Inhaled Treprostinil for Treatment of Chronic Pulmonary Arterial Hypertension
Authors: Robert Voswinckel, Hossein A. Ghofrani, Friedrich Grimminger, Werner Seeger, Horst Olschewski
Journal: Annals of Internal Medicine (2006)

Letters17 January 2006Inhaled Treprostinil for Treatment of Chronic Pulmonary Arterial HypertensionRobert Voswinckel, MD, Hossein A. Ghofrani, MD, Friedrich Grimminger, MD, Werner Seeger, MD, and Horst Olschewski, MDRobert Voswinckel, MDFrom the University of Giessen Lung Center, 35392 Giessen, Germany, and Medical University Graz, 8036 Graz, Austria., Hossein A. Ghofrani, MDFrom the University of Giessen Lung Center, 35392 Giessen, Germany, and Medical University Graz, 8036 Graz, Austria., Friedrich Grimminger, MDFrom the University of Giessen Lung Center, 35392 Giessen, Germany, and Medical University Graz, 8036 Graz, Austria., Werner Seeger, MDFrom the University of Giessen Lung Center, 35392 Giessen, Germany, and Medical University Graz, 8036 Graz, Austria., and Horst Olschewski, MDFrom the University of Giessen Lung Center, 35392 Giessen, Germany, and Medical University Graz, 8036 Graz, Austria.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-2-200601170-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Treprostinil is a stable prostacyclin analogue that is approved for the treatment of pulmonary arterial hypertension when administered by continuous subcutaneous infusion (1). Inhalation of the stable prostacyclin analogue iloprost has proven clinical efficacy in patients with pulmonary hypertension in a randomized, controlled trial (2).Objective: To characterize the effects of inhaled treprostinil with special regard to safety, tolerability, and efficacy in patients with severe pulmonary arterial hypertension.Methods and Findings: Three patients with severe pulmonary hypertension underwent catheterization of the right heart and femoral artery for evaluation of pulmonary and systemic hemodynamics. The protocol consisted ...References1. Simonneau G, Barst RJ, Galie N, Naeije R, Rich S, Bourge RC, et al. Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: a double-blind, randomized, placebo-controlled trial. Am J Respir Crit Care Med. 2002;165:800-4. [PMID: 11897647] CrossrefMedlineGoogle Scholar2. Olschewski H, Simonneau G, Galie N, Higenbottam T, Naeije R, Rubin LJ, et al. Inhaled iloprost for severe pulmonary hypertension. N Engl J Med. 2002;347:322-9. [PMID: 12151469] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From the University of Giessen Lung Center, 35392 Giessen, Germany, and Medical University Graz, 8036 Graz, Austria.Disclosures: Consultancies: H.A. Ghofrani (LungRX), W. Seeger (LungRX), H. Olschewski (LungRX); Honoraria: H.A. Ghofrani (LungRX); Grants received: W. Seeger (LungRX). PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCorrection: Inhaled Treprostinil for Treatment of Chronic Pulmonary Arterial Hypertension Metrics Cited ByProstacyclin for pulmonary arterial hypertensionInhalation of repurposed drugs to treat pulmonary hypertensionInhaled treprostinil sodium for pulmonary hypertensionWHO Group 1 pulmonary arterial hypertension: Current and investigative therapiesInhaled treprostinil for the treatment of pulmonary arterial hypertensionPulmonary Hypertension in Older PatientsThe potential for inhaled treprostinil in the treatment of pulmonary arterial hypertensionAktuelle Therapie der pulmonal-arteriellen HypertonieFeasibility study of aerosolized prostaglandin E1 microspheres as a noninvasive therapy for pulmonary arterial hypertensionRole of Combination Therapy in the Treatment of Pulmonary Arterial HypertensionTherapie der pulmonalarteriellen HypertonieNovel approaches to the pharmacotherapy of pulmonary arterial hypertensionMetered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertensionAcute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertensionTherapeutic Challenges for Systemic Sclerosis: Facts and Future TargetsProstanoid Therapy for Pulmonary Arterial HypertensionInhalation therapy in invasive and noninvasive mechanical ventilationEffective inhaled drug administration to mechanically ventilated patientsPharmacologic treatment for pulmonary arterial hypertensionEmerging treatments for pulmonary arterial hypertensionFavorable Effects of Inhaled Treprostinil in Severe Pulmonary HypertensionPulmonary arterial hypertension and rheumatic diseases—from diagnosis to treatmentCorrection: Inhaled Treprostinil for Treatment of Chronic Pulmonary Arterial HypertensionProstacyclin for pulmonary hypertension in adults 17 January 2006Volume 144, Issue 2Page: 149-150KeywordsHeartHemodynamicsInhalationNitric oxideProstacyclinPulmonary hypertensionVasodilationVasodilatorsWalking ePublished: 17 January 2006 Issue Published: 17 January 2006 CopyrightCopyright © 2006 by American College of Physicians. 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