tbuckley/cabot-search huggingface dataset:
Challenge pregnant women to manage their weight, NICE says
Authors: A. Sayburn
Journal: BMJ (2010)

Myths about pregnancy and weight—such as that pregnant women need to “eat for two”—need to be challenged by GPs, midwives, and other healthcare workers, says new guidance from the UK National Institute for Health and Clinical Excellence (NICE).

Obese women and their unborn babies face serious health risks, including a raised risk of miscarriage, stillbirth, pre-eclampsia, and gestational diabetes, it says. Women need reliable information on how to manage their weight before, during, and after their pregnancy.

The team that produced the guidance says that healthcare professionals such as GPs and midwives don’t routinely provide this advice and that many healthcare professionals are …
Oxidation Reduction in Heart Muscle
Authors: S. GUDBJARNASON, R. O. HAYDEN, V. E. WENDT, T. B. STOCK, R. J. BING
Journal: Circulation (1962)

MEASUREMENT of the extraction of substrates by the heart is the only means for obtaining information on possible alterations in cardiac metabolism in man or the intact animal; however, because of storage and interchange, arteriovenous differences re- flect only balances and give little information on pathways of intermediary metabolism.'In addition, the validity of balance studies depends on a steady state in which blood flow, arterial concentration, and tissue metabolism remain constant during the period of observa- tion.2Extraction of substrates, however, may reflect their fate in the cell, and thus can be utilized in the investigation of intermediary metabolism.It is the purpose of this report to point out that changes in the redox poten- tial of a certain redox system in the blood perfusing the heart muscle reflect alterations within the heart muscle cell.The information obtained will be utilized in the study of conditions in which alterations in redox potential accompany clinical manifestations of the myo- cardial disease. The Hydrogen Transfer SystemThe metabolic activities in cardiac muscle reflect the function that the heart performs.
A 35-Year-Old Man With Epigastric Pain
Authors: Robert Glickman
Journal: JAMA (1995)

<h3>Dr Daley</h3> : Mr H is a 35-year-old registered nurse who has recurrent episodes of epigastric pain. Divorced and the father of one child, he works in a local hospital and receives private health insurance through his employer. Since he was a child, Mr H has experienced intermittent pain in the epigastric area that radiates to the back. When the pain is mild, he describes it as burning, sometimes accompanied by chest heaviness or tightness. When the pain is severe, Mr H describes it as "a hot knife being pushed under my rib cage and out my back." His symptoms are aggravated by emotional stress, alcohol, cigarettes, and spicy foods. He denies nausea, vomiting, melena, hematemesis, symptoms of reflux, or anemia. He has never taken aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs). For many years, he took large quantities of antacids to relieve the pain, and sucralfate and cimetidine have also provided
Stimulation of Glucose Oxidation in Thyroid by Thyroid Stimulating Hormone (TSH) and Other Substances.
Authors: I. Pastan
Journal: Annals of Internal Medicine (1961)

s1 May 1961Stimulation of Glucose Oxidation in Thyroid by Thyroid Stimulating Hormone (TSH) and Other Substances.I. Pastan, M.D., J. B. Field, M.D.I. Pastan, M.D.Search for more papers by this author, J. B. Field, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1046_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough TSH has been shown to increase thyroid growth, respiration, iodine, and phospholipid metabolism, its mechanism of action is unknown. We noted that the oxidation of glucose-1-C14and glucose-6-C14to C14O2by thyroid slices in vitro was stimulated five minutes after the addition of TSH. This early effect suggested that TSH acts directly on glucose oxidation or a closely related metabolic step, and that previously noted effects of TSH were secondary. This stimulation of glucose oxidation was specific since: (1) TSH had no effect on the glucose oxidation of many other tissues; (2) none of the other anterior pituitary hormones... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1961Volume 54, Issue 5Page: 1046-1047KeywordsGlucosePhospholipidsProlactinRespirationThyroidThyroid-stimulating hormone ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...
Abstract 14918: Invalidation Of Trpm4 Channel In Mouse Induces Slowed Cardiac Conduction, Arrhythmias And Hyperplasia
Authors: Marie Demion, Jerome Thireau, Cassan Cecile, Serafini Nicolas, Aimond Franck, Guinamard Romain, Launay Pierre, Richard Sylvain
Journal: Circulation (2011)

Background:  TRPM4 channel is selective for Na+ and K+, activated by intracellular Ca2+ and blocked by intracellular ATP. It was recently demonstrated to be involved in human cardiac rhythm defects when TRPM4 is over expressed while its physiological role in the heart is unclear, in particular in electrical conduction and rhythm control.   Method:  We used a knock-out mouse model for Trpm4 gene (Trpm4-/-). Electrophysiologic explorations (electrocardiogram in vigil mice and intracardiac exploration), echocardiographic analyses, frozen hearts cryosections, qPCR and cellular electrophysiology were performed for in vivo and in vitro analyses.   Results:  Electrical conduction was lengthened in absence of the TRPM4 channel (PR and QRS intervals were 39±0.5 vs. 42.3±0.3; and 16.8±0.5 vs. 19.4±0.4. ms; for Trpm4+/+ (n=13) and Trpm4-/- (n=18) mice). Both the suprahisian (AH) and infrahisian (HV) conduction times were increased in Trpm4-/- mice compared to Trpm4+/+ (n=6). Trpm4-/- mice also exhibited a high incidence of atrioventricular blocks exclusively after a progressive prolongation of the few PR intervals preceding the blocks. Trpm4-/- mice developed frequent ectopic atrial activities not observed in Trpm4+/+ mice. We then investigated the cardiac morphology and function. The Trpm4-/- mice exhibited increased left ventricular (LV) mass (2.62±0.17 vs. 3.14±0.16 mg/g, n=11 for Trpm4+/+ and 14 Trpm4-/- mice) and LV dilation (0.85±0.03 in Trpm4+/+ vs. 0.96±0.03 10-1 mm/g in Trpm4-/-). By different techniques, we excluded the hypothesis of pro-fribotic phenotype or increased LV cardiomyocytes size. We thus assessed the hyperplasic status of cardiomyocytes during cardiomyogenesis by staining of phospho-histone H3 (P-H3), a mitosis marker, in heart cryosections one day after birth. P-H3 staining was increased 3-fold throughout the heart of Trpm4-/-.   Conclusion:  Taken together, all these data suggest that TRPM4 invalidation is associated with pathophysiological phenotype characterized by conduction disorders, arrhythmias and hypertrophy due to neonate hyperplasia.
DO UPDATED ECG INTERPRETATION CRITERIA RESULT IN ACCEPTABLE RATES OF FURTHER CARDIAC TESTING IN NCAA DIVISION 1 ATHLETES UNDERGOING ECG–BASED PREPARTICIPATION SCREENING?
Authors: Christine E. Lawless, Lonnie Albers, David Marx, Lori Heiss, Mathue Baker, Todd Tessendorf, Steven Krueger
Journal: Journal of the American College of Cardiology (2013)
Mitochondrial Myopathy with a Defect of Mitochondrial-Protein Transport
Authors: Anthony H.V. Schapira, J. Mark Cooper, John A. Morgan-Hughes, David N. Landon, John B. Clark
Journal: New England Journal of Medicine (1990)

The clinical and biochemical heterogeneity of the mitochondrial myopathies is now well established.1 , 2 Recent work has focused on identifying the molecular basis of these disorders and has demons...
Preempting the Memory of Pain
Authors: Daniel B. Carr
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In vitro characterization of DNA adducts formed by foundry air particulate matter.
Authors: K Savela, M J Kohan, D Walsh, F P Perera, K Hemminki, J Lewtas
Journal: Environmental Health Perspectives (1996)

This study is part of an ongoing investigation of biomarkers in iron foundry workers exposed to polycyclic aromatic compounds. Foundry workers with the highest exposures had elevated levels of DNA adducts in their white blood cells in previous studies. The purpose of this study was to characterize the nature of DNA reactive chemicals in foundry air samples through incubating the foundry filter extract with DNA and activation enzymes. Calf thymus DNA was incubated with foundry filter extract and activated by either rat liver activation mixture (S9 mix) or xanthine oxidase. A complex pattern of adducts was observed on thin-layer chromatography (TLC) by the 32P-postlabeling assay. Two selected polycyclic aromatic hydrocarbons (PAHs)--1-NP-and anti(+/-)benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide [anti(+/-) BPDE]-DNA adducts--were used as marker compounds in characterizing the postlabeled DNA adducts by TLC combined with high-performance liquid chromatography (HPLC). After an initial separation of DNA adducts by TLC, individual spots were isolated and separated further on HPLC. HPLC analysis and spiking with anti(+/-)BPDE-DNA standard confirmed the co-migration of the anti(+/-)BPDE-DNA standard with one PAH adduct formed by the S9 mix-activated DCM extract in calf thymus DNA.
Cdk5-Mediated Inhibition of the Protective Effects of Transcription Factor MEF2 in Neurotoxicity-Induced Apoptosis
Authors: Xiaoming Gong, Xiaoli Tang, Marcus Wiedmann, Xuemin Wang, Junmin Peng, Dong Zheng, Leslie A.C. Blair, John Marshall, Zixu Mao
Journal: Neuron (2003)
1096. FSTL_1 Is a Novel Pro_Inflammatory Protein
Authors: Takako Miyamae, AnthonyD. Marinov, David C. Wilson, Raphael Hirsch
Journal: Molecular Therapy (2006)

Follistatin-like protein (FSTL-1) is a secreted glycoprotein with a molecular weight of 40-55 KD that contains a follistatin-like domain. FSTL-1 was first isolated from a cDNA library of mouse osteoblastic cells as a transforming growth factor-|[beta]|1-inducible gene. Its function has not yet been fully elucidated. We found increased expression of FSTL-1 mRNA by microarray analysis of joints of mice with collagen-induced arthritis (CIA). In situ hybridization and immunohistochemistry revealed increased expression along the margin of contact between the inflammatory synovium and eroding bone. We determined by immunohistochemistry that the source of FSTL-1 was fibroblast-like synoviocytes. The highest level of FSTL-1 expression was seen during the acute phase of CIA. When CIA mice received a non-replicating adenoviral vector encoding FSTL-1 (Ad-FSTL1) intravenously one week before the onset of arthritis, the mice developed earlier and more severe disease, compared to mice administered a control virus. This result suggests that over-expression of FSTL-1 exacerbates collagen-induced arthritis. To investigate the role of FSTL-1 in inflammation, normal DBA-1 mice received Ad-FSTL1 intravenously or in the footpad. Results of quantitative RT-PCR from the livers of mice treated intravenously with Ad-FSTL1 showed increased IL-1|[beta]| , IL-6, and TNF|[alpha]| expression compared to control group. Mice receiving Ad-FSTL1 in the footpad showed significant swelling and increased IL-1|[beta]| and IL-6 protein compared to the controls. In addition to in vivo experiments, we stably-transfected the human monocyte cell line, U937, with FSTL-1. Although these cells did not spontaneously produce inflammatory cytokines, addition of PMA to induce differentiation into macrophages led to secretion of IL-1|[beta]|, TNF-|[alpha]|, and IL-6. A substantial synergistic effect was observed upon addition of LPS, suggesting that FSTL-1 utilizes a distinct signaling pathway different from the LPS receptor. These results suggest that FSTL-1 is a pro- inflammatory molecule that might serve as a novel target for therapy of arthritis or other inflammatory diseases.
Preliminary Observations on the Effect of Fenfluramine on Blood Serotonin and Symptoms in Three Autistic Boys
Authors: Edward Geller, Edward R. Ritvo, Betty Jo Freeman, Arthur Yuwiler
Journal: New England Journal of Medicine (1982)

THE syndrome of autism is a pervasive developmental disorder. It is diagnosed by the presence before 30 months of age of disturbances in the rate of development and coordination of physical, social, and language skills, abnormal responses to sensory inputs (hyperreactivity alternates with hyporeactivity), absence of speech and language or a delay in acquiring them although specific cognitive capacities may be present, and disturbance of the capacity to relate appropriately to people, events, and objects.1 , 2 Autistic persons have been identified throughout the world and come from all races and social classes. No psychological or other factors have been identified that . . .
Biological and Clinical Implications of Heat Shock Protein 27000 (Hsp27): a Review
Authors: D. R. Ciocca, S. Oesterreich, G. C. Chamness, W. L. MCGuire, S. A. W. Fuqua
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Biological and Clinical Implications of Heat Shock Protein 27000 (Hsp27): a Review Get access Daniel R. Ciocca, Daniel R. Ciocca Department of Medicine, Division of Medical Oncology, The University of Texas Health Science CenterSan Antonio Present address : D. R. Ciocca, Laboratorio de Reproduccion y Lactancia (LARLAC), Centro Regional de Investigaciones Cientificas y Tecnicas, C.C.855, 5500 Mendoza, Argentina. Search for other works by this author on: Oxford Academic PubMed Google Scholar Steffi Oesterreich, Steffi Oesterreich Department of Medicine, Division of Medical Oncology, The University of Texas Health Science CenterSan Antonio Search for other works by this author on: Oxford Academic PubMed Google Scholar Gary C. Chamness, Gary C. Chamness Department of Medicine, Division of Medical Oncology, The University of Texas Health Science CenterSan Antonio Search for other works by this author on: Oxford Academic PubMed Google Scholar William L. MCGuire, William L. MCGuire Department of Medicine, Division of Medical Oncology, The University of Texas Health Science CenterSan Antonio Search for other works by this author on: Oxford Academic PubMed Google Scholar Suzanne A. W. Fuqua Suzanne A. W. Fuqua Department of Medicine, Division of Medical Oncology, The University of Texas Health Science CenterSan Antonio * See "Notes" section following "References." Suzanne A. W. Fuqua, Ph.D., Medicine/Oncology, UTHSCSA, 7703 Floyd Curl Drive, San Antonio, TX 78284-7884. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 19, 6 October 1993, Pages 1558–1570, https://doi.org/10.1093/jnci/85.19.1558 Published: 06 October 1993 Article history Received: 25 January 1993 Revision received: 03 June 1993 Accepted: 10 June 1993 Published: 06 October 1993
Radiologic Anatomy: Interactive Educational Courseware on the Fundamentals of Normal Radiology
Authors: Paul Johnstone
Journal: JAMA (1995)

When I first agreed to review software for the<i>Journal of the American Medical Association</i>, I was skeptical of the applicability of what would arrive. For three years I have undertaken a search for educational medical software. I began using computers in 1982 and have used them in all phases of my education. When I began medical school in 1992, I had hoped to use this resource to supplement my education and training. Unfortunately, the software available was limited to what was designed for the layperson. In 1994 I began to work with ADAM (Animated Dissection of Anatomy for Medicine) in hopes of finally being able to join my interests of computers and medicine. While ADAM was a leap forward in the area of complexity and applicability, it left me having to rely heavily on books (Netter and Grant) to get the detail I felt was necessary to be competent
Managing Ob/Gyn Emergencies
Authors: Jack Maidman
Journal: JAMA (1982)

This book was adapted from a special issue of<i>Contemporary Ob/Gyn</i>. Although intended to contribute to the clinician's continuing medical education, it may be far more useful as a handbook for obstetric and gynecologic emergencies. The book is divided into 17 chapters, written by different authors. Subjects range from vasovagal syncopy to abdominal emergencies in pregnancy, ruptured pelvic abscesses, eclampsia, and the ruptured uterus. Each chapter is concise, and many contain short boxes outlining a management formula. Important current references are provided. Although the format using independent authors leads to some unevenness, the overall quality of the chapters is good. Some relatively frequent emergencies, such as diabetic ketoacidosis and asthma and their respiratory emergencies, have been overlooked. Nevertheless, this is a volume one would like to have in one's locker when the 3 AM emergency patient is rolled in. It is hoped that the omissions will be corrected in future
The Architecture and Evolution of Cancer Neochromosomes
Authors: Dale W. Garsed, Owen J. Marshall, Vincent D.A. Corbin, Arthur Hsu, Leon Di Stefano, Jan Schröder, Jason Li, Zhi-Ping Feng, Bo W. Kim, Mark Kowarsky, Ben Lansdell, Ross Brookwell, Ola Myklebost, Leonardo Meza-Zepeda, Andrew J. Holloway, Florence Pedeutour, K.H. Andy Choo, Michael A. Damore, Andrew J. Deans, Anthony T. Papenfuss, David M. Thomas
Journal: Cancer Cell (2014)
FATAL CASE OF ANEURYSM OF THE SPLENIC ARTERY
Authors: D. C. L. Fitzwilliams
Journal: BMJ (1924)

TiE child to be described first came u-nder niotice at the age of 12 months, anid the reasoni for the child being sent to the hospital was the dark red colour of the teetlh.The case was thieni thoroughly inlvestigated, anid proved to be an ex.amliple of haematopolphyria coiigeniita.Very few of tile CzIcses have as yet been i ecognized anid recorded so.early ill Efe.Sir A. E. Gairrod aind Mackey' report onie similar case, uimd I am indebted to the forn ci's book, Inborn Errors of MetabolismJ 2 for lielp.The child was apparently born healthy and had had no illness of noto.She hiad been easy to " bring up."All her life, however,
Decisions Regarding Resuscitation of Extremely Premature Infants
Authors: Renee D. Boss, Carrie M. Henderson, Benjamin S. Wilfond
Journal: JAMA Pediatrics (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Request for Specimens
Authors: Leonard W. Ely
Journal: JAMA (1910)

<h3>To the Editor:—</h3> May I ask through your columns for a few specimens? I need particularly a specimen of a tuberculous spine, a tuberculous sternoclavicular articulation and a tuberculous sacro-iliac articulation. If any of your readers, on removing one of these at autopsy will place it in a 2 per cent. dilution of liquor formaldehyde and will send it to me. I shall be glad to pay expressage, and shall be very grateful to him.
Hazards of Subclavian Vein Cannulation for Central Venous Pressure Monitoring
Authors: Max Schapira
Journal: JAMA (1967)

In four cases, serious complications were encountered after the insertion of a central venous catheter into the subclavian veins. Pneumothorax developed in three patients and one had a hemothorax. Two patients who had massive pneumothorax died, the other two recovered. On the basis of the experience obtained by others and ourselves with the measurements of central venous pressure through catheters inserted via the subclavian vein, the abandonment of this technique has been recommended.
Effect of diet and triiodothyronine on the activity of sn-glycerol-3-phosphate dehydrogenase and on the metabolism of glucose and pyruvate by adipose tissue of obese patients
Authors: G. A. Bray, Stella Mothon, Andrea Cohen
Journal: Journal of Clinical Investigation (1969)

Lipogenesis and the metabolism of sn-glycerol-3-phosphate were studied in 23 fat biopsies from eight grossly obese patients. The first biopsy was obtained after a minimum of 12 days on a 3500 cal diet, the second biopsy after 2 wk on a 900 cal diet, and the third biopsy after an additional 2 wk on 900 cal supplemented with thiiodothyronine, 250 μg/day.
Oral Moniliasis Complicating Combined Broad-Spectrum-Antibiotic and Antifungal Therapy
Authors: Paul Solomon
Journal: New England Journal of Medicine (1961)

SUPERINFECTION with yeasts or fungi long has been recognized as a complication of broad-spectrum-antibiotic therapy.1 , 2 In this age of multiple-drug therapy the practitioner is likely to be attracted by claims of prevention of secondary infection by specific drug combinations. The following case suggests that this danger may not have been eliminated by the most recent combination of broad-spectrum antibiotic and antifungal agent.Case ReportA 3 1/2-year-old boy was seen by a physician on January 20, 1961, because of symptoms of upper-respiratory-tract infection. Bilateral otitis media was found, along with coarse breath sounds throughout both lung fields. Papules were described . . .
Dynamics of cognition-emotion interface: Coherence breeds familiarity and liking, and does it fast
Authors: Piotr Winkielman, Andrzej Nowak
Journal: Behavioral and Brain Sciences (2005)

We present a dynamical model of interaction between recognition memory and affect, focusing on the phenomenon of “warm glow of familiarity.” In our model, both familiarity and affect reflect quick monitoring of coherence in an attractor neural network. This model parsimoniously explains a variety of empirical phenomena, including mere-exposure and beauty-in-averages effects, and the speed of familiarity and affect judgments.