tbuckley/cabot-search huggingface dataset:
Nitroprusside Toxicity and Low-Dose Infusion
Authors: ANNE B. CETNAROWSKI
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 June 1986Nitroprusside Toxicity and Low-Dose InfusionANNE B. CETNAROWSKI, Pharm.D., DAVID R. CONTI, M.D.ANNE B. CETNAROWSKI, Pharm.D.Search for more papers by this author, DAVID R. CONTI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-6-895_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Sodium nitroprusside is used extensively in the treatment of various cardiovascular emergencies. The toxicity profile of this drug requires frequent assessment of patients for signs of cyanide and thiocyanate toxicity, which may be elusive in view of concurrent diseases and medications. Prolonged infusions at doses well below the manufacturer's recommendations for maximum infusion rate, 10 µg/kg body weight ·min, are known to produce toxic accumulation of cyanide and thiocyanate (1, 2). We noted sodium nitroprusside toxicity at a dose rate that was 4 µg/kg · min or more for 14 hours, with a maximum rate of 4.9...References1. SCHULZGROSSPASCHLOESCHCKE VRTG. Cyanide toxicity of sodium nitroprusside in therapeutic use with and without sodium thiosulphate. Klin Wochenschr. 1982;60:1393-400. CrossrefMedlineGoogle Scholar2. RIEVES D. Importance of symptoms in recognizing nitroprusside toxicity. South Med J. 1984;77:1035-7. CrossrefMedlineGoogle Scholar3. VESEYCOLE CP. Blood cyanide and thiocyanate concentration produced by long-term therapy with sodium nitroprusside. Br J Anaesth. 1985;57:148-55. CrossrefMedlineGoogle Scholar4. PASCHSCHULZHOPPELSHAUSER TVG. Nitroprusside-induced formation of cyanide and its detoxication with thiosulfate during deliberate hypotension. J Cardiovasc Pharmacol. 1983;5:77-84. CrossrefMedlineGoogle Scholar5. GREISSTREMBLAYDAVIES LND. The toxicity of sodium nitroprusside. Can Anaesth Soc J 1976;23:480-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ANNE B. CETNAROWSKI, Pharm.D.; DAVID R. CONTI, M.D.Affiliations: Millard Fillmore Hospital Buffalo, NY 14209 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCyanide Toxicity in the Surgical Intensive Care Unit: A Case ReportTreatment of Hypertension in the Perioperative PatientRandomized, Prospective Trial of Fenoldopam vs Sodium Nitroprusside in the Treatment of Acute Severe HypertensionTreatment of Cyanide and Thiocyanate Toxicity Secondary to Sodium NitroprussideCyanide Toxicity from Sodium Nitroprusside: Risks and ManagementCyanide release from sodium nitroprusside during coronary bypass in hypothermiaComparative acute blood pressure reduction from intravenous fenoldopam mesylate versus sodium nitroprusside in severe systemic hypertension 1 June 1986Volume 104, Issue 6Page: 895-896KeywordsAdverse reactionsBody weightSodiumToxicity ePublished: 1 December 2008 Issue Published: 1 June 1986 PDF downloadLoading ...
Malignant Langerhans cell tumour
Authors: M. TANI, N. ISHII, M. KUMAGAI, M. BAN, A. SASASE, Y. MISHIMA
Journal: British Journal of Dermatology (1992)

Journal Article Malignant Langerhans cell tumour Get access M. TANI, M. TANI Department of Dermatology, Kobe University School of Medicine, 5 Kusunoki‐cho, 7 chome, Chuo‐ku, Kobe 650, Japan Dr M.Tani. Search for other works by this author on: Oxford Academic Google Scholar N. ISHII, N. ISHII Department of Dermatology, Kobe University School of Medicine, 5 Kusunoki‐cho, 7 chome, Chuo‐ku, Kobe 650, Japan Search for other works by this author on: Oxford Academic Google Scholar M. KUMAGAI, M. KUMAGAI Department of Dermatology, Kobe University School of Medicine, 5 Kusunoki‐cho, 7 chome, Chuo‐ku, Kobe 650, Japan Search for other works by this author on: Oxford Academic Google Scholar M. BAN, M. BAN Department of Dermatology, Kobe University School of Medicine, 5 Kusunoki‐cho, 7 chome, Chuo‐ku, Kobe 650, Japan Search for other works by this author on: Oxford Academic Google Scholar A. SASASE, A. SASASE Department of Dermatology, Kobe University School of Medicine, 5 Kusunoki‐cho, 7 chome, Chuo‐ku, Kobe 650, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. MISHIMA Y. MISHIMA Department of Dermatology, Kobe University School of Medicine, 5 Kusunoki‐cho, 7 chome, Chuo‐ku, Kobe 650, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 126, Issue 4, 1 April 1992, Pages 398–403, https://doi.org/10.1111/j.1365-2133.1992.tb00689.x Published: 01 April 1992
Giant-Cell Arteritis
Authors: L.A. HEALEY
Journal: Annals of Internal Medicine (1978)

Editorial Notes1 May 1978Giant-Cell ArteritisL.A. HEALEY, M.D., F.A.C.P.L.A. HEALEY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-5-710 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough Horton described temporal arteritis in 1932, the syndrome did not get much attention until the past decade. As shown by the epidemiologic study of Huston and colleagues, reported in this journal 3 months ago (1), it is not a rare disease in elderly persons. Best known is the picture of temporal arteritis: An elderly patient has severe headache, tender thickened temporal artery, and a very rapid erythrocyte sedimentation rate. But the disease is not localized to the temporal artery. Arteriographic studies and postmortem examinations have shown that the giant-cell inflammation may involve the aorta, its branches, and any medium-...References1. HUSTONHUNDERLIEKENNEDYELVEBACK KGJRL: Temporal arteritis. A 25-year epidemiologic, clinical, and pathologic study. Ann Intern Med 88:162-167, 1978 LinkGoogle Scholar2. KLEINHUNDERSTANSONSHEPS RGAS: Large artery involvement in giant cell (temporal) arteritis. Ann Intern Med 83:806-812, 1975 LinkGoogle Scholar3. PARKERHEALEYWILSKEODLAND FLKG: Light and electron microscopic studies on human temporal arteries with special reference to alterations related to senescence, atherosclerosis and giant cell arteritis. Am J Pathol 79:57-80, 1975 MedlineGoogle Scholar4. WILKINSONRUSSELL IR: Arteries of the head and neck in giant cell arteritis. A pathological study to show the pattern of arterial involvement. Arch Neurol 27:378-391, 1972 CrossrefMedlineGoogle Scholar5. HEALEYWILSKE LK: Manifestations of giant cell arteritis. Med Clin North Am 61:261-270, 1977 CrossrefMedlineGoogle Scholar6. HAZLEMANMACLENNANESIRI BIM: Lymphocyte proliferation to artery antigen as a positive diagnostic test in polymyalgia rheumatica. Ann Rheum Dis 34:122-127, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Mason Clinic Seattle, Washington PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByGiant Cell Arteritis☆Head and neck manifestations of autoimmune diseaseFatal Neurological Complications in Temporal Arteritis: An Unusual CaseREFERENCESRealistic guidelines of corticosteroid therapy in rheumatic diseaseSOLAR AND RADIANT DAMAGE TO ELASTIC TISSUE AS A CAUSE OF INTERNAL VASCULAR DISEASE 1 May 1978Volume 88, Issue 5Page: 710-710KeywordsAortaArteriesAutopsyElderlyEpidemiologyErythrocyte sedimentation rateHeadachesInflammationTemporal arteritis Issue Published: 1 May 1978 PDF DownloadLoading ...
Acute Thyroiditis Associated with Adenovirus Infection.
Authors: Nat H. Swann
Journal: Annals of Internal Medicine (1964)

s1 October 1964Acute Thyroiditis Associated with Adenovirus Infection.Nat H. Swann, M.D.Nat H. Swann, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-812_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcute nonsuppurative thyroiditis was first described in 1896 and during the past 60-odd years we have learned little more about this disease than was previously known. There has been increased interest during the past few years and more cases are being recognized. The multiplicity of synonyms, the dispute as to etiology, and the many methods of treatment illustrate our confusion. Seventeen cases of acute thyroiditis were seen during two distinct outbreaks separated by several months—no cases were recognized during the intervening months. Serum for complement fixation studies for adenovirus was obtained on one patient during the initial outbreak and showed... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chattanooga, Tenn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1964Volume 61, Issue 4Page: 812-812KeywordsEtiologyThyroid Issue Published: 1 October 1964 PDF downloadLoading ...
Dialysis disequilibrium syndrome (DDS) in the rat: Role of the “reverse urea effect”
Authors: Stephen M. Silver, Joseph A. DeSimone, Denise A. Smith, Richard H. Sterns
Journal: Kidney International (1992)

DDS is characterized by neurologic deterioration and cerebral edema which occurs after hemodialysis. To investigate the pathogenesis of DDDS, we studied the effects of rapid hemodialysis on plasma and brain electrolytes, urea, and osmolality in the rat. Forty-two hours after bilateral nephrectomy, nine uremic rats were hemodialyzed for 90 minutes against dialysate without urea (model of DDS), yielding a decrease in plasma urea from 72 +/- 2 mM to 34 +/- 2 mM (P less than 0.01) and an 8% (29 mOsm/kg) decrease in plasma osmolality. This group was compared to three control groups: 11 uremic animals dialyzed against a bath with urea added so that no fall in plasma urea occurred, and 15 uremic and 12 nonuremic animals that were not dialyzed. In animals dialyzed without urea, compared to uremic non-dialyzed animals, there was a 6% increase in brain water (3.89 +/- 0.04 liter/kg dry wt vs. 3.67 +/- 0.03, P less than 0.01) and an increase in the brain to plasma (urea) ratio (1.30 +/- 0.06 vs. 0.79 +/- 0.05, P less than 0.01). Comparison of these parameters in animals dialyzed without urea versus other control groups yielded similar results. In animals dialyzed without urea, the 53% decrease in plasma urea was associated with only a 13% decrease in brain urea content. Brain content of sodium and potassium was not significantly different among groups. Retention of brain urea despite the large decrease in plasma urea was able to account for the increased brain water observed in animals dialyzed without urea.(ABSTRACT TRUNCATED AT 250 WORDS)
Negative feedback regulation of T helper type 1 (Th1)/Th2 cytokine balance via dendritic cell and natural killer T cell interactions
Authors: Keita Minami, Yoshiki Yanagawa, Kazuya Iwabuchi, Nobuo Shinohara, Toru Harabayashi, Katsuya Nonomura, Kazunori Onoé
Journal: Blood (2005)
Cyclophosphamide-Induced Bladder Cancer
Authors: Jan Gossmann
Journal: Annals of Internal Medicine (1997)

Letters1 January 1997Cyclophosphamide-Induced Bladder CancerJan Gossmann, MDJan Gossmann, MDKlinikum der J.W. Goethe-Universitat; Frankfurt, Main, GermanySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-1-199701010-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The study by Talar-Williams and colleagues [1] on cyclophosphamide-induced cystitis and bladder cancer in patients with Wegener granulomatosis, which had an extensive follow-up on a large group of patients, may help define the incidence of clinically detectable bladder cancer in these patients. However, the authors' statement that nonglomerular hematuria is a risk factor for this disease may be biased because only patients with nonglomerular hematuria had cystoscopy; the other 72 patients in the cohort did not. Therefore, the true incidence of bladder cancer or cyclophosphamide-induced bladder injury in those 72 patients remains unknown, because in as many ...References1. Talar-Williams C, Hijazi YM, McClellan MW, Linehan WM, Hallahan CW, Lubensky I, et al. Cyclophosphamide-induced cystitis and bladder cancer in patients with Wegener granulomatosis. Ann Intern Med. 1996; 124:477-84. Google Scholar2. Garnick MB, Brenner BM. Tumors of the urinary tract. In: Wilson JD, Braunwald E, Isselbacher KJ, Petersdorf RG, Martin JB, Fauci AS, et al, eds. Harrison's Principles of Internal Medicine. 12th ed. New York: McGraw-Hill; 1991:1209-12. Google Scholar Author, Article, and Disclosure InformationAuthors: Jan Gossmann, MDAffiliations: Klinikum der J.W. Goethe-Universitat; Frankfurt, Main, Germany PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChildhood Cancer Survivorship 1 January 1997Volume 126, Issue 1Page: 86KeywordsBladderBladder cancerCyclophosphamideCystitisCystoscopyMedical risk factorsWegener granulomatosis ePublished: 15 August 2000 Issue Published: 1 January 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Kyoto agreement on greenhouse gases receives mixed response
Authors: T. Richards
Journal: BMJ (1998)

The eleventh hour agreement that industrialised countries must reduce their collective emissions of greenhouse gases by 5.2% has received a mixed reaction.

On the face of it, the deal—reached at the third United Nations convention on climate change in Kyoto—looks good. After 10 days of wrangling by the 2200 official delegates and thousands of observers and lobbyists from 160 countries, a legally binding agreement was finally reached on 11 December. The agreement aims to lower overall emissions from six greenhouse gases by 2008-12. Cuts in the three most important greenhouse gases – carbon dioxide, methane, and nitrous oxide – will be measured against 1990 values.

Assuming that the agreement is ratified by national governments and that the 38 countries that have agreed to curb emissions do so, then the overall reduction of greenhouse gas emissions should be nearer 10% because many industrialised countries have not yet met their 1992 (non-legally binding) targets. If the cuts are compared to …
Reply to Emanuele Casciani, Luca Bertini and GianFranco Gualdi's Letter to the Editor re: Alessandro Sciarra, Valeria Panebianco, Stefano Salciccia, et al. Role of Dynamic Contrast-Enhanced Magnetic Resonance (MR) Imaging and Proton MR Spectroscopic Imaging in the Detection of Local Recurrence after Radical Prostatectomy for Prostate Cancer. Eur Urol 2008;54:589–600
Authors: Valeria Panebianco, Roberto Passariello
Journal: European Urology (2008)
Industrial Support of Biomedical Publications
Authors: Alfred Soffer
Journal: JAMA (1983)

The mail each morning brings an announcement of a symposium, seminar, or postgraduate course presented by a pharmaceutical firm or medical device company. In everincreasing numbers, the proceedings of these regional or national educational programs appear in published form in clinical medical journals or as a special issue or supplement to these periodicals. In almost every instance, the total cost for the printing and mailing of the published version is supported by an industrial grant. Does the publication of such material constitute a constructive symbiotic relationship between industry and the scientific community, or do the proceedings really represent thinly disguised promotional efforts? If issues of integrity are at stake, can editorial boards provide reasonable guidelines, or should all offers of industrial funding for publications be rejected? These issues were discussed recently during an evening of candid dialogue among a group of clinical editors from the United States, Canada, Great Britain,
IMPORTANCE OF ESOPHAGEAL EXFOLIATIVE CYTOLOGY IN ACHALASIA
Authors: WILLIAM M. LUKASH
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 February 1969IMPORTANCE OF ESOPHAGEAL EXFOLIATIVE CYTOLOGY IN ACHALASIAWILLIAM M. LUKASH, M.D., RAYMOND B. JOHNSON, M.D.WILLIAM M. LUKASH, M.D.Search for more papers by this author, RAYMOND B. JOHNSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-2-420_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: The recent article, "Esophageal Achalasia Probably Due to Gastric Carcinoma," by Kolodney and associates (1) emphasizes that carcinoma involving the esophagus or the proximal portion of the stomach can affect esophageal innervation, producing the features characteristic of achalasia. We have had two patients, one age 46 and the other age 76, in whom the characteristic roentgenographic, clinical, and endoscopic features of achalasia were seen (Figure 1). Also, both patients responded positively to a Mecholyl® testand to a dose of effervescent Bromo-Seltzer®. In neither patient did esophagoscopy and biopsy of esophageal tissue show any evidence of malignancy....References1. KOLODNYSCHRADERRUBINHOCHMANSLEISENGER MZRWRMH: Esophageal achalasia probably due to gastric carcinoma. Ann. Intern. Med. 69: 569, 1968. LinkGoogle Scholar2. YOUNGSNIELSEN LAOF: Application of membrane-filter technique to esophageal and gastric cytology. Milit. Med. 130: 887, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Gastroenterology Naval Hospital National Naval Medical Center Bethesda, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExfoliative Cytology of the Esophagus 1 February 1969Volume 70, Issue 2Page: 420-421KeywordsBiopsyCell biologyEsophagusStomach Issue Published: 1 February 1969 PDF downloadLoading ...
Insight alone was not enough
Authors: M. Riddall
Journal: BMJ (2000)

Three years ago the General Medical Council (GMC) suspended me from the medical register for one year for the emotional abuse of a therapeutic relationship with a 17 year old man. The original charge had included the words “and sexual,” but this was dropped.

> I wish that the health committee had been empowered at the time of my initial suspension 

My mistake was to think that insight alone was enough, and that my job satisfaction could be based on the special understanding that I felt I had with each patient—an understanding of his or her problem, illness, personality, or own view on life. The majority of my patients collaborated eagerly with this approach, but I suspect that those who did not found me extremely irritating.

> I drank heavily, spent life savings, developed overinflated ideas of my own abilities 

Although I paid lip service to discussion and audit, my …
A Portable Medical Record System for the Elderly
Authors: Fredrick T. Sherman
Journal: JAMA (1979)

A portable medical record system consisting of a bracelet and wallet card, was given to two groups of ambulatory, chronically ill, mentally clear, older patients. Group 1 included 23 patients discharged from a skilled nursing facility and treated in the community; group 2, 24 patients attending the outpatient department of an acute general teaching hospital. Biweekly follow-up telephone calls to patients and subsequent discussions with physicians demonstrated the usefulness of this system in predominantly nonemergency settings. Overall, the physicians noticed the bracelet during 46% of the visits and the wallet card during 28%. Group 2 physicians, however, noticed the bracelet and/or wallet card more frequently than did group 1 physicians. Reasons for the difference in recognition among the two groups and the implications for future use of a portable medical record system for the elderly are discussed.
Cytokine gene expression in cirrhotic and non-cirrhotic human liver
Authors: Luis Llorente, Yvonne Richaud-Patin, Natasha Alcocer-Castillejos, Rodrigo Ruiz-Soto, Miguel Angel Mercado, Hécto Orozco, Armando Gamboa-Domínguez, Jorge Alcocer-Varela
Journal: Journal of Hepatology (1996)
Attitudes of Hospital Leaders Toward Publicly Reported Measures of Health Care Quality
Authors: Peter K. Lindenauer, Tara Lagu, Joseph S. Ross, Penelope S. Pekow, Amy Shatz, Nicholas Hannon, Michael B. Rothberg, Evan M. Benjamin
Journal: JAMA Internal Medicine (2014)

Public reporting of quality is considered a key strategy for stimulating improvement efforts at US hospitals; however, little is known about the attitudes of hospital leaders toward existing quality measures.To describe US hospital leaders' attitudes toward hospital quality measures found on the Centers for Medicare & Medicaid Services' Hospital Compare website, assess use of these measures for quality improvement, and examine the association between leaders' attitudes and hospital quality performance.We mailed a 21-item questionnaire from January 1 through September 31, 2012, to senior hospital leaders from a stratified random sample of 630 US hospitals, including equal numbers with better-than-expected, as-expected, and worse-than-expected performance on mortality and readmission measures.We assessed levels of agreement with statements concerning quality measures, examined use of measures for improvement activities, and analyzed the association between leaders' attitudes and hospital performance.Of 630 hospitals surveyed, 380 (60.3%) responded. For each of the mortality, readmission, process, and patient experience measures, more than 70% of hospitals agreed with the statement that "public reporting stimulates quality improvement activity at my institution"; agreement for measures of cost and volume was 65.2% and 53.3%, respectively. A similar pattern was observed for the statement that "our hospital is able to influence performance on this measure"; agreement for processes of care and patient experience measures was 96.4% and 94.2%, respectively. A total of 89.7% of hospitals agreed that the hospital's reputation was influenced by patient experience measures; agreement was 77.4% for mortality, 69.9% for readmission, 76.3% for process measures, 66.1% for cost measures, and 54.0% for volume measures. A total of 87.1% of hospitals reported incorporating performance on publicly reported measures into their hospital's annual goals, whereas 90.2% reported regularly reviewing the results with the hospital's board of trustees and 94.3% with senior clinical and administrative leaders. When compared with chief executive officers and chief medical officers, respondents who identified themselves as chief quality officers or vice presidents of quality were less likely to agree that public reporting stimulates quality improvement and that measured differences are large enough to differentiate among hospitals.Hospital leaders indicated that the measures reported on the Hospital Compare website exert strong influence over local planning and improvement efforts. However, they expressed concerns about the clinical meaningfulness, unintended consequences, and methods of public reporting.