tbuckley/cabot-search huggingface dataset:
Surveillance and Coordination Key to Reducing Foodborne Illness
Authors: B. M. Kuehn
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
INCREASED SEPTAL EXTRACELLULAR VOLUME ESTIMATED BY T1-MAPPING PREDICTS RIGHT ventricular PERFORMANCE IN PULMONARY HYPERTENSION
Authors: Eduardo Pozo, Ines Garcia-Lunar, Pablo Pazos, Claudia Calcagno, Sarayu Ramachandran, Charles Adapoe, Ajith Nair, Adam Jacobi, Valentin Fuster, Javier Sanz
Journal: Journal of the American College of Cardiology (2013)
Genetic manipulation of crops could offer healthier food, say scientists
Authors: G. Watts
Journal: BMJ (2012)

Genetic manipulation of crops may in the future produce plants able to manufacture fish oils, and grains that store zinc in those parts of the seed most favoured by consumers, scientists told a press briefing organised on Monday 12 March by the Science Media Centre in London.

Supermarkets and restaurants in the United Kingdom may continue to display signs and labels saying “GM free,” but plant scientists have not stopped developing the technology.

Questioned about the current state of public attitudes to genetic manipulation, Dale Sanders, director of the John Innes Centre, which conducts plant …
SERUM FIBRINOGEN IS MORE CLOSELY ASSOCIATED WITH LONGER-TERM ISCHEMIC CARDIAC EVENTS AFTER PERCUTANEOUS CORONARY INTERVENTION THAN VERIFYNOW P2Y12 PLATELET REACTIVITY MEASUREMENTS
Authors: Kelly Enright, Lawrence Ang, Shiqian Li, Phildrich Teh, Andrew Huynh, Mattheus Ramsis, Sahar Taqui, Samhita Palakodeti, Felice Lin, Mitul Patel, Ryan Reeves, Ehtisham Mahmud
Journal: Journal of the American College of Cardiology (2014)
The Delphi Procedure: Knowledge from Goat Viscera?
Authors: M. A. Rockwell
Journal: New England Journal of Medicine (1973)

Many important issues lie beyond the reach of rigorous scientific exploration. Man has continually searched for new, more powerful epistemologic tools in an effort to overcome the various ethical, technologic, economic and other barriers to application of conventional investigative procedures.The Delphi procedure is a relatively recent product of this search. This procedure seeks to supplement objective, scientific fact with subjective opinion. Delphi assumes that with experience comes useful intuitive knowledge. The procedure attempts to elicit this knowledge from a group of appropriately experienced persons, in a way that reduces individual biases and leads, so far as possible, to a . . .
Innovations in Data Collection, Management, and Archiving for Systematic Reviews
Authors: Tianjing Li, S. Swaroop Vedula, Nira Hadar, Christopher Parkin, Joseph Lau, Kay Dickersin
Journal: Annals of Internal Medicine (2015)

Data abstraction is a key step in conducting systematic reviews because data collected from study reports form the basis of appropriate conclusions. Recent methodological standards and expectations highlight several principles for data collection. To support implementation of these standards, this article provides a step-by-step tutorial for selecting data collection tools; constructing data collection forms; and abstracting, managing, and archiving data for systematic reviews. Examples are drawn from recent experience using the Systematic Review Data Repository for data collection and management. If it is done well, data collection for systematic reviews only needs to be done by 1 team and placed into a publicly accessible database for future use. Technological innovations, such as the Systematic Review Data Repository, will contribute to finding trustworthy answers for many health and health care questions.
CHRONOBIOLOGICAL PATTERNS OF ACUTE AORTIC DISSECTION IN MARFAN SYNDROME PATIENTS: DATA FROM THE INTERNATIONAL REGISTRY OF ACUTE AORTIC DISSECTION (IRAD)
Authors: Hasan Siddiqi, Mark Lindsay, Marco Di Eusanio, Stuart Hutchison, Alan Braverman, Mark Peterson, Thomas Gleason, Udo Sechtem, Truls Myrmel, Eduardo Bossone, Daniel Montgomery, Roberto Manfredini, Dan Gilon, Christoph Nienaber, Kim Eagle, Eric Isselbacher, Reed Pyeritz
Journal: Journal of the American College of Cardiology (2015)
My child's just knocked out a front tooth
Authors: A. S Blinkhorn, I. C Mackie
Journal: BMJ (1996)

Despite continuing improvements in oral health one in four children in Britain suffer some form of injury to their front teeth.1 Fortunately the clinical and technological advances made recently in dentistry will ensure that most of these children keep their smiles.

One type of dental trauma demands immediate action to ensure a successful result: when one or more adult teeth is knocked completely out of the mouth. If these teeth are put back into the appropriate socket there is a very good chance that they will be retained.2 Medical practitioners in accident and emergency departments or in general practice will often be the first point of contact for advice and care. They may be uncertain what to …
Treatment of Breast Abscesses with Penicillin
Authors: M. E. Florey, J. S. MacVine, M. A. M. Bigby
Journal: BMJ (1946)

The following account deals with various methods of treating breast abscesses with penicillin.The justification of those methods depended on their results as compared with those obtained from the methods at present employed.For this reason a series of controls was treated contemporaneously with Table Comtiparing Results in Breast Abscesses Duration in Days after First Treatment of No. of Pyrexia I Suppuration Healing Time Cases __I_ Mean±S.E.S.D
Effect of extracellular fluid volume expansion on maximum glucose reabsorption rate and glomerular tubular balance in single rat nephrons
Authors: Andrew D. Baines, John H. V. Bishop
Journal: Journal of Clinical Investigation (1971)

Extracellular fluid volume expansion with isotonic saline (7.5% of body weight) decreased maximum glucose reabsorption rate by rat kidneys at plasma glucose concentrations greater than 30 mM. Glucose reabsorption rate was 30.2 +/-1.6 (SE) mumoles/min.g kidney in nonexpanded rats; it was 18.4 +/-1.5 mumoles/min.g in volume-expanded rats. Glucose reabsorption determined by micropuncture was 92% complete at the end of accessible superficial proximal convolutions. Volume expansion resulted in a slight but statistically insignificant reduction of maximal glucose reabsorption rate in superficial nephrons from 786 +/-35 mumumoles/min.g kidney in nonexpanded rats to 720 +/-30 mumumoles/min.g in volume-expanded rats. Superficial nephron filtration rate was increased by volume expansion from 28.8 +/-1.2 nl/min.g to 36.6 +/-1.5 nl/min.g kidney. In nonexpanded rats, the ratio of glucose reabsorption to glomerular filtration (tmg/sgfr) was similar in superficial and juxtamedullary nephrons. In volume-expanded rats superficial nephron tmg/sgfr was greater than juxtamedullary nephron tmg/sgfr. Juxtamedullary nephron function was measured by puncturing loops of Henle in the exposed papillae of small rats. Volume expansion increased sgfr without much effect on tmg in superficial nephrons while it decreased tmg without much effect on sgfr in deep nephrons. Physical changes produced by volume expansion seem to exert their greatest effect on proximal tubular function in the inner cortex. The increase in heterogeneity of glomerular-tubular balance could account for increased splay of glucose titration curves previously reported to accompany volume expansion.
Mouse mammary tumor virus in anti-mitochondrial antibody producing mouse models
Authors: Guangzhi Zhang, Min Chen, Don Graham, Benchamas Subsin, Chelsea McDougall, Suzanna Gilady, Mark Kneteman, Lok Law, Mark Swain, Michael Trauner, Stephen Wrzesinski, Richard Flavell, Shawn Wasilenko, Andrew Mason
Journal: Journal of Hepatology (2011)
The Use of Medical Sociology on a Psychiatric Service: Research and Application
Authors: EMILY MUMFORD
Journal: American Journal of Psychiatry (1968)

Active exchange between theory, research, and application provides a rich environment for creative advances in sociology as well as in medicine. Medical sociology—a relatively new specialty within the social sciences—promises to contribute much to psychiatric research and practice. But the sociologist must learn to apply what he knows and to communicate with psychiatry without jargon. Both professions are cautioned against enthusiastic misapplication. Explaining the individual by describing his society is as misleading as explaining society by psychological mechanisms.
The Calculated Risk of Arthritis Treatment
Authors: JOSEPH LEE HOLLANDER
Journal: Annals of Internal Medicine (1965)

Editorial1 May 1965The Calculated Risk of Arthritis TreatmentJOSEPH LEE HOLLANDER, M.D., F.A.C.P.JOSEPH LEE HOLLANDER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1062 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the United States every year about 40,000 persons are killed by automobiles, and over a million are injured. Appalling as these statistics are, no one would suggest that auto travel should be abandoned, but we should drive more carefully.As new and more potent drugs are added to the medical armamentarium, the number of toxic effects from them also may appear so appalling that some are suggesting that all such agents, one by one, be abandoned for the good of mankind. Sincealldrugs that have been proved of use in the treatment of rheumatoid arthritis, including aspirin, have... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOSEPH LEE HOLLANDER, M.D., F.A.C.P.Affiliations: Arthritis Section Hospital of the University of Pennsylvania Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRisk Factors for Hydroxychloroquine and Chloroquine Retinopathy4-AminoquinolinesOphthalmologic safety of long-term hydroxychloroquine sulfate treatmentOphthalmologic safety of long-term hydroxychloroquine treatmentAdverse reactions in patients with rheumatic diseases. Retrospective analysis of causes of admission and out-patient attendance in a specialist centre.Reflections on possible mechanisms of action of anti-inflammatory drugsAn appraisal of chloroquineAntimalarial Treatment of Rheumatoid ArthritisOcular Lesions in Rheumatoid Arthritis and Related Disorders with Particular Reference to Retinopathy 1 May 1965Volume 62, Issue 5Page: 1062-1064KeywordsArthritisAspirinDrugsRheumatoid arthritis ePublished: 1 December 2008 Issue Published: 1 May 1965 PDF downloadLoading ...
Landmark perspective: Closed-chest massage, Kouwenhoven, Jude, Knickerbocker
Authors: A. Sladen
Journal: JAMA (1984)

Annually in the United States, approximately 1 1/2 million persons suffer a myocardial infarction.<sup>1</sup>Of these, about 660,000 die. Approximately 60% of these deaths from acute myocardial infarction occur outside the hospital and, in the majority of cases, within the first two hours of the onset of symptoms.<sup>1</sup>In fact, in 25% there are no premonitory signs and death is the first manifestation of coronary artery disease. The primary mechanisms of sudden death are ventricular fibrillation in 62%, ventricular tachycardia in 7%, and severe bradydysrhythmias and asystole in 31%. If there were an easily available technique that could be applied immediately after the onset of "clinical" death and rapidly followed with electrical or chemical therapy or both, it has been estimated that 200,000 to 300,000 persons could be saved annually in the United States alone. The manuscript entitled "Closed-Chest Cardiac Massage" by W. B. Kouwenhoven, James R. Jude,
Abstract A27: Comprehensive analysis of the TMPRSS2-ERG translocation during prostate cancer progression
Authors: Shyh-Han Tan, I. Sesterhenn, S. Srivastava, L. Bubendorf, C. Ruiz, M. Braun, V.J. Scheble, T. Zellweger, C.A. Rentsch, A. Bachmann, Albert Dobi, S. Perner
Journal: Cancer Research (2012)

Abstract Introduction: Approximately half of the diagnosed prostate carcinomas (PC) are characterized by a chromosomal rearrangement fusing the androgen regulated gene TMPRSS2 to the oncogenic ETS transcription factor ERG. Aim of this study was to comprehensively analyze the impact of this translocation on the expression of the ERG gene in hormone-naïve (untreated) and castration-resistant prostate cancers and to define the influence of AR protein expression and genomic amplification in this context. Methods: We constructed a tissue microarray (TMA) containing 915 tissue cores from 107 hormone-naïve PC and from 101 castration-resistant (CR) PC. In addition, we included 56 specimens from distant metastases. We analyzed the TMPRSS2-ERG translocation status by fluorescence in-situ hybridization and the expression profiles of ERG, AR and the proliferation marker Ki67 by immunohistochemistry. Results: Nearly half of the analyzed PC tissue specimens (untreated: 38%, castration-resistant: 46%) harbored a TMPRSS2-ERG gene fusion. Untreated PC with positive translocation status showed increased tumor cell proliferation (p &amp;lt; 0.05). As expected, TMPRSS2-ERG gene fusion was strongly associated with increased ERG protein expression in untreated, as well as in castration-resistant PC (both p &amp;lt; 0.0001). However, we detected a subgroup (26%) of CR PCs with the gene fusion, but without detectable ERG protein expression. This subgroup showed significantly lower levels of AR protein expression and of the androgen regulated serum PSA (both p&amp;gt;0.05). Conclusions: This comprehensive study comparing the TMPRSS2-ERG gene and ERG protein expression status in a large cohort of hormone-naïve and CR PC, identifies a subgroup of translocated CR PCs without ERG protein expression. Our results suggest that this subgroup may represent CR PCs with a dispensed AR pathway. Further analyses may help to explain if these tumors represent a distinct subgroup of AR independent CR PCs. Citation Format: Shyh-Han Tan, I. Sesterhenn, S. Srivastava, L. Bubendorf, C. Ruiz, M. Braun, V.J. Scheble, T. Zellweger, C.A. Rentsch, A. Bachmann, Albert Dobi, S. Perner. Comprehensive analysis of the TMPRSS2-ERG translocation during prostate cancer progression [abstract]. In: Proceedings of the AACR Special Conference on Advances in Prostate Cancer Research; 2012 Feb 6-9; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2012;72(4 Suppl):Abstract nr A27.
The transmembrane protein meckelin (MKS3) is mutated in Meckel-Gruber syndrome and the wpk rat
Authors: Ursula M Smith, Mark Consugar, Louise J Tee, Brandy M McKee, Esther N Maina, Shelly Whelan, Neil V Morgan, Erin Goranson, Paul Gissen, Stacie Lilliquist, Irene A Aligianis, Christopher J Ward, Shanaz Pasha, Rachaneekorn Punyashthiti, Saghira Malik Sharif, Philip A Batman, Christopher P Bennett, C Geoffrey Woods, Carole McKeown, Martine Bucourt, Caroline A Miller, Phillip Cox, Lihadh AlGazali, Richard C Trembath, Vicente E Torres, Tania Attie-Bitach, Deirdre A Kelly, Eamonn R Maher, Vincent H Gattone, Peter C Harris, Colin A Johnson
Journal: Nature Genetics (2006)
Cyclophosphamide in combination with tumor lysate and TLR9 ligand regresses murine neuroblastoma
Authors: Jill Gershan, Kristen Barr, James Weber, Bryon Johnson
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Neuroblastoma is a pediatric cancer of neural crest origin that accounts for 12% of all pediatric cancer deaths. Despite improved survival in patients that receive standard care plus anti-GD2 immune therapy, there remains a 40% mortality rate in high-risk patients. This high
British trial of transmyocardial revascularisation is continuing
Authors: N. Caine, P. M Schofield, J. Wallwork, L. D Sharples
Journal: BMJ (1998)

Editor—Josefson reported the decision by the US Food and Drug Administration's advisory committee not to support approval of the transmyocardial revascularisation heart laser system (PLC Systems).1 2 We are writing to reinforce the need to support the British randomised controlled trial of this and similar technologies. Unlike the American study, the British trial, funded by the Medical Research Council, does not allow crossover from medical to surgical treatment. The trial is being conducted with meticulous attention to good scientific practice, and …
The Pseudomonas aeruginosa exotoxin A translocation domain facilitates the routing of CPP–protein cargos to the cytosol of eukaryotic cells
Authors: Arshiya F. Mohammed, Aws Abdul-Wahid, Eric H.-B. Huang, Eleonora Bolewska-Pedyczak, Marzena Cydzik, Amaalia E. Broad, Jean Gariépy
Journal: Journal of Controlled Release (2012)
21 10-YEARS PROGNOSTIC VALUE OF FIBROTEST AND STEATOTEST FOR LIVER-RELATED AND CARDIOVASCULAR DEATH IN PATIENTS WITH TYPE-2 DIABETES AND/OR HYPERLIPIDEMIA
Authors: H. Perazzo, M. Munteanu, Y. Ngo, F. Huet, M. Couteau, P. Lebray, S. Jacqueminet, F. Imbert-Bismut, V. Ratziu, A. Hartemann-Heurtier, P. Giral, T. Poynard
Journal: Journal of Hepatology (2013)
High-dose paracetamol in stroke: new trials are necessary and feasible
Authors: Heleen M den Hertog, H Bart van der Worp, H Maarten A van Gemert, Ale Algra, L Jaap Kappelle, Jan van Gijn, Peter J Koudstaal, Diederik WJ Dippel
Journal: The Lancet Neurology (2009)
Does This Patient Have Appendicitis?-Reply
Authors: James Wagner
Journal: JAMA (1997)

In Reply.  —Dr Schneider takes issue with our finding that anorexia has little impact on the diagnosis of appendicitis, which was based on the likelihood ratio of 1.27. In his practice, Schneider has noted how uncommon it is for patients with acute appendicitis to report that they are hungry. This observation attests to the sensitivity of anorexia, which we calculated at 68%. Indeed, anorexia is the third most sensitive sign or symptom of the 13 we evaluated. However, physicians do not accept this level of sensitivity for ruling out any disease, and we cannot explain the discrepancy between the data we analyzed and Schneider's experience.  Drs Moustafa and Newton raise an important ethical question: Is the test for rebound tenderness humane or even necessary? Based on the power of the test disclosed by our review, we would have to conclude that performing the test for rebound tenderness once is indeed necessary. However,
Use and Abuse of Medicine
Authors: Walter G. Gunn
Journal: JAMA (1983)

Growing criticism of medical care from certain scholarly quarters became somewhat more intense in the last decade, and the word "medicalization" was coined to imply that medicine had spread too broadly into areas that do not concern it. Medicine, the critics feared, had invaded community life and was now influencing both health care policymakers and the citizenry. Was this criticism valid or overstated? In this thoughtful, well-edited volume, clinicians, historians, and anthropologists attempt to answer this question using case studies from their own disciplines. The results are mixed. A goodly amount of the anthropological material describes health care commingled with community life in primitive and traditional nonwestern societies. Such integration seems to show positive results. As an example of this beneficial union of medicine and the society it serves, an in-depth study of couvade (the experience of pregnancy-related symptoms by the mates of expectant women) is presented. This and other
Integrity of Energy Stores in Cat Papillary Muscle
Authors: PETER E. POOL, BRIAN M. CHANDLER, EDMUND H. SONNENBLICK, EUGENE BRAUNWALD
Journal: Circulation Research (1968)

Although isolated cat papillary muscles have proved useful in a variety of physiologic and pharmacologic studies, the energy integrity of this preparation has been questioned. Accordingly, papillary muscles (avg diam = 1.3 mm) were either placed in oxygenated Krebs solution for 1 hour at 26°C at rest or were made to contract at various frequencies and temperatures and for various durations. In addition, samples of right ventricular muscle were obtained from living cats. Specimens were frozen in liquid nitrogen-cooled isopentane for determination of ATP and creatine phosphate (CP). In vivo CP + ATP of right ventricular muscle was 12.9±0.8 µmoles/g. In papillary muscles at rest, CP + ATP was 16.7±0.6 µmoles/g, significantly higher than right ventricular muscle in vivo ( P &lt;.01). In vitro at 12 contractions/minute, CP + ATP was 16.0±1.0 µmoles/g, not different from resting papillary muscles but higher than in vivo stores in right ventricular muscle. At 30 or 60 contractions/minute, CP + ATP was reduced to 13.7±1.1 and 11.1±0.7 µmole/g. Neither increasing the in vitro temperature from 26° to 37°C, nor extending the duration of stimulation from 1 to 3 hours at 12/minute significantly altered CP + ATP. It is concluded that the energy stores in papillary muscles, even of moderately large diameter, are intact for at least 3 hours while contracting at frequencies of 12/minute at 26°C. Further, energy stores of papillary muscle are even greater than those found in right ventricular muscle in vivo. While muscle is contracting at 30 or 60/minute, its energy stores may be slightly limited.
Novel human coronavirus associated with respiratory disease
Authors: Kath Senior
Journal: The Lancet Infectious Diseases (2005)

Jeffrey S Kahn and colleagues at Yale University School of Medicine have identified a novel human coronavirus in children in New Haven, CT, USA, that may be the cause of previously unattributed respiratory tract infections (J Infect Dis 2005; 191: 492–98). The same virus has been detected in children with Kawasaki disease. "Further studies are required to determine the precise role played by New Haven coronavirus in the pathogenesis of Kawasaki disease, and to investigate whether the virus is linked with other clinical syndromes", comments Kahn.
Is Weight Loss Beneficial for Reduction of Morbidity and Mortality?
Authors: Peter M. Nilsson
Journal: Diabetes Care (2008)

The increase of obesity and type 2 diabetes on a global scale has increased the interest in how to counteract this epidemic. Improved lifestyle in general is a fundamental approach, but other remedies such as specific weight reduction or diabetes preventive drugs and surgery have also been tested. One problem to understand is what really happens after weight loss. Ongoing studies will try to address this question, such as the Swedish Obese Subjects (SOS) surgery study, the Look AHEAD (Action for Health in Diabetes) trial in the U.S. (recruiting obese type 2 diabetic patients), and the Comprehensive Rimonabant Evaluation Study of Cardiovascular End Points and Outcomes (CRESCENDO) trial (by use of rimonabant versus placebo). This is very important, since previously, several observational studies in large population-based cohorts have indicated some detrimental effects of weight loss, even after intentional weight loss, with increased morbidity and mortality rates.