Pro-Parathyroid Hormone
Authors: Joel F. Habener, Byron Kemper
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 July 1972Pro-Parathyroid HormoneJOEL F. HABENER, M.D., BYRON KEMPER, PH.D.JOEL F. HABENER, M.D.Search for more papers by this author, BYRON KEMPER, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-1-151 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with great interest the editorial by Drs. Gordan and Roof, "Humors from Tumors": "Diagnostic Potential of Peptides" (1). Some recent observations from our laboratories seem to be relevant to their comments on the possible molecular characteristics of parathyroid hormone (PTH), secreted ectopically by nonparathyroid neoplasms. They mentioned the possibility, suggested by the work of Berson and Yalow (2), that larger complexes or "primordial big molecules" of peptide hormones may exist and may account for the immunological differences between ectopically secreted hormone and hormone secreted by the endocrine glands.That this may be the case for...References1. GORDANROOF GB: "Humors from tumors": diagnostic potential of peptides. Ann Intern Med 76:501-502, 1972 LinkGoogle Scholar2. BERSONYALOW SR: Heterogeneity of peptide hormones in plasma as revealed by radioimmunoassay. Proceedings of XIe Reunion of French-Speaking Endocrinologists. Paris, Masson et cie, 1971, pp. 105-135 Google Scholar3. KEMPERHABENERPOTTS BJJ: Proparathyroid hormone: identification of a biosynthetic precursor to parathyroid hormone. Proc Nat Acad Sci 69:643-648, 1972 CrossrefMedlineGoogle Scholar4. HABENERKEMPERRICH JBA: Proparathyroid hormone biosynthesis by human parathyroid adenomas. Unpublished Google Scholar5. HAMILTONMACGREGORCHU JRL: Characterization of a new hypercalcemic peptide from parathyroid gland—a possible precursor of parathyroid hormone. Fed Proc 31:225, 1972 Google Scholar6. STEINERCUNNINGHAMSPIGELMAN DDL: Insulin biosynthesis: evidence for a precursor. Science 157:697-700, 1967 CrossrefMedlineGoogle Scholar7. HABENERPOWELLMURRAY JDT: Parathyroid hormone: secretion and metabolism in vivo. Proc Nat Acad Sci USA 68:2986-2992, 1971 CrossrefMedlineGoogle Scholar1. BERSONYALOW SR: Immunochemical heterogeneity of parathyroid hormone in plasma. J Clin Endocrinol Metab 28:1037-1047, 1968 CrossrefMedlineGoogle Scholar2. BERSONYALOW SR: Heterogeneity of peptide hormones in plasma as revealed by radioimmunoassay. Proceedings of XIe Reunion of French-Speaking Endocrinologists. Paris, Masson et Cie, 1971, pp. 105-135 Google Scholar3. POWELLSINGERMURRAY DFT: A new syndrome of hypercalcemia with cancer. Clin Res 20:569, 1972 Google Scholar4. ROOFCARPENTERFINK BBD: Some thoughts on the nature of ectopic parathyroid hormones. Am J Med 50:686-691, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1972Volume 77, Issue 1Page: 151-152KeywordsEndocrine physiologyHormonesParathyroid hormonePeptide hormones Issue Published: 1 July 1972 PDF DownloadLoading ...