Abnormal Carbohydrate Metabolism in Renal Disease
Authors: BURTON D. COHEN
Journal: Annals of Internal Medicine (1962)

Article1 August 1962Abnormal Carbohydrate Metabolism in Renal DiseaseBlood Glucose Unresponsiveness to Hypoglycemia, Epinephrine, and GlucagonBURTON D. COHEN, M.D.BURTON D. COHEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-2-204 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSeveral disease states share with diabetes mellitus a decreased rate of decline of blood glucose manifested by an elevated fasting blood sugar and an abnormal glucose tolerance. These include hepatic cirrhosis (1), malignancy (2, 3), eclampsia (4, 5), renal disease (6, 7), essential hyperlipemia (8), and a variety of endocrine disorders such as Cushing's syndrome, acromegaly, thyrotoxicosis, and pheochromocytoma (9). This paper attempts to define the site of this metabolic defect in patients with renal disease.In 1916 Myers and co-workers (10, 11) observed fasting hyperglycemia in 20 per cent of patients with renal disease. This finding, subsequently confirmed by...References1. HILLMAN RW: Dextrose, insulin and epinephrine tolerance in cirrhosis of the liver. Amer. J. Dig. Dis. 16: 174, 1949. CrossrefMedlineGoogle Scholar2. ROHDENBURGBERNHARDKREHBIEL GLAO: Sugar tolerance in cancer. J. A. M. A. 72: 1528, 1919. CrossrefGoogle Scholar3. WOODWARDFRY GEEG: The hyperglycemia of cancer. Biochem. J. 26: 889, 1932. CrossrefMedlineGoogle Scholar4. STANDERHARRISON HJEP: Carbohydrate metabolism in eclampsia. Amer. J. Obstet. Gynec. 18: 17, 1929. CrossrefGoogle Scholar5. BURT RL: Peripheral utilization of glucose in pregnancy. II. Pre-eclampsia. Obstet. Gynec. (N. Y.) 6: 51, 1955. Google Scholar6. 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RUNYANHURWITZROBBINS JWDSL: Effect of Kimmelstiel-Wilson syndrome on insulin requirements in diabetes. New Engl. J. Med. 252: 388, 1955. CrossrefMedlineGoogle Scholar43. WILSONROOTMARBLE JLHFA: Diabetic nephropathy, a clinical syndrome. Ibid. 245: 513, 1951. Google Scholar44. HATCHPARRISH FEAE: Apparent remission of a severe diabetic on developing the Kimmelstiel-Wilson syndrome. Ann. Intern. Med. 54: 544, 1961. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Medical Research Service, Veterans Administration Hospital, and the Department of Medicine, Cornell University Medical College, New York, New York.Dr. Cohen is a clinical investigator of the Veterans Administration.Requests for reprints should be addressed to Burton D. Cohen, M.D., The Bronx Hospital, 1276 Fulton Avenue, Bronx 56, New York.*This term should not be confused with "renal glycosuria" which results from a decreased renal threshold for glucose absorption. 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LEBOVITZ, M.D.Untersuchungen zur urämischen KohlenhydratstoffwechselstörungDie NiereninsuffizienzNiere bei EndokrinopathienThe effect of uremic serum on carbohydrate metabolism in rat diaphragmHyperglycemia and Hyperosmolality Complicating Peritoneal DialysisJAMES BOYER, M.D., GORDON N. GILL, M.D., FRANKLIN H. EPSTEIN, M.D.The effect of potassium on the imparired glucose tolerance in chronic uremiaAzotemia and Glucose IntoleranceJAMES M. CERLETTY, M.D., NORMAN H. ENGBRING, M.D.ROLE OF INSULIN IN GLUCOSE INTOLERANCE IN URÆMIAGlucose Intolerance in Patients on Long-term Intermittent DialysisROGER H. HUTCHINGS, M.D., ROBERT M. HEGSTROM, M.D., BELDING H. SCRIBNER, M.D.The Study of Carbohydrate MetabolismEtude de la glycor�gulation dans l'insuffisance r�nale chronique 1Abnormal carbohydrate metabolism in renal failureInsulin inhibition and antagonismManagement of chronic renal failureConsiderations in the patient with diminished renal functionUntersuchungen zum Kohlenhydratstoffwechsel bei Niereninsuffizienz 1 August 1962Volume 57, Issue 2_Part_1Page: 204-213KeywordsGlucagonGlucoseHospital medicineHyperglycemiaHyperlipidemiaHypoglycemiaInsulinInsulin signalingPheochromocytomaRenal diseases Issue Published: 1 August 1962 PDF DownloadLoading ...