tbuckley/cabot-search huggingface dataset:
Risk of Cancer after Herpes Zoster
Authors: Mark W. Ragozzino, L. Joseph Melton, Leonard T. Kurland, Chu Pin Chu, Harold O. Perry
Journal: New England Journal of Medicine (1982)

Herpes zoster has been associated with immune suppression, as has an increased risk of cancer. To determine whether patients with herpes zoster are at increased risk for subsequent cancer, we followed 590 residents of Rochester, Minnesota, for 9389 person-years after the diagnosis of herpes zoster. Subsequent relative cancer risks, overall and by specific site, were determined for the entire cohort and selected subgroups. In addition, relative risks of cancer during various intervals after the diagnosis of herpes zoster were determined. The overall relative risk was 1.1 (95 per cent confidence interval, 0.9 to 1.3). Relative risks for specific cancer sites were not different from unity except for those for colon and bladder tumors in women, both of which were slightly elevated. Patients with disseminated, recurrent, or gangrenous zoster, with postherpetic neuralgia, and with ophthalmic zoster were not at elevated risk for subsequent cancer. These findings do not support the investigation of patients for occult cancer at the time of diagnosis of herpes zoster or enhanced surveillance for cancer after such a diagnosis. (N Engl J Med. 1982; 307:393–7.)
Personal reflections on efforts to reduce ischemic myocardial damage
Authors: E Braunwald
Journal: Cardiovascular Research (2002)

Background mortality by half [4], leaving pump failure associated with large infarction as a major challenge in cardiology.In the second half of the 19th Century, physiologists observed that ligation of a major coronary artery in the dog was immediately fatal.During that era, pathologists occa-2 .Early research sionally encountered thrombosis of such vessels and acute myocardial infarction (AMI) at autopsy, and consideredIn 1951, as a medical student at New York University this combination of findings to be quite uncommon and and Bellevue Hospital, I was introduced to cardiovascular uniformly fatal.At the dawn of the twentieth century, research in the hemodynamic laboratory of Ludwig Eich-Krehl, a Viennese physician, challenged these beliefs and na, a pioneer in the study of human heart failure.I reported that coronary thrombosis was actually compatible participated in some of the earliest measurement of cardiac with survival [1].In 1910, Obrastov and Strazheske [2],output in patients with cardiogenic shock secondary to two Russian physicians, and in 1912, Herrick, a Chicago AMI.During a postdoctoral fellowship in the Nobel Prize physician [3], described the clinical features of AMI, winning laboratory of Professors Andre Cournand and related them to the pathologic findings and distinguished Dickinson Richards in 1954-55, on the Columbia Uni-AMI from angina pectoris.Herrick also adapted the then versity Service of Bellevue Hospital, we studied patients new technique of electrocardiography to the premorbid with chronic congestive heart failure, many of whom had diagnosis of AMI, considered at the time to be a very previously suffered a MI.Therefore, by the time that I uncommon condition.
Proteomic analysis reveals a major role for contact inhibition in the terminal differentiation of hepatocytes
Authors: Carmine Mancone, Beatrice Conti, Laura Amicone, Veronica Bordoni, Carla Cicchini, Ludovica Calvo, Ariel Basulto Perdomo, Gian Maria Fimia, Marco Tripodi, Tonino Alonzi
Journal: Journal of Hepatology (2009)
Lung tumor NF-κB signaling promotes T cell–mediated immune surveillance
Authors: Emily L. Hopewell, Weipeng Zhao, William J. Fulp, Crystina C. Bronk, Alexis S. Lopez, Michael Massengill, Scott Antonia, Esteban Celis, Eric B. Haura, Steven A. Enkemann, Dung-Tsa Chen, Amer A. Beg
Journal: Journal of Clinical Investigation (2013)

NF-κB is constitutively activated in many cancer types and is a potential key mediator of tumor-associated inflammation, tumor growth, and metastasis. We investigated the role of cancer cell NF-κB activity in T cell–mediated antitumor responses. In tumors rendered immunogenic by model antigen expression or following administration of antitumor vaccines, we found that high NF-κB activity leads to tumor rejection and/or growth suppression in mice. Using a global RNA expression microarray, we demonstrated that NF-κB enhanced expression of several T cell chemokines, including Ccl2, and decreased CCL2 expression was associated with enhanced tumor growth in a mouse lung cancer model. To investigate NF-κB function in human lung tumors, we identified a gene expression signature in human lung adenocarcinoma cell lines that was associated with NF-κB activity level. In patient tumor samples, overall lung tumor NF-κB activity was strongly associated with T cell infiltration but not with cancer cell proliferation. These results therefore indicate that NF-κB activity mediates immune surveillance and promotes antitumor T cell responses in both murine and human lung cancer.
Fibrous hamartoma of infancy in a patient with Williams syndrome
Authors: T. Togo, E. Araki, M. Ota, T. Manabe, S. Suzuki, A. Utani
Journal: British Journal of Dermatology (2007)

Conflicts of interest: none declared. Sir, Fibrous hamartoma of infancy (FHI) is a benign soft tissue tumour composed of an organoid pattern of fibrous tissue, primitive mesenchyme and adipose tissue.1 Williams syndrome (WS) is a developmental disorder involving the cardiovascular and central nervous system. A rare disorder, WS is caused by a hemizygous microdeletion of 1·55 Mb spanning 26–28 genes on chromosome 7q11.23 including the elastin gene.2 Deletion of the elastin gene is responsible for a supravalvular aortic stenosis as well as soft texture and easy mobility of the skin. Here we present a case of FHI in a patient with WS. To our knowledge, the association of these two diseases has never been previously described. A 5‐year‐old boy with WS was referred because of an asymptomatic cutaneous lesion on the back that had been present since birth. On examination, an oval, pale‐pink, well‐circumscribed, elastic soft nodule with overlying coarse hairs was noted on the midline of the upper back. The nodule measured 55 mm in diameter and 22 mm in height (Fig. 1a). The centre of the nodule was brownish. The whole lesion was easily depressed on finger pressure.
Higher staff costs likely to tip many NHS trusts into red
Authors: M. Limb
Journal: BMJ (2014)

The NHS’s auditors have raised fresh concerns about the financial sustainability and resilience of many trusts. The Audit Commission, which monitors public spending in England, said that 19 of a total of 101 non-foundation trusts were referred to the health secretary for failing to meet their statutory duty to break even in 2013-14 (box). This compared with only six trusts in 2012-13.1

It said that auditors were reporting concerns about the “financial resilience” of a third of NHS trusts overall, up from a quarter in 2012-13. Marcine Waterman, the commission’s controller of audit, said, “This level of reporting is worrying and reflects the increasing risks to the financial sustainability of individual NHS trusts, as they continue to face sizeable financial pressures due to a rising demand for services …
Occult Systemic Lupus Erythematosus in Elderly Men
Authors: Alan N. Baer
Journal: JAMA (1983)

Systemic lupus erythematosus (SLE) is often not suspected in elderly men with a debilitating illness, particularly when pleuropericarditis is not prominent. Five elderly men with SLE were initially seen with a systemic illness, marked by fever, weight loss, and arthritis. The diagnosis of SLE was established after considerable delay with extensive diagnostic evaluations and was supported by the presence of DNA antibodies in four patients. Treatment with corticosteroids was effective in three patients. Early testing for DNA antibodies may be cost effective in the evaluation of the elderly patient with a debilitating illness.
Removing extreme poverty by 2015 is under threat
Authors: Zosia Kmietowicz
Journal: BMJ (2004)

More resources need to be put into basic health services for the world's most marginalised people if targets to alleviate extreme poverty agreed by world leaders 10 years ago are going to be met, says a report from the United Nations Population Fund.

And despite some progress in improving the quality and reach of reproductive health services in poor countries, more than 500 000 women continue to die each year from largely preventable complications of pregnancy and childbirth, according to the report.

Poverty is the main risk factor for obstetric complications. The chance of a woman dying in pregnancy or …
Selecting Revascularization Strategies in Patients with Coronary Disease
Authors: Robert A. Harrington
Journal: New England Journal of Medicine (2015)

The treatment of patients with coronary artery disease includes risk-factor modification (e.g., treatment of hypertension, hyperlipidemia, and diabetes) and some combination of medical therapies and coronary revascularization.1 For patients for whom revascularization is deemed to be appropriate, a decision must be made between percutaneous coronary intervention (PCI) and coronary-artery bypass grafting (CABG). In direct comparisons, CABG has been shown to be associated with fewer repeat revascularizations than PCI. However, questions have been raised about incremental improvements in stent technologies that might narrow the outcome gap between the two approaches. These improvements have included, first, the progression from bare-metal stents to . . .
Inhalation and nasal challenge in the diagnosis of aspirin‐induced asthma
Authors: A. PAWLOWICZ, W. R. WILLIAMS, B. H. DAVIES
Journal: Allergy (1991)

Inhalation and nasal aspirin challenge has been investigated in asthma patients with co‐existing rhinitis. Eight of 39 asthma patients were diagnosed as aspirin‐sensitive on the basis of inhalation challenge. Seven aspirin‐sensitive asthmatics were subjected to nasal aspirin provocation. During nasal challenge, all seven patients experienced a fall in FEV 1 of at least 15%, two showed a significant increase (&gt;400%) in nasal airways resistance (NAR) and one developed urticaria. No significant changes in FEV, or NAR were observed in nine normal subjects after aspirin inhalation and nasal challenge. There were no significant changes in FEV 1 or NAR in six aspirin‐tolerant asthmatics when aspirin was given intranasally. The results of this study show that aspirin nasal provocation impairs lung function in aspirin‐sensitive asthmatics. In comparison with inhalation challenge responses are generally milder and easier to control. Nasal challenge is also less time‐consuming than other methods of aspirin challenge and is therefore more suitable for routine use.
Contribution of ethanol and cigarette smoking to pulmonary dysfunction in chronic alcoholics.
Authors: D J Lyons, S V Howard, J S Milledge, T J Peters
Journal: Thorax (1986)

Ethanol is claimed to have a specific damaging effect on the lung and to be at least partially responsible for pulmonary dysfunction in alcoholics. Adequate allowance for the damaging effects of cigarette smoking has not, however, been made hitherto. Pulmonary function studies were undertaken in 27 alcoholic subjects. Although there was a high prevalence of symptoms and abnormalities of pulmonary function, these were largely confined to current smokers: most of those who had never smoked and the ex-smokers who were symptom free and had normal pulmonary function. A case controlled study of alcoholics and matched controls showed no significant difference in pulmonary function between the two groups. It is concluded that the high prevalence of respiratory disease in alcoholics is largely attributable to their smoking habits: no evidence of a specific pulmonary toxic effect of ethanol was identified in the study.
C-terminal <i>HERG</i> Mutations
Authors: Myriam Berthet, Isabelle Denjoy, Claire Donger, Laurence Demay, Hicham Hammoude, Didier Klug, Eric Schulze-Bahr, Pascale Richard, Harald Funke, Ketty Schwartz, Philippe Coumel, Bernard Hainque, Pascale Guicheney
Journal: Circulation (1999)

Background —The long-QT syndrome (LQTS) is a genetically heterogeneous disease in which 4 genes encoding ion-channel subunits have been identified. Most of the mutations have been determined in the transmembrane domains of the cardiac potassium channel genes KCNQ1 and HERG . In this study, we investigated the 3′ part of HERG for mutations. Methods and Results —New specific primers allowed the amplification of the 3′ part of HERG , the identification of 2 missense mutations, S818L and V822 M, in the putative cyclic nucleotide binding domain, and a 1-bp insertion, 3108+1G. Hypokalemia was a triggering factor for torsade de pointes in 2 of the probands of these families. Lastly, in a large family, a maternally inherited G to A transition was found in the splicing donor consensus site of HERG , 2592+1G-A, and a paternally inherited mutation, A341E, was identified in KCNQ1 . The 2 more severely affected sisters bore both mutations. Conclusions —The discovery of mutations in the C-terminal part of HERG emphasizes that this region plays a significant role in cardiac repolarization. Clinical data suggests that these mutations may be less malignant than mutations occurring in the pore region, but they can become clinically significant in cases of hypokalemia. The first description of 2 patients with double heterozygosity associated with a dramatic malignant phenotype implies that genetic analysis of severely affected young patients should include an investigation for &gt;1 mutation in the LQT genes.
819 COMPLETE NECROSIS AFTER TRANSARTERIAL CHEMOEMBOLIZATION COULD PREDICT PROLONGED SURVIVAL IN PATIENTS WITH INTRAHEPATIC RECURRENT HEPATOCELLULAR CARCINOMA AFTER CURATIVE RESECTION
Authors: J.H. Shim, K.M. Kim, Y.-J. Lee, S.-G. Lee, K.-B. Sung, Y.-S. Lim, H.C. Lee, Y.-H. Chung, Y. Lee, D.-J. Suh
Journal: Journal of Hepatology (2009)
Effect of propranolol and isoprenaline on regional left ventricular blood flow in experimental myocardial ischaemia
Authors: L. C. BECKER, R. FERREIRA, M. THOMAS
Journal: Cardiovascular Research (1975)

Journal Article Effect of propranolol and isoprenaline on regional left ventricular blood flow in experimental myocardial ischaemia Get access LEWIS C. BECKER, LEWIS C. BECKER 1 From the MRC Cardiovascular Research Unit, Royal Postgraduate Medical School, London 1British-American Fellow of the American Heart Association and British Heart Foundation. Present address: Cardiology Division, North Carolina Memorial Hospital, Chapel Hill, North Carolina, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar RAFAEL FERREIRA, RAFAEL FERREIRA From the MRC Cardiovascular Research Unit, Royal Postgraduate Medical School, London Search for other works by this author on: Oxford Academic PubMed Google Scholar MICHAEL THOMAS MICHAEL THOMAS From the MRC Cardiovascular Research Unit, Royal Postgraduate Medical School, London Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 9, Issue 2, March 1975, Pages 178–186, https://doi.org/10.1093/cvr/9.2.178 Published: 01 March 1975
The Effects of a Smoking Cessation Intervention on 14.5-Year Mortality
Authors: Gregory J. Bombassei
Journal: Annals of Internal Medicine (2005)

Letters18 October 2005The Effects of a Smoking Cessation Intervention on 14.5-Year MortalityGregory J. Bombassei, MDGregory J. Bombassei, MDFrom Avon, CT 06001.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-8-200510180-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Because Anthonisen and colleagues' report (1) dealt with the effectiveness and cost of a smoking cessation strategy, its end points were concerned with treatment differences between patients who were offered the smoking cessation intervention and those who were not. However, because I counsel patients in practice to quit smoking, I am even more interested in treatment differences between patients who actually quit smoking and those who continued to smoke, either continuously or intermittently. Knowing these data from a randomized clinical trial would improve my ability to inform my patients of the health benefits of smoking cessation.It ...Reference1. Anthonisen NR, Skeans MA, Wise RA, Manfreda J, Kanner RE, Connett JE, et al. The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Ann Intern Med. 2005;142:233-9. [PMID: 15710956] LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Gregory J. Bombassei, MDAffiliations: From Avon, CT 06001.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Effects of a Smoking Cessation Intervention on 14.5-Year Mortality Nicholas R. Anthonisen , Melissa A. Skeans , Robert A. Wise , Jure Manfreda , Richard E. Kanner , John E. Connett , and The Effects of a Smoking Cessation Intervention on 14.5-Year Mortality Nicholas R. Anthonisen The Effects of a Smoking Cessation Intervention on 14.5-Year Mortality Milan C. Mathew Metrics Cited byChange of Serum Inflammatory Cytokines Levels in Patients With Chronic Obstructive Pulmonary Disease, Pneumonia and Lung CancerPreconditioning: a paradigm shift in the biology of myocardial ischemiaCurrent awareness: Pharmacoepidemiology and drug safety 18 October 2005Volume 143, Issue 8Page: 615KeywordsConflicts of interestDeath ratesPatientsSmoking habits ePublished: 18 October 2005 Issue Published: 18 October 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Type E Botulism
Authors: Gordon A. Eadie, Joseph G. Molner, Robert J. Solomon, Richard D. Aach
Journal: JAMA (1964)

Three women became ill within a few hours after eating a common meal of tuna fish, bread, salad dressing, and coffee. One died 13 hours after onset; another died five days after onset; the third woman, who ate very little, survived a brief mild illness. The clinical diagnosis was botulism. This was confirmed by epidemiological, pathological, and laboratory studies, with the finding of type E<i>Clostridium botulinum</i>. The botulinus toxin came from the canned tuna fish. The exact manner of contamination of the tuna has not been found. Treatment consists of supportive therapy and type-specific antiserum. Though type E botulism has been much less common than types A or B in this country, it may become more frequent. It is recommended that a polyvalent antiserum, containing types A, B.<i>and E</i>, be made available in quantities sufficient to meet future emergencies. Clinical diagnosis of botulism must be made quickly and type-specific antiserum must be administered early, without waiting for bacteriological evidence.
Diet and Physical Activity Interventions in Severely Obese Adults—Reply
Authors: Bret H. Goodpaster
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Differential expression of Langerhans cells in the epidermis of patients with leprosy
Authors: M.F. GIMENEZ, IRMA GIGLI, F.A. TAUSK
Journal: British Journal of Dermatology (1989)

Eighteen patients with lepromatous leprosy (LL) showed a significant reduction (P < 0.001) of Langerhans cells (LC) irrespective of whether the biopsies were obtained from involved (398±186) or healthy skin (304±98). The cells showed morphological changes consisting mainly of loss of dendritic processes. Twenty‐four controls (age, sex and race matched) had a mean number of LC of 632±138. In tuberculoid patients (TT) significant differences were observed, depending on the site of biopsy. Nine biopsies from involved skin had 993±206 LC, whereas 11 from healthy skin had 448±96 (P < 0.001). This difference was confirmed in six additional borderline tuberculoid (BT) and TT patients in whom biopsies were simultaneouslyy obtained from involved (973±179) and uninvolved skin (498±99). In 10 patients with indeterminate leprosy the LC density did not differ from the control population (630±261). The expression of LC numbers in BT and TT patients may represent migration of these cells from healthy skin to involved areas or mobilization of a central pool. The low density found in LL patients could interfere with adequate presentation of mycobacterial antigens leading to tolerance. Alternatively the presence of T helper cells in TT infiltrates may produce factors that recruit LC; their absence in LL lesions may account for the decrease in LC expression.
Myocardial Dysfunction in Maternally Inherited Diabetes and Deafness
Authors: Sandra P. Silveiro, Luis Henrique Canani, Ana Luiza Maia, Jagdish W. Butany, Jorge L. Gross
Journal: Diabetes Care (2003)

The pattern and degree of myocardial involvement in maternally inherited diabetes and deafness (MIDD) is unclear (1–3). A recent French multicenter study that examined 54 patients with MIDD described left ventricular hypertrophy (LVH) in 8 and congestive heart failure (CHF) in 2 patients (2). Here, we reported a patient with mtDNA 3243 mutation who developed the full clinical, echocardiographic, and radiologic picture of CHF.

A 54-year-old man with diabetes since age 23 years was diagnosed as having MIDD based on the findings of deafness, familial history of diabetes, and short stature involving his younger brother and mother. His older brother also presented diabetes but not short stature or deafness. Insulin was started when the patient was age 38 years, and he never presented ketosis. …
A Clinical Treatise on Diabetes Mellitus.
Authors: Marcel Labbé, Labbé Marcel
Journal: JAMA (1923)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal