tbuckley/cabot-search huggingface dataset:
Abstract 874: Low plasma coenzyme Q10 levels and breast cancer risk in Chinese women: Influence of menopausal status
Authors: Robert V. Cooney, Qi Dai, Yu-Tang Gao, Wong-Ho Chow, Xiao-Ou Shu, Honglan Li, Butian Ji, Qiuyin Cai, Adrian A. Franke, Wei Zheng
Journal: Cancer Research (2010)

Abstract Coenzyme Q10 (CoQ10) is an essential component of mitochondrial ATP synthesis and an important cellular antioxidant. Decreased circulating levels of CoQ10 have been associated with increased cancer incidence and poor prognosis for a number of cancer types. Limited clinical data suggest that supplemental CoQ10 may benefit breast cancer patients, as evidenced by regression of cancer and increased survival. We prospectively examined the association of plasma CoQ10 with breast cancer risk in a nested case-control study within the Shanghai Women's Health Study. Pre-diagnostic plasma samples were obtained from 373 cases and 740 age-matched controls and analyzed for total CoQ10 by HPLC with UV detection after precolumn coulometric oxidation. A risk reduction of borderline significance was associated with increasing plasma CoQ10 level using a conditional logistic regression model adjusted for age. Analysis by menopausal status revealed approximately a 50% reduction in odds ratio for pre-menopausal women in the highest quartiles of plasma CoQ10 compared to those with the lowest (p for trend = 0.01). In contrast, no significant reduction in risk was observed for post-menopausal women with increasing plasma CoQ10. Adjustment of the model for age, education, age at menarche, age at 1st live birth, months of breast feeding, history of fibroadenoma, first degree family cancer history, smoking history, and use of hormone replacement therapy yielded similar results: a significant inverse trend for breast cancer risk with increasing plasma CoQ10 in pre-menopausal women (p = 0.03) and no association for post-menopausal women. The data suggest that future epidemiologic studies of CoQ10 and breast cancer for pre-menopausal women are warranted and highlight the need for greater understanding of the origins and physiologic meaning of circulating CoQ10 in humans. This work was supported by NIH Grants CA 132149 (RVC), CA106591 (QD), and CA70867 (WZ). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 874.
The relationship between different adaptational changes and injury in the dominant shoulder of female overhead athletes
Authors: K Tonin, K Stražar, G Vidmar, I Tomšič, H Burger
Journal: British Journal of Sports Medicine (2011)

Background Adaptational changes (gleno-humeral internal rotation deficit – GIRD, SICK scapula signs and muscular imbalances) develop in the dominant shoulder of overhead athletes. Objective To evaluate the incidence and the correlation between different adaptational changes and injury in the dominant shoulder. To evaluate the effect of (a)symmetrical hand-use on the development of adaptational changes and shoulder injury. Design Observational cross-sectional correlational study. Setting and participants 36 highly competitive female overhead athletes (21 handball players, 15 volleyball players), competing in Middle European volleyball league, EHF women's champions league and Slovene National leagues and National cups. Players were divided into two groups by the symmetry of hand-use. Interventions Participants completed a self-reported shoulder history questionnaire. Complete clinical examination of the shoulders was performed, including passive internal (IR) and external rotation (ER), SICK scapula and GIRD evaluation. Isokinetic testing of IR and ER was performed in concentric (c) and eccentric (e) modes at two testing speeds (60°/s, 150°/s). Fatiguability of IR and ER was measured. Stability spiking (eER/cIR) and cocking ratios (eIR/cER) were calculated. Results All participants had decreased IR and increased ER ROM in dominant shoulders (p&gt;0.001). Average GIRD was 20.6°, greater GIRD correlated with higher cIR peak torques (p=0.008). Dominant hand eER peak torques were lower, hence the spiking ratios were lower (p=0.015 and p=0.002). Players with previous injury showed more scapular abduction, increased ER and lower cocking ratios (p=0.04, p=0.036, p=0.06). Players with asymmetrical hand-use showed higher fatiguability of IR and ER (p=0.019, p=0.01). Conclusions Static and dynamic adaptational changes are found in the dominant shoulder and are positively correlated to each other and to history of injury. Hitters and throwers fatigue more. Preventive shoulder training is crucial for injury prevention of highly competitive overhead athletes with existing adaptational changes.
Effects of local administration of hydrocortisone on cartilage degradation in vivo.
Authors: A D Sedgwick, Y M Sin, A R Moore, J C Edwards, D A Willoughby
Journal: Annals of the Rheumatic Diseases (1984)

The effect of corticosteroid on autologous minced cartilage transplanted into facsimile synovial cavities has been studied. The soluble form of hydrocortisone, as the sodium succinate, reduced proteoglycan loss from cartilage in a dose-dependent manner. In contrast, insoluble hydrocortisone acetate, if given directly into the cartilage-containing cavity, enhanced proteoglycan loss. Injection of the same dose of drug into the inflamed lining tissue reversed this effect. These findings suggest that intra-articular steroid injection may enhance cartilage damage if insoluble preparations are used, but that this may be overcome by injecting into the inflamed lining tissue rather than into the cavity itself.
Menopausal therapy and endometrial pathology.
Authors: I Craft, J Swinhoe, C J Mugglestone
Journal: BMJ (1978)

A report is made of a pilot study on the effect of administration of a cyclical or continuous course of a combined estrogen and progesterone preparation on bleeding patterns and the endometrium. Small treatment groups received either 1) cyclical estradiol valerate 2 mg plus norgestrel .5 mg for 21 of 28 days; 2) continuous estradiol valerate 2 mg plus norgestrel .5 mg daily; 3) continuous estradiol valerate 1 mg twice daily plus levonorgestrel .25 mg daily; 4) cyclical estradiol valerate 2 mg plus norethisterone acetate 1 mg for 21 of 28 days; or 5) continuous estradiol valerate 2 mg plus norethisterone acetate 1 mg daily. Withdrawal bleeding occurred in all but 1 cyclical patient, but unscheduled bleeding occurred in most continuous patients. In 2 patients, pretreatment hyperplasia had changed to proliferative in 1 and secretory in the other in 6 months of treatment (1 cyclical and the other continous). All pretreatment currettings with proliferative endometrium became secretory endometrium after treatment. It is concluded that cyclical therapy of a combined estrogen and progesterone is least likely to be acceptable to the patient. The advantages of combined versus sequential administrations and optimal doses remains to be determined.
Premenarchal Breast Nodules
Authors: Robert D. Allaben
Journal: JAMA (1979)

To the Editor.—  In addition to the proper answers to the question regarding a breast nodule in a premenarchal girl (241:1621, 1979), I believe there is another cause of unilateral breast nodules. This is local self-trauma. It usually occurs in the breast opposite the child's handedness and often is seen when the child has a sibling or good friend who is beginning to experience normal breast development. The treatment is reassurance of the child as well as the parents.
Sub-100nm gold nanomatryoshkas improve photo-thermal therapy efficacy in large and highly aggressive triple negative breast tumors
Authors: Ciceron Ayala-Orozco, Cordula Urban, Sandra Bishnoi, Alexander Urban, Heather Charron, Tamika Mitchell, Martin Shea, Sarmistha Nanda, Rachel Schiff, Naomi Halas, Amit Joshi
Journal: Journal of Controlled Release (2014)
Long circulating biodegradable poly(phosphazene) nanoparticles surface modified with poly(phosphazene)-poly(ethylene oxide) copolymer
Authors: J. Vandorpe, E. Schacht, S. Dunn, A. Hawley, S. Stolnik, S.S. Davis, M.C. Garnett, M.C. Davies, L. Illum
Journal: Biomaterials (1997)
Polymorphisms in the IL4 , IL4RA , and FCERIB genes and asthma severity
Authors: Andrew J. Sandford, Tabassum Chagani, Shoukang Zhu, Tracey D. Weir, Tony R. Bai, John J. Spinelli, J.Mark FitzGerald, Nasser A. Behbehani, Wan C. Tan, Peter D. Paré
Journal: Journal of Allergy and Clinical Immunology (2000)
Toxic Psychosis Following Atropine Eye-drops
Authors: J. P. Baker, J. D. Farley
Journal: BMJ (1958)

UT 3. No abnormality found on clinical and haematological ex- amination.Osmotic fragility of red cells within normal limits.Foetal haemoglobin 2% of total.4. No abnormality on clinical and haematological examination.Osmotic fragility of red cells was within normal limits.Foetal haemoglobin less than 2% of total.5. Case 1, described.6 and 7.No haemoglobin-H found on paper electrophoresis.Foetal haemoglobin less than 2% of total.Paper electrophoresis did not show any increase of HbA2 in any of the relatives of Case 1.The Family of Case 2 1. Paper electrophoresis showed no haemoglobin-H.Haemo- globin 8.9 g./100 ml.This anaemia responded to the administra- tion of iron, her haemoglobin rising to 12 g./100ml.Foetal haemoglobin 2% of total.2.Not examined. 3. Electrophoresis showed haemoglobins A and H.She was suffering from a mild anaemia, similar to Case 2; haemoglobin 10.4 g./ 100 ml.Occasional target cells seen in blood film.Foetal haemoglobin less than 2% of total.4. Case 2, described.5.Not examined.6. Paper electrophoresis showed no haemoglobin-H.Foetal haemoglobin less than 2% of total.7. Paper electrophoresis showed no haernoglobin-H.Foetal haemoglobin 5% of total. (Child aged 1i years; haemoglobin 13 g./
Clinical Evaluation of a New Intravenous Gamma Globulin.
Authors: Edward Shanbrom
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Clinical Evaluation of a New Intravenous Gamma Globulin.Edward Shanbrom, M.D., F.A.C.P., Martha Hainski, Ph.D., John Payne, B.A.Edward Shanbrom, M.D., F.A.C.P.Search for more papers by this author, Martha Hainski, Ph.D.Search for more papers by this author, John Payne, B.A.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-812_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptExisting intramuscular gamma globulin preparations cannot provide immediate replacement therapy by infusion of large doses. Previous attempts to produce an intravenous gamma globulin by acid treatment or enzyme hydrolysis have resulted in preparations containing undesirable fragmented or aggregated molecules. The newly developed intravenous gamma globulin is a 3% protein concentration that is free of aggregates or anticomplementary activity. Clinical trials were conducted on 21 patients with acquired hypogammaglobulinemia secondary to lymphoma or leukemia. Four other patients with congenital hypogammaglobulinemia received single monthly injections to maintain "normal" gamma globulin levels. Severe infections were complications in the majority of patients. Doses of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, Calif. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByUndegraded γ-Globulin for Intravenous Therapy 1 May 1970Volume 72, Issue 5Page: 812-812KeywordsAttentionClinical trialsEnzymesGlobulinsLymphocytic leukemiaLymphomaProteins Issue Published: 1 May 1970 PDF DownloadLoading ...
Stroke Risk Following Perioperative Atrial Fibrillation
Authors: Pierluigi Tricoci
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inherited Breast and Ovarian Cancer
Authors: Mary-Claire King
Journal: JAMA (1993)

IT IS now clear that susceptibility to breast and ovarian cancer is inherited in some families. Between 5% and 10% of breast cancer<sup>1,2</sup>and ovarian cancer<sup>3</sup>can be attributed to inheritance of a gene conferring high risk, followed by genetic changes specific to the target epithelial cells of the breast or ovary. For decades, there has been no doubt that cancer is genetic, in the sense that transformation of a normal cell to invasive and malignant growth is due to changes in the DNA. But most cancer is genetic only at the level of the transformed cell, not in the germline cells of patients. Consequently, most cancer is not inherited in families. Not all that is genetic is inherited. Meanwhile, it has been observed for centuries that breast cancer clusters in families.<sup>4</sup>Of course, given the very high incidence of breast cancer in our times, there are
Facilitation of Cervical Dilatation by Intracervical Application of Sulprostone Gel prior to Hysteroscopy
Authors: W. Rath, W. Kuhn, R. Hilgers
Journal: Endoscopy (1985)

In a prospective, randomized study, 10 patients with primary sterility received an intracervical application of 0.1 mg Sulprostone-Tylose gel for cervical priming 12 hours prior to panoramic CO2-hysteroscopy and pelviscopy with chromopertubation. Ten patients who served as controls were not treated with the local prostaglandin. The force required to overcome the cervical canal was measured with a special tonometer for Hegar 3 before application of the gel in the group treated with Sulprostone and was 3-8 mm in both groups of patients immediately preoperatively. Cervical priming led to a significant reduction in the force required to dilate the cervix. After priming with Sulprostone, the cervical canal was freely passable for an average of 6.7 mm. In none of these patients was a force of 7 Newton exceeded for Hegar 8, whereas in the control group a mean force of 8.2 Newton was required to dilate the cervix for Hegar 6. Haemorrhage and epithelial lesions of the cervix caused by the dilatation can largely be avoided, and the risk of uterine damage reduced by local priming of the cervix. The intracervical application of prostaglandin gel is an easy, efficient and gentle method of dilatation for hysteroscopy, particularly in patients with a firmly closed and rigid cervix.
'I Am Doing Pretty Well. Thank You for Asking.'
Authors: Helmuth Goepfert
Journal: JAMA (1984)

At the age of 32 years, she had borne five children and had undergone a hysterectomy. Two years later, because of nephrolithiasis and irreversible chronic inflammation, one kidney was removed. She felt chronically tired and had intermittent edema of her face and extremities of undetermined cause. At the age of 37 years, she was referred for us to treat a cancer of the mouth with metastases to lymph nodes in the neck. The then-customary treatment was given, consisting of six weeks of radiation therapy to the mouth and neck, followed by a resection of the floor of the mouth, a radical neck dissection, and a temporary tracheostomy. During the next five years, she traveled the long distance to this hospital for five operations. On two occasions, portions of osteoradionecrotic mandible were removed, and three further ablations for recurrent cancer were undertaken. By this time she had lost all of her
Low paid workers are not paid enough to live healthily, Marmot says
Authors: I. Torjesen
Journal: BMJ (2014)

There are now more working households living in poverty than households where all of the adults are unemployed, because people with the lowest paid jobs are not being paid enough, said Michael Marmot, who led a government commissioned review into tackling health inequalities.1

Marmot, director of the Institute of Health Equity at University College London, noted that although five of the six policy actions that the Marmot review had concluded were needed to tackle health inequalities had appeared in the government’s public health white paper, they did not include the requirement for a minimum income for healthy living.2

Speaking at a Westminster Social Policy Forum seminar on 3 March he presented a graph showing that, although poverty in workless households had gone down, it had increased in working households.

“By 2011-2012 more working households are living in poverty than workless households and in …
SYPHILIS OF THE HEART
Authors: I. Harris
Journal: BMJ (1928)

BuIsU" NtvlVT 99129MMUCAx JOuWWAS ur-eters.The kidnevs showed extensive initerstitial fibrosis with tubu-lar changes superimposed.In both these cases ureteric obstrutction anid sutbsequent bacterial invasion of the organs are sufficient to account for the microscopic lesions.No case of typical chronic lead poisoniing occurred- constipatioln, co'lic, peripheral neuritis, encephalopathy, were never seen--hut one patient presenited a blue lead line on the gumis after 0.25 gram of lead given during a period of eleven weeks.Autopsies we-re made on 17 of those who died, and the posi-mnertem'tfindings were remarkably constant.In no'c&se was any sign of regression observed in the growth.Insomie cases it showved advanced degeneration (but no centr-al Table showving the Results int 56 Cases pf Malignzant Disease treated by Goil dfl Lead.Duration of Total Patient.Disease.Tramn.Ds.Results.
Subjects or Objects? Prisoners and Human Experimentation
Authors: Barron H. Lerner
Journal: New England Journal of Medicine (2007)

During the 1950s, inmates at what was then called Holmesburg Prison, in Philadelphia, were inoculated with condyloma acuminatum, cutaneous moniliasis, and viruses causing warts, herpes simplex, and herpes zoster.1 For participating in this research, and in studies exposing them to dioxin and agents of chemical warfare, they were paid up to $1,500 a month. Between 1963 and 1971, researchers in Oregon and Washington irradiated and repeatedly took biopsy specimens from the testicles of healthy prisoners; the men subsequently reported rashes, peeling, and blisters on the scrotum as well as sexual difficulties.2 Hundreds of such experiments induced the federal government to . . .
Association of EGF receptor expression with proliferating cells and of ras p21 expression with differentiating cells in various skin tumours
Authors: A. KIKUCHI, M. AMAGAI, K. HAYAKAWA, M. UEDA, S. HIROHASHI, N. SHIMIZU, T. NISHIKAWA
Journal: British Journal of Dermatology (1990)

The localization of DNA replicating cells, epidermal growth factor (EGF) receptor-expressing cells and ras oncogene product p21 (p-21ras) positive cells were examined in various skin tumours to elucidate the role of EGF receptor and p21ras in the epidermis. Normal skin, keratoacanthoma (KA), solar keratosis (SK), Bowen's disease (BD), squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and extramammary Paget's disease (PD) were studied. EGF receptors were seen in proliferating layers, where DNA replicating cells localize, but p21ras was found in the more differentiated layers. We conclude that EGF receptor expression is closely associated with cellular proliferation, but p21ras may play a role in the differentiation of cells in various skin tumours.
Consensus statement on iron overload in myelodysplastic syndromes
Authors: John M. Bennett
Journal: American Journal of Hematology (2008)

In May 2005 at the 8th International Symposium on Myelodysplastic Syndromes (MDS), a consensus meeting was held on iron overload in MDS (Seymour, Hematol Oncol Clin 2005; Suppl 1:18-25). The recommendations of the 2005 consensus meeting were discussed in the context of currently available evidence at the 9th International Symposium on Myelodysplastic Syndromes in Florence Italy, May 2007. The recommendations of the consensus working group are presented here. The recommendations are a continued refinement of the outcome of the 2005 consensus meeting and the ground-breaking work of others in this area (Seymour, Hematol Oncol Clin 2005; Suppl 1:18-25; Gattermann, Int J Hematol 2008;88:24-29; Alessandrino et al., Haematologica 2002;87:1286-1306; NCCN practice guidelines: Myelodysplastic Syndromes, version 2.2008).
Reviews, Notes, and Listings: Nephrology: UpToDate in Nephrology &amp;amp; Hypertension
Authors: Gail Morrison
Journal: Annals of Internal Medicine (1993)

Literature of Medicine1 November 1993Reviews, Notes, and Listings: Nephrology: UpToDate in Nephrology & HypertensionGail Morrison, MDGail Morrison, MDUniversity of Pennsylvania, Philadelphia, PA 19104.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-9-199311010-00051 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail UpToDate in Nephrology & HypertensionBurton D. Rose; ed. P.O. Box 812098, Wellesley, MA 02181-0013. Single user, $495.00; Partner of single user, $395.00; Fellow user, $135.00; Institutional user, $1000.00.In this era of information overload, one of the difficulties facing busy clinicians is how to keep current with the most recent and authoritative information in treating patients. Textbooks are quickly outdated, journals have proliferated during the last 10 years, and a library search is both time consuming and expensive. It is tempting to believe that a mechanism assimilating updated textbooks, recent journals, and a library search exists to access information on clinical ... Author, Article, and Disclosure InformationAffiliations: University of Pennsylvania, Philadelphia, PA 19104. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1993Volume 119, Issue 9Page: 960-961KeywordsDrugsHypertensionLibrariesMedical dialysisNephrologyPharmacokineticsRenal diseasesRenal transplantationSaltsSoftware tools ePublished: 15 August 2000 Issue Published: 1 November 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...