tbuckley/cabot-search huggingface dataset:
P27 The Use Of Telemonitoring To Assist In The Early Supported Discharge For Patients Admitted With An Exacerbation Of Copd
Authors: G. Dawson, M. Collinge, J. Roberts, N. D. Bakerly
Journal: Thorax (2014)

<h3>Introduction</h3> In 2011 the Whole Systems Demonstrator programme findings showed that, if used correctly, Telehealth can deliver 14% reduction in bed days and an 8% reduction in tariff costs in patients with chronic conditions. However little data is available on using Telehealth to assist in the acute setting of early supported discharge of COPD patients as most previous studies focused on its use to assist the long term case management of these patients. <h3>Methods</h3> After training of staff within the COPD early support discharge (ESD) team in Salford (CAST), 17 HomePods were made available for this 12 months pilot starting in 2013. Patients were selected based on their ability to use the technology and on availability of HomePods. Pods were left with patients for 30 days and provided remote real-time monitoring of patients before they were re-deployed again to another patients. During the deployment period, patients were supported by a combination of telephone calls and home visits. <h3>Objectives</h3> Measure the impact of Telehealth on 30 day readmission rates in this cohort Test the impact of new technology on caseload/ work load of CAST Test the acceptability of Telehealth on this cohort and on CAST Asses impact on ability to selfcare Measure patients' satisfaction <h3>Outcomes</h3> – 73/285 (25%) patients received this intervention with the CAST team – 30 day re-admission rates within the intervention group was 3% compared to 8% in the other ESD patients, and 18% within the Respiratory directorate – Those in the telehealth group accounted for 5% of all home visits and 25% of all phone calls made by CAST – The capacity of CAST was increased from 15 Cases to 18 cases at any one time (20%) – Patients' survey showed excellent impact on Patients' satisfaction Confidence in self care Patients acceptability and likeability to Telehealth Good suggestions were made by patients for improvement <h3>Conclusions</h3> The use of Telehealth in the context of ESD for COPD patients admitted with an exacerbation appears to have favourable effect on relevant outcomes without impact on workload and therefore might me a useful tool to consider.
A Dominant-Negative p65 PAK Peptide Inhibits Angiogenesis
Authors: William B. Kiosses, John Hood, Suya Yang, Mary E. Gerritsen, David A. Cheresh, Nazilla Alderson, Martin Alexander Schwartz
Journal: Circulation Research (2002)

PAK1 is a protein kinase downstream of the small GTPases Rac and Cdc42 that previous work has implicated in endothelial cell migration via modulation of cell contraction. The first proline-rich region of PAK that binds to an SH3 domain from the adapter protein NCK was responsible for these dominant-negative effects. To test the role of PAK in angiogenesis, we prepared a peptide in which the proline-rich region was fused to the polybasic sequence from the HIV Tat protein to facilitate entry into cells. We show that the short peptide selectively binds NCK, whereas a mutant peptide does not. Treatment of cells with the PAK peptide but not the control peptide disrupts localization of PAK. This peptide specifically inhibited endothelial cell migration and contractility similarly to full-length dominant-negative PAK. In an in vitro tube-forming assay, the PAK peptide specifically blocked formation of multicellular networks. In an in vivo chick chorioallantoic membrane assay, the PAK peptide specifically blocked angiogenesis. These results, therefore, suggest a role for PAK in angiogenesis.
ECTOPIA VESICAE TREATED BY IMPLANTATION OF THE URETERS IN THE RECTUM
Authors: C. C. Holman
Journal: BMJ (1920)

ECTOPIA VESICAE is a sufficiently rare deformity to justify publication of the following case:A boy, aged 8 years, was admitted into the Nortbampton General Hospital in March, 1918, suffering from ectopia vesicae.He was small for his age and pale, exhibiting all the symptoms characteristic of his unhappy condition.First Operationi.On March 15tli, 1918, after the patient had been anaesthetized, a No. 1 gflm elastic catheter was passed into each ureter for
ABC of General Surgery in Children: NOTHING NEW
Authors: N H Naqvi
Journal: BMJ (1996)

Prediction of outcome of disease and risk assessment by a system of scoring has now been widely accepted in modern medicine. The concept is not new. Hippocrates wrote in Prognostica, “I hold that it is an excellent thing for a physician to practise forecasting.”

Substantial evidence of prognostic scoring was found in an Arabic manuscript—the MS 329 at the John Rylands University of Manchester library entitled The Sufficient in …
Noncontrast 3D CMR Imaging for Aortic Valve Annulus Sizing in TAVR
Authors: Ambarish Gopal, Paul A. Grayburn, Molly Mack, Isabel Chacon, Rebeca Kim, Debbie Montenegro, Teresa Phan, Jill Rudolph, Giovanni Filardo, Michael J. Mack, Deepika Gopalakrishnan
Journal: JACC. Cardiovascular imaging (2015)
A phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixafor
Authors: David H. McDermott, Qian Liu, Daniel Velez, Lizbeeth Lopez, Sandra Anaya-O’Brien, Jean Ulrick, Nana Kwatemaa, Judy Starling, Thomas A. Fleisher, Debra A. Long Priel, Melissa A. Merideth, Robert L. Giuntoli, Moses O. Evbuomwan, Patricia Littel, Martha M. Marquesen, Dianne Hilligoss, Rosamma DeCastro, George J. Grimes, Samuel T. Hwang, Stefania Pittaluga, Katherine R. Calvo, Pamela Stratton, Edward W. Cowen, Douglas B. Kuhns, Harry L. Malech, Philip M. Murphy
Journal: Blood (2014)
"Delusions" of Parasitosis Caused by Carpet Beetles
Authors: Samuel Ayres
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Dr. Kenneth M. Halprin is to be commended for his clear-cut description of the symptom complex familiar to dermatologists as delusions of parasitosis (<b>198</b>:1207, 1966). The classical picture is that of a harassed-looking patient on the verge of tears, usually a woman in her middle or later years, demanding more potent antiseptics to kill the parasites which she insists are infesting her skin, and presenting "specimens" which she has picked off her skin or her clothing. The skin is usually dry from vigorous scrubbing and applications of strong medication, and there are frequently crusted excoriations, gouges, and scars where the patient has attempted to dig out the hypothetical parasites. The dermatologist has been conditioned to one type of response to such a patient: reason and logic are useless, the quicker she is referred to a psychiatrist, the better, and microscopic examination of the "specimens" which she
Therapy of Obesity with Hormones
Authors: Richard S. Rivlin
Journal: New England Journal of Medicine (1975)

4 types of hormones used in the treatment of obesity are considered: human chorionic gonadotropin (HCG) thyroid hormones human growth hormone (HGH) and progesterone.  The efficacy of HCG is doubtful; in the treatment of childhool obesity the possible production of precocious puberty must be considered.  Thyroid hormones have had wide application.  Either thyroxine or tri-iodothyronine given in high doses for long periods produce transitory weight loss but follow-up studies show the patients regain the weight when therapy is stopped and that most of the loss consists of lean body mass  and relatively little body fat.  Cardiovascular symptoms are common during thyroid therapy.  Increased urinary calcium loss may constitute a health hazard.  Use of thyroid preparations is considered advisable only to replace levels in patients in whom hypothyroidism can be shown.  HGH can deplete body fat without producing much nitrogen loss; however limited supplies prevent wide application even for testing.  Progesterone therapy 100 mg im stimulates ventilation and improves the pulmonary status of obese patients who have a form of alveolar hypoventilation called te Pickwickian syndrome.  These patients have twitching cyanosis periodic respirations secondary polycythemia right ventricular hypertrophy and right ventricular failure.  Weight loss with progesterone therapy was not much.  Symptoms recurred when treatment was stopped.  Current pharmacologic approaches to the treatment of obesity are unsatisfactory.  Medications may be ineffective irrational or harmful.  More basic research is needed.
Hypertension with Intrarenal Arterial Aneurysm
Authors: Vincent J. O'Conor
Journal: New England Journal of Medicine (1960)

UNILATERAL renal disease, as a remediable cause of hypertension, has attracted much clinical interest since the suggestive studies of Goldblatt et al.1 in 1934. Since the initial clinical report by Butler2 in 1937, numerous patients with various forms of unilateral renal disease have undergone nephrectomy in an attempt to relieve hypertension. long-term results in the larger series, however, have not been impressive, the cure rate ranging from 19 to 24 per cent.3 , 4 In recent years, notably since the advent of translumbar aortography, attention has focused on lesions involving the renal vasculature, and it is in this group that a reasonable . . .
Mosaic Turner's Syndrome With Unusual Manifestations
Authors: Kang-Jey Ho
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Mosaic variants of Turner's syndrome have been reported to occur in about 20% of the cases and they show wide variations in their phenotypes.<sup>1-4</sup>This report represents a case of Turner's syndrome with mosaic chromosomal abnormalities and unusual manifestations such as normal ovaries, multiple cardiac anomalies, and partial situs inversus. To our knowledge, the latter two manifestations have not been reported previously. <h3>Report of a Case.—</h3> An infant weighing 2,500 gm was born at 36 weeks gastation on Dec 19, 1969, to a 31-year-old gravida 7, para 2, white mother. Bradycardia (40 to 60 beats per minute) of the baby had been noted in prenatal examinations. Moderate cyanosis, hepatosplenomegaly, and a grade 4/6 systolic murmur were present at birth. The Apgar score was 5. The baby had low-set ears, a low hair line, a short and webbed neck, a shield chest with widely spaced nipples, and
Fault and Default
Authors: Louis Lasagna
Journal: New England Journal of Medicine (1973)

In the Hippocratic writings, one reads: "...[the physician] should keep aware of the fact that patients often lie when they state that they have taken certain medicines."Obviously "noncompliance" or "drug defaulting" is nothing new. Why, then, are most doctors so insensitive to the possibility that their patients often do not follow directions? Cynics will propose that the physician is simultaneously imbued with his omniscience, omnipotence and authority and yet so insecure in these beliefs that he cannot coexist with the painful notion that his patients disobey or deceive him.But surely we all know doctors for whom this cynical . . .
PHOTOMETRIC MICRODETERMINATION OF HUMAN GAMMA GLOBULIN. I. DEVELOPMENT OF A QUANTITATIVE FLOCCULATION-NINHYDRIN PROCEDURE 1
Authors: Abraham Saifer, Michael C. Zymaris
Journal: Journal of Clinical Investigation (1952)

There are three general categories of procedures employed for the quantitative determination of the gamma globulin content of biological fluids. These are (1) electrophoretic methods, (2) chemical procedures, usually based on salt or organic solvent precipitation, and (3) immunochemical methods. A fourth class of procedures which are qualitative or semi-quantitative in nature, are the  flocculation reactions. These flocculation procedures are widely used in clinical work to determine changes in protein composition of disease sera, especially in gamma globulin, as compared to normal sera (1). The application of the electrophoretic technique of Tiselius to biological and medical problems has been fully discussed in recent review articles by Stern and Reiner (2), Luetscher (3) and Gutman (4). From a clinical viewpoint electrophoretic methods have the disadvantages of requiring relatively large amounts of protein material, expensive equipment, and skilled technical help and then permit only a few individual determinations to be per
Blue Blindness in Children: Fact or Fantasy?
Authors: Mark D. McAdams
Journal: JAMA (1975)

<h3>To the Editor.—</h3> A report (220:1425, 1972) discussing the findings of Sassoon and Tolder<sup>1</sup>indicated that a large percentage of young children have a deficiency of blue vision. In view of the apparent absence of any previous reports of blue vision anomalies in children and the serious implications for the early education of young children, we re-examined this question. We administered the AO H-R-R pseudoisochromatic plate test (American Optical Corp.) and the Farnsworth Panel D-15 test (The Psychological Corp.) to 413 children between 3 and 10 years old. The D-15 test involves the serial placement of 15 colored caps in a gradually changing color sequence, with a fixed reference cap providing the initial color. We found no blue-yellow vision failures with either the AO H-R-R or the D-15 test when the tests were scored by traditional methods. This result is consistent with the previously reported low incidence of blue
The Association between Weight Loss and Increased Longevity: A Review of the Evidence
Authors: David F. Williamson
Journal: Annals of Internal Medicine (1993)

Six published observational epidemiologic studies have reported evidence of reduced mortality rates in persons who have lost weight. In two studies, the reported protective effects of weight loss on mortality could not be justified by the data. In two other studies, weight loss was associated with both increased and decreased longevity in different subgroups. Only one study provided information on whether the weight loss was voluntary, but this study found similar effects of weight loss regardless of volition. These studies provided only limited information on the magnitude of weight loss associated with changes in longevity and no information on the types of methods used to achieve weight loss. Because of difficulties in studying long-term health outcomes related to obesity treatment, randomized, controlled trials are unlikely to provide a practical study design for this issue. Properly designed observational studies will probably provide the most useful information on the effects of voluntary weight loss on longevity.
FDA panel urges “black box” warning for antidepressants
Authors: Jeanne Lenzer
Journal: BMJ (2004)

All antidepressants should come with a “black box” label warning that adolescents treated with the drugs are more likely to become suicidal, according to an advisory panel to the US Food and Drug Administration.

Black box warnings are among the most stringent cautions issued by the FDA and are reserved for drugs with very serious or fatal side effects. The FDA generally follows the recommendations of advisory committees but is less likely to do so when the vote is split, as it was in this case (eight of the 23 expert panellists voted against the warning), said Dr Robert Temple, associate director for medical policy in the FDA's drug evaluation centre.

The surprise vote came after the presentation of new analyses by the FDA during two days of hearings on 13 and 14 September showing that children taking …
Australian public hospitals face only a residual role in elective surgery
Authors: C. Zinn
Journal: BMJ (2003)

Australians seeking elective surgery have been disenfranchised by the growth of private hospitals conducting such procedures and the retreat of public services, according to a report commissioned by the Royal Australasian College of Surgeons.

It found that public hospitals faced only a residual role in elective operations, such as hip and knee replacements, and the lack of access for patients without insurance (including more than half of those aged over 65), posed major equity issues.

The independent report said the swing to private care—caused by policies encouraging health insurance and by state and federal governments' reluctance to fund public hospitals properly—meant that patients without insurance would face longer waiting …
Low level hepatocyte proliferation and high viral load are associated with nuclear localization of hepatitis B core antigen (HBcAg)
Authors: H. Bozkaya, E. Erden, M. Varli, H. Çetinkaya, A. Kansu, K. Çinar, A.M. Bozdayi, S. Karayalcin, C. Yurdaydin, Ö. Uzunalimoǧlu
Journal: Journal of Hepatology (2000)
Lemonade: The Last Refreshing Taste
Authors: Roger C. Bone
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ventricular function of single ventricle after ventricular septation.
Authors: Y Shimazaki, Y Kawashima, T Mori, H Matsuda, S Kitamura, K Yokota
Journal: Circulation (1980)

In this report we describe the follow-up of two patients who underwent total correction (ven- tricular septation) of a Van Praagh type C single ventricle.At the time of this report the patients are 93 and 37 months after operation, have led a normal life and have nearly normal hemodynamics.Ventricular cavity volumes were estimated from biplane cineangiocardiogravns.In the first patient, left and right ventricular end-diastolic volume indexes (LVEDVI and RVEDVI) were 133 and 98 ml/m2, respectively.Left plus right ventricular end-diastolic volume (LVEDV + RVEDV) was approximately 136% of the sum of the normal values of the left and right ventricular volumes.The right-to-left ventricular end-diastolic volume ratio (RVEDV/LVEDV) was 0.74 and the right-to-left ventricular end-systolic volume ratio (RVESV/ LVESV) was 0.56.Ejection fractions of the left and right ventricles (LVEF and RVEF) were 0.50 and 0.61, respectively.In the second patient, LVEDVI and RVEDVI were 139 and 93 mI/M2, respectively.LVEDV + RVEDV was approximately 166% of the sum of the normal values of the left and right ventricular volumes.RVEDV/LVEDV and RVESV/LVESV were 0.67 and 0.50, respectively.LVEF and RVEF were 0.31 and 0.49, respectively.Cineangiocardiograms showed that the prosthetic ventricular septums shifted toward the right ventricle 7-9 mm in the systolic phase.This movement of the prosthetic septum made LVEF lower than RVEF.
INCIPIENT CATARACT; ITS ETIOLOGY, TREATMENT AND PROGNOSIS.Read in the Section on Ophthalmology, at the Forty-second Annual Meeting of the American Medical Association, held at Washington, D. C., May, 1891.
Authors: S. D. RISLEY
Journal: JAMA (1891)

In a brief paper published in the<i>University Medical Magazine</i>for March, 1889, I called attention to the underlying pathological factor in the etiology of<i>hard cataract</i>, and entered an urgent plea for the treatment of eyes afflicted with advancing opacity of the lens, before the stage of maturity. It was then claimed that by designating these cataracts as "senile" the tendency had been introduced to regard them as one of the unavoidable changes incident to the decline of life, and that by this means attention had been drawn away from other and more important factors in their production. It was shown that the hard and inelastic lens of even advanced life was not necessarily an opaque lens, and that approximately normal acuity of vision was quite compatible with old age. That the opaque lens was therefore an extraordinary occurrence to be explained by other causes than senility. In my
Therapeutic potential of inhibiting leukocyte rolling in ischemia/reperfusion.
Authors: P Kubes, M Jutila, D Payne
Journal: Journal of Clinical Investigation (1995)

Leukocyte rolling has been postulated to be mandatory for subsequent leukocyte adhesion and tissue injury observed during ischemia/reperfusion. The objective of this study was to systematically assess this hypothesis at the microvascular level by examining the effects of various concentrations of a selectin-binding carbohydrate (fucoidin) on the increased rolling and adhesion of leukocytes in postischemic venules. The contribution of L-selectin and/or P-selectin to leukocyte rolling were also assessed in this model. Using intravital microscopy we observed that 60 min of ischemia followed by reperfusion caused a profound increase in leukocyte rolling and adhesion. A high dose of fucoidin (25 mg/kg) reduced leukocyte rolling by > 90% and significantly reduced leukocyte adhesion, whereas a lower dose of fucoidin still reduced leukocyte rolling by 60% but had no effect on leukocyte adhesion. Moreover, despite the profound reduction in leukocyte rolling with fucoidin, the remaining rolling cells were able to firmly adhere via a CD18-dependent mechanism, particularly in those postcapillary venules with reduced (30-50%) shear rates. The increased rolling was also reduced 60% by either an anti-P-selectin antibody, an anti-L-selectin antibody, or a combination of the two antibodies, but this reduction in rolling cells did not translate into significantly reduced leukocyte adhesion. Our data suggest that L-selectin, P-selectin, and a fucoidin-sensitive pathway contribute to the significant increase in reperfusion-induced leukocyte rolling. However, targeting leukocyte rolling as a form of therapy requires very significant efficacy (> 90%) to achieve reasonable (approximately 50%) attenuation in leukocyte adhesion in postischemic venules.