tbuckley/cabot-search huggingface dataset:
Serum fructosamine concentration as measure of blood glucose control in insulin dependent diabetes
Authors: J. Baker
Journal: BMJ (1985)

to exaggerate the "r" and "p" values by selective exclusion of certain subjects or in- corporating non-diabetics in their statistical calculations.The fact that six diabetic sub- jects with normal HbA,, had high fructosamine values emphasises the inherent differences between the two populations.
Vagal influence in gastric acid secretion in normals and in duodenal ulcer patients.
Authors: H Singh, R K Goyal, D S Ahluwalia, H K Chuttani
Journal: Gut (1968)

The nature of hypersecretion of gastric acid in duodenal ulcer subjects remains controversial.The duodenal ulcer patients, on an average, secrete more than twice the amount of acid secreted by normal persons.It is now known that the duodenal ulcer patients have an increased parietal cell population in the stomach.Whether this increased acid output is solely due to the increased parietal cell mass is uncertain.Dragstedt and his group has been actively propagating their view of 'vagal hypertonicity' in these patients for more than 20 years (Dragstedt, Harper, Tovee, and Woodward, 1947; Dragstedt, 1967).Grossman has, on the other hand, remained unconvinced of Dragstedt's arguments (Grossman, 1949; Grossman, 1967).Hunt and Kay (1954) and Card, Sircus, Kay, and Hunt (1962) have pleaded against the existence of a supranormal drive on the parietal cells in duodenal ulcer patients, whereas Baron (1963) has suggested that about half the duodenal ulcer patients have a supranormal drive to explain their basal hypersecretion.If duodenal ulcer patients do have vagal hyper- tonicity, blocking the vagal influence should reduce the gastric acid output to a greater degree in ulcer patients than in the normal person.There are many studies on the influence ofvagal transection (Waddell, 1957;
Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A
Authors: Ingrid Hrachovinová, Beatrice Cambien, Ali Hafezi-Moghadam, János Kappelmayer, Raymond T Camphausen, Angela Widom, Lijun Xia, Haig H Kazazian, Robert G Schaub, Rodger P McEver, Denisa D Wagner
Journal: Nature Medicine (2003)
Susceptibility of people with long term illness to depression and anxiety is not recognised, report says
Authors: N. Hawkes
Journal: BMJ (2012)

A failure to recognise that people with long term conditions are often also depressed and anxious makes for poorer outcomes and substantially increases the cost of caring for them, say the healthcare think tank the King’s Fund and the independent Centre for Mental Health in a new report.

People with diabetes, heart disease, arthritis, and chronic obstructive pulmonary disease have a much greater chance of also having mental health problems that worsen their prognosis. Yet the “silo based care” offered by the NHS means that these mental health problems often go untreated or even unrecognised, the report says.

The results are damaging and expensive, it says. For example, depression increases mortality after a heart …
Cell proliferation in the liver and thyroid of C57Bl/10J mice after dietary administration of chlordane.
Authors: N Barrass, M Stewart, S Warburton, J Aitchison, D Jackson, P Wadsworth, A Marsden, T Orton
Journal: Environmental Health Perspectives (1993)

Chlordane is a polychlorinated hydrocarbon that causes liver enlargement and induces mixed-function oxidases similar to those induced by phenobarbitone in the mouse. We have assessed the hepatocarcinogenicity (after 2 years) and the time course (over 6 months) of liver and thyroid cell proliferation in C57Bl/10J mice exposed to chlordane at 50 ppm in the diet, using the same batch of food for both carcinogenicity and cell proliferation studies. In the bioassay, 15/39 survivors had hepatocellular adenomas and a further 5/59 had carcinomas, compared with less than 5% incidence of primary hepatic tumors in concurrent controls. Among unscheduled deaths, 1/40 adenomas and 2/40 carcinomas were recorded. There were no macroscopically observed thyroid lesions. In the proliferation study, mice were killed on days 4, 5, 8, 15, 29, 99, and 190 after the start of dosing. Withdrawal groups were included from days 29 to 99 and from days 190 to 247. Replicating cells were labeled via bromodeoxyuridine delivered by osmotic minipump for 3 days before necropsy. In the thyroid, the peak labeling index (LI) was seen on day 5 (LI = 5.99 +/- 2.90% versus 1.00 +/- 20% in controls), while in the liver the peak was on day 8 (9.0 +/- 1.6% versus 0.5 +/- 0.4% in controls). Both organs had an elevated LI for the first month of dosing, but while the thyroid follicular LI was similar to control at 99 and 190 days, the liver LI was significantly elevated at all time points except in the withdrawal groups.(ABSTRACT TRUNCATED AT 250 WORDS)
A New York Neurosurgeon Turns To 'Multi-Modality Therapy' To Treat Brain Cancer
Authors: F. X. Mahaney
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article A New York Neurosurgeon Turns To ‘Multi-Modality Therapy’ To Treat Brain Cancer Get access Francis X. Mahaney, Jr. Francis X. Mahaney, Jr. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 11, 6 June 1990, Pages 900–901, https://doi.org/10.1093/jnci/82.11.900 Published: 06 June 1990
Access to Primary Care in England—Reply
Authors: Brendan Saloner, Karin V. Rhodes, Daniel Polsky
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Percutaneous revascularization of the internal mammary artery graft: short- and long-term outcomes
Authors: Luis Gruberg, George Dangas, Roxana Mehran, Mun K Hong, Ron Waksman, Gary S Mintz, Kenneth M Kent, Augusto D Pichard, Lowell F Satler, Alexandra J Lansky, Gregg W Stone, Martin B Leon
Journal: Journal of the American College of Cardiology (2000)
A CASE OF EXOPHTHALMOS IN AN INFANT OF THREE MONTHS.Read in the Section on Diseases of Children, at the Forty-fifth Annual Meeting of the American Medical Association, held in San Francisco. June 5-8, 1894.
Authors: HARRIET E. GARRISON
Journal: JAMA (1894)

The patient whose case forms the basis of this article, is the elder of twin boys, born June 30, 1893. This was the mother's third confinement. The labor was normal. The delivery of No. 1 was retarded by vertex presentation. He preceded his brother by forty minutes, weighed eight pounds, and No. 2 weighed nine pounds. No. 1 cried lustily and to all appearances was as strong and vigorous as No. 2. He was warmly wrapped in flannel and placed on his right side. After the third stage of labor was completed, and the mother was made comfortable, as I had but the assistance of an untrained nurse I looked after the children. I found the nurse bathing No. 2, and No. 1 lying as he had been placed at birth, but he had become blue and the extremities cold. In an hour's time by the application of dry heat
Aspirin Exposure Reveals Novel Genes Associated With Platelet Function and Cardiovascular Events
Authors: Deepak Voora, Derek Cyr, Joseph Lucas, Jen-Tsan Chi, Jennifer Dungan, Timothy A. McCaffrey, Richard Katz, L. Kristin Newby, William E. Kraus, Richard C. Becker, Thomas L. Ortel, Geoffrey S. Ginsburg
Journal: Journal of the American College of Cardiology (2013)
Thunderstorms and Asthma
Authors: Joan Stephenson
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Updating the Model for Psychotherapy of Psychosomatic Problems
Authors: Sanford I. Cohen
Journal: Psychotherapy and Psychosomatics (1979)

There is a pressing need to broaden the base of the therapeutic efforts used to treat psychosomatic and stress induced disorders. Before this can be accomplished, it is necessary to accept the heterogeneity of the disorders which carry the same label. Psychosomatic phenomena must be clearly defined so that specific treatment goals can be formulated for the various treatment modalities which are available, e.g., modifying patterns of communication and of human relationships; altering expressive and instrumental behavior patterns; broadening of an individual’s perception of the external world and internal experiences; changing the internal state through feedback, drugs, relaxation; modifying mal-adaptive behavioral or psychopshysiological response patterns with conditioning techniques. The range of symptoms which can be defined as psychosomatic include: (1) Symptoms referable to the body which are the expression of ideas, thoughts, or feelings and are not related to altered physiology (conversion, depressive, hypochondriac or body delusional symptoms). (2) Specific physiological changes which accompany psychological states (anxiety, anger, vigilance). (3) Symptoms of organic disease which lead to secondary psychological reactions (somato psychic). (4) Symptoms of diseases whose onset is related to the loss of significant objects and the feeling of hopelessness and helplessness. In order to integrate relevant developmental, psychodynamic, social stress and biological data in relation to illness, a new biopsychosocial model is needed. <i>Engel</i> (11), <i>Weiner</i> (40), <i>Nemiah</i> and <i>Sifenos</i> (29), <i>Sandler</i> (34), <i>Mason</i> (25), <i>Bahnson</i> (6), <i>Luria</i> (22) and <i>Miller</i> (26) have all suggested comprehensive psychobiological etiologic models. These models should be useful in establishing the methods and goals of a more scientific psychobiologically based therapy for psychosomatic disorders.
Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1–deregulated expression
Authors: Ying Zhang, Yuka Nagata, Guangyao Yu, Hao G. Nguyen, Matthew R. Jones, Paul Toselli, Carl W. Jackson, Masaaki Tatsuka, Kazuo Todokoro, Katya Ravid
Journal: Blood (2004)
Comment: Cancer Epidemiology
Authors: Philip Rubin
Journal: JAMA (1973)

The contribution to understanding the pathogenesis of cancer by current epidemiologic studies is well illustrated by the evolving literature in alimentary tract tumors. Epidemiologic techniques study the distribution of cancer and seek to uncover its determining factors; they are concerned with the search for clues of excessive prevalence of a disease. The application of epidemiologic methods to noninfectious diseases like cancer has provided a new system of investigation for uncovering the relationship of human cancer to man's environment. The ultimate goal is to understand the causal mechanisms that form a basis for preventive measures. In order to establish a causal association between diseases and environmental exposure, a rate of occurrence or disease frequency (tumor incidence) must be determined. "Incidence" has acquired a precise meaning in epidemiologic usage during the past decade; it means the number of new cases observed in a certain time period and in a specified population of
Geographical Variation in Leukaemia Mortality in Relation to Background Radiation and Other Factors
Authors: W. M. C. Brown, R. Doll, F. W. Spiers, B. J. Duffy, M. J. McHugh
Journal: BMJ (1960)

rhere is no doubt that the risk of developing leukaemia can be increased by exposure to ionizing radiations.but it is not clear whether this effect is produced by all types of exposure or whether it is limited to certain levels of dose and of dose-rate.Cases have been produced by exposure of the whole body to doses of y rays of the order of 100 to 500 rads given within a few seconds as a result of the explosion of atomic bombs (Folley,
Idiopathic carpal tunnel syndrome caused by carpal stenosis.
Authors: S Dekel, T Papaioannou, G Rushworth, R Coates
Journal: BMJ (1980)

Computed tomography was used to measure the cross-sectional area of the carpal canals in normal controls of both sexes and in women with idiopathic carpal tunnel syndrome. The women controls had significantly smaller carpal canals than the men controls both proximally and distally. In the patients both the proximal and distal cross-sectional areas were significantly reduced compared with the women controls. The measurements showed that carpal canal stenosis is associated with idiopathic carpal tunnel syndrome, narrowing of the canal is bilateral in patients who have unilateral symptoms, and narrowing is greater in the proximal carpal canal. There was no correlation between age and the size of the canal. The difference in the size of the carpal canal between normal men and women might explain the tendency of women to develop carpal tunnel syndrome. The lack of correlation between age and the size of the canal suggests that stenosis of the carpal canal is inherited rather than acquired. Symptoms arise only later in life, when degenerated changes in the content or the walls of the carpal canal compete with the median nerve for space and its function becomes impaired by compression.
Invasion: Experimental and Clinical Implications
Authors: Jacob D. Bitran
Journal: JAMA (1986)

Five years ago, I had the opportunity to review the mechanism of metastasis in volume 4 of the text<i>Metastasis</i>, edited by Weiss and Gilbert; this was a superior and informative text on the mechanisms of cancer invasion and metastases. Unfortunately, the text by Mareel and Calman is shorter in scope and content than the Weiss and Gilbert text. The editors state in the preface "it is hoped that this book will summarize some of the current ideas in regard to metastasis and will stimulate further research needs in this area." I agree that further research is required; however, this text does not summarize sufficiently an important aspect of metastasis, namely, invasion. This is not to say that all the chapters are of average quality. There are some well-written and informative ones by Hart, Carter, Sterauli, and Easty. The references are relatively up-to-date, most being from 1982 with an occasional
Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract.
Authors: R M Housley, C F Morris, W Boyle, B Ring, R Biltz, J E Tarpley, S L Aukerman, P L Devine, R H Whitehead, G F Pierce
Journal: Journal of Clinical Investigation (1994)

Keratinocyte growth factor (KGF), a member of the fibroblast growth factor (FGF) family, was identified as a specific keratinocyte mitogen after isolation from a lung fibroblast line. Recently, recombinant (r)KGF was found to influence proliferation and differentiation patterns of multiple epithelial cell lineages within skin, lung, and the reproductive tract. In the present study, we designed experiments to identify additional target tissues, and focused on the rat gastrointestinal (GI) system, since a putative receptor, K-sam, was originally identified in a gastric carcinoma. Expression of KGF receptor and KGF mRNA was detected within the entire GI tract, suggesting the gut both synthesized and responded to KGF. Therefore, rKGF was administered to adult rats and was found to induce markedly increased proliferation of epithelial cells from the foregut to the colon, and of hepatocytes, one day after systemic treatment. Daily treatment resulted in the marked selective induction of mucin-producing cell lineages throughout the GI tract in a dose-dependent fashion. Other cell lineages were either unaffected (e.g., Paneth cells), or relatively decreased (e.g., parietal cells, enterocytes) in rKGF-treated rats. The direct effect of rKGF was confirmed by demonstrating markedly increased carcinoembryonic antigen production in a human colon carcinoma cell line, LIM1899. Serum levels of albumin were specifically and significantly elevated after daily treatment. These results demonstrate rKGF can induce epithelial cell activation throughout the GI tract and liver. Further, endogenous KGF may be a normal paracrine mediator of growth within the gut.
The Doctor's Case Against the Pill
Authors: Carl J. Levinson
Journal: JAMA (1996)

This is a strange book and not particularly recommended. It represents a 25th anniversary republication, introduced by a new foreword and eight pages on "The Story Behind This Book." An editor's note indicates that "the text on pages 9-211 comprises the entire original edition of<i>The Doctor's Case Against the Pill</i>, first published in 1969." One would hope to find an illuminating update in "The Pill at 35" (pages 212-238) and "Norplant, the Contraceptive You're Stuck With" (pages 239-252). To be quite fair, one must read the original edition in the light of its times, the 1960s: the dosages of hormones in oral contraceptives were high, and the oral contraceptives had been widely used for only five to ten years. Ms Seaman had taken a strong view that problems with the pill were being ignored. (I found it odd that the first page of the original edition, "A Public Scandal
Purification of CD45+ hematopoietic cells directly from human bone marrow using a flow‐based P‐selectin‐coated microtube
Authors: Srinivas D. Narasipura, Joel C. Wojciechowski, Brian M. Duffy, Jane L. Liesveld, Michael R. King
Journal: American Journal of Hematology (2008)

Abstract Recently, a flow‐based selectin‐dependent method for capture and enrichment of specific type blood cells (CD34+ hematopoietic stem and progenitor cells) from bone marrow and peripheral blood has been described. Using a similar approach, here we show isolation of CD45+ blood cells directly from human bone marrow to a high purity (90%–97%). The process mimics a ubiquitous mechanism of cell trafficking in the body for the recruitment of neutrophils during inflammation. The method is straightforward, rapid, and may represent a practical alternative to CD45+ cell enrichment procedures required for chimerism analysis following allogenic stem‐cell transplantation. Am. J. Hematol., 2008. © 2008 Wiley‐Liss, Inc.
Breast Abscess and Staphylococcal Disease in a Maternity Hospital
Authors: V. D. Plueckhahn, J. Banks
Journal: BMJ (1964)

This report concerns the occurrence of breast abscess in 18,275 mothers delivered in the 95-bed maternity unit of the Geelong and District Hospital between July 1956 and December 1963.A reduction in the incidence of puerperal breast abscess from 2.5% to 0.16% of mothers delivered during this time is reported and factors responsible are discussed.Geelong is a rural industrial city of approximately 100,000 inhabitants.The city and surrounding district are well defined and depend on the Geelong and District Hospital for all maternity beds and more than 90% of general-hospital beds.This centralization of medical services greatly facilitated an almost complete follow-up investigation of mothers and babies for a period of six months after delivery.In addition, all medical practitioners in the area co-operated fully in this survey by making their private records available and completing questionaries circulated to them at three-monthly intervals.Further information was gained by checking private and public hospital records, the records of infant health centres, and by personal contact of mothers after discharge home by visits, telephone, or posted questionaries.The term " puerperal breast abscess " is used to denote any inflammatory condition, of either breast, which occurred within six months of delivery, and which resulted in suppuration or required incision.Staphylococcal skin disease includes pustules, paronychia, abscesses, rashes, and any other skin lesions from which staphylococci were grown on culture.Minimal observer variation has occurred during the survey.All aspects have been continually supervised by one or other of us.Three of the four floors in the maternity wing have had the same sister-in-charge throughout the survey.Many other aspects of this study, including basic nursery techniques and bacteriological methods used, have been reported in previous papers (Plueckhahn, 1961; Plueckhahn and Banks, 1958, 1961, 1963).Any reference to the staphylococcus refers to a coagulase-positive Staphylococcus aureus unless otherwise stated. ResultsThe results of certain aspects of this survey are shown in Tables I to XII.Breast Abscess-Type and Bacterial Agent Responsible.-TableI records the total number of breast abscesses occurring in Geelong from 1 July 1956 to 31 December 1963.It shows that 96% of these abscesses were directly related to pregnancy and that a coagulase-positive Staph.aureus was the bacterial agent responsible in every breast abscess from which material was available for culture.Puerperal Breast Abscess-Incidence in 18,275 Mothers Delivered during 7uly 1956 to December 1963.-TableII shows the incidence and number of breast abscesses developing each year.The corresponding yearly incidence of staphylococcal skin disease in infants up to 10 days old is also shown.The marked reduction in infant staphylococcal skin disease and the corresponding decrease in puerperal breast abscess occurring during the survey is clearly shown in Table II.
Aspergillus meningitis: A rare clinical manifestation of central nervous system aspergillosis. Case report and review of 92 cases
Authors: Spinello Antinori, Mario Corbellino, Luca Meroni, Federico Resta, Salvatore Sollima, Massimo Tonolini, Anna Maria Tortorano, Laura Milazzo, Lorenzo Bello, Elisa Furfaro, Massimo Galli, Claudio Viscoli
Journal: Journal of Infection (2012)