Hypoadrenocorticotropism with Hyponatremia, Resembling Antidiuretic Hormone Excess
Authors: JOSEPH L. GRANT
Journal: Annals of Internal Medicine (1965)

Case Studies1 September 1965Hypoadrenocorticotropism with Hyponatremia, Resembling Antidiuretic Hormone ExcessJOSEPH L. GRANT, M.D., F.A.C.P., ALASTAIR MACDONALD, STEPHEN R. BROVENDER, M.D., NICHOLAS YANKOPOULOS, M.D.JOSEPH L. GRANT, M.D., F.A.C.P.Search for more papers by this author, ALASTAIR MACDONALDSearch for more papers by this author, STEPHEN R. BROVENDER, M.D.Search for more papers by this author, NICHOLAS YANKOPOULOS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-3-486 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBoth the anterior and posterior lobes of the pituitary gland affect water handling, independently of sodium. The anterior pituitary stimulates the adrenal cortex to elaborate glucocorticoid, which promotes diuresis of water loads. The posterior pituitary secretes antidiuretic hormone (ADH) that causes water retention. Recent reports (1-6) have shown that certain patients have inappropriate levels of ADH with consequent water intoxication, and it is a well-established clinical fact that diabetes insipidus never fully develops in patients with adrenal cortical insufficiency. The patient reported here brings into focus the similarity of ADH excess and glucocorticoid deficiency, and the importance of the differential...References1. SCHWARTZBENNETTCURELOPBARTTER WBWSFC: Syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antiduretic hormone. Amer. J. Med. 23: 529, 1957. CrossrefMedlineGoogle Scholar2. ROBERTS HJ: Syndrome of hyponatremia and renal sodium loss probably resulting from inappropriate secretion of antidiuretic hormone. Ann. Intern. Med. 51: 1420, 1959. LinkGoogle Scholar3. 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BETHUNENELSON JEDH: Hyponatremia in hypopituitarism. New Eng. J. Med. 272: 171, 1965. CrossrefGoogle Scholar23. DINGMANDESPOINTES JFRH: Adrenal steroid inhibition of vasopressin release from the neurohypophysis of normal subjects and patients with Addison's disease. J. Clin. Invest. 39: 1851, 1960. CrossrefMedlineGoogle Scholar24. GOODMANGILMAN LSA: The Pharmacological Basis of Therapeutics, 2nd ed., the Macmillan Co., New York, 1958, p. 621. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOSEPH L. GRANT, M.D., F.A.C.P.; ALASTAIR MACDONALD; STEPHEN R. BROVENDER, M.D.; NICHOLAS YANKOPOULOS, M.D.Affiliations: From the Medical and Research Services, Veterans Administration Hospital, White River Junction, Vt., and Dartmouth Medical School, Hanover, N. H.Requests for reprints should be addressed to Joseph L. Grant, M.D., Chief, Medical Service, Veterans Administration Hospital, White River Junction, Vt. 05001. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byParaneoplasien der Neoplasmen der Bronchien und der LungeCase Report Isolated ACTH Deficiency Presenting as Severe HypercalcemiaEktope paraneoplastische Endokrinopathien mit St�rungen des Wasser- und ElektrolythaushaltesThe Mechanism of Hyponatremia in Pulmonary TuberculosisROBERT J. SHALHOUB, M.D., F.A.C.P., LUCY D. ANTONIOU, M.D.The Role of Adrenocorticoids in the Inappropriate Antidiuretic Hormone SyndromeMARSHAL P. FICHMAN, M.D., JOHN E. BETHUNE, M.D., F.A.C.P. 1 September 1965Volume 63, Issue 3Page: 486-494KeywordsAdrenal cortexAntidiuretic hormoneHealth services researchHyponatremiaIntoxicationLesionsPituitary glandRiversSodium ePublished: 1 December 2008 Issue Published: 1 September 1965 PDF downloadLoading ...