Norfloxacin and Seizures
Authors: Geraldine D. Anastasio
Journal: Annals of Internal Medicine (1988)

Letters and Corrections15 July 1988Norfloxacin and SeizuresGeraldine D. Anastasio, PharmD, Darlyne Menscer, MD, John M. Little Jr., MDGeraldine D. Anastasio, PharmDSearch for more papers by this author, Darlyne Menscer, MDSearch for more papers by this author, John M. Little Jr., MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-2-169 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Wolfson and Hooper (1) reported that four patients had seizures while receiving norfloxacin treatment. Additionally, another medication in this class, enoxacin, has also been associated with seizures (2). In written communication from the Food and Drug Administration's Adverse Drug Experience Monitoring Program, five cases of seizures associated with norfloxacin were reported. We report a case of new-onset seizure in a woman who was receiving norfloxacin treatment.A 61-year-old white woman who resides in a rest home had an observed, brief, generalized tonic-clonic seizure after receiving six days of norfloxacin treatment, 400 mg twice daily, for aPseudomonas...References1. WolfsonHooper JD. Norfloxacin: a new target fluoroquinolone antimicrobial agent. Ann Intern Med. 1988;108:238-51. LinkGoogle Scholar2. SimpsonBrodie KM. Convulsions related to enoxacin. Lancet. 1985;2:161. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Family Practice Residency Program Area Health Education Center Charlotte Memorial Hospital and Medical Center Charlotte, NC 28232-2861 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDetection of Signals of Convulsion-inducing Effect for Fluoroquinolone Antibiotics Alone and with Co-administration of Nonsteroidal Anti-inflammatory Drugs in Association with Aging Using Japanese Adverse Drug Event Reporting DatabaseQuinolonesQuinolonesEffect of Enoxacin, Felbinac, and Sparfloxacin on Fatty Acid Metabolism and Glucose Concentrations in Rat TissuesEffect of Fenbufen on the Entry of New Quinolones, Norfloxacin and Ofloxacin, into the Central Nervous System in RatsQuinolonesCiprofloxacinConvulsant activity of sitafloxacin and its interactions with anti-inflammatory drugs in miceA Seizure Attributed to Ofloxacine in a Woman Undergoing Detoxification for Alcohol DependenceAnxiogenic and proconvulsant effect of gatifloxacin in miceChanges in brain interleukin-1β following the coadministration of norfloxacin with biphenylacetic acid in ratsCelecoxib does not induce convulsions nor does it affect GABAA receptor binding activity in the presence of new quinolones in miceInhibition by fluoroquinolones of K+ currents in rat dissociated hippocampal neuronsEffects of anti-inflammatory drugs on convulsant activity of quinolones: a comparative study of drug interaction between quinolones and anti-inflammatory drugsConvulsant and Subconvulsant Doses of Norfloxacin in the Presence and Absence of Biphenylacetic Acid Alter Extracellular Hippocampal Glutamate but Not Gamma-Aminobutyric Acid Levels in Conscious RatsSeizures Associated with FluoroquinolonesBiphenylacetic acid enhances the antagonistic action of fluoroquinolones on the gabaA-mediated responses of the isolated guinea-pig ileumQuinolonesPharmacokinetic-pharmacodynamic modelling of the convulsant interaction between norfloxacin and biphenyl acetic acid in ratsEffects of Novel 6-Desfluoroquinolones and Classic Quinolones on Pentylenetetrazole-Induced Seizures in MicePharmacokinetic-Pharmacodynamic Contributions to the Convulsant Activity of Fluoroquinolones in RatsCharacterization of quinolone antibacterial-induced convulsions and increases in nuclear AP-1 DNA- and CRE-binding activities in mouse brainIn Vivo and In Vitro Toxicodynamic Analyses of New Quinolone-and Nonsteroidal Anti-Inflammatory Drug-Induced Effects on the Central Nervous SystemNeurotoxicodynamics of the Interaction between Ciprofloxacin and Foscarnet in MiceStudies on penetration of peroral new quinolone, levofloxacin to rabbit oral soft tissues with influence of stomachics sankyo magen mittelANTIBIOTIC-INDUCED CONVULSIONSSelective antagonism of the GABA A receptor by ciprofloxacin and biphenylacetic acidInhibitory Effect of New Quinolones on GABAAReceptor-Mediated Response and Its Potentiation with Felbinac inXenopusOocytes Injected with Mouse-Brain mRNA: Correlation with Convulsive Potencyin VivoCiprofloxacin–Phenytoin InteractionInhibition of GABA A Receptor Chloride Channel by Quinolones and Norfloxacin-Biphenylacetic Acid Hybrid CompoundsEvidence that a Hybrid Molecule of Norfloxacin and Biphenylacetic Acid is a Potent Antagonist at the GABA A ReceptorCiprofloxacin-induced acute psychosisAttenuated inhibition by levofloxacin, l-isomer of ofloxacin, on GABA response in the dissociated rat hippocampal neuronsEffets secondaires psychiatriques des fluoroquinolonesPossible intermolecular interaction between quinolones and biphenylacetic acid inhibits gamma-aminobutyric acid receptor sitesA Study on Gamma-Aminobutyric Acid (GABA) and Its Analogues by Using Molecular Orbital Methods: On Epileptogenicity of New QuinolonesInvolvement of inhibitory and excitatory neurotransmitters in levofloxacin- and ciprofloxacin-induced convulsions in miceEffects of ciprofloxacin and enrofloxacin on zoxazolamine kinetics, plasma concentration and sleeping times in miceEffects of fluoroquinolone antimicrobials alone and in conjunction with theophylline on seizures in amygdaloid kindled rats. 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