Ehlers-Danlos Syndrome and Recurrent Hemoptysis
Authors: GEORGE A. ROBITAILLE
Journal: Annals of Internal Medicine (1964)

Case Studies1 October 1964Ehlers-Danlos Syndrome and Recurrent HemoptysisGEORGE A. ROBITAILLEGEORGE A. ROBITAILLEAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-716 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptApproximately 100 cases of Ehlers-Danlos syndrome have been reported to date, and most of these descriptions have dealt with the external manifestations of this disease. The internal manifestations have not been investigated to any significant extent.The purpose of this report is to present a case that exhibited internal abnormalities not previously reported. It describes severe hemoptysis of 4-yr duration, associated with unusual bronchial findings.CASE REPORTA 28-year-old Caucasian male was admitted to the hospital on August 12, 1963, complaining of hemoptysis and right anterior chest pain of 3 days duration. The sputum was described as being bright red...References1. EHLERS E: Cutis laxa, Neigung zu Haemorrhagien in der Haut, Lockerung mehrer Arlikulationem. Derm. Z. 8: 173, 1901. Google Scholar2. DANLOW M: Un cas de cutis laxa avec tumeurs par contusion chronique des coudes et des genoux. Bull. Soc. Franc. Derm. Syph. 19: 70, 1908. Google Scholar3. JOHNSONFALLS SAHF: Ehlers-Danlos-Syndrome: a clinical and genetic study. Arch. Derm. Syph. (Chicago) 60: 82, 1949. CrossrefMedlineGoogle Scholar4. DURHAM DG: Cutis hyperplastica (Ehlers-Danlos-Syndrome) with blue scleras, microcornea, and glaucoma. Arch. Ophthal. (Chicago) 49: 220, 1953. CrossrefMedlineGoogle Scholar5. MCKUSICK VA: Heritable Disorders of Connective Tissue, 2nd edition, C. V. Mosby & Co., St. Louis, 1960, p. 165. Google Scholar6. BROMBARTCOUPATEZLAURENT MGY: Contribution a l'etude de l'etiologie de la hernie hiatale et de la diverticulose du tube digestif: un cas de maladie d'Ehlers-Danlos associee a une hernie, un diverticule duodenal, une diverticulose colique et una anemie sideropenique. Arch. Mal. Appar. Dig. 41: 413, 1952. MedlineGoogle Scholar7. MOURNIER-KUHNMEYERS PL: Mega-organes, syndromes de Mickulicz et d'Ehlers-Danlos chez une heredosyphilitique. Bull. Soc. Med. Hop. Lyon, 1943. Google Scholar8. PACKERBLADES BDJF: Dermatorrhexis: a case report: the so-called Ehlers-Danlos syndrome. Virginia Med. Monthly 81: 21, 1954. Google Scholar9. MORTES A: An Investigation Into the Ehlers-Danlos Syndrome, Edinburgh Thesis, 1954. Google Scholar10. TUCKERMILLERJACOBY DHDEWJ: Ehlers-Danlos syndrome with a sinus of valsalva aneurysm and aortic insufficiency simulating rheumatic heart disease. Amer. J. Med. 35: 715, 1963. CrossrefMedlineGoogle Scholar11. JACOBS PH: Ehlers-Danlos syndrome: report of a case with onset at age 29. Arch. Derm. (Chicago) 76: 460, 1957. CrossrefGoogle Scholar12. ROBERTSONEDDYVASSLER JAWAAJ: Spontaneous perforation of the cecum without mechanical obstruction: review of literature and case report. Amer. J. Surg. 96: 446, 1958. CrossrefGoogle Scholar13. FREEMAN JT: Ehlers-Danlos syndrome. Amer. J. Dis. Child. 79: 1049, 1950. MedlineGoogle Scholar14. WALLOCHBERKHART EAEF: Ehlers-Danlos syndrome associated with tetralogy of fallot. Arch. Derm. Syph. 61: 750, 1950. CrossrefGoogle Scholar15. KORTINGGOTTRON GWE: Cutis laxa. Arch. Derm. Syph. (Berlin) 193: 14, 1951. CrossrefMedlineGoogle Scholar16. JANSEN LH: The structure of the connective tissue: an explanation of the symptoms of the Ehlers-Danlos syndrome. Dermatologica 110: 108, 1955. CrossrefMedlineGoogle Scholar17. MADISONBRADLEYCASTILLO WMEJAJ: Ehlers-Danlos syndrome with cardiac involvement. Amer. J. Cardiol. 11: 689, 1963. CrossrefGoogle Scholar18. VISSAINROVINSKI LJ: Syndrome d'Ehlers-Danlos chez quatre membres d'une meme famille. Bull. Soc. Franc. Derm. Syph. 62: 62, 1955. MedlineGoogle Scholar19. SAMUELSCHWARTZMEISTER MAMLMM: The Ehlers-Danlos syndrome. U. S. Armed Forces Med. J. 4: 737, 1953. MedlineGoogle Scholar20. LISKERNOGUERONSANCHEZ-MEDAL RAL: Plasma thromboplastin component deficiency in the Ehlers-Danlos syndrome. Ann. Intern. Med. 53: 388, 1960. LinkGoogle Scholar21. GOODMANLEVITSKYFRIEDMAN RMJMIA: The Ehlers-Danlos syndrome and multiple neurofibromatosis in a kindred of mixed derivation, with special emphasis on hemostasis in the Ehlers-Danlos syndrome. Amer. J. Med. 32: 976, 1962. CrossrefMedlineGoogle Scholar22. DAYZARAFONETIS HJDJ: Coagulation studies in four patients with Ehlers-Danlos syndrome, Amer. J. Med. Sci. 242: 565, 1961. MedlineGoogle Scholar23. BARRETTTUTTLE RJWM: A study of essential hemoptysis. J. Thorac. Cardiov. Surg. 40: 468, 1960. CrossrefMedlineGoogle Scholar24. GIBBON JH: Surgery of the Chest, W. B. Saunders & Co., Philadelphia, 1962, p. 361. Google Scholar25. OLSEN AM: Bronchiectasis and dextrocardia: observations on etiology of bronchiectasis. Amer. Rev. Tuberc. 47: 435, 1943. Google Scholar26. ZUCKERMANWURTZEBACH HSLR: Kartagener's triad: review of literature and report of case. Dis. Chest. 19: 92, 1951. CrossrefMedlineGoogle Scholar27. HINSHAWGARLAND HCLH: Diseases of the Chest, 2nd edition, W. B. Saunders & Co., Philadelphia, 1963, p. 189. Google Scholar28. TOBIAS N: Danlos Syndrome associated with congenital lipomatosis. Arch. Derm. Syph. (Chicago) 30: 540, 1934; Ibid., 40: 135, 1939. CrossrefGoogle Scholar29. RICKETSON G: The behavior of skin grafts and donor sites in a case of Ehlers-Danlos syndrome. Plast. Reconstr. Surg. 20: 32, 1957. CrossrefGoogle Scholar30. ROSSDOONIEF MAS: Chest surgery in the presence of cutis hyperelastica (Ehlers-Danlos syndrome). New York J. Med. 57: 2256, 1957. MedlineGoogle Scholar31. FANTLMORRISSAWERS PKNRJ: Repair of cardiac defect in patient with Ehlers-Danlos syndrome and deficiency of Hageman factor. Brit. Med. J. 1202, Apr. 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE A. ROBITAILLEFrom the Department of Medicine, United States Naval Hospital, Portsmouth, Va.Requests for reprints should be addressed to Lt. George A. Robitaille, USN (MC), U. S. Naval Hospital, Portsmouth, Va. 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WOOLEY, M.D.Bronchiektasie: KlinikSindrome de ehlers-danlos asociado a pectus carinatusAortic Insufficiency in Ehlers-Danlos SyndromeEhlers-Danlos Syndrome and Cardiovascular AbnormalitiesCardiac abnormalities in the Ehlers-Danlos syndrome.The radiology of the Ehlers-Danlos syndromeIrregular Blood CoagulationEhlers-Danlos Syndrome: A case with some skeletal changesEhlers-Danlos Syndrome Occurring Together with the Marfan SyndromeFunctional and Ultrastructural Abnormalities of Platelets in Ehlers-Danlos SyndromeHEIHACHIRO KASHIWAGI, M.D., JEANNE M. RIDDLE, PH.D., JOSEPH P. ABRAHAM, M.D., BOY FRAME, M.D., F.A.C.P. 1 October 1964Volume 61, Issue 4 Page: 716-721 Keywords Bronchiectasis Erythema Hospital medicine Ischemia Sputum ePublished: 1 December 2008 Issue Published: 1 October 1964 PDF downloadLoading ...