tbuckley/cabot-search huggingface dataset:
Multiple tissue kallikrein mRNA and protein expression in normal skin and skin diseases
Authors: N. Komatsu, K. Saijoh, T. Toyama, R. Ohka, N. Otsuki, G. Hussack, K. Takehara, E.P. Diamandis
Journal: British Journal of Dermatology (2005)

Human tissue kallikreins are a gene family (KLK1-KLK15) encoding for 15 secretory serine proteases (hK1-hK15). Two tissue kallikrein proteins, hK5 and hK7, were previously found in the stratum corneum (SC), stratum granulosum (SG) and appendages. hK8 was also shown to be secreted via lamellar granules and numerous KLK mRNAs were previously identified. KLKs are believed to be responsible for desquamation of corneocytes and sebum, sweat and hair maturation.To demonstrate immunohistochemically the expression of hK6, hK8 and hK13 in normal skin tissue and to show an increased cell number expressing kallikrein mRNAs and proteins in psoriasis vulgaris (PV) and atopic dermatitis (AD).Samples of normal, PV and AD skin were obtained. hK6-, hK8- and hK13-specific antibodies were produced and used for immunohistochemical analysis. Multiple KLK mRNAs were synthesized and used for in situ hybridization study.Three other hKs, namely hK6, hK8 and hK13, were immunohistochemically identified as new skin serine proteases in the whole SC, SG, sebaceous glands, eccrine sweat glands, hair follicles and nerves. We also demonstrated an increased number of cells expressing KLK mRNAs and hKs in PV and AD. In PV, KLK mRNAs/hKs were predominantly expressed in the upper epidermis. In AD, hK distribution was rather diffuse and expanded into the lower epidermis.The colocalization of various hKs seems to be essential for the regulation of serine protease activity in skin and for steady desquamation and skin barrier function. Moreover, the increased number of cells expressing multiple KLK mRNA and hK in PV and AD could be a clue to elucidate their pathogenesis.
Effects of Cardiac Resynchronization Therapy With or Without a Defibrillator on Survival and Hospitalizations in Patients With New York Heart Association Class IV Heart Failure
Authors: JoAnn Lindenfeld, Arthur M. Feldman, Leslie Saxon, John Boehmer, Peter Carson, Jalal K. Ghali, Inder Anand, Steve Singh, Jonathan S. Steinberg, Brian Jaski, Teresa DeMarco, David Mann, Patrick Yong, Elizabeth Galle, Fred Ecklund, Michael Bristow
Journal: Circulation (2006)

Cardiac resynchronization therapy (CRT) alone or combined with an implantable defibrillator (CRT-D) has been shown to improve exercise capacity and quality of life and to reduce heart failure (HF) hospitalizations and mortality in patients with New York Heart Association (NYHA) class III and IV HF. There is concern that the device procedure may destabilize these very ill class IV patients. We sought to examine the outcomes of NYHA class IV patients enrolled in the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) trial to assess the potential benefits of CRT and CRT-D.The COMPANION trial randomized 1520 patients with NYHA class III and IV HF to optimal medical therapy, CRT, or CRT-D. In the class IV patients (n=217), the primary end point of time to death or hospitalization for any cause was significantly improved by both CRT (hazard ratio [HR], 0.64; 95% CI, 0.43 to 0.94; P=0.02) and CRT-D (HR, 0.62; 95% CI, 0.42 to 0.90; P=0.01). Time to all-cause death and HF hospitalization was also significantly improved in both CRT (HR, 0.57; 95% CI, 0.37 to 0.87; P=0.01) and CRT-D (HR, 0.49; 95% CI, 0.32 to 0.75; P=0.001) Time to all-cause death trended to an improvement in both CRT (HR, 0.67; 95% CI, 0.41 to 1.10; P=0.11) and CRT-D (HR, 0.63; 95% CI, 0.39 to 1.03; P=0.06). Time to sudden death appeared to be significantly reduced in the CRT-D group (HR, 0.27; 95% CI, 0.08 to 0.90; P=0.03). There was a nonsignificant reduction in time to HF deaths for both CRT (HR, 0.68; 95% CI, 0.34 to 1.37; P=0.28) and CRT-D (HR, 0.79; 95% CI, 0.41 to 1.52; P=0.48).CRT and CRT-D significantly improve time to all-cause mortality and hospitalizations in NYHA class IV patients, with a trend for improved mortality. These devices should be considered in ambulatory NYHA class IV HF patients similar to those enrolled in COMPANION.
Oncogenic Role of KIAA0101 Interacting with Proliferating Cell Nuclear Antigen in Pancreatic Cancer
Authors: Masayo Hosokawa, Akio Takehara, Koichi Matsuda, Hidetoshi Eguchi, Hiroaki Ohigashi, Osamu Ishikawa, Yasuhisa Shinomura, Kohzoh Imai, Yusuke Nakamura, Hidewaki Nakagawa
Journal: Cancer Research (2007)

Abstract To isolate novel diagnostic markers and therapeutic targets for pancreatic cancer, we earlier did expression profile analysis of pancreatic cancer cells using a genome-wide cDNA microarray combined with microdissection. Among dozens of trans-activated genes in pancreatic cancer cells, this study focused on KIAA0101 whose overexpression in pancreatic cancer cells was validated by immunohistochemical analysis. KIAA0101 was previously identified as p15PAF [proliferating cell nuclear antigen (PCNA)–associated factor] to bind with PCNA; however, its function remains unknown. To investigate for the biological significance of KIAA0101 overexpression in cancer cells, we knocked down KIAA0101 by small interfering RNA (siRNA) in pancreatic cancer cells and found that the reduced expression by siRNA caused drastic attenuation of their proliferation as well as significant decrease in DNA replication rate. Concordantly, exogenous overexpression of KIAA0101 enhanced cancer cell growth, and NIH3T3 derivative cells expressing KIAA0101 revealed in vivo tumor formation, implying its growth-promoting and oncogenic property. We also showed that the expression of KIAA0101 was regulated tightly by the p53-p21 pathway. To consider the KIAA0101/PCNA interaction as a therapeutic target, we designed the cell-permeable 20-amino-acid dominant-negative peptide and found that it could effectively inhibit the KIAA0101/PCNA interaction and resulted in the significant growth suppression of cancer cells. Our results clearly implicated that suppression of the KIAA0101 and PCNA oncogenic activity, or the inhibition of KIAA0101/PCNA interaction, is likely to be a promising strategy to develop novel cancer therapeutic drugs. [Cancer Res 2007;67(6)2568–76]
Organ- and treatment-specific local response rates to systemic and local treatment modalities in stage IV melanoma
Authors: E. Richtig, R. Ludwig, H. Kerl, J. Smolle
Journal: British Journal of Dermatology (2005)

Journal Article Organ‐ and treatment‐specific local response rates to systemic and local treatment modalities in stage IV melanoma Get access E. Richtig, E. Richtig Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, 8036 Graz, Austria Erika Richtig. E‐mail: erika.richtig@meduni‐graz.at Search for other works by this author on: Oxford Academic Google Scholar R. Ludwig, R. Ludwig Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, 8036 Graz, Austria Search for other works by this author on: Oxford Academic Google Scholar H. Kerl, H. Kerl Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, 8036 Graz, Austria Search for other works by this author on: Oxford Academic Google Scholar J. Smolle J. Smolle Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, 8036 Graz, Austria Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 153, Issue 5, 1 November 2005, Pages 925–931, https://doi.org/10.1111/j.1365-2133.2005.06796.x Published: 01 November 2005 Article history Accepted: 04 April 2005 Published: 01 November 2005
Should We Worry about Hospitals' High Administrative Costs?
Authors: Stuart H. Altman, David Shactman
Journal: New England Journal of Medicine (1997)

In a health care world of negotiated budgets and cost-based reimbursement, it was important for those who paid the bills to focus on the individual cost items that were presented for reimbursement. This is the type of world that existed when Medicare was established in 1965, and it exists today in most of the government-administered systems of Europe and Canada. When Medicare was being implemented, the pundits of the day argued that only by paying “true costs” could the government prevent unnecessary profits and control total Medicare spending. How wrong they were!Congress, concerned about growing costs, attempted various reforms . . .
The surgeon's job
Authors: H. Dinsdale
Journal: Journal of the Royal Society of Medicine (2004)

Professor Rowley (August 2004 JRSM1) correctly identifies Skills for the New Millennium: Report of the Societal Needs Working Group CanMEDS 2000 as an influential document identifying necessary elements in the area of professionalism. However, he errs in indicating it was a product of the Canadian Medical Association. It was authored by a working group of the Royal College of Physicians and Surgeons of Canada (RCPSC). The CanMEDS framework was developed and validated from 1993 to 1996. It was incorporated into Canadian specialty postgraduate education during the next six years along with enhanced material for faculty development. The CanMEDS framework of competencies that began as an initiative of forward-thinking Fellows of the RCPSC has become a popular standard for medical education around the world, including Australia, the Netherlands, Denmark and the UK.
Effects of exercise on the physical condition of college rugby players during summer training camp
Authors: T Mashiko, T Umeda, S Nakaji, K Sugawara
Journal: British Journal of Sports Medicine (2004)

To determine the effects of exercise training on physical condition in 25 college rugby players during a summer training camp, and to compare these variables by the different players' positions.Changes in body composition parameters and blood biochemistry were examined before and after a summer training camp.Body weight and percentage body fat did not change significantly during the camp. There were significant decreases in levels of serum total cholesterol, triglycerides, phosphate, uric acid, and immunoglobulin G and M. In contrast, there were significant increases in levels of serum potassium, markers of renal, hepatic, and muscular damage (BUN, GOT, GPT, LDH, CK), and complement C4. Comparison of the changes in biochemical parameters between rugby players playing in different positions showed a significant increase in serum albumin level in the forwards, and significant decreases in serum triglyceride and sodium levels in the backs. The magnitude of change in serum LDH during the camp was significantly greater (p<0.05) for the forwards than for the backs.These data suggest that, in rugby players attending a 20 day camp, exercise training resulted in muscular damage, loss of electrolytes due to sweating, and changes in immune function. Backs exhibited a higher rate of fat metabolism and loss of electrolytes than forwards, possibly because they did more running during the camp. In contrast, forwards experienced more physical contact, performed more physically strenuous exercise, and exhibited higher levels of muscular damage and tissue protein degradation.
Gentamicin Sulfate in External Eye Infections
Authors: Robert H. Magnuson
Journal: JAMA (1967)

THE NEW, broad-spectrum antiobiotic, gentamicin sulfate, is of particular interest in the treatment of eye infections. It is active against common staphylococci and streptococci,<sup>1,2</sup><i>Diplococcus pneumoniae, Haemophilus influenzae</i>,<sup>3</sup>and numerous species of gram-negative bacteria<sup>1-3</sup>including<i>Pseudomonas aeruginosa</i>. In vivo, gentamicin protected rabbit eyes against destruction from experimentally induced pseudomonal infection.<sup>4</sup>In one report of clinical use in eye infections,<sup>5</sup>a few patients were treated successfully with gentamicin sulfate ophthalmic preparation for infection with<i>Moraxella</i>(diplobacillus of Morax-Axenfeld),<i>Neisseria gonorrhoeae</i>(gonococcus), and<i>Haemophilus aegyptius</i>(Koch-Weeks bacillus). To study 0.3% gentamicin sulfate ophthalmic drops or ointment in eye infections, we treated 131 patients: 53 with the ointment, 72 with the drops, and 6 with both. Most (118) were treated for one week or less; 11 were treated for 8 to 13 days, and 2 for 20 to 30 days. Concurrent therapy included hot and cold compresses, atropine
Ischemia-induced epicardial vasoconstriction. A potential mechanism for distant myocardial ischemia.
Authors: A Chu, D E Chambers, C C Lin, W D Kuehl, F R Cobb
Journal: Circulation Research (1990)

This study evaluated the effects of transient coronary occlusion on the diameter of a nonischemic vessel or a nonischemic coronary segment proximal to the site of occlusion. Awake mongrel dogs chronically instrumented with dimension crystals, Doppler flow probes, and distal pneumatic occluders on the circumflex coronary arteries were subjected to transient 2-minute circumflex occlusions (n = 9) under constant heart rate (120 beats/min). Left ventricular end-diastolic pressure increased by 60% (from 10 +/- 1 to 16 +/- 2 mm Hg), and dP/dt decreased by 8% (from 2,048 +/- 130 to 1,885 +/- 110 mm Hg/sec); systemic hemodynamics were unaltered. Epicardial coronary diameter proximal to the site of occlusion decreased by 4.37% (from 3.62 +/- 0.25 to 3.46 +/- 0.29 mm, p less than 0.05). Constriction began 15-20 seconds after the onset of ischemia and progressed to maximum in 1-2 minutes. Combined alpha- and beta-receptor blockade (n = 8) with phentolamine (2 mg/kg) and propranolol (1 mg/kg) or cyclooxygenase inhibition (n = 5) with indomethacin (7.5 mg/kg) did not attenuate the ischemia-induced vasoconstriction response. Transient 2-minute occlusion of the left anterior descending coronary artery (n = 6) also elicited significant epicardial vasoconstriction in the circumflex coronary artery in the first minute (from 3.88 +/- 0.31 to 3.81 +/- 0.31 mm, p less than 0.05); the constriction was attenuated subsequently by an increase (25.5%) in circumflex flow. When left anterior descending occlusion was repeated (n = 6) with circumflex flow held constant, the ischemia-induced circumflex constriction was augmented; diameter decreased 3.7% (from 3.83 +/- 0.29 to 3.69 +/- 0.29 mm, p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
HFOV in premature neonates: effects on pulmonary mechanics and epithelial lining fluid cytokines. A randomized controlled trial
Authors: Giovanni Vento, Piero G. Matassa, Franco Ameglio, Ettore Capoluongo, Enrico Zecca, Luca Tortorolo, Mara Martelli, Costantino Romagnoli
Journal: Intensive Care Medicine (2005)
Points from letters: Itching in pregnancy
Authors: T H Gillison
Journal: BMJ (1975)

NHS family planning services SIR,-In the BM7 (19 July, p 185) it is re- ported that "the profession's negotiators [our italics] and the DHSS have agreed a scheme for the provision of family planning services through the hospital service, for all FP work, whether of medical or social origin."We are astonished that there has been, as yet, minimal medical or public reaction to this retrograde proposal.It is the feeling of the undersigned staff of the obstetrical and gynaecological department in Aberdeen that this scheme is indisputably bad.The reasons for its introduction are far from obvious and the advantages in terms of patient care are difficult to define.Furthermore, it may turm out to have a dangerously disruptive effect among different grades of staff in many gynaecological and anaesthetic departments, including theatre staff and porters.It seems ludicrous for a health service short of money in a time of rapid inflation to put out extra money to its highest paid workers.This is all apart from the questionable morality of the scheme and the inevitable difficulties it will present in the counselling of patients who seek unbiased family planning advice.
Depression and Oral Contraception
Authors: P. Jordan
Journal: BMJ (1970)

they have not made clear that two out of three of the seven-year survivors were in fact treated for 9 months and 22 months respec- tively by haemodialysis in other units before referral to the Royal Free, and contempor- aries of these patients at the other units concerned have died in the interim period.While in no way wishing to detract from the extremely successful results they report, it is clear that a higher mortality rate exists with this treatment when methods are being developed and there is staff inexperience.-Iam, etc..
Improved insulin sensitivity by anti-TNF antibody treatment in patients with rheumatic diseases
Authors: F. C Huvers, C. Popa, M. G Netea, F. H J van den Hoogen, C. J Tack
Journal: Annals of the Rheumatic Diseases (2006)

Insulin resistance is a key factor in the pathogenesis of the metabolic syndrome and type 2 diabetes, but the underlying mechanisms remain poorly understood. Adipocytokines, including tumour necrosis factor α (TNFα), interleukin 6, leptin and adiponectin,1,2 are increasingly recognised as important regulators of both insulin sensitivity, as well as inflammation, and a dysregulation of their levels and/or functions has been shown in both obesity and rheumatoid arthritis.3 Further investigations have substantiated the important negative effects of TNFα on insulin-mediated glucose uptake and the development of insulin resistance.4 In this study, the influence of therapeutic TNFα blockade on insulin sensitivity was investigated in regularly treated patients with rheumatic diseases.

A group of eight patients who were non-diabetic and having various chronic inflammatory disorders (table 1) were investigated in an open prospective …
Air Travel, Hypobaric Hypoxia, and Prothrombotic Changes—Reply
Authors: William D. Toff, Alison H. Goodall, Michael Greaves
Journal: JAMA (2006)

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Kallikrein-Bradykinin System in Chronic Alcoholic Liver Disease
Authors: PATRICK WONG
Journal: Annals of Internal Medicine (1972)

The kallikrein-bradykinin system was studied in patients with chronic alcoholic liver disease. Kallikreinogen levels were depressed in patients with cirrhosis when compared with levels in normal control subjects (18.8 ± 4.3 SD µmoles/ml·hr and 97 ± 24 SD µmoles/ml·hr, respectively). Levels in cirrhotics with long prothrombin times (7.8 ± 2.8 SD µmoles/ml·hr) were lower than levels in cirrhotics with normal prothrombin times (35.2 ± 20 SD µmoles/ml·hr). The lowest levels (1.5 ± 1.2 SD µmoles/ml·hr) were in three patients with hepatorenal syndrome. In contrast, Hageman factor, kallikrein inhibitor, and bradykinin levels were normal or only moderately depressed. Free kallikrein was not detected. We conclude that kallikreinogen production is impaired in alcoholic liver disease, the degree of impairment correlating well with the severity of the liver disease, and that kallikreinogen levels therefore are a sensitive index of liver dysfunction. Strong evidence was presented that the hepatorenal syndrome is not caused by elevated plasma bradykinin levels.
Effect of advertising on awareness of symptoms of diabetes among the general public: the British Diabetic Association Study
Authors: B M Singh, J J W Prescott, R Guy, S Walford, M Murphy, P H Wise
Journal: BMJ (1994)

To determine the impact of posters advertising symptoms of diabetes on public knowledge of these symptoms.Structured street interviews of members of the general public before, at the end of, and 10 weeks after a campaign advertising the main symptoms of diabetes.Basingstoke and Wolverhampton.Three samples of 1000 members of the general public were interviewed. Samples were selected randomly but stratified to match the local population's age (20-75), sex, social class, and racial characteristics.Knowledge of symptoms of diabetes; perceived seriousness of diabetes; and induction of anxiety about symptoms in the target population.Advertising significantly raised knowledge (without prompting) of symptoms: thirst, 245 before v 411 at end of campaign (P < 0.0001) v 341 after (P = 0.0012 v before); polyuria, 72 v 101 (P = 0.0211) v 92 (P = 0.5169); lethargy, 180 v 373 (P < 0.0001) v 298 (P < 0.0001); knowledge of weight loss and visual disturbance was unaffected. The number of subjects lacking knowledge of any symptoms was reduced from 550 to 388 (P < 0.0001). The perceived seriousness of diabetes was unaffected (mean 7.6 in each phase on a scale of 1 (not) to 10 (very). Before advertising, 449 (45%) claimed to have one or more symptoms of diabetes, but this number fell at the end of the campaign (403; P = 0.0419) and 10 weeks afterwards (278; P < 0.0001).An advertising campaign raised public knowledge of diabetes symptoms without inducing fear of diabetes or anxiety about symptoms. Its potential for achieving earlier detection of non-insulin dependent diabetes should be evaluated.
Recovery of renal function after delayed revascularisation of acute occlusion of the renal artery
Authors: B Williams, J Feehally, A R Attard, P R F Bell
Journal: BMJ (1988)

Une observation: une femme de 53 ans, atteinte d'hypertension, d'insuffisance cardiaque, d'insuffisance vasculaire peripherique et d'angor presente une aggravation de ces troubles et une anurie. Le rein droit est atrophique et le rein gauche normal. Apres 2 j d'essais de traitement de l'anurie le diagnostic d'obstruction de l'artere renale gauche est fait, et l'operation, 72 h apres le debut de l'anurie, est efficace
Many children remain unrestrained in cars
Authors: H. Campbell, S. MacDonald
Journal: BMJ (1997)

Editor—While we agree with the points that Ian Roberts and Carolyn DiGuiseppi make in their editorial on children in cars,1 we wish to draw attention to other important aspects of children's safety in cars. Over the past few years three surveys have been carried out on the use of restraints by car occupants in Fife, Scotland. In total, 13 933 car occupants in 7793 vehicles have been surveyed at several survey points throughout the county.2 3 In addition …
Deficiency of Thymic Stromal Lymphopoietin (TSLP) Receptor Signaling Reduced IL-33 Protein Expression and the Number of Lung Group 2 Innate Lymphoid Cells (ILC2) Following Alternaria Extract-Challenge
Authors: Shinji Toki, Kasia Goleniewska, Sara Reiss, Baohua Zhou, R. Stokes Peebles
Journal: Journal of Allergy and Clinical Immunology (2015)
Myocardial opacification by low doses EchoGen in patients: Assessment of preactivation by closed syringe suction
Authors: Bruno Cotter, Anh Duong, Ajit Raisinghani, Shahin Keramati, Ehtisham Mahmud, Oi Ling Kwan, Karen Wheeler, Anthony N. DeMaria
Journal: Journal of the American College of Cardiology (1996)