tbuckley/cabot-search huggingface dataset:
Hemolytic-Uremic Syndrome in Two Siblings
Authors: Wolfgang W. Hagge, Keith E. Holley, Edmund C. Burke, Gunnar B. Stickler
Journal: New England Journal of Medicine (1967)

RECENT reviews1 , 3 do not mention the hemolytic-uremic syndrome of children in siblings except for the fatal outcome in six-month-old, hyperlipemic monozygotic twins.3 We encountered this syndrome in siblings. One died of uremia after repeated episodes. The other recovered completely after one episode.Case 1. An 8-month-old girl seen in June. 1949. had had fever and dark urine for 2 days. Physical examination showed only fever. Laboratory findings included anemia. increased blood urea. proteinuria and erythrocyturia. A blood smear disclosed anisocytosis poikilocytosis and burr cells. She subsequently had similar episodes and died of azotemia, hypertension and anuria in 1957. Histologic find . . .
Procedure Volume as a Predictor of Surgical Outcomes
Authors: Edward H. Livingston, Jing Cao
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NONCORRELATION OF THYROGLOBUL IN LEVELS WITH 2 AND 10 mCi I-131 SCANS IN THE FOLLOW-UP EVALUATION OF THYROID CANCER PATIENTS
Authors: L Ramanna, A Waxman, N Chapman, M Brachman, D Tanasescu, D Berman, B Catz, G Braunstein
Journal: Clinical Nuclear Medicine (1982)

Ramanna, L; Waxman, A; Chapman, N; Brachman, M; Tanasescu, D; Berman, D; Catz, B; Braunstein, G Author Information
Direct measurement of hepatic blood flow in native and transplanted organs, with accompanying systemic hemodynamics
Authors: William A. Paulsen, Goran B.G. Klintmalm
Journal: Hepatology (1992)

The purpose of this study was to investigate intraoperatively a population of patients with end-stage liver disease before and after liver transplantation with respect to (a) the range of hepatic and systemic hemodynamics and their changes associated with transplantation and (b) the ability to identify native hemodynamic correlates with specific diagnostic groups. Hepatic artery and portal vein blood flows were determined with square-wave electromagnetic flowmetry. Significant differences related to the type of preservation solution used--Euro-Collins or University of Wisconsin--were identified in some hepatic and systemic hemodynamic measurements from the graft livers. Specifically, cardiac output, total liver blood flow and liver weight were significantly increased in the Euro-Collins group compared with the native and University of Wisconsin groups. Hepatic artery flow was significantly greater and portal vein pressure was significantly lower in the University of Wisconsin group than in the native or Euro-Collins group. In general, comparing the graft and native livers, hepatic artery and portal vein blood flow increased significantly after transplantation, as did hepatic oxygen consumption. Portal vein pressures were dramatically reduced, but systemic arterial pressure remained remarkably constant. The percentage of cardiac output going to the liver increased, as did the portal vein percentage of the total liver blood flow. Diagnostic groups could not clearly be associated with characteristic native liver or systemic hemodynamics. Hemodynamics may be associated more with the stage of the disease process than the disease itself.
Tommaso Campailla and the Syphilis Museum in Sicily
Authors: Ismaël Maatouk, Roy Moutran
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Transesophageal two-dimensional echocardiography: Its role in solving clinical problems
Authors: Elma J. Gussenhoven, Meindert A. Taams, Jos R.T.C. Roelandt, Kees M. Ligtvoet, Jacky McGhie, Lex A. van Herwerden, Michael K. Cahalan
Journal: Journal of the American College of Cardiology (1986)
108 EVALUATION OF A NOVEL BIOCERAMIC DRUG DELIVERY SYSTEM FOR TREATING HEPATOCELLULAR CARCINOMA (HCC) IN VIVO
Authors: J. Swet, K. Simo, H. Pacheco, D. Sindram, D. Iannitti, A. El-Ghannam, I. Mckillop
Journal: Journal of Hepatology (2012)
Assurances are sought that policy of personal health budgets will follow evidence
Authors: C. White
Journal: BMJ (2011)

The Department of Health has denied that the government intends to press ahead with personal health budgets in England irrespective of what the final evaluation of the pilot sites—due in October 2012—concludes.

The denial follows health secretary Andrew Lansley’s announcement on 4 October at the Conservative Party conference that people in receipt of NHS continuing healthcare would be the first to have the right to ask for a personal health budget by April 2014.

Around 53 000 people in England receive NHS continuing healthcare—ongoing care outside hospital for complex health and care needs—at any one time, at a cost to the NHS of £2bn (€2.3bn; $3bn) a year.

Mr Lansley said that personal health budgets, which enable holders to purchase services of their choosing directly or through a third party …
DPP-4 Inhibitors
Authors: Dror Dicker
Journal: Diabetes Care (2011)

The first dipeptidyl peptidase 4 (DPP-4) inhibitor sitagliptin was approved in 2006 as treatment for diabetes concurrently with lifestyle changes. A combined product of sitagliptin and glucophage was approved by the U.S. Food and Drug Administration in 2007. The second DPP-4 inhibitor, saxagliptin, was approved in the U.S. It was approved both as monotherapy as well as in combination with metformin, sulfonylurea, or thiazolidinedione. The use of a DPP-4 inhibitor called vildagliptin was approved in Europe and Latin America also as a combination with metformin, sulfonylurea, or thiazolidinedione. Two other DPP-4 inhibitors are also available (linagliptin and alogliptin). In this review, we will elaborate only on the first three drugs (sitagliptin, saxagliptin, and vildagliptin).

The different DPP-4 inhibitors are distinctive in their metabolism (saxagliptin and vildagliptin are metabolized in the liver and sitagliptin is not), their excretion, their recommended dosage, and the daily dosage that is required for effective treatment. They are similar, however, when comparing their efficacy regarding lowering HbA1c levels, safety profile, and patient tolerance.

The influence of DPP-4 inhibitors on the blood levels of HbA1c as monotherapy or in combination with other oral antidiabetes drugs was tested in multiple trials lasting 12–52 weeks. The results of these important trials were reviewed by Davidson (1) and will be summarized here briefly. Treatment with sitagliptin showed an average decrease in HbA1c levels of 0.65% after 12 weeks of treatment, 0.84% after 18 weeks of treatment, 0.85% after 24 weeks of treatment, 1.0% after 30 weeks of treatment, and 0.67% after 52 weeks of treatment. Treatment with saxagliptin showed an average decrease in HbA1c levels of 0.43–1.17%. Treatment with vildagliptin showed an average decrease in HbA1c levels of 1.4% after 24 weeks as monotherapy in a subgroup of patients with no prior oral treatment and …
Enrichment of hepatic progenitor cells from adult mouse liver
Authors: Hisaya Azuma, Tetsuro Hirose, Hideaki Fujii, Shoshiro Oe, Kentaro Yasuchika, Takahisa Fujikawa, Yoshio Yamaoka
Journal: Hepatology (2003)

Hepatic progenitor cells (HPCs) have been characterized in several drug-treated rodent models and in the fetal liver; however, their properties have not been fully clarified in the normal adult liver, presumably because of their relatively small population and the existence of mature hepatocytes. In an attempt to resolve this issue, we developed a new enrichment system for HPCs using their cell aggregate formation properties. Nonparenchymal cells (NPCs) derived from enzymatically digested liver cells in normal adult mouse liver were treated in a hypoxic 2-hour suspension culture under constant shaking. This procedure resulted in cell aggregate formation and almost complete elimination of mature hepatocytes. Cell aggregates were formed only in Ca(2+)-containing medium, suggesting cadherin-dependent cell-cell adhesion. In these cell aggregates, 95% consisted of vascular endothelial cells that expressed VE-cadherin. The remaining 5% consisted of rapidly proliferating, small epithelial cells that expressed alpha-fetoprotein (AFP), E-cadherin, and albumin but not cytokeratin 19 (CK19), alpha-smooth muscle actin, or VE-cadherin. These results are consistent with an immature hepatic cell phenotype. When these immature hepatic cells were cultured with 10(-7) mol/L dexamethasone and 1% dimethyl sulfoxide, the de novo expression of mature hepatocyte markers such as tryptophan-2,3-dioxygenase (TO) was induced concomitantly with the induction of morphologic characteristics such as mitochondria- and peroxisome-rich cytoplasm and bile canaliculi formation. In conclusion, our methodology allows the enrichment of immature hepatic cells from the normal adult mouse. These cells are capable of growth and maturation along the hepatocyte lineage, indicating that these cells are HPCs.
Alveolar Macrophages Have a Protective Antiinflammatory Role during Murine Pneumococcal Pneumonia
Authors: Sylvia Knapp, Jaklien C. Leemans, Sandrine Florquin, Judith Branger, Nico A. Maris, Jennie Pater, Nico van Rooijen, Tom van der Poll
Journal: American Journal of Respiratory and Critical Care Medicine (2003)

Alveolar macrophages (AMs) are considered major effector cells in host defense against respiratory tract infections by virtue of their potent phagocytic properties. In addition, AMs may regulate the host inflammatory response to infection by production of cytokines and by their capacity to phagocytose apoptotic polymorphonuclear cells (PMNs). To elucidate the in vivo contribution of AM to host defense against pneumococcal pneumonia, we depleted mice of AMs via pulmonary application of liposomal dichloromethylene-bisphosphonate (AM- mice) before inoculation with Streptococcus pneumoniae; control mice received saline (AM+sal) or liposomal phosphate-buffered saline (AM+lip) before bacterial inoculation. AM- mice displayed a significantly higher mortality compared with AM+ control mice, whereas bacterial clearance did not differ. Poor outcome of AM- mice was accompanied by a pronounced increase of local proinflammatory cytokine production as well as strongly elevated and prolonged pulmonary PMN accumulation. Closer examination of infiltrating PMN in AM- mice disclosed high proportions of apoptotic and secondary necrotic cells, reflecting the lack of efficient clearance mechanisms in the absence of AMs. Furthermore, caspase-3 staining showed only slightly higher activity in AM- mice, arguing against accelerated apoptosis per se. These data suggest that AMs are indispensable in the host response to pneumococcal pneumonia by means of their capacity to modulate inflammation, possibly via elimination of apoptotic PMNs.
ON THE AETIOLOGY OF PSORIASIS
Authors: P. D. Mier, J. M. Gommans, H. Roelfzema
Journal: British Journal of Dermatology (1980)

Journal Article ON THE AETIOLOGY OF PSORIASIS Get access P. D. Mier, P. D. Mier Department of Dermatology, University of Nijmegen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar J. M. Gommans, J. M. Gommans Department of Dermatology, University of Nijmegen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar H. Roelfzema H. Roelfzema Department of Dermatology, University of Nijmegen, The Netherlands Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 103, Issue 4, 1 October 1980, Pages 457–460, https://doi.org/10.1111/j.1365-2133.1980.tb07272.x Published: 01 October 1980
Renal Aneurysms and IgA Nephropathy
Authors: Emanuela Cecchin
Journal: Annals of Internal Medicine (1995)

Letters15 November 1995Renal Aneurysms and IgA NephropathyEmanuela Cecchin, MD, Sergio De Marchi, MD, and Ettore Bartoli, MDEmanuela Cecchin, MDUniversity of Udine Medical School; Udine, ItalySearch for more papers by this author, Sergio De Marchi, MDUniversity of Udine Medical School; Udine, ItalySearch for more papers by this author, and Ettore Bartoli, MDUniversity of Udine Medical School; Udine, ItalySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-10-199511150-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We describe a patient with previously diagnosed IgA nephropathy presenting with persistent macrohematuria and iron-deficiency anemia, in whom angiography showed multiple bilateral renal aneurysms.In January 1993, a 31-year-old woman was hospitalized because of persistent macrohematuria and moderate iron-deficiency anemia. She did well until 1987, when she experienced two episodes of gross hematuria. A percutaneous renal biopsy specimen showed a moderate focal and segmental mesangial proliferation associated with a discrete increase in the mesangial matrix in 75% of the glomeruli. Tubulointerstitial changes were minimal, and there was no evidence of vasculitis. The immunopathologic pattern was characterized by ...References1. Fleming RJ, Stern LZ. Multiple intraparenchymal renal aneurysms in polyarteritis nodosa. Radiology. 1965; 84:100. Google Scholar2. Hekali P, Kajander H, Stenman S, Somer T. Diagnostic significance of angiographically observed visceral aneurysms with regard to polyarteritis nodosa. Acta Radiol. 1991; 32:143-8. Google Scholar3. Pouwels MJ, Koolen MI, van Liebergen FJ, Assmann KJ. Angiographically demonstrable bilateral renal aneurysms in a patient with diabetic nephropathy. Nephron. 1993; 64:493-5. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Udine Medical School; Udine, Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCombined glomerular deposition of polymeric rat IgA and IgG aggravates renal inflammation 15 November 1995Volume 123, Issue 10Page: 810KeywordsAneurysmsAngiographyArteriesBiopsyIron deficiency anemiaSystemic diseasesTemporal arteritisUreterUrineVasculitis Issue Published: 15 November 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Duration of Immunity After Hepatitis B Vaccination: Efficacy of Low-Dose Booster Vaccine
Authors: MARY M. HOROWITZ
Journal: Annals of Internal Medicine (1988)

Although the efficacy of hepatitis vaccine is well documented, the duration of immunity of healthy adults after vaccination is unknown. We studied 245 hospital employees 3 years after primary vaccination with hepatitis B vaccine to determine the prevalence of immunity indicated by levels of antibody to hepatitis B surface antigen of 10 mIU/mL or greater; and to compare the immunogenicity of low-dose intradermal vaccine with standard-dose intramuscular vaccine in persons found to be seronegative. Thirty-eight percent of employees studied had antibody levels less than 10 mIU/mL. Low levels were associated with smoking, older age, and higher body-mass index. Seventy-eight percent of persons with low antibody levels responded to a single booster vaccine. Two micrograms of intradermal vaccine was as effective as 20 micrograms of intramuscular vaccine in inducing an antibody response; however, intradermal vaccine was associated with more local reactions (42% compared with 17%). Many healthy adults will need periodic boosters of hepatitis B vaccine to maintain production of antibody to hepatitis B surface antigen; low-dose intradermal booster schedules may be feasible.
A Patient with Primary Hyperparathyroidism and an Abnormal Bone Scan
Authors: R J M VAN LEENDERT, J A FLENDRIG
Journal: Clinical Nuclear Medicine (1986)

A patient with primary hyperparathyroidism whose bone scan showed signs of extensive pulmonary and gastric calcifications is described. The patient also had renal insufficiency. A review of the literature and of data of 13 patients with primary hyperparathyroidism who were seen in the Department of Internal Medicine at the University Hospital of Maastricht, led to the conclusion that only in patients with renal insufficiency could ectopic calcifications be expected to occur. Phosphate retention, rather than the hyperphosphaturia that occurs in that particular situation, is cited as the cause.
Androgenic Hormones Modulate Autoantibody Responses and Improve Survival in Murine Lupus
Authors: Jirayr R. Roubinian, Ruben Papoian, Norman Talal
Journal: Journal of Clinical Investigation (1977)

Antibodies to native DNA and to polyadenylic acid (Poly A) occur spontaneously and undergo a regulated switch from IgM to IgG during the course of autoimmune disease in NZB/NZW F1 (B/W) mice. B/W females have higher titers and earlier commitment to 7S antibodies to DNA and Poly A, whereas B/W males bind DNA and Poly A primarily by 19S antibodies. We have performed castration experiments to determine the effects of sex hormones on this switch from IgM to IgG.
Spiking Survanta with Synthetic Surfactant Peptides Improves Oxygenation in Surfactant-deficient Rats
Authors: FRANS J. WALTHER, JOSÉ HERNÁNDEZ-JUVIEL, ROBERTA BRUNI, ALAN J. WARING
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

The hypothesis that the in vivo function of Survanta (Beractant) can be improved by supplementation with synthetic surfactant peptides B and C was tested in a surfactant-deficient rat model. Full length surfactant protein-B (SP-B1–78) (B) and palmitoylated surfactant protein-C (SP-C1–35) (C), and synthetic KL4 peptide were added to Survanta after extraction, creating extracted Survanta (ES) with 1% B, 2% B, and 2% B plus 1% C, or mixed with Survanta without extraction, creating modified Survanta (S) with 2% B, 2% B plus 1% C, and 2% KL4. Adult rats were ventilated with 100% oxygen, tidal volumes (Vt) of 7.5 ml/kg and a rate of 60/min, and were lavaged until the PaO2 dropped below 80 mm Hg, when 100 mg/kg of surfactant was instilled. After 15 to 60 min of ventilation, pressure–volume (P–V) curves were generated in situ. Instillation of ES or S with 2% B plus 1% C led to the greatest increase in oxygenation, closely followed by ES and S with 2% B, and more distantly by S plus 2% KL4. TLC was comparable among the ES and S groups, but greater than that of air-placebo controls. These data suggest that spiking of Survanta with synthetic SP-B and SP-C increased oxygenation more effectively than B or KL4 alone in this surfactant-deficient rat model.
Induction of heparin-binding epidermal growth factor-like growth factor mRNA in rat kidney after acute injury.
Authors: T Homma, M Sakai, H F Cheng, T Yasuda, R J Coffey, R C Harris
Journal: Journal of Clinical Investigation (1995)

Previous studies have suggested that EGF or other members of the EGF family of mitogenic proteins are involved in proliferation of renal tubular epithelial cells occurring during recovery from injury to the kidney. The present studies examined whether expression of mRNA for the recently identified heparin-binding EGF-like growth factor (HB-EGF) is regulated in response to renal injury induced by either ischemia/reperfusion or mercuric chloride. Increased expression of HB-EGF mRNA was demonstrated in the post-ischemic kidney within 45 min of unilateral ischemia/reperfusion in the rat. Induction of HB-EGF mRNA occurred only when ischemia was followed by reperfusion, and was not eliminated by removal of blood cells from the post-ischemic kidney by saline perfusion. In situ hybridization with 35S-labeled antisense riboprobes of HB-EGF indicated that compared with control, there was increased HB-EGF mRNA expression in the 6 h post-ischemic kidney in the inner cortex and outer medulla in a patchy distribution, with the greatest expression in the inner stripe of the outer medulla. Expression occurred primarily in tubular epithelial cells. Recombinant human HB-EGF stimulated [3H]-thymidine incorporation in both primary cultures of rabbit proximal tubule cells and NRK 52E normal rat kidney epithelial cells, with potency similar to that of EGF. Induction of HB-EGF mRNA was observed in tubules freshly isolated from rat renal cortex or outer medulla when the tubules were subjected to reoxygenation after incubation in anoxic conditions. The nephrotoxin, mercuric chloride, also caused induction of HB-EGF mRNA both in vivo and in isolated rat cortical tubules. The anoxia/reoxygenation-induced expression of HB-EGF mRNA in isolated tubules was inhibited by the free radical scavengers, di- and tetra-methylthiourea, indicating involvement of reactive oxygen species. These findings indicate that HB-EGF mRNA is inducible in the kidney in vivo by acute tubular injury and suggest that HB-EGF may act as an autocrine/paracrine growth factor involved in proliferation of tubular epithelial cells and repair of the kidney.
Physicians' Warnings for Unfit Drivers and the Risk of Trauma from Road Crashes
Authors: Donald A. Redelmeier, Christopher J. Yarnell, Deva Thiruchelvam, Robert J. Tibshirani
Journal: New England Journal of Medicine (2012)

Physicians' warnings to patients who are potentially unfit to drive are a medical intervention intended to prevent trauma from motor vehicle crashes. We assessed the association between medical warnings and the risk of subsequent road crashes.