tbuckley/cabot-search huggingface dataset:
The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults
Authors: Marc-André Martel, Tomás J. Ryan, Karen F.S. Bell, Jill H. Fowler, Aoife McMahon, Bashayer Al-Mubarak, Noboru H. Komiyama, Karen Horsburgh, Peter C. Kind, Seth G.N. Grant, David J.A. Wyllie, Giles E. Hardingham
Journal: Neuron (2012)

It is currently unclear whether the GluN2 subtype influences NMDA receptor (NMDAR) excitotoxicity. We report that the toxicity of NMDAR-mediated Ca2+ influx is differentially controlled by the cytoplasmic C-terminal domains of GluN2B (CTD2B) and GluN2A (CTD2A). Studying the effects of acute expression of GluN2A/2B-based chimeric subunits with reciprocal exchanges of their CTDs revealed that CTD2B enhances NMDAR toxicity, compared to CTD2A. Furthermore, the vulnerability of forebrain neurons in vitro and in vivo to NMDAR-dependent Ca2+ influx is lowered by replacing the CTD of GluN2B with that of GluN2A by targeted exon exchange in a mouse knockin model. Mechanistically, CTD2B exhibits stronger physical/functional coupling to the PSD-95-nNOS pathway, which suppresses protective CREB activation. Dependence of NMDAR excitotoxicity on the GluN2 CTD subtype can be overcome by inducing high levels of NMDAR activity. Thus, the identity (2A versus 2B) of the GluN2 CTD controls the toxicity dose-response to episodes of NMDAR activity.
Avascular necrosis in SLE. An apparent predilection for young patients.
Authors: F E Smith, D E Sweet, C M Brunner, J S Davis
Journal: Annals of the Rheumatic Diseases (1976)

Recent reports of avascular necrosis (AN) in systemic lupus erythematosus (SLE) have suggested that its occurrence may be most frequent in young patients. In our population of 99 patients with SLE, 7 young patients have developed AN. Patterns of prednisone therapy had no apparent relationship to the development of AN. AN may become apparent in patients who have relatively inactive lupus, when increased physical activity precipitates articular collapse. A diagnosis of AN should be considered in young patients with localized joint pain.
Spontaneous development of anti-hepatitis B virus envelope (anti-idiotypic) anti-bodies in animals immunized with human liver endonexin II or with the F(ab′)2 fragment of anti-human liver endonexin II immunoglobulin G: evidence for a receptor-ligand-like relationship between small hepatitis B surface antigen and endoxin II Hertogs K, Depla E, Crabbe T, DeBruin W, Leenders W, Moshage H, Yap SH. J Virol 1994:1516–1521
Authors: M Peeples
Journal: Hepatology (1994)
An Automated Process for Layer‐by‐Layer Assembly of Polyelectrolyte Multilayer Thin Films on Viable Cell Aggregates
Authors: Joseph M. Mets, John T. Wilson, Wanxing Cui, Elliot L. Chaikof
Journal: Advanced Healthcare Materials (2012)

An automated process for modifying the surface of pancreatic islets grows uniform polyelectrolyte multilayer thin films, eliminating user variability associated with previous manual methods. Machine vision feedback allows for tight control of small fluid volumes, maintaining an islet microenvironment. This process is adaptable to other fragile micrometer-scale particle systems. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The Hospitalist Model: Perspectives of the Patient, the Internist, and Internal Medicine
Authors: Harold C. Sox
Journal: Annals of Internal Medicine (1999)

The use of hospitalists has implications for patients, for internists, and for the specialty of internal medicine. For patients, the greatest concern is interrupting the continuity of a supportive relationship with their regular physican. For many internists, the hospitalist model is attractive, but they are concerned that health plans will compel physicians to transfer their patients to a hospitalist at the time of admission to the hospital (mandatory hand-off). Thus, the hospitalist could become the means to exclude internists from hospital care and deprive them of an important source of professional satisfaction. The specialty of internal medicine is very concerned about the mandatory hand-off because it threatens the internist's identity as the physician who can care for the sickest patients in any venue, making it harder for patients and health plans to distinguish the internist from family physicians and nurse practitioners. The hospitalist movement has much to offer internal medicine. To enjoy the benefits and avoid the harms associated with the hospitalist model, internal medicine must resist the imposition of the mandatory hand-off and use the hospitalist's focus on excellent inpatient care to improve the practice of medicine by all internists.
Angiotensin-II type 1 receptor interaction is a major regulator for liver fibrosis development in rats
Authors: Hitoshi Yoshiji, Shigeki Kuriyama, Junichi Yoshii, Yasuhide Ikenaka, Ryuichi Noguchi, Toshiya Nakatani, Hirohisa Tsujinoue, Hiroshi Fukui
Journal: Hepatology (2001)

The renin-angiotensin system (RAS) is frequently activated in patients with chronic liver diseases. Angiotensin-II (AT-II) has been suggested to play an important role in liver fibrogenesis. It induces hepatic stellate cell (HSC) proliferation and up-regulates the transforming growth factor beta(1) (TGF-beta(1)) expression via AT-II type 1 receptor (AT(1)-R) in vitro. The aim of the present study was to examine the in vivo effect of candesartan (CA), a clinically used AT(1)-R blocker (ARB), and perindopril (PE), an angiotensin-converting enzyme (ACE) inhibitor (ACE-I), on pig serum-induced liver fibrosis development in rats. The clinically available comparable doses of CA and PE significantly attenuated the fibrosis development. These inhibitory effects of PE and CA were also found in the on-going liver fibrosis model. The hepatic hydroxyproline and serum fibrosis markers were significantly suppressed by CA and PE treatment. Furthermore, the alpha smooth muscle actin (alpha-SMA) positive cells in number were markedly suppressed by CA and PE treatment. Similarly, the hepatic TGF-beta(1) protein and messenger RNA (mRNA) levels were significantly suppressed. Our in vitro study showed that AT-II increased the TGF-beta(1) mRNA expression in the activated HSCs, and this effect was totally blocked by CA. These results suggested that the RAS, especially AT-II and AT(1)-R interaction plays a pivotal role in liver fibrosis development through HSC activation. Because both CA and PE are widely used in clinical practice without serious side effects, these drugs may provide an effective new strategy for anti-liver fibrosis therapy.
Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice
Authors: Elizabeth S. Raveche, Erica Salerno, Brian J. Scaglione, Vijaya Manohar, Fatima Abbasi, Yi-Chu Lin, Torgny Fredrickson, Pablo Landgraf, Sumant Ramachandra, Konrad Huppi, Jorge R. Toro, Vincent E. Zenger, Robert A. Metcalf, Gerald E. Marti
Journal: Blood (2007)
Myocardial infarct size and ventricular function in rats.
Authors: M A Pfeffer, J M Pfeffer, M C Fishbein, P J Fletcher, J Spadaro, R A Kloner, E Braunwald
Journal: Circulation Research (1979)

To define the relationship between infarct size and ventricular performance, we performed hemodynamic studies in rats 21 days after left coronary artery occlusion. Ventricular performance was assessed under ether anesthesia by measurements of baseline hemodynamics and stressed performance as determined by the peak cardiac output and stroke volume obtained during intravenous volume loading and by the peak left ventricular developed pressure obtained during occlusion of the ascending aorta. Infarct size was determined by planimetry of the endocardial circumference of each of four histological slices of the left ventricle. Rats with small (4-30%) myocardial infarctions had no discernible impairment in either baseline hemodynamics or peak indices of pumping and pressure-generating ability when compared to the sham-operated, noninfarcted rats. Rats with moderate (31-46%) infarctions had normal baseline hemodynamics but reduced peak flow indices and developed pressure. Rats with infarctions greater than 46% had congestive heart failure, with elevated filling pressures, reduced cardiac output, and a minimal capacity to respond to pre- and after load stresses. The entire spectrum of postinfarction ventricular function was observed, from no detectable impairment to congestive failure. In this model of histologically healed myocardial infarction, the impairment of left ventricular function was directly related to the loss of myocardium.
Occupational IgE‐mediated rhinitis caused by ninhydrin
Authors: M. Hytönen, K. P. Martimo, T. Estlander, O. Tupasela
Journal: Allergy (1996)

Ninhydrin is a laboratory chemical used as a reagent in the detection of free amino and carboxyl groups in proteins and peptides. We present the case of a laboratory technician who developed symptoms of rhinitis when handling papers immersed in a solution containing ninhydrin. Prick tests for ninhydrin and ninhydrin RAST were positive. The inhalation provocation test in an exposure chamber gave an immediate nasal response. A positive prick test to ninhydrin, an elevated level of specific IgE antibodies to ninhydrin, and the RAST inhibition test confirmed an IgE‐mediated type I allergic reaction. We are not aware of any other report of ninhydrin as a cause of IgE‐mediated allergy.
Editorial: Laughing all the way to the bank
Authors: S. Vaisrub
Journal: JAMA (1974)

Physicians have been, for long, favorite targets of the layman's humor. Look at ludicrous literary caricatures like Diaphorus in Molière's<i>Le Medicin Malgré Lui</i>or Bob Sawyer in Dickens'<i>The Pickwick Papers</i>; and for jocular epigrams, remember "doctors bury their mistakes," or amusing tales told by stock brokers about the vagaries of physician-investors. Have doctors retaliated in kind? Have they matched their wits with their deriders? Although not lacking in a sense of humor, doctors do not, as a rule, exercise it in their relations with hospital administrators, government officials, drug manufacturers, and especially—repeat, especially—patients. Had O. Henry been a doctor he would have been rapped on the knuckles for his famous remark that fat women and patients with hay fever attest to God's sense of humor. Even news media operators enjoy a kind of diplomatic immunity from barbs of medical wit, despite their often grotesque medical news coverage. Against
General practitioner training in paediatrics in the Trent region.
Authors: L. Polnay, M. Pringle
Journal: BMJ (1989)

A total of 259 postal questionnaires were sent to all final year vocational trainees and new principals in general practice in the Trent region to find out how much training in paediatrics they had had. Questionnaires were returned by 105 trainees and 139 principals (244; 94%). Overall 72% (175) had taken up a hospital post in paediatrics during training, but among the 138 doctors who were on or had completed a three year vocational training scheme the proportion was slightly higher (82%; 115) (p = 0.01). Among the 175 who had had a post in paediatrics 108 (62%) had been given teaching sessions every week, and for half of these doctors the sessions lasted over one hour a week. Seventy five (54%) of the 139 principals reported that in their training in a general practice they had received no teaching about child health and a fifth said that they had not attended a clinic for children; 47 (34%) had received no training on procedures for dealing with cases of child abuse. The doctors who had held posts as senior house officers in paediatrics were more likely to report that they had adequate skills in paediatrics than those who had not, but overall only 62 (44%) reported that they could run a preschool child health surveillance programme. Extra paediatric posts in hospital are needed, but in the mean time improvements can be made to the teaching content in hospital and in the general practice attachment and postgraduate training in paediatrics provided for all general practitioners.
Absence of the Eighth Component of Complement in Association with Systemic Lupus Erythematosus-Like Disease
Authors: Hugo E. Jasin
Journal: Journal of Clinical Investigation (1977)

A 56-yr-old black woman with absence of the eighth component of complement and a disease compatible with systemic lupus erythematosus is described. Her disease is characterized by the presence of photosensitive “malar” rash, alopecia, polyarthritis, and nephrotic syndrome.
Efficacy Data and HPV Vaccination Studies
Authors: Rebecca B. Perkins
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical and Metabolic Studies in Nontropical Sprue
Authors: Marvin H. Sleisenger
Journal: New England Journal of Medicine (1961)

OVER a period of seven years, my colleagues and I have treated 29 patients with nontropical sprue by eliminating gluten from their diets. The average age of this series of 26 women and 3 men was forty-five and five-tenths years, with a range of twenty-two to sixty-eight, and the peak incidence was in the sixth decade. The average duration of illness was fourteen years; 13 of 29 (45 per cent) were ill for more than fifteen years, and 3 patients had symptoms for more than thirty-five years. Eight (28 per cent) either had celiac disease or reported its occurrence in . . .
Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells
Authors: Mariska G. Rondaij, Ruben Bierings, Ellen L. van Agtmaal, Karina A. Gijzen, Erica Sellink, Astrid Kragt, Stephen S. G. Ferguson, Koen Mertens, Matthew J. Hannah, Jan A. van Mourik, Mar Fernandez-Borja, Jan Voorberg
Journal: Blood (2008)
The Value of Magnetic Resonance Imaging of the Left Ventricular Outflow Tract in Patients With Hypertrophic Obstructive Cardiomyopathy After Septal Artery Embolization
Authors: Jeanette Schulz-Menger, Oliver Strohm, Jürgen Waigand, Frank Uhlich, Rainer Dietz, Matthias G. Friedrich
Journal: Circulation (2000)

We tested the value of magnetic resonance imaging (MRI) in the follow-up of patients with hypertrophic obstructive cardiomyopathy after septal artery embolization. MRI provides a noninvasive visualization of transplanar turbulent flow in order to quantify left ventricular outflow tract obstruction.We followed 10 patients who were treated with septal artery embolization for 12 months. We used gradient echo sequences to document continuous improvement of the outflow tract area and T1- and T2-weighted spin echo sequences to visualize myocardial infarction. A continuous, but not linear, improvement of the outflow tract area occurred after septal artery embolization during the 12-month follow-up period. The improvement of the outflow tract area correlated well with the amelioration of symptoms (r(2)=0.86).We conclude that MRI reliably detects the degree of obstruction in patients with hypertrophic obstructive cardiomyopathy. This modality may be especially useful for follow-up after septal artery embolization.
Neuroanatomy: A Programmed Text
Authors: Wendell J. S. Krieg
Journal: JAMA (1965)

The Doctors Sidman are brothers, Richard, professor of neuropathology at Harvard, Murray, of psychology. For a programmed workbook in clinically oriented neuroanatomy, the combination should be unbeatable. The 645 pages of this book contain 1,318 items, each in the form of a sentence or paragraph with missing words to fill in, and usually with a small diagram which in many cases is a 3-D phantom rendering. The small size of the cuts, however, precludes the secondary shading that is necessary for stereoscopic illusion.  The present volume (a second volume is in preparation) includes about half of the subject matter of neuroanatomy: upper and lower motor systems, somesthetic system, spinal cord—the subjects best suited, by their positive quality and clinical applications, to this treatment. For the complete set, a medical student will make an investment of, presumably, some $23 in addition to a textbook, and the book cannot be reused if filled in.
Long-term follow-up after endoscopic forceps biopsies for early stage duodenal carcinoid: case report and review of endoscopic treatments
Authors: E. Urso, S. Pucciarelli, M. Cassaro, M. Agostini, D. Nitti
Journal: Endoscopy (2007)

Duodenal carcinoids are neuroendocrine tumors that account for 2 % to 13.6 % of all gastrointestinal carcinoids, and no guidelines are available for their treatment. Small (< 2 cm) nonperiampullary duodenal carcinoids without submucosal invasion have been termed early stage duodenal carcinoids (esDC) [1]; their clinical course appears favorable and endoscopic treatment would seem to be a feasible treatment option. We report on a female patient treated for an 8-mm polyp of the duodenal bulb, which was diagnosed as a carcinoid after forceps biopsies. At the subsequent check up, the patient was free of disease. At 11 years later, after 12 annual endoscopic examinations and periodic monitoring with abdominal computed tomography (CT) scan and octreotide scintigraphy, there was a recurrence of the neuroendocrine tumor, present in a biopsy of the duodenal scar. No further signs of carcinoid were found at the examination that followed shortly afterwards and so no further treatment was proposed. At 2 years after the recurrence, the patient is disease-free.
Another Smoking Gun Linking Cigarettes and Heart Disease
Authors: Peter F. Cohn
Journal: JAMA (1989)

That cigarette smoking is harmful to the heart has long been maintained by a variety of concerned health professionals— and just as vehemently denied by the tobacco industry. This denial is made possible because the evidence linking cigarette smoking to ischemic heart disease is largely indirect and circumstantial, ie, smokers have a greater chance of developing and dying from coronary artery disease than do nonsmokers. This association has been confirmed by one epidemiologic survey after another, but what is lacking are smoking guns, direct connections between cigarettes and cardiac pathophysiology. In this issue ofThe Journal, Barry and colleagues<sup>1</sup>supply a smoking gun that is especially important because it relates to real-life settings rather than the experimental laboratory. The smoking gun is really a small box, the Holter monitor, previously used only to record arrhythmias and conduction disturbances but in the last several years adapted to a new use—the
Asymptomatic left main coronary artery disease in the Coronary Artery Surgery Study (CASS) registry.
Authors: H A Taylor, N J Deumite, B R Chaitman, K B Davis, T Killip, W J Rogers
Journal: Circulation (1989)

Left main coronary artery disease (i.e., greater than or equal to 50% stenosis) was found in 1,477 of 20,137 patients in the Coronary Artery Surgery Study (CAS) registry. Of these patients, 53 (3.6%) were asymptomatic. Asymptomatic and symptomatic patients were similar in regard to 1) severity of left main coronary artery stenosis (67% vs. 70%), 2) extent of proximal coronary artery disease (no differences in number of or severity of proximal stenoses), 3) left ventricular end-diastolic pressure (13 mm Hg vs. 14 mm Hg), 4) left ventricular wall motion score 9.1 vs. 8.7), and 5) number of coronary artery segments with greater than 70% stenosis (4.4 vs. 4.8). Among the asymptomatic patients, 47% received medical and 49% received surgical treatment. In the symptomatic group, 20% received medical and 78% received surgical therapy. The survival rate 5 years after surgery for treatment of left main coronary artery stenosis was 84% for the symptomatic patients and 88% for the asymptomatic patients (p = NS). Medical management of left main coronary artery disease produced a 5-year survival rate of 57% for asymptomatic patients and 58% for symptomatic patients. Within the asymptomatic subgroup, 88% of those surgically treated survived 5 years, whereas only 57% of those medically treated survived 5 years (p = 0.02). Thus, for CASS patients with left main coronary artery disease, the percentage of those that were asymptomatic is low (3.6%); asymptomatic and symptomatic patients with left main coronary artery disease had no significant difference in severity of left main coronary artery stenosis, extent of overall coronary artery disease, or left ventricular function.(ABSTRACT TRUNCATED AT 250 WORDS)
Short-Term Effects of Transdermal Estrogen Replacement Therapy on Coronary Vascular Reactivity in Postmenopausal Women With Angina Pectoris and Normal Results on Coronary Angiograms
Authors: Mercè Roqué, Magda Heras, Eulàlia Roig, Mònica Masotti, Montserrat Rigol, Amadeu Betriu, Juan Balasch, Ginés Sanz
Journal: Journal of the American College of Cardiology (1998)
Lark-and-Elephant Pie Meets Humble Pie
Authors: Drummond Rennie
Journal: Annals of Internal Medicine (1993)

Letters15 February 1993Lark-and-Elephant Pie Meets Humble PieDrummond Rennie, MDDrummond Rennie, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-4-199302150-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:While reading and greatly admiring your wise editorial [1] on the importance of the physical diagnosis, I came across your citation, both in the text and the references (number 7), to an equally admirable and wise editorial written by Sackett. The latter introduces an exciting series in JAMA by which the art and science of history-taking and physical examination are being analyzed, criticized, quantified, and perhaps revolutionized.Something stirred in my memory, and I pulled the reference to confirm that this was indeed the masterly description and inspired prescription that had so struck me when it first ...References1. Fletcher RH, Fletcher SW. Has medicine outgrown physical diagnosis? Ann Intern Med. 1992; 117:786-7. Google Scholar2. Sackett DL, Rennie D. The science of the art of the clinical examination. JAMA. 1992; 267:2650-2. Google Scholar Author, Article, and Disclosure InformationAuthors: Drummond Rennie, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 February 1993Volume 118, Issue 4 Page: 320 Keywords Memory ePublished: 15 August 2000 Issue Published: 15 February 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...