tbuckley/cabot-search huggingface dataset:
Calcitriol restores renovascular function in estrogen-deficient rats through downregulation of cyclooxygenase-2 and the thromboxane-prostanoid receptor
Authors: Jinghui Dong, Siu Ling Wong, Chi Wai Lau, Jian Liu, Yi-Xiang Wang, Zhen Dan He, Chi Fai Ng, Zhen Yu Chen, Xiaoqiang Yao, Aimin Xu, Xiaochen Ni, Hongyan Wang, Yu Huang
Journal: Kidney International (2013)
Erratum: Corrigendum: Nictation, a dispersal behavior of the nematode Caenorhabditis elegans, is regulated by IL2 neurons
Authors: Harksun Lee, Myung-kyu Choi, Daehan Lee, Hye-sung Kim, Hyejin Hwang, Heekyeong Kim, Sungsu Park, Young-ki Paik, Junho Lee
Journal: Nature Neuroscience (2013)
Real-time myocardial contrast echocardiography reveals microvessel recruitment soon after coronary occlusion
Authors: Fuminobu Ishikura, Kentaro Ohtani, Hideo Hirayama, Jyuri Okazaki, Yasushi Kashiwagi, Sachiko Yagura, Tsutomu Toshida, Akiko Iwata, Hiroyuki Kayano, Toshihiko Asanuma, Shintaro Beppu
Journal: Journal of the American College of Cardiology (2002)
Epimorphin promotes human hepatocellular carcinoma invasion and metastasis through activation of focal adhesion kinase/extracellular signal-regulated kinase/matrix metalloproteinase-9 axis
Authors: Ya-Li Jia, Lei Shi, Jun-Nian Zhou, Chun-Jiang Fu, Lin Chen, Hong-Feng Yuan, Yun-Fang Wang, Xin-Long Yan, Ying-Chen Xu, Quan Zeng, Wen Yue, Xue-Tao Pei
Journal: Hepatology (2011)

The high incidence rate of hepatocellular carcinoma (HCC) is mainly the result of frequent metastasis and tumor recurrence. Unfortunately, the underlying molecular mechanisms driving HCC metastasis are still not fully understood. It has been demonstrated that tumor stroma cells contribute to primary tumor growth and metastasis. Within the HCC environment, activated hepatic stellate cells (HSCs) can release a number of molecules and enhance cancer cell proliferation and invasiveness in a paracrine manner. Here, for the first time, we demonstrate that epimorphin (EPM; also called syntaxin-2), an extracellular protein, is strongly elevated in activated HSCs within tumor stroma. We show that knockdown of EPM expression in HSCs substantially abolishes their effects on cancer cell invasion and metastasis. Ectopic expression of EPM in HCC cancer cells enhances their invasiveness; we demonstrate that the cells expressing EPM have markedly increased metastasis potential. Furthermore, EPM-mediated invasion and metastasis of cancer cells is found to require up-regulation of matrix metalloproteinase-9 (MMP-9) through the activation of focal adhesion kinase (FAK)/extracellular signal-regulated kinase (ERK) axis.Our results show that EPM, secreted by activated HSCs within HCC stroma, promotes invasion and metastasis of cancer cells by activating MMP-9 expression through the FAK-ERK pathway.
Beds in the NHS
Authors: A M Pollock
Journal: BMJ (2000)

News p 463

January was a tough month for British health ministers, as a flu epidemic put the inadequacies of the NHS on the front page of most newspapers, but then it's been a tough two decades for patients and staff in the NHS. The political remedy for the chronic underfunding of the NHS has been perpetual revolution through reorganisation. Recent acute hospital and NHS service reconfigurations around Britain show how management and political reputations have been staked on exploiting the apparently bottomless pit of clinical productivity to fund investment. But judging by rising waiting lists, growing patient dissatisfaction, and low morale among staff, modernisation appears to be a recipe for reducing capacity and loss of service. A government inquiry has now provided the hard data to confirm this impression

The National Bed Inquiry, commissioned in 1998 by the Secretary of State for Health to test the hypothesis that bed closures had gone too far, was finally published last week in the form of a consultation document and supporting analysis.1 2 The consultation document, Shaping the future NHS: long term planning for hospital and related services , shows not only that is there is little scope for productivity gains but also that there is no spare capacity in the NHS.1 The …
RNA Aptamer-targeted Inhibition of NF-κB Suppresses Non-small Cell Lung Cancer Resistance to Doxorubicin
Authors: Jing Mi, Xiuwu Zhang, Zahid N Rabbani, Yingmiao Liu, Srinevas K Reddy, Zhen Su, Fawzia K Salahuddin, Kristi Viles, Paloma H Giangrande, Mark W Dewhirst, Bruce A Sullenger, Christopher D Kontos, Bryan M Clary
Journal: Molecular Therapy (2007)

Due to the prevalence of tumor chemoresistance, the clinical response of advanced non-small cell lung cancer (NSCLC) to chemotherapy is poor. We suppressed tumor resistance to doxorubicin (Dox) in A549 cells, a human NSCLC cell line, both in vitro and in vivo in a lung tumor xenograft model, using a novel adenoviral expression system to deliver an RNA aptamer (A-p50) that specifically inhibits nuclear factor-kappaB (NF-kappaB) activation. By achieving selective, targeted, and early inhibition of NF-kappaB activity, we demonstrate that NF-kappaB plays a critical role in Dox-induced chemoresistance by regulating genes involved in proliferation (Ki-67), response to DNA damage (GADD153), antiapoptosis (Bcl-XL), and pH regulation (CA9). This Dox-induced NF-kappaB activation and subsequent chemoresistance is dependent on expression of p53. We also demonstrate that NF-kappaB promotes angiogenesis in the presence of Dox via the hypoxia-inducible factor-1alpha/vascular endothelial growth factor (HIF-1alpha/VEGF) pathway, revealing a previously unknown mechanism of NSCLC resistance to Dox. These studies provide important insights into the mechanisms of Dox-induced chemoresistance, and they demonstrate a novel, effective, and clinically practical strategy for interfering with these processes.
Rationing in response to NHS deficits: rural patients are likely to be affected most
Authors: Sheena Asthana, Alex Gibson
Journal: BMJ (2005)

Rationing in response to NHS deficits: rural patients are likely to be affected most See News, p 1426Editor-News that pressing financial problems have caused NHS trusts in Suffolk to set new "thresholds" to treatments such as joint replacements reinforces concerns raised by a recent BMA survey of medical directors of trusts in which over a third of respondents anticipated reductions of key services in response to funding shortfalls. 1 2 What has hitherto escaped comment is how cuts in services are far more likely to be felt in some parts of the country than others.Deficits in the NHS are invariably presented as a problem of financial mismanagement, but the pattern of deficits shows that the current resource allocation model discriminates against particular communities.According to the recently published accounts for 2004-5, 3 89 out of 303 (30%) English primary care trusts ended the year in deficit.The table shows how 301 of these trusts are distributed accorded to fifths of deprivation and rurality.Primary care trusts serving populations that are in both the most rural and the least deprived fifth were most likely to be in financial difficulties.Seventeen of the 25 (68%) in this category were in deficit.These trusts received the lowest funding allocation per head (£995).By contrast, only 3% (one of 34) of the primary care trusts serving populations that are in both the most urban and the most deprived fifths failed to break even in 2004-5.These trusts received the highest funding allocations per head (£1405).This shows that poor financial management can at best only partly explain why some trusts are in deficit.The pattern of deficits implies that NHS funding provides insufficient resources for rural areas, for comparatively affluent areas, and, most particularly, for areas that are both rural and affluent.The risk is that such measures will result in NHS services being subject to a new postcode lottery, in which rural residents are more likely to lose out.
Organization of secondary lymphoid tissue and local IgE formation to <i>Staphylococcus aureus</i> enterotoxins in nasal polyp tissue
Authors: P. Gevaert, G. Holtappels, S. G. O. Johansson, C. Cuvelier, P. van Cauwenberge, C. Bachert
Journal: Allergy (2004)

Bilateral nasal polyposis (NP) is characterized by high concentrations of IgE in NP tissue, which show no relation to the atopic status. We aimed to study the relationship between systemic and local IgE formation, nasal carriage of Staphylococcus aureus and nasal polyposis.In serum and nasal tissue homogenates from 24 NP patients and 12 controls, we determined concentrations of total IgE and IgE antibodies to inhalant allergens and S. aureus enterotoxins (SAEs; A,B,C,D,E,TSST) by ImmunoCAP. Tissue cryosections were stained for CD3, CD20, CD38, CD23, FcepsilonRI, IgE and SEA/SEB.We demonstrated a higher incidence of S. aureus colonization (17/24) and IgE antibodies to SAEs in NP tissue (12/24) compared with controls (3/12 and 0/12, respectively). Total IgE and IgE antibodies in serum and NP tissue were dissociated because of local polyclonal IgE formation in NP tissue. Staining of NP tissue revealed follicular structures characterized by B and T cells, and lymphoid accumulations with diffuse plasma cell infiltration.We demonstrated the organization of secondary lymphoid tissue in polyp tissue and a polyclonal hyper-immunoglobulinemia E associated with the presence of IgE antibodies to SAEs, colonization with S. aureus, and tissue eosinophilia in a relevant subgroup of polyp patients.
Chromosome Abnormality in Offspring of LSD User
Authors: Lillian Y. Hsu
Journal: JAMA (1970)

Congenital abnormalities compatible with D<sub>1</sub>-trisomy occurred in a newborn girl whose parents had used lysergic acid diethylamide (LSD) prior to conception, but not during the pregnancy. Chromosomal analysis of the infant revealed trisomy 13 with a D/D translocation. Lysergic acid diethylamide may have damaged maternal germ cells prior to fertilization, inducing chromosomal rearrangement. Fertilization of a gamete with unbalanced chromosome complement may be the direct cause of the chromosomal aberration in the offspring.
Multi-Imaging Assessment of the Congenital Mitral Arcade
Authors: Michael F. Morris, Eric E. Williamson, Yan Topilsky, Raul E. Espinosa, Frank Cetta, Harold M. Burkhart, Maurice Enriquez-Sarano, Rakesh M. Suri, Hector I. Michelena
Journal: Journal of the American College of Cardiology (2011)
Altered Age-Related Blood Pressure Pattern in Type 1 Diabetes
Authors: Mats Rönnback, Johan Fagerudd, Carol Forsblom, Kim Pettersson-Fernholm, Antti Reunanen, Per-Henrik Groop
Journal: Circulation (2004)

Pulse pressure (PP) increases with age as a result of arterial stiffening and is a powerful predictor of cardiovascular disease. Type 1 diabetes is associated with excessive cardiovascular mortality and increased arterial stiffness. We examined whether the age-related blood pressure changes in type 1 diabetic patients differ from those of the nondiabeticWe performed a cross-sectional, case-control study of 2988 consecutively selected diabetic subjects and 5486 randomly selected nondiabetic control subjects. Blood pressure was measured twice by mercury sphygmomanometry on a single occasion. Compared with controls, diabetic subjects had a higher systolic blood pressure in all age groups, whereas diastolic blood pressure was higher in those <40 years but lower in those >45 years of age. Consequently, diabetic subjects had a higher PP and a higher prevalence of isolated systolic hypertension. The early age-related rise in PP was more pronounced in subjects with diabetic nephropathy but was also evident in diabetic subjects with normal albumin excretion rate. In a multiple regression analysis, PP in diabetic patients was associated with age, male sex, duration of diabetes, and albuminuria.A higher systolic pressure and an earlier decrease in diastolic pressure result in a higher and more rapidly increasing PP in type 1 diabetic patients. Our findings indicate accelerated arterial aging, which may contribute to the higher cardiovascular morbidity and mortality in these patients.
IMPACTS OF GENSINI SCORE FOR CORONARY ANGIOGRAPHIC SEVERITY ON OUTCOMES OF OUT-OF-HOSPITAL CARDIAC ARREST DUE TO ACUTE MYOCARDIAL INFARCTION PATIENTS
Authors: Nobuaki Kokubu, Mamoru Hase, Junichi Nishida, Naohiro Funayama, Atsushi Mochizuki, Atsuko Muranaka, Shinya Shimoshige, Satoshi Yuda, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Tetsuji Miura
Journal: Journal of the American College of Cardiology (2011)
LABORATORY OBSERVATIONS ON HYDROPHOBIA IN OHIO.
Authors: A. P. OHLMACHER
Journal: JAMA (1901)

In the past five years several cases of suspected hydrophobia have been brought to my notice from various quarters of the State of Ohio, and I desire to lay before you a condensed account of them. <h3>Case 1.</h3> —This case came to my laboratory at the Medical Department of the University of Wooster, Cleveland (now the Cleveland College of Physicians and Surgeons), in the winter of 1896, Dr. J. F. Hobson, Lakewood, Ohio, submitting it. Two weeks previously a dog, acting suspiciously, had bitten a boy in Lakewood; the dog was killed and buried, and the lad came to Dr. Hobson for treatment of the wound. His parents became anxious and alarmed, and had the dog's carcass exhumed, and it was brought to the laboratory frozen and in good state of preservation. Three rabbits and one dog were inoculated with an emulsion of the suspected animal's medulla, by the subdural
965-52 Relationship Between Heart Chymase and ACE Activity in Dogs with Volume Overload Hypertrophy and Increased Cardiac Angiotensin Peptide Levels
Authors: Eduardo Balcells, Oing C. Meng, Suzanne Oparil, Terry S. Elton, Ingrid Straeter-Knowlan, Sanford P. Bishop, Gerald H. Hankes, Ray S. Dillon, Louis J. Dell'ltalia
Journal: Journal of the American College of Cardiology (1995)
The Pharmacological Basis of Therapeutics
Authors: Norman A. David
Journal: JAMA (1966)

In the long-awaited third edition of this encyclopedic complete text on pharmacology and the rational use of drugs, 42 authors share the herculean task of reviewing the flood of recent literature. Under single or dual authorship they contribute the 76 chapters in the 18 sections. The liberal use of extract (fine) type as a space-saving device allows nearly twice as much material under one cover. Although portions printed in smaller type are of somewhat lesser importance, in most cases it will be necessary and profitable to read these. For example, extract type is used to narrate the historical background and to discuss complex structure-activity relationships, significant laboratory and clinical studies, the types of preparations, dosages and routes of administration, side effects and adverse reactions, and the therapeutic uses.  Each chapter offers a complete and up-to-date review. Usually, enough information is given so that one finds it rarely necessary to refer
Ventricular Function
Authors: ROBERT B. CASE, ERIK BERGLUND, STANLEY J. SARNOFF
Journal: Circulation Research (1954)

Left main coronary artery blood flow, cardiac output and pressures in the pulmonary artery, the aorta and both atria were continuously recorded in the dog. Restriction of left coronary flow increased left atrial pressure substantially, but right atrial pressure only slightly; left ventricular work, cardiac output and arterial pressure fell markedly. During restriction of left coronary flow, the left ventricular function curve (modified Starling curve), which does not normally show a descending limb even at high filling pressures, developed a pronounced descending limb. Unilateral ventricular failure was demonstrated.
Combined Residencies Among Community Hospitals
Authors: Max Michael
Journal: JAMA (1968)

This is a report of a decade of experience I have had with attempts at coordination of educational programs in a group of community hospitals. It has been imperative to maintain a state of flexibility since the approach has been one of studied trial and error. There have been some significant results. Jacksonville (Fla) Hospitals Educational Program (JHEP) was founded in 1958. The charge in its charter is to "coordinate the training of interns and residents among several member hospitals." The real reason behind the founding of this nonprofit consortium of hospitals is rather difficult to ascertain. I suppose, basically, like most maneuvers, it was aimed at providing a more attractive lure for that most precious commodity, the intern and resident. In this, as in all such efforts, if the attraction of interns and residents remains the sole purpose, then failure will be the result. If on the other hand,
Lentivirally Transduced Recipient-derived Dendritic Cells Serve to Ex Vivo Expand Functional FcRγ-sufficient Double-negative Regulatory T Cells
Authors: Christopher W Thomson, Miriam E Mossoba, Christopher Siatskas, Wenhao Chen, April Sung, Jeffrey A Medin, Li Zhang
Journal: Molecular Therapy (2007)

αβTCR+CD4-CD8- double-negative (DN) T regulatory (Treg) cells have recently been shown to suppress antigen-specific immune responses mediated by CD8+ and CD4+ T cells in mice and humans. In this study, we developed a system to expand DN Treg cells for transplantation therapy that exclusively uses recipient-derived immune cells and confers a high degree of safety as the protocol does not involve the direct injection of lentiviral vectors. Recipient-derived dendritic cells (DCs) were transduced with lentiviral vectors that express major histocompatibility complex class I Ld antigen (LV-Ld), which is expressed by the donor graft but is allogeneic to the graft recipient. LV-Ld-transduced mature DCs (mDCs) were able to expand effectively both FcRγ-/- and FcRγ+/+ DN T cells. After expansion with LV-Ld-transduced mDCs, only the FcRγ+/+ DN Treg cells maintained their ability to suppress CD8+ T cells in vitro. In addition, adoptive transfer of the FcRγ+/+ex vivo expanded DN Treg cells significantly prolonged the survival of Ld+ skin grafts. This study is the first description of successful ex vivo expansion of antigen-specific DN Treg cells using genetically modified syngeneic DCs for adoptive immunotherapy and demonstrates that although FcRγ-/- DN T cells can be expanded, they do not gain regulatory ability.
Assessing the New Medicare Prescription Drug Law
Authors: Robert B. Doherty
Journal: Annals of Internal Medicine (2004)

The Medicare Modernization Act (MMA) is the product of a political compromise to attract moderate Republicans and enough Democrats without losing Republican conservatives. The compromise offered more private health plans to beneficiaries while maintaining and improving traditional Medicare's benefits. This compromise did not settle the debate over the legislation, which is a major issue in the 2004 elections. Voters poorly understand the law because of its complexity. In this paper, I explain how the policy decisions made by the U.S. Congress have contributed to the law's complexity and controversy. I examine the new private health plan options that will be offered to beneficiaries, improvements made to traditional Medicare, and the impact of introducing income-based determinations into Medicare. I also discuss the impact of the drug benefit on beneficiaries in different income and assets categories and Congress's decision to prohibit the federal government from directly negotiating prices with drug manufacturers. I conclude by assessing the major claims made by critics and proponents. Both might be more circumspect in their assessments of the law's impact, since it is impossible to predict how a law of such complexity, with so many human variables, will work out in the end. The MMA is a worthwhile but imperfect effort to extend drug coverage to seniors who are most in need. It deserves neither condemnation nor indiscriminate praise but instead a commitment to help it succeed.
THE ORIGIN OF THE LEPRA CELL
Authors: Jean Oliver
Journal: The Journal of Experimental Medicine (1926)

1. By means of the method of vital staining it is found that the lepra cell in rat leprosy is derived from the histiocyte. 2. From the similarity in morphology and function of the lepra cells in this condition and those of human leprosy, it seems likely that derivation of the cells in the two conditions is similar.
Endoscopic submucosal dissection for early gastric cancer performed by supervised residents: assessment of feasibility and learning curve
Authors: Shunsuke Yamamoto, N. Uedo, R. Ishihara, N. Kajimoto, H. Ogiyama, Y. Fukushima, Sachiko Yamamoto, Y. Takeuchi, K. Higashino, H. Iishi, M. Tatsuta
Journal: Endoscopy (2009)

See also: Commentaire de travail de Shunsuke Yamamoto et al., pp. 923Endoscopy 2009; 41(11): 1008-1008DOI: 10.1055/s-0032-1306751
Persistence of Neointimal Growth 12 Months After Intervention and Occurrence of Delayed Restenosis in Patients With Left Main Coronary Artery Disease Treated With Drug-Eluting Stents
Authors: Marco Valgimigli, Patrizia Malagutti, Carlos A.G. van Mieghem, Sophia Vaina, Jurgen M. Ligthart, George Sianos, Patrick W. Serruys
Journal: Journal of the American College of Cardiology (2006)
Gastroduodenal Candidiasis Occurring without Underlying Diseases (Primary Gastroduodenal Candidiasis): Report on two Cases
Authors: G. Minoli, V. Terruzzi, A. Rossini
Journal: Endoscopy (1979)

Two cases of primary and isolated gastroduodenal candidiasis are described. The diagnosis of the mycotic infection was based on the discovery of hyphae in the biopsy obtained through the gastroscope (Olympus GIF-K). Clinical, endoscopic and histologic appearances are discussed.
Neuropsychiatric Features of Medical Disorders
Authors: Peter Reich
Journal: JAMA (1982)

Familiarity with the psychiatric manifestations of common medical disorders can improve the clinical skills of psychiatrists and internists, yet the material presented in this tightly organized book is largely neglected in standard medical and psychiatric texts. When the mind is seen as a sensitive barometer of both physical and emotional health, the artificial dichotomy between mind and body melts away. The authors of this book are trained in medicine and psychiatry, and their presentation reflects their knowledge of both fields. The book begins with discussion of anxiety, depression, fatigue, and hallucinations as examples of nonspecific psychological symptoms that can be associated with numerous physical disorders. After describing the pathophysiology of these symptoms, the book follows the format of a traditional textbook of medicine, with separate sections on disorders of the various systems of the body. Each section includes an orientation to the pathophysiology of major disorders, followed by the psychiatric
Case definition is too loose
Authors: E. J Wilson, J. Williams, B. McCarron
Journal: BMJ (2009)

RGS7, RGS11, and their binding partner Gβ5 are localized to the dendritic tips of retinal ON bipolar cells (ON-BPC), where mGluR6 responds to glutamate released from photoreceptor terminals by activation of the RGS7/RGS11 substrate, Gαo. To determine their functions in retinal signaling, we investigated cell-specific expression patterns of RGS7 and RGS11 by immunostaining, and measured light responses by electroretinography in mice with targeted disruptions of the genes encoding them. RGS7 staining is present in dendritic tips of all rod ON-BPC, but missing in those for subsets of cone ON-BPC, whereas the converse was true for RGS11 staining. Genetic disruption of either RGS7 or RGS11 produced delays in the ON-BPC-derived electroretinogram b-wave, but no changes in the photoreceptor-derived a-wave. Homozygous RGS7 mutant mice had delays in rod-driven b-waves, whereas RGS11 mutant mice had delays in rod-driven, and especially in cone-driven b-waves. The b-wave delays were further enhanced in mice homozygous for both RGS7 and RGS11 gene disruptions. Thus, RGS7 and RGS11 act in parallel to regulate the kinetics of ON bipolar cell responses, with differential impacts on the rod and cone pathways.
197 LIVER TRANSPLANTATION FOR CHOLANGIOCARCINOMA – SELECTION IS ESSENTIAL FOR ACCEPTABLE RESULTS
Authors: S. Friman, A. Foss, H. Isoniemi, M. Olausson, K. Hockerstedt, S. Yamamoto, T.H. Karlsen, L. Backman, B.G. Ericzon
Journal: Journal of Hepatology (2008)