tbuckley/cabot-search huggingface dataset:
Abstract 3865: The rGel/BLyS fusion toxin enhances the therapeutic effects of bortezomib in i<i>n vitro</i> and i<i>n vivo</i> models of mantle cell lymphoma.
Authors: Mi-Ae Lyu, Lan V. Pham, Bokyung Sung, Archito T. Tamayo, Kwang Seok Ahn, Lawrence H. Cheung, John W. Marks, Richard J. Ford, Bharat B. Aggarwal, Michael G. Rosenblum
Journal: Cancer Research (2012)

Abstract Mantle cell lymphoma (MCL) is an incurable, aggressive histo-type of B-cell non-Hodgkin lymphoma associated with both high relapse rates and relatively short survival. MCL is a therapeutic challenge and presents an opportunity for the application of novel, targeted agents. Because MCL over-expresses receptors for B lymphocyte stimulator (BLyS) and displays constitutively active NF-κB, agents targeting these pathways may be of therapeutic relevance in this disease. To explore the potential clinical use of the rGel/BLyS fusion toxin in combination with bortezomib in MCL, we evaluated this fusion toxin for its ability to inhibit MCL growth in a severe combined immunodeficiency (SCID) xenograft model. Compared with PBS-treated mice, mice treated with rGel/BLyS showed both prolonged median (84 d vs. 125 d) and overall survival (40%) (p=0.0027). Compared with bortezomib alone-treated mice, mice treated with rGel/BLyS plus bortezomib showed significant median (91d vs. 158d) and overall survival (20%) (p=0.0127). Histopathologic analysis of peritoneal intestinal mesentery from MCL-SCID mice showed no demonstrable microscopic lymphomatous involvement at 225 days after treatment with rGel/BLyS. Followup in vitro mechanistic studies demonstrated that the rGel/BLyS plus bortezomib combination resulted in an additive or a synergistic growth inhibition, reduction of NF-κB DNA-binding activity, inhibition of cyclin D1, Bcl-xL, p-Akt, and Akt and up-regulation of Bax. We additionally found that combination treatment caused induction of apoptosis associated with caspase-9, caspase-3 activation and PARP cleavage. rGel/BLyS is an effective therapeutic agent for both primary and savage treatment of aggressive MCL and may be an excellent candidate for clinical development. This research was conducted, in part, by the Clayton Foundation for Research and by a Translational Research Award (LLS 6234-07) from the Leukemia and Lymphoma Society. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3865. doi:1538-7445.AM2012-3865
CONVULSIVE STATES WITH EVIDENCE OF BRAIN HEMIATROPHY
Authors: LOUIS CASAMAJOR, ROBERT W. LAIDLAW
Journal: American Journal of Psychiatry (1939)

1. Attention is called to a roentgenographic syndrome of hemilateral cerebral hypoplasia and atrophy with concomitant increase of thickness of the skull and enlargement of the head sinuses which occurs in certain convulsive states. 2. Nine cases are described which presented this syndrome. The etiological factors were traumatic, inflammatory or vascular. 3. The nature of the pathological process is discussed from the point of view of brain growth.
Potential Impact of<i>DSM-5</i>Criteria on Autism Spectrum Disorder Prevalence Estimates
Authors: Matthew J. Maenner, Catherine E. Rice, Carrie L. Arneson, Christopher Cunniff, Laura A. Schieve, Laura A. Carpenter, Kim Van Naarden Braun, Russell S. Kirby, Amanda V. Bakian, Maureen S. Durkin
Journal: JAMA Psychiatry (2014)

The DSM-5 contains revised diagnostic criteria for autism spectrum disorder (ASD) from the DSM-IV-TR. Potential impacts of the new criteria on ASD prevalence are unclear.To assess potential effects of the DSM-5 ASD criteria on ASD prevalence estimation by retrospectively applying the new criteria to population-based surveillance data collected for previous ASD prevalence estimation.Cross-sectional, population-based ASD surveillance based on clinician review of coded behaviors documented in children's medical and educational evaluations from 14 geographically defined areas in the United States participating in the Autism and Developmental Disabilities Monitoring (ADDM) Network in 2006 and 2008. This study included 8-year-old children living in ADDM Network study areas in 2006 or 2008, including 644 883 children under surveillance, of whom 6577 met surveillance ASD case status based on the DSM-IV-TR.Proportion of children meeting ADDM Network ASD criteria based on the DSM-IV-TR who also met DSM-5 criteria; overall prevalence of ASD using DSM-5 criteria.Among the 6577 children classified by the ADDM Network as having ASD based on the DSM-IV-TR, 5339 (81.2%) met DSM-5 ASD criteria. This percentage was similar for boys and girls but higher for those with than without intellectual disability (86.6% and 72.5%, respectively; P < .001). A total of 304 children met DSM-5 ASD criteria but not current ADDM Network ASD case status. Based on these findings, ASD prevalence per 1000 for 2008 would have been 10.0 (95% CI, 9.6-10.3) using DSM-5 criteria compared with the reported prevalence based on DSM-IV-TR criteria of 11.3 (95% CI, 11.0-11.7).Autism spectrum disorder prevalence estimates will likely be lower under DSM-5 than under DSM-IV-TR diagnostic criteria, although this effect could be tempered by future adaptation of diagnostic practices and documentation of behaviors to fit the new criteria.
Interferon Alfa-2b Three Times Daily and Thalidomide in the Treatment of Metastatic Renal Cell Carcinoma
Authors: Micaela Hernberg, Pekka Virkkunen, Petri Bono, Henna Ahtinen, Hanna Mäenpää, Heikki Joensuu
Journal: Journal of Clinical Oncology (2003)

The antiangiogenic effect of interferon (IFN) may improve with frequent dosing and by combination with other agents with antiangiogenic activity. To evaluate this potential, we treated patients with metastatic renal cell carcinoma (RCC) with frequently dosed IFN and thalidomide.Thirty patients were given IFN-alpha-2b 0.9 MU subcutaneously three times daily for 1 month and subsequently 1.2 MU tid unless serious toxicity was encountered. Thalidomide was first given 100 mg/d for 1 week and 300 mg/d thereafter. Sera were collected before and during treatment for serum vascular endothelial growth factor (S-VEGF) analyses performed using enzyme-linked immunosorbent assay.The intention-to-treat response rate was 20% (95% CI, 6% to 34%) and response rate for assessable patients (n = 27) was 22% (95% CI, 6% to 38%). All responses were partial. In addition, 17 patients (63%; 95% CI, 45% to 81%) had stable disease for 3 months or longer. The median time to treatment failure was 7.7 months, and median survival time was 14.9 months. The most common cause of thalidomide discontinuation was neuropathy. S-VEGF levels decreased more in patients who responded to therapy compared with those in patients whose condition had stabilized or who had progressive disease (P =.036).The combination of frequently dosed IFN-alpha-2b and low-dose thalidomide is feasible and active in advanced RCC, but the clinical benefit may remain small compared with that of IFN alone. Results from an ongoing phase III trial comparing IFN-alpha with or without thalidomide need to be analyzed before this combination can be recommended for use outside clinical studies.
Midwife managed delivery unit: a randomised controlled comparison with consultant led care
Authors: V A Hundley, F M Cruickshank, G D Lang, C M A Glazener, J M Milne, M Turner, D Blyth, J Mollison, C Donaldson
Journal: BMJ (1994)

To examine whether intrapartum care and delivery of low risk women in a midwife managed delivery unit differs from that in a consultant led labour ward.Pragmatic randomised controlled trial. Subjects were randomised in a 2:1 ratio between the midwives unit and the labour ward.Aberdeen Maternity Hospital, Grampian.2844 low risk women, as defined by existing booking criteria for general practitioner units in Grampian. 1900 women were randomised to the midwives unit and 944 to the labour ward.Maternal and perinatal morbidity.Of the women randomised to the midwives unit, 647 (34%) were transferred to the labour ward antepartum, 303 (16%) were transferred intrapartum, and 80 (4%) were lost to follow up. 870 women (46%) were delivered in the midwives unit. Primigravid women (255/596, 43%) were significantly more likely to be transferred intrapartum than multi-gravid women (48/577, 8%). Significant differences between the midwives unit and labour ward were found in monitoring, fetal distress, analgesia, mobility, and use of episiotomy. There were no significant differences in mode of delivery or fetal outcome.Midwife managed intrapartum care for low risk women results in more mobility and less intervention with no increase in neonatal morbidity. However, the high rate of transfer shows that antenatal criteria are unable to determine who will remain at low risk throughout pregnancy and labour.
Diet and colorectal cancer: fibre back on the menu?
Authors: R P Arasaradnam
Journal: Gut (2003)

Cyclooxygenase 2 selective inhibitor induced bowel stricture: a case report Several reports have mentioned the role of non-steroidal anti-inflammatory drugs (NSAID) in inducing diaphragm disease and strictures in the small and large bowel. [1]2][3] To our knowledge, there is no such report in patients treated with cyclooxygenase 2 (COX-2) selective inhibitors.We report the case of a 55 year old man with a past history of axial spondylarthropathy, successfully treated with NSAID from 1975 to 2001; from February 2001, he was treated with celecoxib 400 mg per day for three weeks and then 200 mg/day for two years.He had previous abdominal surgery (appendicectomy) in 1965.He presented with a 24 hour history of central abdominal pain with persistent vomiting.Clinical and radiological examination confirmed small bowel obstruction.At laparoscopy, a distal ileal obstruction was identified.Coelioscopic laparotomy was then performed, showing evidence of bowel wall stricture; 10 cm of the distal ileum was spared.Macroscopic and microscopic examination of the resected specimen was consistent with a diagnosis of stricture on submucosal ulceration of the small bowel.This condition is known to be associated with long term use of NSAID.The COX-2 specific inhibitors have been developed in order to improve the gastrointestinal safety of therapy with NSAID.In various clinical trials, COX-2 selective inhibitors have been shown to have similar efficacy to NSAID, with a concomitant association with fewer endoscopic ulcers and serious lower gastrointestinal events. 3 This case suggests that COX-2 selective inhibitors can induce bowel wall ulcerations, followed by submucosa fibrosis, which may cause strictures or diaphragm-like disease.
Adverse Effects of Contact Lens Wear During Decompression
Authors: David R. Simon
Journal: JAMA (1980)

The effects of corneal contact lens wear during and after exposures for 30 minutes to a depth of 45.5 m (150 ft of sea water) or an altitude of 11,277 m (37,000 ft) were studied. Subjects wore either membrane (soft) lenses or one of two types of polymethylmethacrylate (hard) lenses: fenestrated (0.4-mm hole in the center) or nonfenestrated. During and after decompression from the dive, subjects wearing nonfenestrated polymethylmethacrylate lenses experienced ocular symptoms, the result of corneal epithelial edema caused by formation and trapping of nitrogen bubbles in the precorneal tear film. No bubbles, or only a few miniscule ones, and no symptoms were present when lenses were not worn during the dive or at a high altitude. The reasons why gas trapping and corneal edema do or do not occur are discussed and recommendations for contact lens wear are proposed.
Criteria for the Diagnosis of Malnutrition
Authors: Robert M. Craig
Journal: JAMA (1986)

<h3>To the Editor.—</h3> The assessment of a patient's nutritional status is complex, and simplistic laboratory tests are generally inadequate in this analysis. For example,The Journalrecently published a study in which serum albumin levels were used as the major criterion for malnutrition.<sup>1</sup>In this study, serum cholesterol levels were adjusted for nutritional influences by using the serum albumin level as a nutritional marker. The problem with using serum albumin or any other serum protein marker as an index of adequate nutrition is the influence of other nonnutritional factors on their levels. A decreased serum protein value could only be considered "nutritional" if it is due to a diminished supply of a nutrient or nutrients and not due to the underlying host disease processes. Two clinical examples highlight these issues. The first is a fasted patient who is otherwise healthy and whose serum albumin and other serum protein levels
Treatment of Hyperthyroidism
Authors: Joel I. Hamburger
Journal: JAMA (1984)

<h3>To the Editor.—</h3> Perhaps nostalgia for the seminal 1940s studies of Astwood led Landau<sup>1</sup>to resurrect the archaic calumny that radioactive iodine therapy for hyperthyroidism may cause thryoid cancer and is "usually reserved for patients older than 30 or 40 years of age." Do knowledgeable physicians really still harbor this or other theoretical fears of past generations despite a vast body of scientific data showing the safety of iodine 131? Conversations with Drs George Crile, Jr, and Earl Chapman have convinced me that the detection of fewer thyroid cancers after<sup>131</sup>I than would be expected in a similar portion of the population at large means that<sup>131</sup>I prevents cancer, for the same reason that so many patients require thyroxine afterward. Potential hypothyroidism (if patients are derelict in taking thyroxine) is the only established complication of<sup>131</sup>I. Although physicians must decide for themselves if the benefits of<sup>131</sup>
Review: Several brief screening tests detect dementia in older adults; no trials assess effects on patient outcomes
Authors: David Burke
Journal: Annals of Internal Medicine (2014)

Source Citation Lin JS, O’Connor E, Rossom RC, Perdue LA, Eckstrom E. Screening for cognitive impairment in older adults: a systematic review for the US Preventive Services Task Force. Ann Intern Med. 2013;159:601-12. 24145578
Sodium Excretion and Risk of Developing Coronary Heart Disease
Authors: Michel M. Joosten, Ron T. Gansevoort, Kenneth J. Mukamal, Hiddo J. Lambers Heerspink, Johanna M. Geleijnse, Edith J.M. Feskens, Gerjan Navis, Stephan J.L. Bakker
Journal: Circulation (2014)

Background— Despite compelling evidence for sodium’s adverse effects on blood pressure, it remains uncertain whether excess sodium intake is a risk factor for coronary heart disease (CHD) in the overall population and in potentially more susceptible subgroups. Methods and Results— We prospectively followed 7543 adults aged 28 to 75 years and free of cardiovascular and kidney disease in 1997/1998 of the Prevention of Renal and Vascular End-stage Disease (PREVEND) study. Sodium excretion was measured in two 24-hour urine collections at baseline. Potential susceptibility factors were blood pressure and plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP). Median 24-hour sodium excretion was 137 mmol (Q1–Q3, 106–171 mmol). During a median follow-up of 10.5 (Q1–Q3: 9.9–10.8) years, 452 CHD events occurred. In the entire cohort, there was no association between each 1-g/d (43 mmol/24 h) increment in sodium excretion and CHD risk (adjusted hazard ratio, 1.07; 95% confidence interval, 0.98–1.18; P =0.15). However, the association of sodium excretion with CHD risk tended to be modified by mean arterial pressure ( P interaction =0.08) and was modified by NT-proBNP ( P interaction =0.002). When stratified, each 1-g/d increment in sodium excretion was associated with an increased risk for CHD in subjects with hypertension (adjusted hazard ratio, 1.14; 95% confidence interval, 1.01–1.28; n=2363) and in subjects with NT-proBNP concentrations above the sex-specific median (adjusted hazard ratio, 1.16; 95% confidence interval, 1.03–1.30; n=3771). Conclusions— Overall, there was no association between sodium excretion and risk of CHD. The association between sodium excretion and CHD risk was modified by NT-proBNP. Higher sodium excretion was associated with an increased CHD risk among subjects with increased NT-proBNP concentrations or with hypertension.
People v Henderson: The Prosecution Responds-Reply
Authors: Steven B. Karch
Journal: JAMA (1996)

<h3>In Reply.</h3> —We appreciate the letter from the prosecuting attorney. It illustrates eloquently the difficulties we had with this case. If there were a law that states a mother is totally responsible for any adverse event in her child's life, then Ms Henderson would be guilty. But is not that the same type of reasoning that put many parents of infants who died of sudden infant death syndrome (SIDS) in jail? Our point was and still is that it is improper to pretend to use science to adjudicate a predetermined end. Regarding the reimbursement received for testifying, we received a total of $11135. As itemized in the Editor's note, this sum barely covered out-of-pocket expenses and does not reflect the time and professional work we devoted to this case. Ms Green assumes that the methamphetamine came from breast milk, although the mother had not used the drug for 2 or
Preparing for Surgery: Evaluation of Lung Function
Authors: Janet M. Torpy, Cassio Lynm, Richard M. Glass
Journal: JAMA (2007)

Preparing for Surgery: Evaluation of Lung Function Lung diseases, such as chronic obstructive pulmonary disease (COPD), also called emphysema, affect an individual' s ability to tolerate surgical procedures.Lung function, the ability of the lungs to provide oxygen to the body and remove carbon dioxide, is a critical factor in an individual' s perioperative (the time period surrounding an operation) well-being.To reduce risk of pulmonary problems during and after an operation, your doctors may order tests and medications.Doctors involved in preparing you for a procedure may include your primary care physician, your surgeon, your anesthesiologist, and other specialists including pulmonologists (doctors with specialized education in treating lung diseases).The type of anesthesia you receive may depend on your lung function.Sometimes persons with severe lung disease need to remain on a ventilator (breathing machine) after surgery; others may require oxygen and respiratory treatments afterward.COPD also increases the risk of pneumonia after surgery.The May 16, 2007, issue of JAMA includes an article about evaluating COPD and other lung diseases in preparation for surgical procedures.
Standardized MRD flow and ASO IGH RQ-PCR for MRD quantification in CLL patients after rituximab-containing immunochemotherapy: a comparative analysis
Authors: S Böttcher, S Stilgenbauer, R Busch, M Brüggemann, T Raff, C Pott, K Fischer, G Fingerle-Rowson, H Döhner, M Hallek, M Kneba, M Ritgen
Journal: Leukemia (2009)
(2) A double-blind placebo-controlled trial of topical hexyl nicotinate lotion in primary Raynaud's phenomenon
Authors: C.B. Bunker, F. Cooper, Pauline M. Dowd
Journal: British Journal of Dermatology (1989)

Journal Article (2) A double‐blind placebo‐controlled trial of topical hexyl nicotinate lotion in primary Raynaud's phenomenon Get access C.B. Bunker, C.B. Bunker Department of Dermatology, University College and Middlesex School of Medicine, London Search for other works by this author on: Oxford Academic Google Scholar F. Cooper, F. Cooper Department of Dermatology, University College and Middlesex School of Medicine, London Search for other works by this author on: Oxford Academic Google Scholar Pauline M. Dowd Pauline M. Dowd Department of Dermatology, University College and Middlesex School of Medicine, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 121, Issue s34, 1 July 1989, Pages 51–52, https://doi.org/10.1111/j.1365-2133.1989.tb05953.x Published: 01 July 1989
Endotoxin stimulates hydrogen peroxide detoxifying activity in rat hepatic endothelial cells
Authors: Z Spolarics, D S Stein, Z C Garcia
Journal: Hepatology (1996)

The study aimed to assess the effect of lipopolysaccharide (LPS) in vivo (from Escherichia coli , 2 mg/kg body weight intraperitoneally) on the production and elimination of hydrogen peroxide (H2O2) in rat hepatic endothelial and Kupffer cells. Twenty–two hours after the injection of LPS, hepatic cells were isolated by collagenase and pronase digestion followed by centrifugal elutriation, and cell– associated H2O2 was determined by flow cytometry analysis using 2′,7′– dichloroflorescin diacetate (DCF–diacetate). LPS treatment did not alter the basal or phorbol myristate acetate–stimulated levels of H2O2– related fluorescence in endothelial cells; however, it doubled phorbol myristate acetate–stimulated fluorescence in Kupffer cells. Administration of varying concentrations of H202 (range, 10-7 – 10-4 mol/L) in vitro caused a significantly delayed increase in fluorescence in endothelial cells from endotoxemic rats as compared with cells from saline–injected animals. The 50% effective concentration of H2O2 was found at 1.1 × 10-6 and 8.1 × 10-6 mol/L on endothelial cells after saline and LPS treatment, respectively. No differences were detected in H2O2–stimulated fluorescence between resting and LPS–stimulated Kupffer cells. Administration of varying glucose concentrations in vitro significantly decreased the H2O2– stimulated fluorescence in endothelial and Kupffer cells from LPS– injected animals. Inhibition of nitric oxide synthase by in vitro administration of NG–monomethyl–L–arginine (L–NNMMA) did not alter the H2O2– or phorbol myristate acetate–stimulated responses in endothelial and Kupffer cells. As shown earlier, LPS stimulates the gene expression of GLUT1 glucose transporter, glucose–6–phosphate dehydrogenase (G6PD), superoxide dismutases, and glutathione peroxidase in hepatic endothelial cells. The present data indicate that the LPS–induced metabolic alterations are accompanied by an increased H2O2–detoxifying capacity in hepatic endothelial cells. This may represent a protective mechanism against exogenous oxidative stress caused by activated hepatic phagocytes during inflammation. Our observations are consistent with primed production of reactive oxygen species (ROS) in LPS–activated Kupffer cells.
Depression: Comparative Studies of Normal, Neurotic, and Psychotic Conditions
Authors: Alfred Flarsheim
Journal: JAMA (1972)

The title of this work might lead us to expect a comprehensive text on depressive illness, but this is not the author's intent. Edith Jacobson is an outstanding psychoanalytic clinician and theoretician. This book is a collection of her papers on the psychoanalytic conceptualization and treatment of depression, as it appears in normal mood swings and in neurotic and psychotic personalities.  Furthermore, the book is not designed to be a comprehensive study of all psychoanalytic views of depression. Rather, it records the struggles of one particularly gifted person to understand depression within the framework of classical Freudian psychoanalytic theory and the ego-psychological studies of Heinz Hartmann. In all of the papers Dr. Jacobson presupposes familiarity with classical psychoanalytic concepts and with the influential work of Hartmann.  The book starts with a 40-page paper on the psychoanalytic theory of affects. Some readers may have difficulty following Jacobson's theoretical exposition. For them
255 MIR-22 PROMOTES HEPATOCELLULAR CARCINOMA DEVELOPMENT IN MALES BY SUPPRESSING ESTROGEN SIGNALING AND UPREGULATING INTERLEUKIN-1 ALPHA EXPRESSION
Authors: R. Jiang, L. Deng, L. Zhao, X. Li, F. Zhang, Y. Gao, Y. Xia, X. Wang, B. Sun
Journal: Journal of Hepatology (2011)