tbuckley/cabot-search huggingface dataset:
Identification of Target Antigens of Antifibroblast Antibodies in Pulmonary Arterial Hypertension
Authors: Benjamin Terrier, Mathieu C. Tamby, Luc Camoin, Philippe Guilpain, Cédric Broussard, Guillaume Bussone, Azzedine Yaïci, Françoise Hotellier, Gérald Simonneau, Loïc Guillevin, Marc Humbert, Luc Mouthon
Journal: American Journal of Respiratory and Critical Care Medicine (2008)

Rationale: Pulmonary arterial hypertension (PAH) may be classified as idiopathic (IPAH) or familial (FPAH) or associated with various conditions and exposures such as dexfenfluramine intake (Dex-PAH) or systemic sclerosis (SSc-PAH). Because fibroblast dysfunction has been identified in SSc and IPAH and antifibroblast antibodies (AFAs) with a pathogenic role have been detected in the serum of SSc patients, we used a proteomic approach combining two-dimensional electrophoresis and immunoblotting to identify the target antigens of AFAs in such patients.Objectives: To identify target antigens of antifibroblast antibodies in pulmonary arterial hypertension.Methods: Sera from 24 patients with IPAH, 6 with FPAH, 6 with Dex-PAH, and 12 with SSc-PAH were collected. We pooled sera from sets of three patients with PAH classification and SSc-PAH based on autoantibody profile. Sera from 14 healthy blood donors were also pooled and used as a control.Measurements and Main Results: Serum IgG antibodies in the pools of patients with IPAH (n = 8), FPAH (n = 2), Dex-PAH (n = 2), and SSc-PAH (n = 4) recognized 103 ± 31, 63 ± 20, 78 ± 11, and 81 ± 12 protein spots, respectively, whereas serum IgG antibodies from healthy control subjects recognized 43 ± 22 protein spots. Twenty-one protein spots were specifically recognized by the serum IgG antibodies from patients with PAH. We identified 16 of the protein spots as vimentin, calumenin, tropomyosin 1, heat shock proteins 27 and 70, glucose-6-phosphate-dehydrogenase, phosphatidylinositol 3-kinase, DAP kinase, and others. These proteins are involved in regulation of cytoskeletal function, cell contraction, oxidative stress, cell energy metabolism, and other key cellular pathways.Conclusions: AFAs detected in patients with PAH recognize cellular targets playing key roles in cell biology and maintenance of homeostasis.
Comprehensive Management of High Risk Cardiovascular Patients
Authors: Tsung O. Cheng
Journal: Annals of Internal Medicine (2008)

Medical Writings: Book Notes18 March 2008Comprehensive Management of High Risk Cardiovascular PatientsTsung O. Cheng, MDTsung O. Cheng, MDFrom The George Washington University, Washington, D.C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-6-200803180-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Gotto AM Jr, Toth PP, eds. 770 pages. New York: Informa; 2007. $99.95. ISBN 1420066773. Order at www.informahealthcare.com.Field of medicine: Primary care, internal medicine, and cardiology.Format: Hardcover book.Audience: Internists, cardiologists, and cardiac surgeons.Purpose: Part of the Fundamental and Clinical Cardiology Series to “help fill a large gap in the management of patients who have, or are at risk of developing, cardiovascular disease.”Content: This multiauthored book deals with everyday issues of caring for patients with specific cardiovascular and cardiometabolic disorders. The 21 chapters cover many topics, including risk factors for cardiovascular disease, obesity and lifestyle modification, ... Author, Article, and Disclosure InformationAffiliations: From The George Washington University, Washington, D.C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 18 March 2008Volume 148, Issue 6Page: 488KeywordsCardiology and cardiovascular diseasesCardiovascular diseasesCardiovascular therapyObesityPericardial diseasesRenal diseasesSoftware toolsStable coronary artery diseaseSurgeonsValvular diseases ePublished: 18 March 2008 Issue Published: 18 March 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PNEUMATIC ILLUMINATED INFANTILE SIGMOIDOSCOPEA NEW RECTAL INSTRUMENT
Authors: W. H. AXTELL
Journal: JAMA (1910)

This instrument was designed primarily for the examination and treatment of rectal diseases in children. Reflected light gave very unsatisfactory results because of the resistance and struggle of the little patients. The light could not be placed and fixed at the point to be examined as it can with this instrument. These drawings and designs were made by me and sent to the Electro-Surgical Instrument Company of Rochester, N. Y., who produced a most satisfactory instrument. It is simply a modification of Dr. James P. Tuttle's 6-inch illuminated pneumatic proctoscope. I claim originality only for the instrument being made for the examination and treatment of children. The modifications are as follows: 1. The instrument is very much reduced in caliber. 2. The auxiliary chamber is placed wholly within the tube in order to make the instrument as small as possible and yet give ample room for making application through it.
1157-48 Reduced shear stress and large shear stress gradient cause coronary aneurysm and thrombus formation in children with Kawasaki disease
Authors: Ei Ikegami, Ryuji Fukazawa, Mituhiro Kamisago, Miharu Hajikano, Miki Watanabe, Yohko Uchikoba, Yasuhiro Katube, Shunichi Ogawa
Journal: Journal of the American College of Cardiology (2004)
NEW STYLE DRAIN-PAN FOR OPERATING-TABLE
Authors: W. M. Hayes
Journal: JAMA (1913)

The old style drain-pan being oval or nearly circular, there has always been trouble in keeping it sufficiently near the operating-table. When placed against the lower supporting rods of the table, the pan would rotate from place to place along the side of the table, allowing the refuse which should drain from the Kelly pad into pan, to go on the floor, much to the annoyance of the operator and his assistants. This pan (Fig. 1) is two-thirds round or oval while one-third has a flat back surface which permits the pan to be placed squarely against the lower rods of the table (Fig. 2), thus preventing it from moving from its original place. 1525 Calliope Street.
H63D HFE gene mutation is a positive predictive factor to response to antiviral therapy in chronic hepatitis C
Authors: P. Lebray, H. Zylberberg, S. Hue, S. Martin, Y. Chrétien, B. Poulet, B. Nalpas, S. Pol, S. Caillat-Zuckman, C. Bréchot
Journal: Journal of Hepatology (2000)
THE NATURE OF STORAGE IRON IN IDIOPATHIC HEMOCHROMATOSIS AND IN HEMOSIDEROSIS
Authors: Goetz W. Richter
Journal: The Journal of Experimental Medicine (1960)

Using three different methods of cells fractionation, hemosiderin granules were isolated from tissues (liver and/or spleen) of three patients. The samples were obtained from a case of idiopathic hemochromatosis, a case of thalassemia major with secondary (transfusional?) hemosiderosis, and a case of transfusional hemosiderosis associated with an unclassified anemia. Iron, nitrogen, and protein content of the hemosiderin granules varied over a wide range. Electron microscopy of sectioned granules revealed aggregates of dense particles of different shapes, with diameters ranging from 10 A to about 75 A. In some of the granules dense particles corresponding to the iron hydroxide micelles of ferritin molecules were abundant. But many of the granules contained very few of these molecules. The presence of ferritin and apoferritin in the samples of hemosiderin granules was demonstrated by means of precipitin tests in agar-gel, using rabbit antiferritin sera with known antibody nitrogen concentrations. At least three antigenic components were detected in highly purified crystalline ferritin prepared from tissues of the three patients; the hemosiderin granules contained the same antigens, but probably in much smaller quantities. Both ferritin and apoferritin molecules were extracted from hemosiderin granules, and were demonstrated in the electron microscope after suitable preparation. The solubility curve of human ferritin in solutions of (NH(4))(2)SO(4) was investigated. The results indicate that substantial quantities of ferritin or apoferritin can be lost in saline, aqueous media during isolation of hemosiderin granules from cells. It was shown by means of electron microdiffraction on selected hemosiderin granules that the dense particles represent forms of partly hydrated alpha-Fe(2)O(3). The conditions necessary for electron microdiffraction in an electron microscope precluded an exact determination of the state of hydration of the alpha-Fe(2)O(3) or of its structural relation to (FeOOH) micelles of pure ferritin in its undenatured state. The findings were considered in the light of evidence on the structure and disposition of hemosiderin in situ in cells, and on the structure of ferritin. Differences between endogenous hemosiderin and hemosiderin derived from injections of colloidal iron compounds were pointed out. The evidence indicates that in hemochromatosis and in secondary hemosiderosis much of the inorganic storage iron in liver and spleen is derived from degraded ferritin. The findings suggest that an abnormal cellular metabolic pathway of ferritin is implicated in the pathogenesis of hemochromatosis and transfusional hemosiderosis.
Human CD34 <sup>+</sup> Cells in Experimental Myocardial Infarction
Authors: Jingxiong Wang, Sui Zhang, Brian Rabinovich, Luc Bidaut, Suren Soghomonyan, Mian M. Alauddin, James A. Bankson, Elizabeth Shpall, James T. Willerson, Juri G. Gelovani, Edward T.H. Yeh
Journal: Circulation Research (2010)

Rationale : Human CD34 + cells have been used in clinical trials for treatment of myocardial infarction (MI). However, it is unknown how long the CD34 + cells persist in hearts, whether the improvement in cardiac function is sustained, or what are the underlying mechanisms. Objective : We sought to track the fate of injected human CD34 + cells in the hearts of severe combined immune deficiency (SCID) mice after experimental MI and to determine the mechanisms of action. Methods and Results : We used multimodality molecular imaging to track the fate of injected human CD34 + cells in the hearts of SCID mice after experimental MI, and used selective antibody blocking to determine the mechanisms of action. Bioluminescence imaging showed that injected CD34 + cells survived in the hearts for longer than 12 months. The PET signal from the injected cells was detected in the wall of the left ventricle. Cardiac MRI showed that left ventricular ejection fraction was significantly improved in the treated mice compared to the control mice for up to 52 weeks ( P &lt;0.05). Furthermore, treatment with anti-α4β1 showed that generation of human-derived cardiomyocytes was inhibited, whereas anti–vascular endothelial growth factor (VEGF) treatment blocked the production of human-derived endothelial cells. However, the improvement in cardiac function was abolished only in the anti-VEGF, but not anti-α4β1, treated group. Conclusions : Angiogenesis and/or paracrine effect, but not myogenesis, is responsible for functional improvement following CD34 + cells therapy.
SIDEROFIBROSIS OF THE SPLEEN IN SICKLE CELL ANEMIA
Authors: L. W. DIGGS
Journal: JAMA (1935)

The pathologic condition of the spleen in sickle cell anemia is characterized by a series of progressive changes from congestive enlargement to fibrotic atrophy. The gross and microscopic appearances of spleens examined at different intervals in this process are varied and apparently dissimilar. The descriptions of the thirty-three spleens available in the literature<sup>1</sup>are mostly in the form of single case reports by different authors, and with few exceptions they are brief and lacking in essential details. It is difficult to obtain from these descriptions a clear concept of the sequence of events or a picture of the process as a whole. It is my purpose in this paper to describe the lesions of the spleen in sickle cell anemia, to trace the develop
Oral pyoderma gangrenosum
Authors: A. Hernandez-Martin, D. Arias-Palomo, G. Hermida, M.C. Gutierrez-Ortega, M. Ramirez-Herrera, M. Rodriguez-Vegas, A. Velasco
Journal: British Journal of Dermatology (2003)

Journal Article Oral pyoderma gangrenosum Get access A. Hernández‐Martín, A. Hernández‐Martín Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar D. Arias‐Palomo, D. Arias‐Palomo Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar G. Hermida, G. Hermida Haematology Search for other works by this author on: Oxford Academic Google Scholar M.C. Gutiérrez‐Ortega, M.C. Gutiérrez‐Ortega Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar M. Ramírez‐Herrera, M. Ramírez‐Herrera Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar M. Rodríguez‐Vegas, M. Rodríguez‐Vegas Plastic Surgery and Search for other works by this author on: Oxford Academic Google Scholar A. Velasco A. Velasco Pathology, Hospital General Yagüe, Avda. del Cid 96, 09005 Burgos, Spain E‐mail: ahernandez@hgy.es Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 3, 1 September 2003, Pages 663–664, https://doi.org/10.1046/j.1365-2133.2003.05503.x Published: 01 September 2003
The NFL's Drug Testing Policy
Authors: Roberta Baskin
Journal: JAMA (1991)

<h3>To the Editor. —</h3> I read with great interest Dennis L. Breo's At Large tribute to Dr Forest Tennant, the former drug adviser to the National Football League (NFL).<sup>1</sup>Breo's column came in response to a series of investigative reports I presented over the past year on WJLA-TV (ABC) in Washington, DC. The investigation focused on the league's drug-testing policy, which we found lacked accuracy and confidentiality and was only selectively enforced. Dr Tennant announced his resignation 1 month after our initial series of reports. As I began to read Breo's comments, I soon realized that he had probably not seen any of those reports. There were no specific criticisms. Indeed, Breo's first insinuation that some of Dr Tennant's former employees, who had supplied information and documents to me, "may have been paid" is flat wrong. He also states that my reports were "based, in large degree, upon transcripts
Detecting diabetic retinopathy: Author's reply
Authors: R. Taylor
Journal: BMJ (1991)

Thirdly, it is probably most important to detect patients with pre-proliferative retinopathy.No mention of this group was made except under the criteria for referral.Fourthly, it is of concern that so many cases with new vessels were detected at all, but no attempt was made to differentiate "new vessels disc" from "new vessels elsewhere."There is concern over the accuracy of Polaroid photographs in detecting new vessels elsewhere.Fifthly, the test of diagnostic accuracy for each grade of staff is the photography itself.The implication is that photographs are more accurate than clinicians.That the authors consider "the relatively poor performance of all grades" of staff "interesting" is worrying.Much was made of the difficulty of examining the macula, but this is a matter of training.Characteristically the changes of diabetic retinopathy occur temporal to the macula so the fact that clinicians do not screen this area should cause concern.It is important to note that consultants performed better than juniors; this reflects experience, but all screening staff should be familiar with new vessels.Lastly, costs were compared with standard sight test charges, but there was no discussion of improvements as a result of training or changes in practices, particularly the use of dedicated clinical assistants or nurses to examine vision and funduscopy using simple criteria for referral.
Immunoregulatory T Cell Function in Multiple Myeloma
Authors: H. Ozer, T. Han, E. S. Henderson, A. Nussbaum, D. Sheedy
Journal: Journal of Clinical Investigation (1981)

Multiple myeloma is a malignancy characterized by uncontrolled monoclonal B cell differentiation and immunoglobulin production. In most instances, there is concomitant reduction in polyclonal differentiation and immunoglobulin synthesis both in vivo and in vitro. In in vitro pokeweed mitogen-induced B cell differentiation assays, proliferation and polyclonal immunoglobulin secretion optimally requires T cell help and can be inhibited both by monocytes and suppressor T cells. Helper function and monocyte-mediated suppression are relatively radio-resistant whereas T suppressor function is sensitive to 2,000 rad x-irradiation. We have examined myeloma T cell subset function in this assay using recombinations of isolated patient and normal B cells, T cells, and T cell subsets. Monocytes were removed by a carbonyl iron ingestion technique, normal and myeloma T cells were fractionated on the basis of Fc receptors for immunoglobulin (Ig) G (Tgamma) or IgM (Tmu or T non-gamma), and proliferation and IgG secretion after co-culture determined by [(3)H]thymidine incorporation and radio-immunoassay, respectively. Myeloma B cells demonstrate quantitatively and qualitatively normal blastogenic responses and are appropriately regulated by either autologous or allogeneic T helper and suppressor subsets. Despite normal proliferation, however, myeloma B cells remain deficient in subsequent differentiation and immunoglobulin secretion even when co-cultured in the absence of monocytes or suppressor T cells and the presence of normal helper cells. Myeloma T cell populations, in contrast, are entirely normal in helper capacity over a range of T:B ratios but are markedly deficient in radiosensitive and concanavalin A-induced suppressor activity. T suppressor cell dysfunction in multiple myeloma is apparently due to a deficit in the T non-gamma suppressor subset, whereas Tgamma cells, although proportionately reduced, are functionally normal. This unique T suppressor deficit reflects the heterogeneity of suppressor mechanisms in this disease and may represent a compensatory response to the monoclonal proliferation or the involvement of regulatory T cells in the pathogenesis of the malignancy.
Red Cross calls for urgent medical help in face of growing civilian casualties from Pakistan conflict
Authors: J. Zarocostas
Journal: BMJ (2009)

The International Committee of the Red Cross has called for urgent medical help to reach and treat growing numbers of sick and wounded people caught in the conflict between Pakistani forces and Taliban militants in South Waziristan.

The Red Cross’s head of operations for South Asia, Jacques de Maio, said that there are rising numbers of people reaching surgical facilities, first aid posts, and health units manned and run with support from the committee by the Pakistani Red Crescent in different areas.

“What we see now is a sharp and extremely worrying …
Frances Kelsey Honored for FDA Legacy
Authors: Bridget M. Kuehn
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P1-08-24: Clinical and Pathologic Characteristics of Diabetic Breast Cancer Patients in a Tertiary Care Safety Net Hospital.
Authors: MM Loch, A Eapen, AA Ross, C Rosenberg, RA Blanchard
Journal: Cancer Research (2011)

Abstract Background: Recent studies have indicated an increased risk of breast cancer in women with diabetes, and an increase in disease specific mortality in patients with diabetes and breast cancer. Clinical and pathologic features of diabetic women with breast cancer have not been described. We examine tumor characteristics in diabetic women in our ethnically diverse tertiary care hospital that may help explain the increased mortality seen in diabetic women diagnosed with breast cancer. Methods: We expanded a pre-existing database to include all women diagnosed with breast cancer from 1998–2011. From the electronic medical record we documented age, body mass index (BMI), place of birth, self-identified race/ethnicity, date of diagnosis, T, N, M stage, grade, ER, PR, HER2 expression, presence of diabetes (DM) or thyroid disease at diagnosis, recurrence and treatment data including neoadjuvant, surgical, adjuvant and radiation therapy and adequacy of treatment. We determined associations using contingency tables and multivariate logistic regression. Results: 480 cases were identified. Patients were racially diverse: 35% white [W], 41% black [B], 14% Hispanic and 10% other. 23% had DM, 47% were obese (body mass index [BMI] &amp;gt;30). Age in DM vs. non-DM were 63.327 vs. 57.729 (p= &amp;lt; 0.0001) and BMI in DM vs. non-DM were 32.749 vs. 29.433 (p&amp;lt;0.001). When exploring odds ratios (OR) of different tumor subtypes, none were statistically significant when controlling for age and BMI. The OR calculated were as follows: Triple negative 1.00 (confidence interval [CI]: 0.6−1.666, p = 0.9996), ER+ 1.063 (CI: 0.68−1.662, p=0.7877), PR+ 1.005 (CI: 0.67−1.506, p=0.9811), HER2+ 1.011 (CI: 0.578−1.768, p= 0.8535), recurrence: 1.090 (CI: 0.634−1.873, p= 0.7558). There were no significant interactions with DM and T, N stage when controlling for age and BMI. T stage: p=0.6962, N stage: p=0.7349 and recurrence p=0.5469 on recurrence controlling for age, BMI and grade: p=0.5462. There was no significant association between grade in DM vs. no DM with rates of grade in DM as follows: grade 1: 10.81%, grade 2: 49.55%, grade 3: 39.64% and in non-DM grade 1: 13.55%, grade 2: 45.8% and grade 3: 40.65%. Mean score difference p=0.7588. Conclusions: We did not find significant differences in our DM women compared with non-DM women when evaluating tumor subtype, T stage, N stage, grade or recurrence. In our patient population these factors do not play a role in the increased cause specific mortality in DM patients with breast cancer. Other factors must play a role in this and should be explored further. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P1-08-24.