Disodium Cromoglycate in Bronchial Asthma
Authors: HYMAN CHAI
Journal: Annals of Internal Medicine (1969)

Editorials1 December 1969Disodium Cromoglycate in Bronchial AsthmaHYMAN CHAI, M.D., LEIZER MOLK, M.D., ELLIOTT MIDDLETON JR., M.D.HYMAN CHAI, M.D.Search for more papers by this author, LEIZER MOLK, M.D.Search for more papers by this author, ELLIOTT MIDDLETON JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-6-1212 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe appearance of any new drug for the control of bronchial asthma excites both physician and patient alike, for even the most modern management of severe asthma still leaves much to be desired. A new possibility for improved pharmacologic control is the compound disodium cromoglycate (DSC, FPL670, "Intal"). Disodium cromoglycate is a member of the "chromone" class of compounds and is a chemical relative of khellin, a plant-derived substance known to have bronchodilator properties (1, 2).Of a number of compounds in the chromone series, DSC was found to be the most active in protecting against experimentally induced asthma (3),...References1. ANREPBARSOUMMISRAHY GVGSG: Ammi visnaga in the treatment of the anginal syndrome. Brit. Heart J. 8: 171, 1946. CrossrefGoogle Scholar2. ANREPBARSOUMMISRAHY GVGSG: Therapeutic uses of khellin. Lancet 1: 557, 1947. CrossrefMedlineGoogle Scholar3. ALTOUNYAN RE: Inhibition of experimental asthma by new compound—disodium cromoglycate "Intal." Acta Aller. (Kobenhaven) 22: 485, 1968. Google Scholar4. SHEARDKILLINGBACKBLAIR PPGAM: Antigen induced release of histamine and SRS-A from human lung passively sensitized with reaginic serum. Nature (London) 216: 283, 1967. CrossrefMedlineGoogle Scholar5. COX JS: Disodium cromoglycate (FPL 670) ("Intal"): a specific inhibitor of reaginic antibody-antigen mechanisms. Ibid., p. 216. Google Scholar6. ORANGEAUSTEN RPKF: Pharmacologic dissociation of immunologic release of histamine and slow reacting substance of anaphylaxis in rats. Proc. Soc. Exp. Biol. Med. 129: 836, 1968. CrossrefMedlineGoogle Scholar7. HOWELLALTOUNYAN JBRE: A double-blind trial of disodium cromoglycate in the treatment of allergic bronchial asthma. Lancet 2: 539, 1967. CrossrefMedlineGoogle Scholar8. GRANTCHANNELLDREYER IWSJC: Disodium cromoglycate in asthma. Ibid., p. 673. Google Scholar9. HOWELLALTOUNYAN JBRE: Disodium cromoglycate in asthma. Ibid., p. 777. Google Scholar10. MORRISON-SMITHDEVEY JGF: A clinical trial of disodium cromoglycate ("Intal") in the treatment of asthma in children. Brit. Med. J. 2: 340, 1969. CrossrefGoogle Scholar11. LOPEZFRANKLINLOWELL MWFC: A "double-blind" study of disodium cromoglycate in bronchial asthma. J. Allerg. 41: 89, 1968. Google Scholar12. CHENMOORENORMANVAN METRE JLNKPSTE: Disodium cromoglycate, a new compound for the prevention of exacerbations of asthma. J. Allerg. 43: 89, 1969. CrossrefMedlineGoogle Scholar13. PEPYSHARGREAVECHAN JFEM: Inhibitory effects of disodium cromoglycate on allergen-inhalation tests. Lancet 2: 134, 1968. CrossrefMedlineGoogle Scholar14. MORANBANKIERBOYD FJDG: Disodium cromoglycate in the treatment of allergic bronchial asthma. Ibid., p. 137. Google Scholar15. KENNEDY MC: Disodium cromoglycate in the control of asthma. Brit. J. Dis. Chest 63: 96, 1969. CrossrefMedlineGoogle Scholar16. KIDNERMEISNERPRIDEPEARSON PHPNBRS: Disodium cromoglycate in the treatment of bronchial asthma. Lancet 2: 655, 1968. CrossrefMedlineGoogle Scholar17. HERXHEIMERBEWERSDORFF HH: Disodium cromoglycate in the prevention of induced asthma. Brit. Med. J. 2: 220, 1969. CrossrefMedlineGoogle Scholar18. FARNHAMLOWELLFRANKLIN JEFCW: A clinical trial of disodium cromoglycate. J. Allerg. 43: 156, 1969. Google Scholar19. CHAIPURCELLBRADYFALLIERS HKKCJ: Therapeutic and investigational evaluation of asthmatic children. J. Allerg. 41: 23, 1968. CrossrefMedlineGoogle Scholar20. GREGGBOTTEN IJ: Sudden death in a young asthmatic. Brit. Med. J. 2: 29, 1969. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HYMAN CHAI, M.D.; LEIZER MOLK, M.D.; ELLIOTT MIDDLETONJR., M.D.Affiliations: Children's Asthma Research Institute and Hospital Denver, Colo. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA Double-Blind Comparative Study of Pelletized Cromolyn versus Cromolyn Blend in the Treatment of AsthmaA Clinical Index of Disability Due to Chronic Asthma Tested During a Trial of Cromolyn Sodium TreatmentBronchial Asthma Treated with Cromolyn Sodium: A Double-Blind Crossover StudyA Perspective on the Role of Cromolyn Sodium as an Antiasthmatic Agent 1 December 1969Volume 71, Issue 6Page: 1212-1214KeywordsAsthmaBronchodilatorsDrug regulationDrugs ePublished: 1 December 2008 Issue Published: 1 December 1969 PDF downloadLoading ...