tbuckley/cabot-search huggingface dataset:
The Hematology Journal
Authors: R. G. Lerner
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hospital deaths are on decline, but change is slow, says new report
Authors: A. Cole
Journal: BMJ (2012)

The number of people dying at home rose in the past five years, while hospital deaths declined, show the latest figures on care at the end of life in England.

The latest report from the NHS’s National End of Life Care Intelligence Network, which pulls together a range of studies and surveys, shows that the proportion of deaths that occurred at home rose from 18.3% in 2004 to 20.8% in 2010. Meanwhile hospital deaths fell from 58.3% in 2005 to 53.3% in 2010.

This reverses a long term trend. In 1900 more than four in five people died at home. …
Manufacturers Develop Better Skin Protection Products
Authors: L. B. Crossette
Journal: JNCI Journal of the National Cancer Institute (1991)

Manufacturers Develop Better Skin Protection Products Get access Linda Baute Crossette Linda Baute Crossette Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 11, 5 June 1991, Page 753, https://doi.org/10.1093/jnci/83.11.753-a Published: 05 June 1991
Prevention of measles: vaccine efficacy and potential effectiveness of a vaccination programme on entry to school.
Authors: V Fernandes, O N Gill
Journal: BMJ (1985)

Etude a propos d'une epidemie de rougeole dans une ecole primaire. Revue des antecedents de tous les enfants. Confirmation de la valeur du programme de vaccination systematique lors de l'entree a l'ecole. La plus grande partie de la morbidite serieuse par rougeole serait evitee si les enfants susceptibles, facilement identifiables le plus souvent, etaient vaccines correctement lors de l'entree a l'ecole
Footprints of the EADV: a meeting report from the 17th Congress of the European Academy of Dermatology and Venereology
Authors: A.B. Alexandroff, R. Burd
Journal: British Journal of Dermatology (2009)

Journal Article Footprints of the EADV: a meeting report from the 17th Congress of the European Academy of Dermatology and Venereology Get access A.B. Alexandroff, A.B. Alexandroff Department of Dermatology, Leicester Royal Infirmary, Leicester LE1 5WW, U.K. Correspondence: A.B. Alexandroff. E‐mail: anton.alexandroff@gmail.com Search for other works by this author on: Oxford Academic Google Scholar R. Burd R. Burd Department of Dermatology, Leicester Royal Infirmary, Leicester LE1 5WW, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 160, Issue 5, 1 May 2009, Pages 938–945, https://doi.org/10.1111/j.1365-2133.2009.09107.x Published: 01 May 2009
Analysis of serial measurements in medical research.
Authors: S Senn
Journal: BMJ (1990)

stung region.In the case of stone fish poisoning, however, it is best that the concentrated necrotising venom is allowed to diffuse freely away from the region.Deaths due to the svstemic effects of the venom are extremely rare, with onlv a couple recorded in published work.Infection often occurs with this type of injury.It should be remembered that marine bacteria comprise a wide range of organisms, and many are resistant to common antibiotics and also may require saline media for culture.It follows that debridement should be assisted by washing the wound well with fresh or preferably sterile water.The drug of first choice is trimethoprim-sulpha- methazole.Tetanus prophvlaxis should also receive attention.
John Thomas Kennedy
Authors: Thomas M Paterson
Journal: BMJ (2004)

Former general practitioner Stoke-on-Trent (b County Tipperary, Ireland, 1915; q Dublin 1946), died from cardiovascular disease on 27 January 2004.​2004.




Figure 1




John moved to north Staffordshire in the 1950s, entering general practice in Stoke-on-Trent, where he continued as a family doctor until his retirement. He came from a farming family and had a great love and knowledge of the countryside. He was a keen golfer and his name figures in Trentham Golf Club's book of outstanding achievements as the oldest member to win a medal (at the age of 86). His wife, Renee, predeceased him.
Neuroscientist/Psychiatrist Takes Helm at Flagship Primate Research Center
Authors: Andrew A. Skolnick
Journal: JAMA (1994)

AFTER a 16-year tour of duty, Frederick A. King, PhD, an outspoken defender of animal research, retired September 1 as director of Yerkes Regional Primate Research Center of Emory University, Atlanta, Ga. His replacement, Thomas R. Insel, MD, a psychiatrist-turned-neuroscientist, is the first physician to head what is widely regarded as the flagship of the seven primate research centers funded by the National Institutes of Health (NIH). With its large colonies of 10 monkey species, gibbons (the lesser ape), and all four species of great apes, the Yerkes center is a major site for basic research into cardiovascular disease, congenital vision defects, AIDS and other infectious diseases, Parkinson's disease, drug addiction, fertility control, and many other areas of biomedicine as well as studies in social behavior and conservation (see following article). King, who led the Yerkes center during its period of maximum growth and maximum opposition from the animal rights
Tacrine and lecithin in Alzheimer's disease
Authors: J R Murray, C B Blakemore
Journal: BMJ (1990)

SIR,-As two general practitioners in Bradford who are actively concerned in providing maternity care we would like to comment on the paper by Dr F C Bryce and colleagues on general practitioner obstetrics in Bradford.'We have worked in Bradford in different practices for two years and one year respectively.We both have experience of schemes of community antenatal care in Hackney and Tower Hamlets that are looselv based on the Sighthill model.2We are convinced that such schemes succeed because of cooperation between hospital and community staff, which results from the development and implementation of agreed protocols for maternity care.In contrast we found that the lack of any such protocols in Bradford and the poor communication among colleagues created a sense of isolation among general practitioner obstetricians.We were first aware of the paper by Dr Brvce and colleagues in September 1989, when an earlier draft was circulated to local general practitioners.There was no general practitioner or midwife participation in the preparation of the paper.Its tone was felt by many general practitioners to be admonitory and divisive.Trhere was an immediate response bv general practitioners in Bradford, manv of whom wrote letters to the local medical committee, which prepared a paper in response.No further communication occurred until the obstetricians' paper, slightly modified, appeared in the BM7, almost six months after we had first seen it.As far as we are aware no account had been taken of the large response from general practitioners that it had generated.The thrust of our response to the original paper was that the key to better maternity care in Bradford is good communication and cooperation among all those concerned: consumers, midwives, general practitioners, and consultants.We regret the style of the paper and would question its scientific validity in view of the small numbers studied.Nevertheless, we welcome the opening up of the debate and hope that it may be possible to move the discussion out of the hospital and into the community.Specifically, we propose that consul- tants should come into the community clinics on a regular basis.This would lead to improved communication.Consultants would share their expertise and provide continuing clinical advice and education.Midwives and general practitioners would benefit from the support provided by such contact, and, above all, the women of Bradford would benefit from expert, well planned, locally based maternity care.
Cardiac Pacing: A Concise Guide to Clinical Practice
Authors: Robert J. Henning
Journal: JAMA (1980)

Throughout the world 400,000 people have had electrical pacemaker systems implanted, including more than 150,000 people in the United States. Each year 60,000 pacemakers from approximately 20 major manufacturers of pulse generators are implanted in the United States alone. Basic information concerning electrical pacing systems is therefore important to all physicians who treat cardiac patients. In<i>Cardiac Pacing</i>cardiologist Philip Varriale and thoracic surgeon Emil Naclerio, in conjunction with other experts in the technology and practice of cardiac pacing, discuss the electrophysiological concepts of cardiac pacing, the role of pacing in the management of patients with heart block and cardiac arrhythmias, the components of implantable pacing systems, and the techniques of surveillance important for pacemaker longevity. The 329-page text is divided into 23 chapters. Cardiac conduction anatomy, conduction abnormalities, including bifascicular and trifascicular block and sick sinus syndrome, and indications for permanent cardiac pacing are briefly reviewed. Chapters on the
Preventing Health Care–Associated Harm in Children
Authors: Kathleen E. Walsh, David G. Bundy, Christopher P. Landrigan
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eroded and Pedunculated Buttock Nodule
Authors: Karen Itumeleng Mosojane, Lara Wine Lee, Carrie L. Kovarik
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Cumulative depletions of extracellular calcium in rabbit ventricular muscle monitored with calcium-selective microelectrodes.
Authors: D M Bers, K T MacLeod
Journal: Circulation Research (1986)

Transient changes of extracellular free calcium in rabbit ventricular muscle under nonsteady state conditions were measured with double-barreled calcium microelectrodes. Resumption of stimulation after a rest interval produces a cumulative decrease of extracellular free calcium often by more than 10% (with bulk extracellular free calcium = 0.2 mM). The extracellular free calcium returns to the bulk value as a new steady state is achieved. The changes of extracellular free calcium recorded presumably represent net calcium uptake and loss by cardiac muscle cells. These cumulative extracellular free calcium depletions are blocked by 0.5 mM cobalt and 1 microM nifedipine and are increased to 167 +/- 11% of control by the calcium agonist Bay k 8644 (1 microM) and to 620 +/- 150% of control by increasing stimulus frequency from 0.2-2 Hz. Caffeine (10 mM) inhibits the cumulative extracellular free calcium depletions, probably by rendering the sarcoplasmic reticulum unable to accumulate calcium. It is proposed that the extracellular free calcium depletions recorded represent, in large part, calcium which has entered the cells and has been taken up by the sarcoplasmic reticulum (which had become depleted of calcium during the rest interval). Nifedipine and cobalt inhibit these cumulative depletions presumably by preventing the calcium entry which could subsequently be accumulated by the sarcoplasmic reticulum. The net cellular calcium uptake produced by such a post-rest stimulation protocol can also be inhibited by 1-3 microM acetylstrophanthidin and reduction of extracellular sodium to 70 mM. Acetylstrophanthidin and low extracellular sodium would be expected to shift the sodium-calcium exchange in favor of increased calcium uptake, which may, in turn, prevent the loss of sarcoplasmic reticulum calcium during the rest interval. This would limit the amount of calcium which the sarcoplasmic reticulum could take up with subsequent activation. In contrast to the results with caffeine, ryanodine (1 microM) increases the magnitude and rate of calcium uptake after a rest interval, indicative of a fundamental difference in the actions of caffeine and ryanodine. When stimulation is stopped in the presence of ryanodine, extracellular free calcium increases much faster than in control. This suggests that ryanodine may enhance calcium uptake by the sarcoplasmic reticulum during repetitive stimulation and may enhance calcium efflux from the sarcoplasmic reticulum during quiescence. These experiments provide insight into transsarcolemmal calcium movements and certain aspects of cellular calcium regulation.
Cardiovascular Effects of Mechanical Ventilation and Positive End-Expiratory Pressure
Authors: Shari L. Farrell
Journal: JAMA (1985)

<h3>To the Editor.—</h3> There is one comment we would like to make on Dr Luce's<sup>1</sup>discussion of cardiovascular effects of mechanical ventilation (MV) and positive end-expiratory pressure (PEEP). He says that "right ventricular after-load may be appreciably elevated in patients with ARDS [adult respiratory distress syndrome] receiving MV and high levels of PEEP." While this statement may be true, it suggests that the use of PEEP in ARDS may raise right ventricular afterload to a higher level than the primary disease. This is not always true. In ARDS, lung volumes fall, and with the fall in lung volume, right ventricular afterload rises. Using PEEP in a patient with ARDS and low lung volumes may actually decrease vascular resistance and lower right ventricular afterload. Overdistention of the lung to higher than normal lung volumes may raise pulmonary vascular resistance. The effect of PEEP on pulmonary vascular resistance is, in part,
Standardisation of outcome measures (z scores)
Authors: P. Sedgwick
Journal: BMJ (2012)

Researchers investigated the effects of weekly vitamin D supplements on the mortality, morbidity, and growth of low birthweight term infants up to 6 months of age in India. A randomised placebo controlled trial was used. In total, 2079 low birthweight infants born at term (>37 weeks’ gestation) were randomised to intervention or control. Intervention consisted of weekly vitamin D supplements for six months at a dose of one recommended nutrient intake per day (35 μg/week) dissolved in a small amount of expressed breast milk (or other milk for non-breastfed infants).1

Primary outcomes were admission to hospital or death during the first six months of life. Secondary outcomes included weight, length, mid-upper arm circumference, and head circumference at six months. Each anthropometric measure was transformed to z scores for age and sex using World Health Organization growth reference charts. The researchers reported that a weekly dose of vitamin D in young …
Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis
Authors: Bryna S. Man Chow, Martina Kocan, Sanja Bosnyak, Mohsin Sarwar, Belinda Wigg, Emma S. Jones, Robert E. Widdop, Roger J. Summers, Ross A.D. Bathgate, Tim D. Hewitson, Chrishan S. Samuel
Journal: Kidney International (2014)
THE LATENT MASTOID AS A CAUSE OF CHRONIC AURAL SEPSIS
Authors: G. Chubb
Journal: BMJ (1933)

OURNALwe found a leaking aneurysm of the left side of the circle of NVillis, which had burst.In another case in my department, under Mr. Angell James, mastoiditis was simulated and an operation per- formed; the lesion was an aneurysm of the basilar artery.O6phoritis appears occasionally to produce earache.Sometimes we are compelled to regard the earache as functional in origin, as in the case described below.CASE IX.-Neurotic " Earache " R. N., a female aged 24, was admitted as a case of mastoiditis, with severe left earache, intense tenderness to lightest touch on mastoid and behind, giddiness, and falling.No nystagmus or nausea.Temperature 98.60 F., pulse 76; hearing normal, tympanic membrane normal.She seemed quite quiet and intelligent, and anxious to have an operation " anything to get rid of the pain."Careful examination revealed no physical signs.I made the diagnosis of quasi- hysterical neurosis, which rather startled her own doctor.When told that no operation was necessary she lost all pain.Later I found out that she had just lost her job.Three years before she had suffered from hysteria, her betrothed having married her best friend just before the date fixed for her own wedding.
Selective NOS Inhibition Restores Myocardial Contractility in Endotoxemic Rats; However, Myocardial NO Content Does Not Correlate with Myocardial Dysfunction
Authors: IFEDIORA F. AFULUKWE, RUBIN I. COHEN, GUILLERMO A. ZEBALLOS, MOBEEN IQBAL, STEVEN M. SCHARF
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

The role of nitric oxide (NO) in lipopolysaccharide (LPS)-induced myocardial dysfunction remains controversial as some investigators concluded that inhibition of NO synthesis improves left ventricular (LV) contractility, whereas others did not. We investigated the relationship between LPS-induced LV dysfunction and LV NO production. We postulated that high myocardial NO concentrations would correspond to decreased contractility and low NO concentrations would correspond to recovery. In a rat model of endotoxemia, we used the isolated papillary preparation to assess inotropic dysfunction. We measured LV NO content and hemodynamics at baseline, 4, 16, and 48 h after LPS administration. LPS caused a decrease in LV contractility at 16 h with recovery at 48 h. Myocardial NO levels were elevated at all time periods. However, at 48 h in spite of normalization of LV contractility, myocardial NO content remained elevated. Pretreatment of LPS animals with the nonselective nitric oxide synthase (NOS) inhibitor N G-nitro-l-arginine methyl ester (l-NAME) worsened LV contractility, decreased LV NO content, and increased mortality. However, pretreatment with the relatively selective inducible NOS (iNOS) inhibitor S-methylisothiourea sulfate (SMT) restored LV contractility. Myocardial NO content in the SMT was lower than that of the LPS only group, but higher than the l-NAME group. We conclude that SMT is beneficial to myocardial contractility in this model of endotoxemia, whereas pretreatment with l-NAME is associated with further deterioration of contractility and increased mortality. Moreover, our data indicate that high myocardial NO concentrations do not necessarily correlate with decreased contractility.
Points: Asbestos and burgundy
Authors: G. Flavell
Journal: BMJ (1980)

Social class and private referrals Patients opting Total referred for private Social class population referral 1 5 % 9% 2 22-9% 40°% 3 56-6% 440°o 4 12-1% 6°,' 5 3-2°1% N= 694(100%) N= 139(100°o)health insurance schemes.Of 43 domiciliary visits by specialists, 10 (23 %) were carried out in private consultations although only six (14%) patients belonged to a private health insurance scheme.I agree that much more information is required about private practice in this country but I submit that the statistics presented here are rather more "central" than "peripheral."
Doxorubicin-loaded NaYF4:Yb/Tm–TiO2 inorganic photosensitizers for NIR-triggered photodynamic therapy and enhanced chemotherapy in drug-resistant breast cancers
Authors: Leyong Zeng, Yuanwei Pan, Ying Tian, Xin Wang, Wenzhi Ren, Shouju Wang, Guangming Lu, Aiguo Wu
Journal: Biomaterials (2015)
Cholesterol Screening: Hits and Misses
Authors: Burgess Record
Journal: JAMA (1991)

<h3>To the Editor.</h3> —Congratulations to Havas et al<sup>1</sup>for having valued the forest despite the imperfection of a few of its trees. Granted the inevitable minor (3.6%) misclassifications that have bothered Havas et al in past public presentations, results of the Massachusetts Model Systems for Blood Cholesterol Screening Project do confirm the utility of cholesterol screening and counseling in community settings. In screening situations, perhaps the message ("know your numbers... modify your diet and other behaviors... repeat your cholesterol measurement and follow-up with your physician") is more important than the precise number. People in general and physicians in particular should realize that individuals' cholesterol levels often vary widely from day to day. Any single cholesterol determination, whether by finger-stick screening or as part of a fasting lipid profile, is but one point within the person's usual cholesterol range, which may well overlap the boundaries of any finite classification system. The