tbuckley/cabot-search huggingface dataset:
USES AND LIMITATIONS OF ESTROGENS IN GYNECIC PRACTICE
Authors: E. C. HAMBLEN
Journal: JAMA (1941)

Estrogens constitute a diverse group of chemical compounds capable of producing estrous phenomena in experimental animals and reproduction in woman, to a great degree the physiologic functions which are attributed to the follicular hormone of her ovaries. There are two general classes of estrogens: (1) those which are identical chemically with the steroids extracted from the ovaries, placentas or body fluids, i. e., hormones, and (2) those synthetic pharmacologically active agents which bear no structural chemical likeness to natural hormones. All three of the estrogenic hormones—estrone, estriol and estradiol—have been extracted from woman's urine and are available commercially as free steroids or as esters. During the past three years estrogenic compounds derived from stilbene, particularly diethylstilbestrol and its esters, have been subjected to broad clinical investigations looking toward their release into commerce by the Food and Drug Administration. The primary pharmacologic action of estrogens is on the genital system: endometrial,
Impact of Plaque Rupture on Infarct Size in ST-Segment Elevation Anterior Acute Myocardial Infarction
Authors: Ikuyoshi Kusama, Kiyoshi Hibi, Masami Kosuge, Naoki Nozawa, Hiroyuki Ozaki, Hideto Yano, Shinnichi Sumita, Kengo Tsukahara, Jun Okuda, Toshiaki Ebina, Satoshi Umemura, Kazuo Kimura
Journal: Journal of the American College of Cardiology (2007)
Nadolol plus Isosorbide Mononitrate Compared with Sclerotherapy for the Prevention of Variceal Rebleeding
Authors: Càndid Villanueva, Joaquim Balanzó, Maria T. Novella, German Soriano, Sergio Sáinz, Xavier Torras, Xavier Cussó, Carlos Guarner, Francisco Vilardell
Journal: New England Journal of Medicine (1996)

Patients who have bleeding from esophageal varices are at high risk for rebleeding and death. We compared the efficacy and safety of endoscopic sclerotherapy with the efficacy and safety of nadolol plus isosorbide mononitrate for the prevention of variceal rebleeding.
Approach after thrombolytic therapy: invasive versus conservative management: global registry of acute coronary events
Authors: Immad Sadig, Harold L. Dauerman, Robert J. Goldberg, Werner Klein, David Brieger, Ph.Gabriel Steg, Gilles Montalescot, José López-Sendón, Andrzej Budaj, Joel M. Gore
Journal: Journal of the American College of Cardiology (2002)
Cardiac Rupture due to Metastases from a Carcinoma of the Antrum
Authors: DONALD H. SINGER, BERNARD CZERNOBILSKY, LESTER A. STEINBERG
Journal: Circulation (1958)

The case is described of a 70-year-old white man with a primary anaplastic carcinoma of the right maxillary antrum, and with widespread visceral dissemination, including metastases to the heart. Myocardial rupture was noted to have occurred through one of the metastatic lesions. To the best of our knowledge this is the fourth instance of rupture as a sequel to tumorous infiltration of the heart. Among the metastases were one or more to a clear-cell adenoma of the left kidney. This instance of metastasis of "cancer to cancer" is the second case of this rare condition in the recent autopsy material of the Beth Israel Hospital.
HYPNOSIS, SUGGESTION, AND DISSOCIATION
Authors: W. Brown
Journal: BMJ (1919)

On Jatnuary 2nd, 1919, Captain E. T. Coombe took; over the case.The patient lay in a lethargic state, curled up; the head was retracted; very wasted.When awakened was fairly intelli- gent, but he fell asleep immediatelv he was left alone.-No con- valsions; no "cephalic cry."Intenee pain on moving head, gult hea(lache at times.Pupils widely dilated.Paralysis of iklwer limbs, incontinence of.urine anid faeces.Ophtlialmo- scopic examination (artificial dilatation of pupils not neces- sary): Optic disc pale; blood vessels engorged.Diaginosis: Encephalitis lethargica.On Jantuary 3rd lumbar puncture was performed, and 20 to 30 c.cm. fluid withdrawn; it was under great pressure, milkv, and somewhat opalescent.Ten grains of urotropin in 10 c.cm. of physiological salt solution were injectedl inito the spinal canal.The patient improved somewhat after the lumbar
Quantitative analysis of major, minor and trace elements in gallbladder bile of patients with and without gallstones
Authors: Robert C. Harvey, Dale Taylor, Connie N. Petrunka, Andrew D. Murray, Steven M. Strasberg
Journal: Hepatology (1985)

The concentration of 25 major, minor and trace elements in human bile was determined by inductively coupled plasma atomic emission spectrometry. Gallbladder bile was obtained during surgery from patients with cholesterol gallstones, pigment stones and with no biliary tract abnormalities (controls). Comparison of the concentration of elements (microgram per gram of solids) did not reveal any significant differences among the three patient groups. The in vitro nucleation time was not related to the concentration of any element measured.
TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction
Authors: A Kemal Topaloglu, Frank Reimann, Metin Guclu, Ayse Serap Yalin, L Damla Kotan, Keith M Porter, Ayse Serin, Neslihan O Mungan, Joshua R Cook, Mehmet N Ozbek, Sazi Imamoglu, N Sema Akalin, Bilgin Yuksel, Stephen O'Rahilly, Robert K Semple
Journal: Nature Genetics (2008)
Influence of Previous Oral Contraception and Maternal Oxytocin Infusion on Neonatal Jaundice
Authors: S. R. Gould, U. Mountrose, D. J. Brown, W. L. Whitehouse, D. E. Barnardo
Journal: BMJ (1974)

A prospective study of serum bilirubin levels on the first and sixth days of life in a series of 181 infants has failed to provide evidence to suggest that previous maternal oral contraception, maternal oxytocin infusion, epidural anaesthesia, or breast-feeding are factors influencing neonatal jaundice.
PROSPECTIVE RANDOMIZED TRIAL ON RADIATION DOSE ESTIMATES OF CT ANGIOGRAPHY IN PATIENTS SCANNED WITH A HIGH-PITCH-FIRST SCAN STRATEGY &amp;ndash; THE PROTECTION IV STUDY
Authors: Joerg Hausleiter, Simon Deseive, Francesca Pugliese, Erick Alexanderson, Aloha Meave, Martin Hadamitzky, Tanja Meyer, Albrecht Will, Albert Schoemig, Stefan Martinoff
Journal: Journal of the American College of Cardiology (2012)
Magnetic microcapsule exploration in the gastrointestinal cavity of the origins of colorectal cancer-associated DNA-damaging agents in the human diet.
Authors: I O'Neill, S Bingham, A Ellul, B Incaurgarat
Journal: Environmental Health Perspectives (1993)

Magnetically recoverable, semipermeable microcapsules have been devised for covalent entrapment of reactive substances in the intestinal cavity to biomonitor potentially DNA-damaging agents and the effects of etiologically important components of the human diet. These microcapsules have been shown to trap five types of agents in vivo, namely, carcinogen electrophiles, nitrosating agents, mutagens/carcinogens having a planar molecular structure, and as-yet unidentified endogenous cross-linking agents and precursors of reactive oxygen species. Substantial alterations in both total metabolites and types of metabolites trapped from [14C]benzo(a)pyrene were found to be caused by increasing (within the human intake range) the dietary levels of beef protein and dietary fiber. The system thus responds to a variety of potentially critical agents and in a manner consistent with epidemiologically important dietary modulators for colorectal carcinogenesis. Work toward recognizing entrapped endogenous agents has also begun.
Duplications of noncoding elements 5′ of SOX9 are associated with brachydactyly-anonychia
Authors: Ingo Kurth, Eva Klopocki, Sigmar Stricker, Jolieke van Oosterwijk, Sebastian Vanek, Jens Altmann, Heliosa G Santos, Jeske J T van Harssel, Thomy de Ravel, Andrew O M Wilkie, Andreas Gal, Stefan Mundlos
Journal: Nature Genetics (2009)
In Ten Years
Authors: Warren W. Furey
Journal: Annals of Internal Medicine (1995)

Ad Libitum1 September 1995In Ten YearsWarren W. Furey, MDWarren W. Furey, MDChicago, IL 60611Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-5-199509010-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I want to be in an office seeing patients who trust me, and listen to what I say, and whom I want to see, and whom I want to help, andI want to listen to them and examine them and learn from them and counsel them as to change in lifestyle, tests they need to have done andI want to interpret those tests and to treat problems I find without concern for how they will pay for my advice, or the tests or the medicines and… I can't really ensure that they can afford to eat or ... Author, Article, and Disclosure InformationAffiliations: Chicago, IL 60611 Previousarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1995Volume 123, Issue 5Page: 389KeywordsChildrenComputers ePublished: 15 August 2000 Issue Published: 1 September 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Is Capsule Endoscopy Indicated in Patients with Hereditary Hemorrhagic Telangiectasia and Normal Esophagoduodenoscopy Findings?
Authors: M. Jimenez-Saenz, A. Caunedo-Alvarez, R. Romero-Castro, B. Maldonado-Pérez, J. Herrerias-Gutierrez
Journal: Endoscopy (2005)

We read with interest the recent report by Ingrosso et al. [1], concerning the value of capsule endoscopy in patients with hereditary hemorrhagic telangiectasia (HHT). It represents a valuable effort to evaluate the diagnostic yield of this novel endoscopic tool in a specific disease, that is so frequently associated with acute or chronic anemia of obscure origin. According to their results, use of this new technique will probably change the etiological diagnosis of occult bleeding in HHT and may also be able to alter treatment strategies in HHT patients with gastrointestinal bleeding. Furthermore, capsule endoscopy will overcome the limitation of angiography in those patients without overt active bleeding.
Rhabdomyolysis From Heat Hyperpyrexia
Authors: Jeffrey Mason
Journal: JAMA (1976)

HEAT STROKE, if it occurs following strenuous exercise, particularly in unacclimatized individuals, may be complicated by rhabdomyolysis and hypocalcemia.<sup>1</sup>Under these circumstances, serum phosphorus levels have often been elevated. We report a patient in whom heat stroke and myoglobinuria in the absence of renal failure were associated with substantial hypocalcemia and hypophosphatemia. <h3>Report of a Case</h3> In July 1974, a 51-year-old woman was hospitalized after she was found in a stuporous state. During the previous six days, the maximum ambient temperatures had been from 32 to 37 C, with high relative humidity. Two days before admission, the patient had seen her doctor for nonspecific body pains; he prescribed propoxyphene hydrochloride (Darvon), a combination of butalbital, caffeine, aspirin, and phenacetin (Fiorinal), and a meprobamate and benactyzine hydrochloride combination (Deprol). She habitually took cyanocobalamin and prochlorperazine (Compazine), and one tablet of a combination of secobarbital sodium and amobarbital sodium (Tuinal) before
The Causes of Epilepsy: Common and Uncommon Causes in Adults and Children
Authors: Victoria S. S. Wong
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Fine-Particle Humidifiers
Authors: Hans G. Grieble, F. Rosemary Colton, Thomas J. Bird, Angelo Toigo, Louis G. Griffith
Journal: New England Journal of Medicine (1970)

In a pulmonary-disease ward containing a respiratory-disease intensive-care unit, 9 per cent of the patients on the ward and one fifth to one third of those in the intensive-care unit harbored Pseudomonas aeruginosa in their respiratory tracts. Eight patients acquired pseudomonas pulmonary infections in the hospital. The fine-particle aerosol from unheated room humidifiers (Walton "centrifugal atomizer," Model HA) was shown to cause heavy environmental contamination by Ps. aeruginosa. Air sampling by the settling plate method yielded 300 gram-negative bacteria, including pseudomonas, per square foot per minute. Pyocin typing was used to identify the endemic strains of pseudomonas in reservoir water, in room air and in the sputum of patients with chronic respiratory disease. Each of four respirators in the intensive-care unit propagated 6 × 106 organisms per day. Decontamination of humidifiers by various means was unsatisfactory, and their use was discontinued.
The effect of cardiac contraction on collateral resistance in the canine heart.
Authors: J M Downey, R W Chagrasulis
Journal: Circulation Research (1976)

We determined whether the coronary collateral vessels develop an increased resistance to blood flow during systole as does the cognate vascular bed. Collateral resistance was estimated by measuring retrograde flow rate from a distal branch of the left anterior descending coronary artery while the main left coronary artery was perfused at a constant pressure. Retrograde flow rate was measured before and during vagal arrest. We found that in 10 dogs the prolonged diastole experienced when the heart was stopped caused no significant change in the retrograde flow rate, which indicated that systole has little effect on the collateral resistance. However, when left ventricular end-diastolic pressure was altered by changing afterload or contractility, a direct relationship between end-diastolic pressure and collateral resistance was noted.
Risk for Cerebral Palsy in Infants With Total Serum Bilirubin Levels at or Above the Exchange Transfusion Threshold
Authors: Yvonne W. Wu, Michael W. Kuzniewicz, Andrea C. Wickremasinghe, Eileen M. Walsh, Soora Wi, Charles E. McCulloch, Thomas B. Newman
Journal: JAMA Pediatrics (2015)

Exchange transfusion is recommended for newborns with total serum bilirubin (TSB) levels thought to place them at risk for cerebral palsy (CP). However, the excess risk for CP among these infants is unknown.To quantify the risks for CP and CP consistent with kernicterus that are associated with high TSB levels based on the 2004 American Academy of Pediatrics exchange transfusion threshold (ETT) guidelines.We enrolled 2 cohorts from a population of 525,409 infants in the Late Impact of Getting Hyperbilirubinemia or Phototherapy (LIGHT) birth cohort. Eligible infants were born at a gestational age of at least 35 weeks at 15 hospitals within the Kaiser Permanente Northern California integrated medical care delivery system from January 1, 1995, through December 31, 2011.The exposed cohort included all 1833 infants with at least 1 TSB measurement at or above the ETT based on age at testing, gestational age, and results of direct antiglobulin testing. The unexposed cohort was a 20% random sample of 104 716 infants with TSB levels below the ETT.A pediatric neurologist blinded to the TSB levels reviewed medical records to determine the presence of CP, defined as a nonprogressive congenital motor dysfunction with hypertonia or dyskinesia. Cerebral palsy was judged to be consistent with kernicterus if magnetic resonance imaging of the brain revealed bilateral globus pallidus injury in the setting of dyskinetic CP.We identified CP in 7 of 1833 exposed (0.4%) vs 86 of 104 716 unexposed (0.1%) infants (relative risk, 4.7 [95% CI, 2.2-10.0]). Absolute risk differences were 0.2% (95% CI, 0%-0.5%) for a TSB level 0 to 4.9 mg/dL above the ETT (n = 1705), 0.9% (95% CI, 0.1%-5.3%) for a TSB level 5.0 to 9.9 mg/dL above the ETT (n = 102), and 7.6% (95% CI, 2.1%-24.1%) for a TSB level 10 mg/dL or more above the ETT (n = 26). Cerebral palsy consistent with kernicterus occurred in 3 infants (incidence, 0.57 per 100,000 births); all 3 had TSB levels of more than 5.0 mg/dL above the ETT and at least 2 risk factors for neurotoxicity, such as prematurity, glucose-6-phosphate dehydrogenase deficiency, or hypoxia-ischemia.Cerebral palsy consistent with kernicterus occurred only in infants with 2 or more risk factors for neurotoxicity and TSB levels of more than 5 mg/dL above the ETT. Among infants with lower degrees of TSB level elevation, the excess risk for CP is minimal.
Tetanus of the Newborn
Authors: Harold Klingler
Journal: JAMA (1971)

To the Editor.—  Prevention of Neonatal Tetanus Through Immunization of Mother ( 217 :1558, 1971) prompts the following comment.  Tetanus neonatorum had been a problem in Alabama for many years. In 1969, we inaugurated an immunization program for the mother during her prenatal course in an effort to offer a temporary passive immunity to her infant to be born. Since the directive was sent to all county health departments and practicing physicians, the incidence of tetanus neonatorum has declined to zero. We feel that this program has saved the lives of several babies each year.  The directive, distributed statewide, reads as follows:  In view of the fact that the State of Alabama, Bureau of Vital Statistics, records an average of about 10 cases of tetanus neonatorum each year and since this is a preventable disease and it is felt there are few complications involved in an immunization program against tetanus, it
Cost Effectiveness of Tissue Plasminogen Activator
Authors: Thomas H. Lee
Journal: New England Journal of Medicine (1995)

Not so long ago, therapies that led to a survival advantage in randomized trials were quickly endorsed and adopted. The costs required to achieve the clinical benefit were of only minimal interest to the primary decision makers — physicians seeking the best outcomes for their patients. And in that era there would have been little controversy over whether tissue plasminogen activator (t-PA) is a more effective thrombolytic agent than intravenous streptokinase. Laboratory and clinical studies show that t-PA opens coronary arteries occluded by thrombus more rapidly than streptokinase,1 and the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded . . .
Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobin
Authors: Hua Cao, George Stamatoyannopoulos
Journal: American Journal of Hematology (2006)

Abstract We investigated the induction of the human fetal globin gene using five potent histone deacetylase (HDAC) inhibitors: FK‐228, HC‐Toxin, Trichostatin, MS‐275, and Apicidin, using in vitro assays and cultures of primary human erythroblasts. The results showed that FK228 is the most potent inducer of fetal hemoglobin and exhibits its effects in picomolar concentrations. FK228 should be considered as a potential therapeutic for induction of fetal hemoglobin in patients with β chain hemoglobinopathies. Am. J. Hematol., 2006. © 2006 Wiley‐Liss, Inc.
GAHS TAHP: the glasgow alcoholic hepatitis score in the treatment of alcoholic hepatitis in practice
Authors: H. Lafferty, E. Watson, R. Hamid, J. Winter, J. Morris, A. Stanley, E. Forrest
Journal: Gut (2011)

<h3>Introduction</h3> Alcoholic hepatitis (AH) continues to be a frequent cause of alcohol related mortality. The Glasgow Alcoholic Hepatitis Score (GAHS) has not only been proposed as an accurate measure of prognosis, but also as a guide to therapeutic intervention. However these studies have been retrospective. The authors assessed the use of the GAHS in the management of unselected patients with AH. <h3>Methods</h3> 182 patients with a clinical diagnosis of AH were assessed prospectively (Group 1), and then compared with a historical control group (Group 2). All patients had an admission serum bilirubin greater than 80 μmol/l. No patients were Hepatitis C PCR positive or had presented with evidence of upper gastro-intestinal haemorrhage. The unit protocol was for treatment with prednisolone 40 mg or pentoxifylline 400 mg three times a day at the discretion of the responsible consultant when the GAHS was ≥9 in Group 1. No Group 2 patients received either prednisolone or pentoxifylline (Group 2). <h3>Results</h3> Overall 28-day survival figures for Group 1 and Group 2 were 150 (82.4%) and 129 (73.7%) respectively (p=0.03; HR 1.64 (1.06–2.56)). The respective 84-day survival rates were 126 (69.2%) and 119 (68%) (p=0.41; HR 1.17 0.806–1.70)). In Group 1, 96 patients developed a GAHS ≥9 during the first week of their hospital admission (58%). On comparison Group 1 and 2 patients with a GAHS&lt;9 had similar rates of survival at day 28 and 84. However differences were seen between patients with a GAHS ≥9. At 28 days the survival rates of Group 1 and Group 2 were 71% and 41% respectively (p=0.0002; HR 2.86 (1.64–3.18)). At 84 days the survival rates of the Group 1 and Group 2 were 54% and 37% respectively (p=0.008; HR 1.95 (1.19–3.18)). The improvement in outcome was more clearly seen in GAHS ≥9 patients who received treatment as per protocol (80 of 96: 83%). Reasons given for not receiving treatment were as follows: 10 suspected sepsis (confirmed: 3 SBP; 3 chest sepsis; 1 secondary peritonitis), 1 upper gastro-intestinal haemorrhage after admission and 1 patient9s condition deteriorated too rapidly to allow treatment to start. In 4 cases no reasons were given. <h3>Conclusion</h3> The GAHS can be used in clinical practice. A GAHS ≥9 identifies patients who may benefit from treatment.
Alexander Aitken Clark
Authors: S. Clark
Journal: BMJ (2009)

<h3>ABSTRACT</h3> Transcription and DNA damage repair act in a coordinated manner. The scaffolding protein Sin3B serves as a transcriptional corepressor of hundreds of cell-cycle-related genes. However, the role of Sin3B during the DNA damage response still remains unknown. Here, we show that Sin3B depletion delays the resolution of DNA double-strand breaks (DSBs) and sensitizes cells to diverse DNA-damaging agents, including cisplatin and doxorubicin. Furthermore, Sin3B is rapidly recruited to DNA damage sites and interacts with other DDR proteins. Mechanistically, Sin3B promotes non-homologous end joining DNA repair by directing the accumulation of MDC1 at DBSs. Altogether, our findings impute an unexpected function for the transcriptional co-repressor Sin3B as a gatekeeper of genomic integrity, and point to the inhibition of the Sin3B chromatin modifying complex as a novel therapeutic vulnerability in cancer cells.