Sclerosing Hyaline Necrosis of the Liver in the Chronic Alcoholic
Authors: HUGH A. EDMONDSON
Journal: Annals of Internal Medicine (1963)

Article1 November 1963Sclerosing Hyaline Necrosis of the Liver in the Chronic AlcoholicA Recognizable Clinical SyndromeHUGH A. EDMONDSON, M.D., F.A.C.P., ROBERT L. PETERS, M.D., TELFER B. REYNOLDS, M.D., F.A.C.P., OLIVER T. KUZMA, M.D.HUGH A. EDMONDSON, M.D., F.A.C.P.Search for more papers by this author, ROBERT L. PETERS, M.D.Search for more papers by this author, TELFER B. REYNOLDS, M.D., F.A.C.P.Search for more papers by this author, OLIVER T. KUZMA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-5-646 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years we have observed a group of alcoholic patients who present a symptom complex accompanied by a distinctive morphologic lesion in the hepatic cells that has been known as alcoholic hyalin or "Mallory bodies." This morphologic change was first described by Mallory in 1911 (1) and further elucidated by numerous pathologists (2-7). However, the recognition of a clinical syndrome associated with it came much later, Phillips and Davidson (8) first calling attention to "acute hepatic insufficiency of the chronic alcoholic" in 1954. A few publications pertaining to the disorder have appeared since 1954. Such terms as florid cirrhosis...References1. MALLORY FB: Cirrhosis of the liver: five different lesions from which it may arise. Bull. Hopkins Hosp. 22: 1, 1911. Google Scholar2. POPPERFRANKLIN HM: Viral versus toxic hepatic necrosis. Arch. Path. 46: 338, 1948. MedlineGoogle Scholar3. HALLOPHULS EMW: Progressive alcoholic cirrhosis: report of 4 cases. Amer. J. Path. 1: 477, 1925. MedlineGoogle Scholar4. HALLMORGAN EMWA: Progressive alcoholic cirrhosis: a clinical and pathologic study of 68 cases. Arch. Path. 27: 672, 1939. Google Scholar5. DAVISCULPEPPER WDWS: Cirrhosis of the liver associated with alcoholism: report of acute exacerbation with serial liver biopsies. Ann. Intern. Med. 29: 942, 1948. LinkGoogle Scholar6. MOON VH: Histogenesis of atrophic cirrhosis. Arch. Path. 13: 691, 1932. Google Scholar7. HALLOLSONDAVIS FMAYFE: Portal cirrhosis: clinical and pathologic review of 782 cases from 16, 600 necropsies. Amer. J. Path. 29: 993, 1953. MedlineGoogle Scholar8. PHILLIPSDAVIDSON GBCS: Acute hepatic insufficiency of the chronic alcoholic. Arch. Intern. Med. (Chicago) 94: 585, 1954. CrossrefGoogle Scholar9. POPPERSZANTOPARTHASARATHY HPBM: Florid cirrhosis, a review of 35 cases. Amer. J. Clin. Path. 25: 889, 1955. CrossrefMedlineGoogle Scholar10. GALL EA: The diagnosis of hepatitis by needle biopsy, in Hepatitis Frontiers, edited by HARTMAN, F. W., Little Brown & Co. Boston 1957. Google Scholar11. TISDALEKLATSKIN WAG: The fever of Laennec's cirrhosis. Yale J. Biol. and Med. 33: 94, 1960. MedlineGoogle Scholar12. PÉREZ-TAMAYO R: Diffuse interstitial cirrhosis. Amer. J. Clin. Path. 29: 226, 1958. CrossrefMedlineGoogle Scholar13. BECKETTLIVINGSTONEHILL AGABKR: Acute alcoholic hepatitis with jaundice. Brit. Med. J. 5260: 1113, 1961. CrossrefGoogle Scholar14. BECKETTLIVINGSTONEHILL AGABKR: Acute alcoholic hepatitis with jaundice. Brit. Med. J. 5304: 580, 1962. CrossrefGoogle Scholar15. RICEYESNER JDR: The prognostic significance of so-called Mallory Bodies in portal cirrhosis. Arch. Intern. Med. (Chicago) 105: 99, 1960. CrossrefGoogle Scholar16. COLMANSHEIN RWHM: Leukemoid reaction, hyperuricemia, and severe hyperexia complicating a fatal case of acute fatty liver of the alcoholic. Ann. Intern. Med. 57: 110, 1962. LinkGoogle Scholar17. SUMMERSKILLDAVIDSONDIBLEMALLORYSHERLOCKTURNERWOLFE WHCSJHGKSMDSJ: Cirrhosis of the liver: a study of alcoholic and nonalcoholic patients in Boston and London. New Eng. J. Med. 262: 1, 1960. CrossrefMedlineGoogle Scholar18. MALLORY FB: Cirrhosis of the liver (Shattuck Lecture). New Eng. J. Med. 206: 1231, 1932. CrossrefGoogle Scholar19. HALESALLANHALL MRJSEM: Injection corrosion studies of normal and cirrhotic livers. Amer. J. Path. 35: 909, 1959. MedlineGoogle Scholar20. REYNOLDSGELLERREDEKER TBHMAG: Wedged hepatic venous pressure: a clinical evaluation. Amer. J. Med. 22: 341, 1957. CrossrefMedlineGoogle Scholar21. DAVIDSONPOPPER CSH: Cirrhosis in alcoholism, an editorial. Amer. J. Med. 27: 193, 1959. CrossrefMedlineGoogle Scholar22. NORKINWEITZELCAMPAGNA-PINTOMACDONALDMALLORY SARDRAGK: "Alcoholic" hyalin in human cirrhosis: histochemical studies. Amer. J. Path. 37: 49, 1960. MedlineGoogle Scholar23. BECKER JP: The nature of alcoholic hyaline, a histochemical study. Lab. Invest. 10: 527, 1961. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, CaliforniaFrom the Departments of Pathology and Medicine of the University of Southern California; and the Los Angeles and the John Wesley County Hospitals, Los Angeles, California.This work was supported in part by grant A-5801 from the National Institutes of Health, United States Public Health Service, Bethesda, Maryland.Requests for reprints should be addressed to Hugh A. Edmondson, M.D., Department of Pathology, University of Southern California, School of Medicine, 2025 Zonal Avenue, Los Angeles 33, California. 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