tbuckley/cabot-search huggingface dataset:
Back pain--what can we offer?
Authors: R W Porter
Journal: BMJ (1979)

apparent fall in LAA concentration was simply due to the increasing proportion of granulo- cytes in the differential white blood cell count, and that a true fall in LAA concentration had not occurred.After the acute "stress" had subsided and the leucocytosis returned to normal, however, the LAA concentration and serum ascorbic acid concentration remained low, presumably because of tissue depletion of ascorbic acid.Both may remain low for up to 56 days.2We also found that tissue damage is pro- bably necessary to produce the long-term depletion of LAA and serum ascorbic acid concentrations since the acute changes in LAA only can be produced by tetracosactrin infusions in normal subjects.2
Personality traits, national character stereotypes, and climate–economic conditions
Authors: Antonio Terracciano, Wayne Chan
Journal: Behavioral and Brain Sciences (2013)

Abstract Cross-cultural personality research suggests that individuals from wealthier countries tend to be more open-minded. This openness to values may support more democratic governments and the expansion of fundamental freedoms. The link between wealth and freedom is evident in cold-to-temperate climates, but not across wealthy nations in hot climates. Furthermore, temperature and economic conditions shape perceptions of national character stereotypes.
Staphylococcal Scarlet Fever
Authors: Clayton A. Feldman
Journal: New England Journal of Medicine (1962)

THE unusual clinical entity of staphylococcal scarlet fever was described by Aranow and Wood1 in 1942, in a patient with staphylococcal osteomyelitis and bacteremia, in whom the typical rash and desquamation of scarlet fever developed; a soluble filtrate of the offending organism produced an erythrogenic toxin, which, on injection in Dick-positive volunteers, caused a positive reaction. A negative reaction was found in patients convalescing from staphylococcal scarlatina. The positive reaction could be prevented by the prior admixture of the toxin with scarlatina (streptococcal) antitoxin. Stevens2 had described 3 patients with scarlet fever in conjunction with staphylococcal infection in 1927, all . . .
Cross sectional study of conventional cervical smear, monolayer cytology, and human papillomavirus DNA testing for cervical cancer screening
Authors: Joël Coste, Béatrix Cochand-Priollet, Patricia de Cremoux, Catherine Le Galès, Isabelle Cartier, Vincent Molinié, Sylvain Labbé, Marie-Cécile Vacher-Lavenu, Philippe Vielh
Journal: BMJ (2003)

To compare the sensitivity, specificity, and interobserver reliability of conventional cervical smear tests, monolayer cytology, and human papillomavirus testing for screening for cervical cancer.Cross sectional study in which the three techniques were performed simultaneously with a reference standard (colposcopy and histology).Public university and private practices in France, with complete independence from the suppliers.828 women referred for colposcopy because of previously detected cytological abnormalities and 1757 women attending for routine smears.Clinical readings and optimised interpretation (two blind readings followed, if necessary, by consensus). Sensitivity, specificity, and weighted kappa computed for various thresholds of abnormalities.Conventional cervical smear tests were more often satisfactory (91% v 87%) according to the Bethesda system, more reliable (weighted kappa 0.70 v 0.57), and had consistently better sensitivity and specificity than monolayer cytology. These findings applied to clinical readings and optimised interpretations, low and high grade lesions, and populations with low and high incidence of abnormalities. Human papillomavirus testing associated with monolayer cytology, whether systematic or for atypical cells of undetermined significance, performed no better than conventional smear tests.Monolayer cytology is less reliable and more likely to give false positive and false negative results than conventional cervical smear tests for screening for cervical cancer.
UK's smaller parties parade their health policies
Authors: N. Hawkes
Journal: BMJ (2010)

Aim was to study the relationship of the pulmonary arterial pressure [PAP] rise at high altitude [HA] with cardiopulmonary exercise test [CPET] and saturation during short-term acclimatization. Material and methods. 52 men aged 18 to 35 years were examined. The baseline CPET, pulse oximetry and echocardiography were performed (760 m). On the 2nd day (3200 m) pulse oximetry and echocardiography were repeated, whereas CPET, was appointed only on the 7<sup>th</sup> and 14<sup>th</sup> days at HA. Results. There were significant both rise of systolic PAP (23,2±1,6 vs 29,8±4,3 mmHg; p&lt; 0,001) and decrease of saturation (97,2±0,9 vs 92,4±1,8%; p&lt; 0,001) after the HA ascent. The table 1 shows results of CPET. There were significant decrease of parameters, related with oxygen consumption. Meanwhile the maximal minute ventilation [MMV] was significantly increased. Systolic PAP correlated inversely with saturation (r= -0,52; p&lt; 0,001) at 2<sup>nd</sup> HA day and directly MMV (r= 0,46; p&lt; 0,01) at 7<sup>th</sup> HA day. No correlation was found with the rest CPET parameters. Conclusion. Because of moderate correlation of systolic PAP at HA with oxygen saturation and MMV it could be suggested that successful adaptation is related with MMV and saturation. To obtain more conclusive data it is necessary to carry out CPET earlier or at the higher altitude.
Noninvasive single-beat determination of left ventricular end-systolic elastance in humans
Authors: Chen-Huan Chen, Barry Fetics, Erez Nevo, Carlos E. Rochitte, Kuan-Rau Chiou, PhillipYu-An Ding, Miho Kawaguchi, David A. Kass
Journal: Journal of the American College of Cardiology (2001)
Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes
Authors: Rebecca A. Marsh, Kanchan Rao, Prakash Satwani, Kai Lehmberg, Ingo Müller, Dandan Li, Mi-Ok Kim, Alain Fischer, Sylvain Latour, Petr Sedlacek, Vincent Barlogis, Kazuko Hamamoto, Hirokazu Kanegane, Sam Milanovich, David A. Margolis, David Dimmock, James Casper, Dorothea N. Douglas, Persis J. Amrolia, Paul Veys, Ashish R. Kumar, Michael B. Jordan, Jack J. Bleesing, Alexandra H. Filipovich
Journal: Blood (2012)
Fertility and Markers of Male Reproductive Function in Inuit and European Populations Spanning Large Contrasts in Blood Levels of Persistent Organochlorines
Authors: Jens Peter Bonde, Gunnar Toft, Lars Rylander, Anna Rignell-Hydbom, Aleksander Giwercman, Marcello Spano, Gian Carlo Manicardi, Davide Bizzaro, Jan K. Ludwicki, Valentina Zvyezday, Eva C. Bonefeld-Jørgensen, Henning Sloth Pedersen, Bo A.G. Jönsson, Ane Marie Thulstrup
Journal: Environmental Health Perspectives (2007)

We synthesized the main findings from an international epidemiologic study on the impact of biopersistent organic pollutants (POPs) on human reproductive function.We used a database with interview and biological data from 2,269 women and their spouses, and 18 published core papers.The study did not provide direct evidence of hormone-like activity of the polychlorinated biphenyl (PCB) congener CB-153 and the main dichlorodiphenyltrichloroethane (DDT) metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE), as serum concentrations of these compounds were not consistently related to either endogenous or exogenous hormone activity in serum. Nevertheless several links bewteen POP exposure and biomarkers of male reproductive function were identified. First, an association between high CB-153 serum levels and low sperm counts was detected within a subgroup of men with short androgen receptor CAG repeat length. Second, a relationship between increased CB-153 serum concentrations and decreased sperm motility was seen in all four studied regions, and indications of reduced neutral alpha-glucosidase activity in seminal plasma point to a post-testicular effect. Third, damage of sperm chromatin integrity was considerably less frequent in Greenlandic Inuits compared with that in European groups, and only in the latter was impairment of sperm chromatin integrity related to POPs. Despite these effects, fertility in terms of time taken to conceive was not related to POPs except in Inuits. A likely explanation of the latter was not identified.POPs may interfere with male reproductive function without major impact on fertility. The data do not provide direct evidence for endocrine disruption, hence other mechanisms should also be considered.
lodoamphetamine-123 Brain Imaging Demonstrating Cortical Deactivation in a Patient with Progressive Supranuclear Palsy
Authors: JAMES H. TIMMONS, FRNAK W. BONIKOWSKI, MICHAEL F. HARTSHORNE
Journal: Clinical Nuclear Medicine (1989)

Dementia associated with cerebral atrophy may result from progressive supranuclear palsy (PSNP), a subcortical disease marked by dysfunction of the prefrontal lobe. The cerebral cortex is usually normal. Although the CT appearance is that of nonspecific atrophy, the appearance on functional brain images is distinctive. Decreased cortical activity with an intact cortical rim and decreased basal ganglia activity are identified in a patient with PSNP on a functional brain image obtained with iodoamphetamine-123. These findings distinguish PSNP from other dementing diseases with similar clinical findings, such as senile dementia of the Alzheimer's type and Pick's disease.
The Value of Our Care
Authors: Emmy M. Graber, Lawton Robert Burns
Journal: JAMA Dermatology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
LYMPHOCYTE TRANSFORMATION, LEUCOCYTE MIGRATION, SPECIFIC IgE, IgG AND IgM BEFORE, DURING, AND AFTER PENICILLIN TREATMENT WITHOUT ADVERSE REACTION <i>A Follow‐Up Study</i>
Authors: J. H. SAURAT, C. PONVERT, C. BURTIN, C. SOUBRANE, B. LEBEL, F. BEUCHER, J. PAUPE
Journal: Allergy (1976)

This in vitro follow-up study of the penicillin-induced immune response by a well-tolerated regimen was conducted with an association of four tests: lymphocyte transformation test; leucocyte migration test; passive anaphylaxis on monkey lung tissue; and passive hemagglutination. It showed (1) that previously sensitized subjects (including IgE) tolerated the treatment by pencillin. (2) That the treatment induced either a transient positive conversion of previously negative tests or a negative conversion of previously positive tests. These in vitro findings are in accordance with previously established concepts based upon cutaneous tests and must be taken into consideration when interpretating in vitro diagnosis of penicillin allergy.
Castor-Oil in Neuralgia.
Authors: A. W. Knotts
Journal: JAMA (1900)

Ogden, Ind., Aug. 25, 1900. <h3>To the Editor:</h3> —I read with much interest Dr. Moyer's article on castor-oil in neuralgia, and also the article by Dr. Caldwell on the same subject. I have a patient under my care who has suffered for years with supraorbital neuralgia. She has been under the care of various physicians, who have prescribed cod-liver oil and other restoratives, and probably the entire list of anodynes and analgesics. The patient having a history of chronic constipation I began the use of Dorsey's solution, but the attacks returned with their usual severity and regularity. About two months ago I began the use of the following: I have given the above every day since beginning the treat-ment. The patient has had but one attack since, and that a very mild one. Her general appearance is much improved, and her chronic constipation is a thing of the past.
Medicine's Role Evolves in Haiti Restoration
Authors: Phil Gunby
Journal: JAMA (1994)

PHYSICIANS HAVE been involved in Operation Uphold Democracy—the effort to restore President Jean-Bertrand Aristide to office—from the planning stage into this 12th week of US military presence in Haiti. James B. Peake, MD, who was involved in planning the operation and who flew into Port-au-Prince with the first US forces September 19, has returned to the United States, been promoted to the two-star grade of major general, and has taken command of Madigan Army Medical Center, Tacoma, Wash. US Army physicians in command in Haiti now are V. Thomas Deal, Jr, MD, commanding the 28th Combat Support Hospital in Port-au-Prince in the south on the Bay of Gonave not far from the Caribbean Sea, and Larry J. Godfrey, MD, working as the joint task force surgeon, with medical assets in Port-au-Prince as well as Cap Haitien on the north (Atlantic Ocean) coast, and with the 10th Mountain Division. Deal is
The Antihypertensive Effects of Chlorthalidone
Authors: J. MARION BRYANT, NATALIO SCHVARTZ, SETA TOROSDAG, LUCIAN FLETCHER, HARRISON FERTIG, M. STEPHEN SCHWARTZ, RICHARD B. F. QUAN, JOHN J. MCDERMOTT, THOMAS B. SPENCER
Journal: Circulation (1962)

Chlorthalidone administered in a single daily dose (200 mg. per day) produced a significantly greater hypotensive effect than chlorothiazide (250 mg. t.i.d.) and a greater, but not significantly different, response than hydrochlorothiazide (25 mg. t.i.d.). Reserpine (0.1 to 0.5 mg. per day) significantly augmented the hypotensive effect of chlorthalidone, but chlorthalidone given alone produced an effect equal to the combination of a benzothiazide with reserpine. Side effects characteristic of sulfonamide diuretics of minimal degree, including hyperuricemia, accompany chlorthalidone administration. Presently, chlorthalidone, when individualization of dosage is observed, approaches an ideal sulfonamyl for the control of hypertension in relation to that of other members of this chemical series.
NICE recommends women should choose where to give birth
Authors: Susan Mayor
Journal: BMJ (2007)

UK NEWS UK Biobank gets 10% response rate as it starts recruiting volunteers, p659 World NEWS US �u�ge bans use o�� ter�� �lig�t cigarette�� �orl��i�e, p65� US �u�ge bans use o�� ter�� �lig�t cigarette�� �orl��i�e
Trigeminal Neuralgia and Dental Malocclusions
Authors: G. A. S. Blair, D. S. Gordon
Journal: BMJ (1973)

Out of 39 patients with intractable trigeminal neuralgia seven have had continuing relief for over three years after dental treatment. Five out of six recent consecutive edentulous patients had immediate improvement. More radical treatment, such as ganglion injection or nerve root section, has been at least postponed.
Problems That Merit Investigation in Clinical Microbiology Laboratories
Authors: JOHN M. MATSEN
Journal: Annals of Internal Medicine (1978)

Research is needed in the following areas in clinical microbiology: specimen collection, microbial identification, automation and instrumentation, rapid microbial diagnoses, microbial metabolism, computerization, relevance and laboratory utilization, physician influence, training in clinical microbiology, media and reagents, quality control, and antimicrobial susceptibility and assay determinations. For optimal progress in many of these categories, federal funding should be made available.
Assessment of Patient-Led or Physician-Driven Continuous Glucose Monitoring in Patients With Poorly Controlled Type 1 Diabetes Using Basal-Bolus Insulin Regimens
Authors: Jean-Pierre Riveline, Pauline Schaepelynck, Lucy Chaillous, Eric Renard, Agnès Sola-Gazagnes, Alfred Penfornis, Nadia Tubiana-Rufi, Véronique Sulmont, Bogdan Catargi, Céline Lukas, Régis P. Radermecker, Charles Thivolet, François Moreau, Pierre-Yves Benhamou, Bruno Guerci, Anne-Marie Leguerrier, Luc Millot, Claude Sachon, Guillaume Charpentier, Hélène Hanaire
Journal: Diabetes Care (2012)

The benefits of real-time continuous glucose monitoring (CGM) have been demonstrated in patients with type 1 diabetes. Our aim was to compare the effect of two modes of use of CGM, patient led or physician driven, for 1 year in subjects with poorly controlled type 1 diabetes.
Prevention of Excess Hemolysis During Cardiopulmonary Bypass by the Use of Mannitol
Authors: GEORGE A. PORTER, DONALD W. SUTHERLAND, COLIN W. MCCORD, ALBERT STARR, HERBERT E. GRISWOLD, JEAN KIMSEY
Journal: Circulation (1963)

Mannitol infusion has significantly decreased plasma hemoglobin build-up rate in mitral and aortic valvular replacement. This occurred before hemoglobin appeared in the urine, and was unrelated to the binding of hemoglobin by haptoglobin. The mechanism by which mannitol decreases the build-up rate of plasma hemoglobin is unknown, but seems to be other than by renal excretion of hemoglobin.
Industrial Accidents and New Legislation
Authors: D. Stewart
Journal: BMJ (1946)

This new legislation is a significant social measure.Its pro- visions fundamentally change the present system of workmen's compensation, which has frequently tended to retard recovery and interfere with treatment and rehabilitation.Properly administered, and with due regard to the need for the Minister of National Insurance maintaining it as a social service dealing with persons and personalities, the scheme should pro've a great improvement over the Workmen's Compensation Acts, which it replaces; it should remove much of the friction which present conditions can stimulate between employee and employer, and should promote a feeling of greater security on the part of the injured worker and thus assist rehabilitation and accelerate his return to work.But new legislation which can materially influence the work of the medical profession-and in which.,themedical
MEDICAL TREATMENT OF PEPTIC ULCER WITHOUT ALKALIS
Authors: ANDERS FRICK
Journal: JAMA (1924)

The large majority of cases of peptic ulcer which are capable of developing granulations and which are free from serious complications, such as profuse and repeated hemorrhages, perforation, perigastritis and periduodenitis with abscess, phlegmonous gastritis, hour-glass stomach, perhaps burrowing and deep penetration as revealed on the roentgenogram, organic pyloric obstruction and duodenal diverticulum, will heal readily under medical treatment no matter whether they are gastric, pyloric or duodenal. This holds true even in cases in which there is a moderate degree of retention of the gastric contents or a digestive or intermittently continuous hypersecretion with or without spastic or inflammatory pyloric obstruction.  In deciding on a medical treatment of peptic ulcer, one should take into consideration not so much the causation of the ulcer as the factors that prevent its healing. No matter what fundamental cause brought on the ulcer, it is a thing of the past and cannot be
VALIDATION AND QUANTIFICATION OF GENETIC DETERMINATION OF LIPOPROTEIN (LP)(A) LEVELS AND PREDICTIVE VALUE FOR ANGIOGRAPHIC CORONARY ARTERY DISEASE (CAD)
Authors: Jeffrey L. Anderson, Stacey Knight, Benjamin Horne, Tami Bair, John Huntinghouse, Jeffrey Rollo, Heidi May, J. Muhlestein, john carlquist
Journal: Journal of the American College of Cardiology (2012)
High Frequency of Type 1B (Idiopathic) Diabetes in North Indian Children With Recent-Onset Diabetes
Authors: Krishnamurthy Balasubramanian, Preeti Dabadghao, Vijayalakshmi Bhatia, Peter G. Colman, Shane A. Gellert, Udalak Bharadwaj, Suraksha Agrawal, Nalini Shah, Eesh Bhatia
Journal: Diabetes Care (2003)

Islet antibody–negative or type 1B (idiopathic) diabetes constitutes 5–10% of Caucasian diabetic subjects with recent-onset type 1 diabetes (1). A study from Italy (2) failed to show clinical differences between these patients and those with antibodies. In contrast, a fulminant form of type 1B diabetes with associated exocrine pancreatic involvement, possibly secondary to viral infection, has been described in Japanese (3). There is little information on type 1B diabetes in other racial groups. Therefore, we studied the frequency and characteristics of type 1B diabetes in children of north Indian origin.

We studied all 55 children (32 male and 23 female) with recent-onset type 1 diabetes who presented at our diabetes clinic over a 10-year period. Subjects had …
Lasso Technique for Retrieval of a Dislocated and Impacted Esophageal Stent
Authors: U. Weickert, R. Jakobs, E. Siegel, D. Schilling, J. F. Riemann
Journal: Endoscopy (2004)

With the advent of self-expanding metal stents, esophageal stent insertion has become a relatively simple method of relieving dysphagia due to esophageal cancer. However, stent migration is a well-recognized complication. If dislocation occurs, endoscopic retrieval using a forceps and/or polypectomy snare is usually possible [1]. To use these techniques, at least one end of the stent has to be accessible to the snare.
Perioperative Outcomes Following Surgical Resection of Renal Cell Carcinoma with Inferior Vena Cava Thrombus Extending Above the Hepatic Veins: A Contemporary Multicenter Experience
Authors: E. Jason Abel, R. Houston Thompson, Vitaly Margulis, Jennifer E. Heckman, Megan M. Merril, Oussama M. Darwish, Laura-Maria Krabbe, Stephen A. Boorjian, Bradley C. Leibovich, Christopher G. Wood
Journal: European Urology (2013)
Reproduction, Embryonic Development, and Maternal Transfer of Contaminants in the Amphibian <i>Gastrophryne carolinensis</i>
Authors: William Alexander Hopkins, Sarah Elizabeth DuRant, Brandon Patrick Staub, Christopher Lee Rowe, Brian Phillip Jackson
Journal: Environmental Health Perspectives (2005)

Although many amphibian populations around the world are declining at alarming rates, the cause of most declines remains unknown. Environmental contamination is one of several factors implicated in declines and may have particularly important effects on sensitive developmental stages. Despite the severe effects of maternal transfer of contaminants on early development in other vertebrate lineages, no studies have examined the effects of maternal transfer of contaminants on reproduction or development in amphibians. We examined maternal transfer of contaminants in eastern narrow-mouth toads (Gastrophryne carolinensis) collected from a reference site and near a coal-burning power plant. Adult toads inhabiting the industrial area transferred significant quantities of selenium and strontium to their eggs, but Se concentrations were most notable (up to 100 microg/g dry mass). Compared with the reference site, hatching success was reduced by 11% in clutches from the contaminated site. In surviving larvae, the frequency of developmental abnormalities and abnormal swimming was 55-58% higher in the contaminated site relative to the reference site. Craniofacial abnormalities were nearly an order of magnitude more prevalent in hatchlings from the contaminated site. When all developmental criteria were considered collectively, offspring from the contaminated site experienced 19% lower viability. Although there was no statistical relationship between the concentration of Se or Sr transferred to eggs and any measure of offspring viability, our study demonstrates that maternal transfer may be an important route of contaminant exposure in amphibians that has been overlooked.