Cerebral Gigantism—Inappropriate Secretion of Growth Hormone?
Authors: WILL G. RYAN
Journal: Annals of Internal Medicine (1967)

Editorial Notes1 July 1967Cerebral Gigantism—Inappropriate Secretion of Growth Hormone?WILL G. RYAN, M.D.WILL G. RYAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-1-212 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptElsewhere in this issue of the ANNALS, Ludwig, Chaykin, and Escueta (1) describe an unusual patient whose clinical features resemble those of a group reported by Sotos and associates (2) in 1964. Sporadic case reports have appeared (3), and recently Poznanski and Stephenson (4) described the radiographic features of ten additional patients.The syndrome of cerebral gigantism consists essentially of excessively rapid growth in childhood (probably beginning prenatally) with development of acromegalic features and a nonprogressive cerebral disorder associated with mental retardation and communicating hydrocephalus, in the presence of a radiologically normal sella turcica. The characteristic craniofacial configuration consists of...References1. LUDWIGCHAYKINESCUETA GDLBAV: Cerebral gigantism with intermittent fractional hypopituitarism and normal sella turcica. Ann. Intern. Med. 67: 123, 1967. LinkGoogle Scholar2. SOTOSDODGEMUIRHEADCRAWFORDTALBOT JFPRDJDNB: Cerebral gigantism in childhood. A syndrome of excessively rapid growth with acromegalic features and a nonprogressive neurologic disorder. New Eng. J. Med. 271: 109, 1964. CrossrefMedlineGoogle Scholar3. KJELLMAN B: Cerebral gigantism. Acta Paediat. Scand. 54: 603, 1965. CrossrefMedlineGoogle Scholar4. POZNANSKISTEPHENSON AKJM: Radiographic findings in hypothalamic acceleration of growth associated with cerebral atrophy and mental retardation. Radiology 88: 446, 1967. CrossrefMedlineGoogle Scholar5. GOLDMANCAHILLTHORN JKGFGW: Gigantism with hypopituitarism. Amer. J. Med. 34: 407, 1963. CrossrefMedlineGoogle Scholar6. HARRISREEDFAWCETT GWMCP: Hypothalamic releasing factors and the control of anterior pituitary function. Brit. Med. Bull. 22: 266, 1966. CrossrefMedlineGoogle Scholar7. ZIMMERMANWHITEDAUGHADAYGOETZ TSMGWHFC: Hypopituitarism with normal or increased height. Amer. J. Med. 42: 146, 1967. CrossrefMedlineGoogle Scholar8. HUNTERRIGAL WMWM: The diurnal pattern of plasma growth hormone concentration in children and adolescents. J. Endocr. 34: 147, 1966. CrossrefMedlineGoogle Scholar9. LARONPERTZELANMANNHEIMER ZAS: Genetic pituitary dwarfism with high serum concentration of growth hormone. Israel J. Med. Sci. 2: 152, 1966. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Presbyterian-St. Luke's Hospital University of Illinois College of Medicine Chicago, Ill. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMetal Transfer and Mass Flow in the Weld Pool 1 July 1967Volume 67, Issue 1Page: 212-213KeywordsGrowth hormoneHydrocephalusIntellectual disability Issue Published: 1 July 1967 PDF downloadLoading ...