tbuckley/cabot-search huggingface dataset:
488 Virodynamic predictors of treatment response to peginterferon and lamivudine combination treatment of HBeA-positive chronic hepatitis B
Authors: H.L.Y. Chan, U. Mihm, S. Zeuzem, A.M.L. Chim, A.Y Hui, V.W.S. Wong, J.J.Y. Sung, E. Herrmann
Journal: Journal of Hepatology (2006)
Vampires, Burial, and Death: Folklore and Reality
Authors: R. Ted Steinbock
Journal: JAMA (1989)

The folklore of the dead returning to life is a worldwide phenomenon. Concentrating on the vampire and revenant legends of eastern Europe, Paul Barber carefully analyzes the few documented cases spanning centuries. The exhumations of suspected vampires include descriptions of blood on the lips of the dead body, replacement of old skin with new pink skin, a swollen abdomen containing liquefied blood, supple joints, and how the corpse cried out when a stake was driven into its heart. The dead people most commonly accused of being vampires are those dying suddenly or violently and often unobserved—such as by murder, suicide, or drowning. The first person dying at the onset of a sudden epidemic or plague may also be incriminated. Utilizing modern forensic pathology, Barber argues that the lore of vampire/revenant is an elaborate folk-hypothesis to explain quite natural phenomena of decomposition. Moreover, he notes a universal cultural division between the
Symptomatic Exacerbation of Crohn Disease after Treatment with High-Dose Interleukin-2
Authors: Joseph A. Sparano
Journal: Annals of Internal Medicine (1993)

Two patients treated with high-dose interleukin-2 (IL-2), who had a history of Crohn disease that was clinically quiescent for 4 and 9 years before therapy, developed symptomatic reactivation of Crohn disease requiring surgical intervention. At laparotomy, both patients had histologic evidence of active Crohn disease. One patient had previously received another cytokine, -interferon-, without disease reactivation, suggesting that this effect was specific for IL-2. The striking temporal relation between the administration of IL-2 and the symptomatic reactivation of previously quiescent Crohn disease suggests the need to carefully evaluate patients with a history of inflammatory bowel disease who are considered for IL-2 therapy and provides evidence supporting an important role for IL-2 in the pathogenesis of Crohn disease.
Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis
Authors: Tetsuya Ueda, Stefano Volinia, Hiroshi Okumura, Masayoshi Shimizu, Cristian Taccioli, Simona Rossi, Hansjuerg Alder, Chang-gong Liu, Naohide Oue, Wataru Yasui, Kazuhiro Yoshida, Hiroki Sasaki, Sachiyo Nomura, Yasuyuki Seto, Michio Kaminishi, George A Calin, Carlo M Croce
Journal: The Lancet Oncology (2009)
Surgical Treatment of Regional Enteritis
Authors: Bentley P. Colcock, John H. Vansant
Journal: New England Journal of Medicine (1960)

REGIONAL enteritis is a disease that primarily affects the small intestine but may involve any region of the gastrointestinal tract from the stomach to the sigmoid colon. Management of this condition continues to be controversial. However, in the chronic complicated phases, surgery not only offers the most satisfactory results but may be imperative.Between 1933 and June, 1958, 376 patients with regional enteritis were treated at the Lahey Clinic; 304 (80.8 per cent) were treated by surgical technics. This study concerns itself primarily with the 304 patients who were treated surgically. Two hundred and seventy-seven patients were treated by radical . . .
Cost–effectiveness of repeated aphereses in poor mobilizers undergoing high-dose chemotherapy and autologous hematopoietic cell transplantation
Authors: C Chabannon, A-G Le Corroller, F Viret, C Eillen, C Faucher, J-P Moatti, P Viens, N Vey, A-C Braud, G Novakovitch, P Ladaique, A-M Stoppa, J Camerlo, D Genre, D Maraninchi, D Blaise
Journal: Leukemia (2003)
Physiologic formation of intracellular vesicles in mature erythrocytes
Authors: Richard H. Sills, Judith H. Tamburlin, Nilka J. Barrios, Philip L. Yeagle, Chester A. Glomski
Journal: American Journal of Hematology (1988)

Abstract The ability of mature erythrocytes to spontaneously form intracellular vesicles has been implied from clinical studies but has not been examined experimentally. An in vitro model was developed to demonstrate whether mature erythrocytes are capable of spontaneously forming intracellular vesicles. Normal human erythrocytes were incubated in vitro at 37°C for 144 hr in a synthetic medium. During the course of these incubations, approximately 4% of erythrocytes developed intracellular vesicles which were quantitated by using interference contrast microscopy. Electron microscopic studies confirmed the intracellular nature of these vesicles. Incubation of erythrocytes in autologous plasma produced similar results. The rate of vesicle acqulsition in vivo was measured by quantitating erythrocyte vesicles immediately prior to and following splenectomy. The rates of vesicle acquisition in vivo and in vitro were comparable. This in vitro model confirms the ability of mature erythrocytes to spontaneously form intracellular vesicles and strongly supports the concept that this is a physiologic process.
Defence Society Subscriptions
Authors: P. H. Addison
Journal: BMJ (1972)

sharply.Indeed there was one fewer in 1963 than in 1953, though there had been some increase in 1961 and 1962.The 10 years' operative mortality was 0-87 % and the morbidity due to chest infection, wound infection, and deep venous thrombosis was 9-8%.I can confirm the finding of a high proportion of stones at operation (97 4% in 1960), whereas only 29% had been demonstrated radiologically preoperatively in tiat year.The most striking feature of 1960 was that there were no operative cholangiograms carried out.Indeed, 1961 was the first year they were done at Frenchay, though only 11 were done in the subsequent three years.This led to 37-6% of all common bile ducts being explored, half of these unnecessarily.As operative cholangiography is now routine during all cholecystectomies at that hospital it would be interesting to compare the 1960 and 1970 total figures with special reference to the problem of recurrent common-bile-duct stones.-Iam, etc.,
Poliomyelitis in Pregnancy
Authors: Mila E. Rindge
Journal: New England Journal of Medicine (1957)

SINCE the first report by Aycock,1 in 1941, of an increased incidence of poliomyelitis in pregnancy, numerous articles on this subject have been presented. Previously, poliomyelitis as a complication of pregnancy was apparently rare. Aycock reported only 28 cases from a review of the literature and added 28 from his own experience. He estimated the expectancy of paralytic poliomyelitis as less than 1 out of 1000 cases of poliomyelitis and less than 1 out of 50,000 pregnancies. Gifford and Hullinghorst,2 in 1948, presented a review of 169 cases from the literature and 1 from their own experience. In 1953 Bowers . . .
A randomized controlled study of peanut oral immunotherapy: Clinical desensitization and modulation of the allergic response
Authors: Pooja Varshney, Stacie M. Jones, Amy M. Scurlock, Tamara T. Perry, Alex Kemper, Pamela Steele, Anne Hiegel, Janet Kamilaris, Suzanne Carlisle, Xiaohong Yue, Mike Kulis, Laurent Pons, Brian Vickery, A. Wesley Burks
Journal: Journal of Allergy and Clinical Immunology (2011)
Regular pace training increases endothelium-dependent vasodilatation in untrained women
Authors: D Reihmane, P Tretjakovs, A Jurka
Journal: British Journal of Sports Medicine (2010)

Almost all scientific research that investigates how exercise training affects the circulatory system estimates main arteries, like brachial artery and few focus on the cutaneous microvascular function. The aim of this study was to estimate the impact of 25 Programmed Aerobic/Anaerobic/Accommodating Circuit Exercise (PACE) training sessions on changes in vasomotor reactions (microvascular beds of the skin) in healthy untrained women. PACE training is a short duration (∼30 min), intense physical activity that includes both aerobic and anaerobic states, that changes after every 30 s. 20 women participated in this study (age 35±10 years; body mass index 26.7±4.2). The laser Doppler flow technique (MoorLDI2) was used to estimate the regional blood flow changes on the upper part of the palm induced by local acetylcholine (1% Ach) and sodium nitroprusside (1% SNP) iontophoresis; assessment of concentrations of C reactive protein and cortisol were made with the Immulite 2500. There was an increase in endothelium-dependent vasodilatation after 25 PACE training sessions, that was estimated by laser dopplerography test with 1% Ach iontophoresis (292±80 PU vs 335±88 PU, p&lt;0.01). 25 PACE training sessions did not cause any significant changes in endothelium-independent vasodilatation (1% SNP iontophoresis). There was a negative correlation between 1% Ach-induced vasodilatation and C reactive protein (p&lt;0.05; r=−0.38), but there was a positive correlation between 1% SNP-induced vasodilatation and cortisol (p&lt;0.01; r=0.53), when data from pre and post 25 PACE training sessions are taken together (n=40). In conclusion, 25 PACE training sessions improve endothelium-dependent vasodilatation, but have no effect on endothelium-independent vasodilatation. Inflammatory processes (higher C reactive protein level) reduce the capacity of endothelium-dependent vasodilatation.
Odds ratios should be avoided when events are common
Authors: D. G Altman, J. J Deeks, D. L Sackett
Journal: BMJ (1998)

EDITOR—A news item stated that “a review article written by authors with affiliations to the tobacco industry is 88 times more likely to conclude that passive smoking is not harmful than if the review was written by authors with no connection to the tobacco industry.”1 We are concerned that readers may have interpreted this huge effect at face value. The proportions …
Persistent Expression of Cytokine in the Chronic Stage of Viral Myocarditis in Mice
Authors: Tetsuo Shioi, Akira Matsumori, Shigetake Sasayama
Journal: Circulation (1996)

Dilated cardiomyopathy (DCM) is one of the most frequent causes of heart failure of unknown origin. One possible cause of DCM is considered to be a sequel to myocarditis. However, the mechanism of progression from viral myocarditis to DCM is still not clear.The expression of the immunoregulatory cytokines interferon (IFN)-gamma and interleukin (IL)-2 and the proinflammatory cytokines IL-1 beta and tumor necrosis factor (TNF)-alpha in the heart tissue was studied in a murine model of postmyocarditis DCM induced by encephalomyocarditis virus. IFN-gamma, IL-1 beta, and TNF-alpha mRNA increased 3 days after virus inoculation. IL-2 mRNA was detectable 7 days after inoculation. The peak expression of all cytokine genes examined was seen 7 days after inoculation. The expression of these cytokine genes decreased thereafter but persisted 80 days after inoculation. IL-1 beta gene expression in the chronic stage was relatively high compared with other cytokines and was correlated with the ratio of heart weight to body weight and the extent of fibrotic lesions. Immunohistochemical analysis revealed that some of the mononuclear cells, endothelial cells, and interstitial macrophages were positive for IL-1 beta or TNF-alpha and fibroblasts were positive for IL-1 beta in the heart tissue of mice 80 days after inoculation.Persistent expression of cytokines was seen in a murine model of postmyocarditis DCM. These cytokines may have important implications in the pathogenesis of DCM.
VENEREAL PROPHYLAXIS THAT IS FEASIBLE.
Authors: LUDWIG WEISS
Journal: JAMA (1903)

In attempting to speak on the prophylaxis of venereal diseases before so highly a representative body, the reader is conscious of the fact that he has only very little to offer that is new and that has not already engaged the minds of his peers assembled here. The topic is of vast importance to "the well-being of the people, whose working and earning capacity is encroached on, not so much by the active accidents caused by those diseases, but much more through their chronic manifestations, especially in women. My object is that the profession as a whole should take cognizance of this ever-present scourge and its dangers to society, through the medium of the American Medical Association, and that a propaganda of action should be instituted by the members in their different states to devise measures for diminishing the spread of and for reducing the morbidity and
Activating Mutations in the Gene Encoding the ATP-Sensitive Potassium-Channel Subunit Kir6.2 and Permanent Neonatal Diabetes
Authors: Anna L. Gloyn, Ewan R. Pearson, Jennifer F. Antcliff, Peter Proks, G. Jan Bruining, Annabelle S. Slingerland, Neville Howard, Shubha Srinivasan, José M.C.L. Silva, Janne Molnes, Emma L. Edghill, Timothy M. Frayling, I. Karen Temple, Deborah Mackay, Julian P.H. Shield, Zdenek Sumnik, Adrian van Rhijn, Jerry K.H. Wales, Penelope Clark, Shaun Gorman, Javier Aisenberg, Sian Ellard, Pål R. Njølstad, Frances M. Ashcroft, Andrew T. Hattersley
Journal: New England Journal of Medicine (2004)

Patients with permanent neonatal diabetes usually present within the first three months of life and require insulin treatment. In most, the cause is unknown. Because ATP-sensitive potassium (K(ATP)) channels mediate glucose-stimulated insulin secretion from the pancreatic beta cells, we hypothesized that activating mutations in the gene encoding the Kir6.2 subunit of this channel (KCNJ11) cause neonatal diabetes.We sequenced the KCNJ11 gene in 29 patients with permanent neonatal diabetes. The insulin secretory response to intravenous glucagon, glucose, and the sulfonylurea tolbutamide was assessed in patients who had mutations in the gene.Six novel, heterozygous missense mutations were identified in 10 of the 29 patients. In two patients the diabetes was familial, and in eight it arose from a spontaneous mutation. Their neonatal diabetes was characterized by ketoacidosis or marked hyperglycemia and was treated with insulin. Patients did not secrete insulin in response to glucose or glucagon but did secrete insulin in response to tolbutamide. Four of the patients also had severe developmental delay and muscle weakness; three of them also had epilepsy and mild dysmorphic features. When the most common mutation in Kir6.2 was coexpressed with sulfonylurea receptor 1 in Xenopus laevis oocytes, the ability of ATP to block mutant K(ATP) channels was greatly reduced.Heterozygous activating mutations in the gene encoding Kir6.2 cause permanent neonatal diabetes and may also be associated with developmental delay, muscle weakness, and epilepsy. Identification of the genetic cause of permanent neonatal diabetes may facilitate the treatment of this disease with sulfonylureas.
Hospital admission leads to drug errors
Authors: Susan Mayor
Journal: BMJ (2005)

In over half of hospital admissions of elderly people in Canada, drug errors occur at the time of admission, including some potentially harmful changes in drugs or dosages, warned a recent study ( Archives of Internal Medicine 2005;165: 424-9). Researchers from the University of Toronto screened the medical charts of all patients admitted on an unplanned basis to the general internal medical clinics …
China aims to improve health of newborn by law
Authors: R Tomlinson
Journal: BMJ (1994)

Effective June 1, 1995, China will have a new law covering aspects of maternal and infant health care. The controversial law provides for improvements in perinatal health care, but it also mandates a premarital physical examination for couples to determine if either person has a genetic or infectious disease or a mental disorder which would have an adverse effect on marriage and childbearing. Marriage must be postponed if any of the defined infectious diseases (including AIDS, gonorrhea, syphilis, and leprosy) or a mental disorder is detected. In cases of genetic diseases, the couple must agree to adopt longterm contraceptive measures or to become sterilized. When a serious genetic defect is uncovered during a pregnancy, physicians are to advise abortion. Whereas the law stipulates that consent must be obtained before an abortion or sterilization is performed, there is concern that the law will lead to forced sterilization. Also, medical experts are still trying to devise a list of "serious genetic disorders" in a social climate which has little tolerance for any type of disability. The new law forbids the use of prenatal testing to determine the sex of a fetus unless there are medical indications for such a determination. In some areas of China, selective abortion of female fetuses has resulted in a birth ratio of 131 boys to 100 girls.
Can a Brief Antepartum Preventive Group Intervention Help Reduce Postpartum Depressive Symptomatology?
Authors: Zoltan Kozinszky, Robert B. Dudas, Iván Devosa, Sarolta Csatordai, Éva Tóth, Dávid Szabó, János Sikovanyecz, Katalin Barabás, Attila Pál
Journal: Psychotherapy and Psychosomatics (2012)

&lt;i&gt;Background:&lt;/i&gt; Psychosocial and psychological interventions are generally effective in reducing depressive symptomatology in the postpartum period. Our aim was to evaluate the effectiveness of a brief preventive group intervention for postpartum depression (PPD) in a naturalistic setting, and study the effect of this on social and psychological risk factors. &lt;i&gt;Methods:&lt;/i&gt; We conducted a randomized controlled trial (n = 1,719) in south-eastern Hungary in 62 antepartum centers. Pregnant women (n = 710) underwent a 4-session preventive group intervention whereas a control group (n = 1,009) attended 4 sessions providing the same information given in usual care. &lt;i&gt;Results:&lt;/i&gt; Our intervention appeared to significantly reduce the risk of PPD, as defined by Leverton Questionnaire total scores (OR = 0.69). It resulted in an absolute risk reduction of about 18% in those with antepartum depression and 0.5% in those with no depression at recruitment. A multiple logistic regression analysis revealed a much reduced risk in those with a perceived lack of partner support (OR = 0.4) in the treatment group. Unplanned pregnancy, an irreversible risk factor affecting every fifth woman, also seemed to have a reduced effect on PPD after our group intervention (OR = 0.81). &lt;i&gt;Conclusions:&lt;/i&gt; A brief preventive antepartum group intervention focusing on psychoeducation, stress management, improving coping mechanisms, and the development of social support can be effective in reducing postpartum depressive symptomatology.
Possibly Immunosuppresive Factors in Blood Products
Authors: RICHARD J. ABLIN
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 January 1984Possibly Immunosuppresive Factors in Blood ProductsRICHARD J. ABLIN, PH.D., MAURICE J. GONDER, M.D.RICHARD J. ABLIN, PH.D.Search for more papers by this author, MAURICE J. GONDER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-1-155_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recent reports of the development of the acquired immunodeficiency syndrome in hemophiliacs receiving factor VIII and other clotting concentrates have prompted immunologic studies of these patients, such as the one reported by deShazo and colleagues (1). The emergence of the syndrome in hemophiliacs has also prompted us to report some of our observations (2) of the immunosuppressive properties of seminal plasma that might help explain their underlying immunosuppression.The immunosuppressive factor(s) in seminal plasma is possibly linked to transglutaminase activity. Transglutaminases, as they occur in the blood plasma, are more familiarly known as factors XIII and XIIIa...References1. DESHAZO R, ANDES W, NORDBERG J, NEWTON J, DAUL C, and BOZELKA B. An immunologic evaluation of hemophiliac patients and their wives: relationships to the acquired immunodeficiency syndrome. Ann Intern Med. 1983;99:159-64. LinkGoogle Scholar2. ABLIN R, BHATTI R, BUSH I, and GUINAN P. Immunosuppression of cell- and serum-mediated tumour-associated immunity in prostatic cancer by human seminal plasma. Eur J Cancer. 1980;16:775-80. CrossrefMedlineGoogle Scholar3. ELLIOTT J, HOPPES W, PLATT M, THOMAS J, PATEL I, and GANSAR A. The acquired immunodeficiency syndrome and Mycobacterium avium-intracellulare bacteremia in a patient with hemophilia. Ann Intern Med. 1983;98:290-3. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD J. ABLIN, PH.D.; MAURICE J. GONDER, M.D.Affiliations: State University of New York at Stony Brook School of Medicine Stony Brook, NY 11794 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBlood Product Immunosuppression and the Acquired Immunodeficiency SyndromeRICHARD J. ABLIN, Ph.D., JOHN M. BARTKUS, B.S., MAURICE J. GONDER, M.D.Immunosuppression by seminal plasma and its possible clinical significance 1 January 1984Volume 100, Issue 1Page: 155-156KeywordsAIDSBlood coagulationBlood plasmaImmunosuppressivesSemen ePublished: 1 December 2008 Issue Published: 1 January 1984 PDF downloadLoading ...
The Role of Indoor Allergen Sensitization and Exposure in Causing Morbidity in Women with Asthma
Authors: Sarah A. Lewis, Scott T. Weiss, Thomas A. E. Platts-Mills, Harriet Burge, Diane R. Gold
Journal: American Journal of Respiratory and Critical Care Medicine (2002)

Longitudinal evidence that indoor allergen exposure causes morbidity in sensitized individuals with asthma is scarce. We evaluated the association of allergen sensitization and home exposure to short- and long-term morbidity in 140 women with asthma and to asthma prevalence in 458 women from metropolitan Boston. Cockroach (Blattella germanica), dust mite (Dermatophagoides farinae), and cat (Felis domesticus) allergens in home dust samples, and specific immunoglobulin E antibodies were measured at outset, and doctor-diagnosed asthma and markers of asthma morbidity were ascertained by questionnaire during a 4-year follow-up. Cat- and cockroach-sensitive (immunoglobulin E immunocap [Cap] class > or = 1) women with asthma reported greater morbidity in the past year at the start, and during follow-up, if high levels of the relevant allergen were found. Women with asthma sensitized to cat allergen and with concentrations at 8 microg/g or greater were more likely to have used steroid (adjusted odds ratio [95% confidence interval] 2.7 [1.2-6.2]) and wheezed without a cold (odds ratio 6.8 [3.3- 14.0]) during follow-up. Those sensitized and exposed to cockroach (Bla g 1 or 2 > or = 2 U/g) were at least three times more likely to have used steroid and to have attended a hospital emergency room; the size of the effect upon steroid use was maintained, but the precision was reduced and the 95% confidence interval included one (p = 0.07), with adjustment for race and poverty. We conclude that cockroach and cat allergens may contribute to asthma morbidity in sensitized women.