tbuckley/cabot-search huggingface dataset:
Prognostic significance of pronormoblasts in erythrocyte predominant myelodysplastic patients
Authors: Fermina M. Mazzella, David Smith, Paul Horn, James D. Cotelingam, James T. Rector, M. Atef Shrit, Amadeo Pesce, Harold R. Schumacher
Journal: American Journal of Hematology (2006)

Recent studies of acute erythroleukemias have reaffirmed DiGuglielmo's syndrome (M6a, myeloblast-predominant) and disease (M6b, pronormoblast-predominant). M6c (mixed myeloblast/pronormoblast) has also been described. However, MDS is still defined according to the percentage of myeloblasts (% myeloblasts) without including the pronormoblast count. A 20-year retrospective study was performed to identify cases demonstrating ≥50% erythrocytic component and <30% calculated blasts (FAB exclusion criteria) without underlying cause (96 cases). Pronormoblast and myeloblast counts and other variables were analyzed as possible explanatory variables of the variations in survival. Considered alone, increasing % myeloblasts and/or percentage of pronormoblasts (% pronormoblasts) were significant predictors of decreasing survival. When all variables were considered as a multivariate group, the best fitting statistical model for predicting survival was a function of age, % pronormoblasts, IPSS cytopenias, platelet count, and percentage erythrocytic component. Of these, % pronormoblasts was by far the most significant. Nonappearance of % myeloblasts in this model is indicative of high correlations of this count with other variables. Am. J. Hematol. 81:484–491, 2006. © 2006 Wiley-Liss, Inc.
Secretion of IFN-γ and not IL-2 by anergic human T cells correlates with assembly of an immature immune synapse
Authors: Leo M. Carlin, Kumiko Yanagi, Adrienne Verhoef, Esther N. M. Nolte-'t Hoen, John Yates, Leanne Gardner, Jonathan Lamb, Giovanna Lombardi, Margaret J. Dallman, Daniel M. Davis
Journal: Blood (2005)
Acute Rejection Accelerates Graft Coronary Disease in Transplanted Rabbit Hearts
Authors: Tetsuro Nakagawa, Galina K. Sukhova, Elena Rabkin, Gayle L. Winters, Frederick J. Schoen, Peter Libby
Journal: Circulation (1995)

Background The relation between episodes of acute rejection and the development of graft coronary arteriosclerosis remains controversial. We examined the hypothesis that acute rejection episodes accelerate graft coronary arteriosclerosis lesion formation in rabbit allografts. Methods and Results A control group (n=5) received cyclosporine 5 mg · kg −1 · d −1 for 6 weeks after heterotopic heart transplantation. In a rejection group (n=5), cyclosporine was omitted for 4 days at 1 and 4 weeks after transplantation. We studied cross sections of grafted hearts at 6 weeks and evaluated myocardial rejection grade, incidence, and severity and cell composition of intimal lesions in multiple coronary artery profiles. Episodic withdrawal of cyclosporine augmented myocardial rejection (International Society for Heart and Lung Transplantation grades 0, 0, 0, 0, and 1A in the control group to grades 1A, 1B, 2, 3A, and 3B in the rejection group). Episodes of acute rejection significantly increased the incidence (7.8±2.7% to 49.7±1.9%) and severity (from grade 0.10±0.04 to 0.79±0.24) of intimal thickening in graft coronary arteries. Most intimal lesions consisted of smooth muscle cells and contained various degrees of T-lymphocyte infiltration but sparse macrophages. Conclusions In this experimental model, episodes of acute rejection precipitated by cyclosporine withdrawal accelerated the development of graft vascular lesion formation. Activation of vascular cells and leukocyte recruitment during acute rejection may thus contribute to the pathogenesis of graft arteriosclerosis.
THE SAFETY OF PERCUTANEOUS LEFT ATRIAL APPENDAGE CLOSURE FOR STROKE PREVENTION IN ATRIAL FIBRILLATION (AF) PATIENTS: IS THERE EVIDENCE FOR A LEARNING CURVE?
Authors: David R. Holmes, Saibal Kar, Shephal K. Doshi, Petr Neuzil, Vivek Reddy
Journal: Journal of the American College of Cardiology (2011)
1068 A PROTEOMIC STUDY OF CHOLANGIOCELLULAR CARCINOMA FOR DETECTION OF NOVEL BIOMARKERS IN THE BILE
Authors: J. Padden, D.A. Megger, T. Bracht, S. Tautges, M. Kohl, M. Eisenacher, H.E. Meyer, H.A. Baba, J.F. Schlaak, C. Gerges, B. Sitek
Journal: Journal of Hepatology (2013)
Evaluation of the TiMo12Zr6Fe2 alloy for orthopaedic implants: in vitro biocompatibility study by using primary human fibroblasts and osteoblasts
Authors: L. Trentani, F. Pelillo, F.C. Pavesi, L. Ceciliani, G. Cetta, A. Forlino
Journal: Biomaterials (2002)
Scientists Flock to Hear Cloner Wilmut at the NIH
Authors: Charles Marwick
Journal: JAMA (1997)

EVERY SO often the spotlight focuses on some major scientific advance that raises fears in the popular mind of implications for the future of humanity. The announcement in February that scientists in Scotland had succeeded in cloning a sheep has raised concerns that they are only a short step from doing the same thing in humans. "Scottish Institute Under Fire After Breakthrough in Sheep Reproduction" was a headline in one Scottish newspaper, which proceeded to quote an individual, described as an authority on genetics, charging the sheep cloners with "monstrous conduct." In the following weeks this theme occupied major newspapers and magazines around the world. Phrases such as "good and evil" and "playing God" and considerations of the moral significance of the development filled editorial and opinion pages, not to mention television screens. In the United States, President Clinton banned the funding of research on human cloning and charged the
The Relationship between Serum 25-hydroxyvitamin D levels and In-Stent Restenosis in Patients with Stable Coronary Artery Disease
Authors: Alparslan Kurtul, Mustafa Duran, Mikail Yarlıoğlueş, Muhammed Karadeniz, Gökhan Ergün, Ertan Vuruşkan, Emre Akkaya, Sani Namık Murat
Journal: Journal of the American College of Cardiology (2013)
Erratum: P-selectin primes leukocyte integrin activation during inflammation
Authors: Hai-Bo Wang, Jin-Tao Wang, Lei Zhang, Zhen H Geng, Wei-Li Xu, Tao Xu, Yuqing Huo, Xueliang Zhu, Edward F Plow, Ming Chen, Jian-Guo Geng
Journal: Nature Immunology (2014)
CIP4 Controls CCL19-Driven Cell Steering and Chemotaxis in Chronic Lymphocytic Leukemia
Authors: Gema Malet-Engra, Julien Viaud, Loïc Ysebaert, Manon Farcé, Fanny Lafouresse, Guy Laurent, Frédérique Gaits-Iacovoni, Giorgio Scita, Loïc Dupré
Journal: Cancer Research (2013)

Abstract Solid tumor dissemination relies on the reprogramming of molecular pathways controlling chemotaxis. Whether the motility of nonsolid tumors such as leukemia depends on the deregulated expression of molecules decoding chemotactic signals remains an open question. We identify here the membrane remodeling F-BAR adapter protein Cdc42-interacting protein 4 (CIP4) as a key regulator of chemotaxis in chronic lymphocytic leukemia (CLL). CIP4 is expressed at abnormally high levels in CLL cells, where it is required for CCL19-induced chemotaxis. Upon CCL19 stimulation of CLL cells, CIP4 associates with GTP-bound Cdc42 and is recruited to the rear of the lamellipodium and along microspikes radiating through the lamellipodium. Consistent with its cellular distribution, CIP4 removal impairs both the assembly of the polarized lamellipodium and directional migration along a diffusible CCL19 gradient. Furthermore, CIP4 depletion results in decreased activation of WASP, but increased activation of PAK1 and p38 mitogen-activated protein kinase (MAPK). Notably, p38 MAPK inhibition results in impaired lamellipodium assembly and loss of directional migration. This suggests that CIP4 modulates both the WASP and p38 MAPK pathways to promote lamellipodium assembly and chemotaxis. Overall, our study reveals a critical role of CIP4 in mediating chemotaxis of CLL cells by controlling the dynamics of microspike-containing protrusions and cell steering. Cancer Res; 73(11); 3412–24. ©2013 AACR.
Introduction
Authors: L. Aabakken
Journal: Endoscopy (2004)

The burden of colorectal cancer in Europe is severe and increasing, and there is political as well as some medical impetus in the direction of nationwide screening programs. The specific strategies for screening vary, however, indicating the lack of hard evidence on the best choice. Even more variation is seen in the choice of tactics for implementing the strategy chosen. The challenge of motivating the public to adhere to screening programs is daunting, and different countries choose widely different strategies to accomplish this.
Unilateral Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia and Multiple Carcinoids Treated with Surgical Resection
Authors: Sheeba Irshad, Emma McLean, Sheila Rankin, Sally Barrington, George Santis, James Spicer, Loic Lang-Lazdunski
Journal: Journal of Thoracic Oncology (2010)
Theories of Narcosis
Authors: Donald D. Koblin, Edmond I. Eger
Journal: New England Journal of Medicine (1979)

TWO simple observations limit the possible explanations of how anesthetics act. The first concerns the rate at which anesthesia may be achieved. Anesthetics can induce unconsciousness within seconds, and, similarly, awakening can be rapid after discontinuation of anesthesia. This observation rules out long-term biochemical changes as a basis for narcosis. Thus, the theories that survive suggest physical perturbations or alterations of short-term biochemical events.The second observation concerns the varied nature of anesthetic compounds. Xenon, nitrous oxide, diethyl ether, and halothane all induce general anesthesia. The structural diversity of such compounds suggests that anesthetics do not act at a single . . .
Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents
Authors: Songcang Chen, Christopher L. Grigsby, Christopher S. Law, Xiping Ni, Nada Nekrep, Keith Olsen, Michael H. Humphreys, David G. Gardner
Journal: Journal of Clinical Investigation (2009)

In various mammalian species, including humans, water restriction leads to an acute increase in urinary sodium excretion. This process, known as dehydration natriuresis, helps prevent further accentuation of hypernatremia and the accompanying rise in extracellular tonicity. Serum- and glucocorticoid-inducible kinase (Sgk1), which is expressed in the renal medulla, is regulated by extracellular tonicity. However, the mechanism of its regulation and the physiological role of hypertonicity-induced SGK1 gene expression remain unclear. Here, we identified a tonicity-responsive enhancer (TonE) upstream of the rat Sgk1 transcriptional start site. The transcription factor NFAT5 associated with TonE in a tonicity-dependent fashion in cultured rat renal medullary cells, and selective blockade of NFAT5 activity resulted in suppression of the osmotic induction of the Sgk1 promoter. In vivo, water restriction of rats or mice led to increased urine osmolality, increased Sgk1 expression, increased expression of the type A natriuretic peptide receptor (NPR-A), and dehydration natriuresis. In cultured rat renal medullary cells, siRNA-mediated Sgk1 knockdown blocked the osmotic induction of natriuretic peptide receptor 1 (Npr1) gene expression. Furthermore, Npr1-/- mice were resistant to dehydration natriuresis, which suggests that Sgk1-dependent activation of the NPR-A pathway may contribute to this response. Collectively, these findings define a specific mechanistic pathway for the osmotic regulation of Sgk1 gene expression and suggest that Sgk1 may play an important role in promoting the physiological response of the kidney to elevations in extracellular tonicity.
Surveillance in Florida of Continuous Subcutaneous Insulin Infusion Use in Cohort
Authors: L C Deeb, P E Williams
Journal: Diabetes Care (1986)

Because of concerns about safety and expense associated with continuous subcutaneous insulin infusion (CSII), all people who had used CSII as of July 1982 were identified. Annual follow-up has resulted in data for up to 61 mo. Of the 92 nonpregnant registrees, 31 were less than 20 yr old, 36 were 20-29, and 25 were 30 yr or older. Two deaths occurred in 1780 person-months of pump use. The cumulative proportion on the pump (CPOP) or actuarial CSII continuance proportion was 11%. There was no significant difference between sexes or between ages for men, but despite eliminating pregnant women, those greater than or equal to 30 yr old had a CPOP of 0.22, compared with 0.11 for those less than 30 yr (P = .03). Continuance curves were no different for those beginning CSII with or without complications or for those with or without good glucose control. Those who began at patient request did have better CPOP than those who began at physician request (P = .05). Physician perception of clinical, mechanical, or psychosocial problems while on the pump was not predictor of continuance curves as measured by CPOP. Of the 17 physicians queried at the latest update, 9 physicians have 16 current CSII users; these 9 have only 14% of their patients in the original cohort currently on CSII. This is compared with the 3 physicians who have 34 current users and 60% of their original cohort on CSII. Four physicians no longer use CSII. Devices for CSII cost +131/person-month of use.(ABSTRACT TRUNCATED AT 250 WORDS)
Cancer: science and society and the communication of risk
Authors: K. C Calman
Journal: BMJ (1996)

<h3>Summary points</h3> Epidemiological techniques, and the data generated from cancer registration, are powerful in identifying correlations between diseases and clinical outcomes. They do, however, have limitations in setting public policy In understanding issues surrounding risk assessment, perception is a key aspect of understanding patient and public choice. Information sharing is critical A proposal for clarifying the language of risk has been put forward for discussion and debate
Twice Weekly Tuberculosis Chemotherapy
Authors: Leonard D. Hudson
Journal: JAMA (1973)

One hundred one manifestly unreliable outpatients with active tuberulosis were given isoniazid orally, 14 mg/kg, and streptomycin sulfate intramuscularly, 27 mg/kg, in one dose twice weekly for periods from 3.4 to 22.0 months (mean, 13.0 months) following initial daily hospital treatment of 0 to 12 months (mean, 2.9 months). Outpatient treatment was given by a nurse at a place convenient to each patient. Failure to keep appointments occurred at a rate of 4.5%. One relapse occurred during treatment; 62 patients have completed treatment and have been followed up from 0.3 to 55.3 months (mean, 22.8 months) with no relapses to date. The major problem of antituberculosis treatment today is ensuring that patients take their medication. This study demonstrates that high-dose isoniazid and streptomycin therapy given by a nurse twice weekly is an effective, humane, and inexpensive solution.
Government hit squads to help hospitals make savings on PFI deals
Authors: M. Limb
Journal: BMJ (2012)

Seven NHS trusts in England that have run into problems with their private finance initiative deals are to receive emergency help from expert advisers, health minister Simon Burns has announced.

Burns said the Department of Health was taking action to help trusts identify savings on their PFI contracts and reduce the burden of repayments.

He said, “We want trusts with PFI schemes to get what they pay for, to not pay for things that they don’t need and pay a fair price for work done under PFI contracts.”

From this autumn, the Department of Health will send in finance and legal experts …
Chronic Kidney Disease and Risk for Presenting With Acute Myocardial Infarction Versus Stable Exertional Angina in Adults With Coronary Heart Disease
Authors: Alan S. Go, Nisha Bansal, Malini Chandra, Phenius V. Lathon, Stephen P. Fortmann, Carlos Iribarren, Chi-yuan Hsu, Mark A. Hlatky
Journal: Journal of the American College of Cardiology (2011)
ALLOPURINOL AND DRUG INDUCED ALOPECIA
Authors: G.E. Lovatt
Journal: British Journal of Dermatology (1974)

Journal Article ALLOPURINOL AND DRUG INDUCED ALOPECIA Get access G.E. Lovatt G.E. Lovatt The Wellcome Foundation Ltd, London, NW.1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 91, Issue 1, 1 July 1974, Page 115, https://doi.org/10.1111/j.1365-2133.1974.tb06727.x Published: 01 July 1974
Potential Complications of High-Dose Epinephrine-Reply
Authors: M. Callaham, C. W. Barton, S. Kayser
Journal: JAMA (1991)

<h3>In Reply.</h3> — Fleg raises an interesting point regarding the possibility of decreased catecholamine responsiveness with age. The epinephrine dose used did indeed increase with age, with an<i>r</i>value of .24 (by linear regression,<i>y</i>= 1.28×10<sup>-4</sup>-2.39×10<sup>-3</sup>;<i>P</i>=.001) (Figure). There was a similar relationship between age and creatine kinase-MB level, as well as incidence of myocardial infarction. However, we do not believe that any current data justify a dose based on age, particularly considering how poorly studied the dose-response relationship is, and that similar 200-μg/kg doses have been reported to be effective in children when standard doses were not.<sup>1</sup> Karch addresses a wide variety of concerns; we can comment on several. We excluded cardiac arrests due to drug ingestion, and, otherwise, our population resembled all cardiac arrest populations in that the clinician did not and could not know the exact pathophysiological nature of the arrest. Data
High prevalence of multinodular hepatocellular carcinoma in patients with cirrhosis attributable to multiple risk factors
Authors: Pierangelo Fasani, Angelo Sangiovanni, Cristina De Fazio, Mauro Borzio, Savino Bruno, G. Ronchi, Ersilio Del Ninno, Massimo Colombo
Journal: Hepatology (1999)

To see whether or not there is an association between the cause of cirrhosis and the number of hepatocellular carcinoma (HCC) nodules, we analyzed 178 consecutive patients in whom HCC was detected during a prospective screening by abdominal ultrasound (US). The relevant information was obtained from the database of the screening programs operating at four hospitals in the Milan area. One hundred twenty–nine (72%) patients had a single tumor nodule detected by US and 49 (28%) patients had multinodular disease. Ninety–eight (55%) patients had normal serum values of α–fetoprotein (AFP). Tumor staging with biphasic computed tomography (CT) scan or hepatic arteriography with lipiodol revealed that 101 (57%) patients had single tumor nodules and 77 (43%) patients had more than one HCC nodule. After staging, multinodular HCC was more common in patients with multiple risk factors than in the hepatitis C virus (HCV) carriers (56% vs. 38%, P = .05). Interestingly, single tumors were as common in the 126 patients undergoing 6–month interval screening as in the 52 patients who were studied at yearly intervals. The former patients, however, had more small tumors than the latter ones (91% vs. 74%, P = .04). The 22 patients who were alcohol abusers had normal levels of serum AFP more often than the hepatitis B virus (HBV) or HCV carriers or those with multiple risk factors (86% vs. 57%, P &lt; .04; vs. 47%, P &lt; .002; vs. 52%, P &lt; .006, respectively). We concluded that multinodular HCC was underdetected by real time US; it prevailed among patients with multiple risk factors. In these patients, screening with US exams every 6 months may be inadequate for early detection of liver cancer.
Worse Disease-Free Survival in Never-Smokers with ALK+ Lung Adenocarcinoma
Authors: Ping Yang, Kimary Kulig, Jennifer M. Boland, Michele R. Erickson-Johnson, Andre M. Oliveira, Jason Wampfler, Aminah Jatoi, Claude Deschamps, Randolph Marks, Connie Fortner, Shawn Stoddard, Francis Nichols, Julian Molina, Marie-Christine Aubry, Hui Tang, Eunhee S. Yi
Journal: Journal of Thoracic Oncology (2011)
Long-Term Stabilizing Effect of Angiotensin-Converting Enzyme Inhibition on Plasma Creatinine and on Proteinuria in Normotensive Type II Diabetic Patients
Authors: Mordchai Ravid
Journal: Annals of Internal Medicine (1993)

To evaluate the long-term effect of angiotensin-converting enzyme inhibition on proteinuria and on the rate of decline in kidney function in patients with type II diabetes mellitus and microalbuminuria.Randomized, double-blind, placebo-controlled trial. Each patient was followed for 5 years.Six clinics for diabetes mellitus coordinated by a department of medicine in a university hospital in Israel.Ninety-four normotensive, type II diabetic patients with microalbuminuria and normal renal function.The patients were randomly assigned to receive enalapril, 10 mg per day, or placebo. Any increase in blood pressure was treated with long-acting nifedipine.Albuminuria, blood pressure, serum creatinine, fasting blood glucose, and glycosylated hemoglobin levels, every 3 to 4 months.In the patients treated with enalapril, albuminuria decreased from 143 +/- 64 (mean +/- SD) mg/24 h to 122 +/- 67 mg/24 h during the first year. Thereafter, we observed a slow increase to 140 +/- 134 mg/24 h after 5 years. In the placebo group, albuminuria increased from 123 +/- 58 mg/24 h to 310 +/- 167 mg/24 h after 5 years. (Difference in rate of change in proteinuria [P < 0.05]). Kidney function (expressed as mean reciprocal creatinine) declined by 13% in the placebo group and remained stable (-1%) in the enalapril group (P < 0.05). Control of blood glucose levels remained stable, in both groups, throughout the study. The mean blood pressure was stable in the enalapril group (initial group mean, 99 +/- 2.1 mm Hg; fifth-year mean, 100 +/- 3.2 mm Hg) and increased in the placebo group from an initial mean value of 97 +/- 3.2 mm Hg to 102 +/- 3.4 mm Hg at the end of the study period (P = 0.082).In normotensive patients with diabetes mellitus type II, the institution of angiotensin-converting enzyme inhibition during early stages of diabetic nephropathy results in long-term stabilization of plasma creatinine levels and of the degree of urinary loss of albumin. These effects are probably independent of the antihypertensive action of these agents.
Intrahepatic or Systemic Infusion of Fluorodeoxyuridine in Patients with Liver Metastases from Colorectal Carcinoma
Authors: NANCY KEMENY
Journal: Annals of Internal Medicine (1987)

Objective: To compare the efficacy of direct hepatic arterial chemotherapy with systemic chemotherapy in patients with liver metastases from colorectal carcinoma. Design: Randomized trial with crossover allowed from systemic to intrahepatic therapy if tumor progression occurred on systemic therapy. Setting: Academic medical center, referral-based clinic. Patients: One hundred sixty-two patients with hepatic metastases from colorectal carcinoma agreed to be randomly assigned to treatment groups. At laparotomy, 63 were excluded from the study: 25 had hepatic resection; 33, extrahepatic disease; 1, infection; and 4, no tumor. Intervention: Fourteen-day continuous infusion of fluorodeoxyuridine each month using an Infusaid pump (0.3 and 0.15 mg/kg body weight d in the intrahepatic and systemic arms, respectively). Main Results: Intrahepatic therapy produced a significantly higher complete and partial response rate, 50%, compared with 20% for systemic therapy (p = 0. 001). After tumor progression, 60% of the systemic patients crossed over to intrahepatic therapy; 25% then had a partial response, and 33% a minor response or stabilization of disease on intrahepatic therapy. Toxicity included ulcer disease (17%) and biliary sclerosis (8%) in patients receiving intrahepatic therapy and diarrhea (70%) in patients receiving systemic therapy. Extrahepatic disease occurred in 56% and 37% of the patients in the intrahepatic and systemic groups, respectively (p = 0.092). The median survivals were 17 and 12 months, for the intrahepatic and systemic groups, respectively. Conclusion: When compared with systemic therapy, hepatic arterial chemotherapy significantly increases response rate for hepatic metastases from colorectal carcinoma and appears to be a more effective treatment.