Nitric Oxide and Impaired Oxygenation before and after Liver Transplantation
Authors: Shinji Teramoto, Takeshi Matsuse, Yasuyoshi Ouchi
Journal: Annals of Internal Medicine (1999)

Letters6 July 1999Nitric Oxide and Impaired Oxygenation before and after Liver TransplantationShinji Teramoto, MD, Takeshi Matsuse, MD, and Yasuyoshi Ouchi, MDShinji Teramoto, MDTokyo University Hospital; Tokyo 113-8655, Japan (Teramoto)Tokyo University Hospital; Tokyo 113-8655, Japan (Matsuse)Tokyo University Hospital; Tokyo 113-8655, Japan (Ouchi), Takeshi Matsuse, MDTokyo University Hospital; Tokyo 113-8655, Japan (Teramoto)Tokyo University Hospital; Tokyo 113-8655, Japan (Matsuse)Tokyo University Hospital; Tokyo 113-8655, Japan (Ouchi), and Yasuyoshi Ouchi, MDTokyo University Hospital; Tokyo 113-8655, Japan (Teramoto)Tokyo University Hospital; Tokyo 113-8655, Japan (Matsuse)Tokyo University Hospital; Tokyo 113-8655, Japan (Ouchi)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-1-199907060-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Rolla and colleagues (1) reported that the increase in exhaled nitric oxide (NO) concentration after liver transplantation was correlated with improvement in oxygenation. Their conclusion that NO is an important mediator of impaired oxygenation in patients with cirrhosis is supported by other data (2, 3). However, their conclusion that "most cases of abnormal oxygenation in patients with cirrhosis are reversible after transplantation" may not be true.First, Rolla and colleagues' patients were not always hypoxemic, and the authors did not indicate the reversibility of abnormal oxygenation in patients with cirrhosis. Second, the hypoxemic patients with liver cirrhosis ...References1. Rolla G, Brussino L, Colagrande P, Scappaticci E, Morello M, Bergerone S, et al . Exhaled nitric oxide and impaired oxygenation in cirrhotic patients before and after liver transplantation. Ann Intern Med. 1998;129:375-8. LinkGoogle Scholar2. Rolla G, Brussino L, Colagrande P, Dutto L, Polizzi S, Scappaticci E, et al . Exhaled nitric oxide and oxygenation abnormality in hepatic cirrhosis. Hepatology. 1997;26:842-7. CrossrefMedlineGoogle Scholar3. Matsumoto A, Ogura K, Hirata Y, Kakoki M, Watanabe F, Takenaka K, et al . Increased nitric oxide in the exhaled air of patients with decompensated liver cirrhosis. Ann Intern Med. 1995;123:110-3. LinkGoogle Scholar4. Durand P, Baujard C, Grosse AL, Gomola A, Debray D, Dousset B, et al . Reversal of hypoxemia by inhaled nitric oxide in children with severe hepatopulmonary syndrome, type 1, during and after liver transplantation. Transplantation. 1998;65:437-9. CrossrefMedlineGoogle Scholar5. Whyte MK, Hughes JM, Peters AM, Ussov W, Patel W, Burroughs AK. Analysis of intrapulmonary right to left shunt in the hepatopulmonary syndrome. J Hepatol. 1998;29:85-93. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Tokyo University Hospital; Tokyo 113-8655, Japan (Teramoto)Tokyo University Hospital; Tokyo 113-8655, Japan (Matsuse)Tokyo University Hospital; Tokyo 113-8655, Japan (Ouchi) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoExhaled Nitric Oxide and Impaired Oxygenation in Cirrhotic Patients before and after Liver Transplantation Giovanni Rolla , Luisa Brussino , Paola Colagrande , Ermanno Scappaticci , Mara Morello , Serena Bergerone , Antonio Ottobrelli , Elisabetta Cerutti , Salvatore Polizzi , and Caterina Bucca Nitric Oxide and Impaired Oxygenation before and after Liver Transplantation Giovanni Rolla , Luisa Brussino , and Paola Colagrande Metrics Cited byThe Mechanism of Hypoxemia in Liver Disease With Pulmonary HypertensionCarcinoid-Related Intrapulmonary Shunting May Be Associated With Increased Production of Nitric Oxide 6 July 1999Volume 131, Issue 1Page: 69KeywordsAttentionCirrhosisLiver diseasesLiver transplantationLung transplantationLungsNitric oxideOxygenPortal hypertensionTransplantation Issue Published: 6 July 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...