tbuckley/cabot-search huggingface dataset:
Protein C survival during replacement therapy in homozygous protein C deficiency
Authors: Richard A. Marlar, Robert R. Montgomery, Renee M. Madden, Richard H. Sills, Paula K. Groncy
Journal: American Journal of Hematology (1992)

Abstract Homozygous protein C (PC) deficiency is a rare genetic defect that usually results in fatal thrombotic complications (purpura fulminans and DIC), but it can be successfully managed with oral anticoagulants or PC replacement. The successful use of PC replacement for two individuals is described. The activity and antigen levels of PC in fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC) are also reported. The concentration of PC in FFP is 87 ± 15 units/dl. PC is present in all PCC analyzed; however, a ten‐fold difference between the various brands and/or lots is noted. The PC activity and antigen correlates well with no significant levels of APC. Upon infusion of FFP into two homozygous PC‐deficient children, the PC levels obtained were ≦30 units/dl post‐ infusion and undetectable after 12‐18 hr. With infusions of PCC, plasma levels of PC obtained were 100‐145 units/dl and &lt;10 units/dl after 48 hr. The percent recovery and half‐lives of PC from FFP and PCC were 49.8% and 7.8 hr, and 84% and 7.4 hr, respectively. One infant was treated every 48 hr for 2 years without significant purpura fulminans or DIC complications. The levels of the other PC system components did not change during the infusion of the PC‐rich material. Based on this information, a specific replacement protocol has been developed using a PC‐rich concentrate. However, several problems may arise with the „less pure”︁ PC‐rich concentrates: catheter‐tip thrombosis, related large vessel thrombosis and blood‐transmitted diseases. With a specific PC concentrate, replacement therapy is a viable alternative for the long‐term management/treatment of homozygous PC deficiency. © 1992 Wiley‐Liss, Inc.
Ephraim McDowell, "Father of Ovariotomy" and Founder of Abdominal Surgery. With an Appendix on Jane Todd Crawford.
Authors: August Schachner
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Venereal Infections in Children-Reply
Authors: Jennifer James
Journal: JAMA (1979)

We are in full agreement with the comments made by McClelland, Uyeki, Zemaityte, and Tinker. We plan in future articles to deal with examination procedures that include concern with (1) perception of abuse, (2) psychological state of the victim, (3) health concerns such as venereal disease, and (4) evidence documentation. Venereal infections in children are a classic sign of "sexual misuse." Our study concentrated on reporting issues but was in no way intended to slight the importance of other sexual misuse concerns. We appreciate that these authors brought the problem of venereal infection to the readership ofThe Journalbut do not feel the problem is an omission in our COMMENTARY. Our intent was to provide one more increment in the accumulation of knowledge about the problems associated with sexual abuse. There are many "serious omissions" that we hope will be written about by ourselves and our colleagues
The Ocular Surface of Glaucoma Patients Treated over the Long Term Expresses Inflammatory Markers Related to Both T-Helper 1 and T-Helper 2 Pathways
Authors: Christophe Baudouin, Hong Liang, Pascale Hamard, Luisa Riancho, Catherine Creuzot-Garcher, Jean-Michel Warnet, Françoise Brignole-Baudouin
Journal: Ophthalmology (2007)
Radiofrequency field exposure and cancer: what do the laboratory studies suggest?
Authors: M H Repacholi
Journal: Environmental Health Perspectives (1997)

Significant concern has been raised about possible health effects from exposure to radiofrequency (RF) electromagnetic fields, especially after the rapid introduction of mobile telecommunications systems. Parents are especially concerned with the possibility that children might develop cancer after exposure to the RF emissions from mobile telephone base stations erected in or near schools. These questions have followed scientific reports suggesting that residence near high voltage power lines may to be associated with an increased childhood leukemia risk. Epidemiologic studies have been plagued by poor RF exposure assessment and differences in methodology. There are no high-quality epidemiologic studies that can be used to evaluate health risks from RF exposure. Laboratory studies in this area have been somewhat confusing. Some animal studies suggest that RF fields accelerate the development of sarcoma colonies in the lung, mammary tumors, skin tumors, hepatomas, and sarcomas. A substantial RF-induced increase in lymphoma incidence in transgenic mice exposed for up to 18 months has also been reported. In contrast, other studies have not found carcinogenic effects. These conflicting results indicate the need for more well-conducted studies on laboratory animals, supplemented with high-quality in vitro studies to identify effects that need further research in vivo, and to characterize any acting mechanisms, especially at low RF field levels. This paper provides a review of the laboratory studies and indicates what conclusions about RF-induced cancer can be drawn.
Ponction à l'aiguille fine de masses pancréatiques sous échoendoscopie: performance diagnostique et impact thérapeutique
Authors: Y Touchefeu, M Le Rhun, J Geay, A Alamdari, MF Heymann, E Coron, T Matysiak-Budnik, C Masliah, JP Galmiche
Journal: Endoscopy (2008)

Introduction: Les lésions pancréatiques sont le plus souvent de petite taille, d'accès difficile, précancéreuses ou déjà malignes. La ponction à l'aiguille fine sous échoendoscopie (PAF) est une procédure dont la valeur diagnostique et l'impact thérapeutique ont été peu évalués. Le but de l'étude a été d'évaluer 1) la capacité de la PAF à recueillir un matériel suffisant pour l'histologie et la cytologie, 2) l'impact des résultats sur la prise en charge des patients.
Abstract 4965: Hypoxia has different effects on proliferation, migration and metastasis of various types of tumor cells
Authors: Enikő Tátrai, Alexandra Bartal, Zsuzsanna Fehér, Ákos Farkas, Sándor Paku, István Kenessey, József Tóvári
Journal: Cancer Research (2014)

Abstract Hypoxia promotes angiogenesis and assigns radio- and chemotherapy resistance and aggressive phenotype to tumor cells. HIF-1 alpha, the main regulator of hypoxia induced processes, is activated in areas of low oxygen supply. Rho GTPases such as Rac1, cdc42 and RhoA play an important role in actin polimerization, depolimerization and stress fiber formation during tumor morphogenesis, cell adhesion, and cell migration. In the present study cell lines of melanoma (HT168-M1), fibrosarcoma (HT1080), colon cancer (HT25, HT29), lung cancer (H1975) and a head-neck cancer (PECA-PJ15) were cultured under normoxic and hypoxic conditions containing 1% and 5% O2. Proliferation tests with sulforhodamine B, migration assays with modified Boyden chamber and time-lapse videomicroscopy were performed with all cell lines. Furthermore, investigation of the expression and localization of HIF-1alpha, Rac1, cdc42 and RhoA mRNA by quantitative RT-PCR and immunfluorescence and the activation of small GTPases were performed. In addition, we examined the role of the hypoxic condition (CoCl2 administration) and HIF blockade (chetomin administration) on the metastatic potential of tumor cells using orthotopic xenograft models. The various tumor cell lines displayed different behaviour in vitro and in vivo. In the case of the most motile cell line (HT-168-M1), proliferation and migration capacity, moreover the gene expression patterns of small GTPases and HIF-1alpha were significantly higher under hypoxic conditions compared to normoxic cells. Migration capacity of the PECA-PJ15 cell line was higher when cultured under higher oxygen concentration. The hypoxic condition was less tolerated by both human colon carcinoma cell lines. In HT29 cells RhoA translocated into the nucleus under the hypoxic condition. The in vivo experiments demonstrated that primary tumor size and the number of metastasis were the largest in the CoCl2-treated group, and the smallest in the chetomin-treated group. In conclusion, our findings support that different phenotypes of the cancer cells form under hypoxia presumably via different pathways. This work is supported by OTKA K84173. Citation Format: Enikő Tátrai, Alexandra Bartal, Zsuzsanna Fehér, Ákos Farkas, Sándor Paku, István Kenessey, József Tóvári. Hypoxia has different effects on proliferation, migration and metastasis of various types of tumor cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4965. doi:10.1158/1538-7445.AM2014-4965
Irreversible tide of technological advancement?
Authors: H. U Ahmed, M. Arya, M. Emberton
Journal: BMJ (2008)

Commenting on the systematic review by Lourenco et al,1 we wish to make several specific and general points.

The contention that holmium laser enucleation holds most promise in challenging transurethral prostatic ablation (TURP) belies the fact that this technique has a steep learning curve and requires careful morcellation of the prostate in the bladder once enucleated. …
Response of plasma and tissue endothelin-1 to liver ischemia and its implication in ischemia-reperfusion injury
Authors: Eisuke Kawamura, Naoki Yamanaka, Eizo Okamoto, Fumihito Tomoda, Kazutaka Furukawa
Journal: Hepatology (1995)

This study was designed to investigate the changes in plasma and tissue endothelin-1/endothelin-2 (ET) after liver ischemia and to assess the protective effect of anti-ET 1/ET 2 monoclonal antibody (ET antibody) against ischemia-reperfusion injury. The ET levels in the liver tissue, hepatic venous blood of the ischemic and non-ischemic sides, and in the portal venous blood were measured before and after partial liver ischemia for 1 hour in the adult dog. The ET levels in the liver tissue and hepatic venous blood on the ischemic side increased slightly during ischemia and markedly after reperfusion, whereas those on the nonischemic side showed no significant increases. The ET levels in the portal venous blood peaked at 1 to 3 hours after ischemia, which was significantly higher than the levels in the hepatic venous blood on the ischemic side and which correlated with the portal venous pressure elevated because of the partial liver clamping. The administration of antibody (2 mg/kg, intravenous) before reperfusion resulted in a significant inhibition of the postreperfusion elevations of serum-glutamic-oxaloacetic transaminase (GOT), S-glutamic pyruvic transaminase (GPT), and the indocyanine green (ICG) dye retention rate. In conclusion, ET was produced both in the liver tissue exposed to ischemia and in the vascular endothelium of the portal bed exposed to portal congestion. The ET released from the vascular endothelium, including the liver and the portal bed, was found to be a possible factor of ischemia-reperfusion injury.
Otolaryngological Aspects of Sjogren's Syndrome
Authors: J. A. Doig, K. Whaley, W. C. Dick, G. Nuki, J. Williamson, W. W. Buchanan
Journal: BMJ (1971)

Twenty-two patients with Sjögren9s syndrome uncomplicated by a connective tissue disorder, 31 with Sjögren9s syndrome complicated by rheumatoid arthritis, and 21 with rheumatoid arthritis alone were studied with particular reference to changes in the ears and in the upper respiratory and digestive tracts. Epistaxis, soreness and dryness of the throat, dysphagia, and hoarseness were common symptoms, and rhinitis sicca and postcricoid narrowing were not uncommon features of the Sjögren groups. Oesophagoscopy in one patient revealed a web identical to that found in Paterson/Brown Kelly syndrome; none of the patients, however, had an iron-deficiency anaemia or koilonychia. There was an increased frequency of deafness in all groups, and the deafness tended to be conductive in the Sjögren groups and sensorineural in the rheumatoid arthritis group.
Amplification of flecainide-induced ventricular conduction slowing by exercise. A potentially significant clinical consequence of use-dependent sodium channel blockade.
Authors: S Ranger, M Talajic, R Lemery, D Roy, S Nattel
Journal: Circulation (1989)

Proarrhythmic effects of flecainide acetate have been reported during exercise, but the mechanism for the arrhythmogenic interaction between flecainide and exercise is unknown. We hypothesized that the sinus tachycardia of exercise may enhance flecainide-induced conduction slowing by increasing use-dependent sodium channel blockade, thereby facilitating the occurrence of ventricular reentry. To evaluate the modulation of flecainide's effects by exercise, we studied 19 patients who were receiving therapeutic doses of flecainide for the treatment of cardiac arrhythmias. Sixteen patients underwent treadmill exercise testing by a modified Bruce protocol. During exercise, QRS duration increased progressively from 94 +/- 22 msec (mean +/- SD) at rest to 116 +/- 25 msec (p less than 0.001) at a mean heart rate increase of 84 +/- 32 beats/min. The patient with the greatest QRS increase developed a monomorphic ventricular tachycardia at peak exercise. At rest, the QRS duration after treatment with flecainide increased 12.1 +/- 10.0% compared with the pretreatment value, and with exercise, the QRS duration increased by a further 28.1 +/- 17.0% compared with the predrug value. We found that the best predictor of further exercise-induced QRS slowing was the change in QRS duration produced by flecainide at rest (r = 0.76, p = 0.001). In an age- and disease-matched control group, the QRS duration did not change during exercise that caused a similar heart rate increase.(ABSTRACT TRUNCATED AT 250 WORDS)
Improved Clinical Outcome in Indolent B-Cell Lymphoma Patients Vaccinated with Autologous Tumor Cells Experiencing Immunogenic Death
Authors: Roberta Zappasodi, Serenella M. Pupa, Gaia C. Ghedini, Italia Bongarzone, Michele Magni, Antonello D. Cabras, Mario P. Colombo, Carmelo Carlo-Stella, Alessandro M. Gianni, Massimo Di Nicola
Journal: Cancer Research (2010)

Abstract Increasing evidence argues that the success of an anticancer treatment may rely on immunoadjuvant side effects including the induction of immunogenic tumor cell death. Based on the assumption that this death mechanism is a similar prerequisite for the efficacy of an active immunotherapy using killed tumor cells, we examined a vaccination strategy using dendritic cells (DC) loaded with apoptotic and necrotic cell bodies derived from autologous tumors. Using this approach, clinical and immunologic responses were achieved in 6 of 18 patients with relapsed indolent non–Hodgkin's lymphoma (NHL). The present report illustrates an impaired ability of the neoplastic cells used to vaccinate nonresponders to undergo immunogenic death on exposure to a cell death protocol based on heat shock, γ-ray, and UVC ray. Interestingly, when compared with doxorubicin, this treatment increased surface translocation of calreticulin and cellular release of high-mobility group box 1 and ATP in histologically distinct NHL cell lines. In contrast, treated lymphoma cells from responders displayed higher amounts of calreticulin and heat shock protein 90 (HSP90) compared with those from nonresponders and boosted the production of specific antibodies when loaded into DCs for vaccination. Accordingly, the extent of calreticulin and HSP90 surface expression in the DC antigenic cargo was significantly associated with the clinical and immunologic responses achieved. Our results indicate that a positive clinical effect is obtained when immunogenically killed autologous neoplastic cells are used for the generation of a DC-based vaccine. Therapeutic improvements may thus be accomplished by circumventing the tumor-impaired ability to undergo immunogenic death and prime the antitumor immune response. Cancer Res; 70(22); 9062–72. ©2010 AACR.
Open access colonoscopy in the training setting: which factors affect patient satisfaction and pain?
Authors: A. Eckardt, C. Swales, K. Bhattacharya, W. Wassef, N. Phelan, S. Zubair, N. Martins, S. Patel, B. Moquin, N. Anwar, K. Leung, J. Levey
Journal: Endoscopy (2008)

See also: Commentaire de travail de A. J. Eckardt et al., pp. 98Endoscopy 2008; 40(02): 234-234DOI: 10.1055/s-0032-1306809
Youthful Turmoil--Transient or Permanent?
Authors: D. W. K. Kay
Journal: BMJ (1974)

Much psychiatric illness in adolescence is regarded as a transient phase of turmoil or crisis related to maturation, essentially a normal or even valuable experience.This book gives a trans-Atlantic perspective.Throughout, sociological factors are accorded a major role.Many of the authors are at pains to explain or defend, and some identify themselves with, the adolescent's counter-culture.An extreme example is the judgement that "the truly brilliant psychotics and criminals occupy high offices in govern- ment, in industry, and in the military," while most of those so-named are the victims of poverty, oppressive laws, and hypocritical values.A more moderate view
A NEW NON-INVASIVE METHOD FOR DETECTION OF LOCAL INFLAMMATION IN ATHEROSCLEROTIC PLAQUES: EXPERIMENTAL APPLICATION OF MICROWAVE RADIOMETRY
Authors: Konstantinos Toutouzas, Haralampos Grassos, Andreas Synetos, Maria Drakopoulou, Eleftherios Tsiamis, Carmen Moldovan, George Agrogiannis, Efstratios Patsouris, Elias Siores
Journal: Journal of the American College of Cardiology (2011)
Colonic secretory effect in response to enteral feeding in humans.
Authors: T E Bowling, A H Raimundo, G K Grimble, D B Silk
Journal: Gut (1994)

Diarrhoea complicating enteral feeding is a common clinical problem affecting up to 25% of patients. Its pathogenesis remains unknown. A new technique of human in vivo segmental colonic perfusion was used to investigate colonic water and electrolyte movement in response to enteral feeding. Four groups of studies were performed in which low and high load polymeric enteral diet infusions were undertaken, either intragastrically or intraduodenally (n = 6 each group). Net absorption of sodium, chloride, and water occurred during fasting throughout the colon in all groups. There was a significant net secretion of sodium, chloride, and water in the ascending colon during low load (sodium: -42 mmol/h; 95% confidence limits -52 to -19, Chloride: -18 mmol/h; -50 to +16, water: -174 ml/h; -348 to -30) and high load (sodium: -24 mmol/h; -60 to +8, chloride: -18 mmol/h; -31 to +16, water: -120 ml/h; -246 to +6) gastric feeding, and during high load duodenal feeding (sodium: -12 mmol/h; -22 to -6, chloride; -6 mmol/h; -16 to +3, water: -72 ml/h; -144 to -6). Net secretion persisted in the distal colon only during high load gastric feeding. In the other three groups there was a net absorption in the distal colon. This study identified a significant colonic secretory response to enteral feeding, which is related to the site and load of the diet infusion. This response may play an important part in the pathogenesis of enteral feeding related diarrhoea.
Anchors away: contribution of a glycolipid anchor to bacterial invasion of host cells
Authors: M. J. Baron
Journal: Journal of Clinical Investigation (2005)

Group B Streptococcus (GBS) is an important cause of infections, including meningitis. The molecular events underlying its pathogenesis are poorly understood. A study in this issue of the JCI reports that the GBS invasion-associated gene (iagA) contributes to meningeal infection and virulence by facilitating invasion of the cells that compose the blood-brain barrier and of other host cells. The mechanism involved most likely relates to the gene product’s role in synthesis of a glycolipid anchor for a bacterial cell-surface entity that interacts directly with host cells.
New Science Aimed at an Ancient Killer
Authors: Anthony S. Fauci
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
How much are doctors worth: how much do doctors really earn?
Authors: Richard Rosin
Journal: BMJ (2007)

Until 2004, general practitioners were responsible for the care of their registered patients 24 hours a day and seven days a week.They did not have to provide that care themselves but remained responsible for arranging and coordinating it.As a result of the new GP contract, most general practitioners have now opted out of this responsibility and are contracted to work for the NHS from 8 am to 6 30 pm and for only five days a week.
SUDDEN DEATHS AFTER USE OF MERCURIAL DIURETICS
Authors: Harold Thomas Hyman
Journal: JAMA (1942)

<h3>To the Editor:—</h3> In the July 25 issue ofThe Journalappear a series of careful reports and an enlightening editorial relative to the sudden deaths following the intravenous administration of mercurial diuretics. Since my work on "speed shock" and the slow intravenous drip, in 1931, I have been intensely interested in the problem of reactions and I ask your leave to comment on the present situation. I do not think it is sufficiently stressed that these fatalities resulted from a technical cause rather than from the drug itself. This conclusion is borne out by several considerations: 1. Death occurred mostly, if not exclusively, from intravenous injection. 2. Death or the fatal reaction occurred usually within a few minutes after the injection, so that the accident could not have been due to a specific pharmacodynamic action of the molecule itself. 3. So many of the patients had had previous injections