tbuckley/cabot-search huggingface dataset:
Illness Among Gulf War Veterans
Authors: Joyce C. Lashof, Joseph S. Cassells
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation
Authors: Patrick S Tarpey, F Lucy Raymond, Lam S Nguyen, Jayson Rodriguez, Anna Hackett, Lucianne Vandeleur, Raffaella Smith, Cheryl Shoubridge, Sarah Edkins, Claire Stevens, Sarah O'Meara, Calli Tofts, Syd Barthorpe, Gemma Buck, Jennifer Cole, Kelly Halliday, Katy Hills, David Jones, Tatiana Mironenko, Janet Perry, Jennifer Varian, Sofie West, Sara Widaa, John Teague, Ed Dicks, Adam Butler, Andrew Menzies, David Richardson, Andrew Jenkinson, Rebecca Shepherd, Keiran Raine, Jenny Moon, Yin Luo, Josep Parnau, Shambhu S Bhat, Alison Gardner, Mark Corbett, Doug Brooks, Paul Thomas, Emma Parkinson-Lawrence, Mary E Porteous, John P Warner, Tracy Sanderson, Pauline Pearson, Richard J Simensen, Cindy Skinner, George Hoganson, Duane Superneau, Richard Wooster, Martin Bobrow, Gillian Turner, Roger E Stevenson, Charles E Schwartz, P Andrew Futreal, Anand K Srivastava, Michael R Stratton, Jozef Gécz
Journal: Nature Genetics (2007)
Cautions about Car Telephones and Collisions
Authors: Malcolm Maclure, Murray A. Mittleman
Journal: New England Journal of Medicine (1997)

Lawmakers in many countries are waiting for direct evidence that the use of cellular telephones in cars contributes to roadway collisions. In this issue of the Journal, a study of collisions in Toronto provides the first such evidence.1 By comparing the times of cellular-telephone calls, obtained from billing data, with the times of collisions, Redelmeier and Tibshirani estimated that the risk of a collision was between 3.0 and 6.5 times as high within 10 minutes after a cellular-telephone call began as when the telephone was not used. Our further analysis of their data confirmed that the risk more than doubled . . .
Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death
Authors: Alvaro Becerra, Cesar Echeverría, Diego Varela, Daniela Sarmiento, Ricardo Armisén, Felipe Nuñez-Villena, Mario Montecinos, Felipe Simon
Journal: Cardiovascular Research (2011)

Endothelial dysfunction is decisive in the progression of cardiovascular diseases. Lipopolysaccharide (LPS)-induced reactive oxygen species (ROS)-mediated endothelial cell death is a main feature observed in inflammation secondary to endotoxaemia, emerging as a leading cause of death among critically ill patients in intensive care units. However, the molecular mechanism underlying LPS-induced endothelial cell death is not well understood. Transient receptor protein melastatin 4 (TRPM4) is an ion channel associated with cell death that is expressed in endothelium and modulated by ROS. Here, we investigate the role of TRPM4 in LPS-induced endothelial cell death, testing whether suppression of the expression of TRPM4 confers endothelial cell resistance to LPS challenge.Using primary cultures of human umbilical vein endothelial cells (HUVEC), we demonstrate that TRPM4 is critically involved in LPS-induced endothelial cell death. HUVEC exposed to LPS results in Na(+)-dependent cell death. Pharmacological inhibition of TRPM4 with 9-phenanthrol or glibenclamide protects endothelium against LPS exposure for 48 h. Furthermore, TRPM4-like currents increase in cells pre-treated with LPS and inhibited with glibenclamide. Of note, suppression of TRPM4 expression by siRNA or suppression of its activity in a dominant negative mutant is effective in decreasing LPS-induced endothelial cell death when cells are exposed to LPS for 24-30 h.TRPM4 is critically involved in LPS-induced endothelial cell death. These results demonstrate that either pharmacological inhibition of TRPM4, suppression of TRPM4 expression, or inhibition of TRPM4 activity are able to protect endothelium against LPS injury. These results are useful in sepsis drug design and development of new strategies for sepsis therapy.
Diffuse Alveolar Hemorrhage with Underlying Pulmonary Capillaritis in the Retinoic Acid Syndrome
Authors: MARK R. NICOLLS, LANCE S. TERADA, RUBIN M. TUDER, SHEILA A. PRINDIVILLE, MARVIN I. SCHWARZ
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

All-trans-retinoic acid (ATRA) can induce a clinical remission in patients with acute promyelocytic leukemia. An adverse condition called "retinoic acid syndrome" limits this therapy. It is characterized by fever and respiratory distress, along with weight gain, pleural or pericardial effusions, peripheral edema, thromboembolic events, and intermittent hypotension. The lung disease has been previously ascribed to an infiltration of leukemic or maturing myeloid cells into lung parenchyma, which is sometimes associated with pleural effusions and diffuse alveolar hemorrhage. We report a case of retinoic acid syndrome in an 18-yr-old woman who developed diffuse alveolar hemorrhage while being treated with ATRA for acute promyelocytic leukemia. An open lung biopsy revealed pulmonary capillaritis.
Initiative to Implement 6 Key Measures in Hospital Care Called Lifesaving
Authors: Mike Mitka
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BRAIN NATRIURETIC PEPTIDE PROVIDES INCREMENTAL PROGNOSTIC UTILITY IN PATIENTS WITH AORTIC STENOSIS
Authors: Andrew L. Goodman, Roosha Parikh, Tyler Barr, Shikhar Agarwal, Richard Grimm, Joseph Sabik, Bruce Lytle, Leonardo Rodriguez, Lars Svensson, Brian Griffin, Milind Desai
Journal: Journal of the American College of Cardiology (2014)
Long-Term Sequelae of Spontaneous Axillary–Subclavian Venous Thrombosis
Authors: Emmanuel Héron, Olivier Lozinguez, Joseph Emmerich, Claude Laurian, Jean-Noël Fiessinger
Journal: Annals of Internal Medicine (1999)

The frequency and severity of post-thrombotic sequelae after spontaneous axillary-subclavian venous thrombosis remain poorly known.To determine the late sequelae of conventionally treated spontaneous axillary-subclavian venous thrombosis.Cross-sectional study.University department of vascular medicine.54 patients seen during an 18-year period (mean follow-up, 5 years).Scores for the severity of post-thrombotic symptoms were graded on a numerical rating scale ranging from 0 to 10 and on a 6-point verbal rating scale. Ultrasonographic sequelae were classified as grade 0, normal flow; grade 1, moderate obstruction; or grade 2, severe obstruction or occlusion.Verbal scores were "nil/negligible" in 47% of patients and "severe/intolerable" in 13%; numerical scores were 0 to 3 in 78% of patients and 7 to 10 in 9%. Grade 2 ultrasonographic sequelae were found in 22% of cases. No relation was seen between ultrasonographic sequelae and symptom severity scores.The overall clinical outcome of spontaneous axillary-subclavian venous thrombosis is good, and there is no relation between the severity of late symptoms and ultrasonographic sequelae.
Reversibility of Cirrhosis in Patients Cured of Thalassemia by Bone Marrow Transplantation
Authors: Pietro Muretto, Emanuele Angelucci, Guido Lucarelli
Journal: Annals of Internal Medicine (2002)

Background: Cirrhosis is a well-known complication of thalassemia major. In this context, it is a consequence of iron overload and hepatitis C virus infection and generally seems to be irreversible. Objective: To determine whether cirrhosis in thalassemia major can be reversible. Design: Retrospective study. Setting: Bone Marrow Transplantation Unit and Pathology Service, Pesaro Hospital, Pesaro, Italy. Patients: 6 patients who developed liver cirrhosis before or after their thalassemia was cured by bone marrow transplantation (age at transplantation, 11 to 25 years). After diagnosis of cirrhosis, the patients received iron depletion and antiviral therapies. Measurements: Each liver biopsy specimen was coded. A liver pathologist and a member of the transplantation center with expertise in hepatopathology graded the specimens by using the Ishak staging and grading systems. Neither knew the patient's identity or the sequence of biopsy with regard to the time of treatment. Results: After the patients received iron depletion and antiviral therapies, liver biopsy specimens showed impressive reduction in liver iron stores. In 4 patients, iron removal was complete. Serum aminotransferase levels decreased in all patients and normalized in 5; histologic inflammatory activity decreased in all patients and disappeared in 2. Follow-up biopsies showed regression of incomplete or definite cirrhosis in all patients; 3 patients had presented with portal fibrosis without bridging, and the others had portal fibrosis and portal-to-portal bridging. Several biopsies and the presence of many portal spaces confirmed the diagnosis of cirrhosis; follow-up biopsies confirmed regression of cirrhosis. Conclusion: In some patients in whom bone marrow transplantation has cured thalassemia, cirrhosis may be reversible after iron removal treatment.
P647 HAEMATOLOGICAL MANIFESTATIONS OF HEV GENOTYPE 3
Authors: A. Forbes, K.L. Woolson, L. Vine, L. Beynon, L. McElhinney, J.G. Hunter, R.G. Madden, T. Glasgow, A. Kruger, R.P. Bendall, U. Warshow, H.R. Dalton
Journal: Journal of Hepatology (2014)
Immunosuppression: Now we have choices
Authors: Linda S. Sher, Leonard Makowka
Journal: Hepatology (1995)

Background. Tacrolimus (FK 506), a macrolide compound isolated from a bacterium, is a potent immuno-suppressant with activity in solid-organ transplants. Most immunosuppressive regimens for liver transplantation are based on cyclosporine. Methods. We conducted an open-label, randomized, multicenter trial to compare the efficacy and safety of tacrolimus-based and cyclosporine-based immunosuppressive regimens for patients receiving a first liver transplant. A total of 478 adults and 51 children (≤12 years of age) were randomly assigned at the time of transplantation to receive tacrolimus (n = 263) or cyclosporine (n = 266) and were followed for one year. The primary end points were patient and graft survival at one year. The secondary end points were the incidence of acute rejection, corticosteroid-resistant rejection, and refractory rejection (continued rejection after two courses of corticosteroids and an intervening course of muromonab-CD3). Results. According to Kaplan-Meier analysis, actuarial patient-survival rates at day 360 were 88 percent for both the tacrolimus and cyclosporine groups ( P = 0.85; 95 percent confidence interval for the difference, −5.4 to 6.6 percent), and graft-survival rates were 82 percent and 79 percent, respectively ( P = 0.55; 95 percent confidence interval for the difference, −4.8 to 9.7 percent). Acute rejection occurred in 154 patients in the tacrolimus group and 173 patients in the cyclosporine group ( P &lt;0.002), corticosteroid-resistant rejection occurred in 43 and 82 patients, respectively ( P &lt;0.001), and refractory rejection occurred in 6 and 32 patients, respectively ( P &lt;0.001). Tacrolimus was associated with a higher incidence of adverse events requiring withdrawal from the study, primarily nephrotoxicity and neurotoxicity; 37 patients in the tacrolimus group and 13 in the cyclosporine group discontinued the study because of adverse events ( P &lt;0.001). Conclusions. After one year, immunosuppressive regimens based on tacrolimus and cyclosporine were comparable in terms of patient and graft survival. Tacrolimus was associated with significantly fewer episodes of acute, corticosteroid-resistant, or refractory rejection, but substantially more adverse events requiring discontinuation of the drug. (N Engl J Med 1994;331:1110-1115.)
Pulmonary Vein Ostium Geometry
Authors: Fred H.M. Wittkampf, Evert-Jan Vonken, Richard Derksen, Peter Loh, Birgitta Velthuis, Eric F.D. Wever, Lucas V.A. Boersma, Benno J. Rensing, Maarten-Jan Cramer
Journal: Circulation (2003)

Background— During a catheter ablation procedure for selective electrical isolation of pulmonary vein (PV) ostia, the size of these ostia is usually estimated using fluoroscopic angiography. This measurement may be misleading, however, because only the projected supero/inferior ostium diameters can be measured. In this study, we analyzed 3-dimensional magnetic resonance angiographic (MRA) images to measure the minimal and maximal cross-sectional diameter of PV ostia in relation to the diameter that would have been projected on fluoroscopic angiograms during a catheter ablation procedure. Methods and Results— In 42 patients with idiopathic atrial fibrillation who were scheduled for selective electrical isolation of PV ostia, the minimal and maximal diameters of these ostia were measured from 3-dimensional MRA images. Thereafter, these images were oriented in a 45° right or left anterior oblique direction and the projected diameter of the PV ostia were measured again. The average ratio between maximal and minimal diameter was 1.5±0.4 for the left and 1.2±0.1 for the right pulmonary vein ostia. Because of the orientation and oval shape of especially the left pulmonary vein ostia, their minimal diameters were significantly smaller than the projected diameters. Conclusion— Pulmonary vein ostia, especially those at the left, are oval with the short axis oriented approximately in the antero/posterior direction. Consequently, PV ostia may sometimes be very narrow despite a rather normal appearance on angiographic images obtained during a catheter ablation procedure.
RETINOIC ACID IN THE TREATMENT OF PSORIASIS
Authors: ANGUS MACDONALD, LIONEL FRY
Journal: British Journal of Dermatology (1972)

Summary.— Thirty-three patients with psoriasis applied retinoic acid ointment and betamethasone 17-valerate ointment to lesions on I side of their body, and a placebo ointment and identical betamethasone 17-valerate ointment to symmetrical lesions on the opposite side. Objective assessment of the treated areas showed a significant superiority of the retinoic acid and steroid over the placebo and steroid combination. The mode of action of retinoic acid in psoriasis is discussed.
Dermoscopy in black people
Authors: V. De Giorgi, E. Trez, C. Salvini, R. Duquia, D. De Villa, S. Sestini, R. Gervini, T. Lotti
Journal: British Journal of Dermatology (2006)

Little is known about the use of dermoscopy in nonwhite-skinned populations and whether it can influence diagnostic performance.To evaluate for the first time the utility and efficacy of dermoscopy in a black population for the diagnosis of pigmented cutaneous lesions.In total, 100 consecutive clinically doubtful or equivocal pigmented skin lesions in black patients were submitted to dermoscopic examination. The lesions were observed using dermoscopy by two groups of dermatologists, one in Brazil (in vivo) and the other in Italy (on slide images). Besides diagnosis, each group recorded on the same type of form the dermoscopic features present.Of 100 clinically suspicious cases, 79 were Clark naevi, 15 seborrhoeic keratoses, four blue naevi, one dermatofibroma and one melanoma. The two groups of observers succeeded in identifying and classifying all the lesions to such a margin of diagnostic accuracy that only a few cases (three Clark naevi) were subjected to surgical excision to confirm diagnosis.Darker pigmentation of the skin does not impede the identification of single dermoscopic features. As in lighter-skinned populations, dermoscopy in black people can also lead to early and accurate diagnosis of melanoma, thereby significantly reducing the number of unnecessary excisions.