tbuckley/cabot-search huggingface dataset:
Vinblastine Therapy for Kaposi's Sarcoma in the Acquired Immunodeficiency Syndrome
Authors: PAUL A. VOLBERDING
Journal: Annals of Internal Medicine (1985)

Single-agent intravenous vinblastine, 4 to 8 mg/week, was used to treat 38 patients with Kaposi's sarcoma related to the acquired immunodeficiency syndrome. The dose was titrated in relation to the total leukocyte count. Ten patients had an objective response, and 19 had stable disease during therapy. Apart from expected modest neutropenia, toxicity was minimal. A lower response rate was seen in patients with anemia, an elevated erythrocyte sedimentation rate, or any lymphoma-like B symptom. Opportunistic infections were common regardless of type of response but were commoner in patients who did not respond. Vinblastine used in low doses weekly is effective in treating Kaposi's sarcoma related to the acquired immunodeficiency syndrome and has minimal associated toxicities.
414 Alcohol treatment has a positive effect replication and protein expression and this effect is modulated by 5′-UTR region
Authors: K.C. Trujillo-Murillo, L. Garza-Rodríguez, H. Martínez-Rodríguez, H. Barrera-Saldava, J. Ramos-Jiménez, A.M. Rivas-Estilla
Journal: Journal of Hepatology (2006)
Predictors of progression from normoalbuminuria to microalbuminuria in NIDDM.
Authors: C M Forsblom, P H Groop, A Ekstrand, K J Tötterman, T Sane, C Saloranta, L Groop
Journal: Diabetes Care (1998)

OBJECTIVE: Our objective was to establish the clinical, genetic, metabolic, and immunologic risk factors for the progression of the albumin excretion rate (AER) in normoalbuminuric NIDDM patients. RESEARCH DESIGN AND METHODS: We recruited 108 NIDDM patients with normal AER after a diabetes duration of 9 years to participate in a prospective 9-year follow-up. In addition to conventional clinical and metabolic variables, we assessed microvascular (retinopathy, nephropathy, neuropathy) and macrovascular (coronary heart disease, peripheral vascular disease) diabetic complications, genetic markers (HLA genotypes), and organ-specific autoimmune markers, including islet cell antibodies. Multiple logistic regression was used to determine independent predictors of progression of AER. RESULTS: A total of 21 patients (19%) died during the follow-up. There was an overrepresentation of men (61 vs. 39%; P = 0.044) and smokers (55 vs. 27%; P = 0.01) in patients who progressed to micro- or macroalbuminuria versus those who did not progress. In addition, progressors had higher fasting plasma glucose (P = 0.002) and HbA1 (P = 0.0002) concentrations at baseline than did nonprogressors. Neuropathy was more often seen in progressors than in nonprogressors at baseline (53 vs. 16%; P = 0.0004). Frequency of HLA genotypes and autoimmune markers did not differ between progressors and nonprogressors. In a multiple logistic regression analysis, HbA1 (P = 0.0005) and a history of smoking (P = 0.011) were independent predictors of progression of AER. CONCLUSIONS: This study reemphasizes the importance of poor glycemic control and smoking as independent risk factors for progression of AER. Furthermore, development of micro- or macroalbuminuria in NIDDM was associated with neuropathy and male sex.
Intraclonal diversification of immunoglobulin light chains in a subset of chronic lymphocytic leukemia alludes to antigen-driven clonal evolution
Authors: E Kostareli, L-A Sutton, A Hadzidimitriou, N Darzentas, A Kouvatsi, A Tsaftaris, A Anagnostopoulos, R Rosenquist, K Stamatopoulos
Journal: Leukemia (2010)
Multiple Pacinian neurofibroma and relationship with the finger-tip arterio-venous anastomoses
Authors: L. LEVI, S. B. CURRI
Journal: British Journal of Dermatology (1980)

Journal Article Multiple Pacinian neurofibroma and relationship with the finger‐tip arterio‐venous anastomoses Get access L. LEVI, L. LEVI Dermatological Division, Hospital S. Gerardo dei Tintori, Monza, and Center of Molecular Biology, Milan, Italy Prof. Luciano Levi, Piazzale Maciachini, 10 Milano, Italy. Search for other works by this author on: Oxford Academic Google Scholar S. B. CURRI S. B. CURRI Dermatological Division, Hospital S. Gerardo dei Tintori, Monza, and Center of Molecular Biology, Milan, Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 102, Issue 3, 1 March 1980, Pages 345–349, https://doi.org/10.1111/j.1365-2133.1980.tb08152.x Published: 01 March 1980
Left Atrial Appendage Closure for Atrial Fibrillation
Authors: Claudia Stöllberger, Birke Schneider
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lessons from an audit of unplanned pregnancies.
Authors: D. Metson
Journal: BMJ (1988)

To determine the effectiveness of contraceptive use a two year audit of pregnant women registered in one group practice was carried out. The methods of contraception used by women with unplanned pregnancies were studied and the rates of failure assessed. Of the 518 pregnancies during the study, 187 (36%) were unplanned. Unplanned pregnancies were most common in the 15-19 age group (54 out of 187), and women aged under 25 used contraceptives less reliably than women aged 25 and over. The combined pill was the most effective method of contraception in all age groups. The methods that resulted in most unplanned pregnancies were the sheath in women aged 25 and over and incorrect use of oral contraceptive or no contraception in those aged under 25. The fear of side effects was an important reason why women did not use the combined pill, being cited by 22 out of 134 women, and inappropriate medical advice was cited by a further 20 women. More discussion between doctors and patients and readily available information on the use of oral contraceptives might help to reduce the number of unplanned pregnancies.
Nondissection of Pelvic Lymph Nodes Does Not Influence the Results of Perineal Radical Prostatectomy in Selected Patients
Authors: L. Salomon, A. Hoznek, M.A. Lefr&egrave;re-Belda, J. Bellot, D.K. Chopin, C.C. Abbou
Journal: European Urology (2000)
Suppression of endothelin-1-induced mitogenic responses of human aortic smooth muscle cells by interleukin-1 beta.
Authors: Y Fujitani, H Ninomiya, T Okada, Y Urade, T Masaki
Journal: Journal of Clinical Investigation (1995)

When applied to quiescent human aortic smooth muscle cells (AOSMC), endothelin-1 (ET-1) caused significant increases in mitogen-activated protein kinase (MAPK) activity, [3H]thymidine incorporation, and cell proliferation, confirming an activity of ET-1 as a potent mitogen on AOSMC. As an in vitro model to evaluate the significance of the mitogenic activity of ET-1 on smooth muscle cells during atherogenesis, we studied possible modulations of the responsiveness of the cells by treatment with various cytokines (IL-1 beta, IL-8, TNF alpha, and TGF beta). Of the four cytokines tested, we found that the treatment of the cells with IL-1 beta dramatically reduced the responsiveness of the cells to ET-1; IL-1 beta treatment at the concentration of 0.2 ng/ml for 8 h completely abolished the activity of ET-1 to induce the mitogenic responses. IL-1 beta treatment caused no changes in the responses induced by EGF, basic fibroblast growth factor, or PDGF. Studies on ET-1-induced intracellular signaling events in IL-1 beta-treated cells revealed that the failure of ET-1 to induce mitogenic responses was due to an increase in cAMP formation secondary to ET-1-induced activation of prostanoid metabolism. These findings on AOSMC in vitro raise the possibility that, under some inflammatory conditions in vivo, ETs may work as a negative modulator of smooth muscle cell proliferation.
Peroxynitrite like Pan?
Authors: N PAOLOCCI
Journal: Cardiovascular Research (2005)

Journal Article Peroxynitrite like Pan? Get access Nazareno Paolocci Nazareno Paolocci * Division of Cardiology, Johns Hopkins Hospital, Baltimore, MD, USA *835 Ross Bldg, 720 Rutland Avenue, Baltimore, MD 21205, USA. Tel.: +1 1 410 955 4813; fax: +1 1 410 502 2558. Email address: [email protected] Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 67, Issue 2, August 2005, Pages 176–178, https://doi.org/10.1016/j.cardiores.2005.05.030 Published: 01 August 2005 Article history Received: 24 May 2005 Accepted: 31 May 2005 Published: 01 August 2005
INCREASED MYOCARDIAL VIABILITY AND FUNCTION MEASURED BY MANGANESE-ENHANCED MRI (MEMRI) DEMONSTRATE MYOCARDIAL REGENERATION BY HUMAN PLURIPOTENT STEM CELL DERIVED CARDIOMYOCYTES (HPCMS)
Authors: Atsushi Tachibana, Eric Rulifson, Yuka Matsuura, Rahul Thakker, Mouer Wang, Joseph Wu, Rajesh Dash, Phillip Yang
Journal: Journal of the American College of Cardiology (2015)
Vancomycin-Resistant Staphylococcus aureus
Authors: Kwan Kew Lai
Journal: Annals of Internal Medicine (1996)

Letters15 November 1996Vancomycin-Resistant Staphylococcus aureusKwan Kew Lai, MDKwan Kew Lai, MDUniversity of Massachusetts Medical Center, Worcester, MA 01655-0238.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-10-199611150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Edmond and colleagues [1] gave their perspectives on the measures necessary to control transmission of vancomycin-resistant S. aureus. Most of the measures they suggest are not new and are similar to measures recommended by the Hospital Infection Control Practices Advisory Committee for preventing the spread of vancomycin-resistant enterococci [2]. However, they did suggest some measures that are unique and may be difficult to follow. They stated that a monitor could be placed at the door of a patient infected or colonized with vancomycin-resistant S. aureus. This monitor would prevent unauthorized access and enforce hand washing and barrier ...References1. Edmond MB, Wenzel RP, Pasculle AW. Vancomycin-resistant Staphylococcus aureus: perspectives on measures needed for control. Ann Intern Med. 1996; 124:329-34. Google Scholar2. Recommendations for preventing the spread of vancomycin resistance. Hospital Infection Control Practices Advisory Committee. Infect Control Hosp Epidemiol. 1995; 16:105-13. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Massachusetts Medical Center, Worcester, MA 01655-0238. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1996Volume 125, Issue 10Page: 859KeywordsAbscessesAntimicrobialsEbola virusEnterococcus infectionsHealth care providersInfectious diseasesStaphylococcus aureus Issue Published: 15 November 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Medical Education: Point, Counterpoint
Authors: Henry T. Ricketts
Journal: JAMA (1974)

The pendulum was a great invention, especially for clocks. Its swinging weight measured minutes and hours, and its movement to the right was as certain as doom to be followed by its return to the left. Small wonder, then, that the familiar coming and going and coming again of politics, dress styles, hairdos, customs, and concepts came to be spoken of as pendular. The timepiece itself has made its own contribution to the language. If one doesn't like what seems to be an outdated swing to the past, one calls it "setting the clock back." These kinds of deja vu occur in medical education, as Samuel Z. Goldhaber<sup>1</sup>proves in the Sept 14, 1973, issue of<i>Science</i>. The author, a former intern writer for that journal and now a medical student, has observed a sort of anachronistic turnabout at the Harvard Medical School. There, a few years ago, the
Mortality in Type 1 Diabetes in the Current Era
Authors: Michelle Katz, Lori Laffel
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence of carcinoma in situ of the testis in 207 oligozoospermic men from infertile couples: prospective study of testicular biopsies
Authors: A. Giwercman, J. K. Thomsen, J. Hertz, V. Jensen, N. E Skakkebak, B. Meinecke, J. G Berthelsen, L. Thormann, H. H Storm
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objective:</b> To investigate the prevalence of carcinoma in situ of the testis in a group of oligozoospermic men from infertile couples. <b>Design:</b> A consecutive group of oligozoospermic men from infertile couples were offered bilateral testicular biopsy. The observed prevalence of carcinoma in situ was compared with the expected prevalence of testicular cancer in a corresponding age matched population of Danish men, assuming all untreated cases of carcinoma in situ progress to tumour stage. This calculation was based on data from the Danish Cancer Registry. <b>Subjects:</b> 207 men aged 18–50 years who had sperm density below 10 million/ml in two samples within the previous 2 years or sperm density below 20 million/ml in two samples within the previous 2 years and a history of cryptorchidism or one or two atrophic testicles (orchidometer volume less than 15 cm<sup>3</sup>), or both. <b>Interventions:</b> Bilateral testicular biopsies. <b>Main outcome measures:</b> Carcinoma in situ in the biopsy specimen. <b>Results:</b> No case of carcinoma in situ was found among the 207 men. The expected number in a normal age matched population of corresponding size was 0.8. <b>Conclusion:</b> There is no increase in risk of carcinoma in situ of the testis in moderately oligozoospermic men of couples referred because of infertility. <h3>Key messages</h3> Testicular cancer can be prevented if it is diagnosed at the preinvasive stage of carcinoma in situ Infertile men with atrophic testes were considered as a potential high risk group for testicular neoplasia A prospective study of 207 men from infertile couples did not show any increase in risk of carcinoma in situ of the testis in men with moderate oligozoospermia A high risk of testicular neoplasia in men with very low sperm counts, atrophic testes, and irregular echo pattern on ultrasonography cannot be ruled out
Handbook of Psychiatry for Primary Care
Authors: B. Clair Eliason
Journal: Annals of Internal Medicine (1998)

Medical Writings1 August 1998Handbook of Psychiatry for Primary CareB. Clair Eliason, MDB. Clair Eliason, MDMedical College of Wisconsin, Milwaukee, WisconsinSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-3-199808010-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Handbook of Psychiatry for Primary Care; Allwood CW, Gagiano CA; eds. 326 pages. New York: Oxford Univ Pr; 1997. $29.95. ISBN 0195711823. Order phone 800-451-7556.Field of medicine: Primary care and internal medicine.Format: Softcover book.Audience: Physicians and nurses who treat patients with mental problems.Purpose: To provide practical answers to common problems in a convenient handbook that can be used in conjunction with a standard psychiatry textbook.Content: This book consists of 38 short chapters written by 30 academic psychiatrists from South Africa. There are no illustrations, but several practical algorithms and tables are included. Chapters address such ... Author, Article, and Disclosure InformationAffiliations: Medical College of Wisconsin, Milwaukee, Wisconsin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1998Volume 129, Issue 3Page: 259KeywordsDiagnostic and Statistical Manual of Mental Disorders fourth editionDrug therapyDrugsElderlyEpilepsyHealth care providersPrimary carePsychiatry and mental healthSleep disordersSubstance abuse ePublished: 15 August 2000 Issue Published: 1 August 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effects of oral L-arginine on endothelium-dependent vasodilation and markers of inflammation in healthy postmenopausal women
Authors: Arnon Blum, Londa Hathaway, Rita Mincemoyer, William H Schenke, Martha Kirby, Gyorgy Csako, Myron A Waclawiw, Julio A Panza, Richard O Cannon
Journal: Journal of the American College of Cardiology (2000)
A Different Concept in the Application of Dacryoscintigraphy
Authors: SABRI ZİNCİRKESER, Y. ZEKI ÇELEN
Journal: Clinical Nuclear Medicine (2001)

Purpose Current dacryoscintigraphy methods have several potential pitfalls, the most important of which is the outflow of tears. Another is the difficulty in fixing the head with the patient seated. To overcome these difficulties, a new method was applied. Materials and Methods The study included 77 persons: 43 controls and 34 patients with epiphora. Two methods were applied to the two groups. In the first, protocol 1 (the current conventional protocol), the patient was seated in front of a gamma camera and one drop (50 μl) Tc-99m pertechnetate containing 50 to 100 μCi radioactivity was instilled in the inferior fornix or outer canthus of the eye and dynamic and static images were obtained for approximately 15 to 20 minutes. In the other, protocol 2 (our protocol), 100 μCi (10 μl) Tc-99m pertechnetate was instilled in the outer canthus of the eye using a micropipette with the patient in the supine position under the gamma camera. Dynamic images were taken for only 5 minutes. Conclusion The pitfalls and difficulties seen with protocol 1 were lessened to a great degree in protocol 2.
Computerized Tomography and Radionuclide Scanning in Hepatic Disease: A Retrospective Study
Authors: MARTIN L. FRIEDMAN, FRANCES L. ESPOSITO, BERNARD J. OSTRUM, ROBERT E. CANTOR, BRUCE P. SHERMAN
Journal: Clinical Nuclear Medicine (1978)

This was a retrospective study of 117 patients, who had both computerized tomography (CT) and nuclear scans of the liver. In the evaluation of hepatic masses, the nuclear and CT scans, demonstrated 83% and 77% of the masses, respectively, in combination they demonstrated 97%. The nuclear scan proved to be a more sensitive procedure for demonstrating the presence of intrahepatic pathology. The CT scans were better able to demonstrate specific disease entities, such as biliary obstruction and fatty infiltration of the liver. CT was also able to evaluate adjacent organs. When used in combination, CT and nuclear scans tended to complement each other and in many cases were helpful in arriving at a more specific diagnosis.
Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children
Authors: Sarah H. Atkinson, Andrew E. Armitage, Shivani Khandwala, Tabitha W. Mwangi, Sophie Uyoga, Philip A. Bejon, Thomas N. Williams, Andrew M. Prentice, Hal Drakesmith
Journal: Blood (2014)
The Diagnosis and Treatment of Depression in the Old-Reply
Authors: Seymour L. Kushnir
Journal: JAMA (1988)

<h3>In Reply.—</h3> I disagree with Dr. Fink. In geriatric psychiatry, where diagnosis can be uncertain, as when distinguishing depression from dementia, response to treatment is an important diagnostic tool. Used in this context, psychopharmacology offers more flexibility and practicality than does electroconvulsive therapy (ECT). Would it not be a disservice to treat with ECT a cognitively impaired 102-year-old woman with no prior history of depression when only 5% to 10% of elderly patients with cognitive impairment have pseudodementia?<sup>1</sup>Moreover, a depressive syndrome can be the presenting feature of degenerative brain pathology, eg, Alzheimer's disease, multi-infarct dementia, and parkinsonian dementia.<sup>2</sup>Under such circumstances would it not seem more reasonable to pick up functional depression from a positive response to carefully controlled drug therapy than to confirm dementia from a negative response to ECT? The flexibility of psychopharmacological strategies derives from a range of antidepressants that are serotonergic or noradrenergic,
Effects of High-Intensity Strength Training on Multiple Risk Factors for Osteoporotic Fractures
Authors: Miriam E. Nelson
Journal: JAMA (1994)

To determine how multiple risk factors for osteoporotic fractures could be modified by high-intensity strength training exercises in postmenopausal women.Randomized controlled trial of 1-year duration.Exercise laboratory at Tufts University, Boston, Mass.Forty postmenopausal white women, 50 to 70 years of age, participated in the study; 39 women completed the study. The subjects were sedentary and estrogen-deplete.High-intensity strength training exercises 2 days per week using five different exercises (n = 20) vs untreated controls (n = 19).Dual energy x-ray absorptiometry for bone status, one repetition maximum for muscle strength, 24-hour urinary creatinine for muscle mass, and backward tandem walk for dynamic balance.Femoral neck bone mineral density and lumbar spine bone mineral density increased by 0.005 +/- 0.039 g/cm2 (0.9% +/- 4.5%) (mean +/- SD) and 0.009 +/- 0.033 g/cm2 (1.0% +/- 3.6%), respectively, in the strength-trained women and decreased by -0.022 +/- 0.035 g/cm2 (-2.5% +/- 3.8%) and -0.019 +/- 0.035 g/cm2 (-1.8% +/- 3.5%), respectively, in the controls (P = .02 and .04). Total body bone mineral content was preserved in the strength-trained women (+2.0 +/- 68 g; 0.0% +/- 3.0%) and tended to decrease in the controls (-33+77 g; -1.2% +/- 3.4%, P = .12). Muscle mass, muscle strength, and dynamic balance increased in the strength-trained women and decreased in the controls (P = .03 to < .001).High-intensity strength training exercises are an effective and feasible means to preserve bone density while improving muscle mass, strength, and balance in postmenopausal women.