tbuckley/cabot-search huggingface dataset:
Evaluation of a 1-h exposure time to mechlorethamine in patients undergoing topical treatment
Authors: P. Foulc, V. Evrard, S. Dalac, B. Guillot, M. Delaunay, J-L. Verret, B. Dreno
Journal: British Journal of Dermatology (2002)

Journal Article Evaluation of a 1‐h exposure time to mechlorethamine in patients undergoing topical treatment Get access P. Foulc, P. Foulc Department of Dermatology, CHU Nantes, 1 place Alexis Ricordeau, 44035 Nantes cedex 1, France Search for other works by this author on: Oxford Academic Google Scholar V. Evrard, V. Evrard Department of Dermatology, CHU Nantes, 1 place Alexis Ricordeau, 44035 Nantes cedex 1, France Search for other works by this author on: Oxford Academic Google Scholar S. Dalac, S. Dalac Department of Dermatology, CHU Dijon, Dijon, France Search for other works by this author on: Oxford Academic Google Scholar B. Guillot, B. Guillot Department of Dermatology, CHU Nîmes, Nîmes, France Search for other works by this author on: Oxford Academic Google Scholar M. Delaunay, M. Delaunay Department of Dermatology, CHU Bordeaux, Bordeaux, France Search for other works by this author on: Oxford Academic Google Scholar J‐L. Verret, J‐L. Verret Department of Dermatology, CHU Angers, Angers, France Search for other works by this author on: Oxford Academic Google Scholar B. Dréno B. Dréno Department of Dermatology, CHU Nantes, 1 place Alexis Ricordeau, 44035 Nantes cedex 1, France Brigitte Dréno. E‐mail: bdreno@wanadoo.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 147, Issue 5, 1 November 2002, Pages 926–930, https://doi.org/10.1046/j.1365-2133.2002.04802.x Published: 01 November 2002 Article history Accepted: 17 January 2002 Published: 01 November 2002
GPIHBP1 Is Responsible for the Entry of Lipoprotein Lipase into Capillaries
Authors: Brandon S.J. Davies, Anne P. Beigneux, Richard H. Barnes, Yiping Tu, Peter Gin, Michael M. Weinstein, Chika Nobumori, Rakel Nyrén, Ira Goldberg, Gunilla Olivecrona, André Bensadoun, Stephen G. Young, Loren G. Fong
Journal: Cell Metabolism (2010)
THE TREATMENT OF HEMOPTYSIS IN PULMONARY TUBERCULOSIS
Authors: NEWELL BLY BURNS
Journal: JAMA (1913)

Hemoptysis of known pulmonary origin in tuberculosis is now treated at North Reading in a rather original manner. The plan in use was selected for its superiority after three years of gradual elimination of various forms of treatment.  Many methods commonly employed to cope with pulmonary hemorrhage were discarded after a fair trial on account of inefficiency and harmful sequelae. For instance, morphin, generally advocated and no doubt extensively used in the treatment of this complication, has fallen decidedly out of favor with us. The text-books offer it for use by reason of the indication for the depression of respiratory activity, the allaying of excitement, and the suppression of cough. The idea is that all efforts should cooperate toward quieting the patient, but this seems to be without due regard for the alleviation of the trouble which causes the disturbance. Let one who prescribes morphin in such instances remain at the patient's bedside to observe the
Safety of Hydrolysates in Parenteral Nutrition
Authors: L. J. Filer, Lewis D. Stegink
Journal: New England Journal of Medicine (1973)

Elsewhere in this issue of the Journal, an article by Olney, Ho and Rhee questions the safety of protein hydrolysates for use as the nitrogen source in total parenteral nutrition of the human infant. This study reports the production of a Central-nervous-system lesion in the infant mouse after subcutaneous injection of protein hydrolysate solutions containing glutamate, aspartate and cysteic acid. That these "acidic" amino acids alone or in combination produce Central-nervous-system lesions in the suckling mouse is a matter of record.The neurotoxic effects of these amino acids in species other than the mouse are debatable. Descriptions of glutamate-induced . . .
Recombinant Bet v 1, the major birch pollen allergen, induces hypersensitivity reactions equal to those induced by natural Bet v 1 in the airways of patients allergic to tree pollen☆, ☆☆, ★, ★★
Authors: J GODNICCVAR, M SUSANI, H BREITENEDER, A BERGER, L HAVELEC, T WALDHOR, R HIRSCHWEHR, R VALENTA, O SCHEINER, H RUDIGER
Journal: Journal of Allergy and Clinical Immunology (1997)
Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells.
Authors: S Kagami, W A Border, D E Miller, N A Noble
Journal: Journal of Clinical Investigation (1994)

Angiotensin II (Ang II) has been implicated in the development of progressive glomerulosclerosis, but the precise mechanism of this effect remains unclear. In an experimental model, we have shown previously that TGF-beta plays a key role in glomerulosclerosis by stimulating extracellular matrix protein synthesis, increasing matrix protein receptors, and altering protease/protease-inhibitor balance, thereby inhibiting matrix degradation. We hypothesized that Ang II contributes to glomerulosclerosis through induction of TGF-beta. Ang II treatment of rat mesangial cells in culture increased TGF-beta and matrix components biglycan, fibronectin, and collagen type I at both the mRNA and protein levels in a time- and dose-dependent manner. Saralasin, a competitive inhibitor of Ang II, prevented the stimulation. Ang II also promoted conversion of latent TGF-beta to the biologically active form. Coincubation of mesangial cells with Ang II and neutralizing antibody to TGF-beta blocked the Ang II-induced increases in matrix protein expression. Continuous in vivo administration of Ang II to normal rats for 7 d resulted in 70% increases in glomerular mRNA for both TGF-beta and collagen type I. These results indicate that Ang II induces mesangial cell synthesis of matrix proteins and show that these effects are mediated by Ang II induction of TGF-beta expression. This mechanism may well contribute to glomerulosclerosis in vivo.
Cardiovascular Hemodynamic Functions in Complete Heart Block and the Effect of Isopropylnorepinephrine
Authors: MARIA F. STACK, BERTHA RADER, BRUCE J. SOBOL, SAUL J. FARBER, LUDWIG W. EICHNA
Journal: Circulation (1958)

In 8 patients with complete heart block, cardiac and hemodynamic functions were determined by methods based on cardiac catheterization. The data characterize the impairment in these functions in asymptomatic subjects and indicate, in addition, the further changes over the course of several years in the same subject, the deleterious effects associated with congestive heart failure, and the changes toward normal induced by isopropylnorepinephrine, a sympathomimetic amine known to stimulate the heart and increase ventricular rate in heart block.
Drug smoking, Pneumocystis carinii pneumonia, and immunosuppression increase risk of bacterial pneumonia in human immunodeficiency virus-seropositive injection drug users.
Authors: W T Caiaffa, D Vlahov, N M Graham, J Astemborski, L Solomon, K E Nelson, A Muñoz
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

To examine the risk factors for the first episode of bacterial pneumonia among human immunodeficiency virus (HIV)-seropositive injection drug users (IDUs), medical record review was performed on IDUs participating in a cohort study from January 1988 to June 30, 1992. HIV-seropositive IDUs with a first episode of bacterial pneumonia (n = 40) were matched with up to five HIV-seropositive control subjects without bacterial pneumonia (n = 197) by date of entry (+/- 3 mo) and length of follow-up. Odds ratios (OR) were estimated using conditional logistic regression. The incidence of bacterial pneumonia was 1.93 in 100 person-years in HIV seropositive and 0.45 in 100 person-years in HIV seronegative subjects (relative incidence = 4.3; 95% CI 2.4 to 7.5). In univariate analyses, CD4 lymphocyte count < 200 cells/microliters previous episode of Pneumocystis carinii pneumonia (PCP), age between 30 and 40 yr and smoking illicit drugs (marijuana, cocaine, or crack) were associated with bacterial pneumonia. Cigarette smoking was associated with an increased odds of bacterial pneumonia (OR = 2.0), but this was not statistically significant because it was nearly universal in this cohort. In multivariate analysis, CD4 < 200 cells/microliters (OR = 6.75, 95% CI 2.13 to 21.42) and smoking illicit drugs (OR = 2.24, 95% CI 1.03 to 4.89) remained significantly associated with bacterial pneumonia. The odds ratio for cigarette smoking in the final model remained at 2.08 but was still not significant (95% CI 0.49 to 8.70). Smoking illicit drugs had the strongest effect on risk of bacterial pneumonia among HIV-seropositive IDUs with a previous history of PCP (OR = 22.94; 95% CI 2.18 to 241.10).
A CASE ILLUSTRATING ARTIFICIAL PNEUMOTHORAX, ADHESION CUTTING, AND OLEOTHORAX
Authors: F. G. Chandler
Journal: BMJ (1932)

PNEUMOTHORAX: ADHESION CUTFITING: OLEOTHORAX TMEBIATIASL foot.The result of cord syrmpatliectomy was poor.The right lower extremity shows some improvement, but the left was amputated two months afterwards for gangrene.Male, aged 45 years.Rise of temperature under spinal anaesthesia 30 C. in the right foot and 1.60 C. in the left foot.The result of cord sympathectomy is fairly satisfactory, and a gangrenous ulcer on the inner side of the left ankle healed rapidly.Male, aged 41 years.Rise of temperature under spinal anaesthesia 6.40 C. in the right foot and 5.8°C. in the left fcot.The result of cord sympathectomy is entirely satis- factory, and the patient is in active work.
Characteristics of 98 Children and Adolescents Diagnosed With Type 2 Diabetes by Their Health Care Provider at Initial Presentation
Authors: Sandra L. Upchurch, Christine A. Brosnan, Janet C. Meininger, Doris E. Wright, Jill A. Campbell, Siripoom V. McKay, Barbara Schreiner
Journal: Diabetes Care (2003)

Although the number of children and youth with type 2 diabetes is increasing, a clear case definition that describes children with type 2 diabetes at presentation remains elusive. Most initial diagnoses are decided on the clinical picture at presentation (1). Characteristics and risk factors have been outlined in several review and clinical articles (2–4). The purpose of this study was to describe the characteristics of youth presenting for an initial visit to the outpatient clinic of a large tertiary children’s care center and diagnosed with type 2 diabetes.

For this retrospective study, data were abstracted from a consecutive …
Outcomes of screening to prevent cancer: Think of screening as insurance
Authors: P. D Sasieni
Journal: BMJ (2003)

EDITOR—Raffle et al provide interesting new data on the outcome of cervical screening.1 It is particularly useful to be able to tell women that over 20 years of five yearly screening, around 16% will have an abnormal smear test result, 8% will have a biopsy, and 4% will be treated for high grade disease.

The authors also estimate the number of cancers and deaths that might be prevented over 30 years in such a cohort. How they …
Trusts have used part of 700m winter pressures fund to pay off debts, doctors claim
Authors: G. Iacobucci
Journal: BMJ (2015)

Only a fraction of the £700m allocated by the government to help ease pressures in emergency departments in England this winter has been spent on frontline emergency department services, say senior clinicians.

A College of Emergency Medicine survey of senior consultants working in emergency departments found that only 1% (£6 685 000) of the money allocated by the government for 2014-15 was spent directly on emergency department services.1 The college said that the “derisory” allocation was a result of hospital trusts using additional funds to pay off debts and diverting funds to schemes that had failed to reduce attendances or admissions.

The survey of senior emergency department consultants across the United Kingdom found slow progress …
Central retinal vein occlusion and scleroderma: implications for sclerodermatous vascular disease.
Authors: G O Littlejohn, M B Urowitz, C J Pavlin
Journal: Annals of the Rheumatic Diseases (1981)

A patient with scleroderma (progressive systemic sclerosis) who developed central retinal vein occlusion is described. The aetiology of this condition is discussed and the role of possible sclerodermatous vascular disease is highlighted. It is suggested that studies of fundal vasculature could be useful in the clinical assessment of sclerodermatous vascular disease.
Faecal pH and colon cancer.
Authors: S L Malhotra
Journal: Gut (1992)

<h3>Abstract</h3> Exposure to damaging levels of noise is the most common cause of hearing loss and impairs high frequency hearing in more than 15 % of adult Americans. Using mice exposed to increasing levels of noise in combination with quantitative proteomics, we tested how noise insults remodel the cochlear proteome both acutely and after a two-week recovery period. We used ABR &amp; DPOAE recordings to define the intensity of noise exposure necessary to produce temporary or permanent threshold shifts (TTS, PTS) in young adult mice and found noise at 94 and 105 dB SPL levels for 30 minutes elicits TTS and PTS, respectively. We quantified thousands of proteins and found that noise insults cause a rapid increase rather than a decrease in the levels of many proteins involved with protein homeostasis, myelin, cytoskeletal structures, and cell junctions such as the synapse. The vast majority of proteins with increased levels immediately after noise exposure showed normal levels after two weeks of recovery. However, several proteins involved in oxidative stress and neuroprotection had significantly increased levels only after the recovery period suggesting they play in important role in regeneration. Interestingly, a small panel of mitochondrial proteins were significantly altered only in PTS conditions suggesting potential discrete protein mechanisms. Our discovery-based proteomic analysis extends the recent description of noise-induced cochlear synaptopathy and shows that noise insults drive a robust proteostasis response. These data provide a new understanding of noise sensitive proteins and may inform the development of effective preventiative strategies or therapies for NIHL.
What doctors have in common with architects--part 2: The common good
Authors: D. Loxterkamp, B. Snider
Journal: BMJ (2015)

In the first part of a two part dialogue on medicine and architecture (doi:10.1136/bmj.h1810), <b>David Loxterkamp</b> and <b>Bruce Snider</b> reflected on the effects of technological change on each profession. In this second part they discuss the social obligations of each
Right Atrial Myxoma Complicated by a Thrombus
Authors: George R. Holswade
Journal: JAMA (1965)

THE COMBINATION of right atrial myxoma and thrombi is apparently rare. Heath and MacKinnon<sup>1</sup>reviewed the subject recently and described the excision of a right atrial myxoma in a patient with pulmonary hypertension. In the case reported here, thrombi were present in association with a right atrial myxoma, but recurrence followed their removal and produced a fatal postoperative complication. <h3>Report of a Case</h3> A 57-year-old Caucasian housewife was in good health until three years prior to admission, when abdominal discomfort, flatulence, and a bloated sensation began. Fatigue, a nonproductive cough, ascites, and a right pleural effusion grew progressively worse. The liver was enlarged and a biopsy at another hospital led to a diagnosis of cirrhosis. On admission, on May 31, 1964, she was chronically ill with mild respiratory distress. Body temperature was 97.2 F (36.2 C), pulse 78 beats per minute, respirations 18 per minute, and blood pressure 100/70
Comparative Life History Differences of Families of Schizophrenics, Delinquents, and "Normals"
Authors: JAMES R. STABENAU, WILLIAM POLLIN
Journal: American Journal of Psychiatry (1968)

In this series of families the development of severe psychopathology (schizophrenia or delinquency) in the index child appeared to be linked with intense periods of family crisis occurring early in the child's life. A more conflictual parent-child relationship seemed to develop for that child as compared with a control sibling of the same sex, and more of the negative repudiated features of the parents' personalities were projected on him. The type of psychopathology that developed in the index child is thought to be connected with the style in which family members relate to one another.
Transthoracic ventricular defibrillation in the 100 kg calf with unidirectional rectangular pulses.
Authors: J H Gold, J C Schuder, H Stoeckle, T A Granberg, S Z Hamdani, J M Rychlewski
Journal: Circulation (1977)

The effectiveness in reversing ventricular fibrillation of 30 seconds duration of unidirectional rectangular-wave shocks having pulse widths of 0.5 through 64 msec, pulse amplitudes of 35, 50, 70, 100, and 140 amp, and pulse energies of 109 through 1,660 J was studied in 3,303 transthoracic fibrillation-defibrillation episodes in 100 kg calves. A total of 38 animals were used in the study. Postdefibrillation electrocardiograms were recorded. Families of curves of percent successful defibrillation vs pulse duration, percent successful defibrillation vs pulse energy, duration of postdefibrillation complete block or standstill vs energy, and time required for a return to normal sinus rhythm vs energy were derived. The most effective waveform studied (70 amp--8 msec--862 J) yielded defibrillation on the initial attempt in 93% of 120 episodes. In general, the duration of complete block or standstill and the time required for a return to normal sinus rhythm increased with increasing pulse current and pulse energy.
The Increase of Apolipoprotein A-V During Postprandial Lipemia Parallels the Response of Triglyceride-Rich Lipoproteins in Type 2 Diabetes
Authors: Juhani Kahri, Jamila Fruchart-Najib, Niina Matikainen, Jean-Charles Fruchart, Juha Vakkilainen, Marja-Riitta Taskinen
Journal: Diabetes Care (2007)

Postprandial lipemia is a distinct feature of diabetic dyslipidemia and may partly explain the atherogeneity of the lipid profile in type 2 diabetes (1). Several genetic factors contribute to the elevation of triglyceride-rich lipoproteins (TRLs). The role of apolipoprotein (apo)C-III as a regulator of TRL metabolism is well documented (2). Recently, apoA-V has been identified as a novel regulator of triglyceride metabolism. When the human APOA5 gene was expressed in transgenic mice, plasma triglyceride concentration was decreased by 70%, whereas apoA 5 gene knockout mice had fourfold elevation of plasma triglyceride levels (3). Inherited apoA-V deficiency results in severe hypertriglyceridemia in humans (4). A mutation in the APOA5 gene causes hypertriglyceridemia due to decreased lipoprotein lipase (LPL) mass and activity (5). Thus, previous studies have proposed that apoA-V decreases triglycerides by stimulating lipolysis.

The present study focused on the response of apoA-V and apoC-III during postprandial lipemia and the associations between apoA-V and apoC-III and postheparin plasma LPL and hepatic lipase activities in type 2 diabetes.

The present study cohort was comprised of 39 men and 8 women with type 2 diabetes who were enrolled in the previously published nateglinide study with the same inclusion and exclusion criteria (6). A total of 17 patients were treated with diet alone, 20 with sulfonylurea, and 11 with metformin. The …
Nature Encyclopaedia of the Human Genome
Authors: S. Abbs
Journal: BMJ (2004)

Five volumes, 5000 pages, three million words, 15.2 kg, £675—if it's nothing else, the Nature Encyclopaedia of the Human Genome is a heavyweight publishing phenomenon. How is it possible to write a sensible review of an encyclopaedia? According to at least one dictionary definition an encyclopaedia “provides a general overview on a topic… a good place to start research.” To test the encyclopaedia against this definition the three of us each chose a single topic to look up in the encyclopaedia. Here is what we found. Nature Publishing Group, £675/$950 (prepublication price), pp 5000 ISBN 0 333 80386 8http://www.ehgonline.net/ Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> Steve Abbs, a clinical molecular geneticist, chose “DNA mutation nomenclature,” a subject that is dear to his heart Clinical molecular geneticists spend their working lives finding, naming, and investigating genetic mutations. When I looked up “mutation” in the contents I was reassured to discover that most of the topics I was interested in (and more) were covered by individual chapters, all written by international experts in their field. I looked in detail at the article “Mutation … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Pre-T cell receptor for improved expansion of TCR alpha disrupted T cells
Authors: Roman Galetto, Céline Lebuhotel, Laurent Poirot, Cécile Schiffer-Mannioui, Sylvain Arnould, Julianne Smith, Andrew Scharenberg
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Recent data have emerged from adoptive T-cell therapies where exogenous expression of a chimeric antigen receptor (CAR) has been shown to confer cancer recognition on autologous T cells. However, the ability to apply this technology in an allogeneic setting would permit the
Sensitivity of lymphocytes from patients with systemic lupus erythematosus to the induction of sister chromatid exchanges by alkylating agents and bromodeoxyuridine.
Authors: R.G Palmer, C.A Smith-Burchnell, C.J Doré, A.M Denman
Journal: Annals of the Rheumatic Diseases (1987)

Several authors have suggested that the cells of patients with systemic lupus erythematosus (SLE) have defects of DNA repair. Cells from patients with the classical chromosomal instability syndromes, thought to be due to defects in DNA repair, are hypersensitive to the chromosome damaging effects of some DNA damaging agents, measured as sister chromatid exchange (SCE). We have observed that lymphocytes of patients with SLE are not more sensitive than lymphocytes from healthy individuals to the SCE inducing effects of the DNA damaging agents methyl nitrosourea, methyl methanesulphonate, chlorambucil, and bromodeoxyuridine. These observations do not support the suggestion that cells of patients with SLE have an underlying defect of DNA repair.
Computed Tomography and Scintigraphy of Aldosteronoma
Authors: KIKUO MACHIDA, JUNICH NISHIKAWA
Journal: Clinical Nuclear Medicine (1983)

Twelve cases of aldosteronoma were evaluated with CT and radioisotope scintigraphy to compare the diagnostic capability of both methods. All cases were diagnosed with scintigraphy, while six of 12 cases were diagnosed with CT. However, considering that nuclear imaging requires seven or eight days for evaluation, and the radiation dose is relatively high, it seems reasonable to perform CT scans initially in the localization of an aldosteronoma and to include scintigraphy in those cases in which aldosteronoma is not demonstrated by CT.
Effect of preoperative anaesthetic visit on anxiety.
Authors: J M Leigh, J Walker, P Janaganathan
Journal: BMJ (1977)

Anxiety levels measured in patients who received preoperative reassurance about anaesthesia from a member of the hospital staff were significantly lower than those in a control group given no such support. Anxiety levels in patients who read a booklet designed to reassure about anaesthesia were less significantly reduced. Owing to the increasing work load in the operating theatre many anaesthetists can no longer afford the time to visit patients preoperatively. This study shows that either this trend should be reversed or the role of reassurer should be assumed by someone else, possibly the anaesthetic nurse. For optimal effect, the visits should be combined with use of the booklet. Unless such measures are taken, up to three million people each year may be being denied any form of reassurance before surgical treatment.