tbuckley/cabot-search huggingface dataset:
The Comparative Clinical Effectiveness and Value of Simeprevir and Sofosbuvir for Chronic Hepatitis C Virus Infection
Authors: Daniel A. Ollendorf, Jeffrey A. Tice, Steven D. Pearson
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
The Pathogenesis of Atrioventricular Block in Coronary Disease
Authors: MAURICE LEV, SUMAN G. KINARE, ALFRED PICK
Journal: Circulation (1970)

The hypothesis that the pathogenesis of acute and chronic atrioventricular (A-V) block in coronary disease is different is investigated. The conduction systems of two cases of acute A-V block and four cases of chronic A-V block associated with coronary disease were studied by serial section. This showed that acute blocks in coronary disease are related to ischemia. Chronic blocks, however, have a mechanical factor associated with the ischemic factor. The mechanical factor is related to the effect of fibrosis and calcification of the summit of the ventricular septum upon the branching portion of the A-V bundle and the left bundle branch.
Conchal bowl skin grafting in nasal tip reconstruction: Clinical and histologic evaluation
Authors: Thomas E Rohrer, Leonard M Dzubow
Journal: Journal of the American Academy of Dermatology (1995)

Buckground: It is often difficult to achieve an esthetically pleasing cosmetic match when full-thickness skin grafts from periclavicular, preauricular, or postauricular donor sites are used to repair distal nasal defects.This, in large part, is due to the highly sebaceous nature of the skin on the distal aspect of the nose.Objective: Our purpose was to describe the benefits of using donor skin from the conchal bowl to repair defects of the nasal tip.Methods: The technique of conchal bowl grafting is described.Results: The conchal grafts give an excellent cosmetic result with respect to color and texture match and are time efficient because the donor site can be allowed to heal by secondary intention.Conclusion: The conchal bowl offers an esthetically reliable source of donor skin for fullthickness and perichondrial cutaneous grafts to repair defects of the nasal tip.
Endotracheal cuff pressure and tracheal mucosal blood flow: endoscopic study of effects of four large volume cuffs.
Authors: R D Seegobin, G L van Hasselt
Journal: BMJ (1984)

Large volume, low pressure endotracheal tube cuffs are claimed to have less deleterious effect on tracheal mucosa than high pressure, low volume cuffs. Low pressure cuffs, however, may easily be overinflated to yield pressures that will exceed capillary perfusion pressure. Various large volume cuffed endotracheal tubes were studied, including Portex Profile, Searle Sensiv, Mallinkrodt Hi-Lo, and Lanz. Tracheal mucosal blood flow in 40 patients undergoing surgery was assessed using an endoscopic photographic technique while varying the cuff inflation pressure. It was found that these cuffs when overpressurised impaired mucosal blood flow. This impairment of tracheal mucosal blood flow is an important factor in tracheal morbidity associated with intubation. Hence it is recommended that a cuff inflation pressure of 30 cm H2O (22 mm Hg) should not be exceeded.
Finger clubbing in inflammatory bowel disease: its prevalence and pathogenesis.
Authors: G Kitis, H Thompson, R N Allan
Journal: BMJ (1979)

Finger clubbing, measured objectively by using the hyponychial angle, was present in 75 out of 200 (38%) patients with Crohn9s disease, 15 out of 103 (15%) with ulcerative colitis, and two out of 24 (8%) with proctitis. In Crohn9s disease and ulcerative colitis the hyponychial angle was significantly correlated with both disease activity and the extent of fibrosis in the resected specimens from 47 surgically treated patients. The prevalence of finger clubbing in patients with macroscopic disease within the area of the gut innervated by the vagus nerve was significantly higher than that in patients in whom the disease was confined to the distal colon and rectum. Finger clubbing in patients with Crohn9s disease tended to regress after resection of macroscopic disease. It is concluded that finger clubbing is significantly commoner in Crohn9s disease than ulcerative colitis. The focal stimuli for finger clubbing include mucosal inflammatory change and fibrosis mediated by the vagus and possibly other autonomic pathways acting as the afferent arc of a finger-clubbing reflex.
Dysfunction in the βII Spectrin–Dependent Cytoskeleton Underlies Human Arrhythmia
Authors: Sakima A. Smith, Amy C. Sturm, Jerry Curran, Crystal F. Kline, Sean C. Little, Ingrid M. Bonilla, Victor P. Long, Michael Makara, Iuliia Polina, Langston D. Hughes, Tyler R. Webb, Zhiyi Wei, Patrick Wright, Niels Voigt, Deepak Bhakta, Katherine G. Spoonamore, Chuansheng Zhang, Raul Weiss, Philip F. Binkley, Paul M. Janssen, Ahmet Kilic, Robert S. Higgins, Mingzhai Sun, Jianjie Ma, Dobromir Dobrev, Mingjie Zhang, Cynthia A. Carnes, Matteo Vatta, Matthew N. Rasband, Thomas J. Hund, Peter J. Mohler
Journal: Circulation (2015)

Background— The cardiac cytoskeleton plays key roles in maintaining myocyte structural integrity in health and disease. In fact, human mutations in cardiac cytoskeletal elements are tightly linked to cardiac pathologies, including myopathies, aortopathies, and dystrophies. Conversely, the link between cytoskeletal protein dysfunction and cardiac electric activity is not well understood and often overlooked in the cardiac arrhythmia field. Methods and Results— Here, we uncover a new mechanism for the regulation of cardiac membrane excitability. We report that βII spectrin, an actin-associated molecule, is essential for the posttranslational targeting and localization of critical membrane proteins in heart. βII spectrin recruits ankyrin-B to the cardiac dyad, and a novel human mutation in the ankyrin-B gene disrupts the ankyrin-B/βII spectrin interaction, leading to severe human arrhythmia phenotypes. Mice lacking cardiac βII spectrin display lethal arrhythmias, aberrant electric and calcium handling phenotypes, and abnormal expression/localization of cardiac membrane proteins. Mechanistically, βII spectrin regulates the localization of cytoskeletal and plasma membrane/sarcoplasmic reticulum protein complexes, including the Na/Ca exchanger, ryanodine receptor 2, ankyrin-B, actin, and αII spectrin. Finally, we observe accelerated heart failure phenotypes in βII spectrin–deficient mice. Conclusions— Our findings identify βII spectrin as critical for normal myocyte electric activity, link this molecule to human disease, and provide new insight into the mechanisms underlying cardiac myocyte biology.
Serum Ferritin in Hyperthyroidism
Authors: Massimo Delfino
Journal: Annals of Internal Medicine (1993)

Letters1 August 1993Serum Ferritin in HyperthyroidismMassimo Delfino, MDMassimo Delfino, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-3-199308010-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Determination of serum ferritin levels is useful for estimating iron stores. In iron-deficient anemia, the ferritin level is very low, whereas in hemochromatosis [1], hepatitis, and many malignancies, it is high. Elevated ferritin levels have been recently observed in patients with hyperthyroidism [2, 3], but levels decreased after thyroid function returned to normal [4].Recently, we hospitalized a 72-year-old monk with atrial fibrillation. He had had hyperthyroidism for 20 years, and his treatment had been irregular, never lasting more than a few days. At examination, he showed signs of thyrotoxicosis. Serum iron, ferritin, and transferrin saturation levels ...References1. Niederau C, Stremmel W, Strohmeyer G. Serum ferritin and hemochromatosis. Dtsch Med Wochenschr. 1991; 116:313-4. Google Scholar2. Macaron CI, Macaron ZG. Increased serum ferritin levels in hyperthyroidism. Ann Intern Med. 1982; 96:617-8. Google Scholar3. Iwasa Y, Aida K, Yokomori N, Inove M, Onaya T. Transcriptional regulation of ferritin heavy chain messenger RNA expression by thyroid hormone. Biochem Biophys Res Commun. 1990; 167:1279-85. Google Scholar4. Takamatsu J, Majima M, Miki K, Kuma K, Mozaj T. Serum ferritin as a marker of thyroid hormone action on peripheral tissues. J Clin Endocrinol Metab. 1985; 61:672-6. Google Scholar5. Worwood M. Ferritin. Blood Rev. 1990; 4:259-69. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAtteintes hépatique et cutanée chez une patiente traitée par antithyroïdien, révélatrices d’une hémochromatose et d’une porphyrie cutanée tardiveCORRESPONDENCEL’hyperthyroïdie : une cause d’élévation de la ferritine sérique 1 August 1993Volume 119, Issue 3Page: 249KeywordsFerritinHemochromatosisHyperthyroidismSerum ferritin levelsTestosteroneThyroidThyroid hormonesThyroid-stimulating hormoneTotal iron binding capacityUrine Issue Published: 1 August 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Endogenous adenosine does not activate ATP-sensitive potassium channels in the hypoxic guinea pig ventricle in vivo.
Authors: J Xu, L Wang, C M Hurt, A Pelleg
Journal: Circulation (1994)

BACKGROUND The activation of ATP-sensitive K+ (K+ ATP) channels by K+ ATP openers, eg, pinacidil, hypoxia, and ischemia, is known to shorten the ventricular action potential. Since adenosine is released in increased amounts during cardiac hypoxia and ischemia, the hypothesis that endogenous adenosine activates K+ ATP channels was tested in vivo in a guinea pig model. METHODS AND RESULTS Anesthetized animals (n = 37) were subjected to transient acute global hypoxia by ventilation with 100% N2. Monophasic action potentials (MAP) were recorded in ventricular and atrial myocardium by use of custom-made Ag/AgCl electrode catheters. In addition, right atrial and left ventricular electrograms as well as systemic arterial blood pressure were monitored throughout the experiments. Under normoxic conditions, pinacidil (1.8 microgram/kg i.v., n = 8), a K+ ATP channel opener, shortened ventricular MAP duration (APD); this effect was reversed by glibenclamide, a potent K+ ATP channel blocker, but not by 8-cyclopentyl-1,3-dimethylxanthine (CPT), a potent A1-selective adenosine antagonist. Global hypoxia shortened atrial and ventricular APD. Glibenclamide but not CPT reversed this effect of hypoxia on ventricular but not atrial MAP. CPT but not glibenclamide reversed the effect of hypoxia on atrial MAP. In addition, CPT delayed the appearance of the atrioventricular (AV) nodal conduction block associated with global hypoxia. Finally, the ability of CPT to selectively attenuate A1-adenosine receptor-mediated effects of adenosine agonists in ventricular and supraventricular tissues was confirmed in 17 animals. CPT reversed the negative dromotropic effect of adenosine on AV nodal conduction and the antiadrenergic effect of N6-cyclopentyladenosine (CPA) mediated by A1-adenosine receptor but not the adenosine-induced decrease in systemic blood pressure caused by the vasodilatory action of the nucleoside mediated by A2-adenosine receptor. CONCLUSIONS (1) Endogenous adenosine released during global cardiac hypoxia mediates, in part, AV nodal conduction delay and shortening of atrial but not ventricular APD. (2) The action of adenosine on atrial APD is mediated by A1 adenosine receptors, probably via IK,Ado,Ach. (3) Endogenous adenosine apparently does not play an important role in the early stages of acute global hypoxia-induced activation of K+ ATP channels. The present results are consistent with the hypothesis that the shortening of ventricular APD in the hypoxic heart is due, in part, to activation of K+ ATP channels.
1001-37 Strain rate imaging differentiates myocardial hypertrophy induced either by arterial hypertension or aortic stenosis
Authors: Frank Weidemann, Kerstin Harre, Bjoem Lengenfelder, Oliver Turschner, Jacques Blondelot, Wolfram Voelker, Georg Ertl, Joerg M Strotmann
Journal: Journal of the American College of Cardiology (2004)
Preventing venous thromboembolism in elderly patients with hip fractures: studies of low-dose heparin, dipyridamole, aspirin, and flurbiprofen.
Authors: G K Morris, J R Mitchell
Journal: BMJ (1977)

Low-dose heparin, dipyridamole (alone and in combination with aspirin), and flurbiprofen were evaluated as potential prophylactic agents against deep venous thrombosis in elderly patients with hip fractures. None of the agents that modify platelet behaviour could reduct the frequency of isotopically diagnosed venous thrombosis. Low-dose heparin reduced the overall frequency of venous thrombosis and its extent as judged by the frequency of bilaterally abnormal scans, but this reduction did not achieve statistical significance.
Diagnosing Pheochromocytoma in von Hippel-Lindau Disease
Authors: Mumtaz A. Siddiqui
Journal: Annals of Internal Medicine (1994)

Letters15 September 1994Diagnosing Pheochromocytoma in von Hippel-Lindau DiseaseMumtaz A. SiddiquiMumtaz A. SiddiquiThe Graduate Hospital, Philadelphia, PA 19146Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-6-199409150-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The report by Aprill and colleagues [1] stresses the importance of silent adrenal nodules and pheochromocytomas in Lindau disease. Computed tomographic (CT) scan appearance, although as variable as pheochromocytoma pathologic findings, is fairly accurate for diagnosis [2]. The report does not describe any features of the adrenal nodules. Also, there is a disparity between the nodule size shown in the CT scan and that shown by the surgical pathologic findings. In a tumor that is known for its well-encapsulated nature [3], this would indicate a false-positive CT scan of the “silent nodules.” The only differentiation between a ...References1. Aprill BS, Drake AJ III, Lasseter DH, Shakir KM. Silent adrenal nodules in von Hippel-Lindau disease suggest pheochromocytoma. Ann Intern Med. 1994; 120:485-7. Google Scholar2. Dunnick NR, Schaner EG, Doppman JL, Strott CA, Gill JR, Javadpour N. Computed tomography in adrenal tumors. AJR Am J Roentgenol. 1979; 132:43-6. Google Scholar3. Rossi J. Ackerman's Surgical Pathology. 7th ed. St. Louis: C. V. Mosby Company; 1989:806. Google Scholar4. Mahoney EM, Harrison JH. Malignant pheochromocytoma. Clinical course and treatment. J Urol. 1977; 118:225-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: The Graduate Hospital, Philadelphia, PA 19146 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMultiple Pheochromocytomas in a Patient With Blurred Vision 15 September 1994Volume 121, Issue 6Page: 465-466KeywordsBoneComputed axial tomographyLiverLungsLymph nodesPheochromocytoma Issue Published: 15 September 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The birth of eARD
Authors: M. DOHERTY
Journal: Annals of the Rheumatic Diseases (1999)

We are pleased to announce that from 2 April 1999 Annals of the Rheumatic Diseases will have a full text web site available at our current address—www.annrheumdis.com. The name of the electronic version of the journal is e ARD. 





A greatly expanded range of services can now be accessed at this site. Firstly, e ARD will provide full onscreen text of current issues, including figures and tables. In addition, there is a fully searchable archive going back to …
Incidental Demonstration of Tc-99m MDP Uptake in Gallstones
Authors: SHOBHA DESAI, SUSAN FREEMAN
Journal: Clinical Nuclear Medicine (1994)

A 51-year old female with a history of hyperparathyroidism and an ovarian mass underwent a Tc-99m MDP bone scan for metastatic work up. Imaging results showed two small foci of increased activity in the right upper quadrant. Plain radiographs and ultrasound of the abdomen revealed two free floating gallstones.
Letter: Fluorinated corticosteroids and dermatophytosis.
Authors: J N Burry
Journal: BMJ (1975)

understand immunity to erytshocytic malaria, and it is far from simple.What we just do not know is how to identify and produce in bulk the appropriate antigen(s) of experi- mental malarias, let alone of P. falciparum and other human parasites.Nor do we know -how to present these antigens in a way which stimulates the inmnune system to best advantage without using Draconian adjuvants like F.CA.When we have solved these fomidable problems a practical vaccine in- corprating blood stage antigens might become feasible.-Iam, etc.,
Effects of tyrosine kinase inhibitors alone or in combination with vaccine on tumor-infiltrating myeloid cells
Authors: Renee N Donahue, Italia Grenga, Jeffrey Schlom, Benedetto Farsaci
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Tyrosine kinase inhibitors (TKIs) are considered good candidates for combination with cancer immunotherapy due to their ability to decrease myeloid-derived suppressor cells (MDSCs) in peripheral blood. However, very little is known about the effects of TKIs on myeloid cells in the
Diagnosis and Treatment of Seborrheic Keratosis
Authors: Stefan E. Epstein
Journal: JAMA (1991)

To the Editor.—  I have reviewed the article by Stern et al 1 from the point of view of a practicing pathologist not in a university teaching center. Some of the assumptions and underlying premises of the study are worrisome.  First, in reviewing the list of clinical diagnoses that are considered correct, I feel rather strongly that senile wart, squamous papilloma, inverted follicular keratosis, and, especially, senile keratosis are inappropriate as clinical diagnoses for proven seborrheic keratoses. The problem with this spectrum of diagnoses that the authors consider  is that those such as senile wart and senile keratosis are different from seborrheic keratosis, implying both different treatment and prognostic evaluation.  In reviewing my own files, it is clear that, if I exclude clinical diagnoses of pigmented mole and basal cell epithelioma, virtually all of the clinical diagnoses submitted to me for skin tumors would be correct for seborrheic keratosis
Linear IgA disease: a report of two dermal binding sera which recognize a pepsin-sensitive epitope (?NC-1 domain) of collagen type VII
Authors: J. ALLEN, S. ZHOU, S.H. WAKELIN, P.M. COLLIER, F. WOJNAROWSKA
Journal: British Journal of Dermatology (1997)

Linear IgA disease is a subepidermal blistering disease characterized by IgA autoantibody deposition at the basement membrane zone of skin and mucosa. The antigens targeted in linear IgA disease have been defined by their molecular weight and localization. It has been proposed that a minority of linear IgA disease sera that bind to the dermal aspect of salt-split skin target collagen type VII. We have identified two patients with linear IgA disease using dermal binding IgA autoantibodies on salt-split skin which recognize collagen type VII by immunoblot analysis. The reactive epitope was destroyed by the proteolytic enzymes pepsin, which destroys the NC-1 domain of collagen type VII, and protease type VIII. Localization studies compared the IgA autoantibodies from these patients with the monoclonal antibody LH7.2 to the NC-1 domain of collagen type VII and showed colocalization on a dermal cylindroma tumour tissue, and a similar distribution with immunogold electron microscopy, using purified blister fluid from one patient. We propose from these results that the IgA autoantibodies from these two patients recognize the NC-1 domain of collagen type VII, the classical immunodominant epitope for epidermolysis bullosa acquisita.
Doctors should accept they are no longer primary decision makers in care, says think tank
Authors: A. O'Dowd
Journal: BMJ (2013)

Doctors have to change their view of themselves as the primary decision makers in care and shift to a partnership model that allows patients to play an active part in determining their own care, a health think tank has said.

The King’s Fund claims that it is time for a new approach to caring for people with long term conditions that involves doctors being more proactive and preventive in their approach.

In a report1 on the management of long term conditions published on 2 October, the think tank says that …