tbuckley/cabot-search huggingface dataset:
Deterioration of Myocardial Function Following Aorto-Coronary Bypass Operation
Authors: RICHARD L. SHEPHERD, SAMUEL B. ITSCOITZ, D. LUKE GLANCY, EDWARD B. STINSON, ROBERT L. REIS, GORDON N. OLINGER, CHESTER E. CLARK, STEPHEN E. EPSTEIN
Journal: Circulation (1974)

Twenty-two patients underwent cardiac catheterization before and an average of five months after aorto-coronary bypass operation (ACBO). Two groups were examined: 10 patients with all grafts patent, and 12 patients with one or more grafts occluded. All patients improved symptomatically, regardless of graft patency. However, in the occluded group, left ventricular end-diastolic pressure (LVEDP) increased (4.4 ± 2.2 mm Hg, P &lt; 0.05), stroke volume index fell (9.8 ± 3.1 ml/m 2 , P &lt; 0.05), ejection fraction decreased (10 ± 4%, P &lt; 0.05), and left ventricular stroke work index fell (12 ± 3 g-m/m 2 , P &lt; 0.01). Qualitative analysis of segmental left ventricular contractility was performed. Of 28 segments supplied by patent grafts, six improved and nine deteriorated. Of 22 segments supplied by occluded grafts, none improved and eight deteriorated. Frequently no angiographically demonstrable basis for the segmental deterioration was evident. We concluded that while ACBO may appreciably benefit severely symptomatic patients, our results do not substantiate the claim that ACBO should be recommended when the primary surgical goal is preservation or enhancement of myocardial function.
Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking.
Authors: H A Lehr, A S Weyrich, R K Saetzler, A Jurek, K E Arfors, G A Zimmerman, S M Prescott, T M McIntyre
Journal: Journal of Clinical Investigation (1997)

Cigarette smoking within minutes induces leukocyte adhesion to the vascular wall and formation of intravascular leukocyte-platelet aggregates. We find this is inhibited by platelet-activating factor (PAF) receptor antagonists, and correlates with the accumulation of PAF-like mediators in the blood of cigarette smoke-exposed hamsters. These mediators were PAF-like lipids, formed by nonenzymatic oxidative modification of existing phospholipids, that were distinct from biosynthetic PAF. These PAF-like lipids induced isolated human monocytes and platelets to aggregate, which greatly increased their secretion of IL-8 and macrophage inflammatory protein-1alpha. Both events were blocked by a PAF receptor antagonist. Similarly, blocking the PAF receptor in vivo blocked smoke-induced leukocyte aggregation and pavementing along the vascular wall. Dietary supplementation with the antioxidant vitamin C prevented the accumulation of PAF-like lipids, and it prevented cigarette smoke-induced leukocyte adhesion to the vascular wall and formation of leukocyte-platelet aggregates. This is the first in vivo demonstration of inflammatory phospholipid oxidation products and it suggests a molecular mechanism coupling cigarette smoke with rapid inflammatory changes. Inhibition of PAF-like lipid formation and their intravascular sequela by vitamin C suggests a simple dietary means to reduce smoking-related cardiovascular disease.
960. Forced Expression of the Heat Shock Protein H11 Causes Growth Arrest and Apoptosis of Melanoma Cells through TAK1 Activation and Inhibits Tumor Growth in Xenograft Models
Authors: Baiquan Li, Cynthia C. Smith, Jennifer M. Laing, Laure Aurelian
Journal: Molecular Therapy (2006)

The newly cloned small heat shock protein H11 evidences cell- type specific silencing by aberrant DNA methylation in 5/9 melanoma cell lines. In these cells, the de-methylating agent Aza-C causes H11 overload and triggers growth arrest and apoptosis. Apoptosis is blocked by antisense, but not sense, H11 oligonucleotides, indicating that it is induced by H11. Aza-C treatment did not induce H11 expression nor trigger growth arrest/apoptosis in cultured normal melanocytes. To identify the mechanism of growth arrest/apoptosis induced by H11 overload, melanoma cells were stably transfected with H11 under the control of a tetracycline sensitive promoter and examined for altered gene expression and cell survival before and after treatment with Doxycycline (Dox). Dox (2 μg/ml) caused a time-dependent increase in H11 expression, reaching maximal levels on day 3 post treatment. H11 overload was accompanied by growth arrest (first seen on days 1-2 post Dox), activation of caspases-9 and-3, seen as early as day 1 post Dox and a time-dependent increase in the% TUNEL+ (apoptotic) cells (70-85% on days 3-4 post Dox). Immunoprecipitation/immunoblotting and immunocomplex PK assays indicated that H11 bound and activated TAK1. TAK1 did not bind and was not activated by the H11 mutant, W51C which is dominant negative for apoptosis. Caspase activation was inhibited with the dominant negative TAK1 mutant K63W or the p38MAPK pharmacologic inhibitor SB203580, indicating that apoptosis is caused by H11-mediated activation of the TAK1/p38MAPK pathway. H11-mediated growth arrest was also caused by activated TAK1, through phosphorylation of b-catenin and inhibition of MITF and CDK2, which are required for melanoma cell proliferation. H11 did not bind nor activate TAK1 in normal melanocytes. Studies of the highly tumorigenic A2058 and LM melanoma cultures in a mouse xenograft model, indicated that tumor growth was significantly (p<0.001) reduced by treatment with Aza-C (5mg/kg) given by ip injection on days 6 and 15 after initiation of the xenografts (3 doses at 3hr intervals). Decreased tumor growth was due to H11 induced apoptosis as evidenced by H11/TUNEL co-localization in residual tumor cells. The data suggest that H11 is a promising target for chemogene therapy of melanoma and identify additional members of the H11-mediated pro-apoptotic cascade.
Thrombosis associated with <scp>l</scp>‐asparaginase therapy and low fibrinogen levels in adult acute lymphoblastic leukemia
Authors: Garth Beinart, Lloyd Damon
Journal: American Journal of Hematology (2004)

L-asparaginase is a chemotherapeutic agent commonly used in the treatment of both adult and pediatric acute lymphoblastic leukemia (ALL). A major complication is thrombosis, resulting from reduced synthesis of proteins such as antithrombin III. Hypofibrinogenemia, also a side effect, may be a marker of thrombosis and decreased protein synthesis. A retrospective chart review of identically treated patients revealed 9 thrombotic events among 93 patients (10%), 6 (7%) occurring during treatment cycles including L-asparaginase. Twelve (13%) patients had fibrinogen levels <50 mg/dL. Of these, 3 (25%) suffered a thrombotic event. This results in a specificity of 90% and a relative risk of 10 (P = 0.014). Therefore, a fibrinogen <50 mg/dL may serve as a marker for a hypercoagulable state in ALL patients receiving L-asparaginase.
Men's life expectancy is catching up with women's
Authors: Madeleine Brettingham
Journal: BMJ (2005)

The historic gap between men and women's life expectancy could vanish as more and more women accustom themselves to the work hard-play hard culture of modern Britain, new figures from the Office of Health Economics show.

The rise of women in the workplace and the increasing prevalence of heavy drinking among women are leaving more women than ever vulnerable to illnesses traditionally experienced by men, the office's Compendium of Health Statistics says.



Although traditionally lower, male life expectancy is rising at a faster rate …
Impact of the environment on reproductive health: executive summary.
Authors: F Michal, K M Grigor, A Negro-Vilar, N E Skakkebaek
Journal: Environmental Health Perspectives (1993)

The papers presented at the workshop on the "Impact of the Environment on Reproductive Health" are published in this issue of the EHP Supplements. After the formal presentation of the papers, the authors and scientists met to discuss the important aspects of environmental issues affecting human reproductive health. This Executive Summary was compiled by the organizers and editors of the workshop and the proceedings.
740-2 The Impact of Heart Rate on Cerebral Blood Flow in Patients with Chronic Fatigue, Dizziness and Episodic Weakness After Implantation of Permanent Pacing Devices
Authors: Andreas Hagendorff, Christian Dettmers, Luciano Pizzulli, Heyder Omran, Alexander Hartmann, Berndt Lüderitz
Journal: Journal of the American College of Cardiology (1995)
TCT-591 Stent coverage and neointimal maturity in a randomized trial of limus-eluting stents with biodegradable polymer versus permanent polymer coatings assessed by optical coherence tomography
Authors: Tomohisa Tada, Robert Byrne, Salvatore Cassese, Antonios Dimopoulos, Michael Joner, Adnan Kastrati, Lamin King, Yi Li, Erion Xhepa
Journal: Journal of the American College of Cardiology (2013)
Atypical mycobacterial infection of the lung in rheumatoid arthritis.
Authors: S W Watkin, R C Bucknall, M Nisar, R A Agnew
Journal: Annals of the Rheumatic Diseases (1989)

AbstractMycobacterium kansasii was isolated from a cavitating pneumonia found in a 51 year old man with seropositive rheumatoid arthritis, and treatment was complicated by drug induced neuropathy.
Alimentary Lipemia, Postprandial Triglyceride-Rich Lipoproteins, and Common Carotid Intima-Media Thickness in Healthy, Middle-Aged Men
Authors: Susanna Boquist, Giacomo Ruotolo, Rong Tang, Johan Björkegren, M. Gene Bond, Ulf de Faire, Fredrik Karpe, Anders Hamsten
Journal: Circulation (1999)

Background —Alimentary lipemia has been associated with coronary heart disease and common carotid artery intima-media thickness (IMT). This study was designed to investigate the relations of subclasses of postprandial triglyceride-rich lipoproteins (TRLs) with IMT. Methods and Results —Ninety-six healthy 50-year-old men with an apolipoprotein (apo) E3/E3 genotype underwent an oral fat tolerance test and B-mode carotid ultrasound examination. The apo B-48 and apo B-100 contents of each fraction of TRLs were determined as a measure of chylomicron remnant and VLDL particle concentrations. In the fasting state, LDL cholesterol ( P &lt;0.05) and basal proinsulin ( P &lt;0.05) were significantly related to IMT, whereas HDL cholesterol, plasma triglycerides, and insulin were not. In the postprandial state, plasma triglycerides at 1 to 4 hours ( P &lt;0.01 at 2 hours), total triglyceride area under the curve (AUC) ( P &lt;0.05), incremental triglyceride AUC ( P &lt;0.01), and the large VLDL (Sf 60 to 400 apo B-100) concentration at 3 hours ( P &lt;0.05) were significantly related to IMT. Multivariate analyses showed that plasma triglycerides at 2 hours, LDL cholesterol, and basal proinsulin were consistently and independently related to IMT when cumulative tobacco consumption, alcohol intake, waist-to-hip circumference ratio, and systolic blood pressure were included as confounders. Conclusions —These results provide further evidence for postprandial triglyceridemia as an independent risk factor for early atherosclerosis and also suggest that the postprandial triglyceridemia is a better predictor of IMT than particle concentrations of individual TRLs.
Abstract P6-10-06: Rational combination therapy against triple-negative breast cancer
Authors: F Al-Ejeh, M Miranda, PT Simpson, G Chenevix-Trench, SR Lakhani, KK Khanna
Journal: Cancer Research (2012)

Abstract Background: Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with higher incidence of recurrence, more distant metastasis, and poorer survival. This subtype is also characterized by complex genomes where little of their genomes remain at normal copy number but without high, focal copy number amplifications. At the transciptome level, the majority of TNBC (∼75%) are classified as basal-like breast cancer (BLBC) according to the five intrinsic subtypes. Despite considerable genomic and gene expression characterization of TNBC, proteomic and phospho-proteomic investigations of this disease are limited with no available targeted therapies in clinical use. Methods &amp; Results: We used the Kinex™ antibody array (http://www.kinexus.ca/) to interrogate protein/phosphoproteins levels in 43 primary breast cancer biopsies (16 TNBC, 16 ER/PR positive and 11 HER2-positive) and 16 breast cancer cell lines. Unsupervised hierarchical clustering of protein/phosphoprotein levels revealed two subgroups of TNBC in comparison to other subtypes. Western blotting and Proteome Profiler™ Arrays (R&amp;D Systems) were used to validate deregulated proteins/phosphoproteins in TNBC. Pathway analysis revealed that one subgroup of TNBC exploits overlapping and cross-talking networks for survival. These signaling networks are downstream from elevated activation of EGFR, integrins and Insulin-like growth factor 1 receptor (IGF1R). Targeted molecular inhibitors of activated kinases in these pathways showed specificity against basal-like/TNBC cell lines compared to other subtypes in vitro. These activated kinases/networks represent druggable targets for the treatment of TNBC but may be limited by compensatory effect of the complex cross-talking signaling networks. To overcome compensatory downstream signaling that would limit the inhibition of a given pathway; we developed EGFR-targeted radioimmunotherapy (RIT) strategy to systemically deliver cytotoxic loads of beta particles (177Lu) that would kill targeted cells and surrounding cells by crossfire effect. The combination of EGFR-directed RIT with chemotherapy and PARP inhibition successfully treated orthotopic and metastatic TNBC models established from cell lines and patient-derived xenografts. The superior efficacy of this triple-agent combination therapy is explained by enhanced DNA damage and reduced DNA repair response, higher apoptotic cell death and the elimination of putative breast cancer stem cells. Conclusion: Proteomic analysis of TNBC provides a powerful tool to elucidate druggable signaling networks with therapeutic potential. TNBC utilizes complex interacting signaling networks and rational combination therapies are required for effective therapy. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P6-10-06.
Colchicine stimulates the rate of contraction of heart cells in culture
Authors: I. KLEIN
Journal: Cardiovascular Research (1983)

Journal Article Colchicine stimulates the rate of contraction of heart cells in culture Get access IRWIN KLEIN IRWIN KLEIN From the Department of Medicine, University of Pittsburgh School of Medicine Pittsburgh, PA 15261 and the Veterans Administration Hospital Pittsburgh, PA 15240 Address all communications to: Irwin Klein, MD, University of Pittsburgh School of Medicine, 961 Scaife Hall, Pittsburgh, PA 15261, USA. (412) 624-3605. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 17, Issue 8, August 1983, Pages 459–465, https://doi.org/10.1093/cvr/17.8.459 Published: 01 August 1983
The pustular skin lesions in Behcet's syndrome are not sterile
Authors: G Hatemi
Journal: Annals of the Rheumatic Diseases (2004)

The pustular skin lesions of Behcet's syndrome (BS) are clinically and histopathologically similar to ordinary acne, but BS patients get lesions at sites not commonly involved in acne, such as the legs and arms. The microbiology of these lesions has not been studied adequately.To make a detailed study of the microbiology of BS lesions.Subjects were patients with BS and acne vulgaris. Material was extracted from pustular lesions and directly plated to aerobic and anaerobic media by sterile swab. Anaerobic bacteria were identified using a commercial kit (API 20A). Aerobic bacteria were defined by standard procedures.58 BS patients and 37 acne patients were studied. Pustules were cultured from the following sites: BS patients (70 pustules): face (17), back (30), chest (2), arm (4), leg (17); acne patients (37 pustules): face (27), back (6), chest (1), arm (2), leg (1). At least one type of microorganism was grown from each pustule. Staphylococcus aureus (41/70, 58.6%, p = 0.008) and Prevotella spp (17/70, 24.3%, p = 0.002) were significantly more common in pustules from BS patients, and coagulase negative staphylococci (17/37, 45.9%, p = 0.007) in pustules from acne patients.The pustular lesions of BS are not usually sterile. The microbiology of these lesions is different from ordinary acne. It remains to be determined whether the infection is secondary or has any pathogenic implications.
Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly–capillary malformation syndrome
Authors: Laura M McDonell, Ghayda M Mirzaa, Diana Alcantara, Jeremy Schwartzentruber, Melissa T Carter, Leo J Lee, Carol L Clericuzio, John M Graham, Deborah J Morris-Rosendahl, Tilman Polster, Gyula Acsadi, Sharron Townshend, Simon Williams, Anne Halbert, Bertrand Isidor, Albert David, Christopher D Smyser, Alex R Paciorkowski, Marcia Willing, John Woulfe, Soma Das, Chandree L Beaulieu, Janet Marcadier, Michael T Geraghty, Brendan J Frey, Jacek Majewski, Dennis E Bulman, William B Dobyns, Mark O'Driscoll, Kym M Boycott
Journal: Nature Genetics (2013)
THE MEDICAL TREATMENT OF APPENDICITIS.
Authors: ELMER LEE
Journal: JAMA (1898)

There are no new truths, but there may be new phases of that which is old. Progress means the development of new applications through invention and study. Onward and upward is the direction in which the scientific world moves, and no one dares forestall the possibility of discovery in medicine that awaits the higher intelligence. The bases of the unknown triumphs which will be the happy surprises for the future have their preparations in the knowledge and handiwork of the present. The tools increase in delicacy, and number and become more and more adapted to the work of attaining the ideal of crafty man. Methods of using old forces for pleasure or service in the arts and the sciences have greatly changed, and the evolution is for good. The betterment is often a question for doubt by the pessimists, but judged from the standpoint of the universe, not by the
IMPROVEMENT OF SEVERE ANEMIA IN PATIENTS WITH AORTIC STENOSIS COMPLICATED WITH GASTROINTESTINAL BLEEDING FROM ANGIODYSPLASIA (HEYDE’S SYNDROME) AFTER AORTIC VALVE REPAIR
Authors: Tomohisa Tada, Toshihiro Tamura, Junichi Tazaki, Toshikazu Jinnai, Neiko Ozasa, Satoshi Shizu, Ko Ono, Hisanori Horiuchi, Takeshi Kimura Kimu
Journal: Journal of the American College of Cardiology (2010)
Potential role for concurrent abnormalities of the cyclin D1, p16CDKN2 and p15CDKN2B genes in certain B cell non-Hodgkin’s lymphomas. Functional studies in a cell line (Granta 519)
Authors: DM Jadayel, J Lukas, E Nacheva, J Bartkova, G Stranks, PJJC De Schouwer, D Lens, J Bartek, MJS Dyer, AR Kruger, D Catovsky
Journal: Leukemia (1997)
The Innate Immune Receptor Nod1 Protects the Intestine from Inflammation-Induced Tumorigenesis
Authors: Grace Y. Chen, Michael H. Shaw, Gloria Redondo, Gabriel Núñez
Journal: Cancer Research (2008)

Abstract There is growing evidence that the host innate immune system has a critical role in regulating carcinogenesis, but the specific receptors involved and the importance of their interaction with commensal bacteria need to be elucidated. Two major classes of innate immune receptors, the Toll-like receptors and Nod-like receptors, many of which are upstream of nuclear factor-κB, are involved in the detection of intestinal bacteria. The Toll-like receptors have been implicated in promoting colon tumorigenesis, but the role of Nod-like receptors in regulating tumorigenesis remains unclear. Using an established mouse model system of colitis-associated colon tumorigenesis, we show that Nod1 deficiency results in the increased development of both colitis-associated and Apc tumor suppressor–related colon tumors. In the absence of Nod1 signaling, there is a greater disruption of the intestinal epithelial cell barrier due to chemically induced injury as manifested by increased surface epithelial apoptosis early on during chemically induced colitis and increased intestinal permeability. The increased intestinal permeability is associated with enhanced inflammatory cytokine production and epithelial cell proliferation in Nod1-deficient mice as compared with wild-type mice. Depletion of the gut microbiota suppressed tumor development in Nod1-deficient mice, thus highlighting a link between the commensal bacteria within the intestine and the host innate immune Nod1 signaling pathway in the regulation inflammation-mediated colon cancer development. [Cancer Res 2008;68(24):10060–7]
A Community-Wide Study of Acute Rheumatic Fever in Adults
Authors: Leon Gordis, Abraham M. Lilienfeld, Romeo Rodriguez
Journal: JAMA (1969)

In Baltimore from 1960 to 1964, 18% of all patients hospitalized for acute rheumatic fever were adults. The average annual incidence of hospitalizations for acute rheumatic fever in adults aged 20 to 39 years was 3.1 per 100,000, approximately one fifth the rate in children and adolescents in the same community. Incidence rates were higher among nonwhites than whites, particularly for recurrent attacks. None of the adults with a recurrence was receiving regular prophylaxis at the time of his attack. Seven of the 12 patients with recurrences had no history of clinical symptoms relating to prior upperrespiratory tract infection. The data indicate that both initial and recurrent attacks of acute rheumatic fever continue to occur in adults, and emphasize the importance of maintaining continuous antistreptococcal prophylaxis in the young adult rheumatic population.
A Stress Analysis of a Strapless Evening Gown and Other Essays for a Scientific Age
Authors: Sigmund L. Wilens
Journal: JAMA (1964)

Many scientists lead lives of quiet exasperation; at times a few are impelled to break the silence. In this volume Baker has compiled an impressive, if variegated, array of satirical compositions on the scientific scene. Each article, if read at a convention banquet or annual Sigma Xi dinner, would have been a riot; strung together in an anthology, some still retain their humorous bite. In many, however, the whimsy has withered or curdled, while a few are about as unappealing as sphaceli on a surgical sponge. A<i>boutade</i>on<i>décolletage</i>provides the collection with its provocative name. The contents of this particular paper prove to be less inspired than the title, a not unfamiliar failing of many scientific communications. It is clear, however, that with the aid of engineering principles, the mammary appendage has defied the laws of gravity more successfully than did the apple of Newton. In another essay,