tbuckley/cabot-search huggingface dataset:
Bavaria threatens to reduce abortion access
Authors: S. Goldbeck-Wood
Journal: BMJ (1996)

In Germany, the cabinet for Bavaria has sent a bill to the state parliament that, if passed, would limit the type of physicians allowed to perform induced abortions and the income physicians can earn from performing them. Only qualified obstetrician-gynecologists would be allowed to perform induced abortion. Now other appropriately qualified physicians can perform induced abortions. The bill would allow only 25% of a physician's income to be derived from performing induced abortion. If the bill becomes law, the law could force some clinics to close as well as reduce the number of physicians who terminate pregnancy. In effect, it would reduce access to abortions. A Munich physician (who is not a gynecologist) and a colleague in Nuremberg now do 50% of all socially indicated induced abortions in Bavaria. State health insurance in Bavaria only covers medically indicated abortions. All the income of the Munich physician derives from performing induced abortions. Should the bill pass, he will have to close his practice. Passing of the bill will not reduce the number of induced abortions but greatly worsen induced abortion services in Bavaria. This physician has written a letter to colleagues and ministers that accuses Bavaria of not complying with federal law. He sees the bill as an unconstitutional attempt to pursue a conservative policy. In August 1995, Germany synthesized the liberal abortion law of the former East Germany with that of the more conservative abortion law of the former West Germany. The synthesized law went into effect on January 1, 1996. The Munich physician served as an expert advisor to the government-select committee for the unborn. The Bavarian cabinet believes the federal law is open to interpretation.
The effect of organo clay and adsorbed FeO3 nanoparticles on cells cultured on Ethylene Vinyl Acetate substrates and fibers
Authors: Hilana M. Lewkowitz-Shpuntoff, Mary C. Wen, Avtar Singh, Nicole Brenner, Richard Gambino, Nadine Pernodet, Rebecca Isseroff, Miriam Rafailovich, Jon Sokolov
Journal: Biomaterials (2008)
Hoax bomb calls and psychiatry
Authors: Sanju George
Journal: BMJ (2006)

informed about important harms through other sources.We believe that the information included with invitations should be more balanced, using absolute numbers to describe the likelihood of benefits and harms, 19 and applying to the same time span if possible (box 2).Furthermore, we suggest that the responsibility for the programmes should be separated from the responsibility for the information material and that consumer groups be involved in the process of developing balanced information material.We thank those who supplied material, Hazel Thornton for contact details for the UK screening programme, and Kay Dickersin for comments on our manuscript.Contributors and sources: We have previously evaluated information on mammography screening on websites and PCG was involved in a systematic review of the breast screening trials, which questioned the value of screening.Both
Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production
Authors: Yeon-Sook Choi, Hyun-Jung Choi, Jeong-Ki Min, Bo-Jeong Pyun, Yong-Sun Maeng, Hongryeol Park, Jihye Kim, Young-Myeong Kim, Young-Guen Kwon
Journal: Blood (2009)
Lessons to be learnt from other countries about mandatory child vaccination
Authors: D. Stefler, R. Bhopal
Journal: BMJ (2012)

Salisbury argues against mandatory vaccination in the UK and suggests that compulsion is not necessary if immunisation coverage is above a “sufficiently high” level.1

In 2010 we published a comparison of disease control systems, including childhood vaccination, between Scotland and Hungary.2 In 2007, vaccination coverage rates for …
158. Gene Therapy for Chronic Pain Control: Perspectives of HSV-1 Mediated Gene Transfer to Supraspinal Centres
Authors: Isabel Martins, Marta Pinto, Steven Wilson, Deolinda Lima, Isaura Tavares
Journal: Molecular Therapy (2005)

Subcutaneous application of Herpes Simplex Virus type 1 (HSV-1) vectors mediating enkephalin transfer to the sensory neurons of the dorsal root ganglia, were shown to induce analgesia and reduce hyperalgesic reactions. These results prompted to use these vectors in the treatment of chronic intractable pain and human clinical trials based on these approaches are expected in the near future. Since brainstem regions are major pain control centres, HSV-1 mediating gene transfer at supraspinal level could also represent a major breakthrough for pain relief. Taking this into consideration, our purpose is the activation of antinociceptive supraspinal centers and blockade of pronociceptive areas. Before attempting this, we studied the migration dynamics of a replication-defective HSV-1 vector containing the reporter gene lacZ, under control of the cytomegalovirus promoter, from the caudal ventrolateral medulla (VLM) and the dorsal reticular nucleus (DRt), respectively, antinociceptive and pronociceptive areas.
Effects of Client-Centered Psychotherapy for Personality Disorders Alone and in Combination with Psychopharmacological Treatment
Authors: Ludwig Teusch, Hildegard Böhme, Jobst Finke, Markus Gastpar
Journal: Psychotherapy and Psychosomatics (2001)

&lt;i&gt;Background:&lt;/i&gt; There is an increasing interest concerning the treatment of patients with personality disorders (PD) in data on the efficacy of psychotherapeutic strategies especially when combined with medication. &lt;i&gt;Methods: &lt;/i&gt;The efficacy of an inpatient client-centered treatment program (CCT) was studied prospectively in 142 patients with PD and additional depressive, anxiety or eating disorders (ICD-10). &lt;i&gt;Results:&lt;/i&gt; Significant improvements in depression, self-esteem and social adjustment were achieved up to discharge, which remained stable at the 1-year follow-up. The efficacy with regard to individual variables or the total result could not be further enhanced by a combination with psychopharmacological treatment (CCT + MED), consisting mainly of antidepressants. Within the subgroups of patients with socially deviant (F60.0–2), emotionally unstable/borderline (F60.3) and histrionic/narcissistic PD (F60.4, F60.8), CCT was significantly superior to CCT + MED in the reduction of depression (Bech-Rafaelsen Melancholia Scale ratings), whereas the response was enhanced by medication in the subgroup of patients with socially dependent ‘cluster C’ PD (F60.5–7). &lt;i&gt;Conclusions: &lt;/i&gt;The results are discussed with regard to client-centered therapeutic concepts and to the further development of differential combination strategies.
What are important outcomes of bariatric surgery? An in-depth analysis to inform the development of a core outcome set and a comparison between the views of surgeons and other health professionals (the BARIACT study)
Authors: James Hopkins, Noah Howes, Katy Chalmers, Katie Whale, Jelena Savovic, Karen Coulman, Alex Nicholson, James Byrne, Robert Whistance, Richard Welbourn, Robert Andrews, Jane Blazeby
Journal: The Lancet (2015)
Fertility society calls for investigation into UK regulator's action after search warrants are declared illegal
Authors: Clare Dyer
Journal: BMJ (2007)

NHS Employers, the organisation responsible for employment procedures in the NHS, defended its vetting practices this week after seven doctors and medical students-six in the United Kingdom and one in Australia-were held by police in connection with the failed car bombings in London and Glasgow.One doctor, Iraqi born Bilal Abdullah, who worked as a locum doctor at the Royal Alexandra Hospital, in Paisley, near Glasgow, was arrested at the scene of Saturday's attempt to blow up a jeep packed with gas cylinders at Glasgow airport.Another man detained at the scene with 90% burns is thought to be a junior hospital doctor.He is in the Royal Alexandra Hospital.Later that day, the 26 year old Jordanian born doctor Mohammed Asha and a 27 year old woman, thought to be his wife, were arrested in Sandbach, Cheshire, northwest England.Dr Asha, whose family comes originally from Palestine, had worked as a junior doctor at the Royal Shrewsbury Hospital and the Princess Royal Hospital, in Telford.In a statement NHS Employers said that all NHS hospitals "carry out rigorous checks before they appoint any member of staff, including verification of identity, qualifications, registration, and eligibility to work in the UK."The nature of their work means that staff are dealing with people who are vulnerable, and we need to be confident that patients are safe."It added, "While doing all they can to prevent unsuitable people taking up employment in the NHS, employers also have a duty to look after the rights of their staff, and this includes not discriminating against employees in any way on the grounds of their religion or belief." NHS defends vetting after doctors held for bombing bidsUK NEWS Economist says NICE should approve fewer costly drugs, p11 World NEWS �ost US surgeons in training get needlestic�� in�uries, few report them, p1� �ost US surgeons in training get needlestic�� in�uries, few report them, p1� , p1� bm�.comEgypt tightens ban on female genital mutilation after 1�� year old girl dies Egypt tightens ban on female genital mutilation after 1�� year old girl dies
Hemoglobins with Altered Oxygen Affinity
Authors: BRUCE M. SMALL
Journal: Annals of Internal Medicine (1976)

Comments and Correction1 August 1976Hemoglobins with Altered Oxygen AffinityBRUCE M. SMALL, M.S., M.D.BRUCE M. SMALL, M.S., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-2-255_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article by Lichtman, Murphy, and Adamson (Ann Intern Med 84:517-520, 1976) presents a useful technique for the detection of hemoglobins with altered oxygen affinity. However, the equation given for the determination of P50 from the observed oxygen tension, saturation, and pH is rather formidable and may be reduced in a few steps to:AS REC P50std = antilog(logPO2 - (7.40 - pH)/2 + (1/n) (logR) ), where R = (100 - SO2)/SO2, and all other symbols are as defined by Lichtman and associates.In this form the calculation is shortened somewhat, and also the contributions to...Reference1. LICHTMAN M, MURPHY M, and POGAL M: The use of a single venous blood sample to assess oxygen binding to hemoglobin. Br J Haematol 32:89-98, 1976 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BRUCE M. SMALL, M.S., M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1976Volume 85, Issue 2Page: 255-255KeywordsHemoglobinOxygen ePublished: 1 December 2008 Issue Published: 1 August 1976 PDF downloadLoading ...
Inherited Variants in the Chemokine <i>CCL2</i> Gene and Prostate Cancer Aggressiveness in a Caucasian Cohort
Authors: Tong Sun, Lee Gwo-Shu Mary, William K. Oh, Matthew L. Freedman, Mark Pomerantz, Kenneth J. Pienta, Philip W. Kantoff
Journal: Clinical Cancer Research (2010)

Abstract Purpose: Though C–C chemokine ligand 2 (CCL2) has been shown to play a pivotal role in prostate cancer tumorigenesis and invasion, the role of inherited variation in the CCL2 gene in prostate cancer progression and metastases remains unanswered. This study is aimed to determine the influence of CCL2 germline variants on prostate cancer aggressiveness. Experimental Design: We performed an association study between six single nucleotide polymorphisms (SNP) in the CCL2 gene and prostate cancer clinicopathologic variables in a large hospital-based Caucasian patient cohort (N = 4,073). Results: Genetic variation at CCL2 is associated with markers of disease aggressiveness. Three SNPs, each in strong linkage disequilibrium, are associated with a higher (&amp;gt;7) biopsy Gleason score: CCL2 −1811 A/G, −2835 A/C, and +3726 T/C (P = 0.01, 0.03, and 0.04, respectively). The CCL2 -1811 G allele is addionally associated with advanced pathologic stages in patients who underwent radical prostatectomy (P = 0.04). In haplotype analysis, we found that the frequency of a common haplotype, H5, was higher among patients with D'Amico good risk features (Ppermutation = 0.04). Conclusions: These results support the influence of CCL2 variants on prostate cancer development and progression. Clin Cancer Res; 17(6); 1546–52. ©2010 AACR.
Aortocoronary bypass grafting in a child with coronary artery obstruction due to mucocutaneous lymphnode syndrome: report of a case.
Authors: S Kitamura, Y Kawashima, T Fujita, T Mori, C Oyama
Journal: Circulation (1976)

A four-year-old boy with a myocardial infarct and total occlusion of the right coronary and the left anterior descending coronary arteries due to mucocoutaneous lymphnode syndrome (MCLS). confirmed by selective coronary arteriography, underwent successful double aortocoronary bypass grafting. Patency of the grafts was demonstrated by graft angiography and the improvement of the contractile pattern of the left ventricle was reflected by the increase in ejection fraction from 0.45 to 0.61. This is the first patient successfully treated by aortocoronary bypass grafting for coronary artery obstructive lesions due to MCLS. This experience has demonstrated the feasibility of surgical management in a child with coronary artery obstruction due to MCLS. However, there are unanswered questions regarding the fate of the saphenous vein graft in relation to the growth of a child. Long-term clinical and angiographic follow-ups are mandatory to determine the significance of this mode of surgical treatment for the sequela of MCLS.
Genetic influences on sex differences in outstanding mathematical reasoning ability
Authors: Ada H. Zohar
Journal: Behavioral and Brain Sciences (1996)

Abstract Sexual selection provides an adequate partial explanation for the difference in means between the distributions, but fails to explain the difference in variance, that is, the overrepresentation of both boys with outstanding mathematical reasoning ability (OMRA) and boys with mental retardation. Other genetic factors are probably at work. While spatial ability is correlated with OMRA, so are other cognitive abilities. OMRA is not reducible to spatial ability; hence selection for navigational skill is unlikely to be the only mechanism by which males have gained an advantage in OMRA.
Defibrillator Implantation Early after Myocardial Infarction
Authors: Gerhard Steinbeck, Dietrich Andresen, Karlheinz Seidl, Johannes Brachmann, Ellen Hoffmann, Dariusz Wojciechowski, Zdzisława Kornacewicz-Jach, Beata Sredniawa, Géza Lupkovics, Franz Hofgärtner, Andrzej Lubinski, Mårten Rosenqvist, Alphonsus Habets, Karl Wegscheider, Jochen Senges
Journal: New England Journal of Medicine (2009)

The rate of death, including sudden cardiac death, is highest early after a myocardial infarction. Yet current guidelines do not recommend the use of an implantable cardioverter-defibrillator (ICD) within 40 days after a myocardial infarction for the prevention of sudden cardiac death. We tested the hypothesis that patients at increased risk who are treated early with an ICD will live longer than those who receive optimal medical therapy alone.This randomized, prospective, open-label, investigator-initiated, multicenter trial registered 62,944 unselected patients with myocardial infarction. Of this total, 898 patients were enrolled 5 to 31 days after the event if they met certain clinical criteria: a reduced left ventricular ejection fraction (< or = 40%) and a heart rate of 90 or more beats per minute on the first available electrocardiogram (ECG) (criterion 1: 602 patients), nonsustained ventricular tachycardia (> or = 150 beats per minute) during Holter monitoring (criterion 2: 208 patients), or both criteria (88 patients). Of the 898 patients, 445 were randomly assigned to treatment with an ICD and 453 to medical therapy alone.During a mean follow-up of 37 months, 233 patients died: 116 patients in the ICD group and 117 patients in the control group. Overall mortality was not reduced in the ICD group (hazard ratio, 1.04; 95% confidence interval [CI], 0.81 to 1.35; P=0.78). There were fewer sudden cardiac deaths in the ICD group than in the control group (27 vs. 60; hazard ratio, 0.55; 95% CI, 0.31 to 1.00; P=0.049), but the number of nonsudden cardiac deaths was higher (68 vs. 39; hazard ratio, 1.92; 95% CI, 1.29 to 2.84; P=0.001). Hazard ratios were similar among the three groups of patients categorized according to the enrollment criteria they met (criterion 1, criterion 2, or both).Prophylactic ICD therapy did not reduce overall mortality among patients with acute myocardial infarction and clinical features that placed them at increased risk. (ClinicalTrials.gov number, NCT00157768.)
Sexual Identity Conflict in Children and Adults
Authors: H. Keith Fischer
Journal: JAMA (1974)

Verbatim data are presented from transsexual patients—children and adults—and their parents and partners. The emphasis is on men who wish to become women and to a lesser extent on women who wish to become men. The male "feels himself more woman than man," he "cannot bear to live as a man," seeking "full acceptance by society as a woman," requesting female hormones to bring his body contours closer to female proportions, pleading for "genital surgery to remove male anatomic insignia," and "a birth certificate designating female status." "Feminine boys" are sissies, and "masculine girls" are tomboyish. The former often dress in female clothing, are poor mixers, take feminine identity in their own fantasies, choose toys usually selected by girls, avoid rough-and-tumble play and sports, and show considerable interest in play acting. This pattern is frequently recognized by the child and his parents at or before age 5. Psychological test studies
The role of fatty acid metabolism and lipotoxicity in pancreatic β-cell injury: Identification of potential therapeutic targets
Authors: Haopeng Yang, Xuejun Li
Journal: Acta Pharmaceutica Sinica B (2012)

Over the last 20 years, intensive research has been focused on the specific mechanisms mediating the pancreatic β-cell injury. Both the decreased viability and the dysfunction of β-cells have become the key factors in the development of diabetes mellitus. Thus, it is of utmost importance to elucidate the discrete pathological changes in pancreatic β-cells within the context of the various lipotoxicity models. The goal of these studies is to generate evidence to improve not only the clinical treatment for diabetics, but also modulate the diet and activities of groups at high risk for diabetes. In this regard, we review the role of lipotoxicity in pancreatic β-cell injury and identify potential therapeutic targets in this cell model.
No overall progression and occasional repair of erosions despite persistent inflammation in adalimumab-treated rheumatoid arthritis patients: results from a longitudinal comparative MRI, ultrasonography, CT and radiography study
Authors: U. M. Dohn, B. Ejbjerg, A. Boonen, M. L. Hetland, M. S. Hansen, L. S. Knudsen, A. Hansen, O. R. Madsen, M. Hasselquist, J. M. Moller, M. Ostergaard
Journal: Annals of the Rheumatic Diseases (2010)

<h3>Aim</h3> To monitor joint inflammation and destruction in rheumatoid arthritis (RA) patients receiving adalimumab/methotrexate combination therapy using MRI and ultrasonography. To assess the predictive value of MRI and ultrasonography for erosive progression on CT and compare MRI/ultrasonography/radiography for erosion detection/monitoring. <h3>Methods</h3> Fifty-two erosive biological-naive RA patients were followed with repeated MRI/ultrasonography/radiography (0/6/12 months) and clinical/biochemical assessments during adalimumab/methotrexate combination therapy. <h3>Results</h3> No overall erosion progression or repair was observed at 6 or 12 months (Wilcoxon; p&gt;0.05), but erosion progressors and regressors were observed using the smallest detectable change cut-off. Scores of MRI synovitis, grey-scale synovitis (GSS) and power Doppler ultrasonography decreased after 6 and 12 months (p&lt;0.05), as did DAS28, HAQ and tender and swollen joint counts (p&lt;0.001). Patients with progression on CT had higher baseline MRI bone oedema scores. The RR for CT progression in bones with versus without baseline MRI bone oedema was 3.8 (95% CI 1.5 to 9.3) and time-integrated MRI bone oedema, power Doppler and GSS scores were higher in bones/joints with CT progression (Mann–Whitney; p&lt;0.05). With CT as the reference method, sensitivities/specificities for erosion in metacarpophalangeal joints were 68%/92%, 44%/95% and 26%/98% for MRI, ultrasonography and radiography, respectively. Median intraobserver correlation coefficient was 0.95 (range 0.44–0.99). <h3>Conclusion</h3> During adalimumab/methotrexate combination therapy, no overall erosive progression or repair occurred, whereas repair of individual erosions was documented on MRI, and MRI and ultrasonography synovitis decreased. Inflammation on MRI and ultrasonography, especially MRI bone oedema, was predictive for erosive progression on CT, at bone/joint level and MRI bone oedema also at patient level.
Malignant Mesothelioma: A Case Report From an Area With Endemic Pleural Calcification
Authors: Lazaros Sichletidis
Journal: JAMA (1987)

<h3>To the Editor.—</h3> It is known that in certain geographic areas of the world a considerable percentage of the population shows pleural calcifications that are not caused by asbestos exposure.<sup>1</sup>However, no increase in the incidence of malignant mesothelioma has been shown in these areas, except in the village of Karein Kappadokia in Turkey.<sup>2</sup> A similar problem was found to exist in northern Greece. Pleural calcifications were noted on chest roentgenograms of a large number of residents of three neighboring villages (Metsovo, Anilio, and Milia) after an epidemiologic study for tuberculosis in 1969. It is notable that there have never been either mines or asbestos industries located within 100 km of these villages. A recent study<sup>3</sup>showed that 28% of the population of this area had pleural calcifications. A case of malignant mesothelioma in a resident of this specific region with no known asbestos exposure is presented. <h3>Report</h3>
Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation
Authors: Thomas H. Vanderford, Chloe Slichter, Kenneth A. Rogers, Benton O. Lawson, Rend Obaede, James Else, Francois Villinger, Steven E. Bosinger, Guido Silvestri
Journal: Blood (2012)
Alcoholism and Liver Disease-Reply
Authors: Ralph S. Ryback
Journal: JAMA (1983)

<h3>In Reply.—</h3> Our prospective study was not designed to evaluate every possible combination of alcoholic and non-alcoholic liver disease. Consequently, some clinicians may think we have excluded "critically important" groups, ie, groups they would have included. Drs Boyer and Levin are concerned that we did not include a group of alcoholics with biopsy-verified nonalcoholic liver disease in our analysis. We have, in fact, seen six such patients who admitted to consuming a minimum of four to six drinks per day during the six months preceding their biopsy-based diagnosis of nonalcoholic liver disease. All six patients were classified as having alcoholic liver disease on the basis of the discriminant analysis, indicating that when liver-damaged patients consume relatively large amounts of alcohol, the resulting biochemical and hematologic alterations resemble those observed in patients with biopsy-verified alcoholic liver disease. This explanation is supported by the subsequent observation that when two of the six