tbuckley/cabot-search huggingface dataset:
Seat Belt Sentinels
Authors: Tracy Hampton
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy
Authors: Alfredo Dragani, Silvia Pascale, Antonio Recchiuti, Domenico Mattoscio, Stefano Lattanzio, Giovanna Petrucci, Luciana Mucci, Elisabetta Ferrante, Aida Habib, Franco O. Ranelletti, Giovanni Ciabattoni, Giovanni Davì, Carlo Patrono, Bianca Rocca
Journal: Blood (2009)
Abstract 3114: MLL2 overexpression and incomplete proteolytic processing in human cell lines from invasive breast and colon cancers
Authors: Thanemozhi G. Natarajan, Bhaskar V. Kallakury, Christine Sheehan, Margaret B. Bartlett, Natarajan Ganesan, Anju Preet, Jeffrey Ross, Kevin T. FitzGerald
Journal: Cancer Research (2010)

Abstract Background: MLL2 is an epigenetic regulator in mammalian cells and mediates histone 3 lysine 4 tri-methylation (H3K4me3) at specific gene loci, through formation of a multiprotein complex. MLL2 shares a high degree of structural similarity with MLL1, which frequently undergoes translocations resulting in leukemogenic fusion oncoproteins. Despite the structural similarity with MLL1, MLL2 is not involved in leukemias. Earlier we reported aberrant MLL2 expression in human breast and colonic tumor tissues compared to normal tissues. In continuation with the above study, we now present the results of MLL2 investigation in cell lines from human breast and colon cancers. Methods: Established cell lines from human mammary and colonic tissues were cultured under optimal conditions. Cells were processed for nuclear and cytoplasmic fractionation as well as DNA and total RNA extraction. Nuclear and cytoplasmic extracts were separated on polyacrylamide gels and immunoblotted for MLL2. The RNA extracts were used to determine MLL2 transcript levels by one-step reverse transcriptase-PCR using appropriate primers. The DNA extracts were used to amplify MLL2 specific sequences using appropriate primers, followed by sequencing reaction. Result: Examination of cell lines revealed 2-3 fold increase in MLL2 transcript levels in the highly invasive tumor cell lines of both breast and colon. Expression of MLL2 at protein level was consistent with the transcript levels, indicating MLL2 overexpression as the cause of increased protein levels in the tumor cells. Additionally, we also observed incomplete proteolytic processing of MLL2 in the highly invasive cell lines from either tissue types, compared to the corresponding non-tumor/less invasive tumor cell lines. Interestingly, the unprocessed full length MLL2 was significantly abundant in the nuclear compartments of the highly invasive tumor cell lines. Analysis of the coding sequences for the putative cleavage site did not reveal any alterations. Conclusion: We conclude that MLL2 expression and proteolytic processing are both deregulated in breast and colon cancers. This deregulation may be associated with mammary and colonic tumor growth/progression. Given the epigenetic regulatory role, further investigation is required to study MLL2 involvement in tumorigenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3114.
Fatal Anaphylactic Shock
Authors: B. Hugh Buff
Journal: JAMA (1960)

For more than 35 years, the medical literature has contained numerous publications concerning (1) the prevention of the 50% fatal disease tetanus, by either active or passive immunization, and (2) the dangers and severe reactions resulting from the use of horse serum in the passive type of prevention. The following case, however, is the first report of a death occurring as the direct result of an intracutaneous skin test of a dilute dose of tetanus antitoxin obtained from horse serum. <h3>Case Report</h3> A 59-year-old man was seen in the office with the complaint of a puncture wound of the right palm, made with a knife, the cleanliness of which was questionable. The patient did not know of ever having had an injection of horse serum or tetanus antitoxin previously. He had never had toxoid injections, to his knowledge. His only allergic history was that he had had hives once following
(41) Penicillamine dermopathy
Authors: I.H. Coulson, R.A. Marsden
Journal: British Journal of Dermatology (1985)

Journal Article (41) Penicillamine dermopathy Get access I.H. Coulson, I.H. Coulson St George's Hospital, London SW17 Search for other works by this author on: Oxford Academic Google Scholar R.A. Marsden R.A. Marsden St George's Hospital, London SW17 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Pages 87–88, https://doi.org/10.1111/j.1365-2133.1985.tb13056.x Published: 01 July 1985
Dyspnea and Heart Failure in the Emergency Department—Reply
Authors: Najib T. Ayas, Charlie S. Wang, J. Mark FitzGerald
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vascular Endothelial Growth Factor Tightly Regulates In Vivo Development of Murine Hepatocellular Carcinoma Cells
Authors: Hitoshi Yoshiji, Shigeki Kuriyama, Junichi Yoshii, Masaharu Yamazaki, Masaji Kikukawa, Hirohisa Tsujinoue, Toshiya Nakatani, Hiroshi Fukui
Journal: Hepatology (1998)

Angiogenesis is essential for the development of a solid tumor, including hepatocellular carcinoma (HCC). HCC is a well-known hypervascular tumor. Vascular endothelial growth factor (VEGF) is one of the most potent angiogenic factors. Its role has not been clarified in vivo in HCC development. We used a self-contained, tetracycline-regulated retroviral vector system to elucidate the effect of VEGF on murine HCC development in a xenograft experimental model. By delivering the VEGF gene within the retroviral vector and under the control of a tetracycline-regulated promoter, we were able to manipulate VEGF expression in vivo tumor by providing tetracycline in the drinking water. Overexpression of VEGF showed a marked increase in tumor development accompanied by augmentation of neovascularization. The degree of tumor enlargement corresponded to the level of VEGF gene expression. Suppression of VEGF led to a decrease in tumor growth at the established tumor size, whether relatively small or large. The level of VEGF expression did not alter the proliferation of HCC cells in vitro. In a double-chamber chemoinvasion assay, the in vitro invasion activity of VEGF-transduced cells was not changed. In the presence of endothelial cells (EC), however, VEGF-transduced cells showed a marked increase in their in vitro invasion activity. These results suggested that VEGF plays a critical role in the development of HCC in cooperation with EC
Hazards of Ethacrynic Acid
Authors: John P. Merrill
Journal: JAMA (1970)

<h3>To the Editor.—</h3> I agree that in a patient who may already have volume depletion additional fluid depletion following the administration of a diuretic may further compromise the marginally functional kidneys. However, in my communication I pointed out that obviously adequate hydration should be first achieved. In addition to this, if one is using a so-called loop diuretic to determine whether or not the oliguria would respond, I am sure that careful observation of the urine volume would be in order for this reason, and thus, it is highly unlikely that the patients would have fluid depletion before adequate replenishment could be given. I agree that the possibility of deafness associated with ethacrynic acid and the presence of azotemia is a potential hazard. However, in using this technique for more than three years, we have seen only three cases of transient deafness and never one of permanent deafness. In the
Intrauterine growth retardation and umbilical artery flow: Authors' Reply
Authors: G. Burke, B. Stuart, P. Crowley, S. N. Scanaill, J. Drumm
Journal: BMJ (1990)

renew the plasticine lining and repeat the procedure until one is confident in the mechanics of the resectoscope.We have used this model regularly at our gynaecological endoscopy workshops and the response of trainees has been universally positive.With minor modifications, urologists in training and others who use a resectoscope within a cavity may also find it a useful aid for endoscopic procedures.
Serum eosinophil cationic protein (ECP): reference values in healthy nonatopic children
Authors: P.S. Fitch, V. Brown, B.C. Schock, M. Ennis, M.D. Shields, R. Taylor
Journal: Allergy (1999)

Background: Although serum ECP concentrations have been reported in normal children, there are currently no published upper cutoff reference limits for serum ECP in normal, nonatopic, nonasthmatic children aged 1–15 years. Methods: We recruited 123 nonatopic, nonasthmatic normal children attending the Royal Belfast Hospital for Sick Children for elective surgery and measured serum ECP concentrations. The effects of age and exposure to environmental tobacco smoke (ETS) on the upper reference limits were studied by multiple regression and fractional polynomials. Results: The median serum ECP concentration was 6.5 μg/l and the 95th and 97.5th percentiles were 18.8 and 19.9 μg/l. The median and 95th percentile did not vary with age. Exposure to ETS was not associated with altered serum ECP concentrations ( P =0.14). Conclusions: The 95th and 97.5th percentiles for serum ECP for normal, nonatopic, nonasthmatic children (aged 1–15 years) were 19 and 20 μg/l, respectively. Age and exposure to parental ETS did not significantly alter serum ECP concentrations or the normal upper reference limits. Our data provide cutoff upper reference limits for normal children for use of serum ECP in a clinical or research setting.
Long-Term Outcomes of Neointimal Hyperplasia Without Neoatherosclerosis After Drug-Eluting Stent Implantation
Authors: Jung-Sun Kim, Jung-Hee Lee, Dong-Ho Shin, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Yangsoo Jang, Myeong-Ki Hong
Journal: JACC. Cardiovascular imaging (2014)
G‐6‐PD Walter Reed: Possible insight into “structural” NADP in G‐6‐PD
Authors: Ernest Beutler, Kip Hartman, Terri Gelbart, Linda Forman
Journal: American Journal of Hematology (1986)

Abstract A new Gd‐PD variant, Gd‐PD Walter Reed, causing hereditary nonspherocytic hemolytic anemia is characterized. This variant is unusual in that its stability requires the presence of high concentrations of NADP, while its Km for NADP is normal. This finding is consistent with the suggestion that Gd‐PD has two separate binding sites, a high affinity “structural” site and a lower affinity catalytic site. The mutation in G‐6‐PD Walter Reed, like that of the previously described variant, G‐6‐PD Torrance, may be due to a mutation of the “structural” site for NADP.
THE DEVELOPMENT OF PURE CULTURES OF FIBROBLASTS FROM SINGLE MONONUCLEAR CELLS
Authors: Johannes K. Moen
Journal: The Journal of Experimental Medicine (1935)

1. Most isolated guinea pig mononuclear exudative cells in tissue culture become typical migrating macrophages, but a small proportion take on fibroblastic characteristics, and produce pure colonies of fibroblasts. These fibroblasts maintain their morphological characteristics through repeated subcultures. 2. It is suggested that the subsequent development of individual mononuclear cells in tissue culture is conditioned at the time of explantation. 3. Apposition with other cells is not necessary for the initiation of mitotic cellular division. 4. There is a definite optimal relationship between the bulk of the medium, the number of explanted cells and the extent of proliferation. The presence of other cells in the vicinity enhances cellular division. 5. Mitosis in the isolated explanted cell is preceded by a latent period. The rate of division varies in different colonies of fibroblasts. 6. Admixed erythrocytes in the mononuclear suspension definitely inhibit proliferation of fibroblasts in tissue culture. The inhibiting factor in disintegrating erythrocytes is apparently present in the stroma.
Inflammatory myofibroblastic tumor as adverse outcome of eosinophilic esophagitis
Authors: M. Fassan, C. Castoro, A. Saenz, M. Cagol, V. Ninfo, M. Rugge
Journal: Endoscopy (2009)

An emergency esophagogastroduodenoscopy performed in a dyspeptic 19-year-old girl with hematemesis, abdominal pain, and anemia ([Fig. 1]) revealed a polypoid esophageal mass with distal erosion. A subsequent CT scan confirmed the bulky lesion (14 × 4 × 3.5 cm) extending from the carina to the cardia level. Both extraesophageal extension and nodal and extranodal metastases were excluded. The extent and location of the mass ruled out any endoscopic resection and a total esophagectomy with gastric pull-up was performed. Both histology and immunophenotyping (positive for vimentin, MNF116, and smooth muscle actin; negative for S100 and CD117) were consistent with the “classical variant” of inflammatory myofibroblastic tumor (IMT). A prominent eosinophilic infiltrate ([Fig. 2 a – c]) was also present, spreading from the lesional to the extralesional area, where the squamous epithelium featured rich eosinophic infiltrate, fully consistent with eosinophilic esophagitis ([Fig. 2 d]).
Chronic Burkholderia cepacia bronchiectasis in a non-cystic fibrosis individual
Authors: M J Ledson, M J Gallagher, M J Walshaw
Journal: Thorax (1998)

Infection with Burkholderia cepacia due to social contact is well described in patients with cystic fibrosis. However, social transmission to non-cystic fibrosis individuals or chronic colonisation in non-cystic fibrosis individuals has not been described. A report of B cepacia bronchiectasis is presented where a previously healthy mother of two cystic fibrosis children colonised with B cepacia became infected by the same epidemic strain. The implications of this for parents, siblings, and partners of individuals with cystic fibrosis are discussed.
Epidemiology and clinical management of meningococcal disease in west gloucestershire: retrospective, population based study
Authors: P. A. Wylie, D. Stevens, W. D. III, J. Stuart, K. Cartwright
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objective:</b> To study changes in the epidemiology and management of meningococcal disease in one health district during a period of high local incidence of disease. <b>Design:</b> Prospective case ascertainment and data collection over 14 years, with retrospective analysis of cases. <b>Setting:</b> West Gloucestershire (population 320 000). <b>Subjects:</b> Residents developing meningococcal disease between 1 January 1982 and 31 December 1995. <b>Results:</b> 252 cases of invasive meningococcal disease were identified, of which 102 (40%) were officially notified and 191 (76%) were confirmed by culture from a deep site. The observed disease incidence of 5.6/100 000/year was about 2.7 times the national incidence (as measured by either statutory notifications or reference laboratory reports). The period 1983–90 was characterised by a prolonged localised outbreak due to serogroup B serotype 15 sulphonamide resistant (B15R) strains. General practitioners gave benzylpenicillin before hospital admission to 18% of patients who presented with meningococcal disease in the first half of the study period and to 40% who presented in the second half. The overall case fatality rate was 6.7% (17/252). Four deaths were directly or indirectly related to lumbar puncture. Of 120 patients whose lumbar puncture yielded meningococci, nine (8%) showed no abnormality on initial examination. <b>Conclusions:</b> Neither laboratory records nor formal notifications alone can give an accurate estimate of the incidence of meningococcal disease. Because of the dangers of lumbar puncture, the frequency of misleading negative initial findings, and the advent of new diagnostic techniques, the need for samples of cerebrospinal fluid should be critically questioned in each case of suspected meningococcal disease. <h3>Key messages</h3> The first doctor to suspect a diagnosis of meningococcal disease should start treatment immediately Education and encouragement can increase the proportion of patients with meningococcal disease receiving benzylpenicillin before admission to hospital Specimens for polymerase chain reaction testing should be collected from all patients suspected of having meningococcal disease in admission to hospital The need for lumbar puncture should be considered carefully in suspected meningococcal meningitis; it is contraindicated in meningococcal septicaemia Notifications of meningococcal disease remain incomplete; accurate estimation of numbers of cases requires reconciliation of notifications with laboratory diagnoses and local clinical registers
Analysis of cross‐reactive allergens from American and German cockroaches by human IgE
Authors: C.‐H. Wu, S.‐F. Luo, D. W. Wong
Journal: Allergy (1997)

Serum from atopics hypersensitive to the American cockroach were examined for their specific IgE to American and German cockroaches by the fluoroallergosorbent test (FAST). Of 44 sera tested, 86.4% (38/44) contained IgE to American and German cockroaches, and 13.6% (6/44) were found to be positive for American cockroach alone by FAST. Nine individual sera containing IgE antibodies to both cockroaches were used to analyze the cross‐reacting allergens in the crude American and German cockroach extracts by FAST inhibition and immunoblotting. FAST‐inhibition studies showed various degrees but similar inhibition of binding of human IgE to solid‐phase American cockroach extract. Proteins from both cockroach extracts were separated on SDS‐PAGE followed by immunoblotting, and the results showed considerable heterogeneity in the IgE‐binding patterns with each of the cockroach extracts for the same nine individual sera. Components with apparent molecular weights of 60, 52, 49, 38, and 12 kDa from both the American and German cockroaches were able to bind IgE antibody. These results suggest the presence of cross‐reactive allergens in the American and the German cockroaches.
Percutaneous transhepatic endoscopic holmium laser lithotripsy for intrahepatic and choledochal biliary stones
Authors: Anna Maria Ierardi, Federico Fontana, Mario Petrillo, Chiara Floridi, Eugenio Cocozza, Sergio Segato, Hatem Abou El Abbas, Alberto Mangano, Gianpaolo Carrafiello, Renzo Dionigi
Journal: International Journal of Surgery (2013)
ACTIVE IMMUNIZATION OF GUINEA PIGS WITH THE VIRUS OF EQUINE ENCEPHALOMYELITIS
Authors: Herald R. Cox, Peter K. Olitsky
Journal: The Journal of Experimental Medicine (1936)

From a study by quantitative methods, the conclusion is reached that a resistance of high degree may be induced in guinea pigs and mice against experimental equine encephalomyelitis by means of formolized vaccines in which no active virus can be demonstrated. The induced resistance is not due to residual traces of active virus which might possibly have escaped detection in the formolized tissue preparations.
CHARACTERIZING CHRONIC MYOCARDIAL INFARCTIONS IN PATIENTS USING NATIVE T1-BASED CARDIOVASCULAR MAGNETIC RESONANCE
Authors: Avinash Kali, Eui-Young Choi, Behzad Sharif, Young Jin Kim, Xiaoming Bi, Bruce Spottiswoode, Ivan Cokic, Hsin-Jung Yang, Mourad Tighiouart, Debiao Li, Daniel Berman, Byoung Wook Choi, Hyuk-Jae Chang, Rohan Dharmakumar
Journal: Journal of the American College of Cardiology (2015)
Gastric gland metaplasia in the small and large intestine.
Authors: I Yokoyama, S Kozuka, K Ito, K Kubota, Y Yokoyama
Journal: Gut (1977)

Fifty-six surgical specimens with various ulcerative intestinal disorders were microscopically investigated for evidence of gastric gland metaplasia. Thiry-one specimens (55-4%) showed pyloric gland metaplasia. Among the 31 patients with pyloric gland metaplasia, five showed true gastric metaplasia, consisting of parietal cells, chief cells, and mucous neck cells. The percentage of true gastric metaplasia among pyloric gland metaplasia was as high as 16%, an overall frequency of 9% among various ulcerative intestinal disorders. The mechanism of pyloric gland metaplasia and true gastric metaplasia is not understood, but may occur secondary to submucosal response to ulcer healing and subsequent alteration of the intraluminal condition in the intestine.
Antiseptic principle in the practice of surgery.
Authors: J. Lister
Journal: BMJ (1967)

In the course of an extended investigation into the nature of inflammation, and the healthy and morbid conditions of the blood in relation to it, I arrived several years ago at the conclu sion that the essential cause of suppuration in wounds is decom position, brought about by the influence of the atmosphere upon blood or serum retained within them, and, in the case of contused wounds, upon portions of tissue destroyed by the violence of the injury. To prevent the occurrence of suppuration with all its attendant risks was an object manifestly desirable, but till lately apparently unattainable, since it seemed hopeless to attempt to exclude the oxygen, which was universally regarded as the agent by which putrefaction was effected. But when it had been shown by the researches of Pasteur that the septic property of the atmosphere ?depended not on oxygen, or any gaseous constituent, but on minute organisms suspended in it, which owed their energy to their vitality, it occurred to me that decom position in the injured part might be avoided, without excluding the air, by applying as a dressing some material capable of destroying the life of the floating particles. Upon this principle I have based a practice of which I will now attempt to give a short account.