tbuckley/cabot-search huggingface dataset:
SANITARY ADMINISTRATION.Read in the Section on State Medicine, at the Forty-fourth Annual Meeting of the American Medical Association.
Authors: C. A. LINDSLEY
Journal: JAMA (1893)

The value of health to the family, to the community and to the nation has come to be understood and appreciated as it never was before. During the last few decades public sanitation has made surprising progress. The positive discoveries relating to the protection and preservation of health have proved their verity by their practical application, and have strengthened the claim of public hygiene to be ranked among the applied sciences. In scarcely any department of human progress have the indications of successful accomplishment been more marked, more satisfactory, or of greater direct value to the welfare and happiness of mankind, than in the unfolding and development of the principles and natural laws upon which modern scientific public hygiene is based. Let us take a retrospective glance at the beginning of a movement which is still progressing with an undiminished impetus. In the East End of London, known as Whitechapel,
Current Therapy of Malignant Lymphomas.
Authors: G. Lennard Gold
Journal: Annals of Internal Medicine (1965)

s1 May 1965Current Therapy of Malignant Lymphomas.G. Lennard Gold, M.D., F.A.C.P., Bruce I. Shnider, M.D., F.A.C.P., John J. Lynch, M.D.G. Lennard Gold, M.D., F.A.C.P., Bruce I. Shnider, M.D., F.A.C.P., John J. Lynch, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1092_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the early 1940's mechlorethamine, nitrogen mustard (HN2), became available for the treatment of human malignant disease. It was soon apparent that this agent was able to produce objective responses in patients with lymphomatous disease. After this advance in cancer chemotherapy, a variety of alkylating agents and other chemicals have become available for the treatment of malignant lymphomas.In addition to the alkylating agents a new group of plant alkaloids are now available for the treatment of these diseases. Adrenal steroids may be helpful in the primary therapy of these diseases as well as helping to alleviate the hemologic disorders... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1092-1093KeywordsAlkaloidsCancer chemotherapyCancer treatmentLymphomaMechlorethamineSteroids Issue Published: 1 May 1965 PDF downloadLoading ...
NIH Panel: Name Change, New Priorities Advised for Polycystic Ovary Syndrome
Authors: Tracy Hampton
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vascular calcification: Contribution of parathyroid hormone in renal failure
Authors: K.-R. Neves, F.-G. Graciolli, L.-M. dos Reis, R.-G. Graciolli, C.-L. Neves, A.-O. Magalhães, M.-R. Custódio, D.-G. Batista, V. Jorgetti, R.M.A. Moysés
Journal: Kidney International (2007)
Histochemical study of the effect of enzyme inhibitors on gastric secretion.
Authors: G L Stoffels, W Gepts, J J Desneux
Journal: Gut (1966)

EDITORIAL COMMENT Inhibitors of sulphydryl enzymes are known to block gastric acid secretion.The effect of three such inhibitors on particular enzymes in the gastric mucosa, as demonstrated by histochemical methods, is described in this paper in an attempt to explain the mechanism by which acid secretion is blocked.Further work will be needed to decide whether these inhibitors act by blocking energy-producing systems or by inhibiting a specific enzyme system involved in the produc- tion of hydrogen ion.
Morbidity from Acute Carbon Monoxide Poisoning at Three-year Follow-up
Authors: J. S. Smith, S. Brandon
Journal: BMJ (1973)

Seventy-four survivors of acute carbon monoxide poisoning were followed up for an average of three years. In eight patients gross neuropsychiatric damage was directly attributable to the poisoning. Three patients had committed suicide and eight had died from other causes. Morbidity and mortality in those deliberately and accidentally poisoned was approximately equal. Of 63 patients alive at follow-up eight showed an improvement and 21 (33.3%) a deterioration of personality after poisoning, and 27 (43%) reported a subsequent impairment of memory. Deterioration of personality and memory impairment were highly correlated. The level of consciousness on admission to hospital in the acute phase of poisoning correlated significantly with the development of gross neuropsychiatric sequelae. These findings emphasize the importance of prompt and efficient treatment of carbon monoxide poisoning and the need to follow-up all cases in the anticipation of a relapsing course or the development of sequelae.
Reviewing Goodman and Gilman's
Authors: BERNHARD R. WINKELMANN
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 June 1986Reviewing Goodman and Gilman'sBERNHARD R. WINKELMANN, M.D.BERNHARD R. WINKELMANN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-6-897_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the review of the seventh edition of Goodman and Gilman's The Pharmacological Basis of Therapeutics, I miss more critical comments by the reviewer (1). I bought the new edition so that I would have the "standard textbook" in (clinical) pharmacology, just as Mandell and colleagues' textbook of infectious disease (2) is the "gold standard" for that field. The new edition of Goodman and Gilman's, although relying on a great tradition, is far from being such a standard in is field.This new edition has strong points, but it also has its weaknesses. For a 1985 publication...References1. AZARNOFF D. Goodman and Gilman's The Pharmacological Basis of Therapeutics [Book Review]. Ann Intern Med. 1986; 104:453. LinkGoogle Scholar2. MANDELLDOUGLASBENNETT GRJ, eds. Principles and Practice of Infectious Diseases. 2nd ed. New York: John Wiley & Sons; 1985. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Elisabeth Klinik 6630 Saarlouis, West Germany PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOmissions from A Library for InternistsPERRY J. RUSH, M.D. 1 June 1986Volume 104, Issue 6Page: 897-897KeywordsClinical pharmacologyDrug therapyInfectious diseases ePublished: 1 December 2008 Issue Published: 1 June 1986 PDF downloadLoading ...
Cardiomyocytes from human stem cells restore heart rhythm
Authors: Judy Siegel-Itzkovich
Journal: BMJ (2004)

Cardiomyocytes developed from human embryonic stem cells can act as biological pacemakers and restore myocardial mechanical function when transplanted into animal hearts with a slow heart rate, according to research published last week.

Researchers from the Technion-Israel Institute of Technology in Haifa, Israel, generated cardiomyocyte cell grafts from human embryonic cells in vitro. They showed that the cells formed structural and electromechanical connections with cultured rat cardiomyocytes. However, to be …
Protomusic and protolanguage as alternatives to protosign
Authors: W. Tecumseh Fitch
Journal: Behavioral and Brain Sciences (2005)

Explaining the transition from a signed to a spoken protolanguage is a major problem for all gestural theories. I suggest that Arbib's improved “beyond the mirror” hypothesis still leaves this core problem unsolved, and that Darwin's model of musical protolanguage provides a more compelling solution. Second, although I support Arbib's analytic theory of language origin, his claim that this transition is purely cultural seems unlikely, given its early, robust development in children.
INFARCT TISSUE HETEROGENEITY BY CONTRAST-ENHANCED MRI IS A NOVEL PREDICTOR OF MORTALITY IN PATIENTS WITH CHRONIC CORONARY ARTERY DISEASE AND LEFT VENTRICULAR DYSFUNCTION
Authors: Siddique Abbasi, Eri Watanabe, Ravi Shah, Bobby Heydari, Tomas Neilan, Otavio Coelho-Filho, Jiazuo Feng, Mike Steigner, Ron Blankstein, Michael Jerosch-Herold, Raymond Kwong
Journal: Journal of the American College of Cardiology (2013)
Rise in chronic defibrillation thresholds in nonthoracotomy implantable defibrillator.
Authors: F J Venditti, D T Martin, G Vassolas, S Bowen
Journal: Circulation (1994)

BACKGROUND To establish the chronic stability of defibrillation thresholds (DFTs) in a transvenous cardioverter/defibrillator (TCD) system, we studied 37 consecutive patients with TCD systems implanted for &gt; 6 months. METHODS AND RESULTS DFT was measured by a step-down method at implant and 2 and 6 months later. The mean ejection fraction was 34.5 +/- 14.3%. Coronary artery disease with previous myocardial infarction was present in 31 patients. The mean DFT rose from 13.3 +/- 4.3 J at implant to 16.5 +/- 4.7 J at 2 months (P &lt; .001) and 17.6 +/- 5.4 J at 6 months (P &lt; .0001). ANOVA revealed a statistically significant rise in DFT over time (P &lt; .0005). At 2 months, 25 patients had a rise in DFT, and 14 had a rise &gt; or = 5 J. The observed rise at 2 months persisted in 19 patients. A chronic rise, defined as &gt; or = 5 J rise at 6 months, occurred in 17 patients. Univariate analysis of clinical as well as implant variables revealed no predictors of a rise in DFT in this group. CONCLUSIONS We conclude that there is a significant rise in DFT at 2 and 6 months in this TCD system. Although the chronic threshold remained well within the available energy range of the pulse generator, this observation has important implications for implantation guidelines, programming, and future pulse generator development for TCD patients.
The Psychiatric Interview in Clinical Practice
Authors: Wallace C. Ellerbroek
Journal: JAMA (1972)

The authors have used a refreshing approach to the teaching of interview technique by serially presenting the primary categories of psychiatric patients, and outlining for each the psychopathology, thepsychodynamics, and the specific problems arising during the interview of that type of patient. The orientation is psychoanalytic, but the authors are sufficiently flexible to be comfortably eclectic in situations which require other modes. The student of psychotherapy will find real assistance in the sections on the management of the interview and the specific techniques of establishing the therapeutic alliance. Special situations are dealt with in a second section on the psychosomatic patient, the ward consultation, the psychologically unsophisticated patient, and the psychiatric emergency. The concluding section gives advice on the problems of the telephone in psychiatric practice, the interview via an interpreter, and note-taking. Very few questions are begged, and the majority of the queries a beginning therapist might have are answered; exceptions
Diabetes in Asian Immigrant Populations—Reply
Authors: Juliana C. N. Chan
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Megakaryocytes promote hepatoepithelial liver cell development in E11.5 mouse embryos by cell-to-cell contact and by vascular endothelial growth factor A signaling
Authors: Natalia Serrano, Isabel Cortegano, Carolina Ruiz, Mario Alía, Belén de Andrés, María Teresa Rejas, Miguel A.R. Marcos, María Luisa Gaspar
Journal: Hepatology (2012)

In the mouse embryo, hematopoietic progenitor cells migrate to the fetal liver (FL) between gestational days (E) 9.5 and 10.5, where they rapidly expand to form the main fetal reservoir of hematopoietic cells. The embryonic megakaryocyte progenitors (MKPs) in the E11.5 FL were identified as CD49fHCD41H (and c-KitDKDR+CD42+CD9++CD31+) cells, expressing several hepato-specific proteins. Unlike adult bone marrow megakaryocytes (MKs), embryonic MKPs were CD45− and represent an abundant population in the FL. The CD49fHCD41H MKPs purified by cytometry differentiated in vitro to produce proplatelets, independent of thrombopoietin stimulation, and they responded to stimulation with adenosine diphosphate, thrombin, and the PAR4 thrombin receptor-activating peptide. Moreover, after removing CD49fHCD41H MKPs from purified E11.5 FL hepatoepithelial-enriched cell preparations (c-KitDCD45−Ter119−), the remaining CD49fD cells neither differentiated nor survived in vitro. Indeed, direct cell-to-cell contact between the CD49fHCD41H and CD49fD populations was required to promote the hepatocyte differentiation of CD49fD cells. The addition of vascular endothelial growth factor A (VEGF-A) and medium conditioned by E11.5 CD49fHCD41H MKPs produced a partial effect on CD49fD cells, inducing the formation of hepatoepithelial layers. This effect was abolished by anti-VEGF-A antibodies. Together, these findings strongly suggest that CD49fHCD41H MKPs are fundamental to promote FL development, as proposed in adult liver regeneration. Conclusion: The cells of the MK lineage present in the developing mouse embryo liver promote the growth of hepatoepithelial cells in vitro through VEGF-A signaling and may play a role in liver development in vivo. (HEPATOLOGY 2012;56:1934–1945)
Health Care Is Different—That's Why Expenditures Matter
Authors: Victor R. Fuchs
Journal: JAMA (2010)

HEALTH CARE EXPENDITURES IN THE UNITED STATES have been increasing much more rapidly than the rest of the economy over the past 30 years. The average gap, 2.8% per annum, results in health care’s share of the economy doubling every 26 years. Why does this matter? Would it matter if expenditures for personal computers were increasing 2.8% per annum more rapidly than the rest of the economy? The appropriate response would be, “So what?” Concern about health care expenditures is often attributed to the large role of these expenditures in the federal budget and the effect on the deficit. But that is not the whole story. A dollar spent on health care is not a priori more fiscally toxic than a dollar spent on transportation or education or any other item in the government budget. Moreover, health expenditures in the private sector have also been increasing rapidly. What matters most are the characteristics that distinguish health care from other goods and services: great uncertainty about an individual’s need for care, the essential nature of some care, and the ambiguous role of competition. These characteristics help explain the distinctive institutional features of health care and their consequences.
Abstract 3546: Transcriptional activation of Thioredoxin interacting protein by small activating RNA exerts cell growth inhibition in A549 human lung cancer cells
Authors: Ki Hwan Park, Moo-Rim Kang, Sang-Bae Han, Jieun Yun, Chang Woo Lee, Soo Jin Oh, Youngsoo Kim, Jong Soon Kang
Journal: Cancer Research (2014)

Abstract TXNIP (also known as VDUP1 or TBP-2) has been identified as a tumor suppressor gene (TSG) and downregulated in various solid tumors and hematological malignancies. In recent years, a therapeutic application of small activating RNA for cancer treatment has been suggested. Therefore, we designed small activating RNA targeting TXNIP promoter (hsaTXNIP-834) and investigated the effect of hsaTXNIP-834 on cell growth inhibition in A549 human lung carcinoma. Transfection of hsaTXNIP-834 induced transcriptional activation of TXNIP gene and protein expression in a dose dependent manner in A549 cells. Transfection of hsaTXNIP-834 also stimulated demethylation of CpG island region of TXNIP gene promoter. In addition, hsaTXNIP-834 leaded to cell growth inhibition in a dose dependent manner. Further study demonstrated that hsaTXNIP-834 induces G0/G1 and G2/M phase cell cycle arrest. Moreover, hsaTXNIP-834 induced p53 expression and reduced phosphorylation of RB protein. However, co-transfection of TXNIP or Ago2 siRNA reversed cell growth inhibition by hsaTXNIP-834. Collectively, our results suggest that hsaTXNIP-834 inhibits the growth of A549 lung carcinoma cells by inducing G0/G1 and G2/M phase cell cycle arrest and this is mediated, at least in part, by transcriptional activation of TXNIP by hsaTXNIP-834. Citation Format: Ki Hwan Park, Moo-Rim Kang, Sang-Bae Han, Jieun Yun, Chang Woo Lee, Soo Jin Oh, Youngsoo Kim, Jong Soon Kang. Transcriptional activation of Thioredoxin interacting protein by small activating RNA exerts cell growth inhibition in A549 human lung cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3546. doi:10.1158/1538-7445.AM2014-3546
A Crusade against Acute Rheumatism
Authors: W. T. Ritchie
Journal: BMJ (1936)

Rheumatism may be defined as a disease probably in- fective, at times acute, at others latent, quiescent, sub- acute, or chronic, of which the chief manifestations are carditis and chorea in children of school age, acute polyarthritis and carditis in adolescents and young adults, and subacute and chronic inflammatory heart disease, fibrositis, and chronic arthritis in later adult life.The term " acute rheumatism" is not synonymous with, and is not restricted to, rheumatic fever, but includes other acute manifestations such as chorea and carditis.Rheu- matic fever in itself is seldom a cause of death.In England and Wales during 1933 the crude death rate from this disease was thirty-two per million living: in Scotland during the same year only 171 deaths were registered as due to rheumatic fever. Acute' Rheumatic CarditisAcute rheumatic carditis is a frequent but not inevit- able manifestation of acute rheumatism.It occurred in 46 per cent. of 244 -cases of 'acute rheumatism coming under my observation"; acute pericarditis, the least serious form of rheumatic heart disease, developed in 14 per cent., acute endocarditis in 44 per cent.The immediate prognosis in acute and subacute rheu- matic carditis is usually favourable.The illness may be protracted for months,fever and arthritis may 'recur, and the aortic as well as the mitral valve may become incompetent.Nevertheless the patient may be expected to recover from'the acute illness.' Virulent cases simula- ting subacute bacterial endocarditis, running 'a speedily fatal course,' and developing in 'some instances a' terminal haemorrhagic eruption, -are rare.Only' thirteen of the 244 cases-that is, 5 per cent.-of my series-ultimately developed a terminal streptococcal endocarditis.In many patients who are apparently making a satisfactory recovery from uncomplicated rheumatic fever a latent carditis is slowly developing, and may not be detected' until months or years later.Moreover, rheumatic carditis developing insidiously and slowly in childhood or adolescence may be a complication atid sequel of an apparently trivial rheumatic illness, such as " growing pains " or a mild febrile disorder which was thought to be influenza.Rheumatism often sails, under an influenzal flag. Chronic Mitral DiseaseIf the patient survives the acute stage he gradually passes into the third phase of the disease, that of chronic mitral stenosis and incompetence without myocardial * Portion of an address given to the Forfarshire Medical Associa- tion in November, 1935.
Correlates of T-cell–mediated viral control and phenotype of CD8+ T cells in HIV-2, a naturally contained human retroviral infection
Authors: Thushan I. de Silva, Yanchun Peng, Aleksandra Leligdowicz, Irfan Zaidi, Lucy Li, Harry Griffin, Marie-Eve Blais, Tim Vincent, Mavinga Saraiva, Louis-Marie Yindom, Carla van Tienen, Philippa Easterbrook, Assan Jaye, Hilton Whittle, Tao Dong, Sarah L. Rowland-Jones
Journal: Blood (2013)
Comparative Effectiveness — Thinking beyond Medication A versus Medication B
Authors: Kevin G. Volpp, Anup Das
Journal: New England Journal of Medicine (2009)

The American Recovery and Reinvestment Act of 2009 (ARRA), the stimulus package signed into law by President Barack Obama on February 17, 2009, directs $1.1 billion to support "the development and dissemination of research assessing the comparative effectiveness of health care treatments and strategies, including through efforts that . . . conduct, support, or synthesize research that compares the clinical outcomes, effectiveness, and appropriateness of items, services, and procedures that are used to prevent, diagnose, or treat diseases, disorders, and other health conditions."The rationale for seeking better information on comparative effectiveness is well understood. Many existing devices and therapeutic approaches have . . .