tbuckley/cabot-search huggingface dataset:
ANAEROBIC GLYCOLYSIS OF THE BRAIN IN EXPERIMENTAL POLIOMYELITIS
Authors: Harland G. Wood, Irving I. Rusoff, John M. Reiner
Journal: The Journal of Experimental Medicine (1945)

The rate of anaerobic glycolysis of brain tissue was compared for normal animals and animals with experimentally induced poliomyelitis, using two different strains of mice and two different procedures. The report of interference of poliomyelitis with anaerobic glycolysis of brain was not confirmed. In one series there was a small increase and in the other series a small decrease in the brain Q(CO(CO2) ) (N(2) ) calculated for infected animals as compared to normal animals. When the calculations were made on the basis of wet weight of brain there was no difference in glycolysis. It is considered that the methods so far used for study of the enzymes may be inadequate, and that no decision is as yet possible on the effect of poliomyelitis on anaerobic glycolysis.
Experimental drug that injured UK volunteers resumes in human trials
Authors: O. Dyer
Journal: BMJ (2015)

A phase II trial of an experimental drug that made headlines nine years ago when it caused horrific injuries to volunteers in a London trial is about to begin in Russia to evaluate it as a potential treatment for rheumatoid arthritis.

The drug, known as TGN1412, attained brief worldwide notoriety when six paid volunteers, all young men, were admitted to hospital for intensive care soon after being given what was believed to be a minute dose by a contract research organisation in Northwick Park Hospital, London.1 The men experienced a cytokine storm, an extreme autoimmune reaction leading to multiple organ failure. One lost his fingertips and toes to necrosis. …
Endothelial ERK signaling controls lymphatic fate specification
Authors: Yong Deng, Deepak Atri, Anne Eichmann, Michael Simons
Journal: Journal of Clinical Investigation (2013)

Lymphatic vessels are thought to arise from PROX1-positive endothelial cells (ECs) in the cardinal vein in response to induction of SOX18 expression; however, the molecular event responsible for increased SOX18 expression has not been established. We generated mice with endothelial-specific, inducible expression of an RAF1 gene with a gain-of-function mutation (RAF1S259A) that is associated with Noonan syndrome. Expression of mutant RAF1S259A in ECs activated ERK and induced SOX18 and PROX1 expression, leading to increased commitment of venous ECs to the lymphatic fate. Excessive production of lymphatic ECs resulted in lymphangiectasia that was highly reminiscent of abnormal lymphatics seen in Noonan syndrome and similar "RASopathies." Inhibition of ERK signaling during development abrogated the lymphatic differentiation program and rescued the lymphatic phenotypes induced by expression of RAF1S259A. These data suggest that ERK activation plays a key role in lymphatic EC fate specification and that excessive ERK activation is the basis of lymphatic abnormalities seen in Noonan syndrome and related diseases.
The Effect of Clomiphene Citrate in Anosmic Hypogonadotrophism
Authors: ROBERT M. BOYAR
Journal: Annals of Internal Medicine (1969)

A patient with anosmic hypogonadotrophism was treated with clomiphene citrate for 32 days. During the treatment period plasma follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were measured daily for 6 days and again at the end of 32 days. A definite increase in the concentration of plasma LH and FSH was shown at the end of the treatment period. This response was equivocal at the end of the first week of therapy. It appears that this patient is capable of synthesizing and releasing LH and FSH after treatment with clomiphene citrate. This response places the defect responsible for his hypogonadotrophic state above the level of the pituitary. It also suggests that long-term clomiphene citrate therapy may be capable of stimulating puberty in this patient as well as others with hypogonadotrophic states in whom clomiphene responsiveness is documented.
TCT-251 ECG Findings in ST-Elevation Myocardial Infarction from Culprit Left Main Coronary Artery Disease: A Multicenter Registry Study
Authors: Gagan D. Singh, Ezra A. Amsterdam, Ehrin J. Armstrong, Gregory Barsness, Krystal Chan, Jenn R. Chiam, Kelvin Chua, Koh C. Hou, Reginald Low, Ehtisham Mahmud, James M. McCabe, Marin Nishimura, Jason H. Rogers, Kendrick Shunk, Stephen Waldo, Jonathan Yap, Khung Keong Yeo
Journal: Journal of the American College of Cardiology (2013)
Accuracy of hospital activity analysis data in estimating the incidence of proximal femoral fracture.
Authors: J L Rees
Journal: BMJ (1982)

The accuracy of operation codes on hospital activity analysis printouts has been compared with unit and patient records.Inaccurate information is being provided by the hospital activity analysis in a significant number of cases.The same mistake is often repeatedly made, suggesting deficient monitoring procedures.These lapses occurred despite a unit policy of medical staff entering the operation and diagnostic details on the HMRI(IP) sheet and the checking of all entries by a consultant.
Medical Education in Post-Katrina New Orleans
Authors: N. Kevin Krane, Richard P. DiCarlo, Marc J. Kahn
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pecked to death by (flying) ducks: court decision may extinguish smoking on aircraft
Authors: S. Chapman
Journal: BMJ (1995)

A case this month in the Australian court may force Australia's national airline, Qantas, to make all its flights non-smoking now rather than next year and in the meantime offers hope of compensation to Australian passengers who are refused non-smoking seats. Mrs Leone Cameron brought a case against Qantas for seating her in the smoking section of a Sydney to Bangkok fight after she had booked a non-smoking seat. She subsequently suffered minor illnesses. She and nine other similarly affected passengers claimed that Qantas had misled them. The judged ruled that Qantas had misled passengers in five of the cases though he refused to rule that Qantas had misled those placed in non-smoking seats next to the smoking area. He also refused to order Qantas to make all its flights non-smoking. The ruling is important for enabling other passengers to seek compensation through consumer claims tribunals when refused a requested non-smoking seat. It also brings closer the day when smoking will be forbidden on all flights.
Antimicrobial Resistance
Authors: Elizabeth A. Bancroft
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Incidence of myocardial infarction in elderly men being treated with antihypertensive drugs: population based cohort study
Authors: J. Merlo, J. Ranstam, H. Liedholm, B. Hedblad, G. Lindberg, U. Lindblad, S.-O. Isacsson, A. Melander, L. Rastam
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objective</b>: To analyse the association between use of antihypertensive treatment, diastolic blood pressure, and long term incidence of ischaemic cardiac events in elderly men. <b>Design</b>: Population based cohort study. Baseline examination in 1982-3 and follow up for up to 10 years. <b>Setting</b>: Malmo, Sweden. <b>Subjects</b>: 484 randomly selected men born in 1914 and living in Malmo during 1982. <b>Main outcome measures</b>: Observational comparisons of incidence rates and rate and hazard ratios of ischaemic cardiac events (myocardial infarction or death due to chronic ischaemic cardiac disease). <b>Results</b>: The crude incidence rate of ischaemic cardiac events was higher in those subjects who were taking antihypertensive drugs than in those who were not (rate ratio 2.6 (95% confidence interval 1.7 to 3.9)). After adjustment for potential confounders (differences in baseline smoking habits, blood pressure, time since diagnosis of hypertension, ischaemic or other cardiovascular disease, hypercholesterolaemia, hypertriglyceridaemia, diabetes mellitus, obesity, and raised serum creatinine concentration) this rate was reduced but still raised (hazard ratio 1.9 (1.0 to 3.7)). In men with diastolic blood pressure &gt;90 mm Hg, antihypertensive treatment was associated with a twofold increase in the incidence of ischaemic cardiac events (rate ratio 2.0 (1.1 to 3.6)), which vanished after adjustment for potential confounders (hazard ratio 1.1 (0.5 to 2.6)). In those subjects with diastolic blood pressure &lt;/=90 mm Hg, antihypertensive treatment was associated with fourfold increase in incidence (rate ratio 3.9 (2.1 to 7.1)), which remained after adjustment for potential confounders (hazard ratio 3.8 (1.3 to 11.0)). <b>Conclusion</b>: Antihypertensive treatment may increase the risk of myocardial infarction in elderly men with treated diastolic blood pressures &lt;/=90 mm Hg.
Premalignant alterations in the lipid composition and fluidity of colonic brush border membranes of rats administered 1,2 dimethylhydrazine.
Authors: T A Brasitus, P K Dudeja, R Dahiya
Journal: Journal of Clinical Investigation (1986)

Dimethylhydrazine (DMH) is a potent procarcinogen with selectivity for the colon. To determine whether alterations in the lipid composition and fluidity of rat colonic brush border membranes existed before the development of DMH-induced colon cancer, rats were injected s.c. with this agent (20 mg/kg body weight per wk) or diluent for 5, 10, and 15 wk. Animals were killed at these time periods and brush border membranes were prepared from proximal and distal colonocytes of each group. The "static" and "dynamic" components of fluidity of each membrane were then assessed, by steady-state fluorescence polarization techniques using limiting hindered fluorescence anisotropy and order parameter values of the fluorophore 1,6 diphenyl-1,3,5-hexatriene (DPH) and fluorescence anisotropy values of DL-2-(9-anthroyl) stearic acid and DL-12-(9-anthroyl) stearic acid, respectively. Membrane lipids were extracted and analyzed by thin-layer chromatography and gas-liquid chromatography. Phospholipid methylation activity in these membranes was also measured using S-adenosyl-L-methionine as the methyl donor. The results of these studies demonstrate that: the lipid composition and both components of fluidity of proximal DMH-treated and control membranes and their liposomes were similar at all time periods examined; at 5, 10, and 15 wk the "dynamic component of fluidity" of distal DMH-treated membranes and their liposomes was found to be higher, similar, and lower, respectively, than their control counterparts; the "static component of fluidity" of distal DMH-treated membranes and their liposomes, however, was similar to control preparations at all three time periods; and alterations in the lipid composition and phospholipid methylation activities appeared to be responsible for these differences in the "dynamic component of fluidity" at these various time periods.
A controlled trial of house dust mite eradication using natamycin in homes of patients with atopic dermatitis: effect on clinical status and mite populations
Authors: M.J. COLLOFF, ROSEMARY S. LEVER, C. McSHARRY
Journal: British Journal of Dermatology (1989)

Journal Article A controlled trial of house dust mite eradication using natamycin in homes of patients with atopic dermatitis: effect on clinical status and mite populations Get access M.J. COLLOFF, M.J. COLLOFF Department of Zoology, University of Glasgow, U.K. Dr M.J.Colloff, Department of Zoology, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. Search for other works by this author on: Oxford Academic Google Scholar ROSEMARY S. LEVER, ROSEMARY S. LEVER Department of Dermatology, Western Infirmary, Glasgow, U.K. Search for other works by this author on: Oxford Academic Google Scholar C. McSHARRY C. McSHARRY Department of Bacteriology and Immunology, Western Infirmary, Glasgow, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 121, Issue 2, 1 August 1989, Pages 199–208, https://doi.org/10.1111/j.1365-2133.1989.tb01799.x Published: 01 August 1989
Myasthenia Gravis and Scleroderma
Authors: Glenn W. Mitchell
Journal: JAMA (1975)

MYASTHENIA gravis and scleroderma occasionally are found in association with other diseases but rarely in association with each other.<sup>1</sup>The following case illustrates this extremely rare combination. <h3>Report of a Case</h3> A 45-year-old woman was in good health until 1969, when she noticed that her hands became cold and cyanotic whenever she held cold objects. She soon became aware that she was unable to close her hands fully, the skin of her fingers was taking on a shiny appearance, and her face was becoming expressionless and mask-like. During and after 1972, the patient's successive complaints included stiffness and pain in all of the joints of the upper and lower extremities, progressive weakness, inability to open jars or reach into cupboards, and difficulty in climbing stairs or rising from a chair. She could not get back on her feet if she fell down. Six months before admission, results of an
PROGNOSTIC SIGNIFICANCE OF CARDIAC TROPONIN AT PRESENTATION, PEAK CARDIAC TROPONIN AND B-TYPE NATRIURETIC PEPTIDE IN PATIENTS WITH NSTEMI
Authors: Georgios Lazaros, Dimitris Tousoulis, Gerasimos Siasos, Evangelos Oikonomou, Konstantinos Maniatis, Marina Zaromitidou, Stamatios Kioufis, Eleni Kokkou, Nikolaos Papageorgiou, Manolis Vavuranakis, Charalambos Vlachopoulos, Christina Kollia, Dimitrios Athanasiou, Athanasios Papavassiliou, Christodoulos I Stefanadis
Journal: Journal of the American College of Cardiology (2013)
Hair Loss After Routine Immunizations
Authors: Robert P. Wise
Journal: JAMA (1997)

<h3>Context.</h3> —Alopecia is a recognized adverse effect of numerous medications, but vaccines are not normally considered a cause for unexpected loss of hair. <h3>Objective.</h3> —To describe case reports of hair loss after routine vaccines and to assess the hypothesis that vaccinations might induce hair loss. <h3>Design.</h3> —Case series with telephone follow-up. <h3>Methods.</h3> —Review of spontaneous reports to the Food and Drug Administration, the Centers for Disease Control and Prevention, and the Vaccine Adverse Event Reporting System. <h3>Main Outcome Measure.</h3> —Loss of hair following immunization. <h3>Results.</h3> —A total of 60 evaluable reports submitted since 1984 and coded for "alopecia" after immunizations included 16 with positive rechallenge (hair loss after vaccination on more than 1 occasion), 4 of which were definite and 12 possible or probable. Of the 60 cases, 46 had received hepatitis B vaccines. Both of the currently available recombinant products, as well as the former plasma-derived product, were represented. Females predominated in all age groups. The majority of patients recovered, but clinical features, such as intervals from vaccination until onset and the extent and reversibility of hair loss, varied widely. Nine patients reported previous medication allergy. <h3>Conclusion.</h3> —There may be an association, probably very rare, between vaccinations and hair loss. More than 1 pathophysiologic mechanism may be responsible. Since apparently nonrandom distributions by vaccine, age, and sex could reflect biased case ascertainment, further research will be needed in defined populations with consistent case detection.
Primary Care and Health: A Cross-National Comparison
Authors: Paul N. Gorman, Maria G. Martinez
Journal: JAMA (1992)

<h3>To the Editor.</h3> —In a recent issue of<i>JAMA</i>, Starfield<sup>1</sup>concludes that the development of a nation's primary care sector is related to the health of its population. Her analysis compares seven Western nations in terms of (1) an unvalidated composite measure of primary care emphasis within each country (primary care score); (2) the ratio of popular satisfaction with a nation's health system to its per capita health expenditures (satisfaction-expense index); and (3) 12 relatively standard indicators of health in each country, such as neonatal and infant mortality, life expectancy at ages 1, 20, and 65 years, age-adjusted death rate, and the like (health indicator status). The data presented are said to show that greater emphasis on primary care is associated with higher health indicator status and health satisfaction. That the nation with the highest primary care score (the United Kingdom) had the lowest health indicator status and satisfaction-expense
A FATAL CASE OF MALTA FEVER
Authors: W. R. Tyndale
Journal: JAMA (1923)

Malta fever is endemic in herds of goats in southern Utah. In 1922, two herders in this region died of a condition said to resemble this disease. In May, 1923, the patient, W. A. S., aged 33, the state veterinarian, went to this section with Dr. L. L. Daines, the state bacteriologist, to investigate the disease in the goat herds. May 15, he handled placental tissue from an infected animal; at this time he had a small cut on one hand, which, however, healed without incident. May 27, he developed chilliness and cramping pains in the legs, and the next day fever, epigastric pain and a constant headache. A few days later an unproductive cough and general pains appeared. These symptoms, with marked insomnia, sweating and weakness, continued until June 6, when they gradually subsided The patient first consulted us for his present illness, June 9. At this time there
Hemoglobinopathies in Children
Authors: Ruth Andrea Seeler
Journal: JAMA (1980)

Dr Elias Schwartz has done a masterful job in this monograph, which surveys and synthesizes the current knowledge and theory on hemoglobinopathies. Although this book is part of a pediatric series, it contains a wealth of general information useful to the internist, generalist, and adult hematologist alike. The monograph is exceptionally well edited and reads smoothly and consistently. The book is divided into three major sections. Part 1, constituting about half of the book, is an in-depth review of the anatomy and physiology of hemoglobin at the molecular level. A 16-page table catalogues known hemoglobinopathies for ready reference and review. The chapter on methodology provides solid background information in addition to useful information on improving the separation and identification of hemoglobin variants. This reviewer found some of the morphological photographs to be overenlarged, lacking the crispness we are used to seeing via the microscope. They do, however, convey the essential
Row erupts over study of HPV vaccine in 23 000 girls in India
Authors: G. Mudur
Journal: BMJ (2012)

A study in India in which girls were being vaccinated against the human papillomavirus (HPV), which had previously attracted criticism on ethical grounds, had no justification on the grounds of public health either, a team of health researchers in the United Kingdom has said.

The researchers, from the University of London and the University of Edinburgh, said in a review of the study that India’s surveillance system for cancer and its information on the incidence of cervical cancer in the country were too patchy to justify any further roll out of the vaccine.1 

But the organisers of the study countered their criticisms by saying that the researchers had “seriously misunderstood or misrepresented” the data from the Indian cancer registry, and had belittled the threat from cervical cancer in India, despite the fact that deaths from the disease outnumbered maternal deaths. They also said that the study was completely ethical.

Two years ago, women’s groups and health activists in India had questioned the ethics and the rationale of the study, in which more than 23 000 girls aged 10-14 years in Andhra Pradesh and Gujarat were vaccinated against the human papillomavirus.2 

The study, by the international non-profit making Programme for Appropriate Technologies in Health (PATH), based in Seattle, Washington state, was approved by the Indian Council of Medical Research and implemented by state health authorities using …
Search engines increase online journal use more than open access
Authors: Susan Mayor
Journal: BMJ (2006)

The ability of internet search engines to find journal articles has considerably increased the readership of academic journals, a detailed analysis of the internet use of one particular research journal has found.

Introducing open access publishing achieved a smaller additional increase in journal use, the analysis showed.

Researchers at the Centre for Publishing at University College London used a deep log analysis, which collects “digital fingerprints” of users of specific internet sites, to track use of the online version of Nucleic Acids Research . They assessed use before and after the journal introduced an “author pays” …