A Therapeutic Dilemma
Authors: William G. Sanford, James R. Rasch, Robert B. Stonehill
Journal: Annals of Internal Medicine (1962)

Article1 April 1962A Therapeutic DilemmaThe Treatment of Disseminated Coccidioidomycosis with Amphotericin BWILLIAM G. SANFORD, JAMES R. RASCH, ROBERT B. STONEHILLWILLIAM G. SANFORD, JAMES R. RASCH, ROBERT B. STONEHILLAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-553 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptExcept in its disseminated form, coccidioidomycosis is a benign pulmonary disorder which is endemic in the southwestern part of the United States. The disseminated or progressive primary form has a fatality rate of more than 50% and requires vigorous, if not heroic, treatment (1). Although amphotericin B is relatively toxic, it has become recognized as the most effective antifungal agent for this disorder. The occurrence of transient azotemia has been reported repeatedly with amphotericin B. However, with relatively low dosages, permanent renal damage has not been reported generally. The experience at the USAF Hospital Lackland with six cases of disseminated...References1. WINN WA: The use of amphotericin B in the treatment of coccidioidal disease. Amer. J. Med. 27: 617, 1959. CrossrefMedlineGoogle Scholar2. LOURIA DB: Some aspects of the absorption, distribution, and excretion of amphotericin B in man. Antibiot. Med. 5: 295, 1958. Google Scholar3. HARRELLBOCABO ERFC: Modern treatment of the systemic fungus diseases. Clin. Pharmacol. Ther. 1: 104, 1960. CrossrefGoogle Scholar4. LITTMANHOROWITZSWADEY MDPLJG: Coccidioidomycosis and its treatment with amphotericin B. Amer. J. Med. 24: 568, 1958. CrossrefMedlineGoogle Scholar5. PERRYKIRBY DMWM: Acute disseminated coccidioidomycosis: two cases treated with amphotericin B. Arch. Intern. Med. 105: 929, 1960. CrossrefMedlineGoogle Scholar6. COLWELL JA: Remission in disseminated coccidioidomycosis produced by amphotericin B. Ann. Intern. Med. 50: 1028, 1959. LinkGoogle Scholar7. HUNTERMONGAN RCES: Disseminated coccidioidomycosis treated with amphotericin B. U. S. Armed Forces Med. J. 9: 1474, 1958. MedlineGoogle Scholar8. SMITHSAITOSIMONS CEMTSA: Pattern of 39,500 serologic tests in coccidioidomycosis. J. A. M. A. 160: 546, 1956. CrossrefMedlineGoogle Scholar9. SMITHSAITOBEARDKEPPCLARKEDDIE CEMTRRRMRWBV: Serologic tests in diagnosis and prognosis of coccidioidomycosis. Amer. J. Hyg. 52: 1, 1950. MedlineGoogle Scholar10. RHOADESGINNMUCHMORESMITHHAMMARSTEN ERHEHGWOJF: Effect of amphotericin B upon renal function in man. Clin. Research 8: 232, 1960. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Department of Medicine, USAF Aerospace Medical Center, Lackland Air Force Base, Texas.This paper represents the personal viewpoint of the authors and is not to be construed as a statement of official Air Force policy.Requests for reprints should be addressed to Captain James R. Rasch, USAF (MC), USAF Hospital Lackland, USAF Aerospace Medical Center (AFSC), Lackland Air Force Base, Texas. 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HILL II, M.D.CRYPTOCOCCOSIS (TORULOSIS) : SOME PROBLEMS IN DIAGNOSIS AND MANAGEMENTQuadriplegia Caused by Involvement of Cervical Spine with Coccidioides immitisAmphotericin B Nephrotoxicity with Irreversible Renal FailureFRANK J. TAKACS, M.D., ZYGMUNT M. TOMKIEWICZ, M.D., JOHN P. MERRILL, M.D., F.A.C.P.Coccidioidomycosis and Amphotericin BThe Renal Lesion Related to Amphotericin B Treatment for CoccidioidomycosisInfectious Diseases: Annual Review of Significant Publications 1 April 1962Volume 56, Issue 4Page: 553-563KeywordsAmphotericinAnemiaAntifungalsCoccidioidomycosisGratitudePrevention, policy, and public health Issue Published: 1 April 1962 PDF DownloadLoading ...