tbuckley/cabot-search huggingface dataset:
Carcinoma of the Endometrium: Etiology, Diagnosis and Treatment
Authors: S. B. Gusberg
Journal: JAMA (1982)

This monograph, coauthored by a gynecologic oncologist and pathologist of distinction, is aimed at the practicing physician and serves its purpose well. It is concise, presented with clarity, and offers an overview of this tumor problem, including literature review, for the clinician who may require an update in his information about this common tumor. The expertise of the authors in the clinical aspects of this disease is evident and offers the clinician a modern view of diagnosis and treatment. In the case of the correlated oncologic sciences related to the tumor problem herein presented, the reader, of course, can only receive an introduction to these considerations in this short monograph, though the areas of special scientific expertise of these seasoned oncologists are evident. In other areas, the authors clearly express their own views of problems under current investigation and discussion. This is a useful volume that will enhance the literature
Magnesium-Induced Bradycardia
Authors: ARNOLD S. BERNS
Journal: Annals of Internal Medicine (1976)

Letters1 December 1976Magnesium-Induced BradycardiaARNOLD S. BERNS, M.D., KENNETH R. KOLLMEYER, PH.D.ARNOLD S. BERNS, M.D.Search for more papers by this author, KENNETH R. KOLLMEYER, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-6-760 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDepression of sinoatrial and atrioventricular conduction due to severe hypermagnesemia (serum magnesium concentration, 10 to 15 meq/litre) has been previously well documented (1-3). We recently had the opportunity to observe a patient with chronic renal insufficiency who showed severe junctional bradycardia associated with mild hypermagnesemia (serum magnesium concentration, 3.3 to 4.8 meq/litre). We wish to emphasize the association between mild elevations in serum magnesium concentration and clinical cardiotoxicity.A 62-year-old woman was admitted to Colorado General Hospital for the evaluation of hematemesis and melena. Past medical history included diabetes mellitus since age 50, lumbosacral osteoarthritis, hypertension, and peripheral vascular disease....References1. SMITHWINKLERHOFF PAH: Electrocardiographic changes and concentrations of magnesium in serum following intravenous injection of magnesium salts. Am J Physiol 126:720-730, 1939 CrossrefGoogle Scholar2. WACKERPARISI WA: Magnesium metabolism. N Engl J Med 278:712-717, 1968 CrossrefMedlineGoogle Scholar3. HURSTLOGUESCHLANT JBR (eds.): The Heart. 3rd ed. New York, McGraw-Hill, 1974, pp. 1500-1502 Google Scholar4. RANDALLCOHENSPRAY RMC: Hypermagnesemia in renal failure. Etiology and toxic manifestations. Ann Intern Med 61:73-88, 1964 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Division of Renal Diseases University of Colorado Medical Center 4200 East Ninth Avenue Denver, CO 80262 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySerum magnesium, mortality and disease progression in chronic kidney diseaseMagnesium for treating sickle cell diseaseMagnesium for treating sickle cell diseaseMagnesium for treating sickle cell diseaseMagnesium basicsSerum and erythrocyte magnesium in critically ill patientsMagnesium and cardiovascular diseaseMagnesium disorders and cardiovascular diseasesElectrocardiographic manifestations of combined hypercalcemia and hypermagnesemiaHypermagnesemia and perforated viscusAntacids for duodenal ulcer.Magnesium: Physiology, clinical disorders, and therapy 1 December 1976Volume 85, Issue 6Page: 760-761KeywordsAttentionBradycardiaDiabetes mellitusHypermagnesemiaHypertensionMagnesiumOsteoarthritisPeripheral vascular disease Issue Published: 1 December 1976 PDF DownloadLoading ...
What's within? Can the internal structure of perception be derived from regularities of the external world?
Authors: Rainer Mausfeld
Journal: Behavioral and Brain Sciences (2001)

Shepard's approach is regarded as an attempt to rescue, within an evolutionary perspective, an empiricist theory of mind. Contrary to this, I argue that the structure of perceptual representations is essentially co-determined by internal aspects and cannot be understood if we confine our attention to the physical side of perception, however appropriately we have chosen our vocabulary for describing the external world. Furthermore, I argue that Kubovy and Epstein's “more modest interpretation” of Shepard's ideas on motion perception is based on unjustified assumptions. [Kubovy &amp; Epstein; Shepard]
SURGICAL CONDITIONS CAUSED BY INTESTINAL PARASITES: REPORT OF TWO CASES
Authors: M. O. Robertson
Journal: JAMA (1924)

The agency of worms in the production of appendicitis has been discussed editorially inThe Journal.<sup>1</sup>Ravenel<sup>2</sup>has called attention to observations made by Desprès in 1868 and more recently by Metchnikoff. Hatori<sup>3</sup>reported finding<i>Ascaris lumbricoides</i>in the appendix in three appendicitis cases out of seventy-nine in which operation was performed. I saw two cases while in the Orient. Human feces are used for fertilizer in Korean gardens. The vegetables are eaten without cooking, and therefore a large percentage of the population is infested with parasites. <h3>REPORT OF CASES</h3><h3>Case 1.</h3> —A man, aged 20, came to the hospital, June 10, 1918, complaining of abdominal pain. About noon of the preceding day, when taken ill, he had called a Japanese physician, a graduate of the Japanese Government Medical School, who gave him a hypodermic injection which relieved him for the day, but he was still uncomfortable.
Reversible Acute Renal Failure from Combined Triamterene and Indomethacin
Authors: LAURENT FAVRE
Journal: Annals of Internal Medicine (1982)

As part of a study on the interaction between diuretics and renal prostaglandins, four healthy medical students receiving indomethacin for 8 days were also given triamterene for 3 days. Whereas renal function was initially normal in all four subjects, creatinine clearance decreased in two by 62% and 72% after concomitant administration of the two drugs, and was only restored to normal after 4 weeks. In control periods when triamterene or indomethacin was given alone renal function was preserved in all subjects. Urinary prostaglandin E2 was stimulated by triamterene and inhibited by indomethacin in all four subjects; both changes were more marked in the two sensitive subjects. Thus prostaglandin inhibition by indomethacin may unmask triamterene toxicity and contribute to the pathogenesis of the renal failure observed in sensitive subjects. As alternative therapy is readily available, avoidance of this potentially nephrotoxic association is recommended.
Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia
Authors: Sabrina Opatz, Harald Polzer, Tobias Herold, Nikola P. Konstandin, Bianka Ksienzyk, Evelyn Zellmeier, Sebastian Vosberg, Alexander Graf, Stefan Krebs, Helmut Blum, Karl-Peter Hopfner, Purvi M. Kakadia, Stephanie Schneider, Annika Dufour, Jan Braess, Maria Cristina Sauerland, Wolfgang E. Berdel, Thomas Büchner, Bernhard J. Woermann, Wolfgang Hiddemann, Karsten Spiekermann, Stefan K. Bohlander, Philipp A. Greif
Journal: Blood (2013)
Detecting structural changes in early experimental osteoarthritis of tibial cartilage by microscopic magnetic resonance imaging and polarised light microscopy
Authors: H A Alhadlaq
Journal: Annals of the Rheumatic Diseases (2004)

<b>Objectives:</b> To detect changes in the collagen fibril network in articular cartilage in a canine experimental model of early osteoarthritis (OA) using microscopic magnetic resonance imaging (μMRI) and polarised light microscopy (PLM). <b>Methods:</b> Eighteen specimens from three pairs of the medial tibia of an anterior cruciate ligament transection canine model were subjected to μMRI and PLM study 12 weeks after surgery. For each specimen, the following experiments were carried out: (<i>a</i>) two dimensional μMRI images of T<sub>2</sub> relaxation at four orientations; (<i>b</i>) the tangent Young’s modulus; and (<i>c</i>) two dimensional PLM images of optical retardance and fibril angle. Disease induced changes in tissue were examined across the depth of the cartilage at a μMRI resolution of 13.7–23.1 μm. <b>Results:</b> Several distinct changes from T<sub>2</sub> weighted images of cartilage in OA tibia were seen. For the specimens that were covered at least in part by the meniscus, the significant changes in μMRI included a clear shift in the depth of maximum T<sub>2</sub> (21–36%), a decrease in the superficial zone thickness (37–38%), and an increase in cartilage total thickness (15–27%). These μMRI changes varied topographically in the tibia surface because they were not significant in completely exposed locations in medial tibia. The μMRI results were confirmed by the PLM measurements and correlated well with the mechanical measurements. <b>Conclusion:</b> Both μMRI and PLM can detect quantitatively changes in collagen fibre architecture in early OA and resolve topographical variations in cartilage microstructure of canine tibia.
CD18/ICAM-1-dependent oxidative NF-kappaB activation leading to nitric oxide production in rat Kupffer cells cocultured with syngeneic hepatoma cells.
Authors: I Kurose, H Saito, S Miura, H Ebinuma, H Higuchi, N Watanabe, S Zeki, T Nakamura, M Takaishi, H Ishii
Journal: Journal of Clinical Investigation (1997)

Previous studies have indicated that nitric oxide (NO) released from Kupffer cells modulates biological viability of cocultured hepatoma cells. This study was designed to evaluate the mechanisms by which Kupffer cells synthesize and release NO in reponse to cocultured hepatoma cells. Kupffer cells isolated from male Wistar rats were cocultured with rat hepatoma cell line, AH70 cells. The sum of nitrite and nitrate levels increased in the culture medium of Kupffer cells with AH70 cells as compared with those of Kupffer cells or AH70 cells alone. Increased expressions of iNOS and iNOS mRNA in Kupffer cells cocultured with AH70 cells were detected by an immunofluorescence staining and a fluorescence in situ hybridization study, respectively. A fluorescence in situ DNA-protein binding assay revealed that NF-kappaB activation occurs in Kupffer cells and activated NF-kappaB moved into the nuclei preceding to an increased production of NO. Oxidative stress indicated by dichlorofluorescein fluorescence was observed in Kupffer cells cocultured with AH70 cells. An increased calcium mobilization indicated as increased fluo-3-associated fluorescence was also induced in Kupffer cells after coculture with AH70 cells. Monoclonal antibodies directed against rat CD18 and ICAM-1, as well as TMB-8, a calcium inhibitor, prevented the calcium mobilization, active oxygen production, and NF-kappaB activation in addition to the increased production of NO. Pyrrolidine dithiocarbamate, an inhibitor of oxidative NF-kappaB activation, diphenylene iodonium, an NADPH oxidase inhibitor, and quinacrine, a phospholipase A2 inhibitor, significantly attenuated the increase in dichlorofluorescein fluorescence, NF-kappaB activation, and NO production. Therefore, this study suggests that CD18/ICAM-1-dependent cell-to-cell interaction with hepatoma cells causes calcium mobilization and oxidative activation of NF-kappaB, which may lead to the increased production of NO in Kupffer cells.
Heart Transplantation, Problems and Progress
Authors: Paul S. Russell
Journal: New England Journal of Medicine (1969)

The early results of the first round of heart transplants are now being reported, and this issue of the Journal contains an account of 17 such transplants. The technical feasibility of the operation, originally described in animals, has now been demonstrated in the human being, in whom the urgency of clinical circumstances regarding both recipient and donor introduces complexities foreign to the experimental laboratory.The findings from the various heart-transplant clinics have all re-emphasized the fundamental importance of the rejection process as the central obstacle to reliable success with this organ as it is with others. The problems of donor-organ . . .
Human rights organisation condemns university's attempt to discredit one of its staff
Authors: N. Skaricic
Journal: BMJ (2009)

A Croatian court’s indictment of the attempt by a medical school to undermine the authority of one of its professors, after he spoke out about corruption in academia, was upheld last month by the Croatian office of the International Helsinki Federation for Human Rights.

The Administrative Court of the Republic of Croatia had ruled last October that the Zagreb School of Medicine’s decision to seek a psychiatric opinion of the work of the scientist Matko Marusic set a “dangerous precedent according to which anyone making critical statements about specific interest groups, communities, or individuals could be subjected to a review of their mental soundness.”

Last month’s decision by the Croatian office of the Helsinki federation to uphold the court’s ruling has been welcomed by the academics and scientists who have been campaigning for almost three years on behalf of Professor Marusic, founding coeditor of the Croatian Medical Journal .

Iain Chalmers, editor of the James Lind Library, welcomed the office’s decision and said: “Nada Cikes [dean of the Zagreb School of Medicine] and other officials at the medical school . . . have behaved outrageously to both editors in chief of the Croatian Medical Journal .

“Their character assassinations appear to have been attempts …
Direct Anastomosis of the Bilateral Internal Mammary Artery to the Distal Coronary Artery, Without a Magnifier, for Severe Diffuse Coronary Atherosclerosis
Authors: AKIO SUZUKI, EARLE B. KAY, JAMES D. HARDY
Journal: Circulation (1973)

Forty-three cases of direct anastomosis of unilateral or bilateral internal mammary artery (IMA) and distal coronary artery (DCA), with or without saphenous vein graft (SVG), for severe, diffuse, ischemic coronary artery disease are reported. The technique of anastomosis of IMA and DCA without a magnifier or microscope is discussed in detail. The operative mortality was less than 5% (2 of 43 patients). The initial patency rate of IMA and DCA anastomosis was 97% (34 of 35). Only 8 patients have been restudied 4 to 16 months after surgery. Flow through the IMA ranged from 30 to 60 cc/min, averaging 45 cc/min at the time of surgery. Postoperative ventricular function studies suggest an increase of left ventricular emptying and endocardial fiber-short-ening rate in those with well-functioning grafts. The significant advantage of this technique is that it extends the indications for direct coronary artery reconstruction by anastomosing bilateral IMA to DCA near the apex, where the size of the artery is 1 to 1.5 mm and the SVG is more likely to occlude because of the size discrepancy and expected relatively low blood flow.
Corrective and Reconstructive Rhinoplasty
Authors: Bradford Cannon
Journal: JAMA (1968)

The readers ofThe Journalwho are on the mailing list of Springer-Verlag of Berlin and New York are familiar with their current publications and the beautiful multicolored illustrations reprinted from the texts. Denecke and Meyer's monograph on rhinoplasty, which is volume 1 of two volumes on<i>Plastic Surgery of the Head and Neck</i>, is filled with similar accurate and vivid illustrations. The translator, Lowell Oxtoby, has been most successful in his basic premise to write in "American" English so that descriptions are very clear and readable. This volume is an encyclopedia of rhinoplasty. The authors make the point that they have included the tested methods of many surgeons, whereas most writers on the subject describe only their own procedures. A perusal of the bibliography will convince the reader that few, if any, of the writings in the world literature have been over-looked. For example, in 1898 the island flap
Babies Are Coming&lt;subtitle&gt;Don't Cap Medicaid&lt;/subtitle&gt;
Authors: Katherine Swartz
Journal: JAMA (1997)

Congress and the White House are beginning new budget negotiations with a strong push to cap federal Medicaid expenditures. Simultaneously, there is bipartisan consensus that providing health care for children, especially young children, is a high national priority. The 2 objectives are in conflict. The rhetoric on limiting Medicaid expenditures ignores both the role Medicaid has today in paying for births and the greater need for this program in the future. In 1994, there were 12 states in which Medicaid paid for 45% or more of all births.<sup>1</sup>Nationally in that year, Medicaid paid for 39% of all births. The 39% figure is up from 32% in 1991, a time when the late 1980s' Medicaid eligibility expansions for pregnant women had become largely implemented.<sup>2</sup> For the past 5 years, the rising percentage of Medicaid births reflects a stable number of Medicaid births and a declining number of births
Shortage of sperm donors predicted when anonymity goes
Authors: C. Dyer
Journal: BMJ (2004)

Fertility specialists are warning that the already short supply of donor eggs and sperm in the United Kingdom could drop further after last week's announcement that donors are to lose their right to anonymity in 2005.

The Department of Health announced that children conceived as a result of donated sperm, eggs, and embryos will in future be able to access information …
1028-168 Is asymmetric dimethylarginine a marker for diabetes, coronary artery disease, and death/myocardial infarction? Results of the Intermountain heart collaborative angiographic registry study
Authors: Jeffrey L Anderson, John F Carlquist, William L Roberts, Benjamin D Horne, Tami L Bair, Elisabeth L Schwarz, Marzia Pasquali, Joseph B Muhlestein
Journal: Journal of the American College of Cardiology (2004)
A Book Tumor
Authors: Mark L. Dembert
Journal: JAMA (1986)

I suffer from what my wife calls a book tumor, a steadily growing personal library amassed over the past 15 years. She often asks me why I can't just get rid of many of the books I have read. I tell her I am afraid that if I sell them or give them away, the new owners might not appreciate the book or the trouble I went to to find it. I emphasize the timeless quality of books. My feelings about my library are strong and my need to keep it is heartfelt. Giving up a well-appreciated book is like giving up a friend, and that is just not an easy thing for me to do. These feelings began during my medical school days in center-city Philadelphia in the early 1970s. I became a steady and eager customer of Middle Earth Books, a small but busy store sandwiched between apartment
Prolongation of atrioventricular conduction time by electrical stimulation of the carotid sinus nerves in man.
Authors: C Borst, J M Karemaker, A J Dunning
Journal: Circulation (1982)

Electrical stimulation of the carotid sinus nerves was applied during diagnostic catheterization of two patients who had coronary artery disease. The immediate reflex prolongation of the atrioventricular (AV) interval was due to prolongation of the AH interval only and was roughly parallel to the reflex RR interval prolongation evoked without atrial pacing. After cholinergic block, the reduced prolongation of both the RR interval and the AV interval caused by reflex inhibition of sympathetic tone followed a time course similar to the arterial pressure decrease. This is the first demonstration in man of the parallel baroreflex effects on the sinoatrial node and the AV node.
Mincle is a long sought receptor for mycobacterial cord factor
Authors: Isamu Matsunaga, D. Branch Moody
Journal: The Journal of Experimental Medicine (2009)

Mycobacterium tuberculosis is a leading killer worldwide, yet the adjuvancy of its cell wall has proven to be a valuable therapeutic tool for vaccination and immunotherapy. Much research effort has focused on the mycobacterial glycolipid trehalose-6,6'-dimycolate (TDM), a potent immunostimulant that is also known as cord factor. Now, the identification of the monocyte-inducible C-type lectin (Mincle) as an essential receptor for TDM provides new insight into the formation of the characteristic granulomas in tuberculosis and an avenue for rational adjuvant design.
Attracting, retaining and nurturing young academic clinicians
Authors: John Cotes
Journal: Journal of the Royal Society of Medicine (2011)

Jeffrey Aronson has described the habitat in which a prospective clinical research worker might be expected to flourish.1 The features of such a person need similar consideration. But the experience of those who have been successful in the past may not be a reliable guide because circumstances are changing. Enduring requirements probably include an independent, even slightly rebellious outlook, an ongoing interest in science, integrity and a preoccupation with the topic under consideration that leads to it being near the top of the researcher's mind several times each day. In our household such thoughts are banned from consideration over the morning cup of tea. In addition, while a clinical research worker needs a concern for and empathy with people, in my view this should not lead to job satisfaction being linked to clinical responsibility. The personal commitment to achieve a good clinical result can be in conflict with that needed for research, so in a joint appointment the research component is often the less productive partner.

In my own experience, features that were helpful included early interest, inspirational pre-clinical teaching, liberating advice to make a career that differed from those of my peers and an early decision to ‘have a go’. This led to a logical sequence of jobs (including choice of a clinical school) based on pursuit of an ideal. Several of the resulting decisions surprised my colleagues, but due to chance, luck and a supportive environment I survived and even flourished. However, my professional career did not include the groundbreaking discovery we all aspire to. I like to think this came 15 years into my ‘retirement’, though now, seven years later only a few people think I am correct. If the concept endures, it will be used for the benefit of patients. Thus, research is a process; it has a variable timescale and the outcome cannot always be predicted.