tbuckley/cabot-search huggingface dataset:
Clinical, dermoscopy and histological correlation study of melanotic pigmentations in excision scars of melanocytic tumours
Authors: R. Botella-Estrada, E. Nagore, J. Sopena, A. Cremades, A. Alfaro, O. Sanmartín, C. Requena, C. Serra-Guillén, C. Guillén
Journal: British Journal of Dermatology (2006)

Melanotic pigmentations in scars consecutive to the excision of melanocytic tumours can be secondary to a reactive phenomenon related to the scar tissue or to a recurrence of the melanocytic lesion excised in the first case. Recurrent naevi may sometimes adopt unusual features that make them difficult to differentiate from a melanoma.To describe the clinical, dermoscopic and histological features of melanotic pigmentations in scars consecutive to the excision of melanocytic tumours, and to correlate the histological diagnosis with the dermoscopic features.This was a prospective cohort study using macrophotography, dermoscopy and histopathological study. Ninety-five melanotic pigmentations (77 patients) in scars secondary to the excision of melanocytic tumours were prospectively collected in the Department of Dermatology at the Instituto Valenciano de Oncología in Valencia, Spain. Histopathological study was performed in 57 scars.Thirteen dermoscopic structures were identified. Four criteria allowed a differentiation between reactive and specific melanocytic pigmentations. Presence of globules and presence of heterogeneous pigmentation were features associated with specific melanocytic pigmentations (P < 0.0001). Presence of a regular network and presence of streaks were more frequently found in reactive pigmentations (P = 0.023 and 0.026, respectively).Dermoscopic examination of melanotic pigmentations in excision scars of melanocytic tumours provides useful information about the origin of that pigmentation. Based on such information, recurrent naevi can be differentiated from reactive pigmentations in most cases. Excision and histopathological diagnosis continue to be imperative in some cases of recurrent naevi with atypical clinical features.
Diarrhea of the Newborn
Authors: Stewart H. Clifford
Journal: New England Journal of Medicine (1947)

A REVOLUTIONARY change in social custom concerning childbirth has occurred during the past decade. Local evidence of this change is afforded by the statistics from the Boston Lying-in Hospital. This hospital delivers about 20 per cent of the infants born in Boston each year. The total number of babies delivered in this institution in 1935 and in 1945 was about the same: 4530 and 4685, respectively. In 1935 there were 1015 home deliveries in the outpatient department — in 1945 there were but forty-seven home deliveries, and in 1946 there were none.The virtual disappearance of home births was not . . .
Outbreaks of a Papulo-vesicular Exanthem on the Hands and Feet ("Summer-term Blains")
Authors: R. P. Warin, N. S. Galbraith, N. H. H. Golledge, S. P. Hall-Smith, A. E. K. Price, P. G. Mann, H. R. E. Wallis
Journal: BMJ (1964)

Biff=" 1413 by isotope dilution analysis than by gravimetric analysis when the patient is on penicillamine, possibly by exchange of the radioactive half-cystine residues, with the mixed disulphide pool.Polarographic analysis using the cobalt-ammonium method does not distinguish between penicillamine disulphide and cystine (F.L. Warren, private communication).Paper chromatography can be used to demonstrate the decrease in cystine output, but these results are only semi-quantitative.Harris and Robson (1957) have shown that some relatives of cystinuric patients excrete about 200 mg. of cystine per g.creatinine.These individuals, who are presumed to be hetero- zygous for the cystinuria gene, do not form calculi, and there- fore we did not think it necessary to reduce the cystine excre- tion of our patients below this level.Clayton and Patrick (1961) used penicillamine in the treat- ment of cystinosis in the Lignac-de Toni-Fanconi syndrome, and reported improved growth, reduction of the blood pyruvate level, and some decrease in the generalized aminoaciduria.Subsequent studies have suggested that the excess cystine was probably acting as an enzyme inhibitor in that disease (Patrick, 1962), and it is possible that the cystine was being removed by a disulphide exchange with penicillamine.In the case of cystinuria, D-penicillamine reduced the cystine excretion but did not affect the excretion of the basic amino-acids.The results reported in this paper confirm that it is possible substantially to reduce the urinary cystine output in cystinuria by oral administration of D-penicillamine for periods of up to one year without any evidence of decreasing effectiveness of the treatment, and that the treatment has been free of any long-term side-effects over this period.Summary D-Penicillamine has been used to reduce the urinary cystine excretion in seven cystinuric patients.No effect on the excretion of the basic amino-acids was observed.A diffuse morbilliform rash has been observed in three patients.This was controlled by steroid cover in the two patients to whom it was applied, and it was found possible to continue penicillamine therapy when the symptoms had subsided.Most of these patients have continued on penicillamine therapy for periods ranging from a few months up to one year.No further side-effects have developed and there has been no evidence of further stone formation.
Venereologists and distinction awards
Authors: F M Lanigan-O'Keeffe
Journal: BMJ (1976)

different order.Such false-positive reactions will not, of course, explain the fact that 36 out of the 37 patients reported by Dr Solomon and Miss Macaulay did not respond to test doses of aspirin.Only one of their patients had an immediate response (type 1) to candida antigen and I wonder if any had a type 3 response, as it was this type which occurred in 25 out of the 36 patients reacting to candida in our series."I look forward to hearing further details about the tests and the further experience of Dr Solomon and Miss Macaulay.I do wish them every success in their work in this field.
Role of Kozak sequence polymorphism of platelet glycoprotein Ibα as a risk factor for coronary artery disease and catheter interventions
Authors: Christian Meisel, Vahid Afshar-Kharghan, Ingolf Cascorbi, Michael Laule, Verena Stangl, Stefan B Felix, Gert Baumann, José A López, Ivar Roots, Karl Stangl
Journal: Journal of the American College of Cardiology (2001)
Community care: the first year
Authors: A K Stanley, J F MacMillan
Journal: BMJ (1994)

EDITOR, - Trish Groves reports on mental health care in Bassetlaw one year into the Community Care Act, referring to people with enduring mental health problems and the importance of rehabilitation.1 There is no mention of finding community placement for the most disabled group of long stay chronic psychotic patients.

Latimer House is a nursing home in West Birmingham, set up under …
Mapping of Pain Phenotypes in Female Patients with Bladder Pain Syndrome/Interstitial Cystitis and Controls
Authors: Dean A. Tripp, J. Curtis Nickel, Jennifer Wong, Michel Pontari, Robert Moldwin, Robert Mayer, Lesley K. Carr, Ragi Doggweiler, Claire C. Yang, Nagendra Mishra, Jorgen Nordling
Journal: European Urology (2012)
Gene-target recognition among members of the Myc superfamily and implications for oncogenesis
Authors: Rónán C. O'Hagan, Nicole Schreiber-Agus, Ken Chen, Gregory David, Jeffrey A. Engelman, Richard Schwab, Leila Alland, Cole Thomson, Donald R. Ronning, James C. Sacchettini, Paul Meltzer, Ronald A. DePinho
Journal: Nature Genetics (2000)
THE THREAT OF AMEBIASIS IN THE FOOD HANDLER
Authors: FRED O. TONNEY
Journal: JAMA (1933)

In the light of the very disquieting experience here recounted, which is the second of its kind occurring in a large metropolitan center within a few years, one clearly defined fact is apparent—that too little thought has been given to amebiasis as a public health hazard in the United States. Although several published surveys,<sup>1</sup>have called attention to the growing incidence of infestation with Endamoeba histolytica in this country, giving evidence that from 3 to 10 per cent of the populations studied were infested with this parasite, the general impression still prevails that the disease is mostly confined to tropical and subtropical regions and is of little concern in the temperate zones. However, two recent outbreaks of amebic dysentery in large urban hotels—the last numbering thirty-one clinically active cases and eleven carriers of the encysted parasite at the time of the first examination, with a number of unexplained cases
Central command increases sympathetic nerve activity during spontaneous locomotion in cats.
Authors: G Hajduczok, J S Hade, A L Mark, J L Williams, R B Felder
Journal: Circulation Research (1991)

A controversial issue in exercise physiology is the relative contribution of central command versus afferent input from contracting muscles and baroreceptors in the regulation of sympathetic nerve activity (SNA) during exercise. Recent studies of exercising humans have suggested that central command increases cutaneous sympathetic sudomotor nerve activity but have challenged the concept that central command contributes importantly to increases in sympathetic vasoconstrictor nerve activity to skin and skeletal muscle. The purpose of this study was to examine the influence of central command on renal SNA and lumbar SNA during spontaneous locomotion in decorticate cats. Unanesthetized decorticate cats that developed locomotion spontaneously or during electrical stimulation of the subthalamic locomotor region were studied in the presence and absence of input from skeletal muscle and baroreceptor afferents. Spontaneous rhythmic locomotion in the unparalyzed state was associated with significant increases in mean arterial pressure (MAP) from 106 +/- 10 to 133 +/- 11 mm Hg (p less than 0.05) and increases in renal SNA of 301 +/- 100% (p less than 0.05). During spontaneous fictive rhythmic locomotion in paralyzed cats, there were also significant (p less than 0.05) increases in MAP (43 +/- 6%), renal SNA (183 +/- 32%), and lumbar SNA (223 +/- 83%). Baroreceptor denervation did not attenuate increases in MAP, renal SNA, and lumbar SNA during locomotion. During electrical stimulation of the subthalamic locomotor region in paralyzed cats, MAP increased by 43 +/- 17% (p less than 0.05), and renal SNA increased by 175 +/- 47% (p less than 0.05). These findings indicate that central command is capable of increasing sympathetic neural drive in unanesthetized decorticate cats. This increase in sympathetic drive occurs even in the absence of feedback from contracting muscles or from arterial and cardiopulmonary baroreceptors.
Spontaneous Renal Decapsulation with Excessive Fluid Leakage after Transplantation
Authors: Robert A. Koene, Stephen H. Skotnicki, Frans M. Debruyne
Journal: New England Journal of Medicine (1979)

SURGICAL complications rarely occur late after renal transplantation. We have seen two patients with presumably spontaneous decapsulation of the kidney even while the grafts had excellent renal function. The decapsulation led to excessive fluid loss from the kidney surface.Case ReportsCase 1. Five years after transplantation a large and painful swelling suddenly developed at the site of grafting in a 30-year-old man. Ascites developed on the next day. Peritoneal drainage resulted in fluid production ranging from 4 to 12 liters per day. Examination of the fluid showed that the total protein was 0.1 to 0.2 g per 100 ml, . . .
A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors
Authors: Jeffrey Wyckoff, Weigang Wang, Elaine Y. Lin, Yarong Wang, Fiona Pixley, E. Richard Stanley, Thomas Graf, Jeffrey W. Pollard, Jeffrey Segall, John Condeelis
Journal: Cancer Research (2004)

Abstract Invasion of tumor cells into the surrounding connective tissue and blood vessels is a key step in the metastatic spread of breast tumors. Although the presence of macrophages in primary tumors is associated with increased metastatic potential, the mechanistic basis for this observation is unknown. Using a chemotaxis-based in vivo invasion assay and multiphoton-based intravital imaging, we show that the interaction between macrophages and tumor cells facilitates the migration of carcinoma cells in the primary tumor. Gradients of either epidermal growth factor (EGF) or colony-stimulating factor 1 (CSF-1) stimulate collection into microneedles of tumor cells and macrophages even though tumor cells express only EGF receptor and macrophages express only CSF-1 receptor. Intravital imaging shows that macrophages and tumor cells migrate toward microneedles containing either EGF or CSF-1. Inhibition of either CSF-1– or EGF-stimulated signaling reduces the migration of both cell types. This work provides the first direct evidence for a synergistic interaction between macrophages and tumor cells during cell migration in vivo and indicates a mechanism for how macrophages may contribute to metastasis.
Hormone Therapy Use and Risk of Ovarian Cancer—Reply
Authors: Lina Steinrud Mørch
Journal: JAMA (2009)

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TREATMENT OF INDUSTRIAL ACCIDENTS TO THE KNEE-JOINT
Authors: R. WALLACE BILLINGTON
Journal: JAMA (1922)

besides those of mental torticollis.There are cases caused by lesions in the striate apparatus.They are to be found abundantly in postencephalitic dystonias.Many patients with encephalitis have dyskinesias.Those are due to distinct lesions which can be demonstrated postmortem.The paper discussed especially the states which Dr. Patrick so beau¬ tifully illustrated when he said, illustrating the return of the twisted neck, by means of the approach of the forefinger, 'What is the pathology of that?"It is a psychic pathology.Many of these movements (those we term psychasthenic movements) are influenced by psychologic means.It is true that many of these tics are incurable by our present means, because they are incorporated into the personality.In them the tic is the patient's life, so to speak; without it he is lost.Unless one can change that patient's whole attitude of looking at things, one cannot cure the tic.Those are the difficult cases spoken of in the last paragraph of my paper.Most cases are not so difficult and they can be cured, some by changing the patient's attitude to life, some by a series of exercises.The question arises in cases of tic as to the physician's personality.It is a great trouble to correct the condition in some patients.I myself cannot do it in cases of long standing.Some men can.What I read the paper for \vas not so much to draw attention to the inadvisability of oper¬ ating in cases of torticollis as to call attention to other dyskinesias, writers' and other cramps of occupation and the like, which are fundamentally psychogenic, tics, and to which the same principles apply as those which we have tried to speak of in torticollis.The cases which are cured by operation can be cured more easily another way.When surgical measures do by chance cure the patient, it is not the operation, but the suggestion given thereby which affects the patient.Such patients can easily be cured in the same way as the cases I described, sometimes in one interview, by changing the patient's attitude toward his disability.These are the cases that are not difficult.In the difficult cases, it is a question of whether to undertake treatment or to leave them as they are.
Probable visualization of the elusive hepatitis C virus Takahashi K, Kishimoto S, Yoshizawa H, Okamoto H, Yoshikawa A, Mishro S. p26 Protein and 33-nm particle associated with nucleocapsid of hepatitis C virus recovered from the circulation of infected hosts. Virology 1992; 191: 431–434
Authors: H Alter
Journal: Hepatology (1993)
Estimation of Tc-99m MAG3 Clearance Using Camera-Based Methods Without Blood Sampling
Authors: Yusuke Inoue, Kuni Ohtomo
Journal: Clinical Nuclear Medicine (2011)

To establish camera-based methods for estimating Tc-99m mercaptoacetyltriglycine (MAG3) clearance without blood sampling.The results of renal scintigraphy with Tc-99m MAG3 obtained from 160 patients were analyzed retrospectively. Eight renogram parameters were calculated for each patient based on the area under the renogram (area method) and slope of the renogram (slope method) using different periods for analysis (1-2 and 1-2.5 minutes for the area method; 0.5-1.5 and 0.5-2 minutes for the slope method) and different backgrounds for subtraction (perirenal and subrenal backgrounds). The 8 parameters were then correlated with MAG3 clearance measured by the single-sample methods proposed by Russell et al and Bubeck et al to determine the equation for the conversion of renogram parameters to clearance.All 8 renogram parameters were highly correlated with clearance measured by the single-sample methods, and the obtained equations enabled the estimation of clearance from image data. Selection between the area and slope methods, between different periods for analysis, or between perirenal and subrenal backgrounds did not cause large differences in the estimation.The camera-based methods determined in the present study allow the estimation of MAG3 clearance with acceptable accuracy.
IRS2 Signaling in LepR-b Neurons Suppresses FoxO1 to Control Energy Balance Independently of Leptin Action
Authors: Marianna Sadagurski, Rebecca L. Leshan, Christa Patterson, Aldo Rozzo, Alexandra Kuznetsova, Josh Skorupski, Justin C. Jones, Ronald A. Depinho, Martin G. Myers, Morris F. White
Journal: Cell Metabolism (2012)
Malignant transformation of anal skin tags in Crohn's disease.
Authors: K W Somerville, M J Langman, D J Da Cruz, T W Balfour, L Sully
Journal: Gut (1984)

The anal skin tags of a young man with ileal and perianal Crohn9s disease underwent malignant transformation. This was not associated with immunosuppressive drug therapy and has not been previously described.
<i>Chlamydia psittaci</i> infection and clinicopathologic analysis of ocular adnexal lymphomas in Korea
Authors: Changhoon Yoo, Min‐Hee Ryu, Jooryung Huh, Ji Hyun Park, Hye Jin Kang, Hyo Sook Ahn, Yongjae Lee, Myoung Joon Kim, Hyoungnam Lee, Tae Won Kim, Heung Moon Chang, Jae‐Lyun Lee, Yoon‐Koo Kang
Journal: American Journal of Hematology (2007)

Abstract Ocular adnexal lymphoma (OAL) is a mostly extranodal marginal zone lymphoma (EMZL). Recent findings have suggested an association between Chlamydia psittaci (Cp ) infection and OAL. We sought to confirm this issue and to analyze the clinicopathologic characteristics of OAL in Korea. Between 1993 and 2004, 33 OAL cases were identified at the Asan Medical Center, Seoul, Korea. DNA was extracted from paraffin‐embedded tissues, and touchdown enzyme time release polymerase chain reaction was performed to identify three Chlamydia species ( Cp, C. tracomatis, and C. pneumoniae ). The same procedures were also performed in 21 samples from patients with non‐neoplastic ocular adnexal disease (NNOAD). All OAL cases were EMZL. Cp DNA was detected in 26/33 (79%) OAL samples compared with 5/21 (23%) NNOAD samples ( P &lt; 0.001). With a median follow‐up of 38.5 months (range: 1–105 months), the 5‐year progression‐free survival (PFS) and overall survival (OS) rates of OAL patients were 72% and 93%, respectively. Clinicopathologic characteristics, recurrence rate, PFS, and OS were not associated with Cp infection. Our study demonstrates an association between OAL and Cp infection in Korea, suggesting that Cp plays a role as a causative antigen in Korean OAL patients. Am. J. Hematol., 2007. © 2007 Wiley‐Liss, Inc.
Expression of osteopontin in chronic rhinosinusitis with and without nasal polyps
Authors: X. Lu, X. H. Zhang, H. Wang, X. B. Long, X. J. You, Q. X. Gao, Y. H. Cui, Z. Liu
Journal: Allergy (2008)

Background: Osteopontin (OPN) is a multifunctional 34‐kDa extracellular matrix protein that can influence the inflammatory process. However, the presence of OPN in human sinonasal mucosa and its roles in the inflammatory process of chronic rhinosinusitis (CRS) are not clear. This study investigated the expression of OPN in human sinonasal mucosa, its cytokine‐driven expression regulation, and its effect on cytokine production in sinonasal mucosa. Methods: Surgical samples were investigated by means of quantitative reverse transcriptase polymerase chain reaction for evaluation of OPN messenger RNA (mRNA) expression, and the presence and location of OPN protein expression were analyzed using immunohistochemistry. Furthermore, nasal explant culture was used to investigate the mutual regulatory interactions between interferon (IFN)‐γ, interleukin (IL)‐4, IL‐5, IL‐13, IL‐1β, and tumor necrosis factor (TNF)‐α and OPN in sinonasal mucosa. Results: Osteopontin expression was significantly upregulated in CRS tissues compared with control tissues. There was a further significant increase of OPN expression in patients with nasal polyps (NPs) and asthma. Immunohistochemistry revealed positive staining of OPN in epithelial cells, submucosal glands, infiltrating cells, and extracellular matrix. Osteopontin mRNA was induced by IFN‐γ, IL‐1β, and TNF‐α, but inhibited by IL‐4 and IL‐13. On the contrary, OPN induced IFN‐γ, IL‐4, IL‐5, IL‐13, IL‐1β, and TNF‐α production in sinonasal mucosa. Conclusions: The expression of OPN is upregulated in CRS. The mutual regulatory interactions between OPN and inflammatory cytokines suggest that OPN may play an important role in the pathogenesis of CRS.
Induction Chemotherapy, Extrapleural Pneumonectomy, and Postoperative High-Dose Radiotherapy for Locally Advanced Malignant Pleural Mesothelioma: A Phase II Trial
Authors: Raja M. Flores, Lee M. Krug, Kenneth E. Rosenzweig, Ennapadam Venkatraman, Alain Vincent, Robert Heelan, Tim Akhurst, Valerie W. Rusch
Journal: Journal of Thoracic Oncology (2006)