tbuckley/cabot-search huggingface dataset:
Plasminic Activity and Emotional Stress
Authors: Hideki Teshima, Sadahisa Inoue, Yukihiro Ago, Yujiro Ikemi
Journal: Psychotherapy and Psychosomatics (1974)

Hereditary angioneurotic edema (HANE) is clearer in the etiology than the other types of angioneurotic edema. It shows abnormal serum complemental activity and various clinical signs. It has been reported by many clinicians that the onset and the progress of this disease are frequently and deeply concerned with emotional stress. The two cases, showing that the symptoms of HANE occurred repeatedly in stressful situations were presented. To make the relationship between emotions and the symptoms clearer, plasmin which induced the serum complemental activation, was picked up. Plasminic activity was measured during the adrenaline test. The result showed that plasminic activity increased and returned to normal following the bodily response, i.e. the change of pulse rate, blood pressure, pulse wave and urinary catecholamine, to the adrenaline. In the animal experiment, the stimulation of the rats by light, buzzer and electric current, increased the plasma plasminic activity, and results showed a peculiar fluctuation of plasminic activity; in the chronic stress groups, this response being greater than that of the group without the chronic stress. From these findings, the emotional stress is considered to accelerate the plasminic activity through the autonomic nervous system, and to act as the trigger in HANE. The relation between plasminic activity and the hormonal feedback was examined, according to the results that urinary excretion of 17 OHCS reduced when plasma plasminic activity increased, and that the increased plasminic activity interfered with the hormonal feedback. Plasmin which acts on many substances, is activated easily by emotional stress, especially in allergic diseases.
Using Existing Systematic Reviews in Complex Systematic Reviews
Authors: Evelyn P. Whitlock, Jennifer S. Lin, Roger Chou, Paul Shekelle, Karen A. Robinson
Journal: Annals of Internal Medicine (2008)

Systematic reviewers increasingly must decide whether and how to incorporate existing systematic reviews into complex systematic reviews that are commissioned to support clinical guideline development or for other health policy uses. To date, however, this issue has been largely unexamined. Reviewers seeking to incorporate existing reviews into new reviews face a set of important questions: Can this practice adhere to systematic review principles? Will it save time? When should it be avoided? Will it produce valid results and be acceptable to users? Drawing from their collective experience, the authors outline a series of steps that can help reviewers reach reasoned decisions about the incorporation of existing systematic reviews and enumerate potential hazards to consider in doing so. They highlight issues surrounding the main steps reviewers must undertake, including locating existing reviews; assessing their relevance to the new review; assessing the quality of relevant reviews; determining how to incorporate high-quality, relevant existing systematic reviews; and clearly reporting the methods used and the results from this process. Further specification of methods, including the development of reporting standards for this approach, is needed.
Delayed Blanch and Opacity Pulse in Atopic Dermatitis
Authors: A. Macmillan
Journal: British Journal of Dermatology (1969)

Journal Article Delayed Blanch and Opacity Pulse in Atopic Dermatitis Get access A. Macmillan A. Macmillan Department of Dermatology Royal Free Hospital, London W.C.I Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 8, 1 August 1969, Page 631, https://doi.org/10.1111/j.1365-2133.1969.tb16050.x Published: 01 August 1969
Giant Colonic Diverticulum
Authors: P Ueda, D Hall
Journal: New England Journal of Medicine (1995)

Figure 1. A 70-year-old woman had a six-month history suggestive of recurrent, self-limited episodes of acute diverticulitis. A scout film for a barium enema showed a rounded, smooth-walled structure measuring 10 cm in diameter and containing air (Panel A). The barium enema showed entry of contrast medium into the structure (Panel B). Puddling and the even distribution of barium within the structure in all positions suggested that this was most likely a large sigmoid diverticulum. Surgery was scheduled, but before the scheduled date the patient presented with an acute abdomen. A plain film showed that the diverticulum had enlarged to . . .
Continental doctors take up top posts in UK heart medicine and surgery
Authors: Roger Dobson
Journal: BMJ (2004)

Leading jobs in cardiovascular medicine and cardiac surgery in the United Kingdom are increasingly being filled by doctors from Italy, France, and Germany, says an editorial in the European Heart Journal by leading members of the two specialisms.

British doctors are being put off academic jobs by lack of flexibility in training and the rewards of private practice, says the article ( European Heart Journal 2004;25:1568-9).

“The pursuit of private practice, which generates enormous incomes among NHS physicians and surgeons, produces role models for junior doctors who aspire to material wealth as opposed to intellectual advance,” say the authors.

They say …
TCT-97 Standardized Risk Model for Predicting Long-Term Bleeding After Percutaneous Coronary Intervention
Authors: Praneet K. Sharma, Adnan K. Chhatriwalla, Paramdeep Baweja, Jae-Sik Jang, Kensey Gosch, Richard G. Bach, John Spertus
Journal: Journal of the American College of Cardiology (2014)
Resveratrol blocks Akt activation in angiotensin II- or EGF-stimulated vascular smooth muscle cells in a redox-independent manner
Authors: Cornelia E. Schreiner, Mario Kumerz, Julia Gesslbauer, Daniel Schachner, Helge Joa, Thomas Erker, Atanas G. Atanasov, Elke H. Heiss, Verena M. Dirsch
Journal: Cardiovascular Research (2010)

AimsResveratrol (RV), an antioxidant, inhibits angiotensin II (Ang II)-induced hypertrophy and Ang II- or epidermal growth factor (EGF)-induced Akt phosphorylation in rat vascular smooth muscle cells (VSMCs). Both signalling pathways are reported to utilize reactive oxygen species (ROS). The aim of this study was to show whether RV reduces the ROS level in Ang II- or EGF-activated VSMCs and whether reduction of ROS causes the impeded signalling towards Akt in the presence of RV.
TEMPORAL CHANGE OF ACTIVITY OF M. STERNOCLEIDOMASTOIDEUS AND M. TRAPEZIUS PARS DESCENDENS WHEN PERFORMING A HEADER AFTER FATIGUE OF THE TRUNK MUSCLES
Authors: S Becker, O Ludwig, J Kelm
Journal: British Journal of Sports Medicine (2013)

Introduction Precise recommendations on how to plan a training schedule for headers in soccer are rare. To ensure a clean technical and non-hazardous movement when heading the ball, specialized literature postulates the necessity of strengthening the muscles stabilizing the trunk. The question was how the muscles essential for headers would be working in non-fatigued and fatigued conditions. Therefore this study tried to record a potential temporal change of the maximum activity of m. sternocleidomastoideus (SCM) and m. trapezius pars descendens (TPD), after the muscles stabilizing the trunk (m. erector spinae and m. rectus abdominis) had been tired out by a treatment. Methods 12 nonprofessional soccer players were analyzed in a pre-post-test, performing straight headers using a pendulum header after a two footed take-off. The myoelectric potential of SCM and TPD was recorded with the help of telemetric surface electromyography. A foot pressure sensor was used to register the moment of take-off; an acceleration sensor was attached to the back of the head to register the ball contact. The treatment to tire out the trunk muscles included three abdominal excercises and two back excercises. After determining the moment of maximal activity within the defined time frame, that started at the point of take-off and ended at the point ob ball contact, pretest and posttest were compared with the help of a t-test to find out if any significant changes occured. Results The moments of maximum muscle activity of SCM and TPD changed heterogeneously but not significantly. Different muscular activation strategies could be identified. The maximum activity of TPD of four subjects occured in the posttest earlier (15% of the time frame). Three subjects showed an earlier activation of SCM (15% of the time frame), whereas five subjects didn't show any differences at all. Specialized literature postulated a co-contraction of SCM and TPD at the moment of ball contact, but this result could not be found in our tests. In general SCM was inactive at that point in time. Conclusion Beside the small number of subjects in the survey the reason for the heterogeneous and non-significant activation might be the redundant functioning of the muscles. The different temporal activations of TPD and SCM can be understood as inter-individual motor patterns. The stronger drawing back movement and acceleration originating in the throat-neck-region can be seen as a compensation of the tired trunk muscles. The reason for the missing co-contraction of SCM at the moment of ball contact, could be the standardized test methods with the help of an immovable pendulum header.
Hubris and Nemesis in heads of government
Authors: Robert L Leon
Journal: Journal of the Royal Society of Medicine (2007)

By couching the discussion of Blair and Bush in terms of hubris and nemesis, Lord Owen1 has avoided the pitfall of diagnosis from afar while still highlighting serious problems with the two world leaders (JRSM November 2006). He does dip his toe into psychodynamics citing Freud and Justin Frank, but, by and large, he sticks to discussing behaviour and its relation to hubris and power.

As a politician, Lord Owen is qualified to discuss the political leaders he has encountered. As a physician, should he be making medical judgments on political leaders? Simon Wessely has questions about this and about whether or not psychiatrists should venture beyond the consulting room.2

Should psychiatrists limit their judgments to patients they have examined? The American Psychiatric Association says ‘yes’ and Dr Wessely cites data to support that view. But the question remains, can psychiatrists and neuroscientists, with the help of philosophers, provide useful insights that contribute to the understanding of leaders and their followers?

I believe that we should try. We should bring whatever scientific data there may be to counter ideology, blind faith and the intoxicating effects of power. It is true hubris often comes with power. Even though we do not have a psychiatric diagnosis for hubris, it is a psychological entity and as such should potentially be understood by science, as are other psychological phenomena.

We do not diagnose those that we have not personally examined and we cannot diagnose an entire population, but perhaps we can bring clinical and scientific insights to help understand destructive behaviour

As scientists and clinicians, we too must guard against hubris. Hopefully our colleagues will help us with that. JRMS should be applauded for exploring the issue.
Endothelin receptor subtypes in resistance arteries from humans and rats
Authors: L.-Y. Deng, J.-S. Li, E. L Schiffrin
Journal: Cardiovascular Research (1995)

Endothelins bind to different receptor subtypes identified as ETA and ETB receptors, ETA receptors are present on smooth muscle cells of blood vessels. ETB receptors seem to predominate on endothelial cells of blood vessels, but may also be present on smooth muscle in some vascular beds. The aim of this study was to investigate the distribution of ETA and ETB receptors in human and in rat resistance arteries.Contractile responses to endothelin-1 and to the ETB agonist sarafotoxin S6c were investigated in human subcutaneous resistance arteries and in rat mesenteric resistance arteries mounted on a wire myograph.Contractile responses to endothelin-1 were significantly reduced by the ETA selective antagonists BQ123 or BQ610 in human resistance arteries, and were almost abolished by the antagonists in rat arteries. The ETB agonist sarafotoxin S6c induced smaller responses than endothelin-1. When responses to sarafotoxin S6c were obtained in the presence of BQ610, the relatively small contractile response remained. It was slightly enhanced if the responses were obtained in the presence of the nitric oxide synthase inhibitor L-NAME or after removal of the endothelium.Vasoconstrictor ETB receptors appear to be present in resistance vessels isolated from subcutaneous fat in humans and from the mesentery in rats, but their contribution to endothelin mediated constriction is small, particularly in rat resistance arteries. ETA receptors appear to be the more important endothelin receptor subtype in the human and rat resistance arteries examined.
Increasing Incidence of Endometrial Cancer in the United States
Authors: Noel S. Weiss, Daniel R. Szekely, Donald F. Austin
Journal: New England Journal of Medicine (1976)

Data from eight areas in the United States served by population-based cancer reporting systems indicate that, after many years of relative stability, incidence rates of endometrial cancer have risen sharply in the 1970's. In some areas the amount of the increase has exceeded 10 per cent per year. The incidence among middle-aged women has changed most (by 40 to 150 per cent between 1969 and 1973, depending on the area), but rates have increased in younger women and the elderly as well.
The Impact of ACE Inhibitors or Angiotensin II Type 1 Receptor Blockers on the Development of New-Onset Type 2 Diabetes
Authors: Effie L. Gillespie, C. Michael White, Michael Kardas, Michael Lindberg, Craig I. Coleman
Journal: Diabetes Care (2005)

Angiotensin II has been shown to increase hepatic glucose production and decrease insulin sensitivity. Patients who utilize either an ACE inhibitor (ACEI) or angiotensin receptor blocker (ARB) may experience a decreased incidence of new-onset type 2 diabetes.Three reviewers conducted a systematic literature search of Medline, EMBASE, CINAHL, and the Cochrane Library (1966 to present) to extract a consensus of trial data involving an ACEI or ARB with an end point of new-onset type 2 diabetes. Studies were included if they were randomized controlled trials verses placebo/routine therapy. A random-effects model was utilized. Subgroup and sensitivity analyses were conducted.Eleven trials were identified, including 66,608 patients. An ACEI or ARB prevented new-onset type 2 diabetes (odds ratio 0.78 [95% CI 0.73-0.83]). The influence of either an ACEI (six trials) or an ARB (five trials) alone on new-onset type 2 diabetes was similar (0.79 [0.71-0.89] and 0.76 [0.70-0.82], respectively). Regardless of indication for use, hypertension (seven trials), coronary artery disease (two trials), or heart failure (two trials), reductions in new-onset type 2 diabetes were maintained (0.79 [0.72-0.85], 0.76 [0.60-0.95], and 0.70 [0.50-0.96], respectively). No statistical heterogeneity was observed for any evaluation (P > 0.1 for all comparisons). ACEIs and ARBs did not reduce the odds of mortality, cardiovascular, or cerebrovascular events versus control therapy among all of these studies combined or the hypertension trials. ACEIs and ARBs did reduce the odds of these outcomes among the coronary artery disease studies versus control therapy.ACEIs or ARBs may decrease patients' odds of developing new-onset type 2 diabetes but does not reduce the odds of mortality, cardiovascular, or cerebrovascular outcomes over the study follow-up periods among patients with hypertension.
Prospective efficacy trial of anti-HCV screening of donors to prevent postransfusion hepatitis
Authors: A González, JI Esteban, C Martin-Vega, JM Hernandez, P Madoz, E Mun̄iz, J Torras, J Buenestade, J Enriquez, R Plá, R Esteban, J Guardia
Journal: Journal of Hepatology (1990)
1121. Osteogenic Growth Peptide Preferentially Enhances Trabecular Bone Mass
Authors: Todd E. Meyerrose, Elisheva Smith, Jan A. Nolta, Baruch Frenkel
Journal: Molecular Therapy (2005)

Osteogenic growth peptide (OGP) is a bone anabolic protein synthesized by leaky ribosomal scanning through an imperfect initiator sequence within histone H4 to a perfect alternative site at codon 85. OGP has been shown previously to be upregulated following bone fracture or injury, as well as following massive blood loss. These observations prompted us to investigate the role of OGP in bone formation and endosteal vascular niche interactions.
Race/Ethnicity, Serum 25-Hydroxyvitamin D, and Heart Disease
Authors: Keith C. Norris, Sandra F. Williams
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Large Renal Cell Carcinoma Isometabolic With Normal Liver on F-18 FDG PET Scan
Authors: H K. Cheow, J A. Joseph, K K. Balan
Journal: Clinical Nuclear Medicine (2004)

Positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) is a very effective imaging modality in the diagnosis, staging, and monitoring of a variety of malignant conditions. The principle of imaging is based on the enhanced utilization of glucose by cancer. In this report, we describe a patient with renal cell carcinoma who showed FDG uptake isometabolic to normal liver.
Cholesterol and Violence: Is There A Connection?
Authors: Mark R. Goldstein
Journal: Annals of Internal Medicine (1998)

Letters15 October 1998Cholesterol and Violence: Is There A Connection?Mark R. Goldstein, MDMark R. Goldstein, MDCrozer-Keystone HealthPlex; Springfield, PA 19064Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-8-199810150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Before breakfast, as I was reading Dr. Golomb's intriguing article [1], I realized which connection between cholesterol and violence actually exists. I was quite angry about the article's conclusions.The connection between low cholesterol and aggressive behavior may be a connection between hunger and aggressive behavior. In some instances, low cholesterol levels may be a surrogate marker for being chronically underfed. From an evolutionary standpoint, it makes sense. In times of low food supply, primitive humans were hungry, probably had low cholesterol levels, and were aggressive enough to hunt food for survival.Did you ever watch children ...References1. Golomb BA. Cholesterol and violence: is there a connection? Ann Intern Med. 1998; 128:478-87. Google Scholar2. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 1994; 344:1383-9. Google Scholar3. Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, MacFarlane PW, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med. 1995; 333:1301-7. Google Scholar4. Sacks FM, Pfeffer MA, Moye LA, Rouleau JL, Rutherford JD, Cole TG, et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial Investigators. N Engl J Med. 1996; 335:1001-9. Google Scholar5. The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA. 1984; 251:365-74. Google Scholar Author, Article, and Disclosure InformationAffiliations: Crozer-Keystone HealthPlex; Springfield, PA 19064 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCholesterol Metabolism: A Potential Therapeutic Target in Glioblastoma 15 October 1998Volume 129, Issue 8Page: 668-669KeywordsBehaviorBloodChildrenCholesterolCoffeeDietDrugsEatingFoodStatins Issue Published: 15 October 1998 CopyrightCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Abstract 1010: Paradoxic effects of metformin on endothelial cells and angiogenesis
Authors: Antonino Bruno, Katiuscia Dallaglio, Anna Rita Cantelmo, Alessia I. Esposito, Luca Ruggiero, Stefania Orecchioni, Angelica Callieri, Francesco Bertolini, Ulrich Pfeffer, Douglas M. Noonan, Adriana Albini
Journal: Cancer Research (2014)

Abstract Epidemiological evidence has suggested that metformin, an anti-hyperglycemic agent commonly used in the treatment of type 2 diabetes, is a potential cancer preventive agent. Anti-angiogenesis represents a key mechanism in cancer prevention, a concept termed angioprevention. Since conflicting data concerning the anti-angiogenic action of metformin are emerging, we elucidate the effects of metformin, on endothelial and tumor cells as well as on angiogenesis using in vitro, in vivo and transcriptomic approaches. We show that metformin inhibits endothelial cell ability to organize into capillary-like networks; this effect is partially dependent on the energy sensor AMPK. Gene expression and proteins profiling revealed paradoxic effects on several angiogenesis associated factors. We found induction of VEGF, COX2 and CXCR4 at the mRNA level and down-regulation of ADAMTS1. Interestingly, antibody array analysis showed essentially opposite regulation of numerous angiogenesis-associated proteins in endothelial and breast cancer cells. We also show that endothelial production of cytochrome p450 family member CYP1B1 was up-regulated by tumor cell supernatants, while metformin blocked this effect by acting on AMPK. The metformin anti-angiogenic activity was exerted through inhibition of ERK1/2 activation, even in the presence of VEGF, while blocking AMPK activity abrogated this effect. Metformin inhibited angiogenesis induced by VEGF in matrigel pellets in vivo and contrasted the increase in microvessel density in obese mice on a high fat diet. Further, it down-regulated the number of endothelial precursor cells from white adipose tissue in obese mice. Our data show that metformin has an anti-angiogenic activity in vitro and in vivo, which is associated with a contradictory enhancement of chemokines and other inflammatory pro-angiogenic mediators, as well as a different regulation in endothelial and breast cancer cells. Citation Format: Antonino Bruno, Katiuscia Dallaglio, Anna Rita Cantelmo, Alessia I. Esposito, Luca Ruggiero, Stefania Orecchioni, Angelica Callieri, Francesco Bertolini, Ulrich Pfeffer, Douglas M. Noonan, Adriana Albini. Paradoxic effects of metformin on endothelial cells and angiogenesis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1010. doi:10.1158/1538-7445.AM2014-1010