Risk for Non-A, Non-B (Type C) Hepatitis through Sexual or Household Contact with Chronic Carriers
Authors: James E. Everhart
Journal: Annals of Internal Medicine (1990)

Brief Reports1 April 1990Risk for Non-A, Non-B (Type C) Hepatitis through Sexual or Household Contact with Chronic CarriersJames E. Everhart, MD, Adrian M. Di Bisceglie, MD, Linda M. Murray, RN, Harvey J. Alter, MD, Jacqueline J. Melpolder, MT, George Kuo, PhD, Jay H. Hoofnagle, MDJames E. Everhart, MD, Adrian M. Di Bisceglie, MD, Linda M. Murray, RN, Harvey J. Alter, MD, Jacqueline J. Melpolder, MT, George Kuo, PhD, Jay H. Hoofnagle, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-7-544 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTransmission of non-A, non-B hepatitis through parenteral exposures, including drug abuse, blood transfusion, and occupational injury with a needle contaminated with blood is well documented (1). Other means of non-A, non-B hepatitis transmission must occur, since at least 50% of patients do not have a history of parenteral exposure (2, 3). Personal contact as a route of infection has been reported (4), but not shown conclusively, and the actual risk for such transmission is unknown.Recently, the genome of the hepatitis C virus (HCV), the major agent that causes non-A, non-B hepatitis, has been isolated (5). Antibody to hepatitis C...References1. Dienstag J. Non-A, non-B hepatitis. I. Recognition, epidemiology, and clinical features. Gastroenterology. 1983;85:439-62. CrossrefMedlineGoogle Scholar2. AlterGeretySmallwood MRL. Sporadic non-A, non-B hepatitis: frequency and epidemiology in an urban U.S. population. J Infect Dis. 1982;145:886-93. CrossrefMedlineGoogle Scholar3. AlterMaresHadlerMaynard MASJ. The effect of underreporting on the apparent incidence and epidemiology of acute viral hepatitis. Am J Epidemiol. 1987;125:133-9. CrossrefMedlineGoogle Scholar4. AlterColemanAlexander MPW. Importance of heterosexual activity in the transmission of hepatitis B and non-A, non-B hepatitis. JAMA. 1989;262:1201-5. CrossrefMedlineGoogle Scholar5. ChooKuoWeinerOverbyBradleyHoughton QGALDM. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science. 1989;244:359-62. CrossrefMedlineGoogle Scholar6. KuoChooAlter GQH. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science. 1989;244:362-4. CrossrefMedlineGoogle Scholar7. Di BisceglieMartinKassianides APC. Recombinant interferon alfa therapy for chronic hepatitis C: a randomized, double blind, placebo-controlled trial. N Engl J Med. 1989;321:1506-10. CrossrefMedlineGoogle Scholar8. AlterPurcellHollandAllingKoziol HRPDD. Donor transaminase and recipient hepatitis. Impact on blood transfusion services. JAMA. 1981;246:630-4. CrossrefMedlineGoogle Scholar9. Armitage P. Statistical Methods in Medical Research. Oxford: Blackwell Scientific Publications; 1971:111-2. Google Scholar10. KahnJohnsonAachHinesEllisMiller RGRAFW. The distribution of serum alanine aminotransferase levels in a blood donor population. Am J Epidemiol. 1982;115:929-40. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the National Institutes of Health, Bethesda, Maryland; and the Chiron Corporation, Emeryville, California. For current author addresses, see end of text. 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