Blindness and Vincristine
Authors: ABDALLA S. AWIDI
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 November 1980Blindness and VincristineABDALLA S. AWIDI, M.D.ABDALLA S. AWIDI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-5-781_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Since vinca alkaloids were introduced for clinical use, several side effects associated with vincristine therapy have been reported; neurotoxicity is the most frequent of these. Although optic atrophy has been reported (1), there is no previous record of bilateral optic atrophy and blindness in humans. I wish to report such a complication.An 18-year-old man presented with a 3-week history of general malaise, night sweats, anorexia, and cervical swellings. He was found to have generalized lymphadenopathy, marked hepatosplenomegaly, and right lower lobe pneumonia. A lymph node biopsy showed poorly differentiated diffuse lymphocytic lymphoma.The patient was started...References1. SANDERSON P, KUWABARA T, and COGAN D. Optic neuropathy presumably caused by vincristine therapy. Am J Ophthalmol. 1976;81:146-50. CrossrefMedlineGoogle Scholar2. WEISS H, WALKER M, and WIERNIK P. Neurotoxicity of commonly used antineoplastic agents. N Engl J Med. 1974;291:127-33. CrossrefMedlineGoogle Scholar3. HOLLAND J, SCHARLAU C, and GAILANI S. Vincristine treatment of advanced cancer: a cooperative study of 392 cases. Cancer Res. 1973;33:1258-64. MedlineGoogle Scholar4. ROBERTSON G, BHOOPALAM N, and ZELKOWITZ L. Vincristine neurotoxicity and abnormal secretion of antidiuretic hormone. Arch Intern Med. 1973;132:717-20. CrossrefMedlineGoogle Scholar5. ROSENTHAL S and KANFONAM S. Vincristine neurotoxicity. Ann Intern Med. 1974;80:733-7. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ABDALLA S. AWIDI, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEvaluation of diplopia as a vital and remarkable ocular finding among cancer patientsOncolytic DrugsEye Symptoms and Toxicities of Systemic ChemotherapyOptic neuropathy in the context of leukemia or lymphoma: diagnostic approach to a neuro-oncologic emergencyVinca alkaloidsDrug-induced ocular side effectsEye Symptoms and Toxicities of Systemic ChemotherapyDRUGS USED IN CANCER CHEMOTHERAPYDrug-induced ocular side effectsVinca alkaloidsUpdate on Ocular Complications of Systemic Cancer ChemotherapyChemotherapeutische Nebenwirkungen im AugenbereichCytostatic drugsOcular toxicity and cancer chemotherapy: A reviewOptic nerve head infiltration in acute leukemia in children: An indication for emergency optic nerve radiation therapyClinical Neurotoxic Concerns on Antineoplastic AgentsVisual hallucinations following treatment with vincristineA prospective cohort study of the orofacial effects of vincristine neurotoxicityOcular complications of systemic cancer chemotherapyVincristine-induced changes in the retina of the isolated arterially-perfused cat eyeSudden onset of blindness in patients treated with oral CCNU and low-dose cranial irradiationVincristine NeurotoxicityThe Cellular Basis of Visual Dysfunction in Hereditary Retinal DisordersTransient Optic Neuropathy Secondary to Mopp Chemotherapy in Hodgkin's Disease: Report of a CaseCranial nerve palsies in metastatic breast cancer due to osseous metastasis without intracranial involvementOcular Toxicity of Antineoplastic AgentsCytostatic and immunosuppressive drugs 1 November 1980Volume 93, Issue 5 Page: 781-781 Keywords Alkaloids Atrophy Biopsy Blindness Hepatosplenomegaly Inflammation Lymph nodes Lymphoma Pneumonia Sweat ePublished: 1 December 2008 Issue Published: 1 November 1980 PDF downloadLoading ...