Neonatal Graves' Disease
Authors: RICHARD A. HOLMES
Journal: Annals of Internal Medicine (1965)

Case Studies1 May 1965Neonatal Graves' DiseaseRICHARD A. HOLMES, M.D., NORMAN H. ENGBRING, M.D., WILLIAM W. ENGSTROM, M.D.RICHARD A. HOLMES, M.D.Search for more papers by this author, NORMAN H. ENGBRING, M.D.Search for more papers by this author, WILLIAM W. ENGSTROM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1008 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince publication of C. H. Parry's original description of hyperthyroidism in 1825 (1), little attention has been given to neonatal hyperthyroidism until recently. White, in 1912, recorded the first case (2), and since that time less than 30 cases have been added. The infrequent occurrence generally is attributed either to the infertility or to the rarity of viable pregnancies in thyrotoxic women. Hyperthyroidism in these instances is almost invariably a part of Graves' disease. Although the pathogenesis of Graves' disease remains obscure, a long-acting thyroid stimulating substance (LATS), initially described by Adams (3), has been implicated as a possible etiological...References1. PARRY CH: Collections from the Unpublished Papers of the Late Caleb Hilliel Parry, Vol. 2, London, 1825, p. 111. Google Scholar2. WHITE C: A foetus with congenital hereditary Graves' disease. J. Obstet. Gynaec. Brit. Comm. 21: 231, 1912. CrossrefGoogle Scholar3. ADAMS DD: The presence of an abnormal thyroid stimulating hormone in the serum of some thyrotoxic patients. J. Clin. Endocr. 18: 699, 1958. CrossrefGoogle Scholar4. MCKENZIE JM: Neonatal Graves' disease. J. Clin. Endocr. 24: 660, 1964. CrossrefMedlineGoogle Scholar5. MCKENZIE JM: Delayed thyroid response to serum from thyrotoxic patients. Endocrinology 62: 865, 1958. CrossrefMedlineGoogle Scholar6. MCKENZIE JM: The bioassay of thyrotropin in serum. Endocrinology 63: 372, 1958. CrossrefMedlineGoogle Scholar7. ASTWOOD EB: The use of anti-thyroid drugs during pregnancy. J. Clin. Endocr. 11: 1045, 1951. CrossrefGoogle Scholar8. BONCIOVANNIEBERLEINTHOMASANDERSON AMWRPZWB: Sporadic goiter of the newborn. J. Clin. Endocr. 16: 146, 1956. CrossrefGoogle Scholar9. HAWEFRANCIS PHH: Pregnancy and thyrotoxicosis. Brit. Med. J. 2: 817, 1962. CrossrefMedlineGoogle Scholar10. GRUMBACHWERNER MMSC: Transfer of thyroid hormone across the placenta at term. J. Clin. Endocr. 16: 1392, 1956. CrossrefGoogle Scholar11. FISHERLEHMANLACKEY DAHC: Placental transport of thyroxine. J. Clin. Endocr. 24: 393, 1964. CrossrefGoogle Scholar12. LONDONMONEYRAWSON WTWLRW: Placental transport of I131 labeled thyroxine and triiodothyronine in the guinea pig. Endocrinology 73: 205, 1963. CrossrefMedlineGoogle Scholar13. ROYKOBAYASHI SKY: Placental transfer of 1-thyroxine and triiodo-1-thyronine in rats during late pregnancy. Proc. Soc. Exp. Biol. Med. 110: 699, 1962. CrossrefMedlineGoogle Scholar14. FRENCHVAN WYK FSJJ: Fetal hypothyroidism. J. Pediat. 64: 589, 1964. CrossrefMedlineGoogle Scholar15. JAVETTSENIORBRAUDOHEYMANN SNBJLS: Neonatal thyrotoxicosis. Pediatrics 24: 65, 1959. MedlineGoogle Scholar16. CARRBEIRWALTES EAWH: The effect of maternal thyroid function on fetal thyroid and development. J. Clin. Endocr. 52: 705, 1953. Google Scholar17. MCKENZIE JM: Bio-assay of thyrotropin in man. Physiol. Rev. 40: 398, 1960. CrossrefGoogle Scholar18. PETERSONYOUNG RRWC: The problem of placental permeability for thyrotropin, propylthiouracil, and thyroxine in the guinea pig. Endocrinology 50: 218, 1952. CrossrefMedlineGoogle Scholar19. YAMAZAKINOGUCHISINGERLAND EADW: Thyrotropin in serum of mother and fetus. J. Clin. Endocr. 21: 1013, 1961. CrossrefGoogle Scholar20. PARKINSGREENE GJA: Pregnancy occurring in cretinism, and in juvenile and adult myxedema. J. Clin. Endocr. 3: 466, 1943. CrossrefGoogle Scholar21. HODGESHAMILTONKEETTEL REHEWC: Pregnancy in myxedema. Arch. Intern. Med. (Chicago) 90: 863, 1952. CrossrefGoogle Scholar22. KOERNER KA: Congenital goiter with exophthalmos and hyperthyroidism. J. Pediat. 45: 464, 1954. CrossrefMedlineGoogle Scholar23. KEYNES G: Obstetrics and gynaecology in relation to thyrotoxicosis and myasthenia gravis. J. of Obstet. Gynaec. Brit. Comm. 59: 173, 1952. CrossrefGoogle Scholar24. RILEYSCLARE IDG: Thyroid disorders in the newborn. Brit. Med. J. 1: 979, 1957. CrossrefMedlineGoogle Scholar25. HERBSTSELENKOW ALHA: Combined anti-thyroid therapy of hyperthyroidism in pregnancy. Obstet. Gynec. 21: 543, 1963. Google Scholar26. PARISMCCONAHEYOWEN JWMCA: Iodide goiter. J. Endocr. 20: 57, 1960. Google Scholar27. GALINAAVNETEINHORN MPNLA: Iodides during pregnancy. New Eng. J. Med. 267: 1124, 1962. CrossrefMedlineGoogle Scholar28. MCKENZIE JM: Studies on the thyroid activator of hyperthyroidism. J. Clin. Endocr. 21: 635, 1961. CrossrefGoogle Scholar29. ADAMSKENNEDY DDTH: Association of long acting thyroid stimulator with the gamma globulin fraction of serum. Proc. Univ. Otago Med. Sch. 40: 6, 1962. Google Scholar30. MCKENZIE JM: Further evidence for a thyroid activator in hyperthyroidism. J. Clin. Endocr. 20: 380, 1960. CrossrefGoogle Scholar31. NOGUCHIKURIHARASATO AHS: Clinical studies on the long-acting thyroid stimulator. J. Clin. Endocr. 24: 160, 1964. CrossrefGoogle Scholar32. BATESGARRISONHOWARD RWMMTB: Extraction of thyrotropin from pituitary glands, mouse pituitary tumors and blood plasma by percolation. Endocrinology 65: 7, 1959. CrossrefMedlineGoogle Scholar33. MCKENZIEFISHMAN JMJ: Effects of antiserum in bioassay of thyrotropin and thyroid activator of hyperthyroidism. Proc. Soc. Exp. Biol. Med. 105: 126, 1960. CrossrefMedlineGoogle Scholar34. FAJANS SS: Hyperthyroidism in a patient with post-partum necrosis of the pituitary: case report and implications. J. Clin. Endocr. 18: 271, 1958. CrossrefGoogle Scholar35. WERNERSTEWART SCWB: Hyperthyroidism in a patient with a pituitary chromophobe adenoma and a fragment of normal pituitary. Ibid., p. 266. Google Scholar36. ROSENBERGGRANDSILBERT DMJD: Neonatal hyperthyroidism. New Eng. J. Med. 268: 292, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Milwaukee, WisconsinFrom the Department of Medicine, Marquette University School of Medicine and Milwaukee County General Hospital, Milwaukee, Wisc.This study was supported in part by grants 5T1-AM-5023-10, R01-AM-08932-01END, and AM-01200-12 from the U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Richard A. Holmes, M.D., Milwaukee County General Hospital, 8700 W. Wisconsin Avenue, Milwaukee, Wisc. 53226. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByImmunological Aspects of DevelopmentNeonatal hypothyroidism and goiter in oneinfant of each of two sets of twins due to maternal therapy with antithyroid drugsHereditary aspects of Graves' disease in infancy and childhoodLymphocytic Thyroiditis and ThyrotoxicosisFamilial hyperthyroidism including two siblings with neonatal Graves' diseaseThe Effect of Immune Reactions on Fetal DevelopmentThe Long-Acting Thyroid StimulatorMechanisms of Graves' Disease and Endocrine ExophthalmosThe Nature and Significance of the Long-Acting Thyroid Stimulator 1 May 1965Volume 62, Issue 5Page: 1008-1013KeywordsHospital medicineHyperthyroidismInfantsInfertilityMedical servicesObstetrics and gynecologyPathogenesisPediatricsPregnancyThyroid Issue Published: 1 May 1965 PDF DownloadLoading ...