Carrier Transport and the Concentration of Glucose in Cerebrospinal Fluid in Meningeal Diseases
Authors: ROBERT A. FISHMAN
Journal: Annals of Internal Medicine (1965)

Editorials1 July 1965Carrier Transport and the Concentration of Glucose in Cerebrospinal Fluid in Meningeal DiseasesROBERT A. FISHMAN, M.D.ROBERT A. FISHMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-1-153 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe diagnostic value of lumbar puncture was established in the early years of this century with particular reference to the changes in the cellular and chemical constituents of the fluid. A reduced concentration of glucose was recognized as characteristic of purulent meningitis and, subsequently, hypoglycorrhachia was also noted to occur with a variety of meningeal disorders, including tuberculous, fungal, and luetic meningitis, subarachnoid hemorrhage, meningeal sarcoidosis, and carcinomatosis. In this issue of the ANNALS OFINTERNALMEDICINE, Kim and Resnick report two additional cases in which the diagnosis of carcinomatous meningitis could be made when marked depression of the cerebrospinal...References1. FISHMAN RA: Carrier transport of glucose between blood and cerebrospinal fluid. Amer. J. Physiol. 206: 836, 1964. CrossrefMedlineGoogle Scholar2. WILBRANDTROSENBERG WT: The concept of carrier transport and its corollaries in pharmacology. Pharmacol Rev. 13: 109, 1961. MedlineGoogle Scholar3. FISHMAN RA: Unpublished observations. Google Scholar4. CSÁKY TZ: A possible link between active transport of electrolytes and nonelectrolytes. Fed. Proc. 22: 3, 1963. MedlineGoogle Scholar5. WILLIAMSMCCORD RDA: Diffusion of glucose through blood-cerebrospinal fluid barrier in normal dogs. Amer. J. Physiol. 203: 453, 1962. CrossrefMedlineGoogle Scholar6. PROCKOPSCHANKERBRODIE LDLSBB: Passage of lipid-insoluble substances from cerebrospinal fluid to blood. J. Pharmacol. Exp. Ther. 135: 266, 1962. MedlineGoogle Scholar7. PETERSDORFHARTER RD: The fall in cerebrospinal fluid sugar in meningitis. Arch. Neurol. (Chicago) 4: 21, 1961. CrossrefMedlineGoogle Scholar8. SIFONTESWILLIAMSLINCOLNCLEMONS JERDEMH: Observations on the effect of induced hyperglycemia on the glucose content of the cerebrospinal fluid in patients with tuberculous meningitis. Amer. Rev. Tuberc. 67: 732, 1953. Google Scholar9. FISHMAN RA: Studies of the transport of sugars between blood and cerebrospinal fluid in normal states and in meningeal carcinomatosis. Trans. Amer. Neurol. Ass. 88: 114, 1963. MedlineGoogle Scholar10. MERRITTFREMONT-SMITH HHF: The Cerebrospinal Fluid. W. B. Saunders Co., Philadelphia, 1937. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT A. FISHMAN, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIs a low cerebrospinal fluid blood glucose ratio indicative of infection in patients with post haemorrhagic hydrocephalus?The Glucose-Transporter Protein and Glucopenic Brain InjurySarcoidosis Presenting as Progressive Ascending Lower Extremity Weakness and Asymptomatic Meningitis with HypoglycorrhachiaRheumatoid Meningitis: A Localized Immune ProcessJOSEPH A. MARKENSON, M.D., J. STEVEN McDOUGAL, M.D., PETER TSAIRIS, M.D., MICHAEL D. LOCKSHIN, M.D., CHARLES L. CHRISTIAN, M.D.Neurologic Manifestations in Sarcoidosis Review of the Literature, with a Report of 23 CasesPEYTON DELANEY, M.D.General Metabolic Characteristics in CancerVariações da taxa de açúcar no líquido cefalorraqueano em casos de derrame de sangue no espaço sub-aracnóide com especial referência à hipoglicorraquiaMumps Meningoencephalitis with Low Cerebrospinal-Fluid Glucose, Prolonged Pleocytosis and Elevation of ProteinIodide transfer at four cerebrospinal fluid sites in the dog: Evidence for spinal iodide carrier transportDexamethasone in Tuberculous Meningitis Relationship of Cerebrospinal Fluid Effects to Therapeutic EfficacyRICHARD D. O'TOOLE, M.D., GEORGE F. THORNTON, M.D., MRINAL K. MUKHERJEE, D.P.H., R. L. NATH, PH.D.Pleural Effusion in Rheumatoid Arthritis 1 July 1965Volume 63, Issue 1 Page: 153-155 Keywords Attention Carcinomatosis Cerebrospinal fluid Glucose Lumbar puncture Meningitis Sarcoidosis Subarachnoid hemorrhage ePublished: 1 December 2008 Issue Published: 1 July 1965 PDF downloadLoading ...