tbuckley/cabot-search huggingface dataset:
Assessing Cardiovascular Risk Factors in National Football League Players
Authors: Neil Coplan
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hemodynamic consequences of combined beta-adrenergic and slow calcium channel blockade in man.
Authors: M Packer, J Meller, N Medina, M Yushak, H Smith, J Holt, J Guererro, G D Todd, R G McAllister, R Gorlin
Journal: Circulation (1982)

The administration of verapamil to patients receiving beta-adrenergic blocking drugs is reported to produce adverse circulatory reactions, but a systematic investigation of this potential drug interaction has not been performed in man. We administered 40-, 80- and 120-mg doses of verapamil orally to 15 patients with angina pectoris who were receiving high doses of propranolol or metoprolol. Verapamil produced dose-dependent decreases in cardiac performance: with 120 mg, cardiac index decreased by 0.38 l/min/m2, stroke volume index decreased by 2.8 ml/beat/m2 and heart rate decreased by 6 beats/min, associated with increases in pulmonary capillary wedge (2.2 mm Hg) and mean right atrial pressures (1.7 mm Hg) (all p less than 0.01); two patients had marked, but asymptomatic, hypotensive reactions. In contrast, repeat administration of 120-mg doses of verapamil 24--30 hours after withdrawal of beta blockade produced no significant cardiodepressant effects despite significantly higher plasma levels of verapamil than during propranolol therapy (383.1 vs 205.1 ng/ml, p less than 0.01). In conclusion, verapamil produces significant negative inotropic and chronotropic effects in patients treated with beta-adrenergic antagonists; combination therapy should therefore be used with caution in patients with angina pectoris.
Non–T-cell–depleted HLA haploidentical stem cell transplantation in advanced hematologic malignancies based on the feto-maternal michrochimerism
Authors: Chihiro Shimazaki, Naoya Ochiai, Ryo Uchida, Akira Okano, Shin-ichi Fuchida, Eishi Ashihara, Tohru Inaba, Naohisa Fujita, Etsuko Maruya, Masao Nakagawa
Journal: Blood (2003)
Abstract 2228: Folate-related genes polymorphism and risk of pediatric acute lymphoplastic leukemia
Authors: Nermin Raafat, Amal Gharib, Usama Elsafy, Tamer Hassan
Journal: Cancer Research (2014)

Abstract Background: Childhood acute lymphoblastic leukemia (ALL) is the most common malignancy affecting children, constituting about 30% of all cancers among children. It constitutes about 75% of pediatric acute leukemia with peak incidence between ages 3 and 4. The assertion that ALL may have a genetic basis has long been pursued through association studies based on candidate genes as folate metabolism. Polymorphisms in folate pathway genes may influence the susceptibility to acute lymphoblastic leukemia. Increased risk of ALL was observed in reduced folate carrier protein (RFC1) 80GA variant carriers. A 1.4-fold reduction in ALL risk was observed for carriers of the methyl tetrahydrofolate reductase (MTHFR) 677T allele. Objectives: this study was carried out to evaluate the contribution of MTHFR C677T and RFC1 80GA gene polymorphism and susciptability of childhood acute lymphoblastic leukemia. Materials &amp;Methods: DNA was isolated from 200 children, divided into 2 groups, group I included 100 pediatric ALL patients and group II included 100 healthy donors as controls. Genotyping of MTHFR C677T and RFC1 G80A was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using Hinf I and HhaI restriction endonuclease respectively. Results: MTHFR 677T allele carriers were significantly lower in ALL cases (46%) than healthy controls (56%). Reduction in ALL risk was observed for heterozygous (CT) or homozygous (TT) carriers of the MTHFR 677T allele (OR 0.8; 95% CI, 0.9-1.5; P &amp;lt; 0.002). RFC1 80A allelic carriers have an increased susceptibility to ALL. Risk was increased 2.0 times (OR 3.5; 95% CI, 1.5-4.8 ; P .02) for A-allelic carriers. Conclusion: our data suggested that the MTHFR gene variants are associated with decreased ALL rate and risk. the reduced risk associated with the MTHFR C677T polymorphisms may be the result of changed intracellular folate redistribution. the results of our study also supported the suggestion that RFC1 G80A RFC1 G80A single nucleotide polymorphism contributed to increase the susceptibility and the development of pediatric ALL. Citation Format: Nermin Raafat, Amal Gharib, Usama Elsafy, Tamer Hassan. Folate-related genes polymorphism and risk of pediatric acute lymphoplastic leukemia. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2228. doi:10.1158/1538-7445.AM2014-2228
Reviews, Notes, and Listings: Infectious Disease Medicine: Medical Mycology
Authors: James W. Smith
Journal: Annals of Internal Medicine (1993)

Literature of Medicine15 June 1993Reviews, Notes, and Listings: Infectious Disease Medicine: Medical MycologyJames W. Smith, MDJames W. Smith, MDDallas Veterans Affairs Medical Center, Dallas, TX 75126.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-12-199306150-00038 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Medical MycologyK. J. Kwon-Chung and John E. Bennett. 375 pages. Philadelphia: Lea & Febiger; 1992. $69.50.Medical management of patients with fungal infections requires not only a knowledge of their clinical course and multisystem manifestations but also the ability to interpret pathologic specimens and mycologic smears and cultures. Although textbooks of medicine have recently devoted more space to these infections, a textbook of medical mycology is the source for specific information on clinical and cultural characteristics of these pathogens. The standard for the microbiologic characteristics of these pathogens is the new text by Kwon-Chung and Bennett. This updated version was edited ... Author, Article, and Disclosure InformationAffiliations: Dallas Veterans Affairs Medical Center, Dallas, TX 75126. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 June 1993Volume 118, Issue 12Page: 992KeywordsAntifungalsChemotherapyEpidemiologyFungal pathogensInfectious diseasesMicrobiologyMitesMycologyPathologistsResearch laboratories ePublished: 15 August 2000 Issue Published: 15 June 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Is antitumour necrosis factor therapy combined with ultraviolet B phototherapy safe?
Authors: V. Di Lernia, G. Albertini
Journal: British Journal of Dermatology (2010)

Conflicts of interest: none declared. madam, Wolf et al.1 found that psoriasis in patients on the tumour necrosis factor (TNF) antagonist etanercept improved more on body halves treated additionally with narrow‐band ultraviolet B (NB‐UVB) phototherapy. Previously, other authors had considered this combination treatment to be efficacious and safe in a 12‐week, single‐arm, open‐label study in 86 patients affected by moderate to severe psoriasis.2 NB‐UVB monotherapy has not been directly compared with etanercept or with the etanercept plus NB‐UVB combination. Although UVB irradiation can rapidly induce TNF‐α expression in both keratinocytes, the main cells of the epidermis and major targets of UVB irradiation, and dermal fibroblasts,3 our clinical experience supports the conclusion of the authors that UVB phototherapy may improve the response to etanercept. Indeed, a significant proportion of patients with psoriasis does not achieve a complete, or even an acceptable, response after treatment with biologic agents. In such cases, two approaches to improving the overall therapeutic response are (i) to reduce the intervals between drug administrations, or (ii) to combine biologic drugs (commonly infliximab or etanercept) with conventional therapies (e.g. acitretin, methotrexate or, less often, ciclosporin).
An Increase in the Number of Deaths in the United States in the First Week of the Month — An Association with Substance Abuse and Other Causes of Death
Authors: David P. Phillips, Nicholas Christenfeld, Natalie M. Ryan
Journal: New England Journal of Medicine (1999)

There are regular changes in mortality rates, such as increased rates of death from influenza in the winter and from motor vehicle accidents on long holiday weekends. Previous research has shown that among persons with schizophrenia, the rates of cocaine use and hospital admissions increase at the beginning of the month, after the receipt of disability payments. Using computerized data from all death certificates in the United States between 1973 and 1988, we compared the number of deaths in the first week of the month with the number of deaths in the last week of the preceding month.
Letter by Asosingh et al Regarding Article, “Circulating Endothelial Progenitor Cells in Patients With Eisenmenger Syndrome and Idiopathic Pulmonary Arterial Hypertension”
Authors: Kewal Asosingh, Serpil C. Erzurum, Mervin C. Yoder, Rubin M. Tuder
Journal: Circulation (2009)
Men and Moments in the History of Science
Authors: William B. Bean
Journal: JAMA (1961)

To help celebrate the 25th anniversary of the History of Science Dinner Club Dr. Evans brought out this volume. The essays collected in this book were read at meetings of the club. Their subjects range far and wide over the broad realms of science. Unfortunately their date of delivery is not recorded, so it is not always possible to tell whether any oversight or omission represents failure to correct the essays in the light of recent developments or represents unawareness. One sees beautifully developed the interchange of ideas and the mutual stimulus which scientific workers share in Koenig's very revealing researches "On the History of Science and of the Second Law of Thermodynamics." The contributions and influence of Carnot, Clausius, and Thomson on the development of ideas and the close temporal association or simultaneity of independent discoveries when the intellectual climate is favorable are illustrated clearly and convincingly. Another essay
160. Innate Immune Responses to Viral Vectors Are Modulated by Complement Inhibitors in an Ex Vivo Model Using Whole Human Blood
Authors: Lindsay J. Stanbridge, Graciela Elgue, Javier Sanchez, Vincent Dussupt, Lucy C. Hudson, John D. Lambris, Thomas Totterman, Norman J. Maitland, Bo Nilsson
Journal: Molecular Therapy (2006)

Survival of gene therapy vectors in the bloodstream, in the presence of cells and proteins of the immune response, is vital for a variety of therapeutic applications. Complement has previously been shown to be activated by a variety of gene therapy vectors. An inflammatory response in blood has been reported in response to adenovirus, but has yet to be demonstrated with baculovirus vectors (bv). A blood 'loop' model was used to study human innate immunity to an AcMNPV bv vector in three healthy volunteers and to assess the effects of two complement inhibitors, Compstatin and C5a receptor antagonist (C5aRA). Fresh non-anticoagulated blood from 3 human volunteers was inoculated with bv samples and circulated in heparin-coated PVC tubing for 4 hours at 37°C. Plasma samples were extracted at different time-points and analysed for evidence of immune activation. The complement system was activated by bv within 15 minutes as reflected by formation of C3a and C5b-9, except in the presence of Compstatin. Serum C3 fragments and IgM, but not IgG, could bind to bv particles. Production of TNF-α, IL-8 and IL-6 was stimulated within two hours and IL-1β within 4 hours, and the effects of complement inhibitors were variable between volunteers. Activation of the clotting cascade in the presence of virus was prevented by either complement inhibitor, but only Compstatin promoted survival of infectious vector. After 2 hours incubation with blood, virus was found both in the plasma and associated with various cell types. This is the first comprehensive study of innate immunity to bv vectors in human blood and highlights the usefulness of the blood loop model in predicting patient responses to vectors and testing methods to prolong survival of gene therapy vectors in vivo.
HLA antigens and seronegative rheumatoid arthritis.
Authors: T Bardin, L Legrand, B Naveau, A Marcelli-Barge, N Debeyre, G M Lathrop, J C Poirier, M Schmid, A Ryckewaert, A Dryll
Journal: Annals of the Rheumatic Diseases (1985)

HLA antigens and clinical features in a series of 46 Caucasian patients (40 females, 6 males) and definite repeatedly seronegative rheumatoid arthritis (RA) of more than two years9 duration (mean 11.6 years) were compared with those in 77 seropositive RA patients and 110 controls of the same ethnic and geographic origin. Seronegative RA appeared to be less often erosive than seropositive RA, and seronegative patients had fewer extra-articular features. The frequency of the HLA antigen DR1 was raised in seronegative patients as compared with controls (p = 0.006, relative risk = 3) and with seropositive patients (p less than 0.05). HLA-DR4 was slightly increased in seronegative patients compared with controls (p less than 0.05) but was clearly less so than in seropositive patients (p less than 0.005). Early onset of disease was very significantly associated with HLA-DR1 in seronegative patients (p = 0.007), whereas HLA-DR4 was present more frequently in seropositive patients with onset prior to age 35 (p less than 0.05). No correlation between HLA antigens and intolerance to drugs was found in seronegative patients, whereas in seropositive patients side effects to gold salts were associated with DR3. These results suggest that seropositive and seronegative RA have distinct HLA-DR associations, especially in disease of early onset, in addition to well established clinical differences.
Lysergic acid diethylamide intoxication.
Authors: H. Matthew
Journal: BMJ (1968)

MMICJOULreabsorption either in their patient with primary aldosteronism or in their earlier studies on the effect of aldosterone in normal subjects.2At the present time it is believed, on evidence which is mainly derived from animal experiments, that potassium secretion into the colon is passive and occurs as a result of the negative intraluminal potential created by active absorption of sodium ion.If this view is correct the primary action of aldosterone is likely to be on sodium, as appears to be the case in all other tissues, including the renal tubule,4 in which aldosterone influences electrolyte transport.The fact that Levitan and Ingelfinger,5' using essentially the same
Regulation of Stem Cell Plasticity: Mechanisms and Relevance to Tissue Biology and Cancer
Authors: Robert Strauss, Petra Hamerlik, André Lieber, Jiri Bartek
Journal: Molecular Therapy (2012)

Embryonic stem cells (ESCs) are associated with a high degree of plasticity, which allows them to self-renew and differentiate into every somatic cell. During differentiation, ESCs follow a hierarchically organized pattern towards tissue specificity, which ultimately results in permanent cell cycle arrest and a loss of cellular plasticity. In contrast to their normal somatic counterparts, cancer cells retain elevated levels of plasticity that include switches between epithelial and mesenchymal phenotypes. Transitions between these cell stages have lately been linked to the reacquisition of stem cell features during cellular reprogramming and dedifferentiation in normal and neoplastic cells. In this review, we discuss the key factors and their interplay that is needed to regain a stem cell stage with a particular emphasis put on the impact of cell cycle regulation. Apart from mechanistic insights into the emerging fundamental processes of stem cell plasticity and capacity to transdifferentiate, we also highlight implications of these concepts for tissue biology, tumorigenesis, and cancer therapy. Embryonic stem cells (ESCs) are associated with a high degree of plasticity, which allows them to self-renew and differentiate into every somatic cell. During differentiation, ESCs follow a hierarchically organized pattern towards tissue specificity, which ultimately results in permanent cell cycle arrest and a loss of cellular plasticity. In contrast to their normal somatic counterparts, cancer cells retain elevated levels of plasticity that include switches between epithelial and mesenchymal phenotypes. Transitions between these cell stages have lately been linked to the reacquisition of stem cell features during cellular reprogramming and dedifferentiation in normal and neoplastic cells. In this review, we discuss the key factors and their interplay that is needed to regain a stem cell stage with a particular emphasis put on the impact of cell cycle regulation. Apart from mechanistic insights into the emerging fundamental processes of stem cell plasticity and capacity to transdifferentiate, we also highlight implications of these concepts for tissue biology, tumorigenesis, and cancer therapy.
Abstract 3196: In vivo drug sensitivity testing of CTCs isolated using the FMSA device
Authors: Jean-Nicolas Gallant, Hairong Cheng, Ramdane Harouaka, Siyang Zheng, Wafik S. El-Deiry
Journal: Cancer Research (2012)

Abstract BACKGROUND: Cells disseminated from primary epithelial tumors into peripheral blood, called circulating tumor cells (CTCs), can be monitored to assess metastases and to provide a surrogate marker of treatment response; indeed, the enumeration of fixed CTCs with the Johnson and Johnson Veridex CellSearch System is FDA-approved for assessment of patient prognosis in metastatic breast, prostate, and colorectal cancer. The opportunity to isolate viable CTCs using the Flexible Micro Spring Array (FMSA) device – a novel microfluidic device that enriches CTCs by two physical parameters: size and flexibility – offers the possibility of testing cancer treatments in real time and rapidly providing information back to clinicians regarding the best course of treatment. OBJECTIVES: In this study, we evaluated the possibility of isolating viable CTCs from human blood using the FMSA device, growing these cells in a mouse xenograft model, and determining successful treatments for metastatic disease. METHODS: GFP-labeled HCT-116 cells were spiked into samples of blood from healthy donors to mimic the blood of patients with metastatic disease. This spiked blood was filtered using the FMSA device, and the recovered cells were implanted into the flanks of immunodeficient mice for study. A series of in vivo experiments were carried out to investigate the effect of chemotherapy on the resulting tumors. These tumors were molecularly characterized, compared to tumors derived from non-filtered cells, and analyzed for potential differences resulting from FMSA enrichment. Studies are ongoing to further investigate the use of this model and approach to culture CTCs from patients. RESULTS &amp; CONCLUSIONS: Cancer cells isolated from blood using the FMSA can proliferate when implanted subcutaneously into the flanks of immunodeficient mice – developing into tumors within two weeks. Although they grow at rates that depend on the number of cancer cells found in each mL of blood, these tumors provide a means for testing the effects of chemotherapy on CTCs in vivo. Using this model, treatments targeted towards CTCs could be assessed and provide real-time information to clinicians regarding treatment interventions for patients with metastatic cancer and detectable CTCs. It may also be possible to use this model as the primary mode for CTC culture as the in vivo environment may provide soluble factors, cell-to-cell interactions, and physical parameters that are not easily mimicked by in vitro culture. The approach has potential to help with efforts to develop personalized therapy options for patients with advanced cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3196. doi:1538-7445.AM2012-3196
Geriatrics, Medicine, and Rehabilitation
Authors: Louis Friedfeld
Journal: JAMA (1961)

A geriatric clinic in a general hospital has developed a diagnostic and therapeutic program with rehabilitation goals for the aged. Medical, psychiatric, and psychosocial studies were integrated to determine needs and to provide broad, flexible, centrally coordinated services. Hospital resources were supplemented by other community facilities. This enabled many elderly people to live within the community and to avoid more costly, less satisfactory institutional living. Out of 100 patients re-evaluated after two years, 65 showed improvement in medical, psychiatric, and psychosocial areas, and 12 remained stabilized without further deterioration.
Lymphocytic focus score as a prognostic tool
Authors: Anna P Risselada, Maria de Hair, Aike A Kruize, Johannes W J Bijlsma, Joel A G van Roon
Journal: Annals of the Rheumatic Diseases (2015)

We would like to thank Dr Arnaud et al 1 for their comment on our article discussing the prognostic value of salivary gland assessments in primary Sjogren’s syndrome (pSS).2

One of our findings was that having a lymphocytic focus score (LFS) ≥3 (number of foci/4 mm2) at the time of diagnosis contributes significantly to the risk of lymphoma development during pSS disease course. We agree that the follow-up time after biopsy is important to …