Antidiuretic Hormone Syndrome and Thioridazine
Authors: FREDERICK M. VINCENT
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 July 1978Antidiuretic Hormone Syndrome and ThioridazineFREDERICK M. VINCENT, M.D., SCOTT EMERY, M.D.FREDERICK M. VINCENT, M.D.Search for more papers by this author, SCOTT EMERY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-1-147_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article "Inappropriate Antidiuresis During Carbamazepine Treatment" (Ann Intern Med 87:722-723, 1977) warns us of a potentially serious complication of a fairly widely used medication. We wish to report the case of a psychiatric patient who developed the syndrome of inappropriate antidiuretic hormone secretion (SIADH) after the administration of thioridazine (Mellaril®).A 58-year-old woman was admitted to the hospital for treatment of her chronic depression. She was taking amitriptyline hydrochloride, 150 mg daily. On admission her blood urea nitrogen (BUN) was 9 mg/dl; serum sodium concentration, 139 meq/litre; and urine specific gravity, 1.012. Her amitriptyline dosage was...References1. RAOMILLERMOSES KMA: Water intoxication and thioridazine (Mellaril®). Ann Intern Med 82:61, 1975 LinkGoogle Scholar2. LUZECKYBURMANSCHULTZ MKE: The syndrome of inappropriate antidiuretic hormone secretion associated with amitriptyline administration. South Med J 67:495-497, 1974 CrossrefMedlineGoogle Scholar3. RASKINDWEITZMANORENSTEIN MRH: Presented at the 130th annual meeting of the American Psychiatric Association, Toronto, 5 May 1977 Google Scholar4. NARANGCHADHURYWIG RRN: Effect of electroconvulsive therapy on the antidiuretic hormone level in the plasma of schizophrenic patients. Indian J Med Res 61:766-770, 1973 MedlineGoogle Scholar5. DYBALL R: The effects of drugs on the release of vasopressin. Br J Pharmacol Chemother 33:329-341, 1968 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Dartmouth-Hitchcock Medical Center Hanover, NH 03755 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDisorders of Sodium and Water BalanceHyponatremia Induced by DrugsHyponatraemia as an Adverse Drug Reaction of Antipsychotic DrugsAntipsychotic-Induced HyponatraemiaA Review of Drug-Induced HyponatremiaHyponatraemia Associated with Psychotropic MedicationsExcessive water drinking behavior in autismTHE SIDE-EFFECTS OF ANTIPSYCHOTIC DRUGS. II. EFFECTS ON OTHER PHYSIOLOGICAL SYSTEMSSyndrome of inappropriate secretion of antidiuretic hormone associated with schizophreniaLong-term neurologic outcome in psychogenic water drinkers with severe symptomatic hyponatremia: The effect of rapid correctionHyperthermia, hypertension, hypertonia, and coma in a massive thioridazine overdoseSIADH: A Serious Side Effect of Psychotropic DrugsReactions to AntipsychoticsSerum electrolyte abnormalities caused by drugsTreatment of Hypoosmolar and Hyperosmolar StatesEffect of Neuroleptics on Pituitary Function in ManFluid—Electrolyte, Acid—Base Disorders 1 July 1978Volume 89, Issue 1Page: 147-148KeywordsAntidiuretic hormoneAttentionBlood urea nitrogenSodiumSyndrome of inappropriate antidiuretic hormone secretionUrine Issue Published: 1 July 1978 PDF DownloadLoading ...