tbuckley/cabot-search huggingface dataset:
Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs
Authors: Manikandan Subramanian, Edward Thorp, Goran K. Hansson, Ira Tabas
Journal: Journal of Clinical Investigation (2012)

TLR activation on CD11c+ DCs triggers DC maturation, which is critical for T cell activation. Given the expansion of CD11c+ DCs during the progression of atherosclerosis and the key role of T cell activation in atherogenesis, we sought to understand the role of TLR signaling in CD11c+ DCs in atherosclerosis. To this end, we used a mouse model in which a key TLR adaptor involved in DC maturation, MYD88, is deleted in CD11c+ DCs. We transplanted bone marrow containing Myd88-deficient CD11c+ DCs into Western diet–fed LDL receptor knockout mice and found that the transplanted mice had decreased activation of effector T cells in the periphery as well as decreased infiltration of both effector T cells and Tregs in atherosclerotic lesions. Surprisingly, the net effect was an increase in atherosclerotic lesion size due to an increase in the content of myeloid-derived inflammatory cells. The mechanism involves increased lesional monocyte recruitment associated with loss of Treg-mediated suppression of MCP-1. Thus, the dominant effect of MYD88 signaling in CD11c+ DCs in the setting of atherosclerosis is to promote the development of atheroprotective Tregs. In the absence of MYD88 signaling in CD11c+ DCs, the loss of this protective Treg response trumps the loss of proatherogenic T effector cell activation.
In vivo cellular imaging pinpoints the role of reactive oxygen species in the early steps of adult hematopoietic reconstitution
Authors: Daniel Lewandowski, Vilma Barroca, Frédéric Ducongé, Jan Bayer, Jeanne Tran Van Nhieu, Carine Pestourie, Pierre Fouchet, Bertrand Tavitian, Paul-Henri Roméo
Journal: Blood (2009)

Few techniques are available to characterize in vivo the early cellular dynamics of long-term reconstitution of hematopoiesis after transplantation of hematopoietic stem cells (HSCs) after lethal irradiation. Using a fiber-optic imaging system, we track the early steps of in vivo recruitment and proliferation of Lin(-)Sca-1(+)c-Kit(+)CD34(-) (LSKCD34(-)) HSCs highly enriched in HSCs and transplanted into lethally irradiated mice. Recruitment of the transplanted LSKCD34(-) hematopoietic cells first occurs in the femoral head and is continuous during 24 hours. Quantification of the fluorescence emitted by the transplanted hematopoietic cells shows that proliferation of LSKCD34(-) hematopoietic cells in the femoral head was potent 3 days after transplantation. Using a development of this fiber-optic imaging system, we show that the transplanted LSKCD34(-) hematopoietic cells are associated with vascularized structures as early as 5 hours after transplantation. This early association is dependent on reactive oxygen species (ROS) partly through the regulation of vascular cell adhesion molecule-1 expression on endothelial cells and is followed by a ROS-dependent proliferation of LSKCD34(-) hematopoietic cells. This new in vivo imaging technique permits the observation of the early steps of hematopoietic reconstitution by HSCs in long bones and shows a new role of ROS in the recruitment of HSCs by bone marrow endothelial cells.
Computer-Based Support Systems for Women With Breast Cancer
Authors: Kazim Sheikh
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal Abnormality in the Nail-Patella Syndrome.
Authors: Pauline Bazinet
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Renal Abnormality in the Nail-Patella Syndrome.Pauline Bazinet, M.D., Paul Krasner, M.D., Serge Duckett, M.D., Norman Lasker, M.D., F.A.C.P.Pauline Bazinet, M.D.Search for more papers by this author, Paul Krasner, M.D.Search for more papers by this author, Serge Duckett, M.D.Search for more papers by this author, Norman Lasker, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-804_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRenal involvement in osteo-onychodysplasia (nail-patella syndrome) has been well delineated. A family consisting of the father and his three daughters was investigated. The father presented with renal insufficiency (creatinine clearance, 10 ml/min) and proteinuria; the daughters were found to have 0 to 1 + proteinuria with normal creatinine clearance. Inulin and para-amino hippuric acid clearances were normal in the three daughters, whereas all showed a concentration defect with normal urinary acidification.No abnormality could be found in amino acid excretion, but 24-hr urine levels of hydroxyproline were elevated. Findings on light microscopy in the early stages included local proliferative changes... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFamilial bilateral antecubital pterygia with severe renal involvement in nail-patella syndromeGenetic counselling in hereditary osteo-onychodysplasia (HOOD, nail-patella syndrome) with nephropathy.The nephropathy of the nail-patella syndrome 1 May 1970Volume 72, Issue 5Page: 804-804KeywordsAmino acidsAttentionCreatinineExcretionLight microscopyProteinuriaUrine Issue Published: 1 May 1970 PDF DownloadLoading ...
Detection of the Adrenal Glands by Endoscopic or Transabdominal Ultrasound
Authors: C. F. Dietrich, T. Wehrmann, C. Hoffmann, G. Herrmann, W. F. Caspary, H. Seifert
Journal: Endoscopy (1997)

Background and Study Aims: The value of transabdominal and endoscopic ultrasound (EUS) in detecting normal adrenal glands is not yet established. The aim of our study was to evaluate whether these techniques can be routinely used to visualize the adrenal glands in patients without suspected adrenal pathology.
Human Granulocytic Ehrlichiosis: A Cardiac Risk Factor?
Authors: Maria E. Aguero-Rosenfeld
Journal: Annals of Internal Medicine (1997)

Letters1 July 1997Human Granulocytic Ehrlichiosis: A Cardiac Risk Factor?Maria E. Aguero-Rosenfeld, MD, Gary P. Wormser, MD, and J. Stephen Dumler, MDMaria E. Aguero-Rosenfeld, MDNew York Medical College; Valhalla, NY 10595Johns Hopkins Medical Institutions; Baltimore, MD 21287Search for more papers by this author, Gary P. Wormser, MDNew York Medical College; Valhalla, NY 10595Johns Hopkins Medical Institutions; Baltimore, MD 21287Search for more papers by this author, and J. Stephen Dumler, MDNew York Medical College; Valhalla, NY 10595Johns Hopkins Medical Institutions; Baltimore, MD 21287Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-1-199707010-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Dr. Jorde that the patients in our case series were less ill than those described in the midwestern United States [1]. Few of our patients had comorbid conditions, and our patients were significantly younger than those in the Midwest cohort (47 ± 16 years compared with 57 ± 20 years; P = 0.04). Other factors that might account for differences in illness severity, such as referral bias or infection with less virulent strains of Ehrlichia, cannot be excluded.It is somewhat misleading, however, to regard our experience with human granulocytic ehrlichiosis as “benign.” Five patients ...References1. Bakken JS, Dumler JS, Chen SM, Eckman MR, Van Etta LL, Walker DH. Human granulocytic ehrlichiosis in the upper Midwest United States. JAMA. 1994; 272:212-8. Google Scholar2. Hardalo CJ, Quagliarello V, Dumler JS. Human granulocytic ehrlichiosis in Connecticut: report of a fatal case. Clin Infect Dis. 1995; 21:910-4. Google Scholar3. Goodman JL, Nelson C, Vitale B, Madigan JE, Dumler JS, Kurtti TJ, et al. Direct cultivation of the causative agent of human granulocytic ehrlichiosis. N Engl J Med. 1996; 334:209-15. Google Scholar4. Williams JD, Snow RM, Arciniegas JG. Myocardial involvement in a patient with human ehrlichiosis. Am J Med. 1995; 98:414-5. Google Scholar Author, Article, and Disclosure InformationAffiliations: New York Medical College; Valhalla, NY 10595Johns Hopkins Medical Institutions; Baltimore, MD 21287 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1997Volume 127, Issue 1Page: 90KeywordsAntibodiesCoronary arteriesEhrlichiaEhrlichiosisHeart diseasesInfectious diseasesInflammationMyocarditisThoraxTicks Issue Published: 1 July 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cost of Antibiotics
Authors: Steven E. Schonberg
Journal: JAMA (1983)

<h3>To the Editor.—</h3> The article by Shapiro et al, "Benefit-Cost Analysis of Antimicrobial Prophylaxis in Abdominal and Vaginal Hysterectomy" (1983;249:1290), was funded by the manufacturer of a drug known as cefazolin sodium and concluded that short courses of this particular substance given prophylactically would be useful in reducing hospital costs. The reported article is potentially defective in regard to the definition of "morbidity." The extraordinarily high morbidity that was described for patients who had had a hysterectomy must have been the result of the definition. Greater than 40% of the patients who had had a hysterectomy included in the study were said to have morbidity. The fact that a fever of two days' duration would be considered morbidity for the purposes of the study was probably the cause of the unusually high stated morbidity. I would suggest that a manufacturer of acetaminophen support a similar study to determine whether its
Ventricular performance and energy of compression, power, and rate of change of power during isovolumic contraction
Authors: P. D. STEIN, G. G. MCBRIDE, H. N. SABBAH
Journal: Cardiovascular Research (1975)

During isovolumic contraction, there is a calculable compression of the blood within the ventricle. Energy is expended by the ventricle during isovolumic contraction, and some of it is transferred to the blood in the form of elastic compression. The rate of energy transfer (power) and acceleration of energy transfer (rate of change of power) during isovolumic contraction were calculated based upon considerations of the energy of compression. In anaesthetized dogs, the isovolumic energy of compression was 42±6 (mean ± SE) dyn cm; peak isovolumic power was 1,400±300 dyn cm sec-1; and peak rate of change of power was 56,000± 15,000 dyn cm sec-2. During states of augmented contractility induced by isoproterenol, the peak acceleration of energy expenditure (peak rate of change of power) increased to 126,000 ± 33,000 dyn cm sec-2 (p<0·001). Conversely, with a reduction of contractility induced by propranolol, the peak isovolumic rate of change of power decreased to 30,000±5,700 dyn cm sec-2 (p<0·001). The peak rate of change of power was unaffected by changes of the afterload. A trend, however, suggests that it may be affected by preload. The derivations of the isovolumic energy of compression, power, and rate of change of power are based upon firm principles of fluid dynamics. No assumptions related to ventricular geometry, synergy of contraction, or characteristics of muscle fibres are implied. Because of its physiological meaning and the theoretical validity of its derivation, an expression such as the isovolumic peak rate of change of power, when utilized as an index of ventricular performance, would appear to be of value.
HMO's and the Cost of Medical Care
Authors: Joseph L. Dorsey
Journal: New England Journal of Medicine (1978)

Few subjects provoke as heated debate among practicing physicians as health-maintenance organizations (HMO's), especially the closed-panel medical group form of HMO. At a time when efforts to control the rate of increase in health-care expenditures nationally have become the central issue in public-policy deliberations on health care, the questions of whether and how HMO's achieve cost savings are of tremendous importance.An opinion frequently heard these days is that the alleged savings achieved by HMO's are illusory. Opponents of prepaid groups claim that HMO's keep their costs down by attempting to draw their enrollment from the younger and healthier segments . . .
MIKULICZ'S DISEASE AND DIABETES
Authors: HENRY J. JOHN
Journal: JAMA (1933)

During the past decade, a number of European investigators have been interested in studying the parotid glands. Many clinical observations have been made, and considerable experimental work has been done in an effort to learn the true function and significance of the salivary glands. In spite of the tremendous amount of work that has been done on this problem, the question as to whether or not the salivary glands have an internal secretion has not yet been answered satisfactorily. Considerable clinical and experimental evidence has accrued to indicate that there probably is an indirect if not a direct relationship between the salivary glands and the glands of internal secretion. That the parotid glands have a function in some way analogous or related to that of the pancreas has been suggested by recent clinical observations and experiments. Swelling of the parotid glands, or Mikulicz's disease, has been observed recently in a
Response of adrenomedullin system to cytokine in cardiac fibroblasts?role of adrenomedullin as an antifibrotic factor
Authors: T NISHIKIMI, K TADOKORO, K AKIMOTO, Y MORI, Y ISHIKAWA, K ISHIMURA, T HORIO, K KANGAWA, H MATSUOKA
Journal: Cardiovascular Research (2005)

Objective: The adrenomedullin system acts as an autocrine or paracrine factor (or both) in the development of cardiac hypertrophy and in the regulation of cardiac function. However, several aspects of the local action of adrenomedullin remain unclear. We studied the effects of interleukin 1-beta (IL-1β) on the adrenomedullin system in cardiac fibroblasts and also examined the pathophysiological significance of such effects.
Oxymetholone treatment in aplastic anaemia: changes in erythropoiesis and serum erythropoietin.
Authors: J A Napier, I Cavill, C D Dunn, A May, C Ricketts
Journal: BMJ (1976)

Oxymetholone treatment in aplastic anaemia: changes in erythropoiesis and serum erythropoietin This report describes how new techniques for measuring erythropoietin and erythropoietic function have been used to analyse the mode of action of oxymetholone during treatment of a patient with hypoplastic anaemia.
Prophylactic versus standby cardiopulmonary support for high risk percutaneous transluminal coronary angioplasty
Authors: Paul S. Teirstein, Robert A. Vogel, Gerald Dorros, Simon H. Stertzer, M.G. Vandormael, Sidney C. Smith, Paul A. Overlie, William W. O'Neill
Journal: Journal of the American College of Cardiology (1993)
Wisdom, technology, and the good life.
Authors: H T Markey
Journal: Environmental Health Perspectives (1979)

Wisdom lies in extraction of good from new and old. Wisdom alone produces a society of wise men unable to leave their caves. Technology alone produces a society ruled by cold, despotic facts. A proper combination of wisdom and technology can produce the good life. That requires recognition of our ambivalence toward technology, a move away from our superspecialization of technologists and nontechnologists and toward a clearer understanding of technology as a most important servant of man.
Measles Immunization
Authors: Georges Peter
Journal: JAMA (1991)

Generic recommendations for childhood immunization include guidelines for administration of vaccine to infants and children with febrile and minor illnesses. The most recent recommendations issued by the Immunization Practices Advisory Committee (ACIP) of the US Public Health Service state that "minor illnesses such as mild upper respiratory infections (URI) with or without low-grade fever are not contraindications for vaccination."<sup>1</sup>The ACIP further notes the importance of taking every opportunity to provide age-appropriate vaccinations, particularly "in persons whose compliance with medical care cannot be assured." The American Academy of Pediatrics gives similar recommendations.<sup>2</sup> Mild acute illness in some circumstances has been inappropriately considered a contraindication to vaccination. This misconception has contributed to missed opportunities to give measles vaccine to children who subsequently developed measles.<sup>3</sup>This and other missed opportunities to vaccinate children against measles at the recommended age have been incriminated as important factors in the occurrence of
A cross-over medication trial for patients with autosomal-dominant hypertension with brachydactyly
Authors: Herbert Schuster, Okan Toka, Hakan R. Toka, Andreas Busjahn, Özgür Öztekin, Thomas F. Wienker, Nihat Bilginturan, Sylvia Bähring, Falko Skrabal, Hermann Haller, Friedrich C. Luft
Journal: Kidney International (1998)
LEFT VENTRICULAR VOLUMES ESTIMATIONS USING A TOMOGRAPHIC COUNT BASED METHOD
Authors: L. Philippe, R. Itti, M. Brochier, I. Mena
Journal: Clinical Nuclear Medicine (1984)

Forty consecutive patients with coronary artery disease, myocardial infarction or valvular disease were evaluated by contrast ventriculography and gated blood pool emission tomography (GBPS). Left ventricular end-diastolic (EDV) and end-systolic volume (ESV) were assessed with both techniques. After tomographic reconstruction of the slices, transverse and sagittal images were obtained by addition of all ventricular 1 pixel thick slices in order to preserve the counts-blood volume relation. LV ROIs were determined using a threshold at 45% of maximum activity, while the stroke volume image defined the valvular planes. The position of the LV ROI centers of gravity were computed on each orthogonal plane. The activity of the center of gravity pixel on the transverse LV ROI represents the activity measured thru the thickness of the LV volume. The thickness is determined on an orthogonal slice (sagittal) at its center of gravity. The center of gravity of LV transverse ROI is assumed to correspond to the center of gravity of the LV sagittal ROI. The sum of counts in the transverse LV ROI was scaled by the value obtained for each of the pixels on the sagittal slice, and the same reverse processing was performed for sagittal volumes. Four volumes were computed for each patient (EDV transv., EDV sag., ESV transv., ESV sag.) and also mean (transv. sag.) EDV and ESV. The correlations between contrast single plane ventriculography and tomography are: r=.85 for transverse volumes, r=.87 for sagittal volumes and r=.88 for mean volumes (S.E.E. = 34.1 ml).
ABC of 1 to 7. The severely ill child.
Authors: H B Valman
Journal: BMJ (1982)

There is no precise definition of the severely ill child, but there are several conditions that need urgent treatment if he is to survive.In most cases the treatment will be started in the ambulance or the accident and emergency department.A glance at a child will show that he is desperately ill and that a rapid history and examination are needed.The time of onset and duration of the symptoms should be noted.Questions must include the presence of rash, occurrence of diarrhoea, vomiting, cough, or fast breathing.The child may be receiving drugs or have had access to tablets or household fluids.Recent loss of weight should be noted. ExaminationThe first priority is to ensure a clear airway and adequate ventilation and circulation.The child needs to be nursed on his side as vomiting and aspiration are constant hazards.A suction pump with a catheter of adequate bore-for example, FG 14-should be kept next to the patient and turned on before examination begins.If the child is not breathing spontaneously 100% oxygen should be given with a closely fitting mask and Ambu, Penlon, or similar inflating bag.The child may usually be ventilated satisfactorily by this method and intubation can wait until an anaesthetist or member of the paediatric unit arrives.If he is breathing spontaneously 100% oxygen should be given by rubber funnel or a mask if the child can tolerate it.Clinical signs of gross dehydration or a femoral pulse of poor volume indicates that the circulating blood volume is reduced and that intravenous fluids are required urgently.A low blood pressure indicates a severe reduction in plasma volume, but in children it is a late sign.Severe hypovolaemia may occur with no fall in the blood pressure.The child should be completely undressed and observed with good lighting.Diabetes mellitus Drowsiness after fit Head injury Poisons (including lead) Septicoemia with meningitis or osteomyelitis Gastroenteritis Continuous convulsions Upper airway obstruction Brnchopneumonia Bronchial asthma Bronchiolitis Paroxysmal tachycardia Pentonitis Urgent investigations