tbuckley/cabot-search huggingface dataset:
Direct Measurement of Bronchial Arterial Flow
Authors: BRUNO HORISBERGER, SIMON RODBARD
Journal: Circulation Research (1960)

A method is described for the measurement of the collateral pulmonary blood flow in the thoracotomized dog by utilization of a flow-meter which measures flow into an aortic sac from which the bronchial arteries arise. This preparation maintains the normal perfusing pressures and diminishes phase changes in the arterial pulse waves. The bronchial vascular resistance is increased by an increase in the insufflation air pressure, by bilateral vagotomy, or by the administration of l -epinephrine into the bronchial arterial circulation. The bronchial vascular resistance was decreased after a transitory interruption of the bronchial arterial blood flow (reactive hyperemia). After administration of serotonin in the bronchial artery, a transient increase in resistance was followed by a marked decrease. Intrapulmonary vascular injections produced only a decrease in resistance. The present data demonstrate the sensitivity of the preparation described.
HISTORY OF THE MEDICAL DEPARTMENT IN THE WORLD WAR
Authors: George H. Carter
Journal: JAMA (1923)

To  Editor:  —In  review of The Medical Department of  United States Army in  World War (The Journal, September 22), it is stated that the United States Medical History of  World War is limited to an edition of about 3,000, and that it will be available only to libraries and institutions.  Your attention is called to  fact that, in anticipation of an additional demand for this publication,  Superintendent of Documents of this office, who is authorized by law to print copies of publications for sale, ordered a supply for this purpose, and can now furnish Vol. 15, Anthropology, for $1.75 per copy. Similar sales arrangements will be made for  succeeding volumes.
Aspirin Prevents <b> <i>Escherichia coli</i> </b> Lipopolysaccharide– and <b> <i>Staphylococcus aureus</i> </b> –Induced Downregulation of Endothelial Nitric Oxide Synthase Expression in Guinea Pig Pericardial Tissue
Authors: Maria M. Arriero, Juan C. de la Pinta, Marta Escribano, Angel Celdrán, Luis Muñoz-Alameda, Joaquin García-Cañete, Ana M. Jiménez, Santos Casado, Jerónimo Farré, Antonio López-Farré
Journal: Circulation Research (2002)

The aim was to analyze whether pericardial tissue expresses endothelial NO synthase (eNOS) protein and to determine the presence of cytosolic proteins that bind to eNOS mRNA. The effect of aspirin on the above-mentioned parameters was also analyzed. eNOS protein was expressed in pericardial tissue from male guinea pigs. Escherichia coli lipopolysaccharide (LPS, 10 microgram/mL) and Staphylococcus aureus endotoxin (SA, 10 microgram/mL) reduced eNOS protein expression and shortened the half-life of the eNOS messenger. Under basal conditions, cytosolic extracts from pericardial samples bound to the 3'-untranslated region (3'-UTR) of eNOS mRNA, which was enhanced by LPS and SA. Proteinase K fully prevented the binding of cytosolic pericardial extracts to 3'-UTR of eNOS mRNA, suggesting the involvement of proteins that were further characterized as 60- and 51-kDa proteins. Aspirin (1 to 10 mmol/L) restored eNOS expression in either LPS- and SA-stimulated pericardial samples and reduced the binding activity of the pericardial cytosolic proteins to 3'-UTR of eNOS mRNA. Indomethacin also reduced the downregulation of eNOS by LPS and diminished the binding activity of the cytosolic proteins, although higher doses of indomethacin than of aspirin were needed to improve these parameters. In conclusion, eNOS protein is expressed in guinea pig pericardial tissue. LPS and SA stimulate the binding activity of pericardial cytosolic proteins to 3'-UTR of eNOS mRNA and reduce eNOS protein expression. High doses of aspirin and indomethacin protect eNOS protein expression and reduce the binding activity of the cytosolic proteins to 3'-UTR of eNOS mRNA, suggesting an inverse association between the presence of these cytosolic proteins and eNOS expression.
Predicting Survival in Pulmonary Arterial Hypertension
Authors: Raymond L. Benza, Dave P. Miller, Mardi Gomberg-Maitland, Robert P. Frantz, Aimee J. Foreman, Christopher S. Coffey, Adaani Frost, Robyn J. Barst, David B. Badesch, C. Gregory Elliott, Theodore G. Liou, Michael D. McGoon
Journal: Circulation (2010)

Background— Factors that determine survival in pulmonary arterial hypertension (PAH) drive clinical management. A quantitative survival prediction tool has not been established for research or clinical use. Methods and Results— Data from 2716 patients with PAH enrolled consecutively in the US Registry to Evaluate Early and Long-Term PAH Disease Management (REVEAL) were analyzed to assess predictors of 1-year survival. We identified independent prognosticators of survival and derived a multivariable, weighted risk formula for clinical use. One-year survival from the date of enrollment was 91.0% (95% confidence interval [CI], 89.9 to 92.1). In a multivariable analysis with Cox proportional hazards, variables independently associated with increased mortality included pulmonary vascular resistance &gt;32 Wood units (hazard ratio [HR], 4.1; 95% CI, 2.0 to 8.3), PAH associated with portal hypertension (HR, 3.6; 95% CI, 2.4 to 5.4), modified New York Heart Association/World Health Organization functional class IV (HR, 3.1; 95% CI, 2.2 to 4.4), men &gt;60 years of age (HR, 2.2; 95% CI, 1.6 to 3.0), and family history of PAH (HR, 2.2; 95% CI, 1.2 to 4.0). Renal insufficiency, PAH associated with connective tissue disease, functional class III, mean right atrial pressure, resting systolic blood pressure and heart rate, 6-minute walk distance, brain natriuretic peptide, percent predicted carbon monoxide diffusing capacity, and pericardial effusion on echocardiogram all predicted mortality. Based on these multivariable analyses, a prognostic equation was derived and validated by bootstrapping technique. Conclusions— We identified key predictors of survival based on the patient’s most recent evaluation and formulated a contemporary prognostic equation. Use of this tool may allow the individualization and optimization of therapeutic strategies. Serial follow-up and reassessment are warranted. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00370214.
Aplastic Anaemia in Simmonds's Disease
Authors: A. Bloom, C. C. Bryson
Journal: BMJ (1948)

MEDITJOHRNAL 75 already red and injected, the attempt was abandoned.The abdomen was then closed without drainage.Next day she was much better.Morphine and progesterone were given daily in an attempt to postpone labour, but four days after the operation labour started, and she was delivered spontaneously of a living child weighing 6 lb.(2.7 kg.) after an easy labour lasting 17 hours.She did not complain unduly of any discomfort in the abdominal wound.Her subsequent progress was uneventful.A test meal in the puerperium revealed marked hyperchlorhydria, and a barium meal six weeks after the operation showed that the ulcer was still active and there was some delay in emptying.She was discharged to continue medical treatment, but further surgical measures may be necessary at some future date.
Advanced gastric adenocarcinoma mimicking a submucosal tumor
Authors: F. Teraishi, F. Uno, S. Kagawa, T. Fujiwara, A. Gouchi, N. Tanaka
Journal: Endoscopy (2007)

A 63-year-old asymptomatic man was admitted for evaluation of a gastric lesion incidentally noted on upper gastrointestinal endoscopic examination during a routine health evaluation. At initial endoscopy, a 13-mm submucosal tumor covered with benign-appearing mucosa was found ([Figure 1]). Endoscopic ultrasonography (EUS) demonstrated a 13.0-mm homogenous, circumscribed hypoechogenic lesion rising from the fourth sonographic layer, and this lesion was thought from its morphology to be muscularis propria ([Figure 2]). Initial biopsy specimens were negative for any neoplastic degeneration. Follow-up endoscopy with mucosal biopsy was performed 13 months after the initial examination. This revealed that the margin of the tumor had become irregular, and the central erythema was more prominent ([Figure 3]). The specimens taken from the central depression revealed poorly differentiated adenocarcinoma. At laparotomy, serous surface invasion was strongly suspected on the gastric wall although no ascites or liver metastasis were present. Distal gastrectomy with regional lymph node dissection, cholecystectomy, and gastroduodenostomy were performed. The histopathologic specimen was consistent with moderately differentiated adenocarcinoma, partially mixed with poorly differentiated adenocarcinoma, without focal lymph or vascular invasion. The tumor extended to the subserosa but did not involve the serosa ([Figures 4 a, b]). All dissected lymph nodes were free of tumor.
Diseases of the Liver and Biliary System
Authors: Harry B. Greenberg
Journal: JAMA (1969)

<h3>Diseases of the Liver,</h3> edited by William T. Foulk, 140 pp, with illus, $10, New York: Blakinston Division. McGraw-Hill Book Co., 1968. "One unit blood transfusions are never necessary." This parenthetic statement from the chapter on viral hepatitis reflects the straightforward tone of the fourth edition of Dr. Sherlock's comprehensive book. Subject matter is frequently condensed, facts are easily retrieved. The investigator will find ample reference to world literature of the 1960's and before. For information concerning diagnosis, prognosis, and treatment, the practitioner probably need look no further. The book is notably readable. Occasional historical asides orient the reader toward changing terminology and concept. Electron microscopic findings occupy a prominent place. Diagrams, pictures of gross specimens, and intelligible photomicrographs illustrate most pathologic changes described in the text. Thorough discussions of hepatic disease include indications for radiographic and radioisotope study and emphasize the use of serumenzyme changes, electrophoretic patterns, immunoglobulin estimations,
In the Vertical Transmission of HIV, Timing May Be Everything
Authors: Philip A. Pizzo, Karina M. Butler
Journal: New England Journal of Medicine (1991)

The significance of understanding the vertical transmission of HIV lies in the 78% of women's AIDS cases (1991) of sexually active women who may transmit the infection to their offspring. 2% of children in the US and 5-25% of children in developing countries are HIV infected. The current rates of maternal-fetal transmission average 25-30%. Interrupting this mode of passage would provide protection for children. The Van de Perre study on postnatal transmission by breast feeding is discussed in order to the timing of HIV infection and the relationship to infant risk of infection. Postnatal infection of infants suggests that the risk is enhanced during the primary infection of the mother. It is pointed out that transient but large elevations in plasma virus titers have been observed during primary infection of homosexual men, before anti-p24 and anti-gp160 antibodies appear. These plasma titers may increase the efficiency of vertical transmission. It is also possible that the absence of neutralizing or nonneutralizing antibodies may enhance transmission. The frequency of new infections is estimated by Van de Perre in the rate of seroconversion in Rwandan women as 4.7-7.3%/year. The US rate is .6-.8/1000/year for all adults and adolescents. Pregnancy can occur after primary HIV infection or at the onset when plasma titers are high and antibody levels are low. It is reported that the rate of transmission may be highest when mothers are in a more advanced disease state. Another factor affecting transmission is the presence or absence of maternal antibodies. Lower HIV transmission may be related to the presence of epitopes on the hypervariable V3 loop of HIV gp120 or the principal neutralizing domain. Although HIV virus has been identified in fetal tissues after 8-15 weeks gestation, there is reason to believe that the greatest transmission is intrapartum because maternal blood may be ingested or there is maternal-fetal transfusion during labor and delivery. New York studies have suggested that 50% of infected infants of known seropositive women will be positive by the polymerase chain reaction by 3 months of age and 50% by 3-6 months of age. It is likely that the delay is due to infection late in gestation.
Specific antibodies to moesin, a membrane-cytoskeleton linker protein, are frequently detected in patients with acquired aplastic anemia
Authors: Hiroyuki Takamatsu, Xingmin Feng, Tatsuya Chuhjo, Xuzhang Lu, Chiharu Sugimori, Katsuya Okawa, Miyuki Yamamoto, Shoichi Iseki, Shinji Nakao
Journal: Blood (2006)
Psychothérapie de groupe en hôpital psychiatrique à sécurité maximale
Authors: Jean-Marie Delacroix
Journal: Psychotherapy and Psychosomatics (1978)

Research Articles| February 16 2010 Psychothérapie de groupe en hôpital psychiatrique à sécurité maximale Subject Area: Psychiatry and Psychology Jean-Marie Delacroix Jean-Marie Delacroix Institut Philippe Pinel, Montréal, P.Q. Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1978) 29 (1-4): 130–136. https://doi.org/10.1159/000287113 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Jean-Marie Delacroix; Psychothérapie de groupe en hôpital psychiatrique à sécurité maximale. Psychother Psychosom 31 December 1978; 29 (1-4): 130–136. https://doi.org/10.1159/000287113 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1978Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
874. Prolonged Adenovirus and Adeno-Associated Virus-Mediated Gene Delivery to Rabbit Iliac Arteries Using Gene-Eluting Stents: A Direct Comparison
Authors: Faisal Sharif, Sean Hynes, Jill McMahon, James Crowley, Kieran Daly
Journal: Molecular Therapy (2006)

Introduction: Gene eluting stents are now being evaluated in animals as an alternative approach to inhibiting in stent restenosis. AAV and particularly adenovirus are commonly used for gene transfer applications. However, it is unknown whether these vectors can be eluted from a stent over a prolonged period. We tested the hypothesis that these vectors can achieve a prolonged and localized gene delivery to vessel wall using stents as delivery platform. Methods: AdβGal and AAV2βGal at a concentration of 5 × 109 pfu and 5.3 × 109 drp respectively were used to coat BiodivYsio Hi Matrix stents. Gene transfer was assessed at five time points (3, 7, 14, 21, 28 days) using X-gal staining. After balloon injury, 3.0/11 mm stents were deployed in the external iliac arteries of NZW rabbits. 21 stents were used in the adenovirus group and 23 stents were used in the AAV group. 8 PC coated stents were used as controls. RT-PCR was used to assess distal spread of virus in multiple organs (n=6). Results: Expression of LacZ was demonstrated with both vectors at all time points. In the adenovirus group mean percentage of cells expressing transgene at 3 days was 5.15% which increased gradually to a mean expression of 9.85% at 28 days (p>0.005). Expression was localized to medial cells at 3 day, but it was predominantly seen in the neointimal cells at 28 days. In the AAV group 3 day expression was 8.45% which gradually decreased to 1.73% at 28day (p<0.005). Gene transfer was also confirmed in both groups on histological sections. No systemic dissemination of virus was seen in any group. Conclusion: Adenovirus and AAV2-coated stents can be used to deliver genes for up to 28 days. Expression was seen in the medial and in neointimal cells. These vectors can be used to target the blood vessel wall in order to reduce the incidence of in stent restenosis.
A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.
Authors: S Yonehara, A Ishii, M Yonehara
Journal: The Journal of Experimental Medicine (1989)

We have prepared an mAb specific for a human cell surface component (termed anti-Fas mAb). Anti-Fas shows cell-killing activity that is indistinguishable from the cytolytic activity of TNF. Fas antigen was characterized by western blotting, indicating that Fas antigen is a cell surface protein with a molecular weight of 200,000, which is different from the molecular weight of TNF-R. Fas antigen, however, is co-downregulated with the TNF-R when cells sensitive to the cytolytic activity of TNF are incubated with either TNF or anti-Fas. In contrast, Fas antigen on cells insensitive to TNF is not co-downregulated with the TNF-R. We suggest that the cell-killing activity of TNF is mediated by Fas antigen associated with the TNF-R.
The Cost-effectiveness of Antihypertensive Drugs-Reply
Authors: Lee Goldman
Journal: JAMA (1990)

<h3>In Reply. —</h3> Although Dr Kaplan is a distinguished contributor to the field of hypertension, we disagree strongly with his letter. First, our article explicitly addressed all of the major issues that he has raised. Second, his own treatment recommendations, regardless of the consensus on which they may be based, ignore the issue of cost. It is our contention that costs are extremely important in evaluating long-term therapy for an asymptomatic condition and must be considered in making any public health recommendations. We searched the literature for all studies in which placebo controls were used. We recognized the limitations of these studies in terms of the number of patients and the duration of follow-up. However, we also demonstrated convincingly that studies without placebo controls tend to overestimate greatly the antihypertensive effects of medications. We recognized that it is not certain whether blood pressure reductions will reduce coronary deaths, but we
Abstract 5488: Novel death pathway in a p53 null human leukemia cell line treated with PNC-27
Authors: Maly Fenelus, Sheena M. Mathew, Paul A. Zolkind, Victor Adler, Ehsan S. Yazdi, Josef Michl, Matthew R. Pincus, Wilbur B. Bowne
Journal: Cancer Research (2011)

Abstract Background: PNC-27 is a p53-derived peptide from the human double minute binding domain (HDM-2). This peptide has been shown to induce rapid tumor cell necrosis of selected cancer cells, while sparing their normal cellular counterparts (PNAS 2010; 107: 1918-1923). PNC-27 binds to HDM-2 in the cancer cell membrane, causing pore-formation and permeabilization of the membrane. We now propose an additional target for PNC-27 involving mitochondrial membrane-bound B-cell lymphoma-2 (Bcl-2), which contains a BH3 protein-protein interaction domain. BH3 serves as a potent mediator of cell death in pro-apoptotic proteins (such as Bax and Bad), as well as anti-apoptotic proteins, Bcl-2 and Bcl-XL. These Bcl-2 proteins have been proposed to control function and stability of the outer mitochondrial membrane. Methods: The anti-cancer activity and mechanism of PNC-27 (p53 aa12-26-penetratin) was studied against p53 null K562, a human leukemia cancer cell line. Necrosis was determined by measuring lactate dehydrogenase (LDH), while apoptosis was determined by measuring early markers of apoptosis (caspases 3, 7). Co-immunoprecipitation (IP) was performed between PNC-27 and subcellular components to identify potential targets for PNC-27 in K562 cells. HDM-2, Bcl-2, Cytochrome C, and ATP synthesis in PNC-27-treated cells were studied. Results: We found that PNC-27, but not control peptide PNC-29, is cytotoxic to K562 cells, inducing nearly 90% inhibition of proliferation with LDH release. PNC-27 peptide induced Cytochrome C release as well as downregulation of ATP synthesis. Furthermore, endoge$$nous HDM-2 and Bcl-2 was found to IP with exogenous PNC-27 in K562 cells, inducing downregulation of HDM-2 and Bcl-2. Conclusions: P53 N-terminal derived peptide (PNC-27) potentially alters the mitochondrial membrane of K562 cells via induction of outer membrane permeabilization; with resultant down-regulation of Bcl-2, induction of Cytochrome C release, and decreased ATP synthesis. Our results suggest a second target and mechanism of cell death using PNC-27 in a p53 null K562 cell line; a p53 derived peptide that also targets Bcl-2 leading to rapid tumor cell necrosis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5488. doi:10.1158/1538-7445.AM2011-5488
Dietary protein energy supplementation of pregnant Asian mothers at Sorrento, Birmingham. II: Selective during third trimester only.
Authors: O A Viegas, P H Scott, T J Cole, P Eaton, P G Needham, B A Wharton
Journal: BMJ (1982)

Unselective dietary protein energy supplementation of Asian mothers at Sorrento Maternity Hospital did not enhance intrauterine growth. The effect of selective supplementation was therefore studied. Forty-five mothers who at 28 weeks were known to be nutritionally at risk (triceps increment less than or equal to 20 microns/week between 18 and 28 weeks) received one of three supplements during the third trimester: (a) vitamins only--a multivitamin sachet daily containing vitamins A, B, C, and D; (b) energy--42-125 MJ (10 000-30 000 kcal), all from carbohydrate, plus vitamins; (c) protein energy--energy and vitamins as before, but with 5-10% of energy from milk protein. Eighty-three mothers regarded as adequately nourished at 28 weeks also received one of the three supplements. In the nutritionally at-risk mothers the protein energy supplement was associated with a heavier crude birth weight and heavier weight for gestational age. Supplementation did not lead to improved intrauterine growth in those mothers who were adequately nourished. The differential effect of supplementation depending on the mothers9 nutritional state during the second trimester may explain apparently conflicting results of other studies where some have shown a substantial effect of supplementation and others only a small effect. This effect of intervention is further evidence that "poor nutrition" contributes to poor intrauterine growth in selected mothers, even in developed countries.