Thymoma, Myasthenia Gravis, and Relapsing Polychondritis
Authors: John A. Conti
Journal: Annals of Internal Medicine (1988)

Brief Reports15 July 1988Thymoma, Myasthenia Gravis, and Relapsing PolychondritisJohn A. Conti, MD, Alan R. Colicchio, MD, Leslie M. Howard, MDJohn A. Conti, MD, Alan R. Colicchio, MD, Leslie M. Howard, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-2-163 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe association of thymoma with myasthenia gravis is well established (1). We describe a patient in whom thymoma and myasthenia gravis occurred together with relapsing polychondritis. This is the first association of relapsing polychondritis with thymoma, myasthenia gravis, or both.A 64-year-old white man was hospitalized in December 1985 with a 9-month history of generalized weakness, severest in his shoulders and neck muscles, associated with ptosis, and difficulty in chewing and swallowing. All symptoms progressively worsened and partially subsided with rest. Four months earlier, pain and redness of his nose and right ear had occurred for 1 week, and cleared...References1. RosenowHurley EB. Disorders of the thymus: a review. Arch Intern Med. 1984;144:763-70. CrossrefMedlineGoogle Scholar2. Osserman K. Myasthenia Gravis. New York: Grune & Stratton, Inc.; 1958. Google Scholar3. ArkinMasi CA. Relapsing polychondritis: review of current status and case report. Semin Arthritis Rheum. 1975;5:41-62. CrossrefMedlineGoogle Scholar4. McAdamO'HanlanBluestonePearson LMRC. Relapsing polychondritis: prospective study of 23 patients and a review of the literature. Medicine (Baltimore). 1976;55:193-215. CrossrefMedlineGoogle Scholar5. MichetMcKennaLuthraO'Fallon CCHW. Relapsing polychondritis: survival and predictive role of early disease manifestations. Ann Intern Med. 1986;104:74-8. LinkGoogle Scholar6. EbringerRookSwanaBottazzoDoniach RGGGD. Autoantibodies to cartilage and type II collagen in relapsing polychondritis and other rheumatic diseases. Ann Rheum Dis. 1981;40:473-9. CrossrefMedlineGoogle Scholar7. RajapakseBywaters DE. Cell-mediated immunity to cartilage proteoglycan in relapsing polychondritis. Clin Exp Immunol. 1974;16:497-502. MedlineGoogle Scholar8. BieseckerKoffler GD. Immunology of myasthenia gravis. Hum Pathol. 1983;14:419-23. CrossrefMedlineGoogle Scholar9. GoulonEstournetTulliez MBM. Myasthenia gravis and associated diseases. Int J Neurol. 1980;14(1):61-72. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the Veterans Administration Medical Center, East Orange, New Jersey; and the University of Medicine and Dentistry of New Jersey, Newark, New Jersey. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA systematic review of paraneoplastic syndromes associated with thymoma: Treatment modalities, recurrence, and outcomes in resected casesRelapsing PolychondritisUnusual association of seronegative, nonparaneoplastic limbic encephalitis and relapsing polychondritis in a patient with history of thymectomy for myasthenia: a case studyDisorders of Connective TissueGranuloma annulare, relapsing polychondritis, sarcoidosis, and systemic lupus erythematosus: conditions whose dermatologic manifestations may occur as hematologic malignancy-associated mucocutaneous paraneoplastic syndromesSweet's syndrome and relapsing polychondritis: Is their appearance in the same patient a coincidental occurrence or a bona fide association of these conditions?Relapsing polychondritis: A clinical reviewColchicine and indomethacin for the treatment of relapsing polychondritisEntzündliche Erkrankungen des KnorpelsImmune Disorders with Ocular Involvement 15 July 1988Volume 109, Issue 2Page: 163-164KeywordsDentistryHematology and oncologyMedical servicesMusclesMyasthenia gravisNeurologyPtosisShouldersSwallowingThymoma Issue Published: 15 July 1988 PDF DownloadLoading ...