tbuckley/cabot-search huggingface dataset:
Falling Off the Edge
Authors: Sharon K. Inouye, James J. O’Connell, Margaret R. Puelle
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CERTAIN SOCIOCULTURAL AND ECONOMIC FACTORS INFLUENCING UTILIZATION OF STATE INSTITUTIONAL FACILITES IN INDIANA
Authors: JOHN I. NURNBERGER, M. ZUCKERMAN, J. A. NORTON, H. M. BRITTAIN
Journal: American Journal of Psychiatry (1961)

Indiana's 92 counties have been described in terms of certain social, cultural and economic variables. 1. Spearman Rank-Ordered Correlations of 6 of these variables justified the inclusion of 4 unit variables under a single composite category called the urbanization factor. 2. Net population change during the period 1950-1956 was isolated as a distinct variable which correlated at a low but consistent level with urbanization. No significant correlation was noted between a sensitive measure of county educational status (% of those aged 16 to 17 still enrolled in school) and the other social variables studied in the state at large. 3. Counties at the extremes of urbanization followed no recognized geographic patterns of distribution. Those counties extreme for negative population shift were generally located at the periphery of the state, while those showing maximum influx of population during the same period tended to be centrally located. 4. Counties with the highest percentage still enrolled in school were located in the northern half of the state, whereas, those showing lowest enrollment in school were distributed in the southern half of the state. 5. A similar north-south discrimination of counties at the extremes of economic status also was noted. 6. An analysis of the independent impact of urbanization on state hospital admission rates, presuming homogeneous distribution of equivalent resources, reveals no differences in admission rates for the 2 groups of counties at the extremes of urbanization. The lack of interaction here may well reflect the fact that the urbanization extremes studied are insufficiently extreme to reveal an independent influence of urbanization, as has been shown in certain previous studies. A similar analysis revealed no significant effect in those counties extreme for population mobility, but did indicate a significant inverse correlation between school enrollment and institutional admission rates. A separate reanalysis of the interaction of these social variables with admission rates for each mental hospital, and its admission zone as a geographic and institutional unit, revealed that zonal admission rates were correlated in highly individual and specific ways with zonal socioeconomic and educational characteristics. A generalization justified by these data is that certain common sociologic variables, even at the extremes of a normal distribution, will find significant expression in their impact on the level of utilization of the state mental institution, only in a highly specific context.
Association of a Common Single Nucleotide Polymorphism in the Trail-R1 Gene with Relapse-Free Survival in Rectal Cancer Patients
Authors: Guenter Hofmann, Tanja Langsenlehner, Florentine Moazedi-Fuerst, Sonja Kielhauser, Armin Gerger, Gudrun Absenger, Mathias Glehr, Joanna Szkandera, Hellmut Samonigg, Peter Krippl, Wilfried Renner
Journal: Annals of Oncology (2013)
β–sarcoglycan (A3b) mutations cause autosomal recessive muscular dystrophy with loss of the sarcoglycan complex
Authors: Carsten G. Bönnemann, Raju Modi, Satoru Noguchi, Yuji Mizuno, Mikiharu Yoshida, Emanuela Gussoni, Elizabeth M. McNally, David J. Duggan, Corrado Angelini, Eric P. Hoffman, Eijiro Ozawa, Louis M. Kunkel
Journal: Nature Genetics (1995)
Familial Adenomatous Polyposis: Should Patients Undergo Surveillance of the Upper Gastrointestinal Tract?
Authors: T. Sawada, T. Muto
Journal: Endoscopy (1995)

Upper gastrointestinal (UGI) endoscopy was performed in 35 asymptomatic patients with familial adenomatatous polyposis (FAP) to assess the prevalence of gastric and duodenal polyps and to demonstrate efficacy of endoscopic surveillance in patients with FAP. UGI polyps were found in 25 (71 %) of 35 polyposis patients. Among these, gastric fundic gland polyps were involved in seven patients, and UGI adenomas in 18 patients; there were nine gastric adenomas and 14 duodenal adenomas, including six cases of duodenal cancer. UGI polyps were found in 13 of 15 patients with extracolonic manifestations (87 %), but in only 12 of 20 patients (60 %) without. The median follow-up interval was 8.7 years in growing duodenal adenomas, but 3.5 years in adenomas without changes in size and number. It was concluded that surveillance gastroduodenoscopy every 3-5 years might be enough to treat duodenal adenomas by endoscopic mucosal resection.
RECENT PROGRESS IN MENTAL PHYSIOLOGY.
Authors: E. P. HURD
Journal: JAMA (1898)

It is unquestionably true that this century has witnessed greater advances in the knowledge of mental physiology than all the ages that have gone before. The nervous system and especially the cerebrum were, prior to this century, almost a<i>terra incognita.</i>We may not know more respecting the properties of mind than our forefathers did, but we understand as they could not the conditions of mental action. <h3>PHRENOLOGY.</h3> The movement inaugurated by Gall and Spurzheim early in this century undoubtedly added a powerful stimulus to the study of mind. The doctrine of localizations in the brain then first was given formal statement. Although the body of teaching comprised under the name of phrenology was erroneous, there was some truth which gave the system the success which it for a time attained. Attention was powerfully directed to the physical correlatives of mind and the so-called mental faculties were analyzed and defined
Reinduction of Atrial Fibrillation Immediately After Termination of the Arrhythmia Is Mediated by Late Phase 3 Early Afterdepolarization–Induced Triggered Activity
Authors: Alexander Burashnikov, Charles Antzelevitch
Journal: Circulation (2003)

Atrial fibrillation (AF) at times recurs immediately after termination of the arrhythmia. The mechanism(s) responsible for the extrasystole that reinduces AF is largely unknown. We hypothesized that abbreviation of action potential duration (APD) would permit very rapid rates of excitation, known to induce intracellular calcium loading, which in turn could promote delayed and/or early afterdepolarizations (EADs).Acetylcholine (ACh, 1 micromol/L) was used to abbreviate atrial APD and permit rapid-pacing induction of AF in isolated coronary-perfused canine right atria. Transmembrane action potentials, pseudo-ECG, and tension development were recorded. AF or rapid pacing was associated with an increase in tonic tension. Termination of AF or rapid pacing (cycle length, 150 to 80 ms) resulted in a dramatic rise of phasic tension, prolongation of repolarization of the initial beats at the regular rate (cycle length, 700 ms), and the development of late phase 3 EADs and extrasystoles. These extrasystoles initiated AF in 15 cases (involving 9 right atria) within the first 11 seconds after termination of AF or rapid pacing. This novel EAD mechanism is observed only in association with marked APD abbreviation. The calcium channel blocker nifedipine reduced, and the sarcoplasmic reticulum calcium release blocker ryanodine eliminated, the post-rapid pacing-induced increase in phasic tension, late phase 3 EADs, and extrasystoles that initiate AF.These data suggest that calcium overload conditions present after termination of vagally mediated AF contribute to the development of late phase 3 EAD-induced triggered activity and that this mechanism may be responsible for the extrasystolic activity that reinitiates AF.
A Lecture on the True First Stage of Consumption
Authors: H. Dobell
Journal: BMJ (1867)

RECENT advances in our knowledge of the natural history and pathology of tuberculosis have made it essential to an enlightened treatment of the disease, that we should no longer delay making a radical change in the nomenclature of its several stages.That which has heretofore been called the pre- monitory stage should, in my opinion, be at once re- cognised as the true first stage of consumption.*There is no doubt, that many scientific members of our profession have for some time past recognised
Gene Targeting with Viral Vectors
Authors: Paul C. Hendrie, David W. Russell
Journal: Molecular Therapy (2005)

Genetic manipulation of cells for scientific and therapeutic goals can be achieved by both gene-addition and gene-targeting methods. Gene targeting precisely alters a gene in its natural chromosome location, providing distinct advantages over gene-addition approaches. Classic gene-targeting delivery systems (microinjection, electroporation, or calcium phosphate transfection) have led to major scientific advances, but are too inefficient in their current state to be used for some applications, including gene therapy. This review describes the development of gene-targeting vectors based on three types of viruses (retrovirus, adenovirus, and adeno-associated virus) and discusses the design, possible mechanisms of action, and applications of gene-targeting vectors based on adeno-associated virus.
Inhibition of nasal polyp mast cell and eosinophil activation by desloratadine
Authors: M. L. Kowalski, A. Lewandowska, J. Wozniak, J. Makowska, A. Jankowski, L. DuBuske
Journal: Allergy (2004)

Nasal polyp tissue which contains mast cells and eosinophils is similar to the inflamed airway mucosa in cellular composition and mediator content. This investigation assessed the effect of desloratadine (DL), on activation of cells in nasal polyp tissue. Polyps were obtained from 22 patients with chronic rhinosinusitis [nine aspirin acetylosalitic acid (ASA)‐sensitive and 13 ASA‐tolerant]. Polyp tissue was dispersed by digestion, and preincubated with DL and incubated with anti‐immunoglobulin E (IgE) or calcium ionophore. LTC 4 , eosinophil cationic protein (ECP) and tryptase concentrations in supernatants were measured by immunoassays. Desloratadine (1, 10 and 50 μ M) inhibited calcium ionophore‐induced LTC 4 release by a mean of 29%, 50% and 63% respectively, and anti‐IgE‐induced LTC 4 release by a mean of 27%, 35% and 39% respectively. Calcium ionophore‐induced tryptase release was inhibited 60% and 69% by 10 and 50 μ M of DL, respectively, and anti‐IgE‐induced tryptase release was inhibited 33%, 47% and 66% for 1, 10 and 50 μ M of DL. Desloratadine 10 μ M and 50 μ M inhibited ECP release by and 45% and 48% respectively. Polyp tissue from ASA‐sensitive patients when compared with ASA‐tolerant patients released at baseline significantly more ECP (medians 120.0 μ g/ml, range: 69.0–182.0 vs 63.4 μ g/ml, range: 3.7–172.0; P &lt; 0.05), but similar amounts of tryptase and LTC 4 . This study demonstrated that DL inhibits activation of both eosinophils and mast cells derived from a site of airway mucosal inflammation.
Early management of spinal cord injury
Authors: P. K Plunkett, R G Wilkins, J D. Edwards
Journal: BMJ (1986)

sibility offuture spinal deformity, which can be the consequence of conservative management.Finally, it is our experience that after the early postoperative period the pain associated with the fracture is less with internally fixed spines than in those conservatively managed.No matter what hospital management is finally embarked on, the important aspect of the care of a potentially unstable spinal injury is, firstly, to recognise that this possibility exists and, secondly, to transport the patient without risking dis- placement of the spine by using the techniques described in the article.
Sun-bed-induced vesiculobullous polymorphic light eruption
Authors: E.O Toole, L. Barnes
Journal: British Journal of Dermatology (1995)

Journal Article Sun‐bed‐induced vesiculobullous polymorphic light eruption Get access E.O Toole, E.O Toole Department of Dermatology, St Jame's Hospital Dublin 8, Ireland Search for other works by this author on: Oxford Academic Google Scholar L. Barnes L. Barnes Department of Dermatology, St Jame's Hospital Dublin 8, Ireland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 132, Issue 1, 1 January 1995, Page 171, https://doi.org/10.1111/j.1365-2133.1995.tb08662.x Published: 01 January 1995
Children who sleep with light on may damage their sight
Authors: A. Tonks
Journal: BMJ (1999)

Small children and babies who sleep with the light on are more likely to grow up shortsighted than children who sleep in the dark, a team of US researchers reported last week.

A study of 479 children aged between 2 and 16 years shows that children who sleep with a room light on before the age of 2 are five times more likely be shortsighted than children who sleep in the dark. Night lights were also linked to …
Monitoring of the disease progress in Sézary syndrome by CD7<sup>−</sup> cells using flow cytometry
Authors: C. Collenberg, P. von den Driesch, M. Gramatzki, M. Fartasch, M.S. Gruschwttz
Journal: British Journal of Dermatology (1996)

Journal Article Monitoring of the disease progress in Sézary syndrome by CD7− cells using flow cytometry Get access C. Collenberg, C. Collenberg Department of Dermatology University of Erlangen‐Nuremberg, Hartmannstr. 14, 91052 Erlangen, Germany Search for other works by this author on: Oxford Academic Google Scholar P. von den Driesch, P. von den Driesch Department of Dermatology University of Erlangen‐Nuremberg, Hartmannstr. 14, 91052 Erlangen, Germany Search for other works by this author on: Oxford Academic Google Scholar M. Gramatzki, M. Gramatzki Division of Hematology/Oncology, Department of medicine III, University of Erlangen‐Nuremberg, Krankenhausstraß 12, 91052 Erlangen, Germany Search for other works by this author on: Oxford Academic Google Scholar M. Fartasch, M. Fartasch Department of Dermatology University of Erlangen‐Nuremberg, Hartmannstr. 14, 91052 Erlangen, Germany Search for other works by this author on: Oxford Academic Google Scholar M.S. Gruschwttz M.S. Gruschwttz Department of Dermatology University of Erlangen‐Nuremberg, Hartmannstr. 14, 91052 Erlangen, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 134, Issue 5, 1 May 1996, Pages 980–982, https://doi.org/10.1111/j.1365-2133.1996.tb06344.x Published: 01 May 1996
THE EFFECT OF THE ANGLE OF INCIDENCE UPON THE DOSE OF X-RAYS ABSORBED BY THE SKIN
Authors: E. H. MOLESWORTH, ARTHUR R. RIDDLE
Journal: British Journal of Dermatology (1935)

Journal Article THE EFFECT OF THE ANGLE OF INCIDENCE UPON THE DOSE OF X‐RAYS ABSORBED BY THE SKIN Get access E. H. MOLESWORTH, M.D.Sydney, E. H. MOLESWORTH, M.D.Sydney Search for other works by this author on: Oxford Academic Google Scholar ARTHUR R. RIDDLE, A.B., M.Sc.Cornell. ARTHUR R. RIDDLE, A.B., M.Sc.Cornell. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 47, Issue 4, 1 April 1935, Pages 152–160, https://doi.org/10.1111/j.1365-2133.1935.tb09847.x Published: 01 April 1935
Abnormal left ventricular intracavitary flow acceleration in patients undergoing aortic valve replacement for aortic stenosis. A marker for high postoperative morbidity and mortality.
Authors: G Aurigemma, S Battista, D Orsinelli, A Sweeney, L Pape, H Cuénoud
Journal: Circulation (1992)

We examined the clinical and echocardiographic characteristics of patients undergoing aortic valve replacement for aortic stenosis whose continuous wave Doppler studies showed abnormal intracavitary flow acceleration.The clinical and Doppler echocardiographic records of 53 consecutive patients undergoing aortic valve replacement for aortic stenosis were reviewed. Doppler echocardiography was performed at a mean of 6.6 days (range, 0-22 days) after surgery. Thirteen patients (group 1) had a dagger-shaped high-velocity systolic flow signal indicative of abnormal intracavitary flow acceleration on their postoperative Doppler study; group 2 comprised 40 aortic stenosis patients who underwent aortic valve replacement but had no postoperative evidence of abnormal intracavitary flow acceleration. Group 1 postoperative abnormal intracavitary flow velocities ranged from 1.8 to 6.8 m/sec (mean, 4.9 +/- 0.9 m/sec): Resulting dynamic gradients ranged from 10 to 184 mm Hg (mean, 104.6 +/- 32 mm Hg). Compared with group 2, group 1 patients had a distinctive ventricular geometry with more-pronounced hypertrophy, smaller cavities, and higher ejection fraction. Systolic anterior motion of the mitral valve did not accompany abnormal intracavitary flow acceleration in any patient. Six of 13 group 1 patients suffered postoperative hemodynamic compromise characterized by severe hypotension despite adequate pulmonary capillary wedge pressures; group 1 postoperative mortality was significantly greater than that seen in group 2 patients (38% versus 12%, p less than 0.05).Abnormal intracavitary flow acceleration after aortic valve replacement for severe aortic stenosis is associated with a distinctive ventricular geometry and supernormal systolic function but not systolic anterior motion of the mitral valve. Such flow acceleration appears to be a marker for increased postoperative morbidity and mortality. Preoperative and postoperative Doppler echocardiography may be useful in risk stratification and guiding therapy.
Effect of Cold Remedies on Metabolic Control of NIDDM
Authors: Homer J LeMar, William J Georgitis
Journal: Diabetes Care (1993)

OBJECTIVE To compare the effects of two cough syrup formulations (one with sugar and alcohol and one without) on the metabolic control of NIDDM. RESEARCH DESIGN AND METHODS A prospective, blinded cross-over study was performed at the Endocrinology Clinic of a U.S. Army Medical Center on 20 volunteers with NIDDM, treated with diet alone or diet plus an oral hypoglycemic agent. After a 7-day lead-in period, patients took 3-day courses of each cough syrup (10 ml 4 times/day) with an intervening 4-day wash-out period. Fasting and postprandial blood glucose and lipids before and immediately after each course were compared. RESULTS No differences in pretherapy and posttherapy values were found with either formula. Values taken after the sugar- and alcohol-containing formula were not different from those taken after the alcohol- and sugar-free formula. CONCLUSIONS We conclude that patients with NIDDM can take standard daytime cough formulas, in short courses of standard doses, without adverse effect on blood glucose or lipids.
Hidden Perforating Veins
Authors: D. E. Fitzgerald
Journal: BMJ (1970)

DBIATISOUNALincompetence never exhibit the distressing symptoms or show the gross lesions that are found in patients with incompetence of perforators just above the ankle.You state that it takes less than an hour to examine both legs by thermography and that this method can be extremely accurate, but you have omitted to state how effective is this method in detecting all incompetent perforators.Mr. K. D. Patil and colleagues (p.195) correctly detected 79 incompetent perforators in between 62 and 66 limbs, and
Expression and Regulatory Role of GAIP-Interacting Protein GIPC in Pancreatic Adenocarcinoma
Authors: Michael H. Muders, Shamit K. Dutta, Ling Wang, Julie S. Lau, Resham Bhattacharya, Thomas C. Smyrk, Suresh T. Chari, Kaustubh Datta, Debabrata Mukhopadhyay
Journal: Cancer Research (2006)

Abstract Regulator of G-protein signaling–GAIP-interacting protein COOH terminus (GIPC) is involved in protein trafficking, endocytosis, and receptor clustering and is associated with insulin-like growth factor I receptor (IGF-IR), a receptor important for proliferation and anchorage-independent growth. Here, we described GIPC expression in different human pancreatic adenocarcinoma (PCA) cell lines and we examined the role of GIPC in the regulation of IGF-IR protein levels in PCA. Interestingly, inhibition of GIPC expression by RNA interference led to reduced IGF-IR protein levels and a subsequent decrease in proliferation of PCA cells. We also determined that the PDZ domain of GIPC is essential for the post-translational regulation and the binding of IGF-IR. The importance of GIPC in pancreatic cancer development and progression is supported by tissue microarray data of 300 pancreatic cancer specimens where GIPC is highly expressed in PCA. Taken together, our data suggest that GIPC is a central molecule for the stability of IGF-IR and could be a target for future therapy. (Cancer Res 2006; 66(21): 10264-8)
1088-129 Does improvement of left ventricular ejection fraction in patients with viable myocardium persist over the long-term after coronary revascularization?
Authors: Vittoria Rizzello, Jeroen J Bax, Elena Biagini, Arend F.L Schinkel, Eleni C Vourvouri, Chiara Pedone, Gianfederico Possati, Filippo Crea, Jos R.T.C Roelandt, Don Poldermans
Journal: Journal of the American College of Cardiology (2004)
Levels of circulating IL-33 and eosinophil cationic protein in patients with hypereosinophilia or pulmonary eosinophilia
Authors: Hak-Ryul Kim, Chang-Duk Jun, Young-Jin Lee, Sei-Hoon Yang, Eun-Taik Jeong, Seok-Don Park, Do-Sim Park
Journal: Journal of Allergy and Clinical Immunology (2010)