tbuckley/cabot-search huggingface dataset:
Abstract LB-150: Local maturation and inhibition of antitumor CD8 T-cell responses in a model of immunoevasive breast cancer
Authors: Bijan A. Boldajipour, Matthew F. Krummel
Journal: Cancer Research (2014)

Abstract The purpose of this study is to investigate the cell interactions and mechanisms that limit anti-tumor CD8 T cell responses in tumor microenvironments. We used cutting-edge multiphoton imaging of immunoevasive tumors to determine the behavior and anti-tumor responses of CD8 T cells. This was achieved by adoptively transferring T cells into a modified MMTV-PyMT breast tumor model (mouse mammary tumor virus promoter-driven, polyoma middle T antigen-induced luminal breast cancer). In this model, tumor cells expresses ovalbumin as tumor-antigen and mCherry as a fluorescent markers, thus allowing immunologic assessment and intravital imaging of T cell activity against tumor cells in and ex vivo. Furthermore, we were able to investigate the effect of antigen-presenting immune cells and immunomodulatory treatment regimens on anti-tumor T cell activity in and ex vivo. In this work we found that newly arriving tumor-specific T cells undergo defined phases of maturation within the tumor microenvironment. First, after arriving to the tumor site, T cells engage in close interactions with antigen-presenting cells and exhibit reduced motility and rounded morphology. After this initial phase, T cells dramatically increase motility and survey the tumor microenvironment, however they do not form stable interactions with other cell types and further do not engage tumor cells. In contrary to other publications, swarming T cells do not express surface markers associated with exhaustion or anergy, and exhibit extensive in situ proliferation and ex vivo CTL activity. The capability of tumor CD8 T cells to kill targets ex vivo conflicts with the absence of tumor cell death in vivo. Additionally, individual immune cell populations isolated from tumors or tumor culture supernatants do not exhibit T cell suppressive capability when added as supplements to killing assays. Our results define sequential fates for T cells entering tumor microenvironments, suggesting that tumor-infiltrating lymphocytes exist in distinct ‘states’ depending on the extent to which tumor antigen-presenting cells have matured them. Further, T cell suppression appears to be a local phenomenon and cannot be achieved by soluble factors or a specific cell type alone. This may suggest that combinations of therapies that individually target the different maturation states are required to achieve therapeutic effects. Citation Format: Bijan A. Boldajipour, Matthew F. Krummel. Local maturation and inhibition of antitumor CD8 T-cell responses in a model of immunoevasive breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-150. doi:10.1158/1538-7445.AM2014-LB-150
STUDIES OF THE DISTRIBUTION OF POLIOMYELITIS VIRUS
Authors: Gordon C. Brown, Thomas Francis, John Ainslie
Journal: The Journal of Experimental Medicine (1948)

The occurrence and duration of the carrier state in familial associates of recognized cases of poliomyelitis was studied by the examination for virus of stool specimens collected from the members of four families at regular intervals for a period of over 2 months. The results indicate that: (1) virus may persist in their stools continuously for 4 to 5 weeks; (2) virus may be encountered intermittently in the stools; (3) in some instances virus may be present for brief periods only; (4) children are more likely to maintain virus than are adults in the same family; (5) infection of a family takes place rapidly, suggesting again simultaneous infection from a common source.
DYSMENORRHEA RELIEVED BY RESECTION OF PRESACRAL SYMPATHETIC NERVES
Authors: ALFRED W. ADSON
Journal: JAMA (1934)

Our satisfactory results in the treatment of peripheral vascular disease by sympathetic ganglionectomy and trunk resection have encouraged us to carry out investigations of diseases resulting from dysfunction of the sympathetic nervous system. The present report is a review of six cases of dysmenorrhea relieved by section of the presacral nerve, the operation described by Cotte in 1924. <h3>HISTORICAL DATA</h3> Jaboulay<sup>1</sup>is credited with making the first attempt to relieve pelvic pain by interrupting the afferent pathways in the sacral sympathetic chain. Ruggi<sup>2</sup>contributed to this investigation by performing abdominal sympathectomy for functional disturbances of the female genital organs, and he advised resection of the utero-ovarian plexus by the transperitoneal route. The results of Jaboulay's and Ruggi's operations were only partially successful; some patients were relieved, some were partially relieved, and others had recurrence of pain. Leriche<sup>3</sup>introduced periarterial sympathectomy of the internal iliac artery as a
Commentary: unusual manifestations of aspergillosis.
Authors: D W Denning
Journal: Thorax (1995)

A case of angiotropic large cell lymphoma is reported in which the patient presented with only pulmonary symptoms. It suggests that this rare and highly malignant lymphoma should be considered in the differential diagnosis of interstitial lung disease, and shows the value of open lung biopsy in unexplained interstitial lung disease. This patient responded well to treatment with cyclophosphamide, doxorubicin, vincristine, and prednisone.
Red-cell Aplasia and Benign Thymoma
Authors: E. H. O. Parry, G. S. Kilpatrick, R. M. Hardisty
Journal: BMJ (1959)

and Conclusions A brief review is given of the various materials used in treatment that have been responsible in the past for conveying tetanus.In the present investigation 666 samples of various forms of dressing materials were examined for tetanus bacilli by 14 public health laboratories situated in different parts of England.Tetanus bacilli were isolated from 23 samples.Of these, all but three were of unbleached cotton-wool or cotton-wool bandages, most of them coming from a single firm.These results suggest that contaminated dressings are a possible source of post-operative tetanus.Contaminated gloves may be of equal or greater danger, but no observations were made on them.It is concluded that every attempt should be made to prevent tetanus spores being carried into the theatre by air, street dust, dressings, or in other ways.All dressings should be sterilized before being taken into the theatre suite, and not in the theatre suite itself.We thank all members of the regional hospital boards and hospital management committees who provided the necessary samples for examination.
Technetium-99m Red Blood Cell Scintigraphy in Diagnosis of Hepatic Hemangioma
Authors: R PRAKASH, A JENA, V BEHARI, M K CHOPRA
Journal: Clinical Nuclear Medicine (1987)

Tc-99m RBC scintigraphy was performed in an intrahepatic mass lesion detected on a sulfur colloid scan. The flow study showed the lesion to be avascular except for four discrete areas of increased vascularity in the right lobe. The serial blood pool scintigrams up to 2 hours after injection showed progressive filling of the mass lesion, indicative of increased blood volume. The scintigraphic diagnosis of hepatic hemangioma, based on discordant flow and blood pool images, was confirmed by computed tomography and contrast angiography.
US research scientist found guilty of fraud
Authors: R. Dobson
Journal: BMJ (1999)

A scientist who produced key research papers on the possible biological effects of low intensity electromagnetic fields has been found to have intentionally falsified and fabricated data.

The US Office of Research Integrity's verdict on Dr Robert Liburdy comes in the wake of similar conclusions by a committee at the Lawrence Berkeley National Laboratory, where he worked.

The office says that Dr Liburdy, a biochemist who received around $6m (£3.75m) in federal research grants over the past decade, neither admits nor denies its …
Specificity of affiliation supported by neurotransmitter challenge tests and molecular genetics
Authors: Petra Netter, Martin Reuter, Juergen Hennig
Journal: Behavioral and Brain Sciences (2005)

Support for a neurobiological distinction between affiliation (Attachment) and agency (Achievement) was achieved by comparing responses to a dopaminergic (DA) and a serotonergic (5-HT) challenge test. DA responses were similar, but a 5-HT modulation of DA emerged for Achievement and not for Attachment. Molecular genetics performed on Panksepp’s dimension “Care” revealed an association with a polymorphism of the DA catabolizing enzyme COMT that was not associated with separation distress.
How Well Do Patients’ Assessments of Their Diabetes Self-Management Correlate With Actual Glycemic Control and Receipt of Recommended Diabetes Services?
Authors: Michele Heisler, Dylan M. Smith, Rodney A. Hayward, Sarah L. Krein, Eve A. Kerr
Journal: Diabetes Care (2003)

Although patient diabetes self-management is a key determinant of health outcomes, there is little evidence on whether patients' own assessments of their self-management correlates with glycemic control and key aspects of high-quality diabetes care. We explored these associations in a nationwide sample of Veterans' Affairs (VA) patients with diabetes.We abstracted information on achieved level of glycemic control (HbA(1c)) and diabetes processes of care (receipt of HbA(1c) test, eye examination, and nephropathy screen) from medical records of 1032 diabetic patients who received care from 21 VA facilities and had answered the Diabetes Quality Improvement Program survey in 2000. The survey included sociodemographic measures and a five-item scale assessing the patients' diabetes self-management (medication use, blood glucose monitoring, diet, exercise, and foot care [alpha = 0.68]). Using multivariable regression, we examined the associations of patients' reported self-management with HbA(1c) level and receipt of each diabetes process of care. We adjusted for diabetes severity and comorbidities, insulin use, age, ethnicity, income, education, use of VA services, and clustering at the facility level.Higher patient evaluations of their diabetes self-management were significantly associated with lower HbA(1c) levels (P < 0.01) and receipt of diabetes services. Those in the 95th percentile for self-management had a mean HbA(1c) level of 7.3 (95% CI 6.4-8.3), whereas those in the 5th percentile had mean levels of 8.3 (7.4-9.2). For every 10-point increase in patients' ratings of their diabetes self-management, even after adjusting for number of outpatient visits, the odds of receiving an HbA(1c) test in the past year increased by 15% (4-27%), of receiving an eye examination increased by 16% (7-27%), and of receiving a nephropathy screen increased by 13% (2-26%).In this sample, patients' assessments of their diabetes self-care using a simple five-question instrument were significantly associated both with actual HbA(1c) control and with receiving recommended diabetes services. These findings reinforce the usefulness of patient evaluations of their own self-management for understanding and improving glycemic control. The mechanisms by which those patients who are more actively engaged in their diabetes self-care are also more likely to receive necessary services warrant further study.
No difference between supine and prone position for ERCP in conscious sedated patients: a prospective randomized study
Authors: A. Tringali, M. Mutignani, A. Milano, V. Perri, G. Costamagna
Journal: Endoscopy (2007)

See also: Commentaire de travail de A. Tringali et al., pp. 93Endoscopy 2008; 40(02): 234-235DOI: 10.1055/s-0032-1306810
Caffeine and exhaled nitric oxide
Authors: T J Warke
Journal: Thorax (2003)

Revision of BTS guidelines for treatment of asthmaThe paper by Ward et al 1 confirms the findings of Laitinen et al 2 showing that airways inflammation is present even in patients with mild asthma.This emphasises the importance of using anti-inflammatory drugs (steroids) as soon as the diagnosis of asthma has been confirmed, even in patients thought to have only "mild asthma".Without antiinflammatory treatment, symptoms resulting from bronchial hyperresponsiveness are never controlled and optimal lung function is never attained.Over time, structural changes (remodelling) occur leading to a progressive decline in lung function 3 and the risk of fixed obstruction (chronic obstructive pulmonary disease).The present widespread dependence on bronchodilators in the UK may contribute to the fact that we have one of the highest respiratory death rates in Europe. 4The use of bronchodilators alone as in step 1 of the BTS guidelines should be discouraged, and treatment started at step 2 with regular inhaled corticosteroids to control symptoms and maximise peak flow rate.Bronchodilators should be used only as necessary for breakthrough wheezing.These principles have been used in Finland since 1994 with remarkable success in treating asthma. 5 The new BTS guidelines would do well to follow their example.
Inverse Relation between Serum IgG Concentration and Glucose and Xylose Absorption in Zambian African Adults
Authors: G. C. Cook
Journal: BMJ (1974)

In three separate investigations in Zambian African adults in Lusaka an inverse association has been shown between serum IgG concentration and either glucose absorption rate from the jejunum (from a 200-mM solution) or xylose absorption (from a 25-g oral load). In developing areas of the world, where serum IgG concentrations are often high, this finding may have widespread nutritional implications.
Hypothalamic-pituitary-adrenal activity in type 2 diabetes mellitus: role of autonomic imbalance
Authors: Iacopo Chiodini, Sergio Di Lembo, Valentina Morelli, Paolo Epaminonda, Francesca Coletti, Benedetta Masserini, Alfredo Scillitani, Maura Arosio, Guido Adda
Journal: Metabolism (2006)
MASTOIDITIS AND LATERAL SINUS THROMBOSIS IN AN INFANT
Authors: LOUIS H. SEGAR
Journal: JAMA (1931)

That mastoiditis may occur at an early age without evidence of middle ear involvement has been recognized by numerous observers.1Of thirty-five cases of mastoiditis in children, Steinsleger2encountered nine in the range of ages from 7 weeks to 23 months Seven of these nine cases, or 77 per cent, showed no perforation of the tympanic membrane previous to operation. Grulee3states that sinus thrombosis in the new-born is due either to a general infection in the blood stream or to direct extension from the ear, and that it is practically impossible to differentiate it from meningitis when symptoms are present.  The following case is an example of the tender age at which these conditions may be found and of the insidious manner in which they may develop.  REPORT OF CASE  The parents had one other child, aged 6 years, in excellent health. There was no history
Judge awards record sums in breast implant deal
Authors: C Dyer
Journal: BMJ (1994)

A judge in Birmingham, Alabama, has approved a $4.25bn (sterling2.83bn) compensation deal for more than 90 500 women worldwide with silicone breast implants. It is the biggest product liability settlement in legal history in the US. The deal was struck after thousands of women sued manufacturers, including Dow Corning, Bristol-Myers, and Union Carbide, for damages for alleged complications, including serious neurological and immune disorders.

Final approval by Judge Sam Pointer came just days after a hearing at which lawyers for foreign claimants argued that the settlement, which proposed to cap payment to foreigners, was unfair to their clients. The judge increased …
Reply from Author re: Maurizio Brausi, Salvatore Siracusano. Collateral Activity of Immunotherapy with Bacillus Calmette-Guérin for the Treatment of Non–muscle-invasive Transitional Cell Carcinoma of the Bladder: New Insights. Eur Urol 2013;63:836–7
Authors: Harry W. Herr
Journal: European Urology (2012)
The Emerging Role of “Hospitalists” in the American Health Care System
Authors: R M Wachter, L Goldman
Journal: New England Journal of Medicine (1996)

The explosive growth of managed care has led to an increased role for general internists and other primary care physicians in the American health care system. This change is welcome in many respects, since generalists have perennially been undervalued by health care institutions, payers, and even patients.13 The greater prominence of generalism has led to an increase in the number of medical students who choose careers in primary care,4 expanded job opportunities for generalists,5 and a modest increase in the incomes of primary care physicians.6 Two of the principles underlying generalism, whether in the form of internal medicine, pediatrics, . . .
Juvenile plantar dermatosis
Authors: J.L. Verbov
Journal: British Journal of Dermatology (1979)

Journal Article Juvenile plantar dermatosis Get access J.L. Verbov J.L. Verbov Sefton General Hospital, Liverpool Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 101, Issue 6, 1 December 1979, Page 733, https://doi.org/10.1111/j.1365-2133.1979.tb05658.x Published: 01 December 1979
Depression of cellular immunity as an index of malnutrition in surgical patients
Authors: J A R Smith
Journal: BMJ (1981)

Definitions of mild cognitive impairment (MCI) vary, yielding conflicting results. For example, case definitions affect prevalence but not outcomes in prevalent cases. Our objective was to determine whether variation in case definitions affects outcomes in incident cases of MCI. The 5 year risks of death, institutionalisation, and dementia were evaluated in clinically examined incident MCI cases in the Canadian Study of Health and Aging. The definition of MCI was varied so as to include or relax combinations of diagnostic features from consensus criteria. Relative risks (RR) of each adverse outcome were highest in MCI case definitions that required subjective memory complaints (for example, RR of dementia = 26.4–38.7). Although each MCI definition conferred an increased risk of dementia, for each case definition 20–30% of survivors had no cognitive impairment at follow up. In this population based study, MCI represented a transitional state, but was heterogeneous, with substantial proportions recovering, regardless of how MCI was defined. Factors associated with recovery and non-progression in MCI require elucidation.
Vasoactive intestinal polypeptide mediates cholecystokinin-induced relaxation of the sphincter of Oddi.
Authors: J W Wiley, T M O'Dorisio, C Owyang
Journal: Journal of Clinical Investigation (1988)

This study evaluates the hypothesis that cholecystokinin (CCK) relaxes the sphincter of Oddi via vasoactive intestinal polypeptide (VIP). Isolated canine sphincter of Oddi were suspended in organ baths under standard conditions. Responses to cholecystokinin octapeptide (CCK-8) and VIP were recorded on a pen recorder via an isometric transducer. 10(-11)-10(-7) M CCK-8 and 4 X 10(-11)-5 X 10(-7) M VIP generated dose-related sphincter of Oddi relaxation, which was unaffected by atropine, propranolol, and phentolamine. The effect of CCK-8 was antagonized by dibutyryl cGMP (Bt2 cGMP) (10(-3) M), the VIP-antagonist (N-Ac-Tyr1, D-Phe2)-growth hormone-releasing factor-(1-29)-NH2, and abolished by tetrodotoxin. In contrast, VIP's relaxing action was tetrodotoxin insensitive. 10(-11)-10(-7) M CCK-8 stimulated dose-dependent release of VIP (0.5-2.2 fm/ml.mg tissue), which was not inhibited by atropine, propranolol, and phentolamine, but was antagonized by 10(-3) M Bt2 cGMP and tetrodotoxin. In addition CCK-8 and VIP generated dose-related (10(-10)-10(-7) M) increases in sphincter of Oddi cAMP levels that were not affected by atropine, propranolol, and phentolamine. Furthermore, 10(-5)-10(-2) M 8-bromo-cAMP caused dose-dependent relaxation of the sphincter of Oddi. In separate studies, a 2-h incubation in physiological solution containing 12 parts/1,000 of rabbit VIP antiserum antagonized sphincter relaxation caused by 4 nM CCK-8 and 6 nM VIP. The antiserum also significantly decreased the sphincter of Oddi cAMP level stimulated by 4 nM CCK-8 by 48 +/- 15%. These studies demonstrate that CCK-8 relaxes the canine sphincter of Oddi via a noncholinergic, nonadrenergic neural pathway involving VIP. The intracellular mechanism mediating CCK/VIP relaxation involves generation of cAMP.
Cytokeratins 16 and 10 bind to retinoic acid covalently in skin tissue of mice
Authors: N. Takahashi, Y. Fujiu
Journal: British Journal of Dermatology (2009)

Retinoic acid (RA) has various biological effects in mammalian cells and tissues. In epidermal cells, RA is an inhibitor of differentiation to the squamous phenotype. The molecular mechanisms underlying the effects of RA on epidermal cells and other cell types are mediated by RA nuclear receptors and retinoylation (acylation by RA) of proteins.To understand the components responsible for RA effects via RA nuclear receptors and retinoylation.We examined for the first time RA-binding proteins in mouse skin in vivo by immunoblotting using anti-RA monoclonal antibodies and identified by matrix-assisted laser desorption ionization-time of flight mass spectrometry.We identified eight RA-binding proteins in the skin of hairless mice that were increased by topical RA treatment. Three of these proteins were identified as cytokeratin 10, cytokeratin 16 and serum albumin.These results raise the possibility that RA binding to cytokeratins in vivo may be involved in the effect of RA on keratinocytes in mouse skin.
INCREASED SUPERFICIAL BRIGHT SPOTS AT THE CULPRIT LESION IN PATIENTS WITH ACUTE CORONARY SYNDROME: AN OPTICAL COHERENCE TOMOGRAPHY STUDY
Authors: Yoshiyasu Minami, Jennifer Phipps, Taylor Hoyt, Daniel S Ong, Rocco Vergallo, Marc D Feldman, Ik-Kyung Jang
Journal: Journal of the American College of Cardiology (2015)