tbuckley/cabot-search huggingface dataset:
Abstract 5645: Growth inhibitory activity of ethanol extracts of Chinese and Brazilian propolis in human colon carcinoma cell lines
Authors: Ichiro Yoshida, Makoto Nakashima, Masashi Ishihara, Takamitsu Morioka, Yoshinori Itoh, Naoki Yoshimi, Masumi Suzui
Journal: Cancer Research (2010)

Abstract Propolis is a natural product derived from plant resins collected by honeybees, and has been used globally as a folk medicine for centuries. More than 300 bio-active compounds have been identified from bee propolis. In the current study, we examined whether the ethanol extracts of Chinese and Brazilian propolis exert anticancer activities in four human colon carcinoma cell lines, CaCo2, HCT116, HT29 and SW480. Propolis samples were extracted with ethanol, and the crude extracts were dissolved in dimethylsulfoxide and used for the following experiments. We also examined the effects of the ethanol extract of Chinese propolis on cell proliferation, cell cycle progression, apoptosis, and the levels of expression of cell cycle control molecules in the HCT116 and HT29 cell lines. In the HCT116, HT29 and SW480 cell lines, the extracts of both Chinese and Brazilian propolis caused a marked dose-dependent growth inhibition, with IC50 values in the range of 4-41 μg/ml. In the FHC normal human colonic epithelial cell line, the extract of Chinese propolis failed to cause a marked growth inhibition, the growth inhibition rate was about 20%, whereas it was about 90% in the HCT116 and HT29 cell lines. In the HCT116 cell line, at concentrations of 10 and 20 μg/ml the extract of Chinese propolis caused a marked increase in sub-G1 fraction of cells in a dose-dependent fashion. The propolis extract (20 μg/ml) caused a significant increase of cells in sub-G1 and this increase was associated with a concomitant relative decrease of cells in the G1, S and G2-M phases of the cell cycle, indicating that Chinese propolis extract induced apoptosis in the HCT116 cell line. In addition, Chinese propolis extract caused a dose-dependent increase in the cellular mRNA levels of p21CIP1 and p53 in the HCT116 cell line. These findings indicate that the ethanol extracts of propolis contain components that may have anticancer activity. Thus, propolis and related products may provide a novel approach to the chemoprevention and/or chemotherapy of human colon carcinoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5645.
Body mass and prostatic cancer: a prospective study.
Authors: R. K. Severson, J. S. Grove, A. M. Nomura, G. N. Stemmermann
Journal: BMJ (1988)

Previous studies have suggested that increased body mass is associated with an increased risk of prostatic cancer, but these studies have been limited by the fact that they were based on a few simple measurements such as height and weight. Similar results were found in a prospective study of the incidence of prostatic cancer in a cohort of Japanese men born in 1900-19 and living in Hawaii. Further evaluation of the extensive anthropomorphic measurements made in this cohort suggested that the association between measures of body mass and prostatic cancer might be accounted for more by lean tissue than by fat tissue. There was a significant positive association of the risk of prostatic cancer with area of muscle in the arm but not with area of fat in the arm. Further research is needed on the biological mechanisms of carcinogenesis that may be related to both lean and fat tissue and the development of prostatic cancer.
Reappraisal of clinical features of diverticular disease of the colon
Authors: T. G. Parks
Journal: BMJ (1969)

In patients with diverticular disease of the colon factors which indicate a worse prognosis include widespread abdominal pain, nausea and vomiting, disturbed bowel habit, a palpable abdominal mass, abdominal distension, and any of the inflammatory complications. While radiology is of prime importance in the initial diagnosis, it is often impossible to differentiate between diverticulosis and diverticulitis. A more accurate distinction can be made by assessing all the available clinical, radiological, and pathological data, but again there are limitations and inaccuracies. The use of the term "diverticular disease" is preferable.
Monoclonal-Antibody Therapy in Systemic Vasculitis
Authors: Peter W. Mathieson, Stephen P. Cobbold, Geoffrey Hale, Michael R. Clark, David B.G. Oliveira, C. Martin Lockwood, Herman Waldmann
Journal: New England Journal of Medicine (1990)

MONOCLONAL antibodies are potentially useful therapeutic agents in a variety of immunologically mediated diseases, offering the theoretical advantage of selective attack on cells implicated in the immunopathogenesis of these disorders. Antibodies to surface markers on lymphocytes, particularly T cells, have already demonstrated efficacy both in animal models and in clinical allograft rejection.1 2 3 For this purpose, monoclonal antibodies can be used either to block vital receptors for antigen, adhesion, or growth factors or to block target cells by harnessing the various natural effector systems (complement and accessory cells) that are activated by the Fc regions of cell-bound antibodies. The optimal use . . .
Plasma viscosity in giant cell arteritis as a predictor of disease activity.
Authors: M Gudmundsson, E Nordborg, B.A Bengtsson, A Bjelle
Journal: Annals of the Rheumatic Diseases (1993)

Thirty one patients with giant cell arteritis (GCA) receiving standardised prednisolone treatment were followed up for one year with analyses of plasma viscosity, erythrocyte sedimentation rate (ESR), C reactive protein (CRP), and fibrinogen concentration. On the day of diagnosis all patients had an increased plasma viscosity and ESR, whereas the concentration of CRP was normal in three patients and fibrinogen concentration and haptoglobin values were normal in one patient. IgG levels were increased in two patients. Plasma viscosity correlated significantly with the ESR, IgG level, and fibrinogen concentration. Laboratory variables in subgroups of patients with GCA proved by biopsy were not different from the whole group of patients with GCA. The follow up showed that CRP normalised faster than the ESR, plasma viscosity, and fibrinogen concentration. Plasma viscosity and the ESR paralleled clinical findings more closely and predicted flare ups better than the other variables. Plasma viscosity had advantages over the ESR for predicting flare ups and in the clinical monitoring of treatment with glucocorticoids.
P732 PREDICTIVE VALUE OF THE INTERFERON-LAMBDA 4 GENE (IFN-L4) FOR DIRECT-/ANTIVIRAL TREATMENT IN HEPATITIS C VIRUS INFECTED PATIENTS WITH GENOTYPES 1, 2, 3, AND 4
Authors: S. Susser, C.M. Lange, N. Hamdi, T. Berg, D. Perner, S. Zeuzem, C. Sarrazin
Journal: Journal of Hepatology (2014)
Supplementation with Folic Acid during Methotrexate Therapy for Rheumatoid Arthritis: A Double-Blind, Placebo-Controlled Trial
Authors: Sarah L. Morgan
Journal: Annals of Internal Medicine (1994)

Objective: To determine the effect of two different weekly doses of folic acid on the toxicity and efficacy of low-dose methotrexate therapy for rheumatoid arthritis. Design: Randomized, double-blind, placebo-controlled study. Patients: 79 persons between 19 and 78 years of age who fulfilled the American Rheumatism Association's criteria for rheumatoid arthritis. Intervention: Participants were randomly assigned to visually identical placebo or to 5 mg or 27.5 mg of folic acid each week. Measurements: Duration, intensity, and clinical severity of toxic events; efficacy (indices of joint tenderness and swelling and grip strength); plasma and erythrocyte folate levels; and other laboratory variables. Results: Folic acid supplementation at either dose did not affect the efficacy of methotrexate therapy as judged by joint indices and patient and physician assessments of disease. Patients given folic acid supplements had lower toxicity scores than did participants given placebo (P ≤ 0.001). Low blood folate levels and increased mean corpuscular volumes were associated with substantial methotrexate toxicity, whereas daily dietary intakes of more than 900 nmol (400 µg) of folic acid were associated with little methotrexate toxicity. Conclusions: Folic acid, an inexpensive vitamin, is safe in a broad range of doses and protects patients with rheumatoid arthritis who are taking methotrexate from toxicity while preserving the efficacy of methotrexate.
<i>Podoplanin</i> Is a Novel Fos Target Gene in Skin Carcinogenesis
Authors: Moritz Durchdewald, Juan Guinea-Viniegra, Daniel Haag, Astrid Riehl, Peter Lichter, Meinhard Hahn, Erwin F. Wagner, Peter Angel, Jochen Hess
Journal: Cancer Research (2008)

Abstract Expression and function of the oncogenic transcription factor activator protein (AP-1; mainly composed of Jun and Fos proteins) is required for neoplastic transformation of keratinocytes in vitro and tumor promotion as well as malignant progression in vivo. Here, we describe the identification of 372 differentially expressed genes comparing skin tumor samples of K5-SOS-F transgenic mice (Fosf/f SOS+) with samples derived from animals with a specific deletion of c-Fos in keratinocytes (FosΔep SOS+). Fos-dependent transcription of selected genes was confirmed by quantitative real-time PCR analysis using tumor samples and mouse back skin treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). One of the most differentially expressed genes encodes the small mucin–like glycoprotein Podoplanin (Pdpn), whose expression correlates with malignant progression in mouse tumor model systems and human cancer. We found Pdpn and Fos expression in chemically induced mouse skin tumors, and detailed analysis of the Pdpn gene promoter revealed impaired activity in Fos-deficient mouse embryonic fibroblasts, which could be restored by ectopic Fos expression. Direct Fos protein binding to the Pdpn promoter was shown by chromatin immunoprecipitation and a TPA-induced complex at a TPA-responsive element–like motif in the proximal promoter was identified by electrophoretic mobility shift assays. In summary, we could define a Fos-dependent genetic program in a well-established model of skin tumors. Systematic analysis of these novel target genes will guide us in elucidating the molecular mechanisms of AP-1–regulated pathways that are critically implicated in neoplastic transformation and/or malignant progression. [Cancer Res 2008;68(17):6877–83]
Scottish private hospital calls in receivers
Authors: B Christie
Journal: BMJ (1994)

Receivers have been called in to a pounds sterling 180m private hospital run by Americans in Scotland only four months after it opened officially. The Health Care International hospital, founded by two former Harvard professors, was built to treat patients from overseas but has failed to attract them in anything like the numbers predicted.

A banking consortium, which has invested almost pounds sterling 100m in the project, decided last week to call in the receivers after failing to agree a rescue plan that would have required further investment in the hospital. The British government has already spent pounds sterling 30m of taxpayers' money in industrial aid to attract the hospital to Scotland. Patients are continuing to be treated as the receivers try to find a buyer for the hospital, which was built at Clydebank on the outskirts of Glasgow.

The idea …
A major role for VCAM-1, but not ICAM-1, in early atherosclerosis
Authors: Myron I. Cybulsky, Kaeko Iiyama, Hongmei Li, Suning Zhu, Mian Chen, Motoi Iiyama, Vannessa Davis, Jose-Carlos Gutierrez-Ramos, Philip W. Connelly, David S. Milstone
Journal: Journal of Clinical Investigation (2001)

VCAM-1 and ICAM-1 are endothelial adhesion molecules of the Ig gene superfamily that may participate in atherogenesis by promoting monocyte accumulation in the arterial intima. Both are expressed in regions predisposed to atherosclerosis and at the periphery of established lesions, while ICAM-1 is also expressed more broadly. To evaluate functions of VCAM-1 in chronic disease, we disrupted its fourth Ig domain, producing the murine Vcam1D4D allele. VCAM-1D4D mRNA and protein were reduced to 2–8% of wild-type allele (Vcam1+) levels but were sufficient to partially rescue the lethal phenotype of VCAM-1–null embryos. After crossing into the LDL receptor–null background, Vcam1+/+ and Vcam1D4D/D4D paired littermates were generated from heterozygous intercrosses and fed a cholesterol-enriched diet for 8 weeks. The area of early atherosclerotic lesions in the aorta, quantified by en face oil red O staining, was reduced significantly in Vcam1D4D/D4D mice, although cholesterol levels, lipoprotein profiles, and numbers of circulating leukocytes were comparable to wild-type. In contrast, deficiency of ICAM-1 either alone or in combination with VCAM-1 deficiency did not alter nascent lesion formation. Therefore, although expression of both VCAM-1 and ICAM-1 is upregulated in atherosclerotic lesions, our data indicate that VCAM-1 plays a dominant role in the initiation of atherosclerosis.
Effect of increasing doses of beta agonists on spirometric parameters, exercise capacity, and quality of life in patients with chronic airflow limitation.
Authors: R Jaeschke, G H Guyatt, A Willan, D Cook, S Harper, J Morris, H Ramsdale, R Haddon, M Newhouse
Journal: Thorax (1994)

BACKGROUND--A study was undertaken to determine the impact of different doses of inhaled terbutaline on peak flow rates, spirometric parameters, functional exercise capacity, and quality of life in patients with chronic airflow limitation. METHODS--A double blind, randomised, placebo controlled, multiple crossover trial was conducted with treatment periods of one week. Patients with a clinical diagnosis of chronic airflow limitation and FEV1 below 70% predicted after administration of bronchodilator were recruited from secondary care respiratory practices, and the effect of 500, 1000, and 1500 micrograms inhaled terbutaline four times daily on spirometric parameters (FEV1, FVC), maximum inspiratory pressures, six minute walking distance, and health-related quality of life (Chronic Respiratory Disease Questionnaire, Quality of Well Being, Standard Gamble) was measured. RESULTS--Twenty five patients completed the trial. Peak flow rates and FEV1 showed statistically significant but clinically trivial improvement on the higher drug doses. Results of maximum inspiratory pressure measurements, walk test distance, and quality of life measures showed minimal differences on the different dosages, and none of the differences approached conventional statistical significance. CONCLUSIONS--Regular use of beta agonists in doses higher than two puffs four times a day is very unlikely to provide additional functional or symptomatic benefit to patients with chronic airflow limitation.
Stress fracture of base of the acromion
Authors: N Roy
Journal: Annals of the Rheumatic Diseases (2002)

Fractures of the scapula occur infrequently, with a fracture of the acromion being an even rarer entity. Acromial fractures constitute 9% of fractures of the scapula, which amounts to 3–5% of shoulder girdle injuries.1 Fractures of the acromion are generally secondary to trauma, with only a few cases of stress fracture having been reported.2–5

Reports published in English have described stress fractures of the acromion at the base of the acromion extending to the spine of the scapula,2 neck of the acromion,3 medial aspect of the acromion,4 and the base of the acromion only.5 These cases occurred in young to middle aged patients and were associated with a single violent muscle contraction or repetitive subcritical load to the shoulder. We present a case of an atraumatic osteoporotic stress fracture at the base of the acromion associated with chronic rotator cuff tear arthropathy.

The patient, an 82 …
Governmentally Operated Health and Medical Programs
Authors: Ben Freedman
Journal: JAMA (1960)

Medically directed agencies, particularly health departments, are the most suitable for operating official health programs, because they have the longest experience and most comprehensive objectives in medical administration. No other type of official agency has the diversity of professional health personnel and organizational setup to operate an integrated clinical, home, and field program. When health programs are dispersed piecemeal among nonmedically directed agencies, the result is fragmentation and deterioration of services, duplication and rivalry of administrative organizations, and depreciation of the physician in the scheme of community health services. The alliance of health departments and organized medicine is essential to regaining medical leadership in community health programs.
Renal abnormalities in rheumatoid arthritis.
Authors: R.J Bulger, L.A Healey, P Polinsky
Journal: Annals of the Rheumatic Diseases (1968)

The subject of renal disease in rheumatoid arthritis has recently been reviewed (Lancet, 1966), and the usual opinion that renal lesions are uncommon in rheumatoid arthritis has been disputed by studies such as that of Lawson and McLean (1966) who found significant kidney disease in 44 of 61 patients at autopsy examination.Various types of renal abnormalities have been described.Vascular lesions similar to those in systemic lupus erythematosus and polyarteritis are unusual in rheumatoid arthritis.Amyloidosis affect- ing the kidney is a complication of long-standing rheumatoid arthritis and has been reported in 15 to 20 per cent. of most series.The association between interstitial nephritis, papillary necrosis, and excessive use of analgesics, particularly phenacetin, has directed attention to the possibility that such renal lesions may occur in patients with rheumatoid arthritis, many of whom take large amounts of these drugs for prolonged periods.
Cystic Lesion of Humerus
Authors: Charles K. Jenkins
Journal: JAMA (1968)

Dr. Richard M. Heller: This was the first Massachusetts General Hospital admission for this 54-year-old white male tool-grinder. His chief complaint was pain of four weeks' duration in the left shoulder. The pain was accentuated by abduction and was worse at night. There had been no fever, weight loss, or other symptoms. The patient fractured his left humerus at age 16. Physical examination of the left arm revealed tenderness over the greater tuberosity and proximal part of the humerus. There was no erythema, no increased temperature, and no increase in size of the left arm. Active abduction was limited to 90° Passive range of motion was unlimited. Findings from laboratory investigations were all normal. These included hematocrit reading, white blood cell count, differential count, liver function tests, and calcium, phosphorus, alkaline phosphatase, fasting blood sugar, and blood urea nitrogen values. Roentgenograms of the arm were obtained (Figure). Roentgenograms of the
False suspicion of coronary heart disease: a 7 year follow-up study of 36 apparently healthy middle-aged men.
Authors: J Erikssen, J Dale, K Rootwelt, E Myhre
Journal: Circulation (1983)

Latent coronary heart disease was suspected in 115 of 2014 apparently healthy middle-aged men after a baseline cardiovascular survey. One hundred five of these men underwent angiography and 36 were found to have normal coronary arteries (group 1). A 7 year follow-up survey revealed that: (1) three had died of sudden cardiac death, (2) four had received a diagnosis of cardiomyopathy, (3) one had developed aortic dilatation/aortic regurgitation since the baseline survey, (4) they all had a significantly more rapid decline in their physical performance and maximal heart rate levels from the time of the baseline survey to follow-up than did randomly selected normal controls (group 2), and (5) thallium study results were normal in both groups (27 and 26 patients), but technetium ventriculography revealed a subnormal increase in ejection fraction during exercise (less than 5% units) in 14 of 27 group 1 subjects and in 4 of 26 group 2 subjects. Thus, incipient heart disease may be present in subjects in whom coronary angiographic examination has removed a previous suspicion of coronary heart disease.
Goiter and Hypothyroidism.
Authors: Carl E. Cassidy
Journal: Annals of Internal Medicine (1968)

s1 May 1968Goiter and Hypothyroidism.Carl E. Cassidy, M.D., Richard L. Eddy, M.D., Edwin B. Astwood, M.D., F.A.C.P.Carl E. Cassidy, M.D.Search for more papers by this author, Richard L. Eddy, M.D.Search for more papers by this author, Edwin B. Astwood, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1143_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNontoxic goiter, a compensatory phenomenon, reflects a defect in the synthesis of thyroxine. The deficiency stimulates secretion of thyroid-stimulating hormone, enlargement of the thyroid ensues, the daily requirement of thyroxine is met, and the only abnormality that results is the "simple" goiter. We suspected that the compensation should not always be so complete and that goiter and hypothyroidism should sometimes coexist. The suspicion was confirmed by finding 234 patients during a 13-year period.The frequency of the signs and symptoms was tabulated. Both the protein-bound iodine (PBI) and the 24-hr131I uptake by the thyroid were carried out in 200... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by2,2?-Diphenyl-?3,3?-bi-3H-indole-1,1?-dioxide: Competitive demethylation and redox reactions 1 May 1968Volume 68, Issue 5Page: 1143-1144KeywordsHypothyroidismProteinsSigns and symptomsThyroidThyroid-stimulating hormoneThyroxine ePublished: 1 December 2008 Issue Published: 1 May 1968 PDF downloadLoading ...
Central Role of PKCβ in Neointimal Expansion Triggered by Acute Arterial Injury
Authors: Martin Andrassy, Dmitry Belov, Evis Harja, Yu Shan Zou, Michael Leitges, Hugo A. Katus, Peter P. Nawroth, Shi Du Yan, Ann Marie Schmidt, Shi-Fang Yan
Journal: Circulation Research (2005)

We tested the hypothesis that PKCbeta contributes to vascular smooth muscle cell (SMC) migration and proliferation; processes central to the pathogenesis of restenosis consequent to vascular injury. Homozygous PKCbeta null (-/-) mice or wild-type mice fed the PKCbeta inhibitor, ruboxistaurin, displayed significantly decreased neointimal expansion in response to acute femoral artery endothelial denudation injury compared with controls. In vivo and in vitro analyses demonstrated that PKCbetaII is critically linked to SMC activation, at least in part via regulation of ERK1/2 MAP kinase and early growth response-1. These data highlight novel roles for PKCbeta in the SMC response to acute arterial injury and suggest that blockade of PKCbeta may represent a therapeutic strategy to limit restenosis.