tbuckley/cabot-search huggingface dataset:
The Quality of Quality-of-Life Measurements-Reply
Authors: Alvan R. Feinstein
Journal: JAMA (1995)

<h3>In Reply.</h3> —We thank the writers of these letters for contributing to a long overdue discussion about how to evaluate a patient's quality of life. We especially applaud Dr Hürny and colleagues for using global ratings to measure important clinical phenomena. These ratings, which can capture the disparate values and preferences of individual patients, offer investigators the most overtly sensible approach to measure quality of life. We acknowledge that an instrument may not be clinically useful, despite high face validity, if it cannot measure the desired phenomenon consistently and accurately. We remind Drs Perneger and Hudelson, however, that face validity is often the most important attribute of an instrument that is intended to reflect the complex observations of clinical experience. If aimed at the wrong thing or constructed in an unsatisfactory way, the instrument will lack clinical sensibility and will be inadequate no matter how many statistical accolades are acquired
Multicomponent Fibers by Multi‐interfacial Polyelectrolyte Complexation
Authors: Andrew C. A. Wan, Meng Fatt Leong, Jerry K. C. Toh, Yuangang Zheng, Jackie Y. Ying
Journal: Advanced Healthcare Materials (2011)

In multi-interfacial polyelectrolyte complexation (MIPC), fusion of nascent fibers from multiple interfaces brings the interfaces to a point from which a composite fiber is drawn. MIPC applied to two, three, and four polyelectrolyte complex interfaces leads to various patterned multicomponent fibers. Cells encapsulated in these fibers exhibit migration, aggregation and spreading in relation to the initial cell or matrix pattern.
Binding of Drugs to Serum Albumin
Authors: Jan Koch-Weser, Edward M. Sellers
Journal: New England Journal of Medicine (1976)

Most drugs are carried from their sites of absorption to their sites of action and elimination by the circulating blood. Some drugs are simply dissolved in serum water, but many others are partly associated with blood constituents such as albumin, globulins, lipoproteins and erythrocytes. For the great majority of drugs binding to serum albumin is quantitatively by far the most important and often accounts for almost the entire drug binding in plasma.1 2 3 Albumin binding influences the fate of drugs in the body. Only the unbound or free drug diffuses through capillary walls, reaches the site of drug action, and is . . .
Eyes, amygdala, and other models of face processing: Questions for the SIMS model
Authors: Bhismadev Chakrabarti
Journal: Behavioral and Brain Sciences (2010)

Abstract This commentary raises general questions about the parsimony and generalizability of the SIMS model, before interrogating the specific roles that the amygdala and eye contact play in it. Additionally, this situates the SIMS model alongside another model of facial expression processing, with a view to incorporating individual differences in emotion perception.
Localization of Tc-99m Sestamibi and TI-201 in an Unsuspected Calcified Intrathoracic Mass
Authors: P KANDULA, P SHIRAZI
Journal: Clinical Nuclear Medicine (1995)

Tc-99m MIBI and TI-201 uptake have been reported in benign and malignant lesions. However, concordant uptake of both radiotracers has been described infrequently. The authors report a patient with a case history of tuberculosis and breast cancer who underwent a TI- 201 cardiac stress–planar study initially for complaints of angina pectoris, and 3 years later a follow-up Tc-99m MIBI cardiac study was completed for similar complaints. These studies incidentally revealed uptake of TI-201 and Tc-99m MIBI in a large left lung mass unchanged in size between the two studies. CT with intravenous contrast performed 2 months after the Tc-99m MIBI study revealed a 9 cm calcified soft-tissue mass in the left lung with adjacent pleural calcifications.
Human Cardiac Troponin T: Cloning and Expression of New Isoforms in the Normal and Failing Heart
Authors: Laurence Mesnard, Damien Logeart, Sylvie Taviaux, Sylvie Diriong, Jean-Jacques Mercadier, Françoise Samson
Journal: Circulation Research (1995)

Abstract Troponin T, like many myofibrillar proteins, exists as multiple isoforms encoded by distinct genes or generated by splicing of the same primary RNA transcript. We have previously cloned the first human cardiac troponin T (cTnT) cDNA and showed the differential expression of cTnT in cardiac and skeletal muscle during ontogenic development. In this work we located the human cTnT gene by means of fluorescent in situ hybridization to 1q32 and, by sequencing thirteen cDNAs isolated from a human fetal heart cDNA library, identified three new isoforms resulting from specific combinations of three variable regions in human cTnT cDNA. The first variable region is a 30-bp box located at the 5′ end of the cDNA, which can be excised either totally or only from the first 3 bp onwards; the second is a codon which can be completely excised; and the third is a 9-bp box in the 3′ half of the cDNA, which can also be excised either totally or only from the first 3 bp. The existence of the corresponding RNAs in fetal and adult ventricles was confirmed by RNase protection studies. No accumulation of the fetal isoforms was found in failing ventricles compared with controls.
TETANUS AS A COMPLICATION IN DRUG INEBRIETY
Authors: JOSEPH C. DOANE
Journal: JAMA (1924)

The medical literature discloses a great variety of interesting and unusual etiologic factors associated with the development of tetanus. Not a few writers have ascribed the implantation of<i>Bacillus tetani</i>to the hypodermic injection of various medicaments. The hypodermic use of gelatin, as a hemostatic agent, is reported to have given rise to tetanus in no small number of cases. The subcutaneous administration of diphtheria antitoxin is also said to have resulted in the development of tetanus. Tetanus in the drug addict, however, is of extreme rarity, if one may judge from the paucity of reported cases. The first reference that appears in the literature, to my knowledge, is an editorial note<sup>1</sup>in the<i>Lancet</i>in December, 1876, in which the death from tetanus of a female addict, after using a rusty needle in the self-administration of morphin, is recorded. Melden,<sup>2</sup>in 1879, reported a postmortem examination, performed
A Totally Implanted Injection Port System for Blood Sampling and Chemotherapy Administration
Authors: John W. Gyves, William D. Ensminger, John E. Niederhuber, Thomas Dent, Suzette Walker, Susan Gilbertson, Edith Cozzi, Patricia Saran
Journal: JAMA (1984)

We evaluated a totally implanted system consisting of a subcutaneous injection port connected to a silicone elastomer central venous catheter for vascular access, including blood drawing, in 35 patients with cancer. All patients lacked peripheral venous access sites and were undergoing aggressive chemotherapy programs. The cumulative duration of successful access exceeded 2,900 days (for individual patients: range, five to 203 days; median, 61 days). In no instance were infusions or injections unsuccessful. Blood-sampling attempts were successful 90% of the time. The system did not require flushing between uses, being filled with heparinized saline after each entry. There were no instances of irreversible catheter occlusion or shear and no system-related infections. Thus, this device appears to have advantages over other central venous catheters in terms of patient acceptance and lack of maintenance between uses.
The Rebirth of Isabelle
Authors: Richard A. Parker
Journal: Annals of Internal Medicine (2000)

On Being a Patient5 December 2000The Rebirth of IsabelleRichard A. Parker, MDRichard A. Parker, MDDr. Parker: Beth Israel Deaconess Medical Center; Boston, MA 02215Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-11-200012050-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail She was born at home like the first child, but her eyes looked different, slightly glazed. At first, everything seemed normal. She fed, cried, and slept. But all was not right.The pregnancy had proceeded happily and uneventfully. A midwife herself, my wife Chrissie had taken excellent care of her health and prenatal nutrition. In the third trimester, her weight gain and the fundal height had leveled off—the first sign of a developmental problem. Isabelle's small size at birth, 6 pounds, 3 ounces, surprised us. This baby seemed birdlike, and my wife described her as an “ethereal being”—there and not ... Author, Article, and Disclosure InformationAffiliations: Dr. Parker: Beth Israel Deaconess Medical Center; Boston, MA 02215Corresponding Author: Richard A. Parker, MD, Beth Israel Deaconess Medical Center, 1 Autumn Street, Boston, MA 02215; e-mail, [email protected]harvard.edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLife on the Receiving End: A Qualitative Analysis of Health Providers??? Illness Narratives 5 December 2000Volume 133, Issue 11Page: 917-919KeywordsBehaviorBrainChildrenChocolateEmotionsFearMilkNeurologyNeuronsPregnancy ePublished: 5 December 2000 Issue Published: 5 December 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
War service and NHS pensions
Authors: R. V Goodliffe
Journal: BMJ (1978)

discharged no matter how overcrowded the hospital might have been.(5) The complaint is primarily against the authority and not against the individual doctor.Of course the Select Committee said it would have been "appropriate" for the commissioner to have contacted the doctor and that the authority should have done so initially, and they "note" that the authority did not contact the doctor when the draft report was submitted for comment.But they confirmed the decision and they confirmed it without contacting the doctor themselves.Meanwhile, in America, the senior house officer comes off best.He now lives in a country where all men can defend themselves if complaints are made against them.But we don't.
Abstract 591: Licochalcone E inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in the BALB/c mouse orthotopic model
Authors: So Young Park, SooJin Kwon, Jae Ho Jeon, Jong Gab Jun, Jung Han Yoon Park
Journal: Cancer Research (2012)

Abstract Licochalcone E a phenolic constituent of licorice that is reported to exert excellent anti-cancer effects. In the present study, to investigate the effect of licochalcone E oral administration on the solid tumor growth and metastasis of breast cancer cells, 4T1 cells were injected into the inguinal mammary fat pads of syngeneic female BALB/c mice. One week after the injection the mice were subjected to oral gavage for 25 days with licochalcone E (0, 7, or 14 mg/kg body weight/day). Licochalcone E treatment induced a significant reduction in solid tumor growth, which was accompanied by 1) reduced Ki67 (prototypic cell cycle related nuclear antigen), cyclin-dependent kinase (CDK)2, CDK4, cyclin A, and cyclin D1 and 2) increased numbers of TUNEL-positive apoptotic cells with increased Bax and cleaved caspase-3 expression but reduced Bcl-2 expression in tumor tissues. Licochalcone E also reduced the expression of hypoxia inducible factor (HIF)-1α, vascular endothelial growth factor (VEGF), VEGF-R2, CD31 (platelet endothelial cell adhesion molecule-1), VEGF-C and LYVE-1 (lymphatic vessel endothelial receptor-) in tumor tissues. In addition to tumor growth, oral licochalcone E administration markedly reduced the number of pulmonary tumor nodules. In lung tissues, licochalcone E induced a significant reduction in the levels of cytokines and angiogenesis-related proteins including DPPIV (CD26), endoglin (CD105), MMP-9, C5a, interleukin (IL)-1ra, IL-16, MIG (CXCL9). In vitro culture studies showed that licochalcone E dose-dependently inhibited the migration of MDA-MB-231 human breast cancer cells at concentrations of 0-20 μmol/L without significant changes in cell viability. Licochalcone E significantly reduced secretion of matrix metalloproteinase-9, urokinase-type plasminogen activator and VEGF in concentration-dependent manners in MDA-MB-231 cells. These results demonstrated that licochalcone E inhibits solid tumor growth and metastasis of breast cancer cells and these effects were mediated via the reduction of a wide variety of cytokines and chemokines, which subsequently inhibits tumor angiogenesis, lymphangiogenesis, proliferation, and metastasis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 591. doi:1538-7445.AM2012-591
Supporting junior faculty in the academic system: time for a change?
Authors: Andrew R. Marks
Journal: Journal of Clinical Investigation (2006)

Recently, MIT professor and Nobel laureate Susumu Tonegawa has come under attack for allegedly opposing the recruitment of a female, prospective junior faculty member to MIT because her work would compete with that of his laboratory. While the accusations are still under internal investigation, this incident raises the important issue of how we scientists as a group succeed or fail as mentors for junior faculty.
Cardiologists urge screening of asymptomatic older people
Authors: Fred Charatan
Journal: BMJ (2006)

An international group of prominent cardiologists has called for non-invasive screening for heart disease of all US asymptomatic men aged 45-75 and women aged 55-75.

The Screening For Heart Attack Prevention And Education (SHAPE) task force says that screening should be carried out to measure coronary artery calcium, with computed tomography scan, and carotid intima media thickness and plaque, with carotid ultrasonography.

The group's recommendations were published as a supplement to the American Journal of Cardiology in July, with Pfizer as the major sponsor.

The proposal hinges on the basic principle that traditional risk factor screening—the Framingham …
A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren's syndrome
Authors: Mihir Shah, Maria C. Edman, Srikanth R. Janga, Pu Shi, Jugal Dhandhukia, Siyu Liu, Stan G. Louie, Kathleen Rodgers, J. Andrew MacKay, Sarah F. Hamm-Alvarez
Journal: Journal of Controlled Release (2013)
Behavioral treatment of obesity. Limitations and results with the chronically obese
Authors: H. Currey
Journal: JAMA (1977)

Results of behavioral treatment for obese persons during the first 18 months of clinical operation are presented and other reports in the literature are reviewed. Baseline and follow-up data were gathered from a population of 144 female, chronically obese patients, most of whom were experiencing medical complications associated with obesity. Treatment results were disappointing in comparison with results of similar programs. Difference in patient population groups is offered as a possible explanation for this phenomenon. Covariant analyses of demographic and psychosocial variables failed to yield any clear predictors of weight loss; it is suggested that biological factors may be important to treatment outcome for some overweight patients.
A flipped forward view for healthcare
Authors: C. Brizzell
Journal: BMJ (2014)

The recent publication of the NHS’s Five Year Forward View by NHS England’s chief executive, Simon Stevens, has been described as “radical” by some reports. One proposal is that general practices would offer many of the services currently confined to hospitals. It is generally agreed that it will be a “huge challenge” to deliver what has been outlined in the five year time scale (doi:10.1136/bmj.g6484).

Apart from Stevens’s call to political parties for a major increase in funding to fill an £8bn gap, he also proposes a focus on “unleashing innovation and improvement” by finding new ways to tap into three sources of …
Diagnostic utility of elevated serum soluble triggering receptor expressed on myeloid cells (sTREM)-1 in infected neonates
Authors: Kosmas Sarafidis, Vasiliki Soubasi-Griva, Kaliopi Piretzi, Agathi Thomaidou, Eleni Agakidou, Anna Taparkou, Elisavet Diamanti, Vasiliki Drossou-Agakidou
Journal: Intensive Care Medicine (2010)
Payment Reform — The Need to Harmonize Approaches in Medicare and the Private Sector
Authors: Peter V. Lee, Robert A. Berenson, John Tooker
Journal: New England Journal of Medicine (2009)

In the midst of heated debate over health care reform, there is an emerging consensus that the way we pay for health care — with our widespread reliance on fee-for-service payment models — is a core problem that must be fixed. Unfortunately, too many of the policies proposed as part of reform seem to reflect the magical thinking that if we only “change Medicare” then all will be right in the world. Medicare is indeed the largest purchaser of health care in the United States, but at $414 billion out of almost $2.4 trillion, it represents only 19% of total . . .
We're all going to die. Deal with it
Authors: T. Delamothe, M. Knapton, E. Richardson
Journal: BMJ (2010)

Osteoporosis is serious, common and potentially preventable. In hospitals it most frequently presents as fracture of the hip or forearm; hip fractures alone occur in about 40,000 people each year in England and Wales, with a mortality of 15% and in-patient costs of approximately £200 million.<sup>1</sup> Vertebral fractures are even more common, causing deformity and pain, but reliable figures for morbidity and cost are not available. Didronel PMO (etidronate + calcium; Norwich Eaton) has recently been introduced for the ‘treatment of established vertebral osteoporosis’.
345 BcI-2 overexpression in human activated hepatic stellate cells: A survival and pro-fibrogenic mechanism
Authors: S. Cannito, E. Novo, E. Zamara, L. Valfrè di Bonzo, R. DeFranco, A. Mazzocca, S. Colombatto, E. Marra, R. Autelli, M. Pinzani, M. Parola
Journal: Journal of Hepatology (2006)
Lymphocytes, neuropeptides, and genes involved in alopecia areata
Authors: Amos Gilhar, Ralf Paus, Richard S. Kalish
Journal: Journal of Clinical Investigation (2007)

Many lessons in autoimmunity — particularly relating to the role of immune privilege and the interplay between genetics and neuroimmunology — can be learned from the study of alopecia areata, the most common cause of inflammation-induced hair loss. Alopecia areata is now understood to represent an organ-restricted, T cell–mediated autoimmune disease of hair follicles. Disease induction is associated with collapse of hair follicle immune privilege in both humans and in animal models. Here, the role of HLA associations, other immunogenetic factors, and neuroendocrine parameters in alopecia areata pathogenesis are reviewed. This instructive and clinically significant model disease deserves more widespread interest in the immunology community.
Founder of PIP breast implant company gets four year prison sentence
Authors: P. Benkimoun
Journal: BMJ (2013)

The founder of the breast implant company Poly Implant Prothese (PIP), Jean-Claude Mas, was convicted of aggravated fraud and sentenced to four years in prison and given a €75 000 (£63 000; $103 000) fine by a Marseilles criminal court on 10 December. 

The nearly 8000 page court decision said that “during more or less 10 years Jean-Claude Mas didn’t hesitate to sell breast implants containing a gel that hadn’t passed indispensable tests and analysis to prove …
TCTAP A-146 MicroRNA-21 Expression and its Association with Leukocytes Infiltration on the Early Phase of Coronary Microembolization
Authors: Zhangwei Chen, Jianying Ma, Juying Qian, Shufu Chang, Aijun Sun, Yunzeng Zou, Junbo Ge
Journal: Journal of the American College of Cardiology (2014)
Twelve-Month Follow-up of Cognitive Behavioral Therapy for Children With Functional Abdominal Pain
Authors: Rona L. Levy, Shelby L. Langer, Lynn S. Walker, Joan M. Romano, Dennis L. Christie, Nader Youssef, Melissa M. DuPen, Sheri A. Ballard, Jennifer Labus, Ericka Welsh, Lauren D. Feld, William E. Whitehead
Journal: JAMA Pediatrics (2012)

To determine whether a brief intervention for children with functional abdominal pain and their parents' responses to their child's pain resulted in improved coping 12 months later.Prospective, randomized, longitudinal study.Families were recruited during a 4-year period in Seattle, Washington, and Morristown, New Jersey.Two hundred children with persistent functional abdominal pain and their parents.A 3-session social learning and cognitive behavioral therapy intervention or an education and support intervention.Child symptoms and pain-coping responses were monitored using standard instruments, as was parental response to child pain behavior. Data were collected at baseline and after treatment (1 week and 3, 6, and 12 months after treatment). This article reports the 12-month data.Relative to children in the education and support group, children in the social learning and cognitive behavioral therapy group reported greater baseline to 12-month follow-up decreases in gastrointestinal symptom severity (estimated mean difference, -0.36; 95% CI, -0.63 to -0.01) and greater improvements in pain-coping responses (estimated mean difference, 0.61; 95% CI, 0.26 to 1.02). Relative to parents in the education and support group, parents in the social learning and cognitive behavioral therapy group reported greater baseline to 12-month decreases in solicitous responses to their child's symptoms (estimated mean difference, -0.22; 95% CI, -0.42 to -0.03) and greater decreases in maladaptive beliefs regarding their child's pain (estimated mean difference, -0.36; 95% CI, -0.59 to -0.13).Results suggest long-term efficacy of a brief intervention to reduce parental solicitousness and increase coping skills. This strategy may be a viable alternative for children with functional abdominal pain.clinicaltrials.gov Identifier: NCT00494260.
Desmoplastic Melanoma
Authors: Michael C. Roarke, Ba D. Nguyen, Barbara A. Pockaj
Journal: Clinical Nuclear Medicine (2008)

Desmoplastic melanoma is a rare subtype of malignant melanoma, which is unusual in that it is more often associated with local recurrence than with lymph node or distant metastatic spread. The histologic architecture of this melanoma subtype differs from conventional melanoma in that the melanoma cells are interspersed within an abundant collagenous stroma. We present a case that demonstrates both true positive and false negative findings on F-18 FDG PET/CT imaging in a case of recurrent desmoplastic melanoma.
P11. Developing an immunotherapy strategy for the effective treatment of patients with Non Small Cell Lung Cancer (NSCLC): strategies to evaluate immunity in patients on clinical trials
Authors: M Neuberger, C Paustian, T Hilton, N Engel, S Reu, A Linder, R Huber, R Hatz, H Winter
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Our centers have formed an international collaborative group composed of surgeons, pathologists, radiation oncologists, medical oncologists and immunologists working together with biotech and pharma sectors to evaluate biomarkers of immune status and develop effective combination