tbuckley/cabot-search huggingface dataset:
Measurement of Waist Circumference
Authors: Wen-Ya Ma, Chung-Yi Yang, Shyang-Rong Shih, Hong-Jen Hsieh, Chi Sheng Hung, Fu-Chun Chiu, Mao-Shin Lin, Pi-Hua Liu, Cyue-Huei Hua, Yenh-Chen Hsein, Lee-Ming Chuang, Jou-Wei Lin, Jung-Nan Wei, Hung-Yuan Li
Journal: Diabetes Care (2012)

Waist circumference (WC) is used to define central obesity. This study aimed to compare the performance of two recommended locations of WC measurement.A cohort of 1,898 subjects who were without diabetes from 2006 to 2012 were followed for a median of 31 months (Taiwan Lifestyle Study). The WC-IC, recommended by the National Cholesterol Education Program Third Adult Treatment Panel, was measured at the superior border of the iliac crest, and the WC-mid, recommended by World Health Organization and International Diabetes Federation, was measured midway between the lowest ribs and the iliac crest. The abdominal subcutaneous fat area (SFA) and visceral fat area (VFA) were assessed by computed tomography.There was greater difference between WC-IC and WC-mid measurements in women than in men (P < 0.001). Both WC-IC and WC-mid correlated significantly with BMI, VFA, and SFA (all P < 0.001). WC-mid was better correlated to VFA than WC-IC, particularly in women, and it correlated more strongly to blood pressure, plasma glucose, hemoglobin A1c, triglyceride levels, HDL cholesterol, and C-reactive protein (all P < 0.05). The association of WC-mid with hypertension, diabetes, and metabolic syndrome was slightly better than that of WC-IC (area under the receiver operator curve 0.7 vs. 0.69, 0.71 vs. 0.68, and 0.75 vs. 0.7, respectively; all age-adjusted P < 0.05). With 90 cm (male)/80 cm (female) as criteria for central obesity, WC-mid, but not WC-IC, predicted the incidence of diabetes development (age-adjusted P = 0.003).WC-mid is a better measurement to define central obesity than WC-IC, particularly in women.
Periodic hypokalaemic paralysis, adrenal adenoma, and normal colonic transport of sodium and potassium
Authors: P. Richards, M. B. S. Jones, W. S. Peart
Journal: Gut (1973)

A 47-year-old woman was cured of hypokalaemia and recurrent paralysis by the excision of an adrenal adenoma. Hypertension was initially ameliorated but was not cured. Suppression of plasma renin activity was abolished when the adenoma was excised. Repeated measurement of plasma corticosteroids before operation showed a slight increase in aldosterone and normal plasma concentrations of deoxycorticosterone, corticosterone, and cortisol. No evidence of excess mineralocorticoid was obtained from measurement of the electrolyte composition of colonic fluid or of rectal potential difference, although both these variables responded normally to salt depletion and exogenous aldosterone. The diagnostic importance of the paradoxically normal colonic measurements is emphasized and the possibility is considered that the adenoma may have secreted an unidentified hormone.
Persistently Perplexing Purpuras: Thrombotic Thrombocytopenic Purpura and Immune Thrombocytopenic Purpura
Authors: Richard S. Stein
Journal: Annals of Internal Medicine (1994)

Letters1 November 1994Persistently Perplexing Purpuras: Thrombotic Thrombocytopenic Purpura and Immune Thrombocytopenic PurpuraRichard S. Stein, MD and John M. Flexner, MDRichard S. Stein, MDSearch for more papers by this author and John M. Flexner, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-9-199411010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We read with interest Olenich and Schattner's report [1] on postpartum thrombotic thrombocytopenic purpura (TTP) complicating immune thrombocytopenic purpura (ITP) of pregnancy and agree wholeheartedly with their emphasis on examining the peripheral smear in cases of thrombocytopenia. In a high-technology era, it is rewarding to see the value of a low-technology procedure. Although the authors asserted that coexistence of the two disorders had not been documented, we previously reported a series of three patients with TTP who developed immune thrombocytopenia while their TTP was in remission [2]. Patient 1 in our series initially presented with postpartum TTP ...References1. Olenich M, Schattner E. Postpartum thrombotic thrombocytopenic purpura (TTP) complicating pregnancy-associated immune thrombocytopenic purpura (ITP). Ann Intern Med. 1994; 120:845-7. Google Scholar2. Stein RS, Flexner JM. Idiopathic thrombocytopenic purpura during remission of thrombotic thrombocytopenic purpura. South Med J. 1984; 77:1599-601. Google Scholar Author, Article, and Disclosure InformationAuthors: Richard S. Stein, MD; John M. Flexner, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1994Volume 121, Issue 9 Page: 720-721 Keywords Idiopathic thrombocytopenic purpura Pregnancy Splenectomy Thrombotic thrombocytopenic purpura ePublished: 15 August 2000 Issue Published: 1 November 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
820 HCV GENOTYPE 4 IN SUBJECTS UNDERGOING ANTIVIRAL TREATMENT IN ITALY
Authors: G. Pinzello, T. Stroffolini, M. Vinci, C. Prisco, F. Bandiera, M. Memoli, D. Bacca, L. Nosotti, M. Stanzione, A. Camera, G. Brancaccio, M. Rizzetto
Journal: Journal of Hepatology (2008)
Impact of electrical cardioversion for atrial fibrillation on left atrial appendage function and spontaneous echo contrast: Characterization by simultaneous transesophageal echocardiography
Authors: Richard A. Grimm, William J. Stewart, James D. Maloney, Gerald I. Cohen, Gregory L. Pearce, Eranesto E. Salcedo, Allan L. Klein
Journal: Journal of the American College of Cardiology (1993)
WSX-1 Is Required for Resistance to Trypanosoma cruzi Infection by Regulation of Proinflammatory Cytokine Production
Authors: Shinjiro Hamano, Kunisuke Himeno, Yoshiyuki Miyazaki, Kazunari Ishii, Atsushi Yamanaka, Atsunobu Takeda, Manxin Zhang, Hajime Hisaeda, Tak W. Mak, Akihiko Yoshimura, Hiroki Yoshida
Journal: Immunity (2003)
Decreased Spleen Size and Increased Neutrophils in Patients With Felty Syndrome
Authors: Eric R. Hurd
Journal: JAMA (1976)

Three patients with Felty syndrome were treated with gold sodium thiomalate. In all three, there was an increase in total numbers of peripheral blood neutrophils and total white blood cells, as well as marked clinical improvement of the arthritic complaints. In two patients there was a marked decrease in spleen size. (<i>JAMA</i>235:2215-2217, 1976)
711-1 Angiopeptin Significantly Improves Twelve Months Event Free Survival Following PTCA in a Randomized Double Blind Study
Authors: Håkan Emanuelsson, Kevin J. Beatt, Jens-Peder Bagger, Raphael Balcon, Juhani Heikkila, Jan Piessens, Marc Schaeffer, Harry Suryapranata, Marie L. Foegh
Journal: Journal of the American College of Cardiology (1995)
NMR Studies of Crab and Plaice Metallothioneins
Authors: Denise P. Higham, Jeremy K. Nicholson, Julian Overnell, Peter J. Sadler
Journal: Environmental Health Perspectives (1986)

Metallothioneins isolated from the hepatopancreas of the edible crab (Cancer paqurus) and the plaice (Pleuronectes platessa) after cadmium injection are predominantly cadmium proteins containing only small amounts of zinc and traces of copper. The removal of metal ions from the two metallothioneins by EDTA was studied using proton NMR spectroscopy. The rates of removal of cadmium and zinc were monitored directly from the intensity of the resonances due to the cadmium and zinc-EDTA complexes. Nearly all the zinc present in the protein was extracted by EDTA relatively rapidly, whereas only 10 to 20% of the total cadmium was removed in at least three steps. The total (Cd + Zn) metal removed at equilibrium was 1.2 to 1.8 g-ions/mole protein. Information on conformational changes in the protein were also obtained from studying alterations in the proton resonances of the protein. This was directly correlated with removal of metal from the protein. The coordination environments of the cadmium ions in crab metallothionein were investigated by using 113Cd-NMR, and compared with 113Cd-NMR spectra of rabbit liver MT-II and Scylla serrata MT-I.
P3-07-42: Lymphovascular Invasion Best Correlates with Presence of Nodal Metastasis in Sentinel Lymph Node Biopsy.
Authors: MS Absar, MO Adelekan, E Patel, S Cotterill
Journal: Cancer Research (2011)

Abstract Background. Sentinel lymph node biopsy (SLNB) biopsy is routinely practised for axillary staging with 25–30% having positive SLN. Tumour size is the most important parameter taken into consideration in decision making in node negative patients with a size cut off for 4–5cm dependant on different units. Lymphovascular invasion (LVI) and Ki-67 a cell-cycle antigen are known important prognostic markers along with the tumour grade, oestrogen receptor and herceptin receptor status. Aim. To examine whether lymphovascular invasion, Ki-67 or any other factors can be used as a predictor for axillary lymph node involvement and hence prognosis. METHODS. A prospective study of 264 patients with invasive breast cancer undergoing SLN biopsy between January 2009 and December 2010. Histopathology reports were reviewed regarding LVI, Ki-67, grade, oestrogen, Progesterone and Herceptin receptor and SLN status. Stats direct was used to analyse data. Logistic regression was used and p-value calculated. RESULTS. LVI (p value=0.0001) and size(p value=0.0273) were the two most significant factors associated with node positivity. Grade of tumour had a p-value of 0.0825 and Ki67 had a p-value of 0.5217 which were not significant. DISCUSSION. LVI is the factor which best corelates with presence of metastasis in sentinel lymph node. If this information is available at the time of decision making, it should be strongly considered and pathologists should be encouraged to provide the information. In the absence of LVI, size still remains the best predictor of sentinel lymph node metastasis pre-operatively although consideration of other factors, such as the grade is definitely relevant. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P3-07-42.
Comparison of hepatitis C virus treatment between incarcerated and community patients
Authors: John P. Rice, David Burnett, Helena Tsotsis, Mary J. Lindstrom, Daniel D. Cornett, Patricia Voermans, Jill Sawyer, Rob Striker, Michael R. Lucey
Journal: Hepatology (2012)

The prevalence of chronic hepatitis C virus (HCV) infection among incarcerated individuals in the United States is estimated to be between 12% and 31%. HCV treatment during incarceration is an attractive option because of improved access to health care and directly observed therapy. We compared incarcerated and nonincarcerated HCV-infected patients evaluated for treatment at a single academic center between January 1, 2002 and December 31, 2007. During this period, 521 nonincarcerated and 388 incarcerated patients were evaluated for HCV treatment. Three hundred and nineteen (61.2%) nonincarcerated patients and 234 (60.3%) incarcerated patients underwent treatment with pegylated interferon and ribavirin. Incarcerated patients were more likely to be male, African-American race, and have a history of alcohol or intravenous drug use. Treated incarcerated patients were less likely to have genotype 1 virus and were less likely to have undergone previous treatment. There was a similar prevalence of coinfection with human immunodeficiency virus (HIV) in both groups. A sustained viral response (SVR) was achieved in 97 (42.9%) incarcerated patients, compared to 115 (38.0%) nonincarcerated patients ( P = 0.304). Both groups had a similar proportion of patients that completed a full treatment course. Stepwise logistic regression was conducted, and the final model included full treatment course, non-genotype 1 virus, younger age at treatment start, and negative HIV status. Incarceration status was not a significant predictor when added to this model ( P = 0.075). Conclusion : In a cohort of HCV-infected patients managed in an academic medical center ambulatory clinic, incarcerated patients were as likely to be treated for HCV and as likely to achieve an SVR as nonincarcerated patients. (Hepatology 2012)
ARSENOTHERAPY IN THE TREATMENT OF EOSINOPHILIC PNEUMONOPATHY
Authors: William G. Ensign
Journal: JAMA (1952)

The term "eosinophilic pneumonopathy syndrome" was introduced by Apley and Grant<sup>1</sup>in 1944 to describe the various conditions that present the combination of eosinophilia and pulmonary lesions. Under this term was included Loeffler's syndrome, tropical eosinophilia, bronchial asthma, periarteritis nodosa, and some intestinal infestations. Their contention was that the differentiation between Loeffler's syndrome and tropical eosinophilia was more apparent than real and that they should be considered as the manifestation of one type of disease process. Recently when Vines and Clarke<sup>2</sup>reported a case with eosinophilia and pulmonary infiltrations they employed this term because the disease could not be properly placed in any specific category. Greig<sup>3</sup>also regarded Loeffler's syndrome and tropical eosinophilia as identical diseases. The picture is further confused by the use of other terms to describe this combination. Reiman<sup>4</sup>described it as allergic pneumonia. Others have used pseudotuberculosis associated with eosinophilia,<sup>5</sup>Loeffler's
What If Physicians Actually Had to Control Medical Costs?
Authors: Robert H. Brook
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Response to Open Peer Commentaries on “Accidental Communities: Race, Emergency Medicine, and the Problem of PolyHeme”: The “R” Word: Bioethics and a (Dis)Regard of Race
Authors: Karla F. C. Holloway
Journal: The American Journal of Bioethics (2006)

I have read with appreciation and some curiosity the responses to my essay “Accidental Communities: Race, Emergency Medicine, and the Problem of PolyHeme®.” My appreciation extends from the thought...
Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked celery in patients with celery allergy
Authors: B. K. Ballmer‐Weber, A. Hoffmann, B. Wüthrich, D. Lüttkopf, C. Pompei, A. Wangorsch, M. Kästner, S. Vieths
Journal: Allergy (2002)

Background: Celery root is often consumed in a processed form as a cooked vegetable or as a spice. So far, however, there has been no information about the allergenicity of processed celery in celery‐allergic patients. Methods: In 12 patients with a history of allergic reactions to raw or raw and cooked celery, double‐blind placebo‐controlled food challenges (DBPCFCs) with raw celery ( n = 10), cooked celery (110°C/15 min; n = 11), and celery spice ( n = 5) were performed. Nine patients underwent an open mucosal challenge with four samples of canned celery retorted at Co‐values (cooking effect) of 7.45–76.07 (corresponding to the time periods in minutes at a thermal influence of 100°C). IgE immunoblot analysis of celery extract was performed with sera of all challenged patients. The thermal stability of celery allergen was investigated by enzyme allergosorbent test (EAST) inhibition. Furthermore, intraperitoneal immunization of mice followed by a rat basophil leukemia (RBL) cell mediator release assay was used as a biological in vitro model to assess the allergenicity of processed celery. Results: Six out of 11 patients showed a positive DBPCFC to cooked celery and five out of five patients to celery spice. Allergenicity of celery was preserved in four patients with a positive DBPCFC to cooked celery even if celery was treated at a Co‐value of 76.07. Patients with positive DBPCFC to cooked celery reacted to known celery allergens (Api g 1, Api g 4, cross‐reactive carbohydrate determinants CCD). EAST inhibition showed that heat resistance of celery allergens decreases in the following order: CCD &gt; Api g 4 &gt; Api g 1. Accordingly, five of six patients with a positive DBPCFC to cooked celery were sensitized to profilin and/or CCD. The murine model reflected the reactivity of patients sensitized to the major allergen Api g 1. Conclusions: 1) In a subset of patients with a positive DBPCFC to cooked celery, celery remains allergenic even after extended thermal treatment (76.07 min/100°C). 2) Celery spice is allergenic for patients with an allergy to raw celery. 3) RBL cells sensitized with mouse IgE to raw celery may serve as a useful tool for screening the potential allergenicity of heat‐processed products containing celery.
Sensation seeking: A comparative approach to a human trait
Authors: Marvin Zuckerman
Journal: Behavioral and Brain Sciences (1984)

Abstract A comparative method of studying the biological bases of personality compares human trait dimensions with likely animal models in terms of genetic determination and common biological correlates. The approach is applied to the trait of sensation seeking, which is defined on the human level by a questionnaire, reports of experience, and observations of behavior, and on the animal level by general activity, behavior in novel situations, and certain types of naturalistic behavior in animal colonies. Moderately high genetic determination has been found for human sensation seeking, and marked strain differences in rodents have been found in open-field behavior that may be related to basic differences in brain neurochemistry. Agonistic and sociable behaviors in both animals and humans and the trait measure of sensation seeking in humans have been related to certain common biological correlates such as gonadal hormones, monoamine oxidase (MAO), and augmenting of the cortical evoked potential. The monoamine systems in the rodent brain are involved in general activity, exploratory behavior, emotionality, socialization, dominance, sexual and consummately behaviors, and intracranial self-stimulation. Preliminary studies have related norepinephrine and enzymes involved in its production and degradation to human sensation seeking. A model is suggested that relates mood, behavioral activity, sociability, and clinical states to activity of the central catecholamine neurotransmitters and to neuroregulators and other transmitters that act in opposite ways on behavior or stabilize activity in the arousal systems. Stimulation and behavioral activity act on the catecholamine systems in a brain–behavior feedback loop. At optimal levels of catecholamine systems activity (CSA) mood is positive and activity and sociability are adaptive. At very low or very high levels of CSA mood is dysphoric, activity is restricted or stereotyped, and the organism is unsocial or aggressively antisocial. Novelty, in the absence of threat, may be rewarding through activation of noradrenergic neurons.
Absent Vas Deferens Associated With Renal Agenesis
Authors: Mims Gage Ochsner
Journal: JAMA (1972)

Inability to palpate the vas deferens in routine examination should alert the physician to explore the possibility of associated renal anomalies. We encountered four clinical cases of congenital unilateral renal agenesis associated with ipsilateral agenesis of the vas deferens.
Continuous versus inpatient prophylaxis of the first episode of spontaneous bacterial peritonitis with norfloxacin
Authors: M Novella, R Sola, G Soriano, M Andreu, J Gana, J Ortiz, S Coll, M Sabat, M C Vila, C Guarner, F Vilardell
Journal: Hepatology (1997)

Cirrhotic patients with ascites and low ascitic fluid total protein and/or high serum bilirubin levels are at high risk to develop the first episode of spontaneous bacterial peritonitis during long–term follow–up. The aim of the present study was to determine the efficacy of continuous long–term selective intestinal decontamination with norfloxacin in the prevention of this complication. One hundred nine cirrhotic patients with ascites and ascitic fluid total protein levels of ≤ 1 g/dL or serum bilirubin levels of &gt; 2.5 mg/dL without previous spontaneous bacterial peritonitis were prospectively randomized into two groups: group 1 (n = 56) received norfloxacin, 400 mg daily administered orally, and group 2 (n = 53) was the long–term control group, receiving norfloxacin only during hospitalization. During a mean follow–up of 43 +/– 3 weeks, there was one spontaneous bacterial peritonitis (1.8%) in group 1 and 9 (16.9%) in group 2 (P &lt; .01). The incidence of community–acquired spontaneous bacterial peritonitis was lower in group 1 (1.8% vs. 13.2%, P &lt; .05), whereas the incidence of nosocomial spontaneous bacterial peritonitis (0% vs. 3.7%) and the incidence of extraperitoneal infections (25% vs. 24.5%) were similar in both groups (P = NS). The actuarial probability of survival at 18 months was 75% in group 1 and 62% in group 2 (P = NS). Resistance to norfloxacin was observed in 9 of 10 (90%) Escherichia coli isolated in infections from group 1 and in 4 of 11 (36.3%) from group 2 (P &lt; .05). The overall incidence of infections caused by norfloxacin–resistant bacteria was higher in group 1 (19.6% vs. 15%), but it did not reach statistical significance. Continuous long–term selective intestinal decontamination with norfloxacin is effective in preventing the first spontaneous bacterial peritonitis in cirrhotic patients at high risk. However, the emergence of infections caused by norfloxacin–resistant bacteria must be weighed carefully against the benefits of continuous long–term prophylaxis.