Mediastinal Germ Cell Tumor and Acute Megakaryoblastic Leukemia
Authors: Alicia Domingo, Vicente Romagosa, Manuel Callis, Pilar Vivancos, Nieves Guionnet, Jesus Soler
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 September 1989Mediastinal Germ Cell Tumor and Acute Megakaryoblastic LeukemiaAlicia Domingo, MD, Vicente Romagosa, MD, Manuel Callis, MD, Pilar Vivancos, MD, Nieves Guionnet, MD, Jesus Soler, MDAlicia Domingo, MDSearch for more papers by this author, Vicente Romagosa, MDSearch for more papers by this author, Manuel Callis, MDSearch for more papers by this author, Pilar Vivancos, MDSearch for more papers by this author, Nieves Guionnet, MDSearch for more papers by this author, Jesus Soler, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-6-539 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Mediastinal germ cell tumors are considered variants of testicular germ cell neoplasms, which occur infrequently in humans (1). The association of mediastinal germ cell tumors with different types of hematologic malignancies has been described in at least 20 patients (1-4). We report the case of a man who had acute megakaryoblastic leukemia (M7) with simultaneous occurrence of a primary mediastinal germ cell tumor.A 31-year-old man presented with a 2-week history of a temperature of 39 °C and hemorrhagic syndrome (ecchymosis and purpura). The rest of the physical examination was normal including the examination of the testes....References1. NicholsHoffmanEinhornWilliamsWheleerGarnick CRLSLM. Hematologic malignancies associated with primary mediastinal germ cell tumor. Ann Intern Med. 1985;102:603-9. LinkGoogle Scholar2. DementEgglestonSpivak SJJ. Association between mediastinal germ cell tumors and hematologic malignancies. Report of two cases and review of the literature. Am J Surg Path. 1985;9:23-30. CrossrefMedlineGoogle Scholar3. NicholsHoffmanGiantGoheen CRMM. Malignant disorders of megakaryocytes associated with primary mediastinal germ cell tumors. Prog Clin Biol Res. 1986;215:347-53. MedlineGoogle Scholar4. LandanyiRoy MI. Mediastinal germ cell tumors and histiocytosis. Hum Pathol. 1988;19:586-90. CrossrefMedlineGoogle Scholar5. LarsenEvansShepherdPhillipsBaileyMessner MWFJDH. Acute lymphoblastic leukemia. Possible origin from a mediastinal germ cell tumor. Cancer. 1984;53:441-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGerm Cell TumorsNon-seminomatous mediastinal germ cell tumor and acute megakaryoblastic leukemiaUncommon Pediatric Tumors of the ThoraxAcute megakaryocytic leukemia: What have we learnedAcquired isochromosome 12p, somatic TP53 and PTEN mutations, and a germline ATM variant in an adolescent male with concurrent acute megakaryoblastic leukemia and mediastinal germ cell tumorUncommon Pediatric Tumors of the ThoraxPrimary Mediastinal Germ Cell Tumor Evolving Into an Extramedullary Acute Megakaryoblastic Leukemia Causing Cord CompressionHematologic Manifestations of Trisomy 21Acute megakaryoblastic leukemia: experience of GIMEMA trialsMediastinal Non-seminomatous Germ Cell Tumours: Their Association with Non-germ Cell MalignanciesAcute Myeloblastic Leukemia Associated with Mediastinal Nonseminomatous Germ Cell Tumors. Report on two CasesThe clonal nature of mediastinal germ cell tumors and acute myelogenous leukemiaMalignant Hematologic Disorders Arising from Mediastinal Germ Cell Tumors. A Review of Clinical and Biologic FeaturesHematologic Neoplasia Associated with Primary Mediastinal Germ-Cell Tumors 15 September 1989Volume 111, Issue 6Page: 539-539KeywordsGerm cellsHematologic malignanciesTemperatureTestes Issue Published: 15 September 1989 PDF DownloadLoading ...