tbuckley/cabot-search huggingface dataset:
The Medical Management of Hyperglycemia Over a 10-Year Period in People With Diabetes
Authors: Ronald Klein, Barbara E K Klein, Scot E Moss, Karen J Cruickshanks
Journal: Diabetes Care (1996)

OBJECTIVE The purpose of the study was to examine changes in the medical management of glycemia in diabetes and its relation to changes in hyperglycemia as measured by glycated hemoglobin. RESEARCH DESIGN AND METHODS A total of 765 patients with younger-onset diabetes diagnosed before 30 years of age and 533 older-onset diabetic patients participated in a population-based study in southern Wisconsin, at baseline (1980–1982), at 4 years (1984–1986), and at 10 years (1990–1992). Glycated hemoglobin, the presence of complications, and information regarding medical management of glycemia, hypoglycemic reactions, and socioeconomic factors were determined using standardized protocols at the three examinations. RESULTS In the younger-onset group, there was a significant increase (P &amp;lt; 0.001) in the use of three or more insulin injections per day or in the use of an insulin infusion pump from 3.6% of the cohort at baseline to 24.4% at the 10-year follow-up. This increase was associated with female sex, the presence of gross proteinuria, more education, and better glycemic control at baseline. In the older-onset group, there was a significant (P &amp;lt; 0.05) increase in the proportion of patients taking insulin, from 49.2% at baseline to 61.9% at the 10-year follow-up. This was associated with being younger, having a longer duration of diabetes, having higher glycated hemoglobin values, and having more education at baseline, or developing proliferative diabetic retinopathy or macular edema between baseline and the 4-year follow-up. CONCLUSIONS These data suggest a change in the pattern of use of insulin to treat people with diabetes. However, there is still a large number of individuals with poorly controlled diabetes in the population.
Abstract 5305: Transcriptionalregulation by microRNAs in NSCLC.
Authors: Sonia Molina-Pinelo, Gabriel Gutierrez-Pozo, Maria D. Pastor, Marta Hergueta, Gema Moreno-Bueno, Rocio Garcia-Carbonero, Ana BS Nogal, Rocio Suarez, Ana Salinas, Francisco Pozo-Rodríguez, Fernando Lopez-Rios, Teresa Agulló-Ortuño, Jose Palacios, Amancio Carnero, Luis G. Paz-Ares
Journal: Cancer Research (2013)

Abstract Squamous cell lung cancer and adenocarcinoma are the most common subtypes of the lung tumours. The search for cancer-directed treatments has increased the need for understanding molecular features of either histological subtypes. The aim of this study was to identify the transcriptional regulation differences due to miRNA expression profiles between SCC and adenocarcinoma. In this work, a total of 44 patients were evaluated to assess the correlation between the miRNA and messenger RNA expression levels. We detected changes in 56 mRNAs as well as in 9 miRNAs between SCC and adenocarcinoma. Nearly 20% of overall deregulated genes were targeted by at least one of the 9 miRNAs (miR-149, miR-205, miR-375, miR-378, miR-422a, miR-483-5p, miR-494, miR-601 and miR-708) differentially expressed between SCC and adenocarcinoma (table 1). Genes predicted (CEACAM6, CGN, CLDN3, ABCC3, MLPH, ACSL5, TMEM45B, MUC1) to be targeted by several miRNAs were individually validated by qRT-PCR. We found genes involved in tight junctions and others involved in resistance to anticancer agents. These genes were reliable biomarkers to detect differences between the two most common histological subtypes of lung cancer. Therefore, transcriptional regulation differences through miRNA expression play an important role in key hallmarks of non-small cell lung cancer. Citation Format: Sonia Molina-Pinelo, Gabriel Gutierrez-Pozo, Maria D. Pastor, Marta Hergueta, Gema Moreno-Bueno, Rocio Garcia-Carbonero, Ana BS Nogal, Rocio Suarez, Ana Salinas, Francisco Pozo-Rodríguez, Fernando Lopez-Rios, Teresa Agulló-Ortuño, Jose Palacios, Amancio Carnero, Luis G. Paz-Ares. Transcriptionalregulation by microRNAs in NSCLC. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5305. doi:10.1158/1538-7445.AM2013-5305
Anemia. Textbook vs practice
Authors: R. Carmel
Journal: JAMA (1979)

Anemia, particularly if mild, is ignored frequently. We conducted a questionnaire survey of 252 physicians and medical students to verify this impression and to explore the reasons for it. A cumulative 40% to 57% depending on the hypothetical patients' circumstances) of respondents chose to investigate anemia only at hemoglobin levels too low for the accepted criteria in female patients; a striking 78% to 89% did so in male patients. Only 54% and 30% knew the correct textbook definition of anemia for women and men, respectively. More importantly, 35% to 60% demonstrated criteria for choosing to investigate anemia were lower than even their own perception of the textbook definition. Little difference existed among the various physician subgroups in their responses. The discrepancy between what physicians do and what they are taught appears to arise from several factors, of which lack of knowledge is only one.
Liver/intestinal collagens type I, III and VI bind keratinocyte growth factor (KGF/FGF-7) via the collagenous binding motives (GPO) X and (GPP) X
Authors: Rajan Somasundaram, Martin Ruehl, Ines Schoenfelder, Richard Farndale, Graham Knight, Monika Schmid, Renate Ackermann, Martin Zeitz, Detlef Schuppan
Journal: Journal of Hepatology (2002)
Abdominal Dropsy.—Sixty-seven Tapping Operations on One Patient.
Authors: F. W. Thomas
Journal: JAMA (1893)

Marion, Ohio, Dec. 15, 1893. <h3>To the Editor:</h3> —The following interesting case is worthy of report, I think: Mrs. B., aged 80, from disturbed hepatic circulation has been afflicted with abdominal dropsy for the past eleven years. During the summer and fall of 1882 the abdominal cavity became so distended with the fluid that the lady was unable to walk, nor could she lie down, but was compelled to get what rest she could in an easy rocking chair. Drugs for carrying off fluids were tried with negative results. She finally consented to be tapped, and the operation was performed Dec. 23, 1882, for the first time. Great relief followed, and the patient was able to be up and around, but the fluid re-accumulated and she was again tapped seven weeks from the first operation. From that time until her death Dec. 3, 1893, she was tapped on an average
Left ventricular oxygen utilization efficiency is impaired in chronic streptozotocin-diabetic sheep
Authors: T Ramanathan
Journal: Cardiovascular Research (2002)

Objective: Energy metabolism is altered in the diabetic heart. However, direct in vivo evidence that diabetes impairs energetics at the chamber level is lacking. Therefore, we investigated the effect of diabetes on left ventricular (LV) energetics in a chronic ovine model. Methods: Diabetes was induced in Merino-cross sheep with streptozotocin. Experiments were performed in five animals following 12 months untreated diabetes and six animals served as controls. Open-chest anesthetized sheep were instrumented to determine the LV pressure–volume relationship, oxygen consumption and free fatty acid uptake. Results: Diabetes impaired LV contractility (1.5±0.5 vs. 2.3±0.5 mmHg/ml, P<0.01). Stroke work was preserved but stroke work efficiency (stroke work/pressure–volume area) deteriorated (52±4 vs. 58±3%, P<0.01). Plasma free fatty acid levels increased (1885±1078 vs. 354±203 mmol/l, P<0.01) as did LV free fatty acid uptake (312±278 vs. 90±47 μmol/beat per 100 g LV, P = 0.04). Contractile efficiency decreased (31.9±1.4 vs. 50.0±8.7%, P<0.01) while unloaded oxygen consumption did not change significantly. Therefore, LV oxygen utilization efficiency (stroke work/LV oxygen consumption) was compromised in the diabetic heart (14.9±2.8 vs. 24.3±4.0%, P<0.001). Conclusion: This is the first study to demonstrate that diabetes alters ventricular energetics in vivo. LV oxygen utilization efficiency is impaired as a consequence of decreased contractile efficiency and stroke work efficiency. Impaired efficiency of oxygen utilization may explain in part the increased sensitivity of the diabetic heart to ischemia and the accelerated deterioration of ventricular function in diabetic patients.
Evidence from US suggests that trials will not alter obstetric behaviour
Authors: J. Raisler
Journal: BMJ (1996)

Home births are currently rare and controversial in the United States. The most recent national figures show that in 1992 only 0.6% of infants were born at home.1 The attendants for these 25923 births were certified nurse-midwives (11.5%), physicians (18.1%), other midwives (31.9%), and others (38.5%). In many areas it is difficult or impossible to find a trained attendant for a home delivery, and hospital back up is almost non-existent. Mother and birth attendant often encounter suspicion and hostility if an obstetric problem necessitates transfer to hospital. Physicians and nursemidwives who attend home births may be denied malpractice coverage or have hospital admitting privileges revoked. …
BUPA and consultants over 70
Authors: D P Choyce
Journal: BMJ (1992)

notice.This would accommodate changes in personal or professional circumstances.Family health services authorities could match skills to jobs.Job sharing and mobility would be facilitated.The whole exercise may be construed as a global job share."Ghettoisation" for either sex would become voluntary rather than imposed by con- sumers.Family health services authorities' skill banks would offer a wider distribution of services and facilitate planning.Benefits would accrue to consumers and practitioners through a wider choice of service and variety of experience, re- spectively.
Nutrition: a medical, political, and public issue
Authors: P. L. White
Journal: JAMA (1979)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BISMUTH IN THE TREATMENT OF CONGENITAL SYPHILIS
Authors: CARROLL S. WRIGHT
Journal: JAMA (1927)

Since its introduction in the treatment of syphilis in 1921 by Sazerac and Leviditi, bismuth has been generally accepted as an antisyphilitic remedy of unquestionable merit. Laboratory experimentation and clinical trial have proved that bismuth is superior to mercury both therapeutically and from the standpoint of toxicity. It is only natural that a drug which has proved to be of such distinct value in acquired syphilis should be employed in congenital syphilis, that refractory offspring of the parent disease. It is strange, however, that the literature contains only scant reference to the value of bismuth in congenital syphilis. Among the first to report his experience with the use of bismuth in congenital syphilis was Müller,<sup>1</sup>who treated six cases in 1922 and found a good symptomatic response without toxic symptoms. In the following year Cajal and Spierer<sup>2</sup>reported the treatment of eight cases with a bismuth tartrate preparation,
A Twin Study of Human Obesity
Authors: Albert J. Stunkard
Journal: JAMA (1986)

Height, weight, and body mass index (BMI) were assessed in a sample of 1974 monozygotic and 2097 dizygotic male twin pairs. Concordance rates for different degrees of overweight were twice as high for monozygotic twins as for dizygotic twins. Classic twin methods estimated a high heritability for height, weight, and BMI, both at age 20 years (.80, .78, and .77, respectively) and at a 25-year follow-up (.80, .81, and .84, respectively). Height, weight, and BMI were highly correlated across time, and a path analysis suggested that the major part of that covariation was genetic. These results are similar to those of other twin studies of these measures and suggest that human fatness is under substantial genetic control.
Zur Frage des „Climacterium virile”
Authors: Heinrich Meng
Journal: Psychotherapy and Psychosomatics (1953)

Research Articles| January 20 2010 Zur Frage des "Climacterium virile" Subject Area: Psychiatry and Psychology Heinrich Meng Heinrich Meng Aus der Arbeitsgemeinschaft für Psychohygie¤e an der Universität Basel (Leitung: Prof. Dr.-med. Heinrich Meng) Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1953) 1 (2): 97–101. https://doi.org/10.1159/000278363 Article history Published Online: January 20 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Heinrich Meng; Zur Frage des "Climacterium virile". Acta Psychotherapeutica et Psychosomatica 1 February 1953; 1 (2): 97–101. https://doi.org/10.1159/000278363 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1953Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Regional wall motion improvement after coronary thrombolysis with recombinant tissue plasminogen activator: Importance of coronary angioplasty
Authors: Eric J. Topol, James L. Weiss, Jeffrey A. Brinker, Kenneth P. Brin, Sidney O. Gottlieb, Lewis C. Becker, Bernadine H. Bulkley, Nisha Chandra, John T. Flaherty, Gary Gerstenblith, Sheldon H. Gottlieb, Alan D. Guerci, Pamela Ouyang, Michaelene P. Llewellyn, Myron L. Weisfeldt, Edward P. Shapiro
Journal: Journal of the American College of Cardiology (1985)
PSYCHO-PHYSICS OF SLEEP—NATURAL AND INDUCED.
Authors: W. XAVIER SUDDUTH
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
So, farewell then, doctrine of double effect
Authors: C. Regnard, R. George, E. Grogan, T. Harlow, S. Hutchison, J. Keen, S. McGettrick, C. Manson, S. A. Murray, V. Robinson, P. Stone, C. Tallon
Journal: BMJ (2011)

Spence offers the cases for and against assisted suicide in a balanced way that is often lacking in such debates.1 He then raises the issue of double effect as a result of strong opioids. This is important because, if this effect exists, many doctors stand …
Comparison of Ampicillin and Tetracycline in Chronic Bronchitis
Authors: F. J. C. Millard, J. C. Batten
Journal: BMJ (1963)

Ampicillin (6[D(-) -a-aminophenylacetamido]penicil- lanic acid; " penbritin "), a new derivative of the penicillin nucleus, 6-aminopenicillanic acid, acts against many Gram-positive and Gram-negative organisms.In particular it has greater activity against Haemophilus influenzae than benzylpenicillin.Effective blood levels can be obtained after oral administration (Knudsen et al., 1961).These properties suggest that ampicillin may be valuable in the treatment of chronic bronchitis, and a trial was arranged to compare its efficacy with that of tetracycline. Material and MethodsThe trial took place from November, 1961, to April, 1962.The patients selected suffered from chronic bronchitis, which was defined as "the production of phlegm on most days for at least three months each year" (Fletcher et al., 1959).None of the patients suffered from any other respiratory disease, except for two who had mild bronchiectasis.Patients whose symptoms were predominantly due to asthma were excluded.The dose of both ampicillin and tetracycline was 500 mg.twice daily.Fifty-nine patients (48 men and 11 women) aged between 24 and 74 agreed to take part in the trial.Four patients did not attend for follow-up for social reasons, two died at home from unknown causes, and one devel- oped carcinoma of the stomach.Of the remaining 52, 22 were given ampicillin during the first three months' treatment followed by tetracycline during the second three months, and 30 were given tetracycline followed by ampicillin.There was no significant difference in the age, sex, smoking habits, or average peak flow of the two groups.The drugs were allocated by random selection ; they were prepared in identical capsules, the contents of the capsules being unknown to the physicians and patients.No other antibiotics were given during the trial, but expectorants, bronchodilators, and other treatment which might relieve the patients' symptoms were permitted.Patients attended monthly and their progress was assessed as follows:I.
New Seafood Safety Initiative
Authors: Stuart L. Nightingale
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dealing with residual bile duct stones.
Authors: R Mason
Journal: BMJ (1978)

Management of self-poisoned patients in hospital SIR,-Although we are in broad agreement with the conclusions of Dr R Gardner and his colleagues (18 November, p 1392) we would dispute the methods they adopted to assess success or failure in management.It has been clearly shown that psychiatrists show no uniformity in the management of this group of patients.1 Therefore it is not surprising that physicians proved to be as competent.We would also dispute that success in management can be assessed solely by a junior physician agreeing with the psychiatrist who has trained him over future management.Quite correctly Dr Gardner and his colleagues state that many self-poisoning patients "have taken tablets or medicines prescribed by medical practitioners."However, in a recent study of 236 patients suffering from overdoses in Newcastle upon Tyne we found that 2000 were receiving psychiatric treatment at the time of their overdose while a further 25 0 had at some time been under the care of a psychiatrist.This would not support the conclusion that better training in psychiatric assessment necessarily offers any advantage.We would suggest that from their data one has the right to conclude only that physicians are equally as incompetent as psychiatrists in assessing these patients and that perhaps we should look further to see if another professional discipline can help us.
LSD and Chromosome Damage
Authors: John Hoey
Journal: JAMA (1970)

To the Editor.—  The case report by Lillian Y. Hsu, MD, ( 211 :987,1970) was interesting and complete, but surprisingly misleading, especially to the lay public, who through the press are frequent readers of this and other journals.  I am certain that the authors did not wish to imply that LSD causes chromosomal aberrations, or congenital abnormalities. However, when I showed the article to a nonrandom selection of ten lay friends, nine interpreted the article as proving that LSD deforms children of users. One, a statistician, did not.  I do not object to the publication of such case reports. It astonishes me, however, that when a volatile subject such as LSD is involved, that no interpretative note of caution accompanied the article.  Specifically, to condemn the use of LSD, without valid evidence of harmful effects from use of the drug, will only increase the already broad credibility gap. Thus, if valid