SILAGE GAS POISONING: NITROGEN DIOXIDE PNEUMONIA, A NEW DISEASE IN AGRICULTURAL WORKERS
Authors: R. R. GRAYSON
Journal: Annals of Internal Medicine (1956)

Article1 September 1956SILAGE GAS POISONING: NITROGEN DIOXIDE PNEUMONIA, A NEW DISEASE IN AGRICULTURAL WORKERSR. R. GRAYSON, M.D.R. R. GRAYSON, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-3-393 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwo cases of acute respiratory disease due to inhalation of silage gas were encountered in August, 1954. One was fatal. A thorough investigation of these two cases and of the silage gas that caused the illness indicates that the disease was caused by the oxides of nitrogen.A careful review of the literature indicates that, although chemical pneumonia and fatalities due to fumes of the oxides of nitrogen have been described many times in industry, they apparently have not been reported in cases of silage gas poisoning. The following two cases, therefore, are believed to be the first cases reported...Bibliography1. Personal communication from J. H. Longwell, Director, University of Missouri, Division of Agricultural Sciences, Columbia, Missouri, July 8, 1955. Google Scholar2. : Official methods of analysis of the Association of Official Agricultural Chemists, 7th Ed. 1950, page 204. Google Scholar3. Saltzman BE: Colorimetric microdetermination of nitrogen dioxide in the atmosphere, Analytical Chemistry 26: 1949-1955, 1954. CrossrefGoogle Scholar4. PfanderMuhrer WHME: Forage poisoning in Missouri due to excessive amounts of nitrate, Missouri Agricultural Experiment Station Bulletin 652, pp. 19-20, April 1, 1955. Google Scholar5. South Dakota Experiment Station Bulletin 424, Nitrate poisoning, 1952. Google Scholar6. PriceRoetheBradshaw DJHEMA: Prevention of silo gas accidents, Agricultural Engineering 18: 104-106 (Mar.) 1937. Google Scholar7. PetersonThomaAnderson WHRWRF: Yellow gas from corn silage, Hoard's Dairyman, December, 1949, pp. 870-871. Google Scholar8. Fostvedt GA: Silage gas poisoning, Wisconsin M. J. 50: 1103-1104 (Nov.) 1951. MedlineGoogle Scholar9. Yellow silo gas is nitrogen dioxide, University of Wisconsin Bulletin 496, pp. 87-89, 1952. Google Scholar10. Schroeppel JE: Death in a silo, J. A. M. A. 153: 893 (Oct. 31) 1953. Google Scholar11. Charleroy DK: Nitrous and nitric gas casualties, U. S. Nav. M. Bull. 44: 435-437 (Feb.) 1945. Google Scholar12. McAdamsKrop AJS: Injury and death from red fuming nitric acid, J. A. M. A. 158: 1022-1024 (July 23) 1955. CrossrefMedlineGoogle Scholar13. Flury F: Die Rolle des Stickstoffmonoxyds bei der Vergiftung durch Nitrose Gase, Arch. f. exper. Path. u. Pharmakol. 157: 104, 1930, quoted by McAdams.12 CrossrefGoogle Scholar14. Adley FE: Exposures to oxides of nitrogen accompanying shrinking operations, J. Indust. Hyg. and Toxicol. 28: 17-20, 1946. MedlineGoogle Scholar15. Rossano AT: A fatal case of poisoning by oxides of nitrogen, J. Indust. Hyg. and Toxicol. 27: 207-208, 1945. Google Scholar16. Feil A: Notes de medecine pratique hygiene et medecine du travail, Presse méd. 59: 1688 (Dec.) 1951. MedlineGoogle Scholar17. McConnellFlinnBrandt WJRHAD: Occupational diseases in government-owned ordnance explosive plants, Occup. Med. 1: 551-618, 1946. MedlineGoogle Scholar18. Fabian FW: Dangers from poisonous gases in silo filling, Michigan Agricultural Experiment Station Quarterly Bulletin No. 9, page 23, August 23, 1926. Google Scholar19. Silos: Types and Construction, Farmers' Bulletin No. 1820, U. S. Department of Agriculture: Warning—gas danger in silos, May 1939, Revised September 1948, Cover. Google Scholar20. Personal communication: Excerpt from letter on nitrate poisoning (University of Missouri), A. G. Hogan, June 8, 1955. Google Scholar21. Deadly gases sometimes accumulate in silos, Agricultural Gaz. New South Wales 50: 371 (July 1) 1939. Google Scholar22. LeRossignol WJ: Irritants and gases affecting workers in silo, J. A. M. A. 98: 2307 (June 25) 1932. Google Scholar23. Fairhall LT: Nitrogen oxides, in Industrial toxicology, 1949, The Williams and Wilkins Co., Baltimore, pp. 116-120. Google Scholar24. LowrySchuman TLM: Personal communication, to be published. (U. of Minn. Med. School.) Google Scholar25. DelaneySchmidtStroebel LTHWCF: Silo-filler's disease, Proc. Staff Meet., Mayo Clin. 31: 189-198 (Apr. 4) 1956. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: R. R. GRAYSON, M.D.Affiliations: Perryville, Missouri*Received for publication March 21, 1956.Requests for reprints should be addressed to R. R. Grayson, M.D., Medical Arts Building, Perryville, Missouri. 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