tbuckley/cabot-search huggingface dataset:
Colloid Concentration and Albumin Synthesis.
Authors: Marcus A. Rothschild
Journal: Annals of Internal Medicine (1965)

s1 November 1965Colloid Concentration and Albumin Synthesis.Marcus A. Rothschild, M.D., F.A.C.P., Murray Oratz, Ph.D., Sidney S. Schreiber, M.D., F.A.C.P.Marcus A. Rothschild, M.D., F.A.C.P.Search for more papers by this author, Murray Oratz, Ph.D.Search for more papers by this author, Sidney S. Schreiber, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-915_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the presence of hypergammaglobulinemia, and after the administration of gamma globulin and dextran, albumin levels decrease due to a decrease in albumin production. The extravascular albumin pool is conserved. However, in the presence of cortisone and following the administration of thyroid, albumin synthesis increases with a decrease in the extravascular albumin pool. These observations coupled with the oft observed reciprocal changes in albumin and globulin levels in the serum suggested the presence of a colloid osmotic regulatory system affecting control of albumin production and also that such a system might be located in an extravascular site. Albumin metabolism and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Marcus A. Rothschild, M.D., F.A.C.P.; Murray Oratz, Ph.D.; Sidney S. Schreiber, M.D., F.A.C.P.Affiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1965Volume 63, Issue 5Page: 915-915KeywordsAlbuminsAttentionDextranGlobulinsHypergammaglobulinemiaSerum albuminThyroid ePublished: 1 December 2008 Issue Published: 1 November 1965 PDF downloadLoading ...
Letter: Appliances for the disabled.
Authors: C Aitken
Journal: BMJ (1975)

aetiology, largely as a result of the many publications on the subject to which the working party's report refers.Any reduction in the incidence and severity of the intraoperative cardiovascular disturbances is prin- cipally due to the careful preoperative assess- ment and preparation of the patients, the use, when indicated, of alternative operations which do not require methylmethacrylate, and the meticulous care and vigilance exercised by the surgeons and anaesthetists during the procedure itself.If the importance of these simple but effective steps is overlooked again, then plainly the risks of total hip replacement will increase once more.-I am, etc.,
Muscle Uptake on Bone Scintigraphy Mimicking Fracture of the Femur
Authors: CHARLES A. STEWART, MICHAEL E. SIEGEL, RALPH STEIGER
Journal: Clinical Nuclear Medicine (1990)

Muscle uptake of technetium phosphates has been associated with intramuscular injection of iron dextran and meperidine. A case is presented in which muscle uptake of Tc-99m HDP in the thigh appears on anterior view to be in the femur and resembles a fracture line.
A Role for the HOXB7 Homeodomain Protein in DNA Repair
Authors: Ethel Rubin, Xinyan Wu, Tao Zhu, Joyce C.Y. Cheung, Hexin Chen, Annaka Lorincz, Raj K. Pandita, Girdhar G. Sharma, Hyo Chol Ha, Judith Gasson, Les A. Hanakahi, Tej K. Pandita, Saraswati Sukumar
Journal: Cancer Research (2007)

Abstract Homeobox genes encode transcription factors which function in body axis patterning in the developing embryo. Recent evidence suggests that the maintenance of specific HOX expression patterns is necessary for regulating the homeostasis of adult tissues as well. In this study, HOXB7 transformed human mammary epithelial cells, MCF10A, to grow in minimally supplemented medium, to form colonies in Matrigel, and display resistance to ionizing radiation. Searching for protein partners of HOXB7 that might contribute to resistance to ionizing radiation, we identified four HOXB7-binding proteins by GST pull-down/affinity chromatography and confirmed their interactions by coimmunoprecipitation in vivo. Interestingly, all four HOXB7-binding proteins shared functions as genomic caretakers and included members of the DNA-dependent protein kinase holoenzyme (Ku70, Ku80, DNA-PKcs) responsible for DNA double-strand break repair by nonhomologous end joining pathway and poly(ADP) ribose polymerase. Exogenous and endogenous expression of HOXB7 enhanced nonhomologous end joining and DNA repair functions in vitro and in vivo, which were reversed by silencing HOXB7. This is the first mechanistic study providing definitive evidence for the involvement of any HOX protein in DNA double-strand break repair. [Cancer Res 2007;67(4):1527–35]
Urinary Continence and Erectile Function: A Prospective Evaluation of Functional Results after Radical Laparoscopic Prostatectomy
Authors: Laurent Salomon, Aristotelis G Anastasiadis, Ran Katz, Alexandre De La Taille, Fabien Saint, Dimitrios Vordos, Anthony Cicco, Andras Hoznek, Dominique Chopin, Clement-Claude Abbou
Journal: European Urology (2002)
STUDIES IN THE RELATION OF THE HEMOLYTIC STREPTOCOCCUS TO RHEUMATIC FEVER
Authors: T. N. Harris
Journal: The Journal of Experimental Medicine (1948)

AFTER DISINTEGRATION BY SONIC VIBRATIONS THE CONTENTS OF THE HEMOLYTIC STREPTOCOCCUS CAN BE SEPARATED BY DIFFERENTIAL CENTRIFUGATION INTO THREE FRACTIONS: an insoluble residue, cytoplasmic particles, and a solution of proteins of smaller unit size. The residue (R) presumably comprises the cell walls of the bacteria and contains the type-specific M protein. The cytoplasmic particles (CP) contain some lipoid, the group-specific carbohydrate, and nucleoprotein of the ribose type. The supernate fraction (S) contains two components, presumably protein, at least one of which is part of a dissociable nucleoprotein of the desoxyribose type. Both CP and S precipitate and fix complement with antistreptococcal sera. Both give rise to antibodies on injection into rabbits. Both are of broad reactivity. CP and S can be shown to be serologically distinct by several means, including cross-absorption tests. On continued disintegration of the organism an inverse relation is noted between the yield of R and that of CP, whereas the yield of S is constant. A theory as to the structure of the streptococcal cell is offered in terms of the data presented.
Final results of a multicenter trial addressing role of CSF flow cytometric analysis in NHL patients at high risk for CNS dissemination
Authors: Giulia Benevolo, Alessandra Stacchini, Michele Spina, Andrés J. M. Ferreri, Marcella Arras, Laura Bellio, Barbara Botto, Pietro Bulian, Maria Cantonetti, Lorella Depaoli, Nicola Di Renzo, Alice Di Rocco, Andrea Evangelista, Silvia Franceschetti, Laura Godio, Francesco Mannelli, Vincenzo Pavone, Pietro Pioltelli, Umberto Vitolo, Enrico M. Pogliani
Journal: Blood (2012)
Chelation therapy and autism
Authors: Yashwant Sinha, Natalie Silove, Katrina Williams
Journal: BMJ (2006)

EDITOR—More children are being diagnosed as having autism, and there are currently no treatments based on aetiology.1 Consequently, a number of controversial, unproved, alternative treatments have arisen. The recent death of an autistic child after a medication error with intravenous chelation therapy has brought one purported aetiology based treatment to international attention.2 The 5 year old child reportedly died from hypocalcaemia after …
Nail psoriasis: a questionnaire-based survey
Authors: K.M.G. Klaassen, P.C.M. van de Kerkhof, M.C. Pasch
Journal: British Journal of Dermatology (2013)

Skin manifestations are the most characteristic finding of psoriasis. However, nail involvement is also a clinical feature of disease although it is often overlooked. The documented prevalence of nail psoriasis varies between 10·0% and 81·1%.The aim of this investigation is to gain knowledge about the prevalence and clinical manifestations of nail psoriasis and patient experiences of treatment of nail psoriasis.A structured, self-administered questionnaire was distributed to all members (n = 5400) of the Dutch Psoriasis Association. The questionnaire enquired about sociodemographic patient characteristics, disease-related data and treatment of nail psoriasis. Patients reported their nail manifestations with photographs after instruction. Patients with nail psoriasis were compared with patients without nail psoriasis.A response rate of 27% was achieved. The prevalence of nail psoriasis was 66·0%. The most frequently observed psoriatic nail manifestation was pitting (65·4%), whereas red spots in the lunula were infrequently seen (6·5%). Patients with nail psoriasis more frequently stated psoriasis capitis (75·8% vs. 65·7%), genital psoriasis (32·7% vs. 20·3%) and psoriatic arthritis (46·4% vs. 30·6%) compared with patients with psoriasis without nail involvement. Only 16·0% of patients received treatment for nail psoriasis. Systemic therapies were most frequently stated as being effective for nail lesions.Nail manifestations seem to be more prevalent in patients with psoriasis than previously thought. In addition, nail psoriasis is shown to be associated with widespread and more severe forms of psoriasis, and different treatment options are experienced as being effective for nail psoriasis. Notwithstanding, nail psoriasis is still an often overlooked feature of the disease.
Women in Medicine
Authors: MARY LORETTA ROSENLUND
Journal: Annals of Internal Medicine (1967)

Special Article1 May 1967Women in MedicineMARY LORETTA ROSENLUND, M.D., FRANK A. OSKI, M.D.MARY LORETTA ROSENLUND, M.D.Search for more papers by this author, FRANK A. OSKI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1008 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough increasing attention is now being paid to the possibility of an impending shortage of physicians, little thought has been given to the present sources of physician attrition. Many believe that one large group in the medical community that does not contribute its share to the practice of medicine is that comprised of female physicians. Much prejudice and little published fact are available for those wishing to draw their own unbiased conclusions. Opinions concerning the role of women in medicine range to the extremes. Some contend that women are an unnecessary expense to medical schools because so many of them...References1. STEPHENS J: The Crock of Gold, 1st ed. The Macmillan Co., New York, 1913, p. 17. Google Scholar2. DYKMANSTALNAKER RAJM: Survey of women physicians graduating from medical school 1925-1940. J. Med. Educ. 32 (suppl. 1): 3, 1957. MedlineGoogle Scholar3. Women in Medicine: The Results of an Inquiry Conducted by the Medical Practitioners' Union in 1962-1963. Office of Health Economics, London, 1966. Google Scholar4. BUCKSCOFFIELDWARWICK CMOH: A survey of women graduates from a Canadian medical school. Canad. Med. Ass. J. 94: 712, 1966. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARY LORETTA ROSENLUND, M.D.; FRANK A. OSKI, M.D.Affiliations: Philadelphia, PennsylvaniaFrom the Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pa.This study was supported in part by grant AM 02231, U. S. Public Health Service, Washington, D. C.Requests for reprints should be addressed to Frank A. Oski, M.D., Hospital of the University of Pennsylvania, 3600 Spruce St., Philadelphia, Pa. 19104. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCUMC Women: After the M.D., What? Report of Survey of Female Graduates of 1940–1969Review Article : Physicians' Background Characteristics and their Career Choices: a Review of the LiteratureWhat Is Different for Women Physicians?The effect of two sources of role strain on women physiciansComparison of employment status of women medical graduates and women science graduates, University of Sheffield, 1960-65American and Soviet Medical Manpower: Growth and Evolution, 1910–1970Women and Medical Sociology: Invisible Professionals and Ubiquitous PatientsUnderemployment of Women PhysiciansMARJORIE J. WILLIAMS, M.D. 1 May 1967Volume 66, Issue 5Page: 1008-1012KeywordsAlumniMedical servicesPediatrics ePublished: 1 December 2008 Issue Published: 1 May 1967 PDF downloadLoading ...
RETRODISPLACEMENTS OF THE UTERUS.A FURTHER REPORT ON OPERATIONS ON THE UTEROSACRAL AND ROUND LIGAMENTS.
Authors: J. WESLEY BOVéE
Journal: JAMA (1903)

At the meeting of the American Gynecological Society in 1902,<sup>1</sup>and the following month before this Section,<sup>2</sup>I presented this subject, reporting 8 cases operated on by the vaginal and 3 by the abdominal route. At this time I desire to report 17 cases operated on by each of the two routes, together with some points noted from this experience. There has been no fatality or even notable morbidity in the 41 cases. In every instance of shortening the round ligaments the plan suggested by Webster and Baldy has been practiced. Curettage was done in every one of the 17 vaginal operations. In 3 of them trachelorrhaphy was done in addition, and in 8 perineorrhaphy and trachelorrhaphy. In one of these anterior and posterior colporrhaphy was added; in another posterior colporrhaphy up to the vaginal roof was done. In one the anterior vaginal wall was
Medical theories on the cause of death in crucifixion
Authors: J. Scotson
Journal: Journal of the Royal Society of Medicine (2006)

The editorial 'Too little quality; too many doctors' (June 2006 JRSM 1 ) is incorrect to suggest that the General Medical Council (GMC) had a 'sudden demand for overseas graduates to have a work permit'.The GMC does not have any visa requirements for international medical graduates (IMGs).The Home Office is responsible for setting visa requirements.International medical graduates are responsible for ensuring that they have the appropriate visa when they enter the UK.
Abstract 1327: Analysis of metal content and distribution in profiling normal and tumor tissues from three human carcinomas
Authors: Ibrahim O. Farah, Phoung X. Nguyen
Journal: Cancer Research (2011)

Abstract Studies have shown that elemental/metal homeostasis is very essential to the development of the cancer phenotype in many cancers including lung and liver carcinomas. The balance in the composition of trace elements/metals was recognized to be essential to normal homeostasis. Low Zn levels were implicated in the development of prostate as well as other cancers. The aim of this study was to investigate the differential relationship of metal concentrations and profiles in cancer and normal tissues of humans. It is hypothesized that essential elements/metal concentrations and profiles will show significant differences between cancer and normal tissues as well as between different tissue types in human tissue material. The study will establish critical element/metal profiles that provide correlations with the development of three major carcinomas. Normal human and tumor tissues of lung, breast and liver tissues used in this study were obtained from US Biomax Company. Tissue samples were prepared using standardized digestion procedure and the ICP-AES (Inductively Coupled Plasma-Atomic Emission Spectrometry) was used to determine the concentrations and profiles of 21 elements including Ag, Al, As, Ba, Ca, Cd, Co, Cr, Cu, Fe, Mg, Mn, Na, Ni, Pb, Sb, Se, Sr, Tl, V, and Zn. Results showed that nine major elements of Al, Ba, Ca, Cr, Cu, Fe, Mg, Na, and Zn were found to be significantly different in term of their concentration profiles in normal and tumor tissues of human lung, breast and liver. It is concluded that metal/elemental homeostasis is essential for normal tissue function and that shifts in elemental distribution and content are tissue specific as well as carcinoma specific. These results are promising and warrant further studies to exploit the possibility of manipulating elemental content and distribution as a cancer therapeutic modality. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1327. doi:10.1158/1538-7445.AM2011-1327
Protective Role of CD40 in Leishmania major Infection at Two Distinct Phases of Cell-Mediated Immunity
Authors: Masahito Kamanaka, Philipp Yu, Teruhito Yasui, Kenji Yoshida, Tsutomu Kawabe, Toshihiro Horii, Tadamitsu Kishimoto, Hitoshi Kikutani
Journal: Immunity (1996)
Data, development, and dual processes in rationality
Authors: Valerie F. Reyna
Journal: Behavioral and Brain Sciences (2000)

Although Stanovich &amp; West (S&amp;W) are likely to be criticized for not proposing a process model, results of such a model (fuzzy-trace theory) support many of their conclusions. However, arguments concerning evolution and Gricean intelligence are weak. Finally, developmental data are relevant to rationality, but contradictory results suggest a dual-processes approach that differs from S&amp;W's based on fuzzy-trace theory.
Measles virus-substance P receptor interactions. Possible novel mechanism of viral fusion.
Authors: G Harrowe, M Mitsuhashi, D G Payan
Journal: Journal of Clinical Investigation (1990)

Measles virus (MV) encodes the fusion protein (F) that mediates cell fusion and intercellular spread of the virus, and is homologous to the carboxy terminus of the neuropeptide substance P (SP). In addition, the oligopeptide Z-D-Phe-L-Phe-Gly, also homologous to F and SP, inhibits MV fusion with target cells. These observations raise the question of whether MV uses the SP receptor (SPR) during a specific phase of its infectious cycle. In this report, we examine the structural and functional consequences of this interaction and show, using cross-linking studies, that MV and SP specifically bind to a 52-58-kD protein, previously reported to comprise the SPR on human IM-9 lymphoblasts. Moreover, bound MV and SP are shown to reciprocally displace each other from these cells. In addition, we demonstrate that anti-SP antisera inhibits the cell-to-cell spread of MV, and that SP blocks MV fusion with target cells. These results indicate the presence of MV-SPR interactions during viral fusion, and suggest possible novel mechanisms for viral entry into cells.
Climate change, ill health, and conflict
Authors: L. Jarvis, H. Montgomery, N. Morisetti, I. Gilmore
Journal: BMJ (2011)

Are interrelated, so collaboration between medical and military professions is needed

Damage to the fabric of human society is bad for human health. It can occur for reasons other than war. A recent report by the International Institute for Strategic Studies (IISS) has highlighted that the effects of climate change will present a threat to collective security and global order in the first half of the 21st century.1 This will limit access to food, safe water, power, sanitation, and health services and drive mass migration and competition for remaining resources. Starvation, diarrhoea, and infectious diseases will become more common, and neonatal and adult mortality will rise, as a result of conflict.2 In accordance with this, in 2004, seven of the 10 countries with the highest mortality rates in children under 5 were conflict or immediate post-conflict societies.3.

The IISS report states that “The earth is warming, and has been for at least a century,” with this being “directly attributable to the increasing emission of carbon dioxide and other greenhouse gases.” As a result, “Climate change may already be changing weather and precipitation patterns” and will continue to drive extreme weather events and changes in water resources (through flood, drought, and …
A CASE OF ANEURISM OPERATED ON BY THE MATAS METHOD.
Authors: ISRAEL BROWN
Journal: JAMA (1906)

<h3>Patient.</h3> —C. I., colored, aged 51, native of North Carolina. <h3>History.</h3> —Family history was negative. Personal history showed usual diseases of childhood and gonorrhea 8 years ago. Formerly, patient was a heavy drinker and used tobacco in moderation for a number of years. In January, 1906, he was taken with pain in right leg extending from knee to ankle, which was treated for some time as rheumatism. Pain was worse at night and unrelieved by posture or pressure. There was a pulsating tumor in the right popliteal space, supposed to have been caused by pressure and irritation produced by wearing high rubber boots. Patient was admitted to St. Vincent's Hospital, May 22, 1906. <h3>Exmination.</h3> —Heart, lungs, etc., were normal; there was very little hardening of the arteries. The tumor was hard, slightly elastic, and very painful. There was considerable edema of the leg. <h3>Operation.</h3> —May 25, 1906. incision was made
Conditional Depletion of Airway Progenitor Cells Induces Peribronchiolar Fibrosis
Authors: Anne-Karina T. Perl, Dieter Riethmacher, Jeffrey A. Whitsett
Journal: American Journal of Respiratory and Critical Care Medicine (2010)

Rationale: The respiratory epithelium has a remarkable capacity to respond to acute injury. In contrast, repeated epithelial injury is often associated with abnormal repair, inflammation, and fibrosis. There is increasing evidence that nonciliated epithelial cells play important roles in the repair of the bronchiolar epithelium after acute injury. Cellular processes underlying the repair and remodeling of the lung after chronic epithelial injury are poorly understood.Objectives: To identify cell processes mediating epithelial regeneration and remodeling after acute and chronic Clara cell depletion.Methods: A transgenic mouse model was generated to conditionally express diphtheria toxin A to ablate Clara cells in the adult lung. Epithelial regeneration and peribronchiolar fibrosis were assessed after acute and chronic Clara cell depletion.Measurements and Main Results: Acute Clara cell ablation caused squamous metaplasia of ciliated cells and induced proliferation of residual progenitor cells. Ciliated cells in the bronchioles and pro–surfactant protein C–expressing cells in the bronchiolar alveolar duct junctions did not proliferate. Epithelial cell proliferation occurred at multiple sites along the airways and was not selectively associated with regions around neuroepithelial bodies. Chronic Clara cell depletion resulted in ineffective repair and caused peribronchiolar fibrosis.Conclusions: Colocalization of proliferation and cell type–specific markers demonstrate that Clara cells are critical airway progenitor cells. Continuous depletion of Clara cells resulted in persistent squamous metaplasia, lack of normal reepithelialization, and peribronchiolar fibrosis. Induction of proliferation in subepithelial fibroblasts supports the concept that chronic epithelial depletion caused peribronchiolar fibrosis.
Incidence of Diabetes Among Dependents of the U.S. Military Forces Admitted to U.S. Army Treatment Facilities, 1971-1991
Authors: Chandra M Tiwary, Joel E Michalek
Journal: Diabetes Care (1995)

To determine the national incidence of diabetes in children by studying a group representing all parts of the country: the dependent children of U.S. military personnel.Dates of admission, diagnosis of diabetes, age, and gender were collected for all 522,326 children, age 21 or younger, of active duty military personnel admitted to U.S. Army treatment facilities during fiscal years 1971-1991. Incidence rates were expressed as cases per 100,000 person-years.A total of 2,308 cases of diabetes were diagnosed in 14.3 million person-years of follow-up over the 21 years. The overall incidence rate of diabetes in this population is 16.2 (95% confidence interval 15.5-16.9). For 1987-1991, the age-specific rates were 8.1 (0-4 years), 15.9 (5-9 years), 25.6 (10-14 years), 23.9 (15-19 years), and 23.4 (20-21 years).The rates may be biased because of exclusion of people with diabetes from entering military service, and are limited by lack of age adjustment. The racial admixture of our study population does not match the U.S. population as a whole.