tbuckley/cabot-search huggingface dataset:
Abstract P1-01-01: The value of isosulphan blue dye in addition to isotope scanning in the identification of the sentinel lymph node in breast cancer patients with a positive lymphoscintigraphy: A randomised controlled trial (ISRCTN 98849733)
Authors: EA O'Reilly, N Aucharaz, G Kelly, D Al Azawi, RS Prichard, D Evoy, J Rothwell, J Geraghty, A O'Doherty, S Skehan, C Quinn, E McDermott
Journal: Cancer Research (2013)

Abstract Introduction The advent of multimodal and targeted breast cancer treatment has seen a radical shift from aggressive surgical intervention to a more minimalist approach, both within the breast and axilla. Primary among these changes is the utilisation of the sentinel lymph node biopsy (SLNB) to detect disease within the axilla and a move away from an obligatory axillary clearance when the sentinel node is positive. This depends on the accurate identification of the SLN and initial studies describe a higher identification rate and a lower false negative rate with a dual tracer identification technique. This encompasses a combination of a blue / green dye and radio-labelled isotope. The use of blue dye has been, of itself, associated with significant morbidity and therefore many clinicians may opt for single tracer identification. Aims The aim of the current study was to determine whether the addition of blue dye to radio-isotope increased the positive SLN detection rate, where the SLN was identified pre-operatively on a lymphoscintigram. Methods A prospective randomised controlled trial comparing the combined techniques of isosulphan blue dye and isotope scanning versus isotope scanning alone was performed at a single tertiary referral centre. Ethical approval was obtained prior to commencing the study from the hospital ethics committee. Enrolment commenced in March 2010 and ceased in September 2012. The study design was a randomised open label controlled parallel group trial. The primary outcome measure was the effect of the omission of the blue dye on the identification of SLN if the lymphoscintigram was positive (1 -3 nodes identified). Results A total of 673 patients were included in the final analysis with 344 patients receiving the combination (blue dye and radio-isotope) and 329 patients who received radio-isotope scanning alone. The groups were evenly matched both demographically and pathologically. The mean age was 48 years (48.3 versus 47.7 years; P = 0.47), the mean tumour size was 23.1mm (23.2mm versus 23.0mm; p = 0.89) and there was no statistically significant difference in the grade of the tumours between the two groups (p = 0.58). Overall, there was no difference in the number of nodes retrieved between the two groups (563 versus 523; p = 0.30). Similarly, there was no difference in the number of positive lymph nodes that were identified between the two groups (107 versus 98; 23.8% versus 22%; p = 0.65). Conclusions The addition of isosulphan blue dye does not aid in the identification of the SLN in patients who have a positive lymphoscintigram when radioisotope colloid is used. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P1-01-01.
Effects of short- and long-term growth hormone replacement on lipoprotein composition and on very–low-density lipoprotein and low-density lipoprotein apolipoprotein B100 kinetics in growth hormone–deficient hypopituitary subjects
Authors: Tara Kearney, Carmen Navas de Gallegos, Anthony Proudler, Kim Parker, Victor Anayaoku, Peter Bannister, Soundararajan Venkatesan, Desmond G. Johnston
Journal: Metabolism (2003)
Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro
Authors: Xingmin Feng, Sachiko Kajigaya, Elena E. Solomou, Keyvan Keyvanfar, Xiuli Xu, Nalini Raghavachari, Peter J. Munson, Thomas M. Herndon, Jichun Chen, Neal S. Young
Journal: Blood (2008)
Risk factors for medial tibial stress syndrome in physically active individuals such as runners and military personnel: a systematic review and meta-analysis
Authors: Karrie L Hamstra-Wright, Kellie C Huxel Bliven, Curt Bay
Journal: British Journal of Sports Medicine (2014)

Medial tibial stress syndrome (MTSS) is a common injury in runners and military personnel. There is a lack of agreement on the aetiological factors contributing to MTSS, making treatment challenging and highlighting the importance of preventive efforts. Understanding the risk factors for MTSS is critical for developing preventive measures. The purpose of this systematic review and meta-analysis was to assess what factors put physically active individuals at risk to develop MTSS. Selected electronic databases were searched. Studies were included if they contained original research that investigated risk factors associated with MTSS, compared physically active individuals with MTSS and physically active individuals without MTSS, were in the English language and were full papers in peer-reviewed journals. Data on research design, study duration, participant selection, population, groups, MTSS diagnosis, investigated risk factors and risk factor definitions were extracted. The methodological quality of the studies was assessed. When the means and SDs of a particular risk factor were reported three or more times, that risk factor was included in the meta-analysis. There were 21 studies included in the systematic review and nine risk factors qualified for inclusion in the meta-analysis. Increased BMI (weighted mean difference (MD)=0.79, 95% CI 0.38 to 1.20, p<0.001), navicular drop (MD=1.19 mm, 95% CI 0.54 to 1.84, p<0.001), ankle plantarflexion range of motion (ROM; MD=5.94°, 95% CI 3.65 to 8.24, p<0.001) and hip external rotation ROM (MD=3.95°, 95% CI 1.78 to 6.13, p<0.001) were risk factors for MTSS. Dorsiflexion and quadriceps-angle were clearly not risk factors for MTSS. There is a need for high-quality, prospective studies using consistent methodology evaluating MTSS risk factors. Our findings suggest that interventions focused on addressing increased BMI, navicular drop, ankle plantarflexion ROM and hip external rotation ROM may be a good starting point for preventing and treating MTSS in physically active individuals such as runners and military personnel.
Abstract PL-1: Hormones and the Breast: Local and Environmental Interactions
Authors: C Brisken, R Rajaram, A Ayyannan, M Beleut, O Yalcin
Journal: Cancer Research (2012)

Abstract A woman's reproductive history affects her risk to get breast cancer. In particular, the number of menstrual cycles she experiences correlates with risk. We use tissue recombination experiments and different mouse mutant models to discern the roles of the ovarian hormones estrogens and progesterone act in the mammary gland. While estrogens drive pubertal development, progesterone is the major driver of proliferation in the adult mammary epithelium. Both steroids rely strongly on paracrine signaling to elicit cell proliferation and other biological effects. Perinatal exposure to environmentally relevant concentrations of a high production volume chemical, bisphenol A, that is detected in human due to exposure through consumer products, results in persistent changes in the mammary gland. The cell number is increased in in adult females as is the response to progesterone. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr PL-1.
Percutaneous Transtubal Scintigraphic Assessment of Patency of Peritoneovenous Shunts
Authors: GREGORY J. TAGGART, DANIEL C. SULLIVAN, RICHARD J. GUSBERG, HAROLD O. CONN
Journal: Clinical Nuclear Medicine (1981)

Peritoneovenous shunts have been widely used in the management of patients with ascites when medical therapy has failed. Shunt malfunction is a frequent complication. Direct injection of a small amount of Tc-99m-sulfur colloid into the afferent limb of the shunt allows prompt, accurate determination of shunt patency while avoiding some of the hazards and pitfalls of previously described techniques.
False-positive Spleen Imaging
Authors: JAMES D. SLAVIN, JOHN A. VENTO, RICHARD P. SPENCER
Journal: Clinical Nuclear Medicine (1986)

Following trauma, a 35-year-old man had a falling hematocrit. Radiocolloid imaging showed a superior pole splenic defect with a bilobed appearance (suggesting nearly complete trans-section). There was a small quantity of function below the main portion of the spleen. At surgery, the spleen was noted to have marked lobulation (perhaps congenital) to account for the upper pole defect and trans-splenic appearance of a tear. A small accessory spleen was present below the main organ, mimicking the appearance of organ disruption. Cases of false-positive radiocolloid images, suggesting trauma, are rare but do occur.
PKCβ regulates ischemia/reperfusion injury in the lung
Authors: Tomoyuki Fujita, Tomohiro Asai, Martin Andrassy, David M. Stern, David J. Pinsky, Yu Shan Zou, Morihito Okada, Yoshifumi Naka, Ann Marie Schmidt, Shi-Fang Yan
Journal: Journal of Clinical Investigation (2004)

Activation of PKCβII is associated with the response to ischemia/reperfusion (I/R), though its role, either pathogenic or protective, has not been determined. In a murine model of single-lung I/R, evidence linking PKCβ to maladaptive responses is shown in the following studies. Homozygous PKCβ-null mice and WT mice fed the PKCβ inhibitor ruboxistaurin subjected to I/R displayed increased survival compared with controls. In PKCβ-null mice, phosphorylation of extracellular signal–regulated protein kinase-1 and -2 (ERK1/2), JNK, and p38 MAPK was suppressed in I/R. Expression of the immediate early gene, early growth response-1 (Egr-1), and its downstream target genes was significantly increased in WT mice in I/R, particularly in mononuclear phagocytes (MPs), whereas this expression was attenuated in PKCβ-null mice or WT mice fed ruboxistaurin. In vitro, hypoxia/reoxygenation-mediated induction of Egr-1 in MPs was suppressed by inhibition of PKCβ, ERK1/2, and JNK, but not by inhibition of p38 MAPK. These findings elucidate key roles for PKCβII activation in I/R by coordinated activation of MAPKs (ERK1/2, JNK) and Egr-1.
Consideration of Insurance Reimbursement for Physical Activity and Exercise Programs for Patients With Diabetes
Authors: Marco Pahor
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Low-level ECG potentials from body surface maps.
Authors: H V Pipberger
Journal: Circulation (1980)

valve enter this segment.Using these definitions, our cases do not have two ventricles.The chambers with the morphology similar to a left ventricle do not possess one-half of an AV valve and thus we do not consider them ventricles.In defining AV valves, we cannot examine these valves as the morphologist can, and so we must use angiographic criteria in naming them.To us a mitral valve is a valve that enters-a left ventricle and a tricuspid valve is a valve that enters the right ventricle.When both valves enter the same ventricle, we do not consider them to be either tricuspid or mitral, but as undifferentiated AV valves.The concepts referred to are not originally ours but are held, and have been reported, by others.2'3Our terminology is not that used by Dr. Van Praagh.Our points of view differ, as morphologists and angiographers differ, our definitions differ, and therefore the division of the continuum into segments will differ.We greatly respect Dr. Van Praagh's opinions and we understand his terminology, but until a worldwide consensus as to nomenclature evolves, we, as clinicians and angiographers, will continue to use that terminology we believe suited to our needs.
National Survey of Venereal Disease Treatment
Authors: Arthur C. Curtis
Journal: JAMA (1963)

THE YEARS 1946 to 1948, the period in which the highest incidence of syphilis was recorded, also witnessed the successful development of absorption-delaying vehicles which opened the door for outpatient penicillin therapy for syphilis. For the first time in the history of treatment of this disease an effective method of therapy was provided which could be administered with relative safety not only by specialists in the field, but by any qualified practitioner of medicine. The dramatic decrease in reported cases of syphilis from 1947 to 1957 is a success story in the field of public health. Although there is no question that there was a large and actual decrease in the incidence of syphilis during this era, part of the decrease in reported cases may have been due to the shift in treatment from public facilities and complete case reporting to private physicians and incomplete case reporting. Isolated surveys
Comprehensive cytogenetic study by spectral karyotyping on blastic natural killer cell leukemia/lymphoma
Authors: Naoto Jyoko, Junya Kuroda, Shinya Kimura, Yutaka Kobayashi, Toshikazu Yoshikawa
Journal: American Journal of Hematology (2002)

To the Editor: Chronic lymphocytic leukemia was diagnosed in a 63year-old female patient in May 1991.Peripheral blood smears showed increased leucocytes (18,500/ll) with up to 90% lymphocytes positive for CD 19 (97%) and CD 5 (52%).Bone marrow involvement was 80%.Initial CT scans showed multiple lymphomas at different regions enlarged up to 2 cm.Thrombocytes were slightly decreased to 127,000/ll and hemoglobin was normal with 14.3 g/dl.Treatment with chlorambucil (6 mg/m 2 p.o.; days 1À3) and prednisone (75 mg/day p.o. day 1, 50 mg/day p.o. day 2, 25 mg/day p.o. day 3) repeated every 2 weeks was initiated between December 1993 and September 1994 and between June 1996 and April 1997.In October 1998 the patient developed progressive disease with 88% lymphocytes in the peripheral blood smears, 90% bone marrow in®ltration, multiple abdominal lymphomas enlarged up to 4 cm, progressive splenomegaly and, in addition autoimmune hemolytic anemia (AIHA).Repeated treatment with chlorambucil and prednisone yielded no response.In February 1999 irradiation of the spleen (8 Gy) was initiated because of massive splenic enlargement (30 cm).During radiation therapy a dramatic aggravation of hemolysis developed.Laboratory data were: leucocytes 6,500/ll, platelets 57,000/ll, hemoglobin 5.7 g/dl, bilirubin 6.0 mg/dl, indirect bilirubin 4.9 mg/dl, haptoglobin <0.05 g/l, lactate dehydrogenase (LDH) 378 U/l.The direct Coombs test was strongly positive.Steroid dosage was increased to 40 mg dexamethasone per day for 4 days followed by 50 mg prednisone/ day.This high-dose steroid treatment initially resulted in a slight improvement of hemoglobin, but reduction of the steroid medication led to renewed aggravation of hemolysis.Also three cycles of chemotherapy with cyclophosphamide (750 mg/m 2 i.v.every 4 weeks) did
A STUDY OF TWO HUNDRED AND TWO CASES OF CONGENITAL SYPHILIS
Authors: A. BENSON CANNON
Journal: JAMA (1927)

I have had 202 cases of congenital syphilis under my care, and in making a more or less intensive study of these patients collectively as well as individually I have noted a few interesting details which I hope may be of benefit to physicians in their continued attempt to overcome the infection. For my records I endeavored to secure an accurate parental history with especial attention to the duration of the mother's infection, the amount and character of the treatment she had received, the number and order of pregnancies and the outcome of each, as well as the notation of symptoms in the syphilitic infant, and the tabulation of the character, frequency and diagnostic value of the various stigmas found in the late syphilitic patient and their influence on prognosis, serologic observations and the luetin test. <h3>INCIDENCE</h3> In 80 per cent of the mothers it was impossible to determine the
Disseminated Mycobacterium genavense infection after immunosuppressive therapy shows underlying new composite heterozygous mutations of β1 subunit of IL-12 receptor gene
Authors: Laura Tassone, Anna Cristina C. Carvalho, Alessandra Calabresi, Enrico Tortoli, Alessandra Apostoli, Omar Scomodon, Cecilia Spina, Donatella Vairo, Vincenzo Villanacci, Alberto Matteelli, Raffaele Badolato
Journal: Journal of Allergy and Clinical Immunology (2012)
Induction of right ventricular hypertrophy with obstructing balloon catheter. Nonsurgical ventricular preparation for the arterial switch operation in simple transposition.
Authors: H Katayama, R Krzeski, E G Frantz, J I Ferreiro, C L Lucas, B Ha, G W Henry
Journal: Circulation (1993)

BACKGROUND Recently, a successful result with a rapid two-stage arterial switch operation (ASO) was reported for patients with transposition of the great arteries (TGA) with low left ventricular pressure. In this procedure, the interval between pulmonary arterial banding and ASO was approximately 1 week. This successful result indicates the possibility of a nonsurgical ventricular preparation procedure using an obstructing balloon catheter prior to ASO. METHODS AND RESULTS A 5F atrioseptostomy catheter was inserted directly into the main pulmonary artery in six lambs aged 20 to 38 days. After the chest was closed, the balloon was inflated twice a day for a period of 2 to 2.5 hours. This procedure was performed for 4 consecutive days. After the final inflation, the ratio of right ventricular weight to total ventricular weight was compared with that in an age-matched control group. After the final inflation, the peak systolic right ventricular pressure and the percentage of peak systolic right ventricular to peak systolic aortic pressure rose to 85.6 +/- 4.7 mm Hg (mean +/- 1 SD) and 79.6 +/- 8.6%, respectively. The percentages of the right ventricular weight to the total ventricular weight were significantly higher after the balloon inflation than those in the control group in terms of wet heart weight (29.5 +/- 1.2% versus 23.0 +/- 1.0%; P &lt; .0001) and dry heart weight (27.0 +/- 2.0% versus 21.0 +/- 1.1%; P &lt; .0001). CONCLUSIONS The myocardial mass in the right ventricle increased after 4 days of intermittently applied pressure overload. Nonsurgical preparation of the ventricle for ASO in TGA is feasible.
Results and factors influencing outcome after fully haploidentical hematopoietic stem cell transplantation in children with very high-risk acute lymphoblastic leukemia: impact of center size: an analysis on behalf of the Acute Leukemia and Pediatric Disease Working Parties of the European Blood and Marrow Transplant group
Authors: Thomas Klingebiel, Jacqueline Cornish, Myriam Labopin, Franco Locatelli, Philippe Darbyshire, Rupert Handgretinger, Adriana Balduzzi, Joanna Owoc-Lempach, Franca Fagioli, Reuven Or, Christina Peters, Franco Aversa, Emmanuelle Polge, Giorgio Dini, Vanderson Rocha
Journal: Blood (2009)
Abstract 4493: Rapamycin enhanced in vitro and in vivo activity of dexamethasone against acute lymphoblastic leukemia and lymphoma preclincal models via inhibition of p70S6 kinase activity
Authors: YongKu Ryu, Chong Zhang, Taylor Chen, Min H. Kang
Journal: Cancer Research (2010)

Abstract Background: Glucocorticoids are an important part of therapy for lymphoid malignancies and understanding resistance mechanisms may enable designing drug combinations that will improve treatment outcome. We reported that rapamycin (RM) can enhance cytotoxicity of dexamethasone (DM) in cell culture models of lymphoid malignancies (Proc AACR 50: 4062, 2009). In the current study, we examined the mechanisms of synergy as well as in vivo activity of the DM + RM combination. Methods: Cytotoxicity of DM + RM at fixed-ratio concentrations was assessed using the DIMSCAN system in 12 acute lymphoblastic leukemia (ALL) and 3 lymphoma cell lines. Synergy was determined using the multiple drug-effect equation of Chou-Talalay with Calcusyn software. Protein was measured by immunoblotting. Phosphotransferase activity of p70 ribosomal protein S6 kinase (p70S6K) was determined using [γ-32P]ATP. In vivo drug activity was determined in NOD/SCID (ALL intravenous) and nu/nu (lymphoma, subcutaneous) mouse xenograft models. Results: DM + RM achieved cytotoxicty &amp;gt; 90% in 7 of 15 cell lines, and DM + RM was synergistic in 5 lines (combination index &amp;lt; 0.9). Among the phosphoinositide 3-kinase pathway proteins, phosphorylation of p70S6K and ribosomal protein S6 (rpS6) and also p70S6K enzyme activity was inhibited by DM + RM in those cell lines showing DM + RM synergy, but was not inhibited in lines that failed to demonstrate drug synergy. RNAi knockdown of p70S6K also significantly enhanced cytotoxicity of DM + RM in CCRF-CEM cells. In the COG-LL-317x systemic ALL and the GA-10 subcutaneous lymphoma xenograft models, DM + RM significantly (p &amp;lt; 0.01) extended the event-free survival (EFS) of mice compared with DM or RM as single agents. In the RS4;11 systemic ALL model, DM and DM + RM extended EFS (p &amp;lt; 0.01) compared with control or RM alone, although no differences in EFS was observed between DM and DM + RM. Conclusion: Our study showed that RM enhanced activity of DM in ALL and lymphoma cell lines and xenograft models and that inhibition of p70S6K activity is the molecular basis for the synergy between DM + RM in lymphoid malignancies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4493.