Pre-existing Conditions, Placebo Reactions, and "Side Effects"
Authors: D. M. GREEN
Journal: Annals of Internal Medicine (1964)

Article1 February 1964Pre-existing Conditions, Placebo Reactions, and "Side Effects"D. M. GREEN, M.D., F.A.C.P.D. M. GREEN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-255 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of these studies was to explore the possible relationship between pretreatment conditions and placebo reactions and the subsequent appearance of symptoms that could be regarded as drug side effects.Since side effects tend to be the exception rather than the rule, the evidence for their existence is often circumstantial. As a consequence, symptoms or signs of the disease being treated, or of some unrelated condition or unfavorable reactions to the act of administering a medication, could represent sources of potential confusion.That adverse effects may follow the giving of a presumed medication has been well-established through placebo studies...References1. BEECHER HK: The powerful placebo. JAMA 159: 1602, 1955. CrossrefMedlineGoogle Scholar2. COWANDIEHLBAKER DWHSAB: Vitamins for the prevention of colds. JAMA 120: 1268, 1942. CrossrefGoogle Scholar3. CYTRYNGILBERTEISENBERG LAL: The effectiveness of tranquilizing drugs plus supportive psychotherapy in treating behavior disorders in children: A double-blind study of eighty outpatients. Amer. J. Orthopsychiat. 30: 113, 1960. CrossrefGoogle Scholar4. DIEHL HS: Medicinal treatment of the common cold. JAMA 101: 2042, 1933. CrossrefGoogle Scholar5. DIEHLBAKERCOWAN HSABDW: Cold vaccines, a further evaluation. JAMA 115: 593, 1940. CrossrefGoogle Scholar6. 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Author, Article, and Disclosure InformationAffiliations: St. Louis, MissouriFrom Grove Laboratories, Division of Bristol-Myers Company, St. Louis, Missouri.The studies upon which this report is based were supported by grants from Grove Laboratories, Division of Bristol-Myers Company, St. Louis, Missouri.Requests for reprints should be addressed to D. M. Green, M.D., Vice President, Research and Development, Grove Laboratories, 8877 Ladue Road, St. Louis 24, Missouri. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Dark Side of Body SensationsEffect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal SymptomsSomatosensory amplification – An old construct from a new perspectiveAttribution-Based Nocebo Effects. 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Clinical Factors Influencing SusceptibilityJAY W. SMITH, M.D., LARRY G. SEIDL, M.D., LEIGHTON E. CLUFF, M.D., F.A.C.P. 1 February 1964Volume 60, Issue 2_Part_1Page: 255-265KeywordsAdverse reactionsRisk managementSigns and symptoms Issue Published: 1 February 1964 PDF downloadLoading ...