tbuckley/cabot-search huggingface dataset:
Platelet turnover, coagulation factors, and soluble markers of platelet and endothelial activation in essential thrombocythemia: Relationship with thrombosis occurrence and <i>JAK</i>2 V617F allele burden
Authors: Eduardo Arellano‐Rodrigo, Alberto Alvarez‐Larrán, Juan‐Carlos Reverter, Dolors Colomer, Neus Villamor, Beatriz Bellosillo, Francisco Cervantes
Journal: American Journal of Hematology (2008)

Patients with essential thrombocythemia (ET) have an increased frequency of thrombosis, but the relationship of both thrombosis and JAK2 V617F allele burden with platelet turnover, acquired activated protein C resistance (aAPCR), and levels of coagulation factors and soluble markers of platelet, and endothelial activation is not well known. In 53 ET patients (26 with a history of thrombosis), reticulated platelets (RP) percentage, aAPCR, platelet tissue factor (TF) expression, and plasma levels of TF, coagulation factors, soluble P-selectin (sP-selectin), soluble CD40 ligand (sCD40L), von Willebrand factor antigen (VWF:Ag), soluble thrombomodulin (sTM), D-dimer and prothrombin fragment 1 + 2 were compared with those in matched healthy individuals and correlated with thrombosis occurrence and JAK2 mutational load. ET patients with thrombosis had significantly higher values for RP percentage, aAPCR, and levels of factors V and VIII, VWF:Ag, sP-selectin, and sCD40L than patients without thrombosis and controls. At multivariate study, RP percentage, factor V levels, and aAPCR were independently associated with an increased risk of thrombosis. Patients with JAK2 mutation had significantly lower levels of free protein S (PS) and higher levels of TF, sP-selectin, sCD40L, VWF:Ag, and sTM than those with wild-type allele. A mutant allele dosage effect (>or= 12%) was observed for TF, sP-selectin, sCD40L, VWF:Ag, and PS levels. These results support a role for platelet turnover, factor V, and aAPCR in the thrombosis of ET as well as the association between JAK2 V617F allele burden and either decreased free PS or increased TF and soluble markers of platelet and endothelial activation.
Recurrent Gastrointestinal Bleeding in Osler's Disease Successfully Treated by Endoscopic Electrocoagulation in the Stomach
Authors: J. Weingart, G. Lux, K. Elster, R. Ottenjann
Journal: Endoscopy (1975)

In a female patient with hereditary haemorrhagic telangiectasia and recurrent bleeding in the upper gastrointestinal tract, the “Osler angiomas” in the stomach were successfully treated by endoscopic electrocoagulation. Within the five years prior to the electrocoagulation, the patient had suffered from 48 bouts of gastrointestinal bleeding with haematemesis and subsequent tarry stools; a total of 36 blood transfusions had to be given. An emergency gastrotomy, carried out to stop the bleeding in the stomach remained without influence on the course of the disease. In the first three months following electrocoagulation, two episodes of gastric bleeding occurred which, however, stopped spontaneously and required no treatment; in the following 21 months, no further gastrointestinal bleeding was observed and no more blood transfusions became necessary.
An Experience with Group Practice
Authors: George A. Silver, Martin Cherkasky, Joseph Axelrod
Journal: New England Journal of Medicine (1957)

INTEREST in the development of group practice and in the mechanics of such a development has increased in the United States.1 2 3 Growth of group practice offers valuable opportunities for observing and recording different arrangements. It is important that groups report their experiences so that others may benefit from such a practical review. This description of the formation and characteristics of the Montefiore Medical Group is offered not as an exemplar but as a working model of a type of group practice.The Health Insurance Plan of Greater New York set out in 1947 to deliver to subscribers comprehensive medical care, . . .
Transient Bcl-2 gene down-expression in circulating mononuclear cells of severe sepsis patients who died despite appropriate intensive care
Authors: Pascal Bilbault, Thomas Lavaux, Abdeslam Lahlou, B�atrice Uring-Lambert, Marie-Pierre Gaub, Charline Ratomponirina, Nicolas Meyer, Pierre Oudet, Francis Schneider
Journal: Intensive Care Medicine (2004)
Scintigraphic Pattern of Skeletal Involvement of Waldenström Macroglobulinemia
Authors: Magda S. Elmonayeri, Abdelhamid H. Elgazzar
Journal: Clinical Nuclear Medicine (2008)

Serial bone scans of a case of Waldenström macroglubinemia that show progressive involvement of the sternum, clavicles, and ribs are presented. The pattern of focally increased uptake seen on bone scans associated with the patient's clinical presentation is similar to an inflammatory process. Awareness of this pattern could help in suspecting the condition if undiagnosed or making the proper interpretation when diagnosis is known as due to infiltration by this lymphoproliferative disorder rather than due to other reasons such as infection or metabolic bone disease.
CD36 and macrophages in atherosclerosis
Authors: S COLLOTTEIXEIRA, J MARTIN, C MCDERMOTTROE, R POSTON, J MCGREGOR
Journal: Cardiovascular Research (2007)

CD36 is a multi-ligand scavenger receptor present on the surface of a number of cells such as platelets, monocytes/macrophages, endothelial and smooth muscle cells. Monocyte/macrophage CD36 has been shown to play a critical role in the development of atherosclerotic lesions by its capacity to bind and endocytose oxidized low density lipoproteins (OxLDL), and it is implicated in the formation of foam cells. However, the significance of CD36 in atherosclerosis has recently been called into question by different studies, and therefore its exact role still needs to be clarified. The aim of this article is to carefully review the importance of CD36 as an essential component in the pathogenesis of atherosclerosis.
Use of Pediatric Cadaver Kidneys for Homotransplantation in Children
Authors: Richard N. Fine
Journal: JAMA (1969)

Four patients, aged 12 to 17 years, received cadaver kidneys from children aged 2 to 5 years. Three of the four recipients are surviving seven to nine months posttransplantation. Adequate renal function was attained in three of four recipients, with creatinine clearance &gt;100 ml/ min/1.73 sq m. Anatomic hypertrophy of the transplanted kidney was shown roentgenographically in three or four recipients. The results of the present study warrant the use of pediatric cadaver kidneys from donors aged 2 to 5 years for transplantation into adolescent recipients.
P2-056: Non-Small Cell Lung Cancer: Difference in Oxidative Stress and Antioxidative Defense Mechanism Between Adenocarcinoma and Squamous Cell Carcinoma
Authors: Ilkka Ilonen, Jari V. Räsänen, Eero I. Sihvo, Aija Knuuttila, Kaisa Salmenkivi, Jarmo A. Salo
Journal: Journal of Thoracic Oncology (2007)
Akt1 silencing efficiencies in lung cancer cells by sh/si/ssiRNA transfection using a reductable polyspermine carrier
Authors: Dhananjay Jere, Ji-Eun Kim, Rohidas Arote, Hu-Lin Jiang, You-Kyoung Kim, Yun Jaie Choi, Cheol-Heui Yun, Myung-Haing Cho, Chong-Su Cho
Journal: Biomaterials (2008)
The Journal Itself.
Authors: D. Colvin
Journal: JAMA (1896)

Clyde, N. Y., June 12, 1896. <h3>To the Editor:</h3> —With great pleasure I acknowledge the receipt of my much wished for copy of theJournalof Dec. 28, 1895. I am more than ever tenacious that there shall be no break, as, without flattery, under the present editorial conduct, it is a library of itself, and the best medical journal now published. I assume to be a competent judge, as I have been a reader of it since its first publication in the weekly form. Yours truly,
Feasibility of contact surveys in general practice.
Authors: A Phillips, D Mant
Journal: BMJ (1987)

Surveys to evaluate risk factors for disease in the general population are popular with health authorities for assessing the effectiveness of their preventive measures. A contact survey of the lifestyles of 2000 randomly selected patients aged 25-64 was conducted in five general practices over 18 months; the medical records of the patients selected were tagged, and when the patients first visited the surgery they were given a questionnaire by the receptionists, which they completed in the waiting room. Over the 18 months at least 1400 of these patients visited the practices, of whom 1106 (55%) completed a questionnaire and 20 refused to do so; 896 (81%) completed it within one year. Information on the patients who were not surveyed was obtained by sending the questionnaire by post and by audit of medical records. The population surveyed on contact with the surgeries contained a higher proportion of young women, and possibly a higher proportion of patients from social classes IIIM-V, than the other patients. No important or consistent bias towards unhealthy patients at high risk was identified in the contact survey. A one year contact survey of a random, tagged sample is feasible in estimating the risk factors in a population and may be the method of choice in general practice because of its low cost and adaptability.
Zinc Ingestion and Lipoprotein Values in Sedentary and Endurance-Trained Men
Authors: Stephen F. Crouse
Journal: JAMA (1984)

The finding that high doses (160 mg) of zinc lowered high-density lipoprotein-cholesterol prompted us to study the effect of low-dose zinc supplementation on lipoprotein values in sedentary and endurance-trained men. Twenty-one endurance-trained and 23 sedentary men received either placebo or 50 mg of zinc sulfate daily for eight weeks. Despite the fact that plasma zinc increased 15%, fasting plasma high-density-lipoprotein cholesterol, total cholesterol, low-density-lipoprotein cholesterol, and triglyceride levels did not change in response to zinc ingestion. We conclude that low-dose zinc supplementation does not affect lipid or lipoprotein values in either endurance-trained or sedentary men. (<i>JAMA</i>1984;252:785-787)
Brain SPECT Imaging in Progressive Aphasia
Authors: HENRY LEE, JOEL H. KRAMER
Journal: Clinical Nuclear Medicine (1992)

Progressive aphasia without dementia is a relatively uncommon neurobehavioral syndrome. The initial presentation of progressive aphasia without cognitive impairment may pose a diagnostic dilemma. The authors report a patient with progressive aphasia. The initial neuroimaging studies (MRI, CT) were not diagnostically helpful. However, brain SPECT imaging with Tc-99m HMPAO clearly demonstrated a left temporal lobe abnormality. This report discusses the potential clinical usefulness of brain SPECT imaging in the evaluation of neurobehavioral disorders.
Evaluation of Long-Term Use of Propranolol in Angina Pectoris
Authors: Ezra A. Amsterdam
Journal: JAMA (1969)

The effect of propranolol hydrochloride therapy for angina pectoris was evaluated by double-blind trial in 121 patients with the anginal syndrome. Ninety-five patients had coronary artery disease, and 26 had normal coronary arteries. Successful therapy was achieved in 83 patients (86%) with coronary artery disease, whereas only six (23%) with normal coronary arteries responded favorably. Not distinguishing features could be found between those patients with coronary artery disease successfully treated with propranolol and those who failed to respond. Side effects occurred in 31% of the patients but necessitated withdrawal of treatment in only two instances. These results indicate that propranolol is highly effective in the prolonged treatment of angina pectoris when this is caused by coronary atherosclerosis and the dose of drug is individualized for each patient.
Abuse of Psychotherapy: Psychotherapist-Patient Intimacy
Authors: Gerald G. Pope
Journal: Psychotherapy and Psychosomatics (1990)

An increasing number of reports in the last few decades suggest a certain breach of psychotherapist-patient fiduciary relationships in the form of sexual intimacy rationalized as 'genuine love, expressed in both word and deed' in a context of social-moral permissiveness. Around 3.1 % female to 13.7% male therapists appear to engage in some form of intimacy; 4.9% psychiatric residents have acknowledged sexual interaction with supervisors. Regulations and laws are being enacted in various jurisdictions, reducing concerns on confidentiality breach in reporting offenders. Administrative, civil and criminal options are offered to the victims of psychotherapists' sexual misconduct.
Reply to Yaalini Shanmugabavan, Stephanie Guillaumier and Hashim U. Ahmed's Letter to the Editor re: Morgan R. Pokorny, Maarten de Rooij, Earl Duncan, et al. Prospective Study of Diagnostic Accuracy Comparing Prostate Cancer Detection by Transrectal Ultrasound–Guided Biopsy Versus Magnetic Resonance (MR) Imaging with Subsequent MR-guided Biopsy in Men Without Previous Prostate Biopsies. Eur Urol 2014;66:22–9
Authors: Morgan Pokorny, Wendy Van de Ven, Jelle Barentsz, Leslie Thompson
Journal: European Urology (2014)
Conserved Herpesvirus Kinases Target the DNA Damage Response Pathway and TIP60 Histone Acetyltransferase to Promote Virus Replication
Authors: Renfeng Li, Jian Zhu, Zhi Xie, Gangling Liao, Jianyong Liu, Mei-Ru Chen, Shaohui Hu, Crystal Woodard, Jimmy Lin, Sean D. Taverna, Prashant Desai, Richard F. Ambinder, Gary S. Hayward, Jiang Qian, Heng Zhu, S. Diane Hayward
Journal: Cell Host & Microbe (2011)
Centers for Disease Control and Prevention 2006 Human Immunodeficiency Virus Testing Recommendations and State Testing Laws
Authors: Sarah Neff
Journal: JAMA (2011)

of nonteaching hospitals. 2Thus, many hospitalist programs are not part of academic hospitals.Because hospitals are not financially accountable for their patients after discharge, only those hospitals with strong commitments to quality are likely to institute programs designed to ensure continuity of care between hospitalists and patients' primary care physicians.Evidence suggests that hospitalist programs can be effective, but internal changes for efficiency do not assure better outcomes after discharge.We need empirical evidence regarding performance of a representative sample of hospitalist programs, regardless of the sponsorship under which they operate.Assuming that all programs are as effective as the literature may miss important opportunities for improving patients' experiences and outcomes.
Montelukast, a leukotriene receptor antagonist, inhibits the late airway response to antigen, airway eosinophilia, and IL-5–expressing cells in Brown Norway rats☆☆☆★
Authors: Daizo Ihaku, Lisa Cameron, Masaru Suzuki, Sophie Molet, James Martin, Qutayba Hamid
Journal: Journal of Allergy and Clinical Immunology (1999)
Functional characterization of the cells in chronic neutrophilic leukemia
Authors: Dale A. Dotten, Waldemar Pruzanski, Dean Wong
Journal: American Journal of Hematology (1982)

Abstract Light and electron microscopy of neutrophils from chronic neutrophilic leukemia (CNL) did not reveal differences from normal mature neutrophils. However, functional characterization of CNL cells showed marked differences when compared to normal cells. CNL neutrophils were much less viable in suboptimal conditions. Their survival was further reduced by autologous serum and was corrected by normal human serm. CNL cells showed very active phagocytosis, but their bactericidal activity was reduced in suboptimal conditions. The total content of lysozyme and β‐glucuronidase was lower in CNL cells compared to normal neutrophils, but the release of these enzymes from stimulated cells was much higher than normal. This observation is compatible with a marked lysosomal lability. Cells from the patients' peripheral blood and bone marrow showed excessive growth in CFU‐C assays. Marked susceptibility of CNL cells to cytotoxic activity of cold agglutinins, SLE sera, and CSFs was observed and may signify qualitative and/or quantitative differences in the membrane structure of CNL neutrophils, as compared to normal cells.
Association Between Mannose-Binding Lectin Deficiency and Immunoglobulin Subclass 4 Deficiency in Children with Recurrent Infections
Authors: M.M. Dowd, N. Tangsinmankong, D.D. Siri, A.S. Hartel, K.S. Brauer, I.N. Umeh, N.K. Day, J.W. Sleasman
Journal: Journal of Allergy and Clinical Immunology (2007)
Necrosis Occurring in the Neighbourhood of Joints or Other Important Parts: With Three Illustrative Cases
Authors: K. King
Journal: BMJ (1857)

ORIGINAL COMMUNICATION&.[BBITISH MBDICAL JOIKaNAL.clot, and then the artery was normal down to the sac.The sac had burst, and the parts immediately around it were in a gangrenous state, so that it was difficult to understand its exact relations.A lrge mass of fibrine rested on what ap- peared to have been the orifice of communication between the sac and the artery.The popliteal vein and its tributaries were plugged with softened fibrinous clots, and around the vessels were small scattered abscesses.
Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL)
Authors: M O'Hayre, M Niederst, J F Fecteau, V M Nguyen, T J Kipps, D Messmer, A C Newton, T M Handel
Journal: Leukemia (2012)

of the disease.Manageable toxicities and observed activity of elacytarabine CIV in the dose range 875 --2000 mg/m 2 per day may allow more flexible administration and dosing than for ara-C.AUC values for both substances and the increased initial half-life of ara-C after elacytarabine administration (2.0 h versus 0.1 --0.2 h), 12 indicate that treatment with elacytarabine provides plasma levels of both elacytarabine and ara-C in the concentration range associated with cytotoxicity that is, concentrations of ara-C that are effective in patients with AML. 13 This enables leukemia cells to maintain a high level of intracellular ara-C and consequently a high level of the active metabolite, ara-CTP.These findings are supported by in vitro data in tumor cells after treatment with elacytarabine. 8Elacytarabine administered at the recommended dose and schedule may provide a better exposure of leukemic cells to ara-CTP than that provided by ara-C.The acceptable safety profile and clinical anti-AML activity documented on this study support further evaluation of elacytarabine, particularly in patients with hENT1 deficiency. 14Fatty acid esterification of nucleoside analogs is a promising approach to circumvent clinically important mechanisms of resistance.
HIV infection rate among South African children found to be 5.6%
Authors: P. Sidley
Journal: BMJ (2002)

A new study on HIV infection and AIDS in South Africa has shown that children aged 2 to 14 years have an infection rate of 5.6%, leading to worries that South Africa's other epidemic—child abuse—is linked to the spread of HIV.

The Nelson Mandela/HSRC [Human Sciences Research Council] study of HIV and AIDS released last week draws for the first time on a representative sample of the local population including all ages and population groups. The most frequently used survey, done annually …
What Is the Role of Psychotherapy in the Treatment of Bipolar Disorder?
Authors: F. Colom, E. Vieta, A. Martínez, A. Jorquera, C. Gastó
Journal: Psychotherapy and Psychosomatics (1998)

&lt;b&gt;Background:&lt;/b&gt; The authors review and criticize the different roles developed by psychotherapy in the treatment of bipolar disorder, from psychodynamic conceptions to a biopsychosocial model. &lt;b&gt;Methods:&lt;/b&gt; The main computerized database (Medline, Current Contents, Psychological Abstracts) have been consulted, using the terms ‘psychotherapy’, ‘psychosocial’ and ‘bipolar disorder’ as key words. &lt;b&gt;Results:&lt;/b&gt; Psychoanalysis, psychoeducation, family therapy, cognitive-behavioral therapy and interpersonal therapy have been used in the treatment of bipolar patients. To date, none have established efficacy in controlled clinical trials regarding aspects such as hospitalization, recurrences or suicidal behavior, as medication alone does. Research on this issue usually undergoes methodological pitfalls. Nonetheless, the psychoeducative approach combined with several cognitive-behavioral techniques, either in group or individually, seem to be the most promising, focusing on information, treatment compliance, and illness management skills. &lt;b&gt;Conclusions:&lt;/b&gt; There is a need for systematic clinical research on psychotherapy applied to bipolar disorder in order to show its true usefulness. Psychoeducation should prove its positive influence on the course and outcome of bipolar disorder.
Prevention of Hepatitis B with the Hepatitis B Vaccine
Authors: Gregory A. Poland, Robert M. Jacobson
Journal: New England Journal of Medicine (2004)

A 25-year-old registered nurse comes for a visit to initiate prenatal care after receiving a positive result on a pregnancy test. On review of her vaccination status, she reports that she declined hepatitis B vaccination when it was offered by her current employer because she does not draw blood and thus does not consider herself at risk. Should she receive the vaccine? What are the current recommendations for hepatitis B vaccination?
Distinct Roles of BARD1 Isoforms in Mitosis: Full-Length BARD1 Mediates Aurora B Degradation, Cancer-Associated BARD1β Scaffolds Aurora B and BRCA2
Authors: Stephan Ryser, Eva Dizin, Charles Edward Jefford, Bénédicte Delaval, Sarantis Gagos, Agni Christodoulidou, Karl-Heinz Krause, Daniel Birnbaum, Irmgard Irminger-Finger
Journal: Cancer Research (2009)

Abstract The BRCA1-associated ring domain protein 1 (BARD1) interacts with BRCA1 via its RING finger domain. The BARD1-BRCA1 complex participates in DNA repair, cell cycle control, genomic stability, and mitotic spindle formation through its E3 ubiquitin ligase activity. Cancer cells express several BARD1 protein isoforms, including the RING finger–deficient variant BARD1β. Here, we show that BARD1 has BRCA1-dependent and BRCA1-independent functions in mitosis. BARD1, but not BRCA1, localizes to the midbody at telophase and cytokinesis, where it colocalizes with Aurora B. The 97-kDa full-length (FL) BARD1 coimmunoprecipates with BRCA1, but the 82-kDa BARD1β coimmunoprecipitates with Aurora B and BRCA2. We used selective small interfering RNAs to distinguish the functions of FL BARD1 and BARD1β. Depletion of FL BARD1 had only minor effects on cell growth and did not abolish midbody localization of BARD1 staining, but resulted in massive up-regulation of Aurora B. In contrast, suppression of FL BARD1 and BARD1β led to growth arrest and correlated with various mitotic defects and disappearance of midbody localization of BARD1 staining. Our data suggest a novel function of FL BARD1 in Aurora B ubiquitination and degradation, opposing a proproliferative function of BARD1β in scaffolding Aurora B and BRCA2. Thus, loss of FL BARD1 and up-regulation of Aurora B, as observed in cancer cells, can be explained by an imbalance of FL BARD1 and BARD1β. [Cancer Res 2009;69(3):1125–34]