Amylase in Diagnosis of Pancreatic Disease
Authors: J. EDWARD BERK
Journal: Annals of Internal Medicine (1978)

Editorials1 June 1978Amylase in Diagnosis of Pancreatic DiseaseJ. EDWARD BERK, M.D., M.A.C.P.J. EDWARD BERK, M.D., M.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-6-838 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA recent major advance in the diagnostic use of amylase in pancreatic disease is the so-called isoamylase analysis (1). Using various methods (chiefly electrophoresis, isoelectric focusing, and column chromatography), one can identify two major and a variable number of minor amylase peaks in human serum and urine (1, 2). The major peak in serum and urine corresponds in mobility or isoelectric position with the principal amylase peak found in purified human pancreatic extract using similar methods of study; this peak has been designated "P-type." The major peak that corresponds in position to the principal peak found in parotid gland or...References1. BERKFRIDHANDLERMONTGOMERY JLK: Isoamylase analysis: methods and clinical application, in Developments in Digestive Disease: Clinical Relevance (1), edited by BERK JE. Philadelphia, Lea & Febiger, 1977, pp. 133-152 Google Scholar2. WARSHAWLEE AK: Characteristic alterations of serum isoenzymes of amylase in diseases of the liver, pancreas, salivary gland, lung, and genitalia. J Surg Res 22:362-369, 1977 CrossrefMedlineGoogle Scholar3. O'DONNELLFITZGERALDMCGEENEY MOK: Differential serum amylase determination by use of an inhibitor, and design of a routine procedure. Clin Chem 23:560-566, 1977 CrossrefMedlineGoogle Scholar4. WARSHAWFULLER AA: Specificity of increased renal clearance of amylase in diagnosis of acute pancreatitis. N Engl J Med 292:325-328, 1975 CrossrefMedlineGoogle Scholar5. JOHNSONELLISLEVITT SCM: Mechanism of increased renal clearance of amylase/creatinine in acute pancreatitis. N Engl J Med 295:1214-1217, 1976 CrossrefMedlineGoogle Scholar6. BERKFRIDHANDLER JL: Advances in the interpretation of hyperamylasemia, in Progress in Gastroenterology, edited by GLASS GBJ. New York, Grune and Stratton, 1977, pp. 873-894 Google Scholar7. LEVINEGLAUSERBERK RFJ: Enhancement of the amylase-creatinine clearance ratio in disorders other than acute pancreatitis. N Engl J Med 292:329-332, 1975 CrossrefMedlineGoogle Scholar8. BERGERCOWLINTURNER GJT: Amylase: creatinine clearance ratio and urinary excretion of lysozyme in acute pancreatitis and acute duodenal perforation. S Afr Med J 50:1559-1561, 1976 MedlineGoogle Scholar9. BINDRICHDURRBODE DHJ: The frequency of macroamylasemia and the diagnostic value of the amylase clearance/creatinine clearance ratio. Verh Dtsch Ges Inn Med 82:954-956, 1977 Google Scholar10. LEVITTJOHNSONELLISENGEL MSCR: Influence of amylase assay technique on renal clearance of amylase-creatinine ratio. Gastroenterology 72:1260-1263, 1977 CrossrefMedlineGoogle Scholar11. SHIMAMURAFRIDHANDLERBERK JLJ: Specific detection of abnormally high levels of pancreatic isoamylase in urine (abstract). Clin Res 23:256A, 1975 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of California Irvine Medical Center Orange, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAkute PankreatitisAkute PankreatitisHow Much Can We Know About Acute Pancreatitis?STUART JON SPECHLER, M.D.Diagnostic Value of Routine Isoamylase Assay of Hyperamylasemic SerumThe Diagnosis of Exocrine Pancreatic Disease: The Present Position ReviewedHyperamylasemia in Diabetic Ketoacidosis: Sources and SignificanceFRANK VINICOR, M.D., LARRY M. LEHRNER, M.D., Ph.D., ROBERT C. KARN, Ph.D., A. DONALD MERRITT, M.D. 1 June 1978Volume 88, Issue 6Page: 838-839KeywordsChromatographyPancreatic diseasesParotid glandsUrine Issue Published: 1 June 1978 PDF DownloadLoading ...