tbuckley/cabot-search huggingface dataset:
SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive mantle cell lymphoma
Authors: Maria Carmela Vegliante, Jara Palomero, Patricia Pérez-Galán, Gaël Roué, Giancarlo Castellano, Alba Navarro, Guillem Clot, Alexandra Moros, Helena Suárez-Cisneros, Sílvia Beà, Luis Hernández, Anna Enjuanes, Pedro Jares, Neus Villamor, Dolors Colomer, José Ignacio Martín-Subero, Elias Campo, Virginia Amador
Journal: Blood (2013)
Immunotherapy, Advanced Cancer, and Hyposplenism
Authors: HERMANN F. HOCHHUTH
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 August 1987Immunotherapy, Advanced Cancer, and HyposplenismHERMANN F. HOCHHUTH, M.D.HERMANN F. HOCHHUTH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-2-258_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Is immunotherapy (1) more effective in splenectomized patients? I report the case of a patient with advanced carcinoma of the pancreas, who had been splenectomized 5.5 years earlier, treated with surgery and subsequent vaccination (2) with bacille Calmette-Guérin, with remission of tumor for more than 7 years.A 44-year-old previously cholecystectomized woman with chronic pancreatitis underwent pancreas tail resection, Puestow procedure, and a splenectomy in 1974. Pain still continued, and when icterus developed in February 1980, subtotal pancreas resection with Whipple procedure was necessary. An advanced mucigenous cystadenocarcinoma of the pancreas had widely infiltrated the wall of...References1. LONGO D. Monoclonal antibodies, pp 427-9. In: FAUCI AS, moderator. Immunomodulators in clinical medicine. Ann Intern Med. 1987; 106:421-33. MedlineGoogle Scholar2. MIESCHER P. Immunstimulation, Immunpotenzierung als therapeutisches Prinzip. In: 88. Kongress Deutsche Gesellschaft fur Innere Medizin. Munich: J. F. Bergmann Verlag; 1982:500-7. Google Scholar3. VAN DYKE J, STANLEY R, and BERLAND L. Pancreatic imaging. Ann Intern Med. 1985;102:212-7. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HERMANN F. HOCHHUTH, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1987Volume 107, Issue 2 Page: 258-258 Keywords Bacille calmette guerin Cancer immunotherapy Chronic pancreatitis Pancreas Splenectomy Surgery ePublished: 1 December 2008 Issue Published: 1 August 1987 PDF downloadLoading ...
Treatment for multiple myeloma. Combination chemotherapy with different melphalan dose regimens
Authors: R. Alexanian
Journal: JAMA (1969)

Of 183 patients with multiple myeloma treated with melphalan, 43% demonstrated an objective response. Of the evaluable cases, 70% of the patients responded to combination therapy with melphalan and prednisone, 35% to intermittent melphalan therapy, and 19% to daily melphalan therapy. Symptomatic manifestations of disease decreased in almost all responding patients. The degree of remission was superior with melphalan-prednisone therapy since serum myeloma globulin peaks disappeared more frequently from the electrophoresis scan. In patients producing only λ Bence Jones proteins, azotemia was more frequent, the incidence of response was low, and survival was short. Median survival for patients treated with melphalan-prednisone was about six months longer than the survival of patients treated with melphalan alone. Results support the use of intermittent courses of concurrent chemotherapy with large doses of melphalan and prednisone in patients with multiple myeloma.
Profound hypokalaemia in a patient with Creutzfeldt-Jakob disease
Authors: A. M Abdelgabar
Journal: Journal of the Royal Society of Medicine (2002)

In Creutzfeldt—Jakob disease (CJD) routine biochemical tests are usually within normal limits. A few patients have had slight increases in liver enzymes and bilirubin, or persistent hypercalcaemia1. Hypokalaemia does not seem to have been reported.
The adenosine deaminase acting on RNA 1 p150 isoform is involved in the pathogenesis of dyschromatosis symmetrica hereditaria
Authors: J.Y. Zhang, X.D. Chen, Z. Zhang, H.L. Wang, L. Guo, Y. Liu, X.Z. Zhao, W. Cao, Q.H. Xing, F.M. Shao
Journal: British Journal of Dermatology (2013)

Journal Article The adenosine deaminase acting on RNA 1 p150 isoform is involved in the pathogenesis of dyschromatosis symmetrica hereditaria Get access J.Y. Zhang, J.Y. Zhang Children's Hospital and Institutes of Biomedical Sciences Fudan University 130 Dong‐An Road Shanghai 200032 China Search for other works by this author on: Oxford Academic Google Scholar X.D. Chen, X.D. Chen Ninth People's Hospital Shanghai Jiao Tong University School of Medicine 639 Zhi‐Zao‐Ju Road Shanghai 200011 China Search for other works by this author on: Oxford Academic Google Scholar Z. Zhang, Z. Zhang Ninth People's Hospital Shanghai Jiao Tong University School of Medicine 639 Zhi‐Zao‐Ju Road Shanghai 200011 China Search for other works by this author on: Oxford Academic Google Scholar H.L. Wang, H.L. Wang Children's Hospital and Institutes of Biomedical Sciences Fudan University 130 Dong‐An Road Shanghai 200032 China Search for other works by this author on: Oxford Academic Google Scholar L. Guo, L. Guo Children's Hospital and Institutes of Biomedical Sciences Fudan University 130 Dong‐An Road Shanghai 200032 China Search for other works by this author on: Oxford Academic Google Scholar Y. Liu, Y. Liu Children's Hospital and Institutes of Biomedical Sciences Fudan University 130 Dong‐An Road Shanghai 200032 China Search for other works by this author on: Oxford Academic Google Scholar X.Z. Zhao, X.Z. Zhao Children's Hospital and Institutes of Biomedical Sciences Fudan University 130 Dong‐An Road Shanghai 200032 China Search for other works by this author on: Oxford Academic Google Scholar W. Cao, W. Cao Zhengzhou People's Hospital 33 Huanghe Road Zhengzhou 450053 China Correspondence Wei Cao. E‐mail: caoweiyu@hotmail.com Qinghe Xing. E‐mail: qhxing@fudan.edu.cn Search for other works by this author on: Oxford Academic Google Scholar Q.H. Xing, Q.H. Xing Children's Hospital and Institutes of Biomedical Sciences Fudan University 130 Dong‐An Road Shanghai 200032 China Search for other works by this author on: Oxford Academic Google Scholar F.M. Shao F.M. Shao Department of Urology People's Hospital of Henan Province 7 Wei‐Wu Road Zhengzhou 450000 China Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 169, Issue 3, 1 September 2013, Pages 637–644, https://doi.org/10.1111/bjd.12401 Published: 01 September 2013
Latrogenic Disorders of the Fetus, Infant, and Child
Authors: David H. Baker
Journal: JAMA (1986)

E. George Kassner's book,<i>Iatrogenic Disorders of the Fetus, Infant, and Child</i>, volume 1, reflects a career-long interest in the result of physicians' actions on their patients. The definition developed here for<i>iatrogenic</i>is broad enough to cover all possible adverse effects of either diagnosis or treatment, both avoidable and unavoidable. This in itself is almost an impossible task, as there seems to be no end to the opportunities to do mischief to our patients. Dr Kassner has made a brave attempt. The volume is divided into eight sections dealing with different organ systems and age groups. The fetus and infant are stressed. The section on the fetus includes a good overview of maternal toxins, a historical review of interventional procedures (largely intrauterine transfusions), and a good discussion (with references) of fetal radiation exposure and its consequences. The section on birth trauma details the causes and complications of asphyxia at
Therapeutic levels of human protein C in rats after retroviral vector-mediated hepatic gene therapy.
Authors: S R Cai, S C Kennedy, W M Bowling, M W Flye, K P Ponder
Journal: Journal of Clinical Investigation (1998)

Protein C deficiency results in a thrombotic disorder that might be treated by expressing a normal human protein C (hPC) gene in patients. An amphotropic retroviral vector with a liver-specific promoter and the hPC cDNA was delivered to rat hepatocytes in vivo during liver regeneration. Expression of hPC varied from 55 to 203 ng/ml (1.3-5.0% of normal) for 2 wk after transduction. Expression increased to an average of 900 ng/ml (22% of normal) in some rats and was maintained at stable levels for 1 yr. All of these rats developed anti-hPC antibodies and exhibited a prolonged hPC half-life in vivo. The hPC was functional as determined by a chromogenic substrate assay after immunoprecipitation. We conclude that most rats achieved hPC levels that would prevent purpura fulminans, and that hepatic gene therapy might become a viable treatment for patients with severe homozygous hPC deficiency. Anti-hPC antibodies increased the hPC half-life and plasma levels in some rats, but did not interfere with its functional activity. Thus, the development of antibodies against a plasma protein does not necessarily abrogate its biological effect in gene therapy experiments.
Homozygosity for Factor V Leiden Leads to Enhanced Thrombosis and Atherosclerosis in Mice
Authors: Daniel T. Eitzman, Randal J. Westrick, Yuechun Shen, Peter F. Bodary, Shufang Gu, Sara L. Manning, Sarah L. Dobies, David Ginsburg
Journal: Circulation (2005)

Background— Activated protein C resistance due to factor V Leiden (FVL) is a common genetic risk factor for venous thrombosis in humans. Although the impact of FVL on the development of venous thrombosis is well established, its effect on arterial thrombosis and atherosclerosis is controversial. Methods and Results— To determine the effect of the FVL mutation on arterial thrombosis in the mouse, wild-type ( Fv +/+ ), heterozygous FVL ( Fv Q /+ ), and homozygous FVL ( Fv Q/Q ) mice underwent photochemical carotid arterial injury to induce occlusive thrombosis. Fv Q/Q mice formed occlusive thromboses 27±3 minutes (n=7) after the onset of injury, which was significantly shorter than that observed for Fv +/+ mice (56±7 minutes, n=9, P &lt;0.01), whereas Fv Q /+ mice (41±7 minutes, n=5) were intermediate ( P =0.5, compared with Fv +/+ ). To determine the source of FVL relevant to the enhanced vascular thrombosis, bone marrow transplantation experiments were performed between Fv +/+ and Fv Q/Q mice. Fv Q/Q mice transplanted with Fv +/+ bone marrow formed occlusive thromboses at 35±5 minutes (n=7, P &lt;0.05 compared with Fv +/+ mice), whereas Fv +/+ mice transplanted with Fv Q/Q bone marrow occluded at 59±7 minutes (n=6, P &lt;0.001 compared with Fv Q/Q mice). To assess the effect of the FVL mutation on the development of atherosclerosis, Fv Q/Q mice were crossed with the atherosclerosis-prone apolipoprotein E (ApoE)–deficient strain ( ApoE −/− ) to generate Fv Q/Q ,ApoE −/− mice. By 52 weeks of age, Fv Q/Q ,ApoE −/− mice (n=8) had developed more aortic atherosclerosis (40±6% lesion area) compared with Fv +/+ ,ApoE −/− mice (15±3% lesion area; n=12, P &lt;0.02). Conclusions— In conclusion, homozygosity for the FVL mutation in mice leads to enhanced arterial thrombosis and atherosclerosis. The source of the FVL leading to accelerated thrombosis appears to be circulating, non–platelet-derived plasma FVL.
POST-HOSPITAL OUTCOMES IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION COMPLICATED BY CARDIOGENIC SHOCK: FINDINGS FROM THE ACTION REGISTRY-GWTG
Authors: Rashmee Shah, Tracy Wang, Anita Chen, Laine Thomas, Benjamin Scirica, Timothy Henry, Nadia Sutton, James Fang, James de Lemos, Christopher Granger
Journal: Journal of the American College of Cardiology (2015)
Transformation of Cardiovascular Health
Authors: Clyde W. Yancy
Journal: Circulation (2010)

the American Heart Association's Scientific Sessions 2009.Thank you for being here.Today, you are part of the phenomenal tapestry of those attending this meeting.As I look out in the audience, I see accomplished and new basic and clinical scientists, clinicians, clinical and research nurses, and allied health professionals.I marvel at the collection of AHA past presidents and chairpersons, leaders of our partner national and international professional and volunteer health organizations, and my colleagues here from the American College of Cardiology.I embrace the volunteers, patients, and family members who are here today; and I appreciate the business professionals, innovators, and media who share our interest in cardiovascular diseases and stroke.Welcome.We have all come together at Scientific Sessions for a singular purpose: to share our interest, our curiosity, our passion, and our intent to "build healthier lives, free of cardiovascular diseases and stroke."Today, I will address the transformation of cardiovascular health.Health care is changing.One year ago, we realized the dawning of epic change-specifically, the potential transformation of American health care.Given the enormity of this moment, we were galvanized to contribute proactively to healthcare reform.
The Return of the Medicine Show
Authors: William R. Barclay
Journal: JAMA (1977)

There was a period when traveling medicine shows provided promises for the ill and entertainment for everybody. They peddled elixirs and pills and proclaimed that they could cure everything from insomnia to impotence. The performance of the pitchman was just as important as the pills peddled. He first created a carnival atmosphere that counteracted the feelings of discouragement and depression that are associated with illness. He then generated hope by lavish promises backed up by anecdotal testimonials. Finally, he established conviction of worth by disclosing that the remedy was one of "nature's cures," a natural substance extracted from plants or animals. All this set the stage not only for the sale of a remedy, but also for ensuring its placebo effect. Although the placebo effect is no better understood today than it was then, its existence cannot be doubted. Double-blind, controlled clinical trials have repeatedly demonstrated that a placebo will
Evaluation of Treatment-Associated Inflammatory Response on Diffusion-Weighted Magnetic Resonance Imaging and 2-[18F]-Fluoro-2-Deoxy-<scp>d</scp>-Glucose-Positron Emission Tomography Imaging Biomarkers
Authors: Craig J. Galbán, Mahaveer S. Bhojani, Kuei C. Lee, Charles R. Meyer, Marcian E. Van Dort, Kyle K. Kuszpit, Robert A. Koeppe, Rajesh Ranga, Bradford A. Moffat, Timothy D. Johnson, Thomas L. Chenevert, Alnawaz Rehemtulla, Brian D. Ross
Journal: Clinical Cancer Research (2010)

Functional imaging biomarkers of cancer treatment response offer the potential for early determination of outcome through the assessment of biochemical, physiologic, and microenvironmental readouts. Cell death may result in an immunologic response, thus complicating the interpretation of biomarker readouts. This study evaluated the temporal effect of treatment-associated inflammatory activity on diffusion magnetic resonance imaging and 2-[(18)F]-fluoro-2-deoxy-D-glucose-positron emission tomography imaging (FDG-PET) biomarkers to delineate the effects of the inflammatory response on imaging readouts.Rats with intracerebral 9L gliosarcomas were separated into four groups consisting of control, an immunosuppressive agent dexamethasone (Dex), 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), and BCNU+Dex. Animals were imaged using diffusion-weighted magnetic resonance imaging and FDG-PET at 0, 3, and 7 days posttreatment.In the BCNU- and BCNU+Dex-treated animal groups, diffusion values increased progressively over the 7-day study period to approximately 23% over baseline. The FDG percentage change of standard uptake value decreased at day 3 (-30.9%) but increased over baseline levels at day 7 (+20.1%). FDG-PET of BCNU+Dex-treated animals were found to have percentage of standard uptake value reductions of -31.4% and -24.7% at days 3 and 7, respectively, following treatment. Activated macrophages were observed on day 7 in the BCNU treatment group with much fewer found in the BCNU+Dex group.Results revealed that treatment-associated inflammatory response following tumor therapy resulted in the accentuation of tumor diffusion response along with a corresponding increase in tumor FDG uptake due to the presence of glucose-consuming activated macrophages. The dynamics and magnitude of potential inflammatory response should be considered when interpreting imaging biomarker results.
Immunotherapy With Allergens
Authors: Peter S. Creticos
Journal: JAMA (1992)

ALLERGEN immunotherapy is the process by which increasing doses of allergen are injected subcutaneously over time as a treatment to prevent allergic symptoms that usually occur on exposure to allergen. The effects of this therapy on the immunologic processes ascribed to allergic responses have been studied in great detail. <h3>EFFECTS OF IMMUNOTHERAPY ON THE INFLAMMATION ASSOCIATED WITH ALLERGIC REACTIONS</h3> A number of different tools have allowed an in-depth look at the effects of immunotherapy on the cellular events, inflammatory responses, and immunologic changes that occur in allergic diseases. The nasal challenge model<sup>1</sup>has provided a means of investigating the effects of immunotherapy at both the clinical and cellular levels. Typically, standardized inhalation of allergen (nasal provocation) induces clinical symptoms of allergic rhinitis that correlate with the appearance of various inflammatory mediators (histamine, kinins, prostaglandins, leukotrienes) in the nasal secretions. Stepwise increases of the (pollen) challenge dose induces incremental increases
Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation
Authors: C H Halsted, J Villanueva, C J Chandler, S P Stabler, R H Allen, L Muskhelishvili, S J James, L Poirier
Journal: Hepatology (1996)

Chronic alcoholism is associated with increased cancer risk that may be related to ethanol-induced alterations in methionine and deoxynucleotide metabolism. These metabolic relationships were studied in micropigs fed diets for 12 months that contained 40% ethanol or cornstarch control with adequate folate. Ethanol feeding altered methionine metabolism without changing mean terminal liver folate levels. After initial equilibration to diet, ethanol feeding significantly increased monthly serum homocysteine levels while reducing serum methionine levels over the time course of the experiment. After 12 months, hepatic methionine synthase activity and the ratio of S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH) were significantly reduced in ethanol-fed animals, whereas the ratio of liver deoxyuridine triphosphate (dUTP) to deoxythymidine triphosphate (dTTP) was increased and correlated inversely with methionine synthase activity. These findings were associated with increased frequency of hepatocytes with apoptotic bodies and positivity for proliferating cell nuclear antigen (PCNA) in livers from ethanol-fed minipigs. These studies suggest that chronic ethanol feeding perturbs methionine metabolism by impairment of methionine synthase activity, resulting in deoxynucleoside triphosphate (dNTP) imbalance, increased apoptosis, and regenerative proliferation. These biochemical alterations may provide a promoting environment for carcinogenesis during long-term ethanol exposure.
Penicillin in Ophthalmia Neonatorum
Authors: A. Sorsby
Journal: BMJ (1947)

In an earlier communication (Sorsby and Hoffa, 1945) it was shown that penicillin locally is highly efficacious in ophthalmia neonatorum.Consistent results could be obtained when drops in a concentration of 2,500 units per ml.were used, lower concentrations being rather erratic in their effect.The frequency of application was also shown to be of significance (Sorsby, 1945a(Sorsby, , 1945b)).Clinical cure was obtained more readily when drops were used at half-hourly instead of at hourly intervals, and readier still when the intervals were reduced to five minutes.Any tendency to pus formation was then generally suppressed within half an hour to three hours (by the instillation of six to 30 applications).When there was no longer any discharge, instillation of penicillin drops was continued at half-hourly intervals for six to 12 hours.At the end of this time a clinical cure was usually obtained, and penicillin was continued hourly for 12 hours and two- hourly for a further 24 hours.It was found that all the common causal organisms of ophthalmia neonatorum, in- cluding the virus of inclusion blennorrhoea, responded to penicillin, though there appeared to be a varying degree of susceptibility of the different exciting organisms.The present series of 232 cases were observed at the ophthalmia neonatorum unit at White Oak Hospital from May 8, 1945, to March 10, 1947.Local Treatment with Penicillin in Watery Solution at Five-minute IntervalsTo the 25 previously reported cases treated at five-minute intervals 30 more can now be added.Table I sets outTABLE I.-Commercial Penicillin 2,500 Units per ml. at Five-minute Initervals Initially.Time taken for Clinical Cure: in Relation to Severity and Distribution of the Affection No. of Clinical Cure in Hours for Each Case Cases Mild Unilateral 2 2, 1 Bilateral .. 5
Adjuvant treatment for colorectal cancer
Authors: M. L Slevin
Journal: BMJ (1996)

No more room for nihilism

It is now over five years since the publication of two randomised trials showing that fluorouracil and levamisole reduced the relapse rate by 40% and mortality by a third in patients with node positive colorectal cancer.1 2 The final report of these data was recently published, showing 168 deaths in control patients versus only 121 in patients who received adjuvant treatment (P<0.005).3 Despite these data, a recent survey of oncologists and surgeons in Britain showed that most oncologists offered adjuvant chemotherapy to appropriate patients while many surgeons remained sceptical (R Grey, personal communication).

The combination of fluorouracil and folinic acid has proved superior to fluorouracil alone in patients with advanced colorectal cancer.4 The Canadian and Eurpean consortium trial (IMPACT) compared adjuvant treatment with high dose fluorouracil and folinic acid with no treatment in nearly 1500 patients; it showed a 22% reduction in mortality, predominantly in patients with Dukes's type C colon cancer.5 A similar but much smaller Italian study showed a 39% …
GMC reprimands doctor for research fraud
Authors: O. Dyer
Journal: BMJ (2003)

Goran Jamal, a neurophysiologist well known for his work on the Gulf war syndrome and organophosphate poisoning, has been reprimanded by the General Medical Council after being found guilty of research fraud in a drug trial.

The professional conduct committee of the GMC found Dr Jamal, aged 49, guilty of serious professional misconduct for falsifying his results in a multicentre trial of the drug Tarabetic, also known as Efamol, a constituent of evening primrose oil, intended for the treatment of diabetic peripheral neuropathy. Having played a major role in the preliminary work on the drug, …