tbuckley/cabot-search huggingface dataset:
Conveyance of Yellow Fever.
Authors: H. R. Carter
Journal: JAMA (1901)

Baltimore, Md., April 20, 1901. <h3>To the Editor:</h3> —Relative to the editorial notice inThe Journalof the 13th. on a paper of mine that appeared in the<i>Philadelphia Medical Journal</i>of April 6, "on the Corelation of the Theory of Conveyance of Yellow Fever by the Culex Fasciatus, with our Generally Accepted Beliefs," I would say: 1. My paper was written about the first of December last, when Finlay's experiments and Major Reed's "Preliminary Note" were the only<i>direct</i>evidence extant in favor of the conveyance of yellow fever by the mosquito as a host. Neither of these seeming to me—nor, I think, to others—fully convincing I attempted to compare this theory, without regard to this evidence, with what was known and admitted on the subject, to try to determine if it were antecedently probable or improbable. The paper is confined to a bare statement of the case, purposely
An Inaugural Address ON BIER'S HYPERAEMIC TREATMENT: Delivered to the Willesden and District Medical Society, October 20th, 1911
Authors: H. F. Waterhouse
Journal: BMJ (1911)

rAFTER. a referelnce to the address he gave thlree years ago to the Soutlh Midland Branch of the Britislh Medical Association, puLblished in the BRITISII MEDICAL JOUITRNAL of
<i>In vitro</i> Benzo[<i>a</i>]pyrene Diol Epoxide–Induced DNA Adducts and Risk of Squamous Cell Carcinoma of Head and Neck
Authors: Donghui Li, Li-E Wang, Ping Chang, Adel K. El-Naggar, Erich M. Sturgis, Qingyi Wei
Journal: Cancer Research (2007)

Abstract In this large confirmatory study of 803 patients with squamous cell carcinoma of head and neck (SCCHN) and 839 controls frequency matched by age, sex, and ethnicity, we further examined potential predictors of benzo[a]pyrene diol epoxide (BPDE)-induced adduct levels and their associations with SCCHN risk. BPDE-DNA adduct levels were determined by the 32P-postlabeling method in peripheral lymphocytes after in vitro challenged by BPDE. We also genotyped for GSTM1 null, GSTT1 null, GSTP1 Ile105Val, and GSTP1 Ala114Val. Potential predictors of BPDE-DNA adducts were evaluated by stratification and multivariate linear regression analyses and the association between adduct levels and SCCHN risk by multivariate logistic regression analyses. We found that mean BPDE-DNA adduct levels (the relative adduct labeling × 107 ± SD) were significantly higher in cases (77.6 ± 111.8) than in controls (57.3 ± 98.3; P &amp;lt; 0.001). Using the median control value (29.22) as a cutoff, 63% of the cases were distributed above this level (adjusted odds ratio, 1.71; 95% confidence interval, 1.39–2.10). A significant dose-response relationship was observed between adduct quartiles and SCCHN risk (Ptrend &amp;lt; 0.001). Multivariate linear regression analysis revealed that ethnicity and smoking were significant predictors of BPDE-DNA adduct levels in controls. In conclusion, we confirmed the previously reported association between in vitro BPDE-induced DNA adduct levels and SCCHN risk, and the assay may help identify individuals at high risk of developing smoking-related cancers. [Cancer Res 2007;67(12):5628–34]
No easy way to deal with violence
Authors: T. McCullagh
Journal: BMJ (1996)

Violence against people and property is commonplace in the inner city. This makes it no less distressing. Yesterday I had two separate consultations involving patients, one man, one woman, who had been mugged the previous day. The first was a security officer who had been violently attacked with a club over a parking dispute at work. He was offered no formal help from his employers or the police. He asked for two weeks' sick leave. I gave him the certificate.

The second victim was a young mother who was entering her house with her 5 year old daughter at dusk. She was approached by two youths; one black, one white. One of them grabbed her from behind while the other punched and pushed her to the ground, snatching her handbag, and running off with it. “Neither of them spoke a word,” she said. This violent choreography was over in seconds, leaving her numb and disoriented. Now, seated in front of me, she was composed. “By the sheer arbitrariness of their act they have condemned me to change my behaviour… . I will no longer carry a handbag.” She had been crying all morning over the telephone to her friends, feeling the anger, the humiliation, and the power-lessness. Now she left to return to work, recognising that for her the normal daily contact with the familiar would start a …
Paraoxonase-1 is a major determinant of clopidogrel efficacy
Authors: Heleen J Bouman, Edgar Schömig, Jochem W van Werkum, Janna Velder, Christian M Hackeng, Christoph Hirschhäuser, Christopher Waldmann, Hans-Günther Schmalz, Jurriën M ten Berg, Dirk Taubert
Journal: Nature Medicine (2010)
Plasma secretin and pancreatic bicarbonate response to exogenous secretin in man.
Authors: W H HACKI, S R Bloom, P Mitznegg, W Domschke, S Domschke, D Belohlavek, L Demling, E Wunsch
Journal: Gut (1977)

The dose response of duodenal bicarbonate production during synthetic porcine secretin infusions was studied in six healthy volunteers and related to plasma secretin immunoreactivity. Secretin was infused in each individual at four different doses from 0-1 to 2-7 CU/kg/h, each infusion lasting for 60 minutes. Mean maximal bicarbonate secretion was 33 +/- 4 mEq/h. The secretin plasma level for half maximal bicarbonate response was estimated to be 22 pmol/l. As this level is reported to be achieved by intraduodenal acidification in man, it is concluded that secretin may well play a part in the control of duodenal pH.
Pregnant Surgical Residents: Oh K?!
Authors: Brian J. Bohlmann
Journal: JAMA (1991)

To the Editor.  —The editorial by Drs Huang and Jonasson 1 raises important concerns about pregnancy during postgraduate training. Such training overlaps with a woman's childbearing years, and one cannot reasonably expect female physicians to delay childbearing indefinitely. However, insufficient attention has been given to the implementation of family leave policies. The authors mention three recent pregnancies among residents in their general surgery program and state that pregnant residents are assigned to lighter services during the last trimester. Six weeks' pregnancy leave is also allowed. They conclude: Coresidents have cooperated fully, especially since they are not expected to fill in or take additional duty hours. The authors do not describe how three residents could be on light duty for 3 months each and absent for another 6 weeks each—all without imposing additional duties on the other residents.  I think that the authors have benefited from an atypical confluence of favorable
EXCELLENT EARLY RISK STRATIFICATION USING TROPONINS AND N-TERMNIAL PRO-BRAIN NATRIURETIC PEPTIDES IN CHEST PAIN PATIENTS BUT NO ADDITIONAL VALUE OF HIGH-SENSITIVE TROPONIN T
Authors: Dina Melki, Suzanne Lind, Stefan Agewall, Tomas Jernberg
Journal: Journal of the American College of Cardiology (2011)
West Nile Encephalitis in Massachusetts
Authors: Leigh R. Hochberg, John R. Sims, Benjamin T. Davis
Journal: New England Journal of Medicine (2002)

To the Editor: We describe one of the two sentinel cases of West Nile encephalitis that have occurred in humans in Massachusetts. Both cases involved elderly Massachusetts residents, one of whom died from West Nile virus infection in mid-October, and both were diagnosed simultaneously. An 89-year-old man presented to a community hospital in October 2001 with fever and confusion. Except for recurrent hematuria, he had been in good health until the day before admission. After going to sleep unusually early, he awoke confused at 12:30 a.m. and slumped to the floor. His initial evaluation was notable for fever (oral temperature, . . .
ALLERGY AND ALKALOSIS
Authors: Samuel M. Feinberg
Journal: JAMA (1931)

<h3>To the Editor:</h3> —InThe Journal, Nov. 22, 1930, page 1582, Beckman again proposes that allergy is a potential alkalosis, and suggests the acid treatment, particularly in hay-fever. He bases his hypothesis on the following considerations: "Allergic" phenomena cannot all be explained by allergy. The theory of alkalosis can be supported by the fact that in conditions in which acidosis is increased allergic manifestations are benefited. The conditions he enumerates are diabetes mellitus, starvation, pregnancy, acute infectious diseases, sea voyage, sojourning at high altitude, asthma in the young, increasing the gastric acidity, calcium therapy, and the use of whisky and acetylsalicylic acid. The successful use of mineral acid therapy in hay-fever. The following facts do not support Dr. Beckman's thesis: 1. Although "allergic" phenomena cannot all be explained by allergy, it is still more difficult to explain them on the basis of alkalosis. It is still more confusing to find
Antimetastatic Activity of a Novel Mechanism-Based Gelatinase Inhibitor
Authors: Achim Krüger, Matthias J.E. Arlt, Michael Gerg, Charlotte Kopitz, M. Margarida Bernardo, Mayland Chang, Shahriar Mobashery, Rafael Fridman
Journal: Cancer Research (2005)

Abstract Matrix metalloproteinases (MMPs), and in particular gelatinases (MMP-2 and MMP-9), play a key role in cancer progression. However, clinical trials in which MMP inhibitors were tested in cancer patients have been disappointing. Whereas many reasons have been postulated to explain the failure of the clinical trials, lack of inhibitor selectivity was a major limitation. Thus, despite the consensus opinion that MMP-mediated proteolysis is essential for cancer progression and that certain MMPs represent important targets for intervention, effective and selective inhibition of those MMPs remains a major challenge in drug development. We previously reported the first mechanism-based MMP inhibitor, designated SB-3CT, which is a selective gelatinase inhibitor. Here we report that SB-3CT (5-50 mg/kg/d) is a potent inhibitor of liver metastasis and increases survival in an aggressive mouse model of T-cell lymphoma. This study shows that mechanism-based inhibition of gelatinases represents a novel approach to inhibitor design that promises to be a successful anticancer therapy.
Differences in the Expression Profiles of Excision Repair Crosscomplementation Group 1, X-Ray Repair Crosscomplementation Group 1, and βIII-Tubulin Between Primary Non-small Cell Lung Cancer and Metastatic Lymph Nodes and the Significance in Mid-Term Survival
Authors: Chang Hyun Kang, Bo Gun Jang, Dong-Wan Kim, Doo Hyun Chung, Young Tae Kim, Sanghoon Jheon, Sook-Whan Sung, Joo Hyun Kim
Journal: Journal of Thoracic Oncology (2009)
Soundbites and patient centred care
Authors: P. Dieppe
Journal: BMJ (2002)

Former prime minister Harold Macmillan famously once said, "You've never had it so good," thereby inventing a classic soundbite.It could be argued that health care has never had it so good-we are enjoying access to an unprecedented range of powerful and effective means of combating disease and illness; we are living longer, healthier lives; and spending on health care has never been so high.However, expectations have risen faster than improved healthcare delivery, which has resulted in major political and financial pressures on the NHS, and mounting public dissatisfaction.There is concern, too, that health professionals remain too aloof, paternalistic, and controlling to suit the needs of their patients.We need more "patient centred health care," it is claimed.
Elucidation of Acute Renal Failure Due to Recurrent Non-Hodgkin Lymphoma by F-18 FDG PET/CT
Authors: Faizatul I. Rozalli, Siew C. Chua, Desmond J. Green
Journal: Clinical Nuclear Medicine (2008)

Renal impairment secondary to lymphomatous parenchymal infiltration is uncommon. Early recognition of this cause of acute renal failure (ARF) is important as initiation of steroid therapy often results in rapid improvement in renal function. We highlight the usefulness of the functional aspect F-18 FDG PET/CT in demonstrating the cause of unexplained ARF in a patient with recurrent non-Hodgkin lymphoma (NHL) due to a combination of unilateral outflow obstruction by nodal disease in a chronically atrophic kidney and lymphomatous infiltration of the contralateral kidney with resultant nonexcretion.
Market-Based Solutions to Antitrust Threats — The Rejection of the Partners Settlement
Authors: Regina E. Herzlinger, Barak D. Richman, Kevin A. Schulman
Journal: New England Journal of Medicine (2015)

Interview with Prof. Barak Richman on hospital mergers and the decision in the Partners HealthCare case. (14:44)Download A judge has blocked a settlement that would have allowed Boston's Partners HealthCare to acquire three more health care providers. But policies should not only stop dominant hospital systems from acquiring more power but also encourage innovative entrants.
Pregnancy, Addiction, and Incarceration
Authors: Kevin Fiscella
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 3536: Depletion of regulatory T lymphocytes reverses the imbalance between Pro- and anti-tumor immunities via enhancing antigen-specific T cell immune responses
Authors: Yu-Li Chen, Ming-Cheng Chang, Chia-Yen Huang, Ying-Cheng Chang, Yun-Yuan Chen, Ju-Ming Wang, Wen-Fang Cheng
Journal: Cancer Research (2012)

Abstract Immunogenicity is the ability of antigens to elicit an immune response. The host immunity for anti-tumor can be induced because of the existence of tumor-specific and/or tumor-associated antigens. However, the most effective immune manipulation for ovarian carcinoma is eagerly awaited. To explore the systemically and locally kinetic changes of immunologic profiles during tumor progression and to elucidate the inhibition of tumor growth and the reverse of immunologic profiles by depletion of Treg cells in ovarian carcinomas, ovarian cancer patients and the ascitogenic animal model were employed. Immunologic profiles with flow cytometric analyses, immunohistochemistric staining, RT-PCR, ELISA, and ELISPOT assays were performed. In vivo depletion of Treg cells with the mAb PC61was also performed in the animal model. Including the anti-inflammatory cytokines IL-4 and TNF-α significantly decreased, TGF-β, IL-6, IL-10 significantly elevated in human ascites when the disease progressed to advanced diseases. The ratios of CD8+ T cell/Treg cell in the tumor asociated lymphocytes of the human ascites were lower in advanced diseases than those in early diseases. These alterations of immune components during tumor progression were proved in our animal model. Mice, when treated with kinetic low dose of mAb PC61, showed longer survival than the other groups. Tumor-bearing mice treated with kinetic low dose mAb PC61could inhibit the suppressive immunologic profiles, enhance the effective immunologic profiles, and generate potent antigen-specific anti-tumor immunities and effects. We concluded that the imbalance between effective and suppressive immunities could be identified in tumor-bearing situation, especially in advanced diseases. The depletion of Treg cells could correct the immunologic profiles and generate potent antigen-specific immunity. The strategy of targeting Treg cells can be a new strategy for the immunotherapy of ovarian carcinoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3536. doi:1538-7445.AM2012-3536
Integrating HIV Prevention Into Practice
Authors: Bradley M. Mathers, David A. Cooper
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PRESSOR SUBSTANCES IN ARTERIAL HYPERTENSION
Authors: Norman S. Olsen, Henry A. Schroeder
Journal: The Journal of Experimental Medicine (1950)

Pherentasin, a material producing a prolonged pressor response in rats, has been procured from the arterial blood of hypertensive patients and purified. Pherentasin is of small molecular size, non-protein in nature, dialyzable, soluble in water and 90 per cent ethanol, and extractable into organic solvents from alkaline solution. It contains an amino group essential to activity, which is probably primary, and also contains an active carbonyl group. It has been found in concentrations up to approximately 20 gamma per liter of blood.
Children in the Gaza Strip suffer malnutrition
Authors: L. Eaton
Journal: BMJ (2002)

The Palestinian Ministry of Health has declared a nutritional emergency, after a study from a leading aid organisation showed the extent of malnutrition among children living in the West Bank and Gaza Strip.

Care International, a humanitarian agency that emphasises the importance of self help, has recently published the results of three surveys carried out with the help of the Johns Hopkins University Emergency Medical …
Cardiovascular Effects of Acrylic Bone Cement in Rabbits and Cats
Authors: D. Pelling, K. R. Butterworth
Journal: BMJ (1973)

The cardiovascular responses to forcing acrylic bone cement, Plasticine, or soft paraffin wax into the medullary cavity of the femur have been studied in rabbits and cats. An acute fall in blood pressure, occurring within a few seconds of insertion, was demonstrated with each substance. In a few of the animals the blood pressure response had a second more protracted component and it is suggested that more than one mechanism is involved. The cardiovascular effects that have been observed in man when acrylic cement is used in prosthetic hip surgery also may be due to more than one mechanism.
Ranitidine in the prevention of gastric and duodenal ulcer relapse.
Authors: E M Alstead, F P Ryan, C D Holdsworth, M G Ashton, M Moore
Journal: Gut (1983)

Prophylactic maintenance therapy for one year using ranitidine 150 mg at night or a placebo was assessed in 68 patients whose gastric or duodenal ulcers had previously healed after therapy with ranitidine 150 mg twice daily or placebo. Gastroscopy was carried out on symptomatic relapse and at the end of the year. Of the duodenal ulcer group, seven out of 20 relapsed on ranitidine compared with 15 out of 17 on placebo (p less than 0.001). Of the gastric ulcer group one of 15 patients relapsed on ranitidine compared with 11 of 16 patients on placebo (p less than 0.005). There were no adverse effects from ranitidine during the trial period. Ranitidine in low dose maintenance therapy is therefore reasonably effective in the prevention of relapse of duodenal ulcers and appears to be particularly effective in preventing relapse of gastric ulcers at least for one year. As gastric ulcers occur more frequently in the older patients in whom there are often medical contraindications to surgery, maintenance treatment may be appropriate for many such patients.
Book Review Asthma Third edition. Edited by T.J.H. Clark, S. Godfrey, and T.H. Lee. 622 pp., illustrated. New York, Chapman and Hall, 1992. $95.95. ISBN 0–442–31582–1 . (Distributed in the U.S. by Van Nostrand Reinhold, New York.)
Authors: Chester T. Stafford
Journal: New England Journal of Medicine (1992)
The visualization of plasma membrane receptors
Authors: B. J. VERMEER, J. G. SCHROEFF, J. J. EMEIS
Journal: British Journal of Dermatology (1982)

Using LDL receptors as a model for studying class II polypeptide receptors we could demonstrate by immunofluorescence that LDL receptor activity is inversely related to cell density. The LDL receptors are linearly arranged on the cell surface, and prefixation of the cells with 1% p‐formaldehyde does not abolish the binding of LDL. Immunoelectron microscopical studies showed that bound LDL is pre‐dominantly located in coated pits on the plasma membrane and was internalized at 37° C within 20 min.
How to Evaluate a Diagnostic Marker Test
Authors: Andrew A. Nierenberg
Journal: JAMA (1988)

To understand why the dexamethasone suppression test (DST) for the diagnosis of depression became widely accepted and later rejected, we reviewed the sequence of publications in the DST literature. To evaluate the events, we developed and applied concepts of a five-phase process that can be used to assess the clinical utility of diagnostic marker tests. The review showed that when the DST was introduced into the clinical arena, the initial and final two phases of testing (I, IV, and V) had not been adequately conducted. When these phases of testing were suitably checked many years later, the Phase I studies (exploring basic mechanics of test procedures) showed that dexamethasone had variable bioavailability and that the cortisol assay procedure was unreliable. The Phase IV and V studies (examining test results in groups with suitably broad spectrums of cases and controls) showed that the test did not differentiate depression from most pertinent comorbid conditions. Beyond application to the specific problems of the DST, the proposed five phases of development and evaluation for diagnostic marker tests can be used to plan suitable research and avoid similar problems in the future.
Translation from a DMD exon 5 IRES results in a functional dystrophin isoform that attenuates dystrophinopathy in humans and mice
Authors: Nicolas Wein, Adeline Vulin, Maria S Falzarano, Christina Al-Khalili Szigyarto, Baijayanta Maiti, Andrew Findlay, Kristin N Heller, Mathias Uhlén, Baskar Bakthavachalu, Sonia Messina, Giuseppe Vita, Chiara Passarelli, Simona Passarelli, Matteo Bovolenta, Marcella Neri, Francesca Gualandi, Steve D Wilton, Louise R Rodino-Klapac, Lin Yang, Diane M Dunn, Daniel R Schoenberg, Robert B Weiss, Michael T Howard, Alessandra Ferlini, Kevin M Flanigan
Journal: Nature Medicine (2014)