tbuckley/cabot-search huggingface dataset:
Intraindividual genome expression analysis reveals a specific molecular signature of psoriasis and eczema
Authors: Maria Quaranta, Bettina Knapp, Natalie Garzorz, Martina Mattii, Venu Pullabhatla, Davide Pennino, Christian Andres, Claudia Traidl-Hoffmann, Andrea Cavani, Fabian J. Theis, Johannes Ring, Carsten B. Schmidt-Weber, Stefanie Eyerich, Kilian Eyerich
Journal: Science Translational Medicine (2014)

Signatures from patients with both psoriasis and eczema contribute to understanding disease pathogenesis and diagnosis.
Tamoxifen-Induced Endometrial Polyp
Authors: D Timmerman, I Vergote
Journal: New England Journal of Medicine (1996)

Figure 1. A 76-year-old woman with breast cancer who had been receiving adjuvant therapy with tamoxifen (20 mg per day) for 30 months presented with minimal vaginal bleeding. Color Doppler imaging revealed multiple arterial vessels with a very low resistance to flow (pulsatility index, 0.50; resistance index, 0.37) within the endometrium. The presence of a large endometrial polyp was demonstrated by the intrauterine instillation of sterile saline under ultrasonographic control (Panel A). Except for the large floating polyp (P), the endometrium (arrows) was thin and regular. M denotes the surrounding myometrium. The hysteroscopic view of the polyp, which measured 5.5 . . .
1100 REGULATION OF RADIATION INDUCED LIVER CANCER STEM CELL MIGRATION AND METASTASIS BY ADAM17
Authors: S.K. Yoon, S.W. Hong, W. Hur, Y.K. Lee, S.W. Choi, S.H. Cho, J.M. Yang, Y.S. Lee, C.D. Lee
Journal: Journal of Hepatology (2013)
Peginterferon alfa-2a (40 kd) and ribavirin for black American patients with chronic HCV genotype 1
Authors: Lennox J. Jeffers, William Cassidy, Charles D. Howell, Sylvia Hu, Rajender K. Reddy
Journal: Hepatology (2004)

Black Americans (blacks) have a high prevalence of chronic hepatitis C virus (HCV) infection and respond poorly to therapy with interferon alfa-based regimens, but they have been underrepresented in clinical trials. The aim of this study was to assess the rate of sustained virological response (SVR) to peginterferon alfa-2a (40 kd) in combination with ribavirin in black patients chronically infected with HCV genotype 1. In a prospective, multicenter, open-label trial, 78 black and 28 white American interferon-naïve patients were enrolled to receive once weekly subcutaneous injections of 180 microg peginterferon alfa-2a plus oral ribavirin (1000 mg/d for patients weighing less than 75 kg and 1200 mg/d for patients weighing 75 kg or more) for 48 weeks. Pre- and post-treatment liver biopsies were evaluated for necroinflammation and fibrosis. SVR, defined as undetectable (<50 IU/mL) HCV RNA, was 26% in the black group and 39% in the white group. Although the SVR rate was lower in blacks than in whites, the SVR of 26% represents an improvement over previously reported SVR rates from smaller, retrospective studies of black patients. We also observed improvement in fibrosis in 25% of the black patients. No unexpected adverse events occurred. In conclusion, this prospective study evaluating responses of black patients with chronic hepatitis C to peginterferon alfa-2a/ribavirin has demonstrated that treatment can be safely offered to such individuals with reasonable antiviral and histological benefit.
Oncolytic Adenoviruses Kill Breast Cancer Initiating CD44+CD24–/Low Cells
Authors: Minna Eriksson, Kilian Guse, Gerd Bauerschmitz, Pekka Virkkunen, Maija Tarkkanen, Minna Tanner, Tanja Hakkarainen, Anna Kanerva, Renee A Desmond, Sari Pesonen, Akseli Hemminki
Journal: Molecular Therapy (2007)

Cancer stem cells have been indicated in the initiation of tumors and are even found to be responsible for relapses after apparently curative therapies have been undertaken. In breast cancer, they may reside in the CD44(+)CD24(-/low) population. The use of oncolytic adenoviruses presents an attractive anti-tumor approach for eradication of these cells because their entry occurs through infection and they are, therefore, not susceptible to those mechanisms that commonly render stem cells resistant to many drugs. We isolated CD44(+)CD24(-/low) cells from patient pleural effusions and confirmed stem cell-like features including oct4 and sox2 expression and Hoechst 33342 exclusion. CD44(+)CD24(-/low) cells, including the Hoechst excluding subpopulation, could be effectively killed by oncolytic adenoviruses Ad5/3-Delta24 and Ad5.pk7-Delta24. In mice, CD44(+)CD24(-/low) cells formed orthotopic breast tumors but virus infection prevented tumor formation. Ad5/3-Delta24 and Ad5.pk7-Delta24 were effective against advanced orthotopic CD44(+)CD24(-/low)-derived tumors. In summary, Ad5/3-Delta24 and Ad5.pk7-Delta24 can kill CD44(+)CD24(-/low), and also committed breast cancer cells, making them promising agents for treatment of breast cancer.
Yersinia Hepatic Abscesses and Iron Overload
Authors: Claudio Chiesa
Journal: JAMA (1987)

To the Editor.—  Leighton and MacSween 1 describe the occurrence of septicemia and multiple abscesses due to Yersinia enterocolitica in a patient who had been receiving long-term iron therapy. Their report is further evidence of the remarkable susceptibility of patients with high iron stores to generalized Y enterocolitica infection.  From 1978 to 1986, in Italy, almost all cases of severe clinical disease due to Y enterocolitica developed in subjects with iron overload. In fact, eight of ten cases of Y enterocolitica septicemia occurred in patients with β-thalassemia major, while Y enterocolitica peritonitis was encountered in these patients exclusively. 2,3 All isolates belonged to human pathogenic strains ( Y enterocolitica biogroup 4, serogroup 03, phage type VIII; biogroup 2, serogroup 09, phage type X 3 ). Five patients presented with deep suppuration limited to sites in the digestive system, such as the appendix and the mesenteric lymph nodes.  It has been suggested that
Histologic Variants of Upper Tract Urothelial Carcinoma Do Not Affect Response to Adjuvant Chemotherapy After Radical Nephroureterectomy
Authors: Evanguelos Xylinas, Michael Rink, Vitaly Margulis, Pierre I. Karakiewicz, Karim Bensalah, Shahrokh F. Shariat
Journal: European Urology (2012)
Subcutaneous infection by Microsporum gypseum
Authors: B. Fernandez-Torres, E. Mayayo, J. Boronat, J. Guarro
Journal: British Journal of Dermatology (2002)

We report a case of subcutaneous infection caused by the dermatophyte Microsporum gypseum in an immunocompetent host. The patient acquired the infection in the knee through a traumatic inoculation of a splinter. To our knowledge this is the first case of subcutaneous infection caused by this fungus.
Rapid and Robust Transgenic High-Grade Glioma Mouse Models for Therapy Intervention Studies
Authors: Nienke A. de Vries, Sophia W. Bruggeman, Danielle Hulsman, Hilda I. de Vries, John Zevenhoven, Tessa Buckle, Bob C. Hamans, William P. Leenders, Jos H. Beijnen, Maarten van Lohuizen, Anton J.M. Berns, Olaf van Tellingen
Journal: Clinical Cancer Research (2010)

To develop a transgenic mouse model of glioma that can be conveniently used for testing therapy intervention strategies. High-grade glioma is a devastating and uniformly fatal disease for which better therapy is urgently needed. Typical for high-grade glioma is that glioma cells infiltrate extensively into surrounding pivotal brain structures, thereby rendering current treatments largely ineffective. Evaluation of novel therapies requires the availability of appropriate glioma mouse models.High-grade gliomas were induced by stereotactic intracranial injection of lentiviral GFAP-Cre or CMV-Cre vectors into compound LoxP-conditional mice, resulting in K-Ras(v12) expression and loss of p16(Ink4a)/p19(Arf) with or without concomitant loss of p53 or Pten.Tumors reproduced many of the features that are characteristic for human high-grade gliomas, including invasiveness and blood-brain barrier functionality. Especially, CMV-Cre injection into p53;Ink4a/Arf;K-Ras(v12) mice resulted in high-grade glioma with a short tumor latency (2-3 weeks) and full penetrance. Early detection and follow-up was accomplished by noninvasive bioluminescence imaging, and the practical utility for therapy intervention was shown in a study with temozolomide.We have developed a realistic high-grade glioma model that can be used with almost the same convenience as traditional xenograft models, thus allowing its implementation at the forefront of preclinical evaluation of new treatments.
PTEN Autoregulates Its Expression by Stabilization of p53 in a Phosphatase-Independent Manner
Authors: Yufang Tang, Charis Eng
Journal: Cancer Research (2006)

Abstract PTEN (phosphatase and tensin homologue, deleted on chromosome 10) is a tumor suppressor with dual phosphatase activity and mutations of its gene, PTEN, have been associated with many sporadic cancers and heritable neoplasia syndromes, including Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome. However, accumulating evidence now shows that PTEN may have novel functions other than as a phosphatase. In the present study, we show that PTEN is able to autoregulate its expression through the stabilization of another tumor suppressor p53. We further show that PTEN enhances p53 transactivation, a relationship that requires the interaction between PTEN and p53 and is PTEN phosphatase independent. We show that cell lines from Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome patients with germ line PTEN promoter mutations in the vicinity of the p53-binding motifs have altered p53 regulation. This seems to be due to reduced PTEN stability and decreased PTEN-p53 interactions. Our data provide clues to better understand the regulation of PTEN expression and the possible mechanisms of the pathogenesis of the subset of Cowden syndrome individuals with germ line promoter variation and who lack mutations in the PTEN coding region and splice sites. Importantly, this mechanism also holds for those sporadic tumors that lack intragenic mutations but have hemizygous deletion of PTEN, which includes the promoter region as manifested by loss-of-heterozygosity of 10q markers. The importance of our observations is underlined by the broad spectrum of neoplasias that harbor somatic PTEN or p53 alterations, or both. (Cancer Res 2006; 66(2): 736-42)
"Cured" Cases of Otitis Media-Reply
Authors: George Heller
Journal: JAMA (1966)

<h3>To the Editor:—</h3> Doctor Dunkelberger's comment seems to be more critical than factual. It would be interesting to know the exact history of the disastrous cases he refers to and to be told precisely how many are represented in the "so many" and "so much" he mentions. The studies referred to in my letter do present such data as must be studied in order that any conclusions be considered valid. Suffice to say that I know of but one permanent perforation in my practice, and that child was treated elsewhere before the family moved into our community. This has also been the experience of my pediatric colleagues. A retrospective questionnaire study (unpublished) of several hundred school children in our county showed no correlation between hearing impairment and the mode of treatment of otitis media among the children.
Ryanodine receptors: waking up from refractoriness
Authors: E. Niggli
Journal: Cardiovascular Research (2011)

This editorial refers to ‘Recovery of cardiac calcium release is controlled by sarcoplasmic reticulum refilling and ryanodine receptor sensitivity’ by H.R. Ramay et al ., pp. 598–605, this issue. 

Ca2+-induced Ca2+ release (CICR) from the sarcoplasmic reticulum (SR) via ryanodine receptors (RyRs) ultimately governs cardiac muscle force and can be considered as an amplification system for cardiac Ca2+ signals. CICR is initiated by Ca2+ influx via voltage-dependent L-type Ca2+ channels.1 Unlike skeletal muscle fibres, each cardiac myocyte can produce an amount of force (and a Ca2+ transient) that is graded by the amplitude of the Ca2+ current. How this works had remained a mystery for years because CICR is a positive feedback mechanism and one would expect, and mathematically predict, an all-or-none behaviour for these Ca2+ signals.2 As it turns out, regulation of the amplitude of the cardiac Ca2+ transients is implemented by virtue of a local control process, recruiting fewer or more Ca2+ sparks as needed to generate a small or large Ca2+ transient. Ca2+ sparks are subcellular elementary SR Ca2+ release signals, each of which is an all-or-none CICR event by itself, consistent with the predictions for a positive feedback system.

Since the discovery of Ca2+ sparks, the combined efforts of many research groups have particularized features of their activation. However, much less is known about …
Endocarditis After Acupuncture and Injection—Treatment by a Natural Healer
Authors: Olaf Scheel
Journal: JAMA (1992)

<h3>To the Editor.</h3> —Patients with prosthetic heart valves may be unaware of the risk they undergo from minor operations, such as dental procedures. Another risk is from acupuncture.<sup>1-3</sup>This treatment, often performed by natural healers, has become increasingly popular in Norway over the past two decades. I have recently seen a patient with a prosthetic heart valve who developed endocarditis.<sup>4</sup> <h3>Report of a Case.</h3> —A 59-year-old woman had prosthetic heart valves installed because of rheumatic valve disease. Two weeks before hospital admission, she had been given a 2-day treatment by a natural healer because of pains following a minor blow to her head. The treatment consisted of a series of "vi
82 KRUPPEL LIKE FACTOR 6 (KLF6) REGULATES HEAPTIC INSULIN RESISTANCE (HEP-IR)
Authors: A. Gastaldelli, D. Ciociaro, E. Buzzigoli, L. Pascoe, L. Miele, E. Bugianesi, C. Day, M. Walker, H.L. Reeves
Journal: Journal of Hepatology (2010)
Percutaneous cholecystolithotomy: the first 60 patients.
Authors: S G Chiverton, J A Inglis, C Hudd, M J Kellett, R C Russell, J E Wickham
Journal: BMJ (1990)

OBJECTIVE--To assess the feasibility and possible complications of percutaneous removal of gall stones. DESIGN--Prospective study of the first 60 patients treated. SETTING--The London Clinic. PATIENTS--60 Consecutive patients with symptomatic gall stones who agreed to have them removed percutaneously. RESULTS--56 Patients had stones successfully removed percutaneously. In four patients failure of access necessitated a cholecystectomy under the same anaesthetic. Two patients had an empyema of the gall bladder drained initially, followed by a second operation to remove the stones one week later. Seven patients had postoperative complications, and two had recurrences of biliary calculi. CONCLUSIONS--The techniques and instruments used in percutaneous nephrolithotomy can successfully be adapted for percutaneous removal of gall stones. The procedure is suitable for a wider range of patients than other techniques that leave the gall bladder intact.
Wife battering: a preliminary survey of 100 cases.
Authors: J J Gayford
Journal: BMJ (1975)

One hundred battered wives were interviewed. All had bruising, often together with other injuries, such as lacerations and fractures, There was a high incidence of violence in the family histories of both partners, and of drunkeness and previous imprisonment among the husbands. Netherless, both husbands and wives had wide range of educational achievements. Mmost wives were subjected to repeated violence because they had no alternative but to return to the marital home; There was an association between wife battering and child abuse. Places of sanctuary are needed where a woman can take her children when violence is out of control.
Linkage between smoking and asthma
Authors: A. Pietinalho, A. Pelkonen, P. Rytilä
Journal: Allergy (2009)

Smoking is one of the most important preventable public health problems. Prevalence of smoking is decreasing in the Western world but lot of work is left. We reviewed the most important papers related to smoking and asthma. Despite of decreasing smoking figures in Finland, about 15-20 per cent of pregnant women smokes. Children's exposure to harmful effects of environmental tobacco smoke (ETS) still continues. Exposure to tobacco smoke during pregnancy and in early childhood both deteriorates permanently children's lungs and increases their asthma risk. The exposure of adults to ETS also increases their asthma risk. Both passive exposure to ETS and active smoking worsen asthma. In addition, smoking asthmatics run a higher risk of developing COPD compared to non-smokers. Smoking prevalence among the population can be regulated through legislation, but the health care personnel have a central role in encouraging smoking cessation among smoking patients.
SWAP-70-like Adapter of T Cells, an Adapter Protein that Regulates Early TCR-Initiated Signaling in Th2 Lineage Cells
Authors: Yoshihiko Tanaka, Kun Bi, Rika Kitamura, Sooji Hong, Yoav Altman, Akira Matsumoto, Hiroki Tabata, Svetlana Lebedeva, Paul J Bushway, Amnon Altman
Journal: Immunity (2003)
Tuberculosis of the Vulva
Authors: J. Crossley, O. A. N. Husain
Journal: BMJ (1958)

Tuberculosis of the VulvaTuberculosis of the vulva is rare in spite of the prominence given to it in gynaecological textbooks.It was first described in 1881 (Bates and Rucker, 1944), and in 1915 Bulkley col- lected 71 cases from the literature.By 1949 Pardini found that only 100 cases had been reported, 11 of them primary lesions.According to Mathew (1949) genital tuberculosis is found in 0.2 to 2.0% of all gynaecological cases, and in 1 to 2% of these the external genitalia are involved.Symptoms of pruritus, offensive discharge, dysuria,
Retinopathy in Young-onset Diabetic Patients
Authors: Ronald Klein, Barbara E Klein, Scot E Moss, Matthew D Davis, David L DeMets
Journal: Diabetes Care (1985)

The relative importance of duration of diabetes before and after 13 yr of age as a risk factor for retinopathy was investigated using data from 200 persons who were younger than 26 yr of age. These persons were identified in a population-based study of diabetic retinopathy in southern Wisconsin in 1980–1982. Retinopathy was found in 9% of persons who were younger than 13 yr and in 34% of persons who were 13 yr or older and had been diagnosed at or after 13 yr. Presence of retinopathy was more strongly associated with the duration of diabetes after 13 yr of age than before it.
Perilipin Deficiency and Autosomal Dominant Partial Lipodystrophy
Authors: Sheetal Gandotra, Caroline Le Dour, William Bottomley, Pascale Cervera, Philippe Giral, Yves Reznik, Guillaume Charpentier, Martine Auclair, Marc Delépine, Inês Barroso, Robert K. Semple, Mark Lathrop, Olivier Lascols, Jacqueline Capeau, Stephen O'Rahilly, Jocelyne Magré, David B. Savage, Corinne Vigouroux
Journal: New England Journal of Medicine (2011)

Perilipin is the most abundant adipocyte-specific protein that coats lipid droplets, and it is required for optimal lipid incorporation and release from the droplet. We identified two heterozygous frameshift mutations in the perilipin gene (PLIN1) in three families with partial lipodystrophy, severe dyslipidemia, and insulin-resistant diabetes. Subcutaneous fat from the patients was characterized by smaller-than-normal adipocytes, macrophage infiltration, and fibrosis. In contrast to wild-type perilipin, mutant forms of the protein failed to increase triglyceride accumulation when expressed heterologously in preadipocytes. These findings define a novel dominant form of inherited lipodystrophy and highlight the serious metabolic consequences of a primary defect in the formation of lipid droplets in adipose tissue.
Why Not Scientific Administration?
Authors: George D. Lundberg
Journal: JAMA (1983)

Physicians are practitioners of the art and science of medicine. Academic and practicing medical leaders and editors insist on the best possible data prior to drawing conclusions and taking actions. In those roles, we dogmatically adhere to the great desirability of prospective, randomized, double-blind clinical trials with numbers great enough to ensure statistical power. We use anonymous referees to exert true academic rigor and expert biostatisticians to critique the experimental design, validity of data, and conclusions prior to publishing any important scientific article. Clinicians in practice, researchers, teachers, house officers, and medical students teach, are taught, and live by such critical rigor of scientific method applicable to patient care decisions. Then how is it that these same groups of people will tolerate the creation and application of laws, regulations, standards, and guidelines that have an immense impact on the practice of medicine when virtually no scientific method has been applied?
The complicated path to true causes of disease: role of nuclear factor B in inflammatory bowel disease
Authors: S Schreiber
Journal: Gut (2005)

Challenging our understanding of the role of nuclear factor κB activation in the pathophysiology of intestinal inflammation in human inflammatory bowel disease

Nuclear factor kappa B (NFκB) was discovered as a transcription factor some 15 years ago.1 Since then the protein has been linked to early pathophysiological events in a host of inflammatory conditions. NFκB, in most instances, is a heterodimer composed of a p50 and p65 subunit. In most mammalian cells NFκB is found in the resting state in the cytoplasm where it is bound in a complex to a protein that is a member of a family of specific inhibitors (IKK). Following phosphorylation, the inhibitor is rapidly degraded and the released NFκB migrates within minutes into the nucleus where it can specifically induce gene expression by binding to sequence defined DNA elements in gene promoter regions.

Even after more than a decade of mechanistic and clinical studies, the role of NFκB in intestinal inflammation is not fully …