tbuckley/cabot-search huggingface dataset:
Recent advances of Ultrastructural immunocytochemistry of epidermal Langerhans cells
Authors: D. SCHMITT, C. DEZUTTER-DAMBUYANT, M. FAURE, J. THIVOLET
Journal: British Journal of Dermatology (1985)

Using electron microscopy, the immunological visualization of the membrane antigens of Langerhans cells (LC) can be performed by immunoperoxidase and immunogold techniques. The immunoperoxidase labelling permits the identification of only one antigen and the observation of qualitative variations of surface antigens. The immunogold method allows the identification of one antigen or simultaneously two or three surface antigens using gold particles of various sizes. This technique can be used to quantify the surface density of antigens on the cell membrane. The simultaneous identification of different surface antigens can be correlated with the ultrastructural characteristics of the cells. Using this technique we have recently demonstrated the existence of LC subsets in normal epidermis, and the presence of circulating T6-positive cells in normal subjects. In addition, a very low density of T4 antigenic sites on the LC membrane surface was observed. Several problems of a double-labelling immunogold technique related to steric hindrance and current artifacts are discussed.
Humoral Immune Response to Some Benzylpenicillin Preparations
Authors: P. DE HAAN, G. L. KALSBEEK
Journal: Allergy (1983)

In this study the humoral immune responses to long-term administration of benzylpenicillin preparations with and without adjuvants were compared. In 44.4% of the patients on long-term treatment with a benzylpenicillin preparation containing oil and alum monostearate, an induction of benzylpenicilloyl (BPO)-specific IgG, IgM and IgE was demonstrated during and after the course. Patients treated with a benzylpenicillin preparation containing no oil and alum monostearate showed only a very weak BPO-specific IgM and IgG response during the course. In patients in whom long-term treatment with a benzylpenicillin preparation without adjuvants was initiated by a benzylpenicillin preparation containing oil and alum monostearate, not only BPO-specific IgM and/or IgG but also IgE were demonstrated in 13.0%. The differences in immune response in the various long-term courses were significant (P less than 0.05). The data suggest that the presence of such adjuvants as oil and alum monostearate has an influence on the synthesis of BPO-specific antibodies. However, it can not be excluded that the difference in immunogenicity had some unknown connection with the differences in penicillin/blood levels.
Der p 2 Stimulate Inflammatory Responses from Lung Epithelial cells and Macrophages through the TLR2 and MAPK pathway
Authors: S. Tanyaratsrisakul, O. Jirapongsananuruk, W.R. Thomas, S. Piboonpocanun, D.R. Voelker
Journal: Journal of Allergy and Clinical Immunology (2012)
Peptic Ulcer: New Therapies, New Diseases
Authors: MORTON I. GROSSMAN
Journal: Annals of Internal Medicine (1981)

Although hospitalizations and deaths attributable to peptic ulcer have decreased notably during the past decade, it is not certain whether this decrease is because of reduced incidence of new cases or changes in other factors, such as the severity of the disease. Several genetic traits associated with peptic ulcer have been recognized. Hyperpepsinogenemia I is the most prevalent. Peptic ulcer is a heterogeneous group of disorders with multiple genetic and environmental causes. One manifestation of the diversity of ulcer disease is the variety of physiologic abnormalities seen in patients. The use of endoscopy has enabled more reliable evaluation of new treatments. Histamine H2-receptor antagonists are the dominant mode of treatment, but increasing attention is being given to agents that enhance the resistance of the mucosa to injury, such as prostaglandins. Because of the lower frequency of side effects, proximal gastric vagotomy is gradually replacing truncal vagotomy with drainage. The possibility that endoscopic treatments, such as laser coagulation, may reduce mortality from bleeding ulcers is being investigated.
National Preparedness for a Catastrophic Emergency
Authors: Lawrence O. Gostin, Dan Hanfling
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elevated Serum Levels of Mucin-associated Antigen in Patients with Acute Respiratory Distress Syndrome
Authors: JIN-YUAN SHIH, SHUENN-CHEN YANG, CHONG-JEN YU, HEUY-DONG WU, YUANG-SHUANG LIAW, REEN WU, PAN-CHYR YANG
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Increased serum levels of mucin-associated antigen have been previously demonstrated in patients with cystic fibrosis (CF) and interstitial pneumonia, and in lung-transplant recipients. The present study assessed the serum airway mucin levels in patients with acute respiratory distress syndrome (ARDS). An enzyme-linked immunosorbent assay (ELlSA) method with a human-airway-mucin-specific monoclonal antibody (17Q2) was used to measure serum mucin levels in normal subjects, chronic smokers, patients with chronic bronchitis and other pulmonary diseases, patients with acute cardiogenic lung edema, and patients with ARDS. The serum mucin levels measured 9.9 ± 0.8 ng/ml (mean ± SEM, n = 59) in normal subjects, 12.7 ± 1.6 ng/ml (n = 29) in chronic smokers, 21.8 ± 1.9 ng/ml (n = 28) in patients with chronic bronchitis and other pulmonary diseases, 9.0 ± 3.1 ng/ml (n = 5) in patients with acute cardiogenic lung edema. The serum mucin level was 53.8 ± 6.6 ng/ml (n = 13) in patients with ARDS (p < 0.05, as compared with the four other groups). Serial measurements of serum mucin levels were obtained in patients with ARDS. Statistical analysis showed an inverse correlation of serial measurements of serum mucin with static respiratory-system compliance (p = 0.021), an inverse correlation of sequential serum mucin levels and log(PaO2 /Fi O2 ) (p = 0.016), and a positive correlation of sequential serum mucin levels and lung injury score (LIS) (p = 0.019). Gel-filtration analysis showed that mucin-associated antigens in ARDS sera were polydispersed and smaller than the antigens in normal sera. This study indicates that an increasing amount of degraded mucin occurs in patients with ARDS.
Leicestershire: encouraging specialisation in a general practice.
Authors: R J Thew
Journal: BMJ (1982)

'WNilli... BT, Dixo RA, K-oweld-n J. BM dp23:638-46. 'Willi... BT, Kn-wld-n j Ge eA-l p ... tifi-nr dpi,.ppl:JI9-12. 'Di... RA, W'iliiiBT. T-1-v -onh, of dep.,msig: 100 000 p*fi ith eights i 8r /A d7 197J,;i:560-3. Fry1. Th,, -ss agai.. deputising tervU.pd-t 1974 9; 1548-52. W * h Y u f mily dot. Londo: C1974n 4-11. A' . Aoymou,. Out of h.-r wok. 7 R Coll G-?r P-,c 1970 jtl:3-4. 'Crowe MGF, Hurood DS, Taylor RW.t Out of h.-r .IIls in . Leiom shire pretice. Br Med 7 1970p i:1582-4 . Murr-y TS, B-rbJH. W-ok lo d of * domr iadputisig .-i -7 R CUGll GPr, 1977;27:209-11.  tvno SK. Appointment sy-.e i g-rl p-ri-eie D. patimu like them -d h.. do the~y sff-e v-or-bd. Br Med,7 1966jii:5158 S-vnJSK. Appoinm t sy.in genr pr1ie. H.-. -e fi Br Md R7 1967; i:827-9.  Hati DWit. The oR duty *r gmnsof g-nrl ret1onr in CI Europemeutis7 R ColIl tG' P-,v 1976j211:19-34. Deputisiny -eric-s ne eod of pr etiee. Br Md 7 1978;ji:998.
THE ABILITY OF GROUP A STREPTOCOCCI KILLED BY HEAT OR MERCURY ARC IRRADIATION TO RESIST INGESTION BY PHAGOCYTES
Authors: Grove G. Wiley, Armine T. Wilson
Journal: The Journal of Experimental Medicine (1956)

Living group A streptococci which resist ingestion by human neutrophils in an in vitro test still do so after they have been killed by exposure to heat or to mercury are irradiation.
Running the Hospitals
Authors: John Lister
Journal: New England Journal of Medicine (1968)

THE horizon of the young man aspiring to a career as a surgeon or a physician in hospital practice is usually bounded by thoughts of examinations and the hopes that the patronage of his chief will eventually obtain for him a staff appointment. His clinical enthusiasm is at its height, and his mind abounds with ideas for research projects and scientific papers and communications to learned societies. His anxieties apart from those concerning his future career are usually the ones common to any young man and chiefly concern the financial problem of supporting himself and most probably a wife and . . .
Aggregate Risk of Cardiovascular Disease Among Adolescents Perinatally Infected With the Human Immunodeficiency Virus
Authors: Kunjal Patel, Jiajia Wang, Denise L. Jacobson, Steven E. Lipshultz, David C. Landy, Mitchell E. Geffner, Linda A. DiMeglio, George R. Seage, Paige L. Williams, Russell B. Van Dyke, George K. Siberry, William T. Shearer, Luciana Young, Gwendolyn B. Scott, James D. Wilkinson, Stacy D. Fisher, Thomas J. Starc, Tracie L. Miller
Journal: Circulation (2013)

Perinatally HIV-infected adolescents may be susceptible to aggregate atherosclerotic cardiovascular disease risk, as measured by the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) coronary arteries and abdominal aorta risk scores, as a result of prolonged exposure to HIV and antiretroviral therapy.Coronary arteries and abdominal aorta PDAY scores were calculated for 165 perinatally HIV-infected adolescents, using a weighted combination of modifiable risk factors: dyslipidemia, cigarette smoking, hypertension, obesity, and hyperglycemia. Demographic and HIV-specific predictors of scores ≥1 were identified, and trends in scores over time were assessed. Forty-eight percent and 24% of the perinatally HIV-infected adolescents had coronary arteries and abdominal aorta scores ≥1, representing increased cardiovascular disease risk factor burden. Significant predictors of coronary arteries scores ≥1 included male sex, history of an AIDS-defining condition, longer duration of use of a ritonavir-boosted protease inhibitor, and no prior use of tenofovir. Significant predictors of abdominal aorta scores ≥1 included suppressed viral load, history of an AIDS-defining condition, and longer duration of boosted protease inhibitor use. No significant changes in coronary arteries and abdominal aorta risk scores were observed over the 4-year study period.A substantial proportion of perinatally HIV-infected youth have high PDAY scores, reflecting increased aggregate atherosclerotic cardiovascular disease risk factor burden. High scores were predicted by HIV disease severity and boosted protease inhibitor use. PDAY scores may be useful in identifying high-risk youth who may benefit from early lifestyle or clinical interventions.
Accuracy of auscultatory blood pressure measurement with a long cuff.
Authors: G A van Montfrans, G M van der Hoeven, J M Karemaker, W Wieling, A J Dunning
Journal: BMJ (1987)

Intra-arterial blood pressure was compared with simultaneous auscultatory measurements in 37 subjects with a wide range of blood pressures and arm circumferences; six cuffs of various lengths and widths were used. Nineteen subjects had an arm circumference of 34 cm or more (mean 40 cm) and the other 18 were considered to be non-obese and had a mean arm circumference of 30 cm. With each larger cuff, in terms of bladder surface area, auscultatory blood pressure decreased a few mm relative to intra-arterial pressure both for systolic and for diastolic measurements. Apart from diastolic pressure measured with the two 12 cm wide cuffs (12 X 23 cm, 12 X 30 cm) in the obese group all other auscultatory measurements differed less than 5% from intra-arterial pressure, albeit with considerable variability among the subjects. The differences in error among measurements with the four largest cuffs in the obese group (13 X 30 cm, 14 X 30 cm, 14 X 38 cm, and a conical cuff) were clinically irrelevant, and there was even less to choose among all six cuffs in the non-obese subjects. These results suggest that auscultatory blood pressure may be measured with acceptable accuracy with a single long bladdered cuff both in subjects with large arms and in subjects with normal sized arms.
Reductions in Funding for Medical Research
Authors: Lem Moyé
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical Implications for Patients With Long QT Syndrome Who Experience a Cardiac Event During Infancy
Authors: Carla Spazzolini, Jamie Mullally, Arthur J. Moss, Peter J. Schwartz, Scott McNitt, Gregory Ouellet, Thomas Fugate, Ilan Goldenberg, Christian Jons, Wojciech Zareba, Jennifer L. Robinson, Michael J. Ackerman, Jesaia Benhorin, Lia Crotti, Elizabeth S. Kaufman, Emanuela H. Locati, Ming Qi, Carlo Napolitano, Silvia G. Priori, Jeffrey A. Towbin, G. Michael Vincent
Journal: Journal of the American College of Cardiology (2009)
ANTIRACHITIC PROPERTIES DEVELOPED IN HUMAN MILK BY IRRADIATING THE MOTHER
Authors: ALFRED F. HESS
Journal: JAMA (1927)

It has been firmly established that exposure to ultraviolet radiations, whether through the rays of the sun or artificial sources, regularly affords protection from rickets to animals and to human beings. The question arises whether similar protection can be transmitted through the milk by the mother to the young. It is an aspect that has both theoretical and practical significance. The subject of ultraviolet ray therapy is so recent that little investigative work has been carried out on ancillary aspects, and none whatever in regard to the reaction of the nursing woman to irradiation. Luce,<sup>1</sup>who conducted a series of similar experiments with cow's milk, concluded that "the antirachitic value depends on the diet of the cow and possibly also on the degree of illumination to which she is exposed." The potency developed by the milk was not great. More recently Steenbock, Hart and their associates<sup>2</sup>tested the
Fetal hydrocephalus. II. Amelioration of fetal porencephaly by in utero therapy in nonhuman primates
Authors: M. Michejda
Journal: JAMA (1984)

The postnatal course of a form of infantile porencephaly under pressure in monkeys was evaluated by comparing brain development between animals that had received the hydrocephalic antenatal vent for intrauterine treatment and those that had not been treated antenatally. Brain development was assessed by computed tomographic scans. The studies showed asymmetric malformations and associated porencephalic lesions in infant monkeys not treated in utero, despite installation of a conventional postnatal ventriculoperitoneal shunt. In contrast, apparently normal development of brain tissue in infants given intrauterine therapy was observed.
Quantifying a Nonnotifiable Disease in the United States
Authors: D. Kevin Horton, Paul Mehta, Vinicius C. Antao
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prescription Drug Monitoring Programs—Reply
Authors: Hallam M. Gugelmann
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Circulating Levels of Interleukin-18 Independent of Body Fat and Fat-Free Mass
Authors: Christian Herder, Jens Baumert, Hubert Kolb, Wolfgang Koenig, Stephan Martin, Barbara Thorand
Journal: Diabetes Care (2006)

Elevated systemic concentrations of interleukin (IL)-18, a potent proinflammatory cytokine, have recently been reported to increase the risk of developing type 2 diabetes in a prospective case-cohort study with a mean follow up of 10.8 years (1). IL-18 is secreted from adipocytes (2), and IL-18 levels were found to be increased in obesity and decreased after weight loss in obese women (3). However, we did not observe a direct relationship between BMI and IL-18 levels in a large population-based sample (1). Another recent study in 144 men surprisingly reported a significant association of IL-18 with fat-free mass (4). We …
Potential Molecular Basis of Different Physiological Properties of the Transient Outward K <sup>+</sup> Current in Rabbit and Human Atrial Myocytes
Authors: Zhiguo Wang, Jianlin Feng, Hong Shi, Amber Pond, Jeanne M. Nerbonne, Stanley Nattel
Journal: Circulation Research (1999)

Abstract —The properties of the transient outward current ( I to ) differ between rabbit and human atrial myocytes. In particular, rabbit I to is known to recover more slowly than its human counterpart and to show much more frequency dependence. To assess the possibility that these physiological differences may reflect differing expression of K + channel subunit gene products, we used a combination of whole-cell voltage-clamp, heterologous expression, pharmacological, antisense, and Western blot techniques. The inactivation of I to in rabbit atrial myocytes was significantly slowed by hydrogen peroxide, with human I to being unaffected. Use-dependent unblocking with 4-aminopyridine was not seen for rabbit I to nor for Kv1.4 currents in Xenopus oocytes, whereas human I to showed strong use-dependent unblock (as did Kv4 currents). Western blots indicated the presence of Kv4 proteins in both human and rabbit atrial membranes, but Kv1.4 was only detected in the rabbit. Antisense oligodeoxynucleotides directed against Kv4.3, Kv4.2, or Kv1.4 subunit sequences significantly inhibited I to current density in cultured rabbit atrial myocytes, whereas only Kv4.3 antisense significantly inhibited I to in human cells. Neither mismatch oligodeoxynucleotides nor vehicle altered currents in either species. We conclude that, unlike human atrial myocytes, rabbit atrial myocytes express Kv1.4 channel subunits, which likely contribute to a number of important physiological differences in I to properties between the species. To our knowledge, these studies constitute the first demonstration of a functional role for Kv1.4 channels in cardiac membranes and provide insights into the molecular mechanisms of an important cardiac repolarizing current.
GMC must consider case against paediatricians who suspected parents of fabricating child's illness
Authors: Clare Dyer
Journal: BMJ (2006)

A couple suspected of fabricating their daughter's illness and threatened with having her taken into care have won a High Court ruling that the General Medical Council must reconsider their complaint against the two paediatricians who raised the concerns.

The girl, now 15 years old, was eventually diagnosed with chronic fatigue syndrome. The local council agreed to withdraw the care proceedings and was ordered to pay the …
Pre-B Lymphocyte Protein 3 (VPREB3) Expression in the Adrenal Cortex: Precedent for non-Immunological Roles in Normal and Neoplastic Human Tissues
Authors: Saulo J. A. Felizola, Koshin Katsu, Kazue Ise, Yasuhiro Nakamura, Yoichi Arai, Fumitoshi Satoh, Hironobu Sasano
Journal: Endocrine Pathology (2015)