tbuckley/cabot-search huggingface dataset:
Intraepithelial Endocrine Cell Population in Larynx from Ovalbumin (OVA) Sensitized and Orally Challenged Rabbits
Authors: M.A. Vinuesa, N.D. Bassan, G.H. Fontanella, S. Chaparro, N. Caviglia, G. Kieffer
Journal: Journal of Allergy and Clinical Immunology (2006)
GP funding formula masks major inequalities for practices in deprived areas
Authors: K. Boomla, S. Hull, J. Robson
Journal: BMJ (2014)

Appleby reminds us that general practice funding has fallen to 8% of total NHS spending.1 But his analysis masks the important point that differing population needs greatly affect practice workload.

The 2004 Carr-Hill funding formula had the laudable aim of allocating funds to reflect the workload requirements of each practice population. Reliable data on the workload implications of social deprivation were unavailable, and the resulting formula did not redress the health burden of inequality, as shown …
GMC was wrong to suspend obstetrician four years after baby died
Authors: C. Dyer
Journal: BMJ (2008)

An obstetrician has won a High Court ruling quashing a “flawed” General Medical Council decision that his fitness to practice was impaired in 2007 because of failings four years earlier when a baby died.

The GMC panel found in October 2007 that Hassam Azzam, when a specialist registrar in obstetrics and gynaecology at South Tyneside General Hospital in September 2003, was guilty of “inappropriate, inadequate, and irresponsible” conduct in failing to arrange the immediate delivery of a 19 year old woman’s baby after reading a “pathological” cardiotocography trace. 

The GMC also found Dr Azzam to have behaved irresponsibly in failing to attach a fetal scalp electrode, omitting to review the mother within 30 minutes, and failing to ensure that his replacement, who had come on duty, was aware of the seriousness of the situation.

But …
SOME CASES OF TUBERCULAR MENINGITIS.
Authors: ANNIE S. DANIEL
Journal: JAMA (1897)

Since the first description of tubercular meningitis by Whyt, in 1768, the disease has been studied and described by a legion of authors, and yet today the most experienced diagnostician finds difficulty in arriving at a correct, early diagnosis. The invariable fatality of the disease is recognized both by parents and physicians and increases the obligation of not regarding the early symptoms of no importance, or ascribing them to a gastric catarrh or nervousness. Fortunately, the life of the patient does not depend on an early recognition of the disease, for as yet no remedy has been discovered which if given either early or late in the disease can in any way affect its course. We can not depend on one symptom, but rather on a group, of at times irregular symptoms, to base a diagnosis. The younger the child the greater difficulty. A known exposure to tubercular infection or
Carrel: a personal reminiscence
Authors: R. J. Bing
Journal: JAMA (1983)

RECENTLY there has been a revival of interest in Alexis Carrel, the French-born surgeon, who performed his greatest work in this country and died at the end of World War II in Paris. Several biographies have appeared in book form, and a series of articles on his work has been recently published. They all describe Carrel's research and his accomplishments as an experimental surgeon and as a biologist. However, little has been written about the man himself. It may be said that it is not necessary to describe a great man's personality—his relationship to others, his co-workers, his friends—his work is the sum total of everything, and nothing else matters. It even has been claimed that the best biographies are written by those who never even encountered their subject in the flesh. This may be true, if only his work is discussed, but such a picture is limited and is
Chronic parvovirus infection and G6PD deficiency masquerading as Diamond-Blackfan anemia
Authors: Samir Parekh, Alejandra Perez, Xiao Yan Yang, Henny Billett
Journal: American Journal of Hematology (2005)

Bone marrow aplasia due to parvovirus B19 infections is usually mild and self-limited. In patients with hereditary or acquired hemolytic anemias, B19 infection can cause a severe and life-threatening anemia due to the shortened half-life of red cells, but here, too, the transient nature of the infection soon remits the symptoms. Chronic infections with parvovirus are more characteristically associated with immunodeficiency states. We report here a case of B19-induced anemia in a patient with G6PD deficiency and hypogammaglobulinemia which was mislabeled as Diamond–Blackfan anemia until the use of modern laboratory techniques allowed a correct diagnosis to be made. Am. J. Hematol. 79:54–57, 2005. © 2005 Wiley-Liss, Inc.
Delayed non-mycotic false aneurysm of ascending aortic cannulation site.
Authors: A S Soorae, J Cleland, H O'Kane
Journal: Thorax (1977)

Two cases of delayed non-mycotic false aneurysm arising from ascending aortic cannulation site, presenting one-and-a-hald years and seven years after cardiopulmonary bypass, are described. These two cases represent an incidence of 0.12% of this complication. Repair using profound hypothermia and circulatory arrest with femoral artery and femoral vein cannulation for cardiopulmonary bypass is recommended. The advantages and complications of aortic cannulation are discussed and recommendations to minimise the complications of cannulation are made. The clinical presentation and diagnosis of non-mycotic false aneurysms arising from the aortic cannulation site are described. In addition one delayed and two early cases of non-mycotic cannulation site false aneurysms previously published are analysed. Surgeons should be alert to the possibility of this complication in all patients who have had aortic cannulation for cardiopulmonary bypass even in the distant past. Unexpected symptoms such as constant anterior chest pain, dysphagia, hoarseness, and increasing widening of the superior mediastinum on the chest radiograph warrant prompt investigation.
Trust challenges ruling over sectioning patients
Authors: C. Dyer
Journal: BMJ (1998)

Five law lords were asked last week to overturn a Court of Appeal ruling which has forced doctors to section tens of thousands of patients under the Mental Health Act.

Bournewood Community and Mental Health Trust in Surrey, backed by the Department of Health, launched a test case to challenge the ruling, which has huge resource implications for the NHS. It means that tens of thousands of patients with dementia and learning disabilities who under previous practice were admitted informally have had to be assessed and many of them detained compulsorily under the Act.

Three appeal court judges unanimously ruled last December that …
Stereoscopic Atlas of Macular Diseases: A Funduscopic and Angiographic Presentation
Authors: Albert M. Potts
Journal: JAMA (1971)

This is an excellent exposition of the state of the art in the diagnosis of retinal disease in general and macular disease in particular. The presentation by means of stereo color photos is a distinct asset, for the ability to see retinal boundaries, pigment epithelium (and lower layers in the presence of pathological defects) is an extra advantage not completely available even at the clinical examination. This is due to the exaggerated stereoscopic effect induced by camera disparity. The clinician is restricted to the disparity of his pupillary distance and even this is not fully realizable in the ordinary binocular ophthalmoscope. An ophthalmologist reading this atlas is impressed by the way thinking has progressed in the last decade, how powerful the tools are that have been brought to bear on the subject, and how far we have yet to go. As important as monocular clinical ophthalmoscopy has been, stereopsis with
Compulsory powers to see case-notes.
Authors: H G Jones
Journal: BMJ (1973)

miost famnily doctors do not understand what the Minister has in mind.If the G.P. is to provide contraceptive services, two problems are at once apparent.Firstly, in the average practice and particularly in young communities, there will be a staggering increase in the workload.Secondly, there is increasing criticism that family docEors have less time for their patients; family planning requires special skills and is unusually time-onsuming.The involve- ment of the G.P. in family planning under the N.H.S. may be a social and political ideal, but while the unwanted birth rate may fall, so may the time devoted to the care of the sick and those in need.The availability of "free" contraception is not in question.The ability of G.P.
Predictors of Laparoscopic Complications After Formal Training in Laparoscopic Surgery
Authors: William A. See
Journal: JAMA (1993)

To evaluate the relationship between laparoscopic complication rates and surgeon-dependent variables following a laparoscopic training course.Participants were surveyed regarding their interval laparoscopic experience 3 months and 12 months after the course.Course participants/survey respondents represented a cross section of urologic surgeons in the United States. A total of 181 individuals (61% of 297 participants) completed and returned the 3-month questionnaire. A total of 128 surgeons responded to the 12-month questionnaire (78.5% of 163 participants).Logistic regression analysis tested the relationship between surgeons' complication rates and study variables.At 3 months, surgeons who performed clinical procedures without additional training were 3.39 times more likely to have at least one complication compared with surgeons who sought additional training (P = .03). At 12 months, surgeons who had attended the training course alone, were in solo practice, or performed laparoscopic surgery with a variable assistant were 4.85, 7.74, and 4.80 times more likely, respectively, to have had a complication than their counterparts who attended the course with a partner, were in group practice, or operated with the same assistant (P = .004, P = .0008, and P = .0015, respectively). At both 3 and 12 months, laparoscopic complication rates of individual surgeons demonstrated a significant inverse correlation with the number of laparoscopic procedures performed.The rate of complications associated with the clinical learning curve can be decreased by additional education following an initial course in laparoscopy. An ongoing clinical association with surgeons performing similar procedures decreases long-term complication rates.
Message From Mahler
Authors: Dan Gehlbach
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A 10-Year Review of Otic Lichen Planus
Authors: Julio C. Sartori-Valinotti, Alison J. Bruce, Yulia Krotova Khan, Charles W. Beatty
Journal: JAMA Dermatology (2013)

<h3>Importance</h3> Lichen planus is an autoimmune inflammatory dermatosis that typically affects the skin but can also involve the stratified squamous epithelium of the external auditory canals and tympanic membranes. Here we report our experience with the clinical presentation, diagnosis, and management of otic lichen planus. <h3>Observations</h3> We retrospectively reviewed medical records from January 1, 2001, through May 31, 2011, of patients with a diagnosis of otic lichen planus. Nineteen cases were identified (mean age at diagnosis, 57 years; 15 women). The most common concerns were persistent otorrhea and hearing loss. Other symptoms included plugging, pruritus, tinnitus, pain, and bleeding. The mean symptom duration was 4.0 years (n = 13). Most patients responded well to topical tacrolimus within several months. One patient had a dramatic positive response to rituximab. <h3>Conclusions and Relevance</h3> Otic lichen planus can lead to persistent hearing loss and should be considered in the differential diagnosis of relentless otorrhea and external auditory canal stenosis. In our experience, topical tacrolimus is the best primary treatment, but alternative therapies could be instituted in severe cases. Early recognition of the nonspecific symptoms of otic lichen planus may lead to prompt treatment and avoidance of irreparable late sequelae.
Roche is fined for drug deal offer to health service
Authors: B. Burton
Journal: BMJ (2010)

An Australian subsidiary of the drug giant Roche has been fined $A200 000 (£124 200; €143 300; $199 500) for offering a regional public health organisation funding for a nursing position in exchange for doctors in the region prescribing its hepatitis drug peginterferon alfa-2a (marketed as Pegasys).

A health professional complained to the drug industry body Medicines Australia that Roche Products had breached the industry’s self regulatory code of conduct by offering the funding. Medicines Australia’s code committee found that the written offer “was contingent on the number of patients treated with Pegasys, with a sliding scale of increased funding for more patients treated.”

The code states that financial support from drug companies “must not be conditional …
Plasma catecholamines during exercise-induced bronchoconstriction in bronchial asthma.
Authors: J Zielinski, E Chodosowska, A Radomyski, Z Araszkiewicz, S Kozlowski
Journal: Thorax (1980)

Plasma levels of adrenaline and noradrenaline during and after submaximal exercise in patients with bronchial asthma were investigated. Three groups were studied comprising 10 patients with exercise-induced bronchoconstriction (EIB), 10 asthmatic patients without EIB and four normal control subjects. Plasma catecholamines were measured at rest, at the end of exercise, and five and 15 minutes after exercise. Changes in airway resistance were assessed by measuring peak expiratory flow rate. Significant differences in catecholamine levels between reacting and non-reacting patients were found. In 10 patients developing EIB adrenaline and noradrenaline levels had risen significantly by the end of exercise and remained elevated up to the fifth minute of recovery. The rise in catecholamine levels in non-reacting asthmatics was insignificant. In control subjects noradrenaline had increased significantly by the end of exercise.
Migratory Erythema and Glucagonoma: Descriptive Nomenclature
Authors: WALTER H. C. BURGDORF
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 June 1988Migratory Erythema and Glucagonoma: Descriptive NomenclatureWALTER H. C. BURGDORF, M.D.WALTER H. C. BURGDORF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-6-912_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I am puzzled by the report of Choksi and coworkers (1) on an unusual rash associated with a polypeptide-producing tumor of the pancreas. The authors state that the "skin lesions . . . appeared different from the migratory necrotizing erythema described with glucagonoma" and then that "skin biopsy showed focal spongiosis of the dermis . . . and no resemblance to the skin rash seen in glucagonoma."The patient's appearance is identical to that of many patients with necrolytic migratory erythema and glucagonoma who frequently have nasolabial and periorbital erythema. A widely available article describes an almost...References1. CHOKSI U, SELLIN R, and HICKEY R. An unusual skin rash associated with a pancreatic polypeptide-producing tumor of the pancreas. Ann Intern Med. 1988;108:64-5. LinkGoogle Scholar2. Case records of the Massachusetts General Hospital. N Engl J Med. 1985;292:1117-23. Google Scholar3. KHEIR S, OMURA E, and GRIZZLE W. Histologic variation in the skin lesions of glucagonoma syndrome. Am J Surg Pathol. 1986;10:445-53. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WALTER H. C. BURGDORF, M.D.Affiliations: University of New Mexico School of Medicine Albuquerque, NM 87131 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1988Volume 108, Issue 6Page: 912-913KeywordsBiopsyErythemaLesionsPancreasRashes ePublished: 1 December 2008 Issue Published: 1 June 1988 PDF downloadLoading ...
Discount war is predicted as NHS trusts are given right to compete on price
Authors: J. Laurance
Journal: BMJ (2010)

NHS trusts in England are to compete on price for the first time in what could become a supermarket style discount war as they strive to attract business in the new NHS market.

As part of the health secretary Andrew Lansley’s drive towards “liberating the NHS”—the subtitle of his white paper published in July ( BMJ 2010;341:c3796, doi:10.1136/bmj.c3796)—the rule requiring NHS trusts to operate with fixed prices, competing only on quality, is to be scrapped.

The change is contained in a single paragraph in the NHS Operating Framework for 2011-12, published on 16 December ( BMJ 2010;341:c7286, doi:10.1136/bmj.c7286). Critics have described it as “politically explosive,” with the potential to reduce quality, force hospital closures, and increase death rates.

Paragraph 5.43 on page 54 of the document says: “One new flexibility being introduced in 2011-12 is the opportunity for providers to offer …
Abstract 1148: The relationship between the EMT status in primary lung adenocarcinomas and the DFS, and the results of the molecular analyses of lung adenocarcinoma with regard to the IGF1R and EMT status
Authors: Yasuhiro Chikaishi, Hidetaka Uramoto, Masaru Takenaka, Soichi Oka, Makoto Nakagawa, Hidehiko Shimokawa, Tomoko So, Takeshi Hanagiri, Fumihiro Tanaka
Journal: Cancer Research (2012)

Abstract Background: Predicting the risk of distant micrometastasis of NSCLC after complete surgical resection is a significant problem to solve, and useful molecular markers that can predict recurrence have not yet been identified. The epithelial to mesenchymal transition (EMT) is an important contributor to the invasion and metastasis of epithelial-derived cancer. However, there is currently no data about the EMT status in primary NSCLC and its clinical usefulness to predict the recurrence and disease free survival (DFS). In addition, an association between insulin-like growth factor 1 (IGF1) and EMT-related molecules was reported, therefore, we also analyzed the association between the expression of IGF1R and EMT-related molecules. Methods: Tumor specimens were collected from 182 consecutive patients who underwent a complete resection for lung adenocarcinoma from 2003 to 2007 in our department. We analyzed the expression levels of EMT-related molecules (E-cadherin, gamma catenin and vimentin) in the primary lung adenocarcinoma by immunohistochemisty. We also analyzed the association between the expression of IGF1R and EMT-related molecules in the primary lung adenocarcinoma by immunohistochemisty. Results: The positive expression of E-cadherin, gamma catenin and vimentin was identified in 94 (51.4%), 82 (40.4%) and 32 (17.5%) patients, respectively. Their expression was not correlated with recurrence or disease-free survival (DFS) according to the survival analysis. Positive expression of IGF1R was detected in 43 (23.6%) patients, and its expression was significantly associated with the expression of E-cadherin and gamma-catenin, but not with vimentin.Conclusions: The EMT status in the primary tumor of NSCLC does not predict the recurrence and disease free survival. However, there was a significant association between the expression of IGF1R and several EMT-related proteins in patients with lung adenocarcinoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1148. doi:1538-7445.AM2012-1148
Effects of adjacent surfaces of different shapes on regurgitant jet sizes: An in vitro study using color Doppler imaging and laser-illuminated dye visualization
Authors: Jun Zhang, Takahiro Shiota, Robin Shandas, You-Bin Deng, Robert Weintraub, Juliana Paik, Dorian Liepmann, David J. Sahn
Journal: Journal of the American College of Cardiology (1993)
Prescriptions for the Traveler
Authors: Norman H. Eisenberg
Journal: JAMA (1975)

To the Editor.—  In our world of rapid transport, patients can find themselves in a foreign country where the loss of their baggage can mean the loss of their drug supply. Obtaining the correct drug may be made more complex by not only the biological availability variation of the foreign product but by its trade name, made evident by the following two examples.  First, the trade name Cardoxin is used in Israel for dipyridamole, the coronary dilater; the same name is used in Australia for digoxin. 1 Second, the trade name Didion, used in Europe to indicate the antiepileptic, ethadione, 2 is used in Israel for the indandione anticoagulant, diphenadione.  These two examples only emphasize the care that must be taken in writing that safety prescription for the traveler. The generic or chemical name must always be included with the trade name to prevent this type of inadvertent and potentially
ROLE OF FDG PET IN EVALUATION OF HEPATOCELLULAR CARCINOMA
Authors: Amol Takalkar, Peeyush Bhargava, Jian Q. Yu, Hongming Zhuang, Abass Alavi
Journal: Clinical Nuclear Medicine (2005)

Greater New York and New England Chapters, the Society of Nuclear Medicine 18th Annual Northeast Regional Scientific Session Abstracts October 22–October 24, 2004—Stamford, Connecticut: PDF Only
Debating Dual AIDS Guidelines
Authors: Rebecca Voelker
Journal: JAMA (1997)

PHYSICIANS SEEKING guidance on combination therapy for their HIVinfected patients may have felt a sense of déjà vu late last June. New guidelines from the US Department of Health and Human Services (DHHS) and the Henry J. Kaiser Family Foundation appeared for public comment June 19 in the<i>Federal Register</i>. Six days later, the American Medical Association (AMA) published an update of year-old recommendations from the International AIDS Society—USA (IAS-USA) (<i>JAMA</i>. 1997;277:1962-1969). Both recommend using a 3-drug combination that includes a protease inhibitor in the initial regimen. Both say that monotherapy constitutes substandard care. Both point out that if asymptomatic patients at low risk of disease progression can't comply with complex regimens, treatment probably should be delayed instead of risking the development of drug resistance. One of the few discrepancies surrounds the issue of when to start treatment. The IAS-USA update is more aggressive, recommending treatment when plasma HIV RNA