tbuckley/cabot-search huggingface dataset:
Jeryl Lynn Strain Live Attenuated Mumps Virus Vaccine
Authors: Robert E. Weibel
Journal: JAMA (1968)

There was no substantial decline in mumps neutralizing antibody up to two years following Jeryl Lynn strain vaccine compared with the titer one month after vaccination. The pattern of antibody persistence closely approximated that observed following natural mumps. Initially seronegative children who received the vaccine 8 to 20 months previously were followed up for immunity to natural mumps challenge during a second mumps season. Fifty-three cases of mumps occurred among 78 initially susceptible controls in contrast to two cases among 53 initially susceptible vaccinees, giving a protective efficacy of 94%. The two vaccine failures were in children who did not respond serologically to the vaccine. The pattern of antibody persistence suggests that immunity following vaccination will be lasting.
Prevalence of Huntington's disease is underestimated in UK
Authors: J. Wise
Journal: BMJ (2010)

The prevalence of Huntington’s disease in the UK has been massively underestimated and is more than double the current estimates, doctors have claimed.

UK studies carried out in the 1970s and 80s show an average prevalence of 6-7 cases per 100 000 of the population. But writing in the Lancet this week, Professor Sir Michael Rawlins, honorary professor of the London School of Hygiene and Tropical Medicine and chairman of the National Institute for Health and Clinical Excellence, states: “The true prevalence of Huntington’s disease is unquestionably greater than that rate.” ( Lancet DOI:10.1016/S0140-6736(10)60974-9.)

The Huntington’s Disease Association, a not for profit organisation …
Functional Tetrahydrobiopterin Synthesis in Human Platelets
Authors: Nicola Franscini, Esther B. Bachli, Nenad Blau, Manuel Fischler, Roland B. Walter, Andreas Schaffner, Gabriele Schoedon
Journal: Circulation (2004)

Background— Previous studies have provided evidence for the importance of platelet-derived nitric oxide (NO) for the regulation of hemostasis. Tetrahydrobiopterin (BH 4 ) is an essential cofactor and regulator of NO synthase activity in the vasculature; however, it is as yet unknown whether platelets dispose over a functional BH 4 synthesis. Methods and Results— We quantified mRNA expression of genes involved in BH 4 synthesis, measured enzymatic activities, and determined intraplatelet levels of pteridines in platelets from healthy volunteers and from patients treated for prolonged periods of time with glucocorticoids. Freshly isolated platelets from healthy volunteers show functional BH 4 synthesis, as evidenced by the presence of mRNA species and enzymatic activity of GTP cyclohydrolase I (GTPCH), 6-pyruvoyl tetrahydropterin synthase, and sepiapterin reductase. Biopterin was the major intraplatelet pteridine, whereas no neopterin was found. mRNA expression and enzymatic activity of GTPCH were undetectably low in platelets that had been stored for 5 days, and no pteridines were found in these platelets. Freshly isolated platelets from patients treated with glucocorticoids had decreased mRNA expression and activity of GTPCH compared with platelets from healthy volunteers. Conclusions— Human platelets dispose over a functional de novo BH 4 synthesis. Furthermore, our results indicate the potential of external factors, eg, prolonged storage or glucocorticoid therapy, to significantly affect BH 4 synthesis within platelets. Together, these findings offer new insights into the biology and pathobiology of platelet function in humans.
Book Review Ethics and the Pharmaceutical Industry Edited by Michael A. Santoro and Thomas M. Gorrie. 492 pp. New York, Cambridge University Press, 2005. $40. 0-521-85496-2 The Law and Ethics of the Pharmaceutical Industry By M.N. Graham Dukes. 409 pp. Amsterdam, Elsevier, 2006. $129.95. 0-444-51868-1
Authors: Jeremy Sugarman
Journal: New England Journal of Medicine (2006)
Differential structure-function requirements of the transmembranal domain of the B cell antigen receptor.
Authors: V S Parikh, G A Bishop, K J Liu, B T Do, M R Ghosh, B S Kim, P W Tucker
Journal: The Journal of Experimental Medicine (1992)

By generating phosphorylcholine (PC)-specific, wild-type (mu), and chimeric (mu-I-A alpha) antigen receptor transfectants of mature B cells, we have shown that the COOH terminus of the mu heavy chain is essential for three major functions: immediate signal transduction (measured as changes in intracellular Ca2+), antigen presentation, and induction of immunoglobulin M secretion. A more detailed analysis of structural requirements of the COOH-terminal domains contributing to these functions was achieved by systematically replacing the spacer, cytoplasmic, and transmembranal domains of the mu-I-A alpha chimeric chain with those of mu. Using this rescue approach, we show that the carboxyl two-thirds of the transmembranal domain (proximal to the cytoplasmic domain) is required for induction of intracellular Ca2+, whereas the complete transmembranal domain is required for the function of antigen presentation but is dispensable for induction of antibody secretion.
Bioethics in Washington: Yes, but How?
Authors: Frank Miller
Journal: JAMA (1994)

<h3>To the Editor.</h3> —Bioethics has not had a permanent presence in Washington for more than a decade. This August, the Office of Science and Technology Policy (OSTP) called for the creation, by executive order, of a National Bioethics Advisory Commission in response to congressional interest and a report by the Office of Technology Assessment. The OSTP proposes that a standing advisory body be created within the executive branch to consider issues arising from "research on human biology and behavior and the applications of that research." The commission would offer advice and recommendations to the public about government programs, policies, and regulations related to research in human biology and behavior. It would also identify broad principles that should govern the ethical conduct of research. Among the kinds of issues the OSTP envisions the commission examining are the management and use of genetic information and the clarification of the concept of "minimal
Retinopathy at Diagnosis of Diabetes, with Special Reference to Patients under 40 Years of Age
Authors: N. G. Soler, M. G. Fitzgerald, J. M. Malins, R. O. C. Summers
Journal: BMJ (1969)

Diabetic retinopathy was present in 7.5% of 5,157 newly diagnosed patients seen at the Birmingham General Hospital Diabetic Clinic between 1960 and 1967. Although die condition becomes commoner with increasing age it is found in 1.5% of patients aged 20 to 39 years. The aetiology is discussed, the conclusion being that in young as in elderly diabetics asymptomatic diabetes of long duration is the main factor.
The L type calcium current in single hypertrophied cardiomyocytes isolated from the right ventricle of ferret heart
Authors: A. Bouron, D. Potreau, G. Raymond
Journal: Cardiovascular Research (1992)

Journal Article The L type calcium current in single hypertrophied cardiomyocytes isolated from the right ventricle of ferret heart Get access Alexandre Bouron, Alexandre Bouron Laboratory of General Physiology, URA CNRS No 290, University of Poitiers, 40 avenue Recteur Pineau, F-86022 Poitiers cedex, France Correspondence to Dr Potreau. Search for other works by this author on: Oxford Academic PubMed Google Scholar Daniel Potreau, Daniel Potreau Laboratory of General Physiology, URA CNRS No 290, University of Poitiers, 40 avenue Recteur Pineau, F-86022 Poitiers cedex, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Guy Raymond Guy Raymond Laboratory of General Physiology, URA CNRS No 290, University of Poitiers, 40 avenue Recteur Pineau, F-86022 Poitiers cedex, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 7, July 1992, Pages 662–670, https://doi.org/10.1093/cvr/26.7.662 Published: 01 July 1992 Article history Received: 23 July 1991 Accepted: 23 January 1992 Published: 01 July 1992
REPORT FROM INDIANA.
Authors: GEORGE SUTTON
Journal: JAMA (1885)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
US body reviews errors in emergency departments
Authors: R. Dobson
Journal: BMJ (2003)

About 2000 medication errors in hospital emergency departments are reported annually in the United States, a new report says.

The US Pharmacopeia, an independent non-governmental organisation that monitors drug safety, has now made a series of recommendations aimed at lowering the number of errors. The organisation had analysed data on medication errors held on its national databases, which contain more than 360000 reports of such errors since 1998. In 2001, …
In Love With Daylight: A Memoir of Recovery
Authors: Donald W. Goodwin
Journal: JAMA (1995)

This is a lovely book. The world's most boring piece of advice—"You must read this"—becomes irresistible. Of course, people<i>mustn't</i>do anything. Properly,<i>must</i>readers should be reduced to doctors (all doctors), people with alcohol and pill problems, and people who deal with these people. Tens of millions at most. The author went through the alcohol and pill problem and, after two years of almost unbearable suffering, recovered. He had led the jolly drinking life of New York writer/editor for 35 years, then started mixing benzodiazepines and booze, and his life, like a gravitationally collapsing star, disappeared from the universe: a black hole. Many people would have predicted that he would be dead in a short time—very likely by suicide. (At one point, if he had had a gun, they probably would have been right.) When he finally recovered (and what a recovery!), he decided that drinking was fun but
Lactoferrin-modified PEG-co-PCL nanoparticles for enhanced brain delivery of NAP peptide following intranasal administration
Authors: Zhongyang Liu, Mengyin Jiang, Ting Kang, Deyu Miao, Guangzhi Gu, Qingxiang Song, Lei Yao, Quanyin Hu, Yifan Tu, Zhiqing Pang, Hongzhuan Chen, Xinguo Jiang, Xiaoling Gao, Jun Chen
Journal: Biomaterials (2013)
Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 Gene Fusions in Prostate Cancer
Authors: Beth E. Helgeson, Scott A. Tomlins, Nameeta Shah, Bharathi Laxman, Qi Cao, John R. Prensner, Xuhong Cao, Nirmish Singla, James E. Montie, Sooryanarayana Varambally, Rohit Mehra, Arul M. Chinnaiyan
Journal: Cancer Research (2008)

Abstract Recurrent gene fusions involving oncogenic ETS transcription factors (including ERG, ETV1, and ETV4) have been identified in a large fraction of prostate cancers. The most common fusions contain the 5′ untranslated region of TMPRSS2 fused to ERG. Recently, we identified additional 5′ partners in ETV1 fusions, including TMPRSS2, SLC45A3, HERV-K_22q11.23, C15ORF21, and HNRPA2B1. Here, we identify ETV5 as the fourth ETS family member involved in recurrent gene rearrangements in prostate cancer. Characterization of two cases with ETV5 outlier expression by RNA ligase–mediated rapid amplification of cDNA ends identified one case with a TMPRSS2:ETV5 fusion and one case with a SLC45A3:ETV5 fusion. We confirmed the presence of these fusions by quantitative PCR and fluorescence in situ hybridization. In vitro recapitulation of ETV5 overexpression induced invasion in RWPE cells, a benign immortalized prostatic epithelial cell line. Expression profiling and an integrative molecular concepts analysis of RWPE-ETV5 cells also revealed the induction of an invasive transcriptional program, consistent with ERG and ETV1 overexpression in RWPE cells, emphasizing the functional redundancy of ETS rearrangements. Together, our results suggest that the family of 5′ partners previously identified in ETV1 gene fusions can fuse with other ETS family members, suggesting numerous rare gene fusion permutations in prostate cancer. [Cancer Res 2008;68(1):73–80]
[642] THE EXPRESSION OF LIVER PROGENITOR CELLS -PREDICTIVE FACTOR OF ANTIVIRAL THERAPY RESPONSE IN PATIENTS WITH GENOTYPE 1 VIRAL C CHRONIC HEPATITIS
Authors: I. Rogoveanu, D.L. Sandulescu, T. Ciurea, D.I. Gheonea, V. Comanescu, P. Badea
Journal: Journal of Hepatology (2007)
Treatment of Ejaculatio Praecox with Thioridazine
Authors: Arne Mellgren
Journal: Psychotherapy and Psychosomatics (1967)

Research Articles| February 12 2010 Treatment of Ejaculatio Praecox with Thioridazine Subject Area: Psychiatry and Psychology Arne Mellgren Arne Mellgren Psychosomatic Department, Allmänna Barnbördshuset, Stockholm Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1967) 15 (6): 454–460. https://doi.org/10.1159/000285909 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Arne Mellgren; Treatment of Ejaculatio Praecox with Thioridazine. Psychother Psychosom 1 June 1967; 15 (6): 454–460. https://doi.org/10.1159/000285909 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1967Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
A new pimarane-type diterpenoid from moss Pseudoleskeella papillosa (Lindb.) Kindb
Authors: Na Liu, Song Wang, Hongxiang Lou
Journal: Acta Pharmaceutica Sinica B (2012)

A new pimarane-type diterpenoid, momilactone C (1), together with one known compound, momilactone A (2), was isolated from moss Pseudoleskeella papillosa by column chromatography on silica gel, Sephadex LH-20 and semi-preparative HPLC. Their structures were established on the basis of HR–ESI–MS, 1D and 2D NMR spectroscopic methods. Allelopathic test showed that the two diterpenoids inhibited germination of the Arabidopsis thaliana seeds.
PATHOLOGIC CONDITIONS OF THE PHARYNX AND CONTIGUOUS STRUCTURES DURING EARLY CHILDHOOD, PRIME FACTORS IN THE ETIOLOGY OF MALFORMED MAXILLÆ AND IRREGULAR TEETH, ETC.
Authors: WILLIAM A. MILLS
Journal: JAMA (1898)

The physiologic functions of the nasal cavities are as follows: "They elevate the temperature of the inhaled air, give it moisture, and purify it by arresting all particles of dust and other substances which it may contain;" they act as resonance cavities for the voice and are also the seat of the sense of smell. A professional experience of more than twenty-five years, has taught me that any inflammatory lesions-found in children between the ages of 4 and 12 years-which obstruct these natural conditions, are in the majority of cases, the chief agents in the causation of malformed jaws, and the consequent abnormal alignment of the teeth. (To the same cause can be attributed beaked or hooked noses, so often found in connection with these deformities.) I have reached this conclusion after many years of ceaseless endeavor to trace out cause and effect. Others may theorize differently, but theory alone
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
Authors: Laura E. Benjamin, Dragan Golijanin, Ahuva Itin, Dov Pode, Eli Keshet
Journal: Journal of Clinical Investigation (1999)

Features that distinguish tumor vasculatures from normal blood vessels are sought to enable the destruction of preformed tumor vessels. We show that blood vessels in both a xenografted tumor and primary human tumors contain a sizable fraction of immature blood vessels that have not yet recruited periendothelial cells. These immature vessels are selectively obliterated as a consequence of vascular endothelial growth factor (VEGF) withdrawal. In a xenografted glioma, the selective vulnerability of immature vessels to VEGF loss was demonstrated by downregulating VEGF transgene expression using a tetracycline-regulated expression system. In human prostate cancer, the constitutive production of VEGF by the glandular epithelium was suppressed as a consequence of androgen-ablation therapy. VEGF loss led, in turn, to selective apoptosis of endothelial cells in vessels devoid of periendothelial cells. These results suggest that the unique dependence on VEGF of blood vessels lacking periendothelial cells can be exploited to reduce an existing tumor vasculature.
Patterns of Drug Use Among College Students: A Preliminary Report
Authors: GEORGE L. MIZNER, JAMES T. BARTER, PAUL H. WERME
Journal: American Journal of Psychiatry (1970)

In a large survey of college student drug use in the Denver-Boulder metropolitan area, almost one-third of students admitted to having used illegal drugs. The most commonly used illegal drug was marijuana, which had been used by 26 percent of the students. Amphetamines had been used by 14 percent and LSD by five percent. The authors explore attitudes toward drug use and drug legislation as well as mood states and reasons for drug use. Patterns of drug use are contrasted with a variety of demographic variables and with different college and university characteristics.
German medical academics are accused of helping students obtain doctorates for cash
Authors: N. Stafford
Journal: BMJ (2009)

Medical academics are among about 100 professors in Germany who are being investigated for accepting cash bribes to help students obtain doctoral degrees.

Gunther Feld, the senior prosecutor in Cologne who is leading the investigation, declined to reveal the number of medical school professors involved or to name their medical schools. But he confirmed that “several” medical school professors were being investigated and could face criminal prosecution. Medical doctors were also among those who may have illegally obtained doctoral degrees, he told the BMJ .

Supervision of dissertations for doctoral degrees in …
Eccrine poroma: another cause of a pigmented scalp nodule
Authors: H. Kakinuma, M. Kobayashi
Journal: British Journal of Dermatology (2002)

Many types of non‐melanocytic tumour‐forming skin neoplasms (melanoacanthoma, seborrhoeic keratosis, eccrine poroma, Bowenoid papulosis, nodular hidradenoma, basal cell carcinoma and squamous cell carcinoma) occasionally or frequently show pigmentation, and should be differentiated from malignant melanoma (Fig. 1). Such pigmentation is observed even in the plaque‐forming skin neoplasmas (solar keratosis, Bowen's disease, mammary and extramammary Paget's disease), and these neoplasms occasionally show depigmentation or a mixture of both. These pigmentary changes are caused by the quantitative differences of the melanin transfer disorder, melanocyte proliferation and destruction and number of melanophage (Fig. 2) .
Abstract 1244: The requirement of autophagy pathway for drug-induced senescence in human melanoma cells by AZD1152
Authors: Gao Zhang, Meenhard Herlyn
Journal: Cancer Research (2011)

Abstract Oncogene-induced senescence (OIS) is a well-documented phenomenon both in vitro and in vivo as a tumor-suppression mechanism. It functions as a barrier to tumor initiation and progression. However, tumor cells quickly develop a sophisticated yet not well-understood mechanism to overcome and subsequently repress cellular senescence to facilitate its progression. Here we have focused on the drug-induced senescence in human melanoma cells by inhibition of Aurora B kinase (AURKB) through either small molecule AZD1152 or shAURKB. By implementing a systems biology approach, we have uncovered the necessity of mTOR, and autophagy/lysosome pathways for the drug-induced senescence in human melanoma cells. Particularly, the mTOR inhibitor Rapamycin suppresses the senescence phenotype by converting senescence to quiescence, whereas the autophagy inhibitor Bafilomycin A1 or Hydroxychloroquine can induce cell death in senescent melanoma cells induced by AZD1152, suggesting that autophagy is an important survival mechanism for senescent melanoma cells. Thus our study can potentially lead to a framework of utilizing the pro-senescence therapy followed by inhibition of autophagy as a novel clinic approach toward melanoma prevention and cure. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1244. doi:10.1158/1538-7445.AM2011-1244