tbuckley/cabot-search huggingface dataset:
Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet α granules and differentially released
Authors: Joseph E. Italiano, Jennifer L. Richardson, Sunita Patel-Hett, Elisabeth Battinelli, Alexander Zaslavsky, Sarah Short, Sandra Ryeom, Judah Folkman, Giannoula L. Klement
Journal: Blood (2007)
Generalized warts and immune deficiency
Authors: T.M.S. REID, N.G. FRASER, I.R. KERNOHAN
Journal: British Journal of Dermatology (1976)

A case of common variable hypogammaglobulinaemia with associated impairment of cell mediated immunity and severe wart virus infection is described. The defect of cell mediated immunity is thought to have predisposed this patient to the development of persistent wart infection which in turn grossly depressed the body's cellular immunity and thus allowed widespread dissemination of the warts. The rapid restoration of cell mediated immunity which followed the reduction in the antigenic load of wart virus by diathermy treatment was followed by the spontaneous regression of all the patient's warts. This unusual case may provide some insight into the complex relationship between wart virus infection and the immune system of the host.
TCT-868 Incidence, Predictors and Impact of Bleeding after Transcatheter Aortic Valve Implantation
Authors: Bogdan Borz, Eric Durand, Matthieu Godin, Christophe Tron, Pierre - Yves Litzler, Jean-Paul Bessou, Alexandre Canville, Alain Cribier, Helene Eltchaninoff
Journal: Journal of the American College of Cardiology (2012)
Engineering hybrid polymer-protein super-aligned nanofibers via rotary jet spinning
Authors: Mohammad R. Badrossamay, Kartik Balachandran, Andrew K. Capulli, Holly M. Golecki, Ashutosh Agarwal, Josue A. Goss, Hansu Kim, Kwanwoo Shin, Kevin Kit Parker
Journal: Biomaterials (2014)

Cellular microenvironments are important in coaxing cells to behave collectively as functional, structured tissues. Important cues in this microenvironment are the chemical, mechanical and spatial arrangement of the supporting matrix in the extracellular space. In engineered tissues, synthetic scaffolding provides many of these microenvironmental cues. Key requirements are that synthetic scaffolds should recapitulate the native three-dimensional (3D) hierarchical fibrillar structure, possess biomimetic surface properties and demonstrate mechanical integrity, and in some tissues, anisotropy. Electrospinning is a popular technique used to fabricate anisotropic nanofiber scaffolds. However, it suffers from relatively low production rates and poor control of fiber alignment without substantial modifications to the fiber collector mechanism. Additionally, many biomaterials are not amenable for fabrication via high-voltage electrospinning methods. Hence, we reasoned that we could utilize rotary jet spinning (RJS) to fabricate highly aligned hybrid protein-polymer with tunable chemical and physical properties. In this study, we engineered highly aligned nanofiber constructs with robust fiber alignment from blends of the proteins collagen and gelatin, and the polymer poly-ε-caprolactone via RJS and electrospinning. RJS-spun fibers retain greater protein content on the surface and are also fabricated at a higher production rate compared to those fabricated via electrospinning. We measured increased fiber diameter and viscosity, and decreasing fiber alignment as protein content increased in RJS hybrid fibers. RJS nanofiber constructs also demonstrate highly anisotropic mechanical properties mimicking several biological tissue types. We demonstrate the bio-functionality of RJS scaffold fibers by testing their ability to support cell growth and maturation with a variety of cell types. Our highly anisotropic RJS fibers are therefore able to support cellular alignment, maturation and self-organization. The hybrid nanofiber constructs fabricated by RJS therefore have the potential to be used as scaffold material for a wide variety of biological tissues and organs, as an alternative to electrospinning.
STUDIES ON THYMUS FUNCTION
Authors: Osias Stutman, Edmond J. Yunis, Robert A. Good
Journal: The Journal of Experimental Medicine (1972)

The immune functions of neonatally thymectomized C3Hf mice exposed only temporarily to thymus function show a progressive decay with time in the absence of the thymus. The immune responses studied at different ages in the range of 100–600 days were: first-set rejection of H-2-compatible and incompatible skin allografts, second-set rejection of skin allografts, capacity of spleen cells to produce graft-versus-host reactions in F1 hybrids, resistance to infection with mouse hepatitis virus, and response of spleen cells to phytohemagglutinin in vitro. These long-term studies had the purpose of determining the duration of the restoration induced by thymus function when the mice were exposed only temporarily to it. Different models were used but the two basic ones were: (a) mice grafted intraperitoneally at 15 days of age with a syngeneic thymus that was removed surgically at 10, 20, or 30 days after grafting, and (b) mice grafted at 15 days of age with allogeneic strain A thymoma or C57BL thymus, these representing situations in which there is spontaneous rejection of the restoring graft. In all the experimental models used, the animals were restored when tested at 100 days of age, but progressively became immunologically incapacitated at 200–300 days of age. From the more controlled experiments in which the restoring thymus graft was removed surgically, the following conclusions can be drawn. (a) A short exposure to a thymus graft can produce restoration of immune functions in neonatally thymectomized mice, but this restoration is not self-sustaining in the absence of the thymus and declines progressively with age. The decline usually starts at 200–300 days of age. (b) This was especially clear in experiments in which the same animal was tested twice in its lifetime for capacity to produce graft-versus-host reactions; these animals were competent at 100 days and became incompetent at 400 days of age. (c) The shortest period of thymic exposure studied was 10 days; if vascularization of the graft is taken into account, 2–3 days of thymic function are sufficient to produce restoration. (d) The immune decay observed in the thymectomized animals exposed temporarily to thymus was more profound than the physiological decay of immunity observed in control animals of similar age. (e) Of all the tests studied, the response of spleen cells to phytohemagglutinin was to be preserved the longest in animals exposed only temporarily to thymic function. The present results were interpreted in accordance with our previous findings indicating that a population of postthymic cells can be developed by temporary exposure of neonatally thymectomized animals to thymic function, but that this population is not self-sustaining in the absence of thymus and progressively decays by physiological attrition.
Long-term follow-up of patients undergoing closed transventricular mitral commissurotomy: A useful surrogate for percutaneous balloon mitral valvuloplasty?
Authors: Charanjit S. Rihal, Hartzell V. Schaff, Robert L. Frye, Kent R. Bailey, LaVon N. Hammes, David R. Holmes
Journal: Journal of the American College of Cardiology (1992)
Phonocardiographic Differentiation Between Aortic and Pulmonic Insufficiency.
Authors: Robert H. Schwab
Journal: Annals of Internal Medicine (1964)

s1 April 1964Phonocardiographic Differentiation Between Aortic and Pulmonic Insufficiency.Robert H. Schwab, M.D., John H. Killough, M.D., F.A.C.P.Robert H. Schwab, M.D.Search for more papers by this author, John H. Killough, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-712_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients presenting with high-pitched diastolic decrescendo murmurs along the left sternal border may have insufficiency of either the pulmonic or aortic valve. Theoretically, using phonocardiography, one should be able to ascertain which semilunar valve gives rise to the murmur by observing the relationship of the diastolic murmur to the aortic and pulmonic components of the second heart sound. If the diastolic murmur begins immediately with the aortic component, the aortic valve is the insufficient valve. However, if there is a relatively silent interlude between the aortic and pulmonic components of the second sound the murmur starts immediately with, or within... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1964Volume 60, Issue 4Page: 712-712KeywordsAortic valveHeart Issue Published: 1 April 1964 PDF DownloadLoading ...
Upright Posture and Postprandial Hypotension in Elderly Persons
Authors: Mathew S. Maurer
Journal: Annals of Internal Medicine (2000)

Background: Syncope and falls are common in elderly persons and often result from the interaction of multiple clinical abnormalities. Both orthostatic hypotension and postprandial hypotension increase in prevalence with age. Objective: To determine whether meal ingestion enhances orthostatic hypotension in elderly persons. Design: Controlled paired comparison. Setting: Clinical research center. Patients: 50 functionally independent elderly persons recruited from local senior centers (n = 47) and from patients hospitalized with an unexplained fall or syncope (n = 3) (mean age, 78 years [range, 61 to 96 years]). Twenty-five participants (50%) were taking antihypertensive medication. Measurements: Sequential head-up tilt-table testing at 60 degrees was performed before and 30 minutes after ingestion of a standardized warm liquid meal that was high in carbohydrates. Heart rate and blood pressure were continuously monitored. Results: Meal ingestion (P < 0.01) and time spent upright (P < 0.001) were significantly associated with systolic blood pressure, but no significant interaction was found between meal ingestion and time spent upright (P > 0.2). These findings suggest that the association between meal ingestion and head-up tilt-table testing were additive and not synergistic. However, the proportion of participants with symptomatic hypotension increased during head-up tilt-table testing after meal ingestion (12% during preprandial testing and 22% during postprandial testing). Symptomatic hypotension tended to occur more often and sooner after meal ingestion than before meal ingestion (P = 0.03). Conclusions: Meal ingestion and head-up tilt-table testing are associated with increasing occurrences of symptomatic hypotension. After meal ingestion and head-up tilt-table testing, 22% of functionally independent elderly persons had symptomatic hypotension.
Competence to Practice — Robbing Peter to Pay Paul — Legislation of Private Practice
Authors: John Lister
Journal: New England Journal of Medicine (1977)

Three years ago the medical profession in Britain set up a committee "to review the present methods of ensuring the maintenance of standards of continuing competence to practise and of the clinical care of patients, and to make recommendations." The report1 of this committee, recently published, reflects not only the difficulty of its task but also the difficulty in obtaining a consensus opinion from the many different medical disciplines represented in the committee's membership. It is therefore perhaps not surprising that the report is seen by the Times 2 as a defensive document, timid and vague in its recommendations. Nevertheless, the . . .
Antisense-mediated reduction in thrombospondin reverses the malignant phenotype of a human squamous carcinoma.
Authors: V Castle, J Varani, S Fligiel, E V Prochownik, V Dixit
Journal: Journal of Clinical Investigation (1991)

Thrombospondin (TSP) is a trimeric glycoprotein which is synthesized and incorporated into the extracellular matrix by a wide variety of cells. TSP is involved in a number of cellular processes which govern tumor cell behavior including mitogenesis, attachment, migration, and differentiation. To directly assess the role of TSP in tumor cell growth and spread, a human squamous carcinoma cell line, with high TSP production and an invasive phenotype, was transfected with a TSP cDNA antisense expression vector. Five unique transfected clones were obtained with reduced TSP production. Expression of the transfected antisense sequence in these clones was verified by a ribonuclease protection assay. These clones demonstrated reduced growth rates in vitro when compared with a vector transfected control. After subcutaneous inoculation into athymic mice, the antisense clones formed either no tumors or tumors that were slow growing and highly differentiated. This contrasted with the vector-transfected clone which produced poorly differentiated, rapidly growing, invasive tumors. Our results argue in favor of a direct role for TSP in determining the malignant phenotype of certain human tumors.
THE GALLBLADDER AS REVEALED BY THE ROENTGEN RAY
Authors: SIDNEY LANGE
Journal: JAMA (1925)

More than twenty years ago when Rieder gave the first bismuth meal, it was observed that the stomach was not located horizontally in the epigastrium, but that, in the average person, it hung vertically on the left side of the abdomen, its lower pole reaching to the level of the navel and usually below the navel. This observation was not immediately accepted by clinicians, because it did not seem to agree with the observations made, over a long period of years, by surgeons doing abdominal operations and by pathologists while making necropsies. The unique value and accuracy of roentgen-ray stomach visualization is now universally accepted, however.  The visualization of the gallbladder by the use of the tetra-iodophenolphthalein test, as brought out by Graham and his co-workers, promises to be an equally important milestone for clinical medicine. The oral administration now permits of universal application of this test without danger or
Celebrity's death from cancer resulted in increased calls to CancerBACUP
Authors: M. Boudioni, J. Mossman, A. L Jones, G. Leydon, K. McPherson
Journal: BMJ (1998)

EDITOR—It is known that a patient with cancer can be influenced in her choice of treatment by the choice made by a famous person with the same disease. When Nancy Reagan, the wife of the then American president, chose a mastectomy in 1987, there was a subsequent 25% decrease in the number of women choosing breast conserving surgery. 1 2 A celebrity's death can have a similar powerful effect. The death of Diana, Princess of Wales, resulted in unprecedented public and media response. 3 4 The death of Linda McCartney in April has also …
Antioxidant and triglyceride-lowering effects of vitamin E associated with the prevention of abnormalities in the reactivity and morphology of aorta from streptozotocin-diabetic rats
Authors: Çimen Karasu, Gülgön Ozansoy, Onur Bozkurt, Deniz Erdoğan, Suna Ömeroğlu
Journal: Metabolism (1997)
G20210A Mutation in Prothrombin Gene and Risk of Myocardial Infarction, Stroke, and Venous Thrombosis in a Large Cohort of US Men
Authors: Paul M. Ridker, Charles H. Hennekens, Joseph P. Miletich
Journal: Circulation (1999)

Background —A single base pair mutation in the prothrombin gene has recently been identified that is associated with increased prothrombin levels. Whether this mutation increases the risks of arterial and venous thrombosis among healthy individuals is controversial. Methods and Results —In a prospective cohort of 14 916 men, we determined the prevalence of the G20210A prothrombin gene variant in 833 men who subsequently developed myocardial infarction, stroke, or venous thrombosis (cases) and in 1774 age- and smoking status–matched men who remained free of thrombosis during a 10-year follow-up (control subjects). Gene sequencing was used to confirm mutation status in a subgroup of participants. Overall, carrier rates for the G20210A mutation were similar among case and control subjects; the relative risk of developing any thrombotic event in association with the 20210A allele was 1.05 (95% CI, 0.7 to 1.6; P =0.8). We observed no evidence of association between mutation and myocardial infarction (RR=0.8, P =0.4) or stroke (RR=1.1, P =0.8). For venous thrombosis, a modest nonsignificant increase in risk was observed (RR=1.7, P =0.08) that was smaller in magnitude than that associated with factor V Leiden (RR=3.0, P &lt;0.001). Nine individuals carried both the prothrombin mutation and factor V Leiden (5 controls and 4 cases). One individual, a control subject, was homozygous for the prothrombin mutation. Conclusions —In a large cohort of US men, the G20210A prothrombin gene variant was not associated with increased risk of myocardial infarction or stroke. For venous thrombosis, risk estimates associated with the G20210A mutation were smaller in magnitude than risk estimates associated with factor V Leiden.
TYROSINOSIS: A SEARCH FOR ADDITIONAL CASES
Authors: N. R. Blatherwick
Journal: JAMA (1934)

Medes<sup>1</sup>has described a condition in which a male patient was unable to metabolize tyrosine in a normal manner and has given the name of tyrosinosis to this error of metabolism. The patient was not capable of metabolizing tyrosine beyond the stage of<i>p</i>-hydorxyphenylpyruvic acid but retained the ability to oxidize homogentisic acid. The inability to metabolize the latter substance characterizes the condition of alcaptonuria. When I heard of this new error of metabolism, I agreed to make a search for additional cases. The urine of Medes' patient had reducing properties and also gave a positive Millon's reaction. I therefore subjected all urine specimens that showed a slight amount of reduction by Benedict's picrate method for sugar to an additional test for the reduction of phosphomolybdic acid. This was used as suggested by Medes, as follows: To 1 cc. of urine in a test tube is added 2
American Physicians in the Nineteenth Century: From Sects to Science.
Authors: William G. Rothstein
Journal: Annals of Internal Medicine (1973)

Paper edition, with a new preface, of a 1972 work. The author, a sociologist, explains how ...19th-century medicine did not disappear; it evolved into modern medicine...; and he discusses such topics as active versus conservative intervention, reciprocity between physicians and the public in adopt
Viral infection of the lung: Host response and sequelae
Authors: Jae-Kwang Yoo, Taeg S. Kim, Matthew M. Hufford, Thomas J. Braciale
Journal: Journal of Allergy and Clinical Immunology (2013)

Because of its essential role in gas exchange and oxygen delivery, the lung has evolved a variety of strategies to control inflammation and maintain homeostasis. Invasion of the lung by pathogens (and in some instances exposure to certain noninfectious particulates) disrupts this equilibrium and triggers a cascade of events aimed at preventing or limiting colonization (and more importantly infection) by pathogenic microorganisms. In this review we focus on viral infection of the lung and summarize recent advances in our understanding of the triggering of innate and adaptive immune responses to viral respiratory tract infection, mechanisms of viral clearance, and the well-recognized consequences of acute viral infection complicating underlying lung diseases, such as asthma.
Pruritic urticarial papules and plaques of pregnancy in triplet pregnancy
Authors: N.S. Goldberg
Journal: British Journal of Dermatology (1997)

Journal Article Pruritic urticarial papules and plaques of pregnancy in triplet pregnancy Get access N.S. Goldberg N.S. Goldberg 222 Westchester Avenue, White Planis, NY 10604. U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 137, Issue 1, 1 July 1997, Page 161, https://doi.org/10.1111/j.1365-2133.1997.tb03731.x Published: 01 July 1997
Unde Venis? (Where Have You Been?)
Authors: Myron G. Schultz
Journal: JAMA (1984)

When the practice of quarantine was first introduced in Europe, outbreaks of diseases such as smallpox, cholera, plague, and yellow fever that were thought to be introduced by travelers from abroad led to the creation of many draconian regulations. Ships arriving in ports were kept at a distance and travelers were detained in isolation for 40 days before they were allowed to proceed to their destinations. 1 The fear of imported disease contributed to provincialism and stifled trade and travel.  How fortunate we are today that this fear has been removed. Liberal international health regulations have replaced harsh quarantine measures. Smallpox has been eradicated from the world and cholera, plague, and yellow fever are now mainly limited to rural areas of developing countries. International trade has burgeoned and long-distance mass air travel, one of the most extraordinary phenomena of our times, has transformed society. In 1981, an estimated 290 million
Screening Strategies for Pancreatic Cancer in High-Risk Patients
Authors: Mark S. Talamonti
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Rationalising the management of swallowed coins in children.
Authors: M D Stringer, S N Capps
Journal: BMJ (1991)

To assess the management of swallowed coins in children and identify aspects that could be improved.Study of records of three hospital departments for 1986-90.Accident and emergency, radiology, and operating theatre departments in a children's hospital.50 children reported to have ingested coins.Radiological investigations performed, position of coin, symptoms of child, and surgical intervention.50 children were recorded to have swallowed coins during 1986-90. Five children had only chest radiography, five only abdominal radiography, and 40 had both. A coin was detected in the oesophagus in 15 children, six of whom had symptoms, and below the cardia in 26, none of whom had symptoms; no coin was seen in nine children. Eleven children had further abdominal radiographs despite the absence of gastrointestinal symptoms; one child had a coin removed from the stomach.Children are being unnecessarily exposed to radiation and surgical intervention, and a consensus on management of swallowed coins is needed. Most children require only a single chest and neck radiograph.