tbuckley/cabot-search huggingface dataset:
Preclinical Evidence that Use of TRAIL in Ewing's Sarcoma and Osteosarcoma Therapy Inhibits Tumor Growth, Prevents Osteolysis, and Increases Animal Survival
Authors: Gaëlle Picarda, François Lamoureux, Loïc Geffroy, Pascal Delepine, Tristan Montier, Karine Laud, Franck Tirode, Olivier Delattre, Dominique Heymann, Françoise Rédini
Journal: Clinical Cancer Research (2010)

Osteosarcoma and Ewing's sarcoma are high-grade neoplasms typically arising in the bones of children and adolescents. Despite improvement in therapy, the five-year survival rate is only 20% for patients not responding to treatment or presenting with metastases. Among new therapeutic strategies, the efficacy of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily with strong antitumoral activity and minimal toxicity to most normal cells and tissues, was investigated by complementary approaches both in vitro and in preclinical models.The sensitivity of osteosarcoma and Ewing's sarcoma cell lines to TRAIL was investigated in vitro by determining TRAIL receptor expression together with TRAIL effects on cell viability and apoptosis. Complementary preclinical studies were carried out in respective tumor models by inoculation of osteosarcoma or Ewing's sarcoma tumor cells in paraosseous location. In addition, a model of lung nodule dissemination was developed by i.v. injection of osteosarcoma cells.In vitro, both osteosarcoma and Ewing's sarcoma cells that express the TRAIL death receptors were highly sensitive to TRAIL-induced caspase-8-mediated apoptosis. TRAIL administered in vivo by nonviral gene therapy inhibited primary bone tumor incidence and growth by 87% and prevented tumor-induced osteolysis, leading to a significant 2-fold increase in animal survival 40 days after tumor induction. Furthermore, TRAIL inhibited tumor nodule dissemination in lungs and increased survival in an osteosarcoma model.These findings suggest that TRAIL is a promising candidate for the development of new therapeutic strategies in the most frequent malignant primary bone tumors.
Herpes Zoster, Postherpetic Neuralgia, and Interferon-Gamma
Authors: KENSUKE USUKI
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 April 1988Herpes Zoster, Postherpetic Neuralgia, and Interferon-GammaKENSUKE USUKI, M.D., KIYOSHI KITAMURA, M.D., ALIO URABE, M.D., FUMIMARO TAKAKU, M.D.KENSUKE USUKI, M.D.Search for more papers by this author, KIYOSHI KITAMURA, M.D.Search for more papers by this author, ALIO URABE, M.D.Search for more papers by this author, FUMIMARO TAKAKU, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-4-643_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We report one case of herpes zoster and two cases of postherpetic neuralgia successfully treated with recombinant human interferon-gamma.A 16-year-old girl with Weber-Christian disease had been treated with corticosteroids and cyclosporin A. In March 1987, small, painful vesicles appeared in the right lateral femoral and gluteal regions corresponding to the distribution of the right S-2. Three days later, 2 X 106units of interferon-gamma was administered subcutaneously into the lesions. Within 3 hours, the pain in the injected area had subsided. However, new vesicles accompanied by pain appeared later, which were subsequently treated with 2 X...References1. FELDMAN S, CHAUNDARY S, OSSI M, and EPP E. A viremic phase for herpes zoster in children with cancer. J Pediatr. 1977;91:597-600. CrossrefMedlineGoogle Scholar2. MERIGAN T, RAND K, POLLARD R, ABDALLAH P, JORDAN G, and FRIEND R. Human leukocyte interferon for the treatment of herpes zoster in patients with cancer. N Engl J Med. 1987;298:981-7. CrossrefGoogle Scholar3. MERIGAN T, GALLAGHER J, POLLARD R, and ARVIN A. Short-course human leukocyte interferon in treatment of herpes zoster in patients with cancer. Antimicrob Agent Chemother. 1981;19:193-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: KENSUKE USUKI, M.D.; KIYOSHI KITAMURA, M.D.; ALIO URABE, M.D.; FUMIMARO TAKAKU, M.D.Affiliations: University of Tokyo Tokyo 113, Japan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOff-label uses of biologics in dermatology: Interferon and intravenous immunoglobulin (Part 1 of 2)Recombinant Interferon-Gamma (rIFN-gamma) in Dermatology 1 April 1988Volume 108, Issue 4Page: 643-644KeywordsLesionsVesicles ePublished: 1 December 2008 Issue Published: 1 April 1988 PDF downloadLoading ...
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I
Authors: Edward T Chouchani, Carmen Methner, Sergiy M Nadtochiy, Angela Logan, Victoria R Pell, Shujing Ding, Andrew M James, Helena M Cochemé, Johannes Reinhold, Kathryn S Lilley, Linda Partridge, Ian M Fearnley, Alan J Robinson, Richard C Hartley, Robin A J Smith, Thomas Krieg, Paul S Brookes, Michael P Murphy
Journal: Nature Medicine (2013)
1059-12 Sustained upregulation of inflammatory cytokine and its receptor genes associated with proteinase activation in abdominal aortic aneurysm: Results from combined study with cDNA array and real-time reverse transcriptase polymerase chain reaction methods
Authors: Takeo Higashikata, Masakazu Yamagishi, Hiroaki Sasaki, Kenji Minatoya, Hitoshi Ogino, Hatsue Ishibashi-Ueda, Aiji Sakamoto, Hitonobu Tomoike
Journal: Journal of the American College of Cardiology (2004)
Characterization of Noncalcified Coronary Plaques and Identification of Culprit Lesions in Patients With Acute Coronary Syndrome by 64-Slice Computed Tomography
Authors: Toshiro Kitagawa, Hideya Yamamoto, Jun Horiguchi, Norihiko Ohhashi, Futoshi Tadehara, Tomoki Shokawa, Yoshihiro Dohi, Eiji Kunita, Hiroto Utsunomiya, Nobuoki Kohno, Yasuki Kihara
Journal: JACC. Cardiovascular imaging (2009)
TCT-591 Biological Efficacy and Vessel Healing of Second Generation Paclitaxel Coated Balloons: A Comparative Study with the original PACCOCATH Technology in the Ilio-Femoral In-Stent Restenosis Model in the Familial Hypercholesterolemic Swine
Authors: Piotr Buszman, Armando Tellez, Maxwell Afari, Jenn McGregor, Yanping Cheng, Gerard Conditt, Serge Rousselle, Greg Kaluza, Juan Granada
Journal: Journal of the American College of Cardiology (2012)
The problems of controlling controlled drugs
Authors: Des Spence
Journal: BMJ (2010)

Medicine has endured much regulation and intervention: now even teachers look at us with sympathy. This regulation takes the form of annual appraisals (and of course revalidation, when it arrives in 2050) and new contracts that dictate much of our day to day activity—medical micromanagement. Professionalism is mistrusted. Perhaps we have only ourselves to blame, and perhaps this is all in the best interest of patients.

One area now more closely regulated is controlled drugs. Many general practitioners once carried one or two vials of diamorphine, which was given very occasionally on …
<scp>l</scp> -Arginine Transport in the Human Coronary and Peripheral Circulation
Authors: S.E.S. Miner, A. Al-Hesayen, S. Kelly, T. Benson, J.J. Thiessen, V.R. Young, J.D. Parker
Journal: Circulation (2004)

Nitric oxide synthase (NOS) uses arginine for the production of nitric oxide (NO). High intracellular concentrations of arginine suggest that NOS activity should be independent of plasma arginine supply. However, under certain conditions, increased plasma arginine concentrations appear to be associated with increased NOS activity. The purpose of this study was to explore arginine transport within the human coronary and peripheral circulationMass-labeled 15N2-arginine was infused to steady state before cardiac catheterization in 31 patients. After diagnostic angiography, a catheter was placed in the coronary sinus. The transcardiac concentration gradient (aorta-coronary sinus) of 15N2-arginine was used as a measure of arginine transport at baseline and during infusions of acetylcholine and N(G)-monomethyl-L-arginine (L-NMMA). No gradient was detected at rest. During the infusion of acetylcholine, a significant gradient was detected (2.5+/-1.2 micromol/L, P=0.01) corresponding to a fractional extraction of 11.7+/-7.5%. This is consistent with in vitro studies that suggest that stimulation of NOS induces arginine transport. During the infusion of L-NMMA, the concentration of 15N2-arginine increased in the coronary sinus, producing a gradient of -3.9+/-1.3 micromol/L (P=0.0002), corresponding to a fractional production of 20.5+/-5.0%. This is consistent with in vitro studies that suggest that L-NMMA induces the efflux of arginine from the cell to the extracellular space via transporter-mediated transstimulation.The use of steady-state 15N2-arginine to examine transorgan L-arginine gradients represents a novel tool for the study of L-arginine transport and the mechanisms of endothelial and NOS dysfunction.
Rhymes to Meet Snakes By
Authors: Christine F. Wurstlin
Journal: JAMA (1988)

<h3>To the Editor.</h3> —A poem on display in a Nairobi, Kenya, nature museum provides a simple method for differentiating poisonous from nonpoisonous snakes bearing red, yellow, and black bands. It reads as follows: "Red and yellow kill a fellow/Red and black, venom lack." The accompanying explanation states that if the red and yellow bands are in contact, the snake is poisonous. Adjacent red and black bands identify its nonpoisonous cousin. While I do not know if this is true throughout the world, it certainly applies to the identification of the Eastern coral and scarlet king snakes.<sup>1</sup>
LEFT VENTRICULAR RELAXATION IS IMPAIRED IN SUBJECTS WITH LV CONCENTRIC REMODELING
Authors: Yuri Ozaki, Masatoshi Kawana, Ken Shimamoto, Fujio Tatsumi, Haruki Sekiguchi, Yufuko Takahashi, Mika Shimizu, Mika Shimizu
Journal: Journal of the American College of Cardiology (2013)
Management of Chronic Renal Failure
Authors: Norman G. Levinsky
Journal: New England Journal of Medicine (1964)

These discussions are selected from the weekly staff conferences in the Department of Medicine, University of California Medical Center, San Francisco. Taken from transcriptions, they are prepared by Drs. Martin J. Cline and Hibbard E Williams, Assistant Professors of Medicine, under the direction of Dr. Lloyd H. Smith, Jr., Professor of Medicine and Chairman of the Department of Medicine.
Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras
Authors: Lee Adam Wheeler, Radiana Trifonova, Vladimir Vrbanac, Emre Basar, Shannon McKernan, Zhan Xu, Edward Seung, Maud Deruaz, Tim Dudek, Jon Ivar Einarsson, Linda Yang, Todd M. Allen, Andrew D. Luster, Andrew M. Tager, Derek M. Dykxhoorn, Judy Lieberman
Journal: Journal of Clinical Investigation (2011)

The continued spread of the HIV epidemic underscores the need to interrupt transmission. One attractive strategy is a topical vaginal microbicide. Sexual transmission of herpes simplex virus type 2 (HSV-2) in mice can be inhibited by intravaginal siRNA application. To overcome the challenges of knocking down gene expression in immune cells susceptible to HIV infection, we used chimeric RNAs composed of an aptamer fused to an siRNA for targeted gene knockdown in cells bearing an aptamer-binding receptor. Here, we showed that CD4 aptamer-siRNA chimeras (CD4-AsiCs) specifically suppress gene expression in CD4⁺ T cells and macrophages in vitro, in polarized cervicovaginal tissue explants, and in the female genital tract of humanized mice. CD4-AsiCs do not activate lymphocytes or stimulate innate immunity. CD4-AsiCs that knock down HIV genes and/or CCR5 inhibited HIV infection in vitro and in tissue explants. When applied intravaginally to humanized mice, CD4-AsiCs protected against HIV vaginal transmission. Thus, CD4-AsiCs could be used as the active ingredient of a microbicide to prevent HIV sexual transmission.
Reversal of chronic hypoxia-induced alterations in pulmonary artery smooth muscle electromechanical coupling upon air breathing
Authors: Sébastien Bonnet, Eric Dubuis, Christophe Vandier, Stéphanie Martin, Roger Marthan, Jean-Pierre Savineau
Journal: Cardiovascular Research (2002)

Objective: Chronic hypoxia (CH) induces selective pulmonary hypertension which is accompanied by structural and functional alterations in the pulmonary vasculature. Little information is available on the regression of CH-induced functional alterations of pulmonary wall. In the present work, we investigated the reversal of CH-induced pulmonary hypertension with a special focus on alterations in the electrophysiological properties of pulmonary artery smooth muscle cells (PAMCs) after normoxia recovery. Methods: Rats were exposed to a hypobaric environment for 3 weeks (CH rats) and then subjected to a normoxic environment for 3 weeks (normoxia-recovery group) and compared with rats maintained in a normoxic environment (control rats). Electrophysiological properties of PAMCs were studied using conventional microelectrodes and patch-clamp technique. Results: CH rats exhibited a threefold increase in pulmonary blood pressure compared to control rats and this increase was fully reversed following 3 weeks of normoxia. PAMCs from CH rats were depolarised (about 20 mV), had an elevated calcium concentration and exhibited a hypersensitivity to 4-aminopyridine (4-AP) of membrane potential as well as the tone of arterial rings compared with tissues from control rats. Whole cell patch-clamp recordings indicated that voltage gated potassium channel currents IKv and IK(N) were decreased in PAMCs from CH rats with a hyper sensitivity of IK(N) to 4-AP. CH-induced alterations in electrophysiological properties of PAMCs were also fully reversed after 3 weeks of normoxia recovery. Conclusions: Both the increase in the pulmonary blood pressure and alterations in electrophysiological properties of PASMCs simultaneously reverse after normoxia recovery. This complete reversibility of all of the CH-induced pulmonary vascular alterations suggests that curative treatments for PAHT may now be designed aimed at targeting the very limited key factors implicated in hypoxia sensing.
A Text-book of X-ray Diagnosis by British Authors, vol 2: Cardiovascular System
Authors: Marvin L. Daves
Journal: JAMA (1973)

This venerable reference text first appeared in 1938 and was last revised in 1957. The list of contributors is long and impressive but the form and substance of the work are still largely attributable to the prestigious editors. Readers who enjoy sharing the experiences of an authority will find the editors'<i>ipse dixit</i>style more gratifying than those of us who prefer the cold scientific approach and an up-to-date bibliography. The index says "Part One," but the expanded cardiovascular system now comprises the entire volume. Worthwhile revisions and additions are mainly in the chapters on congenital heart disease, the great vessels, and special procedures. Some chapters are unretouched despite important interim developments. For instance, perpetuating the fallacy that myocardial dilatation can be distinguished from pericardial effusion by a positional change in cardiac shape is an academic misdemeanor, but failing to mention the accurate differentiation possible by ultrasound or blood pool
Reuse of haemodialysis equipment: convenience and cost effectiveness.
Authors: H K Banester, R D Driscoll, R N Greenwood, W R Cattell
Journal: BMJ (1982)

The shortage of resources for providing renal replacement makes it essential to reduce revenue costs wherever possible. Assuming that haemodialysis is likely to remain a mainstay of renal replacement, a policy of reusing the expensive disposable dialysers and blood lines could offer substantial cost savings. Such reuse has been shown to be safe and to maintain efficiency, but it must also take account of convenience to the patient, especially those dialysing at home. A survey of patients treated with home dialysis shows that the rate of reuse of the complete extracorporeal circuit was highest for those patients who had automated reuse systems.
Dietary factors in carcinoma of the stomach: A study of 100 cases and 200 controls
Authors: E. D. Acheson, R. Doll
Journal: Gut (1964)

EDITORIAL SYNOPSIS The declining mortality from carcinoma of the stomach in western countries and the big variations in incidence between countries makes it likely that there are environmental factors concerned in this disease.This study is an attempt to define dietary differences but no convincing differences of probable aetiological importance were discovered.
Excision of a Choledochal Cyst
Authors: Henry J. Heimlich
Journal: JAMA (1963)

In a 31-year-old woman a congenital choledochal cyst that replaced the entire common bile duct was completely excised and the duct replaced by a gastric pedicle tube constructed from the greater curvature of the stomach and nourished by the right gastroepiploic vessels. The patient is completely well, 18 months after the operation. This gastric pedicle tube operation, done for the first time on a patient with a benign obstruction of the bile ducts, has the following advantages: (1) The greater curvature of the stomach is readily accessible and the duodenum need not be mobilized; (2) the gastric pedicle tube can be made any reasonable length and diameter by virtue of its excellent blood supply from the gastroepiploic vessels; and (3) bile passes through the duodenum, whereas in a choledochojejunostomy the duodenum is by-passed and peptic ulceration can result.
Pulmonary Alveolar Proteinosis Xe-133 Scintigraphic Findings Before and After Bronchopulmonary Lavage
Authors: JUN-ICHI MURAYAMA, KIYOSHI FUKUDA, TETSUO SATO, HEIICHI YANO, MORIO OHTSUKA, YASUYUKI YOSHIZAWA, SHIZUO HASEGAWA
Journal: Clinical Nuclear Medicine (1993)

A 44-year-old woman with pulmonary alveolar proteinosis was treated by repeated unilateral bronchopulmonary lavages over 6.5 years. The effectiveness of the treatment was assessed by Xe-133 scintigraphy as well as lung function tests and chest roentgenograms. Xe-133 scintigraphy clearly demonstrated improvement of regional ventilation and perfusion, and equalization of the ventilation and perfusion ratio. Therefore, Xe-133 scintigraphy was found to be useful in the analysis of changes in regional aeration, ventilation, and perfusion before and after bronchopulmonary lavage in pulmonary alveolar proteinosis.
Waldenström macroglobulinemia terminating in acute leukemia: A report of three cases
Authors: Douglas E. Horsman, Robert T. Card, Leo F. Skinnider
Journal: American Journal of Hematology (1983)

Abstract Acute leukemia was observed to develop in three patients with Waldenstöm marcroglobulinemia. Each patient had been treated with cytotoxic drug therapy. Pancytopenia preceded the onset of the terminal leukemia in two of the three cases. The acute leukemias were all of acute myelogenous type. All of the patients died soon after the development of the terminal leukemia. A number of recent reports have documented acute terminal leukemia in patients with macroglobulinemias and multiple myeloma, as well as other malignant and nonmalignant diseases. The role of the cytotoxic drugs, especially chlorambucil, cyclophosphamide, and melhalan, in leukemogenesis has been raised by these recent reports.
THE MODIFIED PNEUMOCOCCUS VACCINE OF ROSENOW
Authors: E. C. Rosenow
Journal: JAMA (1922)

<h3>To the Editor:</h3> —While a member of the John McCormick Institute for Infectious Diseases, Chicago, I discovered that antibodies appear more rapidly in the blood following the injection of partially autolyzed pneumococci ("pneumococcus antigen") than following the injection of heat-killed pneumococci. Through the cooperation of Dr. Ludvig Hektoen, director of the institute, and of physicians at the Presbyterian and Cook County hospitals, the effect of this antigen on the course of lobar pneumonia, as compared with alternate untreated cases, was studied for three consecutive years. The mortality rate was lower in the treated than in the control series. Subsequent studies have corroborated these results. During my studies on the bacteriology of influenza in 1918-1919, I prepared, from the freshly isolated strains of bacteria, mixed vaccines which appeared to be valuable in prophylactic inoculation against the more serious respiratory infections in influenza. The burden of the preparation and distribution of these
Coronary Bypass for Stable Angina
Authors: Frank E. Kloster, E. Louise Kremkau, Leonard W. Ritzmann, Shahbudin H. Rahimtoola, Josef Rösch, Paula H. Kanarek
Journal: New England Journal of Medicine (1979)

To evaluate the effects of coronary-artery bypass, 100 patients with stable, disabling angina were randomized to medical (49) or surgical (51) therapy. There was no statistical difference in major cardiac events after three years (death in five medical vs. four surgical, infarction in eight vs. 10, and unstable angina requiring operation or reoperation in eight vs. three cases). Surgical patients with three-vessel disease had fewer major events (P<0.05) than the comparable medical group and less unstable angina requiring operation (P<0.02). All unstable angina was less frequent in the surgical group (15 vs. six, P<0.01). Functional classification improved more in surgical patients at six months (P<0.01) and at late follow-up examination (P<0.05). After six months, surgical patients achieved significantly higher exercise work loads (P<0.01), exercise heart rates (P<0.05), maximum paced heart rates (P<0.01) and myocardial lactate extraction (P<0.01). On the basis of this interim report of a relatively small group of patients, we conclude that bypass results in greater functional improvement and less unstable angina than medical therapy. The likelihood of death and myocardial infarction is unchanged by operation. (N Engl J Med 300:149–157, 1979)
Development and validation of a computer program using Bayes's theorem to support diagnosis of rheumatic disorders.
Authors: H J Moens, J K van der Korst
Journal: Annals of the Rheumatic Diseases (1992)

A computer program has been developed to support the differential diagnosis of major rheumatic disease categories. Knowledge for the program was derived from the sensitivity and specificity of findings in a group of 1052 consecutive patients of a rheumatological outpatient clinic. Computer predictions based on two variations of Bayes9s theorem were compared with 9gold standard9 diagnoses in 570 test cases from the same clinic. The results demonstrate the feasibility of this approach, but also that refinements of both the method of calculation and the knowledge are required.
P1061 LONG-TERM TREATMENT WITH TENOFOVIR IN TREATMENT-NAIVE OR -EXPERIENCED CHB PATIENTS IS EFFECTIVE AND WELL TOLERATED IN REAL-LIFE PRACTICE: 3 YEARS RESULTS OF THE VIREAL STUDY
Authors: G.-P. Pageaux, F. Zoulim, X. Causse, D. Larrey, D. Ouzan, R. Truchi, A. Pauwels, D. Guyader, V. De Ledinghen, J.-P. Zarski, J.-F. Cadranel, V. Tilliet, C. Stern, O. Libert, P. Marcellin
Journal: Journal of Hepatology (2014)