Asymptomatic Primary Systemic Amyloidosis
Authors: ROBERT A. LEVINE
Journal: Annals of Internal Medicine (1962)

Article1 March 1962Asymptomatic Primary Systemic AmyloidosisROBERT A. LEVINE, M.D., MARY ANN PAYNE, M.D., F.A.C.P., PETER M. BURKHOLDER, M.D.ROBERT A. LEVINE, M.D.Search for more papers by this author, MARY ANN PAYNE, M.D., F.A.C.P.Search for more papers by this author, PETER M. BURKHOLDER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-3-397 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough more than a century has passed since Virchow first described amyloidosis (1), investigation of its pathogenesis has been limited by the paucity of pathological material available during the early stages of its development. Hypotheses regarding pathogenesis of amyloidosis have heretofore been derived from morphologic studies, staining reactions, and immunologic techniques performed on specimens of tissue obtained in the end stages of the disorder.The authors have had the opportunity to perform studies on a series of blood samples and specimens of tissue obtained over a one-year period from a patient with amyloidosis unassociated with a predisposing disease, before the...References1. VIRCHOW R: Die Cellularpathologie in Ihrer Begründung auf Physiologische und Pathologische Gewebelehre, 1st ed., A. Hirschwald, Berlin, 1858, p. 330. Google Scholar2. BENNHOLD H: Über die auscheidung intavenös einverleibten Kongorotes bei den verscheidensten erkrankungen insbesondere bei Amyloidosis. Deutsch. Arch. Klin. Med. 142: 32, 1923. Google Scholar3. OUCHTERLONY #: Diffusion-in-gel methods for immunological analysis. Progr. Allergy 5: 1, 1958. MedlineGoogle Scholar4. SCHEIDEGGER JJ: Une micro-méthode de l'immuno-électrophorèse. Int. Arch. Allergy 7: 103, 1955. CrossrefGoogle Scholar5. KORNGOLD L: Personal communication. Google Scholar6. COONSLEDUCCONNOLLY AHEHJM: Studies on antibody production. I. A method for the histochemical demonstration of specific antibody and its application to the study of the hyperimmune rabbit. J. Exp. Med. 102: 49, 1955. CrossrefMedlineGoogle Scholar7. KLEINBURKHOLDER PP: Ein Verfahren zur fluoreszenzoptischen Darstellung der Komplementbindung und seine Anwendung zur histo-immunologischen Untersuchung der experimentellen Nierenanaphylaxie. Deutsch. Med. Wschr. 84: 2001, 1959. CrossrefMedlineGoogle Scholar8. BURKHOLDER PM: Unpublished observations. Google Scholar9. CALKINSCOHENLARSEN EASB: Amyloidosis: Preliminary clinical, chemical, and experimental observations. Ann. N. Y. Acad. Sci. 86: 1033, 1960. CrossrefMedlineGoogle Scholar10. WOLFHITZIGOTANI RLWMS: Amyloidosis unassociated with a predisposing disease. Arch. Intern. Med. 95: 141, 1955. CrossrefGoogle Scholar11. VASQUEZDIXON JJFJ: Immunohistochemical analysis of amyloid by the fluorescence technique. J. Exp. Med. 104: 727, 1956. CrossrefMedlineGoogle Scholar12. TEILUM G: Periodic acid-Schiff-positive reticuloendothelial cells producing glycoprotein: functional significance during formation of amyloid. Amer. J. Path. 32: 945, 1956. MedlineGoogle Scholar13. LETTERERCAESERVOGT ERA: Studien zur elektronenoptischen und immunmorphologischen Struktur des Amyloids. Deutsch. Med. Wschr. 85: 1909, 1960. CrossrefMedlineGoogle Scholar14. EKLUNDREIMANN CMHA: The etiology of amyloid disease: with a note on experimental renal amyloidosis. Arch. Path. 21: 1, 1936. Google Scholar15. HUESTISJAEGER DWEA: Studies on serum proteins, glycoproteins, and sialic acid in experimental amyloidosis. Arch. Path. 70: 166, 1960. MedlineGoogle Scholar16. EISEN HN: Primary systemic amyloidosis. Amer. J. Med. 1: 144, 1946. CrossrefMedlineGoogle Scholar17. GILESCALKINS RBE: The relationship of serum hexosamine, globulins, and antibodies to experimental amyloidosis. J. Clin. Invest. 37: 846, 1958. CrossrefMedlineGoogle Scholar18. RICHTER GW: Alterations in serum globulins during formation and resorption of amyloid in rabbits. J. Exp. Med. 104: 847, 1956. CrossrefMedlineGoogle Scholar19. LOSPAULLUTOCHEGORIANSKYLEWISEZIFF JJAM: Chromatographic behavior of gamma globulin: behavior of serum gamma macroglobulins. J. Clin. Invest. 39: 473, 1960. CrossrefMedlineGoogle Scholar20. CALKINSCOHEN EAS: Similarity of serum protein changes in primary and secondary amyloidosis. (Abstract) J. Clin. Invest. 38: 993, 1959. Google Scholar21. LARSEN B: Presence of glycoprotein in secondary amyloid deposits related to serum glycoproteins. Acta Rheum. Scand. 3: 30, 1957. CrossrefGoogle Scholar22. FABER M: The serum glucosamine with particular regard to its significance in connection with the origin of amyloid deposits. Acta Med. Scand., Supp. 206: 351, 1948. Google Scholar23. WILLIAMSLAW RCDH: Serum complement in amyloidosis. J. Lab. Clin. Med. 56: 629, 1960. MedlineGoogle Scholar24. WINDRUMKRAMER GMH: Some observations on the histochemical reactions of amyloid. Arch. Path. 63: 373, 1957. Google Scholar25. WAGNER BM: Histochemical studies of fibrinoid substances and other abnormal tissue proteins. IV. Protein character of amyloid. Arch. Path. 60: 221, 1955. Google Scholar26. MELLORSORTEGA RCLG: Analytical pathology. III. New observations on the pathogenesis of glomerulonephritis, lipoid nephrosis, periarteritis nodosa, and secondary amyloidosis in man. Amer. J. Path. 32: 455, 1956. MedlineGoogle Scholar27. CALKINSCOHENGITLIN EASD: Immunochemical determinations of gamma globulin content of amyloid. (Abstract) Fed. Proc. 17: 431, 1958. Google Scholar28. BRAUNSTEINBUERGER HL: A study of the histochemical and staining characteristics of amyloid. Amer. J. Path. 35: 791, 1959. MedlineGoogle Scholar29. VASQUEZDIXON JJFJ: Immunopathology of hypersensitivity. Ann. N. Y. Acad. Sci. 86: 1025, 1960. CrossrefMedlineGoogle Scholar30. VOGTKOCHEM AH: Histo-serologische Untersuchungen mit fluoresceinmarkiertem Antikomplement: Nachweis Komplementbindender Substanzen im Amyloid. Z. Zellforsch. 52: 640, 1960. CrossrefMedlineGoogle Scholar31. OSSERMAN EF: Plasma-cell myeloma. II. Clinical aspects. New Engl. J. Med. 261: 1006, 1959. CrossrefMedlineGoogle Scholar32. HEPTINSTALLJOEKES RPAM: Renal amyloidosis: a report on eleven cases proven by renal biopsy. Ann. Rheum. Dis. 19: 126, 1960. CrossrefMedlineGoogle Scholar33. BELL ET: Amyloid disease of the kidney. Amer. J. Path. 9: 185, 1933. MedlineGoogle Scholar34. WALDENSTRÖM H: On the formation and disappearance of amyloid in man. Acta Chir. Scand. 63: 479, 1928. Google Scholar35. BROUETCHRÉTIENLEGRAIN GJM: As cited by Heptinstall and Joekes in reference 32. Google Scholar36. LEVINEPAYNE RAMA: Hepatic amyloidosis with features of both amyloid and paramyloid. (Abstract) Gastroenterology 40: 566, 1961. Google Scholar37. SYMMERS WS: Amyloidosis: five cases of primary generalized amyloidosis and some other unusual cases. J. Clin. Path. 9: 212, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New YorkFrom the Departments of Medicine and Pathology, The New York Hospital-Cornell Medical Center, New York, N. Y.Requests for reprints should be addressed to Robert A. Levine, M.D., Department of Internal Medicine, Yale University, 333 Cedar Street, New Haven 11, Conn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAllergic Renal DiseasesEXPERIMENTAL AMYLOIDOSIS USING SILVER NITRATE - ELECTRON MICROSCOPIC STUDY ON THE RELATIONSHIP BETWEEN SILVER GRANULES, AMYLOID FIBRILS AND RETICULOENDOTHELIAL SYSTEM -Immunofluorescence in the study of amyloid nephrosisAmyloidosisPrimary amyloidosisGastrointestinal manifestations of amyloidosisPATHOGENESIS OF AMYLOIDOSISDermatomyositis Complicated by Generalized AmyloidosisAmyloid disease of the liver 1 March 1962Volume 56, Issue 3Page: 397-408KeywordsAmyloidosisBloodC-reactive proteinsImmunohistochemistryPathogenesisPathogensRenal analysisStaining Issue Published: 1 March 1962 PDF DownloadLoading ...