tbuckley/cabot-search huggingface dataset:
Land Application of Treated Sewage Sludge: Community Health and Environmental Justice
Authors: Amy Lowman, Mary Anne McDonald, Steve Wing, Naeema Muhammad
Journal: Environmental Health Perspectives (2013)

In the United States, most of the treated sewage sludge (biosolids) is applied to farmland as a soil amendment. Critics suggest that rules regulating sewage sludge treatment and land application may be insufficient to protect public health and the environment. Neighbors of land application sites report illness following land application events.We used qualitative research methods to evaluate health and quality of life near land application sites.We conducted in-depth interviews with neighbors of land application sites and used qualitative analytic software and team-based methods to analyze interview transcripts and identify themes.Thirty-four people in North Carolina, South Carolina, and Virginia responded to interviews. Key themes were health impacts, environmental impacts, and environmental justice. Over half of the respondents attributed physical symptoms to application events. Most noted offensive sludge odors that interfere with daily activities and opportunities to socialize with family and friends. Several questioned the fairness of disposing of urban waste in rural neighborhoods. Although a few respondents were satisfied with the responsiveness of public officials regarding sludge, many reported a lack of public notification about land application in their neighborhoods, as well as difficulty reporting concerns to public officials and influencing decisions about how the practice is conducted where they live.Community members are key witnesses of land application events and their potential impacts on health, quality of life, and the environment. Meaningful involvement of community members in decision making about land application of sewage sludge will strengthen environmental health protections.
Acquired Hemolytic Anemia Secondary to Boeck's Sarcoid
Authors: Wilk O. West
Journal: New England Journal of Medicine (1959)

A CQUIRED hemolytic anemia secondary to splenic involvement with Boeck's sarcoid is rare. Only 5 cases of the association of sarcoidosis and hemolytic anemia have been reported,1 2 3 4 5 and only 1 of these showed sarcoid involvement of the spleen.3 Two cases exhibited hemolytic anemia of the spherocytic type.4 , 5 ft was not clear whether these cases of spherocytosis were of the congenital or acquired types. If they were of congenital origin, the relation to sarcoidosis would be coincidental. This report, therefore, constitutes the second verified case of hemolytic anemia secondary to splenic involvement with Boeck's sarcoid that has been reported.Since 1930, . . .
Pemetrexed Alone or in Combination with Cisplatin in Previously Treated Malignant Pleural Mesothelioma: Outcomes from a Phase IIIB Expanded Access Program
Authors: Pasi A. Jänne, Antoinette J. Wozniak, Chandra P. Belani, Mary-Louise Keohan, Helen J. Ross, Jonathan A. Polikoff, David M. Mintzer, Zhishen Ye, Matthew J. Monberg, Coleman K. Obasaju
Journal: Journal of Thoracic Oncology (2006)
Determination of Relative Changes in Cardiac Output from Noncalibrated Earpiece Dye-Dilution Curves
Authors: Ivor T. Gabe, John Tuckman, John P. Shillingford
Journal: Circulation Research (1962)

Many investigations require information on percentage changes in cardiac output rather than absolute values. This study investigates a simple method for measuring such relative changes, using noncalibrated earpiece dye-dilution curves. The basic principle involved is that, in an ideal system, the areas beneath successive dilution curves produced by equal injections of indicator are inversely proportional to the cardiac outputs. Applied to the earpiece dye-dilution curves, the restrictive assumptions relate mainly to linearity of response to blood concentration of dye and to the constancy of the blood volume of the ear. The method has been tested by recording simultaneous earpiece and arterial cuvette dye curves produced by injections of Coomassie Blue during changes in posture, exercise, and intravenous administration of vasoactive drugs. The relative changes in cardiac output predicted from the earpiece curves compared well with those from the arterial cuvette.
Targeted deletion of α-adducin results in absent β- and γ-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice
Authors: Raymond F. Robledo, Steven L. Ciciotte, Babette Gwynn, Kenneth E. Sahr, Diana M. Gilligan, Narla Mohandas, Luanne L. Peters
Journal: Blood (2008)
MEDICAL PRACTICE IN TURKEY
Authors: H. L. Underwood
Journal: JAMA (1949)

ABSTRACT To the Editor:— Recently I spent a vacation investigating the present state of medical practice in Turkey. Having spent several years there (1902-1909) at which time native civilian medical practice was deplorably lacking in both quality and quantity, I wished to learn whether the amazing transformation of the social, educational and cultural life of the people, following in the wake of the revolution in the early 1920's was also apparent in their medical practice, hospitals and sanitation.In general, I found that to be the case. Such physicians as Dr. Becet Uz, ex-minister of Turkey's Department of Health, Dr. Kadri Olcar and Dr. Surreyeh Gorduren, all of Ankara, the capital, are physicians of a high order of excellence devoted to their profession and generous of their time and courtesy to the visitor. Dr. Gorduren is an internationally known ophthalmologist and is on the corresponding editorial staff of the British Journal
Residence near high voltage facilities and risk of cancer in children.
Authors: J H Olsen, A Nielsen, G Schulgen
Journal: BMJ (1993)

OBJECTIVE--To investigate whether residence before and after birth near 50 Hz high voltage installations increases a child9s risk of cancer and whether risk correlates with the strength of the magnetic field. DESIGN--A population based case-control study. SETTING--Denmark. SUBJECTS--1707 children under the age of 15 with leukaemia, tumour of the central nervous system, or malignant lymphoma diagnosed in 1968-86 and 4788 children taken from the central population register. MAIN OUTCOME MEASURES--Proximity before and after birth to existing or former 50-400 kV electrical transmission connections and substations and associated historical electromagnetic fields calculated on the basis of current load on line, phase ordering of line, and distance from the dwelling. RESULTS--A significant association was seen between all major types of childhood cancer combined and exposure to magnetic fields from high voltage installations of &gt; or = 0.4 microT (odds ratio 5.6). At &gt; or = 0.25 microT no significant association was seen (odds ratio 1.5). A possible association was also seen with cases of Hodgkin9s disease separately at &gt; or = 0.1 microT. CONCLUSIONS--On the basis these results and additional descriptive data on electricity consumption and incidence of childhood cancer in Denmark since the 1940s it was concluded that the proportion of childhood cancer possibly caused by 50 Hz electromagnetic fields must be small.
Cardiovascular Risk Assessment in the Development of New Drugs for Obesity
Authors: William R. Hiatt, Allison B. Goldfine, Sanjay Kaul
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human insulin and porcine insulin in the treatment of diabetic children: comparison of metabolic control and insulin antibody production.
Authors: N P Mann, D I Johnston, W G Reeves, M A Murphy
Journal: BMJ (1983)

Semisynthetic human insulin and highly purified porcine insulin were compared in a double blind crossover study in 21 diabetic children. Glycosylated haemoglobin values at the end of four month treatment periods were higher after treatment with human insulin than after treatment with porcine insulin (mean 15.7% (SD 2.3%) v 14.2% (2.3%); p less than 0.01). Higher fasting blood glucose concentrations occurred during treatment with human insulin than with porcine insulin (mean 12.0 (SD 2.1) v 11.0 (2.4) mmol/1; mean 216 (SD 38) v 198 (43) mg/100 ml; p less than 0.05), but there were no significant differences at other time points during the day. The incidence of hypoglycaemia was similar for both treatment groups. Concentrations of antibody reactive with porcine and human insulins were similar for the two treatment groups, although greater fluctuation was observed in the amount of antibody reactive with human insulin. Semisynthetic human insulin is safe and effective in diabetic children, although further work is needed to devise regimens which achieve optimal blood glucose control.
EFFECT OF EPINEPHRIN ON THE HEART
Authors: W. J. Woolston
Journal: JAMA (1924)

Several cases have been reported showing the effect of intracardial injections of epinephrin. The following case is interesting because of the apparent complete cessation of respiration and circulation for more than a quarter of an hour. M. J., a colored woman, aged 28, with a diagnosis of chronic salpingitis, was sent in for an operation on the service of Dr. W. J. Woolston, at the Cook County Hospital. A visiting physician of wide experience administered caudal anesthesia, consisting of procain, epinephrin, hydrochloric acid and potassium bicarbonate, in solution. From two to three minutes after injection, respirations and circulation apparently ceased. The pupils were dilated and did not respond to light. Artificial respirations were started, and at the end of eighteen minutes, there was no change. Then 1 c.c. of epinephrin solution, 1: 1,000, was injected into the heart. Circulation began almost immediately; the pulse was bounding and rapid. Two minutes
LEISHMANIOSIS (ORIENTAL SORE) OF THE NASAL MUCOSA
Authors: L. B. Bates
Journal: JAMA (1913)

The ease here described is the fifth one of oriental sore which has been encountered in Ancon Hospital. As the pathogenic agent, epidemiology, histopathology and treatment of the previous cases have recently been described in detail,<sup>2</sup>I wish here only to record the unique feature of the case under consideration. <h3>REPORT OF CASE</h3> The patient, E. N., a Panamanian farmer aged 35, is a resident of San Carlos, Los Santos Province, Panama. His present lesions are of three years' duration. He is married and has six children. His wife, children and acquaintances are free from similar lesions. Almost the entire length of the helix of the left ear is rather deeply ulcerated. The ulcer has the characteristic peripheral fossa and raised edges, and is entirely covered with a thick, hard, black crust. A similar condition, but to less extent, exists on the right ear and on the extensor. surfaces
Polyethylene glycolated interleukin‐2 as maintenance therapy for acute myelogenous leukemia in second remission
Authors: Peter H. Wiernik, Janice P. Dutcher, Mary Todd, Geralyn Caliendo, Laura Benson
Journal: American Journal of Hematology (1994)

Abstract Seven patients in second complete remission of acute myeloid leukemia (AML) aged 19–65 years were treated with polyethylene glycolated interleukin‐2 (PEG IL‐2), 1 × 10 6 U/M 2 IV weekly as the sole postremission therapy. Second remission duration was in the range of 4–49+ months, and three patients had a second remission duration substantially longer than their first (6,21 +, and 42+ months). The results suggest that PEG IL‐2 may prolong second remission duration in AML and that a prospective randomized study designed to test that idea is warranted. © 1994 Wiley‐Liss, Inc.
An action agenda for HIV and sex workers
Authors: Chris Beyrer, Anna-Louise Crago, Linda-Gail Bekker, Jenny Butler, Kate Shannon, Deanna Kerrigan, Michele R Decker, Stefan D Baral, Tonia Poteat, Andrea L Wirtz, Brian W Weir, Françoise Barré-Sinoussi, Michel Kazatchkine, Michel Sidibé, Karl-Lorenz Dehne, Marie-Claude Boily, Steffanie A Strathdee
Journal: The Lancet (2014)
Countries' long term progress in health isn't related to economic growth, report finds
Authors: P. Moszynski
Journal: BMJ (2010)

Most developing countries made dramatic yet often underestimated progress in health, education, and basic living standards in recent decades, concludes a report released this week. It also says that many of the poorest countries saw the greatest gains.

The detailed new analysis of long term trends, the latest in the annual series of the United Nations’ human development reports, was released this week by the UN Development Programme in New York. The UN secretary general Ban Ki-moon said at the launch that the annual reports, with their annual Human Development Index, first introduced 20 years ago, had “changed the way we see the world.”

He said, “We have learnt …
The Electrocardiogram in Congenital Heart Disease
Authors: A. J. BRINK, CATHERINE A. NEILL
Journal: Circulation (1955)

The incidence of the four main types of axis deviation in each diagnostic group of congenital malformations of the heart was found by an examination of 2,752 electrocardiograms from the Harriet Lane Home Cardiac Clinic. Records from patients with dextrocardia or dextrarotation of the heart, and those with complete bundle branch block were excluded. The precordial and unipolar limb leads in the 289 electrocardiograms which showed left axis deviation were examined, and the types of precordial pattern most frequently seen in the different diagnostic groups analyzed. It is concluded that the precordial patterns show considerable difference in the various malformations associated with left axis deviation, and are of diagnostic aid.
Diastolic function in patients with severe heart failure: comparison of the effects of enoximone and nitroprusside.
Authors: H C Herrmann, T D Ruddy, G W Dec, H W Strauss, C A Boucher, M A Fifer
Journal: Circulation (1987)

To assess whether the phosphodiesterase inhibitor enoximone has a specific, direct effect on left ventricular diastolic function distinct from its inotropic and vasodilator actions, we compared the effects of enoximone and the pure vasodilator nitroprusside in 11 patients with severe heart failure. Mean (+/- SEM) left ventricular ejection fraction was 0.20 +/- 0.03. Simultaneous left ventricular pressure and radionuclide angiographic volume were obtained at baseline, during infusion of nitroprusside, and after intravenous administration of enoximone. Left ventricular end-diastolic pressure (LVEDP) and volume (LVEDV) decreased with both agents (p less than .01 vs control); LVEDP was lower for nitroprusside than for enoximone (p less than .01) despite a similar LVEDV. Nitroprusside decreased the time constant of exponential left ventricular pressure decay, TL (measured by the logarithmic method), from 84 +/- 10 to 65 +/- 8 msec (p less than .01) but had no significant effect on TD (measured by the derivative method), maximum negative dP/dt, or the peak rate of early diastolic filling. Enoximone shortened TL from 86 +/- 12 to 61 +/- 9 msec (p less than .01) and increased maximum negative dP/dt from 897 +/- 101 to 1135 +/- 134 mm Hg/sec (p less than .01) but did not affect TD or the peak filling rate. The left ventricular diastolic pressure-volume relation was shifted downward in only three of 11 patients on nitroprusside and three of 11 patients on enoximone, and these shifts were attenuated by adjusting for simultaneous changes in right atrial pressure.(ABSTRACT TRUNCATED AT 250 WORDS)
Prevalence, Classification and Natural History of Gastric Varices: A Long–Term Follow–Up Study in 568 Portal Hypertension Patients
Authors: Shiv K. Sarin, Deepak Lahoti, Sanjay P. Saxena, Nandguri S. Murthy, Uday K. Makwana
Journal: Hepatology (1992)

To determine the prevalence and natural history of gastric varices, we prospectively studied 568 patients (393 bleeders and 175 nonbleeders) with portal hypertension (cirrhosis in 301 patients, noncirrhotic portal fibrosis in 115 patients, extrahepatic portal vein obstruction in 117 patients and hepatic venous outflow obstruction in 35 patients). Primary (present at initial examination) gastric varices were seen in 114 (20%) patients; more were present in bleeders than in non-bleeders (27% vs. 4%, respectively; p < 0.001). Secondary (occurring after obliteration of esophageal varices) gastric varices developed in 33 (9%) patients during follow-up of 24.6 +/- 5.3 mo. Gastric varices (compared with esophageal varices) bled in significantly fewer patients (25% vs. 64%, respectively). Gastric varices had a lower bleeding risk factor than did esophageal varices (2.0 +/- 0.5 vs. 4.3 +/- 0.4, respectively) but bled more severely (4.8 +/- 0.6 vs. 2.9 +/- 0.3 transfusion units per patient, respectively). Once a varix bled, mortality was more likely (45%) in gastric varix patients. Gastric varices were classified as gastroesophageal or isolated gastric varices. Type 1 gastroesophageal varices (lesser curve varices) were the most common (75%). After obliteration of esophageal varices, type 1 gastroesophageal varices disappeared in 59% of patients and persisted in the remainder; bleeding from persistent gastroesophageal varices was more common than it was from gastroesophageal varices that were obliterated (28% vs. 2%, respectively; p < 0.001). Type 2 gastroesophageal varices, which extend to greater curvature, bled often (55%) and were associated with high mortality. Type 1 isolated gastric varices patients had only fundal varices, with a high (78%) incidence of bleeding.(ABSTRACT TRUNCATED AT 250 WORDS)
STUDIES ON THE MODE OF SPREAD OF B. ENTERITIDIS MOUSE TYPHOID INFECTION
Authors: Leslie T. Webster, Caspar Burn
Journal: The Journal of Experimental Medicine (1927)

1. Single cell mouse strains of B. enteritidis from smooth-susceptible colonies were, under the various conditions tested, of the same high degree of virulence. 2 year old cultures, strains obtained both in interepidemic and epidemic periods, and "reverted" strains from variant colonies showed the same degree of pathogenicity. 2. Single cell strains from variant smooth, mucoid,and rough phage-resistant colonies were definitely less virulent than the usual smooth-susceptible strains. The loss of virulence in each instance resulted apparently from contact with bacteriophage which rendered the individual cells incapable of multiplication in the animal tissues. 3. A reduction of virulence was induced experimentally when washed cultures of the highly pathogenic smooth-susceptible cells were exposed to bacteriophage and thus rendered incapable of multiplication in the inoculated animals.
A gene (PEX) with homologies to endopeptidases is mutated in patients with X–linked hypophosphatemic rickets
Authors: F. Francis, S. Hennig, B. Korn, R. Reinhardt, P. de Jong, A. Poustka, H. Lehrach, P.S.N Rowe, J.N. Goulding, T. Summerfield, R. Mountford, A.P. Read, E. Popowska, E. Pronicka, K.E. Davies, J.L.H. O'Riordan, M.J. Econs, T. Nesbitt, M.K. Drezner, C. Oudet, S. Pannetier, A. Hanauer, T.M. Strom, A. Meindl, B. Lorenz, B. Cagnoli, K.L. Mohnike, J. Murken, T. Meitinger
Journal: Nature Genetics (1995)
Quantitative Aspects of Pinocytosis and the Intracellular Fate of N-acetyl-α-D-glucosaminidase in Sanfilippo B Fibroblasts
Authors: K. von Figura, H. Kresse
Journal: Journal of Clinical Investigation (1974)

The cellular uptake of N-acetyl-alpha-D-glucosaminidase, the deficient enzyme in Sanfilippo B disease, and the intracellular fate and metabolic effect of this enzyme have been investigated in Sanfilippo B and normal fibroblasts. For both genotypes the uptake is highly efficient (up to 0.025 mU/h/mg cell protein), specific and constant over a period of at least 6 days. It is probable that the enzyme protein is taken up by adsorptive pinocytosis. The enzymatic activity as well as the biological activity towards (35)SO(4)-labeled mucopolysaccharides persist in Sanfilippo B cells with a half-life of 34 h, indicating the intralysosomal localization of the pinocytosed enzyme. The data obtained are discussed with regard to a possible enzyme replacement therapy. For Sanfilippo B disease the doses used in the past are considered to be insufficient to cause measurable effects.
Medicare Part D
Authors: Dana P. Goldman, Geoffrey F. Joyce
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal