tbuckley/cabot-search huggingface dataset:
Thalidomide in refractory haemorrhagic radiation induced proctitis
Authors: M E Craanen
Journal: Gut (2006)

indicate that an increase in Treg number and function, if present in the acute hepatitis phase of the infection, predicts a chronic evolution and persists over time.Interestingly, all patients with elevated Tregs and chronic evolution harboured genotype 1 virus, suggesting a possible influence of that subset on chronic evolution, 8 perhaps through Treg triggering.Whether the elevation in regulatory T cells reported here is just a predictor of chronic evolution of HCV infection or a promoter of HCV infection chronicity, remains to be investigated.
Prescribing Proprietaries, and Managing the Detail Man
Authors: Henry B. Hemenway
Journal: JAMA (1913)

of incurable epilepsy have been led to submit themselves to a method of therapeutic experiment wholly empiric and fraught, with jus! such dangers as our editorial indicated.Physicians otherwise conservative, through the importunities of patients aroused by these newspaper accounts, have been led to test Spangler's treatment, and it is on the basis ol such trials by competent epileptologists that, we condemned ibe method and cautioned the profession against its adoption.Dr. .Mays' letter gives the opportunity of protesting again
Abstract 5110: Activation of Wnt/β-catenin, hedgehog and androgen receptor signaling pathways in solid pseudopapillary neoplasm of pancreas.
Authors: Minhee Park, Minhyung Kim, Daehee Hwang, SangKyum Kim, Eunsung Park, Youngki Paik, Jeonhan Park, Hogeun Kim
Journal: Cancer Research (2013)

Abstract Solid pseudopapillary neoplasm (SPN), is an uncommon pancreatic tumor with distinct clinicopathologic features. Mutations in the exon 3 of β-catenin are characteristically identified in SPNs, however little is known about gene and microRNA expression characteristics. To investigate the molecular characteristics of SPNs, we analyzed mRNA and microRNA expression profiles of 14 SPNs and compared their expressions to that of 6 pancreatic ductal adenocarcinomas, 6 endocrine tumors of pancreas, and 5 non-neoplastic pancreas tissues. We demonstrated both mRNA and microRNA expression profiles completely distinguish SPNs to the other pancreatic tumors and non-neoplastic pancreas tissues. We found that Wnt/β-catenin, Hedgehog and androgen receptor signaling pathways are activated in SPNs by analyzing 1,686 genes that showed specific expression changes in SPN. We also found that 7 microRNAs were specifically down-regulated in SPNs, and miR-30a was most closely associated with the up-regulation of the genes belong to the three distinct activated pathways of SPN. We also demonstrated that genes involved in epithelial to mesenchymal transition (EMT) are up-regulated in SPNs than the other type of pancreatic tumors. SPN is characterized by increased expression of mesenchymal markers (N-cadherin, MMP9, Vercican, TIMP1) and decreased expression of epithelial markers (E-cadherin, Desmoplakin, Mucin1, Caveolin). Considering that activated Wnt/β-catenin and Hedgehog pathways are related to the activation of the genes involved in EMT, these activated signaling pathways of SPNs can explain lack of epithelial cell differentiation, and the molecular mechanism of SPN tumorigenesis. Citation Format: Minhee Park, Minhyung Kim, Daehee Hwang, SangKyum Kim, Eunsung Park, Youngki Paik, Jeonhan Park, Hogeun Kim. Activation of Wnt/β-catenin, hedgehog and androgen receptor signaling pathways in solid pseudopapillary neoplasm of pancreas. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5110. doi:10.1158/1538-7445.AM2013-5110
Environment and Pulmonary Hypersensitivity
Authors: JORDAN N. FINK
Journal: Annals of Internal Medicine (1971)

Editorial Notes1 February 1971Environment and Pulmonary HypersensitivityJORDAN N. FINK, M.D.JORDAN N. FINK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-2-293 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe inhalation of a variety of organic dusts has been shown to result in a hypersensitivity pneumonitis in susceptible individuals. The dusts shown to lead to these disorders may either be of animal or vegetable origin. In pigeon breeder's disease or other bird handler's disease and in pituitary snuff taker's lung, the offending antigens are the foreign serum proteins contained in the inhaled materials (1). In the occupational disorders of farmer's lung, bagassosis, and mushroom worker's lung, however, the offending antigens have been shown to be derived from thermophilic actinomycetes contaminating the vegetable dust (1). In these cases the vegetable...References1. Editorial: Allergic alveolitis. Brit Med J 3:691, 1967 CrossrefMedlineGoogle Scholar2. BANASZAK E, THIEDE W, and FINK J: Hypersensitivity pneumonitis due to contamination of an air conditioner. New Eng J Med 283:271-276, 1970 CrossrefMedlineGoogle Scholar3. FINK J, SOSMAN A, and BARBORIAK J: Pigeon breeders' disease. A clinical study of a hypersensitivity pneumonitis. Ann Intern Med 68:1205-1219, 1968 LinkGoogle Scholar4. BUTIKOFER E and DE WECK A: Poultry keepers lung. German Med Monthly 15:245-253, 1970 Google Scholar5. ELMAN A, TEBO T, and FINK J: Reactions of poultry farmers against chicken antigens. Arch Environ Health (Chicago) 17:98-100, 1968 CrossrefMedlineGoogle Scholar6. KORN D, FLORMAN A, and GRIBETS I: Recurrent pneumonitis with hypersensitivity to hen litter. JAMA 205:44-45, 1968 CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JORDAN N. FINK, M.D.Affiliations: Medical College of Wisconsin Milwaukee, Wis. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAcute Toxic InhalationsExtrinsic allergic alveolitis 1 February 1971Volume 74, Issue 2Page: 293-294KeywordsAntigensDustHypersensitivityInhalationLungsPneumoconiosesPneumonitisSerum proteins ePublished: 1 December 2008 Issue Published: 1 February 1971 PDF downloadLoading ...
Gene Expression Profiling of Desmoid Tumors by cDNA Microarrays and Correlation with Progression-Free Survival
Authors: Sébastien Salas, Celine Brulard, Philippe Terrier, Dominique Ranchere-Vince, Agnes Neuville, Louis Guillou, Marick Lae, Agnes Leroux, Olivier Verola, Kurtz Jean-Emmanuel, Sylvie Bonvalot, Jean-Yves Blay, Axel Le Cesne, Alain Aurias, Jean-Michel Coindre, Frederic Chibon
Journal: Clinical Cancer Research (2015)

Abstract Purpose: Because desmoid tumors exhibit an unpredictable clinical course, translational research is crucial to identify the predictive factors of progression in addition to the clinical parameters. The main issue is to detect patients who are at a higher risk of progression. The aim of this work was to identify molecular markers that can predict progression-free survival (PFS). Experimental Design: Gene-expression screening was conducted on 115 available independent untreated primary desmoid tumors using cDNA microarray. We established a prognostic gene-expression signature composed of 36 genes. To test robustness, we randomly generated 1,000 36-gene signatures and compared their outcome association to our define 36-genes molecular signature and we calculated positive predictive value (PPV) and negative predictive value (NPV). Results: Multivariate analysis showed that our molecular signature had a significant impact on PFS while no clinical factor had any prognostic value. Among the 1,000 random signatures generated, 56.7% were significant and none was more significant than our 36-gene molecular signature. PPV and NPV were high (75.58% and 81.82%, respectively). Finally, the top two genes downregulated in no-recurrence were FECH and STOML2 and the top gene upregulated in no-recurrence was TRIP6. Conclusions: By analyzing expression profiles, we have identified a gene-expression signature that is able to predict PFS. This tool may be useful for prospective clinical studies. Clin Cancer Res; 21(18); 4194–200. ©2015 AACR.
Consent for mastectomy.
Authors: H J Thomson, S S Miller, S M Gore, A Bayliss
Journal: BMJ (1980)

The value of a system for reducing the number of women with breast lumps who consent unnecessarily to mastectomy was assessed. Sixty-one patients with breast lumps were divided preoperatively into three groups with benign, doubtful, and malignant lumps according to clinical, mammographic and ultrasound criteria. On the basis of these criteria written consent was requested from 29 patients for mastectomy and from 32 for only excision of the lump. Fourteen of the 29 patients who gave consent for mastectomy had carcinomas, and none of the 32 patients consenting to only lump excision. In an attempt to improve further on these results the same 61 patients were analysed retrospectively. Criteria based on age and the results of clinical examination and mammography were devised. By using these criteria only 19 women would have had to give consent for mastectomy. This new policy, which was devised to spare many women the stress of consenting unnecessarily to mastectomy, requires to be tested further in a much larger series of patients.
Thyrotropin Secretion Patterns in Health and Disease
Authors: Ferdinand Roelfsema, Johannes D. Veldhuis
Journal: Endocrine Reviews (2013)

Thyroid hormones are extremely important for metabolism, development, and growth during the lifetime. The hypothalamo-pituitary-thyroid axis is precisely regulated for these purposes. Much of our knowledge of this hormonal axis is derived from experiments in animals and mutations in man. This review examines the hypothalamo-pituitary-thyroid axis particularly in relation to the regulated 24-hour serum TSH concentration profiles in physiological and pathophysiological conditions, including obesity, primary hypothyroidism, pituitary diseases, psychiatric disorders, and selected neurological diseases. Diurnal TSH rhythms can be analyzed with novel and precise techniques, eg, operator-independent deconvolution and approximate entropy. These approaches provide indirect insight in the regulatory components in pathophysiological conditions.
Active versus physiological management of third stage of labour.
Authors: R. J. Guidotti
Journal: BMJ (1989)

Breach of this standard is ipso facto malpractice.Furthermore, responsibility for professional acts rests with the actUal treatihg physician and may not be trahsferted to leiployers, government pro- gramnmes, hospital officials or commnittees, chiefs of service, comftiiWs §onets, atid the like.We have no professional dMty to any such party; our obligatlon is solely t6 out patienits.
India's health ministry is accused of damaging vaccine production
Authors: G. Mudur
Journal: BMJ (2009)

The Ministry of Health in India has undermined the country’s century old legacy of public sector vaccine production, exacerbated vaccine shortages, and jeopardised the immunisation programme, say several healthcare organisations in a complaint to the Indian Supreme Court.

A petition filed last week wants the court to revoke an order by the health ministry last year that had suspended production of vaccines at three government vaccine manufacturing plants. The ministry had said that the plants did not meet standards of good manufacturing practice.

The Central Research Institute, in Kasauli, in the northern state of Himachal Pradesh, the Pasteur Institute of India, in Coonoor, Tamil Nadu, and the Vaccine …
T lymphocyte cloning from rejected human kidney allografts. Growth frequency and functional/phenotypic analysis.
Authors: J F Moreau, M Bonneville, M A Peyrat, A Godard, Y Jacques, C Desgranges, J P Soulillou
Journal: Journal of Clinical Investigation (1986)

Mechanically harvested lymphocytes invading an irreversibly rejected human kidney allograft were seeded at limiting dilution to calculate the frequency of growing precursors. Optimal growth frequency (1/13) was obtained when Epstein-Barr virus (EBV)-transformed donor B lymphocytes were used as stimulators (D-BLCL) in the presence of interleukin 2 (IL-2). The 55 clones analyzed were all T11+ and T3+, and all expressed DR antigens (45% were T8+ and 55% T4+). Only one clone had a double-labeled (T4+ T8+) surface. All cells proliferated significantly against D-BLCL, although T4+ clones had a significantly shorter average doubling time than T8+ clones. Nearly all T8+ clones were specifically cytotoxic for D-BLCL, while both T4 and T8 did not react against K562, autologous EBV-BLCL, and third-party EBV-BLCL. Detectable IL-2 was found in the culture supernatants of only a minority of clones (all T4+).
Weight Loss Treatment in Obese Adults
Authors: Kishore M. Gadde
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Emergency Medical Services— The Bottom Line
Authors: Terrence S. Carden
Journal: JAMA (1979)

As emergency medical systems have developed in recent years, they have functioned under a number of presumptions. Chief among these is the conviction that the time, work, and money involved in the development of such systems reap tangible benefits for society in terms of lives saved and prolonged. It has also been presumed by those active in the field that the effectiveness of emergency medical services (EMSs) is directly related to the speed with which such services can be provided in times of crisis. Such a presumption is only the logical extension of battlefield experience, which proved that rapid stabilization of the conditions of severely wounded patients before evacuation for definitive care resulted in notable decreases in morbidity and mortality. When physicians used to such sophisticated battlefield intervention began returning from Vietnam to practice in their native country, they found relatively primitive emergency-response systems. Ambulance attendants required less formal training
Hemoglobin Level, Chronic Kidney Disease, and the Risks of Death and Hospitalization in Adults With Chronic Heart Failure
Authors: Alan S. Go, Jingrong Yang, Lynn M. Ackerson, Krista Lepper, Sean Robbins, Barry M. Massie, Michael G. Shlipak
Journal: Circulation (2006)

Background— Previous studies have associated reduced hemoglobin levels with increased adverse events in heart failure. It is unclear, however, whether this relation is explained by underlying kidney disease, treatment differences, or associated comorbidity. Methods and Results— We examined the associations between hemoglobin level, kidney function, and risks of death and hospitalization in persons with chronic heart failure between 1996 and 2002 within a large, integrated, healthcare delivery system in northern California. Longitudinal outpatient hemoglobin and creatinine levels and clinical and treatment characteristics were obtained from health plan records. Glomerular filtration rate (GFR; mL · min −1 · 1.73 m −2 ) was estimated from the Modification of Diet in Renal Disease equation. Mortality data were obtained from state death files; heart failure admissions were identified by primary discharge diagnoses. Among 59 772 adults with heart failure, the mean age was 72 years and 46% were women. Compared with that for hemoglobin levels of 13.0 to 13.9 g/dL, the multivariable-adjusted risk of death increased with lower hemoglobin levels: an adjusted hazard ratio (HR) of 1.16 and 95% confidence interval (CI) of 1.11 to 1.21 for hemoglobin levels of 12.0 to 12.9 g/dL; HR, 1.50 and 95% CI, 1.44 to 1.57 for 11.0 to 11.9 g/dL; HR, 1.89 and 95% CI, 1.80 to 1.98 for 10.0 to 10.9; HR, 2.31 and 95% CI, 2.18 to 2.45 for 9.0 to 9.9; and HR, 3.48 and 95% CI, 3.25 to 3.73 for &lt;9.0 g/dL. Hemoglobin levels ≥17.0 g/dL were associated with an increased risk of death (adjusted HR, 1.42; 95% CI, 1.24 to 1.63). Compared with those with a GFR ≥60 mL · min −1 · 1.73 m −2 , persons with a GFR &lt;45 mL · min −1 · 1.73 m −2 had an increased mortality risk: adjusted HR, 1.39 and 95% CI, 1.34 to 1.44 for 30 to 44; HR, 2.28 and 95% CI, 2.19 to 2.39 for 15 to 29; HR, 3.26 and 95% CI, 3.05 to 3.49 for &lt;15; and HR, 2.44 and 95% CI, 2.28 to 2.61 for those on dialysis. Relations were similar for the risk of hospitalization. The findings did not differ among patients with preserved or reduced systolic function, and hemoglobin level was an independent predictor of outcomes at all levels of kidney function. Conclusions— Very high (≥17 g/dL) or reduced (&lt;13 g/dL) hemoglobin levels and chronic kidney disease independently predict substantially increased risks of death and hospitalization in heart failure, regardless of the level of systolic function. Randomized trials are needed to evaluate whether raising hemoglobin levels can improve outcomes in chronic heart failure.
MicroRNA-135a contributes to the development of portal vein tumor thrombus by promoting metastasis in hepatocellular carcinoma
Authors: Shupeng Liu, Weixing Guo, Jie Shi, Nan Li, Xiya Yu, Jie Xue, Xiaohui Fu, Kaijian Chu, Chongde Lu, Jiangsha Zhao, Dong Xie, Mengchao Wu, Shuqun Cheng, Shanrong Liu
Journal: Journal of Hepatology (2011)
Comprehensive Evaluation of Cardiac Pacemakers.
Authors: Ronald S. Pennock
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Comprehensive Evaluation of Cardiac Pacemakers.Ronald S. Pennock, M.D., Leonard S. Dreifus, M.D., Yoshio Watanabe, M.D., Dryden Morse, M.D.Ronald S. Pennock, M.D.Search for more papers by this author, Leonard S. Dreifus, M.D.Search for more papers by this author, Yoshio Watanabe, M.D.Search for more papers by this author, Dryden Morse, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-820_6 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt present, permanent cardiac pacemakers are electively replaced after 18 months. Some generators have failed earlier, and thus far no foolproof system can predict impending failure. A new system was developed to monitor the pulse interval to ±0.1 msec, utilizing the electronic R-R signal that is transmitted over ordinary telephone lines by a data coupler to the pacemaker clinic. After pacemaker implantation a base line is established over a 3-week period. The unit is tested monthly for 1 year. Pacemakers with an interval drift of more than ±20 msec in 1 month are then tested weekly until predicted failure (±15... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 820-821KeywordsHeart ratePacemakers Issue Published: 1 May 1971 PDF DownloadLoading ...
SYNOPSIS OF OPIUM INEBRIETY; EFFECT, NEEDED LEGISLATION, DISTINCTIVE PLANS OF TREATMENT NECESSARY FOR THE SUCCESSFUL CURE.Read before the Section of Medical Jurisprudence and Neurology, at the Forty-second Annual Meeting of the American Medical Association, held at Washington, D. C., May, 1891.
Authors: W. S. WATSON
Journal: JAMA (1891)

Member of the American Association for the Study and Cure of Inebriety, of the Ninth International Medical Congress, of the American Medical Association, Dutchess County Medical Association. He who has proven himself an attentive observer of the transactions of man for the past twenty-five years, does not hesitate to pronounce the last quarter of the transpired portion of the nineteenth century the most remarkable in the history of man. The philosopher, the scholar and the philanthropist, will be ready to declare that at no period, in all former times, have the intellectual energies of our race made so momentous discoveries, or put forth such exalted plans of benevolence for the benefit of mankind. The mighty achievements in the mechanical world have given new impetus to old powers and created new ones of vast results, profitable to us as a nation and as individuals. Revelations in language, in inscriptions, in customs
Comparisons of estimated human body burdens of dioxinlike chemicals and TCDD body burdens in experimentally exposed animals.
Authors: M J DeVito, L S Birnbaum, W H Farland, T A Gasiewicz
Journal: Environmental Health Perspectives (1995)

Humans are exposed to mixtures of polyhalogenated aromatic hydrocarbons, and the potential health effects of these exposures are uncertain. A subset of this class of compounds produce similar spectra of toxicity in experimental animals as does 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and these chemicals have been classified as
Health Problems of Hepatitis
Authors: Michael Scott
Journal: JAMA (1965)

To the Editor:—  The US Public Health Service reported 41,385 cases of infectious and serum hepatitis during 1964. 1 This statistic establishes infectious and serum hepatitis together as the third most common notifiable infectious disease. No one knows how many thousands of patients contract the difficult-to-diagnose anicteric form. Little is known concerning the virus. There is no specific treatment. The illness is lengthy, the convalescence longer. We are often unaware of the severe financial loss to the family; the national loss also must be great.  The medical profession should concentrate on prevention and research to identify the causative agent and develop inexpensive screening tests to detect carriers and aid early diagnosis. Prevention is possible now if we use our existing knowledge. It is generally agreed that infectious hepatitis is spread by polluted water. Our inland waters are being made unsafe by some owners of boats and summer homes, who see