“Buffalo Humps” Associated with Protease Inhibitors
Authors: Raphael B. Stricker
Journal: Annals of Internal Medicine (1999)

Letters2 February 1999“Buffalo Humps” Associated with Protease InhibitorsJohn T. Schindler, MD, Katherine M. Spooner, MD, and Catherine F. Decker, MDJohn T. Schindler, MDNational Naval Medical Center; Bethesda, MD 20889Search for more papers by this author, Katherine M. Spooner, MDNational Naval Medical Center; Bethesda, MD 20889Search for more papers by this author, and Catherine F. Decker, MDNational Naval Medical Center; Bethesda, MD 20889Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-3-199902020-00034 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Although few reports have discussed the development of cervical neck masses in HIV-infected patients receiving only nucleoside analogues (1, 2), it was not until the recent addition of protease inhibitors to the antiretroviral regimen that “buffalo humps” and atypical fat redistribution became more evident to the clinician (3). It has been suggested, but not proven, that there is a relation between the use of these agents in combination with nucleoside and non-nucleoside analogues and the development of these body habitus changes.Stricker and Goldberg point out that there is probably a spectrum of body fat accumulation in HIV-infected ...References1. Lo JC, Mulligan K, Tai VW, Algren H, Schambelan M. “Buffalo hump” in men with HIV infection. Lancet. 1998;351:867-70. CrossrefMedlineGoogle Scholar2. Miller KK, Daly PA, Sentochnik D, Doweiko J, Samore M, Basgoz NO, et al . Pseudo-Cushing's syndrome in human immunodeficiency virus-infected patients. Clin Infect Dis. 1998;27:68-72. CrossrefMedlineGoogle Scholar3. Mann M, Piazza-Hepp T, Koller E, Gilbert C. Abnormal fat distribution in AIDS patients following protease inhibitor therapy: FDA summary [Abstract]. In: Program and Abstracts of the 5th Conference on Retrovirus and Opportunistic Infections. 1-5 February 1998, Chicago. Google Scholar4. Roth VR, Kravcik S, Angel JB. Development of cervical fat pads following therapy with human immunodeficiency virus type 1 protease inhibitors. Clin Infect Dis. 1998;27:65-7. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: John T. Schindler, MD; Katherine M. Spooner, MD; Catherine F. Decker, MDAffiliations: National Naval Medical Center; Bethesda, MD 20889 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee Also“Buffalo Humps” Associated with Protease Inhibitors John T. Schindler , Katherine M. Spooner , and Catherine F. Decker “Buffalo Humps” Associated with Protease Inhibitors Raphael B. Stricker and Billi Goldberg Metrics Cited byProtease Inhibitors and Prohormone ProcessingRaphael B. Stricker, MD and Billi Goldberg, MPAOral Thrush and HIV Protease Inhibitors 2 February 1999Volume 130, Issue 3Page: 242KeywordsAdipose tissueAntiretroviralsFatsHighly active antiretroviral therapyNucleosidesProtease inhibitor therapyProtease inhibitorsProteasesSteroidsWeight gain ePublished: 15 August 2000 Issue Published: 2 February 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...