Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular Risk
Authors: Jeff Gulcher
Journal: Annals of Internal Medicine (2009)

Letters19 May 2009Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular RiskJeff Gulcher, MD, PhD and Kari Stefansson, MD, PhDJeff Gulcher, MD, PhDFrom deCODE Genetics, Reykjavik 110, Iceland.Search for more papers by this author and Kari Stefansson, MD, PhDFrom deCODE Genetics, Reykjavik 110, Iceland.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-10-200905190-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Paynter and colleagues (1) showed that the widely replicated 9p21 genetic risk factor affected risk in the Women's Genome Health Study, largely independent of traditional risk factors. They were able to reliably measure this genetic marker years after patient recruitment because DNA is invariant, in contrast to such biomarkers as C-reactive protein (CRP). The power to detect improvement in cardiovascular event prediction by adding a new risk factor to traditional risk factors depends on the total number of events in the study. The Women's Genome Health Study recruited women of mean age 52 years who had low ...References1. Paynter NP, Chasman DI, Buring JE, Shiffman D, Cook NR, Ridker PM. Cardiovascular disease risk prediction with and without knowledge of genetic variation at chromosome 9p21.3. Ann Intern Med. 2009;150:65-72. [PMID: 19153409] LinkGoogle Scholar2. Brautbar A, Ballantyne C, Lawson K, Nambi V, Chambless L, Folsom A, et al. Abstract 5050: impact of adding a single allele in the 9p21 locus to traditional risk factors on risk classification for coronary heart disease and implications for lipid-modifying therapy in the white population of the Atherosclerosis Risk in Communities (ARIC) study. Circulation. 2008;118 Suppl S-1143. Google Scholar3. Talmud PJ, Cooper JA, Palmen J, Lovering R, Drenos F, Hingorani AD, et al. Chromosome 9p21.3 coronary heart disease locus genotype and prospective risk of CHD in healthy middle-aged men. Clin Chem. 2008;54:467-74. [PMID: 18250146] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Jeff Gulcher, MD, PhD; Kari Stefansson, MD, PhDAffiliations: From deCODE Genetics, Reykjavik 110, Iceland.Disclosures:Employment: J. Gulcher (deCODE Genetics), K. Stefansson (deCODE Genetics). Stock ownership or options (other than mutual funds): J. Gulcher (deCODE Genetics), K. Stefansson (deCODE Genetics). PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCardiovascular Disease Risk Prediction With and Without Knowledge of Genetic Variation at Chromosome 9p21.3 Nina P. Paynter , Daniel I. Chasman , Julie E. Buring , Dov Shiffman , Nancy R. Cook , and Paul M. Ridker Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular Risk Lukasz Kiljanek Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular Risk John R. Schwarzenbach Questions About Genetic Variation in 9p21 as a Predictor of Cardiovascular Risk Nina P. Paynter , Nancy R. Cook , and Paul M Ridker Metrics 19 May 2009Volume 150, Issue 10 Page: 736 Keywords C-reactive proteins Cells Cholesterol Genetics Hypercholesterolemia Longitudinal studies Low density lipoprotein Medical risk factors Prospective studies Risk management ePublished: 19 May 2009 Issue Published: 19 May 2009 Copyright & PermissionsCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...