tbuckley/cabot-search huggingface dataset:
Coagulant proteins and thrombin generation in synovial fluid: A model for extravascular coagulation
Authors: Ping Chang, David L. Aronson, David G. Borenstein, Craig M. Kessler
Journal: American Journal of Hematology (1995)

Abstract The coagulant content and thrombin generating potential of synovial fluid from patients with osteoarthritis were studied as a model of extravascular coagulation. The concentrations of individual coagulant proteins were partially correlated with their molecular weight. The levels of the very large coagulants factor V, factor VIII and von Willebrand factor antigen (vWF:ag) are less than 1% of the activities found in a normal pooled reference plasma while smaller coagulants including factors IX, XI and prothrombin range between 9 and 30%. The protease inhibitors antithrombin‐III (AT‐III) and Alpha‐2 macroglobulin in synovial fluid were present at levels of 74% and 13% of plasma, higher than expected based on their molecular weights. Prothrombin was more rapidly activated by tissue thromboplastin than by aPTT reagent. The thrombin activity formed in synovial fluid decreased more rapidly than that formed in dilute plasma. The addition of recombinant factor VIII or bovine factor V to synovial fluid accelerated the thrombin production by APTT but not by tissue thromboplastin. Indicating that the low levels of factor VIII and factor V did limit the rate of thrombin production. The addition of specific antibodies to factor VIII or factor V strongly inhibited thrombin production by aPTT. These data confirm a roughly inverse relationship between the concentrations of coagulation proteins and their molecular weight in synovial fluid and indicate that thrombin can be generated in synovial fluid. The inactivation of thrombin in synovial fluid may be more dependent on antithrombin‐III than in plasma because of the increased AT‐III/alpha‐2 macroglobulin ratio seen in synovial fluid.
Prevalence of Psychiatric Disorders in an Italian Town: Low Prevalence Confirmed with Two Different Interviews
Authors: Antonella Gigantesco, Gabriella Palumbo, Fiorino Mirabella, Mario Pettinelli, Pierluigi Morosini
Journal: Psychotherapy and Psychosomatics (2006)

&lt;i&gt;Background:&lt;/i&gt; In Italy, few studies on the prevalence of psychiatric disorders have considered all of the most common disorders and very few have adopted the most common tools, that is, the Composite International Diagnostic Interview (CIDI) and the Present State Examination (PSE). The objective of the present study was to estimate the prevalence of psychiatric disorders and its correlates in the town of Jesi, Italy, using the PSE and CIDI, administered 7 years apart. &lt;i&gt;Methods:&lt;/i&gt; The two surveys were conducted among adults in Jesi (central Italy), using the PSE in 1993 and the CIDI in 2000. Participants were randomly chosen from the patient lists of general practitioners. &lt;i&gt;Results:&lt;/i&gt; The one-month prevalence of persons with a psychiatric disorder was 7.3% (95% CI: 4.4–11.6) in 1993 and 6.0% (95% CI: 3.5–9.5) in 2000. The lifetime and 1-year prevalence rates were 21.0 and 8.2%, respectively. The most common disorders were depressive and anxiety disorders. Mood and anxiety disorders were more common among women and unmarried persons. &lt;i&gt;Conclusions:&lt;/i&gt; The prevalence is lower than that in most other areas of the world yet consistent with estimates for Italian populations reported by studies using the same (or similar) tools.
Acute Decreases in Proteasome Pathway Activity after Inhalation of Fresh Diesel Exhaust or Secondary Organic Aerosol
Authors: Howard M. Kipen, Sampada Gandhi, David Q. Rich, Pamela Ohman-Strickland, Robert Laumbach, Zhi-Hua Fan, Li Chen, Debra L. Laskin, Junfeng Zhang, Kiran Madura
Journal: Environmental Health Perspectives (2010)

Epidemiologic studies consistently demonstrate an association between acute cardiopulmonary events and changes in air pollution; however, the mechanisms that underlie these associations are not completely understood. Oxidative stress and inflammation have been suggested to play a role in human responses to air pollution. The proteasome is an intracellular protein degradation system linked to both of these processes and may help mediate air pollution effects.
Glutathione S-transferases in alcoholic liver disease.
Authors: D J Harrison, L May, P C Hayes, M M Haque, J D Hayes
Journal: Gut (1990)

There is already evidence in alcoholic liver disease, mostly from studies of morphology and cytokeratin distribution, that hepatocytes can undergo a variety of phenotypic changes. This study reports findings of immunohistochemistry using antibodies against members of the glutathione S-transferase supergene family of detoxification enzymes. Hepatocytes in severe alcoholic liver disease coexpressed both alpha and pi class glutathione S-transferase. This coexpression has been previously described only in human fetal liver and in chemically-induced preneoplastic foci in rat liver. The use of function associated markers should provide additional information in the investigation of liver disease.
Acupuncture: Failure to Relieve Deafness
Authors: Hugh H. Hussey
Journal: JAMA (1974)

Only a few states and the District of Columbia permit acupuncture by non-MDs. Following some anecdotal remarks about the value of such therapy in nerve deafness and a series of UPI news releases on the subject, enormous interest resulted. Deaf persons flocked to acupuncturists, especially to those practicing in six centers in Washington, DC. Consequently, the Otolaryngology Section of the Medical Society of the District of Columbia requested Fairbanks and his colleagues1to evaluate acupuncture therapy for nerve deafness. The authors describe the activities of the six Washington acupuncture centers as follows:  One of them processes up to 100 patients each day, 90% of whom are seeking a cure for deafness. Patients come from widely scattered parts of the United States. Travel and housing in local hotels are major expenses. One center reserves hotel rooms for its patients in one location and provides a limousine shuttle to and from
Inflammasome activation and vitiligo/nonsegmental vitiligo progression
Authors: J. Marie, D. Kovacs, C. Pain, T. Jouary, C. Cota, B. Vergier, M. Picardo, A. Taieb, K. Ezzedine, M. Cario-André
Journal: British Journal of Dermatology (2014)

Journal Article Inflammasome activation and vitiligo/nonsegmental vitiligo progression Get access J. Marie, J. Marie National Reference Centre for Rare Skin Diseases Hôpital St André CHU de Bordeaux France Search for other works by this author on: Oxford Academic Google Scholar D. Kovacs, D. Kovacs IRCCS San Gallicano Dermatological Institute Rome Italy Search for other works by this author on: Oxford Academic Google Scholar C. Pain, C. Pain National Reference Centre for Rare Skin Diseases Hôpital St André CHU de Bordeaux FranceUniversity Bordeaux 146 rue Léo Saignat Bordeaux 33076 FranceINSERM U1035 Biothérapie des Maladies Génétiques et Cancers Bordeaux France Search for other works by this author on: Oxford Academic Google Scholar T. Jouary, T. Jouary National Reference Centre for Rare Skin Diseases Hôpital St André CHU de Bordeaux France Search for other works by this author on: Oxford Academic Google Scholar C. Cota, C. Cota IRCCS San Gallicano Dermatological Institute Rome Italy Search for other works by this author on: Oxford Academic Google Scholar B. Vergier, B. Vergier Laboratory of Pathology Hôpital du Haut‐Lévêque CHU de Bordeaux France Search for other works by this author on: Oxford Academic Google Scholar M. Picardo, M. Picardo IRCCS San Gallicano Dermatological Institute Rome Italy Search for other works by this author on: Oxford Academic Google Scholar A. Taieb, A. Taieb National Reference Centre for Rare Skin Diseases Hôpital St André CHU de Bordeaux FranceUniversity Bordeaux 146 rue Léo Saignat Bordeaux 33076 FranceINSERM U1035 Biothérapie des Maladies Génétiques et Cancers Bordeaux France Search for other works by this author on: Oxford Academic Google Scholar K. Ezzedine, K. Ezzedine National Reference Centre for Rare Skin Diseases Hôpital St André CHU de Bordeaux FranceUniversity Bordeaux 146 rue Léo Saignat Bordeaux 33076 FranceINSERM U1035 Biothérapie des Maladies Génétiques et Cancers Bordeaux France Search for other works by this author on: Oxford Academic Google Scholar M. Cario‐André M. Cario‐André National Reference Centre for Rare Skin Diseases Hôpital St André CHU de Bordeaux FranceUniversity Bordeaux 146 rue Léo Saignat Bordeaux 33076 FranceINSERM U1035 Biothérapie des Maladies Génétiques et Cancers Bordeaux France Correspondence Muriel Cario‐André. E‐mail: muriel.cario---andre@u-bordeaux.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 170, Issue 4, 1 April 2014, Pages 816–823, https://doi.org/10.1111/bjd.12691 Published: 01 April 2014
Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia
Authors: Vincent T. Bicocca, Bill H. Chang, Behzad Kharabi Masouleh, Markus Muschen, Marc M. Loriaux, Brian J. Druker, Jeffrey W. Tyner
Journal: Cancer Cell (2012)
The Chediak-Higashi Syndrome: Studies of Host Defenses
Authors: SHELDON M. WOLFF
Journal: Annals of Internal Medicine (1972)

A striking clinical feature of the Chediak-Higashi syndrome (CHS) is a markedly increased susceptibility to pyogenic infections. Recent investigations have documented multiple defects in host defenses in patients with the syndrome. Neutropenia, a characteristic finding, is most likely related to intramedullary destruction of granulocytes. Defective leukocyte migration has been found in vivo by the skin window technique, and a cellular defect in Chemotaxis has been documented in vitro. Although phagocytosis is quantitatively normal, there is a failure in postphagocytic degranulation, as well as diminished intracellular bactericidal capacity, findings that may be related to ineffective delivery of lysosomal contents to the phagocytic vacuole. An abnormal distribution and reduced quantities of lysosomal enzymes have been shown. Some or all of these deficiencies in leukocyte regulation, structure, and function may contribute to the increased susceptibility to bacterial infections.
Treatment of Raynaud's phenomenon with the 5-HT2-receptor antagonist ketanserin.
Authors: E Stranden, O K Roald, K Krohg
Journal: BMJ (1982)

The selective 5-hydroxytryptamine2-(5-HT2)-receptor-blocking agent ketanserin was given in a dose of 10 mg intravenously to nine patients with Raynaud9s phenomenon. The effect on blood flow was assessed by photopletysmography and measurments of skin temperature. Digital blood flow and skin temperature increased significantly after ketanserin injection, whereas the placebo (saline 9 g/l) had no such effect. This study suggests that ketanserin may be useful in the treatment of Raynaud9s phenomenon.
The Hand of God
Authors: T. Stammers
Journal: BMJ (2011)

The Hand of God is a classic but not because of its beautiful writing. The prose is often painful, and even the author acknowledges his rambling style, with comments like, “But I’m getting ahead of myself.” Some classic novels transport us into other worlds or times: this book deals with the current reality of industrialised abortion. Other classics depend on the author’s fame, but though Bernard Nathanson’s infamy merited a whole page obituary in the BMJ, I doubt if he will ever crop up in a pub quiz
Disobliterative Endarteriectomy of External Iliac Artery
Authors: F. Forty
Journal: BMJ (1952)

BEDIdeepened to healthy tissues, it will usually be possible to apply immediate split-skin grafts.After two weeks further grafts may be advisable.In spite of the use of the methods outlined, final healing of extensive lesions often takes three months.With experience this time can be reduced to a minimum.When final healing does occur the skin is often puckered and scarred.This may be so severe that a flap or pedicle graft is required, especially if any further operation becomes necessary in the involved area.In this short series, two feet have required cross-leg flaps for this reason. I Summary and ConclusionsThe open and closed varieties of friction injuries sustained in road accidents have been described and the importance of careful treatment has been stressed.The open lesion is quite common, but good judgment is of great importance in its management.The antibiotics have made surgical treatment and early skin- grafting safer.The closed lesion is rarer.If it is not recognized early, skin gangrene may be found when a plaster is removed.Medico-legally, it is important to realize that bandaging and splintage have in no way been responsible.
Strain Rate Imaging for Assessment of Regional Myocardial Function
Authors: Theodore P. Abraham, Rick A. Nishimura, David R. Holmes, Marek Belohlavek, James B. Seward
Journal: Circulation (2002)

Background — Regional myocardial function assessment is essential in the management of coronary artery disease (CAD). Tissue Doppler imaging (TDI) by depicting local myocardial motion can potentially quantify regional myocardial function. Strain rate imaging (SRI) that depicts regional deformation is less susceptible to cardiac translation and tethering and may be superior to TDI for regional function analysis. We examined regional myocardial function using TDI and SRI in a unique clinical model of a small, discrete myocardial infarction. Method and Results — Ten patients with severely symptomatic septal hypertrophy underwent basal septal ablation via intracoronary alcohol injection and had TDI and SRI pre- and postablation. Invasive hemodynamics showed no appreciable change in global function. Peak systolic strain rate was significantly lower postablation versus preablation (−0.5 versus −1.2 s −1 , P &lt;0.001) and when comparing infarct and noninfarct areas (−0.5 versus −1.5 s −1 , P &lt;0.001). In contrast, peak systolic tissue velocities were similar pre- and postablation (3.9 versus 2.9 cm/s, P =0.16) and between infarct and noninfarct areas (2.9 versus 2.2 cm/s, P =0.13). SRI analysis demonstrated reduced systolic function in the peri-infarct zone and preserved systolic function in the remote nonischemic zone. Conclusion — In the clinical setting of a small, discrete infarct unaccompanied by changes in global function, SRI accurately depicted changes in regional function. These data suggest that SRI may be the optimal method for objective, quantitative assessment of regional myocardial dysfunction.
Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status
Authors: Su Melser, Etienne Hébert Chatelain, Julie Lavie, Walid Mahfouf, Caroline Jose, Emilie Obre, Susan Goorden, Muriel Priault, Ype Elgersma, Hamid Reza Rezvani, Rodrigue Rossignol, Giovanni Bénard
Journal: Cell Metabolism (2013)
FDA Offers Advice to Reduce Risks of Long-Acting β-Agonists in Asthma Care
Authors: Bridget M. Kuehn
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Case 22-1976
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, John W. Strieder, Eugene J. Mark
Journal: New England Journal of Medicine (1976)

Presentation of Case First admission. A 50-year-old woman was admitted to the hospital because of a pulmonary lesion.She was well until three months earlier, when a cough productive of yellow sputum developed, and she began to experience fatigue and mild weakness. A physician found that her tuberculin skin test had converted to positive. Five weeks before admission she entered another hospital, where repeated smears of sputum for tubercle bacilli and fungi were negative. Ten days before entry bronchoscopic examination disclosed a friable, obstructing mass within the left main-stem bronchus; cytologic examination of bronchial washings was negative; a biopsy . . .
Medical Therapy of Acute Myocardial Infarction by Application of Hemodynamic Subsets
Authors: James S. Forrester, George Diamond, Kanu Chatterjee, H. J. C. Swan
Journal: New England Journal of Medicine (1976)

In the broadest sense, current hospital therapy of acute myocardial infarction attempts to prevent, or promptly and effectively treat, the electrical and mechanical consequences of regional myocardial ischemia or infarction, while preserving jeopardized ischemic myocardium. Prevention and effective therapy of arrhythmias have largely been realized through the development of coronary-care units. The goals of prompt and effective therapy of disordered cardiac function and preservation of ischemic muscle, although far from achieved, have been greatly advanced in the past several years by the widespread use of hemodynamic monitoring. As a result, new concepts concerning the disease itself and new therapies have . . .
Patterns of incidence in acute pancreatitis.
Authors: J E Trapnell, E H Duncan
Journal: BMJ (1975)

A review of acute pancreatitis occurring over a 20-year period in the Bristol clinical area is reported. A total of 590 cases were available for analysis. The yearly incidence was 53-8 per million population at risk, with a mortality of 9-0 per million. This compares favourably with 11-4 deaths per million for England and Wales as a whole during the same period but the difference is not statistically significant. When the deaths occurring in the Bristol clinical area were expressed in terms of case mortality rate the figure was 17%. In contrast the mortality for recurrent acute pancreatitis was only 1-5%, and the benign nature of this second condition is confirmed. Aetiological factors and age and sex distribution were also analysed in relation to each other and to mortality. An increase in acute pancreatitis secondary to chronic alcoholism was confirmed and steroid pancreatitis also emerged as a definite entity in this survey. The pattern of recurrence in patients with idiopathic pancreatitis was studied in detail and is analysed on an actuarial basis.
Quick and Limited Is Better Than Slow, Sloppy, or Sly
Authors: Wynne Morrison, Chris Feudtner
Journal: The American Journal of Bioethics (2011)

Should clinicians and ethicists reconsider the appropriateness of the “slow code”? Drs. Lantos and Meadow (2011) argue in this issue of AJOB that many patients and families accept that death is nea...
Abstract 2842: CCL2 recruits inflammatory monocytes to facilitate breast tumor metastasis
Authors: Binzhi Qian, Jiufeng Li, Hui Zhang, Jinghang Zhang, Linda A. Snyder, Jeffrey W. Pollard
Journal: Cancer Research (2011)

Abstract Macrophages are abundant in the tumor microenvironment and enhance malignancy through their promotion of angiogenesis and invasion at the primary tumor site as well as extravasation, target organ seeding and persistent growth at distant metastatic sites. To determine the origin and recruitment of tumor associated macrophages, different populations of monocytes were FACS sorted and adoptively transferred into mice bearing MMTV-PyMT induced mouse mammary tumors with or without spontaneous pulmonary metastases. Ly6C+ inflammatory monocytes were preferentially recruited to pulmonary metastases but not primary tumors in a CCL2 (also known as MCP1) dependent manner. Human inflammatory monocytes were also preferentially recruited to pulmonary metastases of human breast cancer cells in immuno-compromised mice in a CCL2 dependent manner. These inflammatory monocytes promote tumor cell trans-endothelial migration in vitro, a process that is abrogated by an anti-CCL2 neutralizing antibody. Neutralizing CCL2 in vivo blocks the recruitment of metastasis associated macrophages and their direct interaction with metastasizing tumor cells, leading to inhibition of tumor cell extravasation and metastatic seeding. Inhibition of tumor cell-derived CCL2 inhibits their metastatic seeding. Secretory factors from inflammatory monocytes were identified to mediate their metastasis-promoting function in vitro and in vivo. Both CCL2 expression and macrophage infiltration are correlated with poor prognosis in human breast cancer. Our data strongly suggest that recruitment of Ly6C+ inflammatory monocytes is the mechanistic link between these two clinical associations and suggests new therapeutic targets for treating metastatic breast disease. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2842. doi:10.1158/1538-7445.AM2011-2842
Molecularly Targeted Therapies in Non–Small-Cell Lung Cancer Annual Update 2014
Authors: Daniel Morgensztern, Meghan J. Campo, Suzanne E. Dahlberg, Robert C. Doebele, Edward Garon, David E. Gerber, Sarah B. Goldberg, Peter S. Hammerman, Rebecca S. Heist, Thomas Hensing, Leora Horn, Suresh S. Ramalingam, Charles M. Rudin, Ravi Salgia, Lecia V. Sequist, Alice T. Shaw, George R. Simon, Neeta Somaiah, David R. Spigel, John Wrangle, David Johnson, Roy S. Herbst, Paul Bunn, Ramaswamy Govindan
Journal: Journal of Thoracic Oncology (2015)
Clinical evidence of efficient tumor targetting based on single–chain Fv antibody selected from a combinatorial library
Authors: R.H.J. Begent, M.J. Verhaar, K.A. Chester, J.L. Casey, A.J. Green, M.P. Napier, L.D. Hopestone, N. Cushen, P.A. Keep, C.J. Johnson, R.E. Hawkins, A.J.W. Hilson, L. Robson
Journal: Nature Medicine (1996)