tbuckley/cabot-search huggingface dataset:
New prime minister makes a clean sweep in health team
Authors: Nicholas Timmins
Journal: BMJ (2007)

NHS Employers, the organisation responsible for employment procedures in the NHS, defended its vetting practices this week after seven doctors and medical students-six in the United Kingdom and one in Australia-were held by police in connection with the failed car bombings in London and Glasgow.One doctor, Iraqi born Bilal Abdullah, who worked as a locum doctor at the Royal Alexandra Hospital, in Paisley, near Glasgow, was arrested at the scene of Saturday's attempt to blow up a jeep packed with gas cylinders at Glasgow airport.Another man detained at the scene with 90% burns is thought to be a junior hospital doctor.He is in the Royal Alexandra Hospital.Later that day, the 26 year old Jordanian born doctor Mohammed Asha and a 27 year old woman, thought to be his wife, were arrested in Sandbach, Cheshire, northwest England.Dr Asha, whose family comes originally from Palestine, had worked as a junior doctor at the Royal Shrewsbury Hospital and the Princess Royal Hospital, in Telford.In a statement NHS Employers said that all NHS hospitals "carry out rigorous checks before they appoint any member of staff, including verification of identity, qualifications, registration, and eligibility to work in the UK."The nature of their work means that staff are dealing with people who are vulnerable, and we need to be confident that patients are safe."It added, "While doing all they can to prevent unsuitable people taking up employment in the NHS, employers also have a duty to look after the rights of their staff, and this includes not discriminating against employees in any way on the grounds of their religion or belief." NHS defends vetting after doctors held for bombing bidsUK NEWS Economist says NICE should approve fewer costly drugs, p11 World NEWS �ost US surgeons in training get needlestic�� in�uries, few report them, p1� �ost US surgeons in training get needlestic�� in�uries, few report them, p1� , p1� bm�.comEgypt tightens ban on female genital mutilation after 1�� year old girl dies Egypt tightens ban on female genital mutilation after 1�� year old girl dies
The clonality of CD3+ CD10+ T cells in angioimmunoblastic T cell lymphoma, B cell lymphoma, and reactive lymphoid hyperplasia
Authors: Da Zhang, Carol J. Saunders, Weiwei Zhao, Mark Davis, Mark T. Cunningham
Journal: American Journal of Hematology (2009)

T cells coexpressing CD3 and CD10 are a characteristic feature of angioimmunoblastic T-cell lymphoma (AITL) [1]. However, they are not unique to AITL, as these cells are also present in B cell lymphoma and reactive lymphoid hyperplasia [2]. To determine the significance of CD3+ CD10+ T cells, we used flow cytometry with cell sorting and molecular biology techniques for T cell gene rearrangement to study T cells from patients with AITL, B cell lymphoma, and reactive lymph node hyperplasia. We found that CD3+ CD10+ T cells in B cell lymphoma and reactive lymphoid hyperplasia were polyclonal. In early stage of AITL, they were oligoclonal, and became monoclonal as AITL progressed. These findings illustrate the differences between early and late lymphoma and could be important for the diagnosis of AITL.
Fatal Cardiac Tamponade
Authors: Richard H. Merrill
Journal: JAMA (1983)

<h3>To the Editor.—</h3> Drs Sheep and Guiney recently reported a case of fatal cardiac tamponade after left internal jugular vein catheterization. Since we have recently published our experience with a similar complication using a dialysis catheter,<sup>1</sup>I would like to make two comments concerning this article. Drs Sheep and Guiney discuss the possibility of perforation during insertion caused by vessel-tip erosion of a vein wall. Although they state that perforation may occur during the threading of a rigid catheter using the Seldinger technique, they conclude that this is unlikely because of the flexibility of the guidewire at both ends. I would like to call attention to the fact that not all guidewires are flexible at both ends, and, indeed, the guidewires that we use for dailysis (Cobe Laboratory guidewire for femoral dialysis catheters) are flexible at only one end. Furthermore, I would like to repeat our admonition that perforation
The need for chaperones. Is greatest during intimate examination.
Authors: R N Palmer
Journal: BMJ (1993)

Atomic force microscopy was used to study adsorption and adhesion peculiarities of interferon α-2a on glass and mica surfaces. The specific protein adsorption behavior as a function of the pH value was illustrated on mica by single molecule imaging, while adhesion forces between interferon molecules and inner surfaces of borosilicate glass vials were measured directly under aqueous buffer conditions by force microscopy. We found that the adhesion force on Schott FIOLAX Type I plus® was reduced by 40% of the total adhesion force measured on Schott FIOLAX®, a standard type I borosilicate glass quality. These results reflect the anticipated superiority of the special “Type I plus” coating over undesired protein adsorption to glass. In addition, this study gives insight into a new method to predict unintended protein adsorption to glass container walls and to characterize the adsorption process by force measurement.
Intravenous immunoglobulin attenuates airway inflammation through induction of forkhead box protein 3–positive regulatory T cells
Authors: Amir H. Massoud, Julie Guay, Karim H. Shalaby, Eva Bjur, Aidan Ablona, Daniel Chan, Yasaman Nouhi, Christine T. McCusker, M. Walid Mourad, Ciriaco A. Piccirillo, Bruce D. Mazer
Journal: Journal of Allergy and Clinical Immunology (2012)
THE PREVENTION AND TREATMENT OF ASPHYXIA IN THE NEW-BORN
Authors: YANDELL HENDERSON
Journal: JAMA (1928)

The first quarter of an hour after birth is the most dangerous period of life. Its mortality is as great as that of any subsequent month. No single discovery in medical science or improvement in practice could do more to save lives than would measures to avoid the losses that now occur within a few minutes after birth. There are probably no procedures in medical practice which are so nearly the same as those of the dark ages, or which have as yet been influenced so little by modern scientific knowledge, as those of the midwife or obstetrician in dealing with a nonbreathing new-born child. Perhaps an excuse may be found in the statements still contained in textbooks of physiology and obstetrics regarding the questions why the fetus does not breathe in the uterus, and why it does start to breathe after birth. This topic is generally discussed rather philosophically,
Contempo '81. Anesthesiology
Authors: J. S. Hattox
Journal: JAMA (1981)

Steady scientific progress continues to be made on broad fronts in the specialty of anesthesiology. There are several that deserve highlighting and are presented here, not necessarily in order of their importance. <h3>Invasive Monitoring</h3> Invasive monitoring continues to receive substantial attention in the literature and at postgraduate symposia. The difficult question is when to monitor and, more specifically, when to monitor pulmonary capillary wedge pressures. Guidelines for use of balloon-tipped catheters were first suggested by Swan and Ganz<sup>1</sup>in 1974. However, the topic continues to be debated heavily. One is struck with the wide spectrum of positions taken on this subject. Swan<sup>2</sup>revealed his own bias by declaring central venous pressure (CVP) monitoring to be outmoded. Mangano,<sup>3</sup>in admirable fashion, has recently made an effort to compare the CVP with the pulmonary capillary wedge pressure under varying conditions in a group of patients undergoing cardiopulmonary bypass. Simultaneous
Life Events and Manifestations of Ischemic Heart Disease
Authors: T. Theorell
Journal: Psychotherapy and Psychosomatics (1980)

Recent psychophysiological and epidemiological evidence from both retrospective and prospective research is discussed with regard to relationship between life events and ischemic heart disease. Differences in the perception of and in the physiological reactions to life events in the real life situation of myocardial infarction patients are analyzed with respect to both the individual coping styles, that are learned, and the highly complex underlying hemodynamical mechanisms, that are genetically determined to some extent. It is argued that a more complete understanding of this relationship could form a basis for preventive action.
Computerised infrared thermography and isotopic bone scanning in tennis elbow.
Authors: D Thomas, G Siahamis, M Marion, C Boyle
Journal: Annals of the Rheumatic Diseases (1992)

Thirty five cases of tennis elbow (17 unilateral, nine bilateral) were studied with infrared thermography and isotopic bone scanning. A hot focus was visualised in 16 of 17 cases of unilateral tennis elbow (94%) and in all nine cases of bilateral tennis elbow (100%) on infrared thermography, and abnormal increased epicondylar activity seen in 12 of 17 (71%) and eight of 18 (44%) cases respectively with isotopic bone scanning. Unilateral visual cooling (somatosympathetic responses) occurred in seven of 13 cases of unilateral tennis elbow (54%) with infrared thermography, and reduced perfusion in seven of 12 (58%) of similar cases with blood pool isotopic bone scanning. Computerised temperature assessments showed statistically significant side to side temperature differences when 17 active tennis elbows were compared with the opposite normal elbows for spot temperatures, proximal and distal forearm gradients. Similar temperature assessments in 18 bilateral tennis elbows compared with 17 normal elbows showed significant temperature differences for elbow spot temperatures and distal forearm gradients, but not for proximal gradients.
Aspirin and Migraine: What About Women?-Reply
Authors: Julie E. Buring
Journal: JAMA (1991)

<h3>In Reply.—</h3> Drs Akama and Tsuji have noted with regret that the Physicians' Health Study of aspirin and beta carotene is being conducted entirely in men. When this randomized trial among physicians 40 to 84 years of age was begun in 1981, we had hoped to enroll both men and women. However, at that time, only one in 10 US physicians aged 40 years or over was a woman. Moreover, by the age of 60 years, women experience fewer than one third the number of coronary events in men. Thus, while we could enroll 22 071 men who would experience sufficient numbers of end points, only 2200 women could be randomized, and they would experience only a very small number of events. This was simply not an adequate sample to allow us to evaluate definitively the effects of low-dose aspirin on primary prevention of various manifestations of cardiovascular disease in
Pneumopericardium and Pneumothorax
Authors: Jason Andrade, Eve Aymong
Journal: New England Journal of Medicine (2009)

A 60-year old man presented with progressive dyspnea 3 months after undergoing uncomplicated aortic-valve replacement and mitral-valve repair for valvular insufficiency related to previous endocarditis. A chest radiograph obtained on presentation (Panel A) revealed a large pleural effusion on the right side (arrow) and an increase in the cardiac silhouette (arrowhead). Computed tomography confirmed the presence of the pleural effusion and revealed a moderate pericardial effusion. Ultrasound-guided insertion of a pigtail drainage catheter into the pleural effusion was performed, and 2.8 liters of exudative pleural fluid was removed. A chest radiograph obtained after the procedure (Panel B) showed a large . . .
Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly
Authors: E. Belloni, M. Muenke, E. Roessler, G. Traverse, J. Siegel-Bartelt, A. Frumkin, H.F. Mitchell, H. Donis-Keller, C. Helms, A.V. Hing, H.H.Q. Heng, B. Koop, D. Martindale, J.M. Rommens, L.-C. Tsui, S.W. Scherer
Journal: Nature Genetics (1996)
Hyperthyroidism, Hyperprolactinemia, and Macroprolactinemia
Authors: Jacobo Wortsman, William B. Malarkey
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 February 1990Hyperthyroidism, Hyperprolactinemia, and MacroprolactinemiaJacobo Wortsman, MD, William B. Malarkey, MDJacobo Wortsman, MDSearch for more papers by this author, William B. Malarkey, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-4-309_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:We read with interest the excellent review on thyrotropin-secreting pituitary adenomas by Gesundheit and colleagues (1). Elevated serum prolactin levels were found in seven of their nine patients. Although the presence of hyperprolactinemia in the setting of hyperthyroidism is unusual, the abnormality is not confined solely to thyrotropin-secreting tumors. In several patients, hyperthyroidism has also been associated with macroprolactinemia, a nontumoral entity characterized by high circulating levels of prolactin molecules of very large molecular weight (macroprolactin) (2). Abnormally elevated concentrations of macroprolactin have been found in both men and women (3) and do not usually interfere with...References1. GesundheitPetrickNissim NPM. Thyrotropin-secreting pituitary adenomas: clinical and biochemical heterogeneity-case reports and follow up of nine patients. Ann Intern Med. 1989;111:827-35. LinkGoogle Scholar2. JacksonWortsmanMalarkey RJW. Characterization of a large molecular weight prolactin in women with idiopathic hyperprolactinemia and normal menses. J Clin Endocrinol Metab. 1985;61:258-64. CrossrefMedlineGoogle Scholar3. WortsmanCarlsonMalarkey JHW. Macroprolactinemia as the cause of elevated serum prolactin in men. Am J Med. 1989;86:704-6. CrossrefMedlineGoogle Scholar4. JacksonWortsmanMalarkey RJW. Persistence of large molecular weight prolactin secretion during pregnancy in women with macroprolactinemia and its presence in fetal cord blood. J Clin Endocrinol Metab. 1989;68:1046-50. CrossrefMedlineGoogle Scholar5. MalarkeyJacksonWortsman WRJ. Long term assessment of patients with macroprolactinemia. Fertil Steril. 1988;50:413-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1990Volume 112, Issue 4Page: 309-309KeywordsAttentionHyperthyroidismPituitary tumorsProlactin Issue Published: 15 February 1990 PDF downloadLoading ...
House dust mites and human dander
Authors: H.‐I. Beck, P. Bjerring
Journal: Allergy (1987)

The occurrence of house dust mites was measured in the homes of 12 patients with the scaly skin disease, psoriasis. The median number of mites in the mattress dust and floor dust was 27 (range 10-153)/0.1 g and 56 (range 12-114)/0.1 g respectively, which is significantly higher than the background pollution of house dust mites in normal Danish homes. The results support the idea that the amount of mites in our homes not only depend on relative air humidity but also on the production of dandruff.
Legionnaires' Disease
Authors: Derek Oldenburger
Journal: JAMA (1979)

THIS report describes a fatal case of Legionnaires' disease and concomitant<i>Mycoplasma</i>pneumonia complicated by disseminated intravascular coagulation. <h3>Report of a Case</h3> A 55-year-old man had shaking chills, a temperature of 39.4 °C, a nonproductive cough, slight sore throat, but no rhinitis or myalgia two weeks before admission to his local hospital on May 7, 1978. Two days before admission he experienced anorexia, nausea, vomiting, and diarrhea without cramping. He smoked two packs of cigarettes daily. At the time of his admission to the hospital, his oral temperature was 40.1 °C; blood pressure, 158/74 mm Hg; respirations, 28/min; and pulse rate, 104 beats per minute. Cyanosis was not noted. The lungs were clear. There was no cardiac murmur or gallop. Chest x-ray film on May 8 showed a pneumonic infiltrate in the posterior basilar segment of the right lower lobe and the superior segment of the left lingula.
Influence of physiologic hyperglucagonemia on basal and insulin-inhibited splanchnic glucose output in normal man.
Authors: P Felig, J Wahren, R Hendler
Journal: Journal of Clinical Investigation (1976)

To evaluate the effects of physiologic hyperglucagonemia on splanchnic glucose output, glucagon was infused in a dose of 3 ng/kg per min to healthy subjects in the basal state and after splanchnic glucose output had been inhibited by an infusion of glucose (2 mg/kg per min). In the basal state, infusion of glucagon causing a 309 +/- 25 pg/ml rise in plasma concentration was accompanied by a rapid increase in splanchnic glucose output to values two to three times basal by 7-15 min. The rise in arterial blood glucose (0.5-1.5 mM) correlated directly with the increment in splanchnic glucose output. Despite continued glucagon infusion, and in the face of stable insulin levels, splanchnic glucose output declined after 22 min, returning to basal levels by 30-45 min. In the subjects initially receiving the glucose infusion, arterial insulin concentration rose by 5-12 muU/ml, while splanchnic glucose output fell by 85-100%. Infusion of glucagon causing an increment in plasma glucagon concentration of 272 +/- 30 pg/ml reversed the inhibition in splanchnic glucose production within 5 min. Splanchnic glucose output reached a peak increment 60% above basal levels at 10 min, and subsequently declined to levels 20-25% below basal at 30-45 min. These findings provide direct evidence that physiologic increments in plasma glucagon stimulate splanchnic glucose output in the basal state and reverse insulin-mediated inhibition of splanchnic glucose production in normal man. The transient nature of the stimulatory effect of glucagon on splanchnic glucose output suggests the rapid development of inhibition or reversal of glucagon action. This inhibition does not appear to depend on increased insulin secretio.
Comment: The Non-Hodgkin's Lymphomas
Authors: Philip Rubin
Journal: JAMA (1973)

Many conceptual parallels in the diagnosis and treatment of non-Hodgkin's disease lymphomas have been stimulated by or derived from the Hodgkin's disease experience. The necessity for a unified classification of the anatomic extent of disease for all types of malignant lymphomas was presented earlier in this series. It is evident that the pathologic criteria and nomenclature must be reassessed in order to allow the clinician to decide on principles of management and recognize evolution of the disease. Rappaport<sup>67</sup>initiated identification of specific cell types in the lymphoproliferative and reticuloproliferative series, and gross nodal patterns of diffuse and nodular varieties. This plan has been adapted more recently by Lukes<sup>68</sup>and Butler<sup>69</sup>with the specific aim of eliminating the confusion caused by the terms lymphosarcoma and reticulum cell sarcoma (Table 4). The malignant lymphomas are divided into nodular and diffuse varieties with specific cell types: lymphocytic well differentiated and
Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance
Authors: Jun Yoshino, Caterina Conte, Luigi Fontana, Bettina Mittendorfer, Shin-ichiro Imai, Kenneth B. Schechtman, Charles Gu, Iris Kunz, Filippo Rossi Fanelli, Bruce W. Patterson, Samuel Klein
Journal: Cell Metabolism (2012)
Two-dimensional echocardiography and Doppler color flow mapping in the diagnosis and prognosis of ventricular septal rupture.
Authors: F Helmcke, E F Mahan, N C Nanda, S P Jain, B Soto, J K Kirklin, A D Pacifico
Journal: Circulation (1990)

Doppler color flow mapping in conjunction with two-dimensional echocardiography was used to evaluate ventricular septal rupture after myocardial infarction (seven anterior and eight inferior) in 15 patients and to correlate these findings with cardiac catheterization and surgical or autopsy data. Ventricular septal rupture was diagnosed by turbulent flow traversing the ventricular septum. The direction and velocity of shunt flow was determined by color M-mode and conventional Doppler methods. In all patients, Doppler color flow mapping correctly defined the site of septal rupture, which occurred at areas of discordant septal wall motion or "hinge points" (six posterior inlet, three anterior inlet, and six apical trabecular septum). Each of three patients with moderate tricuspid regurgitation and three of four patients with right-to-left shunting during diastole died, and all had an elevated right ventricular end-diastolic pressure. Right ventricular wall motion index was significantly higher in the patients who died compared with those who survived (mean +/- SEM; 2.8 +/- 0.2 vs. 2.0 +/- 0.2, p = 0.012), but there was no difference in left ventricular wall motion index. The rupture size measured by Doppler color flow imaging (1.7 +/- 0.1 cm) correlated with the size determined during surgery or autopsy (1.8 +/- 0.2 cm, r = 0.68, p = 0.022) and the pulmonic-to-systemic shunt flow ratio by cardiac catheterization (2.4:1 +/- 0.3, r = 0.74, p = 0.004). Color-guided continuous-wave Doppler estimates of right ventricular systolic pressure (47 +/- 2 mm Hg) correlated with cardiac catheterization measurements (48 +/- 3 mm Hg, r = 0.90, p = 0.0002).(ABSTRACT TRUNCATED AT 250 WORDS)
Postmarketing Follow-up
Authors: Hershel Jick
Journal: JAMA (1979)

THERE is a general but strongly held view that, after drugs are marketed, additional epidemiologic information is needed on their clinical effects, particularly adverse effects. This notion is based soundly on the limited size and scope of the clinical experience with a drug before marketing. Recently, considerable interest has been evident in this area and has focused on the term "postmarketing surveillance" (PMS). That the interest is widespread and intense is reflected in the many meetings that have taken place, articles that have been written, and committees that have been formed to consider the designing of large formal systems of PMS.<sup>1-15</sup>Given the diffuse nature of the subject, it is essential to take an objective and informed look at the legitimate needs in this area and to consider practical means of satisfying these needs. Without a clear understanding of the nature of the problems that can be addressed epidemiologically
Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue.
Authors: A C Bianco, J E Silva
Journal: Journal of Clinical Investigation (1987)

The effect of thyroxine (T4) and triiodothyronine (T3) on the expression of uncoupling protein (UCP) in rat brown adipose tissue (BAT) has been examined. Thyroidectomized rats have a threefold reduction in basal UCP levels. When exposed to cold, they become hypothermic and show a fivefold lower response of UCP than euthyroid controls. T3 augments the basal levels and the response of UCP and its mRNA to cold in a dose-dependent manner. However, to normalize the response of UCP, T3 has to be given in a dosage that produces systemic hyperthyroidism. Mere T3 replacement corrects the systemic hypothyroidism but not the hypothermia or the low levels of UCP. In contrast, replacement doses of T4 prevent the hypothermia and correct the UCP level. Both effects of T4 are blocked by preventing T4 to T3 conversion in BAT. Thus, the optimal UCP response to cold and protection against hypothermia require a high BAT T3 concentration, which is attained from euthyroid levels of T4 via the activation of the BAT T4 5'deiodinase during cold exposure, but not from euthyroid plasma T3 levels.