Ranitidine-Warfarin Interaction
Authors: Anne M. Baciewicz
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 January 1990Ranitidine-Warfarin InteractionAnne M. Baciewicz, PharmD, Peter J. Morgan, MDAnne M. Baciewicz, PharmD, Peter J. Morgan, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-1-76_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:We report a possible prolongation of prothrombin time (PT) of warfarin by ranitidine. A 65-year-old woman with a past medical history of a cerebral vascular accident and an aortic valve replacement was discharged from the hospital with a diagnosis of recurrent deep-vein thrombosis, recurrent gastrointestinal bleeding, and iron-deficiency anemia. Four days before discharge, the ranitidine dose was increased to 600 mg daily because on the recommended 300-mg daily maintenance dose for several months the patient developed recurrent gastrointestinal bleeding. At discharge, her medications (all taken orally) included warfarin, 5 mg once daily; ranitidine, 300 mg twice daily;...References1. SaxRandolphPeace MWK. Effect of two cimetidine regimens on prothrombin time and warfarin pharmacokinetics during long-term warfarin therapy. Clin Pharmacol. 1987;6:492-5. Google Scholar2. ToonHopkinsGarstangRowland SKFM. Comparative effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of warfarin in man. Eur J Clin Pharmacol. 1987;32:165-72. CrossrefMedlineGoogle Scholar3. O'Reilly R. Comparative interaction of cimetidine and ranitidine with racemic warfarin in man. Arch Intern Med. 1984;144:989-91. CrossrefMedlineGoogle Scholar4. DesmondMashfordMarmanMorphettBreenWang PMPBKY. Decreased oral warfarin clearance after ranitidine and cimetidine. Clin Pharmacol Ther. 1984;35:338-41. CrossrefMedlineGoogle Scholar5. SerlinSibeonBreckenridge MRA. Lack of effect of ranitidine on warfarin action. Br J Clin Pharmacol. 1981;12:791-4. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University Hospitals of Cleveland Cleveland, OH 44106 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCoumarin anticoagulantsResponsiveness to low-dose warfarin associated with genetic variants of VKORC1, CYP2C9, CYP2C19, and CYP4F2 in an Indonesian populationANTICOAGULANTS, THROMBOLYTIC AGENTS, AND ANTI-PLATELET DRUGSCoumarin anticoagulantsINTERACTIONS OF WARFARINConcomitant Digoxin Toxicity and Warfarin Interaction in a Patient Receiving ClarithromycinTreatment of multiple sclerosis with high-dose corticosteroids may prolong the prothrombin time to dangerous levels in patients taking warfarinDrugs affecting blood coagulation and hemostasisThe drug interaction potential of ranitidine: An updateHistamine 2 -Receptor AntagonistsDrug Interactions and Adverse Reactions 1 January 1990Volume 112, Issue 1Page: 76-77KeywordsAortic valve replacementHemorrhageIron deficiency anemiaProthrombin timeThrombosis Issue Published: 1 January 1990 PDF DownloadLoading ...