Cromolyn Prophylaxis for Chronic Asthma
Authors: JOHN S. HYDE
Journal: Annals of Internal Medicine (1973)

Editorial Notes1 June 1973Cromolyn Prophylaxis for Chronic AsthmaJOHN S. HYDE, M.D.JOHN S. HYDE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-6-966 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince 1965 cromolyn sodium* has been subjected to extensive pharmacological and clinical investigation in animals and man. The drug has no intrinsic bronchodilator, antihistaminic, or steroid-like properties. It appears to act by protecting the mast cell membrane and inhibiting the release of spasmogenic mediators that occur during antigen-antibody reactions and when triggered by certain seemingly nonimmunological mechanisms, such as exercise or hyperventilation (1).In the treatment of asthma, cromolyn sodium is given by inhalation, by a capsule containing 20 mg of drug per dose, in a special turbo-inhaler device, the Spinhaler. A recent study has further clarified the fate of...References1. COX J: Disodium cromoglycate: mode of action and its possible relevance to the clinical use of the drug. Br J Dis Chest 65:189-204, 1971 CrossrefMedlineGoogle Scholar2. WALKER S: The fate of (14C) disodium cromoglycate in man. J Pharm Pharmacol 24:525-531, 1971 CrossrefGoogle Scholar3. Long-term study of disodium cromoglycate in treatment of severe extrinsic or intrinsic bronchial asthma in adults.. Br Med J 4:383-388, 1973 Google Scholar4. BERNSTEINSIEGELBRANDON ISM: A controlled study of cromolyn sodium sponsored by the Drug Committee of the American Academy of Allergy. J Allergy Clin Immunol 50:235-245, 1972 CrossrefMedlineGoogle Scholar5. SILVERMANANDREA JT: Time course of effect of disodium cromoglycate on exercise-induced asthma. Arch Dis Child 47:419-421, 1972 CrossrefMedlineGoogle Scholar6. GEBBIEHARRISO'DONNELL RET: Multicentre, short-term therapeutic trial of disodium cromoglycate, with and without prednisone, in adults with asthma. Br Med J 4:576-580, 1972 CrossrefMedlineGoogle Scholar7. HYDEISENBERGFLORO JPL: Short- and long-term prophylaxis with sodium in chronic asthma. Chest 63:875-880, 1973 CrossrefMedlineGoogle Scholar8. GADDIELEGGEPALMER JJK: The effect of disodium cromoglycate on pulmonary function in asthma. Br J Dis Chest 66:254-260, 1972 CrossrefMedlineGoogle Scholar9. IRANIJONESGENT FNM: Evaluation of disodium cromoglycate in intrinsic and extrinsic asthma. Am Rev Resp Dis 106:179-185, 1972 CrossrefMedlineGoogle Scholar10. SILVERMANCONNOLLYBALFOUR-LYNN MNL: Long-term trial of disodium cromoglycate and isoprenaline in children with asthma. Br Med J 3:378-381, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rush Medical Center Chicago, Illinois*Generic name in United States; known as disodium cromoglycate elsewhere. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCromolyn Sodium in the Treatment of Asthma Associated with Aspirin Hypersensitivity and Nasal PolypsDrug Evaluation DataPros and Cons of Cromolyn Sodium Prophylaxis: A Summary of Experiences with 70 Asthmatic Children 1 June 1973Volume 78, Issue 6Page: 966-966KeywordsAntigensAsthmaBronchodilatorsDrugsExerciseInhalationMast cellsProphylaxisSodium Issue Published: 1 June 1973 PDF DownloadLoading ...