tbuckley/cabot-search huggingface dataset:
Intravenous Dipyridamole Thallium-201 SPECT Imaging in Patients with Left Bundle Branch Block
Authors: JOHN F. ROCKETT, W CHADWICK WOOD, MOHAMMED MOINUDDIN, VIVIAN LOVELESS, BEVERLY PARRISH
Journal: Clinical Nuclear Medicine (1990)

TI-201 exercise imaging in patients with left bundle branch block (LBBB) has proven to be indeterminate for significant left anterior descending (LAD) coronary artery stenosis because of the presence of immediate septal perfusion defects with redistribution on delayed images in almost all cases. TI-201 redistribution occurs regardless of the presence or absence of LAD stenosis. Nineteen patients having LBBB were evaluated with dipyridamole TI-201 SPECT. Fourteen of these subjects had normal dipyridamole TI-201 SPECT imaging. Three patients had normal coronary angiograms. None of the remaining 11 patients with normal dipyridamole TI-201 SPECT images was found to have clinical coronary artery disease in a 5—11 month follow-up period. Five patients had abnormal septal perfusion. Four underwent coronary angiography. One had a significant LAD stenosis. The single patient with septal redistribution who refused to undergo coronary angiography died shortly thereafter of clinical coronary artery disease. This preliminary work suggests that dipyridamole TI-201 SPECT may be more useful for excluding LAD stenosis in patients with LBBB than TI-201 exercise imaging.
Low risk papillary thyroid cancer
Authors: J. P. Brito, I. D. Hay, J. C. Morris
Journal: BMJ (2014)

Thyroid cancer is one of the fastest growing diagnoses; more cases of thyroid cancer are found every year than all leukemias and cancers of the liver, pancreas, and stomach. Most of these incident cases are papillary in origin and are both small and localized. Patients with these small localized papillary thyroid cancers have a 99% survival rate at 20 years. In view of the excellent prognosis of these tumors, they have been denoted as low risk. The incidence of these low risk thyroid cancers is growing, probably because of the use of imaging technologies capable of exposing a large reservoir of subclinical disease. Despite their excellent prognosis, these subclinical low risk cancers are often treated aggressively. Although surgery is traditionally viewed as the cornerstone treatment for these tumors, there is less agreement about the extent of surgery (lobectomy <i>v</i> near total thyroidectomy) and whether prophylactic central neck dissection for removal of lymph nodes is needed. Many of these tumors are treated with radioactive iodine ablation and thyrotropin suppressive therapy, which—although effective for more aggressive forms of thyroid cancer—have not been shown to be of benefit in the management of these lesions. This review offers an evidence based approach to managing low risk papillary thyroid cancer. It also looks at the future of promising alternative surgical techniques, non-surgical minimally localized invasive therapies (ethanol ablation and laser ablation), and active surveillance, all of which form part of a more individualized treatment approach for low risk papillary thyroid tumors.
Importance of the timing of cyclosporine initiation in OKT3 treated cardiac transplant patients
Authors: Maria Rosa Costanzo-Nordin, Maryl R. Johnson, E.Jeanne O'Sullivan, G.Martin Mullen, Diane Wallis, Roque Pifarre, Patrick J. Scanlon, John A. Robinson
Journal: Journal of the American College of Cardiology (1990)
Aberrant DNA methylation ofp57KIP2 gene in the promoter region in lymphoid malignancies of B-cell phenotype
Authors: Yinghua Li, Hirokazu Nagai, Toshihito Ohno, Masaaki Yuge, Sonoko Hatano, Etsuro Ito, Naoyoshi Mori, Hidehiko Saito, Tomohiro Kinoshita
Journal: Blood (2002)
Late-onset skin fragility in childhood: a case of junctional epidermolysis bullosa of late onset caused by a missense mutation in<i>COL17A1</i>
Authors: S. Vanotti, C. Chiaverini, A. Charlesworth, N. Bonnet, P. Berbis, G. Meneguzzi, J.-P. Lacour
Journal: British Journal of Dermatology (2013)

Funding sources: none. Conflicts of interest: none. Dear Editor, Junctional epidermolysis bullosa (JEB) is a group of autosomal recessive inherited genodermatoses linked to mutations in genes encoding laminin (LM)332, integrin α6β4 or collagen type XVII.1 They are characterized by skin and mucosal fragility in the neonate and cleavage in the lamina lucida of the dermoepidermal junction (DEJ). JEB of late onset (JEB‐lo) is an exceedingly rare type of ‘JEB‐other’,2 3 4 characterized by delayed onset of skin fragility in childhood, which slowly and progressively worsens. Initially patients present acral blisters, which later extend to areas of continued friction such as the knees and elbows. Healing is normal with progressive skin atrophy and disappearance of dermatoglyphs. Palmoplantar hyperkeratosis is reported. Teeth and nails are often abnormal. Mucosal involvement is inconsistent and usually limited to mild oral blistering without scarring. Recently, Yuen et al.5 reported genetic mutations affecting the collagen type XVII gene (COL17A1) in two siblings with JEB‐lo. Here we present a patient with JEB‐lo resulting from abnormal expression of collagen type XVII caused by a homozygous missense mutation in COL17A1.
Screening &amp;amp; Obstructive Treatment Program Pulmonary Disease for Mild Chronic
Authors: Terry R. Baker
Journal: JAMA (1970)

Seven hundred and fifty men were screened for the presence of mild chronic obstructive pulmonary disease, and 134 subjects were enrolled in a therapy program. The findings of follow-up interviews, physical examinations, and laboratory tests were correlated with the screening results. Among those completing six months of therapy, there was a marked improvement of respiratory symptoms, but no significant change in pulmonary function. Cessation of cigarette smoking was most closely associated with the symptomatic improvement.
PSYCHIATRIC FINDINGS IN FATIGUE
Authors: ROBERT S. SCHWAB, THOMAS DELORME
Journal: American Journal of Psychiatry (1953)

We have studied fatigue curves in 65 normal subjects, 50 patients with myasthenia gravis, 25 patients with Parkinson's disease, 50 patients with miscellaneous neurological conditions such as poliomyelitis, arthritis, and dystrophy, and 40 patients who did not have any structural disease of their muscular or nervous systems but whose complaint was chronic fatigue and who had symptoms of nervousness, indicating that their fatigue was of psychogenic origin. The site of pathology of the fatigue in the neurological cases mentioned may be in the muscle, the end-plate, or in the peripheral nerve. However, the source of the fatigue complaint in patients with chronic fatigue of nonneurological nature and not due to medical diseases lies in the brain. Treatment of this type of disease must be directed toward determining the psychological causes of the fatigue and correcting them. The prescribing of muscular rest with the idea that the muscles are at fault is a waste of time.
Long-Term Weight Patterns and Risk for Cholecystectomy in Women
Authors: Sapna Syngal
Journal: Annals of Internal Medicine (1999)

Obesity and rapid weight loss in obese persons are known risk factors for gallstones. However, the effect of intentional, long-term, moderate weight changes on the risk for gallstones is unclear.To study long-term weight patterns in a cohort of women and to examine the relation between weight pattern and risk for cholecystectomy.Prospective cohort study.11 U.S. states.47,153 female registered nurses who did not undergo cholecystectomy before 1988.Cholecystectomy between 1988 and 1994 (ascertained by patient self-report).During the exposure period (1972 to 1988), there was evidence of substantial variation in weight due to intentional weight loss during adulthood. Among cohort patients, 54.9% reported weight cycling with at least one episode of intentional weight loss associated with regain. Of the total cohort, 20.1% were light cyclers (5 to 9 lb of weight loss and gain), 18.8% were moderate cyclers (10 to 19 lb of weight loss and gain), and 16.0% were severe cyclers (> or = 20 lb of weight loss and gain). Net weight gain without cycling occurred in 29.3% of women; net weight loss without cycling was the least common pattern (4.6%). Only 11.1% of the cohort maintained weight within 5 lb over the 16-year period. In the study, 1751 women had undergone cholecystectomy between 1988 and 1994. Compared with weight maintainers, the relative risk for cholecystectomy (adjusted for body mass index, age, alcohol intake, fat intake, and smoking) was 1.20 (95% CI, 0.96 to 1.50) among light cyclers, 1.31 among moderate cyclers (CI, 1.05 to 1.64), and 1.68 among severe cyclers (CI, 1.34 to 2.10).Weight cycling was highly prevalent in this large cohort of middle-aged women. The risk for cholecystectomy associated with weight cycling was substantial, independent of attained relative body weight.
Oxygen sensors in hypoxic pulmonary vasoconstriction
Authors: N WEISSMANN, N SOMMER, R SCHERMULY, H GHOFRANI, W SEEGER, F GRIMMINGER
Journal: Cardiovascular Research (2006)

Hypoxic pulmonary vasoconstriction (HPV) is an essential mechanism adapting lung perfusion to regional ventilation. Perturbations to HPV, such as those occurring in pneumonia, acute respiratory distress syndrome and liver failure, can result in arterial hypoxemia. Under conditions of general hypoxia, HPV increases pulmonary vascular resistance and thus causes acute pulmonary hypertension. Despite intensive research, the underlying mechanisms of HPV have not been fully elucidated. Deciphering signalling pathways that result in HPV could suggest novel approaches to address a failure of HPV, as well as for the treatment of pulmonary hypertension associated with HPV. Within this context, this review focuses on current concepts in the oxygen sensing mechanisms that underlie HPV.
Serotonin Syndrome Associated With Clozapine Withdrawal
Authors: Elizabeth Stevenson, Frank Schembri, Deborah M. Green, Joseph D. Burns
Journal: JAMA Neurology (2013)

We describe a case of serotonin syndrome secondary to clozapine withdrawal and concomitant use of citalopram hydrobromide, a phenomenon that has been rarely reported.This is a case report of a 47-year-old woman admitted to an academic medical center intensive care unit with coma, hypersalivation, hyperreflexia, and stimulus-induced clonus. The patient received a diagnosis of serotonin syndrome attributed to abrupt clozapine withdrawal with concomitant use of citalopram. She improved only minimally with supportive treatment (intravenous fluids, benzodiazapines, and withdrawal of selective serotonin-reuptake inhibitor) and received cyproheptadine hydrochloride on her third day of symptoms. Four hours after she received the loading dose of cyproheptadine, she was alert and oriented and at her baseline mental status, although some clonus remained.Serotonin syndrome can result from the abrupt withdrawal of a 5-hydroxytryptamine receptor 2A antagonist from a treatment regimen that also includes a medication that increases serotonin availability.
Radioiodine Treatment of Graves' Disease
Authors: GORDON D. GRAHAM
Journal: Annals of Internal Medicine (1986)

Concern about the side effects of radiation exposure has deterred physicians from using radioiodine treatment for Graves' disease, although the efficacy and safety of this treatment have been established in the 35 years since its introduction. In that time, no significant side effects have been discovered. We believe iodine-131 should be considered the treatment of choice in most patients with Graves' disease. This article reviews the current understanding of the risks in radioiodine treatment of Graves' disease, including the risks for teratogenicity, genetic damage, carcinogenesis, and cellular dysfunction.
AMA Auxiliary Activities
Authors: Glenda Bates
Journal: JAMA (1984)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Novel Clinical Course Of IgE-mediated, Late-onset Anaphylaxis After Ingestion Bacillus Subtilis-Fermented Soybeans (natto): Clinical Review Of 7 Patients
Authors: N. Inomata, H. Osuna, K. Kawano, J. Yamaguchi, M. Yanagimachi, Z. Ikezawa
Journal: Journal of Allergy and Clinical Immunology (2007)
Is a tattoo the answer?
Authors: C. Polack
Journal: BMJ (2001)

My 83 year old grandmother wants a tattoo. She feels it would help reduce one of her great fears. She worries that if she collapsed someone would try to resuscitate her; she therefore wants “Do not resuscitate” tattooed on her chest. She is not ill, she is not depressed, she simply feels that she has had a good life and is ready to leave it whenever nature decides to end her time. She wants no fuss, no money spent. She worries about losing her independence, about getting dementia; a sudden collapse would be her perfect death, so …
Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia
Authors: M Matsunawa, R Yamamoto, M Sanada, A Sato-Otsubo, Y Shiozawa, K Yoshida, M Otsu, Y Shiraishi, S Miyano, K Isono, H Koseki, H Nakauchi, S Ogawa
Journal: Leukemia (2014)
Methylene blue-aided cholangioscopy in patients with biliary strictures: feasibility and outcome analysis. Reply to Maetani
Authors: A. Hoffman, M. Neurath
Journal: Endoscopy (2008)

We read Professor Maetani’s letter and comments about our study [1] with great interest. Maetani also reported their previous experience with methylene blue in the bile duct [2]. In their study protocol, the bile duct was analyzed by percutaneous cholangioscopy. Differences in methylene blue staining properties between cancerous and noncancerous epithelia were noted. Furthermore, endoscopic findings were compared with data on frozen sections of epithelia. Their investigation revealed that microscopic staining properties were not always significantly associated with endoscopic observations. Whereas 18 of 20 (90 %) specimens of normal epithelia revealed positive staining with methylene blue, 11 out of 16 (69 %) specimens of metaplastic epithelia were stained, with no staining obtained in cancerous epithelia. The cancerous epithelia stained significantly less often than either the normal or the metaplastic epithelia.
ANTIVENIN THERAPEUSIS IN PURPURA
Authors: MAX R. STOCKTON
Journal: JAMA (1931)

The following case report is submitted with the idea of stimulating further study in the use of antivenin in purpura:  A. P., a healthy white soldier, aged 23, for the past two years featherweight champion of the Canal Zone, was admitted to Gorgas Hospital, Dec. 30, 1929, for a submucous resection and tonsillectomy. His family history, previous personal history and complete physical examination were negative. His Wassermann reaction was negative and the coagulation time and urine were normal. This man, during his career as a fighter, had been struck on the nose many times and the bleeding that followed always ceased quickly. His left foot showed a small deep recent operative scar and he stated that the incision had healed rapidly and with but little bleeding.  December 31, a submucous resection under local anesthesia was performed. With the exception of the mechanical difficulties involved, due to the previous multiple fractures,
Angioplasty of complex lesions in ischemic rest angina: Results of the Thrombolysis and Angioplasty in Unstable Angina (TAUSA) Trial
Authors: Roxana Mehran, John A. Ambrose, Ram Mohan Bongu, Orlandino D. Almeida, Douglas H. Israel, Sabino Torre, Samin K. Sharma, Denise E. Ratner
Journal: Journal of the American College of Cardiology (1995)
Sports academies: the way to win
Authors: Ilkka J Väänänen, Tero T Kuorikoski
Journal: British Journal of Sports Medicine (2010)

The aim of this abstract is to review the policies and practices of sports academies as a part of the elite sport system in Finland. The mission of Finnish Sports Academies is to assist young elite athletes to pursue their education, while also training and competing at an elite level. There are 15 sport academies in the Finnish Sport Academy Network regulated by the Finnish Olympic Committee. In Lahti region Päijät-Häme Sports Academy (PHSA) was started as a project in 2005 coordinated by Lahti University of Applied Sciences and now it is an independent network association. PHSA helps regional top athletes to integrate studies and sports, and even work if necessary, together. There are almost 100 student-athletes, several study counsellors and coaches in action. The backup given to the student-athletes by PHSA varies from professional coaching and testing, muscle balance analysis, mental training and sports psychology, sport physician, physiotherapy and massage, training equipments and facilities to study guidance and career counselling. Lectures are also held on subjects such as anti-doping, an athlete's nutrition, media skills, sport ethics and life management. The PHSA strategic sports are basketball, judo, ski jumping and figure skating. Other PHSA support sports are ice hockey, soccer, volleyball, track and field, cross country skiing, golf and wrestling. Our values are veracity and openness, athlete-driven, co-operation, responsibility and equity. Finnish Sport Academy system helps student-athletes to play and triumph successfully. It makes dreams come true.
Your Guide to Mental Help
Authors: Alan L. Krueger
Journal: JAMA (1983)

The implied purpose of this text is to provide a better understanding of emotional problems and a guide to obtaining "mental help." It is one of a series of books in the People's Health Library. It is intended to be an easy-to-read book and is written for the lay public. The 146-page text has two main divisions: "Types of Problems" and "Mental Help." There are 16 chapters in the section on "Types of Problems" that attempt to cover the broad scope of psychiatric disorders. An additional eight chapters are written as a guide to understanding and obtaining help for the identified problems. Each chapter has as its format a series of questions and answers. Indeed, much of the text seems as if it is a loose compilation of questions by readers of a syndicated newspaper column. Inconsistency is a major deficiency. Professional jargon is mixed with simplistic lay terminology. Many
Endogenous Nitric Oxide and the Pulmonary Microvasculature in Healthy Sheep and during Systemic Inflammation
Authors: F. HINDER, J. MEYER, M. BOOKE, J. S. EHARDT, J. R. SALSBURY, L. D. TRABER, D. L. TRABER
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Nitric oxide (NO) influences microvascular integrity. NO synthase inhibitors are regarded as therapeutic options, but their impact on the pulmonary microvasculature is not well defined. We studied the microvascular effects of the nonselective NO synthase inhibitor Nω-nitro l-arginine methylester (l-NAME) in healthy sheep and during systemic inflammation. Permeability analysis was performed in 30 adult ewes with chronic lung lymph fistulas and pulmonary venous occluders. Experiment 1: 20 sheep received Escherichia coli endotoxin (lipopolysaccharide, 10 ng/kg/min) for 32 h. After 24 h of endotoxemia, 10 sheep were given l-NAME (25 mg/kg), and 10 sheep received NaCl 0.9%. Experiment 2: six sheep were treated with l-NAME (25 mg/kg), and four animals received NaCl 0.9%. Endotoxin induced a phasic pulmonary microvascular response with early transiently increased endothelial permeability at 4 h and late normalization of microvascular integrity to large molecules after 24 h. At that time systemic vasodilation had occurred. l-NAME raised pulmonary artery pressure and pulmonary vascular resistance index without signs of increased permeability in either experiment. NO is involved in vascular tone in healthy sheep and during systemic inflammation, but it does not seem to play a role in the integrity of the pulmonary microvascular barrier function to large molecules.
THE TREATMENT OF ARTHRITIS DEFORMANS WITH THE ROENTGEN RAYS.A PRELIMINARY REPORT.
Authors: J. M. ANDERS
Journal: JAMA (1906)

We submit this preliminary report on the treatment of arthritis deformans with the Roentgen rays, and hope at a later date to make a more complete report on these and similar cases and then to be able to draw more definite conclusions. <h3>Case 1.</h3> —Mr. T. J., aged 47, a miner, was admitted to the wards of the Medico-Chirurgical Hospital under the care of Dr. Anders Oct. 26, 1905. The man's father died of miner's asthma, otherwise the family history is negative. His previous medical and social history have no bearing on the disease. <h3>Present Illness.</h3> —This dates from July, 1902, when his feet, especially the joints of the toes, became swollen, tender and painful. This kept him from work one year; he then improved and was able to work four months. Since that time, which was fifteen months before admission to the hospital, he has not worked on account
Imipramine in Depressive Illness
Authors: E. West
Journal: BMJ (1964)

The findings in this paper contradict a good deal of clinical experience in the beneficial effects of antidepressant drugs on certain depressed patients.These drugs may not provide much relief for the severely depressed patient, but in a considerable number of less severely depressed patients the effect on the mood state seems specific and not simply the result of a sedative action, as suggested by the authors.More striking results might be obtained if a similar trial were to be per- formed in patients suffering from depression seen at a stage before they had been selected by failure to respond to antidepressants.How to find such patients, however, is difficult to suggest.-Iam, etc.,
Protein A is the von Willebrand factor binding protein onStaphylococcus aureus
Authors: Jörg Hartleib, Nicola Köhler, Richard B. Dickinson, Gursharan S. Chhatwal, Jan J. Sixma, Orla M. Hartford, Timothy J. Foster, Georg Peters, Beate E. Kehrel, Mathias Herrmann
Journal: Blood (2000)
Population-Based Studies of Adverse Drug Effects
Authors: Wayne A Ray
Journal: New England Journal of Medicine (2003)

The prescription of medications has long been the most frequent therapeutic intervention in medicine. In 2000 in the United States, 173 million people filled 2.2 billion outpatient prescriptions, accounting for $103 billion in expenditures. Because all medications have risks, the appropriate therapeutic use of pharmaceutical agents requires quantitative information on safety as well as efficacy.In this issue of the Journal, a thoughtful investigation reported by Strom and colleagues (pages 1628–1635) shows that patients who have had a hypersensitivity reaction to sulfonamide antibiotics are no more likely to have a reaction to nonantibiotic sulfonamides than are patients who have had . . .
Corrigendum to “Homing of bone marrow mesenchymal stem cells mediated by sphingosine 1-phosphate contributes to liver fibrosis” [J Hepatol 50 (2009) 1174–1183]
Authors: Changyong Li, Yaxian Kong, Hong Wang, Shuling Wang, Hao Yu, Xin Liu, Lin Yang, Xiangming Jiang, Lingsong Li, Liying Li
Journal: Journal of Hepatology (2009)