Losartan-Induced Acute Pancreatitis
Authors: Xavier Bosch
Journal: Annals of Internal Medicine (1997)

Letters1 December 1997Losartan-Induced Acute PancreatitisXavier Bosch, MD, PhDXavier Bosch, MD, PhDHospital Casa Maternitat; 08028-Barcelona, SpainAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-11-199712010-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Losartan is a nonpeptide angiotensin II type 1 receptor antagonist that has recently been licensed for the treatment of hypertension in many countries [1]. Its side effects include hypotension, renal dysfunction, and hyperkalemia. Uncommon serious adverse events include worsening heart failure, unstable angina, and myocardial infarction [1-3].I describe a 39-year-old man who developed acute pancreatitis while receiving losartan. In July 1996, he presented with a 3-day history of nausea, vomiting, and constant pain in the epigastrium that radiated to the flanks. He had been well until 5 months previously, when enalapril, 10 mg once daily, was ...References1. Pitt B, Segal R, Martinez FA, Meuers G, Cowley AJ, Thomas I, et al. Randomised trial of losartan versus captopril in patients over 65 with heart failure (Evaluation of Losartan in the Elderly Study, ELITE). Lancet. 1997; 349:747-52. Google Scholar2. Crozier I, Ikram H, Awan N, Cleland J, Stephen N, Dickstein K, et al. Losartan in heart failure: hemodynamic effects and tolerability. Circulation. 1995; 91:691-7. Google Scholar3. Gottlieb SS, Dickstein K, Fleck E, Kostis J, Levine TB, LeJemtel T, et al. Hemodynamic and neurohormonal effects of the angiotensin II antagonist losartan in patients with congestive heart failure. Circulation. 1993; 88:1602-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: Hospital Casa Maternitat; 08028-Barcelona, Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEver-increasing diversity of drug-induced pancreatitisDrug induced pancreatitis: A systematic review of case reports to determine potential drug associationsDrug-Induced Acute Pancreatitis in AdultsNo association between losartan use and acute pancreatitis in hypertensive patientsAngiotensin II receptor antagonistsPancreatitis aguda en un paciente tratado con losartánValsartan-induced Acute PancreatitisCardiovascular Disease and Risk of Acute Pancreatitis in a Population-Based StudyAntacid-Induced Acute PancreatitisValsartan, a specific angiotensin II receptor blocker, inhibits pancreatic fluid secretion via vagal afferent pathway in conscious ratsThe Renin–Angiotensin System and Reactive Oxygen Species: Implications in PancreatitisDrugs Used to Treat Hypertension, Heart Failure, and Angina PectorisUse of Angiotensin II Receptor Blockers and the Risk of Acute Pancreatitis: A Nested Case-Control StudyAngiotensin II Receptor Blockade Administered after Injury Improves Muscle Regeneration and Decreases Fibrosis in Normal Skeletal MuscleDrug-Induced PancreatitisDrug-Induced Acute Pancreatitis: An Evidence-Based ReviewNitroprusside, ACE Inhibitors, and Other Cardiovascular AgentsAngiotensin II receptor antagonistsAcute Pancreatitis Associated With Irbesartan TherapyFatal Acute Pancreatitis in a Patient Chronically Treated with CandesartanCandesartan Cilexetil-Induced Severe HepatotoxicityAcute Pancreatitis Associated with Angiotensin II Receptor AntagonistsAntihypertensive drugsPancreatitis after losartanLosartan potassium 1 December 1997Volume 127, Issue 11Page: 1043-1044KeywordsAcute pancreatitisHypertensionLipasesNauseaPancreasResearch laboratoriesSerious adverse eventsUltrasound imagingUnstable anginaVomiting ePublished: 15 August 2000 Issue Published: 1 December 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...