tbuckley/cabot-search huggingface dataset:
Comparison of Long-Term Outcomes of Atrial Repair of Simple Transposition With Implications for a Late Arterial Switch Strategy
Authors: D. Sarkar, C. Bull, R. Yates, D. Wright, S. Cullen, M. Gewillig, R. Clayton, A. Tunstill, J. Deanfield
Journal: Circulation (1999)

We report the single-institution, long-term results of 358 patients with simple transposition of the great arteries surviving >30 days after a Mustard (n=226, 1965 to 1980) or Senning (n=132, 1978 to 1992) procedure.Outcome measures included late death, reintervention, ECG and ambulatory ECG rhythm, new arrhythmia, and functional status. Average follow-up was 13.4 (range 0.32 to 17.9) years for the Senning group and 11.7 (range 0.04 to 23.9) years for the Mustard group. The Senning group had a better survival rate at 5, 10, and 15 years (95% versus 86%, 94% versus 82%, and 94% versus 77%, respectively). In both groups, the majority of late deaths were sudden, without preceding ventricular dysfunction. Survival and survival free of reintervention were significantly better in the Senning group (relative risk [RR] 0.34, P=0.06 versus RR 0.39, P=0.027). Loss of sinus rhythm was comparable and unrelated to death. After era correction, the incidence of atrial flutter was similar and strongly associated with late death in both groups. Clinical systemic ventricular failure was uncommon, and at last follow-up, 92% of the Senning group and 89% of the Mustard group were in New York Heart Association class I. In a model exploring the implications of elective arterial switch conversion, this would only be beneficial if the hazard late after switch was markedly reduced and/or the hazard after the Senning procedure increased with time.Late outcomes after the Senning procedure are superior to those after the Mustard procedure. Both groups had late sudden deaths that were not associated with clinical systemic ventricular failure. Good functional status after the Senning procedure suggests that a strategy of elective switch conversion cannot be justified for patients with isolated transposition.
Human antiglomerular basement membrane autoantibody disease in XenoMouse II11See Editorial by Borza and Hudson, p. 1905.
Authors: Kevin E.C. Meyers, Juanita Allen, Jeffrey Gehret, Aya Jacobovits, Michael Gallo, Eric G. Neilson, Helmut Hopfer, Raghu Kalluri, Michael P. Madaio
Journal: Kidney International (2002)
Severe coagulation factor V deficiency caused by 2 novel frameshift mutations: 2952delT in exon 13 and 5493insG in exon 16 of factor 5 gene
Authors: Éva Ajzner, István Balogh, Teréz Szabó, Anikó Marosi, Gizella Haramura, László Muszbek
Journal: Blood (2002)
Drugs arriving in Kosovo need checking
Authors: G. L. Quaglio, P. Mezzelani, C. Cuchillo
Journal: BMJ (1999)

EDITOR—3As deputy head and consultants of the health department of EUAM (European Union Administration of Mostar) in 1995-6 we were impressed by Saunders's article concerning drug donations.1 In Bosnia these problems appeared for a variety of complex reasons that have been widely recognised.2–4 The problem of private donations in former Yugoslavia was exacerbated by the country's proximity to the countries of the European Community. Though drugs arrived quickly and inexpensively, they arrived unchecked …
Pancytopenia due to bone marrow necrosis in acute myelogenous leukemia: Role of reactive CD8 cells
Authors: S. N. Markovic, R. L. Phyliky, C. Y. Li
Journal: American Journal of Hematology (1998)

Bone marrow necrosis is a rare clinical condition often associated with hematological malignancy. The mechanism by which malignant disease causes marrow necrosis is unknown. We present a case of a patient with newly diagnosed pancytopenia with bone marrow biopsy evidence of extensive marrow necrosis. Upon further work-up utilizing Tc bone scan directed bone marrow biopsy, a massive CD8+ T cell marrow infiltrate was discovered engulfing AML-M2 blasts. The role of Tc bone scans in the work-up of bone marrow necrosis as well as the potential mechanism of AML-M2 induced marrow necrosis in the setting of reactive CD8+ T cell infiltration is discussed. Am. J. Hematol. 59:74– 78, 1998. © 1998 Wiley-Liss, Inc.
Management of Mediastinal Relapse after Treatment with Stereotactic Body Radiotherapy or Accelerated Hypofractionated Radiotherapy for Stage I/II Non–Small-Cell Lung Cancer
Authors: Jeremy M. Kilburn, Scott C. Lester, John T. Lucas, Michael H. Soike, A. William Blackstock, William T. Kearns, William H. Hinson, Antonius A. Miller, William J. Petty, Michael T. Munley, James J. Urbanic
Journal: Journal of Thoracic Oncology (2014)
Specific IgE and IgG to gelatin in children with systemic cutaneous reactions to Japanese encephalitis vaccines
Authors: M. Sakaguchi, H. Miyazawa, S. Inouye
Journal: Allergy (2001)

Background: Systemic allergic reactions to Japanese encephalitis (JE) vaccine that include urticaria, angioedema, and rash have been reported. In Japan, children who suffered from allergic immediate‐type reactions to JE vaccine had antigelatin IgE in their sera. However, the immunologic mechanism of allergic nonimmediate‐type reactions that consist of cutaneous signs appearing several hours or more after JE vaccination has not been defined. Methods: Serum samples were taken from 28 children who showed allergic nonimmediate‐type cutaneous reactions to JE vaccine. Furthermore, serum samples were taken from 10 children who showed allergic immediate‐type reactions with cutaneous signs and/or respiratory symptoms to JE vaccine. We have defined an immediate‐type reaction as one occurring within 1 h after vaccination. Results: Of 10 children who showed immediate‐type reactions, all had antigelatin IgE and IgG. Of 28 children who showed systemic nonimmediate‐type reactions, one had antigelatin IgE and nine (32%) had antigelatin IgG. The child who had antigelatin IgE showed urticaria 2 h after JE vaccination. Conclusions: These results suggest that some children who showed allergic nonimmediate‐type reactions to JE vaccine were sensitized to gelatin.
Prevalence and predictors of hepatitis B virus coinfection in a United States cohort of hepatitis C virus-infected patients
Authors: Gia L. Tyson, Jennifer R. Kramer, Zhigang Duan, Jessica A. Davila, Peter A. Richardson, Hashem B. El-Serag
Journal: Hepatology (2013)

There are sparse epidemiologic data on coinfection of hepatitis B (HBV) and hepatitis C (HCV) in the United States. Therefore, the aim of this study was to determine the prevalence and predictors of HBV coinfection in a large U.S. population of HCV patients. We used the National Veterans Affairs HCV Clinical Case Registry to identify patients tested for HCV during 1997-2005. Patients were categorized based on HCV exposure (any two +HCV tests or one test with a diagnostic code), HCV infection (+RNA or genotype), HBV exposure (any +HBV test, excluding +HBsAb only), and HBV infection (+HBsAg, HBV DNA, or HBeAg). The prevalence of HBV exposure among patients with HCV exposure and that of HBV infection among patients with HCV infection were determined. Multivariate logistic regression evaluated potential demographic and clinical predictors of HBV coinfection. Among 168,239 patients with HCV exposure, 58,415 patients had HBV exposure for a prevalence of 34.7% (95% confidence interval [CI] 34.5-35.0). Among 102,971 patients with HCV infection, 1,431 patients had HBV coinfection for a prevalence of 1.4% (95% CI 1.3-1.5). Independent associations with HBV coinfection compared with HCV monoinfection were age ≤50 years, male sex, positive HIV status, history of hemophilia, sickle cell anemia or thalassemia, history of blood transfusion, cocaine and other drug use; there was decreased risk in patients of Hispanic ethnicity. Conclusion : This is the largest cohort study in the U.S. on the prevalence of HBV coinfection in HCV patients. Among veterans with HCV, exposure to HBV is common (˜35%), but HBV coinfection is relatively low (1.4%). Several possible risk factors were identified. (Hepatology 2013;58:538–545)
Abstract 2042: Deregulated TS promotes tumor progression in diverse hematopoietic and mesenchymal cell lineages
Authors: Min Chen, Akbar Nawab, Frederic J. Kaye, Maria Zajac-Kaye
Journal: Cancer Research (2014)

Abstract Our laboratory recently showed that elevated TS plays a direct causal role in tumorigenesis of NIH3T3 cells in vitro and in the development of endocrine pancreatic mouse tumors in vivo. This observation changed the paradigm of TS as a passive biomarker and has significance for cancer treatment as it refocuses attention on the importance of TS as a tumor-promoting signal. To address whether TS plays an early role in tumorigenesis that is restricted to specific tumor types or if TS plays a late role associated with enhanced progression of established tumors of diverse histologic origin, we have now cross-bred human TS (hTS) transgenic mice with Ink4a/Arf null mice, a common somatic mutation frequently found in adult human cancers. Median survival of hTS/Ink4a/Arf+/- (n=15) mice was reduced 24% (313 vs. 411 days, p &amp;lt;0.05). Both hTS/Ink4a/Arf+/- and hTS/Ink4a/Arf-/- mice (n=16) showed an increase in lymphoma, histiocytic sarcoma (HS) and soft tissue sarcoma (SS). For example, the incidence of HS in hTS/Ink4a/Arf-/- male mice was 31% versus 12% in Ink4a/Arf-/- minus (p&amp;lt;0.01), and tumor cells had spread to multiple tissues (as many as 9 different organs) as compared to hTS minus mice where tumors were localized in lymph nodes and spleen. Strikingly, the tumor burden was markedly increased in hTS/Ink4a/Arf-/- mice: average spleen weight 1.11 vs. 0.49 g, p&amp;lt;0.001, lymph nodes, 1.06 g vs. 0.42 g, p&amp;lt;0.001. We also detected an increase in size and extent of tumor mass of SS (average weight 5.8 g). We detected increased aneuploidy in hTS/Ink4a/Arf-/- HS cell lines as compared to Ink4a/Arf-/- HS cell lines: chromosomal loss 32.1% vs. 16.7%, p&amp;lt;0.05, gain 24.5% vs. 0%, p&amp;lt;0.001 and translocations 9.4% vs. 0%, p&amp;lt;0.05 by spectral karyotyping analysis. Treatment of TS positive HS tumor cells with lenti-TS shRNAs downregulated TS expression and resulted in tumor growth inhibition in vitro as well as in mouse orthotopically transplanted xenograft. In addition, combined TS shRNAs with gemcitabine or pemetrexed treatment showed synergistic inhibition of HS tumor cell growth. These data demonstrate that deregulated TS enhanced genome instability and promote tumor progression in diverse hematopoietic and mesenchymal tumor cells. Citation Format: Min Chen, Akbar Nawab, Frederic J. Kaye, Maria Zajac-Kaye. Deregulated TS promotes tumor progression in diverse hematopoietic and mesenchymal cell lineages. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2042. doi:10.1158/1538-7445.AM2014-2042
Improving the Treatment of Necrotizing Pancreatitis — A Step Up
Authors: Andrew L. Warshaw
Journal: New England Journal of Medicine (2010)

Acute pancreatitis in most patients is self-limited and resolves without complications or the need for invasive procedures or surgical intervention. In a minority of patients, perhaps 10%, necrosis of the pancreatic and peripancreatic tissues opens the door to multiple organ failure, infection of the necrotic tissue, or both, with a greatly increased risk of death; this risk has been estimated to be 20 to 30%. Recent reports citing a substantial reduction in the rate of death, ranging as low as 4%,1,2 attribute the improvement to better intensive care; avoidance of early intervention to allow resuscitation, stabilization, and demarcation and . . .
Exercise treadmill testing is a poor predictor of anatomic restenosis after angioplasty for acute myocardial infarction.
Authors: M B Honan, J R Bengtson, D B Pryor, D S Rendall, R S Stack, T Hinohara, T N Skelton, R M Califf, M A Hlatky, D B Mark
Journal: Circulation (1989)

This study evaluated whether an exercise treadmill test could predict restenosis in 289 patients 6 months after a successful emergency angioplasty of the infarct-related artery for acute myocardial infarction. After excluding those with interim interventions (64), medical events (36), or medical contraindications to follow-up testing (25), both a treadmill test and a cardiac catheterization were completed in 144 patients, 88% of those eligible for this assessment. Four patients with left bundle branch block or pacemaker rhythm at the time of treadmill testing were also excluded from analysis. Of six follow-up clinical and treadmill variables examined by multivariable logistic regression analysis, only exercise ST deviation was independently correlated with restenosis at follow-up (chi 2 = 5, p = 0.02). The clinical diagnosis of angina at follow-up, although marginally related to restenosis when considered by itself (p = 0.04), did not add significant information once ST deviation was known. The sensitivity of ST deviation of 0.10 mV or greater for detecting restenosis was only 24% (13 of 55 patients), and the specificity was 88% (75 of 85 patients). The sensitivity of exercise-induced ST deviation for detection of restenosis was not affected by extent or severity of wall motion abnormalities at follow-up, by the timing of thrombolytic therapy or of angioplasty, or by the presence of collateral blood flow at the time of acute angiography. A second multivariable analysis evaluating the association of the same variables with number of vessels with significant coronary disease at the 6-month catheterization found an association with both exercise ST deviation (p = 0.003) and exercise duration (p = 0.04). Angina symptoms and exercise treadmill test results in this population had limited value for predicting anatomic restenosis 6 months after emergency angioplasty for acute myocardial infarction.
A CASE OF PENTOSURIA OF THIRTEEN YEARS' STANDING
Authors: S. R. SALZMAN
Journal: JAMA (1934)

In their article on pentosuria with a report of twelve cases, Enklewitz and Lasker 1 called attention to the infrequency with which this diagnosis is made. These authors give a summary of the diagnostic data together with chemical studies of the pentose bodies.  The point of interest in the case reported here is the known presence in the urine of a reducing substance for a period of thirteen years, which was finally shown to be pentose. Except for the presence of this reducing body in the urine, the patient is in excellent health.  REPORT OF CASE  F. M. S., a girl, aged 17 years, of Jewish parentage, was 5 feet 3½ inches (161 cm.) tall and weighed 115 pounds (52 Kg.). Except for whooping cough at 16 months, she was in good health until the age of 4½ years, when persistent infection in the tonsils resulted in their removal. At
Therapy Dose Calculation in Graves' Disease Using Early I-123 Uptake Measurements
Authors: USHA S. VEMULAKONDA, FRANCIS B. ATKINS, HARVEY A. ZIESSMAN
Journal: Clinical Nuclear Medicine (1996)

A retrospective study was performed to assess the feasibility of using the 4-hour I-123 early uptake value in the calculation of the treatment dose of radioactive iodine in Graves' disease patients. The Graves' disease patients were randomly divided into two groups. Data from the first group of 35 patients were used to obtain a regression relationship between the early 4-hour uptake (EUp) and 24-hour late uptake values (LUp). This equation, LUp = -38.618 + 65.216 Log (EUp) was used to estimate the predicted late uptake (PUp) from (EUp) in the second group of 34 patients. LUp was used to calculate the I-131 therapy dose for treatment in these patients. In 28 clinically euthyroid patients, the 4-hour uptake I-123 radioactive iodine uptake (RAIU) ranged from 7% to 20% (mean, 12 ± 3.5%). In 60 Graves' disease patients, the 4-hour RAIU ranged from 15% to 100% (mean, 57 ± 24.8%). Of these, there were five patients with a normal 4-hour uptake, but elevated 24-hour uptake. LUp correlated well with PUp (r = 0.81162), as did the dose calculation based on predicted and observed 24-hour uptake values (r = 0.82204). Thus, same day measurement of uptake and treatment of Graves' disease is feasible.
High prevalence of bronchial hyperresponsiveness and asthma in ice hockey players
Authors: JD Leuppi, M Kuhn, C Comminot, WH Reinhart
Journal: European Respiratory Journal (1998)

The prevalence of asthma was studied in a ice hockey team compared with both a floor ball team and the Swiss population. Lung function, bronchial hyperresponsiveness to methacholine, asthma symptoms and exercise-induced asthma were measured in a cross-sectional prospective study. A positive response to the methacholine bronchial provocation test was found in 34.6% of the ice hockey players and 20.8% of the floor ball players (Swiss population 16.4%). The provocative dose causing a 20% fall in the forced expiratory volume in one second (PD20) was significantly lower in ice hockey players than in floor ball players, but there was no significant difference in the dose-response slopes between the two groups. Asthma was diagnosed in 19.2% of the ice hockey players and in 4.2% of the floor ball players (Swiss population 6.8%), whereas exercise-induced asthma was found in 11.5% of the ice hockey players and in 4.2% of the floor ball players. In conclusion, asthma and bronchial hyperresponsiveness seemed to be more common in ice hockey players than in floor ball players and in the Swiss population. Strenuous exercise at lower temperatures may be a risk factor for the higher prevalence of asthma and bronchial hyperresponsiveness, as well as the increased severity of bronchial hyperresponsiveness, particularly in ice hockey players.
Pectus Excavatum Is Part of the Clinical Spectrum of HNF1B MODY5
Authors: Danièle Dubois-Laforgue, Christine Bellanné-Chantelot, Jean-François Subra, José Timsit
Journal: Diabetes Care (2014)

HNF1B maturity-onset diabetes of the young (MODY) (previously named MODY5) is a syndrome due to heterozygous molecular anomalies of the hepatocyte nuclear factor (HNF)1B that may associate diabetes, morphological and functional abnormalities of the kidneys and of the pancreas, liver test anomalies, and genital tract malformations (1,2). MODY5 is due to HNF1B point mutations in half the cases, and is associated to a chromosome 17q12 deletion encompassing the HNF1B gene in the other half (3,4).

Pectus excavatum (PE) is the most frequent anterior chest wall deformity. It has been described as an isolated anomaly or as part of many genetic syndromes, including monogenic diseases and chromosome …
Cortical hand bone loss after 1 year in early rheumatoid arthritis predicts radiographic hand joint damage at 5-year and 10-year follow-up
Authors: M Hoff, G Haugeberg, S Ødegård, S Syversen, R Landewé, D van der Heijde, T K Kvien
Journal: Annals of the Rheumatic Diseases (2008)

To examine 1-year hand bone loss in early rheumatoid arthritis (RA) as a predictor of radiographic damage at 5-year and 10-year follow-upA total of 136 patients with RA (disease duration 0-4 years) were followed for 10 years with clinical data and hand radiographs. Joint damage was scored according to the van der Heijde modification of the Sharp method (vdH Sharp score) and hand bone mineral density (BMD) was measured by digital x ray radiogrammetry (DXR). Group comparisons, correlation analyses and multivariate analyses were performed to evaluate the relationship between hand bone loss and radiographic joint damage.Patients with hand BMD loss at 1 year had a higher median increase in vdH Sharp score compared to patients without loss at 5 years (12 vs 2, p = 0.001) and 10 years (22 vs 4, p = 0.002). In a linear regression model adjusting for age, gender, baseline C-reactive protein (CRP), anti-cyclic citrullinated peptide (CCP), IgM rheumatoid factor (RF) and radiographic damage, absolute hand DXR-BMD loss at 1 year was an independent predictor of radiographic outcome at 5 years (p<0.01) and 10 years (p = 0.02). In a logistic regression model the odds ratio (95% CI) for radiographic progression among patients with hand BMD loss was 3.5 (1.4 to 8.8) and 3.5 (1.4 to 8.4) at 5 and 10 years, respectively.Early hand bone loss measured by DXR-BMD is an independent predictor of subsequent radiographic damage. Our findings support that quantitative hand bone loss in RA precedes radiographic joint damage and may be used as a tool for assessment of bone involvement in RA.
Urban Tree Canopy and Asthma, Wheeze, Rhinitis, and Allergic Sensitization to Tree Pollen in a New York City Birth Cohort
Authors: Gina S. Lovasi, Jarlath P.M. O’Neil-Dunne, Jacqueline W.T. Lu, Daniel Sheehan, Matthew S. Perzanowski, Sean W. MacFaden, Kristen L. King, Thomas Matte, Rachel L. Miller, Lori A. Hoepner, Frederica P. Perera, Andrew Rundle
Journal: Environmental Health Perspectives (2013)

Urban landscape elements, particularly trees, have the potential to affect airflow, air quality, and production of aeroallergens. Several large-scale urban tree planting projects have sought to promote respiratory health, yet evidence linking tree cover to human health is limited.We sought to investigate the association of tree canopy cover with subsequent development of childhood asthma, wheeze, rhinitis, and allergic sensitization.Birth cohort study data were linked to detailed geographic information systems data characterizing 2001 tree canopy coverage based on LiDAR (light detection and ranging) and multispectral imagery within 0.25 km of the prenatal address. A total of 549 Dominican or African-American children born in 1998-2006 had outcome data assessed by validated questionnaire or based on IgE antibody response to specific allergens, including a tree pollen mix.Tree canopy coverage did not significantly predict outcomes at 5 years of age, but was positively associated with asthma and allergic sensitization at 7 years. Adjusted risk ratios (RRs) per standard deviation of tree canopy coverage were 1.17 for asthma (95% CI: 1.02, 1.33), 1.20 for any specific allergic sensitization (95% CI: 1.05, 1.37), and 1.43 for tree pollen allergic sensitization (95% CI: 1.19, 1.72).Results did not support the hypothesized protective association of urban tree canopy coverage with asthma or allergy-related outcomes. Tree canopy cover near the prenatal address was associated with higher prevalence of allergic sensitization to tree pollen. Information was not available on sensitization to specific tree species or individual pollen exposures, and results may not be generalizable to other populations or geographic areas.
Peptic ulceration of the oesophagus following corrosive burns
Authors: J. Imre, G. Wooler
Journal: Thorax (1969)

Ten cases of combined corrosive and peptic strictures of the oesophagus have been described. The peptic stricture of the oesophagus occurred 20 to 50 years after the corrosive burn. The authors believe that the hiatal hernia was due to the contraction of the fibrotic wall of the oesophagus, and therefore they prefer to call it a traction hiatal hernia. The operation of choice in these cases is the resection of the fibrotic oesophagus and replacement by jejunal loop or colic segment. There has been no mortality in this series of 10 patients.
Hunting for consciousness in the brain: What is (the name of) the game?
Authors: José-Luis Díaz
Journal: Behavioral and Brain Sciences (1995)

Abstract Robust theories concerning the connection between consciousness and brain function should derive not only from empirical evidence but also from a well grounded inind-body ontology. In the case of the comparator hypothesis, Gray develops his ideas relying extensively on empirical evidence, but he bounces irresolutely among logically incompatible metaphysical theses which, in turn, leads him to excessively skeptical conclusions concerning the naturalization of consciousness.