tbuckley/cabot-search huggingface dataset:
A comparison of systolic time intervals derived from the central aortic pressure and from the external carotid pulse tracing.
Authors: F Van de Werf, J Piessens, H Kesteloot, H De Geest
Journal: Circulation (1975)

In 26 patients a direct comparison was made of systolic time intervals derived from the right and left external carotid pulse tracing and from the central aortic pressure, simultaneously recorded by means of a catheter-tip micromanometer. In addition, the delay time (required for pulse wave transmission to the neck) of the upstroke (DUEC) and incisura (DIEC) of the external carotid pulse tracing was studied. The influence of changes in heart rate on these intervals was evaluated by right atrial pacing. At resting frequencies DUEC exceeded DIEC by 4 to 4.5 msec (P less than 0.005). Increasing heart rate did not influence DUEC but prolonged DIEC. Differences between DUEC and DIEC were associated with a decrease and reversal with increasing heart rate (tau = 0.52, on the right carotid pulse; tau = 0.65, on the left pulse). Internally and externally measured left ventricular ejection time and pre-jection period were strongly correleated. Significant differences in absolute values were also observed. Whether these differences were positive or negative was dependent on heart rate. At rest external left ventricular ejection time was 4 to 4.5 msec (P less than 0.005) shorter, external pre-ejection period 5.5 to 6 msec (P less than 0.005) longer than corresponding intervals measured internally. At heart rates above plus or minus 100 beats/min the relationships were reversed. No significant differences could be demonstrated between these intervals measured on the right and left external carotid pulse.
Endoscopic Laser Lithotripsy with an Automatic Stone Recognition System for Basket Impaction in the Common Bile Duct
Authors: H. Neuhaus, W. Hoffmann, M. Classen
Journal: Endoscopy (1992)

In a patient with a common bile duct stone 28 mm in diameter, the traction wires of two basket catheters fractured during endoscopic mechanical lithotripsy. Disintegration of the concrement and removal of the impacted baskets failed even after extracorporeal application of 8,000 shockwaves. Pulsed dye laser lithotripsy was carried out via a 250 microns fiber which was advanced to the stone through a 6 French ERCP guiding catheter. Lithotripsy could be safely performed under fluoroscopic control since the laser used provides an automatic cut-out system upon tissue contact. 3,600 of 11,800 applied pulses were emitted with the total power setting and complete disintegration of the calculus was achieved. The baskets and the fragments could be removed endoscopically in the same session. Laser lithotripsy with a stone recognition system would seem to improve the applicability and safety of intracorporeal lithotripsy even when performed without direct visual guidance.
How many doctors does Britain need?
Authors: J Fry
Journal: BMJ (1993)

Unlicensed nicotine skin patches EDITOR,-Nicotine skin patches were launched in Britain in June 1992.Three licensed patches (Nicabate, Nicorette, Nicotinell) are now available over the counter from pharmacies.There is convincing evidence from clinical trials that these patches are an effective aid to stopping smoking.'In the past two months there has been a rash of newspaper advertisements for unlicensed patches available by mail order.We are aware of brands going under the names Nicostop, Nicorene, Nicotine Patch, Nicocheck, and Nicoban.The advertisements for two brands, for example, make extravagant claims: "Guaranteed to stop you smoking" (Nicostop); "With Nicoban's help you stop smoking painlessly, simply, permanently....You wear it on your arm, and it releases a measured dosage of nicotine extract throughout the day which really does take away the desire to smoke.So simple, so easy.And above all ... so effective."Common to these patches is the claim that they deliver either nicotine or "nicotine extract" and the promise of great savings over patch products "sold by our competitors."But none of these mail order products has undergone regulatory scrutiny.We
Antinuclear Factor, a Dysimmunological Feature in Mental Depression. A Preliminary Communication
Authors: R.D. Deberdt, J. van Hooren, W. Amery
Journal: Psychotherapy and Psychosomatics (1974)

Antinuclear factor was present in the serum of more than one-fourth of 32 patients admitted to the psychiatric hospital because of mental depression. It appears that a positive antinuclear factor may be a rather common finding in endogenous depressions and the present data suggest that the presence of this serum factor is of unfavourable prognostic significance.
Smoking habits of long-term survivors of surgery for lung cancer.
Authors: A G Davison, M Duffy
Journal: Thorax (1982)

The smoking habits of 52 patients who had survived more than five years after treatment for lung cancer were studied. Fifty-six per cent had stopped smoking before operation but this was not an early feature of the disease. No patients smoked in the immediate postoperative period but 48% became regular smokers again, usually within a year of the operation. Those who had stopped before, rather than after, their operation were more likely to remain nonsmokers. Doctors were usually unsuccessful in persuading those patients who had restarted after surgery to stop smoking. Patients undergoing surgery for lung cancer should be advised to stop smoking before the operation. Those in whom resection is successful should receive regular support and encouragement from doctors, especially in the first postoperative year, to continue as nonsmokers.
Pulmonary and gastrointestinal exposure to cadmium oxide dust in a battery factory.
Authors: E Adamsson, M Piscator, K Nogawa
Journal: Environmental Health Perspectives (1979)

The elimination of cadmium in feces was studied in a group of 15 male workers exposed to cadmium oxide dust in a nickel-cadmium battery factory. The elimination of cadmium in feces was on the average 619 and 268 microgram/day in seven smokers and eight nonsmokers, respectively. The corresponding ranges were 97-2577 and 31-1102 microgram/day. The cadmium concentrations in blood were significantly higher in smokers than in nonsmokers, both before and after one month of vacation. Among the smokers there was a significant decrease in the cadmium concentrations during the vacation period, but not among the nonsmokers. It was estimated that cadmium naturally occurring in food and cigarettes, cadmium excreted from the gastrointestinal tract, and cadmium transported from the lungs by mucocillary clearance to the gastrointestinal tract only could explain up to 100 microgram of the cadmium in the feces. Since even among some nonsmokers much higher values for fecal cadmium were recorded, this was interpreted as being the result of ingestion of cadmium from contaminated hands and other body surfaces. Among the smokers, direct oral contact with contaminated cigarettes or pipes is an additional factor; the smokers also inhale cadmium in the tobacco smoke from contaminated cigarettes. Part of that cadmium is transferred to the gastrointestinal tract by mucociliary clearance and also adds to the fecal cadmium.
ADAMTS‐13 activity can predict the outcome of disseminated intravascular coagulation in hematologic malignancies treated with recombinant human soluble thrombomodulin
Authors: Muneo Ohshiro, Junya Kuroda, Yutaka Kobayashi, Teruaki Akaogi, Eri Kawata, Nobuhiko Uoshima, Yuri Kamitsuji, Hiroto Kaneko, Kazuho Shimura, Chihiro Shimazaki, Satoshi Murakami, Mayumi Hatsuse, Akira Okano, Tsutomu Kobayashi, Hitoji Uchiyama, Yosuke Matsumoto, Shigeo Horiike, Masafumi Taniwaki
Journal: American Journal of Hematology (2011)

Abstract We conducted a multicenter prospective study for evaluating the utility and prognostic markers of recombinant human soluble thrombomodulin (rTM) treatment for acute disseminated intravascular coagulation (DIC) by various types of hematologic malignancies. The study comprised 30 patients with DIC due to hematologic diseases without severe infection. DIC improved in 15 patients and 20 were alive on day 28. Univariate analyses showed that, in comparison with patients who had survived on day 28, patients who had not survived on day 28 showed significantly higher plasma levels of plasminogen activator inhibitor‐I (PAI‐I) and significantly lower plasma activity of a disintegrin and metalloproteinase with a thrombospondin Type 1 motif, member 13 (ADAMTS‐13). Moreover, multivariate logistic regression analysis identified a significant association between plasma ADAMTS‐13 activity before treatment and survival on day 28 ( P = 0.034). In particular, patients with lower ADAMTS‐13 activity (≤65%) had a poorer survival rate than those with a higher activity ( P = 0.042). These findings suggest that the plasma ADAMTS‐13 activity at the time of DIC diagnosis might help to predict the prognosis of patients treated with rTM for DIC associated with hematologic malignancies. Am. J. Hematol., 2012. © 2011 Wiley‐Liss, Inc.
Gene mutation may increase risk of breast cancer by up to nine times
Authors: M. McCarthy
Journal: BMJ (2014)

A mutation in a gene that plays a key role in the proper functioning of the so called “breast cancer genes” BRCA1 and BRCA2 increases the risk of developing breast cancer by nine times in younger women and by five times in older women, a new study has found.1

In the study, researchers analysed the risk of breast cancer in women and men from families who had germline loss-of-function mutations in a gene called PALB2 (partner and localiser of BRCA2). Loss-of-function mutations in both alleles of PALB2—which is also known as FANCN—cause Fanconi’s anaemia, …
202. Effect of Modification with Lipophilic Fragments and Inclusion of Endosomolytic Peptide on Transfection Efficiency Mediated by Lysine Dendrimers
Authors: Anna A. Egorova, Polina L. Il'ina, Anton V. Kiselev, Aleksandre N. Baranov, Irina I. Tarasenko, Gennadii P. Vlasov, Vladislav S. Baranov
Journal: Molecular Therapy (2006)

Development of effective non-viral DNA carriers is considered to be a perspective approach for DNA delivery into eucaryotic cells with gene therapy aims. Our research was devoted to group of asymmetric lysine dendrimers. We studied fifth generation dendrimer D5 and its analog D5C10 which was modified by capric acid residues in external sphere. All vehicles were investigated for their capacity to bind DNA (using gel-retardation and ethidium bromide exclusion assay) and to provide protection plasmid DNA from nuclease degradation (using DNAse I protection test). Transfectional capacity of dendrimers were tested according to the efficiency of beta- galactosidase gene expression in HeLa cells. Modification of dendrimers by capric residues resulted in increase of ability to bind and to protect DNA from enzymatic degradation. Besides, D5C10 provides 10-fold more effective DNA delivery into cells, compared to D5. Addition of endosomolytic peptide JTS-1 to DNA/dendrimer complexes resulted in significant increase of gene delivery with dendrimers, especially with D5C10. The transfection effectiveness for DNA/D5C10/JTS-1 reached 16%. Thus we demonstrate that D5 and D5C10 carriers are perspective vehicles for DNA delivery into cells and can be basis for the development of more effective modular non-viral systems.
Chlamydial respiratory infections: Don't get bogged down by differentiating species: Author's reply
Authors: S J Bourke
Journal: BMJ (1993)

explains the increased sensitivity of whole cell inclusion immunofluorescence, which detects genus specific and species specific antibody.3Antigenic diversity within species has also led to a serious failure of microimmunofluorescence to detect many C psittaci infections.The specificity of microimmunofluorescence has been questioned owing to reports of cross reactivity between species4 and the demonstration of both species specific and genus specific epitopes being expressed on elementary bodies.Serological approaches are used variably by some clinicians investigating respiratory infections, highlighting the need for non-invasive diagnostic alternatives.The value of routinely used com- mercial enzyme linked immunoassays to detect chiamydia in sputum has been shown in laboratory diagnosis provided that reactive samples are confirmed with direct immunofluorescence.5Genome detection of chlamydia in sputum, although promising, is currently unsuitable for hospital laboratories.Undoubtedly, future techniques will focus on molecular approaches.It would be foolhardy to be overwhelmed by the hyperbole surrounding C pneumoniae and to ignore, within our current knowledge, the clinically more important respiratory pathogen-Cpsittaci.
A conversation with Aaron Ciechanover
Authors: Ushma S. Neill
Journal: Journal of Clinical Investigation (2013)

For decades, the attention of the scientific community was focused on the central dogma of biology — the decoding of the genetic information embedded in DNA. Little research was dedicated to how proteins are degraded and removed from cells. Enter onto the scene a young graduate student, Aaron Ciechanover, who with his mentor Avram Hershko, uncovered the complex and elegant ubiquitin proteolytic system. For his discovery, Ciechanover (Figure ​(Figure1)1) shared in the 2004 Nobel Prize in Chemistry with Hershko and Irwin Rose. The complete interview, with more stories about being a member of the Pontifical Academy of Sciences, the magic of “A-ha” moments, and the conflict between religion and Darwinism, can be seen on the JCI website, http://www.jci.org/kiosk/cgm.
After Quinlan: The Dilemma of the Persistent Vegetative State
Authors: Marcia Angell
Journal: New England Journal of Medicine (1994)

In 1968 an ad hoc committee of Harvard Medical School recommended that death be defined as cessation of all brain function1. Before that time, a patient was not pronounced dead until heart and lung function had ceased. One by one, the states accepted brain death as the legal definition of death -- a movement that was accelerated when the President's Commission formulated the Uniform Determination of Death Act in 19812. All 50 states and the District of Columbia now accept this standard3. It is remarkable how rapidly the concept of brain death attracted an ethical, social, and . . .
Multiple Progressive Calcific Pleural Plaque Formation
Authors: Louis Schneider, Felix Wimpfheimer
Journal: JAMA (1964)

RECENTLY WE OBSERVED a peculiar type of slowly progressive, multiple calcific pleural plaque formation in three elderly men. They had been referred to us with a diagnosis of pulmonary tuberculosis; two of them had been treated for this disease. A review of the relevant literature, stimulated by the bizarre and puzzling roentgenographic appearance of these men's chests, however, indicated to us that inhalation of silicates—such as asbestos or related minerals would be a more likely cause for these lesions. Indeed, further inquiry into the patients' backgrounds uncovered exposure to asbestos in two of them. The infrequent and at best cursory mention of this condition with its striking x-ray manifestations in the important American works on chest disease and radiology has led us to communicate this experience and to review the relevant information in the literature. <h3>Report of Cases</h3><h3>Case 1.</h3> -A Negro male was 55 years old in 1954 when
Is factuality a matter of content?
Authors: Gregory Currie
Journal: Behavioral and Brain Sciences (1999)

Dienes &amp; Perner argue that there is a hierarchy of forms of implicit knowledge. One level of their hierarchy involves factuality, where it may be merely implicit that the state of affairs is supposed to be a real one rather than something imagined or fictional. I argue that the factual or fictional status of a thought or utterance cannot be a matter of concept, implicit or explicit.
Reviews, Notes, and Listings: Practical Strategies in Outpatient Medicine
Authors: Joel Betesh
Journal: Annals of Internal Medicine (1993)

Literature of Medicine1 October 1993Reviews, Notes, and Listings: Practical Strategies in Outpatient MedicineJoel Betesh, MDJoel Betesh, MDHahnemann University, Philadelphia, PA 19102Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-7_Part_1-199310010-00037 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Practical Strategies in Outpatient MedicineSecond edition. Brendan M. Reilly; ed. 1320 pages. Philadelphia: W.B. Saunders; 1991. $120.00.Internal medicine training is shifting its emphasis toward more outpatient rotations at both the medical school and residency levels. With this shift comes a need for a textbook that will provide both the student and preceptor with a core knowledge base for ambulatory training. The second edition of Practical Strategies in Outpatient Medicine only partially meets this need.As a preceptor for a full-time outpatient ambulatory care course for senior medical students, I have felt the need for a text to correspond to the clinical ... Author, Article, and Disclosure InformationAffiliations: Hahnemann University, Philadelphia, PA 19102 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1993Volume 119, Issue 7_Part_1Page: 639-640KeywordsAnklesDementiaHypertensionLibrariesLiver diseasesOutpatientsPreventive medicineResidencyTraditional medicine ePublished: 15 August 2000 Issue Published: 1 October 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Neutrophil-derived long-lived oxidants in cystic fibrosis sputum.
Authors: V Witko-Sarsat, C Delacourt, D Rabier, J Bardet, A T Nguyen, B Descamps-Latscha
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

We evaluated long-lived oxidant potential in the sputum of patients with cystic fibrosis (CF) by quantitating the methionine-inhibitable, long-lived oxidant fraction of sputum, referred to as the chloramines. Taurine, the preferred amino acid substrate for chloramine formation, and myeloperoxidase (MPO), the chlorinated oxidant-generating enzyme, were also quantitated. As compared with the sputum of asthmatic subjects, the sputum of CF patients contained high concentrations of chloramines along with high levels of taurine and active MPO. A negative correlation between chloramine and taurine was found in the sputum of CF patients. No correlation was found between the density of Pseudomonas aeruginosa and the level of chloramines, taurine, or MPO. In contrast, respiratory parameters (%FEV or %FVC) and a nutritional index correlated positively with chloramine levels, whereas negative correlations were observed with taurine and MPO. In addition, the effect of antibiotic therapy, which significantly increased chloramine and decreased taurine levels, supported a beneficial effect of chloramines on overall clinical status. Our findings support a dual role of long-lived oxidants at the site of airway inflammation in CF, one component of which is their ability to mediate oxidative stress and the other a beneficial effect that may be partly explained by their inhibitory effect on antiprotease defense systems.
Newly diagnosed hypothyroidism
Authors: H U Rehman, T A Bajwa
Journal: BMJ (2004)

A 46 year old woman has returned to you for the results of blood tests.Two weeks earlier she had complained of increasing tiredness, constipation, dry skin, and weight gain.Thyroid function tests at her previous consultation showed concentrations of free thyroxine (T4) of 7 nmol/l and of thyroid stimulating hormone (TSH) of 38 mU/l.Her mother had Graves' disease and was treated with radioiodine ablation.
Short-term Service Abroad
Authors: D. Morley, G. J. Ebrahim, M. Woodland
Journal: BMJ (1973)

dentistry.Before the dentistry was begun she became unconscious, convulsed, and following resuscitative measures in the dental surgery, was admitted to hospital where, without regaining consciousness, she died some days later.Lum- bar puncture had revealed subarachnoid haem- orrhage and a postmortem examination confirmed the presence of a ruptured congenital cerebral aneurysm.
The Psychotherapist's Duty to Warn or Protect
Authors: T. Byram Karasu
Journal: JAMA (1990)

In 1982 in Los Angeles, Dr Anderson was sued by Mrs Handler, the wife of his patient (Mr Handler), who had caused her a severe burn injury by setting their house on fire. Dr Anderson was also sued by both Mrs Caspe, a neighbor who claimed that she suffered emotional trauma in experiencing the incident, and by the landlord of the house for the property damage that was done. At the time of the incident, Dr Anderson had already been sued by Mr Handler himself because the good doctor warned the patient's wife on two previous occasions of his potential dangerousness, thus violating doctor/ patient confidentiality. In 1987 Dr Anderson quit practicing medicine; he is now a third-year law student at UCLA. In reflecting on the subject, he thinks that the doctor (in this case himself, of course) should also have been sued by the husband of the neighbor, Mr
Reactogenicity of pertussis vaccines.
Authors: J Cameron
Journal: BMJ (1978)

reason to abandon the routine use of postoperative oxygen.If the anaesthetist doesn't want oxygen used he (or she) should say so on the postoperative instructions.This is different from the problem of the oxygen cylinder that may contain something else, and here I agree with Dr Steel that it is necessary to teach and instruct, not that intubation and oxygen administration are wrong, but what to do if these procedures don't seem to work.
460 The relationship between atopy and the response to cold dry air (CDA) and histamine (H) challenge in perennial rhinitis (PR)
Authors: A. Togias, L.M. Lichtenstein, P.S. Norman, R. Bascom, D. Proud, A. Kagey-Sobotka, R.M. Naclerio
Journal: Journal of Allergy and Clinical Immunology (1988)
Fistulas in ano: endoanal ultrasonographic assessment assists decision making for surgery.
Authors: K I Deen, J G Williams, R Hutchinson, M R Keighley, D Kumar
Journal: Gut (1994)

Eighteen patients with a clinical impression of a complex fistula in ano, had anal endosonography to delineate the anatomy of the fistula track and identify associated areas of sepsis. The clinical impression of a complex fistula was refuted by endosonography and subsequent surgical exploration in two cases. Horseshoe tracks were identified in nine (50%) patients and fluid collections, not evident on clinical examination were identified in eight (45%) patients. Accurate identification of the internal opening with a 7 MHz transducer was possible in two (11%) cases. External sphincter damage was evident in four (22%) patients. Surgical findings matched endosonographic appearances in all but one case (94%). Anal endosonography is an accurate and minimally invasive method of delineating the relation of fistula tracks to the anal sphincters and identifying deep areas of sepsis in relation to such fistulas.
Conduit vessel stiffness is increased in central but not peripheral conduit arteries in adults with essential hypertension
Authors: Gary F. Mitchell, Yves Lacourcière, Jean-Pascal Ouellet, Joseph L. Izzo, Joel M. Neutel, Kent Smith, Chunlin Qian, Linda J. Kerwin, Alan J. Block, Marc A. Pfeffer
Journal: Journal of the American College of Cardiology (2002)