Cryoprecipitable Immune Complexes, Nephropathy, and Sickle-Cell Disease
Authors: JOSE STRAUSS
Journal: Annals of Internal Medicine (1974)

Letters1 July 1974Cryoprecipitable Immune Complexes, Nephropathy, and Sickle-Cell DiseaseJOSE STRAUSS, M.D., MICHAEL KOSS, M.D., WILLIAM GRISWOLD, M.D., WILLIAM CHERNACK, M.D., VlTORIANO PARDO, M.D., RAWLE M. MCINTOSH, M.D.JOSE STRAUSS, M.D.Search for more papers by this author, MICHAEL KOSS, M.D.Search for more papers by this author, WILLIAM GRISWOLD, M.D.Search for more papers by this author, WILLIAM CHERNACK, M.D.Search for more papers by this author, VlTORIANO PARDO, M.D.Search for more papers by this author, RAWLE M. MCINTOSH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-1-114 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We have previously reported the presence of cryoproteins in immune-complex mediated glomerulonephritis in man (1) and shown that these cold insoluble serum precipitates contain antigen and specific antibody in experimental serum sickness (2). Previously (3, 4), we described an immune complex glomerulonephropathy associated with sickle-cell disease and implicated renal tubular antigen in the pathogenesis of the renal lesion. We report here the isolation and characterization of a cold insoluble complex of renal tubular antigen and antibody from a patient with sickle-cell nephropathy and autologous immune complex nephritis.Blood was obtained from a patient with sickle-cell disease and...References1. MCINTOSHKAUFMANKULVINSKAS RDC: Cryoglobulin I: the nature, incidence and clinical significance of cryoglobulins in glomerulonephritis. J Lab Clin Med 75:566-577, 1970 MedlineGoogle Scholar2. GRISWOLDHSUMCINTOSH WKR: Cryoprecipitates and immune complexes: decrease in antibody bound 131I-labeled BSA antigen after cryoprecipitation in rabbit serum. Proc Soc Exp Biol Med 142:1292-1294, 1973 CrossrefMedlineGoogle Scholar3. PARDOKRAMERLEVI VHD: Glomerular changes in patients with sickle cell disease and the nephrotic syndrome (abstract). Am J Pathol 70:4a, 1973 Google Scholar4. STRAUSSPARDOKRAMER JVH: Sickle cell nephropathy and autologous immune-complex nephritis (abstract). Clin Res 22:98a, 1974 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Departments of Pediatrics and Pathology University of Miami School of Medicine Miami, Florida Departments of Pediatrics and Pathology College of Physicians and Surgeons Columbia University New York, New York Departments of Pediatrics and Medicine University of Colorado Medical Center Denver, Colorado PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGENITOURINARY COMPLICATIONS OF SICKLE CELL DISEASEGENITOURINARY COMPLICATIONS OF SICKLE CELL DISEASEPrevelance and clinical correlates of glomerulopathy in children with sickle cell diseasePrevalence and Pathologic Features of Sickle Cell Nephropathy and Response to Inhibition of Angiotensin-Converting EnzymeRenal Disorders in Sickle HemoglobinemiaTherapy of Renal Disorders in Sickle HemoglobinemiaSickle Cell NephropathyChronic synovitis with early cartilage destruction in sickle cell disease.Experimental autologous immune deposit nephritis in rats associated with mercuric chloride administrationNephrotic Syndrome Associated with Fanconi Syndrome Immunopathogenic Studies of Tubulointerstitial Nephritis with Autologous Immune-Complex GlomerulonephritisMICHAEL SHWAYDER, A.B., TAKESHI OZAWA, M.D., EDWARD BOEDECKER, B.A., STEPHEN GUGGENHEIM, M.D., RAWLE M. McINTOSH, M.D.Nephropathy associated with sickle cell anemia: An autologous immune complex nephritis 1 July 1974Volume 81, Issue 1Page: 114-115KeywordsAntigensBloodGlomerulonephritisImmune complexLesionsNephritisPathogenesisRenal diseases Issue Published: 1 July 1974 PDF DownloadLoading ...