tbuckley/cabot-search huggingface dataset:
Elevated Fibrin–Related and Fibrinogen–Related Antigens in Patients With Liver Disease
Authors: Jonathan B. Kruskal, Simon C. Robson, John J. Franks, Ralph E. Kirsch
Journal: Hepatology (1992)

Patients with liver disease have a variety of coagulation abnormalities. These derangements are of uncertain origin and do not always correlate with disease severity or activity. We have measured the levels and proportions of the total fibrin-related and fibrinogen-related antigens, the principal fibrin (D-dimer) and fibrinogen (D-monomer) degradation fragments and intermediates of fibrin formation (fibrin monomers) in patients with a variety of acute and chronic liver diseases in whom all known other precipitating causes of disseminated intravascular coagulation had been excluded. Fibrin-related and fibrinogen-related antigens were extracted from serum using antihuman fibrinogen-IgG covalently bound to activated amino-phenylthioether paper disks and were subjected to 4% to 11% sodium dodecyl sulfate-polyacrylamide gel electrophoresis under nonreducing conditions. Fibrin-related and fibrinogen-related antigen proportions were determined by densitometry, and their levels were measured by radioimmunoassay. Levels of total fibrin-related and fibrinogen-related antigens (and D-dimer) were significantly elevated (p less than 0.01) in patients with cirrhosis (121 to 641 ng/ml) and hepatocellular carcinoma (416 to 8,786 ng/ml) when compared with patients with acute viral hepatitis (84 to 322 ng/ml) and control subjects (38 to 186 ng/ml). In addition, D-monomer levels were elevated. These findings strongly suggest that disseminated intravascular coagulation is a component of the coagulopathy of certain liver diseases. Because fibrin-related and fibrinogen-related antigens have anticoagulant, vasoactive and immunosuppressive properties, their elevated presence may be biologically significant in these patients.
Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: a molecular study
Authors: B. Heym, N. Honoré, C. Schurra, S.T. Cole, B. Heym, C. Truffot-Pernot, J.H. Grosset, A. Banerjee, W.R. Jacobs, J.D.A. van Embden
Journal: The Lancet (1994)
Inhibition of tumor angiogenesis mediated by cartilage.
Authors: H Brem, J Folkman
Journal: The Journal of Experimental Medicine (1975)

Capillary proliferation induced by tumor is shown to be inhibited by neonatal scapular cartilage. Using the rabbit cornea as an assay, the cartilage implant decreased the rate of capillary growth, induced by tumor, by an average of 75%. Vascularization was prevented completely in 28% of tumors. The inhibitory effect of small cartilage implants operates over distances of up to 2.0 mm and displays a gradient from the cartilage source. The experiments suggest that the cartilage inhibitor does not antagonize tumor angiogenesis factor, but appears to inhibit capillary proliferation directly. The inhibitory material does not elicit an inflammatory response in either the rabbit cornea or in the chick chorioallantoic membrane. Thus with further purification, it may prove useful as a means of maintining tumor dormancy by "antiangiogenesis."
Nonischemic Chest Pain Induced by Coronary Interventions
Authors: Allen Jeremias, Sven Kutscher, Michael Haude, Dagmar Heinen, Gerald Holtmann, Wolfgang Senf, Raimund Erbel
Journal: Circulation (1998)

Background —Chest pain frequently occurs without any signs of ischemia within the first 24 hours after coronary interventions. To test the hypothesis that this pain may be due to local vessel injury (“stretch pain”), we performed a prospective study enrolling patients after PTCA, stent implantation, or diagnostic coronary angiography alone. Methods and Results —A total of 145 patients after coronary angiography were evaluated by a validated questionnaire for quantifying postinterventional chest pain within 24 hours. To detect myocardial ischemia, all patients were evaluated with a 12-lead ECG and cardiac isoenzymes immediately after the procedure and the morning after. After stent implantation, 21 of the 51 patients (41.2%) developed chest pain, compared with 4 of the 33 patients (12.1%) undergoing PTCA and 6 of the 61 patients (9.8%) with a diagnostic angiography ( P &lt;0.001). Of these 31 patients who developed chest pain, only 3 (9.7%) felt that the pain was similar to previously experienced angina pectoris. The minimal lumen diameter after intervention was significantly larger in the stent group than in the PTCA group (3.14±0.75 versus 1.95±0.67 mm; P &lt;0.001). No patient had changes in the ECG compared with before intervention, but 3 patients after stent implantation had a rise in cardiac isoenzymes. No other major adverse cardiac events occurred until discharge. Conclusions —Nonischemic chest pain develops in almost half of all patients undergoing stent implantation and seems to be related to vessel overexpansion caused by the stent in the diseased vessel segment.
European governments should sue Roche and prescribers should boycott its drugs
Authors: P. C. Gotzsche
Journal: BMJ (2012)

At an open seminar arranged by Health Action International (Europe) on 12 October 2012 about access to medical research data, I asked why European governments had not sued Roche to get the money back that they had spent on needlessly stockpiling oseltamivir (Tamiflu). Roche has withheld data that purport to show that oseltamivir has dramatic effects. We all wonder why it …
SURGICAL CLINIC, AT THE HARLEM HOSPITAL, NEW YORK.
Authors: THOMAS H. MANLEY
Journal: JAMA (1892)

[Reported exclusively for The Journal of the American Medicai. Association.] <i>Gentlemen:</i>—You will remember, in the notice of this clinic, it was announced that among other operations which we would proceed with to-day, was one of abdominal section, for the removal of an interstitial fibroid of the womb; an abdominal hysterectomy, so-called. Well, hereis the patient before you; and, while we must congratulate her on her escape from the perilous ordeal which was before her, we are sorry to have disappointed you. But, it seems to me, that the history of this case and the simple means by which she has been rapidly and radically relieved of her infirmity, are by far of more practical value than would be any operation, which would involve the loss of blood and an extensive mutilation. Her history is briefly this: she is 43 years old, free from any organic disease, and had good general
Osteoporosis and Mortality
Authors: Lawrence G. Raisz
Journal: Annals of Internal Medicine (1997)

Letters1 December 1997Osteoporosis and MortalityLawrence G. Raisz, MDLawrence G. Raisz, MDUniversity of Connecticut Health Center; Farmington, CT 06030-1850Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-11-199712010-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I would like to thank Dr. Galus for bringing up the important issue of increased mortality in patients with osteoporotic fractures. In an epidemiologic study based on the geographically defined population of Rochester, Minnesota, Cooper and associates [1] found a significant reduction in relative 5-year survival of about 20% in patients with hip and vertebral fracture but not patients with Colles fracture of the distal forearm. The patients with vertebral fracture showed a progressive increase in excess mortality over 5 years, whereas the excess mortality in patients with hip fracture occurred largely in the first 6 months after ...References1. Cooper C, Atkinson EJ, Jacobsen SJ, O'Fallon WM, Melton LJ III. Population-based study of survival after osteoporotic fractures. Am J Epidemiol. 1993; 137:1001. Google Scholar2. Browner WS, Pressman AR, Nevitt MC, Cummings SR. Mortality following fractures in older women. The study of osteoporotic fractures. Arch Intern Med. 1996; 156:1521-5. Google Scholar3. Poor G, Atkinson EJ, O'Fallon WM, Melton LJ III. Determinants of reduced survival following hip fractures in men. Clin Orthop Rel Res. 1995; 319:260-5. Google Scholar4. Browner WS, Pressman AR, Nevitt MC, Cauley JA, Cummings SR. Association between low bone density and stroke in elderly women. The study of osteoporotic fractures. Stroke. 1993; 24:940-6. Google Scholar5. Cauley JA, Lucas FL, Kuller LH, Vogt MT, Browner WS, Cummings SR. Bone mineral density and risk of breast cancer in older women-the study of osteoporotic fractures. JAMA. 1996; 276:1404-8. Google Scholar Author, Article, and Disclosure InformationAuthors: Lawrence G. Raisz, MDAffiliations: University of Connecticut Health Center; Farmington, CT 06030-1850 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1997Volume 127, Issue 11Page: 1040KeywordsBone densityBreast cancerEpidemiologyHipHip fracturesMorbidityMortalityOsteoporosisStrokeSurgery ePublished: 15 August 2000 Issue Published: 1 December 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Interferon and hepatocellular carcinoma
Authors: RonaldL. Koretz, Tetsuo Kuroki, Shuhei Nishiguchi, Shinji Nakatani, Pietro Andreone, Carmela Cursaro, Annagiulia Gramenzi, Franco Trevisani, Giovanni Gasbarrini, Mauro Bernardi
Journal: The Lancet (1996)
Abstract LB-85: Ectopic expression of eukaryotic translation elongation factor eEF1A2 is a hallmark for human lung cancer and is associated with poor prognosis
Authors: Xiao-Yun Liu, Wei Zhang, Luc Girard, Boning Gao, Jill Larsen, Ignacio Ivan Wistuba, Eugene Frenkel, Jason Toombs, Rolf Brekken, John Minna, Adi Gazdar
Journal: Cancer Research (2012)

Abstract Background: The elongation factor eEF1A is one of the most abundantly expressed cellular proteins. It exists in two forms, eEF1A2, expressed in neurons and striated muscle, and eEF1A1, expressed in all other cell types. No normal adult cell expresses both forms. We investigated their role in lung cancer. Methods: We studied over 500 NSCLC and SCLC lung cancers and over 170 cell lines, as well as corresponding non- malignant lung tissues and immortalized respiratory epithelial lines. Methods included microarray, qPCR, immunostaining and western blots for eEF1A1 and eEF1A2, genomic sequencing and SNP analyses. Results: All normal and malignant cells highly expressed eEF1A1. EEF1A2 was expressed in 70-80% of all forms of lung cancers and 95% of cell lines, while all non-malignant tissues were negative. Expression of eEF1A2 in neuroendocrine tumors was particular high. The ectopic expression of eEF1A2 was not the consequence of mutations or copy number gains. Use of demethylating agents and HDAC inhibitors resulted in expression of eEF1A2 in respiratory epithelial cells, indicating that epigenetic mechanisms prevented expression in non-malignant cells. Transient knockdown of the eEF1A2 expression inhibited proliferation and colony formation of lung cancer cell lines. Furthermore, the expression of eEF1A2 in resected NSCLC cancers was associated with poor survival. Conclusions: Highly specific ectopic expression of eEF1A2 gene is frequent in all types of lung cancer, plays an important role in tumor pathogenesis and is a potential diagnostic and prognostic factor. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-85. doi:1538-7445.AM2012-LB-85
Quantitative real-time myocardial contrast echocardiography for detection of coronary artery disease: comparison with MIBI SPECT and coronary angiography
Authors: Marcel Peltier, Agnés Pasquet, Anne-Marie d'Hondt, David Vancraeynest, Taniyel Ay, Jacques Melin, Jean-Louis Vanoverschelde
Journal: Journal of the American College of Cardiology (2002)
X-ray Viewing Box in Your Living Room
Authors: Jacob J. Silverman
Journal: JAMA (1970)

To the Editor.—  May I call your attention to a substitute x-ray film viewing box in the form of an ordinary television set? By placing an x-ray film in front of the television screen and adjusting a channel selector not quite fully locked, a bright fluorescent light is projected through the film when the power is turned on. Intensity of the light may be further enhanced by adjusting the dial controlling brightness. The only contraindication is when little Johnny is watching his favorite program.
Postirradiation pulmonary fibrosis complicated by aspergilloma and bronchocentric granulomatosis.
Authors: H Makker, K McConnochie, A R Gibbs
Journal: Thorax (1989)

An asthmatic patient requiring corticosteroid treatment developed a pulmonary aspergilloma in an area of postmastectomy radiation fibrosis. At necropsy bronchocentric granulomatosis was also found.
UK proposes new approach to personality disorders
Authors: C. Dyer
Journal: BMJ (1999)

Proposals for new powers to lock up dangerous people with severe personality disorders who have committed no offence were outlined by the British government this week.

Ministers are considering two options in England and Wales: strengthening current powers to detain people who pose a risk in either prison or hospital, or creating a new specialist service to house those with severe antisocial personality disorders. Although those who commit serious crimes can be detained under the current law, civil detention or “sectioning” under the Mental …
Drug Treatment of the Rheumatic Diseases
Authors: R Melsom
Journal: Annals of the Rheumatic Diseases (1988)

Published two years after the death of Edmund Dubois, this volume on systemic lupus erythematosus (SLE) is a tribute to his understanding of this challenging disease.Dubois' insight and far reaching perspective are much in evidence despite the book's multiple authors.When one looks at successive editions his stamp on the language of the book is also obvious.Although it is distinctly North American, it is often somewhat archaic even in discussing recent developments.The book is as up to date as any reference work can be in such a rapidly developing field, and yet one senses a reluctant transition from the era of the
INDUCED LEUCOCYTOSIS IN THE TREATMENT OF INFECTIONS
Authors: W. A. Elliott
Journal: BMJ (1925)

SOME twelve months ago Dr. Burr Fergusoni of the U-nited States Public Health Service, Southampton, spoke to me of the results he had obtained by injections of mercurv salicylate in the treatment of infective conditions, and I decided to try it in some suitable cases.The method consists in the intramuscular injection of a mixture of mercur-y salicylate in liquid paraffin (1 grain per cubic centimetre), 1 c.cm. being injected at intervals of one week up to four or six doses, or less if the desired result is obtained earlier.This is the usual method, of course, in treating syphilis.Some of the cases which I tried were as follows: CASE I.
DIFFERENT TIME COURSE OF NEOATHEROSCLEROSIS DEVELOPMENT IN BARE METAL STENTS, SIROLIMUS–ELUTING STENTS AND PACLITAXEL–ELUTING STENTS
Authors: Hirotoshi Hariki, Toshiro Shinke, Hiromasa Otake, Masayuki Nakagawa, Takumi Inoue, Tsuyoshi Osue, Yu Taniguchi, Masamichi Iwasaki, Ryo Nishio, Hiranuma Noritoshi, Hiroto Kinutani, Akihide Konishi, Ken–ichi Hirata
Journal: Journal of the American College of Cardiology (2013)
Queries and Minor Notes
Authors: I. H. Goldberger
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Newborn Screening
Authors: Donald B. Bailey, Lisa Gehtland
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones.
Authors: E Meinl, F Weber, K Drexler, C Morelle, M Ott, G Saruhan-Direskeneli, N Goebels, B Ertl, G Jechart, G Giegerich
Journal: Journal of Clinical Investigation (1993)

The human T cell response to the myelin basic protein (MBP) has been studied with respect to T cell receptor (TCR) usage, HLA class II restriction elements, and epitope specificity using a total of 215 long-term MBP-specific T cell lines (TCL) isolated from the peripheral blood of 13 patients with multiple sclerosis (MS) and 10 healthy donors. In most donors, the anti-MBP response was exceedingly heterogeneous. Using a panel of overlapping synthetic peptides spanning the entire length of human MBP, at least 26 epitopes recognized by human TCL could be distinguished. The MBP domain most commonly recognized was sequence 80-105 (31% of MS TCL, and 24% of control TCL). Sequence 29-48 was recognized more frequently by control-derived TCL (24%) than by TCL from MS patients (5%). The MBP epitopes were recognized in the context of DRB1 *0101, DRB5*0101, DRB1*1501, DRB1*0301, DRB1*0401, DRB1*1402, and DRB3*0102, as demonstrated using a panel of DR gene-transfected L cells. The TCR gene usage was also heterogeneous. V beta 5.2, a peptide of which is currently being used in a clinical trial for treatment of MS patients, was expressed by only one of our TCL. However, within this complex pattern of MBP-specific T cell responses, a minority of MS patients were found to exhibit a more restricted response with respect to their TCL epitope specificity. In these patients 75-87% of the TCL responded to a single, patient-specific cluster of immunodominant T cell epitopes located within a small (20-amino acid) domain of MBP. These nested clusters of immunodominant epitopes were noted within the amino acids 80-105, 108-131, and 131-153. The T cell response to the immunodominant epitopes was not monoclonal, but heterogeneous, with respect to fine specificity, TCR usage, and even HLA restriction. In one patient (H.K.), this restricted epitope profile remained stable for > 2 yr. The TCR beta chain sequences of TCL specific for the immunodominant region of HK are consistent with an oligoclonal response against the epitopes of this region (80-105). Further, two pairs of identical sequences were established from TCL generated from this patient at different times (June 1990 and June 1991), suggesting that some TCL specific for the immunodominant region persisted in the peripheral repertoire. The possible role of persistent immunodominant epitope clusters in the pathogenesis of MS remains to be established.
Hackney GPs plan to take control of out of hours care from April
Authors: Z. Kmietowicz
Journal: BMJ (2013)

GPs in the London borough of Hackney are setting up a social enterprise to try to take back the running of urgent and out of hours care for their patients from the private company Harmoni.

Hackney Urgent Healthcare Social Enterprise is due to launch on 2 April, when GPs nationally take responsibility for commissioning most patients’ services through clinical commissioning consortiums, as part of the changes introduced by last year’s Health and Social Care Act.

In an announcement to patients about the planned changes for urgent and out of out of hours care in Hackney, the Lawson Practice, part of …
Was Risk of Suicide Underestimated?
Authors: Merete Nordentoft, Thomas Munk Laursen
Journal: JAMA Psychiatry (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Adverse Outcomes of Underuse of β-Blockers in Elderly Patients
Authors: Daniel Levinson
Journal: JAMA (1997)

<h3>To the Editor.</h3> —The Editorial by Drs Felch and Scanlon<sup>1</sup>summarizing the status of continuing medical education (CME) enumerates all the conventional approaches to CME and suggests that the correct answer is all of the above. But, as the authors acknowledge, educational techniques involving self-study, occasional courses, seminars, and consultations have never been more than an approximate answer to the problems of comprehensive coverage of one's area of practice or of accurate recall of specific information when a clinical challenge arises. Indeed, given the complexity of the practice of even a limited specialty, it is ludicrous to think that anyone can acquire or retain by occasional study more than a fraction of the information necessary for optimal care of each patient in a physician's practice. Add the fact that clinicians vary widely in their CME effort and the result is a situation in which substantial numbers of patients are denied access to