tbuckley/cabot-search huggingface dataset:
Night Shift: Another Elegy
Authors: Gary Schroeder
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Collagen prolyl hydroxylase inhibitor and reduced collagen formation in cotton pellet-induced granuloma and skin wound healing in rats
Authors: Y. KUBOTA, K. FUJIWARA, I. OGATA, Y. HORI, H. OKA
Journal: British Journal of Dermatology (1985)

Journal Article Collagen prolyl hydroxylase inhibitor and reduced collagen formation in cotton pellet‐induced granuloma and skin wound healing in rats Get access Y. KUBOTA, Y. KUBOTA The Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo Search for other works by this author on: Oxford Academic Google Scholar K. FUJIWARA, K. FUJIWARA First Department of Internal Medicine Kenji Fujiwara, M.D., First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7‐3‐1 Hongo, Bunkyo‐ku, Tokyo 113, Japan. Search for other works by this author on: Oxford Academic Google Scholar I. OGATA, I. OGATA First Department of Internal Medicine Search for other works by this author on: Oxford Academic Google Scholar Y. HORI, Y. HORI The Department of Dermatology, Yamanashi Medical College, Yamanashi, Japan Search for other works by this author on: Oxford Academic Google Scholar H. OKA H. OKA First Department of Internal Medicine Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue 5, 1 November 1985, Pages 559–563, https://doi.org/10.1111/j.1365-2133.1985.tb02379.x Published: 01 November 1985 Article history Accepted: 24 May 1985 Published: 01 November 1985
Clinical Trials of HIV Vaccines
Authors: Barney S. Graham
Journal: Annual Review of Medicine (2002)

▪ Abstract Development of a preventive vaccine for HIV is the best hope of controlling the AIDS pandemic. Evidence from natural history studies and experiments in animal models indicates that immunity against HIV is possible, suggesting that vaccine development is feasible. These studies have shown that sufficient levels of neutralizing antibody against HIV can prevent infection, although the effect is type-specific. In contrast, HIV-specific cytotoxic T lymphocyte (CTL) activity has broad cross-reactivity, and although CTL activity alone cannot prevent HIV infection, it can control the level of viremia at a low level. Evaluation of candidate vaccines in human trials has focused on approaches that can safely elicit HIV-specific antibody and T cell responses. Current strategies have been unable to induce antibody with broad neutralizing activity against primary HIV isolates. However, recombinant poxvirus and DNA vaccines have elicited CTL responses that are broadly cross-reactive against primary HIV isolates from diverse clades. Future advances will require the discovery of new immunogens that can induce neutralizing antibody, as well as efficacy trial evaluation of regimens optimized for CTL induction.
Of Islands and Loss
Authors: Alexander Levering Kern
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Meeting Report: Validation of Toxicogenomics-Based Test Systems: ECVAM–ICCVAM/NICEATM Considerations for Regulatory Use
Authors: Raffaella Corvi, Hans-Jürgen Ahr, Silvio Albertini, David H. Blakey, Libero Clerici, Sandra Coecke, George R. Douglas, Laura Gribaldo, John P. Groten, Bernd Haase, Karen Hamernik, Thomas Hartung, Tohru Inoue, Ian Indans, Daniela Maurici, George Orphanides, Diana Rembges, Susanna-Assunta Sansone, Jason R. Snape, Eisaku Toda, Weida Tong, Joost H. van Delft, Brenda Weis, Leonard M. Schechtman
Journal: Environmental Health Perspectives (2005)

This is the report of the first workshop "Validation of Toxicogenomics-Based Test Systems" held 11–12 December 2003 in Ispra, Italy. The workshop was hosted by the European Centre for the Validation of Alternative Methods (ECVAM) and organized jointly by ECVAM, the U.S. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), and the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM). The primary aim of the workshop was for participants to discuss and define principles applicable to the validation of toxicogenomics platforms as well as validation of specific toxicologic test methods that incorporate toxicogenomics technologies. The workshop was viewed as an opportunity for initiating a dialogue between technologic experts, regulators, and the principal validation bodies and for identifying those factors to which the validation process would be applicable. It was felt that to do so now, as the technology is evolving and associated challenges are identified, would be a basis for the future validation of the technology when it reaches the appropriate stage. Because of the complexity of the issue, different aspects of the validation of toxicogenomics-based test methods were covered. The three focus areas include a) biologic validation of toxicogenomics-based test methods for regulatory decision making, b) technical and bioinformatics aspects related to validation, and c) validation issues as they relate to regulatory acceptance and use of toxicogenomics-based test methods. In this report we summarize the discussions and describe in detail the recommendations for future direction and priorities.
Former health secretary champions bill to legalise assisted suicide in UK
Authors: C. Dyer
Journal: BMJ (2009)

The former health secretary, Patricia Hewitt, last week called for a bill legalising assisted suicide in the United Kingdom. In the meantime she has proposed an amendment to the Suicide Act, which she has tabled as part of parliament’s current consideration of the Coroners and Justice Bill. Her amendment aims to protect from prosecution relatives and friends who help their loved ones go abroad to end their lives.

“In the long term we need a bill to change the law to allow terminally ill, mentally competent adults suffering at the end of their lives …
Ethics and Etiquette in Neonatal Intensive Care
Authors: Serena Barello, Guendalina Graffigna, Elaine C. Meyer
Journal: JAMA Pediatrics (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Evolving changes in Doppler mitral flow velocity pattern in rats with hypertensive hypertrophy
Authors: Tohru Masuyama, Kazuhiro Yamamoto, Yasushi Sakata, Reiko Doi, Nagahiro Nishikawa, Hiroya Kondo, Keiko Ono, Tsunehiko Kuzuya, Motoaki Sugawara, Masatsugu Hori
Journal: Journal of the American College of Cardiology (2000)
EFFECT OF DIRECT, ALTERNATING, TESLA CURRENTS AND X-RAYS ON BACTERIA.
Authors: F. ROBERT ZEIT
Journal: JAMA (1901)

The subject of this study is one that does not seem to have received the attention it merits. The most extravagant claims for and against the effect of various electrical currents have been made in the past. If we are to judge from the vague statements in the current text-books on bacteriology and electro-therapeutics, it becomes evident that further investigation and experimental work are necessary for a more exact knowledge of this interesting and practical subject. I have carefully examined most of the text-books on bacteriology and electro-therapeutics and find but few which mention the subject at all. On the other hand, we find in the literature numerous cases where the germicidal action of various electric currents seems to have been clinically proven, and where "electricity" is claimed to have cured certain cases. Are these cures only due to the production of antiseptics and germicides by electrolysis? Can any of
Treatment of Fractures and Dislocations, 1950–1960
Authors: Thomas B. Quigley, Henry Banks
Journal: New England Journal of Medicine (1960)

The chariots shall rage in the streets; they shall justle one another in the broad ways; they shall seem like torches; they shall run like the lightnings. Nahum 2:4 AS man controls ever increasing power and lives longer and longer, his achievements more and more bear the visage of Frankenstein's monster. On the highways of the United States alone, 40,000 deaths and 250,000 injuries occur every year. Most of the latter are peripheral, involving bones, tendons, muscles, ligaments, nerves and blood vessels. Far too many leave permanent souvenirs of disability.The afternoon of life has been amazingly prolonged. Never before . . .
Veno-Occlusive Disease of the Liver After Allogeneic Bone Marrow Transplantation
Authors: PAUL D. BERK
Journal: Annals of Internal Medicine (1979)

Acute veno-occlusive disease of the liver developed in seven of 29 patients undergoing bone marrow transplantation for treatment of leukemia, aplastic anemia, or disseminated carcinomatosis. All seven died despite successful marrow engraftment. Hepatic failure was the principal cause of death in four and contributory in three. The veno-occlusive disease did not relate to the nature of the pretransplant immunosuppressive regimen, since it occurred in patients receiving irradiation alone, chemotherapy alone, or both. Twenty-two of the patients were autopsied. Among these, the lesion was found in seven of 11 in whom a graft-versus-host reaction developed but in none of the 11 without such a reaction who had received similar pretransplant immunosuppression (P < 0.025). Hence, acute veno-occlusivedisease of the liver appears to be a complication of allogeneic bone marrow transplantation related to the development of a graft-versus-host reaction.
Abstract C06: Translation of isoform-level gene signature into robust diagnostic assay for glioblastoma subtyping
Authors: Yingtao Bi, Sharmistha Pal, Luke Macyszyn, Donald O'Rourke, Ramana Davuluri
Journal: Cancer Research (2013)

Abstract Abstract: Translating the molecular signatures from classification strategies into robust diagnostic assays is essential for cancer therapy guidance and prognosis determination. To develop a clinically applicable molecular stratification assay for Glioblastoma multiforme (GBM) with significant prognostic value, we designed a novel classification system based on isoform-level gene expression profiles; an avenue unexplored for diagnostic and prognostic use. Using isoform-level expression clustering of The Cancer Genome Atlas (TCGA) samples, we identified four GBM subgroups with significant (p=0.0103) survival differences. A four-class classifier, built with 121 transcript-variants, assigns GBM patients' molecular subtype with 92% accuracy. The classifier was translated to a high-throughput RT-qPCR assay and validated on an independent cohort of 206 glioblastoma samples. We found that proneural patients have the worst prognosis except for younger patients (&amp;lt;40 years), while a better prognosis is observed for neural group among older patients (≥40 years). The isoform-level classifier, transformed from a high-dimensional platform to a low-dimensional RT-qPCR platform, provides a quantitative and reproducible stratification of GBM patients with prognostic significance, a requirement towards personalized medicine. The resulting diagnostic assay from the classifier has immediate clinical implications towards prioritizing patients for standard care versus aggressive therapy regimen. Citation Format: Yingtao Bi, Sharmistha Pal, Luke Macyszyn, Donald O'Rourke, Ramana Davuluri. Translation of isoform-level gene signature into robust diagnostic assay for glioblastoma subtyping. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr C06.
General medicine in the 'eighties.
Authors: C Davidson, R C King
Journal: BMJ (1986)

The general physician with or without an interest is directly responsible for the initial and continuing care in most acute medicine. Specialty interests cover the whole range of medicine but in most instances are subordinate to the claims of general medicine. Consultants in district general hospitals carry a bigger caseload in acute medicine than their colleagues in teaching hospitals, and this has implications for undergraduate and postgraduate training. The management of patients in intensive care units remains very much the task of the general physician. The general physician will continue to be an essential member of the hospital service in the foreseeable future.
Inertial Navigation and Animal Navigation
Authors: John S. Barlow
Journal: New England Journal of Medicine (1965)

THE continuing appearance of papers1 2 3 4 on various aspects of the problem of animal navigation attest to the interest in this phenomenon, whose physiologic basis remains incompletely elucidated. That celestial cues (position of the sun and stars) are important for the navigation of a number of different species has become increasingly clear in recent years, but for birds, at least, it has been suggested that orientation by means of celestial cues (for example, sun-compass orientation) may be only one aspect of a more general means of navigation.5 That the earth's magnetic field might have a role in bird navigation has long . . .
Human cardiac gap-junction coupling: effects of antiarrhythmic peptide AAP10
Authors: Anja Hagen, Anna Dietze, Stefan Dhein
Journal: Cardiovascular Research (2009)

Ventricular arrhythmia is one of the most important causes of death in industrialized countries and often accompanies myocardial infarction and heart failure. In recent years modification of gap-junctional coupling has been proposed as a new antiarrhythmic principle. We wanted to examine whether the gap junction modulator (antiarrhythmic peptide) AAP10 exerts effects on human cardiac gap junctions, whether the effect might be enhanced in uncoupled cells, whether it affects electrical and metabolic coupling, and which of the cardiac connexin isoforms (Cx40, Cx43, Cx45) may be affected. We determined the influence of 50 nM AAP10 (H2N-Gly-Ala-Gly-4Hyp-Pro-Tyr-CONH2) on macroscopic gap junction conductance by dual whole-cell voltage clamping in human and rat cardiomyocytes. Cells were partially uncoupled by CO2-mediated acidosis (pH 6.3) or kept at 'normal' conditions (pH 7.4, T 36°C). Furthermore, we investigated effects of AAP10 in HeLa cells stably transfected with connexin 40, 43, or 45 and on metabolic coupling determined by dye transfer (Lucifer yellow). AAP10 (50 nM)-enhanced gap-junctional intercellular coupling in human and rat cardiomyocytes, completely prevented CO2-acidosis-induced uncoupling and improved metabolic coupling. The coupling effect of AAP10 was significantly enhanced in previously uncoupled cells. Regarding the connexin isoforms, AAP10-enhanced electrical and metabolic coupling in HeLa cells expressing Cx43 or Cx45, but not in HeLa cells expressing Cx40. We conclude that the antiarrhythmic peptide AAP10, which improves gap-junctional intercellular coupling and prevents uncoupling by acidification in human cardiomyocytes, might be useful for antiarrhythmic strategies regarding arrhythmias caused by uncoupling of Cx43 and Cx45, but not Cx40.
Combined Use of Fibrinolysin and Endarterectomy
Authors: A. B. Eisenbrey
Journal: JAMA (1961)

EFFORTS TO REESTABLISH the cerebral circulation through the carotid artery after complete occlusion of the internal carotid artery have, in our past experience, met with a notable lack of success. The exploration of carotid arteries has for some years been the practice in this and other institutions when an occlusion was demonstrated arteriographically. The usual experience has been to find the common carotid artery and the external carotid artery patent, with a large plaque present at the bifurcation of the vessels and a completely obliterative, well-organized thrombosis present in the internal carotid artery. The vessel itself in these cases has been pale, firm, and attenuated and on cross section showed no significant recanalization. More recent efforts have been directed toward the relief of stenosing lesions at the bifurcation of the common carotid artery in the presence of vascular insufficiency associated with intermittent and transient episodes of either monocular visual disturbances
Researchers Still Seek Clinical Benefit in Raising Levels of Good Cholesterol
Authors: Mike Mitka
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
First 5 years of measles elimination in southern Africa: 1996–2000
Authors: Robin Biellik, Simon Madema, Anne Taole, Agnes Kutsulukuta, Ernestina Allies, Rudi Eggers, Ntombenhle Ngcobo, Mavis Nxumalo, Adelaide Shearley, Egleah Mabuzane, Erica Kufa, Jean-Marie Okwo-Bele
Journal: The Lancet (2002)
Serum transferrin receptor in the evaluation of the iron status in elderly hospitalized patients with anemia
Authors: Etienne Joosten, Ronny van Loon, Jaak Billen, Norbert Blanckaert, Ria Fabri, Walter Pelemans
Journal: American Journal of Hematology (2001)

Abstract The aim of the present study is to evaluate in an elderly hospitalized population the diagnostic value of the serum transferrin receptor (sTfR) in distinguishing IDA (iron deficiency anemia) from ACD (anemia of chronic disease) as compared to conventional laboratory tests of iron metabolism, especially serum ferritin. In a prospective study, 34 patients with IDA and 38 patients with ACD (a chronic disorder in 23 and an acute infection in 15) were evaluated using iron status tests including serum transferrin receptor assay. The iron stores were assessed by bone marrow examination. sTfR levels were elevated (&gt;28.1 nmol/L) in 68% of the IDA patients but also in 43% of the patients with ACD‐chronic inflammation and 33% with ACD‐acute infection. Serum ferritin was the best test to differentiate IDA from ACD patients. We conclude that serum ferritin is a more sensitive and specific parameter than the sTfR assay to predict the bone marrow iron status in an elderly anemic population. Am. J. Hematol. 69:1‐6, 2002. © 2002 Wiley‐Liss, Inc.
Deep Labiomental Fold With Pseudocomedones
Authors: Liran Horev, Abraham Zlotogorski, Yuval Ramot
Journal: JAMA Dermatology (2013)

OBSERVATION Deep Labiomental Fold With PseudocomedonesThe labiomental fold is a transverse indentation of the face, which marks the intersection of the lower lip and chin. 1 It plays a significant role in movement of the lower lip and in facial expression.We describe herein a child with a linear pattern of microcomedones located along a deep labiomental fold.
Receptor-Defined Subtypes of Breast Cancer in Indigenous Populations in Africa: A Systematic Review and Meta-Analysis
Authors: Amanda Eng, Valerie McCormack, Isabel dos-Santos-Silva
Journal: PLoS Medicine (2014)

In a systematic review and meta-analysis, Isabel dos Santos Silva and colleagues estimate the prevalence of receptor-defined subtypes of breast cancer in North Africa and sub-Saharan Africa. Please see later in the article for the Editors' Summary