tbuckley/cabot-search huggingface dataset:
Preimplantation genetic diagnosis of skin fragility-ectodermal dysplasia syndrome
Authors: H. Fassihi, J. Grace, A. Lashwood, N.V. Whittock, P.R. Braude, S.J. Pickering, J.A. McGrath
Journal: British Journal of Dermatology (2006)

Journal Article Preimplantation genetic diagnosis of skin fragility–ectodermal dysplasia syndrome Get access H. Fassihi, H. Fassihi Genetic Skin Disease Group, St John's Institute of Dermatology, The Guy's, King's College and St Thomas' Hospitals Medical School, St Thomas' Hospital, London SE1 7EH, U.K. *Assisted Conception Unit, Guy's and St Thomas' Hospital NHS Trust, St Thomas Street, London, U.K Search for other works by this author on: Oxford Academic Google Scholar J. Grace, J. Grace Genetic Skin Disease Group, St John's Institute of Dermatology, The Guy's, King's College and St Thomas' Hospitals Medical School, St Thomas' Hospital, London SE1 7EH, U.K. *Assisted Conception Unit, Guy's and St Thomas' Hospital NHS Trust, St Thomas Street, London, U.K Search for other works by this author on: Oxford Academic Google Scholar A. Lashwood, A. Lashwood Genetic Skin Disease Group, St John's Institute of Dermatology, The Guy's, King's College and St Thomas' Hospitals Medical School, St Thomas' Hospital, London SE1 7EH, U.K. *Assisted Conception Unit, Guy's and St Thomas' Hospital NHS Trust, St Thomas Street, London, U.K Search for other works by this author on: Oxford Academic Google Scholar N.V. Whittock, N.V. Whittock Genetic Skin Disease Group, St John's Institute of Dermatology, The Guy's, King's College and St Thomas' Hospitals Medical School, St Thomas' Hospital, London SE1 7EH, U.K. *Assisted Conception Unit, Guy's and St Thomas' Hospital NHS Trust, St Thomas Street, London, U.K Search for other works by this author on: Oxford Academic Google Scholar P.R. Braude, P.R. Braude Genetic Skin Disease Group, St John's Institute of Dermatology, The Guy's, King's College and St Thomas' Hospitals Medical School, St Thomas' Hospital, London SE1 7EH, U.K. *Assisted Conception Unit, Guy's and St Thomas' Hospital NHS Trust, St Thomas Street, London, U.K Search for other works by this author on: Oxford Academic Google Scholar S.J. Pickering, S.J. Pickering Genetic Skin Disease Group, St John's Institute of Dermatology, The Guy's, King's College and St Thomas' Hospitals Medical School, St Thomas' Hospital, London SE1 7EH, U.K. *Assisted Conception Unit, Guy's and St Thomas' Hospital NHS Trust, St Thomas Street, London, U.K Search for other works by this author on: Oxford Academic Google Scholar J.A. McGrath J.A. McGrath Genetic Skin Disease Group, St John's Institute of Dermatology, The Guy's, King's College and St Thomas' Hospitals Medical School, St Thomas' Hospital, London SE1 7EH, U.K. *Assisted Conception Unit, Guy's and St Thomas' Hospital NHS Trust, St Thomas Street, London, U.K John McGrath. E‐mail: john.mcgrath@kcl.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 154, Issue 3, 1 March 2006, Pages 546–550, https://doi.org/10.1111/j.1365-2133.2005.07102.x Published: 01 March 2006 Article history Accepted: 20 September 2005 Published: 01 March 2006
Districts' use of thrombolytic agents.
Authors: C J Burrell, J D Skehan, M L Cowley, C W Barrett, P G Mills
Journal: BMJ (1990)

Illegitimate births 7 2 (registered by one parent) 7 -Mother aged <20 years 67 o 6 / All illegitimate births 5-9 Social classv 5*4 5-; // Illegitimate births 5 2 Xa/ / (registered by both
CHRONIC ALLOGENEIC DISEASE
Authors: Martine Y. K. Armstrong, Ernst Gleichmann, Helga Gleichmann, Lorraine Beldotti, Janine Andre-Schwartz, Robert S. Schwartz
Journal: The Journal of Experimental Medicine (1970)

The incidence of lymphomas in 371 CAF(1) mice injected with BALB/c spleen cells was compared with that in 324 control CAF(1) mice. A high incidence of lymphomas was found in the treated mice, but not in the control animals. The development of the neoplasms was a function of the number of parental cells administered. Analyses of the injected mice for the presence of donor cells indicated that the majority of the injected parental cells lost antihost activity, probably within 24 hr of their administration. The tumors were of host origin, as judged by transplantation tests and antigenic analysis of tumor cells.
EARLY ECHOCARDIOGRAPHIC CHANGES AFTER PERCUTANEOUS IMPLANTATION OF THE EDWARDS SAPIEN TRANSCATHETER HEART VALVE IN THE PULMONARY POSITION
Authors: Shahryar Chowdhury, Girish Shirali, Ziyad Hijazi, Saibal Kar, Raj Makkar, John Rhodes, Michael Mullen, Qi-Ling Cao, Jodi Akin
Journal: Journal of the American College of Cardiology (2012)
The father of cremation
Authors: T. Dalrymple
Journal: BMJ (2010)

In his wonderful memoir of his early life in the Rhondda Valley and in London, Print of a Hare’s Foot , Rhys Davies (1901-78) devotes an entire chapter to Dr William Price of Llantrisant. Dr Price (1800-93) was eccentric, to put it mildly; but he was a real doctor, having qualified in 1821 at Barts in record time. He is said to have cured many where others failed; he operated surgically only as a last resort or (by his own admission) if he needed the money.

Davies’s memoirs lend romance to a time and place that, superficially at least, rather lack it if one just looks at old photographs. Davies was born in relatively privileged circumstances, being the …
Reduction of asthma burden is possible through National Asthma Plans
Authors: M. Kupczyk, T. Haahtela, A. A. Cruz, P. Kuna
Journal: Allergy (2010)

Despite increase in understanding of asthma patomechanisms the practical actions to lessen asthma burden in the communities are far behind of scientific knowledge. There are still reports of uderdiagnosis and poor treatment leading to repeated severe exacerbations, often demanding emergency care and hospitalisation, which cause most of the economic burden both for families and society. From the public health perspective, the key issue is to implement the best standards of care in every-day practice. The problems are different in high income compared to low- and middle-income countries, and the solutions have to be tailored to each country needs and resources. We present here examples from Finland, Poland and Brazil, to show that asthma burden can be reduced using varied strategies in quite different societal, economical and health care environments. The experience from those interventions confirms that regardless of the health care system and its coverage, a major change for the better can be achieved by local efforts, systematic planning and networking to implement the best asthma practice.
Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa
Authors: Nicholas A Feasey, Gordon Dougan, Robert A Kingsley, Robert S Heyderman, Melita A Gordon
Journal: The Lancet (2012)

Invasive strains of non-typhoidal salmonellae have emerged as a prominent cause of bloodstream infection in African adults and children, with an associated case fatality of 20-25%. The clinical presentation of invasive non-typhoidal salmonella disease in Africa is diverse: fever, hepatosplenomegaly, and respiratory symptoms are common, and features of enterocolitis are often absent. The most important risk factors are HIV infection in adults, and malaria, HIV, and malnutrition in children. A distinct genotype of Salmonella enterica var Typhimurium, ST313, has emerged as a new pathogenic clade in sub-Saharan Africa, and might have adapted to cause invasive disease in human beings. Multidrug-resistant ST313 has caused epidemics in several African countries, and has driven the use of expensive antimicrobial drugs in the poorest health services in the world. Studies of systemic cellular and humoral immune responses in adults infected with HIV have revealed key host immune defects contributing to invasive non-typhoidal salmonella disease. This emerging pathogen might therefore have adapted to occupy an ecological and immunological niche provided by HIV, malaria, and malnutrition in Africa. A good understanding of the epidemiology of this neglected disease will open new avenues for development and implementation of vaccine and public health strategies to prevent infections and interrupt transmission.
UK research paper of the year
Authors: Nigel Hawkes
Journal: BMJ (2016)

The UK Research Paper of the Year category recognises outstanding research by one or more UK authors that has potential to considerably improve health and healthcare. Nigel Hawkes describes the shortlisted papers

Do stem cells taken from the bone marrow and injected into patients with heart disease improve heart function? Lots of people believe so, and meta-analyses by the Cochrane Collaboration show a significant positive effect.

But individual trials produce conflicting results, for no very obvious reason. Darrel Francis, professor of cardiology at Imperial College in London, says: “Some things in the early trials didn’t add up and when we went to the journals that published them, we were fobbed off. So we decided to look at discrepancies in all the published trials.” Discrepancies were defined as two or more reported facts that cannot both be true because they are logically or mathematically impossible.

The team’s paper, published in The BMJ, concluded that the more discrepancies a paper contained, the more positive its results. “This field of therapy appears to be most effective in the hands of researchers whose reports contain factual impossibilities,” say Francis and colleague Graham Cole. “Indeed, when the factual impossibilities disappeared, so did any effect of the therapy.”

They expected a sharp reaction from researchers with many discrepancies. “We tried to soften the blow by not naming the hundreds of report authors directly,” Francis says. “But it was authors with few discrepancies, and small or zero effect sizes, who criticised the study most vocally.” This includes the Cardiovascular Cell Therapy Research Network, funded by the US National Institutes of Health with $30 million, whose data coordinator, Lem Moye of the University of Texas, told people to disregard the …
Antibody-dependent antitumor cytotoxicity by human monocytes cultured with recombinant macrophage colony-stimulating factor. Induction of efficient antibody-mediated antitumor cytotoxicity not detected by isotope release assays.
Authors: D H Munn, N K Cheung
Journal: The Journal of Experimental Medicine (1989)

Macrophage colony-stimulating factor (M-CSF) is known to stimulate proliferation of monocyte/macrophage progenitors and enhance in vitro antitumor cytotoxicity by murine macrophages. In this paper we have shown that recombinant human M-CSF causes human peripheral blood monocytes to differentiate in culture into metabolically active macrophage-like cells. These cells mediate very efficient antibody-dependent cellular cytotoxicity (ADCC) against human melanoma and neuroblastoma cell lines in the presence of two murine IgG3 mAbs (3F8 and R24). They also mediate antibody-independent cytotoxicity (or cytostasis) to a lesser extent. Human serum had an inconsistent effect on ADCC, but often induced similar high levels of ADCC. Cytotoxicity was measured using a novel ELISA to detect surviving tumor cells after ADCC. Two conventional isotope-release assays (51Cr and [3H]TdR) underestimated or entirely failed to detect ADCC by M-CSF-activated monocytes. Optimal activation occurred with 100-300 U/ml of M-CSF, and required 9-11 d for completion. Most of the M-CSF cultured monocytes expressed the low-affinity Fc receptor (CD16). ADCC by cells of the monocyte/macrophage lineage using murine IgG3 mAbs may have significance for the immunotherapy of human malignancies.
Effects of infarcted myocardium on regional blood flow measurements to ischemic regions in canine heart.
Authors: R H Murdock, F R Cobb
Journal: Circulation Research (1980)

The present study assesses effects of acutely infarcted myocardium on apparent microsphere loss as a function of time, determines effects of apparent microsphere loss on blood flow measurements to ischemic regions, and determines to what extent apparent microsphere loss alters interpretation of serial measurements of collateral blood flow. Studies were performed in 35 awake mongrel dogs chronically instrumented with catheters in the aorta and left atrium and an occluder on the proximal circumflex coronary artery. Myocardial blood flow was measured before and 15 minutes after complete occlusion. Dogs were randomly divided into four groups to be killed at 6 and 24 hours, and 3 and 6 days. In the 3-day group, an additional blood flow measurement was made 24 hours postocclusion. The entire left ventricle was sectioned into 1- to 2-g samples and myocardial blood flow determined. The ratio of preocclusion blood flow in each ischemic sample to mean nonischemic flow was used to calculate apparent microsphere loss and to correct ischemic blood flow in each sample. Significant apparent microsphere loss occurred in epicardial layers at 24 hours and in epi- and endocardial layers at 3 and 6 days; maximum loss at each interval was 22.3, 19.4, and 22.2% respectively. Absolute blood flow corrections for ischemic myocardium were small, range -0.035 to 0.083 ml/min per g. Changes in flow to ischemic regions between 15 minutes and 24 hours were comparable before and after correction for apparent microsphere loss. Although infarction resulted in significant apparent microsphere loss, effects on ischemic blood flow measurements were very small and consequently did not prevent interpretation of serial blood flow measurements after infarction in animals killed at 3 days.
Use of Diazoxide in Hypertension with Renal Failure
Authors: J. E. F. Pohl, H. Thurston
Journal: BMJ (1971)

Treatment with intravenous and oral diazoxide was given to a group of 39 patients suffering from severe drug-resistant hypertension associated with renal impairment. Rapid initial and good long-term control of hypertension was achieved in all cases without the production of clinically significant postural hypotension. The side effects of diazoxide, including its diabetogenic effect, were easily controlled. There was a highly significant improvement in renal function in most patients on long-term oral diazoxide therapy.Diazoxide may have an important place in both the short- and long-term therapy of resistant hypertension, particularly in association with renal damage.
A bystander cell-based GM-CSF secreting vaccine synergized with a low dose of cyclophosphamide presents therapeutic immune responses against murine hepatocellular carcinoma
Authors: Chen Chen, Jiajie Hou, Zhe Lin, Ming Yao, Runqiu Jiang, Youjing Wang, Yun Gao, Qing Shao, Lei Deng, Yun Chen, Beicheng Sun
Journal: Cellular and Molecular Immunology (2013)
Prosomatostatin-derived antrin is present in gastric D cells and in portal blood.
Authors: M Ravazzola, R Benoit, N Ling, L Orci
Journal: Journal of Clinical Investigation (1989)

The three widely distributed peptides derived from prosomatostatin are the original neurohormone somatostatin-14, somatostatin-28, and somatostatin-28(1-12), which are all derived from the COOH terminus of the precursor. Recently a decapeptide derived from the NH2 terminus of the prohormone has been identified in extracts of rat gastric antrum and named antrin. Data now show that in both rats and humans this new molecular form is concentrated in the D cell of the gastrointestinal mucosa together with somatostatin-28(1-12). The highest concentration of antrin immunofluorescent cells is located in the mucosa of the gastric antrum. Ultrastructural studies performed on pyloric D cells using the protein A-gold technique reveals that antrin is present in the same secretory granules as somatostatin-28(1-12) and detectable in one-third of all secretory granules. Acid extracts of rat hepatic portal plasma contain a peptide similar or identical to antrin, indicating that the antral decapeptide circulates in blood.
British public is sceptical about minimum price on alcohol
Authors: M. Hunter
Journal: BMJ (2011)

<b>Objectives:</b> The purpose of this study was to assess whether MSCTA may be useful for risk stratification of patients with suspected CAD at intermediate pre-test likelihood according to Diamond and Forrester. <b>Design and patients:</b> MSCTA images were evaluated for the presence of significant CAD in 316 included patients (60% male, average age 57±11 years) with suspected CAD and an intermediate pre-test likelihood according to Diamond and Forrester. Patients were followed in time for the occurrence of an event. <b>Main outcome measures:</b> A combined endpoint of all cause mortality, non-fatal infarction, and unstable angina requiring revascularization. <b>Results:</b> Significant CAD was observed in 89 patients (28%), whereas normal MSCTA or non-significant CAD was observed in the remaining 227 (72%) patients. During follow-up (median 621 days (95%-confidence interval: 408-835) an event occurred in 13 patients (4.8%). The annualized event rate was 0.8% in patients with normal MSCT, 2.2% in patients with non-significant CAD and 6.5% in patients with significant CAD. Moreover, MSCTA remained a significant predictor (p&lt;0.05) of events after multivariate correction. <b>Conclusions:</b> Our results suggest that in an intermediate pre-test likelihood population, MSCTA is highly effective in re-stratifying patients into either a low or high post-test risk group. These results further emphasize the usefulness of non-invasive imaging with MSCTA in this patient population.
Delta-24-RGD in Combination With RAD001 Induces Enhanced Anti-glioma Effect via Autophagic Cell Death
Authors: Marta M Alonso, Hong Jiang, Tomohisa Yokoyama, Jing Xu, Nebiyou B Bekele, Frederick F Lang, Seiji Kondo, Candelaria Gomez-Manzano, Juan Fueyo
Journal: Molecular Therapy (2008)

Novel therapies are clearly needed for the treatment of gliomas, and strategies that involve combining oncolytic vectors with chemotherapy hold out significant hope for a more effective treatment of this malignancy. Whether chemotherapy acts directly on tumor cells by inducing cell arrest or cell death, or indirectly by blocking tumor angiogenesis, the resulting delay in tumor growth may provide the oncolytic virus with a wider window of opportunity to overcome the challenge imposed by the growth kinetics of the tumor. In this study we sought to determine whether the oncolytic adenovirus Delta-24-RGD, in combination with everolimus (RAD001), would result in an enhanced anti-glioma effect in vivo. Viability assays showed that Delta-24-RGD antitumoral activity is synergistically enhanced by combination with RAD001. Interestingly, combination treatment of Delta-24-RGD with RAD001 induced autophagy in vitro. We showed that Delta-24-RGD improved survival of tumor-bearing animals in a dose-dependent manner. A significant finding was that RAD001 enhanced the anti-glioma effect of Delta-24-RGD and resulted in the long-term survival of 80% of the experimental animals. Immunostaining of the treated tumors showed upregulation of Atg5, thereby indicating the therapeutic induction of autophagy. This is the first report showing that Delta-24-RGD plus RAD001 causes autophagic cell death, and dramatically increases long-term survival rates of glioma-bearing animals.
Substrate Mapping to Detect Abnormal Atrial Endocardium With Slow Conduction in Patients With Atypical Right Atrial Flutter
Authors: Jin Long Huang, Ching-Tai Tai, Yenn-Jiang Lin, Bien-Hsien Huang, Kun-Tai Lee, Satoshi Higa, Yoga Yuniadi, Yi-Jen Chen, Shih-Lin Chang, Li-Wei Lo, Wanwarang Wongcharoen, Chih-Tai Ting, Shih-Ann Chen
Journal: Journal of the American College of Cardiology (2006)
Bevacizumab and Cancer Treatment-Related Mortality
Authors: Patricia B. Cerrito
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of Socioeconomic Status in Health Research—Reply
Authors: Paula A. Braveman, Catherine Cubbin, Susan Egerter, Kristen S. Marchi
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal