Carbon Dioxide Tension and Ventilatory Mechanics in Chronic Obstructive Lung Disease
Authors: BENJAMIN BURROWS
Journal: Annals of Internal Medicine (1966)

Article1 October 1966Carbon Dioxide Tension and Ventilatory Mechanics in Chronic Obstructive Lung DiseaseBENJAMIN BURROWS, M.D., FRANKLIN B. SAKSENA, M.D., CARL F. DIENER, M.D.BENJAMIN BURROWS, M.D.Search for more papers by this author, FRANKLIN B. SAKSENA, M.D.Search for more papers by this author, CARL F. DIENER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-4-685 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPatients with irreversible airways obstruction of uncertain etiology present a diversity of clinical, physiological, and even pathological findings, and one feature that shows great variability is the tendency to carbon dioxide retention. The present report, which is based on studies of ventilatory mechanics in 34 patients, attempts to explain this variability. The study is divided into three parts.First, Pco2is correlated with ventilatory characteristics. Although confirming the observations of Gilbert, Keighley, and Auchincloss (1) that hypercapnia (or alveolar hypoventilation) is more closely related to a high fraction of dead space ventilation than to a low total minute volume, present...References1. GILBERTKEIGHLEYAUCHINCLOSS RJJH: Mechanisms of chronic carbon dioxide retention in patients with obstructive pulmonary disease. Amer. J. Med. 38: 217, 1965. CrossrefMedlineGoogle Scholar2. BURROWSSTRAUSSNIDEN BRHAH: Chronic obstructive lung disease. III. Interrelationships of pulmonary function data. Amer. Rev. Resp. Dis. 91: 861, 1965. MedlineGoogle Scholar3. KAHANAARANOVITCHPLACE LMMR: A comparative study of the clinical and functional pattern in emphysematous patients with and without chronic respiratory failure. Amer. Rev. Resp. Dis. 87: 699, 1963. MedlineGoogle Scholar4. 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Author, Article, and Disclosure InformationAuthors: BENJAMIN BURROWS, M.D.; FRANKLIN B. SAKSENA, M.D.; CARL F. DIENER, M.D.Affiliations: Chicago, IllinoisFrom the Department of Medicine, University of Chicago, Chicago, Ill.This study was supported by grant HE-04109, the U. S. Public Health Service, Washington, D. C., and in part by a grant from the Council for Tobacco Research. Patients were hospitalized in the Clinical Research Center of the University of Chicago, supported by grant OG-37, the U. S. Public Health Service, and computation was accomplished with the assistance of the Biological Sciences Computation, University of Chicago, under grant FR-00013, the U. S. Public Health Service.Requests for reprints should be addressed to Benjamin Burrows, M.D., University of Chicago, Department of Medicine, 950 E. 59th St., Chicago, Ill. 60637. 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GRANT, M.D., F.A.C.P., EUGENE LUCIER, M.D., MARK L. MAHNKE, M.D.Drive and Performance of the Ventilatory Apparatus in Chronic Obstructive Lung DiseaseEfficacy of a new bronchodilator, soterenol, on experimental locked-lung syndrome in dogsBLOOD-GAS TENSION AND SPIROMETRIC FINDINGSSHINGLESCHRONIC OBSTRUCTIVE LUNG DISEASE 1 October 1966Volume 65, Issue 4Page: 685-700KeywordsCarbon dioxideEtiologyHypercapniaLungsMedical servicesPartial pressure of carbon dioxidePathogenesisRespirationSoftware toolsTachypnea ePublished: 1 December 2008 Issue Published: 1 October 1966 PDF downloadLoading ...