tbuckley/cabot-search huggingface dataset:
Automated, Multiplex Assay for High-Frequency Microsatellite Instability in Colorectal Cancer
Authors: G.M. Nash, M. Gimbel, J. Shia, A.T. Culliford, D.R. Nathanson, M. Ndubuisi, Y. Yamaguchi, Z.S. Zeng, F. Barany, P.B. Paty
Journal: Journal of Clinical Oncology (2003)

In a series of hereditary nonpolyposis colorectal cancer (HNPCC) patients, we evaluated the sensitivities of the individual microsatellites recommended by the National Cancer Institute (NCI) consensus workshop for detection of high-frequency microsatellite instability (MSI-H). On the basis of this evaluation, we developed a three-marker assay that assigns microsatellite instability (MSI) in a multiplex polymerase chain reaction.Individual marker sensitivity was assessed in 18 HNPCC tumors. Multiplex and NCI assays were then assessed in a series of 120 patients with early-onset colon cancer.The sensitivity of microsatellite markers BAT25, BAT26, D2S123, D5S346, and D17S250 for ASI in HNPCC cancers was 100%, 94%, 72%, 50%, and 50%, respectively. The three most accurate markers were combined and optimized in a multiplex assay that assigned MSI-H whenever at least two of three markers revealed ASI. In early-onset colon cancers, the prevalence of MSI-H determined by the multiplex assay and by the NCI assay was 16% and 23%, respectively. The additional MSI-H tumors and patients with MSI-H identified by the NCI assay lacked the traits characteristic of MSI-H seen in tumors and patients identified by the multiplex assay: retention of heterozygosity (NCI additional 22% v multiplex 84%; P =.003), characteristic tumor morphology (0% v 64%; P =.006), and 5-year cancer survival rate (44% v 100%; P =.0003).The multiplex assay identifies colon cancers with MSI-H by assessing three highly accurate microsatellite markers. This assay identifies a smaller MSI-H cohort with more homogeneous clinical features and is superior as a marker of favorable prognosis. It merits prospective evaluation as a marker of prognosis and as a screening test for HNPCC.
TRENDS AND PREDICTORS OF LENGTH OF STAY AFTER PRIMARY PERCUTANEOUS CORONARY INTERVENTION: A REPORT FROM THE NATIONAL CARDIOVASCULAR DATA REGISTRY
Authors: Chee Tang Chin, Tracy Y. Wang, David Dai, Matthew T. Roe, Rajendra H. Mehta, John S. Rumsfeld, H. Vernon Anderson, William S. Weintraub, John C. Messenger, Michael A. Kutcher, Ralph G. Brindis, Eric D. Peterson, Robert A. Harrington, Sunil V. Rao
Journal: Journal of the American College of Cardiology (2010)
Nasal Smear as a Screening Test for Immediate‐Type Nasal Allergy
Authors: H. Malmberg, E. Holopainen
Journal: Allergy (1979)

From a previous sample of 634 students and school children, 115 subjects were selected for a thorough rhinological examination and allergy work‐up in order to assess the value of nasal secretion eosinophilia in screening for immediate‐type nasal allergy. Part of the subjects had, in the previous study, been found to have secretion eosinophilia and a history of chronic/allergic rhinitis, part of the subjects had either a secretion eosinophilia or a rhinitis history, and part of them had neither a secretion eosinophilia nor a rhinitis history. A significant correlation was obtained between secretion eosinophilia and allergy. Nasal provocation tests correlated with skin tests in 87%, whereas the correlation between nasal provocation tests and IgE determinations in the serum was poorer. Thickening of the maxillary sinus was, when present, usually attributable to infection and not to allergy. Reasons for “false positive or false negative” smears for eosinophils are discussed.
Cranial Bruits in Purulent Meningitis in Childhood
Authors: John W. Mace, Earl R. Peters, Allen W. Mathies
Journal: New England Journal of Medicine (1968)

The frequency of cranial bruits in 55 patients with purulent meningitis as compared to that of 653 afebrile and 155 febrile patients without meningitis showed that 82 per cent of the patients with purulent meningitis between the ages of three months and five years had cranial bruits whereas bruits were heard in 22 per cent in the febrile control group and 16 per cent in the afebrile control group. The bruits associated with purulent meningitis are usually transitory, lasting one to four days after initiation of therapy. In three of the patients with purulent meningitis cranial bruits recurred in association with the development of subdural effusions. These bruits disappeared as the subdural effusions cleared. Cranial bruits may be another diagnostic point in the recognition of purulent meningitis, subdural effusions and other conditions associated with increased intracranial pressure.
Dialysis Fistula and Heart Failure
Authors: BARUCH J. HURWICH
Journal: Annals of Internal Medicine (1974)

Comments1 April 1974Dialysis Fistula and Heart FailureBARUCH J. HURWICH, M.D.BARUCH J. HURWICH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-4-561 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I wish to question the validity of Dr. Ronald A. Draur's conclusion that three dialysis patients' arteriovenous fistulas caused heart failure (Ann Intern Med 79:765, 1973). His table suggests that closure of the fistulas resulted in a decrease of blood flow of 11000, 1100, and 1960 ml/min through the affected limb, as the differences in cardiac output imply indirect measurements of flow through the fistula.Since several studies corroborated my findings (1), by plethysmographic methods, that mean flow through a radial arteriovenous fistula is about 220 ml/min, Dr. Draur's results, especially the first figure, seem excessive. In...References1. HURWICH B: Plethysmographic forearm blood flow studies in maintenance hemodialysis patients with radial arteriovenous fistulae. Nephron 6:673-678, 1969 CrossrefMedlineGoogle Scholar2. PATESHERMANJACKSON JRT: Cardiac failure following traumatic arteriovenous fistula: a report of fourteen cases. J Trauma 5:398-403, 1965 CrossrefMedlineGoogle Scholar3. FRIEDBERG C: Diseases of the Heart, 5th ed. Philadelphia, W. B. Saunders Co., 1966, p. 1122 Google Scholar1. HOLMAN E: Abnormal A-V communications. Circulation 32: 1001-1009, 1965 CrossrefMedlineGoogle Scholar2. AHEARNMAHER DJ: Heart failure as a complication of hemodialysis arteriovenous fistula. Ann Intern Med 77:201-204, 1972 LinkGoogle Scholar3. GRAETTINGERPARSONSCAMPBELL JRJ: A correlation of clinical and hemodynamic studies in patients with mild and severe anemia with and without congestive failure. Ann Intern Med 58:617-626, 1963 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAccess Ligation in Transplant Patients 1 April 1974Volume 80, Issue 4Page: 561-562KeywordsBlood flowCardiac outputFistulasHeart failureMedical dialysis Issue Published: 1 April 1974 PDF DownloadLoading ...
Diagnostic Performance of Computed Tomography Angiography in Peripheral Arterial Disease
Authors: Rosemarie Met, Shandra Bipat, Dink A. Legemate, Jim A. Reekers, Mark J. W. Koelemay
Journal: JAMA (2009)

<h3>Context</h3>Computed tomography angiography (CTA) is an increasingly attractive imaging modality for assessing lower extremity peripheral arterial disease (PAD).<h3>Objective</h3>To determine the accuracy of CTA compared with intra-arterial digital subtraction angiography (DSA) in differentiating extent of disease in patients with PAD.<h3>Data Sources and Study Selection</h3>Search of MEDLINE (January 1966-August 2008), EMBASE (January 1980-August 2008), and the Database of Abstracts of Reviews of Effectiveness for studies comparing CTA with intra-arterial DSA for PAD. Eligible studies compared multidetector CTA with intra-arterial DSA, included at least 10 patients with intermittent claudication or critical limb ischemia, aimed to detect more than 50% stenosis or arterial occlusion, and presented either 2 × 2 or 3 × 3 contingency tables (≤50% stenosis vs &gt;50% stenosis or occlusion), or provided data allowing their construction.<h3>Data Extraction</h3>Two reviewers screened potential studies for inclusion and independently extracted study data. Methodological quality was assessed by using the QUADAS instrument.<h3>Data Synthesis</h3>Of 909 studies identified, 20 (2.2%) met the inclusion criteria. These 20 studies had a median sample size of 33 (range, 16-279) and included 957 patients, predominantly with intermittent claudication (68%). Methodological quality was moderate. Overall, the sensitivity of CTA for detecting more than 50% stenosis or occlusion was 95% (95% confidence interval [CI], 92%-97%) and specificity was 96% (95% CI, 93%-97%). Computed tomography angiography correctly identified occlusions in 94% of segments, the presence of more than 50% stenosis in 87% of segments, and absence of significant stenosis in 96% of segments. Overstaging occurred in 8% of segments and understaging in 15%.<h3>Conclusion</h3>Computed tomography angiography is an accurate modality to assess presence and extent of PAD in patients with intermittent claudication; however, methodological weaknesses of examined studies prevent definitive conclusions from these data.
BLOOD LOSS DURING OPERATIONS
Authors: Harry C. Saltzstein
Journal: JAMA (1952)

There have been enough significant studies reported to show that measuring blood loss during an operation is a practical and worth-while procedure. Although it has become a standard method in some clinics, it is not a generally accepted and routine practice. Gatch and Little,<sup>1</sup>in 1924, were the first to measure blood loss. Blain,<sup>2</sup>in 1929, commenting on his experience with 3,000 transfusions, noted that "the amount of blood lost during operations is often several times greater than that estimated by the surgeon." Within the past few years articles by Coller and his associates and by Stewart,<sup>3</sup>studies from Wangensteen's clinic, and reports by several others have resulted in the following conclusions: The blood loss is always greater than the surgeon may estimate or anticipate. There is no correlation between the amount of blood lost and the changes in the hematocrit, hemoglobin, red blood cell
Cost-Effectiveness Analyses
Authors: Charles M. Clark
Journal: Annals of Internal Medicine (2001)

Letters4 September 2001Cost-Effectiveness AnalysesCharles M. Clark Jr, MDCharles M. Clark Jr, MDIndiana University School of Medicine; Regenstrief Institute; Indianapolis, IN 46202 (Clark)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-5-200109040-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Cost-effectiveness analyses, such as those published in the 16 May 2000 issue (1, 2), perform an important clinical and policy function. I am, however, puzzled by the lack of distinction in such analyses between the cost-effectiveness of the decision to initiate therapy and the cost-effectiveness of setting goals after therapy is initiated. Modern pharmacologic treatments for the major risk factors for cardiovascular disease (hypertension, hyperlipidemia, and diabetes), while expensive, are effective and safe and have little negative effect on quality of life. Currently, cost-effectiveness analyses focus on the cost of these drugs and try to define where ...References1. Prosser LA, Stinnett AA, Goldman PA, Williams LW, Hunink MG, Goldman L, et al . Cost-effectiveness of cholesterol-lowering therapies according to selected patient characteristics. Ann Intern Med. 2000;132:769-79. [PMID: 10819699] LinkGoogle Scholar2. Ganz DA, Kuntz KM, Jacobson GA, Avorn J. Cost-effectiveness of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor therapy in older patients with myocardial infarction. Ann Intern Med. 2000;132:780-7. [PMID: 10819700] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Charles M. ClarkJr, MDAffiliations: Indiana University School of Medicine; Regenstrief Institute; Indianapolis, IN 46202 (Clark) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCost-Effectiveness of Cholesterol-Lowering Therapies according to Selected Patient Characteristics Lisa A. Prosser , Aaron A. Stinnett , Paula A. Goldman , Lawrence W. Williams , Maria G.M. Hunink , Lee Goldman , and Milton C. Weinstein Cost-Effectiveness of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor Therapy in Older Patients with Myocardial Infarction David A. Ganz , Karen M. Kuntz , Gretchen A. Jacobson , and Jerry Avorn Cost-Effectiveness Analyses Lisa A. Prosser , Aaron A. Stinnett , Lee Goldman , and Milton C. Weinstein Metrics 4 September 2001Volume 135, Issue 5 Page: 382 Keywords Drugs Hemoglobin High density lipoprotein cholesterol Hyperlipidemia Hypertension Hypoglycemia Medical risk factors Quality adjusted life years Quality of life Statins ePublished: 4 September 2001 Issue Published: 4 September 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Plasma Renin Activity in Primary Aldosteronism-Reply
Authors: J. W. Conn
Journal: JAMA (1965)

<h3>To the Editor:—</h3> We are pleased with the opportunity to respond to the letter submitted by Drs. Brown, Davies, Lever, and Robertson, conconcerning two papers from my laboratory which appeared in the Oct 19, 1964, issue ofThe Journal. The first paper, by me and two of my colleagues, presents carefully collected data, together with our interpretation of them. Dr. Brown and his colleagues raise no serious objection to the major points of this paper or to the conclusions that we have drawn from our data. In fact, they suggest that they had come to the same conclusions before we had. While this is not correct, we are not concerned with the question of priority and are pleased that the two groups agree that a hypertensive hypokalemic patient, exhibiting both overproduction of aldosterone and a suppressed capacity to release renin into the blood, has primary aldosteronism. <b>The second paper</b>(which
Youth Suicide and Access to Guns
Authors: Frederick P. Rivara
Journal: JAMA Pediatrics (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Successful allogeneic bone marrow transplantation after reversion to chronic phase of blast crisis in chronic myeloid leukemia
Authors: J. P. Vernant, M. Rodet, H. Rochant, F. Feuilhade, A. Thuran, P. Bierling, M. C. Lesc, P. Mannoni, B. Dreyfus
Journal: American Journal of Hematology (1981)

Abstract A female with chronic myeloid leukemia (XX Ph 1 +) in blast crisis (localized to pleura and lymph nodes) was treated by polychemotherapy. After reversion to the chronic phase, an allogeneic bone marrow transplantation (BMT) was performed. Sixteen months after BMT, no sign of the disease was present (XY Ph 1 ‐).
Refusal of Care by Patients
Authors: Susannah M. Bernheim, Joseph S. Ross, Elizabeth H. Bradley
Journal: JAMA (2006)

To the Editor: In the Grand Rounds discussion of a patient’s refusal of care, Dr Carrese describes a familiar and difficult case in which respect for patient autonomy conflicts with the principle of beneficence: an older bedbound woman, judged competent to make medical decisions, refuses nursing home care after a hospitalization, yet the medical team is concerned that she cannot receive sufficient care at home to prevent further deterioration. Carrese presents an ethical framework within which to view this case, but we believe an important perspective is sidelined in his discussion. Optimal care for this patient, allowing her to return home with sufficient nursing care, is prohibited by her financial circumstances. The physicians’ responsibilities to promote beneficence and patient autonomy are in conflict only because of the patient’s socioeconomic status. Physicians who care for patients with low socioeconomic status may be faced with reconciling the promotion of high-quality care for all patients with the need to adapt care to individuals’ socioeconomic circumstances. Financial stresses and lack of social support, as faced by the woman discussed by Carrese, can force physicians to choose treatment options that are not optimal. The number of patients who are unable to afford appropriate care is increasing, even among the insured, and it is likely that physicians face the dilemma of such compromises with increasing frequency. These situations have important implications for the definition of quality of care. Incorporating a patient’s social context into decision making is an aspect of patient-centered care, albeit one that can lead to difficult choices. Willingness to discuss these clinical dilemmas may help to define and promote high-quality care for all patients.
EXPERIMENTAL ARTHRITIS IN THE RABBIT. A CONTRIBUTION TO THE PATHOGENY OF ARTHRITIS IN RHEUMATIC FEVER
Authors: Harold Kniest Faber
Journal: The Journal of Experimental Medicine (1915)

By a process of sensitization described it was found possible to cause arthritis in rabbits constantly after one intravenous injection of the streptococcus. This reaction is specific. By intravenous inoculation, without previous sensitization, of the streptococcus used in these experiments it was possible to cause arthritis in rabbits only after three or more injections. An analogy is suggested between the arthritis induced by sensitization and the relapses in human rheumatic fever. A further analogy is suggested between the development in rabbits of arthritis after repeated intravenous injections and the development of the primary lesion in human rheumatic fever.
The Icatibant Outcome Survey: Trigger Factors and Premonitory Symptoms of Angioedema Attacks in Patients with Hereditary Angioedema
Authors: Teresa Caballero, Marcus Maurer, Hilary Longhurst, Werner Aberer, Laurence Bouillet, Vincent Fabien, Andrea Zanichelli
Journal: Journal of Allergy and Clinical Immunology (2015)
Generalized heqies simplex infection complicating bullous pemphigoid
Authors: C. Niederecker, G. Tappeiner, K. Wolff
Journal: British Journal of Dermatology (1995)

Journal Article Generalized heqies simplex infection complicating bullous pemphigoid Get access C. Niederecker, C. Niederecker Division of General Dermatology, Department of Dermatology, University of Vienna Medical School, Austria Search for other works by this author on: Oxford Academic Google Scholar G. Tappeiner, G. Tappeiner Division of General Dermatology, Department of Dermatology, University of Vienna Medical School, Austria Search for other works by this author on: Oxford Academic Google Scholar K. Wolff K. Wolff Division of General Dermatology, Department of Dermatology, University of Vienna Medical School, Austria Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 132, Issue 3, 1 March 1995, Pages 484–486, https://doi.org/10.1111/j.1365-2133.1995.tb08691.x Published: 01 March 1995
REPORT OF 661 NAIL PUNCTURE WOUNDS OF THE FOOT
Authors: Fred H. Bowen
Journal: JAMA (1942)

There is a wide diversity of opinion in the literature concerning the proper treatment of nail puncture wounds of the foot. Most authors advocate probing the wound, laying it open, injecting an antiseptic solution (phenol [carbolic acid], tincture of iodine) and instituting some form of drainage. It is my opinion that such treatment is unnecessary, painful and harmful and that it is followed by prolonged disability andat times by a painful plantar scar. Foreign bodies are not often carried deeply into the foot by a nail but they lie in the dermis or just beneath it. I have demonstrated that nails (6 to 20 penny) coated with methylrosaniline (gentian violet) and driven into a cadaver's foot were wiped clean in the proximal 1/4 inch of the tract. In doing a superficial débridement in my cases, I noted that particles of sand were just beneath the epidermis, and occasionally rust
Surgical Fixation of Small Important Bone Fragments with Hookplate
Authors: Wilhelm A. Zuelzer
Journal: JAMA (1960)

The hookplate here described has been used for the surgical fixation of small important bone fragments in 450 cases during the past 12 years. Most of these fragments have been parts of joint structures, the main force of displacement being distraction. This was successfully neutralized with the hookplate, which allows unicortical or bicortical screwfixation at right angles to the distraction force inside the solid cortical bone. There is no force to endanger the stability of this type of fixation. This method has been used in comminuted fractures of the olecranon or of the medial malleolus and fracture-dislocations of the ankle.
Relationship between Extent of Pulmonary Emphysema by High-resolution Computed Tomography and Lung Elastic Recoil in Patients with Chronic Obstructive Pulmonary Disease
Authors: SIMONETTA BALDI, MASSIMO MINIATI, CALOGERO RICCARDO BELLINA, LUIGI BATTOLLA, GIOSUÉ CATAPANO, ENRICO BEGLIOMINI, DAVIDE GIUSTINI, CARLO GIUNTINI
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

We investigated the relationship between the extent of pulmonary emphysema, assessed by quantitative high-resolution computed tomography (HRCT), and lung mechanics in 24 patients with chronic obstructive pulmonary disease (COPD). The extent of emphysema was quantified as the relative lung area with CT numbers < − 950 Hounsfield Units (HU). Patients with COPD had severe airflow obstruction (FEV1 35 ± 15% pred) and severe reduction of CO diffusion constant (Dco/Va 37 ± 19% pred). Maximal static elastic recoil pressure (Pstmax) averaged 54 ± 24% predicted, and the exponential constant K of pressure–volume curves was 258 ± 116% predicted. Relative lung area with CT numbers < − 950 HU averaged 21 ± 11% (range 1 to 38%). It showed a highly significant negative correlation with Dco/Va (r = − 0.84, p < 0.0001), a weak correlation with FEV1% predicted, and no correlation with either Pstmax or constant K. A significant relationship was found between the natural logarithm of K and the full width at half maximum of the frequency distribution of CT numbers, taken as an index of the heterogeneity of lung density (r = 0.68, p < 0.0005). We conclude that currently used methods of assessing the extent of emphysema by HRCT closely reflect the reduction of CO diffusion constant, but cannot predict the elastic properties of the lung tissue.Keywords: Pressure–volume curve; elastic recoil pressure; HRCT quantitative analysis; emphysema heterogeneity
ATRIAL FIBRILLATION IS ASSOCIATED WITH INCREASED MORTALITY IN PATIENTS UNDERGOING TAVR: INSIGHTS FROM THE PARTNER TRIAL
Authors: Angelo Biviano, Jose Dizon, Tamim Nazif, Samir Kapadia, Vasilis Babaliaros, Ke Xu, Josep Rodes-Cabau, Wilson Szeto, William Fearon, Danny Dvir, Todd Dewey, Mathew Williams, Michael Mack, John Webb, D. Craig Miller, Craig Smith, Martin Leon, Susheel Kodali
Journal: Journal of the American College of Cardiology (2014)