tbuckley/cabot-search huggingface dataset:
Scleredema diabeticorum of Buschke confined to the thighs
Authors: A. M. FARRELL, A.C. BRANFOOT, J. MOSS, L. PAPADAKI, D.F. WOODROW, C.B. BUNKER
Journal: British Journal of Dermatology (1996)

We describe a patient with insulin-dependent diabetes without vascular complications in whom scleredema was confined to the thighs. Electron microscopy demonstrated heterogeneity in both the size and density of the collagen fibrils and the presence of filamentous material between them.
Correction: American Cutaneous Leishmaniasis in U.S. Travelers
Authors: Barbara L. Herwaldt
Journal: Annals of Internal Medicine (1993)

Corrections15 July 1993Correction: American Cutaneous Leishmaniasis in U.S. TravelersFREEBarbara L. Herwaldt, MD, Susan L. Stokes, MD, and Dennis D. Juranek, MDBarbara L. Herwaldt, MDSearch for more papers by this author, Susan L. Stokes, MDSearch for more papers by this author, and Dennis D. Juranek, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-2-199307150-00031 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The abstract conclusion and the precis on the table of contents contained errors introduced during the editorial process regarding the geographic areas in which U.S. travelers have acquired American cutaneous leishmaniasis. The abstract conclusion should not have included the state of Texas and should have read as follows:Travelers to forested areas in Mexico and Central and South America and their physicians need to be educated about the risk for acquiring leishmaniasis even during short stays, as well as about effective preventive measures and appropriate medical management.REFERENCE1. Herwaldt BL, Stokes SL, Juranek DD. American cutaneous leishmaniasis in U.S. travelers. Ann Intern Med. 1993; 118:779-84. Google Scholar Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 July 1993Volume 119, Issue 2Page: 173KeywordsGeographic areasLeishmaniasis ePublished: 15 August 2000 Issue Published: 15 July 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Outcome of patients activating an unrelated donor search for severe acquired aplastic anemia
Authors: Sébastien Maury, Marie‐Lorraine Balère‐Appert, Simona Pollichieni, Rosi Oneto, Ibrahim Yakoub‐Agha, Franco Locatelli, Jean‐Hugues Dalle, Edoardo Lanino, Alain Fischer, Andrea Pession, Anne Huynh, Walter Barberi, Mohamad Mohty, Antonio Risitano, Noel Milpied, Gérard Socié, Andrea Bacigalupo, Judith Marsh, Jakob R. Passweg
Journal: American Journal of Hematology (2013)

Patients with severe aplastic anemia (SAA) without a sibling donor receive immunosuppressive treatment (IST) with anti-thymocyte globulin (ATG). In the case of no response to IST, a voluntary unrelated donor (VUD) search is usually started. This study analyzes the outcome of ATG-refractory SAA patients activating a VUD search. Of 179 patients, 68 had at least one HLA-A, -B, and -DR matched donor identified and underwent HSCT while 50 also with a donor were not transplanted because of early death (8), late response to IST (34), transplant refusal (1), or other (7). Conversely, 61 had no matched donor, 13 of those ultimately received a mismatched HSCT. All but one received marrow stem cells. Among patients aged <17 years, those with at least one matched donor had a significant higher 4-year survival as compared to others (79% ± 6% versus 53% ± 10%, P = 0.01). There was also a survival advantage independent of recipient age when the donor search was initiated in the recent 2000-2005 study-period (74% ± 6% versus 47% ± 10%, P < 0.05). In multivariate analysis, the identification of a matched VUD tended to impact favourably on survival in patients with a recent donor search (P = 0.07). This study provides evidence for the use of unrelated donor HSCT in children and adults with IST-refractory SAA.
Diabetes: going downhill fast!
Authors: Neil McQuoid
Journal: British Journal of Sports Medicine (1997)

<h3>Background</h3> Lung clearance index (LCI) measured by multiple breath washout (MBW) is a sensitive indicator of early lung disease in Cystic Fibrosis (CF).<sup>1</sup> MBW using sulphur hexafluoride (SF<sub>6</sub>) and mass spectrometry (MS) is currently the gold standard, but equipment is limited to a few centres. Although commercial devices based on SF<sub>6</sub> have been developed, use of SF<sub>6</sub> is expensive and restricted in some countries. Commercial devices using nitrogen (N<sub>2</sub>), which is cheaper and widely available, have been developed recently to increase accessibility of this test in research and clinical practice but have yet to be validated in children. The aim of this study was to compare values of LCI and Functional Residual Capacity (FRC) in children using the N<sub>2-</sub>MBW EasyOne Pro® LAB system (ndd Medical Technologies) and the MS (AMIS 2000, Innovision ApS). <h3>Methods</h3> School-age children with CF and healthy controls completed MBW in triplicate on both the EasyOne Pro® and MS in random order on the same occasion. Within-subject agreement between devices for LCI and FRC was assessed by Bland-Altman analysis. <h3>Results</h3> Of the 50 children recruited, all completed testing using MS, while 5 failed quality control on the EasyOne Pro® LAB. Paired results from both devices were obtained in 26 children with CF (mean age [range]) (13.3y[7.8y-17.4y]) and 19 controls (14.8y [12.5y-16.7y]). LCI was significantly higher in those with CF when using both devices (mean difference[95% CI], CF-controls): 2.47[1.4;3.5] for the MS-SF<sub>6</sub> and 2.20[1.2–3.2] for N<sub>2</sub>-MBW. There were no significant group differences between devices for either LCI (mean difference[95% CI]) -0.14[-0.45;0.16] or FRC -0.15L[-0.2;-0.08]. Within-subject variability was proportional to mean values (see Figure) and ranged from 0.4–15.7% for LCI and 0.0–19.6% for FRC. <h3>Conclusion</h3> Despite some previous reports that N<sub>2-</sub>washout results in higher LCI values than MS-SF<sub>6 </sub>washout, on average, we found similar values in both healthy school-age children and those with CF. Further work is required to examine causes of within-subject variability and assess validity and sensitivity over a wider age range, including preschool children, before commercial N<sub>2</sub>-MBW devices can be confidently used in multi-centre trials. <h3>Reference</h3> Aurora <i>et al</i>. <i>Am J Respir Crit Care Med. </i>2011;183:752–8
A Unique Case of a 7-Year-Old With Noonan's Syndrome, Hypertrophic Cardiomyopathy, Biventricular Outflow Tract Obstruction, and a Right Ventricular Aneurysm
Authors: Robert J. Tozzi, Ahmed M. Abdel-Razek, George Kipel, Julius M. Gardin
Journal: Journal of the American College of Cardiology (2013)
Infection of the Retina by Human Immunodeficiency Virus Type I
Authors: R J Pomerantz, D R Kuritzkes, S M de la Monte, T R Rota, A S Baker, D Albert, D H Bor, E L Feldman, R T Schooley, M S Hirsch
Journal: New England Journal of Medicine (1987)

HUMAN immunodeficiency virus (HIV) is the etiologic agent of the acquired immunodeficiency syndrome (AIDS).1 2 3 4 HIV penetrates specific cells bearing the CD4 surface antigen5 , 6 and has been observed in helper T lymphocytes, monocytes, Langerhans' cells, and recently, astrocytes, endothelial cells, oligodendrocytes, and neurons.7 8 9 10 11 HIV-infected cells have been found in the blood, semen, vaginal secretions, breast milk, lymph nodes, brain, spinal cord, and peripheral nerves.7 8 9 10 11 12 13 14 15 16 17 18 19 Many patients with HIV infection have a variety of ocular abnormalities not associated with obvious opportunistic infections; these abnormalities include cotton-wool spots and microvascular changes of the retina.20 21 22 23 24 25 26 27 These observations, together with the established neurotropism of HIV, . . .
Will the Circle Be Unbroken?
Authors: William E. Golden
Journal: JAMA (1980)

Looking out of hospital windows at the urban sprawl containing acres of ruined and debilitated communities, it is difficult not to consider the ultimate futility of some of the more successful hospital discharges. Physicians can suture wounds, reduce suffering, and cure infections, but are hard pressed to alleviate the human condition of the patient's social milieu. Coulter's article in this issue ofThe Journal(p 1207) poignantly underscores the lonely battles some patients fight once outside of the clinics and wards. The medical care that salvaged an epileptic patient's life was no match for the social forces that magnified the subsequent morbidity until it became a mortality. Physicians, unfortunately, have no wonder drug for the tragedy of stigma and the heartbreak of isolation. The patient's suicide in Coulter's COMMENTARY represents a tragic finality of a life not uncommon to individuals with permanent disability. Family neglect and official indifference are all
Histopathology and medical laboratory scientific officers Pathologists are responsible for diagnosis
Authors: D H Wright, R Y Ball, J D Biggart, D C Allen, T J Jones, L Harvey, D Slater, R I Harris, C F Loughran
Journal: BMJ (1994)

<h3>Objective</h3> The aim of the study was to assess the predictive value and clinical significance of the sense of coherence (SOC) in the assessment of work ability in psychiatric patients with prolonged and complicated disability. SOC is a strong determinant of positive health and successful coping. <h3>Methods</h3> Our cohort consists of 100 consecutive and consented patients whose work ability was assessed at the Outpatient Psychiatric Unit of the Helsinki University Hospital in 2010–2011. SOC was measured by Antonovsky’s model using a short questionnaire SOC-13. After one year follow-up altogether 90 patients were reached for a phone interview. We studied how SOC associated with the diagnostic group and other functional measurements (such as Sheehan Disability Scale [SDS], Return to work Self Efficacy [RTW-SE] and Social and Occupational Functioning Assessment Scale [SOFAS]), and how SOC predicts return to work. <h3>Results</h3> Patients with mood disorders (65%) showed the lowest (mean 45.9) and psychotic patients (6%) showed the highest SOC scores (mean 62.5), (p &lt; 0.0005). SOC correlated with baseline RTW-SE (B = 0.715 and p &lt; 0.0005), SDS (B = −0.076 and p &lt; 0.0005 the scale being inverted) and SOFAS (B = 0.193 and p = 0.005). 28% of the patients had returned to competitive and 69% to any kind of working life activities as 31% were disable to work. SOC did not predict the return to competitive employment (B = 0.0024 and p = 0.124) but predicted the return to any working life activity (B = 0.056 and p = 0.002). <h3>Conclusions </h3> SOC predicted work ability after one year of follow-up independent of psychiatric illness and was associated with common psychiatric functional measurements (SDS, RTW-SE, SOFAS). Psychological resources are worth measuring and focusing on in return to work practices.
Dynamic regulation of macrophage polarization via coupled multicellular networks
Authors: Yishan Chuang, Joshua N Leonard
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Macrophages functionally polarize towards either immunostimulatory (M1) or immunosuppressive (M2) phenotypes, and tumor-associated macrophages (TAMs) exhibit an M2-like phenotype that impedes immunotherapy. Although the importance of M2 cells in tumor progression is well
John Archibald Easton
Authors: Graham Easton, Eric Brown
Journal: BMJ (2004)

Former consultant haematologist Wexham Park Hospital, Slough (b London 1930; q St Thomas' Hospital, London, 1956; FRCPath, DPath), died from metastatic renal cancer on 1 November 2004.​2004.




Figure 1




Before medical school, John did his national service in the Royal Army Medical Corps. Following a spell in general practice, he took up pathology after some careers advice from the then editor of the Lancet, Theodore Fox. He began his consultant post just as Wexham Park Hospital opened, and in the early years covered haematology, bacteriology and biochemistry for all three of the Windsor group of hospitals. Later he specialised, taking on responsibility for haematology throughout East Berkshire, with a particular interest in childhood leukaemia and haemophilia. In retirement John enjoyed fly fishing and travel. He leaves a wife, Sue; three children; and six grandchildren.
Neurobehavioral effects of power-frequency electromagnetic fields.
Authors: N Paneth
Journal: Environmental Health Perspectives (1993)

Some laboratory experiments have suggested that power-frequency electric and magnetic fields (EMF) may be capable of influencing calcium efflux from cell membranes, pineal function, and circadian rhythms. As yet, however, no consistent, replicable laboratory model has been developed for any of these effects. Most assessments of human volunteers exposed to EMF have been negative, but occasional effects on vigilance or alertness and some modest effects on circadian rhythmicity have been reported. Several carefully performed studies of workers occupationally exposed to high electric-field strengths have failed to find effects on behavior or cognitive functioning. Although the bulk of human research on the effects of EMF on cognitive performance is negative, there has been less assessment of behavior and psychiatric symptomatology. Because some studies, in both humans and animals, have described effects of EMF on circadian rhythms, future research might concentrate profitably on the assessment of EMF in relation to depression and other cyclically mediated psychiatric disorders.
NHS costs could rise and emergency care suffer under health bill, says leaked risk register
Authors: C. Dyer
Journal: BMJ (2012)

The NHS may be less able to handle emergencies and the healthcare system could become more costly once major changes to the health service in England go through, says a leaked draft of a document which the UK government has fought to keep under wraps.

The draft of the transition risk register, leaked to the health writer Roy Lilley, outlines a range of dangers arising from the reforms, along with action needed to mitigate them.

The “draft for discussion,” dated September 2010, has emerged on the day the Health and …
A scanning electron microscopic study of postnatal development of rat peribiliary plexus
Authors: Joji Haratake, Masanori Hisaoka, Akiko Furuta, Akio Horie, Osamu Yamamoto
Journal: Hepatology (1991)

Hepatic microcirculation in the developing stages is not fully clarified. This study aimed at clarifying the development of hepatic microcirculation, especially peribiliary vascular plexuses, in neonatal rats by corrosion cast procedures and scanning electron microscopy. Peribiliary vascular plexuses of large bile ducts at the hilus of 1-day-old rats showed a simple capillary network that directly poured into the portal vein. The hepatic artery promptly tapered down into many small branches and ended in sinusoids or capillary plexuses around portal vein branches near the hilus. Neither apparent hepatic artery branches nor peribiliary vascular plexuses were found in the peripheral areas of the liver. On the seventh day, very loose peribiliary vascular plexuses and small hepatic artery branches appeared up to the peripheral portal tracts, and the peribiliary vascular plexuses of large bile ducts were still capillary networks. After the seventh day, peribiliary vascular plexuses of large and medium-sized portal tracts often poured into side branches of the portal vein rather than directly into the portal vein as shown in the rats from the first day mentioned above. Peribiliary vascular plexuses of the large bile duct in 2-week-old rats showed a double layer, that is, an outer layer composed of arteries and veins and an inner layer of capillary vessels, that resembled peribiliary vascular plexuses of adult livers. After nearly 4 wk, hepatic microcirculations had almost fully developed into those of adult rats. It was concluded that the gradual postnatal development of the hepatic arterial system and the peribiliary vascular plexuses occurred in parallel with the maturation of the intrahepatic biliary trees.
Direct Comparison of Tc-99m DTP A and Tc-99m HMPAO for Evaluating Brain Death
Authors: MICHAEL E. SPIETH, AZIZULLAH N. ANSARI, TOM K. KAWADA, ROBYN L KIMURA, MICHAEL E. SIEGEL
Journal: Clinical Nuclear Medicine (1994)

Portable cerebral perfusion studies provide a quick and accurate alternative to traditional confirmatory examinations (such as four-vessel angiography and electroencephalography) to determine brain death. The authors retrospectively analyzed 26 cerebral perfusion studies using both Tc-99m DTPA and Tc-99m HMPAO. The flow agents gave identical results. Additionally, the delayed-phase Tc-99m HMPAO images gave the same results for brain death (14 positive and 12 negative) as the flow images from either agent. Because the Tc-99m HMPAO delayed images can be used for diagnosis, many technical problems become less crucial. Unlike Tc-99m DTPA, Tc-99m HMPAO normally visualizes the gray matter of the cerebellum, midbrain, and medulla. These areas must be evaluated to ensure that they meet the strict criteria for brain death. These differences and the present study suggest that Tc-99m HMPAO is a superior agent for cerebral perfusion studies to determine brain death.
Privy Council again overturns GMC ruling
Authors: O. Dyer
Journal: BMJ (2003)

A consultant surgeon who was struck off by the General Medical Council has been reinstated after successfully appealing to the Privy Council, claiming that procedural irregularities had denied him a fair hearing.

Steven Walker, who worked at Blackpool Victoria Hospital from 1995 to 1998, was struck off after a series of mismanaged operations left five patients dead from bleeding ( BMJ 2001;323:652).

He is the third doctor since the beginning of 2002 to have successfully appealed to the Privy Council against a finding of the GMC.

Walker did not deny the finding of serious professional misconduct but appealed on …
HIV-1 infected patients older than 50 years. PISCIS cohort study
Authors: G. Navarro, M.M. Nogueras, F. Segura, J. Casabona, J.M. Miro, J. Murillas, C. Tural, E. Ferrer, A. Jaén, L. Force, J. Vilaró, I. García, A. Masabeu, J. Altés, A. Esteve, O. Sued, M. Riera, B. Clotet, D. Podzamczer, J.M. Gatell
Journal: Journal of Infection (2008)
Delirium in older people
Authors: John Young, Sharon K Inouye
Journal: BMJ (2007)

Few ill health situations are more degrading to people of any age than loss of reasoning, faculties, and personhood. These are the unpleasant consequences of delirium—a common condition affecting ill older people, particularly those with some degree of dementia. It is characterised by recent onset of fluctuating inattention and confusion, linked to one or more triggering factors. 

#### SUMMARY POINTS 

Delirium is a major burden to healthcare services and has been largely ignored by health service planners and practitioners.1 Moreover, healthcare systems and services often unintentionally stimulate or substantially aggravate the development of delirium in older people.2 This might be understandable if delirium was unavoidable or untreatable, but the existing evidence base for delirium is sufficiently robust for prevention or attenuation of the condition to be a realistic proposition. There is a pressing need to take this action because the outcomes for delirium are poor: it contributes to substantial morbidity and mortality, causes considerable distress to patients and families, and is expensive—an estimated additional $2500 (£1275; €1875) per patient (a $6.9bn annual expenditure for Medicare in 2004).3

We searched Medline and the Cochrane Library from 1996 to 2006. We drew additional material from our personal libraries of delirium references, focusing particularly on systematic reviews.

Delirium is an important problem for all clinical services providing care for older people, particularly emergency departments; general medical, elderly care, surgical, and …
Heart rate spectral analysis, cardiac norepinephrine spillover, and muscle sympathetic nerve activity during human sympathetic nervous activation and failure.
Authors: B A Kingwell, J M Thompson, D M Kaye, G A McPherson, G L Jennings, M D Esler
Journal: Circulation (1994)

BACKGROUND Although heart rate variability (HRV) at 0.1 Hz has been proposed as a noninvasive clinical measure of cardiac sympathetic nerve firing, this premise has not been sufficiently validated by comparison with techniques such as microneurography and the measurement of norepinephrine spillover from the heart that more directly reflect presynaptic sympathetic activity. METHODS AND RESULTS We compared the three techniques under conditions of effective cardiac sympathetic denervation, pure autonomic failure (n = 4), dopamine beta-hydroxylase deficiency (n = 1), and after cardiac transplantation (n = 9) as well as in the context of sympathetic nervous activation in cardiac failure (n = 15) and with aging (n = 10). Age-matched comparisons were made in each case with healthy individuals drawn from a pool of 52 volunteers. In pure autonomic failure and early after transplantation, cardiac norepinephrine spillover was negligible, and HRV was low. Late after transplantation, however, cardiac norepinephrine spillover returned to normal levels, and HRV remained low. In comparison to younger subjects (18 to 35 years old), older individuals (60 to 75 years old) had higher muscle sympathetic nerve activity (young, 22.9 +/- 1.9; old, 31.3 +/- 5.8 bursts per minute; P &lt; .05) and cardiac norepinephrine spillover (young, 14.3 +/- 2.5; old, 20.1 +/- 3.0 ng/min; P &lt; .05). In contrast, total HRV was reduced by 89%, and at 0.1 Hz it was reduced by 93% (P &lt; .05). Cardiac failure was also characterized by elevated cardiac norepinephrine spillover (cardiac failure patients, 59 +/- 4; healthy volunteers, 18 +/- 3 ng/min; P &lt; .01) but reduced 0.1 Hz HRV (cardiac failure patients, 49 +/- 17; healthy volunteers, 243 +/- 4 ms2; P &lt; .05). CONCLUSIONS HRV at 0.1 Hz depends on factors in addition to cardiac sympathetic nerve firing rates, including multiple neural reflexes, cardiac adrenergic receptor sensitivity, postsynaptic signal transduction, and electrochemical coupling, and is not directly related to cardiac norepinephrine spillover, which is a more direct measure of the sympathetic nerve firing rate.
Abstract LB-121: Tumor suppressor p53 is involved in a CHAMP-dependent spindle assembly checkpoint pathway.
Authors: Piyan Zhang, Erica Ungewitter, Ettore Appella, Heidi Scrable
Journal: Cancer Research (2013)

Abstract A p53-dependent mouse spindle checkpoint has been reported since 1995. However the underlying mechanism is still unknown. Here, we found that p53 formed complexes with CHAMP and MAD2L2. Immunofluorescence analysis revealed that p53, CHAMP and MAD2L2 colocalized at spindle fibres from pro-metaphase to anaphase. CHAMP binds MAD2L2 and antagonizes its inhibition function on APC/C. We discovered that p53 enhanced the inhibition of MAD2L2 by CHAMP. P53 knock-down decreased M-phase index. Exogenous expression of p53 increased M-phase index and extended remarkable length of time in M phase. Notably, the regulation of p53 on M phase index was completely abrogated by either CHAMP or MAD2l2 knock-down, suggesting that the regulation of p53 on spindle assembly checkpoint pathway is dependent on CHAMP and MAD2L2. These results demonstrate that p53 participates in a mitotic checkpoint that ensures the maintenance of genetic fidelity during development. Citation Format: Piyan Zhang, Erica Ungewitter, Ettore Appella, Heidi Scrable. Tumor suppressor p53 is involved in a CHAMP-dependent spindle assembly checkpoint pathway. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-121. doi:10.1158/1538-7445.AM2013-LB-121