tbuckley/cabot-search huggingface dataset:
Diabetes, Metabolic Syndrome, and Obesity in Relation to Serum Dioxin Concentrations: The Seveso Women’s Health Study
Authors: Marcella Warner, Paolo Mocarelli, Paolo Brambilla, Amelia Wesselink, Steven Samuels, Stefano Signorini, Brenda Eskenazi
Journal: Environmental Health Perspectives (2013)

Background: In animal studies, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters glucose transport and increases serum lipid levels and blood pressure. Epidemiologic evidence suggests an association between TCDD and metabolic disease.Objectives: On 10 July 1976, a chemical explosion in Seveso, Italy, resulted in the highest known residential exposure to TCDD. Using data from the Seveso Women’s Health Study (SWHS), a cohort study of the health of the women, we examined the relation of serum TCDD to diabetes, metabolic syndrome, and obesity &gt; 30 years later.Methods: In 1996, we enrolled 981 women who were newborn to 40 years of age in 1976 and resided in the most contaminated areas. Individual TCDD concentration was measured in archived serum that had been collected soon after the explosion. In 2008, 833 women participated in a follow-up study. Diabetes was classified based on self-report or fasting serum glucose and glycated hemoglobin levels. Metabolic syndrome was defined by International Diabetes Federation criteria. Obesity was defined as body mass index ≥ 30 kg/m2.Results: A 10-fold increase in serum TCDD (log10TCDD) was not associated with diabetes (adjusted hazard ratio = 0.76; 95% CI: 0.45, 1.28) or obesity [adjusted odds ratio (OR) = 0.80; 95% CI: 0.58, 1.10]. Log10TCDD was associated with metabolic syndrome, but only among women who were ≤ 12 years of age at the time of the explosion (adjusted OR = 2.03; 95% CI: 1.25, 3.29; pinteraction = 0.01).Conclusions: We found an increased prevalence of metabolic syndrome associated with TCDD, but only among women who were the youngest at the time of the explosion. Continued follow-up of the SWHS cohort will be informative.
1068-121 Impact of myocardial viability assessment on the beneficial effect of cardiac resynchronization therapy in patients with ischemic cardiomyopathy
Authors: Jacopo Dalle Mule, Renzo Perelli, Marco Mazzella, Felice Martinelli, Alessandro Proclemer, Virginia Scarabeo, Maria Liberata Di Sipio
Journal: Journal of the American College of Cardiology (2004)
Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia.
Authors: D A Brenner, M Buck, S P Feitelberg, M Chojkier
Journal: Journal of Clinical Investigation (1990)

The mechanisms responsible for decreased serum albumin levels in patients with cachexia-associated infection, inflammation, and cancer are unknown. Since tumor necrosis factor-alpha (TNF alpha) is elevated in cachexia-associated diseases, and chronic administration of TNF alpha induces cachexia in animal models, we assessed the regulation of albumin gene expression by TNF alpha in vivo. In this animal model of cachexia, Chinese hamster ovary cells transfected with the functional gene for human TNF alpha were inoculated into nude mice (TNF alpha mice). TNF alpha mice became cachectic and manifested decreased serum albumin levels, albumin synthesis, and albumin mRNA levels. However, even before the TNF alpha mice lost weight, their albumin mRNA steady-state levels were decreased approximately 90%, and in situ hybridization revealed a low level of albumin gene expression throughout the hepatic lobule. The mRNA levels of several other genes were unchanged. Hepatic nuclei from TNF alpha mice before the onset of weight loss were markedly less active in transcribing the albumin gene than hepatic nuclei from control mice. Therefore, TNF alpha selectively inhibits the genetic expression of albumin in this model before weight loss.
Myocardial depressant effects of sodium acetate
Authors: P. L. KIRKENDOL, J. E. PEARSON, J. D. BOWER, R. D. HOLBERT
Journal: Cardiovascular Research (1978)

Journal Article Myocardial depressant effects of sodium acetate Get access PAUL L. KIRKENDOL, PAUL L. KIRKENDOL 1 From the Department of Pharmacology and Medicine, Louisiana State University Medical Center, 1Reprint requests to: Dr Paul L. Kirkendol, Department of Pharmacology, LSU Medical Center, 1100 Florida Avenue, New Orleans, La 70119, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar JAMES E. PEARSON, JAMES E. PEARSON From the Department of Pharmacology and Medicine, Louisiana State University Medical Center, Search for other works by this author on: Oxford Academic PubMed Google Scholar JOHN D. BOWER, JOHN D. BOWER From the Department of Pharmacology and Medicine, Louisiana State University Medical Center, Search for other works by this author on: Oxford Academic PubMed Google Scholar ROBERT D. HOLBERT ROBERT D. HOLBERT From the Department of Pharmacology and Medicine, Louisiana State University Medical Center, Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 12, Issue 2, February 1978, Pages 127–136, https://doi.org/10.1093/cvr/12.2.127 Published: 01 February 1978
Low molecular weight heparin stimulates megakaryocytopoiesis in bone-marrow transplantation patients
Authors: Reuven Or, Sharon Elad, Ofer Shpilberg, Amiram Eldor
Journal: American Journal of Hematology (1996)

The use of low molecular weight heparin (LMWH) as prophylaxis for veno-occlusive disease of the liver has been studied in patients undergoing bone marrow transplantation (BMT). The present study analyzes the effect of LMWH on the time course of platelet recovery after BMT. Significantly accelerated platelet recovery in conjunction with lessened requirements of platelet transfusions was observed in the LMWH-treated patients.
Neutrophils from allergic asthmatic patients produce and release metalloproteinase‐9 upon direct exposure to allergens
Authors: I. Ventura, A. Vega, P. Chacón, C. Chamorro, R. Aroca, E. Gómez, V. Bellido, Y. Puente, M. Blanca, J. Monteseirín
Journal: Allergy (2014)

Abstract Background Asthma is characterized by airway inflammation and remodelling in which matrix metalloproteinases ( MMP s) play an important role. MMP ‐9 is the major MMP found in the bronchoalveolar lavage fluids and bronchial biopsies from patients with allergic asthma after allergen challenge, where it correlates with the count of neutrophils and macrophages. However, the cellular sources of MMP ‐9 in this inflammatory condition have not yet been clearly identified. This work was undertaken to analyse whether neutrophils may be a source of MMP ‐9 in the allergic asthma condition upon allergen challenge. Methods Neutrophils from allergic asthmatic patients were in vitro stimulated, and the levels of MMP ‐9 release were measured in the cell culture supernatants using enzyme‐linked immunosorbent assay ( ELISA ) and zymography. Results We show that MMP ‐9 is released by neutrophils, but not by eosinophils from allergic asthmatic patients in response to allergens to which the patients were sensitized. Neutrophils also released MMP ‐9 in response to anti‐IgE Abs, and agonist Abs against Fcε RI , Fcε RII / CD 23 and galectin‐3. Inhibitors of transcription and translation, actinomycin D and cycloheximide, partially cancelled this process, suggesting that MMP ‐9 is also de novo synthesized in response to stimuli. We also show evidence that the MAPK s, p38 and extracellular signal‐regulated kinase, as well as the transcription factor NF ‐κB, are involved, as specific chemical inhibitors of these cell‐signalling pathways abolished the anti‐IgE/allergen‐dependent MMP ‐9 release. Conclusions These data demonstrate that the exposure of neutrophils to allergens leads to generation of MMP ‐9, which may then lead to remodelling in asthma.
Trivalent Botulinus Antitoxin
Authors: M. GLENN KOENIG
Journal: Annals of Internal Medicine (1969)

Editorial Notes1 March 1969Trivalent Botulinus AntitoxinM. GLENN KOENIG, M.D., F.A.C.P.M. GLENN KOENIG, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-3-643 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe need for a trivalent botulinus antitoxin containing antitoxins A, B, and E has long been recognized (1, 2). Thus, the licensure of such a preparation and its availability from the National Communicable Disease Center in Atlanta is welcome news (3). Formerly, only bivalent A, B antitoxin was licensed in this country despite the increased incidence of type E disease since 1960; furthermore, from 1960 through 1967 type E botulism has had a death-to-case ratio over twice that reported for type A and four times that reported for type B disease (3). It is true that most instances of type...References1. DOLMAN CE, TOMISCH M, CAMPBELL CC, and LAING WB: Fish eggs as a cause of human botulism: two outbreaks in British Columbia due to types A and B botulinus toxins. J. Infect. Dis. 106: 5, 1960. CrossrefMedlineGoogle Scholar2. KOENIG MG, SPICKARD A, CARDELLO MA, and ROGERS DE: Clinical and laboratory observations on type E botulism in man. Medicine (Balt.) 43: 517, 1963. CrossrefGoogle Scholar3. Trivalent botulinus antitoxin. Botulism-United States 1899-1967: surveillance summary. Morbid. Mortal. Weekly Rep. 17: 444, 1968. Google Scholar4. BURKE V and ELDER JC: Treatment in botulism. Arch. Intern. Med. (Chicago) 27: 265, 1921. CrossrefGoogle Scholar5. DACK GM: Food Poisoning, 3rd ed., The University of Chicago Press, Chicago, 1962, p. 72. Google Scholar6. DOLMAN CE and IIDA H: Type E botulism: its epidemiology, prevention, and specific treatment. Canad. J. Pub. Health 54: 293, 1963. MedlineGoogle Scholar7. WHITTAKER RL, GILBERTSON RB, and GARRETT AS: Botulism, type E: report of eight simultaneous cases. Ann, Intern. Med. 61: 448, 1964. LinkGoogle Scholar8. SEMERAU M and NOACK K: Beitrage zur frage des botulismus. Z. Klin. Med. 88: 304, 1919. Google Scholar9. SCHNEIDER HJ and FISK R: Botulism: demonstration of toxin in blood and tissues. JAMA 113: 2299, 1939. Google Scholar10. Botulism—Kansas. Morbid Mortal. Weekly Rep. 13: 423, 1964. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: M. GLENN KOENIG, M.D., F.A.C.P.Affiliations: Department of Medicine Vanderbilt University School of Medicine Nashville, Tenn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBotulinum Neurotoxins and Botulism: A Novel Therapeutic ApproachType E botulismLe botulisme en IranAnaerobic Infections 1 March 1969Volume 70, Issue 3Page: 643-645KeywordsAntitoxinsBotulism ePublished: 1 December 2008 Issue Published: 1 March 1969 PDF downloadLoading ...
Computed tomography in the investigation of dementia.
Authors: J R Bradshaw, J L Thomson, M J Campbell
Journal: BMJ (1983)

To assess the value of computed tomography in investigating patients with dementia, 500 consecutive patients presenting with a provisional clinical diagnosis of dementia of recent onset were reviewed and the results analysed in a computer. Most patients had either cerebral atrophy or infarction, but 82 patients had a normal scan and 42 others had tumours. More than 10% of all patients, including 5% with no other symptoms or signs, had a treatable lesion. Various associated symptoms and signs were useful pointers to such a treatable lesion and clearly indicated computed tomography. Accurate diagnosis is the cornerstone of proper management, and if a few patients with treatable lesions can be identified then the benefits to all concerned may be incalculable.
Effects of Atrial Fibrillation on Exercise Performance in Patients with Cardiac Disease
Authors: TOM R. HORNSTEN, ROBERT A. BRUCE
Journal: Circulation (1968)

Cardiac performance in 25 male and 40 female cardiac patients with atrial fibrillation was compared with that of age, sex, and function-matched controls with sinus rhythm. All had rheumatic valvular heart disease treated with digitalis. Multistage maximal exercise was tested on a motor-driven treadmill with increasing work loads every 3 minutes to the limits of fatigue. Mean heart rates of patients with atrial fibrillation were greater at rest, at all levels of exercise, and immediately after it regardless of sex or anatomic lesion; however, recovery heart rate was significantly higher in the males than in the females with sinus rhythm. As is true for normals, mean duration and intensity of exercise was greater in male than in female cardiac patients regardless of rhythm or anatomic lesion.
PREDICTORS OF IN-HOSPITAL AND LONG TERM MORTALITY IN PATIENTS WITH ACUTE PULMONARY EMBOLISM
Authors: Ozlem Yildirimturk, Zekeriya Nurkalem, Kazim Serhan &Ouml;zcan, Servet Altay, Se&ccedil;kin Satilmis, Emrah Bozbeyoglu
Journal: Journal of the American College of Cardiology (2012)
Involvement of carbohydrate on phospholipase A<sub>2</sub>, a bee-venom allergen, in<i>in vivo</i>antigen-specific IgE synthesis in mice
Authors: M Okano, Ar Satoskar, Da Harn, K Nishizaki, M Okano, Y Masuda, T Yoshino
Journal: Allergy (1999)

Carbohydrates on allergens are known to be important for allergenicity. However, most findings have been made with epitope analysis. In this study, we investigated the involvement of N-glycan on phospholipase A2 (PLA2), the major allergen of honeybee venom, in in vivo synthesis of specific IgE in mice.CBA/J and C57BL/6 mice were sensitized intranasally with either native or deglycosylated PLA2 in the absence of adjuvant. After repeated sensitization, serum Ab titers against PLA2 were determined. PLA2 was deglycosylated chemically with anhydrous trifluoromethanesulfonic acid (TFMS).CBA/J mice showed PLA2-specific IgE production after repeated sensitization with native PLA2. They also produced PLA2-specific IgG1 predominantly, suggesting that Th2-type Ab production was induced. When we used deglycosylated PLA2 as a competitor in ELISA for detecting PLA2-specific IgE, deglycosylated PLA2 completely inhibited the binding between native PLA2 and IgE. Deglycosylated PLA2 had the same potential for inducing specific IgE synthesis as native PLA2, since sensitization with deglycosylated PLA2 also elicited IgE production in CBA/J mice.These results suggest that carbohydrate on PLA2 is less important than previously thought not only as a dominant IgE epitope but also in synthesis of PLA2-specific IgE in vivo.
How should we talk to patients with acute leukaemia?
Authors: R. Twycross
Journal: BMJ (1981)

It is of more direct interest to the clinical psychiatrist, and so for me poses the most questions.The author gives a brief descriptive account of his wife's serious suicidal impulses in the course of a puerperal psychosis, being apparently unaware that such conditions are well recognised and that effective treatment is available.The terms mental illness, psychosis, and psychiatrist do not appear in the article: it would be appropriate reading for those who talk of the "myth" of mental illness, or of the psychotic person's "right" to refuse care and treatment.This moving account and its conclusion, in ignorance, that medicine knows or cares little about such reactions to childbirth makes one wonder anew how psychiatry can more effectively and acceptably transmit its knowledge and skills to medical and wider audiences.These three papers have pointed valuably to gaps in the current delivery of health care, no doubt in part representing inadequacies in medical education.
Donor leukocyte infusion after hematopoietic stem cell transplantation in patients with juvenile myelomonocytic leukemia
Authors: A Yoshimi, P Bader, S Matthes-Martin, J Starý, P Sedlacek, U Duffner, T Klingebiel, D Dilloo, W Holter, F Zintl, B Kremens, K-W Sykora, C Urban, H Hasle, E Korthof, T Révész, A Fischer, P Nöllke, F Locatelli, C M Niemeyer
Journal: Leukemia (2005)
Adipose tissue isomeric trans fatty acids and risk of myocardial infarction in nine countries: the EURAMIC study
Authors: A. Aro, I. Salminen, J.K. Huttunen, A.F.M. Kardinaal, P. van't Veer, J.D. Kark, R.A. Riemersma, M. Delgado-Rodriguez, J. Gomez-Aracena, L. Kohlmeier, M. Thamm, B.C. Martin, J.M. Martin-Moreno, V.P. Mazaev, J. Ringstad, F.J. Kok
Journal: The Lancet (1995)
Randomized trial comparing fanning with standard technique for endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic mass lesions
Authors: J. Bang, S. Magee, J. Ramesh, J. Trevino, S. Varadarajulu
Journal: Endoscopy (2013)

<b>Background and study aims:</b> The fanning technique for endoscopic ultrasound-guided fine-needle aspiration (EUS – FNA) involves sampling multiple areas within a lesion with each pass. The aim of this study was to compare the fanning and standard techniques for EUS – FNA of solid pancreatic masses. <b>Patients and methods: </b>Consecutive patients with solid pancreatic mass lesions were randomized to undergo EUS – FNA using either the standard or the fanning technique. The main outcome measure was the median number of passes required to establish diagnosis. The secondary outcome measures were the diagnostic accuracy, technical failure, and complication rate of the two techniques. <b>Results:</b> Of 54 patients, 26 were randomized to the standard technique and 28 to the fanning technique. There was no difference in diagnostic accuracy (76.9 % vs. 96.4 %; <i>P</i> = 0.05), technical failure or complication rates (none in either cohort). There was a significant difference in both the number of passes required to establish diagnosis (median 1 [interquartile range 1 – 3] vs. 1 [1 – 1]; <i>P</i> = 0.02) and the percentage of patients in whom a diagnosis was achieved on pass one (57.7 % vs. 85.7 %; <i>P </i> = 0.02) between the standard and fanning groups, respectively. <b>Conclusions:</b> The fanning technique of FNA was superior to the standard approach because fewer passes were required to establish the diagnosis. If these promising data are confirmed by other investigators, consideration should be given to incorporating the fanning technique into routine practice of EUS – FNA. Registered at Clinical Trials.gov (NCT 01501903).
Multitarget Therapy of Lupus Nephritis
Authors: Richard J. Glassock
Journal: Journal of the American Society of Nephrology (2008)

In the Fall of each year, the attention of many Americans is diverted to their national pastime—baseball—and to base hits and home runs. The former often lack any definitive impact on the outcome of the game, but the latter usually have a decided effect, noted immediately. This analogy has its
Treatment of Torulopsis glabrata Peritonitis With Intraperitoneal Amphotericin B
Authors: Peter S. Rahko
Journal: JAMA (1983)

Torulopsis glabrata peritonitis occurred in a patient after surgery for a ruptured abdominal viscus. The infection was successfully treated with intraperitoneal amphotericin B alone. Pharmacokinetic information regarding the distribution and clearance of amphotericin B administered by this route is presented, and the clinical manifestations and treatment modalities for T glabrata and Candida peritonitis are reviewed.
Predictors of Cerebral Arteriopathy in Children With Arterial Ischemic Stroke
Authors: Catherine Amlie-Lefond, Timothy J. Bernard, Guillaume Sébire, Neil R. Friedman, Geoffrey L. Heyer, Norma B. Lerner, Gabrielle deVeber, Heather J. Fullerton
Journal: Circulation (2009)

Background— Cerebral arteriopathies, including an idiopathic focal cerebral arteriopathy of childhood (FCA), are common in children with arterial ischemic stroke and strongly predictive of recurrence. To better understand these lesions, we measured predictors of arteriopathy within a large international series of children with arterial ischemic stroke. Methods and Results— Between January 2003 and July 2007, 30 centers within the International Pediatric Stroke Study enrolled 667 children (age, 29 days to 19 years) with arterial ischemic stroke and abstracted clinical and radiographic data. Cerebral arteriopathy and its subtypes were defined using published definitions; FCA was defined as cerebral arterial stenosis not attributed to specific diagnoses such as moyamoya, arterial dissection, vasculitis, or postvaricella angiopathy. We used multivariate logistic regression techniques to determine predictors of arteriopathy and FCA among those subjects who received vascular imaging. Of 667 subjects, 525 had known vascular imaging results, and 53% of those (n=277) had an arteriopathy. The most common arteriopathies were FCA (n=69, 25%), moyamoya (n=61, 22%), and arterial dissection (n=56, 20%). Predictors of arteriopathy include early school age (5 to 9 years), recent upper respiratory infections, and sickle cell disease, whereas prior cardiac disease and sepsis reduced the risk of arteriopathy. The only predictor of FCA was recent upper respiratory infection. Conclusions— Arteriopathy is prevalent among children with arterial ischemic stroke, particularly those presenting in early school age, and those with a history of sickle cell disease. Recent upper respiratory infection predicted cerebral arteriopathy and FCA in particular, suggesting a possible role for infection in the pathogenesis of these lesions.
Issues in Designing Benefits for Health Care Reform
Authors: Marilyn J. Field
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithinchoesteryl acyltransferase
Authors: Annie M. Bérard, Bernhard Föger, Alan Remaley, Robert Shamburek, Boris L. Vaisman, Glenda Talley, Beverly Paigen, Robert F. Hoyt, Santica Marcovina, H. Bryan Brewer, Silvia Santamarina-Fojo
Journal: Nature Medicine (1997)
Management of malignant pleural effusions.
Authors: M H Tattersall, M J Boyer
Journal: Thorax (1990)

Management of malignant pleural effusionsPleural effusions are a common development in patients with cancer, often posing a considerable management problem.From 28% to 61o% of effusions seen in a general hospital are malignant, '3 and up to half of patients with breast cancer will develop an effusion during the course of their illness.34Other cancers in which pleural effusions occur frequently include lung cancer, ovarian cancer, and the lymphomas.35The prognosis of patients with malignant effusions is generally poor, with a reported 30 day mortality of 29- 500,.67Many patients, however, particularly those with breast cancer, have prolonged survival4 and control of the effusion and the related symptoms is an important issue in management.