tbuckley/cabot-search huggingface dataset:
Complications of cannulation of the ascending aorta for open heart surgery
Authors: F. D. Salama, A. Blesovsky
Journal: Thorax (1970)

In a series of 420 ascending aortic cannulations for cardiopulmonary bypass, major complications occurred in three patients. Aortic dissection occurred in one patient believed to be due to aortic cross-clamping. Avoidance of this manœuvre is suggested when the aorta is grossly atheromatous. Two patients developing false aneurysms due to mediastinal infection are described. Prevention of mediastinal infection and its treatment are discussed. The method of treatment of false aneurysms by deep hypothermia is described.
Hyperlipidemia Due to Oxymetholone Therapy
Authors: Robert D. Reeves
Journal: JAMA (1976)

Marked hypertriglyceridemia and hypercholesterolemia accompanied by angina and a left cerebral thrombosis occurred in a long-term hemodialysis patient following 5 1/2 weeks of oral treatment with oxymetholone, 100 mg/day, a synthetic androgen. After androgen therapy was discontinued, over a three-month period, plasma lipid values progressively decreased below pretreatment values, and clinical symptoms disappeared. During rechallenge with oxymetholone, serum lipid values increased substantially, and the lipoprotein pattern changed from a type IV to a type V. Detailed lipid studies showed subnormal postheparin lipolytic activity and a fast-migrating pre-β-lipoprotein in the very-low-density lipoproteins (VLDL) fraction. Because of the data linking lipid abnormalities to atherosclerosis and the acceleration of atherosclerosis in long-term hemodialysis patients, great caution should be exercised in administering androgenic steroids to these patients. (<i>JAMA</i>236:469-472, 1976)
Targeting the TGFβ pathway for cancer therapy
Authors: Cindy Neuzillet, Annemilaï Tijeras-Raballand, Romain Cohen, Jérôme Cros, Sandrine Faivre, Eric Raymond, Armand de Gramont
Journal: Pharmacology & Therapeutics (2014)

The TGFβ signaling pathway has pleiotropic functions regulating cell growth, differentiation, apoptosis, motility and invasion, extracellular matrix production, angiogenesis, and immune response. TGFβ signaling deregulation is frequent in tumors and has crucial roles in tumor initiation, development and metastasis. TGFβ signaling inhibition is an emerging strategy for cancer therapy. The role of the TGFβ pathway as a tumor-promoter or suppressor at the cancer cell level is still a matter of debate, due to its differential effects at the early and late stages of carcinogenesis. In contrast, at the microenvironment level, the TGFβ pathway contributes to generate a favorable microenvironment for tumor growth and metastasis throughout all the steps of carcinogenesis. Then, targeting the TGFβ pathway in cancer may be considered primarily as a microenvironment-targeted strategy. In this review, we focus on the TGFβ pathway as a target for cancer therapy. In the first part, we provide a comprehensive overview of the roles played by this pathway and its deregulation in cancer, at the cancer cell and microenvironment levels. We go on to describe the preclinical and clinical results of pharmacological strategies to target the TGFβ pathway, with a highlight on the effects on tumor microenvironment. We then explore the perspectives to optimize TGFβ inhibition therapy in different tumor settings.
A Modified Technique for Endoscopic Mucosal Resection of Small Early Gastric Carcinomas
Authors: K. Takechi, M. Mihara, Y. Saito, J. Endo, H. Maekawa, T. Usui, H. Moriwaki, Y. Muto
Journal: Endoscopy (1992)

Endoscopic gastric mucosal resection (EGMR) is increasingly employed in early gastric cancer to remove the tumour with the surrounding mucosa and part of the submucosa after submucosal saline injection and staining to define the extent of the lesion. This study presents preliminary experience with a modified EGMR technique in five patients which allows more precise targeting and resection of the lesions. The time required for this procedure was less than 30 minutes in each case. All lesions were completely removed. In two patients, however, tumour growth invaded the submucosa and these patients therefore underwent subsequent surgery. Three patients with carcinoma confined to the mucosa were tumour-free at follow-up with repeat endoscopy and biopsy after 7 to 23 months.
Amazons go shopping
Authors: Mary E Black
Journal: BMJ (2006)

detectives found Mollie Jamieson at the shop where she worked in Melbourne, Australia, and told her bluntly that her 21 year old daughter, Carolyn, was dead.Mollie and her husband were then interrogated for hours over what they knew of their daughter's illegal abortion.But it was the first they knew of it.Such was the shame surrounding abortion that Carolyn had been unable to tell her parents of the real reason she was going away on "holiday."Carolyn was the last woman known to have died from illegal abortion in Victoria before a 1969 judicial ruling that abortion was lawful if necessary to protect a woman from serious danger to life or health.Her death also had another important effect-it horrified a former military doctor, Bertram Wainer, so much that he gave up his general practice in Melbourne to push for abortion law reform.Wainer's partner in this high profile and dangerous campaign was Jo Richardson, a university student activist whom he met through the Abortion Law Reform Association, and who later became his wife.Together they set up Australia's first openly operating abortion clinic in 1972.In 1985 Mollie Jamieson was one of hundreds of women who responded to an advertisement placed by Dr Wainer in a Melbourne newspaper asking for people's stories of abortion."The next generation must know what it was like for women," the advertisement said.Two years later, Dr Wainer died.For almost 20 years, Jo Wainer carried with her the yellowing transcripts of the interviews that had emerged from people who responded to the advertisement.Finally, she felt the time was right to publish them in Lost: Illegal Abortion Stories, a slim book that packs a powerful emotional punch.
METHODS FOR THE REDUCTION OF HUMAN TUBERCULOSIS OF BOVINE ORIGIN
Authors: W. G. Savage
Journal: BMJ (1929)

ETIOLOGY OF SILICOSIS.[I TDIC BN alid in the form of silica flour as the best of all bases for adsorbent toilet powders.The thlree cases of fatal silicosis reported by Dr. Lennane, Sir Bernard Spilsbury, and Dr. Macdonald, which occurred in girls employed in packing these powders, were beyond all comparison more rapid in their development than any cases of silicosis previously reported.The girls were aged 17, 19, and 23 years at the time of death.These cases had not beenl published when Mr. Green and I wrote our paper.The confirmatory evidenice which they afford in favour of the colloidal theory of silicosis is so strofig that it appears to put the correctness of the tlheory almost beyond doubt, for the combinatioll of alk'ali anid silica in finie subdivision only re1ui cs wetting for the immediate production of active silica hydrosol.The solution so formed is not a true solu- tion of a definite chemical individual comiipound, but is a variable svstem of sadium oxide, silica, and water, in whiclh, according to Weisser, the ratio of Na0O to SiO, may vary from I: 1 to 1: 4, and the uncombined silica is in the hydrosol state.18Hence the colloidal activity of the silica begins immediately the dust has reached thle lungs, inistead of awaiting the slow hydration of' the quartz larticles in the pulmonary tissue by the very faintly alkaline tissue juices, as in the case of gritstonie miasons, quartz crushers, ganister miners, and so oni.The belief that the quartz dust particles are slowly bydrated into silica sol in the lungs is founided mainly upon thle experimenital work of Gye and Kettle.'2The latter showed that such hydration occurred wlhen powdered silica was buried in the tissues of guinea-pigs.With a view to comparing this observation with a laboratory test in vitro Mr. Joseph Race, biochemist to the Devonshire Hospital, Buxtoln, put up a lnumber of substances containing silica * Working with a grant from the Medlical Re-earcli Counieil.
TCT-266 A Randomized Comparison of Transradial versus Transfemoral Approach for Coronary Artery Bypass Graft Angiography and Intervention (the RADIAL CABG trial)
Authors: Tesfaldet T. Michael, Shuaib Abdullah, Mohammed E. Alomar, Aristotelis Papayannis, Owen Mogabgab, Vishal G. Patel, Bavana Rangan, Michael Luna, Jeffrey L. Hastings, Jerrold Grodin, Subhash Banerjee, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2013)
Electrophysiological effects of flecainide in a canine 7 day old myocardial infarction model
Authors: T. SAKAI, S. OGAWA, M. HOSOKAWA, T. MIYAZAKI, K. SAKURAI, Y. NAKAMURA
Journal: Cardiovascular Research (1989)

Flecainide has been reported to be effective in suppressing chronic ventricular arrhythmias in clinical studies, but the electrophysiological mechanisms of its action are not understood. We therefore studied its effects on re-entrant ventricular arrhythmias in eight dogs with 7 day old infarction. Epicardial mapping and local refractory periods were obtained using 48 channel bipolar electrodes attached to the epicardium. Epicardial conduction velocity was significantly depressed by flecainide (2 mg.kg-1 intravenously), from 49.3 (SD 11.9) cms-1 to 35.3(11.2) cm s-1 (p less than 0.01). Flecainide prolonged effective refractory periods (ERP) in the normal, border and infarct zones: normal (n = 93), from 189.5 (15.9) to 219.3 (17.7) ms, p less than 0.01; border (n = 54) from 187.4(24.0) to 225.2 +/- 32.5 ms, p less than 0.01; and infarct (n = 93), from 197.7 (30.6) to 247.1 (34.2) ms, p less than 0.01. However, the percent change in refractoriness was greater in the infarct zone than in the normal zone, at 25.7(17.1)% v 16.2 (10.3)%, p less than 0.01. Furthermore, an area of functional unidirectional conduction block developed within the infarct zone where the maximal dispersion of ERP was observed. Inducible sustained ventricular tachycardia (SVT) was prevented in one dog and slowed (300 to 150 beats.min-1) in another by flecainide, while ventricular fibrillation remained inducible in one dog. Pro-arrhythmic effects were observed in two of five dogs without inducible SVT. In conclusion, flecainide significantly depressed conduction velocity and prolonged local refractoriness in the epicardial myocardium.(ABSTRACT TRUNCATED AT 250 WORDS)
Evaluation of the hydrogen breath test in man: definition and elimination of the early hydrogen peak.
Authors: G Mastropaolo, W D Rees
Journal: Gut (1987)

After ingestion of a non-absorbable carbohydrate breath hydrogen excretion increases early at about 10 minutes, and again later when the ingested carbohydrate enters the caecum. The late rise has been used as a marker of mouth to caecum transit time, but the source of the early rise has not been satisfactorily explained. We studied in 60 healthy volunteers the source and frequency of the early rise in breath hydrogen after ingestion of a non-absorbable carbohydrate. After ingestion of either lactulose solution (10 g in 150 ml water), lentil soup (46 g carbohydrate) or solid meal containing baked beans (15 g carbohydrate), breath hydrogen was significantly raised above basal concentrations within 10 minutes (81 +/- 27, 395 +/- 138 and 110 +/- 52% above basal respectively). A significant rise in breath hydrogen (75 +/- 21%) occurred 10 minutes after sham lactulose feeding (lactulose applied to oral cavity but not swallowed), but no early peak occurred after sham saccharin feeding (non-fermentable carbohydrate), intragastric or intraduodenal administration of lactulose. Ten of the 12 subjects given lactulose sham feeding were restudied after oral hygiene with chlorhexidine mouthwash. In these the early hydrogen peak was abolished. Oral hygiene also reduced the occurrence and magnitude of the early hydrogen rise after lactulose ingestion. These findings indicate that the early rise in breath hydrogen observed after ingestion of lactulose is produced by interaction with oral bacteria.
The Trials and Tribulations of Percutaneous Coronary Intervention in Hospitals Without On-site CABG Surgery
Authors: Scott Kinlay
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Methotrexate Therapy for Psoriasis-Reply
Authors: Jerome L. Shupack
Journal: JAMA (1988)

<h3>In Reply. —</h3> The foregoing letters report two additional cases of pancytopenia from low-dose methotrexate therapy and propose three different explanations for its occurrence. Dr Nierenberg's thoughtful letter emphasizes drug interaction between methotrexate and nonsteroidal drugs as the cause of pancytopenia. This is indeed possible; however, only five of the eight patients were taking nonsteroidal drugs, and a vast number of individuals routinely combine the two drugs without adverse effect. The answer cannot be quite so simple. Drs Burke and Jones report a patient who had the coincidence of folate deficiency and pancytopenia while taking methotrexate. The patient had no further episodes of cytopenia after his folate level was corrected. This letter presents an intriguing possibility and a subject worthy of organized investigation. Drs Grigg and Hare report a woman with chronic renal insufficiency who developed pancytopenia while being treated with methotrexate, sulfonamides, and captopril. They invoke displacement from plasma
TULAREMIA: REPORT OF FIVE CASES
Authors: John L. Lavan
Journal: JAMA (1926)

In connection with my work as city epidemiologist, the five cases of tularemia here reported were encountered in Kansas City during the month of December. According to Francis, these are the first authentic cases of tularemia ever to be reported in Missouri. The infection came from two places, one from rabbits killed near Peculiar, Mo., and the other from rabbits shot at Fontana, Kan., a small place near Kansas City, Mo. All five cases presented a typical history and proved very resistant to ordinary methods of treatment. Tularemia was thought of as soon as it came to my attention, and with the assistance of Dr. Glover, who is attached to the food and dairy division of the health department, the cases were rounded up and worked out. Diagnosis was confirmed by agglutination tests of blood sent to Washington for that purpose. <h3>REPORT OF CASES</h3><h3>Case 1.</h3> —J. E. J., a
THE CLINICAL VALUE OF HALLUCINATIONS IN LOCALIZING BRAIN TUMORS
Authors: SIDNEY TARACHOW
Journal: American Journal of Psychiatry (1941)

One or more types of hallucinations were experienced by 96 out of a group of 458 cases of supratentorial brain tumor. Formed auditory hallucinations were related predominantly to temporal lobe lesions, though the frontal and parietal were also involved. Unformed auditory hallucinations were related predominantly to frontal and temporal lesions, though all the lobes were involved as well as midline lesions notably the pituitary: in lobe lesions the hallucinations were usually on the side of the lesion. Although pure occipital lobe lesions gave rise to only visual hallucinations, either formed or unformed or xanthopsia, formed and unformed visual hallucinations were related to lesions in all the lobes of the brain in almost equal distribution, the temporal showing a slight predominance. Xanthopsia seemed related to occipital lobe lesions. Olfactory hallucinations were related to lobe lesions throughout the entire brain, though mainly to the temporal, with frontal and parietal next in descending order. Tactile hallucinations appeared with lesions of the frontal, parietal and temporal lobes. Although the panietal lobe gave rise to the widest variety of types of hallucinations, pure parietal lobe lesions gave rise to a relatively high incidence of tactile hallucinations. Gustatory hallucinations tended to appear together with olfactory hallucinations and to be related to temporal lobe lesions. It was noted that the temporal was the lobe most frequently involved by all tumors, and that the panietal and temporal are the two centrally located lobes in the brain. The occipital lobe seemed most restricted to only visual hallucinations. Though there are tendencies for certain types of hallucinations to be predominantly related to certain lobes of the brain, these hallucinations also tend to be caused by adjacent or distant lobes.
Acute Myocardial Infarction in a Nineteen-Year-Old Student in the Absence of Coronary Obstructive Disease
Authors: James J. Sidd, Harvey G. Kemp, Richard Corlin
Journal: New England Journal of Medicine (1970)

BEFORE diagnostic coronary angiography, a relation between ischemic heart disease and coronary obstructive disease was assumed. Recent studies have demonstrated the presence of myocardial ischemia and occasionally subendocardial necrosis in the presence of normal coronary arteriograms.1 2 3 4 This report documents an unusual case of acute transmural myocardial infarction in a young man without coronary obstructive disease.Case ReportK.G., a 19-year old college student, was admitted to the Newton-Wellesley Hospital in August, 1967, because of retrosternal chest pain with radiation to the jaw and left arm of 4 hours' duration. He had experienced 4 or 5 similar episodes of exertional pain . . .
Jagged1, a Ligand for Notch Receptor Expressed on Dendritic Cells, Regulates Airway Hyperresponsiveness and Inflammation by Initiating Th2 Responses
Authors: M. Okamoto, K. Takeda, H. Matsuda, A. Joetham, J. Domenico, J.J. Lucas, E.W. Gelfand
Journal: Journal of Allergy and Clinical Immunology (2009)
Hyponatremia and Ultramarathons
Authors: W. Douglas B. Hiller
Journal: JAMA (1986)

<h3>To the Editor.—</h3> We read with great interest the article by Frizzell et al<sup>1</sup>in the Feb 14 issue of<i>JAMA</i>. We are certainly in agreement with the authors concerning the serious nature of hyponatremia in ultraendurance athletes in whom hyponatremia is a real and potentially life-threatening problem. In our prospective study<sup>2</sup>in 1984 at the Ironman Triathlon World Championship in Hawaii, we were very surprised to find hyponatremia in 29% of the study subjects. However, we would like to differ with one major point made in the Frizzell article and in the article by Noakes et al<sup>3</sup>to which the authors refer. It was postulated by both Frizzell et al and Noakes et al that these hyponatremic athletes were overhydrated. The only direct evidence in support of this is the weight gain of one athlete (a 4.5-kg gain by case 4 in the Noakes et al
Do Patients with Panic Disorder Show a Memory Bias?
Authors: Eva Neidhardt, Irmela Florin
Journal: Psychotherapy and Psychosomatics (1998)

&lt;b&gt;Background:&lt;/b&gt; Cognitive models of panic disorder are becoming more and more influential. Therefore, research specifying cognitive processes related to panic disorder is needed. The present study investigated memory bias for panic-related material in patients with panic disorder. &lt;b&gt;Methods:&lt;/b&gt; Memory bias for panic-related material was investigated experimentally by a memory task requiring classification of panic-related and non-panic-related words. Sixty patients with panic disorder and 60 controls with no diagnosis of a mental disorder participated in the study. &lt;b&gt;Results:&lt;/b&gt; As expected, panic patients showed smaller differences in the time needed for classification of panic-related versus non-panic-related material than controls. &lt;b&gt;Conclusions:&lt;/b&gt; Patients with panic disorder show a memory bias for panic-related material when conceptual implicit recall is required. In order to clarify whether this bias is involved in the maintenance of the disorder, it seems important to investigate whether the bias is still present after successful therapy.
Skin disease is common in rural Nepal: results of a point prevalence study
Authors: S.L. Walker, M. Shah, V.G. Hubbard, H.M. Pradhan, M. Ghimire
Journal: British Journal of Dermatology (2007)

Background Skin problems are the commonest reason for people accessing healthcare services in Nepal but there is little information about the prevalence of skin disease. Objectives To perform a point prevalence study of skin disease in the Terai region of Nepal. Methods Five villages were randomly selected in Bara District in the Terai region of Nepal, and 878 people were examined. Results The number of individuals identified as having a skin disease was 546. The point prevalence of identifiable skin abnormalities was 62·2% (546 of 878) (with 95% exact confidence intervals 58·9–65·4%). A wide range of dermatoses was identified. The six most prevalent were dermatophyte infections (11·4%), followed by pityriasis versicolor (8·9%), acne (7·7%), melasma (6·8%), eczema (5·6%) and pityriasis alba (5·2%). Overall, treatable skin infections and infestations were by far the commonest skin diseases identified. Conclusions Our study has demonstrated a very high point prevalence (62·2%) of skin disease in rural Nepal. This study represents the first formal survey of skin disease in Nepal and demonstrates a large burden of disease, in particular treatable infections.
P1127 SIMEPREVIR (TMC435) WITH PEGINTERFERON/RIBAVIRIN FOR TREATMENT OF CHRONIC HCV GENOTYPE 1 INFECTION IN TREATMENT-NAIVE EUROPEAN PATIENTS IN THE QUEST-1 AND QUEST-2 PHASE III TRIALS
Authors: G.R. Foster, I.M. Jacobson, G.J. Dore, M. Fried, M. Manns, P. Marcellin, F. Poordad, E.S. Affonso de Araujo, M. Peeters, O. Lenz, S. Ouwerkerk-Mahadevan, G. De La Rosa, R. Kalmeijer, R. Sinha, M. Beumont-Mauviel
Journal: Journal of Hepatology (2014)
891 IMPORTANCE OF HLA-DQB1*0301 AS PREDICTIVE FACTOR OF SUSTAINED VIROLOGIC RESPONSE (SVR) IN PATIENTS WITH CHRONIC HEPATITISC (CHC), GENOTYPE-1, TREATED WITH PEGINTERFERON (PEGIFN) AND RIBAVIRIN (RBV)
Authors: P. Muñoz de Rueda, M.A. López-Nevot, J. Casado, A. Martín-Casares, L. Rodríguez, R. Quiles, M. Romero-Gómez, M. Diago, A. Martín, J.A. Muñoz, A. Ruiz-Extremera, J. Salmerón Escobar
Journal: Journal of Hepatology (2009)