tbuckley/cabot-search huggingface dataset:
Atrial Fibrillation After Radiofrequency Ablation of Type I Atrial Flutter
Authors: Hakan Paydak, John G. Kall, Martin C. Burke, Donald Rubenstein, Douglas E. Kopp, Ralph J. Verdino, David J. Wilber
Journal: Circulation (1998)

The occurrence of atrial fibrillation after ablation of type I atrial flutter remains an important clinical problem. To gain further insight into the pathogenesis and significance of postablation atrial fibrillation, we examined the time to onset, determinants, and clinical course of atrial fibrillation after ablation of type I flutter in a large patient cohort.Of 110 consecutive patients with ablation of type I atrial flutter, atrial fibrillation was documented in 28 (25%) during a mean follow-up of 20.1+/-9.2 months (cumulative probability of 12% at 1 month, 23% at 1 year, and 30% at 2 years). Among 17 clinical and procedural variables, only a history of spontaneous atrial fibrillation (relative risk 3.9, 95% confidence intervals 1.8 to 8.8, P=0.001) and left ventricular ejection fraction <50% (relative risk 3.8, 95% confidence intervals 1.7 to 8.5, P=0.001) were significant and independent predictors of subsequent atrial fibrillation. The presence of both these characteristics identified a high-risk group with a 74% occurrence of atrial fibrillation. Patients with only 1 of these characteristics were at intermediate risk (20%), and those with neither characteristic were at lowest risk (10%). The determinants and clinical course of atrial fibrillation did not differ between an early (< or = 1 month) compared with a later onset. Atrial fibrillation was persistent and recurrent, requiring long-term therapy in 18 patients, including 12 of 19 (63%) with prior atrial fibrillation and left ventricular dysfunction.Atrial fibrillation after type I flutter ablation is primarily determined by the presence of a preexisting structural and electrophysiological substrate. These data should be considered in planning postablation management. The persistent risk of atrial fibrillation in this population also suggests a potentially important role for atrial fibrillation as a trigger rather than a consequence of type I atrial flutter.
Crohn's disease and ulcerative colitis in the same patient.
Authors: C L White, S R Hamilton, M P Diamond, J L Cameron
Journal: Gut (1983)

A well documented case of a patient with both Crohn9s disease and ulcerative colitis is presented. A 29 year old woman underwent resection of her terminal ileum and ascending colon for typical Crohn9s disease with ileocolitis. Eleven years later, an ileoproctocolectomy was performed for typical ulcerative colitis involving the left colon. The resection specimen also showed evidence of colonic Crohn9s disease near the anastomotic site. This unusual case shows that Crohn9s disease and ulcerative colitis can occur in the same patient. The rarity of such cases supports the concept that Crohn9s disease and ulcerative colitis are separate entities, rather than different manifestations of the same disease process.
Prediction of risk of liver disease by alcohol intake, sex, and age: A prospective population study
Authors: U Becker, A Deis, T I Sorensen, M Gronbaek, K Borch-Johnsen, C F Muller, P Schnohr, G Jensen
Journal: Hepatology (1996)

The association between self-reported alcohol intake and the risk of future liver disease was studied in a large population-based prospective cohort with 12-year follow-up. Alcohol intake was assessed in 13,285 men and women aged 30 to 79 years by a self-administered questionnaire. Diagnoses indicating alcohol-induced liver disease (n − 261) or alcohol-induced cirrhosis (n − 124) were obtained from death certificates and the hospital discharge register, and data were analyzed by multiplicative Poisson regression models. The total cumulated observation time was 130,558 person-years. The overall incidence rates of alcohol-induced cirrhosis were 0.2% per year in men and 0.03% per year in women. The nadir of the estimated relative risk of developing liver disease was observed at an alcohol intake of 1 to 6 beverages per week, and above this level a steep increase in relative risk was observed. The risk function was independent of age and stable over time. The level of alcohol intake above which the relative risk was significantly greater than 1 was observed at 7 to 13 beverages per week for women and 14 to 27 beverages per week for men. Women had a significantly higher relative risk of developing alcohol-related liver disease than men for any given level of alcohol intake. We observed a dose-dependent increase in relative risk of developing alcohol-induced liver disease for both men and women, with the steepest increase among women. In the general population, self-reported current alcohol intake is a good predictor of the future risk of alcohol-induced liver disease.
Hepatitis E Virus Infection as a Possible Cause of Acute Liver Failure in Europe
Authors: Paul Manka, Lars P. Bechmann, Jason D. Coombes, Viktoria Thodou, Martin Schlattjan, Alisan Kahraman, Wing-Kin Syn, Fuat Saner, Guido Gerken, Hideo Baba, Jens Verheyen, Jörg Timm, Ali Canbay
Journal: Clinical Gastroenterology and Hepatology (2015)
Abstract 444: Subpopulations of circulating microvesicles have different microRNA profiles
Authors: Ta Deng, David B. Spetzler, Daniel Holterman, Traci Pawlowski, Janet E. Duncan, Shannon E. Smith, Katrina Radebach, Tanya LIttle, Christine D. Kuslich
Journal: Cancer Research (2011)

Abstract The purpose of this study was to determine if circulating microvesicle (cMV) subpopulations as defined by surface protein composition also exhibit distinct microRNA (miR) expression patterns. Circulating microvesicles isolated from a prostate cancer cell line (VCaP) were sorted based on their surface protein composition and were evaluated for differential expression of miRs. Phycoerythrin-labeled antibodies targeting EpCam, CD63, or B7-H3 were used to sort the subpopulations of cMVs by fluorescence-activated cell sorting. The sorted subpopulations of cMVs were subsequently profiled by miR expression. The miR profiles for the EpCam-, CD63-, and B7-H3-positive subpopulations were compared with the profile of the total VCaP cMV population. Differential miR expression patterns were observed across the subpopulations, and all expression patterns were distinct from that observed in the total population. Patterns of both over- and under-expression were seen. Not only can subpopulations of cMVs be distinguished and separated based on surface protein markers, but they can also be differentiated based on their RNA content, in this case miRs. The ability to isolate tissue-specific cMV populations from patient plasma based on surface protein composition and then analyze them based on both surface protein composition and genetic content has considerable diagnostic, prognostic, and theranostic implications. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 444. doi:10.1158/1538-7445.AM2011-444
On Tapping the Pericardial Sac
Authors: G. Sharp
Journal: BMJ (1895)

ZIA J stage," and urges that "this alternation of symptoms from one eye to the other is a diagnostic distinction between inflammations confined to the orbital cavity and cavernous sinus thrombosis."In this case, as in those published by Dr. Sidney Phillips, the eye symptoms remained unilateral, an.d what is more, all the cases recovered, whilst Dr. Macewen states that " absolutely all those cases due to infective thrombosis (of cavernous sinus) end fatally."
Carbon monoxide yields of cigarettes and their relation to nicotine yield and type of filter.
Authors: M A Russell, P V Cole, M S Idle, L Adams
Journal: BMJ (1975)

Carbon monoxide (CO) yields of 11 popular brands of British cigarette, two types of cigarette containing tobacco-substitute, and one brand of cigar were measured under standardized conditions. Yields of the conventional cigarettes ranged from 5.0 to 20.2 mg per cigarette (1.3 to 4.7% by volume). The cigar yielded 81.7 mg (10.0%) CO and the two semi-synthetic cigarettes 17.2 (4.2%) and 28.2 mg (6.2%) CO. Puff-by-puff analysis showed an increase in CO concentration as a cigarette is smoked. In brands with nicotine yields over 1.0 mg no relationship was apparent between nicotine yield and CO yield, and the filters of cigarettes in this category did not appear to reduce the CO yield. In the low nicotine cigarettes with ventilated filters there appeared to be some correlation between nicotine yield and CO yield, and these filters were highly effective in reducing CO yield, owing mainly to the ventilation. We suggest that official publication of CO yields might motivate manufacturers to produce cigarettes with lower yields.
Commentary: Controversies in NICE guidance on surgical site infection
Authors: Z. H Krukowski, J. Bruce
Journal: BMJ (2008)

Major innovations and improvements have taken place over the past 20 years in the management of infected surgical sites, including the development of sophisticated wound dressings and specialist tissue viability nurses. However, we should not be complacent about surgical site infection as recent surveillance data for England show the rate to be as high as 10.5% after small bowel surgery,1 and a Scottish study found a rate of 5.3% for clean abdominal (hernia) surgery.2 As acknowledged in the latest guidance from the National Institute for Clinical Excellence (NICE),3 many confounding factors affect the identification of surgical site infection, not least 41 definitions and a variation in surveillance methods. However, it has been clear for almost three decades that the routine collection and dissemination of rates of surgical site infection results indirectly in a worthwhile reduction.4 The Scottish Surveillance of Healthcare Associated Infection Programme reported significant reductions in the rate surgical site …
NEUTRALIZATION OF INFLUENZA A VIRUS BY HUMAN SERUM
Authors: Frank L. Horsfall, Edwin H. Lennette
Journal: The Journal of Experimental Medicine (1941)

A linear relationship exists between the quantity of human serum used and the quantity of influenza A virus neutralized. By means of this relationship it is possible to determine the maximum quantity of virus which a given human serum can neutralize. This quantity, the neutralizing capacity, is a fixed value and, unlike the serum dilution end point, is independent of the amount of virus used in the neutralization test.
Effective Destruction of Fas-deficient Insulin-producing β Cells in Type 1 Diabetes
Authors: Irina Apostolou, Zhenyue Hao, Klaus Rajewsky, Harald von Boehmer
Journal: The Journal of Experimental Medicine (2003)

In type 1 diabetes, autoimmune T cells cause destruction of pancreatic β cells by largely unknown mechanism. Previous analyses have shown that β cell destruction is delayed but can occur in perforin-deficient nonobese diabetic (NOD) mice and that Fas-deficient NOD mice do not develop diabetes. However, because of possible pleiotropic functions of Fas, it was not clear whether the Fas receptor was an essential mediator of β cell death in type 1 diabetes. To directly test this hypothesis, we have generated a β cell–specific knockout of the Fas gene in a transgenic model of type 1 autoimmune diabetes in which CD4+ T cells with a transgenic TCR specific for influenza hemagglutinin (HA) are causing diabetes in mice that express HA under control of the rat insulin promoter. Here we show that the Fas-deficient mice develop autoimmune diabetes with slightly accelerated kinetics indicating that Fas-dependent apoptosis of β cells is a dispensable mode of cell death in this disease.
Assessing the Risk of Ovarian Hyperstimulation Syndrome in Egg Donation: Implications for Human Embryonic Stem Cell Research
Authors: Brooke Ellison, Jaymie Meliker
Journal: The American Journal of Bioethics (2011)

Stem cell research has important implications for medicine. The source of stem cells influences their therapeutic potential, with stem cells derived from early-stage embryos remaining the most versatile. Somatic cell nuclear transfer (SCNT), a source of embryonic stem cells, allows for understandings about disease development and, more importantly, the ability to yield embryonic stem cell lines that are genetically matched to the somatic cell donor. However, SCNT requires women to donate eggs, which involves injection of ovulation-inducing hormones and egg retrieval through laparoscopy or transvaginal needle aspiration. Risks from this procedure are fiercely debated, most notably risk of ovarian hyperstimulation syndrome (OHSS). This review examines risk of OHSS resulting from oocyte donation. We conclude that risk posed by OHSS in egg donation is not significant enough to warrant undue concern, and much of this can be eliminated when proper precautions are taken. This bears relevance to the future of stem cell research policymaking.
USE OF CLOVER'S INHALER IN TONSILLECTOMY AND REMOVAL OF ADENOIDS
Authors: C. J. Symonds
Journal: BMJ (1928)

CLOVER'S INHAtER IN TONSILLPCTOMY.581service would be adopted.He did not suggest that nio developiment of these clinics should take place apart fiom the local educatiolnal authority, but rather that there should be a close co-operation.Thus the active interest of the local authority should be won for a clillic, evell tlhoughi not directly initiated, financed, or controlled by it.Dr. Crowley paid high tribute to the child guidance work already existing in Great Biritaini, mentioniing clinics at various hospitals and institutions, both me-dical and educa- tional.He referred particularly to the outstandinig work of Pr ofessor Cyril Burt as psychologist to the Lonidon 'County Counicil, and to that of Dr.
IMMUNOPATHOLOGICAL INVESTIGATIONS IN THE SENEARUSHER SYNDROME (COEXISTENCE OF PEMPHIGUS AND LUPUS ERYTHEMATOSUS)
Authors: T. CHORZELSKI, S. JABLOŃSKA, M. BLASZCZYK
Journal: British Journal of Dermatology (1968)

SUMMARY.— In 5 of 6 cases of the Senear-Usher syndrome, in skin specimens from erythematous facial lesions, the immunofluorescence method demonstrated immunoglobulins and in vivo-fixed complement in the dermoepidermal junction, which is a finding characteristic of lupus erythematosus. Antibodies against nuclei were also present in all but one case, and in one there was coexistent systemic lupus erythematosus with positive LE phenomenon. In all 6 cases of the SU syndrome the presence of IgG as well as C′3a, C′4 was demonstrated in the intercellular spaces of the epidermis; this is a finding characteristic of pemphigus. In 6 cases of pemphigus vulgaris, which served as controls, neither immuno-globulins nor in vivo-fixed complement could be demonstrated in the dermoepidermal junction. These investigations suggest that the SU syndrome could, at least in the vast majority of cases, result from the coexistence of pemphigus and lupus erythematosus.
Inverse Association Between Fish Intake and Risk of Glucose Intolerance in Normoglycemic Elderly Men and Women
Authors: Edith JM Feskens, Carel H Bowles, Daan Kromhout
Journal: Diabetes Care (1991)

Objective To examine the association of fish intake with the subsequent risk of impaired glucose tolerance and diabetes mellitus (glucose intolerance). Research Design and Methods In 1971, information about food intake was obtained by the cross-check dietary history method on 175 men and women aged 64-87 yr who were normoglycemic and free of clinical diabetes. During the follow-up period from 1972 to 1975, an oral glucose tolerance test was performed annually, and in 59 of 175 elderly people a diagnosis of glucose intolerance was made at least once. Results In 1971, ~ 60% of the subjects usually ate fish, with a mean daily intake of 24.2 g. In fish eaters, the incidence of glucose intolerance was significantly lower compared with nonfish eaters (odds ratio [OR] 0.40, 95% confidence interval [CI] 0.21-0.77). With logistic regression analysis, this inverse association could not be explained by taking into account age and sex or possible confounding baseline characteristics, such as the prevalence of myocardial infarction, body mass index, energy intake per kilogram body weight, or intake of carbohydrates (OR 0.47, 95% CI 0.23-0.93). Baseline characteristics of the oral glucose tolerance test and serum triglyceride levels could also not account for this result. Conclusions These results suggest that, in an elderly population, the habitual consumption of a small amount of fish may protect against the development of impaired glucose tolerance and diabetes mellitus.
Effect of combined treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and phototherapy on bilirubin metabolism in the jaundiced gunn rat
Authors: Arnold N. Cohen, Jaime Kapitulnik, Donald J. Ostrow, Cecile C. Webster
Journal: Hepatology (1986)

2,3,7,8-Tetrachlorodibenzo-p-dioxin, a potent inducer of microsomal cytochrome P448-dependent monoxygenases, and phototherapy both accelerate bilirubin metabolism and decrease jaundice in Gunn rats. The effects of combined treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and light were studied in these rats by applying phototherapy for 65 hr, beginning 5 days after induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin. 2,3,7,8-Tetrachlorodibenzo-p-dioxin pretreatment caused a 75% decline in plasma bilirubin in 5 days, with no change thereafter, whether or not the rats were exposed subsequently to phototherapy. In the uninduced rats, plasma bilirubin levels declined by 55% after 40 hr of phototherapy. As determined by [14C]bilirubin kinetics, both 2,3,7,8-tetrachlorodibenzo-p-dioxin and phototherapy increased fractional bilirubin turnover and decreased the total bilirubin pool. In the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced rats, the contracted bilirubin pool shifted from skin to liver, but these tissue pools did not change further during phototherapy. By contrast, in uninduced rats, phototherapy decreased the cutaneous bilirubin pool, which is the main target of phototherapy. 2,3,7,8-Tetrachlorodibenzo-p-dioxin was more effective than phototherapy in diminishing plasma bilirubin levels and the total bilirubin pool, but the combined treatment (2,3,7,8-tetrachlorodibenzo-p-dioxin followed by phototherapy) was no more effective than 2,3,7,8-tetrachlorodibenzo-p-dioxin alone.
Tuberculous peritonitis and laparotomy.
Authors: M F Dixon, J A Davies
Journal: BMJ (1973)

Tuberculous Peritonitis and Laparotomy M. F. Dixon, M.B., and J. A. Davies, M.R.C.P. 674 Hospital Advisory Service G. W. Taylor, M.R.C.G.P   674 Rh Immunization in Ruptured Tubal Pregnancy R. D. Barr, M.R.C.P   674 Thiocyanate Metabolism in Human Vitamin Bi Deficiency A. G. Freeman, F.R.C.P   675 Children of Anaesthetists R. Wyatt, M.B., D.A. and A. M. Wilson, F.F.A. R.C.S.   675 Contact Sensitivity to Toothpaste L. G. Millard, M.R.C.P   676 Constraints on Consultants R. D. Scott, M.R.C.P   676 Tumoral Calcinosis in Britian K. S. Vasudev, M.B., and others 676 Drop Attacks in Women -N. Capener, F.R.C.S.; T. E. Lear, M.R.C.PSYCH. 676 Cell-mediated Immunity in Thyroid Disease N. R. Farid and others   677 Teachers and Patients H. H. 0. Wolff, F.R.C.P   677 Serum Alkaline Phosphatase and Rickets in Urban Schoolchildren A. S. Truswell, M.D   677 Lignocaine in Donor Blood J. A. G. da Costa, M.R.C.P., and others ...... 677 Congenital Hemihypertrophy A. W. Johnston, M.D   678 Day Hospitals and Day Centres J. R. Wilkie, M.B   678 Diseases of Western Civilization Surgeon Captain T. L. Cleave, M.R.C.P.; W. M. Castleden, F.R.A.C.S   678 Viral Infection and Renal Transplant Rejection J. R. T. Gabriel, M.R.C.P., and others...... 679 Postherpetic Neuralgia J. M. S. Pearce, M.D   679 Tragic Dilemma J. Lowther, M.B   679 Oil Myelography D. J. Mitchell, F.F.R.R.C.S.I   680 Efficacy of Whooping-cough Vaccines G. W. J. Bousfield, M.D   680 Immunization against Influenza T. C. G. Smith, M.B   680 Short-term Service Abroad P. Rabindran, M.R.C.P   680 Role ofPacing after Myocardial Infarction Helen H. Tucker, M.B., and others ........ 680 Cranial Nerve Palsy in Tetanus R. P. Patel, M.B., and M. Sorokin  681 Mode of Action of Verapamil D. G. McDevitt, M.D., and R. G. Shanks, M.D   681 Gateshead Tuberculin Survey E. L. Feinmann, F.R.C.P., and others ...... 681 Pregnancy after Hysterotomy R. F. Heys, M.R.C.O.G  681 Loin Percussion in Acute Pyelonephritis B. T. B. Manners, M.R.C.P  682 Earnings of General Practitioners J. Winter, M.D.; E. Platts, M.R.C.O.G.......682 Management of the N.H.S. P. N. Dixon, D.P.H  682 London Pride? R. Buchan, F.R.C.S.ED  682
False-Positive Iodine Uptake in Thymic Hyperplasia on Diagnostic I-123 Whole-Body Scan After Total Thyroidectomy
Authors: Seung-Hwan Lee, Hyuk-Sang Kwon, I-Ryung Yoo, Hyun-Jin Park, Kun-Ho Yoon, Bong-Yun Cha, Ho-Young Son
Journal: Clinical Nuclear Medicine (2007)

A 0.8 × 0.8 × 0.6 cm-sized thyroid nodule was found incidentally 9 months ago in a 45-year-old woman who had been diagnosed with papillary thyroid carcinoma. She had undergone total thyroidectomy and postoperative thyroglobulin levels had been maintained below 0.3 ng/mL. Follow-up diagnostic I-123 whole-body scan showed the possibility of recurrence or metastasis and thyroglobulin levels had increased to 5.3 ng/mL with thyroxine withdrawal. Magnetic resonance imaging revealed similar findings of possible recurrence. Considering recurrence or metastastatic carcinoma, surgical excision was performed but the microscopic examination of the mediastinal mass demonstrated a normal lobular architecture of the thymus.
Home solarium treatment of psoriasis
Authors: O. LARKO, G. SWANBECK
Journal: British Journal of Dermatology (1979)

Journal Article Home solarium treatment of psoriasis Get access O. LARKÖ, O. LARKÖ Department of Dermatology, University of Gothenburg, Sahlgren's Hospital, Gothenburg, Sweden Search for other works by this author on: Oxford Academic Google Scholar G. SWANBECK G. SWANBECK Department of Dermatology, University of Gothenburg, Sahlgren's Hospital, Gothenburg, Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 101, Issue 1, 1 July 1979, Pages 13–16, https://doi.org/10.1111/j.1365-2133.1979.tb15286.x Published: 01 July 1979
Oxidant-mediated epithelial cell injury in idiopathic pulmonary fibrosis.
Authors: A M Cantin, S L North, G A Fells, R C Hubbard, R G Crystal
Journal: Journal of Clinical Investigation (1987)

Lung inflammatory cells of patients with idiopathic pulmonary fibrosis (IPF) were evaluated for their ability to injure 51Cr-labeled AKD alveolar epithelial cells in the presence and absence of IPF alveolar epithelial lining fluid (ELF). The IPF cells were spontaneously releasing exaggerated amounts of superoxide (O.2) and hydrogen peroxide (H2O2) compared with normal (P less than 0.02). Cytotoxicity of the AKD cells was markedly increased when the IPF inflammatory cells were incubated with autologous ELF (P less than 0.02). The majority of IPF patients had ELF myeloperoxidase levels above normal (P less than 0.002). Incubation of IPF ELF with AKD cells in the presence of H2O2 caused increased cellular injury (P less than 0.01 compared with control), which was suppressed by methionine, a myeloperoxidase system scavenger. IPF patients with high concentrations of ELF myeloperoxidase deteriorated more rapidly than those with low ELF myeloperoxidase (P less than 0.05). Thus, IPF is characterized by an increased spontaneous production of oxidants by lung inflammatory cells, the presence of high concentrations of myeloperoxidase in the ELF of the lower respiratory tract, and a synergistic cytotoxic effect of alveolar inflammatory cells and ELF on lung epithelial cells, suggesting oxidants may play a role in causing the epithelial cell injury of this disorder.