tbuckley/cabot-search huggingface dataset:
CELLS INVOLVED IN THE IMMUNE RESPONSE
Authors: Nabih I. Abdou, Maxwell Richter
Journal: The Journal of Experimental Medicine (1969)

Rabbits were made immunologically tolerant to either human serum albumin or bovine gamma globulin by the neonatal administration of antigen. At 10 wk of age, they were challenged with the tolerogenic antigen and found to be non-responsive. However, these tolerant rabbits could respond with humoral antibody formation directed toward the tolerogenic antigen if they were treated with normal, allogeneic bone marrow or bone marrow obtained from a rabbit made tolerant toward a different antigen. They were incapable of responding if they were given bone marrow obtained from a rabbit previously made tolerant to the tolerogenic antigen. Irradiated rabbits were unable to respond if treated with tolerant bone marrow, but could respond well if given normal bone marrow. Since it has previously been demonstrated that the antibody-forming cell, in an irradiated recipient of allogeneic bone marrow, is of recipient and not donor origin, the data presented strongly indicate that the unresponsive cell in the immunologically tolerant rabbit is the antigen-reactive cell.
Postoperative Uses of Hypnosis
Authors: Edward R. Robbins
Journal: JAMA (1966)

To the Editor:—  The paper by Drs. Smedley and Barnes Postoperative Use of Hypnosis on a Cardiovascular Service ( 197 :37, 1966) invites comment from one who has been using hypnosis in psychiatry and psychosomatic problems for 15 years.  The authors are to be commended for their clear and succinct discussion of the possible place of medical hypnosis in a nonpsychiatric setting. Their post-surgical patient, with hiccups of seven days' duration, was hypnotized and given minimal suggestion, mainly that he could start breathing normally as soon as he  fit. Within eight hours, he saw fit to do so. The authors, modestly, allow for the possibility of coincidence.  The profession, including psychiatrists, has continued to resist hypnosis despite a plethora of exposure since World War II. The obvious explanation is that the returns aren't great enough or often enough. And yet, medical hypnosis refuses to undergo atrophy from disuse. Quite the
Study lacks rigour to determine choice of hip resurfacing or arthroplasty
Authors: S. Oussedik, S. Konan, F. Haddad
Journal: BMJ (2012)

Although Costa and colleagues’ prospective randomised study comparing total hip arthroplasty with resurfacing arthroplasty was laudable in orthopaedics, it lacks the necessary rigour and detail to reach useful conclusions.1

Costa and colleagues do not describe the surgical approach used, and this may have a clinically significant impact on outcome.2 At least one of them favours a trans-trochanteric approach, which …
Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation
Authors: Daniel H. Fowler, Miriam E. Mossoba, Seth M. Steinberg, David C. Halverson, David Stroncek, Hahn M. Khuu, Frances T. Hakim, Luciano Castiello, Marianna Sabatino, Susan F. Leitman, Jacopo Mariotti, Juan C. Gea-Banacloche, Claude Sportes, Nancy M. Hardy, Dennis D. Hickstein, Steven Z. Pavletic, Scott Rowley, Andre Goy, Michele Donato, Robert Korngold, Andrew Pecora, Bruce L. Levine, Carl H. June, Ronald E. Gress, Michael R. Bishop
Journal: Blood (2013)
An Address on the Collective Investigation of Disease
Authors: J. Paget
Journal: BMJ (1883)

gation ;-I mean a set of casem whos life is nothing but ailment.Their physiology, if I may so express it, is a state of patholo.AIher nervous systems are so sensitive, and thelr digsUom s0 feeble, that they know nothing of that satisfactory reistans to disturbing causes from without, which we call health; and who often safer as much from futile attempts tocure them, as from their eongenital defects.
TCT-743 To Predilate or To Not Predilate In Transcatheter Aortic Valve Implantation? Single-Center Experience With Self-Expandable CoreValve Revalving System
Authors: Gennaro Giustino, Matteo Montorfano, Azeem Latib, Vasileios F. Panoulas, Alaide Chieffo, Paola Spatuzza, Georgina Fuertes Ferre, Eustachio Agricola, Pietro Spagnolo, Remo D. Covello, Ottavio Alfieri, Antonio Colombo
Journal: Journal of the American College of Cardiology (2014)
The future of bariatrics: endoscopy, endoluminal surgery, and natural orifice transluminal endoscopic surgery
Authors: N. Tsesmeli, D. Coumaros
Journal: Endoscopy (2010)

This review considers the evolving role of endoscopic techniques in the treatment of obesity, and developments in minimally invasive procedures in endoscopy, endoluminal surgery and natural orifice transluminal endoscopic surgery (NOTES). Endoscopic approaches that are similar to surgery but less invasive, relying on gastric restriction and/or malabsorption, show some promise. Intragastric injection of botulinum toxin is also considered, as is the role of minimally invasive bariatric endoscopic interventions. Gastrointestinal stimulation with implanted electrodes may have potential in the treatment of obesity and endoscopic applications have a role to play in post-surgical interventions. Evolving research into endosurgical approaches is described. Current work on the feasibility of a NOTES approach to bariatric procedures is described.
Union's legal challenge to health white paper will be heard in October
Authors: C. Dyer
Journal: BMJ (2010)

The legal challenge by the public service union Unison to the UK government’s plans for a shake-up of the NHS in England is to go ahead in the High Court on 13 October.

The UK’s biggest public service union is challenging plans by the government, outlined in a white paper in July ( BMJ 2010;341:c3796, 14 Jul, doi:10.1136/bmj.c3796), for radical changes that include giving GPs control of their own health budgets and abolishing local primary care trusts.

Unison contends that moves to start implementing Equity and Excellence: Liberating the NHS …
Modest reversal of metabolic syndrome manifestations with vitamin D status correction: a 12-month prospective study
Authors: Nasser M. Al-Daghri, Khalid M. Alkharfy, Yousef Al-Saleh, Omar S. Al-Attas, Majed S. Alokail, Abdulaziz Al-Othman, Osama Moharram, Emad El-Kholie, Shaun Sabico, Sudhesh Kumar, George P. Chrousos
Journal: Metabolism (2011)
Scabies infestation of a basal cell carcinoma
Authors: K.S. Leslie, T.H.W. Barker, J.J. Garioch
Journal: British Journal of Dermatology (2004)

An 89‐year‐old lady presented with a 4‐month history of a widespread itchy rash, which started on her hands. On examination, she had a secondarily infected dermatitic eruption affecting all of the body, including the head and neck. In addition, an ill‐defined pearly papule was noted on the right cheek. A skin biopsy was taken from the papule (Fig. 1). The haematoxylin and eosin stain shows a scabies mite encased in the stratum corneum (marked X), overlying an infiltrative basal cell carcinoma (BCC) extending into the dermis. The patient was treated with two applications of 5% permethrin cream (1 week apart) to the whole body, including the head and neck. The BCC was treated with single fraction radical radiotherapy. The patient made an unremarkable recovery from both conditions. Now we routinely treat all patients infested with scabies with 5% permethrin cream, including the head. Fortunately, treatment failure is rare.
Bacterial Contamination of Dialysing Fluid of Artificial Kidney
Authors: E. E. Kidd
Journal: BMJ (1964)

<h3>Abstract</h3> <h3>Aim</h3> The present study aims to extend the knowledge of the neural correlates of emotion processing in first episode subjects affected by anorexia nervosa (AN) or bulimia nervosa (BN). We applied an emotional distress paradigm targeting negative emotions thought to be relevant for interpersonal difficulties and therapeutic resistance mechanisms. <h3>Methods</h3> The current study applied a neuroimaging paradigm eliciting affective responses to 44 female participants with newly diagnosed AN or BN and 20 matched controls. The measurements also included an extensive assessment comprised of clinical scales, neuropsychological tests, measures of emotion processing and empathy. <h3>Results</h3> AN and BN did not differ from controls in terms of emotional response, emotion matching, self-reported empathy and cognitive performance. However, scores of eating disorder and psychopathological clinical scores, as well alexithymia levels, were increased in AN and BN. On a neural level, no significant group differences emerged, even when focusing on a region of interest selected a priori: the amygdala. <h3>Conclusions</h3> Our data are against the hypothesis that participants with AN or BN display a reduced emotional responsiveness. This supports the hypothesis that relational difficulties, as well as therapeutic resistance, are not secondary to simple difficulty in feeling and identifying basic negative emotions in AN and BN participants.
HIGH SENSITIVE TROPONIN PREDICTS LONG–TERM PROGNOSIS IN PATIENTS WITH AORTIC STENOSIS
Authors: Anoop S. Shah, Shirjel Alam, Jo Cowell, David McAllister, Marc Dweck, Jeremy P. Langrish, Edwin Carter, Mary Stoddart, Amanda Hunter, Nikhil Joshi, Nick Boon, David Newby, Nicholas L. Mills
Journal: Journal of the American College of Cardiology (2013)
Limulus assay for bacterial endotoxin in synovial fluid.
Authors: T Cesario, M Jason, B S Andrews, E Shanbron, D Juranas, L Katz, G J Friou
Journal: Annals of the Rheumatic Diseases (1983)

The limulus assay for the detection of bacterial endotoxin has been applied to the study of synovial fluid. Three of 5 patients (60%) with culture-positive gonococcal arthritis had positive SF limulus assay results; as did 2 of 11 (18%) with presumptive evidence of gonococcal arthritis, 3 of 6 (50%) with nongonococcal infectious arthritis, and none of 47 patients with noninfectious arthritis. Endotoxin levels ranged from 0.25 to 128.0 ng/ml. As at present applied to synovial fluid the commercial limulus assay appears to be specific for the infectious process but apparently lacks sensitivity.
Human Immunodeficiency Virus Antigenemia
Authors: John P. Phair
Journal: JAMA (1987)

The article by Kessler et al 1 in this issue ofThe Journaldescribes the acute illness associated with human immunodeficiency virus (HIV) infection in four individuals. Of interest was the detection of HIV antigenemia during the course of this self-limited illness before enzyme-linked immunosorbent and Western blot assays for antibody to HIV became positive. The presence of circulating antigen thus helped to establish the diagnosis.  Other investigators 2 have reported that HIV antigenemia precedes seroconversion in an unknown proportion of acutely infected individuals. The evidence available to date suggests that the circulating antigen contains the core protein of the HIV (p24) and possibly other epitopes of the virus, and that when antibody to the p24 component of the virus increases to measurable concentrations in serum or plasma, the antigen can no longer be detected. 3 In some individuals, months to years after infection, anti-p24 concentrations fall in association with
Bronchial asthma at high altitude: a clinical and laboratory study in Addis Ababa.
Authors: B Teklu
Journal: Thorax (1989)

In a study designed to throw light on the natural history of asthma in Ethiopia, 91 patients living at 2500 metres and attending asthma clinics in Addis Ababa underwent spirometric and skinprick testing. Only eight had had symptoms of asthma before the age of 16. Sixty two had a history of allergic rhinitis and 16 had a family history of allergic rhinitis; 33 had a family history of asthma. In 30 cases asthma was worse from August to October. All patients had tried traditional remedies, usually without success; and all took modern drugs, oral combination bronchodilators being the most frequently used.
Surveillance of Elderly Hospital Patients for Pulmonary Tuberculosis
Authors: R. B. Cole, J. P. Balmer, T. S. Wilson
Journal: BMJ (1974)

A restrospective study of pulmonary tuberculosis in a general hospital showed that the diagnosis had been frequently overlooked in the middleaged or elderly because the patient also suffered from a more acute condition which preoccupied the attention of the doctor. The commonest error was to discount chest x-ray abnormalities by omitting sputum culture or serial radiography. Surveillance was carried out on all patients aged 60 or over admitted to a large general hospital whose routine chest radiograph showed signs of possible pulmonary tuberculosis whether apparently active or inactive. Three sputum samples from each patient were examined for Mycobacterium tuberculosis without reference to the clinical presentation. In a nine-month period six out of 81 patients proved to have active pulmonary tuberculosis (7·4%). It is suggested that this may be a useful method of screening the elderly hospital population for pulmonary tuberculosis.
The Unremarkable Brown Recluse Spider Bite
Authors: Richard S. Berger
Journal: JAMA (1973)

Severe cutaneous necrosis is reported commonly as a consequence of Loxosceles spider bites; however, the description of mild cutaneous reactions has been neglected. Knowledge of each extreme will increase our clinical awareness of Loxosceles envenomation. Failure to recognize the mild spider bites has led to inaccurate conclusions regarding prevalence and treatment.
AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice
Authors: Yu Li, Shanqin Xu, Maria M. Mihaylova, Bin Zheng, Xiuyun Hou, Bingbing Jiang, Ogyi Park, Zhijun Luo, Etienne Lefai, John Y.-J. Shyy, Bin Gao, Michel Wierzbicki, Tony J. Verbeuren, Reuben J. Shaw, Richard A. Cohen, Mengwei Zang
Journal: Cell Metabolism (2011)
Post-extrasystolic left ventricular peak pressure with and without left ventricular failure
Authors: J. P. MERILLON, G. MOTTE, M. C. AUMONT, C. MASQUET, Y. LECARPENTIER, R. GOURGON
Journal: Cardiovascular Research (1979)

18 patients without valvular pathology, coronary artery disease, or idiopathic hypertrophic subaortic stenosis were haemodynamically and angiographically investigated in order to analyse the effects of a ventricular extrasystolic beat upon the post-extrasystolic left ventricular peak pressure. In eight normal patients (group I), the post-extrasystolic peak pressure (P.ES.P.P.) was lower than that of the pre-extrasystolic beat; in 10 patients with symptoms of left ventricular failure (group II) the P.ES.P.P. significantly increased. The reasons are: 1) cardiac origin: stroke volume increased more in group II; 2) arterial origin. a) aortic compliance was lower in group II (this is probably related to the older age of patients in group II), and by decrease in end-diastolic aortic pressure was smaller in group II. Part of this arterial effect (2b) may probably be explained from the fact that post-extrasystolic compensatory pauses are equal in both groups, but the decay time of arterial pressure during diastole (assuming an exponential decay) is larger in group II. At the same age and with the identical aortic compliance only the two factors 1 and 2b play a part in the changes in P.ES.P.P.
THE TREATMENT OF TYPHOID FEVER IN CHILDREN.
Authors: HENRY E. TULEY
Journal: JAMA (1901)

The writer intends to advance nothing new nor original in the treatment of typhoid fever in infancy, but rather to chronicle those remedies and measures which have, in a somewhat limited experience, proven most valuable in the care of these cases. Some time ago the occurrence of typhoid fever in infancy was denied by many authorities, but numerous cases have been recorded by competent observers in the last few years, in which it has occurred in very young babies and many in children under 10 years of age. Its frequency then in infancy and childhood is generally acknowledged. In watching the cases of typhoid fever in children coming under the writer's observation, the futility of attempting to care for them without skillful and careful nursing has early been a forcible conclusion. Absolute rest in bed in the recumbent position is the first essential in the treatment of this disease and
Authors' reply to Aspinall and Dunne and colleagues
Authors: D. Patel, V. Scott, J. Pilcher
Journal: BMJ (2012)

Our article was intended to provide an overview of the imaging options available for the characterisation of incidental focal liver lesions.1 It was aimed mainly at primary care and, as Aspinall rightly points out, a different investigative algorithm should be applied to a more select population at high risk …
Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma
Authors: Yong-Geun Kwak, Chang H. Song, Ho K. Yi, Pyoung H. Hwang, Jong-Suk Kim, Kyung S. Lee, Yong C. Lee
Journal: Journal of Clinical Investigation (2003)

Phosphatase and tensin homologue deleted on chromosome ten (PTEN) is part of a complex signaling system that affects a variety of important cell functions. PTEN blocks the action of PI3K by dephosphorylating the signaling lipid phosphatidylinositol 3,4,5-triphosphate. We have used a mouse model for asthma to determine the effect of PI3K inhibitors and PTEN on allergen-induced bronchial inflammation and airway hyperresponsiveness. PI3K activity increased significantly after allergen challenge. PTEN protein expression and PTEN activity were decreased in OVA-induced asthma. Immunoreactive PTEN localized in epithelial layers around the bronchioles in control mice. However, this immunoreactive PTEN dramatically disappeared in allergen-induced asthmatic lungs. The increased IL-4, IL-5, and eosinophil cationic protein levels in bronchoalveolar lavage fluids after OVA inhalation were significantly reduced by the intratracheal administration of PI3K inhibitors or adenoviruses carrying PTEN cDNA (AdPTEN). Intratracheal administration of PI3K inhibitors or AdPTEN remarkably reduced bronchial inflammation and airway hyperresponsiveness. These findings indicate that PTEN may play a pivotal role in the pathogenesis of the asthma phenotype.
PGD in 47,XXY Klinefelter's syndrome patients
Authors: C. Staessen
Journal: Human Reproduction Update (2003)

The use of ICSI has been a major breakthrough in the treatment of male infertility. Even azoospermic patients with focal spermatogenesis in the testis, may benefit from the ICSI technique in order to father a child. As ICSI use has become more common, centres have introduced infertility treatment for Klinefelter patients. To date, 34 healthy children have been born using ICSI without PGD, and the conception of one 47,XXY fetus has been reported. In view of the possible risk of an increased gonosome number in the spermatozoa of Klinefelter patients, a safer approach—offering these couples ICSI combined with PGD—has been used, and has resulted in the birth of three healthy children. Couples in which the male suffered from Klinefelter's syndrome were first treated in 1995; these patients were offered ICSI + PGD using FISH technology, notably to enumerate the X and Y chromosomes. ICSI + PGD was performed in 32 cycles of 20 couples with spermatozoa originating from a fresh ejaculate (n = 1), testicular biopsy (n = 21) or frozen–thawed testicular biopsy (n = 10). Normal fertilization occurred in 56.0 ± 22.4% of the successfully injected oocytes. On day 3 of development, 119 embryos from 29 cycles were of sufficient quality to undergo biopsy and subsequent PGD; a positive result was obtained in 113 embryos. Embryos were available for transfer in 26 cycles, with a mean of 1.6 ± 0.6 embryos per transfer. Eight pregnancies were obtained, and five resulted in a delivery. A total of 113 embryos from couples with Klinefelter's syndrome was compared with 578 embryos from control couples with X‐linked disease where PGD was used to determine gender. A significant fall occurred in the rate of normal embryos for couples with Klinefelter's syndrome (54.0%) compared with controls (77.2%). Moreover, a significantly increased risk of abnormalities was observed for sex chromosomes and autosomes; for each autosome separately, this reached significance level for chromosomes 18 and 21 only. Hence, a cautious approach is warranted in advising couples with non‐mosaic Klinefelter's syndrome. Moreover, the use of ICSI + PGD or prenatal diagnosis should be carefully considered.
Inspiratory resistance decreases limb blood flow in COPD patients with heart failure
Authors: Gaspar R. Chiappa, Paulo J.C. Vieira, Daniel Umpierre, Ana Paula S. Corrêa, Danilo C. Berton, Jorge P. Ribeiro, J. Alberto Neder
Journal: European Respiratory Journal (2013)

Chronic heart failure (CHF) with reduced left ventricular ejection fraction is a common and disabling comorbidity of chronic obstructive pulmonary disease (COPD) [1].Understanding the mechanisms underlying exercise intolerance is paramount to providing a rationale to effectively rehabilitate the fastgrowing population of patients with COPD plus CHF.
From the National Institutes of Health
Authors: B. Healy
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal