Anaphylactoid Reaction Following an Intradermal Test of Tetanus Antitoxin
Authors: ROBERT E. REISMAN
Journal: Annals of Internal Medicine (1963)

Case Studies1 December 1963Anaphylactoid Reaction Following an Intradermal Test of Tetanus AntitoxinROBERT E. REISMAN, M.D., CARL E. ARBESMAN, M.D., F.A.C.P., NOEL R. ROSE, PH.D.ROBERT E. REISMAN, M.D.Search for more papers by this author, CARL E. ARBESMAN, M.D., F.A.C.P.Search for more papers by this author, NOEL R. ROSE, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-59-6-883 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPotential anaphylactoid reactions to horse serum can generally be avoided by prior skin or conjunctival testing. Horse serum products, most frequently tetanus antitoxin, are usually withheld from positive reactors, or, if administered, done so very cautiously. Although serious reactions have occasionally occurred from intradermal testing itself, the immunological pathogenesis of such anaphylactoid reactions has not been thoroughly documented.The following studies give some insight into the mechanisms involved, and also can be contrasted with the previously studied immunopathogenesis of primary serum disease (1-3).CASE HISTORYJ. R., a 20-year-old male college student, lacerated his left palm with a piece of...References1. ARBESMANKANTORROSEWITEBSKY CESZNRE: Serum sickness. J. Allerg. 31: 257, 1960. CrossrefMedlineGoogle Scholar2. REISMANROSEWITEBSKYARBESMAN RENRECE: Serum sickness. II. Demonstration and characteristics of antibodies. J. Allerg. 32: 531, 1961. CrossrefMedlineGoogle Scholar3. ROSEREISMANWITEBSKYARBESMAN NRREECE: Serum sickness. III. Characterization of antigens. J. Allerg. 33: 250, 1962. CrossrefMedlineGoogle Scholar4. DIXONVAZQUEZWEIGLECOCHRANE FJJJWOCG: Immunology and Pathogenesis of Experimental Serum Sickness in Cellular and Humoral Aspects of the Hypersensitive States, ed. by H. SHERWOOD LAWRENCE, Paul B. Hoeber, Inc., New York, 1959, p. 354. Google Scholar5. RICHBERTHRONGBENNETT ARMIL: The effect of cortisone upon the experimental cardiovascular and renal lesions produced by anaphylactic hypersensitivity. Bull. Hopkins Hosp. 87: 549, 1950. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Buffalo, New YorkFrom the Allergy Research Laboratory, Buffalo General Hospital, and the Department of Medicine and of Bacteriology and Immunology, State University of New York at Buffalo, School of Medicine, Buffalo, New York.This work was supported in part by research grant AI 1303 and training grant 2E-51 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.Requests for reprints should be addressed to Robert E. Reisman, M.D., Forty North Street, Buffalo 2, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnaphylactic Deaths: A Clinicopathologic Study of 43 CasesImmunoglobulins and Allergic DiseaseImmunologic Studies in Patients with Serum Sickness-Like Reactions Following Penicillin Therapy**From the Department of Dermatology of the New York University School of Medicine, New York, N.Y. 1 December 1963Volume 59, Issue 6Page: 883-886KeywordsAllergy and immunologyAntitoxinsHospital medicineInfectious diseasesPathogenesisResearch grantsResearch laboratoriesSteroid therapyTetanusUrticaria Issue Published: 1 December 1963 PDF downloadLoading ...