Fluoride Therapy for the Vertebral Crush Fracture Syndrome
Authors: Robert P. Heaney
Journal: Annals of Internal Medicine (1989)

Position Papers15 October 1989Fluoride Therapy for the Vertebral Crush Fracture SyndromeA Status ReportRobert P. Heaney, MD, David J. Baylink, MD, C. Conrad Johnston Jr., MD, L. Joseph Melton III, MD, Pierre J. Meunier, MD, Timothy M. Murray, MD, Charles Nagant de Deuxchaisnes, MDRobert P. Heaney, MDSearch for more papers by this author, David J. Baylink, MDSearch for more papers by this author, C. Conrad Johnston Jr., MDSearch for more papers by this author, L. Joseph Melton III, MDSearch for more papers by this author, Pierre J. Meunier, MDSearch for more papers by this author, Timothy M. Murray, MDSearch for more papers by this author, Charles Nagant de Deuxchaisnes, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-8-678 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFluoride has been proposed as a therapy for the vertebral crush fracture syndrome for many years; such proposals have been based largely on the well-characterized syndrome of fluoride intoxication (fluorosis), which is marked by increased skeletal mass and sometimes exuberant bony overgrowths (1-4). For various reasons, including the inability to develop a patentable product, the clinical studies necessary to follow this lead and establish efficacy and safety have proceeded slowly. Nevertheless, much information on fluoride use in the treatment of the vertebral crush fracture syndrome has been amassed, and during the past 9 years fluoride therapy has been approved for...References1. Roholm K. Fluoride Intoxication: A Clinical-Hygienic Study; with a Review of the Literature and Some Experimental Investigations. London, England: H. K. Lewis & Company; 1937. Google Scholar2. SinghJollyBansalMathur ASBC. Endemic fluorosis: epidemiological, clinical and biochemical study of chronic fluorine intoxication in Panjab (India). Medicine. 1963;42:229-46. CrossrefMedlineGoogle Scholar3. RichEnsinckIvanovich CJP. The effects of sodium fluoride on calcium metabolism of subjects with metabolic bone diseases. J Clin Invest. 1964;43:545-56. CrossrefMedlineGoogle Scholar4. EriksenHodgsonRiggs ESB. Treatment of osteoporosis with sodium fluoride. In: Riggs BL, Melton LJ III, eds. Osteoporosis. New York: Raven Press, 1988:415-32. Google Scholar5. J Bone Mineral Res. 1989;4(Suppl 2): [In press]. Google Scholar6. BattistaFletcher RS. Making recommendations on preventive practices: methodological issues. Am J Prev Med. 1988;4:53-76. MedlineGoogle Scholar7. MamelleMeunierDusan NPR. Risk-benefit ratio of sodium fluoride treatment in primary vertebral osteoporosis. Lancet. 1988;2:361-5. CrossrefMedlineGoogle Scholar8. GutteridgePriceNicholson DRG. Fluoride in osteoporotic vertebral fractures-trabecular increase, vertebral fractures, femoral fractures. In: Christiansen C, Arnaud CD, Nordin BE, Parfitt AM, Peck WA, Riggs BL, eds. Osteoporosis 2. Copenhagen, Denmark: Aalborg Stifsbogtrykkeri; 1984:705-7. Google Scholar9. HedlundGallagher LJ. Increased incidence of hip fracture in osteoporotic women treated with sodium fluoride. J Bone Mineral Res. 1989;4:223-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From Creighton University, Omaha, Nebraska; Loma Linda University, Loma Linda, California; Indiana University, Indianapolis, Indiana; Mayo Clinic, Rochester, Minnesota; INSERM-U.234, Faculté Carrel, Lyon, France; University of Toronto, Toronto, Ontario; and Catholic University of Louvain, Brussels, Belgium. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTratamiento de la pérdida de masa ósea en la mujer postmenopáusicaComparative Safety of Bone Remodeling Agents with a Focus on Osteoporosis TherapiesFluoride Therapy for OsteoporosisMetabolic bone disease associated with total parenteral nutritionMonofluorophosphate Combined with Hormone Replacement Therapy Induces a Synergistic Effect on Bone Mass by Dissociating Bone Formation and Resorption in Postmenopausal Women: A Randomized Study1Bones and Crohnʼs: Problems and SolutionsFluoride Therapy of Established OsteoporosisEmerging Therapies for the Prevention or Treatment of Postmenopausal OsteoporosisAssociation of tibolone and fluoride displays a pronounced effect on bone mineral density in postmenopausal osteoporotic womenReductions in bone strength after fluoride treatment are not reflected in tissue-level acoustic measurementsIn corticosteroid-treated respiratory diseases, monofluorophosphate increases lumbar bone density: A double-masked randomized studyOsteoporotic fractures: background and prevention strategiesTherapy for Osteoporosis in MenFluoride therapy of type I osteoporosisEffects of resistance training on regional and total bone mineral density in premenopausal women: A randomized prospective studyOsteoporosis: Clinical Features, Prevention, and Treatmentosteoporosis, corticosteroids and inflammatory bowel diseaseMonofluorophosphate increases lumbar bone density in osteopenic patients: A double-masked randomized studySodium monofluorophosphate increases vertebral bone mineral density in patients with corticosteroid-induced osteoporosisEffects of fluoride on rat vertebral body biomechanical competence and bone massA biopharmaceutic approach in designing a controlled release tablet of sodium monofluorophosphate: 1.in vitro andin vivo studies in beagle dogsMarked decrease in trabecular bone quality after five years of sodium fluoride therapy; assessed by biomechanical testing of iliac crest bone biopsies in osteoporotic patientsSPECIFIC DIETARY INTERVENTIONSClinical trial of fluoride therapy in postmenopausal osteoporotic women: Extended observations and additional analysisTreatment of Vertebral Osteoporosis with Fluoride SaltsDie Makro- und MikroStruktur des Knochens bei FluoroseFluoride increases net45Ca uptake by SaOS-2 cells: The effect is phosphate dependentGlucocorticoid-induced osteoporosis: pathogenesis, prevention and treatment, with special regard to the rheumatic diseasesOsteoporosis and Hip FractureEstrogen replacement therapy in women at increased risk for breast cancerThe effect of treatment with calcitonin on vertebral fracture rate in osteoporosis8 Osteoporosis: pathogenesis, diagnosis, prevention and managementSpinal fractures during fluoride therapy for osteoporosis: Relationship to spinal bone densitySodium fluoride prevents bone loss in primary biliary cirrhosisEffect of sodium fluoride on bone density in chickensTreatment of osteoporosis with sodium fluoride or parathyroid hormoneSide-effects of fluoride therapyRheumatic syndromes caused by antirheumatic drugsFluoride treatment in osteoporosis.How do we know what we know? The randomized controlled trial revisitedFluoride therapy in postmenopausal osteopenic women: Effect on vertebral and femoral bone density and prediction of bone responseToward a cure for osteoporosis: Reversal of excessive bone fragilityFluoride therapy for osteoporosis: A review of dose response, duration of treatment, and skeletal sites of actionCan the adult skeleton recover lost bone?Chapter 21. Recent Advances in Bone Metabolism and Osteoporosis ResearchPhysiological and Pharmacological Regulation of Biological CalcificationEvaluating the impact of municipal water fluoridation on the aquatic environment.Intermittent Cyclical Etidronate Treatment of Postmenopausal OsteoporosisFluoride treatment for osteoporosisFluoride treatment for osteoporosisEffect of Fluoride Treatment on the Fracture Rate in Postmenopausal Women with Osteoporosis“Osteoporosis”: Etiologies, prevention, and treatment 15 October 1989Volume 111, Issue 8Page: 678-680KeywordsArthritisIntoxicationSafetySafety studies Issue Published: 15 October 1989 PDF downloadLoading ...