tbuckley/cabot-search huggingface dataset:
AB0093 Association of cd247 polymorphisms with rheumatoid arthritis: a replication study and a meta-analysis
Authors: M. Teruel, C. McKinney, A. Balsa, D. Pascual-Salcedo, L. Rodriguez-Rodriguez, A. M. Ortiz, C. Gómez-Vaquero, M. A. González-Gay, M. Smith, T. Witte, T. R. Merriman, B. A. Lie, J. Martin
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The T-cell receptor T3 zeta chain (<i>CD3</i>ζ), also called CD247, is essential for assembly, surface expression and signaling cascade of the T-cell receptor-CD3 complex (TCR/CD3 complex). Abnormalities in this pathway can result in T-cell dysfunction and development of autoimmune disorders [1]. Regarding this, previous reports have demonstrated an association of <i>CD247</i> variants with systemic lupus erythematosus [2, 3] and systemic sclerosis [4, 5]. In the case of rheumatoid arthritis (RA), one meta-GWAS found no association between <i>CD247</i> gene and RA at a genome-wide level of significance [6], however, a more recent meta-analysis of GWAS on RA and celiac disease (CeD) identified <i>CD247</i> gene as a new susceptibility locus for RA [7]. <h3>Objectives</h3> In order to better clarify the role of this gene in RA susceptibility, we aimed to analyze <i>CD247</i> gene variants previously associated with other autoimmune diseases (rs1052237, rs2056626 and rs864537) in a large independent European Caucasian population. <h3>Results</h3> However, no evidence of association was found for these three <i>CD247</i> SNPs with RA and with the anti-cyclic citrullinated polypeptide (anti-CCP) status. We performed a meta-analysis including GWAS data for the rs864537 from previously published data, reveling an overall genome-wide significant association between rs864537 and RA with anti-CCP (OR 0.90 [0.87 to 0.93], P<sub>overall</sub>= 2.1 x 10<sup>-10</sup>). <h3>Conclusions</h3> Our results described for first time at GWAS-level the association of this <i>CD247</i> variant and RA risk <h3>References</h3> Takeuchi T <i>et al</i>. <i>Ann Rheum Dis</i>. 2012; 71:i78-i81. Gorman CL <i>et al</i>. <i>J Immunol</i>. 2008; 180: 1060-70. Warchol T <i>et al</i>. <i>Tissue Antigens</i>. 2009; 74:68-72. Dieude P <i>et al</i>. <i>Ann Rheum Dis</i>. 2011;70:1695-6. Radstake TR <i>et al</i>. <i>Nat Genet</i>. 2010; 42:426-9. Stahl EA <i>et al</i>. <i>Nat Genet</i>. 2010; 42:508-14. Zhernakova A <i>et al</i>. <i>PLoS Genet</i>. 2011; 7:e1002004. <h3>Acknowledgements</h3> This work was supported by two Spanish grants from RETICS Program, RD08/0075 (RIER) from Instituto de Salud Carlos III (ISCIII), within the VI PN de I+D+i 2008-2011 (FEDER) and also by grants from the European IMI BTCure Program. MT was supported by Spanish Ministry of Science through the program Juan de la Cierva (JCI-2010-08227). <h3>Disclosure of Interest</h3> None Declared
Drugs and Deformities
Authors: Benjamin W. Carey
Journal: JAMA (1962)

<h3>To the Editor:—</h3> Because of the current atmosphere of heightened sensitivity to the use of drugs in pregnant women, I wish to comment on a communication in the Aug. 11, 1962, issue of the<i>British Medical Journal</i>which purports to link administration of tetracycline during pregnancy to the birth of an infant with malformed hands. The authors, Drs. M. P. Carter and F. Wilson,<sup>1</sup>speculate that tetracycline, which is known to deposit in bones undergoing ossification, may have been responsible for the observed malformation, syndactyly, and absence of the fourth and fifth metacarpals and phalanges. The tetracycline was given to the mother for 3 days starting on the 33rd day of pregnancy for the treatment of acute bronchitis complicated with pleurisy. At that point in time, according to Gardner<sup>2</sup>and Potter,<sup>3</sup>no centers of ossification can be demonstrated by any method in the metacarpals or phalanges prior
Charities welcome 50m interim cancer drugs fund
Authors: J. Wise
Journal: BMJ (2010)

The Department of Health in England has made an extra £50m (€60m; $80m) available to fund expensive anticancer drugs that have not been approved by the National Institute for Health and Clinical Excellence (NICE). The move has been welcomed by cancer charities but criticised by a leading health economist as unfair and as undermining NICE’s role.

The £50m is interim funding to be used in the six months until the government’s new Cancer Drugs Fund starts in April 2011. The exact amount of money available for the fund will not be known until after the comprehensive spending review but is expected to be £200m. A full public consultation on how the fund will work is to take place this autumn.

The government says the funding will help doctors and patients access drugs that NICE has not been able to appraise positively because of concerns about cost effectiveness or where it has not issued guidance or been unable to issue guidance.

The health secretary, Andrew Lansley, first announced the interim …
Changes in the dynamics of the excess mortality rate in chronic phase-chronic myeloid leukemia over 1990-2007: a population study
Authors: Selim Corm, Laurent Roche, Jean-Baptiste Micol, Valérie Coiteux, Nadine Bossard, Franck-Emmanuel Nicolini, Jean Iwaz, Claude Preudhomme, Catherine Roche-Lestienne, Thierry Facon, Laurent Remontet
Journal: Blood (2011)
Bad medicine: adult attention-deficit/hyperactivity disorder
Authors: Des Spence
Journal: BMJ (2011)

US medicine is a paradox—the best and the worst of medicine. US psychiatry engages in widespread polypharmacy and willingly medicates children, actions that I profoundly fail to understand. How did US psychiatry get to this point⇑?

My theory runs like this. The Diagnostic and Statistical Manual of Mental Disorders (DSM) defines a condition. But this is descriptive, almost literary narrative, not robust science. This description is loose, so loose that it always includes traits common to us all. Psychiatry has thus become pharma’s goldmine, with a simple business plan. Seek a small group of …
Antibody response to melanoma helper-peptide vaccine correlates with survival
Authors: Walter C Olson, Caroline M Reed, Craig L Slingluff
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts A melanoma vaccine comprising 6 peptides presented by Class II MHC molecules was safe and induced CD4+ T cell responses in 81% of recipients. Circulating CD4+ T cell responses to these 6 melanoma helper peptides (6MHP) have been associated with patient survival. We hypothesized
Kaposi sarcoma in <scp>HIV</scp> ‐negative men who have sex with men
Authors: E. Rashidghamat, C.B. Bunker, M. Bower, P. Banerjee
Journal: British Journal of Dermatology (2014)

Journal Article Kaposi sarcoma in HIV‐negative men who have sex with men Get access E. Rashidghamat, E. Rashidghamat Department of Dermatology University Hospital Lewisham London SE13 6LH U.K Search for other works by this author on: Oxford Academic Google Scholar C.B. Bunker, C.B. Bunker Department of Dermatology University College London Hospitals London U.K Search for other works by this author on: Oxford Academic Google Scholar M. Bower, M. Bower Department of Oncology Chelsea and Westminster Hospital London U.K Search for other works by this author on: Oxford Academic Google Scholar P. Banerjee P. Banerjee Department of Dermatology University Hospital Lewisham London SE13 6LH U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 171, Issue 5, 1 November 2014, Pages 1267–1268, https://doi.org/10.1111/bjd.13102 Published: 01 November 2014
The Great Breathlessness Mountains
Authors: Drummond Rennie
Journal: JAMA (1986)

Between 37 and 32 BC, the high Chinese official Too-Kin reported on the difficulties an armed escort would encounter crossing what was probably the Kilik Pass (4827 m, or 15 837 ft)<sup>1</sup>into what is now Afghanistan. He wrote of the lifeless desert, the absence of food, the proud yet cringing, cruel, and crafty inhabitants, and the route, which crosses "the Great Headache Mountain" and "the Little Headache Mountain" where "men's bodies become feverish, they lose colour, and are attacked with headache and vomiting."<sup>2</sup> What Too-Kin described was acute mountain sickness (AMS), which is a common affliction that comes on one or two days after ascending too high too fast. Acute mountain sickness is usually transient and is invariably cured by descent, but it may occasionally worsen and manifest itself as high-altitude cerebral and pulmonary edema (HACE and HAPE), both of which may be fatal, as was the
Visual Acuity Testing In Preschool Children
Authors: Leon J. Taubenhaus
Journal: JAMA (1969)

<h3>To the Editor:—</h3> The response to the question on the "E test" for visual acuity in preschool children, which appeared inThe Journal(<b>208</b>: 1195, 1969) does not discuss some of the other possibilities which, in my opinion, should be mentioned. In a study of 5,000 children, 3 through 6 years old, Jackson and I (<i>Vision Screening of 3- Through 5-Year-Old Children</i>, Brookline, Mass; Health Department, 1967) found that for the 3- through 4-year-old child, the Allen picture cards were superior to the Snellen E, Sjogren hand, or the Titmus screener. We completely agree that the commonest cause of inaccurate results is due to inadequate communications between the tester and the child. We also found that when a small child failed to respond to one type of test, he often responded correctly to another. We therefore think that every child who fails or does not respond to a specific preschool
PREDICT: A Simple Risk Score for Clinical Severity and Long-Term Prognosis After Hospitalization for Acute Myocardial Infarction or Unstable Angina
Authors: David R. Jacobs, Candyce Kroenke, Richard Crow, Mahesh Deshpande, Dong Feng Gu, Lael Gatewood, Henry Blackburn
Journal: Circulation (1999)

We evaluated short- and long-term mortality risks in 30- to 74-year-old patients hospitalized for acute myocardial infarction or unstable angina and developed a new score called PREDICT.PREDICT was based on information routinely collected in hospital. Predictors abstracted from hospital record items pertaining to the admission day, including shock, heart failure, ECG findings, cardiovascular disease history, kidney function, and age. Comorbidity was assessed from discharge diagnoses, and mortality was determined from death certificates. For 1985 and 1990 hospitalizations, the 6-year death rate in 6134 patients with 0 to 1 score points was 4%, increasing stepwise to 89% for >/=16 points. Score validity was established by only slightly attenuated mortality prediction in 3570 admissions in 1970 and 1980. When case severity was controlled for, 6-year risk declined 32% between 1970 and 1990. When PREDICT was held constant, 24% of those treated with thrombolysis died in 6 years compared with 31% of those not treated.The simple PREDICT risk score was a powerful prognosticator of 6-year mortality after hospitalization.
Flameless atomic absorption (FAA) and gas-liquid chromatographic studies in arsenic bioanalysis.
Authors: P Mushak, K Dessauer, E L Walls
Journal: Environmental Health Perspectives (1977)

Procedures for assessment of arsenic in soft tissue by use of flameless atomic absorption (FAA) and gas-liquid chromatography (GLC), have been evolved, with special emphasis on the analytical distinction among inorganic, monomethyl-, and dimethylarsenic in several oxidation states. The chemical bases for such speciation reside in several properties of the arsenicals under consideration: (1) pentavalent inorganic arsenic, methylarsonic, and cacodylic acid are not extracted from tissue matter made strongly acid with hydrochloric acid, while the corresponding trivalent forms (as halides) are extracted; (2) chloroform extracts of samples treated under reducing conditions (HCl-KI) retain organoarsenicals when these extracts are re-extracted with water, but do not when aqueous solutions of oxidants are employed; (3) reduced cacodylate (dimethylarsinous acid) is not detected in the graphite furnace of an FAA unit under conditions selected, while cacodylate can be so detected. For GLC studies, monomethyl- and dimethylarsenic are simultaneously measured as the diethyldithiocarbamate complexes with an instrument equipped for electron-capture detection and containing a glass column packed with silanized 5% OV-17 on Anakrom A.S.
TWENTY-FIVE YEARS' EXPERIENCE IN TREATMENT AND MANAGEMENT OF PERNICIOUS ANEMIA
Authors: William P. Murphy
Journal: JAMA (1952)

The story of pernicious anemia as it has evolved during the past century is both interesting and dramatic. As the various signs and symptoms have been added chapter by chapter, it has been possible to recognize the part that each would play as the story develops. During the past 25 years another chapter has been added that is now almost completed. The demonstration of the effectiveness of whole mammalian liver for the control of pernicious anemia was followed by the development of crude, then highly refined, extracts of liver for simplification of treatment, and, finally, by the recognition and isolation of the, or one of the, essential elements of liver. The final chapter has not been written, but it is, I hope, well started, for it is now possible to prevent pernicious anemia if its development is anticipated and the proper preventive therapy is instituted. Limitation of space makes it
Stress-induced Changes of Carbohydrate and Lipid Metabolism in Coronary Heart Disease (CHD)
Authors: J. Válek, E. Kuhn
Journal: Psychotherapy and Psychosomatics (1970)

In order to assess the role of stress in the metabolism of CHD patients we followed up in a group of 30 CHD patients–mean age 45 years -and an age-matched group of 21 controls the changes of blood lipids, blood glucose (BG), heart rate (HR) and blood pressure (BP) during a stressful laboratory situation. Higher increments of FFA, cholesterol, BG, BP and HR were recorded in the CHD group. No differences in the strength of emotion and personality traits -considering Leary's and Eysenck's inventories–were found. Higher levels of cholesterol or its increments were ascertained in CHD patients with dominant or aggressive traits. From the relationship of FFA, vanilmandelic acid and beta-lipo-proteins in CHD patients we presume a higher sensitivity of their lipid metabolism to stressful stimuli of daily life.
EFFECT OF PERCUTANEOUS BALLON MITRAL VALVULOPLASTY ON LEFT VENTRICULAR FUNCTION AS ESTIMATED BY TISSUE DOPPLER IMAGING AND ITS RELATION TO CHANGES IN N-TERMINAL PRO-BNP PLASMA LEVELS
Authors: Ahmed S. Ammar, Islam A. Elsherbiny, Kamal S. Mansour
Journal: Journal of the American College of Cardiology (2011)
Automobile Traffic, Atmospheric Pollution, and Childhood Asthma—Reply
Authors: Michael S. Friedman
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Conservative or nonconservative control schemes
Authors: Daniel M. Corcos, Kerstin Pfann
Journal: Behavioral and Brain Sciences (1995)

Abstract The conservative strategy proposed by the authors suggests a solution of the degrees-of-freedom problem of the controller. However, several simple motor control tasks cannot be explained by this strategy. A nonconservative strategy, in which more parameters of the control signal vary, can account for these simple motor tasks. However, the simplicity that distinguishes the proposed model from many others is lost.
An Adverse Effect of BAL in a Case of Subacute Arsenical Polyneuritis, with Observations on Porphyrin Metabolism
Authors: James H. Sands, Barnet Berris, L. Raymond Scherer
Journal: New England Journal of Medicine (1950)

BRITISH anti-lewisite (BAL) was first developed by Peters and his co-workers1 for the treatment of arsenical war-gas poisoning. It soon became apparent, however, that this compound could be used in the treatment of arsenical poisoning in general.Clinically, BAL has been used most extensively in the therapy of arsenical dermatitis, but it has also been employed in the treatment of blood dyscrasias due to arsenic, post-arsenical jaundice, arsenical encephalopathy and various other manifestations of arsenical poisoning. With the exception of post-arsenical jaundice, good results have been reported with this drug.It is the purpose of this paper to present a . . .
Medical Consultation on Surgical Services: An Annotated Bibliography
Authors: G M Caputo, R J Gross
Journal: Annals of Internal Medicine (1993)

Literature of Medicine15 February 1993Medical Consultation on Surgical Services: An Annotated BibliographyGregory M. Caputo, MD and Richard J. Gross, MDGregory M. Caputo, MDFrom the Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania, and the Francis Scott Key Medical Center and Johns Hopkins Hospital, Baltimore, Maryland.Search for more papers by this author and Richard J. Gross, MDFrom the Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania, and the Francis Scott Key Medical Center and Johns Hopkins Hospital, Baltimore, Maryland.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-4-199302150-00008 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail AbstractThis bibliography provides a literature base for residents on medical consultation services and for internists performing consultations in a field that is difficult to research through Index Medicus. Author, Article, and Disclosure InformationAffiliations: From the Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania, and the Francis Scott Key Medical Center and Johns Hopkins Hospital, Baltimore, Maryland.Corresponding Author: Gregory M. Caputo, MD, Division of General Internal Medicine, Milton S. Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, or Richard Gross, MD, Suite 101, 150 Scott Adam Road, Cockeyville, MD 21030.Acknowledgments: The authors thank Ms. Donna Harris for preparation of the manuscript and Dr. William S. Kammerer for support of this project. Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEssential Differences Between Evidence-Based Nursing and Evidence-Based MedicinePreoperative Assessment and Perioperative CarePreoperative Assessment and Perioperative Care 15 February 1993Volume 118, Issue 4Page: 290-297KeywordsAcute renal failureCardiac surgeryElderlyMedical risk factorsMortalityProphylaxisPulmonary embolismRandomized trialsSurgeryThorax ePublished: 15 August 2000 Issue Published: 15 February 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Reply to Joan Palou, Óscar Rodríguez and Noel Clarke’s Letter to the Editor re: Umberto Capitanio, Shahrokh F. Shariat, Hendrik Isbarn, et al. Comparison of Oncologic Outcomes for Open and Laparoscopic Nephroureterectomy: A Multi-Institutional Analysis of 1249 Cases. Eur Urol 2009;56:1–9
Authors: Giovanni Lughezzani, Shahrokh F. Shariat, Maxine Sun, Pierre I. Karakiewicz
Journal: European Urology (2009)
Rescuers of Migrants Require Health Protection
Authors: Phil Gunby
Journal: JAMA (1994)

HAITIANS CLINGING to overcrowded boats and Chinese confined to filthy ship holds in recent months have dramatized the dangers for undocumented individuals seeking US sanctuary. But what about those aboard US ships who are called on to intercept—and often to rescue—would-be immigrants at sea? The US Coast Guard is playing a major role in these efforts and its medical officers, like those of the other services, are aware that these US women and men in uniform can be exposed to tuberculosis, hepatitis, skin and intestinal parasites, dysentery, AIDS, and other diseases in the process. While the risk is not considered to be great, Alan M. Steinman, MD, who is a rear admiral, and the other 55 physicians of the US Coast Guard, as well as their physician counterparts in the US Navy, Army, and Air Force, are emphasizing preventive measures that can make the danger negligible. <h3>Military Medicine in Caribbean</h3>
TCT-382 Percutaneous and Surgical Circulatory Support for Medically Refractory Right Ventricular Failure with a Centrifugal-Flow Pump
Authors: Navin Kapur, Vikram Paruchuri, Michael Kiernan, Duc Pham, Anjan Chakrabarti, Duane Pinto, Daniel Steinberg, Nicole Orr, John Finley, Michael Templehoff, Nima Aghili, Samer Najjar, James Mudd, David DeNofrio
Journal: Journal of the American College of Cardiology (2012)
Identification of C-Met Oncogene as a Broadly Expressed Tumor-Associated Antigen Recognized by Cytotoxic T-Lymphocytes
Authors: Kerstin Schag, Susanne M. Schmidt, Martin R. Müller, Toni Weinschenk, Silke Appel, Markus M. Weck, Frank Grünebach, Stefan Stevanovic, Hans-Georg Rammensee, Peter Brossart
Journal: Clinical Cancer Research (2004)

Abstract Purpose: C-Met proto-oncogene is a receptor tyrosine kinase that mediates the oncogenic activities of the hepatocyte growth factor. Using a DNA chip analysis of tumor samples from patients with renal cell carcinoma and sequencing of peptides bound to the HLA-A*0201 molecules on tumor cells a peptide derived from the c-Met protein was identified recently. Experimental Design: We used this novel HLA-A*0201 peptide for the induction of specific CTLs to analyze the presentation of this epitope by malignant cells. Results: The induced CTL efficiently lysed target cells pulsed with the cognate peptide, as well as HLA-A*0201-matched tumor cell lines in an antigen-specific and HLA-restricted manner. Furthermore, the induced c-Met-specific CTLs recognized autologous dendritic cells (DCs) pulsed with the peptide or transfected with whole-tumor mRNA purified from c-Met-expressing cell lines. We next induced c-Met-specific CTLs using peripheral blood mononuclear cells and DC from an HLA-A*0201-positive patient with plasma cell leukemia to determine the recognition of primary autologous malignant cells. These CTLs lysed malignant plasma cells while sparing nonmalignant B- and T-lymphocytes, monocytes, and DCs. Conclusion: Our results demonstrate that c-Met oncogene is a novel tumor rejection antigen recognized by CTL and expressed on a broad variety of epithelial and hematopoietic malignant cells.