tbuckley/cabot-search huggingface dataset:
Reversible Perfusion Disorder on Brain SPECT After Treatment With Prednisone in Temporal Arteritis
Authors: PAUL L.J. DAUTZENBERG, JAN P.A.M. LEIJTENS
Journal: Clinical Nuclear Medicine (1995)

An 81-year-old woman underwent brain SPECT because of an acute onset of dementia within weeks. Clinically, the dementia was of vascular origin. Contrary to this, the SPECT showed less perfusion in both parietal regions, suggesting Aizheimer disease. Because of a biopsy-proven temporat arteritis, she received corticosteroids and the dementia was partly reversed. After 1 year of treatment, a second SPECT showed the same perfusion disorder on the left side, but also clearly showed a better perfusion on the right side. This finding suggests that SPECT supports clinical improvement of cerebral functions after treatment of temporal arteritis with corticosteroids.
Verapamil acutely reduces ventricular-vascular stiffening and improves aerobic exercise performance in elderly individuals
Authors: Chen-Huan Chen, Masaru Nakayama, Maurice Talbot, Erez Nevo, Barry Fetics, Gary Gerstenblith, Lewis C Becker, David A Kass
Journal: Journal of the American College of Cardiology (1999)

OBJECTIVES We tested the hypothesis that acute intravenous verapamil acutely enhances aerobic exercise performance in healthy older individuals in association with a combined reduction of ventricular systolic and arterial vascular stiffnesses. BACKGROUND Age-related vascular stiffening coupled with systolic ventricular stiffening may limit cardiovascular reserve and, thus, exercise performance in aged individuals. METHODS Nineteen healthy volunteers with mean age 70 ± 10 years underwent maximal-effort upright ergometry tests on two separate days after receiving either 0.15 mg/kg i.v. verapamil or 0.5 N saline in a double-blind, randomized, crossover study. RESULTS Baseline vascular stiffness, indexed by arterial pulse-wave velocity (Doppler) and augmentation index (carotid tonometry) declined with verapamil (−5.9 ± 2.1% and −31.7 ± 12.8%, respectively, both p < 0.05). Preload-adjusted maximal ventricular power, a surrogate for ventricular end-systolic stiffness, also declined by −9.5 ± 3.6%. Peripheral resistance and peak filling rate were unchanged. With verapamil, exercise duration prior to the anaerobic threshold (AT) increased by nearly 50% (260 ± 129 to 387 ± 176 s) with a corresponding 13.4 ± 4.7% rise in oxygen consumption (V̇O2) at that time (both p < 0.01). Total exercise duration prolonged by +6 ± 2.7% (p < 0.05) with no change in maximal V̇O2. Baseline cardiodepression from verapamil reversed by peak exercise with net increases in stroke volume and cardiac output (p < 0.05). CONCLUSIONS Acute intravenous verapamil reduces ventriculovascular stiffening and improves aerobic exercise performance in healthy aged individuals. This highlights a role for heart-arterial coupling in modulating exertional capacity in the elderly, suggesting a potentially therapeutic target for aged individuals with exertional limitations.
Mathematical coupling explains dependence of oxygen consumption on oxygen delivery in ARDS.
Authors: P T Phang, K F Cunningham, J J Ronco, B R Wiggs, J A Russell
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Because of potential for mathematical coupling of measurement errors in shared variables used to calculate oxygen consumption (FickVO2) and oxygen delivery (DO2), we asked whether determination of the FickVO2-DO2 relationship in individual patients with ARDS was statistically valid. We studied 17 clinically resuscitated patients with severe ARDS, measuring FickVO2, CalorimetricVO2 (using analysis of respiratory gases), and DO2 at regular intervals while DO2 was increased using an infusion of dobutamine. Overall, we found that DO2 (pre 482 +/- 143, post 616 +/- 170 ml O2/min.m2, p < 0.01) and FickVO2 (pre 130 +/- 23, post 147 +/- 24 ml O2/min.m2, p < 0.02) increased significantly with dobutamine infusion, but CalorimetricVO2 measured simultaneously did not change (pre 128 +/- 22, post 128 +/- 22 ml O2/min x m2, p = NS). In addition, unpooled weighted slope for FickVO2 versus DO2 (0.06) was significantly different from zero, but unpooled weighted slope for CalorimetricVO2 versus DO2 (0.01) was not significantly different from zero. Slopes of the FickVO2-DO2 relationship were significant for only three individual patients. Using methods by Stratton and colleagues to analyze the effect of mathematical coupling in the FickVO2-DO2 relationship, we found that in all patients the slope of measurement errors was greater than observed slope and that observed slope was greater than estimated true slope. Estimated true slope of the FickVO2-DO2 relationship in all individual patients was not significant. Therefore, we suggest that determination of the FickVO2-DO2 relationship in individual patients who are resuscitated and hemodynamically stable is most often not statistically significant.(ABSTRACT TRUNCATED AT 250 WORDS)
Risk Factors for Development of Incipient and Overt Diabetic Nephropathy in Type 1 Diabetic Patients
Authors: Peter Rossing, Philip Hougaard, Hans-Henrik Parving
Journal: Diabetes Care (2002)

OBJECTIVE—To evaluate prospectively putative risk factors for development of microalbuminuria and macroalbuminuria in type 1 diabetes. RESEARCH DESIGN AND METHODS—Prospective observational study of a cohort of type 1 diabetic patients followed in the outpatient clinic at Steno Diabetes Center for ≤10 years (median 9 years). We followed 537 patients aged ≥18 years with type 1 diabetes, with duration of diabetes ≥5 years, with normoalbuminuria (urinary albumin excretion rate ≤30 mg/24 h), and who were not taking antihypertensive medication. Risk factors for development of microalbuminuria and macroalbuminuria were evaluated. RESULTS—The mean progression of urinary albumin excretion rate was 7.6% (SE 0.8) per year. During follow-up, 134 patients (25%) progressed to persistent microalbuminuria or macroalbuminuria (&amp;gt;30 mg/24 h in two of three consecutive urine samples). Cox multiple regression analysis using baseline values of putative predictors of progression showed the following significant predictors of progression from normoalbuminuria to microalbuminuria or macroalbuminuria: baseline log urinary albumin excretion rate 2.63 (relative risk; 95% CI 1.65–4.19), HbA1c 1.13% (1.04–1.23), presence of any retinopathy 1.90 (1.26–2.88), and smoking 1.61 (1.11–2.33). Sex, duration of diabetes, arterial blood pressure, serum creatinine, height, and social class were not risk factors. CONCLUSIONS—Our study suggests that several potentially modifiable risk factors predict the development of microalbuminuria and macroalbuminuria in type 1 diabetic patients.
More Yellow Ovaries
Authors: J. G. Wingfield
Journal: JAMA (1990)

<h3>To the Editor.—</h3> A case of unilateral yellow pigmentation of the ovary was reported recently.<sup>1</sup>We wish to add two cases in which the total ovarian substance was pigmented; neither case was associated with symptoms or pathological findings. <h3>Report of Cases.— Case 1.—</h3> A 29-year-old woman presented with primary infertility of 6 years' duration. Her cycle was regular, with occasional midcycle ovulatory bleeding. She had been examined outside the United Kingdom, with a dilatation and curettage reported as normal and a hysterosalpingogram that apparently showed bilateral tubal obstruction. She was admitted for laparoscopy, dilatation and curettage, and a dye test, which showed a uterus enlarged to about 8 weeks' size by multiple small fibroids. The tubes looked normal, but there was no spill of dye. The ovaries were of normal dimensions, the left containing a corpus luteum, but both were bright orange-yellow. The dilatation and curettage produced
Coronary Magnetic Resonance Angiography for the Detection of Coronary Stenoses
Authors: W. Yong Kim, Peter G. Danias, Matthias Stuber, Scott D. Flamm, Sven Plein, Eike Nagel, Susan E. Langerak, Oliver M. Weber, Erik M. Pedersen, Matthias Schmidt, René M. Botnar, Warren J. Manning
Journal: New England Journal of Medicine (2001)

An accurate, noninvasive technique for the diagnosis of coronary disease would be an important advance. We investigated the accuracy of coronary magnetic resonance angiography among patients with suspected coronary disease in a prospective, multicenter study.
NUTRITION AND INFECTION
Authors: S. W. CLAUSEN
Journal: JAMA (1935)

The idea that a normal state of nutrition confers resistance to infection has long been held. Following the discovery of the accessory food elements, since 1900 an enormous amount of study has been devoted both to the defining of the various nutritional deficiencies and to a search for those food factors which might promote resistance. In this work, experiments with animals have been indispensable and have led to the solution of some of the clinical problems. It has been found that (1) outspoken deficiencies may lower resistance to infection; (2) increased feeding of such food elements as vitamin A to the normal animal may not increase resistance; (3) the results obtained with one species do not necessarily apply to another species; (4) very few studies have been made in animals receiving a diet only partially deficient, yet partial deficiency in man is far more frequent than total deficiency; (5) multiple
<i>Mycobacterium tuberculosis</i>, but Not Vaccine BCG, Specifically Upregulates Matrix Metalloproteinase-1
Authors: Paul T. G. Elkington, Robert K. Nuttall, Joseph J. Boyle, Cecilia M. O'Kane, Donna E. Horncastle, Dylan R. Edwards, Jon S. Friedland
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Pulmonary cavitation is fundamental to the global success of Mycobacterium tuberculosis. However, the mechanisms of this lung destruction are poorly understood. The biochemistry of lung matrix predicts matrix metalloproteinase (MMP) involvement in immunopathology.We investigated gene expression of all MMPs, proteins with a disintegrin and metalloproteinase domain, and tissue inhibitors of metalloproteinases in M. tuberculosis-infected human macrophages by real-time polymerase chain reaction. MMP secretion was measured by zymography and Western analysis, and expression in patients with pulmonary tuberculosis was localized by immunohistochemistry.MMP-1 and MMP-7 gene expression and secretion are potently upregulated by M. tuberculosis, and no increase in tissue inhibitor of metalloproteinase expression occurs to oppose their activity. Dexamethasone completely suppresses MMP-1 but not MMP-7 gene expression and secretion. In patients with active tuberculosis, macrophages express MMP-1 and MMP-7 adjacent to areas of tissue destruction. MMP-1 but not MMP-7 expression and secretion are relatively M. tuberculosis specific, are not upregulated by tuberculosis-associated cytokines, and are prostaglandin dependent. In contrast, the vaccine M. bovis bacillus Calmette-Guérin (BCG) does not stimulate MMP-1 secretion from human macrophages, although M. tuberculosis and BCG do upregulate MMP-7 equally. BCG-infected macrophages secrete reduced prostaglandin E2 concentrations compared with M. tuberculosis-infected macrophages, and prostaglandin pathway supplementation augments MMP-1 secretion from BCG-infected cells.M. tuberculosis specifically upregulates MMP-1 in a cellular model of human infection and in patients with tuberculosis. In contrast, vaccine BCG, which does not cause lung cavitation, does not upregulate prostaglandin E2-dependent MMP-1 secretion.
A morphometric study of the endoplasmic reticulum in human hepatocytes : Correlation between morphological and biochemical data in subjects under treatment with certain drugs
Authors: A. M. Jezequel, M. Koch, F. Orlandi
Journal: Gut (1974)

The distribution of the endoplasmic reticulum in human hepatocytes is defined in quantitative terms using the techniques of morphometry. The subjects of the study are liver biopsies from normal, untreated subjects and patients being treated with various drugs. In contrast to rat hepatocytes, the amount of smooth endoplasmic reticulum (SER) in man exceeds that of the rough endoplasmic reticulum (RER) and accounts for 76·3% of the total endoplasmic reticulum. This is to be taken into consideration in pharmacological or toxicological studies. In addition, two components of the SER have been identified: more prominent is the type 1 or vesicular which has a regular honeycomb pattern, made up of cisternae with patent lumina and a mean width of 1500 A; the type 2, or non-vesicular, occurs in discrete foci of densely packed smooth membranes with a spacing of about 140 A. In subjects under short-term treatment with Benzodiazepin (diazepam) the RER remained unchanged but the SER membranes were significantly increased with a remarkable, two-to threefold increase of the SER type 2 in three out of four patients. A rise in incorporation of <sup>14</sup>C-acetate into digitonin-precipitable sterols as measured in liver biopsy material was also noted in these three patients. The suggestion is made that the SER 2 represents the newly formed membranes whereas the SER 1 would represent `adult9 membranes. No changes were observed in two patients under short-term treatment with phenobarbital or Dilantin.
807 IMPACT OF VIRAL LOAD AND CIRRHOSIS ON TREATMENT OUTCOME IN HCV GENOTYPE 3-INFECTED PATIENTS: RESULTS OF THE CANADIAN POWER PROGRAM
Authors: P.J. Marotta, C.L. Cooper, L.J. Scully, D.K. Wong, R.N. Woolstencroft, N. Abadir, R.J. Bailey
Journal: Journal of Hepatology (2008)
Lumbar epidural analgesia in labour.
Authors: B Hibbard, J F Pearson, S M Walker, J B Weaver, G A Rees, M Rosen
Journal: BMJ (1977)

Lumbar epidural analgesia in labour SIR,-Dr I D Hoult and his colleagues (1 January, p 14) focus attention on an important question concerning the safety of epidural block.Does an increased incidence of forceps delivery, and especially with Kielland's for-
Reducing greenhouse gases will have good short term effect
Authors: T. Sheldon
Journal: BMJ (2000)

Reducing greenhouse gases would have immediate as well as long term health benefits, the World Health Organization (WHO) argued at the climate change summit.

Researchers pointed to a growing body of scientific evidence attributing deaths to air pollution. Reducing greenhouse gases, they argued, also meant cleaner air, and targeting fossil fuel emissions in particular had dramatic health benefits.

Initial results from a study of eight Italian cities suggest that 4.7% of total mortality—3500 deaths annually in a population of 11 …
Malabsorption Related to Total Enzyme Output in Chronic Pancreatitis.
Authors: E. P. DiMagno
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Malabsorption Related to Total Enzyme Output in Chronic Pancreatitis.E. P. DiMagno, M.D., V. L. W. Go, M.D., W. H. J. Summerskill, M.D.E. P. DiMagno, M.D.Search for more papers by this author, V. L. W. Go, M.D.Search for more papers by this author, W. H. J. Summerskill, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-859_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo investigate the reserve capacity of the exocrine pancreas, the relationship of steatorrhea (fecal fat > 7 g/day) and creatorrhea (fecal nitrogen > 2.5 g/day) to lipase and trypsin outputs was studied in 17 patients with chronic pancreatitis and seven healthy subjects. Stools were collected for 48 hours while a standard diet was ingested. Total enzyme outputs in response to duodenal perfusion of essential amino acid (78 mM) and intravenously administered CCK-PZ (0.25 units/kg body weight·min) were compared in all patients and subjects by methods previously validated (Go et al., J Clin Invest 49:1558, 1970). Both reflex CCK-PZ and direct... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRelations between Pancreatic Enzyme Outputs and Malabsorption in Severe Pancreatic Insufficiency 1 May 1972Volume 76, Issue 5Page: 859-859KeywordsAmino acidsChronic pancreatitisDietEnzymesFatsLipasesPancreasReflexes Issue Published: 1 May 1972 PDF DownloadLoading ...
Comparative diagnostic accuracy of barium meal and endoscopy.
Authors: P B Cotton
Journal: BMJ (1976)

lowest saralasin infusion rate.At the higher in- fusion rates blood pressure decreased continuously to a minimum of 75/55 mm Hg at the end of the infusion period.At that moment the patient felt seriously ill, had a pale complexion, and vomited several times.After the infusion was stopped the blood pressure reached its preinfusion level within 30 min.Plasma renin activity (PRA) was measured at the beginning and the end of each infusion (see table ).PRA (,ug'l 3 h) BeforeAfter saralasin saralasinModerate sodium intake 10 6 3 After six days' chlorthalidone 100 mg, day 40 > 125The findings in this patient show firstly that saralasin infusion may lead to a potentially hazardous initial rise in blood pressure when PRA is low, as has been demonstrated by others,2 and secondly that saralasin infused after severe sodium depletion with chlor- thiazide diuretics and vigorously stimulated PRA may cause severe hypotension even at low-dose infusion rates.
Bee Sting Dysphagia
Authors: Dhiren Shah
Journal: Annals of Internal Medicine (1998)

Letters1 August 1998Bee Sting DysphagiaDhiren Shah, MD and Tat-Kin Tsang, MDDhiren Shah, MDNorthwestern University Medical School; Evanston, IL 60201Search for more papers by this author and Tat-Kin Tsang, MDNorthwestern University Medical School; Evanston, IL 60201Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-3-199808010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A 35-year-old man presented to the emergency department with acute dysphagia. He had left a half-filled can of orange soda on a picnic table to continue work and 2 hours later returned for a break. He was drinking the soda through a straw when he developed a foreign-body sensation in the back of his throat accompanied by dysphagia. The patient then vomited, with an unexpected finding of two bees. His symptoms progressed, prompting him to seek urgent medical attention.On physical examination, the patient was not in acute distress and had normal vital signs. No oral swelling, ...References1. Lynch JP, Rothstein RD. A gastric “bee-zoar.” N Engl J Med. 1997; 336:1763-4. Google Scholar2. Girardi A. The bee: an unusual gastric foreign body [Letter]. Endoscopy. 1990; 22:240. Google Scholar3. Butterton JR, Clawson-Simons J. Hymenoptera uvulitis [Letter]. N Engl J Med. 1987; 317:1291. Google Scholar Author, Article, and Disclosure InformationAffiliations: Northwestern University Medical School; Evanston, IL 60201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoBee Sting Dysphagia Gloria DeGrandi-Hoffman and Richard F. Hoffman Bee Sting Dysphagia Macy I. Levine Bee Sting Dysphagia Dhiren Shah and Tat-Kin Tsang Metrics Cited ByArthropod Envenomation and ParasitismBee stings of children: when to perform endotracheal intubation?Importance of Proper Identification of Stinging InsectsH.C. George Wong, MDBee Sting DysphagiaGloria DeGrandi-Hoffman, PhD and Richard F. Hoffman, MDBee Sting DysphagiaMacy I. Levine, MD 1 August 1998Volume 129, Issue 3Page: 253KeywordsBeesDysphagiaEdemaEmergency departmentLungsOropharynxPharynxSteroidsStomachVital signs Issue Published: 1 August 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
FK506 independently upregulates transforming growth factor beta and downregulates inducible nitric oxide synthase in cultured human keratinocytes: possible mechanisms of how tacrolimus ointment interacts with atopic skin
Authors: C-C.E. Lan, Y-H. Kao, S-M. Huang, H-S. Yu, G-S. Chen
Journal: British Journal of Dermatology (2004)

Journal Article FK506 independently upregulates transforming growth factor β and downregulates inducible nitric oxide synthase in cultured human keratinocytes: possible mechanisms of how tacrolimus ointment interacts with atopic skin Get access C‐C.E. Lan, C‐C.E. Lan Department of Dermatology, Kaohsiung Medical University, 100 Shih‐Chuan 1st Rd, Kaohsiung, Taiwan *Department of Dermatology, College of Medicine, National Taiwan University, Taipei, Taiwan Search for other works by this author on: Oxford Academic Google Scholar Y‐H. Kao, Y‐H. Kao Department of Dermatology, Kaohsiung Medical University, 100 Shih‐Chuan 1st Rd, Kaohsiung, Taiwan *Department of Dermatology, College of Medicine, National Taiwan University, Taipei, Taiwan Search for other works by this author on: Oxford Academic Google Scholar S‐M. Huang, S‐M. Huang Department of Dermatology, Kaohsiung Medical University, 100 Shih‐Chuan 1st Rd, Kaohsiung, Taiwan *Department of Dermatology, College of Medicine, National Taiwan University, Taipei, Taiwan Search for other works by this author on: Oxford Academic Google Scholar H‐S. Yu, H‐S. Yu Department of Dermatology, Kaohsiung Medical University, 100 Shih‐Chuan 1st Rd, Kaohsiung, Taiwan *Department of Dermatology, College of Medicine, National Taiwan University, Taipei, Taiwan Search for other works by this author on: Oxford Academic Google Scholar G‐S. Chen G‐S. Chen Department of Dermatology, Kaohsiung Medical University, 100 Shih‐Chuan 1st Rd, Kaohsiung, Taiwan *Department of Dermatology, College of Medicine, National Taiwan University, Taipei, Taiwan Gwo‐Shing Chen. E‐mail: d700086@cc.kmu.edu.tw Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 151, Issue 3, 1 September 2004, Pages 679–684, https://doi.org/10.1111/j.1365-2133.2004.06109.x Published: 01 September 2004 Article history Accepted: 08 February 2004 Published: 01 September 2004
718 PUTATIVE ASSOCIATION OF DNA METHYLTRANSFERASE 1 (DNMT1) POLYMORPHISM WITH RISK OF HUMAN HEPATOCELLULAR CARCINOMA AMONG CHRONIC HBV PATIENTS
Authors: J.-Y. Chun, J.S. Bae, T.J. Park, J.Y. Kim, B.L. Park, H.S. Cheong, S.J. Yu, J.S. Kim, S.Y. Hwang, H.Y. Kim, G.E. Chung, J.-H. Lee, H.-S. Lee, Y.J. Kim, H.D. Shin
Journal: Journal of Hepatology (2010)
Medical Obligations Imposed by Abortion
Authors: F. J. Ingelfinger
Journal: New England Journal of Medicine (1971)

A society that is at present almost casual in its acceptance of abortion may be jarred by the hard, conservative lines taken by an essayist, an editorialist, and a correspondent in this week's issue of the Journal. Abortion for reasons other than the mother's health is labeled a killing that the doctor has no right to arrange. Is this the doctrine of a few isolated religious die-hards? Apparently not. Ramsey, professor of Christian ethics at Princeton, and Dyck, Saltonstall Professor of Population Ethics at Harvard School of Public Health and member of the Divinity School Faculty at Harvard, would . . .
Bilateral Polycystic Disease of Kidney Complicated by Intestinal Obstruction
Authors: P. W. Bedford
Journal: BMJ (1958)

five years.Three further cases are presented; one is the first reported case of coma in juvenile myxoedema, another the second case reported to have survived.This patient is still alive nine months after starting treatment.The treatment is reviewed and discussed.It is sug- gested that hypothermia in itself is an indication for immediate treatment, that the application of external warmth is unwarranted, and that thyroid hormone be given in a dosage related to the degree of hypothermia.I wish to express my appreciation o' the valuable assistance given by Dr. Peter Harvey, consultant pathologist, who carried out the post-mortem examinations and microhistology.I am in-