tbuckley/cabot-search huggingface dataset:
Interleukin-1? repressesMRP2 gene expression through inactivation of interferon regulatory factor 3 in HepG2 cells
Authors: Keiji Hisaeda, Akihiko Inokuchi, Takanori Nakamura, Yukihide Iwamoto, Kimitoshi Kohno, Michihiko Kuwano, Takeshi Uchiumi
Journal: Hepatology (2004)

The human multidrug resistance protein 2 ( MRP 2/ABCC2), expressed on the bile canalicular membrane, mediates the multispecific efflux of several organic anions, including conjugates of glucuronate, sulfate, and glutathione. Expression of MRP2 can be altered in response to environmental stimuli such as cholestasis and jaundice. We previously reported that MRP2 mRNA expression levels are decreased in the nontumorous part of hepatitis C virus-infected human liver tissues, and that inflammatory cytokines inhibit MRP2 expression in human hepatic (HepG2) cells. We investigated the molecular mechanisms by which inflammatory cytokines modulate MRP2 gene expression in hepatic cells. Treatment of human hepatic cells with interleukin-1β (IL-1β) or tumor necrosis factor α resulted in a decrease in the protein and mRNA levels of MRP2 . IL-1β inhibited the transcriptional activity of MRP2 promoter constructs by 40%, and this inhibition of MRP2 promoter activity was mediated through the interferon stimulatory response element (ISRE). Electrophoretic mobility shift assays with IL-1β-treated nuclear extracts showed a decrease in the formation of DNA protein complexes, specifically those including interferon regulatory factor 3 (IRF3). Expression of recombinant human IRF3 increased MRP2 promoter activity. Treatment with a specific extracellular signal-regulated kinase inhibitor relieved IL-1β-induced MRP2 mRNA downregulation and abrogated the binding of IRF3 to the ISRE element. In conclusion , IL-1β induces downregulation of the MRP2 gene by inactivating IRF3 binding to ISRE on the MRP2 promoter in human hepatic cells; this inactivation is accomplished via interference with the extracellular signal-regulated kinase pathway. (Hepatology 2004;39:1574-1582.)
The effect of UV therapy on immune function in patients with psoriasis
Authors: J.W. GILMOUR, J.P. VESTEY, M. NORVAL
Journal: British Journal of Dermatology (1993)

Journal Article The effect of UV therapy on immune function in patients with psoriasis Get access J.W. GILMOUR, J.W. GILMOUR Department of Medical Microbiology, University of Edinburgh Medical School, Edinburgh EH8 9AG, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.P. VESTEY, J.P. VESTEY University Department of Dermatology. Royal Infirmary of Edinburgh, U.K. Search for other works by this author on: Oxford Academic Google Scholar M. NORVAL M. NORVAL Department of Medical Microbiology, University of Edinburgh Medical School, Edinburgh EH8 9AG, U.K. ; Dr M. Norval. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 129, Issue 1, 1 July 1993, Pages 28–38, https://doi.org/10.1111/j.1365-2133.1993.tb03307.x Published: 01 July 1993 Article history Accepted: 04 January 1993 Published: 01 July 1993
Polyamines mediate uncontrolled calcium entry and cell damage in rat heart in the calcium paradox.
Authors: H Koenig, A D Goldstone, J J Trout, C Y Lu
Journal: Journal of Clinical Investigation (1987)

Brief perfusion of heart with calcium-free medium renders myocardial cells calcium-sensitive so that readmission of calcium results in uncontrolled Ca2+ entry and acute massive cell injury (calcium paradox). We investigated the hypothesis that polyamines may be involved in the mediation of abnormal Ca2+ influx and cell damage in the calcium paradox. The isolated perfused rat heart was used for these studies. Calcium-free perfusion promptly (less than 5 min) decreased the levels of polyamines and the activity of their rate-regulating synthetic enzyme, ornithine decarboxylase (ODC), and calcium reperfusion abruptly (less than 15-180 s) increased these components. alpha-Difluoromethylornithine (DFMO), a specific suicide inhibitor of ODC, suppressed the calcium reperfusion-induced increase in polyamines and the concomitant increase in myocardial cellular 45Ca influx, loss of contractility, release of cytosolic enzymes, myoglobin, and protein, and structural lesions. Putrescine, the product of ODC activity, nullified DFMO inhibition and restored the calcium reperfusion-induced increment in polyamines and the full expression of the calcium paradox. Putrescine itself enhanced the reperfusion-evoked release of myoglobin and protein in the absence of DFMO. Hypothermia blocked the changes in heart ODC and polyamines induced by calcium-free perfusion and calcium reperfusion and prevented the calcium paradox. These results indicate that rapid Ca2+-directed changes in ODC activity and polyamine levels are essential for triggering excessive transsarcolemmal transport of Ca2+ and explosive myocardial cell injury in the calcium paradox.
Effects of obesity and weight loss on left ventricular mass and relative wall thickness: survey and intervention study
Authors: K. Karason, I. Wallentin, B. Larsson, L. Sjostrom
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objectives:</b> To investigate the consequences of longstanding obesity on left ventricular mass and structure and to examine the effects of weight loss on these variables. <b>Design:</b> Cross sectional survey and controlled intervention study. <b>Setting:</b> City of Gothenburg and surrounding areas, Sweden. <b>Subjects:</b> 41 obese patients treated with weight reducing gastric surgery, 31 obese patients treated conventionally, and 43 non-obese subjects. <b>Main outcome measures:</b> Changes in left ventricular mass and relative wall thickness. <b>Results:</b> Obese patients had higher blood pressure, greater left ventricular mass, and increased relative wall thickness than did matched non-obese control subjects. Obese subjects treated with gastric surgery had a substantial weight loss and a significant reduction in all variables when compared with conventionally treated obese subjects. Univariate and multivariate analysis of pooled data from the two groups of obese subjects showed that changes in relative wall thickness and left ventricular mass were more closely related to the change in weight than to the concomitant change in blood pressure. <b>Conclusions:</b> Structural heart abnormalities occurring in conjunction with obesity diminish after weight loss. The regression in these structural aberrations is better predicted by the weight loss than by the accompanying reduction in blood pressure. To prevent or improve abnormalities of heart structure in obese people, weight control should be the primary goal; it should be regarded as at least as important as regulating blood pressure. <h3>Key messages</h3> Obesity and hypertension often coexist, leading to various degrees of eccentric and concentric left ventricular hypertrophy These structural heart changes are in turn powerful risk factors for cardiovascular morbidity and mortality Weight loss is followed by a reduction in left ventricular mass and relative wall thickness Changes in left ventricular structure are better predicted by the weight loss than by the accompanying reduction in blood pressure To prevent or improve abnormal heart structure in obese people, weight control should be the primary goal and should be regarded as at least as important as regulating blood pressure
Role of gender and hormone-related events on IgE, atopy, and eosinophils in the Epidemiological Study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy
Authors: Valérie Siroux, Florence Curt, Marie-Pierre Oryszczyn, Jean Maccario, Francine Kauffmann
Journal: Journal of Allergy and Clinical Immunology (2004)
METABOLIC COMORBIDITIES ASSOCIATED WITH ENDOTHELIAL INFLAMMATION AND REDUCED NO-BIOAVALABILITY AS A NOVEL PARADIGM FOR HEART FAILURE WITH PRESERVED EJECTION FRACTION
Authors: Constantijn Franssen, Sophia H. Chen, Andreas Unger, H.I. Korkmaz, J.W. Niessen, Wolfgang Linke, René Musters, Walter Paulus, Nazha Hamdani
Journal: Journal of the American College of Cardiology (2014)
Gene-Environment Interactions and Depression
Authors: Karestan C. Koenen, Sandro Galea
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment
Authors: Liam R Brunham, Janine K Kruit, Terry D Pape, Jenelle M Timmins, Anne Q Reuwer, Zainisha Vasanji, Brad J Marsh, Brian Rodrigues, James D Johnson, John S Parks, C Bruce Verchere, Michael R Hayden
Journal: Nature Medicine (2007)
ENDOSCOPIC RESECTION OF THE PROSTATE: A CRITICAL SURVEY OF 150 CASES
Authors: R. W. Doyle, G. Y. Feggetter
Journal: BMJ (1935)

formed the subject of the investigation, the results of this operation compare very favourably with those obtained under conservative treatment alone.Forty-eight per cent. of the surgical cases were completely cured and 25 per cent.were greatly i.mproved.The figures for the nedical cases are 15 per cent.cured and 43 per cent.greatly improved.'lThe value of these results may be criticized, in that some of the cases are too recent for a complete cure to be claimed.The same doubt exists, however, in regard 'to both the medical and the surgical cases, and does not affect the pertinence of the comparison.Furthermore, while 6ome of the more recent patients who now recard themselves as cured may possibly suffer relapse later, there are doubtless others, now classified as " improved," who will claim a complete cure at a later date.No definite conclusions may be drawn from a com- parison of the number of failures of medical and surgical treatment in this series.The " derelicts" appear to be about equally divided.The clause "unable for work," in Class D, doubless drew to this class several patients wlhose unfitness wvas due to some outside cause.In five cases information to this effect was supplied by the patient.In the small series of cases investigated where gastro- duodenostoiny had leen performed, the results of this operation could not be shown to equal those of gastroenterostomy.In 65 per cent. of the cases investigated post-operative treatment, in the form of restricted diet and alkaline medicatioin, was abandoned within six months of the operation.WVlile very little guidance is available as to what may be regarded as the necessary duration of such treatment, six months cannot be looked upon as an error on the side of safety.It seems reasonable to suggest that, if treatment had been continued over a more prolonged period, the number of unsatisfactory-results recorded would have been considerably less.I am indebted to Dr.
Mechanism by Which Mcl-1 Regulates Cancer-Specific Apoptosis Triggered by mda-7/IL-24, an IL-10–Related Cytokine
Authors: Rupesh Dash, Joanna E. Richards, Zhao-zhong Su, Sujit K. Bhutia, Belal Azab, Mohamed Rahmani, Girija Dasmahapatra, Adly Yacoub, Paul Dent, Igor P. Dmitriev, David T. Curiel, Steven Grant, Maurizio Pellecchia, John C. Reed, Devanand Sarkar, Paul B. Fisher
Journal: Cancer Research (2010)

Abstract Melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24), a cytokine belonging to the IL-10 family, selectively induces apoptosis in cancer cells without harming normal cells by promoting an endoplasmic reticulum (ER) stress response. The precise molecular mechanism by which the ER stress response culminates in cell death requires further clarification. The present study shows that in prostate carcinoma cells, the mda-7/IL-24–induced ER stress response causes apoptosis by translational inhibition of the antiapoptotic protein myeloid cell leukemia-1 (Mcl-1). Forced expression of Mcl-1 blocked mda-7/IL-24 lethality, whereas RNA interference or gene knockout of Mcl-1 markedly sensitized transformed cells to mda-7/IL-24. Mcl-1 downregulation by mda-7/IL-24 relieved its association with the proapoptotic protein Bak, causing oligomerization of Bak and leading to cell death. These observations show the profound role of the Bcl-2 protein family member Mcl-1 in regulating cancer-specific apoptosis induced by this cytokine. Thus, our studies provide further insights into the molecular mechanism of ER stress–induced cancer-selective apoptosis by mda-7/IL-24. As Mcl-1 is overexpressed in the majority of prostate cancers, mda-7/IL-24 might provide an effective therapeutic for this disease. Cancer Res; 70(12); 5034–45. ©2010 AACR.
Impact of highly conserved HLA haplotype on acute graft-versus-host disease
Authors: Satoko Morishima, Seishi Ogawa, Aiko Matsubara, Takakazu Kawase, Yasuhito Nannya, Koichi Kashiwase, Masahiro Satake, Hiroo Saji, Hidetoshi Inoko, Shunichi Kato, Yoshihisa Kodera, Takehiko Sasazuki, Yasuo Morishima
Journal: Blood (2010)
CERVICAL RIBS IN CHILDREN
Authors: A. H. Southam, W. J. S. Bythell
Journal: BMJ (1924)

ETE BenS844 NOV-8, 411 Ib~~~~~~~~~~~~~~~~~~~~~~~~~~~ ifmore cases of pulmonary tuberculosis were diagnosed while theyare still Group I patients (that is, with only 4.8 per cent.showing laryngeal lesions) instead of Group lII '(that is, with 31.5 per cenit.with the larynx involved).More cures could be effected if eveiry case of persistent huskiness or throat discomfort were earlier submitted to a skilled examination.
TCT-739 Improved One Year All Cause Mortality following Transcatheter Aortic Valve Implantation (TAVI) Beyond The Learning Curve Experience: Insights From Glenfield-Leicester UK TAVI Registry
Authors: Herath Ashan GUNARATHNE, Elved Roberts, Derek Chin, Amerjeet S. Banning, Alison Beech, Mariuca Vasa-Nicotera, Hasan Jilaihawi
Journal: Journal of the American College of Cardiology (2014)
Epidemiology of Silicone Breast Implants
Authors: John Whysner
Journal: Annals of Internal Medicine (1997)

Letters15 April 1997Epidemiology of Silicone Breast ImplantsJohn Whysner, MD, PhDJohn Whysner, MD, PhDWashington Occupational Health Associates, Inc., Washington, DC 20036Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-8-199704150-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The recent review [1] by Silverman and colleagues (employees of the Food and Drug Administration [FDA]) concluded, as has every review and epidemiologic study published in authoritative peer-reviewed journals, that silicone breast implants do not lead to any marked increases in well-defined connective tissue diseases. These epidemiologic studies have properly addressed the individual case reports and clinical series that initially raised some alarm about the safety of breast augmentation and reconstruction with silicone implants. The case reports drew attention to a possible problem that was not confirmed when submitted to more rigorous scrutiny [2-4].Why, then, did ...References1. Silverman BG, Brown SL, Bright RA, Kaczmarek RG, Arowsmith-Lowe JB, Kessler DA. Reported complications of silicone gel breast implants: an epidemiologic review. Ann Intern Med. 1996; 124:744-56. Google Scholar2. American College of Rheumatology. Statement on silicone breast implants. Atlanta: American College of Rheumatology; 1995. Google Scholar3. Council on Scientific Affairs, American Medical Association. Silicone gel breast implants. JAMA. 1993; 70:2602-6. Google Scholar4. Gott DM, Tinkler JJ. Silicone Implants and Connective Tissue Disease. Evaluation of Evidence for an Association between the Implantation of Silicones and Connective Tissue Disease. United Kingdom: Medical Devices Agency; 1994. Google Scholar Author, Article, and Disclosure InformationAffiliations: Washington Occupational Health Associates, Inc., Washington, DC 20036 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1997Volume 126, Issue 8Page: 667KeywordsClinical epidemiologyConnective tissue diseasesEpidemiological methods and statisticsEpidemiologyFood and Drug AdministrationSafetySafety studiesSigns and symptoms Issue Published: 15 April 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Correlation of serum follicular stimulating hormone (FSH) and luteinizing hormone (LH) as measured by radioimmunoassay in disorders of sexual development
Authors: Robert Penny, Harvey J. Guyda, Alice Baghdassarian, Ann J. Johanson, Robert M. Blizzard
Journal: Journal of Clinical Investigation (1970)

Serum FSH and LH levels in 104 patients with disorders of sexual development were determined by radioimmunoassay and compared with serum FSH and LH levels in 164 normal individuals.32 of 35 gonadal dysgenesis patients (ages 4.8-18.9 yr) had serum FSH levels which were elevated above the range of normal for chronological age, and 19 had serum LH levels similarly elevated. All patients with elevated serum LH levels were 11 yr of age or older. However, 8 of 10 gonadal dysgenesis patients, ages 4.8-10.9 yr, had serum FSH levels elevated above the normal range. In accord with these observations was the finding that in normal girls, serum FSH levels may increase at an earlier age than do serum LH levels (FSH, 5-8 yr of age; LH, 9-10 yr of age). These data indicate that serum FSH determinations may be helpful in diagnosing gonadal dysgenesis during childhood. Serum gonadotropin levels within the range of normal for chronological age were found in 2 of 18 girls with idiopathic isosexual precocity. The other 16 had serum FSH levels elevated above the range of normal for chronological age, and 8 also had serum LH levels similarly elevated. In all instances serum FSH and LH levels were in the range expected for the stage of sexual development. In 35 boys, ages 13.1-17.8 yr, with delayed adolescence, serum gonadotropin levels correlated with stage of sexual development and, therefore, were often less than those expected for age.8 patients with premature pubarche, 5 patients with premature thelarche, and 3 patients with adolescent gynecomastia had serum gonadotropin levels within the range of normal for chronological age.
Orthopedic Surgery of the Dog and Cat
Authors: Peter A. Casagrande
Journal: JAMA (1961)

Review of this book was a refreshing experience for an orthopedist. Sound orthopedic principles established for the care of human beings are used in the treatment of trauma and musculoskeletal diseases of our beloved household pets. A complete review of musculoskeletal trauma and its treatment is vividly portrayed by means of reproductions of roentgenograms and photographs of preoperative, operative, and postoperative conditions. This is an excellent book for veterinarians and those embryonic orthopedic surgeons assigned to the animal laboratory.
Brain Surgery: Complication Avoidance and Management
Authors: John E. Adams
Journal: JAMA (1993)

In 1946, a new text of neurosurgery by Bancroft and Pilcher appeared (<i>Surgical Treatment of the Nervous System</i>, Philadelphia, Pa, JB Lippincott), a single volume that encompassed the complete field of neurosurgery. Now,<i>Brain Surgery: Complication Avoidance and Management</i>, edited by Apuzzo, is the third multiauthored neurosurgical text to be published in the past 10 years. It is therefore an obvious inference that neurosurgery has expanded remarkably as a specialty and that, of necessity, subspecialties have developed within it. These three texts share many authors in common, each an authority in a special area. One might question the need for a third such text. However, the rapid growth of new technologies applicable to the surgical treatment of more and more pathological entities involving the cranium and its contents, and the increasing numbers of neurosurgeons, provide ample justification for the publication of this new text in the "Decade of the Brain."
Aptamer-conjugated and doxorubicin-loaded unimolecular micelles for targeted therapy of prostate cancer
Authors: Wenjin Xu, Imtiaz A. Siddiqui, Minakshi Nihal, Srikanth Pilla, Kimberly Rosenthal, Hasan Mukhtar, Shaoqin Gong
Journal: Biomaterials (2013)
A Definition for Zero Potential
Authors: C. V. NELSON, P. GASTONGUAY
Journal: Circulation Research (1959)

Equations are developed for the potential due to a source and sink, or dipole, inside a circle of finite resistivity surrounded by a two-dimensional infinite medium of different resistivity. When the resistivity of the external medium is allowed to increase to infinity, the resulting equations give identical results to those presented by Bayley for the dipole potential in an insulating circle. A method of defining the zero of potential for a bounded medium is proposed.
"Low-Probability" Ventilation-Perfusion Scans
Authors: Martin P. Jacobs
Journal: Annals of Internal Medicine (1991)

Letters1 April 1991"Low-Probability" Ventilation-Perfusion ScansMartin P. Jacobs, MDMartin P. Jacobs, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-7-604 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Hull and Raskob (1) state that interpreting a ventilation-perfusion scan pattern as low probability ". . . is no longer clinically correct. . . ." They agree with Moser (2) that such scans should be interpreted as nondiagnostic (with normal or high probability being the only other interpretive options). Rather than improve patient care, this approach would markedly diminish the usefulness of ventilation-perfusion scans and would subject an unnecessarily high proportion of patients to pulmonary angiography.Other investigators have shown that death or morbidity from pulmonary emboli is very infrequent in patients with low-probability ventilation-perfusion scan patterns...References1. HullRaskob RG. Low-probability lung scan findings: a need for change. Ann Intern Med. 1991;114:142-3. LinkGoogle Scholar2. Moser K. Venous thromboembolism. Am Rev Respir Dis. 1990;141:235-49. CrossrefMedlineGoogle Scholar3. LeeBielloKumarSiegel MDBB. "Low probability" ventilation-perfusion scintigrams: clinical outcomes in 99 patients. Radiology. 1985;156:497-500. CrossrefMedlineGoogle Scholar4. SmithMaherMillerAlderson RJRP. Clinical outcomes of patients with suspected pulmonary embolism and low-probability aerosol-perfusion scintigrams. Radiology. 1987;164:731-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByReplyLung scanning in the diagnosis of pulmonary embolism: The emperor redressed 1 April 1991Volume 114, Issue 7Page: 604-605KeywordsAngiographyMorbidityPatientsVentilation perfusion Issue Published: 1 April 1991 PDF DownloadLoading ...