tbuckley/cabot-search huggingface dataset:
Perception of Atrial Fibrillation Before and After Radiofrequency Catheter Ablation
Authors: Gerhard Hindricks, Christopher Piorkowski, Hildegard Tanner, Richard Kobza, Jin-Hong Gerds-Li, Corrado Carbucicchio, Hans Kottkamp
Journal: Circulation (2005)

The objective of this study was to assess the incidence and impact of asymptomatic arrhythmia in patients with highly symptomatic atrial fibrillation (AF) who qualified for radiofrequency (RF) catheter ablation.In this prospective study, 114 patients with at least 3 documented AF episodes together with corresponding symptoms and an ineffective trial of at least 1 antiarrhythmic drug were selected for RF ablation. With the use of CARTO, circumferential lesions around the pulmonary veins and linear lesions at the roof of the left atrium and along the left atrial isthmus were placed. A continuous, 7-day, Holter session was recorded before ablation, right after ablation, and after 3, 6, and 12 months of follow-up. During each 7-day Holter monitoring, the patients recorded quality and duration of any complaints by using a detailed symptom log. More than 70,000 hours of ECG recording were analyzed. In the 7-day Holter records before ablation, 92 of 114 patients (81%) had documented AF episodes. All episodes were symptomatic in 35 patients (38%). In 52 patients (57%), both symptomatic and asymptomatic episodes were recorded, whereas in 5 patients (5%), all documented AF episodes were asymptomatic. After ablation, the percentage of patients with only asymptomatic AF recurrences increased to 37% (P<0.05) at the 6-month follow-up. An analysis of patient characteristics and arrhythmia patterns failed to identify a specific subset who were at high risk for the development of asymptomatic AF.Even in patients presenting with highly symptomatic AF, asymptomatic episodes may occur and significantly increase after catheter ablation. A symptom-only-based follow-up would substantially overestimate the success rate. Objective measures such as long-term Holter monitoring are needed to identify asymptomatic AF recurrences after ablation.
Editorial: Immunity against contagious diseases: inadequacies
Authors: H. H. Hussey
Journal: JAMA (1974)

Rubella is a mild viral disease occurring usually in early childhood. It would be disregarded except for the fact that when the disease occurs in a pregnant woman, strong likelihood exists that the fetus will suffer serious adverse effects. This fact accounts for the extensive efforts to administer rubella vaccine to all children to ensure that they will not acquire and transmit the disease to nonimmune pregnant mothers. Schiff et al<sup>1</sup>, reported the extent of rubella susceptibility among high school students in a remote resort town in north central Wisconsin. Blood was collected from the students during school hours and later tested for rubella immunity at the Clinical Virology Laboratories in Cincinnati. With parental permission, 127 boys and 215 girls participated, only ten of whom had received rubella immunization. Although 37% of the students gave a history of previous rubella, there was no correlation between the history and susceptibility
Patients' and Families' Preferences for Medical Intensive Care
Authors: Marion Danis
Journal: JAMA (1989)

<h3>To the Editor.—</h3> We are responding to several editorial comments by Dr Zweibel<sup>1</sup>about our study of patients' and families' preferences for medical intensive care.<sup>2</sup>First, she states that the question that the research addresses was to what extent quality-of-life judgments should be applied in decision making for incompetent patients when no advance directive exists. In fact, we set out to determine to what extent quality of life predicts patients' treatment preferences. We found that quality of life was a poor predictor of patient preference for intensive care. We do not conclude from this, however, that quality of life is irrelevant to the treatment decision, but rather that it is not a simple matter to extrapolate from quality of life to treatment preferences. Second, Dr Zweibel is concerned about the method used to measure quality of life. It is important to note that the Perceived Quality of Life
Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D
Authors: Marie Meeths, Samuel C. C. Chiang, Stephanie M. Wood, Miriam Entesarian, Heinrich Schlums, Benedicte Bang, Edvard Nordenskjöld, Caroline Björklund, Gordana Jakovljevic, Janez Jazbec, Henrik Hasle, Britt-Marie Holmqvist, Ljubica Rajić, Susan Pfeifer, Steen Rosthøj, Magnus Sabel, Toivo T. Salmi, Tore Stokland, Jacek Winiarski, Hans-Gustaf Ljunggren, Bengt Fadeel, Magnus Nordenskjöld, Jan-Inge Henter, Yenan T. Bryceson
Journal: Blood (2011)
AN ANOMALOUS SUPERFICIAL DERMATITIS OCCURRING DURING TYPHOID FEVER, AND HAVING SOME RESEMBLANCE TO PSORIASIS RUPIOIDES
Authors: H. D. ROLLESTON, J. W. MERCER
Journal: British Journal of Dermatology (1902)

Journal Article AN ANOMALOUS SUPERFICIAL DERMATITIS OCCURRING DURING TYPHOID FEVER, AND HAVING SOME RESEMBLANCE TO PSORIASIS RUPIOIDES Get access H. D. ROLLESTON, M.D., F.R.C.P., H. D. ROLLESTON, M.D., F.R.C.P. Physician to St. George's Hospital Search for other works by this author on: Oxford Academic Google Scholar J. W. B.A. CANTAB MERCER J. W. B.A. CANTAB MERCER Physician to St. George's Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 14, Issue 6, 1 June 1902, Pages 213–215, https://doi.org/10.1111/j.1365-2133.1902.tb16451.x Published: 01 June 1902
Randomised controlled trial exists of levonorgestrel intrauterine system for menorrhagia
Authors: A. Ikomi, N. Gupta
Journal: BMJ (1998)

EDITOR— We agree with Prentice's comments that the study by Lahteenmaki et al does not allow the conclusion that the levonorgestrel intrauterine system is an alternative to transcervical resection of endometrium.1 However, we were surprised that neither the study …
Inflammatory Bowel Disease: A Guide For Patients And Their Families.
Authors: J F MAYBERRY
Journal: Gut (1999)

Inflammatory Bowel Disease: A Guide For Patients And Their Families. 2nd edition. Edited by Stein SH, Rood RP. (Pp 256; illustrated; $22.00/£13.75, Int. $25.00/£15.63.) Lippincott Williams and Wilkins, 1998. ISBN 0-397-51771-8.

This is without question an excellent book. It attempts with considerable success to provide a “textbook” for the patient with inflammatory bowel disease (IBD). As with most textbooks, it is not an easy read but sets out to give an exhaustive account of the cause, symptoms, investigation, and management of patients with ulcerative colitis and Crohn’s disease. As a result it does …
p53 immunoreactivity in human malignant melanoma and dysplastic naevi
Authors: J.M. MCGREGOR, C.C-W. YU, E.A. DUBLIN, D.M. BARNES, D.A. LEVISON, D.M. MACDONALD
Journal: British Journal of Dermatology (1993)

Expression of the tumour suppressor protein, p53, was determined in 77 cutaneous melanocytic lesions, and in five lymph node metastases from malignant melanoma, in an immunohistochemical study employing CM-1, an antiserum raised against recombinant human p53 protein. Because wild-type p53 protein is rapidly degraded in normal cells, p53 immunoreactivity suggests the presence of an abnormally stable p53 protein. This may occur through either post-translational mechanisms or gene mutation. A highly significant correlation was found between p53 immunoreactivity and malignancy in melanocytic lesions (P < 0.0001). Overall, p53 immunoreactivity was observed in 63% of tumour specimens examined, but not in benign melanocytic naevi, although occasional foci of weak nuclear p53 immunoreactivity were observed in a minority of dysplastic naevi and a solitary Spitz naevus. A significant correlation was also found between strong p53 immunoreactivity and malignant melanomas associated with a poor prognosis (P = 0.008). These data suggest an important role for p53 tumour suppressor protein in the biology of human cutaneous malignant melanoma.
Effects of procainamide on the signal-averaged electrocardiogram in relation to the results of programmed ventricular stimulation in patients with sustained monomorphic ventricular tachycardia
Authors: Piotr Kulakowski, Yaver Bashir, Spencer Heald, Vince Paul, Mark H. Anderson, Sheila Gibson, Marek Malik, A.John Camm
Journal: Journal of the American College of Cardiology (1993)
Bevacizumab-based therapy for advanced small bowel adenocarcinoma
Authors: H Tsang, T Yau, P L Khong, R J Epstein
Journal: Gut (2008)

We were most interested to read the recent report by Serviddio and colleagues ( Gut 2008; 57 :957–65). This work not only showed that upregulation of uncoupling protein-2 was a reason for progression of non-alcoholic steatohepatitis (NASH) from simple steatosis, but also gave an explanation for why NASH liver was especially vulnerable to ischaemia–reperfusion injury.

NASH is a common liver disease that is estimated to affect nearly 1% of the population. A growing body of evidences shows that NASH …
Sengstaken Balloon Tamponade for Life-Threatening Pouch Hemorrhage after Laparoscopic Gastric Banding
Authors: H. Nehoda, H. Weiss, B. Labeck, M. Lanthaler, K. Hourmount, M. Oberwalder, F. Aigner
Journal: Endoscopy (2001)

Laparoscopic gastric banding is advocated as a minimally invasive procedure with a low risk profile and high efficacy in the treatment of morbid obesity.
Quantitative Coronary Angiographic Studies of Patients With Angina Pectoris and Impaired Glucose Tolerance
Authors: Yu Kataoka, Satoshi Yasuda, Isao Morii, Yoritaka Otsuka, Atsushi Kawamura, Shunichi Miyazaki
Journal: Diabetes Care (2005)

We investigated the morphological characteristics of coronary arteries in patients with impaired glucose tolerance (IGT) using computer-assisted quantitative coronary angiography. IGT is an independent risk factor for cardiovascular disease. However, the morphological changes developing in the coronary arteries of patients with IGT remain unknown.A total of 534 patients with angina pectoris were studied. Of these, 144 patients were being treated for diabetes. The remaining 390 patients were classified as follows depending on the results of a 75-g oral glucose tolerance test: normal glucose tolerance (NGT) (n = 117), impaired fasting glucose (n = 3), IGT (n = 136), and diabetes pattern (preclinical diabetes) (n = 134). The diameters of the middle section of all major coronary artery segments were measured and averaged to determine the averaged vessel diameter (AVD). We defined segments of a diameter of < or = 1.5 mm as diseased lesions and determined the averaged lesion length (ALL).AVD and ALL were significantly different among patients with IGT and those with NGT. Patients with diabetes (preclinical and/or treated) had smaller AVD and longer ALL than those with IGT. By multivariate analysis, postprandial glucose levels were shown to be independently associated with an AVD <3.0 mm and an ALL >20 mm.Diffuse coronary artery narrowing develops not only in patients with diabetes but also in those with IGT. This morphological change is associated with postprandial hyperglycemia.
Failure of Penicillin in a Newborn With Congenital Syphilis
Authors: Janet B. Hardy
Journal: JAMA (1970)

<i>A newborn had congenital syphilis, which was characterized by wide-spread infection of meninges, liver, pancreas, peritoneum, and long bones. In spite of treatment given to the mother ten days prior to delivery, and massive doses of penicillin G potassium given to the infant for 17 days after birth, viable and virulent</i>Treponema pallidum<i>were recovered from both the aqueous fluid and ground eye tissue removed at the autopsy, which was performed when the child died at age 22 days.</i>
Relationship of Leisure-Time Physical Activity and Mortality
Authors: Urho M. Kujala, Jaakko Kaprio, Seppo Sarna, Markku Koskenvuo
Journal: JAMA (1998)

Physical activity and fitness are believed to reduce premature mortality, but whether genetic factors modify this effect is not known.To investigate leisure physical activity and mortality with respect to familial aggregation of health habits during childhood and factors that may enable some individuals to achieve higher levels of fitness.Prospective twin cohort study.Finland.In 1975, at baseline, 7925 healthy men and 7977 healthy women of the Finnish Twin Cohort aged 25 to 64 years who responded to a questionnaire on physical activity habits and known predictors of mortality. Those who reported exercising at least 6 times per month with an intensity corresponding to at least vigorous walking for a mean duration of 30 minutes were classified as conditioning exercisers, those who reported no leisure physical activity were classified as sedentary, and other subjects were classified as occasional exercisers.All-cause mortality and discordant deaths among same-sex twin pairs from 1977 through 1994.Among the entire cohort, 1253 subjects died. The hazard ratio for death adjusted for age and sex was 0.71 (95% confidence interval [CI], 0.62-0.81) in occasional exercisers and 0.57 (95% CI, 0.45-0.74) in conditioning exercisers, compared with those who were sedentary (Pfor trend <.001). Among the twin pairs who were healthy at baseline and discordant for death (n=434), the odds ratio for death was 0.66 (95% CI, 0.46-0.94) in occasional exercisers and 0.44 (95% CI, 0.23-0.83) in conditioning exercisers compared with those who were sedentary (P for trend, .005). The beneficial effect of physical activity remained after controlling for other predictors of mortality.Leisure-time physical activity is associated with reduced mortality, even after genetic and other familial factors are taken into account.
Doctors claim to have cured girl of HIV
Authors: B. Roehr
Journal: BMJ (2013)

Doctors claim to have cured a child of HIV through the very early administration of antiretrovirals. 

The initial treatment was carried out at the University of Mississippi, and the follow-up search to detect the virus was done at Johns Hopkins University, Baltimore. The case was presented at the 20th annual Conference on Retroviruses and Opportunistic Infections in Atlanta this week.

The girl was born somewhat prematurely to a mother who did not know that she was infected with the virus and who had a high viral load. The girl was born with HIV. The virus can be transmitted from mother to child in utero or at delivery, and the likelihood of transmission increases with the viral load.

A blood test of the …
894 FEMALE SEX AND VARIATIONS IN IL28B ARE INDEPENDENTLY ASSOCIATED WITH SPONTANEOUS CLEARANCE OF ACUTE HCV INFECTION
Authors: J. Grebely, G.J. Dore, M. Schim van der Loeff, T. Rice, A.L. Cox, J. Bruneau, A.Y. Kim, J. George, L. Maher, A.R. Lloyd, M. Hellard, K. Page, M. Prins
Journal: Journal of Hepatology (2012)
Hematologic Response to Three Alternative Dosing Schedules of Azacitidine in Patients With Myelodysplastic Syndromes
Authors: Roger M. Lyons, Thomas M. Cosgriff, Sanjiv S. Modi, Robert H. Gersh, John D. Hainsworth, Allen L. Cohn, Heidi J. McIntyre, Indra J. Fernando, Jay T. Backstrom, C.L. Beach
Journal: Journal of Clinical Oncology (2009)

Azacitidine (AZA) is effective treatment for myelodysplastic syndromes (MDS) at a dosing schedule of 75 mg/m(2)/d subcutaneously for 7 days every 4 weeks. The initial phase of this ongoing multicenter, community-based, open-label study evaluated three alternative AZA dosing schedules without weekend dosing.MDS patients were randomly assigned to one of three regimens every 4 weeks for six cycles: AZA 5-2-2 (75 mg/m(2)/d subcutaneously for 5 days, followed by 2 days no treatment, then 75 mg/m(2)/d for 2 days); AZA 5-2-5 (50 mg/m(2)/d subcutaneously for 5 days, followed by 2 days no treatment, then 50 mg/m(2)/d for 5 days); or AZA 5 (75 mg/m(2)/d subcutaneously for 5 days).Of patients randomly assigned to AZA 5-2-2 (n = 50), AZA 5-2-5 (n = 51), or AZA 5 (n = 50), most were French-American-British (FAB) lower risk (refractory anemia [RA]/RA with ringed sideroblasts/chronic myelomonocytic leukemia with < 5% bone marrow blasts, 63%) or RA with excess blasts (30%), and 79 (52%) completed > or = six treatment cycles. Hematologic improvement (HI) was achieved by 44% (22 of 50), 45% (23 of 51), and 56% (28 of 50) of AZA 5-2-2, AZA 5-2-5, and AZA 5 arms, respectively. Proportions of RBC transfusion-dependent patients who achieved transfusion independence were 50% (12 of 24), 55% (12 of 22), and 64% (16 of 25), and of FAB lower-risk transfusion-dependent patients were 53% (nine of 17), 50% (six of 12), and 61% (11 of 18), respectively. In the AZA 5-2-2, AZA 5-2-5, and AZA 5 groups, 84%, 77%, and 58%, respectively, experienced > or = 1 grade 3 to 4 adverse events.All three alternative dosing regimens produced HI, RBC transfusion independence, and safety responses consistent with the currently approved AZA regimen. These results support AZA benefits in transfusion-dependent lower-risk MDS patients.
Reforming the HIPAA Privacy Rule
Authors: Lawrence O. Gostin, Sharyl Nass
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Development and validation of a technique for continuous monitoring of gastric intramucosal pH.
Authors: J A Guzman, J A Kruse
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

A novel method for continuously monitoring gastric intramucosal PCO2 and pH was developed and tested. Gas was continuously circulated through a modified balloon-tipped catheter connected to an external closed system fitted with an infrared CO2 sensor to monitor PCO2. Performance of the capnometric recirculating gas tonometry (CRGT) system was tested in vitro using an equilibration chamber and in vivo in six anesthetized dogs. Serial PCO2 measurements were made using CRGT and compared with intermittent PCO2 values obtained by conventional tonometry catheters. In the animal experiments, gastric intramucosal PCO2 and pH were determined before and after inducing hypoxia by decreasing the Flo2 to 0.08. After initial placement, PCO2 determined by the CRGT reached a near plateau within 45 min, and at that time point values were comparable to those obtained by conventional intermittent tonometry. Significant increases in gastric intramucosal PCO2 were detectable by CRGT within 5 min of inducing systemic hypoxia, and there was a concomitant significant decrease in intramucosal pH. Continuous monitoring of gastric intramucosal PCO2 and pH is feasible, has potential advantages over conventional methods, and can provide significant trending information over intervals as short as 5 min.
Histocompatibility antigens and genetic control of the immune response in guinea pigs. III. Specific inhibition of antigen-induced lymphocyte proliferation by strain-specific anti-idiotypic antibodies.
Authors: A F Geczy, C L Geczy, A L de Weck
Journal: The Journal of Experimental Medicine (1976)

The in vitro T-cell proliferation induced by penicilloylated bovine IgG (BPO-BGG) in sensitized strain 2 and strain 13 guinea pigs could be specifically blocked by strain-specific antisera presumably directed against cell membrane-associated immunoglobulin idiotypes. The anti-idiotypic antisera were prepared in strain 2 and strain 13 guinea pigs against immunoadsorbent purified anti-BPO-BGG antibodies which had been raised in strain 2 and strain 13 animals. Strain 13 antistrain 13 anti-BPO-BGG (a strain 13 BPO-BGG) suppressed the in vitro BPO-BGG response of cells from immunized strain 13 animals but did not inhibit the response of cells from immune strain 2 animals. Conversely, the corresponding antiserum raised in a strain 2 combination (a strain 2 BPO-BGG) only inhibited the in vitro BPO-BGG response of strain 2 cells. Furthermore, the inhibitory activity of the antisera could only be absorbed by immune cells from the syngeneic strain. The activity of the a strain 13 BPO-BGG serum was highly specific; the inhibitory activity could only be absorbed by BPO-BGG-sensitive strain 13 cells. The inhibitory activity of the anti-idiotypic sera was predominantly associated with the 19S fraction. The data suggest that immune cells and in particular T lymphocytes from strain 2 and strain 13 guinea pigs possess strain-specific recognition structures from BPO-BGG with the same idiotypes as the corresponding strain-specific immunoglobulins. Furthermore, the production of such inhibitory anti-idiotypic sera was restricted to syngeneic combinations, which suggests a potential role of autoanti-idiotypic antibodies in the regulation of the immune response. The anti-idiotypic antisera used here are apparently directed against gene products not associated with the strain 2 or strain 13 major histocompatibility complex.
Coronary bypass surgery. Value of maximal exercise testing in assessment of results
Authors: AJ Merrill, C Thomas, E Schechter, R Cline, R Armstrong, W Stanford
Journal: Circulation (1975)

To evaluate the relationship of results of maximal treadmill testing and results of saphenous vein bypass surgery (SVG), 30 patients underwent a maximal treadmill test before and after SVG; an additional 39 had results of postoperative exercise testing available. These patients were part of a group of 91 patients (95% of 96 survivors) who had complete right- and left-heart catheterizations and coronary angiography before and after operation. Twenty-one per cent had improved ejection fractions postoperatively; in 32% ejection fractions were worse. Duration of maximal treadmill exercise correlated poorly with ejection fraction changes or graft patency. Rate-pressure product (RPP) was usually lower postoperatively in patients with worse ejection fractions, primarily because of a low systolic blood pressure at maximum exercise. RPP postoperatively of less than 25,000 almost always meant poor surgical results, either graft occlusion or poor left ventricular function, while RPP of more than 30,000 meant that left ventricular function was preserved and all grafts or the graft to the anterior descending were patent. Thus, success or failure of SVG in these groups may be predicted without postoperative catheterization. An open graft to the anterior descending coronary generally insured a high RPP with exercise, even if other grafts were closed, as long as ventricular function remained good.
Time to Operate
Authors: Daniel M. Taylor
Journal: JAMA (1964)

<h3>To the Editor:—</h3> A letter by Dr. Gunter von Noorden of Baltimore appeared in the May 4, 1964, issue ofThe Journal(<b>188:</b>472) criticizing a paper of mine entitled "How Early Is Early Surgery in the Management of Strabismus?" which was published in the December, 1963, issue of the<i>Archives of Ophthalmology</i>(<b>70:</b>752) and which was discussed in aJournaleditorial (<b>187:</b>298 [Jan 25] 1964). I disagree with von Noorden's views as does Dr. Costenbader, who feels that his work has been misinterpreted.