tbuckley/cabot-search huggingface dataset:
Abstract 4602: Effect of estrogen receptor antagonistic drugs on expression and regulation of fatty acid synthase (FAS) in ER+ breast cancer cell lines
Authors: Mohammad S. Atefi, Cristina Zheng, Zahra Atefi, Dennis J. Slamon
Journal: Cancer Research (2010)

Abstract Expression of estrogen receptor (ER) is detected in more than sixty percent of breast tumors. High levels of Fatty acid synthase (FAS) have been detected in aggressive breast cancers. Due to its high level of expression, FAS has been considered as a tumor marker and a therapeutic target. In normal rat liver, increase in expression of FAS requires glucose and a combination of hormones. Activity of FAS is indirectly regulated by the upstream signaling factor AMPK. AMPK is considered to be the main regulator of cellular metabolism. Upon activation, AMPK down regulates FAS activity and other ATP consuming pathways. In this study, we investigated the possible regulatory role of estrogen receptor (ER) signaling on FAS level and activity. In a panel of ER+ cell lines, very high levels of FAS expression was observed in the majority of the cell lines. The highest levels of FAS were in the ER+/HER2+ cell lines, HCC1419, BT474 and MDA-MB-361, respectively. However, in two other ER+/HER2+ cell lines, UACC732 and UACC812, the expression was similar to or even lower than the HER2 negative cell lines. Three HER2 negative cell lines in the panel also showed very high levels of FAS expression. Upon incubation of the cells in the absence of serum and phenol red condition, a general decrease in the FAS levels was observed that was more evident in HER2 negative cell lines. In the same condition, the effects of ER inhibitory drugs, fulvestrant and tamoxifen, on FAS and p-AMPKα levels were investigated. In ER+ cell lines that contain high levels of p-AKT, ER inhibitors did not affect levels of FAS and p-AMPKα. However, in some cell lines with lower levels of active AKT, tamoxifen and fulvestrant induced changes in FAS and p-AMPKα levels that were variable from cell line to cell line. In MCF-7 cell line, which is highly sensitive to ER inhibitors, both tamoxifen and fulvestrant induced lower FAS and higher p-AMPKα levels. Contrary to this observation, tamoxifen induced higher FAS and lower p-AMPKα levels in T-47D and KPL-1 cell lines. Fulvestrant induced a similar effect in ZR-75-1 cell line. This inducing effect of ER antagonists on FAS perhaps reflects one of the mechanisms that cause the elevation of blood lipids in post menopausal and tamoxifen treated women. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4602.
MODY
Authors: Stefan S. Fajans, Graeme I. Bell
Journal: Diabetes Care (2011)

Studies conducted at the University of Michigan for 60 years and at the University of Chicago for approximately 25 years form the basis of this review. As no field of study can develop or progress in isolation, we have included selected investigations performed in other centers.

In the academic year 1949–1950, one of us (S.S.F.), while a first-year Fellow in Endocrinology and Metabolism at the University of Michigan (Jerome W. Conn, Division Chief), initiated a prospective, long-term study on the diagnosis, natural history, and clinical genetics of diabetes. Starting with known diabetic patients from the Diabetes Clinic, I recruited their apparently healthy and asymptomatic first-degree relatives (parents, brothers, sisters, and children) for routine oral glucose tolerance tests (OGTTs). As control subjects, I recruited young individuals, many of them students, physicians, nurses, dietitians, and their spouses, who did not have a family history of diabetes or of large newborn babies. The initial objectives were 1 ) to define the normal range for the OGTT, 2 ) to attempt to unmask the potential diabetic subjects who manifest normal glucose tolerance by the standard OGTT and determine whether the diabetogenic activity of cortisone could be used to uncover a subclinical defect in the metabolism of glucose, and 3 ) to carry out periodic follow-up over many years of the apparently healthy first-degree relatives of diabetic patients. In our first publication in 1954 (1), 19% of 152 relatives of known diabetic patients were found to have diabetes by OGTT and, moreover, some were as young as 10 years of age. The same prevalence of 19% was found when testing a larger sample of 438 relatives of known diabetic patients (2).

In 1960, we reported that mild, asymptomatic diabetes occurs in nonobese children, adolescents, and young adults. Their diabetic glucose tolerance and fasting hyperglycemia improved or normalized …
Clinical Value of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography in Differentiation of Malignant Mesothelioma from Asbestos-Related Benign Pleural Disease: An Observational Pilot Study
Authors: Huseyin Yildirim, Muzaffer Metintas, Emre Entok, Guntulu Ak, Ilknur Ak, Emine Dundar, Sinan Erginel
Journal: Journal of Thoracic Oncology (2009)
Psychoendocrine Study of Oral Contraceptive Agents
Authors: FRANCIS J. KANE, MORRIS A. LIPTON, ALBERT R. KRALL, PAUL A. OBRIST
Journal: American Journal of Psychiatry (1970)

To determine if there was risk of adverse reaction to oral contraceptives, the authors conducted a two-month single-blind study of seven women, who received a combination agent or a sequential agent. All subjects reported affective symptoms; however, significant changes appeared in only one patient, who was the most clinically disturbed. Catecholamine excretion was altered in all patients. From their findings and the literature, the authors speculate that use of such drugs that alter catecholamine metabolism will result in behavioral change, especially in users who have had prior depressive illness.
Time for treatment targets in rheumatoid arthritis
Authors: P. Emery
Journal: BMJ (2010)

Binder and Ellis’s article on investigating symmetrical polyarthritis is pertinent to recent developments in managing rheumatoid arthritis.1 The recently published international “treat to target” recommendations for rheumatoid arthritis are an opportunity to examine the outcomes for UK patients against established and professional guidance.2 The goal should be remission or low disease activity only if …
Detection of Epstein-Barr virus in cutaneous and lymph nodal anaplastic large cell lymphomas (Ki-l+)
Authors: K. PERIS, H. NIEDERMEYER, S. CHIMENTI, T. RADASKIEWICZ, H. KERL, H. HOEFLER
Journal: British Journal of Dermatology (1995)

Epstein‐Barr virus (EBV) is a gamma DNA herpes virus which is thought to play a part in the pathogenesis of some non‐Hodgkin's lymphomas in individuals with or without immunodeficiency. We investigated 16 lymph nodal and 12 cutaneous anaplastic large cell lymphomas (ALCLs) (Ki‐1 +), all of which were in patients without immunodeficiency, for the presence of EBV genomes. The highly sensitive polymerase chain reaction (PCR) technique was employed for detection of viral DNA in extracts from formalin‐fixed, paraffin‐embedded tissue sections. In addition, we performed radioactive and non‐radioactive in situ hybridization (ISH) for localization of EBV at the single cell level. EBV‐DNA was demonstrated by PCR in five cases of nodal ALCLs (31 %). All cutaneous ALCLs were negative. EBV‐encoded small nuclear RNAs (EBERs) could be identified by ISH in the tumour cells of one of the five EBV‐DNA‐positive patients. Our results further support the concept that EBV may be involved in the development of a proportion of nodal ALCLs, hut not in cutaneous ALCLs.
The Biology of Myocardial Infarction
Authors: GUNNAR BIÖRCK
Journal: Circulation (1968)

Myocardial infarction is a dreaded companion of the civilization of our time. The "heart attack," the coronary thrombosis, the myocardial infarction lurk behind the corner, striking strangers, patients, friends, and ourselves. The toll taken by this single "disease" in many hospitals equals or even exceeds that from almost all other diseases together. Must it be so? This is the question many physicians, and the lay public, are asking themselves today. Identification of some areas where our knowledge is particularly deficient is stressed. We must concentrate our efforts on reevaluating practices and procedures that have brought both the greatest success and the worst failures, at the same time that we ask ourselves what goals could be considered realistic. If myocardial infarction is the evil of our time, what does this mean in a greater biological context-in the evolution of human life and endeavor as viewed in perspective? Are we dealing with a "disease" in the restricted sense of the word, or are we dealing with a way of life and a consequent mode of death? If so, what can be done to achieve the goals of health as defined by the World Health Organization? In what terrain are the forces to be assembled and the battle to be fought-and by whom.
The Complementary Role of SPECT in the Diagnosis of Cavernous Hemangioma of the Liver
Authors: SABAH S. TUMEH, ROBERT J. ENGLISH, B LEONARD HOLMAN
Journal: Clinical Nuclear Medicine (1985)

Cavernous hemangiomas are the most common benign tumors of the liver. Although their clinical course is usually uncomplicated, an accurate diagnosis may be important to exclude conditions that need treatment, (or to avoid an unnecessarily risky percutaneous biopsy). Although blood pool scintigraphy using planar gamma camera imaging is a reliable examination for the diagnosis of liver hemangiomas, it may fail to depict small, deeply seated lesions, and hence miss the diagnosis. Two cases are reported in which SPECT demonstrated delayed pooling in small, deep, space-occupying lesions, which were poorly seen on planar images, and therefore made a cavernous hemangioma the most likely diagnosis.
CASE OF LITHOTOMY
Authors: W. T. Bell
Journal: BMJ (1856)

tnued, and I orded a small portion of the following oint- ment to be rubbed in over the st of pain, night and & Unguenti hydrargyri fortioris,unguenti camphorse, &aSss; extraoti belladonnie gr.iv.Fiat unguentum.June 6th.(Her sister was married on this day.)She had a violent hysterical attack, which gave way to the usual remedies, quiet and opium.Pulse 96; rather better in character, but still feeble.The ointment was ordered to be continued.June 9th.Pain diminished; she was able to sit in a chair comfortably for the first time.June 13th.She had a slight hysterical attack for half an hour, which subsided without medical interference.June 20th.The abdominal pain had materially abated, indeed was not perceptible, except on pressure over the part.Her appetite had been failing for the last two or three days,'and she complained of a feeling of heat at the stomach.Continue the ointment.& Potassu bicarb. 5ij; acidi citrici 3 iss; acidi hydro- cyanici diluti mkxij; aqume destillati ad 3vj.Fiat mist.Capiat ~j ter quotidie.
467 LONGTERM BENEFITS OF SUSTAINED VIROLOGICAL RESPONSE (SVR) IN PATIENTS WITH CHRONIC HEPATITIS C (CHC) VIRUS INFECTION: THE GERMAN LOTOS STUDY
Authors: J. Reimer, D. Hueppe, P. Sandow, U. Naumann, J. Goelz, S. Christensen, H. Busch, T. Lutz, K.-H. Hey, K. Gruengreiff, M. Leuschner, G. Feiten, B. Bokemeyer, G. Bellmann, R. Link, S. Stoll, H. Wedemeyer
Journal: Journal of Hepatology (2011)
1002-83 In Utero Pulmonary Outflow Obstruction: Natural History and Predictors of Postnatal Severity
Authors: Lisa K. Hornberger, Philip J. Spevak, Robert W. McDonald, Mary J. Rice, Gerard R. Martin, Stephen P. Sanders, Steven D. Colan, David J. Sahn
Journal: Journal of the American College of Cardiology (1995)
Measurement of blood pressure in children.
Authors: P. H. Whincup, D. G. Cook, A. G. Shaper
Journal: BMJ (1989)

A further important point is that 20-30% of the population in the Paddington and North Kensington area is not registered with a general practitioner and would therefore not be included in any screen- ing programme that is based on the family practi- tioner committee register.This is a cause of some concern and necessitates the implementation of alternative strategies, which bear an additional cost.
Cytokine production if circulating lymphocytes from children treated for wheezing in the emergency department (ED)*1
Authors: M.S. Shaker, H.T. Carper, W. Woods, L. Borish, J.F. Hunt, F.G. Hayden, T.A.E. Platts-Mills, P.W. Heymann
Journal: Journal of Allergy and Clinical Immunology (2004)
TV: Doctors find an ally
Authors: A. Ferriman
Journal: BMJ (2001)

At last, some good news. After months of feeling vilified as arrogant, paternalistic, and insensitive, doctors have found an ally. The Broadcasting Standards Commission, which regulates television and radio broadcasts, has just upheld two complaints against programme makers for unfair treatment of doctors. Finally, an adjudicating authority has been prepared to say enough is enough.

This victory does not relate to the most recent battles over retention of organs, botched gynaecological operations, or MMR vaccinations, however. It relates to the longstanding acrimony between parents accused of child abuse and the doctors who try to ensure that children are not abused.

The first complaint involved an edition of Panorama called “Sick and Tired,” which championed the cause of parents whose children have chronic fatigue syndrome. The message of the programme was that some misguided doctors, who saw the disorder mainly as a psychological illness, treated children with “distraction therapy” (by trying to distract the children from their symptoms) and expected them to do things that were beyond them. The most effective treatment, the programme seemed to say, was bed rest. It suggested that the medical profession was split more or less equally between those who favoured rehabilitation and those who favoured rest.

It went on to claim that if parents refused the rehabilitative treatment for their child, a coven of doctors, social …
Abstract A38: DDB2 suppresses tumorigenicity of ovarian cancer cells through reducing the subpopulation of cancer stem cells
Authors: Chunhua Han, Ran Zhao, John Kroger, Xingluo Liu, Qi-En Wang
Journal: Clinical Cancer Research (2013)

Abstract Ovarian cancer is an extremely aggressive disease associated with a high percentage of recurrence and chemotherapy resistance. Damaged DNA binding protein 2 (DDB2) is a 48-kDa protein originally identified as a component of the damage-specific DNA-binding heterodimeric complex DDB. Besides the known ability of DDB2 protein to bind ultraviolet (UV)-damaged DNA and serving as the initial damage recognition factor during nucleotide excision repair (NER). DDB2 was also reported to be involved in the promotion of apoptosis to reduce cisplatin resistance of ovarian cancer cells, control of cell migration, invasiveness and breast tumor progression, as well as suppression of metastasis of colon cancer through a transcriptional regulatory mechanism. Here we show that DDB2 overexpression in human ovarian cancer cell line CP70 suppressed its capability to recapitulate tumors in athymic nude mice, as well as the growth of these cells cultured in semisolid media. Flow cytometry analyses indicate that DDB2 overexpression in CP70 cells reduced the abundance of CD117+ cells and ALDH+ cells, which are believed to be markers of cancer stem cells (CSCs) in ovarian cancer. In contrast, downregulation of DDB2 in ovarian cancer cell line A2780 increased the percentage of ALDH+ cells. In addition, we analyzed the expression level of DDB2 in the putative CSCs isolated from various ovarian cancer cell lines, and demonstrated that DDB2 expression is decreased in the CSCs in comparison with their parental bulk tumor cells. Overexpression of DDB2 in the ovarian CSCs reduced the expression of CSC markers, e.g., Sox2 and Nanog. In addition, overexpression of DDB2 in CSCs isolated from ovarian cancer cell line SKOV-3 also decreased the tumorigenicity of these cells in NOD/SCID mice. In summary, our data suggest that DDB2 suppresses tumorigenicity of ovarian cancer cells through reducing the CSCs pool in cancer cells. Thus, increasing the expression of DDB2 may provide a molecular strategy to inhibit the recurrence of ovarian cancer. (Supported by NIH R01 grant CA151248 to QEW) Citation Format: Chunhua Han, Ran Zhao, John Kroger, Xingluo Liu, Qi-En Wang. DDB2 suppresses tumorigenicity of ovarian cancer cells through reducing the subpopulation of cancer stem cells. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr A38.
Rivaroxaban and usual care had similar rates of recurrent VTE and bleeding in symptomatic PE
Authors: Daniel M. Witt
Journal: Annals of Internal Medicine (2012)

ACP Journal Club21 August 2012Rivaroxaban and usual care had similar rates of recurrent VTE and bleeding in symptomatic PEDaniel M. Witt, PharmD, FCCP, BCPSDaniel M. Witt, PharmD, FCCP, BCPSKaiser Permanente Colorado, Aurora, Colorado, USA (D.M.W.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-4-201208210-02006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationBüller HR, Prins MH, Lensing AW, et al; EINSTEIN-PE Investigators. Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med. 2012;366:1287-97. https://pubmed.ncbi.nlm.nih.gov/22449293Clinical Impact RatingsGIM/FP/GP: Cardiology: Hematology: Pulmonology: Reference1 EINSTEIN Investigators, Bauersachs R, Berkowitz SD, et al. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med. 2010;363:2499-510. [PMID: 21128814]. Google Scholar Author, Article, and Disclosure InformationAffiliations: Kaiser Permanente Colorado, Aurora, Colorado, USA (D.M.W.)This article was published at Annals.org on 7 August 2012. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByBeinparese nach HüftendoprothesenimplantationA Review of Thrombosis and Antithrombotic Therapy in Microvascular Surgery 21 August 2012Volume 157, Issue 4Page: JC2-6KeywordsCellsHemoglobinHemorrhagePulmonary embolismPulmonary medicineResearch laboratoriesSafetyVenous thromboembolismVitamin K ePublished: 21 August 2012 Issue Published: 21 August 2012 CopyrightCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Meralgia Paresthetica and Liver Disease
Authors: GEORGE H. RADVAN
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 February 1982Meralgia Paresthetica and Liver DiseaseGEORGE H. RADVAN, M.B., PETER VIDIKAN, B.S.GEORGE H. RADVAN, M.B.Search for more papers by this author, PETER VIDIKAN, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-2-252 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Meralgia paresthetica is an entrapment neuropathy of the lateral cutaneous nerve of the thigh. The nerve crosses under the inguinal ligament at its attachment to the anterior superior iliac spine, where it angulates acutely, and then pierces the fascia lata to supply sensation to the lateral part of the thigh (1).The syndrome is characterized by a dull ache, itch, or burning sensation in the lateral thigh. Testing usually shows partial or total anaesthesia in the cutaneous distribution of the nerve. The symptoms range from minor irritation to major discomfort for the patient and treatment is generally...References1. SAUNDERLAND S. Nerves and Nerve Injuries. 2nd ed. New York: Churchill Livingstone, Inc.; 1978: 1007-10. Google Scholar2. JONES R. Meralgia paraesthetica as a cause of leg discomfort. Can Med Assoc J. 1974;111(6):541-2. Google Scholar3. RHODES P. Meralgia paraesthetica in pregnancy. Lancet. 1957;2:831. CrossrefGoogle Scholar4. STOOKEY B. Meralgia paraesthetica: aetiology and surgical treatment. JAMA. 1928;90:1705. CrossrefGoogle Scholar5. WARTENBERG R. Neuritis, Sensory Neuritis, Neuralgia: A Clinical Study with Review of the Literature. New York: Oxford University Press; 1958. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE H. RADVAN, M.B.; PETER VIDIKAN, B.S.Affiliations: University of Southern California School of Medicine Downey, CA 90242 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEntrapment Neuropathies of the Lower ExtremityNervus cutaneus femoris lateralisMeralgia Paresthetica and Large AbdomensCHAD L. DEAL, M.D., JUAN J. CANOSO, M.D. 1 February 1982Volume 96, Issue 2Page: 252-253KeywordsLigamentsLiver diseasesNervesNeuropathyPainPatientsSpine ePublished: 1 December 2008 Issue Published: 1 February 1982 PDF downloadLoading ...
Medical Practice in the Colony and Protectorate of Kenya
Authors: Gerald V. W. Anderson, Jules P. de Mello
Journal: New England Journal of Medicine (1954)

KENYA is a young and developing country. The progress made during the last eight years has been phenomenal, and medical services have shared in it. From the Capital to the most distant rural African areas the program of medical development has been going on at great speed. It has, in fact, outstripped the economic, educational and social development of the African, thus leading to heavy population pressure.In rural areas, under the auspices of the local African councils, dispensaries and maternity services have been expanding to accommodate the increasing demand due to the increasing consciousness of the indigenous population of . . .