tbuckley/cabot-search huggingface dataset:
Gall stones in sickle cell disease in the United Kingdom.
Authors: L R Bond, S R Hatty, M E Horn, M Dick, H B Meire, A J Bellingham
Journal: BMJ (1987)

The prevalence of gall stones was studied prospectively by abdominal ultrasound examination in 131 patients with sickle cell disease aged 10-65 years. Of 95 patients with homozygous sickle cell disease, 55 (58%) had gall stones or had had a cholecystectomy. Gall stones were present in four out of 24 (17%) patients with haemoglobin S + C disease and two out of 12 (17%) with haemoglobin S beta thalassaemia. The presence of gall stones was not related to sex, geographical origin, or haematological variables and was not associated with abnormal results of liver function tests. Symptoms typical of biliary colic were reported by 32 out of 47 adult patients with gall stones, and cholecystitis or cholestasis was diagnosed in 18. Cholecystectomy was performed in 29 patients with good relief of symptoms in most cases. Postoperative complications were common, occurring in 10 of the 28 patients who could be evaluated, but not generally serious; they were considerably lessened by a preoperative exchange transfusion that reduced the haemoglobin S concentration to below 40%. It is suggested that all patients with sickle cell disease should be screened for gall stones and that elective cholecystectomy should be performed in those with symptoms or complications.
334 NON-INVASIVE DIAGNOSIS OF LIVER LESIONS BY BLOOD TESTS IN NAFLD
Authors: P. Calès, J. Boursier, J. Chaigneau, V. Roullier, F. Lainé, J. Sandrini, S. Michalak, I. Hubert, N. Dib, F. Oberti, S. Bertrais, G. Hunault, M.C. Rousselet, C. Cavaro-Ménard, Y. Gallois, Y. Deugnier
Journal: Journal of Hepatology (2010)
Children should have electrocardiography before taking drugs for hyperactivity
Authors: Janice Hopkins Tanne
Journal: BMJ (2008)

Children with attention deficit hyperactivity disorder should have an electrocardiogram taken and a cardiac evaluation before they begin to take drugs for the disorder, the American Heart Association said in a scientific statement published on 21 April.

The stimulant drugs used to treat the disorder can increase heart rate and blood pressure and may be a concern if children have a heart condition, says the statement, published online in Circulation (doi: 10.1161/circulationaha.107.189473).

As many as 2% of apparently healthy school age children have potentially serious undiagnosed heart conditions that can be identified by electrocardiography but that may not be detected on routine physical examination, said Victoria Vetter, head of the …
&lt;emph type="ital"&gt;Head of an Oba&lt;/emph&gt;
Authors: Thomas B. Cole
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Violence in America: Time to Bite the Bullet Back-Reply
Authors: George D. Lundberg
Journal: JAMA (1992)

In Reply.  —I agree with the NRA when it says Guns don't kill people; people kill people. That is why the major thrust of our proposals dealt with gun owners and users and not guns themselves.  Responses to our publications about violence in the 10 journals of the AMA in June 1992 was swift and enormous. Major international public media attention (print and electronic) continues, especially in magazines and columns. Government leaders, member physicians, newspaper editors, students, and the public at large (including many gun owners) were highly supportive. The AMA authorized the compilation of all articles into one 434-page book called Violence , 1 now available for sale from our Chicago office by calling (800) 621-8335.  By no means, however, did everyone we heard from support the recommendations of the Editorial, as evidenced by some of these accompanying letters.  To summarize our current position, the Koop-Lundberg proposal to treat guns
Atrial Fibrillation in Practice
Authors: Bharat K Kantharia
Journal: Journal of the Royal Society of Medicine (2002)

With rapid advances in our understanding of atrial fibrillation, the focus in clinical practice is switching from prevention and palliation to complete cure. For information on the subject, clinicians can turn to numerous websites, and the topic is covered in many textbooks. However, Professor Lip and his publisher have identified the need for a pocket-size book on this most common of arrhythmias. In 68 pages and nine chapters he concisely covers all major aspects of atrial fibrillation from epidemiology to management strategies.

The book is intended especially for internists, general practitioners, junior physicians and medical students, yet Professor Lip's simplification of the pathophysiology and electrophysiological mechanisms and pharmacological management will not rob it of interest to cardiologists or even cardiac electrophysiologists; indeed, it will prove a good reference source on the subject. Although a ‘British’ theme is evident throughout the book, especially in the chapters on epidemiology and management strategies, the coverage of all issues is based on worldwide research.

On the inside of the cover is a simple flow diagram for management of atrial fibrillation that will help clinicians choose a pharmacological treatment and decide when to refer to a specialist centre for non-pharmacological therapy. In the USA, we are seeing increasing use of non-pharmacological methods—especially radiofrequency ablations—as adjunctive and at times curative modalities. The remarkable economy of space is achieved by liberal use of tables, boxes and bullet points; each chapter ends with a useful list of references as ‘further reading’. The quality of illustrations is good, and tables on pharmacological agents (referring to classification, route of administration, dosages and potential adverse effects) offer a quick and reliable source of information. Professor Lip has succeeded brilliantly with this brief guide.
The Importance of the Right Heart
Authors: Lawrence J Hergott
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Staff Organization and Administration
Authors: Robert E. Toomey
Journal: JAMA (1967)

In our society today, the medical staff of a voluntary nonprofit hospital is an organizational anomaly. The individual physicians in most communities are private entrepreneurs. They establish a private practice in any location in the community that they want. They determine for themselves exactly what services they will provide in their own office. Their existence in their own office practice is relatively uncomplicated and unregulated. However, physicians are considered part of a profession that has both moral and social obligations to the community in which they live. Because of this, they must participate in activities affecting the entire community and not just that portion they see in their private office. From the beginning, physicians live in a dichotomous world. The first aspect of the dichotomy is expressed in their private office practice. The second facet is expressed in their use of the hospital. It is in the hospital setting that
Bone Imaging: Radionuclide Scan vs MRI-Reply
Authors: Steven E. Harms
Journal: JAMA (1990)

<h3>In Reply.—</h3> Unfortunately, the bone scan figures used in our article for the metastatic lesion of the sacrum in Fig 1 and the stress fracture of the hip in Fig 6 were transposed. The stress fracture was an anterior view on the bone scan and the sacral metastasis was a posterior view. We agree that the bone scan views as shown in the figures would have been the wrong views for the pathologic findings displayed by MRI. In fact, the correct views were obtained but were printed with the wrong corresponding MRI views. Both bone scintigrams were normal as shown in the figures. We apologize for this mishap. We stand behind our statements regarding the use of radionuclide bone scans compared with MRI. Radionuclide bone scanning is a useful and sensitive study for the global view of the skeleton. There is now well-documented evidence that radionuclide bone scans are
How to make an alveolus
Authors: E. R. Weibel
Journal: European Respiratory Journal (2008)

<h3>Abstract</h3> At the end of 2019, an outbreak of unknown pathogen pneumonia occurred in China, then it was named corona virus disease 2019 (COVID-19). With the rapid spread of COVID-19, a series of strict prevention and control measures were implemented to cut the spread of the epidemic. Influenza as a respiratory tract infection disease as COVID-19 might also be controlled. To assess the effects, we used the total passenger numbers sent in mainland China from 2018 to 2020 and the daily number of railway passenger (DNRP) flow in 2020 during Spring Festival travel rush to reflect the population movement and further to analyze newly and cumulative confirmed COVID-19 and influenza. We found that with implementing the series measures on COVID-19, not only COVID-19, but also influenza mitigated in China. The prevention and control measures for COVID-19 might be used in controlling respiratory tract diseases, and reducing the national health economic burden. When other countries issue measures on COVID-19 and influenza, they should consider adopting more aggressive epidemic prevention and control strategies.
Is it unethical for doctors to encourage healthy adults to donate a kidney to a stranger? No
Authors: A. J. Cronin
Journal: BMJ (2011)

<b>Walter Glannon</b> (doi:10.1136/bmj.d7179) argues that doctors should not encourage their patients to put themselves at risk for the benefit of others, but <b>Antonia Cronin</b> believes that encouraging altruistic donation is legitimate
Loss of Skeletal Calcium by Patients on Maintenance Dialysis
Authors: P. J. Atkinson, R. R. West, F. M. Parsons, G. W. Reed
Journal: BMJ (1970)

Direct radiological measurements of the mineral content of femoral bone were performed in 13 patients on maintenance dialysis. They were found to be sufficiently sensitive to be used for monitoring, and it is suggested that the technique gives more information than do calcium-balance studies.
An Essential Role for a MEK-C/EBP Pathway during Growth Factor-Regulated Cortical Neurogenesis
Authors: Catherine Ménard, Paul Hein, Annie Paquin, Aviva Savelson, Xiu Ming Yang, Doron Lederfein, Fanie Barnabé-Heider, Alain A Mir, Esta Sterneck, Alan C Peterson, Peter F Johnson, Charles Vinson, Freda D Miller
Journal: Neuron (2002)
Improving the Success of Organ Transplantation
Authors: Charles B. Carpenter
Journal: New England Journal of Medicine (2000)

The concept of drug-induced immunosuppression arose in the late 1950s with the observation by Schwartz and Dameshek that 6-mercaptopurine, developed as an antileukemic drug, was effective in blocking primary, but not secondary, antibody responses in rabbits.1 Several synthetic congeners prepared by Hitchings and Elion at the Wellcome Laboratories were then screened by Murray and Calne in dogs with renal transplants. With the discovery in 1962 that one of these congeners, azathioprine, was clinically useful as an immunosuppressive drug, the era of clinical organ transplantation began.2 The initial success rate for patients receiving cadaveric renal transplants, previously zero, was relatively poor, . . .
Tinea nigra secondary to <i>Exophiala werneckii</i> responding to itraconazole
Authors: G. Gupta, A.D. Burden, G.S. Shankland, M.E. Fallowfield, M.D. Richardson
Journal: British Journal of Dermatology (1997)

Journal Article Tinea nigra secondary to Exophiala werneckii responding to itraconazole Get access G. Gupta, G. Gupta Department of Dermatology, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, Scotland, U.K. Search for other works by this author on: Oxford Academic Google Scholar A.D. Burden, A.D. Burden Department of Dermatology, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, Scotland, U.K. Search for other works by this author on: Oxford Academic Google Scholar G.S. Shankland, G.S. Shankland Regional Mycology Reference Laboratory, Department of Dermatology, University of Glasgow, Glasgow G11 6NT, Scotland, U.K. Search for other works by this author on: Oxford Academic Google Scholar M.E. Fallowfield, M.E. Fallowfield Department of Dermatology, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, Scotland, U.K. Search for other works by this author on: Oxford Academic Google Scholar M.D. Richardson M.D. Richardson Regional Mycology Reference Laboratory, Department of Dermatology, University of Glasgow, Glasgow G11 6NT, Scotland, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 137, Issue 3, 1 September 1997, Pages 483–484, https://doi.org/10.1111/j.1365-2133.1997.tb03775.x Published: 01 September 1997
Predictors of Relapse in Major Depressive Disorder
Authors: Martin B. Keller
Journal: JAMA (1983)

Risk of relapse into an affective episode was high in the months immediately after recovery from a major depressive disorder (MDD) in 141 subjects with nonbipolar depression, without a preexisting dysthymic disorder. The probability of relapse then declined steadily during the duration of the follow-up (median follow-up, 62 weeks from recovery). In patients entering the study during their first affective episode, the Research Diagnostic Criteria secondary subtype of MDD and an older age of onset predicted a significantly greater likelihood of relapse. Three or more prior episodes of depression predicted a significantly shorter time to the first and second prospectively observed relapses and, thus, a significantly greater likelihood of subsequent multiple affective episodes.
Energy Provision, Tissue Utilization, and Weight Loss in Prolonged Starvation
Authors: J. Runcie, T. E. Hilditch
Journal: BMJ (1974)

Daily weight loss measurements in 76 fasting, obese patients (58 females, 18 males) have shown a characteristic pattern of rapid loss initially (up to day 14) followed by a slower but uniform reduction in weight. There were significant sex differences. Measurements of tissue breakdown showed that the initial rapid weight loss was due to the continuing utilization by the nervous system of glucose derived from lean tissue. This requirement fell noticeably from the second week of starvation. Irreversible fluid elimination also contributed to the initial phase of rapid weight loss. Fat remained the primary source of energy throughout starvation and in established fasting (more than 14 days) contributed 96% of that requirement.
Adiposity of the Heart
Authors: Michael J. Zema
Journal: Annals of Internal Medicine (2006)

Letters3 October 2006Adiposity of the HeartMichael J. Zema, MDMichael J. Zema, MDFrom Brookhaven Memorial Hospital Medical Center, Patchogue, NY 11772Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-7-200610030-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: The review by McGavock and colleagues (1) probably incorrectly states that “overexpression of long-chain acyl-CoA synthetase, a key enzyme involved in triglyceride synthesis, produces an example of cardiac-restricted steatosis.” Long-chain acyl-CoA synthetase is an initial enzyme that is involved in fatty-acid β-oxidation and, after subsequent dehydrogenase and hydrolase reactions, results in formation of acetyl CoA. Upon formation, acetyl CoA usually enters the Krebs (citric acid) cycle for intracellular energy production. Alternatively, of course, these 2 carbon fragments may be resynthesized to fatty acids, such as palmitate, although the controlling intracellular signaling factors usually do not favor β-oxidation ...Reference1. McGavock JM, Victor RG, Unger RH, Szczepaniak LS. Adiposity of the heart, revisited. Ann Intern Med. 2006;144:517-24. [PMID: 16585666] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Brookhaven Memorial Hospital Medical Center, Patchogue, NY 11772Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAdiposity of the Heart*, Revisited Jonathan M. McGavock , Ronald G. Victor , Roger H. Unger , and Lidia S. Szczepaniak Adiposity of the Heart Gianluca Iacobellis and Arya M. Sharma Adiposity of the Heart Lidia S. Szczepaniak , Jonathan M. McGavock , Ronald G. Victor , and Roger H. Unger Adiposity of the Heart Bruce R. Leslie Adiposity of the Heart Balavenkatesh Kanna Metrics 3 October 2006Volume 145, Issue 7Page: 554KeywordsConflicts of interestDehydrogenasesEnzymesFatty acidsHeartLigasesMagnesiumPhosphatesSteatosis ePublished: 3 October 2006 Issue Published: 3 October 2006 CopyrightCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Detection of transient myocardial ischemia by computer analysis of standard and signal-averaged high-frequency electrocardiograms in patients undergoing percutaneous transluminal coronary angioplasty.
Authors: S Abboud, R J Cohen, A Selwyn, P Ganz, D Sadeh, P L Friedman
Journal: Circulation (1987)

Electrocardiographic manifestations of transient myocardial ischemia were studied, in 11 patients undergoing angioplasty (PTCA) of a left anterior descending coronary artery stenosis, by the visual inspection of the standard surface electrocardiogram (S-ECG) and the intracoronary ECG (IC-ECG) as well as computer-assisted analysis of the S-ECG. Cross-correlation analysis (CCA) performed by computer was used to compare beat-to-beat variability in ST-T morphology of the S-ECG during different stages of PTCA. CCA was also applied to the signal-averaged high-frequency QRS (SA-HFQ). All patients developed angina during balloon inflation, accompanied by transient marked ST-T changes in IC-ECG in 10 of 11 patients (90%). Visual inspection of S-ECG revealed transient ST-T changes in only 6 of 11 (54%). In contrast, CCA of the S-ECG revealed transient ST-T changes in 9 of 11 (82%). Analysis of SA-HFQ revealed that balloon inflation was associated with a marked reduction in the calculated root-mean-square (RMS) voltage for such signals (2.31 +/- 1.04 microV) as compared with RMS values before (3.27 +/- 1.12 microV, p less than .05) PTCA or after conclusion of PTCA (3.79 +/- 1.39 microV, p less than .01). Balloon inflation was also accompanied by changes in waveform morphology of the SA-HFQ, including the development of new or more prominent time zones of reduced amplitude in 10 of 11 individuals (90%). Such zones may represent slow conduction in regions of the heart rendered ischemic during PTCA. CCA of the S-ECG and of SA-HFQ appears to detect evidence of transient ischemia with greater sensitivity than simple visual inspection of S-ECG, and may therefore prove to be of use in the evaluation of patients with chest pain of uncertain origin.
Abstract IA9: Small RNA pathways in germline
Authors: Alexei A. Aravin
Journal: Cancer Research (2012)

Abstract In animals, a discrete class of small RNAs, the piwi-interacting RNAs (piRNAs), guard germ cell genomes against the activity of mobile genetic elements. piRNAs are generated, via an unknown mechanism, from apparently single-stranded precursors that arise from discrete genomic loci, termed piRNA clusters. Presently, little is known about the signals that distinguish a locus as a source of piRNAs. It is also unknown how individual piRNAs are selected from long precursor transcripts. To address these questions, we inserted new artificial sequence information into piRNA clusters and introduced these marked clusters as transgenes into heterologous genomic positions in mice and flies. Profiling of piRNA from transgenic animals demonstrated that artificial sequences were incorporated into the piRNA repertoire. Transgenic piRNA clusters are functional in non-native genomic contexts in both mice and flies, indicating that the signals that define piRNA generative loci must lie within the clusters themselves rather than being implicit in their genomic position. We found that both local and long-range sequence environments inform the generation of individual piRNAs from precursor transcripts. Citation Format: Alexei A. Aravin. Small RNA pathways in germline [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer; 2012 Jan 8-11; Miami Beach, FL. Philadelphia (PA): AACR; Cancer Res 2012;72(2 Suppl):Abstract nr IA9.
The Neuronal Transporter Gene SLC6A15 Confers Risk to Major Depression
Authors: Martin A. Kohli, Susanne Lucae, Philipp G. Saemann, Mathias V. Schmidt, Ayse Demirkan, Karin Hek, Darina Czamara, Michael Alexander, Daria Salyakina, Stephan Ripke, David Hoehn, Michael Specht, Andreas Menke, Johannes Hennings, Angela Heck, Christiane Wolf, Marcus Ising, Stefan Schreiber, Michael Czisch, Marianne B. Müller, Manfred Uhr, Thomas Bettecken, Albert Becker, Johannes Schramm, Marcella Rietschel, Wolfgang Maier, Bekh Bradley, Kerry J. Ressler, Markus M. Nöthen, Sven Cichon, Ian W. Craig, Gerome Breen, Cathryn M. Lewis, Albert Hofman, Henning Tiemeier, Cornelia M. van Duijn, Florian Holsboer, Bertram Müller-Myhsok, Elisabeth B. Binder
Journal: Neuron (2011)
Impact of organizational culture on preventability assessment of selected adverse events in the ICU: evaluation of morbidity and mortality conferences
Authors: Iris Pelieu, Juliette Djadi-Prat, Silla M. Consoli, Alain Cariou, Bertrand Guidet, Cécile You-Harada, Virginie Paget, Guillaume Héraud, Claire Lefur, Adeline Massin, Marlène Hennequin, Pierre Durieux, Jean-Yves Fagon, Christophe Faisy
Journal: Intensive Care Medicine (2013)