tbuckley/cabot-search huggingface dataset:
TWO CASES OF CIRCULATORY DISTURBANCE OF THE BRAIN
Authors: C. EUGENE RIGGS
Journal: JAMA (1913)

We thought it might be of interest to report to this section two quite rare and extremely interesting cases of circulatory disturbance of the brain. <h3>Case 1.</h3> —The first case is, in all probability, a thrombosis of the posterior-inferior cerebellar artery. It was referred to us by Dr. D. C. Jones. <h3>History.</h3> —The patient is a man, aged 47, married, traveling salesman. He uses alcohol in moderation and tobacco in excess. Personal history is negative, except that the patient had gonorrhea at the age of 22; he denies lues. For the past four years he has had bilateral occipital headaches, more marked on the right side and more severe in the recumbent posture. Family history is negative. <h3>Present Trouble.</h3> —The present disease began July 12, 1912. While out walking, the patient suddenly developed an attack of dizziness and staggering, so marked that he had to lean against a building to keep from falling. This lasted about ten
Botulism: a potentially common problem.
Authors: J M Shneerson
Journal: Thorax (1989)

Botulism: a potentially common problemBotulism is rare in almost all developed countries and has been for many years.Why then should we fear that it might become a problem?The answer is that its incidence is closely linked to methods of food prepara- tion, and these are continually changing.New meth- ods, such as vacuum preparation of food, provide ideal conditions for the production of botulinum toxin.Botulism is unknown after eating fresh food.Fer- mentation, pickling, canning, smoking, and similar processes that require anaerobic conditions enable Clostridium botulinum to produce its toxin.Botulism may follow unless the food is adequately heated before consumption.Although one of the most potent toxins known, botulinum toxin is easily inactivated by, for instance, heating to 80°C for only five minutes.Botulinum toxin prevents the release of acetyl- choline from the presynaptic membrane of synapses and the neuromuscular junction.'Seven toxins
Music in the endoscopy suite: a meta-analysis of randomized controlled studies
Authors: D. Rudin, A. Kiss, R. Wetz, V. Sottile
Journal: Endoscopy (2007)

See also: Commentaire de travail de D. Rudin et al., pp. 507Endoscopy 2007; 39(06): 577-577DOI: 10.1055/s-0032-1306941
Determination of the Moments of Inertia of the Human Body and its Limbs
Authors: W. Bell
Journal: British Journal of Sports Medicine (1989)

Thus, I would like to suggest that there is now a place for using bouncing and ballistic stretching alongside the well recommended yoga and PNF stretching.Its place and its reason for use must be carefully ascertained.The ultimate goal of stretching should be to achieve functional range-not potential range.
Children lose a devoted medical champion
Authors: Phil Gunby
Journal: JAMA (1984)

A festschrift can be a tribute during life or it can be a memorial. The MarchAmerican Journal of Diseases of Childrenfestschrift to C. Henry Kempe, MD, has turned out to be both. Scarcely had the leader in pediatric medicine whom it honored received his copy—and expressed his pleasure and appreciation—when his life was claimed by the heart condition (complicated by respiratory problems) that had altered the pattern of the later years of his career. He died March 8 in Honolulu, where he and his wife, Ruth Svibergson Kempe, MD, had moved after Denver's mile-high altitude was found to be aggravating his condition. He would have been 62 this month. Kempe had gone to Denver in 1956 at the age of 34 from the University of California, San Francisco, School of Medicine—his alma mater—to be professor and chairman, Department of Pediatrics, at the University of Colorado School of Medicine.
Treatment of xanthelasma palpebrarum by 1064-nm Q-switched Nd:YAG laser: a study of 11 cases
Authors: T. Fusade
Journal: British Journal of Dermatology (2007)

Background Xanthelasma palpebrarum (xanthelasma) is a common disease involving the eyelids. It consists of yellowish plaques of esterified cholesterol situated in the middle and superficial layers of the dermis. Many techniques, including laser treatments, have been proposed to destroy these lesions. A preliminary study demonstrated the efficacy of 1064‐nm Q‐switched Nd:YAG laser in treating xanthelasma. Objectives To present the results of a prospective study using 1064‐nm Q‐switched Nd:YAG laser to treat xanthelasma. Methods Thirty‐eight lesions in 11 patients were treated. Results The results observed after a single treatment by Q‐switched Nd:YAG laser were scored as good or excellent in eight patients, i.e. for 26 of 38 lesions. Conclusions The treatment of xanthelasma by 1064‐nm Q‐switched Nd:YAG laser is a valuable treatment option to eliminate lesions, with rapid and good quality healing. The absence of any associated skin destruction allows treatment to be repeated when necessary.
Facing the Complex Issues of Pediatric AIDS: A Public Health Perspective
Authors: Michael T. Osterholm, Kristine L. MacDonald
Journal: JAMA (1987)

Almost seven years have passed since the first recognition of the acquired immunodeficiency syndrome (AIDS) in this country, and during the past four years we have been able to identify many of the clinical and epidemiologic consequences of human immunodeficiency virus (HIV) infection. Although children with AIDS were recognized early in the epidemic, the impact of pediatric AIDS on clinical medicine and society in general is only now being fully appreciated. In this issue ofTHE JOURNAL, Landesman et al<sup>1</sup>provide us with important insights into the pediatric HIV infection problem of today and the AIDS problem of tomorrow through their survey of women delivered of infants at King's County Hospital Center in Brooklyn, NY. In their study of HIV seroprevalence in cord blood samples from 602 infants delivered in an inner-city municipal hospital, Landesman and colleagues found a demographic and HIV risk factor history similar to what is currently
Urinary Glycol Ether Metabolites in Women and Time to Pregnancy: The PELAGIE Cohort
Authors: Ronan Garlantézec, Charline Warembourg, Christine Monfort, Laurence Labat, Juha Pulkkinen, Nathalie Bonvallot, Luc Multigner, Cécile Chevrier, Sylvaine Cordier
Journal: Environmental Health Perspectives (2013)

Background: Glycol ethers are present in a wide range of occupational and domestic products. Animal studies have suggested that some of them may affect ovarian function.Objective: We examined the relation between women's exposure to glycol ethers and time to pregnancy.Methods: We used chromatography coupled to mass spectrometry to measure eight glycol ether metabolites in urine samples from randomly selected women in the PELAGIE mother–child cohort who had samples collected before 19 weeks of gestation. Using time to pregnancy information collected at the beginning of the pregnancy (women were asked how many months it took for them to conceive), we estimated associations between metabolite levels and time to pregnancy in 519 women with complete data using discrete-time Cox proportional hazards models to adjust for potential confounders.Results: We detected glycol ether metabolites in 6% (for ethoxyacetic acid) to 93% (for phenoxyacetic and butoxyacetic acids) of urine samples. Phenoxyacetic acid was the only metabolite with a statistically significant association with longer time to pregnancy [fecundability OR = 0.82; 95% CI: 0.63, 1.06 for the second and third quartile combined; fecundability OR = 0.70; 95% CI: 0.52, 0.95 for a fourth-quartile (≥ 1.38 mg/L) vs. first-quartile concentration (< 0.14 mg/L)]. This association remained stable after multiple sensitivity analyses.Conclusion: Phenoxyacetic acid, which was present in most of the urine samples tested in our study, was associated with increased time to pregnancy. This metabolite and its main parent compound, 2-phenoxyethanol, are plausible causes of decreased fecundability, but they may also be surrogates for potential coexposures to compounds frequently present in cosmetics.Citation: Garlantézec R, Warembourg C, Monfort C, Labat L, Pulkkinen J, Bonvallot N, Multigner L, Chevrier C, Cordier S. 2013. Urinary glycol ether metabolites in women and time to pregnancy: the PELAGIE cohort. Environ Health Perspect 121:1167–1173; http://dx.doi.org/10.1289/ehp.1206103
Abstract 492: Esophageal administration of manganese superoxide dismutase plasmid liposomes (MnSOD-PL) reverses thoracic irradiation sensitivity of nitric oxide synthase one homologous recombinant negative (NOS1 -/-) mouse
Authors: Michael W. Epperly, Malolan S. Rajagopalan, Jean-Claude Rwigema, Brandon Stone, Julie Goff, Tracy M. Dixon, Darcy Franicola, Joel S. Greenberger
Journal: Cancer Research (2010)

Abstract NOS1 -/- mice are more sensitive to 29 Gy thoracic or 9.5 Gy total body irradiation (TBI) than control C57BL/6NHsd, or NOS2 -/- or NOS3 -/- mice (p &amp;lt; 0.0001 and p = 0.0006). Histological examination of the esophagus, lungs, heart and intestine revealed no explanation of the rapid death of NOS1 -/- mice. Blood and bone marrow isolates six days after TBI (1 day before the NOS1 -/- mouse death) showed similar decrease in blood counts for all the mouse strains. NOS1 -/- mouse marrow irradiated to doses ranging from 0 to 8 Gy showed CFU-GM, BFU-E and CFU-GEMM radiosensitivity similar to that from control mice. There were also no differences in serum electrolytes, liver or renal function tests in irradiated NOS1 -/- compared to C57BL/6NHsd mice. RNA extracted from esophagus, stomach or intestine at day 0, 1 or 6 following 9.5 total body irradiation showed by qualitative RT-PCR analysis of TNF-σ, NF-κβ, and INF-γ similar cytokine expression between NOS1 -/- and C57BL/6NHsd mice. NOS1 -/- and C57BL/6NHsd mice were irradiated to 9.5 Gy total body or 20 Gy to the thoracic cavity and observed by video camera. NOS1 -/- mice had seizures before death following both TBI or thoracic irradiation, while no seizures were detected in dying C57BL/6NHsd mice. NOS1 -/- mice irradiated to 9.5 Gy to the brain (with the remainder of the body shielded) did not produce death from seizures. NOS1 -/- were intraesophageally administered MnSOD-PL (100 µg plasmid DNA) and irradiated to 20 Gy to the upper body 24 hr later. NOS1 -/- mice administered MnSOD-PL had normalized survival compared to control irradiated NOS1 -/- mice: 50% survival at 12 days for irradiated control NOS1 -/- mice compared to 128 days for MnSOD-PL treated NOS1 -/- mice (p = 0.0311). The data indicate that esophageal neuronal abnormalities which cause pyloric stenosis in the strain may be responsible for both the rapid thoracic irradiation sensitivity leading to seizure and its reversal by intraesophageal MnSOD-PL gene therapy. Supported by NIAID grant U19AI068021, and NIH grant T32AG21885 Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 492.
F(ab)′2-mediated neutralization of C3a and C5a anaphylatoxins: a novel effector function of immunoglobulins
Authors: Milan Basta, Fredric Van Goor, Stefano Luccioli, Eric M. Billings, Alexander O. Vortmeyer, Lajos Baranyi, Janos Szebeni, Carl R. Alving, Michael C. Carroll, Ira Berkower, Stanko S. Stojilkovic, Dean D. Metcalfe
Journal: Nature Medicine (2003)
Required levels of nasal continuous positive airway pressure during treatment of obstructive sleep apnoea
Authors: F Series, I Marc, Y Cormier, J La Forge
Journal: European Respiratory Journal (1994)

The improvement in the severity of obstructive sleep-related breathing disorders during nasal continuous positive airway pressure (NCPAP) therapy can account for the decrease in the required NCPAP level with time. The aim of this study was to prospectively quantify the changes in the required NCPAP level over time of use in sleep apnoea-hypopnoea syndrome (SAHS). Forty sleep apnoea-hypopnoea patients were evaluated before and during the time course of NCPAP therapy. The effective NCPAP level was defined as the positive pressure level that abolished apnoeic and hypopnoeic events and snoring in all sleep stages and sleep positions. This pressure level was determined within 2 weeks after baseline diagnostic sleep study. Sleep studies with NCPAP and NCPAP titration were performed after 2 (n = 40), 8 (n = 40), and 20 (n = 24) months of NCPAP therapy. The initial effective NCPAP level was 9.6 +/- 0.4 cmH2O. It progressively decreased to 8.8 +/- 0.4, 7.9 +/- 0.4 and 7.7 +/- 0.5 after 2, 8 and 20 months, respectively; the difference being significant between the first three NCPAP nights. There was a poor relationship between the changes in the effective NCPAP and changes in weight recorded at the different visits. There was a weak negative relationship between the changes in NCPAP and the previous NCPAP level. In 13 patients, the apnoea-hypopnoea index (AHI) remained > 10 n.h-1 at the first NCPAP trial because the effective NCPAP level was not tolerated. Despite a suboptimal NCPAP level, their sleep architecture improved, and they all reported a subjective improvement in diurnal hypersomnolence.(ABSTRACT TRUNCATED AT 250 WORDS)
Prevalence of Bipolar Disorders
Authors: Franco Benazzi
Journal: Psychotherapy and Psychosomatics (2005)

Letters| April 11 2005 Prevalence of Bipolar Disorders Subject Area: Psychiatry and Psychology Franco Benazzi Franco Benazzi E. Hecker Outpatient Psychiatry Center, Forlì, Italy Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (2005) 74 (3): 190–191. https://doi.org/10.1159/000084006 Article history Published Online: April 11 2005 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Franco Benazzi; Prevalence of Bipolar Disorders. Psychother Psychosom 1 April 2005; 74 (3): 190–191. https://doi.org/10.1159/000084006 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 2005Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Terminal care at home: perspective from general practice.
Authors: A Haines, A Booroff
Journal: BMJ (1986)

A survey of general practitioners in north west London was undertaken by questionnaire to elicit information about problems that they had had in looking after patients at home who were terminally ill and about their perceived needs for both training and support services. The response rate was 73% (196 of 268 doctors). Thirty two per cent of respondents frequently or always had problems in controlling pain in such patients, and 45% frequently or always had difficulties in coping with the emotional distress of patients or relatives, or both. Between 20 and 30% of respondents often had problems with inadequate support services, poor communication with support services and hospital specialists, and difficulty in admitting patients who were terminally ill. Roughly half of the respondents thought that more training in managing pain and other symptoms that are associated with terminal illness would be of great help, and a similar response was noted for bereavement counselling. About 40% of respondents indicated that training in communicating with dying patients would be a great help in improving care and three quarters that more home nursing support was necessary.
Apoptosis Induction by the Core Biopsy Procedure
Authors: Jenny C. Chang, Heidi Weiss, Syed Mohsin
Journal: Journal of Clinical Oncology (2005)

EDITOR: Dr Menard et al support our observation of tumor reduction in their pilot study, and cytocidal rather than cytostatic mechanism of action of trastuzumab.We acknowledge that there could be other mechanisms by which trastuzumab may assert its effect, including antibody dependent cytotoxicity through an intact immune system.Nonetheless, in our study, apoptosis was observed in 20 of 25 patients with matched baseline and week 1 specimens after trastuzumab exposure.If core biopsies were in fact responsible for the induction of apoptosis, then all the samples would demonstrate induction of apoptosis.Moreover, subsequent biopsies did not confer further increase in cleaved caspase 3, thereby reducing the likelihood that the biopsy procedure contributed to the increase in apoptosis.Finally, in neoadjuvant chemotherapy trials, similar biopsy procedures were performed.Most importantly, we and others have performed multiple biopsies of the primary tumor at the same time without intervening therapy, and demonstrated no increase in apoptosis with biopsies taken from different sites within the tumor. [1]2][3] We therefore stand by our findings that the main mechanism of action of trastuzumab is by induction of apoptosis, and not by cell cycle inhibition.
Application of Serum Microimmunoelectrophoresis to the Clinical Evaluation of Patients with Hypersensitivity Vasculitis and Other Allergic Diseases.
Authors: Charles E. Buckley
Journal: Annals of Internal Medicine (1964)

s1 April 1964Application of Serum Microimmunoelectrophoresis to the Clinical Evaluation of Patients with Hypersensitivity Vasculitis and Other Allergic Diseases.Charles E. Buckley III, M.D., Herbert O. Sieker, M.D., F.A.C.P.Charles E. Buckley III, M.D.Search for more papers by this author, Herbert O. Sieker, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-730_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMicroimmunoelectrophoresis of mixtures of proteins has been demonstrated to be a useful tool for the identification of antigenically distinguishable normal and abnormal plasma proteins in the dysgammaglobulinemias and in malignancies of the reticuloendothelial system. Despite its potential usefulness, it has not been applied as an aid in the clinical evaluation of diseases in which allergic diathesis occurs. The normal and abnormal plasma proteins in 75 patients with illness involving alterations in immunity or the immune proteins were examined by microimmunoelectrophoresis. A modification of the method of Scheidigger using 2 per cent Noble agar and Tris-chloride, pH 8.6, 0.05 ionic strength... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Durham, North Carolina PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1964Volume 60, Issue 4Page: 730-731KeywordsAllergic diseasesAntigensHypersensitivityImmunityPlasma proteinsVasculitis Issue Published: 1 April 1964 PDF DownloadLoading ...
Theories in health care and research: Theories of disability in health practice and research
Authors: M. Oliver
Journal: BMJ (1998)

This is the fifth in a series of six articles on the importance of theories and values in health research

All health care and research are influenced by theories. This paper considers the influence of implicit and explicit theories1 on interventions and research on disabled people. Another important influence is the experience of disabled people, and their increasing insistence that their voices be heard at all stages of research about their lives.2

### Summary points

The health care that disabled people receive is influenced by theories

Positivist theory remains the dominant influence on health care given to disabled people

Other theories are beginning to have a significant influence

The rise of these theories is posing important questions for health care and research

Over the past 20 years, writings by disabled people have transformed our understanding of the real nature of disability. They move beyond the personal limitations that impaired individuals may face, to social restrictions imposed by an unthinking society. Disability is understood as a social and political issue rather than a medical one, and this leads to critical questioning of medical interventions:attempts to cure impairments or to restore “normal” bodily functioning. Instead, social and political solutions are sought, to challenge disabling discrimination.

This radically different view is called the social model of disability, or social oppression theory.3While respecting the value of scientifically based medical research, this approach calls for more research based on social theories of disability if research is to improve the quality of disabled people's lives. Definitions are central to understanding theories of impairment and disability.4 In 1986 Disabled Peoples International made a clear distinction:impairment is the functional limitation within the individual caused by physical, mental or sensory impairment; disability is the loss or limitation of opportunities to take part in the normal life of …
Meningococcal Disease in New York City, 1973 to 1978
Authors: Edward I. Galaid, Charles E. Cherubin, John S. Marr, Sam Schaefler, Joseph Barone, William Lee
Journal: JAMA (1980)

In the period 1973 through 1978, the New York City Department of Health serogrouped 648 isolates of<i>Neisseria meningitidis</i>and investigated 259 cases of meningococcal meningitis and meningococcemia. Although meningitis and septicemia were mainly due to groups B and C, groups Y and W-135 caused nearly one third of the cases. There was no difference in mortalities when disease caused by the classic groups A, B, and C was compared with disease caused by the new serogroups X, Y, Z, W-135, and Z'. Most isolates from the respiratory tract were from the new serogroups, especially Z and Z' (some from patients with pneumonia), as were most of those from the genitourinary tract, anal canal, and miscellaneous sites. Group X was infrequently seen. Although most of the isolations of these groups of<i>N meningitidis</i>are apparently from asymptomatic carriers, Y and W-135 do cause a substantial number of acute symptomatic infections, in particular, septicemia. (<i>JAMA</i>244:2167-2171, 1980)