tbuckley/cabot-search huggingface dataset:
Periodic Physician Recredentialing
Authors: Roy F. Beckett
Journal: JAMA (1991)

To the Editor.—  I read with considerable interest the article by Gellhorn. 1   The concepts and data presented certainly stimulate thought and discussion. I would, however, like to point out certain inaccuracies relating to the Ontario experience. The Peer Assessment Program referred to in the article was envisaged, developed, and is operated not by the Ontario Medical Association but by the College of Physicians and Surgeons of Ontario. The medical profession, which numbers approximately 26 000 in Ontario, is licensed and self-governed by the college. The program has indeed been operating for a decade, but during that time, contrary to what is stated in the article, the practices of approximately 2600 physicians of all age groups have been assessed. This figure includes family physicians and specialists from 13 major disciplines.  An evaluation of the data obtained after the first 5 years of the program clearly revealed that a much higher
Meningococcal disease and healthcare workers
Authors: A. J Pollard, N. Begg
Journal: BMJ (1999)

Although Neisseria meningitidis is a relatively uncommon cause of overt infection (2580 notifications in 1998),1 the horrors of its clinical presentation have stimulated intense media interest, particularly after outbreaks. With the disappearance of many infectious competitors in the latter half of this century, meningococcal disease has become the leading infectious cause of death in childhood and is now the third most common cause of death in children outside infancy (after accidents and malignancy).2 The introduction in October 1999 of a serogroup C protein-polysaccharide conjugate vaccine for children and young adults has the potential to reduce significantly the incidence of disease.3 Nevertheless, most cases are caused by serogroup B meningococci, for which no vaccine is available, and the disease will remain prevalent in the United Kingdom. As a result of the dramatic presentation of cases and the high fatality rate the perceived risk of meningococcal disease is high among those who have had …
Porphyria cutanea tarda and hepatocellular carcinoma: Correlations
Authors: Kunio Okuda
Journal: Hepatology (1986)

In order to assess the incidence of hepatocellular carcinoma (HCC) in porphyria cutanea tarda (PCT), 83 patients (77 males, 6 females, mean age 57.4 years) were studied. Thirteen patients (15.7%) had HCC, all of whom were male and cirrhotics with a mean age of 58.5 years. HCC patients showed a statistically significant (P &lt; 0.0005) longer evolution time (23 years since onset of the cutaneous disease) than patients without HCC (9.4 years), while the age of onset was similar in both groups. Differences in alcohol intake and hepatitis B virus (HBV) markers were non-significant, although high prevalence (54%) of past HBV infection was found in both groups. In HCC development, attributable risks of 100% were found for cirrhosis (P &lt; 0.001), male sex (P = NS) and for age over 51 (P &lt; 0.025). Therefore, PCT harbours a high incidence of HCC; evolution time, cirrhosis and age over 51 appear to be the most important contributing factors.
Vasculitis with Alcofenac Therapy
Authors: R. A. Billings, H. C. Burry, F. S. Emslie, G. D. Kerr
Journal: BMJ (1974)

Three patients developed a vasculitis while taking alclofenac. Two recovered with corticosteroid therapy, and the third, who had continued to take the drug for a further week despite epistaxis, haemoptysis, haematuria, and cutaneous vasculitis, developed a more persistent vasculitis with histological evidence of progressive renal involvement.
Food-Borne Illnesses
Authors: Sharon Parmet
Journal: JAMA (2003)

Food-Borne IllnessesF ood-borne illnesses (sometimes called food poisoning) are caused by eating foods contaminated with pathogens (disease-causing agents) such as viruses, parasites, bacteria, or fungi.Raw, unwashed, or undercooked foods are at greatest risk of being contaminated.However, most food-borne illnesses can be prevented if food is handled properly.Typical symptoms of food-borne illnesses include nausea, vomiting, diarrhea, abdominal cramps, and sometimes fever.Infants, the elderly, and people with diabetes, cancer, or AIDS are at an increased risk because their immune systems may not be functioning properly.A severe complication of some types of food-borne illness is hemolytic uremic syndrome, a combination of anemia (low red blood cell count), profuse bleeding, and kidney failure.The September 10, 2003, issue of JAMA includes 2 articles about hemolytic uremic syndrome in persons aged 1 month to 18 years.
England to have more walk-in clinics
Authors: L. Beecham
Journal: BMJ (1999)

Seventeen new walk-in health clinics are to be set up in England, bringing the total to 36, the UK health secretary, Frank Dobson, told the Labour party conference last week.

The centres will offer free consultations, minor treatment, and health information from7 00 am to 10 00 pm, including weekends. The clinics, along with the 24 hour NHS Direct telephone advice service, which covers 40% of England, are part of the government's 10 year programme to modernise the …
Prevention of Malaria-Reply
Authors: Donald Catino
Journal: JAMA (1984)

<h3>In Reply.—</h3> Onori and Hempel's response to our letter gives some international perspective to the problem of malaria prophylaxis in travelers. It seems that the Europeans are doing a better job than we are in making information on malaria prophylaxis available to travelers. However, we know of no study that proves that European travelers are any better informed or protected. We agree with Onori and Hempel that there is a plethora of information concerning malaria prophylaxis. It seems that the problem is getting that information to the traveler. Although some airlines do an excellent job informing their travelers, most American airlines do not. BOAC could serve as a model for other airlines. They make in-flight announcements concerning the risk of malaria, provide pamphlets to the travelers, and also provide prophylactic medication to those needing it.<sup>1</sup>Onori and Hempel mention that<i>TIM</i>is used by many airlines. However, TWA is
Response of Infants to a Third Dose of Poliomyelitis Vaccine Given 10 to 12 Months after Primary Immunization
Authors: F. T. Perkins, R. Yetts, W. Gaisford
Journal: BMJ (1959)

IMMUNIZATION AGAINST POLIOMYELITIS BAJn in December, 1956, with the most highly attenuated currently available strains of each of the three types, have thus far produced no untoward reactions in vaccinees or their contacts.Spread of the vaccine viruses to others is an accepted fact in the immunization with live poliovirus vaccines, and this problem is not being "side-stepped " but is rather being carefully studied in various trials.The trials on some hundreds of thousands of children-some already completed, others now in progress, and still others to be initiated in 1959-carried out in accord with the stipulations of the Expert Committee on Poliomyelitis of the World Health Organization should provide us in the near future with the information necessary for a decision regarding the place of orally administered live poliovirus vaccines in the prevention and eradication of poliomyelitis.
Turner's Infantile Phenotype
Authors: R. R. Gordon, E. M. O'Neill
Journal: BMJ (1969)

Turner's infantile phenotype is a term used to describe infants with stigmata suggestive of Turner's syndrome. These include brawny oedema of the feet, loose neck folds, and a characteristic facies. Ten cases are described in this report. Four of these had a similar facial appearance and three had serous effusions. Two of the latter died and at necropsy no cardiac, vascular, or renal cause for the effusions was found, but the gonads in each were macroscopically reduced in size and microscopically were grossly abnormal.
Primary Pulmonary Hypertension in Patients with Classic Hemophilia
Authors: GEORGE H. GOLDSMITH
Journal: Annals of Internal Medicine (1988)

Five patients with classic hemophilia were found to have primary pulmonary hypertension, a disorder not previously recognized in this population. All patients had had their coagulation disorder treated for 10 years or more with self-administered lyophilized concentrates of factor VIII, and all had antibodies to human immunodeficiency virus (HIV). Primary pulmonary hypertension was confirmed by histologic means at autopsy in one patient and by lung biopsy findings in another. In the other three patients, the findings are in agreement with this diagnosis. No patient had underlying cardiac or pulmonary disease, or clinical or pathologic evidence of collagen-vascular disease, vasculitis, parasitic disorders, hemoglobinopathy, or exposure to anorexigenic agents. Whether the primary pulmonary hypertension was related to treatment with lyophilized factor VIII, or to the presence of antibodies to HIV, or both, is unknown.
Predictors and prognostic values of CK-MB cardiac enzyme elevation after coronary intervention with radiation treatment in in-stent restenosis
Authors: Thosaphol Limpijankit, G. Dangas, R. Mehran, A.A. Lansky, G.W. Stone, N. Kipshidze, M. Astatkie, M. Hawkey, D. Ashby, M. Mohamed, I. Moussa, M.B. Collins, J.W. Moses, M.B. Leon
Journal: Journal of the American College of Cardiology (2002)
Limitations of Applying Summary Results of Clinical Trials to Individual Patients
Authors: David M. Kent, Rodney A. Hayward
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Histology of the persistent ductus arteriosus in cases of congenital rubella.
Authors: A C Gittenberger-de Groot, A J Moulaert, J F Hitchcock
Journal: Circulation (1980)

Histologic study of the persistent ductus arteriosus in case of a congenital rubella syndrome revealed that this persistency is probably due to an arrest in the development of the ductus. Histologically, it resembles a very immature ductus and not the most common type of persistent ductus arteriosus. The earlier finding, that in the human ductus arteriosus, the presence of an extensive subendothelial elastic lamina is incompatible with anatomic sealing, still holds.
Early Use of X-ray Machines and Electrocardiographs at the Pennsylvania Hospital
Authors: John H. Dirckx
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Dr Howell's<sup>1</sup>article on the early use of the x-ray machine and electrocardiograph at the Pennsylvania Hospital provides valuable data on the dawn of technology in American institutional medicine. Although Dr Howell chose to emphasize nontechnical aspects of the subject, a few historical notes on electrocardiography may add perspective to his remarks. The electrocardiograph as manufactured in 1921 was an enormous machine weighing at least 350 kg and occupying 4 m<sup>2</sup>or more of floor space. Only standard limb leads (I, II, and III) were recorded. The usual practice was for the subject, seated, to immerse both arms and the left leg in jars of saline, which served as electrodes. These facts probably explain why, at the Pennsylvania Hospital, a separate room was set aside to house the first electrocardiograph. Then, as now, the essential element in the electrocardiograph was a galvanometer, so arranged as
LDH-Binding Immunoglobulins
Authors: SUSUMU IMOTO
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 July 1975LDH-Binding ImmunoglobulinsSUSUMU IMOTO, M.D.SUSUMU IMOTO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-1-123_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The paper by Dr. Thomas and associates in the October 1974 issue (Ann Intern Med 81:434-439, 1974) prompts me to report the case of a 64-year-old man with oxyphenisatin-induced lupoid hepatitis.Total lactate dehydrogenase (LDH) activity in serum was 653 Wróblewski units per litre. The serum LDH isoenzyme pattern showed only a single component that was in the LDH-4 position. A hemolysate of washed erythrocyte cells from this patient showed a normal LDH isoenzyme pattern. On gel filtration through a Sephadex G-200 column, all of the LDH activities of this patient's serum were eluted between 7S and...References1. IMOTO S, UCHITA K, and TAKATSUKI K: Studies on properties of LDH-binding immunoglobulin. Jap J Gastroenterol 71:1249-1255, 1974 MedlineGoogle Scholar2. SAGA M, KANO S, and KANNO T: LDH isoenzyme anomaly patterns in 40 cases. Phys-Chem Biol 18:61-63, 1973 Google Scholar3. BIEWENGA J and FELTKAMP T: LDH-IgA immunoglobulin complexes in human serum. Clin Chim Acta 58:239-249, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SUSUMU IMOTO, M.D.Affiliations: Department of Internal Medicine Shinko Hospital Wakinohama, Fukiaiku, Kobe 651 Japan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1975Volume 83, Issue 1Page: 123-123KeywordsCellsHepatitis ALactate dehydrogenase ePublished: 1 December 2008 Issue Published: 1 July 1975 PDF downloadLoading ...
Myopathy in McArdle's Syndrome
Authors: Alfred E. Slonim, Pamela J. Goans
Journal: New England Journal of Medicine (1985)

IN normal muscle, the principal sources of energy during exercise are glucose and fatty acids. The proportion of energy derived from each of these substrates depends on the intensity and duration of exercise.1 Amino acids are known to serve two important functions of muscle metabolism: they furnish a substrate for muscle protein synthesis and provide amino groups for the production of the gluconeogenetic amino acids alanine and glutamine.2 Evidence is now available that certain amino acids, in particular the branched-chain amino acids, may also serve as a direct source of muscle energy.2 In McArdle's syndrome (myophosphorylase deficiency), muscle glycogenolysis is . . .
FEAR AS AN ELEMENT OF NERVOUS DISEASES AND ITS TREATMENT.
Authors: JOHN PUNTON
Journal: JAMA (1901)

Fear as an element of disease has become so very prevalent and common that its study deserves more than a passing notice. While its universal prevalence is recognized to some degree at least in nearly all forms of disease, yet it is in the departments of neurology and psychiatry that we find its most serious effects and disastrous consequences. Fear is defined by Gould as an emotion of dread, an apprehension the feeling of which in its intense manifestations is called terror or fright. Generally speaking, fear is the expression of a desire on the part of the individual to escape or ward off whatever may seem to threaten evil or work harm to his well-being. It therefore conforms to the instinctive power immanent in man and animals of self-preservation. As such it exists normally in every individual in varying degrees of intensity and subject more or less to the
ENEMATA OF WHITES OF EGGS. MEMORANDUM.
Authors: JOHN ASHBURTON CUTTER
Journal: JAMA (1895)

Albumen of eggs is valuable to feed patients when other forms of nourishment can not be taken or to reinforce other nourishment. I have known patients to take the whites of eighteen eggs in one day with evident advantage, in some cases the result appearing almost life-saving. Exhibition by the mouth is made in three ways: 1, raw; 2, raw with milk; 3, dropped in boiling water and slightly cooked. Enemata of uncooked whites I have lately used with decided benefit. Administration by a Davidson hard rubber syringe No. 494, one ounce. Eggs vary in size and weight and should be sold by weight; the albumen of an egg varies in bulk from one-half to one ounce as eggs run. Drugs can be administered with the raw albumen; sometimes a little laudanum is needed, but rarely, to quiet bowel. Patients state that an enema relieves the faint gone feeling in
Ban against industry ties introduces bias and obscures whole view
Authors: L. McCay
Journal: BMJ (2011)

By singling out industry ties,1 the BMJ proposes to systematically discriminate against a particular group of people without evidence based justification. This is concerning not only from an ethical perspective but also because it ignores the wider issue of conflicts of interest, introduces bias, deters productive collaborations, marginalises industry doctors rather than incentivising their academic and ethical rigour, and …
Minocycline-induced Pneumonia
Authors: Peter Sigmann
Journal: Annals of Internal Medicine (1993)

Letters1 May 1993Minocycline-induced PneumoniaPeter Sigmann, MDPeter Sigmann, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-9-199305010-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Guillon and colleagues [1] evaluated the mechanism of hypersensitivity pneumonitis after exposure and re-exposure to minocycline in a patient with chronic lung disease. We saw a similar phenomenon in 1986 in a 17-year-old woman without chronic lung disease. She experienced progressively severe pulmonary and extrapulmonary reactions to exposure and inadvertent re-exposures to minocycline.The patient had taken minocycline, 100 mg/d, for 18 months to control acne vulgaris. In childhood, she had been treated for myasthenia gravis, and the disease had been in remission for 5 years. A nonproductive cough began 4 weeks before evaluation, and a sore ...References1. Guillon JM, Joly P, Autran B, Denis M, Akoun G, Debre P, et al. Minocycline-induced cell-mediated hypersensitivity pneumonitis. Ann Intern Med. 1992; 117:476-81. Google Scholar2. Kuroki H, Usami I, Hanaki H. A case of minocycline-induced pneumonitis. Nippon Kyobu Shikkan Gakkai Zasshi. 1986; 24:553-7. Google Scholar3. Ho D, Tashkin DP, Bein ME, Sharma O. Pulmonary infiltrates with eosinophilia associated with tetracycline. Chest. 1979; 76:33-4. Google Scholar Author, Article, and Disclosure InformationAuthors: Peter Sigmann, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMinocycline-Induced Pericardial EffusionDrug-induced pulmonary disease 1 May 1993Volume 118, Issue 9Page: 749-750KeywordsAntibodiesHypersensitivityLungsPharyngitisPneumoniaPneumonitisTemperatureTetracyclinesToxicityUpper respiratory tract infections ePublished: 15 August 2000 Issue Published: 1 May 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Rituximab combined with chemotherapy and interferon in follicular lymphoma patients: results of the GELA-GOELAMS FL2000 study
Authors: Gilles Salles, Nicolas Mounier, Sophie de Guibert, Franck Morschhauser, Chantal Doyen, Jean-François Rossi, Corinne Haioun, Pauline Brice, Béatrice Mahé, Reda Bouabdallah, Bruno Audhuy, Christophe Ferme, Caroline Dartigeas, Pierre Feugier, Catherine Sebban, Luc Xerri, Charles Foussard
Journal: Blood (2008)
The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation
Authors: Jingling Jin, Polina Iakova, Yanjun Jiang, Estela E. Medrano, Nikolai A. Timchenko
Journal: Hepatology (2011)

Age declines liver functions, leading to the development of age-associated diseases. A member of the sirtuins family, SIRT1, is involved in the control of glucose homeostasis and fat metabolism. Because aging livers have alterations in glucose and fat metabolism, we examined a possible role of SIRT1 in these alterations. We found that aged livers have a reduced expression of SIRT1 and have lost proper control of the regulation of SIRT1 after partial hepatectomy (PH). Down-regulation of SIRT1 in the liver of old mice is mediated by CCAAT/Enhancer Binding Protein/histone deacetylase 1 (C/EBPβ-HDAC1) complexes, which bind to and repress the SIRT1 promoter. In the livers of young mice, SIRT1 is activated after PH and supports high levels of glucose and triglycerides during liver regeneration. In old mice, however, C/EBPβ-HDAC1-mediated repression of the SIRT1 promoter blocks activation of SIRT1, leading to low levels of glucose and triglycerides during liver regeneration. Down-regulation of SIRT1 in the livers of young mice resulted in alterations similar to those observed in the livers of old mice, whereas the normalization of SIRT1 in the livers of old mice corrects the levels of glucose and triglycerides after PH. The normalization of SIRT1 in old mice also improves liver regeneration via the elimination of the C/EBPα-Brm complex. These studies showed a critical role of the reduction of SIRT1 in age-associated liver dysfunctions and provide a potential tool for the correction of liver functions in old patients after surgical resections.
Drug–Gene Modeling in Pediatric T-Cell Acute Lymphoblastic Leukemia Highlights Importance of 6-Mercaptopurine for Outcome
Authors: Alex H. Beesley, Martin J. Firth, Denise Anderson, Amy L. Samuels, Jette Ford, Ursula R. Kees
Journal: Cancer Research (2013)

Patients relapsing with T-cell acute lymphoblastic leukemia (T-ALL) face a dismal outcome. The aim of this study was to identify new markers of drug resistance and clinical response in T-ALL. We measured gene expression and drug sensitivity in 15 pediatric T-ALL cell lines to find signatures predictive of resistance to 10 agents used in therapy. These were used to generate a model for outcome prediction in patient cohorts using microarray data from diagnosis specimens. In three independent T-ALL cohorts, the 10-drug model was able to accurately identify patient outcome, indicating that the in vitro-derived drug-gene profiles were clinically relevant. Importantly, predictions of outcome within each cohort were linked to distinct drugs, suggesting that different mechanisms contribute to relapse. Sulfite oxidase (SUOX) expression and the drug-transporter ABCC1 (MRP1) were linked to thiopurine sensitivity, suggesting novel pathways for targeting resistance. This study advances our understanding of drug resistance in T-ALL and provides new markers for patient stratification. The results suggest potential benefit from the earlier use of 6-mercaptopurine in T-ALL therapy or the development of adjuvants that may sensitize blasts to this drug. The methodology developed in this study could be applied to other cancers to achieve patient stratification at the time of diagnosis.