tbuckley/cabot-search huggingface dataset:
MRC trial of treating hypertension in older adults.
Authors: K. Swedberg
Journal: BMJ (1992)

Intra-arterial temazepam EDITOR,-We write to draw attention to compli- cations resulting from the new "abuse resistant"' formulation of temazepam capsules.In the past six months we-have seen 15 injecting drug misusers (13 men, two women, aged 19-35) with severe complications of intra-arterial injection (10 femoral, five brachial) of "solid" gel temazepam.Patients prepared the capsules by removing the soft gelatin shell, boiling the "solid" gel centre with water in a spoon, and injecting the warm suspension.All described instant pain in the region supplied by the injected artery.
Adenovirus Evasion of Interferon-Mediated Innate Immunity by Direct Antagonism of a Cellular Histone Posttranslational Modification
Authors: G.J. Fonseca, G. Thillainadesan, A.F. Yousef, J.N. Ablack, K.L. Mossman, J. Torchia, J.S. Mymryk
Journal: Cell Host & Microbe (2012)
Childhood Persistent Asthma after In Utero Tobacco Exposure in Mexican, Puerto Rican, and African Americans
Authors: S. Apte, H. Tcheurekdjian, C. Eng, J.R. Rodriguez-Santana, R. Rocio Chapela, H.G. Watson, K. Meade, M. LeNoir, W. Rodriguez-Cintron, P.C. Avila, E. González Burchard
Journal: Journal of Allergy and Clinical Immunology (2010)
Abstract 3786: LC3B-positive autophagosomes are a common feature of solid tumors and associated with proliferation, metastasis and poor outcome
Authors: Rossitza Lazova, Robert Camp, Summar Siddiqui, Vincent Klump, John M. Pawelek
Journal: Cancer Research (2011)

Abstract Interest in autophagy and cancer has surged in recent years. Autophagy provides a source of nutrients in times of metabolic stress. A paradox for autophagy in cancer is that while autophagy is a conserved pro-survival mechanism, it can also act in tumor suppression as is the case with the autophagy-associated beclin-1 protein. However, there is growing evidence supporting a pro-survival role for autophagy in tumor progression, for example in gastrointestinal tumors and invasive melanomas wherein autophagosomes are abundant. Here we expanded previous studies on autophagosomes in malignancies to include nearly 2000 pathology specimens from 20 different cancers, analyzing for associations of autophagosomes with tumor progression. Methods. Individual pathology specimens and tumor tissue microarrays (TMAs) were stained for the autophagosome marker LC3B and the proliferation marker Ki-67 through standard IHC procedures. Automated quantitative analyses (AQUA) used fluorescence-tagged antibodies. Results: In multitumor TMAs, about 85% of all tumors showed positive staining of LC3B in a granular pattern. In melanoma TMAs, LC3B was elevated in lymph node metastases. In breast carcinoma TMAs LC3B was elevated in node-positive compared to node-negative primaries and associated with increased nuclear grade, and worse patient outcome. LC3B and Ki-67 expression correlated in both melanoma and breast carcinoma (p &amp;lt; 0.0001), indicating a strong association between autophagy and proliferation. Supporting this, mitotic figures were largely detected in LC3B-positive tumor cells. Conclusions. While it is clear that autophagy can play a tumor suppressor role in some settings, we posit that these results are most consistent with a pro-survival role for autophagy, at least in advanced malignancies. In cancer, autophagy is thought to be part of the pro-survival integrated stress response known as aerobic glycolysis or the Warburg effect whereby cells utilize glycolysis rather than aerobic respiration for ATP production. Since some 90% of malignancies constituitively express the Warburg effect and, as shown herein, a similar number express LC3B-positive autophagosomes, the results are most consistent with autophagy being an integral, active part of this response. That autophagosomes are expressed in proliferating tumor cells further supports this proposal. In any case, the widespread occurrence of autophagosomes in cancer shown herein, and by others, underscores the importance of autophagy as a target in the design of new anti-cancer therapies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3786. doi:10.1158/1538-7445.AM2011-3786
GENDER-ASSOCIATED DIFFERENCES IN NEOINTIMAL VOLUME AFTER CORONARY ZOTAROLIMUS-ELUTING STENT IMPLANTATION: RELATIONSHIP TO RENAL FUNCTION
Authors: Osami Kawarada, Katsuhisa Waseda, Teruyoshi Kume, Kenji Sakata, Paul G. Yock, Yasuhiro Honda, Peter J. Fitzgerald
Journal: Journal of the American College of Cardiology (2011)
Nurse sentenced to life for murdering four patients
Authors: T. Sheldon
Journal: BMJ (2003)

A Dutch nurse has been sentenced to life imprisonment after being found guilty of murdering four patients and attempting to murder three others. All were children or elderly women and all were patients at three hospitals in The Hague where she worked from 1997 to 2001.

In every case Lucy de Berk, had been responsible for their care and medication or was the last person present before they died or became ill. But there were no direct witnesses and the prosecution had to rely on indirect evidence.

She …
Increase in Pulmonary Ventilation–Perfusion Inequality with Age in Healthy Individuals
Authors: JAUME CARDÚS, FELIP BURGOS, ORLANDO DIAZ, JOSEP ROCA, JOAN ALBERT BARBERÁ, RAMÓN M. MARRADES, ROBERT RODRIGUEZ-ROISIN, PETER D. WAGNER
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Arterial oxygen tension (PaO2 ) is known to decrease with age, and this is accompanied by a number of changes in mechanical properties of the lungs, including loss of elastic recoil and increase in closing volume. The changes in respiratory mechanics with age could induce greater ventilation/perfusion (V˙ a/Q˙) mismatch and thus explain the decrease in Pa O2 . In 64 normal subjects aged 18 to 71 yr (lifetime nonsmokers with normal spirometry), we measured V˙ a/Q˙ inequality and arterial respiratory blood gases (Pa O2 and PaCO2 ) at rest in the seated position. V˙ a/Q˙ mismatch, represented by the second moments of the blood flow and ventilation distributions (log SDQ and log SDV) increased with age, but only slightly (mean log SDQ was 0.36 at age 20 yr and 0.47 at age 70 yr). Pa O2 fell by a correspondingly small amount of 6 mm Hg. Previously established upper 95% confidence limits for log SDQ (0.60) and log SDV (0.65) in subjects at age 20 yr were confirmed. At age 70 yr, the upper limits of reference for log SDQ are 0.70 and for log SDV 0.75. The study shows that an increased alveolar– arterial O2 gradient with age is due to V˙ a/Q˙ inequality rather than to shunting.
Diagnostic Testing for Celiac Disease
Authors: Mario Plebani, Daniela Basso
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The extent of linkage disequilibrium in Arabidopsis thaliana
Authors: Magnus Nordborg, Justin O. Borevitz, Joy Bergelson, Charles C. Berry, Joanne Chory, Jenny Hagenblad, Martin Kreitman, Julin N. Maloof, Tina Noyes, Peter J. Oefner, Eli A. Stahl, Detlef Weigel
Journal: Nature Genetics (2002)
Characterization of the Interaction of Ingenol 3-Angelate with Protein Kinase C
Authors: Noemi Kedei, Daniel J. Lundberg, Attila Toth, Peter Welburn, Susan H. Garfield, Peter M. Blumberg
Journal: Cancer Research (2004)

Ingenol 3-angelate (I3A) is one of the active ingredients in Euphorbia peplus, which has been used in traditional medicine. Here, we report the initial characterization of I3A as a protein kinase C (PKC) ligand. I3A bound to PKC-alpha in the presence of phosphatidylserine with high affinity; however, under these assay conditions, little PKC isoform selectivity was observed. PKC isoforms did show different sensitivity and selectivity for down-regulation by I3A and phorbol 12-myristate 13-acetate (PMA) in WEHI-231, HOP-92, and Colo-205 cells. In all of the three cell types, I3A inhibited cell proliferation with somewhat lower potency than did PMA. In intact CHO-K1 cells, I3A was able to translocate different green fluorescent protein-tagged PKC isoforms, visualized by confocal microscopy, with equal or higher potency than PMA. PKC-delta in particular showed a different pattern of translocation in response to I3A and PMA. I3A induced a higher level of secretion of the inflammatory cytokine interleukin 6 compared with PMA in the WEHI-231 cells and displayed a marked biphasic dose-response curve for the induction. I3A was unable to cause the same extent of association of the C1b domain of PKC-delta with lipids, compared with PMA or the physiological regulator diacylglycerol, and was able to partially block the association induced by these agents, measured by surface plasmon resonance. The in vitro kinase activity of PKC-alpha induced by I3A was lower than that induced by PMA. The novel pattern of behavior of I3A makes it of great interest for further evaluation.
Interferon-gamma-mediated activation of STAT1alpha regulates growth factor-induced mitogenesis.
Authors: F Marra, G G Choudhury, H E Abboud
Journal: Journal of Clinical Investigation (1996)

Immunomodulatory cytokines and growth factors act in a complex network to regulate diverse biologic processes. Pre-treatment of two types of human vascular pericytes, liver fat-storing cells or glomerular mesangial cells, with IFN-gamma dramatically enhanced DNA synthesis in response to PDGF or EGF. IFN-gamma by itself had very little effect on DNA synthesis. At least 24-h exposure of the cells to IFN-gamma is required for enhancement of growth factor-induced mitogenesis. IFN-gamma pretreatment did not influence PDGF or EGF receptor autophosphorylation, activation of phospholipase Cgamma1, and phosphatidylinositol 3-kinase, or mitogen-activated protein kinase activity. However, IFN-gamma pretreatment markedly potentiated the DNA binding activity of STAT1alpha in response to PDGF or EGF. Incubation of cells with antisense oligonucleotides targeting STATlalpha mRNA resulted in inhibition of DNA synthesis induced by the combination of IFN-gamma and PDGF or EGF. These data indicate that interaction between IFN-gamma and growth factors at the level of STAT1alpha results in increased DNA synthesis, and establish a role for STAT1alpha in this important biologic function of growth factors.
ADRENALIN IN CHLOROFORM ANAESTHESIA
Authors: H. T. Depree
Journal: BMJ (1913)

TMDTrCALJOUUNqAL 879 which haemoglobin had been dded, a medium I use altogether for the isolation of the gonococcus.No gonococcus-like organisms grew on any of the media except the latter, and on this there developed a number of clharacteristic colonies, which on staining showed the usual characters of this organism.Subcultures of the pure growth mere made on the ascitic media, as well as on various others; only on the ascitic agar did any growth occur, and only a limited number of the colonies showed ability or desire to grow in subculture.Even those which did grow in subculture were very sensitive to their surroundings, and the one pure culture which I kept for stock, now in its sixty-fifth transfer, needs to be transferred every day or it will die.I have not been able to make it grow on any modification, even, of the original medium.
OT-09 * CHARACTERIZATION OF INFILTRATING MYELOID CELLS ASSOCIATED WITH XENOGRAFTED GLIOMAS IN THE RODENT BRAIN
Authors: J. Morganti, S. Liu, S. Rosi, N. Gupta
Journal: Neuro-Oncology (2015)

INTRODUCTION: Ionizing radiation, usually delivered as fractionated external beam radiotherapy, is a cornerstone of treatment for many types of brain tumors in children. However, depending on the age of the child, radiation also causes a number of late effects including progressive cognitive dysfunction. Specifically, irradiation of key structures such as the hippocampus results in the activation of inflammatory pathways, and can profoundly affect the neural structures that mediate learning and memory. METHODS: GL261 mouse glioma cells syngenic with C57/Bl6 mice were implanted into the frontal lobe of 8-12 week old mice. Tumors and normal brain tissues were examined by histology, and flow cytometry. To separate resident microglia from macrophages derived from circulating monocytes in vivo, we utilized a transgenic reporter mouse (CCR2RFP/+CX3CR1GFP/+) to accurately delineate cells based on their expression of either CX3CR1+ or CCR2+. RESULTS: We have previously shown that ionizing radiation leads to macrophage infiltration, and that mice deficient for CCR2 also have a blunted effect on cognition. In tumor bearing animals, there is a robust infiltration of peripherally derived CD11b+/F4/80+ cells into the tumor. These cells primarily express CCR2. Relative to control animals, there is also an increase in this cell population in the ipsilateral hemisphere and contralateral hemisphere. Cognitive function in tumor-bearing CCR2 knockout animals will be assessed to determine if loss of CCR2 signaling attenuates the effect of brain irradiation. CONCLUSION: An inflammatory cell population is present in increased numbers in the uninvolved brain of tumor bearing animals. This cell population plays a role in radiation-induced cognitive change and targeting this population may provide a route to ameliorate the cognitive decline observed after ionizing radiation.
Results of a Second-Opinion Program for Coronary Artery Bypass Graft Surgery
Authors: Thomas B. Graboys
Journal: JAMA (1987)

Second opinions for surgical procedures are now being sought by patients or are required by insurance carriers. We examined outcomes among 88 patients (76 men; average age, 59 years) referred for a second opinion as to the need for coronary artery bypass graft surgery. All patients had undergone coronary arteriography, which disclosed in 63 (72%) multivessel coronary artery disease, while in the remaining 25 patients single-vessel disease involved the left anterior descending coronary artery. Continuation of medical therapy was recommended for 74 (84%) of the 88 patients. Sixty of these 74 patients chose this option and continued to receive medical therapy without any fatalities during a follow-up period of 27.8 months. The remaining 14 patients elected to cross over to surgical therapy at an average of 11.3 months from the second opinion. We conclude that second opinions for selected, motivated patients slated for coronary artery bypass graft operation afford a significant and safe option. Moreover, a majority of patients will adhere to a second opinion recommending medical therapy, thus reducing the need for surgical intervention by as much as 50%. Since the study was based on a small sample size of self-selected patients, these data require caution in extrapolating to the general population with coronary artery disease.
Value of Electric-Shock Treatment on Outpatients
Authors: Robert R. Mezer, Harry C. Solomon
Journal: New England Journal of Medicine (1954)

A SURVEY of outpatient electric-shock treatment at the Southard Clinic of the Boston Psychopathic Hospital for two years (November, 1949, through October, 1951) is presented to evaluate the worth of such a program. If electric shock for outpatients is successful, it is a tremendously economical procedure, for it saves not only the expense of hospitalization, but also the loss of income from work. It avoids the stigma for the patient of being in a mental hospital, the loss of freedom, and the legal consequences, such as being deprived of a driver's license and being forced to remain in the state . . .
Biological Response to Bard Clamshell Septal Occluders in the Canine Heart
Authors: Micheal A. Kuhn, Larry A. Latson, John P. Cheatham, Bruce McManus, James M. Anderson, Karen L. Kilzer, Joseph Furst
Journal: Circulation (1996)

The Clamshell Septal Occluder has been used to close various congenital heart defects. The purpose of this study was to evaluate the long-term biological response to this device after placement in the canine heart. Previous in vivo studies with device placement were limited to 60 days.An atrial septal defect was created in dogs by blade septostomy followed by balloon dilation. Both old and new (redesigned) devices were placed. Angiographic follow-up was performed at 1, 3, and 6 months and 1 and 2 years after device placement with groups of dogs euthanitized at the same intervals. Gross and microscopic assessment was done on the explanted devices. The implants were covered at least 50% by neointima at 1 month and covered completely by 3 months. There was no thrombus formation. Areas of focal hemorrhage were evident at 1 month and were not present at 3 months. The fibrous capsule that covered the device became more densely organized and neovascularized by 2 years. A focal foreign body reaction at the device-tissue interface persisted for 2 years. There were no arm fractures with either the old or new devices in these dogs.The Bard Clamshell Septal Occluder is well tolerated in the canine heart for at least 2 years and elicits a normal healing process.
Model of outcomes of screening mammography: Spontaneous regression of breast cancer may not be uncommon
Authors: Per-Henrik Zahl, Jan Mæhlen
Journal: BMJ (2005)

Our understanding of the operation of neurons and neuronal circuits has come primarily from probing their activity in dissected, anesthetized, or restrained animals. However, the behaviorally relevant operation of neurons and neuronal circuits occurs within intact animals as they freely perform behavioral tasks. The small size and transparency of the nematode <i>Caenorhabditis elegans</i> make it an ideal system for noninvasive, optical measurements of neuronal activity. Here, we use a high signal-to-noise version of cameleon, a fluorescent calcium-binding protein, to quantify the activity of the AFD thermosensory neuron of individual worms freely navigating spatial thermal gradients. We find that AFD activity is directly coupled to the worm9s exploratory movements in spatial thermal gradients. We show that the worm is able, in principle, to evaluate and guide its own thermotactic behaviors with respect to ambient spatial thermal gradients by monitoring the activity of this single thermosensory neuron.
Clopidogrel and Long-term Outcomes After Drug-Eluting Stent Implantation
Authors: E. Liana Falcone, Navdeep Tangri
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elevated glucose alters eicosanoid release from porcine aortic endothelial cells.
Authors: M L Brown, J A Jakubowski, L L Leventis, D Deykin
Journal: Journal of Clinical Investigation (1988)

Cultured porcine aortic endothelial cells were conditioned through two passages to mimic euglycemic and hyperglycemic conditions (5.2 mM, normal glucose; 15.6 mM, elevated glucose). After incubation with 1 microM [14C]arachidonic acid for 24 h, the cells were stimulated with 1 microM A23187 for times up to 30 min. Uptake of [14C]arachidonic acid and its distribution among cell lipids were unaffected by the increased glucose concentration. The release of eicosanoids from labeled cells and unlabeled cells was measured by reverse-phase HPLC and by RIA, respectively. Compared with cells stimulated in the presence of normal glucose concentrations, cells stimulated in the presence of elevated glucose released 62.6% less free [14C]arachidonic acid, but released 129% more 14C-labeled 15-hydroxyeicosatetraenoic acid (HETE). Increased release of 15-HETE in the presence of elevated glucose in response to A23187, bradykinin, and thrombin was confirmed by RIA. A similar increase in 5-HETE release was observed by RIA after A23187 treatment. The release of both radiolabeled and unlabeled prostanoids was equal at both glucose concentrations. The data indicate that glucose may play an important role in the regulation of release and metabolism of arachidonic acid after agonist stimulation. In the presence of elevated glucose concentrations, such as those associated with diabetes mellitus, the extent and pattern of eicosanoid release from endothelial cells is markedly altered.
The Pondville State Cancer Hospital, 1927-1947
Authors: George L. Parker
Journal: New England Journal of Medicine (1948)

SHORTLY after World War I, a movement was instigated in Massachusetts to provide care and treatment for patients with cancer. For many years various persons prominent in both public and private life became interested in the problem. The health officials believed that this was outside the realm of Public Health, but the public demands for some kind of a state-wide cancer-control program were so great that the Legislature in 1926 passed an act "to promote the prevention and cure of cancer and the extension of resources for its care and treatment." The bill originally called for the expenditure of $1,500,000 . . .