tbuckley/cabot-search huggingface dataset:
Primary Herpes Simplex Virus Infection of the Fingers
Authors: John R. Ward
Journal: JAMA (1961)

THE VIRUS of herpes simplex is among the commonest pathogens of man. It has been estimated that 90% of adults have neutralizing antibodies in their serum, indicating infection by this virus.<sup>1</sup>There are 2 major types of clinical herpetic disease, regardless of the site infected, recognized: (1) a primary infection occurring in patients without circulating antibodies and (2) recurrent attacks in persons with neutralizing antibodies. Like many infectious agents, herpes can occur in a myriad of clinical syndromes. Until the report by Stern and associates<sup>2</sup>it was not generally recognized that a primary herpetic infection can occur on the fingers of adults. It is likely that such infections are common, but are rarely recognized as being of viral etiology. Because of the paucity of reports in the American literature on primary herpes simplex infections of the fingers in adults, the following case is presented. A brief review
Constrictive Pericarditis Resulting from Dracunculosis
Authors: S. G. Kinare, G. B. Parulkar, P. K. Sen
Journal: BMJ (1962)

On inquiry from the patient and her relatives it was established that she was very fond of watercress, which she was wont to gather from roadside ditches near her house, having once been heard to complain that " the cows had eaten it all."A feature of the case was the entire absence of a history of the occurrence at any time of an acute febrile illness with " liver pain," such as is characteristic of the invasive (larval) stage of the disease.For this reason it is difficult to fix the time of infection, but the duration of the attacks of colic and the grossly pathological condi- tion of the bile-duct indicate that it was not later than 1959, and as that was a very dry year, unsuitable for the development of the fluke, 1958 seems the latest time -this was the year of the outbreak previously referred to.
A SIMPLE METHOD OF BLOOD TRANSFUSION IN INFANCY
Authors: G. H. Alabaster
Journal: BMJ (1925)

The majority of patients affected by chronic rhinosinusitis (CRS) suffer from eosinophilic infiltration. We hypothesised that polihexanide and polyethylene glycol as an antiseptic might alter the eosinophil-associated IL-5 and eotaxin-3 expression in CRS and also the expression of MMP-9, being involved in the tissue-remodelling in CRS. After obtaining samples from 10 CRS patients with (CRSwNP) and without nasal-polyposis (CRSsNP) and 2 patients with inverted-papilloma undergoing functional endoscopic sinus surgery (FESS), the expression of interleukin-5, eotaxin-3 and MMP-9 were evaluated by an ELISA assay with and without the tested agent. CRSwNP showed a significantly increased expression of IL-5. Polihexanide seems not to alter the attraction of eosinophils in patients with CRS via IL-5 expression. Also elevated levels of MMP-9 could not be reduced to normal values. But there exists statistically significant evidence that the self-amplification process of eosinophils via eotaxin-3 could be influenced by the administration of polihexanide.
The Relation of Cardiovascular Phenomena to Metabolic Changes in a Patient with Chronic Hypokalemia
Authors: EDWARD J. HUTH, RUSSELL D. SQUIRES
Journal: Circulation (1956)

Cardiovascular phenomena were studied and correlated with metabolic data in an adult male with chronic hypokalemia. The appearance and disappearance of postural hypotension, the changes in heart rate, the S-T segment shifts, and the U-wave amplitudes correlated well with the changing serum potassium level during experimental acute potassium depletion. QRS and T-wave changes could not be correlated with metabolic data. Comparison with the cardiovascular manifestations of experimental potassium depletion in normal subjects suggested that this patient had a chronic potassium depletion of at least 300 mEq.
A SEROLOGICAL STUDY OF THE POLYSACCHARIDES OF MENINGOCOCCUS, B. ANTHRACIS, B. PROTEUS, B. SUBTILIS AND B. MESENTERICUS
Authors: José Zozaya
Journal: The Journal of Experimental Medicine (1931)

1. The meningococcus polysaccharide reacts with a broad precipitable carbohydrate antibody in common with those of B. anthracis, B. subtilis, B. proteus and B. mesentericus. 2. The anthrax and proteus polysaccharides are specific in the higher dilutions of serum. 3. Antianthrax serum contains two different polysaccharide precipitable antibodies, one specific and the other non-specific. 4. Agglutinins have no relation to the carbohydrate precipitable substance, specific or non-specific. 5. An immunological method is given for the study of the probable chemical relation or similarity of polysaccharides of different bacteria similar to that given by Heidelberger, Goebel and Avery from a strain of Friedländer bacillus and Pneumococcus Type II.
PRODUCTION OF PERNICIOUS ANAEMIA (BARTONELLA ANAEMIA) IN RATS BY DEFICIENT FEEDING
Authors: L. Wills
Journal: BMJ (1930)

ALBINO RATS.IM TuC BRJTrsa 1167 Otlier factors than dysfunction or disease of uteruis andl ovaries are responsible for some cases of uterine bleeding.C(a-"ls occur in wlichl it is to be attributed to a pathological (lition of the blood.Trhe miiechanismii of haemorrhage in these cases is not clear, b)ust it may depend on disordered calciuml ml-etabolism-for example, increased calciutim obutpuit or low blood calcium.In cases of severe iiterine liaemorrhage withouit obvious pelvic or local cause, a systemic investigation and a detailed blood examination (preferably by a haematologist) sliould be iade at the earliest opportunity.I am indebted to the surgeons of tlhe Royal Samaritani Hospital for Womeni, Glasgow (Drs.Shannon, W'est, Gardner, aiid McTntyre), anid to the medical superinteindents of the Glasgow Royal anld Victoria Infirmaries (Drs.Grant and McCall Smith respectivcly), for access to records and notes in some of these cases.
A Modified Instrument for Thoracentesis, Paracentesis and Intravenous Fluid Therapy
Authors: M. Michael Eisenberg
Journal: New England Journal of Medicine (1963)

THE superiority of plastic catheters and cannulas over steel needles and trochars for intravenous use and for diagnostic and therapeutic body-cavity drainage appears well established. Although many have been demonstrated as adequate for the various procedures for which they are intended certain shortcomings have limited their usefulness and efficiency.1 2 3 4 5 In some cases the cannulas are introduced into the body cavity through steel trochars, thereby limiting the maximal diameter of the catheter to the internal diameter of the trochar. In others the cannulas are adapted to a steel hub requiring disassembly and reassembly for reuse. This has further disadvantages in the . . .
A SURVEY OF MENTAL DISEASE IN AN URBAN POPULATION VII. AN APPROACH TO TOTAL PREVALENCE BY RACE
Authors: BENJAMIN PASAMANICK
Journal: American Journal of Psychiatry (1962)

This paper reported the results of a series of concurrent investigations in Baltimore dealing with the prevalence rates for various psychiatric disorders in the white and nonwhite population. The findings based on a community survey, and state, private and V.A. hospital rates indicate that the white population has the higher rates for the psychoses, psychoneuroses, and the psychophysiologic-autonomic-visceral disorders. Nonwhite rates are higher for the acute brain syndromes and for mental deficiency. An attempt is made to explain these variations and to refute the conclusions of a previous study by Wilson and Lantz in Virginia.
FLT3 ligand and not TSLP is the key regulator of IL-7–independent B-1 and B-2 B lymphopoiesis
Authors: Christina T. Jensen, Shabnam Kharazi, Charlotta Böiers, Min Cheng, Anna Lübking, Ewa Sitnicka, Sten Eirik W. Jacobsen
Journal: Blood (2008)
Identification of patients with poorer survival in primary myelofibrosis based on the burden of JAK2V617F mutated allele
Authors: Paola Guglielmelli, Giovanni Barosi, Giorgina Specchia, Alessandro Rambaldi, Francesco Lo Coco, Elisabetta Antonioli, Lisa Pieri, Alessandro Pancrazzi, Vanessa Ponziani, Federica Delaini, Giovanni Longo, Emanuele Ammatuna, Vincenzo Liso, Alberto Bosi, Tiziano Barbui, Alessandro M. Vannucchi
Journal: Blood (2009)
Non-steroidal anti-inflammatory drugs and serious gastrointestinal adverse reactions.
Authors: E P Dewar, A J Walker
Journal: BMJ (1986)

with those in the white population from the same catchment area.'Results in Asian women are much poorer than those in white women.Their complaints are also less accessible, more complex, and apparently more affected by transcultural factors than those of their husbands.Bangladeshi women here are socially, linguistically, and culturally more isolated.Also their complaints did not affect fertility as directly as their partners': they were often a manifestation of marital or family strife.Modified Masters and Johnson sex therapy can achieve a good outcome with male sexual problems in Bangladeshi patients when both partners attend.Motivation is likely to be highest when fertility is directly affected.
Role of aquaporin-4 in the development of brain oedema in liver failure
Authors: Gavin Wright, Robin Soper, Heather F. Brooks, Vanessa Stadlbauer, Balasubramaniyan Vairappan, Nathan A. Davies, Fausto Andreola, Stephen Hodges, Raymond F. Moss, D. Ceri Davies, Rajiv Jalan
Journal: Journal of Hepatology (2010)
Isoniazid and Disseminated Intravascular Coagulation
Authors: JOHN J. STUART
Journal: Annals of Internal Medicine (1976)

Comments and Corrections1 April 1976Isoniazid and Disseminated Intravascular CoagulationJOHN J. STUART, M.D., HAROLD R. ROBERTS, M.D.JOHN J. STUART, M.D.Search for more papers by this author, HAROLD R. ROBERTS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-4-490_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent paper by Targan, Chassin, and Guze (1) reporting a case of Dilantin-induced disseminated intravascular coagulation prompts us to report a similarcase in which isoniazid was the offending drug.A 58-year-old black woman was admitted to another hospital on 11 October 1975 because of syncope and fever. Six months previously, she had been placed on prednisone for rheumatoid lung disease. A chest X ray showed marked chronic obstructive lung disease and infiltrates in the right upper and lower lobes. Several sputum smears were positive for acid-fast organisms, later identified asMycobacterium intracellulare. She was begun...References1. TARGAN S, CHASSIN M, and GUZE L: Dilantin®-induced disseminated intravascular coagulation with purpura fulminans. A case report. Ann Intern Med 83:227-230, 1975 LinkGoogle Scholar2. RAKE M, PANNELL G, and FLUTE P: Intravascular coagulation in acute hepatic necrosis. Lancet 1:534-537, 1970 Google Scholar3. JONES C, BIRCH C, and POLLER L: Disseminated intravascular coagulation associated with hepatitis in late pregnancy. Gut 14:891-894, 1973 CrossrefMedlineGoogle Scholar4. ROBERTS H and CEDARBAUM A: The liver and blood coagulation: physiology and pathology. Gastroenterology 63:297-320, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN J. STUART, M.D.; HAROLD R. ROBERTS, M.D.Affiliations: Department of Medicine University of North Carolina School of Medicine Chapel Hill, North Carolina 27514 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFatal Isoniazid PoisoningA review of blood dyscrasias induced by the antituberculosis drugsOther Antibacterial DrugsSurvival of a Patient with Pancytopenia and Disseminated Coagulation Associated with Miliary Tuberculosis 1 April 1976Volume 84, Issue 4Page: 490-491KeywordsDisseminated intravascular coagulationDrugsFeversIsoniazidLungsMycobacterium avium complexSputumSyncopeThorax ePublished: 1 December 2008 Issue Published: 1 April 1976 PDF downloadLoading ...
Why I Will Continue to Screen Prostate-Specific Antigen for Myself and Other Appropriate Men—Reply
Authors: Mitchell H. Katz
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Fighting for the environment, the unemployed, and the isolated
Authors: Z. Kmietowicz
Journal: BMJ (2010)

The four teams, out of 30 nominated, that made the shortlist for the BMJ Group award for corporate social responsibility each bring a different but strong case for the prize.

Two of those shortlisted chose to tackle perhaps the most pressing issue the world has ever faced by taking action to limit their organisation’s impact on the environment.

Users of health services provided by Southern Health in Melbourne, which operates across 40 sites, including six major hospitals, might not realise it, but the water with which they flush the toilet is captured from dialysis reverse osmosis equipment. They might also not notice that the air conditioning at the various sites is very finely tuned, never running too hot or too cold. But they do know that they have to switch off lights and computers when not in use and use the recycling bins whenever possible.

These and other efforts have resulted in an estimated saving of 35 million litres of water a year, 2 544 402 kWh of electricity and 1390 tonnes …
RICKETS RARE IN PUERTO RICO
Authors: R. C. Williams
Journal: JAMA (1934)

To the Editor:—  InThe Journal, March 24, I have noted the editorial comment pointing out that rickets is undoubtedly a rare disease in Puerto Rico. In Public Health Bulletin 138, which is a report of the tuberculosis survey of the island of Puerto Rico made by Surgeon J. G. Townsend of the Public Health Service from Oct. 11, 1922, to April 18, 1923, this observation was made. The report also contains useful information regarding the prevalence of disease as related to economic conditions.
Science academies of G7 nations call for action on antibiotic resistance and neglected tropical diseases
Authors: M. McCarthy
Journal: BMJ (2015)

In anticipation of the upcoming summit of the G7 group of nations in Bavaria in June, the science academies of the participating nations issued three statements to their governments calling on action to combat antimicrobial resistance, eliminate neglected tropical diseases, and protect the world’s oceans.

The finance ministers of the “Group of 7” nations—Canada, Germany, France, Italy, Japan, the United States, and the United Kingdom—meet periodically to confer on economic policies and cooperation. A representative of the European Union also attends G7 summits. The G7 became the G8 in 1998 after Russia joined the group, but Russia’s membership was suspended in 2014 …
Role of volume in the regulation of vasopressin secretion during pregnancy in the rat.
Authors: W M Barron, B A Stamoutsos, M D Lindheimer
Journal: Journal of Clinical Investigation (1984)

We previously observed that osmoregulation and the osmotic threshold for antidiuretic hormone secretion were altered during pregnancy in Sprague-Dawley rats and the present study evaluated the influence of volume on arginine vasopressin (AVP) release during gestation in this species. Basal plasma osmolality (Posm) and intravascular volume were 297 +/- 3 mosmol/kg and 16.2 +/- 1.2 ml in virgin animals compared with 290 +/- 2 mosmol/kg and 20.2 +/- 2.3 ml in 14-d pregnant rats and 287 +/- 3 mosmol/kg and 25.2 +/- 2.3 ml in 21-d (near-term) pregnant rats (P less than 0.001, each pregnant group vs. virgin). Isosmotic volume depletion was produced by intraperitoneal polyethylene glycol. Volume decreased from 1 to 26% and blood pressure remained stable during decrements as high as 16%. Plasma AVP (PAVP) did not rise significantly in either group of pregnant animals or virgin controls until blood volume depletion reached 6-7%, after which levels rose in a similar exponential manner in virgin, 14-d, and 21-d pregnant animals. In terms of absolute changes, however, PAVP in gravid rats started to increase when intravascular volume was still considerably greater than basal blood volume in the nonpregnant controls. Other experiments, where Posm was increased by intraperitoneal hypertonic saline, reconfirmed that the osmotic threshold for AVP secretion was reduced congruent to 10 mosmol/kg during pregnancy and that AVP release was stimulated by increments in body tonicity as small as 1-2%. In parallel studies, blood volume contraction and increases in Posm were evoked by intraperitoneal polyethylene glycol dissolved in hypertonic saline and results compared with animals receiving intraperitoneal saline alone. Decrements in volume (congruent to 7%), which alone would increase PAVP minimally, increased the sensitivity of the secretory response to changes in osmolality two- to three-fold, an effect which was similar in virgin and gravid animals. Finally, restricting water intake of pregnant rats to that of virgins on days 16-20 of gestation led to suboptimal volume expansion, hypertonicity, and an exaggerated increase in PAVP. These results demonstrate that despite an intravascular space which at term is nearly twice that of virgin rats, pregnant animals secrete AVP in response to fractional volume depletion in a manner similar to nonpregnant controls; that is, the relationship between total blood volume and AVP secretion is altered during gestation such that the expanded blood volume is recognized as normal.
Snowmobile injuries. Hazards from a popular new winter sport
Authors: S. E. Chism
Journal: JAMA (1969)

The recreational use of snowmobiles has increased at a phenomenal rate. The large number of injuries resulting from their operation prompted this preliminary study to determine the mechanism and types of injuries incurred. Often the type of injury can be correlated with the mechanics of snowmobile construction and operation. For example, compression fractures of vetebrae appear to result from inability of the spine to absorb the shock of traveling over irregular terrain. Most fractures, bruises, and lacerations result from faulty operation of the vehicles.
CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs
Authors: Wei Li, Maria Febbraio, Sekhar P. Reddy, Dae-Yeul Yu, Masayuki Yamamoto, Roy L. Silverstein
Journal: Journal of Clinical Investigation (2010)

CD36 is a membrane glycoprotein expressed on platelets, monocytes, macrophages, and several other cell types that was recently demonstrated to be involved in platelet activation in response to oxidized phospholipids, including oxidized LDL. Although the role of CD36 in other vascular cells has not been well defined, previous studies have demonstrated that cd36-knockout (cd36–/–) mice have prolonged thrombosis times after vascular injury, which can be protective in the state of hyperlipidemia. Here, we found significantly less ROS in the vessel walls of cd36–/– mice compared with WT after chemically induced arterial injury, suggesting that CD36 may contribute to ROS generation in the VSMCs themselves. Gene expression analysis revealed that the antioxidant enzymes peroxiredoxin-2 (Prdx2) and heme oxygenase-1 were upregulated in cd36–/– VSMCs. Molecular dissection of the pathway in isolated mouse VSMCs revealed CD36 ligand-dependent induction of Fyn phosphorylation, with subsequent phosphorylation and degradation of the redox-sensitive transcription factor Nrf2. Chromatin immunoprecipitation experiments further showed that Nrf2 directly occupied the Prdx2 promoter. The importance of this pathway was evidenced by increased ROS generation in prdx2–/– mice and decreased thrombosis times in both prdx2–/– and nrf2–/– mice after vascular injury. These data suggest that CD36-mediated downregulation of antioxidant systems in VSMCs may contribute to its prothrombotic, proinflammatory, and atherogenic effects.
Respiratory Virus Infections in R.A.F., 1954-5
Authors: B. E. Andrews, J. C. McDonald, W. B. Thorburn, J. S. Wilson
Journal: BMJ (1956)

MEBIUTIRNSL 1203and the response to vitamin B12 still need to be investigated.May et al. (1950) have suggested that vitamin-C deficiency plays a large part in this disease, but we think this un- likely, as scurvy is very rare in our wards.Zuelzer and Rutzky (1953) state that vitamin C is not specific and that its lack does not prevent the action of folic acid.They further state that all cases invariably responded to folic acid.We agree with this generalization because the " megalo- blastosis" of the bone marrow disappears quickly, and have gained the impression that responses are more rapid if treatment includes intramuscular folic acid. SummaryForty-two cases of megaloblastic anaemia in infancy (5.4% of all admissions) diagnosed during a year by bone-marrow examinations are described.Twenty-two cases suffered from kwashiorkor, the remainder from various infections.The clinical picture and the criteria for bone-marrow diagnosis are described.The results of treatment with folic acid are reported.The mortality rate was 24 %, but in all but one case these deaths were thought to be due to the primary disease or some acute complication.Megaloblastic anaemia of infancy is thought to be a secondary disease; the megaloblastosis of the bone marrow can be cured by giving folic acid, which is specific.We can only speculate on the reasons for now finding this disorder, when five years ago a similar search was unrewarding.