tbuckley/cabot-search huggingface dataset:
Analgesic Nephropathy: Clinical Syndrome and Prognosis
Authors: R. M. Murray, D. H. Lawson, A. L. Linton
Journal: BMJ (1971)

Over a five-year period 86 patients presented to a renal unit with a history of prolonged analgesic abuse and no other obvious cause of renal damage. Anaemia and peptic ulceration were common, and neurological states suggestive of chronic analgesic intoxication occurred in 22 patients. Thirty-two patients died during follow-up, but the prognosis was much better in patients who ceased abuse of compound analgesics, and improvement could occur even in advanced renal failure. While 84 patients had taken mixtures containing both aspirin and phenacetin, papillary necrosis was also found in two patients who had abused only aspirin, and when phenacetin was withdrawn from several leading compound analgesics, renal function continued to deteriorate in patients ingesting those preparations.
Coronary Arteriosclerosis Induced in Young Dogs by Prolonged Intra-aortic Infusions of Serotonin
Authors: PAOLO ROSSI, MAUDE STEVENSON, PARVIZ KHAKSAR, SAMUEL BELLET
Journal: Circulation Research (1961)

The cardiac effects of serotonin were studied in 20 young mongrel dogs. Serotonin was slowly infused through a catheter inserted into the left carotid artery with the tip of the catheter located 1 or 2 cm. above the coronary orifices. The doses for different groups of dogs were 10, 5, 2, and 1 mg. in 500 cc. of normal saline, three to six times each week. The period of infusion lasted one to six weeks. A group of four dogs acted as controls. In dogs treated for more than two weeks with doses of 10 to 5 mg., and in those treated for more than four weeks with doses of 2 mg., the following pathological findings were observed: (a) fibrotic thickening of mitral, aortic, and tricuspid valves in this order of frequency; (b) myocardial hemorrhages partially organized ; (c) focal ischemic necrosis of myocardium with or without round cell infiltrations; (d) intimal thickening of small coronary arteries either in the form of cushions bulging into the lumen or extensive subendothelial thickening with asymmetrical reduction of the lumen. The intima of these arteries showed either an acellular homogeneous substance or a fibroblastic proliferation and fibroelastic hyperplasia. These findings were considered to be related to a direct action of serotonin which plays some role in the connective tissue function.
Abstract 1407: The influence of EWS-FLI1 on the Rho/Actin/MRTF circuit in Ewing sarcoma
Authors: Anna M. Katschnig, Raphaela Schwentner, Stephan Niedan, Maximilian O. Kauer, Elizabeth R. Lawlor, Dave N.T. Aryee, Heinrich Kovar
Journal: Cancer Research (2014)

Abstract Ewing sarcoma (ES) is the second most common bone tumor in children and adolescents. The disease is characterized by the expression of the aberrant transcription factor EWS-FLI1, which is a fusion gene product originating from the chromosomal translocation t(11;22)(q24;q12). Despite good treatment outcomes for patients with localized ES, about 25% of patients already harbor metastatic disease upon presentation and are prevalently faced with poor overall survival. The metastatic cascade is a complex process. Remodeling of the actin cytoskeleton is the first step for a cell in order to acquire a migratory phenotype. The major regulator of the actin cytoskeleton is the Rho family of GTPases, which upon G-protein coupled receptor (GPCR) signaling gets activated and promotes the polymerization of monomeric G-actin into stress fibers. Concurrently G-actin releases the myocardin-related transcription factor family (MRTF) of transcriptional coactivators. MRTFs translocate into the nucleus where they, together with the transcription factor serum response factor (SRF), bind to serum response elements (SRE) in the promoter of genes involved in cell adhesion, migration and motility. However, the ternary complex factor (TCF) family, a class of transcriptional coactivators activated through Ras signaling, can compete with MRTFs for SRF complexing and binds to ets-motifs on SRE. The ets-transcription factor EWS-FLI1 has been shown to substitute for TCFs, potentially interfering with SRF target gene expression. We therefore hypothesize that EWS-FLI1 interferes with GPCR downstream signaling by competition with MRTFs. By gene expression profiling, we show that several putative MRTF target genes are repressed in the presence of EWS-FLI1 in ES cell lines and are strongly induced upon EWS-FLI1 knockdown. Using the MRTFA target gene transgelin (TAGLN) as an example, we show that knockdown of MRTFA can only reduce its serum inducibility in the absence but not in the presence of EWS-FLI1 supporting our hypothesis of EWS-FLI1 perturbing GPCR signaling in ES. With this study we want to elucidate the role of EWS-FLI1 in the regulation of early steps of the metastatic process in ES. Supported by the Liddy Shriver Sarcoma Initiative. Citation Format: Anna M. Katschnig, Raphaela Schwentner, Stephan Niedan, Maximilian O. Kauer, Elizabeth R. Lawlor, Dave N.T. Aryee, Heinrich Kovar. The influence of EWS-FLI1 on the Rho/Actin/MRTF circuit in Ewing sarcoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1407. doi:10.1158/1538-7445.AM2014-1407
Tumor necrosis factor alpha cooperates with interleukin 3 in the recruitment of a primitive subset of human CD34+ progenitors.
Authors: C Caux, I Durand, I Moreau, V Duvert, S Saeland, J Banchereau
Journal: The Journal of Experimental Medicine (1993)

We have recently demonstrated that tumor necrosis factor alpha (TNF-alpha) potentiates interleukin 3 (IL-3) and granulocyte/macrophage colony-stimulating factor-induced growth of CD34+ hematopoietic progenitor cells (HPC), and favors the generation of dendritic/Langerhans cells. The stimulatory effect of TNF-alpha was detailed in the present study. Thus, CD34+ HPC entering in cycle (S/G2M) after a 48-h pulse with IL-3 expressed the transferrin receptor (TfR), and fluorescence-activated cell sorter-separated TfR+ HPC, but not TfR-HPC, showed a high proliferative response to IL-3. In contrast, TfR-HPC were found to undergo strong proliferation in response to IL-3 + TNF-alpha. Limiting dilution experiments indicated that TNF-alpha increased both the frequency and the average size of clones generated from TfR-HPC as a result of the development of a higher number of large clones. In contrast, TNF-alpha did not enhance the IL-3-dependent proliferation of TfR+ HPC. Preculturing CD34+ HPC for 48 h with TNF-alpha enhanced the subsequent generation of IL-3-dependent colony-forming units. Precultures with TNF-alpha or cultures with suboptimal doses of TNF-alpha allowed the recruitment of cells with both granulocytic and monocytic differentiation potential. Taken together, our results indicate that TNF-alpha recruits a subpopulation of CD34+ HPC hyposensitive to IL-3, with high proliferative capacity and some features of multipotential progenitors, that are likely to be more primitive than those responding to IL-3 alone.
Hypersensitivity pneumonitis associated with temozolomide
Authors: L. Guilleminault, P. Carré, P. Diot
Journal: European Respiratory Journal (2009)

<h3>Objective</h3> This study aimed to test fecal calprotectin (FC) as a screening tool to identify inflammatory bowel disease (IBD) among patients with juvenile idiopathic arthritis (JIA). <h3>Methods</h3> FC level &lt; 100 g/kg was considered normal. Patients with 2 consecutive FC dosage ≥ 100 g/kg underwent endoscopic evaluation. <h3>Results</h3> There were 113 patients with JIA enrolled. FC was raised in 7 patients out of 113. All patients had IBD. In 3/7 patients, high FC levels were the only sign consistent with IBD. <h3>Conclusion</h3> FC is a useful, economical, and noninvasive diagnostic tool to identify JIA patients with underlying IBD.
Mechanism and Management of Headache
Authors: Rodney D. Bell
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes20 April 1999Mechanism and Management of HeadacheRodney D. Bell, MDRodney D. Bell, MDThomas Jefferson University, Philadelphia, Pennsylvania. (Bell)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-8-199904200-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail 6th edition. Lance JW, Goadsby PJ; eds. 317 pages. Oxford: Butterworth-Heinemann; 1998. $95.00. ISBN 0750637285. Order phone 800-366-2665.Field of medicine: Neurology, internal medicine, and primary care.Format:Hardcover book.Audience: Neurologists, general internists, and primary care providers.Purpose: To present the newest thinking on the pathophysiology of headache and to review an integrated approach to pharmacologic treatment.Content: The initial chapter on the history of headache places in perspective how long this problem has been with us. Another early chapter outlines the International Headache Society's classification for headache disorders, cranial neuralgias, and facial pain. The remainder of the book ... Author, Article, and Disclosure InformationAffiliations: Thomas Jefferson University, Philadelphia, Pennsylvania. (Bell) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProgression in migraine: Role of mast cells and pro-inflammatory and anti-inflammatory cytokines 20 April 1999Volume 130, Issue 8Page: 703-704KeywordsCluster headacheHeadachesMigraineNeurologySoftware tools ePublished: 15 August 2000 Issue Published: 20 April 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Evidence for cholinergically mediated vasodilation at the beginning of isometric exercise in humans.
Authors: J S Sanders, A L Mark, D W Ferguson
Journal: Circulation (1989)

Vasodilation occurs in the nonexercising forearm at the beginning of isometric handgrip despite activation of sympathetic vasoconstrictor reflexes. The mechanism of this response remains unclear. In 33 normal humans, age 24 +/- 1 years (mean +/- SEM), we measured mean arterial pressure, heart rate, and forearm blood flow (plethysmography) in the nonexercising arm during sustained contralateral isometric handgrip at 30% maximal voluntary contraction. Sympathetic nerve activity to calf muscles (microneurography) was also measured in 15 subjects. Handgrip resulted in increases in arterial pressure from 86 +/- 2 to 97 +/- 3 mm Hg (p less than 0.05). Despite increases in nerve activity to calf muscles from 229 +/- 43 to 337 +/- 66 units (p less than 0.005), which would be expected to produce forearm vasoconstriction, forearm vascular resistance in the contralateral resting arm decreased from 20 +/- 3 to 18 +/- 2 units (p less than 0.05). To determine the mechanism of this vasodilatory influence, additional studies were performed with regional autonomic blockade with intra-arterial administration of atropine (0.8 mg, 10 subjects) or propranolol (2.0 mg, eight subjects) into the nonexercising forearm before contraction. Propranolol and vehicle had no effect on forearm vascular responses in the resting arm during SHG in the other arm. In contrast, atropine blocked the vasodilatory response in the resting arm during contraction (delta forearm vascular resistance during contraction, control = -2.1 +/- 0.6 units; postatropine = +0.2 +/- 0.9 units, p less than 0.05). Atropine did not attenuate the vasodilator response to isoproterenol or the vasoconstrictor response to norepinephrine. We conclude 1) a dissociation exists between sympathetic neural and forearm vascular responses to isometric exercise; 2) the vasodilatory response in the nonexercising forearm is not due to sympathetic withdrawal or beta 2-adrenergic-mediated vasodilation; and 3) this response is mediated primarily by cholinergic mechanisms. These studies provide the first direct evidence for active, cholinergically mediated vasodilation during exercise in humans.
Adenosine induced chest pain - a comparison between intracoronary bolus injection and steady state infusion
Authors: B. Lagerqvist, C. Sylven, E. Theodorsen, L. Kaijser, G. Helmius, A. Waldenstrom
Journal: Cardiovascular Research (1992)

Journal Article Adenosine induced chest pain – a comparison between intracoronary bolus injection and steady state infusion Get access Bo Lagerqvist, Bo Lagerqvist Correspondence to Dr Lagerqvist. Search for other works by this author on: Oxford Academic PubMed Google Scholar Christer Sylvén, Christer Sylvén Search for other works by this author on: Oxford Academic PubMed Google Scholar Elvar Theodorsen, Elvar Theodorsen Search for other works by this author on: Oxford Academic PubMed Google Scholar Lennart Kaijser, Lennart Kaijser Search for other works by this author on: Oxford Academic PubMed Google Scholar Gunnar Helmius, Gunnar Helmius Search for other works by this author on: Oxford Academic PubMed Google Scholar Anders Waldenström Anders Waldenström Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 8, August 1992, Pages 810–814, https://doi.org/10.1093/cvr/26.8.810 Published: 01 August 1992 Article history Received: 13 May 1991 Accepted: 03 March 1992 Published: 01 August 1992
Interleukin-8 Induces Lymphocyte Chemotaxis into the Pleural Space
Authors: ELISABETTA PACE, MARK GJOMARKAJ, MARIO MELIS, MIRELLA PROFITA, MARIO SPATAFORA, ANTONIO M. VIGNOLA, GIOVANNI BONSIGNORE, CHRISTOPHER H. MODY
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

The pleural space is a potential compartment between the lung and chest wall that becomes filled with fluid and inflammatory cells in a number of respiratory diseases. In an attempt to understand one aspect of the inflammatory process in the pleural space, we compared the responses in three different diseases (congestive heart failure [CHF], tuberculosis [TB], and cancer). Large concentrations of interleukin-8 (IL-8) were detected in cancer and TB effusions, but not in CHF. Surprisingly, the concentration of IL-8 correlated best with lymphocyte recruitment and not with neutrophil recruitment. Pleural fluid from cancer and TB patients was chemotactic for lymphocytes, and this activity was partly blocked by an anti-IL-8 antibody in cancer and completely blocked in TB. To determine whether there was the potential for a chemotactic gradient into the pleural space, pleural effusion cells were analyzed for the expression of IL-8. Cells in the effusions of cancer patients expressed IL-8, whereas IL-8 could not be detected from the cells of TB and CHF effusions. To explore the possible role of pleural macrophages in the regulation of IL-8, pleural effusion cells were treated with culture supernatants from stimulated pleural macrophages. Stimulated pleural macrophages were able to induce expression of messenger RNA (mRNA) for IL-8 and IL-8 protein production, and this activity was abrogated by blocking tumor necrosis factor- α . These findings suggest that soluble IL-8 is an important factor for the recruitment of lymphocytes into the pleural space, and that this cytokine is produced by both pleural structural and cancer cells after their activation by macrophage-derived, cytokine-mediated signals.
Prenatal and Postpartum Depression in Fathers and Mothers
Authors: Brett D. Thombs
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epicutaneous natural rubber latex sensitization induces localized Th2-dominate dermatitis and strong IgE response
Authors: Harri Tapio Alenius, Maili Lehto, Iman Amghaiab, Marja-Leena Majuri, Guoying Wang, Henrik Wolff, Kristiina Turjanmaa, Antti Lauerma, Timo Reunala, Timo Palosuo
Journal: Journal of Allergy and Clinical Immunology (2002)
Decreased Production of Antimicrobial Peptides in Chronic Rhinosinusitis Associated with Age and Elevated Soluble gp130
Authors: Sun Hye Lee, Seong Ho Cho, Kathryn E. Hulse, James Norton, Jason Siebert, David Conley, Rakesh Chandra, Anju Peters, Robert Kern, Leslie C. Grammer, Robert P. Schleimer
Journal: Journal of Allergy and Clinical Immunology (2013)
Growth-hormone deficiency in iatrogenic hypothyroidism.
Authors: R Wilkinson, M Anderson, G A Smart
Journal: BMJ (1972)

Utiger et al. (1962) found impairment of growth hormone response to insulin-induced hypoglycaemia in two out of five patients with hypothyroidism, and they and Iwatsubo et al., Root et al., and Braurman and Corvilain showed that the abnormality may be corrected by treating the hypothyroidism (Harrison et al., 1968).Harrison and his colleagues showed that growth hormone output is normal in treated endemic cretins.
Infectious Diseases: Epidemiology and Clinical Practice
Authors: Jerry Smilack
Journal: JAMA (1975)

Several texts devoted to the subject of infectious diseases have appeared in recent years. The second edition of Dr. Christie's book, in addition to its other merits, certainly excels in literary style. Writing of the near-disappearance of diphtheria he declared: "though fallen from its high estate, it may loiter in epidemiological sidewalks, ready to attack those who pass through..."; introducing varicella: "It is not clear how the chicken got into the chickenpox." Christie possesses a talent unique to medical writing, and the reader is the beneficiary. In this revision Christie has capably incorporated developments in such topics as serum hepatitis and infectious mononucleosis that have arisen since his original work of five years ago. He abandons tradition in the organization of the book itself by devoting all his attention to some 30 diseases with which he has had vast experience. As the title of the book indicates, the epidemiology of
TCT-210 Clinical Outcomes Following Resolute Zotarolimus-eluting Stent Implantation in Diabetic versus Non-Diabetic Patients Suitable for Percutaneous Coronary Revascularization: Insights From a Multicenter Italian Registry
Authors: Alfonso Ielasi, Azeem Latib, Francesco Burzotta, Francesco Summaria, Maria De Vita, Angelo Anzuini, Claudio Larosa, Francesco Della Rovere, Saverio Lanzone, alessandro manzoli, Francesca Giovannelli, Antonio Colombo
Journal: Journal of the American College of Cardiology (2013)
Aromatase Inhibitors in Breast Cancer
Authors: Ian E. Smith, Mitch Dowsett
Journal: New England Journal of Medicine (2003)

Until recently, tamoxifen, a nonsteroidal antiestrogen, was the mainstay of endocrine treatment of breast cancer. However, new aromatase inhibitors that are many times more potent and specific than the first such agent, aminoglutethimide, are changing the management of breast cancer in postmenopausal women. This review discusses the role of aromatase inhibitors such as letrozole, anastrozole, and exemestane in the treatment of breast cancer.
PREOPERATIVE SERIAL GALLIUM-67 CITRATE IMAGING AS A PROGNOSTIC INDICATOR IN EXTREMITY SARCOMA
Authors: C R Divgi, J A Burrell, J L Mayoral, A G Huvos, S D J Yeh, R V Grando, R S Benua
Journal: Clinical Nuclear Medicine (1987)

Divgi, C R; Burrell, J A; Mayoral, J L; Huvos, A G; Yeh, S D J; Grando, R V; Benua, R S Author Information
Gene Therapies for the Hemophilias
Authors: Arthur R. Thompson
Journal: Molecular Therapy (2000)

A wide variety of viral and nonviral vector strategies are being explored for gene transfer of factors VIII and IX, and expression systems are being optimized. Although gene repair is often problematic, efforts to develop this area may yield a very safe approach for patients with point mutations. Indeed, a variety of approaches may be useful for different patients. Although factor replacement therapy is currently effective at managing most bleeding episodes after they occur, not all complications are prevented. Gene therapy for the hemophilias could provide continuous protection if not a cure. This is especially critical for the two-thirds of hemophilic patients in countries where no concentrate therapy is available. If cost-effective efforts to identify and properly diagnose these patients could be followed by a simple procedure capable of creating prolonged in vivo expression, gene therapy for the hemophilias will have a significant worldwide impact.
Brief Psychotherapy with Children: A Preliminary Report
Authors: ALAN J. ROSENTHAL, SAUL V. LEVINE
Journal: American Journal of Psychiatry (1970)

The authors present some of the results of their pilot study to test the efficacy of brief psychotherapy with 33 children with various disorders and to compare its usefulness with traditional, long-term psychotherapy with a control group of 35 children. More than half the experimental group were successfully treated and maintained their improvement over the one-year follow-up period. The authors also discuss criteria for the selection of subjects and techniques for treatment that may improve the rate of success achieved with brief psychotherapy.
Endoscopy With Endoscopic Cholangiopancreatography
Authors: David S. Zimmon
Journal: JAMA (1975)

The combination of upper gastrointestinal endoscopy and endoscopic retrograde cholangiopancreatography was evaluated as a primary diagnostic procedure in 91 consecutive patients suspected of pancreatic or biliary tract disease. In 77 (85%) of the patients, the origin, nature, or extent of disease was established by endoscopy (13 patients), pancreatography (25 patients), or cholangiography (39 patients). This combined technique compares favorably with other means of diagnosing pancreatic or biliary tract disease.
Effect of particle size reduction on dissolution and oral absorption of a poorly water-soluble drug, cilostazol, in beagle dogs
Authors: Jun-ichi Jinno, Naoki Kamada, Masateru Miyake, Keigo Yamada, Tadashi Mukai, Masaaki Odomi, Hajime Toguchi, Gary G. Liversidge, Kazutaka Higaki, Toshikiro Kimura
Journal: Journal of Controlled Release (2006)
Symmetrical Gangrene in the African
Authors: A. D. Charters, P. E. C. Manson-Bahr
Journal: BMJ (1948)

MDICAL JOURNALvisit (day, night, Sundays), and minor operations.The patient pays his doctor, who initials a receipt provided by the social security organization.The fee is later refunded minus 20%.The advantages of this system are many and amply compensate the slightly more complicated administrative machine which is needed. (a) The patient has complete freedom to choose or change his doctor. (b) The doctor-patient relationship is preserved, as the State enters into a contract with the patient and not with the doctor.(c) The doctor is not called out for trivial complaints, as the patient must pay out of his own pocket one-fifth of the fee.(d) The more experienced doctor or the older physician may raise his fees (within accepted limits) to lessen the burden of his practice.This system works well, and I have no doubt a similar system could be devised to meet our needs.-Iam, etc.,