Cisplatin and Hyponatremia
Authors: XAVIER MARIETTE
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 May 1988Cisplatin and HyponatremiaXAVIER MARIETTE, M.D., BERNARD PAULE, M.D., PASCAL BENNET, M.D., DIDIER CLERC, M.D., MICHEL BISSON, M.D., PIERRE MASSIAS, M.D.XAVIER MARIETTE, M.D.Search for more papers by this author, BERNARD PAULE, M.D.Search for more papers by this author, PASCAL BENNET, M.D.Search for more papers by this author, DIDIER CLERC, M.D.Search for more papers by this author, MICHEL BISSON, M.D.Search for more papers by this author, PIERRE MASSIAS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-5-770_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Hutchinson and associates (1) reported renal salt wasting in 7 of 70 patients treated with cisplatin. These patients had severe persistent orthostatic hypotension requiring prolonged treatment with fludrocortisone and sodium chloride supplements. Six of these patients had hyponatremia (116 to 132 mmol/L). Plasma renin activity and aldosterone concentration were low. The stimulation of vasopressin activity by the resultant hypovolemia might account for the hyponatremia.Of 20 patients treated with cisplatin during the last 2 years for skeletal metastases, we observed six episodes of transient hyponatremia (less than 130 mmol/L) without symptomatic orthostatic hypotension in 3...References1. HUTCHINSONPEREZGANDARALAWRENCEKAYSEN FEDHG. Renal salt wasting in patients treated with cisplatin. Ann Intern Med. 1988;108:21-5. LinkGoogle Scholar2. BLACHLEYHILL JJ. Renal and electrolyte disturbances associated with cisplatin. Ann Intern Med. 1981;95:628-32. LinkGoogle Scholar3. LAMMERSWHITEETTINGER PLL. Cis-platinum-induced renal sodium wasting. Med Pediatr Oncol 1984;12:343-6. CrossrefMedlineGoogle Scholar4. KURTZBERGDENNISKINNEY JVT. Cis-platinum-induced renal salt wasting. Med Pediatr Oncol. 1984;12:150-4. CrossrefMedlineGoogle Scholar5. GIACCONEDONADIOFERRATI GMP. Disorders of serum electrolytes and renal function in patients treated with cis-platinum on an outpatient basis. Eur J Cancer Clin Oncol. 1985;21:433-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hôpital de Bicêtre 94275 Le Kremlin Bicêtre France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHiponatremia luego de uso de cisplatino: a propósito de un casoPlatinum-containing cytostatic drugsDRUGS USED IN CANCER CHEMOTHERAPYCisplatin OverdosePlatinum-containing cytostatic drugsSodium-Wasting Nephropathy Caused by Cisplatin in a Patient with Small-Cell Lung CancerToxicity of platinum compoundsCytostatic drugsCisplatin and acute tubular necrosisHyponatremia related to medical anticancer treatmentCytostatics and immunosuppressive drugsHyponatraemia Following Cisplatin Chemotherapy 1 May 1988Volume 108, Issue 5Page: 770-771KeywordsAldosteroneAttentionFludrocortisoneHyponatremiaHypotensionPlasma renin activitySaltsSodium chlorideVasopressin Issue Published: 1 May 1988 PDF DownloadLoading ...