The Use of Tetracycline Fluorescence in the Detection of Gastric Malignancy
Authors: L. J. SANDLOW
Journal: Annals of Internal Medicine (1963)

Article1 March 1963The Use of Tetracycline Fluorescence in the Detection of Gastric MalignancyL. J. SANDLOW, M.D., H. A. ALLEN, M.D., H. NECHELES, M.D., PH.D., F.A.C.P.L. J. SANDLOW, M.D.Search for more papers by this author, H. A. ALLEN, M.D.Search for more papers by this author, H. NECHELES, M.D., PH.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-3-409 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe introduction of fluorescent techniques in the study of tissue has provided new approaches for detecting cancer.Rall, Loo, Lane, and Kelly (1) studied a patient with metastatic breast carcinoma who had been treated with a fluorescent riboflavin antagonist, U 6538. At autopsy, a yellow fluorescence in the tumor was noted, which persisted for days, although fluorescence of U 6538 was found to last only for a few hours. Tumors that had fluoresced were studied in other patients who had not received this drug. By a process of elimination it was found that these patients had received tetracycline.The fact...References1. RALLLOOLANEKELLY DPJLMMG: Appearance and persistence of fluorescent material in tumor tissue after tetracycline administration. J. Nat. Cancer Inst. 19: 79, 1957. MedlineGoogle Scholar2. BÖTTIGER LE: On the distribution of tetracycline in the body. Antibiot. Chemother. (NY) 5: 332, 1955. MedlineGoogle Scholar3. MCLEAY JF: Use of systemic tetracyclines and ultraviolet in cancer detection. Amer. J. Surg. 96: 415, 1958. CrossrefMedlineGoogle Scholar4. VASSARSAUNDERSCULLINGS PSAMCF: Tetracycline fluorescence in malignant tumors and benign ulcers. Arch. Path (Chicago) 69: 613, 1960. MedlineGoogle Scholar5. KLINGERKATZ JR: Tetracycline fluorescence in diagnosis of gastric carcinoma. Gastroenterology 41: 29, 1961. CrossrefMedlineGoogle Scholar6. BERKKANTOR JESM: Demethylchlortetracycline induced fluorescence of gastric sediment. JAMA 179: 997, 1962. CrossrefMedlineGoogle Scholar7. RASKINKIRSNERPALMER HFJBWL: Exfoliative cytology of the gastrointestinal tract, in Modern Trends in Gastro-enterology, series 2, edited by Jones, F. A., Paul B. Hoeber, Inc., New York, 1958. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, IllinoisFrom the Departments of Gastrointestinal Research and of Medicine, Michael Reese Hospital and Medical Center, Chicago, Illinois.Supported by a grant from the American Cancer Society, Illinois Division. The Department is supported in part by the Michael Reese Research Foundation.Requests for reprints should be addressed to H. Necheles, M.D., Michael Reese Hospital and Medical Center, 29th Street and Ellis Avenue, Chicago 16, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byStomachPast, Present, and Future of FluorescenceStomachFluorescence of cervical intraepithelial neoplasia induced by tetracycline and acridine orangeEffect of tetracycline on synthesis of collagen and incorporation of 45calcium into bone in foetal and pregnant ratsDegree of fluorescence in the prognosis of malignant tumorsTetracycline fluorescence and cytological procedures compared for the detection of malignancy.Effect of tetracyclines on the turnover of calcium-45 in young ratsA COMPARISON OF TETRACYCLINE FLUORESCENCE AND EXFOLIATIVE CYTOLOGY IN THE DETECTION OF MALIGNANCYGastric Ulcer or Gastric Cancer ?Comparison of tetracycline-induced fluorescence test and exfoliative cytology of gastric contentTetracycline Fluorescence of Pathologic Pulmonary TissuesTetracycline ultraviolet fluorescence in bladder carcinomaAn Evaluation of the Tetracycline-fluorescence Test in the Diagnosis of Gastric Cancer Comparison with CytologyALVIN J. CUMMINS, M.D., F.A.C.P., MICHAEL L. GOMPERTZ, M.D., F.A.C.P., JOHN H. KIER, M.D. 1 March 1963Volume 58, Issue 3Page: 409-413KeywordsAutopsyBreast cancerCell biologyDrugsHospital medicineRiboflavinTetracyclines Issue Published: 1 March 1963 PDF downloadLoading ...