Soluble Glomerular Basement Membrane Antigens in Normal Urine—Possible Autoimmunogens in Man
Authors: R. A. Lerner, J. J. Mcphaul, F. J. Dixon
Journal: Annals of Internal Medicine (1968)

Editorial Notes1 January 1968Soluble Glomerular Basement Membrane Antigens in Normal Urine—Possible Autoimmunogens in ManR. A. LERNER, M.D., J. J. MCPHAUL JR., F. J. DIXON, M.D.R. A. LERNER, M.D.Search for more papers by this author, J. J. MCPHAUL JR.Search for more papers by this author, F. J. DIXON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-1-249 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has been known for some time that antiglomerular basement membrane (GBM) antibodies can cause glomerulonephritis in experimental animals but only recently has it been shown that they are pathogenetic in at least some instances of human glomerulonephritis (1-3). In this regard, the recent induction of glomerulonephritis in the monkey with human anti-GBM antibody eluted from human nephritic kidneys would appear to establish the pathogenicity of these antibodies in Goodpasture's syndrome and in some cases of rapidly advancing glomerulonephritis (3). Although the exact prevalence of antibodies directed against the glomerular basement membrane in cases of human glomerulonephritis is not known,...References1. STEBLAY RW: Glomerulonephritis induced in sheep by injection of heterologous glomerular basement membrane and Freund's complete adjuvant. J. Exp. Med. 116: 253, 1962. CrossrefMedlineGoogle Scholar2. LERNERDIXON RAFJ: Transfer of ovine experimental allergic glomerulonephritis (EAG) with serum. J. Exp. Med. 124: 431, 1966. CrossrefMedlineGoogle Scholar3. LERNERGLASSOCKDIXON RARJFJ: The role of antiglomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. J. Exp. Med. In press, December 1967. CrossrefMedlineGoogle Scholar4. HOLM SE: Precipitinogens in beta-hemolytic streptococci and some related human kidney antigens. Acta Path. Microbiol. Scand. In press. Google Scholar5. MARKOWITZLANGE ASCF: Streptococcal related glomerulonephritis. I. Isolation, immunochemistry and comparative chemistry of soluble fractions from type 12 nephritogenic streptococci and human glomeruli. J. Immun. 92: 565, 1964. MedlineGoogle Scholar6. MICHAELDRUMMONDGOODVERNIER AFKNRARL: Acute poststreptococcal glomerulonephritis: immune deposit disease. J. Clin. Invest. 45: 237, 1966. CrossrefMedlineGoogle Scholar7. ANDRESACCINNIHSUZABRISKIESEEGAL GALKCJBBC: Electron microscopic studies of human glomerulonephritis with ferritin-conjugated antibody. Localization of antigen-antibody complexes in glomerular structures of patients with acute glomerulonephritis. J. Exp. Med. 123: 399, 1966. CrossrefMedlineGoogle Scholar8. HAWKINSCOCHRANE DCG: Glomerular basement membrane damage in immunologic glomerulonephritis. Immunology. In press. Google Scholar9. MCPHAULLERNERDIXON JJRAFJ: In preparation. Google Scholar10. LERNERDIXON RAFJ: The induction of acute glomerulonephritis in rabbits by injection with soluble autologous and homologous glomerular basement membrane (GBM) antigens isolated from normal urine. In preparation. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInfektionen durch Klebsiellen 1 January 1968Volume 68, Issue 1Page: 249-250KeywordsAntibodiesAntigensBasement membraneGlomerulonephritisKidneysPathogens Issue Published: 1 January 1968 PDF downloadLoading ...