tbuckley/cabot-search huggingface dataset:
The importance of serum creatine phosphokinase level in the early diagnosis, and as a prognostic factor, of Vibrio vulnificus infection
Authors: J. Nakafusa, N. Misago, Y. Miura, M. Kayaba, T. Tanaka, Y. Narisawa
Journal: British Journal of Dermatology (2001)

Journal Article The importance of serum creatine phosphokinase level in the early diagnosis, and as a prognostic factor, of Vibrio vulnificus infection Get access J. Nakafusa, J. Nakafusa Division of Dermatology, Department of Internal Medicine, Saga Medical School, 5‐1‐1 Nabeshima, Saga City 849‐8501, Japan Search for other works by this author on: Oxford Academic Google Scholar N. Misago, N. Misago Division of Dermatology, Department of Internal Medicine, Saga Medical School, 5‐1‐1 Nabeshima, Saga City 849‐8501, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Miura, Y. Miura Division of Dermatology, Department of Internal Medicine, Saga Medical School, 5‐1‐1 Nabeshima, Saga City 849‐8501, Japan Search for other works by this author on: Oxford Academic Google Scholar M. Kayaba, M. Kayaba Division of Dermatology, Department of Internal Medicine, Saga Medical School, 5‐1‐1 Nabeshima, Saga City 849‐8501, Japan Search for other works by this author on: Oxford Academic Google Scholar T. Tanaka, T. Tanaka Division of Dermatology, Department of Internal Medicine, Saga Medical School, 5‐1‐1 Nabeshima, Saga City 849‐8501, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Narisawa Y. Narisawa Division of Dermatology, Department of Internal Medicine, Saga Medical School, 5‐1‐1 Nabeshima, Saga City 849‐8501, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 2, 1 August 2001, Pages 280–284, https://doi.org/10.1046/j.1365-2133.2001.04347.x Published: 01 August 2001
Book Review Family Medicine: Principles and practice Fifth edition. Edited by Robert B. Taylor, with Alan K. David, Thomas A. Johnson, Jr., D. Melessa Phillips, and Joseph E. Scherger. 1191 pp., illustrated. New York, Springer-Verlag, 1997. $130. 0-387-94958-5
Authors: David N. Little
Journal: New England Journal of Medicine (1998)
P221 VIROLOGY ANALYSES OF SIMEPREVIR IN PHASE 2B AND 3 STUDIES
Authors: O. Lenz, T. Verbinnen, B. Fevery, L. Tambuyzer, L. Vijgen, M. Peeters, A. Buelens, M. Beumont-Mauviel, G. Picchio, S. de Meyer
Journal: Journal of Hepatology (2014)
From the authors
Authors: Y. Lacasse, F. Maltais
Journal: European Respiratory Journal (2005)

I. Garcia-Talavera's reaction to the results of our trial of ambulatory oxygen (AO) in oxygen-dependent chronic obstructive pulmonary disease (COPD) is of no surprise to us. We realise that our findings, i.e. that as-needed AO provided for a period of 3 months had no effect on quality of life and walked distance 1, are against the stream of current guidelines ( i.e. that active patients receiving long-term oxygen therapy should have both stationary and mobile systems of oxygen delivery) 2 …
Swallowing Function in Schizophrenics
Authors: Allen E. Hussar, David G. Bragg
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 August 1970Swallowing Function in SchizophrenicsALLEN E. HUSSAR, M.D., DAVID G. BRAGG, M.D.ALLEN E. HUSSAR, M.D., DAVID G. BRAGG, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-2-343 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent editorial note on "Esophageal Function in Diabetes Mellitus" (Ann Intern Med 72:281-282, 1970), Drs. Goyal and Spiro briefly summarized esophageal disorders seen in various conditions. To this we should like to add the findings of our recent study on the swallowing function in chronic schizophrenic patients (1).Since the cooperation necessary for manometric studies could not be expected in a psychotic group of patients, cineradiographic method was applied. The investigation resulted in two significant findings: [1] Almost half of the schizophrenic patients showed various degrees of cineradiographic abnormalities; and [2] chlorpromazine medication had no...Reference1. HUSSARBRAGG AD: The effect of chlorpromazine on the swallowing function in chronic schizophrenic patients. Amer J Psychiat 126:570-573, 1969 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDysphagia is a Common and Serious Problem for Adults with Mental Illness: A Systematic Review 1 August 1970Volume 73, Issue 2Page: 343-344KeywordsChlorpromazineDiabetes mellitusSwallowing Issue Published: 1 August 1970 PDF DownloadLoading ...
The Editor, 'The British Journal of Dermatology'. Mycobacterium ulcerans infection
Authors: Jean C. Tolhurst, Glen Buckle
Journal: British Journal of Dermatology (1967)

Journal Article The Editor, ‘The British Journal of Dermatology’. Mycobacterium ulcerans infection Get access Jean C. Tolhurst, Jean C. Tolhurst Alfred Hospital Commercial Rd., Prahran, S.1, Victoria, Australia Search for other works by this author on: Oxford Academic Google Scholar Glen Buckle Glen Buckle Alfred Hospital Commercial Rd., Prahran, S.1, Victoria, Australia Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 79, Issue 6, 1 June 1967, Page 366, https://doi.org/10.1111/j.1365-2133.1967.tb11510.x Published: 01 June 1967
Regulation of G-protein alpha i2 subunit expression by oxidized low-density lipoprotein.
Authors: J K Liao, S L Clark
Journal: Journal of Clinical Investigation (1995)

Oxidized low-density lipoprotein (LDL) inhibits signalling pathways mediated by pertussis toxin-sensitive guanine nucleotide-binding proteins (Gi proteins). To determine whether this inhibition is due to altered G protein alpha i subunit expression, mRNA and protein levels of alpha i isoforms were assessed in bovine aortic endothelial cells treated with oxidized LDL (0-100 micrograms/ml, 0-72 h). Oxidized LDL did not affect the expression of alpha i3, but did cause time- and concentration-dependent decrease in alpha i2 mRNA and protein resulting in a 3.2- and 3.5-fold reduction, respectively, after 72 h. This decrease in alpha i2 coincided with a 86% decrease in alpha i2 GTPase activity. Nuclear run-off studies did not show any significant effect of oxidized LDL on alpha i2 or alpha i3 transcription. In the presence of actinomycin D, oxidized LDL shortened the t1/2 of alpha i2 mRNA from 16 h to 8 h which was attenuated by cycloheximide. In addition, pulse-chase labelling with [35S]methionine revealed that oxidized LDL reduced the t1/2 of alpha i2 protein from 27 to 14 h. Our results indicate that oxidized LDL can modulate receptor-Gi coupling by downregulating the expression of alpha i2, but not alpha i3. The mechanism involves both mRNA destabilization and protein degradation.
Children's health, susceptibility, and regulatory approaches to reducing risks from chemical carcinogens.
Authors: G Charnley, R M Putzrath
Journal: Environmental Health Perspectives (2001)

Risk-based regulation of chemical exposures from the environment generally relies on assumptions about the extent of people's susceptibility to chemically induced diseases. Those assumptions are intended to be health-protective; that is, they err on the side of overstating susceptibility. Recent concern about children's special susceptibilities has led to proposals that would make risk-based regulations one-tenth more stringent, unless data are available to refute the assumption that children are more susceptible than adults. In this paper we highlight some of the questions that should be addressed in the context of risk assessment to determine whether such increased stringency would accomplish the desired result of improving children's health. In particular, characterizing benefits of greater stringency requires more information about dose-response relationships than is currently available. Lowering regulatory levels has attendant costs but may not achieve benefits, for example, if the previous level were already below an actual or practical threshold. Without an ability to understand the potential benefit (or lack thereof) of the additional stringency, an appropriate consideration of benefits and costs is not possible.
<i>Para-</i> and <i>Ortho</i> -Substitutions Are Key Determinants of Polybrominated Diphenyl Ether Activity toward Ryanodine Receptors and Neurotoxicity
Authors: Kyung Ho Kim, Diptiman D. Bose, Atefeh Ghogha, Joyce Riehl, Rui Zhang, Christopher D. Barnhart, Pamela J. Lein, Isaac N. Pessah
Journal: Environmental Health Perspectives (2010)

Polybrominated diphenyl ethers (PBDEs) are widely used flame retardants that bioaccumulate in human tissues. Their neurotoxicity involves dysregulation of calcium ion (Ca(2+))signaling; however, specific mechanisms have yet to be defined.We aimed to define the structure-activity relationship (SAR) for PBDEs and their metabolites toward ryanodine receptors type 1 (RyR1) and type 2 (RyR2) and to determine whether it predicts neurotoxicity.We analyzed [3H]ryanodine binding, microsomal Ca(2+) fluxes, cellular measurements of Ca(2+) homeostasis, and neurotoxicity to define mechanisms and specificity of PBDE-mediated Ca(2+) dysregulation.PBDEs possessing two ortho-bromine substituents and lacking at least one para-bromine substituent (e.g., BDE-49) activate RyR1 and RyR2 with greater efficacy than corresponding congeners with two para-bromine substitutions (e.g., BDE-47). Addition of a methoxy group in the free para position reduces the activity of parent PBDEs. The hydroxylated BDEs 6-OH-BDE-47 and 4´-OH-BDE-49 are biphasic RyR modulators. Pretreatment of HEK293 cells (derived from human embryonic kidney cells) expressing either RyR1 or RyR2 with BDE-49 (250 nM) sensitized Ca2+ flux triggered by RyR agonists, whereas BDE-47 (250 nM) had negligible activity. The divergent activity of BDE-49, BDE-47, and 6-OH-BDE-47 toward RyRs predicted neurotoxicity in cultures of cortical neurons.We found that PBDEs are potent modulators of RyR1 and RyR2. A stringent SAR at the ortho and para position determined whether a congener enhanced, inhibited, or exerted nonmonotonic actions toward RyRs. These results identify a convergent molecular target of PBDEs previously identified for noncoplanar polychlorinated biphenyls (PCBs) that predicts their cellular neurotoxicity and therefore could be a useful tool in risk assessment of PBDEs and related compounds.
Prognostic Value of Renal Vein and Inferior Vena Cava Involvement in Renal Cell Carcinoma
Authors: Bernd Wagner, Jean-Jacques Patard, Arnaud Méjean, Karim Bensalah, Grégory Verhoest, Richard Zigeuner, Vincenzo Ficarra, Jacques Tostain, Peter Mulders, Denis Chautard, Jean-Luc Descotes, Alexandre de la Taille, Laurent Salomon, Tommaso Prayer-Galetti, Luca Cindolo, Antoine Valéri, Nicolas Meyer, Didier Jacqmin, Hervé Lang
Journal: European Urology (2008)
Downhill varices resulting from giant intrathoracic goiter
Authors: K. Mönkemüller, D. Poppen, K. Feldmann, L. Ulbricht
Journal: Endoscopy (2010)

An 82-year-old man was admitted to the hospital because of substernal chest pain, dyspnea, and occasional dysphagia to solids. His past medical history was remarkable for diabetes mellitus type II, hyperlipidemia, and Parkinson’s disease. On physical examination he appeared frail but with no apparent distress. Examination of the neck showed no masses, stridor or jugular venous distension. Heart examination disclosed a regular rate and rhythm; however a 2/6 systolic ejection murmur was apparent. The lung and abdominal examinations were unremarkable, and laboratory data were within reference ranges. Myocardial ischemia was ruled out. Because of the intermittent dysphagia an esophagogastroduodenoscopy (EGD) was performed, which revealed multiple submucosal veins in the upper esophagus, consistent with downhill varices ([Fig. 1]). Computed tomography (CT) of the chest found a large retrosternal goiter extending into the mediastinum ([Fig. 2]). This was not treated as there was no evidence of bleeding or bleeding stigmata. The patient was offered surgical resection of the large goiter. However, due to his advanced age he preferred to be treated conservatively.
Hepatitis C Virus Type 1b (II) Infection in France and Italy
Authors: Jean-Baptiste Nousbaum
Journal: Annals of Internal Medicine (1995)

Objective: To analyze the distribution of hepatitis C virus (HCV) genotypes among patients positive for antibody to HCV (anti-HCV) according to age, severity of liver disease, and duration of infection; to investigate the influence of HCV genotypes on response to interferon-α therapy; and to study HCV viremia levels in relation to genotypes and severity of liver disease. Design: Cross-sectional study. Setting: 3 university hospitals and 2 research units. Patients: 3 groups of French and Italian patients with chronic HCV infection and detectable serum HCV RNA: Group 1 included 35 patients with hepatocellular carcinoma; group 2, 71 patients with cirrhosis who did not have hepatocellular carcinoma; and group 3, 114 patients with chronic active hepatitis. 106 of the patients with chronic hepatitis or cirrhosis were treated with interferon-α (3 MU subcutaneously 3 times/wk for ≥ 6 months). Measurements: Genotyping by polymerase chain reaction with capsid-specific primers; serum HCV RNA by branched DNA (bDNA) signal amplification. Results: Hepatitis C virus genotype 1b (II) was the most prevalent genotype (61.8%). In a univariate analysis, it was associated with older age (<40 years, 47.4%; ≥ 60 years, 80.4%; P = 0.001), longer duration of disease (≤ 10 years, 40.4%; ≥ 20 years, 86.7%; P = 0.005), and cirrhosis with or without hepatocellular carcinoma (78.4% compared with 53.8% for chronic hepatitis; P < 0.001). Viremia levels did not differ between patients infected with HCV type 1b (II) and those infected with other HCV genotypes. Patients with HCV type 1b (II) responded to interferon-α therapy significantly less than did patients with other HCV genotypes (P = 0.01). In a multivariate analysis, age and cirrhosis were independently associated with HCV genotype 1b (II). Genotype and HCV viremia level were independent predictors of response to interferon-α therapy. Conclusions: The prevalence of HCV genotypes in French and Italian patients has been changing; the prevalence of HCV type 1b (II) infection has progressively decreased, although it still accounts for most HCV-related cirrhosis and hepatocellular carcinoma. High HCV viremia levels and HCV genotype type 1b (II) are independent predictors for poor response to interferon-α therapy and should be considered in the management of patients with HCV infection. For affiliations and current author addresses, see end of text. *For a listing of collaborators, see Appendix 2.
Surgery as a Human Experience: The Psychodynamics of Surgical Practice
Authors: Philip Thorek
Journal: JAMA (1960)

With the growing tendency of medical men to specialize, it is no longer possible for any practitioner to be all things to all patients, and the need for an interrelationship of surgical and psychiatric services becomes apparent. The authors of this extremely well-written book have delved deeply into the emotional problems of the surgical patient which can affect his recovery and adjustment to his altered condition. Reporting the results of a two-year study of 200 surgical patients selected at random, who were followed up for six months after their operations, the authors have produced a text which is illuminating to the surgeon, the general practitioner, and the patient himself. They have investigated preoperative and postoperative depressions, the reaction of patients with psychosomatic illness to operation, the influence of deep-seated emotional stress on recovery, the personality changes that can be expected after the patient has lost a body function or organ,
Intrarenal distribution of the colonic H,K-ATPase mRNA in rabbit
Authors: Géza Fejes-Tóth, Anikó Náray-Fejes-Tóth, Heino Velázquez
Journal: Kidney International (1999)

Evidence suggests that the colonic H,K-ATPase isoform is expressed in the kidney and that a mRNA species highly homologous to the rat and guinea pig HKalpha2 is expressed in the cortical collecting duct (CCD) of the rabbit. The goals of this study were to determine if this mRNA is the rabbit homologue of HKalpha2 or a novel isoform and to determine intrarenal distribution of the HKalpha2 mRNA in rabbit.5'-RACE and Dye Deoxy Terminator chemistry were used to determine the full-length sequence of the rabbit HKalpha2 mRNA. The intrarenal distribution of HKalpha2 mRNA was determined in microdissected nephron segments, connecting tubule (CNT), and CCD cells isolated by immunodissection, as well as in the three cell types of the CCD. Principal cells and alpha- and beta-intercalated cells were isolated by fluorescence-activated cell sorting. HKalpha2 mRNA levels were determined by quantitative reverse transcription-polymerase chain reaction (RT-PCR) or single-nephron RT-PCR (SN-RTPCR).The full-length sequence of the rabbit kidney HKalpha2 mRNA was determined. This transcript is identical to the one expressed in rabbit distal colon. In microdissected nephron segments, strong HKalpha2 amplicons were present in the CNT, CCD, and outer medullary collecting duct (OMCD), whereas no signal was detected in the proximal tubule, distal convoluted tubule, think ascending limb, and inner medullary collecting duct. Roughly comparable levels of HKalpha2 mRNA were present in all three CCD cell types, and the highest levels were observed in a subpopulation most likely corresponding to CNT cells.These results suggest that the HKalpha2 mRNA is expressed in rabbit collecting duct is identical in size and sequence to the one expressed in rabbit distal colon. HKalpha2 mRNA in the rabbit kidney is selectively expressed in the CNT, CCD, and OMCD, and all three collecting duct subtypes express its mRNA.
Disability after Critical Illness
Authors: Margaret Herridge, Jill I. Cameron
Journal: New England Journal of Medicine (2013)

Critical illness creates new neurocognitive and functional disabilities and further compromises preexisting organ dysfunction. These are truths borne out in multiple international studies.16 Recovery from severe illness is complex and relies on a fragile interdependence of adequate premorbid organ reserve, attentive care in the intensive care unit (ICU), timely and individualized rehabilitation, ongoing access to responsive health care professionals, and extensive personal and family resources. In short, getting better is difficult.In their seminal work from 1999, Hopkins and colleagues established that survivors of the acute respiratory distress syndrome (ARDS) had important decrements in multiple cognitive domains, and these . . .
Body Mass Index and Mortality Among Nonsmoking Older Persons
Authors: Tamara Harris
Journal: JAMA (1988)

The relationship of weight at age 65 years and subsequent mortality was examined in a population of 1723 nonsmokers who were followed up from one to 23 years (mean, 9.5 years) during the Framingham Heart Study. In sex-specific proportional hazards analyses, risks of mortality were increased for men and women at the high and low extremes of body mass index, even when accounting for potential effects of excess weight on serum cholesterol level, blood glucose level, and systolic blood pressure. For those at the lower extreme of body mass index, the relative risk of death was almost twice as high in the years immediately after age 65 years as in later follow-up, suggesting that the increased early death rate was due to disease that was already present. At the upper extreme, risk of death was twofold over the entire follow-up period for persons with body mass indexes at or above the 70th percentile at both 55 and 65 years of age. We conclude that, even when accounting for cardiovascular risk factors, being overweight is a serious health problem for older people, especially for those with long-standing weight problems.
AUTOTRANSPLANTATION OF A TOE FOR TRAUMATIC LOSS OF A FINGER
Authors: Joseph E. Fuld
Journal: JAMA (1926)

Nicoladoni<sup>1</sup>was the first to describe the autoplastic transplantation of a toe for the traumatic loss of a finger. He successfully performed and described an operation in which he replaced a thumb by transplanting the second toe. Since then very few cases of successful transplantation of toes to replace lost fingers have been reported. <h3>REPORT OF CASE</h3> G. S., a man, aged 30, while operating a bread-slicing machine, Sept. 18, 1925, accidentally amputated the distal third of the middle finger of his right hand. The wound being recent and clean, I considered this a favorable opportunity to attempt grafting a toe to replace the missing finger. The day following the injury, the patient was placed under ether, and after exceptional care of the surgical field, I made an incision at the level of the head of the fifth metatarsal bone, transversely across the dorsum of the small toe of
Migratory and Lymphoid-resident Dendritic Cells Cooperate in Murine Lymph Nodes for Efficient CD4 + T Cell Priming
Authors: E.J. Allenspach, M.P. Lemos, P.M. Porrett, L.A. Turka, T.M. Laufer
Journal: Journal of Allergy and Clinical Immunology (2009)
Beta-Interferon Therapy in Patients with Poor-Prognosis Kaposi Sarcoma Related to the Acquired Immunodeficiency Syndrome (AIDS)
Authors: Steven A. Miles
Journal: Annals of Internal Medicine (1990)

To study the efficacy of high doses of beta-ser-interferon (recombinant human 17-serine beta-interferon) in patients with human immunodeficiency virus (HIV) infection and Kaposi sarcoma.A nonrandomized, controlled trial of two high-dose regimens of beta-ser-interferon administered until tumor progression, toxicity, or an acquired immunodeficiency syndrome (AIDS)-defining opportunistic infection occurred.An AIDS treatment clinic at a tertiary care center.A sequential sample of 39 patients with biopsy-proven, AIDS-related Kaposi sarcoma were enrolled during a 2-year period. Thirty-eight patients were evaluable for response. Most patients (35 of 38) had one or more of the following clinical or laboratory predictors for a poor response to interferon therapy: HIV p24 antigenemia, low CD4 cell numbers, elevated beta 2-microglobulin levels, previous opportunistic infections, or previous systemic chemotherapy.Beta-ser-interferon was self-administered subcutaneously at home 5 days per week. The first 21 patients used 90 million IU/d, and the remainder used 180 million IU/d.Six patients (16%) had a major clinical response, and 15 (39%) had stable disease for prolonged periods. Toxicities were minimal; the major toxicity was a skin reaction at the injection site. The HIV p24 antigen level declined more than 50% in 8 of the 19 patients with initial values greater than 50 pg/mL. Antiretroviral activity and antitumor activity were seen only in patients with normal initial beta 2-microglobulin levels. Minimal changes were seen in CD4 and CD8 cell numbers. Only 1 patient had an opportunistic infection while on study, but five other patients developed infections after treatment was discontinued for an incidence of six opportunistic infections in 285 patient-observation months.The high doses of interferon did not improve the major response rate in patients with poor-prognosis, AIDS-related Kaposi sarcoma. There was, however, a suggestion of antiviral activity in patients with normal beta 2-microglobulin levels and a decrease in the expected incidence of opportunistic infections.