tbuckley/cabot-search huggingface dataset:
Long‐term benefits of immunoadsorption in β<sub>1</sub>‐adrenoceptor autoantibody‐positive transplant candidates with dilated cardiomyopathy
Authors: Michael Dandel, Gerd Wallukat, Angela Englert, Hans B. Lehmkuhl, Christoph Knosalla, Roland Hetzer
Journal: European Journal of Heart Failure (2012)
NARRATION
Authors: Leon J. Warshaw
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ELECTRIC OZONATION IN NEURALGIA.
Authors: G Lenox Curtis
Journal: JAMA (1902)

The term neuralgia may be applied to all pains found in animal tissue that may be regarded as being nearly or quite in a perfect physical condition, especially if the pains have become chronic. To designate the locality of the cause of pain, which may or may not be in the region of pain, and leaving out what may be regarded as functional disturbance, we may mention, for illustration of my subject, facial neuralgia, gastralgia, myalgia, as of the pain in myelitis and pyelitis, all of which are only different phases of disturbances called neuralgia. The locality of the keenest pains may be in the parts suggested by those names or they may be at greater or less distance. Neuralgia in and about the face and mouth is generally easily determined, but there are cases where there seem to be complications. Other forms of pain, such as gout, rheumatism, sciatica
Clinical outcome of “high-risk” vs “elective” patients undergoing percutaneous coronary intervention: Results from IMPACT-II
Authors: James J. Ferguson, Timothy J. McDonough, Seth J. Worley, William J. French, John C. Corbelli, James C. Blankenship, Daniel Carey, Frank V. Aguirre, Robert A. Harrington, J.David Talley, A.Michael Lincoff, William C. Sheldon, Bonnie H. Weiner, Jon R. Resar, James E. Tcheng, Eric J. Topol, Robert M. Califf
Journal: Journal of the American College of Cardiology (1996)
Using Computers in the Practice of Medicine: Professional and Clinical Guidelines for Managing Your Practice and Improving Patient Care
Authors: Edward P. Hoffer
Journal: JAMA (1985)

This is a difficult book to review. It contains a large amount of excellent material, along with even larger amounts of dubious value. With the increasing influence computers are making on all aspects of medical practice, the computer-naive practitioner needs a single source to which to turn for an overview. Dr Solomon's book tries to be such a source, with virtually every aspect of computer use in medicine discussed. What is lacking is some sense of perspective. I had the impression that this book had been written in a stream-of-consciousness style, with ideas thrown out as fast as they occurred to the author. There are brief synopses of such topics as computer-assisted diagnosis, computers and imaging, and computer-interpreted electrocardiograms, which are excellent for their length but which deserve more extensive treatment. At the same time, 50 pages list in its entirety one programmed medical history. Similarly, 43 pages are devoted
Glucose-lactate interrelationships: effect of ethanol
Authors: Robert A. Kreisberg, Alan M. Siegal, W. Crawford Owen
Journal: Journal of Clinical Investigation (1971)

The effect of ethanol on the interrelationship of lactate and glucose metabolism was investigated in eight human volunteers. Lactate and glucose kinetics and intervconversion rates were determined by the sequential administration of L-(+) lactate-U-(14)C and glucose-1-(14)C over an 8 hr period. After a 12 hr fast, the glucose turnover and recycling rates were 94.0 +/-3.8 (SEM) and 13.7 +/-1.1 mg/kg per hr, respectively. Approximately 50% of the glucose turnover or 40.7 +/-2.1 mg/kg per hr was converted to lactate, accounting for 50% of the lactate turnover rate. Lactate turnover and lactate conversion to glucose were 81.8 +/-6.2 and 16.7 +/-1.1 mg/kg per hr, respectively. Approximately 20% of the glucose turnover was derived from lactate under these conditions. During the administration of ethanol, the blood lactate concentration doubled and the lactate turnover rate declined slightly. Lactate conversion to glucose was markedly inhibited, decreasing from 16 to 5 mg/kg per hr, and the per cent of the glucose turnover derived from lactate decreased from 18 to 6. Despite the marked inhibition of lactate conversion to glucose, neither the blood glucose concentration nor the glucose turnover rate changed. Both glucose recycling and glucose conversion to lactate were decreased, indicating that ethanol inhibited peripheral glucose utilization. There was no difference in the degree of inhibition of lactate incorporation into glucose produced by ethanol when nonfasted subjects were compared with two subjects who had fasted for 48-72 hr despite the presence of hypoglycemia in the latter. These results indicate that starvation is not a prerequisite for ethanol inhibition of gluconeogenesis from lactate in humans but is necessary for the development of hypoglycemia. Inhibition of lactate incorporation into glucose in nonfasted subjects is probably masked by a concomitant increase in glycogenolysis which prevents hypoglycemia. Ethanol decreases glucose conversion to lactate as well as lactate conversion to glucose, thus inhibiting the Cori cycle.
Delivery of Herpes Simplex Virus Vectors through Liposome Formulation
Authors: Xinping Fu, Xiaoliu Zhang
Journal: Molecular Therapy (2001)

Viral vectors have been widely used as gene delivery vehicles for both experimental and clinical investigations. Although these vectors are capable of achieving high gene transduction efficiency in vitro, one of the major limitations facing the therapeutic viral vectors is that the preexisting host anti-vector immunity can substantially reduce their transduction efficiency in vivo. This is especially of concern when the therapeutic remedy requires repeated systemic administration. Here we report the delivery of herpes simplex virus (HSV) derived vectors through liposome formulation. In these studies, we have prepared HSV vectors in three different forms for liposome formulation: purified viral DNA (obtained from a bacterial artificial chromosome containing an infectious HSV genome), HSV capsids, and intact viral particles. All three forms of HSV were readily transfected into cultured cells and infectious virus was efficiently generated. Furthermore, introduction of HSV vectors as DNA/liposome complexes improved in vivo transduction efficiency, by effectively evading the host anti-HSV immunity during systemic administration. We conclude that viral vectors such as HSV can be systemically delivered through liposome formulation for safe and repeated administration for gene transduction or oncolytic purposes.
Cadmium from soil amended with sewage sludge: effects and residues in swine.
Authors: L G Hansen, T D Hinesly
Journal: Environmental Health Perspectives (1979)

Liquid digested sewage sludge from a Chicago waste treatment plant was applied to experimental corn plots starting in 1968. The treatment plant received a high proportion of industrial effluent and the sludge averaged about 200 ppm Cd (dry weight). Corn grain harvested from the plots in 1974 was fed to growing swine for 56 days, and other swine were permitted to forage on the plots during the winters of 1975-76 and 1976-77. The sludge-fertilized corn contained higher concentrations of nutrient and toxic elements, but did not interfere with swine performance. Minor changes in hepatic microsomal oxidases and red blood cells accompanied significant increases in renal Cd and decreases in hepatic Fe. Swine foraging on these plots ingested considerable amounts of sludge soil and accumulated significantly higher concentrations of renal Cd. At lower rates of sludge application the swine outperformed those foraging both on control plots and those receiving heavy sludge applications in terms of weight gain, in-utero piglet survival, blood hemoglobin, and tissue Fe concentrations.
The sebum excretion rate in rosacea
Authors: J.L. BURTON, R.J. PYE, GAY MEYRICK, SAM SHUSTER
Journal: British Journal of Dermatology (2006)

Journal Article The sebum excretion rate in rosacea Get access J.L. BURTON, J.L. BURTON Department of Dermatology Bristol Royal Infirmary, Bristol Search for other works by this author on: Oxford Academic Google Scholar R.J. PYE, R.J. PYE Department of Dermatology Bristol Royal Infirmary, Bristol Search for other works by this author on: Oxford Academic Google Scholar GAY MEYRICK, GAY MEYRICK Department of Dermatology Bristol Royal Infirmary, Bristol Search for other works by this author on: Oxford Academic Google Scholar SAM SHUSTER SAM SHUSTER Wellcome Research Laboratories, University Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 92, Issue 5, 1 May 1975, Pages 541–543, https://doi.org/10.1111/j.1365-2133.1975.tb03122.x Published: 01 May 1975 Article history Accepted: 16 September 1974 Published: 01 May 1975
Metastatic hepatocellular carcinoma of the esophagus: an unusual cause of upper gastrointestinal bleeding
Authors: S.-L. Yan, Y.-H. Hung, T.-H. Yang
Journal: Endoscopy (2007)

Hepatocellular carcinoma (HCC) is a hypervascular tumor that frequently metastasizes through systemic vessels or the portal system. Lung, adrenal gland and bone are the common sites of distant metastasis of HCC [1]. On the other hand, the incidence of gastrointestinal tract metastasis of HCC is typically low, with the stomach, duodenum and colon being the most commonly involved organs [2]. Esophageal metastasis is especially rare in patients with HCC [1]. The major symptoms of metastatic HCC of the esophagus include dysphagia and gastrointestinal bleeding [3] [4] [5]. Endoscopically, metastatic HCC of the esophagus may present as a submucosal tumor or a polypoid mass [3] [4] [5]. We report here a case of metastatic HCC of the esophagus, which presented as an oozing polypoid lesion at upper gastrointestinal endoscopy.
ALBUMINURIA BOTH AMONG PATIENTS WITH TYPE 2 DIABETES AND AMONG NON-DIABETIC SUBJECTS SIGNIFICANTLY PREDICTS CARDIOVASCULAR EVENTS INDEPENDENTLY FROM THE ANGIOGRAPHICALLY DETERMINED CORONARY ARTERY STATE
Authors: Philipp Rein, Christoph Saely, Alexander Vonbank, Heinz Drexel
Journal: Journal of the American College of Cardiology (2014)
Abstract 5278: Circulating microRNAs profile as a novel biomarker for osteosarcoma.
Authors: Wendy Allen-Rhoades, Lyazat Kurenbekova, Susan Hilsenbeck, Tsz-Kwong Man, Lawrence Donehower, Jason T. Yustein
Journal: Cancer Research (2013)

Abstract Osteosarcoma (OS) is the primary bone tumor in children, with approximately 400 cases each year diagnosed in patients under the age of twenty. Current therapies can achieve long-term relapse free survival rates near 75% for those with localized disease, while survival rates for patients with overt metastatic disease at diagnosis are often less than 20%. Without adjuvant chemotherapy, over 80% of children will develop metastatic or recurrent disease and all patients require long term monitoring. However, there are no reliable, non-invasive biological markers to detect the presence or progression of disease, assess therapy response, or provide upfront risk stratification. The present method for detecting and monitoring disease status in OS is radiographic imaging which is often difficult to interpret. MicroRNAs (miRNAs) are evolutionarily conserved, stable, small non-coding RNA molecules that are key post-transcriptional regulators and are ideal candidates for circulating biomarker development due to their stability in plasma, ease of isolation with high sensitivity, and the unique expressions associated with specific disease states. As such, we have developed a signature profile of circulating miRNAs utilizing a novel genetically engineered mouse model of OS that can discriminate between mice with and without OS. Specifically, we have determined that circulating miR-205 is decreased 3.2-fold in mice with disease compared to disease-free mice, whereas miR-574-3p, miR-214, and miR-335-5p are increased 1.4, 1.9, and 2.9 fold respectively in the diseased mice. Finally, based upon prior studies utilizing other cancer models, we believe that we will be able to directly translate these findings from the mouse model to patients afflicted with osteosarcoma. Citation Format: Wendy Allen-Rhoades, Lyazat Kurenbekova, Susan Hilsenbeck, Tsz-Kwong Man, Lawrence Donehower, Jason T. Yustein. Circulating microRNAs profile as a novel biomarker for osteosarcoma. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5278. doi:10.1158/1538-7445.AM2013-5278
Recurrent Pancreatitis And Fat-Induced Hyperlipoproteinemia
Authors: David F. Cross
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Recurrent episodes of severe abdominal pain occasionally pose difficult diagnostic problems. Among the less common disorders are diseases such as acute intermittent porphyria, chronic lead poisoning, the periodic fevers, Dietl's crisis, and abdominal migraine. Since the description of the clinical syndrome associated with the primary hyperlipidemias,<sup>1,2</sup>hyperlipoproteinemia has been added to this list. A young man over a four-year period experienced multiple attacks of severe abdominal pain, necessitating repeated hospitalization and a laparotomy. Diagnoses entertained at various times were cholecystitis, chronic relapsing pancreatitis, adhesions, perinephric abscess, partial bowel obstruction, influenza syndrome, and appendicitis. Fat-induced hyperlipoproteinemia (type V) has now been proven. Presumptive and definitive diagnosis can be made with ease once one is acquainted with its distinctive clinical manifestations. <h3>Report of a Case:—</h3> A 27-year-old man was admitted to the US Naval Station Hospital, Argentia, Newfoundland, on Dec 27, 1967, with severe abdominal pain. The patient
Gender Differences in the Trajectory of Recovery in Health Status Among Young Patients With Acute Myocardial Infarction
Authors: Rachel P. Dreyer, Yongfei Wang, Kelly M. Strait, Nancy P. Lorenze, Gail D’Onofrio, Héctor Bueno, Judith H. Lichtman, John A. Spertus, Harlan M. Krumholz
Journal: Circulation (2015)

Background— Despite the excess risk of mortality in young women (≤55 years of age) after acute myocardial infarction (AMI), little is known about young women’s health status (symptoms, functioning, quality of life) during the first year of recovery after an AMI. We examined gender differences in health status over time from baseline to 12 months after AMI. Methods and Results— A total of 3501 AMI patients (67% women) 18 to 55 years of age were enrolled from 103 US and 24 Spanish hospitals. Data were obtained by medical record abstraction and patient interviews at baseline hospitalization and 1 and 12 months after AMI. Health status was measured by generic (Short Form-12) and disease-specific (Seattle Angina Questionnaire) measures. We compared health status scores at all 3 time points and used longitudinal linear mixed-effects analyses to examine the independent effect of gender, adjusting for time and selected covariates. Women had significantly lower health status scores than men at each assessment (all P values &lt;0.0001). After adjustment for time and all covariates, women had Short Form-12 physical/mental summary scores that were −0.96 (95% confidence interval [CI], −1.59 to −0.32) and −2.36 points (95% CI, −2.99 to −1.73) lower than those of men, as well as worse Seattle Angina Questionnaire physical limitations (−2.44 points lower; 95% CI, −3.53 to −1.34), more angina (−1.03 points lower; 95% CI, −1.98 to −0.07), and poorer quality of life (−3.51 points lower; 95% CI, −4.80 to −2.22). Conclusion— Although both genders recover similarly after AMI, women have poorer scores than men on all health status measures, a difference that persisted throughout the entire year after discharge.
Incarcerate free radicals
Authors: Neil D. Granger, Dale A. Parks
Journal: Hepatology (1986)

We have investigated the possible protective effect of superoxide dismutase and allopurinol in a rat model of mild and severe hepatic necrosis produced by Corynebacterium parvum with or without endotoxin. Histology showed a sinusoidal mononuclear cell infiltrate with multiple granulomata but variable degrees of hepatic necrosis. In the severe hepatic injury model there was a reduction in mortality, associated with a decrease in histologic and biochemical evidence of hepatic necrosis, after treatment with superoxide dismutase. This protective effect was not demonstrated with partially heat-inactivated superoxide dismutase. In the mild hepatic injury model similar trends in reduction of serum levels of hepatic enzymes were observed after treatment with both superoxide dismutase and allopurinol. These results indicate that oxygen-derived free radicals may play an important role in the pathogenesis of hepatic injury in the rat.
Fractures in the Elderly: A Guide to Practical Management
Authors: David A. Ontjes
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice.
Authors: A H Cross, T P Misko, R F Lin, W F Hickey, J L Trotter, R G Tilton
Journal: Journal of Clinical Investigation (1994)

Previous work from our laboratory localized nitric oxide to the affected spinal cords of mice with experimental autoimmune encephalomyelitis, a prime model for the human disease multiple sclerosis. The present study shows that activated lymphocytes sensitized to the central nervous system encephalitogen, myelin basic protein, can induce nitric oxide production by a murine macrophage cell line. Induction was inhibited by amino-guanidine, a preferential inhibitor of the inducible nitric oxide synthase isoform, and by NG-monomethyl-L-arginine. Aminoguanidine, when administered to mice sensitized to develop experimental autoimmune encephalomyelitis, inhibited disease expression in a dose-related manner. At 400 mg aminoguanidine/kg per day, disease onset was delayed and the mean maximum clinical score was 0.9 +/- 1.2 in aminoguanidine versus 3.9 +/- 0.9 in placebo-treated mice. Histologic scoring of the spinal cords for inflammation, demyelination, and axonal necrosis revealed significantly less pathology in the aminoguanidine-treated group. The present study implicates excessive nitric oxide production in the pathogenesis of murine inflammatory central nervous system demyelination, and perhaps in the human disease multiple sclerosis.
Risk factors for clinically important adverse events after protamine administration following cardiopulmonary bypass
Authors: Stephen E Kimmel, Mikkael A Sekeres, Jesse A Berlin, Norig Ellison, Verdi J DiSesa, Brian L Strom
Journal: Journal of the American College of Cardiology (1998)

Objectives. The purpose of this study was to determine risk factors for adverse events following protamine administration after cardiopulmonary bypass. Background. Intravenous protamine administration is associated with a risk of severe systemic reactions. However, risk factors for these events have not been well delineated, thus hampering development of preventive strategies. Methods. A case–control study nested within a cohort of consecutive patients undergoing surgery requiring cardiopulmonary bypass was performed. The primary case definition included those events (pulmonary hypertensive and systemic hypotensive) occurring within 10 min of protamine administration in the absence of other measurable causes of hemodynamic compromise. Results. Comparing the 53 cases to the 223 control subjects, three risk factors were independently associated with events (multivariable odds ratio [95% confidence interval]): neutral protamine Hagedorn insulin use (8.18 [2.08, 32.2]); fish allergy (24.5 [1.24, 482.3]), and a history of nonprotamine medication allergy (2.97 [1.25, 7.07]). These risk factors demonstrated an increasingly strong association with progressively more specific case definitions. An estimated 39% of cardiopulmonary bypass patients had one or more of these risk factors. Prior intravenous protamine, central venous pressure prior to protamine, preoperative ejection fraction and the need for inotropes when coming off bypass did not exhibit statistically significant associations with events (all p > 0.15). Prior protamine allergy was associated specifically with an increased risk of pulmonary hypertension (multivariable odds ratio 189; 95% confidence interval 13, 2,856). Conclusions. Immunologic factors are important in predisposing individuals to protamine reactions, and a substantial proportion of patients are at considerably increased risk. Strategies to reduce the risk of protamine-associated events are needed.
131I Hippuran Renogram in Acute Renal Failure
Authors: M. E. Mayo, P. J. Hilton, N. F. Jones, R. W. Lloyd-Davies, D. N. Croft
Journal: BMJ (1971)

A hippuran renogram pattern of the type usually interpreted as indicating urinary tract obstruction was seen in acute tubular necrosis and was present both in the oliguric and in the diuretic phase. It seems that in acute renal failure the renogram does not distinguish urinary tract obstruction from intrinsic renal disease.
Paclitaxel in Pretreated Metastatic Penile Cancer: Final Results of a Phase 2 Study
Authors: Giuseppe Di Lorenzo, Piera Federico, Carlo Buonerba, Nicola Longo, Giacomo Cartenì, Riccardo Autorino, Sisto Perdonà, Matteo Ferro, Pasquale Rescigno, Carmine D'Aniello, Elide Matano, Vincenzo Altieri, Giovannella Palmieri, Ciro Imbimbo, Sabino De Placido, Vincenzo Mirone
Journal: European Urology (2011)