tbuckley/cabot-search huggingface dataset:
The potential role of pre‐transplant HBcIgG seroposivity as predictor of clinically relevant cytomegalovirus infection in patients with lymphoma undergoing autologous hematopoietic stem cell transplantation: A study from the Rome Transplant Network
Authors: Francesco Marchesi, Federica Giannotti, Giuseppe Avvisati, Maria Concetta Petti, Fulvia Pimpinelli, Pierpaolo Paba, Maria Laura Dessanti, Raffaella Cerretti, Maria Cristina Tirindelli, Alessandra Picardi, Mariella D'Andrea, Antonio Spadea, Fabrizio Ensoli, Carlo Federico Perno, Andrea Mengarelli, William Arcese
Journal: American Journal of Hematology (2011)

Despite the increased use of intensive immunosuppressive chemo-immunotherapies in patients with lymphoma observed in the last decade, current data on cytomegalovirus (CMV) infection following autologous stem cell transplantation (Auto-SCT) are very limited. To address this peculiar aspect, a retrospective study on a cohort of 128 adult patients consecutively transplanted for lymphoma in three Hematology Institutions was performed with the aim to determine the incidence of and the risk factors for CMV symptomatic infection and/or end-organ disease. Sixteen patients (12.5%) required specific antiviral therapy and 4/16 died (25%); transplant-related mortality (TRM) was significantly influenced by CMV infection (P = 0.005). In univariate analysis, a pre-transplant HBcIgG seropositivity, HBV infection according to clinical-virological definitions, a pre-transplant Rituximab treatment, a diagnosis of B-cell non-Hodgkin lymphoma, and age at transplant were significantly associated with the risk of developing a clinically relevant CMV infection. In multivariate analysis, only a pre-transplant HBcIgG seropositivity (P = 0.008) proved to be an independent predictor of a clinically relevant CMV infection. These results suggest that a pre-transplant HBcIgG seropositivity could be considered as an independent predictor factor of clinically relevant CMV infection after Auto-SCT.
A Latex Nucleoprotein Test for Diagnosis of Systemic Lupus Erythematosus
Authors: Edmund L. Dubois
Journal: JAMA (1961)

THE aim of this brief report is to review our experience with a simplified commercially available latex nucleoprotein agglutination test for the diagnosis of systemic lupus erythematosus (SLE) and to correlate it with a sensitive cytological method for detection of LE cells. These studies were performed on a group of 320 cases with various forms of lupus erythematosus, allied disorders, unrelated conditions, and normal controls.  Since Hargraves' classic description of the LE phenomenon in 1948, the incidence of SLE has greatly increased, most likely as a result of our ability to confirm diagnoses in otherwise equivocal cases by demonstration of LE cells.1Studies by Miescher and others have shown that the LE inclusion body is probably an antinuclear autoantibody reaction.2,3It was hoped that the sensitivity of the antinuclear antibody tests might be greater and more specific than the cytological methods.  Numerous modifications of these reactions have
THE TREATMENT OF PLANTAR WARTS BY FORMALIN
Authors: SYDNEY THOMSON
Journal: British Journal of Dermatology (1943)

Journal Article THE TREATMENT OF PLANTAR WARTS BY FORMALIN Get access SYDNEY THOMSON SYDNEY THOMSON Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 55, Issue 11, 1 November 1943, Pages 267–269, https://doi.org/10.1111/j.1365-2133.1943.tb10718.x Published: 01 November 1943
1190 SILEN-C2: EARLY ANTIVIRAL ACTIVITY AND SAFETY OF BI 201335 COMBINED WITH PEGINTERFERON ALFA-2A AND RIBAVIRIN (PEGIFN/RBV) IN CHRONIC HCV GENOTYPE-1 PATIENTS WITH NON-RESPONSE TO PEGIFN/RBV
Authors: M. Sulkowski, M. Bourliere, J.-P. Bronowicki, A. Streinu-Cercel, L. Preotescu, T. Asselah, J.-M. Pawlotsky, S. Shafran, S. Pol, F.A. Caruntu, S. Mauss, D. Larrey, C. Häfner, Y. Datsenko, J. Stern, R. Kubiak, G. Steinmann
Journal: Journal of Hepatology (2010)
Future Roles of Subspecialists
Authors: Stephen J. Seligman
Journal: Annals of Internal Medicine (1996)

Letters15 September 1996Future Roles of SubspecialistsStephen J. Seligman, MDStephen J. Seligman, MDState University of New York Health Science Center, Brooklyn, NY 11203Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-6-199609150-00042 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Langdon and colleagues [1] have assessed the future roles and training of internal medicine subspecialists. Of particular interest to those of us in academic medicine who are interested in basic laboratory investigations is that the authors advocate the formation of a category of “subspecialist investigator” with a subdivision into “basic scientist” and “clinical investigator.” I hope that their ideas will stimulate support for the nurturing of physicians in research.The authors also propose periods of training and a suggested curriculum; these are a source of concern. Persons who are effective in research have skills that differ from ...REFERENCE1. Langdon LO, Toskes PP, Kimball HR, the American Board of Internal Medicine Task Force on Subspecialty Internal Medicine. Future roles and training of internal medicine subspecialists. Ann Intern Med. 1996; 124:686-91. Google Scholar Author, Article, and Disclosure InformationAffiliations: State University of New York Health Science Center, Brooklyn, NY 11203 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1996Volume 125, Issue 6Page: 524KeywordsAcademic medicineFallsForecastingPatientsResearch laboratoriesScientistsSub-specialty care Issue Published: 15 September 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
microRNAs, an active and versatile group in cancers
Authors: Jeffrey Liu, Min Zheng, Yaling Tang, Xinhua Liang, Qin Yang
Journal: International Journal of Oral Science (2011)

microRNAs (miRNAs) are a class of non‐coding RNAs that function as endogenous triggers of the RNA interference pathway. Studies have shown that thousands of human protein‐coding genes are regulated by miRNAs, indicating that miRNAs are master regulators of many important biological processes, such as cancer development. miRNAs frequently have deregulated expression in many types of human cancers, and play critical roles in tumorigenesis, which functions either as tumor suppressors or as oncogenes. Recent studies have shown that miRNAs are highly related with cancer progression, including initiating, growth, apoptosis, invasion, and metastasis. Furthermore, miRNAs are shown to be responsible for the cancer‐related inflammation, anti‐cancer drug resistance, and regulation of cancer stem cells. Therefore, miRNAs have generated great interest as a novel strategy in cancer diagnosis and therapy. Here we review the versatile roles of miRNAs in cancers and their potential applications for diagnosis, prognosis, and treatment as biomarkers.
Renin Angiotensin Activity in 100 Hypertensive Patients.
Authors: Harold D. Itskovitz
Journal: Annals of Internal Medicine (1967)

s1 May 1967Renin Angiotensin Activity in 100 Hypertensive Patients.Harold D. Itskovitz, M.D., Eugene A. Hildreth, M.D., F.A.C.P.Harold D. Itskovitz, M.D.Search for more papers by this author, Eugene A. Hildreth, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1037_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPlasma renin measurements or histologic evaluations of renal juxtaglomerular (JG) cells were performed in 100 hypertensive patients. Twenty-four of these patients were found to have evidence of increased renin angiotensin activity. Headaches, heart failure, higher blood pressures, advanced hypertensive retinopathy, and azotemia occurred with greater frequency in this group than among those with lower renin values. Nocturia was the most common symptom (77%) of patients with elevated renin activity. Laboratory abnormalities occurring with high frequency in this group included hypokalemia (K + < 3.5 mEq/liter), 79%; hyponatremia (N + < 134 mEq/liter), 21%; and proteinuria (⩾ 1 +), 75%. Sixty-two... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1967Volume 66, Issue 5Page: 1037-1038KeywordsBlood plasmaBlood pressureCellsHeart failureHyponatremiaProteinuriaResearch laboratoriesRetinopathy Issue Published: 1 May 1967 PDF downloadLoading ...
Obstetric Evidence Based GuidelinesWomen's Health and Disease: Gynecologic, Endocrine, and Reproductive Issues
Authors: Ronald T. Burkman
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risk Factors for Drug-Resistant Pathogens in Community-acquired and Healthcare-associated Pneumonia
Authors: Yuichiro Shindo, Ryota Ito, Daisuke Kobayashi, Masahiko Ando, Motoshi Ichikawa, Akira Shiraki, Yasuhiro Goto, Yasutaka Fukui, Mai Iwaki, Junya Okumura, Ikuo Yamaguchi, Tetsuya Yagi, Yoshimasa Tanikawa, Yasuteru Sugino, Joe Shindoh, Tomohiko Ogasawara, Fumio Nomura, Hideo Saka, Masashi Yamamoto, Hiroyuki Taniguchi, Ryujiro Suzuki, Hiroshi Saito, Takashi Kawamura, Yoshinori Hasegawa
Journal: American Journal of Respiratory and Critical Care Medicine (2013)

Rationale: Identification of patients with drug-resistant pathogens at initial diagnosis is essential for treatment of pneumonia.Objectives: To elucidate clinical features of community-acquired pneumonia (CAP) and healthcare-associated pneumonia (HCAP), and to clarify risk factors for drug-resistant pathogens in patients with CAP and HCAP.Methods: A prospective observational study was conducted in hospitalized patients with pneumonia at 10 institutions in Japan. Pathogens identified as not susceptible to ceftriaxone, ampicillin-sulbactam, macrolides, and respiratory fluoroquinolones were defined as CAP drug-resistant pathogens (CAP-DRPs).Measurements and Main Results: In total, 1,413 patients (887 CAP and 526 HCAP) were analyzed. CAP-DRPs were more frequently found in patients with HCAP (26.6%) than in patients with CAP (8.6%). Independent risk factors for CAP-DRPs were almost identical in patients with CAP and HCAP. These included prior hospitalization (adjusted odds ratio [AOR], 2.06; 95% confidence interval [CI], 1.23–3.43), immunosuppression (AOR, 2.31; 95% CI, 1.05–5.11), previous antibiotic use (AOR, 2.45; 95% CI, 1.51–3.98), use of gastric acid–suppressive agents (AOR, 2.22; 95% CI, 1.39–3.57), tube feeding (AOR, 2.43; 95% CI, 1.18–5.00), and nonambulatory status (AOR, 2.45; 95% CI, 1.40–4.30) in the combined patients with CAP and HCAP. The area under the receiver operating characteristic curve for counting the number of risk factors was 0.79 (95% CI, 0.74–0.84).Conclusions: The clinical profile of HCAP was different from that of CAP. However, physicians can predict drug resistance in patients with either CAP or HCAP by taking account of the cumulative number of the risk factors.Clinical trial registered with https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&type=summary&recptno=R000004001&language=E; number UMIN000003306.
The First Reusable Multiple-Band Ligator for Endoscopic Hemostasis of Variceal Bleeding, Nonvariceal Bleeding and Mucosal Resection
Authors: None Ell, None May, None Wurster
Journal: Endoscopy (1999)

A new multiband ligator is presented which is fully reusable. Experience in 67 patients (22 with varices and 45 with early cancers undergoing mucosal resection) showed good technical function and no significant complications. Use of this device may significantly reduce the costs of endoscopic ligation.
Follow up study of longstanding depression as predictor of mortality in elderly people living in the community
Authors: T. Pulska, K. Pahkala, P. Laippala, S.-L. Kivela
Journal: BMJ (1999)

Longstanding and recurrent depressive disorders are quite common in elderly people. 1 2 Not much is known, however, of their clinical course and prognosis, including mortality.The need for treatment of longstanding, less severe depressive disorders is a matter of discussion.We studied the relation between longstanding or recurrent depressive disorders and mortality and that between recovery from depressive disorders and mortality in elderly people. Subjects, methods, and resultsThis study is based on the Ähtäri longitudinal epidemiological research project concerning depression in elderly people. [1]2][3] The initial series consisted of people born in 1923 or earlier and living in the municipality of Ähtäri, Finland, on 1 January 1984 (n = 1529).In the first study in 1984-5 the participation rate was 91%.The follow up study was performed in 1989-90 with a participation rate of 94%.Depression was determined after semistructured interviews by the criteria of the Diagnostic and Statistical Manual of Mental Disorders, third edition (DSM-III). [1]][3] We examined mortality in subjects with a longstanding or recurrent course of depression and those who had recovered.Three groups were formed from those people without dementia who were alive in both 1984-5 and 1989-90: people depressed in both assessments (n = 78), people depressed in 1984-5 but not depressed in 1989-90 (n = 101), and people not depressed in both assessments (n = 634).The mean (SD) age of those participating in the follow up study was 74.3 (6.1) years on 1 January 1989.The mortality data from the official statistics were collected for a period from the individual examination days in 1989-90 to 31 December 1995.The causes of death did not differ between the groups, cardiovascular and cerebrovascular diseases and malignant neoplasms being the most common.According to Kaplan-Meier survival analysis, 48% of the people with depression at both time points had died compared with 26% in the group without depression at both times (P < 0.001).In the group with
Evidence on measures for the prevention of ventilator-associated pneumonia
Authors: L. Lorente, S. Blot, J. Rello
Journal: European Respiratory Journal (2007)

Ventilator-associated pneumonia (VAP) continues to be an important cause of morbidity and mortality in ventilated patients. Evidence-based guidelines have been issued since 2001 by the European Task Force on ventilator-associated pneumonia, the Centers for Disease Control and Prevention, the Canadian Critical Care Society, and also by the American Thoracic Society and Infectious Diseases Society of America, which have produced a joint set of recommendations. The present review article is based on a comparison of these guidelines, together with an update of further publications in the literature. The 100,000 Lives campaign, endorsed by leading US agencies and societies, states that all ventilated patients should receive a ventilator bundle to reduce the incidence of VAP. The present review article is useful for identifying evidence-based processes that can be modified to improve patients' safety.
Mother accused of murder after refusing caesarean section
Authors: Charles Marwick
Journal: BMJ (2004)

A woman in Salt Lake City, Utah, has been charged with murder after the death of one of her near term twins—the result, say prosecutors, of her refusal to have a medically advised caesarean section. The infants, one female and the other male, were delivered on 13 January. The male baby was stillborn but the female survives.

The woman, Melissa Ann Rowland, aged 28, was charged with a single count of first degree criminal homicide. She is currently in jail in lieu of $250 000 (£139 000; €204 000) bond. …
Wild-Type and Mutant HCN Channels in a Tandem Biological-Electronic Cardiac Pacemaker
Authors: Annalisa Bucchi, Alexei N. Plotnikov, Iryna Shlapakova, Peter Danilo, Yelena Kryukova, Jihong Qu, Zhongju Lu, Huilin Liu, Zongming Pan, Irina Potapova, Bruce Ken Knight, Steven Girouard, Ira S. Cohen, Peter R. Brink, Richard B. Robinson, Michael R. Rosen
Journal: Circulation (2006)

Background— Biological pacemakers (BPM) implanted in canine left bundle branch function competitively with electronic pacemakers (EPM). We hypothesized that BPM engineered with the use of mE324A mutant murine HCN2 (mHCN2) genes would improve function over mHCN2 and that BPM/EPM tandems confer advantage over either approach alone. Methods and Results— In cultured neonatal rat myocytes, activation midpoint was −46.9 mV in mE324A versus −66.1 mV in mHCN2 ( P &lt;0.05). mE324A manifested a positive shift of voltage dependence of gating kinetics of activation and deactivation compared with mHCN2 ( P &lt;0.05) in myocytes as well as Xenopus oocytes. In intact dogs in complete atrioventricular block, saline (control), mHCN2, or mE324A virus was injected into left bundle branch, and EPM were implanted (VVI 45 bpm). Twenty-four–hour ECGs were monitored for 14 days. With EPM discontinued, there was no difference in duration of overdrive suppression among groups. However, basal heart rates in controls were less than those in mHCN2, which did not differ from those in E324A (45 versus 57 versus 53 bpm; P &lt;0.05). When spontaneous rate fell below 45 bpm, EPM intervened at that rate, triggering 83% of beats in control, contrasting ( P &lt;0.05) with 26% (mHCN2) and 36% (mE324A). On day 14, epinephrine (1 μg/kg per minute IV) induced a 50% heart rate increase in all mE324A, one third of mHCN2, and one fifth of control ( P &lt;0.05 mE324A versus control or mHCN2). Conclusions— mE324A induces faster, more positive pacemaker current activation than mHCN2 and stable, catecholamine-sensitive rhythms in situ that compete with EPM comparably but more catecholamine responsively than mHCN2. BPM/EPM tandems function reliably, reduce the number of EPM beats, and confer sympathetic responsiveness to the tandem.
On Specialization and Gastroenterology
Authors: Joseph B. Kirsner
Journal: JAMA (1960)

A renewed and productive interest has developed in disorders of the digestive system. Gastroenterology today offers unparalleled opportunities for comprehensive clinical activity and for significant research. In gastroenterology the science and the art of medicine are indivisibly combined. Gastroenterologic diseases encompass many problems of internal medicine and important aspects of surgery. The well-trained gastroenterologist must acquire knowledge of other disciplines in addition to his own. He must combine a broad technical knowledge with a responsible, humane attitude toward people. His work can never be a narrow specialty, for it is too clearly related to many other important fields of medicine.
Interleukin-induced increase in Ia expression by normal mouse B cells.
Authors: N W Roehm, H J Leibson, A Zlotnik, J Kappler, P Marrack, J C Cambier
Journal: The Journal of Experimental Medicine (1984)

The constitutive culture supernatant (SN) of the macrophage tumor line P388D1 (P388 SN) and the concanavalin A (Con A)-induced culture supernatant of the T cell hybridoma FS6-14.13 (FS6 Con A SN) were shown to contain nonspecific factors capable of inducing increased Ia expression by normal resting B cells in a dose-dependent manner. In six consecutive experiments the relative increase in Ia expression induced by P388 SN was 4.9 +/- 0.9, with FS6 Con A SN 10.7 +/- 1.5, and with a combination of both preparations 13.0 +/- 1.7. This increase in Ia expression was observed to occur in virtually all the B cells, reaching maximum levels within 24 h of culture. The interleukin-induced increase in B cell Ia expression occurred in the absence of ancillary signals provided by ligand-receptor Ig cross-linking and despite the fact that virtually all the control B cells, cultured in the absence of factors, remained in G0. These results suggest that functional receptors for at least some interleukins are expressed on normal resting B cells and their effects can be manifest in the absence of additional activating signals. The increased Ia expression induced by the nonspecific factor preparations was shown to be correlated with enhanced antigen-presenting capacity by the B cells to T cell hybridomas. The nature of the interleukins responsible for these effects remains to be definitively determined, however, the activity of FS6 Con A SN was shown to correlate with B cell growth factor activity and increased B cell Ia expression was not observed using interleukin 2 (IL-2) or interferon-gamma, prepared by recombinant DNA technology.
Beware of TIPPSters.
Authors: A Gimson
Journal: Gut (1996)

<h3>Background</h3> The HIV epidemic is very heterogeneous at the district level in the four Southern states of India most affected by the epidemic and where transmission is mainly heterosexual. The authors carried out an ecological study of the relationship between high-risk population parameters and HIV prevalence among pregnant women (ANC HIV prevalence). <h3>Methods</h3> The data used in this study included: ANC HIV prevalence available from the National AIDS Control Organization (dependent variable); data on prevalence of HIV and other sexually transmitted infections among female sex workers (FSWs), their clients and high-risk men who have sex with men (HR-MSM) from studies carried out in 24 districts under Avahan; data on clients9 volume reported by FSWs and on the size estimates of FSWs and HR-MSM in each district; and census data. The latter two sets of data were used to estimate the percentage of female (male) adults who are FSWs (HR-MSM). The latter was also multiplied by HIV prevalence in FSWs (HR-MSM) to obtain the percentage of HIV-positive FSWs (HR-MSM) in the adult female (male) population. Linear regression was used for statistical analyses. <h3>Results</h3> In univariate analyses, HIV (r=0.59, p=0.002) and HSV-2 (r=0.49, p=0.014) prevalence among FSWs and mean number of clients in the last week reported by FSWs (r=0.43, p=0.036) were significant predictors of ANC HIV prevalence. In multivariate analysis, only FSW HIV prevalence remained significant. <h3>Conclusions</h3> This ecological study suggests that there is a link between HIV prevalence among FSWs and the spread of HIV to the general population in Southern India. Such an observation supports the rationale of interventions targeted at the sex industry.
Reversible Wenckebach Type Atrioventricular Block Associated with Severe Coronary Artery Disease
Authors: HERSHEL JICK, ARTHUR J. LINENTHAL
Journal: Circulation (1959)

A patient with severe angina pectoris and congestive heart failure had chronic Wenckebach-type atrioventricular block and episodes of syncope. Atropine abolished the block and prevented the Stokes-Adams attacks. Carotid sinus pressure, digoxin, and exercise increased the block; atropine prevented these effects.