tbuckley/cabot-search huggingface dataset:
Trials of colony stimulating factors grow, so do applications, side effects
Authors: B. Merz
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Happy and successful 2003!
Authors: J R Kalden
Journal: Annals of the Rheumatic Diseases (2002)

Your journal and society continue to grow

This year the Annals enters its fourth year as the official journal of the European League Against Rheumatism, EULAR; in this role the journal flourishes. In the past few years the number of manuscripts submitted has almost doubled, the circulation quadrupled, and the impact of the journal increased considerably.

The editorial team was proud to learn that so many readers appreciated the change and (as they …
22 SPLEEN AND LIVER STIFFNESS MEASUREMENT CAN PREDICT CLINICAL COMPLICATIONS IN COMPENSATED CIRRHOTIC PATIENTS: A PROSPECTIVE STUDY
Authors: A. Colecchia, D. Mandolesi, A. Colli, G. Casaazza, R. Schiumerini, L. Marzi, L. Bacchi-Reggiani, G. Bonato, A.R. Di Biase, M. Taddia, L. Montrone, E. Scaioli, G. Mazzella, D. Festi
Journal: Journal of Hepatology (2013)
The Mtb Proteome Library: A Resource of Assays to Quantify the Complete Proteome of Mycobacterium tuberculosis
Authors: Olga T. Schubert, Jeppe Mouritsen, Christina Ludwig, Hannes L. Röst, George Rosenberger, Patrick K. Arthur, Manfred Claassen, David S. Campbell, Zhi Sun, Terry Farrah, Martin Gengenbacher, Alessio Maiolica, Stefan H.E. Kaufmann, Robert L. Moritz, Ruedi Aebersold
Journal: Cell Host & Microbe (2013)
Case 63-1961
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. Kibbee
Journal: New England Journal of Medicine (1961)

Presentation of Case* A fifty-five-year-old man entered the hospital because of headache and mental confusion. Four weeks before admission the patient began to have periodic occipital and nuchal pressure pain, which frequently was sharp and often more severe at night, interfering with sleep. A cervical collar afforded some relief; aspirin was of no benefit. Two weeks before entry the neck pain and headaches became generalized, increased in frequency and severity and were associated with periods of confusion, vomiting, stiffness of the neck and vertigo. On one occasion the vomitus was blood-streaked. He experienced progressive drowsiness, lethargy and confusion during the . . .
The occurrence of residual or recurrent squamous cell carcinomas in organ transplant recipients after curettage and electrodesiccation
Authors: Y.G.L. de Graaf, V.R. Basdew, N. van der Zwan-Kralt, R. Willemze, J.N. Bouwes Bavinck
Journal: British Journal of Dermatology (2006)

Organ transplant recipients frequently develop multiple squamous cell carcinomas (SCCs). Surgical excision and Mohs micrographic surgery are frequently used treatments for these carcinomas; however, curettage and electrodesiccation are a useful alternative in these patients.To evaluate the efficacy of curettage and electrodesiccation for the treatment of appropriately selected low-risk SCCs in organ transplant recipients at different sites.Between April 1989 and December 2004, 211 SCCs in 48 organ transplant recipients were treated by curettage and electrodesiccation. Only histologically confirmed SCCs were considered in this study. The charts of these patients were retrospectively reviewed and checked for the rate of residual or recurrent SCCs. The occurrence of residual or recurrent SCCs at different locations after treatment of SCCs with curettage and electrodesiccation was estimated with Kaplan-Meier survival analysis.The mean follow-up time after curettage and electrodesiccation of the individual SCCs was 50 months (median 41; range 3-186). In total, 13 residual or recurrent SCCs were observed in 10 patients. The overall rate of residual or recurrent SCCs was 6%, with 7% for SCCs on the dorsum of the hands or fingers, 11% for SCCs on the head and neck, 0% for the forearms, and 5% for the remaining nonsun-exposed areas (shoulder, legs). No major clinical or cosmetic adverse events were registered after treatment.In organ transplant recipients with many SCCs curettage and electrodesiccation can be a safe therapy for appropriately selected low-risk SCCs, with an acceptable cure rate.
The British Medical Association in Oxford
Authors: John Lister
Journal: New England Journal of Medicine (1963)

IN the City of Oxford, which is itself so full of contrast, with its ancient University on the one hand and the new industrial life on the other, the British Medical Association has this year held its hundred and thirty-first annual meeting. Like the City, the meeting was full of contrast, the first week being devoted to debating the business of the Association in the annual meeting of representatives, which has been described as the parliament of the profession, and the second week to scientific discussions. Between the meetings in both weeks the amenities of Oxford and its surrounding countryside . . .
What is internalised? Dialogic cognitive representations and the mediated mind
Authors: Charles Fernyhough
Journal: Behavioral and Brain Sciences (2005)

Two aspects of Tomasello et al.'s account would benefit from further elaboration: (1) the construction of dialogic cognitive representations through social interaction, and (2) the cognitive consequences of operating with such representations. Vygotskian ideas on internalisation and verbal mediation may help us better to understand how dialogic cognitive representations can transform human cognition.
Subcutaneous administration of hyaluronan reduces the number of infectious exacerbations in patients with chronic bronchitis.
Authors: P Venge, B Pedersen, L Håkansson, R Hällgren, G Lindblad, R Dahl
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Hyaluronan (HA) is a high molecular weight glycosaminoglycan found in large amounts in the skin, joints, and other organs. Previous studies have shown that HA stimulates neutrophil functions both in vitro and in vivo. The object of this study was to test the hypothesis that HA administration subcutaneously might reduce the number of bacterial infections in humans with an increased susceptibility to such infections. For this purpose we have studied 29 patients with chronic bronchitis and recurrent acute exacerbations of their disease. The patients were randomly separated into two groups. One group had HA for 6 mo followed by 6 mo of placebo, and the other group started with placebo treatment followed by HA. The treatment periods occurred during two consecutive winter periods. HA-treated patients had significantly fewer acute exacerbations (p = 0.01) than did placebo-treated patients. Likewise the consumption of antibiotics and other signs of bacterial infections were reduced. In the crossover study the placebo-treated patients again had much higher numbers of acute exacerbations than did the HA-treated patients (p < 0.0001). It is concluded that HA reduces the number of infectious exacerbations in patients with chronic bronchitis, possibly by enhancing cellular host defense mechanisms. HA is a new endogenous substance that can be used to stimulate host defense reactions and reduce the need of antibiotics. Before being recommended for clinical use, however, our results should be confirmed by further studies.
Topiramate can induce hypoadrenalism in patients taking oral corticosteroid replacement
Authors: K Jacob, P J Trainer
Journal: BMJ (2009)

A 35 year old woman was taking life long glucocorticoid (dexamethasone) and mineralocorticoid (fludrocortisone, Florinef, Squibb) replacement for congenital adrenal hyperplasia caused by 21-hydroxylase deficiency. She started taking topiramate (Topamax, Janssen-Cilag) in March 2005, and the dose was titrated to 100 mg daily for atypical seizures secondary to mesial temporal sclerosis.

Before starting topiramate she had been taking stable doses of dexamethasone (0.25 mg a day) and fludrocortisone (100 μg a day), with biochemical evidence of good control …
Abstract LB-178: Characterization of estrogen responses in breast cancer cell lines highlights ERα as an LRH-1 regulated gene
Authors: Paul T.R Thiruchelvam, Hui Hua, Chun Fui Lai, Andy Photiou, Fiona Kyle, Charles Coombes, Laki Buluwela, Simak Ali
Journal: Cancer Research (2010)

Abstract Discussion Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-178.
Angiotensin II Has Multiple Profibrotic Effects in Human Cardiac Fibroblasts
Authors: Hiroaki Kawano, Yung S. Do, Yasuko Kawano, Vaughn Starnes, Mark Barr, Ronald E. Law, Willa A. Hsueh
Journal: Circulation (2000)

Background —Angiotensin II (Ang II) is implicated in cardiac remodeling and is increasingly recognized for its profibrotic activity. Methods and Results —Because little is known about the direct cellular effects of Ang II on human cardiac fibroblasts, we isolated fibroblasts from ventricles of explanted human hearts and added Ang II (100 nmol/L) to determine its role in growth, extracellular matrix accumulation, and adhesion. To assess which Ang II receptor is involved, Ang II was added in the presence of irbesartan (10 μmol/L), a specific AT 1 receptor antagonist; PD 123319 (10 μmol/L), a specific AT 2 receptor antagonist, or divalinil (100 nmol/L), an AT 4 receptor inhibitor. In human ventricles (n=13), message levels of atrial natriuretic peptide and AT 1 receptor were inversely correlated, which suggests a decrease in AT 1 receptor expression with progressive heart failure. Northern analysis and fluorescence-activated cell sorting demonstrated AT 1 receptor in cultured human cardiac fibroblasts. Ang II increased mitogen-activated protein kinase activity and in DNA synthesis (5-fold, P &lt;0.01) stimulated a 2-fold increase in transforming growth factor-β 1 ( P &lt;0.05) mRNA levels at 2 hours and a 2-fold increase in laminin ( P &lt;0.05) and fibronectin ( P &lt;0.05) mRNA levels at 24 hours. Ang II also enhanced plasminogen activator inhibitor-1 expression, which inhibits metalloproteinases that degrade the extracellular matrix. All of these effects were inhibited by irbesartan but not PD 123319 or divalinil. In addition, Ang II increased cardiac fibroblast attachment to collagens I and III, which was associated with an increase in focal adhesion kinase activity. Conclusions —Activation of the AT 1 receptor in human heart promotes fibrosis. Ang II plays a novel role in stimulation of plasminogen activator inhibitor-1 expression and adhesion of cardiac fibroblasts to collagen.
Comparison of microRNA profiles of human periodontal diseased and healthy gingival tissues
Authors: Yu‐feng Xie, Rong Shu, Shao‐yun Jiang, Da‐li Liu, Xiu‐li Zhang
Journal: International Journal of Oral Science (2011)

MicroRNAs (miRNAs) have been demonstrated to play an important role in regulation of the immunoinflammatory response; however, the function of miRNAs in periodontal inflammation has not been investigated. The objective of this study was to explore the properties of miRNAs in periodontal inflammation by comparing miRNA profiles of inflamed and healthy gingival tissues. Gingival tissues were obtained from 10 periodontitis patients and 10 healthy subjects. After RNA extraction, miRNA profiles were analyzed by microarray, and expression levels of selected miRNAs were confirmed by real-time quantitative reverse transcription polymerase chain reaction (RT-PCR). Analyses using two computational methods, Targetscan and MicroRNA.org, were combined to identify common targets of these miRNAs. Finally, the individual miRNA expression levels of three toll-like receptor (TLR)-related miRNAs from inflamed and healthy gingival tissues were evaluated by RT-PCR. Ninety-one miRNAs were found to be upregulated and thirty-four downregulated over two-fold in inflamed gingival tissue compared with those in healthy gingival tissue. Twelve selected inflammatory-related miRNAs, hsa-miR-126*, hsa-miR-20a, hsa-miR-142-3p, hsa-miR-19a, hsa-let-7f, hsa-miR-203, hsa-miR-17, hsa-miR-223, hsa-miR-146b, hsa-miR-146a, hsa-miR-155, and hsa-miR-205 showed comparable expression levels by microarray and real-time quantitative RT-PCR analyses. In addition, the putative inflammation targets of these miRNAs were predicted, and three that were tested (hsa-miRNA-146a, hsa-miRNA-146b, and hsa-miRNA-155), showed significant differences between inflamed and healthy gingiva. This remarkable difference in miRNA profiles between periodontal diseased and healthy gingiva implicates a probable close relationship between miRNAs and periodontal inflammation. The data also suggest that the regulation of TLRs in periodontal inflammation may involve miRNA pathways.
Boxing in the Army-Reply
Authors: Robert W. Enzenauer
Journal: JAMA (1989)

In Reply.—  We anticipated the controversy our article might engender. The army's  mission is  preserve the fighting strength. We object to Dr Finney's suggestion that we made a giant leap to question boxing. Our concern is the health of the soldiers we are sworn to protect.  We do possess the special competence Dr Finney describes to assess boxing as military training. Two of us graduated from service academies (R.W.E., USMA; R.J.E., USNA) and experienced boxing's  benefits first hand. Our opinions come from more than merely a medical background. 1,2   A military boxing ban would withstand Dr Finney's scrutiny of logic. Medical criteria should be tempered by training considerations when evaluating any activity. However, that military boxing injuries can be disabling or fatal is indisputable.  War is a dangerous encounter; preparing for war is a dangerous occupation. Military training is often dangerous. However, valuable training does not have
In vitro culture of cells exfoliated in the urine by patients with diabetes mellitus.
Authors: C J Detrisac, R K Mayfield, J A Colwell, A J Garvin, D A Sens
Journal: Journal of Clinical Investigation (1983)

As an approach to facilitate the understanding of the progression of diabetic renal disease, we assessed the urine of diabetic patients and normal volunteers for the presence of cells that could be cultured in vitro. The results suggest that both normal control subjects and diabetic patients, without clinically detectable microangiopathy, exfoliate few culturable cells into the urine. In contrast, diabetics with documented retinopathy but without nephropathy exfoliate substantially higher numbers of culturable cells (5.2 cells/100 ml urine), whereas diabetics with both retinopathy and advanced nephropathy exfoliate even greater numbers of culturable cells (50.8 cells/100 ml urine). The cells that are exfoliated and culturable can be divided into five distinct cell types based on morphology at the light microscope level. The exfoliated cells proliferate at clonal density after isolation from urine and are epithelial in appearance. These data suggest that the culture of cells from urine might have diagnostic value as an early indicator of diabetic renal disease and provide a convenient, noninvasive new source of human kidney epithelial cells.
Acne severity grading: Determining essential clinical components and features using a Delphi consensus
Authors: Jerry Tan, Barat Wolfe, Jonathan Weiss, Linda Stein-Gold, Joseph Bikowski, James Del Rosso, Guy F. Webster, Anne Lucky, Diane Thiboutot, Jonathan Wilkin, James Leyden, Mary-Margaret Chren
Journal: Journal of the American Academy of Dermatology (2011)
Hepatitis Associated with a Coxsackie B5 Virus Infection During Late Pregnancy
Authors: William J. O'Shaughnessey
Journal: JAMA (1962)

THE FOLLOWING account concerns a female in her seventh month of pregnancy who suffered a severe infection with Coxsackie B5 virus involving multiple organ systems. The case was considered worthy of special comment because hepatic damage was present. In addition, the striking similarity of the clinical picture to that usually produced by Weil's disease was thought to be of unusual interest. Report of a Case A 21-year-old white female was admitted to Charity Hospital of Louisiana on Oct. 23, 1959, with a diagnosis of "meningitis." The patient was 7 months pregnant (gravida 6, para 5). She had been in good health until 7 days prior to admission, when she developed a generalized headache, malaise, and a low-grade fever. Her physician felt that she had "flu" and treated her with tetracycline, 250 mg. every 6 hours. Two days later she developed projectile vomiting without nausea. At this time she was admitted
Abstract 1257: Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism
Authors: Tae-Wook Chung, Taro Hitosugi, Jun Fan, Xu Wang, Ting-Lei Gu, Johannes L. Roesel, Titus Boggon, Zhuo (Georgia) Chen, Fadlo R. Khuri, Sumin Kang, Jing Chen
Journal: Cancer Research (2011)

Abstract Many tumor cells rely on aerobic glycolysis for their continued proliferation and survival, which is in part due to actively inhibited mitochondrial function. Myc and HIF-1 are believed to promote such inhibition by upregulating gene expression of pyruvate dehydrogenase kinase 1 (PDHK1), which phosphorylates and inactivates mitochondrial pyruvate dehydrogenase complex (PDC). However, how oncogenic signals activate PDHK1 to regulate cancer cell metabolism remains unclear. Here we report that oncogenic FGFR1 activates mitochondrial PDHK1 by tyrosine phosphorylation. FGFR1 directly phosphorylates PDHK1 at Y136, Y243 and Y244. Mutational, structural and biochemical studies revealed that phosphorylation at both Y243 and Y244, but not Y136 is required to promote ATP binding to PDHK1, which consequently facilitates PDHK1 binding to PDC scaffold to access substrate PDHA1. In contrast, Y136 phosphorylation may only function to enhance binding between PDHK1 and PDC. We also found that PDHK1 is commonly tyrosine phosphorylated by diverse oncogenic tyrosine kinases in different human cancers. Moreover, we generated cancer cells with stable knockdown of endogenous human PDHK1 and “rescue” expression of phosphorylation-deficient, catalytic hypomorph mouse PDHK1 mutants including Y134F and Y239/240F (mouse PDHK1 numberings correspond to human PDHK1 Y136F and Y243/244F, respectively). These “rescue” cancer cells demonstrated decreased cell proliferation under hypoxia, increased oxidative phosphorylation with decreased lactate production, and reduced tumor growth in xenograft nude mice. Our findings suggest that tyrosine phosphorylation activates PDHK1 to inhibit mitochondrial function, providing a metabolic advantage for tumor growth. This represents a common, short-term molecular mechanism underlying the active inhibition of mitochondrial function in tumor cells, in addition to the chronic changes that are believed to be regulated by Myc and HIF-1. Moreover, inhibition of PDHK1 attenuates tumor growth, suggesting that PDHK1 may serve as a therapeutic target in cancer treatment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1257. doi:10.1158/1538-7445.AM2011-1257
Marked Improvement in Left Ventricular Systolic Function 3 Months After Cessation of Excess Alcohol Intake
Authors: RODNEY J. HICKS, ROBIN D. LOW, L. BARRY ARKLES
Journal: Clinical Nuclear Medicine (1993)

Excessive alcohol ingestion is a recognized cause of reversible dilated cardiomyopathy. A case is reported of dilated cardiomyopathy associated with excessive alcohol consumption that was remarkable with respect to the rapidity and extent of normalization in left ventricular systolic function after cessation of alcohol consumption.
Mediterranean Diet, Lifestyle Factors, and 10-Year Mortality in Elderly European Men and Women
Authors: Kim T. B. Knoops, Lisette C. P. G. M. de Groot, Daan Kromhout, Anne-Elisabeth Perrin, Olga Moreiras-Varela, Alessandro Menotti, Wija A. van Staveren
Journal: JAMA (2004)

Dietary patterns and lifestyle factors are associated with mortality from all causes, coronary heart disease, cardiovascular diseases, and cancer, but few studies have investigated these factors in combination.To investigate the single and combined effect of Mediterranean diet, being physically active, moderate alcohol use, and nonsmoking on all-cause and cause-specific mortality in European elderly individuals.The Healthy Ageing: a Longitudinal study in Europe (HALE) population, comprising individuals enrolled in the Survey in Europe on Nutrition and the Elderly: a Concerned Action (SENECA) and the Finland, Italy, the Netherlands, Elderly (FINE) studies, includes 1507 apparently healthy men and 832 women, aged 70 to 90 years in 11 European countries. This cohort study was conducted between 1988 and 2000.Ten-year mortality from all causes, coronary heart disease, cardiovascular diseases, and cancer.During follow-up, 935 participants died: 371 from cardiovascular diseases, 233 from cancer, and 145 from other causes; for 186, the cause of death was unknown. Adhering to a Mediterranean diet (hazard ratio [HR], 0.77; 95% confidence interval [CI], 0.68-0.88), moderate alcohol use (HR, 0.78; 95% CI, 0.67-0.91), physical activity (HR, 0.63; 95% CI, 0.55-0.72), and nonsmoking (HR, 0.65; 95% CI, 0.57-0.75) were associated with a lower risk of all-cause mortality (HRs controlled for age, sex, years of education, body mass index, study, and other factors). Similar results were observed for mortality from coronary heart disease, cardiovascular diseases, and cancer. The combination of 4 low risk factors lowered the all-cause mortality rate to 0.35 (95% CI, 0.28-0.44). In total, lack of adherence to this low-risk pattern was associated with a population attributable risk of 60% of all deaths, 64% of deaths from coronary heart disease, 61% from cardiovascular diseases, and 60% from cancer.Among individuals aged 70 to 90 years, adherence to a Mediterranean diet and healthful lifestyle is associated with a more than 50% lower rate of all-causes and cause-specific mortality.