tbuckley/cabot-search huggingface dataset:
EFFECTS OF THE ADENOSINE A1-ANTAGONIST ROLOFYLLINE ON RENAL FUNCTION IN ACUTE HEART FAILURE PATIENTS: RESULTS FROM THE PROTECT STUDY
Authors: Adriaan A. Voors, Howard C. Dittrich, Barry M. Massie, Paul DeLucca, George Mansoor, Michael M. Givertz, None PROTECT Investigators and Committees
Journal: Journal of the American College of Cardiology (2010)
Metatarsal periosteal reactions: a common non-specific finding in radiographs of the diabetic foot.
Authors: C. E. Williams, B. M. Carey, A. J. Birtwell, J. K. Wales, P. G. Wiles
Journal: BMJ (1988)

dehydrated (five had had gastric surgery, one was taking H2 receptor blockers) while the others generally had a milder illness and were often recovering by the time the results of blood cultures were available.
Nutritional Management of Pregnancy Complicated by Diabetes: Historical Perspective
Authors: Denise Ney, Dorothy R Hollingsworth
Journal: Diabetes Care (1981)

The important role of diet in the management of pregnancies complicated by diabetes has been recognized since the nineteenth century. In this historical review we have traced the evolution of the diabetic diet from the pre-insulin era, when diabetic pregnancies were not only rare, but accompanied by high maternal mortality and fetal loss to 1981, when the nutritional management of carbohydrate intolerance during gestation is again raising provocative questions. Our recent understanding of diabetes as a heterogeneous syndrome, the 1979 dietary guidelines of the American Diabetes Association (ADA), and the 1980 revised Recommended Dietary Allowances (RDA) for pregnant and lactating women are summarized as representative of the current approach to the nutritional management of diabetic pregnancies. Many questions remain unanswered. These include the hundred-year-old debate concerning the optimal amount of carbohydrate in the diabetic diet, the possible beneficial role of large amounts of dietary fiber, and the nagging concern about total caloric intake in type I insulin-dependent diabetes mellitus (IDDM) versus type II non-insulin-dependent diabetes mellitus (NIDDM) pregnant diabetic women. We suggest that nutritional counseling during gestation in the future may need to be more highly individualized as metabolic distinctions between different types of patients with carbohydrate intolerance are more clearly delineated.
Long-term follow-up of complete Barrett’s eradication endoscopic mucosal resection (CBE-EMR) for the treatment of high grade dysplasia and intramucosal carcinoma
Authors: A. Larghi, C. Lightdale, A. Ross, P. Fedi, J. Hart, H. Rotterdam, A. Noffsinger, L. Memeo, G. Bhagat, I. Waxman
Journal: Endoscopy (2007)

In patients with Barrett's esophagus (BE), targeted endoscopic mucosal resection (EMR) of visible lesions of high grade dysplasia (HGD) or intramucosal adenocarcinoma (IMC) is effective, but carries the risk of leaving in place synchronous lesions and Barrett's epithelium with the potential for recurrent disease. We evaluated the safety and long-term efficacy of complete Barrett's eradication EMR (CBE-EMR) for the treatment of patients with HGD or IMC, independently of the presence of macroscopically visible lesions or surgical risk.26 consecutive patients with BE and HGD or IMC underwent CBE-EMRs, which were performed with the endoscopic cap suction method and/or a 2.3-mm monofilament mucosectomy snare. Endoscopic follow up after completion of resection was carried out to assess the rate of residual or recurrent BE with or without HGD or IMC.24 patients completed the study. They underwent a total of 44 EMR sessions with a median of 3 pieces (range 1-8) removed per session. Two patients with immediate bleeding were successfully managed endoscopically. Three patients developed an early esophageal stricture that was completely resolved with a single endoscopic dilation. After a median follow-up of 28 months (range 15-51 months), persistent endoscopic and histologic eradication of BE was demonstrated in 21 patients (87.5 %). In two patients, Barrett's epithelium was detected beneath the neosquamous epithelium 3 months after completion of the resection. In the remaining patient, IMC was found in a nodule seen and removed by EMR at 12-month surveillance endoscopy.CBE-EMR is a safe and highly effective long-term treatment that should be offered to all patients with Barrett's esophagus with HGD and IMC.
Segregation at three loci explains familial and population risk in Hirschsprung disease
Authors: Stacey Bolk Gabriel, Rémi Salomon, Anna Pelet, Misha Angrist, Jeanne Amiel, Myriam Fornage, Tania Attié-Bitach, Jane M. Olson, Robert Hofstra, Charles Buys, Julie Steffann, Arnold Munnich, Stanislas Lyonnet, Aravinda Chakravarti
Journal: Nature Genetics (2002)
Regulating Firearm Advertisements
Authors: Paul H. Blackman
Journal: JAMA (1997)

<h3>To the Editor.</h3> —Britain's new handgun ban, accompanied by curtailment of magazines about guns and knives, and the call by Johns Hopkins researchers<sup>1</sup>for curbs on the contents of advertisements, the accuracy of which can readily be defended, should remind Americans of the indivisibility of fundamental freedoms. The advertisements in question seek to persuade women in the market for a handgun for protection that they should choose 1 brand or model over others, based on size, quality, and cost. Only 1 of the 8 advertisements even appeared in a nongun publication, although the others might if US magazines had greater concern with providing the marketplace of ideas Justice Holmes thought the First Amendment envisioned. The idea the advertisements are suggesting is that handguns may add to the security of middle-class women aged 21 to 45 years, whom the survey by Kleck and Gertz<sup>2</sup>indicated use handguns for protection well more
PWE-048 Gastric volume response and emptying after a large liquid nutrient meal in functional dyspepsia and health assessed by non-invasive gastric scintigraphy (GS) and MRI: a pilot study to identify candidate biomarkers
Authors: E Tucker, H Parker, C Hoad, N Hudders, A Perkins, P E Blackshaw, L Marciani, C Costigan, P Gowland, M Fox
Journal: Gut (2012)

<h3>Introduction</h3> Dyspeptic symptoms are common but investigations rarely explain them. This lack of information may be because: (1) Current test meals are small (∼200 ml) and don9t trigger symptoms (2) gastric emptying half time (T50) and/or retention at 2 or 4 h may not elicit underlying pathophysiology. By contrast, MRI studies suggest that gastric volume change after a meal may identify impaired accommodation in functional dyspepsia (FDs). <h3>Aim</h3> GS and MRI with a 400 ml liquid test meal were applied to identify candidate biomarkers that distinguish FDs from healthy volunteers (HVs). <h3>Methods</h3> FDs with postprandial distress by Rome III criteria and normal endoscopy or 24 h pH-studies were recruited. Results were compared to age and sex matched HVs. Sensation at 400 ml and Maximum Tolerated Volume (MTV) was assessed by nutrient drink test (0.75 kcal/ml@40 ml/min). Participants were then randomised to GS and MRI with 400 ml liquid test meal (0.75 kcal/ml@40 ml/min) on two separate days. Directly comparable measurements of gastric content volume were analysed: Gastric contents volume after meal ingestion (GCV0), GE half-time [T50], and GErate@T50 [ml/min]. <h3>Results</h3> FDs (n=8; 7 female) were each compared to those of three matched HVs (n=24). HVs weighed more than FDs (p&lt;0.018) fullness at 400ml was similar (p=0.21) but dyspeptic sensations were lower (bloating, nausea, pain, p&lt;0.01) and MTV was greater (median 960 (IQR 750–1330) vs 480 (±400–760) ml, p=0.015). With GS, HVs had higher GCV0 than FDs (345 (333–358) vs 325 (310–350) ml; p=0.052), T50 (48 (39–56) vs 52 (44–54) min; p=0.710) was similar but GErate@T50 was faster (3.5 (3.0–4.2) ml/min vs 2.7 (2.1–3.1) ml/min; p=0.012). With MRI, compared to GS, measurements of GCV and T50 were larger (p&lt;0.001), and GErate was slower (p=0.012); but no significant differences between groups. <h3>Conclusion</h3> FD patients are characterised by abnormal gastric sensorimotor response to a large, liquid nutrient meal. Rapid early emptying (reduced GCV0) is followed by slow late emptying (slow GErate@T50). These GS measurements, with dyspeptic symptoms at 400 ml, are biomarkers in FD. MRI measurements of GCV, residual volume, meal and secretions do not provide the same clarity. These findings are consistent with the hypothesis that impaired accommodation in gastric filling in FD leads to rapid nutrient delivery to small bowel triggering powerful neuro-hormonal feedback that slows subsequent emptying. <h3>Competing interests</h3> None declared.
Cancer Patients’ Perception of the Quality of Communication Before and After the Implementation of a Communication Strategy in a Regional Cancer Center in India
Authors: Sukdev Nayak, Jeeta Parija B. Pradhan, Suresh Reddy, J. Lynn Palmer, Tao Zhang, Eduardo Bruera
Journal: Journal of Clinical Oncology (2005)

Purpose Physician communication is one of the areas that cancer patients have expressed their lowest level of satisfaction. Very few studies have used patient-based outcomes in the Developing world. Methods We conducted a survey of 400 consecutive patients attending our outpatient clinic (Step I). Survey results were used to make changes in the physical layout of the setting to increase privacy and to educate staff regarding practical techniques on communication (Step II). A second group of 400 patients were interviewed immediately after the implementation of the new communication strategy (Step III). Results Comparing Step I (n = 400) and Step III (n = 400) we observed a favorable response (“yes” v “no”) with regard to overall satisfaction with communication in 52 patients (13%) versus 132 patients (33%; P = .0001), privacy in 21 patients (5%) versus 279 patients (70%; P = &lt; .001), no interruptions in 170 patients (42%) versus 330 patients (82%; P = &lt; .001), clear language in 57 patients (14%) versus 227 patients (57%; P = &lt; .001), sufficient time in 88 patients (22%) versus 168 patients (42%; P = &lt; .001), doubts cleared by the doctor in 105 patients (26%) versus 225 patients (56%; P = &lt; .001). Patients older than 65 years and manual laborers were significantly more satisfied compared with younger patients and those patients with nonmanual occupations, during both Steps I and III. Conclusion We conclude that cancer patients in Developing countries have many unmet needs regarding communication and that simple changes in the organization of clinics and oncologist education can result in major improvements in satisfaction with the quality of communication.
Cognitive-behavioral therapy versus other therapies: Redux
Authors: Timothy P. Baardseth, Simon B. Goldberg, Brian T. Pace, Andrew P. Wislocki, Nick D. Frost, Jamila R. Siddiqui, Abigail M. Lindemann, D. Martin Kivlighan, Kevin M. Laska, Aaron C. Del Re, Takuya Minami, Bruce E. Wampold
Journal: Clinical Psychology Review (2013)
Feeling cold after donepezil
Authors: S. Thiyagesh, C. Young, S. Spence
Journal: Journal of the Royal Society of Medicine (2004)

We have seen four patients who reported feeling cold within a few weeks of starting donepezil hydrochloride for Alzheimer's disease. On investigation, their temperatures and peripheral circulations were within normal limits. Their Mini Mental State Examination scores at the start of treatment ranged from 13/30 to 22/30 and the medical histories included (1) epilepsy; (2) hypertension, poly-myalgia rheumatica, osteoporosis; (3) transient ischaemic attack, varicose veins, pneumoconiosis; (4) sigmoid diverticular disease, respectively. None had previously reported disturbed temperature perception. Because of this symptom, which began within 8 weeks of starting donepezil, the patients kept their rooms very warm; one patient set the thermostat to 24 °C. Discontinuation of the medication alleviated symptoms in two patients; one died from unrelated causes; and the other decided to tolerate the symptom in view of the benefits derived from donepezil.

A search of Psyclit, Embase, Medline, CINAHL and ACP Journal Club yielded no reports of such a side-effect from donepezil or other cholinergic agents. Nor was it seen in acute pyridostigmine poisoning.1 In healthy volunteers eptastigmine, a new acetylcholinesterase inhibitor, may have a weak effect on (lowering) body temperature.2

Although Alzheimer's disease may involve the suprachiasmatic nucleus of the hypothalamus, and thus potentially affect circadian and bodily temperature rhythms,3 there are no previous reports of changes in self-awareness of temperature in this condition. Temperature disturbances of this sort, although not life-threatening, can be uncomfortable and also costly in extra heating. The possible drug causation deserves systematic assessment. Meanwhile, carers should be particularly sympathetic to patients with Alzheimer's disease when they complain of feeling cold.
Finding Our Way—Perspectives on Care at the Close of Life
Authors: Stephen J. McPhee
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
STUDIES ON YELLOW FEVER IN SOUTH AMERICA
Authors: Nelson C. Davis, Raymond C. Shannon
Journal: The Journal of Experimental Medicine (1929)

1. Batches of Aëdes (Stegomyia) aegypti which had fed on monkeys in the early febrile stage of yellow fever and which has subsequently passed the usually accepted extrinsic incubation period for the virus, failed to transmit the disease to normal monkeys in approximately fifty per cent of the experiments. During the same time over eighty per cent of blood transfers were successful. 2. The monkeys which failed to show fever following mosquito bites later proved resistant to the inoculation of blood or tissues containing virus. 3. The incubation, or afebrile, period in monkeys following the bites of infected mosquitoes varied from less than twenty-four hours to fifteen days. It averaged somewhat longer in non-fatal than in fatal infections.
Walk in peace: banish landmines from our globe
Authors: E. O'Brien
Journal: BMJ (1997)

Gerhard Rose, one of Germany's most respected physicians, stood in the prisoner's dock at the Palace of Justice in Nuremberg, Germany, awaiting his sentence for "murders, tortures, and other atrocities committed in the name of medical science."Dr Rose, the department head for tropical medicine of the Robert Koch Institute, was on trial along with 22 of his medical colleagues, for perpetrating "ghastly" and "hideous" experiments on concentration camp prisoners during the war. 1 At one point in the trial when the chief prosecution witness, Dr Andrew C Ivy of the medical school of the University of Illinois, underscored the basic principle "that human experimental subjects must be volunteers," Dr Rose and his defence counsel vigorously objected, arguing that the United States was guilty of similar medical practices and giving several examples to support this contention.
ANEURISMAL TUMOR OF THE RIGHT ALVEOLAR PROCESS AND VAULT OF THE MOUTH TREATED BY INJECTION.
Authors: JOHN S. MARSHALL
Journal: JAMA (1891)

Mr. C. B. H., of Chicago, American, aged 26 years, occupation traveling salesman, was referred to me December 26, 1888, for counsel and treatment by Dr. M. Stout, of Chicago, with the following history: Some eighteen or twenty months previous to this examination the gentleman had submitted to the extraction of all his superior teeth, except the central incisors. The operation was performed under nitrous-oxide gas; the mouth was badly bruised and lacerated on account of the difficulty in extracting the teeth. A few weeks afterwards he noticed a swelling upon the inner side of the right alveolar ridge, which continued to enlarge as the months went by, and prevented the making of the artificial denture, which he was anxious to have placed in his mouth. There was no pain or uncomfortable feeling about the tumor, except when engaged in vigorous exercise; at such times pulsation in the part would
Role of Growth Hormone in Diabetes Mellitus
Authors: John E. Gerich
Journal: New England Journal of Medicine (1984)

Numerous studies of both laboratory animals and human beings have implicated poor glycemic control as a risk factor for development of the so-called long-term complications of diabetes mellitus (neuropathy, nephropathy, retinopathy, and premature atherosclerosis).1 , 2 The uncertainty that still exists derives primarily from two factors: the lack of an unequivocal demonstration that good glycemic control can diminish the severity or frequency of long-term complications in human beings3 (currently being addressed by the Diabetes Control and Complications Trial, a prospective randomized study sponsored by the National Institutes of Health), and the lack of knowledge concerning the mechanism or mechanisms by which poor . . .
CEREBRAL SYPHILIS, WITH REPORT OF CASES.
Authors: WILLIAM HESSERT
Journal: JAMA (1896)

I need offer no apology for the introduction of a subject such as this, as it is well deserving of our attention by virtue of its high degree of importance in diagnosis and treatment. The frequency of syphilis of the nervous system is becoming more and more appreciated, thus securing for it an earlier recognition and the establishment of a more definite train of clinical phenomena than formerly. Gray, writing only four years ago, would make no more than a tentative diagnosis of cerebral syphilis, unless there were present, 1, undoubted specific infection; 2, convulsions or hemiplegia, or 3, marked success of specific treatment. Gowers, in his great work, allots to nervous syphilis no special chapter, referring to it among causative agents in the production of endarteritis, cerebral softening, hemorrhage, insanity, etc. I need not dwell upon the widespread prevalence of syphilis, which is one of the most important diseases
Na+/Ca2+ exchange-mediated calcium entry in human lymphocytes.
Authors: M Balasubramanyam, C Rohowsky-Kochan, J P Reeves, J P Gardner
Journal: Journal of Clinical Investigation (1994)

Regulation of cytosolic Ca2+ and cytosolic Na+ is critical for lymphocyte cation homeostasis and function. To examine the influence of cytosolic Na+ on Ca2+ regulation in human peripheral blood lymphocytes, Ca2+ entry and cytosolic Ca2+ (measured with fura-2) were monitored in cells in which cytosolic Na+ was increased and/or the Na+ gradient was decreased by reduction of external Na+ concentration. Ouabain-treated cells (0.1 mM for 30 min at 37 degrees C), suspended in Na(+)-free medium, showed a 30-65% increase in Ca2+ uptake compared to cells in 140 mM Na+ medium. Enhanced Ca2+ influx was entirely dependent on ouabain pretreatment and reversal of the Na+ gradient. Na pump inhibition or Na ionophore addition and subsequent exposure to Na(+)-free medium resulted in a sustained elevation of cytosolic Ca2+. As preincubation of cells in Ca(2+)-free medium further enhanced the ouabain-dependent increase in cytosolic Ca2+, the effects of the microsomal Ca(2+)-ATPase inhibitor thapsigargin on Ca2+ influx and cytosolic Ca2+ were studied. Thapsigargin stimulated Ca2+ entry following ouabain pretreatment and reversal of the Na+ gradient; the effects of thapsigargin were retained in the presence of LaCl3, a potent inhibitor of store-dependent calcium influx pathways. These results show lymphocytes demonstrate Na+/Ca2+ exchange activity and suggest the Na+/Ca2+ exchanger modulates cytosolic Ca2+ following intracellular Ca2+ store depletion.
Detection of Antigens Associated With Epstein-Barr Virus Replication in Extracts From Biopsy Specimens of Nasopharyngeal Carcinomas
Authors: J. Luka, Z. E. Deeb, D. P. Hartmann, B. Jenson, G. R. Pearson
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Detection of Antigens Associated With Epstein-Barr Virus Replication in Extracts From Biopsy Specimens of Nasopharyngeal Carcinomas Get access Janos Luka, Janos Luka 3Departments of Microbiology, George-town University Medical CenterWashington, DC. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ziad E. Deeb, Ziad E. Deeb 4Otolaryngology, George-town University Medical CenterWashington, DC. Search for other works by this author on: Oxford Academic PubMed Google Scholar Dan P. Hartmann, Dan P. Hartmann 5Pathology, George-town University Medical CenterWashington, DC. Search for other works by this author on: Oxford Academic PubMed Google Scholar Bennett Jenson, Bennett Jenson 5Pathology, George-town University Medical CenterWashington, DC. Search for other works by this author on: Oxford Academic PubMed Google Scholar Gary R. Pearson Gary R. Pearson * 3Departments of Microbiology, George-town University Medical CenterWashington, DC. *Correspondence to: Dr. Gary R. Pearson, Department of Microbiology, Medical-Dental Building, Third Floor, Georgetown University Medical School, 3900 Reservoir Rd., Washington, DC 20007. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 14, 21 September 1988, Pages 1164–1167, https://doi.org/10.1093/jnci/80.14.1164 Published: 21 September 1988 Article history Received: 25 March 1988 Revision received: 20 June 1988 Accepted: 29 June 1988 Published: 21 September 1988
Physician-to-Patient First Naming
Authors: A. P. Wilking
Journal: JAMA (1974)

To the Editor.—  I am writing in hopes that you will print this letter with whatever editorial comment you think appropriate.  For some years I have been mildly irked by the habit of numbers of doctors of calling their patients by their first names. In recent months, my annoyance at this practice has become more than mild. I am 58 years old, and I prefer to be called Mrs. Wilking unless I have a social as well as a professional acquaintance. A number of friends with whom I have discussed the situation feel exactly as I do.  Why do doctors do this? If it is an attempt to enhance their authority in a professional position, they should realize that what it does, instead, is set up a very unprofessional atmosphere and possibly, in some cases, even invites quite an awkward response from the patient. If it is an attempt to