tbuckley/cabot-search huggingface dataset:
In Loring Park
Authors: Frederic L. Coe
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Estrogen Effects on Phenothiazine Derivative Blood Levels
Authors: M. Khaled El-Yousef
Journal: JAMA (1974)

To the Editor.—  A patient having morning sickness developed a dystonic reaction with a single dose of prochlorperazine (Compazine). Estrogens are reportedly increased during that time of pregnancy, and their possible influence on such a reaction was entertained. Utilizing a dependable and sensitive fluorometric method for the assay of plasma butaperazine, 1 the effects of conjugated estrogens on plasma levels of this phenothiazine derivative were studied. Four postmenopausal female schizophrenic patients, having normal blood chemistry (automated multiple analysis system), thyroid, and liver function tests, and following a week on no medication, were randomly assigned to either a seven-day control period of receiving no hormone, or an experimental period of receiving conjugated estrogens (Premarin), 1.25 mg daily, with a crossover design that used subjects as their own controls. On the seventh day of each period, a single oral dose of 40 mg of butaperazine was given to subjects who had fasted
Pulmonary and intracerebral plasmacytomas in a patient without multiple myeloma: A case report
Authors: Brandon Hayes‐Lattin, Charles D. Blanke, Thomas G. Deloughery
Journal: American Journal of Hematology (2003)

Abstract Extramedullary plasmacytoma of the lung or brain parenchyma is rare. We report herein a case of extramedullary plasmacytoma involving both the lung and parenchymal brain. We review the literature, comparing and contrasting the current case. Am. J. Hematol. 73:131–134, 2003. © 2003 Wiley‐Liss, Inc.
Large haematoxylin-stainable keratohyaline granules in solar keratoses: immunohistochemical comparison using anti-Ted-H-1 antibody and antiloricrin antibody
Authors: M. Takahashi, Y. Horiuchi, T. Tezuka
Journal: British Journal of Dermatology (2005)

Our previous study showed that large keratohyaline granules (KHG) in molluscum contagiosum that stained with haematoxylin also reacted with anti-Ted-H-1 monoclonal antibody (mAb), but not with antifilaggrin mAb or antiloricrin polyclonal antibody (pAb). This finding indicated that the Ted-H-1 antigenic protein is a haematoxylin-stainable protein in KHG.To clarify the identity of the major component protein of the large KHG in solar keratosis, another disorder in which large KHG are observed.An enzyme immunohistochemical study was performed using antifilaggrin mAb, anti-Ted-H-1 mAb and antiloricrin pAb. Immunofluorescent double staining and immunoelectron microscopic analyses were performed using anti-Ted-H-1 mAb and antiloricrin pAb.Antifilaggrin mAb, anti-Ted-H-1 mAb and antiloricrin pAb reacted with normal KHG in nonlesional skin of solar keratosis, while only anti-Ted-H-1 mAb reacted with the large KHG in the lesions of solar keratosis. Antifilaggrin mAb did not react with large KHG. Antiloricrin pAb reacted with the cell membrane of the stratum granulosum, but not with large KHG.These findings suggest that the haematoxylin-stainable protein in the large KHG would be a Ted-H-1 antigen protein which was neither filaggrin nor loricrin.
Borderline Pulmonary Arterial Pressure Is Associated with Decreased Exercise Capacity in Scleroderma
Authors: Gabor Kovacs, Robert Maier, Elisabeth Aberer, Marianne Brodmann, Stefan Scheidl, Natascha Tröster, Christian Hesse, Wolfgang Salmhofer, Winfried Graninger, Ekkehard Gruenig, Lewis J. Rubin, Horst Olschewski
Journal: American Journal of Respiratory and Critical Care Medicine (2009)

Pulmonary arterial hypertension is associated with impaired exercise capacity and decreased survival in patients with scleroderma. Randomized controlled studies showed significant benefit of targeted therapies in patients with a resting mean pulmonary arterial pressure (MPAP) greater than 25 mm Hg. The clinical relevance of pulmonary arterial pressure values in the upper normal range is unknown.To examine the clinical relevance of pulmonary arterial pressure in scleroderma patients.After a noninvasive screening program, 29 patients with systemic sclerosis without significant lung fibrosis and without known pulmonary arterial hypertension underwent right heart catheterization and simultaneous cardiopulmonary exercise test. A six-minute walk distance (6MWD) was determined within 48 hours.A resting MPAP above the median (17 mm Hg) was associated with decreased 6MWD (396 +/- 71 vs. 488 +/- 76 m; P < 0.005) and peak Vo(2) (76 +/- 11% vs. 90 +/- 24%; P = 0.05). Resting pulmonary vascular resistance was inversely correlated with 6MWD (r = 0.45; P < 0.05). At 25 and 50W, MPAP above the median (23 and 28 mm Hg) was associated with decreased 6MWD (P < 0.005; P < 0.0005). At peak exercise, MPAP showed no association with 6MWD or peak Vo(2); however, cardiac index was positively (r = 0.45; P < 0.05) and pulmonary vascular resistance was negatively correlated with 6MWD (r = -0.38; P < 0.05).MPAP and resistance in the upper normal range at rest and moderate exercise are associated with decreased exercise capacity and may indicate early pulmonary vasculopathy in patients with systemic sclerosis. Investigations on the prognostic and therapeutic implications of such borderline findings are warranted. Clinical trial registered with http://www.clinicaltrials.gov (NCT00609349).
Palliative Procedure for Treatment of Transposition of the Great Vessels
Authors: GEORGE G. LINDESMITH, BERT W. MEYER, JOHN C. JONES, MARIAN GALLAHER
Journal: Circulation (1965)

1. Extreme efforts at palliation seem indicated in the very young infant with transposition of the great vessels and no accompanying defects of note since good candidates for later total correction may thereby be preserved. [see table in the PDF file] 2. A palliative procedure is presented wherein an atrial septal defect is created, and the blood flow from the inferior vena cava is diverted through the defect. 3. Presented are nine patients less than two months of age and with arterial oxygen saturations less than 35% who underwent the described procedure. 4. There were two early and two late deaths. The survivors are all doing well clinically and have required no further procedure.
Roadside drug testing would not be much of a deterrent
Authors: A. R. Winstock
Journal: BMJ (2012)

As part of a wider survey on drug use patterns and harms conducted at the end of 2011 by Global Drug Survey (www.globaldrugsurvey.com), in partnership with Mixmag and the Guardian newspaper, we asked current cannabis smokers about the risk of being identified as intoxicated with cannabis (without alcohol) while …
Presence of activated IgE, eosinophils and T-cells in duodenal biopsies from adults with birch pollen allergy
Authors: Jenny M Magnusson, Xiao Ping Lin, Anna Dahlman Höglund, Lars Åke Hanson, Olle Magnusson, Esbjörn Telemo, Ulf Bengtsson, Staffan Ahlstedt
Journal: Journal of Allergy and Clinical Immunology (2002)
Levels of TGF-α and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival
Authors: Jennifer Rubin Grandis, Mona F. Melhem, William E. Gooding, Roger Day, Valerie A. Holst, Marilyn M. Wagener, Stephanie D. Drenning, David J. Tweardy
Journal: JNCI Journal of the National Cancer Institute (1998)

The most accurate predictor of disease recurrence in patients treated for head and neck squamous cell carcinoma is, at present, the extent of regional lymph node metastasis. Since elevated levels of epidermal growth factor receptor (EGFR) and of its ligand, transforming growth factor-alpha (TGF-alpha), have been detected in primary tumors of patients with head and neck squamous cell carcinoma, we determined whether tumor levels of these proteins were of prognostic importance.Monoclonal antibodies specific for EGFR and TGF-alpha were used for immunohistochemical detection of each protein in tissue sections of primary tumors from 91 patients who were treated by surgical resection. Levels of immunoreactive EGFR and TGF-alpha were quantified by use of a computerized image analysis system and were normalized to appropriate standards. The logrank test and proportional hazards regression analysis were used to calculate the probability that EGFR and TGF-alpha levels were associated with disease-free survival (i.e., no recurrence of cancer) and cause-specific survival (i.e., patients do not die of their disease). All P values were two-sided.When tumor levels of EGFR or TGF-alpha were analyzed as continuous variables, disease-free survival and cause-specific survival were reduced among patients with higher levels of EGFR (both P = .0001) or TGF-alpha (both P = .0001). In a multivariate analysis, tumor site, tumor level of EGFR, and tumor level of TGF-alpha were statistically significant predictors of disease-free survival; in a similar analysis, regional lymph node stage and tumor levels of EGFR and of TGF-alpha were significant predictors of cause-specific survival.Quantitation of EGFR and TGF-alpha protein levels in primary head and neck squamous cell carcinomas may be useful in identifying subgroups of patients at high risk of tumor recurrence and in guiding therapy.
Evidence for specific suppression in the maintenance of immunologic tolerance.
Authors: D C Benjamin
Journal: The Journal of Experimental Medicine (1975)

Specific suppressor cells have been demonstrated in mice tolerant to the thymus-dependent antigen HGG. Transfer of normal thymocytes, normal spleen cells, or immune spleen cells into these tolerant mice did not restore immunocompetence to HGG. Furthermore, the transfer of tolerant spleen cells into normal recipients abrogated the response of these recipients to subsequent challenge with immunogenic HGG. Spleen cells removed from mice 5, 8, or 11 wk after the induction of tolerance specifically suppressed the response of normal spleen cells in an adoptive cell transfer system. The extent of suppression appears to be dependent upon how long after the induction of tolerance the cells were removed from the tolerant donors and how soon after transfer the recipients were challenged.
Laparoscopic Findings of the Liver in the Diagnosis of Primary Biliary Cirrhosis: “Reddish patch”, a Laparoscopic Feature in the Asymptomatic Stage
Authors: Y. Minami, K. Seki, M. Nishikawa, S. Kawata, S. Miyoshi, Y. Imai, S. Tarui, Y. Kakiuchi, Y. Shinji, G. Kiyonaga
Journal: Endoscopy (1982)

The laparoscopic findings of the livers of 12 patients with primary biliary cirrhosis (PBC), including six asymptomatic and six symptomatic cases, were investigated. On the liver surface of asymptomatic PBC, we found a laparoscopic appearance, consisting of reddish patches of irregular shape, ranging from 0.5 to 3 cm in diameter, and not evenly distributed. Five of six cases of asymptomatic PBC had reddish patches in our series. From serial laparoscopic observations, the patches were found to lose some of their reddish tone and to develop protuberances with vaguely outlined white markings in each reddish areas. The protuberances and white markings are characteristic appearances of the liver surface in more advanced PBC cases. The transition of reddish patches to protuberances with white markings coincided with progression among histopathological stages in PBC classified by Scheuer. A histometrical examination showed that areas with reddish patches had less advanced changes of intrahepatic bile ducts. As a result, we propose that laparoscopic findings of the liver have a value in the diagnosis of PBC and "reddish patch" is considered a laparoscopic feature which has no been described in asymptomatic PBC.
Do patient reported outcome measures do more harm than good?
Authors: M. Wolpert
Journal: BMJ (2013)

Black points out that patient reported outcome measures (PROMs) were developed for use in research and subsequently adopted to support clinical management.1 I have advocated the use of these measures in Child and Adolescent Mental Health Services (CAMHS) for the past decade (www.corc.uk.net). However, I have become increasingly worried that unless the tension between the two aims of data collection (informing generalisable findings …
Henry Richard Linderman, M.D.
Authors: Roy J. Popkin
Journal: New England Journal of Medicine (1959)

HENRY Richard Linderman, M.D., was a brilliant and conscientious public servant of whom the medical profession may be justly proud. His accomplishments as director of the United States Mint, advisor to Congress on its monetary and coinage laws, creator of the Trade Dollar and promoter of the doctrine of the gold standard were of paramount importance to the great industrial and commercial expansion of this country after the Civil War.He was born in Lehman township, Pike County, Pennsylvania, on December 25, 1825. His father, John Jordan Linderman, M.D., practiced medicine for many years in Pennsylvania. His mother was a . . .
Diagnosis of Syphilis Within Four Office or Clinical Visits
Authors: Nicholas J. Fiumara
Journal: JAMA (1963)

IT IS NOW APPARENT to even the most casual observer that syphilis is resurgent in the US. This rise has been seen in both private practice and public clinics. Primary and secondary syphilis, the two most infectious stages of this disease, have risen from a low of 6,323 reported cases in 1957 to 20,540 cases in 1962, an increase of 225%.<sup>1</sup>In 1962 the reported incidence of primary and secondary syphilis was only 20,540, but the actual incidence, based on the recently completed national survey by the American Social Health Association and the AMA was 68,976. This study shows also that three fourths of the cases of syphilis and gonorrhea occurring in this country are being treated by physicians in private practice in their own office. See also p 831 Syphilis can be controlled; but whether or not it is depends on the private physician. He is usually the
P228 Referral Patterns and Outcomes For Patients Treated in a National Centre Specialising in Weaning From Invasive Mechanical Ventilation
Authors: S Banerjee, M Pittman, R Chadwick, D Packer, N Oscroft, M Davies, J Shneerson, T Quinnell, I Smith
Journal: Thorax (2012)

<h3>Introduction</h3> With increasing evidence for the use of non-invasive ventilation (NIV) for acute COPD<sup>1</sup>, a change in referral pattern to a national weaning unit was anticipated over time. We investigated the case mix and outcomes of patients referred to a unit specialising in weaning from invasive mechanical ventilation (IMV) over a 20 year period, comparing sequential 5-year cohorts. <h3>Methods</h3> We undertook a retrospective analysis of 453 patient records referred to a national centre for weaning from IMV between January 1992 and December 2011. They were divided into four 5-year cohorts. Age on admission, gender, diagnostic group, length of stay on the weaning unit, survival, number successfully weaned from IMV and those requiring long term NIV at discharge were examined and compared between cohorts. <h3>Results</h3> <i>Figure 1. Kaplan Meier plot of post discharge survival, comparing the four 5-year cohorts.</i> A total of 453 patients were identified, 420 (93%) referred from other centres. Median age was 60.9 (IQR 49.6–70.2), 250 (55%) were male and median length of stay on the weaning unit was 27 days (IQR16–46). Thirty (7%) patients died before discharge. Of the survivors, 360 (79%) were weaned from IMV and 140 (31%) did not require any ventilatory support on discharge. No significant differences were found between the four cohorts in terms of age, gender, length of stay, proportions successfully weaned from IMV and requirement for NIV on discharge. There was no change in case mix, for example the proportions of patients with COPD were 18%, 23%, 26% and 22% across the four 5-year cohorts. <h3>Discussion</h3> We did not identify any change in the referral pattern to our weaning unit, despite widespread use of NIV. With rates of 79% successfully weaned from IMV and a median survival of 29.2 months (IQR 20.8–37.7) referral to our weaning centre remains highly relevant for those receiving prolonged IMV and good outcomes can be anticipated. <h3>References</h3> Ram FS, Picot J, Lightowler J, Wedzicha JA. Non-invasive positive pressure ventilation for treatment of respiratory failure due to exacerbations of COPD. Cochrane database 2004; (3): CD004104.
INDICATIONS AND CONTRAINDICATIONS OF ENCEPHALOGRAPHY AND VENTRICULOGRAPHY
Authors: EUGENE P. PENDERGRASS
Journal: JAMA (1931)

Many brain lesions give few or no localizing signs, even though they have been subjected to repeated thorough neurologic examinations. Dandy<sup>1</sup>states that approximately 40 per cent of brain tumors can be localized by neurologic methods and that assistance from the routine roentgen examinations of the head may be expected in only 10 to 15 per cent of the cases. Frazier<sup>2</sup>feels that Dandy's percentage of localization of brain tumors by neurologic methods is too low. He states that his percentage of localization is from 60 to 70 per cent by neurologic examinations without the aid of the roentgen examination. Cohen,<sup>3</sup>working in our laboratory, analyzed 221 cases of patients suffering from brain tumors who had been referred to us by the neurologic and neurosurgical divisions of the University Hospital for roentgen examinations of the head. The tumors of these patients were distributed as follows: Ninety-seven in
Resting energy expenditure should be measured in patients with cirrhosis, not predicted
Authors: Angela M. Madden, Marsha Y. Morgan
Journal: Hepatology (1999)

Measurements of resting energy expenditure (REE) can be used to determine energy requirements. Prediction formulae can be used to estimate REE but have not been validated in cirrhotic patients. REE was measured, by indirect calorimetry, in 100 cirrhotic patients and 41 comparable healthy volunteers, and the results compared with estimates predicted using the Harris-Benedict, Schofield, Mifflin, Cunningham, and Owen formulae, and the disease-specific Müller formula. The mean (+/- 1 SD) measured REE in the healthy volunteers (1,590 +/- 306 kcal/24 h) was significantly greater than the mean Harris-Benedict, Mifflin, Cunningham, and Owen predictions but comparable with the mean Schofield prediction; individual predicted values varied widely from measured values (95% limits of agreement, -460 to +424 kcal). The mean measured REE in the cirrhotic patients was significantly greater than in the healthy volunteers (23.2 +/- 3. 8 cf 21.9 +/- 2.9 kcal/kg/24 h; P <.05). The mean measured REE in the cirrhotic patients (1,660 +/- 337 kcal/24 h) was significantly different from mean predicted values (Harris-Benedict, 1,532 +/- 252 kcal/24 h, P <.0001; Schofield, 1,575 +/- 254 kcal/24 h, P <.0005; Mifflin, 1,460 +/- 254 kcal/24 h, P <.0001; Cunningham, 1,713 +/- 252 kcal/24 h, P <.05; Owen, 1,521 +/- 281 kcal/24 h, P <.0001; Müller, 1,783 +/- 204 kcal/24 h, P <.0001); individual predicted values varied widely from measured values (95% limits of agreement, -632 to +573 kcal). Simple regression analysis showed that fat-free mass (FFM) was the strongest predictor of measured REE in the cirrhotic patients, accounting for 52% of the variation observed. However, a population-specific prediction equation, derived using stepwise regression analysis, which incorporated FFM, age, and Pugh's score, accounted for only 61% of the observed variation in measured REE. REE should, therefore, be measured in cirrhotic patients, not predicted.
Incidence and Mortality From Early Stroke Associated With Acute Myocardial Infarction in the Prethrombolytic and Thrombolytic Eras
Authors: David Tanne, Shmuel Gottlieb, Hanoch Hod, Henrietta Reicher-Reiss, Valentina Boyko, Solomon Behar
Journal: Journal of the American College of Cardiology (1997)
A pilot study of inhaled nitric oxide in preterm infants treated with nasal continuous positive airway pressure for respiratory distress syndrome
Authors: Robert Lindwall, Mats Blennow, Mats Svensson, Baldvin Jonsson, Eva Berggren-Boström, Martino Flanby, Per-Arne Lönnqvist, Claes Frostell, Mikael Norman
Journal: Intensive Care Medicine (2005)
Self-limited TTP-like Syndrome After Bee Sting
Authors: Michael B. Jones, James O. Armitage, Daniel B. Stone
Journal: JAMA (1979)

THROMBOTIC thrombocytopenic purpura (TTP) is a complex, poorly understood syndrome diagnosed in patients with evidence of microangiopathic hemolytic anemia, thrombocytopenia, renal failure, neurological disease, and fever. The prognosis is poor. Occasionally patients survive after a variety of therapeutic maneuvers. We describe a patient who had the clinical pentad of the TTP syndrome following anaphylaxis secondary to a bee sting. She recovered completely without therapy. <h3>Report of a Case</h3> A 44-year-old woman was admitted to the hospital with complaints of anorexia, fatigue, jaundice, and severe retro-orbital headache. Seventy-two hours before admission, she was stung on the lower lip by a honeybee. She had previously been given Hymenopteran-whole-body-extract desensitization injections, but had stopped receiving them two years earlier. Because of three previous anaphylactic reactions from Hymenoptera stings, the patient had been taught to administer epinephrine hydrochloride subcutaneously to herself. Minutes after the sting in the present case, the patient lost consciousness and