tbuckley/cabot-search huggingface dataset:
Chronic actinic dermatitis
Authors: R. D. R. Camp
Journal: British Journal of Dermatology (1984)

Journal Article Chronic actinic dermatitis Get access R. D. R. Camp R. D. R. Camp Institute of Dermatology, Homerton Grove, London E9 6BX Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue 2, 1 August 1984, Page 243, https://doi.org/10.1111/j.1365-2133.1984.tb04051.x Published: 01 August 1984
Longterm pancreaticobiliary diversion stimulates hyperplastic and adenomatous nodules in the rat pancreas: a new model for spontaneous tumour formation.
Authors: N H Stace, T J Palmer, S Vaja, R H Dowling
Journal: Gut (1987)

A model for spontaneous tumour formation in the rat pancreas is described that requires neither cocarcinogens nor dietary manipulation. Short term hypercholecystokininaemia, when induced by raw soya flour feeding, induces benign and malignant tumours of the rat pancreas. Pancreaticobiliary diversion (PBD) results in hypercholecystokininaemia and in the short term, pancreatic hyperplasia. Longterm PBD was done to establish whether hypercholecystokininaemia thus produced would also lead to pancreatic neoplasia. After a period of 16-21 months hyperplastic and adenomatous nodules, one of the latter showing carcinoma in situ, were found in PBD rats but not in sham operated control rats.
The 'Liver Scan' Appearance in Cholescintigraphy A Sign of Complete Common Bile Duct Obstruction
Authors: A W NOEL, M G VELCHIK, A ALAVI
Journal: Clinical Nuclear Medicine (1985)

One hundred consecutive Tc-99m IDA hepatobiliary scans were reviewed revealing 14 scans (14%), that showed nonvisualization of the common bile duct (CBD), gallbladder (GB), and small bowel (SB), but good hepatic uptake of Tc-99m IDA derivative, a pattern designated by us as “the liver scan appearance.” In 11 of 14 cases (79%), the diagnosis of complete CBD obstruction was confirmed by surgery, percutaneous transhepatic cholangiogram (PTC), endoscopic retrograde cholangiopancreatography (ERCP), and/or percutaneous needle biopsy (PBx). Common bile duct obstruction was suspected but not proven in the other three cases. The cholescintigraphic, ultrasound, PTC, ERCP, intraoperative cholangiogram, clinical, laboratory, and surgical findings are presented and correlated. The “liver scan-appearance” by cholescintigraphy should suggest a diagnosis of complete common bile duct obstruction; however, it does not specifically differentiate between stone or tumor as the cause of obstruction.
Adenovirus-Mediated Delivery of Fas Ligand Inhibits Intimal Hyperplasia After Balloon Injury in Immunologically Primed Animals
Authors: Zhengyu Luo, Masataka Sata, Thao Nguyen, Johanne M. Kaplan, Geoffrey Y. Akita, Kenneth Walsh
Journal: Circulation (1999)

Background —Adenoviral constructs have been used for studies of injury-induced vascular hyperplasia in immunologically naive laboratory animals, but their usefulness for intra-arterial gene therapy may be limited by the prevalence of preexisting immunity to adenovirus in the patient population. Here, we explored the efficacy of adenovirus-mediated transfer of Fas ligand , a cytotoxic gene with immunomodulatory properties, in inhibiting injury-induced vascular lesion formation in both naive and immunologically primed animals. Methods and Results —Lesion formation was evaluated in balloon-injured carotid arteries of naive and adenovirus-immunized rats that were infected with adenoviral constructs expressing Fas ligand (Ad-FasL), the cyclin-dependent kinase inhibitor p21 (Ad-p21), or β-galactosidase (Ad-βgal). In naive rats, Ad-FasL induced apoptosis in medial vascular smooth muscle cells and inhibited intimal hyperplasia by 60% relative to Ad-βgal–treated vessels ( P &lt;0.05), whereas the cytostatic agent Ad-p21 decreased lesion size by 58% ( P &lt;0.05). In animals preimmunized with an adenoviral vector containing no transgene, Ad-FasL significantly inhibited neointima formation (73% reduction, P &lt;0.05), but Ad-p21 failed to inhibit neointima formation relative to controls. Immunologically primed rats displayed robust T-cell infiltration in Ad-p21– and Ad-βgal–treated vessels, but T-cell infiltration was markedly attenuated in Ad-FasL–treated vessels. Conclusions —Our data demonstrate that adenovirus-mediated Fas ligand delivery can inhibit intimal hyperplasia in both immunologically primed and naive animals, whereas the efficacy of an adenovirus-mediated p21 delivery is limited to immunologically naive animals. This study documents, for the first time, the therapeutic efficacy of intravascular adenoviral gene transfer in animals with preexisting immunity to adenovirus.
Single Photon Emission Computed Tomography (SPECT) Should be Routinely Performed for the Detection of Parathyroid Abnormalities Utilizing Technetium-99m Sestamibi Parathyroid Scintigraphy
Authors: Damita L. Thomas, Twyla Bartel, Yusuf Menda, James Howe, Michael M. Graham, Malik E. Juweid
Journal: Clinical Nuclear Medicine (2009)

The current procedure guideline for performing dual-phase (DP) parathyroid scintigraphy, using technetium-99m sestamibi (Tc-99m MIBI) does not mandate the use of single photon emission computed tomography (SPECT) imaging for the detection of parathyroid adenoma (PA) or hyperplasia (PH). The aim of our study was to determine whether DP SPECT (DPS) is significantly superior to DP planar (DPP) imaging in the detection of these abnormalities, justifying its routine use with Tc-99m MIBI parathyroid scintigraphy.Thirty-six consecutive patients with biochemically-proven hyperparathyroidism who subsequently underwent surgical evaluation were studied. All patients underwent early and delayed planar and SPECT imaging at 15 and 90 minutes postinjection of 1.11 GBq (30 mCi) of Tc-99m MIBI. The sensitivity and false-positive rate of DPP and DPS Tc-99m MIBI scintigraphy were compared by retrospectively and blindly interpreting the images and comparing the results with surgical findings.All 36 patients were shown to have either 1 PA (n=27), 2 PAs (n=1), or PH (n=8). Overall, 29 adenomas and 24 hyperplastic glands were found at surgery. On a per patient basis, the sensitivity for the detection of PA or PH for DPP was 42% (15/36) compared with 67% (24/36) for DPS (P = 0.03). For the detection of PAs, the sensitivity of DPP was 54% (15/28) versus 79% (22/28) for DPS (P = 0.05), whereas for the detection of PH, the sensitivities were 0% (0/8) for DPP versus 25% (2/8) for DPS (P = 0.13). There were 2 false-positive scans using DPP versus only 1 false-positive scan with DPS, resulting in false-positive rates of 7% and 4%, respectively. The combination of DPP and DPS did not add any advantage in detecting either PA or PH compared with DPS alone.DPS is significantly more sensitive, and at least as specific, compared with DPP in detecting parathyroid abnormalities in patients with primary hyperparathyroidism and should, therefore, be routinely used when DP Tc-99m MIBI is used in this setting. An algorithm for best utilization of this technique to determine the appropriate surgical approach in patients with primary hyperparathyroidism is presented.
A Patient With an Autonomously Functioning Thyroid Nodule With Papillary Adenocarcinoma Associated With Graves?? Hyperthyroidism
Authors: MARIKO TSUBOI, CHIAKI SHIGEMASA, YOSHIHIKO UETA, AKIO YOSHIDA, KAORU KOBAYASHI, TOHRU MORI, HIROTO MASHIBA
Journal: Clinical Nuclear Medicine (1995)

A 69-year-old man had concomitant findings of an autonomously functioning thyroid papillary adenocarcinoma and Graves' hyperthyroidism. The patient presented with hyperthyroidism and a right lobe thyroid nodule that was shown to be hyperfunctional on I-123 imaging. The TI-201 imaging showed uptake confined almost entirely to the right lobe nodule. Papillary adenocarcinoma in the nodule and diffuse hyperplasia surrounding the nodule along with a slightly enlarged left lobe were found at surgery.
The Accelerated Medical Program And the Liberal Arts at Boston University
Authors: Ernest H. Blaustein
Journal: JAMA (1976)

Since September 1961, fifteen classes have matriculated in Boston University's Six- Year College of Liberal Arts--Medical Education Combined Degree Program. The applicant pool is approximately three to four times larger now than in the earlier years, with classes averaging 50 students. Academic qualifications (high-school class rank and Scholastic Aptitude Test and College Board Achievement Test results) of the entering classes have been at a consistently high level. Fifty percent or more of the graduates receive the BA degree with honors; 10% or more receive the MD degree with honors. The degree of flexibility in the liberal arts component of the program has increased and currently exceeds that of the traditional four-year premedical curriculum. These data, together with additional information concerning postgraduate professional activities, indicate that the combined accelerated program has been successful.
2014 IMPROVED INFLAMMATORY ACTIVITY WITH LOW-DOSE PEGINTRON (PEG) MAINTENANCE THERAPY IN PRIOR NONRESPONDERS WITH METAVIR FIBROSIS SCORES (MFS) OF F2/F3: FINAL RESULTS FROM THE EPIC3 PROGRAM
Authors: T. Poynard, J. Bruix, E. Schiff, M. Diago, T. Berg, R. Moreno-Otero, L.G. Lyra, F.J. Carrilho, N. Boparai, L. Griffel, M. Burroughs, C. Brass, J.K. Albrecht
Journal: Journal of Hepatology (2010)
Lymphoma in patients with dermatitis herpetiformis and their first-degree relatives
Authors: K. Hervonen, M. Vornanen, H. Kautiainen, P. Collin, T. Reunala
Journal: British Journal of Dermatology (2005)

Journal Article Lymphoma in patients with dermatitis herpetiformis and their first‐degree relatives Get access K. Hervonen, K. Hervonen Departments of Dermatology Kaisa Hervonen. E‐mail: Kaisa.Hervonen@pshp.fi Search for other works by this author on: Oxford Academic Google Scholar M. Vornanen, M. Vornanen Pathology Search for other works by this author on: Oxford Academic Google Scholar H. Kautiainen, H. Kautiainen Rheumatism Foundation Hospital, Heinola, Finland Search for other works by this author on: Oxford Academic Google Scholar P. Collin, P. Collin Internal Medicine, Tampere University Hospital, PO Box 2000, FIN‐33521 Tampere, FinlandMedical School of Tampere University, Tampere, Finland Search for other works by this author on: Oxford Academic Google Scholar T. Reunala T. Reunala Departments of DermatologyMedical School of Tampere University, Tampere, Finland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 152, Issue 1, 1 January 2005, Pages 82–86, https://doi.org/10.1111/j.1365-2133.2005.06345.x Published: 01 January 2005 Article history Accepted: 05 August 2004 Published: 01 January 2005
Radionuclide Venographic Demonstration of Portal and Systemic Collaterals in a Case of Complete IVC Obstruction
Authors: LLOYD V. GREENWALD, RAULIE RODRIGO
Journal: Clinical Nuclear Medicine (1984)

Radionuclide venography can be used to assess deep venous thrombosis and IVC obstruction. We present a case which, to our knowledge, has not been previously described, in which the entire liver and lungs are simultaneously visualized secondary to portal-caval and caval-systemic collaterals, respectively.
Increased Risk of Restenosis After Placement of Gold-Coated Stents
Authors: Adnan Kastrati, Albert Schömig, Josef Dirschinger, Julinda Mehilli, Nicola von Welser, Jürgen Pache, Helmut Schühlen, Tassilo Schilling, Claus Schmitt, Franz-Josef Neumann
Journal: Circulation (2000)

Background —Gold is a highly biocompatible material. Experimental evidence suggests that coating the stent with a gold layer may have a beneficial influence. In this randomized trial, we assessed whether gold-coated stents were associated with a better clinical and angiographic outcome after coronary placement. Methods and Results —Patients with symptomatic coronary artery disease were randomly assigned to receive either a gold-coated Inflow stent (n=367) or an uncoated Inflow stainless steel stent (n=364) of identical design. Follow-up angiography was routinely performed at 6 months. The primary end point of the study was the occurrence of any adverse clinical event (death, myocardial infarction, or target-vessel revascularization) during the first year after stenting. At 30 days, there was no significant difference in the combined incidence of adverse events, with 7.9% in the gold-stent group versus 5.8% in the steel-stent group ( P =0.25). The incidence of angiographic restenosis (≥50% diameter stenosis) was 49.7% in the gold-stent group and 38.1% in the steel-stent group ( P =0.003). One-year survival free of myocardial infarction was 88.6% in the gold-stent group and 91.8% in the steel-stent group ( P =0.14). One-year event-free survival was significantly less favorable in the gold-stent group (62.9% versus 73.9% in the steel-stent group; P =0.001). Conclusions —Coating steel stents with gold had no significant influence on the thrombotic events observed during the first 30 days after the intervention. However, gold-coated stents were associated with a considerable increase in the risk of restenosis over the first year after stenting.
An immunohistochemical study of the dermal infiltrate and epidermal staining for interleukin 1 in 12 cases of Sweet's syndrome
Authors: J. F. BOURKE, J.L. JONES, R. A. C. GRAHAM-BROWN
Journal: British Journal of Dermatology (1996)

Interleukin 1 (IL-1) has been proposed as a possible mediator in Sweet's syndrome. We examined all cases of Sweet's syndrome (n = 12) presenting to the department over a 10-year period, from 1982 to 1992, for the presence of IL-1 and also assessed the nature of the dermal inflammatory infiltrate in those cases. Staining for IL-1 alpha and IL-1 beta was stronger in control tissues than in Sweet's syndrome. This may possibly be explained by the release of IL-1 alpha and IL-1 beta into the dermis in Sweet's syndrome. Contrary to recent reports, we found that neutrophils predominated in all cases examined, although histiocytes were present in increased numbers indicating their possible role in the pathophysiology of Sweet's syndrome.
IgD multiple myeloma: A cure at 21 years
Authors: Robert A. Kyle
Journal: American Journal of Hematology (1988)

Abstract A 52‐year‐old man with a plasmacytoma of the body of T‐10 in February 1965 returned 6 months later with multiple myeloma characterized by bone pain, osteolytic lesions, and IgD λ monoclonal protein in the serum, 6.1 g of Bence Jones protein in the urine, and 21% plasma cells in the bone marrow. The M‐protein and bone pain disappeared within 6 weeks after therapy with melphalan and prednisone was started. Therapy was discontinued in December 1974. Immunoelectrophoreses and immunofixations of the serum and urine over the years revealed no monoclonal protein. A mediastinal tumor developed, and the patient died of respiratory insufficiency on October 23, 1986. Autopsy revealed a large bronchogenic carcinoma of the right lung extending to the mediastinum, trachea, and esophagus. There was no evidence of multiple myeloma. This patient had responded rapidly to chemotherapy and had no recurrence of myeloma during a 21‐year follow‐up.
Diabetes and Cholesterol Metabolism
Authors: Piia P. Simonen, Helena Gylling, Tatu A. Miettinen
Journal: Diabetes Care (2003)

Markedly increased cholesterol synthesis and low absorption of cholesterol in our obese patients with type 2 diabetes (1) prompted Dr. Ertel (2) to question whether the “succinate hypothesis” could explain the changes in cholesterol metabolism.

According to the succinate mechanism, summarized by Fahien and MacDonald (3), a basic requirement for insulin release would be the generation of mevalonic acid. This would be regulated by insulinotropic action of succinate and other nutrient secretagogues through several intracellular metabolic …
The higher expression of α and β isoforms of the human glucocorticoid receptor in leukemic B-progenitors compared to normal CD10+ BM cells does not correlate with methylprednisolone-induced apoptosis
Authors: L M M Albuquerque, A B Garcia, J O Mengel, R P Falcão, M de Castro, E M Rego
Journal: Leukemia (2004)
NITROUS OXID AND OXYGEN ANESTHESIA
Authors: HARRY G. SLOAN
Journal: JAMA (1913)

Dr. Teter, Miss Hodgins and Miss Toot of Cleveland and Dr. McKesson of Toledo have administered nitrous oxid for surgical purposes over twenty thousand times without a death from anesthesia. In the hands of the expert nitrous oxid is perhaps the safest known anesthetic, while it is perhaps the least safe in the hands of the inexpert. In equally expert hands ether may rival nitrous oxid as to immediate mortality, but ether is wholly outclassed by nitrous oxid as to the indirect postoperative morbidity and mortality. This striking difference is wholly beyond the control of the anesthetist because it rests on a chemical basis. The chemical reactions which favor nitrous oxid anesthesia and handicap ether anesthesia are the following: Nitrous oxid produces anesthesia by reason of its interference with the use of oxygen by the brain-cells; it apparently exerts no other influence except this oxygen interference; therefore its total effect
Increased house dust mite allergen in synthetic pillows may explain increased wheezing
Authors: J. Crane, T. Kemp, R. Siebers, N. Rains, D. Fishwick, P. Fitzharris
Journal: BMJ (1997)

Editor—The letter by David Strachan and Iain M Carey examining the increased risk of wheezing associated with synthetic pillows seems confusing.1 It is not clear whether they have used whole mite extract or why they used 1 mm diameter weals as a cut off point when this will include non-atopic children. However, the increased risk of wheezing associated with synthetic pillows is potentially important, given …
Peer review: reform or revolution?
Authors: R. Smith
Journal: BMJ (1997)

As recently as 10 years ago we had almost no evidence on peer review, a process at the heart of science. Then a small group of editors and researchers began to urge that peer review could itself be examined using scientific methods. The result is a rapidly growing body of work, much of it presented at the third international congress on peer review held in Prague last week. The central message from the conference was that there is something rotten in the state of scientific publishing and that we need radical reform.

The problem with peer review is that we have good evidence on its deficiencies and poor evidence on its benefits. We know that it is expensive, slow, prone to bias, open to abuse, possibly anti-innovatory, and unable to detect fraud. We also know that the published papers that emerge from the process are often grossly deficient. Research presented at the conference showed, for instance, that reports of randomised controlled trials often fail to mention previous trials and do not place their work in the context of what has gone before; that routine reviews rarely have adequate methods and are hugely biased by specialty and geography in the references they quote (p 766); and that systematic reviews rarely define a primary outcome measure.

Perhaps because scientific publishing without peer review seems unimaginable, …
Metabolic Consequences of Antihypertensive Therapy
Authors: WALTER FLAMENBAUM
Journal: Annals of Internal Medicine (1983)

The availability of pharmacologic agents has contributed to a reduction in the morbidity and mortality of hypertensive cardiovascular disease. However, antihypertensive agents are associated with changes that may adversely affect patients receiving therapy. Nutritional and metabolic consequences of antihypertensive therapy may be associated with enhanced atherosclerosis. The abnormalities in lipid metabolism, carbohydrate tolerance, and changes in the renin-angiotensin-aldosterone axis are reviewed. The mechanisms by which antihypertensive therapy causes these complications are unknown and their exact role in hypertensive cardiovascular disease remains to be elucidated. Appropriate selection of therapeutic agents and dietary manipulations may minimize the metabolic and nutritional consequences of antihypertensive therapy.
The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia
Authors: Alejandro Gutierrez, Alex Kentsis, Takaomi Sanda, Linda Holmfeldt, Shann-Ching Chen, Jianhua Zhang, Alexei Protopopov, Lynda Chin, Suzanne E. Dahlberg, Donna S. Neuberg, Lewis B. Silverman, Stuart S. Winter, Stephen P. Hunger, Stephen E. Sallan, Shan Zha, Frederick W. Alt, James R. Downing, Charles G. Mullighan, A. Thomas Look
Journal: Blood (2011)
Subintimal Dissection of Peritoneovenous Shunt Tubing Demonstration with Radionuclide Study
Authors: ROGER T. PEZZUTI, MELVIN E. CLOUSE, THOMAS C. HILL, ALBERT BOTHE, JUDITH F. KATZ
Journal: Clinical Nuclear Medicine (1985)

A case report is presented in which malfunction of a peritoneovenous shunt was caused by subintimal dissection of the venous end of the shunt tubing. The radionuclide shunt patency study demonstrated a collection of radioactivity at the venous end of the tubing, representing the abnormal intramural collection of peritoneal fluid. Scintigraphic demonstration of this complication of a peritoneovenous shunt has not been reported previously.
Silicosis among grindstone cutters in the north of Nigeria.
Authors: D A Warrell, B D Harrison, I W Fawcett, Y Mohammed, W S Mohammed, H M Pope, B J Watkins
Journal: Thorax (1975)

Many of the grindstones used in Nigerian homes are quarried from sandstone in a small group of villages near Kano in the extreme north of the country. Of an unselected group of 126 stonecutters from two of these villages 49 were found to have radiographic evidence of silicosis, with progressive massive fibrosis in 17. Those with silicosis had worked longer in the quarries than 77 whose radiographs showed no evidence of silicosis. Sixty-three per cent of the silicotics had respiratory symptoms, the commonest being breathlessness on moderate exertion. Cough was the earliest symptom in 42%. Only 35% had abnormal physical signs in the cardiorespiratory system, 18% had clearly reduced ventilatory capacity, and airways obstruction was evident in 16%. The prevalence of silicosis in these open-cast sandstone quarriers is unexpectedly high. This is probably explained by the intensity of exposure and the particular kind of sandstone being worked. Reduction of dust exposure in these quarries raises severe practical problems, but the inhabitants of this drought-ridden area can scarcely be expected to abandon their traditional livelihood.