tbuckley/cabot-search huggingface dataset:
Hyponatremia Associated with Quinupristin–Dalfopristin
Authors: Randolph P. Cole
Journal: Annals of Internal Medicine (2000)

Letters19 September 2000Hyponatremia Associated with Quinupristin–DalfopristinRandolph P. Cole, MD, W. Daniel Roberts, MS, and Matthew D. Cheng, MDRandolph P. Cole, MDColumbia University; New York, NY 10032 (Cole, Roberts, Cheng)Search for more papers by this author, W. Daniel Roberts, MSColumbia University; New York, NY 10032 (Cole, Roberts, Cheng)Search for more papers by this author, and Matthew D. Cheng, MDColumbia University; New York, NY 10032 (Cole, Roberts, Cheng)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-6-200009190-00029 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Quinupristin–dalfopristin has recently been released for treatment of infection with gram-positive organisms, such as vancomycin-resistant Enterococcus faecium. We report the development of marked hyponatremia associated with this drug.A 67-year-old woman with peripheral neuropathy, IgM paraproteinemia, and tobacco-related chronic obstructive pulmonary disease was hospitalized with dyspnea and hyponatremia. Chest radiography showed collapse of the right middle and lower lobes. Bronchoscopy revealed small-cell carcinoma occluding the bronchus intermedius. The patient received three cycles of chemotherapy with etoposide, cyclophosphamide, and adriamycin. Her hospital course was notable for three episodes of nadir sepsis, prolonged ventilator dependence, and depression (treated with ...Reference1. Kessler J, Samuels SC. Sertraline and hyponatremia [Letter]. N Engl J Med. 1996;335:524. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Columbia University; New York, NY 10032 (Cole, Roberts, Cheng) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByQuinupristin+dalfopristinANTIBACTERIAL DRUGSStreptograminsQuinupristin‐Dalfopristin and Linezolid: Evidence and OpinionMiscellaneous antibacterial drugsPharmacoepidemiology and drug safetyQuinupristin/dalfopristin 19 September 2000Volume 133, Issue 6Page: 485KeywordsBloodBronchoscopyChemotherapyCyclophosphamideDrugsHyponatremiaSodiumVancomycinVancomycin resistant enterococcusVentilators ePublished: 19 September 2000 Issue Published: 19 September 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Short-Term Psychotherapy and Hypnosis
Authors: Fred H. Frankel
Journal: Psychotherapy and Psychosomatics (1981)

Phobic patients have been shown to be, on average, more hypnotizable than others. The essence of the phobic experience is not unlike that of the event of hypnosis, and the phobic experience might be a spontaneously occurring panic-filled trance-like or dissociative experience. This dissociation is viewed as a maladaptive mechanism of defense against anxiety, sadness or rage. In addition to enabling the patient to develop a psycho-dynamic understanding of the symptoms, the therapist uses hypnosis and self-hypnosis to help the patient learn more about his dissociative capacity, to become familiar with the mechanism, and to learn to control it. This offers him a way to master the shift in his functioning.
Decreased Uptake on 3-Phase Bone Scintigraphy in Posttalar Fracture Reflex Sympathetic Dystrophy
Authors: Nir Hod, Tifha Horne
Journal: Clinical Nuclear Medicine (2004)

Adult patients with reflex sympathetic dystrophy (RSD), also known as complex regional pain syndrome, of the foot and ankle characteristically have a 3-phase bone scan pattern consisting of diffusely increased tracer uptake with juxtaarticular accentuation of tracer uptake on late-phase images. The authors present an uncommon case of RSD in an adult in whom decreased activity was demonstrated on early and late phase images of bone scintigraphy in the affected limb.
A Case of Acute Septicaemia Treated with Antistreptococcic Serum: Death
Authors: A. V. Crossing, H. W. Webber
Journal: BMJ (1897)

depraved state of the appetite, and is a frequent symptom of eases of anaemia.According to Cobbold, it is a common symptom of worms of all kinds.I have at hand an extract from Dr. Livingstone's last Journals, Vol.ii, p. 83, which I think worth quoting:
My Daughter’s Will
Authors: Paul Rockey
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOME REMARKS ON INSANITY OF THE AGED.Read in the Section of Neurology and Medical Jurisprudence, at the Forty-fourth Annual Meeting of the American Medical Association.
Authors: FRANK PARSONS NORBURY
Journal: JAMA (1893)

The tenure of normal mentality in old age, depends on the sum total of vitality originally deposited and the maintenance of normal equipoise in the brain machinery during the years of active engagements in the affairs of life. The blending of the normal and abnormal mental states renders the psychological study of old age difficult, because what is the normal tenure of one approaches the abnormal change in another; the result is, as Clouston has remarked," the psychology of old age has yet to be written."To the confusion arising from the differentiation of ordinary functional derangements from organic brain diseases, is due the difficulty of diagnosis and clinical classification, which must be experienced to be appreciated. In a clinical study of 196 cases of insanity, occurring in men over sixty years of age, coming under my care, I have been struck by the heterogenous aymptoms, yet similarity of mental affections,
The Agony and the Ecstasy Of the Nephrologist
Authors: David S. David
Journal: JAMA (1972)

To the Editor.—  There are no hopeless diseases, only hopeless remedies. This was, is, and will probably always be true in medicine. But what if the remedy is adequate but not readily available? This is the dilemma that the physician taking care of patients with renal disease faces daily.  First, the existing dialysis facilities in the United States fall far short of the number of patients requiring dialysis. This has forced many, but not all, dailysis centers to set age guidelines above which they will not seriously consider patients for dialysis. Although home dialysis and out-ofhospital care facilities have allowed some older patients to receive dialysis, only a small fraction of the people above the age of 65 years who require dialysis receive it. The rest are allowed to die. The only justification the physician can give himself for this loss of life is that there are far too many
Abstract S5-5: Trastuzumab plus adjuvant chemotherapy for HER2-positive breast cancer: Final planned joint analysis of overall survival (OS) from NSABP B-31 and NCCTG N9831
Authors: E Romond, VJ Suman, J-H Jeong, GW Sledge, CE Geyer, S Martino, P Rastogi, J Gralow, SM Swain, E Winer, G Colon-Otero, C Hudis, S Paik, N Davidson, EP Mamounas, JA Zujewski, N Wolmark, EA Perez
Journal: Cancer Research (2012)

Abstract Background: Preplanned combined analysis of the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-31 trial and North Central Cancer Treatment Group (NCCTG) (Alliance) N9831 Trial compared adjuvant chemotherapy with or without trastuzumab in women with HER2-positive breast cancer. The initial results were reported in 2005 and updated in early 2011 Methods: 4045 patients with HER2-positive operable breast cancer were enrolled to receive doxorubicin plus cyclophosphamide followed by paclitaxel with or without trastuzumab in both trials. The definitive analysis for OS will occur when 710 events have been reported. Results: Median time on study is 8 years. The required number of events have occurred for the definitive analysis for OS to be conducted by the end of September 2012. Updated analyses of disease free survival and related subgroups will also be presented. Supported by NCI grants U10-CA-12027, -69651, -37377, -69974, -44066, U24-CA-114732, CA25224; Breast Cancer Research Foundation; Genentech 35–03 Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr S5-5.
Early cutaneous lesions secondary to hydroxyurea therapy
Authors: Franca Radaelli, Rossella Calori, Paola Faccini, Anna Teresa Maiolo
Journal: American Journal of Hematology (1998)

Hydroxyurea is a usually well-tolerated cytostatic agent, but its side effects include cutaneous lesions that appear after several years of maintenance therapy with hydroxyurea. The reported incidence of such adverse reactions varies from 10 to 35%; in our Center it is 2%. We describe a patient with essential thrombocythemia who presented with ulcers of the hands only 15 days after hydroxyurea treatment. Am. J. Hematol. 58:82–83, 1998. © 1998 Wiley-Liss, Inc.
Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies
Authors: H. Makishima, A. M. Jankowska, Ramon Velasquez Tiu, H. Szpurka, Y. Sugimoto, Z. Hu, Yogen Saunthararajah, K. Guinta, M. A. Keddache, P. Putnam, Mikkael Sekeres, A. R. Moliterno, A. F. List, M. A. McDevitt, Jaroslaw P Maciejewski
Journal: Leukemia (2010)
Response to Letter Regarding Article, “BIPHASIC Trial: A Randomized Comparison of Fixed Lower Versus Escalating Higher Energy Levels for Defibrillation in Out-of-Hospital Cardiac Arrest”
Authors: Ian G. Stiell, Robert G. Walker, Fred W. Chapman, Paula Lank, Lisa P. Nesbitt, Donna Cousineau, James Christenson, Paul Bradford, Sunil Sookram, Ross Berringer, George A. Wells
Journal: Circulation (2007)
Is the delayed introduction of highly allergenic foods effective in primary prevention of food allergy?
Authors: B.J. Vlieg-Boerstra, S.A.A. Wolt-Plompen, C.M.A. Bijleveld, S. van der Heide, B.J. Beusekamp, J. Kukler, E.J. Duiverman, A.E.J. Dubois
Journal: Journal of Allergy and Clinical Immunology (2005)
The P value of empathy
Authors: Craig Watson
Journal: BMJ (2005)

J ust after the beginning of the millennium I contemplate another new contract, a continuing recruitment crisis, and an uncertain future. Some commentators would have me believe that the role of the community physician is not as timeless as I had thought. I am challenged to redefine my role—as a specialist generalist and an expert in multiple pathology—or face extinction at the hands of an army of nurse practitioners who are more adept (and less expensive) at following evidence based protocols. However, my patients have other ideas. Their demand for the attention of their community physician threatens to overwhelm my duty doctor system, my appointment system, my coping strategies, and my morale.

I may defend my professional status by claiming ownership of an advanced body of knowledge or science. But then I reflect that much of the knowledge acquired by doctors is deemed redundant a few years after they qualify and that much of the past and current medical literature is considered to be …
Dysphagia for Several Years
Authors: David A. Kumpe
Journal: JAMA (1971)

Dr. Kumpe: This 56-year-old woman had intermittent difficulty in swallowing for several years. She had occasional soft stools and some very intermittent diarrhea. These are two representative roentgenograms from x-ray series of the upper gastrointestinal tract, one obtained in 1966 and the other in 1970. <h3>Discussion</h3> Dr. Michael A. Glueck: There is dilatation and delayed emptying of the esophagus, as well as persistent dilatation of the second portion of the duodenum (Fig 1). The small bowel appears somewhat dilated, and the folds are normal or slightly prominent. The small bowel is not "wet"; that is, I don't see any evidence of segmentation of the barium sulfate column as it progresses through the small bowel. How long did it take for the barium to pass through the small bowel? Dr. Kumpe: It took several hours. The patient also had a barium enema examination of the colon, and roentgenograms of the chest
Critical Issues in the Development of Health Information Systems in Supporting Environmental Health: A Case Study of Ciguatera
Authors: Sarah Goater, Bonnie Derne, Philip Weinstein
Journal: Environmental Health Perspectives (2010)

Emerging environmental pressures resulting from climate change and globalization challenge the capacity of health information systems (HIS) in the Pacific to inform future policy and public health interventions. Ciguatera, a globally common marine food-borne illness, is used here to illustrate specific HIS challenges in the Pacific and how these might be overcome proactively to meet the changing surveillance needs resulting from environmental change.We review and highlight inefficiencies in the reactive nature of existing HIS in the Pacific to collect, collate, and communicate ciguatera fish poisoning data currently used to inform public health intervention. Further, we review the capacity of existing HIS to respond to new data needs associated with shifts in ciguatera disease burden likely to result from coral reef habitat disruption.Improved knowledge on the ecological drivers of ciguatera prevalence at local and regional levels is needed, combined with enhanced surveillance techniques and data management systems, to capture environmental drivers as well as health outcomes data.The capacity of public HIS to detect and prevent future outbreaks is largely dependent on the future development of governance strategies that promote proactive surveillance and health action. Accordingly, we present an innovative framework from which to stimulate scientific debate on how this might be achieved by using existing larger scale data sets and multidisciplinary collaborations.
Effects of acetate dialysate on transforming growth factor β1, interleukin, and β2-microglobulin plasma levels
Authors: John Anderson, Gary Briefel, Joe M. Jones, J.H. Ryu, Marielena McGuire, Yeo Pyo Yun
Journal: Kidney International (1991)

To evaluate potential adverse effects of acetate use in hemodialysis (HD), we measured plasma interleukin (IL-1 alpha, IL-1 beta, IL-6), TNF alpha, TGF beta 1, and beta 2-microglobulin levels with ELISA assays in normal (N = 9), CRF (N = 6), CAPD (N = 7) and HD (N = 8) subjects and compared the effects of acetate (Ac) and acetate-free (Ac-free) dialysate. TGF beta 1 was the only cytokine consistently detected. Compared to normals (median 57, range 53 to 68 pg/ml, one undetected; N = 8), TGF beta 1 was higher in the CRF (75, 70 to 97 pg/ml, one undetected) and CAPD (75.5, 66 to 116 pg/ml, N = 6) groups (P less than 0.05), and was somewhat higher in the HD (68, 52 to 88 pg/ml) group (P less than 0.10). Acutely, TGF beta 1 pre-HD (70, 63 to 88 pg/ml) increased above normals post AcHD [79.5, 65 to 140 pg/ml uncorrected for ultrafiltration (UF)] and was higher after AcHD versus Ac-free HD both uncorrected (79.5, 65 to 140 pg/ml vs. 70, 52 to 86 pg/ml) and corrected for UF (68, 51 to 115 pg/ml vs. 57, 43 to 69 pg/ml; P less than 0.05). beta 2-microglobulin was not different after AcHD (81.2 +/- 8.0 mg/ml) versus Ac-free HD (72.5 +/- 6.9 mg/ml). Significantly lower serum inorganic phosphorus was also found four hours post-AcHD compared to four hours post-Ac-free HD (0.87 mmol +/- 0.10 SEM vs. 1.05 mmol +/- 0.07 SEM; P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
An acutely swollen knee
Authors: R. Maggio, E. Garcia-Gonzalez, E. Selvi, M. Bardelli, E. Frati, M. Galeazzi
Journal: BMJ (2010)

Hypoxia-inducible factor-1 (HIF-1) is a key gene regulator for cellular adaptation to low oxygen. In addition to hypoxia, several nonhypoxic stimuli, including hormones and growth factors, are an essential part for cell-specific HIF-1 regulation. Our studies have highlighted angiotensin II (AngII), a vasoactive hormone, as a potent HIF-1 activator in vascular smooth muscle cells (VSMC). AngII increases HIF-1 transcriptional activity by modulating specific signaling pathways. In VSMC, p42/p44 mitogen-activated protein kinase (MAPK) pathway activation is essential for HIF-1-mediated transcription during AngII treatment. The present study shows that PD184161, a potent MEK1/2 inhibitor, is a HIF-1 blocker in Ang II-treated VSMC. Unlike PD98059, a widely-used MEK1/2 inhibitor, we found that PD184161 blocked AngII-driven HIF-1α protein induction in a dose-dependent manner. Interestingly, the effect of PD184161 was specific to nonhypoxic activators, since HIF-1α induction by hypoxia (1% O2) was unaffected under similar conditions. VSMC treatment with MG132, a proteasome inhibitor, indicated that PD184161 influenced HIF-1α protein stability. PD184161 also increased HIF-1α binding to VHL, a E3 ligase component and an indication of HIF-1α hydroxylation. Finally, we show that PD184161 blocked mitochondrial ROS (mtROS) production and cellular ATP levels, while enhancing ascorbate availability in AngII-treated VSMC. Taken together, our study indicates that, independently of p42/p44MAPK activation, PD184161 blocks mtROS generation by AngII, leading to reestablishment of cellular ascorbate levels, increased VHL binding and decreased HIF-1α stability. Therefore, this study reveals a previously unsuspected role for PD184161 as a HIF-1 inhibitor in VSMC under nonhypoxic conditions.
Microvascular Anastomoses for Cerebral Ischemia.
Authors: Jose L. Salazar
Journal: Annals of Internal Medicine (1979)

Surgical treatment of vascular disease of the limbs, heart, and other body parts is well known, but until recently, few investigators dealt with operations to relieve ischemia due to cerebrovascular disease. Surgical techniques for cerebral revascularization are presented in this book.  The basic anatomic, physiologic, and hemodynamic changes in stroke are discussed, followed by clinical and laboratory evaluation of direct and collateral circulation in the ischemic brain and basic laboratory studies in animals. There is information on the indications for operation, patient selection, management of risk factors, and a variety of operations. Most emphasis is placed on the most popular procedure, anastomosis of the superficial temporal artery to a branch of the middle cerebral artery. The follow-up of such operations is still brief (the first human case dates only from 1967), but there seems to be benefit for properly selected patients. Particular attention is paid to evaluation of changes in
Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure
Authors: Alberto Ortiz, Adrian Covic, Danilo Fliser, Denis Fouque, David Goldsmith, Mehmet Kanbay, Francesca Mallamaci, Ziad A Massy, Patrick Rossignol, Raymond Vanholder, Andrzej Wiecek, Carmine Zoccali, Gérard M London
Journal: The Lancet (2014)
Delivery of Primary Health Care — Union Style
Authors: R.W. Chamberlin, J.F. Radebaugh
Journal: New England Journal of Medicine (1976)

The primary health-care program developed by the United Farm Workers of America, an example of a consumer-controlled system, provides quality health care at locations and time convenient to patients and employs bilingual clinic personnel from the same worker background to bridge the cultural gap between provider and consumer. By combining health-care delivery with union activities, it has been possible to finance the system through grower contribution by contract and to alter unhealthy working and living conditions on the farms. However, the lack of decision-making power by the health workers has resulted in poor working conditions and a high turnover of personnel. Complete consumer control has built into it the same hazards as complete professional control, and some balance of power is clearly necessary if the needs of both are to be adequately met.
Fabric softeners and proteinuria.
Authors: T M Hayes, A Lashford
Journal: BMJ (1970)

DBIATISOUNALincompetence never exhibit the distressing symptoms or show the gross lesions that are found in patients with incompetence of perforators just above the ankle.You state that it takes less than an hour to examine both legs by thermography and that this method can be extremely accurate, but you have omitted to state how effective is this method in detecting all incompetent perforators.Mr. K. D. Patil and colleagues (p.195) correctly detected 79 incompetent perforators in between 62 and 66 limbs, and Beesley and Fegant correctly detected 40 incompetent perforators in 32 limbs using thermography.This is less than two perfo- rators per limb.Neither we nor Mr. Patil investigated how many incompetent perforators were not detected by this method, but I am sure we would all agree that some remained undetected.The clinical method of detecting incompetent perforators used by Mr. Patil and others revealed 50 sites of incompetence in 62-66 limbs (say 0.9 per limb), and he states he was surprised at operation to palpate fascial defects which had previously been missed.This suggests that the exam- ination of the elevated limb was not per- formed pre-operatively.In our series, using the method described by Fegan2 of palpating the elevated limb and then observing points of digital control of retrograde filling, we detected 46 incompetent perforators in 32 limbs.The total number of incompetent per- forators diagnosed pre-operatively by Mr. absorber system are tenuous, to say the least.-Weare, etc.,
Activated STAT5 Promotes Long-Lived Cytotoxic CD8+ T Cells That Induce Regression of Autochthonous Melanoma
Authors: Magali Grange, Michel Buferne, Grégory Verdeil, Lee Leserman, Anne-Marie Schmitt-Verhulst, Nathalie Auphan-Anezin
Journal: Cancer Research (2011)

Immunotherapy based on adoptive transfer of tumor antigen-specific CD8(+) T cell (TC) is generally limited by poor in vivo expansion and tumor infiltration. In this study, we report that activated STAT5 transcription factors (STAT5CA) confer high efficiency on CD8(+) effector T cells (eTC) for host colonization after adoptive transfer. Engineered expression of STAT5CA in antigen-experienced TCs with poor replicative potential was also sufficient to convert them into long-lived antigen-responsive eTCs. In transplanted mastocytoma- or melanoma-bearing hosts, STAT5CA greatly enhanced the ability of eTCs to accumulate in tumors, become activated by tumor antigens, and to express the cytolytic factor granzyme B. Taken together, these properties contributed to an increase in tumor regression by STAT5CA-transduced, as compared with untransduced, TCs including when the latter control cells were combined with infusion of interleukin (IL)-2/anti-IL-2 complexes. In tumors arising in the autochthonous TiRP transgenic model of melanoma associated with systemic chronic inflammation, endogenous CD8(+) TCs were nonfunctional. In this setting, adoptive transfer of STAT5CA-transduced TCs produced superior antitumor effects compared with nontransduced TCs. Our findings imply that STAT5CA expression can render TCs resistant to the immunosuppressive environment of melanoma tumors, enhancing their ability to home to tumors and to maintain high granzyme B expression, as well as their capacity to stimulate granzyme B expression in endogenous TCs.