tbuckley/cabot-search huggingface dataset:
Systemic mastocytosis with associated clonal hematological non‐mast‐cell lineage disease: Analysis of clinicopathologic features and activating <i>c‐kit</i> mutations
Authors: Vinod A. Pullarkat, Carlos Bueso‐Ramos, Raymond Lai, Steven Kroft, Carla S. Wilson, Sheeja T. Pullarkat, Xiangdong Bu, Maung Thein, M. Lee, Russell K. Brynes
Journal: American Journal of Hematology (2003)

The majority of patients with systemic mastocytosis with associated clonal, hematological non-mast cell lineage disease (SM-AHNMD) have a myeloid stem cell malignancy including myelodysplastic syndromes (MDS), myelodysplastic/myeloproliferative disorders, acute myeloid leukemia (AML), or chronic myeloproliferative disease. The clinicopathologic features of SM-AHNMD have not been fully characterized. We describe seven cases of this entity: 3 with MDS, 3 with AML, and 1 with chronic myelomonocytic leukemia. In the majority of cases, SM was diagnosed concurrently with the myeloid malignancy and aberrant mast cell morphology was observed. The commonly described c-kit enzymatic site mutation Asp816Val was detected only in 2 cases, while 3 patients carried the Asp816His mutation. Among the 3 cases with AML, 2 patients carried the translocation t(8;21). On the basis of our results and other reported cases, there appears to be a specific association between SM and AML with t(8;21). Concurrent occurrence of SM may define a subset of patients with de novo AML and other myeloid malignancies who have an adverse prognosis. As clinically effective tyrosine kinase inhibitors that inhibit enzymatic-type c-kit mutations are being developed, detection of mast cell proliferation associated with myeloid malignancy may have important therapeutic implications.
HLA-DQB1*02–Restricted HPV-16 E7 Peptide–Specific CD4+ T-Cell Immune Responses Correlate with Regression of HPV-16–Associated High-Grade Squamous Intraepithelial Lesions
Authors: Shiwen Peng, Cornelia Trimble, Lee Wu, Drew Pardoll, Richard Roden, Chien-Fu Hung, T.-C. Wu
Journal: Clinical Cancer Research (2007)

Abstract Purpose: The fact that up to 30% of established high-grade squamous intraepithelial lesions (HSIL) of the cervix regress spontaneously presents the opportunity to identify clinically relevant human papillomavirus (HPV) viral epitopes associated with disease outcome. Two human HPV antigens, E6 and E7, are functionally required for initiation and maintenance of cervical cancer precursor lesions and invasive cervical cancer. The identification and characterization of endogenously processed HPV antigenic epitopes in closely characterized patient cohorts will provide insight into the reasons for success or failure of therapeutic approaches. Experimental Design: We characterized the HPV-16 E6/E7–specific T-cell epitopes using E6/E7 overlapping peptide pools with peripheral blood lymphocytes obtained from normal healthy donors. We then analyzed the difference in the HPV-16 T-cell immune responses in HPV-16+ HSIL patients with or without spontaneous regression of lesions using the statistical methods. Results: We have identified an HPV-16 E7–specific CD4+ T-cell epitope [amino acids (aa) 71-85] that was restricted by HLA-DQB1*0201. Analysis of peripheral blood lymphocytes obtained from 14 HLA-DQB1*02 patients with HPV-16+ HSILs showed that the HPV-16+ E7 peptide (aa 71-85)–specific CD4+ T-cell immune response was significantly higher in the group of patients with regression compared with the patients without regression (P value &amp;lt;0.05). Conclusions: The HPV-16 E7 peptide–specific CD4+ T-cell immune response correlates with spontaneous regression of established HPV16+ HSILs. Thus, this E7 epitope may be useful for the characterization of HPV-specific immune responses in patients infected with HPV-16 or immunized with HPV vaccines.
Introspective Excursion of a Hypertensive Patient
Authors: M. van Loggem
Journal: Psychotherapy and Psychosomatics (1969)

Research Articles| February 12 2010 Introspective Excursion of a Hypertensive Patient Subject Area: Psychiatry and Psychology M. van Loggem M. van Loggem Amsterdam Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1969) 17 (3-4): 201–206. https://doi.org/10.1159/000286038 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation M. van Loggem; Introspective Excursion of a Hypertensive Patient. Psychother Psychosom 31 December 1969; 17 (3-4): 201–206. https://doi.org/10.1159/000286038 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1969Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Susceptibility of malignant plasma cells to HA-1H specific lysis suggests a role for the minor histocompatibility antigen HA-1 in the graft-versus-myeloma effect
Authors: P A Holloway, N Kaldenhoven, M van Dijk, A C Bloem, W de Lau, R van der Zee, B Kircher-Eibl, T Mutis, H M Lokhorst
Journal: Leukemia (2004)
An HIV Cure
Authors: Anthony S. Fauci, Hilary D. Marston, Gregory K. Folkers
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
End of free access to database will shrink UK generated research, says expert
Authors: Z. Kmietowicz
Journal: BMJ (2011)

The end of an agreement that allowed UK researchers direct access to a database of anonymised patient records from general practices will have a detrimental effect on research generated in the United Kingdom, a primary care expert has said.

Azeem Majeed, professor of primary care and head of the department of primary care and public health at Imperial College London, told the BMJ that the licence agreement between the Medical Research Council and the general practice research database (GPRD), the world’s largest primary care database, was “very useful in allowing UK researchers to make greater use of the [database].” He described the end of the scheme as “disappointing.”

He added, “The UK has one of the highest uses of electronic patient records in primary care, and these records [have been a] great resource for biomedical …
Topical imiquimod and intralesional interleukin-2 increase activated lymphocytes and restore the Th1/Th2 balance in patients with metastatic melanoma
Authors: D.S. Green, A.G. Dalgleish, N. Belonwu, M.D. Fischer, M.D. Bodman-Smith
Journal: British Journal of Dermatology (2008)

Patients with metastatic skin disease in malignant melanoma are difficult to treat, with unresectable lesions proving the biggest challenge. We have recently published data showing a significant clinical response in patients with multiple in-transit melanoma metastases treated with a combination of topical imiquimod and intralesional interleukin (IL)-2. Here we report the results of immunological analysis with the aim of highlighting correlations with our clinical findings.To investigate the systemic effects of our localized combination treatment in patients with accessible metastases of melanoma, and to correlate this with their clinical responses.The peripheral blood mononuclear cells of patients were collected at various time points throughout the treatment. Using antibodies to T-cell subsets we measured the changes in cell populations, and along with polyclonal stimulation, changes in cytokine production from these cells over a treatment course.We report an increase in the mean CD4/CD8 ratio from 2.78 to 3.54 with treatment (P < 0.01), and a rise in the percentage of CD25+ cells in the CD4+ population from 14.52% to 38.56%. Furthermore, staining with activation and T-regulatory markers showed that the majority of this population is activated T cells. Cytokine analysis on polyclonally stimulated peripheral blood mononuclear cells showed an increase in the ability of cells to produce interferon (IFN)-gamma over the treatment course, with an initial rise in the IFN-gamma/IL-5 ratio in five of six patients.The results of this study provide evidence that, in the majority of patients with in-transit metastases of melanoma, therapy with a combination of topical imiquimod and intralesional IL-2 induces a systemic immunological effect by reversing some of changes noted in patients with malignant disease.
Current Trends in Research and Clinical Management of Diabetes
Authors: Daniel B. Stone
Journal: JAMA (1961)

The editors of the<i>Annals of the New York Academy of Sciences</i>do a fine job. This comprises 43 papers given at a meeting in April, 1959, and published five months later. Those responsible have produced a superior book, for which they and consulting editor Forsham deserve thanks and praise. Even the best of editors has not solved the problem of how to work with a sow's ear, of course, but most of the participants at this conference brought some silk along. The papers cover a wide field: clinical facts and figures; new work in physiology; the use of oral drugs. In this book a few of the papers excel, most are good, and only a few are mediocre. I enjoyed much of this book. Steinberg contributes a scholarly and critical review of the genetics of diabetes. Fajans and Conn summarize clearly their excellent work upon diagnosis. Despite Wilkerson's insistence
Impaired Glucose Tolerance, Hyperinsulinemia, and Hypertriglyceridemia in Australian Aborigines From the Desert
Authors: Kerin O'Dea, Kathy Traianedes, John L Hopper, Richard G Larkins
Journal: Diabetes Care (1988)

A cross section of adult full-blooded Aborigines from three small isolated communities in the desert region of northwest Australia was surveyed for diabetes, impaired glucose tolerance (IGT), insulin levels, and lipoprotein lipids. Sixty-three men and 86 women from a total adult population of 330 were tested. Of the people tested, 67.6% had normal glucose tolerance, 25% had IGT, and 7.4% had diabetes. Both diabetes and IGT were strongly age related. Fasting insulin levels and insulin responses to oral glucose (elevation above basal) were elevated. Although fasting insulin rose with age, insulin response did not rise after adjustment for body mass index (BMI). Plasma triglyceride levels were high, particularly in men &amp;gt;35 yr old (3.13 ± 0.32 mM), but cholesterol levels were not elevated. Multiple regression analysis of fasting glucose, 2-h glucose, plasma triglyceride, fasting insulin, and insulin response for the nondiabetic subjects revealed 7) BMI was an independent risk factor for elevated 2-h glucose levels in women but not in men and was strongly related to fasting insulin concentrations in both genders; 2) fasting insulin concentration was an independent risk factor for increases in fasting glucose, insulin response, and triglyceride levels; 3) insulin response was related to the 2-h glucose level; 4) fasting and 2-h glucose levels and fasting insulin and triglyceride concentrations all rose with age in both genders, with the rate of increase generally greater in men. The most striking difference between these desert Aborigines and previously studied coastal Aborigines from the same geographical region was the significantly higher insulin response. It is possible that the more severe hyperinsulinemia in the desert Aborigines may indicate a greater degree of susceptibility to type II diabetes than in the coastal Aborigines as the duration of urbanization increases.
T cells in ankylosing spondylitis.
Authors: D Sotnik
Journal: Annals of the Rheumatic Diseases (1979)

Origin of the diphtheroid bacteria, mycoplasmas, etc., reported in association with autoimmune conditions SIR, Those of your readers who saw my previous note (Bisset, 1977) on the isolation of a bacterium from the erythrocytes of normal and arthritic subjects may be interested to know how these very slow and lengthy cultural procedures progressed.The final figures gave 30% positive isolations from 200 persons, who were either healthy or suffering from conditions other than arthritis (Bisset and Bartlett, 1978).Early cultures (which in this case means those only a few weeks old) usually consisted of diphtheroid bacilli or the spheroplasts that are fre- quently described as mycoplasmas; the latter were often acid-fast or grew as small, acid-fast rods on subculture.All these forms have proved to be phases in the L-cycle of the sporing bacillus now referred to as BLE (Bacillus licheniformis var.endoparasiticus Benedek).Although the rate of reversion to the fully sporogenous, parent form is very low indeed, in primary cultures or subcultures on ordinary medium, further work in this laboratory shows that it can be greatly increased by the use of known L-form reversion stimulants, which serves to substantiate the relationship of the various phases one to another.These results seem clearly to indicate that most if not all the bacterial forms claimed to be associated with arthritis are forms of a hitherto almost unsuspected cryptoparasite or symbiont of the blood.This includes so-called mycoplasmas, and supporting evidence has recently been provided by Walker and RajBhandary (1978), who have shown by analysis of tRNA sequences, that classical mycoplasmas are related to bacteria of precisely this type.Mutually corroborative evidence from 2 such different sources is much more impressive than either one by itself.Such a conclusion does not by any means imply that these bacteria are disqualified from playing a role in arthritis or other, mainly autoimmune, conditions.They may act as an immunological irritant, and initiate the sort of interaction, proposed with great clarity of detail by Pease (1965), which seems to be in excellent accordance with the known facts.It is worth keeping a record that Dr Pease was also the first to suggest the true identity of the well-known diptheroid bacilli as they occur in arthritis (Pease, 1974).
Targeted and pH‐Responsive Delivery of Doxorubicin to Cancer Cells Using Multifunctional Dendrimer‐Modified Multi‐Walled Carbon Nanotubes
Authors: Shihui Wen, Hui Liu, Hongdong Cai, Mingwu Shen, Xiangyang Shi
Journal: Advanced Healthcare Materials (2013)

Abstract We report the use of multifunctional dendrimer‐modified multi‐walled carbon nanotubes (MWCNTs) for targeted and pH‐responsive delivery of doxorubicin (DOX) into cancer cells. In this study, amine‐terminated generation 5 poly(amidoamine) (PAMAM) dendrimers modified with fluorescein isothiocyanate (FI) and folic acid (FA) were covalently linked to acid‐treated MWCNTs, followed by acetylation of the remaining dendrimer terminal amines to neutralize the positive surface potential. The formed multifunctional MWCNTs (MWCNT/G5.NHAc‐FI‐FA) were characterized via different techniques. Then, the MWCNT/G5.NHAc‐FI‐FA was used to load DOX for targeted and pH‐responsive delivery to cancer cells overexpressing high‐affinity folic acid receptors (FAR). We showed that the MWCNT/G5.NHAc‐FI‐FA enabled a high drug payload and encapsulation efficiency both up to 97.8% and the formed DOX/MWCNT/G5.NHAc‐FI‐FA complexes displayed a pH‐responsive release property with fast DOX release under acidic environment and slow release at physiological pH conditions. Importantly, the DOX/MWCNT/G5.NHAc‐FI‐FA complexes displayed effective therapeutic efficacy, similar to that of free DOX, and were able to target to cancer cells overexpressing high‐affinity FAR and effectively inhibit the growth of the cancer cells. The synthesized multifunctional dendrimer‐modified MWCNTs may be used as a targeted and pH‐responsive delivery system for targeting therapy of different types of cancer cells.
Intrathecal Baclofen: Not All Spasticity Is Bad-Reply
Authors: Leland Albright
Journal: JAMA (1991)

<h3>In Reply.</h3> —We appreciate Young's interest in our article and agree with him that function may be lost if lower-extremity spasticity is completely eliminated, eg, by a selective posterior rhizotomy. However, few—if any—patients function optimally if their spasticity is left untreated. As we indicated in the "Comment" section, the continuous administration of intrathecal baclofen via a programmable subcutaneous pump allows the dose to be titrated and the effects to be modulated so that spasticity is diminished and function is either retained or improved.
Abstract 820: Somatic mutations to identify tumors for highly selective chemosensitization by Nrf2 depletion
Authors: Gerald Batist, JianHui Wu, Tahar Abdulkassim, Gabriel Bendavit, Mark Abramovitz
Journal: Cancer Research (2012)

Abstract Therapeutic resistance remains a critical challenge in cancer treatment. Effective chemosensitizers must target more than a single mechanism of resistance and must also selectively sensitize only tumor and not normal tissue. Nrf2 is a transcription factor that regulates a battery of cytoprotective genes, and is shown in multiple experimental systems to have a significant impact on sensitivity to cytotoxic treatments. Regulation of Nrf2 levels is largely post-translationally, as a result of its physical interaction with adapter protein Keap1, which targets it for proteosomal degradation. An increasing number of human tumors and cancer cell lines are found to have loss of function mutations in Keap1 that results in constitutively elevated Nrf2 and drug resistance. In such circumstances alternative pathways for Nrf2 degradation may predominate, including the PI3kinase pathway protein GSK-3β, which exports Nrf2 from the nucleus to the proteosome. When relatively common somatic mutations in the PI3kinase pathway result in phosphorylation of GSK-3β at Ser9, it is inactivated. However, the addition of a PI3kinase pathway inhibitors increases GSK-3β, depletes Nrf2 and significantly sensitizes these cells. We are further exploring mechanisms, and at the same time screening biobanks of various tumors to determine the incidence of somatic loss of function mutations in Keap1 and mutations in the Pi3K pathway that activate it. This would represent a molecular signature of tumors that would be highly selectively sensitized by this strategy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 820. doi:1538-7445.AM2012-820
The relative importance of the factors involved in the absorption of vitamin E in children
Authors: D. P. R. Muller, J. T. Harries, J. K. Lloyd
Journal: Gut (1974)

The vitamin E status and ease of repletion in groups of children with coeliac disease, intestinal lymphangiectasia, and abetalipoproteinaemia was studied and compared with earlier studies in cystic fibrosis and obstructive jaundice. Each group represents an experimental model in which one of the transport steps involved in the absorption of vitamin E is defective or absent and thus the relative importance of these factors could be determined. Chylomicron formation and an adequate intraluminal concentration of bile salts were found to be the most important factors for the efficient absorption of the vitamin. The results in the five groups of patients have therapeutic implications if it is considered desirable to correct vitamin E deficiency states.