tbuckley/cabot-search huggingface dataset:
990-53 Effects on Cardiovascular End Points and Psychological Variables of Metoprolol and Verapamil in Patients with Stable Angina Pectoris — The Angina Prognosis Study in Stockholm (APSIS)
Authors: Nina Rehnqvist, Paul Hjemdahl, Ewa Billing, Inge Björkander, Sven V. Eriksson, Lennart Forslund, Claes Held, Per Näsman, N. Håkan Wallén
Journal: Journal of the American College of Cardiology (1995)
Crisis in our schools: survey of sanitation facilities in schools in Bloomsbury health district.
Authors: R K Jewkes, B H O'Connor
Journal: BMJ (1990)

OBJECTIVE--To survey sanitation facilities in schools in Bloomsbury health district. DESIGN--Postal questionnaire. SETTING--Inner London health district. PARTICIPANTS--School nurses. RESULTS--16 of 17 school nurses responded (37 of 41 schools). Fifteen schools did not have the minimum number of toilets and hand basins established in the Education (School Premises) Regulations 1981. In two schools toilets were kept locked for most of the day. In 10 schools toilet paper was not always available, and three of five secondary schools did not have disposal units for sanitary towels in the girls9 toilet areas. In 18 of the schools the toilets were not kept adequately clean. CONCLUSIONS--These conditions raise serious questions about environmental health, with the potential for the spread of infectious diseases, and undermine attempts to teach children basic hygiene. Health professionals have an important role in assessing health and safety standards in schools and ensuring that necessary improvements are made.
Abstract 4353: Cycloxygenase-2 inhibitor regulates p73 isoform expression pattern, inhibit growth, and induce apoptosis in NHL cell line model with 1p36 chromosomal disruption.
Authors: Hesham M. Hassan, Michelle Varney, Shantaram S. Joshi, Rakesh K. Singh, Bhavana J. Dave
Journal: Cancer Research (2013)

Abstract Diclofenac is a cycloxynase-2 (COX-2) inhibitor that is used in clinics as an analgesic anti-inflammatory drug and has been shown to increase TP73 gene signature in multiple tumor cell lines. TP73, a gene at 1p36 locus, is controlled by a balance between two isoforms with opposing functions, the full length TAp73 protein (pro-apoptotic) and the NH2-terminally truncated ΔNp73 protein (anti-apoptotic through antagonizing both TAp73 and p53). Our previous work has shown a differential ΔNp73 up-regulation among NHL cases with 1p36 chromosomal disruption correlates with decreased apoptosis, increased cellular proliferation and increased angiogenesis. Modulation of ΔNp73:TAp73 ratio using TAp73 expression vector in Granta-519 (NHL cell line model that harbor disrupted 1p36 and express high levels of ΔNp73) resulted in growth inhibition and increased response to chemotherapy. In this study, we hypothesized that diclofenac treatment will modulate the expression profile of p73 isoforms and alter the behavior of the NHL cells with 1p36 disruption. Diclofenac treatment of Granta-519 cells resulted in a decrease in ΔNp73, increase in TAp73 mRNA expression. MTT assay showed a concentration- and duration-dependent cell growth inhibition. Decreased expression of the proliferation marker ki-67 and cell cycle arrest as indicated by flow cytometric cell cycle analysis; were evident following diclofenac treatment. Furthermore, Annexin-V-Flous flow cytometric analysis showed increased number of apoptotic cells that was associated with increased cleaved caspase-3 following diclofenec treatment. Moreover, pro-apoptotic target genes expression was induced by diclofenac treatment including p21, PUMA, NOXA, and BIM. Next we tested the effect of diclofenac treatment on standard CHOP-resistant Granta-519 sub-clones, that resulted in down-regulation of ΔNp73 mRNA expression and a significant dose-dependent growth inhibitory effect. Together, our data demonstrate that diclofenac treatment caused p73 isoforms reconstitution (↑TAp73 and/or ↓ΔNp73), inhibited growth of NHL cells with 1p36 abnormality and highlights the potential of diclofenac as a potential new adjuvant therapy in NHL with disrupted TP73 gene region. Citation Format: Hesham M. Hassan, Michelle Varney, Shantaram S. Joshi, Rakesh K. Singh, Bhavana J. Dave. Cycloxygenase-2 inhibitor regulates p73 isoform expression pattern, inhibit growth, and induce apoptosis in NHL cell line model with 1p36 chromosomal disruption. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4353. doi:10.1158/1538-7445.AM2013-4353
Drug Abuse Pandemic
Authors: George R. Edison
Journal: JAMA (1971)

To the Editor.—  I was amazed and chagrined at the EDITORIAL Drug Abuse: Pandemic, ( 214 :2327, 1970), which correctly called for an epidemiological approach, but dangerously and naively suggested that physicians become allies of the police by extracting and reporting information about drug pushers. It was with relief and gratitude that I read the EDITORIAL opposing this suggestion on sound ethical and therapeutic grounds ( 215 :1147, 1971).  There is also a practical reason for physicians to avoid this course: it would do no good. The drug-using host is not passively assaulted by the agent as in infectious disease. He most often actively seeks out the pusher, who may be merely filling a market-place need. Pushers cannot be identified, revealed, and removed fast enough to make a significant dent in the problem, as the abysmal failure of the Bureau of Narcotics and Dangerous Drugs over the years has demonstrated.  The epidemiology
Medical Roads Lead to New Hospital in Rome
Authors: Marsha F. Goldsmith
Journal: JAMA (1991)

ON THE OUTSKIRTS of Rome, three starkly modern buildings house a comprehensive medical facility whose concept and operation contrast as much with the usual public-sector Italian health care as the sleek architecture does with the antiquities of the city center. Rome American Hospital was opened as a profit-making venture by a group of Italian investors in May 1990, because of what Charles W. Neumann, an American and its chief executive officer, calls "the pressing demand for private health care in Italy." "It's ironic, isn't it?" Neumann asks. "Every European country that has a very large national health care commitment is looking for ways to reduce that commitment or shift it a bit more to the private sector. And in the United States, you're looking at just the opposite." Neumann was managing director of the European division of the Hospital Corporation of America Inc, which planned the Rome facility then turned
Cellular delivery of polynucleotides by cationic cyclodextrin polyrotaxanes
Authors: Prajakta Dandekar, Ratnesh Jain, Manuel Keil, Brigitta Loretz, Leon Muijs, Marc Schneider, Dagmar Auerbach, Gregor Jung, Claus-Michael Lehr, Gerhard Wenz
Journal: Journal of Controlled Release (2012)
Bone density and milk Consider fat as well as calcium intake Consider fat as well as calcium intake
Authors: K Seppa, A Avenell, D W Purdie, R E Thomas, D J Torgerson, D M Reid
Journal: BMJ (1994)

EDITOR, - Sean Murphy and colleagues concluded that milk consumption should be encouraged during childhood and adolescence to prevent osteoporotic fractures in later life.1 This, however, prompts several questions. Firstly, the subjects in the authors' study were asked to categorise their milk consumption without estimating their past total calcium intake. It is known that many subjects who do not drink milk consume other dairy products (cheese and ice cream). Secondly, the subjects had to recall their milk consumption up to age 25, which was a long time before the study (50 years for the 74 year old woman). It could as well be concluded that good memory makes strong bones or vice versa.

If the results are reliable they lead to an interesting speculation. It is known that calcium supplementation increases bone mass in childhood.2 This does not occur later in life. Might calcium, or some other agent in dairy products, affect the developing bone in a way that later in life allows calcium intake and maintains high mineral density?

I strongly disagree with the public health implications cited by Murphy and colleagues. Dietary habits are learnt in childhood and adolescence and commonly …
Epigenetic reprogramming modulates malignant properties of human liver cancer
Authors: Chiara Raggi, Valentina M. Factor, Daekwan Seo, Agnes Holczbauer, Matthew C. Gillen, Jens U. Marquardt, Jesper B. Andersen, Marian Durkin, Snorri S. Thorgeirsson
Journal: Hepatology (2014)

Reversal of DNA hypermethylation and associated gene silencing is an emerging cancer therapy approach. Here we addressed the impact of epigenetic alterations and cellular context on functional and transcriptional reprogramming of hepatocellular carcinoma (HCC) cells. Our strategy employed a 3-day treatment of established and primary human HCC-derived cell lines grown as a monolayer at various cell densities with the DNMT1 inhibitor zebularine (ZEB) followed by a 3D culture to identify cells endowed with self-renewal potential. Differences in self-renewal, gene expression, tumorigenicity, and metastatic potential of spheres at generations G1-G5 were examined. Transient ZEB exposure produced differential cell density-dependent responses. In cells grown at low density, ZEB caused a remarkable increase in self-renewal and tumorigenicity associated with long-lasting gene expression changes characterized by a stable overexpression of cancer stem cell-related and key epithelial-mesenchymal transition genes. These effects persisted after restoration of DNMT1 expression. In contrast, at high cell density, ZEB caused a gradual decrease in self-renewal and tumorigenicty, and up-regulation of apoptosis- and differentiation-related genes. A permanent reduction of DNMT1 protein using short hairpin RNA (shRNA)-mediated DNMT1 silencing rendered HCC cells insensitive both to cell density and ZEB effects. Similarly, WRL68 and HepG2 hepatoblastoma cells expressing low DNMT1 basal levels also possessed a high self-renewal, irrespective of cell density or ZEB exposure. Spheres formed by low-density cells treated with ZEB or sh DNMT1 displayed a high molecular similarity which was sustained through consecutive generations, confirming the essential role of DNMT1 depletion in the enhancement of cancer stem cell properties. Conclusion : These results identify DNA methylation as a key epigenetic regulatory mechanism determining the pool of cancer stem cells in liver cancer and possibly other solid tumors. (Hepatology 2014;59:2251–2262)
Perihepatitis Associated With Salpingitis in Adolescents
Authors: Iris F. Litt
Journal: JAMA (1978)

Perihepatitis, one manifestation of complicated gonorrhea, is infrequently diagnosed and reported. This study was undertaken to examine the incidence of gonococcal perihepatitis in adolescents as well as to study the effect, if any, of this condition on tests of liver function. Accordingly, the records of 137 adolescents with salpingitis were evaluated. Right upper quadrant tenderness or hepatic enlargement was noted in 27, while amino transferase level elevations were observed in 19 of the 59 in whom these tests were performed. All findings resolved promptly following initiation of intravenous penicillin therapy. The observation of hepatic dysfunction in 27% of these adolescents suggests that perihepatitis occurs more frequently than reported in adults and should be considered in the evaluation of the conditions of adolescents with salpingitis or upper abdominal tenderness.
264 INTENSIFIED DOSES OF PEGINTERFERON ALFA-2A AND/OR RIBAVIRIN ARE ASSOCIATED WITH HIGHER RATES OF SVR AND LOWER RELAPSE RATES AMONG PATIENTS WITH METABOLIC SYNDROME
Authors: S.A. Harrison, M.L. Shiffman, M. Rodriguez-Torres, D. Abdurakhmanov, G.F. Silva, C. Stanciu, W. Mazur, S.V. Feinman, C. Moreno, M. McKenna, D. Messinger, A. Teitz, K.R. Reddy
Journal: Journal of Hepatology (2010)
CD7‐positive acute leukemia lacking T cell receptor gene rearrangements and terminal deoxynucleotidyl transferase expression suggesting pre‐T cell origin
Authors: James C. Jacobs, Ann Rearden
Journal: American Journal of Hematology (1989)

Abstract In this report, we describe a case of acute leukemia possessing a unique immunophenotype. Leukemic cells isolated from peripheral blood were analyzed by automated fluorescence‐activated flow cytometry. They demonstrated the following antigen pattern: CD7+, CD38+, transferrin receptor+, HLA‐DR+, common ALL antigen (CALLA)‐, and terminal deoxynucleotidyl transferase (TdT)‐. No expression of B cell or myeloid antigens was observed. The observed antigen pattern suggests a pre‐T cell origin. In addition, the tumor cells contained germline T cell receptor beta (T β ) and gamma (T ± ) chain genes, and a germline immunoglobulin heavy chain (J H ) gene. These findings support the concept that pre‐T cell leukemias may demonstrate germline T β and T ± genes as well as lack TdT expression. In addition, our results suggest that CD7 expression may be one of the earliest events in T cell differentiation, occurring prior to both T β and T ± gene rearrangements, and TdT expression.
The induction by topical minoxidil of increased fenestration in the perifollicular capillary wall
Authors: None SAKITA, None KAGOURA, None TOYODA, None MOROHASHI
Journal: British Journal of Dermatology (1999)

We report the induction by topical minoxidil of increased fenestration in the perifollicular capillary wall. Male 30-day-old Wistar rats were divided into two groups, i.e. an experimental group which received 4% minoxidil solution topically on the dorsal skin, and a control group which received only vehicle solution topically. Using transmission electron microscopy, follicular and subepidermal capillaries and dermal fibres were compared between both groups. There were no obvious differences in subepidermal capillaries or dermal fibres between the two groups. However, topically applied minoxidil increased fenestration in follicular capillary walls around anagen hair bulbs.
Sentence comprehension in Broca's aphasia: A critique of the evidence
Authors: Rita Sloan Berndt
Journal: Behavioral and Brain Sciences (2000)

The argument that Broca's area is preferentially involved in specific syntactic operations is based on a strong assertion regarding patterns of sentence comprehension found among patients with Broca's aphasia. This assertion is shown to be largely inconsistent with the available evidence from published studies, which indicates that only a subgroup of Broca patients demonstrate the target pattern.
Use individual event rate adjustment for follow up time
Authors: K. Laitinen
Journal: BMJ (1995)

no hann and John Stuart Mill's libertarian philosophy of individual sovereignty and responsibility,4 so that sexual health is regarded as a basic human right.It emphasises the inseparability of physical and mental health in any holistic consideration of a person's sexual wellbeing.In this form it could be construed that the goal of sexual health is difficult or impossible to attain, given human fallibility.Previous definitions have been criticised as being applicable only to Western or European societies.Yet whenever choice is limited-be it by economic necessity (market forces), personal threat, societal norm, govern- ment legislation, religious edict, or other cultural pressures-both physical and mental aspects of sexual health suffer greatly because people are coerced into sex against their will.Indeed, the highest rates of sexually transmissible diseases and other reproductive morbidity occur where women and their rights are least valued or respected.The need for an integrated approach to sexual health and its medical care is not a sudden, recent development but one that has been obvious to a minority of concerned clinicians and educators for at least a generation.This definition further strengthens the philosophical basis of destigma- tised, holistic sexual health care, which integrates the promotion of sexual health with the provision of services for its maintenance.'5
Will Pass/Fail Pass?
Authors: Daniel D. Federman
Journal: New England Journal of Medicine (1978)

Attempts to correlate performance in medical school with the student's subsequent quality as a clinician have been dismally frustrating. In a comprehensive review of such studies, Wingard and Williamson found no definite relation between physicians' medical-school records and their later quality of clinical care.1 It is therefore especially interesting to learn that not ranking students has a measurable relation to the quality of their performance as residents.Moss et al., writing in this issue of the Journal, reasoned that carefully documented evaluations of house-staff performance might provide a retrospective test of the system of grading used in medical school. . . .
Abstract LB-400: The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients
Authors: Zemin Zhang
Journal: Cancer Research (2012)

Abstract Hepatitis B virus (HBV) infection is a leading risk factor for hepatocellular carcinoma (HCC). HBV integration into the host genome has been reported but its scale, impact and contribution to HCC development is not clear. Here, we sequenced the tumor and nontumor genomes (&amp;gt;80X coverage) and transcriptomes of four HCC patients and identified 255 HBV integration sites. Increased sequencing to 240X coverage revealed a proportionally higher number of integration sites. Clonal expansion of HBV-integrated hepatocytes was found specifically in tumor samples. We observe a diverse collection of genomic perturbations near viral integration sites, including direct gene disruption, viral promoter-driven human transcription, viral-human transcript fusion and DNA copy number alteration. Thus, we report the most comprehensive characterization of HBV integration in hepatocellular carcinoma patients. Such widespread random viral integration will likely increase carcinogenic opportunities in HBV-infected individuals. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-400. doi:1538-7445.AM2012-LB-400
1150-152 Utility of intracardiac echocardiography to guide radiofrequency catheter ablation of ventricular tachycardia of different etiologies
Authors: Monique R.M Jongbloed, Jeroen J Bax, Philippine Kies, Alida E Borger van der Burg, Katja Zeppenfeld, Ernst E van der Wall, Martin J Schalij
Journal: Journal of the American College of Cardiology (2004)
The Chronic Fatigue Syndrome
Authors: Charles W. Lapp, Paul R. Cheney
Journal: Annals of Internal Medicine (1995)

Letters1 July 1995The Chronic Fatigue SyndromeCharles W. Lapp, MD and Paul R. Cheney, MD, PhDCharles W. Lapp, MDThe Cheney Clinic; Charlotte, NC 28210Search for more papers by this author and Paul R. Cheney, MD, PhDThe Cheney Clinic; Charlotte, NC 28210Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-1-199507010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The development of a practical case definition for the chronic fatigue syndrome has been extremely difficult because of the protean symptoms of the disorder and the lack of a specific diagnostic test or pathognomonic sign. In the absence of such a gold standard for defining the disorder, Fukuda and the International Chronic Fatigue Study Group (at the Centers for Disease Control and Prevention) [1] have proposed a case definition for the syndrome. The authors state, however, that this definition is specifically designed for research purposes only, leaving practitioners and others without a satisfactory diagnostic tool.We present ...REFERENCE1. Fukuda K, Strauss SE, Hickie I, Sharpe MC, Dobbins JG, Komoroff A, and the International Chronic Fatigue Syndrome Study Group. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med. 1994; 121:953-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: The Cheney Clinic; Charlotte, NC 28210 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA Pediatric Case Definition for Myalgic Encephalomyelitis and Chronic Fatigue SyndromeChronisches Müdigkeits- und Fibromyalgiesyndrom — Manifestation einer generalisierten neuroregulativen Funktionsstörung?Cognitive functioning with chronic fatigue 1 July 1995Volume 123, Issue 1Page: 74-76KeywordsChronic fatigue syndromeFatigueResearch designSigns and symptoms Issue Published: 1 July 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Assessment of Audit Methodologies for Bias Evaluation of Tumor Progression in Oncology Clinical Trials
Authors: Jenny J. Zhang, Lijun Zhang, Huanyu Chen, Anthony J. Murgo, Lori E. Dodd, Richard Pazdur, Rajeshwari Sridhara
Journal: Clinical Cancer Research (2013)

Abstract As progression-free survival (PFS) has become increasingly used as the primary endpoint in oncology phase III trials, the U.S. Food and Drug Administration (FDA) has generally required a complete-case blinded independent central review (BICR) of PFS to assess and reduce potential bias in the investigator or local site evaluation. However, recent publications and FDA analyses have shown a high correlation between local site evaluation and BICR assessments of the PFS treatment effect, which questions whether complete-case BICR is necessary. One potential alternative is to use BICR as an audit tool to detect evaluation bias in the local site evaluation. In this article, the performance characteristics of two audit methods proposed in the literature are evaluated on 26 prospective, randomized phase III registration trials in nonhematologic malignancies. The results support that a BICR audit to assess potential bias in the local site evaluation is a feasible approach. However, implementation and logistical challenges need further consideration and discussion. Clin Cancer Res; 19(10); 2637–45. ©2013 AACR.
Risk Factors for Rifampin Mono-resistant Tuberculosis
Authors: RENÉE RIDZON, CYNTHIA G. WHITNEY, MATTHEW T. McKENNA, JEFFERY P. TAYLOR, SUSAN H. ASHKAR, ANNETTE T. NITTA, SYDNEY M. HARVEY, SARAH VALWAY, CHARLES WOODLEY, ROBERT COOKSEY, IDA M. ONORATO
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Use of rifampin is required for short-course treatment regimens for tuberculosis. Tuberculosis caused by isolates of M. tuberculosis with resistance to rifampin and susceptibility to isoniazid is unusual, but it has been recognized through surveillance. Patients with tuberculosis (cases) with rifampin mono-resistance were compared with HIV-matched controls with tuberculosis caused by a drug-susceptible isolate. A total of 77 cases of rifampin mono-resistant tuberculosis were identified in this multicenter study. Three were determined to be laboratory contaminants, and 10 cases had an epidemiologic link to a case with rifampin mono-resistant tuberculosis, suggesting primary acquisition of rifampin-resistant isolates. Of the remaining 64 cases and 126 controls, there was no difference between cases and controls with regard to age, sex, race, foreign birth, homelessness, or history of incarceration. Cases were more likely to have a history of prior tuberculosis than were controls. Of the 38 cases and 74 controls with HIV infection, there was no difference between cases and controls with regard to age, sex, race, foreign birth, homelessness, history of incarceration, or prior tuberculosis. Cases were more likely to have histories of diarrhea, rifabutin use, or antifungal therapy. Laboratory analysis of available isolates showed that there was no evidence of spread of a single clone of M. tuberculosis. Further studies are needed to identify the causes of the development of rifampin resistance in HIV-infected persons with tuberculosis and to develop strategies to prevent its emergence.