tbuckley/cabot-search huggingface dataset:
Chairman's Address of the Section on Neurology.
Authors: C. H. Hughes
Journal: JAMA (1898)

St. Louis, Mo., Oct. 25, 1888. <h3>To the Editor:</h3> —When I began to get my address ready for my quarterly in order to place it for future reference, I sent galley proof to the secretary of the Section. The paper has been printed, but three months after the meeting at Denver. I did as I have done heretofore, having no desire to antedate theJournal, but being absent over three months with a sick wife, did not know that you had not published it. You can do as you please about abstract, but I do not think Section work will appear as complete as theAssociationwould desire for future reference with only abstracts of president's addresses. If you print only as an abstract kindly put this in your correspondence column, as I wish to go on record with the explanation and gentle protest, my gentle and amiable friend. I
Scintigraphic Findings in Chronic Actinomycosis Osteomyelitis and Associated Soft Tissue Infection
Authors: FRANK M. GRUND, STEPHEN L. EWING, REX B. SHAFER
Journal: Clinical Nuclear Medicine (1986)

Scintigraphic findings are reported in a patient with actinomycosis osteomyelitis and soft tissue infection to illustrate the need to understand the mechanism of localization of the radiopharmaceutical to accurately assess the clinical pathology.
Anti‐IgG Antibodies and Antinuclear Antibodies in Allergic Patients
Authors: Else‐Marie Egeskjold, H. Permins, Inge Nielsens, H. Juul Sørensen, O. ØTerralle, H. E. Kallerup
Journal: Allergy (1981)

With an indirect immunofluorescencc technique 77 % of 96 patients with type I allergy and 40% of 20 patients with intrinsic bronchial asthma showed positive reactions for IgG ami‐IgG antibodies in serum. They were present partly in an aggregated state not directly detectable before treatment with dithiothreitol. The aggregates could be removed by precipitation with polyethylene glycol. The IgG ami‐IgG in hyposensitized patients were directed against both F(ab′) 2 and Fe fragments of rabbit IgG. Thirty of the type I allergic patients were examined once during hyposensitization as well. Before treatment 87% and IgG anti‐IgG (titres 9–72). After ≥ 13 months of treatment 100% were positive (titres 35–288), Fight patterns were also examined after hyposensitzation had been discontinued for at least 12 months. The titres of IgG ami‐IgG had then reverted lo the levels obtained before hyposensitization. Of 116 controls matched for sex and age, 79r had IgG ami‐IgG anybodies, is suggested that the production of IgG anti‐IgG may be stimulated by the presence of immune complexes and that purity, amount and/or combination of allergens administered during hyposensitization may influence the production of anti‐JgG antibodies. Neither IgK anti‐IgG nor antinuclear antibodies seem to be of particular significance in allergic patients.
Straight Back Syndrome?
Authors: M. S. RAWLINGS
Journal: Annals of Internal Medicine (1971)

Letters and Comments1 February 1971Straight Back Syndrome?M. S. RAWLINGS, M.D.M. S. RAWLINGS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-2-300_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I notice in the August 1970 issue of the ANNALS(p. 335, an editorial note) a comment by Dr. Morton E. Tavel that careful study of the "straight back syndrome" suggests a fortuitous combination of skeletal deformities and normal variant heart sounds. All of this, of course, is exactly why the condition is called a "syndrome" rather than a disease. The only error in the description is the use of the word "fortuitous." The incidence of these abnormal sounds (or false heart enlargement) is so unusually high when a straight back is present (or pectus excavatum, for... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Diagnostic Center 2410 McCallie Ave. Chattanooga, Tenn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1971Volume 74, Issue 2Page: 300-300KeywordsHeartLongitudinal studies Issue Published: 1 February 1971 PDF DownloadLoading ...
Editorial: Osteoporosis among women who smoke cigarettes
Authors: H. H. Hussey
Journal: JAMA (1976)

In the current issue of<i>Archives of Internal Medicine</i>(136: 298-304, 1976), Daniell observes that progressive osteoporosis is apparently universal among postmenopausal women and lists factors that have been considered to play a contributory role. Among the more common factors are small constitutional size, a genetic predisposition including white ancestry, deficiencies of calcium and sex hormones, inactivity, and aging. Less frequent factors are thyrotoxicosis, malabsorption syndromes, the postgastrectomy state, collagen diseases, sustained corticosteroid excess, alcoholism, hyperthyroidism, and chronic uremia. In an earlier article,<sup>1</sup>Daniell noted that middle-aged men and women with symptomatic osteoporosis were almost exclusively heavy cigarette smokers. This observation led him to pursue two further studies in women: the incidence of vertebral compression fractures and the degree of bone density as determined by roentgenographic examination of the second metacarpal bone. Accordingly, the author examined the hospital records of women between the ages of 40 and 70 years
Rubella-neutralizing and haemagglutinin-inhibiting antibodies in children of different ages
Authors: T. Brown, M. H. Hambling, B. M. Ansari
Journal: BMJ (1969)

Rubella neutralization and haemagglutinin-inhibition tests were used to determine the incidence of rubella antibodies in the sera of 235 children and adolescents aged 1 month to 20 years. The tests showed good agreement in the detection of rubella antibodies resulting from acute infection. Maternal antibodies became undetectable within six months after birth. The proportion of children possessing rubella antibodies was found to be about 23% by the age of 5 years, rising sharply to 80% in the 6–12 years age group and 83% in the 13–20 years age group. Results indicate that the incidence of rubella infection may be higher in females than in males. The correlation between statements concerning a past history of rubella and immune status was poor, particularly in the older age groups. Any policy for vaccination against rubella must take into account the difficulties of identifying nonimmune persons in a large population.
Bubble Stability Test Compared with Lecithin Assay in Prediction of Respiratory Distress Syndrome
Authors: S. G. Bhagwanani, D. Fahmy, A. C. Turnbull
Journal: BMJ (1973)

A simple test for surfactant, utilizing bubble stability in ethanol, was performed in 106 samples of amniotic fluid obtained from 94 patients. Of these patients 80 delivered within 48 hours of the collection of the sample. The results were compared with the lecithin concentration in the same amniotic fluid samples and with the quality of respiration in the neonate. The test was "positive," indicating fetal pulmonary maturity, in 37 cases and none of these infants developed respiratory distress syndrome (R.D.S.). In only one of these cases, however, was gestation less than 37 weeks. The test was "intermediate" or "negative" in 43 cases but in 35 of these infants respiration at birth was perfectly normal.Performed by the method described by its originators, this simple test gives too many false negative results to be of value in routine clinical practice, although a positive result is helpful. The concept of the test is ingenious, however, and further developments may be expected.
The magical number 4 = 7: Span theory on capacity limitations
Authors: Bruce L. Bachelder
Journal: Behavioral and Brain Sciences (2001)

According to span theory, a behavioral theory of the magical numbers, Cowan's 4 and Miller's 7 are simply two different points on the same ogive describing the relation between performance and span load, a fundamental task characteristic. Span theory explains the magical numbers in terms of a unitary limited span ability, a mathematical abstraction from that ogive.
Inherited Elevation of Alkaline Phosphatase Activity in the Absence of Disease
Authors: Jeffrey W. Wilson
Journal: New England Journal of Medicine (1979)

SERUM alkaline phosphatase activity was markedly elevated in a young man without an apparent underlying disorder. The unexpected finding of an elevated alkaline phosphatase level in the patient's father prompted an investigation of other family members.Subjects and MethodsA 15-year-old boy, 160 cm tall and weighing 41 kg, complained of abdominal pain. The results of physical examination and laboratory studies, including complete blood count, urinalysis and analysis of blood components, were normal, except for a serum alkaline phosphatase level greater than 1050 units per liter (normal, 30 to 85) (Bessey-Lowry-Brock method1).Subsequent evaluation revealed normal values for liver . . .
Plasma Inhibitors of the Components of the Fibrinolytic Pathway in Man
Authors: Alan D. Schreiber, Allen P. Kaplan, K. Frank Austen
Journal: Journal of Clinical Investigation (1973)

The effect of highly purified inhibitor of the first component of complement (CāINH), alpha2 macroglobulin (alpha2M), and alpha1 antitrypsin on the components of the fibrinolytic pathway in human plasma has been examined. CāINH was the only factor active upon the Hageman factor fragments functioning at the initial step of the fibrinolytic pathway, alpha2M was the only factor active against the plasminogen activator and the most active inhibitor of plasmin. The inhibition of plasmin by alpha2M appeared stoichiometric with one molecule of alpha2M inhibiting two molecules of plasmin. All three plasma inhibitors were active against plasmin.
Abstract 1669: Discovery of nasopharyngeal carcinoma susceptible variants from whole genome imputation of genome-wide association study
Authors: Wen-Hui Su, Kai-Ping Chang, Yu-Sun Chang
Journal: Cancer Research (2012)

Abstract Nasopharyngeal carcinoma (NPC) is a multifactorial malignancy closely associated with genetic factors and Epstein-Barr virus (EBV) infection. To identify the common genetic variants linked to NPC susceptibility, we have conducted a genome-wide association study (GWAS) within the Taiwanese population, analyzing 480,365 single-nucleotide polymorphisms (SNPs). In this study, only 12 SNPs that can pass the statistical criteria for GWAS were reported and all of them located within chromosome 6 MHC region. However, those 12 SNPs can only explain a small fraction of genetic risk. The vase majority of the genetic risks remain undiscovered. Additional analytical procedures are vary likely to provide valuable information for NPC susceptibility. By utilizing 1000 genome data, we successfully expend SNP number to 37,512,779 SNPs. After removed SNPs with low quality (info &amp;lt;0.5) and no heterozygosity, we discovered additional 57,212 SNPs from whole genome imputation including 3,751 SNPs with P values &amp;lt;0.05. SNPs located in chromosome 1, 2, 3, 8, 15, 17 were selected for further validation. This work taking advantage of current genome sequencing database and significantly expand the range of associated SNPs that can also increase the chance to discover true association signals. Following functional investigation and experimental application of these findings are expected to produce new advances in the prevention and treatment of NPC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1669. doi:1538-7445.AM2012-1669
Effects of Endothelin A Receptor Blockade on Endothelial Function in Patients With Chronic Heart Failure
Authors: Rudolf Berger, Brigitte Stanek, Martin Hülsmann, Bernhard Frey, Sandra Heher, Richard Pacher, Thomas Neunteufl
Journal: Circulation (2001)

Background —Chronic heart failure (CHF) is associated with impaired endothelium-dependent vasodilation and increased basal vascular tone due, in part, to elevated endothelin-1 plasma levels. In the present study, we investigated whether a reduction of vascular tone using an endothelin A receptor blocker attenuates the impairment of endothelium-dependent, flow-mediated vasodilation (FMD). Methods and Results —Twenty-one patients with CHF randomly received either the endothelin A receptor blocker LU 135252 (30 mg/d, n=7; 300 mg/d, n=7) or a placebo (n=7). Using high-resolution ultrasound, FMD and endothelium-independent, nitroglycerin-induced dilation of the brachial artery were assessed at baseline in the 21 patients with CHF and in 11 controls and after 3 weeks treatment in the 21 patients with CHF. FMD at baseline was impaired in all 21 patients with CHF (3.2±2%) when compared with the 11 controls (9.7±4.9%; P =0.0005). In comparison with baseline, FMD significantly improved after 3 weeks of treatment with LU 135252 in all 14 patients receiving it (from 3.0±2.0% to 4.9±2.9%; P =0.04), but FMD remained unchanged with placebo. Subgroup analysis, according to different dosages, revealed a significant increase of FMD compared with baseline (from 2.4±1.5% to 5.5±2.4%; P =0.03) in the patients treated with the low-dose (30 mg/d), whereas a high dose of 300 mg/d failed to increase FMD significantly. Improvement in the high-dose group, however, may have been masked by reduced vasodilator capacity due to a significant increase in vessel size (from 4.8±0.4 to 5.1±0.7 mm; P =0.03). Conclusions —These results suggest that endothelin A receptor blockade improves FMD in CHF patients.
Public satisfaction with hospital emergency departments drops in Britain
Authors: J. Wise
Journal: BMJ (2014)

Public satisfaction with hospital emergency departments is at its lowest level since 2008, the latest British Social Attitudes survey has shown.1 However, satisfaction with how the NHS is run was unchanged at 60%. Before 2004 the public’s overall satisfaction with the NHS fluctuated between 34% and 46%, and it then rose steadily to an all time high of 70% in 2010, reflecting higher NHS funding and shorter waiting times. But in 2011 satisfaction dropped sharply to …
Primary Prevention Implantable Cardioverter-Defibrillators and Survival in Older Women
Authors: Emily P. Zeitler, Anne S. Hellkamp, Gregg C. Fonarow, Stephen C. Hammill, Lesley H. Curtis, Adrian F. Hernandez, Hussein R. Al-Khalidi, Jeptha P. Curtis, Paul A. Heidenreich, Kevin J. Anstrom, Eric D. Peterson, Daniel B. Mark, Bradley G. Hammill, Gillian D. Sanders, Sana M. Al-Khatib
Journal: JACC Heart Failure (2014)
VERTEBRAL SURGERY WITH REPORT OF THREE CASES, AND A NEW METHOD OF OPERATING IN THE DORSAL REGION.Read before the Illinois State Medical Society, 1891.
Authors: F. C. SCHAEFER
Journal: JAMA (1891)

Operations upon the spine are called for in cases of: 1. Traumatism; 2, Neoplasms; 3, Caries. It is my desire to occupy a few moments of your time by briefly reporting three cases of the third class, and giving the result of operations upon the cadaver, done with a view of ascertaining how to attack the diseased bodies of the vertebræ with the least degree of danger to, or disturbance of, the spinal cord in the dorsal region. Among the most troublesome cases the surgeon has to contend with, we may safely place caries of the vertebræ, and especially the tubercular variety. During the past two years it has fallen to my lot to treat a number of these, three of which I will report at the present time as germane to the topic, viz.: "Operations upon the spine for caries of the bodies of the vertebræ." <i>History. Case 1.</i>—Miss
Virus-free blood?
Authors: H B Lewis
Journal: BMJ (1971)

portant to exclude inhalation of the object.A 4-year-old boy was brought to this department recently thought to have ingested a foreign body, "ingestion" being associated with a short bout of coughing.Clinically he showed no adverse effects and he was not x-rayed.Three days later his mother brought him back stating that he seemed unwell in himself and appeared to be breathless.X-rays showed a foreign body lodged in the right main bronchus.May we therefore suggest the following indications for x-raying children suspected of ingesting foreign bodies when presenting
NTG-enhanced coronary MRA: improved SNR and vasodilation time course
Authors: Masahiro Terashima, Brian G. Keeffe, Eric J. Putz, Phillip C. Yang, Erasmo de la Pena-Almaguer, Bob S. Hu, Dwight G. Nishimura, Craig H. Meyer, Michael V. McConnell
Journal: Journal of the American College of Cardiology (2002)
Life Insurance for the Young Cardiovascular Patient
Authors: David Baum
Journal: JAMA (1963)

LIFE INSURANCE has been difficult to obtain for the young individual who has had a cardiovascular complaint. In the not too distant past, the patient with an innocent heart murmur often was not reliably differentiated from the child with rheumatic heart disease or a congenital cardiovascular defect because of the inadequacy of diagnostic techniques. In addition, prior to 1939, there was no method of complete correction of a cardiovascular defect. 1 As a result, life insurance companies were reluctant to insure these patients. 2   The accuracy of diagnosis and the effectiveness of therapy of cardiovascular disease have undergone remarkable changes in the past 2 decades. Facilities are now available which permit even complex abnormalities to be diagnosed with precision. Furthermore, advances in cardiovascular surgery have, in many cases, improved the prognosis to such an extent that these patients can look forward to living normal lives. For these reasons, it seemed
Healed Dissecting Aneurysm of the Aorta Erroneously Diagnosed Paramediastinal Effusion; Death Following Attempted Aspiration
Authors: J. CHANDLER SMITH, SALVATORE M. SANCETTA
Journal: Circulation (1950)

Approximately 1 per cent of dissecting aneurysms of the aorta develop re-entry tears and heal, forming the so-called "double-barrelled" aorta which is compatible with a variable period of survival. Occasionally a case is found wherein the dissection has remained limited to the media, healing without evidence of intimal tears. We describe such a case, so rare as to constitute a medical curiosity.
Unbalanced Deoxyribonucleotide Synthesis Caused by Methotrexate
Authors: A. V. Hoffbrand, E. Tripp
Journal: BMJ (1972)

The effect of methotrexate on the free intracellular pools of thymidylate triphosphate (dTTP) and deoxyadenosine triphosphate (dATP) in normal human phytohaemagglutinin-transformed lymphocytes has been studied. Methotrexate caused a fall in the dTTP pool ranging from 38% to 88% and a rise in the dATP pool ranging from 24% to 185%.A rise in the free intracellular pool of dATP is thought to inhibit both rubonucleotide reduction and polynucleotide ligase, an enzyme concerned in DNA synthesis and repair. The hypothesis is suggested here that folate deficiency per se, as well as a functional folate deficiency induced by methotrexate may cause reduced DNA synthesis, megaloblastic changes, and chromosome abnormalities by producing a rise in the free intracellular pool of dATP as well as by causing a fall in free intracellular dTTP.
Letter: Sexual dysfunction due to methyldopa.
Authors: R J Newman, H R Salerno
Journal: BMJ (1974)

would like to add one more consideration.I have recently observed two cases of post- anaesthetic jaundice in which halothane was employed.On careful investigation these were proved to be due to Gilbert's disease (congenital hyperbilirubinaemia). Starvation precipitates icterus in these cases, causing a raised plasma unconjugated bilirubin level, usually within 48 hours.The incidence of Gilbert's disease may be as high as 5% and it should therefore be a consideration in the differential diagnosis of cases of post- anaesthetic jaundice.-Iam, etc.,
The Excess Mortality of Black Adults in the United States
Authors: J. Paul Leigh
Journal: JAMA (1990)

<h3>To the Editor.—</h3> As a social scientist, I rejoiced when I read the study by Otten et al,<sup>1</sup>which suggested that socioeconomic status accounts for more than one third of the mortality differential between blacks and whites. From a social science perspective, however, their
Anti-HCV-negattve chronic non-A, non-B hepatitis: Seronegative Hepatitis C or “non-A, non-B, non-C” Hepatitis?
Authors: J. Havelka, G. Zala, H.J.Joller Jemelka, A. Wicki, J.A. Garson, B. Meier, M. Schmid, H. Bühler
Journal: Journal of Hepatology (1991)
The Role of the Medical Profession in Physician Discipline
Authors: F. Douglas Scutchfield
Journal: JAMA (1998)

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Admissions to intensive care peak in December
Authors: R. Dobson
Journal: BMJ (2002)

Admissions to intensive care units in England peak in December and are at their lowest in February, latest figures have shown.

Admission rates in December are 30% higher than in the quietest month, said the researchers, who analysed data on 16 355 critically ill patients admitted to five NHS critical care units during an eight year period. They also found that there has been an increase in admissions equivalent to an annual rise of 6.6%.

In a report of the study ( Anaesthesia 2001;56:1136-40), the team said that a summer peak …
DC-based cancer vaccines
Authors: Eli Gilboa
Journal: Journal of Clinical Investigation (2007)

Because of the large preexisting antigenic load and immunosuppressive environment within a tumor, inducing therapeutically useful antitumor immunity in cancer patients requires the development of powerful vaccination protocols. An approach gaining increasing popularity in the tumor vaccine field is to immunize cancer patients with their own DCs loaded ex vivo with tumor antigens. The underlying premise of this approach is that the efficiency and control over the vaccination process provided by ex vivo manipulation of the DCs generates an optimally potent APC and a superior method for stimulating antitumor immunity in vivo compared with the more conventional direct vaccination methods, offsetting the added cost and complexity associated with this form of customized cell therapy.
TCT-638 Five-year Clinical Outcomes of Drug Eluting Stents Versus Bare Metal Stents in Patients With Large Vessel and Single Coronary Lesion
Authors: Kyuhwan Park, Chan-Hee Lee, Yoon Jung Choi, Tae Hun Kwon, Kanguni Choi, Jang Won Son, Sang-Hee Lee, Ung Kim, Jong Seon Park, Dong-Gu Shin, Young-Jo Kim, Jeong-Hwan Cho, Sang Wook Kang, Yoon-Kyung Cho, Hyungseop Kim, Chang-Wook Nam, Seung-Ho Hur, Kwon-Bae Kim, Dong-Kie Kim, Sang-Hoon Seol, Tae-Hyun Yang
Journal: Journal of the American College of Cardiology (2014)