tbuckley/cabot-search huggingface dataset:
David Christopher Simmonds Gough
Authors: Peter Doyle
Journal: BMJ (2005)

Consultant paediatric urologist Royal Manchester Children's Hospital, Pendlebury, Manchester (b Bristol 1947; q Liverpool 1969; FRCS, FRACS, DCH), d 29 March 2005.​2005.




Figure 1




David became a leading figure in paediatric urology. He developed a special interest and expertise in congenital abnormalities of the lower urinary track, particularly bladder exstrophy. He was an enthusiastic proponent and a founder member of the British Association of Paediatric Urologists. David did his house jobs at Broadgreen Hospital and then embarked on his surgical career training initially in Cambridge and Cardiff, where he developed his interest in paediatric surgery. He then spent some two years at the Royal Melbourne Children's Hospital before obtaining his appointment at the Royal Manchester Children's Hospital. Cars were a lifelong passion, to which he added collecting art and enjoying good wine. He leaves a wife, Elizabeth, and three children.
Intravascular Gamma Radiation for In-Stent Restenosis in Saphenous-Vein Bypass Grafts
Authors: Ron Waksman, Andrew E. Ajani, R. Larry White, Rosanna C. Chan, Lowell F. Satler, Kenneth M. Kent, Augusto D. Pichard, Ellen E. Pinnow, Anh B. Bui, Steven Ramee, Paul Teirstein, Joseph Lindsay
Journal: New England Journal of Medicine (2002)

Intracoronary radiation therapy is effective in reducing the recurrence of in-stent stenosis in native coronary arteries. We examined the effects of intravascular gamma radiation in patients with in-stent restenosis of saphenous-vein bypass grafts.
The human tissue bill
Authors: Peter Furness, Richard Sullivan
Journal: BMJ (2004)

The human tissue billCriminal sanctions linked to opaque legislation threaten research T he new human tissue bill is making its way towards the statute book for England, Wales, and Northern Ireland.Although a necessary response to the organ retention scandal involving the Royal Liverpool Children's NHS Trust, this bill goes far wider than tissues derived from post mortems. 1 It applies to any material that contains human cellseven urine and sputum.Using such material for research or for training not "incidental to the diagnostic process" will be a criminal offence unless "appropriate" consent has been obtained.Possible penalties include three years in jail.Punitive criminal sanctions coupled with opaque legislation threaten ethical and essential research as well as routine NHS activities.Incidental and appropriate have yet to be defined by a new human tissue authority, which will have powers of licensing and inspection.But the government has repeatedly said that consent must be explicit, 2 even in relation to medical training using residual blood samples that would otherwise be incinerated. 3 We know that the public does not regard surgically resected tissue in the same way as postmortem tissue. 4 Putting aside the question of whether residual urine samples really deserve legal protection comparable to that accorded to a dead baby's heart, the question remains-can it work, and does it command both professional and public confidence?Does this bill focus so much on individual rights that the benefits to society of research and training are ignored?Laboratory staff cannot ask for consent after the patient has gone home, and it is usually impossible to know which samples will be of value for training or research at the time of sampling.Therefore, if staff training and hence care for patients are not to suffer the wishes of all patients must be recorded and made available to laboratory staff.This is the government's intention.One suggestion is that tick boxes should be placed on all pathology request forms.In a pilot in High Wycombe 68% of forms had neither "consent" nor "refuse" ticked.A clause on the standard surgical consent form has been suggested, although such forms are not used for blood sampling.A trial in Leeds showed that the laboratory could trace only 48% of the forms, and 40% of those were not complete.Many forms contained contradictory statements, indicating that surgeons had not actually explained the issues to patients. 5Consent without information is invalid 6 ; how can invalid consent be appropriate?Therefore, one possible outcome is that residual specimens, which could be used
Occasional Use of Marijuana
Authors: Richard H. Schwartz
Journal: JAMA (1988)

<h3>To the Editor.—</h3> A Florida physician wrote a letter inquiring about the risks of occasional use of marijuana.<sup>1</sup>Dr Herrington, a Milwaukee psychiatrist, replied that the infrequent use of marijuana (less than once a week) probably will not result in ill effects, unless one of the infrequent acute reactions to marijuana happens to occur. I am certified by the American Medical Society on Alcohol and other Drug Dependencies and I have long been a teacher of the underappreciated toxic effects of the crude drug cannabis.<sup>2</sup>I would have said to the Florida physician that all marijuana smokers are not equal. Those who have parents or even grandparents who were dependent on alcohol or other intoxicants, those with fragile personality structures, those with latent or chronic schizophrenia, those who engage in risk-taking behaviors, and those who have not negotiated adolescence successfully seem to be at greater risk for injury
Treatment of the Urethral Syndrome in Women
Authors: Robert Zufall
Journal: JAMA (1963)

A SYNDROME familiar to urologists is that which affects women and consists of urinary frequency; dysuria; "pressure"; pain in the low back, flank, and suprapubic area; occasional bleeding (most often blood on the toilet paper used after voiding); and often malaise and "tiredness." Although these symptoms are those of inflammation of the lower urinary tract, corroborative physical and laboratory findings are minimal if not absent altogether. There may be some suprapubic tenderness, and the genitalia and urethral meatus remain unremarkable. Urinalyses and pyelograms show normal results, as do tests of residual urine. The urethra has been commonly blamed for this syndrome, and many experienced observers find urethral stenosis, edema, hyperemia, granularity, polyps at the neck of the bladder, or exudate on the trigone.<sup>1</sup>Others doubt the significance of these findings and do not feel that they can be correlated with the symptomatology. Allergic and psychic factors,<sup>2</sup>senile atrophy,
INCREASED INTRACRANIAL PRESSURE IN EMPHYSEMA CAUSED BY OXYGEN INHALATION
Authors: John C. Mithoefer
Journal: JAMA (1952)

Respiratory depression followed by delirium and coma has developed in several patients with chronic pulmonary emphysema while they were receiving oxygen therapy in this hospital. I have studied some of these patients as well as some normal subjects in an effort to determine the mechanism of production of this phenomenon. Three normal subjects and four patients with chronic lung disease were studied. Their ages and diagnoses are listed in table 1. Brief summaries of the clinical states of the four diseased patients are given below. <h3>PROCEDURE</h3> The subject lay on his left side, and an indwelling needle was placed in the brachial artery. A lumbar puncture needle was inserted, connecting the subarachnoid space to a spinal fluid monometer. The subject breathed through a rubber mouth piece attached to a three-way valve by which connection could be made either to a 9L spirometer containing 100% oxygen or to room air. During
Vasectomy in the surgery.
Authors: E R Seiler
Journal: BMJ (1972)

Difficulties encountered in some 30 vasectomies performed under general anesthesia included location and maintenance of contact with the vas and ligation of the vas.  Patients experienced pain under local anesthesia.  It is concluded that the operation should be carried out under general anesthesia and that vasectomy is not ideally suited for general practice.
Onset of Mechanical Activation of Mammalian Heart Muscle in Calcium- and Strontium-Containing Solutions
Authors: DIRK L. BRUTSAERT, VICTOR A. CLAES
Journal: Circulation Research (1974)

The time course of the relationship between force, shortening velocity, and length during shortening was examined in mammalian heart muscle in calcium (Ca)-containing solutions and solutions with strontium (Sr) substituted for Ca by imposing load clamps of various amplitudes at various times during external shortening. The onset of this force-velocity-length relationship was measured by abruptly unloading the muscle at different times to nearly zero external load--by zero load clamping the muscle--under conditions of optimal damping; the subsequent unloaded active muscle shortening velocity was then analyzed with respect to time and length. In Ca- containing solution, the unloaded velocity in the length range around 90% of L max rose within 16% of the time required to reach peak isometric force to a maximum level appropriate to a given contractile state. Subsequently, the force-velocity-length relationship was independent of time at any load over a well-determined portion of external shortening. In Sr-containing solution, unloaded active velocity rose much slower to reach a steady state after 30-35% of the time to peak force, and the time independence of the force-velocity-length relationship was delayed until after this time. In Na-free Sr-containing solution, maximum unloaded shortening velocity and the time-independent portion of the force-velocity-length relationship were achieved again within 20% of the time to peak force. The effects of substitution of Sr for Ca thus resemble those of caffeine on mammalian heart muscle. These findings suggest a close relationship between the time course of the force-velocity-length relationship and the degree of activation.
The leukotriene D4-receptor antagonist, ICI 204,219, relieves symptoms of acute seasonal allergic rhinitis.
Authors: A L Donnelly, M Glass, M C Minkwitz, T B Casale
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

The efficacy and safety of single oral doses of the leukotriene D4-receptor antagonist, ICI 204,219, were tested in subjects with acute seasonal allergic rhinitis. Subjects who were enrolled in the double-blind, placebo-controlled trial spent 8 h/d for two consecutive days in a park at the peak of ragweed season (counts > 1,000 grains/m3). Subjects (n = 164) who had sufficient symptoms during a 3-h baseline period on Day 1 were randomized to treatment with 10 (n = 33), 20 (n = 33), 40 (n = 33), or 100 mg (n = 32) of ICI 204,219 or placebo (n = 33). Rhinitis symptoms (nasal congestion, sneezing, rhinorrhea, itchy nose, throat and palate, and eye symptoms) were recorded hourly in the park and three times each evening at home. Blood samples were collected twice daily to determine plasma levels of ICI 204,219. Nasal congestion improved (p < 0.01) most consistently from the evening of Day 1 through Day 2 after treatment with 20- and 40-mg doses of ICI 204,219 versus placebo. Sneezing and rhinorrhea (p < or = 0.05) also improved on Day 2 for subjects who received 20- and 40-mg doses of ICI 204,219 compared with placebo. Mean symptoms scores for the entire day showed that 20 mg of ICI 204,219 was the minimally effective dose in this trial. The onset of action for all treatment groups, including placebo, was within the first 2 h of dosing. No serious adverse events were reported during the trial. ICI 204,219 was well tolerated and relieved symptoms of acute seasonal allergic rhinitis.
Goring by Bull and Bell Palsy
Authors: J. H. Lossing
Journal: JAMA (1974)

To the Editor.—  Dr. Thomas, in a recent contribution (229:139, 1974), recalled that Tapia syndrome, unilateral 10th and 12th nerve palsies, was caused in the classic case by being gored by a bull. It has always been a curiosity to me, and useful in teaching, that the classic case of  palsy, as I understand it, was caused by a bull-goring, in fact, by a bull-tossing: The horn entered behind the upright portion of the left jaw, tearing the portio dura of the seventh nerve where it came forward from the stylo-mastoid foramen. 1 Thus, the expression Bell palsy is not exclusively synonomous with idiopathic facial paralysis.
"ACTINIC RETICULOID": A CHRONIC DKHMATOSIS ASSOCIATED WITH SEVERE PHOTOSENSITIVITY AND THE HISTOLOGICAL RESEMBLANCE TO LYMPHOMA
Authors: F. A. IVE, I. A. MAGNUS, R. P. WARTN, E. WILSON JONES
Journal: British Journal of Dermatology (1969)

SUMMARY.— Ten elderly male patients with severe persistent photosensitivity of unknown cause are described. The clinical presentation was that of an intense eczematous eruption affecting exposed sites but spreading elsewhere. Frequent episodes of erythroderma were characteristic and in some cases the marked thickening and ridging of the exposed skin simulated a lymphoma. In contrast to most other photodermatoses the photosensitivity extended through the u.v. to the visible spectrum. A wide range of histological changes were noted, in several instances closely resembling lymphoma because of the intensity and pleomorphism of the infiltrate.
Recombinant gamma interferon and in vivo induction of HLA-DR antigens
Authors: B. VOLC-PLATZER, A. STEINER, TH. RADASZKIEWICZ, K. WOLFF
Journal: British Journal of Dermatology (1988)

Recombinant human IFN-gamma, used for treatment of melanoma and renal carcinoma, was found to induce HLA-DR expression on human keratinocytes in vivo. HLA-DR antigens bound to keratinocytes of the basal and suprabasal layers of the epidermis were observed after intramuscular or intravenous injections of 0.5 mg/kg body weight IFN-gamma, 3 times a week. Keratinocyte-bound HLA-DR antigens were first observed at the beginning of the third or fourth week of treatment, but HLA-DQ and HLA-DP antigens were never detected on keratinocytes. The intracytoplasmic constant (gamma) chain of the class II molecules was also not detectable within the keratinocytes. Patients who received IFN-alpha 2 therapy, did not exhibit keratinocyte-bound HLA-DR antigens.
Safe From Trachoma
Authors: Rebecca Voelker
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Isoproterenol, Asthma, and the Heart
Authors: MARK R. STEIN
Journal: Annals of Internal Medicine (1975)

Comments1 December 1975Isoproterenol, Asthma, and the HeartMARK R. STEIN, M.D., SHELDON L. SPECTOR, M.D., F.A.C.P.MARK R. STEIN, M.D.Search for more papers by this author, SHELDON L. SPECTOR, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-6-908_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent paper by Shim and Williams, "Cardiac Response to Repeated Doses of Isoproterenol Aerosol" (Ann Intern Med82:208-211, 1975), suggests that the frequent administration of aerosolized isoproterenol has no harmful effects in asthmatics. We wonder if this suggestion is justified by their data. Regarding patient selection, the designation of "moderate-to-severe asthma" based on the patient'ssubjectiveassessment of himself is not in keeping with the clinical data and is not the usual way of categorizing severity. Patients 4, 5, and 10 were on no corticosteroids and Patients 7, 8, and 13 were on no medications at...References1. GAZIOGLUCONDEMIHYDE KJR: Effect of isoproterenol on gas exchange during air and oxygen breathing in patients with asthma. Am J Med 50:185-190, 1971 CrossrefMedlineGoogle Scholar2. HARRIS W: Toxic effects of aerosol propellants on the heart. Arch Intern Med 131:162-166, 1973 CrossrefMedlineGoogle Scholar3. REISMAN R: Asthma induced by adrenergic aerosols. J Allergy 46:162-177, 1970 CrossrefMedlineGoogle Scholar4. SPECTOR S: Idiosyncratic Bronchoconstriction Following Isoproterenol (abstract). Proceedings of the World Congress on Asthma Bronchitis & Conditions Allied, New Delhi, India, November 9-15, 1974, in press Google Scholar5. PATERSONCONOLLYDAVIES JMD: Isoprenaline resistance and the use of pressurized aerosols in asthma. Lancet 2:426-429, 1968 CrossrefMedlineGoogle Scholar1. SCHERSHIMWILLIAMS SCM: Effect of bronchodilator agents on arrhythmia (abstract), ATS/CTS Annual Meeting, Montreal, Canada, May 1975 Google Scholar2. SILVERGLADE A: Cardiac toxicity of aerosol propellants (editorial). JAMA 222:827-829, 1972 CrossrefMedlineGoogle Scholar3. MCFADDENKISERDEGROOT ERW: Acute bronchial asthma. N Engl J Med 288:221-225, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Section of Allergy and Clinical Immunology National Jewish Hospital and Research Center Denver, Colorado 80206 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySudden death from asthmaAssociation between asthma mortality and isoproterenol aerosols: A review 1 December 1975Volume 83, Issue 6Page: 908-909KeywordsAsthmaHeartIsoproterenol Issue Published: 1 December 1975 PDF DownloadLoading ...
Umbilical Cord Glycosylated Hemoglobin in Infants of Diabetic Mothers: Relationships to Neonatal Hypoglycemia, Macrosomia, and Cord Serum C-Peptide
Authors: Jay M Sosenko, John L Kitzmiller, Rudolf Fluckiger, Sherry W H Loo, Donna M Younger, Kenneth H Gabbay
Journal: Diabetes Care (1982)

Relationships of neonatal glycemia and birthweight to antecedent fetal glycemia and insulinemia have been examined in the offspring of 63 insulin-dependent diabetic and 29 nondiabetic mothers. Glycosylated hemoglobin levels in maternal and cord blood were measured by the thiobarbituric acid (TBA) colorimetric technique to estimate antecedent fetal and maternal glycemia; cord serum C-peptide was assayed to estimate fetal insulinemia. Glycosylated hemoglobin levels were significantly elevated in the diabetic mothers and their offspring as compared with controls (P &amp;lt; 0.001), and maternal and cord blood levels were highly correlated in the diabetic group (r = 0.61, P &amp;lt; 0.001). Cord serum C-peptide and glycosylated hemoglobin levels tended to be associated (r = 0.43, P &amp;lt; 0.10). Hypoglycemic infants of diabetic mothers (IDM) had significantly higher glycosylated hemoglobin levels (A443 nm/10 mg hemoglobin hemolysate) in cord blood (0.173 ± 0.009) than did IDM without hypoglycemia (0.153 ± 0.005, P &amp;lt; 0.01). Macrosomic and nonmacrosomic IDM, on the other hand, did not differ as to their glycosylated hemoglobin levels (0.162 ± 0.005 versus 0.161 ± 0.006, respectively). The occurrence of hypoglycemia was not associated with that of macrosomia (X2 = 0.24, P &amp;gt; 0.10). These data strongly suggest that neonatal hypoglycemia is the result of maternal hyperglycemia in pregnancy and consequent fetal hyperglycemia and hyperinsulinemia. However, maternal hyperglycemia in late pregnancy may not be a sufficient explanation for the development of macrosomia in IDM.
<i>The New Criminology: A Consideration of the Chemical Causation of Abnormal Behavior.</i>By Max G. Schlapp, M. D., Professor of Neuropathology at New York Post-Graduate Medical School; Director of the New York Children's Court Clinic, and Edward H. Smith, Author of "Con," "Famous Poison Mysteries," and "Mysteries of the Missing." (<i>New York: Boni and Liveright, 1928.</i>)
Authors: Karl A. Menninger
Journal: American Journal of Psychiatry (1929)
PAPILLIFEROUS CARCINOMA OF THE THYROID GLAND
Authors: B. Hughes
Journal: BMJ (1920)

THE notes of these cases illustrate the importance of early operation to secure a sucoessful issue.CASE 1. B. M., aged 32) a private A.I.F., was brought into hospital in the early hours of the morning of October 13th, 1919, cold and collapsed; he vomited some coffee-grounds fluid as he was being put to bed.He gave a history of being first taken ill with pains in the upper part of the abdomen on October 6th, and being sick once or twice.The pains came on worse two to three hours after taking food.He reported sick on October 7th, and was given a "dose of medicine."On October 8th he felt better, but vomited several times during the day, the vomiting relieving the pain in the epigastric region.He seems to have dragged about until the evening of October 12th, when he had a sudden acute pain just above the umbilicus, to the right of the middle line, and was very sick.On admission the whole abdomen was very hard and rigid, and abdominal respiratory movements were absent.There was acute tenderness above the umbilicus, distinctly greater towards the right of the middle line.There was no distension of the abdomen.Liver dullness was absent.He was prepared for operation, and as soon as possible laparotomy was performed tbrough the right rectus musle.Immediately on opening the peritoneum gas escaped, as well a a certain amount of bile-stained fluid.The perforation was soon found in the first part of the duodenum, on its anterior