Rapidly Progressive Glomerulonephritis
Authors: Mark Denton
Journal: Annals of Internal Medicine (2002)

Letters3 September 2002Rapidly Progressive GlomerulonephritisMark Denton, BSc, MRCP, Colm Magee, MRCP, and John Niles, MDMark Denton, BSc, MRCPBrigham and Women's Hospital; Boston, MA 02115Massachusetts General Hospital; Boston, MA 02115Search for more papers by this author, Colm Magee, MRCPBrigham and Women's Hospital; Boston, MA 02115Massachusetts General Hospital; Boston, MA 02115Search for more papers by this author, and John Niles, MDBrigham and Women's Hospital; Boston, MA 02115Massachusetts General Hospital; Boston, MA 02115Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-5_Part_1-200209030-w1 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Rapidly progressive glomerulonephritis is a clinicopathologic syndrome defined by the development of renal failure over days to months and the appearance of crescentic glomerulonephritis (1). Two major causes of rapidly progressive glomerulonephritis are anti–glomerular basement membrane (GBM) disease and vasculitis associated with antineutrophil cytoplasmic antibodies (ANCAs). These conditions have distinct clinical, serologic, and pathologic features. Nevertheless, a proportion of patients with rapidly progressive glomerulonephritis possess both anti–GBM antibodies and ANCAs. The clinical and serologic characteristics of such patients have not been well defined, in part because of the small numbers of patients seen at any single ...References1. Rees AJ, Cameron JS. Oxford Textbook of Clinical Nephrology. Oxford, United Kingdom: Oxford Univ Pr; 1998. Google Scholar2. Short AK, Esnault VL, Lockwood CM. Anti-neutrophil cytoplasm antibodies and anti-glomerular basement membrane antibodies: two coexisting distinct autoreactivities detectable in patients with rapidly progressive glomerulonephritis. Am J Kidney Dis. 1995;26:439-45. [PMID: 7544065] CrossrefMedlineGoogle Scholar3. Bosch X, Mirapeix E, Font J, Borrellas X, Rodríguez R, López-Soto A, et al . Prognostic implication of anti-neutrophil cytoplasmic autoantibodies with myeloperoxidase specificity in anti-glomerular basement membrane disease. Clin Nephrol. 1991;36:107-13. [PMID: 1657470] MedlineGoogle Scholar4. Hellmark T, Niles JL, Collins AB, McCluskey RT, Brunmark C. Comparison of anti-GBM antibodies in sera with or without ANCA. J Am Soc Nephrol. 1997;8:376-85. [PMID: 9071706] CrossrefMedlineGoogle Scholar5. Levy JB, Turner AN, Rees AJ, Pusey CD. Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma exchange and immunosuppression. Ann Intern Med. 2001;134:1033-42. [PMID: 11388816] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Brigham and Women's Hospital; Boston, MA 02115Massachusetts General Hospital; Boston, MA 02115 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLong-Term Outcome of Anti–Glomerular Basement Membrane Antibody Disease Treated with Plasma Exchange and Immunosuppression Jeremy B. Levy , A. Neil Turner , Andrew J. Rees , and Charles D. Pusey Metrics Cited byWestern Blot Analysis for the Detection of Anti-Glomerular Basement Membrane Antibodies and Anti-Phospholipase A2 Receptor AntibodiesPulmonary vasculitis and pulmonary hemorrhage syndromesApproach to the Patient with Rapidly Progressive GlomerulonephritisCoexistence of Anti-Glomerular Basement Membrane Antibodies and Myeloperoxidase-ANCAs in Crescentic GlomerulonephritisClinical features and outcome of patients with both ANCA and anti-GBM antibodies 3 September 2002Volume 137, Issue 5_Part_1Page: W1KeywordsAntibodiesAntigensGlomerulonephritisImmunoassaysMedical dialysisProteinsSpecificityUpper respiratory tract infectionsVasculitisWestern blot ePublished: 3 September 2002 Issue Published: 3 September 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...