tbuckley/cabot-search huggingface dataset:
Impact of Extratumoral Lymphatic Permeation on Postoperative Survival of Non–Small-Cell Lung Cancer Patients
Authors: Yuki Matsumura, Tomoyuki Hishida, Yoshihisa Shimada, Genichiro Ishii, Keiju Aokage, Junji Yoshida, Kanji Nagai
Journal: Journal of Thoracic Oncology (2014)

Lymphatic permeation has been reported as a prognostic factor for patients with resected non-small-cell lung cancer (NSCLC). Lymphatic canals are located in both intratumoral and extratumoral areas. Since 2001, we have prospectively evaluated lymphatic permeation based on its location. The purpose of this study was to determine the survival impact of extratumoral lymphatic permeation in patients with resected NSCLC by analyzing the long-term follow-up data.We reviewed 1069 consecutive patients with NSCLC who underwent complete resection between 2001 and 2006. Lymphatic permeation was classified as follows: ly0, absence of lymphatic permeation; ly1, intratumoral; and ly2, extratumoral.There were 845 patients (79%) with ly0, 134 (12%) with ly1, and 90 (9%) with ly2. Ly2 was more frequently observed in patients with advanced disease and intrapulmonary metastases than ly0-1. The 5-year overall survival (OS) rates of the ly0, ly1, and ly2 groups were 75%, 63%, and 34%, respectively. The OS rate was significantly worse in the ly2 group compared with OS rate in the ly0 (p < 0.01) and ly1 groups (p < 0.01). In multivariate analyses, ly2 proved to be an independent poor prognostic factor (hazard ratio, 1.73; p < 0.01). OS and recurrence-free survival of patients with T1 and T2 tumors with ly2 were not statistically different from that of the patients with T3 tumor (OS, p = 0.43 and p = 0.77; recurrence-free survival, p = 0.94 and p = 0.94, respectively).The adverse prognostic impact of lymphatic permeation was remarkably different whether it is detected in intratumoral or extratumoral lymphatic canals. We recommend that lymphatic permeation in resected NSCLC should be evaluated by considering its location.
Abstract 1684: The potential role of HER3 on HER2-driven biliary carcinogenesis and the possibility for targeted therapy with pertuzumab
Authors: Toru Kawamoto, Ken-ichiro Onuki, Hiroaki Sugiyama, Melanie Thomas, Yoriko Yamashita-Kashima, Sei Shu, Naoki Harada, Kaori Fujimoto-Ouchi, Shun-ichi Ariizumi, Masakazu Yamamoto, Jun-ichi Shoda
Journal: Cancer Research (2012)

Abstract HER2 has been implicated in biliary carcinogenesis, because gene amplification of HER2 has been observed in 20% of gallbladder carcinoma (GBC) (Kawamoto, et al. GCR 2007). The first-in-class HER2 dimerization inhibitor (HDI) pertuzumab is a humanized monoclonal antibody that binds HER2 at an epitope that prevents HER2 from dimerizing with ligand-activated HER family receptors, In this study, we determined the expression of HER family proteins in GBC, cholangiocellular carcinoma(CC), and examined whether treatment with pertuzumab would affect GBC and CC cell lines. Methods: HER family expression was examined in surgical or biopsied specimens from 47 GBCs and 57 CCs by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). Using 6 GBC and 8 CC cell lines, heregulin-stimulated cell proliferation and its inhibition by pertuzumab, were tested in vitro by MTT assay. The phosphorylated HER family proteins and their respective downstream molecules were examined by Western blot analysis. Anti-tumor activity of pertuzumab in vivo was evaluated in the CC cell line KMCH-1 xenograft model with weekly intraperitoneal administration. Results: Over-expression of HER2 or HER3 was observed in 14-34% of all patients (Table 1). Six of 14 cell lines demonstrated over-expression of both HER2 and HER3, and heregulin stimulation increased the proliferation in 3 of them. In the HER2- and HER3- over-expressing KMCH-1, pertuzumab significantly inhibited cell proliferation in a dose-dependent manner. Pertuzumab completely blocked heregulin-induced phosphorylation of HER3. Furthermore, suppression of downstream pathway molecules including pAKT and pS6 were observed. The xenograft model also revealed tumor growth inhibition with pertuzumab. Conclusions: Pertuzumab demonstrated significant antitumor activities in HER2 and HER3 over-expressing cancer cells. Thus, pertuzumab may provide a new therapy option for both HER2- and HER3- positive GBC and CC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1684. doi:1538-7445.AM2012-1684
Chylous ascites in Kaposi's sarcoma: a case report
Authors: K.M. FIFE, D.C. TALBOT, P. MORTIMER, C. ISHER, I.E. SMITH
Journal: British Journal of Dermatology (1992)

We report a case of a patient with Kaposi's sarcoma (KS), massive chylous ascites and chylous pleural effusions. This association has not been reported previously. The pathogenesis of chylous effusions is discussed with respect to KS.
A Comparison of Aged Solution of Alkali-Treated Penicillin and Commercial Penicillin Skin Testing Kit in the Diagnosis of Patients with a History of Penicillin Allergy
Authors: P. Wangrattanasopon, K. Ruxrungthum, H. Chantaphakul, J. Klaewsongkram
Journal: Journal of Allergy and Clinical Immunology (2010)
Ischemic cardiomyopathy: Endomyocardial biopsy and ventriculographic evaluation of patients with congestive failure, dilated cardiomyopathy and coronary artery disease
Authors: Joshua M. Hare, Gary D. Walford, Ralph H. Hruban, Grover M. Hutchins, Jaap W. Deckers, Kenneth L. Baughman
Journal: Journal of the American College of Cardiology (1992)
Infiltration of plasma rich in growth factors enhances in vivo angiogenesis and improves reperfusion and tissue remodeling after severe hind limb ischemia
Authors: Eduardo Anitua, Beatriz Pelacho, Roberto Prado, José Javier Aguirre, Mikel Sánchez, Sabino Padilla, Xabier L. Aranguren, Gloria Abizanda, María Collantes, Milagros Hernandez, Ana Perez-Ruiz, Ivan Peñuelas, Gorka Orive, Felipe Prosper
Journal: Journal of Controlled Release (2015)
Diagnosing Endocarditis in Patients With<i>Staphylococcus aureus</i>Bacteremia
Authors: Matthew Schoenfeld, Raj Machhar, Anna Maw
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relationship of Periodontal Status and Dental Caries Status with Oral Health Knowledge, Attitude and Behavior among Professional Students in India
Authors: Archana J Sharda, Srinath Shetty
Journal: International Journal of Oral Science (2009)

To find the relationship of periodontal status and dental caries status with oral health knowledge, attitude, behavior, among professional students in India. In a cross sectional study, a total of 825 students (males: 577, females: 248) from six professions were surveyed using a self administered structured questionnaire including 41 multiple choice questions and the WHO Oral Health Assessment Form (1997). The data was analyzed using the SPSS version 13.0 to perform the Student's t‐test, ANOVA test, Scheffe's test and Chi‐square test, linear regression analysis. The mean percentage scores of the students for knowledge were 53.25 ± 15.05; for attitude 74.97 ±20.48; and for behavior 59.09 ± 18.77. The percentage of students with calculus score was found to be significantly high (43.8%). The percentage of professional students with DMFT>4 was 14.1% and the percentage of students with decayed teeth was 46.2%. The regression analysis showed that the oral health behavior of the students was dependent on the attitude (P <0.001), but showed no significant linear relation with the knowledge. Also, that the mean DMFT score was dependent on the oral health behavior (P <0.05), but showed no significant relationship with the knowledge and attitude of the students. The periodontal status was independent on the knowledge, but showed a significant relationship with attitude and behavior of the students. A positive attitude and adherence to good oral hygiene behaviors is associated with better oral health.
The 2012 West Nile Encephalitis Epidemic in Dallas, Texas
Authors: Wendy M. Chung, Christen M. Buseman, Sibeso N. Joyner, Sonya M. Hughes, Thomas B. Fomby, James P. Luby, Robert W. Haley
Journal: JAMA (2013)

After progressive declines over recent years, in 2012 West Nile virus epidemics resurged nationwide, with the greatest number of cases centered in Dallas County, Texas.To analyze the epidemiologic, meteorologic, and geospatial features of the 2012 Dallas West Nile virus epidemic to guide future prevention efforts.Public health surveillance of Dallas County, an area of 2257 km2 and population of 2.4 million. Surveillance data included numbers of residents diagnosed with West Nile virus infection between May 30, 2012, and December 3, 2012; mosquito trap results; weather data; and syndromic surveillance from area emergency departments.Incidence and age-adjusted incidence rates of West Nile neuroinvasive disease (WNND), daily prevalence of emergency department visits for asthma and skin rash, and Culex quinquefasciatus species-specific vector index (an estimate of the average number of West Nile virus-infected mosquitoes per trap-night).The investigation identified 173 cases of WNND, 225 of West Nile fever, 17 West Nile virus-positive blood donors, and 19 deaths in 2012. The incidence rate for WNND was 7.30 per 100,000 residents in 2012, compared with 2.91 per 100,000 in 2006, the largest previous Dallas County outbreak. An unusually rapid and early escalation of large numbers of human cases closely followed increasing infection trends in mosquitoes. The Cx quinquefasciatus species-specific vector index predicted the onset of symptoms among WNND cases 1 to 2 weeks later (count regression β = 2.97 [95% CI, 2.34 to 3.60]; P < .001). Although initially widely distributed, WNND cases soon clustered in neighborhoods with high housing density in the north central area of the county, reflecting higher vector indices and following geospatial patterns of West Nile virus in prior years. During the 11 years since West Nile virus was first identified in Dallas, the log-transformed annual prevalence of WNND was inversely associated with the number of days with low temperatures below 28°F (-2.2°C) in December through February (β = -0.29 [95% CI, -0.36 to -0.21]; P < .001). Aerial insecticide spraying was not associated with increases in emergency department visits for respiratory symptoms (β = -4.03 [95% CI, -13.76 to 5.70]; P = .42) or skin rash (β = -1.00 [95% CI, -6.92 to 4.92]; P = .74).Large West Nile virus epidemics in Dallas County begin early after unusually warm winters, revisit similar geographical distributions, and are strongly predicted by the mosquito vector index. Consideration of weather patterns and historical geographical hot spots and acting on the vector index may help prevent West Nile virus-associated illness.
Health Checks — Oxford vs. Cambridge
Authors: John Lister
Journal: New England Journal of Medicine (1958)

THE routine health check so often demanded by the business executive or by his board of directors has recently been under fire. The controversy arose after the British Broadcasting Corporation announced its intention of having periodical medical examinations carried out on its senior executives, the purpose of the examination being "to discover in time any evidence of oncoming illness so that appropriate action may be taken to forestall a breakdown in health."A number of practicing physicians, in letters to the Times, expressed doubts about the value of such examinations and pointed out that it is only rarely possible . . .
IMMUNE AND NATURAL ANTIBODIES TO SYNGENEIC MURINE PLASMA CELL TUMORS
Authors: Ronald B. Herberman, Tadao Aoki
Journal: The Journal of Experimental Medicine (1972)

Cytotoxic antibody to a plasma cell tumor antigen was produced in syngeneic BALB mice by immunization with viable or inactivated plasma cell tumors. Antibody with the same specificity was found in the sera of normal BALB and other strains of mice. This natural antibody reacted with an antigen with characteristics indistinguishable from the previously described alloantigen, PC.1, and with viral envelope antigen, chiVEA. The incidence of cytotoxic reactivity and the antibody titers reached a peak in normal BALB mice at 3-4 months of age, and were lower in 9-12-month old mice. The sera of germfree mice had lower reactivity; but when the mice were transferred to conventional conditions, their sera soon became as active as those of conventional mice. A virus common to all plasma cell tumors, which is present in latent form in some normal tissues of BALB and other PC.1 positive strains, is suggested as the cause for the PC.1 antigen and for the appearance of natural antibody to it. The considerable evidence for the close association of a virus with plasma cell tumors is presented.
Helping poorer countries make locally informed health decisions
Authors: K. Chalkidou, R. Levine, A. Dillon
Journal: BMJ (2010)

Health spending in low income countries is too often driven by outside pressure rather than local evidence. <b>Kalipso Chalkidou</b>, <b>Ruth Levine</b>, and <b>Andrew Dillon</b> report on efforts to help them match spending to local needs
A universal definition of ARDS: the PaO2/FiO2 ratio under a standard ventilatory setting—a prospective, multicenter validation study
Authors: Jesús Villar, Lina Pérez-Méndez, Jesús Blanco, José Manuel Añón, Lluís Blanch, Javier Belda, Antonio Santos-Bouza, Rosa Lidia Fernández, Robert M. Kacmarek
Journal: Intensive Care Medicine (2013)
Comparative efficacy and tolerability of pharmacological treatments in the maintenance treatment of bipolar disorder: a systematic review and network meta-analysis
Authors: Tomofumi Miura, Hisashi Noma, Toshi A Furukawa, Hiroshi Mitsuyasu, Shiro Tanaka, Sarah Stockton, Georgia Salanti, Keisuke Motomura, Satomi Shimano-Katsuki, Stefan Leucht, Andrea Cipriani, John R Geddes, Shigenobu Kanba
Journal: The Lancet Psychiatry (2014)
The Combination of Octreotide and Midodrine Is Not Superior to Albumin in Preventing Recurrence of Ascites After Large-Volume Paracentesis
Authors: Khurram Bari, Cecilia Miñano, Martha Shea, Irteza B. Inayat, Hashem J. Hashem, HoChong Gilles, Douglas Heuman, Guadalupe Garcia–Tsao
Journal: Clinical Gastroenterology and Hepatology (2012)
Hue opponency: A constraint on colour categorization known from experience and experiment
Authors: John S. Werner, Michelle L. Bieber
Journal: Behavioral and Brain Sciences (1997)

The terms red, green, yellow, and blue are both necessary and sufficient to describe our chromatic experience. Their uniqueness and opponent nature is supported by evidence obtained under supra- threshold conditions, especially hue cancellation. These constraints are nontrivial. How some electrophysiologically identified mechanisms contribute to colour appearance is not known, but their complexities do not refute our experience of elemental hues.
High IgE Reactivity to Subunit G5 from the Soybean Legumin Allergen Gly m 6 in Sera from Soy Allergic Japanese Children
Authors: S. Sjolander, F. Bernhardsson, P. Brostedt, M. Borres, A. Tanaka, K. Ito, M. Ebisawa, S. Utsumi, M. Poorafshar
Journal: Journal of Allergy and Clinical Immunology (2010)
957 Effect of chronic hepatitis B infection on dendritic cell (DC) function: impaired antigen presentation by myeloid DC and reduced IFN-α production by plasmacytoid DC
Authors: R VANDERMOLEN, D SPRENGERS, R BINDA, E DEJONG, J KUSTERS, J KWEKKEBOOM, H JANSSEN
Journal: Hepatology (2003)

A novel variant of the HLA-DR13 group is described. The new allele was found in a DR 10, 13 heterozygous patient of Turkish origin, two HLA genotypically identical children of the patient typed as DR11, 13, and one child typed as DR13, 13. DR13 subtyping of the patient was initially performed by SSCP analysis of PCR-amplified DNA, using the 11th IHWS primers DRBAMP-3 and DRBAMP-B. Due to an unusual SSCP banding pattern, the PCR product was subjected to solid-phase sequencing. The sequence of the new allele, DRB1∗1314, is different from that of DRB 1∗1307 by a single nucleotide substitution in codon 47, with T replacing consensus A. This results in a single amino acid change of tryptophan to phenylalanine in the first domain of the DRβ chain.
Idiopathic ulcerative colitis in the African: a report of 4 cases.
Authors: J. R. Billinghurst, J. M. Welchman
Journal: BMJ (1966)

The results of treating 96 patients suffering from trigeminal neuralgia with carbamazepine (Tegretol) are given.Of these patients 68% did well on the drug, and were kept comfortable for periods up to two and a half years.
INDUCED VARIATIONS IN THE AGGLUTIN-ABILITY OF BACILLUS TYPHOSUS
Authors: FREDERICK P. GAY
Journal: JAMA (1913)

It is well recognized that strains of the typhoid bacillus vary in the readiness with which they are clumped by a typhoid patient's serum, or even by a typhoid immune serum. These variations in agglutinability are so marked in freshly isolated strains of the microorganism that not infrequently it is impossible to identify them as true typhoid bacilli even by the use of potent immune serums until they have been grown for several generations on culture mediums. This failure in immediate identification at best delays diagnosis and has at times led to error.<sup>1</sup>The following observations made in connection with an extended study on the comparative immunizing value of various preparations of the typhoid bacillus offer some explanation of the inagglutinability of freshly isolated cultures, and suggest a possible means of avoiding it. As a means of testing the efficacy of various methods of immunization, we have made use
Vertebral osteomyelitis due to Staphylococcus warneri.
Authors: K T Karthigasu, R A Bowman, D I Grove
Journal: Annals of the Rheumatic Diseases (1986)

We report a case of vertebral osteomyelitis in a diabetic woman. This appears to be the first report of such an infection with the coagulase negative staphylococcus, S warneri.
Age-related maturation of the nasal immune system in children
Authors: I.J. Van Benten, C.M. Van Drunen, B.C. Van Middelkoop, L.P. Koopman, B.G.M. Niesters, W.C.J. Hop, A.D.M. Osterhaus, H.J. Neijens, W.J. Fokkens
Journal: Journal of Allergy and Clinical Immunology (2003)
USEFULNESS OF ECHOCARDIOGRAPHY IN EARLY DETECTION OF GLOBAL AND REGIONAL LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: Seungpyo Hong, Jayoung Son, Byoungkyu Kim, Byungho Kim, Youngsoo Lee, Jinbae Lee, Jaekean Ryu, Jiyoung Choi, Sunggug Chang, Keesik Kim
Journal: Journal of the American College of Cardiology (2012)
Neutral-lipid storage disease: a new disorder of lipid metabolism.
Authors: I Chanarin, A Patel, G Slavin, E J Wills, T M Andrews, G Stewart
Journal: BMJ (1975)

fetal breathing movements; but further control studies will have to be done to exclude the possibility of the degree of inhalation varying with the type of cigarette.Cigarette smoking in pregnancy is suspected of being detri- mental to the fetus.Statistical surveys have shown that the babies are smaller at birth (Butler et al., 1972) and suggested an increase in prematurity and perinatal mortality.It is not easy to relate our observations on the acute effects of smoking two cigarettes to the long-term epidemiological reports.Nevertheless, physiological factors such as hypoxia and hypoglycaemia, which might be expected to have a detrimental effect on the fetus, also reduce the normal incidence of fetal breathing movements in animals and man (Boddy and Dawes, 1975; Boddy et al., 1975).Whether the similar effect of cigarette smoking is to be inter- preted in the same way is as yet a matter for conjecture.The size of the transient change observed (see fig.) was less than the normal diurnal variation in the incidence of fetal breathing.We make this report because clinical physiologists and obstetricians in several countries are beginning to use fetal breathing movements as an index of health.These observations are best made some hours after the last cigarette has been smoked to exclude the acute effects of this variable.This work was carried out with the aid of a
WIT AND SCHIZOPHRENIC THINKING
Authors: MAX LEVIN
Journal: American Journal of Psychiatry (1957)

Many jokes are identical in structure with the thinking errors of the psychotic, a fact of biological significance. The function of play is best seen in the animal young. The kitten plays by stalking the tail of its litter mate and pouncing on it. Play thus sharpens the coordination of eye and limb, perfecting the skills of a predator and fitting the animal to survive. In man adaptation demands keen judgment. Man must be able to think logically, to associate ideas properly. Nature has made it pleasurable for the child to "play" with ideas, to put them together in various combinations and see what makes sense and what doesn't. This play with ideas, which developes the appreciation of absurdity, gives the child practice in the art of thinking and thus adds to his capacity for adaptation.
Coping With Caps
Authors: Sam Vee
Journal: JAMA (1981)

The list of iatrogenic diseases may be longer than that of "natural" ones. No tabulation is available to settle the question. It is certain, however, that the number of iatrogenic agents is increasing at a faster rate than that of naturally occurring pathogens. Diagnostic and therapeutic radiation, pharmaceutical agents, physiotherapy, and even jogotherapy are fraught with iatrogenic repercussions, and don't forget the psychic disturbances caused by physicians who frighten their patients out of their wits. Ironically, iatrogenic complications may result from well-intended measures to prevent other complications. For example, new medicine bottle caps demand artful opening and closing. This tactic keeps drugs out of reach of children. But what does it do to the adult with coronary heart disease or arthritis or both? We can visualize him, straining his eyes to read the directions on the bottle cap of his medicine bottle. Having finally deciphered the script and committed to