tbuckley/cabot-search huggingface dataset:
Misoprostol and Nonsteroidal Anti-Inflammatory Drugs
Authors: Julie Ruzzo Moore
Journal: Annals of Internal Medicine (1996)

Letters1 June 1996Misoprostol and Nonsteroidal Anti-Inflammatory DrugsJulie Ruzzo Moore, RPh, MBAJulie Ruzzo Moore, RPh, MBASmithKline Beecham; Philadelphia, PA 19101Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-11-199606010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest Dr. Levine's recent editorial, in which he stated, “… I would prescribe low doses of NSAIDs such as ibuprofen and nabumetone, which induce less gastropathy” [1].A randomized, endoscopist-blinded, 12-week study compared the relative effects of nabumetone, ibuprofen, and ibuprofen plus misoprostol on the mucosa of the esophagus, stomach, and duodenum in elderly patients treated for osteoarthritis [2]. Patients were randomly assigned to receive ibuprofen, 600 mg four times daily (n = 53); ibuprofen, 600 mg four times daily, plus misoprostol, 200 µg four times daily (n = 58); or nabumetone, 1000 mg ...References1. Levine JS. Misoprostol and nonsteroidal anti-inflammatory drugs: a tale of effects, outcomes and costs [Editorial]. Ann Intern Med. 1995; 123:309-10. Google Scholar2. Roth SH, Tindall EA, Jain AK, McMahon FG, April PA, Bockow BI, et al. A controlled study comparing the effects of nabumetone, ibuprofen, and ibuprofen plus misoprostol on the upper gastrointestinal tract mucosa. Arch Intern Med. 1993; 153:2565-71. Google Scholar Author, Article, and Disclosure InformationAffiliations: SmithKline Beecham; Philadelphia, PA 19101 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1996Volume 124, Issue 11Page: 1015KeywordsDuodenumElderlyEsophagusGastroenterology and hepatologyIbuprofenMucous membranesNSAIDsOsteoarthritisStomachUlcers Issue Published: 1 June 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
P220 DEEP SEQUENCING ANALYSES OF MINORITY BASELINE POLYMORPHISMS AND PERSISTENCE OF EMERGING MUTATIONS IN HCV GENOTYPE 1-INFECTED PATIENTS TREATED WITH SIMEPREVIR
Authors: B. Fevery, K. Thys, V. Van Eygen, T. Verbinnen, E. Van Rossem, G. Picchio, S. De Meyer, O. Lenz
Journal: Journal of Hepatology (2014)
Severe Mitral Regurgitation with Normal Pulmonary Artery Wedge Pressures
Authors: LAWRENCE GOULD
Journal: Annals of Internal Medicine (1967)

Case Studies1 April 1967Severe Mitral Regurgitation with Normal Pulmonary Artery Wedge PressuresLAWRENCE GOULD, M.D., F.A.C.P., ALAN F. LYON, M.D., F.A.C.P.LAWRENCE GOULD, M.D., F.A.C.P., ALAN F. LYON, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-4-748 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe preoperative diagnosis of mitral regurgitation and the estimation of its degree rest, ultimately, on the angiographic demonstration of radiopaque dye in the left atrium after injection in the left ventricle. Nonetheless, the greater availability of pressure data from the pulmonary arteries, pulmonary wedge, and left atrium has led to the use of pressure alterations at these sites in the evaluation of mitral regurgitation. A patient with significant mitral insufficiency is expected to have pulmonary hypertension, a tall V wave, and reduced X descent in the pulmonary wedge and left atrium. While the interpretation of these pressures has been recognized...References1. BRAUNWALDAWE EWC: The syndrome of severe mitral regurgitation with normal left atrial pressure. Circulation 27: 29, 1963. CrossrefMedlineGoogle Scholar2. ROBERTSBRAUNWALDMORROW WCEAG: Acute severe mitral regurgitation secondary to ruptured chordae tendineae. Circulation 23: 58, 1966. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bronx, New YorkFrom the Medical Service of the Veterans Administration Hospital, Bronx, N. Y.Requests for reprints should be addressed to Lawrence Gould, M.D., Bronx Veterans Administration Hospital, Bronx, N. Y. 10468. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPredictive value of prominent pulmonary arterial wedge V waves in assessing the presence and severity of mitral regurgitationLeft atrial v waves following mitral valve replacement are not specific for significant mitral regurgitationSevere "Silent" Mitral RegurgitationLeft atrial size, pressure, and v wave height in patients with isolated, severe, pure mitral regurgitationLarge V waves in the pulmonary capillary wedge pressure tracing without mitral regurgitation: He influence of the pressure/volume relationship on the V wave sizeLimitations of pulmonary wedge V waves in diagnosing mitral regurgitationSevere Mitral Regurgitation with a Normal- Sized Left AtriumThe Use of Metaraminol in the Evaluation of Mitral Insufficiency 1 April 1967Volume 66, Issue 4Page: 748-752KeywordsAtrial fibrillationEndocarditisHypertensionLeft atriumLeft ventricleMedical servicesMitral insufficiencyPulmonary arteriesPulmonary hypertension Issue Published: 1 April 1967 PDF DownloadLoading ...
Cystatin C Deficiency Increases Elastic Lamina Degradation and Aortic Dilatation in Apolipoprotein E–Null Mice
Authors: Galina K. Sukhova, Bing Wang, Peter Libby, Jie-Hong Pan, Yaou Zhang, Anders Grubb, Kenneth Fang, Harold A. Chapman, Guo-Ping Shi
Journal: Circulation Research (2005)

The pathogenesis of atherosclerosis and abdominal aortic aneurysm involves substantial proteolysis of the arterial extracellular matrix. The lysosomal cysteine proteases can exert potent elastolytic and collagenolytic activity. Human atherosclerotic plaques have increased cysteine protease content and decreased levels of the endogenous inhibitor cystatin C, suggesting an imbalance that would favor matrix degradation in the arterial wall. This study tested directly the hypothesis that impaired expression of cystatin C alters arterial structure. Cystatin C–deficient mice (Cyst C −/− ) were crossbred with apolipoprotein E–deficient mice (ApoE −/− ) to generate cystatin C and apolipoprotein E–double deficient mice (Cyst C −/− ApoE −/− ). After 12 weeks on an atherogenic diet, cystatin C deficiency yielded significantly increased tunica media elastic lamina fragmentation, decreased medial size, and increased smooth muscle cell and collagen content in aortic lesions of ApoE −/− mice. Cyst C −/− ApoE −/− mice also showed dilated thoracic and abdominal aortae compared with control ApoE −/− mice, although atheroma lesion size, intimal macrophage accumulation, and lipid core size did not differ between these mice. These findings demonstrate directly the importance of cysteine protease/protease inhibitor balance in dysregulated arterial integrity and remodeling during experimental atherogenesis.
Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations
Authors: Daniela Cesana, Jacopo Sgualdino, Laura Rudilosso, Stefania Merella, Luigi Naldini, Eugenio Montini
Journal: Journal of Clinical Investigation (2012)

Gamma-retroviral/lentiviral vectors (γRV/LV) with self-inactivating (SIN) long terminal repeats (LTRs) and internal moderate cellular promoters pose a reduced risk of insertional mutagenesis when compared with vectors with active LTRs. Yet, in a recent LV-based clinical trial for β-thalassemia, vector integration within the HMGA2 gene induced the formation of an aberrantly spliced mRNA form that appeared to cause clonal dominance. Using a method that we developed, cDNA linear amplification-mediated PCR, in combination with high-throughput sequencing, we conducted a whole transcriptome analysis of chimeric LV-cellular fusion transcripts in transduced human lymphoblastoid cells and primary hematopoietic stem/progenitor cells. We observed a surprising abundance of read-through transcription originating outside and inside the provirus and identified the vector sequences contributing to the aberrant splicing process. We found that SIN LV has a sharply reduced propensity to engage in aberrant splicing compared with that of vectors carrying active LTRs. Moreover, by recoding the identified vector splice sites, we reduced residual read-through transcription and demonstrated an effective strategy for improving vectors. Characterization of the mechanisms and genetic features underlying vector-induced aberrant splicing will enable the generation of safer vectors, with low impact on the cellular transcriptome.
PTU-042 Appropriately Trained Registrars Are As Good As Consultants In Endoscopic Management Of Moderate-severe Upper Gastrointestinal Haemorrhage: Abstract PTU-042 Table 1
Authors: M McShane, R Hewett, G Sadler, A Poullis
Journal: Gut (2014)

<h3>Introduction</h3> The South West Thames region operates a unique regional gastrointestinal service covering 4 hospitals. Registrar endoscopists are assessed and signed off as competent in providing endoscopic haemostatic therapy before taking their place on the GI bleed rota, and are supported by an on-call consultant. We aimed to evaluate if there were any operator-dependent differences in outcomes of endoscopic procedures performed in cases of moderate-severe upper gastrointestinal haemorrhage between consultants and registrars <h3>Methods</h3> Data were recorded for all emergency OGDs performed at St. George’s Hospital, between 01/01/13 and 30/06/13, in patients presenting with haematemesis or melaena and requiring endoscopy. The Rockall score for each patient was calculated and plotted against mortality for the whole population, and then sub classified into consultant- or registrar-performed procedures. <h3>Results</h3> 110 procedures performed on 101 patients (41 female, 60 male, median age 71, age range 23–93, and an overall mortality of 29.7%) were analysed A direct relationship between an increasing Rockall score and mortality was demonstrated in both the overall population, and also in the registrar-performed procedures, inferring typical population characteristics. Mortality for registrar-performed procedures showed no appreciable difference to that of the overall patient population. <h3>Conclusion</h3> Descriptors for achieving competence in therapeutic endoscopy have yet to be defined by the JAG. However, provided local mechanisms for delivering training in, and assessment of, competence at providing endoscopic haemostatic therapy are robust, our findings support the use of a registrar-led out-of-hours GI bleed service. <h3>Disclosure of Interest</h3> None Declared.
Posterior Chamber Intraocular Lens Implantation during Diabetic Pars Plana Vitrectomy
Authors: Gregg T. Kokame, Harry W. Flynn, George W. Blankenship
Journal: Ophthalmology (1989)

Combined cataract removal, posterior chamber intraocular lens (PC IOL) implantation, and pars plana vitrectomy were performed in 15 diabetic patients who presented with coexisting cataract and vitreoretinal complications from proliferative diabetic retinopathy (PDR). Posterior chamber IOLs were placed anterior to the anterior lens capsule after pars plana lensectomy and vitrectomy in nine eyes, whereas extracapsular cataract extraction (ECCE) with PC IOL placement was performed before vitrectomy in six eyes. Panretinal laser endophotocoagulation was applied in 13 of the 15 eyes as an important part of the operative procedure. Because of. inactive diabetic retinopathy or satisfactory preoperative panretinal photocoagulation, 2 of the 15 eyes did not receive laser endophotocoagulation. Visual acuity was improved in 12 eyes and was similar to preoperative vision in 3 eyes. After a minimum of 6 months and a maximum of 28 months of follow-up, the visual results are the following: 20/40 or better (4 eyes), 20/50 to 20/200 (5 eyes), 20/400 to 5/200 (5 eyes), and hand motions (1 eye). Although 5 of the 15 eyes required secondary vitreoretinal procedures, neovascular glaucoma and complications attributable to the IOL did not occur. A recurrent postoperative retinal detachment (RD) developed with subsequent hypotony and rubeosis iridis in 1 of the 15 eyes.
Authors have missed gap between theory and reality
Authors: R. Neilson
Journal: BMJ (2008)

<h3>Objective</h3> We compared the efficacy and safety of ultrasound-guided haematoma block with that of procedural sedation and analgesia in patients with acute distal radial fracture reduction pain control. <h3>Methods</h3> This was a randomised clinical trial on adult patients conducted in two teaching hospitals. Patients received intravenous midazolam plus fentanyl in the procedural sedation and analgesia group, and fracture site injection of lidocaine 10% in the ultrasound guided haematoma block group. We measured pain scores before reduction, during reduction and 5, 10 and 15 min after reduction by a numeric rating scale, and patient and physician satisfaction by a four-level Likert scale. Time to discharge, early adverse effects and late complications were also compared. <h3>Results</h3> We enrolled 160 patients with distal radial fracture and randomised 143 patients into two groups (after excluding 17 patients). Pain was effectively controlled in both groups. Pain scores had no statistically significant difference before and during reduction and 5 and 15 min after reduction in the procedural sedation and analgesia and ultrasound guided haematoma block groups. Patient and physician overall satisfaction were similar in the two groups. Time to discharge was significantly lower in the ultrasound guided haematoma block group. Four patients (5.5%) in the procedural sedation and analgesia group showed early adverse effects. No patient in either group showed any late complications. <h3>Conclusions</h3> Ultrasound guided haematoma block may be a safe and effective alternative to procedural sedation and analgesia. <h3>Trial registration number</h3> 201112308104N5.
Evaluation and surgical treatment of pulmonary atresia and intact ventricular septum in infancy.
Authors: A B Lewis, W Wells, G G Lindesmith
Journal: Circulation (1983)

The initial surgical approach to the infant with pulmonary atresia and intact ventricular (PA-IVS) is to establish an adequate source of pulmonary blood flow and, when possible, relieve right ventricular (RV) outflow obstruction. The selection of patients for pulmonary valvotomy, alone or in combination with a systemic-pulmonary arterial shunt, depends on the presence of an RV outflow tract and the adequacy of the RV chamber. To evaluate the size of the RV cavity in PA-IVS, an RV index (RVI) was developed using biplane angiographic measurements of the sum of the tricuspid valve annulus and the RV inflow and the RV outflow tracts. The RVI was normalized by relating it to the aortic diameter (Ao) at the diaphragm (RVI/Ao). The RVI/Ao was 13.5 +/- 1.4 in 20 control subjects and only 7.3 +/- 2.6 in 26 PA-IVS patients (p less than 0.001), and was within the normal range in only two of the 26. Since 1976, pulmonary valvotomy plus a Blalock-Taussig shunt has been performed in 10 infants, with one death. Serial cardiac catheterizations in five of nine survivors demonstrated substantial RV growth in all, with the RVI/Ao increasing from an average of 8.0 to 12.5. In contrast, patients who underwent a shunt alone had no change in RV cavity size. We conclude that pulmonary valvotomy may be performed successfully in most PA-IVS patients, but usually must be combined with a systemic-pulmonary shunt. In a small minority of patients, a normal RV cavity, as evidenced by an RVI/Ao greater than or equal to 11, appears to be sufficient to sustain adequate pulmonary blood flow after valvotomy alone. The RVI/Ao ratio is a simple method of quantitatively evaluating RV cavity size and is helpful in planning the initial surgical approach for these infants.
Effect of adenosine on coronary blood flow and its use as a diagnostic test for coronary artery disease
Authors: J D. Ogilby, J. Heo, A. S Iskandrian
Journal: Cardiovascular Research (1993)

Myocardial perfusion imaging during adenosine induced coronary hyperaemia is a highly sensitive method for diagnosing coronary artery disease. Most perfusion defects reflect heterogeneity in coronary blood flow in the territories of normal and diseased coronary arteries. Myocardial ischaemia can occur, however, due to subendocardial hypoperfusion and coronary artery steal. Evidence for myocardial ischaemia is more difficult to document in clinical than in experimental studies, and includes abnormalities in the ST segment, wall motion, haemodynamic variables, metabolism, and coronary blood flow responses. Using these indices, myocardial ischaemia may occur in some patients with coronary artery disease but it is not a prerequisite for the development of perfusion abnormalities and for the diagnosis of coronary artery during adenosine stress testing.
Dextran-Induced Anaphylaxis
Authors: George Bailey
Journal: JAMA (1967)

ANAPHYLACTIC reactions to polysaccharide plasma expanders, such as dextran, are rare, but with their increasing utilization must go an increasing awareness of their potential antigenicity. The first case of anaphylaxis to dextran was reported by Thorsen in 1944.<sup>1</sup>In the 20 years that have followed, there have been scattered reports of dextraninduced anaphylaxis.<sup>2,3</sup>The following is a detailed report of another such case in which antibody studies were done. <h3>Report of a Case</h3> An 18-year-old white boy entered Charity Hospital of Louisiana in New Orleans on Feb 2, 1966. He had sustained an open fracture of the upper third of his right femur in a motorcycle accident. His history revealed several episodes of urticaria following horseback riding. There was no personal history of bronchial asthma, rhinitis, or drug allergy. Family history revealed his father to be exquisitely sensitive to bee stings. The patient had suffered three past episodes
An Assessment of Local Curability of Endoscopic Surgery in Early Gastric Cancer without Satisfaction of Current Therapeutic Indications
Authors: Y. Amano, S. Ishihara, K. Amano, K. Hirakawa, K. Adachi, R. Fukuda, M. Watanabe, S. Fukumoto, H. Fujishiro, T. Imaoka
Journal: Endoscopy (1998)

Therapeutic endoscopy for early gastric cancer has been established with strict criteria for indications. In the present study, we evaluated the efficacy of endoscopic treatment in cases that did not fulfil the standard therapeutic criteria, consisting of well differentiating mucosal adenocarcinomas less than 2 cm in size and without an ulcer or a scar.Sixty nine early gastric cancers in 64 patients that did not fulfil the standard criteria were treated endoscopically, and a rate of cure was retrospectively assessed during a mean follow-up of 5.2 years. Endoscopic treatment consisted of mucosal resection or thermal methods, or both.Curative resection was achieved in 19/20 (95%) of cases which came into one of the following categories, all being well differentiated adenocarcinomas, less than 3.0 cm in size, without ulcer or the scar of an ulcer, with invasion limited to mucosal layer (depth m); tumors less than 2.0 cm, with an ulcer or scar, depth m; tumors less than 2.0 cm, without ulcer or scar, invading the submucosa but in which invasion was limited to the superficial portion (depth sm-1); and poorly differentiated tumors less than 1.0 cm in size, without an ulcer or scar, depth m. The rate of cure in this group was statistically similar to the cure rate of cases that fulfilled the standard criteria (98%).Our retrospective results suggest that the indications for curative treatment of early gastric cancer could be expanded. Prospective studies are required.
A case of intrinsic asthma.
Authors: G M Bell, M D Rawlins
Journal: BMJ (1977)

Case historyMr C D is a 70-year-old retired architect.Apart from a craniotomy in 1969 to extract a subdural haematoma, he has been fit all his life.He does not smoke, and has never had any respiratory tract symptoms until two years ago, when he started to develop a "wheeze."He improved initially with inhaled salbutamol, but his bronchospasm has worsened recently.
Management of Varicose Veins and Venous Insufficiency
Authors: Allen Hamdan
Journal: JAMA (2012)

Chronic venous disease, reviewed herein, is manifested by a spectrum of signs and symptoms, including cosmetic spider veins, asymptomatic varicosities, large painful varicose veins, edema, hyperpigmentation and lipodermatosclerosis of skin, and ulceration. However, there is no definitive stepwise progression from spider veins to ulcers and, in fact, severe skin complications of varicose veins, even when extensive, are not guaranteed. Treatment options range from conservative (eg, medications, compression stockings, lifestyle changes) to minimally invasive (eg, sclerotherapy or endoluminal ablation), invasive (surgical techniques), and hybrid (combination of ≥1 therapies). Ms L, a 68-year-old woman with varicose veins, is presented. She has had vein problems over the course of her life. Her varicose veins recurred after initial treatment, and she is now seeking guidance regarding her current treatment options.
Vitamin C Supplementation in the Elderly: A 17-month Trial in an Old Persons' Home
Authors: J. Andrews, M. Letcher, M. Brook
Journal: BMJ (1969)

Seventeen months' supplementation of the diet with vitamin C in elderly residents in an old persons' home failed to show any changes in sublingual lesions, which on histological examination proved to be aneurysmal dilatations of the venules. Nine months' supplementation of 40 to 80 mg. daily of vitamin C was necessary before the white-cell vitamin levels reached that found in younger people. There was a marked individual variation in response.
Bladder cancer mortality trends.
Authors: J M Davies
Journal: BMJ (1982)

Industrial bladder cancer SIR,-In a leading article on industrial bladder cancer (27 February, p 614) Robin Glashan claims that evidence from a study by Vineis et al purports to show that engineering workers using lubricating oil are at risk.'The paper by Vineis gives the results of a study into the incidence of larynx, bladder, and infantile tumours occurring among residents of towns in the province of Turin in the period 1965-9 and is in Italian.A careful reading of the paper, and the English abstract, reveals no reference to lubricating oil, greases, or lubricant in any form.I feel it is important to put this correction on record as there is no evidence either from this article or elsewhere that workers using lubricant oils are at any special risk of bladder cancer.
DIFFERENTIAL DIAGNOSIS IN TUBERCULOSIS OF THE EYE
Authors: WILLIAM C. FINNOFF
Journal: JAMA (1928)

When Michel, in 1890, emphasized the significance of tuberculosis as an etiologic factor in diseases of the eye, he was literally ridiculed by his colleagues. Since then there has been a marked change of opinion, and, at the present time, it is well known that any tissue of the eye may become the seat of a tuberculous process.  Histologic evidence that has been gathered from the study of microscopic sections of eyes has proved that tuberculosis is frequently responsible for ocular inflammations. Research workers have also been able to produce in animals all the clinical manifestations of tuberculosis of the eye as it is seen in the human being, and have fully substantiated Michel's contention.  In many instances, obscure inflammations of the eye are of tuberculous origin, and they may tax one's resources to the utmost in making a diagnosis, and unless one has tuberculosis in mind, the cause may
Physicians Prescribing “Medicine” for Enhancement: Why We Should Not and Cannot Overlook Safety Concerns
Authors: Katherine Drabiak-Syed
Journal: The American Journal of Bioethics (2011)

Click to increase image sizeClick to decrease image size Acknowledgments This publication was supported by a grant from the Richard M. Fairbanks Foundation to the IU Center for Bioethics and by NIH/NCRR grant RR025761. Its contents are solely the responsibility of the author and do not necessarily represent the official views of the National Institutes of Health.