tbuckley/cabot-search huggingface dataset:
THE INFLUENCE OF THE PARTNER CELL ON THE PRODUCTION OF L VIRUS AND THE EXPRESSION OF VIRAL SURFACE ANTIGEN IN HYBRID CELLS
Authors: Eva Maria Fenyö, Gertrud Grundner, Francis Wiener, Eva Klein, George Klein, Henry Harris
Journal: The Journal of Experimental Medicine (1973)

The C-type particles produced by the A9 and A9HT sublines of mouse L cells were shown to infect C3H (N type), but not C57BL (B type), mouse embryo fibroblasts. Infection was indicated by distinct single giant cell formation in the XC monolayer used to overlay the mouse embryo fibroblasts. On the basis of these results it was concluded that the L cell virus is N tropic. A9 and A9HT cells were fused to various mouse cells derived from tumors and normal tissues. The ability to produce the Moloney-type surface antigen and to release infectious virus was introduced by the A9 component into the hybrid cell. Virus production, measured by antigen induction on JLS-V9 cells, was suppressed in those hybrids in which the partner cell had a genotype determining low infectibility with that particular virus (B-type cell). It thus appears that the major genetic locus affecting resistance to infection with leukemia viruses, the Fv-1 locus, regulates infectious virus production in somatic cell hybrids also. The same genetic locus did not seem to govern the expression of all virus-related functions, for the virus-determined membrane antigen was demonstrated in many of the N x B-type hybrids in which production of infectious virus was suppressed.
INTERVENTIONAL CARDIOLOGY FELLOWS AND PROCEDURAL COMPLICATIONS AFTER PERCUTANEOUS CORONARY INTERVENTION
Authors: Drew S. Allen, Steven P. Marso, David J. Cohen, Kevin F. Kennedy, Jason B. Lindsey, Andrew D. Frutkin, Sameer K. Mehta, Kelly R. O'Neal, Tapas J. Ghose, Steven B. Laster, Joshua M. Stolker
Journal: Journal of the American College of Cardiology (2011)
Furosemide for High Altitude Pulmonary Edema
Authors: Herbert N. Hultgren
Journal: JAMA (1975)

<h3>To the Editor.—</h3> The recent reply to a question regarding first aid equipment and acclimatization in mountain climbing (232:657, 1975) merits comment. Dr Mason suggests that furosemide (Lasix) given in large doses orally and intravenously may have dramatic beneficial effect in the treatment of high altitude pulmonary edema (HAPE). A case is described in which 120 mg orally and 80 mg intravenously were given, resulting in a 4,000-ml diuresis in 6 1/2 hours, with allegedly beneficial results. Unfortunately, such anecdotal reports have led to the indiscriminate use of furosemide in the treatment of HAPE as well as for the prevention of mountain sickness. Recently, a climbing party leader requested information about giving furosemide to all members of his party to prevent mountain sickness! Dr Mason points out that drug prophylaxis has been disappointing. It should be pointed out that there is insufficient evidence from appropriately conducted clinical studies that furosemide
Medicine as a Social Instrument: Preventive Medicine
Authors: W. G. Smillie
Journal: New England Journal of Medicine (1951)

IN ANY consideration of preventive medicine, one encounters a difference of concepts of the subject matter under discussion. What does the field of "preventive medicine" include? What functions of medicine does it encompass? Does it mean the same thing to everyone? How has its meaning changed in fifty years?For the purpose of this discussion, I have arbitrarily decided that preventive medicine shall include as its responsibility all those matters that deal with the prevention of illness and the promotion of health of the individual. This is in contrast to the function of "public health," which encompasses the activities of . . .
Inhibition of prostacyclin by treatment of endothelium with aspirin. Correlation with platelet adherence.
Authors: R L Czervionke, J B Smith, G L Fry, J C Hoak, D L Haycraft
Journal: Journal of Clinical Investigation (1979)

Aspirin treatment of cultured endothelial cells from the umbilical vein increased the adherence of 51Cr-platelets when thrombin was present. If the cyclooxygenase activity of endothelium was inhibited by aspirin, as it is in the platelet, reduction of endogenous prostacyclin (PGI2) production could have been responsible. By correlating thrombin-induced adherence of platelets to endothelial monolayers with PGI2 release (as measured by radioimmunoassay for 6-keto-prostaglandin FI1 alpha [6-keto-PGF1 alpha]), we have demonstrated an inverse relationship between platelet adherence and PGI2 levels. Untreated endothelial monolayers exposed to thrombin and platelets resulted in 4% platelet adherence and 107 nM 6-keto-PGF1 alpha. With 0.1 mM aspirin treatment, which is known to block platelet cyclooxygenase, adherence was 5% and 6-keto-PGF1 alpha decreased to 45 nM. Increasing the aspirin concentration to 1 mM resulted in 44% adherence and less than 3 nM 6-keto-PGF1 alpha. When 25 nM exogenous PGI2 was added to 1 mM aspirin-treated endothelium, adherence returned to 5%. The increase in thrombin-induced platelet adherence to 1 mM aspirin-treated monolayers was reversed 2 h after removal of the aspirin solution. 6-Keto-PGF1 alpha returned to 37% of the untreated monolayer value. Recovery from the aspirin effect did not occur when cycloheximide, an inhibitor of protein synthesis, was present during the 2-h period.
An integrated diagnosis and therapeutic system using intra-operative 5-aminolevulinic-acid-induced fluorescence guided robotic laser ablation for precision neurosurgery
Authors: Hongen Liao, Masafumi Noguchi, Takashi Maruyama, Yoshihiro Muragaki, Etsuko Kobayashi, Hiroshi Iseki, Ichiro Sakuma
Journal: Medical Image Analysis (2010)
Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer
Authors: Julian A. Schardt, Manfred Meyer, Claudia H. Hartmann, Falk Schubert, Oleg Schmidt-Kittler, Christine Fuhrmann, Bernhard Polzer, Marco Petronio, Roland Eils, Christoph A. Klein
Journal: Cancer Cell (2005)
Staying ahead of getting behind: reflections on "scarcity"
Authors: D. Loxterkamp
Journal: BMJ (2014)

No one is busier or needs more bandwidth than a generalist physician



You ramble into the exam room 45 minutes late. The patient is startled, annoyed, but you apologize and ask how you could help. He reaches for a crumpled list and begins a rambling oratory that you are clearly no longer listening to. Slumping on your stool, you stare at a computer screen that displays the “quality measures” you must address today. And so the stage is set . . . 

We have all been there. We will be there later today: hurried, behind, distracted by everything except the one question the patient doesn’t know he needs answered today. Our problem is scarcity of time—if only we had enough to do today’s work well.

A new book by Sendhil Mullainathan and Eldar Shafir1 explores the costs of feeling perpetually behind. Scarcity: Why Having Too Little Means So Much begins as a study about poverty and why people who are poor stay poor. The authors cite numerous laboratory experiments and field studies that elucidate the decision making process of people perpetually on the financial margin. When faced with a money …
Cutaneous anaplastic T-cell lymphoma in a patient with human immunodeficiency virus infection: detection of Epstein–Barr virus DNA
Authors: B. DRENO, B. MILPIED-HOMSI, P. MORKAU, B. BUREAU, P. LITOUX
Journal: British Journal of Dermatology (1993)

Journal Article Cutaneous anaplastic T‐cell lymphoma in a patient with human immunodeficiency virus infection: detection of Epstein–Barr virus DNA Get access B. DRENO, B. DRENO Department of Dermatology, Hôtel Dieu, Place A. Ricordeau. 4403S Nantes cedex 01, France Search for other works by this author on: Oxford Academic Google Scholar B. MILPIED‐HOMSI, B. MILPIED‐HOMSI Department of Dermatology, Hôtel Dieu, Place A. Ricordeau. 4403S Nantes cedex 01, France Search for other works by this author on: Oxford Academic Google Scholar P. MORKAU, P. MORKAU Department of Medicine, Hospital 56100 Lorient, France Search for other works by this author on: Oxford Academic Google Scholar B. BUREAU, B. BUREAU Department of Dermatology, Hôtel Dieu, Place A. Ricordeau. 4403S Nantes cedex 01, France Search for other works by this author on: Oxford Academic Google Scholar P. LITOUX P. LITOUX Department of Dermatology, Hôtel Dieu, Place A. Ricordeau. 4403S Nantes cedex 01, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 129, Issue 1, 1 July 1993, Pages 77–81, https://doi.org/10.1111/j.1365-2133.1993.tb03316.x Published: 01 July 1993 Article history Accepted: 13 January 1993 Published: 01 July 1993
The association between lichen sclerosus and antigens of the HLA system
Authors: P. MARREN, J. JELL, F.M. CHARNOCK, M. BUNCE, K. WELSH, F. WOJNAROWSKA
Journal: British Journal of Dermatology (2006)

Although frequently linked clinically with autoimmune disease, no immunogenetic basis for lichen sclerosus has ever been established. In this study, we examined in detail the HLA antigens of 84 patients with histologically proven disease, compared with 357 controls. Patients with lichen sclerosus did not have the expected HLA A1, B8, DR3, DQ2 autoimmune profile. Instead, DQ7 was present in 39 of 78 (50%) of patients compared with 89 (25%) controls (P <0.001). In addition, 61 of 78 patients (78%) had either DQ7, DQ8 or DQ9 antigens, or a combination of these, compared with 142 (40%) controls (P < 0.01). Raised levels of DQ7 correspond to a glutamic acid residue at position 45 of the DQB1 locus. Proline amino acids at position 55 of this DQB1 locus could explain the raised levels of DQ7, 8 and 9, and exert a secondary effect. There is preliminary evidence that the immunogenetic profile of patients with this disease may affect disease expression with regard to site and extent of involvement.
Diagnosis of<i>Pneumocystis carinii</i>Pneumonitis by Means of Endobronchial Brush Biopsy
Authors: Lawrence H. Repsher, Gerhard Schröter, William S. Hammond
Journal: New England Journal of Medicine (1972)

PATIENTS with primary or iatrogenic immune deficiency states can have a clinical syndrome characterized by diffuse or patchy pneumonitis, nonproductive cough, fever, tachypnea and hypoxemia. Pneumocystis carinii is a cause of this syndrome but is difficult to diagnose since the organism cannot be cultured and is only rarely found in tracheal secretions.1 Percutaneous needle biopsy, aspiration needle biopsy, and open lung biopsy can demonstrate the organisms but carry a definite morbidity and mortality.2 Endobronchial brush biopsy by the method of Fennessey is a safe and well tolerated procedure even in very ill patients.3 , 4 The brush can easily obtain alveolar material . . .
Acyclovir in Lymphomatoid Papulosis and Mycosis Fungoides-Reply
Authors: Lionel Resnick
Journal: JAMA (1986)

In Reply.—  Burg and associates report two responders in 16 patients. Since we published our article, we have followed up a total of 30 patients with mycosis fungoides, treated with acyclovir. Of 12 patients treated by us, one had a complete response, three had partial responses, and eight had no response. Other investigators in the United States have reported to us an additional 18 cases, of which three had exhibited partial responses. Thus, in seven of 30 cases with mycosis fungoides, acyclovir therapy has yielded an apparent beneficial clinical effect.  Burg and associates report clinical improvement in two of five patients with lymphomatoid papulosis, another lymphoproliferative disorder thought to be related to mycosis fungoides that occasionally results in lymphoma. 1 It is of interest to note an apparent dose-response effect. The two patients who responded had the higher acyclovir blood levels. One of the two responders received intravenously administered acyclovir
No fleas on me
Authors: T. Dalrymple
Journal: BMJ (2009)

Whenever there are mosquitoes about they seem to bite my wife and not me. It was the same with my brother. Whether this is because some people do not react to bites and therefore do not notice them or because some people are less attractive to mosquitoes I have not been able easily to discover; but Samuel Pepys, in his diary, notes a cognate phenomenon with regard to fleas.

On 23 April 1662 he travelled with Timothy Clarke, the king’s physician and founding fellow of the Royal Society, to Portsmouth, where they slept overnight in the same bed at the house of a surgeon called Wiards. Pepys concluded, no …
HYSTERICAL APHONIA, OR PARALYSIS OF THE LATERAL CRICOARYTENOID MUSCLES.Read in the Section of Laryngology and Otology at the Forty-first Annual Meeting of the American Medical Association, Nashville, Tenn., May, 1890.
Authors: E. FLETCHER INGALS
Journal: JAMA (1890)

One of the most interesting manifestations of the group of symptoms which make up what is termed hysteria, is paralysis of the adductor muscles of the vocal cords. It is a singular fact in accordance with what might be termed a conservative law of pathological selection, that in nerve trunks not larger than a small knitting needle, in this disease only those fibres are involved which supply the adductor muscles, while adjoining fibres supplying the abductor muscles are not implicated. This is peculiarly fortunate, for otherwise this merely annoying affection would often become a fatal malady. This affection usually occurs in young women, but is sometimes observed later in life and has been met with even in children. Although termed hysterical, cases are not very infrequent among men. As the name implies, the disease is usually associated with some form of hysteria, but it sometimes
Treatment of Substance Abuse in Military Hampered by “Old-fashioned” Approach
Authors: Bridget M. Kuehn
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Esophageal self-expanding metallic stent (SEMS) migration: it's a topsy-turvy world
Authors: E. Toussaint, M. Zalcman, J. Devière, O. Le Moine, M. Arvanitakis
Journal: Endoscopy (2012)

A 47-year-old woman underwent endoscopic treatment of a fistula following sleeve gastrectomy, performed 3 weeks earlier. A partially covered self-expandable metallic stent (SEMS) was inserted (15 cm, 18 – 23 mm Ultraflex, Boston Scientific, Natick, Massachusetts, USA). At 1 month follow-up she was symptom-free. Radiographic examination and computed tomography ([Fig. 1]) showed that the stent had partially migrated distally, and there was no collection. The patient became aphagic 6 days before her scheduled admission for retrieval of the partially covered SEMS. Endoscopy revealed that the stent had bent and "re-migrated" proximally, into the mid-esophagus, thus causing complete obstruction ([Fig. 2]). The stent was retrieved using rat-tooth forceps, and the patient was discharged the next day. She remains symptom-free.
The National Emphysema Treatment Trial (NETT)
Authors: Gerard J. Criner, Francis Cordova, Alice L. Sternberg, Fernando J. Martinez
Journal: American Journal of Respiratory and Critical Care Medicine (2011)

Section:ChooseTop of pageAbstract <<NETT Patient PopulationPathobiology of COPDGenetics of COPDImportance of Hyperinflat...Pulmonary Hemodynamics in...Physiological Measurement...Differences in the Presen...Risk for Mortality in Emp...Medical Therapy in Emphys...SummaryReferencesCITING ARTICLES
Glycaemic control improves perfusion recovery and VEGFR2 protein expression in diabetic mice following experimental PAD
Authors: Ayotunde O. Dokun, Lingdan Chen, Swapnil S. Lanjewar, Robert John Lye, Brian H. Annex
Journal: Cardiovascular Research (2014)

AimsDiabetes mellitus (DM) is associated with poor clinical outcomes in humans with peripheral arterial disease (PAD) and in pre-clinical models of PAD, but the effects of glycaemic control are poorly understood. We investigated the effect of glycaemic control on experimental PAD in mice with Type 1 DM and explored the effects of hyperglycaemia on vascular endothelial growth factor receptor 2 (VEGFR2) expression in ischaemia.
Quantifying Lymphocytes in Bronchoalveolar Lavage Fluid
Authors: Gregory C. Kane
Journal: Annals of Internal Medicine (1993)

Letters15 November 1993Quantifying Lymphocytes in Bronchoalveolar Lavage FluidGregory C. Kane, MDGregory C. Kane, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-10-199311150-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with great interest the recent article by Roberts and colleagues [1]. Of concern was the marked lymphocytosis present in lavage fluid before irradiation, as well as the slightly elevated cell count. The patients had an increased total cell count (22.4 106 cells with 61% macrophages, 34.5% lymphocytes, and 4% neutrophils). Such an increase in cellularity and prominent lymphocytosis represents a markedly abnormal baseline. In studies reviewed by the Bronchoalveolar Lavage Cooperative Group Steering Committee, total cell counts were generally less than 16 106 cells in nonsmoking patients when the lavage volume was 150 mL. The ...References1. Roberts CM, Foulcher E, Zaunders JJ, Bryant DH, Freund J, Cairns D, et al. Radiation pneumonitis: a possible lymphocyte-mediated hypersensitivity reaction. Ann Intern Med. 1993; 118:696-700. Google Scholar2. BAL Cooperative Group Steering Committee. Am Rev Respir Dis. 1990; 141:S169-202. Google Scholar3. White DA, Rankin JA, Stover DE, Gellene RA, Gupta S. Methotrexate pneumonitis. Am Rev Respir Dis. 1989; 139:18-21. Google Scholar4. Fink JN. Hypersensitivity pneumonitis. J Allergy Clin Immunol. 1984; 74:1-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1993Volume 119, Issue 10Page: 1050-1051KeywordsAntigensBronchoalveolar lavageChemotherapeutic agentsChemotherapyHypersensitivityLymphocytesMethotrexateNeutrophilsPneumonitisToxicity ePublished: 15 August 2000 Issue Published: 15 November 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Traitement endoscopique des sténoses biliaires anastomotiques post transplantation hépatique par prothèses métalliques expansives couvertes
Authors: A Chryssostalis, M Gaudric, O Scatton, O Soubrane, PP Massault, F Conti, Y Calmus, S Chaussade, F Prat
Journal: Endoscopy (2008)

Objectif: Le but de ce travail était d'évaluer prospectivement la faisabilité de la mise en place et de l'ablation endoscopique de prothèses métalliques expansives couvertes (PMEC) dans les sténoses biliaires anastomotiques après transplantation hépatique.
Mutagenicity studies of vinyl chloride.
Authors: J D Fabricant, M S Legator
Journal: Environmental Health Perspectives (1981)

Mutagenicity studies in both man and in test organisms clearly demonstrate positive mutagenic activity of vinyl chloride. In terms of the mutagenicity studies using a variety of in vitro procedures covering both eukaryotes and prokaryotes, positive effects were found. Cytogenetic in vivo studies in animals and in humans indicate not only somatic mutations, but also germinal effects with this chemical.
Association of 5q− and refractory anemia
Authors: Sara Kaffe, Lillian Y. F. Hsu, Ronald Hoffman, Kurt Hirschhorn
Journal: American Journal of Hematology (1978)

Abstract The association of refractory anemia with partial deletion of the long arm of one No. 5 chromosome (5q−) has been reported in six patients within the last two years. We wish to report an additional patient with refractory anemia and an acquired chromosomal deletion, del(5)(q15), in a direct bone‐marrow preparation. The specificity of this deletion for refractory anemia is discussed. It remains to be seen whether patients with refractory anemia and 5q− tend to develop acute leukemia, as has been recently suggested.
SANITARY INSPECTION OF DAIRIES AND DISTRIBUTING DEPOTS.
Authors: E. H. WEBSTER
Journal: JAMA (1907)

A systematic sanitary inspection of dairy farms and milk-distributing depots are anything but ideal; they are, in fact, about as bad as it is possible to conceive. Stables are poorly lighted, many having no windows whatever, and ventilation is left to care for itself. Little attention is paid to floors, ceilings, walks, or stable yards. Swine, horses and poultry are often found in the same barn with the cows. Manure is not removed, or, when removed, is thrown through an opening in the wall or just outside the door, frequently near the milk room. The necessary appliances for sterilizing and cooling in milk room are often lacking, making it impossible properly to wash and sterilize pails, cans, bottles and other appliances, or to properly cool and hold at a low temperature the milk before delivery. Milk dealers, as a rule, have more respect for sanitation and have better appliances than