Islet-cell Carcinoma Treated with Alloxan
Authors: FREDERICK E. ZIMMER
Journal: Annals of Internal Medicine (1964)

Case Studies1 September 1964Islet-cell Carcinoma Treated with AlloxanAssociated with Calcified Hepatic Metastases and Thyrotoxic MyopathyFREDERICK E. ZIMMER, M.D., F.A.C.P.FREDERICK E. ZIMMER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-3-543 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe syndrome of organic hypoglycemia is sufficiently infrequent in its occurrence, varied in etiology, arresting in its manifestations, and at times dramatic in response to treatment as to have received considerable attention in the medical press. The case reported here is believed to be worthy of presentation because of its unusual features.CASE REPORTMrs. A. T. (G.M.C. #292-784) was referred to the Geisinger Medical Center on January 11, 1961, for investigation of known hypoglycemia. A 46-year-old housewife and factory worker, she had first noted a tendency to gain weight about 5 years prior to admission. During that interval she...References1. CRAINTHORN ELGW: Functioning pancreatic islet-cell adenomas; review of literature and presentation of 2 new differential tests. Medicine (Baltimore) 28: 427, 1949. CrossrefMedlineGoogle Scholar2. HOWARDMOSSRHOADS JMNHJE: Hyperinsulinism and islet-cell tumors of the pancreas; with 398 recorded tumors. Int. Abstr. Surg. 90: 417, 1950. MedlineGoogle Scholar3. ROGERS FA: Islet-cell tumors of the pancreas and hyperinsulinism. Amer. J. Surg. 99: 268, 1960. CrossrefMedlineGoogle Scholar4. HANSON JS: Hypoglycemia associated with pancreatic islet-cell tumors. Review of the literature and case report of a malignant tumor. Amer. J. Med. 28: 468, 1960. CrossrefMedlineGoogle Scholar5. SCHINZBAENSCHFRIEDLUEHLINGER HRWEEE: Roentgen Diagnostics Vol. IV, edited by CASE, J. T., Grune and Stratton, New York, 1954, p. 3672. Google Scholar6. SHANKSKERLEY SCP: A Textbook of X-ray Diagnosis, Vol. III, Third Edition, W. B. Saunders, Philadelphia, 1958, p. 513. Google Scholar7. ASTLEYHARRISON RN: Miliary calcification of liver; report of case. Brit. J. Radiol. 22: 723, 1949. CrossrefMedlineGoogle Scholar8. HEILBRUNKLEIN NAJ: Massive calcification of liver; case report with discussion of its etiology on basis of alveolar hydatid disease. Amer. J. Roentgen. 55: 189, 1946. Google Scholar9. ASPRAY M: Calcified hemangiomas of liver. Amer. J. Roentgen. 53: 446, 1945. Google Scholar10. FRIEDLANDER EO: Hyperinsulinism secondary to disease of the pancreas and organs adjacent to the pancreas: a review of the world literature. Ann. Intern. Med. 52: 838, 1960. LinkGoogle Scholar11. HERRMANNGIUS SFJA: Hyperinsulinism associated with calcified tumor of pancreas, with surgical cure. JAMA 108: 1402, 1937. CrossrefGoogle Scholar12. BRUNSCHWIGALLENOWENSTHORNTON AJGFMTF: Alloxan in treatment of insulin-producing islet cell carcinoma of pancreas. JAMA 124: 212, 1944. CrossrefGoogle Scholar13. CONNHINERMAN JWDL: Effects of alloxan upon function and structure of normal and neoplastic pancreatic islet cells in man. Amer. J. Path. 24: 429, 1948. MedlineGoogle Scholar14. CONNHINERMANBUXTON JWDLRW: Effects of alloxan upon human pancreas. J. Lab. Clin. Med. 32: 347, 1947. MedlineGoogle Scholar15. FLINNMINNICKGAY LBEDM: Alloxan in treatment of a case of islet-cell carcinoma of pancreas with liver metastases. Ann. Intern. Med. 26: 936, 1947. LinkGoogle Scholar16. FISHERGIUSJANES JJARG: Islet-cell tumor of pancreas with hyperinsulinism; failure of surgical and alloxan treatment; report of a case. Arch. Path. (Chicago) 60: 628, 1955. MedlineGoogle Scholar17. CLEEMPOELCONRADBASTENIE HVPA: Carcinoma of islets of Langerhans; test for hyperinsulism. Lancet 269: 801, 1955. CrossrefMedlineGoogle Scholar18. MCINTOSHROBERTSONWALTERSRANDALL HWHRWRV: Functioning islet-cell carcinoma of the pancreas with metastases and prolonged survival. Arch. Surg. (Chicago) 80: 1021, 1960. CrossrefGoogle Scholar19. LANDAULEVINEHERTZ BRHJR: Prolonged glucagon administration in a case of hyperinsulinism due to disseminated islet-cell carcinoma. New Eng. J. Med. 259: 286, 1958. CrossrefMedlineGoogle Scholar20. BROWNHARGREAVESTYLER HHPFH: Islet-cell adenoma of pancreas; metabolic studies on patient treated with corticotropin and cortisone. Arch. Intern. Med. (Chicago) 89: 951, 1952. CrossrefGoogle Scholar21. MASON AS: Functioning malignant islet-cell tumor of pancreas. Primary growth removed, metastases in liver seen. Recurrence of hyperinsulinism, treated with cortisone. Proc. Roy. Soc. Med. 46: 305, 1953. CrossrefMedlineGoogle Scholar22. BAUMGARTNERREYNOLDS CJJL: Functioning metastases from Islet-cell tumor of pancreas; control with corticotropin (ACTH). Arch. Surg. (Chicago) 70: 793, 1955. CrossrefGoogle Scholar23. LUKENS FD: Alloxan diabetes. Physiol. Rev. 28: 304, 1948. CrossrefMedlineGoogle Scholar24. GILCHRISTLYNCH WSMJ: Organic hyperinsulinism treated with alloxan. Lancet 260: 440, 1951. CrossrefGoogle Scholar25. GURLINGBARONSMITH KJDNEJ: Thyroid adenomas and thyrotoxicosis in patients with hypopituitarism following hypophysectomy. J. Clin. Endocr. 19: 717, 1959. CrossrefGoogle Scholar26. ADAMSDENNY-BROWNPEARSON RDDCM: Diseases of Muscle, Second Edition, Harper & Bros., New York, 1962, pp. 594-602. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FREDERICK E. ZIMMER, M.D., F.A.C.P.Affiliations: Danville, PennsylvaniaFrom the Department of Internal Medicine, Geisinger Medical Center, Danville, Pennsylvania.Requests for reprints should be addressed to Frederick E. Zimmer, M.D., Department of Internal Medicine, Geisinger Medical Center, Danville, Pa. 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CARTERDEXTRANChemotherapeutic management of the hormone-secreting endocrine malignanciesNotes on streptozotocin in metastatic insulinomaDer experimentelle chemische DiabetesTreatment of Gastrointestinal Cancer: Current Status and Recent ProgressThe Study of Carbohydrate Metabolism 1 September 1964Volume 61, Issue 3Page: 543-549KeywordsEtiologyHypoglycemiaHypoglycemicsInsulinPancreasWeight gain ePublished: 1 December 2008 Issue Published: 1 September 1964 PDF downloadLoading ...