tbuckley/cabot-search huggingface dataset:
DORSAL SITTING POSITION FOR MAKING DIRECT LARYNGEAL AND UPPER ESOPHAGEAL EXAMINATIONS
Authors: J. Paul de River
Journal: JAMA (1926)

In making a direct laryngeal or esophageal examination, it is essential that the patient be placed in such a position that the examiner may readily see the parts without undue strain on the patient or himself. In many instances in which it is necessary to make a hasty examination, assistants are not always available to hold the patient's head over the end of the table (Rose-Boyce). The position here described, which is applicable to home or office use, is easily performed without an assistant. It is extremely useful in making a quick examination of the larynx or upper portion of the esophagus, or when a large number of patients have to receive examinations and treatment, as in tuberculosis hospitals. The patient is seated on a low stool. On each side of him is placed a chair, on which he rests his arms for support. The chairs should be higher than
"THE GROUND GLASS OBSESSION"
Authors: An Army Surgeon
Journal: JAMA (1918)

<h3>To the Editor:</h3> —The editorial with this title (The Journal, March 23, 1918, p. 852) I fear is far from the truth, especially in this part of the country. I wish you really knew how much there is going on along this line. Enclosed are a few cuttings; these are absolutely authentic reports from headquarters. If it stopped at ground glass it might be easy; but steel filings, stone, sand of a very irritating kind, aluminum or wire filings, and brassy metal powders have all been found, and chemicals, such as potassium bitartrate. In fact, it is a growing evil, and it does not stop at flour stuffs. We reported to the attorney's office cases of delicatessen canned goods all "doctored," and had a big round up this week after a most serious finding. I regret the necessity of asking you to withhold my name from publication for this time,
Health Research and the HIPAA Privacy Rule
Authors: R. R. Faden, A. C. Mastroianni, J. P. Kahn
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Patient's Right to Safety — Improving the Quality of Care through Litigation against Hospitals
Authors: George J. Annas
Journal: New England Journal of Medicine (2006)

Many experts believe that the threat of malpractice suits impedes the use of error-reporting systems to make hospitals safer. Annas argues that more lawsuits, not fewer, are needed. He believes that the courts should recognize a right to safety so that hospitals that fail to implement measures to improve safety could be sued when patients are injured owing to preventable errors.
Chlamydial perihepatitis (Curtis-Fitz-Hugh-syndrome) after hydrotubation.
Authors: J N Simson
Journal: BMJ (1984)

this category are mainly meats and meat products, milk and cream, cheese, and cakes and biscuits. Equally, caterers should provide similar information in appropriate ways. The concentration of alcohol (ethanol) in beers, ciders, wines, spirits, and any other drinks containing more than 1-2% of alcohol by volume should be printed on the container in per? centage by volume. The concentration in drinks that are dispensed should be displayed prominently at retail outlets. Where appropriate, foods or food products with lower contents of saturated plus trans fatty acids and/or common salt than is at present customary should be made available to the general public. Examples are milk, meats, and meat products such as sausages, hamburgers and minced meats, margarines (trans fatty acids), and breads and other cereal products.
THE TREND OF MODERN PSYCHIATRY AND ITS RELATION TO GENERAL MEDICINE.
Authors: JOHN PUNTON
Journal: JAMA (1904)

Amid the kaleidoscopic changes incident to modern medical progress, none are more conspicuous and striking than those which pertain to the study of psychiatry. To the average practitioner medical psychology was until within a very recent period, a sealed book, and even to-day its study is greatly neglected by many of our medical schools and colleges. This indifference is well understood, however, when we remember the hypothetical character of former available knowledge concerning morbid psychical phenomena, as well as the difficulties which beset its practical clinical application in general medical practice. Moreover the numerous exigencies that belong to the care, management and treatment of the insane soon led the general practitioner to lose interest in its study, and all such cases were willingly referred by him to those members of our profession whose tastes or opportunities led them to select this form of practice, hence, the alienist became through sheer
Protein Synthesis and the Genetic Code in Subcellular Systems Derived from Normal and Neoplastic Animal and Human Tissues.
Authors: Manuel Ochoa
Journal: Annals of Internal Medicine (1965)

s1 November 1965Protein Synthesis and the Genetic Code in Subcellular Systems Derived from Normal and Neoplastic Animal and Human Tissues.Manuel Ochoa Jr., M.D., I. B. Weinstein, M.D.Manuel Ochoa Jr., M.D.Search for more papers by this author, I. B. Weinstein, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-917_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe escape from host control characteristic of tumor cells may reflect changes in the mechanism of protein synthesis or alterations in the genetic code. The present study compares normal and neoplastic cells with respect to amino acid coding and the biochemical steps in protein synthesis.As inEscherichia coli, protein synthesis by extracts from human chronic lymphocytic leukemia, mouse L1210 leukemia, a human plasma cell tumor, the rat MtT/W5 mammosomatotropic pituitary tumor, rabbit reticulocytes, and normal rat liver could be redirected by synthetic messenger ribonucleic acid (RNA) (mRNA). A group of synthetic mRNAs, differing in their base compositions, have been... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTHE ROLE OF DIABETOGENIC HYPERINSULINISM IN THE PATHOGENESIS OF PROSTATIC HYPERPLASIA AND MALIGNANCY* 1 November 1965Volume 63, Issue 5Page: 917-918KeywordsCellsGeneticsLiverLymphocytic leukemiaPituitary tumorsPlasma cellsProtein synthesisRNARabbitsReticulocytes Issue Published: 1 November 1965 PDF DownloadLoading ...
The Clinical Meeting
Authors: Samuel Vee
Journal: JAMA (1969)

<h3>To the Editor:—</h3> My curiosity is raised about the cover illustration of your Oct 20 issue, Frank Mechau's "Saturday P. M." Are the dashing hombres on their galloping horses earlier day medical conventioners? Is the woman at the saloon door waiting for a physicianhusband astray from the scientific sessions? Does the equine anatomy facing the viewer carry symbolic connotation? Your cover legend offers no clue.
Relationship of Sphincter of Oddi Spike Bursts to Gastrointestinal Myoelectric Activity in Conscious Opossums
Authors: Ryuichi Honda, James Toouli, Wylie J. Dodds, Sushil Sarna, Walter J. Hogan, Zen Itoh
Journal: Journal of Clinical Investigation (1982)

The oppossum sphincter of Oddi (SO) exhibits peristaltic spike bursts with accompanying contraction waves that originate proximally in the sphincter of Oddi and propagate toward the duodenum. In this study we recorded myoelectrical activity of the opossum SO and upper gastrointestinal tract in six conscious animals using chronically implanted electrodes. Biopolar electrodes were implanted in the gastric antrum, duodenum, SO segment, jejunum, and ileum. During fasting the frequency of SO spike bursts, scored as number per minute, showed a cyclic pattern consisting of four phases (A to D). Phase A had a low spike burst frequency of ∼2/min that lasted ∼20 min. In phase B, the spike burst frequency increased progressively during a 40-45 min interval culminating in a short interval of phase C activity characterized by a maximal spike burst frequency of ∼5/min. During phase D, the spike bursts decreased over 15 min to merge with the low frequency of phase A and the cycle repeated. Cycle length of the interdigestive SO cycle, 87±11 SD min, was virtually identical with that of the interdigestive migrating myoelectric complex (MMC) of the upper gastrointestinal tract. The onset of phase C activity in the SO began 1-2 min before phase III of the MMC activity in the duodenum. Feeding abolished the cyclic pattern of spike burst activity in the SO as well as in the upper gastrointestinal tract. After feeding the SO spike bursts occurred at a frequency of 5-6/min for at least 3 h. We conclude that: (a) During fasting, the oppossum SO exhibits cyclic changes in its spike burst frequency; (b) Maximal spike burst frequency of the SO occurs virtually concurrent with passage of phase III MMC activity through the duodenum and; (c) Feeding abolishes the interdigestive cyclic spike burst pattern of the SO as well as that of the gastrointestinal tract.
SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma
Authors: David Wrench, Pamela Leighton, Christine F. Skibola, Lucia Conde, Jean-Baptiste Cazier, Janet Matthews, Sameena Iqbal, Emanuela Carlotti, Csaba Bödör, Silvia Montoto, Maria Calaminici, John G. Gribben, T. Andrew Lister, Jude Fitzgibbon
Journal: Blood (2011)
Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitis
Authors: R Pfutzer
Journal: Gut (2002)

Hereditary pancreatitis (HP) is usually caused by mutations in the cationic trypsinogen (PRSS1) gene, especially R122H or N29I. We sequenced the PRSS1 gene in the proband of families without these common mutations. Novel R122C and N29T mutations were detected in independent families that segregated with the disease in an autosomal dominant fashion. The R122C mutation eliminates the arginine autolysis site as with R122H mutations. The N29T mutation may also enhance intrapancreatic trypsin activity as has been demonstrated in vitro. Identification of these new mutations requires special attention as commonly used detection methods may fail.
Beastly nodules instead of beauty: pseudoepitheliomatous hyperplasia developing after application of permanent make-up
Authors: E.A. Coors, R. Wessbecher, P. Von Den Driesch
Journal: British Journal of Dermatology (2004)

Journal Article Beastly nodules instead of beauty: pseudoepitheliomatous hyperplasia developing after application of permanent make‐up Get access E.A. Coors, E.A. Coors Department of Dermatology, University of Hamburg, Martinistr. 52, 20246 Hamburg, Germany Department of Dermatology, Krankenhaus Bad Cannstatt, Prießnitzweg 24, 70374 Stuttgart, Germany E.A.Coors. E‐mail: ecoors@uke.uni‐hamburg.de Search for other works by this author on: Oxford Academic Google Scholar R. Wessbecher, R. Wessbecher Department of Dermatology, University of Hamburg, Martinistr. 52, 20246 Hamburg, Germany Department of Dermatology, Krankenhaus Bad Cannstatt, Prießnitzweg 24, 70374 Stuttgart, Germany Search for other works by this author on: Oxford Academic Google Scholar P. Von Den Driesch P. Von Den Driesch Department of Dermatology, University of Hamburg, Martinistr. 52, 20246 Hamburg, Germany Department of Dermatology, Krankenhaus Bad Cannstatt, Prießnitzweg 24, 70374 Stuttgart, Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 150, Issue 5, 1 May 2004, Page 1027, https://doi.org/10.1111/j.1365-2133.2004.05962.x Published: 01 May 2004 Article history Accepted: 30 November 2003 Published: 01 May 2004
Association Between Family History and Coronary Heart Disease Death Across Long-Term Follow-Up in Men
Authors: Justin M. Bachmann, Benjamin L. Willis, Colby R. Ayers, Amit Khera, Jarett D. Berry
Journal: Circulation (2012)

Family history of coronary heart disease (CHD) has been well studied as an independent risk factor for CHD events in the short term (<10 years). However, data are sparse on the association between family history and risk for CHD across long-term follow-up.We included 49 255 men from the Cooper Center Longitudinal Study. Premature family history of CHD was defined as the presence of angina, myocardial infarction, angioplasty, or bypass surgery in a relative <50 years of age. Cause-specific mortality was obtained from the National Death Index. The association between premature family history and cardiovascular disease (CVD) or CHD death was compared across 3 unique follow-up periods (0-10, >10-20, and >20 years). Lifetime risk was estimated by use of a modified survival analytic technique adjusted for competing risk with non-CVD death as the competing event. After 811 708 person-years of follow-up, there were 919 CHD deaths and 1456 CVD deaths. After adjustment for traditional risk factors, premature family history was associated with CHD mortality >10 to 20 years (1.59; 95% confidence interval, 1.14-2.22) and >20 years (1.43; 95% confidence interval, 1.05-1.95) with wider confidence intervals at 0 to 10 years (1.32; 95% confidence interval, 0.76-2.31). Similar findings were observed for CVD mortality. Compared with men without a family history of coronary artery disease, premature family history was associated with an ≈50% higher lifetime risk for both CHD and CVD mortality (13.7% versus 8.9% and 21% versus 14.1%, respectively).Premature family history was associated with a persistent increase in both CHD and CVD mortality risk across long-term follow-up, resulting in significantly higher lifetime risk estimates.
Risk of gastrointestinal effects with COX-2 inhibitors and NSAIDs: How strong is the evidence?
Authors: Bernard G Bannwarth
Journal: BMJ (2005)

Rationing in response to NHS deficits: rural patients are likely to be affected most See News, p 1426Editor-News that pressing financial problems have caused NHS trusts in Suffolk to set new "thresholds" to treatments such as joint replacements reinforces concerns raised by a recent BMA survey of medical directors of trusts in which over a third of respondents anticipated reductions of key services in response to funding shortfalls. 1 2 What has hitherto escaped comment is how cuts in services are far more likely to be felt in some parts of the country than others.Deficits in the NHS are invariably presented as a problem of financial mismanagement, but the pattern of deficits shows that the current resource allocation model discriminates against particular communities.According to the recently published accounts for 2004-5, 3 89 out of 303 (30%) English primary care trusts ended the year in deficit.The table shows how 301 of these trusts are distributed accorded to fifths of deprivation and rurality.Primary care trusts serving populations that are in both the most rural and the least deprived fifth were most likely to be in financial difficulties.Seventeen of the 25 (68%) in this category were in deficit.These trusts received the lowest funding allocation per head (£995).By contrast, only 3% (one of 34) of the primary care trusts serving populations that are in both the most urban and the most deprived fifths failed to break even in 2004-5.These trusts received the highest funding allocations per head (£1405).This shows that poor financial management can at best only partly explain why some trusts are in deficit.The pattern of deficits implies that NHS funding provides insufficient resources for rural areas, for comparatively affluent areas, and, most particularly, for areas that are both rural and affluent.The risk is that such measures will result in NHS services being subject to a new postcode lottery, in which rural residents are more likely to lose out.
HBV + HCV = HCC?
Authors: M E CRAMP
Journal: Gut (1999)

See article on page 284 

Most people infected with hepatitis C virus (HCV) develop a chronic infection with persistent viraemia and are at risk of progressive liver damage. However, the outcome of chronic HCV infection is extremely variable and is influenced by many factors, including HCV genotype, HCV viral load, route of infection, age at infection, sex, and alcohol consumption. Ultimately, it is the progression to cirrhosis that is the key determinant of both morbidity and mortality1 and a better understanding of additional influences likely to promote this development is needed.

Both hepatitis B virus (HBV) and HCV are transmitted parenterally and coinfection is not uncommon, particularly in intravenous drug users and in countries with a high prevalence of HBV infection.2Coinfection with evidence of chronic HBV and HCV seems to result in more severe liver disease than either infection alone,3with an increased risk of liver cancer2 and probably an increased risk of fulminant hepatitis when superinfection with HCV occurs on the background of chronic HBV.4 

The presence of hepatitis B surface and/or hepatitis B core antibodies (anti-HBs and anti-HBc) …
World Bank Report Says Reallocate Resources
Authors: Charles Marwick
Journal: JAMA (1993)

IN 1990, the nations of the world spent $1.7 trillion, 8% of the total world product, on health services. But in terms of improved health they did not get as much value from this expenditure as they might have.  This is the conclusion of the 1993 annual report from the World Bank, Washington, DC. EntitledInvesting in Health, the report was prepared by a team headed by Dean T. Jamison, PhD, UCLA School of Public Health, Los Angeles, Calif.  The World Bank's annual reports, issued every July, are major statements on international development policy. In the past, they have been devoted to such macroeconomic topics as debt, poverty, and the environment. This year's is the first World Bank annual report ever to be devoted to health. Its 120 000 copies, printed in eight languages, are very widely distributed, sent to the ministers of finance and central banks of every nation
Presence of receptors for polymerized albumin in HBsAg-containing hepatocytes and hepatoma cell line
Authors: Swan N. Thung, Michael A. Gerber
Journal: Hepatology (1981)

Recent evidence suggests that hepatitis B virions (HBV) and HBsAg particles contain receptors for polymerized human serum albumin (pHSA). We studied, by immunohistochemical techniques, the relationship between HBsAg and pHSA receptors in liver tissue from eight patients with chronic HBV infection and in a human hepatocellular carcinoma cell line (PLC/PRF/5) producing HBsAg. Both parallel sections and double fluorescent antibody staining of liver tissue demonstrated that only HBsAg-containing hepatocytes expressed pHSA receptors. The receptors could not be demonstrated in eight HBsAg negative livers. Sequential studies of PLC/PRF/5 cells revealed that pHSA and HBsAg emerged simultaneously in the cytoplasm, on the cell surface, and in the supernatant culture media. These findings indicate that pHSA receptors are closely associated with HBsAg during its synthesis and secretion by hepatocytes and suggest that the receptors are HBV-specific.
A Natural History of Homosexuality
Authors: Larry Rudiger
Journal: JAMA (1997)

No longer the crime that dare not speak its name, homosexuality has become a hot topic. An impressive and diverse range of research programs is currently focused on the lives of gay, lesbian, bisexual, and transgendered people. With all this activity, a nonspecialist looking for a summary of the issues surrounding homosexuality might have trouble finding a starting point. To fill this gap, Frances Mark Mondimore, MD, has written an often well researched and warmly presented book. Unfortunately, the book fails to deliver on his promise of a thorough introduction to the topic.  Mondimore organizes the material into four parts. First, historical accounts of like-gendered eroticism are surveyed. For those who haven't (and probably wouldn't) read the source materials, Mondimore conveys the basic information effectively. He convincingly describes the importance of this research for understanding our culture's present attitude toward homosexuality.  In the strongest part of the book, Mondimore
Argentaffin Tumor of the Ileum with Intussusception
Authors: E. T. McCartney, I. Stewart
Journal: BMJ (1959)

Argentaffin Tumour of the Ileum with IntussusceptionAccording to Dangremond (1942), only 283 argentaffin tumours of the small intestine had been recorded in the literature since they were first recognized as a distinct entity by Oberndorfer (1907).Ariel (1939), in a review of the cases published between 1930 and 1938, was able to record the age of the patients in 70 instances, and their disposition in decades was as follows:
National Study of Internal Medicine Manpower: IV. Residency and Fellowship Training 1977-1978 and 1978-1979
Authors: ALVIN R. TARLOV
Journal: Annals of Internal Medicine (1979)

The National Study of Internal Medicine Manpower gathered data on the number of residents in training in internal medicine and the number of fellows in subspecialty training, for 1977-1978 and for 1978-1979. In the latter period, there were 16 720 residents in all years of training. The 7.2% average annual increase in the number of first-year residents during the earlier half of the 1970s slowed in 1977-1978 and 1978-1979 to 4.6% and 4.2%, respectively, reflecting a similar decline in the number of medical school graduates. The most important finding of the study is that the steep rise (10.6% per year) in the number of subspecialty fellowship trainees characteristic of the years 1972-1973 through 1976-1977 has abated. The number of fellows in subspecialty training has remained essentially constant in the past 2 years. Thus, although the number of residents continued to increase and the number of fellows remained constant, the number (and percentage) of internists in training who intend to practice general internal medicine rose.
Silodosin Therapy for Lower Urinary Tract Symptoms in Men with Suspected Benign Prostatic Hyperplasia: Results of an International, Randomized, Double-Blind, Placebo- and Active-Controlled Clinical Trial Performed in Europe
Authors: Christopher R. Chapple, Francesco Montorsi, Teuvo L.J. Tammela, Manfred Wirth, Evert Koldewijn, Eldiberto Fernández Fernández
Journal: European Urology (2010)