tbuckley/cabot-search huggingface dataset:
Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice
Authors: X PENG, H UEDA, H ZHOU, T STOKOL, T SHEN, A ALCARAZ, T NAGY, J VASSALLI, J GUAN
Journal: Cardiovascular Research (2004)

Journal Article Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice Get access Xu Peng, Xu Peng aDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Hiroki Ueda, Hiroki Ueda aDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Hongming Zhou, Hongming Zhou bDepartment of Morphology, Medical Faculty of University of Geneva, Geneva, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar Tracy Stokol, Tracy Stokol aDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USAcDepartment of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Tang-Long Shen, Tang-Long Shen aDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Ana Alcaraz, Ana Alcaraz dDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Tamas Nagy, Tamas Nagy aDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Jean-Dominique Vassalli, Jean-Dominique Vassalli bDepartment of Morphology, Medical Faculty of University of Geneva, Geneva, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar Jun-Lin Guan Jun-Lin Guan * aDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA *Corresponding author. Tel.: +1 (607) 253 3586; fax: (607) 253 3708. Email address: [email protected] Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 64, Issue 3, December 2004, Pages 421–430, https://doi.org/10.1016/j.cardiores.2004.07.012 Published: 01 December 2004 Article history Received: 01 March 2004 Revision received: 29 June 2004 Accepted: 16 July 2004 Published: 01 December 2004
STUDIES ON INFLUENZA INFECTION IN FERRETS BY MEANS OF FLUORESCEIN-LABELLED ANTIBODY
Authors: Ch'ien Liu
Journal: The Journal of Experimental Medicine (1955)

By means of fluorescein-labelled antibody staining, specific influenza viral antigens were seen in both the cytoplasm and the nucleus of infected ciliated epithelial cells covering the nasal turbinates of infected ferrets. Initially, only a small portion of the nasal epithelium showed fluorescence, and no appreciable abnormality of the cells could be detected by hematoxylin and eosin staining. The fluorescence soon spread to involve the entire epithelium, followed by desquamation coinciding with the onset of manifest illness. Pneumonia was seen in some of the infected ferrets, and in them, viral antigens were found in the bronchial epithelium and in the mediastinal lymph nodes. A rise of viral infectivity titer paralleled the observed spread of viral antigens. Many desquamated nasal epithelial cells and macrophages containing antigen were present in nasal smears. The finding would seem to offer a method for the rapid specific diagnosis of influenza infection.
Effectiveness of an influenza vaccine programme for care home staff to prevent death, morbidity, and health service use among residents: cluster randomised controlled trial
Authors: Andrew C Hayward, Richard Harling, Sally Wetten, Anne M Johnson, Susan Munro, Julia Smedley, Shahed Murad, John M Watson
Journal: BMJ (2006)

<b>Objective</b> To determine whether vaccination of care home staff against influenza indirectly protects residents. <b>Design</b> Pair matched cluster randomised controlled trial. <b>Setting</b> Large private chain of UK care homes during the winters of 2003-4 and 2004-5. <b>Participants</b> Nursing home staff (n=1703) and residents (n=2604) in 44 care homes (22 intervention homes and 22 matched control homes). <b>Interventions</b> Vaccination offered to staff in intervention homes but not in control homes. <b>Main outcome measures</b> The primary outcome was all cause mortality of residents. Secondary outcomes were influenza-like illness and health service use in residents. <b>Results</b> In 2003-4 vaccine coverage in full time staff was 48.2% (407/884) in intervention homes and 5.9% (51/859) in control homes. In 2004-5 uptake rates were 43.2% (365/844) and 3.5% (28/800). National influenza rates were substantially below average in 2004-5. In the 2003-4 period of influenza activity significant decreases were found in mortality of residents in intervention homes compared with control homes (rate difference −5.0 per 100 residents, 95% confidence interval −7.0 to −2.0) and in influenza-like illness (P=0.004), consultations with general practitioners for influenza-like illness (P=0.008), and admissions to hospital with influenza-like illness (P=0.009). No significant differences were found in 2004-5 or during periods of no influenza activity in 2003-4. <b>Conclusions</b> Vaccinating care home staff against influenza can prevent deaths, health service use, and influenza-like illness in residents during periods of moderate influenza activity. <b>Trial registration </b> National Research Register N0530147256.
Detection of Gastrointestinal Bleeding Sites
Authors: Stephen R. Bunker
Journal: JAMA (1982)

Sixteen patients clinically suspected of having gastrointestinal hemorrhage were studied by abdominal scintigraphy with RBCs labeled in vitro with technetium Tc 99m. Ten of 11 actively bleeding patients had positive scintigrams, with bleeding localized to the duodenum in one, ascending colon in five, sigmoid colon in six, and rectosigmoid colon in one. Scintigraphic findings were corroborated by clinical, endoscopic, arteriographic, and surgical findings. Retention of this blood-pool radiotracer in the vascular compartment allows noninvasive diagnosis of acute, as well as slow or intermittent, bleeding for up to 24 hours after intravenous administration. (<i>JAMA</i>1982;247:789-792)
EVALUATION OF APICAL POUCHES IN HYPERTROPHIC CARDIOMYOPATHY USING CARDIAC MRI
Authors: Kalie Yang Kebed, Raed Al Adham, Kalkidan Bishu, John Askew, Kyle Klarich, Jae Oh, Paul Julsrud, Thomas Foley, James Glockner, Steve Ommen, Rick Nishimura, Nandan Anavekar
Journal: Journal of the American College of Cardiology (2013)
A memorable patient
Authors: G. Mannes
Journal: BMJ (1996)

During their medical education doctors are taught to translate the symptoms of the patients into objective parameters in order to come to the right diagnosis. Teachers also remind their students that it is not always possible to express the facts into figures, and a good doctor should never refrain from watching and listening to the patient. In medical literature, however, figures seem to be all that matter, and it is easy to forget the old lesson.

After I had finished my training in pulmonology I became one of the doctors responsible for a new lung transplantation programme. Many things had to be learnt …
Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire
Authors: Matthew A. Burchill, Jianying Yang, Kieng B. Vang, James J. Moon, H. Hamlet Chu, Chan-Wang J. Lio, Amanda L. Vegoe, Chyi-Song Hsieh, Marc K. Jenkins, Michael A. Farrar
Journal: Immunity (2008)
Management of the Patient With Cancer
Authors: Yeu-Tsu N. Lee
Journal: JAMA (1977)

This comprehensive book contains 40 chapters written by 71 authors, including four radiotherapists and nine professors of medicine. Since it is edited by a surgical oncologist, the overall presentation and orientation emphasize surgical approaches, but the information is useful for clinicians of all disciplines. The purpose of this book, as stated in the preface of its first edition, is to make available to general physicians and surgeons the essential information important for management of cancer of all sites. This new edition certainly has updated and fulfilled its original promise. The first six chapters contain general considerations, the other 34 chapters cover cancers of specific organ sites and systems. Important information about epidemiology, pathology, clinical manifestations, differential diagnosis, treatment modality, and natural history is presented. In this second edition, 11 years after the original publication, 40% of the material is claimed to be new. The editor makes it clear that "no
Household Exposure to Paint and Petroleum Solvents, Chromosomal Translocations, and the Risk of Childhood Leukemia
Authors: Ghislaine Scélo, Catherine Metayer, Luoping Zhang, Joseph L. Wiemels, Melinda C. Aldrich, Steve Selvin, Stacy Month, Martyn T. Smith, Patricia A. Buffler
Journal: Environmental Health Perspectives (2008)

BackgroundFew studies have examined the association between home use of solvents and paint and the risk of childhood leukemia.ObjectivesIn this case–control study, we examined whether the use of paint and petroleum solvents at home before birth and in early childhood influenced the risk of leukemia in children.MethodsWe based our analyses on 550 cases of acute lymphoblastic leukemia (ALL), 100 cases of acute myeloid leukemia (AML), and one or two controls per case individually matched for sex, age, Hispanic status, and race. We conducted further analyses by cytogenetic subtype. We used conditional logistic regression techniques to adjust for income.ResultsALL risk was significantly associated with paint exposure [odds ratio (OR) = 1.65; 95% confidence interval (CI), 1.26–2.15], with a higher risk observed when paint was used postnatally, by a person other than the mother, or frequently. The association was restricted to leukemia with translocations between chromosomes 12 and 21 (OR = 4.16; 95% CI, 1.66–10.4). We found no significant association between solvent use and ALL risk overall (OR = 1.15; 95% CI, 0.87–1.51) or for various cytogenetic subtypes, but we observed a significant association in the 2.0- to 5.9-year age group (OR = 1.55; 95% CI, 1.07–2.25). In contrast, a significant increased risk for AML was associated with solvent (OR = 2.54; 95% CI, 1.19–5.42) but not with paint exposure (OR = 0.64; 95% CI, 0.32–1.25).ConclusionsThe association of ALL risk with paint exposure was strong, consistent with a causal relationship, but further studies are needed to confirm the association of ALL and AML risk with solvent exposure.
John XXI — Ophthalmologist, Professor of Physic, Pope
Authors: William B. Ober, Alvin J. Conway
Journal: New England Journal of Medicine (1965)

MANY roads lead to Rome; on one occasion a career in medicine led to the Primacy of that See. John XXI, who was pope for eight months in 1276–77, was primarily a thirteenth-century physician, scientist and philosopher whose election to the Papacy and whose death were both the result of external pressure. When Hadrian V died at Viterbo in the summer of 1276, the conclave of Cardinals to choose his successor met under the stringent rules of Gregory X. The citizenry, tired of irregularities in previous elections, were anxious to see that the rules were enforced, and enforced they were. . . .
Juniors' hours of work.
Authors: T Delamothe
Journal: BMJ (1990)

Some types of cognitive therapy-such as those used in managing personality disorders and in conditions tradition- ally seen as suitable for psychoanalytic treatment-are time consuming and require considerable experience and skill.34By contrast, in cases of anxiety, depression, and physical illness cognitive therapy is characteristically briefand focused.It not only addresses current cognitions but also teaches the patient how to deal with these more successfully in the future.Thus, cognitive therapy should have a prophylactic effect, and there is already some evidence that it does.3537And if cognitive techniques may be successfully acquired by patients they must also be accessible to general practitioners, physicians, and other specialists.They are described in treatment manuals,3839 and they offer considerable scope for improving communication between doctors and their patients.26Cognitive therapy initially developed empirically from clinical observation.One of the main strengths of the cognitive model, however, is its support and enhancement by experimental research.4142This convergence of clinical and experimental data is shown well in a recently published handbook of cognitive therapy.26Reliable data of this kind allow therapists to determine the particular cognitive factors associated with defined types of illness and so to develop specific interventions.Several studies that are testing such interventions are in progress.Their success, and the ease with which they can be applied by clinicians who are not specialists in cognitive therapy, will define more clearly the role of cognitive interventions in physical illness.
UK government consults on tackling mental health problems through group activities
Authors: O. Mashta
Journal: BMJ (2009)

Wellbeing initiatives that encourage group activities should be promoted among whole communities in a bid to prevent mental health problems, according to the government’s consultation document on the future of mental health policy.

The document, New Horizons , sets out a new approach to tackling mental health problems by focusing on prevention as well as treatment.

Urban allotments, reading groups, and computer training for people older than 50 are just some of the initiatives highlighted in the document.

Launching the document on 23 July the care services minister, Phil Hope, said, “People with mental health problems are more likely to do other things that damage their health, such as have a poor diet, smoke, or take drugs. So promoting good mental health is a key part of tackling many other health inequalities.

“Our aim …
1091. Successful Induction of Immune Tolerance to Canine Factor VIII after Lentiviral-Mediated Gene Therapy in Neonatal Hemophilia A Mice
Authors: Hideto Matsui, Masaru Shibata, Brian Brown, Andrea Labelle, Carol Hegadorn, Chandler Andrews, Marinee Chuah, Thierry VandenDriessche, Carol H. Miao, Christine Hough, David Lillicrap
Journal: Molecular Therapy (2006)

The development of neutralizing antibodies (inhibitors) directed against Factor VIII (FVIII) is currently the most significant complication associated with FVIII replacement therapy in hemophilia A patients and presents a considerable obstacle to successful gene therapy strategies. Induction of immunological tolerance (ITI) to FVIII involves frequent intravenous infusions of FVIII according to various therapeutic regimens, and has been successful in many inhibitor-positive patients. However, ITI is not successful in all patients and it requires frequent intravenous access and is very expensive. Alternative methods of inducing tolerance to the FVIII protein may prove beneficial especially if this can be achieved prior to inhibitor development. With a view to utilizing the potential of neonatal immune-privilege, we administered canine-FVIII expressing lentiviral vectors prior to FVIII protein challenge. The lentiviral vector, hAAT-cFVIII-LV, contained a B domain-deleted canine FVIII transgene under the control of a liver specific promoter. 1x108 Transducing Units (TU)/mouse were administrated to 0-1 day old Balb/c hemophilia A neonates either intravenously (IV), intraperitoneally (IP) or subcutaneously (SC). Neutralizing anti- canine FVIII antibodies developed in all mice treated with IP or SC injection, In contrast, FVIII activity (range <10-1586.7mU/mL) was detected for greater than 3 months in 8/13 mice treated intravenously and all mice failed to develop high-titer neutralizing anti-FVIII antibodies. To evaluate long-term tolerance induction following this protocol, 3 of these mice were challenged, 52 weeks post-hAAT- cFVIII-LV treatment, with four intravenous infusions of 0.2ug recombinant canine FVIII (rcFVIII) protein (80U/kg). Splenocytes were isolated, cultured and in vitro cytokine production and T cell proliferation, was assessed. Treated mice injected with rcFVIII remained inhibitor negative and this tolerance was accompanied by increased in vitro T cell production of IL-10 in parallel with decreased production of IL-6 and IFN-γ in vitro. The splenocytes from these tolerant mice are capable of transferring tolerance to naïve recipient hemophilia A Balb/c mice indicating that the mechanism underlying this phenomenon likely involves regulatory T lymphocytes.
Arterial wall characteristics determined by intravascular ultrasound imaging: An in vitro study
Authors: Elma J. Gussenhoven, Catherina E. Essed, Charles T. Lancée, Frits Mastik, Peter Frietman, Frans C. van Egmond, Johannes Reiber, Hans Bosch, Hero van Urk, Jos Roelandt, Nicolaas Bom
Journal: Journal of the American College of Cardiology (1989)
Economic Outcomes of Implantable Cardioverter-Defibrillators
Authors: Marshall S. Stanton, Gregory K. Bell
Journal: Circulation (2000)

Background —We reviewed the literature pertaining to the cost-effectiveness of implantable cardioverter-defibrillator (ICD) therapy in the management of ventricular fibrillation and tachycardia. Discussed are the methodology, advantages, and limitations of economic-outcomes analyses as related to ICD therapy; the impact of new technology and physician practice patterns; and methodological recommendations for future studies. Methods and Results —Articles published between 1990 and 1997 were screened for cost-effectiveness analyses of ICD versus antiarrhythmic drug therapy. Randomized clinical trials, prospective and retrospective studies, and economic models were included. These studies report incremental cost-effectiveness ratios ranging from cost savings of $13 975 per life-year saved (LYS) to an incremental cost of $114 917 per LYS for ICD therapy. Differences were due to study type, cost-reporting methodology, ICD technology used, and length of follow-up. Assuming current technology and physician practice patterns, we find that ICD total therapy costs may break even in 1 to 3 years. Conclusions —Recent literature suggests that ICDs are a cost-effective therapy for management of life-threatening ventricular tachyarrhythmias. The advent of new technology and patient management practices should further improve the cost-effectiveness of ICD therapy. Future studies of ICD cost-effectiveness should address the implications of truncated follow-up periods and quality of life.
Mutagenic activity of disinfection by-products.
Authors: L Cognet, Y Courtois, J Mallevialle
Journal: Environmental Health Perspectives (1986)

Data on raw water quality, disinfection treatment practices, and the resulting mutagenic properties of the treated water were compiled from pilot- and full-scale treatment experiments to evaluate that parameter which might produce variability in the results of a mutagenic study. Analysis of the data and comparison of treatment practices indicated that the measured mutagenic activity is strongly related to the characteristics of the organic matter in the raw water, the methodology used to sample and detect mutagens, the scale of the study both in terms of treatment flow and period of study, and the point at which and the conditions under which oxidants are added during treatment. Conclusions regarding disinfection systems in full-scale water treatment plants include the following: When raw water is pretreated and high concentrations of organics are present in the raw water, both ozonation and chlorination increased mutagenic activity. However, no significant difference in mutagenicity was found between the two oxidants. Both in the case of a nitrified groundwater and a clarified surface water, the mutagenic activity of the water after ozonation was related to its mutagenic activity before ozonation. With ozonation, mutagenic activity decreased after granular activated carbon (GAC) filtration. Thus, when GAC filtration follows ozone disinfection, early addition of oxidants may not be deleterious to the finished water quality. When chlorine or chlorine dioxide is added after GAC filtration, chlorine dioxide was found to produce a less mutagenic water than chlorine. Although these conclusions suggest means of controlling mutagenic activity during treatment, it must be stressed that the measurement of mutagenicity is a presumptive index of contamination level.
Mental disorders common among US children, CDC says
Authors: M. McCarthy
Journal: BMJ (2013)

As many as one in five US children suffers from a mental disorder in a given year, according to a new report from the US Centers for Disease Control and Prevention (CDC).

The article, “Mental health surveillance among children—United States, 2005-2011,” which was published as a supplement of the 17 May issue of Morbidity and Mortality Weekly Report ( MMWR ), is the first comprehensive report on children’s mental health in the US, the CDC said.

The report summarizes information gathered from a wide variety of federal surveillance programs, including those of the CDC, the Health Resources and Services Administration, and the Substance …
Fatal Exfoliative Dermatitis after Sulfamethoxypyridazine
Authors: Carl D. Strouse
Journal: New England Journal of Medicine (1961)

THE sulfonamide drugs are known to be potentially toxic and are capable of causing exfoliative dermatitis. One of these, sulfamethoxypyridazine, has been used recently with good results and low toxicity. It has the advantage of prolonged blood levels with low dosage and has been used most for urinary-tract infections.1 2 3 4 Unfavorable reactions involving fever and urticaria,5 headache, anorexia and sore throat,6 thrombocytopenic purpura,7 , 8 myocarditis9 and aplastic anemia10 have been reported.Cutaneous reactions are reported as a regular complication of the use of sulfamethoxypyridazine,11 , 16 but I have found only 1 reported case of exfoliative dermatitis attributable to this drug.17 Case ReportAn . . .
Trypanosomiasis in a European treated with Pentamidine
Authors: R. R. Bomford
Journal: BMJ (1944)

Routine gargling had no effect in reducing the carrier rate during the epidemic.A comparison is made with a similar type of outbreak which occurred in an American Army camp.I wish to tender thanks to Dr. N. Crowley for the help she gave me in the bacteriological investigation of throat swabs, etc.
XIII. Acute Cardiac Decompensation
Authors: Joseph V. Messer
Journal: New England Journal of Medicine (1966)

ACUTE cardiac decompensation, a clinical syndrome of considerable variability, may have several causes. Successful management of this common syndrome requires accurate etiologic diagnosis and a clear understanding of the cardiovascular pathophysiology upon which effective therapy is based. A pathophysiologic description is beyond the scope of this presentation, and is available in several excellent reviews.1 2 3 Adequate management of acute cardiac decompensation demands a keen awareness of the rapidity with which its various manifestations can emerge–as a reflection of the underlying cause or in response to therapy. Thus, acute cardiac decompensation may first present as sudden agitation and anxiety without easily detectable . . .