tbuckley/cabot-search huggingface dataset:
Knowledge and Practices of Generalist and Specialist Physicians Regarding Drug Therapy for Acute Myocardial Infarction
Authors: John Z. Ayanian, Paul J. Hauptman, Edward Guadagnoli, Elliott M Antman, Chris L. Pashos, Barbara J. McNeil
Journal: New England Journal of Medicine (1994)

The respective roles of generalist and specialist physicians in the care of patients are currently a matter of debate. Information is limited about the knowledge and practices of generalist and specialist physicians regarding conditions that both groups treat, such as myocardial infarction.
Adolescent Patients and Internal Medicine
Authors: LAWRENCE J. D'ANGELO
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 December 1983Adolescent Patients and Internal MedicineLAWRENCE J. D'ANGELO, M.D., M.P.H.LAWRENCE J. D'ANGELO, M.D., M.P.H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-6-884_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent article by Rapp (1) was an important introduction to some of the special issues that confront the practitioner who treats adolescent and young adult patients. However, it was not clear how often internists could be expected to need the skills and knowledge outlined. Recent data (2) show that patients between the ages 15 and 24 years make almost 8% of all visits to internists. This figure represents 6.2% of all visits to physicians made by individuals in this age group and 7.1% of all non-pregnancy-related visits. Younger adolescents, those between ages 11 and 14, constitute...References1. RAPP C. The adolescent patient. Ann Intern Med. 1983;99:52-60. LinkGoogle Scholar2. The National Ambulatory Medical Care Survey, United States, 1979 Summary. Hyattsville, Maryland: National Center for Health Statistics; 1982. (DHHS publication no. PHS 82-1727. Vital and Health Statistics; Series 13, no. 66). Google Scholar3. STRASBURGER V. Who speaks for the adolescent? JAMA. 1983;249:1021. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Children's Hospital National Medical Center Washington, D.C. 20010 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1983Volume 99, Issue 6Page: 884-884KeywordsAdolescent medicineAdolescentsAge groupsYoung adults Issue Published: 1 December 1983 PDF DownloadLoading ...
Serotonin and affiliative behavior
Authors: Simon N. Young, D. S. Moskowitz
Journal: Behavioral and Brain Sciences (2005)

the possible role of the neurotransmitter serotonin in human affiliative behavior is under-examined in the review by depue &amp; morrone-strupinsky (d&amp;m-s). this commentary reviews evidence indicating that serotonin not only inhibits aggressive behavior that may be detrimental to affiliative bonds with others in a social group but serotonin also enhances prosocial behaviors that may facilitate ties to the social group.
Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-β receptor expression
Authors: Frederik Stevenaert, Katrien Van Beneden, Veerle De Colvenaer, Ann Sophie Franki, Veronique Debacker, Tom Boterberg, Dieter Deforce, Klaus Pfeffer, Jean Plum, Dirk Elewaut, Georges Leclercq
Journal: Blood (2005)
New Paradigm in Dose-Finding Trials: Patient-Specific Dosing and Beyond Phase I
Authors: André Rogatko, James S. Babb, Mourad Tighiouart, Fadlo R. Khuri, Gary Hudes
Journal: Clinical Cancer Research (2005)

We propose a new paradigm for the clinical evaluation of new cancer therapies. It entails adjusting the search for the optimal dose on the basis of measurable patient characteristics that may be predictive of adverse responses to treatment, and extending this search beyond phase I and into phases II and III. We provide examples of (a) how the fine-tuning of dose may involve utilization of patient-specific attributes to obtain a personalized treatment regimen, and (b) how novel methods for phase I design can be used to update the working dose for the conduct of phase II and III cancer clinical trials. These examples should be interpreted as an enticement for the development of new methods to implement the proposed new paradigm.
LONG-TERM CLINICAL RESULTS OF ADVERSE OUTCOMES AFTER DRUG-ELUTING STENT IMPLANTATION FOR BIFURCATION LESIONS IN A REAL-WORLD PRACTICE &amp;ndash; RESULTS FROM THE COBIS (CORONARY BIFURCATION STENTING) II REGISTRY -
Authors: Jeong Hoon Yang, Pil Sang Song, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Jin-Ho Choi, Hyo-Soo Kim, Seung-Woon Rha, Cheol Woong Yu, Jong-Seon Park, Jin-Ok Jeong, Hyeon-Cheol Gwon
Journal: Journal of the American College of Cardiology (2012)
A psychobiological theory of attachment
Authors: Gary W. Kraemer
Journal: Behavioral and Brain Sciences (1992)

This article describes a neurobiological basis for the "first attachment" of the primate infant to its caretaker. The infant normally internalizes a neurobiological "image" of the behavioral and emotional characteristics of its caregiver that later regulates important features of its brain function. Current models of sensorimotor analysis and its relation to emotion suggest that sensorimotor systems are also habit and memory systems, their functional status and lability regulated in part by biogenic amine systems. The intertwined development of neural and social functions can sometimes go awry. If the attachment process fails or the caregiver is incompetent, the infant may become socially dysfunctional. This helps explain the developmental psychopathology and later vulnerability to adult psychopathology that result from disruptions of social attachment.
The Febrile Response in Acute Otitis Media
Authors: Richard H. Schwartz
Journal: JAMA (1981)

Of 671 children with acute otitis media seen in our private practice, only 23% had fever. Very high fever (≥40.5 °C) was noted in only two children. In only 4% of the 671 children did the fever last more than 48 hours after antibiotic treatment had been started. We found that the organism causing the acute otitis media was unrelated to the presence of fever associated with this illness. (<i>JAMA</i>1981;245:2057-2058)
NO REFLOW PHENOMENON PREDICTS LEFT VENTRICULAR SYSTOLIC DYSFUNCTION BUT DOES NOT PREDICT LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN PATIENTS WITH REPERFUSED THEIR FIRST ACUTE MYOCARDIAL INFARCTION
Authors: Shigemiki Omiya, Katsuomi Iwakura, Atsunori Okamura, Kenshi Fujii
Journal: Journal of the American College of Cardiology (2012)
The Use of Scintigraphic Studies in Mid-ventricular Obstructive Cardiomyopathy to Rule Out Pseudoaneurysm
Authors: CHAN H. PARK, HOWARD A. LEVY, MICHAEL SAVAGE
Journal: Clinical Nuclear Medicine (1985)

A "pseudo-pseudo" aneurysm of the left ventricle due to mid-ventricular obstruction from asymmetric septal hypertrophy is presented. A case of mid-ventricular hypertrophic obstructive cardiomyopathy (MVHOCM) was evaluated by means of echocardiography, angiocardiography, gated cardiac blood pool scanning, and a TI-201 myocardial scan. The gated cardiac blood pool scan appearance of MVHOCM is similar to pseudoaneurysm of the left ventricle. TI-201 myocardial imaging, however, was able to distinguish between MVHOCM and pseudoaneurysm of the left ventricle.
Tetrachloroethylene (PCE, Perc) Levels in Residential Dry Cleaner Buildings in Diverse Communities in New York City
Authors: Michael J. McDermott, Kimberly A. Mazor, Stephen J. Shost, Rajinder S. Narang, Kenneth M. Aldous, Jan E. Storm
Journal: Environmental Health Perspectives (2005)

Fugitive tetrachloroethylene (PCE, perc) emissions from dry cleaners operating in apartment buildings can contaminate residential indoor air. In 1997, New York State and New York City adopted regulations to reduce and contain perc emissions from dry cleaners located in residential and other buildings. As part of a New York State Department of Health (NYSDOH) study, indoor air perc levels were determined in 65 apartments located in 24 buildings in New York City where dry cleaners used perc on site. Sampling occurred during 2001-2003, and sampled buildings were dispersed across minority and nonminority as well as low-income and higher income neighborhoods. For the entire study area, the mean apartment perc level was 34 microg/m3, 10-fold lower than mean apartment levels of 340-360 microg/m3 documented before 1997. The maximum detected perc level was 5,000 microg/m3, 5-fold lower than the maximum of 25,000 microg/m3 documented before 1997. Despite these accomplishments, perc levels in 17 sampled apartments still exceeded the NYSDOH residential air guideline of 100 microg/m3, and perc levels in 4 sampled apartments exceeded 1,000 microg/m3. Moreover, mean indoor air perc levels in minority neighborhoods (75 microg/m3) were four times higher than in nonminority households (19 microg/m3) and were > 10 times higher in low-income neighborhoods (256 microg/m3) than in higher income neighborhoods (23 microg/m3). Logistic regression suitable for clustered data (apartments within buildings) indicated that perc levels on floors 1-4 were significantly more likely to exceed 100 microg/m3 in buildings located in minority neighborhoods (odds ratio = 6.7; 95% confidence interval, 1.5-30.5) than in nonminority neighborhoods. Factors that may be contributing to the elevated perc levels detected, especially in minority and low-income neighborhoods, are being explored.
Gerontology and Geriatrics in Medical Education
Authors: Peter E. Dans, Marie R. Kerr
Journal: New England Journal of Medicine (1979)

Abstract The elderly are receiving more attention because of their increasing numbers and because of the substantial public funding for their health and welfare. This article summarizes the findings of an Institute of Medicine committee, whose recently completed report concludes that gerontology (study of aging) and geriatrics (care of the aged) are not covered adequately in medical education. Suggested remedies include increased attention to these subjects in existing medical-school courses, establishment of a complementary required course integrating information from diverse disciplines and emphasis in house-staff training programs on continuous care of the aged in settings other than acute-care facilities. Although an academic discipline of geriatrics is necessary to enhance teaching, research, and specialized patient care, development of a practice specialty would be unwise. More funds for training and research in gerontology and geriatrics are essential to increase the science base and to encourage the development of knowledgeable faculty. (N Engl J Med 300:228–232, 1979)
A comparison of thermodilution coronary sinus blood flows and krypton myocardial blood flows in the intact dog
Authors: ALLEN. B. WEISSE, T. J. REGAN
Journal: Cardiovascular Research (1974)

Journal Article A comparison of thermodilution coronary sinus blood flows and krypton myocardial blood flows in the intact dog Get access ALLEN. B. WEISSE, ALLEN. B. WEISSE 2 From the Department of Medicine, College of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, USA 2Correspondence to: Allen B. Weisse, MD, College of Medicine and Dentistry of New Jersey, New Jersey Medical School, 100 Bergen Street, Department of Medicine, Newark, New Jersey 07103, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar TIMOTHY J. REGAN TIMOTHY J. REGAN From the Department of Medicine, College of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 8, Issue 4, July 1974, Pages 526–533, https://doi.org/10.1093/cvr/8.4.526 Published: 01 July 1974
High Dose Bolus Heparin as Initial Therapy Before Primary Angioplasty for Acute Myocardial Infarction: Results of the Heparin in Early Patency (HEAP) Pilot Study
Authors: Freek W.A Verheugt, Aylee Liem, Felix Zijlstra, Randall C Marsh, Gerrit Veen, Jean G.F Bronzwaer
Journal: Journal of the American College of Cardiology (1998)
The Burden of Health Care Costs for Working Families — Implications for Reform
Authors: Daniel Polsky, David Grande
Journal: New England Journal of Medicine (2009)

On June 2, 2009, President Barack Obama's Council of Economic Advisers released a report examining the economic case for health care reform, in which they underscored the importance of cost containment to the long-term sustainability of any reform.1 Despite widespread recognition of the importance of containing costs, political support for this agenda is limited by the fact that those who shoulder the financial burden of maintaining the current system — primarily, working families — are not fully aware of that burden's full weight.Having constructed a typical health care budget for working families of various income levels, we found that . . .
White matter lesions are associated with the results of 123I-metaiodobenzylguanidine myocardial scintigraphy in type 2 diabetes mellitus patients
Authors: Futoshi Anan, Takayuki Masaki, Tetsuji Shinohara, Kunio Yufu, Naohiko Takahashi, Mikiko Nakagawa, Nobuoki Eshima, Tetsunori Saikawa, Hironobu Yoshimatsu
Journal: Metabolism (2009)
HSP 60 expression in mucocutaneous lesions of Beh?et's disease
Authors: Tlin Ergun, mit nce, Emel Ekiolu-Demiralp, Haner Direskeneli, Oya Grbz, Leyla Grses, Fgen Aker, Tevfik Akolu
Journal: Journal of the American Academy of Dermatology (2001)
Timing of birth and risk of multiple sclerosis: population based study
Authors: Cristen J Willer, David A Dyment, A Dessa Sadovnick, Peter M Rothwell, T Jock Murray, George C Ebers
Journal: BMJ (2004)

<h3>Abstract</h3> <b>Objectives</b> To determine if risk of multiple sclerosis (MS) is associated with month of birth in countries in the northern hemisphere and if factors related to month of birth interact with genetic risk. <b>Design</b> Population based study with population and family based controls and a retrospective cohort identified from death certificates. A post hoc pooled analysis was carried out for large northern datasets including Sweden and Denmark. <b>Setting</b> 19 MS clinics in major cities across Canada (Canadian collaborative project on the genetic susceptibility to multiple sclerosis); incident cases of MS from a population based study in the Lothian and Border regions of Scotland; and death records from the UK Registrar General. <b>Populations</b> 17 874 Canadian patients and 11 502 British patients with multiple sclerosis. <b>Main outcome measure</b> Diagnosis of multiple sclerosis. <b>Results</b> In Canada (n = 17 874) significantly fewer patients with MS were born in November compared with controls from the population census and unaffected siblings. These observations were confirmed in a dataset of British patients (n = 11 502), in which there was also an increase in the number of births in May. A pooled analysis of datasets from Canada, Great Britain, Denmark, and Sweden (n = 42 045) showed that significantly fewer (8.5%) people with MS were born in November and significantly more (9.1%) were born in May. For recent incident data, the effect of month of birth was most evident in Scotland, where MS prevalence is the highest. <b>Conclusions</b> Month of birth and risk of MS are associated, more so in familial cases, implying interactions between genes and environment that are related to climate. Such interactions may act during gestation or shortly after birth in individuals born in the northern countries studied.
How Physicians Communicate about Advance Directives
Authors: Jean R. Pascoe
Journal: Annals of Internal Medicine (1999)

Letters4 May 1999How Physicians Communicate about Advance DirectivesJean R. Pascoe, MDJean R. Pascoe, MDSouthboro, MA 01772 (Pascoe)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-9-199905040-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Tulsky and colleagues (1) hit the nail on the head twice in their discussion of how physicians communicate with patients about advance directives. They rightly state that little time is left in any appointment for these discussions and point out that it is extremely difficult to plan in advance for situations that are complex and involve high levels of uncertainty. It was disappointing, therefore, that they concluded that the poor quality of these discussions can be improved by teaching practitioners improved communication skills. Their study does not even address this hypothesis, and I submit that it is ...Reference1. Tulsky JA, Fischer GS, Rose MR, Arnold RM. Opening the black box: how do physicians communicate about advance directives? Ann Intern Med. 1998;129:441-9. LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Jean R. Pascoe, MDAffiliations: Southboro, MA 01772 (Pascoe) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoOpening the Black Box: How Do Physicians Communicate about Advance Directives? James A. Tulsky , Gary S. Fischer , Mary R. Rose , and Robert M. Arnold How Physicians Communicate about Advance Directives James A. Tulsky , Gary S. Fischer , and Robert M. Arnold How Physicians Communicate about Advance Directives Bruce Leff Metrics 4 May 1999Volume 130, Issue 9Page: 781 ePublished: 15 August 2000 Issue Published: 4 May 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Acquired Immunodeficiency Syndrome and Biliary Tract Disease
Authors: ALFRED E. STILLMAN
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 April 1987Acquired Immunodeficiency Syndrome and Biliary Tract DiseaseALFRED E. STILLMAN, M.D., ROGER SCHMID, M.D., JEFFREY B. HOWE, M.D.ALFRED E. STILLMAN, M.D.Search for more papers by this author, ROGER SCHMID, M.D.Search for more papers by this author, JEFFREY B. HOWE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-4-634_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Margulis and coauthors (1) reported three patients with the acquired immunodeficiency syndrome (AIDS) and biliary tract disease resembling sclerosing cholangitis. The three patients presented with fever and diarrhea; two had right upper quadrant pain. All had alkaline phosphatase elevations ranging from 8 to 30 times the upper limit of normal. One patient hadCryptosporidiumoocysts in his bile and in his surgically removed gallbladder. Another patient had cytomegalovirus inclusions in gallbladder and biliary duct epithelium and muscularis. The third patient had both cryptosporidia and cytomegalovirus mucosal inclusions at the ampulla of Vater. A fourth patient mentioned in...References1. MARGULIS S, HONIG C, SOAVE R, GOVONI A, MOURADIAN J, and JACOBSON I. Biliary tract obstruction in the acquired immune deficiency syndrome. Ann Intern Med. 1986;105:207-10. LinkGoogle Scholar2. CHAPMAN R, BURROUGHS A, BASS N, and SHERLOCK S. Long-standing asymptomatic primary sclerosing cholangitis. Dig Dis Sci. 1981;26:778-82. CrossrefMedlineGoogle Scholar3. LARUSSO N, WIESNER R, LUDWIG J, and MACCARTY R. Primary sclerosing cholangitis. N Engl J Med. 1984;310:899-903. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALFRED E. STILLMAN, M.D.; ROGER SCHMID, M.D.; JEFFREY B. HOWE, M.D.Affiliations: Medical Arts Building Suite 203, 100 South Street; Southbridge, MA 01550 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProtozoal and Helminthic Diseases of the Liver and Biliary TractChronic sclerosing cholangitis and recurrent pulmonary infections in two brothers associated with cellular immunodeficiency and increased cytokine productionNecropsy Findings in Rhesus Monkeys Experimentally Infected with Cultured Simian Immunodeficiency Virus (SIV)/DeltaAbdominal Pain and Anorectal Disease in AIDS 1 April 1987Volume 106, Issue 4Page: 634-634KeywordsAIDSBiliary systemDiarrheaEpitheliumFeversGallbladderOocystsPatient advocacyPhosphatasesPrimary sclerosing cholangitis ePublished: 1 December 2008 Issue Published: 1 April 1987 PDF downloadLoading ...
Commentary: A decision that stretches the law too far
Authors: A. Whitfield
Journal: BMJ (1997)

The decision of Tameside and Glossop Acute Services Trust v CH,1 heavily criticised by academic writing,2 represents a further development of the law relating to “enforced” caesarean sections. It is important to distinguish this case, which was decided under section 63 of the Mental Health Act (1983), from cases decided under the common law. Now the basic principles of the common law are reasonably clear:
Priapism in a non‐black with sickle cell anemia associated with α‐thalassemia
Authors: Alexander Fich, Eliezer A. Rachmilewitz
Journal: American Journal of Hematology (1981)

Abstract Sickle cell anemia, the most prevalent type of hemoglobinopathy, appears almost exclusively in blacks. Since the first report of sickle cell anemia in a Caucasian by Cooley and Lee in 1929 [1], additional cases have been reported, mainly from Mediterranean countries, the Persian Gulf, and India [2]. Several cases were also found among Arabs in Israel with a relatively benign clinical course [3, 4]. The present report describes a unique case of sickle cell anemia associated with α‐thalassemia in a non‐black young adult. The diagnosis was made at the age of 23 years. Severe priapism was almost the first manifestation of the disease and subsided following transfusion of five units of packed red blood cells.
Letter: Jaundice after halothane.
Authors: J Dundee, R C Gray
Journal: BMJ (1974)

<h3>BACKGROUND AND PURPOSE:</h3> Spinocerebellar ataxia type 7 is an autosomal dominant neurodegenerative disease caused by a cytosine-adenine-guanine (CAG) repeat expansion. Clinically, spinocerebellar ataxia type 7 is characterized by progressive cerebellar ataxia, pyramidal signs, and macular degeneration. In vivo MR imaging studies have shown extensive gray matter degeneration in the cerebellum and, to a lesser extent, in a range of cortical cerebral areas. The purpose of this study was to evaluate the impact of the disease in the spinal cord and its relationship with the patient9s impairment. <h3>MATERIALS AND METHODS:</h3> Using a semiautomated procedure applied to MR imaging data, we analyzed spinal cord area and eccentricity in a cohort of 48 patients with spinocerebellar ataxia type 7 and compared them with matched healthy controls. The motor impairment in the patient group was evaluated using the Scale for Assessment and Rating of Ataxia. <h3>RESULTS:</h3> Our analysis showed a significantly smaller cord area (<i>t</i> = 9.04, <i>P</i> &lt; .001, <i>d</i> = 1.31) and greater eccentricity (<i>t</i> = –2.25, <i>P</i> =. 02, <i>d</i> = 0.32) in the patient group. Similarly, smaller cord area was significantly correlated with a greater Scale for Assessment and Rating of Ataxia score (<i>r</i> = –0.44, <i>P </i>= .001). A multiple regression model showed that the spinal cord area was strongly associated with longer CAG repetition expansions (<i>P </i>= .002) and greater disease duration (<i>P </i>= .020). <h3>CONCLUSIONS:</h3> Our findings indicate that cervical spinal cord changes are progressive and clinically relevant features of spinocerebellar ataxia type 7, and future investigation of these measures as candidate biomarkers is warranted.
Experimental evaluation of photocrosslinkable chitosan hydrogel as injection solution for endoscopic resection
Authors: T. Ishizuka, M. Ishihara, S. Aiko, Y. Nogami, S. Nakamura, Y. Kanatani, S. Kishimoto, H. Hattori, T. Horio, Y. Tanaka, T. Maehara
Journal: Endoscopy (2009)

See also: Commentaire de travail de T. Ishizuka et al., pp. 25Endoscopy 2009; 41(01): 95-95DOI: 10.1055/s-0032-1306723