tbuckley/cabot-search huggingface dataset:
Report Shows E-Cigarette Marketing Aimed at Youth
Authors: Anita Slomski
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High-dose cytosine arabinoside and daunorubicin induction therapy for adult patients with de novo non M3 acute myelogenous leukemia: impact of cytogenetics on achieving a complete remission
Authors: AS Stein, MR O'Donnell, ML Slovak, A Nademanee, A Dagis, GM Schmidt, PM Parker, DS Snyder, EP Smith, G Somlo, KA Margolin, D Arber, J Niland, SJ Forman
Journal: Leukemia (2000)
The contribution of transcription factor IRF1 to the interferon-γ–interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells
Authors: Shin-ichi Kano, Kojiro Sato, Yasuyuki Morishita, Sabine Vollstedt, Sunhwa Kim, Keith Bishop, Kenya Honda, Masato Kubo, Tadatsugu Taniguchi
Journal: Nature Immunology (2007)
Medical Forgeries—the Hagen Burger Case.
Authors: S. D. Van Meter
Journal: JAMA (1906)

Denver, Feb. 19,1906. <h3>To the Editor:</h3> —Dr. J. C. Connell's letter inThe Journal, February 17, contains certain misleading statements relative to the now famous Hagen Burger case that I can not allow to go without correction. By reference to my article on "Medical Forgeries" inThe Journal, February 3, it will be seen that in the second paragraph of his letter he has misquoted the sentence relative to the power of revocation vested in the Colorado licensing board. He has changed the past tense of the verb<i>to have</i>to the present. In criticising the board's failure to convict Hagen Burger of the criminal charge still pending against him, as compared with the inability, thus far, of the Queen's University senate to revoke the diploma which they know was secured on fraudulent representation, Dr. Connell fails to take into consideration the greater difficulty one encounters in securing a conviction
Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation.
Authors: R J Parker, A Eastman, F Bostick-Bruton, E Reed
Journal: Journal of Clinical Investigation (1991)

Studies were undertaken to investigate acquired resistance to cisplatin in human ovarian cancer cells. The cell lines A2780 and A2780/CP70 were studied to assess their respective characteristics of drug accumulation and efflux, cytosolic inactivation of drug, and DNA repair. All experiments were performed using 1-h drug exposures. The A2780/CP70 cell line was 13-fold more resistant to cisplatin than A2780 cells. When studied at their respective IC50 doses, drug accumulation rates were similar for the two cell lines. However, the resistant cell line was twofold more efficient at effluxing drug, which was associated with reduced total drug accumulation for equivalent micromolar drug exposures. At equivalent levels of total cellular drug accumulation, the two cell lines formed the same levels of cisplatin-DNA damage, suggesting that cytosolic inactivation of drug does not contribute to the differential in resistance between these cell lines. Resistant cells were also twofold more efficient at repairing cisplatin-DNA lesions in cellular DNA and in transfected plasmid DNA. We conclude that in these paired cell lines, alterations in drug uptake/efflux and in DNA repair are the major contributing factors to acquired resistance to cisplatin.
Results of randomized phase II trial combining Iressa® (gefitinib) and arimidex in women with advanced breast cancer (ABC). EORTC protocol 10021.
Authors: L Mauriac, D Cameron, L Dirix, E Blot, M Piccart, S Marreaud, V Tjan-Heijnen, T Cufer, J Bogaerts, G Atalay Basaran
Journal: Cancer Research (2009)

Abstract Abstract #6133 Background: Preclinical data suggest that EGFR inhibitors could overcome endocrine resistance in breast cancer. This European multicenter, double-blind, placebo-controlled trial was designed to test the hypothesis that Gefitinib (G), as inhibitor of the EGFR pathway, can delay the onset of endocrine resistance in ABC. Methods: Postmenopausal patients (pts) previously treated for ABC (including locally recurrent or metastatic or elderly with locally ABC or bone metastases only) were randomly assigned in a 1:1 ratio to G 250 mg/day plus anastrozole (A, 1 mg/day) or to placebo plus A. Prior treatment with an aromatase inhibitor in metastatic setting or trastuzumab or anti EGF or anti VEGF was not allowed. Treatment was given until progression of the disease, unacceptable toxicity or patient refusal and the progression free rate was assessed at one year with disease evaluations according to RECIST performed every 8 weeks.&amp;#x2028; Results: The trial was prematurely closed in August 2007 due to slow recruitment. Seventy one out of a planned 108 pts were entered with a median age of 64 (range 42-84). 26 pts had prior chemotherapy and 43 prior endocrine therapy (adjuvant tamoxifen 60% and metastatic 16%). Median PS was 0 and 41 pts had visceral disease. To date, 326 months of treatment have been fully documented, for a median duration of 6 months. For 36 pts end of treatment has been reported: 26 due to progression and 6 due to toxicity (including one SAE: diarrhea gr 3 and spastic dyspnea gr 2). The most common adverse events were fatigue (49%), arthralgia/myalgia (39%), nausea (37%), diarrhea (35%), rash (35%), bone pain (29%), and hot flushes (26%).To date, the estimated progression free rate at one year is 42%. Conclusion: All patients will reach one year of follow up in August 2008. The database has not been unblinded yet. By the time of the conference unblinded final results will be available. A late breaking abstract will be sent in September. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 6133.
Letter: Cyclophosphamide in treatment of nephrotic syndrome.
Authors: L S Ibels, A A Palmer, J F Mahony, J H Stewart
Journal: BMJ (1975)

1975 treated in this way.Surface abscesses were also drained when aspiration failed to clear them.We would like to emphasize these points so as to spare any disappointment to our colleagues in the tropics when they are faced, as they will be, with such situations.-We are, etc.,
Stromal Tumor Causing Small Intestinal Bleeding: Scintigraphic Localization
Authors: BELUR S. CHANDRAMOULY, DAVID W. WU
Journal: Clinical Nuclear Medicine (1999)

A radionuclide bleeding study was performed in a patient after several episodes of passage of blood per rectum. A focal area of active bleeding was noted in the distal ileum. Angiography confirmed this as the source of bleeding, and a stromal tumor of the ileum was surgically resected. The scintigraphic study accurately detected a small intestinal-bleeding site that was not suspected clinically.
Comparison of the Hemodynamic Performance of Percutaneous and Surgical Bioprostheses for the Treatment of Severe Aortic Stenosis
Authors: Marie-Annick Clavel, John G. Webb, Philippe Pibarot, Lukas Altwegg, Eric Dumont, Chris Thompson, Robert De Larochellière, Daniel Doyle, Jean-Bernard Masson, Sebastien Bergeron, Olivier F. Bertrand, Josep Rodés-Cabau
Journal: Journal of the American College of Cardiology (2009)
Feasibility of Using Subject-Collected Dust Samples in Epidemiologic and Clinical Studies of Indoor Allergens
Authors: Samuel J. Arbes, Michelle Sever, Ben Vaughn, Jigna Mehta, Jeffrey T. Lynch, Herman Mitchell, Jane A. Hoppin, Harvey L. Spencer, Dale P. Sandler, Darryl C. Zeldin
Journal: Environmental Health Perspectives (2005)

Studies of indoor allergen exposures are often limited by the cost and logistics of sending technicians to homes to collect dust. In this study we evaluated the feasibility of having subjects collect their own dust samples. The objectives were to compare allergen concentrations between subject- and technician-collected samples and to examine the sample return rate. Using a dust collection device and written instructions provided to them by mail, 102 subjects collected a combined dust sample from a bed and bedroom floor. Later the same day, a technician collected a side-by-side sample. Dust samples were weighed and analyzed for the cat allergen Fel d 1 and the dust mite allergen Der p 1. Fifty additional subjects who were enrolled by telephone were mailed dust collection packages and asked to return a dust sample and questionnaire by mail. A technician did not visit their homes. Correlations between subject- and technician-collected samples were strong for concentrations of Fel d 1 (r = 0.88) and Der p 1 (r = 0.87). With allergen concentrations dichotomized at lower limits of detection and clinically relevant thresholds, agreements between methodologies ranged from 91 to 98%. Although dust weights were correlated (r = 0.48, p < 0.001), subjects collected lighter samples. Among the group of 50 subjects, 46 returned a dust sample and completed questionnaire. The median number of days to receive a sample was 15. With some limitations, subject-collected dust sampling appears to be a valid and practical option for epidemiologic and clinical studies that report allergen concentration as a measure of exposure.
The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro.
Authors: J W Young, L Koulova, S A Soergel, E A Clark, R M Steinman, B Dupont
Journal: Journal of Clinical Investigation (1992)

T cells respond to peptide antigen in association with MHC products on antigen-presenting cells (APCs). A number of accessory or costimulatory molecules have been identified that also contribute to T cell activation. Several of the known accessory molecules are expressed by freshly isolated dendritic cells, a distinctive leukocyte that is the most potent APC for the initiation of primary T cell responses. These include ICAM-1 (CD54), LFA-3 (CD58), and class I and II MHC products. Dendritic cells also constitutively express the accessory ligand for CD28, B7/BB1, which has not been previously identified on circulating leukocytes freshly isolated from peripheral blood. Dendritic cell expression of both B7/BB1 and ICAM-1 (CD54) increases after binding to allogeneic T cells. Individual mAbs against several of the respective accessory T cell receptors, e.g., anti-CD2, anti-CD4, anti-CD11a, and anti-CD28, inhibit T cell proliferation in the dendritic cell-stimulated allogeneic mixed leukocyte reaction (MLR) by 40-70%. Combinations of these mAbs are synergistic in achieving near total inhibition. Other T cell-reactive mAbs, e.g., anti-CD5 and anti-CD45, are not inhibitory. Lymphokine secretion and blast transformation are similarly reduced when active accessory ligand-receptor interactions are blocked in the dendritic cell-stimulated allogeneic MLR. Dendritic cells are unusual in their comparably higher expression of accessory ligands, among which B7/BB1 can now be included. These are pertinent to the efficiency with which dendritic cells in small numbers elicit strong primary T cell proliferative and effector responses.
Lower cranial nerve motor function in unilateral vascular lesions of the cerebral hemisphere
Authors: R T Ross
Journal: BMJ (1984)

neurophysiological investigation alone.5 6 As the number of children in the published series has been small, these results are promising but as yet inconclusive.No serial studies of computed tomography or magnetic resonance imaging in children in coma are available.It is of great importance to those concerned with the intensive care of children that reliable predictive criteria for the development of the persistent vegetative state are established.This can be achieved only by detailed clinical, neurophysiological, and neuroradiological studies of the evolution of coma in childhood.When such coma in childhood does lead to a persistent vegetative state there are profound implications for the family, and many believe that this outcome represents a failure of intensive care medicine.
Possession Of Epinephrine Auto-Injectors (EAI) In a Vulnerable Canadian Population With Food Allergies
Authors: Sabrine Cherkaoui, Lianne Soller, Moshe Ben-Shoshan, Daniel Harrington, Sebastien La Vieille, Joseph Fragapane, Lawrence Joseph, Yvan St-Pierre, Susan Elliott, Ann Elaine Clarke
Journal: Journal of Allergy and Clinical Immunology (2014)
Increased Na+/Li+ countertransport activity may help to identify type 1 diabetic adolescents and young adults at risk for developing persistent microalbuminuria.
Authors: F Chiarelli, M Catino, S Tumini, M de Martino, A Mezzetti, A Verrotti, M Vanelli
Journal: Diabetes Care (1999)

OBJECTIVE: To evaluate whether erythrocyte sodium-lithium countertransport (Na+/Li+ CT) activity may identify adolescents and young adults with childhood-onset of type 1 diabetes to be at greater risk to develop persistent microalbuminuria and incipient diabetic nephropathy. RESEARCH DESIGN AND METHODS: In January 1989, Na+/Li+ CT was measured in 170 normoalbuminuric diabetic adolescents and young adults (age 12-23 years; onset of diabetes before age 18 years; duration of diabetes longer than 7 years). Participants were clinically examined at baseline and biennially thereafter. Na+/Li+ CT activity was measured every 2 years during the 8-year follow-up period. Na+/Li+ CT activity was measured also in parents of diabetic offspring. RESULTS: Over 8 years, 18 (10 male, 8 female) out of 170 patients (10.5%) developed persistent microalbuminuria; no patient developed overt nephropathy. The risk of developing microalbuminuria was higher in children with increased Na+/Li+ CT (using 300 mumol.1 erythrocytes-1.h-1 as the arbitrary cutoff point) (group 1) compared with those with normal Na+/Li+ CT at the beginning of the study (group 2) (18.98 vs. 3.29%, P &amp;lt; 0.01; sensitivity 96.7%; specificity 57.9%). Sex did not influence predictive value, sensitivity, or specificity. Na+/Li+ CT was not significantly correlated with HbA1c or duration of type 1 diabetes. The percentage of offspring with both parents having Na+/Li+ CT activity above the median values was significantly higher in patients in group 1 than in group 2. The odds ratio for the occurrence of microalbuminuria after adjustment for confounding variables (albumin excretion rate [AER], sex, HbA1c, mean blood pressure, cholesterol, triglycerides) in type 1 diabetic adolescents with elevated baseline erythrocyte Na+/Li+ CT was 4.5 (95% CI of 2.1-11.4). CONCLUSIONS: These results confirm those of previous studies and suggest that Na+/Li+ CT may be one of the predictors and risk factors for incipient diabetic nephropathy in adolescents and young adults with onset of diabetes during childhood. Persistently increased Na+/Li+ CT activity may help to identify normotensive, normoalbuminuric patients with type 1 diabetes who are predisposed to develop microalbuminuria and incipient diabetic nephropathy.
Advice to pregnant women to avoid eating peanuts should be withdrawn, says Lords committee
Authors: Zosia Kmietowicz
Journal: BMJ (2007)

Department of Health advice for pregnant women with a family history of atopic diseases to avoid eating peanuts and food that contains peanuts and not to give such food to their children until the age of 3 years is out of date and should be immediately withdrawn, says a report from the House of Lords.

The health department advice, which was first issued in 1998 and is repeated in government booklets given to pregnant women and new parents, is totally without evidence, the House of Lords Science and Technology Select Committee heard during its inquiry into allergy in …
An Address on some of the Anatomical Associations of the Kidneys, from a Surgical Point of View: Given before the Cardiff Medical Society, June 6th, 1901
Authors: E. Owen
Journal: BMJ (1901)

PRESIDENT AND GENTLEMEN,-If it were tlle custom for the reader of a Surgical Address to select a text before be- ginning his discourse, I should venture to remindI you that, just revious to giving his beautiful description of Charity, St. Paul boldly wandered into the fields of Anatomy and Pathology in order to obtain some striking comparative illustrations for the subject then in hand.He was speaking of the various members of the body being mutually depend- ent upon each other, and, comparing one part with another, he insisted on the absolute necessity even of those members of the body which might possibly seem at first sight to be "feeble" or "uncomely."He does not tell us to which viscera or parts he is referring, and it certainly is not for me to offer a speculative suggestion as to which he meant, but, taking up his pathological parable, I should like to express my entire agreement with nis statement that when one mean- ber suffers the other members suffer with it.Such a comprehensive affirmation offers abundant material for thought for a half-educated medical man who sets out to occupy hinself in working a linear speciality, and for the complaisant gentleman whose practice is, for the most part, based upon the shifting sands of symptoms.Yes; and also for the physician or surgeon with views as wide, may be, as the horizon-who rightly hesitates to prescribe for a patient until he has established his diagnosis upon the very rock-bed itself, or upon what he takes to be the rock-bed-which, how- ever, is not always the same thing.NERVE ASSOCIATIONS OF THE KIDNEYS.In a large proportion of cases of renal disease the most prominent symptom is the subjective one of pain.At any rate, it is usually this which brings the patient to the surgeon, and makes the latter set to work to discover objective signs which may lead him to a correct conclusion as regards its cause.In speaking of the anatomical associations of the kidney, therefore, early and prominent attention must be paid to the nerves, which not only associate the kidney with the neighbouring parts, but also keep the kidneys in har- monious working with each other.The nerves are derived from the sympathetic plexus in front of the upper part of the abdominal aorta, and into this plexus run branches of the splanchnics, the pneumogastrics, and also, indirectly, of the spinal nerves.These various filaments join in an entanglement from which the finost instruments of the most skilled dissector are unable to sort or unravel them, and each abdominal viscus takes filaments from this interlacement according to its needs.
Changes in the distribution of hepatitis C virus (HCV) genotypes over time in Spain according to HIV serostatus: Implications for HCV therapy in HCV/HIV-coinfected patients
Authors: Belén Ramos, Marina Núñez, Carlos Toro, Julie Sheldon, Javier García-Samaniego, Pilar Ríos, Vincent Soriano
Journal: Journal of Infection (2006)
Doppler echocardiographic quantitation of cross-sectional area under various hemodynamic conditions: An experimental validation in a canine model of supravalvular aortic stenosis
Authors: Akira Kitabatake, Kenshi Fujii, Jun Tanouchi, Ken Ishihara, Masaaki Uetmatsu, Tohru Masuyama, Yutaka Yoshida, Masatsugu Hori, Takenobu Kamada
Journal: Journal of the American College of Cardiology (1990)
Shifts in the concentrations of magnesium and calcium in early porcine and rat wound fluids activate the cell migratory response.
Authors: J J Grzesiak, M D Pierschbacher
Journal: Journal of Clinical Investigation (1995)

Accruing evidence indicates that the levels of extracellular Mg2+ and Ca2+ can have a distinct impact on the adhesive and migratory activities of many cell types. The physiological relevance of these observations, however, has remained largely unexplored. In the present study, wound fluids collected throughout the early stages of cutaneous wound repair were examined for possible Mg2+ and Ca2+ fluctuations. Early in the process, when cell migration into the wound site is initiated, Mg2+ is elevated and Ca2+ is reduced (Mg2+:Ca2+ = 1). As wound healing progresses, wound fluid concentrations of Mg2+ and Ca2+ begin to return to normal plasma levels (Mg2+:Ca2+ = 0.4). When macrophages, keratinocytes, fibroblasts, and endothelial cells were exposed to dialyzed wound fluid, the migration stimulated by undialyzed wound fluid was lost. Addition back to dialyzed wound fluid of 24 h, postinjury concentrations of Mg2+ and Ca2+ restored all migratory stimulus. This observed migration is approximately twofold greater than when normal plasma Mg2+ and Ca2+ concentrations are present. Changes in the levels of Mg2+ and Ca2+ in wound fluid occur during the same period that inflammatory cells, keratinocytes, fibroblasts, and neovasculature have been shown to migrate during wound healing in vivo. Together, these data suggest that the impact of these changes on integrins and E-cadherin may play a direct role in the activation and maintenance of the migratory phenotypes of the cells involved in the wound healing process.
Introduction: what are the issues in addressing the allergenic potential of genetically modified foods?
Authors: Dean D Metcalfe
Journal: Environmental Health Perspectives (2002)

There is growing concern among the general public and the scientific community regarding the potential toxicity of genetically modified organisms (GMOs). The use of biotechnology to enhance pest resistance or nutritional value has raised a number of fundamental questions including the consequences of insertion of reporter genes, the spread of resistance genes to surrounding plants, and the use of suicide genes to prohibit reuse of seed from engineered plants. Of particular interest is the ability of proteins from GMOs to elicit potentially harmful immunologic responses, including allergic hypersensitivity. The lack of information of the potential toxicity of these products suggests a need to identify the critical issues and research needs regarding these materials and to develop testing strategies to examine the allergenicity of these compounds.
Toxoplasma Profilin Is Essential for Host Cell Invasion and TLR11-Dependent Induction of an Interleukin-12 Response
Authors: Fabienne Plattner, Felix Yarovinsky, Stephane Romero, Dominique Didry, Marie-France Carlier, Alan Sher, Dominique Soldati-Favre
Journal: Cell Host & Microbe (2008)