AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATT
Authors: WILLIAM G. LENNOX
Journal: Annals of Internal Medicine (1937)

Article1 October 1937AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATTTHE FLOW AND CONCENTRATION OF BLOOD AS INFLUENCED BY ERGOT ALKALOIDS AND AS INFLUENCING MIGRAINE*WILLIAM G. LENNOX, M.D., HILDEGARDE C. LEONHARDTWILLIAM G. LENNOX, M.D.Search for more papers by this author, HILDEGARDE C. LEONHARDTSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-4-663 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn about 90 per cent of patients suffering from an attack of migraine headache, the injection of ergotamine tartrate causes complete disappearance of the pain and other symptoms.1In the case of the more recently isolated alkaloid of ergot, ergonovine, clinical results are not so striking. In our 54 patients who received injection of the drug, pain was stopped in 39 per cent and was improved in a further 40 per cent.2The beneficial action of ergot seems to be specific for headaches of the migraine type.3These welcome therapeutic results led us to investigate the physiological effects of these...References1. LENNOX WG: The use of ergotamine tartrate in migraine, New Eng. Jr. Med., 1934, ccx, 1061. LENNOX, W. G., and VON STORCH, T. J. C.: Experience with ergotamine tartrate in 120 migraine patients, Jr. Am. Med. Assoc., 1935, cv, 169. CrossrefGoogle Scholar2. LENNOX WG: Ergonovine versus ergotamine as a terminator of migraine headaches. (In press.) Google Scholar3. LENNOXVON STORCHSOLOMON WGTJP: The effect of ergotamine tartrate on non-migrainous headaches, Am. Jr. Med. Sci., 1936, cxcii, 57. CrossrefGoogle Scholar4. LENNOXGIBBSGIBBS WGELFA: The effect of ergotamine tartrate on the cerebral circulation of man, Jr. Am. Pharm. Exper. Therap., 1935, liii, 113. Google Scholar5. HERRICK JF: The effect of ergotamine tartrate on blood flow and blood pressure in the femoral artery of the dog, Proc. Soc. Exper. Biol. and Med., 1933, xxx, 871. CrossrefGoogle Scholar6. VAN SLYKE DD: Notes on a portable form of the manometric gas apparatus and on certain points in the technique of its use, Jr. Biol. Chem., 1927, lxxiii, 121. CrossrefGoogle Scholar7. YOUMANSTRIMBLEFRANK JBWHH: The effect of ergotamine on the basal metabolism, circulation and blood sugar of normal persons and of patients with thyrotoxicosis, Arch. Int. Med., 1931, xlvii, 612. CrossrefGoogle Scholar8. GIBBSGIBBSLENNOX FAELWG: The cerebral blood flow in man as influenced by adrenalin, caffein, amyl nitrate and histamine, Jr. Am. Heart, 1935, x, 916. CrossrefGoogle Scholar9. EDMUNDSNELSON CWEE: Factors concerned in the polycythemia produced by the subcutaneous injection of epinephrine, Jr. Exper. Med., 1925, xli, 1. CrossrefGoogle Scholar10. POOLNASON JLGL: Cerebral circulation. XXXV. A comparison of the effect of ergotamine tartrate on the arteries in the pia, dura and skin of cats, Arch. Neurol. and Psych., 1935, xxxiii, 276. CrossrefGoogle Scholar11. GRAHAMWOLF JRHG: On the mechanism of migraine headache and the action of ergotamine tartrate, Jr. Clin. Invest., 1937, xvi, 660. Google Scholar12. POOLVON STORCHLENNOX JLTJWG: Effect of ergotamine tartrate on pressure of cerebrospinal fluid and blood during migraine headache, Arch. Int. Med., 1936, lvii, 32. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication July 29, 1937.From the Neurological Unit of the Boston City Hospital and the Department of Neurology of Harvard Medical School, Boston, Mass. The research was aided by the Josiah Macy, Jr. Foundation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCapillary studies in migraine; Effect of ergotamine tartrate and water diuresisThe mode of action of ergotamine tartrate in psychotic patients 1 October 1937Volume 11, Issue 4Page: 663-670KeywordsAlkaloidsDrugsMigraineNeurology Issue Published: 1 October 1937 PDF DownloadLoading ...