tbuckley/cabot-search huggingface dataset:
TCT-520 Long-Term CT-Scan Follow-up Of Inferior Vena Cava Filter: Warning Bells From A Single-Center Experience
Authors: Paolo M. Ravagnani, Piero Montorsi, Stefano Galli, Giovanni Ballerini, Gianluca Pontone, Erika Bertella, Daniela Trabattoni, Franco Fabbiocchi, Alessandro Lualdi, Antonio L. Bartorelli
Journal: Journal of the American College of Cardiology (2013)
Cadmium Exposure and Hypertension in the 1999–2004 National Health and Nutrition Examination Survey (NHANES)
Authors: Maria Tellez-Plaza, Ana Navas-Acien, Ciprian M. Crainiceanu, Eliseo Guallar
Journal: Environmental Health Perspectives (2007)

Cadmium induces hypertension in animal models. Epidemiologic studies of cadmium exposure and hypertension, however, have been inconsistent.We aimed to investigate the association of blood and urine cadmium with blood pressure levels and with the prevalence of hypertension in U.S. adults who participated in the 1999-2004 National Health and Nutrition Examination Survey (NHANES).We studied participants > or = 20 years of age with determinations of cadmium in blood (n = 10,991) and urine (n = 3,496). Blood and urine cadmium were measured by atomic absorption spectrometry and inductively coupled plasma-mass spectrometry, respectively. Systolic and diastolic blood pressure levels were measured using a standardized protocol.The geometric means of blood and urine cadmium were 3.77 nmol/L and 2.46 nmol/L, respectively. After multivariable adjustment, the average differences in systolic and diastolic blood pressure comparing participants in the 90th vs. 10th percentile of the blood cadmium distribution were 1.36 mmHg [95% confidence interval (CI), -0.28 to 3.00] and 1.68 mmHg (95% CI, 0.57-2.78), respectively. The corresponding differences were 2.35 mmHg and 3.27 mmHg among never smokers, 1.69 mmHg and 1.55 mmHg among former smokers, and 0.02 mmHg and 0.69 mmHg among current smokers. No association was observed for urine cadmium with blood pressure levels, or for blood and urine cadmium with the prevalence of hypertension.Cadmium levels in blood, but not in urine, were associated with a modest elevation in blood pressure levels. The association was stronger among never smokers, intermediate among former smokers, and small or null among current smokers. Our findings add to the concern of renal and cardiovascular cadmium toxicity at chronic low levels of exposure in the general population.
SCURVY FOLLOWING A RESTRICTED DIET IN COLITIS
Authors: Samuel L. Immerman
Journal: JAMA (1930)

Mrs. M. R., aged 42, seen, Feb. 4, 1929, had become ill in September, 1928, the illness starting with slight nausea in the morning, followed later by distress on each side of the epigastrium and a lump in the throat, chiefly after eating fried scrapple. The distress consisted of little pains, not of a pressing character. These symptoms persisted for a period of two months, when the patient noticed a partly formed and partly watery bowel movement, with mucus, attributed to the eating of pumpkin pie. The diarrhea lasted two days; it returned shortly with pain in the right side and around the umbilicus; this attack lasted two days. There was then a tendency to diarrhea with food particles in the bowel movement. By January, 1929, the bowel movement was of a mushy character. Up to this time the patient was on her usual diet, but for a short time
False-Positive Results for Hepatic Hemangioma on Tc-99m RBC SPECT Caused by a Liver Metastasis From Small-Cell Lung Carcinoma
Authors: WEI-JEN SHIH, JONG-KANG LEE, BONNIE MITCHELL
Journal: Clinical Nuclear Medicine (1996)

Tc-99m RBC liver imaging has been used to confirm hemangiomas on inconclusive US and CT studies. A hot spot on the Tc-99m RBC blood pool imaging is characteristic of a hemangioma. A patient with a suspected hemangioma on US whose Tc-99m RBC showed a hot area was found to be a metastatic lesion from a small-cell carcinoma of the right lung.
Ritodrine-induced acidosis in pregnancy.
Authors: D Desir, A Van Coevorden, C Kirkpatrick, A Caufriez
Journal: BMJ (1978)

Beta-sympathomimetic agents such as salbutamol, terbutaline, and ritodrine are commonly used to prevent premature delivery but may have metabolic side effects, particularly in the case of salbutamol. Enhanced lipolysis and glycolysis result in raised blood glucose, fatty acid, and lactate concentrations and a fall in serum bicarbonate. Severe metabolic acidosis, however, has been described only in pregnancy complicated by diabetes. A case of decompensated acidosis that occurred during an infusion of ritodrine is reported.
A PROSPECTIVE RANDOMIZED STUDY USING OPTICAL COHERENCE TOMOGRAPHY TO ASSESS ENDOTHELIAL COVERAGE AND NEOINTIMAL PROLIFERATION AT 6 MONTHS AFTER IMPLANTATION OF A CORONARY EVEROLIMUS-ELUTING STENT COMPARED WITH A BARE METAL STENT POSTDILATED WITH A PACLITAXEL-ELUTING BALLOON (OCTOPUS TRIAL)
Authors: Tudor C. Poerner, Sylvia Otto, Florian Janiak, Johannes Gassdorf, Hans R. Figulla
Journal: Journal of the American College of Cardiology (2012)
The cell cycle in psoriasis
Authors: PETER GOODWIN, SUSAN HAMILTON, LIONEL FRY
Journal: British Journal of Dermatology (1974)

Journal Article The cell cycle in psoriasis Get access PETER GOODWIN, PETER GOODWIN Department of Dermatology, St Mary's Hospital, London, W.2 Search for other works by this author on: Oxford Academic Google Scholar SUSAN HAMILTON, SUSAN HAMILTON Department of Dermatology, St Mary's Hospital, London, W.2 Search for other works by this author on: Oxford Academic Google Scholar LIONEL FRY LIONEL FRY Department of Dermatology, St Mary's Hospital, London, W.2 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 90, Issue 5, 1 May 1974, Pages 517–524, https://doi.org/10.1111/j.1365-2133.1974.tb06446.x Published: 01 May 1974 Article history Accepted: 13 August 1973 Published: 01 May 1974
RESEARCH ON VITAMINS AND HORMONES
Authors: W. A. Peabody
Journal: JAMA (1933)

To the Editor:  —I chanced to read the report by your Berlin correspondent entitled Research on Vitamins and Hormones (The Journal, September 9, p. 867) shortly after having consulted the original paper by Kuhn and collaborators ( Ber. d. Deutsche Chem. Gesellsch.  66 B , 1034). Kuhn gave evidence that the antipellagra factor is not identical with the lyochromes and referred to the work of P. Gyorgy who designated the antipellagra factor  H.  Further, since evidence has been accumulating in recent years that the vitamin B complex contains two or more factors in addition to B 1 , it may not be entirely correct to hold that  further, colorless factor derived from  (complementary to the lyochromes) was previously unknown. Whether  H is a component of this particular yeast fraction is not clear, since Gyorgy's report is not yet available to me. However, Kuhn pointed out that purified  H
Detecting and managing hypertension.
Authors: B S Smith
Journal: BMJ (1979)

<h3>Background</h3> With survival rates for preterm infants improving constantly, more emphasis is being placed on optimising nutrition. Suboptimal nutrition in the early neonatal period contributes significantly to postnatal malnutrition and accumulation of growth deficits. Delaying the introduction of enteral nutrition can result in reduced resistance to infection. <h3>Aim</h3> To analyse the feeding practice in less than 30 weeks gestation babies in a tertiary neonatal centre. <h3>Methods</h3> Retrospective analysis of data from July to December 2012. Data was collected from electronic patient management system (Badger) and patient notes. <h3>Results</h3> 18/34 babies case notes were identified and analysed.15 were extreme preterm babies (&lt;28 weeks) and 5 were more than 28 weeks. Average weight was 854 grams (range: 538–1266 grams). In first 2 weeks of life EBM was used in 16 babies and formula was used in one and feed was not started in one. Feeds were started between 2 to 8 days of life in 17 babies and on average on day 5 of life, 6 babies were fully fed by 14 days of life (range: 10–14 days). At the time of discharge from hospital 6 babies were on breast milk, 4 babies on mixed feeds, 7 babies on formula milk, and 1 baby died. <h3>Conclusion</h3> Our unit is EBM friendly unit with 16 out of the 18 eligible babies were given EBM. But there was no EBM available from 48 h of birth as recommended by the toolkit. More education and awareness is planned to improve this.
Effect of High-Dose Amoxicillin on the Prevalence of Penicillin-Resistant Streptococcus pneumoniae in Rural Alaska
Authors: T. W. Hennessy
Journal: JAMA (2002)

To the Editor: Drs Wachter and Goldman1 acknowledge that the growth of the hospitalist movement may result in more discontinuity of care. In addition, physicians may lose some of their clinical skills after prolonged absence from the hospital setting.
Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone
Authors: CL Leach, PJ Davidson, RJ Boudreau
Journal: European Respiratory Journal (1998)

Hydrofluoroalkane-134a (HFA) beclomethasone dipropionate (BDP) was formulated in a metered-dose inhaler (MDI) to deliver a particle size of 1.1 microm compared with 35 microns for currently marketed chlorofluorocarbon (CFC)-BDP products. Two phase I single-dose human deposition studies were conducted using technetium 99m-radiolabelled BDP in a press-and-breathe actuator without an add-on spacer. A healthy volunteer study (n=6) showed that 55-60% of the HFA-BDP ex-actuator dose was deposited in the lungs, with 29-30% deposited in the oropharynx. CFC-BDP deposition was 4-7% in the lungs and 90-94% in the oropharynx. The pattern of deposition within the lung showed that HFA-BDP was spread diffusely throughout the lung airways, whereas CFC-BDP was confined to the central airways with little, if any, peripheral airway deposition. A second study with asthmatics (n=16) confirmed that 56% of the HFA-BDP dose was deposited in the airways, with 33% in the oropharynx. In conclusion, hydrofluoroalkane-134a-beclomethasone dipropionate deposition was much greater in the airways than chlorofluorocarbon-beclomethasone dipropionate, with a concomitant reduction in oropharyngeal deposition. The increased lung deposition efficiency of the hydrofluoroalkane propellant has led to a reduction in the amount of beclomethasone dipropionate needed to achieve a similar efficacy. The penetration of the hydrofluoroalkane to the small airways may provide asthma treatment not afforded by conventional chlorofluorocarbons.
Clinical Lecture on Cirrhosis of the Liver
Authors: R. Saundby
Journal: BMJ (1886)

seruw *d umrine-can then readily eiscape, a*nd the risk of infiltr&- tion '1 urine is reduceed to a iiininidm.A gbod-sizeid rubb6, or silk-e606stf6' utbc may be used to facilitate dainage for-two or three dlji.FI' have miade this tube of stfficient lerigth,' tb' reach into & ba:i 'pl'aced b3 tbe bedside, and haVe fastened it to -ne'edge of the out0.wnd to prevent it 'being accidetitally d&aggeO out; by this meaus the, patient is kept Dbmparatively dry iandrcoxfortable ; he lies fif#t pni o014b side, and then on the other, the 'nute carefully carrying thiN%tibe from side to side with him.There are two' Iilads 44reotal bai gn tise: one, a simple pear-shaped rubber bottle, which will dilate to ioy 'ie;'the 'other has a layer of linen in its wills, and Willos oty hdil l'&ertaih quantity; the former, when enmpty end 'tolled up, {s rat 'ji the easier to introduce, but it should be filled from a gra- dd te&'glass vessel so that the exact quantity desifed, say twelve or fo irien oiincs, may be introduced, 'These, and other details of' the opes'tion; however, may come to b~modified as experiewee iireases.Ii fnales, in whose bladder a full quantity of water cannot eabily he'tbtiined`, Sir H. Thompson has recohim6nded the use of a hollotv soOidq With a slit at the end, fitted by a stylet * this is made to push aNl ttie front wall of the bladder, close 'behind the pubeA, where it at YEld inthe wound ; the stylet is withdtswn, the slit' is struck by t sca)pel, and the bladder 'opened.It is'doubtflf whether this mnsecei,Vbe will, in practice, be found edessdray.have ftmnd that, in tb6 'dead 'body, the pressure upwards of the recfal bag is suf- ficiont to close the vesical orifice, and retain a fair quantity of fluid in"'hlie blidder; or the finger of an assistant, pressing' the ux)thra a'iit" tl,e"pubic arch, would readily etai the wat.er until the bl4dder is opened from above.' 't"Wchildren, even then the bladder 'and 'ectum are empty, 'the pe!lionael fold is generally from half an inch to an inch above the pUiis'; but, with a distended, 1Iladder, with three or four ounces 06n, it will be carried well up out of harm's way.No distension' of,rectum is required, but the' fingyer of anl assistant may be of use in helping to raise the stone and the floor of the bladder..7.
Vitamin C and Growth
Authors: Thomas H. Jukes
Journal: JAMA (1977)

To the Editor. —  Miller and co-workers (237:248, 1977) claim to have observed an effect of vitamin C on growth in young male  Inspection of their data (Table 1) indicates that such a conclusion is unjustified.  Their conclusion was drawn solely from the comparison with placebo for 500 mg/day. An opposite conclusion could just as easily (and equally erroneously) be drawn from the figures for 1,000 mg/day for male twins. Actually, three sets grew more rapidly with vitamin C, and three more rapidly with placebo. Finally, when the total growths for both sexes are summarized, 42 vitamin C twins grew a total of 129.60 cm for an average of 3.09 cm, and 42 placebo twins grew 131.69 cm for an average of 3.14 cm. In short, growth on vitamin C was slightly, but obviously insignificantly, less than growth on placebo. In any experiment on growth rates conducted with experimental
TCT-662 One Year Outcomes Following PCI in Patients with Asymptomatic CAD: A Report from the NHLBI Dynamic Registry
Authors: Mohun Ramratnam, Faith Selzer, Dustin Kliner, Catalin Toma, Sameer Khandhar, Sherry Kelsey, David Williams, Oscar Marroquin, Suresh Mulukutla
Journal: Journal of the American College of Cardiology (2012)
Scientific and Regulatory Reasons for Delay and Denial of FDA Approval of Initial Applications for New Drugs, 2000-2012
Authors: Leonard V. Sacks, Hala H. Shamsuddin, Yuliya I. Yasinskaya, Khaled Bouri, Michael L. Lanthier, Rachel E. Sherman
Journal: JAMA (2014)

Some new drug applications fail because of inadequate drug performance and others are not approved because the information submitted to the US Food and Drug Administration (FDA) is unsatisfactory to make that determination.Resubmission of failed applications is costly, delaying marketing approval and the availability of new drugs to patients.OBJECTIVE To identify the reasons that FDA marketing approval for new drugs was delayed or denied. DESIGN, SETTING, AND PARTICIPANTSA retrospective review of FDA documents and extraction of data were performed.We examined all drug applications first submitted to the FDA between 2000 and 2012 for new molecular entities (NMEs), which are active ingredients never before marketed in the United States in any form.Using FDA correspondence and reviews, we investigated the reasons NMEs failed to obtain FDA approval. MAIN OUTCOMES AND MEASURESReasons for delayed FDA approval or nonapproval of NME applications. RESULTSOf the 302 identified NME applications, 151 (50%) were approved when first submitted and 222 (73.5%) were ultimately approved.Seventy-one applications required 1 or more resubmissions before approval, with a median delay to approval of 435 days following the first unsuccessful submission.Of the unsuccessful first-time applications, 24 (15.9%)included uncertainties related to dose selection, 20 (13.2%) choice of study end points that failed to adequately reflect a clinically meaningful effect, 20 (13.2%) inconsistent results when different end points were tested, 17 (11.3%)inconsistent results when different trials or study sites were compared, and 20 (13.2%) poor efficacy when compared with the standard of care.The frequency of safety deficiencies was similar among never-approved drugs compared with those with delayed approval (43 of 80 never approved [53.8%] vs 37 of 71 eventually approved [52.1%]; difference, 1.7% [95% CI, -14.86% to 18.05%]; P = .87).However, efficacy deficiencies were significantly more frequent among the never-approved drugs than among those with delayed approvals (61 of 80 never approved [76.3%] vs 28 of 71 eventually approved [39.4%]; difference, 36.9% [95% CI, 20.25% to 50.86%]; P < .001).CONCLUSIONS AND RELEVANCE Several potentially preventable deficiencies, including failure to select optimal drug doses and suitable study end points, accounted for significant delays in the approval of new drugs.Understanding the reasons for previous failures is helpful to improve the efficiency of clinical development for new drugs.
The sequential occurrence of viral mutations in a liver transplant recipient re-infected with hepatitis B: hepatitis B immune globulin escape, famciclovir non-response, followed by lamivudine resistance resulting in graft loss
Authors: Robert A. de Man, Angeline I. Bartholomeusz, Hubert G.M. Niesters, Pieter E. Zondervan, Stephen A. Locarnini
Journal: Journal of Hepatology (1998)
The Burden of Respiratory Syncytial Virus Infection in Young Children
Authors: Caroline Breese Hall, Geoffrey A. Weinberg, Marika K. Iwane, Aaron K. Blumkin, Kathryn M. Edwards, Mary A. Staat, Peggy Auinger, Marie R. Griffin, Katherine A. Poehling, Dean Erdman, Carlos G. Grijalva, Yuwei Zhu, Peter Szilagyi
Journal: New England Journal of Medicine (2009)

The primary role of respiratory syncytial virus (RSV) in causing infant hospitalizations is well recognized, but the total burden of RSV infection among young children remains poorly defined.We conducted prospective, population-based surveillance of acute respiratory infections among children under 5 years of age in three U.S. counties. We enrolled hospitalized children from 2000 through 2004 and children presenting as outpatients in emergency departments and pediatric offices from 2002 through 2004. RSV was detected by culture and reverse-transcriptase polymerase chain reaction. Clinical information was obtained from parents and medical records. We calculated population-based rates of hospitalization associated with RSV infection and estimated the rates of RSV-associated outpatient visits.Among 5067 children enrolled in the study, 919 (18%) had RSV infections. Overall, RSV was associated with 20% of hospitalizations, 18% of emergency department visits, and 15% of office visits for acute respiratory infections from November through April. Average annual hospitalization rates were 17 per 1000 children under 6 months of age and 3 per 1000 children under 5 years of age. Most of the children had no coexisting illnesses. Only prematurity and a young age were independent risk factors for hospitalization. Estimated rates of RSV-associated office visits among children under 5 years of age were three times those in emergency departments. Outpatients had moderately severe RSV-associated illness, but few of the illnesses (3%) were diagnosed as being caused by RSV.RSV infection is associated with substantial morbidity in U.S. children in both inpatient and outpatient settings. Most children with RSV infection were previously healthy, suggesting that control strategies targeting only high-risk children will have a limited effect on the total disease burden of RSV infection.
Improvement of endothelial vasomotor dysfunction by treatment with alpha-tocopherol in patients with high remnant lipoproteins levels
Authors: Kiyotaka Kugiyama, Takeshi Motoyama, Hideki Doi, Hiroaki Kawano, Nobutaka Hirai, Hirofumi Soejima, Yuji Miyao, Keiji Takazoe, Yasushi Moriyama, Yuji Mizuno, Ryusuke Tsunoda, Hisao Ogawa, Tomohiro Sakamoto, Seigo Sugiyama, Hirofumi Yasue
Journal: Journal of the American College of Cardiology (1999)
Enhancement of rabbit cardiac sodium channels by beta-adrenergic stimulation.
Authors: J J Matsuda, H Lee, E F Shibata
Journal: Circulation Research (1992)

Voltage-dependent sodium channels from a variety of tissues are known to be phosphorylated by the cAMP-dependent protein kinase, protein kinase A. However, the functional significance of sodium channel phosphorylation is not clearly understood. Using whole-cell voltage-clamp techniques, we show that sodium currents (INas) in rabbit cardiac myocytes are enhanced by isoproterenol (ISO). This enhancement of INa by ISO 1) is holding potential dependent, 2) can be mimicked by forskolin and dibutyryl cAMP, and 3) is accompanied by an increase in the rate of Na+ channel inactivation. In single-channel, inside-out patch experiments, the catalytic subunit of protein kinase A also enhances INa and increases the rate of inactivation, suggesting that cardiac Na+ channel phosphorylation may be physiologically important. Addition of the protein kinase A inhibitor to the pipette solution in whole-cell experiments blocks the stimulatory effect of forskolin without blocking the effect of ISO, suggesting that ISO also enhances INa through a cAMP-independent pathway. To determine if ISO may stimulate INa through a direct G protein pathway, single channels were recorded in the presence of the Gs-activating GTP analogue, GTP gamma S, and the stimulatory G protein subunit, Gs alpha. Both of these agents enhanced INa without affecting the rate of Na+ channel inactivation. These results suggest that ISO enhances rabbit cardiac INa through a dual (direct and indirect) G protein regulatory pathway.
Jehoiada John Brown
Authors: J. Connell, A. Brown
Journal: BMJ (2009)

Jehoiada John Brown (“Joyda”) was a well known and highly respected physician and clinical scientist, who worked in the Medical Research Council Blood Pressure Unit in the Western Infirmary in Glasgow from 1967 until he retired in 1992. He had a high international reputation for his clinical practice, which was informed by research based observations, and, equally importantly, for the warmth and generousity of his nature.

Joyda was born in Croescyceiliog, South Wales. He was intensely proud of his Welsh heritage and upbringing, and his adult persona reflected the values instilled during his formative years. His father was a cabinet maker and prominent in local government. It was this heritage of craftsmanship and public service, set against a background of Welsh non-conformism, that shaped his character, exemplified by hard work, precision of thought and deed, and a wish to serve others.

He attended West Monmouthshire Grammar School, where he excelled in sport, representing Welsh schools at athletics and rugby. On leaving school he matriculated in medicine at Cardiff University, but his passion for rugby led him to transfer after one year to St Mary’s in London, which, at the time, had a high reputation for prowess in hospital rugby competitions. At St Mary’s he gained a first class degree in physiology and graduated in medicine in 1951. As a student he represented United London Hospitals at rugby, and continued to perform at a high level in athletics. He remained an enthusiastic, if somewhat caustic …