Bone and Mineral Metabolism in Hyperthyroidism
Authors: FRANKLIN H. EPSTEIN
Journal: Annals of Internal Medicine (1968)

Editorial Notes1 February 1968Bone and Mineral Metabolism in HyperthyroidismFRANKLIN H. EPSTEIN, M.D., F.A.C.P.FRANKLIN H. EPSTEIN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-2-490 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has been known for many years that calcium and phosphorus metabolism may be profoundly disturbed in hyperthyroidism. Along with weight loss and wasting of tissues, a negative calcium balance is usual, contributed to by excessive excretion of calcium in the urine, the feces, or both (1). Hypercalcemia, usually with a normal or slightly elevated serum phosphorus, is occasionally encountered (2). Bone is the source of the excess calcium. The turnover of calcium by the skeleton is increased by thyroid hormone, and radiological signs of thinning of bone are not infrequent (3, 4).Adams and Jowsey and their colleagues (5,...References1. AUBBAUERHEATHROPES JCWCM: Studies of calcium and phosphorus metabolism. III. Effects of thyroid hormone and thyroid disease. J. Clin. Invest. 7: 97, 1929. CrossrefMedlineGoogle Scholar2. ROSEBALES ERS: Hypercalcemia in thyrotoxicosis. Med. Clin. N. Amer. 37: 1715, 1953. CrossrefGoogle Scholar3. KRANEBROWNELLSTANBURYCORRIGAN SMGLJBH: Effect of thyroid disease on calcium metabolism in man. J. Clin. Invest. 35: 874, 1956. CrossrefMedlineGoogle Scholar4. LAAKE H: Osteoporosis in association with thyrotoxicosis. Acta Med. Scand. 151: 229, 1955. CrossrefMedlineGoogle Scholar5. ADAMSJOWSEYKELLEYRIGGSKINNEGJONES PHJPJBLVRJD: Effects of hyperthyroidism on bone and mineral metabolism in man. Quart. J. Med. 36: 1, 1967. Google Scholar6. ADAMSJOWSEY PJ: Bone and mineral metabolism in hyperthyroidism: an experimental study. Endocrinology 81: 735, 1967. CrossrefMedlineGoogle Scholar7. KLEEMANBERNSTEINROCKNEYDOWLINGMAXWELL CRDRJTMH: Studies on the renal clearance of diffusible calcium and the role of the parathyroid glands in its regulation. Yale J. Biol. Med. 34: 1, 1961. MedlineGoogle Scholar8. HARRISONHARDENALEXANDER MTRMWD: Some effects of parathyroid hormone in thyrotoxicosis. J. Clin. Endocr. 24: 214, 1964. CrossrefGoogle Scholar9. MORIITALMAGE HRV: Effect of iodide-deficiency on thyrocalcitonin secretion. Proc. Soc. Exp. Biol. Med. 122: 382, 1966. CrossrefMedlineGoogle Scholar10. DUNCANCARE TAD: The effect of antithyroid drugs on thyrocalcitonin secretion. Brit. J. Surg. 54: 196, 1967. CrossrefMedlineGoogle Scholar11. ALIAPOULIOSVOELKELMUNSON MAEFPL: Assay of human thyroid glands for thyrocalcitonin activity. J. Clin. Endocr. 26: 897, 1966. CrossrefGoogle Scholar12. AUBALBRIGHTBAUERROSSMEISL JCFWE: Studies of calcium and phosphorus metabolism. VI. In hypoparathyroidism and chronic steatorrhea with tetany with special consideration of the therapeutic effect of thyroid. J. Clin. Invest. 11: 211, 1932. CrossrefMedlineGoogle Scholar13. BREUERMCPHERSON RIHT: Hypercalcemia in concurrent hyperthyroidism and hyperparathyroidism. Arch. Intern. Med. (Chicago) 118: 310, 1966. CrossrefMedlineGoogle Scholar14. EPSTEINFREEDMANLEVITIN FHLRH: Hypercalcemia, nephrocalcinosis and reversible renal insufficiency associated with hyperthyroidism. New Eng. J. Med. 258: 782, 1958. CrossrefMedlineGoogle Scholar15. BAXTERBONDY JDPK: Hypercalcemia of thyrotoxicosis. Ann. Intern. Med. 65: 429, 1966. LinkGoogle Scholar16. HUTHMAYOCKKERR EJRLRM: Hyperthyroidism associated with renal tubular acidosis. Discussion of possible relationship. Amer. J. Med. 26: 818, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Yale University School of Medicine New Haven, Conn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTitle-Holding CompaniesPrimary HyperparathyroidismHyperparathyroidism associated with hyperthyroidismHYPERCALCAEMIA AND METASTATIC BONE DISEASE: IS THERE A CAUSAL LINK?LiteraturverzeichnisParathyroid-independent change in renal handling of phosphate in hyperthyroid ratsSubacute Thyroiditis with Increased Serum Alkaline PhosphataseJOSEPH R. DALOVISIO, M.D., LAWRENCE BLONDE, M.D., LAURENCE M. CORTEZ, M.D., GEORGE A. PANKEY, M.D., F.A.C.P.Parathyroid Physiology and Primary HyperparathyroidismApology for "Hypercalcinuria"OLIVER M. WRONG, M.D., F.R.C.P., TERRY G. FEEST, M.B.The Thyroid GlandHypoparathyroidism After 131I TherapyMILFORD FULOP, M.D.HYDROXYPROLINE EXCRETION IN THE URINE AND CALCIUM METABOLISM DURING LONG-TERM TREATMENT OF THYROTOXICOSIS WITH PROPYLTHIOURACILNutrition and Endocrine Disease 1 February 1968Volume 68, Issue 2Page: 490-491KeywordsBoneBone and mineral metabolismCalciumHypercalcemiaHyperthyroidismPhosphorusSkeletonThyroid hormonesUrineWeight loss Issue Published: 1 February 1968 PDF DownloadLoading ...