tbuckley/cabot-search huggingface dataset:
Abstract 1072: TAM and CD44 in medullary thyroid carcinoma
Authors: MARTA MIYAZAWA, MARIA JOSE C. P. SANTOS, LARISSA V. BIM, ERIKA S. L. ORTI-RADUAN, FLÁVIA O. F. VALENTE, ADAUTO F. NUNES, ROSANA DELCELO, RUI M. B. MACIEL, JANETE M. CERUTTI
Journal: Cancer Research (2014)

Abstract Background: Tumor-associated macrophages (TAMs) are alternatively activated or M2 macrophages that infiltrate cancer tissues. It has been suggested that TAMs exert several pro-tumor functions by releasing several growth factors and proangiogenic cytokines that favor tumor progression. In fact, TAM density has been associated with poor prognosis. Although it is well known the pro-tumor roles of TAM in several tumor types, its role in medullary thyroid cancer (MTC) is still unknown. We here evaluated the M2 macrophage marker CD163 in MTC and correlated with RET mutational status and clinical and pathological features. Because it has been suggested TAMs could interact with CD44-positive tumor cells to during tumorigenesis process, we also investigated the expression of CD44 in MTC. Patients and Methods: CD163 and CD44 expression we investigated in 78 MTC by immunohistochemistry (IHC). Because hereditary form is caused by germline mutations in the RET gene, all patients were screened for RET mutations (exons 8, 10, 11, 13-16) in the DNA isolated from blood samples. Those MTC that were negative for RET germline mutations, were also screened for somatic mutations in the RET gene (exons 10, 11 e 16). Results: Germline mutation in the RET gene were identified in 29 patients (p.G533C, p.C609Y, p.C611Y, p.C620Y, p.C634R, p.C634Y/Y791F, p.S891A and p.M918V). Approximately 49 cases are sporadic cases in which somatic RET mutations were identified in about 6 cases (p.M918T, p.C634R and p.C634Y). CD163 expression was mainly found in sporadic MTC when compared to hereditary MTC (p=0.021), suggesting that TAM may play a role in the progression of sporadic MTC. On the other hand CD44 expression was mainly found in hereditary MTC than in sporadic cases (p=0.017), particularly in patients with RET germlime mutation at codon C634. Conclusion: TAM seems to be more important for sporadic MTC tumorigenesis when compared to hereditary MTC. On the other hand, CD44 expression correlated with hereditary MTC, particularly in patients with mutation at codon C634. Citation Format: MARTA MIYAZAWA, MARIA JOSE C. P. SANTOS, LARISSA V. BIM, ERIKA S. L. ORTI-RADUAN, FLÁVIA O. F. VALENTE, ADAUTO F. NUNES, ROSANA DELCELO, RUI M. B. MACIEL, JANETE M. CERUTTI. TAM and CD44 in medullary thyroid carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1072. doi:10.1158/1538-7445.AM2014-1072
From the FDA
Authors: Stuart L. Nightingale
Journal: JAMA (1986)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Research governance is important
Authors: Mick E Bond
Journal: BMJ (2006)

EDITOR—I have experience of obtaining research governance approval from both sides, as a primary care trust research management and governance manager and as an active researcher who has recently gained approval for a project across the local strategic health authority.1 2

Firstly, I see no reason why trusts should be asking fellow NHS employees for honorarycontracts.2 All NHS organisations are signed up to research governance, and that should be sufficient proof of their …
TCT-232 Outcomes for Percutaneous Coronary Intervention versus Coronary Artery Bypass Graft Surgery for Unprotected Left Main Coronary Artery Occlusion presenting as ST Elevation Myocardial Infarction
Authors: Apurva Patel, James E. Lai, Roosha Parikh, J. R. Exequiel Pineda, Stephen Ellis, E. Murat Tuzcu, Samir Kapadia
Journal: Journal of the American College of Cardiology (2014)
Points from Letters: Hazards of Temperature Taking
Authors: B. J. Freedman
Journal: BMJ (1970)

BITISH(often in his prime) rather than take the risk of a breakdown in health in the sub- sequent five years.Compare the lot of the man who gets an award, say, at 50.Not only can he afford to ease off earlier, he can also spare the time to attend clinical meetings, administrative committees, and write papers, and in due course this bears the fruit of an even higher award.Although the system is supposedly
OXYGEN THERAPY IN MYOCARDIAL INFARCTION
Authors: Orville Horwitz
Journal: JAMA (1952)

<h3>To the Editor:—</h3> In the recent report by Borden, Ebert, and Wilson (<i>J. A. M. A.</i><b>148</b>:1370 [April 19] 1952), we were interested to find that the chemical determinations of oxygen in arterial blood taken from patients suffering from acute myocardial infarction with various complications confirm the data previously obtained by the Millikan oximeter and reported by Godfrey, Pond, and Wood (<i>Am. J. M. Sc.</i><b>216</b>:605, 1948) and later by Penneys (<i>Bull. Johns Hopkins Hosp.</i><b>90</b>:192, 1952). Borden and co-workers note that, unless there is a considerable lowering of arterial oxygen saturation, only a small amount of oxygen can be added to the amount already carried by the blood, by increasing the saturation of the hemoglobin and by increasing the amount of oxygen in solution. They state that with inhalation of 40% and 100% oxygen increases of arterial oxygen content of only 0.9 and 2.2 vol. % occur.
1011-119 Effect of Nisoldipine on Hypoperfused Dyssynergic Viable Myocardium After Myocardial Infarction
Authors: Claudio Brunelli, Oberdan Parodi, Gianmario Sambuceti, Luca Corsiglia, Gian M. Rosa, Assuero Giorgetti, Gian P. Bezante, Nicola Nista, Salvatore Caponnetto
Journal: Journal of the American College of Cardiology (1995)
Mental health services in England among best in Europe, says WHO
Authors: L. Eaton
Journal: BMJ (2008)

A report on mental health services in Europe highlights wide variations among states and indicates that services in England are among the best available.⇓



The World Health Organization’s report was published on world mental health day, 10 October, alongside a report on mental health services worldwide. It gives an extensive overview of funding levels, staffing, primary and secondary provision, and the mechanisms in place to monitor human rights.

Better research into mental health and improved translation of that research into good practice are among the goals that WHO identifies for further action.

Many countries have made substantial progress in the past …
Analyzing the soybean transcriptome during autoregulation of mycorrhization identifies the transcription factors GmNF-YA1a/b as positive regulators of arbuscular mycorrhization
Authors: Sara Schaarschmidt, Peter M Gresshoff, Bettina Hause
Journal: Genome biology (2013)

Abstract Background Similarly to the legume-rhizobia symbiosis, the arbuscular mycorrhiza interaction is controlled by autoregulation representing a feedback inhibition involving the CLAVATA1-like receptor kinase NARK in shoots. However, little is known about signals and targets down-stream of NARK. To find NARK-related transcriptional changes in mycorrhizal soybean ( Glycine max ) plants, we analyzed wild-type and two nark mutant lines interacting with the arbuscular mycorrhiza fungus Rhizophagus irregularis . Results Affymetrix GeneChip analysis of non-inoculated and partially inoculated plants in a split-root system identified genes with potential regulation by arbuscular mycorrhiza or NARK. Most transcriptional changes occur locally during arbuscular mycorrhiza symbiosis and independently of NARK. RT-qPCR analysis verified nine genes as NARK-dependently regulated. Most of them have lower expression in roots or shoots of wild type compared to nark mutants, including genes encoding the receptor kinase GmSIK1, proteins with putative function as ornithine acetyl transferase, and a DEAD box RNA helicase. A predicted annexin named GmAnnx1a is differentially regulated by NARK and arbuscular mycorrhiza in distinct plant organs. Two putative CCAAT-binding transcription factor genes named GmNF-YA1a and GmNF-YA1b are down-regulated NARK-dependently in non-infected roots of mycorrhizal wild-type plants and functional gene analysis confirmed a positive role for these genes in the development of an arbuscular mycorrhiza symbiosis. Conclusions Our results indicate GmNF-YA1a/b as positive regulators in arbuscular mycorrhiza establishment, whose expression is down-regulated by NARK in the autoregulated root tissue thereby diminishing subsequent infections. Genes regulated independently of arbuscular mycorrhization by NARK support an additional function of NARK in symbioses-independent mechanisms.
Esophageal Perforation With Obturator Airway
Authors: Eric E. Harrison
Journal: JAMA (1979)

<h3>To the Editor.—</h3> We read the article "Esophageal Perforation With Obturator Airway" (241:1154, 1979). In our emergency medical system we have employed the esophageal obturator airway for several years, and during a period when we inserted 1,156 of them, we became aware of four esophageal perforations. One patient did not survive the initial resuscitation attempts; one died four days later of massive pulmonary emboli, and the esophageal rupture was found at postmortem examination. Another died four days after repair of the esophageal rupture and had had an acute myocardial infarction as the initial event precipitating the cardiac arrest. The last patient had a respiratory arrest secondary to congestive heart failure without recent infarction and was treated semiconservatively with cervical esophagostomy and gastrostomy and survived. In these patients only one esophageal rupture was associated with incorrect use of the esophageal obturator airway, when it was allowed to remain in place while the
896 THE NATURAL HISTORY OF IDIOSYNCRATIC DRUG-INDUCED LIVER INJURY (DILI): FOLLOW-UP IN A COHORT OF PATIENTS IDENTIFIED IN A SINGLE TERTIARY CARE CENTRE
Authors: B. Garcia-Munoz, S. Lopez-Ortega, Y. Borraz, A. Fernandez Castaner, M.C. Lopez-Vega, M. Robles, N. Ortiz, I. Cueto, M.I. Lucena, R.J. Andrade
Journal: Journal of Hepatology (2008)
MYCOSIS FUNGOIDES AND NEUROMYOPATHY
Authors: AZIZ R. KURWA, E. E. PAYNE
Journal: British Journal of Dermatology (1969)

Journal Article MYCOSIS FUNGOIDES AND NEUROMYOPATHY Get access AZIZ R. KURWA, AZIZ R. KURWA Department of Dermatology, Royal Infirmary, xsCardiff Search for other works by this author on: Oxford Academic Google Scholar E. E. PAYNE E. E. PAYNE Department of Dermatology, Royal Infirmary, xsCardiff Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 5, 1 May 1969, Pages 333–337, https://doi.org/10.1111/j.1365-2133.1969.tb13992.x Published: 01 May 1969 Article history Accepted: 21 August 1968 Published: 01 May 1969
Abstract 3226: In vitro evaluation of a thermally targeted conjugate of a highly potent doxorubicin derivative
Authors: Teuta Opacak-Bernardi, Leslie Robinson, Khalid Abu Ajaj, Felix Kratz, Drazen Raucher
Journal: Cancer Research (2011)

Abstract Doxorubicin is an anthracycline used in the treatment of many types of cancer. It intercalates into the strands of DNA to inhibit the progression of topoisomerase II, stopping the cell from replicating. The side effects, however, are severe and include neutropenia, alopecia, nausea, myelosuppression, and cardiotoxicity. Due to its nonspecific effect, high doses are needed to treat cancer cells. These high doses are inadvertently harmful to normal cells. n-Butyldiacatodoxorubicin (NBD) is a doxorubicin derivative that is converted in vivo to 2-pyrrolinodoxorubicin that is ∼ 1000-fold more active than doxorubicin. Because of its high potency, an efficient drug delivery system is needed in order to deliver NBD to the tumor site. To retain potent antitumor activity while reducing systemic toxicity, NBD was coupled to a thermally responsive macromolecular carrier. The macromolecular carrier is based on elastin-like polypeptide (ELP) which remains in solution at physiological temperature and accumulates in the tumor site when external hyperthermia is applied. The N-terminus of ELP was modified with the cell penetrating peptide (CPP) SynB1. SynB1 is a 19 amino acid peptide derived from porcine leukocytes which facilitates cellular uptake of the ELP carrier. NBD was attached to a terminal cysteine residue of ELP by conjugation of a 6-maleimidocaproyl hydrazone derivative of NBD. This NBD drug bears an acid-sensitive linker that is cleavable at the lysosomal/endosomal pH, which allows a controlled intracellular release of the drug. The ELP-delivered NBD inhibited MCF-7 cells growth in the nanomolar range. In addition, inhibition of cell proliferation was enhanced two-fold when hyperthermia was applied and cell proliferation was accompanied by apoptosis, which was enhanced 3-fold in MCF-7 cells when SynB1-ELP-NBD aggregation was induced with hyperthermia. These results suggest that the SynB1-ELP-NBD conjugate is a promising candidate for investigating its thermally targeting properties against solid tumors in animal models. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3226. doi:10.1158/1538-7445.AM2011-3226
Book: The Story of Taxol: Nature and Politics in the Pursuit of an Anti-Cancer Drug
Authors: R. Camidge
Journal: BMJ (2001)

Jordan Goodman, Vivien Walsh Cambridge University Press, £18.95, pp 282 ISBN 0 521 56123 X Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> In the 1950s, the United States government set up a programme to look for cancer cures in the natural world. The US Department of Agriculture, in conjunction with the National Cancer Institute (NCI), sent researchers off into the wilds, and over the next 30 years 15 000 plants were collected and analysed from around the globe. This all sounds like pretty swashbuckling stuff, yet the real drama of the programme lay not in the eventual discovery of Taxol—a powerful antineoplastic agent extractable from the bark of the Pacific yew—but in what happened next. … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
Left Ventricular Function After Extended Hypothermic Preservation of the Heart Is Dependent on Functional Coronary Capillarity
Authors: Lorraine H. Manciet, Kenneth A. Fox, Jack G. Copeland, Donald S. Wilson, Paulette R. Reimer, Paul F. McDonagh
Journal: Circulation (1995)

Background A growing body of knowledge has led to the hypothesis that injury to the microcirculation during hypothermic myocardial preservation may result in decreased contractility of hearts upon reperfusion. Methods and Results To test this hypothesis, we examined the relationship between no-reflow and left ventricular function after hypothermic cardiac preservation after reperfusion with solutions containing dilute whole blood (DWB) or washed red blood cells (K2RBC). Rat hearts were arrested with high-potassium cardioplegia, then flushed and stored for 6 hours in low-potassium cardioplegia at 4°C. Hearts were reperfused at a constant flow rate (4 mL/min) with K2RBC for 60 minutes (group 1, n=5) or DWB for 7 minutes followed by 53 minutes of K2RBC (group 2, n=5). Left ventricular developed pressure (LVDP) was measured with an intraventricular balloon. Immediately after functional assessment, hearts were perfused with an india ink solution to mark flow, then glutaraldehyde. Morphometric techniques were used to determine the degree of capillary compression [Δd̄(c)], perfused capillary number per fiber area [Q A (0) P ], and perfused capillary surface area per fiber volume [S V (c,f) P ]. Capillaries were moderately compressed in both groups after reperfusion (group 1, 19±1%; group 2, 20±1%). Q A (0) P and S V (c,f) P were highly correlated with Δd̄(c) in hearts reperfused with K2RBC ( r =.92 and r =.92; P &lt;.01). Although statistically significant, the correlation was not as strong in DWB-reperfused hearts ( r =.66 and r =.67; P &lt;.05). LVDP was correlated to Q A (0) P and S V (c,f) P ( r =.86 and r =.87, respectively) for groups 1 and 2. Conclusions The weaker correlation between capillary perfusion and capillary compression in DWB-reperfused hearts suggests that factors other than compression contribute to no-reflow after hypothermic preservation. Regardless of the composition of the reperfusate, recovery of left ventricular function after hypothermic ischemia is directly related to coronary capillary perfusion upon reperfusion.
Chest pain and neck discomfort in a young man
Authors: D. Linden, D. Courtney, M. Shyamsundar, R. Hewitt
Journal: BMJ (2014)

A 21 year old man presented to his general practitioner with intermittent left sided pain in the anterior chest wall associated with neck discomfort. The pain was reported as “stabbing” in nature and had arisen suddenly while watching television. He had no history of trauma before the onset of symptoms, and the pain was not exacerbated by inspiration or effort. His medical history and physical examination were unremarkable. His GP referred him for outpatient cardiology assessment and prescribed simple analgesia. Several days later he attended the local emergency department with worsening chest pain and dyspnoea. On examination, chest expansion was equal and breath sounds were normal, although there was crepitus on auscultation of the precordium. Palpation of the neck and supraclavicular fossae detected subcutaneous emphysema. His respiratory rate was 25 breaths/min and his oxygen saturations were 100%. A chest radiograph (fig 1⇓) was abnormal and he was admitted for computed tomography of the chest. No abnormalities were seen on a water soluble oral contrast swallow. His full blood count and inflammatory markers were within normal limits. Fig 1 The patient’s chest radiograph on admission
The Treatment of Spina Bifida
Authors: J. Morton
Journal: BMJ (1875)

CASE.-A housekeeper, aged 38, single, came under my care in November last.Sixteen months ago, she first noticed a swelling in the right breast, which gradually grew larger, and was excised in Feb- ruary I874.Five weeks later, a fresh tumour had already formed, and was likewise removed by excision.Soon afterwards, numerous cancerous nodules sprang up about the cicatrices in the axillary glands, and also in the left breast; and, as further surgical operations appeared unadvisable, Mlr.Irvine sent her to me.When I first saw her, on November 23rd, the cancerous cachexia was strongly marked.There was intense weakness and depression of spirits; the face bore an expression of agony; the complexion was sallowv; there was complete loss of appetite, great wasting, restlessness at night, a pulse of 120, and sixty respirations in the minute.Towards evening, well marked febrile movements set in, and there was excruciating pain, more espe- cially in the left shoulder.Under these circumstances, no treatment could be expected to pro- duce a decided change in the aspect of the case; but, as the patient and her friends wvere most anxious that something should be done, electrolysis was suggested.On November 30th, I introduced a needle connected with the cathode of lBecker-MIuirhead's battery into one of the cancerous nodes on the right side of the chest, and placed the anode to the left shoulder.The power of current wvas gradually raised
Predictors of duodenal ulcer healing during treatment with cimetidine.
Authors: M Okada, T Yao, K Maeda, T Yamamoto, K Saigenji, Y Okada, K Sakamoto, K Tanaka
Journal: Gut (1990)

A two phase study was performed to identify factors that influence the healing rate of duodenal ulcer. The study included an initial clinical trial in 145 patients and a second trial in a further 61 patients. All patients were prescribed cimetidine at a daily dose of 800 mg for six weeks. The factors examined were age, sex, inpatient or outpatient treatment, duration of present ulcer pain, past history of duodenal ulcer, smoking, drinking, the length of time it took for symptoms to resolve after beginning treatment, and the characteristics of the ulcers themselves. Eighty four per cent of the duodenal ulcers healed after six weeks. Using univariate and multivariate analyses, it was found that three factors indicated a significant delaying effect on healing: (1) symptoms that persisted two weeks after treatment had begun; (2) heavy smoking (20 or more cigarettes daily); and (3) severe narrowing of the duodenal bulb. Patients with none of the three unfavourable factors (n = 90) had a healing rate of 95.6% compared with patients with one (n = 45) or two or more (n = 10) factors, whose healing rates were 75.6% and 20.0% respectively (p less than 0.001). The corresponding figures in a second study were 88.9%, 55.0%, and 0%, respectively (p less than 0.001). A prognostic score based on these three factors represents the severity of duodenal ulcers with regard to healing in patients treated with cimetidine.
IMPROVEMENT IN IRON STATUS AND LIVER FUNCTION IN PATIENTS WITH TRANSFUSIONAL IRON OVERLOAD WITH LONG-TERM SUBCUTANEOUS DESFERRIOXAMINE
Authors: A.V. Hoffbrand, A. Gorman, M. Laulicht, M. Garidi, J. Economidou, P. Georgipoulou, M.A.M. Hussain, D.M. Flynn
Journal: The Lancet (1979)
Telomere length as a prognostic parameter in chronic lymphocytic leukemia with special reference to VH gene mutation status
Authors: Pawel Grabowski, Magnus Hultdin, Karin Karlsson, Gerard Tobin, Anna Åleskog, Ulf Thunberg, Anna Laurell, Christer Sundström, Richard Rosenquist, Göran Roos
Journal: Blood (2005)