tbuckley/cabot-search huggingface dataset:
EphB–ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells
Authors: Carme Cortina, Sergio Palomo-Ponce, Mar Iglesias, Juan Luis Fernández-Masip, Ana Vivancos, Gavin Whissell, Mireia Humà, Nerea Peiró, Lourdes Gallego, Suzanne Jonkheer, Alice Davy, Josep Lloreta, Elena Sancho, Eduard Batlle
Journal: Nature Genetics (2007)
Use by general practitioners of obstetric beds in a consultant unit: report of first 500 cases.
Authors: K. L. Oldershaw, J. M. Brudenell
Journal: BMJ (1968)

The S.E.sector of London within a radius of 5 miles (8 km.) from Lambeth is served by 10 consultant obstetric units.There are no existing general-practitioner maternity units, and none planned, so that with the hospital confinement rate at 80%' opportunities for the general practitioner interested in obstetrics are limited.As a result of discussions in one of the local maternity liaison committees (see Oldershaw, 1965) a scheme was initiated to allow general practitioners the use of some of the existing consultant obsetric beds.This paper deals with the first 500 deliveries supervised by general practitioners (G.P.s) in the consultant obstetric units of Dulwich and St. Giles Hospitals, now both part of King's College Hospital.The deliveries were consecutive, only abor- tions and those patients who moved away being excluded.General Principles of Scheme (l) Only general practitioners on the obstetric list were invited to participate in the scheme.(2) Only women who at the time of booking had unsuitable home conditions and fulfilled the criteria for a home confine- ment or confinement in a G.P. maternity home, as suggested in the Report on Confidential Enquiries into Maternal Deaths in England and Wales, 1958-1960 (p.47), could be considered for booking by the G.P. However, where an abnormality had occurred in a previous pregnancy, but the risk of recurrence was small, the fact that delivery would take place in a consultant unit was considered an adequate safeguard.Each of these cases was referred to the consultant before booking and his express permission obtained.(3) The consultant obstetrician retained sole responsibility for the patients, the G.P. working under his general direction and consulting freely with him at all times.(4) Each G.P. had an
THE ASSOCIATE INFECTIONS OF SCARLET FEVERS.
Authors: W. J. JAQUES
Journal: JAMA (1899)

The object of this paper is to call attention to the fact that scarlet fever is seldom a single infection, and its successful treatment necessitates a knowledge of all the factors contributing to the abnormal condition. It has not yet been positively demonstrated, at least it is not generally accepted, that the causative agent of scarlet fever is a germ, although there is much evidence to indicate it. Each case seems to come from some other case, and under certain conditions it is known to be highly contagious. It also resembles other diseases which we know are caused by a germ. The difficulty of staining the tubercle bacillus delayed its identification. Some similar characteristic may be preventing the identification of the scarlet fever germ. During the past winter, Dr. J. W. Class<sup>1</sup>, Chicago, called the attention of the medical world to a coccus that he found constantly present in
Tight blood pressure control decreases apoptosis during renal damage
Authors: Karina Soto, Dulcenombre Gómez-Garre, Raquel Largo, Julio Gallego-Delgado, Nuria Tejera, Marina P. Catalán, Alberto Ortiz, Juan José Plaza, Covadonga Alonso, Jesús Egido
Journal: Kidney International (2004)
ACUTE ADMINISTRATION OF VARDENAFIL IMPROVES ARTERIAL STIFFNESS AND WAVE REFLECTIONS
Authors: Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Konstantinos Aznaouridis, Konstantinos Rokkas, Athanasios Aggelis, Katerina Baou, Athanasios Askitis
Journal: Journal of the American College of Cardiology (2010)
Abstract LB-55: Histone deacetylase inhibitor causes DNA damage and apoptosis by downregulation of repair enzymes in cancer but not normal cells: Basis of resistance of normal cells to HDACi
Authors: Juhee Lee, Megan L. Choy, Lang Ngo, Steven Foster, Weisheng Xu, John H. Petrini, Paul A. Marks
Journal: Cancer Research (2010)

Abstract Histone deacetylase inhibitors (HDACi) developed as anti-cancer agents have a high degree of selectivity for killing cancer cells. HDACi induce acetylation of histones and many non-histone proteins, affecting gene expression, cell cycle progression, cell migration and cell death. The mechanism of the tumor selective action of HDACi is unclear. Here we show that the HDACi, SAHA (Suberoylanilide hydroxamic acid, vorinostat), induces DNA DSB (double strand break) in normal (HFS) and cancer (LNCaP, A549) cells, but normal cells in contrast to cancer cells repair the DSB despite continued culture with SAHA. In transformed cells, H2AX levels increased with continued culture with SAHA, while in normal cells, this marker of DNA DSB tended to decrease with time. To define the capacity of normal and transformed cells for repair of SAHA induced DNA DSB, cells were cultured for 24hr with SAHA, washed and continued culture without HDACi. In normal cells, the H2AX was undetectable by 2hr (presumably reflecting repair of DNA DSB), while persisting in transformed for duration of culture (presumably reflecting failure to repair DNA DSB) with consequent transformed cell death. Further, we found that SAHA suppressed DNA DSB repair proteins, e.g., RAD50, MRE11, Tip60 and PP2A, in cancer (LNCaP, A549) but not in normal cells (HFS). These findings indicate that the HDACi induces DNA damage in cancer and normal cells, but normal cells have the capacity to repair the DNA DSB, while cancer cells do not owing in part at least to suppression of DNA DSB repair proteins. This selective action of SAHA in inducing transformed cell death points to potential effective therapeutic strategies for combination therapy with HDACi with agents that suppress DNA damage repair proteins. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-55.
Criss-Cross Atrioventricular Relationships Producing Paradoxical Atrioventricular Concordance or Discordance
Authors: ROBERT H. ANDERSON, ELLIOT A. SHINEBOURNE, LEON M. GERLIS
Journal: Circulation (1974)

Two cases are described in which the systemic and pulmonary blood streams cross at atrioventricular level. One was examined pathologically, the other was diagnosed at cardiac catheterization by angiography. Both possessed situs solitus, but in one heart the right atrium was connected to a morphologic right ventricle on the left, whereas in the other it was connected to a left-sided morphologic left ventricle. In both cases transposition of the great arteries was present. The cases have been interpreted as representing rotation of embryonic d- and l-bulboventricular loops following septation. In attempting to describe these heart difficulties in terminology were encountered which were partially overcome by combining the concepts of concordant and discordant atrioventricular relationships with those of transposition and malposition. However, to give an accurate interpretation of the hearts, it proved necessary to include a term indicating rotation of the bulboventricular loop following septation. Thus the hearts were described as situs solitus, discordant (d-rotated) loop with d-transposition, and situs solitus, concordant (l-rotated) loop with l-transposition.
The Importance of Healing Skills in the Medical Home Concept
Authors: Edward J. Volpintesta
Journal: Annals of Internal Medicine (2009)

Letters3 March 2009The Importance of Healing Skills in the Medical Home ConceptEdward J. Volpintesta, MDEdward J. Volpintesta, MDFrom Bethel, CT 06810.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-150-5-200903030-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Many would readily agree with the findings of Churchill and Schenck (1), particularly those clinicians who routinely apply the relational (healing) skills described. But, for practicing physicians, the skills they mentioned require time—and a frame of mind unhindered by the need to see a disproportionate number of patients. Sadly, for many primary care doctors in particular, insurers' low remuneration rates and excessive administrative obligations have polluted the atmosphere for healing skills to survive. Keeping up with the science of medicine is difficult enough, but when the burden of administrative duties is added to the strain of financial ...Reference1. Churchill LR, Schenck D. Healing skills for medical practice. Ann Intern Med. 2008;149:720-4. [PMID: 19017590] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Bethel, CT 06810.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHealing Skills for Medical Practice Larry R. Churchill and David Schenck The Importance of Healing Skills in the Medical Home Concept William E. Cayley Metrics 3 March 2009Volume 150, Issue 5Page: 360KeywordsConflicts of interestDrugsImaging techniquesNursesPatientsPerceptionResidency ePublished: 3 March 2009 Issue Published: 3 March 2009 CopyrightCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
The Hunterian Lectures on Infantile Syphilis: Delivered at the Royal College of Surgeons of England
Authors: J. A. Coutts
Journal: BMJ (1896)

INFANT]LE SYPHILIS.[TDz JOURNA 1025 part of the interlocutor the subject's mental calm remains undisturbed.Muscular Tremors and Inco-ordination.-In a large proportion of cases comprised in this category tremor is a very notable feature, and is usually limited to the tongue, lips, and musdles of the lower facial group; occasionally, but much less frequently, do we find a fine tremor of the hands when the airms are extended horizonitally.The tremor of the oral musculature, especially elicited during voluntary movements as of speech or ingestion of food, or during emotional states, would appear to be due to implication of the cortical mechanism of speech, like the corresponding alcoholic tremor of the hands after a night's debauch.We must distinctly sever it from the further symptom of ataxia, which also in certain of these subjects involves the muscles of the same regions, as indicated by the contortions and grimace presented by them in efforts of protruding the tongue, or of whistling, etc.As i1 shall indicate later, the ataxia thus elicited upon voluntary stimulation of the speech centre is almost certainly due to the implication of the muscular sense fibres of the muscles of articulation, which probably find their termini in this cortical region.Occasionally the ataxy alone presents itself; at times it is associated with much tremor.It may be noted here that reference to the tables aecompanying this article indicates tremor and twitching of the brow -inuscles in six cases.I have emphasised this fact in my work on Mental Diseases, and have long been accustomed to regard the uneasy furrowing and twitching movements of the muscles of the brow as specially characteristic of chronic alcoholism, and as indicating when seen the alcoholic factor in general paralysis also.24
The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants
Authors: Klaas P.J.M. van Gisbergen, Paul L. Klarenbeek, Natasja A.M. Kragten, Peter-Paul A. Unger, Marieke B.B. Nieuwenhuis, Felix M. Wensveen, Anja ten Brinke, Paul P. Tak, Eric Eldering, Martijn A. Nolte, Rene A.W. van Lier
Journal: Immunity (2011)
Chronic Fatigue Syndrome and Neurally Mediated Hypotension-Reply
Authors: Hugh Calkins, Jean Kan, Peter C. Rowe
Journal: JAMA (1996)

<h3>In Reply.</h3> —Dr Beard points to the absence of data to support the common clinical practice of high sodium intake for those with NMH. While he is correct, the same can be said for claims that a low sodium intake is appropriate for everyone. Have any of the large hypertension prevention studies examined fatigue as an adverse outcome of a low sodium diet? Even if mean blood pressure could be lowered by 2.2 mm Hg after a reduction in sodium intake of 2300 mg/d, as predicted by the Intersalt study,<sup>1</sup>we would need to know whether individuals felt better or worse as a result of the dietary change. We would predict that those with an increased susceptibility to NMH would fare worse on the recommended low-sodium diets. Dr Baschetti raises the interesting hypothesis that licorice might be more effective than fludrocortisone for patients with CFS. Until results of a
Fibrin subunits in venous and arterial thromboembolism
Authors: P. J. GAFFNEY, M. BRASHER, K. LORD, C. J. L. STRACHAN, A. R. WILKINSON, V. V. KAKKAR, M. F. SCULLY
Journal: Cardiovascular Research (1976)

The subunit fibrin composition of thrombi of both venous and arterial origin was examined by sodium dodecyl sulphate gel electrophoresis. The thrombi were recovered by surgical intervention and all had the same fibrin subunit composition. The alpha chains were cross-linked as alpha-chain polymers alpha (p), the gamma chains as gamma-chain dimers (gamma-gamma) while the beta chains were not crosslinked; a further subunit of molecular weight 33 000 was shown to be present in all the fibrins examined and was a degradation fragment of the beta or gamma chains. This data suggests that the crosslinked alpha chains are rate limiting to the lysis of thrombi in vivo. The digestion of pulmonary emboli by plasmin yielded soluble degradation products which were identified as D dimer and E, the latter fragments being the major products obtained by the lysis of in-vitro made plasma clots. The similarity of the composition and lysis of thrombus fibrin to that formed in vitro augurs well for the justification of in-vitro research on mechanisms in thrombolysis.
Physical training does not increase allergic inflammation in asthmatic children
Authors: A. Moreira, L. Delgado, T. Haahtela, J. Fonseca, P. Moreira, C. Lopes, J. Mota, P. Santos, P. Rytilä, M. G. Castel-Branco
Journal: European Respiratory Journal (2008)

The effects of a 3-month physical training programme on airway inflammation and clinical outcomes were studied in school-aged children with asthma. Subjects with persistent allergic asthma (aged 12.7±3.4 yrs; n = 34) were randomly allocated into training and control groups. Exercise consisted of twice-weekly 50-min sessions for 12 weeks. Inflammation was assessed by levels of exhaled nitric oxide, blood eosinophils, eosinophil cationic protein, C-reactive protein, and total and mite-specific immunoglobulin (Ig)E. Lung volumes and bronchial responsiveness to methacholine were determined. The Paediatric Asthma Quality of Life Questionnaire and Paediatric Asthma Caregiver's Quality of Life Questionnaire were used to evaluate activity restrictions, symptoms and emotional stress. The efficacy of the training was assessed by accelerometry. Following the programme, the exercise group spent twice as much time as the controls undertaking moderate-to-vigorous activities. No differences in changes were seen between groups for asthma outcomes. However, total IgE decreased more in the exercise group, as did mite-specific IgE. Training did not increase inflammation in children with persistent asthma, and may have decreased both total and allergen-specific immunoglobulin E levels. It is concluded that there is no reason to discourage asthmatic children with controlled disease to exercise.
Implantable defibrillators: Antiarrhythmic therapy of choice in high risk patients with dilated cardiomyopathy
Authors: Patrick J. Tchou, Anita C. Krebs, Kathi Axtell, Jasbir Sra, Mohammad Jazayeri, Paul Troup, Masood Akhtar
Journal: Journal of the American College of Cardiology (1991)
Does Anesthesia Contribute to Operative Mortality?
Authors: Igor Kissin
Journal: JAMA (1989)

<h3>To the Editor.—</h3> Mortality outcome data from a single anesthesia practice involving multiple surgical procedures are interesting and important. However, one conclusion of Cohen et al<sup>1</sup>is that the patient's physical status and surgical risk factors are much more important in determining 7-day mortality than are anesthesia factors (number of anesthetic drugs administered, anesthetic technique, duration of anesthesia, and experience of the anesthesiologist). Some of the data do not support this conclusion. First, comparing the relative odds of mortality in nonmajor surgical cases with American Society of Anesthesiologists physical status scores of 1 through 3 (Table 3 in the article by Cohen et al), anesthesia-related factors are not less important in predicting mortality than are the patient's physical status or surgical factors. The authors do not report anesthetic technique—related relative odds of dying with the lowest (spinal anesthesia) and highest (narcotic alone or narcotic-with-inhalational anesthetic) odds. When we computed
Industrial Pollution
Authors: Arthur L. Frank
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Government offers reassurance about funds for proposed research centre
Authors: Geoff Watts
Journal: BMJ (2008)

A government response to the House of Commons’ Innovation, Universities, Science, and Skills Committee has attempted to allay doubts about the finances of the proposed UK Centre for Medical Research and Innovation. A government decision that the committee had originally viewed as irrational, if not calculated to withhold money from the project, turns out to have been a manoeuvre necessitated by accounting systems at the Treasury.

The issue was raised by the committee in its January report on the progress of the new research centre, due to be located in central London next to the British Library ( BMJ 2008;336:179; doi: 10.1136/bmj.39468.733912.DB). The committee had expressed several concerns …
Dialysance of Molecules of Different Size in Reused Kiil, Ab-Gambro, and Rhone-Poulenc Dialysers
Authors: P. Kramer, D. Matthaei, J. G. Go, H. J. Tonnis, F. Scheler
Journal: BMJ (1972)

Dialysances of urea, creatinine, ethylenediamine tetraacetic acid, and ouabain were determined in three different flat-bed dialysers during three successive uses on 15 patients. There were no untoward reactions. A significant decrease in dialysing efficiency was observed only with the Ab-Gambro dialyser, in which the dialysance of the small molecules decreased more than that of the large. This is thought to result from blood deposits on the membrane surface inhibiting exchange.
The Safety and Efficacy of Infliximab in Moderate to Severe Chronic Obstructive Pulmonary Disease
Authors: Stephen I. Rennard, Charles Fogarty, Steven Kelsen, William Long, Joe Ramsdell, James Allison, Donald Mahler, Constantine Saadeh, Thomas Siler, Phillip Snell, Phillip Korenblat, William Smith, Mitchell Kaye, Michael Mandel, Charles Andrews, Rachakonda Prabhu, James F. Donohue, Rosemary Watt, Kim Hung Lo, Rozsa Schlenker-Herceg, Elliot S. Barnathan, John Murray
Journal: American Journal of Respiratory and Critical Care Medicine (2007)

Chronic obstructive pulmonary disease (COPD) is a progressive, smoking-related, inflammatory lung disease in which tumor necrosis factor-alpha is overexpressed and has been suggested to play a pathogenic role.To determine if infliximab, an anti-TNF-alpha antibody, results in clinical benefit and has an acceptable safety profile in patients with moderate to severe COPD.In a multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-finding study, subjects with moderate to severe COPD received infliximab (3 mg/kg [n = 78] or 5 mg/kg [n = 79]) or placebo (n = 77) at Weeks 0, 2, 6, 12, 18, and 24. Efficacy, health status, and safety were assessed through Week 44.Infliximab was generally well tolerated, but showed no treatment benefit as measured by the primary endpoint, Chronic Respiratory Questionnaire total score. Similarly, there was no change in secondary measures, including prebronchodilator FEV(1), 6-min walk distance, SF-36 physical score, transition dyspnea index, or moderate-to-severe COPD exacerbations. Post hoc analysis revealed that subjects who were younger or cachectic showed improvement in the 6-min walk distance. Malignancies were diagnosed during the study in 9 of 157 infliximab-treated subjects versus 1 of 77 placebo-treated subjects. No opportunistic infections were observed, and there were no differences in the occurrence of antibiotic-requiring infections, although the incidence of pneumonia was higher in infliximab-treated subjects. No infection-related mortality was observed. Higher proportions of infliximab-treated subjects discontinued the study agent due to adverse events (20-27%) than did placebo-treated subjects (9%).Subjects with moderate to severe COPD did not benefit from treatment with infliximab. Although not statistically significant, more cases of cancer and pneumonia were observed in the infliximab-treated subjects. The impact of infliximab on malignancy risk in patients with COPD needs to be further elucidated.
Prespecified Subgroup Analyses in WJOG4407G Trial, a Randomized Phase III Trial of MFOLFOX6 Plus Bevacizumab Versus Folfiri Plus Bevacizumab in First-Line Treatment for Metastatic Colorectal Cancer
Authors: Tamagawa Hiroshi, Yamazaki Kentaro, Suyama Koichi, Okabe Michio, Suzuki Kazuya, Seki Nobuhiko, Kawakami Kentaro, Sato Mikio, Takahashi Yasuo, Hirashima Tomonori, Ebi Masahide, Taku Keisei, Otsuji Toshio, Tamura Fumio, Shinozaki Eiji, Nakashima Koji, Yamaguchi Kensei, Ando Masahiko, Morita Satoshi, Boku Narikazu, Hyodo Ichinosuke
Journal: Annals of Oncology (2014)
Oxidative stress, F2-isoprostanes and endothelial dysfunction in hypercholesterolemia
Authors: C Palombo
Journal: Cardiovascular Research (1999)

attenuated by pretreatment with L-arginine or the NO issue.donor NOR-3.These observations suggest a tonic vasoconstrictor activity dynamically opposed by NO, with the net vasomotor effect resulting from the balance of the two