tbuckley/cabot-search huggingface dataset:
Abstract 1229: Fibroblast growth factor signaling in ovarian cancer
Authors: Manuel Brantner, Renate Wagner, Michael Grusch, Walter Berger, Klaus Holzmann, Brigitte Marian, Thomas W. Grunt
Journal: Cancer Research (2012)

Abstract Epithelial ovarian cancer (OC) is a rapidly progressive, highly lethal disease. It is the fifth leading cause of cancer-related death among women. Over the last decades, there has been only modest improvement in the treatment of OC. Nevertheless, recent clinical trials with inhibitors of transmembrane receptor tyrosine kinases such as fibroblast growth factor (FGF) receptors (FGFRs) yielded some promising results in OC. FGFRs are involved in malignant transformation, angiogenesis and chemoresistance. Inhibition of FGFR-dependent signaling can overcome resistance to standard therapies. Thus, FGFRs represent potential targets for cancer therapy. Unfortunately, however, the biological and therapeutic relevance of the FGF-FGFR system has not been elucidated yet in OC. The aim of this study was to characterize the FGF-FGFR system, its influence on malignancy-related cell properties and its potential role as a druggable signaling pathway in OC cells. Reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed that expression of FGFs and FGFRs, leading to autocrine signaling loops with a strong mitogenic potential, is a common event in OC. Immunoblotting proved that the FGF signaling system is functionally active in these cells. Conditioned growth medium was able to induce phosphorylation of ERK1/2. Moreover, recombinant FGF-2 significantly elevated the growth rate in approximately 50% of the OC cell lines as demonstrated by formazan dye assay, whereas FGF-1 markedly induced migration in 66% of the cell lines. The dependency of OC cells on FGFR signaling was further evaluated by growth inhibition assays using the two small molecular FGFR inhibitors PD173074 and dovitinib (TKI-258, CHIR-258). A-2780 cells were found to be extremely sensitive to FGFR inhibition, while HEY and SKOV-3 cells showed moderate sensitivity. In contrast, OVCAR-3 cells were not inhibited by these compounds. Together, our data suggest that FGFR inhibitors reveal anticancer activity in a significant proportion of OC cells even as single drugs. Thus, combination of conventional cytotoxic intervention with blockade of the FGF-FGFR system might represent a promising future strategy for the treatment of OC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1229. doi:1538-7445.AM2012-1229
Genome Provides Clues on Addiction
Authors: Bridget M. Kuehn
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Managing patients who refuse blood transfusions: an ethical dilemma: Major trauma in two patients refusing blood transfusion
Authors: S Finfer, S Howell, J Miller, K Willett, J Wilson-MacDonald
Journal: BMJ (1994)

Patients who refuse blood transfusions after severe blood loss have a poor prognosis but survival is possible. Below Simon Finfer and colleagues describe how they managed two patients who presented after a car crash. We asked an ethical expert, a former pathologist who is a Jehovah's Witness, and a lawyer to comment on the issues that these cases raised.

Patients with severe injuries who refuse blood transfusion present complex medical, legal, and moral problems. In many cases treatment may seem futile but occasionally patients will survive despite severe haemodilution. We report the cases of two men who were badly injured when their car was impaled on a motorway crash barrier.

The front seat passenger was a 29 year old man. He had an open fracture of the left femur, laceration of the left femoral artery, and a closed fracture …
The Flowers of Evil and Paris Spleen
Authors: Gerald Weissmann
Journal: JAMA (1992)

Poets are more likely to be patients than doctors, and no poets displayed more florid pathology than the three Frenchmen who made poetry modern: Baudelaire, Verlaine, and Rimbaud. They carried among them more diagnoses than a wardful of my patients at Bellevue. Addicted to hashish and absinthe, they suffered from tertiary syphilis, tuberculosis, or both, and rode the roller coaster of bipolar mood disorders. They experienced the expected complications of these ills, which ranged from acute delirium to terminal paresis. In moments between, they simply showed sociopathic behavior: Verlaine shot Rimbaud in a lover's quarrel, and Baudelaire stalked the barricades with a musket calling for the death of his stepfather. They supported themselves by sponging off despised parents. Unlike my patients at Bellevue, however, these men wrote the most ravishing verse of their age. And Dr William H. Crosby's magisterial new translation of Baudelaire's poetry makes it clear that the
881-6 Effect of attenuation on intravascular thrombus dissolution using transcutaneous ultrasound and intravenous microbubbles
Authors: Thomas R Porter, Jeane Mike Tsutsui, Jason M Johanning, B.Timothy Baxter, John Lof, Terry Matsunaga, Reena Zutshi, Evan Unger, Feng Xie
Journal: Journal of the American College of Cardiology (2004)
Interleukin-27 inhibits pediatric B-acute lymphoblastic leukemia cell spreading in a preclinical model
Authors: S Canale, C Cocco, C Frasson, E Seganfreddo, E Di Carlo, E Ognio, C Sorrentino, D Ribatti, A Zorzoli, G Basso, C Dufour, I Airoldi
Journal: Leukemia (2011)
Peer review of consultations in primary care: the use of audiovisual recordings.
Authors: J E Verby, P Holden, R H Davis
Journal: BMJ (1979)

A rating scale was designed to measure performance in interviewing techniques in primary care. Peer review of audiovisual recordings of their consultations showed that a group of experienced general practitioners achieved significantly higher scores on the rating scale compared with a group of similarly experienced general practitioners who did not observe their recordings. The higher scores were obtained at the expense of longer consultations. The traditional five-minute appointment system in general practice needs to be reconsidered if an improved interviewing technique results in a more favourable outcome.
Activated c-Src (Y215) kinase expression predicts for early relapse on tamoxifen in human breast cancer.
Authors: SM Tovey, BA Tan, J Campbell, B Elsberger, V Brunton, E Mallon, TC Cooke, J Edwards
Journal: Cancer Research (2009)

Abstract Abstract #3025 Recent studies have demonstrated activation of the non-receptor tyrosine kinase c-Src in tamoxifen resistant breast cancer cell lines, which when treated with Src inhibitors demonstrate a reduction in motility and invasiveness. However, there are little published translational studies confirming a role for c-Src in tamoxifen resistance in vivo. We aim to determine if activated c-Src expression correlates clinically with increased recurrence on tamoxifen.&amp;#x2028; Methods&amp;#x2028; Tissue microarrays were constructed from a patient cohort of 402 Tamoxifen treated ER positive patients. Immunohistochemistry was performed using commercially available antibodies to Total Src as well as to activated (phosphorylated) c-Src at 2 sites (Y416 and Y215) (pSrc416 and pSrc215 respectively). Expression was assessed by 2 independent scorers (weighted histoscore method). HER1-3 status and expression of membranous phosphorylated ER (sites serine 118 and 167) had previously been determined. All statistical calculations were performed using SPSS 15, including Kaplan-Meier life table analysis with log rank testing of differences in breast cancer related relapse whilst on tamoxifen.&amp;#x2028; Results&amp;#x2028; Membranous pSrc215 was observed in 20.3% of the cases but was more frequently observed in the cytoplasm (85.9%) and nucleus (90.5%). Overexpression of cytoplasmic pSrc215 was associated with an earlier time to recurrence (p = 0.037).&amp;#x2028; &amp;#x2028; Cox regression analysis confirmed this to be independent of grade, nodal and HER1-3 status (p=0.028, HR 3.17 (1.14–8.85)). Cytoplasmic pSrc215 was also strongly correlated with membranous phospho-ER, EGFR and HER3 status (Mann Whitney; p&amp;lt;0.001, p=0.026, p&amp;lt;0.001 respectively). Membranous and nuclear pSrc215 staining were not associated with time to relapse.&amp;#x2028; Over expression of Total Src and pSrc416 did not predict for relapse.&amp;#x2028; Discussion&amp;#x2028; Our findings provide support to in vitro studies linking c-Src with tamoxifen resistance. The phosphorylation site pSrc215 is a putative site of activation by HER2 and PGFR resulting in up to 50 fold activation of Src in vitro. The correlations demonstrated with HER status and membranous ER lead us to speculate that this interplay between non genomic ER and Src activation may provide a mechanism for the lack of response to tamoxifen in these patients.&amp;#x2028; Further studies are required to determine if activated pSrc215 represents activated c-Src alone or may also represent activation of other Src family members as the Y416 and Y215 sequences are highly conserved amongst the Src kinases with homologous activation sites. If confirmed, future use of novel combination therapies with Src inhibitors may have an important role in combating tamoxifen resistance. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 3025.
An Address on THE ACUTE ABDOMEN
Authors: E. R. Flint
Journal: BMJ (1928)

THE ACGUTE ABDOMIEN[ TK fL-JrUB 209 in Chlelsea, a licenitiate of the Apothecaries' Hall, and(l " one of tile livery."Mr. Knight presented it to the Hall in 1857.Now, in her researches into the hiistory of Reynold.s'sggeat picture, Miss Tildesley was puzzled by tllis curious ceircunmstance: Fromii Reynolds's niotebook she founid that Huntitergave his first sittings, foui-in nu-Lmber, earlyv in 1786; the sketch then donie was showni iin the Academyi exhibitioni of 1786 as " the l)oprtrait of a genitlemlan."On) its rettun from the exhibitioni Huniter gave Reynolds an-othier sitting-in September.Then sometliing happened -probal)ld-a dissatisfaction witlh the result, b)oth on the part
Predictive value of serum thymidine kinase level for Ig-V mutational status in B-CLL
Authors: C Magnac, R Porcher, F Davi, J Nataf, B Payelle-Brogard, R P Tang, P Oppezzo, V Lévy, G Dighiero, F Ajchenbaum-Cymbalista
Journal: Leukemia (2003)
CD98hc (SLC3A2) drives integrin-dependent renal cancer cell behavior
Authors: Marina Poettler, Matthias Unseld, Kira Braemswig, Andrea Haitel, Christoph C Zielinski, Gerald W Prager
Journal: Molecular Cancer (2013)

Overexpression of CD98hc (SLC3A2) occurs in a variety of cancers and is suspected to contribute to tumor growth. CD98, a heterodimeric transmembrane protein, physically associates with certain integrin β subunit cytoplasmic domains via its heavy chain, CD98hc. CD98hc regulates adhesion-induced intracellular signal transduction via integrins, thereby, affecting cell proliferation and clonal expansion. Disruption of CD98hc led to embryonic lethality in mice (E 3.5 and E 9.5) and CD98hc −/− embryonic stem cell transplantation failed to form teratomas, while CD98hc over-expression in somatic cells resulted in anchorage-independent growth. However, it is unclear whether interference with CD98hc expression tumor cell behavior. Renal cell cancer cell lines have been used to determine the effect of CD98hc expression on cancer cell behavior using cell adhesion, cell trans-migration and cell spreading assays. Flow cytometric analysis was performed to study the rate of apoptosis after detachment or serum starvation. shRNA-lentiviral constructs were used to stably knockdown or reconstitute full length or mutated CD98hc. The role of CD98 as a promotor of tumorigenesis was evaluated using an in in vivo tumor transplantation animal model. Immunohistochemical analysis was performed to analyze cell proliferation and CD98 expression in tumors. This report shows that CD98hc silencing in clear cell renal cancer cells reverts certain characteristics of tumorigenesis, including cell spreading, migration, proliferation and survival in vitro, and tumor growth in vivo. Acquisition of tumorigenic characteristics in clear cell renal cancer cells occurred through the integrin binding domain of CD98hc. A CD98hc/integrin interaction was required for adhesion-induced sustained FAK phosphorylation and activation of the major downstream signaling pathways PI3k/Akt and MEK/ERK, while overexpression of a constitutive active form of FAK rescued the CD98hc deficiency. In this study we demonstrate that loss of CD98hc blocks tumorigenic potential in renal cell cancer.
The Future General Internist
Authors: Robert N. Santella
Journal: Annals of Internal Medicine (1995)

Letters15 July 1995The Future General InternistRobert N. SantellaRobert N. SantellaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-2-199507150-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Although I agree with the definition of the general internist in the recently published position paper [1], I was disappointed that the Task Force on Physician Supply rejects the option of a “subspecialist” fulfilling the role of a general internist. What disqualifies a board-certified internist who happens to have completed subspecialty training from practicing high-quality general internal medicine? The Task Force proposes a double standard: They encourage general internists without formal subspecialty training to become local experts in an organ-based area in their practice locale but do not allow the subspecialist to practice general internal medicine. The ...REFERENCE1. American College of Physicians. The role of the future general internist defined. Ann Intern Med. 1994; 121:616-22. Google Scholar Author, Article, and Disclosure InformationAuthors: Robert N. SantellaAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 July 1995Volume 123, Issue 2Page: 156-158KeywordsForecastingPreventive medicineSub-specialty careTraditional medicine ePublished: 15 August 2000 Issue Published: 15 July 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Many detainees shouldn't be there in the first place
Authors: C. Goldwyn
Journal: BMJ (2013)

I welcome the transfer of healthcare from the UK Border Agency to the NHS in immigration removal centres.1 I am a retired GP and have been visiting such centres as a volunteer doctor for the past six years. I have been involved with more than 370 asylum seekers, 306 of them in immigration removal centres, and at least 180 of …
Essential Emergency Trauma
Authors: Suzanne Dooley-Hash
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Need for Biomedically and Contextually Sound Care Plans in Complex Patients
Authors: Saul J. Weiner, Alan Schwartz
Journal: Annals of Internal Medicine (2010)

Letters2 November 2010The Need for Biomedically and Contextually Sound Care Plans in Complex PatientsSaul J. Weiner, MD and Alan Schwartz, PhDSaul J. Weiner, MDFrom Jesse Brown Veterans Affairs Medical Center and University of Illinois at Chicago, Chicago, IL, 60612, and University of Illinois at Chicago, Chicago, IL 60680.Search for more papers by this author and Alan Schwartz, PhDFrom Jesse Brown Veterans Affairs Medical Center and University of Illinois at Chicago, Chicago, IL, 60612, and University of Illinois at Chicago, Chicago, IL 60680.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-9-201011020-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:A finding of our study that surprised us was that although physicians who spent more time with patients were more likely to probe for biomedical or contextual red flags, they were not more likely to provide contextually appropriate care. For example, in the case of a patient whose health literacy problems accounted for an inability to dose his diabetes medications correctly, physicians more often identified the literacy issue during longer visits but were not more likely to appropriately intervene. Physicians who intervened, however, did not on average have longer visits. Physicians who avoid contextual errors seem to think ...Reference1. Schwartz A, Weiner SJ, Harris IB, Binns-Calvey A. An educational intervention for contextualizing patient care and medical students' abilities to probe for contextual issues in simulated patients. JAMA. 2010;304:1191-7. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Jesse Brown Veterans Affairs Medical Center and University of Illinois at Chicago, Chicago, IL, 60612, and University of Illinois at Chicago, Chicago, IL 60680.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoContextual Errors and Failures in Individualizing Patient Care Saul J. Weiner , Alan Schwartz , Frances Weaver , Julie Goldberg , Rachel Yudkowsky , Gunjan Sharma , Amy Binns-Calvey , Ben Preyss , Marilyn M. Schapira , Stephen D. Persell , Elizabeth Jacobs , and Richard I. Abrams Metrics 2 November 2010Volume 153, Issue 9Page: 620KeywordsConflicts of interestLiteracyReasoning ePublished: 2 November 2010 Issue Published: 2 November 2010 CopyrightCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells.
Authors: H H Jabara, S M Fu, R S Geha, D Vercelli
Journal: The Journal of Experimental Medicine (1990)

A novel pathway of IgE-B cell differentiation has been identified. Engagement of the B cell antigen CD40 by F(ab')2 fragments of monoclonal antibody (mAb) 626.1 in the presence of recombinant interleukin 4 (rIL-4) induced intense IgE synthesis, but modest IgG synthesis, by highly purified human B cells. Surface IgE- B cells isolated by cell sorting were induced to produce IgE by mAb 626.1 and IL-4. Thus, IgE synthesis is unlikely to result from expansion of a B cell population precommitted to IgE in vivo. A neutralizing anti-IL-6 antibody strongly, but not completely, inhibited the IgE response. This indicates that autocrine production of IL-6 plays an important amplification role in IgE synthesis triggered by anti-CD40 mAb and IL-4. Although the exact role played by CD40 in IgE responses in vivo remains to be established, this T cell-independent system represents a useful model to characterize the biochemical and molecular events leading to IgE synthesis in human B cells.
Cross-sectional echocardiographic detection of aortic obstruction. 2. Coarctation of the Aorta.
Authors: A E Weyman, R L Caldwell, R A Hurwitz, D A Girod, J C Dillon, H Feigenbaum, D Green
Journal: Circulation (1978)

Cross-sectional echocardiographic studies of the aortic arch and proximal descending aorta were performed in 18 patients with coarctation of the aorta and 20 normal subjects. In normals the aortic arch and proximal descending aorta appeared as an arcuate, echo-free structure curving across the plane of the scan. There were no localized changes in aortic diameter and the amplitude of aortic systolic pulsation was symmetrically maintained throughout the scan plane. Visualization of this region was possible in 16 of 18 patients with coarctation. In each of these cases there was a localized area of decrease in aortic diameter in the region of the left subclavian artery which corresponded to the angiographic appearance of the coarctation. In addition prominent systolic pulsation of the aortic arch proximal to the region of obstruction was evident. Cross-sectional echocardiography may offer a useful noninvasive method for direct visualization of aortic coarctation.
Indian government allocates nearly half its disaster budget for drought relief in Maharashtra
Authors: P. Chatterjee
Journal: BMJ (2013)

Maharashtra state in western India is experiencing its worst drought in 40 years. At least a third of the state is affected, and thousands of villages face water shortages. 

Poor rainfall in western Maharashtra and the central Marathwada region of the state throughout the 2012 monsoon resulted in dry soil and a shortage of storage water for irrigation. Dams have become rapidly depleted of water in three districts, Nashik, Pune, and Aurangabad. 

The reservoir at Jayakwadi, the biggest dam in Maharashtra, has negligible water, an official statement noted last month. At least six districts have an acute shortage of drinking water, and the government …