tbuckley/cabot-search huggingface dataset:
Relation between the minimum RR interval during atrial fibrillation and the functional refractory period of the AV junction
Authors: J. BILLETTE, R. A. NADEAU, F. ROBERGE
Journal: Cardiovascular Research (1974)

Journal Article Relation between the minimum RR interval during atrial fibrillation and the functional refractory period of the AV junction Get access JACQUES BILLETTE, JACQUES BILLETTE From the Department of Physiology, Faculty of Medicine, University of Montreal, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar RÉGINALD A. NADEAU, RÉGINALD A. NADEAU From the Department of Physiology, Faculty of Medicine, University of Montreal, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar FERNAND ROBERGE FERNAND ROBERGE From the Department of Physiology, Faculty of Medicine, University of Montreal, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 8, Issue 3, May 1974, Pages 347–351, https://doi.org/10.1093/cvr/8.3.347 Published: 01 May 1974
The natural course of gold nephropathy
Authors: C. L Hall
Journal: BMJ (1988)

capable of producing both superoxide and hydrogen peroxide with the reintroduction of the blood supply.5Dr Murrel and his colleagues have found that the xanthine oxidase inhibitor allopurinol is of benefit in Depuytren's contracture.6Although this trial was uncontrolled we have been unable to find reports of spontaneous resolution in published reports.It would be of interest to estab- lish whether allopurinol supresses the destructive consequences of inflammatory tenosynovitis asso- ciated with rheumatoid disease.
Liquid nitrogen cryotherapy of common warts: cryo-spray vs. cotton wool bud: reply from authors
Authors: I. Ahmed, J. Berth-Jones
Journal: British Journal of Dermatology (2002)

Sir, We would like to thank Dr Kuwahara for his comments on our study. We have shown that liquid nitrogen is equally effective in treating common warts when applied either with a cryo‐spray or a cotton wool bud (CWB).1 Prior to our study,␣existing data relating to the response to cryotherapy were virtually all derived from the use of a CWB as the applicator.2–4 Cryo‐spray guns have been in common use for many years. The liquid nitrogen is kept in a closed flask under pressure and has a safety‐valve mechanism. They have a variety of tips and attachments to control the volume and direction of spray. We would agree with Dr Kuwahara that the cryo‐spray gun is quite elegant and easy to use. Application of liquid nitrogen with a CWB is also quite easy to master, although not so elegant. When treating young children, the appearance and sound of the cryo‐spray can be quite intimidating, and the CWB method may be preferred.
Health-Related Quality of Life Predicts Mortality in Patients With Advanced Chronic Liver Disease
Authors: Fasiha Kanwal, Ian M. Gralnek, Ron D. Hays, Angelique Zeringue, Francisco Durazo, Steven B. Han, Sammy Saab, Roger Bolus, Brennan M.R. Spiegel
Journal: Clinical Gastroenterology and Hepatology (2009)
<i>PNPLA3</i>(rs738409 C&gt;G) is a common risk variant associated with hepatocellular carcinoma in alcoholic cirrhosis
Authors: Eric Trepo, Erwan Guyot, Nathalie Ganne-Carrie, Delphine Degre, Thierry Gustot, Denis Franchimont, Angela Sutton, Pierre Nahon, Christophe Moreno
Journal: Hepatology (2011)

A common variant (rs738409 C>G) in the PNPLA3 gene has been consistently associated with liver fat but also fibrosis in nonalcoholic fatty liver disease, alcoholic liver disease (ALD), and chronic hepatitis C (CHC).1-4 The study by Valenti et al.4 in a recent issue of HEPATOLOGY shows that in Caucasian CHC patients, this variant was also linked to hepatocellular carcinoma (HCC). This latter finding has been replicated in another independent European cohort.5 We tested the association between rs738409 and HCC in ALD. To this end, we genotyped 325 Caucasian patients from Belgium with alcoholic cirrhosis (67% men; mean age, 54.9 ± 9.1 years; mean body mass index [BMI], 26.7±5.5 kg/m2; 17% had diabetes) and 246 French Caucasian patients with alcoholic cirrhosis (86% men; mean age, 64.3±9.1 years; mean BMI, 27.4±4.9 kg/m2; 37% had diabetes). HCC was confirmed by histology or typical imaging findings in 12% of the Belgian cohort and 43% of the French cohort. The French unit included a higher proportion of HCC patients, reflecting the specificity of this tertiary center specializing in liver cancer management. HCC was present in 9% of CC, 10% of CG, and 25% of GG genotype in the Belgian cohort and in 28% of CC, 41% of CG, and 78% of GG genotype in the French group. The minor allele frequency was not statistically different between the Belgian and French centers (36.8% versus 39.8% [P = 0.296]). Under a recessive model of inheritance, rs738409 was significantly associated with HCC after adjustment for, age, sex, BMI, and diabetes in both cohorts (Table 1). The rs738409 variant is associated with liver fat accumulation; however, the exact function of PNPLA3 and the consequence of the related nonsynonymous variation remains unknown.6 Although the remarkable observation that rs738409 confers higher risk of HCC in CHC and ALD warrants additional replication, it may well illustrate gene-host interactions and indicate that the influence of PNPLA3 on chronic liver disease heritability could go far beyond a mere impact on steatosis. Eric Trépo* , Erwan Guyot §, Nathalie Ganne-Carrié¶, Delphine Degré* , Thierry Gustot* , Denis Franchimont* , Angela Sutton §, Pierre Nahon¶ **, Christophe Moreno M.D., Ph.D.* , * Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology, Erasme Hospital, Laboratory of Experimental Gastroenterology, Université Libre de Bruxelles, Brussels, Belgium, INSERM U6988, Université Paris 13, Bobigny, France, § Service de Biochimie, Hŏpital Jean Verdier, AP-HP, Bondy, France, ¶ Service d'Hépatologie, Hŏpital Jean Verdier, AP-HP, Bondy, France, ** INSERM U773, Centre de Recherche Bichat Beaujon CRB3, Université Paris 7, Paris, France.
THE NATURE OF THE IMMUNOLOGIC INADEQUACY OF NEONATAL RABBITS AS REVEALED BY CELL TRANSFER STUDIES
Authors: Frank J. Dixon, William O. Weigle
Journal: The Journal of Experimental Medicine (1957)

Lymph node cells capable of either primary or secondary antibody responses following transfer to adult normal or x-radiated homologous recipients make no response following transfer to neonatal homologous recipients. On the basis of the present observations it seems that the environment provided by the neonatal recipient is unsuitable for the immunologic activities of transferred cells in the early phases of the immune response. Neonatal recipients can, however, adequately support cells transferred during the process of active antibody formation. These findings suggest that the immunologic inadequacy of the neonatal animal is related to its internal environment and not necessarily to the lack of cells capable of antibody synthesis.
Abstract 4723: HO-3867, a STAT3 inhibitor induces G2/M arrest and apoptosis in BRCA1-mutated ovarian cancer cells
Authors: Brent J. Tierney, Georgia McCann, David E. Cohn, Meryl Sudhakar, David O'Malley, Selvendiran Karuppaiyah
Journal: Cancer Research (2012)

Abstract Background: BRCA1 plays an important role in DNA damage and repair, homologous recombination, cell-cycle regulation, and apoptosis. BRCA-mutated ovarian cancer often presents at an advanced stage, however, patients have shown improved responses with platinum-based chemotherapy versus sporadic cases. In spite of this, most patients will develop a recurrence and eventually succumb to the disease. Preclinical studies are currently investigating natural compounds and their analogs for tumor-directed targets in ovarian cancer cell models. The aim of this study is to investigate whether the STAT3 inhibitor HO-3867, a novel curcumin analog, has a therapeutic effect on BRCA1-mutated ovarian cancer. Methods: Expression of STAT family proteins, cell cycle, apoptotic and DNA repair proteins were evaluated via western blot on BRCA- mutated and non-mutated ovarian cancer cell lines. Cell viability and proliferation were analyzed with MTT and clonogenic assays. Cell cycle analysis and apoptosis assays were performed using flow cytometry and Annexin V staining. Reactive oxygen species (ROS) staining was performed using immunofluoresence. Finally, STAT3 overexpression or suppression experiments were performed using transfected wild-type STAT3 cDNA and STAT3 siRNA, respectively. Results: Our novel agent, HO-3867, and a commercial STAT3 inhibitor, STATIC, significantly inhibited BRCA-mutated cancer cells in vitro, in a dose-dependent manner. HO-3867 induced G2/M arrest with increased expression of p53 and p21 and with decreased cdk5 and cyclin D1 expression. BRCA-mutated cells treated with HO-3867 exhibited an increased induction of apoptosis with elevated levels of cleaved caspase-3, caspase-7, and PARP. Tyrosine-phosphorylated STAT3 (pTyr705) exhibited higher expression levels in BRCA-mutated cancer cells compared with other STAT proteins. Furthermore, treatment of these cells with HO-3867 resulted in decreased expression of pTyr705 and other DNA repair proteins. In addition, HO-3867 treatment induced more ROS in BRCA-mutated cells compared with wild-type cells, with no increased induction in benign ovarian surface epithelial cells. Furthermore, we confirmed that the over-expression of STAT3 cDNA provides resistance to HO-3867 induction of apoptosis. Conclusion: Our results show that HO-3867, a potential STAT3 inhibitor, may be effective in the treatment of BRCA-mutated ovarian cancer, although continued studies are needed to elucidate the exact mechanism of action. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4723. doi:1538-7445.AM2012-4723
Transfused Stored Blood and Oxygen Delivery in Patients With Sepsis
Authors: Ajay Anand
Journal: JAMA (1993)

To the Editor.  —The study by Drs Marik and Sibbald1was interesting and thought-provoking. The authors make a very important clinical point relating to the role of red blood cell transfusions in the therapy of the septic patient. In this regard, I would like to highlight some additional data relevant to the subject.  The authors comment on reduced 2,3 diphosphoglycerate, adenosine triphosphate, and red blood cell deformability as the factors responsible for the lowered oxygen consumption following stored red blood cell transfusion. Studies of banked blood have revealed other possibly significant changes in red blood cells over time. Uchida and coworkers2showed that methemoglobin levels increased during storage (from 1.3% to 2.4% in 3 weeks), while carboxyhemoglobin levels remained high (range, 0% to 9.6%) with a half-life of 47 days. It is suggested that the use of banked blood containing high levels of these abnormal hemoglobins may pose
Adverse Events Related to Muraglitazar Use in Diabetes
Authors: David M. Najman
Journal: JAMA (2006)

To the Editor: The study of muraglitazar and adverse events by Dr Nissen and colleagues points out why physicians need hard outcomes data obtained in a blinded fashion before prescribing a new therapy for patients. The study, however, raises broader concerns beyond muraglitazar. Mortality data are needed prior to US Food and Drug Administration (FDA) approval for peroxisome proliferator–activated receptor (PPAR) agonists, and current practices that use combined therapy for patients with diabetes who have lipid abnormalities need to be examined. There is a relative paucity of mortality data for fibric acid derivatives compared with data on statins. One of the 3 large studies examining the use of gemfibrozil in the secondary prevention of cardiovascular disease showed a nonstatistically significant 7% increase in total mortality. Another study showed a nonsignificant benefit for gemfibrozil, with a 10% reduction in total mortality. Bezafibrate was reported to have a nonsignificant 6% higher mortality. These studies were not designed as mortality trials, but there are no published data demonstrating convincing mortality benefit with the use of fibric acid derivatives. Diabetic dyslipidemia typically refers to patients with a high triglyceride–low high-density lipoprotein (HDL) profile, who are the patients most suitable for PPARagents. These patients may receive PPARand PPARagents as 2 different pills, and the interaction of these was not previously known. The fibric acid studies were all conducted in different patient populations, and it is not clear how many patients in each group were also taking PPARagents. However, with limited data supporting a mortality benefit for fibric acids alone, and the apparent increase in mortality seen with muraglitazar, caution should be used in prescribing any fibric acid along with any PPARagent because this combination may have the same propensity to increased mortality.
Reefer Madness — The Federal Response to California's Medical-Marijuana Law
Authors: George J. Annas
Journal: New England Journal of Medicine (1997)

Marijuana is unique among illegal drugs in its political symbolism, its safety, and its wide use. More than 65 million Americans have tried marijuana, the use of which is not associated with increased mortality.1 Since the federal government first tried to tax it out of existence in 1937, at least partly in response to the 1936 film Reefer Madness, marijuana has remained at the center of controversy. Now physicians are becoming more actively involved. Most recently, the federal drug policy against any use of marijuana has been challenged by California's attempt to legalize its use by certain patients on the . . .
Abstract 495: Inactive status of cancer cells with suppression of AKT activity contributes to survival in chronic hypoxia
Authors: Masahiro Inoue, Hiroaki Okuyama, Hiroko Endo, Masayuki Ohue
Journal: Cancer Research (2014)

Abstract A hypoxic microenvironment in tumors has been recognized as a cause of malignancy or resistance to various cancer therapies. In contrast to the recent progress in understanding the acute response of cancer cells to hypoxia, the characteristics of tumor cells in chronic hypoxia remain elusive. We have identified a pancreatic cancer cell line, AsPC-1, which is exceptionally able to survive for weeks under hypoxic conditions (1%O2) without changing medium at all, while most of the tested cancer cell lines died after several days under these conditions. Under hypoxic conditions, the AsPC-1 cells entered an “inactive status” characterized by no proliferation or death and by metabolic suppression. They recovered to active status after being placed again in optimal culture conditions. Under chronic hypoxia, ATP turnover, an indicator of energy demand, was markedly decreased, as was AKT phosphorylation. Forced activation of AKT resulted in increased ATP turnover and massive cell death in vitro. Xenograft tumors generated with AKT over-expressing cells showed remarkable decrease of inactive zone, where BrdU uptake and S6 phosphorylation were eliminated without any sign of cell death. We recently developed a novel culture system for primary cancer cells. In contrast to most cancer cell lines, primary colorectal cancer cells entered inactive status with AKT suppression under hypoxia combined with growth factor-depleted conditions. The ability of cancer cells to survive in a deteriorated microenvironment by entering into an inactive status might be a common property among cancer cells. The cancer cells in inactive status of both primary cultured cancer cells and AsPC-1 cells were resistant to chemotherapy. Targeting the regulatory mechanism inducing this inactive status might provide a new strategy for overcoming resistance to various cancer therapies. Citation Format: Masahiro Inoue, Hiroaki Okuyama, Hiroko Endo, Masayuki Ohue. Inactive status of cancer cells with suppression of AKT activity contributes to survival in chronic hypoxia. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 495. doi:10.1158/1538-7445.AM2014-495
Cardiovascular MRI in Congenital Heart Disease: An Imaging Atlas
Authors: Daniel Cornfeld
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Demonstration of Peripheral Conduction System in Human Hearts
Authors: MADISON S. SPACH, SHAO-NAN HUANG, SARA I. ARMSTRONG, RAMON V. CANENT
Journal: Circulation (1963)

The peripheral conduction system was demonstrated grossly by iodine staining in a normal newborn heart and in one with a muscular ventricular septal defect. Staining of the conduction system was unsuccessful in a third heart when attempted over 2 hours after death. The left ventricular conduction system was easily visualized; however, the arborizations of conduction tissue over the right ventricular free wall endocardium were demonstrated poorly.
The Diagnosis and Treatment of Pneumocystis carnii Pneumonia.
Authors: David Rifkind
Journal: Annals of Internal Medicine (1966)

s1 May 1966The Diagnosis and Treatment of Pneumocystis carnii Pneumonia.David Rifkind, M.D., Rolla B. Hill Jr., M.D.David Rifkind, M.D.Search for more papers by this author, Rolla B. Hill Jr., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-5-1168_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSeventy-five patients were treated in the first renal transplantation series at the University of Colorado Medical Center from November, 1962, to March, 1964, with a mortality rate of 49%. Pneumonia attributed toPneumocystis cariniioccurred in 11 patients and was fatal in 6. All patients were receiving azathioprine and prednisone at the onset of pneumonia. The disease was characterized by an insidious onset, dry cough, fever, tachypnea, and cyanosis. The chest roentgenograms showed bilateral alveolar and nodular infiltrates without adenopathy or pleural reaction. The cold hemagglutinin titers were elevated in four patients. Pulmonary function studies in three patients revealed an... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Denver, Colorado PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1966Volume 64, Issue 5Page: 1168-1169KeywordsDeath ratesFeversPneumocystisPneumoniaPulmonary functionRenal transplantationTachypneaThorax Issue Published: 1 May 1966 PDF DownloadLoading ...
Treadmill test responses to an early exercise program after myocardial infarction: a randomized study.
Authors: E S Sivarajan, R A Bruce, B D Lindskog, M J Almes, L Belanger, B Green
Journal: Circulation (1982)

The effects of an exercise program started early after myocardial infraction and the added effects of an outpatient teaching-counseling program were studied. At random, 84 patients were allocated to a control group (A), 88 patients to an exercise group (B1) and 86 patients to an exercise and teaching-counseling group (B2). The same exercise program was prescribed for patients in groups B1 and B2 and was started about 4.5 days after myocardial infarction and continued for 3 months. The outpatient teaching-counseling program consisted of eight group sessions pertaining to risk factor reduction and psychosocial adjustment to myocardial infraction. A low-level treadmill test and an exercise test were performed at 3 months and the exercise test was repeated at 6 months. The clinical, hemodynamic and electrocardiographic responses to these tests were not different among the three groups. However, by the end of 3 months, patients in group B1 and B2 reported walking greater distances than patients in group A. The incidence of morbidity and mortality was not different between the groups. No deleterious or beneficial physiologic effects of an exercise program either by itself or combined with a teaching-counseling program were demonstrated. Routine medical care and our interventions were equally effective in permitting the spontaneous hemodynamics improvements after myocardial infraction. More than 3 months after myocardial infarction, the group as a whole manifested spontaneous recovery in the form of a significant decrease in resting heart rate (p less than 0.001) and a significant increase in systolic and diastolic blood pressure at rest and with submaximal exercise (p less than 0.001). No further improvements were observed between 3 and 6 months.
Phenylbutazone
Authors: William C. Kuzell, Ralph W. Schaffarzick, W. Edward Naugler, Barbara M. Champlin
Journal: New England Journal of Medicine (1957)

IN the treatment of chronic rheumatic diseases experience teaches that from a large selection of pharmacologic agents "many are called but few are chosen." Initial enthusiasm for new medications is usually tempered by prolonged clinical evaluation. Original therapeutic success may wane, or the incidence of toxic manifestations may increase. Progress reports are therefore desirable to determine whether a new drug merits a permanent place in the clinical armamentarium.In 1953 experience with phenylbutazone in the treatment of 800 patients with a variety of diseases was described.1 At that time this pyrazole was considered of greatest value in gout and useful, . . .
CASE OF DOUBLE CONGENITAL LUXATION OF THE HIPS: ONE REPLACED BY MANIPULATION AND THE OTHER BY OPERATION.
Authors: GWILM G. DAVIS
Journal: JAMA (1900)

The patient, a little over 5 years of age, started to walk when 9 months old. It was noticed that her gait was unnatural and, as she grew older, her back became hollow and her buttocks prominent. At the age of 3½ years, after she had been walking for two years and nine months, she came under my care at the Orthopœdic Hospital. She then possessed the marked waddling gait of this affection. Lordosis was quite marked, the hollow in the back being pronounced. Both trochanters were well above Nélaton's line. In standing she did not hold herself perfectly erect, but slightly flexed both the hips and the knees. Ether was administered and tenotomy of the adductors of both thighs performed. Then, by manipulation, both femurs were restored to their sockets. Both the luxations being dorsal ones, the limbs were put up in plaster of Paris, in an abducted and