tbuckley/cabot-search huggingface dataset:
Septic Arthritis with Pseudomonas stutzeri
Authors: T. MADHAVAN
Journal: Annals of Internal Medicine (1974)

Letters1 May 1974Septic Arthritis with Pseudomonas stutzeriT. MADHAVAN, M.D.T. MADHAVAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-5-670_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor:Pseudomonas stutzeriis a Gram-negative, aerobic, nonfluorescent pseudomonad that is identified by its colonial morphology and production of nitrogen gas. The strain is diphasic and consists of both rough and smooth colonial forms, many producing a characteristic yellow pigment. Other distinctive characteristics are starch hydrolysis, growth on 6.5% sodium chloride, assimilation of maltose and sucrose, inability to produce acid from sucrose and lactose, and inability to grow at a pH of 5.6 (1). This organism has been isolated from clinical specimens and hospital environments but is usually considered to be nonpathogenic and a common laboratory contaminant (2)....References1. GILARDI G: Characterization of Pseudomonas species isolated from clinical specimens. Appl Microbiol 21:414-419, 1971 CrossrefMedlineGoogle Scholar2. SUTTER V: Identification of Pseudomonas species isolated from clinical environment and human sources. Appl Microbiol 16:1535-1540, 1968 CrossrefGoogle Scholar3. MOODY M, YOUNG V, and KENTON D: In vitro antibiotic susceptibility of pseudomonads other than Pseudomonas aeroginosa recovered from cancer patients. Antimicrob Agents Chemother 2:344-349, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: T. MADHAVAN, M.D.Affiliations: Division of Infectious Diseases Henry Ford Hospital Detroit, Michigan 48202 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA propósito de un caso: Pseudomonas stutzeri, una causa inusual de artritis sépticaA Case Report: Pseudomonas Stutzeri, An Unusual Cause of Septic ArthritisProsthetic vascular graft infection and prosthetic joint infection caused by Pseudomonas stutzeriPseudomonas stutzeri knee arthritis in a child: case report and reviewClinical microbiological case: facial inflammation in a child with a subnormal serum concentration of IgG2Pseudomonas stutzeri infection a review of hospital isolates and a review of the literatureIdentification and distribution of Pseudomonas stutzeri in clinical materialHuman- and Animal-Pathogenic Members of the Genus PseudomonasArthritis due to Gram-Negative Bacilli 1 May 1974Volume 80, Issue 5Page: 670-671KeywordsArthritisLactosePseudomonasResearch laboratoriesSodium chlorideStarchesSucrose ePublished: 1 December 2008 Issue Published: 1 May 1974 PDF downloadLoading ...
Clinical Problems Arising from the Laboratory Control of Anticoagulant Therapy.
Authors: B. H. Pastor
Journal: Annals of Internal Medicine (1963)

s1 April 1963Clinical Problems Arising from the Laboratory Control of Anticoagulant Therapy.B. H. Pastor, M.D., F.A.C.P., T. Rodman, M.D., F.A.C.P.B. H. Pastor, M.D., F.A.C.P.Search for more papers by this author, T. Rodman, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-713_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe aboratory control of anticoagulant therapy presents many complex problems of major clinical importance. The most perplexing of these is the lack of exact knowledge concerning the factor or factors which must be regulated to prevent intravascular thrombosis or undesirable bleeding. Without this precise information the clinician is dependent upon tests which reflect those factors known to be concerned in the clotting mechanism and presumed to be of importance in clinical anticoagulation. The clinician's problem is further compounded by the variety of tests available and by laboratory inaccuracies which may lead either to inadequate therapy or to serious hemorrhagic complications.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 713-714KeywordsAnticoagulant therapyHemorrhageResearch laboratoriesThrombosis Issue Published: 1 April 1963 PDF DownloadLoading ...
miR-155 Activates Cytokine Gene Expression in Th17 Cells by Regulating the DNA-Binding Protein Jarid2 to Relieve Polycomb-Mediated Repression
Authors: Thelma M. Escobar, Chrysi Kanellopoulou, David G. Kugler, Gokhul Kilaru, Cuong K. Nguyen, Vijayaraj Nagarajan, Ravikiran K. Bhairavabhotla, Daniel Northrup, Rami Zahr, Patrick Burr, Xiuhuai Liu, Keji Zhao, Alan Sher, Dragana Jankovic, Jinfang Zhu, Stefan A. Muljo
Journal: Immunity (2014)
Systemic Sclerosis-associated Pulmonary Arterial Hypertension
Authors: Jérôme Le Pavec, Marc Humbert, Luc Mouthon, Paul M. Hassoun
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Pulmonary arterial hypertension (PAH) is a devastating vascular complication of a number of connective tissue diseases, including systemic sclerosis (SSc), where it has a dramatic impact on the clinical course and overall survival and is the single most common cause of death in patients afflicted with this syndrome. Although remarkable advances have been achieved in elucidating the pathogenesis of PAH over the past 2 decades, leading to the development of disease-targeted therapies for the idiopathic form of this condition (IPAH), the response to therapy is suboptimal in SSc-related PAH (SSc-PAH), and survival remains very poor. Factors accounting for striking clinical and prognostic differences between these two syndromes are unclear but may include a more pronounced autoimmune, cellular, and inflammatory response, and a higher prevalence of comorbidities in SSc-PAH, including cardiac and pulmonary venous and parenchymal involvement. Furthermore, currently available markers of disease severity and clinical tools to assess response to therapy, which may be reliable in IPAH, are either limited or lacking in SSc-PAH. Thus, a more focused approach, including a better understanding of the pathogenesis and genetic factors underlying the development of SSc-PAH, a search for more specific and reliable tools to adequately assess functional impairment and monitor therapy, as well as the design of novel targeted therapies, are all urgently required to alter the dismal course of this syndrome.
Death with Dignity: A Case Study
Authors: Walter J. Kade
Journal: Annals of Internal Medicine (2000)

On Being a Doctor21 March 2000Death with Dignity: A Case StudyWalter J. Kade, MDWalter J. Kade, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-6-200003210-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I voted twice against legislative measures in Oregon that would allow physician-assisted suicide. Within months after the Death with Dignity Act became law, I received a call from the parents of a patient of mine requesting that I assist their daughter in her suicide.My patient was then only 29 years old, but she seemed much older and wiser. I had diagnosed her non-Hodgkin lymphoma almost 10 years earlier. She was not only bright but also intensely perceptive and private. With a thin, angled countenance, thick, dark hair, and rich, introspective eyes, she was a startlingly handsome young woman. For ...Reference1. Haley K, Lee M, eds. The Oregon Death with Dignity Act: A Guidebook for Health Care Providers. Portland, OR: The Center for Ethics in Health Care, Oregon Health Sciences University; 1998. Google Scholar Author, Article, and Disclosure InformationAffiliations: Editor's Note: The family of the patient described here gave permission to publish this report. At the family's request, however, the author agreed that his real name would not be used. Walter J. Kade is a pseudonym. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA Philosophical View on the Experience of Dignity and Autonomy through the Phenomenology of IllnessCultural Differences in Shame and Guilt as Understandable Reasons for SuicidePatient Perspectives of Dignity, Autonomy and Control at the End of Life: Systematic Review and Meta-EthnographyNew Zealanders' Attitudes toward Physician-Assisted DyingSuicide in Later LifeEuthanasia tactics: patterns of injustice and outrageDignity TherapyLearning from dying patients during their final days: life reflections gleaned from dignity therapyThe Traditional Account of Ethics and Law at the End of Life—and its DiscontentsDignity and health: A reviewA CRITICAL ANALYSIS OF CRITICISMS OF THE OREGON DEATH WITH DIGNITY ACTDefining dignity in terminally ill cancer patients: A factor-analytic approachDignity and Psychotherapeutic Considerations in End-of-Life CareOregon Physicians' Responses to Requests for Assisted Suicide: A Qualitative StudyDying with dignity: The good patient versus the good deathTake Some Time to Look Inside Their HeartsDignity in the terminally ill: a developing empirical modelPhysician-assisted dying: Review of issues and roles for health psychologists. 21 March 2000Volume 132, Issue 6Page: 504-506KeywordsDecision makingEmotionsIngestionPainShockSleepSuicideSweatThoraxVomiting ePublished: 15 August 2000 Issue Published: 21 March 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A Physician's Guide to Adoption
Authors: Nancy K. O'Connor
Journal: JAMA (1988)

<h3>To the Editor.</h3> —The article entitled "A Physician's Guide to Adoption"1 in the Dec 25, 1987, issue of<i>JAMA</i>ignores many aspects of adoption. Although there were good discussions of infertile childless couples adopting babies and toddlers and of black couples adopting black children, there was no mention of other types of adoptive parents or children. For example, there was no discussion of adoption by Hispanics or Native Americans, which was surprising in view of the fact that two of the authors live in areas with large Hispanic populations. Single-parent adoption, which is not uncommon, was not addressed. There was no attention given to families with children (by adoption or by birth) who decide to expand their families through adoption or to foster families who adopt the children they care for. There was no mention of men who adopt. This is especially important because the most common type of adoption
Role of Oxidative Stress in Ultrafine Particle–induced Exacerbation of Allergic Lung Inflammation
Authors: Francesca Alessandrini, Ingrid Beck-Speier, Daniel Krappmann, Ingrid Weichenmeier, Shinji Takenaka, Erwin Karg, Bernhard Kloo, Holger Schulz, Thilo Jakob, Martin Mempel, Heidrun Behrendt
Journal: American Journal of Respiratory and Critical Care Medicine (2009)

The effects of ultrafine particle inhalation on allergic airway inflammation are of growing interest. The mechanisms underlying these effects are currently under investigation.To investigate the role of oxidative stress on the adjuvant activity of inhaled elemental carbon ultrafine particles (EC-UFPs) on allergic airway inflammation.Ovalbumin-sensitized mice were exposed to EC-UFPs (504 microg/m(3) for 24 h) or filtered air immediately before allergen challenge and systemically treated with N-acetylcysteine or vehicle before and during EC-UFP inhalation. Allergic inflammation was measured up to 1 week after allergen challenge by means of bronchoalveolar lavage, cytokine/total protein assays, lung function, and histology. Isoprostane levels in lung tissue served to measure oxidative stress. Transmission electron microscopy served to localize EC-UFPs in lung tissue and both electrophoretic mobility shift assay and immunohistochemistry to quantify/localize nuclear factor-kappaB (NF-kappaB) activation.In sensitized and challenged mice EC-UFP inhalation increased allergen-induced lung lipid peroxidation and NF-kappaB activation in addition to inflammatory infiltrate, cytokine release, and airway hyperresponsiveness. Prominent NF-kappaB activation was observed in the same cell types in which EC-UFPs were detected. N-acetylcysteine treatment significantly reduced the adjuvant activity of EC-UFPs. In nonsensitized or sensitized but not challenged mice EC-UFP exposure induced a moderate increase in isoprostanes but no significant effect on other parameters of lung inflammation.Our findings demonstrate a critical role for oxidative stress in EC-UFP-induced augmentation of allergen-induced lung inflammation, where EC-UFP exposure has potentiating effects in lung allergic inflammation. Our data support the concept that allergic individuals are more susceptible to the adverse health effects of EC-UFPs.
Continuous Basal Insulin Infusion: An Effective Means to Achieve Good Glycemic Control Without Premeal Boluses
Authors: John A Duncan, John I Malone
Journal: Diabetes Care (1984)

In 11 insulin-dependent diabetic subjects, aged 12-32 yr, we evaluated the efficacy of dual, basal-rate pump delivery of insulin without preprandial boluses. Mean HbA1c fell from 11.6 +/- 3.1% to 7.7 +/- 1.8% at 30 days (P less than 0.005), and remained at 7.1 +/- 1.3% at the time of this evaluation (mean duration of therapy, 6.6 mo). These data suggest that dual-rate continuous basal insulin infusion is an effective means of achieving good diabetes control. Furthermore, it is simpler than the preprandial bolus approach currently used, which may make it suitable for more patients.
The persistence of allergic contact sensitivity: a 10-year follow-up in 100 patients
Authors: K. KECZKES, A.M. BASHEER, E.H. WYATT
Journal: British Journal of Dermatology (1982)

One hundred patients with 161 positive patch test reactions to a number of common allergic sensitizers were re‐examined after a period of 10 years, using the same patch test technique. Out of 161 positive patch test reactions, ninety‐four (59%) remained positive, forty‐four (27%) had diminished reactivity and twenty‐two (14%) had become negative.
Abstract 515: G12 overexpression in hepatocellular carcinoma promotes epithelial-mesenchymal transition through microRNAs deregulation
Authors: Sang Geon Kim, Yoon Mee Yang, Tae Hyun Kim, Chan Gyu Lee, Jihyun An, Sung Hoon Kim, Chang H. Lee, Sejin Hwang, Seung Jin Lee, Kang M. Kim
Journal: Cancer Research (2014)

Abstract Hepatocellular carcinoma (HCC) has a poor prognosis due to its aggressive nature. Ligand activation of G-protein coupled receptor with enhanced G-protein activity may contribute to tumorigenesis and tumor progression in microenvironments. Here, we report the overexpression of Gα12 in HCC and its effect on deregulation of microRNAs in association with epithelial-mesenchymal transition. Gα12 expression levels were higher in human HCC than surrounding normal tissue. Array analyses using Huh7 cells stably transfected with an active mutant of Gα12 (Gα12QL) enabled us to extract down-regulated microRNAs. Of them, decreases of miR-200b/a, -192 and -215 contributed to ZEB induction through the up-regulation of MDM2. Transfection with miR-200b, -192 or miR-215 mimic antagonized HCC cell migration and invasion facilitated by Gα12QL. In tumor xenograft studies, sustained knockdown of Gα12 decreased the overall growth rate and average volume of tumors derived from SK-Hep1, a mesenchymal liver tumor cell line. In human HCC samples, levels of the identified microRNAs were all decreased, and correlated with the induction of mesenchymal markers. Moreover, decreases of the miRNAs discriminated microvascular invasion versus non-microvascular invasion of HCC. Conclusion: Increase of Gα12 in HCC deregulates a set of miRNAs promoting epithelial-mesenchymal transition of HCC and may be responsible for tumor microvascular invasion, implying that Gα12 signaling and the downstream mediators may be utilized as therapeutic targets and/or prognostic markers. Citation Format: Sang Geon Kim, Yoon Mee Yang, Tae Hyun Kim, Chan Gyu Lee, Jihyun An, Sung Hoon Kim, Chang Ho Lee, Sejin Hwang, Seung Jin Lee, Kang Mo Kim. G12 overexpression in hepatocellular carcinoma promotes epithelial-mesenchymal transition through microRNAs deregulation. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 515. doi:10.1158/1538-7445.AM2014-515
Remembering Homer Smith
Authors: Carl W. Gottschalk, Robert W. Berliner
Journal: Kidney International (1993)

Editor's Note: This Historical Archives is a particularly apt contribution, since 1992 marked the thirtieth anniversary of the death of Homer William Smith. Professor Smith was born on January 2, 1895 and succumbed on March 25, 1962. There is little doubt that he is one of the truly major figures in nephrology. His book,  Kidney: Structure and Function in Health and Disease, published in 1951 and affectionately known as The Green Book to a generation of renal physiologists and renal clinicians, is one of the pivotal renal texts of this century. THE EDITORS
The Association Between Chlamydia trachomatis and Ectopic Pregnancy
Authors: Joan M. Chow
Journal: JAMA (1990)

We performed a case-control study of the association of past exposure to Chlamydia trachomatis and ectopic pregnancy with 306 case patients with an ectopic pregnancy and 266 pregnant patients who served as controls. The geometric mean antichlamydial antibody titer among cases was 75 +/- 10.2 vs 13 +/- 11.0 among controls. The matched-pair odds ratio for ectopic pregnancy and IgG titer of 1:64 or greater to C trachomatis was 3.0 (95% confidence interval, 2.1 to 4.4). Adjusting for age at first intercourse, total lifetime partners, douching, history of infertility, and parity yielded a relative risk of 2.4 (95% confidence interval, 1.5 to 3.3). Current douching remained an independent risk factor after controlling for chlamydial exposure, with an adjusted relative risk of 2.1 (95% confidence interval, 1.3 to 3.5). The population attributable fraction for chlamydial infection was 0.47 and that for douching was 0.45. The results stress the need for control of C trachomatis infections and for further study of specific douching behaviors as risk factors for ectopic pregnancy.
Cell penetrating peptides improve tumor delivery of cargos through neuropilin-1-dependent extravasation
Authors: Tetsuya Kadonosono, Akihiro Yamano, Toshiki Goto, Takuya Tsubaki, Mizuho Niibori, Takahiro Kuchimaru, Shinae Kizaka-Kondoh
Journal: Journal of Controlled Release (2015)
THE "WHEAT-STUBBLE SARCOID GRANULOMA": A NEW EPITHELIOID GRANULOMA OF THE SKIN
Authors: J. CORTEZ PIMENTEL
Journal: British Journal of Dermatology (1972)

Journal Article THE “WHEAT‐STUBBLE SARCOID GRANULOMA”: A NEW EPITHELIOID GRANULOMA OF THE SKIN Get access J. CORTEZ PIMENTEL J. CORTEZ PIMENTEL I.A.N.T. (Department of Pathology of Sanatorio D. Carlos I) and Institute of Pathology, Faculty of Medicine, University of Lisbon, Portugal Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 87, Issue 5, 1 November 1972, Pages 444–449, https://doi.org/10.1111/j.1365-2133.1972.tb01592.x Published: 01 November 1972 Article history Accepted: 22 April 1972 Published: 01 November 1972
Glucocorticoid-induced leucine zipper: A key protein in the sensitization of monocytes to lipopolysaccharide in alcoholic hepatitis
Authors: Haifa Hamdi, Amélie Bigorgne, Sylvie Naveau, Axel Balian, Laurence Bouchet-Delbos, Anne-Marie Cassard-Doulcier, Marie-Christine Maillot, Ingrid Durand-Gasselin, Sophie Prévot, Jocelyne Delaveaucoupet, Dominique Emilie, Gabriel Perlemuter
Journal: Hepatology (2007)

Glucocorticoid-induced leucine zipper (GILZ), a recently identified protein induced by glucocorticoids (GCs), inhibits the nuclear factor kappaB pathway and the activation of monocytes/macrophages by lipopolysaccharides (LPS). This study aimed to elucidate the contribution of GILZ to the pathogenesis of alcoholic hepatitis (AH): we (1) assessed GILZ expression in the livers of patients with AH and (2) treated patients with severe AH with GCs (prednisolone 40 mg/day) and studied the effect of GILZ modulation on circulating monocyte function. We quantified GILZ expression in the livers of 42 consecutive alcoholic patients (21 with and 21 without AH). GILZ messenger RNA (mRNA) levels were lower in the livers of patients with AH versus those without AH (P < 0.05). We collected circulating monocytes from patients with severe AH before and 48 hours after GC treatment to quantify GILZ expression and cytokine secretion. GC treatment induced significantly higher levels of GILZ mRNA than that observed before treatment and impaired LPS-induced tumor necrosis factor-alpha (TNF-alpha) and regulated upon activation, normal T cell-expressed secretion (RANTES) by these monocytes. We transfected circulating monocytes with GILZ small interfering RNA (siRNA), specifically blocking GILZ expression, to demonstrate the role of GILZ in mediating GC effect. GILZ siRNA abrogated the effect of GC treatment on LPS-induced TNF-alpha and RANTES secretion.Low expression of GILZ may contribute to liver inflammation in AH. GCs enhance GILZ expression, abrogating macrophage sensitivity to LPS and proinflammatory cytokine secretion. These findings may explain the beneficial effect of GC treatment in patients with severe AH.
Need to increase focus on non-communicable diseases in global health, says WHO
Authors: J. Zarocostas
Journal: BMJ (2010)

Governments worldwide need to increase the priority given to fighting non-communicable diseases especially in the poorest nations, the World Health Organization says.

The sense of urgency by WHO is driven by the high and projected increases in the prevalence rates of non-communicable diseases—cardiovascular diseases, cancers, diabetes, and chronic lung diseases.

These four major groups of diseases share four risk factors—tobacco use, unhealthy diet, physical inactivity, and the harmful use of alcohol.

Ala Alwan, WHO’s top official for non-communicable diseases and mental health, said, “The reason for the focus on these four major group …
Polycaprolactone scaffold and reduced rhBMP-7 dose for the regeneration of critical-sized defects in sheep tibiae
Authors: Amaia Cipitria, Johannes C. Reichert, Devakar R. Epari, Siamak Saifzadeh, Arne Berner, Hanna Schell, Manav Mehta, Michael A. Schuetz, Georg N. Duda, Dietmar W. Hutmacher
Journal: Biomaterials (2013)
Human interleukin 10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3.
Authors: F Brière, C Servet-Delprat, J M Bridon, J M Saint-Remy, J Banchereau
Journal: The Journal of Experimental Medicine (1994)

During antigen-induced immune responses, human B cells switch isotype from immunoglobulin M (IgM)-IgD to IgG1-4, IgA1-2, or IgE. In the human, no cytokines have yet been demonstrated to act as switch factors for IgG1, IgG2, and IgG3. In this paper, we report that in response to interleukin 10 (IL-10), anti-CD40 activated tonsillar surface IgD+ (sIgD+) B cells are induced to secrete large amounts of IgM, IgG1, and IgG3 but neither IgG2 nor IgG4. Cord blood purified B cells and lymphocytes from Hyper-IgM patients also produced IgG1 and IgG3 after culture with anti-CD40 and IL-10. In contrast, sIgD- isotype-committed B cells produce IgG1, IgG2, and IgG3 when activated through CD40 in the presence of IL-10. Thus, in addition to its growth-promoting and differentiating activities on human B cells, IL-10 may represent a switch factor for IgG1 and IgG3.