tbuckley/cabot-search huggingface dataset:
Variants of the inosine triphosphate pyrophosphatase gene and relapse risk following treatment for HCV genotype 2/3
Authors: Chia‐Yen Dai, Wan‐Long Chuang, Ming‐Lung Yu
Journal: Hepatology (2014)

We read the article by Rembeck et al.1 with great interest reporting on the association between variations in the inosine triphosphate pyrophosphatase (ITPase) gene (ITPA) and sustained virological response (SVR) to pegylated interferon (Peg-IFN)-α2a/ribavirin (RBV) in hepatitis C virus (HCV) genotype 2/3 (G2/3)-infected patients. The researchers concluded that the role of the homo- or heterozygosity of Ars1127354 or Crs7270101 with reduced ITPase activity was associated with a higher SVR rate accompanied by a reduced risk of relapse among treatment-adherent patients. In Taiwanese G2-infected patients, we have previously reported, in our randomized, controlled trial, that an RVR was achieved by 86.7% of patients (86% and 87% in the 16- and 24-week groups, respectively),2 which suggested a higher RVR rate in a higher dose (78%-93%) of RBV than in a lower dose (62%-65%) of RBV per body weight.3, 4 Because the RVR was reported as the most important predictor of SVR in HCV G2-infected patients, even when interleukin-28B variants were taken into consideration,5, 6 and ITPA variants were reported not to increase SVR in G2/3-infected patients with higher dose of RBV,7 it is interesting to know whether the RVR is associated with ITPA variations and SVR in the present study of the NORDynamIC trial.4 Particularly, because RVR is currently the most important factor for individualized therapy for G2/3-infected patients, the effect of the ITPA variants on determining the duration of Peg-IFN/RBV therapy for patients with or without RVR deserves to be explored. Chia-Yen Dai, M.D., Ph.D.1,2,3 Wan-Long Chuang, M.D., Ph.D.1,2 Ming-Lung Yu, M.D., Ph.D.1,2 1Hepatobiliary Division Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung, Taiwan 2Hepatitis Center Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung, Taiwan 3Department of Occupational and Environmental Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung, Taiwan
The Persistence of High Body Sodium in Previously Edematous Patients with Heart Disease
Authors: HUGH J. CARROLL, SAUL J. FARBER
Journal: Circulation (1961)

Measurements of total body water and total exchangeable sodium were made in patients with heart disease rendered free of edema following congestive heart failure. The total exchangeable sodium in most of the patients was higher than would have been predicted on the basis of their body weight and total body water. Serial measurements showed that some patients gradually lose their excess sodium over a period of months without a loss of body water; others maintain an elevated ratio of body sodium to body weight and body sodium to body water for periods of at least several months. The data imply the possibility of significant quantities of osmotically inactive sodium in patients with heart disease.
THREE DIMENSIONAL QUANTITATIVE CORONARY ANGIOGRAPHY CAN DETECT RELIABLY ISCHEMIC CORONARY LESIONS BASED ON FRACTIONAL FLOW RESERVE
Authors: Woo-Young Chung, Seong-Hoon Lim, Yoshiki Matsuo, Rajiv Gulati, Gurpreet Sandhu, Amir Lerman
Journal: Journal of the American College of Cardiology (2012)
The Course of Reiter's Syndrome
Authors: G. W. Csonka
Journal: BMJ (1958)

Reiter's syndrome in its fully developed form is characterized by an association of non-specific urethritis, arthritis, conjunctivitis, and a number of less constant features (Reiter, 1916). Cases of urethritis and arthritis alone have a course indistinguishable from the full syn drome and are therefore included in this study. This leads to difficulties in nomenclature which will be resolved only when the aetiology of this condition becomes known.
HEMATURIA AND APPENDICITIS
Authors: ASTLEY P. C. ASHHURST
Journal: JAMA (1922)

It is more common for an attack of colic, due to stones in the right ureter, to be mistaken for an attack of acute appendicitis, and for the appendix to be mistakenly removed, than it is for an attack of appendicitis to be diagnosed as stone in the ureter, and operation postponed. That there may occasionally be justification for the latter course is apparent from the following case history, which is given as related by the patient himself. <h3>REPORT OF AUTHOR'S CASE</h3><h3>History.</h3> —L. G. W., Jr., aged 26, whose father had renal colic in his early thirties and passed stones, but has had no trouble since, whose brother died in 1904 from tuberculous meningitis, and whose sister had a thyroid gland removed two months previously, gave an otherwise excellent family history. The patient was said to have had a patulous foramen ovale for the first three months of life.
Reply to Michael Froehner and Manfred P. Wirth's Letter to the Editor re: Vincenzo Ficarra, Giacomo Novara, Raymond C. Rosen, et al. Systematic Review and Meta-analysis of Studies Reporting Urinary Continence Recovery After Robot-assisted Radical Prostatectomy. Eur Urol 2012;62:405–17
Authors: Vincenzo Ficarra, Giacomo Novara, Alexandre Mottrie, Timothy G. Wilson, Filiberto Zattoni, Francesco Montorsi
Journal: European Urology (2012)
Abstract 3881: BacMam-enabled biochemical and cellular assays to assess inhibitors of full-length receptor tyrosine kinases
Authors: Tina Hallis, Connie Lebakken, Laurie Reichling, Jason Ellefson, Coby Carlson, Spencer Hermanson, Kun Bi, Steve Riddle
Journal: Cancer Research (2012)

Abstract Receptor tyrosine kinases (RTKs) are important pharmacological targets in oncology. Current biochemical assays designed to assess compound efficacy utilize truncated forms of the kinase lacking the transmembrane or extracellular domains and fail to address how these domains might affect the observed pharmacology. Purification of the full-length recombinant receptor can be both costly and difficult to scale for large screening campaigns. Additionally, because of the generic nature of most substrates used in activity assays for RTKs, small amounts of contaminating kinases can interfere with assay results. Numerous cell-based assays for pathway analysis can also serve as readouts for these targets, but they are not a direct measurement of kinase activity. To address these limitations, we have employed a BacMam-mediated gene delivery system to express full-length receptor tyrosine kinases with C-terminal green fluorescent protein (GFP) fusions in a variety of cellular backgrounds. Expression of these full-length RTKs has enabled the development of two complimentary assay platforms. First, we present a competitive displacement assay that uses a europium (Eu)-labeled anti-GFP antibody and an AlexaFluor® 647-labeled active site probe to characterize compound binding to the RTK in a lysate-based format. Here, the GFP moiety serves as an epitope tag to allow for very specific and sensitive detection of compound binding, discriminating compounds with sub-nanomolar affinity. Using the same BacMam RTK-GFP constructs, we have also developed a simple, addition-only, cell-based method to detect auto-phosphorylation of the RTK via TR-FRET between a terbium (Tb)-labeled anti-phospho-tyrosine antibody and the GFP moiety. Together, these tools can be used in a high-throughput screening format with a fluorescence-based readout to more fully characterize compound efficacy against full-length RTKs expressed in native cellular contexts. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3881. doi:1538-7445.AM2012-3881
Evaluation of Comprehensive Program for Diabetes Care at Primary Health-Care Level
Authors: Urban Rosenqvist, Anita Carlson, Rolf Luft
Journal: Diabetes Care (1988)

The Swedish National Board of Health and Welfare published its first diabetes health-care program in 1977. The impact of the program was evaluated in the Stockholm County after 4 yr. The results showed that the educational program had reached ≥1 staff member in 86% of the 104 primary health-care centers (PHCCs). Several organizational changes had taken place as a result of the program. The 10 “best” PHCCs were compared with a random sample of the centers with regard to patient outcomes. Patients from the 10 best centers had gotten a more comprehensive education, were more knowledgeable about foot care, tested glucose more often, and used less medication. The metabolic control was the same for both groups of patients. The PHCC staffs reported the following roadblocks to change: lack of knowledge of diabetes care, insufficient cooperation between staff members, poor contact with specialists, and absence of guidelines for diabetes care. The staffs in the best centers spent twice as much time in staff meetings and continuing education as those from the random sample of centers. The findings led us to formulate a new strategy for the program. The main objective of the new approach is to create organizational changes within the centers. Thus, local knowledge and creativity can be utilized. Preliminary data demonstrate that 84% of the locally developed plans for reorganization of diabetes care had been accomplished within 1 yr.
AIDS in the Americas
Authors: Thomas C. Quinn, Fernando R.K. Zacarias, Ronald K. St. John
Journal: New England Journal of Medicine (1989)

Within the past decade, more than 100,000 persons with the acquired immunodeficiency syndrome (AIDS), or 70 percent of the worldwide total, have been described in 45 of the 46 countries in the Western Hemisphere. Two articles in this issue of the Journal highlight the growing public health problem of AIDS in the Americas and the controversial steps taken by one country to control the disease.1 , 2 serologic studies such as the report by Cortes et al.1 permit a better understanding of future directions and trends in the spread of human immunodeficiency virus Type 1 (HIV-1). On the basis of the best . . .
Making the Call
Authors: H. Gilbert Welch
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Physiological factors influencing serum bile acid levels
Authors: M. P. De Leon, G. M. Murphy, R. H. Dowling
Journal: Gut (1978)

This study defines the effects of fasting (prolongation of an overnight fast for a further four hours), feeding (the response to eating the three main ;solid' meals of the day), and cholecystokinin-induced gallbladder contraction (75-100 units of CCK given as a bolus intravenous injection) on serum individual bile acids in five to eight healthy control subjects. The serum conjugates of the two primary bile acids, cholic and chenodeoxycholic, were measured using sensitive specific radio-immunoassays. During fasting, there was no significant change in the levels of the serum individual bile acids (conjugates of cholate, 1.28 +/- 0.19; conjugates of chenodeoxycholate, 1.17 +/- 0.17 mumol/l). After breakfast, the serum conjugates of cholate and chenodeoxycholate increased significantly but thereafter the mean values remained high with less consistent responses to lunch and dinner, some subjects showing a peak and trough response to all three meals, while others showed a plateau response throughout the day. After breakfast, the serum chenodeoxycholate conjugates increased more rapidly (peak at 60 minutes when the concentration reached 2.07 +/- 0.30 mumol/l) and to a greater extent than the conjugates of cholate (peak at 90 minutes; 1.50 +/- 0.24 mumol/l). A similar pattern of results was seen after intravenous CCK, suggesting either preferential jejunal absorption of chenodeoxycholate conjugates and/or preferential hepatic clearance of cholate conjugates. These results provide essential background data for future studies of serum individual bile acids in intestinal and hepatic disease.
An Outline and Atlas of Gynaecological Cytodiagnosis
Authors: Tilde S. Kline
Journal: JAMA (1966)

<b>Clinical Endocrine Cytology</b>, by Jacoba C. de Neef, 321 pp, 205 illus, $12.50, New York: Hoeber Medical Division, Harper &amp; Row, Publishers, Inc., 1965. Two books on cytology have been published which should be of value to any clinician interested in gynecologic cytology. The<i>Atlas</i>is a well-written manual with superb plates. There is a good outline of normal gynecologic cytology. Approximately one third of the monograph is devoted to the effect of hormones on vaginal epithelial cells; concluding this section is the important and sometimes neglected limitation of cytologic hormonal evaluation: "The patterns one encounters in cytology practice... are usually not as distinct as those described." There is a beautifully illustrated chapter on cellular changes following irradiation. Abnormal and malignant gynecologic cytology is described too concisely, but many other texts are available on this subject. Included also are brief chapters on tumor cells in the blood, the cytology of
David Gavin Millar
Authors: S. Duncan
Journal: BMJ (2015)

After qualifying, David Gavin Millar joined the Peterculter Practice, working in a new health centre, the first in the north of Scotland. David fitted into the practice very easily and was highly respected and valued by colleagues and patients.

Roxburghe House, a purpose built hospice, opened within the practice area in 1977. David was actively involved from the outset as a hospital practitioner until 1992 when he joined …
SODIUM CITRATE IN INFANT FEEDING.
Authors: A. C. COTTON
Journal: JAMA (1906)

The infant deprived of the breast must, in relation to his feeding, be regarded as a pathologic problem. That this statement is axiomatic is shown by the fact that more earnest work has been bestowed on infant feeding during the past twenty years than on all other pediatric subjects combined. That the problem is still unsolved the high relative mortality and later morbidity of artificially fed infants bear constant witness. The six essentials of Cheadle, enunciated by that observer some time in the '80s, bear witness that the essential requirements of an artificial food for babies were broadly understood 20 years ago. Quoting from memory, they are briefly as follows: 1. Sterility. 2. Antiscorbutic property. 3. Quantity. 4. Some animal constituents. 5. Form suitable. 6. Constituency. Much has been learned since Cheadle by amassing clinical results and observations. Meanwhile the deductions from<i>a priori</i>reasoning have proven unsatisfactory for the
RANDOMISED TRIAL COMPARING TWO COMBINATION CHEMOTHERAPY REGIMENS (HEXA-CAF VS CHAP-5) IN ADVANCED OVARIAN CARCINOMA
Authors: J.P. Neijt, M.E.L. Van Der Burg, R. Vriesendorp, A.C.M. Van Lindert, M. Van Lent, W.W. Ten Bokkel Huinink, A.T.Van Oosterom, C.D. Kooyman, J.V.T.H. Hamerlynck, J.C.Van Houwelingen, H.M. Pinedo
Journal: The Lancet (1984)
The Naturalness of Dying-Reply
Authors: Jack D. McCue
Journal: JAMA (1995)

<h3>In Reply.</h3> —Drs Honig and Weiner succinctly summarize the concept that aging itself does not cause physical and intellectual decline. Presumably, these declines are the result of undiagnosed or undiagnosable disease. This belief, which was explored with insight and wit by Goodwin,<sup>1</sup>is no longer tenable unless one is willing to reject more than a decade of careful clinical and basic science research, much of which is referenced in my article. Despite the belief that a centenarian who remains entirely healthy should be as physically and intellectually functional as he or she was 50 or 80 years earlier, millennia of careful observations of the process of aging (and, at the risk of being too imprecise, common sense) indicate otherwise. Unfortunately, there are no persuasive data to contradict the observations that decline precedes a natural death and that death eventually comes to all, whether healthy or ill. If there were,
Hamartoma Syndromes, Exome Sequencing, and a Protean Puzzle
Authors: John M. Opitz, Lynn B. Jorde
Journal: New England Journal of Medicine (2011)

Gross malformations have been well known for centuries, even millennia. However, it was not until 1904 that Albrecht coined the concept of hamartoma. In 1934, the concept entered the field of developmental pathology generally in reference to tissue malformations. Hamartomata are localized overgrowths of a single tissue or combination of tissues, indigenous to the affected body part or organ, usually growing at the same rate as the normal components and causing little pain or functional impairment. They are a key finding in the Proteus syndrome, the cause of which has now been identified by Lindhurst et al.1 in this issue . . .
Expression of helper T cell master regulators in inflammatory dermatoses and primary cutaneous T-cell lymphomas: Diagnostic implications
Authors: Andy C. Hsi, Sena J. Lee, Ilana S. Rosman, Kenneth R. Carson, Amanda Kelley, Valerie Viele, Xiaofan Pang, Amy Musiek, András Schaffer
Journal: Journal of the American Academy of Dermatology (2014)
Shining a Light on the Brain
Authors: Tracy Hampton
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lost in Translation: Physicians' Struggle With Cost-Reduction Programs
Authors: Howard B. Beckman
Journal: Annals of Internal Medicine (2011)

Relationships between health plans and the medical profession are often strained, leading to the inability to create a shared vision for the health care redesign needed to more effectively care for our population. Because of their respective stakeholders, health plans and providers naturally differ in perspective. However, this article suggests that it is the inability of stakeholders to find a common language to effectively communicate interests, needs, and proposed interventions that often derails progress toward common goals. The business and health plan leaders' focus on cost-containment and cost-efficiency predictably results in physician defensiveness and disengagement. At the same time, physicians' limited focus on improving quality to only reducing underuse, which in the short term increases costs, does not acknowledge cost concerns of business leaders and health plan executives. However, as divergent as these emphases might seem, there is potential for common ground with effective language translation. Effective translation has been proposed through the Institute of Medicine's definition of quality as reducing overuse, misuse, and underuse. Creating a common language provides seemingly opposing groups an opportunity to explore a shared vision. Using the language of clinical appropriateness and reducing unnecessary variation has resulted in agreement on clinical quality improvement projects from which each group can return to its own organizations and translate back into its familiar “stakeholder” language.
Effect of Vagal and Sympathetic Stimulation and Ablation on Gastric Blood Flow
Authors: Edward T. Peter, Demetre M. Nicoloff, Arnold S. Leonard, Arnold I. Walder, Owen H. Wangensteen
Journal: JAMA (1963)

NEUROGENIC INFLUENCES on the stomach have promoted a great deal of discussion and investigation within recent years. Vagal influences upon gastric secretion have been observed and studied for a number of years. Hartzell,<sup>1</sup>in 1929, reported a reduction in gastric acidity following section of the vagus nerve. The classical work of Pavlov,<sup>2</sup>demonstrating cephalic influences on gastric secretion, are known to almost every student of gastric physiology. Sympathetic influences upon gastric secretion have similarly been studied by Gaultier<sup>3</sup>and others. Ablation of vagal influences upon gastric secretion has been used in designing operations for duodenal ulcer patients. Dragstedt<sup>4,5</sup>advocated vagotomy in the treatment of duodenal ulcer patients. More recently, vagotomy has been combined with other procedures in the surgical management of peptic ulcer disease. It is well known that vagal stimulation by direct electrical stimulation or by insulin hypoglycemia will produce gastric hypersecretion. This effect may