tbuckley/cabot-search huggingface dataset:
Formation, occurrence and analysis of polychlorinated dibenzofurans, dioxins and related compounds.
Authors: H R Buser
Journal: Environmental Health Perspectives (1985)

In several accidents (fires, explosions) involving electrical systems containing polychlorinated biphenyls (PCBs) or benzenes (PCBZs), the formation of polychlorinated tricyclic aromatic compounds such as polychlorinated dibenzofurans (PCDFs), dibenzo-p-dioxins (PCDDs) and biphenylenes (PCBPs) was observed. These findings were not surprising in light of our previous studies on the formation of PCDFs and PCDDs from the thermolysis (500-750 degrees C in presence of air) of PCBs or PCBZs. In these experiments we identified three main and a fourth minor reaction pathway leading to PCDFs from PCBs. The three main reactions involved the loss of ortho-Cl2, and the losses of ortho-HCl with and without a 2,3-chlorine shift. The fourth, minor reaction route found with some PCBs, involved the loss of ortho-H2. These reaction pathways were intramolecular cyclizations via oxidation to phenolic compounds. Thermolysis of commercial PCBs (Aroclor 1254 and 1260) yielded the same PCDF isomers as expected from the main PCB components via these four reaction pathways; the isomers formed included the toxic 2,3,7,8-substituted tetra-, penta- and hexa-CDFs. Thermolysis of PCBZs involved complex condensation reactions with multiple rearrangements leading to PCDFs as well as PCDDs. Again oxidation to phenolic products was involved but the reaction routes are not yet fully elucidated. The results of samples from transformer and capacitor accident sites showed very complex PCDF mixtures with 2,3,7,8-substituted isomers as main components and originating from the PCBs in the transformer liquid. The unusual presence of PCDDs in samples from the Binghamton accident originates from PCBZs present in transformer fluid of that specific installation, thus confirming our previous thermolysis findings.(ABSTRACT TRUNCATED AT 250 WORDS)
Abstract 4503: Novel curcumin loaded magnetic nanoparticles for pancreatic cancer treatment.
Authors: Murali M. Yallapu, Mara C. Ebleling, Sheema Khan, Neeraj Chauhan, Brij K. Gupta, Vasudha Sundram, Meena Jaggi, Subhash C. Chauhan
Journal: Cancer Research (2013)

Abstract Curcumin (CUR), a naturally occurring polyphenol derived from the root of Curcuma longa, has demonstrated potent anti-cancer and cancer prevention activity in a variety of cancers. However, the clinical translation of curcumin has been significantly hampered due its extensive degradation, suboptimal pharmacokinetics and poor bioavailability. To address these clinically relevant issues, we have developed a novel curcumin loaded magnetic nanoparticle (MNP-CUR) formulation. Herein, we have evaluated the in vitro and in vivo therapeutic efficacy of this novel MNP-CUR formulation in pancreatic cancer. Human pancreatic cancer cells (HPAFII and Panc-1) exhibited efficient internalization of the MNP-CUR formulation in a dose dependent manner. As a result, MNP-CUR formulation effectively inhibited growth of HPAFII and Panc-1 cells in cell proliferation and colony formation assays. Similarly, the MNP-CUR formulation suppressed pancreatic tumor growth in an HPAFII xenograft mice model and improved mice survival by delaying tumor growth. The growth inhibitory effect of MNP-CUR formulation was correlated with the suppression of PCNA, Bcl-xL, Mcl-1, MUC1, collagen I and enhanced membrane β-catenin expression. Interestingly, our MNP-CUR formulation did not show any sign of hemotoxicity and stable after incubation with human serum proteins. Additionally, our MNP-CUR formulation improved serum bioavailability of curcumin in mice up to 2.5 fold as compared to curcumin in Tween-20. Furthermore, biodistribution studies of our MNP-CUR formulation demonstrate a significant amount of formulation was able to reach the pancreatic xenograft tumor(s) which suggests its clinical translational potential. In conclusion, our study suggests that our novel MNP-CUR formulation can be valuable for the treatment of pancreatic cancer. Citation Format: Murali M. Yallapu, Mara C. Ebleling, Sheema Khan, Neeraj Chauhan, Brij K. Gupta, Vasudha Sundram, Meena Jaggi, Subhash C. Chauhan. Novel curcumin loaded magnetic nanoparticles for pancreatic cancer treatment. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4503. doi:10.1158/1538-7445.AM2013-4503
Hyposensitization in nickel allergic contact dermatitis: Clinical and immunologic monitoring
Authors: Roger J.J. Troost, Martina M.A. Kozel, Cornelia G. van Helden-Meeuwsen, Theodoor van Joost, Paul G.H. Mulder, Robbert Benner, Errol P. Prens
Journal: Journal of the American Academy of Dermatology (1995)
Comparative Effectiveness Research
Authors: Robert M. Golub, Phil B. Fontanarosa
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stephen Wootton Bushell
Authors: Henry R. Viets
Journal: New England Journal of Medicine (1965)

STEPHEN Bushell, a graduate of the University of London in 1866, who served for thirty years as physician to the British legation in Peking, ultimately became the world authority on Chinese porcelain and pottery (Fig. 1). Few physicians have reached a more eminent position in a field other than their primary vocation, for Bushell's knowledge of Chinese literature and art, together with his fluency in the language, was unrivaled in his time. How this all came about is almost a unique story in the annals of medicine.Born in Ash-next-Sandwich, Kent, in 1844, Bushell obtained his preliminary education in a . . .
The Legal Status of Consent to Withhold Treatment-Reply
Authors: Judith Areen
Journal: JAMA (1987)

In Reply.—  Mr Scofield is certainly correct to emphasize that an individual who executes a living will should be as clear as possible about his or her wishes concerning treatment. Unfortunately, it is not easy to anticipate the variety of treatment choices that may arise. The problem with some living will statutes is not vagueness, moreover, but onerous procedural requirements. The most prudent course, therefore, may be to execute a durable power of attorney for health care and to provide the proxy selected with clear instructions about your preferences.  I also agree that there is a need for state legislation that specifies who is authorized to provide proxy consent in the absence of an advance directive, and thank Dr Palmisano for underscoring the point. As Mr Scofield's letter indicates, however, there is always the risk that state legislation will limit choice rather than merely clarify who is authorized to speak
Psychological and social problems in HIV infection: interviews with general practitioners in London.
Authors: M. B. King
Journal: BMJ (1989)

To assess current practice and opinions of general practitioners in London about managing psychological and social problems relating to HIV infection.A stratified random sample of general practitioners, including those with a range of experience of people with HIV infection, were interviewed by medically trained interviewers.Doctor's surgeries.270 General practitioners working within the area covered by London postcodes.Two thirds of doctors had treated at least one patient with HIV infection and described their work with these patients. General practitioners were counselling and educating many of their patients about AIDS and associated risk behaviours and were aware of the need for careful attention to confidentiality. Doctors with no experience of patients with HIV infection were often older, in singlehanded practice, less inclined to deal with drug abusers or to counsel their patients on risk behaviours, and more in favour of insurance companies' policies towards people with HIV infection.General practitioners in London are quickly becoming involved in the care of patients with HIV infection and their relatives and friends. Many are counselling patients and testing for antibodies themselves and regard this as an integral part of their work. A considerable workload in primary care comprised patients who obsessively fear contracting HIV infection.A random sample of 270 general practitioners in London was interviewed to assess current practice and opinions about managing psychological and social problems related to HIV infection. Physicians caring for patients with HIV infection were asked about numbers of patients in their pratice with HIV or AIDS; consultation with third parties such as sexual partners or family; reports to employers and other third parties; terminal care; contact with HIV clinics; testing for HIV infection without consent; and the impact of patients with HIV infection on their practice. All physicians were asked about patients concerned with HIV infection; awareness of other health resources for patients with HIV infection; terminal care; "safer sex" education; confidentiality; interest in AIDS; intravenous drug users as patients; managing homosexual patients; and ethical considerations. King discusses the findings and draws conclusions about primary care of HIV-infected patients in London.
Diet and New Lesions of the Coronary Arteries
Authors: Artemis P. Simopoulos
Journal: JAMA (1990)

To the Editor.—  In a recent issue of JAMA, Dr Blankenhorn et al 1 reported that increased intake of lauric, oleic, and linoleic acids significantly increased the risk of new atherosclerotic lesions over a 2-year period. The authors concluded that protein and carbohydrates are preferred substitutes for fat calories, rather than monounsaturated or polyunsaturated fat.  This is indeed a very important study, but the dietary data require further analysis to determine the intake of ω-3 fatty acids and the ratio of ω-6 to ω-3 fatty acids, in view of the finding that linoleic acid (an ω-6 fatty acid found in vegetable oils) significantly increased the risk of new atherosclerotic lesions. This, of course, is not entirely unexpected. Linoleic acid is metabolized to arachidonic acid, whose metabolites—prostaglandins, thromboxanes, and leukotrienes of the 2-series—have proaggregatory effects on platelets and promote thrombosis and chemotaxis of monocytes/macrophages, which contributes to the initial development
Release of Bound Antihuman Growth Hormone from Bovine Anterior Pituitary Polyribosomes by Ribonuclease and Hypothalamic Extract.
Authors: Roger M. Morrell
Journal: Annals of Internal Medicine (1969)

s1 May 1969Release of Bound Antihuman Growth Hormone from Bovine Anterior Pituitary Polyribosomes by Ribonuclease and Hypothalamic Extract.Roger M. Morrell, M.D.Roger M. Morrell, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1063_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe intracellular site and mode of action of hypothalamic releasing factors for anterior pituitary hormones are unknown. Labeled (125I)-rabbit-antihuman growth hormone (HGH) was incubated with bovine anterior pituitary supernatant and shown on sucrose density gradient analysis to have bound to a specific polyribosomal (polysomal) peak. The bound radioactivity was liberated into the ribosomal monomer peak by pancreatic ribonuclease that also abolished the polysomes. Treatment with ovine hypothalamic extract containing growth-hormone releasing factor (SRF) resulted in a shift of radioactivity into a different (soluble) portion of the gradient. The latter treatment left the polysomes intact, indicating minimal contamination with pancreatic ribonuclease.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Roger M. Morrell, M.D.Affiliations: Kalamazoo, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1063-1064KeywordsGrowth hormoneHuman growth hormoneProlactinSucrose ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
Gut Flora and Hepatic Encephalopathy in Patients with Cirrhosis
Authors: Stephen M. Riordan, Roger Williams
Journal: New England Journal of Medicine (2010)

Hepatic encephalopathy that is a complication of cirrhosis is not a uniform clinical entity; rather, it encompasses a spectrum of neuropsychiatric disturbances affecting motor function, cognition, personality, and consciousness.1 Clinical manifestations range from coma to subtle cognitive abnormalities detectable only on psychometric or neurophysiologic testing. The mild manifestation of hepatic encephalopathy, termed minimal hepatic encephalopathy, is estimated to affect up to 60% of patients with cirrhosis2 and may seriously impair a patient's daily functioning and quality of life. Psychomotor slowing and deficits in attention, visual perception, and visuoconstructive abilities are key features, whereas fine motor performance is also impaired. Minimal . . .
Why not color physicalism without color absolutism?
Authors: Zoltán Jakab, Brian P. McLaughlin
Journal: Behavioral and Brain Sciences (2003)

Abstract We make three points. First, the concept of productance value that the authors propose in their defense of color physicalism fails to do the work for which it is intended. Second, the authors fail to offer an adequate physicalist account of what they call the hue-magnitudes. Third, their answer to the problem of individual differences faces serious difficulties.
NORTON SCALE FOR PREDICTING PROGNOSIS IN ELDERLY PATIENTS UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION FOR ST ELEVATION MYOCARDIAL INFARCTION
Authors: Eran Leshem-Rubinow, Eyal Ben- Assa, Arie Steinvil, Arie Roth, Gad Keren, Dan Justo, Yacov Shacham
Journal: Journal of the American College of Cardiology (2015)
Gastric Cancer Mimicking Angiodysplasia
Authors: K. Kume, I. Yoshikawa, T. Myojo, M. Otsuki
Journal: Endoscopy (2004)

A 51-year-old Japanese man came to medical attention because of a routine stomach check-up. On endoscopy, angiodysplasia of the posterior wall of the cardia of the stomach was suspected (Figure [1]), and magnifying endoscopy with dye-spraying was done. A shallow recess with a small erosion in the center was observed and a biopsy was therefore taken (Figure [2]). The histological findings suggested well-differentiated tubular adenocarcinoma. Endoscopic ultrasonography showed only a thickening of the mucosal layer. Based on these findings, endoscopic mucosal resection (EMR) was carried out. The lesion was removed en bloc. The resected tumor was 9 × 8 mm and histological examination revealed well-differentiated tubular adenocarcinoma limited to the mucosal layer.
Ventricular Fusion Beats
Authors: Yu-Chen Lee
Journal: JAMA (1967)

<h3>To the Editor:—</h3> The patient reported by me (<b>201</b>:566, 1967) had persistent complete AV block, with idioventricular rhythm for more than six months before he entered the hospital. At no time did the electrocardiograms show conducted beats. The pacemaker of the idioventricular rhythm apparently shifted from time to time. The accompanying tracings recorded on Nov 3, 1966 (Figure, top) and Nov 8 (Fig, bottom) illustrate this point. The ventricular rate in both instances was about 30 per minute. Two idioventricular pacemakers, having similar rates and firing almost synchronously, have been reported.<sup>1</sup>Mild irregularity of the QRS intervals is not uncommon in idioventricular rhythm. Slight delay of the pacemaker responsible for the right bundle-branch type QRS configuration after the eighth beat resulted in a shift of the pacemaker to that producing the other type of QRS configuration. All the evidence indicates that the rhythm illustrated in the report, "Ventricular
Five year outcomes in a cohort study of physicians treated for substance use disorders in the United States
Authors: A T. McLellan, G. S Skipper, M. Campbell, R. L DuPont
Journal: BMJ (2008)

<b>Objective</b> To evaluate the effectiveness of US state physician health programmes in treating physicians with substance use disorders. <b>Design</b> Five year, longitudinal, cohort study. <b>Setting</b> Purposive sample of 16 state physician health programmes in the United States. <b>Participants</b> 904 physicians consecutively admitted to one of the 16 programmes from September 1995 to September 2001. <b>Main outcome measures</b> Completion of the programme, continued alcohol and drug misuse (regular urine tests), and occupational status at five years. <b>Results</b> 155 of 802 physicians (19.3%) with known outcomes failed the programme, usually early during treatment. Of the 647 (80.7%) who completed treatment and resumed practice under supervision and monitoring, alcohol or drug misuse was detected by urine testing in 126 (19%) over five years; 33 (26%) of these had a repeat positive test result. At five year follow-up, 631 (78.7%) physicians were licensed and working, 87 (10.8%) had their licences revoked, 28 (3.5%) had retired, 30 (3.7%) had died, and 26 (3.2%) had unknown status. <b>Conclusion</b> About three quarters of US physicians with substance use disorders managed in this subset of physician health programmes had favourable outcomes at five years. Such programmes seem to provide an appropriate combination of treatment, support, and sanctions to manage addiction among physicians effectively.
Enhanced Detectability of Local Colloid Uptake with SPECT Imaging
Authors: DONALD A. PODOLOFF, E EDMUND KIM
Journal: Clinical Nuclear Medicine (1988)

Focal “hot” spots with Tc-99m sulfur colloid in the left lobe of the liver have been reported in a variety of conditions. SPECT imaging of the liver has demonstrated increased accuracy of detecting small sized hemangiomas. A case is presented in which the SPECT images clearly demonstrate a “hot” spot in the left lobe of the liver that is not well demonstrated on planar imaging. There is little information regarding the enhanced detectability of left lobe “hot” spots with SPECT imaging. This case demonstrates such findings.
Lack of Association of a New LTC4S Promoter Polymorphism (−1702G&gt;A) with Aspirin-Intolerant Asthma (AIA)
Authors: J.H. Choi, J.S. Bae, S.H. Kim, C.H. Suh, D.H. Nahm, H.S. Park
Journal: Journal of Allergy and Clinical Immunology (2006)
Hypothalamic-pituitary dysfunction in respiratory hypoxia.
Authors: P D Semple, G H Beastall, W S Watson, R Hume
Journal: Thorax (1981)

Eight hypoxic male patients with stable chronic obstructive airways disease were submitted for combined anterior pituitary function testing. All subjects showed normal growth hormone and essentially normal cortisol responses to adequate hypoglycaemia, two subjects showed delayed responses of thyroid stimulating hormone to administered thyrotrophin releasing hormone and all had basal prolactin levels within normal limits. Basal levels of luteinising hormone were significantly lower than in the group of age-matched controls (p less than 0.02) but there was a normal increment after the injection of gonadotrophin releasing hormone. Basal levels of follicle stimulating hormone were significantly lower than in the controls (p less than 0.01), and there was also a reduced response from the pituitary after injection of gonadotrophin releasing hormone (p less than 0.01). Resting levels of the thyroid hormones thyroxine and tri-iodothyronine were normal while the expected subnormal testosterone level was observed (p less than 0.05). These results show that hypoxia can produce abnormalities of hypothalamic-pituitary function and that these are primarily located in the hypothalamic-pituitary-testicular axis.
Gastroduodenal Artery Aneurysm Detected by Radionuclide Studies
Authors: PILAR ORELLANA, ENRIQUE OLEA, RICARDO LILLO, JORGE HERSKOVIC, JUAN KAPPES, MANUEL FERN??NDEZ, PATRICIO GONZ??LEZ
Journal: Clinical Nuclear Medicine (1983)

The value of Ga-67 images in identifying unsuspected locations of subcutaneous Staphylococcus aureus abscess is presented. Many of the lesions detected on the Ga-67 study were not clinically evident. In addition, follow-up studies show resolution of the changes after antibiotic therapy.
MD-Challenger: Clinical Reference and Educational Software for Acute Care and Emergency Medicine
Authors: John H. van de Leuv
Journal: JAMA (1994)

As its name indicates,<i>MD-Challenger</i>is indeed a challenge. It is both a clinical reference, as the subtitle indicates, and a challenging testing tool. Common concerns with software are ease of setup and ability to move around in the program.<i>MD-Challenger</i>is exceptionally easy to set up. It is also easy to run, if the operator takes a few minutes to read the short guide and tours the program through its tutorial. Essentially,<i>MD-Challenger</i>is easy to use. The program itself is divided into chapters, each dealing with a specialty or subspecialty. The number of questions varies from chapter to chapter, from 23 in "Immunology, Allergy and Rheumatology" to 501 in the trauma chapter. It is possible to roam from chapter to chapter, although the editors recommend finishing one chapter before attempting the next. One must identify oneself at the onset and provide a password. This allows scorekeeping. The scoring