tbuckley/cabot-search huggingface dataset:
Mildly dilated congestive cardiomyopathy. Use of prospective diagnostic criteria and description of the clinical course without heart transplantation.
Authors: A Keren, S Gottlieb, D Tzivoni, S Stern, R Yarom, M E Billingham, R L Popp
Journal: Circulation (1990)

Prognosis in classically described dilated congestive cardiomyopathy has been reported to be related to ventricular size. Mildly dilated congestive cardiomyopathy (MDCM) has been defined as end-stage heart failure of unknown etiology (New York Heart Association class IV, left ventricular ejection fraction less than 30%), occurring with neither typical hemodynamic signs of restrictive myopathy nor significant ventricular dilatation (less than 15% above normal range). The present study includes follow-up in 12 nontransplant patients. In the first 4 months after diagnosis, two patients improved and are living, and two showed cardiac dilation and clinical deterioration and died. Six of the remaining eight with persistent MDCM died (four with intractable heart failure and two, sudden deaths) without change in ventricular size before death, despite medical therapy over 20 +/- 8 months. Eight comparable transplanted patients with persistent MDCM demonstrated improved total survival by life table analysis (p less than 0.05). A family history of congestive cardiomyopathy was found in nine of 16 patients (56%) with persistent MDCM. Nontransplant patients were older (p less than 0.02), but other findings were similar in the two groups. Endomyocardial biopsies available in 14 of 16 cases showed little or no myofibrillar loss in spite of severe hemodynamic impairment. The degree of myofibrillar loss did not correlate with hemodynamic parameters but showed good correlation with left ventricular size, that is, five of six patients with no myofibrillar loss had normal ventricular size, whereas all eight patients with mild myofibrillar loss had mild cardiomegaly (p less than 0.002). Our current experience suggests a somewhat variable but negative prognosis after prospective diagnosis of MDCM, with poor survival in patients with persistence of the original diagnostic features during follow-up. Preservation of heart size in MDCM is probably related to lack of significant myofibrillar loss. Thus, irrespective of heart size or myofibrillar preservation on biopsy, heart transplantation should be strongly considered in MDCM if signs of severe cardiac dysfunction persist despite therapy.
Atlas of Clinical Endocrinology Including Text of Diagnosis and Treatment
Authors: George F. Cahill
Journal: JAMA (1962)

This volume comes as a refreshing contrast to the numerous current publications emphasizing the biochemical basis of disease. The first edition of the<i>Atlas</i>was published 5 years ago, and the present volume contains essentially the same pictures of patients with classical endocrinopathies. Several new illustrations and syndromes, however, have been added; but more important, the recent developments in laboratory diagnostic techniques are appropriately included, such as determination of chromatin pattern and chromosomal counting. Likewise, the classical clinical references have been supplemented by the important articles appearing between 1955 and 1960. The value of the book, as the authors clearly describe in the preface, is in its pictorial presentation. No description of a cretin is as adequate as a simple photograph, and the same could be said for a patient with Cushing's syndrome. To have a classical photograph of the "typical" patient juxtaposed to a concise summary of the symptoms,
Reviews and Notes: Medicine and Western Civilization
Authors: Edward J. Huth
Journal: Annals of Internal Medicine (1996)

Literature of Medicine1 August 1996Reviews and Notes: Medicine and Western CivilizationEdward J. Huth, MDEdward J. Huth, MDUniversity of Pennsylvania, Philadelphia, PASearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-3-199608010-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail DJ Rothman, S Marcus, and SA Kiceluk; eds. 443 pages. New Brunswick, NJ: Rutgers Univ Pr; 1995. $22.95, paperback; $50.00, hardcover. ISBN 0-8135-2189-4. Order phone 800-446-9323.Few medical schools in the United States teach the history of medicine—no wonder! Why should medical history have a place within their walls? It would take time away from the marvels of molecular biology and the complex modern technology used in diagnosis and treatment. Even the proponents of medical history would probably concede its irrelevance to today's curriculum if it were to focus, as it often has, primarily on persons, dates, and places. How ... Author, Article, and Disclosure InformationAffiliations: University of Pennsylvania, Philadelphia, PA PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1996Volume 125, Issue 3Page: 255KeywordsAnesthesiaArrhythmiaHearingJewish peopleLumpectomyMolecular biologyResearch quality assessmentThyroid diseasesTuberculosis ePublished: 15 August 2000 Issue Published: 1 August 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The leukocyte migration inhibition test in allergic nickel contact dermatitis
Authors: T.M. MACLEOD, F. HUTCHINSON, E.J. RAFFLE
Journal: British Journal of Dermatology (1976)

No statistical difference was found between the migration indices of nickel sensitive and control subjects using the leukocyte migration inhibition test with two concentrations of nickel sulphate. The results contrast with the specific positive results demonstrated previously in the same subjects with the lymphocyte transformation test.
The Effects of Long-Term Oral Benfotiamine Supplementation on Peripheral Nerve Function and Inflammatory Markers in Patients With Type 1 Diabetes
Authors: David A. Fraser, Lien M. Diep, Inger Anette Hovden, Kristian B. Nilsen, Kari Anne Sveen, Ingebjørg Seljeflot, Kristian F. Hanssen
Journal: Diabetes Care (2012)

To study the effects of long-term oral benfotiamine supplementation on peripheral nerve function and soluble inflammatory markers in patients with type 1 diabetes.The study randomly assigned 67 patients with type 1 diabetes to receive 24-month benfotiamine (300 mg/day) or placebo supplementation. Peripheral nerve function and levels of soluble inflammatory variables were assessed at baseline and at 24 months.Fifty-nine patients completed the study. Marked increases in whole-blood concentrations of thiamine and thiamine diphosphate were found in the benfotiamine group (both P < 0.001 vs. placebo). However, no significant differences in changes in peripheral nerve function or soluble inflammatory biomarkers were observed between the groups.Our findings suggest that high-dose benfotiamine (300 mg/day) supplementation over 24 months has no significant effects upon peripheral nerve function or soluble markers of inflammation in patients with type 1 diabetes.
A Home-Based Intervention to Reduce Depressive Symptoms and Improve Quality of Life in Older African Americans
Authors: Laura N. Gitlin, Lynn Fields Harris, Megan C. McCoy, Nancy L. Chernett, Laura T. Pizzi, Eric Jutkowitz, Edward Hess, Walter W. Hauck
Journal: Annals of Internal Medicine (2013)

Effective care models for treating older African Americans with depressive symptoms are needed.To determine whether a home-based intervention alleviates depressive symptoms and improves quality of life in older African Americans.Parallel, randomized trial stratified by recruitment site. Interviewers assessing outcomes were blinded to treatment assignment. (ClinicalTrials.gov: NCT00511680).A senior center and participants' homes from 2008 to 2010.African Americans aged 55 years or older with depressive symptoms.A multicomponent, home-based intervention delivered by social workers or a wait-list control group that received the intervention at 4 months.Self-reported depression severity at 4 months (primary outcome) and depression knowledge, quality of life, behavioral activation, anxiety, function, and remission at 4 and 8 months.Of 208 participants (106 and 102 in the intervention and wait-list groups, respectively), 182 (89 and 93, respectively) completed 4 months and 160 (79 and 81, respectively) completed 8 months. At 4 months, participants in the intervention group showed reduced depression severity (difference in mean change in Patient Health Questionnaire-9 score from baseline, -2.9 [95% CI, -4.6 to -1.2]; difference in mean change in Center for Epidemiologic Studies Depression Scale score from baseline, -3.7 [CI, -5.4 to -2.1]); improved depression knowledge, quality of life, behavioral activation, and anxiety (P < 0.001); and improved function (P = 0.014) compared with wait-list participants. More intervention than wait-list participants entered remission at 4 months (43.8% vs. 26.9%). After treatment, control participants showed benefits similar in magnitude to those of participants in the initial intervention group. Those in the initial intervention group maintained benefits at 8 months.The study had a small sample, short duration, and differential withdrawal rate.A home-based intervention delivered by social workers could reduce depressive symptoms and enhance quality of life in most older African Americans.National Institute of Mental Health.
Familial Turner Syndrome
Authors: David A. Leichtman, Roy D. Schmickel, Thomas D. Gelehrter, Walter J. Judd, Margaret C. Woodbury, Karen L. Meilinger
Journal: Annals of Internal Medicine (1978)

Seven women in three generations of a family have been affected by Turner syndrome. Turner phenotype in this family is the result of deletion of the entire short arm of one X chromosome. The short arm deletion is transmitted by carriers of a balanced X-1 translocation. Autoradiographic findings showed that the deleted X chromosome was late labeling in those persons with Turner syndrome, whereas the normal X chromosome was late replicating in carriers of the balanced translocation. The results of Xga typing of erythrocytes suggest that the Xg locus is on the short arm of the X chromosome. Because of the clinical implications, we believe that families of persons with structural chromosomal abnormalities should be studied to exclude familial transmission.
Matrix metalloproteinase-7 expression in gastric carcinoma.
Authors: M Honda, M Mori, H Ueo, K Sugimachi, T Akiyoshi
Journal: Gut (1996)

BACKGROUND/AIMS: Matrix metalloproteinase-7 (MMP-7) belongs to the same family as matrix degrading metalloproteinase (MMPs) that may play an important part in cancer cell invasion and metastasis. This study reports on the MMP-7 mRNA expression level both in human gastric carcinomas and the normal gastric mucosa. METHODS: From fresh specimens of 47 surgical pairs of primary gastric carcinomas and corresponding normal tissue specimens, cDNA was obtained by reverse transcription (RT) and thereafter MMP-7 mRNAs were detected by means of a polymerase chain reaction. The tumour/normal (T/N) ratio of MMP-7 expression was calculated after correcting for glyceraldehyde-3-phosphate dehydrogenase as an internal control. RESULTS: The expression corrected levels of MMP-7 mRNA of the tumour was greater than that of the normal mucosa in 41 of 47 cases (87%). The 13 cases whose T/N ratio was more than 2.1 showed a deeper invasion of the gastric wall, and more frequent lymphatic or vascular permeations than the 34 cases whose T/N ratio was less than 2.0. An immunohistochemical study showed that MMP-7 was predominantly expressed in the cancer cells, weakly expressed in normal epithelial cells, and not expressed in the surrounding stromal cells. CONCLUSIONS: These findings suggest that the overexpression of MMP-7 may thus play an important part in tumour invasion in gastric carcinomas while, in addition, MMP-7 may also prove to be a useful marker for determining the biological aggressiveness of gastric carcinoma.
Cardiovascular Reactivity Among Surgeons: Not Music to Everyone's Ears
Authors: G. W. Stevenson, Steven C. Hall
Journal: JAMA (1995)

To the Editor.  —We read with interest the article by Drs Allen and Blascovich. 1 This article suggests that surgeon-selected music has  performance-enhancing effect. The surgeon participants in this report were studied in a soundproof hospital research laboratory. While we applaud enhanced stress reduction in surgeons, we question whether the operating theater is always an appropriate setting for this experience!  The practice of anesthesia has often been compared with  pilot's tasks during  transcontinental flight. Between takeoff and landing, there may be long periods, even hours, of tedious vigilance punctuated by moments of terror. Proper patient vigilance during anesthesia requires not only continuous visual inspection of patient and monitors but also filtration of multiple auditory signals, including auscultated heart tones, pulse oximetry tones, and multiple alarms (eg, inspired oxygen concentration, blood pressure, heart rate, respiratory rate, and tidal volume) and communications with the surgical and nursing staff. Communication
Endoscopic ultrasound-guided anterograde treatment of biliary stones following gastric bypass
Authors: F. Weilert, K. Binmoeller, F. Marson, Y. Bhat, J. Shah
Journal: Endoscopy (2011)

Endoscopic treatment of bile duct stones in gastric bypass patients is challenging. We describe a novel method involving endoscopic ultrasound (EUS)-guided anterograde interventions. After prior experience with EUS-guided rendezvous endoscopic retrograde cholangiopancreatography (ERCP) and direct EUS-guided anterograde stenting for malignant biliary obstruction, we have attempted EUS-guided treatment of biliary stones as first-line therapy following gastric bypass. Our approach involves: (i) EUS-fine needle aspiration (FNA) puncture into an intrahepatic bile duct; (ii) EUS-guided cholangiography; (iii) guide wire advancement across the ampulla; (iv) catheter dilation of the transhepatic-transgastric access tract; (v) anterograde balloon sphincteroplasty; and (vi) anterograde advancement of stones across the ampulla using a balloon catheter. We reviewed outcomes and complications of this technique. Six patients with previous Roux-en-Y gastric bypass were referred for treatment of symptomatic choledocholithiasis. EUS-guided transhepatic puncture and cholangiography was successful in 100 %, and revealed choledocholithiasis in all patients. Tract dilation, anterograde balloon sphincteroplasty, and stone extraction were successful in four (67 %). Anterograde sphincteroplasty failed in two patients due to inability to advance the transhepatic dilation catheters. In both cases, wires were advanced down the afferent limb, and rendezvous ERCP using double-balloon enteroscopy was successful. Five patients experienced no complications. One patient in whom EUS anterograde therapy failed due to difficulty in advancing the transhepatic dilation catheter, developed a subcapsular hepatic hematoma. This was managed conservatively. Direct EUS-guided treatment of biliary stones after gastric bypass appears safe and feasible. Further studies are needed to confirm the safety and efficacy of this technique.
Surgical Repair of the Partial Form of Persistent Common Atrioventricular Canal, with Special Reference to the Problem of Mitral Valve Incompetence
Authors: G. C. RASTELLI, WILLIAM H. WEIDMAN, JOHN W. KIRKLIN
Journal: Circulation (1965)

A total of 131 patients with the partial form of common atrioventricular canal were operated on between March, 1955 and January, 1964. The over-all hospital mortality rate was 3.8%; no deaths occurred in patients who had no or only mild incompetence of the mitral valve. Permanent heart block has not occurred in the last 93 cases. Results have been good in general, although there is evidence of residual mitral valve incompetence in many patients. In the few who had severe incompetence at the mitral valve before repair, the results have been considerably less satisfactory than in the group as a whole; therefore, further work is needed on this aspect of the problem.
Eosinophilic fascilitis with myelodysplasia responsive to treatment with cyclosporin
Authors: C.J. Flemming, P. Clarke, D. Kemmett
Journal: British Journal of Dermatology (1997)

Journal Article Eosinophilic fascilitis with myelodysplasia responsive to treatment with cyclosporin Get access C.J. Flemming, C.J. Flemming Department of Dermatology, Western Infirmary, Glasgow Search for other works by this author on: Oxford Academic Google Scholar P. Clarke, P. Clarke Department of Haematology, Vale of Leven Hospital, Alexandria, Scotland Search for other works by this author on: Oxford Academic Google Scholar D. Kemmett D. Kemmett Department of Dermatology, Western Infirmary, Glasgow Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 136, Issue 2, 1 February 1997, Pages 297–298, https://doi.org/10.1111/j.1365-2133.1997.tb14929.x Published: 01 February 1997
The treatment of mild hypertension study
Authors: E. B. Nelson
Journal: JAMA (1993)

To the Editor.  —The Treatment of Mild Hypertension Study (TOMHS) 1 represents a worthy contribution to the evaluation of therapeutic interventions on outcomes in patients with mild hypertension. The use of broad categories of morbidity and mortality outcomes demonstrated the overall benefit of antihypertensive agents plus lifestyle modification compared with lifestyle modification alone. Blood pressure reductions with  five antihypertensive agents (acebutolol, amlodipine maleate, chlorthalidone, doxazosin mesylate, and enalapril maleate) plus lifestyle modification were significantly greater than with lifestyle modification alone for all follow-up BP [blood pressure] measurements.  The significance of blood pressure reduction was also addressed in the accompanying Editorial 2 stating, All classes of drugs, with the exception of the angiotensin-converting enzyme inhibitor (enalapril), were equally effective in lowering blood pressure in TOMHS and  were superior to the lifestyle-modification regimen given with placebo. Clarification of this statement is needed because the drug dosages evaluated in TOMHS were
Short-Acting β-Blocker Administration in Patients With Septic Shock
Authors: Filippo Sanfilippo, Cristina Santonocito, Marc Oliver Maybauer
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pericardial Effusion in AIDS
Authors: Paul A. Heidenreich, Mark J. Eisenberg, Laura L. Kee, Carolyn A. Somelofski, Harry Hollander, Nelson B. Schiller, Melvin D. Cheitlin
Journal: Circulation (1995)

Background Although pericardial effusion is known to be common among patients infected with HIV, the incidence of pericardial effusion and its relation to survival have never been described. Methods and Results To evaluate the incidence of pericardial effusion and its relation to mortality in HIV-positive subjects, 601 echocardiograms were performed on 231 subjects recruited over a 5-year period (inception cohort: 59 subjects with asymptomatic HIV, 62 subjects with AIDS-related complex, and 74 subjects with AIDS; 21 HIV-negative healthy gay men; and 15 subjects with non-HIV end-stage medical illness). Echocardiograms were performed every 3 to 6 months (82% had follow-up studies). Sixteen subjects were diagnosed with effusions (prevalence of effusion for AIDS subjects entering the study was 5%). Thirteen subjects developed effusions during follow-up; 12 of these were subjects with AIDS (incidence, 11%/y). The majority of effusions (80%) were small and asymptomatic. The survival of AIDS subjects with effusions was significantly shorter (36% at 6 months) than survival for AIDS subjects without effusions (93% at 6 months). This shortened survival remained significant (relative risk, 2.2, P =.01) after adjustment for lead time bias and was independent of CD4 count and albumin level. Conclusions There is a high incidence of pericardial effusion in patients with AIDS, and the presence of an effusion is associated with shortened survival. The development of an effusion in the setting of HIV infection suggests end-stage HIV disease (AIDS).
489. Further Studies of the Most Efficient Vector Systems for Gene Transduction into Human Dendritic Cells Line (im-NMD)
Authors: Eigo Sato, Masanari Kato, Yuko Hara, Hua Yan, Tohko Miyagi, Xiao-Kang Li, Wataru Sugiura, Naoki Yamamoto, Kenichi Teramoto, Shigeki Arii, Hiromitsu Kimura
Journal: Molecular Therapy (2005)

It has become evident that the specialized antigen presenting cells (APC), dendritic cells (DC), play a pivotal role in initiating a primary immune response. Furthermore it has been reported that several systems including Adenoviral vector, HVJ-related vector, and electroporation, are able to transduce the gene into DC and are able to modify the function of DC in mouse and human. However, our previous study demonstrated this is not the case with rat DC. To our best knowledge, there has been no direct evidence to support that currently-used vector systems are able to effectively transduce the gene into DC. Inasmuch as most, if not all, DC or DC-related gene transfer studies appeared to be performed by employing heterogeneous cell population, it is important to determine the extent of gene transduction into bona fide DC. In this study, employing recently established human DC cell line called im-NMD and enhanced green fluorescence protein (EGFP : Clontec-C1), we further examined a relative efficiency of each vector system into one of the DC lineage cell line. We provide further evidence that none of the currently-used vector systems are able to sufficiently transfer the gene into human DC cell line. In particular when the im-NMD is so driven by several cytokine combinations such as Flt3/Flk2 ligand and IL-6, and/or IL-4 and TNFa that they became mature DC phenotypes, it is indeed the case. Nevertheless, the most efficient transduction of the EGFP gene was observed under a long-term culture of im-NMD cell line. Hence the successful gene transfer was observed after one week culturing only with HIV-based lentiviral vector system. It should be noted that HVJ vector system that contained FITC-tagged random primers were indeed incorporated into the im-NMD. Thus it suggested that there are mechanisms that interfere the exogenous gene expression in bona fide DC.