Corticoid Therapy for Pretibial Myxedema
Authors: FREDERICK L. BENOIT
Journal: Annals of Internal Medicine (1967)

Article1 April 1967Corticoid Therapy for Pretibial MyxedemaObservations on the Long-acting Thyroid StimulatorFREDERICK L. BENOIT, FRANCIS S. GREENSPAN, M.D., F.A.C.P.FREDERICK L. BENOITSearch for more papers by this author, FRANCIS S. GREENSPAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-4-711 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTreatment of pretibial myxedema, the enigmatic skin lesion associated with hyperthyroidism, has been only sporadically successful, despite the utilization of various therapeutic modalities. Corticoids, one group of medications used, have given widely variable results. In the first report mentioning steroid therapy systemic cortisone was given to counteract the activity of locally injected hyaluronidase, and it was noted that the pretibial lesions disappeared completely (1). Although some subsequent reports confirmed this observation (2-5), many others recorded no improvement after giving systemic steroids in a wide range of dosages (6-15). Similarly, the effect of their local application to the lesion, either by...References1. EPSTEINDAVISWEINSTEIN EAES: Localized myxedema. Arch. Derm. (Chicago) 64: 227, 1951. Google Scholar2. KIRKEBY K: Cortisone and ACTH in the treatment of localized myxedema. J. Clin. Endocr. 14: 561, 1954. CrossrefGoogle Scholar3. HADIDABOULARDHADIDA ECJ: Myxoedème circonscrit prétibial. Bull. Soc. Franc. Derm. Syph. 64: 397, 1957. Google Scholar4. KRISSPLESHAKOVCHIEN JPVJR: Isolation and identification of the long-acting thyroid stimulator and its relation to hyperthyroidism and circumscribed pretibial myxedema. J. Clin. Endocr. 24: 1005, 1964. CrossrefMedlineGoogle Scholar5. SNYDERGREENSOLOMON NJDEDH: Glucocorticoid-induced disappearance of long-acting thyroid stimulator in the ophthalmopathy of Graves' disease. Ibid., p. 1129. 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GREENSPAN, M.D., F.A.C.P.Affiliations: Oakland and San Francisco, CaliforniaFrom the Clinical Investigation Center and Medical Service, Naval Hospital, Oakland, and the Department of Medicine and Radioactivity Research Center, University of California School of Medicine, San Francisco, Calif.This study was supported by Contract Nonr-222 (51) (NR105 156) between the Office of Naval Research, Department of the Navy, Washington, D. C., and the University of California School of Medicine, San Francisco, Calif., by grant AM-04818, U. S. Public Health Service, Washington, D. C., and by the Department of Medicine, University of California School of Medicine (Cox Fund), San Francisco, Calif.Requests for reprints should be addressed to Director, Clinical Investigation Center, Naval Hospital, Oakland, Calif. 94627. 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