Biochemical Studies in Thalassemia
Authors: Ananda S. Prasad, M. Diwany, Mamdouh Gabr, Harold H. Sandstead, Newal Mokhtar, Anisa El Hefny
Journal: Annals of Internal Medicine (1965)

Article1 January 1965Biochemical Studies in ThalassemiaANANDA S. PRASAD, M.B., B.S., PH.D., M. DIWANY, M.D., M.R.C.P., MAMDOUH GABR, M.D., HAROLD H. SANDSTEAD, M.D., NEWAL MOKHTAR, M.B., B.S., ANISA EL HEFNY, M.B., B.S.ANANDA S. PRASAD, M.B., B.S., PH.D.Search for more papers by this author, M. DIWANY, M.D., M.R.C.P.Search for more papers by this author, MAMDOUH GABR, M.D.Search for more papers by this author, HAROLD H. SANDSTEAD, M.D.Search for more papers by this author, NEWAL MOKHTAR, M.B., B.S.Search for more papers by this author, ANISA EL HEFNY, M.B., B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-1-87 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the description of a syndrome comprised of erythroblastosis, splenomegaly, and anemia with a familial and racial incidence by Cooley and Lee (1) in 1925, many cases from various parts of the world have been reported (2-4). From Egypt, Diwany (5) first reported two cases in 1944, and since then others have been described (6-9). These reports have documented the presence of this disease in Egypt, but do not provide detailed biochemical and hematological data on the cases.Abnormal iron metabolism in Cooley's anemia (thalassemia) has been established (10-12), and the presence of high serum levels of copper has been...References1. COOLEYLEE TBP: Series of cases of splenomegaly in children with anemia and peculiar bone changes. Trans. Amer. Pediat. Soc. 37: 29, 1925. Google Scholar2. CHERNOFF AI: The distribution of the thalassemia gene: a historical review. Blood 14: 899, 1959. CrossrefMedlineGoogle Scholar3. WENTMACIVER LNJE: Thalassemia in the West Indies. Blood 17: 166, 1961. CrossrefMedlineGoogle Scholar4. WINTROBE MM: Clinical Hematology, 5th ed., Lea & Febiger, Philadelphia, 1961, p. 700. Google Scholar5. DIWANY M: Erythroblastic anemia with bone changes in Egyptian children: possible Cooley's type. Arch. Dis. Child. 19: 163, 1944. CrossrefMedlineGoogle Scholar6. 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R., the Division of Nutrition, Departments of Medicine and Biochemistry, Vanderbilt University, Nashville, Tenn., and the Pediatric Department, Faculty of Medicine, Munira Children's Hospital, Cairo University, Cairo, Egypt, U.A.R.This study was supported by research contract Nonr 2149 from the Navy Department, Office of Naval Research to Vanderbilt University, Nashville, Tenn., and by an agreement with the National Institutes of Health under Public Law 480.This paper was presented at the Tenth Congress of the International Society of Hematology in Stockholm, Sweden, September 2, 1964.Requests for reprints should be addressed to Ananda S. Prasad, M.D., Wayne State University School of Medicine, Department of Medicine, 1400 Chrsyler Expressway, Detroit 7, Mich. 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