Recurrence Rates of Genital Herpes
Authors: Lawrence Corey
Journal: Annals of Internal Medicine (1995)

Letters1 June 1995Recurrence Rates of Genital HerpesLawrence Corey, Jacqueline Benedetti, and Rhoda AshleyLawrence CoreyRoyal Perth Hospital, Perth, Western Australia 6001, Australia. University of Washington School of Medicine, Seattle, WA 98144.Search for more papers by this author, Jacqueline BenedettiRoyal Perth Hospital, Perth, Western Australia 6001, Australia. University of Washington School of Medicine, Seattle, WA 98144.Search for more papers by this author, and Rhoda AshleyRoyal Perth Hospital, Perth, Western Australia 6001, Australia. University of Washington School of Medicine, Seattle, WA 98144.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-11-199506010-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Drs. Marshall and Purnell are correct that our study group had a low seroprevalence of HSV-1 infection. Most serosurveys suggest that approximately half of the persons with HSV-2 antibody also have HSV-1 antibodies [1]. In our cohort of patients with a first episode of genital herpes, only 13% were seropositive for HSV-1 infection. As we have shown [2], previous HSV-1 infection lessens the severity of HSV-2 infection and increases the frequency of unrecognized genital HSV infection. As such, we would expect this distribution of HSV antibodies in a study designed to evaluate the natural history of first-episode infections ...References1. Johnson RE, Nahmias AJ, Magder LS, Lee FK, Brooks CA, Snowden CB. A seroepidemiologic survey of the prevalence of herpes simplex virus type 2 infection in the United States. N Engl J Med. 1989; 321:7-12. Google Scholar2. Koutsky LA, Ashley RL, Holmes KK, Stevens CE, Critchlow CW, Kiviat N, et al. The frequency of unrecognized type 2 herpes simplex virus infection among women. Implications for the control of genital herpes. Sex Trans Dis. 1990; 17:90-4. Google Scholar3. Benedetti J, Corey L, Ashley R. Recurrence rates in genital herpes after symptomatic first-episode infection. Ann Intern Med. 1994; 121:847-54. Google Scholar4. Wald A, Zeh J, Selke S, Ashley RL, Corey L. Virologic characteristics of subclinical and symptomatic genital herpes infections. N Engl J Med. 1995; (In press). Google Scholar5. Langenberg A, Benedetti J, Jenkins J, Ashley R, Winter C, Corey L. Development of clinically recognizable genital lesions among women previously identified as having “asymptomatic” herpes simplex virus type 2 infection. Ann Intern Med. 1980; 110:882-7. Google Scholar Author, Article, and Disclosure InformationAuthors: Lawrence Corey; Jacqueline Benedetti; Rhoda AshleyAffiliations: Royal Perth Hospital, Perth, Western Australia 6001, Australia. University of Washington School of Medicine, Seattle, WA 98144. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1995Volume 122, Issue 11Page: 883KeywordsGenital anatomyHealth careHerpes simplexInfectious diseasesLesionsMorbidity ePublished: 15 August 2000 Issue Published: 1 June 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...