tbuckley/cabot-search huggingface dataset:
The relationship between atrial and ventricular rates in patients with complete heart block.
Authors: T J Bayley, K D Lee
Journal: Thorax (1969)

The Upper Triassic rocks of the New York-New Jersey-Pennsylvania and Connecticut Valley belts, generally considered to be deposits of isolated basins, are inferred to represent remnants of the filling of an elongate rift valley that was 50 to 70 mi wide. In addition, the stratigraphic thickness of the Triassic rocks is hold to be approximately 30,000 ft. If these 2 conclusions are correct, then Late Triassic tectonic history is considerably more complex than previously thought and can be subdivided into 4 episodes. Episode 1: Initial graben subsidence without folds; deposition of 30,000 ft of nonmarine sediments; extrusive and intrusive igneous activity. Episode 2: Longitudinal crustal arching in center of initial graben; uplift, inversion of topography, and reversal of drainage; erosion; central parts of pre-Triassic graben floor ultimately elevated more than 30,000 ft; no igneous activity or transverse folds. Episode 3: Second-generation graben subsidence, development of transverse folds NE. of Hunterdon Plateau, New Jersey, with maximum structural relief exceeding 30,000 ft; no igneous activity. Episode 4: Offsetting of transverse folds by faults, some with strike-slip displacement of up to 12 mi; development of longitudinal Valley-and-Ridge type folds SW. of Hunterdon Plateau during strike-slip faulting; injection of porphyritic dolerite dikes into faults; formation of mineral deposits along faults. Extensive erosion took place after episode 4 until the transgressive Coastal Plain marine overlap in the Late Cretaceous, which buried some Triassic rocks. The Triassic structures are inferred to have involved the entire thickness of the crust and to have been controlled by subcrustal processes, the Triassic rocks themselves merely reacting passively. If the magnitude and complexity of Triassic tectonic history advocated here are correct, then the following regional geologic implications are also suggested: 1) Much of the high structural position and uncovering of Precambrian basement rocks in the medial Appalachians took place in the Late Triassic. 2) Large Triassic faults probably extend well beyond the limits of Triassic outcrop belts, as, for example, along the straight western boundary of the Taconic allochthon in the Hudson Valley. 3) The southward disappearance of the Taconic allochthon in the Hudson Valley may be due to uplift on the Late Triassic transverse Danbury anticline and subsequent erosion. 4) Many rocks now at the surface have been deeply buried. 5) Triassic igneous rocks were emplaced at different ages which bracket the tectonic episodes. If different radiometric ages could be detected between syndepositional and late postdepositional igneous rocks, then some estimate might be made of the time required for deformation. 6) Some Appalachian drainage may have originated on the flanks of the Late Triassic longitudinal crustal arch.
Short- Versus Long-Term Duration of Dual-Antiplatelet Therapy After Coronary Stenting
Authors: Marco Valgimigli, Gianluca Campo, Monia Monti, Pascal Vranckx, Gianfranco Percoco, Carlo Tumscitz, Fausto Castriota, Federico Colombo, Matteo Tebaldi, Giuseppe Fucà, Moh'd Kubbajeh, Elisa Cangiano, Monica Minarelli, Antonella Scalone, Caterina Cavazza, Alice Frangione, Marco Borghesi, Jlenia Marchesini, Giovanni Parrinello, Roberto Ferrari
Journal: Circulation (2012)

The optimal duration of dual-antiplatelet therapy and the risk-benefit ratio for long-term dual-antiplatelet therapy after coronary stenting remain poorly defined. We evaluated the impact of up to 6 versus 24 months of dual-antiplatelet therapy in a broad all-comers patient population receiving a balanced proportion of Food and Drug Administration-approved drug-eluting or bare-metal stents.We randomly assigned 2013 patients to receive bare-metal, zotarolimus-eluting, paclitaxel-eluting, or everolimus-eluting stent implantation. At 30 days, patients in each stent group were randomly allocated to receive up to 6 or 24 months of clopidogrel therapy in addition to aspirin. The primary end point was a composite of death of any cause, myocardial infarction, or cerebrovascular accident. The cumulative risk of the primary outcome at 2 years was 10.1% with 24-month dual-antiplatelet therapy compared with 10.0% with 6-month dual-antiplatelet therapy (hazard ratio, 0.98; 95% confidence interval, 0.74-1.29; P=0.91). The individual risks of death, myocardial infarction, cerebrovascular accident, or stent thrombosis did not differ between the study groups; however, there was a consistently greater risk of hemorrhage in the 24-month clopidogrel group according to all prespecified bleeding definitions, including the recently proposed Bleeding Academic Research Consortium classification.A regimen of 24 months of clopidogrel therapy in patients who had received a balanced mixture of drug-eluting or bare-metal stents was not significantly more effective than a 6-month clopidogrel regimen in reducing the composite of death due to any cause, myocardial infarction, or cerebrovascular accident.URL: http://www.clinicaltrials.gov. Unique identifier: NCT00611286.
Responses of the Ballistocardiogram in Hypertensive Patients to the Acute Administration of Apresoline, Hexamethonium, Veratrone, Regitine and Sodium Amytal
Authors: DAN C. ROEHM, ROSS C. KORY, GEORGE R. MENEELY
Journal: Circulation (1953)

Acute ballistocardiographic responses to five hypotensive drugs have been evaluated in 15 patients with essential hypertension in conjunction with depressor effects. In the majority of experiments qualitative and quantitative ballistocardiographic improvement paralleled the pressure reductions. On occasion the reverse was true. Inferences were drawn from these reactions based on the pharmacodynamics of the drugs. Because of the fundamental nature of the ballistic record, it is concluded that the capacity of the hypertensive heart to respond ballistocardiographically to a depressor agent permits a useful evaluation of its functional reserve and aids in a more physiologic selection of a hypotensive agent.
Differences in mite fauna between the continental and Mediterranean climates of Croatia: microscopy and Dustscreen<sup>TM</sup> test findings
Authors: J Macan, B Kanceljak, D Plavec, S Milković‐Kraus
Journal: Allergy (2003)

The aim of this study was to evaluate the difference between the mite fauna in the inland and coastal Croatia.Ninety-nine floor house dust samples were collected: 28 from the coastal area, 31 from the inland rural and 40 from the inland urban area. Data on basic household characteristics were collected for 81 of 99 households. The mites were separated from the dust using the floatation method and then microscopically identified. The levels of Dermatophagoides pteronyssinus (Der p) 1, Dermatophagoides farinae (Der f) 1 and Der 2 were measured using the Dustscreen test. Ordinal descriptive statistics and nonparametric tests were used for data analysis, assuming statistical significance at P < 0.05.More than 70% of mites identified in all areas were pyroglyphids. Nonpyroglyphid mites accounted for 20-25% of all identified mites in the coastal areas (Blomia, Lepidoglyphus and Glycyphagus) and with 15% in the inland areas (Lepidoglyphus and Acarus). The highest Der p 1 median levels were found in the coastal area, with significantly lower levels in the inland rural and inland urban areas (4.5; 2; 0.85 microg/g of dust; P = 0.0001). The highest Der f 1 median levels were found in the inland urban area, with significantly lower levels in the inland rural and coastal areas (0.88; 0.75; 0 microg/g of dust; P = 0.0013). The levels of Der f 1 were significantly higher in samples taken from households with central heating than from those with traditional heating (1; 0.25 microg/g of dust; P < 0.01).Separate diagnostic dust mite lists for the coastal and inland areas because of climatic and dwelling differences required to be implemented. Compared with traditional heating, central heating significantly increases the risk of exposure to Der f 1 levels >2 microg/g of dust (odds ratio, 7.35; 95% confidence interval, 1.43-37.87; P = 0.01).
FDG PET/CT as a Prognostic Test After 90Y Radioembolization in Patients With Metastatic Hepatic Disease
Authors: Martina Zalom, Run Yu, Marc Friedman, Catherine Bresee, Alan Waxman
Journal: Clinical Nuclear Medicine (2012)

The purpose of this study was to determine FDG PET/CT utility in predicting patient outcome undergoing Y RE for metastatic liver tumors.Thirty-one patients with metastatic tumors to the liver underwent Y RE between March 15, 2007, and May 5, 2011, at our institution. FDG PET/CT imaging was performed on each patient within 3 months before and after undergoing Y RE. Pretreatment and posttreatment FDG PET/CT were evaluated for SUV, number of liver lesions, and presence of disease outside the liver. The Kaplan-Meier method and Cox proportional hazard modeling was used to evaluate if SUV was a predictor of overall survival.Of the 31 patients, 12 were alive at the end of the study; median survival was 9 months (95% confidence interval, 7-18 months). The 24-month survival rate was 0.28 (95% confidence interval, 0.12-0.48). Kaplan-Meier analysis of preprocedure FDG PET/CT imaging showed no difference in rates of survival by number of lesions observed in the liver (P = 0.114) or presence of disease observed outside the liver (P = 0.719). Cases with new lesions outside the liver after treatment had significantly shorter survival times than cases without new lesions outside the liver (P = 0.002). Cox proportional hazard model showed that SUV levels before and after treatment were not significant predictors of overall survival.The appearance of new lesions outside the liver on FDG PET/CT within 3 months after Y RE was the only statistically significant variable in predicting poor outcome. Absence of new lesions outside the liver on postprocedure FDG PET/CT imaging helps identify patients achieving long-term survival.
The Oedipus Papers
Authors: Stuart M. Finch
Journal: JAMA (1989)

This book is a series of 27 chapters by almost as many authors dealing with the various aspects and interpretations of the Oedipus complex. As is fitting, it begins with a part of Freud's<i>Interpretation of Dreams</i>. Freud himself as well as others felt that the Oedipus complex formed the cornerstone of the foundations of psychoanalysis itself. Evidence of this view actually arose when Freud wrote to Fleiss about a year and a half after the death of Fleiss' father and subsequently wrote about it in the<i>Interpretation of Dreams</i>in 1900. In his readings Freud had come across Sophocles' three works on Oedipus,<i>Antigone, Oedipus Tyrannus</i>, and<i>Oedipus at Colonus</i>. The main thrust of Freud's thinking was on<i>Oedipus Tyrannus</i>. To most people the story of Oedipus is simple. He was an infant who was abandoned by his parents, was adopted into another family, reached manhood, and subsequently killed
"Missed pill" conception: fact or fiction?
Authors: P Bye
Journal: BMJ (1985)

oversimplification of the risks of extravasation.In the illustrative case the extravasation most probably occurred from the proximally situated venepuncture sites, a documented but not widely appreciated risk.Finally, the parochial nature of the President Truman "quotation" belies the extent of the problem.Extravasations are by no means the exclusive preserve of radiography departments.We constructed this lesson because of our con- cern over the number of extravasation injuries which we are seeing.Are such injuries avoidable?We believe so, if clinicians are ever alert to the risks and take the necessary steps to minimise them.DARBURD
Contribution of Plasma Protease Inhibitors to the Inactivation of Kallikrein in Plasma
Authors: Marc Schapira, Cheryl F. Scott, Robert W. Colman
Journal: Journal of Clinical Investigation (1982)

Although C̄l-inhibitor (C̄l-INH) and α2-macroglobulin (α2M) have been reported as the major inhibitors of plasma kallikrein in normal plasma, there is little quantitative support for this conclusion. Thus, we studied the inactivation of purified kallikrein in normal plasma, as well as in plasma congenitally deficient in C̄l-INH, or artificially depleted of α2M by chemical modification of the inhibitor with methylamine. Under pseudo-first-order conditions, the inactivation rate constant of kallikrein in normal plasma was 0.60 min−1. This rate constant was reduced to 0.35, 0.30, and 0.06 min−1, in plasma deficient respectively in C̄l-INH, α2M, or both inhibitors. Thus C̄l-INH (42%) and α2M (50%) were found to be the major inhibitors of kallikrein in normal plasma. Moreover all the other protease inhibitors present in normal plasma contributed only for 8% to the inactivation of the enzyme. To confirm these kinetic results, 125I-kallikrein (Mr 85,000) was completely inactivated by various plasma samples, and the resulting mixtures were analyzed by gel filtration on Sepharose 6B CL for the appearance of 125I-kallikrein-inhibitor complexes. After inactivation by normal plasma, 52% of the active enzyme were found to form a complex (Mr 370,000) with C̄l-INH, while 48% formed a complex (Mr 850,000) with α2M. After inactivation by C̄l-INH-deficient plasma, >90% of the active 125I-kallikrein was associated with α2M. A similar proportion of the label was associated with C̄l-INH in plasma deficient in α2M. After inactivation by plasma deficient in both C̄l-INH and α2M, 125I-kallikrein was found to form a complex of Mr 185,000. This latter complex, which may involve antithrombin III, α1-protease inhibitor, and/or α1-plasmin inhibitor, was not detectable in appreciable concentrations in the presence of either C̄l-INH or α2M, even after the addition of heparin (2 U/ml). These observations demonstrate that C̄l-INH and α2M are the only significant inhibitors of kallikrein in normal plasma confirming previous predictions based on experiments in purified systems. Moreover, in the absence of either C̄l-INH or α2M, the inactivation of kallikrein becomes almost entirely dependent on the other major inhibitor.
SEVERE EYE SYMPTOMS DUE TO DYEING THE EYELASHES
Authors: Oliver P. Bourbon
Journal: JAMA (1933)

As dyeing the eyelashes is a new fad of beauty parlor patrons, I am reporting this case for the purpose of calling attention to its dangerous possibilities. I have seen but one similar report.<sup>1</sup> The dye used in this case has for its trade mark "Larieuse," is called "Godefroy's French Coloring for Hair and Beard," and is manufactured by the Godefroy Manufacturing Company, St. Louis. The statement is made on the container that it is "compounded according to the French formula." It is also stated that "the dye is somewhat perishable and must be consumed within fifteen months from the date stamped below," the expiration date for this particular bottle being May 15, 1933. The dye was used in this case on July 8, 1933, almost two months after the expiration date which the manufacturers had marked on the bottle; but whether the age of the dye had anything
Failing to act on climate change will "cause great suffering," doctors warn
Authors: M. Limb
Journal: BMJ (2014)

The world is largely ill prepared for the future risks of a changing climate that will affect everyone on the planet, according to a major scientific review.

A report by the Intergovernmental Panel on Climate Change (IPCC) said that climate change was already having a “substantial” and “wide-ranging” effect on all continents and across all oceans.1 But the report warned that continuing global warming would pose a bigger risk of floods, food shortages, threats to human health, people’s livelihoods, and security unless carbon emissions were reduced.

“Increasing magnitudes of warming increase the likelihood of severe and pervasive impacts that may be surprising or irreversible,” it said.

The UN panel’s working group II report, Climate Change 2014: Impacts, Adaptation and Vulnerability …
Protection for Vaccinated Arms.
Authors: H. L. Green
Journal: JAMA (1894)

Mt. Pleasant, Iowa, April 17, 1894. <h3>To the Editor:</h3> —In our "Correspondence " of theJournal, February 24, I hoped as a result of it to elicit some ideas, either suggestive or final, of value in the direction aimed; and perhaps also, that some one would bring up the subject for the same purpose next June, at the meeting of theAmerican Medical Association. Of the former, there has been no result. Of the latter, it is yet too early to know what may be done. Having myself concluded my opinion of the best plan of protection to the vaccinated—the subject we have in consideration—I will advance it; and also as a reason for this second communication. Cut two triangles out of any piece of cloth which may be at hand; a lesser triangle cut from the base of the first and larger triangle, and you have a V, the first
Abstract 3798: P53R2 regulates oxidative phosphorylation complexII and III in keeping integrity of mitochondrial function
Authors: LiJun Xue, Mei-Ling Kuo, Xiyong Liu, Linling Chen, Bingsen Zhou, Yun Yen
Journal: Cancer Research (2011)

Abstract It has been reported that there is a direct correlation between severe muscle mitochondrial DNA depletion and functionally important mutations in p53R2 in a number of children with mitochondrial depletion syndrome. However, there is no clear evidence how p53R2 involves in the regulation on mitochondrial function. Our current study demonstrated that p53R2 knock-down MCF7 and IMR90 cells displayed low expression level of core proteins in oxidative phosphorylation (OXPHOS) complex II, III, but not complex I, IV or V. Correspondently, activity of complex II and ATP quantity from p53R2-knockdown cells decreased significantly comparing to control cells expressing non-silencing short-hairpin RNA. Moreover, mitochondrial superoxide level increased in p53R2-knockdown cells, which was consistent with the notion that dysfunction of OXPHOS complex II and/or III generated toxic reactive oxygen species in mitochondria. The increased superoxide was not due to SOD2 degradation, since SOD2 expression level was unchanged in IMR90 and MCF7 cells following knockdown of p53R2. These results indicate that down-regulation of p53R2 reduces OXPHOS complex II and III protein expression and correspondent activity. The compromised complex II and III in electron transport chains thus result in premature electron leakage to oxygen to form superoxide in the mitochondria. These observations suggest that p53R2 might protect mitochondria through maintaining integrity of electron transport chains coupling with oxidative phosphorylation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3798. doi:10.1158/1538-7445.AM2011-3798
Test based on natural processes cannot be patented, rules US court
Authors: C. Dyer
Journal: BMJ (2012)

The US Supreme Court has ruled as invalid two patents on a test that helps doctors determine drug dosage for autoimmune disorders such as Crohn’s disease, in a landmark decision that will affect the growing field of personalised medicine.

The justices ruled unanimously that patents on a test developed by Prometheus Laboratories were invalid because they were based on the laws of nature.

The test was designed to find out the level of thiopurine that should be administered to an individual patient: too much might be toxic, …
Career preferences of doctors who qualified in the United Kingdom in 1993 compared with those of doctors qualifying in 1974, 1977, 1980, and 1983
Authors: T. W Lambert, M. J Goldacre, C. Edwards, J. Parkhouse
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objective</b>: To report the career preferences of doctors who qualified in the United Kingdom in 1993 and to compare their choices with those of earlier cohorts of qualifiers. <b>Design</b>: Postal questionnaires with structured questions, including questions about choice of future long term career, were sent to doctors a year after qualification. <b>Setting</b>: United Kingdom. <b>Subjects</b>: All medical qualifiers of 1993, comparing their replies with those from earlier studies of the qualifiers of 1974, 1977, 1980, and 1983. <b>Main outcome measures</b>: Choice of future long term career and certainty of choice expressed at the end of the first year after qualification. <b>Results</b>: Questionnaires were sent to 3657 doctors. 2621 (71.7%) replied. Of the 2621 respondents, 70.5% (1849) stated that their first preference was for a career in hospital practice, 25.8% (677) specified general practice, 1.0% (25) specified public health medicine or community health, 1.4% (36) specified careers outside medicine, and 1.3% (34) did not state a choice. By contrast, 44.7% (1416/3168) of the doctors in the 1983 cohort had specified that their first preference was general practice. Among the 1993 qualifiers, general practice was the first career choice of 17.5% of men (227/1297) and 34.0% of women (450/1324). Only 7.4% of men (96/1297) stated that they definitely wanted to enter general practice. Only 7.8% (103/1324) of women qualifiers in 1993 expressed a career preference for surgical specialties. Within hospital practice, comparing 1993 with 1983, choices for the medical specialties and for accident and emergency medicine rose and those for pathology fell. Women were less definite than men about their choice of future long term career. <b>Conclusions</b>: If the 1993 cohort is typical of the current generation of young doctors, there has been a substantial shift away from general practice as a career choice expressed at the end of the preregistration year. General practice was much more popular among women than men. Few women opted for surgery. The sex imbalance in the percentage of doctors who choose different mainstreams of medical practice seems set to continue.