tbuckley/cabot-search huggingface dataset:
Acute Ischemic Vascular Events and Cisplatin
Authors: JAMES A. TALCOTT
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 July 1987Acute Ischemic Vascular Events and CisplatinJAMES A. TALCOTT, M.D., TERENCE S. HERMAN, M.D.JAMES A. TALCOTT, M.D.Search for more papers by this author, TERENCE S. HERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-1-121_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Doll and colleagues (1) recently reported acute ischemic vascular events after cisplatin-based chemotherapy in four young men with cancer of the testis. We report a case of myocardial infarction that occurred after radiation therapy and a different cisplatin-containing chemotherapy regimen in a young woman with lung cancer.A previously well 37-year-old nonsmoking women was hospitalized in March 1985, with a persistent cough. A medical evaluation showed bilateral supraclavicular adenopathy, a retrocardiac mass, and a lytic lesion in the L4 vertebral body. A supraclavicular lymph node biopsy specimen showed moderately well-differentiated squamous cell carcinoma consistent with a primary...References1. DOLLLISTGRECOHAINSWORTHHANDEJOHNSON DAFJKD. Acute vascular ischemic events after cisplatin-based combination chemotherapy for germ-cell tumors of the testis. Ann Intern Med. 1986;105:48-51. LinkGoogle Scholar2. HUFFSANDERS HE. Coronary artery occlusion after radiation. N Engl J Med. 1972;286:780. CrossrefMedlineGoogle Scholar3. SCHECHTERJONES JS. Myocardial infarction in a 27-year-old woman: possible complication of treatment with VP-16-213 (NSC-141540), mediastinal irradiation, or both. Cane Chemother Rep. 1975;59;887-8. MedlineGoogle Scholar4. BUCKNERRUDOLPHFEFER CRA. High-dose cyclophosphamide therapy for malignant disease: toxicity, tumor response, and the effects of stored autologous marrow. Cancer. 1972;29:357-65. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Dana-Farber Cancer Institute Joint Center for Radiation Therapy Boston, MA 02115 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHypertension in Cancer Patients and SurvivorsCardiac Complications in the Adult Bone Marrow Transplant PatientCardiac and cardiovascular toxicity of nonanthracycline anticancer drugsVascular Toxicity of Antineoplastic AgentsCardiotoxicity of Cancer TherapyProspective evaluation of major vascular events in patients with nonsmall cell lung carcinoma treated with cisplatin and gemcitabineCardiotoxicity of Cancer ChemotherapyCardiotoxicity of Chemotherapeutic AgentsAcute Coronary Events Following Cisplatin-Based Chemotherapy 1 July 1987Volume 107, Issue 1Page: 121-122KeywordsBiopsyChemotherapyLesionsLung and intrathoracic tumorsLymph nodesMyocardial infarctionRadiation therapySquamous cell carcinomaTesticular cancer Issue Published: 1 July 1987 PDF DownloadLoading ...
Periodic Lateralized Epileptiform Discharges
Authors: N Watemberg, L D Morton
Journal: New England Journal of Medicine (1996)

Figure 1. Electroencephalography in a 13-year-old boy with fever, altered sensorium, and sudden onset of seizures reveals complex repetitive discharges composed of spiky elements mixed with slower waveforms (Panel A). They are seen diffusely in the left (L) hemisphere (leads 1 to 8), occurring at intervals of approximately 2.5 seconds (arrows). The right (R) hemisphere (leads 11 to 18) shows abnormally slow background activity of 2 Hz per second (delta rhythm) compatible with the presence of acute encephalopathy. For comparison, an electroencephalogram obtained in a normal, awake subject is shown in Panel B. There is normal background activity of 11 . . .
Chronic Hepatitis B: A Critical Appraisal of Current Approaches to Therapy
Authors: Robert P. Perrillo, Robert G. Gish, Marion Peters, Emmet B. Keeffe, Alfredo Alberti, Maria Buti, W. Graham E. Cooksley, Michael W. Fried, Stephanos J. Hadziyannis, Yun–Fan Liaw
Journal: Clinical Gastroenterology and Hepatology (2006)
Survey of neonatal screening for primary hypothyroidism in England, Wales, and Northern Ireland 1982-4
Authors: D B Grant, I Smith
Journal: BMJ (1988)

National screening for congenital hypothyroidism was established in the United Kingdom in 1982. During 1982-4, 488 infants with primary congenital hypothyroidism were detected by the 25 regional screening laboratories in England, Wales, and Northern Ireland. In addition, one infant had signs of cretinism at birth and was investigated before the screening test was done and four infants were known to have been missed by the screening programme; among these four infants the initial thyroid stimulating hormone concentrations were normal in two with inherited defects of synthesis of thyroxine, not measured in one, and false negative in one. The overall incidence of primary hypothyroidism was 1:3937 births (boys 1:6640, girls 1:2756). The incidence seemed to be reduced in infants born to black mothers (two cases only) and increased in those born to Asian mothers (61 cases). Congenital anomalies other than those of the thyroid glands were reported in 36 children (7%), and 15 (3%) died from various causes before the age of 4. Infants who were considered to show unequivocal evidence of hypothyroidism started treatment at a median age of 17 days (5th and 95th centiles 10 and 42 days) compared with a median age of 14 days (5th and 95th centiles 9 and 21 days) for infants with classic phenylketonuria also detected by national screening.
Left Anterior Oblique View for Evaluation of Left Atrial Size
Authors: MURRAY G. BARON
Journal: Circulation (1971)

The left anterior oblique film of the chest provides a sensitive and accurate gauge of left atrial enlargement. The posterior wall of the atrium, which distends when the chamber enlarges, is seen in profile in this view. Dilatation of the left atrium is almost always reflected by this segment which assumes a convexly, curved contour. This finding is independent of most of the conditions that can alter the other roentgen signs of left atrial enlargement.
Treatment of vasospastic disease with prostaglandin E1.
Authors: P C Clifford, M F Martin, E J Sheddon, J D Kirby, R N Baird, P A Dieppe
Journal: BMJ (1980)

Prostaglandin E1, a vasodilator and potent inhibitor of platelet aggregation, was administered to 26 patients with severe vasospastic disease of the hands. Patients tolerated infusions well and reported appreciable symptomatic improvement. Five of eight ischaemic ulcers healed in six weeks. Non-invasive studies of blood flow were used to observe haemodynamic changes during and after infusions. The Doppler-derived radial artery pulsatility index fell from 8.8 +/- 0.6 to 4.6 +/0 0.5 (mean +/- SEM), indicating hand vasodilatation. This fall was maintained 24 hours after infusion (5.9 +/- 0.9), but the index had returned to normal values at two weeks. The amplitude of finger pulse volume recordings increased (5.6 +/- 0.7 mm to 23.8 +/- 3.4 mm) and was raised two and six weeks after infusion (13.5 +/- 2.1 mm). Hand temperature measured by infrared radiometry also increased (27.4 +/- 0.7 degrees C to 31.2 +/- 1.2 degrees C). Intensity of digital vasospasm induced by cold water challenge was not objectively affected by prostaglandin E1 despite an increased finger temperature after infusion. Nevertheless, patients reported less frequent and severe attacks. Prostaglandin E1 given by central venous infusion is a safe new vasoactive agent that can produce appreciable symptomatic improvement by increasing digital perfusion, which may last for several weeks after treatment. Further study will define its mode of action and its place in the management of peripheral vascular disease.
Role of IL-6 and Its Soluble Receptor in Induction of Chemokines and Leukocyte Recruitment
Authors: Maria Romano, Marina Sironi, Carlo Toniatti, Nadia Polentarutti, Paolo Fruscella, Pietro Ghezzi, Raffaella Faggioni, Walter Luini, Victor van Hinsbergh, Silvano Sozzani, Federico Bussolino, Valeria Poli, Gennaro Ciliberto, Alberto Mantovani
Journal: Immunity (1997)
Environmental aspects of injury and disease: liver and bile ducts
Authors: Edward S. Reynolds
Journal: Environmental Health Perspectives (1977)

Evolutionary processes have not yet developed specific and safe ways to detoxify all chemical species new to our environment. Indeed, some are transformed and/or conjugated by the liver into more toxic species. Environmental factors can modulate hepatic enzyme systems. Particularly responsive are the mixed function oxidases, which initiate the transformation of many xenobiotics to excretable species via reactions which generate electrophilic intermediates such as free radicals, epoxides and aldehydes. Unless these reactive metabolites are rapidly removed by subsequent detoxification reactions or by endogenous defense systems, destructive cytotoxic reactions can be triggered or cell constitutents “attacked” thereby causing either acute injury and/or more latent molecular injury to long chain biopolymers resulting in chromatin damage, or tumors. In vitro systems using purified, specialized cell fractions may be of considerable value in defining metabolic processes, but the results must be relevant to in vivo conditions. Although human liver is peculiarly resistant to tumorigenesis, liver microsomes (isolated endoplasmic reticulum) are extensively used as biological activators for in vitro mutagenicity test systems. The in vivo defense system of liver cells must be exceptionally efficient! Reactive metabolites generated in liver may be stable enough to migrate and cause injury to other tissues or organ systems. It is important to characterize metabolic pathways of toxic xenobiotics, subsequent molecular sites or modes of injury, and factors which depress or augment cellular defense systems including the biliary system responsible for the excretion of many xenobiotics. Only then can techniques or treatments be developed to screen individuals for risk to specific groups of xenobiotics, to protect those exposed, and to treat those injured.
Halothane and Liver Failure
Authors: Richard Aach
Journal: JAMA (1970)

Dr. John Bullock, Intern in Medicine, Jewish Hospital of St. Louis, and Assistant in Medicine, Washington University School of Medicine: A 62-year-old white woman was admitted to the surgical service on March 3, 1969, for an elective cholecystectomy. The patient was known to have had symptomatic gallstones since 1966. There was no prior history of liver disease, transfusions, excessive alcoholic intake, or exposure to individuals with jaundice or hepatotoxins. The day after admission the patient underwent cholecystectomy with halothane and nitrous oxide anesthesia. A 20-minute episode of hypotension occurred during the operative procedure at which time the blood pressure was less than 100/60 mm Hg and as low as 80/50 mm Hg. On the second postoperative day, in association with continuous coughing, wound dehiscence and colonic perforation occurred. Repair of the colonic perforation and colostomy were performed with the patient under spinal anesthesia and five minutes of halothane inhalation. Postoperatively,
1079 PURIFICATION OF LIVER PROGENITOR CELLS BY USING ALDEHYDE DEHYDROGENASE ACTIVITY
Authors: L. Dollé, J. Mei, C. Empsen, J. Best, E. Van Rossen, M. Najimi, S. Snykers, K. Streetz, E. Sokal, V. Rogiers, I.A. Leclercq, L. van Grunsven
Journal: Journal of Hepatology (2011)
Sharing patient information electronically throughout NHS: Patient confidentiality may not be guaranteed
Authors: P. D Oldfield
Journal: BMJ (2003)

Editor—As general practitioners in the brave new world of sharing patient information electronically throughout the NHS,1 can we still promise our patients that we will keep their secrets confidential? With the threat of central servers for our computers, practices would no longer be the keepers of their own data. The NHS would like easy access to our information—but who else would have such access?

If out of hours and accident and emergency departments are able to tap into our computers, then no one would have any medical secrets. Unlike hospitals, histories in general practice contain very deeply personal information about patients (mental illness, marital problems, alcoholism, abortions, impotence, etc). Does anyone really believe that it would remain secret for long that a local politician (or doctor) had been mentally ill?

Access for primary care trusts would mean that managers may be able to tap in and see the notes of their employees who are our patients. We will, of course, be promised that this will never happen. We may be promised that general practitioners can decide who has access and at what level, but for how long will the promise be kept when we don't own the equipment? Let no one tell me that lawyers and insurance companies will not hack in.

I believe that we should fight to retain control of our own data since confidentiality and trust are the cornerstones of general practice, and not an optional extra. The job is impossible without it, and if we lose this, then general practice is truly dead. Can I trust my computer?
Patient age at diagnosis is associated with the molecular characteristics of diffuse large B-cell lymphoma
Authors: Wolfram Klapper, Markus Kreuz, Christian W. Kohler, Birgit Burkhardt, Monika Szczepanowski, Itziar Salaverria, Michael Hummel, Markus Loeffler, Shoji Pellissery, Wilhelm Woessmann, Carsten Schwänen, Lorenz Trümper, Swen Wessendorf, Rainer Spang, Dirk Hasenclever, Reiner Siebert
Journal: Blood (2012)
Bicarbonate Does Not Improve Hemodynamics in Critically III Patients Who Have Lactic Acidosis
Authors: D J Cooper, K R Walley, B R Wiggs, J A Russell
Journal: Annals of Internal Medicine (1990)

Study Objective: To determine whether correction of acidemia using bicarbonate improves hemodynamics in patients who have lactic acidosis. Design: Prospective, randomized, blinded, crossover study. Each patient sequentially received sodium bicarbonate and equimolar sodium chloride. The order of the infusions was randomized. Setting: Intensive care unit of a tertiary care hospital. Patients: Fourteen patients who had metabolic acidosis (bicarbonate < 17 mmol/L and base excess < -10) and increased arterial lactate (mean, 7.8 mmol/L). All had pulmonary artery catheters and 13 were receiving catecholamines. Measurements and Main Results: Sodium bicarbonate (2 mmol/kg body weight over 15 minutes) increased arterial pH (7.22 to 7.36, P < 0.001), serum bicarbonate (12 to 18 mmol/L, P < 0.001), and partial pressure of CO2 in arterial blood (PaCO2) (35 to 40 mm Hg, P < 0.001) and decreased plasma ionized calcium (0.95 to 0.87 mmol/L, P < 0.001). Sodium bicarbonate and sodium chloride both transiently increased pulmonary capillary wedge pressure (15 to 17 mm Hg, and 14 to 17 mm Hg, P < 0.001) and cardiac output (18% and 16%, P < 0.01). The mean arterial pressure was unchanged. Hemodynamic responses to sodium bicarbonate and sodium chloride were the same. These data have more than 90% power of detecting a 0.5 L/min (7%) change in mean cardiac output after administration of sodium bicarbonate compared with that after sodium chloride. Even the 7 most acidemic patients (mean pH, 7.13; range, 6.90 to 7.20) had no significant hemodynamic changes after either infusion. Conclusions: Correction of acidemia using sodium bicarbonate does not improve hemodynamics in critically ill patients who have metabolic acidosis and increased blood lactate or the cardiovascular response to infused catecholamines in these patients. Sodium bicarbonate decreases plasma ionized calcium and increases PaCO2.
Technetium-99m Sulfur Colloid Imaging of Vascular Thrombosis in Pancreaticosplenic Transplant
Authors: CLEMENT J. GRASSI, ROBERT G.L. LEE, THOMAS C. HILL, MELVIN E. CLOUSE
Journal: Clinical Nuclear Medicine (1986)

A case of pancreaticosplenic transplant is presented, showing the utility of radionuclide angiography with Tc-99m sulfur colloid in the evaluation of vascular sufficiency.
Isolation of Lymphadenopathy-Associated Virus (LAV) and Detection of LAV Antibodies From US Patients With AIDS
Authors: Françoise Barré-Sinoussi
Journal: JAMA (1985)

A human retrovirus was isolated from the peripheral blood of three American patients newly diagnosed with the acquired immunodeficiency syndrome (AIDS). In each case the major core viral protein (p25) was shown to be antigenically identical to that of the prototype lymphadenopathyassociated virus (LAV). Two of the viral isolates were derived from intravenous narcotics abusers, the first demonstration of LAV isolation from this risk group. Antibody to LAV was detected by an IgG enzyme-linked immunosorbent assay in the serum samples of these and 14 additional American patients with AIDS and in none of 12 hospital worker controls. These findings provide support for the etiologic association of LAV and AIDS. (<i>JAMA</i>1985;253:1737-1739)
Viral Hepatitis: An Occupational Hazard to Surgeons
Authors: James L. Rosenberg
Journal: JAMA (1973)

An epidemic of serum hepatitis (hepatitis-associated antigen [HAA]-positive) among surgical house staff occurred at Albert Merritt Billings Hospital in the winter of 1971. Four surgeons, who had operated on a patient in whom HAA-positive serum hepatitis subsequently developed, were affected. Arthralgia or arthritis and rash were prominent clinical features of this outbreak. Reduced synovial fluid complement level and a synovial fluid that was HAA-positive were found in one of the surgeons. A detailed evaluation of the 75 medical and allied medical personnel who cared for this patient before, during, and after surgery uncovered no additional cases of hepatitis. We believe, therefore, that the serum hepatitis virus was transmitted to the surgeons while they were operating, most likely through tissue penetration by contaminated surgical instruments or materials.
Genetic evidence for a predominant role of PI3Kβ catalytic activity in ITAM- and integrin-mediated signaling in platelets
Authors: Ilaria Canobbio, Lucia Stefanini, Lina Cipolla, Elisa Ciraolo, Cristian Gruppi, Cesare Balduini, Emilio Hirsch, Mauro Torti
Journal: Blood (2009)
Should Survivors of Myocardial Infarction With Low Ejection Fraction Be Routinely Referred to Arrhythmia Specialists?
Authors: William G. Stevenson
Journal: JAMA (1996)

Because survivors of myocardial infarction are at risk for ventricular arrhythmias and sudden death, physicians must decide whether to refer these patients to specialists for arrhythmia assessment and therapy. However, this decision is complex as few randomized data are available concerning either diagnostic or therapeutic options. Therefore, we modeled the potential impact of current arrhythmia detection and management strategies on mortality in survivors of myocardial infarction with reduced left ventricular function who are managed in a contemporary manner. Based on recent data we estimated that the mortality for myocardial infarction survivors with left ventricular ejection fraction less than 0.40 is 20 percent over 3.5 years and that half of the deaths are sudden. The sensitivity and specificity of a Holter electrocardiogram (ECG), a signal-averaged ECG, and an invasive electrophysiology study for predicting sudden death were obtained from a literature review of trials published after 1990 that included more than 300 patients. A series of models were constructed to predict mortality achieved by different arrhythmia management strategies that reduced sudden death by 50 percent and 75 percent--reductions estimated to be within the range for amiodarone and implantable defibrillators. We found that, when routinely applied to all infarct survivors with depressed ventricular function, a therapy that reduces sudden death by 50 percent with 1 percent fatal adverse effects (potentially amiodarone) saves approximately 1 life for every 25 patients treated. Therapy that reduces sudden death by 75 percent with 2 percent fatal adverse effects (potentially implantable defibrillators) saves 1 life for every 14 patients treated. Using Holter ECG recordings, a signal-averaged ECG, or an invasive electrophysiology study to select higher-risk groups, 1 life can be saved for every 4 to 11 patients treated, and the negative impact of adverse effects can be reduced. However, to achieve this benefit, additional and potentially invasive arrhythmia testing must be applied to 28 to 47 patients for each life saved. Thus, with contemporary management of acute myocardial infarction, the risk of sudden death for survivors is sufficiently low that broad application of available antiarrhythmic therapies has limited potential for further improving survival, particularly if therapy also has significant adverse effects. Thus, routine referral to arrhythmia specialists is not warranted for the majority of infarct survivors and should be largely reserved for patients with serious, symptomatic arrhythmias.
A Neurological Tapestry
Authors: William C. Gibson
Journal: JAMA (1971)

Some time agoThe Journalpublished a description of a modern French tapestry, "Masters of Science," which hangs in the Woodward Biomedical Library of the University of British Columbia.<sup>1</sup>It was designed by Guillonet, and was worked by Roland of the Gobelins staff. Of prime interest to physicians, scientists such as Jenner, Claude Bernard, Pasteur, Roux, Richet, Descartes, and Lavoisier were depicted. Today's issue ofThe Journalfeatures on the cover another handsome product of French genius, by the same designer, "Masters of the Spirit." It was carried out, however, by a different craftsman who, for reasons which will be appreciated later, shall remain anonymous. The fact of the matter is that the man whose work we see today was aged 68 at the time of the creation of this colorful tapestry which measures 16 × 11 feet. It too was commissioned by the postwar patron of the new
Artefactual fetal heart trace in an undiagnosed dead fetus.
Authors: F N McLeod, D McCoy
Journal: BMJ (1984)

surgery and use of drugs that modify disease as both measures are objective and unlikely to be omitted from case notes and may be re- quired in severe chronic destructive disease.These measures were not associated with antinuclear antibody initially or subsequently, which is particularly notable as antinuclear antibody (and correlated rheumatoid factor) may be used as criteria for selection for surgery or second line drugs.The lack of correlation strongly suggests that the presence of antinuclear antibody initially is not an adverse prognostic indicator in rheumatoid arthritis; thus the test for antinuclear antibody is of little value in the routine assessment of straightforward rheumatoid arthritis.We thank Drs R D Sturrock and H A Capell for allowing us to study their patients, and Mrs V Eardley for typing the manuscript.
Fats and atheroma: an inquest.
Authors: K G Taylor, D J Betteridge
Journal: BMJ (1979)

prostacyclin production if the non-precursor fats are peroxidised.4Certainly, to choose a margarine with a high content of C18:2co6 in the cis form needs more information than is provided on the label, and none exists with a high content of eicosapentaenoic acid, which may be preferable.From the point of view of a healthy cardio- vascular system, it could be that we should be debating a fat intake based on fish rather than meat, instead of butter versus margarine.
Myelomatous Plasma Cells Display An Intermediate Gene Expression Pattern Between a Normal Plasma Cell and a Memory B Cell
Authors: Alicia Baez, Jose Ignacio Piruat, Teresa Caballero-Velazquez, María Victoria Barbado, Isabel Alvarez-Laderas, Africa Millan-Ucles, Mayte Medrano, Estefania Garcia-Guerrero, Luis Ignacio Sanchez-Abarca, Ildefonso Espigado, Jose Antonio Perez-Simón
Journal: Blood (2013)