tbuckley/cabot-search huggingface dataset:
Two Cases of Vitiligoidea
Authors: W. Foster
Journal: BMJ (1852)

ment spoken of, fresh skin began to form, so that when it was again healed, there was very tolerable motion of the arm.I bave not had many opportunities of trying rupture of contracted parts, but in one other case where the contraction occurred in front of the elbow-joint, the same means were adopted, and with much success.Should 1 have cases of a like kind to treat, I sholuld feel disposed to follow out the plan; at the same time I would, for two or three obvious causes, limit its employ- ment to recent cases.There also seems to be no reason why the same principle should not guide the knife in cases of this description.Instead of dissecting the cicatrix, or dividing it, as is usually done, I would make incisions in different directions, and even leave small detached portions of integument, and thus imit.e what occurs when the parts are ruptured by force.Each promontory or isolated portion of integument becomes as it were a spring, from which new matter is formed.This suggestion, however, requires to be practised, ere its efficacy can be fully established, and I probably shall practise it in a case now under my treatment, and give the results to the profession.
Abstract 3756: Structure activity relationship studies of novel FAK inhibitor C4
Authors: Priyanka A. Agharkar, Manivannan Ethirajan, Jianqun Liao, Michael Yemma, William Cance, Ravindra Pandey, Elena Kurenova
Journal: Cancer Research (2012)

Abstract Introduction: FAK and VEGFR3 have stirred considerable interest in recent years as attractive anti-cancer targets, owing to their high expression across several tumor types and relatively low levels in normal tissues. Our lab has shown that VEGFR3 binds to FAK and the physical interaction between the two proteins confers a significant survival advantage to tumor cells. We discovered small molecule C4 that specifically targets and disrupts FAK-VEGFR3 interaction to exert anti-tumor effects, but does so at moderate concentrations. This prompted us to design C4 analogs that display enhanced potency, minimum toxicity and high specificity for the target site. Here, we have shown that some C4 analogs disrupt FAK-VEGFR3 interaction and dramatically inhibit pancreatic tumor growth at low concentrations as single agents as well as in combination with Gemcitabine. Methods: The structure of C4 was modified at various positions by substituting alkyl and aryl moieties. The resulting analogs were screened for anti-cancer inhibitory effects in different cancer cell lines by MTS assay. Effects of C4 analogs on pancreatic cancer cell lines were determined by MTS assay (viability), Clonogenecity assay, Western blot (phosphorylation, apoptosis) and TUNEL assay. Target specificity (immunoprecipitation) and binding confirmation (Forte-Bio's Octet Red assay) of all analogs were performed. In vivo anti-tumor activity of lead analogs was done using a subcutaneous xenograft mouse model of pancreatic cancer. Results: Twenty C4 analogs were screened and four were selected for further analyses. These four analogs strikingly decreased survival of six pancreatic cancer cell lines. Analog C9 showed highest cytotoxic effects, inhibited colony formation of Panc-1 cells at 1µM, induced dose dependent cleavage of caspase-3 and PARP and decreased phosphorylated forms of Akt and Erk within 24h treatment. Disruption of FAK-VEGFR3 interaction was seen with 1µM C9. Octet method revealed that 20µM C9, KD (M) = 1.29×10-7. In vivo, 30 days treatment with low doses of the four analogs led to massive reduction in tumor growth when treated as single agents (60%) and in combination with Gemcitabine (80%)(P&amp;lt;0.05). Conclusions: Targeting the FAK-VEGFR3 protein-protein interaction site highlights a unique approach for molecular-targeted highly specific cancer therapeutics. The outcomes from this project could potentially widen the spectrum of oral-based treatment options for pancreatic cancer, which yet remains a formidable disease. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3756. doi:1538-7445.AM2012-3756
Out-of-Hospital Transcutaneous Pacing by Emergency Medical Technicians in Patients with Asystolic Cardiac Arrest
Authors: Richard O. Cummins, Judith Reid Graves, Mary Pat Larsen, Alfred P. Hallstrom, Thomas R. Hearne, John Ciliberti, Ray M. Nicola, Stanley Horan
Journal: New England Journal of Medicine (1993)

Transcutaneous cardiac pacemakers generate electrical stimuli that pace the heart through external electrodes that adhere to the chest wall. Transcutaneous pacing has been useful in some patients with bradycardia, but its efficacy in patients with asystole and full cardiac arrest has been limited, possibly because of delays in the initiation of pacing. We studied the efficacy of early transcutaneous pacing in patients with out-of-hospital asystolic cardiac arrest.For three years we provided transcutaneous pacemakers to about half the fire districts in a large emergency-medical-services system (the intervention group). In these districts, we authorized emergency medical technicians (EMTs) to begin transcutaneous pacing in patients with cardiac arrest and primary asystole or post-defibrillation asystole. Pacing was done as early as possible, before endotracheal intubation or intravenous medication. EMTs in the other fire districts (the control group) treated similar patients with basic cardiopulmonary resuscitation but without transcutaneous pacing.The EMTs in the intervention group initiated transcutaneous pacing in 112 of the 278 patients with primary asystole. Of these patients, 22 (8 percent) were admitted to the hospital, and 11 (4 percent) were discharged. Among the 259 patients treated by the EMTs in the control group, 21 (8 percent) were admitted to the hospital, and 5 (2 percent) were discharged. The two groups did not differ significantly with respect to the rate of hospital admission or survival. Survival after early pacing for post-defibrillation asystole was no better than survival after pacing for primary asystole.Transcutaneous pacing appears to offer no benefit in patients with asystolic cardiac arrest, even when it is performed as early as possible by EMTs in the field. Our data suggest that the widespread implementation of early transcutaneous pacing for out-of-hospital asystolic cardiac arrest would be ineffective.
More on Ripping vs Binding
Authors: RALPH G. ROBINSON
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 January 1970More on Ripping vs BindingRALPH G. ROBINSON, M.D.RALPH G. ROBINSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-1-148_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the July 1969 issue, Dr. Deaton has taken exception to your recent layout innovation regarding starting articles on a separate leaf. In response to your question, I am a binder of the ANNALS. But I am, conversely, a ripper of journals in general, and it seems that one good article is frequently followed by another, which creates a problem when they share the same page; and the separate page idea certainly makes for a neater format.However, more important is the question regarding the "filler" so easily cast aside by Dr. Deaton. God knows we have... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Kansas University Medical Center Kansas City, Kan. 66103 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTotal Syntheses 1 January 1970Volume 72, Issue 1Page: 148-148 Issue Published: 1 January 1970 PDF downloadLoading ...
Radiographic and Scintigraphic Demonstration of Mono-ostotic Fibrous Dysplasia of the Skull Advantage of SPECT Imaging
Authors: RUTH HARDOFF, SARA GIPS
Journal: Clinical Nuclear Medicine (1991)

Fibrous dysplasia is a skeletal developmental anomaly of bone-forming mesenchyma in which osteoblasts fail to undergo normal morphologic differentiation and maturation. A variety of endocrine abnormalities, including the McCune-Albright syndrome, may accompany the osseous abnormalities. The skeletal manifestation may be associated with either solitary or multiple lesions. Approximately 70% to 80% of the cases are mono-ostosic and locate mainly in the rib, femur, gnathic bone, calvarium, and humerus, and patients are frequently asymptomatic. Skull involvement occurs in 10% to 50% of patients with the mono-ostotic type, affecting the frontal, sphenoid, maxillary, temporal, and ethmoid bones. The most common radiographic manifestation is a hazy, radiolucent lesion associated with widened diploic spaces, filled with amorphous material. The surrounding bone is thin and sclerotic. Limited mono-ostotic fibrous dysplasia progresses slowly and has a favorable prognosis. Two patients, an adult and an adolescent, had mono-ostotic cranial fibrous dysplasia. In one patient, planar bone scintigraphy failed to detect the cranial lesion that was demonstrated by SPECT. In the other, SPECT imaging accurately defined the site and extent of the lesion, which could not be evaluated by the planar skull imaging. The authors conclude that SPECT bone scintigraphy serves as an adjunct to CT by demonstrating the osteo-blastic activity of the lesion, while the whole body planar imaging assesses either the unifocality or the multifocality of the disease.
BLOOD CHOLESTEROL STUDIES IN MENTAL DISEASE
Authors: Purcell G. Schube
Journal: American Journal of Psychiatry (1932)

There have been presented the total blood cholesterol estimations, as measured in 100 cc. of whole blood, in 54 normal individuals and in 200 individuals not normal from a neuropsychiatric point of view. These two types of cases were considered as two distinct groups and the material evaluated accordingly. The evaluation of the results was carried out by means of a statistical procedure. The author wishes to acknowledge his appreciation of the assistance of Dr. George S. Johnson, Acting Director of the Colorado Psychopathic Hospital; Robert C. Challman, psychologist; and Miss Rachel D. Frame, in the preparation of the manuscript.
LIFE OF SIR LAUDER BRUNTON
Authors: T. B. Scott
Journal: BMJ (1919)

<h3>Abstract</h3> <h3>Objectives</h3> Post-COVID syndrome remain poorly studied in children and adolescents. In this study, we aimed to investigate the prevalence and risk factors of pediatric post-COVID in a population-based sample, stratifying by serological status. <h3>Study design</h3> We used data from the SEROCoV-KIDS cohort study (State of Geneva, Switzerland), which included children (aged 6 months to 17 years) selected from random samples drawn from state registries or who had a household member participating in a COVID-19 seroprevalence study conducted by our group. Children were tested for anti-SARS-CoV-2 N antibodies. Parents filled in a questionnaire on persistent symptoms in their children (lasting over 12 weeks) compatible with post-COVID syndrome. <h3>Results</h3> From December 1<sup>st</sup>, 2021 to February 16<sup>th</sup>, 2022, 1034 children were included, among whom 570 (55.1%) were seropositive. The sex- and age-adjusted prevalence of persistent symptoms among seropositive children was 9.1% (95%CI: 6.7;11.8) and 5.0% (95%CI: 3.0;7.1) among seronegatives, with an adjusted prevalence difference (ΔaPrev) of 4.1% (95%CI: 1.1;7.3). After stratification by age group, the prevalence was higher among adolescents aged 12-17 years (ΔaPrev=8.3%, 95%CI: 3.5;13.5) than among younger children (0.0%, 95%CI: −5.2;5.2 among 6-11 years old and 4.2%; 95%CI: −4.4;13.3 among 0-5 years old). The most frequently declared persistent symptoms among seropositives were smell loss, trouble concentrating and abdominal pain. Older age, having a chronic condition and lower socioeconomic conditions were identified as risk factors. <h3>Conclusion</h3> A significant proportion of seropositive children, particularly adolescents, experienced persistent symptoms. While there is a need for further investigation, growing evidence of pediatric post-COVID syndrome urges early screening and primary care management.
DNA adduct formation in the human nasal mucosa as a biomarker of exposure to environmental mutagens and carcinogens.
Authors: S Flato, K Hemminki, E Thunberg, A Georgellis
Journal: Environmental Health Perspectives (1996)

Human exposure to chemical compounds, often termed xenobiotics, has been linked to a number of enhanced incidences of various neoplasias. A majority of these enter the human body through inhalation. Most xenobiotics are metabolized in the body to more hydrophilic metabolites before excretion in the urine and bile. During this process, promutagens and procarcinogens could be activated and could interact with proteins as well as DNA to form adducts. DNA adducts formed by chemical carcinogens can, therefore, be used as biomarkers of exposure and other host factors. This study that DNA adduct analysis can be performed on cells from human nasal mucosa. Using the nasal lavage procedure performed on 20 healthy volunteers, 5 x 10(5) to 5 x 10(6) cells were obtained from which 5 to 40 micrograms DNA was isolated. DNA adducts were analyzed by the 32-P-postlabeling assay. The DNA adduct levels ranged between 1.4 and 6 adducts/10(8) nucleotides. In addition to its simplicity, the nasal lavage procedure is an inexpensive, noninvasive procedure that requires no anesthetics or special equipment. Moreover, the cells obtained are the first to come in contact with air pollutants. DNA adduct analysis from human nose mucosa cells could therefore be used to develop a technique suitable for the assessment of exposure to chemical carcinogens through inhalation.
CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XXVI. THE PROPERTIES OF SOLUTIONS OF HUMAN SERUM ALBUMIN OF LOW SALT CONTENT 12
Authors: G. Scatchard, L. E. Strong, W. L. Hughes, J. N. Ashworth, A. H. Sparrow
Journal: Journal of Clinical Investigation (1945)

Whole plasma is distributed as a dry powder in the interests of preserving its labile constitu- ents.The albumin, the -y-globulin, the fibrinogen, the thrombin, and most of the other products of plasma fractionation are prepared as dry powders and could also be distributed in the solid state.Separated from each other, purified of the en- zymes of plasma, many of them may be distributed,
Doctors' right to refuse to perform abortions
Authors: C G B Simpson
Journal: BMJ (1994)

annually by the Human Fertilisation and Embryology Authority2 included rates of multiple pregnancy and birth rates according to both the woman's age and the number of embryos transferred.Any policy allowing numerous embryos or oocytes to be replaced entails a calculated risk of multiple pregnancy.Our data support the point made by Redgment and colleagues that the principle underlying the present policy leaves room to raise the number of embryos or eggs replaced in women aged 40 and over to try to increase their pregnancy rates while keeping rates of multiple pregnancy down to what is currently acceptable in women under 40.
Disparity between Influenza Vaccination Rates and Risks for Influenza-associated Hospital Discharge and Death in Manitoba in 1982-1983
Authors: David S. Fedson, Andre Wajda, J. Patrick Nicol, Leslie L. Roos
Journal: Annals of Internal Medicine (1992)

Objective: To determine, in a defined population, the percentage of persons who were discharged from a hospital or died of influenza-associated respiratory conditions who had a health care contact during the preceding vaccination season and to determine the relation between risk status for influenza-associated hospitalization and death and influenza vaccination rates. Design: An observational study using linked-record analysis of medical claims data. Setting and Patients: A probability sample of 100 000 noninstitutionalized adults living in Manitoba in 1982 to 1983. Measurements: Analysis of medical claims for influenza vaccination and hospital discharges and deaths for influenza-associated respiratory conditions during the 1982-83 influenza vaccination season and influenza outbreak period. Results: For the population as a whole, 50% to 60% of elderly persons (≥ 65 years of age) and 30% to 40% of younger persons had one or more health care contacts during the influenza vaccination season but fewer than 10% of all persons had been discharged from a hospital. In contrast, for elderly persons hospitalized with respiratory conditions during the influenza outbreak period, approximately 80% had at least one health care contact during the vaccination season. Among the elderly, 39% to 46% of all those discharged for influenza-associated respiratory conditions and 62% to 67% of those who died had been discharged from hospital during the previous vaccination season. Persons discharged with high-risk conditions during the vaccination season were at greater risk for hospitalization with influenza-associated respiratory conditions but were less likely to be vaccinated than were those at lower risk. Conclusions: Most persons who were hospitalized with influenza-associated respiratory conditions had contact with health care providers during the preceding influenza vaccination season. Among elderly patients, previous hospital care was common, especially among those who died. The disparity between influenza vaccination rates and risks for influenza-associated hospital discharge and death supports a strategy of hospital-based influenza vaccination.
Research on the Fetus
Authors: Leonie S. Watson
Journal: JAMA (1974)

To the Editor.—  They casually dismiss all objections to abortion as a matter of philosophic preference and imply that only in the context of lawless laissez-faire will science progress.  Abortion is not a victimless crime. It entails a lethal attack on the life of the defenseless unborn. Antiabortion legislation formalizes our most fundamental commitment, personal and professional, to the sanctity of human life. Reasonable and proper research neither requires nor justifies a legislative carte blanche.  Serious attention to establishment of ethical guidelines for fetal experimentation preserves the dignity of life, while permitting continuance of legitimate research. We must ensure that no less reverence is accorded the remains of the unborn child than that of the delivered. Immediate and forceful restrictions must be imposed on experimentation with the living abortus. Unassailed reports of grotesque manipulation of breathing, beating-heart products of conception stand as an indictment of the entire medical profession. The
[352] EPITHELIAL- MESENCHYMAL TRANSITION IN HUMAN HEPATOCELLULAR CARCINOMA CELLS UNDER HYPOXIA: A BETA-CATENIN AND SNAIL-MEDIATED EVENT FAVOURING MIGRATION AND/OR INVASIVENESS
Authors: S. Cannito, E. Novo, C. Cravanzola, E. Zamara, A. Compagnone, L. Valfre' di Bonzo, A. Bandino, S. Colombatto, M. Parola
Journal: Journal of Hepatology (2007)
Responses of cultured heart cells to procainamide and lignocaine
Authors: D. McCALL
Journal: Cardiovascular Research (1978)

The effects of procainamide and lignocaine, in concentrations from 10(-6) to 10(-2) mol.litre(-1), on the Na influx and contraction frequency of cultured heart cells were studied. Both drugs produced a prompt, dose-dependent reduction in Na influx which was significant (P less than 0.01) for all concentrations tested. Lignocaine affected only that portion of the Na influx which was also verapamil-sensitive, whereas procainamide suppressed in addition, the verapamil-insensitive influx. In addition both drugs produced a concomitant decrease in the spontaneous contraction frequency of the cells. A close linear correlation (r = 0.99) between verapamil-sensitive Na influx and contraction frequency, in the presence of both procainamide and lignocaine was found. From this, and previous studies indicating a dependency of contraction frequency on the inward verapamil-sensitive Na influx, it is suggested that the drugs modify the automaticity of this preparation by a primary influence on membrane Na exchange.
A Phase Ib dose escalation study of afatinib in combination with standard-dose cetuximab in patients with advanced solid tumours
Authors: J.-C. Soria, V. Boni, A. Gazzah, E. Holgado, C. Even, M. Ould-Kaci, S. Nazabadioko, W. Xue, E. Calvo
Journal: Annals of Oncology (2015)
The Combined Association of Psychological Distress and Socioeconomic Status With All-Cause Mortality
Authors: Antonio Ivan Lazzarino, Mark Hamer, Emmanuel Stamatakis, Andrew Steptoe
Journal: JAMA Internal Medicine (2012)

Background: Psychological distress and low socioeconomic status (SES) are recognized risk factors for mortality.The aim of this study was to test whether lower SES amplifies the effect of psychological distress on all-cause mortality.Methods: We selected 66 518 participants from the Health Survey for England who were 35 years or older, free of cancer and cardiovascular disease at baseline, and living in private households in England from 1994 to 2004.Selection used stratified random sampling, and participants were linked prospectively to mortality records from the Office of National Statistics (mean follow-up, 8.2 years).Psychological distress was measured using the 12-item General Health Questionnaire, and SES was indexed by occupational class. Results:The crude incidence rate of death was 14.49 (95% CI, 14.17-14.81)per 1000 person-years.After adjustment for age and sex, psychological distress and low SES category were associated with increased mortality rates.In a stratified analysis, the association of psychological distress with mortality differed with SES (likelihood ratio testadjusted P Ͻ.001), with the strongest associations being observed in the lowest SES categories. Conclusions:The detrimental effect of psychological distress on mortality is amplified by low SES category.People in higher SES categories have lower mortality rates even when they report high levels of psychological distress.
Epidermodysplasia verruciformis in the setting of graft-versus-host disease
Authors: Joy H. Kunishige, Sharon R. Hymes, Vandana Madkan, Angela J. Wyatt, David Uptmore, Alexander J.F. Lazar, Sergio Giralt, Peter Rady, Stephen Tyring
Journal: Journal of the American Academy of Dermatology (2007)
Priming and inducing effects of interleukin‐3 on histamine release from cord‐blood basophils
Authors: A. Miadonna, C. Salmaso, M. P. Di Marco, L Pugni, N. Milazzo, A. Tedeschi, A. Marini
Journal: Allergy (1997)

The effect of interleukin-3 (IL-3) on histamine release from cord and adult blood basophils were evaluated. Leukocyte suspensions, obtained from adult patients with respiratory allergy (n = 15), normal adult subjects (n = 15), and neonates with (n = 15) and without (n = 19) atopic disposition, were stimulated with anti-IgE, fMLP, and IL-3. IgE-mediated histamine release was significantly higher in adult patients, either allergic or normal, than in neonates with or without atopic disposition. A trend toward higher fMLP-induced histamine release was found in allergic adult subjects. IL-3 had a weak direct histamine-releasing activity in allergic adult subjects and in neonates, but not in normal adult donors. A significant enhancing effect of IL-3 on histamine release induced by anti-IgE was observed in neonates with and without atopic disposition and in normal adult subjects, but not in atopic adult patients. IL-3 exerted a priming effect also when basophils were stimulated with fMLP, without any significant difference between neonates and adult subjects. Passive sensitization with IgE-rich serum resulted in a significant increase in anti-IgE-induced, but not in IL-3-induced, histamine release from cord-blood basophils. In conclusion, IL-3 primes cord-blood as well as adult blood basophils for a consecutive anti-IgE- or fMLP-induced histamine release and its activity is not limited by the low density of membrane IgE in cord-blood basophils.