tbuckley/cabot-search huggingface dataset:
Evidence for an immunological attack on the placenta in pemphigoid gestationis
Authors: Gillian Borthwick, Frances Lawlori, R.C. Holmes, M.M. Black, G.M. Stirrat
Journal: British Journal of Dermatology (1985)

Journal Article Evidence for an immunological attack on the placenta in pemphigoid gestationis Get access Gillian Borthwick, Gillian Borthwick Department of Obstetrics and Gynaecology, Bristol Maternity Hospital, Bristol Search for other works by this author on: Oxford Academic Google Scholar Frances Lawlori, Frances Lawlori Department of Obstetrics and Gynaecology, Bristol Maternity Hospital, Bristol Search for other works by this author on: Oxford Academic Google Scholar R.C. Holmes, R.C. Holmes Coventry and Warwickshire Hospital, Coventry Search for other works by this author on: Oxford Academic Google Scholar M.M. Black, M.M. Black Department of Dermatology, St Thomas' Hospital, London SE1 Search for other works by this author on: Oxford Academic Google Scholar G.M. Stirrat G.M. Stirrat Department of Obstetrics and Gynaecology, Bristol Maternity Hospital, Bristol Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Pages 41–42, https://doi.org/10.1111/j.1365-2133.1985.tb13009.x Published: 01 July 1985
Genetic rearrangement of FOXP1 is predominantly detected in a subset of diffuse large B-cell lymphomas with extranodal presentation
Authors: E Haralambieva, P Adam, R Ventura, T Katzenberger, J Kalla, S Höller, M Hartmann, A Rosenwald, A Greiner, H K Műller-Hermelink, A H Banham, G Ott
Journal: Leukemia (2006)
Blood sugar and beta-blockers.
Authors: S P Deacon
Journal: BMJ (1976)

results obtained in the treatment of hyper- glycaemic diabetic men by the recommended weight-maintaining American Diabetes Asso- ciation (ADA) diet with an isocaloric high unrefined carbohydrate diet.The ADA diet contained refined starch 23%, sucrose 20%, fat 340/, protein 23%, crude fibre 4-7 g/d.The high unrefined carbohydrate diet con- tained unrefined starch 55%, sucrose 20%, fat 9%, protein 16%, crude fibre 15 g/d.Daily estimations of fasting plasma glucose moni- tored the response and permitted a safe re- duction of insulin or hypoglycaemic agent in many patients.Among 13 hyperglycaemic diabetic patients who ate the high carbo- hydrate diet for two weeks five insulin-treated men, previously receiving for many years from 15 to 25 units a day, had insulin discontinued, and all five sulphonylurea-treated men had this therapy discontinued.Three men, pre- viously receiving a higher dose of insulin from 40 to 55 units a day, remained unaltered in their requirements.Mean fasting serum cholesterol and triglyceride levels both fell significantly.Two patients could not tolerate the high- carbohydrate low-fat diet, but only one patient chose not to continue the diet as an outpatient.The main difficulty in eating this diet is one of unpalatability; fat is very low at 9%, sugar is high at 20%, so is protein at 16%.A more palatable diet would be unrefined starch 5000, fat 20%, sugar 15%,, protein 15%.Refractory patients might benefit by further increases of unrefined starch but decreases of fat and sugar, but such a diet is less palatable.The dietary change may be sudden or gradual.If gradual, then fat and sucrose percentages of the pre- vious diet could be decreased stepwise and the unrefined starch increased to equalise the calories.Careful questioning would reveal whether fat is missed more than sucrose and would constitute a guide to future stepwise reductions.Unrefined high-fibre starchy foods should come from a wide variety of sources and the scanty fat and sucrose diverted to increase their palatability.Wholemeal bread and flour, potatoes, ryemeal crispbread, whole- grain breakfast cereals rather than those enriched with bran, whole maize, brown rice, bananas, beans, and peas offer a wide choice.
CLASSIFICATION OF THE HEMOLYTTC STREPTOCOCCI BY THE PRECIPITIN REACTION
Authors: Charles H. Hitchcock
Journal: The Journal of Experimental Medicine (1924)

A method is described for the preparation from hemolytic streptococci of extracts containing a soluble precipitating substance. By the use of such extracts, it is shown that nearly all members of this family yield a common precipitable substance. So far, therefore, as concerns the precipitin reaction, the hemolytic streptococci form a practically homogeneous group.
Effects of exogenous oxygen derived free radicals on myocardial capillary permeability, vascular tone, and incidence of ventricular arrhythmias in the canine heart
Authors: J. H. Svendsen, P. J Bjerrum
Journal: Cardiovascular Research (1992)

Objective: The aim was to examine the effects of exogenous oxygen derived free radicals on myocardial capillary permeability for a small hydrophilic indicator, postischaemic vascular tone, and the occurrence of arrhythmias in the canine heart in vivo. Methods: Free radicals were generated by simultaneous intracoronary infusion of hypoxanthine and xanthine oxidase into normally perfused myocardium, and at reperfusion following five minutes of coronary occlusion, respectively, in 20 anaesthetised open chest dogs. Myocardial capillary extraction for 99mTc-DTPA, plasma flow rate, and the interstitial washout rate constant were measured by the single injection, residue detection method, and the capillary permeability-surface area product (PS) was calculated. The maximum plasma flow during reactive hyperaemia was measured by the local 133Xe washout method. Results: Hypoxanthine and xanthine oxidase infusion into normally perfused myocardium induced a 15% decrease in capillary extraction (p=0.05), a 24% decrease in PS (p<0.01), and a 23% decrease in the interstitial washout rate constant (NS) two minutes after the end of the infusion. When hypoxanthine and xanthine oxidase were infused into postischaemic myocardium, 86% of animals developed sustained ventricular arrhythmias, in contrast to none in control experiments (p<0.05). The maximum plasma flow was 363% of preocclusive values in control experiments v 268% in hypoxanthine + xanthine oxidase experiments (p<0.05). Conclusions: In normally perfused hearts, intracoronary infusion of hypoxanthine and xanthine oxidase induce a decreased capillary extraction, suggesting a reduced capillary surface area. In postischaemic myocardium these substances cause a decreased vasodilatation in the initial phase of reactive hyperaemia, and induce ventricular arrhythmias. Cardiovascular Research 1992;26:1181-1188
Automatic Defibrillator Causes a Pain in the Neck
Authors: Michael D. Partington
Journal: JAMA (1990)

<h3>To the Editor.—</h3> We read the recent article on automatic implantable cardioverter defibrillators (AICDs) by Manolis et al<sup>1</sup>with interest and report an unusual complication of a normally functioning AICD. <h3>Report of a Case.—</h3> A 53-year-old man came to this institution for evaluation of pain in the right arm of recent onset. One year previously he had undergone implantation of an AICD elsewhere for recurrent episodes of syncope with ventricular tachycardia. Seven weeks prior to our evaluation, the device discharged, resulting in a blow to the chest of sufficient force to cause him to fall off his chair. The next day he developed pain in the right posterior and lateral areas of the neck that radiated into the right upper arm. This was accompanied by paresthesias in the fourth and fifth fingers. Over the next few weeks, he became increasingly aware of difficulty grasping objects in his right
Eosinophilic pustular folliculitis in infancy: report of two affected brothers
Authors: A.S. DUPOND, F. AUBIN, Y. BOUREZANE, B. FAIVRE, H.VAN LANDUYT, PH. HUMBERT
Journal: British Journal of Dermatology (2006)

We describe two brothers with eosinophilic pustular folliculitis. Both had recurrent crops of papules and pustules, primarily affecting the scalp. The eruption began in the neonatal period. Both children had a leucocytosis with eosinophilia. Histology revealed folliculitis, with an infiltrate in which eosinophils were predominant. Bacteriological and fungal cultures of pustules were negative. There was a good clinical response to treatment with a topical corticosteroid and dapsone. We review the 28 previously reported cases of eosinophilic pustular folliculitis in infancy. The occurrence of this disorder in brothers suggests that an inherited or contagious factor may be involved in its aetiology.
THE BIOLOGIC SIGNIFICANCE OF THE FEMALE REPRODUCTIVE CYCLE
Authors: EMIL NOVAK
Journal: JAMA (1931)

Gynecology is becoming less and less a purely surgical specialty. Its early history is a record of brilliant achievement in the development of operative procedures, and a subsequent generation has added comparatively little to this branch of our work. Following this purely clinical era came a period in which important contributions were made to the pathology of gynecologic disease, and pathology is still, and always will be, a sine qua non in the proper training of the gynecologist. During recent years the line of advance has again shifted, for certainly at the present time physiology must be recognized as the growing margin of our specialty. It is true that much of the advance in the field of reproductive physiology would scarcely have been possible except for the help of our allies, the anatomists and the physiologists. The results already achieved in this field have completely changed our concepts concerning many
A New Flexible Forceps for the Removal of Polyps from the Gastrointestinal Tract after Successful Endoscopic Polypectomy
Authors: E. Seifert
Journal: Endoscopy (1972)

A new flexible forceps constructed by us (produced by Wolf Comp., Knittlingen, W.-Germany) permits the safe fixation and removal of polyps from the gastrointestinal tract after successful endoscopic polypectomy. Instrument and technique are described. Untill now, by this method we removed 15 polyps from the stomach and 4 from the esophagus without failure.
Intensive Insulin Therapy Reduces Counterregulatory Hormone Responses to Hypoglycemia in Patients with Type I Diabetes
Authors: DONALD C. SIMONSON
Journal: Annals of Internal Medicine (1985)

Counterregulatory hormone responses to hypoglycemia were examined in six healthy controls and in six patients with type I diabetes before and after 4 to 8 months of insulin pump treatment. The insulin clamp technique was used to provide an identical hypoglycemic stimulus (about 50 mg/dL) in each study group. Before pump treatment, the release of counterregulatory hormones (except glucagon) during the hypoglycemic period was not significantly different in diabetics from that in normal controls. However, when values before and after pump treatment in diabetics were compared, there were significant reductions in epinephrine (304 ±70 and 127 ±43 pg/mL;p < 0.01), growth hormone (45 ±12 and 18 ± 5 ng/mL;p < 0.05), and cortisol (20 ±3 and 10 ±2 µg/dL;p < 0.01) levels during hypoglycemia. Defective glucagon release during hypoglycemia in the diabetics was not corrected by pump treatment. Intensive insulin treatment of patients with type I diabetes causes a generalized reduction in counterregulatory hormone release after a moderate fall in blood glucose levels. This reduction may impair glucose counterregulation and diminish perception of hypoglycemia, thereby increasing the risk of hypoglycemic episodes.
Reporting of outcomes in arthritis trials measured on ordinal and interval scales is inadequate in relation to meta-analysis
Authors: P C Gotzsche
Journal: Annals of the Rheumatic Diseases (2001)

<h3>OBJECTIVES</h3> To study whether the reporting of clinical outcomes in arthritis trials measured on ordinal and interval scales is adequate in relation to meta-analysis. <h3>METHODS</h3> Systematic review of randomised trials of non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis. Optimal reporting was defined as data in the original ordered categories for global evaluation and pain, and as mean and SD for number of tender joints and grip strength, and if a visual analogue scale had been used to measure pain. <h3>RESULTS</h3> A total of 144 trials were included. The median sample size was 60 patients. The quality of the reporting increased over time for three of the four variables. Global evaluation was optimally reported in 52 of the 127 trials (41%) in which it was recorded. Pain was optimally reported in 27 of 98 trials (28%), number of tender joints in 41 of 123 trials (33%), and grip strength in 34 of 124 trials (27%). Even if rather broad criteria are adopted, only about half of the data were reported in a potentially useful way for a meta-analysis. <h3>CONCLUSIONS</h3> Arthritis trials have been reported inadequately in relation to meta-analysis. As most trials are underpowered, meta-analysis is indispensable and the deficit therefore needs urgent improvement. Investigators should specify a priori what constitutes an important treatment effect and report numbers of patients improved.
Circulating levels of TNF? and TNF receptor superfamily members in lymphoid neoplasia
Authors: Sunil S. Metkar, K.N. Naresh, Partha P. Manna, V. Srinivas, S.H. Advani, J.J. Nadkarni
Journal: American Journal of Hematology (2000)

We have correlated the serum levels of TNF␣ and soluble TNF receptor superfamily members with clinico-pathologic parameters in patients of Hodgkin's disease (HD, N = 26) and non-Hodgkin's lymphoma (NHLs, N = 35).HD patients had significantly higher levels of TNF␣, sTNFRI, and sTNFRII in serum while NHL patients had significantly higher levels of sTNFRI, sTNFRII, sCD27, and sFas as compared to controls.In NHL patients the levels of sCD27 correlated directly and significantly with the high-stage disease, bone marrow involvement, lymph nodal presentation, and serum LDH levels.Similarly in NHL patients, levels of sFas also correlated directly and significantly with the presence of high stage disease.HD patients with B symptoms had significantly higher levels of sTNFRII.Am.
Distinct hematopoietic progenitor compartments are delineated by the expression of aldehyde dehydrogenase and CD34
Authors: Robert W. Storms, Patrick D. Green, Kristine M. Safford, Donna Niedzwiecki, Christopher R. Cogle, O. Michael Colvin, Nelson J. Chao, Henry E. Rice, Clayton A. Smith
Journal: Blood (2005)
Surgeons in England lobby prime minister on working hours
Authors: Susan Mayor
Journal: BMJ (2005)

Carnitine palmityl transferase I is the key enzyme in the carnitine dependent transport of long chain fatty acids across the mitochondrial inner membrane and its deficiency results in a decrease rate of fatty acids beta-oxidation with decreased energy production. We reported a family of 3 affected siblings who are the product of a first degree cousin marriage. The first 2 presented with typical Reye-like syndrome with unconsciousness, hepatomegaly, hypoglycemia, hyperammonemia and very high liver enzymes. Liver biopsy showed steatosis. On screening of the complete family, the 3rd sibling was found to have hepatomegaly. The 3 siblings showed an acyl carnitine profile with very high free carnitine with almost absent long chain acyl carnitines, suggestive of carnitine palmityl transferase I deficiency. This was confirmed by enzyme analyses in fibroblast cultures. These patients were effectively treated with a diet high in carbohydrate, low in long chain fatty acids with medium chain triglycerides. In conclusion, carnitine palmityl transferase I deficiency is an important cause of Reye-like syndrome, which may be treated easily with very good results if detected early in life.
BENEFITS OF COMBINED AEROBIC/RESISTANCE/INSPIRATORY MUSCLE TRAINING IN PATIENTS WITH CHRONIC HEART FAILURE. THE IDEAL EXERCISE PROGRAM FOR CHF?
Authors: Dennis V.P. Cokkinos, Ioannis D. Laoutaris, Athanassios Manginas, Stamatis Adamopoulos, Manolis S. Kallistratos, Constantinos Doulaptsis, Gregory Pavlides, Athanasios Dritsas
Journal: Journal of the American College of Cardiology (2011)
Acetylcholinesterase and butyrylcholinesterase genes coamplify in primary ovarian carcinomas.
Authors: H Zakut, G Ehrlich, A Ayalon, C A Prody, G Malinger, S Seidman, D Ginzberg, R Kehlenbach, H Soreq
Journal: Journal of Clinical Investigation (1990)

The genes for acetylcholinesterase (ACHE) and butyrylcholinesterase (CHE) are expressed in multiple tumor tissues, including ovarian carcinomas. Both CHE and ACHE genes coamplify in leukemias. To examine the relationship of gene amplification to the expression of these genes in tumors, ACHE and CHE genes and their expression were studied in primary ovarian carcinomas. DNA blot hybridization demonstrated a significant amplification and mutagenesis of both genes in 6 of 11 malignant tumors studied. This was greater or of the same order of magnitude as the amplification of the oncogenes c-rafi, v-sis, and c-fes in these tumors. No amplification was found in normal ovarian tissues or benign ovarian cysts. Xenopus oocyte microinjections, blot and in situ hybridizations, and immuno- and cytochemical staining revealed translatable CHEmRNA and its active protein product in discrete tumor foci. The frequent coamplification in ovarian carcinomas of ACHE and CHE genes implicates cholinesterases in neoplastic growth and/or proliferation.
The importance of low blood urea nitrogen levels in pregnant patients undergoing hemodialysis to optimize birth weight and gestational age
Authors: Yukari Asamiya, Shigeru Otsubo, Yoshio Matsuda, Naoki Kimata, Kan Kikuchi, Naoko Miwa, Keiko Uchida, Michio Mineshima, Minoru Mitani, Hiroaki Ohta, Kosaku Nitta, Takashi Akiba
Journal: Kidney International (2009)
Retinal Detachment and Vitreous Hemorrhage due to Talc Emboli
Authors: L. Lothaire Bluth
Journal: JAMA (1981)

INTRAOCULAR talc particles have been described after intravenous (IV) injection of dissolved methylphenidate hydrochloride tablets.<sup>1,2</sup>Presumably the talc, which is used as a filler in the methylphenidate tablet, is captured in the retinal capillaries, usually in the macular region. Although mild reductions in visual acuity after a talc injection have been reported,<sup>3</sup>in most cases visual acuity has been normal. We report a case of bilateral severe visual loss secondary to talc emboli. <h3>Report of a Case</h3> A 42-year-old black man was seen in December 1979 complaining of decreased vision. A "curtain" had descended into his visual field five days previously, but the patient could not tell if it was noted while using the right or left eye. The patient had been a heroin addict from 1968 to 1976. He then changed to IV injections of dissolved methylphenidate tablets, injecting from two to six tablets a day. He
Angiotensin II Blockade Reverses Myocardial Fibrosis in a Transgenic Mouse Model of Human Hypertrophic Cardiomyopathy
Authors: Do-Sun Lim, Silvia Lutucuta, Pavan Bachireddy, Keith Youker, Alida Evans, Mark Entman, Robert Roberts, Ali J. Marian
Journal: Circulation (2001)

Background —Hypertrophic cardiomyopathy (HCM), the most common cause of sudden cardiac death in the young, is characterized by cardiac hypertrophy, myocyte disarray, and interstitial fibrosis. We propose that hypertrophy and fibrosis are secondary to the activation of trophic and mitotic factors and, thus, potentially reversible. We determined whether the blockade of angiotensin II, a known cardiotrophic factor, could reverse or attenuate interstitial fibrosis in a transgenic mouse model of human HCM. Methods and Results —We randomized 24 adult cardiac troponin T (cTnT-Q 92 ) mice, which exhibit myocyte disarray and interstitial fibrosis, to treatment with losartan or placebo and included 12 nontransgenic mice as controls. The mean dose of losartan and the mean duration of therapy were 14.2±5.3 mg · kg –1 · d –1 and 42±9.6 days, respectively. Mean age, number of males and females, and heart/body weight ratio were similar in the groups. Collagen volume fraction and extent of myocyte disarray were increased in the cTnT-Q 92 mice (placebo group) compared with nontransgenic mice (9.9±6.8% versus 4.5±2.2%, P =0.01, and 27.6±10.6% versus 3.9±2.3%, P &lt;0.001, respectively). Treatment with losartan reduced collagen volume fraction by 49% to 4.9±2.9%. The expression of collagen 1α (I) and transforming growth factor-β1, a mediator of angiotensin II profibrotic effect, were also reduced by 50%. Losartan had no effect on myocyte disarray. Conclusions —Treatment with losartan reversed interstitial fibrosis and the expression of collagen 1α (I) and transforming growth factor-β1 in the hearts of cTnT-Q 92 mice. These findings suggest that losartan has the potential to reverse or attenuate interstitial fibrosis, a major predictor of sudden cardiac death, in human patients with HCM.
Abstract 5456: Functional genomics reveals diverse cellular processes that modulate tumor cell response to oxaliplatin
Authors: Kelly Harradine, Michelle Kassner, Donald Chow, Meraj Aziz, Daniel D. Von Hoff, Joffre Baker, Hongwei Yin, Robert J. Pelham
Journal: Cancer Research (2011)

Abstract Oxaliplatin is widely used to treat colorectal cancer, as both adjuvant therapy for resected disease and palliative treatment of metastatic disease. However, a significant number of patients experience serious side effects from oxaliplatin treatment, including prolonged neurotoxicity, creating an urgent need for biomarkers of oxaliplatin response or resistance to direct therapy to those most likely to benefit. As a first step to improve selection of patients for oxaliplatin-based chemotherapy, we have conducted an in vitro cell-based small interfering RNA (siRNA) screen of 500 genes aimed at identifying genes whose loss of expression alters tumor cell response to oxaliplatin. The siRNA screen identified twenty-seven genes, that when silenced, significantly altered colon tumor cell line sensitivity to oxaliplatin. Silencing of a group of putative resistance genes increased the extent of oxaliplatin-mediated DNA damage and inhibited cell cycle progression in oxaliplatin-treated cells. The activity of several signaling nodes, including AKT1 and MEK1, was also altered. We used cDNA transfection to over-express two genes (LTBR and TMEM30A) that were identified in the siRNA screen as mediators of oxaliplatin sensitivity. In both instances, over-expression conferred resistance to oxaliplatin. In summary, this study identifies numerous putative predictive biomarkers of response to oxaliplatin which should be studied further in patient specimens for potential clinical application. Diverse gene networks appear to influence tumor survival in response to DNA damage by oxaliplatin. Finally, those genes whose loss of expression (or function) is related to oxaliplatin sensitivity may be promising therapeutic targets to increase patient response to oxaliplatin. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5456. doi:10.1158/1538-7445.AM2011-5456
THE PSYCHOPATHOLOGY OF THE HIT-AND-RUN DRIVER
Authors: LOWELL S. SELLING
Journal: American Journal of Psychiatry (1941)

We can conclude from the foregoing information that any mental deviation is likely to result in fleeing from the scene of an accident. There is a definite type of malfunction which makes certain types of unstable and otherwise psychopathic people flee from the scene of an accident—they are not conscious of the necessity of salving the damage that they have done, or they are likely to go into a flight reaction when there is no need. They evaluate features of their past or present in such a way that their thresholds of social responsibility are lowered. The solution of these problems is definitely one in which the psychiatrist should take part.
Addendum: The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia
Authors: O Levran, C Attwooll, R T Henry, K L Milton, K Neveling, P Rio, S D Batish, R Kalb, E Velleuer, S Barral, J Ott, J Petrini, D Schindler, H Hanenberg, A D Auerbach
Journal: Nature Genetics (2005)