tbuckley/cabot-search huggingface dataset:
Quitting Smoking Harder for Women
Authors: Brian Vastag
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatic disposition and biliary excretion of bilirubin and bilirubin glucuronides in intact rats. Differential processing of pigments derived from intra- and extrahepatic sources.
Authors: J M Crawford, B J Ransil, C S Potter, S V Westmoreland, J L Gollan
Journal: Journal of Clinical Investigation (1987)

Mechanisms for transport of bilirubin and its conjugates in hepatocytes have not been defined. We investigated the hepatic processing of bilirubin glucuronides and their precursors, and characterized the disposition of bile pigments arising from intraversus extrahepatic sources. Tracer doses of purified radiolabeled biliverdin, bilirubin, bilirubin monoglucuronide (BMG) or diglucuronide (BDG) were administered intravenously to intact normal or jaundiced homozygous Gunn rats. Rapid sequential analysis of radiolabeled BMG and BDG in bile revealed comparable excretion patterns following biliverdin and bilirubin injection, with BDG as the major pigment. Biliary excretion of radiolabeled conjugates from injected BMG was more rapid, with BMG predominating. Excretion of injected BDG in normal rats and BMG or BDG in Gunn rats was virtually identical to that of unaltered BMG in normal rats. Model independent analysis by deconvolution provided objective comparison of the disposition of radiolabeled pigments from the different sources. These findings indicate that bilirubin glucuronides formed in the liver from endogenous (hepatic) and exogenous (extrahepatic) sources of bilirubin follow a similar excretory pathway. BMG formed endogenously is converted preferentially to BDG, whereas circulating BMG is excreted predominantly unchanged. Exogenous conjugated bilirubins are excreted more rapidly than those generated intrahepatically, by a transcellular pathway that is largely independent of the conjugation system.
TCT-565 NOYA I: A Prospective Randomized Trial of the Biodegradable Polymer NOYA Sirolimus-Eluting Stent Compared with the Durable Polymer FIREBIRD 2 Sirolimus-Eluting Stent in Patients with Coronary Artery Disease: 9-Month Angiographic and 24-Month Clinical Results
Authors: Bo Xu, Kefei Dou, Yuejin Yang, Shuzheng Lu, Lefeng Wang, Haichang Wang, Zhanquan Li, Lei Wang, YunDai Chen, Yong Huo, Ajay Kirtane, Run-Lin Gao
Journal: Journal of the American College of Cardiology (2012)
Uninsured Worker Rate Rises
Authors: Brian Vastag
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physician to Student: The Crisis of Psychiatric Residency Training
Authors: JOHN M. SCANLAN
Journal: American Journal of Psychiatry (1972)

The author describes the experience of psychiatric residency training as a five-stage crisis in role transition involving role shock, orientation, trial and error, integration-consolidation, and recapitulation. He defines the crisis as a process involving both students and teachers. He hopes his formulation will provide a basis for anticipatory guidance and crisis-oriented interventions, thus maximizing the educational aspects of the training.
NYC Sex: How New York City Transformed Sex in America
Authors: J. H. Tanne
Journal: BMJ (2002)

The inaugural exhibition at the Museum of Sex, 233 Fifth Avenue, New York City www.museumofsex.com/ Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> My friend said that she was “sexed out,” in the way that Americans say “maxed out” when they've reached the limit on their credit cards. After two hours at the new Museum of Sex in New York we were tired. Sex, sex, sex—anyway, anyhow, multiple, on top, underneath, with friends, with men, with women, with three, with four, banned, censored, published, not published, in graceful 19th century prints and grainy 20th century stag films, or groaning blues—can become boring. This establishment is trying to be a serious museum. The entrance fee is … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Hypertensive Encephalopathy in Periodic Peritonitis With Amyloid Nephrosis
Authors: Muhlis A. Őzen
Journal: JAMA (1965)

ALTHOUGH the clinical picture of the periodic diseases has drawn the attention of various authors, they were first fully described by Reimann. 1 Later, Mamou and Cattan 2 demonstrated for the first time that in periodic peritonitis, amyloid nephrosis may develop after many years. Thus it was realized that the prognosis in periodic peritonitis is sometimes poor, whereas formerly it was considered favorable. In a family afflicted with periodic peritonitis, more than one member may have renal complications. 2-4   In this report we will describe hypertensive encephalopathy (HE) in a case of periodic peritonitis.  Report of a Case  The patient was an 8-year-old boy of Sephardi origin who was born in Istanbul, as were his parents and grandparents. Since he was 2 years old, he had had attacks of fever, severe abdominal and joint pains, occasional vomiting and diarrhea of one day's duration, after which he felt well.  On Jan
Endoscopic Treatment of a Perforated Duodenal Diverticulum
Authors: G. Eeckhout, J. Vanstiphout, I. Van Pottelbergh, P. Leyman, J. Vandervoort, M. De Man, P. Van der Spek, L. Lepoutre
Journal: Endoscopy (2000)

We describe a case of a perforated duodenal diverticulum, which was managed by a combined percutaneous and endoscopic approach. In combination with conservative treatment, this technique can be a challenging alternative to surgery.
Longevity and C282Y mutation for haemochromatosis: Data do not support conclusion
Authors: A. C Y Li
Journal: BMJ (2003)

EDITOR–Coppin et al say that the survival of people who were homozygous for the C282Y mutation among a cohort of French centenarians without treatment for haemochromatosis supports the view that the penetrance of this abnormal HFE gene in causing iron overload related morbidity is low.1 We are not clear that this conclusion can be reached with the data provided.

Most authorities regard …
The AIDS Net
Authors: Richard Peters, Robert Sikorski
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A lifetime of careful listening. A centennial retrospective on the work of William Carlos Williams (1883-1963)
Authors: J. Stone
Journal: JAMA (1983)

"A GOOD poet is someone who manages, in a lifetime of standing out in thunderstorms, to be struck by lightning five or six times; a dozen or two times and he is great." This definition of a poet, by the American poet-critic Randall Jarrell,<sup>1</sup>seems custom-made for William Carlos Williams. In a new and definitive biography of Williams, Mariani<sup>2</sup>has skillfully directed our attention to this compelling physician-writer, in good time for the centennial of his birth. William Carlos Williams (W.C.W.) has been called the "godfather... of nearly all the existent<i>avant garde poetry</i>."<sup>3</sup>It has been said that he is "the most important literary doctor since Chekhov" and that he "has attracted more followers in the last decade than have Yeats or Eliot."<sup>4</sup>On first examination, such encomiums may not seem that astonishing; others, such as Wallace Stevens, have combined writing with another career (in
Allelic Imbalance at <i>rs6983267</i> Suggests Selection of the Risk Allele in Somatic Colorectal Tumor Evolution
Authors: Sari Tuupanen, Iina Niittymäki, Kari Nousiainen, Sakari Vanharanta, Jukka-Pekka Mecklin, Kyösti Nuorva, Heikki Järvinen, Sampsa Hautaniemi, Auli Karhu, Lauri A. Aaltonen
Journal: Cancer Research (2008)

Abstract A common single nucleotide polymorphism (SNP), rs6983267, at 8q24.21 has recently been shown to associate with colorectal cancer (CRC). Three independent SNP association studies showed that rs6983267 contributes to CRC with odds ratios (OR) of 1.17 to 1.22. Here, we genotyped a population-based series of 1,042 patients with CRC and 1,012 healthy controls for rs6983267 and determined the contribution of SNP to CRC in Finland, using germ line DNA, as well as the respective cancer DNA in heterozygous patients. The comprehensive clinical data available from the 1,042 patients and their first-degree relatives enabled us to thoroughly examine the possible association of this variant with different clinical features. As expected, a significant association between the G allele of rs6983267 and CRC [OR, 1.22; 95% confidence interval (CI), 1.08–1.38; P = 0.0018] was found, confirming the previous observations. A trend towards association of the G allele with microsatellite-stable cancer (OR, 1.37; 95% CI, 1.02–1.85; P = 0.04) and family history of cancers other than CRC was seen (OR, 1.20; 95% CI, 1–1.43; P = 0.05). Four hundred and sixty-six GT heterozygotes identified in this study were analyzed for allelic imbalance at rs6983267 in the respective cancer DNA. One hundred and one tumors showed allelic imbalance (22%). The risk allele G was favored in 67 versus 34 tumors (P = 0.0007). This finding implicates that the underlying germ line genetic defect in 8q24.21 is a target in the somatic evolution of CRC. [Cancer Res 2008;68(1):14–7]
<i>MTHFR</i> 677 C&gt;T Polymorphism Reveals Functional Importance for 5-Methyltetrahydrofolate, Not Homocysteine, in Regulation of Vascular Redox State and Endothelial Function in Human Atherosclerosis
Authors: Charalambos Antoniades, Cheerag Shirodaria, Paul Leeson, Otto A. Baarholm, Tim Van-Assche, Colin Cunnington, Ravi Pillai, Chandi Ratnatunga, Dimitris Tousoulis, Christodoulos Stefanadis, Helga Refsum, Keith M. Channon
Journal: Circulation (2009)

Background— The role of circulating homocysteine as an atherosclerosis risk factor has recently been questioned. However, 5-methyl-tetrahydrofolate (5-MTHF), the circulating metabolite of folic acid participating in homocysteine metabolism, has direct effects on vascular function. We sought to distinguish the effects of plasma versus vascular tissue 5-MTHF and homocysteine on vascular redox and endothelial nitric oxide bioavailability in human vessels. Methods and Results— We used the methyl tetrahydrofolate reductase ( MTHFR ) gene polymorphism 677C&gt;T as a model of chronic exposure of the vascular wall to varying 5-MTHF levels in 218 patients undergoing coronary artery bypass graft surgery. Vascular superoxide, vascular 5-MTHF, and total homocysteine were determined in saphenous veins and internal mammary arteries obtained during surgery. Nitric oxide bioavailability was evaluated by organ bath studies on saphenous vein rings. MTHFR genotype was a determinant of vascular 5-MTHF (not vascular homocysteine). Both MTHFR genotype and vascular 5-MTHF were associated with vascular nitric oxide bioavailability and superoxide generated by uncoupled endothelial nitric oxide synthase. In contrast, vascular homocysteine was associated only with NADPH-stimulated superoxide. Conclusions— Genetic polymorphism 677 C&gt;T on MTHFR affects vascular 5-MTHF (but not homocysteine) and can be used as a model to distinguish the chronic effects of vascular 5-MTHF from homocysteine on vascular wall. Vascular 5-MTHF, rather than plasma or vascular homocysteine, is a key regulator of endothelial nitric oxide synthase coupling and nitric oxide bioavailability in human vessels, suggesting that plasma homocysteine is an indirect marker of 5-MTHF rather than a primary regulator of endothelial function.
Liposome-bound prostaglandin E1 often prevents cyclic flow variations in stenosed and endothelium-injured canine coronary arteries.
Authors: J T Willerson, S K Yao, J McNatt, K Cui, H V Anderson, C Swensen, M Ostro, L M Buja
Journal: Circulation (1994)

BACKGROUND Prostaglandin E1 is a potent vasodilator with anti-inflammatory and antiplatelet effects. We tested the hypothesis that prostaglandin E1 attenuates or prevents platelet aggregation-associated cyclic flow variations (CFVs) in severely stenosed and endothelium-injured coronary arteries. METHODS AND RESULTS We induced CFVs in 21 dogs by placing an external constrictor around the left anterior descending coronary artery at the site where the endothelium had been mechanically injured. The blood flow velocity in the artery was monitored by a pulsed Doppler flow probe. Sixty minutes after CFVs were established, liposome-bound prostaglandin E1, a stable formulation, was administered intravenously to 12 dogs at incremental doses of 0.25, 0.5, 1, and 2 micrograms/kg body wt; it abolished CFVs in 8 of the 12 dogs (67%). After CFVs were eliminated, epinephrine was infused intravenously, and at a dose of 6.6 +/- 1.6 micrograms/min, it restored CFVs in 7 of 7 dogs. Control dogs (n = 9) were treated with free prostaglandin E1, which did not abolish CFVs in any dog. CONCLUSIONS Liposome-bound but not free prostaglandin E1 effectively diminishes CFVs in severely stenosed and endothelium-injured canine coronary arteries.
Initiating End-of-Life Discussions With Seriously Ill Patients
Authors: Timothy E. Quill
Journal: JAMA (2000)

Discussions about end-of-life issues are difficult for clinicians to initiate. Patients, their families, and clinicians frequently collude to avoid mentioning death or dying, even when the patient's suffering is severe and prognosis is poor. In addition to determining from observational research when and where communication problems exist, much can be learned from in-depth discussions with patients, family members, and physicians who are facing these issues together. Using segments of interviews with a patient with advanced pulmonary fibrosis, his son, and his primary care physician, this article illustrates and explores some of these communication issues, including the who, what, when, why, and how of end-of-life discussions. Studies from the medical literature, the patient's and physician's particular experience together, and the author's clinical experience provide practical insights into how to address these issues. Initiating end-of-life discussions earlier and more systematically could allow patients to make more informed choices, achieve better palliation of symptoms, and have more opportunity to work on issues of life closure.
Cutaneous adverse effects in patients treated with the multitargeted kinase inhibitors sorafenib and sunitinib
Authors: W.J. Lee, J.L. Lee, S.E. Chang, M.W. Lee, Y.K. Kang, J.H. Choi, K.C. Moon, J.K. Koh
Journal: British Journal of Dermatology (2009)

Summary Background The multitargeted kinase inhibitors sorafenib and sunitinib have improved treatment of solid tumours including renal cell carcinoma and hepatocellular carcinoma by offering better clinical responses. However, sorafenib and sunitinib are commonly associated with cutaneous toxicity. Objectives We conducted this study to make a clinical assessment of the cutaneous toxicities induced by the oral multitargeted kinase inhibitors sorafenib and sunitinib. Methods Retrospectively, we reviewed medical records of patients receiving multitargeted kinase inhibitors, including 109 patients on sorafenib for the treatment of renal cell carcinoma or hepatocellular carcinoma and 119 patients receiving sunitinib for treatment of renal cell carcinoma or a gastrointestinal stromal tumour. Clinical data on cutaneous toxicities were collated. We describe the incidences and intensities of toxicities, and analyse the data statistically. Results The most common cutaneous toxicity was hand-and-foot skin reaction (HFSR). Other cutaneous toxicities included alopecia, stomatitis, skin discoloration (hair or face), subungual splinter haemorrhage, facial swelling, facial erythema and xerosis. HFSR and severe stomatitis required therapy modifications to relieve symptoms, but other cutaneous toxicities did not affect treatment course. HFSR was observed in 48% of patients treated with sorafenib and 36% of those treated with sunitinib. Median time to onset was 18·4 days in patients receiving sorafenib and 32·4 days in those receiving sunitinib. HFSR and stomatitis were early symptoms compared with other cutaneous toxicities. Patients with severe HFSR were likely to develop the symptoms at early phases of therapy. A significant correlation between the severity of HFSR and development of alopecia and stomatitis was found. Conclusions Multitargeted kinase inhibitors are associated with a significant risk of various cutaneous adverse events. HFSR is the commonest and most serious cutaneous toxicity in patients treated with these drugs.
Treatment of psoriasis with topical selenium sulphide
Authors: E. Borglund, A. Enhamre
Journal: British Journal of Dermatology (1987)

Journal Article Treatment of psoriasis with topical selenium sulphide Get access E. Borglund, E. Borglund Department of Dermatology, Karolinska Hospital, S‐104 OI Stockholm, Sweden Search for other works by this author on: Oxford Academic Google Scholar A. Enhamre A. Enhamre Department of Dermatology, Karolinska Hospital, S‐104 OI Stockholm, Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue 5, 1 November 1987, Pages 665–666, https://doi.org/10.1111/j.1365-2133.1987.tb07503.x Published: 01 November 1987
Regarding Medical Education Today
Authors: Harold Jeghers
Journal: New England Journal of Medicine (1958)

A REMARKABLE ferment, indicative of much future good, pervades the entire structure of medical education, including the undergraduate phase (also called basic medical education), intern, resident and fellowship training (commonly called graduate education) and the postgraduate phase (also called continuation medical education). The technics used in these areas of medical education are increasingly being modified and subjected to scientific appraisal similar to a clinical-research approach.Applying a critical evaluation to teaching technics has been my fundamental interest for some twenty years in three different medical institutions, including participation in the development of a new school in my present position. During . . .
Does knee pain in the community behave like a regional pain syndrome? Prospective cohort study of incidence and persistence
Authors: K T Palmer, I Reading, M Calnan, C Linaker, D Coggon
Journal: Annals of the Rheumatic Diseases (2006)

<b>Objectives:</b> To investigate whether knee pain in the community behaves like a regional pain syndrome, determined by its association with mental health, self-rated health (SRH) and beliefs about prognosis. <b>Methods:</b> An 18-month postal follow-up was conducted in 1798 working-aged subjects, sampled from the community. At baseline questions were asked about pain in the knee lasting ⩾1 day in the previous 12 months, mental health (Short-Form 36), somatising tendency (elements of the Brief Symptom Inventory), SRH and concern about 12-month prognosis. At follow-up we asked about knee pain during the last 4 weeks, and whether it had been present for ⩾14 days or prescription-treated. Associations with incidence and persistence were explored using logistic regression. <b>Results:</b> The 1256 participants (70% response) comprised 468 with knee pain at baseline and 788 without. Among the former, 49% had persistent knee pain at follow-up, while among the latter, 15% reported new symptoms. Incident prescription-treated knee pain was strongly associated with all of the mental health variables and with SRH. The odds of knee pain persisting were significantly raised in the least versus most favourable bands of somatising tendency and SRH, and persistence was also significantly more common among those who at baseline were concerned that they would still have a problem in 12 months. <b>Conclusions:</b> Our observations support the hypothesis that knee pain in the community shares risk factors in common with other non-specific regional pain syndromes.
Paget Sarcoma of the Pelvic Bone With Widespread Metastatic Disease on Radiography, CT, MRI, and 18F-FDG PET/CT With Pathologic Correlation
Authors: Michael A. Davis, Luke R. Scalcione, Lana H. Gimber, Rebecca B. Thompson, Ryan J. Avery, Mihra S. Taljanovic
Journal: Clinical Nuclear Medicine (2014)

We report a case of Paget sarcoma of the left superior pubic ramus and disseminated metastatic disease in a 70-year-old man. Paget disease of the left hemipelvis with malignant degeneration in the region of the left superior pubic ramus was initially diagnosed on radiographs. Subsequent CT, MRI, PET/CT imaging, and CT-guided biopsy confirmed the diagnosis and showed extensive left-sided pelvic and abdominal lymphadenopathy with widespread metastatic disease to liver, spleen, and lungs.