tbuckley/cabot-search huggingface dataset:
A mesangium-predominant gene, megsin, is a new serpin upregulated in IgA nephropathy.
Authors: T Miyata, M Nangaku, D Suzuki, R Inagi, K Uragami, H Sakai, K Okubo, K Kurokawa
Journal: Journal of Clinical Investigation (1998)

Mesangial cells play an important role in maintaining a structure and function of the glomerulus and in the pathogenesis of glomerular diseases. To identify a specific gene expressed in human mesangial cells, we used a rapid large-scale DNA sequencing and computerized data processing to compare the transcripts in cultured human mesangial cells with various different cells and organs. Using this novel approach, we discovered a new mesangium-predominant gene termed "megsin." We obtained a full-length cDNA clone of megsin, which coded for a novel 380-amino acid protein. Amino acid homology search revealed that megsin belonged to the serpin (serine protease inhibitor) superfamily. The amino acid sequences in the reactive loop site of megsin showed characteristic features of functional serpins. Northern blot and reverse-transcribed PCR analyses of various tissues and cells demonstrated that megsin was predominantly expressed in human mesangial cells. In situ hybridization studies showed the megsin expression in the mesangium of normal glomeruli, while it increased in the expanded mesangium of glomeruli from patients with IgA nephropathy with the degree of mesangial proliferation. Here we report a new human mesangium-predominant gene that may function as an inhibitory serpin in normal and abnormal biological processes of glomerulus.
Effect of uracil arabinoside on metabolism and cytotoxicity of cytosine arabinoside in L5178Y murine leukemia.
Authors: J L Yang, E H Cheng, R L Capizzi, Y C Cheng, T Kute
Journal: Journal of Clinical Investigation (1985)

Pretreatment of L5178Y murine leukemia cells with uracil arabinoside (ara-U) enhances the cytotoxicity of cytosine arabinoside (ara-C). This effect is mediated by the cytostatic effect of ara-U, which causes a delay of cell progression through S-phase. Consequently, the specific activity of enzymes that peak during S-phase increases, and deoxycytidine kinase increases 3.6-fold over untreated controls. This allows enhanced anabolism of ara-C to nucleotides, as well as increased incorporation into DNA with ultimate synergistic cytotoxicity. It is postulated that the systemic metabolism of high-dose ara-C to sustained high levels of ara-U in patients with acute leukemia may enhance the activity of subsequent doses of ara-C, and thus contribute to a means for pharmacologic self-potentiation, contributing to the unique therapeutic activity of high-dose ara-C.
Pulmonary Alveolar Microlithiasis: Radiographic and Scintigraphic Correlation
Authors: Tanmaya C. Shah, Arunabh Talwar, Rakesh D. Shah, Donald Margouleff
Journal: Clinical Nuclear Medicine (2007)

Pulmonary alveolar microlithiasis (PAM) is one of many causes of calcium deposition within the lungs. A rare condition, PAM describes an acquired process in which calcific bodies are deposited into the pulmonary alveolar space. The authors present the imaging findings of a patient with PAM. This case demonstrates how Tc-99m methylene diphosphonate (MDP) bone scintigraphy, in conjunction with chest radiography and computerized tomography, contributed to the diagnosis of PAM in a middle-aged woman who was initially misdiagnosed. Bone scintigraphy may add helpful information in the case of nonspecific CT findings. The usual picture is that of intense bilateral uptake of the radiopharmaceutical in the lungs.
Fatigue, facial flushing, and ankle and abdominal swelling in a 53 year old man
Authors: R. Abbott, H. R Dalton
Journal: BMJ (2008)

A 53 year old man presented with an 18 month history of fatigue, abdominal distension, and ankle swelling. Initial clinical examination, electrocardiography, chest radiography, and blood tests were unremarkable except for his liver enzymes, which showed a cholestatic pattern. Ultrasound and computed tomography scans of his abdomen showed mild hepatomegaly and a trace of ascites. A liver biopsy demonstrated non-specific inflammation and sinusoidal congestion. He recently developed flushing of his ears and face on bending forwards, which takes several minutes to clear on standing. At this stage he underwent magnetic resonance imaging of his chest (fig 1⇓). Fig 1 Magnetic resonance imaging scan of the patient’s chest ### Short answers Fig 2 Cardiac magnetic resonance imaging scan showing a thickened fibrotic pericardium as a black rim around the cardiac silhouette (arrow) surrounded by normal pericardial fat, which is white
A case of Lassa fever: clinical and virological findings.
Authors: R T Emond, B Bannister, G Lloyd, T J Southee, E T Bowen
Journal: BMJ (1982)

Five days after arriving in London from Jos a young Nigerian women developed a severe and prolonged illness that proved to be Lassa fever. Virus was not detected in urine during the first three weeks but then appeared and reached a peak during the sixth week, with continuing excretion for 67 days after the onset of illness. Laboratory investigations showed evidence of extensive tissue damage and disturbance of clotting, but there was no serious bleeding and she eventually made a complete recovery despite a high sustained viraemia and severe liver damage. Convalescent serum was used in treatment but it was difficult to assess its contribution to the favourable outcome.
NHS librarians cannot access the internet
Authors: D. Carnall
Journal: BMJ (1999)

Managerial paranoia and obstruction are some of the main reasons preventing hospital libraries from obtaining information from the internet, according to an informal survey conducted by OMNI (the Organisation for Medical Networked Information), a medical internet access service, based at Nottingham University.

The service's research began because of the large number of written and telephonecontacts that it was receiving, when email would have been quicker and more convenient.

The survey's author, John Kirriemuir, an information scientist and the service manager of OMNI, circulated questionnaires electronically and in the post …
VIBRIOS FROM THE INTESTINAL TRACT OF THE GRAY RAT
Authors: F. S. Jones, Ralph B. Little, Marion Orcutt
Journal: The Journal of Experimental Medicine (1932)

Vibrios obtained from the intestinal tracts of wild rats are described. The organism is a normal inhabitant of the lower ileum and cecum of the rat and may be cultivated from these regions. While these rat organisms are in their growth characters and morphology like those found in an intestinal disease of cattle they differ serologically from the cow organisms.
Progress in the application of DNA microarrays.
Authors: E K Lobenhofer, P R Bushel, C A Afshari, H K Hamadeh
Journal: Environmental Health Perspectives (2001)

Microarray technology has been applied to a variety of different fields to address fundamental research questions. The use of microarrays, or DNA chips, to study the gene expression profiles of biologic samples began in 1995. Since that time, the fundamental concepts behind the chip, the technology required for making and using these chips, and the multitude of statistical tools for analyzing the data have been extensively reviewed. For this reason, the focus of this review will be not on the technology itself but on the application of microarrays as a research tool and the future challenges of the field.
In search of an optimum dose escalation for narrowband UVB phototherapy: Is it time to quit 20% increments?
Authors: Gonca Boztepe, Hande Akıncı, Sedef Şahin, Aysen Karaduman, Sibel Ersoy Evans, Gül Erkin, Nilgün Atakan, Tülin Akan, Fikret Kölemen
Journal: Journal of the American Academy of Dermatology (2006)
Purified interferon as protection against rhinovirus infection.
Authors: G M Scott, R J Phillpotts, J Wallace, D S Secher, K Cantell, D A Tyrrell
Journal: BMJ (1982)

In a double-blind placebo-controlled study a preparation of human leucocyte interferon purified by affinity chromatography using a monoclonal antibody and applied by repeated nasal sprays reduced the incidence and severity of colds in volunteers challenged with human rhinovirus 9. Although interferon itself caused some symptoms, these were minor compared with the clinical colds. Interferon activity was still detectable in nasal washings as long as 26 hours after the last dose in about half the volunteers on active treatment.
Stimulation of Mouse and Human Primitive Hematopoiesis by Murine Embryonic Aorta-Gonad-Mesonephros–Derived Stromal Cell Lines
Authors: Ming-jiang Xu, Kohichiro Tsuji, Takahiro Ueda, Yoh-suke Mukouyama, Takahiko Hara, Feng-Chun Yang, Yasuhiro Ebihara, Sahoko Matsuoka, Atsushi Manabe, Akira Kikuchi, Mamoru Ito, Atsushi Miyajima, Tatsutoshi Nakahata
Journal: Blood (1998)
571 THE USEFULNESS OF GADOXETIC ACID (GD-EOB-DTPA)-ENHANCED MRI FOR THE QUANTITATIVE EVALUATION OF SMALL FOCAL LIVER LESIONS IN PATIENTS WITH CIRRHOSIS
Authors: Y. Matsumoto, M. Kitamoto, A. Igawa, R. Hayashi, H. Yamada, H. Okazaki, H. Nakahara, T. Itamoto
Journal: Journal of Hepatology (2010)
Characterization of Reentrant Circuits in Left Atrial Macroreentrant Tachycardia
Authors: Feifan Ouyang, Sabine Ernst, Thomas Vogtmann, Masahiko Goya, Marius Volkmer, Anselm Schaumann, Dietmar Bänsch, Matthias Antz, Karl-Heinz Kuck
Journal: Circulation (2002)

Background — Left atrial macroreentrant tachycardia (LAMRT) has not been characterized in detail. Methods and Results — Twenty-eight patients with LAMRT, including 4 patients with ablated typical atrial flutter (AFL), underwent electroanatomic mapping of the left atrium (LA) between February 1999 and October 2001. LA maps were performed during LAMRT in 26 patients and during sinus rhythm in 2 patients. Electrically silent areas or continuous lines of double potentials were identified as acquired anatomic barriers in all patients. In 23 of 26 patients with LAMRT mapping, 42 reentry circuits with a protected isthmus were identified. The isthmus was 11.8±5.9 mm wide, with the maximal amplitude of 0.07 to 3.61 mV. Radiofrequency pulses terminated all LAMRTs in 23 patients and resulted in conduction block across the isthmus in 20 patients. In 2 patients with sinus mapping, all identified isthmuses were ablated. Additionally, AFL was induced and ablated in 6 patients. Atrial tachycardia recurred in 4 patients: 3 patients without validated block across the isthmus presented with recurrence of the same LAMRT, and 1 patient without ablated cavotricuspid isthmus presented with AFL. All tachycardias were abolished during a second procedure. Of 25 patients with identified isthmuses, 20 patients were without atrial arrhythmia and 5 had only atrial fibrillation during a median follow-up of 14 months. Conclusion — The reentry circuit with a protected isthmus can be identified in 89% patients with LAMRT by electroanatomic mapping. The isthmuses were amenable to radiofrequency applications in most patients. No atrial tachycardia recurred in any patients with isthmus block.
A Call for Higher Standards for Breast Implants
Authors: David A. Kessler
Journal: JAMA (1993)

THE COUNCIL on Scientific Affairs report on silicone gel breast implants, adopted by the AMA House of Delegates and published in this issue ofThe Journal,<sup>1</sup>represents a missed opportunity. The Council encourages physicians to become fully informed about the current scientific data on these implants, but this report fails to provide a comprehensive safety review or a balanced discussion of the issues. The Council faults others for the controversies associated with these devices today, but it overlooks the serious failings of physicians and never articulates their responsibility with regard to the safety of medical devices. The Council makes policy recommendations that ignore the FDA's statutory authority and public health responsibilities and minimize the uncertainties and concerns that continue to surround these devices. The Council report states that it reflects the scientific literature as of December 1992. However, since then, other important studies have been published. Recent animal studies
Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation
Authors: Andrea Hoelbl, Boris Kovacic, Marc A. Kerenyi, Olivia Simma, Wolfgang Warsch, Yongzhi Cui, Hartmut Beug, Lothar Hennighausen, Richard Moriggl, Veronika Sexl
Journal: Blood (2006)
Red blood cell fragility in multiple sclerosis.
Authors: E. A. Caspary, F. Sewell, E. J. Field
Journal: BMJ (1967)

The work of Hellem (1960) and of Gaarder, Jonsen, Laland, Hellem, and Owren (1961) has made it clear that red blood cells are a potent source of adenosine diphosphate of consider able importance in determining the adhesiveness of platelets in vitro. Caspary (1965) showed that the presence of even 2% haematocrit red cells was enough to confer a normal degree of stickiness on platelets suspended in plasma. The implication of this finding, brought out in correspondence which followed the publication of the latter paper (Caspary, 1966), is that platelet stickiness might depend in some measure on the readi ness with which erythrocytes yield adenosine diphosphate, and a similar suggestion has more recently been made by Harrison and Mitchell (1966) and Hampton and Mitchell (1966). Atten tion had been drawn to abnormality in size of red blood cells in multiple sclerosis by Plum and Fog (1959), and the present work indicates that they are also more osmotically fragile.
PMO-110 An audit of pancreatic cancer outcomes in the district general hospital setting: outcomes appear better than national average
Authors: T Akbar, F Murphy
Journal: Gut (2012)

<h3>Introduction</h3> Pancreatic cancer outcomes nationally demonstrate poor survival outcomes with 1 and 3-month survival rates of 73% and 47%. We performed an audit of our experience of our patients with pancreatic cancer in the setting of a district general hospital and compared our results with the national dataset. <h3>Methods</h3> We carried out data search from our system with all patients with a new diagnosis over 16 months from June 2010 to October 2011. The information was correlated with case notes and relevant histology and radiology reports. The data were collected and entered on an Excel spreadsheet for analysis. <h3>Results</h3> 21 new diagnoses with a mean age of 73, range from 56 to 95. The male to female ratio was 3:2. The most common presenting symptoms were jaundice and abdominal pain. The average duration of symptoms developing to being seen was approximately 70 days. Patients on average had a CT scan within 7 days of being seen in clinic. Range 1–29 days. The most common radiological diagnosis was head of the pancreas tumour; representing 52% of cases. 62% of patients had biliary obstruction of which 69% had an ERCP and 31% had PTC insertion of a stent. The stent was changed at least once in 38% of these patients. 14% of patients had duodenal obstruction. 19% of patients underwent Whipples procedure with 57% patients having chemotherapy. Gemcitabine/Cisplatin combination was most commonly used. 48% of patients had died with a mean of 154 days from when they were first seen. The range was 80–226 days. 75% of the patients who had Whipples procedure and post op chemotherapy had metastatic disease on CT on average 10 months later. Of those that are still alive, only one other than those that had the Whipples procedure had survived more than a year. <h3>Conclusion</h3> Our data demonstrated that our outcomes were better than the national data set produced by the Pancreatic Cancer UK charity. The average 1-year survival is 16% and our figures show that 24% of our patients survived more than 1-year. Our cumulative survival at 1-month and three months was comparable to the national average (100% and 86% vs 74% and 47%), are patients have radiological diagnosis sooner and more of our patients go on to have surgery. Our survival data supports that as a district general hospital we are able to manage patients9 pancreatic cancer effectively and safely with good outcomes. <h3>Competing interests</h3> None declared.
Psychiatrist is suspended for three months for plagiarism
Authors: Owen Dyer
Journal: BMJ (2008)

The psychiatrist and media figure Raj Persaud has been suspended from practice for three months after a General Medical Council disciplinary panel found that he had brought the profession into disrepute with repeated acts of plagiarism.

Dr Persaud, who became famous through regular television appearances on ITV’s This Morning with Richard and Judy in the 1990s and later presented BBC Radio 4’s All in the Mind programme, admitted at the outset of his hearing that he had copied the words of several academics and authors in newspaper and journal articles and in his 2003 book From the Edge of the Couch .

Dr Persaud denied dishonesty, however, telling the GMC panel: “At the time, given the stress I was under, given …
Patients with Acute Urticaria/Angioedema to Nsaids Do Not Evolve to Chronic Urticaria
Authors: Inmaculada Doña, Carmen Rondon, Paloma Campo, Maria J. Torres, Natalia Blanca-López, Francisca Gomez, Maria Salas, Maria Dolores Ruiz, Gabriela Canto, Miguel Blanca
Journal: Journal of Allergy and Clinical Immunology (2013)
GW25-e3084 Clinical Outcomes within 25-month Follow-up in Patients with Type 2 Diabetes Mellitus after Elective Percutaneous Coronary Intervention: Effect of Albuminuria
Authors: Yang Jun-Qing, Peng Ran, Ji-Yan Chen, Ying-Ling Zhou, Wen-Hui Huang, Shuo Sun, De-Mou Luo, Li-Wen Li, Ning Tan, Jian-Fang Luo, Dan-Qing Yu, Hong Tan, Guang Li, Guang Li, Ji-Yan Chen
Journal: Journal of the American College of Cardiology (2014)
Obstructive Jaundice Caused by Postsurgical Granuloma of the Common Bile Duct
Authors: I. Farkas, A. Patkó, M. Kövári
Journal: Endoscopy (1980)

The bile duct can be visualized by injecting contrast material directly into the biliary system. The authors describe three cases of inflammatory, postsurgical granuloma in the vicinity of the cystic stump that gave rise to obstructive jaundice and the symptoms of choledocholithiasis, following bile duct operation. For diagnosis, endoscopic retrograde cholangio-pancreatography (ERCP) and percutaneous transhepatic cholangiography (PTC) were used. The importance of this change, the diagnosis, differential diagnosis and treatment are discussed.
Protective Effect of 4-(3,7,11,15-Tetramethyl-6,10,14-Hexadecatrienoyl)Morpholine on Liver Injury Induced by Hepatotoxins in Rats
Authors: Kenji Fujiwara, Yasuhiko Ohta, Itsuro Ogata, Yuzuru Sato, Yuji Oka, Shigeki Hayashi, Katsuyoshi Takatsuki, Hiroshi Oka
Journal: Hepatology (1984)

The effect of 4-(3,7,11,15-tetramethyl-6,10,14-hexadecatrienoyl)morpholine (E-0712), a new synthetic compound, on liver injury induced by two hepatotoxins in rats was studied. Oral doses of E-0712 four times at 0, 6, 12 and 18 hr significantly attenuated elevated SGPT values and prolonged prothrombin time (PT) at 24, 36, 48, 60 and 72 hr in rats with a single s.c. dose of D-galactosamine in which SGPT values and PT reached the peak within 48 hr. In cases in which a dose of carbon tetrachloride (i.p.) produced peak SGPT values and PT within 36 hr attenuation occurred likewise at 24, 36 and 60 hr. In the control and E-0712-treated rats dosed with D-galactosamine or carbon tetrachloride, SGPT values were positively correlated with PT at 24 hr. In addition, morphological degrees of acidophilic body formation or centrizonal necrosis were significantly reduced by E-0712. These results suggest that E-0712 protects against liver injury, particularly hepatocellular necrosis, induced by D-galactosamine and carbon tetrachloride in rats.
Unclaimed Bodies at the Anatomy Table
Authors: N. Dasgupta
Journal: JAMA (2004)

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A SIMPLE, ACCURATE AND RAPID METHOD OF LOCALIZING FOREIGN BODIES IN THE ORBIT.
Authors: VARD H. HULEN
Journal: JAMA (1904)

When the eye has been injured and there is a possibility that a foreign body remains, the very first procedure is to determine, if possible, the exact location of the object in reference to the eye. If the foreign body can not be seen with the ophthalmoscope we must resort to the<i>x</i>-ray, and should the result of such examination be positive, we then proceed to localization before any means whatsoever are tried for its removal. As the vast majority of the foreign bodies in eye cases (iron, steel, copper, lead, glass, etc.) are revealed by the Roentgen ray, we can usually be certain of a positive result if the foreign body be present. The circumstances attending the injury often determine the probable substance of the foreign matter present. Fortunately most of such injuries to the eye are produced by pieces of iron or steel, and as these objects are
Telemedicine: Where It Is and Where It's Going
Authors: Jim Grigsby
Journal: Annals of Internal Medicine (1998)

The term telemedicine encompasses a wide range of telecommunications and information technologies and many clinical applications, although interactive video may be the most common medium.The first telemedicine programs were established almost 40 years ago, but the technology has grown considerably in the past decade. Despite the expansion of telemedicine, the volume of patients receiving services that use the technology remains relatively low (about 21 000 in 1996). In part, this reflects the lack of a consistent coverage and payment policy and concerns about licensure, liability, and other issues. A considerable amount of federal funding has supported telemedicine in recent years, and legislators and federal, regional, and state policymakers are struggling with several crucial policy matters. Research on the effectiveness of telemedicine is somewhat limited, although the work that has been done thus far supports the hypothesis that, in general, the technology is medically effective. The cost-effectiveness of specific telemedicine applications has not yet been rigorously demonstrated.