Transplants from the Same Donor
Authors: T. R. Spitzer, J. Zwiebel, R. J. Jacobson
Journal: Annals of Internal Medicine (1991)

Letters15 September 1991Transplants from the Same DonorT. R. Spitzer, MD, J. Zwiebel, MD, R. J. Jacobson, MDT. R. Spitzer, MDSearch for more papers by this author, J. Zwiebel, MDSearch for more papers by this author, R. J. Jacobson, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-6-498_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Sayegh and colleagues (1) described the induction of allotolerance to renal allografts in two patients who had previously received bone marrow transplants from the same donors. We report what we believe to be the first case of a patient receiving an HLA-matched bone marrow transplant after a solid organ transplant (renal allograft) from the same donor. The post-transplant course, which was characterized by treatment-refractory, lethal graft-versus-host disease, suggests that host immune status (in this case, influenced by chronic antigenic stimulation from the previous allograft) played an important role in the pathogenesis of graft-versus-host disease.A 42-year-old man...References1. Sayegh M, Fine N, Smith J, Rennke H, Milford E, and Tilney N. Immunologic tolerance to renal allografts after bone marrow transplants from the same donors. Ann Intern Med. 1991;114:954-5. LinkGoogle Scholar2. Storb R, Epstein R, Rudolph R, and Thomas E. The effect of prior transfusion on marrow grafts between histocompatible canine siblings. J Immunol. 1970:105:627. CrossrefMedlineGoogle Scholar3. Popitz-Bergez F, Sakamoto K, Pennington L, Peskovitz M, McDonough M, and MacVittie T. Bone marrow transplantation in miniature swine II. Effect of selective genetic differences on marrow engraftment and recipient survival. Transplantation. 1988:45:27. CrossrefMedlineGoogle Scholar4. Hill R, Petersen R, Storb R, Appelbaum F, Doney K, and Dahlberg S. Mixed hematologic chimerism after allogeneic marrow transplantation for severe aplastic anemia is associated with a higher risk of rejection and a lesser incidence of graft-versus-host disease. Blood. 1986;67:811-816. CrossrefMedlineGoogle Scholar5. Spitzer T, Himoe E, Cottier-Fox M, Cahill R, and Deeg H. Long-term stable mixed chimerism following allogeneic marrow transplantation for severe aplastic anemia. Br J Haematol. 1990;76:146-154. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: T. R. Spitzer, MD; J. Zwiebel, MD; R. J. Jacobson, MDAffiliations: Georgetown University Hospital Washington, DC 20007 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHematopoietic Cell Transplantation after Solid Organ TransplantationRenal Graft Rejection After Allogeneic Peripheral-Blood Stem Cell TransplantationShould we be performing more combined hematopoietic stem cell plus solid organ transplants?Discontinuation of immunosuppression for prevention of kidney graft rejection after receiving a bone marrow transplant from the same HLA identical sibling donorOutcomes of Recipients of Both Bone Marrow and Solid Organ Transplants: A ReviewCase 19-1996Transplants from the Same DonorD. H. Vesole, MD, PhD, S. Jagannath, MD 15 September 1991Volume 115, Issue 6Page: 498-498KeywordsAntigensBone marrowPathogenesisRenal transplantation ePublished: 1 December 2008 Issue Published: 15 September 1991 PDF downloadLoading ...