tbuckley/cabot-search huggingface dataset:
Expression of bcl-2 antagonist bak in inflammatory and neoplastic skin diseases
Authors: H. TOMKOVÁ, W. FUJIMOTO, J. ARATA
Journal: British Journal of Dermatology (1997)

Journal Article Expression of bcl‐2 antagonist bak in inflammatory and neoplastic skin diseases Get access H. TOMKOVÁ, H. TOMKOVÁ Department of Dermatology, Okayama University Medical School. 2‐5‐1 Shikata‐cho, 700 Okayama City, japan Search for other works by this author on: Oxford Academic Google Scholar W. FUJIMOTO, W. FUJIMOTO Department of Dermatology, Okayama University Medical School. 2‐5‐1 Shikata‐cho, 700 Okayama City, japan Search for other works by this author on: Oxford Academic Google Scholar J. ARATA J. ARATA Department of Dermatology, Okayama University Medical School. 2‐5‐1 Shikata‐cho, 700 Okayama City, japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 137, Issue 5, 1 November 1997, Pages 703–708, https://doi.org/10.1046/j.1365-2133.1997.19392054.x Published: 01 November 1997 Article history Accepted: 12 June 1997 Published: 01 November 1997
956-113 Advanced Age is not a Contraindication for Primary Infarct Angioplasty in Patients with Cardiogenic Shock
Authors: Lee F. Carter, William J. Stephan, Patricia G. Cavero, Robert W. Ligon, Thomas M. Shimshak, Lee V. Giorgi, Warren L. Johnson, Barry D. Rutherford, David R. McConahay, Geoffrey O. Hartzler
Journal: Journal of the American College of Cardiology (1995)
Medical Problems of Civil Disorders
Authors: Arthur Frank, Jesse Roth, Sidney Wolfe, Henry Metzger
Journal: New England Journal of Medicine (1969)

NEARLY every city in the United States is a likely candidate for civil disorder. Small size, geography or a previous riot apparently provide little or no immunity.1 The underlying grievances that have led to riots1 have not been redressed.Sustained violence will markedly increase the need for medical services. The primary needs will result from the violence and from the law-enforcement efforts — tear gas, blunt trauma, bullets, fire, smoke and broken glass. The associated chaos, anxiety and disruption of routine will create or aggravate other medical conditions — hypertension, asthma, diabetes and alcohol and narcotics withdrawal.Concomitantly, the health . . .
Serum Transaminase Activity in Status Asthmaticus
Authors: A. H. El-Shaboury, A. J. Thomas, D. A. Williams
Journal: BMJ (1964)

Vacuum Extractor-Chalmers MBICARJOURNAL anterior position.The more experienced practitioner may wish to extend the range of his intervention, but this should be limited to institutional conditions.There are many general practitioners in this country, including several of our former house-surgeons, who are using the instrument successfully.Further extension of this trend would help to reduce the dangers of forceps in unpractised hands and lead to improved figures for infant survival in the home, as we believe it has in the hospital.
Development and characterization of a mouse in vitro model of ischaemia-induced ventricular fibrillation
Authors: C. L. Stables, M. J. Curtis
Journal: Cardiovascular Research (2009)

We sought to generate a mouse Langendorff model of ischaemia-induced ventricular fibrillation (VF) that does not depend on triggers such as programmed electrical stimulation. Hearts from male Tuck Ordinary mice were perfused with Krebs solution (modified to contain low-normal K+, 3 mmol/L, and high Ca2+, 2.4 mmol/L) containing different combinations of catecholamines (epinephrine 313 nmol/L plus norepinephrine 75 nmol/L) and/or angiotensin II (100 pmol/L) designed to mimic the in vivo milieu. VF was absent during 30 min regional ischaemia (and during 10 min reperfusion) in Krebs-perfused hearts. Catecholamines unmasked ischaemia-induced VF (50%; P < 0.05) and reperfusion-induced VF (50%; P < 0.05). Co-perfusion with angiotensin II did not facilitate VF. Supraventricular pacing (600 b.p.m.) stabilized pre-ischaemic sinus rhythm and partially mimicked the VF-unmasking effect of catecholamines. Arrhythmia susceptibility was greatest with supraventricular pacing plus catecholamines (57% VF during ischaemia and 71% during reperfusion). For the first time, regional ischaemia-induced VF was consistently evoked in a mouse Langendorff preparation, unmasked by simple periphysiological manipulation of the perfusion conditions. The model is suitable for functional genomic studies.
504 IMPROVEMENT OF INTERFERON-BASED THERAPY SUBSTANTIALLY REDUCED THE NUMBER NEEDED TO TREAT TO PREVENT HCC AMONG HCV GENOTYPE 1 INFECTED CIRRHOTICS
Authors: A.J.P. van der Meer, B.J. Veldt, J.J. Feld, H. Wedemeyer, J.-F. Dufour, F. Lammert, A. Duarte-Rojo, M.P. Manns, S. Zeuzem, W.P. Hofmann, R.J. de Knegt, B.E. Hansen, H.L.A. Janssen
Journal: Journal of Hepatology (2013)
From Dream to Discovery: On Being a Scientist
Authors: Dwight J. Ingle
Journal: JAMA (1964)

Although this book is largely autobiographical, the narrative goes through several excursions from a deeply personal document, in which the author bares his soul, to an impersonal textbook. But most of the time the author is there—and should be, for he is a remarkable individual. The scientific discoveries of Hans Selye have had a major impact on endocrinology. He is best known for his concept of the etiology of disease. This concept has been important because it was heuristic and did indeed have elements of truth, although the search for causes of the great diseases has swept on to other levels and areas of inquiry.  Dr. Selye writes on such subjects as why one should do research, who should do research, where and when it should be done, how to work, how to think, and how to read, write, and speak. He mentions repeatedly his admiration for Walter B. Cannon,
Endothelial dysfunction and serum fatty acid composition in patients with type 2 diabetes mellitus
Authors: Magda S. Perassolo, Jussara C. Almeida, Thais Steemburgo, Valesca Dall'Alba, Vanessa D.F. de Mello, Themis Zelmanovitz, Mirela J. de Azevedo, Jorge L. Gross
Journal: Metabolism (2008)
Abstract 1300: Vascular endothelial growth inhibitor (VEGI; TNFSF15) inhibits bone marrow-derived endothelial progenitor cell incorporation into Lewis Lung cancer (LLC) tumors
Authors: Paulina H. Liang, Fang Tian, Yi Lu, Donna B. Stolz, Lu-Yuan Li
Journal: Cancer Research (2010)

Abstract Bone marrow-derived endothelial progenitor cells (EPC) have been shown to be a critical component of supporting tumor neovascularization. We have shown in a variety of cancer and angiogenesis models that recombinant vascular endothelial growth inhibitor (VEGI; TNFSF15) inhibits angiogenesis and tumor growth via specific elimination of mature endothelial cells (EC) in established tumor vasculature. We report here that VEGI treatment leads to a significantly decreased population of EPC in tumors. We transplanted whole bone marrow from green fluorescent protein (GFP) transgenic mice into C57BL/6 recipient mice. The mice were then inoculated with Lewis Lung cancer (LLC) cells and treated with VEGI or vehicle. In the tumors of the VEGI-treated group, we saw both a significant inhibition of tumor growth and decreased density of CD31+ vasculature compared to vehicle treated mice. Flow cytometric analysis of the peripheral blood of tumor bearing mice revealed an initial increase of EPCs derived from the bone marrow (GFP+Flk1+) prior to the timeframe when EPCs are incorporated into the tumor. After this timeframe, the EPC in peripheral blood decreased markedly. Monitoring for EPC by GFP+CD31+ immunostaining, we found that the number of EPC in VEGI treated tumors notably decreased compared to that of the untreated group. EPC incorporation into the tumor vasculature of VEGI-treated mice was also less than that in the untreated group. TUNEL staining of the tumor sections showed a large extent of apoptosis overall in VEGI-treated tumors. These findings indicate that VEGI plays an important role in modulating bone marrow-derived EPC incorporation into LLC carcinomas, resulting in the inhibition of EPC supported tumor vasculogenesis and tumor growth. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1300.
Assessing the Comparability of Mortality Statistics
Authors: D. D. Reid, G. A. Rose
Journal: BMJ (1964)

Case 3A woman aged 29 had an uneventful antenatal period and was admitted in the first stage of labour on her expected date of con- finement.Foetal movements had ceased early in labour, and on her admission six and a half hours before delivery no foetal heart was heard.The cervix was dilated three fingerbreadths and no cord was felt.Labour lasted 14 hours and the patient was delivered of a female stillborn infant weighing 6 lb.4--> -<-->4 | 12 oz. (3,060g.).The cord was coiled loosely once round the baby's neck and showed a swell- ing 5 cm.long near the umbilicus (see Fig.).
Time lag to benefit after screening for breast and colorectal cancer: meta-analysis of survival data from the United States, Sweden, United Kingdom, and Denmark
Authors: S. J. Lee, W. J. Boscardin, I. Stijacic-Cenzer, J. Conell-Price, S. O'Brien, L. C. Walter
Journal: BMJ (2012)

<b>Objectives</b> To determine a pooled, quantitative estimate of the length of time needed after breast or colorectal cancer screening before a survival benefit is observed. <b>Design</b> Meta-analysis of survival data from population based, randomized controlled trials comparing populations screened and not screened for breast or colorectal cancer. Trials were identified as high quality by reviews from the Cochrane Collaboration and United States Preventive Services Task Force. <b>Setting</b> Trials undertaken in the United States, Denmark, United Kingdom, and Sweden. <b>Population</b> Screened patients older than 40 years. <b>Primary outcome measures</b> Time to death from breast or colorectal cancer in screened and control populations. <b>Interventions</b> Fecal occult blood testing for colorectal cancer screening, mammography for breast cancer screening. <b>Results</b> Our study included five and four eligible trials of breast and colorectal cancer screening, respectively. For breast cancer screening, 3.0 years (95% confidence interval 1.1 to 6.3) passed before one death from breast cancer was prevented for every 5000 women screened. On average across included studies, it took 10.7 years (4.4 to 21.6) before one death from breast cancer was prevented for 1000 women screened. For colorectal cancer screening, 4.8 years (2.0 to 9.7) passed before one death from colorectal cancer was prevented for 5000 patients screened. On average across included studies, it took 10.3 years (6.0 to 16.4) before one death from colorectal cancer was prevented for 1000 patients screened. <b>Conclusions</b> Our results suggest that screening for breast and colorectal cancer is most appropriate for patients with a life expectancy greater than 10 years. Incorporating time lag estimates into screening guidelines would encourage a more explicit consideration of the risks and benefits of screening for breast and colorectal cancer.
A2.32 Experimental autoimmune arthritis in mice with cell-specific SYK-deletion
Authors: T Németh, O Vilinovszki, K Szilveszter, A Mócsai
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background and objectives</h3> Autoimmune arthritides affect a significant proportion of the population and mean heavy burdens to patients. Despite of intensive research, the underlying pathological mechanisms are not completely understood yet. Our workgroup previously published that the Syk tyrosine kinase is essential in experimental arthritis in mice. Probably, Syk expression in multiple cell lines is responsible for this effect. Neutrophils, platelets and mast cells are crucial participants in experimental arthritis and Syk is an important component of their immunoreceptor (-like) signalling pathways among <i>in vitro</i> conditions. Here, we investigated whether Syk expression is required in these cell lines for the development of autoantibody-induced arthritis. <h3>Materials and methods</h3> Neutrophil-, platelet- and mast cell-specific Syk deletion was achieved by crossing MRP8, PF4 or Mcpt5 promoter-driven Cre recombinase transgenic (MRP8-Cre, PF4-Cre or Mcpt5-Cre) animals with Syk<sup>flox/flox</sup> mice (MRP8-Cre Syk<sup>flox/flox</sup>, PF4-Cre Syk<sup>flox/flox</sup> and Mcpt5-Cre Syk<sup>flox/flox</sup>, respectively). The efficacy and specificity of lineage-specific deletion was analysed by Western-blot on neutrophil, platelet and mast cell lysates. Experimental arthritis was induced by a single intraperitoneal injection of K/BxN serum and was assessed by clinical scoring, ankle thickness measurements and by testing articular function. <h3>Results</h3> In contrast to the wild type animals, neutrophils of the MRP8-Cre Syk<sup>flox/flox</sup> mice, platelets of the PF4-Cre Syk<sup>flox/flox</sup> mice and mast cells of Mcpt5-Cre Syk<sup>flox/flox</sup> mice did not express Syk, while their macrophages had normal levels of the protein. Interestingly, PF4-Cre Syk<sup>flox/flox</sup> and Mcpt5-Cre Syk<sup>flox/flox</sup> mice showed a similar disease phenomenon as their wild type controls. The changes of the clinical score, the ankle thickening and the articular dysfunction did not differ significantly in the three groups. Meanwhile, neutrophil-specific Syk deletion resulted in a severe attenuation of the disease. <h3>Conclusions</h3> Our results indicate that − in contrast to the expectations − the presence of Syk in platelets and mast cells is not required for the development and progression of experimental arthritis, while Syk expression in neutrophils is indispensable for the pathogenesis.
Toward Fewer Procedures and Better Outcomes
Authors: Stephen C. Schoenbaum
Journal: JAMA (1993)

In 1987 and 1988 the Health Program at RAND, Santa Monica, Calif, published a series of articles on the appropriateness of various medical procedures that had been performed between 1979 and 1982.<sup>1-3</sup>The RAND investigators had developed appropriateness criteria by a specific method in which panels of nine experts reviewed relevant medical literature and then rated a series of clinical scenarios (indications). When the criteria sets were applied to actual patient records, it appeared that a significant percentage of the procedures were unnecessary. The medical and general public pounced on these reports. At last there was evidence that substantial savings might be achieved in health care; and since the savings would derive from the elimination of unnecessary care, there should actually be a concomitant increase in the quality of care. See also pp 753, 761, and 766. In this issue ofThe Journalthere are three more articles<sup>4-6</sup>
The effects of chimeric cells following donor bone marrow infusions as detected by PCR-flow assays in kidney transplant recipients.
Authors: R Garcia-Morales, M Carreno, J Mathew, K Zucker, R Cirocco, G Ciancio, G Burke, D Roth, D Temple, A Rosen, L Fuller, V Esquenazi, T Karatzas, C Ricordi, A Tzakis, J Miller
Journal: Journal of Clinical Investigation (1997)

40 recipients of first cadaver kidney transplants were given perioperative donor vertebral bone marrow infusions (DBMC), compared with 100 controls who did not receive donor bone marrow. The immunosuppressive regimen included OKT3, Tacrolimus, and steroid maintenance therapy, and, in some patients, newly introduced mycophenolate mofetil. This report describes the 24-mo actuarial follow-up and several immunological monitoring studies including sequential measurements of donor bone marrow lineage subset chimerism by the recently reported PCR-flow assay. This is a sensitive in situ PCR detection system for donor versus recipient histocompatibility genes as well as cell surface CD epitope markers using flow cytometry. The results indicate (a) the stabilization of the donor CD3+ and CD34+ cells in recipient peripheral blood at levels below 1% between 6 mo and 1 yr postoperatively, with a 10-fold higher level of donor cell chimerism of these lineages in recipient iliac crest marrow; (b) significantly lower levels of chimerism in peripheral blood up to 6 mo postoperatively in patients who had early acute (reversible) rejection episodes compared with those who did not; (c) a higher degree of chimerism seen in patients who were class II MHC HLA DR identical with their donors; (d) the identification of a high proportion of the donor bone marrow derived CD3 dimly staining subset of T cells (to which regulatory functions have been ascribed) in recipient peripheral blood and especially in recipient bone marrow; and (e) an unexpectedly increased susceptibility to clinically significant infections (primarily viral), and even death in the DBMC-infused group, compared with controls, but no graft losses because of rejection in the DBMC-infused group. Mixed lymphocyte culture assays showed a trend toward a greater number of nonspecifically low reactors in the DBMC group, as well as a greater number of nonspecifically high reactors in the controls (P = 0.058). The autologous mixed lymphocyte reaction also indicated a trend towards nonspecific immune activation in the DBMC group. Finally, anti-cytomegaloviral IgG antibody reactivity was significantly inhibited in the DBMC group 4-6 mo postoperatively (P = < 0.05). In the controls, there were no donor cell lineages detected by PCR-flow in the peripheral blood. These rather unexpected findings, indicating a more depressed cellular and humoral immune capacity in the DBMC cadaver kidney transplant recipients in this relatively early follow-up period, are discussed relevant to chimerism, MHC restriction, and suppressor activity brought about by specialized DBMC subsets, which still need to be defined.
Case 33-1976
Authors: Antone A. Medeiros, Karl H. Proppe
Journal: New England Journal of Medicine (1976)

Presentation of CaseA 31-year-old woman was admitted to the hospital because of obstruction of the superior vena cava.At the age of 11 years she had an illness characterized by pleuritic pain and low-grade fever, without arthralgia, rash or signs of carditis. An x-ray film of the chest was reported to show "a lymph node close to the heart." A diagnosis of rheumatic fever was made, and her physical activity was limited. During the succeeding years repeated x-ray films of the chest were unchanged. Ten years before admission she entered another hospital, where a thoracotomy disclosed a large, multilobular, . . .
Rapid activation of the sympathetic nervous system following coronary artery occlusion: relationship to infarct size, site, and haemodynamic impact
Authors: R. P. KARLSBERG, P. A. PENKOSKE, P. E. CRYER, P. B. CORR, R. ROBERTS
Journal: Cardiovascular Research (1979)

In order to define the temporal and quantitative relationship between the plasma concentrations of catecholamines and the extent and location of myocardial infarction, conscious dogs underwent left anterior descending or circumflex coronary occlusion with continuous haemodynamic monitoring. Plasma noradrenaline and adrenaline concentrations were measured by the serial isotope derivative method and infarction size by the creatine kinase depletion method. Rapid increases in plasma catecholamines were seen within 1 min of coronary occlusion. Within the first hour profound elevations of plasma adrenaline (10 fold) and noradrenaline (3 fold) occurred, with peak adrenaline and noradrenaline levels correlated to infarction size determined 24 h later in anterior (r =0.71; r =0.83) and posterior (r =0.89, r =0.78) infarctions. Cardiac output and mean systemic arterial blood pressure were inversely related to adrenaline (r =0.88, r =0.73) and noradrenaline (r =0.94, r =0.73) and deterioration in haemodynamics was always noted simultaneously with or preceding increases in plasma catecholamine concentrations. There were no significant differences in plasma catecholamines dependent on location of infarction. Thus, coronary occlusion in the conscious dog results in immediate haemodynamic deterioration and activation of the sympathetic nervous system, with a strong correlation between the two suggesting that activation of the sympathetic nervous system by haemodynamic reflexes may be of importance in the conscious canine model. The degree of autonomic activation within the first hour after occlusion appears to be related to the ultimate size of infarction, possibly because of the relationship between impairment of ventricular performance and infarct size.
Fatal Intoxication with 1,1-Dichloro-1-Fluoroethane
Authors: Alain Astier, François Paraire
Journal: New England Journal of Medicine (1997)

To the Editor: Hydrochlorofluorocarbons are being developed as alternative solvents for use instead of chlorofluorocarbons, which deplete stratospheric ozone and increase ultraviolet radiation at t...
S100A1 Gene Therapy Preserves in Vivo Cardiac Function after Myocardial Infarction
Authors: Sven T. Pleger, Andrew Remppis, Beatrix Heidt, Mirko Völkers, J. Kurt Chuprun, Matthew Kuhn, Rui-Hai Zhou, Erhe Gao, Gabor Szabo, Dieter Weichenhan, Oliver J. Müller, Andrea D. Eckhart, Hugo A. Katus, Walter J. Koch, Patrick Most
Journal: Molecular Therapy (2005)
FRENKEL'S TREATMENT OF ATAXIA BY MEANS OF EXERCISE.
Authors: BOERNE BETTMAN
Journal: JAMA (1897)

Heiden, Switzerland, situated 2,500 feet above the sea level, overlooking the beautiful Lake Constance and the five cantons bordering it, formerly had the reputation of being a whey cure. It became especially popular through the annual visits of Albrecht Von Graefe, the so-called "Father of Ophthalmology," who sought rest and recreation among its peaceful hills. A horde of patients and medical disciples followed in his wake, so that it soon became the Mecca for oculists and afflicted ones seeking their aid. Its excellent location, its salubrious climate and its hotel facilities induced Dr. Frenkel to select it for his field of work during the summer. During a seven weeks' sojourn at Heiden this summer, I had an opportunity, through the courtesy extended me by Dr. Frenkel, of observing daily his new method of treating locomotor ataxia due to tabes dorsalis. So excellent were some of the results obtained under my
The TLR1/2 agonist PAM3CSK4 instructs commitment of human hematopoietic stem cells to a myeloid cell fate
Authors: K De Luca, V Frances-Duvert, M-J Asensio, R Ihsani, E Debien, M Taillardet, E Verhoeyen, C Bella, S Lantheaume, L Genestier, T Defrance
Journal: Leukemia (2009)
Diagnosis and Care of Patients with Anorexia Nervosa in Primary Care Settings
Authors: Philip S. Mehler
Journal: Annals of Internal Medicine (2001)

Anorexia nervosa is a psychiatric disorder characterized by abnormal eating behaviors that results in weight loss and has serious potential medical consequences. Most of these complications are readily treatable if diagnosed and attended to early in the course of the illness. In caring for patients with anorexia nervosa, the primary care physician has several critical roles. Because patients deny the severity of their illness, they delay seeking psychiatric treatment. The primary care physician must be skilled in recognizing this disorder, as well as in diagnosing and effectively treating the medical complications while educating the patient about them. The primary care physician is also involved with arranging and coordinating a comprehensive and multidisciplinary program, including dietary and mental health treatment. The multidisciplinary team is responsible for ensuring safe weight restoration and a judicious refeeding treatment plan. In addition to establishing the diagnosis and treating the multiple medical complications associated with anorexia nervosa, the primary care physician plays a central role in maintaining continuity of care despite the fact that successful care may require a variety of treatment settings. Factors that foster good prognoses for this increasingly common and often protracted eating disorder include early diagnosis and skilled medical intervention to prevent the inexorable physical decline that marked weight loss can cause.