tbuckley/cabot-search huggingface dataset:
History of Telemedicine: Evolution, Context, and Transformation
Authors: Stanley W. Borg
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
pH-triggered release of manganese from MnAu nanoparticles that enables cellular neuronal differentiation without cellular toxicity
Authors: Suk Ho Bhang, Jin Han, Hyeon-Ki Jang, Myung-Kyung Noh, Wan-Geun La, Minyoung Yi, Woo-Sik Kim, Yunhee Kim Kwon, Taekyung Yu, Byung-Soo Kim
Journal: Biomaterials (2015)
Pathological Correlates of Late Drug-Eluting Stent Thrombosis
Authors: Aloke V. Finn, Michael Joner, Gaku Nakazawa, Frank Kolodgie, John Newell, Mike C. John, Herman K. Gold, Renu Virmani
Journal: Circulation (2007)

Background— Late stent thrombosis (LST) after Cypher and Taxus drug-eluting stent placement has emerged as a major concern. Although the clinical predictors of LST have been reported, specific morphological and histological correlates of LST remain unknown. Methods and Results— From a registry totaling 81 human autopsies of drug-eluting stents, 46 (62 lesions) had a drug-eluting stent implanted &gt;30 days. We identified 28 lesions with thrombus and compared those with 34 of similar duration without thrombosis using computer-guided morphometric and histological analyses. LST was defined as an acute thrombus within a coronary artery stent in place &gt;30 days. Multiple logistic generalized estimating equations modeling demonstrated that endothelialization was the best predictor of thrombosis. The morphometric parameter that best correlated with endothelialization was the ratio of uncovered to total stent struts per section. A univariable logistic generalized estimating equations model of occurrence of thrombus in a stent section versus ratio of uncovered to total stent struts per section demonstrated a marked increase in risk for LST as the number of uncovered struts increased. The odds ratio for thrombus in a stent with a ratio of uncovered to total stent struts per section &gt;30% is 9.0 (95% CI, 3.5 to 22). Conclusions— The most powerful histological predictor of stent thrombosis was endothelial coverage. The best morphometric predictor of LST was the ratio of uncovered to total stent struts. Heterogeneity of healing is a common finding in drug-eluting stents with evidence of LST and demonstrates the importance of incomplete healing of the stented segment in the pathophysiology of LST.
Impact of Smoking on Oncologic Outcomes of Upper Tract Urothelial Carcinoma After Radical Nephroureterectomy
Authors: Michael Rink, Evanguelos Xylinas, Vitaly Margulis, Eugene K. Cha, Behfar Ehdaie, Jay D. Raman, Felix K. Chun, Kazumasa Matsumoto, Yair Lotan, Helena Furberg, Marek Babjuk, Armin Pycha, Christopher G. Wood, Pierre I. Karakiewicz, Margit Fisch, Douglas S. Scherr, Shahrokh F. Shariat
Journal: European Urology (2012)
The Diagnosticotherapeutic Procedure
Authors: Stanley N. Schwartz
Journal: Annals of Internal Medicine (1988)

Ad Libitum1 November 1988The Diagnosticotherapeutic ProcedureStanley N. Schwartz, MDStanley N. Schwartz, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-9-764_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDo you ever really read operative notes? I read them all the time. My favorites are those huge, three-page notes written in one endless paragraph. My surgical friends will describe every move of the hands during a 6-hour operation. Sometimes I wonder how they can remember such minutiae when I have trouble recalling particulars of a patient visit 15 minutes earlier.We non-proceduralists (cognitive physicians, non-invasive physicians) concern ourselves with what we see and what we do. Rarely do we pay much attention to the mechanics of an office visit. Surgeons, on the other hand, document how they treat a... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Tulsa, Oklahoma PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1988Volume 109, Issue 9Page: 764-765KeywordsSurgeons ePublished: 1 December 2008 Issue Published: 1 November 1988 Copyright & Permissions©1988 American College of PhysiciansPDF downloadLoading ...
Factors Affecting the Educational Diagnosis of Diabetic Patients
Authors: Wayne K Davis, Alan L Hull, Michele L Boutaugh
Journal: Diabetes Care (1981)

An accurate determination of the educational needs of diabetic patients is based on a wide range of patient characteristics. In the development of an assessment instrument to determine the educational needs of patients, the relative importance of numerous patient characteristics was determined. A questionnaire was mailed to 1518 health professionals who are either members of the American Association of Diabetes Educators or community health nurses in the state of Michigan. Analyses of the responses to this questionnaire have provided information regarding the knowledge, psychosocial, and demographic characteristics of patients, which are thought to be important in an educational diagnosis. Questions to measure these identified characteristics will be incorporated into an instrument that will assess the educational needs of diabetic patients.
Combined modulation of polycomb and trithorax genes rejuvenates Î² cell replication
Authors: Josie X. Zhou, Sangeeta Dhawan, Hualin Fu, Emily Snyder, Rita Bottino, Sharmistha Kundu, Seung K. Kim, Anil Bhushan
Journal: Journal of Clinical Investigation (2013)

Inadequate functional β cell mass underlies both type 1 and type 2 diabetes. β Cell growth and regeneration also decrease with age through mechanisms that are not fully understood. Age-dependent loss of enhancer of zeste homolog 2 (EZH2) prevents adult β cell replication through derepression of the gene encoding cyclin-dependent kinase inhibitor 2a (INK4a). We investigated whether replenishing EZH2 could reverse the age-dependent increase of Ink4a transcription. We generated an inducible pancreatic β cell-specific Ezh2 transgenic mouse model and showed that transgene expression of Ezh2 was sufficient to increase β cell replication and regeneration in young adult mice. In mice older than 8 months, induction of Ezh2 was unable to repress Ink4a. Older mice had an enrichment of a trithorax group (TrxG) protein complex at the Ink4a locus. Knockdown of TrxG complex components, in conjunction with expression of Ezh2, resulted in Ink4a repression and increased replication of β cells in aged mice. These results indicate that combined modulation of polycomb group proteins, such as EZH2, along with TrxG proteins to repress Ink4a can rejuvenate the replication capacity of aged β cells. This study provides potential therapeutic targets for expansion of adult β cell mass.
Electrocardiographic correlates of myocardial ischaemia induced by atrial and ventricular pacing in dogs with coronary stenosis
Authors: D. M MIRVIS
Journal: Cardiovascular Research (1985)

We determined the electrocardiographic response to pacing-induced tachycardia in 45 dogs. Pacing was performed using left atrial, left atrial-right ventricular sequential or left atrial-left ventricular sequential modes at rates of 90 to 250 beats X min-1. Body surface isopotential maps in 15 dogs with normal coronary circulations defined the normal response to rate; surface potential extrema during the S-T segment increased in strength with increasing rate but spatial features remained constant. In the other 30 dogs, an ameroid constrictor was placed around the left circumflex coronary artery. Two weeks after implantation, atrial pacing to rates of 190 beats X min-1 or greater resulted in flat, S-T segment depression, with new and abnormal negative voltages registered over the inferior and left posterior torso. However, with either form of ventricular pacing, tachycardia with coronary obstruction did not alter the S-T segment response seen in control animals, in either intensity or spatial parameters. We interpret these findings to suggest that: in normal dogs, tachycardia produced a common electrocardiographic effect regardless of activation pattern; and tachycardia in the presence of coronary constriction results in subendocardial myocardial ischaemia that, with atrial pacing, reverses the normal transmural S-T segment potential gradient and causes body surface S-T segment depression, but with primary ventricular stimulation, the subendocardial ischaemia does not alter the transventricular repolarisation gradients sufficiently to generate body surface S-T segment shifts.
Survival in Systemic Lupus Erythematosus-Reply
Authors: Naomi F. Rothfield
Journal: JAMA (1978)

We agree that there are many improvements in diagnosis and therapy during the years that this study covered and mentioned specifically in the discussion: The notably improved survival rates we have observed may be due to several factors. One may be a generally better understanding of the disease and complications of therapy. Another may be the recent use of newer antibiotics. We do not believe we were diagnosing additional lupus cases because of the use of the antinuclear antibody, C3, or anti-DNA antibodies since all patients in both groups met the American Rheumatism Association's (ARA) Preliminary Criteria for the Diagnosis of SLE, which does not include any of these laboratory tests. Indeed, the lupus erythematosus cell test, which is included in the criteria, was positive in a higher percentage of the New York patients because this test was performed at every clinic visit in New York and was
Abstract A47: The LKB1-AMPK pathway mediates the metabolic stress response of dormant ovarian cancer spheroids
Authors: Teresa Peart, Elena Fazio, Yudith Ramos-Valdes, Monique Bertrand, Jacob McGee, Michel Prefontaine, Akira Sugimoto, Gabriel E. DiMattia, Trevor G. Shepherd
Journal: Clinical Cancer Research (2013)

Abstract Metastatic epithelial ovarian cancer (EOC) cells can form multicellular spheroids while in suspension and disperse throughout the peritoneum via ascites to seed secondary lesions. We hypothesize that EOC spheroids are key mediators of metastasis, which use specific signaling pathways to alter cell metabolism for increased survival. Our lab discovered that AKT signaling is reduced during spheroid formation leading to cellular quiescence and autophagy. Given the induction of quiescence and autophagy in EOC spheroids, we are studying the 5′-AMP-activated protein kinase (AMPK) pathway as a master controller of the metabolic stress response and dormant phenotype of EOC spheroids. We demonstrate AMPK activity and its upstream kinase LKB1 are increased in quiescent EOC spheroids compared with proliferating adherent EOC cells. We also show elevated AMPK activity in spheroids isolated directly from patient ascites. Targeted knockdown of STK11, encoding LKB1, reduces cell viability in ovarian cancer cell line spheroids; PRKAA1 (AMPKα1) knockdown has little to no effect on EOC cell or spheroid viability. Combination of STK11 knockdown with carboplatin treatment leads to a synergistic enhancement in EOC spheroid cell death. In contrast, AICAR treatment of proliferating adherent ovarian cancer cell lines and primary EOC cells induces AMPK activity and causes either cytostasis or cell death. In addition, AICAR treatment of spheroids during reattachment decreases the dispersion capacity of migrating EOC cells. These results offer a glimpse of the potential important contributions of LKB1-AMPK pathway in stress signaling related to EOC cell survival during metastasis. In addition, downstream effectors of upregulated LKB1-AMPK signalling may provide additional mechanisms by which EOC evades chemotherapy. It is foreseeable that these findings will allow us to identify new therapeutic targets within this pathway critical to EOC progression for ultimate translation to the clinic. Citation Format: Teresa Peart, Elena Fazio, Yudith Ramos-Valdes, Monique Bertrand, Jacob McGee, Michel Prefontaine, Akira Sugimoto, Gabriel E. DiMattia, Trevor G. Shepherd. The LKB1-AMPK pathway mediates the metabolic stress response of dormant ovarian cancer spheroids. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr A47.
CRETINISM AND MYXOEDEMA
Authors: H. Gardiner-Hill
Journal: BMJ (1937)

<h3>Abstract</h3> HIV viral load (VL) is an important predictor of HIV progression and transmission. Anti-retroviral therapy (ART) has been reported to reduce HIV transmission by lowering VL. However, apart from this beneficial effect, increased levels of population mean set-point viral load (SPVL), an estimator for HIV virulence, have been observed in men who have sex with men (MSM) in the decade following the introduction of ART in the Netherlands. Several studies have been devoted to explain these counter-intuitive trends in SPVL. However, to our knowledge, none of these studies has investigated an explanation in which it arises as the result of a sexually transmitted infection (STI) co-factor in detail. In this study, we adapted an event-based, individual-based model to investigate how STI co-infection and sexual risk behaviour affect the evolution of HIV SPVL in MSM before and after the introduction of ART. The results suggest that sexual risk behaviour has an effect on SPVL and indicate that more data are needed to test the effect of STI co-factors on SPVL. Furthermore, the observed trends in SPVL cannot be explained by sexual risk behaviour and STI co-factors only. We recommend to develop mathematical models including also factors related to viral evolution as reported earlier in the literature. However, this requires more complex models, and the collection of more data for parameter estimation than what is currently available.
Clinical Aspects of Postirradiation Sarcomas1
Authors: E. Robinson, A. I. Neugut, P. Wylie
Journal: JNCI Journal of the National Cancer Institute (1988)

The number of cancer patients who live longer and are cured of their disease is incereasung.Many of them have recevid radiotherapy as part of ther treatment. postirradion sarcoma(PIS), while still uncommon, is a complication which is appearing more frequently as the number of long-term survivors increases. studies of the clinical characteristies of PIS, such as stage of disease, grade, survival, and prognosis, are there fore of increasing importance, and may lead to different strategies for early detection and preventaion. in a literature review of PIS, we identified 344 case with sufficient data for analysis of these clinical characteristics. in these selected cases, we found that: (a) PIS was most often diagnosed at an advanced stage and high grade;(b) most of the turnos were location in arease where radical surgey could not be performed;(c) the responce rate to chemotheapy was almost always poor; and (d) most partient which PIS dled from locally advanced and/or metastaic disease within a few months after diagnosis.PIS is a serious, usually fatal, late complication of radiotherrapy and it should be weighed in the decision to use this modality of therapy in the follow up of cance partients a low theshold of suspication for PIS is recommended in order to detect it early for possible resection.Because of the poor pronosis more aggressive and investingative chemotherra peutic regimens are warraned. [J Natl Caner Inst 1988;80:233–240]
Costs that would be incurred in establishing "difficult airway register" could be better spent
Authors: E. Morris, A. Osborne, C. Jewkes
Journal: BMJ (1996)

EDITOR,—J B Liban proposes that a national “difficult airway register” should be established to identify and store information on those patients in whom airway management has been problematic.1 Several points should be considered before such a scheme is proceeded with.

Liban states that “about 41% of all deaths attributable to anaesthesia are related to difficulties with endotracheal intubation.” These data, from the confidential inquiries into maternal deaths, refer only to …
Wall thickness, cavity dimensions, and myocardial contractility of the left ventricle in patients with simple transposition of the great arteries. A multicenter study of patients from 10 to 20 years of age.
Authors: A M Carceller, J C Fouron, J F Smallhorn, J L Cloez, N H van Doesburg, P Mauran, G Ducharme, C Pernot, A Davignon
Journal: Circulation (1986)

Fifty-one patients with uncomplicated transposition of the great arteries (TGA) and normal pulmonary pressure who were 10 to 20 years old and 69 normal subjects matched for age were studied by M mode echocardiography. Left ventricular internal dimensions and posterior wall thickness showed positive correlation with the body surface area in the TGA as well as in the control groups. Values for these parameters in the TGA group were generally smaller than those in the normal population. Septal thickness of patients with TGA (5.9 +/- 1 mm) was also smaller than that in the control group (6.6 +/- 1 mm) (p less than .01). Septal motion was normal in 11 patients with TGA and paradoxical in 19 patients in this group. In the other 21 patients the septum was flat. The following systolic time intervals of the left ventricle were found for patients with TGA: preejection period (PEP) 64 +/- 11 msec, ejection time (ET) 310 +/- 37 msec, and PEP/ET 0.21 +/- 0.04. These values were significantly different from those of the right ventricle for the normal population: PEP 77 +/- 12 (p less than .01), ET 327 +/- 25 (p less than .05), and PEP/ET 0.24 +/- 0.03 (p less than .01). Shortening fraction and mean velocity of circumferential fiber shortening (49 +/- 7% and 1.6 +/- 0.3 circ/sec, respectively) were also significantly higher (p less than .01) in patients with TGA than in the control group (33 +/- 4% and 1.1 +/- 0.2 circ/sec). These data should help achieve reliable quantitative and qualitative interpretations of echocardiograms of patients with TGA.
B3-01: A randomized Phase III study to compare the overall survival of gefitinib (IRESSA) versus docetaxel in Japanese patients with previously treated advanced non-small-cell lung cancer
Authors: Ikuo Sekine, Yukito Ichinose, Yutaka Nishiwaki, Nobuyuki Yamamoto, Masahiro Tsuboi, Kazuhiko Nakagawa, Tetsu Shinkai, Haiyi Jiang, Tomohide Tamura, Masahiro Fukuoka
Journal: Journal of Thoracic Oncology (2007)
Platypnea (Diffuse Zone I Phenomenon?)
Authors: Michael Altman, Eugene D. Robin
Journal: New England Journal of Medicine (1969)

ORTHOPNEA, increased dyspnea in the recumbent position relieved by sitting, is a common and important symptom of congestive heart failure. This report describes a patient with severe obstructive emphysema in whom striking and severe dyspnea developed in the upright position. This dyspnea was relieved when he assumed a supine or prone position. By analogy, this symptom has been called "platypnea" — dyspnea produced by assumption of an erect position and relieved by a recumbent one.Case ReportE.R. (P3–54–00), a 59-year-old Welshman, was admitted to the Presbyterian—University Hospital, Pittsburgh, in September, 1964. He had an 8-year history of progressive dyspnea, . . .
NHS Executive will not give single definition of hours of work Debate opens on accountability in the NHS Reductions in defence medical services causes BMA concern BMA will join managers in top level talks Labour party accuses government of privatisation by stealth
Authors: L. Beecham
Journal: BMJ (1995)

# NHS Executive will not give single definition of hours of work {#article-title-2}

NHS Executive will not give single definition of hours of work The NHS Executive has decided that a single definition of junior doctors' hours of work would be too narrow and restrictive. But in his latest letter to health authorities, NHS trusts, and regional task forces on implementing the new deal the executive's medical director, Dr Graham Winyard, says that in broad terms “doctors on duty are at work when they are not resting. For example, a doctor contracted for a 72 hours on call rota must have 16 hours of rest in order to meet the target of an average of 56 hours work a week.”

The letter sets out in detail the action that should be taken to ensure full implementation of the new deal “at the earliest possible date.” Dr Winyard says that where work is too high for an on call rota—for example, when out of hours calls are so frequent that reasonable periods of uninterrupted rest cannot be secured—efforts should be concentrated on moving junior doctors to a partial or full shift system. The new monitoring arrangements, which were announced at the end of 1994, should ensure that nationally and regionally there was an accurate and consistent picture of the working lives of junior doctors. Dr Winyard emphasises that junior doctors must be directly involved in developing monitoring systems, collecting data, and validating results.

To improve the monitoring arrangements task forces have been asked to collect data on the comparative performance of units. This will be made available to purchasers and may …
Activated Gα13 Impairs Cell Invasiveness through p190RhoGAP-Mediated Inhibition of RhoA Activity
Authors: Rubén A. Bartolomé, Natalia Wright, Isabel Molina-Ortiz, Francisco J. Sánchez-Luque, Joaquin Teixidó
Journal: Cancer Research (2008)

Abstract The GTPase RhoA is a downstream target of heterotrimeric G13 proteins and plays key roles in cell migration and invasion. Here, we show that expression in human melanoma cells of a constitutively active, GTPase-deficient Gα13 form (Gα13QL) or lysophosphatidylcholine (LPC)-promoted signaling through Gα13-coupled receptors led to a blockade of chemokine-stimulated RhoA activation and cell invasion that was rescued by active RhoA. Melanoma cells expressing Gα13QL or cells stimulated with LPC displayed an increase in p190RhoGAP activation, and defects in RhoA activation and invasion were recovered by knocking down p190RhoGAP expression, thus identifying this GTPase-activating protein (GAP) protein as a downstream Gα13 target that is responsible for these inhibitory responses. In addition, defective stress fiber assembly and reduced migration speed underlay inefficient invasion of Gα13QL melanoma cells. Importantly, Gα13QL expression in melanoma cells led to impairment in lung metastasis associated with prolonged survival in SCID mice. The data indicate that Gα13-dependent downstream effects on RhoA activation and invasion tightly depend on cell type–specific GAP activities and that Gα13-p190RhoGAP signaling might represent a potential target for intervention in melanoma metastasis. [Cancer Res 2008;68(20):8221–30]