tbuckley/cabot-search huggingface dataset:
High-Dose Cytarabine in Induction Treatment Improves the Outcome of Adult Patients Younger Than Age 46 Years With Acute Myeloid Leukemia: Results of the EORTC-GIMEMA AML-12 Trial
Authors: Roelof Willemze, Stefan Suciu, Giovanna Meloni, Boris Labar, Jean-Pierre Marie, Constantijn J.M. Halkes, Petra Muus, Martin Mistrik, Sergio Amadori, Giorgina Specchia, Francesco Fabbiano, Francesco Nobile, Marco Sborgia, Andrea Camera, Dominik L.D. Selleslag, Francois Lefrère, Domenico Magro, Simona Sica, Nicola Cantore, Meral Beksac, Zwi Berneman, Xavier Thomas, Lorella Melillo, Jose E. Guimaraes, Pietro Leoni, Mario Luppi, Maria E. Mitra, Dominique Bron, Georges Fillet, Erik W.A. Marijt, Adriano Venditti, Anne Hagemeijer, Marco Mancini, Joop Jansen, Daniela Cilloni, Liv Meert, Paola Fazi, Marco Vignetti, Silvia M. Trisolini, Franco Mandelli, Theo de Witte
Journal: Journal of Clinical Oncology (2013)

Cytarabine plays a pivotal role in the treatment of patients with acute myeloid leukemia (AML). Most centers use 7 to 10 days of cytarabine at a daily dose of 100 to 200 mg/m(2) for remission induction. Consensus has not been reached on the benefit of higher dosages of cytarabine.The European Organisation for Research and Treatment of Cancer (EORTC) and Gruppo Italiano Malattie Ematologiche dell' Adulto (GIMEMA) Leukemia Groups conducted a randomized trial (AML-12; Combination Chemotherapy, Stem Cell Transplant and Interleukin-2 in Treating Patients With Acute Myeloid Leukemia) in 1,942 newly diagnosed patients with AML, age 15 to 60 years, comparing remission induction treatment containing daunorubicin, etoposide, and either standard-dose (SD) cytarabine (100 mg/m(2) per day by continuous infusion for 10 days) or high-dose (HD) cytarabine (3,000 mg/m(2) every 12 hours by 3-hour infusion on days 1, 3, 5, and 7). Patients in complete remission (CR) received a single consolidation cycle containing daunorubicin and intermediate-dose cytarabine (500 mg/m(2) every 12 hours for 6 days). Subsequently, a stem-cell transplantation was planned. The primary end point was survival.At a median follow-up of 6 years, overall survival was 38.7% for patients randomly assigned to SD cytarabine and 42.5% for those randomly assigned to HD cytarabine (log-rank test P = .06; multivariable analysis P = .009). For patients younger than age 46 years, survival was 43.3% and 51.9%, respectively (P = .009; multivariable analysis P = .003), and for patients age 46 to 60 years, survival was 33.9% and 32.9%, respectively (P = .91). CR rates were 72.0% and 78.7%, respectively (P < .001) and were 75.6% and 82.4% for patients younger than age 46 years (P = .01) and 68.3% and 74.8% for patients age 46 years and older (P = .03). Patients of all ages with very-bad-risk cytogenetic abnormalities and/or FLT3-ITD (internal tandem duplication) mutation, or with secondary AML benefitted from HD cytarabine.HD cytarabine produces higher remission and survival rates than SD cytarabine, especially in patients younger than age 46 years.
Hospitals in India woo foreign patients
Authors: Ganapati Mudur
Journal: BMJ (2004)

Having endured intractable pain caused by osteoarthritis of the hip for two years, a 44 year old woman from Norwich had two options—wait for her turn in the NHS or seek treatment in a private hospital.

She took a 10 hour flight to India and checked into Apollo Hospital in the southern Indian city of Chennai. There, last Saturday, an orthopaedic surgeon performed a Birmingham hip resurfacing procedure on her. She expects to be home in three weeks—but not before a visit to a traditional Indian herbal medicine centre, arranged by the hospital.

The British woman is among a growing number of foreigners turning to private tertiary care hospitals in India for medical treatment, which is leading to health tourism. Large hospitals in Mumbai, Chennai, and New Delhi have long been receiving patients from neighbouring South Asian and Gulf countries. Now they are trying to attract patients from Africa, Europe, and North America, marketing themselves as centres capable of delivering world class medical services at low cost.

“Patients from the UK and North America make up a little more than a trickle right now, but there is big potential for growth,” said Mr Anil Maini, head of healthcare business marketing at the Escorts …
US defeated on antiabortion statements at UN women's meeting
Authors: Janice Hopkins Tanne
Journal: BMJ (2005)

The United States was defeated in two attempts to insert antiabortion statements into resolutions at the UN conference on the status of women. The review of progress in the decade since the 1995 Beijing conference ended as it began.

In an opening speech, UN secretary general Kofi Annan noted progress in women's improved life expectancy, ability to earn, and lower fertility rates and girls' access to primary education. He said that the situation was worse in other areas. Trafficking in women …
Pressure-flow studies in man during atrial fibrillation
Authors: Joseph C. Greenfield, Alexander Harley, Howard K. Thompson, Andrew G. Wallace
Journal: Journal of Clinical Investigation (1968)

In 13 patients who had atrial fibrillation the ascending aortic pressure-flow relationships were measured by the pressure gradient technique. Both the pressure and flow curves were similar in contour to ones previously obtained by this method. From these recordings, relationships between the phases of systole, the ventricular filling time, and various derived parameters of pressure and flow such as the pulse pressure, stroke volume, peak flow, stroke work, and peak power were evaluated. For stroke volumes greater than 15 cm(3) there was little change in the duration of systole in an individual patient. In each patient both the preejection period and the duration of ejection showed a good correlation with stroke volume, peak flow, stroke work, and peak power. When data from all patients were examined, the relationship between stroke volume and duration of ejection was found to be curvilinear and had an overall correlation of r=0.91. There was marked variation from patient to patient in duration of both the preejection period and systole. Similar correlations between the phases of systole were noted with peak flow, peak power, and stroke work. A positive but mediocre correlation was found between the previous RR interval (an index of ventricular filling time) and the subsequent stroke volume. The correlation, in six patients, between two previous RR intervals and stroke volume was considerably better. The relationship between the pulse pressure and stroke volume was reasonably close except in one patient; however, the group correlation was poor due to differences between individuals.
Outpatient Management of Advanced Cancer: Symptom Control, Support, and Hospicein-the-Home
Authors: Kathleen A. Havlin
Journal: JAMA (1986)

<i>Outpatient Management of Advanced Cancer</i>is designed as a guide to clinicians involved in the palliative care of patients with advanced cancer. The book is organized into three major sections: (1) symptom control; (2) psychosocial support; and (3) hospice-in-the-home. If one were to formulate an underlying theme to this text, it would be as described by the author—"an active, positive approach to the care of terminally ill patients.... Many difficulties can be tolerated, and both physical and emotional distress can be managed, the truth may be bad, but it need not be overwhelming." The collaboration of the author with other physicians, nurses, mental health workers, and social workers is readily apparent and laudable. This book is well organized and well referenced. Appropriate works from contemporary and classic literature enhance the reading of a book about what can be a dreary topic. Of particular interest is the section about symptom control,
Pericarditis and Atrial Arrhythmias
Authors: Jonas Brachfeld
Journal: JAMA (1963)

<h3>To the Editor:—</h3> The editorial on pericarditis and atrial arrhythmias (<i>JAMA</i><b>185</b>:316 [July 27] 1963) prompts me to describe a case of pericarditis in which an unusual coincidence may have accounted for atrial arrhythmias. In the fall of 1961, we had an opportunity to observe seven cases of pericarditis at Rancocas Valley Hospital during a local epidemic of Coxsackie B virus infections. Of these, only one patient showed atrial arrhythmias. This 38-year-old woman showed atypical clinical, radiological, and electrocardiographic evidence of severe pericarditis, with high fever and a stormy course. During the episode, the patient was noted to have many atrial arrhythmias, including runs of atrial tachycardia, atrial flutter, and atrial fibrillation. The episode subsided in 2 weeks, when all cardiac manifestations regressed and the electrocardiogram became entirely normal. When admitted to the hospital, the patient also expressed concern about a fine tremor she had noted in the preceding
15-deoxy-Δ12,14-PGJ2: endogenous PPARγ ligand or minor eicosanoid degradation product?
Authors: William S. Powell
Journal: Journal of Clinical Investigation (2003)

15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) affects gene transcription by activating PPARγ and by covalent addition to transcription factors and signaling molecules, However, it is not known whether the high concentrations of 15d-PGJ2 required for these responses are consistent with physiological levels. A new study suggests that in vivo 15d-PGJ2 levels are actually several orders of magnitude below the levels required to induce many of the biological effects attributed to this molecule.
Detection Rate and Operating Time Required for γ Probe-Guided Sentinel Lymph Node Resection after Injection of Technetium-99m Nanocolloid into the Prostate with and without Preoperative Imaging
Authors: Sebastian H. Warncke, Agostino Mattei, Frank G. Fuechsel, Sebastian Z'Brun, Thomas Krause, Urs E. Studer
Journal: European Urology (2007)
Efficacy of Low-Frequency Positive-Pressure Ventilation-Extracorporeal CO<sub>2</sub> Removal: From the Authors
Authors: Alan H. Morris
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

"Efficacy of Low-Frequency Positive-Pressure Ventilation-Extracorporeal CO2 Removal: From the Authors." American Journal of Respiratory and Critical Care Medicine, 151(4), pp. 1269–1270
A Test for Spinal-Fluid Alcohol in Torula Meningitis
Authors: David M. Dawson, Ahmed Taghavy
Journal: New England Journal of Medicine (1963)

CASES of chronic meningitis in which an organism cannot be recovered from the spinal fluid are occasionally encountered and pose a difficult clinical problem. When the disease is accompanied by a persistently low spinal-fluid sugar, the differential diagnosis commonly becomes narrowed to carcinomatous meningitis, sarcoidosis of the meninges and cryptococcosis or other fungal meningitis. Any laboratory aids are of benefit in this situation, and for this reason we are reporting a test that, when positive, should strongly suggest the diagnosis of fungal meningitis.Yeasts uniformly contain the enzyme alcohol dehydrogenase whereas bacteria do not, and therefore the end product of . . .
787 Worsening of cerebral hyperemia in acute liver failure with severe hepatic encephalopathy following terlipressin?
Authors: D SHAWCROSS, N DAVIES, R MOOKERJEE, P HAYES, A LEE, R WILLIAMS, R JALAN
Journal: Hepatology (2003)

The output intensity from a N2 laser pumped dye laser has been optimized at 507 nm by the use of a mixture of solvents with a single dye. The wavelength of maximum output power of coumarin 481 was found to depend on the composition of the solvent mixture. With coumarin 481 in a 2: 1 volume mixture of p-dioxane and ethanol, a maximum power output was obtained at 507 nm, versus 481 nm for the same dye in pure p-dioxane or 517 nm for the same dye in pure ethanol, A 3 : 1 volume mixture of p-dioxane and ethanol and a 1 : 1 mixture gave lasing maxima at 501 nm and 511 nm, respectively. The energy per pulse at 507 nm obtained with coumarin 481 in the 2 : 1 mixture was compared with the energy per pulse obtained with coumarin 481 in pure p-dioxane and with the energy per pulse obtained with coumarin 540A in both high resolution. The relative photochemical stabilities of cuomarin 481 in the 2 : 1 mixture, coumarin 481 in pure p-dioxane and coumarin 540A in pure p-dioxane are also evaluated.
Neonatal alloimmune thrombocytopenic purpura associated with sensitization against the platelet‐specific antigen Yuk<sup>a</sup>
Authors: Tadashi Matsuda, Hisashi Yonaha, Eiichi Azuma, Minoru Sakurai, Shigemi Imai
Journal: American Journal of Hematology (1990)

Abstract We report a Japanese newborn who developed alloimmune thrombocytopenia by the antibodies to the newly discovered platelet antigen Yuk a . The infant recovered uneventfully in 10 days without specific treatment. Antiplatelet ailoantibodies in the patient were IgG class detected by mixed passive hemagglutination (MPHA). Family study showed that Yuk a antigen was inherited as an autosomal dominant trait. Cases with Yuk a ‐associated alloimmune thrombocytopenia are reviewed.
THE ACTIVITY OF METABOLIC ENZYMES OF HUMAN EPIDERMIS IN RELATION TO AGE
Authors: S. YAMASAWA, D. CERIMELE, F. SERRI
Journal: British Journal of Dermatology (1972)

Summary.— The activity of 14 enzymes, representative of the main metabolic pathways, was studied in the epidermis of 63 normal human subjects ranging in age from 1 month to 90 years. The activity was assayed with microfluorometric methods which allow the use of samples of epidermis very much reduced in size (0·3 μg to 1 μg). No difference of activity was observed in any of the enzymes studied despite the varied ages. The lack of influence of age on the activity of the enzymes in human epidermis enhances the significance of the variations which are reported in some pathological conditions (like psoriasis, chronic sun-damaged skin and neoplasms).
Diseases of Porphyrin Metabolism.
Authors: C. J. Watson
Journal: JAMA (1963)

This is generally an excellent, compact, and well-organized treatise of the more significant up-to-date information concerning normal porphyrin metabolism and biosynthesis and the disturbances in various disease states, notably porphyria. The book is well written and the format and general order usually make for clarity. The index is quite satisfactory. It would be surprising if there were not at least occasional errors or serious omission in a work whose main objective is to treat such a large and complex topic in a relatively abbreviated manner. One example is the inexplicable statement that Sachs described the characteristic insolubility in chloroform of the red porphobilinogen Ehrlich aldehyde compound. Sachs did mention the relative insolubility of porphobilinogen itself in polar solvents, but the failure of the red aldehyde compound to be extracted from the aqueous phase by chloroform was first pointed out by Schwartz and Watson and became the basis of the test
Prehospital Thrombolysis for Stroke
Authors: Steven Warach
Journal: JAMA Neurology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Normal Scapulae or Rib Lesions Value of Arm-abducted and Arm-adducted Views
Authors: CHARLES A. STEWART, OSCAR A. FERNANDEZ
Journal: Clinical Nuclear Medicine (1991)

On bone scintigrams the inferior angle normally appears hotter than the remainder of the scapula. On posterior views this activity may mimic or obscure underlying rib lesions. When asymmetry is encountered, additional views are commonly obtained to separate the scapula from the ribs. Presented is a case of symmetric, bilateral rib fractures, which were obscured by the inferior angles of the scapulae on an arm-abducted posterior view but clearly demonstrated on an arm-adducted posterior view. With their symmetrical distribution, these lesions could have been missed if only a single posterior view had been obtained.
Radioisotope Myelography in the Detection of Pleural-Dural Communication as a Source of Recurrent Meningitis
Authors: PAUL ROSEN, TUHIN K. CHAUDHURI
Journal: Clinical Nuclear Medicine (1983)

A pleural-dural communication resulting in recurrent meningitis was diagnosed using radioisotope myelography with Tc-99m DTPA. The utility and advantages of this technique are discussed.
Severe flucloxacillin-induced acute generalized exanthematous pustulosis (AGEP), with toxic epidermal necrolysis (TEN)-like features: does overlap between AGEP and TEN exist? Clinical report and review of the literature
Authors: S. van Hattem, G.I. Beerthuizen, S.H. Kardaun
Journal: British Journal of Dermatology (2014)

Acute generalized exanthematous pustulosis (AGEP) and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) are rare but severe cutaneous adverse drug reactions. Especially in TEN, large areas of the skin and mucosae may become detached. Although AGEP and SJS/TEN are distinct entities with a different clinical picture, pathogenesis, prognosis and treatment, they may share some features, raising the hypothesis of overlap between both entities. We present a severe case of AGEP, caused by flucloxacillin, clinically presenting with TEN-like features and pronounced systemic symptoms with haemodynamic and respiratory instability. Furthermore, we present a review of the literature on cases of AGEP with features resembling SJS/TEN or a supposed overlap with SJS/TEN.
McArdle's Disease
Authors: DAVID M. DAWSON
Journal: Annals of Internal Medicine (1968)

In a family with McArdle's syndrome, four siblings all had frequent muscle cramps caused by exercise and had episodes of myoglobinuria. The absence of phosphorylase activity was shown in biopsy specimens from three of the four. When biopsy material was used from one patient, there was no recognizable protein with the chromatographic properties of phosphorylase, thus confirming earlier reports that antibodies directed against human phosphorylase do not cross-react with muscle extracts from patients with McArdle's disease. An extensive family history was gathered, and the inheritance seems to be that of an autosomal recessive gene. A susceptibility to brief painful cramps during exercise may be a useful test for detection of asymptomatic heterozygotes.
TCT-167 Coarctation Stenting Through the Carotid Approach in Neonates and Infants
Authors: Carlos Pedra, Luis O. Campaña, Marcelo Ribeiro, Rodrigo Costa, Paulo Chaccur, Fabiana Succi, Glaucio Furlanetto, Virginia Santana, Simone Pedra, Valmir Fontes
Journal: Journal of the American College of Cardiology (2014)
UV-irradiation-induced DNA immobilization and functional utilization of DNA on nonwoven cellulose fabric
Authors: Masanori Yamada, Kozue Kato, Kazuna Shindo, Motoyoshi Nomizu, Masahiro Haruki, Nobuo Sakairi, Kousaku Ohkawa, Hiroyuki Yamamoto, Norio Nishi
Journal: Biomaterials (2001)
Abstract 4656: DNA repair polymorphisms as predictors of Graft-versus-Host Disease after allogeneic hematopoietic cell transplants
Authors: Bharat Thyagarajan, Bruce Lindgren, Saonli Basu, Sriharsha Nagaraj, Myron Gross, Daniel Wesidorf, Mukta Arora
Journal: Cancer Research (2010)

Abstract Graft versus host disease (GVHD) remains a major source of morbidity and mortality among patients undergoing hematopoietic cell transplants (HCT). Tissue damage as a result of treatment is the initiating event in the pathogenesis of GVHD and variations in DNA repair can influence the amount of tissue damage in response to treatment modalities used in HCT. Since DNA damage caused by therapeutic agents such as alkylating agents and ionizing radiation used frequently in pre- HCT conditioning regimens is commonly repaired by the base excision repair (BER) pathway we hypothesized that genetic polymorphisms in the BER pathway will be associated with GVHD after HCT. We evaluated the association between single nucleotide polymorphisms (SNPs) (n= 179) in the BER pathway with acute GVHD and chronic GVHD in a cohort of 470 recipients who underwent allogeneic HCT for treatment of hematologic malignancies at the University of Minnesota. After adjustment for donor type, diagnosis, disease status at transplant and gender mismatch, two SNPs in RFC1 (Replication Factor C) gene (rs1057807 and rs4975003) were associated with a decreased risk of grade II-IV acute GVHD (HR:0.74-0.77; p≤0.01) and one SNP, rs6844176, in RFC1 gene was associated with increased risk of grade II-IV acute GVHD (HR:1.39, p=0.001). The rs3730914 SNP in the LIG1 (Ligase I) gene was also associated with a decreased risk of grade III-IV acute GVHD (HR: 0.38; p=0.005). One SNP, rs1805410, in the PARP1 (poly ADP-ribose polymerase 1) gene was associated with increased risk of chronic GVHD (HR: 1.44; p=0.01) post HCT. These findings suggest that SNPs in the BER pathway can be used as genetic biomarkers to predict individuals at high risk for GVHD. If these findings are confirmed, modulation of pre-transplant conditioning may alter risk in these patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4656.
Therapy for Multinodular Goiter
Authors: Claude E. Welch
Journal: JAMA (1966)

The multinodular goiter is associated with the complications of malignant disease and hyperthyroidism. The important indications for surgery include large glands that may or may not be toxic and those with a hard or tender dominant nodule or with the signs suspicious of cancer including hardness, fixation, pressure symptoms, enlarged satellite lymph nodes, and lack of improvement on thyroid therapy. Thyroid scans are helpful when positive but useless if equivocal. Selection of patients for observation, or substitution therapy, or operation, must rest upon these individual considerations.