tbuckley/cabot-search huggingface dataset:
Hereditary Spherocytosis with Fatal Complications
Authors: THOMAS W. GREEN
Journal: Annals of Internal Medicine (1961)

Case Reports1 July 1961Hereditary Spherocytosis with Fatal ComplicationsNecessity of Elective Splenectomy Early in the DiseaseTHOMAS W. GREEN, M.D., WAVERLY S. GREEN JR., M.D.THOMAS W. GREEN, M.D.Search for more papers by this author, WAVERLY S. GREEN JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-1-155 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHereditary spherocytosis is a disease characterized by the inherited abnormality of spherocytic red cells, associated with varying degrees of hemolytic anemia and jaundice. Splenectomy in this disorder is usually effective in causing a cessation of the excessive red cell destruction and relieving the anemia and jaundice. If it is performed early in the course of the disease subsequent disability, including biliary tract complications, is eliminated. It is generally agreed that splenectomy is necessary when anemia, jaundice, and hemolytic or aplastic crises are troublesome (1). However, it has not been emphasized that complications of this disease may shorten life expectancy, and...References1. WINTROBE MM: Clinical Hematology, 4th Ed., Lea & Febiger, Philadelphia, 1956, p. 662. Google Scholar2. HARRISON TR: Principles of Internal Medicine, 3rd Ed., McGraw-Hill Book Company, Inc., New York, 1958, p. 1477. Google Scholar3. THOMPSONHOWARDVOWLES JAJMKD: Acute pancreatitis following choledochotomy. Surg., Gynec. Obstet. 105: 706, 1957. MedlineGoogle Scholar4. WARRENCATELL KWRB: Pancreatic surgery. New Engl. J. Med. 261: 333, 1959. CrossrefMedlineGoogle Scholar5. HUNTLEY CC: Infection following splenectomy in infants and children. Amer. J. Dis. Child. 95: 477, 1958. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: THOMAS W. GREEN, M.D.; WAVERLY S. GREENJR., M.D.Affiliations: Bristol, TennesseeReceived for publication April 4, 1960.Requests for reprints should be addressed to Thomas W. Green, M.D., Suite 3-H, Doctors' Building, Bristol, Tenn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMedical genetics 1961 1 July 1961Volume 55, Issue 1Page: 155-157KeywordsAnemiaBileBiliary systemCellsDisabilitiesGenetic diseasesHemolytic anemiaLife expectancyPancreatitisSplenectomy ePublished: 1 December 2008 Issue Published: 1 July 1961 PDF downloadLoading ...
B cell-activating Factor of the TNF Family (BAFF) Expression in Chronic Rhinosinusitis with Nasal Polyps
Authors: R.P. Schleimer, A. Kato, A. Tripathi, B. Tancowny, L. Suh, R. Carter, M. Agashe, K.E. Harris, D. Conley, R. Kern, L.C. Grammer
Journal: Journal of Allergy and Clinical Immunology (2007)
The effect of adenovirus-conjugated NDRG2 on p53-mediated apoptosis of hepatocarcinoma cells through attenuation of nucleotide excision repair capacity
Authors: Wei Cao, Ju-liang Zhang, Da-yun Feng, Xue-wu Liu, Yan Li, Li-feng Wang, Li-bo Yao, Hongxin Zhang, Jian Zhang
Journal: Biomaterials (2013)
THE EFFECT OF EDUCATIONAL LECTURE ON REDUCING REINJURY AFTER ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION
Authors: K Sato, A Tsuchiya, I Kanisawa, K Takahashi, H Sakai, T Nagamine
Journal: British Journal of Sports Medicine (2014)

Background Although anterior cruciate ligament (ACL) injury prevention programs have been published, little is known about ACL reinjury prevention after ACL reconstruction. On the other hand, we have held educational lectures for patients before undergoing ACL reconstruction. Objective The objective of this study was to determine if this lecture was effective in reducing the reinjury rate. Design Retrospective cohort study. Setting Clinical setting with competitive and recreational athletes. Participants 452 patients that underwent anatomical double-bundle ACL reconstruction using hamstring tendons in our hospital between 2010 and 2012, participated in this study. Exclusion criteria consisted of bilateral ACL injuries and revision surgery. Two hundred fifty two patients (122 men, 130 women, mean age=27.8 years) who attended the lecture were defined as the intervention group. Two hundred patients (118 men, 82 women, mean age=26.5 years) who didn't attend the lecture were defined as the control group. Intervention Knee anatomy, operative procedure, postoperative rehabilitation, and risk of reinjury were explained in the two hour lecture. Main outcome measures Standard reinjury rate and the reinjury rate within one year after surgery were investigated and compared between the groups using the chi-square test (P&lt;.05). Results Reinjury occurred in 8 patients (3.2%) in the intervention group, and 9 patients (4.5%) in the control group. No significant difference between the groups was observed. Reinjury within one year after surgery occurred in 3 patients (1.2%) in the intervention group, and 9 patients (4.5%) in the control group. There was a significant difference between the groups (P=.029). Conclusion Although no statistical difference in reinjury rate was observed between groups, the patients who attended the lecture had significantly lower rate of reinjury within one year after surgery than the patients who did not.
Focus: Westminster Labour would freeze funds for NHS
Authors: J. Warden
Journal: BMJ (1997)

The House of Commons spent almost nine hours last week debating aspects of the National Health Service. It arose in adjournment debates, at prime minister's questions, and in an opposition motion. Background buzz of an early general election made the connection a depressingly obvious indication of what lies ahead.

There was also the irony of sick MPs being wheeled in to vote ostensibly on health but in reality to save the government. The government's majority in the house now comes and goes with the mortality of MPs. Ahead of the health debate it was zero, dropped to minus one when a Conservative MP died, but returned …
Evaluation of Acromegaly by Radioimmunoassay of Somatomedin-C
Authors: D R Clemmons, J J Van Wyk, E C Ridgway, B Kliman, R N Kjellberg, L E Underwood
Journal: New England Journal of Medicine (1979)

We measured serum concentrations of somatomedin-C by radioimmunoassay in 57 acromegalic patients and compared them with various indicators of disease activity. The mean fasting somatomedin-C concentration was 6.8 U per milliliter (range, 2.6 to 21.7) for the acromegalics and 0.67 U per milliliter (range, 0.31 to 1.4) for 48 normal, fasting adults. The somatomedin-C concentration correlated significantly with: heel-pad thickness (r = 0.73), fasting glucose (r = 0.74), and one-hour postprandial glucose (r = 0.77). In contrast, "glucose-suppressed" growth hormone correlated weakly (r = 0.34, 0.36, 0.34) with these clinical indexes of severity. Fasting growth hormone levels showed no correlation (r = 0.14). Five active acromegalics had "normal" growth hormone levels after glucose suppression, but they had elevated somatomedin-C. In 15 patients studied one year after treatment, changes in somatomedin-C concentrations paralleled the degree of clinical improvement. Measurement of somatomedin-C appears to provide a reliable means for confirming the diagnosis of acromegaly and of clinical disease activity than measurement of growth hormone concentrations.
Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization
Authors: Nicolas Rama, Alexandre Dubrac, Thomas Mathivet, Róisín-Ana Ní Chárthaigh, Gael Genet, Brunella Cristofaro, Laurence Pibouin-Fragner, Le Ma, Anne Eichmann, Alain Chédotal
Journal: Nature Medicine (2015)
A NEW DEVICE FOR TESTING THE COLOR SENSE
Authors: Walter G. Nelson
Journal: JAMA (1925)

For the last five years, part of my duties has been the examination of the color sense of applicants for various government services. Williams' lantern and the color skeins have both been employed and are still used. However, I have felt that the color skeins have certain disadvantages; among them, the length of time involved in giving the test, the fact that the loose skeins are apt to be misplaced or lost and also the fact that they are apt to become soiled, thus further confusing the applicant. About two and a half years ago, I devised a scheme that I think has all the advantages of the color skein system without most of the disadvantages. I have termed the test the "color wheel test," because of its construction. The device has compactness, being 15 inches square and about 2 inches high at its highest point. It also has permanency,
José Gay Prieto
Authors: Leyre A. Falto-Aizpurua, Brian J. Simmons, Robert D. Griffith, Fleta N. Bray, Keyvan Nouri
Journal: JAMA Dermatology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Pulmonary hypertension in hypoventilation syndromes
Authors: R. Naeije
Journal: European Respiratory Journal (2013)

The object that presented itself to the eyes of the astonished clerk, was a boy – a wonderfully fat boy – habited as a serving lad, standing upright on the mat, with his eyes closed as if in sleep. 

– Dickens [1]

In this issue of the European Respiratory Journal , Held et al. [2] report on 18 patients with severe pulmonary hypertension due to alveolar hypoventilation, who were markedly improved after 3 months of noninvasive bi-level positive-pressure ventilation (NIPPV). Mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR) were 50 mmHg and 6–7 Wood units, respectively, at baseline, and decreased to 30 mmHg and 3–4 Wood units with NIPPV; this was accompanied by improved catherisation and echocardiographic indices of right ventricular (RV) function. The N-terminal pro-brain natriuretic peptide (NT-proBNP) levels also decreased, and the 6-min walk distance (6MWD) improved by 80 m. These results are in striking contrast with the “borderline” (mPAP 20–25 mmHg) or mild (mPAP 25–30 mmHg) pulmonary hypertension generally seen, but with rare exceptions, in patients with respiratory conditions. Borderline or mild pulmonary hypertension due to respiratory conditions is of uncertain clinical relevance, exhibits slow progression controlled by supplemental oxygen and is refractory to drugs targeting the pulmonary circulation [3, 4].

12 of the 18 patients reported by Held et al. [2] fulfilled the criteria of obesity hypoventilation syndrome (OHS), defined by a combination of awake hypercapnia (arterial carbon dioxide tension ( P aCO2) >45 mmHg), a body mass index >30 kg·m−2 and exclusion of other causes that could account for hypoventilation, such as lung or neuromuscular disease [5, 6]. Three of the OHS patients had concomitant chronic obstructive pulmonary disease (COPD) and five patients had COPD without obesity. …
Detection of Impending Pericardial Tamponade During Skeletal Imaging
Authors: CLAUDIA M. ENGELER, REN?? P. DUCRET, VALERIE ULSTAD, MARK MAHAN, CHRISTOPHER C. KUNI, ROBERT J. BOUDREAU
Journal: Clinical Nuclear Medicine (1989)

Bone imaging using Tc-99m MDP was performed on a 68-year-old man with a newly diagnosed adenocarcinoma of the lung. The image unexpectedly showed increased activity in the heart area. Emergent echocardiography demonstrated impending pericardial tamponade. A malignant pericardial effusion was verified by pericardiocentesis.
A population-based study of the incidence of delusional infestation in Olmsted County, Minnesota, 1976-2010
Authors: C.H. Bailey, L.K. Andersen, G.C. Lowe, M.R. Pittelkow, J.M. Bostwick, M.D.P. Davis
Journal: British Journal of Dermatology (2014)

Delusional infestation (DI) is a well-recognized clinical entity but there is a paucity of reliable data concerning its epidemiology. Knowledge of the epidemiology is fundamental to an understanding of any disease and its implications. Epidemiology is most accurately assessed using population-based studies, which are most generalizable to the wider population in the U.S. and worldwide. To our knowledge, no population-based study of the epidemiology (particularly incidence) of DI has been reported to date.To determine the incidence of delusional infestation (DI) using a population-based study.Medical records of Olmsted County residents were reviewed using the resources of the Rochester Epidemiology Project to confirm the patient's status as a true incident case of DI and to gather demographic information. Patients with a first-time diagnosis of DI or synonymous conditions between 1 January 1976 and 31 December 2010 were considered incident cases.Of 470 identified possible diagnoses, 64 were true incident cases of DI in this population-based study. The age- and sex-adjusted incidence was 1·9 [95% confidence interval (CI) 1·5-2·4] per 100 000 person-years. Mean age at diagnosis was 61·4 years (range 9-92 years). The incidence of DI increased over the four decades from 1·6 (95% CI 0·6-2·6) per 100 000 person-years in 1976-1985 to 2·6 (95% CI 1·4-3·8) per 100 000 person-years in 2006-2010.Our data indicate that DI is a rare disease, with incidence increasing across the life span, especially after the age of 40 years.
Mortality of Mexican Americans With NIDDM: Retinopathy and other predictors in Starr County, Texas
Authors: Craig L Hanis, Hsuan-Ho Chu, Kim Lawson, David Hewett-Emmett, Sara A Barton, William J Schull, Charles A Garcia
Journal: Diabetes Care (1993)

To determine the rate and risk factors of mortality in a cohort of Mexican Americans with NIDDM.A cohort of 353 Mexican Americans with NIDDM were identified between 1981 and 1986. All individuals underwent extensive evaluations that included physical, historical, ophthalmological, and laboratory assessments. This cohort was followed prospectively for a mean of 8 yr. Follow-up included mortality surveillance, death certificate extraction, and a combination of annual and intermediate examinations.The cohort experienced 67 mortality events. One-third of all deaths were premature < 65 yr of age) and most often were attributed to diseases of the heart (60.0%). In no case was diabetes listed as the cause of death, although it was listed as a contributing cause in 25.5% of cases. Men had a higher mortality rate than women. In both sexes, baseline retinopathy was identified as an important predictor of subsequent mortality. Mortality was significantly elevated in those with nonproliferative retinopathy and even further elevated in those with proliferative disease (relative risks of > or = 4 for proliferative disease).Mexican Americans with NIDDM are experiencing premature and excessive mortality compared with the general population. The results clearly link microvascular complications with macrovascular disease, but this link is not explained by a more untoward profile of traditional cardiovascular risk factors. Retinopathy appears to serve as an important monitor of the progression of diabetes and when identified would warrant aggressive action to inhibit or slow the processes leading to subsequent mortality.
Hospitalization Costs Associated with Homelessness in New York City
Authors: Sharon A. Salit, Evelyn M. Kuhn, Arthur J. Hartz, Jade M. Vu, Andrew L. Mosso
Journal: New England Journal of Medicine (1998)

Homelessness is believed to be a cause of health problems and high medical costs, but data supporting this association have been difficult to obtain. We compared lengths of stay and reasons for hospital admission among homeless and other low-income persons in New York City to estimate the hospitalization costs associated with homelessness.
Structural Abnormalities of Great Arterial Walls in Congenital Heart Disease
Authors: Koichiro Niwa, Joseph K. Perloff, Sunita M. Bhuta, Hillel Laks, Davis C. Drinkwater, John S. Child, Pamela D. Miner
Journal: Circulation (2001)

Background —Great arteries in congenital heart disease (CHD) may dilate, become aneurysmal, or rupture. Little is known about medial abnormalities in these arterial walls. Accordingly, we studied 18 types of CHD in patients from neonates to older adults. Methods and Results —Intraoperative biopsies from ascending aorta, paracoarctation aorta, truncus arteriosus, and pulmonary trunk in 86 patients were supplemented by 16 necropsy specimens. The 102 patients were 3 weeks to 81 years old (average, 32±6 years). Biopsies were examined by light (LM) and electron (EM) microscopy; necropsy specimens by LM. Positive aortic controls were from 15 Marfan patients. Negative aortic controls were from 11 coronary artery disease patients and 1 transplant donor. Nine biopsies from acquired trileaflet aortic stenosis were compared with biopsies from bicuspid aortic stenosis. Negative pulmonary trunk controls were from 7 coronary artery disease patients. A grading system consisted of negative controls and grades 1, 2, and 3 (positive controls) based on LM and EM examination of medial constituents. Conclusions —Medial abnormalities in ascending aorta, paracoarctation aorta, truncus arteriosus, and pulmonary trunk were prevalent in patients with a variety of forms of CHD encompassing a wide age range. Aortic abnormalities may predispose to dilatation, aneurysm, and rupture. Pulmonary trunk abnormalities may predispose to dilatation and aneurysm; hypertensive aneurysms may rupture. Pivotal questions are whether these abnormalities are inherent or acquired, whether CHD plays a causal or facilitating role, and whether genetic determinants are operative.
STUDIES ON BARTONELLA MURIS ANEMIA OF ALBINO RATS
Authors: J. Marmorston-Gottesman, David Perla
Journal: The Journal of Experimental Medicine (1930)

1. The virus of Bartonella muris anemia of splenectomized rats may be transmitted to normal young unoperated rats and rabbits. This confirms the observations of Ford and Eliot. 2. Trypanosoma lewisi infections in normal adult rats are accompanied by an anemia most marked at the height of the infection and the appearance of Bartonella muris bodies in the red blood cells. 3. In young rats Trypanosoma lewisi may produce death from the severity of the anemia, complicating the disease. The anemic virus may be separated from the Trypanosoma lewisi infected blood by passage through young rabbits with subsequent maintenance of the strain in immature rats. 4. A strain of the virus of Bartonella muris anemia capable of producing an anemia in young rabbits and young rats for successive transfers has been isolated from the blood of normal adult unoperated rats by passage through young rabbits. 5. The adult normal rat is a carrier of the Bartonella muris virus. 6. Splenectomy in young suckling rats separated from the mother is not followed by a Bartonella muris anemia. The young suckling rat is not a carrier of the infection.
Oral bolus of IC antiarrhythmic drugs for atrial fibrillation: Outpatient versus inpatient administration
Authors: Nassir F. Marrouche, Johannes Brachmann, Jens Guenther, Volker Schibgilla, Walid Saliba, Gery Tomassoni, Salwa Beheiry, Ennio Pisano, Dianna Bash
Journal: Journal of the American College of Cardiology (2003)
Practice Expenses and Ancillary Help
Authors: D. G. Barrowcliffe
Journal: BMJ (1964)

BRyUHdoctor with 3,000 patients has not been subsidizing the doctor with 1,500 patients- rather the reverse.If a direct payment for ancillary help is given to the doctor with 3,000 patients (that is the doctor with ancillary help) it would result in the small-list doctor without ancillary help subsidizing still more the large- list doctor.For this reason, the present pro- posed scheme should definitely be abandoned as being inequitable, and perhaps a scheme fairer to all could be evolved.If not, I should leave well alone, as the large-list doctor is already receiving higher practice expenses, with which he can pay for his ancillary help.-Iam, etc., Glasgow S.i.
Genetic origins and clinical phenotype of familial and acquired erythrocytosis and thrombocytosis
Authors: Melanie J. Percy, Elisa Rumi
Journal: American Journal of Hematology (2008)

Abstract Familial and acquired erythrocytosis and thrombocytosis are characterized by myeloid lineage hyperproliferation, which is either single or multi‐lineage in origin. The single lineage disorders exhibit Mendelian inheritance with polyclonal hematopoiesis and often arise from a single genetic defect. In contrast, the multi‐lineage disorders exhibit complex patterns of inheritance with multi‐genetic origins and clonal hematopoiesis. They have the potential to acquire JAK2 somatic mutations, but this is not the primary event. Identification of the disease‐causing genes will enable better classification of familial and acquired erythrocytosis and thrombocytosis. Furthermore, it will provide an insight into the mechanisms regulating myeloid cell proliferation. Am. J. Hematol., 2009. © 2008 Wiley‐Liss, Inc.
Prevalence and Characteristics of Early Repolarization in the CASPER Registry
Authors: Nicolas Derval, Christopher S. Simpson, David H. Birnie, Jeffrey S. Healey, Vijay Chauhan, Jean Champagne, Martin Gardner, Shubhayan Sanatani, Raymond Yee, Allan C. Skanes, Lorne J. Gula, Peter Leong-Sit, Kamran Ahmad, Michael H. Gollob, Michel Haïssaguerre, George J. Klein, Andrew D. Krahn
Journal: Journal of the American College of Cardiology (2011)
Colchicine Can Treat Full Range of Pericarditis
Authors: Anita Slomski
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal