tbuckley/cabot-search huggingface dataset:
Abstract 3224: Pre-clinical targeting of the metabolic phenotype of lymphoma by AZD3965, a selective inhibitor of monocarboxylate transporter 1 (MCT1)
Authors: Susan E. Critchlow, Lorna Hopcroft, Lorraine Mooney, Nicola Curtis, Nicky Whalley, Haihong Zhong, Armelle Logie, Mitchell Revill, Liang Xie, Jingchuan Zhang, De-Hua Yu, Clare Murray, Paul D. Smith
Journal: Cancer Research (2012)

Abstract Introduction - The metabolic phenotype of tumours (relative to most normal tissues) is shifted from oxidative phosphorylation to aerobic (Warburg Effect) or anaerobic glycolysis. This enables tumours to meet their energetic and biosynthetic demands even under conditions of low nutrient and O2. The end-product of glycolysis is lactate, a metabolic dead end, which if allowed to accumulate in the tumour cell may cause feedback inhibition of glycolysis and intra-cellular acidification resulting in inhibition of cell growth or survival. Experimental data - We have studied the effects of a potent, selective and orally available inhibitor of MCT1 in lymphoma cell lines and in vivo models. AZD3965 is a small molecule inhibitor of MCT1 with a binding affinity of 1.6 nM, is 6 fold selective over MCT2 and does not inhibit MCT4 at 10 μM. Both lactate transport and cell growth are potently inhibited by AZD3965 in lymphoma cell lines that preferentially express MCT1. Lactate transport inhibition in some cell lines also induces a cytotoxic effect. In vitro combination studies show that lactate transport inhibition can enhance the induction of cell death by doxorubicin. Blocking lactate transport in vitro also leads to a rapid inhibition of glucose uptake in the Raji Burkitt's lymphoma cell line. In vivo, AZD3965 is well tolerated and induces a dose and time dependent accumulation of lactate in the tumours, suppresses tumour growth and in the Raji model potentiates the effects of Rituxan, doxorubicin and bendamustine. Conclusions - Here we demonstrate that selective inhibition of lactate transport by the MCT1 inhibitor AZD3965 offers an novel mechanism for targeting the metabolic phenotype in tumours that preferentially express MCT1. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3224. doi:1538-7445.AM2012-3224
Glycogenin-1 Deficiency and Inactivated Priming of Glycogen Synthesis
Authors: Ali-Reza Moslemi, Christopher Lindberg, Johanna Nilsson, Homa Tajsharghi, Bert Andersson, Anders Oldfors
Journal: New England Journal of Medicine (2010)

Glycogen, which serves as a major energy reserve in cells, is a large, branched polymer of glucose molecules. We describe a patient who had muscle weakness, associated with the depletion of glycogen in skeletal muscle, and cardiac arrhythmia, associated with the accumulation of abnormal storage material in the heart. The skeletal muscle showed a marked predominance of slow-twitch, oxidative muscle fibers and mitochondrial proliferation. Western blotting showed the presence of unglucosylated glycogenin-1 in the muscle and heart. Sequencing of the glycogenin-1 gene, GYG1, revealed a nonsense mutation in one allele and a missense mutation, Thr83Met, in the other. The missense mutation resulted in inactivation of the autoglucosylation of glycogenin-1 that is necessary for the priming of glycogen synthesis in muscle.
Vascular Adventitial Fibrosis in a Patient Taking Methysergide Maleate
Authors: James F. Regan
Journal: JAMA (1968)

Adventitial fibrosis of mesenteric vessels with luminal narrowing and subsequent infarction of a segment of small bowel occurred in a 51-year-old woman who was treated with methysergide maleate for vascular headaches. Following the resection of the gangrenous bowel, the resumption of drug therapy was accompanied by intermittent claudication, which disappeared when it was discontinued.
927-35 Internal Atrial Defibrillation: Need for Concomitant Pacemaker Therapy and Its Effect on Pacemaker Function
Authors: Atul Prakash, Ryszard B. Krol, Irakli Giorgberidze, Philip Mathew, Luc Mongeon, Nadeem Haque, Sankar Varanasi, Sanjeev Saksena
Journal: Journal of the American College of Cardiology (1995)
Deletion of vanilloid receptor 1_expressing primary afferent neurons for pain control
Authors: Laszlo Karai, Dorothy C. Brown, Andrew J. Mannes, Stephen T. Connelly, Jacob Brown, Michael Gandal, Ofer M. Wellisch, John K. Neubert, Zoltan Olah, Michael J. Iadarola
Journal: Journal of Clinical Investigation (2004)

Control of cancer, neuropathic, and postoperative pain is frequently inadequate or compromised by debilitating side effects. Inhibition or removal of certain nociceptive neurons, while retaining all other sensory modalities and motor function, would represent a new therapeutic approach to control severe pain. The enriched expression of transient receptor potential cation channel, subfamily V, member 1 (TRPV1; also known as the vanilloid receptor, VR1) in nociceptive neurons of the dorsal root and trigeminal ganglia allowed us to test this concept. Administration of the potent TRPV1 agonist resiniferatoxin (RTX) to neuronal perikarya induces calcium cytotoxicity by opening the TRPV1 ion channel and selectively ablates nociceptive neurons. This treatment blocks experimental inflammatory hyperalgesia and neurogenic inflammation in rats and naturally occurring cancer and debilitating arthritic pain in dogs. Sensations of touch, proprioception, and high-threshold mechanosensitive nociception, as well as locomotor function, remained intact in both species. In separate experiments directed at postoperative pain control, subcutaneous administration of RTX transiently disrupted nociceptive nerve endings, yielding reversible analgesia. In human dorsal root ganglion cultures, RTX induced a prolonged increase in intracellular calcium in vanilloid-sensitive neurons, while leaving other, adjacent neurons unaffected. The results suggest that nociceptive neuronal or nerve terminal deletion will be effective and broadly applicable as strategies for pain management.
The scientific basis for the use of biomechanical foot orthoses in the treatment of lower limb sports injuries--a review of the literature.
Authors: T E Kilmartin, W A Wallace
Journal: British Journal of Sports Medicine (1994)

While it is documented that many overuse injuries of the lower limb can be relieved with the use of biomechanical foot orthoses, what remains unclear is how an orthosis can produce this effect. A review of the literature indicates that biomechanical orthoses will reduce rearfoot movement, but the effect on knee function is negligible and the clinical significance of excessive rearfoot movement is yet to be proven. While many athletes may potentially benefit from the use of biomechanical orthoses, further research is necessary to justify and, if indicated, promote the use of biomechanical foot arthoses by athletes suffering from overuse injuries.
Cost of Containment
Authors: Harold Nachimson
Journal: JAMA (1982)

<h3>To the Editor.—</h3> I was recently involved in a rather eye-opening example of how cost can escalate to an extreme. I treated a patient at my office who had three discrete plantar warts on his left foot. I outlined what my procedure would be to remove them, and the patient asked what the cost would be. I also gave the various alternatives that were available to him. He stated quite emphatically that his insurance company would pay only if he were hospitalized for this procedure. I estimated what the cost would be if he were hospitalized on a day-surgical basis for removal of three plantar warts, and even I was surprised at the estimated cost. The day-surgery operating room, recovery room, drugs, anesthetics, agents, and dressing would amount to between $350 to $380. This procedure would be done with a local anesthetic and did not include any services of an
Variants of the inosine triphosphate pyrophosphatase gene are associated with reduced relapse risk following treatment for HCV genotype 2/3
Authors: Karolina Rembeck, Jesper Waldenström, Kristoffer Hellstrand, Staffan Nilsson, Kristina Nyström, Anna Martner, Magnus Lindh, Gunnar Norkrans, Johan Westin, Court Pedersen, Martti Färkkilä, Nina Langeland, Mads Rauning Buhl, Kristine Mφrch, Peer Brehm Christensen, Martin Lagging
Journal: Hepatology (2014)

The present study evaluated the impact of variations in the inosine triphosphate pyrophosphatase (ITPase) gene (ITPA) on treatment outcome in patients with hepatitis C virus (HCV) genotype 2/3 infection receiving peginterferon-α2a and lower, conventional 800 mg daily dose of ribavirin. Previous studies using higher, weight-based ribavirin dosing report that patients carrying polymorphisms encoding reduced predicted ITPase activity show decreased risk of ribavirin-induced anemia but increased risk of thrombocytopenia, with no impact on elimination of virus. In all, 354 treatment-naïve HCV genotype 2/3-infected patients, enrolled in a phase III trial (NORDynamIC), were genotyped for ITPA (rs1127354 and rs7270101). Homo- or heterozygosity at Ars1127354 or Crs7270101 , entailing reduced ITPase activity, was observed in 37% of patients and was associated with increased likelihood of achieving sustained virological response (SVR) (P = 0.0003 in univariate and P = 0.0002 in multivariate analyses) accompanied by a reduced risk of relapse among treatment-adherent patients. The association between ITPA variants and SVR remained significant when patients were subdivided by the 12- and 24-week treatment duration arms, HCV genotype, fibrosis stage, and IL28B genotype, and was not secondary to improved adherence to therapy or less pronounced anemia. Gene variants predicting reduced predicted ITPase activity were also associated with decreased risk of anemia (P < 0.0001), increased risk of thrombocytopenia (P = 0.007), and lower ribavirin concentrations (P = 0.02). These findings demonstrate a novel ribavirin-like association between polymorphisms at ITPA and treatment efficacy in chronic hepatitis C mediated by reduced relapse risk. We hypothesize that patients (63%) being homozygous for both major alleles, leading to normal ITPase activity, may benefit more from the addition of ribavirin to present and future treatment regimens for HCV in spite of concomitant increased risk of anemia.
Study finds disparity in care after heart attack
Authors: S. Gottlieb
Journal: BMJ (1999)

Some people who have had heart attacks die because hospitals around the United States are not using simple, proved treatments such as giving patients aspirin, a new study has found.

A research team led by Dr Gerald T O'Conner of the Dartmouth Medical School in Hanover, New Hampshire, found that substantial geographic variations exist in the treatment of patients with acute myocardial infarction, and these gaps between knowledge and practice are increasing …
The Pharmacopeia of the United States of America (The United States Pharmacopeia)
Authors: Joseph B. Jerome
Journal: JAMA (1960)

The 16th Revision of the Pharmacopeia of the United States of America has taken significant steps toward making this publication fulfill its objectives as a compendium of legal standards for the purity and potency of drugs which are included. The prime criterion for inclusion is that a drug be a medicinal substance, the utility of which is fully established and well understood. In this connection, it is important to note that the inclusion of patent drugs, begun with the 12th revision, has been greatly extended in the present edition. A study of the interim admissions, the totally new admissions to this edition, and the deletions from the previous revision indicates the intensive efforts of the Committee of Revision in attempting to make this publication adequately represent current medicinal practice. The individual carefully prepared monographs incorporate new analytical techniques and indicate the care taken to eliminate ambiguities in test procedures. At
Eating for Good Health
Authors: Lester S. King
Journal: JAMA (1964)

The author, professor of nutrition at the Harvard School of Public Health, has for several years conducted a syndicated column, on "Food and Your Health." His writings have been clearly directed to the layman, authoritative, highly readable, and deservedly popular. Long an enemy of food fads of whatever type, he has constantly stressed the sound nutritional principles which the public often ignores. Now Dr. Stare collects many of his syndicated remarks into a compact volume. The coverage is surprisingly complete and the arrangement orderly and logical. General principles of nutrition, the basic foods, appropriate modes of preparation, particular needs at different stages of development, special food factors, obesity and its associated problems, food fads, are some of the major topics considered. There are tables of calories; a useful glossary which defines the technical terms in lay language; a collection of questions and answers that deal with some specific problems; and
Life Expectancy of College Oarsmen
Authors: Curtis Prout
Journal: JAMA (1972)

For 100 years, college rowing has been accused of producing injury and early death. Earlier studies indicated that rowing was safe, and that athletics do not injure the heart or shorten life. One hundred seventy-two varsity oarsmen, when compared with random controls, lived longer. The factors contributing to this longevity do not include height, social class, or educational level.
The Civilian Psychiatrist and the Draft
Authors: IRA M. FRANK, FREDERICK S. HOEDEMAKER
Journal: American Journal of Psychiatry (1970)

A study of 11 patients who presented with psychiatric symptoms after receiving induction or activation notices revealed that their chief motivation was to obtain a letter recommending deferment. The authors discuss the ethical question of psychiatrists' volunteering their services to young men seeking deferment to express their own opposition to the Viet Nam conflict and offer suggestions to the civilian psychiatrist who is called on to evaluate a patient for the draft.
On the Care and Feeding of the Faculty
Authors: George L. Engel
Journal: New England Journal of Medicine (1969)

Abstract If medical students participate in the planning of educational programs, they will be confronted with some realities of academic life, and they will be challenged to assume some responsibility for nurturing and developing the excellent faculty they so ardently desire. They must be warned against the current enthusiasm for simplistic solutions, notably the expectation that the educational process of becoming a physician can be accelerated by the identification of "cores," by demonstration of immediate relevance, by clinical assignments before the basic disciplines have been mastered or by establishment of "specialty tracks" during the undergraduate curriculum. The function of the basic-science teaching, which provides the "languages" necessary to understand patients and disease, must be contrasted with that of clinical experience, which enables the student to assume the role of the physician. Insufficient attention has been paid by curriculum committees to identifying which "languages" are essential, and how much time in each clinical discipline is necessary to achieve the physician role.
Nicorandil preserves collateral circulation even at low systemic pressure in comparison with nitroglycerin: real-time myocardial contrast echocardiographic study
Authors: Akiko Iwata, Fuminobu Ishikura, Kentaro Ohtani, Juri Okazaki, Hideo Hirayama, Yasushi Kashiwagi, Sachiko Yagura, Tsutomu Toshida, Toshihiko Asanuma, Shintaro Beppu
Journal: Journal of the American College of Cardiology (2002)
Abstract LB-173: Statin use and colorectal adenoma risk: Results from the Adenoma Prevention with Celecoxib (APC) trial
Authors: Monica Marie Bertagnolli, Meier Hsu, Ernest T. Hawk, Craig J. Eagle, Ann G. Zauber
Journal: Cancer Research (2010)

Abstract Discussant: John A. Baron, Dartmouth Medical School, Lebanon, NH. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-173.
Cigarette Smoking and Ulcerative Colitis
Authors: Hershel Jick, Alexander M. Walker
Journal: New England Journal of Medicine (1983)

HARRIES et al. recently reported that cigarette smokers were less likely to have ulcerative colitis than nonsmokers.1 Bureš et al. have observed a similar association.2 Harries' paper was followed by an extraordinary case report by de Castella, on a young woman in whom ulcerative colitis developed after she had stopped smoking cigarettes.3 On numerous subsequent occasions, signs and symptoms of the disease disappered when the woman started smoking and reappeared when she stopped. Roberts and Diggle reported a similar case in a woman with ulcerative colitis, who was asymptomatic while smoking and whose symptoms returned within 48 to 72 hours . . .
Perinatal Vascular Changes in Coarctation of the Aorta with Distal Patent Ductus Arteriosus
Authors: RICHARD L. NAEYE
Journal: Circulation (1961)

Infants with severe coarctation of the aorta and patent ductus arteriosus develop an increased pulmonary arterial muscle mass and hypertrophy of the right ventricle during fetal life. Much of this arterial muscle mass is retained after birth. The development of the systemic arterial bed is normal during both periods.
Safety and Effectiveness of Bevacizumab-Containing Treatment for Non–Small-Cell Lung Cancer: Final Results of the ARIES Observational Cohort Study
Authors: Thomas J. Lynch, David R. Spigel, Julie Brahmer, Neal Fischbach, Jennifer Garst, Mohammad Jahanzeb, Priya Kumar, Regina M. Vidaver, Antoinette J. Wozniak, Susan Fish, E. Dawn Flick, Larry Leon, Sebastien J. Hazard, Michael P. Kosty
Journal: Journal of Thoracic Oncology (2014)
TCT-35 The Length of Stay in Hospital after Primary Percutaneous Coronary Intervention for ST-elevation Myocardial Infarction: a data from KAMIR registry
Authors: Shin Eun Lee, Jay Young Rhew, Myung Ho Jeong, Dong-yob Lee, Jong-pil Park, Young Jo Kim, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2014)
Changes of the kinetics of calcium washout from dog heart after ischaemia
Authors: None BUI-MONG-HUNG, M. APPEL, M. DE MENDONCA
Journal: Cardiovascular Research (1977)

The kinetics of myocardial calcium washout using a calcium free perfusion were studied in controls and animals after a short period of ischaemia. A significantly higher rate for k3 was found after ischaemia. This may represent a greater lability of membrane-bound calcium.
Resistance patterns and outcomes in intensive care unit (ICU)-acquired pneumonia. Validation of European Centre for Disease Prevention and Control (ECDC) and the Centers for Disease Control and Prevention (CDC) classification of multidrug resistant organisms
Authors: Ignacio Martin-Loeches, Antonio Torres, Mariano Rinaudo, Silvia Terraneo, Francesca de Rosa, Paula Ramirez, Emili Diaz, Laia Fernández-Barat, Gian Luigi Li Bassi, Miquel Ferrer
Journal: Journal of Infection (2014)
Gastric Perforation: An Unusual Complication of the Treatment of Oesophageal Atresia
Authors: A. W. Wilkinson
Journal: BMJ (1965)

The importance of starting milk-feeding as soon as possible after major operations on newly born children is now widely appreciated. In babies with oesophageal atresia and tracheo oesophageal fistula after division of the fistula and primary anastomosis, few surgeons have such confidence in the oeso phageal anastomosis that they will permit even the swallowing of water within 48 hours of operation. In order to avoid continuous intravenous therapy and yet achieve a satisfactory intake of water and milk from 24 to 36 hours after operation, some form of feeding by tube is necessary, either through a fine tube passed through the nose and across the oesophageal anastomosis into the stomach at operation or by gastrostomy. For a transoesophageal tube it is usual at this hospital to use translucent polyvinyl chloride tubing (2D Portex), which is soft and limp. More than 400 children have been treated here for oesophageal atresia ; in over 300 a primary anastomosis of the oesophagus has been possible, and in most of these a Portex tube was passed across the anastomosis without complications related to the use of the tubing. This report concerns two children in whom the use of a Stifter type of tubing made of nylon resulted in perforation of the anterior gastric wall by the end of the tubing. In both cases generalized peritonitis resulted and one child died.
Colonic Ischemia after Verapamil Overdose
Authors: Heriberto Gutierrez
Journal: Annals of Internal Medicine (1996)

Letters1 March 1996Colonic Ischemia after Verapamil OverdoseHeriberto Gutierrez, MD and Michael Jorgensen, MDHeriberto Gutierrez, MDKaiser Permanente Medical Center Los Angeles, CA 90027 and Michael Jorgensen, MDKaiser Permanente Medical Center Los Angeles, CA 90027Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-5-199603010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The most frequent manifestations of verapamil overdose are conduction disturbances and hypotension [1], both of which can lead to ischemia. The right colon is susceptible to ischemia because of the variable amount of collateral blood flow present [2]. We report a case of colonic ischemia after verapamil overdose.A 54-year-old woman with a history of bipolar disorder and alcoholism was being treated for hypertension with verapamil (80 mg twice daily). She came to the emergency department intoxicated after taking approximately 20 verapamil tablets as a suicide attempt. Her blood pressure was 73/30 mm Hg, and her pulse ...References1. Hofer CA, Smith JK, Tenholder MF. Verapamil intoxication: a literature review of overdoses and discussion of therapeutic options. Am J Med. 1993; 95:431-38. Google Scholar2. Landreneau RJ, Fry WJ. The right colon as a target organ of nonocclusive mesenteric ischemia. Arch Surg. 1990; 125:591-4. Google Scholar3. Shah AR, Passalacqua BR. Case report. Sustained-release verapamil overdose causing stroke: an unusual complication. Am J Med Sci. 1992; 304:357-9. Google Scholar4. Doughthy JC, Donald AK, Keogh G, Cooke TG. Stercoral perforation with verapamil. Postgrad Med. J. 1994; 70:525. Google Scholar Author, Article, and Disclosure InformationAuthors: Heriberto Gutierrez, MD; Michael Jorgensen, MDAffiliations: Kaiser Permanente Medical Center Los Angeles, CA 90027 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExtensive Bowel Ischaemia after Nifedipine OverdoseWhole Bowel Irrigation and the Hemodynamically Unstable Calcium Channel Blocker Overdose: Primum Non NocereNon-occlusive colonic ischemia induced by verapamil ER overdoseCalcium Channel AntagonistsCalcium Channel Blocker ToxicologyCalcium Channel Blocker Ingestion: An Evidence-Based Consensus Guideline for Out-of-Hospital ManagementPharmacology, Pathophysiology and Management of Calcium Channel Blocker and ??-Blocker ToxicityManagement of Calcium Channel Antagonist OverdoseVerapamil overdose 1 March 1996Volume 124, Issue 5Page: 535KeywordsAbdominal painBlood pressureCecumColonInfarctionIschemiaLaparotomyStrokeSuicideVasopressors ePublished: 15 August 2000 Issue Published: 1 March 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Complexities of face perception and categorisation
Authors: Vicki Bruce, Steve Langton, Harold Hill
Journal: Behavioral and Brain Sciences (1999)

We amplify possible complications to the tidy division between early vision and later categorisation which arise when we consider the perception of human faces. Although a primitive face-detecting system, used for social attention, may indeed be integral to “early vision,” the relationship between this and diverse other uses made of information from faces is far from clear.