tbuckley/cabot-search huggingface dataset:
Implications of the Failure to Identify High-Risk Electrocardiogram Findings for the Quality of Care of Patients With Acute Myocardial Infarction
Authors: Frederick A. Masoudi, David J. Magid, David R. Vinson, Albert J. Tricomi, Ella E. Lyons, Laurie Crounse, P. Michael Ho, Pamela N. Peterson, John S. Rumsfeld
Journal: Circulation (2006)

Background— The impact of misinterpretation of the ECG in patients with acute myocardial infarction (AMI) in the emergency department (ED) setting is not well known. Our goal was to assess the prevalence of the failure to identify high-risk ECG findings in ED patients with AMI and to determine whether this failure is associated with lower-quality care. Methods and Results— In a retrospective cohort study of consecutive patients presenting to 5 EDs in California and Colorado from July 1, 2000, through June 30, 2002, with confirmed AMI (n=1684), we determined the frequency of the failure by the treating provider to identify significant ST-segment depressions, ST-segment elevations, or T-wave inversions on the presenting ECG. In multivariable models, we assessed the relationship between missed high-risk ECG findings and evidence-based therapy in the ED after adjustment for patient characteristics and site of care. High-risk ECG findings were not documented in 201 patients (12%). The failure to identify high-risk findings was independently associated with a higher odds of not receiving treatment among ideal candidates for aspirin (odds ratio [OR], 2.13; 95% confidence interval [CI], 1.51 to 2.94), β-blockers (OR, 1.85; 95% CI, 1.14 to 3.03), and reperfusion therapy (OR, 7.69; 95% CI, 3.57 to 16.67). Among patients with missed high-risk ECG findings, in-hospital mortality was 7.9% compared with 4.9% among those without missed findings ( P =0.1). Conclusions— The failure to identify high-risk ECG findings in patients with AMI results in lower-quality care in the ED. Systematic processes to improve ECG interpretation may have important implications for patient treatment and outcomes.
Some characteristics of human red blood cells separated according to their size: A comparison with density‐fractionated red blood cells
Authors: Jenny Vaysse, Roger Vassy, Virginie Eclache, Liliane Gattegno, Dominique Bladier, Paul Pilardeau
Journal: American Journal of Hematology (1988)

Abstract During their in vivo ageing, red blood cells (RBC) increase in density and become smaller. Age‐defined RBC subpopulations are usually collected by centrifugation. A fractionation according to RBC volume has been proposed as an improved alternative to such age separation. Because a few data reported in the literature indicate some discrepancies between the two methods, blood samples were separated either by centrifugation or by counterflow centrifugation, and some characteristics of the RBC thus fractionated were studied. The enzyme activities decrease either when the density rises or when the volume (MCV) decreases. However, the comparison of other RBC characteristics strongly suggests that these two procedures do not lead to the collection of the same RBC subpopulations: for instance, the hemoglobin content increases when the MCV rises, whereas it remains constant whatever the RBC density is. With radiolabelled cells, it is shown 1) that the most dense RBC are recovered in all the size‐separated RBC subpopulations, even though they tend to concentrate in the fractions with the largest MCV, and 2) that the smallest RBC are almost fairly distributed in all the RBC subpopulations, whatever their density, whereas the largest RBC are mainly, but not exclusively, present in the high‐density fractions. Thus, fractionation according to size does not match separation according to density. Taken together with results from in vivo experiments carried out in mice and with the fact that reticulocytes are present in all the size‐separated fractions, these data suggest that counterflow centrifugation may be a very questionable procedure to achieve a RBC fractionation according to age and therefore that RBC volume might not be a reliable criterion of RBC age.
Implementing glucose control in intensive care: a multicenter trial using statistical process control
Authors: Saeid Eslami, Ameen Abu-Hanna, Nicolette F. de Keizer, Rob J. Bosman, Peter E. Spronk, Evert de Jonge, Marcus J. Schultz
Journal: Intensive Care Medicine (2010)

Glucose control (GC) with insulin decreases morbidity and mortality of critically ill patients. In this study we investigated GC performance over time during implementation of GC strategies within three intensive care units (ICUs) and in routine clinical practice.All adult critically ill patients who stayed for >24 h between 1999 and 2007 were included. Effects of implementing local GC guidelines and guideline revisions on effectiveness/efficiency-related indicators, safety-related indicators, and protocol-related indicators were measured.Data of 17,111 patient admissions were evaluated, with 714,141 available blood glucose levels (BGL) measurements. Mean BGL, time to reach target, hyperglycemia index, sampling frequency, percentage of hyperglycemia events, and in-range measurements statistically changed after introducing GC in all ICUs. The introduction of simple rules on GC had the largest effect. Subsequent changes in the protocol had a smaller effect than the introduction of the protocol itself. As soon as the protocol was introduced, in all ICUs the percentage of hypoglycemia events increased. Various revisions were implemented to reduce hypoglycemia events, but levels never returned to those from pre-implementation. More intensive implementation strategies including the use of a decision support system resulted in better control of the process.There are various strategies to achieve GC in routine clinical practice but with variable success. All of them were associated with an increase in hypoglycemia events, but GC was never stopped. Instead, these events have been accepted and managed. Statistical process control is a useful tool for monitoring phenomena over time and captures within-institution changes.
Abstract LB-2: TRIM28 is overexpressed in breast cancer and regulates the expression of multiple cancer-associated genes
Authors: Joseph Addison, Colton Koontz, Sarah McLaughlin, Ryan Livengood, Elena Pugacheva, Dongquan Chen, Chad Creighton, Alexey V. Ivanov
Journal: Cancer Research (2014)

Abstract The transcriptional regulator TRIM28 plays an important role in development, stem cells self-renewal, chromatin organization and DNA damage response. KAP1 is an essential co-repressor for KRAB zinc finger proteins (KRAB-ZNFs). Though KRAB-ZNFs represent the largest family of human transcription factors, their biological functions are largely unknown. We showed that KAP1 and certain KRAB-ZNFs were overexpressed in breast tumors and breast cancer cell lines at both mRNA and protein levels. More significantly, an active SUMOylated form of KAP1 was markedly increased in breast cancer cells. KAP1 depletion in several breast cancer cell lines slowed cell proliferation and inhibited primary tumor growth and metastasis of MDA-MB-231LN xenografts, while KAP1 overexpression conversely stimulated cell proliferation and tumor growth. KAP1 knockdown led to down-regulation of PTGS2/COX2, EREG, CD44, MMP1, MMP2 and ID transcription factors, previously implicated in cancer progression and metastasis. These results indicate that KAP1 and KRAB-ZNFs are up-regulated in breast cancer cells and contribute to increased cell proliferation, tumor growth and metastasis. Citation Format: Joseph Addison, Colton Koontz, Sarah McLaughlin, Ryan Livengood, Elena Pugacheva, Dongquan Chen, Chad Creighton, Alexey V. Ivanov. TRIM28 is overexpressed in breast cancer and regulates the expression of multiple cancer-associated genes. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-2. doi:10.1158/1538-7445.AM2014-LB-2
Hemoglobin synthesis in BFU‐E colonies derived from transfused blood in a sickle cell anemia patient
Authors: Kabita Bhaumik
Journal: American Journal of Hematology (1989)

Abstract In an in vitro progenitor cell culture system, a significant amount of normal hemoglobin (Hb A) synthesis was observed in a transfused sickle cell anemia (SS) patient, indicating the contribution of stem cells obtained from the normal donor's blood cells. As this study was done long after the last blood transfusion (&gt; 100 days), the survival of the donor's stem cells would indicate their repopulating the recipient's bone marrow. On extending the study to a few other transfused SS patients who had received multiple blood transfusions at frequent intervals, no such synthesis of Hb A was observed. A loss of repopulating ability of the donor's stem cells with frequent transfusions at short intervals is suggested as a possible explanation, with a gradual development of immune response against these cells as a second possibility. The differences in the survival of the donor's stem cells would thus appear to have some reflection on the frequency of blood transfusions required by an individual patient.
Efficacy of several plasma components in a young boy with chronic thrombocytopenia and hemolytic anemia who responds repeatedly to normal plasma infusions
Authors: Masayoshi Miura, Shoichi Koizumi, Katsuji Nakamura, Takashi Ohno, Tomoko Tachinami, Masahiko Yamagami, Noboru Taniguchi, Seiji Kinoshita, Charles F. Abildgaard
Journal: American Journal of Hematology (1984)

Abstract This report describes a patient with thrombocytopenia, microangiopathic hemolytic anemia, proteinuria, and microscopic hematuria that could be transiently improved by the infusion of plasma or various plasma components. An increase in platelet count following the transfusion of normal plasma was predictable and reproducible. In therapeutic trials with commercially available plasma components, factor VIII preparations were effective for inducing an increase in the platelet count and improving hemolytic anemia, but albumin, γ‐globulin, factor IX, and fibronectin preparations were ineffective. Serum from normal donors also relieved the symptoms of this condition in our patient. Partial plasma exchange (1,000 ml/m 2 of body surface area) was performed with albumin instead of normal plasma, but there was no significant effect on platelet count or anemia. Large, multimeric von Willebrand factor components of the factor VIII complex (VIII/vWF) were found in the patient's plasma when his platelet count was normal, but their levels were reduced when the platelet count was decreased. The multimers of the patient's plasma were larger than those in normal plasma, but smaller than those in normal platelet lysate. Although the patho‐genesis of this disease remains unknown, we conclude that transfusions of normal plasma, serum, or factor VIII concentrate provide a factor that causes significant improvement in the thrombocytopenia and hemolytic anemia. Furthermore, large VIII/vWF multimers are possibly directly involved in pathogenesis of this disease.
Mechanisms Leading to Sustained Reversion of β-Thalassemia in Mice by Doxycycline-Controlled Epo Delivery from Muscles
Authors: Selda Samakoglu, Delphine Bohl, Jean Michel Heard
Journal: Molecular Therapy (2002)

Erythropoiesis has been considered as a potential treatment for β-thalassemia. Although Epo secretion from genetically engineered muscles allowed long-term correction of the disease in the mouse, repeated injections of rHuEpo were disappointing in human patients. Whether different mechanisms operate in humans and mice or whether Epo exhibits different biological activity depending on the administration route is currently unknown. We provide evidence that mechanisms recruited over a 36-week follow-up in β-thalassemic mice were similar to those acting during stress-induced erythropoiesis in humans. β-Thalassemic mice were rendered steadily normocythemic by the intramuscular injection of a tetracycline-inducible AAV vector encoding mouse Epo. Doxycycline dosage was adapted to hematocrit. Circulating red blood cells essentially synthesized β-minor globin, the mouse equivalent to human γ-globin. Quantification of erythroid progenitors indicated a steady-state expansion of erythroid burst-forming units programmed for β-minor globin synthesis and a hastening of their maturation to hemoglobin-synthesizing cells. We discuss hypotheses that could account for the failure to recruit this mechanism over the long term in β-thalassemic patients and raise the possibility of Epo gene therapy trials to treat β-thalassemia.
Pectus Excavatum Causing a False???Positive Defect in the Liver
Authors: MOHAMMED IZHAR
Journal: Clinical Nuclear Medicine (1977)

A case of a localized area of absent activity in the left lobe of the liver is presented. On physical examination there was a marked pectus excavatum of the chest present. In view of the negative workup it is believed that the defect in the liver is due to pectus excavatum.
Clinical Trial of the Therapeutic Value of Certain Antirheumatic Drugs
Authors: P. Van Der Meer, S. A. Den Oudsten
Journal: Annals of the Rheumatic Diseases (1960)

The three drugs and the placebo were identified by the numbers I, II, III, IV, and they were handled under these designations throughout the experiment, the names not being disclosed even to the authors until the end of the trial.
PRE-INTERVENTIONAL LEFT VENTRICULAR 2D STRAIN PREDICTS THE RECOVERY OF MYOCARDIAL DYSFUNCTION AND IMPROVEMENT IN FUNCTIONAL CAPACITY AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION
Authors: Aleksander Kempny, Gerhard-Paul Diller, Stefan Orwat, Gerrit Kaleschke, Gregor Kerckhoff, Renate Schmidt, Julia Mascherbauer, Holger Reinecke, Helmut Baumgartner
Journal: Journal of the American College of Cardiology (2011)
THE HYSTEROID ASPECTS OF HYPNOSIS
Authors: AINSLIE MEARES
Journal: American Journal of Psychiatry (1956)

The hypnotized subject still retains some power to defend himself. The explanation of many of the hysteroid aspects of hypnotic behavior is found in terms of ego defense. The hypnotized subject tends to act in a way which he believes a hypnotized person does act. This tendency may be further elaborated into a purposeful hysteric defense.
Asthma symptoms: influence of personality versus clinical status
Authors: C. Put, M. Demedts, O Van Den Bergh, K. Demyttenaere, G. Verleden
Journal: European Respiratory Journal (1999)

The hypothesis that symptom-reporting in asthmatics does not necessarily correspond with clinical status, but is related to negative affectivity was investigated. One hundred and sixteen asthmatic patients filled out the Asthma Symptom Checklist (ASC), the Negative Emotionality Scale (NEM), and the McMaster-Asthma Quality-of-Life Questionnaire (AQLQ). The patients were grouped as either hospitalized, outpatient previously hospitalized or outpatient not previously hospitalized for asthma. Lung function data and Asthma Severity Scores (ASS) were also collected. The hospitalized group was retested after 3 months. The hospitalized group had lower AQLQ scores, higher ASS scores and worse lung function than both outpatient groups. However, the hospitalized group and the outpatients previously hospitalized group had higher ASC scores and NEM scores than the outpatients not previously hospitalized group. After discharge, when the hospitalized group had become clinically stable, their ASC and NEM scores remained comparable to those of the outpatient previously hospitalized group. Symptom-reporting in asthmatics is not necessarily in accordance with clinical status, but may be directly or indirectly mediated by personality, such as negative affectivity.
Abstract 4294: GE152: <i>In vivo</i> detection of tumor apoptosis as a tool for assessment of therapeutic efficacy
Authors: Duncan R. R. Hiscock, Graeme McRobbie, Rochelle E. Lear, Antonios Danikas, Chris Cawthorne, Kathryn Simpson, Maureen Zivanovic, Gavin Brown, Andrew Price, Kaye J. Williams, Caroline Dive
Journal: Cancer Research (2012)

Abstract A major challenge in personalized healthcare is predicting how effective a drug treatment is. This is particularly the case in oncology, where there is a call for better therapy monitoring to maximize drug treatment effectiveness leading to improved patient survival and help reduce healthcare costs. GE152, a nuclear imaging agent under development at GE Healthcare, is being evaluated preclinically as a tool to assess therapeutic efficacy by detecting tumor apoptosis. GE152 is based on a 99mTechnetium radiolabelled peptide that shows nanomolar affinity for a specific cell death target, as demonstrated by studies using Biacore technology. Biodistribution using the murine lymphoma (EL4) tumour therapy model has shown increased tumor uptake and retention of GE152 following chemotherapy, with positive tumor:muscle and tumor:blood ratios. Correlation of tumor apoptosis levels (determined by caspase activity) with GE152 tumor retention suggest a trend of increasing agent retention with rising levels of apoptosis (GE152 retention in low apoptotic tumors is 4.9%ID/g; GE152 retention in high apoptotic tumors is 8.2%ID/g).Further validation of GE152 was carried out using an apoptosis-specific inducible cell death model whereby HT29 colorectal cancer cell xenografts engineered to inducibly express either a constitutively active form of caspase-3 (which causes synchronous cell death in vivo when exposed to doxycycline) or an inactive point mutant. GE152 demonstrated greater uptake in tumors undergoing apoptosis (3.6% ID/g) than in controls (1.2% ID/g), correlating with caspase activity levels (and subsequent apoptosis) as determined both enzymatically and by IHC and blood-borne biomarkers of cell death. These results are in agreement with preliminary preclinical imaging studies using SPECT/CT, where region of interest analysis has demonstrated increased post-therapy tumor retention of GE152. We are currently optimizing the performance of GE152 by assessing different radiolabelling precursors to improve imaging agent pharmacokinetics. In addition to the current 99mTechnetium-based approach, we are exploring 18F radiolabelling options that would allow expansion of the agent's utility to PET imaging. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4294. doi:1538-7445.AM2012-4294
CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1–infected individuals
Authors: Sunil K Ahuja, Hemant Kulkarni, Gabriel Catano, Brian K Agan, Jose F Camargo, Weijing He, Robert J O'Connell, Vincent C Marconi, Judith Delmar, Joseph Eron, Robert A Clark, Simon Frost, Jeffrey Martin, Seema S Ahuja, Steven G Deeks, Susan Little, Douglas Richman, Frederick M Hecht, Matthew J Dolan
Journal: Nature Medicine (2008)
The Effect of Posture and of Compression of the Neck on Excretion of Electrolytes and Glomerular Filtration: Furthur Studies
Authors: W. N. VIAR, B. B. OLIVER, SEYMOUR EISENBERG, T. A. LOMBARDO, KATHRYN WILLIS, T. R. HARRISON
Journal: Circulation (1951)

Compression of the neck of the sitting subject caused increase in urinary sodium output without change in glomerular filtration (creatinine clearance) or apparent cardiac output (electrokymograph). The possible existence of an intracranial mechanism sensitive to alterations in volume of extracellular fluid and regulating the volume of extracellular fluid is suggested.
Myointimal Cells as a Possible Source of Replacement for Endothelial Cells in the Rabbit
Authors: CHUNG-HSIN TS'AO
Journal: Circulation Research (1968)

Regeneration of damaged endothelium has been studied by means of mechanical injury to rabbit abdominal aorta and inferior vena cava. Ultrastructural evidence suggests that myointimal cells can become endothelial cells. It is postulated that such a myogenic replacement of endothelial cells may occur under normal circumstances in the aorta. Injury to blood vessels merely accelerates this process.
SIXTEEN MONTHS' EXPERIENCE OF SALVARSAN
Authors: G. G. S. Stopford-Taylor, R. W. Mackenna
Journal: BMJ (1912)

WE have been using salvarsan since October, 1910, when Professor Ehrlich kindly placed some at our disposal for experimental purposes.From the first we have been much impressed by its effect on sypllilitic lesions, and we venture to present the following synopsis of our results.We have treated altogether 92 patients, almost all of whom were private patients.Eleven of thelm received two injections, and one patient three injections, making a total of 105 injections in all.Seventy-four of our patients received intravenous injections, and 18 were treated intramuscularly.Of the latter, 5 received an injection of the neutral emulsion, and in 13 the salvarsan was injected rubbed up in sterile olive oil.Of the 11 patients who had two injections, 8 had two intraviious injections, 1 had two intramuscular administrations, and 2 had an intramuscular and an intravenous injection.One of these had an intramuscuilar injection in neutral emulsion, followed ten months later by an intravenous dose; and the other had an intravenous injection, followed about eight weeks later by an intramiiuscular injection in oil.The patient to whom we administered three injections received them all intravenously.lThe Sex of the Patients a(le the Stage of the Disease.Eighty-three of our patients were male and 9 female; 41 were in the primary and secondary stages, 45 were in the tertiary stage; there were 2 cases of incipient general paralysis of the insane, 2 of locomotor ataxia, 1 of sclerosis of the cord following transverse myelitis, and 1 of congenital sypphilis.Dosage.As a rule we administered a full dose of 0.6 gram; 5 of our patients received 0.5, 4 received 0.45 gram, for the initial dose; one 0.4 gram, and 9 received an initial dose of 0.3 gram.Of those receiving two doses, 7 received 0.6 followed by 0.3, one received 0.45 followed by 0.3, three received 0.6 followed by 0.6 grami.The patient who received thlree injections had 0.3 gram on eacli occasion.
Increase of mastectomy rates after preoperative MRI in women with breast cancer is not influenced by patients age
Authors: Gianni Antonio Della Corte, Nicola Rocco, Vincenzo Sabatino, Corrado Rispoli, Albina Riccardi, Giuseppe Falco, Carmine Pezzulo, Federica Romano, Rita Compagna, Bruno Amato, Antonello Accurso
Journal: International Journal of Surgery (2014)
Complementary Health Practices
Authors: Josephine P. Briggs, Jack Killen
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal