tbuckley/cabot-search huggingface dataset:
Inherited ventricular arrhythmias and sudden death in German shepherd dogs
Authors: N.Sydney Moise, Vicki Meyers-Wallen, William J. Flahive, Beth A. Valentine, Janet M. Scarlett, Cynthia A. Brown, Matthew J. Chavkin, Dee A. Dugger, Shari Renaud-Farrell, Bruce Kornreich, William C. Schoenborn, Jennifer R. Sparks, Robert F. Gilmour
Journal: Journal of the American College of Cardiology (1994)

Objectives. This report describes a unique group of German shepherd dogs with inherited ventricular arrhythmias and sudden death. Before death, these dogs have no evidence of cardiovascular failure. Background. There are few spontaneous animal models of sudden death that permit intensive investigation. Methods. To determine the temporal evolution of ventricular arrhythmias and to characterize ihe syndrome of sudden cardiac death in these dogs, 24-h ambulatory electrocardiographic (ECG) monitoring, echocardiograms, electrophysiologic testing and breeding studies were conducted. Results. The 24-h ambulatory ECGs from dogs that died showed frequent ventricular arrhythmias with rapid polymorphic ventricular tachycardia (rates > 480 beats/min). Affected dogs had a window of vulnerability for arrhythmias, with the highest incidence and severity of arrhythmias between 20 to 30 and 40 to 50 weeks of age. Affected dogs that died did not have prolongation of the QT interval over a spectrum of heart rates compared with unaffected dogs. The clinical arrhythmia was not induced in dogs during programmed electrical stimulation. Severely affected dogs monitored > 5 years did not develop any evidence of heart failure or cardiomyopathy, and no histopathologic abnormalities existed. Seventeen dogs died suddenly (age 4 to 30 months) and were either 1) found dead at first observation in the morning (n = 8), 2) observed to die during sleep (n = 4), 3) observed to die while resting after exercise (n = 3), or 4) observed to die during exercise (n = 2). All sudden deaths occurred between the end of September and April, with most (n = 11) during January and February. Conclusions. The cause of the inherited severe ventricular arrhythmias and sudden death in these young German shepherd dogs is still undetermined. A purely arrhythmic disorder is supported by the lack of cardiac pathology. Moreover, the window of vulnerability to ventricular arrhythmias and the age and circumstances of death invite speculation about the role of the autonomic nervous system.
Zollinger-Ellison syndrome. Advances in treatment of gastric hypersecretion and the gastrinoma
Authors: R. T. Jensen
Journal: JAMA (1994)

Case 1  A 56-year-old man had an 8-year history of heartburn and diarrhea (three to four loose bowel movements a day) and a 3-year history of epigastric pain with two episodes of melena. Upper gastrointestinal endoscopy demonstrated a duodenal ulcer; however, no Helicobacter pylon was seen on the biopsy specimen. He was treated with ranitidine. Pain recurred when ranitidine administration was stopped. Despite visits to a number of physicians, the diagnosis of Zollinger-Ellison syndrome (ZES) was not made until 1 month before he was referred to the National Institutes of Health (NIH), when he was found to have an elevated fasting gastrin level and a gastric pH less than 2.5. Fasting gastrin at the NIH was elevated at 363 ng/L (normal,
Rape Crisis Centers-Reply
Authors: Catherine A. Martin
Journal: JAMA (1983)

<h3>In Reply.—</h3> We agree with Ms Burtness' comments about the importance of rape crisis centers. Physicians should investigate the availability of such centers in their communities. Unfortunately, rape crisis centers are not available in all areas. If available, the physician should mention the centers to the victim and stress their helpfulness. In addition, many victims may feel uncomfortable sharing their feelings in a group setting and will refuse to participate. In these situations, the ongoing support of the physician, family, and friends is particularly important in aiding the recovery of a rape victim.
Childhood Adversities as Risk Factors for Alexithymia and Other Aspects of Affect Dysregulation in Adulthood
Authors: Cornelis G. Kooiman, Sonja van Rees Vellinga, Philip Spinhoven, Nel Draijer, Rutger W. Trijsburg, Harry G.M. Rooijmans
Journal: Psychotherapy and Psychosomatics (2004)

Affect regulation is assumed to be a biologically based function that can become disrupted by inadequate parenting and by traumatic experiences. We studied the relation between the perceived parental parenting style, and sexual and physical abuse, with alexithymia, dissociation, anxiety and depression.In a cross-sectional study psychiatric outpatients were administered a structured interview on childhood physical and sexual abuse and they completed a number of questionnaires about the parenting styles of their parents, and about alexithymia, dissociation and mood pathology.Maternal and paternal parenting styles were moderately correlated with alexithymia and depression. The paternal parenting style was also correlated with dissociation. Optimal parenting of one of the parents had a buffering effect on the degree of alexithymia, but not on the severity of other forms of affect dysregulation. The effect of sexual or physical abuse did not add to that of parental parenting style in terms of predicting affect dysregulation. However, a positively perceived maternal parenting style was found to have a buffering effect in terms of the degree of alexithymia, if sexual abuse had also taken place.Perceived parenting does appear to be of some significance in the development of alexithymia. Optimal parenting of one of the parents may protect against the development of alexithymia when the parenting of the other parent is perceived as non-optimal. However, it is likely that other factors besides parental care and sexual or physical abuse play an important role in the development of an adequate affect regulation.
Poorer survival in women with advanced ovarian cancer explains the UK's lower overall survival
Authors: S. Mayor
Journal: BMJ (2012)

Poorer survival in women with advanced cancer accounts for the lower overall survival in women with ovarian cancer in the United Kingdom than in other countries, a new study shows.1 The authors said that this may be due to differences in the treatment of women with advanced disease.

Researchers from the International Cancer Benchmarking Partnership, a global collaboration that compares cancer survival in different countries, examined the records of 20 073 women who were given a diagnosis of ovarian cancer between 2004 and 2007 to assess how many survived for at least one year. They …
Timolol Topically and Diabetes Mellitus
Authors: Kristian Angelo-Nielsen
Journal: JAMA (1980)

<h3>To the Editor.—</h3> After reading the interesting case report by Stephen A. Shaivitz, MD (242:1611, 1979), about timolol maleate (Timacar) and myasthenia gravis, I happened to think of another occurrence that I had previously regarded as a coincidence in view of the small amount of timolol involved. <h3>Report of a Case.—</h3> A 72-year-old woman had a 13-year history of diabetes mellitus. During the past ten years the diabetes was labile, and she was treated with insulin. She often had hypoglycemia (one to four times a week), the symptoms of which she knew well that she terminated with milk or a similar substance. She also had been admitted five times with diabetic ketoacidosis, though never with hypoglycemia. She was otherwise in good health. In May 1978, timolol maleate therapy, 5 mg/mL, one drop two times a day in each eye, was started because of glaucoma. Three weeks later the patient was
The effects on atrial electrophysiology and structure of surgically induced right atrial enlargement in dogs.
Authors: P A Boyden, B F Hoffman
Journal: Circulation Research (1981)

We evaluated the relationship between susceptibility to arrhythmias caused by right atrial (RA) enlargement and alterations in transmembrane potentials and ultrastructure. RA enlargement was produced in eight dogs (TI) by excising the septal cusp of the tricuspid valve through a right atriotomy and constricting the pulmonary artery. This procedure resulted in RA dilation and hypertrophy. Four sham-operated dogs (S) also were studied. Neither TI nor S dogs developed spontaneous atrial arrhythmias. Atrial overdrive (OD) and premature stimulation (PS) were used to initiate and terminate arrhythmias. At 2 weeks and for 20 to 30 weeks after surgical preparation, TI dogs were more susceptible to arrhythmias than S dogs. The duration of arrhythmias exceeded 10 minutes more often in TI dogs than in S dogs. Sixty-one percent of all arrhythmias in the TI dogs had rates of 320-450 impulses/min, and electrogram and ECG characteristics of atrial flutter (type II rhythm), whereas no S dogs developed rhythms with these slower rates. The type II rhythms were persistent, 30% lasting longer than 30 minutes, while 22% lasted more than 60 minutes. Transmembrane potentials recorded in vitro from the RA free wall of TI dogs, and responses to norepinephrine and acetylcholine were not different from control. Histological and ultrastructural studies on TI atria showed hypertrophy of fibers and some increase in connective tissue between cells. These results suggests that altered susceptibility to long-lasting arrhythmias need not be associated with significant abnormalities of cellular electrophysiology.
Health of the Public: The Private-Sector Challenge-Reply
Authors: Nicole Lurie
Journal: JAMA (1996)

<h3>In Reply.</h3> —Drs Woloshin and Schwartz provide useful amplifications on our thesis that managed care organizations need to fulfill their social responsibility. Dr Lehman appears to be using the term "health care" in a rather narrow sense, that is, as the organizational mechanism that delivers health services. We believe that health care is a social good that is increasingly being distributed through market mechanisms. The challenge to the private sector is to implement policies that provide the principal investors in the health care system (taxpayers) with an adequate return on this investment. The
Abstract 4547: Clinical relevance of circulating tumor cells in esophageal cancer
Authors: Katharina E. Effenberger, Matthias Reeh, Sabine Riethdorf, Dominique Eichstaedt, Jakob R. Izbicki, Maximilian Bockhorn, Klaus Pantel
Journal: Cancer Research (2012)

Abstract Background: Current modalities to predict tumor recurrence and survival in esophageal cancer are insufficient. Locoregional and distant relapse is even common in lymph node-negative patients and more precise staging methods are therefore needed. Little is known about the utility of circulating tumor cells (CTC) as staging tool in esophageal cancer. Methods: In a prospective study we identified CTC in peripheral blood of esophageal cancer patients by two separate methods. We enrolled 85 consecutive esophageal cancer patients (03/2010-10/2011) who were surgically resected (R0) and patients received neither neoadjuvant nor adjuvant therapy. Peripheral blood was taken at the time of primary surgery and CTC were detected by either manual MACS enrichment (anti-cytokeratin plus anti-EpCam) with subsequent anti-cytokeratin staining or the automated CellSearch system (cleared by the FDA for CTC detection in metastatic breast, colon and prostate cancer) in parallel. CTC detection rates and correlation with clinicopathologic parameters were evaluated. The median clinical follow-up time is 11 months ranging from 1 to 19 months. Results: So far, 67 patients have been analysed of which 21 (31.3%) had CTCs using MACS, and 10 (14.9%) using CellSearch. CTCs detected with MACS significantly correlated with tumor size (p=0.040) and aggressive tumor biology as indicated by presence of regional lymph node (p=0.040) and distant metastases (p=0.019). CTCs detected with CellSearch correlated significantly with lymph node (p=0.044) and distant metastases (p=0.045), while no correlation was observed for tumor size or grading. CTC-positive patients had a worse overall survival than CTC-negative patients when tested with the CellSearch system (p=0.009). Conclusion: The presence of CTCs in patients with resectable esophageal cancer correlates with clinicopathologic risk factors.and predicts an unfavorable prognosis. Thus, our pilot study suggests that CTC detection may contribute to an improved staging in esophageal cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4547. doi:1538-7445.AM2012-4547
Double target for tumor mass destruction
Authors: Pipsa Saharinen, Kari Alitalo
Journal: Journal of Clinical Investigation (2003)

failure are progressive, it suggests that this counter-regulatory mechanism within the heart is limited and ultimately fails to provide long-term protection.Secondly, we must consider whether or not it will ultimately be beneficial or detrimental to treat (i.e., prevent) cardiac hypertrophy in response to pathologic conditions such as hypertension or valvular disease.In other words, would cardiac decompensation simply occur sooner if one blocks the hypertrophic phase of the response?
Amegakaryocytic Thrombocytopenia and an Analgesic
Authors: J. FONT
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 December 1981Amegakaryocytic Thrombocytopenia and an AnalgesicJ. FONT, M.D., B. NOMDEDEU, M.D., F. MARTINEZ-OROZCO, M.D., M. INGELMO, M.D., A. BALCELLS, M.D.J. FONT, M.D.Search for more papers by this author, B. NOMDEDEU, M.D.Search for more papers by this author, F. MARTINEZ-OROZCO, M.D.Search for more papers by this author, M. INGELMO, M.D.Search for more papers by this author, A. BALCELLS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-6-783_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Thrombocytopenia with decreased marrow megakaryoctyes as a pure hematologic syndrome is a rare clinical event that has been the subject of an article in your journal (1). The authors state that the differential diagnosis of this syndrome includes hereditary and acquired aplastic anemia, preleukemia, and systemic lupus erythematosus. We describe a patient with reversible drug-related thromocytopenia showing selective absence of marrow megakaryocytes.An 80-year-old white man had several costal fractures as a result of thoracic traumatism. As an analgesic a commercial combination of oxyphenbutazone and acetaminophen (paracetamol) was prescribed. The patient received it continously for 20 days...References1. STOLL D, BLUM S, PASQUALE D, and MURPHY S. Thrombocytopenia with decreased megakaryocytes: evaluation and prognosis. Ann Intern Med. 1981;94:170-5. LinkGoogle Scholar2. ARMSTRONG F and SCHERBEL A. Review of toxicity of oxyphenbutazone: report of a case of thrombocytopenic purpura. JAMA. 1961.175:614-5. CrossrefMedlineGoogle Scholar3. HEADING R. Purpura and paracetamol. Br Med J. 1968;3:743-4. CrossrefMedlineGoogle Scholar4. MIESCHER P and GRAF J. Drug-induced thrombocytopenia. Clin Haematol. 1980;9:505-19. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. FONT, M.D.; B. NOMDEDEU, M.D.; F. MARTINEZ-OROZCO, M.D.; M. INGELMO, M.D.; A. BALCELLS, M.D.Affiliations: Hospital Clinico Barcelona Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAcquired amegakaryocytic thrombocytopenic purpura: Review of a not very well-defined disorderHuman megakaryocytic progenitor cellsAplastic anemia occurring as amegakaryocytic thrombocytopenia with and without an inhibitor of granulopoiesis 1 December 1981Volume 95, Issue 6Page: 783-783KeywordsAnalgesicsAplastic anemiaBone marrowDrugsLupus erythematosusMegakaryocytes ePublished: 1 December 2008 Issue Published: 1 December 1981 PDF downloadLoading ...
In vitro and in vivo modulation of alpha- and beta-glucocorticoid-receptor mRNA in human bronchial epithelium.
Authors: S H Korn, E F Wouters, G Wesseling, J W Arends, F B Thunnissen
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Despite the central role bronchial epithelial cells play in asthmatic reactions, and the widespread use of inhaled corticosteroids in asthma, no information is available on the effect of glucocorticoids on glucocorticoid- receptor (GR) gene expression. In this study, the effect of budesonide on alpha- and beta-GR gene expression in human bronchial epithelial cells was investigated in vitro and in vivo. A bronchial epithelial cell line was exposed in vitro to budesonide, and a dose- and time-dependent synchronous downregulation of alpha- and beta-GR mRNA was observed. A 1-h exposure resulted in a reversible and reduced downregulation as compared with continuous exposure. In healthy volunteers (n = 10), no difference on average was present in GR mRNA expression before or after 4 wk of budesonide inhalation in either bronchial epithelial cells or alveolar macrophages. The time between the last inhalation and sampling of cells ranged from 0.5 to 8 h. However, a significant downregulation of alpha-GR mRNA was observed when the time between the last inhalation and sampling of cells was more than 2 h. Normalization of the downregulation of GR mRNA expression in bronchial epithelial cells is explained by the pharmacokinetics of inhaled budesonide in the human lung.
In-hospital and long-term mortality in male veterans following noncardiac surgery. The Study of Perioperative Ischemia Research Group
Authors: W. S. Browner
Journal: JAMA (1992)

<h3>Objectives.</h3> —To determine the causes of and risk factors for mortality following noncardiac surgery. <h3>Design.</h3> —Prospective cohort study. <h3>Setting.</h3> —A university-affiliated Veterans Affairs medical center. <h3>Patients.</h3> —Consecutive series of 474 men between the ages of 38 and 89 years (mean age, 68 years) who were undergoing major noncardiac surgery involving general anesthesia. All subjects had known coronary artery disease or were at high risk for coronary artery disease. <h3>Measurements and Results.</h3> —During the initial hospitalization, 26 patients (5%) died, most commonly from sepsis (n=6) or cardiac diseases (n=6). Deaths occurred from postoperative days 2 to 69; half occurred more than 3 weeks after surgery. Multivariable analysis disclosed that a history of hypertension (odds ratio [OR]=3.8; 95% confidence interval [Cl], 1.1 to 13), a severely limited activity level (OR=9.7; 95% Cl, 2.5 to 37), and a creatinine clearance of less than 0.83 mL/s (OR=6.8; 95% Cl, 2.8 to 16) were all independently associated with an increased risk of postoperative mortality. The mortality rate in patients with two or more of these risk factors was 20%, nearly eight times higher (95% Cl, 3.6 to 16) than those with one or no risk factors. An additional 82 patients died within the next 2 years; cancer, renal dysfunction, congestive heart failure, and obstructive pulmonary disease were independently associated with long-term mortality. <h3>Conclusions.</h3> —Even in patients at high risk of cardiac complications following surgery, noncardiac causes of death are more common. Patients with a history of hypertension, severely limited activity, and reduced renal function appear to be at especially high risk of in-hospital mortality after noncardiac surgery. (<i>JAMA</i>. 1992;268:228-232)
Acute Immunologic Pulmonary Alveolitis
Authors: Kent J. Johnson, Peter A. Ward
Journal: Journal of Clinical Investigation (1974)

Acute immunologic injury of rat lung has been induced by the intrabronchial injection of heterologous antibody and the intravenous injection of radiolabeled antigen. Within 4 h an acute hemorrhagic neutrophil-rich exudate develops in alveolar and interstitial areas and then gradually fades. Lung injury in this model can be quantitated by measurements of increased vascular permeability and extractable hemoglobin. By the use of immunofluorescent techniques, alveolar and interstitial deposits of antigen and antibody have been demonstrated, but not the third component of complement (C3). Although not found in relation to immune complexes, C3 is nevertheless present in damaged lung as measured by accumulation of radiolabeled C3 from the circulation. Ablation experiments indicate the requirement for both circulating neutrophils and C3 for the development of lung injury. These studies provide definition for the development of lung damage induced by immune complexes.
Allergenic cross‐reactivity of olive pollen
Authors: E. M. González, M. Villalba, R. Rodríguez
Journal: Allergy (2000)

Sera of patients allergic to olive (Olea europaea) pollen were used to analyze the IgE cross-reactivity between olive-pollen extract and other pollens obtained from phylogenetically unrelated species.We used IgE immunostaining of pollen extracts blotted to nitrocellulose membranes after SDS-PAGE and inhibition analysis of this binding.A high inhibition of the IgE binding on olive-pollen extract was exhibited by birch, mugwort, pine, and cypress pollens, suggesting that these extracts contain proteins which share common epitopes and thus can be recognized by olive-allergic sera. IgE binding to Gramineae pollen extracts was not inhibited by olive-pollen extract, indicating a primary sensitization of the patients to these species. From the inhibition assays, the presence of an allergen of 45 kDa in the olive pollen, which has no homologous counterparts in other allergenic species, has been inferred.Olive pollen contains allergens which cross-react with pollens from unrelated species, a fact that could simplify the diagnosis and treatment of pollinosis.
Ritual pathology and the nature of ritual culture
Authors: Bjorn Merker
Journal: Behavioral and Brain Sciences (2006)

Boyer &amp; Lienard's (B&amp;L's) biological model of ritual achieves a rather straightforward account of features shared by ritual pathology and the idiosyncratic rituals of children; but complexities accrue in extending it to human ritual culture generally. My commentary suggests that the ritual cultural traditions of animals such as songbirds share structural features, handicap-based origin, as well as the enabling neural mechanism of vocal learning with human ritual culture.
CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes
Authors: Luisa Granziero, Paola Circosta, Cristina Scielzo, Elisa Frisaldi, Stefania Stella, Massimo Geuna, Silvia Giordano, Paolo Ghia, Federico Caligaris-Cappio
Journal: Blood (2003)