tbuckley/cabot-search huggingface dataset:
HIV, AIDS and Childbearing
Authors: Cynthia B. Cohen
Journal: JAMA (1997)

AIDS and Childbearing Some might believe that women infected with the human immunodeficiency virus (HIV) who know they will die and who stand a 25% to 30% chance of having children who are HIV-infected ought not have children. This book sharply challenges that assumption. It develops a case for respecting the reproductive decisions of informed HIV-positive women, drawing from contributions by physicians, lawyers, ethicists, and public health professionals, as well as interviews with HIV-infected women and those who provide them with care. Each chapter in this rich mine of 17 contributions is well worth reading, not only by those with a special interest in the subject, but by those concerned about the appropriate role of health care professionals and government in influencing patient choices. The seminal argument in the volume is provided by Anita Allen, who maintains that it can be morally justifiable for women who are HIV-infected to have
Functional, cognitive and socio‐environmental determinants of hospital admission in elderly outpatients with heart failure
Authors: D. Del Sindaco, G. Pulignano, A.P. Maggioni, C. Greco, A. Iannucci, M. Alabisio, R. Pasotti, T. Zaccaria, E. Zampieri, C. Opasich
Journal: European Journal of Heart Failure (2000)
Oral 9, Hypocomplementaemic urticarial vasculitis: a rare but important cause of urticaria and angio-oedema
Authors: C. Roberts, A. Rangaraj, R. Murphy
Journal: British Journal of Dermatology (2007)

A 12-year-old girl presented initially with arthritis, back and abdominal pain, weight loss and lethargy. Preliminary blood tests showed a positive antinuclear factor, and low C3 and C4. Serum creatinine was normal but repeat urinalysis demonstrated a persistent proteinuria. A diagnosis of systemic lupus erythematosus was made and immunosuppressive treatment was commenced with hydroxychloroquine and prednisolone orally and methotrexate by intramuscular injection. Initially her joint symptoms slightly improved but after 3 months she was still complaining of lethargy with abdominal pains. She also complained of facial swelling and was noted to have urticaria on her face and limbs. Because of the urticaria and angio-oedema, low complement levels and abdominal pain, a diagnosis of hypocomplementaemic urticarial vasculitis (HUVS) was considered and serum C1q and C1q antibody titres were determined showing the presence of C1q antibodies and a low C1q titre. A diagnosis of HUVS was made and the immunosuppressive treatment was increased with pulsed methylprednisolone, with improvement of her symptoms. HUVS is a rare condition. Diagnosis depends on the presentation of hypocomplementaemia, urticaria and at least two of the following: vasculitis from dermal biopsies, arthralgia and arthritis, glomerulonephritis, uveitis or episcleritis, recurrent abdominal pain and the presence of C1q precipitating factor in the plasma.1,2 This disorder can present in isolation or in association with other diseases.2 Treatment of HUVS is notoriously difficult and affected individuals are at particular risk of end-stage renal disease. References 1 Schwartz HR, McDuffie FC, Black LF et al. Hypocomplementemic urticarial vasculitis: association with chronic pulmonary disease. Mayo Clinic Proc 1982; 57:231–8. 2 Walport MJ, Davies KA, Botto M. C1q and systemic lupus erythematosus. Immunobiology 1998; 199:265–85.
Plans to abolish bodies regulating fertility treatment and human tissues are discussed
Authors: S. Mayor
Journal: BMJ (2012)

Responsibility for regulating fertility treatment and use of human tissue in the UK should be transferred to the Care Quality Commission and research in these areas to the Health Research Authority, the Department of Health has recommended in a consultation published on 28 June.

The consultation is part of government plans, announced in July 2010, to halve the number of NHS quangos (quasi-autonomous national governmental organisations) to save an estimated £180m (€215m; $280m) by 2014-15 to help reach its target of reducing the NHS’s administrative costs by 45%.1 The Human Fertilisation and Embryology Authority (HFEA) and the Human Tissue Authority (HTA) were kept temporarily but were set to be abolished by April 2013.

After hearing arguments from organisations to retain the two bodies that currently regulate fertility treatment and human tissue the department said its preferred option is to transfer regulation to …
Contemporary Aspects of Discrete Peak-Detection Algorithms. II. The Paradigm of the Luteinizing Hormone Pulse Signal in Women*
Authors: WILLIAM S. EVANS, MICHAEL J. SOLLENBERGER, ROBERT A. BOOTH, ALAN D. ROGOL, RANDALL J. URBAN, ELISABETH C. CARLSEN, MICHAEL L. JOHNSON, JOHANNES D. VELDHUIS
Journal: Endocrine Reviews (1992)

ALONG-STANDING axiom in endocrine physiology is that normal reproductive function requires a highly coordinated interplay of events both within and among the components of the gonadal axis. Central to this axis are the gonadotropes, pituitary cells that synthesize and release the gonadotropins, LH and FSH. Of pivotal importance is the recognition that these trophic hormones, which are responsible for stimulating both the production of gonadal hormones and gametogenesis, are themselves secreted in a pulsatile fashion. Such pulsatile gonadotropin release reflects the integration of signals of both neural and gonadal origin that impinge upon the gonadotropes (Fig. 1). Indeed, the frequency with which the gonadotropins are released is believed in general to reflect the frequency with which quanta of GnRH are discharged by the hypothalamus, transported through the hypothalamic-hypophyseal portal circulation, and interact with appropriate receptors on responsive gonadotropes (1–6). The synthesis and secretion of GnRH itself are, in turn, modulated by catecholaminergic, serotoninergic, and opioid peptidergic as well as other neuromodulator systems within the hypothalamus and also by ambient concentrations of the gonadal hormones. Moreover, both in vitro and in vivo studies using the rat as a model have suggested that GnRH may feedback on itself via an ultrashort-loop system to inhibit its own secretion (7–9). Gonadotropin pulse amplitude may reflect both the amount of GnRH stimulating the gonadotrope and also the prevailing state of responsivity of the gonadotrope. Gonadotrope response characteristics appear to be a function not only of the neural signal, but also of the gonadal hormone milieu (10–23).
Gastrointestinal investigation of iron deficiency anaemia.
Authors: I J Cook, P Pavli, J W Riley, K J Goulston, O F Dent
Journal: BMJ (1986)

L'exploration du colon est essentielle chez les malades âges atteints d'anemie avec carence en fer et lesions benignes du tube digestif superieur decelees par endoscopie. On peut deceler des cancers ou adenomes du colon, ou d'autres lesions (angiodysplasie, colite ulcerative, maladie de Crohn, etc)
Physico-chemical properties and stability of anthralin in interaction with albumin, in suction blister fluid and intact human epidermis
Authors: M.T. DE SA E MELO, R. SANTUS, L. DUBERTRET
Journal: British Journal of Dermatology (1981)

Journal Article Physico‐chemical properties and stability of anthralin in interaction with albumin, in suction blister fluid and intact human epidermis Get access M.T. DE SA E MELO, M.T. DE SA E MELO * Laboratoire de Biophysique, Groupe Inserm U.201, 61 Rue Buffon, 75005 Paris Search for other works by this author on: Oxford Academic Google Scholar R. SANTUS, R. SANTUS * Laboratoire de Biophysique, Groupe Inserm U.201, 61 Rue Buffon, 75005 Paris Search for other works by this author on: Oxford Academic Google Scholar L. DUBERTRET L. DUBERTRET Laboratoirc de Physico‐Chimie de l'Adaptation Biologique, 43 Rue Cuvier, 75005 Paris, and ‡ Service Dermatologte, Hôpital Henri Mondor, 94010 Cretcil, France. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 105, Issue s20, 1 August 1981, Pages 20–22, https://doi.org/10.1111/j.1365-2133.1981.tb00993.x Published: 01 August 1981
Anesthesia and multiple sclerosis
Authors: David J. Birnbach, Angela Bader, Gerard W. Ostheimer
Journal: JAMA (1988)

To The Editor.—  We would like to respond to the article by Nelson et al1entitled Risk of Multiple Sclerosis Exacerbation During Pregnancy and Breast-feeding in the June 17, 1988, issue ofJAMA.  An area of major concern to obstetric anesthesiologists is the potential for exacerbation of the symptoms of multiple sclerosis after delivery. Although a correlation between the use of regional anesthesia (epidural and spinal) for labor and delivery has been suggested, no study thus far has demonstrated conclusively the role that regional anesthesia may play in an exacerbation of the disease.  In reviewing the records of all parturients with multiple sclerosis who received regional anesthesia for labor from 1982 through 1987, data at the Brigham and Women's Hospital, Boston, suggest that the choice of anesthetic may indeed affect the course of the disease.2This remains a controversial area in the practice of anesthesiology, and, unfortunately, there
Balancing budgets and protecting patient safety through the Toyota suggestion system
Authors: P. Pearson
Journal: BMJ (2014)

Ham paints a gloomy picture of the problems facing the English NHS.1 He seems to conclude that there are only two viable options: to increase staff numbers and not balance budgets or to cut costs and staff, “even if it means compromising patient safety and quality.” His third option of protecting patient safety and quality and balancing budgets receives no critique.

But this third option is the only viable long term …
Extrinsic allergic alveolitis in Scottish maltworkers.
Authors: I W Grant, E S Blackadder, M Greenberg, W Blyth
Journal: BMJ (1976)

In a survey of respiratory disease in the Scottish malting industry 5.2% of employees were found to have symptoms of extrinsic allergic alveolitis. In most cases the disease was mild and not associated with any serious respiratory disability. It was significantly less common where modern mechanical methods of malting were used. Mycological and serological studies suggested that it was usually caused by a type 3 allergic reaction to Aspergillus clavatus.
Economic evaluation and clinical trials: size matters
Authors: A. Briggs
Journal: BMJ (2000)

General practice pp 1383, 1389 

Randomised trials of health care interventions are increasingly attempting to tackle issues of cost effectiveness as well as clinical effectiveness. A good example of this appears in the two papers describing the clinical1 and economic evaluation2 of psychological therapies in primary care in this issue of the BMJ (pp 1383,1389). The use of clinical trials as a vehicle for prospective cost effectiveness analysis presents challenges for successful evaluation, and the methods of conducting trial based economic evaluation are still in their infancy.

Several commentators have emphasised that health economists should be involved from the outset in the design of trials that seek to report on cost effectiveness,3 rather than being asked to add in the economic variables as an adjunct to the main trial (in a so called “piggyback” arrangement).4 The reason for this is because design considerations are different for clinical and economic analyses.

The tendency of resource use variables to follow a skewed distribution5 means …
Deletion of the TSC2 and PKD1 genes associated with severe infantile polycystic kidney disease — a contiguous gene syndrome
Authors: Phillip T. Brook-Carter, Belén Peral, Christopher J. Ward, Peter Thompson, Jim Hughes, Magitha M. Maheshwar, Mark Nellist, Vicki Gamble, Peter C. Harris, Julian R. Sampson
Journal: Nature Genetics (1994)
Methods for the analysis of intestinal function.
Authors: C T Walsh, R R Levine
Journal: Environmental Health Perspectives (1979)

The intestinal tract, an organ of considerable complexity, requires application of numerous techniques for analysis of its physiology and perturbations by toxicologic agents. This review describes the methodology of importance in analysis of the absorptive function of the intestine and the transit of intestinal contents. Methods for studying absorption are categorized according to the technique for administering the test substance such as inclusion in the diet or by gastric and intestinal placement and the method of quantitating the degree of absorption such as determining the appearance of a test substance in systemic fluids or its disappearance from its site of administration in the intestine. In vitro techniques which have no in vivo analogs, such as the use of the everted sac, are briefly described and their limitations emphasized. Procedures of importance in the clinical diagnosis of malabsorption or in the experimental analysis of absorptive function in man are included and distinguished from techniques used in animal models. In addition, methods for studying aspects of gastrointestinal motility, including the use of luminal markers and analysis of the contractile and electrical activity of intestinal smooth muscle, are reviewed.
Titrating Oxygen During and After Cardiopulmonary Resuscitation
Authors: Patrick M. Kochanek
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopic submucosal dissection for residual/local recurrence of early gastric cancer after endoscopic mucosal resection
Authors: S. Oka, S. Tanaka, I. Kaneko, R. Mouri, M. Hirata, H. Kanao, T. Kawamura, S. Yoshida, M. Yoshihara, K. Chayama
Journal: Endoscopy (2006)

Endoscopic mucosal resection (EMR) is a widely accepted treatment for early gastric cancer; however, incomplete resection with residual local disease and recurrences continues to be a difficult problem. The aim of this study was to evaluate the efficacy and safety of endoscopic submucosal dissection (ESD) for residual/local recurrent early gastric cancer lesions after EMR.The en bloc resection rate, histologically complete resection rate, complications, and local recurrence were assessed in 15 patients who underwent ESD for residual/local recurrent early gastric cancer lesions after EMR.The nonlifting sign after injection of a glycerin solution was positive due to scar formation in all cases. En bloc resection was attempted in all cases, with a complete resection rate of 93.3 % (14 of 15). The lesion was completely resected with histologically adequate margins in the 14 patients who received complete en bloc resection. The average operation time was 85.4 +/- 52.9 min, and the mean follow-up period for all patients was 18.1 +/- 7.4 months. Major bleeding during the procedure in one case was the only complication (one of 15, 6.7 %). None of the patients experienced recurrence of early gastric cancer after ESD.ESD appears to be a safe and effective treatment for residual/local recurrent early gastric cancer lesions after EMR, and it is useful for histological confirmation of successful treatment.
Changes in sexual behaviour and the fall in incidence of HIV infection among homosexual men.
Authors: G. J. van Griensven, E. M. de Vroome, J. Goudsmit, R. A. Coutinho
Journal: BMJ (1989)

To investigate the epidemiology and normal course of infection with HIV the prevalence and incidence of the infection were studied among two cohorts of homosexual men in Amsterdam in 1980-7. The cumulative incidence of infection increased from a weighted 2.2% in 1980 to 39.0% in 1987. The estimated yearly incidence of HIV was 3.0% in 1981, rose to 8.8% in 1984, and fell gradually to 0% in 1987. During the study the sexual behaviour of the cohorts was examined. The number of men with whom anopenetrative intercourse was practised fell from a mean of 10.6 to 1.4 for those positive for HIV antibody, whereas the number with whom anoreceptive intercourse was practised fell from a mean of 3.7 to 0.5 for those negative for the antibody. In addition, there was a reduction in the number of cases of hepatitis B and syphilis among men in general. The decline in infection with HIV was assumed to be linked to changes in sexual behaviour. Such changes practised early in the course of the epidemic probably had a strong effect on the number of cases of AIDS among homosexual men in Amsterdam.
Unexpectedly high toxicity of MACOP‐B in young patients with low grade lymphoma
Authors: R. Arranz, G. Peréz, J. L. Steegmann, R. Cámara, J. F. Tomás, A. Figuera, L. Vazquez, J. M. Fernández‐Rañada
Journal: American Journal of Hematology (1991)

Abstract We report the results of treatment with MACOP‐B in 11 young patients with low grade lymphoma (LGL). Complete remission was obtained in 4 (57%) and partial remission in 3 (42.8%) of 7 evaluable patients. However, this aggressive chemotherapy has not offered any advantage because of an unacceptably high treatment‐related morbidity and mortality (17%). Serious infection during neutropenia was the most common complication.
Hepatitis C virus infection affects the brain—evidence from psychometric studies and magnetic resonance spectroscopy
Authors: Karin Weissenborn, Jochen Krause, Martin Bokemeyer, Hartmut Hecker, Andreas Schüler, Jochen C. Ennen, Björn Ahl, Michael P. Manns, Klaus W. Böker
Journal: Journal of Hepatology (2004)
Platelet factor 4 (PF-4)–induced neutrophil adhesion is controlled by src-kinases, whereas PF-4–mediated exocytosis requires the additional activation of p38 MAP kinase and phosphatidylinositol 3-kinase
Authors: Brigitte Kasper, Ernst Brandt, Silvia Bulfone-Paus, Frank Petersen
Journal: Blood (2003)
An Evaluation of Depleted Iron Stores in a Series of 1,332 Needle Biopsies of Marrow.
Authors: L. D. Ellis
Journal: Annals of Internal Medicine (1964)

s1 April 1964An Evaluation of Depleted Iron Stores in a Series of 1,332 Needle Biopsies of Marrow.L. D. Ellis, M.D., W. N. Jensen, M.D., M. P. Westerman, M.D.L. D. Ellis, M.D.Search for more papers by this author, W. N. Jensen, M.D.Search for more papers by this author, M. P. Westerman, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-727_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptConsecutive unselected bone marrow sections obtained by a modified needle biopsy procedure were examined for iron stores using the Prussian blue reaction. The sections obtained by this method are larger and have more intact marrow architecture than those obtained by marrow fragment or aspiration techniques.Absent marrow iron stores were present in 442 of the 1,332 biopsy specimens for an incidence of 33 per cent. The clinical records of 300 of these patients indicated that iron deficiency was not clinically recognized in 55 per cent. Fifty per cent of 38 patients with rheumatoid arthritis and 14 patients with systemic lupus... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIron Deficiency in Patients with Chronic Obstructive Airways Disease 1 April 1964Volume 60, Issue 4Page: 727-727KeywordsBiopsyBone marrowIron deficiencyRheumatoid arthritis Issue Published: 1 April 1964 PDF downloadLoading ...
Aplastic Anaemia Due to Phenylbutazone
Authors: G. R. Venning
Journal: BMJ (1957)

Aplastic Anaemia Due to PhenylbutazoneFatal agranulocytosis following phenylbutazone is now well recognized, but aplastic anaemia has been reported only by Leonard '(1953), whose patient had previously received gold therapy.The occurrence of fatal aplastic anaemia is here reported in a patient who had not previously been exposed to any bone-marrow poison. CASE HISTORYA married woman aged 55 complained of pains in the back and various joints over a period of 10 years, and was put on phenylbutazone therapy by her general practitioner in March, 1953.She was also on thyroid, 2 gr. (0.13 g.) daily, from January, 1953, onwards, a diagnosis of myx- oedema having been made at another hospital.Phenylbutazone was taken from March, 1953, until November, 1954, the dose at first being 200 mg.three times daily and
Stimulation of brain natriuretic peptide release from the heart by thyroid hormone
Authors: Masakazu Kohno, Takeshi Horio, Kenichi Yasunari, Koji Yokokawa, Miwako Ikeda, Naotsugu Kurihara, Yoshihiko Nishizawa, Hirotoshi Morii, Tadanao Takeda
Journal: Metabolism (1993)
The Retroisthmic Cleft Scintigraphic Appearance and Clinical Relevance in Patients With Low Back Pain
Authors: TITUS ABRAHAM, LAWRENCE HOLDER, CHARLES SILBERSTEIN
Journal: Clinical Nuclear Medicine (1997)

This article describes the scintigraphic appearance of both a symptomatic and asymptomatic retroisthmic cleft in two athletes with low back pain. This lesion, which involves the lamina, is the least common of the neural arch defects of which spondylolysis is the most common. The anatomy of the lesion is discussed and illustrated. The literature about the possible cause of these lesions is reviewed. The report emphasizes the valuable role of radionuclide bone imaging in patients who have pain of potentially osseous origin, and who have a lesion of uncertain physiologic significance seen on an anatomic study such as a plain x-ray, CT scan, or MRI.