Chancroid and Haemophilus ducreyi
Authors: ALLAN R. RONALD
Journal: Annals of Internal Medicine (1985)

Editorials1 May 1985Chancroid and Haemophilus ducreyiALLAN R. RONALD, M.D., FRANCIS A. PLUMMER, M.D.ALLAN R. RONALD, M.D.Search for more papers by this author, FRANCIS A. PLUMMER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-5-705 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptChancroid, one of the six classic venereal diseases, was first described by Brassereau in 1852 (1). He differentiated the "hard" chancre of primary syphilis from the "ulcus molle" of chancroid by showing that autoinoculation with ulcer exudate produced a new ulcer in patients with chancroid but not in patients with primary syphilis. In 1889, Ducrey (2) described a chaining streptobacillary organism in the exudate of ulcers produced by autoinoculation. Subsequent progress in our understanding of this organism has been very slow, becauseHaemophilus ducreyiis fastidious and chancroid has ceased to be a major health problem in industrialized countries. However,...References1. BRASSEREAU L. In: BUMSTEAD FJ. The Pathology and Treatment of Venereal Diseases. Philadelphia: Lea & Febiger; 1866:39-45. Google Scholar2. DUCREY A. Experimentelle Untersuchungen uber den Ansteckungsstoff des weichen Schankers und uber die Bubonen. Monatsh Prakt Dermatol. 1889;9:387-405. Google Scholar3. HANSCHELL H. Sulfanilamide in the treatment of chancroid. Lancet. 1938;1:886-8. CrossrefGoogle Scholar4. HAMMONDSLUTCHUKSCATLIFFSHERMANWILTRONALD GMJEJA. Epidemiologic, clinical, laboratory, and therapeutic features of an urban outbreak of chancroid in North America. Rev Infect Dis. 1980;2:867-9. CrossrefMedlineGoogle Scholar5. HAMMONDLIANWILTRONALD GCJA. Comparison of specimen collection and laboratory techniques for isolation of Haemophilus ducreyi. J Clin Microbiol. 1978;7:39-43. CrossrefMedlineGoogle Scholar6. HANDSFIELDTOTTENFENNELFALKOWHOLMES HPCSK. Molecular epidemiology of Haemophilus ducreyi infections. Ann Intern Med. 1981;95:315-8. LinkGoogle Scholar7. KRAUSKAUFMANALBRITTONTHORNSBERRYBIDDLE SHWCS. Chancroid therapy: a review of cases confirmed by culture. Rev Infect Dis. 1982;4(suppl):S843-56. CrossrefMedlineGoogle Scholar8. Chancroid—California. MMWR. 1982;31:173-5. MedlineGoogle Scholar9. CHAPELBROWNJEFFRIESSTEWART TWCJ. How reliable is the morphologic diagnosis of penile ulcerations? Sex Transm Dis. 1977;4:150-2. CrossrefMedlineGoogle Scholar10. KRAUSWERMANBIDDLESOTTNEKEWING SBJFE. Pseudogranuloma inguinale caused by Haemophilus ducreyi. Arch Dermatol. 1982;118:494-7. CrossrefMedlineGoogle Scholar11. PLUMMERD'COSTANSANZEDYLEWSKIKARASIRARONALD FLHJPA. Epidemiology of chancroid and Haemophilus ducreyi in Nairobi, Kenya. Lancet. 1983;2:1293-5. CrossrefMedlineGoogle Scholar12. NSANZEPLUMMERMAGGWA HFA. Comparison of media for the primary isolation of Haemophilus ducreyi. Sex Transm Dis. 1984;11:6-9. CrossrefMedlineGoogle Scholar13. SOTTNEKBIDDLEKRAUSWEAVERSTEWART FJSRJ. Isolation and identification of Haemophilus ducreyi in a clinical study. J Clin Microbiol. 1980;12:170-4. CrossrefMedlineGoogle Scholar14. PLUMMERNSANZED'COSTA FHL. Short-course and single-dose antimicrobial therapy for chancroid in Kenya: studies with rifampin alone and in combination with trimethoprim. Rev Infect Dis. 1983;5(suppl 3):S565-72. CrossrefMedlineGoogle Scholar15. MARMAR J. The management of resistant chancroid in Vietnam. J Urol. 1972;107:807-8. CrossrefMedlineGoogle Scholar16. FASTNSANZED'COSTA MHL. Antimicrobial therapy of chancroid: an evaluation of five treatment regimens correlated with in vitro sensitivity. Sex Transm Dis. 1983;10:1-6. CrossrefMedlineGoogle Scholar17. FASTNSANZED'COSTA MHL. Treatment of chancroid by clavulanic acid with amoxycillin in patients with β-lactamase-positive Haemophilus ducreyi infection. Lancet. 1982;2:509-11. CrossrefMedlineGoogle Scholar18. BRUNTONMEIEREHRMANMACLEANSLANEYALBRITTON JMNILW.Molecular epidemiology of β-lactamase-specifying plasmids of Haemophilus ducreyi. Antimicrob Agents Chemother. 1982;21:857-63. CrossrefMedlineGoogle Scholar19. ANDERSONALBRITTONBIDDLEJOHNSON BWJS. Common β-lactamase-specifying plasmid in Haemophilus ducreyi and Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1984;25:296-7. CrossrefMedlineGoogle Scholar20. BRUNTONCLAREEHRMANMEIER JDNM. Evolution of antibiotic resistance plasmids in Neisseria gonorrhoeae and Haemophilus species. Clin Invest Med. 1983;6:221-8. MedlineGoogle Scholar21. ALBRITTONBRUNTONSLANEYMACLEAN WJLI. Plasmidmediated sulfonamide resistance in Haemophilus ducreyi. Antimicrob Agents Chemother. 1982;21:159-65. CrossrefMedlineGoogle Scholar22. ALBRITTONMACLEANSLANEYRONALDDENEER WILAH. Plasmid-mediated tetracycline resistance in Haemophilus ducreyi. Antimicrob Agents Chemother. 1984;24:187-9. CrossrefGoogle Scholar23. PLUMMERD'COSTANSANZE FLH. Antimicrobial therapy of chancroid: effectiveness of erythromycin. J Infect Dis. 1983;148:726-31. CrossrefMedlineGoogle Scholar24. PLUMMERNSANZED'COSTA FHL. Single-dose therapy of chancroid with trimethoprim-sulfametrole. N Engl J Med. 1983;309:67-71. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Manitoba Winnipeg, Manitoba Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA Genetic Polymorphism of FREM1 Is Associated with Resistance against HIV Infection in the Pumwani Sex Worker CohortHost Genetics and Resistance to HIV-1 InfectionImmunization with the Haemophilus ducreyi Hemoglobin Receptor HgbA with Adjuvant Monophosphoryl Lipid A Protects Swine from a Homologous but Not a Heterologous ChallengeOTHER HAEMOPHILUS SPECIES (APHROPHILUS, DUCREYI, HAEMOLYTICUS, INFLUENZAE BIOGROUP AEGYPTIUS, PARAHAEMOLYTICUS, AND PARAINFLUENZAE)Sexually Transmitted DiseasesInfectious DiseasesCharacterization of a transposon Tn916-generated mutant of Haemophilus ducreyi 35000 defective in lipooligosaccharide biosynthesisEnhanced recovery of Haemophilus ducreyi from clinical specimens by incubation at 33 versus 35 degrees CDetection of Haemophilus ducreyi lipooligosaccharide by means of an immunolimulus assayDERMATOLOGIC MANIFESTATIONS OF SEXUALLY TRANSMITTED DISEASES OTHER THAN HIVPartial characterization of the major lipooligosaccharide from a strain of Haemophilus ducreyi, the causative agent of chancroid, a genital ulcer disease.Chancroid and the Role of Genital Ulcer Disease in the Spread of Human RetrovirusesApproach to the Patient with Genital Ulcer DiseaseChancroidChancroid and Haemophilus ducreyiSexually Transmitted Urogenital DiseasesManagement of Genital InfectionsTheo ffice approach to the sexually transmitted diseases: Part IIImmunoblot analysis of antigens associated with Haemophilus ducreyi using serum from immunised rabbits.Antimicrobial Resistance to Sexually Transmitted Infections 1 May 1985Volume 102, Issue 5Page: 705-707KeywordsChancroidHaemophilusPrevention, policy, and public healthSexually transmitted diseasesSyphilisUlcers Issue Published: 1 May 1985 PDF DownloadLoading ...