tbuckley/cabot-search huggingface dataset:
Catheter Ablation for the Treatment of Electrical Storm in Patients With Implantable Cardioverter-Defibrillators
Authors: Corrado Carbucicchio, Matteo Santamaria, Nicola Trevisi, Giuseppe Maccabelli, Francesco Giraldi, Gaetano Fassini, Stefania Riva, Massimo Moltrasio, Manuela Cireddu, Fabrizio Veglia, Paolo Della Bella
Journal: Circulation (2008)

Electrical storm (ES) caused by recurrent episodes of ventricular tachycardia (VT) can cause sudden death in patients with implantable cardioverter-defibrillators and adversely affects prognosis in survivors. Catheter ablation has been proposed for treating ES, but its long-term effect in a large population has never been verified.Ninety-five consecutive patients with coronary artery disease (72 patients), idiopathic dilated cardiomyopathy (10 patients), and arrhythmogenic right ventricular dysplasia/cardiomyopathy (13 patients) undergoing catheter ablation for drug-refractory ES were prospectively evaluated. Short-term efficacy was defined by a complete protocol of programmed electric stimulation and by in-hospital outcome; long-term analysis addressed ES recurrence, cardiac mortality, and VT recurrence. Pleomorphic/nontolerated VTs required electroanatomic and noncontact mapping in 48 and 22 patients, respectively, and percutaneous cardiopulmonary support in 10 patients. An epicardial approach was used in 10 patients. After 1 to 3 procedures, induction of any clinical VT(s) by programmed electrical stimulation was prevented in 85 patients (89%). ES was acutely suppressed in all patients; a minimum period of 7 days with stable rhythm was required before hospital discharge. At a median follow-up of 22 months (range, 1 to 43 months), 87 patients (92%) were free of ES and 63 patients (66%) were free of VT recurrence. Eight of 10 patients with persistent inducibility of clinical VT(s) had ES recurrence; 4 of them died suddenly despite appropriate implantable cardioverter-defibrillator intervention. All together, 11 of 95 patients (12%) died of cardiac-related reasons. In the group of patients presenting with all clinical VTs acutely abolished, no ES recurrence was documented, and cardiac mortality was significantly lower compared with the group of patients showing > or = 1 clinical VT still inducible after catheter ablation.Advanced strategies of catheter ablation applied to a large population of patients are effective in the short-term treatment of ES. By preventing ES recurrence, catheter ablation may play a protective role over the long term and, together with long-term pharmacological therapy, may favorably affect cardiac mortality.
Hypothermia during chemotherapy for Hodgkin's disease.
Authors: M J Jackson, S J Proctor, R C Leonard
Journal: BMJ (1983)

All isolates resistant to trimethoprim before 1980 were also resistant to sulphonamide.Since then we have isolated an increasing number of strains resistant to trimethoprim and sensitive to sulphonamide; six during 1980, 11 during 1981, and 30 during 1982.Most (27) were isolated from general practice.
Obsessive-Compulsive Disorder Limited to Pregnancy
Authors: Iulian Iancu, Elie Lepkiflcer, Pinhas Dannon, Moshe Kotler
Journal: Psychotherapy and Psychosomatics (1995)

The relationship between obsessive-compulsive disorder and pregnancy is reviewed in the light of recent reports concerning the frequent onset and exacerbation of obsessive-compulsive disorder during pregnancy. We present the case of a young woman who developed obsessive-compulsive disorder during a pregnancy and recovered completely after delivery. Five years afterwards she is still symptom-free. Several possible explanations for this unusual occurrence are discussed.
Fluorescence spectroscopy for identification of atherosclerotic tissue
Authors: F Bosshart, U Utzinger, O M Hess, J Wyser, A Mueller, J Schneider, P Niederer, M Anliker, H P Krayenbuehl
Journal: Cardiovascular Research (1992)

Vessel perforation and limited steerability of the laser light are the major limitations of laser angioplasty. To improve steerability fluorescence spectroscopy has been proposed for identification of atherosclerotic plaques. The aim was to investigate this.Fluorescence spectroscopy with three different excitation wavelengths (325 nm, 380 nm, 450 nm) was tested in an emission range of 400 nm to 600 nm. Intensity ratios at 480/420 nm were determined in different types of blood vessels. Necropsy material from 40 patients (punch biopsies of 4 mm diameter from the coronary and carotid artery as well as from the ascending and descending aorta) was studied spectroscopically. Histological alterations of the vessel wall were assessed by a semiquantitative score (0 to 10 points): (a) normal tissue, 0 to 2 points (mean = 0.25; n = 38); (b) mild atherosclerotic lesions, 3 to 5 points (mean = 3.35; n = 39); (c) severe atherosclerotic lesions, greater than or equal to 6 points (mean = 6.75; n = 43).Best spectroscopic results were obtained with an excitation wavelength of 325 nm. In samples with severe atherosclerotic lesions the fluorescence spectra showed a significant reduction of the emitted wavelength intensities when compared to normal tissue. There was a clear separation of the fluorescence spectra between normal and mild as well as between normal and severe atherosclerotic lesions; normal tissue showed an increased intensity in the range from 420 nm to 540 nm, whereas atherosclerotic lesions had no or only a small peak at 480 nm. There was a significant correlation between the semiquantitative score (n = 120) and the fluorescence ratio at 480/420 nm (excitation wavelength 325 nm) with a correlation coefficient of 0.87. The spectroscopic results showed no differences between the samples taken from different types of vessels.Fluorescence spectroscopy allows a reliable identification of normal and atherosclerotic lesions. The close correlation between the emitted light intensity ratio at 480/420 nm and the histological alterations of the vessel wall suggests a relationship between vessel wall fluorescence and the atherosclerotic alterations of the wall.
The Role of Professionalism and Self-regulation in Detecting Impaired or Incompetent Physicians
Authors: Matthew K. Wynia
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer Surveillance in Ulcerative Colitis: A Survey of Patients' Knowledge
Authors: R. J. Robinson, A. R. Hart, J. F. Mayberry
Journal: Endoscopy (1996)

The present study aimed to investigate the level of knowledge concerning colorectal carcinoma and its screening and treatment in a group of patients with long-standing and extensive ulcerative colitis.A postal questionnaire was sent to 61 patients with long-standing and extensive ulcerative colitis. They were asked about their risk of carcinoma, about the existence of screening facilities, and about the treatment of colorectal carcinoma.Forty-three completed questionnaires were returned. Eighty-six per cent of patients were aware of the increased risk of carcinoma. Only 44% knew that it was possible to screen for colorectal carcinoma. Forty-seven per cent of patients were unaware that carcinoma detected at screening would require surgical removal.Large numbers of patients are unaware of the existence of screening facilities for colorectal cancer, and are ignorant of the treatment of the disease. Increased public information is required to improve compliance with screening programmes, and to enable patients to take part in decisions about their management.
Tomorrow's Hospital: A Look to the Twenty-first Century
Authors: Bernard S. Bloom
Journal: JAMA (1997)

Hospitals  It took 100 years from the development of the first modern hospital in the United States (arguably the Johns Hopkins Hospital) for hospitals to become the paramount medical care institutions. We will look back longingly to the 1980s as the time when hospitals were the temples of treatment. They were the workshops of the most knowledgeable specialists, educated students and trainees, produced vast quantities of research, used all the latest technologies, and had the bulk of power, prestige, and resources. People were born and died there, and every medical event was provided for in between. This was all paid for willingly by private and public sectors, and patient and physician preferences reinforced beliefs and behavior. It took but the last 10 years to turn the halcyon days into a financial and organizational shambles for hospitals. The inability or unwillingness of hospitals and physicians generally to deal with economic realities
Complications of Silicone Elastomer Prostheses
Authors: Robert M. Nalbandian
Journal: JAMA (1977)

To the Editor.—  The report by Christie et al apparently correctly notes that silicone elastomer prostheses may produce foreign body reaction in a regional lymph node and synovitis. However, these mild inflammatory reactions have not been placed in proper clinical perspective. The authors correctly state, Thousands of silicone elastomer... joint prostheses have been inserted, but they do not assert the astonishing rarity of their findings. Based on their own text, the features in their two cases are each quite literally unique. Even the most accommodating statistical evaluation puts the incidence of these minor complications in the miniscule order of thousandths of 1%. Were the incidence of other surgical complications as comparably low.  It is quite evident that no crippled arthritic patient should, where appropriate, forego the restoration of function by the insertion of the Swanson silicone elastomer prostheses because of unjustified concern for the correct but unique findings reported.
Morgagni's Syndrome
Authors: R. Asher
Journal: BMJ (1949)

BRMITIH 915 was marked by well-defined clinical and histological characteristics.In their opinion this did not exclude a tuberculous aetiology, nor did it favour it.That sarcoidosis can be followed by tuberculosis may be due to a special predisposition.Uehlinger's case, in which sarcoidosis was folloWed by fulminant tuberculous septicaemia, may sup- port this, but in the reviewer's opinion it was a single, exceptional case.As a rule, when sarcoidosis is followed by tuberculosis the latter is ordinary in appearance and course and lesions of both conditions can be found in intimate association with each other.The authors reject the virus hypothesis.From their suggestion that sarcoidosis should be catalogued as a disease of the reticulo-endothelial system they seem to expect some compensation for our ignorance of its aetiology.
Subclinical Symptoms of Panic Disorder: New Insights into Pathophysiology and Treatment
Authors: Giovanni A. Fava, Lara Mangelli
Journal: Psychotherapy and Psychosomatics (1999)

The aim of this review was to survey the available literature on prodromal and residual symptoms of panic disorder. Both a computerized (Medline) and a manual search of the literature were performed. In a substantial proportion of patients with panic disorder with agoraphobia a prodromal phase can be identified. Most patients report residual symptoms despite successful treatment. Residual symptoms upon remission have a prognostic value. There appears to be a relationship between residual and prodromal symptomatology (the rollback phenomenon). Appraisal of subclinical symptomatology in panic disorder has important implications as to the pathophysiological model of disease, its conceptualization and treatment.
Pharmaceutical treatment of symptomatic vertebral fractures in primary care
Authors: D J Torgerson
Journal: Annals of the Rheumatic Diseases (2004)

<b>Background:</b> Vertebral fractures are associated with a reduction in quality of life and are an important predictor of other non-spine fractures. Previous work has shown that up to 60% of patients with a vertebral fracture identified in primary care remain untreated. <b>Objective:</b> To examine the prevalence of pharmaceutical treatment and predictors of treatment in a primary care setting. <b>Methods:</b> Case–control study using the general practice research database (GPRD). All women aged 50 years and over with a first diagnosis of a vertebral fracture since 1990 were identified and matched with a control by age and practice. Appropriate use of a pharmaceutical agent was defined as a prescription occurring within 30 days of the diagnosis being recorded. <b>Results:</b> We identified 2719 women with the same number of controls. Within 30 days of diagnosis 61% of women were prescribed treatment, compared with only 3% of the controls. Bisphosphonate was the single most important treatment prescribed. Predictors of any drug treatment included: year of fracture (most recent year increased the likelihood of treatment); age (younger patients were more likely to receive treatment); history of back pain; low body weight; history of steroid use. <b>Conclusions:</b> Treatment of diagnosed vertebral fractures is becoming more common. Treated patients tend to be younger but to have a higher prevalence of clinical risk factors than untreated patients. There remain significant numbers of patients who are not offered treatment.
Angiography in the Management of Aneurysms of the Abdominal Aorta
Authors: David C. Brewster, Alvaro Retana, Arthur C. Waltman, R. Clement Darling
Journal: New England Journal of Medicine (1975)

The course of 190 patients with aneurysm of the abdominal aorta who underwent preoperative aortography was reviewed to determine the safety and usefulness of that procedure. There were no serious complications; minor problems occurred in only four patients and did not affect operative therapy. In 21 patients, the clinical impression of aneurysm was found to be incorrect. Surgically important findings included suprarenal extension of the aneurysm in nine patients, and demonstration of stenotic lesions in the renal arteries (37 patients) or superior mesenteric artery/celiac axis (17 patients). Helpful findings were associated aneurysms (26 patients), multiple renal arteries (28 patients), and occlusive lesions in the lower extremities or aortocranial system in 82 and eight patients respectively. Such information was found useful in planning operative procedures and minimizing operative time and blood loss. In our experience, angiography in patients with aneurysm of the abdominal aorta is both safe and informative.
Health Care Systems in Transition: Cyprus/Germany/Slovakia/Estonia
Authors: Jane Salvage
Journal: BMJ (2005)

T he European Union is here to stay, whatever the outcome of referendums, budget battles, or the Eurovision song contest. It has and will have a profound impact on health issues, even in the United Kingdom, where “Europe” is often talked about as though it were somewhere else. Health, and increasingly health care, is no respecter of frontiers; its determinants range from imported diseases to health tourism, from drug trafficking to the migration of doctors.

The study of health and health care in neighbouring countries is therefore increasingly important. We may consult, employ, or work alongside their professionals; treat their patients or send them ours; and encounter illnesses contracted there. Willingly or not, we may participate in experiments launched after fact finding missions to foreign capitals—most notoriously the former health secretary Alan Milburn's Madrid visit that inspired foundation hospitals. The search for different solutions drives us to compare and contrast, …
Contributions to the Physiology and Pathology of the Mammalian Heart
Authors: C. S. Roy, J. G. Adami
Journal: BMJ (1892)

The observations upon which the following communication is based were made upon the Mammalian heart under conditions as nearly approaching the normal as we were able to make compatible with the employment of accurate recording methods. Our object throughout has been to study the mechanism of the Mammalian heart in situ by methods of research which would give to the subject a degree of exactness as closely as possible approximating to that of the work of Kronecker, Coats, Gaskell, Heidenhain, &c., on the excised hearts of cold-blooded animals, and of N. Martin and his school on the excised Mammalian heart. It need hardly be said that the mode of action of the heart of warm-blooded Mammals is a much more difficult subject of study than that of the heart of a Frog or Tortoise. The hearts of these latter animals are simpler in structure, to begin with, than those of a Rabbit, Cat, or Dog, and if the subject be further simplified by excising the organ and keeping thereby under control the nerve impulses which reach it, as well as the pressure and composition of the blood which enters and leaves its cavities (supposing the heart to be supplied with blood at all), some of the difficulties are greatly reduced. In the excised surviving heart of cold-blooded animals we have a piece of machinery whose action and attributes can be studied with a degree of accuracy and ease which corresponds with its comparative simplicity.
Inefficacy of extracorporeal photochemotherapy in the treatment of B‐Cell chronic lymphocytic leukemia: Preliminary results
Authors: Janet S. Wieselthier, Mary C. Japowicz, Thomas L. Rothstein, Thomas L. Yu, Tom Anderson, Howard K. Koh
Journal: American Journal of Hematology (1992)

Abstract Because extracorporeal photopheresis has been shown to be clinically effective in Sezary syndrome, a disease characterized by a circulating malignant clone, we initiated a pilot study of its use in B‐cell chronic lymphocytic leukemia (B‐CLL) to see if it could be similarly effective. We treated three patients with Rai stage III and IV B‐CLL with photopheresis (3 consecutive days a week every 3 weeks) and followed serial clinical and immunologic parameters. While we noted no major toxicity, there was neither clinical response to treatment nor marked improvement in white counts or mitogen assays. We conclude that photopheresis was not effective in inducing remission in this pilot study of advanced stage B‐CLL patients. © 1992 Wiley‐Liss, Inc.
Dietary Prophylaxis of Allergic Disease in Children
Authors: Douglas E. Johnstone, Arthur M. Dutton
Journal: New England Journal of Medicine (1966)

IN 1953 Glaser and Johnstone1 reported on the use of soybean milk as an aid in the prophylaxis of allergic disease in children. They concluded that if one withheld cow's milk, beef, egg and wheat from the diets of potentially allergic children from the time of birth until the age of six to nine months, only one quarter as many of these children acquired major respiratory allergies compared to their siblings and another nonrelated control group. They also reported that the incidence of atopic eczema in infants on the restricted diet was only one fourth as great as in the . . .
Single-Void Urine Samples Can Be Used To Estimate Quantitative Microalbuminuria
Authors: David M Nathan, Carol Rosenbaum, V Daniel Protasowicki
Journal: Diabetes Care (1987)

The excretion of small quantities of urinary albumin (microalbuminuria) may predict renal failure in diabetes. The measurement of microalbuminuria with radioimmunoassays has been based on 24-h, overnight, and 3- to 4-h collections. To determine whether single-void urine samples can be used to estimate 24-h excretion, we compared the results of 24-h outpatient urine collections with single-void samples corrected for creatinine from diabetic and nondiabetic subjects. The overall correlation of single-void sample results expressed as microgram albumin per milligram creatinine with 24-h excretion (mg/24 h) was excellent (r = .82, P less than .001). More important, in the diabetic patients the sensitivity and specificity of detecting 24-h microalbuminuria in the abnormal range were at least 94 and 96%, respectively. Single-void urine specimens adjusted for creatinine discriminate between normal and abnormal levels of microalbuminuria, as determined in 24-h urine collection, with high specificity and sensitivity.
Delirium From Transdermal Scopolamine in an Elderly Woman
Authors: Renzo Rozzini
Journal: JAMA (1988)

<h3>To the Editor.—</h3> Perhaps too little attention is paid by practitioners to central anticholinergic effects of drugs in the elderly. <h3>Report of a Case.—</h3> Recently, a 77-year-old woman was hospitalized for sudden global loss of memory, disorientation, and clouded sensorium after a journey to a holiday resort. Clinical and diagnostic evaluation did not indicate any abnormality. The patient had no history of drug intake. She was released after two days owing to spontaneous remission of the symptoms. The woman remained well for the remaining 15 days of her vacation, after which she went back home. On reaching her home, she experienced the same global disturbance of cognition as previously and again had to be hospitalized. Results of diagnostic evaluation were normal. After a more detailed drug history was taken, however, it was found that the elderly woman had used a scopolamine transdermal preparation (retroauricular) to prevent car sickness on her
Tobacco companies launch legal action against plain packaging
Authors: M. Sweet
Journal: BMJ (2011)

The giant tobacco company Philip Morris has launched legal action against Australia’s plans to make plain packaging of cigarettes compulsory from next year and plans to seek compensation for its losses.

Philip Morris Asia says that the plain packaging legislation will breach Australia’s bilateral investment treaty with Hong Kong, where the company is based, and argues that removing brands from packaging devalues the company’s intellectual property.

Philip Morris is also using a similar legal strategy to try to block tobacco control measures in Uruguay, under the Switzerland-Uruguay bilateral investment treaty.

Anne Edwards, a spokeswoman for Philip Morris International, said that the company believed it had …