tbuckley/cabot-search huggingface dataset:
Blistering skin disease in a man after injections of human placental extracts.
Authors: J. H. Saurat, L. Didierjean, Y. Merot, D. Salomon
Journal: BMJ (1988)

Une observation: un malade de 79 ans se fait faire des injections d'extraits placentaires «pour stimulation biologique» et presente des eruptions vesiculeuses et prurigineuse, ressemblant a une pemphigoide bulleuse. Le serum ne reagit pas avec l'antigene de pemphigoide, mais reagit avec des antigenes presents dans les extraits placentaires et dans la membrane basale epidermique
Doctors in distress
Authors: B. Bury
Journal: BMJ (1996)

What is wrong with us all? As a junior doctor wins damages after taking his employing authority to court—accusing them of inhuman treatment—I am prompted to retrieve from my box of cuttings a news item from the BMJ encouragingly headed “Doctors are more miserable than ever” (BMJ 1994;309:1529). This is just one in an apparently endless stream of pieces in which colleagues tell an uncomprehending world about their insupportably dreary existence. Of course, some of the complaints are justified. Junior doctors have been working longer hours than is sensible and they do spend a lot of their time carrying out tasks which could easily be delegated to others. But although something is being done about that, still the whingeing goes on. And it is not just the juniors. Every week we read the result of yet another survey claiming to illustrate the unprecedented depths now being plumbed by consultants' morale as they struggle to come to terms with the “reformed” NHS.

But let us start with the juniors. The BMJ report was fairly typical in the reasons it gave for their dissatisfaction. The young doctors “resented being used as workhorses and dogsbodies”; they want “to be treated as professionals, but they feel that they are like ants at the bottom of the heap.” I have to be careful here. I have …
Heparin-like Activity, Atopic Eczema, and Contact Dermatitis
Authors: C. BOINOT
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 August 1986Heparin-like Activity, Atopic Eczema, and Contact DermatitisC. BOINOT, J: MARTIN, M. LARREGUEC. BOINOTSearch for more papers by this author, J: MARTINSearch for more papers by this author, M. LARREGUESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-2-302_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Circulating heparin-like anticoagulants have been reported in patients with systemic mastocytosis (1), in one patient with acute monoblastic leukemia (2), in patients with plasma cell leukemia (3), and in one with esophageal carcinoma (4). We report the presence of similar circulating factors found in a patient with eczema, an association that has not yet been described.A 17-year-old woman with a family history of atopic disease was admitted in our department for treatment of eczematous lesions at the elbow and wrists and under the ears. Recently, she had developed evidence of erythematous and vesicular dermatitis after local...References1. CAMPBELLHECTORGOSSAIN EDV. Heparin activity in systemic mastocytosis. Ann Intern Med. 1979;90:940-1. LinkGoogle Scholar2. BUSSELSTEINHERZMILLERHILGARTNER JPDM. A heparin-like anticoagulant in an 8-month-old boy with acute monoblastic leukemia. Am J Hematol 1984;16:83-90. CrossrefMedlineGoogle Scholar3. PALMERRICKRICKZELLERGRALNICK RMPJH. Circulating heparin sulfate anticoagulant in a patient with a fatal bleeding disorder. N Engl J Med. 1984;310:1696-9. CrossrefMedlineGoogle Scholar4. WATTSCHISHOLMHICKTONSMITH EMMA. Circulating heparin-like anticoagulants. N Engl J Med. 1984;311:1055. CrossrefMedlineGoogle Scholar5. TEIENLIEABILDGAARD AMU. Assay of heparin in plasma using a chromogenic substrate for activated factor X. Thromb Res. 1976;8:413-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Centre Hospitalier Universitaire 86021 Poitiers France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1986Volume 105, Issue 2Page: 302-302KeywordsAnticoagulantsContact dermatitisEczemaElbowLesionsPlasma cellsSystemic mastocytosis Issue Published: 1 August 1986 PDF downloadLoading ...
Multiple Brown Tumors With Tc-99m MDP Superscan Appearance and Negative Tc-99m MIBI Uptake
Authors: Adonios Zanglis, Demetrios Andreopoulos, Athanassios Zissimopoulos, Nikolaos Baziotis
Journal: Clinical Nuclear Medicine (2006)

A 20-year-old man presented with a spontaneous left humerus fracture after minimal loading. X-rays and a CT scan revealed multiple lytic lesions throughout the skeleton (humeri, ribs, spine, pelvic bones, femorals). Blood chemistries showed severe hypercalcemia of 15.7 mg/dL and hypophosphatemia, whereas the biopsy of a lytic lesion (right humerus) showed only a few macrophages and multinuclear giant cells. Tc-99m MDP and Tc-99m MIBI scans were performed. Neck surgery verified the presence of a parathyroid adenoma. The multiple lytic lesions that were seen are brown tumors (osteoclastomas) without focal Tc-99m MDP or Tc-99m MIBI uptake.
Abstract 3102: Oncogenic PWWP-domain protein WHSC1L1 links the homeobox transcription factor IRX3 in breast cancer
Authors: Gang Liu, Zeng-Quan YANG, Stephen P. Ethier
Journal: Cancer Research (2010)

Abstract Amplification of the 8p11-12 region has been found in about 10-15% of human breast cancer and may be associated with poor prognosis. Earlier, we used genomic analysis of copy number and gene expression to perform a detailed analysis of the 8p11-12 amplicon for identifying candidate oncogenes in breast cancer. We identified Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) as a candidate oncogene based on statistical analysis of copy number increase and over expression. The WHSC1L1 gene encodes a PWWP domain protein that regulates histone methylation marks, and regulates the transcription profile and the differentiated function of cells. To address the question of whether WHSC1L1 possesses transforming properties, we established lentiviral expression constructs containing the WHSC1L1 as well as other 20 candidate genes of 8p11-12 region. MCF10A cells were infected with these lentiviral vectors and assayed for alterations in growth rates, growth factor-independent proliferation, anchorage-independent growth and for three-dimensional morphogenesis assays in Matrigel culture. From these experiments, we found that the WHSC1L1 is the most potently transforming oncogene we tested from the 8p11-12 region. Furthermore, knockdown of this gene in WHSC1L1 amplified breast cancer cells resulted in profound loss of growth and survival potential in these cells. To identify genes that may be regulated in their expression by the WHSC1L1 when it is amplified and over expressed, we performed expression profiling of MCF10A cells, MCF-10AWHSC1L1 cells, and WHSC1L1 amplified SUM-44 breast cancer cells. Analysis of genes altered by over expression of WHSC1L1 in MCF10A-WHSC1L1 cells and in SUM-44 cells resulted in the identification of 184 WHSC1L1 candidate target genes. Among them was the iroquois homeobox 3 gene (IRX3), a member of the Iroquois homeobox transcription factor family. The regulation of IRX3 gene expression by WHSC1L1 was validated in SUM44 breast cancer cells using WHSC1L1 knock down. IRX3 mRNA was dramatically down-regulated in SUM-44 cells after WHSC1L1 shRNA infection. Intriguingly, in our array CGH study we found that SUM-44 cells also have a gene amplification of IRX3. Thus, our finding indicates that WHSC1L1 is the major driving oncogene in the 8p11-12 amplicon, and provides the first evidence that WHSC1L1 and IRX3 are genetically linked in subset of breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3102.
Apical Left Ventriculotomy in Subaortic Stenosis due to a Fibromuscular Hypertrophy
Authors: ORMAND C. JULIAN, WILLIAM S. DYE, HUSHANG JAVID, JAMES A. HUNTER, JOSEPH J. MUENSTER, HASSAN NAJAFI
Journal: Circulation (1965)

A total of five patients were operated upon for subaortic stenosis due to fibromuscular hypertrophy, using a generous left ventriculotomy centered on the apex. There were no deaths or serious complications, and all patients showed a completely satisfactory functional result in the postoperative periods of 19, 17, 11, 8, and 7 months. Three patients recatheterized 16, 11, and 7 months after surgery were found to have a virtual abolition of the gradient. Pressure measurements made at the completion of surgery in all patients, indicated satisfactory removal of the obstruction. The excellent exposure afforded by this ventriculotomy and the absence of complications arising from its use, recommend it for continued trial. It must, however, stand comparison with other techniques on the basis of the durability of the relief of obstruction.
Surgical Applications of Laser
Authors: James T. Helsper
Journal: JAMA (1966)

This book is a collection of most of the studies of the biological applications of laser energy, with particular emphasis on the author's work with malignant tumors. After reviewing the important events in cancer research during the previous 25 years, the author describes the theory of laser energy and the mechanism of its production. Various types of lasers are shown in excellent photographs. The parameters and experimental results of laser in the most common tumor-test system, that of Syrian hamster cheek pouches, are reviewed next. Convincing photographs and photomicrographs support the theorem that laser energy does have a lethal effect on cancers growing in the cheek pouches. All of the tumor systems which the author tested are carefully reported. The use of laser energy in human cancer treatment is still strictly a research tool. The author reviews several hypotheses explaining the varying effects from laser energy in human tumors, and
The Comparative Safety of Suprapublic Lithotomy, of Lateral Lithotomy, and of Litholapaxy in Young Males
Authors: G. Barling
Journal: BMJ (1894)

and overliangihi, as in rlheumatoid disease; the articular cartilage was tll!), frayed anid in places, especially on the inner condyle, grooved antero-posteriorly, but the articular plate of boiie wvas nowhlere exposed; tlhus eburnation, so cha- racteristic of rlheumatoid disease, was absent.Furthter, the synovial memibrane that covers the outer sides of the con- dyles for about hialf an inclh from the articular margin was covered, Just as that immediately above the patella, by in- numnerable slenider and delicate polypi.The chiief clhanges iii the articulai end of the femur are well shown in Fig. 3. Big.,.-Lowcr end of femur, showing lipping of articular margins and grooving of articular cartilage.Natural size.
Molecular Determinants of Glucocorticoid Receptor Function and Tissue Sensitivity to Glucocorticoids
Authors: CHRISTOPH M. BAMBERGER, HEINRICH M. SCHULTE, GEORGE P. CHROUSOS
Journal: Endocrine Reviews (1996)

Glucocorticoids play an essential role in maintaining basal and stress-related homeostasis, and lack of glucocorticoid action is incompatible with life in primates. Most known effects of glucocorticoids are mediated by the intracellular GR. The magnitude of a cell's response to glucocorticoids depends both on the hormone level it is exposed to and on its glucocorticoid sensitivity, i.e. the efficiency of GR-mediated signal transduction. In this review, we have summarized the multiple endogenous and exogenous factors that have been shown to be involved in this signaling cascade and, thus, to alter glucocorticoid sensitivity.
Hydrology and Climatology
Authors: L. C. Hill
Journal: BMJ (1933)

<h3>Objective</h3> Interventions to promote walking have focused on individual or group-based approaches, often via the randomised controlled trial design. Walking can also be promoted using population health approaches. We systematically reviewed the effectiveness of population approaches to promote walking among individuals and populations. <h3>Design</h3> A systematic review. <h3>Data sources</h3> 10 electronic databases searched from January 1990 to March 2017. <h3>Eligibility criteria</h3> Eligibility criteria include pre-experimental and postexperimental studies of the effects of population interventions to change walking, and the effects must have been compared with a ‘no intervention’, or comparison group/area/population, or variation in exposure; duration of ≥12 months of follow up; participants in free-living populations; and English-language articles. <h3>Results</h3> 12 studies were identified from mostly urban high-income countries (one focusing on using tax, incentivising the loss of parking spaces; and one using policy only, permitting off-leash dogs in city parks). Five studies used mass media with either environment (n=2) or community (n=3) approaches. Four studies used environmental changes that were combined with policies. One study had scaled up school-based approaches to promote safe routes to schools. We found mass media, community initiatives and environmental change approaches increased walking (range from 9 to 75 min/week).
TYPE-SPECIFIC POLYSACCHARIDE ANTIGENS OF GROUP B STREPTOCOCCI
Authors: Earl H. Freimer
Journal: The Journal of Experimental Medicine (1967)

The type-specific antigen of Group B Type II streptococci has been prepared free of other known cell components. This antigen is a capsular polysaccharide containing D-galactose, D-glucose, N-acetyl-D-glucosamine, and a labile component which has not been chemically characterized. Extraction of Type II streptococci with cold TCA yielded this antigen which contained two serological determinants. A partial antigen with only one of the determinants was obtained by extraction with dilute HCl at 100 degrees C. By means of the quantitative precipitin inhibition technique, a (beta-D-galactopyranoside has been established as the determinant of the HCl-extracted polysaccharide. The second determinant, present solely in the TCA antigen, has not been identified.
Cardiac impairment or heart failure?: Changing the name has knock-on effects
Authors: Catie Gilbert
Journal: BMJ (2005)

The release of the government's latest report on health inequalities on 11 August was curious. 1 2 Reminiscent of the covert release of the Black report on August bank holiday in 1980, the report appeared when the minister for public health was on holiday and her deputy unavailable. Personal trainersIn July 2003 the government stated that there would be an annual report from the Department of Health on health inequality indicators related to the health inequality targets.Nothing appeared for more than two years, although the data that were eventually released had been available for some time, 3 and when they did appear it was, conveniently, after the election.Even stranger, the press release for the latest report deflected attention from the key finding of widening inequalities in life expectancy and infant mortality by headlining the 12 "early adopter sites" with their "health trainers." 4 The minister said, "Many people have difficulty in changing to a healthier way of life . . .Health trainers are one of the many initiatives in the white paper which will help narrow this gap by supporting people to make healthier choices in their daily lives." 4 To Labour traditionalists, opposed to victim blaming approaches to health promotion, this may have triggered memories of Conservative minister Edwina Currie admonishing the poor to buy cheap but healthy food.To New Labour, however, it may be grist to the mill.
Uremic Pleuritis — A Clinicopathological Entity
Authors: Bernard D. Nidus, Robert Matalon, Dan Cantacuzino, Robert P. Eisinger
Journal: New England Journal of Medicine (1969)

FIBRINOUS pericarditis is a well known feature of the uremic state. However, fibrinous pleuritis with pleural pain and friction rub in uremia has received little recognition.During the past 18 months, 20 clearly audible episodes of pleural rub were observed in 11 azotemic subjects. These patients, who had no evidence of pneumonia, pulmonary embolization or systemic disease as causes of the pleuritis, ranged in age from 23 to 76 years, and 10 were male (presumably reflecting the sex distribution in a Veterans Administration hospital). Seven patients had chronic proliferative glomerulonephritis, one membranous glomerulonephritis, one arteriolonephrosclerosis, one vasculitis with acute renal . . .
Interaction promotes cognition: The rise of childish minds
Authors: Stephen J. Cowley
Journal: Behavioral and Brain Sciences (2006)

Life history shaped language as, cascading in time, social strategies became more verbal. Although the insight is important, Locke &amp; Bogin (L&amp;B) also advocate a code model of language. Rejecting this input-output view, I emphasize the interpersonal dynamics of dialogue. From this perspective, childish minds as well as language could be derived from the selective advantages of a total interactional history.
Toxicity of styrene vapor in hepatocyte monolayers at low oxygen tensions.
Authors: A K Costa, J R Trudell
Journal: Environmental Health Perspectives (1990)

Hepatocyte monolayer cultures were exposed to 6000 ppm styrene vapor at 20%, 2%, or 1% O2 and assayed for signs of cell damage immediately following the 2-hr exposure and then 24 hr later. Oxygen concentrations were used that were previously shown to maximize lipid peroxidation and to predispose hepatocyte monolayers to chemical injury. The use of two time points allowed assessment of acute injury as well as injury that requires several hours to manifest itself. The uptake of styrene into the buffer in the culture dishes was measured by gas chromatography and was found to be 0.49, 0.68, and 0.74 mM at 15, 60, and 120 min, respectively. However, as measured by release of aspartate aminotransferase and inclusion of trypan blue, no toxicity was evident at either time point, irrespective of the oxygen concentration. This study shows that despite the weakening of hepatocyte defense mechanisms by hypoxia, styrene is not acutely toxic to these cells. Furthermore, if any damage to DNA, RNA, or the capability for protein synthesis occurs during exposure to styrene, it is insufficient to cause lysis within 24 hr.
Buruli Ulcer (M. ulcerans Infection): New Insights, New Hope for Disease Control
Authors: Paul D. R Johnson, Timothy Stinear, Pamela L. C Small, Gerd Pluschke, Richard W Merritt, Francoise Portaels, Kris Huygen, John A Hayman, Kingsley Asiedu
Journal: PLoS Medicine (2005)

The classic lesion is a necrotic skin ulcer with deeply undermined edges (Figure 2).Any part of the body can be
Social Environment and Regimen Adherence Among Type II Diabetic Patients
Authors: Russell E Glasgow, Deborah J Toobert
Journal: Diabetes Care (1988)

We investigated the reliability and predictive validity of several measures of the social environment using a sample of 127 adults with type II (non-insulindependent) diabetes. Of particular interest was a revised scale of family support for performing diabetes self-care behaviors. Across four different aspects of the diabetes regimen, it was consistently found that regimen-specific measures of family support differentiated subjects who were low, medium, or high on adherence better than global family-support scores. Social-environment measures were generally successful in predicting a subject's level of regimen adherence after accounting for variance attributable to demographic factors. The family-support measures were the strongest and most consistent predictors of adherence, but measures of stress and medical-care satisfaction and the interaction between stress and the other social-environment measures also often improved the prediction of a subject's adherence status. These results support the usefulness of measures of the social environment specific to diabetes, and research to investigate other aspects of the social context of regimen adherence is recommended.
Viruses and Atopic Sensitization in the First Years of Life
Authors: FERNANDO D. MARTINEZ
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Reports indicating that in most cases of asthma the first symptoms of bronchial obstruction occur during the first years of life (1) have focused a great deal of attention on the environmental factors that may predispose to or protect against the development of the disease in early life. Because the great majority of wheezing lower respiratory illnesses (LRIs) in infancy and early childhood are associated with microbiological evidence of an acute viral infection (2), it is not surprising that there has been renewed interest in the role of viruses in the inception of asthma. It is now well established, on the other hand, that most cases of childhood asthma in school-age children are associated with evidence of sensitization to local aeroallergens (3). It is still unclear, however, whether sensitization to specific antigens is causally related to the development of asthma. In this article, the role of viral respiratory infections and of sensitization to aeroallergens as predisposing factors for asthma are assessed, with special reference to events occurring during the first years of life.
Factors associated with asthma in Albania
Authors: A. V. Priftanji, E. Qirko, M. L. Burr, J. C. M. Layzell, K. L. Williams
Journal: Allergy (2002)

Background: This study was undertaken to see whether asthma in Albania (where it is particularly uncommon) is associated with certain ‘western’ characteristics, and with dietary and lifestyle factors that affect its occurrence elsewhere. Methods: A screening survey was conducted among 2653 persons aged 20–44 years. A more detailed enquiry was conducted among a random subsample plus all others whose response indicated possible asthma. Three groups were compared: 495 probable nonasthmatics (‘nonsymptomatics’); 106 with asthma‐like symptoms and positive skin tests (‘possible allergic asthmatics’); and 116 with similar symptoms and negative skin tests (‘other symptomatics’). Results: The possible allergic asthmatics were less likely than the nonsymptomatics to have attended school or nursery under the age of 5 years or to have shared a bedroom with an older child before that age. Continued education after the age of 18 years also appeared to be protective. Allowing for other factors, a strong negative relation was found with fruit and vegetable consumption, and weak positive relations with prepackaged food and fizzy drinks. Symptoms in skin prick test‐negative subjects were associated with personal and parental smoking habit. Conclusions: This survey provides limited evidence linking asthma with aspects of western lifestyle. It supports the hypothesis that opportunities for infection during early childhood and the consumption of fruit and vegetables protect against asthma.
Renal and pulmonary effects of angiotensin converting enzyme inhibition in chronic hypoxic lung disease.
Authors: R M Oliver, A J Peacock, J S Fleming, D G Waller
Journal: Thorax (1989)

The effects of 28 days9 treatment with captopril or with placebo on renal and pulmonary function were evaluated in nine patients with stable pulmonary heart disease. Captopril (25 mg twice daily) caused a 17% rise in effective renal plasma flow but no change in glomerular filtration rate, resulting in a fall in filtration fraction likely to favour natriuresis. Captopril did not alter FEV1, lung volumes, or arterial oxygen or carbon dioxide tension.
Abstract 17224: Increased Rate of Arterial Stiffening in Obese Adolescents as Compared to Lean in a Five Year Follow-Up Study
Authors: Frida Dangardt, Yun Chen, Krister Berggren, Alexandra Brinkaker, Peter Friberg
Journal: Circulation (2010)

Objective: We determined prospectively the effects of childhood obesity on arterial stiffening and vascular wall changes. Background: Childhood obesity confers an increased risk of vascular changes...