Expression of Activation Antigen on Lymphocytes in the Acquired Immunodeficiency Syndrome
Authors: Elisabeth Paietta, Brian Saltzman, Robert S. Klein, Gerald H. Friedland, Peter H. Wiernik, Harald Stein
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 June 1986Expression of Activation Antigen on Lymphocytes in the Acquired Immunodeficiency SyndromeELISABETH PAIETTA, Ph.D., BRIAN SALTZMAN, M.D., ROBERT S. KLEIN, M.D., GERALD H. FRIEDLAND, M.D., PETER H. WIERNIK, M.D., HARALD STEIN, M.D.ELISABETH PAIETTA, Ph.D.Search for more papers by this author, BRIAN SALTZMAN, M.D.Search for more papers by this author, ROBERT S. KLEIN, M.D.Search for more papers by this author, GERALD H. FRIEDLAND, M.D.Search for more papers by this author, PETER H. WIERNIK, M.D.Search for more papers by this author, HARALD STEIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-6-890_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Since the demonstration that the human T-lymphotropic virus type III/lymphadenopathy virus (HTLV-III/LAV) is the likely cause of the acquired immunodeficiency syndrome (AIDS), it has become clear that susceptibility to, and clinical outcome from, infection vary. Among high-risk groups, not all persons are infected, and among those infected there appears to be a spectrum from apparently healthy through AIDS-related complex to AIDS (1). The reasons for certain exposed persons acquiring infection and for some infected persons becoming ill are not yet known.One cofactor postulated to be important is the activation of the immune system (2, 3). The...References1. GOEDERTBIGGARWEISS JRS. Three-year incidence of AIDS in five cohorts of HTLV-III-infected risk group members. Science. 1986;231:992-5. CrossrefMedlineGoogle Scholar2. FOLKSPOWELLLIGHTFOOTEBENNMARTINFAUCI TDMSMA. Induction of HTLV-III/LAV from a nonvirus-producing T-cell line: implications for latency. Science. 1986;231:600-2. CrossrefMedlineGoogle Scholar3. ZAGURYBERNARDLEONARD DJR. Long-term cultures of HTLV-III-infected T cells: a model of cytopathology of T-cell depletion in AIDS. Science. 1986;231:850-3. CrossrefMedlineGoogle Scholar4. STEINMASONGERDES HDJ. The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood. 1985;66:848-58. CrossrefMedlineGoogle Scholar5. KLEINHARRISBUTKUS SMALLMOLLLESSERFRIEDLAND RCCBMG. Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome. N Engl J Med. 1984;311:354-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influxAugmentation of natural cytotoxicity by leucine enkephalin in cultured peripheral blood mononuclear cells from patients infected with human immunodeficiency virusPsoriatic arthritis and acquired immunodeficiency syndromePsoriasis, Gamma-Interferon, and the Acquired Immunodeficiency SyndromeDIETMAR FUCHS, Ph.D., ARNO HAUSEN, Ph.D., GILBERT REIBNEGGER, D.Sc., ERNST R. WERNER, D.Sc., MANFRED P. DIERICH, M.D., HELMUT WACHTER, Ph.D.Diminished Interferon Gamma Production May Be the Earliest Indicator of Infection with the Human Immunodeficiency Virus 1 June 1986Volume 104, Issue 6Page: 890-891KeywordsAIDSAIDS related complexAntigensHuman t lymphotropic virusImmune systemLymphocytes Issue Published: 1 June 1986 PDF DownloadLoading ...