tbuckley/cabot-search huggingface dataset:
Interactions between Sympathomimetic Amines and Antidepressant Agents in Man
Authors: A. J. Boakes, D. R. Laurence, P. C. Teoh, F. S. K. Barar, L. T. Benedikter, B. N. C. Prichard
Journal: BMJ (1973)

Intravenous infusions of phenylephrine, noradrenaline, adrenaline, and isoprenaline were given to healthy human volunteers after five to seven days on phenelzine, tranylcypromine, or imipramine, and cardiovascular responses were compared with those observed under control conditions. With monoamine oxidase inhibitors there was a 2-2½ fold potentiation of the pressor effect of phenylephrine, but no clinically significant potentiation of cardiovascular effects of noradrenaline, adrenaline, or isoprenaline. With imipramine there was potentiation of the pressor effects of phenylephrine (2-3 fold), noradrenaline (4-8 fold), and adrenaline (2-4 fold); there were dysrhythmias during adrenaline infusions, but no noticeable or consistent changes in response to isoprenaline. Noradrenaline and adrenaline in amounts contained in local anaesthetics used in dentistry are not likely to be significantly potentiated in otherwise healthy patients receiving monoamine oxidase inhibitors. Hazardous potentiation of their cardiovascular effects might occur in patients receiving tricyclic antidepressants. Our observations do not indicate that the hazards associated with isoprenaline inhalation by bronchial asthmatics would be increased by coincident therapy with a monoamine oxidase inhibitor or tricyclic antidepressant.
Autonomic Neuropathy Complicating Rheumatoid Arthritis
Authors: Samuel Vaisrub
Journal: JAMA (1980)

Whether associated with peripheral neuropathy, as is usually the case, or not, autonomic neuropathy, particularly that of the cardiovascular system, does not burden the mind with a cumbersome differential diagnosis. In fact, the diagnostic exercise halts after an instant evocation of diabetes. So much has been written recently about diabetic autonomic neuropathy and its effects on the heart and circulation that one tends to overlook other etiologic links. One such link is with rheumatoid arthritis. Its existence, suspected by Kalliomäki et al<sup>1</sup>(1963) and Bennett and Scott<sup>2</sup>(1965) on the basis of deficient sweating responses in patients with rheumatoid arthritis and peripheral neuropathy, has been recently confirmed by Edmonds et al.<sup>3</sup>These investigators demonstrated autonomic neuropathy by assessing the integrity of cardiovascular reflexes in 68 subjects who were divided into four groups: patients with classic rheumatoid arthritis both seropositive and seronegative, patients with osteoarthritis, an older control
Age and Mental Incompetence
Authors: MARSHALL B. KAPP
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 May 1983Age and Mental IncompetenceMARSHALL B. KAPP, J.D., M.P.H.MARSHALL B. KAPP, J.D., M.P.H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-5-669_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article by Thomasma (1) will no doubt inspire serious and heated debate among physicians, ethicists, and attorneys concerned with the physician-patient relationship. I wish to comment on one sentence in the paper that, although minor in terms of the whole article, represents a widespread and serious misconception that cries out for correction.In his defense of weak paternalism, Thomasma asserts that "an action may need no justification if the patient is not competent to give consent due to age or mental status." The implication, which is generally accepted, is that old age alone is sufficient legal...References1. THOMASMA D. Beyond medical paternalism and patient autonomy: a model of physician conscience for the physician-patient relationship. Ann Intern Med. 1983;98:243-8. LinkGoogle Scholar2. KAPP M. Legal guardianship. Geriatric Nursing. 1981;2:366-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARSHALL B. KAPP, J.D., M.P.H. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRevival, Resuscitation, and Resurrection: The Rights of Passage 1 May 1983Volume 98, Issue 5_Part_1Page: 669-670 ePublished: 1 December 2008 Issue Published: 1 May 1983 PDF downloadLoading ...
MEASUREMENTS OF TL-201 UPTAKE AND OXIDATIVE METABOLISM IN CULTURED MYOCARDIAL CELLS
Authors: J. C. Maublant, N. Moins, P. Gachon, M. R. Ross, W. D. Davidson, I. Mena
Journal: Clinical Nuclear Medicine (1984)

Cultures of myocardial cells were utilized under controlled conditions in order to measure simultaneously their Tl-201 uptake and oxidative metabolism. The cultures were prepared by trypsinization of the myocardium of two to four-day old newborn mice. The cells were placed into flasks and two days later were incubated with C14-glucose or C14-octanoate. The flasks were inserted in an apparatus in which recirculating air was passing through a vibrating reed electrometer for detection of the beta radiations of the C14-CO2 liberated by the radioactive substrates. The rate of oxidation was measured from the recording of this activity. Various drugs affecting the cardiac metabolism were injected in 22 flasks, i.e., potassium cyanide (KCN), an inhibitor of mitochondrial respiration (MR), 2–4 dinitrophenol (DNP), an uncoupler of MR, and grisorixin, a potassium ionophore. The flasks were finally incubated for five minutes with 100μCi of Tl-201. After washing, the remaining activity was counted and the amount of protein measured. The ratio of intra/extracellular Tl-201 activity (Tl i/o) was 35±9 in 12 controls. The changes in oxidation (Δ%) and the Tl i/o in the treated flasks were (m±sd;*p<0.05): Octanoate Glucose Δ% Tl i/o Δ% Tl i/o KCN −45±22* 27±11 −28±15* 31±4 DNP 10±52 35±10 37±23 41±10 Grisorixin −50±16* 20±5* −11±12 17±3* These results demonstrate that in tissue cultures the Tl-201 uptake was partially dependent on the oxidative metabolism.
Role of ANO4 in regulation of aldosterone secretion in the zona glomerulosa of the human adrenal gland
Authors: Carmela Maniero, Junhua Zhou, Lalarukh H Shaikh, Elena A B Azizan, Ian McFarlane, Sudeshna Neogi, Paolo Scudieri, Louis J Galietta, Morris J Brown
Journal: The Lancet (2015)
An Address on CHRONIC INFECTION OF THE CERVIX: A FREQUENT CAUSE OF PELVIC AND GENERAL ILLNESS
Authors: J. Young
Journal: BMJ (1930)

BRJITISH 577 2. A 6-para, aged 37, for six years has had leuicorr-hoea with pain in the lower abdomen, exaggerated befo're and during menstruation.There hiave been bladder irritability -and frequency, headaches, ON ~~~~~~~~rlheumatic attacks in wrists, and constant feeling of fatigue.CHRONIC INFECTIONOF TIlE (ERVIX: pTiense inistancees are selected froim a large niumiber of patiilt in i-loiiicli i-c was prsn,anid iii A &FREQUE-NT CAUSE OF PELVIC A4ND whiomi tr-eatMent dir-ected to this conidition resulted eitlier GENER.
TRAUMATIC SEPARATION OF THE SYMPHYSIS PUBIS
Authors: Thomas D. Sparrow
Journal: JAMA (1930)

The literature is fairly prolific in reports of cases of separation of the symphysis pubis the result of parturition or some operative procedure incident to childbirth. There are records available of exceptionally few cases in which the separation of the symphysis has occurred from other types of trauma. Of these the majority have been due to falls. G. Schaanning<sup>1</sup>reports a case in a pregnant woman, almost at term, who slipped and fell on the street. Willan<sup>2</sup>reports two cases and Buckley<sup>3</sup>one case resulting from falls from horses. Koven's<sup>4</sup>case was due to an automobile accident. I have been unable to find a case similar to the one reported in this article, in which a weight applied to the anterior superior spines of the ilium resulted in a sacro-iliac dislocation and the folding out of the pelvic ring. J. B. A., a man, aged 66,
Topical cidofovir for erythroplasia of Queyrat of the glans penis
Authors: D. Calista
Journal: British Journal of Dermatology (2002)

Journal Article Topical cidofovir for erythroplasia of Queyrat of the glans penis Get access D. Calista D. Calista Department of Dermatology, 'M.Bufalini' Hospital, Viale Ghirotti 286, 47023 Cesena, Italy E‐mail: calista@iol.it Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 147, Issue 2, 1 August 2002, Page 399, https://doi.org/10.1046/j.1365-2133.2002.483111.x Published: 01 August 2002
Endothelin <sub>A</sub> Receptor Blockade Improves Nitric Oxide–Mediated Vasodilation in Monocrotaline-Induced Pulmonary Hypertension
Authors: Stéphane Prié, Duncan J. Stewart, Jocelyn Dupuis
Journal: Circulation (1998)

Background —Nitric oxide (NO) and endothelin (ET) have been implicated in the pathogenesis of pulmonary hypertension (PH). Chronic ET A antagonist therapy reduces PH in monocrotaline (MCT)-treated rats. Interactions between the l -arginine–NO pathway and the ET system have been described. We therefore studied the effect of long-term treatment with an oral ET A antagonist (LU 135252) on NO-related vasodilation in isolated lungs from control rats and rats with MCT-induced PH. Methods and Results —Three weeks after MCT injection, PH was associated with an increase in right ventricular pressure (from 27.4±0.9 to 66.6±4.1 mm Hg) and a decrease in endothelium-independent vasodilation in response to sodium nitroprusside (10 −10 to 10 −5 mol/ l ΔE max , from 11.1±0.9 to 2.7±0.3 mm Hg). Endothelium-dependent vasodilation in response to acetylcholine (10 −9 to 10 −4 mol/ l ) and the calcium ionophore A23187 (10 −9 to 10 −7 mol/ l ) remained unaffected. Treatment with LU 135252 did not significantly affect the endothelium-dependent and -independent vasodilations in control rats. However, in MCT-treated rats, LU 135252 therapy significantly reduced right ventricular pressure (39.7±2.1 mm Hg), potentiated acetylcholine-induced vasodilatation (ΔE max , from 1.6±0.2 to 3.7±0.4 mm Hg), and improved the responses to sodium nitroprusside (ΔE max , from 2.7±0.3 to 5.6±0.6 mm Hg). LU 135252 did not significantly alter the non–receptor-mediated endothelium-dependent vasodilation to A23187 or pulmonary constitutive NO synthase activity. Conclusions —MCT PH is associated with a reduced smooth muscle responsiveness to NO but a maintained endothelium-dependent vasodilatory potency. Long-term ET A antagonist therapy not only restores smooth muscle responsiveness to NO but also increases endothelium-dependent dilation in response to acetylcholine. This mechanism may contribute to the therapeutic benefit of ET A antagonists in PH.
Cost of treating pseudomembranous colitis
Authors: I Hamilton, I F Pinder
Journal: BMJ (1981)

globulin have a strong but not exclusive influence.' Changes in albumin have only a minor effect, but paraproteins2 and lipoproteins3 also increase plasma and serum viscosity.For these reasons estimations of plasma fibrinogen from the difference of plasma and serum viscosity are unreliable and can be wrong by as much as 100",.
Irratancy of anthralin in patients with psoriasis and widespread vitiligo
Authors: D.L.L. Robert
Journal: British Journal of Dermatology (1984)

Journal Article Irratancy of anthralin in patients with psoriasis and widespread vitiligo Get access D.L.L. Robert D.L.L. Robert singleton Hospital, Sketty, Swansea SA2 8QA Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 110, Issue 2, 1 February 1984, Page 247, https://doi.org/10.1111/j.1365-2133.1984.tb07477.x Published: 01 February 1984
Dickkopf-1 (DKK1) is a widely expressed and potent tumor-associated antigen in multiple myeloma
Authors: Jianfei Qian, Jin Xie, Sungyoul Hong, Jing Yang, Liang Zhang, Xiaohong Han, Michael Wang, Fenghuang Zhan, John D. Shaughnessy, Joshua Epstein, Larry W. Kwak, Qing Yi
Journal: Blood (2007)
Acute lymphoblastic leukemia – hand mirror variant – viral immune interrelationship as demonstrated by ultrastructural studies
Authors: Harold R. Schumacher, William J. Thomas, Michael Strong, William J. Creegan, Geoffrey Rowden, Terry M. Phillips, Newton S. More, Elliott Perlin, Sanford A. Stass
Journal: American Journal of Hematology (1981)

Abstract Acute lymphoblastic leukemia – hand mirror variant – was extensively restudied in a 22‐year‐old white female who survived for 22 months without therapy. Immune complexes to the baboon endogenous virus (BaEV) were found in the bone marrow plasma of the relapse specimen in 1977, but not in the bone marrow plasma from the terminal state in 1979. Immunoperoxidasetagged IgM antibody prepared from the patient's bone marrow plasma revealed BaEV antigen on the tip of the uropod of the HMC at the time immune complexes were found in the marrow. Absence of immune complexes in the bone marrow in the terminal state suggested a failure of the patient's immune surveillance system and/or possible immune suppression by chemotherapy.
Meta-analysis of short term low dose prednisolone versus placebo and non-steroidal anti-inflammatory drugs in rheumatoid arthritis
Authors: P. C Gotzsche, H. K. Johansen
Journal: BMJ (1998)

<h3>Abstract</h3> <b>Objective:</b> To determine whether short term, oral low dose prednisolone (⩽15 mg daily) is superior to placebo and non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis. <b>Design:</b> Meta-analysis of randomised trials of oral corticosteroids compared with placebo or a non-steroidal anti-inflammatory drug. <b>Setting:</b> Trials conducted anywhere in the world. <b>Subjects:</b> Patients with rheumatoid arthritis. <b>Main outcome measures:</b> Joint tenderness, pain, and grip strength. Outcomes measured on different scales were combined by using the standardised effect size (difference in effect divided by SD of the measurements). <b>Results:</b> Ten studies were included in the meta-analysis. Prednisolone had a marked effect over placebo on joint tenderness (standardised effect size 1.31; 95% confidence interval 0.78 to 1.83), pain (1.75; 0.87 to 2.64), and grip strength (0.41; 0.13 to 0.69). Measured in the original units the differences were 12 (6 to 18) tender joints and 22 mm Hg (5 mm Hg to 40 mm Hg) for grip strength. Prednisolone also had a greater effect than non-steroidal anti-inflammatory drugs on joint tenderness (0.63; 0.11 to 1.16) and pain (1.25; 0.26 to 2.24), whereas the difference in grip strength was not significant (0.31; −0.02 to 0.64). Measured in the original units the differences were 9 (5 to 12) tender joints and 12 mm Hg (−6 mm Hg to 31 mm Hg). The risk of adverse effects during moderate and long term use seemed acceptable. <b>Conclusion:</b> Prednisolone in low doses (⩽15 mg daily) may be used intermittently in patients with rheumatoid arthritis, particularly if the disease cannot be controlled by other means. <h3>Key messages</h3> Prednisolone in low doses—that is, no more than 15 mg daily—is highly effective in patients with rheumatoid arthritis The risk of adverse effects is acceptable in short, moderate, or long term use Oral low dose prednisolone may be used intermittently in patients with rheumatoid arthritis, particularly if the disease cannot be controlled by other means Further short term placebo controlled trials to study the clinical effect of prednisolone or other oral corticosteroids are no longer necessary
Legal issues in allergy and clinical immunology
Authors: Allan Gibofsky
Journal: Journal of Allergy and Clinical Immunology (1996)

Clinical risk management for the allergist focuses primarily on concerns regarding adverse occurrences and the possibility of civil litigation as a result of negligence or professional liability. Risk is substantially reduced with an understanding of such predictable drug reactions as overdosage, side effects, secondary effects, and drug interactions. In addition, all clinicians who prescribe have a duty to disclose to their patients the possibility of unpredictable reactions, including intolerance, idiosyncrasy, and allergy or hypersensitivity. This disclosure should be part of a comprehensive discussion of the risks and benefits of, and alternatives to, therapeutic agents and procedures they recommend. The process of informed consent becomes even more critical with the increasing influence of hospital and managed care formularies on prescribing decisions. Although cost effectiveness is an important factor in prescribing decisions, the possibility of adverse effects, treatment failure, noncompliance, and other negative considerations must also be weighed.
Long-Term Clinical Outcomes After Unprotected Left Main Trunk Percutaneous Revascularization in 279 Patients
Authors: Walter A. Tan, Hideo Tamai, Seung-Jung Park, H.W. Thijs Plokker, Masakiyo Nobuyoshi, Takahiko Suzuki, Antonio Colombo, Carlos Macaya, David R. Holmes, David J. Cohen, Patrick L. Whitlow, Stephen G. Ellis
Journal: Circulation (2001)

Background Percutaneous coronary revascularization (PCI) has been increasingly applied to unprotected left main trunk (LMT) lesions, with varied long-term success. This study attempts to define the predictors of outcome in this population. Methods and Results Two hundred seventy-nine consecutive patients who had LMT PCI at 1 of 25 sites between 1993 and 1998 were studied. Forty-six percent of these patients were deemed inoperable or at high surgical risk. Thirty-eight patients (13.7%) died in hospital, and the rest were followed up for a mean of 19 months. The 1-year incidence was 24.2% for all-cause mortality, 20.2% for cardiac mortality, 9.8% for myocardial infarction, and 9.4% for CABG. Independent correlates of all-cause mortality were left ventricular ejection fraction ≤30%, mitral regurgitation grade 3 or 4, presentation with myocardial infarction and shock, creatinine ≥2.0 mg/dL, and severe lesion calcification. For the 32% of patients &lt;65 years old with left ventricular ejection fraction &gt;30% and without shock, the prevalence of these adverse risk factors was low. No periprocedural deaths were observed in this low-risk subset, and the 1-year mortality was only 3.4%. Conclusions Patients undergoing unprotected LMT PCI have frequent serious comorbidities and consequently have high event rates. PCI may be an alternative to CABG for a select proportion of elective patients and may also be appropriate for highly symptomatic inoperable patients. Meticulous follow-up of hospital survivors is required because of the rather high mortality during the first few months after treatment.
The cytoskeleton of uterine epithelial cells: a new player in uterine receptivity and the plasma membrane transformation
Authors: C. Murphy
Journal: Human Reproduction Update (1995)

During early pregnancy and the period of blastocyst attachment, the plasma membrane of uterine epithelial cells, which is the first site of contact between maternal and fetal cells, undergoes a remarkable change in configuration, with morphological and biochemical alterations occurring apically and basolaterally. These alterations are collectively referred to as 'the plasma membrane transformation' of early pregnancy. It would be remarkable if this transformation did not also involve alterations in cytoskeletal elements and, in particular, the membrane-associated cytoskeleton. This review therefore, after an overview of the morphological and molecular aspects of the membrane transformation as background, proceeds to examine what is known about the cytoskeleton of uterine epithelial cells. Cytoskeletal elements particularly associated with the plasma membrane are then examined and some new approaches to understanding membrane-skeletal dynamics, including detergent-permeabilization techniques for transmission and high-resolution scanning electron microscopy of uterine epithelial cells, are reported, together with recent work on these structures. The review concludes with an examination of how membrane-skeletal elements could contribute to the membrane transformation.
Airway inflammation in asthma and perennial allergic rhinitis. Relationship with nonspecific bronchial responsiveness and maximal airway narrowing
Authors: M. J. Alvarez, J. M. Olaguibel, B. E. García, A. Rodríguez, A. I. Tabar, E. Urbiola
Journal: Allergy (2000)

Background : Eosinophilic airway inflammation is the hallmark of asthma, but it has also been reported in other conditions such as allergic rhinitis. We have tested whether the analysis of cells and chemicals in sputum can distinguish between patients with mild allergic asthma, those with allergic rhinitis, and healthy controls. The relationship between inflammation markers in sputum and nonspecific bronchial hyperresponsiveness to methacholine (BHR) (PD 20 and maximal response plateau [MRP] values) was also evaluated. Methods : We selected 31 mild asthmatics and 15 rhinitis patients sensitized to house‐dust mite. As a control group, we studied 10 healthy subjects. Every subject underwent the methacholine bronchial provocation test (M‐BPT) and sputum induction. Blood eosinophils and serum ECP levels were measured. Sputum cell differentials were assessed, and eosinophil cationic protein (ECP), tryptase, albumin, and interleukin (IL)‐5 levels were measured in the entire sputum supernatant. Results : Blood eosinophils and serum ECP levels were higher in asthma patients and rhinitis than in healthy controls, but no difference between asthma patients and rhinitis patients was found. Asthmatics had higher eosinophil counts and higher ECP and tryptase levels in sputum than rhinitis patients or control subjects. Sputum albumin levels were higher in asthmatics than in controls. Rhinitis patients exhibited higher sputum eosinophils than healthy controls. An association between sputum eosinophil numbers and MPR values ( r =−0.57) was detected, and a trend toward correlation between sputum ECP levels and PD 20 values ( r =−0.47) was found in the rhinitis group, but not in asthmatics. No correlation between blood eosinophilic inflammation and lung functional indices was found. Conclusions : Induced sputum is an accurate method to study bronchial inflammation, allowing one to distinguish between rhinitis patients and mildly asthmatic patients. The fact that no relationship was detected between sputum inflammation and BHR suggests that other factors, such as airway remodeling, may be at least partly responsible for BHR in asthma.
Helicobacter pylori infection in healthy people: a dynamic process?
Authors: B Meyer, B Werth, C Beglinger, S Dill, J Drewe, W A Vischer, R H Eggers, F E Bauer, G A Stalder
Journal: Gut (1991)

Epidemiological studies using serological tests have shown that a large proportion of healthy people have antibodies against Helicobacter pylori (anti-Hp). It is uncertain whether the presence of anti-Hp indicates active infection or only past exposure to the micro-organism. In this study we determined anti-Hp with a specific enzyme linked immunosorbent assay in 100 healthy volunteers who were at the same time investigated for active H pylori infection by means of the 13C-urea breath test. Forty nine per cent had a high anti-Hp titre, but only 24% had active H pylori infection. Our study suggests that a considerable number of healthy people previously infected with H pylori have spontaneously eliminated this microorganism. We suggest that the inability of ulcer patients to eliminate H pylori may be important in the pathogenesis of peptic ulcer disease.
Hyperaldosteronism, Hyperparathyroidism, Medullary Sponge Kidneys, and Hypertension
Authors: Dorothea E. Hellman
Journal: JAMA (1980)

Hyperparathyroidism and hyperaldosteronism coexisted in association with medullary sponge kidneys in a 27-year-old woman with severe hypertension. A modest fall in systolic and diastolic pressure followed removal of a parathyroid adenoma. Blood pressure was controlled with spironolactone therapy and restored to normal after removal of an aldosterone-secreting adrenal tumor. Elevated levels of aldosterone may have been responsible for the severe hypertension, while hypercalcemia may have had a synergistic effect on the arteriolar response to circulating vasoactive peptides.