tbuckley/cabot-search huggingface dataset:
Saxophonist's diverticulosis.
Authors: M J Shea
Journal: BMJ (1979)

treat local swelling with oral antihistamines.A patient with any systemic manifestations should be given a Medihaler-Epi as well as antihistamine tablets, although it is doubtful if any medication will be absorbed by the gastric mucosa after a sting.Although there may be few actual fatalities from insect stings, the number of nearfatalities and of incidents terrifying to patients and their relatives must, to judge by the number seen at our clinic, be high.Some attempt should therefore be made to protect acutely sensitive patients.The best method available at present is hyposensitisation and the pure venom extracts mentioned in your article should become available in a few weeks.
P756Invalidation of mouse QSOX1: consequences upon acute heart failure
Authors: A Caillard, N Vodovar, S Sadoune, M Meddour, A Mebazaa, Z Li, JL Samuel
Journal: Cardiovascular Research (2014)

QSOX1 was identified as a new biomarker of acute heart failure (AHF). Using a proteomics strategy on plasma, QSOX1, which exists in 2 isoforms (short S and long L form), emerged as a promising marker to differentiate dyspnea caused by AHF from other syndromes. Preliminary results from our group suggested a protective role of OSOX1 cardiac induction in AHF. We developed an AHF murine model by isoproterenol injections. To further study the role of QSOX1 during AHF, we used antisense oligonucleotides (AOs) and we generated a knock-out (KO) mouse for QSOX1. AHF was provoked by two daily injections of 150 mg/kg of Isoproterenol (ISO) for two days; control mice (C) received NaCl 0.09‰ injections. Mice were sacrificed the third day, after cardiac function has been assessed by echocardiography. To silence QSOX1 expression, mice were treated by intraperitoneal injection of antisense oligonucleotides (AOs) for QSOX1. QSOX1 cardiac expression was analyzed by RT-qPCR, immunoblotting and immonofluorescence. In parallel, embryonic stem cell clone QSOX1tm1a (KOMP), in which the QSOX1 gene is invalidated, were injected into mouse blastocysts (SEAT platform, France). The KO constructs contain a promoter-less lacZ gene that is under the control of the QSOX1 regulatory sequences. QSOX1+/- heterozygotes mice were obtained from chimeric mice. The ISO mice exhibited a decrease in shortening fraction (C = 35.0 ± 0.4 %; ISO = 27.2 ± 3.3 %; p<0,001), a left ventricular hypertrophy (C= 4.42 ± 0.2 mg/g; ISO= 5.34 ± 0.3 mg/g; p<0.001) and a pulmonary congestion evaluated with lung weight/body weight ratio (C= 5.24±0.08 mg/g; ISO= 6.10±0.22 mg/g; p<0.001). A cardiac induction of QSOX1 mRNA was observed in AHF mice (x2.1, p<0,01) concomitantly to BNP (x3, p<0,01). AOs treatment enhanced AHF signs in ISO mice (increase in pulmonary congestion p<0.05). QSOX1 gene invalidation is homozygous viable and fertile. Echocardiography measurements showed that adult mice had no cardiac morphological or vascular abnormality. At basal level, lacZ expression was elevated in the epididymis, trachea and arteries, as previously described. In the heart, we observed that after ISO injection, the decrease in shortening fraction as measured by echography was accompanied by an increase in lacZ expression in the cardiomyocytes. The data suggest that QSOX1 is a new biomarker of ADHF and plays a role in the process. The QSOX1 KO mouse model should help to define QSOX1 function in AHF.
Readmission Rates After Total Hip Arthroplasty—Reply
Authors: Peter Cram
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ethics of Renal Biopsies in Typhoid Fever
Authors: Visith Sitprija, Vichitra Pipatanagul, Vijitr Boonpucknavig, Somnate Boonpucknavig
Journal: Annals of Internal Medicine (1975)

Comments and CorrectionsJune 1, 1975Ethics of Renal Biopsies in Typhoid FeverVISITH SITPRIJA, M.D.PH.D., F.A.C.P., VICHITRA PIPATANAGUL, M.D., VIJITR BOONPUCKNAVIG, M.D., SOMNATE BOONPUCKNAVIG, M.D.VISITH SITPRIJA, M.D.PH.D., F.A.C.P.Search for more papers by this author, VICHITRA PIPATANAGUL, M.D.Search for more papers by this author, VIJITR BOONPUCKNAVIG, M.D.Search for more papers by this author, SOMNATE BOONPUCKNAVIG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-6-850_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In response to Dr. LoGerfo's comment (Ann Intern Med81:861, 1974) on the ethical aspect of renal biopsy study in typhoid fever done by our group (Ann Intern Med81:210-213, 1974) we wish to offer our reply.Our study was an attempt to further define the nature of typhoid fever, an apparently simple disease that needs more details in its description. It represented a model in man supporting the concept of pathogenesis of glomerulonephritis advanced from earlier studies in animals. It also brought up a hypothesis to explain proteinuria in febrile diseases long believed to be due... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics June 1, 1975Volume 82, Issue 6Page: 850-850KeywordsBiopsyGlomerulonephritisPathogenesisProteinuriaTyphoid Issue Published: June 1, 1975 PDF DownloadLoading ...
Prospective seroepidemiological study of role of human papillomavirus in non-cervical anogenital cancers
Authors: T. Bjorge, J. Dillner, T. Anttila, A. Engeland, T. Hakulinen, E. Jellum, M. Lehtinen, T. Luostarinen, J. Paavonen, E. Pukkala, M. Sapp, J. Schiller, L. Youngman, S. Thoresen
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objective:</b> To evaluate the association between infection with the major oncogenic types of human papillomavirus and the risk of developing non-cervical anogenital cancers in a cohort followed up prospectively. <b>Design:</b> Data from two large serum banks to which about 700 000 people had donated serum samples were followed up for a mean of 8 years. People who developed non-cervical anogenital cancers during follow up were identified by registry linkage with the nationwide cancer registries in Finland and Norway. Within this cohort a nested case-control study was conducted based on the serological diagnosis of infection with human papillomavirus types 16, 18, and 33. <b>Subjects:</b> 81 cases and 240 controls matched for sex, age, and storage time of serum samples. <b>Main outcome measures:</b> Odds ratios of developing non-cervical anogenital cancers in presence of IgG antibodies to specific micro-organisms. <b>Results:</b> Subjects seropositive for human papillomavirus type 16 had an increased risk of developing non-cervical anogenital cancers (odds ratio 3.1 (95% confidence interval 1.4 to 6.9)). Subjects seropositive for type 33 also had an increased risk (odds ratio 2.8 (1.0 to 8.3)) but not significantly after adjustment for infection with type 16. Seropositivity for human papillomavirus type 16 was associated with an increased risk of developing vulvar and vaginal cancers (odds ratio 4.5 (1.1 to 22)) and a strongly increased risk of developing preinvasive vulvar and vaginal lesions (odds ratio ∞ (3.8 to ∞)). Seropositivity for human papillomavirus type 18 increased the risk of developing preinvasive lesions (odds ratio 12 (1.2 to 590)). High, but non-significant odds ratios for types 16 and 33 were seen for penile cancers. <b>Conclusions:</b> This study provides prospective seroepidemiological evidence that infection with human papillomavirus type 16 confers an increased risk of developing non-cervical genital cancers, particularly vulvar and vaginal cancers. <h3>Key messages</h3> Human papillomavirus has emerged as a leading infectious cause of human cancer, notably cervical and other anogenital cancers, but prospective epidemiological evidence of causality is lacking This study used six million person years of follow up to investigate the relation between seropositivity for human papillomavirus and the development of non-cervical anogenital cancers Infection with human papillomavirus type 16 increases the risk of developing non-cervical genital cancers, particularly vulvar and vaginal cancers Infection with human papillomavirus type 16 should be considered in future intervention strategies for cervical and other genital cancers
Anomalous Attachment of Mitral Valve Causing Subaortic Atresia
Authors: KENNETH L. JUE, JESSE E. EDWARDS
Journal: Circulation (1967)

In a newborn female infant with persistent common atrioventricular canal, subaortic atresia resulting from attachment of the anterior mitral leaflet to the ventricular septum was observed. The cavity of the left ventricle was hypoplastic, while the wall was hypertrophied. The case illustrates the most severe degree of subaortic obstruction that may result from anomalous attachment of the mitral valve to the ventricular septum. Also present were multiple spleens, and other cardiovascular anomalies. The last included junction of a persistent left superior vena cava with the left atrium, absence of the coronary sinus, absence of the limbi of the fossa ovalis, and an anomalous connection of the right pulmonary veins to the right atrium.
An Analysis of Calibration and Discrimination Among Multiple Cardiovascular Risk Scores in a Modern Multiethnic Cohort
Authors: Andrew P. DeFilippis, Rebekah Young, Christopher J. Carrubba, John W. McEvoy, Matthew J. Budoff, Roger S. Blumenthal, Richard A. Kronmal, Robyn L. McClelland, Khurram Nasir, Michael J. Blaha
Journal: Annals of Internal Medicine (2015)

Accurate risk assessment of atherosclerotic cardiovascular disease (ASCVD) is essential to effectively balance the risks and benefits of therapy for primary prevention.To compare the calibration and discrimination of the new American Heart Association (AHA) and American College of Cardiology (ACC) ASCVD risk score with alternative risk scores and to explore preventive therapy as a cause of the reported risk overestimation using the AHA-ACC-ASCVD score.Prospective epidemiologic study of ASCVD.MESA (Multi-Ethnic Study of Atherosclerosis), a community-based, sex-balanced, multiethnic cohort.4227 MESA participants aged 50 to 74 years and without diabetes at baseline.Observed and expected events for the AHA-ACC-ASCVD score were compared with 4 commonly used risk scores-and their respective end points-in MESA after a 10.2-year follow-up.The new AHA-ACC-ASCVD and 3 older Framingham-based risk scores overestimated cardiovascular events by 37% to 154% in men and 8% to 67% in women. Overestimation was noted throughout the continuum of risk. In contrast, the Reynolds Risk Score overestimated risk by 9% in men but underestimated risk by 21% in women. Aspirin, lipid-lowering or antihypertensive therapy, and interim revascularization did not explain the overestimation.Comparability of MESA with target populations for primary prevention and possibility of missed events in MESA.Of the 5 risk scores, 4, including the new AHA-ACC-ASCVD score, showed overestimation of risk (25% to 115%) in a modern, multiethnic cohort without baseline clinical ASCVD. If validated, overestimation of ASCVD risk may have substantial implications for individual patients and the health care system.National Heart, Lung, and Blood Institute.
Compression fractures of the dorsal spine in hypoglycaemic fits in diabetes.
Authors: J D Nabarro
Journal: BMJ (1985)

Compression fractures of the dorsal spine in hypoglycaemic fits in diabetes Compression fractures of the bodies of the mid-dorsal vertebrae have been described in tetanus,' in convulsion therapy for mental illness,23 and in idiopathic epilepsy.4So far as I know they have never been reported after hypoglycaemic attacks in insulin treated diabetes.I have seen four such cases in the past eight years, in one of which the diagnosis was not at first recognised. Case reportsCase I-A man aged 48 had been diabetic since the age of 17 and was receiving a single injection of semilente and lente insulin.He had a nocturnal fit in which he bit his tongue and had pain in the upper part of his back.He came to hospital the next day, and x ray pictures showed a compression fracture of the bodies of T3 and T4 (figure).Case 1. Posteroanterior (left) and lateral (right) radiographs of dorsal spine showing compression fractures of T3 and T4.Case 2-A 30 year old man with a history of diabetes for two years and taking soluble and isophane insulin twice a day awoke at 5 30 am with severe pain in the upper back.He was brought to hospital as an emergency case and admitted to the orthopaedic ward with an unexplained compression fracture of T5 and T6.Case 3-A man of 35 had been diabetic for 22 years and was taking soluble and isophane insulin in the morning and soluble and ultralente insulin in the evening.He had a severe hypoglycaemic attack at 1 am and subsequently complained of backache.A rather prominent mid-dorsal vertebral spinous process was noted.Radiography showed a compression fracture of T7.Case 4-A man of 42 with an 11 year history of diabetes had been injecting insulin (Actrapid and Monotard) twice a day for seven years.One morning after his usual dose and before he had eaten his breakfast he became unconscious.He was found after five hours but despite treatment remained comatose for 24 hours.When he recovered he complained of pain in the mid-dorsal region and radiography showed compression of the bodies of T4 to T7.
The false breast: should we go for it so quickly?
Authors: J. Friedeberger
Journal: BMJ (1996)

When a woman loses a breast through mastectomy there is pain, anger at what has happened, fear of what may happen in the future, and grief at losing a part of her body. She may be dismayed, even horrified, when she looks at her wound. She may feel lopsided, diminished, disfigured, and socially and sexually unacceptable. Dealing with these overwhelming emotions takes time. But most women attempt to allay them by immediately opting for a prosthesis or reconstructive surgery, and in this they are often encouraged by their doctors.

I was not offered reconstruction and did not consider it. I was fitted for a prosthesis within four days of my mastectomy in November 1993. I have never worn it because by the time that I had found the right bra to go with it three months later I had grown comfortable with my …
Acid Suppression and Pneumonia
Authors: James C. Gregor
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ELECTROCONVULSIVE TREATMENT AND SEVERE CARDIOVASCULAR DISEASE
Authors: ROLAND M. ATKINSON, ROBERT T. RUBIN
Journal: American Journal of Psychiatry (1964)

Two psychotic patients with severe cardiovascular disease, in whom ECT was successfully used to treat the psychoses, are reported. The specific technique of ECT administration is outlined, including preparation of the treatment room and the patient. The indications for ECT in this category of patient and the rationale of the treatment technique are discussed. The need for careful pre-treatment evaluation and preparedness for cardiac emergencies is emphasized.
The association between BMI and mortality using offspring BMI as an indicator of own BMI: large intergenerational mortality study
Authors: G. Davey Smith, J. A. Sterne, A. Fraser, P. Tynelius, D. A Lawlor, F. Rasmussen
Journal: BMJ (2009)

<b>Objectives</b> To obtain valid estimates of the association between body mass index (BMI) and mortality by using offspring BMI as an instrumental variable for own BMI. <b>Design</b> Cohort study based on record linkage, with 50 years of follow-up for mortality. Associations of offspring BMI with all cause and cause specific maternal and paternal mortality were estimated as hazard ratios per standard deviation of offspring BMI. <b>Setting</b> A large intergenerational prospective population based database covering the general population of Sweden. <b>Participants</b> More than one million Swedish parent-son pairs. <b>Results</b> The final dataset analysed contained information on 1 018 012 mother-son pairs (122 677 maternal deaths) and 1 004 617 father-son pairs (242 126 paternal deaths). For some causes of death, the patterns of associations between offspring BMI and mortality were similar to those seen for own BMI and mortality in previous studies. Parental mortality from diabetes, coronary heart disease, and kidney cancer had the strongest positive associations with offspring BMI (for example, hazard ratio (HR) for coronary heart disease per standard deviation increase in offspring BMI for mothers 1.15, 95% CI 1.14 to 1.17 and for fathers 1.10, 1.09 to 1.11). However, in contrast to the inverse association of own BMI with lung cancer and respiratory disease mortality seen in other studies, there was a positive association between offspring BMI and lung cancer mortality in mothers (1.12, 1.09 to 1.15) and fathers (1.03, 1.02 to 1.05) and between offspring BMI and respiratory mortality in mothers (1.05, 1.02 to 1.08) and fathers (1.02, 1.00 to 1.04). Associations of own BMI and offspring BMI with all cause, cardiovascular disease related, and non-cardiovascular disease related mortality were compared in a subset of father-son pairs (n=72 815). When offspring BMI was used as an instrumental variable for paternal BMI, the causal association between BMI and paternal cardiovascular disease mortality (HR per standard deviation of BMI 1.82, 95% CI 1.17 to 2.83) was stronger than that indicated by the directly observed association between own BMI and cardiovascular disease mortality (1.45, 1.31 to 1.61). <b>Conclusions</b> Use of offspring BMI as a predictor of own BMI, a technique that avoids problems of reverse causality, suggests that positive associations of BMI with all cause and cardiovascular mortality may be underestimated in conventional observational studies. Use of offspring BMI instead of own BMI in analyses of respiratory disease and lung cancer mortality, for which previous studies have reported consistent and strong inverse associations with own BMI, suggests that such studies have overstated the apparent adverse consequences of lower BMI with respect to these outcomes.
Effect of Fluoroquinolone on the Enhanced Nitric Oxide-Induced Peripheral Vasodilation Seen in Cirrhosis
Authors: Jaye P.F. Chin-Dusting
Journal: Annals of Internal Medicine (1997)

Background: In patients with cirrhosis, portosystemic shunts allow intestinal bacteria and endotoxin to enter the systemic circulation. Endotoxemia may induce increased synthesis of nitric oxide, thereby contributing to arterial vasodilation. Objective: To test the hypothesis that the antibiotic norfloxacin blocks the effects of nitric oxide. Design: Placebo-controlled, double-blind, crossover study. Setting: Alfred Hospital, Melbourne, Australia. Patients: 9 patients with alcohol-related cirrhosis and 10 healthy controls. Intervention: Norfloxacin, 400 mg twice daily, for 4 weeks. Measurements: Peripheral blood flow was measured by using forearm venous occlusion plethysmography. Results: Basal forearm blood flow was higher in patients with cirrhosis than in controls (3.69 ± 0.27 mL/100mL per minute and 2.47 ± 0.40 mL/100mL per minute; P = 0.014) but returned toward normal after norfloxacin was given (2.64 ± 0.31 mL/100 mL of tissue per minute in patients with cirrhosis). Responses to NG -monomethyl-L-arginine were greater in patients with cirrhosis but returned to normal after norfloxacin was given. Conclusion: Bacterial endotoxemia in patients with cirrhosis induces increased synthesis of nitric oxide that can be corrected with norfloxacin.
Unravelling the mysteries of collagen and cicatrix after myocardial infarction
Authors: P. Whittaker
Journal: Cardiovascular Research (1995)

Journal Article Unravelling the mysteries of collagen and cicatrix after myocardial infarction Get access Peter Whittaker Peter Whittaker Heart Institute, The Hospital of the Good Samaritan, 1225 Wilshire Blvd, Los Angeles, CA 90017, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 29, Issue 6, June 1995, Pages 758–762, https://doi.org/10.1016/S0008-6363(96)88609-3 Published: 01 June 1995 Article history Received: 22 December 1994 Accepted: 27 February 1995 Published: 01 June 1995