Immunosuppressive Drugs and Acute Leukemia
Authors: CHARLES D. COBAU
Journal: Annals of Internal Medicine (1973)

Letters1 July 1973Immunosuppressive Drugs and Acute LeukemiaCHARLES D. COBAU, M.D., F.A.C.P., ROBERT P. SHEON, M.D., F.A.C.P., ALLAN B. KIRSNER, M.D.CHARLES D. COBAU, M.D., F.A.C.P.Search for more papers by this author, ROBERT P. SHEON, M.D., F.A.C.P.Search for more papers by this author, ALLAN B. KIRSNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-1-131_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The introduction of cytotoxic drugs in the treatment of connective tissue disease has raised concern about the induction of hematologic and other malignancy in these patients (1). We report on a patient with rheumatoid arthritis and rheumatoid vasculitis who was treated with several cytotoxic drugs over a 5-year period and who subsequently developed acute granulocytic leukemia. For the last year of his life he was treated with azathioprine and prednisone, a combination of drugs previously implicated in the induction of neoplasia in renal allograft recipients (2).A 67-year-old man developed rheumatoid arthritis in 1960 and rheumatoid vasculitis...References1. LIPSMEYER E: Development of malignant cerebral lymphoma in a patient with systemic lupus erythematosus treated with immunosuppression. Arthritis Rheum 15:183-186, 1972 CrossrefMedlineGoogle Scholar2. WALKERGILLCORSON DTJ: Leiomyosarcoma in a renal allograft recipient treated with immunosuppressive drugs. JAMA 219:1593-1597, 1972 MedlineGoogle Scholar3. AKSOYDINCOLERDEM MKS: Acute leukemia due to chronic exposure to benzene. Am J Med 52:160-166, 1972 CrossrefMedlineGoogle Scholar4. NILSENMISSALCONDEMI LMJ: Appearance of Hodgkin's disease in a patient with systemic lupus erythematosus. Cancer 20:1930-1933, 1967 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHARLES D. COBAU, M.D., F.A.C.P.; ROBERT P. SHEON, M.D., F.A.C.P.; ALLAN B. KIRSNER, M.D.Affiliations: Department of Internal Medicine Medical College of Ohio at Toledo Division of Rheumatology Toledo Clinic Foundation Toledo, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAzathioprine: Association with Therapy-related Myelodysplastic Syndrome and Acute Myeloid LeukemiaCASE REPORTAssociation of non-Hodgkin's lymphoma with rheumatoid arthritisRheumatologic Manifestations of CancerAcute Granulocytic Leukemia Following Systemic Lupus ErythematosusMyelodysplasia in Cadaver Renal Allografts: A Report of Four CasesIncidence of neoplasms in patients with rheumatoid arthritis exposed to different treatment regimensPharmaco-epidemiology—Drugs, arthritis, and neoplasms: industry contribution to the dataSerial incidence of bone marrow GM-CFC prior to the development of acute non-lymphoblastic leukaemia in a child treated for non-Hodgkin's lymphomaTherapy-related leukemia associated with myelofibrosis. 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