tbuckley/cabot-search huggingface dataset:
The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activity.
Authors: Dan Qiao, Lyudmila A Nikitina, Gennady A Buznikov, Jean M Lauder, Frederic J Seidler, Theodore A Slotkin
Journal: Environmental Health Perspectives (2003)

Embryonic development in the sea urchin requires trophic actions of the same neurotransmitters that participate in mammalian brain assembly. We evaluated the development of the high-affinity choline transporter, which controls acetylcholine synthesis. A variety of developmental neurotoxicants affect this transporter in mammalian brain. [3H]Hemicholinium-3 binding to the transporter was found in the cell membrane fraction at stages from the unfertilized egg to pluteus, with a binding affinity comparable with that seen in mammalian brain. Over the course of development, the concentration of transporter sites rose more than 3-fold, achieving concentrations comparable with those of cholinergically enriched mammalian brain regions. Dimethylaminoethanol (DMAE), a competitive inhibitor of choline transport, elicited dysmorphology beginning at the mid-blastula stage, with anomalies beginning progressively later as the concentration of DMAE was lowered. Pretreatment, cotreatment, or delayed treatment with acetylcholine or choline prevented the adverse effects of DMAE. Because acetylcholine was protective at a lower threshold, the DMAE-induced defects were most likely mediated by its effects on acetylcholine synthesis. Transient removal of the hyaline layer enabled a charged transport inhibitor, hemicholinium-3, to penetrate sufficiently to elicit similar anomalies, which were again prevented by acetylcholine or choline. These results indicate that the developing sea urchin possesses a high-affinity choline transporter analogous to that found in the mammalian brain, and, as in mammals, the functioning of this transporter plays a key role in the developmental, trophic activity of acetylcholine. The sea urchin model may thus be useful in high-throughput screening of suspected developmental neurotoxicants.
Casualties in the South Pacific
Authors: H. E. Kennard
Journal: New England Journal of Medicine (1945)

Twenty months' duty in the Southwest Pacific gave me the opportunity to see and participate in the care of many war wounded. The first fourteen months were passed in New Zealand, following which a transfer northward brought my unit close enough to the Solomon Islands campaign to receive battle casualties from there by air.Duty in New Zealand was very pleasant. The country is roughly a thousand miles long and one to two hundred miles wide. It is made up of two large islands, with a narrow strait between. The total population is only 1,600,000. The climate is delightful. It . . .
Oral contraceptive use and venous thromboembolism: absence of an effect of smoking.
Authors: D H Lawson, J F Davidson, H Jick
Journal: BMJ (1977)

Medical and environmental surveys were conducted at a wollastonite mine and mill in 1976 and in 1982. Health testing included chest radiography, spirometry, and a questionnaire. Workers at a nearby electronics plant were also examined in 1982 for a comparison of lung function and respiratory symptoms. Both wollastonite and control workers showed significant smoking effects for chronic respiratory symptoms, but differences between the groups were not detected. Pneumoconiosis was found in 3% (3/108) of the wollastonite workers in 1982, but none showed a significant progression from their 1976 radiographs. The lung function tests of the 108 wollastonite workers examined in 1982 showed dust related changes in FEV1, FEV1/FVC ratio, and peak flow rate which were independent of age, height, and smoking habit (p less than 0.01). For non-smokers alone, only the FEV1/FVC ratio declined significantly with dust-years of exposure (p less than 0.01). The comparison of lung function in 1982 between a high dust exposed subgroup of wollastonite workers and the control population showed a significantly lower FEV1/FVC ratio and peak flow rate in the study group (p less than 0.05). Analysis of 1976-82 changes in pulmonary function showed that wollastonite workers with higher dust exposure had a significantly greater decline in peak flow over the period than workers with lower exposures (p less than 0.01). These data suggest that long term cumulative exposure to wollastonite may impair ventilatory capacity as reflected by changes in the FEV1/FVC ratio and peak flow rate.
Acquired erythropoietic protoporphyria as a result of myelodysplasia causing loss of chromosome 18
Authors: R.P.E. Sarkany, G. Ross, F. Willis
Journal: British Journal of Dermatology (2006)

We report a patient aged 73 years, who developed erythropoietic protoporphyria with typical photosensitivity, at the same time as she was diagnosed as having myelodysplastic syndrome. The myelodysplastic clone in her bone marrow completely lacked one of the two copies of chromosome 18. As chromosome 18 is the locus of the ferrochelatase gene, we postulate that this chromosomal deletion led to reduced synthesis of the enzyme in the bone marrow clone, so causing the porphyria. The nature of the remaining ferrochelatase allele was examined by polymorphism analysis and we discuss the insights that this patient's genotype may reveal about the pathogenesis of porphyria in myelodysplasia.
Gallbladder Carcinoma
Authors: M G VELCHIK, P T MAKLER, A ALAVI
Journal: Clinical Nuclear Medicine (1984)

A case report of an 82-year-old woman with carcinoma of the gallbladder is presented. Technetium-99m DISIDA cholescintigraphy demonstrated nonvisualization of the gallbladder, with a large photon-deficient region corresponding to the gallbladder fossa, with medial displacement of the common bile duct. Carcinoma of the gallbladder has not been previously described as a cause of this scintigraphic pattern.
DERMATOLOGISTS AT UNIVERSTY COLLEGE HOSPITAL.
Authors: A. M. H. GRAY
Journal: British Journal of Dermatology (1963)

Journal Article DERMATOLOGISTS AT UNIVERSTY COLLEGE HOSPITAL. Get access A. M. H. GRAY, K.C.V.O Sir A. M. H. GRAY, K.C.V.O Sir Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 75, Issue 12, 1 December 1963, Pages 457–464, https://doi.org/10.1111/j.1365-2133.1963.tb13928.x Published: 01 December 1963
Review: Early treatment of a cardiovascular event with nitrates or ACE inhibitors reduces short-term mortality
Authors: Jason Bradfield, Kalyanam Shivkumar
Journal: Annals of Internal Medicine (2010)

Source Citation Perez MI, Musini VM, Wright JM. Effect of early treatment with anti-hypertensive drugs on short and long-term mortality in patients with an acute cardiovascular event. Cochrane Database Syst Rev. 2009;(4):CD006743. 19821384
Comment on: Jeon et al. <i>Helicobacter pylori</i> Infection Is Associated With an Increased Rate of Diabetes. Diabetes Care 2012;35:520–525
Authors: Ahad Eshraghian, Rinaldo Pellicano
Journal: Diabetes Care (2012)

We read with great interest the article by Jeon et al. (1) who, in a prospective cohort study (Sacramento Area Latino Study on Aging), showed that Helicobacter pylori ( H. pylori ) infection was associated with increased incidence of diabetes. Although these findings are very interesting, they should be interpreted with caution, and some points should be discussed. The first issue is that the study participants were elderly with a mean age of 68.7 years. It is well known that both incidence of diabetes and H. pylori seropositivity increase in older individuals (2). Thus, …
Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols
Authors: Wipob Suttana, Samlee Mankhetkorn, Wilart Poompimon, Ajay Palagani, Sergey Zhokhov, Sarah Gerlo, Guy Haegeman, Wim Vanden Berghe
Journal: Molecular Cancer (2010)

Abstract Background Multidrug resistance (MDR) is a major obstacle in cancer treatment and is often the result of overexpression of the drug efflux protein, P-glycoprotein (P-gp), as a consequence of hyperactivation of NFκB, AP1 and Nrf2 transcription factors. In addition to effluxing chemotherapeutic drugs, P-gp also plays a specific role in blocking caspase-dependent apoptotic pathways. One feature that cytotoxic treatments of cancer have in common is activation of the transcription factor NFκB, which regulates inflammation, cell survival and P-gp expression and suppresses the apoptotic potential of chemotherapeutic agents. As such, NFκB inhibitors may promote apoptosis in cancer cells and could be used to overcome resistance to chemotherapeutic agents. Results Although the natural withanolide withaferin A and polyphenol quercetin, show comparable inhibition of NFκB target genes (involved in inflammation, angiogenesis, cell cycle, metastasis, anti-apoptosis and multidrug resistance) in doxorubicin-sensitive K562 and -resistant K562/Adr cells, only withaferin A can overcome attenuated caspase activation and apoptosis in K562/Adr cells, whereas quercetin-dependent caspase activation and apoptosis is delayed only. Interestingly, although withaferin A and quercetin treatments both decrease intracellular protein levels of Bcl2, Bim and P-Bad, only withaferin A decreases protein levels of cytoskeletal tubulin, concomitantly with potent PARP cleavage, caspase 3 activation and apoptosis, at least in part via a direct thiol oxidation mechanism. Conclusions This demonstrates that different classes of natural NFκB inhibitors can show different chemosensitizing effects in P-gp overexpressing cancer cells with impaired caspase activation and attenuated apoptosis.
Proliferation-associated differences in the spatial and temporal expression of gap junction genes in rat liver
Authors: Mark J. Neveu, James R. Hully, Karlee L. Babcock, Jennifer Vaughan, Elliot L. Hertzberg, Bruce J. Nicholson, David L. Paul, Henry C. Pitot
Journal: Hepatology (1995)

After a 70% partial hepatectomy (PH), the steady-state levels of Connexin (Cx)32, Cx26, and Cx43 messenger RNA (mRNA) transcripts each displayed unique patterns of temporal expression. Within 1 hour after surgical resection, increased expression of all three Cx mRNAs was observed. Subsequently, the level of Cx32 mRNA transcripts transiently decreased to a nadir at 12 hours. Comparisons of the spatial changes with previously reported hepatocyte proliferation kinetics induced by PH demonstrated that hepatocytes before S-phase "remodel" their GJs. Within 1 to 5 hours post-PH, midzonal hepatocytes exhibited diffuse membrane staining different from the normal punctate distribution. Subsequently, midzonal hepatocytes expressed colocalized punctate Cx32 and Cx26 immunostaining. Because the changes occurred in midzonal hepatocytes before 24 hours post-PH, near the peak of hepatocyte DNA synthesis, these findings indicate that Cx26 is enhanced in hepatocytes before the onset of S-phase. In contrast to the restricted expression of Cx43 in Glisson's capsule in adult liver, Cx43 protein and mRNA were enhanced specifically in proliferating bile duct and perisinusoidal cells post-PH. PH performed during continuous administration of 2-acetylaminofluorene (AAF) prevented changes in Cx32 and Cx26 staining observed in the absence of AAF. Proliferating oval cells were found to express diffuse Cx43 immunoreactivity. On day 11 post-PH and AAF, basophilic hepatocytes displayed both punctate Cx32 and Cx26 staining, whereas bile ducts and perisinusoidal cells expressed Cx43. These findings indicate that alterations in Cx32 and Cx26 expression occur rapidly in hepatocytes stimulated to proliferate and that several nonparenchymal liver cell types upregulate Cx43 expression when induced to proliferate. Differentiation of oval cells into basophilic hepatocytes resulted in their expression of Cx32 and Cx26.
Treatment of low back pain by acupressure and physical therapy: randomised controlled trial
Authors: Lisa Li-Chen Hsieh, Chung-Hung Kuo, Liang Huei Lee, Amy Ming-Fang Yen, Kuo-Liong Chien, Tony Hsiu-Hsi Chen
Journal: BMJ (2006)

<h3>Abstract</h3> <b>Objective</b> To evaluate the effectiveness of acupressure in terms of disability, pain scores, and functional status. <b>Design</b> Randomised controlled trial. <b>Setting</b> Orthopaedic clinic in Kaohsiung, Taiwan. <b>Participants</b> 129 patients with chronic low back pain. <b>Intervention</b> Acupressure or physical therapy for one month. <b>Main outcome measures</b> Self administered Chinese versions of standard outcome measures for low back pain (primary outcome: Roland and Morris disability questionnaire) at baseline, after treatment, and at six month follow-up. <b>Results</b> The mean total Roland and Morris disability questionnaire score after treatment was significantly lower in the acupressure group than in the physical therapy group regardless of the difference in absolute score (- 3.8, 95% confidence interval - 5.7 to - 1.9) or mean change from the baseline (- 4.64, - 6.39 to - 2.89). Acupressure conferred an 89% (95% confidence interval 61% to 97%) reduction in significant disability compared with physical therapy. The improvement in disability score in the acupressure group compared with the physical group remained at six month follow-up. Statistically significant differences also occurred between the two groups for all six domains of the core outcome, pain visual scale, and modified Oswestry disability questionnaire after treatment and at six month follow-up. <b>Conclusions</b> Acupressure was effective in reducing low back pain in terms of disability, pain scores, and functional status. The benefit was sustained for six months.
Regulation of mucociliary clearance in health and disease
Authors: E. Houtmeyers, R. Gosselink, G. Gayan-Ramirez, M. Decramer
Journal: European Respiratory Journal (1999)

Airway secretions are cleared by mucociliary clearance (MCC), in addition to other mechanisms such as cough, peristalsis, two-phase gas-liquid flow and alveolar clearance. MCC comprises the cephalad movement of mucus caused by the cilia lining the conducting airways until it can be swallowed or expectorated. MCC is a very complex process in which many variables are involved, all of which may modify the final outcome. The structure, number, movement and co-ordination of the cilia present in the airways as well as the amount, composition and rheological properties of the periciliary and mucus layers are determinants of MCC. Physiological factors such as age, sex, posture, sleep and exercise are reported to influence MCC due to a change in the cilia, the mucus or the periciliary layer, or a combination of these. Environmental pollution is suspected to have a depressant effect on MCC dependent on different factors such as pollutant concentration and the duration of exposure. Most studies focus on sulphur dioxide, sulphuric acid, nitrogen dioxide and ozone. Tobacco smoke and hairspray have been noted to have a negative influence on MCC. Some diseases are known to affect MCC, mostly negatively. The underlying mechanism differs from one illness to another. Immotile cilia syndrome, asthma, bronchiectasis, chronic bronchitis, cystic fibrosis and some acute respiratory tract infections are among the most frequently reported. The present paper reviews normal mucociliary clearance and the effects of diseases on this process.
A Medical Poet of the Middle Border, William Savage Pitts, M.D.
Authors: LOUIS H. RODDIS
Journal: Annals of Internal Medicine (1933)

Article1 January 1933A Medical Poet of the Middle Border, William Savage Pitts, M.D.LOUIS H. RODDISLOUIS H. RODDISSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-7-952 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere are numerous English and American poets whose works are voluminous and who like Shakespeare, Milton, Byron and Longfellow are as notable for the quantity as for the quality of their verse. On the other hand there are not a few who owe their fame to almost a single song. Such are Gray with the "Elegy Written in a Country Churchyard", Cooke whose "Florence Vane" has been translated into more modern languages than there are verses in the poem, Lady Scott's "Annie Laurie", Foster's "Swanee River", and Payne's "Home, Sweet Home". In these latter the wedding of words and music... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medical Corps United States NavyReceived for publication, July 5, 1932.Note by Editor: This is the fourth in a series of sketches of medical poets by the author. The subjects of those preceding were Joseph Rodman Drake, Oliver Wendell Holmes, and Oliver Goldsmith. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1933Volume 6, Issue 7Page: 952-958KeywordsRivers Issue Published: 1 January 1933 PDF DownloadLoading ...
Mutations in the nervous system–specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II
Authors: Masoud Shekarabi, Nathalie Girard, Jean-Baptiste Rivière, Patrick Dion, Martin Houle, André Toulouse, Ronald G. Lafrenière, Freya Vercauteren, Pascale Hince, Janet Laganiere, Daniel Rochefort, Laurence Faivre, Mark Samuels, Guy A. Rouleau
Journal: Journal of Clinical Investigation (2008)

Hereditary sensory and autonomic neuropathy type II (HSANII) is an early-onset autosomal recessive disorder characterized by loss of perception to pain, touch, and heat due to a loss of peripheral sensory nerves. Mutations in hereditary sensory neuropathy type II (HSN2), a single-exon ORF originally identified in affected families in Quebec and Newfoundland, Canada, were found to cause HSANII. We report here that HSN2 is a nervous system-specific exon of the with-no-lysine(K)-1 (WNK1) gene. WNK1 mutations have previously been reported to cause pseudohypoaldosteronism type II but have not been studied in the nervous system. Given the high degree of conservation of WNK1 between mice and humans, we characterized the structure and expression patterns of this isoform in mice. Immunodetections indicated that this Wnk1/Hsn2 isoform was expressed in sensory components of the peripheral nervous system and CNS associated with relaying sensory and nociceptive signals, including satellite cells, Schwann cells, and sensory neurons. We also demonstrate that the novel protein product of Wnk1/Hsn2 was more abundant in sensory neurons than motor neurons. The characteristics of WNK1/HSN2 point to a possible role for this gene in the peripheral sensory perception deficits characterizing HSANII.
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line
Authors: Harukazu Suzuki, Alistair R.R. Forrest, Erik Van Nimwegen, Carsten O. Daub, Piotr J. Balwierz, Katharine M. Irvine, Timo Lassmann, Timothy Ravasi, Yuki Hasegawa, Michiel J.L. De Hoon, Shintaro Katayama, Kate Schroder, Piero Carninci, Yasuhiro Tomaru, Mutsumi Kanamori-Katayama, Atsutaka Kubosaki, Altuna Akalin, Yoshinari Ando, Erik Arner, Maki Asada, Hiroshi Asahara, Timothy Bailey, Vladimir B. Bajic, Denis Bauer, Anthony G. Beckhouse, Nicolas Bertin, Johan Björkegren, Frank Brombacher, Erika Bulger, Alistair M. Chalk, Joe Chiba, Nicole Cloonan, Adam Dawe, Josee Dostie, Pär G. Engström, Magbubah Essack, Geoffrey J. Faulkner, J. Lynn Fink, David Fredman, Ko Fujimori, Masaaki Furuno, Takashi Gojobori, Julian Gough, Sean M. Grimmond, Mika Gustafsson, Megumi Hashimoto, Takehiro Hashimoto, Mariko Hatakeyama, Susanne Heinzel, Winston Hide, Oliver Hofmann, Michael Hörnquist, Lukasz Huminiecki, Kazuho Ikeo, Naoko Imamoto, Satoshi Inoue, Yusuke Inoue, Ryoko Ishihara, Takao Iwayanagi, Anders Jacobsen, Mandeep Kaur, Hideya Kawaji, Markus C. Kerr, Ryuichiro Kimura, Syuhei Kimura, Yasumasa Kimura, Hiroaki Kitano, Hisashi Koga, Toshio Kojima, Shinji Kondo, Takeshi Konno, Anders Krogh, Adele Kruger, Ajit Kumar, Boris Lenhard, Andreas Lennartsson, Morten Lindow, Marina Lizio, Cameron MacPherson, Norihiro Maeda, Christopher A. Maher, Monique Maqungo, Jessica Mar, Nicholas A. Matigian, Hideo Matsuda, John S. Mattick, Stuart Meier, Sei Miyamoto, Etsuko Miyamoto-Sato, Kazuhiko Nakabayashi, Yutaka Nakachi, Mika Nakano, Sanne Nygaard, Toshitsugu Okayama, Yasushi Okazaki, Haruka Okuda-Yabukami, Valerio Orlando, Jun Otomo, Mikhail Pachkov, Nikolai Petrovsky, Charles Plessy, John Quackenbush, Aleksandar Radovanovic, Michael Rehli, Rintaro Saito, Albin Sandelin, Sebastian Schmeier, Christian Schönbach, Ariel S. Schwartz, Colin A. Semple, Miho Sera, Jessica Severin, Katsuhiko Shirahige, Cas Simons, George St. Laurent, Masanori Suzuki, Takahiro Suzuki, Matthew J. Sweet, Ryan J. Taft, Shizu Takeda, Yoichi Takenaka, Kai Tan, Martin S. Taylor, Rohan D. Teasdale, Jesper Tegnér, Sarah Teichmann, Eivind Valen, Claes Wahlestedt, Kazunori Waki, Andrew Waterhouse, Christine A. Wells, Ole Winther, Linda Wu, Kazumi Yamaguchi, Hiroshi Yanagawa, Jun Yasuda, Mihaela Zavolan, David A. Hume, Takahiro Arakawa, Shiro Fukuda, Kengo Imamura, Chikatoshi Kai, Ai Kaiho, Tsugumi Kawashima, Chika Kawazu, Yayoi Kitazume, Miki Kojima, Hisashi Miura, Kayoko Murakami, Mitsuyoshi Murata, Noriko Ninomiya, Hiromi Nishiyori, Shohei Noma, Chihiro Ogawa, Takuma Sano, Christophe Simon, Michihira Tagami, Yukari Takahashi, Jun Kawai, Yoshihide Hayashizaki
Journal: Nature Genetics (2009)
PREGNANCY AFTER TRANSLAPAROSCOPIC ZYGOTE INTRAFALLOPIAN TRANSFER IN A PATIENT WITH SPERM ANTIBODIES
Authors: Paul Devroey, Paul Braeckmans, Johan Smitz, LindaVan Waesberghe, Arjoko Wisanto, Andrévan Steirteghem, Luc Heytens, Fréderic Camu
Journal: The Lancet (1986)
PRIMARY CARCINOMA OF THE BRONCHI
Authors: THOMAS McCRAE
Journal: JAMA (1927)

Malignant disease of the lung, including the bronchi, is steadily assuming greater importance as the result probably both of increased frequency and of more accurate diagnosis. It is important that the effort should be made to increase our knowledge of the subject in the hope that early diagnosis and proper treatment may reduce the mortality. This hope must be concerned particularly with neoplasms originating in one part; namely, in the bronchus. The term "carcinoma of the lung" suggests a neoplasm of the lung tissue proper, but new growths originating in the lung parenchyma comprise only a small proportion of all lung tumors (perhaps from 10 to 15 per cent). The great majority originate in the bronchi and subsequently invade the lung tissue. It is therefore with neoplasms originating in the bronchi that we are particularly concerned. The main points that we shall discuss are (1) the question of increase in
Discoid lupus erythematosus successfully treated by photodynamic therapy
Authors: A. Debu, C. Girard, D. Bessis
Journal: British Journal of Dermatology (2014)

Journal Article Discoid lupus erythematosus successfully treated by photodynamic therapy Get access A. Debu, A. Debu Department of Dermatology INSERM 1058 and University of Montpellier I Montpellier France Search for other works by this author on: Oxford Academic Google Scholar C. Girard, C. Girard Department of Dermatology INSERM 1058 and University of Montpellier I Montpellier France Search for other works by this author on: Oxford Academic Google Scholar D. Bessis D. Bessis Department of Dermatology INSERM 1058 and University of Montpellier I Montpellier France Correspondence: Didier Bessis. E‐mail: d-bessis@chu-montpellier.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 3, 1 March 2015, Pages 821–822, https://doi.org/10.1111/bjd.13407 Published: 01 March 2015