Humours, Tumors, and Caveats
Authors: SAUL W. ROSEN
Journal: Annals of Internal Medicine (1975)

Editorials1 February 1975Humours, Tumors, and CaveatsSAUL W. ROSEN, PH.D., M.D., F.A.C.P., BRUCE D. WEINTRAUB, M.D.SAUL W. ROSEN, PH.D., M.D., F.A.C.P.Search for more papers by this author, BRUCE D. WEINTRAUB, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-2-274 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPolyendocrine syndromes have been described for more than two decades. They include syndromes of endocrine deficiency as well as endocrine excess. Primary insufficiency of thyroid and adrenal cortex (the Schmidt syndrome) may be associated with additional endocrine deficits, notably diabetes mellitus or ovarian failure (1). The syndromes of polyendocrine excess fall into three main categories. In multiple endocrine adenomatosis (MEA) type I (the Wermer syndrome) hyperplasia, adenoma, or carcinoma of one or more endocrine glands is inherited as an autosomal dominant. The parathyroids, pancreatic islets, and pituitary are most commonly affected. These patients are known to have an increased incidence...References1. CARPENTER C, SOLOMON N, and SILVERBERG S: Schmidt's syndrome (thyroid and adrenal insufficiency): a review of the literature and report of fifteen new cases including ten instances of coexistent diabetes mellitus. Medicine (Baltimore) 43:153-180, 1964 MedlineGoogle Scholar2. SNYDER N, SCURRY M, and DEISS W: Five families with multiple endocrine adenomatosis. Ann Intern Med 76:53-58, 1972 LinkGoogle Scholar3. MELVIN K, TASHJIAN A, and MILLER H: Studies in familial (medullary) thyroid carcinoma. Recent Prog Horm Res 28:399-470, 1972 MedlineGoogle Scholar4. OMENN G: Pathobiology of ectopic hormone production by neoplasms in man. Pathobiol Annu 3:177-216, 1973 Google Scholar5. MANES J and TAYLOR H: Thymic carcinoid in familial multiple endocrine adenomatosis. Arch Pathol 95:252-255, 1973 MedlineGoogle Scholar6. SILVA O, BECKER K, and PRIMACK A: Ectopic secretion of calcitonin by oat-cell carcinoma. N Engl J Med 290:1122-1124, 1974 CrossrefMedlineGoogle Scholar7. ROSEN S and WEINTRAUB B: Ectopic production of the isolated alpha subunit of the glycoprotein hormones: a quantitative marker in certain cases of cancer. N Engl J Med 290:1441-1447, 1974 CrossrefMedlineGoogle Scholar8. ROSEN S, WEINTRAUB B, and VAITUKAITIS J: Placental proteins and their subunits as tumor markers. Ann Intern Med 82:71-83, 1975 LinkGoogle Scholar9. WEINTRAUB B and ROSEN S: Competitive radioassays and "specific" tumor markers. Metabolism 22:1119-1127, 1973 CrossrefMedlineGoogle Scholar10. RUOSLAHTI E and SEPPÄLÄ M: Normal and increased alpha-fetoprotein in neoplastic and non-neoplastic liver disease. Lancet 2:278, 1972 CrossrefMedlineGoogle Scholar11. HEYNEN G and FRANCHIMONT P: Human calcitonin radioimmuno-assay in normal and pathological conditions. Eur J Clin Invest 4:213-222, 1974 MedlineGoogle Scholar12. TASHJIAN A, HOWLAND B, and MELVIN K: Immunoassay of human calcitonin: clinical measurement, relation to serum calcium and studies in patients with medullary carcinoma. N Engl J Med 283:890-895, 1970 CrossrefMedlineGoogle Scholar13. DEFTOS L, POWELL D, and PARTHEMORE J: Secretion of calcitonin in hypocalcemic states in man. J Clin Invest 52:3109-3114, 1973 CrossrefMedlineGoogle Scholar14. RABSON A, ROSEN S, and TASHJIAN A: Production of human chorionic gonadotropin in vitro by a cell line derived from a carcinoma of the lung. J Natl Cancer Inst 50:669-674, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SAUL W. ROSEN, PH.D., M.D., F.A.C.P.; BRUCE D. WEINTRAUB, M.D.Affiliations: Clinical Endocrinology Branch National Institute of Arthritis, Metabolism and Digestive Diseases Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHormone production by cultures of small-cell carcinoma of the lung 1 February 1975Volume 82, Issue 2Page: 274-276KeywordsAdenomasAdrenal cortexDiabetes mellitusEndocrine adenomatosisEndocrine physiologyFallsParathyroidThyroid ePublished: 1 December 2008 Issue Published: 1 February 1975 PDF downloadLoading ...