tbuckley/cabot-search huggingface dataset:
BLUE SKY HEALTH PROPAGANDA
Authors: FREDERICK D. STRICKER
Journal: JAMA (1923)

It is a peculiar pleasure to me to discuss with those who are deeply interested in the preservation and prolongation of human life one particular problem of public health work that is of paramount importance. Every physician has undoubtedly considered the many and diverse methods that are generally used to interest the individual in his own welfare, and has wondered, like all investigators in the methods of health education, just how much of this propaganda is really efficient and something that will prove of permanent benefit to mankind. There is a general demand for reliable health information, and the good citizens of this country are looking to the American Medical Association to give them all that science affords for the promotion of personal health and the prevention of disease. It is the essential function of this section to make every member of the association an active advocate of preventive medicine.
Tamoxifen citrate loaded amphiphilic β-cyclodextrin nanoparticles: In vitro characterization and cytotoxicity
Authors: Erem Memisoglu-Bilensoy, Imran Vural, Amélie Bochot, Jack Michel Renoir, Dominique Duchene, A. Atilla Hıncal
Journal: Journal of Controlled Release (2005)
Activity of platelet‐activating factor acetylhydrolase exists in red cell membrane
Authors: Hidemi Yoshida, Kei Satoh, Tada‐Atsu Imaizumi
Journal: American Journal of Hematology (1992)

We have described the intracellular type of platelet-activating factor acetylhydrolase (PAF-AH) in the membrane extract of human red blood cells (RBCs). The enzymatic activity was inhibited by diisopropylfluorophosphate, trypsin or pronase E, but not affected by EDTA or the addition of 1-O-hexadecyl-2-hexadecanoyl-rac-glycero-3-phosphocholine or 1-O-hexadecyl-2-[(cis)-9-octadecenoyl]-rac-glycero-3-phosphocholin e. The activity in 10 healthy volunteers was 3.89 +/- 3.26 pmol/10(9) RBCs/min (or 148 +/- 73 nmol/g protein/min) (mean +/- SD). Since PAF-AH is also known to hydrolyze oxidized derivatives of phosphatidylcholine and since RBCs are not effector cells of PAF, the observed activity in RBC membranes may play a potential role in degrading oxidation products of membrane phospholipids.
Accumulation of radioiodinated 15-(p-iodophenyl)-6-tellurapentadecanoic acid in ischemic myocardium during acute coronary occlusion and reperfusion
Authors: Jesus A. Bianco, Linda A. Pape, Joseph S. Alpert, Miaorong Zheng, Donald Hnatowich, Mark M. Goodman, Furn F. Knapp
Journal: Journal of the American College of Cardiology (1984)
Recombinant activated factor VII (rFVIIa) as a hemostatic agent in liver disease: A break from convention in need of controlled trials
Authors: Stephen H. Caldwell, Charissa Chang, Gail B. Macik
Journal: Hepatology (2004)

The management of coagulopathy in patients with acute and chronic liver disease has undergone little change in many years despite advances in our understanding of the pathogenesis of this problem. In general, deficiency of clotting factors as a result of poor hepatic synthetic function accounts for most of the coagulopathy. However, other processes such as disseminated intravascular coagulation (DIC), hyperfibrinolysis, dysfibrinogenemia, hemolysis, and a decrease in number or function of platelets may be present and thus add to the complexity of the problem. Coexisting portal hypertension and the associated risks of volume expansion, renal failure, and endothelial dysfunction add even more difficulty to the management of these patients. The clinician's despair is only exacerbated by uncertainty regarding the significance of laboratory indices of coagulation and the lack of agreement between health care providers regarding how to use these indices. Simple, conventional interventions such as vitamin K or plasma administration often produce only limited amelioration, and the latter carries the potential disadvantage of volume overexpansion as well as the risk of infection and transfusion reactions. Into this complex and uncertain clinical situation has arrived the antihemophilic agent recombinant activated factor VII (rFVIIa). Its development has led to a fundamental re-evaluation of the classic understanding of the normal clotting cascade. Moreover, use of this product in liver disease patients is increasing despite the lack of definitive studies or literature to guide therapy. Herein we review the mechanism of action of this agent, report the clinical applications in patients with liver disease, address the limitations and risks associated with the drug, and discuss the issue of its cost-effectiveness.
A 26-Year-Old Woman With Shoulder Pain, 1 Year Later
Authors: Richard A. Parker
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Health Care Reform and Reduced Racial Disparities in Minimally Invasive Surgery
Authors: Andrew P. Loehrer, Zirui Song, Hugh G. Auchincloss, Matthew M. Hutter
Journal: JAMA Surgery (2013)

<h3>Importance</h3> Racial disparities in receipt of minimally invasive surgery (MIS) persist in the United States and have been shown to also be associated with a number of driving factors, including insurance status. However, little is known as to how expanding insurance coverage across a population influences disparities in surgical care. <h3>Objective</h3> To evaluate the impact of Massachusetts health care reform on racial disparities in MIS. <h3>Design, Setting, and Participants</h3> A retrospective cohort study assessed the probability of undergoing MIS vs an open operation for nonwhite patients in Massachusetts compared with 6 control states. All discharges (n = 167 560) of nonelderly white, black, or Latino patients with government insurance (Medicaid or Commonwealth Care insurance) or no insurance who underwent a procedure for acute appendicitis or acute cholecystitis at inpatient hospitals between January 1, 2001, and December 31, 2009, were assessed. Data are from the Hospital Cost and Utilization Project State Inpatient Databases. <h3>Intervention</h3> The 2006 Massachusetts health care reform, which expanded insurance coverage for government-subsidized, self-pay, and uninsured individuals in Massachusetts. <h3>Main Outcomes and Measures</h3> Adjusted probability of undergoing MIS and difference-in-difference estimates. <h3>Results</h3> Prior to the 2006 reform, Massachusetts nonwhite patients had a 5.21–percentage point lower probability of MIS relative to white patients (<i>P</i> &lt; .001). Nonwhite patients in control states had a 1.39–percentage point lower probability of MIS (<i>P</i> = .007). After reform, nonwhite patients in Massachusetts had a 3.71–percentage point increase in the probability of MIS relative to concurrent trends in control states (<i>P</i> = .01). After 2006, measured racial disparities in MIS resolved in Massachusetts, with nonwhite patients having equal probability of MIS relative to white patients (0.06 percentage point greater;<i>P</i> = .96). However, nonwhite patients in control states without health care reform have a persistently lower probability of MIS relative to white patients (3.19 percentage points lower;<i>P</i> &lt; .001). <h3>Conclusions and Relevance</h3> The 2006 Massachusetts insurance expansion was associated with an increased probability of nonwhite patients undergoing MIS and resolution of measured racial disparities in MIS.
Modifiers of timing and possible triggers of acute myocardial infarction in the thrombolysis in myocardial infarction phase II (TIMI II) study group
Authors: Geoffrey H. Tofler, James E. Muller, Peter H. Stone, Sandra Forman, Rachel E. Solomon, Genell L. Knatterud, Eugene Braunwald
Journal: Journal of the American College of Cardiology (1992)
The Effect of Sublingual Nitroglycerin Upon Left Ventricular Myocardial Function.
Authors: Joseph W. Linhart
Journal: Annals of Internal Medicine (1969)

s1 May 1969The Effect of Sublingual Nitroglycerin Upon Left Ventricular Myocardial Function.Joseph W. Linhart, M.D., Frank J. Hildner, M.D., S. Serge Barold, M.D., Philip Samet, M.D.Joseph W. Linhart, M.D.Search for more papers by this author, Frank J. Hildner, M.D.Search for more papers by this author, S. Serge Barold, M.D.Search for more papers by this author, Philip Samet, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1079_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough recent investigations have elucidated most of the mechanisms of action of nitroglycerine, its effect upon left ventricular myocardial function is still not clear. Therefore, left ventricular function was determined during left heart catheterization before and after 0.4 to 0.6 mg nitroglycerin, sublingually, in 23 patients (18 men and 5 women) ranging in age from 41 to 68 years (mean, 54). Left ventricular function curves, relating stroke work to end-diastolic pressure, were constructed using a graded infusion of angiotensin to augment afterload. Sixteen of the 23 patients were shown to have significant coronary artery disease by cineangiography.Nitroglycerin produced a... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Antonio, Texas; and Miami Beach, Florida PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1079-1079KeywordsCatheterizationHeartStable coronary artery diseaseStroke Issue Published: 1 May 1969 PDF downloadLoading ...
Medical Informatics
Authors: William R. Hersh
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SIGNIFICANCE OF IMIDAPRIL IN THE DIRECT INHIBITION OF MATRIX METALLOPROTEINASES IN EXPEIMENTAL ABDOMINAL AORTIC ANEURYSM; COMPARISON WITH LOSARTAN
Authors: Toru Miyoshi, Kazufumi Nakamura, Hiroshi Morita, Kengo Kusano, Hiroshi Ito
Journal: Journal of the American College of Cardiology (2012)
Human immunodeficiency virus (HIV) nef-specific cytotoxic T lymphocytes in noninfected heterosexual contact of HIV-infected patients.
Authors: P Langlade-Demoyen, N Ngo-Giang-Huong, F Ferchal, E Oksenhendler
Journal: Journal of Clinical Investigation (1994)

We report on the detection of HIV-specific cytotoxic T lym- phocytes (CTL) among 23 regular partners of HIV-infected individuals.15 of the 46 individuals enrolled in the study were positive for HLA-A2.1 typing.Among the 23 contacts studied, 7 were seropositive and 16 were seronegative on repeated tests.None of the 16 seronegative contacts were positive for p24 anti- genemia nor were they positive by the lymphocytes coculture assay, although, in two instances HIV-1 DNA could be de- tected by PCR (in one case using agag SK 38/39 primer, and in the other using a primer for the pol P3/P4 primer).These two individuals remained seronegative for 18 and 36 mo, respec- tively.HIV-specific cytotoxicity was performed in the 15 HLA-A2.1 subjects (7 indexes, 2 seropositive contacts, and 6 seronegative contacts) and in 4 HLA-matched HIV negative donors.CTL specific for env, gag, or nef proteins could not be detected in unstimulated bulk cultures of peripheral blood lym- phocytes in any of the six seronegative contacts.However, us- ing a limiting dilution assay we found an usually high frequency of HIV nef-specific CTL in six seronegative contacts studied.The frequency of CTL precursors (C1TLp) for HIV env and gag was very similar to that observed in seronegative HLA- matched healthy donors.Because no presence of HIV could be demonstrated in these individuals, these findings argue against the possibility of a silent HIV infection and suggest that a CTL response against nef may be involved in a rapid and effective clearance of the virus after sexual exposure.(
Diet and cancer
Authors: A. R P Walker
Journal: BMJ (1994)

EDITOR,—In her review of diet and cancer Joan Austoker lists several dietary factors that may protect against cancer, but she does not mention the possible role of lower energy intake.1 At a meeting of the US President's Commission on Breast Cancer, summarised by Hunter and Trichopoulos,2 studies on rodents were described that indicated that “energy (calorie) restriction of as little as 10% … had a steeper and …
Voluntary euthanasia commands majority support
Authors: J. Oliver
Journal: BMJ (1995)

did it?"and "How do we stop it?"may be of little relevance after an earthquake, they are uppermost in the mind of anyone subject to continual bom- bardment and ethnic cleansing.Failure to engage with these issues can increase a sense of victimhood and disempowerment; and attempts to remain politically neutral in the face of genocide may well be construed as tacit collaboration with the aggessor and make effective therapeutic work impossible.Human identity rests on the network of social relations that we build around ourselves: the tie of family, work, and community, and the emotional bond we make with our physical environment.One might argue that the main psychic injury of war is the disruption of those ties, the destruction of identity through the destruction of our social world.Thus any thorough evaluation of psycho- logical treatments for traumatic stress should compare their effectiveness with the impact on mental health of non-psychological interventions such as community redevelopment projects.Only then can scarce resources be allocated in the most appropriate way.
Adrenal hypoplasia congenita with hypogonadotropic hypogonadism: evidence that DAX-1 mutations lead to combined hypothalmic and pituitary defects in gonadotropin production.
Authors: R L Habiby, P Boepple, L Nachtigall, P M Sluss, W F Crowley, J L Jameson
Journal: Journal of Clinical Investigation (1996)

Adrenal hypoplasia congenita (AHC) is an X-linked disorder that typically presents with adrenal insufficiency during infancy. Hypogonadotropic hypogonadism (HHG) has been identified as a component of this disorder in affected individuals who survive into childhood. Recently, AHC was shown to be caused by mutations in DAX-1, a protein that is structurally similar in its carboxyterminal region to orphan nuclear receptors. We studied two kindreds with clinical features of AHC and HHG. DAX-1 mutations were identified in both families. In the JW kindred, a single base deletion at nucleotide 1219 was accompanied by an additional base substitution that resulted in a frameshift mutation at codon 329 followed by premature termination. In the MH kindred, a GGAT duplication at codon 418 caused a frameshift that also resulted in truncation of DAX-1. Baseline luteinizing hormone (LIT), follicle-stimulating hormone (FSH), and free-alpha-subunit (FAS) levels were determined during 24 h of frequent (q10 min) venous sampling. In patient MH, baseline LH levels were low, but FAS levels were within the normal range. In contrast, in patient JW, the mean LH and FSH were within the normal range during baseline sampling, but LH secretion was erratic rather than showing typical pulses. FAS was apulsatile for much of the day, but a surge was seen over a 3-4-h period. Pulsatile gonadotropin releasing hormone (GnRH) (25 ng/kg) was administered every 2 h for 7 d to assess pituitary responsiveness to exogenous GnRH. MH did not exhibit a gonadotropin response to pulsatile GnRH. JW exhibited a normal response to the first pulse of GnRH, but there was no increase in FAS. In contrast to the priming effect of GnRH in GnRH-deficient patients with Kallmann syndrome, GnRH pulses caused minimal secretory responses of LH and no FAS responses in patient JW. The initial LH response in patient JW implies a deficiency in hypothalamic GnRH. On the other hand, the failure to respond to pulsatile GnRH is consistent with a pituitary defect in gonadotropin production. These two cases exemplify the phenotypic heterogeneity of AHC/HHG, and suggest that DAX-1 mutations impair gonadotropin production by acting at both the hypothalamic and pituitary levels.
The homing of bone marrow MSCs to non-osseous sites for ectopic bone formation induced by osteoinductive calcium phosphate
Authors: Guodong Song, Pamela Habibovic, Chongyun Bao, Jing Hu, Clemens A. van Blitterswijk, Huipin Yuan, Wenchuan Chen, Hockin H.K. Xu
Journal: Biomaterials (2013)
The Massachusetts General Hospital (MGH) Hairpulling Scale: 1. Development and Factor Analyses
Authors: Nancy J. Keuthen, Richard L. O’Sullivan, Joseph N. Ricciardi, David Shera, Cary R. Savage, Andrea S. Borgmann, Michael A. Jenike, Lee Baer
Journal: Psychotherapy and Psychosomatics (1995)

We developed the MGH Hairpulling Scale to provide a brief, self-report instrument for assessing repetitive hairpulling. Seven individual items, rated for severity from 0 to 4, assess urges to pull, actual pulling, perceived control, and associated distress. We administered the scale to 119 consecutive patients with chronic hairpulling. Statistical analyses indicate that the seven items form a homogenous scale for the measurement of severity in this disorder.
Accuracy of Magnetic Resonance Cholangiopancreatography for Locating Hepatolithiasis and Detecting Accompanying Biliary Strictures
Authors: D. H. Park, M. H. Kim, S. S. Lee, S. K. Lee, K. P. Kim, J. M. Han, S. Y. Kim, M. H. Song, D. W. Seo, A. Y. Kim, T. K. Kim, Y. I. Min
Journal: Endoscopy (2004)

Magnetic resonance cholangiopancreatography (MRCP) is rapidly replacing diagnostic endoscopic retrograde cholangiopancreatography (ERCP) in various pancreaticobiliary diseases. This study was designed to evaluate the accuracy of MRCP in detection of hepatolithiasis and accompanying biliary strictures.A prospective study over 2 years was conducted in 66 patients with primary intrahepatic stones. All patients with hepatolithiasis underwent percutaneous transhepatic cholangioscopy (PTC) within 2 weeks of the MRCP examination. The MRCP findings were compared with those of PTC as the reference standard for assessing the location of intrahepatic stones and the presence or absence of accompanying biliary strictures.The sensitivity, specificity, and accuracy of MRCP for detecting and locating intrahepatic stones were 97 %, 99 %, and 98 %, respectively. The sensitivity, specificity, and accuracy of MRCP for detecting and locating intrahepatic bile duct strictures were 93 %, 97 %, and 97 %, respectively. During PTC, six of the 66 patients (9 %) were found on histology to have intraductal cholangiocarcinoma in stone-bearing ducts, which had not been suspected on MRCP.In this study, MRCP allowed intrahepatic stones and accompanying biliary strictures to be located accurately. MRCP may therefore be able to replace diagnostic ERCP in patients with primary intrahepatic stones. However, MRCP had a limited ability to reveal concurrent intraductal cholangiocarcinoma associated with hepatolithiasis.
Aminophylline fails to improve the outcome of cardiopulmonary resuscitation from prolonged ventricular fibrillation: A placebo-controlled, randomized, blinded experimental study
Authors: Laszlo Littmann, Peter T. Ashline, William J. Hayes, Pal Kempler, Richard M. Raymond, H.James Norton, Robert H. Svenson, Jan R. Tuntelder, George P. Tatsis
Journal: Journal of the American College of Cardiology (1994)
Alcohol: Use and Abuse in America
Authors: Roland E. Herrington
Journal: JAMA (1986)

Occasionally, a book comes along that says almost everything that needs to be said concerning some aspect of the alcohol problem in America. This is the first book I have seen that explicates all aspects in an authoritative and interesting way. Jack Mendelson and Nancy Mello have contributed enormously to the scientific literature over the last two decades. Now, they have broadened their sights to address the leading social problems inherent in alcohol use in our country. The book also includes a concise update of current knowledge in the biologic and behavioral areas. The book is divided into three major sections. The first section is entitled "Alcohol Use in Perspective." It describes use and abuse of alcohol from the earliest civilizations through colonial times and the Western frontier up to our current situation. Insightful for today is the depiction of the role alcohol played in the Old West, with respect
SCINTIGRAPHIC AND HEMODYNAMIC EVALUATION OF CARDIAC FUNCTION IMMEDIATELY AFTER VALVE REPLACEMENT
Authors: R. J. Gray, T. M. Bateman, D. Sethna, A. Chaux, J. Maddahi, C. M. Conklin, J. M. Matloff, D. S. Berman
Journal: Clinical Nuclear Medicine (1982)

Gray, R. J.; Bateman, T. M.; Sethna, D.; Chaux, A.; Maddahi, J.; Conklin, C. M.; Matloff, J. M.; Berman, D. S. Author Information