A Clinical and Pathological Study of Seventy Cases of Myelofibrosis
Authors: JAMES A. PITCOCK
Journal: Annals of Internal Medicine (1962)

Article1 July 1962A Clinical and Pathological Study of Seventy Cases of MyelofibrosisJAMES A. PITCOCK, M.D., EDWARD H. REINHARD, M.D., F.A.C.P., BERTRAM W. JUSTUS, M.D., ROBERT S. MENDELSOHN, M.D.JAMES A. PITCOCK, M.D., EDWARD H. REINHARD, M.D., F.A.C.P., BERTRAM W. JUSTUS, M.D., ROBERT S. MENDELSOHN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-1-73 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIdiopathic myelofibrosis is commonly described as characterized by splenomegaly, replacement of the bone marrow by fibrous tissue, a leuko-erythroblastic peripheral blood picture, and extramedullary hematopoiesis in the tissues. The relationship of this condition to chronic granulocytic leukemia remains confused because of the existence of cases which appear to be either transitional or intermediate between these 2 conditions. The use of a broad classification, such as myeloproliferative syndrome, serves to point out the similarities of this group of diseases, but the presence of histologically demonstrable fibrous tissue in the bone marrow, whether or not it is of fundamental importance, continues to...References1. WYATTSOMMERS JPSC: Chronic marrow failure, myelosclerosis, and extramedullary hematopoiesis. Blood 5: 329, 1950. CrossrefMedlineGoogle Scholar2. PEACH RJ: Myelonecrosis, extramedullary myelopoiesis, and leukoerythroblastosis. Amer. J. Path. 29: 1029, 1953. MedlineGoogle Scholar3. KNOBLICH R: Extramedullary hematopoiesis presenting as intrathoracic tumors. Cancer 13: 462, 1960. CrossrefGoogle Scholar4. REINHARDNEELYSAMPLES EHCLDM: Radioactive phosphorus in the treatment of chronic leukemias. Ann. Intern. Med. 50: 942, 1959. LinkGoogle Scholar5. KOLER RD: Prognosis in the myelofibrosismyeloid metaplasia syndrome. Clin. Res. Proc. 5: 57, 1957. Google Scholar6. 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Author, Article, and Disclosure InformationAffiliations: St. Louis, MissouriFrom the Department of Pathology and the Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.Requests for reprints should be addressed to James A. Pitcock, M.D., Department of Pathology, Washington University School of Medicine, St. Louis 10, Missouri. 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