Treatment of Familial Mediterranean Fever with Anakinra
Authors: Rakiba Belkhir, Luc Moulonguet-Doleris, Eric Hachulla, Jacques Prinseau, Alain Baglin, Thomas Hanslik
Journal: Annals of Internal Medicine (2007)

Letters5 June 2007Treatment of Familial Mediterranean Fever with AnakinraRakiba Belkhir, MD, Luc Moulonguet-Doleris, MD, Eric Hachulla, MD, PhD, Jacques Prinseau, MD, Alain Baglin, MD, and Thomas Hanslik, MD, PhDRakiba Belkhir, MDFrom Hôpital Ambroise Paré, Boulogne 92104, France.Search for more papers by this author, Luc Moulonguet-Doleris, MDFrom Hôpital Ambroise Paré, Boulogne 92104, France.Search for more papers by this author, Eric Hachulla, MD, PhDFrom Hôpital Ambroise Paré, Boulogne 92104, France.Search for more papers by this author, Jacques Prinseau, MDFrom Hôpital Ambroise Paré, Boulogne 92104, France.Search for more papers by this author, Alain Baglin, MDFrom Hôpital Ambroise Paré, Boulogne 92104, France.Search for more papers by this author, and Thomas Hanslik, MD, PhDFrom Hôpital Ambroise Paré, Boulogne 92104, France.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-11-200706050-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: About 5% to 10% of patients with familial Mediterranean fever (FMF) have no clinical response to colchicine therapy, and no treatment recommendations exist for these cases (1). Interleukin-1 (IL-1) is a major proinflammatory cytokine that is increased in activity by pyrin, which is elevated in FMF (2, 3). Thus, blockade of IL-1 could in theory control the disease.Objective: To describe a woman with FMF who was refractory to colchicine treatment but who responded clinically to anakinra therapy, an IL-1–receptor antagonist.Case Report: A 68-year-old woman with FMF was treated with colchicine since her teens. The diagnosis was based ...References1. Onen F. Familial Mediterranean fever. Rheumatol Int. 2006;26:489-96. [PMID: 16283319] CrossrefMedlineGoogle Scholar2. Gumucio DL, Diaz A, Schaner P, Richards N, Babcock C, Schaller M, et al. Fire and ICE: the role of pyrin domain-containing proteins in inflammation and apoptosis. Clin Exp Rheumatol. 2002;20:S45-53. [PMID: 12371636] MedlineGoogle Scholar3. Chae JJ, Wood G, Masters SL, Richard K, Park G, Smith BJ, et al. The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. Proc Natl Acad Sci U S A. 2006;103:9982-7. [PMID: 16785446] CrossrefMedlineGoogle Scholar4. Peeters AC, Netea MG, Janssen MC, Kullberg BJ, Van der Meer JW, Thien T. Pro-inflammatory cytokines in patients with essential hypertension. Eur J Clin Invest. 2001;31:31-6. [PMID: 11168436] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Hôpital Ambroise Paré, Boulogne 92104, France.Disclosures: None disclosed. 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