tbuckley/cabot-search huggingface dataset:
Ejection fraction and outcomes in patients with atrial fibrillation and heart failure: the Loire Valley Atrial Fibrillation Project
Authors: Amitava Banerjee, Sophie Taillandier, Jonas Bjerring Olesen, Deirdre A. Lane, Benedicte Lallemand, Gregory Y.H. Lip, Laurent Fauchier
Journal: European Journal of Heart Failure (2012)
Cell renewal, cell differentiation and programmed cell death (apoptosis) in pilomatrixoma
Authors: A. FAYYAZI, A. SORURI, H.J. RADZUN, J.H. PETERS, H. BERGER
Journal: British Journal of Dermatology (1997)

Pilomatrixoma is a benign tumour of the cutaneous adnexa. Histologically, pilomatrixoma comprises masses of immature basophilic cells, small numbers of polygonal squamoid cells, few transitional cells, and clusters of 'shadow cells'. The mechanism leading to the formation of shadow cells is still unknown. Skin biopsy specimens of pilomatrixoma (n = 15) were studied histologically, immunohistologically, and by applying the in situ end-labelling technique. The basal layer of the basophilic cells induced most of the proliferating cells with high expression of bcl-2 and cytokeratin 19. The overlying basophilic cells showed a negligible mitotic activity, a high significant accumulation of p53 protein, and a heterogeneous, but progressive loss of bcl-2 and cytokeratin 19. They developed either into squamoid cells or into transitional cells. The squamoid cells were characterized as differentiated cells resembling mature keratinocytes of stratified mucosa. The transitional cells could be shown to represent apoptotic cells proceeding to shadow cells. The data suggest that apoptosis is the main mechanism leading to the development of the dead shadow cells and is most probably responsible for the banal biological behaviour of pilomatrixoma. Apart from that, pilomatrixoma represents a suitable biological model to study apoptosis in humans.
Response: Re: Novel Therapies for Metastatic Castrate-Resistant Prostate Cancer
Authors: F. Dayyani, G. E. Gallick, C. J. Logothetis, P. G. Corn
Journal: JNCI Journal of the National Cancer Institute (2012)

We would like to thank Dr Sartor and Dr Parker for their interest in our review article.We fully agree on the potential importance of targeting the osteoblastic niche with radioactive agents in prostate cancer, a strategy our group devised and published previously with strontium-89 (1).Although the recently reported results with radium-223 are promising, they were not available at the time of submission of our review.Our review focused only on already published phase II and III clinical trials with novel agents, and at the time of publication of the review, the findings from the phase III radium-223 trial (ClinicalTrials.govidentifier NCT00699751) were only available as a meeting abstract.We look forward to learning more about the details of this trial once it is published in a peer-reviewed journal.
Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium.
Authors: H Hauner, G Entenmann, M Wabitsch, D Gaillard, G Ailhaud, R Negrel, E F Pfeiffer
Journal: Journal of Clinical Investigation (1989)

Stromal-vascular cells obtained from adult human subcutaneous adipose tissue were cultured in a chemically defined serum-free medium. In the presence of 0.2 nM triiodothyronine and 0.5 microM insulin, up to 25% of the cells were able to undergo terminal adipose differentiation within 18 d, as assessed by lipid accumulation and the expression of lipoprotein lipase (LPL) and glycerol-3-phosphate dehydrogenase (GPDH) activities. Addition of cortisol resulted in a potent dose-dependent stimulation of the adipose differentiation process. Cortisol could be replaced by dexamethasone and partly by aldosterone, but not by sex steroids. The proportion of differentiated cells was dependent upon the age of the donor; when isolated from young adults, up to 70% of the stromal-vascular cells expressed the adipocyte phenotype as compared with 5-10% when the cells were isolated from the oldest subjects. An inverse relationship was observed between the age of the 27 normal-weight donors and the extent of GPDH expression after maintenance of the cells for 18 d in chemically defined medium supplemented with insulin, triiodothyronine, and cortisol (r = -0.787, P less than 0.001). It is concluded that adult human adipose tissue still contains precursor cells that are able to undergo adipose differentiation in vitro. This improved culture system may offer the opportunity to characterize other adipogenic factors as well as antiadipogenic factors involved in the control of adipose tissue growth.
Immunosuppression in Sepsis
Authors: Peter A. Ward
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dactylitis also involving the synovial sheaths in the palm of the hand: two more cases studied by magnetic resonance imaging
Authors: A. PADULA, C. SALVARANI, L. BAROZZI, M. DE MATTEIS, P. PAVLICA, F. CANTINI, I. OLIVIERI
Journal: Annals of the Rheumatic Diseases (1998)

We previously reported on the case of a 37 year old woman suffering from B27 positive psoriatic arthritis and showing dactylitis of the middle finger also involving the uncommon synovial sheaths communicating with the ulnar bursa.1 The continuity of flexor synovial sheath involvement was shown by ultrasonography. We have recently seen two similar cases, which we studied by magnetic resonance imaging (MRI). One patient also had synovitis together with pitting oedema of the dorsum of the hand, which has been described in elderly patients with spondyloarthritis (SpA).2-5 

We previously reported on the case of a 37 year old woman suffering from B27 positive psoriatic arthritis and showing dactylitis of the middle finger also involving the uncommon synovial sheaths communicating with the ulnar bursa.1 The continuity of flexor synovial sheath involvement was shown by ultrasonography. We have recently seen two similar cases, which we studied by magnetic resonance imaging (MRI). One patient also had synovitis together with pitting oedema of the dorsum of the hand, which has been described in …
The Anesthesiologist in Patient Care
Authors: Ernest A. Bragg
Journal: JAMA (1970)

To the Editor.—  They erred badly on one point in their assumption about those least responsible. Radiologists, doing therapy, spend a major po-tion of their careers giving palliative x-ray therapy for relief of pain to patients dying of metastatic cancer.  Requests for negative euthanasia by patients sent for diagnostic x-ray work are commonplace, and request for positive euthanasia are not rare. On some occasions, a preliminary conversation with a moribund patient leads me to cancel a barium enema or other examination which will be nothing but useless torture to a dying patient who asks only to be left alone to die in peace.
Superior vena caval obstruction complicating fibreoptic gastroscopy.
Authors: J Dawson
Journal: BMJ (1977)

of these hair dyes it will be important to take account of smoking habits in any such studies of smoking-related cancers, particularly in view of a recent report suggesting that beauticians have an increased risk of lung cancer.9We thank the consultants who allowed us to interview patients under their care, and the Toilet Preparations Federation and the manufacturers of hair dyes, who helped us by providing information about hair care preparations.We also thank Mr Paul Humphreys, who helped in the analysis of this study, and Mr Peter Smith, Mr Julian Peto, and Sir Richard Doll for their helpful comments.
Visualization of Jugular Vein on a Thallium-201 Scan for Thyroid Cancer
Authors: SHUNICHI NAKANO, YOSHIHISA HASEGAWA, KEIKO KURIYAMA, AKIYOSHI KAJITA, SHIGEYUKI ISHIGAMI
Journal: Clinical Nuclear Medicine (1989)

A 52 year-old woman with recurrent thyroid cancer showed an accumulation of TI-201 chloride in the left side of the neck. This proved to be reflux and retention of TI-201 chloride in the left internal jugular vein and was verified with a Tc-99m HSA flow study. This phenomenon could be mistaken for metastases of thyroid cancer.
Maternal HIV-1 viral load and vertical transmission of infection: The Ariel Project for the prevention of HIV transmission from mother to infant
Authors: Yunzhen Cao, Paul Krogstad, Bette T. Korber, Richard A. Koup, Mark Muldoon, Catherine Macken, Jia-Li Song, Zhanqun Jin, Jla-Qi Zhao, Sheila Clapp, Irvin S.Y. Chen, David D. Ho, Arthur J. Ammann
Journal: Nature Medicine (1997)
Withdrawal of Nonfutile Life Support After Attempted Suicide
Authors: Samuel M. Brown, C. Gregory Elliott, Robert Paine
Journal: The American Journal of Bioethics (2013)

End-of-life decision making is fraught with ethical challenges. Withholding or withdrawing life support therapy is widely considered ethical in patients with high treatment burden, poor premorbid status, or significant projected disability even when such treatment is not "futile." Whether such withdrawal of therapy in the aftermath of attempted suicide is ethical is not well established in the literature. We provide a clinical vignette and propose criteria under which such withdrawal would be ethical. We suggest that it is appropriate to withdraw life support, regardless of the cause of the critical illness or disability, when the following criteria are met: (1) Surrogates request withdrawal of care and the adequacy of surrogates is confirmed, (2) an external reasonability standard is met, (3) passage of time, perhaps 72 hours, to allow certainty regarding the patient's wishes, and (4) psychiatric morbidity should be considered as grounds for withdrawal only in truly treatment-refractory cases. Fundamentally, we believe the question to ask is, "If this were not an attempted suicide, would a request to withdraw care be reasonable?" We believe that under these circumstances, such withdrawal of life support, even in an individual who has attempted suicide, does not constitute physician assistance with suicide and is distinct from physician aid-in-dying in several important respects.
THE EFFECTS OF CO-ADMINISTERING A MONOCLONAL ANTIBODY TO PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 SERINE PROTEASE, REGN727/SAR236553, WITH 10 AND 80 MG ATORVASTATIN COMPARED TO 80 MG ATORVASTATIN ALONE IN PATIENTS WITH PRIMARY HYPERCHOLESTEROLEMIA (NCT: 01288469)
Authors: Eli M. Roth, James McKenney, Corinne Hanotin, Gaelle Asset, Evan Stein
Journal: Journal of the American College of Cardiology (2012)
JUVENILE DERMATITIS HERPETIFORMIS IN JAMAICA: CLINICAL AMD GASTROINTESTINAL FEATURES
Authors: JOYCE WARNER, S. E. H. BROOKS, W. P. T. JAMES, SHEILAH LOUISY
Journal: British Journal of Dermatology (1972)

Summary.— The clinical features and investigations relating to gastrointestinal function are presented in 12 cases of juvenile dermatitis herpetiformis seen over a period of 2 years in Jamaica. None of the children had evidence of steatorrhoea. Jejunal biopsy in 10 cases showed normal mucosa in l, ridging and convolutions in 8 and a flat mucosa in 1. Electronmieroscopical changes are also described. Lactase deficiency and lactose intolerance were common. These findings may be related to malnutrition in infancy or at the time of biopsy. An interesting feature was relapse following iodine contrast media used during jejunal biopsy and a high incidence of iodine in drinking water in some narts of Jamaica.
Liver disease in pregnancy
Authors: Eileen J. Hay
Journal: Hepatology (2008)

Abnormal liver tests occur in 3%–5% of pregnancies, with many potential causes, including coincidental liver disease (most commonly viral hepatitis or gallstones) and underlying chronic liver disease. However, most liver dysfunction in pregnancy is pregnancy-related and caused by 1 of the 5 liver diseases unique to the pregnant state: these fall into 2 main categories depending on their association with or without preeclampsia. The preeclampsia-associated liver diseases are preeclampsia itself, the hemolysis (H), elevated liver tests (EL), and low platelet count (LP) (HELLP) syndrome, and acute fatty liver of pregnancy. Hyperemesis gravidarum and intrahepatic cholestasis of pregnancy have no relationship to preeclampsia. Although still enigmatic, there have been recent interesting advances in understanding of these unique pregnancy-related liver diseases. Hyperemesis gravidarum is intractable, dehydrating vomiting in the first trimester of pregnancy; 50% of patients with this condition have liver dysfunction. Intrahepatic cholestasis of pregnancy is pruritus and elevated bile acids in the second half of pregnancy, accompanied by high levels of aminotransferases and mild jaundice. Maternal management is symptomatic with ursodeoxycholic acid; for the fetus, however, this is a high-risk pregnancy requiring close fetal monitoring and early delivery. Severe preeclampsia itself is the commonest cause of hepatic tenderness and liver dysfunction in pregnancy, and 2%–12% of cases are further complicated by hemolysis (H), elevated liver tests (EL), and low platelet count (LP)—the HELLP syndrome. Immediate delivery is the only definitive therapy, but many maternal complications can occur, including abruptio placentae, renal failure, subcapsular hematomas, and hepatic rupture. Acute fatty liver of pregnancy is a sudden catastrophic illness occurring almost exclusively in the third trimester; microvesicular fatty infiltration of hepatocytes causes acute liver failure with coagulopathy and encephalopathy. Early diagnosis and immediate delivery are essential for maternal and fetal survival.
Are Fatty Acids a Link Between Diabetes and Lowered Cognitive Performance?
Authors: Celia M. Ross
Journal: Diabetes Care (2005)

Burden of Type 2Diabetes in Young Korean Adults Owing to Obesity P revious large-scale surveys reported that magnitudes of increase in type 2 diabetes and obesity are more remarkable among young adults than older ones, whereas prevalences of these are lower in young adults (1,2).These epidemiological findings have very important implications in clinical practice and public health policies.Despite its significance, however, there are few reports on the effects of obesity on the risk of disease in younger generations compared with older people.We investigated the effects of BMI on the development of type 2 diabetes according to age-group in a large-scale, 10year follow-up cohort, the Korea National Health Insurance Corporation (KNHIC) study.The KNHIC provides medical insurance to public servants, teachers, and their dependents.Of KNHIC members, 883,697 men and women aged 25-64 years in 1992 were selected as study subjects.All of the subjects were required to complete a medical questionnaire and have their general health status assessed every 2 years by the KNHIC.A more detailed description of the subjects has been published (3).Type 2 diabetes was diagnosed when the fasting plasma glucose level is Ն126 mg/dl or subjects were treated for type 2 diabetes.BMI was categorized by 1-unit increments to examine the overall disease risks in detail with regard to the degree of obesity.In the analyses, the reference point was set as a BMI of 21 kg/m 2 .We found a significant linear dosedependent relationship between BMI and type 2 diabetes in all age-groups (all P Ͻ 0.05 for the linear trend), and these trends were more pronounced in the younger groups.The interaction between BMI and age-group was statistically significant (P ϭ 0.003).With the reference BMI level of 21 kg/m 2 , subjects with a BMI of 25 kg/m 2 who were between 20 and 29 years old had a relative risk of 2.24 (95% CI 1.95-2.49),while subjects aged 30 -39, 40 -49, and Ն50 years with this BMI had relative risks of 2.28 (2.13-2.43),1.90 (1.78 -2.02), and 1.80 (1.65-1.95),respectively.Subjects with a BMI of 30 kg/m 2 who were between 20 and 29 years old had a relative risk of 6.69 (4.52-8.33),while subjects aged 30 -39, 40 -49, and Ն50 years with this BMI had relative risks of 4. 90 (4.11-5.58),4.09 (3.47-4.62),and 2.67 (2.05-3.17),respectively.The discrepancy between these risks increased with BMI.We found steeper dosedependent relationships between BMI and type 2 diabetes in the younger age-groups than in the older groups.Because type 2 diabetes leads to longterm morbidity, the prevention of obesity in younger generations and the early identification of overt disease need to be considered as critical public health issues.Therefore, public effort is needed to control weight problems and obesity in young people to prevent future health problems before it is too late.
Dutch politicians are under pressure to hold "time to die" debate
Authors: T. Sheldon
Journal: BMJ (2010)

The Dutch parliament is under mounting pressure to debate legalising assisted suicide for older people who are not dying but feel their life is over. A campaign by a group of prominent senior figures in Dutch society has raised 85 000 signatures in ten days—exceeding the 40 000 needed to trigger a parliamentary debate under a “citizens’ initiative” law.

The group, called Of One’s Own Free Will (Uit Vrije Wil), seeks to “legalise help with dying for older people who regard their life as complete, at their explicit request and under conditions of carefulness and verifiability.” The group includes former health minister Hedy d’Ancona, …
Efficacy of recombinant birch pollen vaccine for the treatment of birch-allergic rhinoconjunctivitis
Authors: Gabrielle Pauli, Tina H. Larsen, Sabina Rak, Friedrich Horak, Elide Pastorello, Rudolph Valenta, Ashok Purohit, Monica Arvidsson, Alexander Kavina, Jan W. Schroeder, Nadine Mothes, Susanne Spitzauer, Armelle Montagut, Sylvie Galvain, Michel Melac, Claude André, Lars K. Poulsen, Hans-Jorgen Malling
Journal: Journal of Allergy and Clinical Immunology (2008)
Diesel-exhaust particulates inoculated by the intranasal route have an adjuvant activity for IgE production in mice
Authors: Shigeru Takafuji, Shuji Suzuki, Kazuhiro Koizumi, Kenji Tadokoro, Terumasa Miyamoto, Ryosuke Ikemori, Masaharu Muranaka
Journal: Journal of Allergy and Clinical Immunology (1987)
Comparison of injury in Iran national junior and youth football players
Authors: Mostafa Zarei, Nader Rahnama, A Rezaei, Jalil Reisi
Journal: British Journal of Sports Medicine (2010)

Football is one of the most popular sports in the world, but the rate of injury in this sport is high. A limited number of studies on the incidence of injuries in football players of differing ages have been published. The aim of this study was to establish a profile of injury in Iran national junior and youth football players. The team physician recorded details of all injuries that occurred during both training and matches. A total of 29 injuries were documented across both age groups, which is equivalent to an incidence of 36.51 injuries per 1000 play hours, the injury frequency rate during competition (64.15) being significantly (Z=2.51, p&lt;0.05) higher than training (29.75). There was no significant difference in injury frequency between two age groups (36.1 injuries (U15) vs 37.9 injuries (U19) per 1000 h) (Z=0.05, p &gt; 0.05) but junior players (U15) received more injuries during competition than youth players (U19) (86.08 injuries vs 46.41 injuries per 1000 h matches) (Z=2.43, p &lt; 0.05). Also there was no significant difference in injury frequency during training (29.6 injuries vs 30.45 injuries per 1000 h training) (p &gt; 0.05). Midfielders sustained greater percentage of injuries (55.2%). Most injuries were located in the lower extremities (n = 23, 79.3%), with the majority affecting the groin(31%) and ankle (17.2%) followed by thigh (13.8%) and knee (10.3%). Strains (34.5%) were the most common type of injury sustained in all players followed by sprains (17.2%) and contusions (17.2%).The overall rate of injury acquisition in the present investigation was 36.51 per 1000 h of exposure, this result was higher than recently observed for elite French youth football players (4.8). Junior players (U15) had twice as many injuries per 1000 h of exposure than youth players (U19). It seems that youth players (U19) are better trained to meet the demands of playing games than are junior players (U15).
Skin exudate levels of interleukin 6, interleukin i and other cytokines in mycosis fungoides
Authors: FRANCES LAWLOR, N.P. SMITH, R.D.R. CAMP, K.B. BACON, ANNE KOBZA BLACK, M.W. GREAVES, A.J.H. GEARING
Journal: British Journal of Dermatology (1990)

Journal Article Skin exudate levels of interleukin 6, interleukin i and other cytokines in mycosis fungoides Get access FRANCES LAWLOR, FRANCES LAWLOR Institute of Dermatology, St Thomas's Hospital, London Dr Frances Lawlor, Institute of Dermatology, St Thomas's Hospital, Lambeth Palace Road, London SE17EH, U.K. Search for other works by this author on: Oxford Academic Google Scholar N.P. SMITH, N.P. SMITH Skin Tumour Unit, St John's Hospital for Diseases of the Skin, London Search for other works by this author on: Oxford Academic Google Scholar R.D.R. CAMP, R.D.R. CAMP Institute of Dermatology, St Thomas's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar K.B. BACON, K.B. BACON Institute of Dermatology, St Thomas's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar ANNE KOBZA BLACK, ANNE KOBZA BLACK Institute of Dermatology, St Thomas's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar M.W. GREAVES, M.W. GREAVES Institute of Dermatology, St Thomas's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar A.J.H. GEARING A.J.H. GEARING National Institute for Biological Standards and Control, South Mimms, Hertfordshire, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 123, Issue 3, 1 September 1990, Pages 297–304, https://doi.org/10.1111/j.1365-2133.1990.tb06288.x Published: 01 September 1990