Alpha-Interferon and Reversible Hypertriglyceridemia
Authors: Donna Graessle
Journal: Annals of Internal Medicine (1993)

Letters15 February 1993Alpha-Interferon and Reversible HypertriglyceridemiaDonna Graessle, MD, Maurizio Bonacini, MD, and Stuart Chen, MDDonna Graessle, MD, Maurizio Bonacini, MD, and Stuart Chen, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-4-199302150-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We report a case of reversible hypertriglyceridemia in a patient receiving α-interferon for chronic hepatitis C infection. A 36-year-old man with diabetes mellitus who was receiving oral glyburide, 10 mg daily, was started on 3 million units of subcutaneous α-interferon, thrice weekly. The patient was hepatitis C seropositive, and a liver biopsy showed chronic, active hepatitis. His baseline serum triglyceride level was 3.8 mmol/L (340 mg/dL), and his serum cholesterol level was 5.7 mmol/L (220 mg/dL). After the first week of interferon therapy, the patient's serum lipids rose to a peak of 22.4 mmol/L (1980 mg/dL) and ...References1. Feingold KR, Soued M, Kerala Serio M, et al. Multiple cytokines stimulate hepatic lipid synthesis in vivo. Endocrinology. 1989; 125: 267-74. Google Scholar2. Olsen EA, Lichtenstein GR, Wilkinson WE. Changes in serum lipids in patients with Condylomata acuminata treated with interferon alfa-n1. J Am Acad Dermatol. 1988; 19:286-9. Google Scholar3. Grunfeld C, Kotler DP, Shigenaga JK, et al. Circulating interferon-α levels and hypertriglyceridemia in the acquired immunodeficiency syndrome. Am J Med. 1991; 90:154-62. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHypertriglyceridemia in patients with metastatic breast cancer and treatment with capecitabineSerum lipids in European chronic HCV genotype 1 patients during and after treatment with pegylated interferon-α-2a and ribavirinEvaluation and Treatment of the HIV/HCV Coinfected Patient: A Case History and DiscussionTolerability of Treatments for Viral HepatitisEffects of interferon-beta on plasma lipid and lipoprotein composition and post-heparin lipase activities in patients with chronic hepatitis CInterferón y lípidos plasmáticosAcute Pancreatitis Associated with Interferon Alpha Therapy for Chronic Myelogenous LeukemiaHypertriglyceridaemia following adjuvant interferon-α treatment in two patients with malignant melanomaLipoprotein changes in patients with chronic hepatitis C treated with interferon-αInterferon-α for Viral HepatitisHepatitis C virus infection: clinical aspects and treatment with interferon alfaSerum Lipid Levels During Interferon Therapy in Patients with Chronic Hepatitis CHypertriglyceridemia may be severe in CML patients treated with interferon-αA retrospective study of hepatitis C virus carriers in a local endemic town in JapanInterferons for viral hepatitisInterferon alpha 15 February 1993Volume 118, Issue 4Page: 316-317KeywordsChronic hepatitis CHIVHepatitis AHepatitis CInterferonsLipid metabolismLipid profilesLipidsLiverSerum triglycerides Issue Published: 15 February 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...