Rheumatoid Arthritis and Its Systemic Manifestations
Authors: CARL M. PEARSON
Journal: Annals of Internal Medicine (1966)

The UCLA Interdepartmental Conference1 November 1966Rheumatoid Arthritis and Its Systemic ManifestationsCARL M. PEARSON, M.D., F.A.C.P., EUGENE BARNETT, M.D., RICHARD KROENING, M.D., LEONARD MARMOR, M.D., JOHN F. MURRAY, M.D., JAMES B. PETER, M.D., PH.D., ALLEN SALICK, M.D.CARL M. PEARSON, M.D., F.A.C.P.Search for more papers by this author, EUGENE BARNETT, M.D.Search for more papers by this author, RICHARD KROENING, M.D.Search for more papers by this author, LEONARD MARMOR, M.D.Search for more papers by this author, JOHN F. MURRAY, M.D.Search for more papers by this author, JAMES B. PETER, M.D., PH.D.Search for more papers by this author, ALLEN SALICK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-5-1101 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Carl M. Pearson: Rheumatoid arthritis (RA) is not merely a disease of joints and periarticular tissues; it is rather—as we shall try to demonstrate today—a systemic disease. Its articular manifestations are usually most prominent and produce the greatest amount of discomfort and disability, but they are not lethal. On the other hand, the many and varied systemic manifestations of rheumatoid disease may involve nearly any or every bodily organ or system, and some can be fatal. The rheumatic diseases are closely allied to the other collagen or connective tissue diseases, such as systemic lupus erythematosus (SLE), scleroderma, dermatomyositis, polymyositis,...References1. MIKKELSEN WM: The epidemiology of rheumatic diseases, in Arthritis and Allied Conditions, edited by HOLLANDER, J. L. Lea & Febiger, Philadelphia, 1966, p. 551. Google Scholar2. IRBYADAMSTOONE RRAEC: Peripheral neuritis associated with rheumatoid arthritis. Arthritis Rheum. 1: 44, 1958. CrossrefMedlineGoogle Scholar3. BUNIMBURCHO'BRIEN JJTAWM: Influence of genetic and environmental factors on the occurrence of rheumatoid arthritis and rheumatoid factor in American Indians. Bull. Rheum. Dis. 15: 349, 1964. MedlineGoogle Scholar4. SHORTBAUERREYNOLDS CLWWE: Rheumatoid Arthritis. Harvard University Press, Cambridge, 1957. CrossrefGoogle Scholar5. SINCLAIRCRUICKSHANK RJR: A clinical and pathological study of sixteen cases of rheumatoid arthritis with extensive visceral involvement ('rheumatoid disease'). Quart. J. Med. 25: 313, 1956. MedlineGoogle Scholar6. BYWATERS EG: Peripheral vascular obstruction in rheumatoid arthritis and its relationship to other vascular lesions. Ann. Rheum. Dis. 16: 84, 1957. CrossrefMedlineGoogle Scholar7. CARRMAYNE DTJG: Pleurisy with effusion in rheumatoid arthritis, with reference to the low concentration of glucose in pleural fluid. Amer. Rev. Resp. Dis. 85: 345, 1962. MedlineGoogle Scholar8. BRANNANGOODDIVERTIEBAGGENSTOSS HMCAMBAH: Pulmonary disease associated with rheumatoid arthritis. JAMA 189: 914, 1964. CrossrefMedlineGoogle Scholar9. GOTTLIEBSPIERATEIRSTEINSILTZBACH AJHASLE: Serologic factors in idiopathic diffuse interstitial pulmonary fibrosis. Amer. J. Med. 39: 405, 1965. CrossrefMedlineGoogle Scholar10. ROBERTSONBRINKMAN JLGL: Nodular rheumatoid lung disease. Amer. J. Med. 31: 483, 1961. CrossrefMedlineGoogle Scholar11. CAPLAN A: Certain unusual radiological appearances in the chest of coal-miners suffering from rheumatoid arthritis. Thorax 8: 29, 1953. CrossrefMedlineGoogle Scholar12. PRICESKELTON TMMO: Rheumatoid arthritis with lung lesions. Thorax 11: 234, 1956. CrossrefMedlineGoogle Scholar13. HEIMERLEVIN RM: Gamma1A and gamma2 rheumatoid factors. Arthritis Rheum. 7: 738, 1964. Google Scholar14. BARNETTNORTHCONDEMIJACOXVAUGHN EVAFJJRFJH: Antinuclear factors in systemic lupus erythematosus and rheumatoid arthritis. Ann. Intern. Med. 63: 100, 1965. LinkGoogle Scholar15. BARNETTBIENENSTOCKBLOCH EVJKJ: Antinuclear factors in synovial fluid: possible participants in the rheumatoid inclusion body. JAMA. In press. Google Scholar16. HARRISVAUGHAN JJH: Transfusion studies in rheumatoid arthritis. Arthritis Rheum. 4: 47, 1961. CrossrefMedlineGoogle Scholar17. MARMONT AM: The transfusion of active LE plasma into nonlupus recipients, with a note on the LE-like cell. Ann. N. Y. Acad. Sci. 124: 838, 1965. CrossrefMedlineGoogle Scholar18. WARDCLOUDTURNER JRRSLM: Non-cytotoxicity of "nuclear antibodies" from lupus erythematosus sera in tissue culture. Ann. Rheum. Dis. 23: 381, 1964. CrossrefMedlineGoogle Scholar19. BARNETTCONDEMILEDDYVAUGHN EVJJJPJH: Gamma-2, gamma-1A and gamma-1M antinuclear factors in human sera. J. Clin. Invest. 43: 1104, 1964. CrossrefMedlineGoogle Scholar20. WEISSMAN G: Lysosomes, autoimmune phenomena, and diseases of connective tissue Lancet 2: 1373, 1964. CrossrefMedlineGoogle Scholar21. HOLLANDERMCCARTYASTORGACASTRO-MURILLO JLDJGE: Studies on the pathogenesis of rheumatoid joint inflammation. I. The "R.A. Cell" and a working hypothesis. Ann. Intern. Med. 62: 271, 1965. LinkGoogle Scholar22. PEKINZVAIFLER TJNJ: Hemolytic complement in synovial fluid. J. Clin. Invest. 43: 1372, 1964. CrossrefMedlineGoogle Scholar23. HEDBERG H: The depressed synovial complement activity in adult and juvenile rheumatoid arthritis. Acta Rheum. Scand. 10: 109, 1964. CrossrefMedlineGoogle Scholar24. FOSTIROPOULOSAUSTENBLOCH GKFKJ: Total hemolytic complement (CH50) and second component of complement (C2 hu) activity in serum and synovial fluid. Arthritis Rheum. 8: 219, 1965. CrossrefMedlineGoogle Scholar25. MALININPEKINZVAIFLERBAUER TITJNJH: Intra-cytoplasmic and extracellular particles in rheumatoid synovial fluids. Arthritis Rheum. 7: 743, 1964. Google Scholar26. ZVAIFLER NJ: A speculation on the pathogenesis of joint inflammation in rheumatoid arthritis. Arthritis Rheum. 8: 289, 1965. CrossrefMedlineGoogle Scholar27. ASTORGABOLLET GAJ: Diagnostic specificity and possible pathogenetic significance of inclusions in synovial leucocytes. Ibid., p. 511. Google Scholar28. PETERPEARSONMARMOR JBCML: Erosive osteoarthritis of the hands. Arthritis Rheum. 9: 365, 1966. CrossrefMedlineGoogle Scholar29. SHERMAN MS: The non-specificity of synovial reactions. Bull. Hosp. Joint Dis. 12(2): 110, 1951. MedlineGoogle Scholar30. KIDDPETER KLJB: Erosive osteoarthritis. Radiology 86: 640, 1966. CrossrefMedlineGoogle Scholar31. : A seven-day variability study of 499 patients with peripheral rheumatoid arthritis. Arthritis Rheum. 8: 302, 1965. CrossrefMedlineGoogle Scholar32. : Gold therapy in rheumatoid arthritis; final report of a multicentre controlled trial. Ann. Rheum. Dis. 20: 315, 1961. CrossrefMedlineGoogle Scholar33. MAINLANDSUTCLIFFE DMI: Hydroxychloroquine sulfate in rheumatoid arthritis, a six-month, double-blind trial. Bull. Rheum. Dis. 13: 287, 1962. Google Scholar34. MAINLANDSUTCLIFFE DMI: Aspirin in rheumatoid arthritis, a seven-day double-blind trial—preliminary report. Bull. Rheum. Dis. 16: 388, 1965. MedlineGoogle Scholar35. MARMOR L: The role of hand surgery in rheumatoid arthritis. Surg. Gynec. Obstet. 116: 335, 1963. Google Scholar36. MARMOR L: Surgical treatment for arthritic deformities of the hands. Clin. Orthop. 39: 171, 1965. MedlineGoogle Scholar37. MARMOR L: Surgical treatment of chronic arthritis. Mod. Treatm. 1: 1313, 1964. MedlineGoogle Scholar38. MARMOR L: Surgical treatment of the rheumatoid hand. Proc. Roy. Soc. Med. 58: 567, 1965. CrossrefMedlineGoogle Scholar39. FLATT AE: Salvage of the rheumatoid hand. Clin. Orthop. 23: 207, 1962. MedlineGoogle Scholar40. CLAYTON ML: Surgery of the forefoot in rheumatoid arthritis. Clin. Orthop. 16: 136, 1960. MedlineGoogle Scholar41. MARMOR L: Surgery of the rheumatoid foot. Surg. Gynec. Obstet. 119: 1009, 1964. MedlineGoogle Scholar42. LONDON PS: Synovectomy of the knee in rheumatoid arthritis; an essay in surgical salvage. J. Bone Joint Surg. [Brit.] 37: 392, 1955. CrossrefMedlineGoogle Scholar43. MARMOR L: Synovectomy of the rheumatoid knee. Clin. Orthop. 44: 151, 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CARL M. PEARSON, M.D., F.A.C.P.; EUGENE BARNETT, M.D.; RICHARD KROENING, M.D.; LEONARD MARMOR, M.D.; JOHN F. MURRAY, M.D.; JAMES B. PETER, M.D., PH.D.; ALLEN SALICK, M.D.Affiliations: Los Angeles, CaliforniaThis is an edited transcription of an Interdepartmental Clinical Case Conference arranged by the Department of Medicine, UCLA School of Medicine, Los Angeles, Calif.Requests for reprints should be addressed to Dr. Carl M. Pearson, Department of Medicine, UCLA School of Medicine, Los Angeles, Calif. 90024. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRheumatology in GeriatricsRheumatology in GeriatricsOrganic brain syndrome in rheumatoid arthritis following corticosteroid withdrawalAntibodies to dna in patients with rheumatoid arthritis and juvenile rheumatoid arthritisCase 2-1975Pregnancy, rheumatoid arthritis, and intrauterine growth retardationIntraspinal Rheumatoid Nodule Causing Nerve Root CompressionCerebral Vasculitis Visualized by Angiography in Juvenile Rheumatoid Arthritis Simulating Brain TumorTHE ONSET OF RHEUMATOID ARTHRITIS IN THE AGED 1 November 1966Volume 65, Issue 5Page: 1101-1130KeywordsAntigensConnective tissue diseasesPolymyositisRheumatic feverRheumatoid arthritisSclerodermaSystemic diseasesSystemic lupus erythematosusThrombosisVasculitis ePublished: 1 December 2008 Issue Published: 1 November 1966 PDF downloadLoading ...