Recurrent Stress Cardiomyopathy Induced by Sudafed PE
Authors: David M. Zlotnick, Armin Helisch
Journal: Annals of Internal Medicine (2012)

Letters17 January 2012Recurrent Stress Cardiomyopathy Induced by Sudafed PEDavid M. Zlotnick, MD and Armin Helisch, MDDavid M. Zlotnick, MDFrom Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756.Search for more papers by this author and Armin Helisch, MDFrom Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-2-201201170-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Sudafed PE (McNeil-PPC, Fort Washington, Pennsylvania) contains phenylephrine, whose predominant mechanism is to directly stimulate α-adrenergic receptors, leading to vasoconstriction. This medication can potentiate arrhythmia, hypertension, and myocardial infarction. It is becoming increasingly recognized that medications that act on the sympathetic nervous system can cause stress cardiomyopathy.Objective: To report a patient who developed recurrent stress cardiomyopathy after using Sudafed PE.Case Report: A 63-year-old woman with type 2 diabetes mellitus, hypertension, hyperlipidemia, and prior tobacco use went to the local hospital's emergency department for unremitting chest pain; she had new ST-segment elevations in leads I and aVL and ...References1. Dote K, Sato H, Tateishi H, Uchida T, Ishihara M. [Myocardial stunning due to simultaneous multivessel coronary spasms: a review of 5 cases]. J Cardiol. 1991;21:203-14. [PMID: 1841907] MedlineGoogle Scholar2. Bybee KA, Prasad A. Stress-related cardiomyopathy syndromes. Circulation. 2008;118:397-409. [PMID: 18645066] CrossrefMedlineGoogle Scholar3. Litvinov IV, Kotowycz MA, Wassmann S. Iatrogenic epinephrine-induced reverse Takotsubo cardiomyopathy: direct evidence supporting the role of catecholamines in the pathophysiology of the “broken heart syndrome”. Clin Res Cardiol. 2009;98:457-62. [PMID: 19513776] CrossrefMedlineGoogle Scholar4. Prasad A, Madhavan M, Chareonthaitawee P. Cardiac sympathetic activity in stress-induced (Takotsubo) cardiomyopathy. Nat Rev Cardiol. 2009;6:430-4. [PMID: 19471287] CrossrefMedlineGoogle Scholar5. Amariles P. A comprehensive literature search: drugs as possible triggers of Takotsubo cardiomyopathy. Curr Clin Pharmacol. 2011;6:1-11. [PMID: 21235467] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug-Induced Takotsubo CardiomyopathyCurrent Diagnostic and Treatment Strategies for Specific Dilated Cardiomyopathies: A Scientific Statement From the American Heart AssociationTakotsubo Cardiomyopathy Due to Systemic Absorption of Intraocular PhenylephrineThe Sympathetic Nervous System in the Pathogenesis of Takotsubo SyndromeTakotsubo cardiomyopathy induced by acute inhalation of hypochlorite drain gel exhalationsRecurrent takotsubo syndrome in a patient with myotonic dystrophy 1Physiology of the Aging Nose and Geriatric RhinitisDRESS Syndrome Associated with Deferasirox Treatment Recurrent Stress Cardiomyopathy Induced by Over-the-Counter Phenylephrine; Angular Cheilitis after Selective Serotonin Reuptake Inhibitor Treatment; Chemotherapy-Induced Spontaneous Orgasms; Liraglutide-Induced Acute Kidney Injury; Peripheral Edema Associated with Risperidone; Risk of Bleeding with Concurrent Use of Antibiotics and Warfarin 17 January 2012Volume 156, Issue 2Page: 171-172KeywordsCardiomyopathiesCatheterizationCoronary arteriesEmotionsHospitalizationsMyocardial infarctionSympathetic nervous systemTroponinUpper respiratory tract infections ePublished: 17 January 2012 Issue Published: 17 January 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...