Update in Allergy and Immunology
Authors: David P. Huston
Journal: Annals of Internal Medicine (2006)

Updates19 September 2006Update in Allergy and ImmunologyDavid P. Huston, MDDavid P. Huston, MDFrom Baylor College of Medicine, Houston, Texas.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-6-200609190-00009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In this Update, 10 academic allergy and immunology specialists helped select, from 20 journals, papers published in 2005 that provided the greatest insight into the mechanisms and treatment of allergic and immune disorders. The papers are categorized into 3 themes: mechanisms of allergic disease, with insight into pathogenesis or treatment; therapy for allergic disease, including controversial or novel approaches for allergy treatment; and immune deficiency, with particular insight into the pathogenesis of common variable immunodeficiency (CVID).Mechanisms of Allergic DiseasePollen-Induced Oxidative Stress Contributes to Allergic Airway Inflammation ...References1. Taylor PE, Flagan RC, Valenta R, Glovsky MM. Release of allergens as respirable aerosols: a link between grass pollen and asthma. J Allergy Clin Immunol. 2002;109:51-6. [PMID: 11799365] CrossrefMedlineGoogle Scholar2. Busse WW, Lemanske RF. Asthma. N Engl J Med. 2001;344:350-62. [PMID: 11172168] CrossrefMedlineGoogle Scholar3. Akbari O, Faul JL, Hoyte EG, Berry GJ, Wahlström J, Kronenberg M, et al. CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. N Engl J Med. 2006;354:1117-29. [PMID: 16540612] CrossrefMedlineGoogle Scholar4. Foreman J, Demidchik V, Bothwell JH, Mylona P, Miedema H, Torres MA, et al. Reactive oxygen species produced by NADPH oxidase regulate plant cell growth. Nature. 2003;422:442-6. [PMID: 12660786] CrossrefMedlineGoogle Scholar5. Liu YJ. Thymic stromal lymphopoietin: master switch for allergic inflammation. J Exp Med. 2006;203:269-73. [PMID: 16432252] CrossrefMedlineGoogle Scholar6. Yoo J, Omori M, Gyarmati D, Zhou B, Aye T, Brewer A, et al. Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin. J Exp Med. 2005;202:541-9. [PMID: 16103410] CrossrefMedlineGoogle Scholar7. Zhou B, Comeau MR, De Smedt T, Liggitt HD, Dahl ME, Lewis DB, et al. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol. 2005;6:1047-53. [PMID: 16142237] CrossrefMedlineGoogle Scholar8. Pauwels RA, Pedersen S, Busse WW, Tan WC, Chen YZ, Ohlsson SV, et al. Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial. Lancet. 2003;361:1071-6. [PMID: 12672309] CrossrefMedlineGoogle Scholar9. National Asthma Education and Prevention Program Expert Panel Report 2: Guidelines for the Diagnosis and Management of Asthma. NIH publication no. 97-4051. Bethesda, MD: National Institutes of Health; 1997. Google Scholar10. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. NIH publication no. 02-3659. Bethesda, MD: National Institutes of Health; 2002. Google Scholar11. Siraganian RP. Mast cell signal transduction from the high-affinity IgE receptor. Curr Opin Immunol. 2003;15:639-46. [PMID: 14630197] CrossrefMedlineGoogle Scholar12. Zhang K, Kepley CL, Terada T, Zhu D, Perez H, Saxon A. Inhibition of allergen-specific IgE reactivity by a human Ig Fcgamma-Fcepsilon bifunctional fusion protein. J Allergy Clin Immunol. 2004;114:321-7. [PMID: 15316510] CrossrefMedlineGoogle Scholar13. Kinet JP. A new strategy to counter allergy. N Engl J Med. 2005;353:310-2. [PMID: 16034020] CrossrefMedlineGoogle Scholar14. Cunningham-Rundles C, Bodian C. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol. 1999;92:34-48. [PMID: 10413651] CrossrefMedlineGoogle Scholar15. Schneider P. The role of APRIL and BAFF in lymphocyte activation. Curr Opin Immunol. 2005;17:282-9. [PMID: 15886118] CrossrefMedlineGoogle Scholar16. Lee WI, Torgerson TR, Schumacher MJ, Yel L, Zhu Q, Ochs HD. Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome. Blood. 2005;105:1881-90. [PMID: 15358621] CrossrefMedlineGoogle Scholar17. Straus SE, Sneller M, Lenardo MJ, Puck JM, Strober W. An inherited disorder of lymphocyte apoptosis: the autoimmune lymphoproliferative syndrome. Ann Intern Med. 1999;130:591-601. [PMID: 10189330] LinkGoogle Scholar18. Hull KM, Drewe E, Aksentijevich I, Singh HK, Wong K, McDermott EM, et al. The TNF receptor-associated periodic syndrome (TRAPS): emerging concepts of an autoinflammatory disorder. Medicine (Baltimore). 2002;81:349-68. [PMID: 12352631] CrossrefMedlineGoogle Scholar19. Sharpe AH, Freeman GJ. The B7-CD28 superfamily. Nat Rev Immunol. 2002;2:116-26. [PMID: 11910893] CrossrefMedlineGoogle Scholar20. Grimbacher B, Hutloff A, Schlesier M, Glocker E, Warnatz K, Dräger R, et al. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat Immunol. 2003;4:261-8. [PMID: 12577056] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Baylor College of Medicine, Houston, Texas.Disclosures: None disclosed.Corresponding Author: David P. Huston, MD, Baylor College of Medicine, Biology of Inflammation Center, One Baylor Plaza, BCM 285, Houston, TX 77030; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 September 2006Volume 145, Issue 6Page: 454-458KeywordsAllergy and immunologyAntigensAsthmaChemokinesImmune responseInflammationMast cellsMutationPollenProteins ePublished: 19 September 2006 Issue Published: 19 September 2006 CopyrightCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...