tbuckley/cabot-search huggingface dataset:
A Systematic Approach to Disposition Decisions
Authors: THODORE W. LOREI, LEE GUREL
Journal: American Journal of Psychiatry (1971)

The authors report an attempt to apply a decision-theoretic approach to solving the problem of deciding whether or not to release a patient from a psychiatric hospital. Personnel from various disciplines in 12 Veterans Administration hospitals developed an "outcome inventory" that represented the major concerns hospital staff members had when they were considering whether a patient should be released or retained. The authors believe that use of the outcome inventory approach will enable a decision maker to keep his thinking straight and preclude any one feature of the problem from achieving undue importance.
A STRAIN OF CONNECTIVE TISSUE SEVEN YEARS OLD
Authors: Albert H. Ebeling
Journal: The Journal of Experimental Medicine (1919)

1. A strain of connective tissue is still very active after more than 7 years of life in vitro. 2. The rate of growth of the fragments of tissue can be measured accurately and used for testing the action of many different factors on the growth of connective tissue cells. 3. The rate of growth of the strain is at least as rapid as it was 5 years ago, and may be more active. 4. The connective tissue cells appear to have the power of multiplying indefinitely in a culture medium, as do microorganisms.
Celecoxib reduces microvessel density in patients treated with nasopharyngeal carcinoma and induces changes in gene expression
Authors: R.A. Soo, J. Wu, A. Aggarwal, Q. Tao, W. Hsieh, T. Putti, K.B. Tan, W.L. Soon, Y.F. Lai, B. Mow, S. Hsu, K.S. Loh, L. Tan, P. Tan, B.-C. Goh
Journal: Annals of Oncology (2006)
A calcium antagonist, nifedipine, modifies exercise-induced asthma.
Authors: P J Barnes, N M Wilson, M J Brown
Journal: Thorax (1981)

In eight extrinsic asthmatic subjects (age range 16-38 years) there was a significant reduction (p less than 0.01) in the severity of bronchoconstriction after a treadmill exercise test performed 30 minutes after nifedipine 20 mg sublingually. The maximum fall in peak expiratory flow after exercise was 36.0 +/- SEM 5.3% compared with a maximum fall of 56.5 +/- 4.1% after matched placebo capsules when given in double-blind randomised manner on separate days. There was no significant resting bronchodilation or change in blood pressure or heart rate after nifedipine. there was a significant rise in venous plasma histamine during exercise with placebo (6.1 +/- 0.8 to 13.5 +/- 3.5 nmol/l, p less than 0.01) but no significant increase with nifedipine (4.6 +/- 0.6 to 4.7 +/- 0.6 nmol/l) suggesting that nifedipine inhibits the release of mast cell mediators. The dose of inhaled histamine which provoked a 20% fall in peak expiratory flow was also significantly higher (p less than 0.05) with nifedipine (1.5 +/- 0.31 mg/ml) compared with placebo (2.7 +/- 0.63 mg/ml), indicating that there is a small inhibitory effect on bronchial smooth muscle contractility. Nifedipine is a potent antagonist of calcium ion influx in smooth muscle and secretory cells, and these studies suggest that it may inhibit release of mast cell mediators and reduce bronchial smooth muscle contractility in asthma.
Down-modulation of the C/EBPα transcription factor in core binding factor acute myeloid leukemias
Authors: Daniela Cilloni, Sonia Carturan, Enrico Gottardi, Francesca Messa, Emanuela Messa, Milena Fava, Daniela Diverio, Angelo Guerrasio, Francesco Lo-Coco, Giuseppe Saglio
Journal: Blood (2003)
Tuberculosis: The Nature of the Diagnostic Problem
Authors: MILES J. BREUER
Journal: Annals of Internal Medicine (1930)

Article1 June 1930Tuberculosis: The Nature of the Diagnostic ProblemMILES J. BREUER, M.D., F.A.C.P.MILES J. BREUER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-12-1272 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is now dawning on the rank and file of the medical profession that the diagnosis of pulmonary tuberculosis does not depend on the finding of the tubercle bacillus in the sputum. The days are over when one suspected tuberculosis, searched a few slides for bacilli, and finding none, decided to remove the patient's appendix. The realization is no longer rare that there are many cases, even for advanced ones, without bacilli in the sputum, and even without sputum.It was comforting to have such a convenient diagnostic test as that to make our diagnosis for us and relieve us... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MILES J. BREUER, M.D., F.A.C.P.Affiliations: Lincoln, Nebraska PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1930Volume 3, Issue 12Page: 1272-1278KeywordsBacillusSputum ePublished: 1 December 2008 Issue Published: 1 June 1930 PDF downloadLoading ...
Matrix Metalloproteinase 9 and Transglutaminase 2 Expression at the Ocular Surface in Patients with Different Forms of Dry Eye Disease
Authors: Pasquale Aragona, M'Hammed Aguennouz, Laura Rania, Elisa Postorino, Margherita Serena Sommario, Anna Maria Roszkowska, Maria Grazia De Pasquale, Antonina Pisani, Domenico Puzzolo
Journal: Ophthalmology (2014)
Guaiacol -- a new compound in the treatment of gastro-oesophageal reflux?
Authors: R V Heatley, B K Evans, J Rhodes, M Atkinson
Journal: Gut (1982)

The effects on the oesophagus of an aromatic oil, guaiacol, has been examined in a group of 20 patients with reflux oesophagitis and also normal volunteers. This agent produced a rapid and sustained rise in resting lower oesophageal sphincter pressures and the peristaltic pressures induced in response to swallowing liquids. This compound may prove useful in the treatment of patients with reflux oesophagitis and other disorders of oesophageal motility.
Coronary arterial thrombolysis with combined infusion of recombinant tissue-type plasminogen activator and urokinase in patients with acute myocardial infarction.
Authors: E J Topol, R M Califf, B S George, D J Kereiakes, D Rothbaum, R J Candela, C W Abbotsmith, C A Pinkerton, D C Stump, D Collen
Journal: Circulation (1988)

To determine whether tissue-type plasminogen activator (t-PA) and urokinase (UK) act synergistically to achieve coronary thrombolysis, incremental doses of both drugs were infused intravenously over 60 min. In 146 consecutive patients treated 3.0 +/- 1.0 hr from symptom onset, coronary angiography was performed 90 min after the start of the infusion and at 7 days. The groups of patients treated by different dose regimen were as follows: group I, 14 patients treated with t-PA 25 mg and UK 0.5 million U; group II, 20 patients given t-PA 25 mg and UK 1.0 million U; group III, 24 patients given t-PA 1.0 mg/kg and UK 0.5 million U; group IV, 33 patients treated with t-PA 1.0 mg/kg and UK 1.0 million U; and group V, 55 patients given t-PA 1.0 mg/kg and UK 2.0 million U. In groups I and II, patency of the infarct-related vessel at 90 min was only 36% and 42%, respectively. With 1 mg/kg t-PA and increasing doses of UK (groups III to V), patency ranged from 72% to 75% (overall 73%). Repeat catheterization at 7 days demonstrated reocclusion in groups III to V in 10 of 110 (9%). The patency and reocclusion rates in groups III to V were not significantly different from those in our previous study of 386 patients treated with t-PA alone (150 mg over 6 to 8 hr). In that study the patency rate of the infarct-related vessel at 90 min was 75% (p = .66) and reocclusion occurred in 15% (p = .11).(ABSTRACT TRUNCATED AT 250 WORDS)
Prodromata in Acute Myocardial Infarction
Authors: HENRY A. SOLOMON, ADRIAN L. EDWARDS, THOMAS KILLIP
Journal: Circulation (1969)

One hundred patients admitted to a coronary care unit with acute myocardial infarction were interviewed from a structured questionnaire to evaluate the incidence and significance of prodromal symptoms. Prodromata occurred in 65% of the subjects; this is the highest incidence ever recorded. Chest pain was the most common symptom. Characteristically it was recurrent and progressive. Patients with prodromata in contrast to those without warning are more likely to have an anterior or anterolateral infarction and the damage is more likely to be nontransmural than transmural. Prodromata have a striking relationship to pre-existing angina. Patients with angina rarely are hospitalized for acute infarction without warning. Emotional stress was not correlated with the definitive attack of cardiac infarction but was associated with the development of prodromata in some patients. These observations suggest that acute myocardial infarction is usually the culmination of a dynamic pre-coronary process.
507. Engineering a Novel AAV Variant for Purification Via Immobilized Metal Affinity Chromatography
Authors: James T. Koerber, Jae-Hyung Jang Jang, Julie Yu, Ravindra Kane, David V. Schaffer
Journal: Molecular Therapy (2006)

Adeno-associated virus (AAV) is a promising vector for human gene delivery that is being explored in clinical trials for cystic fibrosis, Parkinson's Disease, Alzheimer's Disease, and alpha-1-antitrypsin deficiency. However, current purification protocols often rely upon long centrifugation steps, harsh solution conditions, and scalability issues. In addition, most novel AAV serotypes do not bind heparin sulfate, requiring the development of new affinity column, or other chromatography, strategies. Immobilized metal affinity chromatography (IMAC) has allowed for the quick and easy purification of proteins via the attachment of affinity tags such a hexahistidine (His6) sequence. Through the combination of a diverse AAV2 library and rational peptide insertions, we have successfully located an optimal insertion site for a His6 tag within the viral capsid. This mutant can be purified directly from crude cell lysate at yields exceeding 60%, while retaining near wtAAV2 gene delivery efficiency and titers on numerous cell lines in vitro. Furthermore, injection of high titer IMAC-purified vector into rat brain indicates that these vectors are capable of high efficiency gene delivery in vivo. This affinity chromatography method may provide advantages in ease of purification, purity, and scalability.
Idiopathic CD4+ T-Lymphocytopenia -- Immunodeficiency without Evidence of HIV Infection
Authors: David D. Ho, Yunzhen Cao, Tuofu Zhu, Charles Farthing, Ning Wang, Guiling Gu, Robert T. Schooley, Eric S. Daar
Journal: New England Journal of Medicine (1993)

The human immunodeficiency virus (HIV), the etiologic agent of the acquired immunodeficiency syndrome (AIDS), infects and depletes CD4+ T lymphocytes. Recently, patients have been described with profound CD4+ T-lymphocytopenia but without evident HIV infection, a condition now termed idiopathic CD4+ T-lymphocytopenia, and a national surveillance network has been set up to investigate such cases.
Extensive HLA-driven viral diversity following a narrow-source HIV-1 outbreak in rural China
Authors: Tao Dong, Yonghong Zhang, Ke Yi Xu, Huiping Yan, Ian James, Yanchun Peng, Marie-Eve Blais, Silvana Gaudieri, Xinyue Chen, Wenhui Lun, Hao Wu, Wen Yan Qu, Tim Rostron, Ning Li, Yu Mao, Simon Mallal, Xiaoning Xu, Andrew McMichael, Mina John, Sarah L. Rowland-Jones
Journal: Blood (2011)
Chylomicron-retinyl palmitate clearance in type I hyperlipidemic families.
Authors: D L Sprecher, S L Knauer, D M Black, L A Kaplan, A A Akeson, M Dusing, D Lattier, E A Stein, M Rymaszewski, D A Wiginton
Journal: Journal of Clinical Investigation (1991)

Our primary aim was to determine the extent to which intraplasmic retinyl palmitate (RP) transfers to other lipoprotein particles when chylomicron remnants are not produced and/or the plasma RP residence time is increased. The study was conducted on three familial type I hyperlipoproteinemic patients, four lipoprotein lipase (LpL)-deficient heterozygotes, and three controls on a metabolic research unit. To each subject, a fat load was administered containing 16% of total daily calories in type I patients, 40% in heterozygotes and controls, plus 60,000 U/m2 vitamin A. Triglyceride (TG) and RP levels were evaluated in chylomicron and nonchylomicron fractions. Delay in the clearance of chylomicron fraction RP and the marked deficiency in nonchylomicron-RP (presumed lack of remnant production) in all three type I patients suggests that RP does not demonstrate significant intraplasmic transfer from chylomicrons to existent apolipoprotein B100 particles. In contrast to noncoincident TG and RP peaking in the normal subject, heterozygotes were found to demonstrate coincident plasma TG and RP curves, which is consistent with a common catabolic pathway for both TG and RP and inconsistent with intraplasmic RP transfer. This corroborates reports on compromised chylomicron clearance in heterozygotes. We conclude that RP is an appropriate representative marker for intestinally derived particles in LpL-deficient or partially deficient individuals.
Randomized, Double-Blind, Placebo-Controlled Trial of Evofosfamide (TH-302) in Combination with Pemetrexed in Advanced Non-Squamous Non-Small Cell Lung Cancer
Authors: J. Goldman, C. Belani, S. Novello, J. von Pawel, T. Csoszi, S. Orlov, S. Kroll, T. Pearce
Journal: Annals of Oncology (2015)
THE REVISION OF THE UNITED STATES PHARMACOPEIA
Authors: ROBERT A. HATCHER
Journal: JAMA (1925)

Dr. Lyman Spalding and his associates, who originated the United States Pharmacopeia, would be astonished, were they here today, to learn that it is necessary to point out its advantages to this audience since it was controlled by physicians alone during the first thirty years of its development. We are prone to assume that the Pharmacopeia concerns only pharmacists, and that we have no interest in the details of the work of revision. This is an unfortunate attitude, detrimental alike to pharmacy and to medicine. Many pharmacists and chemists give their best efforts to the development of the Pharmacopeia, they are indefatigable in their efforts to secure high standards of purity of official drugs, and it is patent to all who have given the subject careful study that they take far more interest than most physicians in the work of revision. It is impossible, however, to develop a pharmacopeia which
Review of "A Wind in Africa"
Authors: MICHAEL KENNEY
Journal: Annals of Internal Medicine (1976)

Comments1 September 1976Review of "A Wind in Africa"MICHAEL KENNEY, M.D., D.T.M., F.A.C.P.MICHAEL KENNEY, M.D., D.T.M., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-3-405 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I have read in the May 1976 issue a review by Dr. William B. Greenough III of Dr. Pascal James Imperato's A wind in Africa. Since I have read this book, I wish to comment on the book and this review.Having spent many years in Africa as a medical officer, I can appreciate that Dr. Imperato's successfully vaccinating millions of Africans under trying conditions was indeed a signal achievement. This achievement was recognized by the reviewer, but I was dismayed by the unwarranted criticisms of Dr. Imperato's magnificent account of his five years in Mali. Clearly,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Institute of Pathology Kings County Hospital Center Brooklyn, NY 11203 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1976Volume 85, Issue 3Page: 405-405 Issue Published: 1 September 1976 PDF downloadLoading ...
P1-228: A combination phase I study of topotecan with carboplatin for relapsed small cell lung cancer: Results of West Japan Thoracic Oncology Group trial (WJTOG0202)
Authors: Nobuhiko Seki, Tatsuhiko Kashii, Takayasu Kurata, Koji Takeda, Masahiro Tsuboi, Toshiro Miwa, Ryotaro Morinaga, Masashi Kobayashi, Taroh Satoh, Masahiro Fukuoka
Journal: Journal of Thoracic Oncology (2007)
Inflammatory properties of recombinant tumor necrosis factor in rabbit skin in vivo.
Authors: M Rampart, W De Smet, W Fiers, A G Herman
Journal: The Journal of Experimental Medicine (1989)

We have investigated the ability of recombinant TNF (mouse and human) to produce acute inflammatory lesions in an established experimental model of inflammation. Upon intradermal injection in rabbit skin, TNF, in amounts as low as 3 x 10(-14) mol/site, was found to be very potent at inducing local neutrophil accumulation and neutrophil-dependent oedema formation, thereby fulfilling two important criteria to be considered as an inflammatory mediator. Our findings further indicate that the pro-inflammatory properties of TNF are probably more related to its immediate stimulatory effects on neutrophils rather than to its slow (protein biosynthesis-dependent effects on endothelial cells. Our data thus show that very low amounts of mouse and human recombinant TNF can initiate an acute inflammatory reaction in vivo in rabbit skin and that TNF is able to evoke two of the four cardinal signs of inflammation.
Hodgkin's Disease Confined to Jejunum
Authors: G. L. Robinson
Journal: BMJ (1948)

EDICALJOsAL might have been due to maternal toxaemia.A case of true knot in the cord causing foetal distress during labour was described recently by Price (1947).Incidence of Cord Complications Cord complications are rare, but the foetal death rate due to them is very high.DeLee gives the foetal death rate in treated cases as 40-50 % and in untreated cases as 80%.In this series the foetal death rate in treated cases was 40.5%.Because of this rarity it is difficult for any one person to get sufficient experience in the treatment of cord complications, and this is one reason why the foetal death rate will always remain high.Early diagnosis and adequate treatment are essential, and two necessities for treatment are an intelligent and well-trained nursing staff and a resident obstetrician.
P284 A Questionnaire Study Of Electronic Cigarette Usage In Patients Attending Respiratory Clinics In A District General Hospital
Authors: A. Macfoy, E. Crawford, K. Srinivasan, H. Moudgil
Journal: Thorax (2014)

<h3>Background/objectives</h3> In the UK there are now more than two million users and more than 400 variations on electronic cigarettes (e-cigarettes) based on nicotine strength, flavours, devices etc. Despite the exponential rise in the use of e-cigarettes primarily as an adjunct to quit smoking strategies, the drive has predominantly been patient led and industry marketed with medical profession reluctant to engage, citing potential toxic effects as yet uncertain. Reporting from semi-rural community and focusing on respiratory patients attending respiratory clinics, objectives were to (1) document the current smoking pattern of our patients, (2) investigate their prior health seeking behaviour with respect to quit smoking, and (3) more specifically with respect to e-cigarettes address some of the questions raised with respect to where the medical profession may still have a role. <h3>Methods</h3> Prospective, self-completed, questionnaire based survey of patients (&gt;75%) attending respiratory clinic first three weeks July 2014, <h3>Results</h3> Of 78 patients, mean ((range) age was 63 (17–91) years with 49% male. Of these, 17 were smokers, 32 ex-smokers, and 29 never smokers. 42/49 (86%) had previously attempted to quit smoking; 26/42 had used no outside support, two had used nicotine gum or patches, three used drug therapies including Zyban or Champix, seven had used a combination, and four had used other unspecified techniques. 11/49 (22.4%) of those who had ever smoked had tried e-cigarettes: average set up was £23.33 with purchase on-line for three, specialist shops for four, market stalls for two, supermarket for one, and for one patient it was a gift. Only one patient had prior concerns about harmful effects, with two others asking and two others specifically being told by their retailer. Similarly, only two were given advice about suitable dosing based on baseline nicotine use, and two others about how to plan use and weaning. <h3>Conclusions</h3> Although based on a small number of patients, the high use of e-cigarettes is recognised as is the intention to quit smoking. Importantly, the survey identifies a need for patient education about use and potential for harm and it is important that we now actively engage.
XXII. Intractable paroxysmal tachycardias which proved fatal in type A Wolff-Parkinson-White syndrome.
Authors: C Brechenmacher, P Coumel, None Fauchier J-P, None Cachera J-P, T N James
Journal: Circulation (1977)

Paroxysmal tachycardias proved fatal in a middle-aged man with type A Wolff-Parkinson-White syndrome. Efforts to control his arrhythmias included a surgical incision into the left atrium, based on discovery of early left ventricular activation during epicardial mapping. The incision did not alter any electrocardiographic or clinical feature; at later necropsy examination it was found that the incision had not cut a nearby left atrioventricular (A-V) connection. Serial section study of the entire A-V rings and septal junction of this heart also demonstrated a second unusual A-V connection, between the atrial septum and the region of the His bundle. This latter connection was anatomically eccentric to the normal organization of this region and may have caused an alteration in the local electrophysiological behavior. The left lateral A-V connection may have been of no electrophysiological significance since it was composed of ordinary working myocardial cells. These and other possible correlations are discussed in the context of the clinical features, numerous electrophysiological observations, and the meticulously determined anatomical findings.
THE DURATION OF IMMUNITY TO PLASMODIUM KNOWLESI MALARIA IN RHESUS MONKEYS
Authors: J. Maier, L. T. Coggeshall
Journal: The Journal of Experimental Medicine (1944)

Rhesus monkeys with experimental Plasmodium knowlesi infections of varying duration were treated with sodium sulfathiazole to sterilize the infection and after differing lengths of time were reinoculated intraperitoneally with homologous strains of the plasmodium, for the purpose of determining whether there is any acquired immunity to malaria in hosts from whom all parasites have been removed. Two monkeys, one receiving sulfathiazole on the 2nd day of acute infection and the other on the 4th day, had no immunity at the time of reinoculation, 3 weeks and 10 weeks later, respectively. Both developed infections which followed the course usual in an acute attack in a normal monkey. In monkeys which survived acute infection with the aid of immune serum or quinine and in which a naturally acquired immunity had developed to the point where the acute infection was converted into a chronic one, there was an undoubted persistence of partial immunity up to about a year after sterilization of the infection with sulfathiazole, as indicated by recovery of reinoculated animals after mild or moderately severe infections differing widely in characteristics from the infection in the normal monkey. The end point at which immunity disappears seems to be independent of the length of the chronic infection.