Screening for Pancreatic Disease
Authors: JOHN M. TIERNEY
Journal: Annals of Internal Medicine (1963)

Article1 February 1963Screening for Pancreatic DiseaseJOHN M. TIERNEY, M.D., JOHN F. CARTER, M.D., GUY E. VAN GOIDSENHOVEN, M.D., WILLIAM A. KNIGHT JR., M.D., F.A.C.P.JOHN M. TIERNEY, M.D.Search for more papers by this author, JOHN F. CARTER, M.D.Search for more papers by this author, GUY E. VAN GOIDSENHOVEN, M.D.Search for more papers by this author, WILLIAM A. KNIGHT JR., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-2-229 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical findings of chronic pancreatitis or pancreatic neoplasm may be so mild or atypical that the diagnosis is not suspected, diagnostic studies not requested, or hospitalization not indicated. Thus, many cases may long go unrecognized or may be diagnosed as functional. Many workers have demonstrated that the diagnosis of chronic pancreatic disease can be improved with the use of elaborate studies (1-17), especially duodenal drainage with chemical (6-9) and cytological (10, 11) analysis of the aspirate after stimulation with secretin alone or with secretin and pancreozymin (12, 13) and a 72-hour quantitative stool fat analysis on a control diet...References1. ALTHAUSENUYEYAMA TLK: A new test of pancreatic function based on starch tolerance. Ann. Intern. Med. 41: 563, 1954. LinkGoogle Scholar2. NUGENTMILLHON FWWA: Clinical evaluation of the starch tolerance test. JAMA 168: 2260, 1958. CrossrefMedlineGoogle Scholar3. DUFFYTURNER BJDA: The use of radioactive-labeled oral fat in the evaluation of pancreatic function. Cancer 11: 33, 1958. CrossrefMedlineGoogle Scholar4. POLLOCK AV: Pancreatography in the diagnosis of chronic relapsing pancreatitis. Surg. Gynec. Obstet. 107: 765, 1958. MedlineGoogle Scholar5. MOSELEY RD: Diagnosis of tumors of the pancreas with the aid of pneumoretroperitoneal pancreatography and splenoportography. Amer. J. Roentgenol. 80: 967, 1958. Google Scholar6. ACRENLAGERLOFBERFUND GHH: The secretin test of pancreatic function in the diagnosis of pancreatic disease. Acta Med. Scand. 90: 224, 1936. CrossrefGoogle Scholar7. DREILINGJANOWITZ DAHD: The laboratory diagnosis of pancreatic disease: secretin test. Amer. J. Gastroent. 28: 268, 1957. MedlineGoogle Scholar8. DIAMONDSIEGEL JSSA: The secretin test in the diagnosis of pancreatic disease with a report of 130 tests. Amer. J. Dig. Dis. 7: 435, 1940. CrossrefGoogle Scholar9. POLLARDMILLERBREWER HMLWA: A clinical study of the secretin test. Amer. J. Dig. Dis. 9: 68, 1942. CrossrefGoogle Scholar10. RASKINWENGERSKLARPLETICKEYAREMA HFJMSW: The diagnosis of cancer of the pancreas, biliary tract, and duodenum by combined cytologic and secretory methods. I. Exfoliative cytology and a description of rapid method of duodenal intubation. Gastroenterology 34: 996, 1958. CrossrefMedlineGoogle Scholar11. WENGERRASKIN JHF: The diagnosis of cancer of the pancreas, biliary tract, and duodenum by combined cytologic and secretory methods. II. The secretin test. Gastroenterology 34: 1009, 1958. CrossrefMedlineGoogle Scholar12. SUNSHAY DCH: Pancreozymin-secretin test. The combined study of serum enzyme and duodenal contents in the diagnosis of pancreatic disease. Gastroenterology 38: 570, 1960. CrossrefMedlineGoogle Scholar13. BURTONEVANSHARPERHOWATOLEESKYSCOTTVARLEY PDGAAHTSJEH: A test of pancreatic function in man based on the analysis of duodenal contents after administration of secretin and pancreozymin. Gut 1: 111, 1960. CrossrefMedlineGoogle Scholar14. VAN DE KAMERTEN BOKKEL HUININKWEYERS JHHHA: Rapid method for the determination of fat in feces. J. Biol. Chem. 177: 347, 1949. CrossrefMedlineGoogle Scholar15. COFFEYMANNBOLLMANN RJFCJL: The influence of the pancreas on the utilization of foodstuffs. Amer. J. Dig. Dis. 7: 144, 1940. CrossrefGoogle Scholar16. PESSOAKIMIVY VCKSAC: Fat absorption in absence of bile and pancreatic juice. Amer. J. Physiol. 174: 209, 1953. CrossrefMedlineGoogle Scholar17. VOLWILER W: Gastrointestinal malabsorptive syndromes. Amer. J. Med. 23: 250, 1957. CrossrefMedlineGoogle Scholar18. HENKEVACCAVAN GOIDSENHOVENKNIGHT WJJBGEWA: Evaluation of pancreatic function tests in confirmed pancreatic disease. Gastroenterology 41: 233, 1961. CrossrefMedlineGoogle Scholar19. SOMOGYI M: Micromethods for the estimation of diastase. J. Biol. Chem. 125: 399, 1938. CrossrefGoogle Scholar20. FOLIN O: The determination of sugar in blood and in normal urine. J. Biol. Chem. 67: 357, 1926. CrossrefGoogle Scholar21. SULLIVANKNIGHT JFWA: Serial serum diastase studies. Amer. J. Dig. Dis. 5: 246, 1960. CrossrefMedlineGoogle Scholar22. BUDDWALTERHARRISKNIGHT JJKEMLWA: Urine diastase in the evaluation of pancreatic disease. Gastroenterology 36: 333, 1959. CrossrefMedlineGoogle Scholar23. SUNSHAY DCH: Value of combined study of serum enzymes and duodenal contents after secretin in the diagnosis of diseases of the pancreas. Gastroenterology 32: 212, 1957. CrossrefMedlineGoogle Scholar24. LOPUSNIAKBOCKUS MSHL: Study of pancreatic serum enzymes following secretin injection in pancreatic affections. Gastroenterology 16: 294, 1950. CrossrefMedlineGoogle Scholar25. DREILINGRICHMAN DAA: Evaluation of provocative blood enzyme tests employed in diagnosis of pancreatic disease. Arch. Intern. Med. 94: 197, 1954. CrossrefGoogle Scholar26. HEFFERNONGUNTER EWAR: Evaluation of the secretin test in pancreatic disease. Gastroenterology 19: 526, 1951. CrossrefMedlineGoogle Scholar27. BURTONHAMMONDHARPERHOWATSCOTTVARLEY PEMAAHTJEH: Serum amylase and serum lipase levels in man after administration of secretin and pancreozymin. Gut 1: 125, 1960. CrossrefMedlineGoogle Scholar28. KNIGHTMUETHERSOMMER WAROAJ: Chronic recurrent pancreatitis. II. Serial serum diastase levels following prostigmine stimulation. Gastroenterology 12: 34, 1949. CrossrefMedlineGoogle Scholar29. SIMKOSIMONCIC VR: The diagnostic value of the prostigmine test in chronic pancreatopathies. Gastroenterologia 97: 21, 1962. CrossrefMedlineGoogle Scholar30. ABRUZZOHOMAHOUCKCOFFEY JLMJCRJ: Significance of the serum amylase determination. Ann. Surg. 147: 921, 1958. MedlineGoogle Scholar31. JANOWITZDREILING HDDA: The plasma amylase. Amer. J. Med. 27: 924, 1959. CrossrefMedlineGoogle Scholar32. SOMOGYI M: Blood diastase in health and disease. J. Biol. Chem. 134: 315, 1940. CrossrefGoogle Scholar33. STREET HV: Serum amylase activity, its determination in health and in diabetes mellitus. Clin. Chim. Acta 3: 501, 1958. CrossrefMedlineGoogle Scholar34. SOMOGYI M: Diastatic activity of human blood. Arch. Intern. Med. 67: 665, 1941. CrossrefGoogle Scholar35. GRAYPROBSTEINHEIFETZ SHJGCJ: Clinical studies on blood diastase. 1. Low blood diastase as an index of impaired hepatic function. Arch. Intern. Med. 67: 805, 1941. CrossrefGoogle Scholar36. MCGEACHINLEWIS RLJP: Electrophoretic behavior of serum amylase. J. Biol. Chem. 234: 795, 1959. CrossrefMedlineGoogle Scholar37. SAXONHINKLEYVOGELZIEVE EIWCWCL: Comparative values of serum and urinary amylase in the diagnosis of acute pancreatitis. Arch. Intern. Med. 99: 607, 1957. CrossrefGoogle Scholar38. SACHARWEINHAUS LAR: Misinterpretation of elevated blood diastase due to impaired renal function. Arch. Surg. 73: 305, 1956. CrossrefGoogle Scholar39. HEIFETZSACHARBIRENBAUMSICHER CJLAAN: Blood and urinary diastase in renal azotemia; interrelationships and prognostic significance. J. Urol. 76: 346, 1956. CrossrefMedlineGoogle Scholar40. KNIGHTSTERKELVAN GOIDSENHOVEN WARLGE: Unpublished data. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN M. TIERNEY, M.D.; JOHN F. CARTER, M.D.; GUY E. VAN GOIDSENHOVEN, M.D.; WILLIAM A. KNIGHTJR., M.D., F.A.C.P.Affiliations: St. Louis, MissouriFrom the Division of Gastroenterology, Department of Medicine, St. Louis University School of Medicine, St. Louis, Missouri.This investigation was supported by United States Public Health Service training grant 2A-5149 from the National Institute of Arthritis and Metabolic Diseases.Presented in part at the Regional Meeting of the American College of Physicians, Columbia, Missouri, February 24, 1962.Drs. Tierney and Carter are Fellows in Gastroenterology.Requests for reprints should be addressed to William A. Knight, Jr., M.D., Department of Internal Medicine, St. Louis University School of Medicine, 1325 South Grand Boulevard, St. Louis 4, Missouri. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by1 Clinical EnzymologyCritical evaluation of pancreatic function testsEffect of pentaerythritol tetranitrate (PETN) on the positive prostigmin-morphine diastase responseTHE DIAGNOSIS OF CHRONIC PANCREATIC INSUFFICIENCY: WITH SPECIAL REFERENCE TO THE SECRETIN TESTProlonged hyperamylasemia following acute pancreatitisThe Pancreas. III 1 February 1963Volume 58, Issue 2Page: 229-234KeywordsChemical analysisFatsHospitalizationsIngestionMedical servicesMetabolic disordersPancreatic cancerPancreatic diseasesQuantitative analysisSecretin ePublished: 1 December 2008 Issue Published: 1 February 1963 PDF downloadLoading ...