tbuckley/cabot-search huggingface dataset:
Tennis elbow in primary care
Authors: Nynke Smidt, Danielle AWM van der Windt
Journal: BMJ (2006)

Tennis elbow in primary careCorticosteroid injections provide only short term pain relief T ennis elbow or lateral humeral epicondylitis is considered to be an overload injury, which occurs after minor and often unrecognised trauma (microtrauma) to the proximal insertion of the extensor muscles of the forearm.The pathological changes often occur in the tendon of the extensor carpi radialis brevis muscle.The annual incidence of tennis elbow in general practice is four to seven cases per 1000 patients, with a peak in patients 35-54 years of age.Lateral epicondylitis is a self limiting condition.The average duration of a typical episode is about six months to two years, but most patients (89%) recover within one year. 1Various conservative interventions exist for the treatment of this condition including pain relieving drugs, corticosteroid injections, physiotherapy, elbow supports, acupuncture, surgery, and shockwave therapy.However, available evidence for the effectiveness of these interventions is limited. 2 In this week's BMJ a randomised controlled trial by Bisset and colleagues compares the effectiveness of physiotherapy, corticosteroid injections, and a "wait and see" policy in 198 people with tennis elbow. 3atients with symptoms lasting at least six weeks were recruited through advertisements and media releases in Brisbane, Australia.Interventions were physiotherapy consisting of eight sessions of mobilisation with movement and exercises; injection therapy, including at least one injection of 1 ml triamcinolone acetonide (10 mg) and 1 ml lidocaine 1%; or a wait and see policy consisting of ergonomic instructions and use of analgesic drugs, heat, cold, or braces, if needed.At six weeks' follow-up, the main outcome measures (global improvement, pain-free grip strength, assessor's rating of the severity of complaints, severity of elbow pain, and elbow disability) were significantly better in the group receiving corticosteroid injections than in the other groups.However, the benefits of corticosteroid injections lasted for a short time only.At long term follow-up, the opposite effects were found, with physiotherapy being superior to corticosteroid injections for all outcome measures.The wait and see policy also showed beneficial long term effects compared with corticosteroid injections, although these differences were not statistically significant for all outcomes.Physiotherapy showed superior short term effects compared with the wait and see policy, but in the long term, these differences were not statistically significant or clinically relevant. 3everity of pain during one year of follow-up in three randomised controlled trials Saturday
Manuscript cited in “Specific inhalation challenge in the diagnosis of occupational asthma: consensus statement”
Authors: Olivier Vandenplas, Hille Suojalehto
Journal: European Respiratory Journal (2014)

From the authors: 

On behalf of our Task Force, I would apologise for “inappropriately” referencing the quoted article co-authored by Jean-Luc Malo, which was published in his highly renowned textbook Asthma In the Workplace [1]. Actually, we referred …
Charity, the Media, and Limited Medical Resources
Authors: Eugene V. Boisaubin
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aversion Therapy by Electric Shock: a Simple Technique
Authors: R. J. McGuire, M. Vallance
Journal: BMJ (1964)

Aversion therapy has been used for many years in the treatment of alcoholism (3). Apomorphine and emetine are the usual drugs used as the unconditioned stimuli for nausea and vomiting, with alcohol as the conditioned stimulus. More recently the same procedure has been used in the treatment of sexual perversions—for example, fetishism (12), transvestism (1, 5) and homosexuality (11, 7).
TREATMENT OF PROGRESSIVE ATROPHY OF THE OPTIC NERVE DUE TO ACQUIRED SYPHILIS.BY SUBCONJUNCTIVAL AND INTRAVAGINAL INJECTIONS OF SUBLIMATE OF MERCURY.
Authors: CHARLES STEDMAN BULL
Journal: JAMA (1906)

The treatment of syphilitic atrophy of the optic nerve is a subject which taxes all our patience and ingenuity. So universally unfavorable is the prognosis that the ophthalmic surgeon is ready to grasp almost any means which promises a solution of the problem. All surgical interference with the optic nerve itself, such as incision of the nerve sheath in several places, or elongation of the nerve by stretching, has yielded such imperfect and inconstant results that it can not any longer be recommended and has been abandoned. The same may be said of sympathectomy, which has so recently been vaunted as a remedy for atrophy. The constant current, and even static electricity, have been faithfully tried and have usually proved unavailing. Much has been claimed for the treatment by vibratory massage, but I have never personally known of a case of atrophy which has been permanently, or even temporarily, benefited
How to Fix the Premedical Curriculum
Authors: Lewis Thomas
Journal: New England Journal of Medicine (1978)

THE influence of the modern medical school on liberal-arts education in this country over the last decade has been baleful and malign, nothing less. The admission policies of the medical schools are at the root of the trouble. If something is not done quickly to change these policies, all the joy of going to college will have been destroyed, not just for that growing majority of undergraduate students who draw breath only to become doctors, but for everyone else, all the students, and all the faculty as well.The medical schools used to say they wanted applicants as broadly educated . . .
Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR
Authors: Claudia L Kleinman, Noha Gerges, Simon Papillon-Cavanagh, Patrick Sin-Chan, Albena Pramatarova, Dong-Anh Khuong Quang, Véronique Adoue, Stephan Busche, Maxime Caron, Haig Djambazian, Amandine Bemmo, Adam M Fontebasso, Tara Spence, Jeremy Schwartzentruber, Steffen Albrecht, Peter Hauser, Miklos Garami, Almos Klekner, Laszlo Bognar, Jose-Luis Montes, Alfredo Staffa, Alexandre Montpetit, Pierre Berube, Magdalena Zakrzewska, Krzysztof Zakrzewski, Pawel P Liberski, Zhifeng Dong, Peter M Siegel, Thomas Duchaine, Christian Perotti, Adam Fleming, Damien Faury, Marc Remke, Marco Gallo, Peter Dirks, Michael D Taylor, Robert Sladek, Tomi Pastinen, Jennifer A Chan, Annie Huang, Jacek Majewski, Nada Jabado
Journal: Nature Genetics (2013)
Mirabel Project: Description of a French Population of 785 Peanut Allergic or Sensitized Patients
Authors: Anne D. Moneret-Vautrin, Antoine Deschildre, Jocelyne Just, Olivier Bruyère, Xavier van Der Brempt, Etienne Beaudouin, Fabrice Elegbede, Amelie Crepet
Journal: Journal of Allergy and Clinical Immunology (2015)
"METALS IN OUR FOOD"
Authors: Carey P. McCord
Journal: JAMA (1928)

<h3>To the Editor:</h3> —The article by Flinn and Inouye (The Journal, March 31, p. 1010) entitled "Metals in Our Food" is praiseworthy up to the point of apparently exculpating copper, zinc and aluminum as industrial poisons. I quote from the summary of the article (with one intervening paragraph omitted): Copper, zinc, aluminum and nickel are not classified as industrial poisons because of the absence of any evidence of chronic or acute poisoning in industrial plants. Nickel poisoning has been reported from nickel carbonyl. Tin apparently does not affect the human system, but because of its cost its use in cooking utensils is prohibitive. In the same mail that brought this article came a copy of a record of the compensable occupational diseases under the Industrial Commission of Ohio, for a two and one-half year period, ending Dec. 31, 1927. I note therein a mention of seventeen cases of systemic zinc
Lifelong checks are needed for patients fitted with dangerous hip implants
Authors: I. Torjesen
Journal: BMJ (2012)

Around 49 000 UK patients with metal-on-metal hip implants with a femoral diameter of 36 mm or more will need follow-up tests for the rest of their lives, the Medicines and Healthcare Products Regulatory Agency has announced in what could prove to be the biggest medical device dispute for years.

The agency issued a medical device alert on the hip implants at an emergency briefing yesterday, called to coincide with the release of the findings of an investigation by the BMJ and BBC Newsnight , which revealed problems with metal-on-metal implants caused by metal ions leaking into the body. 

Metal-on-metal implants, which have been used since the late 1990s, …
Pulmonary veno-occlusive disease in a unilateral hypertransradiant lung.
Authors: M Pajewski, R Reif, H Manor, R Starinsky, D Katzir
Journal: Thorax (1981)

Pulmonary veno-occlusive disease (VOD) is an extremely rare cause of pulmonary hypertension, leading ultimately to right heart failure and death.In the 30 or so cases published up to 1976, the veno-occlusive process affected both lungs.1Calderon and Burdine2 reported a case affected by VOD with asymmetrical disturbanceof perfusion caused by unilateral stenosis of major veins.The abnormalities of smaller veins and venules were, however, distributed in a similar fashion throughout both lungs.This communication deals with a patient in whom VOD was confined to a unilateral hypertransradiant lung (Swyer-James MacLeod syndrome).The patient although suffering from recurrent bouts of unilateral lung infection was free of symptoms referrable to pulmonary hypertension.To the best of our knowledge no instance of a unilateral hypertransradiant lung being the site of pul- monary veno-occlusive disease has been reported. Case repot t
Complacency in Anaesthetics?
Authors: H. Parry-Price
Journal: BMJ (1942)

Contractile responses to leukotriene (LT)C4, LTD4 and LTE4 were examined in intralobar airways from human lung obtained after surgical resection. In addition, the ability of the LT receptor antagonist FPL55712 to antagonize responses to LTC4 and LTD4 was quantified (by calculating -log molar KB values) under experimental conditions designed to minimize metabolic transformation of the LTs. In the absence of drug pretreatment, the three peptide LTs were approximately equipotent and produced similar maximum degrees of contraction. L-Serine borate complex, 45 mM, used as an inhibitor of the degradation of LTC4 to LTD4 by the enzyme gamma-glutamyl transpeptidase, in paired airway segments (adjacent segments from the same branch), produced a small degree (about 3-fold) of shift to the right of the dose-response curve and reduction of the maximum response to LTC4. L-Cysteine, 3 mM, used as an inhibitor of the degradation of LTD4 to LTE4 by the enzyme aminopeptidase, in paired segments, did not alter the dose-response effects of LTD4 or appear to further alter the dose-response effects of LTC4 when applied together with L-serine borate complex in unpaired (nonadjacent) segments. The -log molar KB value for FPL55712 (about 6) was similar for antagonism of responses to both LTC4 and LTD4 in the absence or presence of treatment with the metabolic inhibitors L-serine borate complex, L-cysteine or a combination of the two treatments. The results suggest that inhibition of the enzymes involved in the pathway from LTC4 to LTE4 has little consequence in human airways because the three peptide LTs are approximately equipotent.(ABSTRACT TRUNCATED AT 250 WORDS)
Correlations of Y chromosome microchimerism with disease activity in patients with SLE: analysis of preliminary data
Authors: M Mosca
Journal: Annals of the Rheumatic Diseases (2003)

Recently it has been suggested that microchimerism may have a significant role in the aetiopathogenesis of some autoimmune diseases.To evaluate the incidence of microchimerism in systemic lupus erythematosus (SLE), to quantify the phenomenon, to evaluate changes of microchimerism during follow up, and to correlate these data with clinical and laboratory variables.Patients were selected for the study on the basis of the following criteria: (a) pregnancy with at least one male offspring; (b) no history of abortion and blood transfusion. Microchimerism was detected using a competitive nested polymerase chain reaction for a specific Y chromosome sequence and an internal competitor designed ad hoc. Disease activity and organ involvement were also evaluated.Sixty samples from 22 patients with SLE and 24 healthy controls were examined. Microchimerism was seen in 11 (50%) patients and 12 (50%) controls. The mean number of male equivalent cells was 2.4 cells/100 000 (range 0.1-17) in patients with SLE and 2.5 (range 0.2-1.8) in healthy controls. No differences in the incidence of microchimerism or in the number of microchimeric cells were found between patients and healthy controls. Patients with a history of lupus nephritis had a higher mean number of fetal cells than patients with no such history. Disease activity did not appear to correlate with microchimerism.The preliminary data suggest that microchimerism does not interfere with the disease course of SLE, although further analysis on larger groups will be necessary to confirm these observations.
STANDARDIZATION OF DIGITALIS
Authors: C. W. Edmunds
Journal: JAMA (1934)

<h3>To the Editor:—</h3> I was much interested in the communication published inThe Journal, March 17, and purporting to come from the Heart Committee of the New York Tuberculosis and Health Association, although it is signed by the "Digitalis Committee." Whether these two committees are in reality two or whether they are one and the same under different names I am unable to say. Before discussing the contents of the communication I would point out that it should more properly have been addressed to Professor Cook, the chairman of the U. S. Pharmacopeial Revision Committee, which has the matter of biologic standardization of digitalis and other drugs in charge, and it would doubtless have been referred to the proper subcommittee, where I am sure it would have received careful and sympathetic consideration. However, I am tempted to consider some of the points raised by it, as they have been for
Abstract C25: A five-gene signature is associated with tumor progression and poor prognosis in colorectal cancer
Authors: Jummei Hao, Guangqiu Li, Hongmei Sui, Xueqing Si-Ma, Chao Liu, Yanqing Ding, Jianming Li
Journal: Cancer Research (2009)

Abstract In order to develop an experimentally derived molecular signature closely associated with survival of colorectal cancer (CRC) patients from mouse tumor models, we isolated single cell-derived progenies (SCPs) from SW480 CRC cell line and compared their metastatic potential in an orthotopic implantation model of murine CRC. We compared the differences in the gene expression profiles of a high metastatic variant SCP51, a low metastatic variant SCP58 and their parent SW480/EGFP. We found that 143 genes were commonly differentially expressed between SCP51 and SCP58 cells, SCP58 and SW480/EGFP. Using Gene-annotation enrichment analysis of DAVID, 80 genes were found in top ten clusters of the analysis. Thirty-two genes of above the 80-gene set were found to be involved in metastasis by Genclip, a text mining program. We selected five genes (LYN, SDCBP, MAP4K4, DKK1 and MID1) for immunohistochemical analysis in a cohort of 181 CRC patients. Results showed those LYN, SDCBP, MAP4K4, MID1 and five-gene signatures were significantly correlated with overall survival in patients with CRC. We also found that LYN, MAP4K4 and MID1 but not SDCBP and DKK1 expression was closely correlated with lymph node metastasis and Dukes classification in patients with CRC. Our five-gene signature was closerly associated with survival of CRC patients and could be used as a potential prognostic factor for CRC. Citation Information: Cancer Res 2009;69(23 Suppl):C25.
Differential Diagnosis: Distinguishing Between Ghostwriting and Professional Medical Writing in Biomedical Journals
Authors: Cindy W. Hamilton
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
MANUAL ON ALCOHOLISM
Authors: Dale C. Cameron
Journal: JAMA (1967)

Publication of the new AMA<i>Manual on Alcoholism</i>comes at a time when jurists and legislators are expressing as public policy what most physicians have long known but few have acted upon: that alcoholism in itself is not a crime, nor a reflection of moral turpitude, nor the mark of the shiftless and the profligate, but an<i>illness</i>—a chronic disorder with physical, psychological, and sociological causes, symptoms, and complications. The<i>Manual</i>, which in 100 pages presents material on etiology and diagnosis and on treatment and rehabilitation methods, defines alcoholism as an illness characterized by preoccupation with alcohol and loss of control over its consumption such as to lead usually to intoxication if drinking is begun; by chronicity; by progression; and by tendency toward relapse. Typically, the<i>Manual</i>points out, alcoholism is associated with physical disability and also with impaired emotional, occupational, and/or social adjustments as a direct consequence of
Under‐report and underdiagnosis of chronic respiratory diseases in an African country
Authors: P. Martins, J. Rosado‐Pinto, M. Do Céu Teixeira, N. Neuparth, O. Silva, H. Tavares, J. L. Spencer, D. Mascarenhas, A. L. Papoila, N. Khaltaev, I. Annesi‐Maesano
Journal: Allergy (2009)

Background: Chronic respiratory diseases (CRD) are greatly underestimated. The aim of this study was to assess the burden associated with reported CRD and chronic obstructive pulmonary disease, as defined on the basis of various standardized criteria, by estimating their point prevalence in a sample of individuals attending the Primary Health Care (PHC) level and Emergency Room (ER) Departments in Cape Verde (CV) archipelago. The second aim of the study was to identify factors related to airways obstruction and reported CRD in this population. Methods: A cross‐sectional study was carried out in CV during 2 weeks. Outpatients aged more than 20 years seeking care at PHC level and ER answered a standardized questionnaire and were subjected to spirometry, independently of their complaint. Two criteria for airways obstruction were taken into account: forced expiratory volume (FEV 1 ) &lt;80% of the predicted value and FEV 1 /forced vital capacity (FVC) ratio &lt;0.70. Results: A total of 274 individuals with a satisfactory spirometry were included. 22% of the individuals had a FEV 1 &lt; 80%. Individuals older than 46 years had a higher risk of having airways obstruction. Asthma diagnosis (11%) had a clear association with airways obstruction. Smoking was a risk factor for a lower FEV 1 . Working in a dust place and cooking using an open fire were both related to chronic bronchitis and asthma diagnosis. Conclusion: Under‐report and underdiagnosis of chronic respiratory conditions seem to be a reality in CV just as in other parts of the world. To improve diagnosis, our results reinforce the need of performing a spirometry.
Cancer Statistics, 2005
Authors: A. Jemal, T. Murray, E. Ward, A. Samuels, R. C. Tiwari, A. Ghafoor, E. J. Feuer, M. J. Thun
Journal: CA A Cancer Journal for Clinicians (2005)

Each year, the American Cancer Society estimates the number of new cancer cases and deaths expected in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival based on incidence data from the National Cancer Institute and mortality data from the National Center for Health Statistics. Incidence and death rates are age-standardized to the 2000 US standard million population. A total of 1,372,910 new cancer cases and 570,280 deaths are expected in the United States in 2005. When deaths are aggregated by age, cancer has surpassed heart disease as the leading cause of death for persons younger than 85 since 1999. When adjusted to delayed reporting, cancer incidence rates stabilized in men from 1995 through 2001 but continued to increase by 0.3% per year from 1987 through 2001 in women. The death rate from all cancers combined has decreased by 1.5% per year since 1993 among men and by 0.8% per year since 1992 among women. The mortality rate has also continued to decrease from the three most common cancer sites in men (lung and bronchus, colon and rectum, and prostate) and from breast and colorectal cancers in women. Lung cancer mortality among women has leveled off after increasing for many decades. In analyses by race and ethnicity, African American men and women have 40% and 20% higher death rates from all cancers combined than White men and women, respectively. Cancer incidence and death rates are lower in other racial and ethnic groups than in Whites and African Americans for all sites combined and for the four major cancer sites. However, these groups generally have higher rates for stomach, liver, and cervical cancers than Whites. Furthermore, minority populations are more likely to be diagnosed with advanced stage disease than are Whites. Progress in reducing the burden of suffering and death from cancer can be accelerated by applying existing cancer control knowledge across all segments of the population.