tbuckley/cabot-search huggingface dataset:
Allergy to Flowers
Authors: Robert B. Beede
Journal: JAMA (1962)

ABSTRACT To the Editor:— In addition to the facts mentioned by Dr. Samuel M. Feinberg in his answer to the question of how cut flowers cause allergic reactions (JAMA177:822 [Sept. 16] 1961), I would suggest 2 additional sources of trouble from flowers.The first is from insecticide with which these flowers are frequently sprayed by the florist and to which people are frequently sensitive. In addition, any vegetative material forms an excellent medium on which molds may grow. This may cause trouble for the mold-sensitive individual.
Decision-Making Studies in Patient Management
Authors: Lee B. Lusted
Journal: New England Journal of Medicine (1971)

Abstract Decision analysis provides a method to help the physician choose a course of action consistent with his personal judgments, to relate his preferences to costs, and to act more systematically. Decision analysis uses personal probabilities and deals with the relation of values and costs of patient management procedures. The physician is able to introduce intuitive judgments directly into the decision problem by using a numerical scale to express his uncertainty about a symptom or a diagnosis. His preference for consequences of diagnoses and treatments can be numerically scaled as utility values. Signal-detection theory has been used to develop performance criteria for radiologists' assistants and radiologic systems. The essential feature of the analysis, an operating characteristic curve, is a means for separating the detectability of a signal, a sensory process, from all other factors involved in the decision process.
45 RAPID AND EFFICIENT ANTIGEN PROCESSING AND PRESENTATION OF A PROTECTIVE AND IMMUNODOMINANT HLA-B*27-RESTRICTED HEPATITIS C VIRUS-SPECIFIC CD8+ T CELL EPITOPE
Authors: J. Schmidt, A.K.N. Iversen, S. Tenzer, E. Gostick, D.A. Price, V. Lohmann, P. Bowness, H. Schild, H.E. Blum, P. Klenerman, C. Neumann-Haefelin, R. Thimme
Journal: Journal of Hepatology (2012)
Insights into Leukemogenesis from Therapy-Related Leukemia
Authors: Jens Pedersen-Bjergaard
Journal: New England Journal of Medicine (2005)

Therapy-related acute myeloid leukemia (AML), often presenting as therapy-related myelodysplasia, is the most serious long-term complication of cancer chemotherapy. This disease offers a unique opportunity to study leukemogenesis by relating specific cytogenetic and genetic abnormalities to the biologic effects of cytostatic agents. Two types of drugs, alkylating agents and topoisomerase II inhibitors, have been shown to induce therapy-related leukemia.High risks of therapy-related myelodysplasia and AML were first reported in patients with multiple myeloma who had been treated with melphalan.1 Subsequently, almost all other alkylating agents in clinical use have been shown to be leukemogenic in patients treated for a . . .
Health checks on patients 75 years and over in Nottinghamshire after the new GP contract.
Authors: K. Brown, E. I. Williams, L. Groom
Journal: BMJ (1992)

OBJECTIVE--To investigate annual health checks for patients of 75 years and over required by the 1990 contract for general practitioners. DESIGN--Visits to practices to collect information on how assessments were organised and carried out; completion of questionnaires for every patient who had been assessed in a sample month, using information provided by the practice records. SETTING--20 general practices in one family health services authority. SUBJECTS--Patients of 75 years and over in 20 general practices. RESULTS--Three practices (15%) had not performed checks. Thirteen practices sent a letter to invite patients to undergo a check. Of these practices, seven followed up non-responders. Two practices visited patients9 homes unannounced, and two did checks on an opportunistic basis only. Sixteen practices used a checklist. Sixteen practices involved their practice nurses; at eight of these, doctors also performed checks; in six practices the nurses undertaking the checks had no training in assessing old people. Ten practices assessed more than 75% of their old people in the first year of the new contract. Practices that did not follow up patients who had not responded to the invitation for assessment completed significantly fewer checks. During the sample month, 331 patients were assessed in the 17 practices. 204 new problems were discovered in 143 patients. Significantly more problems per patient were found in inner city areas. CONCLUSIONS--The way health checks were performed varied greatly, both in their organisation and the practices9 attitudes. Many old people did not respond to letters asking if they wanted an assessment but very few refused one if followed up. Forty three per cent of those assessed had some unmet need. The number of new problems found per patient may reduce over the next few years if the assessments are successful. The need for annual assessment should be kept under review and adequate resources made available for the needs uncovered. Improved training for practice nurses in assessment is needed. Effectiveness of the checks must be monitored. If most unmet need falls in particular high risk groups it would seem sensible to modify the annual check to target these groups.
European Commission orders France to lift ban on acne pill
Authors: S. Arie
Journal: BMJ (2013)

France has been forced to allow sales of Bayer’s acne pill Diane-35 despite its concerns over possible fatal side effects, after the European Commission ruled that the drug was safe.

Sales of Diane-35 (known as Dianette in the United Kingdom) were banned in France in May amid concerns that the drug, which contains cyproterone and ethinyestradiol, could cause thrombosis and pulmonary embolism. The drug …
Medicare's Readmissions-Reduction Program — A Positive Alternative
Authors: Robert A. Berenson, Ronald A. Paulus, Noah S. Kalman
Journal: New England Journal of Medicine (2012)

The Affordable Care Act's financial penalty for "excessive" readmissions may be too weak to overcome the substantial counterincentives currently at work. But a "warranty" payment would provide a stronger business case for hospitals to get with the program.
High negative predictive value diagnostic strategies for the reevaluation of early antifungal treatment: A multicenter prospective trial in patients at risk for invasive fungal infections
Authors: Lilia Hasseine, Sophie Cassaing, Florence Robert-Gangneux, Judith Fillaux, Pierre Marty, Jean-Pierre Gangneux, Anne Sirvent, Véronique Mondain, Hervé Hyvernat, Eric Rosenthal, Olivier Cointault, Laurence Lavayssière, Bernard Georges, Antoine Berry, Sophie de Guibert, Stanislas Nimubona, Matthieu Revest, Pierre Tattevin
Journal: Journal of Infection (2015)
SOME NOTES ON THE BIOLOGICAL DETERMINATION OF THE ERYTHEMA-DOSE OF X-RAYS IN "r" UNITS.*
Authors: W. N. GOLDSMITH
Journal: British Journal of Dermatology (1939)

Journal Article SOME NOTES ON THE BIOLOGICAL DETERMINATION OF THE ERYTHEMA‐DOSE OF X‐RAYS IN “r” UNITS. Get access W. N. GOLDSMITH W. N. GOLDSMITH London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 51, Issue 3, 1 March 1939, Pages 126–131, https://doi.org/10.1111/j.1365-2133.1939.tb10660.x Published: 01 March 1939
Modernising Medical Careers, Medical Training Application Service, and the Postgraduate Medical Education and Training Board: time for the emperors to don their clothes
Authors: Morris Brown, Nick Boon, Nick Brooks, Edwina Brown, John Camm, Mark Caulfield, Edwin Chilvers, John Gibson, Ashley Grossman, Alistair Hall, George Hart, Tony Heagerty, Philip Home, Humphrey Hodgson, Richard Horton, Richard Hughes, Kay-Tee Khaw, John Lazarus, David Leaper, Peter McCollum, John Monson, Stephen O'Rahilly, Brian Rowlands, Julian Scott, Robert Sutton, Roy Taylor, Hugh Watkins, Nick Wright, George Griffin
Journal: The Lancet (2007)
Expression of the Splicing Factor Gene SFRS10 Is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis
Authors: Jussi Pihlajamäki, Carles Lerin, Paula Itkonen, Tanner Boes, Thomas Floss, Joshua Schroeder, Farrell Dearie, Sarah Crunkhorn, Furkan Burak, Josep C. Jimenez-Chillaron, Tiina Kuulasmaa, Pekka Miettinen, Peter J. Park, Imad Nasser, Zhenwen Zhao, Zhaiyi Zhang, Yan Xu, Wolfgang Wurst, Hongmei Ren, Andrew J. Morris, Stefan Stamm, Allison B. Goldfine, Markku Laakso, Mary Elizabeth Patti
Journal: Cell Metabolism (2011)
Computers in audit: servants or sirens.
Authors: A N Hamlyn
Journal: BMJ (1991)

against pertussis infection have been determined.Serum antibody assays merely indicate that a subject has or has not responded to antigens considered to be important and allows comparison between groups of subjects at various times after vaccination or in response to different schedules.We believe that this is a valid approach when the same whole cell vaccine is used for each group.
Methodological Issues in Trials of Acupuncture—Reply
Authors: Joannie Shen
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mitral Valve Repair for Patients With Pure Mitral Insufficiency
Authors: Jerome Harold Kay
Journal: JAMA (1976)

Mitral valve repair rather than replacement was performed in 133 of 183 patients (73%) with considerable mitral valve insufficiency requiring surgery. There were seven operative deaths (5%) and 16 late deaths in the 133 patients followed up from 1 to 15 years. Only four of the late deaths were possibly related to the underlying valvular heart disease. Repair is preferable to replacement with present-day mitral valve prostheses. (<i>JAMA</i>236:1584-1586, 1976)
A GLANCE AT SOME RELATIONS OF DENTISTRY TO GENERAL MEDICINE.
Authors: GEO. F. EAMES
Journal: JAMA (1898)

The average dentist not only fails to recognize many indications which call for systemic treatment, but fails to see his need of such recognition. He still jumbles medical terms. His practice is largely empirical. He sees in part, but acts as one comprehending all; he gives advice to his fellow practitioners more freely than he would if he knew more. If a new drug is advertised he tries it a few times, and immediately writes an article on it. He treats all forms of pyorrhea by scraping the teeth, but the deposit continues to accumulate, and the scraping is repeated. He treats sensitive dentine by the application of obtundents, and never dreams of prophylaxis or the correction of the underlying cause. The teeth under certain conditions decay with great rapidity, and extra dollars are received for extra plugs inserted. The teeth are stained and eroded, only to be met with
Diagnosis of Horseshoe Kidney on Technetium-99m Hepatobiliary Scintigraphy
Authors: ALKA KUMAR, DIEU H. PHAM, HARRY MEINDOK, SHASHI AGGARWAL
Journal: Clinical Nuclear Medicine (1993)

Horseshoe kidney is a common renal anomaly. The diagnosis is usually suggested by radiographs and confirmed with intravenous pyelography, ultrasonography, or computed tomography. Although scintigraphic studies are not usually used to make the initial diagnosis, this common anomaly (which is usually asymptomatic) might be first observed on radionuclide scans incidentally. This is a report on one such case of horseshoe kidney for which the diagnosis was first suggested on hepatobiliary scintigraphy performed for unrelated reasons
Bilateral fractures of femoral neck in patients with moderate renal failure receiving fluoride for spinal osteoporosis.
Authors: J C Gerster, S A Charhon, P Jaeger, G Boivin, D Briancon, A Rostan, C A Baud, P J Meunier
Journal: BMJ (1983)

Two patients with moderate renal failure sustained spontaneous bilateral hip fractures during treatment with fluoride, calcium, and vitamin D for osteoporosis. They had been taking sodium fluoride (40-60 mg/day) for 11 and 21 months, respectively. Histological examination of a specimen of the bone showed severe fluorosis in the first case, and quantitative analysis of bone showed osteomalacia and skeletal fluorosis in the other case. These abnormalities were considered to be the consequence of excessive retention of fluoride due to renal insufficiency. As bilateral femoral neck fractures are very rare these data suggest a causal link between fractures and fluoride in patients with renal failure. Thus fluoride should be given at a lower dosage, if at all, to patients with even mild renal failure.
Cardiovascular response to isometric exercise in normal adolescents.
Authors: W P Laird, D E Fixler, F D Huffines
Journal: Circulation (1979)

The purpose of this study was to document the cardiovascular response to submaximal isometric handgrip (IHG) exercise in 32 normal adolescents. Left ventricular (LV) dimensions and systolic time intervals were recorded using echocardiography; blood pressure was measured by sphygmomanometry both at rest and during IHG exercise at 25% maximum contraction. This level of isometric exercise produced significant (p less than 0.001) increases in mean heart rate, systolic, diastolic and mean blood pressures. Despite this response LV diastolic and systolic dimensions remained unchanged during exercise; hence, stroke volume remained constant. Cardiac index increased by 22% (p less than 0.001) due to the increase in heart rate. Systemic vascular resistance did not change significantly. LV ejection indices, including shortening fraction, mean Vcf and systolic time intervals also remained unchanged, except for an increase in LV ejection time index (p less than 0.025). These data indicate that the cardiovascular response to submaximal isometric exercise in normal adolescents is similar to that reported in adults. This study demonstrates that sustained isometric stress testing in adolescents is safe and provides normal hemodynamic values.
EVIDENCE ON THE GENESIS OF PEPTIC ULCER IN MAN
Authors: STEWART WOLF
Journal: JAMA (1942)

Recent studies have shown that prolonged continuous acceleration of acid secretion in the stomach by the repeated administration of histamine in beeswax results regularly in the development of duodenal ulcer in a wide variety of laboratory and domestic animals.1Somewhat earlier it was shown that in dogs the maintenance of hyperacidity by continuous stimulation of the vagus2or by continuous sham feeding3resulted in ulcer.  While all these stimuli seem to cause ulcer by a common mechanism, namely by effecting a continuous hypersecretion of acid in the stomach, not one of the three is ordinarily operative in human beings subject to ulcer. It was with the purpose of discovering some stimulus which results in definite, sustained acceleration of acid production and which may have been recurrent in the ordinary course of life in ulcer patients that our studies were undertaken. We found that day to day life
THE INFLUENCE OF EXPERIMENTAL THYROID INTOXICATION ON THE POTASSIUM, SODIUM, AND WATER CONTENT OF THE MYOCARDIUM
Authors: Eaton M. MacKay, H. C. Bergman
Journal: Journal of Clinical Investigation (1932)

Harrison et al. (1) analyzed samples of cardiac and skeletal muscle obtained from patients who had died of congestive heart failure and found them to be abnormally poor in potassium.It is their belief (2, 3) that this diminution in the potassium content is related to overwork and the attendant fatigue.The heart in experimental thyrotoxicosis seemed to offer a possible opportunity of examining the hypothesis in question under controlled conditions.In addition, the effect of thyroid intoxication on the potassium content of the greatly enlarged heart has an interest of its own.Thirty-six male albino rats 140 days old and 14 rats 100 days old were divided into two groups on the basis of body weight.For two weeks they all received a special diet described elsewhere (4).In
Cardiac Function in Septic Shock
Authors: JAMES V. SNYDER
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 December 1984Cardiac Function in Septic ShockJAMES V. SNYDER, M.D.JAMES V. SNYDER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-6-879_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Parker and colleagues (1) noted a paradox in their study of 20 patients with documented septic shock. Ten of thirteen survivors but none of seven nonsurvivors had an initial ejection fraction less than 0.4. Survivors' ventricular end systolic and end diastolic volumes were substantially increased (160 and 120 mL) with a normal stroke volume index (40 mL) but ejection fraction of only 0.32 at the end of the first day of sepsis. The end systolic and end diastolic volumes in the nonsurvivors were about 80 and 32...References1. PARKERSHELHAMERBACHARACH MJS. Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med. 1984;100:483-90. LinkGoogle Scholar2. MAMMANAHIROLEVITSKYTHOMASPLACHETKA RSSPJ. Inaccuracy of pulmonary capillary wedge pressure when compared to left atrial pressure in the early postsurgical period. J Thorac Cardiovasc Surg. 1982;84:420-5. CrossrefMedlineGoogle Scholar3. LEFCOESIBBALDHOLLIDAY MWR. Wedged balloon catheter angiography in the critical care unit. Crit Care Med. 1979;7:449-53. CrossrefMedlineGoogle Scholar4. PREWITTWOOD RL. Effect of sodium nitroprusside on cardiovascular function and pulmonary shunt in canine oleic acid pulmonary edema. Anesthesiology. 1981;55:537-41. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES V. SNYDER, M.D.Affiliations: Presbyterian-University Hospital of Pittsburgh Pittsburgh, PA 15213 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAlternatives to Intermittent Positive Pressure Ventilation (IPPV) 1 December 1984Volume 101, Issue 6Page: 879-879KeywordsEjection fractionSepsisShockStroke ePublished: 1 December 2008 Issue Published: 1 December 1984 PDF downloadLoading ...
Cancer- and Cancer Treatment–Associated Cognitive Change: An Update on the State of the Science
Authors: Tim A. Ahles, James C. Root, Elizabeth L. Ryan
Journal: Journal of Clinical Oncology (2012)

Cognitive changes associated with cancer and cancer treatments have become an increasing concern. Using breast cancer as the prototype, we reviewed the research from neuropsychological, imaging, genetic, and animal studies that have examined pre- and post-treatment cognitive change. An impressive body of research supports the contention that a subgroup of patients is vulnerable to post-treatment cognitive problems. We also propose that models of aging may be a useful conceptual framework for guiding research in this area and suggest that a useful perspective may be viewing cognitive change in patients with cancer within the context of factors that influence the trajectory of normal aging.
Effect of negative intrathoracic pressure on left ventricular outflow tract obstruction in muscular subaortic stenosis.
Authors: A J Buda, G W MacKenzie, E D Wigle
Journal: Circulation (1981)

To study the effect of respiration and negative intrathoracic pressure on the left ventricular outflow tract gradient in patients with muscular subaortic stenosis, we studied nine patients using various respiratory maneuvers at the time of cardiac catheterization. Deep inspiration decreased the left ventricular outflow tract gradient from 60 +/- 11 to 34 +/- 6 mm Hg (p less than 0.01) and decreased the left ventricular ejection time (corrected for heart rate) from 0.42 +/- 0.01 to 0.38 +/- 0.01 second (p less than 0.001). The Müller maneuver decreased the left ventricular outflow tract gradient from 69 +/- 13 to 7 +/- 3 mm Hg (p less than 0.001) and decreased the corrected left ventricular ejection time from 0.42 +/- 0.02 to 0.24 +/- 0.01 second (p less than 0.01). In keeping with this amelioration of left ventricular outflow tract obstruction, echocardiography showed a reduction or abolition of the systolic anterior motion of the anterior mitral leaflet, and auscultatory and phonocardiographic studies revealed a decrease or abolition of the apical systolic murmur. These findings indicate that negative intrathoracic pressure reduced the left ventricular outflow tract gradient in muscular subaortic stenosis. We believe that negative intrathoracic pressure produced these changes by increasing left ventricular afterload through an increase in left ventricular transmural pressure, resulting in a decrease in the left ventricular outflow tract obstruction. These observations provide an explanation for the decrease in pressure gradient that occurs on inspiration in patients with muscular subaortic stenosis.