tbuckley/cabot-search huggingface dataset:
Neuroendocrine Tumors of Unknown Primary
Authors: Emily K. Bergsland, Eric K. Nakakura
Journal: JAMA Surgery (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Too little salt in diet can be as bad as too much, study shows
Authors: I. Torjesen
Journal: BMJ (2014)

A lack of salt in the diet can increase the risk of a major cardiovascular event and death, just as consuming too much salt does, research has shown.

Previous studies have suggested a “J shaped” association between sodium intake and cardiovascular disease or death, but many of these studies included participants at high cardiovascular risk who were not representative of the general population. But in the Prospective Urban Rural Epidemiology (PURE) study, published in the New England Journal of Medicine last month,1 researchers examined how urinary sodium and potassium excretion was associated with death and major cardiovascular events in a population group who largely had no history of cardiovascular disease.

The researchers obtained morning fasting urine samples from 101 945 people …
Are ethical principles relative to time and place? A Star Wars perspective on the Alder Hey affair
Authors: K. D Arcus
Journal: BMJ (2002)

find.As my legal friends would put it, "details that could reasonably have been expected to appear in evidential text were absent."Watson: So, heart disease remains an enigma-though the striking rise and fall over the past 50 years is strongly suggestive of a biological cause.No doubt those who smoke or take insufficient exercise or whose cholesterol concentrations are greatly raised may be at "increased risk," but none can be determinant (in the way the putative biological cause clearly must be), which is why the pattern of the disease has changed so dramatically quite independently of them.I can hardly wait to smell once again the aroma of a cooked breakfast with an easy conscience.Holmes: Watson, your wish will be granted, and I will instruct Mrs Hudson accordingly.Meanwhile, given everything we have learnt today-and how fascinating it has been-we should perhaps usefully turn our attention to investigating why your fellow doctors have been persuaded to prescribe cholesterol lowering drugs on so massive a scale. 21 22But that is for another day.
Dextran 70 in prophylaxis of thromboembolic disease after surgery: a clinically oriented randomized double-blind trial.
Authors: A Kline, L E Hughes, H Campbell, A Williams, J Zlosnick, K G Leach
Journal: BMJ (1975)

A randomized double-blind trial of prophylaxis of thromboembolism in surgical patients judged by clinical morbidity has been completed. Altogether 831 patients over 40 years of age who underwent elective surgery of the stomach, biliary system, or colon received either dextran 70 or normal saline before the operation. Thirteen of the 435 patients on saline and three of the 396 on dextran developed pulmonary embolism. Eight of these 16 patients died of pulmonary embolism--seven in the saline group and one in the dextran group. As detected either clinically or by 125I-fibrinogen scanning the incidence of deep vein thrombosis was similar in the two groups. There was no increased incidence of excessive bleeding in patients on dextran though clinical impression suggested that some patients on dextran bled excessively. This trial showed that dextran 70 administered by intravenous drip during operation is effective in preventing pulmonary embolism and, in particular, reducing mortality from this cause. It seems to be as effective as subcutaneous heparin but is easier to administer and places less of a burden on nursing services.
A Self-Processing Ribozyme Cassette: Utility against Human Papillomavirus 11 E6/E7 mRNA and Hepatitis B Virus
Authors: Wei-Hua Pan, Ping Xin, John D Morrey, Gary A Clawson
Journal: Molecular Therapy (2004)

We have been developing a self-processing triple-ribozyme cassette, which consists of two cis-acting hammerhead ribozymes flanking an internal, trans-acting hammerhead ribozyme (ITRz). Here, the single ITRz was replaced by two contiguous ITRz (dITRz), and a short poly(A) tail was designed onto the 3′ end of the liberated dITRz, to produce the "SNIPAA" cassette. Self-processing of the cassette appeared to proceed efficiently in cells: The only region of the cassette identified in cells was the liberated dITRz, with approximately 10–20% of the dITRz found within the nucleus. We tested this reagent against two therapeutically important targets, human papillomavirus 11 E6/E7 mRNA and hepatitis B virus (HBV). Library selection protocols were utilized to define accessible target sites, and ribozymes targeted to these sites were very active in vitro. Pairs of the selected ribozymes were then inserted into the SNIPAA cassette. SNIPAA constructs targeted to the E6/E7 mRNA were tested in cell culture using a cotransfection approach. Significant reductions were produced in E6/E7 target, with 80–90% reductions observed at 5 days following cotransfection. SNIPAA constructs targeted to HBV RNA were tested in vivo in a transgenic mouse model. SNIPAA constructs were packaged in liposomes, which were targeted to hepatocytes using asialofetuin, and administered ip. After 2 weeks, a >80% reduction in viral liver DNA was observed. Immunohistochemical staining for core antigen showed a similar decrease in the number of hepatocytes staining positively, compounded by a concomitant loss of residual staining intensity. These results demonstrate the in vivo utility of the self-processing SNIPAA cassette against HBV.
Notification of tuberculosis: how many cases are never reported?
Authors: J M Grange
Journal: Thorax (1993)

<h3>Abstract</h3> Renal fibrosis is accompanied with the progression of chronic kidney disease (CKD). Despite a number of past and ongoing studies, our understanding of the underlying mechanisms remains elusive. Here we explored the progression of renal fibrosis by using a mouse model, unilateral ureter obstruction (UUO). We found that in the initial stage of the progression where extracellular matrix did not deposit yet, the proximal tubular cells arrested at the G2 of the cell cycle. This G2 arrest was induced prior to activation of both DNA damage checkpoint and Wnt/β-Catenin pathway. Further analyses in vivo and in vitro indicated the cyclin dependent kinase inhibitor p21 is involved in the G2 arrest after the damage. The newly produced monoclonal antibody against p21 revealed that the p21 levels were sharply upregulated in response to the damage during the initial stage, but dropped down toward the later stage. To examine the function of p21 in the progression of renal fibrosis, we constructed the novel <i>p21</i> deficient mice by <i>i</i>-GONAD. Compared with wild-type mice, <i>p21</i> deficient mice showed the exacerbation of the fibrosis. Thus we propose that during the initial stage of the fibrosis following the renal damage, tubular cells arrest in the G2 phase depending on p21, thereby safeguarding the kidney functions.
Percutaneous renal embolisation in renovascular hypertension
Authors: D. Russo, V. E Andreucci, V. Iaccarino, R. Niola, A. D. Canton, G. Conte
Journal: BMJ (1988)

8 malades atteints d'hypertension renovasculaire severe non curable par les traitements classiques ou l'angioplastie sont traites par embolisation percutanee. Les resultats sont bons et durables (jusqu'a 50 mois dans un des cas) mais une surveillance prolongee est necessaire car la recidive d'hypertension est possible
Malignant Lesions Can Mimic Gastric Uptake on FDG PET
Authors: Wichana Chamroonrat, Hongming Zhuang, Mohamed Houseni, Ayse Mavi, Ghassan El-Haddad, Chirdeep Bhutain, Abass Alavi
Journal: Clinical Nuclear Medicine (2005)

Gastric FDG uptake is a common observation on positron emission tomography (PET), which is most frequently caused by a nonmalignant etiology. However, a malignant lesion in the region of the stomach must not be overlooked. A 48-year-old woman with a history of melanoma in the esophagus and status postesophagectomy underwent FDG PET to evaluate for tumor recurrence. The images demonstrated hypermetabolism in the region of the location of the stomach. However, considering that the patient had a history of a stomach pullthrough procedure, we felt that this activity was nongastric and represented tumor recurrence, which was subsequently confirmed by computed tomography scan and histopathologic examination.
Remarks on Our Medical Charities
Authors: S. Gamgee
Journal: BMJ (1877)

I VERY deeply feel the honour you have conferred on confidence you have reposed in me, in electing me your no less conscious of weighty responsibility in endeavouring the first duty of this office, in the delivery of the You cannot have failed to notice that in all parts the subject of medical charities has, during the last few a large and increasing share of public attention.It has treated in leading serials of such diverse political Quarterly and the Westminster Reviews, while many our profession, and social reformers outside its pale, much valuable material to the discussion.They necessity of instituting a thorough investigation into of gratuitous medical relief, with a view to check widely-spread abuse.History shows that most of our medical charities members of our profession.As unpaid officers, profession contribute more than any other class the support of our hospitals and dispensaries, suffer from any administrative abuses which may advocates of the free system are well satisfied of others contend that it is pauperising and demoralising with progressive speed.In this conflict of opinion, our faith to either side, we have a right to examine
A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y
Authors: Leigh D. Plant, Peter N. Bowers, Qianyong Liu, Thomas Morgan, Tingting Zhang, Matthew W. State, Weidong Chen, Rick A. Kittles, Steve A.N. Goldstein
Journal: Journal of Clinical Investigation (2006)

Thousands die each year from sudden infant death syndrome (SIDS). Neither the cause nor basis for varied prevalence in different populations is understood. While 2 cases have been associated with mutations in type Vα, cardiac voltage-gated sodium channels (SCN5A), the “Back to Sleep” campaign has decreased SIDS prevalence, consistent with a role for environmental influences in disease pathogenesis. Here we studied SCN5A in African Americans. Three of 133 SIDS cases were homozygous for the variant S1103Y. Among controls, 120 of 1,056 were carriers of the heterozygous genotype, which was previously associated with increased risk for arrhythmia in adults. This suggests that infants with 2 copies of S1103Y have a 24-fold increased risk for SIDS. Variant Y1103 channels were found to operate normally under baseline conditions in vitro. As risk factors for SIDS include apnea and respiratory acidosis, Y1103 and wild-type channels were subjected to lowered intracellular pH. Only Y1103 channels gained abnormal function, demonstrating late reopenings suppressible by the drug mexiletine. The variant appeared to confer susceptibility to acidosis-induced arrhythmia, a gene-environment interaction. Overall, homozygous and rare heterozygous SCN5A missense variants were found in approximately 5% of cases. If our findings are replicated, prospective genetic testing of SIDS cases and screening with counseling for at-risk families warrant consideration.
Hemoglobin Philly (β35 tyrosine→phenylalanine): studies in the molecular pathology of hemoglobin
Authors: Ronald F. Rieder, Frank A. Oski, J. B. Clegg
Journal: Journal of Clinical Investigation (1969)

An abnormal unstable hemoglobin, hemoglobin Philly, was found in three members of a family, each of whom had evidence of a chronic hemolytic state. The presence of the mutant protein was suggested by the rapid appearance of inclusion bodies upon incubation of erythrocytes with brilliant cresyl blue and by the increased heat precipitability of the hemoglobin. However, no abnormal hemoglobin could be demonstrated by electrophoresis or column chromatography. Sulfhydryl titration of the hemolysates with p-mercuribenzoate indicated that there was an average of four reactive sulfhydryl groups per hemoglobin molecule instead of the usual two. The total number of hemoglobin sulfhydryl groups was normal; six groups were measured when denatured globin was reacted with 5,5'-dithiobis[2-nitrobenzoic acid]. This indicated that the increased sulfhydryl reactivity was due to an increased availability to p-mercuribenzoate of the usually unreactive hemoglobin cysteines at beta112 and alpha104. After treatment for (1/2) hr with 4-5 moles of p-mercuribenzoate per mole of hemoglobin, electrophoresis revealed that 30-35% of the hemoglobin had been dissociated into alpha- and beta-chains. Normal hemolysates revealed negligible splitting after 72 hr of similar treatment. The alpha- and beta-chains of hemoglobin Philly were separated from the unsplit hemoglobin A by carboxymethyl cellulose chromatography. Fingerprint and amino acid analyses revealed that tyrosine beta35 was replaced by phenylalanine. In hemoglobin Philly there is loss of the normal hydrogen bond between the tyrosine hydroxyl group and the carboxyl group of aspartic acid alpha126 at the alpha(1)beta(1) contact. This shifts the equilibrium from hemoglobin tetramers toward monomers, exposing the beta112 and alpha104 cysteines. In the cell, precipitation of the unstable monomers may contribute to erythrocyte destruction.
Endoscopic ultrasound elastography in diagnosing chronic pancreatitis: has the strain ratio found its region of interest?
Authors: Pietro Fusaroli, Mohamad Eloubeidi
Journal: Endoscopy (2013)

Endoscopic ultrasonography (EUS) imaging of chronic pancreatitis was first reported in 1986 [1] [2] and a recent systematic review retrieved 51 articles published in the past decade (January 2001 – January 2010) compared with 13 articles in the previous 20 years (1980 – 2000) [3]. Despite this abundant literature, the role of EUS in the diagnosis of chronic pancreatitis is still far from being well established. Chronic pancreatitis has traditionally been regarded as difficult terrain for EUS because it is difficult to diagnose per se, particularly in its early stages, and also because it induces artifacts that hamper the detection of pancreatic neoplasms. Moreover, changes seen on EUS might be early ones and do not necessarily reflect function; hence, there has always been some debate over EUS findings and their clinical relevance, with the potential for EUS to over-diagnose chronic pancreatitis.
Evaluation of a tarcolimus-eluting coronary stent with nanoporous ceramic coating in treatment of native coronary artery lesions: Phase I and II of the PRESENT study
Authors: Ulrich Gerckens, Lutz Buellesfeld, Dieter Horstkotte, Ralf Mueller, Manfred Staberock, Guido Selbach, Thomas Schmidt, Eberhard Grube
Journal: Journal of the American College of Cardiology (2003)
Improvement of ischemic cholangiopathy in three patients with hereditary hemorrhagic telangiectasia following treatment with bevacizumab
Authors: Paraskevi A. Vlachou, Errol Colak, Alexander Koculym, Anish Kirpalani, Tae Kyoung Kim, Gideon M. Hirschfield, Marie E. Faughnan
Journal: Journal of Hepatology (2013)

The ischemic biliary phenotype of hereditary hemorrhagic telangiectasia (HHT) is rare but distinct, with progressive biliary tree ischemia usually resulting in an irreversible secondary sclerosing cholangiopathy. When clinically severe, liver transplant is often indicated. We report three patients with marked HHT associated biliary disease, in whom prolonged anti-vascular endothelial growth factor therapy (bevacizumab) notably reversed imaging evidence of biliary disease and clinically obviated need for liver transplantation during the first year of follow-up.
Combination therapy with pulsed methylprednisolone in rheumatoid arthritis.
Authors: V Neumann, R Hopkins, J Dixon, A Watkins, H Bird, V Wright
Journal: Annals of the Rheumatic Diseases (1985)

Pulsed methylprednisolone (PMP) has been shown to produce clinical improvement and reduction in the ESR and acute phase protein concentrations in patients with active rheumatoid arthritis and has been advocated for use either as an alternative to slow-acting antirheumatoid drugs (SAARDs) or in conjunction with SAARDs to accelerate the response to treatment. To test these potential roles for PMP 45 patients with active RA were randomly allocated to treatment with PMP alone, PMP + sulphasalazine (SAS - at a maintenance dose of 2.0 g/day), or PMP + D-penicillamine (DPA - at a maintenance dose of 500 mg/day). In each case three 1 g intravenous infusions were given on alternate days during the first week of the trial. Patients were monitored for 24 weeks by standard clinical and laboratory measurements. All three treatment groups showed significant clinical and laboratory improvements at two weeks. With PMP + DPA and PMP + SAS these improvements were sustained and were not significantly different in these two treatment groups. However, in the 9PMP only9 group ESR and CRP rose to pretreatment values by eight weeks. Twelve patients withdrew from the study owing to a relapse of the RA. No serious adverse effects were seen in the 9PMP only9 group. Both combination regimens were well tolerated; adverse effects seen were attributable to either DPA or SAS. We conclude that PMP alone is insufficient for treatment of RA but can be used successfully in combination with either DPA or SAS. A comparison between these results obtained from two previous groups of 15 patients treated with DPA alone and SAS alone (using the same study design) shows that PMP accelerated the response to therapy by at least six weeks.
From Hard Copy to Electronic Publishing: Problems in Accessing the Literature
Authors: Susan Crawford
Journal: JAMA (1979)

Each of the disciplines in the physical, biological, and social sciences has developed monitoring devices that enable orderly access to its intellectual content. These are the massive indexing and abstracting services, among them,Chemical Abstracts, Engineering Index, andMathematical Reviews, without which a discipline would have difficulty in progressing, as science is cumulative and is built on previous work.  This issue ofJAMAis dedicated to theIndex Medicus, which has, for more than 100 years, provided the major access to medical information on a worldwide basis. How was thisIndexconceived, and what is the nature of the man who brought it to fruition? Jeffrey Kunz, MD, Fishbein Fellow of the American Medical Association, traces the development ofIndex Medicusfrom 1876 to the present (p 387).  As with most social institutions, the course of theIndexhas been rough, reflecting the economic and political upheavals of each age.
Personality and Family Profiles of Chronic Insulin-dependentDiabetic Patients Using Portable Insulin Infusion Pump Therapy: A Preliminary Investigation
Authors: Johanna Shapiro, Duncan Wigg, M Arthur Charles, Michael Perley
Journal: Diabetes Care (1984)

Thirty patients were studied before and after introduction of portable insulin infusion pump therapy to determine the psychological and family impact of this new technological intervention. No negative psychological impact or dysfunction appeared to be associated with introduction of the pump. On the contrary, the postpump group reported significantly less depression, significantly less anxiety, and significantly greater family cohesion than the prepump group. Other nonsignificant trends were in a direction indicating improved individual and family psychological status.
Comparing algorithms for automated vessel segmentation in computed tomography scans of the lung: the VESSEL12 study
Authors: Rina D. Rudyanto, Sjoerd Kerkstra, Eva M. van Rikxoort, Catalin Fetita, Pierre-Yves Brillet, Christophe Lefevre, Wenzhe Xue, Xiangjun Zhu, Jianming Liang, İlkay Öksüz, Devrim Ünay, Kamuran Kadipaşaogˇlu, Raúl San José Estépar, James C. Ross, George R. Washko, Juan-Carlos Prieto, Marcela Hernández Hoyos, Maciej Orkisz, Hans Meine, Markus Hüllebrand, Christina Stöcker, Fernando Lopez Mir, Valery Naranjo, Eliseo Villanueva, Marius Staring, Changyan Xiao, Berend C. Stoel, Anna Fabijanska, Erik Smistad, Anne C. Elster, Frank Lindseth, Amir Hossein Foruzan, Ryan Kiros, Karteek Popuri, Dana Cobzas, Daniel Jimenez-Carretero, Andres Santos, Maria J. Ledesma-Carbayo, Michael Helmberger, Martin Urschler, Michael Pienn, Dennis G.H. Bosboom, Arantza Campo, Mathias Prokop, Pim A. de Jong, Carlos Ortiz-de-Solorzano, Arrate Muñoz-Barrutia, Bram van Ginneken
Journal: Medical Image Analysis (2014)
Platinum (IV) Pro‐Drug Conjugated NaYF<sub>4</sub>:Yb<sup>3+</sup>/Er<sup>3+</sup> Nanoparticles for Targeted Drug Delivery and Up‐Conversion Cell Imaging
Authors: Yunlu Dai, Xiaojiao Kang, Dongmei Yang, Xuejiao Li, Xiao Zhang, Chunxia Li, Zhiyao Hou, Ziyong Cheng, Ping'an Ma, Jun Lin
Journal: Advanced Healthcare Materials (2012)

A folic acid targeted anticancer drug delivery system based on Pt (IV) complexes pro-drug conjugated up- conversion NaYF4:Yb3+/Er3+ nanoparticles has been developed. The platinum (IV) complexes as pro-drugs can exhibit anti-cancer activities when the platinum (IV) complexes are reduced to platinum (II) in the intracellular environment. Meanwhile, the drug delivery system can be used as a luminescent probe for up-conversion cell imaging. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The revised IPSS is a powerful tool to evaluate the outcome of MDS patients treated with azacitidine: the GFM experience
Authors: Mathilde Lamarque, Sophie Raynaud, Raphael Itzykson, Sylvain Thepot, Bruno Quesnel, Francois Dreyfus, Odile Beyne Rauzy, Pascal Turlure, Norbert Vey, Christian Recher, Caroline Dartigeas, Laurence Legros, Jacques Delaunay, Sorin Visanica, Aspasia Stamatoullas, Pierre Fenaux, Lionel Adès
Journal: Blood (2012)
980 Inhibition of hepatitis C virus RNA translation with antisense taurocholate conjugated phosphorothioate modified oligodeoxynucleotides (ODN) in cell culture
Authors: M QUASDORFF, M GONZALEZCARMONA, A TAMKE, P HOFFMANN, T LEHMANN, J ENGELS, G KULLAKUBLICK, T SAUERBRUCH, W CASELMANN
Journal: Hepatology (2003)