tbuckley/cabot-search huggingface dataset:
Risk of Cancer Mortality in Populations Living Near Nuclear Facilities
Authors: Geoffrey R. Howe
Journal: JAMA (1991)

Studies of populations exposed to high levels of ionizing radiation, such as the survivors of the atomic bombings at Hiroshima and Nagasaki<sup>1</sup>and tuberculosis patients exposed to multiple chest fluoroscopies,<sup>2</sup>have clearly demonstrated that such exposures increase the risk of a number of cancers. This basic observation has inevitably raised public concern as to whether the normal operation of nuclear power facilities presents an increased risk of cancer to those who work in such facilities, or who are residents near them. This concern has been heightened by recent studies from the United Kingdom that have reported excess incidence of childhood leukemia in children living near several nuclear facilities, most notably a fuel reprocessing plant located at Sellafield in northwest England.<sup>3</sup> To estimate the cancer risks associated with exposure to low doses of radiation, the usual procedure is to extrapolate the results of high-dose studies, such as that
Rare Adverse Effect of Treatment With Minocycline
Authors: Ashika Odhav, Chirag Odhav, Nimesh A. Dayal
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Geoffrey Christopher Irvine
Authors: S. A. Murray, M. McNeil
Journal: BMJ (2010)

After graduating in Edinburgh and working there for two years, Geoffrey Christopher Irvine (“Geoff”) returned to Kenya, where he had been born, and worked in Kikuyu and Tumutumu Hospitals before succeeding his father as medical superintendent of the Presbyterian Church of East Africa Chogoria Hospital. His visionary leadership took an already excellent rural hospital, which had been founded and then developed over 30 years by his father, Dr Clive Irvine, to a new level of comprehensive health care for the community.

TB and leprosy control programmes were started in remote rural areas, with donor financing. Well ahead of his time, Geoff visualised integrated curative and preventive primary health programmes, which resulted in dramatic improvements in child and maternal health. A network of 30 clinics was established, each supported by a local health committee, offering daily curative …
The cytoskeleton and its importance as a mediator of inflammation.
Authors: K R Rogers, C J Morris, D R Blake
Journal: Annals of the Rheumatic Diseases (1992)

Cellular life by its very nature requires organi- sation and structure.Cells must, however, also have a degree of plasticity to perform varying cellular functions.The cytoskeleton possesses the required characteristics for both these properties.The eukaryotic cytoskeleton is a complex three dimensional lattice radiating throughout the cytosol and nucleus which is made up of three distinct types of filament' (table 1).There is, however, a vast array of other associated proteins, many ofwhich have unknown function.The protein composition of the cytoskeleton is characteristic for a specific cell or tissue type, and provides the machinery required for cellular/tissue function.Within the cytosol these filaments provide a structural and an organising role.Many organelles, for example, have a close association with the various filament types.These include the mitochondria, Research UnitGolgi apparatus, and endoplasmic reticulum.25-29 Ashfield Street, An intact cytoskeleton is essential for vital London El 2AD, cellular functions, including vesicle/
III. The Support of House Officer Training Programs
Authors: Richard H. Lyons
Journal: JAMA (1961)

BEFORE accepting this assignment, I asked myself why a chairman of a department of medicine could presume to speak as an attending staff member. However, I suspect some of the members of the program committee realized that over a 12-year period we have established in Syracuse a system of medical student and house officer instruction which now incorporates all of the private patients of all of the practicing members of the department of medicine. The program is conducted to a very large extent in much the same way as it might be conducted on service patients; and I am happy to report that in our community, the town and gown do not live in an atmosphere of mutual coexistence, but rather in an atmosphere of trust and progressive cooperative development due to the fine traditions maintained by Dr. Weiskotten. Because of this spirit of cooperation I believe that I can
Standard and Computed Tomography in the Evaluation of Chest Neoplasms
Authors: Ferris M. Hall, Morris Simon, Robert D. Pugatch
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 January 1988Standard and Computed Tomography in the Evaluation of Chest NeoplasmsFERRIS M. HALL, M.D., MORRIS SIMON, M.D., ROBERT D. PUGATCH, M.D.FERRIS M. HALL, M.D.Search for more papers by this author, MORRIS SIMON, M.D.Search for more papers by this author, ROBERT D. PUGATCH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-1-160_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Inouye and Sox (1) conclude that "This study confirms a role for standard (conventional) tomography in the evaluation of chest neoplasms. On the basis of its lower cost, standard tomography is recommended for the evaluation of regional spread of non-small-cell lung cancer in the subgroups of patients with low pretest probability of mediastinal metastases, high pretest probability of mediastinal metastases, or low pretest probability of ipsilateral hilar metastases . . . The recommendations derived from this study are based on extensive review and detailed analysis of the literature."We find it inconceivable that these conclusions could be...Reference1. INOUYESOX SH. Standard and computed tomography in the evaluation of neoplasms of the chest: a comparative efficacy assessment. Ann Intern Med. 1986;105:906-24. LinkGoogle Scholar1. FLETCHERFLETCHERWAGNER RSE. Clinical Epidemiology: the Essentials. Baltimore: Williams and Wilkins; 1982:148-9. Google Scholar2. BRADFORD A. Medical ethics and controlled trials. Br Med J. 1963;1:1043-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAcknowledgments in ArticlesTHERESA C. MCLOUD, M.D. 1 January 1988Volume 108, Issue 1Page: 160-160KeywordsComputed axial tomographyLung and intrathoracic tumorsThoraxTomography Issue Published: 1 January 1988 PDF downloadLoading ...
Predictors of postmenopausal osteoporosis: Study methods and analysis require clarification
Authors: J. Wong
Journal: BMJ (2003)

EDITOR—Hodson and Marsh say that ultra-sound may be a promising screening or diagnostic test for detecting osteoporosis.1 Clarification is necessary before their findings can be accepted. Their population, selected on the basis of perceived risk, has a higher risk (16%) than would normally be expected in primary care (4%).2 Interpretation of diagnostic data …
Abstract 3245: SRC-3: A prostate cancer oncogene with the same modus operandi in different niches
Authors: Jean Tien, Zhaoliang Liu, Lan Liao, Fen Wang, Jianming Xu
Journal: Cancer Research (2010)

Abstract Prostatic adenocarcinoma will affect one in six American men and represents the second leading cause of cancer death in this population. Tumors that are locally invasive/ metastatic at diagnosis cause the majority of prostate cancer deaths. SRC3 is a p160 family coactivator overexpressed in invasive prostate cancers. A recent study in our laboratory demonstrated it is also highly expressed in tumors of the TRAMP mouse, a cancer model in which an androgen-responsive probasin promoter drives expression of the SV40 viral oncogene in several prostate cell types. Global deletion of SRC3 in TRAMP mice arrested primary prostate tumors at the well-differentiated stage and eliminated metastasis. Transformation of prostatic luminal epithelial cells (LECs) into invasive cancers is a key feature of the TRAMP phenotype. Therefore, we hypothesized selective deletion of SRC3 in these cells would inhibit primary tumor growth and metastasis. To test the hypothesis, we crossed floxed SRC3/TRAMP mice with mice harboring a Cre recombinase gene driven by the LEC-specific probasin promoter. Efficacy of SRC3 knockout in SRC3c−/−/TRAMP mice was confirmed via immunohistochemistry and Western blotting. We compared prostate tumor size, composition and metastases in SRC3c−/−/TRAMP vs. WT/TRAMP mice at 12 (n=3/5), 18 (n=7/7), 24 (n=9/9) and 30 (n=6/6) weeks of age. We observed no statistically significant differences in prostate or GU tract weight at any time point, though a trend toward decreased tumor size in the knockout was evident at 30 weeks. Tumor composition differed between SRC3c−/−/TRAMP and WT/TRAMP mice at 24 and 30 weeks. While synaptophysin(+) (neuroendocrine) cells were virtually absent in dedifferentiated regions of WT/TRAMP prostate, large synaptophysin(+) cell clusters were visible in the majority of sections taken from prostates of in SRC3c−/−/TRAMP mice. Neuroendocrine cell clusters were positive for SRC3 and negative for AR. Interestingly, 24 and 30 week-old SRC3c−/−/TRAMP mice also had tumors of the liver, lung and kidney: common sites of neuroendocrine metastasis in the TRAMP model. Given that SRC3c−/−/TRAMP mice have primary tumors of equivalent size to WT/TRAMP but skewed toward neuroendocrine composition, SRC3 deletion in luminal epithelial cells appears to inhibit cancer growth in a cell autonomous fashion thus enabling neuroendocrine proliferation and metastasis. Since global SRC3−/−/TRAMP mice have no neuroendocrine tumors, our findings indicate SRC3 may also act as an oncogene in neuroendocrine cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3245.
Usefulness of SPECT/CT in the Diagnosis of Intrathoracic Goiter versus Metastases From Cancer of the Breast
Authors: Christine W. Dümcke, Jan L. Madsen
Journal: Clinical Nuclear Medicine (2007)

A 77-year-old woman was referred because of local reoccurrence of cancer of the breast. Chest x-ray showed a mediastinal tumor with dislocation of the trachea to the right. A Tc-99m pertechnetate scan showed irregular tracer uptake in an enlarged left lobe of the thyroid gland. Ultrasound confirmed the diagnosis of a nodular goiter with intrathoracic growth of the left lobe. A SPECT/CT scan of the mediastinum clearly showed that the soft tissue tumor was the left lobe of the thyroid gland, and not lymphatic metastases.
The Role of Nutrition Education in Combating Food Fads
Authors: William B. Bean
Journal: JAMA (1961)

The cynic looking today at the inordinate capacity of the American people for self-delusion might feel that Jefferson's ideas and ideals about education and enlightenment are the only salvation of man in a democracy that has fallen on evil days. If confronted with the alternative of widespread self-deceit or the incessant brain-washing propaganda of Big Brother, we may feel justified in condoning the silly in the knowledge that the less numerous intelligent members of society must make up for widespread ignorance. As an example of the hopeful attitude that education may really combat food fads and quackery we have this booklet. It consists of the major papers presented at a symposium on nutrition research and education held in Berkeley, Calif., Jan. 15, 1959, under the joint sponsorship of the Northern California Section, Institute of Food Technologists and The Nutrition Foundation, Inc. There is a remarkable degree of unanimity in discussions
Medical Consultation via Communications Satellite
Authors: Randall S. Riggs
Journal: JAMA (1974)

A patient with lymphosarcoma was described via communications earth satellite to medical experts in Washington, DC from aboard the hospital ship SS<i>Hope</i>anchored in Maceió, Brazil. The experimental consultation employed a small, potentially mobile transmitter-receiver aboard the ship to exchange voice and teletype communication, to receive facsimiles of journal articles, and to send still video pictures of patients, x-ray films, and microscopic slides. Medical telecommunications via satellite can provide prompt, expert medical consultation to remote areas of the globe and can increase the effectiveness of medical personnel. (<i>JAMA</i>228:600-602, 1974)
Pyloric atresia–junctional epidermolysis bullosa syndrome: mutations in the integrin β4 gene (ITGB4) in two unrelated patients with mild disease
Authors: None Mellerio, None Pulkkinen, None Mcmillan, None Lake, None Horn, None Tidman, None Harper, None Mcgrath, None Uitto, None Eady
Journal: British Journal of Dermatology (1998)

Junctional epidermolysis bullosa associated with pyloric atresia (EB-PA; OMIM 226730) is a rare autosomal recessively inherited disease in which mucocutaneous fragility is associated with gastrointestinal atresia. This disease is usually fatal within the first few weeks or months of life even following surgical correction of the intestinal obstruction. Recently, mutations in the genes encoding the epithelial integrin alpha6beta4 (ITGA6 and ITGB4) have been identified in several patients with EB-PA. We report two unrelated patients with this disease who have survived into early childhood with mild cutaneous involvement, in whom we have identified pathogenetic mutations in ITGB4. The first patient was a compound heterozygote for a splice site mutation in exon 30 (3793 + 1G-to-A) and a non-sense mutation in exon 36 (W1478X), and the second was a compound heterozygote for a missense mutation in exon 3 (C38R) and a 1 bp deletion in exon 36 (4776delG). Although the non-sense and deletion mutations are predicted to result in markedly reduced beta4 integrin mRNA levels, the presence of the missense or splice site mutation on the second allele may enable the synthesis of some functional, albeit perturbed, beta4 polypeptide. Determination of the molecular mechanisms in these two cases increases our understanding of EB-PA and may enable correlation between genotype and phenotype.
Panniculitis-like lesions in yersiniosis
Authors: G.L. WANTZIN, K. THOMSEN
Journal: British Journal of Dermatology (1982)

Infection with Yersinia enterocolitica usually produces gastrointestinal symptoms. We here report a severe case of panniculitis‐like lesions caused by Yersinia enterocolitica where only mild gastrointestinal symptoms were noticed. Blood samples revealed high Yersinia enterocolilica serotype 3 titres, increased ESR, leucocytosis, and in addition Yersinia enterocolitica was cultured from the faeces. When panniculitis‐like lesions are the only clinical manifestation yersiniosis should be considered as a possible cause.
Cetrimide allergy presenting as suspected non-accidental injury.
Authors: J K Inman
Journal: BMJ (1982)

Cetrimide allergy presenting as suspected non-accidental injurySuspected non-accidental injury is becoming a more frequent paediatric diagnosis in Britain.I describe a case of presumed non-accidental injury that proved to be an allergic response to cetrimide (12% solution), a commonly prescribed preparation.Case report
Dermatomyositis and Malignancy
Authors: BARBARA E. BARNES
Journal: Annals of Internal Medicine (1976)

Although there appears to be an increased incidence of malignancy among patients with dermatomyositis, demonstration of definitive statistical significance is precluded by the lack of large, controlled series. Patients with the two diseases tend to be older than the general dermatomyositis population and younger than those with cancer alone; and there is a preponderance of female patients. Tumors of the ovary and stomach are more frequently observed than in the general population, while colorectal malignancies are underrepresented. Most reported cases show development of the diseases within a year of one another, and, in some patients, the course of the myopathy follows that of the tumor. No definitive cause for the myopathy in these patients has been established.
The Physician and the Surgery Patient
Authors: Alfred Hurwitz
Journal: JAMA (1961)

<h3>To the Editor:—</h3> I congratulate Dr. Rardin,The Journal, Nov. 5, p. 1254, on the intimate and inspiring rapport that he has developed with his patients, but I must take violent exception to his relegation of the surgeon's role to that of a pair of hands. Any conscientious surgeon who has been trained to treat the total patient, and who has been imbued with the feeling that a surgeon who is too busy to talk to his patient and the family is too busy to practice surgery, must cry out in protest. If a family physician has to be responsible for the preoperative and postoperative care, to assure "that the patient comes to the operating room with an empty stomach," and to see that the "anesthesiologist has had a chance to gather and test all the equipment" it is high time for him to seek a more trustworthy team. The
LONG-TERM EFFICACY OF ENDOVASCULAR TREATMENT FOR PATIENTS WITH CRITICAL LIMB ISCHEMIA DUE TO ISOLATED BELOW THE KNEE LESIONS
Authors: Kiyonori Nanto, Osamu iida, Yoshimitsu Soga, Kenji Suzuki, Terutoshi Yamaoka, Nobuhiro Suematsu, Yusuke Miyashita, Junichi Tazaki
Journal: Journal of the American College of Cardiology (2012)
RBM24: a 'Regional Business Manager' in charge of the maintenance of sarcomeric protein expression 24 h a day?
Authors: E. Ehler
Journal: Cardiovascular Research (2012)

This editorial refers to ‘RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility’ by K.L. Poon et al., doi:10.1093/cvr/cvs095. 

RNA-binding proteins affect the proteome of a single cell by controlling alternative splicing, transport, localization, and stability of their target RNAs.1 They often display tissue-specific expression, and their crucial influence on the protein set-up especially in muscle cells has become recognized recently.2 A contribution by Poon et al. 3 focuses on RBM24 (also known as Seb-4) and its role in heart development. Their interest was sparked by the observation that Rbm24 is dramatically up-regulated in human embryonic stem cells upon differentiation into cardiomyocytes. They went on to characterize its expression pattern in zebrafish embryos, where its expression was mainly observed in the heart and somites. This fits well with previous data from another group on Xenopus embryos, who had shown a region-specific expression pattern of Rbm24 in the heart and the somites with minor levels in the lens and otic vesicles.4 A major part of the zebrafish genome is duplicated,5 and RMB24 also exists as two variants, Rbm24a and Rbm24b. Poon et al. focused their work on Rbm24a and were able to show that knockdown of its expression by morpholino oligonucleotides in zebrafish leads to impaired contractility of the heart.3 The supplementary data show no discernible effects on the somites, and the vasculature also seems to be normal in the morphants. The heart phenotype is explained by a reduced complexity of the myofibrillar meshwork in the embryonic cardiomyocytes, potentially due to a slight …
Daily modifications of splanchnic hemodynamics (SH) in cirrhotics with different degree of variceal bleeding (VB) risk
Authors: S SIRINGO
Journal: Hepatology (1995)

Alcohol induced liver disease or alcoholic liver disease (ALD), a complex trait, encompasses a gamut of pathophysiological alterations in the liver due to continuous exposure to a toxic amount of alcohol (more than 80 g per day). Of all chronic heavy drinkers, only 15–20% develops hepatitis or cirrhosis concomitantly or in succession. Several studies revealed that inter-individual as well as inter-ethnic genetic variation is one of the major factors that predispose to ALD. The role of genetic factors in ALD has long been sought for in ethnically distinct population groups. ALD is fast emerging as an important cause of chronic liver disease in India; even in populations such as “Bengalis” who were “culturally immune” earlier. While the genetic involvement in the pathogenesis of ALD is being sought for in different races, the complex pathophysiology of ALD as well as the knowledge of population level diversity of the relevant alcohol metabolizing and inflammatory pathways mandates the need for well designed studies of genetic factors in ethnically distinct population groups. An array of cytokines plays a critical role as mediators of injury, inflammation, fibrosis and cirrhosis in ALD. We, therefore, studied the association of polymorphisms in five relevant cytokine genes with “clinically significant” ALD in an ethnic “Bengali” population in Eastern India. Compared with “alcoholic” controls without liver disease (n = 110), TNFα −238AA genotype, IL1β −511CC genotype, TGFβ1 − 509CC genotype and IL10 −592AA genotype were significantly overrepresented in ALD patients (n = 181; OR = 2.4 and 95% CI 1.2–5.5, Pgenotype = 0.042, Pallelic = 0.008; OR = 2.7 and 95% CI 1.2–5.9, Pgenotype = 0.018, Pallelic = 0.023; OR = 4.7 and 95% CI 1.7–13.1, Pgenotype = 0.003, Pallelic = 0.014; and OR = 2.2 and 95% CI 1.1–4.8, Pgenotype = 0.04, Pallelic = 0.039 respectively). Moreover a cumulative genetic risk analysis revealed a significant trend for developing ALD with an increase in the number of risk alleles on IL10 and TGFβ1 loci among alcoholics. The risk genotype of IL1β and TGFβ1 also influences the total bilirubin, albumin and alanine aminotransferase levels among alcoholic “Bengalis”. The present study is the first case–control study from Eastern India that comprehensively identified polymorphic markers in TNFα, IL10, IL1β and TGFβ1 genes to be associated with ALD in the Bengali population, accentuating the significance of genetic factors in clinical expressions of ALD.