Histamine H-2 Receptor Antagonists
Authors: BASIL I. HIRSCHOWITZ
Journal: Annals of Internal Medicine (1977)

Editorials1 September 1977Histamine H-2 Receptor AntagonistsBASIL I. HIRSCHOWITZ, M.D., F.A.C.P., F.R.C.P., F.R.C.P. (EDIN)BASIL I. HIRSCHOWITZ, M.D., F.A.C.P., F.R.C.P., F.R.C.P. (EDIN)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-3-373 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe actions of histamine are mediated by two types of receptors that are present on a number of morphologically distinct cell types (1). Those mediating mepyramine-sensitive histamine responses are defined as H-1 receptors. H-2 receptors, which mediate histamine effects on gastric acid secretion, cardiac pacemaker, and a growing list of other actions (1), are blocked by a new class of compounds first synthesized by Black and colleagues (2). They have also described specific agonists for H-1 (2-methyl histamine) and H-2 (4-methyl histamine) receptors. These and newer H-1 and H-2 specific agonists and antagonists have been used in a large number...References1. CHANDEYRE NP: Classification and biological distribution of histamine receptor subtypes. Agents Actions 5:277-295, 1975 CrossrefMedlineGoogle Scholar2. BLACKDUNCANDURANTGANELLINPARSONS JWGCM: Definition and antagonism of histamine H-2 receptors. Nature 236:385-390, 1972 CrossrefMedlineGoogle Scholar3. DURANTEMMETTGANELLIN GJC: The chemical origin and properties of histamine H-2 receptor antagonists, in Cimetidine: Proceedings of the Second International Symposium on Histamine H-2 Receptor Antagonists, edited by BURLAND WL, SIMKINS MA. Amsterdam, Excerpta Medica, 1977, pp. 1-12 Google Scholar4. GIBSONHIRSCHOWITZHUTCHISON RBG: Actions of metiamide, an H-2 histamine receptor antagonist, on gastric H+ and peptic secretion in dogs. Gastroenterology 67:93-99, 1974 CrossrefMedlineGoogle Scholar5. POUNDERWILLIAMSHUNTVINCENTMILTON-THOMPSONMISCIEWICZ RJRSGJ: The effects of oral Cimetidine on food-stimulated gastric acid secretion and 24 hour intragastric acidity, in Cimetidine: Proceedings of the Second International Symposium on Histamine H-2 Receptor Antagonists edited by BURLAND WL, SIMKINS MA. Amsterdam, Excerpta Medica, 1977, pp. 189-204 Google Scholar6. BURLANDSHARPECOLIN-JONESTURNBULLBOWSKILL WPDDP: Reversal of metiamide-induced agranulocytosis during treatment with Cimetidine (letter). Lancet 2:1085, 1975 CrossrefMedlineGoogle Scholar7. BURLANDSIMKINS WM (eds.): Cimetidine: Proceedings of the Second International Symposium on Histamine H-2 Receptor Antagonists. Amsterdam, Excerpta Medica, 1977, p. 392 Google Scholar8. GROSSMANFORDTRAN MJ (eds.): Third Symposium on Histamine H-2 Receptor Antagonists—Clinical Results with Cimetidine. To be published as a supplement in Gastroenterology, December 1977 Google Scholar9. BURLANDPARR WS: Experiences with Cimetidine in the treatment of seriously ill patients, in Cimetidine: Proceedings of the Second International Symposium on Histamine H-2 Receptor Antagonists, edited by BURLAND WL, SIMKINS MA. Amsterdam, Excerpta Medica, 1977, pp. 345-357 Google Scholar10. MACDOUGALLBAILEYWILLIAMS BRR: H-2 Receptor antagonists and antacids in the prevention of acute gastrointestinal haemorrhage in fulminant hepatic failure. Lancet 1:617-619, 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BASIL I. HIRSCHOWITZ, M.D., F.A.C.P., F.R.C.P., F.R.C.P. (EDIN)Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPERSPECTIVES OF THE PLACEBO PHENOMENON: General Medical Effectiveness and Human Biology: Placebo Effects in the Treatment of Ulcer DiseaseCimetidine and the immune responseEdible Symbols: The Effectiveness of PlacebosGreat reduction in renal function associated with cimetidineAndrological Problems in Gastrointestinal DisordersChronotropic and Dromotropic Effects of Histamine on the Canine HeartCimetidine and Arrhythmia SuppressionMOSHE LIGUMSKY, M.D., MARA SHOCHINA, M.D., DANIEL RACHMILEWITZ, M.D.Special Uses of CimetidineN. DABIR VAZIRI, M.D., CYRIL H. BARTON, M.D., RUSSELL NESS, M.D., KHOSROW MIRAHMADI, M.D. 1 September 1977Volume 87, Issue 3Page: 373-375KeywordsHistaminePacemakers ePublished: 1 December 2008 Issue Published: 1 September 1977 PDF downloadLoading ...