tbuckley/cabot-search huggingface dataset:
Haemarthrosis due to fracture through amyloid deposits in bone in Portuguese familial amyloidosis.
Authors: S A Allard, R H King, P K Thomas, B E Bourke
Journal: Annals of the Rheumatic Diseases (1991)

A patient with Portuguese familial amyloid polyneuropathy who developed haemarthroses secondary to pathological fractures is described. Amyloid material was demonstrated on bone biopsy and confirmed immunohistochemically to be transthyretin (prealbumin). Although amyloid deposits in bone have been described in other types of amyloid, this is believed to be the first proved case of amyloid deposition resulting in pathological fracture in familial amyloidosis.
Limitations and Late Complications of Third-Generation Automatic Cardioverter-Defibrillators
Authors: S. O. Nunain, M. Roelke, T. Trouton, S. Osswald, Y. H. Kim, G. Sosa-Suarez, D. R. Brooks, B. McGovern, M. Guy, D. F. Torchiana, G. J. Vlahakes, H. Garan, J. N. Ruskin
Journal: Circulation (1995)

Background This study examines the limitations and complex management problems associated with the use of tiered-therapy, implantable cardioverter-defibrillators (ICDs). Methods and Results The study group comprises the first 154 patients undergoing implantation of tiered-therapy ICDs at our institution. Pulse generators from three different manufacturers were used. In 39 patients, a complete nonthoracotomy lead system was used. The perioperative mortality was 1.3%. Of these 154 patients, 37% experienced late postoperative problems. Twenty-one patients required system revision within 36.5 months (mean, 8.57±11.3) of surgery. Reasons for revision were spurious shocks due to electrode fractures (3) or electrode adapter malfunction (2), inadequate signal from endocardial rate-sensing electrodes (3), superior vena cava or right ventricular coil migration (5), failure to correct tachyarrhythmias due to a postimplant rise in defibrillation threshold (5), or pulse generator failure (3). One of these patients required system removal for infection after revision of an endocardial lead. A further 32 patients received inappropriate shocks for atrial fibrillation with a rapid ventricular response or sinus tachycardia. Two of these patients also received shocks for ventricular tachycardia initiated by antitachycardia pacing triggered by atrial fibrillation. Ventricular pacing for bradycardia was associated with inappropriate shocks due to excessive autogain in 2 patients. Conclusions Despite the major diagnostic and therapeutic advantages of tiered-therapy ICDs, a significant proportion of patients continue to experience hardware-related complications or receive inappropriate shocks.
This Is When It Hurts
Authors: Dawn M. Gross
Journal: Annals of Internal Medicine (2011)

Ad Libitum1 November 2011This Is When It HurtsDawn M. Gross, MD, PhDDawn M. Gross, MD, PhDFrom University of California, San Francisco, San Francisco, CA 94117.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-9-201111010-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This is when it hurtsWhen the sticker on the surfaceOf a non-stick panwon't come off ...When your HMO offers a PPOWith PHI protected by HIPAAand you're lost in translation ...When you, who used to tap your toeAnd roll your eyes at theOne person in your life whoRelished solving these mystifying trialsis no more ...This is when it hurts.When your mother has lost her wayBut righted herself just in timeTo say goodbyeYet hasn't packed her suitcaseFor her trip tonight,the one you used to pack for her ...When ... Author, Article, and Disclosure InformationAuthors: Dawn M. Gross, MD, PhDAffiliations: From University of California, San Francisco, San Francisco, CA 94117.Current Author Address: Dawn M. Gross, MD, PhD, Palliative Care Service, University of California, San Francisco, 521 Parnassus Avenue, Box 0903, San Francisco, CA 94143; e-mail, ajgross@massmed.org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 2011Volume 155, Issue 9 Page: 651-652 Keywords Alveoli Brain Health Insurance Portability and Accountability Act Health maintenance organizations Palliative care Pharynx Preferred provider organizations Taste ePublished: 1 November 2011 Issue Published: 1 November 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Enhanced gastric mucosal leukotriene B4 synthesis in patients taking non-steroidal anti-inflammatory drugs.
Authors: N Hudson, M Balsitis, S Everitt, C J Hawkey
Journal: Gut (1993)

The effects of longstanding non-steroidal anti-inflammatory drug (NSAID) treatment on gastric mucosal synthesis of leukotriene B4 (LTB4), leukotriene C4 (LTC4), and prostaglandin E2 (PGE2) was studied. Gastric antral biopsies in 65 patients with arthritis taking NSAIDs and 23 control patients were taken and eicosanoid concentrations, stimulated by vortex mixing or calcium ionophore, were measured by radioimmunoassay. Median gastric mucosal synthesis of LTB4 was increased in patients taking NSAIDs compared with non-users: (0.9(0.2-2.5) pg/mg v 0 (0-0.6) pg/mg (p &lt; 0.001)). These differences persisted when subgroups of patients were analysed according to Helicobacter pylori colonisation or degree of mucosal injury. Synthesis of LTB4 was strongly associated with the presence of type C (chemical) gastritis. Increased synthesis of LTC4 was associated with Helicobacter pylori colonisation but not NSAID use. Synthesis of PGE2 was decreased in patients taking NSAIDs compared with control patients (p &lt; 0.001). Enhanced gastric mucosal synthesis of LTB4 in patients taking NSAIDs may represent a primary effect of these drugs and could be implicated in the pathogenesis of gastritis and ulceration associated with NSAIDs.
Twenty-four-hour ambulatory blood pressure in shift workers.
Authors: N P Chau, J M Mallion, R de Gaudemaris, E Ruche, J P Siche, O Pelen, G Mathern
Journal: Circulation (1989)

Blood pressure and heart rate of 15 male shift workers were measured every 15 minutes for 24 hours during three work shifts: morning, 4:00 AM to noon; afternoon, noon to 8:00 PM; and night, 8:00 PM to 4:00 AM. For each shift, 24-hour systolic and diastolic blood pressure showed a large "trough" (the low pressure span) and a continuous range of elevated pressure (the high pressure span). Fourier series were used to model the 24-hour blood pressure profiles. A careful examination of the residuals (measured minus predicted pressures) showed that four harmonics were necessary to describe the data accurately. The model enabled localization in each blood pressure profile of the high and low pressure spans that did not coincide with the subject's work and rest periods. The time and slope of blood pressure entering and leaving these spans could also be individually determined. Mean blood pressure during the high pressure span was the same for the three shifts, but mean blood pressure during the low pressure span was lower when the subject worked in the afternoon. During that shift, the systolic blood pressure slopes entering and leaving the low pressure span were steeper than during the two other shifts. The high pressure span was longest during the night shift and shortest during the afternoon shift. Therefore, a change in the working time profoundly perturbed the 24-hour blood pressure profile.(ABSTRACT TRUNCATED AT 250 WORDS)
Utility of the Seattle Heart Failure Model in Patients With Advanced Heart Failure
Authors: Andreas P. Kalogeropoulos, Vasiliki V. Georgiopoulou, Grigorios Giamouzis, Andrew L. Smith, Syed A. Agha, Sana Waheed, Sonjoy Laskar, John Puskas, Sandra Dunbar, David Vega, Wayne C. Levy, Javed Butler
Journal: Journal of the American College of Cardiology (2009)
Women in Labour
Authors: S. Wray
Journal: BMJ (1945)

<h3>Abstract</h3> Existing fish species distribution databases have the following problems: the possibility of species identification errors due to plasticity of morphological characteristics, the impossibility of quantitative composition, and the difficulty of geographically and time-series integrated interpretation. To solve the above problems, we constructed MitoSearch database. It is a fish species distribution database using 2,160 samples of variable regions of 12S rRNA genes amplified by MiFish primers registered at NCBI/EBI/DDBJ, and visualizes the fish species composition data on a map. By integrating a large amount of data registered in public databases, MitoSearch was aimed to provide the comprehensive understanding of spatial and temporal distribution of organisms on a global scale.
Abstract 5166: Characterization of somatic mutation spectrum in gastric cancer cases from Hispanic populations
Authors: Rodrigo Prieto, Paul Lott, Ruta Sahasrabudhe, Mabel Bohorquez, Jorge Castro, Gilbert Mateus, Magdalena Echeverry, Luis G. Carvajal Carmona
Journal: Cancer Research (2014)

Abstract Gastric cancer is the second leading cause of cancer related deaths worldwide. Identification of gastric cancer drivers and somatic changes are essential to understand the molecular basis of tumorigenesis and to develop better preventive and therapeutic strategies. Till date, the large-scale initiatives to characterize somatic changes have been largely limited to Caucasian and Asian populations. This approach is likely to miss potential driver mutations that can be unique to other populations. Therefore, identification of somatic changes in cancers from multi-ethnic populations is essential to advance our understanding of tumor biology as well to bridge the gap in heath-care disparities. Hispanics are the largest and fastest growing minority in the USA and gastric cancer is a significant health care concern in this population. To understand molecular signatures of somatic alterations in gastric cancer in Hispanic population, we performed exome sequencing of 36 tumor samples and matched normal mucosa from gastric cancer patients from Colombia. In addition, we also performed microsatellite instability (MSI) testing and determined Epstein Barr virus and Helicobacter Pylori infection status for these samples. Our preliminary analysis of exome sequencing data by a locally developed pipeline indicates that the frequency of known cancer drivers in our study population in different than that has been reported previously and a subset of these cancers are following unique genetic pathways. In summary, our sequencing efforts in gastric cancer cases from Hispanic population are likely to identify novel cancer drivers and can help to further our understanding of molecular basis of this tumor type. Citation Format: Rodrigo Prieto, Paul Lott, Ruta Sahasrabudhe, Mabel Bohorquez, Jorge Castro, Gilbert Mateus, Magdalena Echeverry, Luis G. Carvajal Carmona. Characterization of somatic mutation spectrum in gastric cancer cases from Hispanic populations. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5166. doi:10.1158/1538-7445.AM2014-5166
Diagnostic Imaging of the Lumbar Spine
Authors: William T. Pochis
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 February 1990Diagnostic Imaging of the Lumbar SpineWilliam T. Pochis, MD, Arthur Z. Krasnow, MD, B. David Collier, MDWilliam T. Pochis, MDSearch for more papers by this author, Arthur Z. Krasnow, MDSearch for more papers by this author, B. David Collier, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-4-310 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Deyo and colleagues (1) recently reviewed the use of diagnostic imaging procedures for evaluation of the lumbar spine. Radionuclide bone imaging was described as being most useful for the early detection of metastatic cancer or spinal infections and having a limited application in the investigation of low back pain. Such has not been the experience at the Affiliated Hospitals of the Medical College of Wisconsin. At our institution, investigation of chronic low back pain is one of the commonest indications for bone scanning.The use of skeletal scintigraphy in the evaluation of low back pain has been...References1. DeyoBigosMaravilla RSK. Diagnostic imaging procedures for the lumbar spine. Ann Intern Med. 1989;111:865-7. LinkGoogle Scholar2. CollierKirMills BKB. Bone scan: a useful test for evaluating patients with low back pain. Skeletal Radiol. [In press]. Google Scholar3. CollierJohnsonCarrera BRG. Painful spondylolysis or spondylolisthesis studied by radiography and single-photon emission computed tomography. Radiology. 1985;154:207-11. CrossrefMedlineGoogle Scholar4. CollierHellmanKrasnow BRA. Bone SPECT. Semin Nucl Med. 1987;17:247-66. CrossrefMedlineGoogle Scholar5. SlizofskiCollierFlatleyCarreraHellmanIsitman WBTGRA. Painful pseudoarthrosis following lumbar spinal fusion: detection by combined SPECT and planar bone scintigraphy. Skeletal Radiol. 1987;16:136-41. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medical College of Wisconsin Milwaukee, WI 53226 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByBildgebende Verfahren in der Rheumatologie: Bildgebung bei degenerativen Erkrankungen der WirbelsäuleBildgebung bei degenerativen Erkrankungen der Wirbelsäule 15 February 1990Volume 112, Issue 4Page: 310-311KeywordsBoneBone imagingDiagnostic imagingLower back painRadionuclide imagingSpine Issue Published: 15 February 1990 PDF DownloadLoading ...
Response to peginterferon alfa-2a (40KD) in HBeAg-negative CHB: On-treatment kinetics of HBsAg serum levels vary by HBV genotype
Authors: Maurizia R. Brunetto, Patrick Marcellin, Beatrice Cherubini, Cihan Yurdaydin, Patrizia Farci, Stephanos J. Hadziyannis, Vivien Rothe, Loredana Regep, Ferruccio Bonino
Journal: Journal of Hepatology (2013)
Infectious disease testing for blood transfusions. NIH Consensus Development Panel on Infectious Disease Testing for Blood Transfusions
Authors: Jf Desforges, F Athari, Es Cooper, Cs Johnson, Sm Lemon, Kl Lindsay, J Mccullough, K Mcintosh, Rk Ross, Cf Whitsett, J Wittes, Tl Wright
Journal: JAMA (1995)

<h3>Objective.</h3> —To provide physicians and other transfusion medicine professionals with a current consensus on infectious disease testing for blood transfusions. <h3>Participants.</h3> —A nonfederal, nonadvocate, 12-member consensus panel representing the fields of hematology, infectious disease, transfusion medicine, epidemiology, and biostatistics and a public representative. In addition, 23 experts in hematology, cardiology, transfusion medicine, infectious disease, and epidemiology presented data to the consensus panel and a conference audience of 450. <h3>Evidence.</h3> —The literature was searched through MEDLINE and an extensive bibliography of references was provided to the panel and the conference audience. Experts prepared abstracts with relevant citations from the literature. Scientific evidence was given precedence over clinical anecdotal experience. <h3>Consensus.</h3> —The panel, answering predefined consensus questions, developed their conclusions based on the scientific evidence presented in open forum and the scientific literature. <h3>Consensus Statement.</h3> —The panel composed a draft statement that was read in its entirety and circulated to the experts and the audience for comment. Thereafter, the panel resolved conflicting recommendations and released a revised statement at the end of the conference. The panel finalized the revisions within a few weeks after the conference. <h3>Conclusions.</h3> —The serum alanine aminotransferase test should be discontinued as a surrogate marker for blood donors likely to transmit posttransfusion non-A, non-B hepatitis infection since specific hepatitis C antibody testing has eliminated more than 85% of these cases. Antibody to hepatitis B core antigen testing should continue as it may prevent some cases of posttransfusion hepatitis B; it may also act as a surrogate marker for human immunodeficiency virus (HIV) infection in donors and may prevent a small number of cases of transfusion-transmitted HIV infection. Syphilis testing should continue until adequate data can determine its effect on the rarity of transfusion-transmitted syphilis. Vigilant public health surveillance is critical in responding to emerging infectious disease threats to the blood supply. (<i>JAMA</i>. 1995;274:1374-1379)
Exposure to bacterial products renders macrophages highly susceptible to T-tropic HIV-1.
Authors: M Moriuchi, H Moriuchi, W Turner, A S Fauci
Journal: Journal of Clinical Investigation (1998)

Microbial coinfections variably influence HIV-1 infection through immune activation or direct interaction of microorganisms with HIV-1 or its target cells. In this study, we investigated whether exposure of macrophages to bacterial products impacts the susceptibility of these cells to HIV-1 of different cellular tropisms. We demonstrate that () macrophages exposed to bacterial cell wall components such as lipopolysaccharide (LPS) (Gram-negative rods), lipoteichoic acid (Gram-positive cocci), and lipoarabinomannan (Mycobacteria) become highly susceptible to T cell (T)-tropic HIV-1 (which otherwise poorly replicate in macrophages) and variably susceptible to macrophage (M)-tropic HIV-1; () LPS-stimulated macrophages secrete a number of soluble factors (i.e., chemokines, interferon, and proinflammatory cytokines) that variably affect HIV infection of macrophages, depending on the virus phenotype in question; and () LPS-stimulated macrophages express CCR5 (a major coreceptor for M-tropic HIV-1) at lower levels and CXCR4 (a major coreceptor for T-tropic HIV-1) at higher levels compared with unstimulated macrophages. We hypothesize that a more favorable environment for T-tropic HIV-1 and a less favorable or even unfavorable environment for M-tropic HIV-1 secondary to exposure of macrophages to those bacterial products may accerelate a transition from M- to T-tropic viral phenotype, which is indicative of disease progression.
ABO Blood Groups and Secretor Character in Duodenal Ulcer
Authors: C. A. Clarke, J. W. Edwards, D. R. W. Haddock, A. W. Howel-Evans, R. B. McConnell, P. M. Sheppard
Journal: BMJ (1956)

In a previous paper (Clarke et al., 1955) we showed in a survey of 1,665 peptic ulcer cases drawn from three Liverpool hospitals that there was a great increase in blood group 0 in patients with duodenal ulcer com- pared with controls ; in gastric ulcer, on the other hand, the ABO distribution was normal.The investigations had been prompted by the earlier paper of Aird et al. (1954), which demonstrated, in three other English centres, a marked increase in blood group 0 in bo!h- duodenal and gastric ulcer compared with controls.The high frequency of group 0 in peptic ulcer has also been reported by workers in Portugal (Lessa and Alarcao,
Abstract 2433: Metabolic reprogramming by an epigenetic mechanism in endocrine therapy resistance of breast cancer
Authors: June X. Zou, Junjian Wang, Zhijian Duan, Hongwu Chen, Hsing-Jien Kung, Xinbin Chen, Leigh C. Murphy, Alexander Borowsky
Journal: Cancer Research (2014)

Abstract Metabolic reprogramming is a major mechanism of fueling cancer cell growth and proliferation. However, how tumor metabolism is altered to confer therapeutic resistance is poorly understood. Gene expression profiling of tamoxifen sensitive and resistant breast cancer cells revealed that transition to the resistance was associated with a specific expression reprogramming of genes involved in glucose/energy metabolism, which was accompanied by aberration of specific epigenetic regulators such as the histone methyltransferase NSD2/MMSET/WHSC1. In cell and xenograft tumor models, NSD2 overexpression alone was sufficient to confer tamoxifen resistance. Analysis of clinical specimens indicates that NSD2 was a strong predictive factor for early relapse of tamoxifen therapy. NSD2 wild type, but not its methylase-defective mutant form, coordinately stimulated the expression and enzymatic activity of HK2, TIGAR and G6PD and strongly augmented the pentose phosphate pathway (PPP) production of NADPH for ROS reduction and survival of tamoxifen treated cells and tumors. Further mechanistic studies demonstrated that elevated NSD2 stimulates the metabolic gene expression through H3K36 methylation at the target chromatin. Pharmacological targeting aberrant NSD2 by DZNeP, an S-adenosylhomocysteine (AdoHcy) hydrolase inhibitor, effectively blocked the growth of tamoxifen-resistant tumor. The study reveals a novel mechanism of cancer metabolic reprogramming and suggests targeting the key metabolic re-programmer as a viable option for effective treatment of endocrine resistant tumors. Note: This abstract was not presented at the meeting. Citation Format: June X. Zou, Junjian Wang, Zhijian Duan, Hongwu Chen, Hsing-Jien Kung, Xinbin Chen, Leigh C. Murphy, Alexander Borowsky. Metabolic reprogramming by an epigenetic mechanism in endocrine therapy resistance of breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2433. doi:10.1158/1538-7445.AM2014-2433
Breast Uptake of Ga-67 in a Neonate
Authors: KEMAN FIRMAN, ROBERT HOWMAN-GILES
Journal: Clinical Nuclear Medicine (1992)

A 6-day-old baby boy showed concentration of Ga-67 citrate in both breasts and an abdominal neuroblastoma. The breast uptake was most likely caused by estrogen and prolactin production and passage from the maternal to the fetal circulation.
The proportion of true cases of autism is not changing
Authors: T. S. Brugha, S. McManus, J. Bankart, R. Jenkins, J. Smith, F. Scott
Journal: BMJ (2014)

Blenner and Augustyn state that the Centers for Disease Control and Prevention (CDC) study design cannot answer the question of whether autism spectrum disorder is increasing.1 We agree, but we do not agree with the implication that such evidence does …
RECURRENCE OF URINARY OBSTRUCTION AFTER PROSTATECTOMY
Authors: F. M. DENSLOW
Journal: JAMA (1918)

In the past few months I have had occasion to reoperate in five cases of prostatic obstruction in which a suprapubic prostatectomy had previously been done. One of these cases was one in which I, myself, had operated. The other operations had been done by men of experience in Kansas City and elsewhere. In two of the cases I assisted the original operator to correct the secondary obstruction. The usual history of these patients was of their having made a good recovery from the operation, of having left the hospital in good condition in from four to six weeks, voiding urine well and being apparently cured. From that time on, the size of the stream would progressively diminish, and it would become more difficult to void. Finally the suprapubic wound would reopen and remain open, and the passage through the urethra become closed, or nearly so. In the case in
PRS-03: Phase III study of pemetrexed plus cisplatin versus gemcitabine plus cisplatin in chemonaive patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)
Authors: Giorgio Scagliotti, Parikh Purvish, Joachim von Pawel, Bonne Biesma, Johan Vansteenkiste, Christian Manegold, Lorinda Simms, Katherine Posther Sugarman, Coleman Obasaju, Johannes Blatter
Journal: Journal of Thoracic Oncology (2007)
Distribution of atrial electrogram types during atrial fibrillation: Effect of rapid atrial pacing and intercaval junction ablation
Authors: Huagui Li, John Hare, Kashef Mughal, David Krum, Michael Biehl, Sanjay Deshpande, Anwer Dhala, Zalmen Blanck, Jasbir Sra, Mohammad Jazayeri, Masood Akhtar
Journal: Journal of the American College of Cardiology (1996)