tbuckley/cabot-search huggingface dataset:
Association of paediatric mastocytosis with a polymorphism resulting in an amino acid substitution (M541L) in the transmembrane domain of c-KIT
Authors: R. Foster, E. Byrnes, C. Meldrum, R. Griffith, G. Ross, E. Upjohn, A. Braue, R. Scott, G. Varigos, P. Ferrao, L.K. Ashman
Journal: British Journal of Dermatology (2008)

Journal Article Association of paediatric mastocytosis with a polymorphism resulting in an amino acid substitution (M541L) in the transmembrane domain of c‐KIT Get access R. Foster, R. Foster School of Biomedical SciencesHunter Medical Research Institute Search for other works by this author on: Oxford Academic Google Scholar E. Byrnes, E. Byrnes School of Biomedical SciencesHunter Medical Research Institute Search for other works by this author on: Oxford Academic Google Scholar C. Meldrum, C. Meldrum Hunter Medical Research InstituteMedical Genetics, John Hunter Hospital, Newcastle, NSW, Australia Search for other works by this author on: Oxford Academic Google Scholar R. Griffith, R. Griffith Hunter Medical Research InstituteSchool of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia Search for other works by this author on: Oxford Academic Google Scholar G. Ross, G. Ross Department of Dermatology, Royal Children's Hospital, Parkville, Vic., Australia Search for other works by this author on: Oxford Academic Google Scholar E. Upjohn, E. Upjohn Department of Dermatology, Royal Children's Hospital, Parkville, Vic., Australia Search for other works by this author on: Oxford Academic Google Scholar A. Braue, A. Braue Department of Dermatology, Royal Children's Hospital, Parkville, Vic., Australia Search for other works by this author on: Oxford Academic Google Scholar R. Scott, R. Scott School of Biomedical SciencesHunter Medical Research InstituteMedical Genetics, John Hunter Hospital, Newcastle, NSW, Australia Search for other works by this author on: Oxford Academic Google Scholar G. Varigos, G. Varigos Department of Dermatology, Royal Children's Hospital, Parkville, Vic., Australia Search for other works by this author on: Oxford Academic Google Scholar P. Ferrao, P. Ferrao School of Biomedical SciencesHunter Medical Research Institute Search for other works by this author on: Oxford Academic Google Scholar ... Show more L.K. Ashman L.K. Ashman School of Biomedical SciencesHunter Medical Research Institute Correspondence: Leonie Ashman. E‐mail: leonie.ashman@newcastle.edu.au Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 159, Issue 5, 1 November 2008, Pages 1160–1169, https://doi.org/10.1111/j.1365-2133.2008.08827.x Published: 01 November 2008
Treat HIV-1 Infection Like Other Infections—Treat It
Authors: Bruce D. Walker
Journal: JAMA (1998)

Although the concept of delayed therapy is somewhat foreign to the field of infectious diseases, it has been supported by concerns about the long-term benefits of therapies currently available, the rigors of the currently available regimens, and the typically slow course of disease in persons with HIV-1 infection. Advances in treatment have been paralleled by recent advances in the understanding of HIV-1 pathogenesis, which provide important new insights as to how the virus is affected by immune selection pressure and why antiviral drug resistance is so prevalent. In our opinion, currently available data provide convincing arguments for initiation of therapy at the earliest possible juncture in persons who are not controlling viremia on their own.
SPHENOIDAL EMPYEMA AND EPIDEMIC CEREBRO-SPINAL FEVER
Authors: D. Embleton
Journal: BMJ (1920)

I~~~~~~~~~~~~~~~~~~~MECDICAL Jo'URNAL 7 obviQus bene#t to the rectal conditioun.Before recom- W xiending this-method of treatment.we should-require a body of evidence that cure of the rectal disease can really be anticipated in a fair proportion of cases.WVhen the rectum is affected above the peritoneal reflection, and is associated with abscess, evacuation of the abscess by the intraperitoneal route is to be recommended, but except for tlhe treatment of this complication operation has no service to offer. 4-Lastly, in selected cases, operation gives good results dlimitd tuberculous disease-f iesenteric glands.;Arxording to the extent and stage of tlhe focus this will take the form either of enucleation or of excision of the wesentery involved, together.with-associated bowel. SPHENOIDAL EMPYFMA AND EPIDEMICCfiREBRO-SPINAL PEVER.
Feverfew in rheumatoid arthritis: a double blind, placebo controlled study.
Authors: M Pattrick, S Heptinstall, M Doherty
Journal: Annals of the Rheumatic Diseases (1989)

Feverfew, reputed by folklore to be effective in arthritis, has in vitro properties that could be beneficial in the control of inflammatory disease. Forty one female patients with symptomatic rheumatoid arthritis received either dried chopped feverfew (70-86 mg) or placebo capsules once daily for six weeks. Allocation was random and not known by patient or observer. Variables assessed included stiffness, pain (visual analogue scale), grip strength, articular index, full blood count, erythrocyte sedimentation rate, urea, creatinine, C reactive protein, complement breakdown products (C3dg), rheumatoid factor titre, immunoglobulins (IgG, IgA, IgM), functional capacity, and patient and observer global opinions. One patient (placebo) withdrew after three days and was not included in the analysis. Treatment and placebo groups (20 patients each) were well matched at entry. No important differences between the clinical or laboratory variables of the groups were observed during the six week period. This study therefore shows no apparent benefit from oral feverfew in rheumatoid arthritis.
Standards for Patient Monitoring During Anesthesia at Harvard Medical School
Authors: John H. Eichhorn
Journal: JAMA (1986)

As part of a major patient safety/risk management effort, the Department of Anaesthesia of Harvard Medical School, Boston, has devised specific, detailed, mandatory standards for minimal patient monitoring during anesthesia at its nine component teaching hospitals. Such standards have not previously existed, and resistance to the concept was anticipated but not seen. The standards are technically achievable in all settings and affordable in terms of effort and cost. Early detection of untoward trends or events during anesthesia will result in prevention or mitigation of patient injury; this, in turn, may also help counter the explosive increases in anesthesia-related malpractice actions, settlements, judgments, and insurance premiums. The committee process used is applicable to the promulgation of standards of practice for all medical specialties and any organized group of medical practitioners.
THE EXPERT WITNESS.
Authors: F. J. GRONER
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biological activities of a human pluripotent hemopoietic colony stimulating factor on normal and leukemic cells.
Authors: E Platzer, K Welte, J L Gabrilove, L Lu, P Harris, R Mertelsmann, M A Moore
Journal: The Journal of Experimental Medicine (1985)

We studied the biological effects of pluripoietin, a human pluripotent hemopoietic colony-stimulating factor (CSF) purified from the 5637 bladder carcinoma cell line. We found that this human CSF appears to be a unique hemopoietic growth factor, differing from interleukin 3 (IL-3) by virtue of its leukemia differentiating activity in mouse and man, and from mouse granulocyte CSF, which does have differentiation-inducing activity, but lacks pluripoietic activity. In addition, differences from IL-3 were observed in cross-species activity on normal and leukemic cells.
Two-Year Safety and Efficacy of Ranibizumab 0.5 mg in Diabetic Macular Edema
Authors: Gabriele E. Lang, András Berta, Bora M. Eldem, Christian Simader, Dianne Sharp, Frank G. Holz, Florian Sutter, Ortrud Gerstner, Paul Mitchell
Journal: Ophthalmology (2013)
Acute Hepatitis With Myositis
Authors: Ira S. Schwartz
Journal: JAMA (1978)

To the Editor.—  The report by Pittsley et al (239:959, 1978) of a patient with acute hepatitis B having manifestations of dermatomyositis bears a similarity to a rapidly fatal case of hepatitis I recently studied.  Report of a Case.—  A 37-year-old woman complained of a sore throat, muscle weakness, arthralgia, and fever two weeks before hospitalization. On admission to the Mount Sinai Medical Center, her temperature was 40 °C; she appeared acutely ill, with generalized muscle tenderness and weakness of proximal muscle groups. No sensory deficit or rash was recorded. There had been no known exposure to toxins. The liver edge was palpated three fingers' breadth below the right costal margin. Notable laboratory test results included the following values: leukocytosis (27,000/cu mm) with a shift to the left; alkaline phosphatase, 271 mm/ml (normal, 30 to 90 mm/ml); SGOT, 258 units; SGPT, 132 units (normal, up to 50 units); hepatitis B
Relationship between total cholesterol/high-density lipoprotein cholesterol ratio, triglyceride/high-density lipoprotein cholesterol ratio, and high-density lipoprotein subclasses
Authors: Lianqun Jia, Shiyin Long, Mingde Fu, Bingyu Yan, Ying Tian, Yanhua Xu, Lantu Gou
Journal: Metabolism (2006)
Gene transfer into genomes of human cells by the sleeping beauty transposon system
Authors: Aron M Geurts, Ying Yang, Karl J Clark, Geyi Liu, Zongbin Cui, Adam J Dupuy, Jason B Bell, David A Largaespada, Perry B Hackett
Journal: Molecular Therapy (2003)

The Sleeping Beauty (SB) transposon system, derived from teleost fish sequences, is extremely effective at delivering DNA to vertebrate genomes, including those of humans. We have examined several parameters of the SB system to improve it as a potential, nonviral vector for gene therapy. Our investigation centered on three features: the carrying capacity of the transposon for efficient integration into chromosomes of HeLa cells, the effects of overexpression of the SB transposase gene on transposition rates, and improvements in the activity of SB transposase to increase insertion rates of transgenes into cellular chromosomes. We found that SB transposons of about 6 kb retained 50% of the maximal efficiency of transposition, which is sufficient to deliver 70–80% of identified human cDNAs with appropriate transcriptional regulatory sequences. Overexpression inhibition studies revealed that there are optimal ratios of SB transposase to transposon for maximal rates of transposition, suggesting that conditions of delivery of the two-part transposon system are important for the best gene-transfer efficiencies. We further refined the SB transposase to incorporate several amino acid substitutions, the result of which led to an improved transposase called SB11. With SB11 we are able to achieve transposition rates that are about 100-fold above those achieved with plasmids that insert into chromosomes by random recombination. With the recently described improvements to the transposon itself, the SB system appears to be a potential gene-transfer tool for human gene therapy.
Why study the epidemiology of asthma?
Authors: I Gregg
Journal: Thorax (1988)

Why study the epidemiology of asthma?Dr Peter Burney (June 1988;43:425-8) was right to insist that epidemiological research is as necessary in the elucidation of the pathogenesis of asthma as study of the underlying mechanisms.More questionable, however, is his confidence that it will pay good dividends, for up to now epidemiology's contribution to our understanding of asthma has been disappointingly small.'Improvement will come only when it
Spontaneous Peritonitis in Cirrhotic Ascites: A Decade of Experience.
Authors: Richard W. McCallum
Journal: Annals of Internal Medicine (1973)

Meeting Abstracts1 May 1973Spontaneous Peritonitis in Cirrhotic Ascites: A Decade of Experience.Richard W. McCallum, M.D., Noel Curry, M.B., Paul H. Guth, M.D., F.A.C.P.Richard W. McCallum, M.D.Search for more papers by this author, Noel Curry, M.B.Search for more papers by this author, Paul H. Guth, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-5-816_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSpontaneous peritonitis in cirrhosis has a reported prevalence of 3%. The recognition of six cases of spontaneous peritonitis over a 4-month period prompted a review of cases. In the decade beginning January 1963, 15 cases were diagnosed among approximately 4000 admissions for cirrhosis.The cause of cirrhotic ascites was Laënnec's cirrhosis in 13 patients and chronic active hepatitis in 2 patients. One patient was female; the patients' ages ranged from 33 to 62 years. Clinical presentations were fever and acute abdominal pain in eight cases, abdominal pain and shock in two, and chronic abdominal pain with either fever, increasing hepatic... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Richard W. McCallum, M.D.; Noel Curry, M.B.; Paul H. Guth, M.D., F.A.C.P.Affiliations: Los Angeles, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1973Volume 78, Issue 5Page: 816-816KeywordsAbdominal painAscitesChronic hepatitisCirrhosisFeversPeritonitisShock ePublished: 1 December 2008 Issue Published: 1 May 1973 PDF downloadLoading ...
Claudin-1 involved in neonatal ichthyosis sclerosing cholangitis syndrome regulates hepatic paracellular permeability
Authors: Brigitte Grosse, Doris Cassio, Nadya Yousef, Céline Bernardo, Emmanuel Jacquemin, Emmanuel Gonzales
Journal: Hepatology (2011)

Abstract Neonatal ichthyosis and sclerosing cholangitis (NISCH) syndrome is a liver disease caused by mutations of CLDN1 encoding Claudin-1, a tight-junction (TJ) protein. In this syndrome, it is speculated that cholestasis is caused by Claudin-1 absence, leading to increased paracellular permeability and liver injuries secondary to paracellular bile regurgitation. We studied the role of claudin-1 in hepatic paracellular permeability. A NISCH liver and polarized rat cell lines forming TJs, the hepatocellular Can 10 and the cholangiocellular normal rat choloangiocyte (NRC), were used. In contrast to NRC, Can 10 does not express claudin-1. Can 10 cells were transfected with a plasmid encoding Claudin-1, and stable Claudin-1-expressing clones were isolated. Claudin-1 expression was silenced by transfection with short interfering RNA in Can 10 clones and with short hairpin RNA in NRC. Claudin-1 expression was evaluated by quantitative reverse-transcriptase polymerase chain reaction, immunoblotting, and immunolocalization. Paracellular permeability was assessed by fluorescein isothiocyanate-dextran passage in both lines and by transepithelial resistance measurements in NRC. In the NISCH liver, Claudin-1 was not detected in hepatocytes or cholangiocytes. In Claudin-1 expressing Can 10 clones, Claudin-1 was localized at the TJ and paracellular permeability was decreased, compared to parental Can 10 cells, this decrease correlating with claudin-1 levels. Silencing of Claudin-1 in Can 10 clones increased paracellular permeability to a level similar to that of parental cells. Similarly, we observed an increase of paracellular permeability in NRC cells silenced for claudin-1 expression. Conclusion : Defect in claudin-1 expression increases paracellular permeability in polarized hepatic cell lines, supporting the hypothesis that paracellular bile leakage through deficient TJs is involved in liver pathology observed in NISCH syndrome. (Hepatology 2012)
Severe insulin-resistant diabetes mellitus in patients with congenital muscle fiber type disproportion myopathy.
Authors: H Vestergaard, H H Klein, T Hansen, J Müller, F Skovby, C Bjørbaek, M E Røder, O Pedersen
Journal: Journal of Clinical Investigation (1995)

Congenital muscle fiber type disproportion myopathy (CFTDM) is a chronic, nonprogressive muscle disorder characterized by universal muscle hypotrophy and growth retardation. Histomorphometric examination of muscle shows a preponderance of smaller than normal type 1 fibers and overall fiber size heterogeneity. Concomitant endocrine dysfunctions have not been described. We report the findings of altered insulin secretion and insulin action in two brothers affected with CFTDM and glucose intolerance as well as in their nonconsanguineous glucose-tolerant parents. Results are compared with those of six normoglycemic control subjects. All study participants underwent an oral glucose tolerance test to estimate insulin secretion. The oldest boy and his parents volunteered for studies of whole-body insulin sensitivity consisting of a 4-h euglycemic hyperinsulinemic clamp in combination with indirect calorimetry. Insulin receptor function and glycogen synthase (GS) activity and expression were examined in biopsies of vastus lateralis muscle. Despite a 45-90-fold increase in both fasting and postprandial serum insulin levels, both CFTDM patients had diabetes mellitus. Clamp studies revealed that the oldest boy had severe insulin resistance of both liver and peripheral tissues. The impaired insulin-stimulated glucose disposal to peripheral tissues was primarily due to reduced nonoxidative glucose metabolism. These changes were paralleled by reduced basal values of muscle GS total activity, allosterical activation of GS by glucose-6-phosphate, GS protein, and GS mRNA. The father expressed a lesser degree of insulin resistance, and studies of muscle insulin receptor function showed a severe impairment of receptor kinase activity. In conclusion, CFTDM is a novel form of severe hyperinsulinemia and insulin resistance. Whether insulin resistance is causally related to the muscle disorder awaits to be clarified.
STUDIES ON THE CIRCULATION IN MAN
Authors: G. N. Stewart
Journal: The Journal of Experimental Medicine (1913)

1. The blood flow in the feet is smaller per unit of volume of the part than in the hand, the ratio of foot flow to hand flow per 100 cubic centimeters of the part usually lying in normal persons between 1 to 3 and 1 to 2. 2. In the supine position, with the legs hanging down, the flow in the feet seems to be somewhat greater than in the sitting position.
SUBSTERILIZING INTRA-UTERINE RADIUM EXPOSURES: REPORT OF TWENTY-FIVE TREATMENTS
Authors: Douglas P. Murphy
Journal: JAMA (1927)

Intra-uterine radium radiation is practically a specific for benign menopausal hemorrhage. A permanent sterility follows the usual exposures employed. The use of short exposures is not so well or generally understood and is feared because of possible sterilizing effects. At the Rutherford Hospital between July 1, 1922. and Dec. 31, 1925, thirty-eight women in the child-bearing age received varying sized intra-uterine radium exposures all less than 1,000 millicurie hours each. One year following the last treatment, questionnaires were sent out and answers were received from twenty-five patients, or sufficient data were secured to make their records of value for this study. The accompanying table outlines the data received, which may be thus summarized: The age range of these patients was from 17 to 42 years, with an average of 28 years. All were white but two. Nineteen were married. Seventeen complained of metrorrhagia, seven of menorrhagia, while three of
Fc receptors in liver sinusoidal endothelial cells in NZB/W F1 lupus mice: A histological analysis using soluble immunoglobulin G–immune complexes and a monoclonal antibody (2.4G2)
Authors: Salahuddin Syed Ahmed, Hiroyuki Muro, Masahiko Nishimura, Isao Kosugi, Yoshihiro Tsutsui, Haruyuki Shirasawa
Journal: Hepatology (1995)

In systemic lupus erythematosus accompanied by the abnormal appearance of circulating immune complexes (ICs), Fc gamma receptor (FcR)-mediated IC handling in macrophages including Kupffer cells has been shown previously. However, sinusoidal endothelial cells (SECs) largely ingest soluble immunoglobulin (Ig) G-ICs through FcRs. In this study, the character, antigenic expression, and activity (i.e., ligand-binding capacity of SEC FcRs in NZB/NZW F1 lupus and NZW nonautoimmune mice) were immunohistochemically analyzed using monoclonal antibody (MAb) 2.4G2 to FcRs and peroxidase-antiperoxidase IgG as a ligand on cryosections. MAb 2.4G2 stained SECs and blocked the ligand binding of SEC FcRs in both mice strains. The staining intensities with MAb 2.4G2 in SECs and the FcR activities in SECs alone and all sinusoidal cells in both mice strains reached their maximum values at the age of 5 months. Staining intensities in NZB/W F1 were significantly higher at 1 and 2 months and lower at 9 months than those in NZW. The number of Kupffer cells detected by MAb F4/80 to macrophages in both mice strains gradually increased until 5 months, but their number in NZB/W F1 at 9 months was twice as large as that in NZW. In conclusion, SEC FcRs in mice are low-affinity FcRs that react with MAb 2.4G2. The data of FcR activity suggest no impairment of the FcR-mediated IgG-IC binding on SECs in NZB/W F1 in early life.(ABSTRACT TRUNCATED AT 250 WORDS)
Is a second ligation necessary in endoscopic submucosal resection of rectal carcinoid tumors?
Authors: K.-I Fu, Y. Mashimo, T. Matsuda, Y. Saito, Y. Sano
Journal: Endoscopy (2006)

With great interest, we have read the article of Moon et al. on endoscopic submucosal resection with a double ligation technique for treatment of rectal carcinoid tumors [1]. They have modified our technique of endoscopic submucosal resection with a ligation device (ESMR-L) [2]; that is, they have applied a second detachable snare to ligate the stalk below the elastic band and performed snare resection above the elastic band. They have employed this modified technique for complete removal of 11 rectal carcinoid tumors, without immediate or late complication such as bleeding or perforation. They concluded that it is a useful and safe method for the treatment of small rectal carcinoid tumors.