tbuckley/cabot-search huggingface dataset:
Pulmonary Alveolar Proteinosis
Authors: Cedrig L. Mather, Giles B. Hamlin
Journal: New England Journal of Medicine (1965)

PULMONARY alveolar proteinosis has been described as a chronic disease of the lung with a characteristic histology but variable clinical manifestations. The course may be one of relentless progression to death from respiratory insufficiency in as little as three months, as in Case 14 of the original series of Rosen, Castleman and Liebow.1 At the other extreme is the report of Furst, Bell and Irons2 of an asymptomatic case discovered accidentally on x-ray study during a routine periodic examination.We have recently had the opportunity of following a patient with this disease from the original diagnosis through to apparent recovery. . . .
Ocular allergy: recognizing and diagnosing hypersensitivity disorders of the ocular surface
Authors: A. Leonardi, E. Bogacka, J. L. Fauquert, M. L. Kowalski, A. Groblewska, M. Jedrzejczak‐Czechowicz, S. Doan, F. Marmouz, P. Demoly, L. Delgado
Journal: Allergy (2012)

Abstract Ocular allergy includes several clinically different conditions that can be considered as hypersensitivity disorders of the ocular surface. The classification of these conditions is complex, and their epidemiology has not been adequately studied because of the lack of unequivocal nomenclature. Ocular allergy symptoms are often, but not always, associated with other allergic manifestations, mostly rhinitis. However, specific ocular allergic diseases need to be recognized and managed by a team that includes both an ophthalmologist and an allergist. The diagnosis of ocular allergy is usually based on clinical history and signs and symptoms, with the support of in vivo and in vitro tests when the identification of the specific allergic sensitization is required for patient management. The aims of this T ask F orce R eport are (i) to unify the nomenclature and classification of ocular allergy, by combining the ophthalmology and allergy A llergic R hinitis and its Impact on A sthma criteria; (ii) to describe current methods of diagnosis; (iii) to summarize the therapeutic options for the management of ocular allergic inflammation.
Impaired fibrinolytic capacity and early recurrent spontaneous abortion.
Authors: J C Gris, J F Schved, S Neveu, P Mares, P Aguilar-Martinez, D Dupaigne
Journal: BMJ (1990)

The psychological consequences of diets that restrict energy intake are disputed.Our observations suggest that irritability and waking early in the morning were common in the third week of the diet.Whether these behavioural changes were related to decreased plasma concentrations of tryptophan could be investigated by supplementing the diet with tryptophan.There would be considerable interest if supplementation improved the compliance with, and effectiveness of, dieting.Unfortunately, pharmaceutical preparations of trvptophan have been withdrawn because of their suspected association with the eosinophilia-myalgia syndrome."It may be feasible, however, to investigate the effect of supplementation with tryptophan byrmanipulating the dietary intake of tryptophan and other amin acids.Trptophan remains important to the understanding of the relation between food intake and brain function.We thank Norma Brearley for preparing the manuscript.
Reviews, Notes, and Listings: Pulmonary Medicine: Pulmonary Complications of Systemic Disease
Authors: Andrew H. Limper
Journal: Annals of Internal Medicine (1993)

Literature of Medicine15 August 1993Reviews, Notes, and Listings: Pulmonary Medicine: Pulmonary Complications of Systemic DiseaseAndrew H. LimperAndrew H. LimperMayo Clinic and Foundation, Rochester, MN 55905Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-4-199308150-00046 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Pulmonary Complications of Systemic DiseaseJohn F. Murray; ed. 708 pages. New York: Marcel Dekker, Inc.; 1992. $185.00.The well-trained subspecialist must not only master the workings of a particular organ system but must also understand the integration of that organ into the whole. Subspecialists must have ready access to information that can connect the impact of systemic illnesses with the structure and function of their area of interest. Pulmonary Complications of Systemic Disease provides timely information of the effects of systemic illnesses on the respiratory system.Most major textbooks used by pulmonologists and subspecialty trainees have sections covering this ... Author, Article, and Disclosure InformationAffiliations: Mayo Clinic and Foundation, Rochester, MN 55905 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 1993Volume 119, Issue 4Page: 352KeywordsAIDSInformation technologyLibrariesLungsPulmonary diseasesPulmonary medicineRespiratory systemSub-specialty careSystemic diseasesVentilators ePublished: 15 August 2000 Issue Published: 15 August 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Is biliary lithiasis associated with pancreatographic changes?
Authors: M Barthet, C Affriat, J P Bernard, P Berthezene, J C Dagorn, J Sahel
Journal: Gut (1995)

The aetiological role of biliary lithiasis for chronic pancreatitis remains controversial. Previous studies based on pancreatographic studies reported changes in the pancreatic duct system caused by biliary lithiasis. This study analysed retrospectively the endoscopic retrograde cholangiopancreatography of 165 patients presenting with biliary lithiasis and of 53 controls. Among the 165 patients, 113 had choledochal stones (53 with gall bladder stones, 50 had had a cholecystectomy, 10 with a normal gall bladder), 35 had gall bladder stones without choledochal stones, 17 had cholecystectomy for gall bladder stones. Pancreatograms were analysed by measuring the diameter of the pancreatic duct in the head, the body, and the tail of the pancreas, and evaluating the regularity of the main pancreatic duct and the presence of stenosis, the regularity or the dilatation of secondary ducts, and the presence of cysts. In addition, we established a score, based on the above parameters, by which pancreatograms were classified as normal or with mild, intermediate, moderate or severe abnormalities. A multivariate analysis (stepwise multiple discriminant analysis) was performed for age, sex, presence of gall stones, presence of choledochal stones. Patients were comparable with controls for sex, alcohol consumption but were younger (55 v 68 years, p < 0.01). In patients and in controls, the frequency of pancreatographic abnormalities increased significantly with age. The pancreatographic features of patients and controls were not significantly different. In the multivariate analysis, age was the only factor with significant predicting value for pancreatographic abnormalities. In conclusion, biliary lithiasis in itself is not an aetiological factor for chronic pancreatitis, older age being responsible for the abnormalities seen by pancreatography of patients with biliary lithiasis.
Correlation of IHC and FISH for ALK Gene Rearrangement in Non-small Cell Lung Carcinoma: IHC Score Algorithm for FISH
Authors: Eunhee S. Yi, Jennifer M. Boland, Joseph J. Maleszewski, Anja C. Roden, Andre M. Oliveira, Marie-Christine Aubry, Michele R. Erickson-Johnson, Bolette L. Caron, Yan Li, Hui Tang, Shawn Stoddard, Jason Wampfler, Kimary Kulig, Ping Yang
Journal: Journal of Thoracic Oncology (2011)
A COMPREHENSIVE PROGRAMME TO REDUCE THE INCIDENCE OF HEPATITIS B VIRUS INFECTION AND ITS SEQUELAE IN ALASKAN NATIVES
Authors: BrianJ. McMahon, WilliamL. Heyward, Donald Ritter, RobertB. Wainwright, EverettR. Rhoades, Elizabeth Tower, AnneP. Lanier, Clare Helminiak
Journal: The Lancet (1987)
Steatosis Is an Independent Predictor of Relapse Following Rapid Virologic Response in Patients With HCV Genotype 3
Authors: Samir R. Shah, Keyur Patel, Patrick Marcellin, Graham R. Foster, Michael Manns, Shyam Kottilil, Letha Healey, Erik Pulkstenis, G. Mani Subramanian, John G. McHutchison, Mark S. Sulkowski, Stefan Zeuzem, David R. Nelson
Journal: Clinical Gastroenterology and Hepatology (2011)
Meningitis caused by Haemophilus influenzae type b infection after epiglottitis.
Authors: J. E. Foweraker, M. R. Millar, I. Smith
Journal: BMJ (1989)

Straddle accidents 1 7 Fell astride climbing pole Linear bruise 2 cm long anteriorly on inner surface of left labium minus along line of pubic ramus 2 9 Fell astride arm of chair Severe bruising and swelling of clitoris and right labium majus 3 4
Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes
Authors: Vily Panoutsakopoulou, Katharina M. Huster, Nami McCarty, Evan Feinberg, Rijian Wang, Kai W. Wucherpfennig, Harvey Cantor
Journal: Journal of Clinical Investigation (2004)

The ability of autoreactive T cells to provoke autoimmune disease is well documented. The finding that immunization with attenuated autoreactive T cells (T cell vaccination, or TCV) can induce T cell–dependent inhibition of autoimmune responses has opened the possibility that regulatory T cells may be harnessed to inhibit autoimmune disease. Progress in the clinical application of TCV, however, has been slow, in part because the underlying mechanism has remained clouded in uncertainty. We have investigated the molecular basis of TCV-induced disease resistance in two murine models of autoimmunity: herpes simplex virus-1 (KOS strain)–induced herpes stromal keratitis and murine autoimmune diabetes in non-obese diabetic (NOD) mice. We find that the therapeutic effects of TCV depend on activation of suppressive CD8 cells that specifically recognize Qa-1–bound peptides expressed by autoreactive CD4 cells. We clarify the molecular interaction between Qa-1 and self peptides that generates biologically active ligands capable of both inducing suppressive CD8 cells and targeting them to autoreactive CD4 cells. These studies suggest that vaccination with peptide-pulsed cells bearing the human equivalent of murine Qa-1 (HLA-E) may represent a convenient and effective clinical approach to cellular therapy of autoimmune disease.
Beyond the boundaries: relationship between general practice and complementary medicine.
Authors: P. C. Pietroni
Journal: BMJ (1992)

Traditional medical partnerships were designed to operate in a stable unchanging environment.It is clear that the next five years will be neither stable nor unchanging within primary health and community care.General practitioners for the first time are operating within a managed health service, and the autonomy they once had to determine their administrative routines is rapidly disappearing.These changes will inevitably challenge the organisational structures currently found in general practice.Inevitably, nurses, social workers, counsellors, midwives, health visitors, and dieticians will demand a place within an integrated health care team, and
Doctor's hunger strike fails to win funds
Authors: C. Kovac, A. Hajnal
Journal: BMJ (1998)

The cardiac surgery department of a county hospital in western Hungary remains in financial difficulties despite a week long hunger strike by an eminent heart surgeon last month.

Dr Lajos Papp, professor of cardiology at the Medical University of Pecs, abandoned his hunger strike only after learning that some of his patients planned to take similar action and that the welfare ministry might provide additional funds for his department.

Dr Papp was instrumental in establishing the cardiac surgery department at Zala …
Abstract 4538: Semiquantitative detection of aberrant methylation as a tumor biomarker in the serum and plasma of patients with gastric cancer
Authors: Jae-Hyuk Lee, Jin-Sook Kim, Kyung-Hwa Lee, Ji-Shin Lee, Chan Choi, Sang-Woo Juhng
Journal: Cancer Research (2012)

Abstract Background: Epigenetic silencing of tumor-related genes, due to CpG island methylation, is considered to be an important mechanism for the development of many tumors, including gastric cancinoma (GC). DNA methylation of multiple CpG sites in promoter regions of several tumor related genes, such as hMLH1, p14, COX2, and APC has been analyzed in GC so for. Circulating tumor DNA in serum/plasma has been demonstrated to reflect the biological characteristics of tumors. Recently, the presence of gene promoter methylation in serum/plasma DNA has also been demonstrated in patients with cancers of lung, head and neck, liver, and breast. So, in the present study, we attempted to determine the feasibility and the clinical correlations of detecting tumor-associated aberrant methylation in the serum/plasma of patients with gastric cancer. Materials and Methods: We examined promoter methylation of 6 genes using methylation-specific PCR (MSP) and methylation-sensitive high-resolution melting (MS-HRM) in paired serum, plasma and tumor samples of 50 gastric cancer patients. The tumor and the paired serum/plasma were investigated for aberrant methylation in BLU, DAPK1, GADD45G, MGMT, p15 and p16. The sensitivity of the HRM analysis was tested by using dilutions of fully methylated DNA into unmethylated DNA. Results: MSP was used to assess gene methylation in tumor samples. Promoter methylation in BLU, DAPK1, GADD45G, MGMT, p15, and p16 were detected in 47%, 37%, 59%, 32%, 14%, and 43% of tumor tissues by MSP. MS-HRM was used to assess gene methylation in serum/plasma samples concurrently. In the serum/plasma of gastric cancer patients, BLU, DAPK1, GADD45G, MGMT, p15, and p16 were methylated at frequencies of 26%, 21%, 23%, 11%, 9%, and 17%, respectively. Nineteen (38%) gastric tumor samples displayed concurrent methylation in three or more tumor genes. Aberrant methylation in one or more genes was found in 74% (37/50) serum samples and 70% (35/50) plasma samples. However, there was not a significant relationship of gene methylation between gastric tumor tissues and serum/plasma samples.Conclusion: These results suggest that aberrant promoter methylation in serum/plasma can be detected in a substantial proportion of gastric cancer patients. Detection of DNA methylation in serum/plasma may be a biomarker for early detection of gastric cancer. MS-HRM is powerful technique for the analysis of promoter methylation. Application of HRM analysis to large amount of clinical samples proves to be a fast and high-throughput way to investigate the epigenetic status of genes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4538. doi:1538-7445.AM2012-4538
Atrial fibrillation-associated minK38G/S polymorphism modulates delayed rectifier current and membrane localization
Authors: J EHRLICH, S ZICHA, P COUTU, T HEBERT, S NATTEL
Journal: Cardiovascular Research (2005)

Atrial fibrillation (AF) is a common acquired arrhythmia with multi-factorial pathogenesis. Recently, a single nucleotide polymorphism (SNP, A/G) at position 112 in the KCNE1 gene, resulting in a glycine/serine amino acid substitution at position 38 of the minK peptide, was associated with AF occurrence (AF more frequent with minK38G); however, the functional effect of this SNP is unknown.We used patch clamp recording, confocal microscopy and protein biochemistry to study the effect of this SNP on delayed-rectifier current expression and mathematical simulation to identify potential functional consequences. The density of slow delayed rectifier current (I(Ks)) resulting from co-expression with KvLQT1 was smaller with minK38G (e.g. at +10 mV: 50+/-7 pA/pF in Chinese hamster ovary (CHO) cells, 45+/-14 pA/pF for COS-7 cells) compared to minK38S (93+/-17 pA/pF, 104+/-23 pA/pF, respectively, P<0.05 for each). I(Ks) kinetics and voltage-dependence were unaffected. Currents resulting from co-expression of human ether-a-go-go-related gene (HERG) were similar for minK38G and minK38S, e.g. upon repolarization from +10 to -50 mV: tail currents 23+/-4 pA/pF versus 22+/-5 pA/pF (P=ns). KvLQT1 membrane immunofluorescence was less in CHO cells co-expressing minK38G versus minK38S, and surface expression of KvLQT1, as determined by labelling with streptavidin/biotin, was increased with minK38S co-expression. Computer simulations with a human atrial action potential model predicted that the minK38G SNP would slightly prolong the atrial action potential and reduce the frequency for alternans behaviour. In the presence of reduced repolarization reserve, these effects were enhanced and under specific conditions early afterdepolarizations occurred.The minK38G isoform is associated with reduced I(Ks), likely due to decreased KvLQT1 membrane expression. This study reveals a novel amino acid determinant of the minK-KvLQT1 interaction, and if the role of minK38G in AF is confirmed, would suggest mechanistic heterogeneity in genetic determinants of AF.
Measurements of total body and extracellular water in cirrhotic patients with and without ascites
Authors: Arthur J. McCullough, Kevin D. Mullen, Satish C. Kalhan
Journal: Hepatology (1991)

Using H2[18O] tracer isotope dilution and corrected bromide space as standard reference techniques, we determined total body water and extracellular water in cirrhotic patients with (four men and four women) and without (seven men and six women) ascites and compared them with a normal control group (eight men and six women). These results were then compared with calculations of total body and extracellular water determined by the bioelectrical impedance analysis technique. According to H2[18(O)] dilution, total body water was similar in cirrhotic patients without ascites and in controls (60.8% +/- 2.1% vs. 60.3% +/- 1.4% body wt), but was increased in patients with ascites (69.7% +/- 1.2% body wt; p less than 0.002). Correlation was excellent between the H2[18(O)] dilution and bioelectrical impedance measurements of total body water in controls and cirrhotic patients without ascites (r = 0.98; p less than 0.0001). However, this correlation was poor in cirrhotic patients with ascites (r = 0.17; not significant). According to the bromide space, extracellular water (expressed as a percentage of total body water) was increased in cirrhotic patients with (57.8% +/- 1.8%; p less than 0.001) and without (44.0% +/- 1.2%; p less than 0.001) ascites compared with controls (36.6% +/- 1.0%). A poor correlation (r = 0.41; p less than 0.13) was seen for extracellular water measurements between the bromide space method and the bioelectrical impedance method, which failed to detect the differences among the three groups observed with the bromide space technique. Furthermore, bioelectrical impedance failed to detect any change in total body or extracellular water after paracentesis, with a degree of inaccuracy that increased linearly as the amount of ascitic fluid removed increased (r = 0.97; p less than 0.001). All these intergroup comparisons remained the same, whether the analysis was of both men and women combined or for each gender individually. However, we saw differences between men and women in the control group and cirrhotic group without ascites. These results demonstrate that abnormalities in water homeostasis and compartmentalization between intracellular (the difference between total body and extracellular water fluid) and extracellular water may exist in cirrhosis whether or not fluid accumulation is clinically evident. These data further indicate that alterations in the metabolically active body cell mass (as represented by intracellular water) in cirrhosis may occur independently of total body water and calculated fat-free body mass. In addition, gender is an important variable to control for in studies of this type.(ABSTRACT TRUNCATED AT 400 WORDS)
Abstract 2518: Structure-activity relationships of folate-vinca alkaloid conjugates
Authors: Christopher P. Leamon, Iontcho R. Vlahov, Joseph A. Reddy, Marilynn Vetzel, Hari K. Santhapuram, Fei You, Alicia Bloomfield, Ryan Dorton, Melissa Nelson, Paul Kleindl, Jeremy Vaughn, Elaine Westrick
Journal: Cancer Research (2011)

Abstract EC145 is a potent folate-targeted vinca alkaloid conjugate that has been evaluated in 2 single agent phase 2 trials (ovarian and non small cell lung cancers) and 1 randomized open labeled phase 2 study in combination with DOXIL® in women with platinum-resistant ovarian cancer. Results from all of these trials have looked promising, and they support the continued evaluation of EC145 in a planned phase 3 trial that's expected to begin in early 2011. Structurally, EC145 consists of 4 essential modules: 1) folic acid, 2) a hydrophilic peptide spacer, 3) a disulfide-containing, self-immolative linker, and 4) the microtubule destabilizer, desacetylvinblastine hydrazide (DAVLBH). Due to EC145's potential for success, recent effort was given to determine the impact of i) substituting the DAVLBH vinca alkaloid unit in EC145 with analogs of vincristine, vindesine or vinorelbine, ii) substituting the naturally (S)-configured Asp-Arg-Asp-Asp-Cys peptide spacer in EC145 with (R)-configured amino acids placed in selective locations, and iii) varying the composition of the linker module to evaluate the impact of having a readily releasable, self-immolative linker system (e.g. disulfide-based as found in EC145) versus a more stable linker system (e.g. a thioether). New conjugates were screened in vitro against folate receptor-positive cells, and their cytotoxic activities were directly compared to that produced by EC145. Our data show that only DAVLBH-containing folate conjugates were active; thus, conjugates built with vincristine, vindesine or vinorelbine failed to produce activity when cells were exposed to concentrations as high as 1 µM. Within the DAVLBH series, having a bio-releasable, self-immolative linker system was found to be critical for activity since multiple analogs constructed with thioether-based linkers failed to produce meaningful activity both in vitro and in vivo. Substitutions of some or all of the natural amino acids within EC145's hydrophilic spacer module was not found to significantly change the in vitro potency of the conjugate; however, some enhancement in anti-tumor activity was measurable when tested in vivo against well-established subcutaneous folate receptor-positive tumor xenografts. Despite these modest improvements, EC145 remains as one of the more potent folate-vinca alkaloid conjugates produced to date, and continued clinical development is therefore warranted. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2518. doi:10.1158/1538-7445.AM2011-2518
Kawasaki-like Disease in a Young Adult
Authors: Alan G. Barbour
Journal: JAMA (1979)

KAWASAKI disease (mucocutaneous lymph node syndrome) is an acute febrile illness of unknown cause, which is usually seen in young children.<sup>1</sup>A young asplenic adult had the features of Kawasaki disease occurring in association with heterophilantibody-negative Epstein-Barr virus infectious mononucleosis. Modification of the immune response to Epstein-Barr virus by asplenia may have led to this unusual presentation of infectious mononucleosis. <h3>Report of a Case</h3> An 18-year-old white man who was working for the summer as a poultry butcher was admitted on Sept 1 with a 15-day history of headache, fever, and rash. He had undergone splenectomy following trauma at age 13 years. The Figure summarizes the clinical course. On the day of onset of illness, chills, myalgias, sore throat, and headache developed, and a bright-red face and lips were noted. On the third day, a physician noted cervical lymphadenopathy and pharyngitis and prescribed oral penicillin V potassium for suspected