tbuckley/cabot-search huggingface dataset:
Halothane in Balanced Anesthesia
Authors: Kathryn E. McGoldrick
Journal: JAMA (1980)

To the Editor.—  As an anesthesiologist, I found the response by Carl C. Hug, Jr, MD, PhD (242:1299, 1979), regarding the status of low-dose halothane as part of a balanced  to be interesting and comprehensive. However, the parenthetic allusion to  as maximum allowable  was disturbing. It should be noted that Eger 1 defines MAC as the minimum alveolar concentration of anesthetic at one atmosphere that produces immobility in 50 percent of those patients or animals exposed to a noxious stimulus.
THE LIMITATIONS OF TENOTOMY OF THE EYE MUSCLES.
Authors: HOWARD F. HANSELL
Journal: JAMA (1895)

If we assume parallelism of the visual lines to be the functional position of rest, maintained by unconscious innervation and divergence, the anatomic position of rest (Hansen-Grüt), orthophoria or equilibrium for far and near is a condition of adjustment or relatively equal tension or balance of nerve and muscular force, and is not in any sense a condition of repose or relaxation of the muscles as in sleep or in ether narcosis. <i>Heterophoria and Heterotropia</i>, tendencies to deviation or deviations, are the result of spasm or supranormal contraction of a muscle or set of muscles, or of weakness or insufficiency of their antagonists. In this paper I will consider, very briefly, the abnormal relations of the visual axes, non-paralytic in origin, and the operative methods which theory and practice seem to demand for their adjustment. <h3>1. Esotropia or Internal Strabismus.</h3> —Hypermetropia is the cause in 75 to 90 per cent.
Bilateral Ovarian Dermoid Cysts
Authors: R M Boulay, E Podczaski
Journal: New England Journal of Medicine (2001)

Figure 1. A 27-year-old nulligravid woman presented with pelvic pain. Pelvic examination showed bilateral cystic, mobile, adnexal masses measuring 8 by 8 cm. A computed tomographic scan of the pelvis revealed bilateral adnexal masses with discrete, dense calcifications suggestive of teeth (arrows). Bilateral ovarian cystectomy was performed, and histopathological analysis demonstrated mature cystic teratomas with teeth. Thereafter, the patient has remained asymptomatic and pelvic examinations have been normal.
Azathioprine plus prednisone in treatment of pemphigoid.
Authors: J L Burton, R R Harman, R D Peachey, R P Warin
Journal: BMJ (1978)

Twenty-five patients taking part in a controlled trial to compare azathioprine plus prednisone with prednisone alone in the treatment of pemphigoid were followed up for three years. Results showed that the addition of azathioprine 2.5 mg/kg body weight daily reduced the total maintenance dose of prednisone needed by about 45%, with no increase in serious side effects or mortality. The suggestion that azathioprine might increase the risk of disseminated malignancy in elderly patients was not supported. We conclude that in future trials the combination of azathioprine with prednisone should be used as the standard treatment for comparison.
Association of rheumatic fever with serum albumin concentration and body iron stores in Bangladeshi children: case-control study
Authors: M M. Zaman, N. Yoshiike, M. A. Rouf, S. Haque, A. H. Chowdhury, T. Nakayama, H. Tanaka
Journal: BMJ (1998)

Malnutrition in early life may cause metabolic1 and immune2 imbalance and consequently affect tissue reactivity of the child to group A β haemolytic streptococcal infection of the throat, leading to rheumatic fever.1 In developing countries protein and iron deficiencies during childhood are common and cause growth retardation,3 which is also found in rheumatic fever.4 Iron deficiency predisposes to repeated infections,3 which are necessary for a rheumatic attack. We examined whether rheumatic fever is associated with serum protein concentrations and body iron stores in Bangladeshi children.

View this table:

Mean (SD) concentrations of nutritional markers, with risk of rheumatic fever associated with one unit increase in their serum values



Recruitment of subjects and their socioeconomic background are described elsewhere.4 Briefly, 218 consecutive subjects aged 5 to 20 years who had a recent infection with group A β haemolytic streptococci were selected in the outpatient clinic of the National Centre for Control of Rheumatic Fever and Heart Diseases, Dhaka. Of them, 60 had rheumatic fever (as …
Twelve Thousand Years Ago
Authors: Cortney Davis
Journal: Annals of Internal Medicine (2002)

Ad Libitum15 January 2002Twelve Thousand Years AgoCortney DavisCortney DavisRedding, CT 06896-0678Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-2-200201150-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Twelve thousand years agoSanibel Island rose from the sea,a coral reef hidden, then revealed.Having breakfast on our rented verandahI watch the pale blue Gulf of Mexicodisappear into the pale blue skyas a mother walks her three year oldtoward the sand. When he complainsabout the rough path, she lifts himand his red bucket to her hip.In Pittsburgh, when my father was dying,I dripped morphine under his tongueevery hour, every half hour, every twenty minutes.Don't be afraid, the hospice nurse told me,to give whatever will carry him. Author, Article, and Disclosure InformationAffiliations: Redding, CT 06896-0678Corresponding Author: Cortney Davis, PO Box 678, Redding, CT 06896-0678. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 2002Volume 136, Issue 2Page: 152KeywordsComputed axial tomographyHipMorphineNursesTongue ePublished: 15 January 2002 Issue Published: 15 January 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Evaluating the Results of Short-Term Anxiety-Provoking Psychotherapy
Authors: Peter E. Sifneos
Journal: Psychotherapy and Psychosomatics (1975)

Research Articles| February 12 2010 Evaluating the Results of Short-Term Anxiety-Provoking Psychotherapy Subject Area: Psychiatry and Psychology Peter E. Sifneos Peter E. Sifneos Beth Israel Hospital, Boston, Mass. Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1975) 25 (1-6): 217–220. https://doi.org/10.1159/000286868 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Peter E. Sifneos; Evaluating the Results of Short-Term Anxiety-Provoking Psychotherapy. Psychother Psychosom 31 December 1975; 25 (1-6): 217–220. https://doi.org/10.1159/000286868 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1975Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Specificity of the hepatocyte Na+ -dependent taurocholate transporter: Influence of side chain length and charge
Authors: William G. M. Hardison, Victor L. Heasley, Dale F. Shellhamer
Journal: Hepatology (1991)

Trihydroxy bile acids with differing nonsterol chain length and charge were synthesized to define the effect of these parameters on the ability to competitively inhibit the Na(+)-dependent uptake of 14C taurocholate into isolated rat hepatocytes. Compounds with long side chains (greater than or equal to 0.8 nm) beyond carbon-17 of the sterol nucleus and carrying a negative charge or no charge were potent inhibitors. Introduction of a positive charge into the side chain weakened inhibition. When the length of the chain beyond carbon-17 fell below about 0.7 nm, charge still influenced inhibitory potency, but the effect was reversed and positively-charged chains yielded slightly greater inhibition than negatively-charged chains. From these results one may postulate a positively-charged cell surface domain extending outward from a point about 0.7 nm from the sterol nucleus receptor region. Up to about 0.7 nm from the sterol nucleus receptor region one might postulate a negative cell surface charge to account for the weaker inhibitory potency of compounds with short negatively-charged chains. Nonetheless, a short chain, regardless of charge, weakened inhibition, suggesting that a long negatively-charged side chain is necessary to orient the sterol moiety for optimal receptor fit. These data confirm that the Na(+)-dependent taurocholate transport site is sensitive to alterations of side chain charge and length and emphasize the importance of structure when designing bile acid analogs to probe taurocholate transport mechanisms.
TCT-475 Triple Antithrombotic Therapy versus Dual Antiplatelet Therapy in Patients with Atrial Fibrillation undergoing Drug-eluting Stent Implantation
Authors: Cheol Woong Yu, Dong Oh Kang, Jae Young Cho, Hyung Joon Joo, Je Sang Kim, Rak Kyong Choi, Hyun Jong Lee, Jin Sik Park, Jae Hyoung Park, Cheol Woong Yu, Soon Jun Hong, Do-Sun Lim
Journal: Journal of the American College of Cardiology (2014)
A new selection system to recruit general practice registrars: preliminary findings from a validation study
Authors: Fiona Patterson, Eamonn Ferguson, Tim Norfolk, Pat Lane
Journal: BMJ (2005)

The present study compared the selectivity of two homologous transport proteins, multidrug and toxin extruders 1 and 2-K (MATE1 and MATE2-K), and developed three-dimensional pharmacophores for inhibitory ligand interaction with human MATE1 (hMATE1). The human orthologs of MATE1 and MATE2-K were stably expressed in Chinese hamster ovary cells, and transport function was determined by measuring uptake of the prototypic organic cation (OC) substrate 1-methyl-4-phenylpyridinium (MPP). Both MATEs had similar apparent affinities for MPP, with <i>K</i><sub>tapp</sub> values of 4.4 and 3.7 μM for MATE1 and MATE2-K, respectively. Selectivity was assessed for both transporters from IC<sub>50</sub> values for 59 structurally diverse compounds. Whereas the two transporters discriminated markedly between a few of the test compounds, the IC<sub>50</sub> values for MATE1 and MATE2-K were within a factor of 3 for most of them. For hMATE1 there was little or no correlation between IC<sub>50</sub> values and the individual molecular descriptors LogP, total polar surface area, or p<i>K</i><sub>a</sub>. The IC<sub>50</sub> values were used to generate a common-features pharmacophore, quantitative pharmacophores for hMATE1, and a Bayesian model suggesting molecular features favoring and not favoring the interaction of ligands with hMATE1. The models identified hydrophobic regions, hydrogen bond donor and hydrogen bond acceptor sites, and an ionizable (cationic) feature as key determinants for ligand binding to MATE1. In summary, using a combined in vitro and computational approach, MATE1 and MATE2-K were found to have markedly overlapping selectivities for a broad range of cationic compounds, including representatives from seven novel drug classes of Food and Drug Administration-approved drugs.
TCT-343 IFR PLUS INTRACORONARY NITROGLYCERINE: A NEW PHYSIOLOGICAL INDEX OF LESION SEVERITY
Authors: Javier Cuesta, Fernando Rivero-Crespo, Teresa Bastante-Valiente, Amparo Benedicto, Guillermo Diego-Nieto, Jorge-Andrés Restrepo, Fernando Alfonso
Journal: Journal of the American College of Cardiology (2014)
Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL
Authors: Albert K. Groen, Vincent W. Bloks, Robert H.J. Bandsma, Roelof Ottenhoff, Giovanna Chimini, Folkert Kuipers
Journal: Journal of Clinical Investigation (2001)

The ABC transporter ABCA1 regulates HDL levels and is considered to control the first step of reverse cholesterol transport from the periphery to the liver. To test this concept, we studied the effect of ABCA1 deficiency on hepatic metabolism and hepatobiliary flux of cholesterol in mice. Hepatic lipid contents and biliary secretion rates were determined in Abca1–/–, Abca1+/–, and Abca1+/+ mice with a DBA background that were fed either standard chow or a high-fat, high-cholesterol diet. Hepatic cholesterol and phospholipid contents in Abca1–/– mice were indistinguishable from those in Abca1+/– and Abca1+/+ mice on both diets. In spite of the absence of HDL, biliary secretion rates of cholesterol, bile salts, and phospholipid were unimpaired in Abca1–/– mice. Neither the hepatic expression levels of genes controlling key steps in cholesterol metabolism nor the contribution of de novo synthesis to biliary cholesterol and bile salts were affected by Abca genotype. Finally, fecal excretion of neutral and acidic sterols was similar in all groups. We conclude that plasma HDL levels and ABCA1 activity do not control net cholesterol transport from the periphery via the liver into the bile, indicating that the importance of HDL in reverse cholesterol transport requires re-evaluation.
Percutaneous coronary excimer laser angioplasty in patients with stable and unstable angina pectoris. Acute results and incidence of restenosis during 6-month follow-up.
Authors: K R Karsch, K K Haase, W Voelker, A Baumbach, M Mauser, L Seipel
Journal: Circulation (1990)

A clinical study was conducted to evaluate the efficacy and safety of percutaneous coronary excimer laser angioplasty in 60 patients with coronary artery disease. Forty-nine patients had stable exertional angina, and 11 patients had unstable angina despite medical therapy. A novel 1.4-mm diameter catheter with 20 quartz fibers of 100-microns diameter each arranged concentrically around a central lumen suitable for a 0.014-in. flexible guide wire was coupled to an excimer laser. A commercial excimer laser emitting energy at a wavelength of 308 nm with a pulse duration of 60 nsec was used. The laser was operated at 20 Hz. Mean energy transmission was 30 +/- 5 mJ/mm2. In five of the 60 patients, laser angioplasty was not attempted. In 23 patients with laser ablation alone, percent stenosis decreased from 76 +/- 14% before to 27 +/- 17% after ablation and was 34 +/- 15% at the early follow-up angiogram. In 32 patients, additional balloon angioplasty was performed because of vessel closure after laser ablation in 11 and an insufficient qualitative result in 21 patients. Of the 11 patients with unstable angina, one patient died due to vessel closure 3 hours after intervention, and two patients developed a myocardial infarction. In 22 of 47 patients with late follow-up angiography, restenosis within the 6-month follow-up period occurred. Rate of restenosis was higher in patients treated with laser ablation and balloon angioplasty (16 of 28) than in patients treated with laser ablation alone (six of 19). These results suggest that coronary excimer laser angioplasty for ablation of obstructive lesions is feasible and safe in patients with stable angina. However, development of new catheter systems is necessary for an improved success rate.
Lucent Lesion in the Femoral Neck
Authors: Joseph T. Ferrucci
Journal: JAMA (1967)

Dr. Joseph T. Ferrucci, Jr.: This patient, a 30-year-old surgeon, noted the sudden onset of pain in his left hip while descending a staircase four months prior to admission. The pain persisted and was slightly aggravated by extremes of motion. Night pain occasionally occurred. A roentgenogram six weeks prior to this admission revealed a lesion in the left femoral neck. Aspirin was administered with considerable relief of symptoms. The physical examination and laboratory studies were not remarkable, and this examination of the hip was performed (Figure). <h3>Discussion</h3> Dr. Laurence L. Robbins: Dr. Dreyfuss, do you have any ideas about this? Dr. Jack R. Dreyfuss: There is an area of rarefaction in the intertrochanteric region somewhat nearer the lesser trochanter. There is no periosteal reaction or sclerosis, and I do not see any other lesions. Actually, this is a fairly large area of lucency, measuring over 4 cm in length. It
mTOR Inhibitor Treatment of Pancreatic Cancer in a Patient With Peutz-Jeghers Syndrome
Authors: Heinz-Josef Klümpen, Karla C.S. Queiroz, C. Arnold Spek, Carel J.M. van Noesel, Helmy C. Brink, Wendy W.J. de Leng, Roeland F. de Wilde, Elisabeth M.H. Mathus-Vliegen, G. Johan A. Offerhaus, Maarten A. Alleman, Anneke M. Westermann, Dirk J. Richel
Journal: Journal of Clinical Oncology (2010)

A A B C A B C Fig 3. Caspase-3 activity in polyps in response to treatment with everolimus.Polyps collected before and after treatment were immunohistochemically stained for cleaved caspase-3 (active capsase-3) and counterstained with hematoxylin (in blue).The red arrows point to some of the cleaved caspase-3 positive cells (in brown).(A) Polyp tissue collected before treatment.(B) Polyps obtained after 6 months.(C) Polyps obtained after 8 months.Original magnification, ϫ20
A bazaar of opinions mostly fit within picoeconomics
Authors: George Ainslie
Journal: Behavioral and Brain Sciences (2005)

The will has generated a wider range of opinions than most phenomena, lacking as it does both an animal model and consistent behavioral correlates. It has even been held not to exist. The commentators approached my intertemporal bargaining (picoeconomic) model from many angles. Doubts about the existence of the underlying phenomenon, hyperbolic discounting, were still raised by some, but other commentators added to the evidence for it, which I regard now as overwhelming. Where mechanisms of self-control were specified, I found it possible to place them within a picoeconomic framework.
Paradoxical Upregulation of Tumor Suppressor Protein p53 in Serum-Stimulated Vascular Smooth Muscle Cells
Authors: Zakar H. Mnjoyan, Ranjan Dutta, Di Zhang, Ba-Bie Teng, Ken Fujise
Journal: Circulation (2003)

The proliferative response of vascular smooth muscle cells (VSMCs) to various growth stimuli is critical for atherosclerosis and postangioplasty restenosis. Although tumor suppressor protein p53 plays a critical role in the elimination of cancerous cells, recent genetic studies have indicated that it also protects against atherosclerosis and restenosis.We examined the levels of p53 protein in normal VSMCs before and after serum stimulation. The p53 protein levels increased robustly on stimulation. Upregulated p53 protein was capable of binding to the p53 consensus sequence, as shown by electrophoretic mobility shift assay. In addition, p53 upregulation was associated with increases in the transcript and protein levels of p21WAF1/CIP1 and Bax, as shown by real-time reverse transcriptase-polymerase chain reaction and Western blot analysis, respectively. Furthermore, the upregulation of p21WAF1/CIP1 and Bax was followed by cell-cycle arrest and apoptosis induction, as shown by 5-bromo-2'-dUTP incorporation assay and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling staining, respectively. Finally, double-staining analyses showed that the majority of p53-expressing cells also expressed p21WAF1/CIP1 and Bax proteins.p53 protein expression in quiescent VSMCs is paradoxically increased by application of a growth stimulus. Through the mediation of p21WAF1/CIP1 and Bax, the induced p53 protein negatively regulates the growth of dividing VSMCs, thereby minimizing the inappropriate accumulation of VSMCs. Therefore, p53 may be a negative regulator of VSMC growth.
How do we monitor asthma control?
Authors: J. K. Sont
Journal: Allergy (1999)

The present consensus on asthma management includes avoidance of triggers, education, regular follow-up, and an action plan that relies on symptoms and lung function measurements for the monitoring of disease severity. Inclusion of objective measurements for monitoring seems to be important because patients and physicians may not always recognize asthma symptoms or their severity. However, the additional value of monitoring peak flow and symptoms in guiding asthma therapy has not been well established. Furthermore, it can be questioned whether a treatment strategy which is solely based on optimizing symptoms and lung function leads to optimal control of asthma in each individual patient, since airway hyperresponsiveness (AHR) and airways inflammation may persist. The chronicity of such abnormalities may lead to airways remodelling, thereby worsening the long-term outcome of asthma. It has been shown that AHR provides prognostic information on asthma control, because it can serve as a valuable noninvasive surrogate marker of airways inflammation when added to the guides of asthma therapy. A limited increase in dose of inhaled steroids, instead of applying an increased dose indiscriminately, can be successfully tailored to the needs of the individual patient based on the degree of AHR. Such a strategy leads to both a better clinical outcome and a better histologic outcome. The present worldwide effort is to find alternative markers of airways inflammation in asthma that can be easily implemented in routine practice. In the near future, longitudinal studies will determine which parameter is potentially most useful in guiding asthma management.
"Bute" in horse meat presents very low risk to health, says England's chief medical officer
Authors: J. Wise
Journal: BMJ (2013)

England’s chief medical officer has tried to reassure the public about the safety of horse meat by announcing that someone would need to eat over 500 pure horse meat burgers a day to get close to acquiring dangerous amounts of phenylbutazone.

Phenylbutazone, known as bute, is a commonly used drug in horses. The Food Standards Agency said on 14 February that it had checked the carcasses of 206 horses slaughtered in the United Kingdom between 30 January and 7 February 2012. Eight tested positive for phenylbutazone, and meat from six of them may have entered the food chain in France.

But the …