tbuckley/cabot-search huggingface dataset:
Prevalence of allergic sensitization to inhalant allergens among blood donors in Kuwait ‐ a desert country
Authors: C. I. Ezeamuzie, M. Al‐Mousawi, H. Dashti, A. Al‐Bashir, M. Al‐Hage, S. Al‐Ali
Journal: Allergy (1997)

Kuwait is a desert country where the prevailing high temperatures, low humidity, and scant vegetation suggest a low prevalence of allergy. We evaluated the prevalence of atopic sensitization (presence of allergen‐specific IgE) among young adult blood donors by screening a total of 505 subjects (male : female ratio 1.6) with mean age of 28.4 years (range 18–50 years). The Pharmacia CAP‐Phadiatop® test, which detects serum IgE specific to most common airborne allergens, was used. Some of the specific sensitizing allergens were also identified by the related CAP‐RAST method. Sensitization was detected in 223 of the 505 subjects (44.2%) screened. Kuwaiti nationals had a significantly higher prevalence rate (50.2%) than non‐Kuwaitis (34.2%) (χ 2 = 8.6, P&lt;0.003). The highest prevalence rate was found among male Kuwaitis (53.8%). The prevalence of current or previous allergic disease (subject‐reported) was 20.6%. Bermuda grass, house‐dust mite ( Dermatophagoides pteronyssinus ), and Chenopodium album were the most prevalent sensitizing allergens, with frequencies of 53.6%, 52.7%, and 50.9%, respectively, among the sensitized subjects (corresponding to 23.7%, 23.3%, and 22.5%, respectively) for the entire population. Sensitization increased with age, but only among the expatriates, younger Kuwaitis being as frequently sensitized as the older ones. Polysensitization was found to be common. Of the 109 CAP‐RAST‐positive subjects, 71 (65.1%) were sensitized to more than one allergen, and 30 of these (42.3%) were sensitized to four or more allergens. These results show that atopy is highly prevalent among young adults in Kuwait, and the higher prevalence rate among nationals than expatriates suggests the involvement of genetic or local environmental factors. The results also confirm that mite and plant pollens may be major sensitizing allergens even in a desert environment.
Electrical and Mechanical Components of Dyssynchrony in Heart Failure Patients With Normal QRS Duration and Left Bundle-Branch Block
Authors: Mark S. Turner, Rob A. Bleasdale, Dragos Vinereanu, Catherine E. Mumford, Vince Paul, Alan G. Fraser, Michael P. Frenneaux
Journal: Circulation (2004)

Resynchronization pacing is an effective symptomatic treatment for heart failure patients with prolongation of the QRS duration (QRSd). Dyssynchronous contraction of the left ventricle is also observed with normal QRSd. We set out to determine how electrical activation of the left ventricular (LV) free wall differed between patients with left bundle-branch block (LBBB) and normal QRSd and if synchrony improved during pacing in patients with normal QRSd.Twenty-two patients were implanted with resynchronization pacemakers, 13 with LBBB (mean QRS, 171 ms) and 9 with normal QRSd <120 ms (mean, 100 ms). LV lead electrograms and surface ECGs in sinus rhythm (unpaced) were recorded. Conventional and tissue Doppler echocardiography were performed without pacing, with LV and biventricular pacing at optimal atrioventricular delay. Lead electrograms from the LV free wall were later in the LBBB patients in absolute terms (155 ms [SD 23] versus 65.5 ms [SD 25]; P=0.05) and also relative to the surface QRS (90.5% [SD 8] versus 65.5% [SD 24]). Improved synchrony of the left and right ventricles (interventricular synchrony) and of the LV myocardial segments (intraventricular synchrony) was observed for patients with LBBB and normal QRSd. Baseline LV synchrony correlated with timing of LV free-wall electrical activation. Improved intraventricular synchrony during pacing also correlated with LV free-wall electrical activation time.Resynchronization of systole can be achieved for patients with normal QRSd and LBBB during biventricular and LV pacing. The timing of LV free-wall electrical activation correlated with the improvement in synchrony.
Disappearance of Iron-Deficiency Anemia in a High-Risk Infant Population Given Supplemental Iron
Authors: Pablo Vazquez-Seoane, Robert Windom, Howard A. Pearson
Journal: New England Journal of Medicine (1985)

Iron deficiency is the most common single nutrient deficiency in the world. Studies in the United States have shown that the prevalence of overt iron-deficiency anemia is 5 to 15 per cent in American infants and children 9 to 36 months old.1 2 3 Although iron-deficiency anemia is most prevalent among the poor, owing to feeding practices and dietary inadequacy of foods rich in iron, which tend to be expensive, it cuts across socioeconomic barriers. It is particularly frequent during the second year of life because of exhaustion of transplacental iron reserves, rapid growth, and consumption of large amounts of iron-poor milk. . . .
Scintigraphic Detection of Bleeding After Transfemoral Arteriography, Using Technetium-99m Labeled RBCs
Authors: S GIPS, O ISRAEL
Journal: Clinical Nuclear Medicine (1986)

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssuePrevious IssuesPublished Online First Collections ACNM MeetingsCMECommunication in OrganizationCOVID-19Feedback and RewardsFrom the American College of Nuclear MedicineHighly Cited and Frequently Read ArticlesPlanning and Conducting Meetings EffectivelyQuality and Safety in Health CareRecruitment of New PhysiciansTips for Giving a Memorable PresentationTips for LeadersTips for Physicians in Getting the Right Job ACNM ArticlesACNM Website For Authors Submit a ManuscriptInformation for AuthorsLanguage Editing ServicesAuthor Permissions Journal Info About the JournalEditorial BoardAdvertisingOpen AccessSubscription ServicesReprintsRights and Permissions All Articles Images Videos Podcasts Blogs Advanced Search
Nutritional Deficiency and AIDS
Authors: Gregg Coodley
Journal: Annals of Internal Medicine (1990)

Letters15 November 1990Nutritional Deficiency and AIDSGregg Coodley, MDGregg Coodley, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-10-807_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Barry S. Kendler's letter (Ann Intern Med. 1990;113:409-10) suggests that nutritional deficiency, including vitamin deficiency, may play a role in the progression of human immunodeficiency virus (HIV) infection.The role of vitamin or nutritional deficiency in affecting the progression of HIV infection is not well established. There are tantalizing clues that low levels of zinc, for example, may serve as a marker for progression of HIV infection (1). Another intriguing study suggested that B6replacement, in cases of clear deficiency, may raise CD4 counts (2). However, data on the relation between deficiency and disease are still relatively...References1. SorensenGrahamOdaka DNN. Serum copper and zinc levels predict progression to AIDS independently of CD4 level [Abstract Th.C. 677]. Sixth International Conference on AIDS, San Francisco, California, June 21-24, 1990. Google Scholar2. Monatero-AtrenzaBaumBeach EMR. Vitamin B6 and immune function in HIV infection [Abstract 3123]. Sixth International Conference on AIDS, San Francisco, California, June 21-24, 1990. Google Scholar3. BeachMantero-AtrenzaVan Riel REF. Nutritional deficiencies in early HIV infection: I: Plasma vitamin levels [Abstract TH. B. U. 40]. Fifth International Conference on AIDS, Montreal, Canada, June 4-9, 1989. World Health Organization. Google Scholar4. MalcolmTynanSutherland JPD. Trace metal and vitamin deficiencies in AIDS [Abstract Th. B. 206]. Sixth International Conference on AIDS, San Francisco, California, 21-24, June 1990. Google Scholar5. BogdenBakerFrank JHO. Micronutrient status and HIV infection. Ann N Y Acad Sci. 1990;587:189-95. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Oregon Health Sciences University Portland, OR 97201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHIV Infection-Related Cachexia and LipodystrophyNutrition and HIV/AIDS in sub-Saharan Africa: An overviewTreatment of AIDS Anorexia-Cachexia Syndrome and Lipodystrophy 15 November 1990Volume 113, Issue 10Page: 807-807KeywordsAIDSHIVHIV infectionsMalnutritionZinc Issue Published: 15 November 1990 PDF DownloadLoading ...
Transgastric Perforation of a PEG and Successful Endoscopic Management of the Complication using the Fibrin Sealing Technique
Authors: M. G. Willems
Journal: Endoscopy (1990)

See also: Transgastric Perforation of a Percutaneous Endoscopic Feeding Tube with a Fatal OutcomeEndoscopy 1989; 21(01): 45-46DOI: 10.1055/s-2007-1012895
Influence of saddle type upon the incidence of lower back pain in equestrian riders.
Authors: S Quinn, S Bird
Journal: British Journal of Sports Medicine (1996)

To investigate the possible influences of saddle type on the incidence of "lower back pain" in a cross section of equestrian riders.108 equestrian riders completed a questionnaire concerning their riding habits and whether they suffered from lower back pain. In particular they were asked whether they used a traditional style/general purpose saddle (GP) or a deep seated/Western style saddle (W).48% of the riders reported suffering from lower back pain, the incidence being higher in the GP saddle users (66%) than in W saddle users (23%) (P < 0.001). Female riders had a higher incidence of lower back pain than males, 58% v 27% (P < 0.005). When the genders were analysed separately for the effect of saddle type, males using the GP and W saddles had a 33% and 6% incidence of lower back pain respectively, while females using the GP and W saddles had a 72% and 33% incidence. The highest incidence of lower back pain occurred in the GP saddle users who had been riding for more than 15 years (P < 0.07). The data also indicated a possible tendency for there to be more low back pain among riders using a short stirrup length. No other factors were found to affect the incidence of lower back pain.The difference in the incidence of lower back pain between the users of the two saddle types may be due to the additional comfort, cushioning, postural positioning, and stability offered by the design of the deep seated saddle. The results suggest that, while a deep seated saddle is not suited to all equestrian activities, where possible its use should be considered because of its effect in reducing the risk of lower back pain.
Paediatrician found guilty of misconduct
Authors: C. Court
Journal: BMJ (1994)

A hospital paediatrician in Britain who gave excessive doses of drugs, including sedatives, to at least 12 babies has been found guilty of serious professional misconduct. A hearing of the General Medical Council's professional conduct committee directed Dr Joyce Inyang not to practise for a year except in an NHS hospital under close supervision. The committee also ordered Dr Inyang to undergo a structured programme …
A randomised controlled trial on pegylated interferon alfa-2a (40kd) (Pegasys) or IFN alfa-2a (ROFERON-A) plus ribavrin (RBV) and amantadine (AMA) vs IFN alfa-2a and RBV in naïve patients with chronic HCV
Authors: A. Mangia, G.L. Ricci, N. Minerva, M. Persico, V. Carretta, D. Bacca, M. Cela, M. Piattelli, D. di Festi, M. Annese, V. Guadagnino, F. Spirito, A. Andriulli
Journal: Journal of Hepatology (2003)
Reverse breeding in Arabidopsis thaliana generates homozygous parental lines from a heterozygous plant
Authors: Erik Wijnker, Kees van Dun, C Bastiaan de Snoo, Cilia L C Lelivelt, Joost J B Keurentjes, Nazatul Shima Naharudin, Maruthachalam Ravi, Simon W L Chan, Hans de Jong, Rob Dirks
Journal: Nature Genetics (2012)
A clinical evaluation of ano-rectal pressure studies in the diagnosis of Hirschsprung's disease
Authors: I. Aaronson, H. H. Nixon
Journal: Gut (1972)

Stimulation of the rectum by stretch results, in the normally innervated bowel, in the reflex relaxation of the internal anal sphincter. The absence of this rectosphincteric reflex in Hirschsprung's disease forms the basis of a simple and safe diagnostic test. Our experience over two years using a simplified air-filled pressure probe system is described, based on the examination of 267 infants and children with abnormal bowel function, of whom 114 were suffering from Hirschsprung's disease.A review of the last 100 consecutive patients examined shows an overall diagnostic reliability of 85%. This was of the same order as that of a barium enema in these patients, and indeed of obtaining the correct diagnosis on the first rectal biopsy. It has proved easier to exclude the disease (90.8%) than to confirm its presence (74.3%), and has been found to be more reliable than the barium enema in the diagnosis of ultrashort segment disease. The commoner pitfalls in the interpretation of the trace are described. We consider that this investigation justifies a place in the routine investigation of Hirschsprung's disease alongside the barium enema and rectal biopsy, and is of particular value as a simple screening test in outpatients.
The course of hepatitis C virus infection after liver transplantation
Authors: Cyrille Féray, Michelle Gigou, Didier Samuel, Valérie Paradis, Judith Wilber, Marie France David, Mickey Urdea, Michel Reynes, Christian Bréchot, Henri Bismuth
Journal: Hepatology (1994)

Hepatitis C virus—induced liver disease is becoming a main indication for liver transplantation. Recurrence of hepatitis after transplantation has been reported, but its long–term consequences are unknown. Seventynine patients positive for hepatitis C virus (group 1) and 106 subjects negative for hepatitis C virus antibody (group 2) with a mean follow–up of 4 yr were retrospectively studied by means of serology, nested polymerase chain reaction and branched–DNA technology before and after liver transplantation. The actuarial rates of hepatitis C virus—related acute hepatitis were 72% and 20% at 4 yr in groups 1 and 2, respectively. Progression to chronic active hepatitis occurred in 61% and 36% of the subjects within 3 yr of the onset of recurrent and acquired hepatitis, respectively. No case of acute graft failure and two cases of cirrhosis were related to recurrent or acquired hepatitis C virus liver disease. Hepatitis C virus RNA levels were significantly increased in cases of hepatitis after transplantation. In contrast, the pretransplant hepatitis C virus RNA level was not predictive of recurrence. Our results establish the general persistence of hepatitis C virus infection after liver transplantation, the frequency and the severe course of recurrent liver disease. However, liver transplantation in hepatitis C virus antibody—positive patients still has a good medium–term prognosis. (Hepatology 1994;20:1137-1143).
Unconscious influences<i>of</i>, not just<i>on</i>, decision making
Authors: Géraldine Coppin
Journal: Behavioral and Brain Sciences (2014)

Abstract This commentary focuses on the bidirectional links between unconscious influences and decision making. In particular, it examines the extent to which awareness is (not) necessary to the impact of decisions on psychological processes such as preferences. This analysis might help researchers to gain an extended perspective of Newell &amp; Shanks' (N&amp;S's) concerns regarding the role of unconscious influences in theories of decision making.
Impact of Blood Pressure and Antihypertensive Treatment on Incipient and Overt Nephropathy, Retinopathy, and Endothelial Permeability in Diabetes Mellitus
Authors: Hans-Henrik Parving
Journal: Diabetes Care (1991)

Diabetic nephropathy is the main cause of the increased morbidity and mortality in insulin-dependent diabetes mellitus (IDDM) patients. Elevated blood pressure accelerates and effective blood pressure reduction with β-blockers and/or angiotensin-converting enzyme (ACE) inhibitors delays the progression of nephropathy and reduces albuminuria. All previous reports dealing with the natural history of diabetic nephropathy demonstrated a cumulative death rate between 50 and 77% 10 yr after onset of nephropathy. Effective antihypertensive treatment reduced the cumulative death rate to 15–20% 10 yr after onset of nephropathy. Recent randomized control studies indicate that ACE inhibition may delay and even prevent the development of diabetic nephropathy in normotensive IDDM patients with persistent microalbuminuria. Several cross-sectional and prospective studies suggest an association between elevated blood pressure and the development and progression of diabetic retinopathy. Furthermore, carotid insufficiency or other causes of unilaterally or bilaterally reduced retinal blood flow (pressure) diminish the development of diabetic retinopathy. Diabetic retinopathy is characterized by abnormal leakage of fluorescein through the blood-retinal barrier, an abnormality that can be reversed during antihypertensive treatment. It is well documented that elevated blood pressure, poor metabolic control, and diabetic microangiopathy independently enhance the endothelial leakage of plasma proteins in diabetes mellitus. A link between capillary hypertension, increased extravasation of plasma proteins, and the development and progression of diabetic microangiopathy has been suggested. Blood pressure reduction diminishes the extravasation of plasma proteins. The above results strongly support the case for early and effective treatment of arterial blood pressure elevation in diabetes.
Inhibition of Restenosis in Femoropopliteal Arteries
Authors: Michael Werk, Soenke Langner, Bianka Reinkensmeier, Hans-Frank Boettcher, Gunnar Tepe, Ulrich Dietz, Norbert Hosten, Bernd Hamm, Ulrich Speck, Jens Ricke
Journal: Circulation (2008)

The success of percutaneous intervention in peripheral arterial disease is limited by restenosis. The aim of the present pilot study was to evaluate a novel method of local drug delivery.This randomized multicenter study with blinded reading enrolled 87 patients in Rutherford class 1 to 4 with occlusion or hemodynamically relevant stenosis, restenosis, or in-stent restenosis of femoropopliteal arteries. Treatment was performed by either conventional uncoated or paclitaxel-coated balloon catheters. The primary end point was late lumen loss at 6 months. Secondary end points included restenosis rate, ankle brachial index, Rutherford class, target lesion revascularization, and tolerance up to >18 months. Before intervention, there were no significant differences in lesion characteristics such as reference diameter (5.3+/-1.1 versus 5.2+/-1.0 mm), degree of stenosis (84+/-11% versus 84+/-16%), proportion of restenotic lesions (36% versus 33%), and mean lesion length (5.7 cm [0.8 to 22.6 cm] versus 6.1 cm [0.9 to 19.3 cm]) between treatment groups. The 6-month follow-up angiography performed in 31 of 45 and 34 of 42 patients showed less late lumen loss in the coated balloon group (0.5+/-1.1 versus 1.0+/-1.1 mm; P=0.031). The number of target lesion revascularizations was lower in the paclitaxel-coated balloon group than in control subjects (3 of 45 versus 14 of 42 patients; P=0.002). Improvement in Rutherford class was greater in the coated balloon group (P=0.045), whereas the improvement in ankle brachial index was not different. The difference in target lesion revascularizations between treatment groups was maintained up to >18 months. No adverse events were assessed as related to balloon coating.In this pilot trial, paclitaxel balloon coating caused no obvious adverse events and reduced restenosis in patients undergoing angioplasty of femoropopliteal arteries.
Induction of granulocyte-macrophage colony-stimulating factor (GM-CSF) by a novel cytokine, IL-17F (ML-1), in bronchial epithelial cells*1
Authors: M. Kawaguchi, F. Kokubu, M. Odaka, S. Suzuki, S. Watanabe, K. Ieki, S. Matsukura, M. Kurokawa, M. Adachi, S. Huang
Journal: Journal of Allergy and Clinical Immunology (2004)
A Novel C-terminal Nonsense Mutation, Q315X, of the Aryl Hydrocarbon Receptor-Interacting Protein Gene in a Japanese Familial Isolated Pituitary Adenoma Family
Authors: Takeo Iwata, Shozo Yamada, Junko Ito, Naoko Inoshita, Noriko Mizusawa, Shinji Ono, Katsuhiko Yoshimoto
Journal: Endocrine Pathology (2014)
Universal repression from consciousness versus abnormal dissociation from self-consciousness
Authors: Robert G. Kunzendorf
Journal: Behavioral and Brain Sciences (2006)

Freud attributed uncovered incest, initially, to real abuse dissociated from self-consciousness , and later, to wishes repressed from consciousness . Dissociation is preferred on theoretical and empirical grounds. Whereas dissociation emerges from double-aspect materialism, repression implicates Cartesian dualism. Several studies suggest that abnormal individuals dissociate trauma from self-conscious source-monitoring, thereby convincing themselves that the trauma is imaginary rather than real, and re-experience the trauma as an unbidden image.
Ranitidine and oxygen derived free radical scavengers in haemorrhagic shock induced gastric lesions.
Authors: E C Tsimoyiannis, C J Sarros, J C Tsimoyiannis, K Moutesidou, G Akalestos, O B Kotoulas
Journal: Gut (1988)

The role of oxygen derived free radicals in gastric lesions induced by haemorrhagic shock and the protective effect of oxygen radical scavengers, allopurinol and ranitidine, were investigated. Forty five rabbits underwent haemorrhagic shock for 30 minutes and reinfusion of shed blood. They were killed 30 minutes later. The animals were divided in five groups: A (n = 10): Control, B (n = 10): intravenous ranitidine pretreatment, C (n = 10): oral allopurinol, 24 and 2 h before surgery; D (n = 10): intravenous pretreatment with superoxide Dismutase plus catalase, E (n = 5): 60 minute haemorrhagic shock without reinfusion and treatment. Erosions and/or petechiae in all animals in Group A were observed. Three animals in group B and C and 2 in group D (p less than 0.005, p less than 0.001) had gastric lesions. The lesions in the pretreatment groups were significantly smaller than in controls. Oxygen radicals plus HCl play an important role in shock induced gastric lesions. Oxygen radical antagonists show a significant protective role.
Germline Mutations of the p53 Tumor-Suppressor Gene in Children and Young Adults with Second Malignant Neoplasms
Authors: David Malkin, Kent W. Jolly, Noële Barbier, A. Thomas Look, Stephen H. Friend, Mark C. Gebhardt, Tone I. Andersen, Anne-Lise Børresen, Frederick P. Li, Judy Garber, Louise C. Strong
Journal: New England Journal of Medicine (1992)

Acquired mutations in the p53 tumor-suppressor gene have been detected in several human cancers, including colon, breast, and lung cancer. Inherited mutations (transmitted through the germline) of this gene can underlie the Li—Fraumeni syndrome, a rare familial association of breast cancer in young women, childhood sarcomas, and other malignant neoplasms. We investigated the possibility that p53 mutations in the germline are associated with second primary cancers that arise in children and young adults who would not be considered as belonging to Li—Fraumeni families.