tbuckley/cabot-search huggingface dataset:
Percutaneous endoscopic gastrostomy feeding.
Authors: S. Ghosh, M. A. Eastwood
Journal: BMJ (1992)

a conserved breast, although the definition of local recurrence does depend on the extent and meticulousness of histopathological examination.Wide excision to ensure clear margins certainly compromises cosmetic results, particularly in small breasts, and the relative importance of cosmesis and local recurrence needs to be determined for each patient.Adequate radiotherapy minimises the risk of local recurrence, and if there is local recurrence survival does not seem to be affected adversely.The effect of a booster dose of radiation in relation to completeness of excision is currently the subject of a clinical trial by the European Organisation for Research and Treatment ofCancer.
Xanthogranulomatous cholecystitis presenting with duodenal ulcer and cholecystoenteric fistula
Authors: C. Fu, T. Hsieh, D. Chan, H. Lee, T. Huang
Journal: Endoscopy (2012)

A 66-year-old woman presented with a nonhealing duodenal ulcer after undergoing Helicobacter pylori eradication therapy for 1 week and proton pump inhibitor treatment for 4 months. Repeat endoscopy showed the duodenal ulcer with a whitish mucous coating and some whitish discharge over the bulb. The mucous coating retracted upward with breathing ([Fig. 1]). Abdominal sonography revealed gallstones with an ill-defined gallbladder wall but no gallbladder distension. A computed tomography (CT) scan of the abdomen showed gallbladder stones with significant gallbladder wall thickening. The gallbladder wall had an indistinct border toward the liver and duodenal bulb. A coronal view showed duodenal wall thickening without lumen obstruction ([Fig. 2]). After admission, the patient's vital signs were stable, but physical examination showed mild tenderness over the epigastric region and an equivocal Murphy's sign. In addition to chronic cholecystitis with infiltration to the duodenum, gallbladder carcinoma with duodenal invasion was strongly suspected. The patient underwent surgical intervention and a cholecystoenteric fistula was noted. Pathological examination of specimens from the fistula showed aggregation of histiocytes with microvesicular foamy cytoplasm ([Fig. 3]). The final diagnosis was xanthogranulomatous cholecystitis with duodenal involvement.
Effectiveness of terbinafine in cutaneous alternariosis
Authors: L. Machet, M.C. Machet, L. Vaillant
Journal: British Journal of Dermatology (2000)

Journal Article Effectiveness of terbinafine in cutaneous alternariosis Get access L. Machet, L. Machet Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar M.C. Machet, M.C. Machet Pathology, University Hospital, F‐37044 Tours cedex 1, FranceE‐mail: machet@med.univ‐tours.fr Search for other works by this author on: Oxford Academic Google Scholar L. Vaillant L. Vaillant Departments of Dermatology and Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 5, 1 November 2000, Pages 1115–1116, https://doi.org/10.1046/j.1365-2133.2000.03873.x Published: 01 November 2000
THE REGULAR PROFESSION OF MEDICINE.
Authors: W. H. HAUGHEY
Journal: JAMA (1898)

The phosphate of lime is used to develop the osseous system which is now increasing rapidly.If there is a change or necessity to meet, nature modifies the food accordingly.In the case of the calf, colt, and animals which commence locomotion very soon after birth, where exercise is often very great, the nitrogenous principle of the milk is increased.This excess of casein is necessary on account of the excessive waste resulting from the extra exercise.Judging from these facts we would naturally, as the child grows older and exercises more, change the food, increasing the nitro- genous principle in proportion, to meet the resultant waste.A knowledge of physiology will enable us to select that kind of food which is demanded by the age, condition and temperature.Foods are usually divided into organic and inorganic.A very convenient subdi- vision is to divide the organic into first, nitrogenous; this embraces substances consisting of proteid, exam- ples of which are albumin, casein, myosin, gluten, fibrin, legumen, etc.; second, non-nitrogenous, these are: a, amyloid or saccharin bodies, sometimes called car- bohydrates; examples of these are starches and sugars; b, oils and fats, substances which contain carbon, hydrogen and oxygen, the oxygen being less than in the amyloids and saccharin bodies.Inorganic: first, foods which furnish to the system the required salts; second, liquid food, this is chiefly water.After we thoroughly understand the best diet
Chloroquine stimulates nitric oxide synthesis in murine, porcine, and human endothelial cells.
Authors: D Ghigo, E Aldieri, R Todde, C Costamagna, G Garbarino, G Pescarmona, A Bosia
Journal: Journal of Clinical Investigation (1998)

Nitric oxide (NO) is a free radical involved in the regulation of many cell functions and in the expression of several diseases. We have found that the antimalarial and antiinflammatory drug, chloroquine, is able to stimulate NO synthase (NOS) activity in murine, porcine, and human endothelial cells in vitro: the increase of enzyme activity is dependent on a de novo synthesis of some regulatory protein, as it is inhibited by cycloheximide but is not accompanied by an increased expression of inducible or constitutive NOS isoforms. Increased NO synthesis is, at least partly, responsible for chloroquine-induced inhibition of cell proliferation: indeed, NOS inhibitors revert the drug-evoked blockage of mitogenesis and ornithine decarboxylase activity in murine and porcine endothelial cells. The NOS-activating effect of chloroquine is dependent on its weak base properties, as it is exerted also by ammonium chloride, another lysosomotropic agent. Both compounds activate NOS by limiting the availability of iron: their stimulating effects on NO synthesis and inhibiting action on cell proliferation are reverted by iron supplementation with ferric nitrilotriacetate, and are mimicked by incubation with desferrioxamine. Our results suggest that NO synthesis can be stimulated in endothelial cells by chloroquine via an impairment of iron metabolism.
Serial Thyroid Iodine Content in Hyperthyroid Patients Treated with Radioiodine
Authors: G S LEE, M P SANDLER, J A PATTON, A B BRILL
Journal: Clinical Nuclear Medicine (1986)

X-ray fluorescent scanning was used to measure initial thyroidal iodine content in 64 patients diagnosed as being hyperthyroid and selected for I-131 therapy, and serially in 48 of these patients after therapy in an attempt to determine those patients that were at high risk of becoming hypothyroid. Iodine content fell rapidly after therapy, reaching a nadir at about three months. Based on the population studied, the chance of early hypothyroidism (within 12 months) is about 80% if the iodine content measured at three months is less than 2 mg. If the iodine content is greater than 2 mg, the chance is only about 14%. The serial measurement of thyroidal iodine content (with x-ray fluorescent scanning) may allow early identification of those patients at high risk of developing permanent hypothyroidism following a therapeutic dose of I-131.
Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of Tropomodulin 3 in red blood cells and disruption of the membrane skeleton
Authors: Jeannette D. Moyer, Roberta B. Nowak, Nancy E. Kim, Sandra K. Larkin, Luanne L. Peters, John Hartwig, Frans A. Kuypers, Velia M. Fowler
Journal: Blood (2010)
Evolution of Membranous Nephropathy into Anti-Glomerular-Basement-Membrane Glomerulonephritis
Authors: John Klassen, Charles Elwood, Allan L. Grossberg, Felix Milgrom, Mario Montes, Marion Sepulveda, Giuseppe A. Andres
Journal: New England Journal of Medicine (1974)

Abstract In a patient with biopsy-proved membranous nephropathy (nephrotic syndrome) acute fatal renal failure suddenly developed. Autopsy revealed rapidly progressive glomerulonephritis superimposed on the previous membranous changes. IgG eluted from the kidney was shown by immunofluorescence technic to bind to the glomerular basement membrane of normal human and monkey kidneys, and was capable of producing an acute anti-glomerular-basement-membrane nephritis in two monkeys. The IgG antibody, by radioisotopic methods, was specifically directed against primate kidney. It is postulated that immune complexes responsible for the original membranous nephropathy induced release of antigenic glomerular-basement-membrane fragments into the circulation, stimulating formation of antibodies to the membrane and producing fatal acute glomerulonephritis. (N Engl J Med 290:1340–1344, 1974)
Nicotine content in smoke from US cigarettes has increased
Authors: Janice Hopkins Tanne
Journal: BMJ (2006)

The amount of nicotine inhaled by cigarette smokers and by bystanders in secondhand smoke has risen by 10% over the past seven years, says a report from the Massachusetts Department of Public Health.

“Although per capita consumption of cigarettes has declined, the amount of nicotine consumed per cigarette has increased. Concurrently, the amount of …
Cardiac ankyrins: Essential components for development and maintenance of excitable membrane domains in heart
Authors: S CUNHA, P MOHLER
Journal: Cardiovascular Research (2006)

Ankyrins are intracellular proteins required for the biogenesis and maintenance of membrane domains in both excitable and non-excitable cells. Ankyrin family polypeptides have been implicated in the targeting and stabilization of membrane proteins including ion channels, transporters, exchangers and cell adhesion molecules in diverse tissues and cell types including the erythrocyte, kidney, lung and brain. Dysfunction in ankyrin-based pathways has previously been linked to abnormalities in vertebrate physiology including spherocytosis and anemia, ataxia and axonal degeneration. Recent findings have illuminated the importance of ankyrin-based pathways in excitable cells of the heart. Specifically, two ankyrin gene products, 220-kDa ankyrin-B and 190-kDa ankyrin-G, have been implicated in the targeting of structurally diverse membrane ion channels and transporters to excitable membrane domains in cardiomyocytes. Moreover, findings in humans and mice have determined the critical nature of ankyrin-based pathways for normal cardiac excitability. Reduction of ankyrin-B expression levels in mice or the presence of ankyrin-B loss-of-function mutations in humans leads to 'ankyrin-B syndrome', a cardiac disease with a spectrum of clinical presentations including bradycardia, ventricular tachycardia and sudden cardiac death in response to catecholaminergic stimuli. Ankyrin-G is required for expression of the major cardiac voltage-gated Na(v) channel, Na(v)1.5, at specialized cardiac membrane domains. Human variants in SCN5A (encodes Na(v)1.5) that block Na(v)1.5 interaction with ankyrin-G lead to loss of Na(v)1.5 membrane expression and Brugada syndrome. Together, these recent findings in heart reinforce the importance of ankyrin-based pathways for normal vertebrate physiology and raise exciting new questions regarding the cellular roles for ankyrin polypeptides in cardiac and other excitable cells. While ankyrins have only been recently identified in heart, our current understanding suggests that elucidating the roles of ankyrins in organizing and targeting protein complexes to excitable membrane domains will yield important insights into the molecular basis of cardiac arrhythmias.
Let's Rethink<i>Roe v. Wade</i>—And Overturn It
Authors: Jack Mulder
Journal: The American Journal of Bioethics (2010)

I agree with Bertha Manninen in her admirably clear argument (2010) that we should rethink Roe v. Wade, though I would have us do so for different reasons. Before beginning, I want to note that I a...
Efficient Gene Transfer to Human Epidermal Keratinocytes on Fibronectin: In Vitro Evidence for Transduction of Epidermal Stem Cells
Authors: Bharat G. Bajaj, Pedro Lei, Stelios T. Andreadis
Journal: Molecular Therapy (2005)

<h2>Abstract</h2> The epidermis is an attractive target for gene therapy because it is easily accessible and has great potential as an ectopic site for protein delivery <i>in vivo</i>. Genetically modified keratinocytes can be expanded in culture and used to generate three-dimensional skin equivalents, which can deliver therapeutic proteins either locally or systemically for the treatment of wounds or systemic diseases. Here we present an optimum protocol that yields consistently high retroviral gene transfer on a substrate of recombinant fibronectin (rFN). Gene transfer on rFN depends strongly on virus concentration and the density of target cells. Interestingly, the kinetics of gene transfer varies depending upon the origin—mouse or human—of virus-producer cells. Most notably, long-term growth and clonogenic assays show that transduction on rFN promotes gene transfer to epidermal stem cells and prevents loss of clonogenic potential due to exposure of cells to retroviral supernatant. In contrast, the traditional protocol transduces mostly differentiated keratinocytes. We also show that skin equivalents prepared from genetically modified keratinocytes display high levels of transgene expression, mainly in the suprabasal layers. Our results are important for cutaneous gene therapy and for biological studies that require efficient and permanent genetic modification.
Earnings of General Practitioners
Authors: D. J. Anderson, G. S. Cruickshank, N. Kitching, R. D. Merson, J. L. Merson, J. A. L. Morrell, J. S. Riddell, A. F. Ritchie, B. Scaife, J. Stohlner, M. Townend
Journal: BMJ (1973)
Vitamin C and risk of death from stroke and coronary heart disease in cohort of elderly people
Authors: C. R Gale, C. N Martyn, P. D Winter, C. Cooper
Journal: BMJ (1995)

<h3>Abstract</h3> <b>Objectives</b>: To determine whether vitamin C status, as measured by dietary intake and plasma ascorbic acid concentration, is related to mortality from stroke and coronary heart disease in people aged 65 and over. <b>Design</b>: A 20 year follow up study of a cohort of randomly selected elderly people living in the community who had taken part in the 1973-4 Department of Health and Social Security nutritional survey and for whom dietary and other data had been recorded. <b>Setting</b>: Eight areas in Britain (five in England, two in Scotland, and one in Wales). <b>Subjects</b>: 730 men and women who had completed a seven day dietary record and who had no history or symptoms of stroke, cerebral arteriosclerosis, or coronary heart disease when examined by a geriatrician in 1973-4. <b>Results</b>: Mortality from stroke was highest in those with the lowest vitamin C status. Those in the highest third of the distribution of vitamin C intake had a relative risk of 0.5 (95% confidence interval 0.3 to 0.8) compared with those in the lowest third, after adjustment for age, sex, and established cardiovascular risk factors. The relation between vitamin C intake and stroke was independent of social class and other dietary variables. A similar gradient in risk was present for plasma ascorbic acid concentrations. No association was found between vitamin C status and risk of death from coronary heart disease. <b>Conclusion</b>: In elderly people vitamin C concentration, whether measured by dietary intake or plasma concentration of ascorbic acid, is strongly related to subsequent risk of death from stroke but not from coronary heart disease. <h3>Key messages</h3> Key messages Vitamin C is the most important dietary antioxidant in terms of intake Both dietary intake of vitamin C and plasma ascorbate concentrations were related to risk of death from stroke (but not from coronary heart disease) in 730 elderly people studied prospectively Vitamin C status was as strong a predictor of death from stroke as diastolic blood pressure Antioxidant vitamins are potentially important in the prevention of cerebrovascular disease
Advantages and Disadvantages of Neonatal Circumcision-Reply
Authors: Edward O. Laumann
Journal: JAMA (1997)

In Reply.  —Collectively, the letters commenting on our article on circumcision are a microcosm of the highly contentious state of opinion on the wisdom of mass neonatal circumcision in the United States. Most of the authors make useful reference to other studies that bear on evaluating the impact of circumcision on such issues as penile sensitivity, sexual satisfaction, and transmission of other diseases to sex partners (eg, cervical cancer) that we could not examine because of the limitations on clinical data gathering imposed by a broad-based population survey such as ours.  However, we take strong exception to Dr Schoen's observation that the survey method is simply inapplicable because of its invalidity for studying STDs. We acknowledged in our article the limitations of self-reported STDs from a lay population, especially with respect to underreporting becaused of selective recall, lack of awareness and of diagnosis of asymptomatic disease, and the avoidance of social stigma.
GW25-e5133 Phosphatase and tensin homologue on chromosome 10 regulates angiotensin II-induced proliferation and collagen metabolism in neonatal rat cardiac fibroblasts through the Akt/P27 signaling pathway
Authors: Ling Nie, Jinghong Zhao, Jiang Wang, Rong Song, Shanjun Zhu
Journal: Journal of the American College of Cardiology (2014)
Fetus Papyraceus With Intrauterine Sibling Death
Authors: Mortimer R. Camiel
Journal: JAMA (1967)

To the Editor:—  When one sibling of a multiple pregnancy dies during early gestation, the dead fetus is retained in utero along with its viable sibling, and it may not interfere with its sibling's growth and survival. An uneventful pregnancy is said to be the rule. 1 An exception is reported in which a fetus papyraceus, or dead twin, was associated with the later intrauterine death of its sibling. The diagnosis was made from antepartum roentgenograms.  Report of a Cas:e:—  The 27-year-old patient was para 0, gravida 1, Rh +, and healthy. Her expected date of delivery was June 24. Her membranes ruptured on April 7. A fetal heart was heard on April 23. Labor began on May 11, but no fetal heart was heard. Roentgenographic study done that day revealed a twin pregnancy one of which was a fetus papyraceus: the other was a recently dead twin, death having taken place between April 23 and May 11. The roentgenographic features are described in the legends accompanying Fig 1 and 2. The next morning there was a spontaneous delivery of dead twins. The first was a macerated fetus papyraceus. Its stillborn twin followed as a breech. There were no complications.
Practical Considerations in Dialysis Withdrawal
Authors: Amy J. Markowitz, Michael W. Rabow
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
REPAIR OF ACQUIRED DEFECTS OF THE FACE
Authors: ROBERT H. IVY
Journal: JAMA (1925)

Plastic surgery of the face has been the object of a great deal of attention during the last few years, chiefly as a result of numerous war injuries of this region. Indeed, among the laity, it is popularly believed that the art is something entirely new, brought out by the world war. It might be of interest to examine the present state of development of this branch of surgery, to survey the efforts of some of the past workers, and to note in what respects progress has been made in recent years. Examination of the literature reveals that from the time of the Italian Tagliacozzi, in the latter half of the sixteenth century, until 1816, when Carpue, in England, published his work on the Indian method of rhinoplasty, reconstructive surgery of the face received very little attention. Rigaud 1 credits Carpue with resurrecting the art, which almost immediately made enormous
A high-density SNP genome-wide linkage search of 206 families identifies susceptibility loci for chronic lymphocytic leukemia
Authors: Gabrielle S. Sellick, Lynn R. Goldin, Ruth W. Wild, Susan L. Slager, Laura Ressenti, Sara S. Strom, Martin J. S. Dyer, Francesca R. Mauro, Gerald E. Marti, Stephen Fuller, Matthew Lyttelton, Thomas J. Kipps, Michael J. Keating, Timothy G. Call, Daniel Catovsky, Neil Caporaso, Richard S. Houlston
Journal: Blood (2007)
Contracts for Hospital Junior Staff
Authors: W. P. Bradford
Journal: BMJ (1973)

BRITISH MEDICAL JOURNAL 24 NOVEMBER 1973 then decide how to make the child as safe as possible, as a first-aid measure, and also try to make provision for the long-term support, supervision, and re-education which the family are going to need.All this is going to be difficult and de- manding for someone, probably several people, and the long-term results may be disappointing.But "prompt referral to the nearest hospital," without thought, is not good enough.-Iam, etc.,
The Future of the Department of Veterans Affairs Health Care System
Authors: Elliott S. Fisher
Journal: JAMA (1995)

PERCEPTIONS vary about the value of the Department of Veterans Affairs (VA) health care system. The VA has recently been described both as "a national asset"<sup>1</sup>and "a second-rate health care system for poor elderly men."<sup>2</sup>But strong opinions should not be the sole determinants of the future of the VA. Size alone demands that this future be given careful consideration. Although the VA's health care budget of $15 billion represents less than 2% of all US health expenditures, it is one of the largest single providers of health care and includes 171 hospitals, 350 outpatient clinics, and 126 nursing homes.<sup>3</sup>In addition, the VA plays a major role in medical education and research. For editorial comment see page 667. Whether others could more effectively play these roles is an important question (<i>Washington Post</i>. March 6, 1993: A4;<i>Wall Street Journal</i>. December 6, 1993:A14). This article reviews
Disseminated herpes simplex after total skin electron beam radiotherapy for mycosis fungoides
Authors: B. D Smith, C. B. Son, L. D Wilson
Journal: Journal of the Royal Society of Medicine (2003)

idiopathic pancreatitis.We have found only three reports 1-3 on pancreatitis associated with a gastric polyp and none with repeated episodes as in the present case.Gastroduodenal intussusception is most commonly due to a benign tumour, 1 and Gardner's syndrome (familial adenomatous polyposis) 2 is one condition in which it has caused pancreatititis. 2 cystic lesion in the vicinity of the pancreas on CT scan, in a patient with a history of acute pancreatitis, is usually interpreted as pseudocyst.In the patient reported here this misinterpretation led to a delay in diagnosis and definitive treatment.
1163-117 Prognostic value of development of atrial fibrillation in outpatients with heart failure: Data from the Italian network on congestive heart failure (IN-CHF registry)
Authors: Gianna Fabbri, Samuele Baldasseroni, Maurizio Marini, Francesca Coppi, Anna Gentile, Lucio Gonzini, Marco Gorini, Franco Ingrilli, Aldo P Maggioni
Journal: Journal of the American College of Cardiology (2004)