tbuckley/cabot-search huggingface dataset:
Melanoma Screening by Physicians
Authors: Marilyn R. Wickenheiser, Jeremy S. Bordeaux, June K. Robinson
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Avoiding backward steps in COPD: looking again at roflumilast
Authors: L.M. Blasco
Journal: European Respiratory Journal (2011)

To the Editors:

I read with interest the article by Bateman et al . [1] on the influence of roflumilast when it is used concomitantly with long-acting β2-agonists to reduce exacerbations. Similarly, roflumilast remained effective with concomitant short-acting muscarinic antagonists. Phosphodiesterase (PDE)4 inhibitors have arisen as anti-inflammatory drugs that may prevent exacerbations in moderate to severe chronic obstructive pulmonary disease (COPD) patients who fulfil the chronic bronchitis profile. Preclinical investigations suggest that roflumilast mitigates tobacco smoke-induced lung inflammation, mucociliary malfunction, lung fibrotic remodelling, oxidative stress or pulmonary vascular remodelling. However, clinical studies have failed to identify inflammation biomarkers that demonstrate significant and evident anti-inflammatory effects of roflumilast.

There are two potential controversies from the basic research. First, COPD may be understood from the point of view of PDE4 dysfunction, which may explain systemic COPD manifestations through mechanisms …
Circulating Sezary cells in hospitalized dermatology patients
Authors: SCOTT C. DUNCAN, R. K. WINKELMANN
Journal: British Journal of Dermatology (1978)

Sézary cells in the circulation were counted daily in 14 hospitalized dermatology patients: six with contact dermatitis, five with atopic dermatitis, and three with exfoliative psoriasis. All had circulating Sézary cells, but absolute counts of Sézary cells of more than 1000/mm3 appeared to correlate with a severe refractory course in two patients. It is probable that low, intermittent levels of circulating Sézary cells accompany many inflammatory dermatoses, and it is reasonable that monitoring this cell population may aid in anticipating more consequential skin disease.
A novel therapeutic approach to psoriasis with combination calcipotriol ointment and very low-dose cyclosporine: Results of a multicenter placebo-controlled study
Authors: R.M. Grossman, J. Thivolet, A. Claudy, P. Souteyrand, J.J. Guilhou, P. Thomas, P. Amblard, S. Belaich, C. de Belilovsky, M. de la Brassinne, C. Martinet, J.A. Bazex, C. Beylot, P. Combemale, D. Lambert, A. Ostojic, J.P. Denoeux, Ph. Lauret, L. Vaillant, M. Weber, R. Pamphile, L. Dubertret
Journal: Journal of the American Academy of Dermatology (1994)
Predictability in Psychopharmacology: Preclinical and Clinical Correlations
Authors: J. Crammer
Journal: BMJ (1976)

addicts but will also make new converts.Attractively set out and illustrated, it is a living testament to our past.Those of us active in practice today will be reminded of our own responsibilities to future generations.During these times of high inflation our libraries need support and, more important, bequests.
Better quality data for Down's syndrome register.
Authors: D Mutton, E Alberman, R Ide, M Bobrow
Journal: BMJ (1993)

view of the great variation in management,' the results of such a trial would help women with bleeding in early pregnancy, and their general practitioners, decide what is best.Women are dissatisfied with the care that they receive when they miscarry,4 and the lack of effective treatment for threatened miscarriage probably contributes to their dissatisfaction.Perhaps, it is the medicalisation of miscarriage-a sad but common physiological event-that has greatly contributed to women's dissatisfaction.If so, we as doctors have only ourselves to blame.
DISTRIBUTION OF CONSULTANTS IN ENGLAND
Authors: H. R. Vickers
Journal: British Journal of Dermatology (1973)

Journal Article DISTRIBUTION OF CONSULTANTS IN ENGLAND Get access H. R. Vickers H. R. Vickers Blackhall Farm, Charlbury Road, Oxford 0X2 6UX Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 89, Issue 1, 1 July 1973, Pages 97–98, https://doi.org/10.1111/j.1365-2133.1973.tb01927.x Published: 01 July 1973
Abstract 4488: A synergistic effect between aldehydes and doxorubicin in S. cerevisiae provides a model for enhancing anthracycline-based therapy.
Authors: Jana S. Miles
Journal: Cancer Research (2013)

Abstract We have previously reported that interruption of the synthesis of the amino acid threonine confers sensitivity to doxorubicin in S. cerevisiae. Threonine synthesis requires the genes HOM6, THR1, and THR4, which encode the enzymes homoserine dehydrogenase, homoserine kinase, and threonine synthase, respectively. The inactivation of these genes in threonine biosynthesis results in increased toxicity of doxorubicin. Interestingly, the most sensitive strain, hom6, results in the accumulation of L-aspartate semialdehyde. We hypothesize that the accumulation of this metabolite results in toxic synergy with doxorubicin. We have further investigated the role of aldehydes in the sensitization of yeast cells to anthracyclines. Inactivation of HOM3, which encodes for the aspartate kinase required for the first step in threonine biosynthesis, prevents the accumulation of the L-aspartate semialdehyde in the hom6 strain and rescues its sensitivity to doxorubicin, suggesting a role for the aldehyde in the sensitization to doxorubicin. Furthermore, wild type strains treated with different aldehydes significantly reduced the survival of the cells to anthracyclines, and distinctly in other therapeutic agents. These results indicate that aldehydes have a synergistic effect with anthracyclines. In humans, threonine is an essential amino acid and its biosynthesis does not occur. However, our results are directly applicable to relevant human pathways in nonessential amino acids and ornithine synthesis. Potential application of the accumulation of glutamic semialdehyde and succinic semialdehyde intermediates for a synergistic effect with doxorubicin is discussed. Research supported by NIH/NCRR RCMI grant #RR03020 at Florida A&amp;M University. Citation Format: Jana S. Miles. A synergistic effect between aldehydes and doxorubicin in S. cerevisiae provides a model for enhancing anthracycline-based therapy. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4488. doi:10.1158/1538-7445.AM2013-4488
Carcinoids of the Gastrointestinal Tract
Authors: Chen Pao-Huei, Siauw Chuan-Pau, Lin Kuang-Yang, Huang Gonq-Chin, Lin Jean-Dean, Ko Hsian-Chong, Chen Ting-Yao
Journal: Endoscopy (1980)

Thirteen cases of carcinoid of the GI tract during eleven years seen in our hospital are presented. Prior to surgery, the clinical diagnosis of our 9 cases of gastric carcinoid was as follows: 7 cases were diagnosed as advanced gastric cancer, one case as perforated gastric ulcer, while a minute lesion of less than 1 cm in diameter was correctly diagnosed as a carcinoid. The tumors were all larger than 2 cm in the largest diameter with the exception of a minute lesion that appeared as a submucosal tumor and was diagnosed correctly before operation. Only one case of rectal carcinoid was diagnosed as a carcinoid endoscopically. The other two were diagnosed as rectal polyp and rectal cancer respectively. The lesion arising in the cecum was diagnosed as cecum tumor. The biopsy specimens of most carcinoids revealed adenocarcinoma pre-operatively, and only two cases were diagnosed correctly as carcinoid. In our series, we were unable to detect any symptom or sign of carcinoid syndrome, even in the case with widespread liver metastasis. We have not encountered any case of carcinoid in the appendix, which lesion has been very frequently reported in the Western countries.
Measurement of Central Blood Volume by External Monitoring
Authors: ROBERT H. EICH, WILLIAM R. CHAFFEE, ROBERT B. CHODOS
Journal: Circulation Research (1961)

Central blood volume was measured in 39 normal subjects, using external monitoring and interrupted arterial samples. The volume obtained by external counting was 15 per cent of the total blood volume, compared with 42 per cent obtained with the arterial curve. The importance of collimation and counter position was evaluated, and only with a dualcounter setup could a mean circulation time (MCT) for each ventricle be obtained. An MCT was necessary for satisfactory reproducibility of externally measured central blood volume. While the method has limitations, it does appear to offer a technique for measuring just the amount of blood in the heart and lungs with a satisfactory reproducibility, and would appear to be worth further application in problems involving measurement of central blood volume.
Managing Posthospital Care Transitions for Older Adults
Authors: Peter A. Boling
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Combined Effect of Age and Right Ventricular Involvement on Acute Inferior Myocardial Infarction Prognosis
Authors: Héctor Bueno, Ramón López-Palop, Esther Pérez-David, Javier García-García, José L. López-Sendón, Juan L. Delcán
Journal: Circulation (1998)

In patients with acute inferior myocardial infarction (AIMI), right ventricular involvement (RVI) is one of the strongest predictors of in-hospital death. We hypothesized that the impact of RVI on AIMI prognosis depends on the patient's age.The in-hospital clinical outcome of 798 consecutive patients admitted to the coronary care unit within 48 hours of symptom onset with AIMI was analyzed according to patient age and to the presence of RVI diagnosed by ECG and/or echocardiographic criteria. The total incidence of RVI was 37%, and it increased as age advanced. Patients with RVI had a significantly higher incidence of major complications (45% versus 19%, P<0.0001) and a higher in-hospital mortality rate (22% versus 6%, P<0.0001). The prognostic effect of RVI was independent of sex, smoking, diabetes, shock on admission, left ventricular ejection fraction, and reperfusion therapy, all age-dependent predictors. A multivariate analysis showed a significant (P=0.03) interaction between age and RVI on AIMI mortality. RVI increased mortality risk only in the oldest patients.In patients with AIMI, RVI substantially increases mortality risk in elderly patients, whereas it has a nonsignificant effect in young subjects.
In Vitro Studies of Taxol as a Radiation Sensitizer in Human Tumor Cells
Authors: J. Liebmann, J. A. Cook, J. Fisher, D. Teague, J. B. Mitchell
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article In Vitro Studies of Taxol as a Radiation Sensitizer in Human Tumor Cells Get access James Liebmann, James Liebmann Radiation Biology Branch, Division of Cancer Treatment, National Cancer InstituteBethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar John A. Cook, John A. Cook Radiation Biology Branch, Division of Cancer Treatment, National Cancer InstituteBethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Joyce Fisher, Joyce Fisher Radiation Biology Branch, Division of Cancer Treatment, National Cancer InstituteBethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Diane Teague, Diane Teague Radiation Biology Branch, Division of Cancer Treatment, National Cancer InstituteBethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar James B. Mitchell James B. Mitchell * Radiation Biology Branch, Division of Cancer Treatment, National Cancer InstituteBethesda, Md. * Correspondence to: James Liebmann, M.D., National Institutes of Health, Bldg. 10. Rm. B3B69. Bethesda, MD 20892. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 6, 16 March 1994, Pages 441–446, https://doi.org/10.1093/jnci/86.6.441 Published: 16 March 1994 Article history Received: 12 August 1993 Revision received: 06 December 1993 Accepted: 17 December 1993 Published: 16 March 1994
Global Threat of Heart Disease
Authors: Rebecca Voelker
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The new NHS. Freeman hospital: countdown to self government.
Authors: J Laurance
Journal: BMJ (1991)

We are three weeks away from the beginning of what will be the most profound change in the NHS since its birth over Statistics for Freer 40 years ago-and the whole world is watching.Many Hospitals (includin countries are struggling to find more cost effective ways of Hospitals anddis delivering health care, and they will be as interested as the Hospital and disabBritish to see whether the NHS experiment will enhance centre) or destroy the service.As one of our contributions to Budget: £50m monitoring the changes we have identified an NHS trust, a No of beds: 980 predominantly urban and a predominantly rural health Medical staff: 250(1000 district, and a fund holding practice.The experiences of Inpaients (989-90): 32 each will be described in a series running over the next four Day cases (1989-90): 10 (
Prenatal Management of 746 Pregnancies at Risk for Congenital Toxoplasmosis
Authors: F Daffos, F Forestier, M Capella-Pavlovsky, P Thulliez, C Aufrant, D Valenti, W L Cox
Journal: New England Journal of Medicine (1988)

When infection with Toxoplasma gondii occurs during pregnancy, there is a risk that the parasite will cause severe congenital toxoplasmosis. We developed a method of diagnosing and treating congenital toxoplasmosis in utero. Diagnosis was based on the identification of maternal acute infection, followed by culture of fetal blood and amniotic fluid, testing of fetal blood for toxoplasma-specific IgM and nonspecific measures of infection, and ultrasound examination of the fetal brain. Treatment included the administration of antibiotics to all mothers with confirmed acute infection during pregnancy, with more intensive antibiotic treatment of those who had infected fetuses and who chose to continue the pregnancy. We report a prospective study of 746 documented cases of maternal toxoplasma infection, in which the infants were followed for at least three months. Infection was diagnosed antenatally in 39 of 42 fetuses. Twenty-four of the 39 pregnancies were terminated, and 15 were continued. All the mothers were treated with spiramycin throughout pregnancy; if fetal infection was demonstrated, pyrimethamine and either sulfadoxine or sulfadiazine were added to the regimen. Of the 15 fetuses with congenital toxoplasmosis who were carried to term, all but 2, who had chorioretinitis, remained clinically well during follow-up. We conclude that prenatal diagnosis of congenital toxoplasmosis is practical and that prenatal therapy in women who wish to continue their pregnancies reduces the severity of the manifestations of the disease.
Methacholine and Histamine Inhalation Challenges in Asthma: Relationships to Age of Onset, Length of Illness, and Pulmonary Functions
Authors: S L. Spector, H. Staudenmayer, R. A. Kinsman, J. Fukuhara, C. Westmoreland
Journal: Allergy (1979)

Levels of airway's hyperreactivity, as indexed by methacholine and histamine thresholds, were determined for hospitalized asthmatic patients using the serial concentration, constant‐breath method. Airways hyperreactivity was categorized into tow and high based on a split of the sample of subjects tested. These categories were unrelated to pulmonary function measurements obtained throughout hospitalization. Patients having high airways hyperreactivity to histamine or methacholine were admitted for intensive inpatient care at a younger age, had an earlier age of onset, and had asthma of longer duration than patients having low airways hyperreactivity. These latter results suggested that relatively greater airways hyperreactivity is more likely to be associated with early onset of the illness.
Cyclin D2–Cyclin-Dependent Kinase 4/6 Is Required for Efficient Proliferation and Tumorigenesis following Apc Loss
Authors: Alicia M. Cole, Kevin Myant, Karen R. Reed, Rachel A. Ridgway, Dimitris Athineos, Gijs R. Van den Brink, Vanesa Muncan, Hans Clevers, Alan R. Clarke, Peter Sicinski, Owen J. Sansom
Journal: Cancer Research (2010)

Inactivation of the Apc gene is recognized as the key early event in the development of sporadic colorectal cancer (CRC), where its loss leads to constitutive activation of β-catenin/T-cell factor 4 signaling and hence transcription of Wnt target genes such as c-Myc. Our and other previous studies have shown that although cyclin D1 is required for adenoma formation, it is not immediately upregulated following Apc loss within the intestine, suggesting that proliferation following acute Apc loss may be dependent on another D-type cyclin. In this study, we investigated the expression and functional relevance of cyclin D2 following Apc loss in the intestinal epithelium. Cyclin D2 is upregulated immediately following Apc loss, which corresponded with a significant increase in cyclin-dependent kinase 4 (CDK4) and hyperphosphorylated Rb levels. Deficiency of cyclin D2 resulted in a reduction in enterocyte proliferation and crypt size within Apc-deficient intestinal epithelium. Moreover, cyclin D2 dramatically reduced tumor growth and development in Apc(Min/+) mice. Importantly, cyclin D2 knockout did not affect proliferation of normal enterocytes, and furthermore, CDK4/6 inhibition also suppressed the proliferation of adenomatous cells and not normal cells from Apc(Min/+) mice. Taken together, these results indicate that cyclin D-CDK4/6 complexes are required for the efficient proliferation of cells with deregulated Wnt signaling, and inhibiting this complex may be an effective chemopreventative strategy in CRC.
Abstract PR05: Reversing the oncogenic roles of misdirected chromatin remodeling: Disruption of mSWI/SNF (BAF) complexes by the SS18-SSX fusion in human synovial sarcoma
Authors: Cigall Kadoch, Gerald R. Crabtree
Journal: Cancer Research (2013)

Abstract Recent exon- and genome-wide sequencing studies of human cancers have revealed frequent mutations in genes encoding subunits of mSWI/SNF or BAF complexes and implicated them as tumor suppressors. Indeed, we estimate that they are mutated in &amp;gt;20% of human cancers (Kadoch et al, Nature Genetics 2013). Interestingly, the subunits most commonly mutated are not required for chromatin remodeling in vitro and thus may contribute to chromatin regulation in a novel way. One difficultly in understanding the oncogenic role(s) of these complexes is distinguishing primary driving mutations from passenger mutations. To investigate the mechanism underlying oncogenesis, we studied human synovial sarcoma (SS), in which transformation results from a remarkably precise and uniform translocation of exactly 78 amino acids of SSX (SSX1, 2 or 4) to the SS18 protein. In a proteomic study we discovered that SS18 is a dedicated, non-exchangeable subunit of BAF complexes. We demonstrate that the hallmark SS18-SSX fusion incorporates into BAF complexes, evicting both the wild-type SS18 protein and the tumor suppressor, hSNF5 (BAF47), which is known to be biallelically inactivated in malignant rhabdoid tumors. The altered complex binds the Sox2 locus, reversing polycomb-mediated H3K27me3 repression and activating Sox2. Sox2 is uniformly expressed in SS tumors and is essential for proliferation. Remarkably, increasing the concentration of wild-type SS18 leads to reassembly of wild-type complexes, retargeting of BAF complexes, returned polycomb-mediated repression at the Sox2 locus and cessation of SS cell proliferation. This mechanism of transformation depends on a two amino acid hydrophilic region of SSX and hence provides a potential foundation for therapeutic intervention. Citation Format: Cigall Kadoch, Gerald R. Crabtree. Reversing the oncogenic roles of misdirected chromatin remodeling: Disruption of mSWI/SNF (BAF) complexes by the SS18-SSX fusion in human synovial sarcoma. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Jun 19-22, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2013;73(13 Suppl):Abstract nr PR05.