tbuckley/cabot-search huggingface dataset:
Superhigh-magnetization nanocarrier as a doxorubicin delivery platform for magnetic targeting therapy
Authors: Mu-Yi Hua, Hung-Wei Yang, Hao-Li Liu, Rung-Ywan Tsai, See-Tong Pang, Kun-Lung Chuang, Yu-Sun Chang, Tsong-Long Hwang, Ying-Hsu Chang, Heng-Chang Chuang, Cheng-Keng Chuang
Journal: Biomaterials (2011)
The Incomplete Antibody in Rh Immunization
Authors: R. R. Race, G. L. Taylor
Journal: BMJ (1944)

SUCCESSFUL REMOVAL OF TERATOMA BMEITISHand outwards along the sixth rib.The costal cartilages were cut on the bevel to prevent overlapping when the chest was closed.The right pleural sac was stripped away and a window raised of chest wall.This revealed a large yellowish-white tumour, which was found to be relatively free on blunt dissectior below, but was more firmly attached towards the upper pole.Owing to its.large size it would have been necessary to enlarge the opening in the chest; so, to overcome this difficulty, the tumour was reduced in
Increased Suicide Rate in the Middle-Aged and Its Association With Hours of Sunlight
Authors: Gavin Lambert, Christopher Reid, David Kaye, Garry Jennings, Murray Esler
Journal: American Journal of Psychiatry (2003)

Aside from diminished daily functional capacity, individuals with depression are at greatly higher risk of suicide. Given that both endogenous depression severity and the incidence of suicide peak during the spring and summer months, it would seem that an environmental cue-one that generates alterations in brain neuronal activity that result in depressed affect or suicidal ideation-might be important.The authors examined the frequency of suicide and its relation to meteorological factors in the state of Victoria between January 1990 and April 1999.The incidence of suicide had its nadir in winter and zenith in the spring and summer and paralleled closely the number of bright sunlight hours. This pattern was particularly marked for violent suicide. During the decade, the suicide rate significantly increased among men between 21 and 60 years of age and women between 41 and 60.The incidence of suicide in southeastern Australia displays a clear seasonal pattern, being positively linked with prevailing levels of sunlight. The rate of suicide increased in the latter half of the last decade.
Hydronephrotic Ectopic Pelvic Kidney Simulates Sacral Metastasis From Breast Cancer
Authors: Daniel A. Pryma, Tim Akhurst
Journal: Clinical Nuclear Medicine (2005)

A 57-year-old woman with a history of a right modified radical mastectomy after neoadjuvant chemotherapy for stage IIIB infiltrating ductal breast carcinoma presented for follow-up bone scan. Initial inspection was suspicious for sacral metastasis, but on closer review the absence of renal activity in the left flank was noted. Correlation with CT scan confirmed a hydronephrotic ectopic kidney overlying the sacrum.
Statistics and ethics in medical research.
Authors: M R Clarke
Journal: BMJ (1981)

ence of one of us (SLS) in over 500 suprapubic catheterisations for postoperative bladder drainage bowel perforation has occurred on only one occasion, and was satisfactorily managed as we described.We take Miss Senapti's point that the use of a catheter with an adjustable flange may lead to urinary extravasation if the catheter is not inserted well into the bladder.Indeed, we see this as one of the advantages of the Bonanno catheter, which is our preferred instrument, since its flanges are fixed some 17j cm from the proximal side hole.
Variation adds value to the author's logic
Authors: A. Dixon
Journal: BMJ (1997)

A primary research article purports to be an objective record of a discrete piece of work that addresses, in sequence, the introduction of the problem at issue, the approach and methods adopted, the results, and the conclusions to be drawn. One of the key questions for publishers of scientific papers is whether and how one can retain the author's logic but also provide the variety, segmentation, and ancillary information that electronic publishing can allow, and which end users may want.

But firstly let's look at the work of scientists themselves. In five years' time it will be almost inconceivable that some part of their work, or more likely all of it, will not have been created using computing power. The output could be data, tables, pictures, texts, sound, images, animations, computable formulas, three-dimensional movable …
SUPRARENALECTOMY IN ESSENTIAL HYPERTENSION
Authors: David Ayman
Journal: JAMA (1934)

<h3>To the Editor:—</h3> InThe Journal, April 7, page 1118, the results of suprarenalectomy in essential hypertension are reported. It seems to me that the therapeutic importance of this paper is lost by the failure of the authors to control adequately their studies of the blood pressure. Thus, patient 1 entered their clinic apparently for the first time, Oct. 7, 1933, and on October 17, after ten days' observation, was operated on. Such a brief period of observation is of little value in determining the effect of subsequent therapy. Weeks and even months of careful observation under standard conditions are needed in any study of essential hypertension. The truth of this statement is illustrated by the following case: M. R., aged 55, was first seen with a blood pressure of 240 systolic, 130 diastolic, which dropped at the end of twenty minutes' rest in a chair to 190 systolic, 120
Neurobiological bases of aggression, violence, and cruelty
Authors: María Inés de Aguirre
Journal: Behavioral and Brain Sciences (2006)

Aggression, violence, and cruelty are symptoms of psychiatric illness. They reflect abnormalities in the regulation of the stress and emotion circuitries. The functioning of these circuitries depends upon the interaction between genetics and environment. Abuse and neglect during infancy, as well as maternal stress and poor quality of maternal care, are some of the causes that produce these types of abnormal behavior. Research on the neurobiological bases of emotion regulation will allow the detection of the population at risk.
Abstract 17754: Accuracy of Dual Source Computed Tomography to Predict Suitable Angulations for Fluoroscopic Guidance During Transcatheter Aortic Valve Implantation (TAVI)
Authors: Stephan Achenbach, Stephan Ensminger, Ina Bauer, Josef Ludwig, Richard Feyrer, Werner G Daniel, Michael Weyand, Friedrich Einhaus, Mohamed Marwan, Holger Nef, Christian Hamm, Martin Arnold
Journal: Circulation (2011)

For Transcatheter Aortic Valve Implantation (TAVI), optimal selection of fluoroscopic projections is important and often requires multiple aortic angiograms in various angulations. We analyzed the ability of Dual Source CT (DSCT) to predict suitable angulations for fluoroscopy during the TAVI procedure, including influence on procedural parameters and contrast use. Methods: 75 consecutive patients who underwent TAVI using the Edwards-Sapien valve were evaluated. Possible angulations which would render an orthogonal view onto the aortic valve plane were determined by interactive evaluation of pre_procedural contrast-enhanced DSCT data sets acquired during i.v. injection of 40ml contrast agent. TAVI operators used a predicted angulation for the first aortic angiogram and performed additional aortic angiograms if no satisfactory view of the valve plane was obtained. Predicted angulations were compared to the angulation used for valve implantation. Differences of less than 5° (sum of LAO-RAO and CRAN-CAUD deviation) were considered as accurate prediction. Radiation exposure and contrast use was compared between patients with accurate prediction of fluoroscopic angulations by CT versus those in whom CT failed to predict a suitable view. Aortic valve calcifum was visually quantified in CT as mild, moderate, severe. Results: TAVI was successful in all 75 patients. The mean difference between the CT-predicted angulation and the angulation used for implantation was 3±6°. CT predicted a suitable angulation in 63/75 cases (84%). The number of aortic angiograms acquired in patients with correct prediction (1.02±0.1) was lower than in patients with incorrect prediction (3.0±1.7, p &lt; 0.001). Similarly, the amount of contrast agent required for the entire TAVI procedure was lower in patients with correct prediction (72±36ml vs. 106±39 ml, p = 0.001). Extensive calcifications of the aortic valve were associated with a lower frequency of correct prediction (100% for mild, 89% for moderate, and 71% for severe calcification, p = 0.03). Conclusion: CT allows prediction of suitable fluoroscopy angulations during TAVI in the majority of cases, which significantly reduces the required amount of contrast.
<sup>99m</sup> Tc-N-NOET Myocardial Uptake Reflects Myocardial Blood Flow and Not Viability in Dogs With Reperfused Acute Myocardial Infarction
Authors: Gérald Vanzetto, David K. Glover, Mirta Ruiz, Dennis A. Calnon, Roberto Pasqualini, Denny D. Watson, George A. Beller
Journal: Circulation (2000)

Background — N -Ethoxy- N -ethyl-dithiocarbamato-nitrido- 99m Tc ( 99m Tc-N-NOET) is a new neutral lipophilic 99m Tc-labeled myocardial perfusion agent with a high first-pass extraction fraction and delayed redistribution kinetics after transient ischemia comparable to what is observed with 201 Tl. It is unknown whether the uptake of this tracer reflects myocardial viability or just reperfusion flow in the setting of a reperfused myocardial infarction. Methods and Results —In 13 anesthetized open-chest dogs, the left anterior descending coronary artery was occluded for 180 minutes, followed by 180 minutes of reperfusion. 201 Tl and 99m Tc-N-NOET were injected after either 60 (group 1, n=9) or 175 (group 2, n=4) minutes of reperfusion. Myocardial blood flow was measured by radioactive microspheres, and 201 Tl and 99m Tc-N-NOET tissue activities were determined by gamma-well counting. Normalized myocardial blood flow in the central infarct zone fell from 0.80±0.03 (SEM) and 0.89±0.01 at baseline to 0.18±0.04 and 0.13±0.02 during the occlusion in groups 1 and 2, respectively. Normalized 201 Tl activity in these segments was 0.39±0.04 and 0.43±0.04 and reflected myocardial viability rather than reperfusion flow ( P &lt;0.001). Normalized 99m Tc-N-NOET activity in the same segments was 0.84±0.08 and 0.64±0.03, respectively ( P &lt;0.01 versus 201 Tl; P =NS versus reperfusion flow) and more accurately reflected reperfusion flow (0.99±0.17 and 0.70±0.04) than residual viability. Conclusions —The myocardial uptake of 99m Tc-N-NOET reflects reperfusion myocardial blood flow and not viability in a canine model of reperfused acute myocardial infarction. The clinical use of early 99m Tc-N-NOET imaging to assess the success of coronary reperfusion in patients with acute myocardial infarction should be investigated.
Bone Scan and Chemonucleolysis
Authors: SALVATORE AMICO, JEAN PAUL ESCHARD, JEAN CLAUDE LIEHN, JACQUES VALEYRE
Journal: Clinical Nuclear Medicine (1990)

This study is based on 20 patients who underwent bone scanning before and after chemonucleolysis (CN) for a herniated lumbar disk. It shows that chymopapain, the proteolytic enzyme used for CN, does not induce early or late bone lesions of the adjacent vertebral plates. Abnormal uptake by one of the vertebral plates indicates a "chemical discitis." The pattern observed on the bone scan is different from the one presented by patients with bacterial spondylitis.
THE IMPACT OF RIGHT VENTRICULAR LEAD POSITION ON RESPONSE TO CARDIAC RESYNCHRONISATION THERAPY IN PATIENTS WITH CONCORDANT AND DISCORDANT LEFT VENTRICULAR LEADS
Authors: Fakhar Z. Khan, Pegah Salahshouri, Munmohan S. Virdee, Peter J. Pugh, Philip A. Read, Simon P. Fynn, David P. Dutka
Journal: Journal of the American College of Cardiology (2010)
Safety, efficacy, and effect on glucose levels of once-daily niacin on patients with dyslipidemia
Authors: Rosario A. Mercado-Young, Liberty O. Yaneza, Swangjit Suraamornkul, Judith J. Nicastro, Shuko Lee, Robert J. Chilton, Robert A. O'Rourke
Journal: Journal of the American College of Cardiology (2003)
Effectiveness of Manual Physical Therapy and Exercise in Osteoarthritis of the Knee
Authors: Gail D. Deyle, Nancy E. Henderson, Robert L. Matekel, Michael G. Ryder, Matthew B. Garber, Stephen C. Allison
Journal: Annals of Internal Medicine (2000)

Background: Few investigations include both subjective and objective measurements of the effectiveness of treatments for osteoarthritis of the knee. Beneficial interventions may decrease the disability associated with osteoarthritis and the need for more invasive treatments. Objective: To evaluate the effectiveness of physical therapy for osteoarthritis of the knee, applied by experienced physical therapists with formal training in manual therapy. Design: Randomized, controlled clinical trial. Setting: Outpatient physical therapy department of a large military medical center. Patients: 83 patients with osteoarthritis of the knee who were randomly assigned to receive treatment (n = 42; 15 men and 27 women [mean age, 60 ± 11 years]) or placebo (n = 41; 19 men and 22 women [mean age, 62 ± 10 years]). Intervention: The treatment group received manual therapy, applied to the knee as well as to the lumbar spine, hip, and ankle as required, and performed a standardized knee exercise program in the clinic and at home. The placebo group had subtherapeutic ultrasound to the knee at an intensity of 0.1 W/cm2 with a 10% pulsed mode. Both groups were treated at the clinic twice weekly for 4 weeks. Measurements: Distance walked in 6 minutes and sum of the function, pain, and stiffness subscores of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). A tester who was blinded to group assignment made group comparisons at the initial visit (before initiation of treatment), 4 weeks, 8 weeks, and 1 year. Results: Clinically and statistically significant improvements in 6-minute walk distance and WOMAC score at 4 weeks and 8 weeks were seen in the treatment group but not the placebo group. By 8 weeks, average 6-minute walk distances had improved by 13.1% and WOMAC scores had improved by 55.8% over baseline values in the treatment group (P < 0.05). After controlling for potential confounding variables, the average distance walked in 6 minutes at 8 weeks among patients in the treatment group was 170 m (95% CI, 71 to 270 m) more than that in the placebo group and the average WOMAC scores were 599 mm higher (95% CI, 197 to 1002 mm). At 1 year, patients in the treatment group had clinically and statistically significant gains over baseline WOMAC scores and walking distance; 20% of patients in the placebo group and 5% of patients in the treatment group had undergone knee arthroplasty. Conclusions: A combination of manual physical therapy and supervised exercise yields functional benefits for patients with osteoarthritis of the knee and may delay or prevent the need for surgical intervention.
Neurological Complications of Mumps
Authors: J. Macrae, A. M. G. Campbell
Journal: BMJ (1949)

URETHRITIS TREATIED WITH AUREOMYCINsHDIC Jo 259was given four capsules of aureomycin in divided doses over 20 hours (1,000 mg.).When seen two days later the discharge had gone and the urine was completely clear apart from some threads in the first glass; the inguinal adenitis had entirely subsided.The urethral smear showed no pus cells, and the culture was negative for gonococci.He did not trouble to attend again until the 26th day, when he had no discharge, his urine was clear, and his prostatic secretion was free from pus.
Kenneth McIntyre MacLeod
Authors: B. J Kirby
Journal: BMJ (2009)

Dr Ken MacLeod died suddenly on 11 July while playing tennis with friends. He was aware that he had hypertrophic obstructive cardiomyopathy. Ken was one of Britain’s leading experts in diabetes and a leader in medical education.

Research into hypoglycaemia was one of his central interests, though his boundless energy led him into many other areas, as well as seeking improvements in all aspects of diabetes from care for individual patients to finding ways to improve services for everyone with the condition. A good illustration of his ability to combine research with service development was in his recently published work showing that diabetic patients were no more dangerous car drivers than the rest of us. Recognition of his work in health service provision came by appointments to committees of the Departments of Health and Transport concerned nationally with improvements for diabetic patients.

His other major contribution was in medical education. He felt passionately about the need to preserve the traditional teaching of clinical skills but in combination with modern developments in medical education. Once more, this …
Failure of Information as an Intervention to Modify Clinical Management: A Time-Series Trial in Patients with Acute Chest Pain
Authors: Thomas H. Lee
Journal: Annals of Internal Medicine (1995)

Objective: To test whether a low-intensity, nonintrusive intervention improved the efficiency of management of patients with acute chest pain. Design: Time-series trial with six 14-week cycles, each including a 5-week intervention period and a 5-week control period separated by 2-week "washout" periods. Setting: Urban teaching hospital. Patients: 1921 patients aged 30 years or older with acute chest pain unexplained by local trauma or chest radiograph. Intervention: Risk estimates and triage recommendations were made available to physicians at the time of emergency department evaluation and, for hospitalized patients, on a daily basis before morning rounds. Flowsheets and stickers, but no direct human contact, were used to transmit this information. Measurements: Rates of admission to the hospital and coronary care unit, inpatient costs, and lengths of stay. Results: Rates of admission during intervention and control periods were similar in both the hospital (52% and 51%, respectively) and the coronary care unit (10% and 10%, respectively). Total lengths of stay in the hospital were similar (4.9 ±5.9 days and 4.9 ±5.7 days, respectively), as were average total costs ($7822 ±$13 217 and $7955 ±$13 400, respectively). No differences in management were detected for the subgroup of patients with low clinical risk for acute myocardial infarction. Conclusions: The use of information alone—without direct human contact—did not affect management of patients with acute chest pain at this hospital. Although this low-intensity intervention might be more effective for other conditions and in other settings, our data support the use of other strategies to affect physician decision making.
Abnormal Gallium Uptake in Anticardiolipin Syndrome
Authors: WALTER E. DRANE, BRIAN J. KELLY, KEVIN MCCULLUM
Journal: Clinical Nuclear Medicine (1988)

A case of asymmetrical gallium uptake in the musculature of a young woman with anticardiolipin syndrome is reported. The patient was asymptomatic in the areas of involvement, muscle biopsy was normal, and the abnormal gallium accumulation was unchanged on repeat evaluation 7 months later. Possible causes for the abnormal gallium uptake are proposed, but the mechanisms of uptake in this case remain unclear. Nuclear physicians should be aware of this disorder and the potential for abnormal gallium uptake with this syndrome.
Lipoprotein (a) binds and inactivates tissue factor pathway inhibitor: a novel link between lipoproteins and thrombosis
Authors: Noel M. Caplice, Carmelo Panetta, Timothy E. Peterson, Laurel S. Kleppe, Cheryl S. Mueske, Gert M. Kostner, George J. Broze, Robert D. Simari
Journal: Blood (2001)
Performance of Graduates of Foreign Medical Schools on the Examinations of the American Board of Internal Medicine
Authors: John A. Meskauskas, John A. Benson, Elizabeth Hopkins
Journal: New England Journal of Medicine (1977)

We investigated the performance of two groups of graduates of foreign medical schools on the 1975 and 1976 certification examinations of the American Board of Internal Medicine. Nearly all their postdoctoral residency training was obtained in the United States. The performance (most of those in this study were born in Asia and Southeast Asia) was much lower than that of graduates of United States medical schools. United States citizens who studied medicine abroad performed no better than alien graduates from foreign medical schools. Approximately half the foreign graduates born in the United States studied in Italy, and 10% in Switzerland, Mexico and Belgium. There were no significant differences in performance associated with the type of postdoctoral training (university, university-affiliated, community or other) undertaken in the United States. A significant inverse relation was observed between the interval from completion of training to first examination and the examination performance.
A Radioimmunoassay for Ovarian Cancer
Authors: John L. Lewis
Journal: New England Journal of Medicine (1983)

AS many women die from ovarian cancer in the United States each year as from all other cancers of the genital tract combined. 1 If for no other reason, any development that raises the hope of improving our ability to diagnose or treat this cancer deserves attention.Because of its histologic complexity, the ovary gives rise to benign and malignant tumors of epithelial, stromal, and germ-cell origin.2 Epithelial tumors (serous, mucinous, endometrioid, clear-cell, and undifferentiated) account for about 90 per cent of ovarian carcinomas. Ovarian cancers spread early. This characteristic, along with the lack of early signs or symptoms, accounts for . . .
Federal Regulation of the Practice of Medicine
Authors: M. M. Clapper
Journal: JAMA (1913)

<h3>To the Editor:</h3> —I have read your comments on the Reilly bill (The Journal, Oct. 25, 1913, p. 1557) to the effect that the Reilly bill is "an impossible proposal," by reason of the fact that in the United States "the regulation of the practice of medicine comes under the police power of the state legislatures and not under that of Congress," and further that "the consideration of any measure by Congress providing for the control of the practice in the states by any federal board is simply a waste of time, as any such measure, even if adopted, would be declared unconstitutional as soon as it came into court." If your views correctly state the powers of Congress, this bill should and will be killed in the committee in charge, notwithstanding the fact that "in every other civilized nation such national control is in effect" and the desirability
What is the point of attempting to make a case for cognitive impenetrability of visual perception?
Authors: Boris Crassini, Jack Broerse, R. H. Day, Christopher J. Best, W. A. Sparrow
Journal: Behavioral and Brain Sciences (1999)

We question the usefulness of Pylyshyn's dichotomy between cognitively penetrable and cognitively impenetrable mechanisms as the basis for his distinction between cognition and early vision. This dichotomy is comparable to others that have been proposed in psychology prompting disputes that by their very nature could not be resolved. This fate is inevitable for Pylyshyn's thesis because of its reliance on internal representations and their interpretation. What is more fruitful in relation to this issue is not a difficult dichotomy, but a different look at perception such as proposed by Gibson (1979).