Flutamide and Hepatitis
Authors: W. Hart, Bh. Ch. Stricker
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 June 1989Flutamide and HepatitisW. Hart, MD, PhD, BH. Ch. Stricker, MB, PhDW. Hart, MD, PhD, BH. Ch. Stricker, MB, PhDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-11-943_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Flutamide (4'-nitro-3'-trifluoromethyl-isobutyranilide is an antiandrogen without estrogenic, antiestrogenic, progestational, antiprogestational, androgenic, adrenocortical, and antigonadotropic activities. The drug is an anilide that appears to block the activity of dihydrotestosterone on androgen receptors in prostatic tissue. Jaundice after 1 to 3 months of flutamide therapy during clinical trials (1-3) and fatal liver failure in the setting of flutamide treatment have been reported (4), but, with one exception, no details were given. We report a case of cholestatic hepatitis associated with flutamide therapy.Transurethral prostatectomy was done in a 79-year-old man because of a poorly differentiated adenocarcinoma. Serum liver-enzyme and...References1. Johansson J, Andersson S, Beckman K, Lingardh G, and Zador G. Clinical evaluation of flutamide and estramustine as initial treatment of metastatic carcinoma of prostate. Urology. 1987;24:55-9. CrossrefGoogle Scholar2. Lund F and Rasmussen F. Flutamide versus stilboestrol in the management of advanced prostatic cancer: a controlled prospective study. Br J Urol. 1988;61:140-2. CrossrefMedlineGoogle Scholar3. Stegmayr B, Johansson J, and Schnürer L. Flutamide—an antiandrogen inhibiting prostatic cancer and prostatic secretion with retention of potency. Med Oncol Tumor Pharmacother. 1988;5:61-5. CrossrefMedlineGoogle Scholar4. Keating M, Griffin P, and Schiff S. Flutamide in the treatment of advanced prostate cancer [Abstract]. J Urol. 198;135:203A. Google Scholar5. Lundgren R. Flutamide as primary treatment for metastatic prostatic cancer. Br J Urol. 1987;59:156-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: W. Hart, MD, PhD; BH. Ch. Stricker, MB, PhD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReactive metabolites of the anticonvulsant drugs and approaches to minimize the adverse drug reactionPolycystic Ovary Syndrome and Hyperandrogenic StatesPolycystic Ovary Syndrome and Hyperandrogenic StatesInvolvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injuryStructural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United StatesAcute and fulminant hepatitis induced by flutamide: Case series report and review of the literatureIdiosyncratic Drug-Induced Liver Injury: Mechanisms and Susceptibility FactorsUnderlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicityThe risk of hepatotoxicity during long-term and low-dose flutamide treatment in hirsutismPolycystic Ovary Syndrome and Hyperandrogenic StatesInvolvement of Bile Salt Export Pump in Flutamide-Induced Cholestatic HepatitisHepatotoxicity Induced by Antiandrogens: A Review of the LiteratureAn update on bicalutamide in the treatment of prostate cancerFrequency of flutamide induced hepatotoxicity in patients with prostate carcinomaA Double-Blind, Placebo-Controlled, Crossover Trial of an Antiandrogen in the Treatment of Tourette's SyndromeAlteration by flutamide of neutrophil response to stimulationFulminant hepatic failure associated with bicalutamideTolerability of Nonsteroidal Antiandrogens in the Treatment of Advanced Prostate CancerFlutamide-induced toxic hepatitisFlutamide-induced liver toxicity including fatal hepatic necrosisFlutamide HepatotoxicityWorldwide activity and safety of bicalutamide: a summary reviewFlutamide HepatotoxicityFulminant hepatitis after flutamide treatmentDrug-induced hepatotoxicityNear Fatal Liver Dysfunction Secondary to Administration of Flutamide for Prostate CancerIncidence of liver toxicity associated with the use of flutamide in prostate cancer patientsSpontaneous Monitoring of Adverse Reactions to Drugs, Procedures, and Experiences in the NetherlandsFlutamide: An Antiandrogen for Advanced Prostate CancerEndocrine Disrupters, Steroidogenesis and Inflammation 1 June 1989Volume 110, Issue 11Page: 943-944KeywordsAdenocarcinomaAndrogensClinical trial reportingDrugsEstrogensHepatitisHepatitis ALiverProstatectomy ePublished: 1 December 2008 Issue Published: 1 June 1989 PDF downloadLoading ...