tbuckley/cabot-search huggingface dataset:
Erythema multiforme with tumour necrosis factor inhibitors: a class effect?
Authors: T Kain, D MacGregor, R R C Buchanan, J P de Jager, L Schachna
Journal: Annals of the Rheumatic Diseases (2008)

We read with interest the report by Soliotis et al 1 of erythema multiforme (EM) occurring with etanercept. Here we report a case of EM with another tumour necrosis factor (TNF) inhibitor, infliximab, which has not recurred on switching to etanercept.

One week following his third infliximab infusion, a 59-year-old man who had had ankylosing spondylitis for 6 years presented with purpuric rash over the lower legs and blistering. Other medications were telmisartan hydrochlorothiazide and fluticasone/salmeterol inhaler. A skin punch biopsy demonstrated lichenoid inflammatory reaction with focal epidermal necrosis. The rash was presumed an allergic reaction to infliximab, and promethazine and hydrocortisone premedication was …
The Clinical, Hemodynamic, and Pathologic Diagnosis of Muscular Subvalvular Aortic Stenosis
Authors: HERMANN MENGES, ROBERT O. BRANDENBURG, ARNOLD L. BROWN
Journal: Circulation (1961)

Muscular obstruction to left ventricular outflow is a rare but serious occurrence. Eight cases in which this disease was anatomically proved are presented. The commonest symptoms are angina, dyspnea, and palpitations. Not uncommonly a family history of heart disease may be elicited. A systolic murmur along the left sternal border is the most characteristic physical finding, but a normal aortic second sound, the presence of third and fourth heart sounds, splitting of the second sound, and the absence of a diastolic murmur are all helpful clinical guides. Withdrawal pressures from the left ventricle reveal a characteristic infundibular pressure zone. Other hemodynamic findings include an anacrotic notch on the left ventricular pressure tracing, a rapidly ascending bisferious aortic pulse and a small compensatory beat after extrasystoles. Necropsy specimens reveal a grossly thickened interventricular septum as compared with normal and hypertrophied control hearts. Microscopic alterations are minimal. The etiology remains obscure but familial and developmental factors, either or both, appear to be implicated.
Application of a membrane model to the sorptive interactions of humic substances.
Authors: R L Wershaw
Journal: Environmental Health Perspectives (1989)

Humic substances, the dark-colored, natural organic polyelectrolytes that are found in practically all soils, sediments, and natural water, strongly interact with both inorganic and organic pollutants. Inorganic cationic species generally undergo complexation reactions with humic substances. The binding of cations, such as cupric ions, by humic substances often markedly reduces their toxicity to aquatic organisms. Some inorganic anionic species, in the presence of metal ions, are sorbed by humic substances. In these instances the metal ions appear to form bridges between the humic substances and the anions. Several different types of interactions take place between organic compounds and humic materials. Hydrophobic organic species partition into either insoluble or soluble humic substances. The insoluble humic substances will remove hydrophobic organic compounds from the aqueous phase, thereby rendering them less mobile. However, soluble humic substances will solubilize hydrophobic organics, increasing their mobility. Other types of interactions between humic substances and organic compounds, such as adsorption and ion exchange, also have been observed. These various interactions between humic substances and pollutants are important in governing their fate and movement in natural water systems, and, for this reason, a detailed understanding of the mechanisms of the interaction is important. A recently developed membrane model of the structure of humic substances is described; this model enables one to better understand the physical-chemical properties of these materials.
Tc-99m Infecton and Tc-99m MDP Imaging in Osteomyelitis of the Hip Joint
Authors: RAJNISH SHARMA, ANUPAM MONDAL, M.K. CHOPRA, H.S. RAWAT, RAVI KASHYAP
Journal: Clinical Nuclear Medicine (2002)

SHARMA, RAJNISH D.R.M.; MONDAL, ANUPAM D.R.M., D.N.B.; CHOPRA, M.K. B.Sc.; RAWAT, H.S. B.Sc.; KASHYAP, RAVI D.R.M., D.M.R.D., D.N.B. Author Information
Efficacy of MRI visible iron oxide nanoparticles in delivering minicircle DNA into liver via intrabiliary infusion
Authors: Lin Gao, Lisi Xie, Xiaojing Long, Zhiyong Wang, Cheng-Yi He, Zhi-Ying Chen, Lei Zhang, Xiang Nan, Hulong Lei, Xin Liu, Gang Liu, Jian Lu, Bensheng Qiu
Journal: Biomaterials (2013)
Functional imaging of shear-dependent activity of ADAMTS13 in regulating mural thrombus growth under whole blood flow conditions
Authors: Yasuaki Shida, Kenji Nishio, Mitsuhiko Sugimoto, Tomohiro Mizuno, Masaaki Hamada, Seiji Kato, Masanori Matsumoto, Kazuo Okuchi, Yoshihiro Fujimura, Akira Yoshioka
Journal: Blood (2007)
"Variant" Angina Pectoris
Authors: DAVID SCHERF, JULES COHEN
Journal: Circulation (1974)

Variant" Angina PectorisClassical angina pectoris is characterized by recurrent attacks of retrosternal pain brought on by effort and emotion and relieved by rest and the administration of nitroglycerin.It is well known that this classical syndrome has many variations and modifications.In 1959, and again in 1960, Prinzmetal and his colleagues described what they called a "variant form of angina pectoris."According to these authors, this syndrome exhibits important features which differentiate it from classical angina.1 2The characteristics of the variant form of angina were listed as follows:
Trauma-induced bullae; the presenting feature of systemic amyloidosis associated with plasma cell dyscrasia
Authors: C.A. HOLDEN, M.J. WESTON, D.M. MACDONALD
Journal: British Journal of Dermatology (1982)

Journal Article Trauma‐induced bullae; the presenting feature of systemic amyloidosis associated with plasma cell dyscrasia Get access C.A. HOLDEN, C.A. HOLDEN Department of Dermatology, Guy's Hospital, London SE1 Search for other works by this author on: Oxford Academic Google Scholar M.J. WESTON, M.J. WESTON King's College Hospital, Denmark Hill, London, SE5 Search for other works by this author on: Oxford Academic Google Scholar D.M. MACDONALD D.M. MACDONALD Department of Dermatology, Guy's Hospital, London SE1 Dr D.M.MacDonald, Department of Dermatology, Guy's Hospital, St Thomas' Street, London SE1 9RT. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 107, Issue 6, 1 December 1982, Pages 701–706, https://doi.org/10.1111/j.1365-2133.1982.tb00532.x Published: 01 December 1982 Article history Accepted: 27 April 1982 Published: 01 December 1982
Surgery in Chronic Arthritis
Authors: John G. Kuhns
Journal: New England Journal of Medicine (1949)

SURGERY is employed in chronic arthritis primarily to remove or to decrease deformities and disabilities that have occurred within and about the joints.1 If adequate early medical and orthopedic care is given, almost all disability can be prevented in chronic arthritis, and much later surgery can be avoided.2 If the joints that show swelling, muscular spasm and pain are splinted to relieve muscular spasm, in a position as near to full extension as they can comfortably be placed, and if flexion deformity is then prevented by a part-time maintenance of this position, little deformity will develop. Weakness in the supporting . . .
Efficacy of physiotherapy management of knee joint osteoarthritis: a randomised, double blind, placebo controlled trial
Authors: Kim L Bennell, Rana S Hinman, Ben R Metcalf, Rachelle Buchbinder, Jenny McConnell, Gawain I McColl, Sally Green, Kay M Crossley
Journal: Annals of the Rheumatic Diseases (2005)

To determine whether a multimodal physiotherapy programme including taping, exercises, and massage is effective for knee osteoarthritis, and if benefits can be maintained with self management.Randomised, double blind, placebo controlled trial; 140 community volunteers with knee osteoarthritis participated and 119 completed the trial. Physiotherapy and placebo interventions were applied by 10 physiotherapists in private practices for 12 weeks. Physiotherapy included exercise, massage, taping, and mobilisation, followed by 12 weeks of self management. Placebo was sham ultrasound and light application of a non-therapeutic gel, followed by no treatment. Primary outcomes were pain measured by visual analogue scale and patient global change. Secondary measures included WOMAC, knee pain scale, SF-36, assessment of quality of life index, quadriceps strength, and balance test.Using an intention to treat analysis, physiotherapy and placebo groups showed similar pain reductions at 12 weeks: -2.2 cm (95% CI, -2.6 to -1.7) and -2.0 cm (-2.5 to -1.5), respectively. At 24 weeks, pain remained reduced from baseline in both groups: -2.1 (-2.6 to -1.6) and -1.6 (-2.2 to -1.0), respectively. Global improvement was reported by 70% of physiotherapy participants (51/73) at 12 weeks and by 59% (43/73) at 24 weeks. Similarly, global improvement was reported by 72% of placebo participants (48/67) at 12 weeks and by 49% (33/67) at 24 weeks (all p>0.05).The physiotherapy programme tested in this trial was no more effective than regular contact with a therapist at reducing pain and disability.
Keeping Up with the Medical Literature
Authors: MICHAEL GALLICO
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 January 1987Keeping Up with the Medical LiteratureMICHAEL GALLICO, M.A., M.Lib.MICHAEL GALLICO, M.A., M.Lib.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-1-169_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The example of literature searching used in the context of the acquired immunodeficiency syndrome (AIDS) by Dr. Haynes and colleagues (1) correctly exemplifies the dual powers of electronic retrieval, retrospective searching, and current awareness. The article itself illustrates the problem of currency of information in that it makes no reference to the growing number of information resources available in print and electronic form that deal specifically with AIDS.Although American readers would be advised to consult their reference librarians as to developments in online systems such as BRS-Colleague, the British position has also developed rapidly. An AIDS...Reference1. HAYNESMCKIBBONFITZGERALDGUYATTWALKERSACKETT RKDGCD. How to keep up with the medical literature: IV. Using the literature to solve clinical problems. Ann Intern Med. 1986;105:636-40. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1987Volume 106, Issue 1Page: 169-169KeywordsAIDS Issue Published: 1 January 1987 PDF DownloadLoading ...
A Case of Retropharyngeal Soft-Tissue Swelling: The Definitive Diagnosis Revealed
Authors: Richard E. Goulding
Journal: JAMA (1986)

To the Editor.—  I enjoyed reading the article on retropharyngeal soft-tissue swelling, 1 but I beg to differ with the diagnosis given. My conclusion is that this appeared to be a retropharyngeal abscess or possibly a phlegmon because it resolved so readily with antibiotics.  Thyroid tenderness is difficult to differentiate from anterior neck tenderness caused by an expanding abscess in the retropharyngeal or retrotracheal space. Indeed, the anterior neck will be tender in either entity. Needle aspiration of thyroid tissue will do little to detect purulent material in the retropharyngeal space.  Poor dentition, as was noted on the original physical examination, is one of the causative factors for development of an abscess. Differentiating between subacute thyroiditis and retropharyngeal abscess is not difficult. Prompt needle aspiration of the retropharyngeal space, perhaps under radiographic, ultrasound, or computed tomographic scan control, should be done. There might be some difficulty, especially in patients with rather
Effect of MCI-176, a new calcium channel blocker, on large and small coronary arteries in dogs
Authors: T. ISHIBASHI, M. NAKAZAWA, S. IMAI
Journal: Cardiovascular Research (1989)

MCI-176, a new calcium channel blocker, increases coronary blood flow and may improve perfusion in ischaemic areas. Its vasodilating effects on large conductive coronary arteries and the resistive arterioles were therefore compared with those of diltiazem, nifedipine, glyceryl trinitrate and adenosine in anaesthetised open chest beagle dogs. Intracoronary injection of these compounds caused dose dependent increases in coronary flow associated with decreases in the resistance of resistive arterioles, and the rank order of potency was nifedipine > adenosine > MCI-176 > diltiazem > glyceryl trinitrate. The resistance of the large conductive vessels was likewise reduced by these agents, except for adenosine. Glyceryl trinitrate showed the highest selectivity to the large conductive vessels, while adenosine showed the lowest and calcium channel blockers were intermediate. Among three calcium channel blockers, MCI-176 had the highest selectivity to the large conductive vessels, while the duration of action was the longest with diltiazem; the duration of action of MCI-176 was intermediate. Thus, MCI-176 is a coronary vasodilator, the potency of which is intermediate between nifedipine and diltiazem, but it has the highest selectivity to the large conductive vessels among these three compounds.
Loss of hepatic autoregulation after carbohydrate overfeeding in normal man.
Authors: J N Clore, S T Helm, W G Blackard
Journal: Journal of Clinical Investigation (1995)

To determine the effect of increased glycogen stores on hepatic carbohydrate metabolism, 15 nondiabetic volunteers were studied before and after 4 d of progressive overfeeding. Glucose production and gluconeogenesis were assessed with [2-3H] glucose and [6-14C] glucose (Study I, n = 6) or [3-3H] glucose and [U-14C]-alanine (Study II, n = 9) and substrate oxidation was determined by indirect calorimetry. Overfeeding was associated with significant (P < 0.01) increases in plasma glucose (4.97 +/- 0.10 to 5.09 +/- 0.11 mmol/liter), insulin (18.8 +/- 1.5 to 46.6 +/- 10.0 pmol/liter) and carbohydrate oxidation (4.7 +/- 1.4 to 18.0 +/- 1.5 mumol.kg-1.min-1) and a decrease in lipid oxidation (1.2 +/- 0.2 to 0.3 +/- 0.1 mumol.kg-1.min-1). Hepatic glucose output (HGO) increased in Study I (10.2 +/- 0.5 to 13.1 +/- 0.9 mumol.kg-1.min-1, P < 0.01) and Study II (11.17 +/- 0.67 to 13.33 +/- 0.83 mumol.kg-1.min-1, P < 0.01), and gluconeogenesis decreased (57.6 +/- 6.4 to 33.4 +/- 4.9 mumol/min, P < 0.01), indicating an increase in glycogenolysis. The increase in glycogenolysis was only partly compensated by an increase in glucose cycle activity (2.2 +/- 0.2 to 3.4 +/- 0.4 mumol.kg-1.min-1, P < 0.01) and the fall in gluconeogenesis, thus resulting in increased HGO. The suppression of gluconeogenesis despite increased lactate and alanine (glycerol was decreased) was associated with decreased free fatty acid (FFA) oxidation and negligible FFA enhanced gluconeogenesis. These studies suggest that increased liver glycogen stores alone can overwhelm normal intrahepatic mechanisms regulating carbohydrate metabolism resulting in increased HGO in nondiabetic man.
Many junior doctors misuse drugs and drink excessively
Authors: A. Brooks
Journal: BMJ (1998)

Over a quarter of junior house officers take cannabis, and two thirds of those who drink are exceeding safe limits, says a survey published in the Lancet (1998;352:785-6).

The researchers contacted 114 junior house officers who had studied at Newcastle University, 90 of whom responded (51 of them women). The house officers were asked about their drinking habits, illicit drug taking, and stress levels.

Among the 93% who drank alcohol, over 60% of both sexes exceeded safe …
Family Medicine in Perspective
Authors: I. R. McWhinney
Journal: New England Journal of Medicine (1975)

Family medicine is part of the process by which medicine adjusts itself to the changing needs of society. Family physicians have in common the fact that they obtain fulfillment from personal relations more than from the technical aspects of medicine. Their commitment is to a group of people more than to a body of knowledge. Their experience gives them a distinctive perspective of illness that includes its personal and social context. Medical knowledge includes information, skill and insight. Medical education has tended to emphasize the former: to concentrate on foreground rather than background. In the training of family physicians the education setting and the role of instructors are of crucial importance.
Thalassemia Major: A Problem of Iron Overload
Authors: JAMES A. STOCKMAN
Journal: Annals of Internal Medicine (1974)

Editorials1 August 1974Thalassemia Major: A Problem of Iron OverloadJAMES A. STOCKMAN III, FRANK A. OSKIJAMES A. STOCKMAN IIISearch for more papers by this author, FRANK A. OSKISearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-2-262 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has long been recognized that the palliative treatment of beta thalassemia major is ultimately little more than the substitution of one form of chronic disease (iatrogenic iron overload), and death, for the short life associated with the natural course of the disorder. With a point d'appui for definitive therapy not yet established, the concern of the physician would be optimally focused on those factors that can reduce the burden to the body of iron and its effects on many organ systems.Desferrioxamine, shown over a decade ago to effectively chelate iron, was expected to be useful in iron overload...References1. BARRYFLYNNLETSKY MDE: Long-term chelation therapy in thalassemia major: effect on liver iron concentration, liver histology, and clinical progress. Br Med J 2:16-20, 1974 CrossrefMedlineGoogle Scholar2. BOTHWELLPIRZIO-BIROLIFINCH TGC: Iron absorption. I. Factors influencing absorption. J Lab Clin Med 51:24-31, 1958 MedlineGoogle Scholar3. : Iron in enriched wheat flour, farina, bread, buns, and rolls. JAMA 220:855-859, 1972 CrossrefMedlineGoogle Scholar4. STOCKSOFFERMANMODELL JEC: The susceptibility of auto-oxidation of human red cell lipids in health and disease. Br J Haematol 23:713-724, 1972 CrossrefMedlineGoogle Scholar5. WAPNICKLYNCHCHARLTON ASR: The effect of ascorbic acid deficiency on desferrioxamine-induced urinary iron excretion. Br J Haematol 17:563-568, 1969 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Pediatrics Upstate Medical Center State University of New York Syracuse, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited By10 Management of Cooley's anaemiaCurrent Strategies in the Management of Cooley's AnemiaChelation therapy in β-thalassemia major. III. The role of splenectomy in achieving iron balanceIron Absorption in the Thalassemia Syndromes and Its Inhibition by TeaEchocardiographic abnormalities in patients with transfusion-dependent anemia and secondary myocardial iron depositionCooley anemia: High transfusion regimen and chelation therapy, results, and perspectiveChelate Mediated Transfer of Iron from Transferrin to DesferrioxamineEnterohepatic chelating agents—I 1 August 1974Volume 81, Issue 2Page: 262-263KeywordsBeta-thalassemiaPalliative care Issue Published: 1 August 1974 PDF DownloadLoading ...
SANITATION IN PANAMA
Authors: D. P. Curry
Journal: JAMA (1922)

<h3>To the Editor:</h3> —InThe Journal, August 5, under "Medical News," you quote the Panama<i>Star and Herald</i>to the effect that an epidemic of malaria has developed among Canal Zone employees, and that breeding places of mosquitoes, which had been sprayed with oil the year round, are now neglected, with the result that there are now more mosquitoes on the Isthmus than ever before, since sanitation days; also that Ancon Hospital is overcrowded with malaria patients. I believe your readers will appreciate the truth regarding these reports, which have had a widespread circulation in United States papers. The statements of the Panama<i>Star and Herald</i>, published June 18, 1922, may be categorically denied: There is not an epidemic of malaria among the employees of the Panama Canal. Breeding places of mosquitoes, formerly sprayed with oil the year round, are not now neglected. There are not more mosquitoes on the
The potential impact of nuclear magnetic resonance imaging on cardiovascular diagnosis.
Authors: L Kaufman, L Crooks, P Sheldon, H Hricak, R Herfkens, W Bank
Journal: Circulation (1983)

Nuclear magnetic resonance (NMR) is used to generate cross-sectional images of the human body that show excellent anatomic and functional definition. The NMR imaging process involves interactions between electromagnetic fields and the hydrogen nuclei being imaged. These interactions occur on time scales of milliseconds to seconds. Consequently, the motion of these nuclei, for instance, when carried by blood, produces distinct signatures that are used to assess flow in major vessels. Myocardial dyskinesis also produces visible effects. Because of these effects, NMR imaging may be a safe and effective tool in the diagnosis and assessment of cardiovascular disease.
von Willebrand factor–mediated platelet adhesion is critical for deep vein thrombosis in mouse models
Authors: Alexander Brill, Tobias A. Fuchs, Anil K. Chauhan, Janie J. Yang, Simon F. De Meyer, Maria Köllnberger, Thomas W. Wakefield, Bernhard Lämmle, Steffen Massberg, Denisa D. Wagner
Journal: Blood (2010)