tbuckley/cabot-search huggingface dataset:
Basic Mechanisms: Selective Perception and Alienation
Authors: George G. Reader
Journal: JAMA (1964)

IN ONE OF the discussion groups at the Association of American Medical Colleges (AAMC) 1962 Institute on "The Medical School and the Practicing Profession" a university surgeon complained bitterly about welfare patients being transferred from care at his hospital to a prepaid group practice program. He pointed out that such patients were essential to the teaching of surgery. When asked if his hospital was prepared to render as complete care as the prepaid group, he became indignant. His institution is world-renowned; society not only owes him the patients needed for teaching but also should so organize the care of these patients that the hospital takes responsibility only for their important lesions. There should be enough patients requiring a gastric resection each week to keep the surgical residents busy, but not more than that. When these same patients come back with varicose veins or hemorrhoids, he would have them referred to
Baroreflex sensitivity measured by the phenylephrine pressor test in patients with carotid sinus and sick sinus syndromes
Authors: C A MORLEY, T C B DEHN, E J PERRINS, S L CHAN, R SUTTON
Journal: Cardiovascular Research (1984)

Journal Article Baroreflex sensitivity measured by the phenylephrine pressor test in patients with carotid sinus and sick sinus syndromes Get access C A MORLEY, C A MORLEY * From the Department of Cardiology, Westminster Hospital, Horseferry Road, London SWl *Correspondence and reprint requests to: Dr C A Morley, present appointment, Lecturer in Cardiology, University of Leeds, Yorkshire. Search for other works by this author on: Oxford Academic PubMed Google Scholar T C B DEHN, T C B DEHN From the Department of Cardiology, Westminster Hospital, Horseferry Road, London SWl Search for other works by this author on: Oxford Academic PubMed Google Scholar E J PERRINS, E J PERRINS From the Department of Cardiology, Westminster Hospital, Horseferry Road, London SWl Search for other works by this author on: Oxford Academic PubMed Google Scholar S L CHAN, S L CHAN From the Department of Cardiology, Westminster Hospital, Horseferry Road, London SWl Search for other works by this author on: Oxford Academic PubMed Google Scholar R SUTTON R SUTTON From the Department of Cardiology, Westminster Hospital, Horseferry Road, London SWl Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 18, Issue 12, December 1984, Pages 752–761, https://doi.org/10.1093/cvr/18.12.752 Published: 01 December 1984
(50) Dermatomyositis, systemic sclerosis and polyneuropathy
Authors: N.R. Rowell
Journal: British Journal of Dermatology (1987)

Journal Article (50) Dermatomyositis, systemic sclerosis and polyneuropathy Get access N.R. Rowell N.R. Rowell The General Infirmary at Leeds. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue s32, 1 June 1987, Pages 103–104, https://doi.org/10.1111/j.1365-2133.1987.tb12090.x Published: 01 June 1987
Protection of children against sunburn: a survey of parental practice in Leicester
Authors: J. F. BOURKE, R. A. C. GRAHAM-BROWN
Journal: British Journal of Dermatology (1995)

Journal Article Protection of children against sunburn: a survey of parental practice in Leicester Get access J. F. BOURKE, J. F. BOURKE Department of Dermatology, leicester Royal Infirmary, Leicester LE I 5WW, U.K. Search for other works by this author on: Oxford Academic Google Scholar R. A. C. GRAHAM‐BROWN R. A. C. GRAHAM‐BROWN Department of Dermatology, leicester Royal Infirmary, Leicester LE I 5WW, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 133, Issue 2, 1 August 1995, Pages 264–266, https://doi.org/10.1111/j.1365-2133.1995.tb02626.x Published: 01 August 1995 Article history Accepted: 18 October 1994 Published: 01 August 1995
EXAGGERATED EXERCISE BLOOD PRESSURE RESPONSE IS ACCOMPANIED BY A STATE OF ARTERIAL STIFFENING, AUGMENTED ASYMMETRIC DIMETHYLARGININE AND OSTEOPROTEGERIN LEVELS IN ESSENTIAL HYPERTENSIVE SUBJECTS
Authors: K. Dimitriadis, K. Tsioufis, D. Tsiachris, L. Lioni, I. Andrikou, A. Kordalis, G. Chlapoutakis, D. Flessas, C. Stefanadis
Journal: Journal of the American College of Cardiology (2011)
Duplication of 10 nucleotides in the erythroid band 3 (AE1) gene in a kindred with hereditary spherocytosis and band 3 protein deficiency (band 3PRAGUE).
Authors: P Jarolim, H L Rubin, S C Liu, M R Cho, V Brabec, L H Derick, S J Yi, S T Saad, S Alper, C Brugnara
Journal: Journal of Clinical Investigation (1994)

We describe a duplication of 10 nucleotides (2,455-2,464) in the band 3 gene in a kindred with autosomal dominant hereditary spherocytosis and a partial deficiency of the band 3 protein that is reflected by decreased rate of transmembrane sulfate flux and decreased density of intramembrane particles. The mutant allele potentially encodes an abnormal band 3 protein with a 3.5-kD COOH-terminal truncation; however, we did not detect the mutant protein in the membrane of mature red blood cells. Since the mRNA levels for the mutant and normal alleles are similar and since the band 3 content is the same in the light and dense red cell fractions, we conclude that the mutant band 3 is either not inserted into the plasma membrane or lost from the membrane prior to the release of red blood cells into circulation. We further show that the decrease in band 3 content principally involves the dimeric laterally and rotationally mobile fraction of the band 3 protein, while the laterally immobile and rotationally restricted band 3 fraction is left essentially intact. We propose that the decreased density of intramembrane particles decreases the stability of the membrane lipid bilayer and causes release of lipid microvesicles that leads to surface area deficiency and spherocytosis.
Recurrent spleen enlargement during cyclic granulocyte‐macrophage colony‐stimulating factor therapy for myelodysplastic syndrome
Authors: A. Delmer, M. Karmochkine, M. Cadiou, H. Gerhartz, R. Zittoun
Journal: American Journal of Hematology (1990)

Abstract A 65‐year‐old woman with refractory anemia with excess of blasts received sequential courses of granulocyte‐macrophage colony‐stimulating factor therapy (GM‐CSF) and low‐dose cytosine arabinoside. Each course of GM‐CSF induced a rapid and tremendous increase in leukocyte count as well as in spleen size, 111 indium chloride scanning suggested a myeloid metaplasia of the spleen. This observation suggests that in some patients the granulopoietic response to the myeloid growth factor stimulation may be predominant in the spleen.
A Novel Channelopathy in Pulmonary Arterial Hypertension
Authors: Lijiang Ma, Danilo Roman-Campos, Eric D. Austin, Mélanie Eyries, Kevin S. Sampson, Florent Soubrier, Marine Germain, David-Alexandre Trégouët, Alain Borczuk, Erika Berman Rosenzweig, Barbara Girerd, David Montani, Marc Humbert, James E. Loyd, Robert S. Kass, Wendy K. Chung
Journal: New England Journal of Medicine (2013)

Pulmonary arterial hypertension is a devastating disease with high mortality. Familial cases of pulmonary arterial hypertension are usually characterized by autosomal dominant transmission with reduced penetrance, and some familial cases have unknown genetic causes.We studied a family in which multiple members had pulmonary arterial hypertension without identifiable mutations in any of the genes known to be associated with the disease, including BMPR2, ALK1, ENG, SMAD9, and CAV1. Three family members were studied with whole-exome sequencing. Additional patients with familial or idiopathic pulmonary arterial hypertension were screened for the mutations in the gene that was identified on whole-exome sequencing. All variants were expressed in COS-7 cells, and channel function was studied by means of patch-clamp analysis.We identified a novel heterozygous missense variant c.608 G→A (G203D) in KCNK3 (the gene encoding potassium channel subfamily K, member 3) as a disease-causing candidate gene in the family. Five additional heterozygous missense variants in KCNK3 were independently identified in 92 unrelated patients with familial pulmonary arterial hypertension and 230 patients with idiopathic pulmonary arterial hypertension. We used in silico bioinformatic tools to predict that all six novel variants would be damaging. Electrophysiological studies of the channel indicated that all these missense mutations resulted in loss of function, and the reduction in the potassium-channel current was remedied by the application of the phospholipase inhibitor ONO-RS-082.Our study identified the association of a novel gene, KCNK3, with familial and idiopathic pulmonary arterial hypertension. Mutations in this gene produced reduced potassium-channel current, which was successfully remedied by pharmacologic manipulation. (Funded by the National Institutes of Health.)
THORACIC ENDOVASCULAR AORTIC REPAIR VERSUS MEDICAL TREATMENT FOR TYPE B AORTIC DISSECTIONS. A COMPARATIVE RETROSPECTIVE VOLUMETRIC ANALYSIS
Authors: MINH HOANG TRAN, Kim-Diep DANG-TRAN, Omar El Aassar, Ramiro Moreno, Adil Baali, Benjamin HONTON, Julien Auriol, Bertrand Marcheix, Hervé Rousseau
Journal: Journal of the American College of Cardiology (2010)
Transvestitism and Trans-sexualism
Authors: J. B. Randell
Journal: BMJ (1959)

Transvestitism is the impulse to wear the clothing of the opposite sex, and was given this name by Hirschfeld (1910).Ellis (1936) described the condition as a state of psychosexual inversion and called it eonism, after the Chevalier d'Eon, a French diplomat at the Court of St. James, who lived as a woman for much of his life.Trans-sexualism is the term used by Benjamin (1954) to describe the wish to change the anatomical sex.The nature of the condition suggests that transvestite and trans-sexualist individuals are predominantly homo- sexual in orientation and behaviour, and the following report on 50 such patients offers an opportunity to examine this possibility and the aetiological factors involved in the production of such deviate behaviour.Norwood East (1949) stated that the desire to wear the clothes of the opposite sex was widespread.He did not indicate the frequency of its occurrence, but believed it to be more common than is realized.Transvestites proper were defined as those men who obtained sexual gratification from dressing as, and pretending to be, women; he found that in appearance, manner, and interest they appeared to be more feminine than masculine, but also remarked that some male homosexual prostitutes wear the clothes of the female sex to vary or enhance their attractiveness to men.The practice of cross-dressing is also found as a cultural variant in primitive societies; for example, Seward (1954) describes it as occurring among the Mohave Indians of North America, and also in the latmul people of New Guinea.Krafft-Ebing (1916) cites a report of similar behaviour found by Holder in the Montana Indians.The term transvestitism is not intended to include the wearing of the clothes of the opposite sex for theatrical purposes, burlesque, or disguise.In transvestitism the clothes or the wearing of them may provide an end in itself; they are usually endowed with sexual significance, and the act of wearing them may provide the sole form of sexual expression or outlet.The condition occurs in both sexes, though male patients come to notice more often as current fashions in female clothing permit transvestite women to wear garments which have male characteristics without undue attention being drawn to the transvestite act.Wearing the garments of the opposite sex is forbidden for both sexes by Mosaic Law (Deuteronomy xxii.5).Clinical Material.-Thepatients in the present survey comprise 37 males and 13 females.Many of these patients were referred from the endocrine clinic at Charing Cross Hospital, and were seeking operations "to change their sex " or advice on their problems.
Thymidine Phosphorylase and Dihydropyrimidine Dehydrogenase in Renal Cell Carcinoma: Relationship between Histological Parameters and Chemosensitivity to 5-Fluorouracil
Authors: Yasuhiro Hirano, Tatsuya Takayama, Shinji Kageyama, Tomomi Ushiyama, Kazuo Suzuki, Kimio Fujita
Journal: European Urology (2002)
Abstract 2198: A functional ETS/E2F module in cancers expressing ETS fusion genes
Authors: Raphaela Schwentner, Sven Bilke, Max Kauer, Gunhild Jug, Robert L. Walker, Paul S. Meltzer, Heinrich Kovar
Journal: Cancer Research (2012)

Abstract Ewing's sarcoma (ESFT) is a highly aggressive pediatric cancer characterized by the chimeric ETS transcription factor EWS-FLI1 as a result of a chromosomal translocation. By whole genome gene expression and ChIP-seq analyses we obtained evidence that EWS-FLI1 directly binds to 50% of E2F target genes in ESFT. Furthermore, several E2F factors were themselves found to be directly regulated by EWS-FLI1. Therefore, we studied the functional interaction of EWS-FLI1 with E2F. Ten arbitrarily chosen EWS-FLI1/E2F candidate targets including E2F3, RAD51, and ATAD2 were chosen for an in-depth promoter activity study by luciferase reporter gene assays in combination with mutation analysis of transcription factor binding motifs. By ChIP-PCR we confirmed direct EWS-FLI1 promoter binding, and observed decreased reporter activity for all ten studied promoters upon knockdown of EWS-FLI1 by RNAi. Furthermore, the study of promoter occupancy by different E2F family members revealed that silencing of EWS-FLI1 results in the exchange of EWS-FLI1 induced, activating E2F3 by constitutively expressed repressive E2F4 on the promoters of there jointly regulated target genes. Importantly, testing E2F3 promoter occupancy on wildtype and ETS motif mutated promoter constructs in ESFT cell lines revealed that binding of E2F3 to its target promoters is dependent on an intact ETS binding site. Mutation of the ETS motif resulted in reduced binding of E2F3. These data are consistent with a model in which EWS-FLI1 actively recruits an activating E2F factor thereby replacing a repressing E2F factor and in which EWS-FLI1 binding is essential for E2F binding. Strikingly, the functional E2F/ETS transcriptional module detected in ESFT for the chimeric ETS factor EWS-FLI1 was found to be also relevant to TMPRSS2-ERG expressing prostate cancer cells, but not active in HeLa cells. Supported by grants from the Austrian Science Fund (P22328-B09), and the European Comission (EU-FP7 STREP 259348). R. Schwentner is a recipient of a DOC-fFORTE-fellowship of the Austrian Academy of Sciences. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2198. doi:1538-7445.AM2012-2198
Doing What's Best for Patients: 1957 and 1997
Authors: John H. Kelly
Journal: JAMA (1997)

<h3>To the Editor.</h3> —"Doing what is best for patients"<sup>1</sup>encapsulates the essence of what is good and noble in medicine and what can set it apart as a profession. As Dr Pellegrino observes, "suppression of self-interest to that of the patient" has historically constituted the heart of every medical code. I hope the new American Medical Association (AMA) Institute of Ethics will be a significant step toward making this truly the paradigm of the AMA. Dr Siegler cites Leon Kass' observation that the practice of ethics has at best improved our speech but not our deeds and goes on to state there is much evidence that the state of ethical medical practice is no better today than 30 years ago. Could that be related to the fact that today's AMA Principles of Medical Ethics compared with those of 1957 reveal significant emaciation and diminution of the fundamental principle of
Philip R. A. May
Authors: L. J. West
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ontogeny and Oncogenesis Balance the Transcriptional Profile of Renal Cell Cancer
Authors: Ena Wang, Rudolf Lichtenfels, Jurgen Bükur, Yvonne Ngalame, Monica C. Panelli, Barbara Seliger, Francesco M. Marincola
Journal: Cancer Research (2004)

Abstract Global transcript analysis is increasingly used to describe cancer taxonomies beyond the microscopic reach of the eye. Diagnostic and prognostic portraits are formulated by ranking cancers according to transcriptional proximity. However, the role that distinct biological factors play in defining these portraits remains undefined. It is likely that the transcriptional repertoire of cancers depends, on one hand, on the anamnestic retention of their ontogenesis and, on the other, on the emergence of novel expression patterns related to oncogenesis. We compared the transcriptional profile of primary renal cell cancers (RCCs) with that of normal kidney tissue and several epithelial cancers of nonrenal origin to weigh the contribution that ontogeny and oncogenesis make in molding their genetic profile. Unsupervised global transcript analysis demonstrated that RCCs retain transcriptional signatures related to their ontogeny and cluster close to normal renal epithelium. When renal lineage-associated genes are removed from the analysis and cancer-specific genes are analyzed, RCCs segregate with other cancers with limited lineage specificity underlying a predominance of the oncogenic process over lineage specificity. However, a RCC-specific set of oncogenesis-related genes was identified and surprisingly shared by sarcomas. In summary, the transcriptional portrait of primary RCCs is largely dominated by ontogeny. Genes responsible for lineage specificity may represent poor molecular targets for immune or drug therapy. Most genes associated with oncogenesis are shared with other cancers and may represent better therapeutic targets. Finally, a small subset of genes is associated with lineage-specific oncogenesis, and these may provide information regarding the biological behavior of RCCs and facilitate diagnostic classification of RCCs.
Qualitative real-time cross-sectional echocardiographic imaging of the human fetus during the second half of pregnancy.
Authors: L W Lange, D J Sahn, H D Allen, S J Goldberg, C Anderson, H Giles
Journal: Circulation (1980)

In this study, we used high-resolution echocardiographic systems to investigate how early in pregnancy normal fetal cardiac anatomy could be noninvasively evaluated. Over a 2-year period, 84 of 88 fetuses were successfully imaged (27 were studied serially). Postnatal images of 73 were obtained during the newborn period. Estimated fetal age varied at initial examination from 19-41 weeks (mean +/- 0.5 weeks [+/- SEM]) of pregnancy. Estimated fetal weight using an ultrasound algorithm varied from 500-3100 g (mean 1580 +/- 80 g [+/- SEM]). To evaluate fetal cardiac anatomy, we reproduced commonly used cross-sectional views of the heart. The four-chamber and the short-axis great artery views have been most successful for cardiac evaluation in the fetus. These views could be obtained in 96% and 95% of the patients, respectively. With these views, cardiac chamber and valve structures, as well as two great arteries, could be imaged in detail. The ascending and descending aorta, as well as the aortic arch and vessels to the arms and head, were visualized in 87% of examinations, and the inferior and superior venae cavae were visualized in 76%. In two of three RH fetuses, changes in cardiac chambers compatible with hydrops fetalis were demonstrated. We examined all fetuses after birth and verified clinically (or noninvasively) that no cardiac malformations were present. It appears, however, that the diagnosis of major congenital heart defects should be possible before birth.
Aureomycin in the Treatment of Pneumonia in Infants and Children
Authors: Bennett Olshaker, Sidney Ross, Adrian Recinos, Ellsworth Twible
Journal: New England Journal of Medicine (1949)

AUREOMYCIN is an antibiotic derived from a strain of Streptomyces aureofaciens. The drug has been found to have a wide antibacterial spectrum against gram-positive and gram-negative organisms. In addition, it has been found to be effective against rickettsia as well as certain viruses, chiefly of the lymphogranuloma-venereum-psittacosis group.1 In man, therapeutic doses up to 60 mg. per kilogram of body weight per day given orally have not been associated with toxic manifestations except for occasional nausea, vomiting and diarrhea. These symptoms have been transient and do not contraindicate or prevent continuation of therapy.Aureomycin is absorbed readily after oral . . .
THE OCCURRENCE DURING ACUTE INFECTIONS OF A PROTEIN NOT NORMALLY PRESENT IN THE BLOOD
Authors: Harrison F. Wood, Maclyn McCarty, Robert J. Slater
Journal: The Journal of Experimental Medicine (1954)

A method is described for obtaining crystalline C-reactive protein from serous fluids in which the protein is associated with lipid. Most pathological fluids currently available as a source of this protein appear to fall in this category. Crystalline C-reactive protein has its isoelectric point at pH 4.82 as determined by free electrophoresis in McIlvaine's buffer. Its mobility in the electrophoresis cell, both alone and after addition to normal serum, coincides with that of the beta-globulin fraction of the serum. In contrast to this finding, by the method of zone electrophoresis on a starch supporting medium the protein migrates with the gamma(1)-globulin. The significance of this discrepancy is discussed. Studies in the ultracentrifuge indicate an s(20,w) of 7.5.