tbuckley/cabot-search huggingface dataset:
ADENOMA SEBACEUM OF THE NON-SYMMETRICAL TYPE.
Authors: WILLIAM S. GOTTHEIL
Journal: JAMA (1901)

The pathologico-anatomical term adenoma still lacks both definiteness and circumscription. Some authorities extend it to include all increase of glandular epithelium, even when form and function are well preserved. Others limit the designation to an atypical increase with loss of function. It is not surprising, therefore, that the same confusion should exist with regard to the sebaceous adenomata of the skin. The affection is a rare one, and the opportunities for histological examination have not been numerous. A study of the literature, however, shows very plainly that two main pathological types may be distinguished. The first accords with Unna's definition: Benign, irregular, tumorous outgrowths of the sebaceous epithelium, going on to fatty, but not to corneous or colloid metamorphosis. The second is a simple hypertrophy of apparently normal sebaceous gland tissue. Clinically, also, at least two types of sebaceous adenomata are to be recognized; they do not, however, correspond to
Effect of verapamil in infants with paroxysmal supraventricular tachycardia.
Authors: J Soler-Soler, J Sagristá-Sauleda, A Cabrera, J Sauleda-Parés, J Iglesias-Berengué, G Permanyer-Miralda, J Roca-Llop
Journal: Circulation (1979)

Twenty-nine consecutive spontaneous attacks of paroxysmal supraventricular tachycardia (PSVT) in 14 infants (mean age 4.4 months) were treated with verapamil. No infant had associated heart disease. Verapamil 1-2 mg i.v was administered over 30 seconds. The dosage varied according to the weight of the infant. Within 60 seconds sinus rhythm was obtained in 28 instances (96.5%). No significant complications were observed. The high effectiveness, rapid action and lack of undesirable side effects observed in this series suggest that verapamil is the drug of choice in the treatment of PSVT in infants without underlying heart disease.
Computed Tomography of the Whole Body
Authors: Bruce Silver
Journal: JAMA (1990)

There have been dramatic changes in diagnostic imaging over the last few years. Computed tomography (CT) has been challenged by magnetic resonance imaging (MRI) and ultrasound. Although MRI has established its place in neuroradiology, its role in the abdomen is less clearly defined. Ultrasound remains complementary to CT in its evaluation. In trauma, CT remains the modality of choice. Currently, CT scanners outnumber magnetic resonance installations, and CT examinations generally cost less than MRI. Computed tomography remains a viable imaging technique. Subsequently, a text dedicated to CT of the body will continue to have considerable value for diagnostic radiologists. The second edition of this already well-received text has undergone several changes. Most noticeable are several new chapters in the first volume dealing with neurological CT. These include chapters on hydrocephalus and cerebral atrophy, intracranial calcifications, and demyelinating diseases. The chapter on CT of the spine has been rewritten, and that
Priming of T helper cells by antigen-activated B cells. B cell-primed Lyt-1+ helper cells are restricted to cooperate with B cells expressing the IgvH phenotype of the priming B cells.
Authors: J L'Age-Stehr
Journal: The Journal of Experimental Medicine (1981)

Activated B cells isolated shortly after primary immunization of BALB/c donor mice with sheep erythrocytes (SRBC), were transferred to normal syngeneic recipients or to low-dose cyclophosphamide-pretreated syngeneic recipients. In pretreated recipients, the transfer of activated B cells, but not of T cells or macrophages, resulted in an augmented production of indirect plaque-forming cells in the primary immune response to SRBC but not to horse erythrocytes. It was shown in double-transfer experiments that T helper cells (Lyt-1+) had been stimulated by the transfer of antigen-activated B cells. Criss-cross double-transfer experiments using the mouse strains CB20 and BAB14 (congenic to BALB/c at the loci coding for the immunoglobulin heavy chain) indicate that those T helper cells are primed after recognition of B cell products that are encoded for by genes linked to the loci coding for the variable region of the immunoglobulin heavy chain (IgVH). The thus-primed Ig-dependent T helper cells (THIg) are adaptively restricted to cooperate with B cells that display IgVH-linked gene products similar to those that originally stimulated the THIg. These findings suggest that in the course of an immune response to T cell-dependent antigens, help for the production of specific IgG can be provided by THIg that have been primed and/or clonally expanded after recognition of IgVH-linked gene products by (e.g., complementary) T cell receptors.
CYR61 Expression Promotes Taxol Resistance: A Molecular Link with the p53 in Breast.
Authors: I. Espinoza, R. Lupu
Journal: Cancer Research (2009)

Abstract CYR61 render human breast cancer cells highly resistance to the microtubule-interfering agent Taxol, a drug of choice for the treatment of metastatic breast cancer. The angiogenic factor CYR61 and its receptor avβ3 are markedly up-regulated in very aggressive breast carcinomas. Integrin signaling has been shown to modulate cancer cell responses to chemotherapy agents. Thus, the signal transduction pathways initiated by integrin may be a potential target for inhibiting cell survival during cytotoxic drug exposure. However, the molecular mechanism for CYR61-induces cytoprotection still unknown. Our data demonstrates that functional blockade of avβ3 with a synthetic chemical peptidomimetic based upon the αvβ3 the RGD (Arg-Gly-Asp) motif, is specifically cytotoxic towards CYR61-overexpressing breast cancer cells and that pharmacological interference of the CYR61/αvβ3 interaction restores Taxol efficacy. This data suggests that a previously unrecognized CYR61/αvβ3-driven cellular signaling actively modulates cell growth, apoptosis and chemosensitivity. To better understand the mechanism by which CYR61 induces Taxol resistance, we studied a series of molecular events and reveal that CYR61 prevents Taxol induction of p53 accumulation, blocks p21WAF1/CIP1 overexpression, and furthermore we demonstrated that CYR61 induces JNK activation. These observations suggest that increased expression of CYR61 could promote a chemoresistance by suppressing a specific pro-apoptotic signaling while still given chemotherapeutic treatments to induce cell damage. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 1139.
Predictive Value of the Electrocardiogram in Acute Coronary Syndromes
Authors: N. A. Mark Estes III
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elemental diet in the treatment of orofacial Crohn's disease
Authors: E A B Cameron
Journal: Gut (2002)

A 12 year old boy presented via his orthodontist with a three month history of facial swelling and a one year history of intermittent diarrhoea. Examination revealed a pale boy with asymmetrical thickening of his cheeks, a buccal mucosal fold on the left, and friable mucosa on the right. Investigations revealed a mild hypochromic microcytic anaemia and raised inflammatory markers.

An oral biopsy showed occasional granulomata and a mixed inflammatory infiltrate with negative fungal stains consistent with a diagnosis of orofacial granulomatosis. 99Tcm-HMPAO leucocyte scintigraphy showed grade 3 white cell activity in the terminal ileum …
881-2 The ability of a dobutamine stress contrast enhanced echocardiogram to improve the detection of coronary artery disease: Results from the CADET pilot study
Authors: Thomas R Porter, Arthur J Labovitz, Michael H Picard, Bruno Cotter, Edward L O'Leary, Harald Becher, Anna C McGrain, Anthony N DeMaria, Feng Xie
Journal: Journal of the American College of Cardiology (2004)
Influence of adenosine on the stimulatory effect of isoprenaline and insulin on myocardial contractility in vivo
Authors: W. R Law, P. J Carney, M. P McLane
Journal: Cardiovascular Research (1991)

Journal Article Influence of adenosine on the stimulatory effect of isoprenaline and insulin on myocardial contractility in vivo Get access William R Law, William R Law Departments of Surgery and Physiology, Loyola Univerity, Stritch School of Medicine, Maywood, IL, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Pamela J Carney, Pamela J Carney Departments of Surgery and Physiology, Loyola Univerity, Stritch School of Medicine, Maywood, IL, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael P McLane Michael P McLane Departments of Surgery and Physiology, Loyola Univerity, Stritch School of Medicine, Maywood, IL, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 25, Issue 2, February 1991, Pages 151–157, https://doi.org/10.1093/cvr/25.2.151 Published: 01 February 1991 Article history Received: 18 May 1990 Accepted: 16 October 1990 Published: 01 February 1991
Supramolecular Hydrogels for Long‐Term Bioengineered Stem Cell Therapy
Authors: Junseok Yeom, Su Jin Kim, Hyuntae Jung, Hong Namkoong, Jeonga Yang, Byung Woo Hwang, Kyunghoon Oh, Kimoon Kim, Young Chul Sung, Sei Kwang Hahn
Journal: Advanced Healthcare Materials (2014)

Synthetic hydrogels have been extensively investigated as artificial extracellular matrices (ECMs) for tissue engineering in vitro and in vivo. Crucial challenges for such hydrogels are sustaining long‐term cytocompatible encapsulation and providing appropriate cues at the right place and time for spatio‐temporal control of the cells. Here, in situ supramolecularly assembled and modularly modified hydrogels for long‐term engineered mesenchymal stem cell (eMSC) therapy are reported using cucurbit[6]uril‐conjugated hyaluronic acid (CB[6]‐HA), diaminohexane conjugated HA (DAH‐HA), and drug‐conjugated CB[6] (drug‐CB[6]). The eMSCs producing enhanced green fluorescence protein (EGFP) remain alive and emit the fluorescence within CB[6]/DAH‐HA hydrogels in mice for more than 60 d. Furthermore, the long‐term expression of mutant interleukin‐12 (IL‐12M) by eMSCs within the supramolecular hydrogels results in effective inhibition of tumor growth with a significantly enhanced survival rate. Taken together, these findings confirm the feasibility of supramolecular HA hydrogels as 3D artificial ECMs for cell therapies and tissue engineering applications.
Restoration of Kidney Function by Splenorenal Arterial Anastomosis
Authors: Kelly M. Berkley
Journal: New England Journal of Medicine (1961)

WHETHER or not a kidney with renal-artery occlusion would function after restoration of its major blood supply has not been known. Experimentally, Page,1 using the dog, was able to ligate the renal artery without producing kidney necrosis. Clinically, others2 3 4 have demonstrated that kidney dysfunction due to incomplete occlusion of the renal artery can be significantly improved by suitable vascular procedures, which increase its blood supply.If the kidney with occluded renal artery remains viable through collateral circulation, relieving the obstruction should restore its function. Time did not allow this hypothesis to be tested in the laboratory before an attempt to . . .
ALBUMINURIA IN NEPHRITIS AND BRIGHT'S DISEASE.
Authors: ALFRED STENGEL
Journal: JAMA (1906)

Nicholas Cotungo, in the latter part of the eighteenth century, called attention to the coagulable quality of the urine in cases of dropsy, and Richard Bright showed the relation of disease of the kidney to dropsy and albuminuria in the early part of the succeeding century. Subsequently the pathologic observations of Bright, of Rayer and of others seemed to establish the invariable association of these conditions. Pathologists of the new school of cellular pathology confirmed the relationship of albuminuria and dropsy with an inflammatory lesion of the kidney so that in the course of time "albuminuria" and "nephritis" became terms of nearly identical practical significance. As time went on, however, some of the physiologic chemists found that transient albuminuria or cyclical albuminuria might occur without any evidence of lasting disease of the kidneys. In the ordinary course of practice, however, physicians have looked on albuminuria as significant of nephritis, unless
Prevalence of Eating Disorders in Italy: A Survey on a Sample of 16-Year-Old Female Students
Authors: Paolo Santonastaso, Tatiana Zanetti, Alessandra Sala, Gerardo Favaretto, Giulio Vidotto, Angela Favaro
Journal: Psychotherapy and Psychosomatics (1996)

To date, the number of epidemiological studies on eating disorders (ED) in Italy and in other Mediterranean countries is still limited. This study evaluated the eating attitudes and the prevalence of eating disorders in a sample of 359 16-year-old Italian schoolgirls.The study followed a two-stage procedure consisting in a first screening stage followed by clinical interviews. A third stage consisting in a case register study and a 1-year followup confirmed the importance of evaluating subjects who chose not to participate in the survey.Prevalence rates found in our sample are consistent with those of other prevalence studies conducted on adolescent girls: 0% for anorexia nervosa, 0.5% for bulimia nervosa and 3.7% for ED not otherwise specified. Also some important features associated with the presence of an ED appeared to be present in Italian female students, as in Anglo-Saxon populations: the tendency towards denial that led to an overrepresentation of ED among nonrespondents, and the ascertainment that just a small proportion of people seeks help for ED. The Italian sample reported higher scores on eating attitudes test compared to Anglo-Saxon samples.No evidence of different rates of ED was found in our Italian sample in comparison with non-Mediterranean samples. The importance of using a two-stage design and a third control stage in prevalence studies is emphasized by our findings.
Absorption of Effervescent Aspirin during Migraine
Authors: G. N. Volans
Journal: BMJ (1974)

The absorption of effervescent aspirin was studied in 42 patients during acute attacks of migraine. When compared with normal controls and with themselves between attacks 19 out of the 42 patients showed impairment of absorption. Impairment of absorption seemed to correlate with the severity of the headache and the gastro-intestinal symptoms at the time of treatment but not with the duration of the attack or with the type of migraine. This study probably underestimated the prevalence of impairment of absorption in migraine attacks, and it is concluded that the treatment of acute migraine symptoms by oral drugs should use those formulations which are rapidly absorbed under normal conditions.
Sport for tall.
Authors: T Khosla
Journal: BMJ (1983)

Eight new events (handball, basketball, and six rowing events) were introduced for women in the Olympic Games at Montreal in 1976. Of 187 women rowers who competed at Montreal, none was shorter than the mean height (162 cm, 64 in) of women aged 18-24 in the United States. In team events only two out of 250 participants were shorter than the reference mean. Even among the tall, it was the taller participants who won medals. What does the slogan "Sport for All" mean in this context? Moreover, the physical size required of champion rowers and basketball players is not to be found in some Asian, African, and Latin American populations. International contests in many such events therefore seem to be at variance with the first charter of the Olympic Games. An independent reviewing body is urgently needed to examine the merits of man made rules in many sporting contests.
Endoscopic submucosal dissection for sessile, nonampullary duodenal adenomas
Authors: J. Jung, K. Choi, J. Ahn, J. Lee, H.-Y. Jung, K.-S. Choi, G. Lee, H. Song, D. Kim, M.-Y. Kim, S. Bae, J.-H. Kim
Journal: Endoscopy (2013)

Although endoscopic submucosal dissection (ESD) is increasingly utilized to treat early neoplasms of the gastrointestinal tract, its use for duodenal neoplasms is limited by the thin wall and narrow lumen of the duodenum. We have reviewed cases where ESD was used to treat sessile, nonampullary duodenal neoplasms. To do this, we retrospectively reviewed the medical records of patients treated with ESD for adenomas of the duodenum from January 2001 to December 2010, assessing the curative outcomes and complication rates. A total of 14 cases were reviewed. Mean patient age was 56.4 years. The mean size of tumors and mean size of the specimens were 17.1 mm and 26.4 mm, respectively. The en bloc resection rate with ESD was 78.6 %, and the complete (R<sub>0</sub>) resection rate was 85.7 %. No patient in the study experienced major bleeding. However, second-look endoscopy revealed minor bleeding requiring endoscopic homeostasis in one case (7.1 %). Perforations were observed in five cases (35.7 %). Two of the five patients with perforation underwent surgery. The ESD methods yielded acceptable curative resection rates for duodenal adenomas, although ESD was associated with a higher rate of perforation. Therefore, duodenal ESD should be performed with care and only in selected patients to avoid serious complications.
miR-205 Exerts Tumor-Suppressive Functions in Human Prostate through Down-regulation of Protein Kinase Cε
Authors: Paolo Gandellini, Marco Folini, Nicole Longoni, Marzia Pennati, Mara Binda, Maurizio Colecchia, Roberto Salvioni, Rosanna Supino, Roberta Moretti, Patrizia Limonta, Riccardo Valdagni, Maria Grazia Daidone, Nadia Zaffaroni
Journal: Cancer Research (2009)

Abstract Limited information is available concerning the expression and role of microRNAs in prostate cancer. In this study, we investigated the involvement of miR-205 in prostate carcinogenesis. Significantly lower miR-205 expression levels were found in cancer than in normal prostate cell lines as well as in tumor compared with matched normal prostate tissues, with a particularly pronounced reduction in carcinomas from patients with local-regionally disseminated disease. Restoring the expression of miR-205 in prostate cancer cells resulted in cell rearrangements consistent with a mesenchymal-to-epithelial transition, such as up-regulation of E-cadherin and reduction of cell locomotion and invasion, and in the down-regulation of several oncogenes known to be involved in disease progression (i.e., interleukin 6, caveolin-1, EZH2). Our evidence suggests that these events are driven by the concurrent repression of specific predicted miR-205 targets, namely N-chimaerin, ErbB3, E2F1, E2F5, ZEB2, and protein kinase Cε. Strikingly, the latter seemed to play a direct role in regulating epithelial-to-mesenchymal transition. In fact, its down-regulation led to a cell phenotype largely reminiscent of that of cells ectopically expressing miR-205. Overall, we showed for the first time that miR-205 exerts a tumor-suppressive effect in human prostate by counteracting epithelial-to-mesenchymal transition and reducing cell migration/invasion, at least in part through the down-regulation of protein kinase Cε. [Cancer Res 2009;69(6):2287–95]
TCT-98 All set after complete revascularization? Long term outcome of patients with complete revascularization
Authors: Jeehoon Kang, Kyung Woo Park, Si-Hyuck Kang, Hae-Young Lee, Hyun-Jae Kang, Bon-Kwon Koo, Inho Chae, Tae-Jin Youn, Hyo-Soo Kim
Journal: Journal of the American College of Cardiology (2014)
Axillary hyperhidrosis treated with alcoholic solution of aluminium chloride hexahydrate.
Authors: K T Scholes, K D Crow, J P Ellis, R R Harman, E M Saihan
Journal: BMJ (1978)

Sixty-five patients with axillary hyperhidrosis took part in a trial of treatment with a solution of 20% aluminium chloride hexahydrate in absolute alcohol, applied topically each night for a week and then whenever the patient thought it necessary. Excellent control of sweating was achieved in 64 patients, and occlusion of the area was found to be unnecessary. No troublesome side effects were reported. The results of this study indicate that 20% aluminium chloride hexahydrate in absolute alcohol is the treatment of first choice for patients with axillary hyperhidrosis.
Role of fasting gastrointestinal motility in the variability of gastrointestinal transit time assessed by hydrogen breath test.
Authors: C Di Lorenzo, C P Dooley, J E Valenzuela
Journal: Gut (1991)

Gastrointestinal motility and transit time, measured by the hydrogen breath test, were simultaneously assessed in six healthy volunteers. Each subject underwent six studies on separate days. On each day motility was measured in the gastric antrum, duodenum, and proximal jejunum and 15 g of lactulose was given either by mouth during gastric phases I, II, III of the motor migrating complex or infused duodenally during duodenal phases I, II, III, one phase being studied each day in random order. Fasting activity was not interrupted by the lactulose. The lactulose transit time decreased significantly from a peak with phase I through phase II to a minimum with phase III (mean (SD) 155 (26) min v 120 (10) min v 94 (14) min, p less than 0.001). Similar results were noted when the lactulose was instilled intraduodenally (156 (23) min v 125 (19) min v 100 (17) min, p less than 0.001). No correlation was found between motility index and transit. These results suggest that different phases of fasting gastrointestinal motility are major determinants of the transit time estimated by the hydrogen breath test and explain the variability of this test in practice.
Increased Gastric pH and the Bioavailability of Fluconazole and Ketoconazole
Authors: Robert A. Blum, David T. D'Andrea, Becky M. Florentino, John H. Wilton, Donald M. Hilligoss, Mark J. Gardner, Eugenia B. Henry, Harvey Goldstein, Jerome J. Schentag
Journal: Annals of Internal Medicine (1991)

ExcerptTwo orally active antifungal agents are currently available, ketoconazole and fluconazole. However, the absorption of ketoconazole depends on gastric pH for tablet disintegration and dissolution (1, 2). Reduced serum concentrations of ketoconazole have been reported in patients with achlorhydria and in patients receiving concomitant treatment with antacids or cimetidine (1-3). Our study was done to determine the effects of cimetidine-induced increases in gastric pH on the relative bioavailability of fluconazole and ketoconazole.MethodsTwenty-four healthy male volunteers, 19 to 43 years of age, gave written informed consent to participate in the study. The study protocol was approved by the...