Aerosolized Pentamidine and Pneumocystis carinii Pneumonia
Authors: A. Bruce Montgomery, David W. Feigal, John M. Luce, Philip C. Hopewell, Daniel F. Hoth, Maureen W. Myers, Judith E. Feinberg, John Mills, Fred R. Sattler
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 April 1989Aerosolized Pentamidine and Pneumocystis carinii PneumoniaA. Bruce Montgomery, MD, David W. Feigal, MD, John M. Luce, MD, Philip C. Hopewell, MD, Daniel F. Hoth, MD, Maureen W. Myers, PhD, Judith E. Feinberg, MD, John Mills, MD, Fred R. Sattler, MDA. Bruce Montgomery, MDSearch for more papers by this author, David W. Feigal, MDSearch for more papers by this author, John M. Luce, MDSearch for more papers by this author, Philip C. Hopewell, MDSearch for more papers by this author, Daniel F. Hoth, MDSearch for more papers by this author, Maureen W. Myers, PhDSearch for more papers by this author, Judith E. Feinberg, MDSearch for more papers by this author, John Mills, MDSearch for more papers by this author, Fred R. Sattler, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-8-669_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:In a recent editorial Armstrong and Bernard (1) stated that "aerosol pentamidine should not be used for treatment ofPneumocystis cariniipneumonia" because of excess risk of treatment failure, disseminated pneumocystosis, pulmonary hemorrhage, and death with this form of therapy. These conclusions are not supported by data available to the authors at the time the editorial was written. The work of Godfrey-Faussett, Miller and Semple (Nebulized pentamidine [Letter].Lancet. 1988;1:645-6) cited by Armstrong and Bernard to support their editorial has been repeated with a different aerosol delivery system (2). With the Respirgard II jet nebulizer being used...References1. ArmstrongBernard DE. Aerosol pentamidine. Ann Intern Med. 1988;109:852-4. LinkGoogle Scholar2. MillerSemple RS. Pneumocystis carinii pneumonia treated with nebulized pentamidine using a respirgard II nebulizer. Thorax. 1989;[in press]. CrossrefGoogle Scholar3. MontgomeryDebsLuce ARJ. Aerosolized pentamidine as sole therapy for Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome. Lancet. 1987;2:480-3. CrossrefMedlineGoogle Scholar4. MontgomeryDebsLuce ARJ. Selective delivery of pentamidine to the lung by aerosol. Am Rev Respir Dis. 1988;137:477-88. CrossrefMedlineGoogle Scholar5. O'DohertyThomasPage MSC. Differences in relative efficiency of nebulisers for pentamidine administration. Lancet. 1988;2:1283-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: A. Bruce Montgomery, MD; David W. Feigal, MD; John M. Luce, MD; Philip C. Hopewell, MD; Daniel F. Hoth, MD; Maureen W. Myers, PhD; Judith E. Feinberg, MD; John Mills, MD; Fred R. Sattler, MDAffiliations: National Institute of Allergy Infectious Diseases Bethesda, MD 20892 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPneumocystis cariniiTraitement de relais de la pneumopathie à Pneumocystis carinii par les aérosols de pentamidineAerosol Pentamidine-induced BronchoconstrictionAntiprotozoal drugsExtrapulmonary Pneumocystis InfectionMario C. Raviglione, MD, Peter Mariuz, MD, Jeffrey Sugar, MD, Michael P. Mullen, MD 15 April 1989Volume 110, Issue 8Page: 669-669KeywordsHemorrhagePneumocystis carinii pneumonia ePublished: 1 December 2008 Issue Published: 15 April 1989 PDF downloadLoading ...