CHANGING CONCEPTS IN THE TREATMENT OF PULMONARY TUBERCULOSIS
Authors: IRVING KASS
Journal: Annals of Internal Medicine (1957)

Article1 October 1957CHANGING CONCEPTS IN THE TREATMENT OF PULMONARY TUBERCULOSISIRVING KASS, M.D., WILLIAM F. RUSSELL JR., M.D., ANGELINE HEATON, M.D., TERUMASA MIYAMOTO, M.D., GARDNER MIDDLEBROOK, M.D., SIDNEY H. DRESSLER, M.D.IRVING KASS, M.D.Search for more papers by this author, WILLIAM F. RUSSELL JR., M.D.Search for more papers by this author, ANGELINE HEATON, M.D.Search for more papers by this author, TERUMASA MIYAMOTO, M.D.Search for more papers by this author, GARDNER MIDDLEBROOK, M.D.Search for more papers by this author, SIDNEY H. DRESSLER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-4-744 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe therapy of tuberculosis has undergone a remarkable change since the advent of antimicrobials, particularly isoniazid. Cornerstones of past treatment have in many instances been relegated to ancillary rôles. The changing concepts which, in our opinion, have contributed to a decrease in the incidence of therapeutic failures are:1. "Adequate" combined drug therapy.2. Determination of the dosage of isoniazid by assay methods to insure adequate levels of the antimicrobially active drug in vivo.3. Physical activity as a basic principle of treatment.4. Surgery for the significant residual pulmonary lesion."ADEQUATE" COMBINED DRUG THERAPYThere is widespread acceptance of...Bibliography1. KarlsonPfuetzeCarrFeldmanHinshaw AGKHDTWHHC: The effect of combined therapy with streptomycin, para-aminosalicylic acid and promin on the emergence of streptomycin-resistant strains of tubercle bacilli: a preliminary report, Proc. Staff Meet., Mayo Clin. 24: 85, 1949. MedlineGoogle Scholar2. 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Mitchell RS: Mortality and relapse of uncomplicated advanced pulmonary tuberculosis before chemotherapy: 1,504 consecutive admissions followed for fifteen to twenty-five years, Am. Rev. Tuberc. 72: 487, 1955. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: IRVING KASS, M.D.; WILLIAM F. RUSSELLJR., M.D.; ANGELINE HEATON, M.D.; TERUMASA MIYAMOTO, M.D.; GARDNER MIDDLEBROOK, M.D.; SIDNEY H. DRESSLER, M.D.Affiliations: Denver, Colorado*From the Symposium on the Treatment of Tuberculosis, presented at the Thirty-eighth Annual Session of The American College of Physicians, Boston, Massachusetts, April 10, 1957.From the National Jewish Hospital at Denver and the University of Colorado School of Medicine.Requests for reprints should be addressed to Irving Kass, M.D., Assistant Medical Director, National Jewish Hospital, 3800 E. Colfax Ave., Denver 6, Colorado. 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PART IIThe treatment of tuberculous pericarditisDer Blutspiegel des INH bei Erwachsenen und KindernThe Residual Lesion in Pulmonary Tuberculosis Requiring SurgeryTuberculosis todayThe treatment of pulmonary Tuberculosis at work: A controlled trialSafe high dosage isoniazid therapyAdrenocortical steroid therapy and chemotherapy in acute, far-advanced toxic pulmonary tuberculosisBacteriology of Tuberculosis: Laboratory MethodsThe antibacterial therapy of tuberculosis 1 October 1957Volume 47, Issue 4Page: 744-761KeywordsAntimicrobialsDrug therapyDrugsExerciseHospital medicineIsoniazidLesionsSurgeryTuberculosis ePublished: 1 December 2008 Issue Published: 1 October 1957 PDF downloadLoading ...