tbuckley/cabot-search huggingface dataset:
Femoral Head Viability Following Hip Fracture Prognostic Role of Radionuclide Bone Imaging
Authors: WALTER E. DRANE, THOMAS G. RUDD
Journal: Clinical Nuclear Medicine (1985)

A retrospective study was made of all radionuclide (RN) bone images performed at our institution over a two-year period to evaluate femoral head viability after nonpathologic fracture of the femoral neck. Twelve patients had avascular femoral heads during the perioperative period, of which nine had adequate follow-up. Seven of these nine patients had follow-up bone images. Revascularization occurred in four patients, while three had persistent absence of femoral head uptake. With clinical follow-up ranging from four to 29 months (median: 14 months), only two of these nine patients developed clinical or radiographic evidence of osteonecrosis. RN bone imaging performed in the perioperative period does not reliably predict the development of post-traumatic osteonecrosis of the femoral head and, at present, should not be used to determine prospectively method of treatment of femoral neck fracture.
A Primer of Water, Electrolyte and Acid-Base Syndromes
Authors: Ronald M. Meyer
Journal: JAMA (1980)

Disorders of fluid-electrolyte and acid-base status occur daily in the inpatient practice of every medical specialty. In the setting of current therapeutics (potent diuretics, parenteral nutrition, dialysis, and cardiovascular, neurological, and transplant surgery), there exist increasing opportunities for life-threatening iatrogenic disorders. With the rapid availability of measurements of blood gas, serum and urine electrolytes, and serum osmolality, comes the opportunity to assess and avoid or treat these most basic derangements of physiology. Unfortunately, medical instruction in fluid-electrolyte and acid-base pathophysiology consists of isolated lectures in physiology and pharmacology courses, followed by "cookbook" presentation of the topic during clerkships in medicine, surgery, and pediatrics. If one is to understand prevention, diagnosis, and therapeutics, self-education is clearly necessary. As a straightforward self-teaching book,<i>A Primer of Water, Electrolyte and Acid-Base Syndromes</i>, recently released in its sixth edition, is well worth its price. Starting with biophysical principles, the author's approach is to present
A Small Town Hero
Authors: Ronald O. Bergom
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Proposed Guidelines on Screening for Risk of Type 1 Diabetes
Authors: Polly J. Bingley, Ezio Bonifacio, Anette-G. Ziegler, Desmond A. Schatz, Mark A. Atkinson, George S. Eisenbarth
Journal: Diabetes Care (2001)

These guidelines represent the recommendations of the Immunology of Diabetes Society (IDS) on the assessment of risk of type 1 diabetes in unaffected first-degree relatives of patients with the disease, and are based on the consensus reached at a symposium held at the fourth meeting of the IDS (Fiuggi, Italy, November 1999).

Assessment of risk of type 1 diabetes in relatives was initially based on detection of circulating islet cell antibodies (ICAs) supplemented by measurement of insulin autoantibodies (IAAs), and evaluation of β-cell function by determination of the first-phase insulin response (FPIR) in the intravenous glucose tolerance test. Other islet autoantigens, including GAD and the protein tyrosine phosphatase IA-2/ICA512, have subsequently been identified, and the role of autoantibodies to these antigens in assessment of risk of type 1 diabetes in first-degree relatives has been investigated in a number of large prospective studies. In addition, the genetic susceptibility to type 1 diabetes, particularly that conferred by genes in the HLA class II region, has been …
THE OPERATIVE TREATMENT OF OTITIC MENINGITIS
Authors: HOLGER MYGIND
Journal: JAMA (1910)

My topic is the operative treatment of otitic meningitis. By meninigitis I mean here diffuse purulent leptomeningitis, that is, an acute inflammation of the soft membranes of the brain which has produced a cerebrospinal fluid varying from being slightly turbid to mere pus, and containing an excess of polynuclear cells. The so-called serous meningitis and the different forms of local meningitis are, therefore, excluded in this paper. The operative treatment of otitic meningitis, in contradistinction to operations for other ototic intracranial complications, has made its way very slowly. It was, as you know, initiated about eleven years ago by Macewen of Glasgow, who, in his excellent work on pyogenic diseases of the brain and the spinal cord, published a report of two cases of otitic meningitis in which operation was successfully performed. I do not think, however, that these were genuine cases of diffuse purulent meningitis. Since then, several surgeons
Neutral endopeptidase 24,11 in polymorphonuclear leukocytes (PMNs) modulates protective effects of natriuretic peptides against PMNs-induced endothelial cytotoxity
Authors: Toshiyuki Matsumura, Kiyotaka Kugiyama, Seigo Sugiyama, Yasuhiro Ogata, Yasutaka Ohta, Hideki Doi, Hirofumi Yasue
Journal: Journal of the American College of Cardiology (1996)
A conversation with Napoleone Ferrara
Authors: Ushma S. Neill
Journal: Journal of Clinical Investigation (2014)

Napoleone Ferrara, of the University of California, San Diego, is best known for isolating and cloning vascular endothelial growth factor (VEGF). He then built the humanized monoclonal antibody against VEGF that led to the blockbuster drugs Avastin (for treating cancer) and Lucentis (for treating wet age-related macular degeneration). The full interview with Napoleone (Figure ​(Figure1)1) can be seen on the JCI website, http://www.jci.org/videos/cgms.
Good Night, Irene
Authors: Michael J. Barry
Journal: Annals of Internal Medicine (2011)

On Being a Doctor1 February 2011Good Night, IreneMichael J. Barry, MDMichael J. Barry, MDFrom Foundation for Informed Medical Decision Making, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02108.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-3-201102010-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Over her 18 years as my patient, Irene was fond of proving me wrong.The latest lesson came just last week. I had seen her recently for a routine visit. She was 87 and came in as usual, bent over her rolling walker, dressed to the nines in pearls, rouge, lipstick, and a trademark enormous bow in her thinning hair. Legally blind owing to macular degeneration, she couldn't quite color “in the lines” with her lipstick, but it was the thought that counted. She came by the MBTA's ride program, which she accepted only after years of urging when she ... Author, Article, and Disclosure InformationAffiliations: From Foundation for Informed Medical Decision Making, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02108.Corresponding Author: Michael J. Barry, MD, Foundation for Informed Medical Decision Making, Massachusetts General Hospital, Harvard Medical School, 40 Court Street, Suite 300, Boston, MA 02108; e-mail, [email protected]org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 2011Volume 154, Issue 3Page: 209-210KeywordsComputed axial tomographyEmotionsFallsFearHallucinationsHematocritHospitalizationsRibsThoraxVision ePublished: 1 February 2011 Issue Published: 1 February 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Social Mission of Medical Education
Authors: Pojen Deng
Journal: Annals of Internal Medicine (2010)

Letters5 October 2010The Social Mission of Medical EducationPojen Deng, BSPojen Deng, BSFrom Providence, RI 02906.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-7-201010050-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with great interest the recent article by Mullan and colleagues (1). I entered medical school with a resolve to plunge into social justice, join Médecins Sans Frontières after graduating, and travel the globe in an effort to eradicate HIV/AIDS. But something unexpected happened during these past 4 years: I found that I enjoyed studying many areas of medicine. My envisioned career was often at odds with every other objective a young person might be expected to have: family, home, and stability. My service-oriented projects, already strung out by my limited time and flexibility, were largely ...Reference1. Mullan F, Chen C, Petterson S, Kolsky G, Spagnola M. The social mission of medical education: ranking the schools. Ann Intern Med. 2010;152:804-11. [PMID: 20547907] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Providence, RI 02906.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Social Mission of Medical Education: Ranking the Schools Fitzhugh Mullan , Candice Chen , Stephen Petterson , Gretchen Kolsky , and Michael Spagnola The Social Mission of Medical Education Fitzhugh Mullan and Candice Chen The Social Mission of Medical Education Eric A. Mellon The Social Mission of Medical Education Scott Barnhart and James LoGerfo The Social Mission of Medical Education Martin Donohoe The Social Mission of Medical Education John A. Brockman , Matthew J. Stull , and Elizabeth Wiley The Social Mission of Medical Education Gregg S. Meyer The Social Mission of Medical Education Norman H. Edelman Metrics 5 October 2010Volume 153, Issue 7Page: 486KeywordsConflicts of interestGraduate medical educationMedical educationPatientsSocial welfare ePublished: 5 October 2010 Issue Published: 5 October 2010 CopyrightCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
The Biologic Basis of Pediatric Practice
Authors: John D. Nelson
Journal: JAMA (1969)

The appearance of this massive work after years of preparation represents a major publishing milestone in pediatrics. It is the stated intent of the editors to relate the basic science aspect of pediatrics to clinical practice, and the book is a natural outgrowth of the expanding, productive basic research in pediatrics. The book is divided into three parts. The first, "Sciences Fundamental to an Understanding of Growth and Maturation," is a pedantically turgid exposition of cell biology, heredity, and the behavioral sciences, too much for a pediatrics book and not enough for a text on cell biology. The second part, "Anatomic and Functional Systems of the Child," forms approximately two thirds of this bulky book. The content corresponds to the standard American textbooks, but the manner of presentation is vastly different. Major emphasis is given to the relation of disease to structure and function, with attention to clinical descriptions. For
Letter: Chronic brucellosis.
Authors: J W Howie
Journal: BMJ (1974)

SiR,-In a letter sent to all doctors and dentists in the United Kingdom on 3 January 1974 the medical assessor for the Committee on Safety of Medicines draws attention to 130 reports concerning jaundice following 'the use of halothane for anaes- thesia.These reports had been volunteered to the comuittee under its usual report- ing procedure for adverse reactions to drugs.He states that the conmittee accepts that the findings of the analysis of these reports
regulation of risks
Authors: paul weirich
Journal: Behavioral and Brain Sciences (2005)

sunstein argues that heuristics misguide moral judgments. principles that are normally sound falter in unusual cases. in particular, heuristics generate erroneous judgments about regulation of risks. sunstein's map of moral reasoning omits some prominent contours. the simple heuristics he suggests neglect a reasoner's attempt to balance the pros and cons of regulating a risk.
814-1 Variations of Segmental Endothelium Dependent and Endothelium Independent Vasomotor Tone in the Long Term Follow Up After Cardiac Transplantation (Qualitative Changes in Endothelial Function)
Authors: Michael Weis, Andreas Hartmann, Nora Marzilli, Hans-Georg Olbrich, Wolfram Burger, Peter Satter
Journal: Journal of the American College of Cardiology (1995)
Mental Retardation: An Atlas of Diseases With Associated Physical Abnormalities
Authors: Samuel A. Shelburne
Journal: JAMA (1972)

This new book on mental retardation emphasizes physical abnormalities associated with various diseases and syndromes. The case material was primarily derived from the Walter E. Fernald State School, Waverly, Mass, and the authors are associated with this institution, the Massachusetts General Hospital, and the Harvard Medical School. The clinical conditions are divided into seven different aspects: metabolic and endocrine diseases, progressive diseases of unknown cause, acquired conditions associated with mental retardation, chromosomal abnormalities, central nervous system malformations, syndromes of multiple deformities, and neurocutaneous syndromes with mental retardation. The illustrations are on the right pages and the text and references are on the left pages. The format is similar to that of two other excellent books,<i>Recognizable Patterns of Human Malformation</i>by D.W. Smith and<i>Atlas of Mental Retardation Syndromes</i>by S.S. Gellis and M. Feingold. The present book is more extensive than the other two publications and in many ways
Systemic Therapy in Patients with Node-Negative Breast Cancer
Authors: Bernard Fisher
Journal: Annals of Internal Medicine (1989)

Objective: To determine whether in the previous National Surgical Adjuvant Breast and Bowel Project (NSABP) studies of node-negative breast cancer there were either cohorts of patients with a prognosis favorable enough to preclude using systemic therapy or subsets of patients who failed to benefit from the treatments. Design: Randomized clinical trials with stratification after surgery. Setting: NSABP trials at institutions in the United States and Canada. Patients: Data were collected on 731 eligible patients (Protocol B-13) with estrogen-receptor-negative tumors who randomly received either no therapy after surgery or sequential methotrexate and fluorouracil (M → F) followed by leucovorin. Data were also collected on 2834 patients (Protocol B-14) with estrogen-receptor-positive tumors who randomly received either placebo or tamoxifen treatment. The percentage of patients surviving disease-free was determined through 4 years of follow-up using life-table estimates. Interventions: Protocol B-13 patients received 12 courses of M → F given intravenously on days 1 and 8 every 4 weeks. Leucovorin therapy was begun 24 hours after M → F administration. Protocol B-14 patients received 5-year treatment with either tamoxifen (10 mg twice daily by mouth) or placebo. Results: When the outcome of untreated patients in either trial was related to the stratification variables, women were found to have a disease-free survival of less than 80% through 4 years of follow-up. This percentage is apt to decrease because the probability of treatment failure increases with time. In both trials, all subsets of women benefited from M → F or tamoxifen therapy. Conclusions: The disease-free survival of all cohorts of node-negative patients with estrogen-receptor-negative or estrogen-receptor-positive tumors was poor enough to justify systemic treatment. The benefits of the therapies used are insufficient to eliminate the need for assessing putatively better regimens.
Searching for our moral roots.
Authors: J Habgood
Journal: BMJ (1986)

5 Hatch S, Hin ton T. Self-help in practice: a study of Contact a Family, community work, and family support. Sheffield: Joint Unit for Social Services Research, 1986. 6 Laurier J. Self-help society for eczema sufferers and their families. BrMedJ 1976;ii: 1494-5. 7 Robinson D, Robinson Y. From self-help to health. London: Concord Books, 1979. 8 Alexander NB. Self-help groups: part 1. Clin Gastroenterol 1982;11:405-14. 9 Jenchs (1976). Cited by Webb PA. Ready, willing but able? The self-help group. Journal of the Royal Society of Health 1983;January:35-41. 10 Clement-Jones V. Cancer and beyond: the formation of BACUP. BrMedJ 1985;291:1021-3. 11 Littlewood J. Asthma?a support group. Nursing Times 1984 August 1:40-2. 12 Vandrik IH, Storhaug K. Family-focused services for children with rare disorder, exemplified by bladder exstrophy. ClinPediatr(Phila) 1985;24:97-100. 13 Webb PA, Ready, willing but able? The self-help group. Journal of the Royal Society of Health 1983;January:35-41. 14 Hatch S. Participation in health. In: Maxwell R, Weaver N, eds. Public participation in health. London: King's Fund, 1984. 15 Melville J. Careless. Guardian 1982 April 21:17. 16 Bolt J, Perrins DJD, Webster C. Hyperbaric oxygen in multiple sclerosis. BrMedJ 1986;292:691. 17 James PB. Hyperbaric oxygen in multiple sclerosis. BrMedJ 1986;292:691. 18 Gann R. The health information handbook. Aldershot: Go wer, 1986. 19 James PB. Self-help groups: part 2. Clin Gastroenterol 1982;11:415-9. 20 Anonymous. Consensus development conference: treatment of primary breast cancer. BrMedJ 1986;293:946-7.
Relationship of insulin binding and insulin-stimulated tyrosine kinase activity is altered in type II diabetes.
Authors: R J Comi, G Grunberger, P Gorden
Journal: Journal of Clinical Investigation (1987)

The insulin receptor contains an alpha subunit with insulin binding properties and a beta subunit with insulin-stimulated tyrosine kinase function. Preparations containing insulin and insulinlike growth factor I (IGF-I) receptors were obtained from solubilized human red cell membranes by affinity chromatography. After separate assays for insulin binding and insulin-stimulated tyrosine kinase activities, a high degree of correlation was found between these activities in preparations from normals and diabetics. Identical studies using IGF-I as the ligand showed a lesser degree of correlation. We compared 24 normal subjects and 14 untreated type II diabetics and found significant diminution in the slope of the line coupling insulin binding and insulin-stimulated kinase activities in the diabetics. This difference was not observed in a similar study of IGF-I-related activities. Compared to normal controls, untreated type II diabetics have reduced tyrosine kinase activity stimulated per unit insulin binding.
Study of protein characteristics that influence entry into the cerebrospinal fluid of normal mice and mice with encephalitis.
Authors: D E Griffin, J Giffels
Journal: Journal of Clinical Investigation (1982)

Entry of proteins into the cerebrospinal (CSF) from the blood is partially determined by the size of the protein. To determine whether other characteristics of proteins influence CSF entry, proteins or protein fragments were iodinated, inoculated intravenously, and serum and CSF were sampled at later times. The Fc fragment of immunoglobulin G (IgG) did not enter the CSF significantly better than the Fab fragment suggesting that choroidal Fc receptors are not of importance for selective immunoglobulin entry. To determine the role of protein charge on entry, bovine serum albumin [isoelectric point (pI) = 3.9] was chemically altered to provide an albumin with an average pI of 6 (A-6) and another with a pI of 8.5 (A-8). All albumins were of the same size on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A-8 entered the CSF approximately 10-fold better than the native albumin. A-6 was intermediate, entering approximately twofold better. At the time of increased CSF protein concentration during an acute viral encephalitis these differences were narrowed but not eliminated. It is concluded that charge is an important determinant of protein entry into the CSF.
Medical Technology — A Different View of the Contentious Debate over Costs
Authors: Thomas W. Moloney, David E. Rogers
Journal: New England Journal of Medicine (1979)

There is a growing conviction that medical technologies are major contributors to escalating costs, and regulating them is generally viewed as the least contentious way to control expenses in the 1980's. Five forms of technology control are being discussed or developed. All aim to reduce costs by controlling big, expensive technologies in the class of computed tomographic (CT) scanning. We present evidence that technologies such as the CT scanner account for far less of the growth in medical expenditures than do the collective expenses of thousands of small tests and procedures. Furthermore, we suggest that each strategy for controlling large technology involves substantial practical and conceptual problems that would severely limit its effectiveness. We thus suggest a shift away from attempts to harness the big technologies, and toward incentives to encourage the more discerning use of all technologies. To this end, we propose changes in physician reimbursement and education and expanded insurance incentives to encourage physicians and hospitals to be more selective in the use of technology.
A President's Assassination
Authors: Ralph L. Stevens
Journal: JAMA (1981)

In view of our 40th president's recent brush with death, it is interesting to recall the assassination of our 20th president, James Garfield, exactly a century ago in 1881. James Abram Garfield was elected President of the United States in 1880; like Ronald Reagan he was a Republican and a vigorous, healthy man, standing nearly 6 feet tall and weighing 210 lb. On the morning of July 2, 1881, Garfield was shot in the back by an assassin in the Washington, DC, train station. Eyewitnesses described the ensuing scene as one of "the greatest confusion and terror.... Soon the doors were shut to keep out the excited crowd, surgical aid called for the President, and the assassin hurried away to jail." Garfield's assassin, Charles Guiteau, was nearly killed by one of his prison guards and survived only because his cell bars deflected the bullet fired at him.<sup>1</sup> When Dr
How many consultants should you invite to a meeting to ensure it will never happen?
Authors: D. P. Francis
Journal: BMJ (2010)

Meetings can be difficult to arrange for executives in any walk of life, but for consultants in Britain’s National Health Service, the mathematics is uniquely easy.

UK NHS contracts are typically 75% direct clinical care—contact with patients during sessions in the outpatient department, on ward rounds, in the operating theatre, or in laboratories when patients are undergoing diagnostic tests. The remaining 25% of the time is for supporting professional activities, including reading and writing correspondence, speaking with general practitioners and other specialists, teaching and training junior doctors and medical students, reading and writing scientific literature, etc. For a one-off meeting between consultants, it is undesirable to cancel or delay a …