tbuckley/cabot-search huggingface dataset:
Extranodal diffuse follicular center lymphoma mimicking mantle cell lymphoma of the intestine
Authors: Shigeki Tomita, Masaru Kojima, Johji Imura, Hiroshige Hori, Yoshihiko Ueda, Ayako Koitabashi, Yasunaga Suzuki, Tetsuya Nakamura, Yuichi Nakamura, Kinuko Mitani, Akira Terano, Yasuo Ohkura, Hitoshi Kawamata, Takahiro Fujimori
Journal: American Journal of Hematology (2003)

Abstract We report a case of diffuse follicular center lymphoma (FCL), which is a morphological variant of follicular lymphoma, resembling multiple lymphomatous polyposis (mantle cell lymphoma of the intestine). The patient was a 48‐year‐old Japanese man who was found, by colonoscopy, to have numerous small polypoid lesions along the entire large intestine. Abdominal computed tomography revealed hepatosplenomegaly and enlargement of multiple mesenteric lymph nodes. Histologically, the lesion was characterized by diffuse proliferation of small‐ to medium‐sized lymphocytes with cleaved nuclei in the mucosa and submucosa. Immunohistochemical studies showed that the tumor cells were CD20+, CD10+, BCL‐2+, CD5–, surface IgM–, and cyclin D1–. Moreover, a cytogenetic study showed a translocation at (14;18)(q32;q21). Finally, this case was diagnosed as diffuse FCL, although the tumor was mimicking mantle cell lymphoma. Am. J. Hematol. 74:287–289, 2003. © 2003 Wiley‐Liss, Inc.
12 DETECTION OF RESISTANT VARIANTS IN THE HEPATITIS C VIRUS NS3 PROTEASE GENE BY CLONAL SEQUENCING AT LONG-TERM FOLLOW-UP IN PATIENTS TREATED WITH BOCEPREVIR
Authors: S. Susser, N. Forestier, M.W. Welker, J. Vermehren, U. Karey, S. Zeuzem, C. Sarrazin
Journal: Journal of Hepatology (2009)
Psoriasis is independently associated with nonalcoholic fatty liver disease in patients 55 years old or older: Results from a population-based study
Authors: Ella A.M. van der Voort, Edith M. Koehler, Emmilia A. Dowlatshahi, Albert Hofman, Bruno H. Stricker, Harry L.A. Janssen, Jeoffrey N.L. Schouten, Tamar Nijsten
Journal: Journal of the American Academy of Dermatology (2013)
Serologic Markers of Epstein–Barr Virus Infection and Nasopharyngeal Carcinoma in Taiwanese Men
Authors: Yin-Chu Chien, Jen-Yang Chen, Mei-Ying Liu, Hwai-I Yang, Mow-Ming Hsu, Chien-Jen Chen, Czau-Siung Yang
Journal: New England Journal of Medicine (2001)

It is probable but unproven that Epstein–Barr virus (EBV) has a role in nasopharyngeal carcinoma. We determined whether antibodies against EBV are present before the development of nasopharyngeal carcinoma.
Book Review Epidemiology, Causes, and Prevention of Skin Diseases Edited by J.J. Grob, R.S. Stern, R.M. MacKie, and W.A. Weinstock. 370 pp. Cambridge, Mass., Blackwell Science, 1997. $195. 0-632-04256-7
Authors: Clay J. Cockerell
Journal: New England Journal of Medicine (1998)
Doctor disciplined for "grossly undertreating" pain
Authors: F. Charatan
Journal: BMJ (1999)

In what seems to be the first such action in the United States, the Oregon Board of Medical Examiners has approved a disciplinary plan for a doctor who “grossly undertreated” pain in six patients between 1993 and 1998.

The board is made up of nine doctors and two public members appointed by the governor of the state of Oregon …
Kisspeptin: a novel physiological trigger for oocyte maturation in in-vitro fertilisation treatment
Authors: Ali Abbara, Channa Jayasena, Alexander Comninos, Monica Nijher, Georgios Christopoulos, Chioma Izzi-Engbeaya, Mathini Sridharan, Shankunthala Narayanaswamy, Deborah Ashby, Mohammad Ghatei, Stephen Bloom, Anna Carby, Geoffrey Trew, Waljit Dhillo
Journal: The Lancet (2014)
Ensuring the safety of school age passengers
Authors: A. D Mickalide
Journal: BMJ (2002)

Papers p 1123

The article by Halman et al (p 1123) in this issue indicates that children of school age involved in motor vehicle crashes were less severely injured if they were wearing a seat belt, irrespective of the type of restraint or seating position in the motor vehicle.1 The authors report that school age children (4-14 years old) restrained with a seat belt were 2-10 times as safe as unbelted children and were at least as well protected as adults wearing seat belts. The findings, however, do not answer the question about whether the degree of protection afforded children by standard seat belts is sufficient, according to the authors' discussion of the limitations of the data. The national safe kids campaign in the United States and the child passenger safety community recommend that children be protected in an appropriate child restraint or booster seat rather than in a safety …
New leads on brain functioning: how we speak, hear, and see
Authors: W. Check
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aging and rationing.
Authors: J G Evans
Journal: BMJ (1991)

Infection by the neurotropic JHM strain of mouse hepatitis virus produces an acute demyelinating encephalomyelitis. While cellular immunity initially eliminates infectious virus, CNS viral persistence is predominantly controlled by humoral immunity. To better understand the distinct phases of immune control within the CNS, the kinetics of humoral immune responses were determined in infected mice. Early during clearance of the JHM strain of mouse hepatitis virus, only few virus-specific Ab-secreting cells (ASC) were detected in the periphery or CNS, although mature B cells and ASC without viral specificity were recruited into the CNS concomitant with T cells. Serum antiviral Ab and CNS virus-specific ASC became prominent only during final elimination of infectious virus. Virus-specific ASC peaked in lymphoid organs before the CNS, suggesting peripheral B cell priming and maturation. Following elimination of infectious virus, virus-specific ASC continued to increase within the CNS and then remained stable during persistence, in contrast to declining T cell numbers. These data comprise three novel findings. Rapid recruitment of B cells in the absence of specific Ab secretion supports a potential Ab-independent effector function involving lysis of virus-infected cells. Delayed recruitment relative to viral clearance and subsequent maintenance of a stable CNS ASC population demonstrate differential regulation of T and B lymphocytes within the infected CNS. This supports a critical role of humoral immunity in regulating viral CNS persistence. Lastly, altered antiviral ASC specificities following clearance of infectious virus suggest ongoing recruitment of peripheral memory cells and/or local B cell differentiation.
Reductions in Coronary Flow Under Resting Conditions in Collateral-Dependent Myocardium of Patients With Complete Occlusion of the Left Anterior Descending Coronary Artery
Authors: Djavad T. Arani, David G. Greene, Ivan L. Bunnell, Gretchen L. Smith, Francis J. Klocke
Journal: Journal of the American College of Cardiology (1984)
In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus.
Authors: C E Taylor, W Y Weiser, F B Bang
Journal: The Journal of Experimental Medicine (1981)

Genetically resistant G3H mice routinely yielded macrophages that were resistant when grown in 90% horse serum. These mice also routinely yielded macrophages that were susceptible to the same virus, MHV (PRI), in vitro after the mice had been treated with three intraperitoneal doses, of hydrocortisone. Dexamethasone and prednisolone when similarly administered also increased the susceptibility of C3H macrophages taken from the treated animal, but progesterone and testosterone did not. In addition, spleen cells from mice treated with cortisone made the resistant C3H macrophages 100 times more susceptible in vitro. Increased in vitro susceptibility induced in this way by hydrocortisone was reversed by exposure to supernatant fluid removed from cultures of concanavalin A-treated spleen cells.
A physiologically based kinetic model for lead in children and adults.
Authors: E J O'Flaherty
Journal: Environmental Health Perspectives (1998)

A physiologically based model of lead kinetics in children and adults has been developed and tested. The premises on which the physiologically based model is founded are reviewed in this paper. Because 95% or more of the body burden of lead in adults is found in the bone, bone metabolism is central to the model. Bone volumes are expressed as functions of body weight. Bone formation and resorption rates are estimated from human studies of stable labeled calcium kinetics. Cortical and trabecular bone are modeled separately, with their surface-to-volume ratios taken into account. Standardized growth curves are used to relate body weight to age. Other model features such as organ volumes and physiologic functions are related to body weight based on measurements made in human subjects over a range of ages. Calibrations of the model to two human data sets are shown, and two applications to specific research questions are illustrated. A brief comparison of the structure of this model with that of the Leggett model, and a comparison of the output of this model with that of the integrated exposure uptake biokinetic model of the U.S. Environmental Protection Agency, are also included.
Acclerated calcium nephrolithiasis
Authors: F. L. Coe
Journal: JAMA (1980)

Of 674 patients with calcium nephrolithiasis, 78 formed their stones in large numbers (average, 22 stones per patient) and at an accelerated rate (average, 172 stones per 100 patient-years). Although their stone disease was unusually severe, these patients had the common metabolic causes of stones and responded well to treatment. Patients with even the most extremely active calcium nephrolithiasis should be evaluated and managed in the same way as those with the common, less active form of the disease.
More on the Ingelfinger Rule
Authors: Arnold S. Relman
Journal: New England Journal of Medicine (1988)

WE have two policies concerned with the prior release of material being considered or scheduled for publication by the Journal: a news embargo and the so-called Ingelfinger Rule. Both policies are designed primarily to serve the interests of our readers, who are practitioners and medical investigators, but we think they benefit the public as well.The embargo is an agreement between us and representatives of the media on the timing of news stories about articles soon to appear in the Journal. It was the subject of a recent editorial.1 The Ingelfinger Rule is an understanding with authors, summarized in . . .
The Diagnosis and Treatment of Genital Herpes
Authors: Lawrence Corey
Journal: JAMA (1982)

<h3>Latency and Herpesvirus Infections</h3> The family of viruses called the herpesviruses is a fascinating and diverse group of agents. A unique, intriguing, and frustrating aspect of these agents is their ability to become latent and produce reactivation infections. While we will concentrate on the herpes simplex viruses in this article, the entire family of agents appears capable of producing latency. With both herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), there are really two different forms of viral infection. In the acute form, what we would call a productive or lytic infection, the virus is replicating, producing mature virions, taking over the cell's machinery, causing cell death, and provoking the immune responses that are associated with recent or chronic infections. With both HSV-1 and HSV-2, a latent state of viral infection is established in the dorsal spinal ganglia of the host. At present there is little evidence of
Letter: Diabetic pregnancy.
Authors: M I Drury
Journal: BMJ (1973)

made monthly during the trial but in general they were badly recorded.Complete tablet counts were obtained for all 31 Glasgow patients but for only 6 of the 61 patients attending other centres, and the influence of the regularity of taking medication could not therefore be assessed.Data from Glasgow patients indicate that relapse was more likely in those patients who did not take their medication regularly, but the number of cases from this one centre was too small for any firm conclusion to be drawn.However, it would not be too surprising if patients took medication more regularly when regularly ask-d to return unused medication at each visit to the clinic.Dr. Leff bolsters his case by referring to the clinical arrangements made in Glasgow, and this requires some clarification.One of the difficulties in conducting this trial was that a great many patients referred to the
The Cost of Institutional Review Boards in Academic Medical Centers
Authors: Jeremy Sugarman, Kenneth Getz, Jeanne L. Speckman, Margaret M. Byrne, Jason Gerson, Ezekiel J. Emanuel
Journal: New England Journal of Medicine (2005)

To the Editor: An important concern with respect to protecting human research participants is that institutional review boards (IRBs) have insufficient resources.1 However, there are few reports of the actual costs of IRB review.2–4 To estimate the cost of operating academic IRBs in 2002, we undertook a survey with the support of the Doris Duke Charitable Foundation and the Burroughs Wellcome Fund. We surveyed 121 U.S. medical schools with active IRBs; 63 representative institutions responded. Institutions documented the education, experience, and job titles of IRB staff; the composition of the IRB itself; the estimated amounts of time spent on . . .
Abstract 2291: Oncogenic hsa-miR-1323 down-regulates MYCN/ALK and reveals PAG1 as a novel tumor suppressor for neuroblastoma
Authors: Rajib Ghosh, Zaowen Chen, Danielle Patterson, Denae N. Sikorski, Eugene S. Kim, Jason M. Shohet, Preethi H. Gunaratne
Journal: Cancer Research (2012)

Abstract MicroRNAs (miRNAs) are 22-24 nucleotides non-coding RNAs that can simultaneously influence the levels of multiple target genes and therefore have the potential to strongly silence cancer gene networks. MYCN and ALK are well established oncogenes implicated in the pathogenesis and progression of neuroblastoma. Using multiple web based algorithms we have identified potential tumor suppressor miRNAs that can control the pathogenesis and/or progression of neuroblastoma by down-regulating both MYCN and ALK. We found hsa-miR-1323 as a candidate tumor suppressor for neuroblastoma. Lipofectamine based mimic transfection and lentiviral vector based over-expression of miR-1323 in cell lines led to a decrease in MYCN and ALK transcripts as well as signals from luciferase reporter constructs carrying the 3′-UTR of MYCN or ALK validating MYCN and ALK as direct targets of miR-1323. However, unexpectedly for this predicted tumor suppressor microRNA, gain of function studies for miR-1323 in neuroblastoma cell lines demonstrated increased proliferation, colony formation and tumor growth of orthotopic xenograft tumors. As SiRNA against MYCN strongly limits neuroblastoma proliferation, our data suggests that miR-1323 targets an alternative tumor suppressor pathway which by-passes the growth suppressive effects of MYCN inhibition and drives proliferation. Further bio-informatics analysis of putative miR-1323 targets pointed to PAG1 (or Cbp) as a possible tumor suppressor target of miR-1323. The transmembrane adaptor protein PAG1 inhibits proliferation driven by the Src family of kinases (SFKs) through multiple mechanisms and is a known tumor suppressor in leukemia and non-small cell lung cancers. Importantly, analysis of PAG1 in clinical cohorts of neuroblastoma reveals that low expression of PAG1 strongly correlates with poor overall survival compared to patients with high levels of PAG1 expression (p &amp;lt;0.001). We have confirmed that miR-1323 targets PAG1 transcript via qRT-PCR assays, and this is associated with increased p-ERK levels in neuroblastoma cell lines. We therefore propose that miR-1323 mediated repression of PAG1 activates the Src-dependent oncogenic pathways, overriding its effect on MYCN or ALK, and contributing to the aggressive clinical behavior of high-risk neuroblastoma. These studies further demonstrate the complexity of microRNA functions in normal and cancer cells and mandate careful evaluation of putative ‘tumor suppressive’ microRNAs as therapeutic tools. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2291. doi:1538-7445.AM2012-2291
IL-2 analogues: novel agents circumventing the expansion of T regulatory cells while promoting NK cell activation during IL-2 therapy
Authors: Geok Choo Sim, Elizabeth Grimm, ZhiMin Dai, Willem Overwijk, Patrick Hwu, Laszlo Radvanyi
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts High dose (HD) IL-2 treatment is a potent form of immunotherapy that can induce durable complete responses in a fraction of metastatic melanoma patients. Its initial purpose was to activate the expansion and anti-tumor responses of NK cells. However, the efficacy of HD IL-2 in
Morphologic evidence for coronary artery spasm in eclampsia.
Authors: T W Bauer, G W Moore, G M Hutchins
Journal: Circulation (1982)

Vascular spasm has been considered to be an important component of the eclamptic state. If this abnormal vascular reactivity affects the coronary arteries in eclampsia, one might expect to find areas of myocardial contraction band necrosis, a lesion secondary to coronary reflow after periods of no flow. We reviewed the cardiac findings in the 34 patients with fatal eclampsia (hypertension, edema, proteinuria, and convulsions without evident cause) autopsied at The Johns Hopkins Hospital since 1899, and compared each with the next pregnant or puerperal nontoxemic autopsied patient. The eclamptic patients were 15-45 years old (average 27 years). Convulsions began antepartum in 21 patients, intrapartum in eight, and postpartum in five. The hearts weighed 200-407 g (average 312 g). One heart had rheumatic valvular disease and one had myocarditis. Histologic study of heart sections showed the presence of contraction band necrosis in 12 cases (35%). The control cases included two patients with rheumatic valvular disease, two with endocarditis, two with myocarditis, two with pericarditis, and one with leukemic infiltration. Only one control patient (3%) had contraction band necrosis (p less than 0.001). The frequent occurrence of myocardial contraction band necrosis suggests that coronary artery spasm may be common in patients who die with eclampsia.
Remarks on HISTORICAL ASPECTS OF IDEAS REGARDING DROPSY
Authors: J. D. Comrie
Journal: BMJ (1928)

THE appearance of dropsy or hydrops, to give it the original Greek form of the name, is a symptom which canniot fail to attract attention, although it is probable that in a primitive state of society a person affected by a malady sufficiently severe to produce this symptom would not long survive.Dropsy is mentioned in the Ebers papyrus and on the clay tablets of medical prescriptions from ancient Assyria, with the treatment, material and magical, believed to be appropriate to the condition.Hippocrates (400 B.C.) niaturally has a good deal to say on dropsy, and he divides it into the three types of hydrops,
Extent and Reporting of Patient Nonenrollment in Influential Randomized Clinical Trials, 2002 to 2010
Authors: Keith Humphreys, Natalya C. Maisel, Janet C. Blodgett, Ingrid L. Fuh, John W. Finney
Journal: JAMA Internal Medicine (2013)

Because they assign patients to treatment conditions, randomized clinical trials (RCTs) offer unparalleled internal validity for drawing inferences about the efficacy of a medical treatment.2][3][4][5][6] The challenges of judging the clinical utility of clinical trial results are increased by poor reporting: Gross and colleagues' study of trials published in leading medical journals from 1999-2000 found that only 28% reported the proportion of screened patients who were enrolled. 7These deficiencies may have been ameliorated in the past decade because the CONSORT statement was revised in 2001 to require more complete information on the enrollment process in reports of clinical trials 8 , and because many treatment research fields have been showing greater concern about generating knowledge that better informs clinical practice.Accordingly, the present study assessed the extent to which low enrollment rates are still characteristic of widely-cited clinical trials, and whether reporting of enrollment information has improved. MethodsA Web of Science search was employed to identify the 20 most influential English-language RCTs for each of 14 prevalent chronic disorders (alcohol dependence, Alzheimer's, breast cancer, colorectal cancer, COPD, depression, diabetes, drug dependence, HIV/AIDS, hypertension, ischemic heart disease, lung cancer, nicotine dependence and schizophrenia) published from 2002-2010 (see supplementary material for search terms and citations returned).We sorted the results on citations per year rather than total citations so that recently published trials would still have the chance to rank as influential.Top-cited articles that were not RCTs (e.g., major literature reviews) were excluded.The final dataset comprised 280 studies (20 studies for each of 14 conditions).Raters double-coded the studies on the number of patients with the disorder of interest who were screened for trial eligibility, the number who were eligible, and the number of eligible None of the authors has any conflicts of interest to disclose.The authorial team gathered and analyzed the data for this study themselves.Dr. Humphreys had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
A Role for Mitochondria in Age-Related Disorders?
Authors: Joan Stephenson
Journal: JAMA (1996)

MITOCHONDRIAL diseases may hold clues to aging and an array of age-related degenerative disorders, from Alzheimer disease to heart failure, according to a leading expert on the tiny organelles that serve as the body's power plants. "We envision the plethora of progressive degenerative diseases due to mitochondrial dysfunction and aging as a continuum, [resulting from] the same process," said Douglas C. Wallace, PhD, at a recent conference in Vancouver, British Columbia, on "Genetic Susceptibility and Complex Traits," cosponsored by the journal<i>Nature Genetics</i>and the Canadian Genetics Diseases Network. Mitochondrial diseases such as Leber hereditary optic neuropathy (a maternally inherited condition resulting in adult-onset vision loss) typically have a delayed onset and progress with age. Wallace, of Emory University School of Medicine, Atlanta, Ga, said recent findings suggest that an age-related decline in the mitochondria's ability to generate energy not only helps trigger the onset of mitochondrial DNA diseases but