Serum Antibodies Against Mouse Mammary Tumor-Virus-Associated Antigen Detected Nine Months Before Appearance of a Breast Carcinoma
Authors: MAN-CHlU POON
Journal: Annals of Internal Medicine (1983)

Brief Reports1 June 1983Serum Antibodies Against Mouse Mammary Tumor-Virus-Associated Antigen Detected Nine Months Before Appearance of a Breast CarcinomaMAN-CHlU POON, M. D., MILAN TOMANA, Ph.D, WILLIAM NIEDERMEIER, Ph.D.MAN-CHlU POON, M. D., MILAN TOMANA, Ph.D, WILLIAM NIEDERMEIER, Ph.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-6-937 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEarlier investigations (1-4) showed an immunologic relation between human breast cancer and mouse mammary tumor virus (MMTV). The presence of antibodies in sera of patients with breast cancer reacting with antigens in the cytoplasm of mouse mammary tumor cells was shown by various methods including indirect immunofluorescence (5). This reactivity could be abolished by absorption of the sera with MMTV (5, 6) or intracytoplasmic type A particles (7). The specificity of the reactivity of human antibodies with MMTV-associated antigens has been questioned by some investigators (8). Our patient's serum, initially nonreactive with MMTV-associated antigens, became reactive 9 months before the...References1. CHARNEYMOORE JD. Neutralization of murine mammary tumor virus by sera of women with breast cancer. Nature. 1971;229:627-8. CrossrefMedlineGoogle Scholar2. BLACKZACHRAUSHOREDIONLEIS MRBAH. Cellular immunity to autologous breast cancer and RIII-murine mammary tumor virus preparations. Cancer Res. 1978;38:2068-76. MedlineGoogle Scholar3. MESA-TEJADAKEYDARRAMANARAYANANOHNOFENOGLIOSPIEGELMAN RIMTCS. Detection in human breast carcinomas of an antigen immunologically related to a group-specific antigen of mouse mammary tumor virus. Proc Natl Acad Sci USA. 1978;75:1529-33. CrossrefMedlineGoogle Scholar4. DAYWITKINSARKAR NSN. Antibodies reactive with murine mammary tumor virus in sera of patients with breast cancer: geographic and family studies. Proc Natl Acad Sci USA. 1981;78:2483-7. CrossrefMedlineGoogle Scholar5. PRIORIANDERSONWILLIAMSDMOCHOWSKI EDWL. Immunological studies on human breast carcinoma and mouse mammary tumors. J Natl Cancer Inst. 1972;48:1131-5. MedlineGoogle Scholar6. IMAIYAMADASAGANAGAYOSHIHOSHINO MCSSM. Immunological cross reaction between sera from patients with breast cancer and mouse mammary tumor virus. Gan. 1979;70:63-74. MedlineGoogle Scholar7. MÜLLERZOTTERKEMMER MSC. Specificity of human antibodies to intracytoplasmic type-A particles of the murine mammary tumor virus. J Natl Cancer Inst. 1976;56:295-303. CrossrefMedlineGoogle Scholar8. NEWGARDCARDIFFBLAIR KRP. Human antibodies binding to the mouse mammary tumor virus: a non-specific reaction? Cancer Res. 1976;36:765-8. MedlineGoogle Scholar9. TOMANAKAJDOSNIEDERMEIERDURKINMESTECKY MAWWJ. Antibodies to mouse mammary tumor virus-related antigen in sera of patients with breast carcinoma. Cancer. 1981;47:2696-703. CrossrefMedlineGoogle Scholar10. WITKINSARKARGOODDAY SNRN. An enzyme-linked immunoassay for the detection of antibodies to the mouse mammary tumor virus: application to human breast cancer. J Immunol Methods. 1980;32:85-91. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MAN-CHlU POON, M. D.; MILAN TOMANA, Ph.D; WILLIAM NIEDERMEIER, Ph.D.Affiliations: University of Alabama Birmingham Veterans Administration Medical Center Birmingham, Alabama PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMouse Mammary Tumor Virus (MMTV) and MMTV-like Viruses: An In-depth Look at a Controversial IssueViruses and human breast cancerTransformation of blood monocytes to giant cells in vitro from patients with breast cancerOf mice, cats, and men: Is human breast cancer a Zoonosis?Mouse Mammary Tumor Virus-Like Viral Infection and Human Breast CancerBreast cancer incidence highest in the range of one species of house mouse, Mus domesticusHuman Endogenous Retrovirus K Does Not Encode Mouse Mammary Tumor Virus-Related Antigens in Human Breast CarcinomasHuman Monoclonal Antibodies Directed Against HuMTV Antigens from Human Breast Cancer CellsBreast Cancer and Mouse Mammary Tumor VirusCHARLES WISEMAN, M.D. 1 June 1983Volume 98, Issue 6Page: 937-938KeywordsAntibodiesAntigensBreast cancerCellsCytoplasmHematology and oncologyImmunofluorescenceSpecificity ePublished: 1 December 2008 Issue Published: 1 June 1983 PDF downloadLoading ...