Estimating Overdiagnosis of Lung Cancer
Authors: Patrick Maisonneuve, Giulia Veronesi, Raffaella Bertolotti
Journal: Annals of Internal Medicine (2013)

Letters16 April 2013Estimating Overdiagnosis of Lung CancerPatrick Maisonneuve, DipEng, Giulia Veronesi, MD, and Raffaella Bertolotti, MScPatrick Maisonneuve, DipEngFrom European Institute of Oncology, Milan, Italy., Giulia Veronesi, MDFrom European Institute of Oncology, Milan, Italy., and Raffaella Bertolotti, MScFrom European Institute of Oncology, Milan, Italy.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-158-8-201304160-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Dr. Young and Ms. Hopkins for their thoughtful comments and agree that current lung cancer risk prediction models and screening protocols should be improved to minimize the investigation and treatment of indolent cancer detected through CT screening. They provided some evidence that spirometry-defined COPD could help to differentiate between aggressive and slow-growing lung cancer.For affirmation, we retrieved preoperative spirometry measurements for 107 of the 120 cases of incident lung cancer detected during the first 5 years of the COSMOS (Continuous Observation of Smoking Subjects) study (1). For 10 patients operated on in other institutions or ...References1. Veronesi G, Maisonneuve P, Bellomi M, Rampinelli C, Durli I, Bertolotti R, et al. Estimating overdiagnosis in low-dose computed tomography screening for lung cancer: a cohort study. Ann Intern Med. 2012;157:776-84. [PMID: 23208167] LinkGoogle Scholar2. Maisonneuve P, Bagnardi V, Bellomi M, Spaggiari L, Pelosi G, Rampinelli C, et al. Lung cancer risk prediction to select smokers for screening CT—a model based on the Italian COSMOS trial. Cancer Prev Res (Phila). 2011;4:1778-89. [PMID: 21813406] CrossrefMedlineGoogle Scholar3. Jaklitsch MT, Jacobson FL, Austin JH, Field JK, Jett JR, Keshavjee S, et al. The American Association for Thoracic Surgery guidelines for lung cancer screening using low-dose computed tomography scans for lung cancer survivors and other high-risk groups. J Thorac Cardiovasc Surg. 2012;144:33-8. [PMID: 22710039] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From European Institute of Oncology, Milan, Italy.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M12-1606. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEstimating Overdiagnosis in Low-Dose Computed Tomography Screening for Lung Cancer Giulia Veronesi , Patrick Maisonneuve , Massimo Bellomi , Cristiano Rampinelli , Iara Durli , Raffaella Bertolotti , and Lorenzo Spaggiari Estimating Overdiagnosis of Lung Cancer Robert P. Young and Raewyn J. Hopkins Metrics Cited ByAirflow Limitation and Histology Shift in the National Lung Screening Trial. The NLST-ACRIN Cohort Substudy 16 April 2013Volume 158, Issue 8Page: 635-636KeywordsCancer treatmentComputed axial tomographyEmphysemaLung and intrathoracic tumorsLung cancer screeningLungsRadiologistsRespiratory system proceduresSpirometry ePublished: 16 April 2013 Issue Published: 16 April 2013 CopyrightCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...