tbuckley/cabot-search huggingface dataset:
A Case Study of the Effect of Hydroxyapatite-Based Soft Tissue Fillers on Bone Scintigraphy
Authors: David Brandon, Dana Mathews, Irfan Farukhi, Philip Shie, Rubjit Chadha, William Erdman, Orhan Oz, Robert Parkey
Journal: Clinical Nuclear Medicine (2006)

Scientific Abstracts: Nine Poster Presentations for the 51st Annual Meeting of the Southwestern Chapter of the Society of Nuclear Medicine April 7-9, 2006, Hyatt Regency, Albuquerque, New Mexico http: //www.swcsnm.org: PDF Only
Promoting blood donation among British Muslims
Authors: A. Sheikh
Journal: BMJ (2003)

The pathophysiological role of the thymus in myasthenia gravis, and the mechanism of therapeutic effect of thymectomy, are incompletely understood. Nevertheless, thymectomy is a valuable treatment modality in selected patients with generalised myasthenia gravis. There are several types of thymectomy operation, but no one operative approach is clearly superior to the others. Total removal of the thymus gland is essential. Additional excision of associated mediastinal and cervical tissue, that may harbor ectopic thymic rests, is a controversial surgical issue. Surgeons that advocate thymectomy through small, cosmetically favourable, incisions usually believe that simple removal of the thymus gland is an adequate operation. Surgeons that emphasise the importance of removing extrathymic tissue, in addition to the thymus gland, usually favour greater operative exposure through a median sternotomy. To minimise operative morbidity, surgery for myasthenia gravis requires a multidisciplinary (neurology, surgery, anaesthesia) approach to peri-operative care.
The In-Training Examination in Internal Medicine
Authors: Joseph J. Nidiry
Journal: Annals of Internal Medicine (2003)

Letters17 June 2003The In-Training Examination in Internal MedicineJoseph J. Nidiry, MDJoseph J. Nidiry, MDHoward University; Washington, DC 20060 (Nidiry)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-12-200306170-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I was somewhat surprised by the conclusion reached by Garibaldi and colleagues (1) about why international medical graduates perform better than U.S. graduates on the IM-ITE. The authors stated, Improvement in performance occurred almost exclusively in international graduates; in particular, it occurred in residents for whom English was not their native language. They went on to conclude that international medical graduates did better on the examination because they got more time to complete it. Because international medical graduates were unfamiliar with the English language, the additional time allowed them to perform better at the end of the ...Reference1. Garibaldi RA, Subhiyah R, Moore ME, Waxman H. The In-Training Examination in Internal Medicine: an analysis of resident performance over time. Ann Intern Med. 2002;137:505-10. [PMID: 12230352] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Joseph J. Nidiry, MDAffiliations: Howard University; Washington, DC 20060 (Nidiry) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe In-Training Examination in Internal Medicine: An Analysis of Resident Performance over Time Richard A. Garibaldi , Raja Subhiyah , Mary E. Moore , and Herbert Waxman The In-Training Examination in Internal Medicine Robin Dibner , Julia Andrieni , and Lawrence Smith The In-Training Examination in Internal Medicine Richard A. Garibaldi and Raja Subhiyah The In-Training Examination in Internal Medicine David P. Steensma Metrics 17 June 2003Volume 138, Issue 12Page: 1009-1010KeywordsComputed axial tomographyDecision makingDiagnostic radiologyEmergency medicineGraduate medical educationMagnetic resonance imagingMedical educationOrthopedicsReasoningResidency ePublished: 17 June 2003 Issue Published: 17 June 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Professional ice hockey injuries: a 4 years prospective study
Authors: G Ornon, D Fritschy, J-L Ziltener, J Menetrey
Journal: British Journal of Sports Medicine (2011)

Background Ice Hockey is the fastest team sport with players skating up to 60 km/h and a puck speeding up to 160 km/h. Aggressive contacts between players, rigid obstacles (boards, goalposts), and solid surface may result in high energy trauma and severe injuries despite protective equipments. Precise data at the professional level are lacking. Objective To determine on several seasons the epidemiology of professional ice hockey injuries, the mechanism of injury, and risk factors to allow the development of a prevention program. Material and Methods All injuries occurring in one of the best Swiss Professional Hockey Team were recorded and monitored during 4 years. Injuries were graded as minor (time loss: 1–7 days), moderate (8–28 days), and major (&gt;28 days). Results Incidence of injury was 6.48/1000 h/player and was stable over the 4 years of observation. Incidence of injury resulting in time loss was 2.3/1000 h/player (forwards: 2.6, defensemen: 2.0, goalies: 0.68). Most of the lesions were moderate (51%), (minor 36%, major 13%). Collision between players was the most common mechanism of moderate to severe injury. Contusions were the most frequently seen injuries (38%) tracked by strains/sprains (29%). Knee and shoulder were the most frequently injured part of body (both 12%). Concussion had a higher incidence in defensemen (0.64/player/1000 h) compared to forwards (0.2/player/1000 h). August (beginning of the ice summer camp) was the month with the highest injury rate with and without time loss (18.7% and 18.6% respectively). Conclusions In spite of its kinetics, ice hockey injuries rate is comparable to other contact team sports. Risk factors are first month of the season, summer training deficiency, to be a defenseman for concussion, collision between players out of the board. Measures of prevention might include optimal physical conditioning before and during the season, stronger helmet for defenseman, beware of contact in the middle of the ice field.
Risk factors in Alzheimer's disease.
Authors: S. Gentleman, G. Roberts
Journal: BMJ (1992)

Dangers of ozone depletion SIR,-The dangers of ozone depletion in the United Kingdom, particularly with regard to non- melanoma skin cancer, are probably much greater than estimated in the recent article on this topic by Fiona Godlee.'The figures given in the article suggest that non-melanoma skin cancer may rise by 8000 cases a year in Britain if there is a 10% reduction in total column ozone.This figure is based on current incidence figures from cancer registries,-which are widely accepted as being gross underestimates.2I recently suggested that the true incidence of non-melanoma skin cancer in England and Wales may be close to 100 000 cases a year.3If this is true then, using a formula devised at the National Cancer Institute, Bethesda, Maryland,4 we might expect something like 35 000 extra non-melanoma skin cancers each year in England and Wales.Furthermore, there would probably be a relative increase in the potentially more dangerous squamous cell carcinoma compared with basal cell carcinoma.'Of course, these figures should not be taken at their face value as it is difficult to give an exact percentage rise in skin cancers because predicting what changes may occur in holiday and clothing habits is impossible.6The article therefore highlights the inadequacy of registration of skin cancer in the United Kingdom.Few attempts have been made to define the extent of the problem, and thus monitoring adequately any changes that may occur in the incidence of skin cancer is going to be impossible.As I have pointed out previously, there is an urgent need to review and improve registration of skin cancer throughout the United Kingdom.
Ireland lacks consensus on neonatal vitamin K prophylaxis
Authors: R. K Philip, R. Gul, M. Dunworth, N. Keane
Journal: BMJ (2001)

EDITOR—Ansell et al reported considerable variations in policies concerning the use of prophylactic vitamin K in the United Kingdom.1 With the published data supporting and not refuting the association of neonatal vitamin K with childhood malignancies, 2 3 the current practice of several policies is of serious concern. A lack of consensus was also shown in a national survey we conducted in the Republic of Ireland.

Relevant information was collected by using a questionnaire from all the 23 maternity units, and …
Spelling of Munchausen: An 'H' of a Mess
Authors: Richard L. Golden
Journal: JAMA (1983)

To the Editor.—  The question of the correct spelling ofMunchausenis a perennial issue well over a century old. The letter of Dr Blodi advocating the doublehspelling ofMunchhausen(1983;249:2019) requires a gentle dissent. The tales of the flamboyant Baron Munchausen were originally written by Rudolf Erich Raspe (1737-1794), who was born in Hanover and fled to England in 1775 to avoid prosecution. The stories were first published as a pamphletin Englishin 1785 under the titleBaron Munchausen's Narrative of His Marvellous Travels and Campaigns in Russia. It was based on the tales of the German soldier and raconteur Hieronymus Karl Friedrich, Freiherr von Munchhausen (1720-1797) of Hanover. Many of these stories, however, can be traced to earlier sources. The first German edition (a free translation of the third English edition) was written by the poet Gottfried August Burger in 1786 (Wunderbare Reisen zu Wasser
MICROVESSELS IN FIBROUS PLAQUE: AN OPTICAL COHERENCE TOMOGRAPHY STUDY
Authors: Lei Xing, Jinwei Tian, Jingbo Hou, Haibo Jia, Koji Kato, Taishi Yonetsu, Soo-Joong Kim, Yu Huai, Xuefeng Ren, Xingtao Huang, Shaosong Zhang, Bo Yu, Ik-Kyung Jang
Journal: Journal of the American College of Cardiology (2012)
QUALITY OF LIFE IN HEART FAILURE PATIENTS CORRELATES BETTER WITH 123I-MIBG THAN EJECTION FRACTION
Authors: Claudio Tinoco Mesquita, Amorim Luana, Sandra M. Miranda, Jader Azevedo, Antonio Nobrega, Leandro Messias, Evandro Mesquita
Journal: Journal of the American College of Cardiology (2012)
Clinical In Vitro Fertilization
Authors: Norbert Gleicher
Journal: JAMA (1984)

This book on in vitro fertilization is edited by two of the most prominent people in the field. Both carry responsibility for one of the most successful in vitro fertilization programs in the world—the Queen Victoria Medical Centre in Melbourne, Australia. However, contrary to some other books on the topic, this monograph does not restrict itself to the experience of one large center. With many contributors from some of the other highly successful Australian in vitro programs, this book, in fact, summarizes the Australian experience. And this is one of the major reasons why this monograph is a must for everybody interested in the subject of in vitro fertilization. In the preface, the editors correctly remind us that Edwards and Steptoe first described the technique of in vitro fertilization and, in Cambridge, later achieved the birth of the first two normal neonates. From very early on, the collaboration between Cambridge
Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability.
Authors: S Rajagopalan, X P Meng, S Ramasamy, D G Harrison, Z S Galis
Journal: Journal of Clinical Investigation (1996)

Vulnerable areas of atherosclerotic plaques often contain lipid-laden macrophages and display matrix metalloproteinase activity. We hypothesized that reactive oxygen species released by macrophage-derived foam cells could trigger activation of latent proforms of metalloproteinases in the vascular interstitium. We showed that in vivo generated macrophage foam cells produce superoxide, nitric oxide, and hydrogen peroxide after isolation from hypercholesterolemic rabbits. Effects of these reactive oxygens and that of peroxynitrite, likely to result from simultaneous production of nitric oxide and superoxide, were tested in vitro using metalloproteinases secreted by cultured human vascular smooth muscle cells. Enzymes in culture media or affinity-purified (pro-MMP-2 and MMP-9) were examined by SDS-PAGE zymography, Western blotting, and enzymatic assays. Under the conditions used, incubation with xanthine/xanthine oxidase increased the amount of active gelatinases, while nitric oxide donors had no noticeable effect. Incubation with peroxynitrite resulted in nitration of MMP-2 and endowed it with collagenolytic activity. Hydrogen peroxide treatment showed a catalase-reversible biphasic effect (gelatinase activation at concentrations of 4 microM, inhibition at > or = 10-50 microM). Thus, reactive oxygen species can modulate matrix degradation in areas of high oxidant stress and could therefore contribute to instability of atherosclerotic plaques.
Adaptation of the Erlangen Active Simulator for Interventional Endoscopy (EASIE) Model for Transmural Pancreatic Pseudocyst Drainage
Authors: R. Schöfl, B. Buchmeier, G. Hauder
Journal: Endoscopy (2006)

Gaining competence in rarely performed interventional procedures is difficult. We present here a pig model for endoscopic drainage of pancreatic pseudocysts and describe its preparation and the procedure. Endoscopic drainage of pancreatic pseudocysts through the wall of the gastrointestinal tract is a challenging procedure for any endoscopist because of the need to cross the peritoneal cavity [1]. The caseload of many endoscopy centres is usually relatively small and may only amount to five to 20 procedures per year, and the opportunities for teaching and learning are limited. We considered that the Erlangen Active Simulator for Interventional Endoscopy (EASIE) model for endoscopic retrograde cholangiopancreatography designed by Hochberger and Maiss might be suitable [2]. This model consists of a pig esophagus, stomach and duodenum with the ligamentum hepatoduodenale, the whole biliary system and the liver, lying in a plastic box; it does not have a pancreas because the pig pancreas does not drain via the main papilla.
HUMORAL MARKERS, CONVENTIONAL DOPPLER ECHOCARDIOGRAM AND BIDIMENSIONAL STRAIN IN THE DETECTION OF MYOCARDIAL TOXIC EFFECT SECONDARY TO CHEMOTHERAPY
Authors: Sergio J. Baratta, Alejandro Benticuaga Navas, Jose Trucco, Demian Chejtman, Maria Noelia Brenzoni, Mercedes Rojas, Renzo E. Melchiori, Jorge Bilbao, Horacio Fernandez, Alejandro Hita
Journal: Journal of the American College of Cardiology (2014)
Avulsion fracture of the ischial tuberosity in adolescents—an easily missed diagnosis
Authors: Sam Gidwani, Jakub Jagiello, Martin Bircher
Journal: BMJ (2004)

Avulsion fracture of the ischial tuberosity is a rare injury in comparison with mid-substance tears of the hamstrings, and its diagnosis is often missed. Such fracture usually occurs between puberty and late adolescence in those who do a lot of sport—it is in puberty that the secondary ossification centre or apophysis appears and in late adolescence that it fuses. In other words, fracture occurs at a time when the apophysis is the weakest link in the chain of muscle, tendon, and bone. The cause is usually forcible contraction of the hamstrings, as in sports such as sprinting and hurdling.

In adolescent patients with a history of proximal hamstring injury and current ischial tenderness, a radiograph of the pelvis should be performed. This is to exclude the presence of an avulsion fracture, which may be substantially displaced.

A prompt diagnosis of a displaced avulsion fracture of the ischial tuberosity will enable early surgery where appropriate. This in turn will prevent the development of chronic pain on sitting and walking and an inability to return to sporting activities.

### Case 1

A 14 year old boy was sprinting during a 200 m race when he suddenly developed a severe pain posteriorly in the proximal part of his left thigh. He collapsed to the ground in pain and could not complete the race.

His general practitioner advised him to rest to allow the presumed hamstring injury to settle. Despite prolonged physiotherapy, he still had pain when he jogged. Two years after the injury, he was referred to …
Fulminant metastatic spread in a patient with an early gastric cancer
Authors: B. Walter, A. Probst, B. Märkl, T. Wagner, M. Anthuber, H. Messmann
Journal: Endoscopy (2009)

A patient with an early gastric cancer was treated initially by endoscopic submucosal dissection (ESD) at our hospital. The resected specimen showed a depth of submucosal infiltration of more than 500 µm. Therefore, in accordance with the extended criteria with regard to EMR, the patient underwent gastrectomy. The TNM stage was pT1 (sm3), pN0 (0 / 58), cM0, L0, V0, G2 after surgery (UICC stage Ia). At 3 months later ultrasound revealed a new mass in the liver, and biopsy showed a rapidly growing metastasis of the gastric adenocarcinoma. Finally, immunohistochemical analysis of all the lymph nodes of the resected stomach revealed a micrometastasis (3mm) directly under the ESD site. The patient died 6 months later. This clinical case highlights the risk of affected lymph nodes in early gastric cancer and the consequent risk of metastasis which increases with greater depth of infiltration to the submucosa.
Mapping the HLA ligandome landscape of acute myeloid leukemia: a targeted approach toward peptide-based immunotherapy
Authors: C Berlin, D J Kowalewski, H Schuster, N Mirza, S Walz, M Handel, B Schmid-Horch, H R Salih, L Kanz, H-G Rammensee, S Stevanović, J S Stickel
Journal: Leukemia (2014)
Weight set-point theory and the high-density lipoprotein concentrations of long-distance runners
Authors: Paul T. Williams
Journal: Metabolism (1990)

Long-distance runners have higher high-density lipoprotein (HDL)-cholesterol concentrations and lower adiposity than sedentary men. Most cross-sectional studies claim that the runners' elevated HDL-cholesterol is not due to the runners' leanness. However, when cross-sectional studies use analysis of covariance (ANCOVA) to adjust for adiposity, or when they compare runners with lean sedentary men, they make an incorrect tacit assumption. They assume that the relationship between change in adiposity and change in HDL-cholesterol in men who have lost fat by running is the same as the cross-sectional difference in HDL-cholesterol between naturally fat and lean sedentary men. Regression slopes for HDL-cholesterol versus adiposity during and at the end of 1 year of running in 35 initially sedentary men suggest this assumption is incorrect; the increase in HDL-cholesterol that accompanies weight loss () is considerably greater than the increase in HDL-cholesterol that is associated with lower adiposity crosssectionally (). These results suggest the following theory: long-distance runners have the HDL metabolism of men who are below their sedentary set-point weight rather than the HDL metabolism of men who are naturally lean without exercising or dieting. This theory was applied to data from 23 published comparisons between long-distance runners and sedentary men. The differences were highly correlated (r = .80) with the theory's predictions (ie, the HDL-cholesterol differences predicted by applying the regression slope for change in HDL-cholesterol v change in adiposity to the average differences in adiposity between the runners and sedentary men). These analyses suggest that comparing long-distance runners to a reference population suitably matched for adiposity, and adjusting for adiposity by ANCOVA may each seriously underestimate the contribution of the runners' leanness to their HDL concentrations. These results suggest that the elevated HDL-cholesterol concentrations of long-distance runners is primarily a phenomenon of reduced adiposity.
Social Psychiatry: An Overview
Authors: RANSOM J. ARTHUR
Journal: American Journal of Psychiatry (1973)

Social psychiatry, which includes the study of the impingement of social phenomena upon the genesis, manifestations, and treatment of mental and physical illness, has in recent decades become an increasingly important part of psychiatry. The epidemiology and taxonomy of mental illness, social factors in the onset and course of disease, transcultural psychiatry, the hospital viewed in social terms, and community psychiatry are all fields that have shown great expansion. But the results of the experiences of community psychiatry and of social psychiatric studies have played a major role in the development of a crisis of identity within the profession of psychiatry; the appropriate education and professional activities for a psychiatrist are currently in dispute. The author discusses the impact of the rise of social psychiatry and the correspondingly great increase in knowledge of biological psychiatry on the possible future functions and education of the psychiatrist.
HER-2 and topoisomerase IIa gene alterations in male breast cancer.
Authors: C Rudlowski, E Wardelmann, S Merkelbach-Bruse, R Buettner, W Kuhn, H Schildhaus
Journal: Cancer Research (2009)

Abstract Abstract #4128 Background:&amp;#x2028; In accordance to the guidelines for female breast cancer and due to more advanced tumor stages at diagnosis primary male breast cancer (MBC) is treated predominantly with anthracycline-based chemotherapeutic regimens. However, amplification of the HER2 and topoisomerase IIalpha (TOPO2A) genes has been linked to the effects of anthracyclines in female breast cancer. Presently no data are available reporting the percentage of TOPO2A amplification/deletion and its potential clinical impact on MBC. Here we present first data about HER2 and TOPO2A genomic alteration in MBC.&amp;#x2028; Patients and Methods:&amp;#x2028; We studied HER2 amplification and TOPO2A amplification/deletion (by fluorescence in situ hybridization) and HER2 protein expression (by immunohistochemical analysis) in 96 primary invasive MBC's using tissue microarrays. A gene copy number/chromosome 17 copy number ratio of 2.0 respectively 1.8 or higher indicated amplification of HER2 and TOPO2A. A TOPO2A/chromosome 17 ratio of less than 0.8 indicated gene deletion. In addition, HER2 protein expression was scored according to standard HercepTest guidelines (DAKO, Carpenteria, CA). Tumor characteristics and follow-up data were available and correlated with HER2/TOPO2A gene alterations and HER2 protein expression.&amp;#x2028; Results:&amp;#x2028; 91/96 cases were evaluable for TOPO2A/HER2 assessment. HER2 gene amplification were found in 6 cases (6,25%) of which 3 were classified as 3+, 2 as 2+ and 1 as 1+ positive for protein expression. TOPO2A amplification/deletion showed 3 patients (3.1%), 2 with amplification and one with a deletion. Only one patient had both HER2 and TOPO2A gene amplification. HER2/TOPO2A gene alterations were not related to the tumor characteristics, response to therapy or the patients survival.&amp;#x2028; Conclusion:&amp;#x2028; In female breast cancer recent studies have suggested that deletions or amplifications of the TOP2A gene are associated with poor prognosis and predictive of greater response to anthracycline-containing than to non-anthracycline-containing regimens. In this study group both HER2 and TOPO2A gene alterations were rare events. A simultaneous amplification was observed in only one case. Our data for MBC suggest that due to the low number of TOPO2A gene amplification/deletion the clinical significance of TOPO2A is of limited value. Based on these findings the role of anthracycline-containing regimens for MBC has necessarily to be defined. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 4128.