tbuckley/cabot-search huggingface dataset:
Consciousness without corticocentrism: Beating an evolutionary path
Authors: David B. Edelman
Journal: Behavioral and Brain Sciences (2007)

Merker's approach allows the formulation of an evolutionary view of consciousness that abandons a dependence on structural homology – in this case, the presence of a cerebral cortex – in favor of functional concordance. In contrast to Merker, though, I maintain that the emergence of complex, dynamic interactions, such as those which occur between thalamus and cortex, was central to the appearance of consciousness.
The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial
Authors: David G. Oscier, Matthew J. J. Rose-Zerilli, Nils Winkelmann, David Gonzalez de Castro, Belen Gomez, Jade Forster, Helen Parker, Anton Parker, Anne Gardiner, Andrew Collins, Monica Else, Nicholas C. P. Cross, Daniel Catovsky, Jonathan C. Strefford
Journal: Blood (2012)
Effect of marathon training on the plasma lactate response to submaximal exercise in middle-aged men.
Authors: A G Rumley, R Taylor, S Grant, A R Pettigrew, I Findlay, H Dargie
Journal: British Journal of Sports Medicine (1988)

Twenty-one previously sedentary male volunteers (aged 35-50 years) undertook a defined marathon training programme lasting 30 weeks. At weeks 0 (T1), 15 (T2) and 30 (T3) they underwent measurement of maximal oxygen uptake (VO2 max), submaximal VO2 and submaximal plasma lactate concentration during cycle ergometry. No exercise was taken for 24-48 hours prior to testing. During training aerobic power increased significantly (p less than 0.001) from an initial VO2 max at T1 of 33.9 +/- 6 (mean +/- sd) ml.kg-1min-1 to 39 +/- 5.6 ml.kg-1min-1 at T2 but the T3 value of 39.2 +/- 5.2 ml.kg-1min-1 was not significantly different from that at T2. Plasma lactate concentration of 4 mmol.l-1 (OBLAw) occurred at a significantly (P less than 0.05) higher workload (155 +/- 28 w) at T2 compared with T1 (132 +/- 30 w) but the T3 figure was 137 +/- 34 w. OBLA VO2 at T1 was 2.04 +/- 0.42 l.min-1, at T2 was 2.24 +/- 0.04 l.min-1 but at T3 was 2.03 +/- 0.30 l.min-1 (T1:T2 P less than 0.05, T1:T3 NS). OBLA % VO2 max at T1 was 75 +/- 12%, at T2 was 73 +/- 11% but at T3 was 62 +/- 10% (T1:T2 NS, T1:T3 P less than 0.01).
Subclavian Catheterization Precaution
Authors: John W. Moore
Journal: JAMA (1971)

<h3>To the Editor.—</h3> In a letter to the Editor (<b>217</b>:78, 1971) Goldman et al cautioned against the use of subclavian vein puncture because of the reported occurrence of subclavian artery laceration. A precaution I find helpful in performing this useful procedure is to bend the needle about 15° in the direction of the open surface of the bevel. This allows the needle point to be introduced more nearly parallel to the course of the vein and lessens the likelihood of a deep thrust into the vicinity of the artery. The thin-walled needle is not difficult to bend with the gloved hands. Avoidance of the use of an instrument prevents crimping the needle; the gentle curve which results does not impede passage of the catheter.
Another VCP interactor: NF is enough
Authors: Conrad C. Weihl
Journal: Journal of Clinical Investigation (2011)

Inclusion body myopathy with Paget disease of the bone and frontotemporal dementia (IBMPFD) is a multisystem degenerative disorder caused by mutations in the valosin-containing protein (VCP) gene. How missense mutations in this abundant, ubiquitously expressed, multifunctional protein lead to the degeneration of disparate tissues is unclear. VCP participates in diverse cellular functions by associating with an expanding collection of substrates and cofactors that dictate its functionality. In this issue of the JCI, Wang and colleagues have further expanded the VCP interactome by identifying neurofibromin-1 (NF1) as a novel VCP interactor in the CNS. IBMPFD-associated mutations disrupt binding of VCP to NF1, resulting in reduced synaptogenesis. Thus, aberrant interactions between VCP and NF1 may explain the dementia phenotype and cognitive delay observed in patients with IBMPFD and neurofibromatosis type 1.
Abstract IA13: Recurrent SPOP mutations define a distinct molecular subclass of prostate cancer
Authors: Christopher E. Barbieri, Sylvan C. Baca, Michael S. Lawrence, Gad Getz, Mark A. Rubin, Levi A. Garraway
Journal: Cancer Research (2012)

Abstract Prostate cancer is a clinically heterogeneous disease with marked variability in outcomes. To identify somatic mutations that may drive prostate cancer and aid in molecular characterization, we sequenced the exomes of 112 tumor/normal pairs obtained from men with localized disease. SPOP (Speckled Type POZ) was the most frequently mutated gene, with mutations involving the SPOP substrate binding cleft in 6-15% of tumors from multiple independent cohorts. SPOP-mutant prostate cancers lacked ETS rearrangements and exhibited a distinct pattern of genomic alterations. Thus, SPOP mutations may define a new molecular subtype of prostate cancer. Citation Format: Christopher E. Barbieri, Sylvan C. Baca, Michael S. Lawrence, Gad Getz, Mark A. Rubin, Levi A. Garraway, On the behalf of the Broad Institute and Weill Cornell Medical College Prostate Cancer Sequencing Group. Recurrent SPOP mutations define a distinct molecular subclass of prostate cancer [abstract]. In: Proceedings of the AACR Special Conference on Advances in Prostate Cancer Research; 2012 Feb 6-9; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2012;72(4 Suppl):Abstract nr IA13.
Treatment of Some Bullous Eruptions with Aureomycin and Chloramphenicol
Authors: F. R. Bettley, E. A. Fairburn
Journal: BMJ (1951)

y-RESORCYLATE IN RHEUMATIC FEVER MEDICALJOURNAL cloudy swelling of the tubules of the kidney; this change was not so marked, however, as with corresponding doses of salicylate.Absorption and Excretion.-Theabsorption and excretion of this substance are rapid; after a subcutaneous 10-mg.dose in the rat the substance appears in the urine in one hour and is nearly all eliminated three hours after injection.After administration by mouth the quantity in the urine is smaller than after a similar dose given subcutaneously, in- dicating that the absorption is not so complete by the oral route.Reduction of Formalin-induced Swellings.-If4% formalin is injected into the pad of the foot of a mouse a swelling of the lower part of the leg results which is maximal at the end of seven days.If the animal is treated with A.C.T.H., 1 mg.equivalents twice daily, from the time of the injection this swelling is considerably reduced.Treatment with y- resorcylate, 5 mg.daily in the diet or 0.5 mg.daily by sub- cutaneous injection, produced a reduction of swelling of the same order as that found with the A.C.T.H.Similar doses of sodium salicylate do not produce an appreciable effect.
AN INTERESTING CASE [MORPHIA HABIT].Read before the Shelby County Medical Society at Shelbyville, Ind., March 12, 1894.
Authors: H. O. PANTZER
Journal: JAMA (1894)

An irritable stomach from stenosis of the esophagus is treated long time for cancer of the stomach, when the morphia habit is formed. Exploratory laparotomy leads to a correct diagnosis. Cure by bougies and irrigation of the stomach. The morphia habit is cured by the resuscitation of the moral powers. Discussion of the essentials underlying the cure from vice of habit of any kind. Subsequent development of cancer in the right ovary. Cure by celio-salpiugo-oöphoreetomia duplex. Mrs. M. L., American, aged 42 years, is married and the mother of four children. I was called to see her in consultation with her family physician, Dr. R. F. Bigger, in April of 1892. Then she had been an invalid of four years, being confined to bed continuously of late. The disease began with an irritable stomach and indigestion. She frequently vomited after eating, and retching at times was quite persistent. At times,
MYOCARDIAL SYMPATHETIC NERVE ACTIVITY IS ASSOCIATED WITH LEFT VENTRICULAR HYPERTROPHY AND CLINICAL OUTCOME IN HEART FAILURE PATIENTS WITH PRESERVED EJECTION FRACTION
Authors: Yoshikazu Yazaki, Seki Toshimasa, Yukiko Hayashi, Minoru Hongo, Ikeda Uichi
Journal: Journal of the American College of Cardiology (2013)
Reduce repayment rates to 0.5%
Authors: A. N. Bamji
Journal: BMJ (2012)

Monitor anticipated the Peterborough and Stamford debacle.1 Why did Monitor not raise similar concerns in south east London before the financially disastrous merger of three hospitals?1 Hospital consultants warned of the problem on the basis of an analysis by the finance directors, which stated unequivocally that private finance initiative (PFI) payments for the merged trust could …
TRADITION IN DERMATOLOGY.*
Authors: H. MacCormac
Journal: British Journal of Dermatology (1924)

Journal Article TRADITION IN DERMATOLOGY. Get access H. MacCormac, C.B.E., M.D., F.R.C.P. H. MacCormac, C.B.E., M.D., F.R.C.P. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 36, Issue 6, 1 June 1924, Pages 235–244, https://doi.org/10.1111/j.1365-2133.1924.tb09189.x Published: 01 June 1924
Discussion of risk pervades doctor-patient communication
Authors: A. F Smith
Journal: BMJ (2002)

EDITOR—Edwards et al neatly summarised the state of current knowledge on communicating risk.1 I have three further points to add.

Firstly, readers may be interested in the risk ladder we developed to display the risks associated with anaesthesia in comparison with some everyday risks (figure). 2 3



Risk ladders for everyday and clinical risks. Reproduced with permission of Blackwell Scientific



Secondly, I think that the authors either have chosen not to address or been unaware that communication about risk and safety takes place throughout a consultation and not simply when the …
Abstract 2323: Iron chelator contributes to anti-angiogenic therapy via selective induction of VEGF-A
Authors: Toshiaki Ohara, Kazuhiro Noma, Seishi Nishitani, Shinichiro Watanabe, Yasuko Tomono, Yuuri Hashimoto, Hiroshi Tazawa, Toshiyoshi Fujiwara
Journal: Cancer Research (2012)

Abstract [Introduction] Iron is essential for cancer to survive. Cancer cell is suppressed to proliferate under the iron depletion condition using iron chelator. However, only iron depletion can't suppress tumor growth completely. The reason is that cancer cell has abilities to escape the severe environment. These abilities are known as angiogenesis, migration, etc. Thus, to inhibit not only cancer cell proliferation but also these abilities are important for anti-cancer therapy. Bevacizumab, an antibody against vascular endothelial growth factor, is the first clinical anti-angiogenic drug. It's used for many kinds of cancer patients and revealed clinical benefit. According to spread widely in use, the resistance of Bevacizumab has been recognized. Recently, patients in resistance of Bevacizumab were reported to be high concentration of PIGF, VEGF-C and VEGF-D. On the other hand, we have demonstrated a synergistic therapeutic effect of iron depletion on anti-angiogenic therapy for human cancer in this meeting. In vitro study, iron chelator was used to simulate the iron depletion condition. Our result showed that iron depletion has anti-proliferative effect and induction of VEGF-A. Therefore, Bevacizumab revealed a synergistic therapeutic effect in iron depletion condition. In this study, we hypothesized that iron chelation therapy has anti-proliferative effect and induction of only VEGF-A(not PIGF, VEGF-C and VEGF-D). [Matherials and Methods] A549, H1299 NSCLC cell lines were used. Iron chelator deferasirox and deferoxamine were prepared to simulate iron depletion condition. Cell viability was determined by WST-1 assay. To determine induction of iron chelator, PIGF, VEGF-A, C, D ELISA assays were performed. In vivo Bevacizumab administration study, we used A549 subcutaneous tumor xenograft mice(n=5/group). Deferasirox(50mg/kg) was administrated orally 5days in a week. Bevaicuzmab(5 mg/kg) was administrated twice a week intravenously. [Results] Iron chelator suppressed cancer cell proliferation and induced only VEGF-A(not PIGF, VEGF-C and VEGF-D). VEGF-A was induced by iron chelator in dose dependent manner. Deferasirox revealed synergistic anti-tumor effect with Bevacizumab in vivo study. [Conclusion] Iron chelator contributes to anti-angiogenic therapy via selectively inducing VEGF-A. Iron chelator can be a new therapeutic strategy of Bevacizumab combination therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2323. doi:1538-7445.AM2012-2323
Abstract 3317: Study of response in neural stem cells after cerebral irradiation
Authors: Doo-Sik Kong, Kyung Min Joo, Do-Hyun Nam
Journal: Cancer Research (2010)

Abstract Objective: Ionizing irradiation causes cell death but also birth and migration of new neurons within sites of cerebral damage. The cellular environment that induces neuronal regeneration and migration after irradiation has not been defined yet. The aim of this study was to evaluate the neuronal response after irradiation injury induced by gamma knife radiosurgery. Methods: We used a model of long-distance migration of newly transplanted neural stem cells from the subependymal zone on the other hemisphere to that on the ipsilateral side after irradiation using gamma knife radiosurgery for the purpose of defining the cellular cues that induce neuronal regeneration after CNS injury. Results: In vitro and in vivo studies showed that irradiation induced neurogenesis from transplanted GFP-tagged neural stem cells and migration of newly born neurons into a unique neurovascular niche. Within this neurovascular niche, newly born, immature neurons were closely associated with the remodeling vasculature. The relationship between neurogenesis and angiogenesis is causally linked through vascular production of CD31 and VEGF receptor-2. Conclusions: These experiments defined a novel brain environment for neuronal regeneration after irradiation using gamma knife radiosurgery and identified molecular mechanisms that are shared between angiogenesis and neurogenesis during functional recovery from brain injury. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3317.
Quantifying the Effects of Rare Variants in Pedigrees
Authors: Eric M. Morrow
Journal: JAMA Psychiatry (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Managed Care Arrives in Latin America
Authors: Eliseo J. Pérez-Stable
Journal: New England Journal of Medicine (1999)

In the 19th century, European imperialists obtained control of resources and markets in developing countries to facilitate economic expansion. In 1898, the United States joined the ranks of the imperialists with its efficient victory in the Spanish–American War. A century later, the world economy is characterized by global markets and universal access to information. Throughout Latin America, large international corporations are expanding their presence in telecommunications, transportation, energy, and other areas. Now health care can be added to the list. In this issue of the Journal, Stocker and colleagues1 provide a well-researched analysis of a relatively little known phenomenon — . . .
Treatment of Streptococcal Pharyngitis Revisited
Authors: James W. Bass
Journal: JAMA (1986)

Penicillin has remained the drug of choice for treatment of patients with streptococcal pharyngitis for the past four decades. From the early 1950s into the 1970s, a single injection of intramuscular penicillin G benzathine, alone or in combination with penicillin G procaine, was the preferred treatment. Because this regimen consistently produced the highest cure rate and because compliance was assured, it evolved as the gold standard with which other treatment regimens were compared. In the late 1960s and the 1970s, studies showed that in private practice settings with counseling as to the need to take oral penicillin for a full ten days to prevent rheumatic fever, good compliance with results equal to intramuscular penicillin G benzathine could be achieved. By the early 1980s, oral treatment was preferred by most primary physicians in the United States. Oral penicillin V in a dosage of 250 mg, twice daily for ten days, affords optimal treatment for children. In areas where rheumatic fever is still prevalent, particularly in poor and crowded inner-city populations where medical care is episodic, follow-up may be lacking, and compliance in taking oral penicillin cannot be relied on, treatment with intramuscular penicillin G benzathine remains preferred. Studies now confirm that early treatment of streptococcal pharyngitis can reduce the duration of symptoms to less than 24 hours in most cases, decrease the incidence of suppurative complications, limit spread of the disease in the family and community, and permit earlier return of the child to school. Recently developed tests that permit rapid, laboratory-confirmed diagnosis of streptococcal pharyngitis directly on the throat swab at the initial clinic visit may soon guide early treatment with these inherent benefits.
Antigen‐Specific Down‐Regulation of Bronchial Reactivity in Rats Sensitized Daily without Adjuvant
Authors: S. Ahlstedt, K. Alving, E. Olaisson
Journal: Allergy (1986)

Daily sensitization with ovalbumin (OA) and dog serum albumin (DSA) without adjuvant was performed in rats for 2‐week periods. When the antigen was administered subcutaneously (s.c.), antibody responses were induced, as assessed in serum and bronchial lavage, and strong increases in transpulmonary pressure (TPP) after intravenous (i.v.) challenge with antigen. Sensitization without adjuvant with antigen as aerosol for similar periods also evoked pronounced antibody formation, although only weak increases of TPP were seen after challenge. Animals sensitized s.c. with OA and simultaneously exposed to OA as aerosol exhibited suppression of the TPP increase after challenge, whereas the antibody responses were not affected to any great extent. In contrast, the increase of TPP after challenge in animals similarly sensitized s.c. with DSA were not suppressed by OA given simultaneously as aerosol or vice versa.
Urticaria pigmentosa: clinical picture and response to oral disodium cromoglycate
Authors: BEATE M. CZARNETZKI, HEIDRUN BEHRENDT
Journal: British Journal of Dermatology (1981)

Journal Article Urticaria pigmentosa: clinical picture and response to oral disodium cromoglycate Get access BEATE M. CZARNETZKI, BEATE M. CZARNETZKI Universitäts‐Hautklinik, von‐Esmarchstr. 56, 4400 Münster Search for other works by this author on: Oxford Academic Google Scholar HEIDRUN BEHRENDT HEIDRUN BEHRENDT Med. Institut für Umweltforschung, Gurlitistr. 53, 4000 Düsseldorf, F.R.G. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 105, Issue 5, 1 November 1981, Pages 563–567, https://doi.org/10.1111/j.1365-2133.1981.tb00800.x Published: 01 November 1981 Article history Accepted: 17 January 1981 Published: 01 November 1981
Superoxide dismutase and myeloperoxidase activity in polymorphonuclear leukocytes, and serum ceruloplasmin and copper levels, in psoriasis
Authors: P. DOǦAN, Ü. SOYUER, G. TANRIKULU
Journal: British Journal of Dermatology (2006)

The levels of superoxide dismutase (SOD) and myeloperoxidase (MPO) in polymorphonuclear leukocytes (PMN), and serum ceruloplasmin activity and copper content, were measured in 60 patients with psoriasis and 33 healthy controls. There were no significant differences in the activity of MPO between the patients and the controls. However, SOD activity in PMN was significantly lower in the patients than in the controls. Serum ceruloplasmin activity and copper levels were significantly higher in the psoriatics than in the controls.
Electroretinographic and Psychophysical Findings during Early and Late Stages of Human Immunodeficiency Virus Infection and Cytomegalovirus Retinitis
Authors: Paul A. Latkany, Karen Holopigian, Monica Lorenzo-Latkany, William Seiple
Journal: Ophthalmology (1997)

<b>Purpose:</b> The authors examined electrophysiologic and psychophysical measures of retinal function in patients infected with human immunodeficiency virus (HIV) at different stages of infection, including patients with cytomegalovirus retinitis (CMVR). <b>Methods:</b> All patients had complete ophthalmologic examinations. Rod-mediated psychophysical thresholds were measured using a modified two-color dark-adapted perimetry technique. Rod-dominated full field flash electroretinograms (ERGs) were obtained as a function of flash intensity, followed by cone-dominated ERGs. The 26 patients infected with HIV (26 eyes) were categorized into three groups. Six patients were infected with HIV but had not progressed to acquired immunodeficiency syndrome (AIDS), and 14 had AIDS. Six patients had CMVR with less than 10% of the retina involved. The data were compared with results from age-similar control subjects. <b>Results:</b> Psychophysical thresholds as a function of retinal eccentricity were elevated for each of the three stages of HIV infection. The group of patients with CMVR had the greatest amount of threshold elevation and threshold elevation increased with retinal eccentricity. In addition, all three patient groups had abnormal electroretinographic findings. Patients with CMVR were affected more severely on all measures than were the other HIV-infected groups. <b>Conclusions:</b> Results reveal that a diffuse functional retinal pathology exists in eyes with the funduscopic appearance of localized peripheral CMVR. Additionally, patients infected with HIV, including those without cotton wool spots, may have abnormal retinal function.
Asthma: analysis of sudden deaths and ventilatory arrests in hospital.
Authors: M R Hetzel, T J Clark, M A Branthwaite
Journal: BMJ (1977)

The incidence of episodes of unexpected ventilatory arrest, some of which led to sudden death, was studied in 1169 consecutive hospital admissions for asthma. Of the most acute cases, 458 were initially managed in a special care unit where only one ventilatory arrest occurred. A further nine cases of arrest, three of which proved fatal, happened on general wards. Accepted clinical criteria of a severe attack were not present in those episodes occurring outside the unit, which were apparently mild attacks. The risk of sudden death could not be related to the severity of the attack but it did correlate with the presence of excessive diurnal variation in peak expiratory flow rate (PEFR). Special treatment of patients with this sign might reduce mortality.