tbuckley/cabot-search huggingface dataset:
Pregnancy-Related Thromboembolism
Authors: Leslea A. Brickner
Journal: Annals of Internal Medicine (1997)

Letters15 July 1997Pregnancy-Related ThromboembolismLeslea A. Brickner, MD, Kate A. Scannell, MD, and Lynn Ackerson, PhDLeslea A. Brickner, MDKaiser Permanente; Oakland, CA 94611Search for more papers by this author, Kate A. Scannell, MDKaiser Permanente; Oakland, CA 94611Search for more papers by this author, and Lynn Ackerson, PhDKaiser Permanente; Oakland, CA 94611Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-2-199707150-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We would like to point out a critical error by Friederich and associates [1] and to report on what we believe is the largest population study of the incidence of deep venous thrombosis and pulmonary embolism in the setting of delivered pregnancies (4 weeks postpartum). Our data suggest that the incidence is not only low but is similar to the incidence in closely age-matched nonpregnant women in another study [2].The annual 1.8% frequency of deep venous thrombosis in nonpregnant women 20 to 40 years of age cited by Friederich and colleagues is inaccurate. As listed in ...References1. Friederich PW, Sanson BJ, Simioni P, Zanardi S, Huisman MV, Kindt I, et al. Frequency of pregnancy-related venous thromboembolism in anticoagulant factor-deficient women: implications for prophylaxis. Ann Intern Med. 1996; 125:955-60. Google Scholar2. Nordstrom M, Lindblad B, Bergqvist D, Kjellstrom T. A prospective study of the incidence of deep-vein thrombosis within a defined urban population. J Intern Med. 1992; 232:155-60. Google Scholar3. Rutherford S, Montoro M, McGehee W, Strong T. Thromboembolic disease associated with pregnancy: an 11-year review [Abstract]. Am J Obstet Gynecol. 1991; 164(Suppl):286. Google Scholar Author, Article, and Disclosure InformationAffiliations: Kaiser Permanente; Oakland, CA 94611 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byICD-9-CM codes poorly indentified venous thromboembolism during pregnancy 15 July 1997Volume 127, Issue 2Page: 164KeywordsChartsDeep vein thrombosisHealth maintenance organizationsInternational Classification of DiseasesPregnancyPulmonary embolismThromboembolismUltrasound imagingVenous thromboembolismVentilation perfusion Issue Published: 15 July 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
CMR Quantification of Myocardial Scar Provides Additive Prognostic Information in Nonischemic Cardiomyopathy
Authors: Tomas G. Neilan, Otavio R. Coelho-Filho, Stephan B. Danik, Ravi V. Shah, John A. Dodson, Daniel J. Verdini, Michifumi Tokuda, Caroline A. Daly, Usha B. Tedrow, William G. Stevenson, Michael Jerosch-Herold, Brian B. Ghoshhajra, Raymond Y. Kwong
Journal: JACC. Cardiovascular imaging (2013)
The cytokeratin expression of cultured human foetal keratinocytes
Authors: ANNE M.OLIVER
Journal: British Journal of Dermatology (1990)

Skin samples taken from foetuses of 15–19 weeks gestational age and keratinocytes were cultured by the 3T3 feeder method or in serum-free MCDB 153 medium on 16 mm coverslips. Keratinocytes taken from paediatric circumcisions and patients undergoing plastic surgery were also cultured using the 3T3 feeder method. A panel of monoclonal antibodies against a number of cytokeratins and differentiation markers were used in the PAP technique to analyse the cells. Cryostat sections taken from the donor skin samples were stained simultaneously. Foetal skin expressed the cytokeratins 7, 13 and 19 that were not observed postnatally. This cytokeratin expression was maintained in both culture conditions and also observed in paediatric and adult keratinocytes. Cytokeratin 7 was expressed on a greater proportion of foetal cells than in vivo, whereas the expression of 13 and 19 decreased. All keratinocytes expressed vimentin, transferrin receptor and Ki67 (proliferating cell antigen), while a small proportion expressed involucrin throughout culture, indicating their high level of differentiation and proliferation. No differences were observed between low and high density cultures. Foetal keratinocytes cultured in MCDB 153 did not reach confiuence and stronger staining of differentiation markers was observed in these cells. These results show that the in vivo differences in cytokeratin expression of foetal and adult keratinocytes disappear in culture.
Initiative will fast-track vaccine for childhood diarrhoea in developing world
Authors: D. Singh
Journal: BMJ (2003)

A $30m (£18m; €28m) three year project to accelerate the development of a safe and effective rotavirus vaccine for the developing world was announced this week by the Global Alliance for Vaccines and Immunisations and the Vaccine Fund.

The project will be led by the Program for Appropriate Technology in Health, an international organisation that aims to improve the health of women and children. The programme's team will include public health experts from the World Health Organization, the Centers for …
Alcohol Consumption and the Incidence of Type 2 Diabetes
Authors: Sofia Carlsson, Niklas Hammar, Valdemar Grill, Jaakko Kaprio
Journal: Diabetes Care (2003)

OBJECTIVE—The aim of this study was to investigate alcohol consumption in relation to the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS—The study population consisted of 22,778 twins of the Finnish Twin Cohort. This cohort was compiled in 1975 and includes all same-sexed twins born in Finland before 1958. Information on alcohol, smoking, diet, physical activity, medical, and social conditions was obtained by questionnaires administered in 1975, 1981, and 1990. By record linkage to national registers of hospital discharge and prescribed medication, 580 incident cases of type 2 diabetes were identified during 20 years of follow-up. RESULTS—Moderate alcohol consumption (5–29.9 g/day in men and 5–19.9 g/day in women) tended to be associated with a reduced incidence of type 2 diabetes compared with low consumption (&amp;lt;5 g/day). The estimates were lower in overweight (BMI ≥25.0 kg/m2) subjects (relative risk 0.7, 95% CI 0.5–1.0 [men]; 0.6, 0.3–1.1 [women]). High alcohol consumption (≥20 g/day) was associated with an increased incidence of type 2 diabetes in lean women (2.9, 1.1–7.5) but not in overweight women or in men. In women, binge drinking was associated with an increased incidence of type 2 diabetes (2.1, 1.0–4.4). Analyses of alcohol-discordant twin pairs supported a reduced risk in moderate consuming twins compared with their low-consuming cotwins (odds ratio 0.5, 95% CI 0.2–1.5). CONCLUSIONS—The results of this study suggested that moderate alcohol consumption may reduce the risk of type 2 diabetes. On the other hand, binge drinking and high alcohol consumption may increase the risk of type 2 diabetes in women.
The MLL recombinome of acute leukemias
Authors: C Meyer, B Schneider, S Jakob, S Strehl, A Attarbaschi, S Schnittger, C Schoch, M W J C Jansen, J J M van Dongen, M L den Boer, R Pieters, M-G Ennas, E Angelucci, U Koehl, J Greil, F Griesinger, U zur Stadt, C Eckert, T Szczepański, F K Niggli, B W Schäfer, H Kempski, H J M Brady, J Zuna, J Trka, L L Nigro, A Biondi, E Delabesse, E Macintyre, M Stanulla, M Schrappe, O A Haas, T Burmeister, T Dingermann, T Klingebiel, R Marschalek
Journal: Leukemia (2006)
Circulatory Failure in Metastatic Carcinoma of the Lung
Authors: OLE STORSTEIN
Journal: Circulation (1951)

Four cases of extensive metastatic pulmonary carcinomatosis have been studied from the point of view of hemodynamics (cardiac catheterization) and pathology in order to evaluate the various factors in the pathogenesis of the subacute form of cor pulmonale. The author stresses the importance of distinguishing between the extensive destruction of lung tissue, leading to anoxemia, and the invasion of lung vessels by cancer cells, leading to pulmonary arterial hypertension and later to failure of the right ventricle.
Treatment of Steroid-Resistant Acute Graft-vs-host Disease by In Vivo Administration of an Anti—T-Cell Ricin A Chain Immunotoxin
Authors: Nancy A. Kernan
Journal: JAMA (1988)

The A chain of the toxin ricin has been conjugated by a disulfide bond to a murine monoclonal antibody that recognizes the CD5 (T,p67) antigen present on 95% of peripheral blood T lymphocytes. This immunotoxin was used to treat a patient with severe grade III-IV, steroid-resistant, acute graft-vs-host disease (GvHD) after an allogeneic, human leukocyte antigen—identical bone marrow transplant for acute myelogenous leukemia. Immunotoxin therapy produced a complete clinical response in the skin and gastrointestinal tract. The patient tolerated a 14-day course without symptoms or signs of toxic effects. After two days of therapy, circulating T cells could not be demonstrated by indirect immunofluorescence. After therapy, acute GvHD did not recur. However, seven months after therapy the patient demonstrated mild signs of chronic GvHD that were easily controlled with low-dose immunosuppressive therapy. These findings indicate that an anti—T-cell ricin A chain immunotoxin can be given safely for treatment of acute GvHD and may be an effective therapy for this significant posttransplant complication. (<i>JAMA</i>1988;259:3154-3157)
Hours of work, disasters, and safety
Authors: M. W Cooke
Journal: BMJ (1989)

servative treatment is therefore advised, whereas unimpacted-that is, dislocated-fractures need internal fixation-that is, surgery.Therefore, according to the principle of intention to treat, 22 patients with impacted fractures were excluded from the study, while 42 patients with dislocated fractures were included, although they were treated conservatively.The reason for conservative treatment of the 42 patients was in many cases recent myocardial infarction, whose importance was the subject of our study.This, however, could be evaluated only by following the intention to treat principle.The diagnostic criteria for myocardial infarction were those generally accepted.'It is not a previous myocardial infarction as such but a recent myocardial infarction-that is, within six months-that is generally held to be a serious risk factor.-2The relevant control group is composed of patients with similar surgical disease and a myocardial infarction more than six months before potential surgery.We believe that our design is good for estimating the surgical risk of a recent myocardial infarction, being in many ways closely comparable with a randomised controlled clinical trial.A randomised controlled clinical trial would obviously be unacceptable for ethical reasons.We agree that our mortality figures could have been put into perspective by comparison with a population matched for age and sex.We think, however, that mortalities between 9 and 16% a month speak for themselves.It concerns us that Drs Herrema and Milligan are concerned about our conclusions.According to our results, complex scores such as the Goldman index2 no longer need to be used to estimate patients' surgical risk.The only information now necessary about patients with previous or recent myocardial infarction is left ventricular function.
Nullius in Verba
Authors: Brendan C. Visser
Journal: JAMA Surgery (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Parasitic Disease as a Cause of Immunosuppression
Authors: Ruth S. Nussenzweig
Journal: New England Journal of Medicine (1982)

Parasitic infections, whether induced by protozoa (as in malaria and trypanosomiasis) or by helminths (as in schistosomiasis and filariasis) are among the most widespread and severe diseases of mankind. In the past 10 years, it has become increasingly evident that these parasites not only have direct, deleterious effects on the host but also affect the host's immune system by impairing the immune response to parasite-unrelated antigens.Williamson and Greenwood1 were among the first investigators to recognize the potential importance of this phenomenon in their studies in areas of high malaria endemicity. They observed that the immune response to vaccination with . . .
The Need for Management Capacity to Achieve VISION 2020 in Sub-Saharan Africa
Authors: Susan Lewallen, Amir Bedri Kello
Journal: PLoS Medicine (2009)

N Sub-Saharan Africa has the highest regional burden of blindness and visual impairment in the world.N More clinically trained manpower alone will not be sufficient to meet eye care needs and will not guarantee productive services.N Management systems run by professional nonclinical
The prognostic impact of autologous stem cell transplantation in patients with chronic lymphocytic leukemia: a risk-matched analysis based on the VH gene mutational status
Authors: Peter Dreger, Stephan Stilgenbauer, Axel Benner, Matthias Ritgen, Alexander Kröber, Michael Kneba, Norbert Schmitz, Hartmut Döhner
Journal: Blood (2003)
THE ADMINISTRATION OF SANITARY LAWS.
Authors: WM. P. MUNN
Journal: JAMA (1898)

The complicated relations existing in most municipal governments between the different departments and bureaus seem to make it essential that the health department, bureau or board should have a legal advisor of its own. Take, for example, a city in which, as in Denver, the boards and officers comprising the various divisions and sub-divisions of the executive force are appointed by different officers, and own no allegiance to a single and responsible head. It can readily be seen how it happens, as it often does, that one department seeks to carry out a plan of action, which in some particulars will conflict with the regulations and activities of another department, and there is no ready method of harmonizing and unifying the efforts of the departments. For example, in most, and perhaps in all cities, the construction of sanitary sewers, or of a waterworks system would devolve upon the officers having
Response-guided telaprevir therapy in prior relapsers? The role of bridging data from treatment-naïve and experienced subjects
Authors: Jiang Liu, Pravin R. Jadhav, Shashi Amur, Russell Fleischer, Thomas Hammerstrom, Linda Lewis, Lisa Naeger, Jule O'Rear, Michael Pacanowski, Sarah Robertson, Shirley Seo, Greg Soon, Debra Birnkrant
Journal: Hepatology (2012)

The purpose of this report is to illustrate the US Food and Drug Administration's rationale for approving response-guided therapy (RGT) for telaprevir (TVR) in combination with pegylated interferon-α and ribavirin (P/R) for the treatment of adults with genotype 1 chronic hepatitis C who were prior relapsers. RGT was prospectively evaluated in two registration trials of treatment-naïve subjects. In these studies, RGT allowed subjects who achieved undetectable hepatitis C virus RNA from weeks 4 and 12, known as extended rapid virologic response (eRVR), to stop all treatments at 24 weeks. A patient without eRVR received an additional 36 weeks of P/R after 12 weeks of a TVR triple regimen (total of 48 weeks). However, RGT in prior P/R relapsers was not prospectively evaluated. Empirical cross-trial data indicated high sustained virologic response rates (>90%) in prior relapsers achieving eRVR, irrespective of P/R duration (24 or 48 weeks). Further analyses demonstrated that interferon responsiveness does not change in P/R-experienced subjects with a second round of P/R. The comparability in interferon responsiveness across treatment courses allowed us to bridge data between treatment-naïve and P/R-experienced subjects to support the approval of RGT in prior relapse subjects. (HEPATOLOGY 2013)
Living with Parkinson's disease---a child's perspective
Authors: L. Rees
Journal: BMJ (2002)

I was 10 years old when my mother came back from a large London teaching hospital having been given the diagnosis of young onset Parkinson's disease. She was 46 years of age. She had made the diagnosis herself before this appointment. She was first told it by medical students when, during a consultant led teaching session, she had been asked to walk across the front of a lecture theatre to show the characteristic gait. She was humiliated, and I was angry. That was when I decided to become a doctor myself.

Fortunately, young onset Parkinson's disease is not common. Most people are aware of the devastating symptoms—the tremor, the poverty of movement, the falls, …
DNA Probes for Papillomavirus Strains Readied for Cervical Cancer Screening
Authors: Beverly Merz
Journal: JAMA (1988)

NEW PAPILLOMAVIRUS TESTS are ready to come to the aid of the standard Papanicolaou test in screening for cervical cancer. The new tests, which detect the strains of human papillomavirus (HPV) most commonly associated with human cervical cancer, are designed to be used as an adjunct to rather than as a replacement for the Papanicolaou smear. Their developers say that they can be used to indicate a risk of developing cancer in women whose Papanicolaou smears indicate mild cervical dysplasia, and, eventually, to detect papillomavirus infection in "normal" Papanicolaou smears. The rationale for HPV testing is derived from a growing body of evidence that HPV is a major factor in the etiology of cervical cancer. Two strains, HPV-16, and HPV-18, have been identified in 60% of cervical carcinomas. Three others, HPV-31, HPV-33, and HPV-35, have been identified in 25%. Two other papillomavirus strains, HPV-6 and HPV-11, are associated with the
The ???Hot??? Patella
Authors: MICHAEL S. KIPPER, NAOMI P. ALAZRAKI, DAVID H. FEIGLIN
Journal: Clinical Nuclear Medicine (1982)

Increased patellar uptake on bone scans is seen quite commonly but the possible or probable etiologies of this finding have not been previously well described. A review of 100 consecutive bone scans showed that the incidence of bilateral “hot” patellae is 15%. Identified etiologies include osteoarthritic degenerative disease (35%), fracture, possible metastatic disease, bursitis, Paget's disease, and osteomyelitis. The value of careful history, physical examination, and radiographs is stressed.
Management of Heel Pain
Authors: Alan E. Singer
Journal: JAMA (1978)

<h3>To the Editor.—</h3> I read the remarks by Dr Giannestras in QUESTIONS AND ANSWERS. My interest in the topic of heel pain stems from my longstanding association with the Diabetic Foot Clinic at Georgetown University Hospital and through my position as clinical instructor of surgery in the Department of Orthopedics at Georgetown University Medical School. Dr Giannestras states that the heel pain in question is "probably circulatory in origin" because the pain is present when the patient awakens in the morning and disappears as soon as ambulation is begun. He further states that since the patient is mildly diabetic, there is probably some degree of peripheral vascular disease present. Further along it is suggested that the patient try applying a heat pad to the foot as a form of therapy for relief of the symptoms. It has been my experience that heel pain that is present on arising in the
Stroke Volume and Cardiac Output in Normotensive Children and Adults
Authors: Giovanni de Simone, Richard B. Devereux, Stephen R. Daniels, GianFrancesco Mureddu, Mary J. Roman, Thomas R. Kimball, Rosanna Greco, Sandra Witt, Franco Contaldo
Journal: Circulation (1997)

Background Relations between organs and body size are not linear but rather follow allometric (growth) relations characterized by their powers (exponents). Methods and Results Stroke volume (SV) by M-mode echocardiography was related to height, weight, body surface area (BSA), and ideal BSA (derived from ideal body weight for given height) in 970 normotensive individuals (1 day to 85 years old; 426 &lt;18 years old; 204 overweight to obese; 426 female). In normal-weight children, adults, and the entire population, SV was related by allometric relations to BSA (power=0.82 to 1.19), body weight (power=0.57 to 0.71), and height (power=1.45 to 2.04) (all P &lt;.0001). Relations of cardiac output to measures of body size had lower allometric powers than those for SV in the entire population (0.41 for body weight, 0.62 for BSA, and 1.16 for height). In overweight adults, observed SVs were 17% greater than predicted for ideal BSA, a difference that was approximated by normalization of SV for height to age-specific allometric powers. Similarly, observed cardiac output was 19% greater than predicted for ideal BSA, a difference that was accurately detected by use of cardiac output/height to age-specific allometric powers but not of BSA to the first power. Conclusions Indexations of SV and cardiac output for BSA are pertinent when the effect of obesity needs to be removed, because these indexations obscure the impact of obesity. To detect the effect of obesity on LV pump function, normalization of SV and cardiac output for ideal BSA or for height to its age-specific allometric power should be practiced.
alpha-Fucose-mediated binding and degradation of tissue-type plasminogen activator by HepG2 cells.
Authors: K A Hajjar, C M Reynolds
Journal: Journal of Clinical Investigation (1994)

The glycoprotein tissue-type plasminogen activator (t-PA) is subject to hepatic clearance in humans. Here, the interaction of t-PA with a well-differentiated hepatoma cell line (HepG2) was examined. Suspended HepG2 cells bound 125I-t-PA in a specific, saturable, and reversible fashion through a Ca(2+)-dependent, active site-independent mechanism. Binding isotherms indicated a high affinity system with a single class of saturable binding sites (Kd 39 nM; maximum binding capacity 493,000 sites per cell). Bound t-PA was rapidly degraded at 37 degrees C in a manner inhibited by lysosomotropic agents or metabolic inhibitors. Pretreatment of t-PA with monoclonal antibodies against the EGF/fibronectin finger domain, but not kringle 2 or kringle 1, reduced total binding by 86%. Binding of 125I-t-PA to HepG2 cells was inhibited by monosaccharides fucose and galactose and by the neoglycoprotein fucosyl-albumin. Enzymatic removal of alpha-fucose residues, but not alpha-galactose, high mannose, or complex oligosaccharide from 125I-t-PA, reduced specific binding by 60 +/- 5%. Binding was also inhibited by high, but not low, molecular weight urokinase, which contains an EGF-based threonine-linked alpha-fucose homologous to that of t-PA. These data suggest that EGF-associated O-linked alpha-fucose may mediate t-PA binding and degradation by HepG2 cells. This mechanism may be relevant to other proteins with analogous structures.