Osteonecrosis of the Femoral Head Linked to Topical Steroids for Skin Bleaching: A Case Report
Authors: Renaud Felten, Laurent Messer, Paul Moreau, Raphaelle Goussot, Antoine Mahé
Journal: Annals of Internal Medicine (2014)

Letters18 November 2014Osteonecrosis of the Femoral Head Linked to Topical Steroids for Skin Bleaching: A Case ReportRenaud Felten, MD, Laurent Messer, MD, Paul Moreau, MD, Raphaelle Goussot, MD, and Antoine Mahé, MD, PhDRenaud Felten, MDFrom Hôpital Pasteur, Colmar, France., Laurent Messer, MDFrom Hôpital Pasteur, Colmar, France., Paul Moreau, MDFrom Hôpital Pasteur, Colmar, France., Raphaelle Goussot, MDFrom Hôpital Pasteur, Colmar, France., and Antoine Mahé, MD, PhDFrom Hôpital Pasteur, Colmar, France.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Lighter skin has become a standard of beauty in some countries with populations with darker skin. As a result, many persons from these geographic areas use skin-bleaching compounds that frequently include superpotent topical steroids (1). These steroids lead especially to dermatologic complications, but systemic effects, including serious adverse events, have also been reported (1, 2).Objective: To report what we believe is the first case of steroid-induced osteonecrosis of the femoral head related to the use of topical steroids for skin bleaching.Case Report: A 26-year-old man native to the Democratic Republic of Congo had a 1-year history of ...References1. Mahé A. The practice of skin-bleaching for a cosmetic purpose in immigrant communities. J Travel Med. 2014;21:282-7. [PMID: 24612323] doi:10.1111/jtm.12106 CrossrefMedlineGoogle Scholar2. Sobngwi E, Lubin V, Ury P, Timsit FJ, Gautier JF, Vexiau P. Adrenal insufficiency and diabetes mellitus secondary to the use of topical corticosteroids for cosmetic purpose. Ann Endocrinol (Paris). 2003;64:202-4. [PMID: 12910062] MedlineGoogle Scholar3. Schmitt-Sody M, Kirchhoff C, Mayer W, Goebel M, Jansson V. Avascular necrosis of the femoral head: inter- and intraobserver variations of Ficat and ARCO classifications. Int Orthop. 2008;32:283-7. [PMID: 17396260] CrossrefMedlineGoogle Scholar4. Keane FM, Munn SE, Taylor NF, du Vivier AW. Unregulated use of clobetasol propionate [Letter]. Br J Dermatol. 2001;144:1095-6. [PMID: 11359411] CrossrefMedlineGoogle Scholar5. Takahashi H, Tsuji H, Honma M, Ishida-Yamamoto A, Iizuka H. Femoral head osteonecrosis after long-term topical corticosteroid treatment in a psoriasis patient [Letter]. J Dermatol. 2012;39:887-8. [PMID: 22300106] doi:10.1111/j.1346-8138.2011.01487.x CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Renaud Felten, MD; Laurent Messer, MD; Paul Moreau, MD; Raphaelle Goussot, MD; Antoine Mahé, MD, PhDAffiliations: From Hôpital Pasteur, Colmar, France.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0160. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byL'utilisation cosmétique de produits dépigmentants et ses complicationsAstragalus polysaccharide ameliorates steroid‐induced osteonecrosis of femoral head through miR ‐206/ HIF ‐1α/ BNIP3 axisCircPVT1 up‐regulation attenuates steroid‐induced osteonecrosis of the femoral head through regulating miR‐21‐5p‐mediated Smad7/TGFβ signalling pathwayCircular RNA CDR1as promotes adipogenic and suppresses osteogenic differentiation of BMSCs in steroid-induced osteonecrosis of the femoral headOstéonécroses aseptiques, une revue générale des ostéonécroses de la hanche, et au-delàAssociation between NOS3 polymorphisms and osteonecrosis of the femoral headSkin lightening products’ violations in Europe: An analysis of the rapid alert system for dangerous non-food products 2005–2018Osteonecrosis of the Femoral HeadLes défis de la dépigmentation cosmétique volontaireDifferential proteomic screening and identification for non-traumatic necrotic femoral osseous tissueDermatología de las pieles llamadas «negras»Clobetasol 18 November 2014Volume 161, Issue 10Page: 763-764KeywordsAdrenocorticotropic hormoneCortisolDiabetes mellitusHipPopulation statisticsPropionatesSerious adverse eventsSickle cell diseaseSteroidsSurgeons ePublished: 18 November 2014 Issue Published: 18 November 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...