Systemic Absorption of Enteral Vancomycin in a Patient with Pseudomembranous Colitis
Authors: PETER G. SPITZER
Journal: Annals of Internal Medicine (1984)

Brief Reports1 April 1984Systemic Absorption of Enteral Vancomycin in a Patient with Pseudomembranous ColitisPETER G. SPITZER, M.D., GEORGE M. ELIOPOULOS, M.D.PETER G. SPITZER, M.D., GEORGE M. ELIOPOULOS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-4-533 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOrally administered vancomycin has become the preferred mode of therapy for pseudomembranous colitis due to Clostridium difficile toxin (1). The popularity of this regimen is based, in part, on the general assumption that systemic absorption of the antibiotic from the intestine is "trivial" (2). We describe the case of a patient with pseudomembranous colitis and severe renal failure in whom enteral administration of vancomycin resulted in significant serum levels of the drug.A 62-year-old man was admitted to the New England Deaconess Hospital on 21 April 1983 for treatment of fecal impaction. The patient had a history of diabetes mellitus,...References1. FEKETYSILVAARMSTRONG RJJ. Treatment of antibiotic-associated enterocolitis with vancomycin. Rev Infect Dis. 1981;3(suppl):S273-81. CrossrefMedlineGoogle Scholar2. TEDESCOMARKHAMGURWITHCHRISTIEBARTLETT FRMDJ. Oral vancomycin for antibiotic-associated pseudomembranous colitis. Lancet. 1978;2:226-8. CrossrefMedlineGoogle Scholar3. FILBURNSHULLTEMPERADICK BVYJ. Evaluation of an automated fluorescence polarization immunoassay for vancomycin. Antimicrob Agents Chemother. 1983;24:216-20. CrossrefMedlineGoogle Scholar4. KROGSTADMOELLERINGGREENBLATT DRD. Single-dose kinetics of intravenous vancomycin. J Clin Pharmacol. 1980;20:197-201. CrossrefMedlineGoogle Scholar5. GRIFFITH R. Vancomycin: continued clinical studies. In: Antibiotics Annual, 1956-1957. New York: Medical Encyclopedia, Inc.; 1957:118-22. Google Scholar6. GERACIHEILMANNICHOLSWELLMANROSS JFDWG. Some laboratory and clinical experiences with a new antibiotic, vancomycin. Proc Staff Meet Mayo Clin. 1956;31:564-82. MedlineGoogle Scholar7. BRYANWHITE CW. Safety of oral vancomycin in functionally anephric patients. Antimicrob Agents Chemother. 1978;14:634-5. CrossrefMedlineGoogle Scholar8. COOKFERRAR FW. Vancomycin revisited. Ann Intern Med. 1978;88:813-8. LinkGoogle Scholar9. CUNHAQUINTILIANIDEGLINIZARDNIGHTINGALE BRJMC. Pharmacokinetics of vancomycin in anuria. Rev Infect Dis. 1981;3(suppl):S269-72. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New England Deaconess Hospital and Harvard Medical School Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByUncommon Case of Oral Vancomycin Neurotoxicity With Sexual DysfunctionNew Insights Into the Pharmacokinetics of Vancomycin After Oral and Intravenous Administration: An Investigation in Beagle DogsDoes oral vancomycin use necessitate therapeutic drug monitoring?Effective Dosage of Oral Vancomycin in Treatment for Initial Episode of Clostridioides difficile Infection: A Systematic Review and Meta-AnalysisAn Unusual Case of Ototoxicity with Use of Oral VancomycinSerum vancomycin concentrations after oral and intracolonic vancomycin administration in a patient with colonic discontinuity and severe Clostridium difficile infectionAn extremely high bioavailability of orally administered vancomycin in a patient with severe colitis and renal insufficiencyThe Effects of Fasting and Massive Diarrhea on Absorption of Enteral Vancomycin in Critically Ill Patients: A Retrospective Observational StudyGlycopeptidesA Prospective Pilot Study on the Systemic Absorption of Oral Vancomycin in Children With ColitisPseudomemberanous Colitis following Cesarean Delivery with Adjunctive Intracolonic VancomycinPharmacokinetics of LFF571 and Vancomycin in Patients with Moderate Clostridium difficile InfectionsRisk Factors for Systemic Vancomycin Exposure Following Administration of Oral Vancomycin for the Treatment of Clostridium difficile InfectionVancomycin pharmacokinetic models: informing the clinical management of drug-resistant bacterial infectionsGlycopeptidesOral Absorption of Enteral Vancomycin in a Child with Clostridium difficile Colitis and Renal ImpairmentSystemic Absorption from Oral Vancomycin: Check the Dose!Antibiotics for Gram-Positive Bacterial Infection: Vancomycin, Teicoplanin, Quinupristin/Dalfopristin, Oxazolidinones, Daptomycin, Telavancin, and CeftarolineSystemic absorption of oral vancomycin in patients with Clostridium difficile infectionOral vancomycin may have significant absorption in patients with Clostridium difficile colitisFaecal pharmacokinetics of orally administered vancomycin in patients with suspected Clostridium difficile infectionGlycopeptidesAntibiotic-Associated ColitisAntibiotics for Gram-Positive Bacterial Infections: Vancomycin, Teicoplanin, Quinupristin/Dalfopristin, Oxazolidinones, Daptomycin, Dalbavancin, and TelavancinTreatment of Clostridium difficile infection in older adultsSystemic absorption of oral vancomycin in a peripheral blood stem cell transplant patient with severe graft-versus-host disease of the gastrointestinal tractMaculopapular Rash Induced by Oral VancomycinCurrent and future treatment modalities for Clostridium difficile -associated diseaseVancomycin-Induced Elevation of Liver Enzyme LevelsSignificant Absorption of Oral Vancomycin in a Patient with Clostridium difficile Colitis and Normal Renal FunctionSystemic Absorption of Low-Dose Oral VancomycinOn the Prophylactic and Therapeutic Use of Danaparoid Sodium (Orgaran®) in Patients With Heparin-Induced ThrombocytopeniaAdjunctive Intracolonic Vancomycin for Severe Clostridium difficile Colitis: Case Series and Review of the LiteratureSystemic Vancomycin Overexposure in a Patient With Spinal Cord Injury Who Had Staphylococcal Sepsis and Clostridium difficile ColitisOral vancomycin hydrochloride therapy for postoperative methicillin-cephem-resistantStaphylococcus aureus enteritisThe value of Toxoplasma specific IgA in diagnosis.Systemic absorption of vancomycin.Possible Red-Man Syndrome Associated with Systemic Absorption of Oral Vancomycin in a Child with Normal Renal FunctionSystemic absorption after local intracolonic vancomycin in pseudomembranous colitisClinical Pharmacokinetics of Anti-InfectivesOral Vancomycin-Induced Rash: Case Report and Review of the LiteratureVancomycinTreatment of antibiotic-associated Clostridium difficile colitis with oral vancomycin: Comparison of two dosage regimensSystemic Absorption of Oral Vancomycin in Patients With Renal Insufficiency and Antibiotic-Associated ColitisVancomycin and the KidneyVancomycin: An UpdateVancomycin and necrotising enterocolitis.New Applications of Old AntimicrobialsAbsorption of VancomycinMICHAEL N. DUDLEY, PHARM, D., RICHARD QUINTILIANI, M.D., CHARLES H. NIGHTINGALE, PH.D., NANCY GONTARZ, B.S.Kolon und Rektum 1 April 1984Volume 100, Issue 4Page: 533-534KeywordsC difficile colitisClostridium difficileDiabetes mellitusDrug administrationDrugsHistory of medicineHospital medicineRenal failureToxinsVancomycin Issue Published: 1 April 1984 PDF DownloadLoading ...