tbuckley/cabot-search huggingface dataset:
Socio-Medical Inquiries: Recollections, Reflections, and Reconsiderations
Authors: Rose Laub Coser
Journal: JAMA (1985)

This is a fine book—a must for sociologists and physicians alike, and for everyone who deals with issues of health and disease. It is persuasive in its claim that the medical profession, along with everyone else, has ignored social relations and feelings, yes, the very essence of being human. In our attempt to save lives and reduce suffering, we have ignored the elements that are difficult to deal with, such as interpersonal relationships on all levels, and have concentrated on technical aspects of illness, because those are the ones we can more easily handle. This book includes papers written during the last two decades. But it is far from being a simple collection of articles. The focus of the author's intellectual life is put in evidence by his own experiences. To mention only two, he had polio at age 12 years and was in a car accident four years later,
Maternal Brain Death During Pregnancy
Authors: Robert C. Goodlin
Journal: JAMA (1989)

To the Editor.—   find most worrying the statement by Field et al1that even a maternal refusal expressed before death does not, in itself, carry weight against the possibility of fetal survival. A similar thought process recently occurred in our nation's capitol. A 27-year-old married woman with a long history of cancer was dying of the disease in the 26th week of pregnancy. As reported inThe Lancet, when the court ordered a cesarean section the patient mouthed, I don't want it   don't want it done, and her obstetrician refused to operate. After an appeal to the judge, the surgery nevertheless was performed by another obstetrician on court order, and the nonviable fetus died 2 hours later. The mother subsequently died after 2 days. This was judged by Brahams2to be an appalling case.   believe that an obstetrician's primary obligations are to the mother
From the Museum: the Art of Thinking. Part Eight: Memory
Authors: Tom Kotsimbos
Journal: European Respiratory Journal (2014)

The Kiss is a resonating lyrical beacon for all art that consciously expresses the subconscious in contrast to art that is primarily sense-data driven. For Klimt “ all art is erotic ” and his Kiss embraces both the organismic union of male-female forms and the bold synthesis of artistic styles where two may be one in so many ways. Klimt's painting is so richly endowed with symbolic layering that nature is now being used rather than being obeyed or analysed. The perfect sensuality of a woman's face is wrapped in the protective adoration of her male lover's expressive hands. Both are oblivious to all around them. Highly stylised faces, hands and feet are painted to an extreme degree of beauty in figurative form whereas all remaining anatomy is draped in splendid fabric and the craftsmanship of the applied arts. The emotion of colour and the spirituality of composition complete the synthesis. The manrituality of composition complete the synthesis. The man's cloaked form is filled with erect squares and rectangles, while his lover's curvaceous lines are clothed in concentric circles and spirals. Arabesque lines, gold enriched ornament and art nouveau design maximally signify sexuality. The steadfast positioning of the couple on the edge of a flowering bed in the foreground is symbolically offset by the precipice-like fusion of earth and background next to them.
And what about the Chinese?
Authors: Heike Behrens, Michael Tomasello
Journal: Behavioral and Brain Sciences (1999)

We discuss other recent studies on the acquisition of the German plural that do not support the dual-mechanism model. The attested overgeneralizations are not by default only, nor completely random, but predictable from subregularities based on the grammatical gender and the phonology of the noun. In addition, the dual-mechanism model creates a number of problems for acquisition (theory) rather than solving existing ones.
Rheumatic and Nonrheumatic Valvular Heart Disease
Authors: Mohammed Rafique Essop, Vuyisile T. Nkomo
Journal: Circulation (2005)

Background— Unlike the Western world, valvular disease ranks among the major cardiovascular afflictions in Africa. Acute rheumatic fever and chronic rheumatic valvular disease in their most virulent form are still commonly encountered and impose a huge burden on limited healthcare resources. Methods and Results— We performed a systematic review of the literature with PubMed using rheumatic fever , rheumatic heart disease , valvular disease , warfarin anticoagulation , and pregnancy as search items. Literature emanating from Africa was emphasized. Epidemiology, current concepts on pathogenesis, and aspects of the medical and surgical management of this disease as seen from an African perspective are presented. The association of pregnancy with mitral stenosis is common and may be fatal if not managed appropriately. A practical approach to these patients is presented to optimize maternal and fetal outcome. Pregnant patients with mechanical valves require careful attention to ensure maternal survival and prevent fetal warfarin embryopathy. Prolonged subcutaneous heparin and frequent monitoring of the partial thromboplastin time are impractical in this setting, and the merits of different anticoagulation regimens are discussed. Congenital submitral aneurysms are a unique cause of mitral regurgitation, with the vast majority of cases originating from sub-Saharan Africa. Although the precise etiology is as yet unclear, the clinical and echocardiographic features are sufficiently characteristic to allow a preoperative diagnosis to be made. Transesophageal echocardiography allows much better definition of the size and anatomic relationships of the aneurysm. Surgical resection can be difficult but is usually curative. Mitral valve prolapse and endocarditis constitute the remaining frequent causes of valvular disease and are discussed briefly. Conclusions— The spectrum and presentation of valvular disease in Africa are uniquely different from elsewhere. Together with socioeconomic issues and the HIV pandemic, this fact makes it imperative that further epidemiological and clinical studies be undertaken and guidelines developed that are appropriate to the practice of medicine on the African continent.
Exertional Heatstroke in Novice Runners
Authors: Peter G. Hanson
Journal: JAMA (1979)

Heatstroke occurred in four apparently normal but inexperienced runners who were involved in road races of 10, 16, 32, and 42 km. Each of the runners attempted to increase his running pace by approximately 1 min/km during the last 5 km of the race. Symptoms of heatstroke occurred within five to ten minutes of the onset of increased effort. In three cases, environmental conditions (temperatures, 24 to 26 °C) were contributory. Specific guidelines and instructions are needed for inexperienced runners who enter distance road races. (<i>JAMA</i>242:154-157, 1979)
Differential effects of various fish proteins in altering body weight, adiposity, inflammatory status, and insulin sensitivity in high-fat–fed rats
Authors: Geneviève Pilon, Jérôme Ruzzin, Laurie-Eve Rioux, Charles Lavigne, Phillip J. White, Livar Frøyland, Hélène Jacques, Piotr Bryl, Lucie Beaulieu, André Marette
Journal: Metabolism (2011)
Use of sequential quadrupling dose regimens to study efficacy of inhaled corticosteroids in asthma
Authors: K Phillips
Journal: Thorax (2003)

<b>Background:</b> Inhaled corticosteroids are widely used to treat asthma. There is a need to be able to compare different inhaled corticosteroids and different doses of an inhaled corticosteroid to determine potency and dose equivalence, but measuring efficacy in a dose related manner is difficult because of their slow onset of action. There is uncertainty about the role of sequential dosing regimens and the best end point for such studies. We have explored the use of sequential quadrupling dose regimens and a range of end points to assess the response to budesonide in subjects with asthma. <b>Methods:</b> 21 subjects with mild asthma, aged 18–65, took part in a randomised three way crossover study comparing two sequential and one non-sequential regimen, separated by at least 3 weeks. The sequential regimens consisted of increasing doses of inhaled budesonide (100, 400 1600 μg/day) with each dose being given for 1 or 2 weeks; the non-sequential regimen consisted of 1600 μg/day for 2 weeks with end points measured after 1 and 2 weeks. The end points studied included the provocative dose of adenosine monophosphate causing a 20% fall in forced expiratory volume in 1 second (PD<sub>20</sub>AMP), lung function, symptoms, and bronchodilator use. <b>Results:</b> There was a dose related increase in PD<sub>20</sub>AMP with both sequential dose regimens. The increase in PD<sub>20</sub>AMP ranged from 1.49 doubling doses (DD) following the lowest dose (100 μg/day) to 3.1 DD following the highest dose (1600 μg/day) in the 1 week sequential regimen and from 1.98 to 4.03 DD in the 2 week sequential regimen; standard deviations (SD) for the changes in PD<sub>20</sub>AMP ranged from 1.3 to 2.6 DD. Changes in forced expiratory volume in 1 second (FEV<sub>1</sub>) and morning peak expiratory flow rate (PEFR) were dose related but small and more variable (maximum change in FEV<sub>1</sub> = 148 ml, SD 228 ml), while changes in evening PEFR, symptoms, and bronchodilator use were small and not dose related. Change in PD<sub>20</sub>AMP after budesonide 1600 μg did not differ significantly between regimens. <b>Conclusion:</b> Combining PD<sub>20</sub>AMP measurements with a sequential regimen of three quadrupling doses of an inhaled corticosteroid given for 1 or 2 weeks provides clear dose-response curves for comparative studies. PD<sub>20</sub>AMP is a more sensitive end point for this purpose than FEV<sub>1</sub>, PEFR, symptoms, or relief inhaler use.
Hemodynamic Support by Left Ventricular Assist Devices Reduces Cardiomyocyte DNA Content in the Failing Human Heart
Authors: Jeremias Wohlschlaeger, Bodo Levkau, Gero Brockhoff, Klaus Jürgen Schmitz, Moritz von Winterfeld, Atsushi Takeda, Nobuakira Takeda, Jörg Stypmann, Christian Vahlhaus, Christof Schmid, Natalia Pomjanski, Alfred Böcking, Hideo Andreas Baba
Journal: Circulation (2010)

Whether adult cardiomyocytes have the capacity to regenerate in response to injury and, if so, to what extent are still issues of intense debate. In human heart failure, cardiomyocytes harbor a polyploid genome. A unique opportunity to study the mechanism of polyploidization is provided through the setting of hemodynamic support by left ventricular assist devices. Hence, the cardiomyocyte DNA content, nuclear morphology, and number of nuclei per cell were assessed before and after left ventricular assist device support.In 23 paired myocardial samples, cardiomyocyte ploidy was investigated by DNA image cytometry, flow cytometry, and in situ hybridization. Nuclear cross-sectional area and perimeters were measured morphometrically, and the binucleated cardiomyocytes were counted. The median of the cardiomyocyte DNA content and the number of polyploid cardiomyocytes both declined significantly from 6.79 c to 4.7 c and 40.2% to 23%, whereas a significant increase in diploid cardiomyocytes from 33.4% to 50.3% and in binucleated cardiomyocytes from 4.5% to 10% after unloading was observed.The decrease in polyploidy and increase in diploidy after left ventricular assist device suggest a numeric increase in diploid cardiomyocytes (eg, through cell cycle progression with completion of mitosis or by increased stem cells). The cardiac regeneration that follows may serve as a morphological correlate of the recovery observed in some patients after unloading.
Abstract 4985: The UCSC Cancer Genomics Browser
Authors: Jingchun Zhu, J. Zachary Sanborn, Stephen C. Benz, Brian Craft, Christopher Szeto, Kord M. Kober, Mary Goldman, Laurence Meyer, Charles Vaske, Eric Collisson, Joshua Stuart, David Haussler
Journal: Cancer Research (2011)

Abstract The UCSC Cancer Genomics Browser (https://genome-cancer.ucsc.edu) comprises a suite of web-based tools to integrate, visualize and analyze cancer genomics and clinical data. The browser displays whole-genome views of genome-wide experimental measurements for multiple samples alongside their associated clinical information. Multiple datasets can be viewed simultaneously as coordinated “heatmap tracks” to compare across studies or different data modalities. Users can order, filter, aggregate, classify, and display data interactively based on any given feature set including clinical features, annotated biological pathways, and user-contributed collections of genes. Integrated standard statistical tools provide dynamic quantitative analysis within all available datasets. The browser hosts a growing body of publicly available cancer genomics data from a variety of cancer types, including data generated from the Cancer Genome Atlas project. Multiple consortiums use the browser on confidential prepublication data enabled by private installations. Many new features have been added, including the hgMicroscope tumor image viewer, hgSignature for real-time genomic signature evaluation on any browser track, and PARADIGM pathway tracks to display integrative pathway activities. The browser is integrated with the UCSC Genome Browser; thus inheriting and integrating the Genome Browser's rich set of human biology and genetics data that enhances the interpretability of the cancer genomics data. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4985. doi:10.1158/1538-7445.AM2011-4985
Small gallstones, preserved gallbladder motility, and fast crystallization are associated with pancreatitis
Authors: Niels G. Venneman, Willem Renooij, Jens F. Rehfeld, Gerard P. vanBerge‐Henegouwen, Peter M. N. Y. H. Go, Ivo A. M. J. Broeders, Karel J. van Erpecum
Journal: Hepatology (2005)

Acute pancreatitis is a severe complication of gallstones with considerable mortality. We sought to explore the potential risk factors for biliary pancreatitis. We compared postprandial gallbladder motility (via ultrasonography) and, after subsequent cholecystectomy, numbers, sizes, and types of gallstones; gallbladder bile composition; and cholesterol crystallization in 21 gallstone patients with previous pancreatitis and 30 patients with uncomplicated symptomatic gallstones. Gallbladder motility was stronger in pancreatitis patients than in patients with uncomplicated symptomatic gallstones (minimum postprandial gallbladder volumes: 5.8 ± 1.0 vs. 8.1 ± 0.7 mL; P = .005). Pancreatitis patients had more often sludge (41% vs. 13%; P = .03) and smaller and more gallstones than patients with symptomatic gallstones (smallest stone diameters: 2 ± 1 vs. 8 ± 2 mm; P = .001). Also, crystallization occurred much faster in the bile of pancreatitis patients (1.0 ± 0.0 vs. 2.5 ± 0.4 days; P < .001), possibly because of higher mucin concentrations (3.3 ± 1.9 vs. 0.8 ± 0.2 mg/mL; P = .04). No significant differences were found in types of gallstones, relative biliary lipid contents, cholesterol saturation indexes, bile salt species composition, phospholipid classes, total protein or immunoglobulin (G, M, and A), haptoglobin, and α-1 acid glycoprotein concentrations. In conclusion, patients with small gallbladder stones and/or preserved gallbladder motility are at increased risk of pancreatitis. The potential benefit of prophylactic cholecystectomy in this patient category has yet to be explored. (HEPATOLOGY 2005.)
THE EFFECT OF RHEUMATOID FACTORS AND OF ANTIGLOBULINS ON IMMUNE HEMOLYSIS IN VIVO
Authors: Manuel E. Kaplan, James H. Jandl
Journal: The Journal of Experimental Medicine (1963)

Studies were undertaken in man and in the rat comparing the effects of rheumatoid factors and immune antiglobulins on red cells sensitized with incomplete antibodies. The interaction of immune antiglobulins with sensitized red cells produced (a) agglutination in vitro and (b) an accelerated sequestration of the sensitized cells in vivo. In contrast, rheumatoid macroglobulins, although capable of agglutinating Rh-sensitized red cells in vitro, did not modify their destruction in vivo. The failure of rheumatoid factors to function as antiglobulins in vivo appears to reflect their non-reactivity with sensitized cells in whole serum. It is suggested: (a) that the native (7S) gamma globulins of plasma competitively inhibit rheumatoid factors from reacting with fixed antibody in the blood stream; (b) that if these macroglobulins do indeed have pathogenetic activity, this may be limited to body fluids of low protein content.
Absolute Determination of IgE Antibodies to Grass Pollen Allergens
Authors: D. Vervloet, P. Bongrand, J. Charpin
Journal: Allergy (1978)

Knowledge of specific IgE bound on immunosorbent as assayed by RAST is useful but cannot give a complete description of the biological states of patients concerning IgE antibodies. Using a computer program based on a least squares error method and knowing the amount of bound specific IgE antibodies to grass pollen antigens in a serum at each of the four tested dilutions it is possible to calculate the absolute value of specific IgE antibody level, the relative value of affinity constant and the relative proportion of IgE antibodies to the total amount of specific (IgE plus non-IgE) antibodies. It is found that specific IgE antibodies account for high percentages of the total IgE protein (mean of 20%). High differences in affinity constant and in the proportion of IgE antibodies to the total amount of antibodies could be found between sera. Severity of grass pollen allergy could be related to the absolute level of IgE antibody, but no definite conclusion could be made on the importance of affinity constant and the proportion of IgE antibodies to the total amount of antibodies.
Penetration of cells by asbestos fibers
Authors: J. M. G. Davis, R. E. Bolton, J. Garrett
Journal: Environmental Health Perspectives (1974)

Studies on the behavior of asbestos fibers within tissues have shown that the only cells that regularly contain asbestos are macrophages and their derivatives. However, these cells actively incorporate the asbestos fibers by the process of phagocytosis, and there is little evidence of direct penetration. Examination of the gut lining after prolonged asbestos ingestion has shown no evidence of dust penetration either through or between the epithelial cells. The structure and arrangement of these cells is discussed, and it is suggested that they are exceptionally well adapted to prevent penetration by any solid material.
The Use of Stories in Clinical Research and Health Policy
Authors: John F. Steiner
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Child sexual abuse presenting as organic disease.
Authors: R. M. Brown, M. J. Perkins
Journal: BMJ (1989)

3 observations de fillettes (entre 5 ans et 6 ans 1/2) hospitalisees en psychiatrie pour comportements anormaux. Apres quelque temps les electroencephalogrammes de sommeil et les tests et interrogatoires montrent que la cause de l'alteration mentale est un viol par le pere ou le compagnon de la mere
Hypertrophic Obstructive Cardiomyopathy Due to Fabry's Disease
Authors: Wilson S. Colucci, Beverly H. Lorell, Frederick J. Schoen, Michael J. Warhol, William Grossman
Journal: New England Journal of Medicine (1982)

The diagnosis of hypertrophic obstructive cardiomyopathy is based on a constellation of clinical and hemodynamic findings including left ventricular hypertrophy, asymmetric septal hypertrophy, small left ventricular cavity size, systolic anterior motion of the mitral valve, and a dynamic pressure gradient between the left ventricle and the systemic arteries.1 2 3 Recently, we studied a 32-year-old man with known Fabry's disease involving the kidneys, who had the typical clinical, echocardiographic, and invasive hemodynamic findings of hypertrophic cardiomyopathy with a dynamic left ventricular-arterial pressure gradient. However, percutaneous right and left ventricular endomyocardial biopsies demonstrated extensive myocardial involvement by Fabry's disease, and suggested that in . . .
Observations on Respiration in Articular Cartilage
Authors: M. A. Bowie, O. Rosenthal, G. Wagoner
Journal: Annals of the Rheumatic Diseases (1941)

LITTLE was known about the metabolism of articular cartilage till 1936, when Bywaters1 published the first quantitative data on the subject.He reported a well-defined glucolysis, equivalent per cell to that of other adult tissues, but was unable to demon- strate an appreciable utilization of oxygen.It seemed improbable that a tissue without any respiratory ability could synthesise the complex constituents ofits matrix.Since Bywaters had employed old equine cartilage in his study, reinvestigation of the problem, using cartilage of young as well as of older animals, seemed worth while.Accordingly, bovine articular cartilage secured from young, adult, and old animals was employed.
Developments Like Major Resection Bone Allografts Foster Progress in Tissue-Banking Technology
Authors: Timothy F. Kirn
Journal: JAMA (1987)

SIXTEEN YEARS AGO, Henry Mankin, MD, removed the entire distal segment of the femur from a woman who had a giant cell tumor and replaced it with a section of cadaveric bone. Today, Mankin says, the patient has a functioning leg and is still doing well. Major resection bone allografting, which can involve replacing all or part of a joint and suturing the tendons and ligaments together, is one example of a medical development that is increasing the need for human tissue and fostering progress in tissue-banking technology. Mankin, a professor of orthopedic surgery at Harvard Medical School, Boston, says allografting of skeletal parts has had a long, but "slightly tarnished," history—stretching back almost 100 years. Ending years of frustrating failure was the discovery, in the 1950s, that freezing the bone prior to transplantation reduced the immune reaction presumably responsible for the large number of failures. Bone allografting in general
INCREASED LEVELS OF CIRCULATING ENDOTHELIAL PROGENITOR CELLS IN INTRACORONARY BLOOD OF ST-ELEVATION MYOCARDIAL INFARCTION PATIENTS CORRELATE WITH MICROVASCULAR DAMAGE.
Authors: Italo Porto, Luigi M Biasucci, Giovanni Luigi De Maria, Luca Di Vito, Antonio M Leone, Giampaolo Niccoli, Alessandra Tritarelli, Giuliana Di Rocco, Maurizio Capogrossi, Filippo Crea
Journal: Journal of the American College of Cardiology (2010)