Clozapine-related Pancreatitis
Authors: Pada Jubert
Journal: Annals of Internal Medicine (1994)

Letters1 November 1994Clozapine-related PancreatitisPada Jubert, MDPada Jubert, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-9-199411010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Clozapine, an atypical antipsychotic drug, has some well-known adverse reactions [1]. The most important is agranulocytosis, which necessitates regular monitoring of leukocyte counts. This agent has also been associated with gastrointestinal complications, but, to our knowledge, only two cases of pancreatitis have been reported [2, 3]. We report a new case of pancreatitis related to an acute overdosage of clozapine.A 63-year-old woman with a history of dysthymic disorder and a personality disorder with histrionic traits attempted suicide by ingesting more than 1000 mg of clozapine—a drug that had been used to treat chronic schizophrenia in her ...References1. Baldessarini RJ, Frankenburg FR. Clozapine: a novel antipsychotic agent. N Engl J Med. 1991; 324:746-54. Google Scholar2. Martin A. Acute pancreatitis associated with clozapine use (Letter). Am J Psychiatry. 1992; 149:714. Google Scholar3. Frankenburg FR, Kando J. Eosinophilia, clozapine and pancreatitis (Letter). Lancet. 1992; 340:251. Google Scholar4. Bourgeois JA, Drexler KG, Hall MJ. Hypersalivation and clozapine (Letter). Hosp Community Psychiatry. 1991; 42:1174. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrug induced pancreatitis: A systematic review of case reports to determine potential drug associationsRecurrent pancreatitis without eosinophilia on clozapine rechallengeRisperidone-Induced Hyperamylasemia, Hyperlipasemia, and Neuroleptic Malignant SyndromeClozapine: Acquittal of the usual suspectDrug-Induced PancreatitisDrug-Induced Acute Pancreatitis: An Evidence-Based ReviewRisperidone and PancreatitisPancreatitis Associated With Quetiapine UseTherapeutic Options in the Treatment of Clozapine-Induced Adverse EffectsAtypical antipsychotics and diabetes mellitusPancreatitis Associated with Atypical Antipsychotics: From the Food and Drug Administration’s MedWatch Surveillance System and Published ReportsThe development of a clinical syndrome of asymptomatic pancreatitis and eosinophilia after treatment with clozapine in schizophrenia: implications for clinical care, recognition and managementPancreatitis and Cholestatic Hepatitis Induced by RisperidoneNew-Onset Diabetes Mellitus and Diabetic Ketoacidosis Associated With Olanzapine TreatmentAcute pancreatitis associated with clothiapine useFeatures and Toxicokinetics of Clozapine in OverdoseClozapine overdose 1 November 1994Volume 121, Issue 9Page: 722-723KeywordsAbdominal painAntidepressantsBilirubinComaDrugsLipasesPancreatitisResearch laboratoriesSuicideVentilators Issue Published: 1 November 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...