tbuckley/cabot-search huggingface dataset:
Acupuncture needle scars
Authors: P.D. Pigatto, G. Guzzi
Journal: British Journal of Dermatology (2004)

A 36‐year‐old woman with hyperthyroidism without exophthalmos presented with unusual bilateral round scars. There were two atrophic scars which measured 1·5 cm in diameter. Examination of her neck showed a mild goitre. She had consulted a Chinese acupuncturist physician and underwent a series of acupuncture treatment. The treatment consisted of stimulation of Chinese acupoints, particularly the bilateral Stomach.10–Shuitu point (St 10) (Fig. 1), with a hot needle, 20 times. Follow‐up clinical and haematological assessments were done several months after the acupuncture treatment but there had been no improvement in her hyperthyroidism. She has visible, unaesthetic scars due to the acupuncture treatment.
Methotrexate induced skin necrosis: a drug interaction with amiodarone?
Authors: N. J. Reynolds, S. K. Jones, J. Crossley, R. R. Harman
Journal: BMJ (1989)

able to give full informed consent when prescribed transurethral resection for prostatic hvpertrophv.Are they being denied the information that such an approach carries certain disadvantages, or would full disclosures of this kind be reserved only for patients randomised into clinical trials?If so, this suggests that a double standard exists already and that ethical committees, instead of merely scrutinising the protocols of randomised controlled trials, should also be scrutinising the amount of information that patients are being given outside clinical trials.To deny a patient the knowledge of an appreciable and perhaps avoidable risk of mortality by the uncritical adoption of transurethral resection also raises important ethical issues.
Neonatal respiratory distress caused by aspiration of a vaginal tablet containing prostaglandin.
Authors: S Andersson, R Paetau, M Hallman, H Vapaatalo, O Ylikorkala
Journal: BMJ (1987)

Cyst infection in acquired renal cystic diseaseCystic degeneration of the kidney in patients with advanced renal failure is common'; whether cysts can harbour infection remains to be shown.2We report on three cases of infected cysts in acquired renal cystic disease. Case reportsCase I-A 60 year old man was admitted to hospital because of uraemia, hypertension, recurrent fever, and leucocytosis.The plasma concentration of creatinine was 821 !umol/l, and a urine culture was positive for Escherichia coli.Ultrasonography showed normal sized hyperechogenic kidneys with more than three 1-2 cm cysts in each.There was a 6 cm cyst that was hyperechogenic at the upper pole of the left kidney.Renal computed tomography confirmed the presence of bilateral multiple cysts.A thick wall, enhanced by contrast infusion, was seen around a slightly dense cyst on the upper pole of the left kidney (figure).R | L Both kidneys are occupied by low density cysts.A thick wall, enhanced by contrast infusion, is seen around a slightly dense cyst (arrow).Renal biopsy showed chromic glomerulonephiritis with mesangial deposits of C3.Percutaneous aspiration of the cyst yielded purulent fluid which was positive for E coli.He was given tobramycin; the fever disappeared, and the urine became sterile and the white cell count normal.Case 2-A 60 year old woman with renal failure secondary to dia-betic nephropathy was admitted to hospital because of fever and dysuria.Plasma creatinine concentration was 482 limolIl,'she had leucocytosis and pyuria, and a urine culture was positive forE coli.A radiograph of the abdomen showed air in the left renal profile.Ultrasonography showed multiple renal cysts and a hyperechogenic parenchyma.Computed tomography confirmed the presence of the cysts and suggested an abscess at the lower renal pole and perirenal space of the left kidney.We removed a cyst, the fluid of which was infected by E coli.Tobramycin was administered and the white cell count became normal and the urine sterile.Case 3-A 78 year old woman presented with uraemia and creatinine values of 1120 iLmol/I and was started on haemodialysis.Ultrasonography showed small, hyperechogenic kidneys with multiple cysts.On admission she had a fever with no apparent cause.No urine cultures were available.She died a few days later of haemorrhage of the upper digestive tract.Necropsy showed two end stage kidneys with multiple corticomedullary cysts; an infected cortical cyst was found in the left kidney.
Hospital Medical Ethics Committees: A Review of Their Development
Authors: Fred Rosner
Journal: JAMA (1985)

RAPID advances in biomedical technology have necessitated that physicians, nurses, and other health personnel be introspective in what they ultimately will do with patients who are terminally ill or have physical handicaps that will lead to a life that is far from normal. The new technology has dictated the need to reexamine and redefine ethical and moral values. Many physicians are now more concerned about ethical and moral decisions than they have been in the past. Despite this growing concern with moral values, the medical community is being labeled as cold, scientific, unethical, and uncaring by people in the political, scientific, and business communities. This article, which describes the historical development of hospital ethics committees, is intended to show that medical practitioners are becoming more aware that they must approach medical care in an ethical manner similar to the way they approach other social issues. <h3>The Earliest Hospital Ethics Committees</h3>
Abstract 2073: Curcumin analog 27 induced reactive oxygen species mediate loss of androgen receptor protein expression in human prostate cancer cells
Authors: Alexandra M. Fajardo, Debra A. MacKenzie, Lorraine M. Deck, David L. Vander Jagt, Todd A. Thompson, Marco Bisoffi
Journal: Cancer Research (2011)

Abstract The androgen receptor (AR) is an established therapeutic target for prostate cancer. Therefore, agents that down-regulate AR expression may be effective for prostate cancer therapy. We show that the experimental therapeutic agent, curcumin analog 27 (ca27), induces the down-regulation of the AR in LNCaP and LAPC4 prostate cancer cell lines. Treatment with ca27 selectively inhibits AR mRNA expression, whereas ca27 did not alter mRNA levels for other steroid hormone receptors, such as the glucocorticoid receptor. In addition, ca27 decreases AR protein expression and increases AR protein ubiquitination within 3 hours. However, this rapid decrease in AR protein expression by ca27 is not mediated by proteasomal degradation. Interestingly, we observed an induction of reactive oxygen species (ROS) within 1 to 2 hours of ca27 treatment, which precedes AR degradation, leading to the hypothesis that ca27 mediates AR degradation through a cellular oxidative stress mechanism of action. In support of this hypothesis, the degradation of the AR following ca27 treatment is abrogated in the presence of the antioxidant, N-acetyl cysteine. Treatment with ca27 did not reduce cell viability by 24 hours suggesting that the increase in ROS and the inhibition of AR protein expression are independent of cell death. To further evaluate the cellular response to oxidative stress by ca27, we investigated the induction of a critical transcription factor activated as a cellular redox sensor, Nrf2. Treatment with ca27 lead to the increased transcriptional activation of Nrf2 as measured by an Nrf2-luciferase reporter assay. The ca27-induced Nrf2 activation was further supported by increased mRNA expression of the Nrf2-regulated genes NAD(P)H quinone oxidoreductase 1 and aldoketoreductase 1C1. This study begins to identify the mechanism of action of ca27-mediated AR protein degradation with the overall goal of gaining insight into targeting ROS-mediated AR down-regulation as a strategy for prostate cancer therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2073. doi:10.1158/1538-7445.AM2011-2073
Kokoschka in Love, 1914
Authors: Floyd Skloot
Journal: JAMA (1996)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hyperglycemia is an important predictor of impaired coronary flow before reperfusion therapy in ST-segment elevation myocardial infarction
Authors: Jorik R. Timmer, Jan Paul Ottervanger, Menko-Jan de Boer, Jan-Henk E. Dambrink, Jan C.A. Hoorntje, A.T. Marcel Gosselink, Harry Suryapranata, Felix Zijlstra, Arnoud W.J. van't Hof
Journal: Journal of the American College of Cardiology (2005)
The Pregnant Kidney
Authors: Leonard B. Berman
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Improving the performance of the English NHS
Authors: C. Ham
Journal: BMJ (2010)

Systems of care are needed to build on progress to date

The NHS in England has been a laboratory for healthcare reform under the Labour government. While much has been achieved during Labour’s stewardship, particularly major reductions in waiting times for treatment and improvements in areas of clinical priority such as cardiac and cancer care, there is a great deal of unfinished business. The agenda for the future includes giving high priority to prevention, shifting care closer to home, and grasping the nettle of acute hospital reconfiguration to reduce duplication and improve outcomes.

As this agenda is taken forward, a crucial question is: what approach should be used to bring about improvements in performance? Three reports commissioned by the Department of Health during Lord Darzi’s “Next Stage Review” shed light on this question. The reports have recently been released after a Freedom of Information Act request, and they offer important insights into the means used by the government to bring about change in the NHS in England.1 2 3

Although each report makes specific recommendations in line with its terms of reference, the consistent and recurrent themes in all three are of greatest interest. These themes include the destabilising effects of constant organisational restructuring, the negative consequences of a command and control style of leadership, and the lack of …
WHO launches campaign to make drugs safer for children
Authors: Geoff Watts
Journal: BMJ (2007)

An initiative from the World Health Organization has been launched to make drugs as simply and safely available to children as they are to adults.

Speaking last week at the launch in London, WHO’s assistant director general, Howard Zucker, said that “there is a gap between the availability of children’s medicines and the actual need. That gap is global and must be addressed.”

The problem is not new. “It’s a reality we’ve lived with for many years,” Dr Zucker admitted. Most drugs are developed for and tested in adults. Less than a third come in a form appropriate for children.

As a result, many children are treated using drugs that are effectively unlicensed. Medical staff may be obliged to …
Abstract 3730: Akt activity is suppressed by doxorubicin through downregulation of ErbB receptors and its enhanced activity is associated with higher sensitivity to doxorubicin in breast cancer
Authors: Amane Harada, Chihiro Suminaka, Tomoko Oyama, Keigo Gohda, Hideki Ishihara, Seung Jin Kim, Shinzaburo Noguchi
Journal: Cancer Research (2010)

Abstract Anthracyclines are the backbone of breast cancer therapy and benefit patients in both the adjuvant and metastatic setting whereas they are effective for 50-60% of breast cancer patients and cause substantial morbidity and occasional life-threatening toxic effects. For these reasons, it has been eagerly anticipated to develop diagnostic markers which can predict efficacy of the treatment. HER2 amplification or overexpression of its protein (HER2 positivity) has been shown to be associated with relative benefit from anthracycline-based chemotherapy (Gennari A. et al., J. Natl. Cancer Inst, 100, 14-20, 2008). However, HER2 is positive in 15-25% of breast tumor tissues and no clear biological mechanism between HER2 positivity and action of anthracyclines has been reported. In this study, we have shown that doxorubicin exerts its anti-tumor activity through inhibiting ErbBs-Akt signal pathway. Promoted activity of Akt was associated with not only HER2 but EGFR overexpression and responsiveness to doxorubicin in human breast cancer cell lines. As well as doxorubicin, PI3 kinase inhibitor caused growth inhibition and apoptosis in cells with promoted Akt activity more significantly than cells with weakly activated Akt. Doxorubicin-induced cytotoxic stress induced internalization and degradation of ErbBs followed by inactivation of Akt. This was confirmed with the observation that doxorubicin caused decrease in the amount of immunocomplex formed between HER3 and p85, PI3 kinase regulatory subunit. These data indicate that cancer cells with ErbBs overexpression and promoted Akt activity are dependent on activities of these factors for their growth and survival, and doxorubicin inhibits the ErbBs-Akt signal pathway through inducing downregulation of ErbB receptors. Furthermore, we found that highly phosphorylated Akt in tumors corresponds to improved recurrence-free survival in breast cancer patients treated with anthracycline-based adjuvant chemotherapy relative to weakly phosphorylated Akt. Taken together, we provide mechanistic insight into molecular basis of correlation between HER2 positivity and sensitivity to anthracyclines, and propose a new possibility that Akt activity is a useful predictor of response to anthracycline-based chemotherapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3730.
Protection by superoxide dismutase and catalase in the isolated rat heart reperfused after prolonged cardioplegia: a combined study of metabolic, functional, and morphometric ultrastructural variables
Authors: K. YTREHUS, S. GUNNES, R. MYKLEBUST, O. D MJOS
Journal: Cardiovascular Research (1987)

Journal Article Protection by superoxide dismutase and catalase in the isolated rat heart reperfused after prolonged cardioplegia: a combined study of metabolic, functional, and morphometric ultrastructural variables Get access KIRSTI YTREHUS, KIRSTI YTREHUS From the Institute of Medical Biology, University of Tromsø, Tromsø, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar SIGURD GUNNES, SIGURD GUNNES From the Institute of Medical Biology, University of Tromsø, Tromsø, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar REIDAR MYKLEBUST, REIDAR MYKLEBUST From the Institute of Medical Biology, University of Tromsø, Tromsø, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar OLE D MJØS OLE D MJØS From the Institute of Medical Biology, University of Tromsø, Tromsø, Norway Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 21, Issue 7, July 1987, Pages 492–499, https://doi.org/10.1093/cvr/21.7.492 Published: 01 July 1987 Article history Received: 15 September 1986 Accepted: 06 January 1987 Published: 01 July 1987
Fewer People to Face Penalty for Lacking Health Coverage
Authors: Tracy Hampton
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Editorial: Mesenteric arterial insufficiency
Authors: H. H. Hussey
Journal: JAMA (1976)

Pathologically, atherosclerosis is a spotty disease of the arteries, both in the manner of affecting vessels individually and in its distribution among arteries generally. For the latter reason, in one group of persons (the largest group), coronary artery syndromes predominate, while in other groups, vascular involvement first affects other organs—the brain, the aorta, the lower extremities, the intestines. Atherosclerosis of the mesenteric arteries provokes a variety of syndromes, depending on the extent of involvement, the rapidity with which it develops, and other factors. When atherosclerosis is extensive and suddenly complicated by thrombosis, intestinal infarction results in the clinical manifestations of an acute abdominal catastrophe. Then, whether or not the diagnosis has been confirmed by arteriography, surgical exploration of the abdomen almost always follows. At that time, the surgeon is faced with a difficult decision, namely, whether to do nothing, to resect infarcted bowel (a procedure leading to high mortality), or
No Papanicolaou Tests in Women Younger Than 21 Years or After Hysterectomy for Benign Disease
Authors: Nancy Morioka-Douglas, Paula J. Adams Hillard
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Colonic manometry in children with chronic intestinal pseudo-obstruction.
Authors: C Di Lorenzo, A F Flores, S N Reddy, W J Snape, G Bazzocchi, P E Hyman
Journal: Gut (1993)

Pressure changes were evaluated in the transverse, descending, and rectosigmoid colon of 30 children with chronic intestinal pseudo-obstruction. Twenty two had severe lifelong constipation and eight had symptoms suggesting a motility disorder exclusively of the upper gastrointestinal tract. Based on prior antroduodenal manometry, 24 children were diagnosed as having a neuropathic and six a myopathic form of intestinal pseudo-obstruction. On the day of study, endoscopy was used to place a manometry catheter into the transverse colon and intraluminal pressure was recorded for more than four hours. After a baseline recording, we gave a meal to assess the gastrocolonic response. Colonic contractions were noted in 24 children. The six children with no colonic contractions had a hollow visceral myopathy and constipation. In the children with colonic contractions, fasting motility did not differentiate children with and without constipation. After the meal, in all eight children without constipation there was (1) an increase in motility index (3.2 (SEM 0.3) mm Hg/min basal v 8.4 (SEM 1.1) mm Hg/min postprandial; p &lt; 0.001), and (2) at least one high amplitude propagated contraction (HAPC). In the 16 constipated children with colonic contractions the motility index did not significantly increase after the meal (2.1 (SEM 0.3) mm Hg/min basal v 3.1 (SEM 0.4) mm Hg/min postprandial) and 12 of them had no HAPCs (p &lt; 0.01 v group without constipation). In summary, in children with a clinical diagnosis of chronic intestinal pseudo-obstruction, constipation is associated with absence of HAPCs, and the gastrocolonic response or with total absence of colonic contractions. It is concluded that studies of colonic manometry are feasible in children and may document discrete abnormalities in those with intestinal pseudo-obstruction with colonic involvement.