tbuckley/cabot-search huggingface dataset:
Peutz-Jeghers Syndrome
Authors: Lloyd G. Bartholomew
Journal: JAMA (1963)

<h3>To the Editor:</h3> —Recently, in reviewing an issue ofThe Journal(<b>181:</b>989 [Sept 15] 1962), I was particularly interested in the article by Dr. Harvey Blank of Miami, Fla. He made the statement in regard to Peutz-Jeghers syndrome that not all of the patients have polyps but that polyps should be sought because of the possibility of intestinal carcinoma developing. I think that this statement is somewhat misleading, in that, to date, in more than 182 cases reported in the literature, there have been no instances reported of the development of a metastatic lesion from any of these polyps. Correctly, these polyps should be sought for because they may cause difficulty by recurrent episodes of intussusception and intestinal obstruction. They also may cause chronic hypochromic anemia and sometimes produce a severe gastrointestinal hemorrhage. In a recent review of the cases seen at the Mayo Clinic and those reported in
Long-term follow-up of patients with chronic hepatitis C treated with α-interferon
Authors: Michiko Shindo, Adrian M. di Bisceglie, Jay H. Hoofnagle
Journal: Hepatology (1992)

We reanalyzed the results of a pilot study of recombinant alpha-interferon therapy for chronic non-A, non-B hepatitis in light of the recent discovery of the hepatitis C virus and the development of diagnostic assays for this agent. Stored serum samples from 10 patients treated between 1984 and 1986 were tested for antibody to hepatitis C virus and hepatitis C virus RNA before, during and after therapy. In addition, the current clinical, serum biochemical and virological statuses of these patients were evaluated to determine the long-term effects of interferon therapy. All patients had evidence of hepatitis C virus infection, with hepatitis C viral RNA, antibody to hepatitis C virus or both markers detectable in serum. Serum hepatitis C virus RNA was found to disappear in seven of eight patients whose aminotransferase levels became normal with interferon therapy but remained present in two patients who did not respond to therapy. Levels of hepatitis C virus RNA decreased and disappeared when serum aminotransferases fell to normal levels but rose with subsequent elevation of aminotransferase levels in two patients who had relapses in disease when interferon was stopped. During a follow-up of 3 to 6 yr, hepatitis C virus RNA remained undetectable in the six patients whose serum aminotransferase levels remained normal after interferon therapy. However, neither initial titers of hepatitis C virus RNA nor disappearance of viral RNA from serum during treatment predicted a sustained response. Thus long-term beneficial responses to alpha-interferon can occur in patients with chronic hepatitis C and are associated with sustained loss of hepatitis C virus RNA from serum.
A randomized, double-blind, placebo-controlled, Phase I/II trial of RNActive®-vaccine cv9104 in patients with metastatic castrate-refractory prostate cancer (mcrpc): first results of the Phase I part
Authors: Sven D Koch, Henoch Hong, Susan Feyerabend, Margitta Retz, Hubert Kuebler, Axel Heidenreich, Thomas van Erps, Andreas Schroeder, Birgit Scheel, Valérie Reus, Karl-Josef Kallen, Mariola Fotin-Mleczek, Ulrike Gnad-Vogt, Arnulf Stenzl
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts CV9104 is a novel mRNA-based therapeutic vaccine for prostate cancer encoding the prostate cancer-associated antigens PSA, PSMA, PSCA, STEAP, PAP and MUC1 by engineered mRNA molecules optimized for protein expression and immunostimulation (RNActive®). CV9103, an mRNA-based
Oxford and the Savannah: Can the Hippo Provide an Explanation for Peto's Paradox?
Authors: Fergal C. Kelleher, Hazel O'Sullivan
Journal: Clinical Cancer Research (2013)

Peto's paradox is the counterintuitive finding that increasing body mass and thereby cell number does not correlate with an increase in cancer incidence across different species. The Hippo signaling pathway is an evolutionarily conserved system that determines organ size by regulating apoptosis and cell proliferation. It also affects cell growth by microRNA-29 (miR-29)-mediated cross-talk to the mTOR signaling pathway. Whether these pathways that decide organ size could explain this paradox merits consideration. Inactivation of most genes of the Hippo pathway in Drosophila melanogaster genetic screens causes excessive tissue-specific growth of developing tissues. Altered Hippo pathway activity is frequently found in diverse tumor types, but mutations of component pathway genes are rare. Most Hippo pathway components are encoded by tumor suppressor genes (TSG), but an exception is the downstream effector gene called YAP. Activity of the Hippo pathway causes deactivating phosphorylation of YES-associated protein (YAP) with nuclear exclusion. YAP can also be phosphorylated at a second site, S127, by AKT. YAP induces the expression of genes responsible for proliferation and suppression of apoptosis. Resolving Peto's paradox may serendipitously provide new insights into the biology and treatment of cancer. This article considers Hippo signaling and Peto's paradox in the context of TSG-oncogene computed models. Interspecies differences in dietary composition, metabolic rates, and anabolic processes are also discussed in the context of Hippo-mTOR signaling. The metabolically important LKB1-AMPK (liver kinase B1-AMP activated protein kinase) signaling axis that suppresses the mTOR pathway is also considered.
Isolation and characterization of tyrosinase inhibitors and their differential action on melanogenic subcellular compartments in amelanotic and melanotic melanomas
Authors: GENJI IMOKAWA, YUTAKA MISHIMA
Journal: British Journal of Dermatology (1980)

Further purification of highly active tyrosinase inhibitors by DEAE-Sephadex column chromatography has revealed that the mode of action of the inhibitors from melanomas with different melanogenic status is organelle specific. The inhibitor from amelanotic melanoma has a relatively strong suppressive effect on the tyrosinases in GERL and coated vesicle containing fractions. On the other hand, the inhibitor from melanotic melanoma has no substantial effect on these tyrosinases, although melanosomal tyrosinase is inhibited by both. The present evidence suggests that the defect of melanization in amelanotic melanoma in vivo is related to the tyrosinase inhibition of the smooth membrane system including GERL and coated vesicle by the highly active inhibitor characteristic of amelanotic melanoma.
Top Cancer News Stories of 1989 Show Wide Media Coverage
Authors: Julie Neild
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Top Cancer News Stories of 1989 Show Wide Media Coverage Get access Julie Neild Julie Neild Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 1, 3 January 1990, Pages 15–16, https://doi.org/10.1093/jnci/82.1.15 Published: 03 January 1990
SIRE1, an Endogenous Retrovirus Family from Glycine max, Is Highly Homogeneous and Evolutionarily Young
Authors: Howard M. Laten, Ericka R. Havecker, Lisa M. Farmer, Daniel F. Voytas
Journal: Molecular Biology and Evolution (2003)

SIRE1 is unusual among Ty1-copia retrotransposons in that it has an additional open reading frame with structural features similar to retroviral envelope proteins between pol and the 3′ LTR. Here we report the characterization and comparison of eight different SIRE1 elements derived from a soybean genomic library, as well as SIRE1 reverse transcriptases from Glycine soja. The DNA sequences of the eight SIRE1 elements are highly homogeneous and share greater than 95% nucleotide identity. Partial sequences obtained from BAC ends are similarly conserved. Phylogenetic analyses resolve two closely related SIRE1 lineages, and nucleotide changes within and between SIRE1 lineages have occurred to preserve function. Both the gag and the env-like genes are evolving under similar levels of functional constraint. Considerable sequence heterogeneity in the form of short duplications was found within the LTRs and in the region between the envelope-like ORF and the 3′ LTR. These duplications are suggestive of slippage by reverse transcriptase during replication. Sequence identity between LTRs of individual insertions suggests that they transposed within the past 70,000 years. Two of 10 SIRE1 insertions examined abut Ty3-gypsy retroelements. Since the soybean genome harbors more than 1,000 SIRE1 insertions, the collective data suggest that SIRE1 has undergone a very recent and robust amplification in soybean.
Utility of Childhood Glucose Homeostasis Variables in Predicting Adult Diabetes and Related Cardiometabolic Risk Factors: The Bogalusa Heart Study
Authors: Giuseppe d'Annunzio, Chiara Russo, Renata Lorini
Journal: Diabetes Care (2010)

The article by Nguyen et al. (1) assessed the usefulness of the childhood glucose homeostasis variable homeostasis model assessment of insulin resistance (HOMA-IR) in predicting pre-diabetes and type 2 diabetes and cardiometabolic risk factors in adulthood. In the investigators' retrospective cohort study of adults aged 19–39 years who were followed for 17 years since adulthood, at least 50% of the subjects who ranked the highest (top quintile) for HOMA-IR in childhood maintained their rank …
Testing Drugs: Men, Mice and Baboons
Authors: F.J. Ingelfinger
Journal: New England Journal of Medicine (1975)

In evaluating the overall utility of a pharmacologic agent, safety rather than efficacy is often of primary concern. No one questions, for example, the sedative effects of certain tranquilizers, the hypotensive action of reserpine, or the stimulation produced by infusa of the coffee bean, but their safety has been challenged by observational studies of human experience. Others, however, dispute such conclusions, even though the species studied is the same.1 Although physicians and their patients may find such contradictions puzzling, they probably are equally if not more nonplussed by extrapolations to man of adverse effects detectable in subhuman forms of life. . . .
A New Addition to the Journal of Clinical Oncology: The Art of Oncology—When the Tumor Is Not the Target
Authors: Charles L. Loprinzi, George P. Canellos
Journal: Journal of Clinical Oncology (2000)

Article Tools EDITORIAL Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2000.18.1.3 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 10623686 A New Addition to the Journal of Clinical Oncology: The Art of Oncology—When the Tumor Is Not the Target Charles L. LoprinzixCharles L. LoprinziSearch for articles by this author , George P. CanellosxGeorge P. CanellosSearch for articles by this author https://doi.org/10.1200/JCO.2000.18.1.3 Full Text PDF Figures and Tables "A New Addition to the Journal of Clinical Oncology: The Art of Oncology—When the Tumor Is Not the Target." Journal of Clinical Oncology, 18(1), p. 3© 2000 by American Society of Clinical Oncology
Anesthesia and recent myocardial infarction
Authors: J. G. Fraser
Journal: JAMA (1967)

A review has been made of mortality statistics associated with surgery in patients with recent myocardial infarction. The overall mortality figures compare closely with those of coronary-disease patients not involved in surgery or anesthesia. Our findings support the concept that elective surgery should be postponed until the end of the healing stage (three months). Essential surgery performed during the early postinfarction period carried a very high risk. The prognosis following surgery performed after the first 15 days postinfarction was significantly improved.
A STUDY OF THE SPINAL CORD BY NISSL'S METHOD IN TYPHOID FEVER AND IN EXPERIMENTAL INFECTION WITH THE TYPHOID BACILLUS
Authors: Joseph Longworth Nichols
Journal: The Journal of Experimental Medicine (1899)

(1) The application of the Nissl method to the study of the motor cells of the spinal cord, and the nerve cells of the dorsal root ganglia in typhoid fever, shows that these cells regularly suffer pathological changes in the course of the infection. (2) The alterations in the motor cells are more constant and of a severer grade than are those in the cells of the sensory ganglia. The more characteristic changes consist of disintegration, solution and destruction of the chromatic substance of the cell starting from the axone hillock and proceeding toward the nucleus. Coincidently the nuclei of the affected cells seek the periphery. Alterations are also suffered by the nucleus and nucleolus. (3) While this central form of ehromatolysis is the prevailing type of pathological change, disintegration, etc., of the Nissl bodies situated in the periphery of the cell and in the dendrites is also observed (peripheral chromatolysis). (4) In experimental infection with typhoid bacilli in rabbits a similar series of lesions in the corresponding nerve cells in the spinal cord and ganglia is encountered. (5) The main or central type of lesions discovered is identical with that found in man and animals after section, destruction, or even slight injury of the peripheral nerves. (6) The examination of the peripheral nerves arising from the lumbar segment of the cord (the site in man and rabbit of the most profound changes) in rabbits inoculated with typhoid bacilli showed well-marked evidences of parenchymatous degeneration. (7> It is probable that lesions of the peripheral nerves in typhoid fever in human beings are common and that the post-typhoid hyper sthesias and paralyses are due to this cause. (8) Restitution of the chromatic granules may take place in the affected nerve cells, the new formation beginning about the nucleus and extending through the protoplasm.
THE TREATMENT OF CHEONIC PARONYCHIA.
Authors: A. B. SHRANK, S. S. BLEEHEN
Journal: British Journal of Dermatology (1965)

Journal Article THE TREATMENT OF CHEONIC PARONYCHIA. Get access A. B. SHRANK, M.A., M.R.C.P., A. B. SHRANK, M.A., M.R.C.P. Skin Department, Middlesex Hospital, London, W.I Search for other works by this author on: Oxford Academic Google Scholar S. S. BLEEHEN, M.B., M.R.C.P. S. S. BLEEHEN, M.B., M.R.C.P. Skin Department, Middlesex Hospital, London, W.I Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 77, Issue 7, 1 July 1965, Pages 385–387, https://doi.org/10.1111/j.1365-2133.1965.tb14666.x Published: 01 July 1965
Effects of Inhalation of Steroids on Lung Permeability in Patients With Asthma
Authors: SHYH-JEN WANG, CHIA-HUNG KAO, WAN-YU LIN, CHUNG-YUAN HSU, CHENG-PEI CHANG, JOANG-LIANG LAN
Journal: Clinical Nuclear Medicine (1995)

This study evaluated the effect of inhalation of steroids on lung permeability in patients with asthma by measuring the clearance of Tc-99m DTPA aerosol from the alveolar to vascular space. Twenty patients with asthma were studied in the supine position with a gamma camera and the clearance half time (T 1/2) was calculated. The base line lung permeability study was performed before treatment with inhalation of 100 µg beclomethasone diproplonate four times daily for 1 week, then the study was repeated. After treatment with inhalation of steroid, there was a change in T 1/2 from 76.4 +/− 37.4 minutes to 86.6 +/− 48.2 minutes (P = 0.08). This preliminary study suggests that lung permeability is not altered by inhaled steroid therapy.
Correlation analysis of stair climbing test, anaerobic threshold in cardiopulmonary exercise testing &amp; length of hospital stay in patients undergoing repair of abdominal aortic aneurysm (AAA)
Authors: Junaid Khan, Fayyaz Mazari, George Smith, Nehmiah Samuel, Risha Gohil, Ian Chetter, Peter McCollum
Journal: International Journal of Surgery (2011)
FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23)
Authors: K Kojima, I Sakai, A Hasegawa, H Niiya, T Azuma, Y Matsuo, N Fujii, M Tanimoto, S Fujita
Journal: Leukemia (2004)
Author's reply to Girling
Authors: H. Angus-Leppan
Journal: BMJ (2014)

Girling correctly mentions eclampsia as a cause of tonic-clonic seizure.1 In my article, only the most common causes of symptomatic seizure could be mentioned.2 Eclampsia is a rare cause of symptomatic first seizure (structural/metabolic seizure in the new terminology).3 4 Many other rare causes were also not discussed, …
POSSIBILITIES FOR THE THERAPEUTIC CONTROL OF FIBROSIS
Authors: C.I. Levene
Journal: British Journal of Dermatology (1985)

Journal Article POSSIBILITIES FOR THE THERAPEUTIC CONTROL OF FIBROSIS Get access C.I. Levene C.I. Levene Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 112, Issue 3, 1 March 1985, Pages 363–371, https://doi.org/10.1111/j.1365-2133.1985.tb04866.x Published: 01 March 1985
The Iron-Enrichment-Now Brouhaha
Authors: William H. Crosby
Journal: JAMA (1975)

I THANK Dr. Lasagna for his letter (p 1027). Any accusation of fraud should be substantiated on the public record. I traveled to Rockville, Md, in April to testify before a hearing judge of the Food and Drug Administration (FDA) concerning the merits of the FDA Commissioner's proposal to mandate a further iron fortification of bread and flour. The proposal had been published by the FDA on Dec 3, 1971. It was defended in a long article in the<i>Federal Register</i>of Oct 15, 1973, signed by A. M. Schmidt, Commissioner of Food and Drugs. In discussing my testimony with counsel, I pointed out that the Commissioner's statement is seriously flawed by claims and arguments that are palpably false. I was advised by counsel to refrain from any such statement. To criticize the Commissioner in an FDA hearing would be like going into a church and criticizing God. So I
Endocardial Cushion Defect
Authors: LEWIS P. SCOTT, ANNA J. HAUCK, ALEXANDER S. NADAS, ROBERT E. GROSS
Journal: Circulation (1962)

Preoperative and postoperative data on 44 patients with endocardial defect, 32 with the incomplete and 12 with the Complete form are presented. Nineteen per cent of the incomplete form died with per cent of the deaths occurring early and 9.5 per cent late. The mortality rate for the complete form was 75 per cent. Late follow-up results were evaluated in 28 patients 1 to 2½ years following surgery. Catheterization data in nine of 10 and clinical observations in 18 indicated no residual shunt. One patient showed questionable evidence of a left-to-right shunt by cardiac catheterization. Evidence of mitral regurgitation was present in seven (25 per cent) of the survivors. Short chordae attaching the closed cleft margin of the mitral leaflet to the ventricular septum rendered the valve incompetent in nine of 12 autopsied specimens. Surgical exploration of the underside of the cleft margins for such chordae is recommended. No evidence of residual tricuspid regurgitation was found.
Reviews and Notes: Resampling Stats for Macintosh
Authors: Randy L. Anderson
Journal: Annals of Internal Medicine (1996)

Literature of Medicine15 May 1996Reviews and Notes: Resampling Stats for MacintoshRandy L. Anderson, PhDRandy L. Anderson, PhDQuintiles, Inc., Research Triangle Park, NC 27709Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-10-199605150-00045 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Version 4.0.1. Julian L. Simon. Arlington, VA: Resampling Stats, Inc.; 1995. $225.00. 1 3.25-inch diskette, packaged with Operations Guide, User's Guide, and Resampling Stats: The New Statistics.Macintosh requirements: Classic or later, 1 MB RAM, System 6.0 to 7.5, math coprocessor recommended.Resampling statistics are analysis techniques based on the generation of many samples of observations by permutation from a reference set of all possible values. Unlike classic inferential procedures, inference based on resampling does not depend on distributional assumptions, as do the t-test and analysis of variance. Descriptive statistics, such as proportions or means, are computed for each permuted ... Author, Article, and Disclosure InformationAffiliations: Quintiles, Inc., Research Triangle Park, NC 27709 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 May 1996Volume 124, Issue 10Page: 937-938KeywordsAnalysis of varianceMonte Carlo methodStatistical distributionsStatistical methods ePublished: 15 August 2000 Issue Published: 15 May 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
On the "Angry Medical Student's" Lament for "Better" Teaching
Authors: David Seegal
Journal: JAMA (1967)

Despite the Herculean efforts of many committees on curriculum it is doubtful that the ideal educational program will be achieved in any medical school. The multiple factors of teachers, students, subjects, and changing scientific and social scenes present so many complex and unsettled problems that only an approximation of excellence may be anticipated in solving these dilemmas. For example, it is unlikely that the controversy as to the relative educatory merits of the full-time university member and the extrahospital practitioner will be quickly resolved to everyone's satisfaction; and it is a safe wager that students will continue to denigrate the teaching performance of many members of the faculty. Recently these controversial matters have stimulated perceptive and empathic responses by Lawrence A. Kohn, 1 Eugene A. Stead, 2 and Carl V. Moore. 3 Moore addresses his remarks particularly to the angry medical students' complaints about the inadequacies of their medical education.