Hemolysis and Pancytopenia in Ethchlorvynol Overdose
Authors: JOHN C. KLOCK
Journal: Annals of Internal Medicine (1974)

Comments1 July 1974Hemolysis and Pancytopenia in Ethchlorvynol OverdoseJOHN C. KLOCK, M.D.JOHN C. KLOCK, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-1-131_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Ethchlorvinol (Placidyl®, Abbott Laboratories, North Chicago, Illinois) has been known to cause serious central nervous system depression and cardiovascular collapse if taken in large amounts (1-4). Its spectrum of hematologic toxicity is not known aside from a case of immune thrombocytopenia (5).A previously healthy 29-year-old physician ingested between 200 and 250 500-mg Placidyl capsules in a suicide attempt (13 July 1973). He was hospitalized within 40 minutes of ingestion. Examination showed a lethargic man (75 kg) with a blood pressure of 100/80 mm Hg; pulse, 50/min; respiration, 10/min; and temperature, 35.6 °C. Gastric lavage produced many...References1. TEEHAN B, MAHER J, and CAREY J: Acute ethchlorvynol (Placidyl®) intoxication. Ann Intern Med 72:785-882, 1970 LinkGoogle Scholar2. ROBBINS R and APPELROUTH D: Acute ethchlorvynol (Placidyl®) intoxication (letter). Ann Intern Med 73:857-858, 1970 LinkGoogle Scholar3. WESTERVELT F: Ethchlorvynol (Placidyl®) intoxication. Experience with five patients, including treatment with hemodialysis. Ann Intern Med 64:1229-1236, 1966 LinkGoogle Scholar4. ALGERI E, KOTSAS G, and LUONGO M: Determination of ethchlorvynol in biologic mediums and report o ftwo fatal cases. Am J Clin Pathol 38:125-130, 1962 CrossrefMedlineGoogle Scholar5. JACOBSON E: Fatal immune thrombocytopenia induced by ethchlorvynol. Ann Intern Med 77:73-76, 1972 LinkGoogle Scholar6. P'AN S, KODET M, and GARDOCKI J: Pharmacologic studies on the hypnotic anticonvulsant actions of ethyl betachlorvinol ethinyl carbinol. J Pharmacol Exp Ther 114:326-333, 1955 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN C. KLOCK, M.D.Affiliations: Division of Hematology Department of Medicine University of California San Francisco San Francisco, California 94143 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySedativesEthchlorvynolSedative-HypnoticsBarbituriques et autres hypnotiques et sédatifsBarbiturates and Other Hypnotics and SedativesDiagnosis and Treatment of Drug OverdoseEthchlorvynol Ingestion: Interpretation of Blood Concentrations and Clinical FindingsThe effects of totigestational exposure to ethchlorvynol on development and behaviorA death due to ethchlorvynol abuse. A case reportResin Hemoperfusion for Treatment of Ethchlorvynol OverdoseROBERT I. LYNN, M.D., CHRISTINE L. HONIG, M.D., PETER I. JATLOW, M.D., ALAN S. KLIGER, M.D.Intravenous Ethchlorvynol-Induced Pulmonary EdemaEthchlorvynol (Placidyl⌖)-Induced Pulmonary EdemaFREDERICK L. GLAUSER, M.D., WILLIAM RICHARD SMITH, M.D., ALEX CALDWELL, M.D., MELVIN HOSHIKO, M.D., GEOFFREY S. DOLAN, M.D., HAROLD BAER, M.D., NEAL OLSHER, M.D. 1 July 1974Volume 81, Issue 1 Page: 131-132 Keywords Blood pressure Central nervous system Heart rate Idiopathic thrombocytopenic purpura Ingestion Respiration Suicide Temperature Toxicity ePublished: 1 December 2008 Issue Published: 1 July 1974 PDF downloadLoading ...