Patterns of Polymyositis and Their Responses to Treatment
Authors: CARL M. PEARSON
Journal: Annals of Internal Medicine (1963)

Article1 December 1963Patterns of Polymyositis and Their Responses to TreatmentCARL M. PEARSON, M.D., F.A.C.P.CARL M. PEARSON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-6-827 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPolymyositis encompasses a group of disorders, of unknown cause, in which muscular weakness is the principal clinical feature. They are the most common primary myopathies that begin in adult life. Pathologically degenerative and inflammatory changes are found in the muscles in these conditions (1), while the most characteristic clinical laboratory finding is an elevation of serum enzymes such as serum glutamic oxaloacetic transaminase or serum glutamic pyruvic transaminase, aldolase, creatine phosphokinase, lactic dehydrogenase, and other enzymes that normally reside within the muscle fibers. These are apparently released during the disease process and serve both as helpful tools for diagnosis and...References1. ADAMSDENNY-BROWNPEARSON RDDCM: Diseases of Muscle: a Study in Pathology, 2nd ed., Paul B. Hoeber, Inc., New York, 1962. Google Scholar2. PEARSON CM: Polymyositis: clinical forms, diagnosis and therapy. Postgrad. Med. 31: 450, 1962. CrossrefMedlineGoogle Scholar3. O'LEARYWAISMAN PAM: Dermatomyositis: a study of 40 cases. Arch. Derm. Syph. (Berlin) 41: 1001, 1940. CrossrefGoogle Scholar4. PEARSON CM: Rheumatic manifestations of polymyositis and dermatomyositis. Arthritis Rheum. 2: 127, 1959. CrossrefMedlineGoogle Scholar5. WALTONADAMS JNRD: Polymyositis, E. & S. Livingstone, Ltd., Edinburgh (The Williams & Wilkins Company, Baltimore), 1958. Google Scholar6. EATON LM: The perspective of neurology in regard to polymyositis: a study of 41 cases. Neurology 4: 245, 1954. CrossrefMedlineGoogle Scholar7. 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Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CARL M. PEARSON, M.D., F.A.C.P.Affiliations: Los Angeles, CaliforniaFrom the Department of Medicine, University of California School of Medicine, and Wadsworth Hospital, Veterans Administration Center, Los Angeles, California.These studies were supported in part by a grant from the Muscular Dystrophy Associations of America, Inc.Presented at the 44th Annual Session of the American College of Physicians, Denver, Colorado, April 15, 1963.Requests for reprints should be addressed to Carl M. Pearson, M.D., Department of Medicine, University of California School of Medicine, Los Angeles 24, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byImmunosuppressive and immunomodulatory therapies for neuromuscular diseases. Part I: Traditional agentsDeviation in the recovery of the lower limb and respiratory muscles of patients with polymyositis: a preliminary clinical studyHistopathologic Findings in 5 Patients With Hypomyopathic DermatomyositisProgress and prognosis in juvenile dermatomyositisHigher proportion of fast-twitch (type II) muscle fibres in idiopathic inflammatory myopathies - evident in chronic but not in untreated newly diagnosed patientsThe ‘Connective Tissue Diseases’Targeted Treatment of the Idiopathic Inflammatory MyopathiesAmyopathic DermatomyositisNutrition and Polymyositis and DermatomyositisClassification criteria in rheumatic diseases: A review of methodologic propertiesA systematic review of juvenile-onset clinically amyopathic dermatomyositisManagement of Cutaneous DermatomyositisGeneralized myositis mimicking polymyositis associated with chronic active Epstein-Barr virus infectionCorticosteroid use in the treatment of neuromuscular disorders: Empirical and evidence-based dataAn Autopsy Case of Dermatomyositis with Severe DysphagiaVesiculobullous dermatomyositis with panniculitis without muscle diseaseDifferentiating idiopathic inflammatory myopathies from metabolic myopathiesWould a new name hasten the acceptance of amyopathic dermatomyositis (dermatomyositis siné myositis) as a distinctive subset within the idiopathic inflammatory dermatomyopathies spectrum of clinical illness?Treatment and investigation of idiopathic inflammatory myopathiesDermatomyositisJuvenile DermatomyositisGender and Underlying Diseases Affect the Frequency of the Concurrence of Adult Polymyositis/Dermatomyositis and Interstitial PneumoniaAdult onset polymyositis/dermatomyositis: clinical and laboratory features and treatment response in 75 patients.Cutaneous changes of dermatomyositis in patients with normal muscle enzymes: Dermatomyositis sine myositis?Analysis of Lymphocyte Subpopulations in Peripheral Blood in Adult and Juvenile Cases of DermatomyositisA Case of Corticosteroid Resistant Dermatomyositis with Esophageal Dysfunction.The Concomitant Occurrence of Sjögren's Syndrome and PolymyositisAmyopathic dermatomyositis (dermatomyositis siné myositis)Polymyositis: A Case History Approach to the Differential Diagnosis and TreatmentAdult-onset polymyositis-dermatomyositis: Description of 25 patients with emphasis on treatmentDermatomyositis and MalignancyCutaneous changes of dermatomyositis precede muscle weaknessPerifascicular atrophic fibers in childhood dermatomyositis with particular reference to mitochondrial changesApparent haematuria: an early sign in polymyositisHistory and classification of polymyositis and dermatomyositisClinical Presentation and Diagnosis of Polymyositis and DermatomyositisAssociation of Inflammatory Myopathies with Other Connective Tissue Disorders and MalignanciesTreatment of Polymyositis and Dermatomyositis with Corticosteroids: A First Therapeutic ApproachParaneoplastic Syndromes Associated with Prostatic CarcinomaDermatomyositisAntibody-Mediated Membrane Abnormalities in Polymyositis: Reduction of Acetylcholine Receptors by ImmunoglobulinThe use of corticosteroid agents in connective tissue disorders ∗Discordance of Skin and Muscle Involvement in DermatomyositisEvaluation of the patient with Raynaud's phenomenonPrognostic factors in polymyositis/dermatomyositis. A computer-assisted analysis of ninety-two casesPolymyositis: Reduction of acetylcholine receptors in skeletal musclePrognosis and treatment of polymyositis with particular reference to steroid resistant patients.Discordance of Skin and Muscle Involvement in DermatomyositisCourse of treated juvenile dermatomyositisSystemic LupusPolymyositis—Clinical TrialsDermatomyositisInfantile MyositisTherapie autoimmunogener MuskelerkrankungenUreteral Diverticulosis in a Case of DermatomyositisEvolution et pronostic à long terme de 50 cas de dermatomyosites et polymyositesAzathioprine with Prednisone for Polymyositis A Controlled, Clinical TrialTHOMAS W. BUNCH, M.D., JOHN W. WORTHINGTON, M.D., JOSEPH J. COMBS, M.D., DUANE M. ILSTRUP, M.S., ANDREW G. ENGEL, M.D.Dermatomyositis without Apparent Myositis, Complicated by Fibrosing AlveolitisDermatomyositis: observations on the use of immunosuppressive therapy and review of literature. Cairo—Glasgow study groupSpontaneous pneumothorax: A complication of juvenile dermatomyositisMuscle disease in progressive systemic sclerosis. diagnostic and therapeutic considerationsTubular cytoplasmic inclusions in a case of childhood dermatomyositis with migratory subcutaneous nodulesAcute dermatomyositis-polymyositis and malignancyThe Spectrum of Polymyositis and DermatomyositisDeforming arthritis of the hands in polymyositisDermatomyositis and Malignancy A Review of the LiteratureBARBARA E. BARNES, M.D.Prognosis in adult polymyositisVasospastic diseases: A reviewPolymyositis and DermatomyositisFibrosing alveolitis in polymyositisPolymyositis and Dermatomyositis: Combined Methotrexate and Corticosteroid TherapyALLAN L. METZGER, M.D., ANTHONY BOHAN, M.D., LEONARD S. GOLDBERG, M.D., F.A.C.P., RODNEY BLUESTONE, M.B., F.A.C.P., CARL M. PEARSON, M.D., F.A.C.P.Progressive Muskeldystrophien unter besonderer Berücksichtigung der Creatin-KinaseFatal polymyositis: Morphogenesis and ultrastructural featuresDermatomyositisPolymyositis with vesical dysfunctionPrognosis in childhood dermatomyositisTHE SYNDROME OF MYASTHENIA AND POLYMYOSITIS WITH COMMENTS ON THERAPYFactors Affecting Survivorship in Polymyositis. A Life-Table Study of 124 PatientsMalignancy and ArteriopathyGLUCOCORTICOIDS IN THE CONNECTIVE TISSUE DISEASESDermatomyositis and Malignant Effusions: Rare Manifestations of Carcinoma of the ProstateTREATMENT OF DERMATOMYOSITIS WITH METHOTREXATERecent Advances in the Rheumatic DiseasesEPHRAIM P. ENGLEMAN, M.D., F.A.C.P., MARTIN A. SHEARN, M.D., F.A.C.P.Polymyositis: A Clinical StudyR. G. LOGAN, M.D., J. M. BANDERA, M.D., W. M. MIKKELSEN, M.D., F.A.C.P., I. F. DUFF, M.D., F.A.C.P.Entero-arthropathy: The Coexistence of Articular and Gastrointestinal Manifestations in Systemic DiseaseA CASE OF DERMATOMYOSITIS TREATED WITH 6‐MERCAPTOPURINE AND AZATHIOPRINEPolymyalgia rheumatica 1 December 1963Volume 59, Issue 6Page: 827-838KeywordsDermatomyositisDysphagiaEnzymesHospital medicineMusclesMuscular dystrophiesMuscular weaknessPolymyositisSerum glutamic oxaloacetic transaminaseSerum glutamic pyruvic transaminase ePublished: 1 December 2008 Issue Published: 1 December 1963 PDF downloadLoading ...