tbuckley/cabot-search huggingface dataset:
Relationship between serum ferritin and total body iron stores in idiopathic haemochromatosis.
Authors: L W Powell, J W Halliday, J L Cowlishaw
Journal: Gut (1978)

The relationship between the serum ferritin concentration and total body iron stores was investigated in 41 patients with idiopathic haemochromatosis and 199 first or second degree relatives. Thirty-two relatives (16.1%) had increased iron stores and serum ferritin levels were increased in all but one of them. The false-positive rate in the relatives with normal iron stores was 1.8% compared with 10% for the serum iron concentration and 33% for the transferrin saturation. There was a significant correlation between the serum ferritin concentration and both the chelatable body iron and the hepatic iron concentration. We conclude that in the natural history of classical idiopathic haemochromatosis the serum ferritin concentration is usually raised when hepatic iron stores are increased and before there is architectural damage to the liver.
Guidelines: Community Support Vital to Promote Cancer-Preventing Lifestyle
Authors: Bridget M. Kuehn
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aspergillus fumigatus can Induce MUC5AC Expression via Epidermal Growth Factor Receptor in the Airway Epithelial Cells (NCI-H292)
Authors: T. Oguma, K. Asano, M. Kodama, N. Horiuchi, R. Yanagisawa, S. Ueda, T. Takihara, J. Kagyo, M. Wakaki, K. Fukunaga, K. Sayama, A. Ishizaka
Journal: Journal of Allergy and Clinical Immunology (2008)
Measurement of Endogenous Nitric Oxide in the Lungs of Patients with the Acute Respiratory Distress Syndrome
Authors: STEPHEN J. BRETT, TIMOTHY W. EVANS
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Elevated levels of nitric oxide (NO) are detectable in the exhaled breath of patients suffering from a number of inflammatory lung diseases. We hypothesized that NO would be detectable in the exhaled air of patients with the acute respiratory distress syndrome (ARDS) undergoing mechanical ventilation and that the concentration would be greater than that from a control group of ventilated subjects. The concentration of NO in the lower airways of 13 patients with ARDS and 18 patients anesthetized and ventilated prior to cardiac surgery was measured by chemiluminescence. The NO concentration was 1.13 ± 0.36 (mean ± SEM) parts per billion (ppb) in the ARDS group and 5.5 ± 0.8 ppb in the control group (2 p < 0.0001). NO is detectable in the exhaled air of patients with ARDS and is at a lower concentration than in control subjects.
EXCISION OF THE TONGUE FOR CARCINOMA.
Authors: C. E. RUTH
Journal: JAMA (1907)

The great number of methods for excision of the tongue gives abundant testimony of the unsatisfactory state in which the various procedures are held by the profession and justifies me in presenting the following plan, which has proved perfectly satisfactory in my hands. It enables the total removal to be made without preliminary tracheotomy, without any annoyance whatever from hemorrhage, without danger, and assures a rapid and an easy convalescence while giving the maximum protection against recurrence. In every case which can with certainty be diagnosed as carcinoma of the tongue accompanied by infiltration the lymph nodes in line with the lymph current are already involved. The removal of these glands is as important as the removal of the primary growth and should be done in all operable cases. The first step, therefore, should be the making of an incision under the lower jaw from behind one carotid bifurcation to
Oxidized Phospholipids Are Present on Plasminogen, Affect Fibrinolysis, and Increase Following Acute Myocardial Infarction
Authors: Gregor Leibundgut, Kiyohito Arai, Alexina Orsoni, Huiyong Yin, Corey Scipione, Elizabeth R. Miller, Marlys L. Koschinsky, M. John Chapman, Joseph L. Witztum, Sotirios Tsimikas
Journal: Journal of the American College of Cardiology (2012)
Better lungs for better legs: novel bronchodilator effects in COPD
Authors: P. Calverley
Journal: Thorax (2010)

Limitation of exercise capacity plays a central role in the life of the patient with chronic obstructive pulmonary disease (COPD), both as a marker of well-being1 and as an indicator of a poor prognosis.2 Our ability to characterise this crucial aspect of disease has grown rapidly in the last decade and with this so has our understanding of the many complex reasons for exercise impairment. It has long been recognised that the maximum ventilation during exercise is related to the initial FEV1 (forced expiratory volume in 1 s), with several formulae being developed to predict this. It was accepted that an inability to sustain a high level of ventilation would limit exercise performance in COPD, although exactly why this happened was uncertain. In the last decade there has been compelling evidence that changes in the operating lung volumes during exercise lead to mechanical limitation of inspiration and hence of tidal volume, which is associated with the sensation of breathlessness.3 4 Dynamic hyperinflation is a very consistent finding in COPD and can even occur early in the natural history of COPD, at least in symptomatic people.5 However, not all patients are limited exclusively by breathlessness on exertion, and data from the McMaster group in the 1990s pointed out that many patients were limited by a feeling of heaviness or fatigue in their legs, either along with breathlessness or dominating this sensation.6 As a result, attention began to turn to other factors, such as co-morbid cardiac disease and the possibility that skeletal muscle itself was not normal in COPD.7

One way of exploring …
Characterization of Specific Antibody Deficiency in Adults with Medically Refractory Chronic Rhinosinusitis
Authors: T.F. Carr, A.P. Koterba, R. Chandra, L.C. Grammer, D.B. Conley, K.E. Harris, R. Kern, R.P. Schleimer, A. Tripathi-Peters
Journal: Journal of Allergy and Clinical Immunology (2011)
Peptidyl-Glycine α-Amidating Monooxygenase Targeting and Shaping of Atrial Secretory Vesicles
Authors: Vénus Labrador, Cécile Brun, Stéphane König, Angela Roatti, Alex J. Baertschi
Journal: Circulation Research (2004)

ANP (atrial natriuretic peptide) is widely recognized as an important vasorelaxant, diuretic, and cardioprotective hormone. Little is known, however, about how ANP-secretory vesicles form within the atrial myocytes. Secretory vesicles were visualized by fluorescence microscope imaging in live rat atrial myocytes expressing proANP-enhanced green fluorescent protein (EGFP), or N-terminal-mutated fusion proteins thought to suppress the calcium-dependent aggregation of proANP. Results showed the following: (1) aggregates of proANP and coexpressed proANP-EGFP recruited peptidylglycine alpha-amidating monooxygenase (PAM)-1, an abundant atrial integral vesicle membrane protein; (2) coexpressed N-terminal-mutated (Glu23,24-->Gln23,24) and N-terminal-deleted proANP-EGFP inhibited recruitment of PAM-1 by up to 60%; (3) 4-phenyl-3-butenoic acid (PBA) (10 mumol/L), a pharmacological inhibitor of the lumenal peptidylglycine alpha-hydroxylating monooxygenase domain of PAM proteins, inhibited recruitment of endogenous PAM-1 and of coexpressed pro-EGFP-PAM-1; (4) PBA had no effect on exocytosis of the potassium inward rectifier KIR2.1; (5) PBA induced a deformation of the secretory vesicles but did not inhibit docking. These findings suggest that recruitment of PAM-1 to secretory vesicles depends on intact N-terminal proANP and on the lumenal domain of PAM-1. Conversely, PAM-1 participates in shaping the proANP-secretory vesicles. The full text of this article is available online at http://circres.ahajournals.org.
EARLY DIAGNOSIS AND OPERATIVE TREATMENT OF GASTRIC CANCER.
Authors: G. W. McCASKEY
Journal: JAMA (1905)

minutes after they have been noted.Dr. Osier also empha¬ sized the need for the prompt co-operation of the surgeon.In general hospital cases there is not time to call the attending surgeon and, therefore, when the case has been carefully stud¬ ied and diagnosis of perforation made, the house surgeon should immediately operate.The last case at the Johns Hop¬ kins Hospital, he said, illustrates the importance of this.A strong, robust German, in the tenth or eleventh day of the disease, at 12 o'clock was suddenly seized with pain in the abdomen.He was seen by Dr. McCrae and was also carefully watched by the resident surgeon.He was operated on at 3 o'clock.The interesting thing was that the operation seemed to make no difference in the progress of the case.The per¬ foration was found, was fixed and the patient made an un¬ eventful recovery from a very severe attack of typhoid fever.The records of 19 eases with perforation that were operated on show that 7 recovered, which is an average of 33 per cent, and is as good as can be expected in a general hospital where the very severe cases are received, sometimes even with per- forative peritonitis.Dr. J. C. Wilson, Philadelphia, said that one of the rules that he gives the resident physicians, particularly in the German and Pennsylvania hospitals, is to ascertain the con¬ ditions as regards rigidity as a mater of routine at every visit.The mere suspicion of rigidity of the right side, at the right lower quadrant of the rectus muscle, requires a report at once to the general physician.Pain, particularly if with rigidity, should make the physician notify the surgeon to come prepared to operate, and the patient should be made ready to go to the operating room without waiting for the coming of the surgeon.That is one of the most important points re¬ garding the routine management of enteric fever from the standpoint of early diagnosis of perforation.On the other hand, said Dr. Wilson, in several cases sudden intense pain occurred on the right side of the abdomen, in the iliac region, with rigidity of muscles, but with very little constitutional disturbance; in a few hours these symptoms passed away and the patient was left apparently as well as previously.There was no perforation and he was at a loss to account for it.Dr. Wilson is strongly of the opinion that hemorrhage and perforation very rarely occur at the same time, but he thinks that hemorrhage is not rarely a precursor of perforation and, therefore, that a vigilant watching is very necessary.The time has come for the profession seriously to consider opening the abdomen to stop the bleeding.Dr. Morris Manges, New York, agreed with Dr. Osier's points and said that the whole trouble of diagnosis in typhoid perforation in the early stages is that the general practitioner wants too much for diagnosis.
The Care of the Psychiatrically Disturbed Elderly Patient in the Community
Authors: COLIN F. LIPSCOMB
Journal: American Journal of Psychiatry (1971)

A study was made of elderly psychiatrically disturbed patients referred to the Yorkton Psychiatric Centre over a two-year period. The great majority of these patients were able to return home or to the care of their relatives following treatment. The author discusses the results with specific reference to the implications they may have for the general problem of psychiatric care for the aged.
Mechanism of postarrhythmic renal vasoconstriction in the anesthetized dog.
Authors: R E Katholi, S Oparil, F Urthaler, T N James
Journal: Journal of Clinical Investigation (1979)

The mechanism of postarrhythmic renal vasoconstriction was studied in 28 dogs anesthetized with pentobarbital sodium (30 mg/kg i.v.). Rapid atrial or ventricular pacing or induction of atrial fibrilation were used to produce at least 20% prompt decrease in cardiac output and mean arterial blood pressure. Return to control cardiac output and blood pressure occurred within 3 minutes after cessation of the arrhythmia, but renal blood flow remained significantly decreased (26%) with gradual recovery by 17.7 +/- 6.6 min. Infusion of phentolamine (0.25 mg/min) into the renal artery, intravenous hexamethonium (l mg/kg), adrenal demedullation, or cooling the cervical vagi prevented postarrhythmic renal vasoconstriction. In contrast, renal denervation, intravenous bretylium (10 mg/kg), intravenous atropine (0.5 mg/kg) or intrarenal SQ 20881 (0.20 mg/min) has no effect on postarrhythmic renal vasoconstriction. Intravenous propranolol (0.5 mg/kg) intensified postarrhythmic renal vasoconstriction. These data suggested that the postarrhythmic renal vasoconstrictive response required intact vagi and was due to alpha adrenergic stimulation by adrenal catecholamines. However, femoral arterial catecholamine levels were not elevated above control during postarrhythmic renal vasoconstriction. We therefore sought local vascular pathways by which catecholamines might reach the kidneys. An adrenorenal vascular network was found in each dog. Collection of catecholamines from these vessels during postarrhythmic renal vasoconstriction in six dogs revealed catecholamine concentrations threefold higher than simultaneously collected femoral arterial catecholamines levels. Because ligation of these vessels abolished postarrhythmic renal vasoconstriction in each dog, we conclude that postarrhythmic renal vasconstriction is due to adrenal catecholamines reaching the kidneys through an adreno-renal vascular network and that the response requires intact vagi.
Elevation of Inferior Vena Cava Pressure and Thoracic Lymph and Urine Flow
Authors: YALE J. KATZ, A. T. K. COCKETT, RAYMOND.S MOOR
Journal: Circulation Research (1959)

With an increase in renal vein pressure by partial obstruction of the inferior vena cava in dogs, there follows an increase in thoracic lymph flow and a simultaneous decrease in urine flow and urine sodium excretion per minute. The increase in lymph flow appears to be caused by an increased production of renal lymph, since control animals with absent or nonfunctioning kidneys fail to show this lymph flow increase. Renal deviation of fluid and sodium to the lymphatics may similarly occur in heart failure and account for the retention of sodium and water.
Utility of ViraPapRemains To Be Established
Authors: J. Corliss
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Utility of ViraPapRemains To Be Established Get access Julie Corliss Julie Corliss Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 4, 21 February 1990, Pages 252–253, https://doi.org/10.1093/jnci/82.4.252 Published: 21 February 1990
Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function
Authors: Jan Kubach, Petra Lutter, Tobias Bopp, Sabine Stoll, Christian Becker, Eva Huter, Christoph Richter, Petra Weingarten, Tobias Warger, Jürgen Knop, Stefan Müllner, John Wijdenes, Hansjörg Schild, Edgar Schmitt, Helmut Jonuleit
Journal: Blood (2007)
Gene induction studies and toxicity of chemical mixtures.
Authors: M M Mumtaz, D B Tully, H A El-Masri, C T De Rosa
Journal: Environmental Health Perspectives (2002)

As part of its mixtures program, the Agency for Toxic Substances and Disease Registry (ATSDR) supports in vitro and limited in vivo toxicity testing to further our understanding of the toxicity and health effects of chemical mixtures. There are increasing concerns that environmental chemicals adversely affect the health of humans and wildlife. These concerns have been augmented by the realization that exposure to chemicals often occurs to mixtures of these chemicals that may exhibit complex synergistic or antagonistic interactions. To address such concerns, we have conducted two studies with techniques that are being used increasingly in experimental toxicology. In the first study, six organochlorine pesticides (4,4 -DDT, 4,4 -DDD, 4,4 -DDE, aldrin, dieldrin, or endrin) were selected from the ATSDR Comprehensive Environmental Response, Compensation and Liability Act of 1980 (or Superfund) priority list and tested for their ability to modulate transcriptional activation of an estrogen-responsive reporter gene in transfected HeLa cells. In these assays, HeLa cells cotransfected with an expression vector encoding estrogen receptor and an estrogen-responsive chloramphenicol acetyltransferase (CAT) reporter plasmid were dosed with and without selected environmental chemicals either individually or in defined combinations. Estradiol consistently elicited 10- to 23-fold dose-dependent inductions in this assay. By contrast, all six of the organochlorine pesticides showed no detectable dose-related response when tested either individually or in binary combinations. Thus, these chemicals as binary mixtures do not exhibit any additional estrogenicity at the levels tested in these assays. In the second study, arsenic [As(V)], cadmium [Cd(II)], chromium [Cr(III, VI)], and lead [Pb(II)] were tested in a commercially developed assay system, CAT-Tox (L), to identify metal-responsive promoters and to determine whether the pattern of gene expression changed with a mixture of these metals. This assay employs a battery of recombinant HepG2 cell lines to test the transcriptional activation capacity of xenobiotics in any of 13 different signal-transduction pathways. Singly, As(V), Cd(II), Cr(III, VI), and Pb(II) produced complex induction profiles in these assays. However, no evidence of synergistic activity was detected with a mixture of Cd(II), Cr(III), and Pb(II). These results have shown metal activation of gene expression through several previously unreported signal-transduction pathways and thus suggest new directions for future studies into their biochemical mechanisms of toxicity. In conclusion, the (italic)in vitro(/italic) methods used in these studies provide insights into complex interactions that occur in cellular systems and could be used to identify biomarkers of exposure to other environmental chemical mixtures.
The Aetiology and Pathology of Sporadic Puerperal Septicaemia
Authors: W. Strange
Journal: BMJ (1883)

The urine was scanty, varying from eleven to twenty-one ounces; it contained two-thirds of albumen and 166.5 grains of urea.The diarrhoea doubtless was the cause of the diminished quantity of urine.Nscroysy, October 4th, 1881.The body was very emaciated.The lower half of the ileum, and the whole of the large intestine, were occupied by extensive ulcers of well-marked tubercular form.The spleen (11 ounces) contained numerous sago-bodies, and some tubercle, as well as lardaceous material.The liver (3 lbs. 7oz.) was apparently lardaceous.The kidneys (10 ounces) showed a wide cortex, and were markedly lardaceous.The lungs had large cavities at the apices, with foul contents, each cavity being of the size of an orange.The left lung also had a cavity in the axillary region.The lower lobes of both lungs contained caseous tubercle and purulent infiltration.The larynx was ulcerated.RjcnAxIs.-This was undoubtedly a case of lardaceous disease following on the exhausting discharge of expectoration and diar- rhoea.As it came under notice only shortly before death, the ob- servations taken were few; but, as far as they went, they indicated the presence of moderate temperatures where, considering the ex- tensive ulcerative processes, we should have expected high pyrexial ones.The quantity of urine and urea excreted was decidedly small; this may have been due to the profuse diarrhcea.CASE Ix.-James R., aged 27, was admitted May 14th, 1878.He had cough and yellow expectoration, occasionally streaked, fourteen months, caused by exposuLre to cold and wet, followed by night-sweats, and emaciation.Since November, 1877, he had shown rapid ema- ciation and loss of strength.His cough was troublesome; expectoration was yellow, and copious.The tongue was furred.In the right chest, tubular sounds and crepitation, were heard in the first interspace.In left chest, undue resonance and cracked-pot sound were heard, with distant cavernous breathing from the clavicle to the fifth rib.Crepitation was audible over the lower thirdl.There was dulness above the scapula.Temperature-observations were taken nine days after a(Imission, in consequence of rigors coming on and occurring daily, generally about 11 A.M., accompaniedl by a quick pulse (110 to 120), and hurried respiration.Vomiting occurred generally after breakfast for a week.Later on night-sweats appeared, and the rigors ceased.On June 20th, he complained of pain in the back; slight cedema of the legs was noted, and the urine was examined, and found to contain albumen occupying one-third of the test-tube.The temperature-averages of twenty-seven days were: at 8 A.M.
Bipolar disorder evolved as an adaptation to severe climate
Authors: Julia A. Sherman
Journal: Behavioral and Brain Sciences (2006)

Keller &amp; Miller (K&amp;M) assert that mental disorders could not have evolved as adaptations, but they fail to make their case against the theory of the evolutionary origin of bipolar disorder that I have proposed (Sherman 2001). Such an idea may be unorthodox, but it has considerable explanatory power and heuristic value.
Tobacco Smolders on
Authors: Jerome S. Brody
Journal: New England Journal of Medicine (1978)

With the report of "Smokers' Polycythemia" by Smith and Landaw in this issue of the Journal (page 6) the list of physiologic abnormalities associated with cigarette smoking grows. The authors argue convincingly that the elevated carboxyhemoglobin levels seen in their group of 22 polycythemic smokers were responsible for serious tissue hypoxia. They suggest that the hypoxia resulted not only from the functional anemia produced by carbon monoxide binding of hemoglobin, but also from a shift in the oxyhemoglobin curve of the remaining hemoglobin unbound by carbon monoxide. An additional factor contributing to their patients' polycythemia was an unexplained decrease in . . .
Empyema of the Antrum in a Child Aged 8 Weeks
Authors: D. Power
Journal: BMJ (1897)

ance of throat disease in teachers working under such conditions, and the comparative immunity of those not so circumstanced; (b) the history of certain cases in which the incep- tion of the throat lesion could be traced; and (c) the state- ments of experienced teachers themselves.It seemed prob- able, also, that the other influences mentioned above co- operated to produce laryngeal or pharyxigeal disease.
Granulomatous angiitis leading to a pulmonary veno-occlusive disease-like picture
Authors: N. Dwyer, R. Smith, D. Challis, D. Reid, D. Kilpatrick
Journal: European Respiratory Journal (2009)

Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary hypertension characterised by extensive fibrotic occlusion of pulmonary veins. PVOD has a similar insidious presentation to idiopathic pulmonary arterial hypertension but responds poorly to conventional therapies and has a worse prognosis. The current study reports the case of a Caucasian female with a long history of progressive dyspnoea ultimately diagnosed as focal granulomatous venulitis leading to a pulmonary veno-occlusive disease-like pathology. The present study highlights the challenges in diagnosing and treating this condition.