tbuckley/cabot-search huggingface dataset:
Inequalities in reported use of breast and cervical screening in Great Britain: analysis of cross sectional survey data
Authors: K. Moser, J. Patnick, V. Beral
Journal: BMJ (2009)

<b>Objective</b> To investigate the relation between women’s reported use of breast and cervical screening and sociodemographic characteristics. <b>Design</b> Cross sectional multipurpose survey. <b>Setting</b> Private households, Great Britain. <b>Population</b> 3185 women aged 40-74 interviewed in the National Statistics Omnibus Survey 2005-7. <b>Main outcome measures</b> Ever had a mammogram, ever had a cervical smear, and, for each, timing of most recent screen. <b>Results</b> 91% (95% confidence interval 90% to 92%) of women aged 40-74 years reported ever having had a cervical smear, and 93% (92% to 94%) of those aged 53-74 years reported ever having had a mammogram; 3% (2% to 4%) of women aged 53-74 years had never had either breast or cervical screening. Women were significantly more likely to have had a mammogram if they lived in households with cars (compared with no car: one car, odds ratio 1.67, 95% confidence interval 1.06 to 2.62; two or more cars, odds ratio 2.65, 1.34 to 5.26), and in owner occupied housing (compared with rented housing: own with mortgage, odds ratio 2.12, 1.12 to 4.00; own outright, odds ratio 2.19, 1.39 to 3.43), but no significant differences by ethnicity, education, occupation, or region were found. For cervical screening, ethnicity was the most important predictor; white British women were significantly more likely to have had a cervical smear than were women of other ethnicity (odds ratio 2.20, 1.41 to 3.42). Uptake of cervical screening was greater among more educated women but was not significantly associated with cars, housing tenure, or region. <b>Conclusions</b> Most (84%) eligible women report having had both breast and cervical screening, but 3% report never having had either. Some inequalities exist in the reported use of screening, which differ by screening type; indicators of wealth were important for breast screening and ethnicity for cervical screening. The routine collection within general practice of additional sociodemographic information would aid monitoring of inequalities in screening coverage and inform policies to correct them.
Mutations in TWIST, a basic helix–loop–helix transcription factor, in Saethre-Chotzen syndrome
Authors: Timothy D. Howard, William A. Paznekas, Eric D. Green, Lydia C. Chiang, Nancy Ma, Rosa Isela Ortiz De Luna, Costanza Garcia Delgado, Mario Gonzalez-Ramos, Antoine D. Kline, Ethylin Wang Jabs
Journal: Nature Genetics (1997)
Estimates of the Cost-Effectiveness of a Single Course of Interferon-α2b in Patients with Histologically Mild Chronic Hepatitis C
Authors: William G. Bennett
Journal: Annals of Internal Medicine (1997)

Background: Chronic hepatitis C is a major cause of illness and death in the United States. Interferon-α2b can induce clinical, biochemical, and virologic remission in some patients with chronic hepatitis C, but the long-term cost-effectiveness of this treatment, particularly in patients with histologically mild disease, is unknown. Objective: To estimate the cost-effectiveness of interferon-α2b in mild chronic hepatitis C. Design: Meta-analysis of five prospective trials and cost-effectiveness analysis. Projection of the clinical and economic outcomes expected from loss of hepatitis C virus was done by using a Markov simulation. The potential effect of uncertainty in the model assumptions was tested by using sensitivity analyses. Data Sources: Search of the MEDLINE database, opinions of expert panels, hospital cost data, and adjusted physician charges. Patients: Hypothetical cohorts with histologically mild chronic hepatitis C. Intervention: The model assumed a single 6-month course of recombinant interferon-α2b. Measurements: Life expectancy, quality-adjusted life expectancy, costs, and marginal cost-effectiveness ratios from a managed care perspective. Results: In 27% of patients with mild chronic hepatitis C treated with interferon-α2b for 6 months, serum alanine aminotransferase levels permanently returned to normal and viral status remained negative. The model estimated that interferon-α2b treatment in this population should increase life expectancy by 3.1 years if given at 20 years of age, by 1.5 years at 35 years of age, and by 22 days at 70 years of age; discounted marginal cost-effectiveness ratios are $500, $1900, and $62 000 per year of life gained, respectively. Varying the long-term response rates and progression rates for mild and moderate chronic hepatitis to near zero in sensitivity analyses substantially affected the results: Ratios ranged from $31 000 for a 20-year-old patient to $640 000 for a 70-year-old patient. Conclusions: On the basis of estimations in this mathematical model of the natural history of chronic hepatitis C, treating mild chronic hepatitis with interferon-α2b should prolong life expectancy at a reasonable marginal cost per year of life gained, particularly in younger patients.
Linkage of familial combined hyperlipidaemia to chromosome 1q21–q23
Authors: Päivi Pajukanta, Ilpo Nuotio, Joseph D. Terwilliger, Kimmo V.K. Porkka, Kati Ylitalo, Jussi Pihlajamäki, Aki J. Suomalainen, Ann-Christine Syvänen, Terho Lehtimäki, Jorma S.A. Viikari, Markku Laakso, Marja-Riitta Taskinen, Christian Ehnholm, Leena Peltonen
Journal: Nature Genetics (1998)
Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial
Authors: J. Achan, J. K Tibenderana, D. Kyabayinze, F. Wabwire Mangen, M. R Kamya, G. Dorsey, U. D'Alessandro, P. J Rosenthal, A. O Talisuna
Journal: BMJ (2009)

To compare the effectiveness of oral quinine with that of artemether-lumefantrine in treating uncomplicated malaria in children.Randomised, open label effectiveness study.Outpatient clinic of Uganda's national referral hospital in Kampala.175 children aged 6 to 59 months with uncomplicated malaria.Participants were randomised to receive oral quinine or artemether-lumefantrine administered by care givers at home.Primary outcomes were parasitological cure rates after 28 days of follow-up unadjusted and adjusted by genotyping to distinguish recrudescence from new infections. Secondary outcomes were adherence to study drug, presence of gametocytes, recovery of haemoglobin concentration from baseline at day 28, and safety profiles.Using survival analysis the cure rate unadjusted by genotyping was 96% for the artemether-lumefantrine group compared with 64% for the quinine group (hazard ratio 10.7, 95% confidence interval 3.3 to 35.5, P=0.001). In the quinine group 69% (18/26) of parasitological failures were due to recrudescence compared with none in the artemether-lumefantrine group. The mean adherence to artemether-lumefantrine was 94.5% compared with 85.4% to quinine (P=0.0008). Having adherence levels of 80% or more was associated with a decreased risk of treatment failure (0.44, 0.19 to 1.02, P=0.06). Adverse events did not differ between the two groups.The effectiveness of a seven day course of quinine for the treatment of uncomplicated malaria in Ugandan children was significantly lower than that of artemether-lumefantrine. These findings question the advisability of the recommendation for quinine therapy for uncomplicated malaria in Africa.ClinicalTrials.gov NCT00540202.
923-6 Intravenous Adenosine and Lidocaine to Limit Reperfusion Injury During Acute Myocardial Infarction: Preliminary Data
Authors: Kirk N. Garratt, Raymond J. Gibbons, Guy S. Reeder, Dennis A. Laudon, Joseph K. Lobl, David R. Holmes
Journal: Journal of the American College of Cardiology (1995)
GMC says hospital at fault for failing to support cancer screening service
Authors: Owen Dyer
Journal: BMJ (2007)

A consultant radiologist who failed to carry out breast examinations according to NHS guidelines was last week allowed to continue working under conditions, after a General Medical Council fitness to practise hearing found his employer had failed to provide adequate resources and support.

Lan Keng Lun missed warning signs and failed to carry out standard procedures on Ms A, a patient referred to him after an abnormal mammography result in March 2003. She was diagnosed as having breast cancer seven months later. Independent experts who reviewed the case for the GMC concluded that a proper examination would …
Impact of serum storage conditions on microRNA stability
Authors: S Grasedieck, N Schöler, M Bommer, J H Niess, H Tumani, A Rouhi, J Bloehdorn, P Liebisch, D Mertens, H Döhner, C Buske, C Langer, Florian Kuchenbauer
Journal: Leukemia (2012)
Does Radioiodine Treatment Change the Methylene Diphosphonate Uptake in a Toxic Thyroid Nodule on Bone Scintigraphy?
Authors: Mehmet Mulazmoglu, Savas Karyagar, Sevda Saglampnar, Tevfik Ozpacac
Journal: Clinical Nuclear Medicine (2008)

A 46-year-old woman underwent a whole-body bone scan with Tc-99m methylene diphosphonate for evaluation of breast cancer metastasis. This study revealed intense focal uptake in the left lower neck and without any pathologic uptake compatible with metastasis. Additional history, physical examination, thyroid scintigraphy, and thyroid ultrasonography revealed hyperthyroidism due to a large toxic nodule consisting of multiple macro and micro calcifications in the left lobe of the thyroid. She received 30 mCi of I-131. Two years later, while the patient was in a euthyroid status, she underwent a whole-body bone scan because of bone pain. This study also revealed intense focal uptake in the left lower neck without any other pathologic uptake.
67 Ga-Citrate Scintigraphy: An Early Diagnostic Aid in Occult Neoplasm
Authors: KAIROON M. ALLY, STEPHEN P. BARTOK, ROBERT P. CHANDLER, LINDA L. HOWARD
Journal: Clinical Nuclear Medicine (1976)

A patient presenting with a classical clinical picture of dermatomyositis displayed abnormal 67Ga localization in the mediastinum during search for an occult neoplasm. The 67Ga-citrate abnormality was demonstrated at least eight weeks before repeated tomograms of the chest revealed presence of a mass lesion in the mediastinum. This was confirmed by mediastinal biopsy to be an undifferentiated carcinoma of the oat cell type. The usefulness of 67Ga-citrate scintigraphy as an early sensitive and non-invasive diagnostic aid was again demonstrated.
La dialectique du faire et du dire en pathologie et en thérapeutique
Authors: P. Dubor
Journal: Psychotherapy and Psychosomatics (1978)

Research Articles| February 16 2010 La dialectique du faire et du dire en pathologie et en thérapeutique: L'expression agie (extrajection réïfiante): temps premier et fondateur de la mentalisation Subject Area: Psychiatry and Psychology P. Dubor P. Dubor Lyon Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1978) 29 (1-4): 276–281. https://doi.org/10.1159/000287141 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation P. Dubor; La dialectique du faire et du dire en pathologie et en thérapeutique: L'expression agie (extrajection réïfiante): temps premier et fondateur de la mentalisation. Psychother Psychosom 31 December 1978; 29 (1-4): 276–281. https://doi.org/10.1159/000287141 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1978Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Indicators of ocean health and human health: developing a research and monitoring framework.
Authors: Anthony Knap, Eric Dewailly, Chris Furgal, Jennifer Galvin, Dan Baden, Robert E Bowen, Michael Depledge, Linda Duguay, Lora E Fleming, Tim Ford, Fredricka Moser, Richard Owen, William A Suk, Umit Unluata
Journal: Environmental Health Perspectives (2002)

We need to critically assess the present quality of the marine ecosystem, especially the connection between ecosystem change and threats to human health. In this article we review the current state of indicators to link changes in marine organisms with eventual effects to human health, identify research opportunities in the use of indicators of ocean and human health, and discuss how to establish collaborations between national and international governmental and private sector groups. We present a synthesis of the present state of understanding of the connection between ocean health and human health, a discussion of areas where resources are required, and a discussion of critical research needs and a template for future work in this field. To understand fully the interactions between ocean health and human health, programs should be organized around a "models-based" approach focusing on critical themes and attributes of marine environmental and public health risks. Given the extent and complex nature of ocean and human health issues, a program networking across geographic and disciplinary boundaries is essential. The overall goal of this approach would be the early detection of potential marine-based contaminants, the protection of marine ecosystems, the prevention of associated human illness, and by implication, the development of products to enhance human well-being. The tight connection between research and monitoring is essential to develop such an indicator-based effort.
Points from Letters: "Wasteful Practices"
Authors: R. W. Green
Journal: BMJ (1975)

Ketoprofen, one of the many propionic acid derivatives flooding the market, is the subject of another substantial promotional programme only 12 months after the first. . ..Pharmaceutical companies, it seems, are playing into the hands of "Bennery" witlh such blatant "burning" of profits.. The public can hardly be expected to support the call for more money for the N.H.S. when it seems the medical profession is doing little to discourage such wasteful practices....
TCTAP A-108 Initial Experience of Rheolytic Thrombectomy for Acute Thrombotic Lesions in Peripheral Vascular Disease
Authors: Jang Yong Kim, Young Kyun Kim, Keun-Myoung Park, Kang Woong Jun, Mi Hyung Kim, Ji Il Kim, Sang sup Yun, Kee Chun Hong
Journal: Journal of the American College of Cardiology (2014)
Unintended consequences: might major surgery accelerate cancer?
Authors: M. S. Hofman
Journal: BMJ (2014)

Kendal and colleagues found a strong overall survival advantage at 10 years’ follow-up for patients undergoing metal-on-metal hip resurfacing compared with those undergoing total hip replacement.1 The authors analysed all cause mortality, unlike many studies, which confine research to disease specific end points, thereby masking unanticipated consequences of …
15-Lipoxygenase Immunoreactivity in Normal and in Asthmatic Airways
Authors: P. Bradding, A. E. Redington, R. Djukanovic, D. J. Conrad, S. T. Holgate
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

Products of the 15-lipoxygenase (15-LO) pathway of arachidonic acid metabolism such as the mono- and di-hydroxyeicosatetraenoic acids (HETEs) may contribute to the pathophysiology of allergic airway inflammation through the recruitment and activation of inflammatory cells and stimulation of glandular secretion. In this study we have examined the expression of 15-LO and its cellular localization in the asthmatic and normal bronchial mucosa. Bronchial mucosal biopsies were obtained by fiberoptic bronchoscopy from 10 patients with symptomatic allergic asthma and six normal control subjects and processed into glycolmethacry-late resin. Sections 2 µm thick were immunostained using a specific rabbit polyclonal antihuman 15-LO antibody. Strong immunoreactivity for 15-LO was present throughout the epithelium in both the asthmatic and the normal subjects, with no difference between the two groups. Cells expressing 15-LO immunoreactivity were also present in the submucosa of both groups, with a significantly greater number present in the asthmatic group (median, 15.3 cells/mm2) than in the normal group (median, 6.9 cells/mm2) (p = 0.01). The majority (85%) of the submucosal 15-LO+ cells were eosinophils. Patchy 15-LO immunoreactivity was also seen in the vascular endothelium in both groups. These findings demonstrated increased 15-LO expression in the bronchial submucosa of asthmatic subjects, and they suggest that 15-LO products in asthma originate from both bronchial epithelium and infiltrating eosinophils.
Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels
Authors: Emiko Noguchi, Masanao Shibasaki, Michiharu Inudou, Masashi Kamioka, Yukako Yokouchi, Kimiko Yamakawa-Kobayashi, Hideo Hamaguchi, Akira Matsui, Tadao Arinami
Journal: Journal of Allergy and Clinical Immunology (2001)
Abstract P2-14-06: Characterization of risk factors in breast cancer young adult patients
Authors: G Encinas, MDPE Diz, EC Lyra, MLH Katayama, FS Pasini, MM Brentani, R Chammas, JCGS Góes, MAAK Folgueira
Journal: Cancer Research (2013)

Abstract Background: Breast cancer diagnosis in the age group of 20-34 years represents 4% of breast cancer cases diagnosed at all ages in São Paulo state, Brazil. Risk factors in this age group of patients are little understood, especially in those not reporting familial history of breast/ovarian cancer syndrome (BOCS). Identification of predisposing factors and BRCA1/2 mutations (mut) in young Brazilian patients may contribute to characterize women with increased risk of breast cancer. Objective: Characterize familial history and risk factors for breast cancer in young adult Brazilian patients and germline mutations in BRCA1/2 genes. Methodology: Forty-five patients diagnosed with breast cancer at ages 18-35 years were interviewed using a comprehensive questionnaire. Genomic DNA was extracted from peripheral blood and BRCA1/2 mut were screened by Sanger sequencing of coding sequences, analyzed through Mutation Surveyor v.3.20 and searched in BIC Database, LOVD, LOVD-IARC and UMD. Results: Mean age of patients at time of diagnosis was 33 y (24-35y); mean age of menarche was 13 y (8-19y); 32 (71.1%) patients had at least one born child, median age of first pregnancy was 22 years; 86.7% never smoked; 71.1% were no regular alcoholic drinkers; mean of body mass index was 27.14 (overweight). Most patients were diagnosed with invasive ductal carcinoma (91.1%); grades II or III (95.5%); ER/PR positive (57.8%); triple-negative (TN: 31.1%) or HER2 positive (17.8%). Among them, 22.2% reported positive familial history (NCCN criteria for BOCS). Deleterious mutation in BRCA1/2 genes was found in 17.8% of the patients (BRCA1, n = 3; BRCA2, n = 5). Among 10 and 35 patients reporting or not BOCS familial history, 3 (30%) and 5 (14.3%) respectively, had BRCA1/2mut. All BRCA1mut patients had TN tumors; BRCA2mut patients had ER/PR positive (60%), HER2 positive (20%) or TN tumors (20%). Most patients reported one or two of the following risk factors: early menarche (&amp;lt;12y); current/previous use of oral contraceptive; no breast feeding and no parities. Among 30 patients reporting no familial history and presenting BRCA1/2 wild type, six (20%) and four (13.3%) reported three or four of these risk factors, respectively. Considering breast cancer protective factors, 17.8% of the patients breast fed &amp;gt;16 months and 24.4% were aged &amp;lt;20y at birth of first child. Diet habits are being analyzed. Conclusion: In young adults with breast cancer there is a trend towards a higher rate of positive familial history among whom there is a trend towards a higher chance of BRCA1/2 mutation. A better characterization of patients reporting no familial history is urgently needed. Financial Support: FAPESP. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P2-14-06.
THE SURGERY OF TUBERCULOUS GLANDS
Authors: A. Neve
Journal: BMJ (1914)

THIS paper is based upon 800 cases operated upon in the Kashmir Mission Hospital.The climate of Kasnimir is almost European, and the people are Aryans, but there are great differences in social conditions.The urban population is crowded, with much poverty and no sanitation, but food is cheap, and sunlighlt abundanit.
Book: The Multi-Agency Approach to Domestic Violence: New Opportunities, Old Challenges
Authors: J. Richardson
Journal: BMJ (2000)

Eds Nicola Harwin, Gill Hague, Ellen Malos Whiting and Birch, £16.95, pp 292 ISBN 1 86177 003 0 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> First, try this. Think of a woman you know whose male partner is violent to her. Then consider the complexities that the woman faces when she tries to get help. It may be crucial to her success in escaping violence (or even surviving it) that the local housing department, police, health services, and other agencies from whom she seeks support work together effectively. As Harwin points out in her own chapter, the charity Women's Aid … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif