tbuckley/cabot-search huggingface dataset:
Sweet's syndrome: a spectrum of unusual clinical presentations and associations
Authors: C.Y. Neoh, A.W.H. Tan, S.K. Ng
Journal: British Journal of Dermatology (2007)

Journal Article Sweet's syndrome: a spectrum of unusual clinical presentations and associations Get access C.Y. Neoh, C.Y. Neoh National Skin Centre, 1 Mandalay Road, Singapore 308205, Singapore Correspondence: Dr C.Y. Neoh. E‐mail: cyneoh@nsc.gov.sg Search for other works by this author on: Oxford Academic Google Scholar A.W.H. Tan, A.W.H. Tan National Skin Centre, 1 Mandalay Road, Singapore 308205, Singapore Search for other works by this author on: Oxford Academic Google Scholar S.K. Ng S.K. Ng National Skin Centre, 1 Mandalay Road, Singapore 308205, Singapore Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue 3, 1 March 2007, Pages 480–485, https://doi.org/10.1111/j.1365-2133.2006.07677.x Published: 01 March 2007
Tuberculosis Treatment in Developing Nations-Reply
Authors: Mario C. Raviglione
Journal: JAMA (1995)

<h3>In Reply.</h3> —We agree with Mr Kocs on the need to broaden our approach to tuberculosis. Kocs condemns the imbalance between disease burden and research that has been best described by the Commission on Health Research for Development: 95% of health research is done in industrialized countries, whereas 93% of the disease burden is in the developing world.<sup>1</sup>This must be addressed by the world health and research community. Kocs rightly points out the need to attune tuberculosis control to local societies and cultures. Of course, far more operational research would help greatly in this regard. However, each year nearly 3 million people die of tuberculosis in the developing world. Since cost-effective techniques for treating tuberculosis in low-income countries are well established and the strategy for their implementation is known, the priority must therefore be intervention, and rapidly. The control strategy adopted by the World Health Organization has been
Rapid Bacterial Whole-Genome Sequencing to Enhance Diagnostic and Public Health Microbiology
Authors: Sandra Reuter, Matthew J. Ellington, Edward J. P. Cartwright, Claudio U. Köser, M. Estée Török, Theodore Gouliouris, Simon R. Harris, Nicholas M. Brown, Matthew T. G. Holden, Mike Quail, Julian Parkhill, Geoffrey P. Smith, Stephen D. Bentley, Sharon J. Peacock
Journal: JAMA Internal Medicine (2013)

<h3>Importance</h3> The latest generation of benchtop DNA sequencing platforms can provide an accurate whole-genome sequence (WGS) for a broad range of bacteria in less than a day. These could be used to more effectively contain the spread of multidrug-resistant pathogens. <h3>Objective</h3> To compare WGS with standard clinical microbiology practice for the investigation of nosocomial outbreaks caused by multidrug-resistant bacteria, the identification of genetic determinants of antimicrobial resistance, and typing of other clinically important pathogens. <h3>Design, Setting, and Participants</h3> A laboratory-based study of hospital inpatients with a range of bacterial infections at Cambridge University Hospitals NHS Foundation Trust, a secondary and tertiary referral center in England, comparing WGS with standard diagnostic microbiology using stored bacterial isolates and clinical information. <h3>Main Outcomes and Measures</h3> Specimens were taken and processed as part of routine clinical care, and cultured isolates stored and referred for additional reference laboratory testing as necessary. Isolates underwent DNA extraction and library preparation prior to sequencing on the Illumina MiSeq platform. Bioinformatic analyses were performed by persons blinded to the clinical, epidemiologic, and antimicrobial susceptibility data. <h3>Results</h3> We investigated 2 putative nosocomial outbreaks, one caused by vancomycin-resistant<i>Enterococcus faecium</i>and the other by carbapenem-resistant<i>Enterobacter cloacae</i>; WGS accurately discriminated between outbreak and nonoutbreak isolates and was superior to conventional typing methods. We compared WGS with standard methods for the identification of the mechanism of carbapenem resistance in a range of gram-negative bacteria (<i>Acinetobacter baumannii, E cloacae, Escherichia coli</i>, and<i>Klebsiella pneumoniae</i>). This demonstrated concordance between phenotypic and genotypic results, and the ability to determine whether resistance was attributable to the presence of carbapenemases or other resistance mechanisms. Whole-genome sequencing was used to recapitulate reference laboratory typing of clinical isolates of<i>Neisseria meningitidis</i>and to provide extended phylogenetic analyses of these. <h3>Conclusions and Relevance</h3> The speed, accuracy, and depth of information provided by WGS platforms to confirm or refute outbreaks in hospitals and the community, and to accurately define transmission of multidrug-resistant and other organisms, represents an important advance.
Use of Ethacrynic Acid in Mannitol-Resistant Oliguric Renal Failure
Authors: Raymond G. Auger
Journal: JAMA (1968)

Two patients had oliguric acute renal failure in which there was no response to intravenously administered mannitol. In both cases, diuresis resulted after simultaneous administration of mannitol and ethacrynic acid intravenously. Dialysis treatment was unnecessary. The production of a greater volume of urine decreases the tendency toward excess total body water and sodium, and extracellular potassium, and simplifies management. A therapeutic trial with both these drugs may be indicated in the oliguric phase of acute renal failure.
Venipuncture and Cardiac Arrest
Authors: P.K. Raghuprasad
Journal: JAMA (1979)

To the Editor.—  I endorse all of the comments of Reuben Tizes, MD, on the subject of cardiac arrest occurring during venipuncture (240:213, 1978), as I had the misfortune of witnessing one myself recently. The patient was one of our own laboratory technicians who had given blood on several occasions as a control in various studies in our department. He insisted that he give the blood lying on a couch, since he is extremely prone to fainting. While drawing blood he said to me that he was  and that I should terminate the phlebotomy. I did not withdraw the needle but stopped drawing on the plunger in the hope that the fainting episode would subside in a few seconds and I would be able to resume the procedure. However, as he looked extremely pale, I felt his pulse and detected extreme bradycardia (approximately 20 beats per minute, although an
The length of hospitalization after acute myocardial infarction determined by risk calculation.
Authors: E B Madsen, P Hougaard, E Gilpin, A Pedersen
Journal: Circulation (1983)

The feasibility of the use of a Cox model for risk assessment of individualized hospital discharge after myocardial infarction was evaluated. First, a previously developed prognostic index computed at the fifth day after admission was tested on a new population of 1140 patients. It was confirmed that after 5 days half of the patients (52%) could be discharged with low risk. Second, a new competing risk variant of the Cox model that updates prognosis according to the occurrence of complications was developed that describes the risk of death, cardiac arrest, and cardiogenic shock within 44 days after hospital admission. With a risk of one of these events being below 2% during a 14 day period after proposed discharge, 453 patients of 966 survivors (47%) could be discharged after only 5 days. A longer stay (of up to 30 days) was proposed for 338 patients (35%) to achieve the same level of risk. The savings in hospitalization days would be 15%. These results were confirmed in a new sample of 197 patients from the same institution who were discharged according to the proposed system. Of the 169 day 5 survivors, 67% were discharged on days 6 through 15 and this resulted in only two unexpected deaths and a 20% savings in hospitalization days. We conclude that individually determined discharge time is feasible without increased risk of death of severe complications after early discharge.
Genetics consortiums can offer views facilitating best practice in Alzheimer's disease
Authors: S. Lovestone
Journal: BMJ (1998)

EDITOR—Alzheimer's disease is often taken as an example of a disorder for which the impact of the new genetics will be met, 1 2 and it was with this in mind that the United Kingdom Alzheimer's Disease Genetics Consortium was formed. Members of the consortium are clinicians involved in both genetics and dementia care, academics, members of lay organisations, and representatives from pharmaceutical research; they meet to consider the consequences of the growing understanding of genetics in Alzheimer's disease. Through …
Successful Endoscopic Resection of an Esophageal Metastasis from a Preceding Squamous-Cell Tonsillar Carcinoma
Authors: C. Jaeger, A. May, L. Gossner, T. Rabenstein, M. Schroeder, M. Stolte, C. Ell
Journal: Endoscopy (2005)

This report describes the case of a 62-year-old man with tonsillar carcinoma who had undergone esophagectomy due to an esophageal metastasis. Subsequently, a second metastasis occurred in the residual esophagus, and he presented for evaluation for local endoscopic therapy. The initial upper endoscopy revealed a type IIa - c lesion at 21 cm from the incisors, within a segment suspicious for Barrett's mucosa. As part of the complex treatment approach in this patient, endoscopic resection of the lesion was carried out using the suck-and-cut technique with ligation. Histology showed that the lesion was a metastasis from a squamous-cell carcinoma, with focal infiltration of the upper submucosal layer and vascular invasion consistent with the hypothesis of hematogenous spread from the preceding tonsillar carcinoma. The resection margins were tumor-free. At the time of writing, the patient had been recurrence-free for more than 9 months. In summary, the present paper describes a unique case of successful endoscopic resection of an esophageal metastasis associated with an antecedent tonsillar carcinoma.
Carcinoma of the Stomach in a Child
Authors: William L. Dixon
Journal: JAMA (1976)

THERE are few well-documented cases of adenocarcinoma of the stomach in children less than 16 years of age. We recently treated an 11-year-old girl who had cancer of the gastric pylorus that mimicked a benign pyloric-channel ulcer. She is the subject of the following case report. <h3>Report of a Case</h3> An 11-year-old Korean-American child was well until September 1972 when she had a two-week history of vomiting, abdominal pain, and dark stools. She also complained of weakness and general malaise. The child was pale, thin, and tired. Her abdomen was flat without palpable masses, but there was slight tenderness to deep palpation in the epigastrium. Results of the rest of the examination were normal. The hemoglobin level was 5 gm/100 ml. The stools reacted strongly for occult blood. The total bilirubin level was 3 mg/100 ml, and the alkaline phosphatase level was mildly elevated. An upper gastrointestinal roentgenographic series disclosed
Birt-Hogg-Dubé Syndrome in an African Patient and a Novel Mutation in the<i>FLCN</i>Gene
Authors: Ellen N. Pritchett, Jeanyoung Kim, Khyati Patel, Tejesh Patel, Carrie Ann Cusack
Journal: JAMA Dermatology (2014)

Birt-Hogg-Dubé syndrome (BHDS), an autosomal dominant condition caused by mutations in the FLCN gene, is characterized by fibrofolliculomas, spontaneous pneumothorax, and renal cell carcinoma. Herein, we report the first case to our knowledge of BHDS in an African patient.
Segmental analysis of coronary artery lesions using 3-dimensional echocardiography in comparison with coronary angiography: a clinical semiquantitative study
Authors: J. Yao, P.J. de Feijter, J.D. Kasprzak, M.A. Taama, J.R.T.C. Roolandt
Journal: Journal of the American College of Cardiology (1998)
Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis
Authors: Samar H. Ibrahim, Yuko Akazawa, Sophie C. Cazanave, Steven F. Bronk, Nafisa A. Elmi, Nathan W. Werneburg, Daniel D. Billadeau, Gregory J. Gores
Journal: Journal of Hepatology (2010)
CLIMATIC VERSUS SERUM TREATMENT OF PULMONARY TUBERCULOSIS.
Authors: F. E. WAXHAM
Journal: JAMA (1898)

The climatic treatment of disease is a most important subject, and one that I am convinced has not been fully studied and appreciated. No doubt many failures are to be attributed to the fact that neither proper cases nor proper climate have been selected. Because a patient has tuberculosis is no reason or excuse why he should be sent two thousand miles or more from home and comfort and friends, only to find, perhaps, his malady increased, and to die among strangers. We should prescribe a change of climate with as much discretion and judgment as any other remedy. Whether a patient should be sent from come in search of health will depend upon several conditions. The stage of the disease, the vigor, vitality, disposition of the patient, and the means with which to live comfortably, are all to be considered. Physicians in the Rocky Mountain region are continually meeting
The Philadelphia Epidemic of Legionnaire's Disease: Clinical, Pulmonary, and Serologic Findings Two Years Later
Authors: GARY L. LATTIMER
Journal: Annals of Internal Medicine (1979)

Clinical, pulmonary, and serologic findings in Legionnaires who attended the 1976 American Legion Convention in Philadelphia were studied 2 years after the Legionnaires' disease epidemic there. All 31 survivors of Legionnaires' disease studied became ill within 2 weeks after the convention, and 18 had not fully recovered 2 years after the epidemic. Twenty-five (28%) of 90 additional Legionnaires exposed at the convention but not diagnosed as having Legionnaires' disease became ill during the same time interval; five of these had symptoms during the next 2 years. Survivors had decreased diffusion capacities measured by the carbon monoxide single-breath method. These differences could not be accounted for by ventilation abnormalities or concurrent illness. Significant levels of IgG or IgM antibodies persisted in 94% of survivors of Legionnaires' disease and in 53% of Legionnaires exposed at the convention, which suggests a high prevalence of subclinical infection. Persistence of IgM antibody raises the question of latency or subclinical infection as part of the natural history of Legionnaires' disease.
Attenuation of NMDA Receptor Activity and Neurotoxicity by Nitroxyl Anion, NO−
Authors: Won-Ki Kim, Yun-Beom Choi, Posina V. Rayudu, Prajnan Das, Wael Asaad, Derrick R. Arnelle, Jonathan S. Stamler, Stuart A. Lipton
Journal: Neuron (1999)
Ambient Air Pollution and Lipoprotein-Associated Phospholipase A <sub>2</sub> in Survivors of Myocardial Infarction
Authors: Irene Brüske, Regina Hampel, Zita Baumgärtner, Regina Rückerl, Sonja Greven, Wolfgang Koenig, Annette Peters, Alexandra Schneider
Journal: Environmental Health Perspectives (2011)

Increasing evidence suggests a proatherogenic role for lipoprotein-associated phospholipase A₂ (Lp-PLA2). A meta-analysis of published cohorts has shown that Lp-PLA2 is an independent predictor of coronary heart disease events and stroke.In this study, we investigated whether the association between air pollution and cardiovascular disease might be partly explained by increased Lp-PLA2 mass in response to exposure.A prospective longitudinal study of 200 patients who had had a myocardial infarction was performed in Augsburg, Germany. Up to six repeated clinical examinations were scheduled every 4-6 weeks between May 2003 and March 2004. Supplementary to the multicenter AIRGENE protocol, we assessed repeated plasma Lp-PLA2 concentrations. Air pollution data from a fixed monitoring site representing urban background concentrations were collected. We measured hourly means of particle mass [particulate matter (PM) < 10 µm (PM₁₀) and PM < 2.5 µm (PM(2.5)) in aerodynamic diameter] and particle number concentrations (PNCs), as well as the gaseous air pollutants carbon monoxide (CO), sulfur dioxide (SO₂), ozone (O₃), nitric oxide (NO), and nitrogen dioxide (NO₂). Data were analyzed using mixed models with random patient effects.Lp-PLA2 showed a positive association with PM₁₀, PM(2.5), and PNCs, as well as with CO, NO₂, NO, and SO₂ 4-5 days before blood withdrawal (lag 4-5). A positive association with O₃ was much more immediate (lag 0). However, inverse associations with some pollutants were evident at shorter time lags.These preliminary findings should be replicated in other study populations because they suggest that the accumulation of acute and subacute effects or the chronic exposure to ambient particulate and gaseous air pollution may result in the promotion of atherosclerosis, mediated, at least in part, by increased levels of Lp-PLA2.
Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population
Authors: Sumithira Vasu, Susan F. Leitman, John F. Tisdale, Matthew M. Hsieh, Richard W. Childs, A. John Barrett, Daniel H. Fowler, Michael R. Bishop, Elizabeth M. Kang, Harry L. Malech, Cynthia E. Dunbar, Hanh M. Khuu, Robert Wesley, Yu Y. Yau, Charles D. Bolan
Journal: Blood (2008)
YIELD OF SOMATOSTATIN RECEPTOR SCINTIGRAPHY (SRS) IN MEDULLARY THYROID CARCINOMA (MTC); IN RELATION TO CALCITONIN LEVEL
Authors: E. S. Delpassand, P. Bassa, W. Broussard, E. Razmpa, T. P. Haynie, D. A. Podoloff
Journal: Clinical Nuclear Medicine (1996)

Delpassand, E.; Bassa, P.; Broussard, W.; Razmpa, E.; Haynie, T.; Podoloff, D. Author Information
PTU-193 Gastro-oesophageal reflux (GORD) and coeliac disease: a bidirectional study
Authors: K Evans, S M Barrett, A Smythe, D S Sanders
Journal: Gut (2012)

<h3>Introduction</h3> There are limited data assessing the relationship between coeliac disease and GORD. We aimed to establish the prevalence and nature of GORD symptoms in patients with coeliac disease, and the prevalence of undetected coeliac disease in those presenting to endoscopy with GORD symptoms. <h3>Methods</h3> Group A were histologically proven patients with coeliac disease (n=225) who were asked to complete a validated reflux questionnaire and then compared to age/sex-matched controls (n=348). Group B were consecutive GORD patients undergoing endoscopy who had duodenal biopsies and coeliac serology taken. (n=851) Furthermore, patients with newly diagnosed coeliac disease underwent manometry and pH studies prior to commencing gluten free diet (n=33). <h3>Results</h3> In Group A the prevalence of GORD was greater in coeliac disease (66%) than in healthy controls (50%) p=0.0001. Coeliac patients also report reflux of greater severity: coeliac disease OR=6.8, 95% CI=3.6 to 12.7, p≤0.001. In Group B at endoscopy the prevalence of undetected coeliac disease was 1.66% (14/851). In Group C 31/33 were able to tolerate manometry and complete testing (2 had partial investigation before the catheter was removed) At manometry 30/33 (91%) had a normal lower oesophageal sphincter (LOS). 2/33 had a hypotensive LOS. 21/33 (64%) had normal oesophageal motility. However, 10/33 had a hypocontractile oesophagus, 1 was hypertensive and 1 showed functional oesophagogastric junction obstruction. During manometry 6/31 (19%) demonstrated significant reflux, 6/31 (19%) had some reflux and the final 19/31 (61%) had no reflux episodes. In these coeliac patients neither the presence of symptoms nor abnormal oesophageal study findings was related to histological grade of coeliac disease, (villous atrophy) or serology findings. <h3>Conclusion</h3> Up to two thirds of patients with coeliac disease report reflux symptoms and one third have demonstrable abnormalities of oesophageal motility and reflux. However, in an unselected population at endoscopy, reflux symptoms are not predictive of coeliac disease. <h3>Competing interests</h3> None declared.
Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4
Authors: Yuzhen Wang, Taoyong Chen, Chaofeng Han, Donghua He, Haibo Liu, Huazhang An, Zhen Cai, Xuetao Cao
Journal: Blood (2007)
Phosphorylated Caveolin-1 Regulates Rho/ROCK-Dependent Focal Adhesion Dynamics and Tumor Cell Migration and Invasion
Authors: Bharat Joshi, Scott S. Strugnell, Jacky G. Goetz, Liliana D. Kojic, Michael E. Cox, Obi L. Griffith, Simon K. Chan, Steven J. Jones, Sher-Ping Leung, Hamid Masoudi, Samuel Leung, Sam M. Wiseman, Ivan R. Nabi
Journal: Cancer Research (2008)

Rho/ROCK signaling and caveolin-1 (Cav1) are implicated in tumor cell migration and metastasis; however, the underlying molecular mechanisms remain poorly defined. Cav1 was found here to be an independent predictor of decreased survival in breast and rectal cancer and significantly associated with the presence of distant metastasis for colon cancer patients. Rho/ROCK signaling promotes tumor cell migration by regulating focal adhesion (FA) dynamics through tyrosine (Y14) phosphorylation of Cav1. Phosphorylated Cav1 is localized to protrusive domains of tumor cells and Cav1 tyrosine phosphorylation is dependent on Src kinase and Rho/ROCK signaling. Increased levels of phosphorylated Cav1 were associated with elevated GTP-RhoA levels in metastatic tumor cells of various tissue origins. Stable expression and knockdown studies of Cav1 in tumor cells showed that phosphorylated Cav1 expression stimulates Rho activation, stabilizes FAK association with FAs, and promotes cell migration and invasion in a ROCK-dependent and Src-dependent manner. Tyrosine-phosphorylated Cav1, therefore, functions as an effector of Rho/ROCK signaling in the regulation of FA turnover and, thereby, tumor cell migration and invasion. These studies define a feedback loop between Rho/ROCK, Src, and phosphorylated Cav1 in tumor cell protrusions, identifying a novel function for Cav1 in tumor metastasis that may contribute to the poor prognosis of some Cav1-expressing tumors.
Peter Thomas John Christopher Plumbly Warner
Authors: Iona Warner
Journal: BMJ (2007)

> Do not grieve for me I have lived a happy life 
> 
> Thanks to those that shared 
> 
> With me along the way 
> 
> I know I failed to show 
> 
> Due appreciation 
> 
> Forgive me. 
> 
> And thanks to Iona 
> 
> My beloved wife 
> 
> Who took the rough 
> 
> With the smooth 
> 
> With a smile 
> 
> Peter 

Peter Thomas John Christopher Plumbly Warner, beloved husband of Iona (nee Henderson), passed away at his residence on 9 January 2006. 

He is survived by his wife, Iona, and by his children, Susanna of Calgary; Ianthe of Winnipeg; Willy (Abby) of Idaho, USA; Sarah (Tom Kobar) of The Pas; Charlotte of Winnipeg; and Oenone …