tbuckley/cabot-search huggingface dataset:
Abstract 2635: CBP501-calmodulin binding contributes to sensitizing tumor cells to CDDP and BLM
Authors: NAOKI MINE, Sayaka Yamamoto, Naoya Saito, Donald W. Kufe, Daniel D. VonHoff, Takumi Kawabe
Journal: Cancer Research (2011)

Abstract CBP501 is an anti-cancer drug candidate currently under the Phase II clinical trials on non-small cell lung carcinoma (NSCLC) and malignant pleural mesotherioma (MPM). CBP501 was originally described as a unique G2 checkpoint-directed agent that binds to 14-3-3, inhibiting the actions of Chk1, Chk2, MAPKAP-K2, or C-Tak1. However, unlike a G2 checkpoint inhibitor, CBP501 clearly enhances the G2/M accumulation induced by cisplatin (CDDP) or bleomycin (BLM) at low dose and short exposure to tumor cells. It does not affect the accumulation at G2/M by radiation, doxorubicin or 5-FU treatment in the same condition. Our recent findings point to an additional mechanis of action (MOA) for CBP501. The enhanced G2/M accumulation by CDDP results from increased intracellular platinum concentration, which leads to increased binding of platinum to DNA. The observed CBP501-induced platinum accumulation is negated in the presence of excess Ca2+. Some calmodulin (CaM) inhibitors behave similarly to CBP501. But the therapeutic window of CBP501 was broader than CaM inhibitors. Furthermore, analysis by surface plasmon resonance (SPR) reveals a direct, high-affinity molecular interaction between CBP501 and CaM (Kd=4.62×10−8M) that is reversed by Ca2+, whereas the Kd for the complex between CBP501 and 14-3-3 is some 10-fold weaker and is Ca2+-independent. We conclude that calmodulin inhibition plays important role in the activity of CBP501 in sensitizing cancer cells to CDDP or BLM. This report presents the prospects for the development of a new class of anti-cancer drugs through the addition of unique calmodulin inhibition. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2635. doi:10.1158/1538-7445.AM2011-2635
The Ocular Effects of Intracarotid Bromodeoxyuridine and Radiation Theraphy in the Treatment of Malignant Glioma
Authors: James F. Vander, Marilyn C. Kincaid, Thomas J. Hegarty, Michaelyn Page, Damon Averill, Larry Junck, Harry S. Greenberg
Journal: Ophthalmology (1990)
Nitroglycerin Tablets Loss of Potency
Authors: Frank J. Briganti
Journal: JAMA (1971)

<h3>To the Editor.—</h3> In reference to the communication on nitroglycerin (<b>216</b>:878, 1971), I believe the study was incomplete because it did not include the polyethylene container used to package nitroglycerin. The polyethylene container did pass Food and Drug Administration tests for packaging, and the product retains its potency for up to five years in an unopened container. The manufacturer has instructed the pharmacist on the container label to "dispense in glass or polyethylene only." Thus it would be correct to dispense nitroglycerin tablets in glass or polyethylene containers.
Atriofascicular connection or a nodoventricular Mahaim fiber? Electrophysiologic elucidation of the pathway and associated reentrant circuit.
Authors: P Tchou, M H Lehmann, M Jazayeri, M Akhtar
Journal: Circulation (1988)

Accessory pathways showing decremental properties and inserting into the right ventricle have been frequently described as "nodoventricular" or Mahaim pathways. However, conclusive evidence for a nodal origination of such pathways is lacking. The patient in this study had characteristics typical of such a pathway. Antegradely, the pathway showed decremental, nodelike conduction properties. With the aid of right bundle branch recordings, the pathway was demonstrated to insert directly into the right bundle branch. Atrioventricular reciprocating tachycardia could be readily initiated by atrial or ventricular pacing. The QRS morphology was normal during sinus rhythm and demonstrated a left bundle branch block pattern with normal axis during tachycardia. The reentrant circuit involved antegrade conduction over the accessory pathway and retrograde conduction via the bundle branches, His bundle, and the atrioventricular node. More significantly, late atrial stimuli delivered during tachycardia could preexcite the ventricle via the accessory pathway despite their inability to enter the atrioventricular node. Thus, the upper "turn around" of the reentrant circuit involved atrial tissue and the accessory pathway originated directly from the right atrium independent of the atrioventricular node. In view of these new findings and other recent observations during surgical resection of similar pathways, a reassessment of previous descriptions of "nodoventricular" fibers may be necessary. Many of these pathways may actually represent atriofascicular or atrioventricular connections with decremental properties.
Combination Therapies against Chronic Myeloid Leukemia: Short-term versus Long-term Strategies
Authors: Natalia L. Komarova, Dominik Wodarz
Journal: Cancer Research (2009)

During therapy for chronic myeloid leukemia (CML), decline of the number of BCR-ABL transcripts has been shown to follow a biphasic pattern, with a fast phase followed by a slower phase. Hence, sustained remission requires a long phase of therapy. Data indicate that a combination of different available targeted drugs might prevent treatment failure due to drug resistance, especially at advanced stages of the disease. However, for long-term multiple-drug treatments, complications can arise from side effects. We investigate whether and how the number of drugs could be reduced during long-term therapy. Using computational models, we show that one or more drugs can be removed once the number of tumor cells is reduced significantly, without compromising the chances of sustained tumor suppression. Which drug to remove first depends on the number of mutations in the BCR-ABL gene that confer resistance to the drugs, as well as on how effectively the drugs inhibit Bcr-Abl protein tyrosine kinase activity and inhibit tumor growth. We further show that the number of CML cells at which the number of drugs can be reduced does not correlate with the two phases of decline of the BCR-ABL transcript numbers. Neither does it depend much on kinetic parameters of CML growth, except for the mutation rates at which resistance is generated. This is a significant finding because even without any information on most parameters, and using only the data on the number of cancer cells and the rate at which resistant mutants are generated, it is possible to predict at which stage of treatment the number of drugs can be reduced.
CD141+ dendritic cells produce prominent amounts of IFN-α after dsRNA recognition and can be targeted via DEC-205 in humanized mice
Authors: Sonja Meixlsperger, Carol S. Leung, Patrick C. Rämer, Maggi Pack, Liliana D. Vanoaica, Gaëlle Breton, Steve Pascolo, Andres M. Salazar, Andrzej Dzionek, Jürgen Schmitz, Ralph M. Steinman, Christian Münz
Journal: Blood (2013)
Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia
Authors: Reisa A. Sperling, Peter S. LaViolette, Kelly O'Keefe, Jacqueline O'Brien, Dorene M. Rentz, Maija Pihlajamaki, Gad Marshall, Bradley T. Hyman, Dennis J. Selkoe, Trey Hedden, Randy L. Buckner, J. Alex Becker, Keith A. Johnson
Journal: Neuron (2009)
Thyrocardiac Disorder Without Overt Hyperthyroidism.
Authors: Cecil Symons
Journal: Annals of Internal Medicine (1968)

s1 May 1968Thyrocardiac Disorder Without Overt Hyperthyroidism.Cecil Symons, M.D.Cecil Symons, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1145_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwo groups of patients are described and compared, each of whom presented with symptoms and signs referable to the cardiovascular system, generally without thyroid gland enlargement, and who were found to have abnormal thyroid function studies.In the first group (I), thyroid 131I uptake, labeled triiodothyronine resin uptake, and serum protein-bound iodine estimations were in the hyperthyroid range and were therefore examples of masked hyperthyroidism, but in the second group (II) only the protein-bound iodine level was raised.The clinical characteristics and hyperthyroid "index scores" were compared and the response to treatment described.The possible causes of the raised protein-bound... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: London, PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByUNUSUAL PRESENTATION OF THYROCARDIAC DISEASE 1 May 1968Volume 68, Issue 5Page: 1145-1145KeywordsHyperthyroidismProteinsSerum proteinsSigns and symptomsThyroidTriiodothyronine Issue Published: 1 May 1968 PDF DownloadLoading ...
Albert Norman Ashworth
Authors: A. Ashworth
Journal: BMJ (2002)

Former consultant ophthalmologist Queen Alexandra Hospital, Portsmouth, and St Richard's Hospital, Chichester (b 1918; q Manchester 1942; MD, FRCOpth), died from pneumonia and myeloma on 13 June 2002.

He served with the Royal Air Force during the second world war and was squadron leader consultant at Yatesbury in Wiltshire. He leaves a wife, Dorothy; and two sons.
Report on the Meeting of the International Committee of Dermatology
Authors: Nils Thyresson
Journal: British Journal of Dermatology (1981)

Journal Article Report on the Meeting of the International Committee of Dermatology Get access Nils Thyresson Nils Thyresson Secretary‐General, ICD Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 104, Issue 2, 1 February 1981, Pages 227–228, https://doi.org/10.1111/j.1365-2133.1981.tb00052.x Published: 01 February 1981
Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease
Authors: Leon A. Adams, Scott W. White, Julie A. Marsh, Stephen J. Lye, Kristin L. Connor, Richard Maganga, Oyekoya T. Ayonrinde, John K. Olynyk, Trevor A. Mori, Lawrence J. Beilin, Lyle J. Palmer, Jeffrey M. Hamdorf, Craig E. Pennell
Journal: Hepatology (2012)

Genetic factors account for a significant proportion of the phenotypic variance of nonalcoholic fatty liver disease (NAFLD); however, very few predisposing genes have been identified. We aimed to (1) identify novel genetic associations with NAFLD by performing a genome-wide association study (GWAS), and (2) examine the biological expression of the strongest genetic associations in a separate cohort. We performed GWAS of a population-based cohort (Raine Study) of 928 adolescents assessed for NAFLD by ultrasound at age 17. Expression of genes with single nucleotide polymorphisms (SNPs) that were associated with NAFLD at a significance level of P < 10(-5) was examined in adults with NAFLD and controls by quantifying hepatic messenger RNA (mRNA) expression and serum levels of protein. After adjustment for sex and degree of adiposity, SNPs in two genes expressed in liver were associated with NAFLD adolescents: group-specific component (GC) (odds ratio [OR], 2.54; P = 1.20 × 10(-6)) and lymphocyte cytosolic protein-1 (LCP1) (OR, 3.29; P = 2.96 × 10(-6)). SNPs in two genes expressed in neurons were also associated with NAFLD: lipid phosphate phosphatase-related protein type 4 (LPPR4) (OR, 2.30; P = 4.82 × 10(-6)) and solute carrier family 38 member 8 (SLC38A8) (OR, 3.14; P = 1.86 × 10(-6) ). Hepatic GC mRNA was significantly reduced (by 83%) and LCP1 mRNA was increased (by 300%) in liver biopsy samples from patients with NAFLD compared to controls (P < 0.05). Mean serum levels of GC protein were significantly lower in patients with NAFLD than controls (250 ± 90 versus 298 ± 90, respectively; P = 0.004); GC protein levels decreased with increasing severity of hepatic steatosis (P < 0.01).The association between GC and LCP1 SNPs and NAFLD as well as altered biological expression implicate these genes in the pathogenesis of NAFLD.
Some Medical Aspects of Mathematical Biology
Authors: Anthony F. Bartholomay
Journal: JAMA (1964)

The senior in the relatively new discipline of mathematical biology has made a highly laudable attempt to communicate to the medical profession the spirit, general<i>modus operandi</i>, and a few medically meaningful results of that discipline. In his own words: "the emphasis... is definitely on the word<i>some</i>. The book is not intended to be a comprehensive treatise on all possible medical aspects of mathematical biology." Rather it discusses selected topics of medical interest—respiratory, cardiovascular, pharmacological, endocrine, and neurophysiological and psychological. In the first part Dr. Rashevsky shows how, starting with a simple geometric model of the respiratory system, we may derive mathematical formulas to predict the concentration of inspired particles in various parts of the system. In the cardiovascular discussion he brings together two distinct theories: (1) O. Frank's elastic reservoir model of the circulatory system and (2) the theory of propagation of pulse waves, from which he derives
THE EFFECT OF PNEUMOCOCCUS AUTOLYSATES UPON PNEUMOCOCCUS DERMAL INFECTION IN THE RABBIT
Authors: Kenneth Goodner
Journal: The Journal of Experimental Medicine (1933)

In pneumococcus dermal infections in rabbits, the addition of pneumococcus autolysate to an infective inoculum favors the invasiveness of the particular strain employed, but does not alter the kind of virulence possessed by that strain. Autolysates exhibiting this enhancing property also induce purpura in mice and inhibit the coagulation of rabbit blood. The relation of these properties to the infectivity of Pneumococcus and the possible role of bacterial autolysis in natural infection are discussed.
Candidates for coronaries.
Authors: L Smith
Journal: BMJ (1972)

Gastrin and Gastrointestinal Disease SIR,-We were interested in your leading article on this topic (9 September, p. 604), but we think your statement that gastrin may affect intestinal motility needs qualification.In doses producing near-maximal gastric- acid secretion both gastrin and pentagastrin were found to stimulate motility in the gastric antrum, but no effect on colonic motor activity could be detected.1 2 As you point out, serum gastrin levels are high in patients with pernicious anaemia but are likely to be low after total gastrectomy.Colonic pressure activity, however, especially after a protein-containing meal, is greater after total gastrectomy than in pernicious anaemia.3It would therefore seem unlikely that gastrin is involved in the colonic motor response to meals.3-Weare, etc.,
The Family Physician as an Educator
Authors: Charles R. Alvey
Journal: JAMA (1961)

THERE IS a shortage of general practitioners— family doctors—generalists—call them what you may. This is true in our urban as well as our rural areas. It is true throughout this great country of ours. I do not mean that there is a shortage of physicians, but there<i>is</i>a need for physicians who are interested in the total and continuing care of the patient. This is shown by many statistics. If you desire to check for yourself, look in the classified advertising section ofThe Journal, where you will note an increasing number of insertions asking for general practitioners. The<i>New England Journal of Medicine</i>reports that 95 per cent of all requests from Massachusetts communities are for general practitioners, but 75 per cent of the physicians seeking locations are of the specialty groups. It is our job to attempt to correct this situation. The subject chosen for discussion at
Explorations in the Economics of Aging
Authors: Karunesh Tuli
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Smooth muscle myosin heavy chain exclusively marks the smooth muscle lineage during mouse embryogenesis.
Authors: J M Miano, P Cserjesi, K L Ligon, M Periasamy, E N Olson
Journal: Circulation Research (1994)

We cloned a portion of the mouse smooth muscle myosin heavy chain (SM-MHC) cDNA and analyzed its mRNA expression in adult tissues, several cell lines, and developing mouse embryos to determine the suitability of the SM-MHC promoter as a tool for identifying smooth muscle-specific transcription factors and to define the spatial and temporal pattern of smooth muscle differentiation during mouse development. RNase protection assays showed SM-MHC mRNA in adult aorta, intestine, lung, stomach, and uterus, with little or no signal in brain, heart, kidney, liver, skeletal muscle, spleen, and testes. From an analysis of 14 different cell lines, including endothelial cells, fibroblasts, and rhabdomyosarcomas, we failed to detect any SM-MHC mRNA; all of the cell lines induced to differentiate also showed no detectable SM-MHC. In situ hybridization of staged mouse embryos first revealed SM-MHC transcripts in the early developing aorta at 10.5 days post coitum (dpc). No hybridization signal was demonstrated beyond the aorta and its arches until 12.5 to 13.5 dpc, when SM-MHC mRNA appeared in smooth muscle cells (SMCs) of the developing gut and lungs as well as peripheral blood vessels. By 17.5 dpc, SM-MHC transcripts had accumulated in esophagus, bladder, and ureters. Except for blood vessels, no SM-MHC transcripts were ever observed in developing brain, heart, or skeletal muscle. These results indicate that smooth muscle myogenesis begins by 10.5 days of embryonic development in the mouse and establish SM-MHC as a highly specific marker for the SMC lineage. The SM-MHC promoter should therefore serve as a useful model for defining the mechanisms that govern SMC transcription during development and disease.
Birth ranks of spontaneous abortions in sibships of children affected by anencephaly or spina bifida.
Authors: W H James
Journal: BMJ (1978)

Data on the birth ranks of miscarriages within sibships in which a case of anencephaly or spina bifida (ASB) had occurred were analysed by the Haldane-Smith statistical test. This showed that miscarriages in ASB sibships tend to have a negative birth order effect--that is, they occur in earlier rather than later pregnancies within the sibship. The strongest source of bias in this analysis--the fact that mothers tend to forget early spontaneous abortions--worked against this finding, so the negative birth order effect is probably genuine. Because ASB itself shows a negative birth order effect and because spontaneous abortions in normal sibships do not show such an effect, the additional spontaneous abortions in ASB sibships are probably of fetuses affected by ASB.
Abstract 2141: Dietary feeding of Kava root extract inhibits prostate carcinogenesis in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model
Authors: Xuesen Li, Christopher A. Blair, Xiaolin Zi
Journal: Cancer Research (2014)

Abstract Kava kava has been traditionally used to prepare beverages and herbal medicines in the Pacific Islands. Men living in Fiji and drinking kava have low incidence of prostate cancer (PCa). However, the PCa incidence among Fijian men who had migrated to Australia, increased by 5.1-fold. To determine the chemopreventive efficacy of kava root extracts, TRAMP mice were fed with commercial kava root extract supplemented food. In the prevention protocol, TRAMP mice were fed with 3 or 6 g (0.3% or 0.6%) kava root extract /kg food starting at 6 weeks of age and ending at 12 weeks of age, resulting in decreased numbers of high-grade prostatic intraepithelial neoplasia and moderately differentiated adenocarcinomas in kava root extract fed mice compared to the mice fed with control food (p&amp;lt;0.01). In the intervention protocol, in which TRAMP mice were fed with 0.3% or 0.6% kava root extract food starting at 6 weeks of age and ending at 24 weeks of age, the average genitourinary (GU) weight of 0.6% kava root extract fed mice was significantly reduced when compared to control food fed mice (1.98±2.07 gram vs.3.63±4.28 gram, p&amp;lt;0.05, Mann-Whitney U and Kolmogorov-Smirnov test). The percentages of large tumors (GU weight &amp;gt; 0.9 gram) were also decreased from 86.4% in the control group to 52.2% and 43.5% in 0.3 and 0.6 % kava food groups, respectively. In addition, we showed that kawain, the main component of kava root extracts, inhibited LSD1 enzyme activity, enhanced H3K9 dimethylation and decreased the mRNA expression of androgen receptor target genes, including PSA and TMPRSS2, in LNCaP cells. Taken together, these results suggested that dietary consumption of kava products have the potential to reduce the risk of prostate cancer development. Citation Format: Xuesen Li, Christopher A. Blair, Xiaolin Zi. Dietary feeding of Kava root extract inhibits prostate carcinogenesis in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2141. doi:10.1158/1538-7445.AM2014-2141
SPECIFIC AND NONSPECIFIC REMEDIES IN THE TREATMENT OF ENCEPHALITIS
Authors: WALTER FREEMAN
Journal: JAMA (1927)

The treatment of epidemic encephalitis depends greatly on the stage of the disease, whether acute, latent or chronic. During the first stage, the infection and the symptoms are attacked. During the latent period, efforts should be made to increase the resistance of the individual, to eradicate possible foci of infection, and to exterminate whatever organisms have not already been overcome by the defensive forces of the body. In the chronic stage, the attempt is made to stop the progress of the disease and to palliate such distressing symptoms as paralysis agitans and insomnia.  Many antiseptics, such as acriflavine, methenamine and sulphur, have been recommended in combating the infection during the first stage. Among the medicinal substances, however, the salicylates stand foremost. They are used extensively and in large doses, given intravenously if the stomach rebels. Acetylsalicylic acid is perhaps best tolerated, and may be administered in 0.3 Gm. doses every
Rheumatoid disease and rib defects.
Authors: W M Park, J Ball, D Ward, A Bane
Journal: Annals of the Rheumatic Diseases (1971)

The presence of deformity of the ribs has been an infrequently reported finding in chronic rheumatoid arthritis.*Examination of the radiographs of patients attending our Rheumatoid Clinic suggests that this deformity may be more common than at present appreciated.The benign nature of this lesion is stressed and in this report the clinical and radiological findings in eleven patients are evaluated.