tbuckley/cabot-search huggingface dataset:
The Heart on the Right Side—No Right Lung.
Authors: J. A. Crook
Journal: JAMA (1890)

<h3>To the Editor:</h3> —Being called to one of our hotels about ten days ago to see a patient, as I was preparing to leave, a gentleman in the office asked me to feel his heart and see if I had ever seen anything like it. I found the heart to beat firmly and with unusual force against the right chest wall. I could detect no apex beat, but it seemed as if the whole side of the heart struck directly against the wall. I could detect no beat or sound on the left side. I saw clearly that he either had a displaced heart or that it was a congenital malformation. It being after tea, and having other engagements, I made no further examination, but asked him to call at my office at some convenient time to him, that I might make a thorough examination of his case. On the
Incidence and Prevalence of Diabetes in Children Aged 0–14 Years in Manitoba, Canada, 1985–1993
Authors: James F Blanchard, Heather Dean, Kristin Anderson, Andre Wajda, Sora Ludwig, Noella Depew
Journal: Diabetes Care (1997)

To estimate the incidence and prevalence of type I diabetes among Manitoba children aged 0-14 years from 1985-1993.The Manitoba Diabetes Database (a population-based database of individuals diagnosed with diabetes based on Manitoba's health insurance system) was used to estimate the annual incidence of diabetes for the years 1985-1993 and the point prevalence of diabetes at 31 March 1993 for Manitoba children aged 0-14 years. The Diabetes Education Resource for Children and Adolescents program database was used to correct incidence and prevalence rates for ascertainment using the two-source capture-recapture method.The overall ascertainment rate of the Manitoba Diabetes Database was 95% for incident cases and 93% for prevalent cases. The average annual incidence was 20.4 per 100,000 for children aged 0-14 years. The annual incidence appears to be stable for all age-groups 0-14 years over the past decade. The point prevalence of diabetes among children was 120.4 per 100,000.The incidence of type I diabetes in children aged 0-14 years in Manitoba is higher than reported previously in other urban regions of Canada, but similar to population-based estimates from Prince Edward Island. The incidence appears stable in Manitoba over the past decade even in the 0-4 year age-group. The Manitoba Diabetes Database appears to be a highly accurate population-based source of data on the epidemiology of diabetes in children.
Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells
Authors: Asish K. Ghosh, Tait D. Shanafelt, Amelia Cimmino, Cristian Taccioli, Stefano Volinia, Chang-gong Liu, George A. Calin, Carlo M. Croce, Denise A. Chan, Amato J. Giaccia, Charla Secreto, Linda E. Wellik, Yean K. Lee, Debabrata Mukhopadhyay, Neil E. Kay
Journal: Blood (2009)
Characteristics and outcome of patients with acute myeloid leukemia refractory to 1 cycle of high-dose cytarabine-based induction chemotherapy
Authors: Farhad Ravandi, Jorge Cortes, Stefan Faderl, Susan O'Brien, Guillermo Garcia-Manero, Srdan Verstovsek, Fabio P. S. Santos, Jianqin Shan, Mark Brandt, Marcos de Lima, Sherry Pierce, Hagop Kantarjian
Journal: Blood (2010)
Hematocrit and Plasma Volume in Runners
Authors: E. ERNST
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 October 1984Hematocrit and Plasma Volume in RunnersE. ERNST, A. MATRAIE. ERNSTSearch for more papers by this author, A. MATRAISearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-4-571_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Allow us to comment on the recent article by Stewart and colleagues (1). The authors found intestinal bleeding in runners (taking into account the uncertainties of the method used) and linked this finding to the runner's lower hematocrits.We have tested 14 semiprofessional male soccer players and found their average hematocrit to be 7% lower than that of age-and sex-matched controls. In another series, we have found that patients' individual hematocrits correlate with their work capacity on ergometer testing. In both studies we also have shown lower plasma viscosity in trained persons; this variable also correlates with...References1. STEWARTAHLQUISTMCGILLILSTRUPSCHWARTZOWEN JDDDSR. Gastrointestinal blood loss and anemia in runners. Ann Intern Med. 1984;100:843-5. LinkGoogle Scholar2. BROTHERHOODBROZOVÍCPUGH JBL. Haematological status of middle and long-distance runners. Clin Sci Mol Med. 1975;48:139-45. MedlineGoogle Scholar3. WILHERSONGUTINHORVATH JBS. Exercise-induced changes in blood red cell and plasma volumes in men. Med Sci Sports Exercise. 1977;9:155. Google Scholar4. NOVOSADOVA J. The changes in hematocrit, haemaglobin, plasma volume and proteins during and after different types of exercise. Eur J Appl Physiol. 1977;36:223. CrossrefGoogle Scholar5. COOKGUALTIERGALLA DWS. Body fluid volumes of college athletes and non-athletes. Med Sci Sports Exercise. 1970; 1:217. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University Clinics 8000 München 2 West Germany PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAbuse of recombinant erythropoietins and blood products by athletesHaematological and iron-related parameters of male endurance and strength trained athletesHemorheological treatmentAbuse of recombinant erythropoietins by athletes 1 October 1984Volume 101, Issue 4Page: 571-571KeywordsBlood plasmaHematocritHemorrhagePlasma volume Issue Published: 1 October 1984 PDF DownloadLoading ...
700 THE ANTIMICROBIAL PEPTIDE LL-37/CRAMP MODULATES LIVER-DISEASE IN MICE AND MEN
Authors: S. Wertenbruch, V. Grosarth, H. Drescher, M. Kaldenbach, S. Erschfeld, E. Bennek, D. Heinrichs, G. Sellge, C. Trautwein, L.-O. Brandenburg, K. Streetz
Journal: Journal of Hepatology (2013)
1360 PNPLA3 GG GENOTYPE IS ASSOCIATED WITH CAROTID ATHEROSCLEROSIS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
Authors: S. Petta, G. Parrinello, V. Di Marco, A. Licata, C. Cammà, M.R. Barcellona, D. Cabibi, S. Grimaudo, R.M. Pipitone, D. Torres, G. Marchesini, G. Licata, A. Craxi
Journal: Journal of Hepatology (2013)
Action of Salicylates
Authors: Stephen M. Krane
Journal: New England Journal of Medicine (1972)

IT is now almost 100 years since sodium salicylate was first introduced into medicine as an antipyretic and an anti-inflammatory agent for the treatment of rheumatic fever. The salicylates are now among the most widely used and abundantly consumed of all drugs. Many proprietary analgesic compounds also contain some salicylate perhaps to ensure a therapeutic effect. Despite their wide use and a better understanding of the metabolism of salicylates in man,1 the mechanisms whereby salicylates produce such diverse effects as analgesia, reduction of fever, increase in respiration and suppression of inflammation in connective tissue are not understood. Out of the . . .
Health Promotion and Obesity Research
Authors: Phil B. Fontanarosa
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Monozygotic Twins With Chronic Lymphocytic Thyroiditis (Hashimoto's Disease)
Authors: Monroe T. Diamond
Journal: JAMA (1966)

THE ETIOLOGY of chronic lymphocytic thyroiditis (Hashimoto's disease) is unknown. The theory that an autoimmune process is related to its pathogenesis was advanced by Roitt and co-workers<sup>1</sup>when they demonstrated several types of antibody against the thyroid in the sera of patients with this disease. The finding of thyroid antibodies in the relatives of patients with chronic lymphocytic thyroiditis<sup>2</sup>has suggested to some the possibility of genetic mechanisms acting in its causation, and the diagnosis of the disease in several members of the same family is considered compatible with this theory. Interest in this question of genetic predisposition increased with the demonstration of the disease in monozygotic female twins. Five sets of identical twins with chronic lymphocytic thyroiditis have been reported in the world literature.<sup>3-6</sup>A sixth pair is now described. <h3>Report of Cases</h3> A pair of 65-year-old female uniovular twins have been followed up for the
Effect of Various Oxygenation Conditions and Fluosed-DA on Cytotoxicity and Antitumor Activity of Blemoycin in Mice2
Authors: B. A. Teicher, S. A. Holden, K. N. S. Cathxcart
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Effect of Various Oxygenation Conditions and Fluosed-DA on Cytotoxicity and Antitumor Activity of Blemoycin in Mice2 Get access Beverly A. Teicher, Beverly A. Teicher 3Dana-Farber Cancer Institute, Harvard Medical School44 Binney St, Boston, MA 02115 Search for other works by this author on: Oxford Academic PubMed Google Scholar Sylvia A. Holden, Sylvia A. Holden 3Dana-Farber Cancer Institute, Harvard Medical School44 Binney St, Boston, MA 02115 Search for other works by this author on: Oxford Academic PubMed Google Scholar Kathleen N. S. Cathxcart Kathleen N. S. Cathxcart 3Dana-Farber Cancer Institute, Harvard Medical School44 Binney St, Boston, MA 021154Joint Center for Radiation Therapy, Harvard Medical School Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 8, 15 June 1988, Pages 599–603, https://doi.org/10.1093/jnci/80.8.599 Published: 15 June 1988 Article history Received: 11 December 1987 Revision received: 07 April 1988 Accepted: 13 April 1988 Published: 15 June 1988
TWO CASES OF HYPERTROPHY OF THE ADENOID TISSUE OF THE BASE OF THE TONGUE, ONE OF THEM PRODUCING "SERIOUS SYMPTOMS."Read in the Section of Laryngology and Otology at the Forty-first Annual Meeting of the American Medical Association, at Nashville, Tenn., May, 1890.
Authors: J. E. BOYLAN
Journal: JAMA (1890)

The pathological importance of the denser layer of lymphatic tissue which has been considered by various observers since Henle's time, and which Waldeyer has shown to exist, normally in an unbroken circle from the base of the tongue around the arcus glosso-palatinus to the tonsil of the fauces, from it to the tube lip and thence to the posterior upper pharyngeal wall on either side, was called into general notice some thirteen years ago by Meyer in his celebrated pa per on "Adenoid Vegetations." Since Meyer's communication, repeated investigation of the structure and dimensions of this "lymphatic ring" by Lenschker, Waldeyer, Gerlach, Schwartz, Trautman and others, has demonstrated that besides at the fauces, principally in two well defined regions, is this tissue massed in a similar manner to that between the pillars. In the vault of the pharnyx it exists no longer as a denser layer, but as
Contempo: Ethical Issues of Human Embryos Research and Physician-Assisted Suicide-Reply
Authors: Edward D. Pellegrino
Journal: JAMA (1995)

<h3>In Reply.</h3> —Dr Tauer and Dr Goodwin have misread my Contempo article. I appreciate the opportunity to correct their misreadings. Tauer is correct in saying that research using human embryos produced by in vitro fertilization without transfer to a human uterus was found acceptable from an ethical point of view by the EAB in 1979,<sup>1</sup>but my article did not claim that the Human Embryo Research Panel was the first to approve such research. Rather, it was first "to approve funding for the production of human embryos for research purposes."<sup>2</sup>This is a different matter. The 1994 Human Embryo Research Panel Report states specifically that one of its charges was "to provide advice as to areas that: (1) are acceptable for federal funding." It also states that "[t]he Panel supports funding of certain areas of preimplantation embryo research within the framework of the guidelines specified below."<sup>1</sup> In
Clinical Neurology for Psychiatrists
Authors: Carla Hellekson
Journal: JAMA (1986)

Dr Kaufman's second edition of Clinical Neurology for Psychiatrists deserves the attention of medical students, residents, practicing psychiatrists, and family practitioners. The two major sections of this 431-page text focus on a review of classical anatomic neurology and on major neurologic symptoms. The reader is captured quickly by the easily understood style and succinct reminders of definitions and pathways long ago heard and once learned. The ready informational flow from text to charts to drawings provides the counterpoints of reference so essential to learning the complexities of neurlogic diagnosis. The illustrators, Mr Morden and Ms Mannato, are to be commended for their ability to capture the essence of the varied presentations of individuals with neuropsychiatric disease. The references are very up to date, as are the citations of the classic articles in each area. Clinicians will find the multiple references for patient support groups very helpful.  Following a six-chapter review
URETHROTOMY BY THE COMBINED USE OF AN ANTERIOR AND POSTERIOR SOUND USED AS GUIDESTHE LATTER BY MEANS OF PREVESICAL PUNCTURE WITH A CURVED TROCAR CANNULA DESIGNED FOR THE PURPOSE.
Authors: G. W. PENN
Journal: JAMA (1904)

The genito-urinary surgeon or the general practitioner of medicine is confronted with no graver condition in the routine of practice than the fortunately rare impervious urethral stricture, as, with the patient anesthetized and the structures covering the urethral site divided, with or without a Wheelhouse staff or other guide, down to the stricture, he finds it simply impossible to locate the proximal lumen, or anything resembling the mucous membrane of the urethra. It is a well-known fact that the best genito-urinary surgeons are frequently baffled by this condition, and utterly fail to enter the bladder by the ordinary methods of urethrotomy, with or without a guide. The statement, "with a guide," refers to a catheter or staff introduced via the meatus and extending only down to the stricture, the usual meaning, "with a guide," obviously not being intended, since, of course, no difficulty could ensue if even the smallest filiform
Processed meat consumption and lung health: more evidence for harm
Authors: R. Varraso, C. A. Camargo
Journal: European Respiratory Journal (2014)

In the recent Global Burden of Disease study [1], chronic obstructive pulmonary disease (COPD) was the third most common cause of death worldwide in 2010. The predominant risk factor for COPD in the developed world is cigarette smoking, but up to one-third of COPD patients have never smoked, suggesting that other factors are involved. Relatively little attention has been paid to these other factors, such as diet, and how their modification might decrease the global burden of COPD. Nevertheless, the lungs exist in a high-oxygen environment and it is reasonable to posit that certain exposures (and local inflammation) can increase the burden of oxidants further. The balance between these potentially toxic substances and the protective actions of antioxidant defences, including those derived from diet, may play a role in the loss of lung function over time and the eventual development of COPD.

Based on this prevailing hypothesis, most of the diet–lung research to date has focused on dietary factors with antioxidant or anti-inflammatory properties, including: vitamin E (present in seed oils and nuts); vitamin C (fruits and vegetables); vitamin A, provitamin A carotenoids, and lycopene (fruits and vegetables); and selenium (seeds, seafood, and fish) [2]. In addition to these nutrients with antioxidant properties, the lipid composition of the diet ( e.g. omega-3 fatty acids) and vitamin D also have been studied for their potential role in lung health [2, 3]. Although most of the “promising” results for these nutrients have been from cross-sectional studies, a few longitudinal studies exist that demonstrate favourable associations between specific dietary factors and a slower decline of lung function or lower incidence of COPD. All of this nutrient-oriented research fails, in some respects, to appreciate the complexity of dietary assessment. For example, due to the fact we eat meals …
Capsule endoscopy for the small bowel in juvenile polyposis syndrome: a case series
Authors: A. Postgate, O. Will, C. Fraser, A. Fitzpatrick, R. Phillips, S. Clark
Journal: Endoscopy (2009)

Juvenile polyposis syndrome is one of the hamartomatous polyposis syndromes and demonstrates phenotypic heterogeneity. All patients with juvenile polyposis develop colorectal polyps and are at risk of colorectal cancer. Small-bowel involvement is variably described. Small-intestinal cancer is reported but is rare and there is no evidence-based protocol for small-intestinal surveillance. This case series reports the small-bowel capsule endoscopy findings and genetic mutational analyses of ten adults (7-male; median age 39.2 years, interquartile range 37.4 – 42.0 years) with documented juvenile polyposis syndrome. Two patients had small-bowel polyps beyond the range of standard gastroscopy identified at capsule endoscopy: a 6-mm ileal polyp in one, and 10-mm and 6-mm ileal polyps in the second (histology unknown). Duodenal polyps were detected in a third patient at capsule endoscopy. Three further patients had previously documented duodenal polyps at surveillance gastroscopy. A SMAD4 mutation was identified in seven patients but there was no obvious association with gastric/small-bowel polyp burden. In conclusion, capsule endoscopy provided information additional to conventional endoscopy in patients with juvenile polyposis syndrome and was well tolerated. However, no lesions requiring clinical intervention were identified and polyp numbers were small. Capsule endoscopy may appropriately be used as a baseline investigation for the identification of patients with large or dense small-bowel polyps for whom ongoing small-bowel investigation would be recommended. Patients in whom polyps are confined to the colon are unlikely to require ongoing small-bowel review.
Immunological Studies of Anemia in Malaria.
Authors: Eugene B. Rosenberg
Journal: Annals of Internal Medicine (1969)

s1 May 1969Immunological Studies of Anemia in Malaria.Eugene B. Rosenberg, M.D., G. Thomas Strickland, M.D., George E. Whalen, M.D., John E. Kostinas, M.D., Liang S. Yang, M.D.Eugene B. Rosenberg, M.D.Search for more papers by this author, G. Thomas Strickland, M.D.Search for more papers by this author, George E. Whalen, M.D.Search for more papers by this author, John E. Kostinas, M.D.Search for more papers by this author, Liang S. Yang, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1092_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe anemia of malaria cannot be attributed solely to erythrocytic destruction by malarial parasites since the anemia is often out of proportion to the parasitemia. The possibility of an immunologic mechanism contributing to the pathogenesis of this anemia was studied in 38 individuals with falciparum malaria and in 13 controls. Acute and convalescent plasma samples from American soldiers in Vietnam were assayed for IgA, IgG, IgM, and complement by a radial immunodiffusion technique.The mean IgM level in acute patients was 1.6 times the control mean (P< 0.05), and in convalescent patients the mean IgM level was 2.3 times... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Eugene B. Rosenberg, M.D.; G. Thomas Strickland, M.D.; George E. Whalen, M.D.; John E. Kostinas, M.D.; Liang S. Yang, M.D.Affiliations: Taipei Taiwan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1092-1092KeywordsAnemiaBlood plasmaMalariaParasitemiaPathogenesis ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
Corrected Structural Formulae of Amodiaquine and Related Agents
Authors: Harold O. Perry
Journal: JAMA (1962)

<h3>To the Editor:—</h3> A communication from Dr. Harold Aaron directed my attention to the fact that the structural formulae of the antimalarials outlined in our article entitled, "Nearly Fatal Reaction to Amodiaquine" (<i>JAMA</i><b>179</b>:598 [Feb. 24] 1962), were incorrectly presented and caused confusion in interpretation because of the abbreviated form in which they were drawn. The corrected formulae appear below:In addition, the text, paragraph 2, page 600, should be corrected as follows: "A variation in the radical attached to the 4-amino group accounts for the difference among these 3 compounds, each of which contains a 4-amino-7-chloroquinoline structure."
Cross-sectional echocardiographic examination of the interatrial septum.
Authors: J C Dillon, A E Weyman, H Feigenbaum, R C Eggleton, K Johnston
Journal: Circulation (1977)

The interatrial septum has not been readily appreciated by M-mode echocardiography. Cross-sectional echocardiography has the capability of recording the shape and location of the interatrial septum. Real-time cross-sectional echograms using a mechanically oscillating transducer were obtained on 100 consecutive patients. Echocardiographic examination of the left atrium and aorta was obtained in a plane perpendicular to the long axis of the atria. In 15 normal patients and 17 patients with atrial septal defects (ASD) and 51 patients with other forms of heart disease, the interatrial septum was recorded as a linear echo from the aorta to the posterior wall of the left atrium. In six patients who had ostium primum ASDs, the echoes from the interatrial septum disappeared near its expected junction with the interventricular septum. Drop out of echoes in the mid portion of the septum was noted in those patients who had ostium secundum atrial septal defects but this could not be differentiated from normal. These preliminary data indicate that examination of the interatrial septum is feasible and may be specific in those few patients examined so far with ostium primum atrial septal defect. The ability to locate and record the shape of the interatrial septum could have many investigate and clinical uses.
Efficacy of Lodoxamide Eye Drops on Mast Cells and Eosinophils after Allergen Challenge in Allergic Conjunctivitis
Authors: Stefano Bonini, Mauro Schiavone, Sergio Bonini, Laura Magrini, Pietro Lischetti, Alessandro Lambiase, Massimo G. Bucci
Journal: Ophthalmology (1997)