tbuckley/cabot-search huggingface dataset:
Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes
Authors: Manlio Vinciguerra, Antonino Sgroi, Christelle Veyrat-Durebex, Laura Rubbia-Brandt, Leo H. Buhler, Michelangelo Foti
Journal: Hepatology (2008)

Abstract Phosphatase and tensin homolog (PTEN) is a regulator of phosphoinositide 3-kinase signaling and an important tumor suppressor mutated/deleted in human cancers. PTEN deletion in the liver leads to insulin resistance, steatosis, inflammation, and cancer. We recently demonstrated that unsaturated fatty acids trigger steatosis by down-regulating PTEN expression in hepatocytes via activation of a mammalian target of rapamycin (mTOR)/nuclear factor kappa B (NF-κB) complex, but the molecular mechanisms implicated in this process are still unknown. Here, we investigated potential genetic and epigenetic mechanisms activated by fatty acids leading to PTEN down-regulation. Our results indicate that unsaturated fatty acids down-regulate PTEN messenger RNA expression in hepatocytes through mechanisms unrelated to methylation of the PTEN promoter, histone deacetylase activities, or repression of the PTEN promoter activity. In contrast, unsaturated fatty acids up-regulate the expression of microRNA-21, which binds to PTEN messenger RNA 3′-untranslated region and induces its degradation. The promoter activity of microRNA-21 was increased by mTOR/NF-κB activation. Consistent with these data, microRNA-21 expression was increased in the livers of rats fed high-fat diets and in human liver biopsies of obese patients having diminished PTEN expression and steatosis. Conclusion: Unsaturated fatty acids inhibit PTEN expression in hepatocytes by up-regulating microRNA-21 synthesis via an mTOR/NF-κB–dependent mechanism. Aberrant up-regulation of microRNA-21 expression by excessive circulating levels of fatty acids exemplify a novel regulatory mechanism by which fatty acids affect PTEN expression and trigger liver disorders. (Hepatology 2009.)
Liver and Brain Scans-Reply
Authors: Robert E. Wittes
Journal: JAMA (1977)

<h3>In Reply. —</h3> Both questions raised by Dr Silberstein are valid. It is well known that the lateral view of liver scans may detect lesions missed by performing anterior scan alone.<sup>1,2</sup>Only lesions larger than 2 cm located on the surface of the liver can be easily detected. The collimator, the intrinsic resolution of the detecting system, the respiratory motion of the patients, and the concurrent parenchymal liver disease can all influence the overall accuracy of liver scans. Data from the early studies from our laboratory<sup>3</sup>do not seem to be substantially different from other series compiled recently by Brill and Patton.<sup>4</sup>The overall accuracy of the liver scan did not appear to change substantially with the improvement of radiopharmaceuticals, instrumentation, or the use of multiple images.<sup>5</sup>Any increase in the detection of early liver lesions when lateral scans are performed in every case is probably
The origin of post-injury neointimal cells in the rat balloon injury model
Authors: Luis Rodriguez-Menocal, Melissa St-Pierre, Yuntao Wei, Sheik Khan, Dania Mateu, Marian Calfa, Amir A. Rahnemai-Azar, Gary Striker, Si M. Pham, Roberto I. Vazquez-Padron
Journal: Cardiovascular Research (2008)

The origin of post-injury neointimal cells is still a matter of debate. This study aims to determine the anatomic source of neointimal cells in one of the most important animal models for the study of vascular stenosis in response to injury, the rat balloon injury model.Chimeric rats were generated by rescuing lethally irradiated animals with green fluorescent protein (GFP)(+) bone marrow (BM) cells from transgenic rats. Neointimal formation was induced in the right iliac artery of these animals using a balloon angioplasty catheter. Injured and non-injured contra-lateral arteries were harvested at 7, 14, and 30 days post-surgery. BM-derived monocytes/macrophages (CD68(+) GFP(+)) were abundant in the media and adventitia of injured vessels harvested at 7 days as determined by immunofluorescence and confocal microscopy. The number of GFP(+) cells declined in the vascular wall with time. Post-injury neointimal cells were mostly GFP(-)/smooth muscle actin (SMA)(+), which indicated that those cells originated in the recipient. Only a few neointimal cells seemed to come from circulating progenitors (GFP(+) SMA(+), 2.34% +/- 1.61). The vascular origin of cells in the neointima was further confirmed by transplanting injured GFP arteries into wild-type recipients. In these grafts, 94.23 +/- 0.44% of medial and 92.95 +/- 19.34% of neointimal cells were GFP(+) SMA(+). Finally, we tested the capacity of vascular smooth muscle cells (VSMC) to migrate through the vascular wall using a novel in vivo assay. As expected, VSMC migrated and populated the neointima only in response to injury.Our results suggest that neointimal cells in the rat balloon injury model mostly derive from pre-existing vascular cells and that only a small population of those cells come from BM-derived progenitors.
LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase.
Authors: M P Manns, K J Griffin, K F Sullivan, E F Johnson
Journal: Journal of Clinical Investigation (1991)

LKM-1 autoantibodies, which are associated with autoimmune chronic active hepatitis, recognize P450IID6, a cytochrome P-450 monooxygenase. The reactivities of 26 LKM-1 antisera were tested with a panel of deletion mutants of P450IID6 expressed in Escherichia coli. 22 sera recognize a 33-amino acid segment of P450IID6, and 11 of these recognize a shorter segment, DPAQPPRD. PAQPPR is also found in IE175 of herpes simplex virus type 1 (HSV-1). Antibodies for HSV-1 proteins were detected by ELISA in 17 of 20 LKM-1 sera tested. An immobilized, synthetic peptide, DPAQPPRDC, was used to purify LKM-1 antibodies. Affinity purified LKM-1 autoantibodies react on immunoblots with a protein in BHK cells after infection with HSV-1. 11 of 24 LKM-1 sera, including 3 that recognize DPAQPPRD, also exhibit antibodies to the hepatitis C virus (HCV) protein, C100-3. Affinity purified LKM-1 antibodies did not recognize C100-3. However, partial sequence identity was evident between portions of the immunopositive 33-amino acid segment of P450IID6 and other portions of the putative HCV polyprotein. Immune cross-recognition of P450IID6 and HCV or HSV-1 proteins may contribute to the occurrence of LKM-1 autoantibodies.
Evaluation of an automated bleeding time device in the newborn
Authors: Maureen Andrew, Bosco Paes, Jan Bowker, Patsy Vegh
Journal: American Journal of Hematology (1990)

Abstract Sick infants frequently develop impaired hemostasis as a secondary event. Abnormal platelet‐vessel wall interaction contributes to the hemorrhagic side effects. Currently, the bleeding time is the best measure of in vivo platelet participation in small vessel hemostasis. Bleeding times in the newborn have been previously determined with an automated device designed for the adult or with nonautomated devices. The automated bleeding time device for the adult is not suitable for the infant (length 5 mm, depth 1 mm). We evaluated the performance of an automated bleeding time device designed specifically for the newborn making a cut 2.5 mm in length and 0.5 mm in depth. The results with the automated device showed a strong correlation with the modified template bleeding time device previously used for the newborn. The normal range was shorter and the sensitivity to abnormal vessel wall interaction was greater with the automated device. As well, the ease of determining the bleeding time with the automated device was considerably improved over the template device.
Drug company targets US state health officials
Authors: Ray Moynihan
Journal: BMJ (2004)

A major pharmaceutical company has sought to influence state government officials with trips, perks, lavish meals, and other payments, says an investigator from the Pennsylvania Office of Inspector General.

Investigator Allen Jones told the BMJ earlier this week that he had discovered that the drug company Janssen was sponsoring educational events for state employees, funding individuals' travel arrangements, and paying honorariums of up to $2000 (£1100; €1610) each to key officials who held influence over the drugs prescribed in state-run prisons and mental hospitals.

Yet as his investigations widened, Mr Jones was …
Prognosis of chronic spontaneous urticaria in 117 patients not controlled by a standard dose of antihistamine
Authors: M. Hiragun, T. Hiragun, S. Mihara, T. Akita, J. Tanaka, M. Hide
Journal: Allergy (2012)

Abstract Background Chronic spontaneous urticaria ( CSU ) is a common skin disorder, but its clinical course reported so far is largely variable, probably due to the heterogeneity of the clinical background of patients and pathogenesis of this disease. Methods To reveal the prognosis of refractory CSU , we retrospectively studied the patients who suffered from spontaneous urticaria for six weeks or longer at their first visit to our outpatient clinic, who were insufficiently controlled by a standard dose of antihistamine, and revisited from 2003 to 2009. Results Among 223 patients with CSU , 117 patients fulfilled the criteria mentioned above. Mean disease duration at first visit and mean duration of follow‐up at our hospital were 27.4 ± 4.2 months and 18.7 ± 1.9 months, respectively. By using K aplan– M eier methods, the estimated improved rates at 12 months, 24 months, and 60 months were 36.6%, 51.2%, and 66.1%, respectively. The overall improvement rate of childhood cases (&lt;19 years) was significantly higher than that of adult cases ( P = 0.007, log‐rank test). Moreover, the improvement rate of patients with short disease durations (&lt;1 year at the first visit) was significantly ( P = 0.003, log‐rank test) higher than that of patients with long disease durations (one year or more). Conclusion Our data indicate that the condition of patients with CSU can be gradually improved even in intractable cases. Information about the clinical course and prognostic factors of CSU in this study could help physicians predict the prognosis of patients and ensure medication adherence of patients with CSU .
STANDARDS AND LICENSURE IN OPHTHALMOLOGY
Authors: WILLIAM H. CRISP
Journal: JAMA (1933)

Few would deny Emerson's pronouncement that "The first wealth is health." So essential to human happiness and prosperity is health and the normal functioning of the senses that it may be doubted whether any other profession carries so sacred a responsibility as that of the physician. In no walk of life is the combination of high intelligence with thorough training so necessary as in the practice of medicine. A man with either mediocre intelligence or inadequate training is likely to commit fatal errors of judgment or execution, and, even though poor standards are excused in other occupations, they should be rigidly excluded as regards those whose duty it is to protect or restore the health of the body or its members. The physician is interested in medical standards from two points of view: for the protection of the public and for the protection of the physician himself. The physician is
TCT-85 Factors Influencing Stent Recoil and Underexpansion In Vivo Independent of Atherosclerosis: A Multimodality Imaging Study in Normal Porcine Coronary Arteries
Authors: Masahiko Shibuya, Carlos A. Gongora, Yanping Cheng, Gerard B. Conditt, Jenn McGregor, Juan Granada, Greg L. Kaluza
Journal: Journal of the American College of Cardiology (2014)
PROBLEMS IN FEEDING SCHOOL CHILDREN.
Authors: HORACE P. MAKECHNIE
Journal: JAMA (1898)

When the plebeians had seceded from Rome, the story of the stomach and members was related as an inducement for them to return. Today we need to have the story retold and our attention called anew to the importance of the stomach as related to all the other organs. So far as our school children are concerned, our physicians are well aware of the facts, which therefore need not be demonstrated. Many years ago, while teaching, I noticed that quite a percentage of children who had been sent to school very young and had been kept there continually became very dull. They would not study nor learn as bright active children ought. I used to say they were school hardened. Since I have practiced medicine I have been consulted by quite a number of school children who had dyspepsia which was due to a lack of nourishment. What! starvation around
The incidence of immune thrombocytopenic purpura in children and adults: A critical review of published reports
Authors: Deirdra R. Terrell, Laura A. Beebe, Sara K. Vesely, Barbara R. Neas, Jodi B. Segal, James N. George
Journal: American Journal of Hematology (2009)

Reports of the incidence of ITP are few and their methodology is variable. Accurate estimates of the incidence of immune thrombocytopenic purpura (ITP) are important to understand the medical and public health impact of the disease. To critically review all published reports on the incidence of ITP in children and adults, all articles identified on the Medline database (searched January 1, 1966-August 7, 2009) that reported data on the incidence of ITP were retrieved. Articles which directly estimated the incidence of ITP were selected for review. Eight articles reported the incidence of acute ITP in children. After review, four were determined to have the strongest estimates, based on the method of patient identification and study design. The lowest incidence estimate in these four studies was 2.2 per 10(5) children/year (95% confidence interval 1.9, 2.4) and the highest incidence estimate was 5.3 per 10(5) children/year (95% confidence interval 4.3, 6.4). Three studies reported the incidence of ITP in adults. The estimate from the article with the strongest methodology reported an incidence estimate of 3.3 per 10(5) adults/year. The current strongest estimate of the incidence of acute ITP in children is between 1.9 and 6.4 per 10(5) children/year; for adults the current strongest estimate of the incidence of ITP is 3.3 per 10(5) adults/year. An important limitation of these studies is that they are primarily from Europe and may not be generalizable to all regions.
An Outline for the Treatment of Severe Burns
Authors: Stanley M. Levenson, Ross W. Green, Charles C. Lund
Journal: New England Journal of Medicine (1946)

AT THE end of a three-year study of burns at the Boston City Hospital, the following outline of directions for their care has been prepared for the guidance of the hospital staff. This outline has been available at the hospital since July 1, 1945.Duties of the Accident-Floor PersonnelTake temperature, pulse, blood pressure and respiration. Remove clothing and place patient on sterile sheet. Cover with sterile sheet.Inspect area of burn and plot on a Boston City Hospital Burn Diagram.1 Fill out diagram and make careful estimate of area burned. Order a normal dose of morphine if patient is . . .
O 4 Enhancement of buccal drug delivery in-vitro and in-vivo
Authors: A.J. Hoogstraate, J. Verhoef, B. Tuk, A. Pijpers, L.A.M.G. van Leengoed, J.H.M. Verheijden, H.E. Junginger, H.E. Boddé
Journal: Journal of Controlled Release (1996)
Endovascular aneurysm repair
Authors: M M Thompson, R D Sayers, R F Bell
Journal: BMJ (1997)

In the past decade open surgical procedures have been partly replaced by the widespread introduction of laparoscopic and endoscopic techniques. Similar changes have affected vascular surgery, with the development of percutaneous transluminal angioplasty for peripheral atherosclerotic disease. Until recently, the treatment of abdominal aneurysms had relied solely on surgical exposure of the aneurysm and direct graft replacement. However, the recent advent of endovascular aortic aneurysm repair has offered an alternative to conventional surgical practice.1 This new technique has been enthusiastically endorsed by vascular surgeons worldwide,2 3 but, as yet, little proof has been offered to support its widespread introduction.

Endovascular aneurysm repair involves the transfemoral or transiliac placement of a endograft within the aneurysm, with the aim of completely excluding the aneurysm sac from the circulation. The endograft is anchored in place by self expanding or balloon expandable stents, which may support all or part of the graft. The advantages of this technique …
CHEMICAL ASPECTS OF HAIR LOSS AND ITS COSMETOLOGICAL SIGNIFICANCE
Authors: F.A.J. Thiele
Journal: British Journal of Dermatology (1975)

Journal Article CHEMICAL ASPECTS OF HAIR LOSS AND ITS COSMETOLOGICAL SIGNIFICANCE Get access F.A.J. Thiele F.A.J. Thiele Department of Dermatology, University of Nijmegen, Nijmegen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 92, Issue 3, 1 March 1975, Pages 355–359, https://doi.org/10.1111/j.1365-2133.1975.tb03089.x Published: 01 March 1975
Ectopic expression of the calcium-binding protein parvalbumin in mouse liver endothelial cells
Authors: M B Castillo, M W Berchtold, T Rulicke, B Schwaller, V Gotzos, M Pinzani, J Reichen, M R Celio
Journal: Hepatology (1997)

To elucidate the physiological role of the Ca 2+ binding protein parvalbumin, we have generated transgenic mice carrying the full-length complementary DNA (cDNA) of rat parvalbumin under the control of the heavy-metal inducible metallothionein IIA promoter. Immunohistochemical and biochemical methods have been used to detect the presence of ectopic parvalbumin expression in different tissues. Here we show the expression of parvalbumin in endothelial cells lining the liver sinusoids in situ and after isolation in vitro. The hemodynamic effects of endothelin 1, a peptide hormone mediating potent vasoconstriction via calcium signalling, were investigated in the mouse liver perfused in situ. Vasoconstriction, thought to be mediated by the Ito cell, was not affected in the transgenic animals, whereas microvascular exchange, probed with the multiple indicator dilution technique, was markedly decreased in normal mice but virtually not affected in the transgenic animals. This suggests that ectopically expressed parvalbumin is involved in the regulation of Ca 2+ signals in the sinusoidal endothelial cells. This animal model could be of interest to those working on the physiology of liver circulation.
Resection of Head of Pancreas and Duodenum for Carcinoma--Pancreatoduodenectomy
Authors: A. Brunschwig
Journal: CA A Cancer Journal for Clinicians (1974)

CA: A Cancer Journal for Clinicians publishes information about the prevention, early detection, and treatment of cancer, as well as nutrition, palliative care, survivorship, and additional topics of interest related to cancer care.
Duodenal nonheme iron content correlates with iron stores in mice, but the relationship is altered by Hfe gene knock-out
Authors: Robert J. Simpson, Edward S. Debnam, Abas H. Laftah, Nita Solanky, Nick Beaumont, Seiamak Bahram, Klaus Schümann, S. Kaila S. Srai
Journal: Blood (2003)
Yaws in Massachusetts
Authors: John G. Downing
Journal: New England Journal of Medicine (1948)

YAWS can occur in Massachusetts. Several physicians refused to believe this possibility and doubted the history given on several occasions by the mother of the patients in the cases reported below. The return of overseas veterans and the rapidity of transportation increase the likelihood of sporadic cases of tropical diseases. A carefully taken history, including recent change of abode, is important. The diagnosis in both these cases was promptly made by the original observers in Jamaica.Ease of transmission, owing to abundance of the etiologic agent on the exposed skin, makes yaws a serious disease in crowded neighborhoods. It must . . .
InSync Italian Registry: Biventricular stimulation in patients with heart failure. Does atrial fibrillation result in differing patients response at follow‐up?
Authors: Maurizio Mangiavacchi, Maurizio Gasparini, Edoardo Gronda, Massimo Mantica, Bruno Andreuzzi, Paola Galimberti, Ferdinando Coltorti, Ilaria Vivini, Sergio Cavaglià
Journal: European Journal of Heart Failure (2000)
Bed Rest in the Treatment of Pulmonary Tuberculosis
Authors: Albert I. DeFriez, William E. Patton, Edward J. Welch, Theodore L. Badger
Journal: New England Journal of Medicine (1954)

THIS is a study of bed rest in the treatment of pulmonary tuberculosis and its effect on the incidence of relapse as seen in the late follow-up study of patients. It is an analysis of the effect of strict bed rest on tuberculosis. It is a follow-up report of the over-all sanatorium care of tuberculosis. It presents the end results of strict bed-rest treatment in conjunction with temporary and permanent collapse procedures completed before the advent of modern chemotherapy.BackgroundRecent advances in the treatment of pulmonary tuberculosis warrant a critical review of the place of bed rest in the . . .
In vitro behavior of a porous TiO2/perlite composite and its surface modification with fibronectin
Authors: Matthias von Walter, Matthias Rüger, Christian Ragoß, Guy C.M. Steffens, Dirk A. Hollander, Othmar Paar, Horst R. Maier, Willi Jahnen-Dechent, Anja K. Bosserhoff, Hans-Josef Erli
Journal: Biomaterials (2004)
The Circulating Medical Article.
Authors: W. A. Pusey
Journal: JAMA (1904)

Chicago, March 14, 1904.  To the Editor:  —Apropos of your editorial on The Circulating Medical Article (The Journal, March 12, 1904, p. 716), the following letter from Professor Finsen is of interest. It is in reply to a letter from me calling attention to the way in which his name and the reputation of his institute are being misused in this country:  Kopenhagen, Feb. 2, 1904.  Professor Dr. Wm. Allen Pusey.  Dear Sir:  —Thanking you for your letter, I can not but highly regret the abuse which is made of my name. I have not the least to do with the matter, which you speak of in your letter, and there are nowhere branches of the Finsen Light Institute, consequently in America neither.  On the other hand, I am hospitable to all physicians,.... but as you understand it is impossible to me to control the people and to know whether
The 2010 Paul Janssen Award recognizes achievement in AIDS research
Authors: Kathryn Claiborn
Journal: Journal of Clinical Investigation (2010)

On September 8, Johnson & Johnson awarded the 2010 Dr. Paul Janssen Award for Biomedical Research to Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases at the NIH, and Erik De Clercq, professor emeritus at the Rega Institute for Medical Research in Belgium (Figure ​(Figure1),1), in recognition of their work on HIV and AIDS. Named for physician and chemist Paul Janssen, known affectionately as Dr. Paul, the award honors active scientists who have made contributions to the improvement of human health. The JCI recently spoke to Fauci and De Clercq about the award, their careers, and the future of AIDS research.
Long-Term Nitroglycerin Treatment Is Associated With Supersensitivity to Vasoconstrictors in Men With Stable Coronary Artery Disease: Prevention by Concomitant Treatment With Captopril
Authors: Thomas Heitzer, Hanjörg Just, Carsten Brockhoff, Thomas Meinertz, Manfred Olschewski, Thomas Münzel
Journal: Journal of the American College of Cardiology (1998)