Granulomatous Disease in Common Variable Immunodeficiency
Authors: Jean-Francois Viallard
Journal: Annals of Internal Medicine (1998)

Letters1 May 1998Granulomatous Disease in Common Variable ImmunodeficiencyJean-Francois Viallard, MD, Jean-Luc Pellegrin, MD, and Jean-Francois Moreau, MD, PhDJean-Francois Viallard, MDUniversity of Bordeaux; 33604 Pessac, FranceSearch for more papers by this author, Jean-Luc Pellegrin, MDUniversity of Bordeaux; 33604 Pessac, FranceSearch for more papers by this author, and Jean-Francois Moreau, MD, PhDUniversity of Bordeaux; 33604 Pessac, FranceSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-9-199805010-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Mechanic and colleagues described 17 hypogammaglobulinemic patients with common variable immunodeficiency who had a granulomatous disease [1]. They found that 16 of 17 patients had deficient T-cell proliferation to mitogens, a finding suggesting that impaired T-cell function may lead to the abnormal sequestration of antigen and the subsequent formation of granulomas. In this regard the analysis of the γδ T cells, which are classically CD4- CD8- double-negative and whose involvement in granulomatous disease has already been shown [2], could be informative.As an example, we describe a 31-year-old woman in whom common variable immunodeficiency was diagnosed in ...References1. Mechanic LJ, Dikman S, Cunningham-Rundles C. Granulomatous disease in common variable immunodeficiency. Ann Intern Med. 1997; 127:613-7. Google Scholar2. Tamura N, Holroyd KJ, Banks T, Kirby M, Okayama H, Crystal RG. Diversity in junctional sequences associated with the common human Vγ9 and Vδ2 gene segments in normal blood and lung compared with the limited diversity in granulomatous disease. J Exp Med. 1990; 172:169-81. Google Scholar3. Moreau JF, Taupin JL, Dupon M, Carron JC, Ragnaud JM, Marimoutou C, et al. Increases in CD3+ CD4- CD8- T lymphocytes in AIDS patients with disseminated Mycobacterium avium-intracellulare complex infection. J Infect Dis. 1996; 174:969-76. Google Scholar4. Ladel CH, Hess J, Daugelat S, Mombaerts P, Tonegawa, Kaufmann SH. Contribution of αβ and γδ T-lymphocytes to immunity against Mycobacterium bovis bacillus Calmette Guérin studies with T cell receptor-deficient mutant mice. Eur J Immunol. 1995; 25:838-46. Google Scholar5. Kronenberg M. Antigens recognized by γδ T cells. Curr Opin Immunol. 1994; 6:64-71. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Bordeaux; 33604 Pessac, France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAtteintes respiratoires au cours du déficit immunitaire commun variable de l’adulteManagement of Autoimmunity and InflammationGranulomatous Disease in CVID: Retrospective Analysis of Clinical Characteristics and Treatment Efficacy in a Cohort of 59 PatientsManifestations digestives des déficits immunitaires primitifsCD8+HLA-DR+ T lymphocytes are increased in common variable immunodeficiency patients with impaired memory B-cell differentiationLe déficit immunitaire commun variable de l’adulte : étude clinique, biologique et immunologique chez 17 patients 1 May 1998Volume 128, Issue 9Page: 781-782KeywordsGiant cellsGranulomasImmunodeficienciesLymphocytesNontuberculous mycobacteriaPolymerase chain reactionProteinsT cell receptorsT cellsWeight loss Issue Published: 1 May 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...