Effect of Rifampin Therapy on Thyroid Function Tests in a Hypothyroid Patient on Replacement L-Thyroxine
Authors: WILLIAM L. ISLEY
Journal: Annals of Internal Medicine (1987)

Brief Reports1 October 1987Effect of Rifampin Therapy on Thyroid Function Tests in a Hypothyroid Patient on Replacement L-ThyroxineWILLIAM L. ISLEY, M.D.WILLIAM L. ISLEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-4-517 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNormal volunteers treated with rifampin, a potent inducer of liver microsomal enzymes, have significant decreases in serum thyroxine levels and free thyroxine index but no changes in basal or stimulated thyrotropin levels (1-3). We report the case of a patient with primary hypothyroidism receiving a constant replacement dose of L-thyroxine who developed biochemical hypothyroidism when treated with rifampin.A 31-year-old woman with Turner syndrome and hypertension was admitted with dizziness, nausea, and vomiting. Fifteen months earlier she had had a total thyroidectomy for a rapidly enlarging goiter, which was complicated by hypoparathyroidism and recurrent laryngeal nerve palsy. Pathologic examination of...References1. OHNHAUS E and STUDER H. The effect of different doses of rifampicin on thyroid hormone metabolism. Br J Clin Pharmacol. 1980;9:285P-6P. CrossrefMedlineGoogle Scholar2. OHNHAUS E, BÜRGI H, BURGER A, and STUDER H. The effect of antipyrine, phenobarbitol, and rifampicin on thyroid hormone metabolism in man. Eur J Clin Invest. 1981;11:381-7. CrossrefMedlineGoogle Scholar3. OHNHAUS E and STUDER H. A link between liver microsomal enzyme activity and thyroid hormone metabolism in man. Br J Clin Pharmacol. 1983;15:71-6. CrossrefMedlineGoogle Scholar4. BRENT G, HERSHMAN J, and BRAUNSTEIN G. Patients with severe nonthyroidal illness and serum thyrotropin concentrations in the hypothyroid range. Am J Med. 1986;81:463-6. CrossrefMedlineGoogle Scholar5. GREGERMAN R and SOLOMON N. 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Interaction of chronic daily warfarin therapy and rifampin. Ann Intern Med. 1975;83:506-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM L. ISLEY, M.D.Affiliations: University of Missouri-Kansas City School of Medicine Kansas City, Missouri PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMyxedema coma following rifampicin – A clinical case and literature reviewEffect of Rifampin on Thyroid Function Test in Patients on Levothyroxine MedicationHypothyroidismThyroid Function TestingHypothyroidism and Myxedema ComaGuidelines for the Treatment of Hypothyroidism: Prepared by the American Thyroid Association Task Force on Thyroid Hormone ReplacementCiprofloxacin and Rifampin Have Opposite Effects on Levothyroxine AbsorptionThe Effect of Medications on Thyroid Function TestsHypothyroidism and ThyroiditisInfluence of Drugs on Thyroid Function TestsThyroid Function TestingHypothyroidism and Myxedema ComaRifampin-Induced Hypothyroidism without Underlying Thyroid DiseaseRifampin-induced hypothyroidismThyroid function in human immunodeficiency virus patients treated with highly active antiretroviral therapy (HAART): a longitudinal studyRifampin-Induced Hypothyroidism in Patients with Hashimoto's ThyroiditisA Case of Celiac Disease Presenting With Malabsorption of l-ThyroxineHypothyroidismOptimizing Treatment of HypothyroidismAnnouncementClinically Significant Interactions with Drugs Used in the Treatment of TuberculosisWHEN TO TREAT MILD HYPOTHYROIDISMENDOCRINOLOGIC COMPLICATIONS OF HIV INFECTIONEndocrine Implications of Human Immunodeficiency Virus InfectionDrugs and Thyroid FunctionRapid changes in thyroid function tests upon treatment of tuberculosisEndocrine Complications of AIDS and Drug AddictionThyrotoxicosis in the Critically IllReview: Hypothyroidism in the Elderly 1 October 1987Volume 107, Issue 4Page: 517-518KeywordsHypothyroidismNervesParalysisResearch laboratoriesThyroidThyroid-stimulating hormoneThyroidectomyThyroxineTurner syndromeVomiting ePublished: 1 December 2008 Issue Published: 1 October 1987 PDF downloadLoading ...