tbuckley/cabot-search huggingface dataset:
Base-pair resolution DNA methylome of the EBV-positive Endemic Burkitt lymphoma cell line DAUDI determined by SOLiD bisulfite-sequencing
Authors: B Kreck, J Richter, O Ammerpohl, M Barann, D Esser, B S Petersen, I Vater, E M Murga Penas, C A Bormann Chung, S Seisenberger, V Lee Boyd, S Smallwood, H G Drexler, R A F MacLeod, M Hummel, F Krueger, R Häsler, S Schreiber, P Rosenstiel, A Franke, R Siebert
Journal: Leukemia (2013)

Base-pair resolution DNA methylome of the EBV-positive Endemic Burkitt lymphoma cell line DAUDI determined by SOLiD bisulfite-sequencing
Global prevalence of dementia: a Delphi consensus study
Authors: Cleusa P Ferri, Martin Prince, Carol Brayne, Henry Brodaty, Laura Fratiglioni, Mary Ganguli, Kathleen Hall, Kazuo Hasegawa, Hugh Hendrie, Yueqin Huang, Anthony Jorm, Colin Mathers, Paulo R Menezes, Elizabeth Rimmer, Marcia Scazufca
Journal: The Lancet (2005)
Mortality predictive capacity of the 6-min walk distance
Authors: G. G. Riario Sforza, C. Incorvaia
Journal: European Respiratory Journal (2008)

To the Editors: 

In a recent issue of the European Respiratory Journal we read with interest the article by Cote et al. 1 on the capacity of the 6-min walk distance to predict mortality in chronic obstructive pulmonary disease patients. We noted a striking difference between the cut-off value reported by Cote et al. 1, corresponding …
A glimpse into the future: a typical day in the NHS in the year 2050
Authors: H. Wilson
Journal: BMJ (2014)

Having completed the morning’s compulsory brain enhancing puzzles, I begin my ward round in the living room. Assessing patient A, via a video link with Singapore, I note dramatic improvement in mobility, set the computer to send hourly reports, and continue to my next patient in New York. Colleagues at the “global hospital” agree that this patient needs immediate surgery. The required robot is available that afternoon and we agree that Professor X, who is located in Washington, would be the most suited to perform this complex operation. He agrees to perform the surgery after he completes a regenerative neural transplant in Sydney; after all, the robot’s controls are located in his office at home.

I arrive at my …
Expression analysis of macrophage-derived chemokine (MDC/CCL22) gene in canine atopic dermatitis*1
Authors: T. Tsukui, S. Maeda, K. Ohmori, K. Masuda, K. Ohno, M. Sakaguchi, H. Tsujimoto, S. Iwabuchi
Journal: Journal of Allergy and Clinical Immunology (2004)
Detection of oxygen-derived free radical generation in the canine postischemic heart during late phase of reperfusion.
Authors: T Kuzuya, S Hoshida, Y Kim, M Nishida, H Fuji, A Kitabatake, M Tada, T Kamada
Journal: Circulation Research (1990)

To define the relation between oxygen-derived free radical (oxy-radical) generation in the reperfused ischemic myocardium and the progression of myocardial damage, we measured oxy-radical generation in the ischemic myocardium and the propagating infarct size in a model of canine coronary occlusion (90 minutes) and reperfusion. We used electron paramagnetic resonance spin-trapping techniques (5,5-dimethyl-1-pyrroline N-oxide [DMPO]) to detect oxy-radicals in the rapidly frozen myocardial samples taken by needle biopsy. There was no detectable generation of DMPO adducts in the normal myocardium before or after reperfusion. In the reperfused ischemic myocardium, electron paramagnetic resonance signals of DMPO-OOH (superoxide anion) and DMPO-OH (hydroxyl radical) were detected, with peak concentrations at 1 hour after reperfusion for DMPO-OOH and at 3 hours after reperfusion for DMPO-OH, respectively. These DMPO adducts were also detected during the early phase (15 seconds) of reperfusion, but the concentrations of these signals were much less than those during the late phase of reperfusion. Treatment with human recombinant superoxide dismutase (2.5 mg/kg/hr) and catalase (2.5 mg/kg/hr) during the course of experiments abolished DMPO-OOH formation but had little effect on DMPO-OH formation. Infarct size (percent of risk area infarcted), quantified by a dual staining method with Evans blue dye and triphenyltetrazolium chloride, was 18.3 +/- 4.8% (mean +/- SEM) at 90 minutes of occlusion. After 5 hours of reperfusion, infarct size increased to 43.6 +/- 7.2%. These results indicate that a greater magnitude of oxy-radical generation was sustained in the ischemic myocardial tissue during the late phase (1-3 hours) of reperfusion, associated with the progression of myocardial infarction. The concurrent appearance of oxy-radicals and progressive infarction may support the view that a chain reaction of oxy-radicals contributes to the propagation of myocardial cell damage in the postischemic heart.
Diuretics and Hypertension
Authors: O. D. Johnson, H. Ruchelman, Ralph V. Ford, Joan Bush
Journal: New England Journal of Medicine (1962)

THE diuretic-antihypertensive effect of the thiazide diuretics is well known.1 However, some investigators2 have stated that the antihypertensive effect of these compounds is greater than might be expected from their natriuretic action — that is, they possess antihypertensive properties in addition to being effective diuretics. The purpose of this study was to determine whether such an effect does exist.Materials and MethodsFive patients with hypertensive cardiovascular disease (not in congestive heart failure) were the subjects of this study. All previous medications used for the control of their hypertension were discontinued. They were maintained on a metabolic ward and given . . .
Raccoon Parasite an Emerging Health Concern
Authors: Joan Stephenson
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NMDA-induced neuronal survival is mediated through nuclear factor I-A in mice
Authors: Sika Zheng, Stephen M. Eacker, Suk Jin Hong, Richard M. Gronostajski, Ted M. Dawson, Valina L. Dawson
Journal: Journal of Clinical Investigation (2010)

Identification of the signaling pathways that mediate neuronal survival signaling could lead to new therapeutic targets for neurologic disorders and stroke. Sublethal doses of NMDA can induce robust endogenous protective mechanisms in neurons. Through differential analysis of primary library expression and microarray analyses, here we have shown that nuclear factor I, subtype A (NFI-A), a member of the NFI/CAAT-box transcription factor family, is induced in mouse neurons by NMDA receptor activation in a NOS- and ERK-dependent manner. Knockdown of NFI-A induction using siRNA substantially reduced the neuroprotective effects of sublethal doses of NMDA. Further analysis indicated that NFI-A transcriptional activity was required for the neuroprotective effects of NMDA receptor activation. Additional evidence of the neuroprotective effects of NFI-A was provided by the observations that Nfia(-/-) neurons were highly sensitive to NMDA-induced excitotoxicity and were more susceptible to developmental cell death than wild-type neurons and that Nfia(+/-) mice were more sensitive to NMDA-induced intrastriatal lesions than were wild-type animals. These results identify NFI-A as what we believe to be a novel neuroprotective transcription factor with implications in neuroprotection and neuronal plasticity following NMDA receptor activation.
CHANGES IN THE REACTION POTENTIAL OF A TRANSPLANTABLE TUMOR
Authors: Leonell C. Strong
Journal: The Journal of Experimental Medicine (1926)

A transplantable tumor, known as dBrD, gave very uniform results in a series of mice of known pedigree for a period of about a year. See PDF for Structure We may say that the reaction potential existing between the tumor and individuals inoculated was the same during this first part of the experiment. This tumor will grow in a mouse progressively provided there be present simultaneously at least from six to eight independently segregating genetic factors (genes) in the fundamental make-up of the host derived from the zygote that gave rise to the individual. In the course of routine transplantation of this tumor, there was a sudden change in this hitherto constant reaction potential resulting in at least three types of transplantable tumors-new types as far as their physiological activity and reaction potential are concerned. From a single original transplantable mass, I have therefore obtained four masses that remain true to type at least for some months of continued experimentation. These four types are (1) the original tumor, dBrD, still giving a six to eight Mendelian factor ratio, (2) dBrDm giving a two factor ratio, (3) dBrDBl showing another two factor ratio, and (4) dBrDBs giving a one factor ratio. The number of factors involved in the transplantability for the several tumors investigated are given in Table III.
Black Market Medicine
Authors: George L. Fite
Journal: JAMA (1967)

A wealthy banker once explained his success by having followed the adage, "To get rich, follow the money." Money in drug-making has its followers, and Kreig has put together this compendium of miscellany and backwash about the camp followers of the drug industry. Competition between drug manufacturers is not studied here. This competition has produced some mischief, resulting in strange differences between manufacturing cost and ultimate price to the consumer. The mischief still goes on, but Kreig is concerned with out-and-out bypassing food and drug laws by every device known to the criminally minded. These people are also following the money, but avoid work to earn it. The volume is an account of backalley dealings, largely undocumented, and of the same stature as the material in magazines which sell stories about sex, narcotics, pornography, and general evil, the more "popular" subjects of the newsstands. Doubtless the same stories could be
The Alternative Pathway of Complement — A System for Host Resistance to Microbial Infection
Authors: Douglas T. Fearon, K. Frank Austen
Journal: New England Journal of Medicine (1980)

THE alternative pathway of complement activation is that part of the complement system that can provide natural, nonimmune defense against microbial infection. In the early 1950's, Pillemer and his associates found that if a novel protein termed properdin (derived from the Latin verb perdere, "to destroy") was removed from human serum, certain serum bactericidal, virus-neutralizing, and hemolytic activities that appeared not to require antibody were impaired. These observations attracted great interest in the "properdin system" as a nonimmune mechanism for activating complement that was distinct from the antibody-dependent activation of the classical complement components Cl, C4, and C2. However, an . . .
An Empire of Ice: Scott, Shackleton, and the Heroic Age of Antarctic Science
Authors: Robert Root-Bernstein
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Combined-Modality Therapy of Cancer
Authors: Steven A. Rosenberg
Journal: New England Journal of Medicine (1985)

The three major methods of treatment for cancer are surgery, irradiation, and chemotherapy. Each has been shown to have considerable efficacy in the therapy of selected cancers, and each has its own advantages and toxic effects. It was realized early that the combined use of these approaches in a fashion carefully designed to optimize their advantages and interactions might produce better results than the use of any approach alone. Both practical and theoretical considerations made combined treatment attractive. When the complete surgical removal of a tumor involved loss of an extremity or of a nonvital organ, such as the rectum . . .
1064-186 Magnetic resonance imaging detected relationship between atherosclerotic plaques and shear stress in human descending thoracic aorta in vivo
Authors: Jolanda J Wentzel, Roberto Corti, Zahi A Fayad, Paul Wisdom, Frank Macaluso, Valentin Fuster, Juan J Badimon
Journal: Journal of the American College of Cardiology (2004)
Weight loss will be much faster in lean than in obese hunger strikers
Authors: I N Scobie
Journal: BMJ (1998)

EDITOR—Peel's editorial article on hunger strikers draws attention to an area of pathophysiology that few doctors will be familiar with.1 There is an extensive literature on the normal physiological response to fasting and pathological events that may occur during prolonged therapeutic starvation, a treatment for morbid obesity that has largely been abandoned because of lack of long term success …
A COMPARATIVE STUDY OF INTRAPULMONARY GAS MIXING AND FUNCTIONAL RESIDUAL CAPACITY IN PULMONARY EMPHYSEMA, USING HELIUM AND NITROGEN AS THE TEST GASES12
Authors: John B. Hickam, Regina Frayser
Journal: Journal of Clinical Investigation (1958)

gas, a study was also made of the effect of substituting nitrogen for helium as the test gas in this procedure. The present report describes the results of these studies. In general, the results confirm the suspicion that the Darling method can significantly underestimate the functional residual capacity in advanced emphysema and indicate that the values obtained by the helium method are not dependent upon special properties of the test gas.
Living with alkaptonuria
Authors: S. Laxon, L. Ranganath, O. Timmis
Journal: BMJ (2011)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Living with alkaptonuria Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Saving Medicare through Patient-Centered Changes — The Case of Injectables
Authors: Jeffrey S. Farroni, Leonard Zwelling, Jorge Cortes, Hagop Kantarjian
Journal: New England Journal of Medicine (2013)

Medicare covers the cost of injectable drugs only when they're administered in a hospital or physician's office, but considerations of convenience, cost, and quality all argue for encouraging patients to participate in their own care by allowing self-administration.
A Nationally Representative Case–Control Study of Smoking and Death in India
Authors: Prabhat Jha, Binu Jacob, Vendhan Gajalakshmi, Prakash C. Gupta, Neeraj Dhingra, Rajesh Kumar, Dhirendra N. Sinha, Rajesh P. Dikshit, Dillip K. Parida, Rajeev Kamadod, Jillian Boreham, Richard Peto
Journal: New England Journal of Medicine (2008)

The nationwide effects of smoking on mortality in India have not been assessed reliably.In a nationally representative sample of 1.1 million homes, we compared the prevalence of smoking among 33,000 deceased women and 41,000 deceased men (case subjects) with the prevalence of smoking among 35,000 living women and 43,000 living men (unmatched control subjects). Mortality risk ratios comparing smokers with nonsmokers were adjusted for age, educational level, and use of alcohol.About 5% of female control subjects and 37% of male control subjects between the ages of 30 and 69 years were smokers. In this age group, smoking was associated with an increased risk of death from any medical cause among both women (risk ratio, 2.0; 99% confidence interval [CI], 1.8 to 2.3) and men (risk ratio, 1.7; 99% CI, 1.6 to 1.8). Daily smoking of even a small amount of tobacco was associated with increased mortality. Excess deaths among smokers, as compared with nonsmokers, were chiefly from tuberculosis among both women (risk ratio, 3.0; 99% CI, 2.4 to 3.9) and men (risk ratio, 2.3; 99% CI, 2.1 to 2.6) and from respiratory, vascular, or neoplastic disease. Smoking was associated with a reduction in median survival of 8 years for women (99% CI, 5 to 11) and 6 years for men (99% CI, 5 to 7). If these associations are mainly causal, smoking in persons between the ages of 30 and 69 years is responsible for about 1 in 20 deaths of women and 1 in 5 deaths of men. In 2010, smoking will cause about 930,000 adult deaths in India; of the dead, about 70% (90,000 women and 580,000 men) will be between the ages of 30 and 69 years. Because of population growth, the absolute number of deaths in this age group is rising by about 3% per year.Smoking causes a large and growing number of premature deaths in India.
Pain and Enlargement of an Amputated-Leg Stump
Authors: Adolf Singer
Journal: JAMA (1984)

To the Editor.—  I believe the answer by Dr Milton Alter 1 of Temple University School of Medicine to the question raised under the above heading requires amplification.  The left common iliac artery ligation was performed 39 years ago. None of the nerves passing into the stump run close to this artery. In addition, it is inconceivable that the patient could have been suffering from  irritation for 39 years without the nerve becoming atrophied or the muscles wasted. I agree that the enlargement of the stump and buttock suggests recurrence or persistence of the arterial venous communications.  I advise against any injection of local anesthetic or steroids in this situation for two reasons. First, there really is no good evidence of the effectiveness of this technique in relieving symptoms due to so-called trigger points or stump neuromas. Second, there is considerable risk here of entering an abnormal vascular channel with
<i>Helicobacter pylori</i> Infection Induces Genetic Instability of Nuclear and Mitochondrial DNA in Gastric Cells
Authors: Ana Manuel Dantas Machado, Ceu Figueiredo, Eliette Touati, Valdemar Máximo, Sonia Sousa, Valérie Michel, Fátima Carneiro, Finn Cilius Nielsen, Raquel Seruca, Lene Juel Rasmussen
Journal: Clinical Cancer Research (2009)

Helicobacter pylori is a major cause of gastric carcinoma. To investigate a possible link between bacterial infection and genetic instability of the host genome, we examined the effect of H. pylori infection on known cellular repair pathways in vitro and in vivo. Moreover, various types of genetic instabilities in the nuclear and mitochondrial DNA (mtDNA) were examined.We observed the effects of H. pylori infection on a gastric cell line (AGS), on C57BL/6 mice, and on individuals with chronic gastritis. In AGS cells, the effect of H. pylori infection on base excision repair and mismatch repair (MMR) was analyzed by reverse transcription-PCR, Western blot, and activity assays. In mice, MMR expression was analyzed by reverse transcription-PCR and the CA repeat instabilities were examined by Mutation Detection Enhancement gel electrophoresis. Mutation spectra in AGS cells and chronic gastritis tissue were determined by PCR, single-stranded conformation polymorphism, and sequencing. H. pylori vacA and cagA genotyping was determined by multiplex PCR and reverse hybridization.Following H. pylori infection, the activity and expression of base excision repair and MMR are down-regulated both in vitro and in vivo. Moreover, H. pylori induces genomic instability in nuclear CA repeats in mice and in mtDNA of AGS cells and chronic gastritis tissue, and this effect in mtDNA is associated with bacterial virulence.Our results suggest that H. pylori impairs central DNA repair mechanisms, inducing a transient mutator phenotype, rendering gastric epithelial cells vulnerable to the accumulation of genetic instability and thus contributing to gastric carcinogenesis in infected individuals.
Comparison of Relapse and Treatment Failure Rates Among Patients With Neuromyelitis Optica
Authors: Maureen A. Mealy, Dean M. Wingerchuk, Jacqueline Palace, Benjamin M. Greenberg, Michael Levy
Journal: JAMA Neurology (2014)

Neuromyelitis optica (NMO) is an inflammatory disease of the optic nerves and spinal cord that leads to blindness and paralysis. Effective immunosuppression is the standard of care for relapse prevention.To compare the relapse and treatment failure rates among patients receiving the 3 most common forms of immunosuppression for NMO: azathioprine, mycophenolate mofetil, and rituximab.We performed a retrospective, multicenter analysis of relapses in 90 patients with NMO and NMO spectrum disorder treated with azathioprine, mycophenolate, and/or rituximab at the Mayo Clinic and the Johns Hopkins Hospital during the past 10 years.Annualized relapse rates.Rituximab reduced the relapse rate up to 88.2%, with 2 in 3 patients achieving complete remission. Mycophenolate reduced the relapse rate by up to 87.4%, with a 36% failure rate. Azathioprine reduced the relapse rate by 72.1% but had a 53% failure rate despite concurrent use of prednisone.Initial treatment with rituximab, mycophenolate, and, to a lesser degree, azathioprine significantly reduces relapse rates in NMO and NMO spectrum disorder patients. Patients for whom initial treatment fails often achieve remission when treatment is switched from one to another of these drugs.