Enalapril for Pregnancy-Induced Hypertension: Acute Renal Failure in a Neonate
Authors: GREGOR SCHUBIGER
Journal: Annals of Internal Medicine (1988)

Brief Reports1 February 1988Enalapril for Pregnancy-Induced Hypertension: Acute Renal Failure in a NeonateGREGOR SCHUBIGER, M.D., GEORGES FLURY, M.D., JUERG NUSSBERGER, M.D.GREGOR SCHUBIGER, M.D., GEORGES FLURY, M.D., JUERG NUSSBERGER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-2-215 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFatal neonatal anuria has been described after administration of the angiotensin converting enzyme inhibitor Captopril during pregnancy (1, 2). Animal experiments (3) and observations in patients with renal artery stenosis (4) show the importance of the renin-angiotensin system in regulating glomerular filtration rate when renal perfusion pressure is low. In newborns, arterial pressure is low, and renal autoregulation might be warranted by the highly activated renin-angiotensin system (5). We report a case of reversible acute renal failure in a premature newborn (35 weeks) whose mother had received the angiotensin converting enzyme inhibitor enalapril, 20 mg/d for 17 days, before delivering...References1. GUIGNARD J, BURGENER F, and CALAME A. Persistent anuria in a neonate: a side effect of Captopril? [Abstract]. Int J Pediatr Nephrol. 1981;2:133. Google Scholar2. ROTHBERG A and LORENZ R. Can Captopril cause fetal and neonatal renal failure? Pediatr Pharmacol. 1984;4:189-92. MedlineGoogle Scholar3. HALL J, GUYTON A, JACKSON T, COLEMAN T, LOHMEIER T, and TRIPPODO N. Control of glomerular filtration rate by renin-angiotensin system. Am J Physiol. 1977;233:F366-72. MedlineGoogle Scholar4. HRICIK D, BROWNING P, KOPELMAN R, GOORNO W, MADIAS N, and DZAU V. Captopril-induced functional renal insufficiency in patients with bilateral renal-artery stenoses or renal-artery stenosis in a solitary kidney. N Engl J Med. 1983;308:373-6. CrossrefMedlineGoogle Scholar5. 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True versus immunoreactive angiotensin II in human plasma. Hypertension. 1985;7(suppl I):I1-7. MedlineGoogle Scholar10. MAURY M, WALTI H, RICHER C, FRANCOUAL C, RELIER J, and GIUDICELLI J. Serum angiotensin I-converting enzyme activity in premature and full-term infants. Biol Neonate. 1984;45:102-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GREGOR SCHUBIGER, M.D.; GEORGES FLURY, M.D.; JUERG NUSSBERGER, M.D.Affiliations: University Hospital Lausanne Switzerland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCase of iatrogenic neonatal acute kidney injury requiring dialysis and review of literatureDilated Cardiomyopathy and PregnancyPeripartum cardiomyopathy-diagnosis, management, and long term implicationsGlomerular Diseases in PregnancyComplications of PreeclampsiaObstetrics: The Hospitalist's Approach to the Pregnant PatientAngiotensin converting enzyme inhibitors induced acute kidney injury in newbornGlomerular Diseases in PregnancySafety of Enalapril in Infants Admitted to the Neonatal Intensive Care UnitA complicated role for the renin–angiotensin system during pregnancy: highlighting the importance of drug discoveryIs there an embryopathy associated with first-trimester exposure to angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists? 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LINDHEIMER, M.D., WILLIAM M. BARRON, M.D.Correction: Enalapril for Pregnancy-Induced Hypertension: Acute Renal Failure in a Neonate 1 February 1988Volume 108, Issue 2Page: 215-216KeywordsAcute renal failureAngiotensin converting enzyme inhibitorBlood pressureGlomerular filtration rateHypertensionInfantsPregnancyRenal arteriesStenosis ePublished: 1 December 2008 Issue Published: 1 February 1988 PDF downloadLoading ...