tbuckley/cabot-search huggingface dataset:
Urinary Sodium Excretion and Cardiovascular Events
Authors: Samuel Mann
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INTERLEUKIN-6 AND C-REACTIVE PROTEIN AND RISK FOR DEATH AND CARDIOVASCULAR EVENTS IN PATIENTS WITH ATRIAL FIBRILLATION
Authors: Julia K. Aulin, Michael D. Ezekowitz, Ulrika Andersson, Stuart J. Connolly, Kurt Huber, Paul A. Reilly, Agneta Siegbahn, Lars Wallentin, Salim Yusuf, Jonas Oldgren
Journal: Journal of the American College of Cardiology (2011)
Panti-girdle syndrome.
Authors: T K Davidson
Journal: BMJ (1972)

mean level of serum vitamin B12 among smokers is significantly less than among non-smokers.They discuss various factors which may have affected the serum B12 level, but they do not mention folate deficiency, which is common during pregnancy.Low serum Bi2 levels have been observed in over 40% of patients with megaloblastic anaemia due to folate deficiency, and the levels rise slowly to within the normal range on treatment with folic acid alone.1 2 As Dr.McGarry and Miss Andrews have not published the serum folate levels in their group of pregnant women, it is not possible to draw conclusions from the B12 levels unless all the women were taking folic acid.-Iam, etc.,
Exudative Pharyngitis Following Experimental Mycoplasma hominis Type 1 Infection
Authors: Maurice A. Mufson
Journal: JAMA (1965)

It has been known for a number of years that organisms of the genus<i>Mycoplasma</i>can produce severe and often debilitating respiratorytract disease in birds, mice, rats, goats, sheep, and cattle.<sup>1-3</sup>However, it was not until recently that a<i>Mycoplasma</i>organism was implicated in respiratory-tract disease of man.<sup>4</sup>Recently, the Eaton agent, originally recovered in eggs in 1944, was successfully cultivated in a cell-free artificial agar medium.<sup>5-7</sup>The organism propagated on agar medium was shown to be a<i>Mycoplasma</i>and was designated<i>Mycoplasma pneumoniae</i>.<sup>8</sup>Previous studies had shown that this organism was the etiologic agent of cold agglutinin-positive atypical pneumonia.<sup>9,10</sup>In addition, the agent had been associated with other milder forms of respiratorytract disease.<sup>11</sup>In part, the role of<i>M pneumoniae</i>in human respiratory disease was established during a series of studies with volunteers.<sup>12,13</sup> After the identification of the Eaton agent as a
A COMPARATIVE STUDY OF ANTIGENS FOR THE WASSERMANN REACTION
Authors: H. R. VARNEY
Journal: JAMA (1913)

HISTORICAL REVIEW  In 1901, Bordet and Gengou published the method for complement fixation, which was designed for the purpose of detecting antigens; that is, such bodies as are capable of producing antibodies, as well as a definite group of serum substances, probably amboceptors, the nature of which is not yet determined. It is possible by this method to determine, by the use of a known antigen, whether a certain serum contains the specific amboceptor, or reversely, one may determine by means of a known serum whether the substance used as antigen contains the antigen bodies. Neisser and Sachs proposed the use of this method for the differentiation of albumin. Wassermann, Neisser and Bruck were able to demonstrate, in the serum of monkeys which had been previously treated with extracts of syphilitic organs, the presence of substances which gave complement fixation with syphilitic extracts. Detre, as well as Wassermann, Neisser, Bruck
Switch from conventional to high-flux membrane reduces the risk of carpal tunnel syndrome and mortality of hemodialysis patients
Authors: Yutaka Koda, Shin-Ichi Nishi, Shigeru Miyazaki, Susumu Haginoshita, Tai Sakurabayashi, Masashi Suzuki, Shinji Sakai, Yasuko Yuasa, Yoshihei Hirasawa, Tsugio Nishi
Journal: Kidney International (1997)
Pravastatin in heterozygous familial hypercholesterolemia: Low-density lipoprotein (LDL) cholesterol-lowering effect and LDL receptor activity on skin fibroblasts
Authors: A. Gaddi, M. Arca, A. Ciarrocchi, S. Fazio, G. D'Alò, R. Tiozzo, G.C. Descovich, S. Calandra
Journal: Metabolism (1991)
Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment
Authors: Juanjuan Zhao, Zheng Zhang, Yan Luan, Zhengsheng Zou, Yanling Sun, Yonggang Li, Lei Jin, Chunbao Zhou, Junliang Fu, Bin Gao, Yangxin Fu, Fu-Sheng Wang
Journal: Hepatology (2013)

It is well established that interleukin (IL)-22 has hepatoprotective and antifibrotic functions in acute liver injury models; however, its function in patients with liver fibrosis and liver cirrhosis (LC) remains obscure. In the current study, we demonstrated that expression of numerous IL-22 pathway-associated genes was significantly up-regulated in hepatitis B virus (HBV)-infected liver tissues, compared to normal controls, through microarray analysis. In agreement with these findings, liver-infiltrating IL-22(+) cells were largely increased in HBV-infected patients with LC, compared to those without LC or healthy subjects, and were positively associated with liver fibrosis staging scores. Immunohistochemistry and flow cytometric analyses revealed that IL-22 was produced by multiple intrahepatic immune cells and, preferentially, by T-helper (Th) 17 cells in LC patients. In an HBV transgenic (Tg) mouse model of T-cell-mediated chronic liver inflammation and fibrosis, blockade of IL-22 attenuated hepatic expression of chemokine (C-X-C motif) ligand 10 and chemokine (C-C motif) ligand 20 (CCL20) and subsequently reduced Th17 recruitment and liver inflammation and fibrosis progression. In vitro treatment with IL-22 stimulated hepatic stellate cells (HSCs) to secrete several chemokines and subsequently promoted Th17 cell chemotaxis. Blocking C-X-C chemokine receptor type 3 or CCL20 reduced Th17 cell chemotaxis by IL-22-treated HSCs.IL-22 plays a pathological role in exacerbating chronic liver inflammation and fibrosis by recruiting hepatic Th17 cells in HBV-infected patients and HBV Tg mice.
Did Prescription Bias Affect Outcomes in a Study of the Relative Effectiveness of Osteoporosis Drugs?
Authors: Suzanne M. Cadarette, Jeffrey N. Katz, Daniel H. Solomon
Journal: Annals of Internal Medicine (2008)

Letters7 October 2008Did Prescription Bias Affect Outcomes in a Study of the Relative Effectiveness of Osteoporosis Drugs?Suzanne M. Cadarette, PhD, Jeffrey N. Katz, MD, MS, and Daniel H. Solomon, MD, MPHSuzanne M. Cadarette, PhDFrom Harvard Medical School, Boston, MA 02115.Search for more papers by this author, Jeffrey N. Katz, MD, MSFrom Harvard Medical School, Boston, MA 02115.Search for more papers by this author, and Daniel H. Solomon, MD, MPHFrom Harvard Medical School, Boston, MA 02115.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-7-200810070-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with and appreciate the comments by Drs. Beri and Khattri. They highlight our finding that calcitonin recipients were sicker than alendronate recipients in terms of measured variables. They also point out that bisphosphonate dosing instructions are complex, and thus frail patients may have been preferentially treated with calcitonin, administered by daily nasal spray. We agree that residual confounding could explain part of our findings, and we discussed limitations of administrative claims data in our article. Results from our theoretical sensitivity analysis showed that the higher fracture risk among calcitonin recipients compared with alendronate recipients is probably ...Reference1. Schneeweiss S. Sensitivity analysis and external adjustment for unmeasured confounders in epidemiologic database studies of therapeutics. Pharmacoepidemiol Drug Saf. 2006;15:291-303. [PMID: 16447304] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Harvard Medical School, Boston, MA 02115.Disclosures: Dr. Solomon has received salary support from Merck & Co. through a research grant to Brigham and Women's Hospital for unrelated work. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRelative Effectiveness of Osteoporosis Drugs for Preventing Nonvertebral Fracture Suzanne M. Cadarette , Jeffrey N. Katz , M. Alan Brookhart , Til Stürmer , Margaret R. Stedman , and Daniel H. Solomon Did Prescription Bias Affect Outcomes in a Study of the Relative Effectiveness of Osteoporosis Drugs? Abhimanyu Beri and Saakshi Khattri Metrics 7 October 2008Volume 149, Issue 7Page: 514KeywordsCalcitoninDementiaDrugsFactor analysisFallsFrailtyMedical risk factorsOsteoporosisParkinson diseaseResearch grants ePublished: 7 October 2008 Issue Published: 7 October 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Creatinine clearance in renal disease. A reappraisal
Authors: K. E. Kim, G. Onesti, O. Ramirez, A. N. Brest, C. Swartz
Journal: BMJ (1969)

To determine the validity of endogenous creatinine clearance as a measure of glomerular filtration rate in patients with renal disease 308 simultaneous determinations of inulin clearance and endogenous creatinine clearance were reviewed and analysed. The ratio of creatinine clearance/inulin clearance increased progressively with the decline in inulin clearance, while the finding of a normal endogenous creatinine clearance masked a definite but mild decrease of glomerular filtration rate in 42% of the patients and a moderate decrease of glomerular filtration rate in 23%. This indicates that with declining glomerular filtration rates the endogenous creatinine clearance progressively overestimates actual glomerular filtration rates. Hence a single determination of creatinine clearance can be misleading as a screening measurement of glomerular filtration rate.
Physician-Patient Communication in Chronic Illness
Authors: Joseph N Solowiejczyk, Lester Baker
Journal: Diabetes Care (1981)

The traditional model of doctor-patient communication allows little room for the incorporation of the expertise in self-care acquired by a patient with a chronic illness. When this knowledge is ignored or challenged, potentially damaging situations may arise. Two illustrative case reports are presented. It is suggested that the relationship between referring physician and consultant may provide a more relevant model for communication in chronic illness,
Polyplex-releasing microneedles for enhanced cutaneous delivery of DNA vaccine
Authors: Nak Won Kim, Min Sang Lee, Kyu Ri Kim, Jung Eun Lee, Kyuri Lee, Jong Sung Park, Yoh Matsumoto, Dong-Gyu Jo, Haeshin Lee, Doo Sung Lee, Ji Hoon Jeong
Journal: Journal of Controlled Release (2014)
Congenital Posterior Pharyngeal Pouch Simulating Oesophageal Atresia
Authors: B. Hutchinson-Smith
Journal: BMJ (1958)

The clinical and radiological signs of oesophageal atresia are well known and the diagnosis is not usually in doubt at the time of operation.In the case described the clinical picture of atresia of the oesophagus was simulated by a pouch of the posterior pharynx. CASE REPORTA female child, birth weight 3 lb. (1,360g.), was admitted at the age of 16 hours to the Nightingale Premature Baby Unit, Derby, on February 13, 1957.Delivery at home had been normal from a pre-eclamptic but previously healthy primipara of 23.The infant had been fed twice before admission, but no regurgitation of feed was reported.When admitted the temperature was 96°F. (35.6°C.), pulse 136, and respirations 48.The colour was good despite a copious flow of mucus from the mouth and phar%nx.Numerous rhonchi were heard over both lungs.Mucus was aspirated and no further feeds were given until February 14 (40 hours after birth), when two feeds of glucose-water were given by bottle and retained.Expressed breast milk was then oflered, but as it was regurgitated the succeeding three feeds were
Prognostic factors of chronic graft‐versus‐host disease after allogeneic blood stem‐cell transplantation
Authors: Steven Z. Pavletic, Lynette M. Smith, Michael R. Bishop, James C. Lynch, Stefano R. Tarantolo, Julie M. Vose, Philip J. Bierman, Abdul Hadi, James O. Armitage, Anne Kessinger
Journal: American Journal of Hematology (2005)

Abstract Allogeneic hematopoietic stem cells in peripheral blood transplantation (alloPBSCT) or bone marrow transplantation (alloBMT) have different biological characteristics which may affect differently prognostic factors for incidence and severity of chronic graft‐versus‐host disease (cGVHD). To determine the prognostic factors of cGVHD in patients receiving alloPBSCT, data on 87 patients who survived at least 100 days after matched related donor myeloablative transplantation were analyzed. Factors significantly associated with higher incidence of cGVHD after alloPBSCT included CMV‐positive donor, acute skin GVHD, and diagnoses other than lymphoma. Factors predictive for poor survival following cGVHD diagnosis included platelet count &lt; 100,000/mm 3 and history of acute liver GVHD. Acute liver GVHD and etoposide in the preparative regimen significantly increased risk of death due to cGVHD after alloPBSCT. All alloPBSCT multivariate models were fit to an independent cohort of comparable matched related donor alloBMT patients ( n = 75). After alloBMT, only acute skin GVHD and diagnoses other than lymphoma retained prognostic significance for predicting cGVHD. Low platelet count was the only variable predictive for poor survival in cGVHD patients after alloBMT. Acute liver GVHD was the only factor that retained prognostic significance for risk of death due to cGVHD after alloBMT. These data suggest there are some cGVHD prognostic factors that may be unique to recipients of alloPBSCT. More studies are needed to determine whether cGVHD prognostic systems should be used interchangeably in patient populations receiving different stem‐cell products. Am. J. Hematol. 78:265–274, 2005. © 2005 Wiley‐Liss, Inc.
Cerebral Hemisphere Function and Laterality of Migraine
Authors: A.H. Crisp, J. Kamen, G. Potamianos, A.V. Bhat
Journal: Psychotherapy and Psychosomatics (1985)

We report preliminary findings of a study exploring the hypothesis that migraine is the experience of a protective cerebrovascular mechanism arising in response to unilateral cerebral information overload. The necessary population to be studied, namely those with exclusive one-sided migraine, proved to be rare. The measures of cerebral hemisphere function were the verbal and non-verbal scales of Wechsler's Adult Intelligence Scale. Preliminary results suggest that it is worthwhile continuing to explore the notion using additional and more sophisticated measures.
Cryoglobulinaemia in haemophilia.
Authors: C A Lee, P B Kernoff, D K Peters
Journal: BMJ (1985)

Cryoglobulinaemia in haemophiliaMost cryoglobulins are immunoglobulins and can be classified into three types: type I, composed of monoclonal immunoglobulins; type II, containing a monoclonal component possessing antibody activity to polyclonal IgG; and type III, mixed polyclonal immunoglobulin.'We report on a patient with type III cryoglobulinaenmia who presented with vasculitis after treatment with factor VIII concentrate.
Abstract 3756: Prediction of xenograft response to MM-121, an anti-ErbB3 inhibitor, using computational modeling and measurements of five biomarkers
Authors: Matthew Onsum, Olga Burenkova, Aaron Fulgham, Lin Nie, Ashish Kalra, Dongmei Xiao, Viara Grantcharova, Sharlene Adams, Lia Luus, Violette Paragas, Raghida Bukhalid, Sharon Moulis, Lucia Wille, Gabriela Garcia, Victor Moyo, Birgit Schoeberl, Bill Kubasek, Ulrik Nielsen
Journal: Cancer Research (2010)

Abstract One of the challenges faced by targeted therapeutics currently in the clinic is the relatively small population of patients who derive significant benefit from their use. We report the development of a preclinical classifier which can correctly predict xenograft response to MM-121, an anti-ErbB3 antibody, based on the measurement of a few key biomarkers in cell lysates. Deregulation of the ErbB family receptors is common in many cancers. Using a combination of computational modeling and quantitative experiments we identified ErbB3 as a key mediator of mitogenic signaling downstream of the ErbB receptors. Based on these results, we developed MM-121, a first in class anti-ErbB3 monoclonal antibody that blocks heregulin-induced signaling and inhibits tumor growth in multiple xenograft models of human cancer. Here we present our efforts to derive a predictive biomarker signature that identifies tumors that are responsive to MM-121. Using our computational model of the ErbB signaling pathway we identified the five most critical proteins for predicting activation of phospho-AKT - a key mediator of cell survival and apoptosis. These proteins include MM-121's target, ErbB3, and its ligand, heregulin. We profiled these biomarkers in a large panel of cancer cell lines, and using the measured effect of MM-121 on inhibiting tumor growth in eight xenograft tumor models, we determined a classification rule for predicting xenograft response. We subsequently used this classification rule to correctly predict a priori MM-121 response in 11 xenograft models. These results suggest that our computationally-derived biomarker signature is sufficient for predicting response to MM-121 in xenografts, and could offer significant clinical benefit by helping select patients for MM-121 treatment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3756.
Pulmonary and Critical Care Medicine on CD-ROM
Authors: Charles G. Durbin
Journal: JAMA (1997)

The electronic explosion has resulted in a large number of medically oriented materials appearing for home computer use. Major medical book publishers have joined the rush to this market. Mosby's Pulmonary and Critical Care Medicine on CD-ROM, subtitled your single source reference library, attempts to fill the gap between the dated material in current textbooks and up-to-date journal information. This CD-ROM contains the complete text and most of the graphs and charts fromPulmonary and Critical Care Loose-leaf, Year Book of Pulmonary Medicine(1993, 1994, 1995),Year Book of Critical Care Medicine(1993, 1994, 1995), andCurrent Pulmonology(volumes 14,15,16). The major advantage of this format over print is the ability to quickly search the material in a variety of ways to retrieve and organize the information in a userdefined way. The search engine is intuitive and rapid. Highlighting, custom bookmarks, and a reader-created note file linked to the
Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis
Authors: N. Beraza, Y. Malato, S. Vander Borght, C. Liedtke, H. E. Wasmuth, M. Dreano, R. de Vos, T. Roskams, C. Trautwein
Journal: Gut (2008)

<h3>Background:</h3> Non-alcoholic-steatohepatitis (NASH) leading to fibrosis, end-stage cirrhosis and hepatocellular carcinoma is an increasing health problem in the Western world. Thus, the need for new therapeutic approaches is increasing. IKK2 plays a key role in the development of NASH by mediating inflammation and insulin resistance. <h3>Aim:</h3> Here the beneficial effects of a pharmacological IKK2 inhibitor (AS602868) on initial stages of NASH progression were tested. <h3>Methods:</h3> Mice were fed with a high sucrose diet (HSD) and daily-administered AS602868 and vehicle. The impact of AS602868 on NASH progression was studied using biochemical, histological and molecular markers. <h3>Results:</h3> AS602868 treatment prevented HSD-induced weight gain and visceral fat accumulation. In adipose tissue, AS602868-treated mice exhibited a lower degree of infiltrated macrophages along with reduced proinflammatory cytokine production. Further analysis demonstrated that AS602868 treatment efficiently inhibited nuclear factor (NF)-κB activation in liver non-parenchymal cells and as a consequence attenuated the inflammatory response in the liver. Accordingly, in HSD/AS602868 mice, liver and adipose tissue adiponectin levels remained at levels comparable with those of control chow-fed mice, while they were decreased in HSD/vehicle animals. Additionally, AS602868 improved lipid β-oxidation mediated by peroxisome proliferator-activated receptor (PPAR) α and PPARγ. Systemic pharmacological IKK2 inhibition by AS602868 treatment efficiently prevented liver steatosis and inflammation, and improved antioxidant response. All this contributed to attenuation of NASH progression as evidenced by lower hepatocyte apoptosis and early stages of liver fibrosis. <h3>Conclusion:</h3> The data demonstrate that AS602868-mediated IKK2 inhibition represents a new therapeutic approach to prevent dietary-induced NASH progression.
Prognosis and treatment of idiopathic facial (Bell's) palsy.
Authors: D Taverner, F Kemble, S B Cohen
Journal: BMJ (1967)

Fourteen of these patients recovered more than 90% of their normal function.Overall Outcome.-Theresults can best be illustrated by contrasting them with the null hypothesis that neither the prognostic testing nor the treatment had any influence what- ever on the outcome.In a series of controlled therapeutic trials over many years we have repeatedly found that the proportion of unselected patients with idiopathic facial palsy developing denervation, using the very strict criteria here applied, is very
Serum protein adsorption and platelet adhesion on pluronic™-adsorbed polysulfone membranes
Authors: Akon Higuchi, Kaichiro Sugiyama, Boo Ok Yoon, Masaru Sakurai, Mariko Hara, Masaya Sumita, Shu-ichi Sugawara, Takashi Shirai
Journal: Biomaterials (2003)