tbuckley/cabot-search huggingface dataset:
Multiple cutaneous immunocytoma with secondary anetoderma: a report of two cases
Authors: F.J. Child, A. Woollons, M.L. Price, E. Calonje, R. Russell-Jones
Journal: British Journal of Dermatology (2000)

Journal Article Multiple cutaneous immunocytoma with secondary anetoderma: a report of two cases Get access F.J. Child, F.J. Child Skin Tumour Unit and Dr Fiona Child. E‐mail: fionachild@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar A. Woollons, A. Woollons Department of Dermatology, Brighton Healthcare NHS Trust, Brighton, U.K. Search for other works by this author on: Oxford Academic Google Scholar M.L. Price, M.L. Price Department of Dermatology, Brighton Healthcare NHS Trust, Brighton, U.K. Search for other works by this author on: Oxford Academic Google Scholar E. Calonje, E. Calonje Department of Dermatopathology, St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, U.K. Search for other works by this author on: Oxford Academic Google Scholar R. Russell‐Jones R. Russell‐Jones Skin Tumour Unit and Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 1, 1 July 2000, Pages 165–170, https://doi.org/10.1046/j.1365-2133.2000.03609.x Published: 01 July 2000
Over a third of trusts in England face financial difficulties
Authors: L. Beecham
Journal: BMJ (1997)

The National Audit Office has said that by the end of the third quarter of 1996-7, 168 of the 433 trusts in England faced financial difficulties, which were serious in 47 cases. This is a rise on 1995-6, when 95 trusts had difficulties, which were serious in 26 cases.

At the same time 36 out of 100 health authorities were forecasting deficits of more than £1m ($1.6m) at the end of 1996-7, compared with 15 at the end of 1995-6.

The reasons for the …
Impact of hepatitis C virus infection on clinical outcome in recipients after allogeneic hematopoietic cell transplantation
Authors: Hideki Nakasone, Saiko Kurosawa, Kimikazu Yakushijin, Shuichi Taniguchi, Makoto Murata, Kazuhiro Ikegame, Takeshi Kobayashi, Tetsuya Eto, Koichi Miyamura, Hisashi Sakamaki, Yasuo Morishima, Tokiko Nagamura, Ritsuro Suzuki, Takahiro Fukuda
Journal: American Journal of Hematology (2013)

The impact of hepatitis C virus (HCV) infection on outcomes following allogeneic hematopoietic cell transplantation (HCT) remains a matter of debate. We have retrospectively examined the significance of HCV infection among recipients who received allogeneic HCT, using a Japan transplant outcome registry database between 2006 and 2009. Among 7,831 recipients, 136 were HCV-positive. The rate of hematopoietic recovery was lower in the HCV-positive group (neutrophil recovery of 500 × 10(6) /L or higher: 79% vs. 87% at Day 30, P = 0.087; platelet recovery of 50 × 10(9) /L or higher: 57% vs. 65% at Day 60, P = 0.012). The HCV-positive group had a significantly higher incidence of nonrelapse mortality 38% vs. 25% at 2 years, P < 0.01) and inferior overall survival (41% vs. 51% at 2 years, P < 0.01). A multivariate analysis revealed that HCV seropositivity was associated with an independent risk for higher nonrelapse mortality (hazard ratio: 1.65, P < 0.01) and inferior overall survival (hazard ratio: 1.39, P < 0.01). The incidences of death due to hepatic problems (8% vs. 2%, P < 0.01), bacterial infection (10% vs. 4%, P < 0.01), or graft failure (5% vs. 2%, P = 0.084) tended to be higher in the HCV-positive group. HCV infection had an adverse impact on the clinical outcome following HCT, especially in the setting of unrelated transplantation. Careful evaluation before embarking on HCT and intensive assessment against complications are warranted in HCV-infected recipients.
Zoster-like Disease in the Newborn Due to Herpes-Simplex Virus
Authors: Stanley I. Music, Eric M. Fine, Yasushi Togo
Journal: New England Journal of Medicine (1971)

CLASSIC herpes zoster (shingles) rarely presents diagnostic or etiologic difficulties in older children or adults. However, no etiology for unilateral grouped vesicular eruptions in the neonate has been established. Since the original report by Lomer1 in 1889, neonatal zoster has been reported 10 other times2 3 4 5 6 7 8 9 10 11; yet in none was the etiology proved by virus isolation. The purpose of the present report is to describe a neonate with a zosteriform eruption due to herpes-simplex virus.Case ReportC.Q. (38–35–80), a 12-day-old Negro girl, was admitted to the University of Maryland Hospital for evaluation of an acute vesicular eruption. The mother, . . .
Non-invasive detection of genomic imbalances in Hodgkin/Reed-Sternberg cells in early and advanced stage Hodgkin's lymphoma by sequencing of circulating cell-free DNA: a technical proof-of-principle study
Authors: Peter Vandenberghe, Iwona Wlodarska, Thomas Tousseyn, Luc Dehaspe, Daan Dierickx, Magali Verheecke, Anne Uyttebroeck, Oliver Bechter, Michel Delforge, Vincent Vandecaveye, Nathalie Brison, Gregor EG Verhoef, Eric Legius, Frederic Amant, Joris R Vermeesch
Journal: The Lancet Haematology (2015)
New technologies in medicine and medical journals
Authors: A. BERGER, R. SMITH
Journal: BMJ (1999)

For most of medicine the future is highly uncertain 

Edwina Clark, a 42 year old woman with diabetes, no longer needs to test her blood sugar concentrations every day because she now has a glucose sensor implanted under the skin of her thigh. Her toilet at home provides a double check because it can analyse glucose, protein, and bacteria concentrations in her urine. Instead of giving herself daily injections of insulin, she now relies on an implanted insulin reservoir that automatically adjusts her insulin dose. Her blood sugar concentrations are so well controlled that she is unlikely ever to develop any of the vascular and neurological complications that used to be common.

The futuristic technology Edwina is using is almost here. Exciting advances and new technologies are appearing every day. We already have computer systems that make diagnoses, and telemedicine is beginning to …
Simultaneous Right Inguinal Hernioplasty and Appendectomy
Authors: George B. Sanders
Journal: JAMA (1964)

CUSTOM and wide experience have put the seal of approval on coincidental appendectomy as a supplement to a variety of abdominal operations such as cholecystectomy, gastrectomy, and hysterectomy. Good surgical judgment, however, demands, among other things, that (1) the appendix be reasonably accessible; (2) no additional risk be incurred by the patient, whose safety may already be jeopardized by the primary surgical condition; (3) No additional incision, or extravagant extension of the primary incision be necessary for safe removal of the appendix; (4) the primary purpose and expected good results of the main operation be not interfered with or diminished, in any way, by the supplementary procedure. Often it is undeniably an advantage to be able to remove the appendix at the time of right inguinal hernioplasty. Recently, papers dealing with this subject have emphasized an approach to the appendix through the neck of the hernial sac.<sup>1,2</sup>In the
Quantitation of intrinsic drug-metabolizing capacity in human liver biopsy specimens: Support for the intact-hepatocyte theory
Authors: Beat Meyer, Hesheng Luo, Mario Bargetzi, Eberhard L. Renner, Georg A. Stalder
Journal: Hepatology (1991)

Hepatic drug metabolism is decreased in patients with severe liver disease, but it is unclear to what extent this is due to altered hepatic blood flow or reduced intrinsic metabolic capacity. In this study we quantitated in needle-biopsy specimens the intrinsic capacity of liver tissue from 67 patients with mild liver disease (n = 36), chronic active hepatitis (n = 16) and cirrhosis (n = 15) to metabolize two model compounds in vitro. Hydroxylation of the low-extraction drug bufuralol resulted in the formation of 251 +/- 25 nmol 1'OH-bufuralol/gm wet wt/hr in mildly diseased liver tissue and was significantly (p less than 0.01) reduced in liver tissue exhibiting chronic active hepatitis (166 +/- 23 nmol/gm wet wt/hr) and cirrhosis (124 +/- 21 nmol/gm wet wt/hr). The formation rates of monoethylglycinexylidide, the main metabolite of the high-extraction drug lidocaine, varied widely and were not significantly different among the three groups. To relate the drug-metabolizing capacity to the hepatocyte content of liver tissue, morphometrical study was performed in the biopsy pieces originally submitted. The metabolic activity of each biopsy piece was then related to the fractional volume of hepatocytes it was calculated to contain. In mildly diseased liver tissue 355 +/- 35 nmol 1'OH-bufuralol/ml hepatocytes x hr or 12.4 +/- 1.0 mumol monoethylglycinexylidide/ml hepatocytes x hr- and in cirrhotic liver tissue 306 +/- 49 nmol 1'OH-bufuralol/ml hepatocytes x hr or 15.3 +/- 3.0 mumol monoethylglycinexylidide/ml hepatocytes x hr--were formed, respectively, and these differences were not significant.(ABSTRACT TRUNCATED AT 250 WORDS)
Pediatric Heart Transplantation in Human Leukocyte Antigen–Sensitized Patients
Authors: Stacey M. Pollock-BarZiv, Neal den Hollander, Bo-Yee Ngan, Paul Kantor, Brian McCrindle, Lori J. West, Anne I. Dipchand
Journal: Circulation (2007)

There is an elevated risk for poor outcomes after heart transplant (HTx) in patients sensitized to human leukocyte antigens including graft dysfunction, acute cellular and antibody-mediated (AMR) rejection, and cardiac allograft vasculopathy. We report our experience with human leukocyte antigens-sensitized pediatric HTx recipients.We identified pediatric HTx patients with elevated pre-HTx Panel Reactive Antibody (Class I/II; > 10%), or a positive T- or B-cell crossmatch. Thirteen patients met criteria (5 female, 39%). The median age at HTx was 7 months (3.5 months to 15.5 years). Nine were infants who had prior palliation for congenital heart disease. Four were older patients (median 7.3 years; 4.8 to 15.5 years): 2 had congenital heart disease (Fontan), 2 were re-HTx. B-cell therapies were used in all patients, guided by assessment of CD19+ and CD20+ cells. Immunosuppression included thymoglobulin induction, and tacrolimus, mycophenolate mofetil, and steroids. Daily plasmapheresis +/- intravenous immunoglobulin G was used if there was a positive crossmatch on day 1, with a gradual, biopsy-guided weaning schedule. Rituximab was used when AMR was detected on biopsy: more recently (n=3), used empirically perioperatively. AMR was confirmed in 9 patients within median 0.9 months post-HTx. Seven had early acute cellular rejection (> or = ISHLT Grade 2 R) with no hemodynamic compromise or graft dysfunction. There were 4 deaths post-HTx (range, 11 days to 9 months). The median follow-up of 9 survivors was 1.7 years (0.3 to 3.7 years). Of 7 patients > 6 months post-HTx, no AMR or cardiac allograft vasculopathy was observed at a mean of 1.9+1.1 years post-HTx and no cardiac allograft vasculopathy.Despite aggressive management, acute cellular rejection and AMR occurred frequently early post-HTx. An algorithm of B cell-directed strategies can be effective in managing these patients with reasonable intermediate-term outcomes.
Philip E S Palmer
Authors: A. Leake
Journal: BMJ (2013)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Philip E S Palmer Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Multifunctional liposomes loaded with paclitaxel and artemether for treatment of invasive brain glioma
Authors: Xiu-Ying Li, Yao Zhao, Meng-Ge Sun, Ji-Feng Shi, Rui-Jun Ju, Cheng-Xiang Zhang, Xue-Tao Li, Wei-Yu Zhao, Li-Min Mu, Fan Zeng, Jin-Ning Lou, Wan-Liang Lu
Journal: Biomaterials (2014)
Progressive Impairment of Pulmonary Antibacterial Defense Mechanisms Associated with Prolonged Oxygen Administration.
Authors: Gary L. Huber
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Progressive Impairment of Pulmonary Antibacterial Defense Mechanisms Associated with Prolonged Oxygen Administration.Gary L. Huber, M.D., F. Marc LaForce, M.D.Gary L. Huber, M.D.Search for more papers by this author, F. Marc LaForce, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-808_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe lung is the primary target organ for normobaric oxygen toxicity. In addition, pulmonary bacterial infection is a frequent complication of prolonged oxygen therapy. A progressive, dose-related deterioration in pulmonary antibacterial defense mechanisms was induced in 215 laboratory mice by exposure to oxygen tensions of 650 mm Hg for 12, 24, 48, 72 and 96 hr. An additional 65 mice, maintained in atmospheric air (oxygen tension: 140 mm Hg), were used as controls. An aerosol inoculum of radiotracer tagged (32P)Staphylococcus aureus(FDA 209P, type 42D) was delivered to oxygen treated and control animals for 30 min. The animals were... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPulmonary Oxygen ToxicityConcanavalin A distribution in polymorphonuclear leukocytes and alveolar macrophages during hyperoxiaFunctional activities of alveolar macrophages in rat exposed to hyperoxia (normobaric O2)Pulmonary Oxygen ToxicityBlood loss and factors affecting pulmonary antibacterial defensesDehydration and factors affecting pulmonary antibacterial defenses 1 May 1970Volume 72, Issue 5Page: 808-808KeywordsFood and Drug AdministrationLungsOxygenPulmonary diseasesResearch laboratoriesStaphylococcus aureusToxicity Issue Published: 1 May 1970 PDF downloadLoading ...
3D Real-Time Intracardiac Echocardiographic Visualization of Atrial Structures Relevant to Atrial Fibrillation Ablation
Authors: Neil Brysiewicz, Teferi Mitiku, Kamran Haleem, Paras Bhatt, Mustapha Al-Shaaraoui, Jude F. Clancy, Mark A. Marieb, Lissa Sugeng, Joseph G. Akar
Journal: JACC. Cardiovascular imaging (2014)
The Flow of Lymph
Authors: Joseph G. Hall
Journal: New England Journal of Medicine (1969)

THE lymph of reptiles and amphibia is returned to the blood circulation by the action of actual lymph hearts.1 Lymph hearts, as such, do not occur in mammals, and the source of the energy that is necessary to return the lymph to the bloodstream is still the subject of debate.Broadly speaking, there are two schools of thought. The "traditional" view, which finds expression in the standard reviews,2 , 3 is that extralymphatic sources of energy, such as the movements of skeletal muscles and the pulsations transmitted from arteries, fortuitously compress the valved lymphatic vessels and thus force the lymph in a . . .
Bone microarchitecture is more severely affected in patients on hemodialysis than in those receiving peritoneal dialysis
Authors: Solenne Pelletier, Nicolas Vilayphiou, Stéphanie Boutroy, Justine Bacchetta, Elisabeth Sornay-Rendu, Pawel Szulc, Walid Arkouche, Fitsum Guebre-Egziabher, Denis Fouque, Roland Chapurlat
Journal: Kidney International (2012)
The Relation of Blood Pressure and Flow to the Development and Regression of Experimentally Induced Pulmonary Arteriosclerosis
Authors: DONALD J. FERGUSON, RICHARD L. VARCO
Journal: Circulation Research (1955)

Systemic artery-pulmonary artery shunts have been made in dogs and the relation between pulmonary artery pressure and blood flow and the development of vascular lesions has been studied. Arteriolar medial hypertrophy and intimal proliferation are not necessarily incited by a large blood flow, but such lesions are more readily induced by an end-to-end than by an end-to-side type of shunt. Intimal proliferation is not associated with stainable alterations in elastic tissue or lipid infiltration. Vascular lesions do not readily regress when the inciting factor is removed.
Inhibition of miR-92a improves re-endothelialization and prevents neointima formation following vascular injury
Authors: J.-M. Daniel, D. Penzkofer, R. Teske, J. Dutzmann, A. Koch, W. Bielenberg, A. Bonauer, R. A. Boon, A. Fischer, J. Bauersachs, E. van Rooij, S. Dimmeler, D. G. Sedding
Journal: Cardiovascular Research (2014)

MicroRNA (miR)-92a is an important regulator of endothelial proliferation and angiogenesis after ischaemia, but the effects of miR-92a on re-endothelialization and neointimal lesion formation after vascular injury remain elusive. We tested the effects of lowering miR-92a levels using specific locked nucleic acid (LNA)-based antimiRs as well as endothelial-specific knock out of miR-92a on re-endothelialization and neointimal formation after wire-induced injury of the femoral artery in mice.MiR-92a was significantly up-regulated in neointimal lesions following wire-induced injury. Pre-miR-92a overexpression resulted in repression of the direct miR-92a target genes integrin α5 and sirtuin1, and reduced eNOS expression in vitro. MiR-92a impaired proliferation and migration of endothelial cells but not smooth muscle cells. In vivo, systemic inhibition of miR-92a expression with LNA-modified antisense molecules resulted in a significant acceleration of re-endothelialization of the denuded vessel area. Genetic deletion of miR-92a in Tie2-expressing cells, representing mainly endothelial cells, enhanced re-endothelialization, whereas no phenotype was observed in mice lacking miR-92a expression in haematopoietic cells. The enhanced endothelial recovery was associated with reduced accumulation of leucocytes and inhibition of neointimal formation 21 days after injury and led to the de-repression of the miR-92a targets integrin α5 and sirtuin1.Our data indicate that inhibition of endothelial miR-92a attenuates neointimal lesion formation by accelerating re-endothelialization and thus represents a putative novel mechanism to enhance the functional recovery following vascular injury.
Abstract 1738: Significance of thymidylate synthase expression in prostate cancer
Authors: Yoichi Mizutani, Yu Edagawa, Hiroshi Fujisue, Shinya Uchimoto, Kohei Koyama, Naokazu Ibuki, Teruo Inamoto, Takanobu Ubai, Hayahito Nomi, Hruhito Azuma, Yoji Katsuoka
Journal: Cancer Research (2010)

Abstract Introduction : Thymidylate synthase (TS) is an important rate-limiting enzyme in the pathway of de novo DNA synthesis. Several reports demonstrated that TS expression was up-regulated in various cancers. 5-fluorouracil (5-FU) is an anti-cancer agent used clinically against a variety of cancers including prostate cancer. TS is a target enzyme for 5-FU. 5-FU inhibits DNA synthesis by binding TS and folic acid. We then investigated the expression of TS in prostate cancer and investigated its prognostic significance. Materials and Methods : Total 100 prostate cancer tissue specimens were obtained from patients who underwent radical prostatectomy for prostate cancer. Fifty-two patients did not received neoadjuvant hormonal therapy, and the rest 48 patients received neoadjuvant hormonal therapy. We examined prostate cancer tissues and normal prostate tissues for TS expression by immunohistochemistry. TS expression was regarded as positive, when more than 25% cells showed positive staining. If less than 25% were positive staining, TS expression was regarded as negative. Results : TS in prostate cancer tissues expressed at higher levels in patients without neoadjuvant hormonal therapy, compared with normal prostate tissues. TS expression was positive in approximately 70% prostate cancer tissues. In contrast, TS expression was observed in about 10% normal prostate tissues. The positive rate of TS expression in Stage T3 prostate cancer was higher than that in Stage T2 prostate cancer. In addition, the rate of positive TS expression in Gleason score 7 or greater prostate cancer was higher than that in Gleason score less than 7 prostate cancer. Patients with prostate cancer with negative TS expression without neoadjuvant hormonal therapy had a longer postoperative recurrence-free rate than those with positive expression in the 5 year follow-up. The rate of positive TS expression in prostate cancer tissues was significantly down-regulated in patients who received neoadjuvant hormonal therapy, compared with no neoadjuvant hormonal therapy. Especially, the rate of positive TS expression in stage T2 prostate cancer tissues was decreased by neoadjuvant hormonal therapy. Conclusions : The present study has demonstrated for the first time that TS expression may be a prognostic parameter for prostate cancer patients undergoing radical prostatectomy, and that TS may be a molecular therapeutic target for prostate cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1738.
Preoperative Diagnosis of Choledochal Cyst by Hepatoscintography
Authors: Lewis E. Williams, John H. Fisher, Richard A. Courtney, Donald B. Darling
Journal: New England Journal of Medicine (1970)

THE preoperative diagnosis of congenital cystic dilatation of the common bile duct (eholedochal cyst) continues to represent a challenging surgical and radiologic exercise. The classic triad of abdominal pain, jaundice and an abdominal mass suggests the diagnosis.1 Direct radiographic demonstration by intravenous cholangiography is possible only during a remission of the jaundice.2 In a case recently encountered at the Boston Floating Hospital for Infants and Children the eholedochal cyst was shown by liver scanning with the use of radioactive rose bengal despite the presence of clinical and chemical jaundice.Case ReportA 3-year-old girl was admitted to the hospital in . . .
Therapeutic effect of all-trans retinoic acid on rats with anti-GBM antibody glomerulonephritis
Authors: Susumu Oseto, Toshiki Moriyama, Noritaka Kawada, Katsuyuki Nagatoya, Masanobu Takeji, Akio Ando, Tadashi Yamamoto, Enyu Imai, Masatsugu Hori
Journal: Kidney International (2003)
DEMONSTRATION AND CHARACTERIZATION OF TWO DISTINCT HUMAN LEUKOCYTIC PYROGENS
Authors: Charles A. Dinarello, Nathan P. Goldin, Sheldon M. Wolff
Journal: The Journal of Experimental Medicine (1974)

Human monocytes and neutrophils were separated from buffy coats of blood obtained from normal donors. Following incubation with heat-killed staphylococci, monocyte preparations contained 20 times more pyrogenic activity in the supernatant media than did supernates from an equal number of neutrophils. During purification of these pyrogens it was discovered that these cell preparations each produced a distinct and different pyrogen. The pyrogen obtained from neutrophils had a mol wt of 15,000 following Sephadex G-75 gel filtration, an isoelectric point of 6.9, and could be precipitated and recovered from 50% ethanol at –10°C. In contrast, the pyrogen derived from monocyte preparations had a mol wt of 38,000, an isoelectric point of 5.1, and was destroyed in cold ethanol. Both molecules were unaffected by viral neuraminidase but biologically destroyed at 80°C for 20 min and with trypsin at pH 8.0. The febrile peak produced by partially purified neutrophil pyrogen occurred at 40 min while that from monocytes was at 60 min. In addition, monocyte pyrogen produced more sustained fevers for the same peak elevation as neutrophil pyrogen. These studies demonstrate for the first time two chemically and biologically distinctive pyrogens derived from circulating human white blood cells and have important implications for our understanding of the pathogenesis of fever in man.