tbuckley/cabot-search huggingface dataset:
Incidence of Rapid Resolution of Defects on Stress Thallium Scans
Authors: P TODD MAKLER, DAVID M. McCARTHY, HAROLD GOLDSTEIN, MICHAEL J. EYMONTT, ABASS ALAVI
Journal: Clinical Nuclear Medicine (1982)

A prospective study was performed to determine the frequency with which defects on stress thallium images undergo rapid resolution. Analysis of paired views showed that 15% of the defects present in anterior views resolve in less than 30 minutes. This study documents the loss of sensitivity that can occur if imaging does not begin promptly after injection.
A genetic analysis of lupus
Authors: A. N. Theofilopoulos, D. H. Kono
Journal: Allergy (2002)

Systemic lupus erythematosus (SLE) is a complex multigenic inherited disease with susceptibility determined by a combination of genetic, environmental and stochastic factors. Although not yet defined, recent technical advances have provided the means to dissect the component genetic contributions of polygenic traits. We have applied such approaches to mouse models of spontaneous SLE and, in this report, summarize our genome wide mapping studies that identified loci predisposing to several major lupus‐related traits. Through the generation and study of interval congenic lines, precise mapping, and screening of candidate genes, identification of the specific genes and mechanisms associated with some of the major loci is currently being pursued.
Unusual Case of Emphysematous Cystitis Seen on FDG PET/CT
Authors: John L. Mikell, Keith Herr, Bruce J. Barron
Journal: Clinical Nuclear Medicine (2013)

Emphysematous cystitis is a rare condition requiring immediate aggressive medical attention. Here, we describe a very unusual case of emphysematous cystitis seen on FDG PET/CT. This finding was discovered in an 84-year-old man undergoing FDG PET/CT to monitor a known diagnosis of IgG4-related nodular sclerosis. Images revealed gas within the bladder wall and an anterior gas-filled bladder diverticulum. The patient subsequently developed sepsis with cultures revealing Escherichia coli. This case highlights the importance of recognizing this finding on varied imaging modalities, as life-threatening complications may arise from this condition.
AN ADDRESS ON GOITRE
Authors: H. J. Boyd
Journal: BMJ (1919)

One of the most notable baeteriologioal differences between the epidemic occurring in Egypt and Palestine and in Europe has been the almost complete absence of bacilli oorresponding to the Pfeiffer type.During examination of film preparations of sputa at all stages of the disease, Gram-negative micro-bacilli of Pfeiffer type were only observed in twelve cases, and in three cases only has anything corresponding to the Bacillue influenzae been isolated in culture, althouglh media recommended by observers in England as specially suit- able for the isolation of this micro-organism, including that of Matthews,* and the "1 K " 8 medium 'quoted by Fildes, Baker, and Thompson, have been repeatedly used.I find also on inquiry that these results as regards the almost complete absence of B. snflue"zae correspond with those of other laboratory workers in the distriet.Many post-mortem examinations have been made, but as results coincide with those detailed by other observers, they have been omitted from this article.In this con: nexion I would like to thaak Major P.
Occasional notes: Doctor did Atkins
Authors: Daniel Wheeler
Journal: BMJ (2004)

“ W e've got another one, Mary.” So said the lady behind the League of Friends' tea bar to her colleague when I asked for a smoked mackerel salad rather than the usual sausage sandwich and caramel slice. “That must be 12 now,” came the reply, “they're all doing it.” It was August 2003, and clearly I was just one of the many hospital tea bar regulars who, at the height of the hype, had forsaken carbohydrates and taken up the Atkins diet in a quest to be the next Jennifer Aniston. I had been shocked into action after a rare interaction with the bathroom scales gave me a nasty surprise and a quick calculation suggested my body mass index was nudging 35. …
Increasing the knowledge in managing hyperpigmentary disorders: a report from the Pigmentary Disorders Academy
Authors: J-P. Ortonne
Journal: British Journal of Dermatology (2006)

Journal Article Increasing the knowledge in managing hyperpigmentary disorders: a report from the Pigmentary Disorders Academy Get access J‐P. Ortonne J‐P. Ortonne University of Nice‐Sophia Antipolis, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue s1, 1 December 2006, Pages 1–2, https://doi.org/10.1111/j.1365-2133.2006.07587.x Published: 01 December 2006
Moderate Intake of n-3 Fatty Acids for 2 Months Has No Detrimental Effect on Glucose Metabolism and Could Ameliorate the Lipid Profile in Type 2 Diabetic Men: Results of a controlled study
Authors: Jing Luo, Salwa W Rizkalla, Hubert Vidal, Jean-Michel Oppert, Claude Colas, Abdelghani Boussairi, Michele Guerre-Millo, Anne-Sophie Chapuis, Annie Chevalier, Georges Durand, Gérard Slama
Journal: Diabetes Care (1998)

OBJECTIVE To evaluate the effect of a moderate dose of fish oil on glycemic control and in vivo insulin action in type 2 diabetic men with elevated plasma triacylglycerols and to determine the effect of the same treatment on gene expression of GLUT4, lipoprotein lipase (LPL), and hormone-sensitive lipase (HSL) in the abdominal adipose tissue. RESEARCH DESIGN AND METHODS A total of 12 type 2 diabetic men were randomly allocated to 2 months of 6 g daily of either fish oil or sunflower oil, separated by a 2- month washout interval, in a double-blind crossover design. RESULTS For glucose metabolism, 2 months of fish oil supplementation compared with sunflower oil led to similar fasting plasma insulin, glucose, and HbA1c. Basal hepatic glucose production did not increase after fish oil. There was no difference in insulin suppression of hepatic glucose production nor in insulin stimulation of whole-body glucose disposal measured by the euglycemic-hyperinsulinemic clamp. Fish oil did not ameliorate the low mRNA level of GLUT4 in adipose tissue of these patients. For lipid profile, fish oil lowered plasma triacylglycerol more than sunflower oil (P &amp;lt; 0.05) and tended to increase the amount of mRNA of both LPL and HSL in adipose tissue. CONCLUSIONS A moderate dose of fish oil did not lead to deleterious effects on glycemic control or whole-body insulin sensitivity in type 2 diabetic men, with preserved triacylglycerol- lowering capacities.
ANGINA PECTORIS IN A YOUTH OF EIGHTEEN
Authors: S. Chaille Jamison
Journal: JAMA (1925)

History.  —M. S., a boy, aged 18, white, was admitted to the medical service of Mercy Hospital, March 12, 1925, at 6 p. m., complaining of agonizing pain over the whole surface of the chest and the epigastrium. This pain was not referred to the arms or to any other part of the body; it was constant, though it waxed and waned in intensity. He had suffered in this manner throughout the day, though not so intensely. There had been nothing unusual in his habits, diet, health or exercise to account either to himself or to his family for the occurrence of this seizure; he had never had a previous attack. During the few days preceding, there had been no symptoms of ill health, and this attack was ushered in with no symptoms except the pain.  March 3, the patient had been admitted to the surgical clinic of Mercy Hospital
A STUDY IN THE HEMATOLOGY OF NEURASTHENIA.
Authors: CHARLES HOWARD LODOR
Journal: JAMA (1901)

The title neurasthenia would seem to cover a pathologic condition far more widespread than the term itself might indicate. There is scarcely an organ or tissue in the body which does not show more or less deviation from the normal. In taking up its hematology, facts appear which of themselves are confusing and contradictory. One of the first symptoms noticeable in neurasthenia is the evident, anemia or, if not anemia, hemic change. In an able and suggestive article published in the<i>Medical Record</i>, June 25, 1898, Mary Putnam Jacobi points out that many neurasthenics, and also patients evidently anemic, have a very high blood count, and gives the history and count of several patients where the reds were over 5,500,000. One patient, a palid neurasthenic, had a red count of 6,660,000; whites, 37,777. Following suggestions of Dr. S. Weir Mitchell, Dr. J. K. Mitchell has made a very careful and
Cofilin Drives Cell-Invasive and Metastatic Responses to TGF-β in Prostate Cancer
Authors: Joanne Collazo, Beibei Zhu, Spencer Larkin, Sarah K. Martin, Hong Pu, Craig Horbinski, Shahriar Koochekpour, Natasha Kyprianou
Journal: Cancer Research (2014)

Cofilin (CFL) is an F-actin-severing protein required for the cytoskeleton reorganization and filopodia formation, which drives cell migration. CFL binding and severing of F-actin is controlled by Ser3 phosphorylation, but the contributions of this step to cell migration during invasion and metastasis of cancer cells are unclear. In this study, we addressed the question in prostate cancer cells, including the response to TGF-β, a critical regulator of migration. In cells expressing wild-type CFL, TGF-β treatment increased LIMK-2 activity and cofilin phosphorylation, decreasing filopodia formation. Conversely, constitutively active CFL (SerAla) promoted filipodia formation and cell migration mediated by TGF-β. Notably, in cocultures of prostate cancer epithelial cells and cancer-associated fibroblasts, active CFL promoted invasive migration in response to TGF-β in the microenvironment. Further, constitutively active CFL elevated the metastatic ability of prostate cancer cells in vivo. We found that levels of active CFL correlated with metastasis in a mouse model of prostate tumor and that in human prostate cancer, CFL expression was increased significantly in metastatic tumors. Our findings show that the actin-severing protein CFL coordinates responses to TGF-β that are needed for invasive cancer migration and metastasis.
Combining Etoposide and Dexrazoxane Synergizes with Radiotherapy and Improves Survival in Mice with Central Nervous System Tumors
Authors: Kenneth Francis Hofland, Annemette Vinding Thougaard, Marielle Dejligbjerg, Lars H. Jensen, Paul E.G. Kristjansen, Pia Rengtved, Maxwell Sehested, Peter Buhl Jensen
Journal: Clinical Cancer Research (2005)

The treatment of patients with brain metastases is presently ineffective, but cerebral chemoradiotherapy using radiosensitizing agents seems promising. Etoposide targets topoisomerase II, resulting in lethal DNA breaks; such lesions may increase the effect of irradiation, which also depends on DNA damage. Coadministration of the topoisomerase II catalytic inhibitor dexrazoxane in mice allows for more than 3-fold higher dosing of etoposide. We hypothesized that dexrazoxane combined with escalated etoposide doses might improve the efficacy of cerebral radiotherapy.Mice with cerebrally inoculated Ehrlich ascites tumor (EHR2) cells were treated with combinations of etoposide + dexrazoxane + cerebral radiotherapy. Similar chemotherapy and radiation combinations were investigated by clonogenic assays using EHR2 cells, and by DNA double-strand break assay through quantification of phosphorylated histone H2AX (gammaH2AX).Escalated etoposide dosing (90 mg/kg) combined with dexrazoxane (125 mg/kg) and cerebral radiotherapy (10 Gy x 1) increased the median survival by 60% (P = 0.001) without increased toxicity, suggesting that escalated etoposide levels may indeed represent a new strategy for improving radiotherapy. Interestingly, 125 mg/kg dexrazoxane combined with normal etoposide doses (34 mg/kg) also increased survival from radiotherapy, but only by 27% (P = 0.002). This indicates a direct dexrazoxane modulation of the combined effects of etoposide and radiation in brain tumors. Further, in vitro, concurrent dexrazoxane, etoposide, and irradiation significantly increased DNA double-strand breaks.Combining etoposide (high or normal doses) and dexrazoxane synergizes with cerebral radiotherapy and significantly improves survival in mice with central nervous system tumors. This regimen may thus improve radiation therapy of central nervous system tumors.
Robotic Urologic Surgery
Authors: Shahin Chandrasoma
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CYTOMEGALOVIRUS INFECTION AND DONOR/RECIPIENT HLA ANTIGENS: INTERDEPENDENT CO-FACTORS IN PATHOGENESIS OF VANISHING BILEDUCT SYNDROME AFTER LIVER TRANSPLANTATION
Authors: JohnG. O'Grady, Sheena Sutherland, Felicity Harvey, RoyY. Calne, GraemeJ.M. Alexander, PeterT. Donaldson, Bernard Portmann, Roger Williams
Journal: The Lancet (1988)
Case 31-1974
Authors: Richard C. Cabot, Robert E. Scully, Betty U. McNeely, Robert H. Schapiro, James J. Galdabini
Journal: New England Journal of Medicine (1974)

Presentation of CaseA 63-year-old man was admitted to the hospital because of gastrointestinal bleeding.Two and a half years previously painless jaundice developed. A laparotomy at another hospital disclosed a large mass in the head of the pancreas, with compression of the common bile duct; since the appearance was considered characteristic of carcinoma a biopsy specimen was not obtained. A Roux-en-Y cholecystojejunostomy was performed, and 5-fluorouracil was administered for the following year. The jaundice disappeared, and the patient felt improved, with a gain of 10 kg in weight. Eleven months before admission a celiac and superior mesenteric angiographic study . . .
Efficacy and Safely of a Topical Gel Formulation of Recombinant Human Platelet-Derived Growth Factor-BB (Becaplermin) in Patients With Chronic Neuropathic Diabetic Ulcers: A phase III randomized placebo-controlled double-blind study
Authors: T Jeffery Wieman, Janice M Smiell, Yachin Su
Journal: Diabetes Care (1998)

OBJECTIVE To compare the efficacy and safety of topically applied recombinant human platelet-derived growth factor-BB (rhPDGF-BB) (becaplermin) with placebo gel in patients with chronic diabetic neuropathic ulcers of the lower extremities. RESEARCH DESIGN AND METHODS This multicenter double-blind placebo-controlled phase 111 trial included 382 patients with type 1 or type 2 diabetes and chronic ulcers of at least 8 weeks' duration. After sharp debridement of the ulcer, patients were randomized to receive becaplermin gel 30 μg/g, becaplermin gel 100 μg/g, or placebo gel, in conjunction with a standardized regimen of good wound care until complete wound closure was achieved or for a maximum of 20 weeks. Moist saline-soaked gauze dressings were changed twice daily with study medication applied by patients or caregivers at the evening dressing change. Safety was assessed by monitoring adverse events (AEs) and by clinical laboratory evaluations. RESULTS Compared with placebo gel, becaplermin gel 100 μg/g significantly increased the incidence of complete wound closure by 43% (50 vs. 35%, P = 0.007) and decreased the time to achieve complete wound closure by 32% (86 vs. 127 days; estimated 35th percentile, P = 0.013). AEs reported during treatment or during a 3-month follow-up period were similar in nature and incidence across all treatment groups. CONCLUSIONS Becaplermin gel 100 μg/g, in conjunction with good wound care, significantly increased the incidence of complete wound closure and significantly reduced the time to complete closure of chronic diabetic neuropathic ulcers. The safety profile of becaplermin gel was similar to that of placebo gel.
High rates of multidrug-resistant Mycobacterium tuberculosis in Sinaloa State, Mexico
Authors: Jorge Zazueta-Beltran, Secundino Muro-Amador, Adrián Flores-Gaxiola, Eduardo Llausas-Magaña, Nidia León-Sicairos, Adrián Canizalez-Roman
Journal: Journal of Infection (2006)
Subsets of Transgenic T Cells That Recognize CD1 Induce or Prevent Murine Lupus: Role of Cytokines
Authors: Defu Zeng, Michael Dick, Lirong Cheng, Masahiko Amano, Sussan Dejbakhsh-Jones, Philip Huie, Richard Sibley, Samuel Strober
Journal: The Journal of Experimental Medicine (1998)

T cells with T cell receptor (TCR) transgenes that recognized CD1 on syngeneic B cells stimulated B cells to secrete immunoglobulins in vitro. The CD4+, CD8+, or CD4−CD8− T cells from the spleen of the TCR transgenic BALB/c donors induced lupus with anti–double stranded DNA antibodies, proteinuria, and immune complex glomerulonephritis in irradiated BALB/c nude mice reconstituted with nude bone marrow. Injection of purified CD4−CD8− T cells from the marrow of transgenic donors prevented the induction of lupus by the transgenic T cells. Transgenic T cells that induced lupus secreted large amounts of interferon (IFN)-γ and little interleukin (IL)-4, and those that prevented lupus secreted large amounts of IL-4 and little IFN-γ or IL-10.
Localised pigmented villonodular synovitis: an uncommon cause of knee pain mimicking a meniscal tear
Authors: R Roach, I dos Remedios
Journal: British Journal of Sports Medicine (2003)

A previously well 30 year old man presented with a short history of intra-articular mechanical locking, swelling, and anteromedial joint line pain. There was localised tenderness, and McMurray’s test was positive. Arthroscopy revealed a 3.6 × 2.6 × 1.5 cm firm pedicular localised pigmented villonodular synovitis originating from the insertion of the anterior horn of the medial meniscus. Owing to its size and consistency, mini-arthrotomy was required. This allowed a return to sporting activities. Localised pigmented villonodular synovitis can mimic symptoms of a meniscal tear.
Renal Toxicogenomic Response to Chronic Uranyl Nitrate Insult in Mice
Authors: Magali Taulan, François Paquet, Christophe Maubert, Olivia Delissen, Jacques Demaille, Marie-Catherine Romey
Journal: Environmental Health Perspectives (2004)

Although the nephrotoxicity of uranium has been established through numerous animal studies, relatively little is known about the effects of long-term environmental uranium exposure. Using a combination of conventional biochemical studies and serial analysis of gene expression (SAGE), we examined the renal responses to uranyl nitrate (UN) chronic exposure. Renal uranium levels were significantly increased 4 months after ingestion of uranium in drinking water. Creatinine levels in serum were slightly but significantly increased compared with those in controls. Although no further significant differences in other parameters were noted, substantial molecular changes were observed in toxicogenomic profiles. UN induced dramatic alterations in expression levels of more than 200 genes, mainly up-regulated, including oxidative-response-related genes, genes encoding for cellular metabolism, ribosomal proteins, signal transduction, and solute transporters. Seven differentially expressed transcripts were confirmed by real-time quantitative polymerase chain reaction. In addition, significantly increased peroxide levels support the implication of oxidative stress in UN toxicant response. This report highlights the potential of SAGE for the discovery of novel toxicant-induced gene expression alterations. Here, we present, for the first time, a comprehensive view of renal molecular events after uranium long-term exposure.
Neurotransmitter depletion compromises the ability of indirect-acting amines to provide inotropic support in the failing human heart.
Authors: J D Port, E M Gilbert, P Larrabee, P Mealey, K Volkman, R Ginsburg, R E Hershberger, J Murray, M R Bristow
Journal: Circulation (1990)

To test the hypothesis that cardiac norepinephrine depletion related to heart failure alters contractile responses to beta-adrenergic agonists with a component of "indirect" action (acting by release of neuronal norepinephrine), we examined the inotropic potential of several pharmacologically distinct beta-agonists. Contractile responses to the nonselective beta-agonist isoproterenol, the beta 2-selective agonist zinterol, and the direct- and indirect-acting agonists dopamine and dopexamine were compared in isolated right ventricular trabeculae removed from failing, nonfailing innervated, and previously transplanted and, therefore, denervated nonfailing human hearts. In failing hearts, the contractile response to isoproterenol was significantly lower (41%) than that in nonfailing innervated hearts. The responses to the mixed agonists dopamine and dopexamine were even more attenuated in failing hearts, to a level 76-90% lower than those of nonfailing innervated hearts. In denervated, previously transplanted, nonfailing hearts, the contractile responses to the mixed agonists dopamine and dopexamine were 66-72% lower than those in the nonfailing innervated group, but the response to isoproterenol was not significantly different. The response to zinterol was not significantly different among the three groups. In subjects with severe heart failure, in vivo hemodynamic responses to dopexamine were compared with those of the direct-acting beta-agonist dobutamine. Responses to dopexamine and dobutamine were measured before and after prolonged continuous infusions of each drug. The response to dopexamine, but not to dobutamine, diminished over time. We conclude that a large component of the inotropic response to dopamine and dopexamine in human hearts is due to the ability of these agonists to promote the release of neuronal norepinephrine; when neuronal norepinephrine is depleted, indirect-acting agonists are less able to produce an inotropic response.
Characteristics of the Relationship between the Flow Rate of Tubular Fluid and Potassium Transport in the Distal Tubule of the Rat
Authors: Robert T. Kunau, Harold L. Webb, Susan C. Borman
Journal: Journal of Clinical Investigation (1974)

The flow rate of tubular fluid has been suggested as one of several factors which may influence potassium transport in the distal convoluted tubule of the kidney. In the present micropuncture studies, the relationship between the flow rate of distal tubular fluid and potassium transport was examined in four groups of rats. Three groups of rats (I, II, and IV) were fed normal rat chow before study whereas one group (III) was fed chow containing 10% KCl. Group II received 10-20 μg/kg per h of d-aldosterone throughout the study. Distal tubular potassium transport in groups I, II, and III was examined before and after an increase in the flow rate of distal tubular fluid as induced by the infusion of an isotonic saline-bicarbonate solution equivalent to 10% of body weight. In group IV, distal tubular potassium transport was examined before and after enhancement of the flow rate by the infusion of hypertonic (15%) mannitol.