tbuckley/cabot-search huggingface dataset:
Comparison of a Neurothesiometer and Vibration in Measuring Vibration Perception Thresholds and Relationship to Nerve Conduction Studies
Authors: Vera Bril, Jasna Kojic, Mylan Ngo, Kelly Clark
Journal: Diabetes Care (1997)

To compare vibration perception thresholds (VPTs) obtained with two different instruments, a neurothesiometer and a vibratron, and to characterize variability of repeat measures and correlation with sural nerve conduction parameters.A total of 152 patients with diabetic peripheral neuropathy received electrodiagnostic evaluation and quantitative VPT testing with the Vibratron II and the Horwell Neurothesiometer. Of the patients, 42 returned for repeat nerve conduction studies and VPT testing with both types of equipment on three separate occasions.The variability of repeat testing for the vibratron was 34 and 31% in the right and left first toes, respectively. Variability for neurothesiometer was 8 and 6% for the right and left toes. This variability compares with that of sural nerve conduction velocity of 2% and that of sural nerve amplitude of 8% in this series of patients.We conclude that VPT determined with the neurothesiometer is less variable than with the vibratron and more reflective of peripheral nerve function. Our results indicate that the neurothesiometer can be used reliably in clinical research trials.
Death in the Open
Authors: Lewis Thomas
Journal: New England Journal of Medicine (1973)

MOST of the dead animals you see on highways near the cities are dogs, a few cats. Out in the countryside, the forms and coloring of the dead are strange; these are the wild creatures. Seen from a car window, they appear as fragments, evoking memories of woodchucks, badgers, skunks, voles, snakes, sometimes the mysterious wreckage of a deer.It is always a queer shock — part a sudden upwelling of grief, part unaccountable amazement. It is simply astounding to see an animal dead on a highway. The outrage is more than just the location; it is the impropriety of . . .
IgE, IgG4 and IgA specific to Bet v 1‐related food allergens do not predict oral allergy syndrome
Authors: E. E. Guhsl, G. Hofstetter, N. Lengger, W. Hemmer, C. Ebner, R. Fröschl, M. Bublin, C. Lupinek, H. Breiteneder, C. Radauer
Journal: Allergy (2014)

Birch pollen-associated plant food allergy is caused by Bet v 1-specific IgE, but presence of cross-reactive IgE to related allergens does not predict food allergy. The role of other immunoglobulin isotypes in the birch pollen-plant food syndrome has not been investigated in detail.Bet v 1-sensitized birch pollen-allergic patients (n = 35) were diagnosed for food allergy by standardized interviews, skin prick tests, prick-to-prick tests and ImmunoCAP. Concentrations of allergen-specific IgE, IgG1, IgG4 and IgA to seven Bet v 1-related food allergens were determined by ELISA.Bet v 1, Cor a 1, Mal d 1 and Pru p 1 bound IgE from all and IgG4 and IgA from the majority of sera. Immunoglobulins to Gly m 4, Vig r 1 and Api g 1.01 were detected in <65% of the sera. No significant correlation was observed between plant food allergy and increased or reduced levels of IgE, IgG1, IgG4 or IgA specific to most Bet v 1-related allergens. Api g 1-specific IgE was significantly (P = 0.01) elevated in celeriac-allergic compared with celeriac-tolerant patients. Likewise, frequencies of IgE (71% vs 15%; P = 0.01) and IgA (86% vs 38%; P = 0.04) binding to Api g 1.01 were increased.Measurements of allergen-specific immunoglobulins are not suitable for diagnosing Bet v 1-mediated plant food allergy to hazelnut and Rosaceae fruits. In contrast, IgE and IgA to the distantly related allergen Api g 1 correlate with allergy to celeriac.
495 CLINICAL FEATURES AND DYNAMIC PATTERNS DURING CLINICAL COURSE OF ACUTE-ON-CHRONIC HEPATITIS B LIVER FAILURE CAN PREDICT THE PROGNOSIS OF ACHBLF: A RETROSPECTIVE COHORT STUDY
Authors: Y.-B. Zheng, D.-Y. Xie, Y. Yan, L. Peng, Z.-B. Wu, J. Lai, H. Deng, B.-L. Lin, R.-H. Zhu, Y.-T. Chong, Z.-L. Gao
Journal: Journal of Hepatology (2012)
Use of IgM-Hepatitis A Antibody Testing
Authors: David R. Snydman
Journal: JAMA (1981)

An outbreak of hepatitis, type A, affecting 30 employees of a large metropolitan department store was investigated using traditional case findings, a food preference questionnaire, and case-control methods. In addition, the new serological tests for IgM and IgG antibody to hepatitis A virus (anti-HAV) were employed to establish a serological diagnosis of hepatitis A infection, to define the control group, and to identify the index case, an asymptomatic food handler. Twenty-five of 25 cases tested had IgM anti-HAV, whereas none of 73 controls and one of 46 food handlers were IgM anti-HAV positive. This test eliminated three suspect cases that were diagnosed as hepatitis but that had atypical epidemiologic features. Epidemiologic and serological analysis confirmed the association of illness with eating in the employees' cafeteria and eating cold sandwiches.
Role of malonyl-CoA in heart disease and the hypothalamic control of obesity
Authors: C FOLMES, G LOPASCHUK
Journal: Cardiovascular Research (2006)

Obesity is an important contributor to the risk of developing insulin resistance, diabetes, and heart disease. Alterations in tissue levels of malonyl-CoA have the potential to impact on the severity of a number of these disorders. This review will focus on the emerging role of malonyl-CoA as a key "metabolic effector" of both obesity and cardiac fatty acid oxidation. In addition to being a substrate for fatty acid biosynthesis, malonyl-CoA is a potent inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1, a key enzyme involved in mitochondrial fatty acid uptake. A decrease in myocardial malonyl-CoA levels and an increase in CPT1 activity contribute to an increase in cardiac fatty acid oxidation. An increase in malonyl-CoA degradation due to increased malonyl-CoA decarboxylase (MCD) activity may be one mechanism responsible for this decrease in malonyl-CoA. Another mechanism involves the inhibition of acetyl-CoA carboxylase (ACC) synthesis of malonyl-CoA, due to AMP-activated protein kinase (AMPK) phosphorylation of ACC. Recent studies have demonstrated a role of malonyl-CoA in the hypothalamus as a regulator of food intake. Increases in hypothalamic malonyl-CoA and inhibition of CPT1 are associated with a decrease in food intake in mice and rats, while a decrease in hypothalamic malonyl-CoA increases food intake and weight gain. The exact mechanism(s) responsible for these effects of malonyl-CoA are not clear, but have been proposed to be due to an increase in the levels of long chain acyl CoA, which occurs as a result of malonyl-CoA inhibition of CPT1. Both hypothalamic and cardiac studies have demonstrated that control of malonyl-CoA levels has an important impact on obesity and heart disease. Targeting enzymes that control malonyl-CoA levels may be an important therapeutic approach to treating heart disease and obesity.
Thalidomide-dexamethasone compared with melphalan-prednisolone in elderly patients with multiple myeloma
Authors: Heinz Ludwig, Roman Hajek, Elena Tóthová, Johannes Drach, Zdenek Adam, Boris Labar, Miklós Egyed, Ivan Spicka, Heinz Gisslinger, Richard Greil, Ingrid Kuhn, Niklas Zojer, Axel Hinke
Journal: Blood (2008)
Relative serum amyloid A (SAA) values: the influence of SAA1 genotypes and corticosteroid treatment in Japanese patients with rheumatoid arthritis
Authors: T Yamada
Journal: Annals of the Rheumatic Diseases (2001)

<h3>OBJECTIVES</h3> (1) To determine whether serum concentration of serum amyloid A (SAA) protein is influenced by the SAA1 allele in Japanese patients with rheumatoid arthritis (RA) as previously shown in a healthy control group; and (2) to analyse what factors, based on such an allelic bias, influence the relative SAA values of those patients. <h3>METHODS</h3> SAA and C reactive protein (CRP) concentrations together with SAA1 genotypes were determined in 316 Japanese patients with RA. The relative SAA values were evaluated as an SAA/CRP ratio. <h3>RESULTS</h3> Comparison of the three SAA1 homozygote groups showed that the SAA/CRP ratio was highest in the 1.5/1.5 group (mean 9.0, p&lt;0.01<i>v</i> the other two homozygote groups) followed by the 1.3/1.3 group (mean 7.2, NS <i>v</i> the 1.1/1.1 group) and the 1.1/1.1 group (mean 4.0). The SAA/CRP ratio was significantly higher in patients receiving corticosteroids regardless of the presence of allele 1.5. No clear differences in the ratio between patients with or without amyloidosis were found. <h3>CONCLUSION</h3> The SAA1.5 allele and corticosteroid treatment had a positive influence on SAA concentrations in serum. These findings are important when evaluating SAA concentration in inflammatory diseases and when considering the cause or treatment of amyloidosis.
Feasibility of Partial Hepatic Resection under Hypothermia
Authors: William F. Bernhard, James D. McMurrey, George W. Curtis
Journal: New England Journal of Medicine (1955)

THE limiting factor in the successful surgical management of many intra-abdominal pathologic processes is the presence of hepatic involvement. Extirpation of solitary, superficial lesions of the liver is carried out occasionally, but extensive resections are as yet uncommon. Too often, the criterion of inoperability is hepatic involvement per se, rather than the extent of the process within the liver. The functional reserve and regenerative capacity of the liver cells are often disregarded in this decision. This negative attitude has been engendered by the extreme vascularity and friability of hepatic tissue.Efforts to reduce the hazards of hemorrhage in hepatic surgery . . .
446 TIMING AND FREQUENCY OF DEPRESSION DURING HCV-TREATMENT WITH CONTROLLED-RELEASE-IFNA2B (CR2B) VS. PEGYLATED-IFNA2B (PEG2B): RESULTS FROM SELECT-2, A RANDOMIZED-OPEN-LABEL-72-WEEK-COMPARISON IN 116 TREATMENT-NAIVE PATIENTS WITH GENOTYPE-1 HCV
Authors: W.A. Long, Z. Younossi, E. Lawitz, I. Kotsev, D. Takov, K. Tchernev, A. Rigney, R. Ghalib, S. Stoinov, R. Balabanska, P. Mehra, Z. Krastev
Journal: Journal of Hepatology (2011)
Medical Problems of Society
Authors: A. B. Semple
Journal: BMJ (1967)

s Pharmacological Basis of Therapeutics.For anyone who is addicted to Believe it or Not or has fallen under the spell of Whats Where in London, this book will probably prove compulsive.Acapulco gold, Panama or Rangoon red, Yucatan blue, Ketama green, Congo brown, Angola black-the fact that these are names for varieties of marihuana may be useless information, but totally use- less information
Jugular Pulses in AV Block
Authors: ARNOLD L. COLMAN
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 November 1970Jugular Pulses in AV BlockARNOLD L. COLMAN, M.D.ARNOLD L. COLMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-5-859_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In his article "Jugular Venous Pulse in 2:1 Atrioventricular Block" (Ann Intern Med73:277-279, 1970) Dr. Aronow offers a plausible physiological explanation for the appearance of prominentawaves followed by prominentcwaves in the jugular venous pulses of patients with 2:1 atrioventricular block. The diagnostic value of this observation is doubtful, however, since thenormalvenous pulse includes a prominentawave andcwave, relative to thevwave, and characteristically produces graphic tracings essentially similar to Dr. Aronow's (1), although admittedly the clinical appearance of the venous pulse at the bedside might have...References1. COLMAN A: Clinical Examination of the Jugular Venous Pulse. Springfield, Ill., Charles C Thomas, Publisher, 1966 pg. 113 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 450 Sutter St. San Francisco, Calif. 94108 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1970Volume 73, Issue 5Page: 859-859KeywordsHeart rateJugular venous pulse Issue Published: 1 November 1970 PDF DownloadLoading ...
&lt;emph type="ital"&gt;Spring Storm Approaching&lt;/emph&gt;
Authors: Janet M. Torpy
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance
Authors: Jonathan N Flak, Christa M Patterson, Alastair S Garfield, Giuseppe D'Agostino, Paulette B Goforth, Amy K Sutton, Paige A Malec, Jenny-Marie T Wong, Mark Germani, Justin C Jones, Michael Rajala, Leslie Satin, Christopher J Rhodes, David P Olson, Robert T Kennedy, Lora K Heisler, Martin G Myers
Journal: Nature Neuroscience (2014)
Long-term effect of lamivudine treatment in patients with chronic hepatitis B: how long should we continue lamivudine therapy after HBEAG loss or seroconversion?
Authors: S.P. Hong, K.-H. Han, S.H. Ahn, Y.H. Paik, K.S. Lee, C.Y. Chon, Y.M. Moon
Journal: Journal of Hepatology (2001)
Focus on early years will create fairer society and reduce health inequality, Marmot review says
Authors: Z. Kmietowicz
Journal: BMJ (2010)

More public money should be spent on ensuring a high quality of early child development to create a fairer society and reduce health inequalities, an evidence based review has concluded.

Teaching parents the importance of cuddling their babies and talking to young children can help reduce behavioural problems and aid cognitive development, enabling better progress at school, said Michael Marmot, professor of epidemiology and pubic health at University College London, who led the independent review on tackling health inequalities in England over the next 10 years, commissioned by the government. 

Of the six recommendations in his review this is the priority, he said. With better education, people are better able to find their way through modern society, find employment, and have control over their lives, he added.

“The message of our report is that if you can create a …
Case 2-1961
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. Kibbee
Journal: New England Journal of Medicine (1961)

Presentation of Case A fifty-six-year-old woman entered the hospital because of a painful foot. For approximately three months before admission she noticed pain in the medial aspect of the right foot on walking. Persistent swelling of the right foot began about five weeks before entry. The pain gradually became more severe; it was exacerbated by weight bearing and initially was relieved by rest. The patient had trouble with the right ankle in childhood and on one occasion after a fall. For about thirty years before admission there were periodic episodes of pain in the lateral aspect of the left hip . . .
The Influence of Alexithymic Characteristics on the Self-Perception and Facial Expression of a Physiological Stress State
Authors: Petri Näätänen, Arto Ryynänen, Liisa Keltikangas-Järvinen
Journal: Psychotherapy and Psychosomatics (1999)

In spite of the connection of alexithymic characteristics to many stress-related disorders, little is known about the effects of these characteristics on the self-perception of stress, which may have functional value in the regulation of daily behavior. The present study assessed the influence of alexithymic characteristics on the self-perception of stress in relation to the corresponding physiological/expressive responses during and while recovering from a phasic stressor.A median split of the scores on the Toronto Alexithymia Scale was used to divide 32 healthy middle-aged men into two groups, a high alexithymia (HA) and a low alexithymia (LA) group. Both groups participated in a 3-min hand-grip task, followed by a 3-min recovery period. During these periods, subjects' heart rate (HR) and facial electromyographical (EMG) activity on the corrugator supercilii and frontalis lateralis areas were measured and perceptions of exertion, unpleasantness and tension were self-rated. The perceptual style was assessed with the discrepancy scores: standardized scores of the physiological measures were subtracted from the corresponding standardized scores of the perceptions. Thus, positive scores indicated that self-reported perceptions exceeded the corresponding physiological or expressive activity (overestimation) and negative scores indicated the opposite (underestimation).The HA group decreasingly underestimated exertion in relation to HR during the task and increasingly overestimated it during the recovery period. The HA group also overestimated unpleasantness in relation to the corrugator EMG response during the recovery period.High alexithymic characteristics seem to predispose to the delayed self-perception of physiological stress state so that the beginning of this state may remain subjectively unnoticed and the subjective recovery from it prolonged relative to the physical recovery. During this prolonged subjective recovery the feelings of unpleasantness are not facially expressed. The consequences of this style for health-related behavior are discussed.
THE TREATMENT OF STAMMERING
Authors: G. HUDSON MAKUEN
Journal: JAMA (1910)

CLASSIFICATION  In any consideration of the treatment of stammering, it is convenient and desirable to make three classes. In the first class we put all those nervous children who present any abnormalities of speech development; in the second class, those who have begun to show a tendency stammer by an occasional hesitancy of speech, and in the third class, the confirmed stammerers, those who not only stammer but who know that they stammer, and whose natures have been deeply influenced by it. There are three stages of the affection, therefore, the prodromal, the acute, and the chronic. The first stage is generally characterized by the psycho-physical condition called nervousness, and the speech is rapid and blustering. The second stage is like the first, but it presents the added phenomena of speech hesitation and a more or less frequent repetition of certain sounds. The third stage may represent
Studies of the Development and Decay of the Human Frame
Authors: Reginald R. Cooper
Journal: JAMA (1968)

Anyone fortunate enough to do both research and clinical medicine has the unique chance to transmit ideas between these disciplines and thereby advance both. The author, having had this opportunity, herein presents a summary of his studies and thoughts of 40 years. Superb microradiographs and photomicro-angiographs proclaim a meticulous mastery of these techniques, especially as they are applied to normal bone and epiphyseal cartilage and to that altered by experiment or disease. Some chapters on clinical disorders (osteomyelitis, fractures) indicate extensive clinical experience. The author draws frequently upon the writings of others to emphasize certain points. The bibliography is extensive and useful. The author falls short of his avowed purpose of organizing the presentation in a logical sequence. The table of contents forewarns of a prevailing element of disorganization and repetition which at times makes reading difficult. Many figures are an awkward distance from captions which all too often fail
Prostaglandins, the Glucoreceptor, and Diabetes
Authors: R P Robertson, S A Metz
Journal: New England Journal of Medicine (1979)

The "glucoreceptor" hypothesis has evolved in large part from one of the few surviving generalizations about diabetes mellitus. Patients with this disorder do not respond appropriately to glucose signals. For example, those with hyperglycemia during fasting do not have first-phase insulin secretion (the acute insulin response) after an intravenous glucose challenge.1 Suppression of growth hormone2 and glucagon3 by glucose is impaired in diabetics, and taste buds may have a subnormal perception of glucose molecules.4 Hepatic glucose output, normally suppressed by increments in circulating glucose, remains high in diabetics despite the presence of hyperglycemia.5 A failure to respond to glucose signals . . .
Abstract P1-12-08: Quality of Life in Patients with Locally Advanced or Metastatic Breast Cancer Previously Treated with Anthracyclines and Taxanes who Received Eribulin Mesylate or Capecitabine in a Phase III, Open-label, Randomized Study
Authors: Javier Cortes, Ahmad Awada, Christopher Twelves, Louise Yelle, Jantien Wanders, Martin S Olivo, W Robert Simons, Corina E Dutcus, Peter A Kaufman
Journal: Cancer Research (2012)

Abstract Withdrawn by Author. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-12-08.
Healing Into Hell
Authors: Antonio Di Sabatino
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Snorkel, a 5-Iron, and a Pen
Authors: John C. Nelson
Journal: JAMA (1990)

"Never be the first to use a new drug, nor the last to discard an old one." These words, spoken by Louis S. Goodman, my pharmacology professor when I was a sophomore medical student, had real meaning for me some months ago. A pharmaceutical company representative came to my office to describe the merits of a new product. I often meet socially with drug reps and occasionally listen to their formal presentations. The drug in question was one I use frequently in my specialty, but the delivery mechanism was new, and one with which I was not familiar. The rep's presentation was good, the accompanying explanatory material seemed appropriate, and my questions were answered very professionally. He ended his talk with a question: "Will you use our product?" Dr Goodman's remark jumped into my mind, and I good-naturedly quoted it to the salesman. He smiled politely. We bantered back and