Pseudothromboembolism in Myeloid Metaplasia
Authors: JAMES J. GORDON
Journal: Annals of Internal Medicine (1988)

Brief Reports1 June 1988Pseudothromboembolism in Myeloid MetaplasiaJAMES J. GORDON, M.D., MILTON AUSTIN, M.D., E. STEPHEN KURTIDES, M.D.JAMES J. GORDON, M.D.Search for more papers by this author, MILTON AUSTIN, M.D.Search for more papers by this author, E. STEPHEN KURTIDES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-6-837 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA patient with postpolycythemic myeloid metaplasia had recurrent pulmonary emboli despite adequate heparin therapy. At postmortem examination, the pulmonary thromboemboli were shown to be clusters of hematopoietic tissue, obstructing multiple branches of the pulmonary arterial tree. To our knowledge, this complication of myeloid metaplasia has not been reported previously.A 73-year-old white man with a history of polycythemia vera and severe aortic stenosis was admitted in February 1986 for aortic valve replacement. His polycythemia vera had been diagnosed at age 33 and managed with phlebotomy alone for 31 years. In 1983 he developed malaise, anorexia, and weight loss, secondary to...References1. WARDBLOCK HM. The natural history of agnogenic myeloid metaplasia (AMM) and a critical evaluation of its relationship with the myeloproliferative syndrome. Medicine (Baltimore). 1971;50(5):357-420. CrossrefMedlineGoogle Scholar2. KIELYSILVERSTEIN JM. Metastatic carcinoma stimulating agnogenic myeloid metaplasia and myelofibrosis. Cancer. 1969;24:1041-4. CrossrefMedlineGoogle Scholar3. ANDRESCHWARTZDAMESHEK JRW. Tuberculosis and myelosclerosis with myeloid metaplasia. JAMA. 1961;178:1169-74. CrossrefMedlineGoogle Scholar4. BREWSTERWIKKEBNAB HO. Myeloid metaplasia of the spleen with acute hemolytic anemia. N Engl J Med. 1942;227:822-5. CrossrefGoogle Scholar5. SILVERSTEIN M. Postpolycythemic myeloid metaplasia. Arch Intern Med. 1974;134:113-7. CrossrefMedlineGoogle Scholar6. SILVERSTEIN M. The evolution into and the treatment of late stage polycythemia vera. Semin Hematol. 1976;13(l):79-84. MedlineGoogle Scholar7. VIERASBOYDMORA FCP. Diffuse pulmonary uptake of indium-111 chloride in idiopathic myelofibrosis. Radiology. 1979;130:749-50. CrossrefMedlineGoogle Scholar8. HARNSBERGERDATZKNOCHELTAYLOR HFJA. Failure to detect extramedullary hematopoiesis during bone-marrow imaging with indium-111 or technetium-99m sulfur colloid. J Nucl Med. 1982;23:589-90. MedlineGoogle Scholar9. BRONNPAQUELETTETALMAN LJM. Intrathoracic extramedullary hematopoiesis: appearance on 99mTc sulfur colloid marrow scan. AJR. 1980;134:1254-5. CrossrefMedlineGoogle Scholar10. PATELKURTIDES NE. Ascites in agnogenic myeloid metaplasia: association with peritoneal implant of myeloid tissue and therapy. Cancer. 1982;50:1189-90. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES J. GORDON, M.D.; MILTON AUSTIN, M.D.; E. STEPHEN KURTIDES, M.D.Affiliations: Northwestern University Medical School Evanston, Illinois PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAlveolar Airspace and Pulmonary Artery Involvement by Extramedullary Hematopoiesis: A Unique Manifestation of MyelofibrosisCase 19-1995 1 June 1988Volume 108, Issue 6Page: 837-838KeywordsAortic valve replacementAutopsyHeparinHospital medicineInterleukinsPhlebotomyPolycythemia veraStenosisWeight loss ePublished: 1 December 2008 Issue Published: 1 June 1988 PDF downloadLoading ...