tbuckley/cabot-search huggingface dataset:
Enzyme Dissolution of the Nucleus Pulposus in Humans
Authors: Lyman Smith
Journal: JAMA (1964)

CHYMOPAPAIN, by direct injection into the intervertebral disc, will cause dissolution of the nucleus pulposus in rabbits without apparent effect on the surrounding tissues, such as ligaments, bone, nerve roots, and dura mater.<sup>1</sup> This technique was therefore applied to 22 dogs with paralysis of the hind legs believed to be due to herniation of intervertebral discs. Chymopapain, 1 to 5 mg, was injected directly into the discs apparently involved. Fourteen of the 22 dogs recovered to the extent of being able to stand orwalk. Seven dogs were unimproved. At autopsy, six of these dogs showed herniation or extrusion of the disc at levels other than those injected. The seventh had complete degeneration of the spinal cord below the level of the lesion. No deleterious effects of the enzyme were found in any of these animals.<sup>2</sup> With these favorable experiences as a foundation, clinical trials were started in July, 1963, on humans with sciatica secondary to herniated intervertebral discs. This report deals with the clinical
COMPARISON OF [F-18]FALLYPRIDE AND [F-18]FPMB AS HIGH AFFINITY PET RADIOTRACERS FOR DOPAMINE D-2 RECEPTORS
Authors: J Mukherjee, M K Das, Z-Y Yang, N J Yasillo, S Kronmal, T Brown, M Cooper
Journal: Clinical Nuclear Medicine (1993)

Mukherjee, J; Das, M K; Yang, Z-Y; Yasillo, N J; Kronmal, S; Brown, T; Cooper, M Author Information
Congenital Nonobstructive, Nonhemolytic Jaundice
Authors: Rafael Gorodischer, Gerhard Levy, Joseph Krasner, Sumner J. Yaffe
Journal: New England Journal of Medicine (1970)

SERUM bilirubin concentrations of newborn infants can be reduced by exposure to sunlight or artificial blue light.1 These findings have been confirmed by many investigators in this country and (especially) abroad. More recently, phototherapy has been applied in a prophylactic manner to modify the degree of hyperbilirubinemia in premature infants.2 In the case reported below phototherapy was used successfully to reduce serum bilirubin concentration in an older infant with congenital, nonobstructive, nonhemolytic jaundice unresponsive to phenobarbital therapy.Case ReportR.D.T. (C.H. 477291), an obviously icteric infant with unconjugated hyperbilirubinemia (serum bilirubin as high as 35.4 mg per 100 ml, with . . .
Quantitative systematic review of randomised controlled trials comparing antibiotic with placebo for acute cough in adults
Authors: T. Fahey, N. Stocks, T. Thomas
Journal: BMJ (1998)

<h3>Abstract</h3> <b>Objectives:</b> To assess whether antibiotic treatment for acute cough is effective and to measure the side effects of such treatment. <b>Design:</b> Quantitative systematic review of randomised placebo controlled trials. <b>Data sources:</b> Nine trials (8 published, 1 unpublished) retrieved from a systematic search (electronic databases, contact with authors, contact with drug manufacturers, reference lists); no restriction on language. <b>Main outcome measures:</b> Proportion of subjects with productive cough at follow up (7-11 days after consultation with general practitioner); proportion of subjects who had not improved clinically at follow up; proportion of subjects who reported side effects from taking antibiotic or placebo. <b>Results:</b> Eight trials contributed to the meta-analysis. Resolution of cough was not affected by antibiotic treatment (relative risk 0.85 (95% confidence interval 0.73 to 1.00)), neither was clinical improvement at re-examination (relative risk 0.62 (0.36 to 1.09)). The side effects of antibiotic were more common in the antibiotic group when compared to placebo (relative risk 1.51 (0.86 to 2.64)). <b>Conclusions:</b> Treatment with antibiotic does not affect the resolution of cough or alter the course of illness. The benefits of antibiotic treatment are marginal for most patients with acute cough and may be outweighed by the side effects of treatment. <h3>Key messages</h3> Acute cough, with or without sputum, is a common reason for consulting a general practitioner Although antibiotic treatment is common for this condition, its likely benefits and side effects have not been measured This systematic review reports the outcome of nine randomised controlled trials that compared antibiotic with placebo in patients with acute cough Resolution of cough and clinical improvement at follow up was no different in the two groups The benefits of antibiotic treatment seem to be marginal for most patients with acute cough and may be outweighed by the side effects of treatment
Syringe Needles and Mass Inoculation
Authors: A. G. Coullie
Journal: BMJ (1951)

A simple and efficient method for the dissection of (marker) chromosomes, (micro)nuclei, and chromosome regions is presented. Before microdissection, metaphases are overlaid with milli-Q water to rehydrate the chromosomes, which makes them soft and sticky. The dissected chromosome fragments are dissolved without proteinase-K or topoisomerase treatment and directly amplified using a degenerate oligonucleotide primed polymerase chain reaction (DOP-PCR). The advantages of this microFISH method over previously reported methods are: (1) microdissection in this way is very fast; (2) a chromosome, marker, (micro)nucleus, or chromosome region is collected as a whole using only one microneedle; (3) the dissected material sticks tightly to the needle without the risk of getting lost; (4) no Sequenase is used in the DOP-PCR reaction which reduces the risk of contamination.
Increased platelet thromboxane A2/prostaglandin H2 receptors in patients with acute myocardial infarction.
Authors: G W Dorn, N Liel, J L Trask, D E Mais, M E Assey, P V Halushka
Journal: Circulation (1990)

Platelets have been implicated in the formation of occlusive intracoronary thrombi leading to unstable angina pectoris and acute myocardial infarction. Evidence of platelet involvement in these syndromes includes increased thromboxane A2 synthesis during ischemic events and enhanced in vitro sensitivity to agonists. To determine the density and affinity of platelet thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptors in patients with acute myocardial infarction and unstable angina pectoris, the maximum number of binding sites (Bmax) per platelet and the dissociation constant (Kd) of the TXA2/PGH2 receptor antagonist, [125I]-PTA-OH, was determined at equilibrium in washed platelets. Patients with acute myocardial infarction had a significantly (p = 0.006) higher Bmax (4,468 +/- 672 sites/platelet, n = 9) compared with controls (2,206 +/- 203 sites/platelet, n = 8). Restudied at a time when the patients' coronary artery disease was clinically stable, Bmax values for the myocardial infarction group had returned to within normal limits. The dissociation constant for [125I]-PTA-OH was not significantly different in the acute myocardial infarction patients compared with controls. In patients with acute myocardial infarction, the duration of chest pain was positively correlated (r = 0.71, p less than 0.02) with the number of [125I]-PTA-OH binding sites (Bmax). In vitro platelet sensitivity to the TXA2/PGH2 mimetic, U46619, was assessed in aggregation studies. The maximal velocity of aggregation (slope) correlated with platelet TXA2/PGH2 receptor number (r = 0.67, p less than 0.001) and was significantly higher (p less than 0.02) in the acute myocardial infarction patients compared with the other study groups. There was no significant difference in the aggregation EC50 values for the thromboxane mimetic U46619 between unstable angina, acute myocardial infarction, and control groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Excision of Patella
Authors: R. J. Willan
Journal: BMJ (1945)

<h3>ABSTRACT</h3> Installing stable, functional mimics of phosphorylated amino acids into proteins offers a powerful strategy to study protein regulation. Previously, a genetic code expansion (GCE) system was developed to translationally install non-hydrolyzable phosphoserine (nhpSer), with the γ-oxygen replaced with carbon, but it has seen limited usage. Here, we achieve a 40-fold improvement in this system by engineering into <i>Escherichia coli</i> a biosynthetic pathway that produces nhpSer from the central metabolite phosphoenolpyruvate. Using this “PermaPhos<sup>Ser</sup>” system – an autonomous 21-amino acid <i>E. coli</i> expression system for incorporating nhpSer into target proteins – we show that nhpSer faithfully mimics the effects of phosphoserine in three stringent test cases: promoting 14-3-3/client complexation, disrupting 14-3-3 dimers, and activating GSK3β phosphorylation of the SARS-CoV-2 nucleocapsid protein. This facile access to nhpSer containing proteins should allow nhpSer to replace Asp and Glu as the go-to pSer phosphomimetic for proteins produced in <i>E. coli</i>.
Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma
Authors: S S Wang, M J Maurer, L M Morton, T M Habermann, S Davis, W Cozen, C F Lynch, R K Severson, N Rothman, S J Chanock, P Hartge, J R Cerhan
Journal: Leukemia (2008)
Dermoscopy in general dermatology: practical tips for the clinician
Authors: A. Lallas, J. Giacomel, G. Argenziano, B. García-García, D. González-Fernández, I. Zalaudek, F. Vázquez-López
Journal: British Journal of Dermatology (2013)

In addition to its well-documented value in improving the diagnosis of skin tumours, dermoscopy is continually gaining appreciation in the field of general dermatology. Dermoscopy has been shown to facilitate the clinical recognition of several inflammatory and infectious diseases, as well as their discrimination from skin tumours. Moreover, recent data indicate that it might also be profitable in assessing the outcome and adverse effects of various treatments. Application of dermoscopy should follow the standard procedure of acquiring information from patient history and clinically evaluating the number, location and morphology of the lesion(s). Four parameters should be assessed when applying dermoscopy in the realm of inflammatory and infectious diseases: (i) morphological vascular patterns; (ii) arrangement of vascular structures; (iii) colours; and (iv) follicular abnormalities, while the presence of other specific features (clues) should also be evaluated. It must be underlined that dermoscopic findings should always be interpreted within the overall clinical context of the patient, integrated with information from the history and the macroscopic examination. With new evidence continuously being gathered, the dermatoscope gradually acquires a role similar to the stethoscope of general practitioners, becoming an irreplaceable clinical tool for dermatologists. In this article, we provide a succinct summary of existing data on dermoscopy in general dermatology. Practical tips are suggested, which can assist clinicians in profitably utilizing and applying the available knowledge in their everyday practice.
Passing of Sectarianism in Medicine—The Position of the New York State Medical Association.
Authors: Frederick Holmes Wiggin
Journal: JAMA (1901)

New York City, Dec. 10, 1901. <h3>To the Editor:</h3> —I was very much interested in an editorial from the St. Paul<i>Medical Journal</i>, which appeared inThe Journal, November 16, 1901, entitled "The Passing of Sectarianism in Medicine," and I would like to call the attention of your readers to the advanced position taken by the reorganized New York State Medical Association on this subject. The only requirements for membership in this organization are that a physician shall be legally registered, shall be in good standing, and a resident of the State of New York. These requirements would seem to cover the points made in the editorial to which I have already referred, allowing, as they do, any legally registered physician in this state,<i>no matter</i>from<i>what school</i>he may have graduated, to become a member of the Association, provided only that the applicant calls himself simply a physician,
NICE should produce guidance on infant mental health
Authors: S. A Gracias
Journal: BMJ (2008)

I read the summary of the latest guidance from the National Institute for Health and Clinical Excellence (NICE) on attention-deficit/hyperactivity disorder (ADHD) with a mounting sense of dismay.1 I would like to highlight the increasing neuroscientific evidence of the impact that a child’s early environment, particularly in the context of the developing attachment relationships with …
Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity
Authors: Jorge R. Almeida, Delphine Sauce, David A. Price, Laura Papagno, So Youn Shin, Arnaud Moris, Martin Larsen, Gianfranco Pancino, Daniel C. Douek, Brigitte Autran, Asier Sáez-Cirión, Victor Appay
Journal: Blood (2009)
Polarized Secretion of Lysosomes at the B Cell Synapse Couples Antigen Extraction to Processing and Presentation
Authors: Maria-Isabel Yuseff, Anne Reversat, Danielle Lankar, Jheimmy Diaz, Isabelle Fanget, Paolo Pierobon, Violaine Randrian, Nathanael Larochette, Fulvia Vascotto, Chantal Desdouets, Bertrand Jauffred, Yohanns Bellaiche, Stéphane Gasman, François Darchen, Claire Desnos, Ana-Maria Lennon-Duménil
Journal: Immunity (2011)
Hyperthermic Biology and Cancer Therapies
Authors: Donald S. Coffey, Robert H. Getzenberg, Theodore L. DeWeese
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lymphocytotoxic Antibody in Inflammatory Bowel Disease
Authors: Stanley J. Korsmeyer, Ralph C. Williams, I. Dodd Wilson, Robert G. Strickland
Journal: New England Journal of Medicine (1975)

The prevalence of lymphocytotoxic antibody in inflammatory bowel disease is 40 per cent. Twenty-seven of 90 relatives of 23 probands with the disease (30 per cent) demonstrated lymphocytotoxic antibody, as contrasted with only three of 69 control family members (4 per cent) (P less than 0.0001). Decreased lymphocytotoxicity against lymphocytes from patients with inflammatory bowel disease as compared to normal donor lymphocytes previously demonstrated in the serum of probands was also observed in the serums from family members of the probands. Nineteen of the 48 household contacts of probands (40 per cent) were positive for antibody, whereas eight of 42 nonhousehold contacts (19 per cent) demonstrated it (P less than 0.05). Eight of 16 spouses (50 per cent) of probands showed antibody. The increased prevalence of lymphocytotoxic antibody in family members of probands and its occurrence mainly in household contacts (consanguineous and non-consanguineous) may indicate the exposure of probands and their family members to a common environmental agent.
NEUROPSYCHIATRIC ASPECTS OF ACUTE POLIOMYELITIS
Authors: JIMMIE C. B. HOLLAND, MARTIN R. COLES
Journal: American Journal of Psychiatry (1957)

1. A neuropsychiatric study of 108 hospitalized patients with acute poliomyelitis was made during the Boston epidemic of 1955. Of these, 46 patients were in respirators, 48 had paralytic poliomyelitis not requiring a respirator, and 14 had non-paralytic poliomyelitis. 2. A delirium was observed in 17 patients who were acutely ill with bulbar or bulbospinal poliomyelitis. This delirium was characterized clinically by a varying level of consciousness, pleasurable hallucinatory experiences and frequent illusions and delusions. There was waxing and waning of disorientation and confusion with a shortened attention span. Imaginary experiences were often described by patients as "wakeful" or "vivid dreams." The delirium occurred with the acute toxic phase of illness and lasted an average of two weeks followed by complete recovery in those patients who survived. 3. Psychological responses to acute poliomyelitis were studied in an attempt to delineate specific mechanisms involved. Rationalization, denial, and regression were often observed and have been described. The occurence of anxiety and depression at various stages of the disease is noted and discussed. 4. The role of a psychiatrist as part of a hospital polio team is emphasized(5).
Persistent Vomiting as a Cause of Eartroubles
Authors: C. Atkin
Journal: BMJ (1887)

exactly happened you do not know.It may be that the exudation upon the valves has been removed, or it may be that it has become, through lapse of time, so contracted, hard and smooth, as to be no longer capable of producing a murmur, or of influencing adversely the cardiac action.But, anyhow, the murmur is gone, and nothing remains to tell the story of former disease.But these recoveries from valvular inflammations are not confined to the young; they happen sometimes in the old; and I shall now furnish you with a few illustrations of both.CASE vII.-Twelve years ago I saw, with Dr. Murray, in Portland Place, a young lady, about 17, who was suffering from a severe attack of rheumatic fever.A few days after I first saw her, she had an attack of endocarditis, accompanied by increased swelling in the
Neuroarthistory: From Aristotle and Pliny to Baxandall and Zeki
Authors: Helen Bynum
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Half-Wall
Authors: William Rafelson, Theresa Brown
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Traumatic Laceration of the Aorta
Authors: Frederick B Rogers
Journal: New England Journal of Medicine (2004)

A 37-year-old man was involved in a motor vehicle collision. On examination in the emergency department, the patient was hemodynamically stable but had a steering-wheel imprint on the anterior chest wall. A computed tomographic scan of the chest showed a ruptured thoracic aorta just distal to the ligamentum arteriosum (Panel A, cross-sectional view, arrow; Panel B, sagittal view, arrow). The patient underwent emergency repair of his injury and replacement of the injured aorta with a prosthetic graft. He recovered uneventfully and was discharged eight days after surgery.
Bleeding - not always a sign of relapse of long-standing colitis
Authors: C. van der Woude, H. van Dekken, E. Kuipers
Journal: Endoscopy (2007)

A 63-year-old woman with long-standing ulcerative colitis was seen in our outpatient clinic because she had bloody diarrhea and had lost 3 kg in weight, a similar pattern to previous episodes of colitis. Surveillance colonoscopy with biopsy 6 months previously had shown active left-sided inflammation but no other abnormalities. An oral course of prednisolone at that time led to remission.
The Effect of Somatostatin on Coagulation and Platelet Function in Man
Authors: C. Harold Mielke, John E. Gerich, Mara Lorenzi, Eva Tsalikian, Robert Rodvien, Peter H. Forsham
Journal: New England Journal of Medicine (1975)

Preliminary evidence has suggested that somatostatin might interfere with platelet function in the baboon. Because this agent is currently being administered experimentally to human beings, we studied its effect on coagulation and platelet function in man. In five subjects, a four-hour infusion of somatostatin (500 micrograms per hour) had no definite effect on platelet count, leukocyte count, hematocrit, platelet adhesiveness and aggregation, bleeding time, partial thromboplastin time, prothrombin time, and fibrinogen levels. A similar infusion for 18 hours in three subjects was likewise without effect. These studies indicate that somatostatin does not affect coagulation and platelet function in man and that its prolonged administration lacks ostensible toxicity.
THE COMPARATIVE VALUE OF THE NEWER TESTS FOR ALBUMIN IN URINE.
Authors: CHARLES W. PURDY
Journal: JAMA (1884)

Although the mere presence of albumin in urine can no longer be regarded as anything further than presumptive evidence of damaged kidneys; yet, it has so long formed the basis upon which the diagnosis of renal pathology has been constructed, and, moreover, as an element considered with other symptoms it still holds, and is likely to hold, an important place at least in preliminary investigations of renal disease. Therefore, all matters concerning the most reliable and ready methods of detecting the presence of albumin in urine must remain of practical interest and importance to the general practitioner. Much attention has been given of late to several newly proposed agents for detecting albumin in urine, both in this country and in Europe. Some of these, it has been claimed, are so exceedingly delicate in reaction as to detect the presence of albumin when the older methods, as by heat and nitric