tbuckley/cabot-search huggingface dataset:
Future provision of out of hours primary medical care: a survey with two general practitioner research networks
Authors: V. Lattimer, H. Smith, P. Hungin, A. Glasper, S. George
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objective</b>: To ascertain general practitioners9 views about the future provision of out of hours primary medical care. <b>Design</b>: Self completing postal questionnaire survey. <b>Setting</b>: Wessex and north east England. <b>Subjects</b>: 116 general practitioners in the Wessex Primary Care Research Network and 83 in the Northern Primary Care Research Network. <b>Main outcome measures</b>: Intention to reduce or opt out of on call; plans for changing out of hours arrangements; the three most important changes needed to out of hours care; willingness to try, and perceived strengths and limitations of, three alternative out of hours care models—primary care emergency centres, telephone triage services, and cooperatives. <b>Results</b>: The overall response rate was 74% (Wessex research network 77% (89/116), northern research network 71% (59/83)). Eighty three per cent of respondents (123/148) were willing to try at least one service model, primary care emergency centres being the most popular option. Key considerations were the potential for a model to reduce time on call and workload, to maintain continuity of care, and to fit the practice context. Sixty one per cent (91/148) hoped to reduce time on call and 25% (37/148) hoped to opt out completely. <b>Conclusion</b>: General practitioners were keen to try alternative arrangements for out of hours care delivery, despite the lack of formal trials. The increased flexibility in funding brought about by the recent agreement between the General Medical Services Committee and the Department of Health is likely to lead to a proliferation of different schemes. Careful monitoring will be necessary, and formal trials of new service models are needed urgently. <h3>Key messages</h3> Key messages Over 80% of general practitioners in two research networks were willing to try a new out of hours service for their practice—either a primary care emergency centre, a telephone triage service, or a cooperative; cooperatives were the least favoured option The most important changes needed to out of hours care concerned financial arrangements, regulations, and patient education Formal trials of new services are needed before the opportunity to collect baseline data is lost
More than a third of people with abnormal bowel cancer screening results avoid later screening
Authors: S. Mayor
Journal: BMJ (2015)

Almost 40% of people who have abnormal results from bowel cancer screening and are referred for further investigations do not attend follow-up screening two years later, a study of the national screening programme in England has warned.

Researchers followed up participants in the NHS bowel cancer screening programme,1 which offers faecal occult blood testing to people aged 60-74 on three occasions, each two years apart. …
Social research company threatens CHC with libel suit
Authors: C. Dyer
Journal: BMJ (2013)

A community health council (CHC) in Wales and its volunteer chair and vice chair have been threatened with a libel action over a report it sent to the Welsh government about a consultation on proposed changes to local NHS services.

Opinion Research Services (ORS), which was commissioned by Hywel Dda health board to work on the “Your Health Your Future” consultation, has sent a solicitor’s letter threatening to sue Hwyel Dda CHC, its chair, and vice chair, unless they remove allegedly defamatory statements, apologise, and …
Caffeic acid phenethyl ester reduces the activation of the nuclear factor κB pathway by high-fat diet-induced obesity in mice
Authors: Rosângela Maria Neves Bezerra, Lucimara Fernanda Veiga, Aline Camila Caetano, Pedro Luiz Rosalen, Maria Esméria Corezola Amaral, Adrianne Christine Palanch, Severino Matias de Alencar
Journal: Metabolism (2012)
Postpartum Depression
Authors: Katherine L. Wisner, Christina Chambers, Dorothy K. Y. Sit
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P3-071: Respiratory symptoms improvement in non-resectable adenocarcinoma with bronchioloalveolar carcinoma features (ADC-BAC) treated with gefitinib: Quality of Life analysis of the IFCT-0401 trial
Authors: Franck Morin, Quan Tran, Pascal Debove, Jean-Charles Soria, Denis Moro-Sibilot, Pierre-Jean Souquet, Sylvie Friard, Patrick Merle, Jacques Cadranel
Journal: Journal of Thoracic Oncology (2007)
Bacterial Infection and MALT Lymphoma
Authors: Julie Parsonnet, Peter G. Isaacson
Journal: New England Journal of Medicine (2004)

Fifty years ago, the idea that infectious agents caused lymphoma would have seemed heretical. Although viruses were known to cause tumors in animals, they were not considered a cause of disease in humans — that simply was not what infections did. Rather, tumors were considered to be the consequence of environmental exposures and of inherited genetic abnormalities. This view began to change 35 years ago, when a rare form of non-Hodgkin's lymphoma — Burkitt's lymphoma — was found to be closely associated with Epstein–Barr virus (EBV). The relationship between EBV infection and lymphoma, however, was considered to be an anomaly, . . .
Overdrive Pacing for Ventricular Tachyarrhythmias: A Reassessment
Authors: PETER R. KOWEY
Journal: Annals of Internal Medicine (1983)

Overdrive pacing was used for many years to prevent ventricular tachycardia and there are many reports of its effectiveness. Nevertheless, the use of overdrive pacing for most types of ventricular tachyarrhythmia has been abandoned. One notable exception is torsades de pointes, in which interventions that increase heart rate, including pacing, at least temporarily protect against recurrence. Overdrive may work by narrowing dispersion of ventricular refractoriness, and measurement of the latter could provide a marker to selectively apply overdrive pacing, thus increasing its usefulness.
Only three mutations account for almost all defective alleles causing adenine phosphoribosyltransferase deficiency in Japanese patients.
Authors: N Kamatani, M Hakoda, S Otsuka, H Yoshikawa, S Kashiwazaki
Journal: Journal of Clinical Investigation (1992)

We analyzed mutant alleles of adenine phosphoribosyltransferase (APRT) deficiency in Japanese patients. Among 141 defective APRT alleles from 72 different families, 96 (68%), 30 (21%), and 10 (7%) had an ATG to ACG missense mutation at codon 136 (APRT*J allele), TGG to TGA nonsense mutation at codon 98, and duplication of a 4-bp sequence in exon 3, respectively. The disease-causing mutations of only four (3%) of all the alleles among Japanese remain to be elucidated. Thus, a diagnosis can be made for most of the Japanese APRT-deficient patients by identifying only three disease-causing mutations. All of the different alleles with the same mutation had the same haplotype, except for APRT*J alleles, thereby suggesting that alleles with the same mutation in different families were derived from the same ancestral gene. Evidence for a crossover or gene conversion event within the APRT gene was observed in an APRT*J mutant allele. Distribution of mutant alleles encoding APRT deficiency among the Japanese was similar to that seen in cystic fibrosis genes among Caucasians and Tay-Sachs genes among the Ashkenazi Jews.
Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy
Authors: Sean H. Lim, Andrew T. Vaughan, Margaret Ashton-Key, Emily L. Williams, Sandra V. Dixon, H. T. Claude Chan, Stephen A. Beers, Ruth R. French, Kerry L. Cox, Andrew J. Davies, Kathleen N. Potter, C. Ian Mockridge, David G. Oscier, Peter W. M. Johnson, Mark S. Cragg, Martin J. Glennie
Journal: Blood (2011)
Left atrial enlargement and NT‐proBNP as predictors of sudden cardiac death in patients with heart failure
Authors: Antoni Bayes‐Genis, Rafael Vazquez, Teresa Puig, Carlos Fernandez‐Palomeque, Jordi Fabregat, Alfredo Bardají, Domingo Pascual‐Figal, Jordi Ordoñez‐Llanos, Mariano Valdes, Albert Gabarrús, Ricardo Pavon, Luis Pastor, Jose Ramon Gonzalez Juanatey, Jesus Almendral, Miquel Fiol, Vicente Nieto, Carlos Macaya, Juan Cinca, Antoni Bayes de Luna
Journal: European Journal of Heart Failure (2007)
1018-150 16-slice multidetector-row computed tomography and magnetic resonance imaging for the in vivo and noninvasive assessment of vessel areas and diameters
Authors: Juan Federico Viles-Gonzalez, Michael Poon, Javier Sanz, Teresa Ruis, Konstantin Nikolaou, Zahi Adel Fayad, Valentin Fuster, Juan Jose Badimon
Journal: Journal of the American College of Cardiology (2004)
Home Intravenous Antibiotic Therapy: A Team Approach
Authors: SUSAN J. REHM
Journal: Annals of Internal Medicine (1983)

Prolonged hospitalization for therapy of some infections may be economically and emotionally costly to patients. A multidisciplinary team was organized at the Cleveland Clinic Hospital to coordinate the selection, education, and follow-up of patients receiving parenteral antibiotic therapy at home. Forty-eight patients were trained to mix and administer antibiotics and to care for the intravenous access device. Most patients had infections of the bones, joints, or soft tissues and received an average of 19 days of therapy at home. Beta-lactam antibiotic agents were administered to most patients and were well tolerated. The infection was eradicated in 87% of patients. The average saving in cost for each course of treatment was $5728.
Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America
Authors: Camila Alexandrina Figueiredo, Leila D. Amorim, Neuza M. Alcantara-Neves, Sheila M.A. Matos, Philip J. Cooper, Laura C. Rodrigues, Mauricio L. Barreto
Journal: Journal of Allergy and Clinical Immunology (2013)
Phase II Trial
Authors: John Graham-Pole
Journal: Annals of Internal Medicine (1994)

Ad Libitum15 April 1994Phase II TrialJohn Graham-Pole, MDJohn Graham-Pole, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-8-199404150-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail A lifetime of steady schooling—alphabet-rote, number-recital,history date, geography location,shoetie, jumprope, bikeride, slowdance,how we are born, grow, age, die—hasn't readied me for the cold synopsisof your Consent Form.A lifetime of educated modesty—bedroom door closing, body covering,segregating girls from boys,separate amenities for men and women,learned euphemisms for my body's functions—hasn't readied me for your free inspectionof my daily portapotti.A lifetime of careless risk-taking—climbing oaktrees, diving rockpools,homeruns, hardballs, hookshots, headlocks,driving dragsters, shooting the tube,rash rollercoaster thrillseeking—hasn't readied me for the chill realityof this life-challenge.running in the middle of the pack,... Author, Article, and Disclosure InformationAuthors: John Graham-Pole, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1994Volume 120, Issue 8 Page: 691 Keywords Climbing Phase 2 trials Rashes Running ePublished: 15 August 2000 Issue Published: 15 April 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Diagnosing Insulin Resistance by Simple Quantitative Methods in Subjects With Normal Glucose Metabolism
Authors: Juan F. Ascaso, Susana Pardo, José T. Real, Rosario I. Lorente, Antonia Priego, Rafael Carmena
Journal: Diabetes Care (2003)

OBJECTIVE—To identify a reliable yet simple indirect method for detection of insulin resistance (IR). RESEARCH DESIGN AND METHODS—A total of 65 subjects (44 men and 21 women aged 30–60 years) were selected by a simple random sampling method. Inclusion criteria were voluntary participation from staff and hospital personnel, absence of abnormal glucose tolerance, and normal results of lipid profile and basic blood chemistry. A blood sample was taken after a 12-h overnight fast to determine plasma lipid, glucose, and insulin levels. An intravenous glucose tolerance test with administration of insulin after 20 min and extraction of multiple blood samples for glucose and insulin measurements and calculation of the minimal model approximation of the metabolism of glucose (MMAMG) Si value were performed. Three indirect indexes used to predict insulin sensitivity or IR were calculated, and metabolic syndrome was diagnosed using the Adult Treatment Panel III (ATP III) criteria. All results were correlated with those of the MMAMG. RESULTS—The 75th percentile value as the cutoff point to define IR corresponded with a fasting plasma glucose level of 12 mU/l, a homeostasis model assessment of 2.6, a 25th percentile for Si value of 21, and QUICKI (quantitative insulin sensitivity check index) and McAuley indexes of 0.33 and 5.8, respectively. The Si index correlated (P &amp;lt; 0.001) with all the indirect indexes and parameters of the metabolic syndrome. CONCLUSIONS—When compared with the Si index, the most sensitive and specific indirect method was the score proposed by McAuley et al. (specificity 0.91, sensitivity 0.75, 9.2 probability ratio of a positive test), followed by the existence of metabolic syndrome (specificity 0.91, sensitivity 0.66, 7.8 probability ratio of a positive test).
Implementation of Evidence-based Asthma Interventions in Post-Katrina New Orleans: The Head-off Environmental Asthma in Louisiana (HEAL) Study
Authors: Herman Mitchell, Richard D. Cohn, Jeremy Wildfire, Eleanor Thornton, Suzanne Kennedy, Jane M. El-Dahr, Patricia C. Chulada, Mosanda M. Mvula, L. Faye Grimsley, Maureen Y. Lichtveld, LuAnn E. White, Yvonne M. Sterling, Kevin U. Stephens, William J. Martin
Journal: Environmental Health Perspectives (2012)

Childhood asthma morbidity and mortality in New Orleans, Louisiana, is among the highest in the nation. In August 2005, Hurricane Katrina created an environmental disaster that led to high levels of mold and other allergens and disrupted health care for children with asthma.
Community Screening Programs for Diabetes?
Authors: Kelly M West
Journal: Diabetes Care (1979)

Considerable uncertainty and disagreement now prevail concerning the utility and priority of community screening programs for diabetes. A large majority of diabetologists believe that substantial benefits attend the early discovery of diabetes. Official statements of the American Diabetes Association support the view that mitigation of hyperglycemia lowers risk of morbidity. Much recent evidence indicates that aggressive early treatment often improves beta-cell function, thereby diminishing the severity of diabetes. Even so, some diabetologists and public health specialists question the practical benefits of community screening programs. Indeed, there is considerable evidence that, as previously performed, results sometimes have not justified costs. This article suggests that, when well designed, community screening is stil justified in some circumstances. To a considerable degree, failures of the past are correctable. The American Diabetes Association should neither approve nor disapprove community screening indisciminately. Affiliate organizations and health departments should be free to examine available evidence and local circumstances and, then, to decide whether to undertake screening programs. More care is needed in planning, executing, and critically evaluating these programs, but there is impressive and mounting evidence supporting the potential utility of the early discovery of diabetes.
Depression and Survival Following Myocardial Infarction-Reply
Authors: Margaret A. Chesney
Journal: JAMA (1994)

<h3>In Reply.</h3> —Dr Cleophas is worried that behavioral interventions aimed at reducing the adverse impact of psychosocial factors in patients who had an MI would not do any good for the 84% who were not depressed. We remind him that none of the clinical trials of psychosocial interventions in either coronary heart disease or cancer that we cited in our Editorial had selected patients who were depressed; yet in each trial there was a favorable impact on prognosis. The psychosocial interventions used in these successful trials addressed not only the problems of depression but also aimed to reduce the impact of other harmful factors, such as social isolation and hostile, competitive, and impatient behavior, among heart disease victims. We cannot be sure what proportion of patients having an MI are placed at higher risk by these other characteristics. Nevertheless, it is surely a larger proportion than the 16% with major
The Counterfeit Ark: Crisis Relocation for Nuclear War
Authors: Matthew Zack
Journal: JAMA (1984)

"Counterfeit ark" refers to current efforts of the US Federal Emergency Management Agency to save civilian lives in a massive nuclear attack by relocating those living in areas at high risk of direct thermal and blast effects and sheltering them in low-risk rural areas. The contributors to the 15 chapters of this book examine the assumptions underlying these civil defense efforts in crisis relocation planning. They argue that these efforts give a false sense of security because such plans cannot achieve the intended goal of saving 80% of the American population after a 6,600-megaton nuclear attack by the Soviet Union. Excerpts from recent documents that rationalize these relocation plans begin 14 of the chapters and act as convenient foils. The first seven chapters, "Before the Flood," question the rationale of the plans for the interval before the attack. Can other disasters suggest what the disaster from nuclear war will be
DDAVP in the Treatment of Central Diabetes Insipidus
Authors: Alan G. Robinson
Journal: New England Journal of Medicine (1976)

DDAVP, 1-desamino-8-d-arginine-vasopressin, is a synthetic analogue of vasopressin with increased antidiuretic activity and decreased pressor activity. Whereas the antidiuretic-to-pressor ratio of arginine vasopressin is 1, the antidiuretic-to-pressor ratio of DDAVP is 4000. When administered as an intranasal spray, 5 to 20 μg of DDAVP produced eight to 20 hours of antidiuresis in patients with complete central diabetes insipidus. The minimum recommended therapeutic dose resulted in a maximum antidiuresis in most patients. No side effects of the drug were noted in clinical trials. DDAVP thus gives promise of becoming the standard treatment of severe central diabetes insipidus. (N Engl J Med 294:507–511, 1976)
Clinical Heterogeneity of Patients With Adult-Onset Diabetes and GAD Autoantibodies
Authors: Michiaki Fukui, Yoshihiro Kitagawa, Naoto Nakamura, Toshikazu Yoshikawa
Journal: Diabetes Care (2002)

We read with great interest the recent article by Takeda et al. (1) reporting that GAD autoantibody (GADab)-positive non-insulin-deficient patients differ from GADab-positive insulin-deficient patients with respect to clinical characteristics, humoral autoimmunity to other organ-specific autoantibodies, and HLA class II genes.

The prevalence of GADab in Takeda’s study was lower than that in our study (3.8 vs. 6.8%; P = 0.0009 by χ2 analysis), even in patients who were initially diagnosed as having type 2 diabetes (2). The authors should present the number of patients with insulin-deficient and non-insulin-deficient diabetes and the prevalence of GADab in both groups of patients. We speculate that the lower …
Eight-Day Survival Without Adrenal Steroids
Authors: Jitender Jain
Journal: JAMA (1977)

A patient with advanced breast cancer who had undergone a total bilateral adrenalectomy in the past refused adrenal steroid replacement therapy with the idea that this would be the easiest and quickest way to end her life. However, she continued to live for more than eight days. Survival under these circumstances is unusual, and the terminal course of her illness is described. (<i>JAMA</i>237:1715-1716, 1977)
Medical Malpractice Claims since the Crisis of 1975: Some Good News and Some Bad
Authors: William J. Curran
Journal: New England Journal of Medicine (1983)

THE insurance system in the United States for protection of physicians and hospitals against financial loss due to malpractice claims almost collapsed in 1975. Many private insurance carriers withdrew from the field, and the remaining companies increased their premiums in one year from 100 to 750 per cent.1 The impact on many practitioners was catastrophic. Radical restructuring of the malpractice system, with extensive tort-law reforms, was sought from the state legislatures, and nearly all responded.Among the most important reforms were the adoption of arbitration systems and pretrial screening panels designed to direct the handling of claims away from the . . .
Antiemetics in Patients Receiving Chemotherapy for Cancer
Authors: Stephen E. Sallan, Carol Cronin, Marvin Zelen, Norman E. Zinberg
Journal: New England Journal of Medicine (1980)

Delta-9-tetrahydrocannabinol (THC) is an effective antiemetic as compared with placebos in patients receiving chemotherapy for cancer. In this study we compared THC with prochlorperazine (compazine) in a randomized, double-blind, crossover trial with patients who had failed to benefit from standard antiemetic therapy. Regardless of the emetic activity of the chemotherapeutic agents, there were more complete responses to THC courses (in 36 of 79 courses) than to prochlorperazine (in 16 of 78 courses). Of 25 patients who were treated with both drugs and who expressed a preference, 20 preferred THC (P = 0.005). Among patients under 20 years of age there was a higher proportion of complete responses to THC courses (15 of 20) than among older patients (21 of 59 courses; P = 0.004). Increased food intake occurred more frequently with THC (P = 0.008) and was associated with the presence of a "high." Of 36 THC courses resulting in complete antiemetic responses, 32 were associated with a high. We conclude that THC is an effective antiemetic in many patients who receive chemotherapy for cancer and for whom other antiemetics are ineffective. (N Engl J Med 302:135--138, 1980).