tbuckley/cabot-search huggingface dataset:
Adenoviral gene transfer of human renal V 2 vasopressin receptors improves contractility in cardiomyocytes
Authors: K.-L. Laugwitz, M. Ungerer, H.-J. Weig, K. Kronsbein, T. Schöneberg, K. Hoffmann, G. Schultz, A. Schörnig
Journal: Journal of the American College of Cardiology (1998)
Documenting Contributions to Authorship
Authors: G. B. John Mancini
Journal: Annals of Internal Medicine (1990)

Letters1 November 1990Documenting Contributions to AuthorshipG. B. John Mancini, MDG. B. John Mancini, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-9-723_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: The article by Dr. Fye (1) is a useful addition to the literature on the subject of authorship. Young investigators, however, are not inclined to prioritize the reading of such articles over those dealing with therapeutic and diagnostic advances. Moreover, trainees learn predominantly by seeing and imitating what their mentors and role models do. This process includes the development of attitudes toward authorship practices. Simply put, actions speak louder than words.I have tried to bring the authorship issue to light in a rather simple (simplistic?) way by requesting that all manuscripts be matched by a form...Reference1. Fye W. Medical authorship: traditions, trends, and tribulations. Ann Intern Med. 1990;113:317-25. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Michigan Medical School Ann Arbor, MI 48109-0366 Ann Arbor Veterans Affairs Medical Center Ann Arbor, MI 48105 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCommentary on “a proposal for a new system of credit allocation in science” 1 November 1990Volume 113, Issue 9Page: 723-723 Issue Published: 1 November 1990 PDF DownloadLoading ...
A Library for Internists
Authors: David A. Nardone
Journal: Annals of Internal Medicine (1991)

Letters1 October 1991A Library for InternistsDavid A. Nardone, MDDavid A. Nardone, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-7-579 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:The article by Ludmerer (1), "A Library for Internists VII," was indeed informative. I recognize that Dr. Ludmerer coordinated a multidisciplinary effort to complete the seventh edition of this work. As a practitioner of general internal medicine and a teacher of residents and medical students for over 20 years, I offer a slightly different model (Table 1). In this revision I have included several additional subcategories that I feel are worthy of note: Anesthesia; Obstetrics and Gynecology; Pathology; and Surgery grouped under "Other Specialties of Clinical Medicine"; Medical Malpractice; Quality Assurance; Symptoms, Signs, and (patient) Problems (for...References1. Ludmerer K. A library for internists VII: recommendations from the American College of Physicians. Ann Intern Med. 1991;114:811-32. LinkGoogle Scholar2. Fuller E. A system for filing medical literature: based on a method developed by Dr. Maxwell M. Wintrobe. Ann Intern Med. 1968;68:684-93. LinkGoogle Scholar3. Singer K. Where did I see that article? JAMA. 1979;241:1492-3. CrossrefMedlineGoogle Scholar4. . ICHPPC-2-defined: International Classification of Health Problems in Primary Care. 3d ed. New York: Oxford University Press; 1983. Google Scholar5. HaynesMcKibbonFitzgeraldGuyattWalkerSackett RKDGCD. How to keep up with the medical literature: VI. How to store and retrieve articles worth keeping. Ann Intern Med. 1986;105:978-84. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Veterans Affairs Medical Center Portland, OR 97207 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1991Volume 115, Issue 7Page: 579-580KeywordsAnesthesiaClinical pathologyHealth care quality assessmentLibrariesObstetrics and gynecologySigns and symptomsSurgery Issue Published: 1 October 1991 PDF DownloadLoading ...
Treating Adverse Effects of Verapamil
Authors: L. I. G. WORTHLEY
Journal: JAMA (1984)

To  Editor.—  InThe Journal, Morris and Goldschlager1describe a beneficial response to intravenous (IV) calcium chloride in a patient who had verapamil-induced hypotension, low cardiac output, and bradycardia. While they stated that reversal of these adverse effects outweighed any possible vasodilating effect of calcium chloride, they cautioned against its use by stating that the potential vasodilating effect of IV calcium chloride infusion (but not  gluconate, gluceptate, or lactate preparations) must be considered when using IV calcium to reverse adverse effects of verapamil, implying that these other preparations may be better.  When using calcium gluconate to reverse verapamil overdosage, some authors have reported a poor response.2,3Furthermore, when IV calcium gluconate is compared with calcium chloride,  body's retention of calcium is less,4extracellular ionized calcium increases less predictably,5and  positive inotropic effect of equimolar amounts is not as great.6  If a
Ethical Issues in Neurology
Authors: Donald J. Dalessio
Journal: JAMA (1995)

Right to death. Physician-assisted suicide. Euthanasia. Debate rages in the popular media regarding these topics. Derek Humphry's Final Exit , best described as a suicide manual for patients published by the Hemlock Society, is a best-seller. In several states, at least, there have been ballot initiatives best characterized as right to die. Nationwide polls suggest that some US citizens favor greater control over their circumstances at the end of life. The first document in the patient's chart is often a physician's directive giving explicit instructions regarding extent of treatment.   Ethical Issues in Neurology addresses all these issues from a professional perspective in a clear, comprehensive, and even-handed style. Furthermore, the book is actually interesting in contradistinction to so many papers on ethics, which manage to take the vibrant stuff of life and reduce it to boring technicalities. I was impressed that Bernat assembles the arguments pro and con but then offers
Impairment of selectin-mediated leukocyte adhesion to venular endothelium in spontaneously hypertensive rats.
Authors: M Suematsu, H Suzuki, T Tamatani, Y Iigou, F A DeLano, M Miyasaka, M J Forrest, R Kannagi, B W Zweifach, Y Ishimura
Journal: Journal of Clinical Investigation (1995)

The present study was designed to elucidate whether molecular mechanisms for leukocyte adhesion to microvascular endothelium may differ between spontaneously hypertensive rats and Wistar Kyoto rats. Leukocyte rolling and adhesion were investigated while monitoring venular wall shear rates in the mesenteric microcirculation stimulated with histamine or tert-butyl hydroperoxide in the two strains. In Wistar Kyoto rats, 10 microM histamine as well as 500 microM tertbutyl hydroperoxide promoted a significant reduction of venular leukocyte rolling velocity and subsequent adhesion. These changes in leukocyte behavior were blocked by monoclonal antibodies against P-selectin (PB 1.3) and against sialyl Lewis X-like carbohydrates (2H5). However, spontaneously hypertensive rats exhibited a blunted response of the stimulus-elicited leukocyte rolling, which was associated with impairment of venular P-selectin expression as well as a decrease in the expression of sialyl Lewis X-like carbohydrates on circulating neutrophils. No significant differences were detected between the two strains not only in the surface CD11b/CD18 expression but also in the CD18-mediated adhesivity of neutrophils to intracellular adhesion molecule-1 transfectants in vitro. These results suggest that impairment of selectin-mediated leukocyte adhesion is an event responsible for disorders of inflammatory responses in spontaneously hypertensive rats.
The Rational Treatment of Arterial Hypertension
Authors: Soma Weiss, Laurence B. Ellis
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Time for Revolutions — The Role of Clinicians in Health Care Reform
Authors: Ara Darzi
Journal: New England Journal of Medicine (2009)

William Beveridge, the economist whose 1942 report led to the founding of Britain's National Health Service (NHS), famously said that "a revolutionary moment in the world's history is a time for revolutions, not for patching."1 Given the combination of the global downturn and the time bomb that is health insurance costs, there is no denying that health care in the United States has reached such a moment. This matter is too important to be left to the politicians and policymakers; there is an urgent requirement for professional clinicians to step up and lead the debate.President Barack Obama has brought . . .
Crenolanib is active against models of drug-resistant FLT3-ITD−positive acute myeloid leukemia
Authors: Eric I. Zimmerman, David C. Turner, Jassada Buaboonnam, Shuiying Hu, Shelley Orwick, Michael S. Roberts, Laura J. Janke, Abhijit Ramachandran, Clinton F. Stewart, Hiroto Inaba, Sharyn D. Baker
Journal: Blood (2013)
Effect of altered activation sequence on epicardial QRST area and refractory period in dogs.
Authors: K Hanashima, I Kubota, T Ozawa, T Shibata, M Yamaki, K Ikeda, S Yasui
Journal: Circulation (1991)

BACKGROUND We investigated the effects of activation sequence on cardiac surface QRST areas and refractory periods in experiments on dogs. METHODS AND RESULTS Right and left ventricular pacings were performed, and the pacing site was altered every 6 minutes. After 4 minutes of a given pacing, 54 unipolar electrograms distributed over the entire cardiac surface were recorded. Next, refractory periods at electrode sites near pacing electrodes were measured. Paired right ventricular/left ventricular (RV/LV) pacing data were obtained six or seven times in each sample. Although the QRST isoarea maps during the two activation orders were qualitatively similar, it was recognized consistently from the right ventricle-left ventricle difference map that leads around the RV free wall had positive values and that leads around the LV free wall and apex had negative values. Compared with the same leads at RV and LV pacing, QRST areas were larger when pacing sites were near the leads. The local QRST areas of individual leads at which we measured local refractory period were consistently larger during drive from proximal pacing sites than during drive from distant pacing sites. Refractory periods were consistently longer during proximal pacing than during distal pacing, and there was a positive correlation between change in local QRST area and change in refractory period (r = 0.64) during altered activation sequence, whereas there was an inverse correlation between change in QRST area and change in refractory period (r = -0.91) during localized myocardial warming. CONCLUSIONS Both local QRST areas and local refractory periods were dependent on the activation sequence, and there was a positive correlation between QRST areas and refractory periods during various activation sequences compared with localized myocardial warming.
Genetic polymorphisms in the metabolic pathway and non‐Hodgkin lymphoma survival
Authors: Xuesong Han, Tongzhang Zheng, Francine M. Foss, Qing Lan, Theodore R. Holford, Nathaniel Rothman, Shuangge Ma, Yawei Zhang
Journal: American Journal of Hematology (2009)

Metabolic pathway enzymes, such as Cytochrome P450 (CYP), glutathione S-transferase (GST), and N-acetyltransferases (NAT) are involved in activation and detoxification of environmental carcinogens as well as drug metabolism. We hypothesized that the genetic variations in such metabolic pathways may affect NHL prognosis and survival. Follow-up information of 496 female NHL incident cases diagnosed during 1996-2000 in Connecticut were abstracted from the Connecticut Tumor Registry in 2008; survival analyses were conducted by comparing the Kaplan-Meier curves, and hazard ratios (HR) were computed from the Cox Proportional Hazard models adjusting for demographic and tumor characteristics which were suggested by previous studies to be determinants of NHL survival. We identified six SNPs from four metabolism genes (CYP2E1, GSTP1, GSTT1, and NAT1) that were associated with NHL survival. Specifically, polymorphisms in GSTT1 were associated with follicular lymphoma survival; and polymorphisms in CYP2E1, GSTP1, and NAT1 were associated with survival of chronic lymphocytic leukemia/small lymphocytic lymphoma. Our study suggests that genetic polymorphisms in metabolic pathways may help improve the prediction of NHL survival and prognosis.
THE TECHNIQUE OF TENOTOMY OF THE OCULAR MUSCLES.
Authors: LEARTUS CONNOR
Journal: JAMA (1895)

It is desirable that both patient and operator be in good physical condition. The surgeon, his assistant, patient, instruments, and operating room should all be rendered as aseptic as possible, because asepsis is the fundamental principle of modern surgery, which no ophthalmologist can afford to disregard, even when doing an ocular tenotomy. The operator's hands should be washed with pure soap and hot water, by the aid of a hand brush, so as to loosen all bacteria and other infectious materials lodged on the skin, attached to the hairs, embedded in the mouths of the oil or sweat glands or under the finger nails. This loosened<i>débris</i>is best removed by running hot water. The face, and beard (if the operator have one), are cleansed with scrupulous care. When dried, the hands are soaked in bichlorid solution, 1 to 1000. The assistant and patient cleanse themselves in a similar manner.
Cytogenetic features of acute lymphoblastic and myeloid leukemias in pediatric patients with Down syndrome: an iBFM-SG study
Authors: Erik Forestier, Shai Izraeli, Berna Beverloo, Oskar Haas, Andrea Pession, Kyra Michalová, Batia Stark, Christine J. Harrison, Andrea Teigler-Schlegel, Bertil Johansson
Journal: Blood (2007)
Effect of purified staphylococcal alpha toxin on active sodium transport and aerobic respiration in the isolated toad bladder
Authors: James J. Rahal, Martin E. Plaut, Louis Weinstein
Journal: Journal of Clinical Investigation (1968)

Purified staphylococcal alpha toxin was found to inhibit the active transport of sodium across the isolated toad bladder when applied to the serosal but not to mucosal surface. Heating or the addition of specific antitoxin abolished this effect. Low temperatures reduced this activity significantly. Application of vasopressin to the bladder serosa shortly after toxin resulted in only weak and transient stimulation of sodium transport; once maximal toxin activity had been established, exposure to the hormone was without effect. Transport in bladders previously stimulated by vasopressin was rapidly inhibited by alpha toxin. Concentrations that suppressed active sodium transport completely within 30-45 min produced a significant increase in oxygen consumption by minced bladder tissue within the same period; antitoxin neutralized this activity. 2,4-dinitrophenol also inhibited sodium transport and stimulated oxygen consumption by the toad bladder. The addition of 2,4 dinitrophenol to bladder tissue in which respiration was maximally stimulated by alpha toxin resulted in a further increase in respiratory rate. The addition of toxin to bladder tissue after its exposure to a concentration of 2,4 dinitrophenol known to uncouple oxidative phosphorylation produced a significant stabilization but no increment in respiratory rate. The data are consistent with the previously suggested action of staphylococcal alpha toxin on cell membranes and suggest that energy-dependent transport processes are inhibited. The stimulation of oxygen consumption may be due to an additional effect on oxidative phosphorylation.
Adding clopidogrel to aspirin did not reduce recurrent stroke and increased bleeding in lacunar stroke
Authors: Mike Manchak, Robert Holloway
Journal: Annals of Internal Medicine (2012)

ACP Journal Club18 December 2012Adding clopidogrel to aspirin did not reduce recurrent stroke and increased bleeding in lacunar strokeMike Manchak, MD, Robert Holloway, MD, MPHMike Manchak, MDUniversity of Rochester Medical Center, Rochester, New York, USA (M.M., R.H.)Search for more papers by this author, Robert Holloway, MD, MPHUniversity of Rochester Medical Center, Rochester, New York, USA (M.M., R.H.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-12-201212180-02002 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationSPS3 Investigators, Benavente OR, Hart RG, et al. Effects of clopidogrel added to aspirin in patients with recent lacunar stroke. N Engl J Med. 2012;367:817-25. https://pubmed.ncbi.nlm.nih.gov/22931315Clinical Impact RatingsGIM/FP/GP: Hospitalists: Neurology: References1 Furie KL, Kasner SE, Adams RJ, et al; American Heart Association Stroke Council, Council on Cardiovascular Nursing, Council on Clinical Cardiology, and Interdisciplinary Council on Quality of Care and Outcomes Research. Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42:227-76. [PMID: 20966421] Google Scholar2 Chimowitz MI, Lynn MJ, Derdeyn CP, et al; SAMMPRIS Trial Investigators. Stenting versus aggressive medical therapy for intracranial arterial stenosis. N Engl J Med. 2011;365:993-1003. [PMID: 21899409] Google Scholar3 Platelet-Oriented Inhibition in New TIA and minor ischemic stroke (POINT) trial. www.pointtrial.org (accessed 21 Oct 2012). Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Rochester Medical Center, Rochester, New York, USA (M.M., R.H.)This article was published at Annals.org on 4 December 2012. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 18 December 2012Volume 157, Issue 12Page: JC6-2KeywordsHemorrhageHemorrhagic strokeIschemic strokeMedical risk factorsPopulation statisticsStenosisStrokeTransient ischemic attacks ePublished: 18 December 2012 Issue Published: 18 December 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Significance of various type chromosome aberrations for man.
Authors: W W Nichols
Journal: Environmental Health Perspectives (1973)

A goal of mutagenicity testing is to de- velop a test that detects genetic damage and mutations with great sensitivity, and to have this test relevant to man.No test avail- able at the present time completely fulfills this goal, and a variety of compromises have been and continue to be made in test sys- tems.In considering cytogenetic techniques it is quite clear that these are excellent methods for detecting chromosomal abnormalities.Changes in chromosome number and trans- locations that can be heritable can be de- tected and are significant to the human pop- ulation.This is clear enough that it does not require further discussion.This does not mean that all details of this methodology are established, but there is no disagreement in the principle that cytogenetic tests can supply this information.In the present pa- per I would like to present three questions relating to the significance of cytogenetic abnormalities in which there is not uniform agreement.
Ocular Pathology: A Text and Atlas
Authors: J. Reimer Wolter
Journal: JAMA (1975)

Extensive knowledge of ocular pathology is an important part of the broad foundation that every ophthalmologist needs to gain true understanding of the clinically observed diseases of the eye. Much of the substance of this field, of course, is general pathology applied to the eye region. However, the combined efforts of pathologists with special interest in the eye, and of ophthalmologists with an understanding of pathology, have resulted in the accumulation of much specific knowledge and the creation of a pathological subspecialty that is equally important to ophthalmologists as well as pathologists and that is known as ocular or ophthalmic pathology. Progress made in this field has been unusually great and, thus, all books on the subject are either limited in their content or outdated. With an extremely concise text, excellent organization, and numerous well-selected illustrations, the present book is the complete and up-to-date guide that residents in ophthalmology and