Thyroid Therapy of Myxedema
Authors: PAUL H. LAVIETES
Journal: Annals of Internal Medicine (1964)

Article1 January 1964Thyroid Therapy of MyxedemaA Comparison of Various Agents with a Note on the Composition of Thyroid Secretion in ManPAUL H. LAVIETES, M.D., FRANKLIN H. EPSTEIN, M.D.PAUL H. LAVIETES, M.D.Search for more papers by this author, FRANKLIN H. EPSTEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-1-79 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWith the general tendency to use the protein bound iodine of serum (PBI) to replace basal metabolism rate (BMR) determinations, the PBI is often used as a guide to replacement therapy in hypothyroidism. This practice may be very misleading. Although when desiccated thyroid is used for treatment, the PBI tends to be in the normal range, when triiodothyronine is used, the PBI may be almost nil in adequately treated patients (1, 2). It is known less commonly that when thyroxine is used to produce the euthyroid state, the PBI tends to be at or above the upper normal range (3,...References1. ASPERSELENKOWPLAMONDON SPHACA: A comparison of the metabolic activities of 3,5,3′-triiodothyronine and 1-thyroxine in myxedema. Bull. Hopkins Hosp. 93: 164, 1953. MedlineGoogle Scholar2. RAWSONRALLPEARSONROBBINSPOPPELWEST RWJEOHJHFCD: L-triiodothyronine versus 1-thyroxine. A comparison of their metabolic effects in human myxedema. Amer. J. Med. Sci. 226: 405, 1953. CrossrefMedlineGoogle Scholar3. ROBERTSONKIRKPATRICK JDHF: Changes in basal metabolism, serum protein-bound iodine and cholesterol during treatment of hypothroidism with oral thyroid and 1-thyroxine sodium. Brit. Med. J. 1: 624, 1952. CrossrefMedlineGoogle Scholar4. STURNICKFALCON-LESSES MIM: A comparison of the effect of desiccated thyroid and sodium levothyroxine on the serum protein-bound iodine. New Engl. J. Med. 264: 609, 1961. CrossrefMedlineGoogle Scholar5. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL H. LAVIETES, M.D.; FRANKLIN H. EPSTEIN, M.D.Affiliations: New Haven, ConnecticutFrom the Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.This work was supported by a grant from the Warner-Chilcott Laboratories, Morris Plains, New Jersey, and the United States Public Health Service grant H-834, Bethesda, Maryland.Requests for reprints should be addressed to Paul H. Lavietes, M.D., 862 Howard Avenue, New Haven 11, Connecticut. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLT4 and Slow Release T3 Combination: Optimum Therapy for Hypothyroidism?The Swinging Pendulum in Treatment for Hypothyroidism: From (and Toward?) Combination TherapyThe History and Future of Treatment of HypothyroidismElizabeth A. McAninch, MD and Antonio C. 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WOOL, M.D.Thyroid Function TestsFactors affecting the determination of the serum protein-bound iodineThyroxin-Triiodothyronine Concentrations in Thyroid PowdersThe effect of triiodothyronine on neonatal hyperbilirubinemiaThyroid indices during replacement with desiccated thyroid and proloidAnomalous Effects of Certain Preparations of Desiccated Thyroid on Serum Protein-Bound Iodine 1 January 1964Volume 60, Issue 1Page: 79-87KeywordsClinical chemistryClinical laboratoriesHypothyroidismMedical servicesProtein metabolismProteinsSerum proteinsThyroidThyroxineTriiodothyronine ePublished: 1 December 2008 Issue Published: 1 January 1964 PDF downloadLoading ...