tbuckley/cabot-search huggingface dataset:
Reviews, Notes, and Listings: The Fragile Species
Authors: William J. Pomidor
Journal: Annals of Internal Medicine (1993)

Literature of Medicine1 February 1993Reviews, Notes, and Listings: The Fragile SpeciesWilliam J. Pomidor, MDWilliam J. Pomidor, MDNortheastern Ohio Universities College of Medicine, Rootstown, OH 44272.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-3-199302010-00043 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Fragile SpeciesLewis Thomas. 193 pages. New York: Charles Scribner's Sons; 1992. $20.00.Lewis Thomas claims that “the most beautiful object I have ever seen in a photograph, in all my life, is the planet Earth seen from the distance of the moon, hanging there in space and obviously alive.” The author of Lives of a Cell: Notes of a Biology Watcher and The Youngest Science explores several familiar themes in his latest book: evolution, communication, the interrelatedness and interdependency of life on earth. This collection of writings and lectures, however, is more cohesive than some of his previous works. Each ... Author, Article, and Disclosure InformationAffiliations: Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1993Volume 118, Issue 3Page: 237KeywordsAIDSAdolescentsAnxietyBacteriaCell biologyCell communicationConsciousnessDrug abuseMitochondria ePublished: 15 August 2000 Issue Published: 1 February 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
L-selectin-negative CCR7− effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells
Authors: Greta Guarda, Miroslav Hons, Silvia F Soriano, Alex Y Huang, Rosalind Polley, Alfonso Martín-Fontecha, Jens V Stein, Ronald N Germain, Antonio Lanzavecchia, Federica Sallusto
Journal: Nature Immunology (2007)
Phase I Study of High-Dose Continuous-Infusion Recombinant Interleukin-2 and Autologous Lymphokine-Activated Killer Cells in Patients With Metastatic or Unresectable Malignant Melanoma and Renal Cell Carcinoma
Authors: E. R. Gaynor, G. R. Weiss, K. A. Margolin, F. R. Aronson, M. Sznol, P. Demchak, K. M. Grima, R. I. Fisher, D. H. Boldt, J. H. Doroshow, M. H. Bar, M. J. Hawkins, J. W. Mier, G. Caliendo
Journal: JNCI Journal of the National Cancer Institute (1990)

The current study was undertaken to determine the maximum tolerated dose of recombinant interleukin-2 (rIL-2) that could be administered as a continuous infusion in conjunction with autologous lymphokine-activated killer (LAK) cells. All 55 patients in this study received a priming dose of rIL-2 of 1.0 mg/m 2 per day given as a continuous infusion over 4.5 days. Patients later received (days 11–16) one of three doses of rIL-2 per day (1.0, 1.25, or 1.50 mg/m 2 ) in conjunction with LAK cells given on days 11, 12, and 14. Because of unacceptable toxicity occurring early in the LAK cell phase of therapy at the rIL-2 dose level of 1.50 mg/m 2 , we concluded that the maximum tolerated dose of rIL-2 given as a continuous infusion with LAK cells is 1.25 mg/m 2 per day. [J Natl Cancer Inst 82: 1397–1402, 1990]
Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice.
Authors: S Levak-Frank, H Radner, A Walsh, R Stollberger, G Knipping, G Hoefler, W Sattler, P H Weinstock, J L Breslow, R Zechner
Journal: Journal of Clinical Investigation (1995)

In extrahepatic tissues lipoprotein lipase (LPL) hydrolyzes triglycerides thereby generating FFA for tissue uptake and metabolism. To study the effects of increased FFA uptake in muscle tissue, transgenic mouse lines were generated with a human LPL minigene driven by the promoter of the muscle creatine kinase gene. In these mice human LPL was expressed in skeletal muscle and cardiac muscle, but not in other tissues. In proportion to the level of LPL overexpression, decreased plasma triglyceride levels, elevated FFA uptake by muscle tissue, weight loss, and premature death were observed in three independent transgenic mouse lines. The animals developed a severe myopathy characterized by muscle fiber degeneration, fiber atrophy, glycogen storage, and extensive proliferation of mitochondria and peroxisomes. This degree of proliferation suggests that FFA play an important role in the biogenesis of these organelles. Our experiments indicate that LPL is rate limiting for the supply of muscle tissue with triglyceride-derived FFA. Improper regulation of muscle LPL can lead to major pathological changes and may be important in the pathogenesis of some human myopathies. Muscle-specific LPL transgenic mouse lines will serve as a useful animal model for the investigation of myopathies and the biogenesis of mitochondria and peroxisomes.
New GMC guidance takes a major, ethically flawed, backward step
Authors: I. Roberts, B. Chaudhry, I. Chalmers
Journal: BMJ (2013)

Doctors and patients have good reason not to be enamoured with new General Medical Council (GMC) guidance.1 Whereas the 2006 edition of Good Medical Practice stated that doctors “must work with colleagues and patients . . . to help resolve uncertainties about the effects of treatments” (para 14f),2 this principle and the relevant paragraph have …
Our Two Cents: Research Ethics Consultation at Johns Hopkins Bloomberg School of Public Health
Authors: Holly A. Taylor, Nancy E. Kass
Journal: The American Journal of Bioethics (2008)

Click to increase image sizeClick to decrease image size Notes 1. The Program in Research Ethics (PRE) is comprised of faculty of the Berman Institute of Bioethics who serve on one of the seven IRBs serving the JHU Schools of Medicine and Public Health, as well as Berman Institute of Bioethics faculty who engage in significant research and/or teaching related to research ethics. PRE brings these faculty together monthly to discuss challenging issues in research ethics and/or IRB function; to identify and collaborate on scholarly projects related to research ethics; and to provide service with regard to research ethics policies and/or IRB procedures to the JHU Schools of Medicine and Public Health. 2. In addition to providing start up funds for the RECS, funds from the OHRP/DHHS were also used to fund the placement of an Berman Institute of Bioethics faculty member on all IRBs serving the JHU Schools of Medicine and Public Health.
<i>The Statue of Liberty in Frédéric-Auguste Bartholdi’s Studio, Paris</i>
Authors: Thomas B. Cole
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hepatic veno‐occlusive disease after tranexamic acid administration in patients undergoing allogeneic hematopoietic stem cell transplantation
Authors: Takehiko Mori, Yoshinobu Aisa, Takayuki Shimizu, Rie Yamazaki, Ai Mihara, Tomoharu Yajima, Toshifumi Hibi, Yasuo Ikeda, Shinichiro Okamoto
Journal: American Journal of Hematology (2007)

Tranexamic acid is one of the widely used antifibrinolytic agents. In spite of its effective inhibitory activity against plasminogen, thromboembolic adverse events caused by tranexamic acid are rare. We encountered three recipients of allogeneic hematopoietic stem cell transplantation (HSCT) who developed hepatic veno-occlusive disease (VOD) shortly after the administration of tranexamic acid. Hepatic VOD was resolved completely in all patients with the discontinuation of the drug, and with supportive measures with or without intravenous tissue plasminogen activator administration. These findings suggest that administration of tranexamic acid could be one of the possible risk factors for developing hepatic VOD in HSCT recipients.
Mushroom worker's lung
Authors: E. Jackson, K. M. A. Welch
Journal: Thorax (1970)

Two cases of an acute chest illness occurring in mushroom workers are described. In one patient, who was severely ill, a lung biopsy was obtained which showed a pattern of alveolitis and interstitial fibrosis. The serum of both patients gave a precipitin reaction to an extraction of mushroom compost after spawning, but no reaction occurred to a variety of hay antigens used in the diagnosis of farmer9s lung. A provocation test undertaken in one patient demonstrated a reaction to the inhalation of a dilute extract of mushroom compost after spawning. The most severely ill patient made a full clinical and functional recovery without steroid therapy.
Elimination and rearrangement of parental rDNA in the allotetraploid Nicotiana tabacum
Authors: R. A. Volkov, N. V. Borisjuk, I. I. Panchuk, D. Schweizer, V. Hemleben
Journal: Molecular Biology and Evolution (1999)

Origin and rearrangement of ribosomal DNA repeats in natural allotetraploid Nicotiana tabacum are described. Comparative sequence analysis of the intergenic spacer (IGS) regions of Nicotiana tomentosiformis (the paternal diploid progenitor) and Nicotiana sylvestris (the maternal diploid progenitor) showed species-specific molecular features. These markers allowed us to trace the molecular evolution of parental rDNA in the allopolyploid genome of N. tabacum; at least the majority of tobacco rDNA repeats originated from N. tomentosiformis, which endured reconstruction of subrepeated regions in the IGS. We infer that after hybridization of the parental diploid species, rDNA with a longer IGS, donated by N. tomentosiformis, dominated over the rDNA with a shorter IGS from N. sylvestris; the latter was then eliminated from the allopolyploid genome. Thus, repeated sequences in allopolyploid genomes are targets for molecular rearrangement, demonstrating the dynamic nature of allopolyploid genomes.
The Response of Extracellular Hydrogen Ion Concentration to Graded Degrees of Chronic Hypercapnia: The Physiologic Limits of the Defense of pH*
Authors: William B. Schwartz, Newton C. Brackett, Jordan J. Cohen
Journal: Journal of Clinical Investigation (1965)

It is now well recognized that the defense of extracellular pH during acute hypercapnia de- pends upon generation of bicarbonate by body buffers (1).Recently, the quantitative charac- teristics of this defense have been defined in acute studies of the acid-base response of the intact organism to stepwise increases in carbon dioxide tension (2, 3).Similar observations are not available, however, for chronic hypercapnia in which defense of pH is enhanced by renal gen- eration of bicarbonate.The present study was undertaken to define the chronic adjustments of acid-base equilibrium in normal dogs subjected to stepwise elevations of arterial carbon dioxide tension to levels as high as 125 mm Hg.Observations have been carried out in an environmental chamber over a period of time sufficient to allow establishment of a steady state at each of three successive levels of carbon dioxide tension.The data demonstrate a highly reproducible bicarbonate response curve, the in- crement in extracellular bicarbonate concentration increasing notably in response to each stepwise elevation of Pco2.At no point was this in- crement sufficient to restore extracellular pH to normal; there was, however, a striking linearity in the relationship between hydrogen ion con- centration and Pco2.These data indicate that extracellular acidity is defended with a virtually constant degree of effectiveness over the entire
Clinical Judgment Revisited: The Distraction of Quantitative Models
Authors: Alvan R. Feinstein
Journal: Annals of Internal Medicine (1994)

More than 25 years ago, in a book called Clinical Judgment, each act of patient care was described as having an experimental structure.The "experiments" needed substantial scientific improvement, however, in quality of basic data, taxonomic classification of phenomena, and specifications of clinical reasoning. During the past 2 decades, these improvements have not occurred as extensively as expected because many investigators working in clinical forms of clinical research have not addressed these basic scientific challenges in data, taxonomy, and reasoning. Instead, the investigators have applied quantitative "models," derived from non-clinical domains, that focus on hard data, randomized trials, Bayes theorem, quantitative decision analysis, and psychometric strategies for clinimetric measurement. Consequently, the main challenges of clinical judgment still remain generally available for basic scientific research by investigative clinicians.
Comparison of cellular gene expression in Ebola-Zaire and Ebola-Reston virus-infected primary human monocytes
Authors: C. Xiang, H. Young, H. Alterson, D. Reynolds, M. Bittner, Y. Chen, G. Gooden, Y. Jiang, P. Meltzer, J. Trent, J. Mikovits, K. Anderson
Journal: Nature Genetics (1999)
Chronic bronchitis: is bacteriological examination of sputum necessary?
Authors: I C Paterson, G R Petrie, G K Crompton, J R Robertson
Journal: BMJ (1978)

TABLE iII-Antibiotic resistance pattern of strains of Staph aureus isolated from patients who had received an antibiotic.Number of patients in parentheses Antibiotic No of patients Resistance patterns* Penicillin .. .10
Myocardial blood flow and O2-supply following dextran-haemodilution and methaemoglobinaemia in the dog
Authors: G. P. BIRO, D. BERESFORD-KROEGER
Journal: Cardiovascular Research (1979)

The adequacy of oxygen-supply to the left ventricular myocardium was compared in anaesthetised dogs following: a) isovolaemic haemodilution with Dextran 70 (to haematocrit =20± 2%), b) the acute induction of methaemoglobinaemia (to methaemoglobin-concentration = 53 ± 7%, by subjecting them to an exchange-transfusion with methaemoglobin-containing erythrocytes in dextran) and c) a control exchange-transfusion with normal homologous erythrocytes in dextran. Myocardial oxygen-supply was assessed by the measurement of myocardial blood flow (using 15 ±5 μm microspheres) and of the PO2 in coronary sinus blood. In dextran-haemodiluted dogs, mean myocardial blood flow was 92% greater than in the control group, allowing the maintenance of normal coronary sinus PO2. In the methaemoglobinaemic group, flow was only 15% greater than in the control group; because oxygen-capacity was halved in this group, myocardial oxygen-supply was impaired and coronary sinus PO2 fell. Infusions of isoproterenol (0.1 μg·kg−1·min1) produced similar myocardial flow-increments in the haemodiluted and control groups with similar transmural distribution. In the methaemoglobinaemic group, however, the subendocardial flow-increment was reduced, in association with a further reduction in coronary sinus PO2 and an attenuated contractile response to the drug. These findings suggest that the rheological effects of haemodilution play an important role in the maintenance of myocardial oxygen-supply, but in significant methaemoglobinaemia, the oxygen supply of the myocardium may be severely curtailed.
Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation
Authors: Nicola Gökbuget, Daniel Stanze, Joachim Beck, Helmut Diedrich, Heinz-August Horst, Andreas Hüttmann, Guido Kobbe, Karl-Anton Kreuzer, Lothar Leimer, Albrecht Reichle, Markus Schaich, Stefan Schwartz, Hubert Serve, Michael Starck, Matthias Stelljes, Reingard Stuhlmann, Andreas Viardot, Knut Wendelin, Mathias Freund, Dieter Hoelzer
Journal: Blood (2012)
Funding family planning
Authors: B Harradine
Journal: BMJ (1994)

to prove what.There is a legal maxim that "he who asserts must prove."The person who asserts is the person who seeks to change the status quo.If junior doctors want their hours to be reduced they must prove that long hours are unnecessary for training or dangerous to health, or both.Poulsen cites anecdotal evidence, the recommendations of committees, and journal articles but fails to pro- duce any scientifically valid evidence to support either proposition.The House of Lords considered the proposed directive on working hours in 1990.The Lords commented that evidence on the effects of excessive working hours was conflicting and that more research was needed.2Common sense suggests that worldng excessive hours is bad for you.But if
Endothelial Junctional Adhesion Molecule-A Guides Monocytes Into Flow-Dependent Predilection Sites of Atherosclerosis
Authors: Martin M.N. Schmitt, Remco T.A. Megens, Alma Zernecke, Kiril Bidzhekov, Nynke M. van den Akker, Timo Rademakers, Marc A. van Zandvoort, Tilman M. Hackeng, Rory R. Koenen, Christian Weber
Journal: Circulation (2013)

Background— Junctional adhesion molecule (JAM)-A expressed in endothelial, epithelial, and blood cells can regulate permeability and leukocyte extravasation. Atherosclerosis develops at sites of disturbed flow in large arteries, but the mechanisms guiding inflammatory cells into these predilection sites remain unknown. Methods and Results— To characterize cell-specific functions of JAM-A in atherosclerosis, we used apolipoprotein E–deficient mice with a somatic or endothelium-specific deficiency in JAM-A and bone marrow chimeras with JAM-A–deficient leukocytes. We show that impaired JAM-A expression in endothelial cells reduced mononuclear cell recruitment into the arterial wall and limited atherosclerotic lesion formation in hyperlipidemic mice. In contrast, JAM-A deficiency in bone marrow cells impeded monocyte de-adhesion, thereby increasing vascular permeability and lesion formation, whereas somatic JAM-A deletion revealed no significant effects. Regions with disturbed flow displayed a focal enrichment and luminal redistribution of endothelial JAM-A and were preferentially protected by its deficiency. The functional expression and redistribution of endothelial JAM-A was increased by oxidized low-density lipoprotein, but confined by atheroprotective laminar flow through an upregulation of microRNA (miR)-145, which repressed JAM-A. Conclusions— Our data identify endothelial JAM-A as an important effector molecule integrating atherogenic conditions to direct inflammatory cell entry at predilection sites of atherosclerosis.
The ??Hot Halo?? Sign
Authors: DAVID B. COUPLAND, BLAKE TERRIFF, ANTHONY Y-F FUNG, CRAIG SARTORI
Journal: Clinical Nuclear Medicine (1992)

The authors report a patient with diffuse pyogenic pericarditis and focal myoendocarditis initially detected using In-111 WBC scintigraphy. The patient was in septic shock after hemodialysis for the treatment of chronic renal failure. This was preceded by clinical signs and symptoms of pericarditis thought to be viral in nature. Initial investigations found no septic focus, and the patient was referred for In-111 WBC scintigraphy. This revealed a striking "halo" of increased activity around the heart, strongly suggesting bacterial pericarditis. A subsequent pericardiocentesis yielded 400 ml of purulent material, confirming the diagnosis.
Reduction of antithrombin III, protein C, and protein S levels and activated protein C resistance in polycythemia vera and essential thrombocythemia patients with thrombosis
Authors: Alessandro Bucalossi, Giuseppe Marotta, Catia Bigazzi, Piero Galieni, Egidio Dispensa
Journal: American Journal of Hematology (1996)

Patients with polycythemia vera (PV) or essential thrombocythemia (ET) show a high frequency of thrombosis. The reduction of hematocrit after phlebotomy and normalization of platelet counts do not completely eliminate thrombotic risk. Some preliminary studies reported a reduction in the concentration of natural anticoagulants (NA) in this group of patients. For this reason we evaluated protein S (PS) total antigen, antithrombin III (AT III), and protein C (PC) activity in 81 patients with chronic myeloproliferative disorders (33 with PV and 48 with ET). Data were compared with those obtained in 70 healthy sex- and age-matched subjects. Fifty-seven percent of patients (46 out of 81) showed one or more thrombotic episodes at diagnosis or during follow-up. Interestingly, we found a NA deficit in 43.5% of patients with thrombosis versus only 5.7% in the group of patients without thrombosis. These results may suggest new interpretations about the pathogenesis of thrombosis in PV or ET patients. © 1996 Wiley-Liss, Inc.
Gray Cats: Black Cats
Authors: Neill F. David
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Kamholtz's letter about GRAY cats (227:558, 1974) leaves something to be desired. Erudite withal, the writer fails to mention BLACK cats—black, lovable, amiable, cuddly, and kind—maligned unreasonably in folklore as demoniacal crossers of one's path. Not so! Let a black cat cross your path, befriend it as a stray, and you have a life-long (nine lives) companion. As a benefactor of 43 black cats—all male—I take great joy in their companionship. Yet, they seem somehow discontent, or uneasy, or unfulfilled. Heretofore, I have kept them at the hearthside. Should I let them loose upon the GRAYS, or is castration the answer to their problem? I think not. Better that there be BLACK-GRAYS or GRAY-BLACKS than there be 43 frustrated BLACK could-be libertine cat kins, kousinable kousins, to beautify the world. Skat, kats!
STRONTIUM-89 (SR-89) DOES NOT ADD TO THE TOXICITY OF ADRIAMYCIN IN THE TREATMENT OF PATIENTS WITH ANDROGEN INDEPENDENT (AI) PROSTATE CARCINOMA
Authors: DA Podoloff, ES Delpassand, S. Tu, T Jones, R Amato, J Ellerhorst, R Kilborne, WF Broussard, C. Logothetis
Journal: Clinical Nuclear Medicine (1996)

Podoloff, DA; Delpassand, ES; Tu, S.; Jones, T; Amato, R; Ellerhorst, J; Kilborne, R; Broussard, WF; Logothetis, C. U.T. M.D. Author Information
Specific Features of Non-small Cell Lung Cancer in Women: A Retrospective Study of 1738 Cases Diagnosed in Bas-Rhin between 1982 and 1997
Authors: Jacinthe Foeglé, Guy Hédelin, Marie-Paule Lebitasy, Ashok Purohit, Michel Velten, Elisabeth Quoix
Journal: Journal of Thoracic Oncology (2007)