Prophylactic Granulocytes in the Neutropenic Host
Authors: LOWELL S. YOUNG
Journal: Annals of Internal Medicine (1982)

Editorials1 February 1982Prophylactic Granulocytes in the Neutropenic HostLOWELL S. YOUNG, M.D.LOWELL S. YOUNG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-2-240 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOne of the more sobering realities of clinical investigation is that some innovations that initially appear to be major advances later prove to be of more limited value or become identified with major hazards. This appears to be the case with granulocyte transfusions, a costly form of intervention whose therapeutic and prophylactic benefit to neutropenic patients seemed to have been established by an initial series of controlled clinical trials (1, 2). Earlier enthusiastic reports, however, did not mention the complications of transfusion-associated viral infections. This is an area now being carefully reassessed.In this issue, Hersman and colleagues (3) have...References1. HERZIGHERZIGGRAW RGR. Successful granulocyte transfusion therapy for gram-negative septicemia. N Engl J Med. 1977;296:701-5. CrossrefMedlineGoogle Scholar2. CLIFTSANDERSTHOMAS RJE. Granulocyte transfusions for the prevention of infection in patients receiving bone marrow transplants. N Engl J Med. 1978;298:1052-7. CrossrefMedlineGoogle Scholar3. HERSMANMEYERSTHOMASBUCKNER JJEC. The effect of granulocyte transfusions on the incidence of cytomegalovirus infection after allogeneic marrow transplantation. Ann Intern Med. 1982; 96:149-52. LinkGoogle Scholar4. WINSTONHOYOUNGGALE DWLR. Prophylactic granulocyte transfusions during human bone marrow transplantation. Am J Med. 1981;68:893-7. CrossrefGoogle Scholar5. MEYERSSPENCERWATTS JHJ. Cytomegalovirus pneumonia after human marrow transplantation. Ann Intern Med. 1975;82:181-8. LinkGoogle Scholar6. LANGHANSHAW DJ. Cytomegalovirus and the post perfusion syndrome. Recognition of primary infection in four cases. N Engl J Med. 1969;280:1145-9. CrossrefMedlineGoogle Scholar7. HENLEHENLESCRIBA WGM. Antibody responses to the Epstein-Barr virus and cytomegaloviruses after open heart and other surgery. N Engl J Med. 1970;282:1068-74. CrossrefMedlineGoogle Scholar8. LANGEBERTRODGERSBOGGESSRIXSE DPBHR. Reduction of post perfusion cytomegalovirus infections following the use of leukocyte depleted blood. Transjusion. 1977;17:391-5. CrossrefMedlineGoogle Scholar9. TOLKOFF-RUBINRUBINKELLERBAKERSTEWARDHIRSCH NREGJM. Cytomegalovirus infection in dialysis patients and personnel. Ann Intern Med. 1978;89:625-8. LinkGoogle Scholar10. HARNDENELSDALEYOUNGROSS DTDA. The isolation of cytomegalovirus from peripheral blood. Blood. 1967;30:120-5. CrossrefMedlineGoogle Scholar11. CHEUNGLANG KD. Transmission and activation of cytomegalovirus with blood transfusion: a mouse model. J Infect Dis. 1977;135:841-5. CrossrefMedlineGoogle Scholar12. WRIGHTROBICHAUDPIZZODEISSEROTH DKPA. Lethal pulmonary reactions associated with combined use of amphotericin B and leukocyte transfusion. N Engl J Med. 1981;304:1185-9. CrossrefMedlineGoogle Scholar13. SCHIFFERAISNERDALYSCHIMPFFWIERNIK CJPSP. Alloimmunization following prophylactic granulocyte transfusion. Blood. 1979;54:766-74. CrossrefMedlineGoogle Scholar14. STRAUSSCONNETTGALE RJR. A controlled trial of prophylactic granulocyte transfusions during initial induction chemotherapy for acute myelogenous leukemia. N Engl J Med. 1981;305:597-603. CrossrefMedlineGoogle Scholar15. LOVESCHIMPFFSCHIFFERWIERNIK LSCP. Improved prognosis for granulocytopenic patients with gram negative rod bacteremia. Am J Med. 1980;68:643-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Infectious Diseases Department of Medicine University of California Los Angeles, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMyeloid progenitors protect against invasive aspergillosis andPseudomonas aeruginosa infection following hematopoietic stem cell transplantationGranulocyte transfusions: from neutrophil replacement to immunereconstitutionNeonatal Sepsis: The Potential for ImmunotherapyThe New Fluorinated Quinolones for Infection Prevention in Acute LeukemiaLOWELL S. YOUNG, M.D.Production of Hematopoietic Cells in CultureInfections in Children with Malignant DiseaseAnti-LPS antibody response in pseudomonas aeruginosa infectionsThe Immune Compromised HostNosocomial Infections in Compromised Hosts 1 February 1982Volume 96, Issue 2Page: 240-242KeywordsClinical trialsGranulocytes Issue Published: 1 February 1982 PDF DownloadLoading ...