tbuckley/cabot-search huggingface dataset:
The Effect of a Medicated Wash on Acne
Authors: F. Ray Bettley
Journal: British Journal of Dermatology (1972)

Journal Article The Effect of a Medicated Wash on Acne Get access F. Ray Bettley F. Ray Bettley The Middlesex Hospital, London, W.l Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 87, Issue 3, 1 September 1972, Pages 292–293, https://doi.org/10.1111/j.1365-2133.1972.tb00327.x Published: 01 September 1972
GENERALS WOOD AND PERSHING
Authors: James A. Brussel
Journal: JAMA (1960)

To the Editor:—  Dr. James A. Tobey, in The Physician Who Was Nominated for President, inThe Journal, May 21, page 296, omitted one unusual feature in his biography of Leonard Wood. In 1923 General Wood was appointed provost of the University of Pennsylvania, a post he held for one year, although he never appeared on or near the campus for one second during that time. Dr. Tobey evinces some surprise that Black Jack Pershing was promoted from captain to brigadier general over the heads of 862 officers who outranked him. It was perfectly simple. Captain Pershing had married the daughter of Senator Warren, who was the chairman of the Senate Armed Forces Committee.
Glucagon Responses to Hypoglycemia in Children and Adolescents With IDDM
Authors: Carol Singer-Granick, Robert P Hoffman, Kirk Kerensky, Allan L Drash, Dorothy J Becker
Journal: Diabetes Care (1988)

To investigate plasma glucagon counterregulatory responses to hypoglycemia, an intravenous insulin bolus was given over 2 min to 73 children, aged 8.5–18.8 yr, with diabetes duration 1.2–17.1 yr. The plasma glucagon responses of the 61 children without glucagon antibodies or abnormal glucagon molecules were compared with those of 13 nondiabetic control subjects, aged 8.3–18.3 yr. Glucagon increments from baseline (73 ± 10 pg/ml) and peak glucagon responses (212 ± 13 pg/ml) were markedly lower in diabetic patients than in control subjects (341 ± 49 and 462 ± 51 pg/ml, respectively, P &amp;lt; .001). Glucagon responses were found to correlate positively with the age of the patients at the time of testing (r = .478, P &amp;lt; .001) and inversely with metabolic control as measured by glycosylated hemoglobin (r = −.342, P &amp;lt; .02). There was no relationship between glucagon responses and diabetes duration. There was also no relationship between the glucagon increments and free-insulin levels during the test. Glucose recovery from the nadir was impaired in diabetic subjects compared with control subjects and correlated inversely with free-insulin levels. However, glucose recovery did not correlate with the rise of plasma glucagon. Glucose recovery was not different in patients with glucagon antibodies. In this study, we have demonstrated a deficient glucagon response to hypoglycemia in children with insulin-dependent diabetes mellitus. However, the clinical significance of this deficit is not clear.
How to Avoid Needle Stick Injury
Authors: William T. Merritt
Journal: JAMA (1988)

<h3>To the Editor.</h3> —Hepatitis B and the human immunodeficiency virus are both known to be transmitted by needle stick. In the operating room and in the intensive care setting, most blood specimens are drawn through an indwelling catheter into a syringe. Subsequently, the specimen is placed into vacuum tubes for laboratory testing. This requires removing the tube stopper and destroying the vacuum or the use of a needle to puncture the stopper. The former risks spillage of tube contents from loss of vacuum and the latter risks needle stick injury and is not recommended.<sup>1</sup> A male multisample Luer adapter (Venoject, Terumo Medical Branch, Elkton, Md; Vacutainer, Division of B-D, Rutherford, NJ) modifies the vacuum system and allows the filling of vacuum tubes from syringes through a female-female adapter (Cobe Laboratories, Lakewood, Colo; First Medical Supply, Baltimore). In addition, if conditions permit, the male multisample Luer adapter will allow filling
Non-Hodgkin's Lymphoma for the Nononcologist
Authors: William N. Hait
Journal: JAMA (1985)

RECENT advances in the understanding of immunology have led to more precise classification of the non-Hodgkin's lymphomas (NHLs).<sup>1</sup>However, this precision has left the internist faced with a bewildering variety of classification schemes that may have engendered as much confusion as clarification. In this review we have attempted to present the development of current nosology in a manner that will help incorporate recent classifications into daily use. The early classification of lymphomas into giant-follicle lymphoma, lymphosarcoma, and reticulum cell sarcoma<sup>2</sup>did not accurately describe the wide variation in histological and clinical manifestations of the lymphoproliferative diseases. Therefore, there was a need for a better scheme of classification. <h3>CLASSIFICATION ACCORDING TO HISTOLOGY</h3> A major advance in the classification of lymphomas was proposed by Rappaport and co-workers in 1956<sup>1</sup>(Table 1). This scheme divided NHLs based on the architectural characteristics of the lymph node and the cytological characteristics of the
Ureteral Complications and Alterations of Ureteral Tonus in Regional Ileitis
Authors: Milton H. Redish
Journal: New England Journal of Medicine (1952)

THE occurrence of extravesical urinary-tract complications of regional ileitis has not been adequately appreciated by urologists and gastroenterologists. It is the purpose of this report to call attention to these diagnostic possibilities and to illustrate with several cases the clinical and roentgenographic pictures that may be due to the secondary retroperitoneal spread of the inflammatory process.Of specific interest is the fact that the presenting complaints may be almost entirely urinary whereas the gastrointestinal symptoms are minimal. This was true of the first reported case.1 On the other hand, the urinary-tract complication may be completely asymptomatic and may be detected . . .
HUMAN TUMOR XENOGRAFT IMAGING WITH MONOCLONAL ANTIBODIES
Authors: Barry D. Mann, Marvin B. Cohen, Romaine E. Saxton, Leonard Spolter, L. Stephen, Graha M. William, F. Benedict, Donald L. Morton, Martyn W. Burk
Journal: Clinical Nuclear Medicine (1982)

Mann, Barry D.; Cohen, Marvin B.; Saxton, Romaine E.; Spolter, Leonard; Stephen, L.; William, Graha M.; Benedict, F.; Morton, Donald L.; Burk, Martyn W. Author Information
Myocardial Imaging With I-123 MIBG and TI-201 Demonstrates Denervated But Viable Myocardium in a Patient With Myocarditis
Authors: TOSHIBUMI KINOSHITA, HISAO ITOH, KAZUHIKO TAKAHASHI, HISANAO TAKEDA
Journal: Clinical Nuclear Medicine (1994)

The authors present a case of myocarditis. Myocardial scintigraphic studies with I-123 MIBG and TI-201 were performed in the convalescent phase. I-123 MIBG myocardial imaging demonstrated prominent defects in the anterior wall and septum. The authors assume that there is denervated but viable myocardium after an episode of myocarditis.
Investigation, Treatment and Monitoring of Late-Onset Hypogonadism in Males
Authors: E. Nieschlag, R. Swerdloff, H.M. Behre, L.J. Gooren, J.M. Kaufman, J.-J. Legros, B. Lunenfeld, J.E. Morley, C. Schulman, C. Wang, W. Weidner, F.C.W. Wu
Journal: European Urology (2005)
Memory Impairments Associated With Postprandial Hyperglycemia and Glycemic Control
Authors: Carol E. Greenwood, Randall J. Kaplan, Stacey Hebblethwaite, David J.A. Jenkins
Journal: Diabetes Care (2004)

We thank Kubiak et al. (1) for their thoughtful appraisal of our study relating to memory response in adults with type 2 diabetes following carbohydrate ingestion (2). We agree entirely with their comment that the underlying origins of memory impairment in this population is poorly understood and that lack of consensus on standardized neuropsychologic testing procedures may, in part, be contributing to this confusion (3). Clearly, as Kubiak et al. point out, a major contributor to the variance in cognitive performance observed in this population is the high prevalence of other risk factors for cognitive decline, including cardiovascular disease, hypertension, and depression (4,5), making it challenging to isolate the potential contribution of diabetes per se.

We sought to explore cognitive function in adults with type 2 diabetes by perturbing the system through the administration of glucose, which is a treatment commonly used in studies of cognitive aging to explore the system’s plasticity in the face of underlying age-related deficits (6,7). A major advantage of applying this approach to the type 2 diabetic population is that changes observed in response to the challenge were unlikely to be directly attributable to vascular complications. Our data provided evidence for cognitive deficits, primarily related to declarative memory function, following the ingestion of 50 g of glucose in the form of …
Elevated plasma levels of fibrinopeptide a during sickle cell anemia pain crisis–evidence for intravascular coagulation
Authors: David A. Leichtman, George J. Brewer
Journal: American Journal of Hematology (1978)

Abstract A role for coagulation in the pathogenesis of sickle cell anemia (SCA) pain crisis has long been suspected. We have observed evidence for in vivo coagulation in patients with SCA during pain crisis utilizing a radioimmunoassay for fibrinopeptide A (FPA). Since the proteolytic activity of thrombin results in the release of FPA from fibrinogen, plasma levels of FPA may be used as an index of in vivo thrombin activity. In 20 normal controls FPA plasma levels had a range of 0.6–1.4 ng/ml and a mean of 0.7 ± 0.2 ng/ml. We observed elevations of FPA, values greater than the mean plus 4 standard deviations of the control group, in 21 consecutive plasma samples obtained from 8 SCA patients during pain crisis. FPA determinations on 7 of 10 plasma specimens obtained from 10 SCA patients during pain‐free periods were within the normal range. Elevations of FPA in 2 of 3 of these pain‐free patients could be explained by recent extensive oral surgery and faulty venopuncture, conditions known to cause elevated levels of the peptide. Plasma specimens were obtained from 2 SCA patients patients with subjective complaints of pain, but who were suspected of malingering prior to FPA determination. In both instances, FPA was within the normal range. In summary, plasma levels of FPA appear to be elevated in SCA patients during crisis as contrasted to pain‐free periods and normal controls. This study provides new evidence for the occurrence of intravascular coagulation during SCA pain crisis. Further studies are needed to assess whether this activation of the coagulation system is a cause or an effect of pain crisis.
Evaluation of a simplified oscillation technique for assessing airway obstruction in sleep apnoea
Authors: R. Farré, J. Rigau, J.M. Montserrat, E. Ballester, D. Navajas
Journal: European Respiratory Journal (2001)

The forced oscillation technique (FOT) is a noninvasive method that is useful for assessing airway obstruction and for titrating continuous positive airway pressure (CPAP) in patients with sleep apnoea. The aim was to evaluate the routine applicability of a simplified FOT set-up based on recording pressure and flow at the level of the CPAP device, i.e. obviating the need for connecting the transducers to the nasal mask. A correction to account for the tubing and the exhaust port was applied. This simplified FOT was evaluated on nine patients with moderate or severe sleep apnoea during routine CPAP titration. Patient impedance measured by the simplified FOT (| Z |) was compared with actual patient impedance (| Z rs |) measured simultaneously with a reference FOT based on recording pressure and flow at the nasal mask. An excellent agreement was found between | Z | and | Z rs | over the wide range of airway obstruction explored (4.8–72.1 cmH 2 O·s·L −1 ): | Z |=| Z rs |×0.86+1.3 cmH 2 O·s·L −1 (r= 0.99). Moreover, the simplified and the conventional FOT settings detected the same respiratory events during sleep. These results demonstrate that this simplified FOT is applicable for measuring airway obstruction during routine sleep studies in patients with sleep apnoea.
Cryptococcosis and Cushing's Syndrome
Authors: JOSEPH D. SAPIRA
Journal: Annals of Internal Medicine (1977)

Letters and Corrections1 November 1977Cryptococcosis and Cushing's SyndromeJOSEPH D. SAPIRA, M.D.JOSEPH D. SAPIRA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-5-634_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Regarding the article by Drs. Ferguson and Smith, "Cryptococcosis and Cushing's Syndrome" (Ann Intern Med87:65-66, 1977), I believe that the first report in the English language since 1950 of cryptococcosis in the presence of Cushing's syndrome secondary to endogenous steroid excess was by Dyson in TheNew England Journal of Medicine261:169, 1959. Does it matter who is first?... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOSEPH D. SAPIRA, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe value of reporting cases 1 November 1977Volume 87, Issue 5Page: 634-634KeywordsCryptococcosis ePublished: 1 December 2008 Issue Published: 1 November 1977 PDF downloadLoading ...
Mesozoic mammals and early mammalian brain diversity
Authors: Emmanuel Gilissen, Thierry Smith
Journal: Behavioral and Brain Sciences (2003)

Fossil remains witness the relationship between the appearance of the middle ear and the expansion of the brain in early mammals. Nevertheless, the lack of detachment of ear ossicles in the mammaliaform Morganucodon, despite brain enlargement, points to other factors that triggered brain expansion in early mammals. Moreover, brain expansion in some early mammalian groups seems to have favored brain regions other than the cortex.
THE RINGWORM QUESTION IN ELEMENTARY SCHOOLS
Authors: P. S. Abraham
Journal: BMJ (1907)

BILE DUCTS. TBaf Post-mortem Examination.-Bodywell developed, but markedly wasted.No signs of congenital syphilis.No enlargement of glands, no haemorrhages, no oedeme.Marked jaundice of entire skin, CODnanotivae, and all 'the internal organs.The pericardium was healthy.The heart weighed oz and was healthy.Tne pleurae were healthy.Each lung weighed 2i oz., and exhibited small areas of collapse along the poiterior surface, but otherwise was orepitant throughout No ascites no peritonitis, no enlargement of mesenteric glands, but a few enlarged dark coloured glands at the hilum of the liver.The stomach and intestines presented nothing abnormal.The spleen weighed 1 oz, was firm and enlarged.The kidneys each weighed toz, and with the supra- renals appeared normal.The uretars, bladder, uterus, and appendages were healthy.The pancreas appeared small, somewhat shriveUed, and tough.rhe liver weighed 7 oz.It was dark olive-green In colour, and its surface was roughly
Effect on cortical and trabecular bone mass of different anti-inflammatory treatments in preadolescent children with chronic asthma.
Authors: L C Martinati, F Bertoldo, E Gasperi, S Micelli, A L Boner
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Bone metabolism and density have been shown to be abnormal in adult asthmatic patients treated with inhaled corticosteroids. Because the largest increases in bone growth and mineral deposition occur during childhood and adolescence, we performed a cross-sectional evaluation of cortical and trabecular bone mass by dual-photon absorptiometry at the proximal one third of the radius (cortical bone) and by dual-energy X-ray absorptiometry at the L2-L4 lumbar spine (trabecular bone) in 64 prepubertal asthmatic children receiving beclomethasone dipropionate (BDP) or cromolyn sodium (CS). Dual-energy X-ray absorptiometry was performed by anteroposterior scan and also by lateral vertebral scan in order to exclude the posterior elements of the vertebrae, which are composed mainly of cortical bone and which are less sensitive to the negative effect of steroids. Furthermore, we calculated "volumetric" bone density, dividing lateral mineral content by the vertebral volume. Bone mineral areal density and volume bone density did not differ in children receiving BDP for 6.7 +/- 1.3 mo at a mean dose of 319.3 +/- 130 micrograms/d compared with those in children treated with CS. Furthermore, anteroposterior bone density in our study population was in agreement with published normative data and with that of normal age-related healthy nonasthmatic children living in the same area and with the same dietary intake of calcium. No normal values are available for lateral and calculated-volume bone density. In conclusion, treatment with BDP does not appear to have an adverse effect on bone mass in prepubertal children with mild moderate asthma. Longitudinal studies should be performed in order to evaluate the effect of early introduction of inhaled corticosteroids in children with mild asthma.
Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma
Authors: Naoya Mimura, Mariateresa Fulciniti, Gullu Gorgun, Yu-Tzu Tai, Diana Cirstea, Loredana Santo, Yiguo Hu, Claire Fabre, Jiro Minami, Hiroto Ohguchi, Tanyel Kiziltepe, Hiroshi Ikeda, Yutaka Kawano, Maureen French, Martina Blumenthal, Victor Tam, Nathalie L. Kertesz, Uriel M. Malyankar, Mark Hokenson, Tuan Pham, Qingping Zeng, John B. Patterson, Paul G. Richardson, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood (2012)
GABA immunoreactivity and 3H-GABA uptake in mucosal epithelial cells of the rat stomach.
Authors: K R Jessen, J M Hills, A R Limbrick
Journal: Gut (1988)

GABA, best known as a neurotransmitter in the central nervous system, is also present in various peripheral tissues including the gastrointestinal tract, where there is strong evidence that GABA acts as a transmitter in some intrinsic myenteric neurones. Several studies indicate that the gastric mucosa is one of the sites of action of GABA in the gut. Highly specific anti-GABA antibodies have been used to detect endogenous GABA in the mucosa of the rat gastrointestinal tract, and 3H-GABA uptake followed by autoradiography has been used to localise cells with uptake sites for exogenous GABA. It was found that although GABA immunoreactive nerve fibres are essentially absent from this site, some mucosal cells are strongly GABA-immunoreactive. These cells are common in the pyloric stomach and upper part of the small intestine. The autoradiographic experiments provide evidence that these cells also possess high-affinity GABA uptake sites. These observations raise the possibility that in the gastrointestinal tract GABA acts as a gut hormone in a subpopulation of mucosal endocrine cells, in addition to its role as an enteric neurotransmitter.
Acute Purulent Exacerbation of Chronic Obstructive Pulmonary Disease and<i>Chlamydia pneumoniae</i>Infection
Authors: NESRIN MOGULKOC, SAIT KARAKURT, BARBARA ISALSKA, ÜLKÜ BAYINDIR, TURGAY ÇELIKEL, VOLKAN KORTEN, NESRIN ÇOLPAN
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

In order to investigate the role of bacteria, including Mycoplasma pneumoniae and especially Chlamydia pneumoniae in acute purulent exacerbations of chronic obstructive pulmonary disease (COPD), we examined sputum specimens and acute and convalescent sera taken 26 d apart from 49 outpatients experiencing an acute purulent exacerbation of COPD. The sera were tested for antibodies to C. pneumoniae with the microimmunofluorescence test, and for antibodies to M. pneumoniae with the indirect fluorescence antibody test. Routine microbiologic culture of sputum yielded potentially pathogenic microorganisms in 12 of the 49 patients (24%). Three patients (6%) showed serologic evidence of recent M. pneumoniae infection. Seven patients showed high IgG titers of >/= 1:1,024 to C. pneumoniae, and an additional four had a fourfold increase in IgG titer, suggesting reinfection with C. pneumoniae. Sputum from two of these 11 patients also grew Streptococcus pneumoniae, and one grew Moraxella catarrhalis. Patients with and without serologic evidence of current C. pneumoniae infection showed no significant differences in clinical features or pulmonary function. The high incidence of infection with C. pneumoniae (the sole causal agent in 16% of cases, and the causal agent with other agents in 6%) provides insight into the importance of this organism among agents leading to exacerbations of COPD in Turkey.
Abstract B44: Combination treatments of SCLC with ABT-263 and Immunotoxins produces synergistic killing of ABT-263-resistant cells
Authors: Abid R. Mattoo, David J. Fitzgerald
Journal: Clinical Cancer Research (2012)

Abstract Small cell lung cancer (SCLC) cell lines are variably sensitive to the BH-3 only peptide mimetic, ABT-263. To determine their sensitivity to toxin-based reagents, we incubated four representative SCLC lines with a model Pseudomonas exotoxin-based immunotoxin directed to the transferrin receptor. Remarkably in 4-of-4 lines, there was little evidence of immunotoxin-mediated cytotoxicity despite near complete inhibition of protein synthesis. However, when combinations of ABT-263 and immunotoxin were added to the ABT-263-resistant cell lines (H196 and H69AR), there was synergistic killing as evidenced by increased activation of caspase 3/7, annexin V staining and loss of cell integrity. This synergy was also noted when the closely related compound ABT-737 was combined with the same immunotoxin. To establish that the synergy seen in tissue culture could also be achieved in vivo, H69AR cells were grown as tumors in nude mice and shown to be susceptible to the killing action of an immunotoxin-ABT combination but not to either agent alone. When immunotoxin-ABT combinations were added to ABT-263-sensitive lines (H146 and H889), killing was primarily due to the action of ABT-263. Our data support combination approaches for treating ABT-263-resistant SCLC with ABT-263 and a second agent that provides synergistic killing action.
A Case of Traumatic Cerebral Abscess: Trephining: Free: Discharge of Cerebro-Spinal Fluid: Recovery
Authors: F. A. Southam
Journal: BMJ (1891)

birth of her last child, she began to grow stout.She has been under my observation for the last twelve years, during which time the disease in the leg has developed, and steadily in- creased.When first seen in 1879 the left leg was slightly larger than the right, but there existed at that time no indication of the elephantiasis.The patient states she had white swelling of the leg affected after her tenth confinement twenty- three years ago; slhe was confined to the house for three months from this cause.What relation there was between this illness and the present condition I am not prepared to state; the interval between the confinement referred to and the onset of the present condition, about twelve years, does not favour the connection.The present condition began with slight constitutional disturbance; enlargement of the foot and leg became general; some patches of eczema were trouble- some for several years, the leg gradually taking on the appearance it now presents.This is well shown in the accompanying illustration.The following are the dimensions of the legs in circum- ference:4 inches below knee, sound leg, 16 inches; left leg, 27 inches M\liddle of calf ... ,