tbuckley/cabot-search huggingface dataset:
Once Upon a Time, a “Family Doc”
Authors: Edward O. McFalls
Journal: Annals of Internal Medicine (2012)

On Being a Doctor2 October 2012Once Upon a Time, a “Family Doc”Edward O. McFalls, MD, PhDEdward O. McFalls, MD, PhDFrom Veterans Affairs Medical Center, Minneapolis, MN 55417.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-7-201210020-00015 Audio Reading - “Once Upon a Time, a “Family Doc”” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Once Upon a Time, a 'Family Doc'," by E.O. McFalls. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Growing up in a tiny village in upstate New York, I was fortunate to have experienced the real meaning of the expression “Family Doc.” Our community was small enough that nearly everyone knew at least something about everyone else. Doc E. was the sole family practitioner in that community and was available for house calls, office visits, and even hospital rounds for the less fortunate. It just so happened that our “Family Doc” was not only our physician but also a close friend of the family. I felt privileged to experience that narrow distinction between a family friend and a ... Author, Article, and Disclosure InformationAffiliations: From Veterans Affairs Medical Center, Minneapolis, MN 55417.Corresponding Author: Edward O. McFalls, MD, PhD, Cardiology (111C), Veterans Affairs Medical Center, 1 Veterans Drive, Minneapolis, MN 55417; e-mail, [email protected]. PreviousarticleNextarticle Advertisement Audio Reading - “Once Upon a Time, a “Family Doc”” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Once Upon a Time, a 'Family Doc'," by E.O. McFalls. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 2 October 2012Volume 157, Issue 7Page: 527-528KeywordsAmbulancesAtrial fibrillationGamesHand strengthHospital medicineNursesPrimary care physiciansStomachThorax ePublished: 2 October 2012 Issue Published: 2 October 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Walking Speed Is a Useful Marker of Frailty in Older Persons
Authors: Yuichiro Yano, Takashi Inokuchi, Kazuomi Kario
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Intraperitoneal Bleeding Demonstrated by Tc-99m Labeled Red Blood Cell Sclntlgraphy
Authors: SIMONA BEN-HAIM, KARIM REZAI
Journal: Clinical Nuclear Medicine (1992)

Tc-99m RBC scintigraphy is known to be useful for the evaluation of gastrointestinal bleeding. The authors describe a patient with a posttraumatic peritoneal tap in whom Tc-99m RBC imaging showed bleeding into the gastrointestinal wall and into the ascitic fluid.
Diabetic ketoacidosis and ruptured ectopic pregnancy: a fatal combination.
Authors: M J Glynn, D Elliot
Journal: BMJ (1984)

Abdominal pain severe enough to mimic acute abdominal disease is a common symptom of diabetic ketoacidosis and is reported in 13% to 20% of cases.1 2 During undergraduate training the high mortality associated with laparotomy in these severely ill patients is emphasised, but insufficient emphasis is placed on a diagnostic error that may be equally dangerous? namely, the failure to recognise the occasional precipitation of ketoacidosis by genuine abdominal disease.
Social marketing centre launches in England
Authors: Andrew Cole
Journal: BMJ (2006)

The days of simply telling people what is good for them are over, said England's deputy chief medical officer Fiona Adshead at the official launch of the National Social Marketing Centre this week. 

The centre is part of the National Consumer Council, a body that represents the views of consumers but is funded largely by government. It represents a major focus of the health department's new strategy, outlined in its public health white paper Choosing Health , to use marketing techniques and involve the business sector in promoting healthier lifestyles. 

The centre is already closely involved in preparing next year's health promotion campaign on …
404. Roles of Inverted Terminal Repeats (ITRs) and Capsid Proteins from Novel NHP AAVs in rAAV Mediated Gene Transfer
Authors: Xiaoyang Zhou, Guangping Gao, Roland A. Owens, You Lu, Roberto Calcedo, Jim Miller, James M. Wilson
Journal: Molecular Therapy (2005)

Recombinant AAV2 genomes transcapsidated with the capsid from a number of novel primate AAVs including AAV8 and rh.39 have been proven to be more robust gene transfer vehicles than the original AAV2 vector. We have recently isolated and characterized infectious molecular clones of AAV8 and AAVrh.39 and created recombinant AAV vector genomes carrying ITRs from AAV8 and AAVrh.39. Our study on the cleavability of those ITRs by AAV2 Rep in an in vitro nicking assay suggested the possibility of packaging those novel vector genomes with chimeric packaging plasmids consisting of the rep gene from AAV2 and cap genes from other AAVs.
The frowning sign. Multiple forehead furrows in peptic ulcer
Authors: N. P. Trujillo
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Frowning is produced by contraction of the corrugator supercilii muscle. This muscle arises from the lowest point of the frontal bone where it joins the bones of the nose and runs obliquely upwards inserts into the skin under the eyebrows. Its action lowers and brings together the eyebrows so that vertical furrows are formed on the forehead.<sup>1</sup> One of us (T.A.W.) has had the impression that chronic duodenal ulcer patients have an increased number of vertical furrows on the forehead. William Shakespeare may have made the original observation, as quoth by Othello, Act III, scene 3, "I have a pain upon my forehead here." This study was undertaken to test the validity of such an impression. <h3>Material and Methods:—</h3> Two hundred patients from the gastroenterology and general medicine services at the Walter Reed General Hospital and 200 male veterans are included in this study. One hundred
The Tyrosine Phosphatase Shp2 Interacts with NPM-ALK and Regulates Anaplastic Lymphoma Cell Growth and Migration
Authors: Claudia Voena, Chiara Conte, Chiara Ambrogio, Elisabetta Boeri Erba, Francesco Boccalatte, Shabaz Mohammed, Ole N. Jensen, Giorgio Palestro, Giorgio Inghirami, Roberto Chiarle
Journal: Cancer Research (2007)

Abstract Anaplastic large cell lymphomas (ALCL) are mainly characterized by the reciprocal translocation t(2;5)(p23;q35) that involves the anaplastic lymphoma kinase (ALK) gene and generates the fusion protein NPM-ALK with intrinsic tyrosine kinase activity. NPM-ALK triggers several signaling cascades, leading to increased cell growth, resistance to apoptosis, and changes in morphology and migration of transformed cells. To search for new NPM-ALK interacting molecules, we developed a mass spectrometry–based proteomic approach in HEK293 cells expressing an inducible NPM-ALK and identified the tyrosine phosphatase Shp2 as a candidate substrate. We found that NPM-ALK was able to bind Shp2 in coprecipitation experiments and to induce its phosphorylation in the tyrosine residues Y542 and Y580 both in HEK293 cells and ALCL cell lines. In primary lymphomas, antibodies against the phosphorylated tyrosine Y542 of Shp2 mainly stained ALK-positive cells. In ALCL cell lines, Shp2-constitutive phosphorylation was dependent on NPM-ALK, as it significantly decreased after short hairpin RNA (shRNA)–mediated NPM-ALK knock down. In addition, only the constitutively active NPM-ALK, but not the kinase dead NPM-ALKK210R, formed a complex with Shp2, Gab2, and growth factor receptor binding protein 2 (Grb2), where Grb2 bound to the phosphorylated Shp2 through its SH2 domain. Shp2 knock down by specific shRNA decreased the phosphorylation of extracellular signal-regulated kinase 1/2 and of the tyrosine residue Y416 in the activation loop of Src, resulting in impaired ALCL cell proliferation and growth disadvantage. Finally, migration of ALCL cells was reduced by Shp2 shRNA. These findings show a direct involvement of Shp2 in NPM-ALK lymphomagenesis, highlighting its critical role in lymphoma cell proliferation and migration. [Cancer Res 2007;67(9):4278–86]
Effects of communicating individual risks in screening programmes: Cochrane systematic review
Authors: A. Edwards
Journal: BMJ (2003)

<h3>Abstract</h3> <b>Objective</b> To assess the effects of different types of individualised risk communication for patients who are deciding whether to participate in screening. <b>Design</b> Systematic review. <b>Data sources</b> Specialist register of the Cochrane consumers and communication review group, scientific databases, and a manual follow up of references. <b>Selection of studies</b> Studies were randomised controlled trials addressing decisions by patients whether or not to undergo screening and incorporating an intervention with an element of "individualised" risk communication–based on the individual9s own risk factors for a condition (such as age or family history). <b>Outcome measures</b> The principal outcome was uptake of screening tests; further cognitive and affective measures were also assessed to gauge informed decision making. <b>Results</b> 13 studies were included, 10 of which addressed mammography programmes. Individualised risk communication was associated with an increased uptake of screening tests (odds ratio 1.5, 95% confidence interval 1.11 to 2.03). Few cognitive or affective outcomes were reported consistently, so it was not possible to conclude whether this increase in the uptake of tests was related to informed decision making by patients. <b>Conclusions</b> Individualised risk estimates may be effective for purposes of population health, but their effects on increasing uptake of screening programmes may not be interpretable as evidence of informed decision making by patients. Greater attention is required to ways of developing interventions for screening programmes that can achieve this.
In Vivo Evidence of an Endothelin-Induced Vasopressor Tone After Inhibition of Nitric Oxide Synthesis in Rats
Authors: Vincent Richard, Manuela Hogie, Martine Clozel, Bernd-Michael Löffler, Christian Thuillez
Journal: Circulation (1995)

Continuous production of nitric oxide (NO) from endothelial cells permanently inhibits the synthesis and the vasoconstrictor effects of endothelin. Thus, inhibition of NO synthesis might unmask a vasopressor response to endothelin. To assess whether endothelin contributes to the pressor response induced by inhibition of NO synthesis, we tested whether bosentan, a nonpeptide antagonist of ETA and ETB endothelin receptors, affected the hypertensive response induced by the NO synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME).Anesthetized rats received increasing doses of L-NAME (0.1 to 3 mg.kg-1) in the absence or the presence of bosentan (3 mg.kg-1 IV 15 minutes before L-NAME). Bosentan itself did not affect blood pressure. L-NAME induced a dose-dependent increase in mean arterial pressure (percent increase from baseline after 3 mg.kg-1, 25 +/- 5%), and this was reduced by bosentan (13 +/- 3%; P < .05) or by the selective ETA antagonist BQ-123 (3 mg.kg-1: controls, 25 +/- 4%; BQ-123, 14 +/- 5%; P < .01). In contrast, bosentan did not affect the pressor response to phenylephrine (1 to 100 micrograms.kg-1). The response to L-NAME (3 mg.kg-1) was also reduced by bosentan in ganglion-blocked (chlorisondamine 2.5 mg.kg-1: controls, 89 +/- 10%; bosentan, 45 +/- 7%) or pithed rats (controls, 165 +/- 9%; bosentan, 85 +/- 12%; P < .01). Bosentan also inhibited the pressor response to another inhibitor of NO synthesis, NG-nitro L-arginine (3 mg.kg-1) in normal (controls, 24 +/- 5%; bosentan, 10 +/- 3%; P < .01) or ganglion-blocked (controls, 86 +/- 13%; bosentan, 25 +/- 8%; P < .01) rats. Finally, L-NAME induced a modest increase in plasma levels of endothelin-1 (controls, 26.8 +/- 4.1 pg.mL-1; L-NAME, 38.5 +/- 3.3 pg.mL-1; P < .05).These experiments demonstrate that inhibition of NO synthesis unmasks a tonic pressor influence of endothelin, suggesting that this peptide could play a major role in pathophysiological situations associated with an impaired formation of NO.
The virtuosity of virtuality or how real is virtual colonography
Authors: H Herfarth
Journal: Gut (2003)

Virtual colonoscopy can be considered as work in progress and may be the state of the art technique for a non-invasive and perhaps even pleasant colonoscopy in the future 

The term “virtual colonoscopy” was initially coined by Vinig et al in 1994 who demonstrated the feasibility of creating three dimensional pictures of the colon using spiral computed tomography (CT) technology.1 Since the term “virtual colonoscopy” is misleading and implies a colonoscopic procedure rather than generation of images, this methodology should be referred to as virtual colonography (VC). VC can be performed using CT or magnetic resonance imaging (MRI). In this issue of Gut , Ajaj and colleagues2 present an evaluation of a new MR colonography technique employing a water enema for contrasting and extending the colon [see page 1738] . The so called “dark lumen” technique, which was first published in a small feasibility study3 and further described in a recently published review by the same group,4 offers the advantage that the lumen of the colon is pictured black whereas the colonic wall as well as polyps are brightly enhanced in T1 weighted sequences following the application of intravenous paramagnetic contrast. So what is the difference between this technique and that used in other published MR colonography studies? The common procedure is still administration of enemas mixed with paramagnetic contrast such as gadolinium, resulting in a “white” lumen in the T1 sequences. The high bright intraluminal signal contrasts with the black signal of the colonic wall; however, air bubbles and residual faeces also appear black with this technique, necessitating collecting data sets from both the prone and supine patient positions to differentiate real “sessile” polyps from “wandering” air bubbles or faeces. Hence the advantages of the “black lumen” are obvious. Because of the bright appearance …
Crosswalk Markings and Motor Vehicle Collisions Involving Older Pedestrians
Authors: Jeffrey W. Runge
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses
Authors: Sofia Papadia, Francesc X Soriano, Frédéric Léveillé, Marc-Andre Martel, Kelly A Dakin, Henrik H Hansen, Angela Kaindl, Marco Sifringer, Jill Fowler, Vanya Stefovska, Grahame Mckenzie, Marie Craigon, Roderick Corriveau, Peter Ghazal, Karen Horsburgh, Bruce A Yankner, David J A Wyllie, Chrysanthy Ikonomidou, Giles E Hardingham
Journal: Nature Neuroscience (2008)
More Conflicts of Interest: Review Articles Sponsored by the Pharmaceutical Industry-Reply
Authors: Lawrence O. Gostin
Journal: JAMA (1994)

<h3>In Reply.</h3> —In the context raised by Dr Nahata, industry support for the publication of a review article should be viewed as part of a company's marketing efforts, namely, to provide an incentive for a professional to publish his or her opinion about the company's product. Presumably, the company's fiscal motives are to encourage others to rely on the author's assessment of the product and, thus, influence sales. Companies may benefit most from supporting well-written articles by skeptical academics who happen to agree with company positions. Nahata differs from our view insofar as he suggests that the content of such articles are controlled by the sponsoring company. Product endorsement articles lacking objectivity seldom survive journal peer review processes. Further, most scholars realize that it reflects poorly on their academic career if objectivity and professionalism are influenced by financial inducements. Many peer-reviewed publications, including<i>JAMA</i>, require authors to disclose sources of
Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: A randomized phase II trial for safety and optimal dosage
Authors: Chun-Jen Liu, Po-Huang Lee, Deng-Yn Lin, Cheng-Chung Wu, Long-Bin Jeng, Pin-Wen Lin, King-Tong Mok, Wei-Chen Lee, Hong-Zen Yeh, Ming-Chih Ho, Sheng-Shun Yang, Ching-Chih Lee, Ming-Chin Yu, Rey-Heng Hu, Cheng-Yuan Peng, Kuan-Lang Lai, Stanley Shi-Chung Chang, Pei-Jer Chen
Journal: Journal of Hepatology (2009)
Intradermal Test in the Detection of Trichinosis
Authors: James E. Maynard, Irving G. Kagan
Journal: New England Journal of Medicine (1964)

DURING the fall and winter of 1960–61, among Eskimo families at Bethel and Goodnews Bay, Alaska, there was an outbreak of trichinosis, totaling 24 cases, due to the ingestion of the meat of both black and brown bear. All cases were confirmed serologically and epidemiologically, and included 18 clinical and 6 subclinical infections. A report of these 2 outbreaks, with an evaluation of serodiagnosis and a review of the Arctic ecology of Trichinella spiralis, has been published elsewhere.1 In the original epidemiologic investigation, an intracutaneous test using a standard commercial preparation§ was performed in 23 documented cases one to . . .
Double Pulsion Diverticula of the Pharyngoesophageal Junction
Authors: Edward R. Munnell
Journal: JAMA (1961)

PULSION diverticula of the pharyngoesophageal junction are reported with some frequency. It is suggested that the incidence is approximately 3% of patients appearing for x-ray examination for disturbances of swallowing. 12 An apparently rare variety of pharyngoesophageal diverticulum is one that presents as two separate lesions. An unusual case of double diverticula of the pharyngoesophageal junction is reported below.  Report of a Case  A 68-year-old woman was admitted to the Wesley Hospital, Oklahoma City, Okla., in September 1959, with a 3-month history of recurrent coughing, choking, and regurgitation of previously ingested food. Her symptoms had become progressively worse, and one week prior to admission x-ray examination had shown two pulsion diverticula of the upper esophagus (Fig. 1).  Her history revealed a thyroidectomy in 1938 for benign goiter, which had been followed by the need for treatment with desiccated thyroid. Postoperatively, she had also developed tetany and had habitually taken