Erythromycin and Cyclosporine
Authors: J. M. GRIÑO
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 September 1986Erythromycin and CyclosporineJ. M. GRIÑO, I. SABATE, A. M. CASTELAO, M. GUARDIA, D. SERON, J. ALSINAJ. M. GRIÑOSearch for more papers by this author, I. SABATESearch for more papers by this author, A. M. CASTELAOSearch for more papers by this author, M. GUARDIASearch for more papers by this author, D. SERONSearch for more papers by this author, J. ALSINASearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-3-467_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Martell and colleagues (1) have reported that acutely elevated cyclosporine levels developed in patients receiving the drug when erythromycin was added to their regimen. We present a case that shows that erythromycin reduces the clearance of cyclosporine.A 45-year-old man with a 3-year-old functioning kidney allograft, maintained with cyclosporine and prednisone, was admitted because of pneumonia in October 1985. On admission, his serum creatinine level was 241 µmol/L. He was taking 180 mg/d of cyclosporine orally (body weight, 59 kg) and 15 mg/d of prednisone orally, and his whole blood levels of cyclosporine were 500 ng/mL (radioimmunoassay)....References1. MARTELL R, HEINRICHS D, STILLER C, JENNER M, KEOWN P, and DUPRE J. The effects of erythromycin in patients treated with cyclosporine. Ann Intern Med. 1986;104:660-1. LinkGoogle Scholar2. KOZAK P, CUMMINS L, and GILLMAN S. Administration of erythromycin to patients on theophylline. J. Allergy Clin Immunol. 1977;60:149-51. CrossrefMedlineGoogle Scholar3. PFEIFER H, GREENBLATT D, and FRIEDMAN P. Effects of three antibiotics on theophylline kinetics. Clin Pharmacol Ther. 1979;26:36-40. CrossrefMedlineGoogle Scholar4. PTACHCINSKI R, CARPENTER B, BURCKART G, VENKATARAMANAN R, and ROSENTHAL J. Effect of erythromycin on cyclosporine levels. N Engl J Med. 1985;313:1416-7. CrossrefMedlineGoogle Scholar5. VENUTO C, MURRAY B, EDWARDS L, and MORSE G. Cyclosporine-erythromycin drug interaction [Abstract]. Kidney Int. 1985;29:438. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. M. GRIÑO; I. SABATE; A. M. CASTELAO; M. GUARDIA; D. SERON; J. ALSINA PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byContributions of hepatic and intestinal metabolism and P-glycoprotein to cyclosporine and tacrolimus oral drug deliveryDrug Interactions with Agents Used in Immunosuppression and Cancer ChemotherapyRecent advances in pediatric infectious disease and their impact on dermatologyPrimary Renovascular Effects of Erythromycin in the Rat: Relationship to Cyclosporine NephrotoxicityCyclosporine pharmacokinetic drug interactionsCyclosporin A (CSA) Drug InteractionsEffect of erythromycin on blood cyclosporine concentrations in kidney transplant patientsMiscellaneous antibiotics 1 September 1986Volume 105, Issue 3Page: 467-468KeywordsBloodBody weightCreatinineDrugsErythromycinKidneysPneumoniaRadioimmunoassays ePublished: 1 December 2008 Issue Published: 1 September 1986 PDF downloadLoading ...