tbuckley/cabot-search huggingface dataset:
THE LIFE-SPAN AND RECIRCULATION OF MARROW-DERIVED SMALL LYMPHOCYTES FROM THE RAT THORACIC DUCT
Authors: Jonathan C. Howard
Journal: The Journal of Experimental Medicine (1972)

These experiments describe the preparation of pure marrow-derived lymphocyte suspensions from the thoracic duct of thymectomized, irradiated rats reconstituted with bone marrow cells. The majority of marrow-derived cells were small lymphocytes morphologically indistinguishable from small lymphocytes in thoracic duct lymph of normal donors. Marrow-derived small lymphocytes (B lymphocytes) were a predominantly long-lived population; the frequency of short-lived B lymphocytes in the thoracic duct was not significantly higher than the frequency of short-lived small lymphocytes in normal lymph. B lymphocytes transferred to normal recipients recirculated from blood to lymph. The first appearance of intravenously injected B lymphocytes in the thoracic duct was delayed relative to lymphocytes from normal donors and there was no clear cut modal recirculation time. Nevertheless their recirculation over a 48 hr period after transfusion was of the same order of magnitude as that of lymphocytes from normal donors.
Russia's youth faces worst crisis of homelessness and substance misuse since second world war
Authors: Andrew Osborn
Journal: BMJ (2005)

Russia's youth is caught up in one of the worst health crises in the country's history, with unprecedented numbers of children and teenagers turning to cigarettes, alcohol, and drugs, Russia's interior minister has warned. Rashid Nurgaliyev blamed the situation on the virtual collapse of the Russian health service in 1991, when the Soviet Union fell, and on the economic misery and moral crisis that has affected the country ever since.

He said that four million Russian teenagers were drug users (of a total of 144 million) and that one million …
A sound approach to the study of culture
Authors: L. G. Barrett-Lennard, V. B. Deecke, H. Yurk, J. K. B. Ford
Journal: Behavioral and Brain Sciences (2001)

Rendell and Whitehead's thorough review dispels notions that culture is an exclusive faculty of humans and higher primates. We applaud the authors, but differ with them regarding the evolution of cetacean culture, which we argue resulted from the availability of abundant but spatially and temporally patchy prey such as schooling fish. We propose two examples of gene-culture coevolution: (1) acoustic abilities and acoustic traditions, and (2) transmission of environmental information and longevity.
Blockade of TNF-α Decreases Both Inflammation and Efficacy of Intrapulmonary Ad.IFNβ Immunotherapy in an Orthotopic Model of Bronchogenic Lung Cancer
Authors: Michael J. Wilderman, Samuel Kim, Collin T. Gillespie, Jing Sun, Veena Kapoor, Anil Vachani, Daniel H. Sterman, Larry R. Kaiser, Steven M. Albelda
Journal: Molecular Therapy (2006)

Adenoviral immuno-gene therapy using interferon-beta has been effective in an orthotopic model of lung cancer. However, pulmonary inflammation induced by adenoviral (Ad) vectors will almost certainly limit the maximally tolerated dose. On the other hand, the strong innate immune response generated by the vector may be helpful in initiating the adaptive immune response required for efficacy. The goals of this study were to develop an effective approach to inhibit Ad.IFNbeta-mediated acute pulmonary inflammation and to determine whether this reduction of Ad-mediated inflammation decreased the therapeutic efficacy of Ad.IFNbeta in a mouse model of bronchioloalveolar cancer. Our data show that anti-TNF-alpha antibodies can blunt the innate pulmonary immune response induced by Ad vectors, even in sensitized animals. However, this effect also inhibited the ability of the animal to generate anti-tumor immune responses and reduced survival in an orthotopic lung cancer model responsive to Ad.IFNbeta treatment. Interestingly, in a flank model of tumor using a cell line derived from the lung tumor, TNF-alpha blockade did not inhibit efficacy. These data suggest that the innate immune response to adenovirus in the lung may be important in immuno-gene therapy of lung cancer. Therapeutic application of anti-inflammatory therapy in immuno-gene therapy strategies should thus be undertaken with caution.
Right Bundle-Branch Block Associated with Left Superior or Inferior Intraventricular Block
Authors: PATRICK J. SCANLON, RAY PRYOR, S. GILBERT BLOUNT
Journal: Circulation (1970)

In an 11-year period 209 cases of partial bilateral bundle-branch block were seen. These included patients with right bundle-branch block and either left superior or left inferior intraventricular block. The majority of patients had evidence of coronary artery disease or hypertension, though a significant number had no clinical evidence of heart disease. The majority of patients had follow-up ECG tracings, with an average follow-up for the whole group of about 2 years. The incidence of complete heart block was 14.4% (30 of 209). Complete heart block developed more than 10 years after the discovery of bilateral bundle-branch block in several patients. It is anticipated that with more complete and longer follow-up the incidence of complete heart block will be even higher.
Effects of sodium valproate with special reference to weight
Authors: J Egger, E M Brett
Journal: BMJ (1981)

Aquagenic pruritus SIR,-As the investigators who originally coined the terms aquagenic urticaria and aquagenic pruritus,' 2 which were so roundly criticised by the classicists in your issues of 25 July (p 310) and 15 August (p 493), we feel urged to reply.Words are created to transmit new ideas.As such, they arise to serve the reader, not the guardians of linguistic purity.Let the classi- cists consider the poor reader who views a "hydrogenic" disease as one producing hydrogen, and a "hydrogenous" disease as one beyond his comprehension.We rest our case for "aquagenic" on the principle that clarity is a greater virtue than purity.
Medical training in developing countries
Authors: B Senewiratne
Journal: BMJ (1976)

43of cigarette'-and have also shown that smoking behaviour is influenced by per- sonalitv characteristics.'Alterations in smok- ing behaviour involve changes both in puff- ing rate and in depth of inhalation, each of which may modify the amount of nicotine, tar, and carbon monoxide absorbed.The present subjects decreased their puffing rate as pregnancy progressed but presumably in- haled more deeply, with the result that they managed to obtain the same amount of nicotine but apparentlv less carbon monoxide.The cause of these changes is not clear, but the findings illustrate the dangers of extrapolation of data obtained during struc- tured smoking regimens to real-life situations.
Nonsteroidal Anti-inflammatory Drugs and Acute Cortical Necrosis
Authors: PAUL D. SCHNEIDER
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 August 1986Nonsteroidal Anti-inflammatory Drugs and Acute Cortical NecrosisPAUL D. SCHNEIDER, M.D.PAUL D. SCHNEIDER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-2-303_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Nonsteroidal anti-inflammatory drugs are associated with various nephrologic syndromes, most of which are self-limiting when therapy with the drug is stopped (1). Chronic renal failure with interstitial fibrosis or papillary necrosis has been reported previously (2). The two cases reported here indicate that acute cortical necrosis with irreversible renal failure may also be related to nonsteroidal anti-inflammatory drugs.Patient 1: A 73-year-old woman became acutely ill with abdominal pain and nausea, without vomiting, diarrhea, fever, or symptomatic hypotension. She complained of decreased urine volume within 6 hours of the onset of her illness. She was hospitalized 12...References1. CLIVE D and STOFF J. Renal syndromes associated with nonsteroidal anti-inflammatory drugs. N Engl J Med. 1984;310:563-72. CrossrefMedlineGoogle Scholar2. ADAMS D, MICHAEL J, BACON P, HOWIE A, MCCONKEY B, and ADU D. Non-steroidal anti-inflammatory drugs and renal failure. Lancet. 1986;1:57-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL D. SCHNEIDER, M.D.Affiliations: Internal Medicine Associates Inc. P.S.; Tacoma, WA 98405 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNaproxen induced acute interstitial nephritis with renal cortical necrosisIbuprofenToxic NephropathyVascular causes of renal failureAcute Renal Cortical Necrosis—A Study of 113 PatientsNonsteroidal Anti-inflammatory Drugs and the Risk for Chronic Renal DiseaseDale P. Sandler, PhD, F. Rebecca Burr, MS, Clarice R. Weinberg, PhDDrugs and the KidneySouthwestern Internal Medicine Conference: Analgesic NephropathyAnti-inflammatory analgesics and drugs used in rheumatoid arthritis and gout 1 August 1986Volume 105, Issue 2 Page: 303-304 Keywords Drug therapy Drugs Fevers Fibrosis Hypotension Nausea Necrosis Renal failure Urine Vomiting ePublished: 1 December 2008 Issue Published: 1 August 1986 PDF downloadLoading ...
[241] PREDICTIVE FACTORS OF SPONTANEOUS BACTERIAL PERITONITIS IN CIRRHOTIC PATIENT S. RESULTS OF A PROSPECTIVE MULTICENTER STUDY
Authors: J.B. Nousbaum, J.F. Cadranel, C. Bessaguet, P. Nahon, E. Nguyen-Khac, R. Moreau, T. Thevenot, C. Silvain, C. Bureau, O. Nouel, C. Pilette, T. Paupard, A. Pauwels, T. Sapey, I.D. Grange, A. Tran, C. Club
Journal: Journal of Hepatology (2007)
Balancing Access and Innovation
Authors: Rahul Rajkumar, Aaron S. Kesselheim
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of A.C.T.H. on Hunner's Ulcer of the Urinary Bladder
Authors: J. Burke, H. K. Vernon
Journal: BMJ (1952)

et al. (1950) found significant but subclinical prolongatiop of the prothrombin time in cases without toxic symptoms.The present case showed abnormal liver-function tests but no jaundice or bile in the urine.All five cases in which hepatic disorders have been recorded (Cuthbert, 1950; Livingstone and Street, 1950; Scott and McCann, 1950; Hurrell, 1950) have also had evidence of allergy-eosinophilia, urticaria, or positive skin reaction.No jaundice is reported when normal doses are given following desensitization.It would appear that the jaundice is probably due to a toxic hepatitis of allergic origin.The occurrence of.simultaneous sensitization to strepto- mycin and P.A.S. may be purely coincidental.In view of the fact that many workers have successfully continued strep- tomycin therapy in spite of P.A.S. reactions, this would appear to be so.The present case illustrates the confusion that can arise when using both drugs, and the similarity of the drug rashes and fever found.The temperature does not necessarily drop immediately after the cessation of the drug in P.A.S. sensitization, but it is clearly as well to stop both drugs at the onset of pyrexia and rashes.
Sticker Shock Sharpens Focus on Biologics
Authors: C. McNeil
Journal: JNCI Journal of the National Cancer Institute (2007)

Never mind their novel targets and mechanisms. It’s the cost of new biologic agents that’s creating a buzz these days. At thousands of dollars a month, which can mean many tens of thousands for some regimens, sticker shock has generated recent, prominent articles in both the national and trade press. At the same time, debate is intensifying over what such costs mean for society and what — if anything — should be done about them. Drug companies, private insurers, and government are all talking about — and often beginn ing to do something about — costs. Each is ap proaching the is sue from its own perspective. On one level, the argument is about macroeconomics. Neal Meropol, M.D. , of Fox Chase Cancer Center in Philadelphia, pointed out that cancer drugs account for 40% of all Medicare drug expenditures. That makes them a major contributor to the country’s high health care costs, now about 17% of our gross domestic product (GDP) and growing. That percentage is much higher than in other developed countries with higher life expectancies, he said at a forum on cancer care costs at the American Association of Cancer Research annual meeting. High health costs have also been blamed
Efficacy of Varenicline for Smoking Cessation
Authors: Alain Dervaux, Mostafa Kanit, Xavier Laqueille
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement
Authors: Jesse A Green, Kazuhiro Suzuki, Bryan Cho, L David Willison, Daniel Palmer, Christopher D C Allen, Timothy H Schmidt, Ying Xu, Richard L Proia, Shaun R Coughlin, Jason G Cyster
Journal: Nature Immunology (2011)
Selective Functional Exhaustion of Hematopoietic Progenitor Cells in the Bone Marrow of Patients With Postinfarction Heart Failure
Authors: Christine K. Kissel, Ralf Lehmann, Birgit Assmus, Alexandra Aicher, Jörg Honold, Ulrich Fischer-Rasokat, Christopher Heeschen, Ioakim Spyridopoulos, Stefanie Dimmeler, Andreas M. Zeiher
Journal: Journal of the American College of Cardiology (2007)
Oral Contraceptives as Ovarian Cancer Prevention: In the News
Authors: K. Crane
Journal: JNCI Journal of the National Cancer Institute (2011)

This article focuses on ovarian cancer and the role that oral contraceptives play in the prevention of the disease. It discusses how oral contraceptives are gaining official recognition in their prevention efforts and describes how the protective benefit may work. It also touches on the FDA approval of Phase I and II trials of an ovarian cancer vaccine for established ovarian cancers.
Simon John Boniface
Authors: John Hodges
Journal: BMJ (2004)

Consultant neurophysiologist Addenbrooke's Hospital, Cambridge (b 1959; q University College London 1983; MA, MD, FRCP), died from nocturnal seizure on 27 November 2003.​2003.




Figure 1




Simon had an enduring passion for clinical neuroscience and for a wide range of outside interests, including the music of Elvis Costello. After training in neurology and ophthalmology he settled on a career in neurophysiology. He undertook an MD on transcranial magnetic stimulation while working as a Medical Research Council training fellow at the Radcliffe Infirmary in Oxford. In 1995 he was appointed to the first full time consultant position in neurophysiology at Addenbrooke's Hospital. He co-edited a book, Plasticity in the Human Nervous System. Separated from his wife, Maria, he remained close to his three children. He was fortunate to have found a new soulmate, Sara.
Heroin Maintenance for Heroin Addicts: Issues and Evidence
Authors: Lorrin M. Koran
Journal: New England Journal of Medicine (1973)

Abstract American society is again debating whether to allow maintenance doses of heroin in the treatment of heroin addicts. Carefully designed clinical research on the safety and efficacy of heroin maintenance should be undertaken, particularly with addicts not helped by current treatments. Such research would determine whether heroin maintenance is part of the treatment of choice for some addicts and would add to the present quite limited understanding of addiction. Medically administered heroin seems unlikely to cause addicts serious physiologic or mental harm. Moreover, British experience with heroin maintenance suggests that it is not incompatible with psychologic and social rehabilitation. Reducing the crime rate, however, should not be a heroin-maintenance program's major goal, since most urban crime appears unrelated to addiction. Congress has begun to consider legislation to outlaw heroin-maintenance treatment. Informed medical opinion should be contributed to these deliberations.
Case Mix and Resource Utilization by Uninsured Hospital Patients in the Boston Metropolitan Area
Authors: Joel Weissman
Journal: JAMA (1989)

Rising competitive pressures may place uninsured patients at risk for receiving fewer services than insured patients with similar medical conditions. To examine this possibility we studied the case mix, length of stay, and number of procedures for 65,032 patients listed as self-pay or free care, Blue Cross, or Medicaid at 52 hospitals in the Boston, Mass, area during 1983. We found that the overall case mix severity index (based on expected length of stay per diagnosis related group) for uninsured patients was 30% higher in public hospitals and 8% higher in major teaching hospitals compared with other institutions. Across all hospitals, the severity index of uninsured patients was similar to that of insured patients. However, after adjusting for diagnosis related group case mix, uninsured patients had, on average, 7% shorter stays (5.36 vs 5.79 days) and underwent 7% fewer procedures (1.16 vs 1.25) than Blue Cross patients, the differences varying with hospital type. Uninsured patients also had shorter stays on average than Medicaid patients (5.36 vs 5.87 days), but they underwent a similar number of procedures. These results suggest that patients who lack insurance may receive unequal treatment even after being hospitalized.The hospital care received by uninsured patients in the Boston, Mass., metropolitan area during 1983 was compared with that of patients insured by Blue Cross or Medicaid. Even after controlling for diagnosis related group case mix, uninsured patients were found to have had an average of 7% shorter stays and undergone 7% fewer procedures than Blue Cross patients. Uninsured patients also had shorter stays on average than Medicaid patients though, except in public hospitals, they underwent a similar number of procedures. These data suggest that patients who lack insurance may receive unequal treatment in hospitals.
Experience with gemtuzumab ozogamycin (“mylotarg”) and all-trans retinoic acid in untreated acute promyelocytic leukemia
Authors: Elihu H. Estey, Francis J. Giles, Miloslav Beran, Susan O'Brien, Sherry A. Pierce, Stefan H. Faderl, Jorge E. Cortes, Hagop M. Kantarjian
Journal: Blood (2002)
Modification of regional function of ischaemic myocardium by the alteration of arterial pressure in dogs
Authors: S. SASAYAMA, G. OSAKADA, M. TAKAHASHI, T. SHIMADA, C. KAWAI
Journal: Cardiovascular Research (1980)

The effects of alterations of arterial pressure by nitroprusside and methoxamine on regional myocardial function were studied during total coronary occlusion and during partial coronary constriction in open chest dogs. Animals were instrumented with a left ventricular micromanometer, an electromagnetic flow probe around the left circumflex coronary artery, and three pairs of ultrasonic crystals in a control, marginally ischaemic, and ischaemic segments. In nine dogs, when the coronary artery was totally occluded by a hydraulic cuff placed distal to the flow probe, the end-diastolic length of all three segments was increased, and shortening was rapidly replaced by systolic expansion in the ischaemic segment. Active shortening decreased by 68% in the marginal segment, while it increased by 21% in the control segment. With nitroprusside infusion, peak systolic pressure was reduced from 15.2 to 11.3 kPa and hypokinesis of the marginal segment was improved to 45% of control value with a concomitant decrease in end-diastolic length by 5%. With methoxamine, left ventricular systolic pressure was elevated to 18.5 kPa, and marginal segment shortening further deteriorated to 19% of control with chamber enlargement. In 6 dogs, coronary flow was limited by a screw-driven metal clamp. When mean coronary flow was reduced by 50% of control value, stable hypokinesis was produced in the ischaemic segment. Nitroprusside infusion induced the same haemodynamic changes, however, shortening of the ischaemic segment deteriorated further and a passive bulge appeared. Methoxamine improved the percentage shortening from 1.2 to 6.4%. Thus, interventions with an agent which changes afterload in left ventricular ejection have multiple and complex effects on the contractile function of the ischaemic myocardium and, depending on the magnitude of coronary blood flow reduction, a potentially beneficial drug can be determined to an ischaemic myocardium.