tbuckley/cabot-search huggingface dataset:
Technetium-99m DISIDA Imaging in Autosomal-Dominant Polycystic Kidney
Authors: JONATHAN MISHKIN, P TODD MAKLER, MICHAEL G. VELCHIK, KEVIN McCARTHY
Journal: Clinical Nuclear Medicine (1986)

Tc-99m DISIDA imaging was performed in a patient with a known autosomal-dominant polycystic kidney. Multiple photopenic regions were visualized within the liver in the early phase of the study. CT revealed multiple cystic masses within the liver, confirming the diffuse hepatic disease related to the patient's underlying disease. This abnormal tracer distribution should be included in the list of the masses seen on the Tc-99m DISIDA image.
Diagnostic Value of Quantitative Sacroiliac Joint Scintigraphy in Brucellosis
Authors: MAHMOUD I. EL-DESOUKI, R. SUKUMAR BENJAMIN
Journal: Clinical Nuclear Medicine (1999)

Increased bone activity in the sacroiliac joints has been shown to be a sensitive method for detecting sacroiliitis in brucellosis. Because symmetrically increased uptake usually is difficult to detect, this study was performed to improve the sensitivity by quantifying sacroiliac joint uptake. Quantification was accomplished by normalizing sacroiliac joint activity to activity in the lumbar spine and sacrum. From rectangular regions of interest over a standardized posterior pelvic view, the ratios of the sacroiliac:lumbar spine and sacroiliac:sacrum were calculated. Abnormal sacroiliac joint uptake was defined as uptake greater than the mean +2 SD of normal. This was applied to 79 patients with brucella sacroiliitis. The quantitative approach was compared with visual interpretation. Of the 16 patients in the age group of 5 to 19 years, 7 patients had visual evidence of sacroiliitis and 9 patients had positive evidence by sacroiliac-sacrum and 12 by sacroiliac-lumbar spine quantification. Of 21 patients who were 20 to 30 years old, 10 patients had positive visual evidence, whereas 17 and 20 patients had positive evidence of sacroiliitis by sacroiliac-sacrum and sacroiliac-lumbar spine, respectively. Of 42 patients who were 31 to 85 years old, 24, 32, and 36 patients had positive evidence of sacroiliitis by visual inspection, sacroiliac-sacrum, and sacroiliac-lumbar spine, respectively. Thus, the quantitative approach increased the sensitivity in diagnosing Brucella sacroiliitis in all age groups by 31.3%, 47.6%, and 28.6%, respectively, for sacroiliac-lumbar spine and by 12.5%, 33.3%, and 19%, respectively, for sacroiliac-sacrum.
Assessing the Measurement Precision of Various Arsenic Forms and Arsenic Exposure in the National Human Exposure Assessment Survey (NHEXAS)
Authors: Edo D. Pellizzari, C. Andrew Clayton
Journal: Environmental Health Perspectives (2005)

Archived samples collected from 1995 to 1997 in the National Human Exposure Assessment Survey (NHEXAS) in U.S. Environmental Protection Agency Region 5 (R5) and the Children's Study (CS) in Minnesota were analyzed for total arsenic, arsenate [As(V)], arsenite, dimethyl arsenic acid (DMA), monomethyl arsenic acid (MMA), arsenobetaine (AsB), and arsenocholine. Samples for the CS included drinking water, urine, hair, and dust; both studies included food (duplicate plate, composited 4-day food samples from participants). Except for AsB and As(V), the levels for As species measured in the food and drinking water samples were very low or nonexistent. The analytical methods used for measuring As species were sensitive to < 1 ppb. During the analysis of food and drinking water samples, chromatographic peaks appeared that contained As, but they did not correspond to those being quantified. Thus, in some samples, the sum of the individual As species levels was less than the total As level measured because the unknown forms of As were not quantified. On the other hand, total As was detectable in almost all samples (> 90%) except for hair (47%), indicating that the analytical method was sufficiently sensitive. Population distributions of As concentrations measured in drinking water, food (duplicate plate), dust, urine, and hair were estimated. Exposures to total As in food for children in the CS were about twice as high as in the general R5 population (medians of 17.5 ppb and 7.72 ppb, respectively). In addition, AsB was the most frequently detected form of As in food eaten by the participants, while As(V) was only rarely detected. Thus, the predominant dietary exposure was from an organic form of As. The major form of As in drinking water was As(V). Spearman (rank) correlations and Pearson (log-concentration scale) correlations between the biomarkers (urine, hair) and the other measures (food, drinking water, dust) and urine versus hair were performed. In the NHEXAS CS, total As and AsB in the food eaten were significantly correlated with their levels in urine. Also, levels of As(V) in drinking water correlated with DMA and MMA in urine. Arsenic levels in dust did not show a relationship with urine or hair levels, and no relationship was observed for food, drinking water, and dust with hair. Urine samples were collected on days 3, 5, and 7 of participants' monitoring periods. Total As levels in urine were significantly associated across the three pairwise combinations--i.e., day 3 versus day 5, day 3 versus day 7, and day 5 versus day 7. Because the half-life of As in the body is approximately 3 days, this suggests that some exposure occurred continually from day to day. This trend was also observed for AsB, suggesting that food is primarily responsible for the continual exposure. DMA and MMA in urine were also significantly correlated but not in all combinations.
RECURRING ECZEMA OF EXPOSED PARTS; HEAT ECZEMA, COLD ECZEMA
Authors: WILFRID B. WARDE
Journal: British Journal of Dermatology (1903)

Journal Article RECURRING ECZEMA OF EXPOSED PARTS; HEAT ECZEMA, COLD ECZEMA Get access WILFRID B. WARDE, M.D., M.R.C.P. WILFRID B. WARDE, M.D., M.R.C.P. Assistant Physician to the Blackfriars Hospital for Diseases of the Skin Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 15, Issue 10, 1 October 1903, Pages 349–365, https://doi.org/10.1111/j.1365-2133.1903.tb16468.x Published: 01 October 1903
The Removal of Central Venous Silicone Rubber Catheters
Authors: Robert Chase
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Complications associated with the use of indwelling right atrial catheters include infection, thrombosis, dislodgement, migration of the catheter tip, subcutaneous catheter leak, and erosion of the Dacron cuff.<sup>1-6</sup>We report retention of a catheter fragment followed by recurrent bacteremia. <h3>Report of a Case.—</h3> A 56-year-old woman with a history of recurrent urinary tract infections was treated with a six-week course of ampicillin through a Hickman catheter for an<i>Escherichia coli</i>vertebral osteomyelitis. After an additional sevenday regimen of cefamandole for a urinary tract infection caused by<i>Klebsiella pneumoniae</i>, the catheter was removed. One month later, the patient experienced<i>K pneumoniae</i>sepsis (urine culture showed growth of only<i>Candida tropicalis</i>) for which she was treated with two weeks of cefotaxime via a second Hickman catheter. She was then transferred to a rehabilitation facility. Five weeks later, the patient again experienced<i>K pneumoniae</i>sepsis, which responded to cefotaxime.
Experiences with "rapid appraisal" in primary care: involving the public in assessing health needs, orientating staff, and educating medical students
Authors: S. A Murray
Journal: BMJ (1999)

The incorporation of lay perspectives in research and development in the health service is not only politically mandated in recent white and green papers but also has the potential to improve the relevance and impact of research and the quality of subsequent services.1 There are many ways of identifying lay views and incorporating these into decisions, but the methods used to achieve this need further evaluation. Traditional methods to encourage public participation—such as public meetings, patient participation groups, and complaints procedures—have met with limited success.2 During the past decade the technique named "rapid appraisal" has begun to make important contributions in the assessment of local needs and planning in the developed and developing countries (see box on p441). Its use in the United Kingdom has been guided by the work of Chambers,3 Annett and Rifkin,4 and Ong,5 and Manderson and Aaby have described an "epidemic increase" in the use of this method.6 Rapid appraisal has now been used by community workers and primary healthcare teams to gain public involvement in the assessment of needs from the Isle of Skye to inner city London and from Belfast to Norway. Initially used for assessment of global needs it has also been used with specific groups of patients and to gain broad perspectives on accident and emergency services.7 #### Summary points
Can Parkinson’s disease be cured by stimulating neurogenesis?
Authors: Thomas Foltynie
Journal: Journal of Clinical Investigation (2015)

There have been many attempts at slowing down or even reversing the neurodegenerative process of Parkinson's disease (PD). To date, there are no treatments of proven value in this regard. One underexplored route to slow the neurodegenerative process is the use of agents that may stimulate neurogenesis in the subventricular zone. In animal models of PD, PDGF-BB has been shown to restore/protect against dopaminergic deficits caused by neurotoxins via increased neurogenesis in the subventricular zone. Previous work suggests that these new cells are not themselves dopaminergic but have trophic effects on residual dopaminergic cells in the substantia nigra. In this issue of the JCI, Paul et al. evaluate this agent in individuals with PD and show that i.c.v. administration of PDGF-BB is safe and well tolerated. This study lays the foundation for formal dose-finding studies and clinical trials to assess the efficacy of this agent as a potential neuroprotective treatment for PD.
Incidence and immunochemical features of serum cryoglobulin in chronic liver disease.
Authors: G P Jori, G Buonanno, F D'onofrio, A Tirelli, F Gonnella, S Gentile
Journal: Gut (1977)

Essential cryoglobulinaemia was detected in 44 out of 150 patients (29%) screened on the basis of histological confirmation of chronic inflammatory liver disease (chronic persistent or aggressive hepatitis, or cirrhosis). Cryoglobulinemia prevailed in the patients whose hepatic tissue showed more features of active inflammation; also, a female prevalence was observed. There were no correlations between cryoglobulinaemia and either HBsAg positivity or alcoholic liver disease. Mixed cryoglobulins made of heterogeneous immunoglobulins without monotypic components were mostly associated with established cirrhosis, whereas monotypic cryoglobulins were exclusively found in patients with either persistent or aggressive chronic hepatitis. Mixed cryoglobulins with a monotypic component were associated with all histological grades of liver damage. This study affords an objective evaluation of both the frequency and immunochemical features of cryoglobulins associated with chronic inflammatory liver disease.
Idioventricular Rhythm in Acute Myocardial Infarction: A Reappraisal.
Authors: Edwin L. Rothfeld
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Idioventricular Rhythm in Acute Myocardial Infarction: A Reappraisal.Edwin L. Rothfeld, M.D., F.A.C.P., I. Richard Zucker, M.D., William A. Leff, M.D., F.A.C.P., Victor Parsonnet, M.D.Edwin L. Rothfeld, M.D., F.A.C.P.Search for more papers by this author, I. Richard Zucker, M.D.Search for more papers by this author, William A. Leff, M.D., F.A.C.P.Search for more papers by this author, Victor Parsonnet, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-821_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptControversy exists regarding the incidence, electrogenesis, clinical manifestations, management, and prognosis of idioventricular rhythm in acute myocardial infarction, a mechanism originally described by us. This report documents our recent experience with idioventricular rhythm and attempts to resolve this dilemma. Idioventricular rhythm occurred in 68 of 300 consecutive patients with acute myocardial infarction monitored by a relay telemetric system. Unlike paroxysmal ventricular tachycardia, idioventricular rhythm had a gradual onset and a rate that rarely exceeded 100/ min. It usually arose as a ventricular escape mechanism in the setting of sinus bradycardia or marked sinus arrhythmia. Idioventricular rhythm was seen more commonly... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Edwin L. Rothfeld, M.D., F.A.C.P.; I. Richard Zucker, M.D.; William A. Leff, M.D., F.A.C.P.; Victor Parsonnet, M.D.Affiliations: Newark, NJ. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5 Page: 821-821 Keywords Acute myocardial infarction Arrhythmia Bradycardia Ventricular tachycardia ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...
60 Metabolic significance of hepatic steatosis in non alcoholic fatty liver disease and HCV chronic hepatitis
Authors: E. Bugianesi, E. Vanni, A. Gastaldelli, E. Gentilcore, R. Gambino, B. Uberti, M. Cassader, G. Pagano, E. Ferrannini, M. Rizzetto
Journal: Journal of Hepatology (2004)
Search Committee For New NCI Director Reports to White House
Authors: C. K. Wittenberg
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Search Committee For New NCI Director Reports to White House Get access Clarissa K. Wittenberg Clarissa K. Wittenberg Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 18, 16 November 1988, Pages 1438–1439, https://doi.org/10.1093/jnci/80.18.1438 Published: 16 November 1988
Practice Gaps “Down There”
Authors: Lynette J. Margesson
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Representation of M.R.C. Staff
Authors: R. West
Journal: BMJ (1970)

they have not made clear that two out of three of the seven-year survivors were in fact treated for 9 months and 22 months respec- tively by haemodialysis in other units before referral to the Royal Free, and contempor- aries of these patients at the other units concerned have died in the interim period.While in no way wishing to detract from the extremely successful results they report, it is clear that a higher mortality rate exists with this treatment when methods are being developed and there is staff inexperience.-Iam, etc..
Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias
Authors: S. Zhao, M. Konopleva, M. Cabreira-Hansen, Z. Xie, W. Hu, M. Milella, Z. Estrov, G. B. Mills, M. Andreeff
Journal: Leukemia (2003)
Local Treatment of Bronchial Asthma with Hydrocortisone Powder
Authors: H. Herxheimer, M. K. McAllen, D. A. Williams
Journal: BMJ (1958)

_~~~~~~FIA JOUNA an adverse hyperkinetic factor, and gradual involution of the muscular pulmonary arteries.In Eisenmenger's syndrome with aorto-pulmonary or interventricular shunt, this favourable cycle is prevented by a powerful hyperkinetic factor which maintains the pulmonary artery pressure at systemic level.So long as pulmonary hypertension is maintained vasocon- strictor tone is not inhibited and the muscular pulmon- ary arteries do not involute.Obliterative pulmonary vascular disease due to reac- tive "endarteritis fibrosa" is secondary and is rarely found in infancy.Thrombo-obstructive lesions are relatively late and may not be demonstrable before adult life.The different behaviour of cases with atrial septal defect may be explained by the relatively slow involu- tion of the right ventricle after birth.The pulmonary vascular resistance may well fall to normal before right ventricular diastolic tone is reduced sufficiently to allow a critical interatrial shunt, and, once the resistance is truly normal, flows up to 24 litres per minute do not cause pulmonary hypertension.The practical application of these observations to the treatment of the Eisenmenger syndrome is discussed.This analysis was begun in 1948 and two attempts at synthesis were made previously; the first in conjunction with Dr. J. B.Lowe in 1950, the second with Dr. H. Gilmour in 1953; and, though both attempts proved unsatisfactory owing to lack of sufficient data, I want to express my great indebtedness to these two colleagues.
Gallium Scan Without Hepatic or Renal Activity
Authors: ROBERT J. COOMBS, S. THEODORE PINSKY
Journal: Clinical Nuclear Medicine (2000)

A 78-year-old woman was hospitalized for chest pain and shortness of breath 3 years after a coronary artery bypass graft. Shortly after admission, a fever and elevated leukocyte count developed that necessitated a Ga-67 scan to identify the cause of sepsis. Although the Ga-67 scan did not find a specific cause of sepsis, the scan revealed a lack of normal uptake within the liver and the kidneys. The patient had combined liver failure manifested by elevated bilirubin and liver enzyme levels and renal failure indicated by elevated blood-urea nitrogen and creatinine concentrations.
Does Alexithymia in Male Alcoholics Constitute a Negative Factor for Maintaining Abstinence?
Authors: Marcin Ziółkowski, Tomasz Gruss, Janusz K. Rybakowski
Journal: Psychotherapy and Psychosomatics (1995)

The purpose of this study was to assess the prevalence of alexithymia by means of the Toronto Alexithymia Scale (TAS) in 60 male outpatients with alcohol dependence showing various durations of abstinence. Alexithymia (> or = 74 points on TAS) was found in 48% of subjects. In patients with a shorter duration of abstinence (< 1 year) both total scores of TAS as well as the scores for all three subscales were significantly higher than in subjects abstaining for more than 1 year. The findings may suggest a negative relationship between alexithymia and maintaining abstinence in male alcoholic outpatients.
Letter from Latvia: surviving surveillance.
Authors: A L Kinmouth, J Lazovskis
Journal: BMJ (1991)

During my stay in Riga (one of the oldest cities in Europe' and capital of a country about the same size as the Republic of Ireland with a population of 2 5 million) I spoke at the Ministry ofHealth and at the First Children's Hospital. I was privileged to have Professor I Lazovskis (Juris's father and professor of internal medicine at the Latvian Medical Academy) as my interpreter. As we sat in the park near the opera house discussing the lectures, Professor Lazovskis commented that if he had been speaking English like this a year ago a KGB officer would probably have appeared to ask for an explanation. It is hard to comprehend the effect of this continual surveillance; until recently the BMJ arrived in Latvia with articles such as those by Ryan on Soviet health care2 removed. In one talk I presented some data about inequalities of health among children in the United Kingdom, illustrated by death rates by occupational class. The audience were unwilling to believe the data; it was too reminiscent of propaganda of the Breznev era, rejection of which has led to a belief that everyone in the West is very well off. Comparable data on child health in the Soviet Union are neither readily available nor reliable, at least in part because of the practice of setting central planning norms for medical' activities, and then applying pressure locally for them to be met. This can result in a divergence between actual and reported activity. castle ofBaron Von Wulf(now a secondary school) still brooding over its moat and outbuildings. These now form part of the collective farm, which with the squat local Soviet headquarters, cafe-restaurant, public library, factories for bread and cheese, and queues for these commodities in the shops make up the heart of the village. The polyclinic is staffed by Dr Lazovskis, a paediatrician, a gynaecologis-t, midwife, two nurses, a dentist and dental technician, a laboratory technician, a pharmacist and eight assistants, one notes clerk, washers up, oven lighters, and a chauffeur. Dr Lazovskis tried initially to meet the planned preventive targets for the 2200 adults of Cesvaine; 80% were to be screened annually and 200 were to be put on the chronic disease registers and seen four times a year. With the nurse he set up an intricate colour coded agesex and morbidity index with separate registers for chronic disorders. (At risk occupations such as teachers, health workers, library workers, milkmaids, and war veterans are all to be examined two to four times a year.) Every evening the nurse brought the lists up to date. The nurse wrote 5000 letters in one year to try to get the patients to come. Initially, they did come, but the queues were long and the computer returns took months to come back. When they did, a countrywoman might discover that she must visit the neurologist in the town 15 km away for her headaches, see the narcologist for her smoking habit, and consult the gastroenterologist for her dyspepsia. Gamely, she may have tried to consult, only to find that two doctors
A previously undescribed hereditary hair anomaly (pseudo-monilethrix)
Authors: B. BENTLEY-PHILLIPS, MARGARET A.H. BAYLES
Journal: British Journal of Dermatology (2006)

Journal Article A previously undescribed hereditary hair anomaly (pseudo‐monilethrix) Get access B. BENTLEY‐PHILLIPS, B. BENTLEY‐PHILLIPS Department of Dermatology, University of Natal, and King Edward VIII Hospital, Durban, South Africa Reprint requests to: Dr B.Bentley‐Phillips, 708 Eagle Building, West Street, Durban, Natal, South Africa. Search for other works by this author on: Oxford Academic Google Scholar MARGARET A.H. BAYLES MARGARET A.H. BAYLES Department of Dermatology, University of Natal, and King Edward VIII Hospital, Durban, South Africa Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 89, Issue 2, 1 August 1973, Pages 159–167, https://doi.org/10.1111/j.1365-2133.1973.tb02952.x Published: 01 August 1973 Article history Accepted: 10 January 1973 Published: 01 August 1973