DFT and a corresponding morning peak in failed first shock frequency. This morning peak resembles the peaks seen in other cardiac events, specifically sudden cardiac death. These findings have important implications for appropriate ICD function, particularly in patients with marginal DFTs.
Prostaglandin F2α receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-β
Authors: Toru Oga, Toshiyuki Matsuoka, Chengcan Yao, Kimiko Nonomura, Shiho Kitaoka, Daiji Sakata, Yoshihiro Kita, Kiminobu Tanizawa, Yoshio Taguchi, Kazuo Chin, Michiaki Mishima, Takao Shimizu, Shuh Narumiya
Journal: Nature Medicine (2009)
Health Care Crisis From a Trauma Center Perspective
Authors: Edward E. Cornwell
Journal: JAMA (1996)

In the summer of 1995, the chief administrative officer of the County of Los Angeles proposed closure of Los Angeles County+University of Southern California (LAC + USC) Medical Center, the nation's biggest and busiest hospital, in order to address a budgetary shortfall of $655 million in the Los Angeles County Health Department. The magnitude of the fiscal crisis facing the Los Angeles County public health system is perhaps best demonstrated by the fact that the County Board of Supervisors gave serious consideration to the proposal, despite widespread predictions that such a move would trigger collapse of the nation's second-largest public health system.<sup>1</sup>(The Los Angeles County emergency agency has predicted a "dominolike" effect of closure of LAC + USC, where other hospitals' emergency departments would be overwhelmed by the numbers and complexities of patients for whom care would be unreimbursed.) Considering that the hospital (1) is the country's largest teaching hospital,