SEVERE ASTHMATIC DYSPNEA AS THE SOLE PRESENTING SYMPTOM OF GENERALIZED ENDOLYMPHATIC CARCINOMATOSIS
Authors: ALBERT I. MENDELOFF
Journal: Annals of Internal Medicine (1945)

Article1 March 1945SEVERE ASTHMATIC DYSPNEA AS THE SOLE PRESENTING SYMPTOM OF GENERALIZED ENDOLYMPHATIC CARCINOMATOSISREPORT OF TWO CASES WITH AUTOPSY FINDINGS AND REVIEW OF THE PERTINENT LITERATURE*ALBERT I. MENDELOFF, M.D.ALBERT I. MENDELOFF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-3-386 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is common knowledge today that respiratory symptoms are not infrequent manifestations of malignant disease arising elsewhere than in the lungs. Metastases to the lung are of fairly common occurrence in a great variety of carcinomata; these metastases usually occur as nodular, solid, or linear masses, without constant relationship to lymphatics, arterioles, or venules. Less commonly, the neoplastic cells are found almost exclusively within the pulmonary lymphatics, and may in addition permeate the venules or arterioles. This type of "carcinomatous lymphangitis" was first described by Andral,1mentioned again by Virchow,2and more fully elaborated by Troisier.3The frequency with which...Bibliography1. ANDRAL G: Précis de path. Anat., Paris, 1829, ii, 44. Google Scholar2. VIRCHOW R: Gaz. Med., 1855. Quoted by TROISIER.3 Google Scholar3. TROISIER E: Cancer de l'estomac; cancer sécondaire des poumons. Lymphangite pulmonaire généralisée, Bull. Soc. Anat. de Paris, 1873, xlviii, 834. Google Scholar4a. SCHMIDT MB: Ueber Krebszellenembolien in den Lungenarterien, Verhandl. d. deutsch. Naturforsch., Braunschweig., 1897, xv, 11. Google Scholar4b. SCHMIDT MB: Die Verbreitungswege der Karzinome und die Beziehung generalisierter Sarcome zu den leukaemischen Neubildungen, 1903, G. Fischer, Jena. Google Scholar5. GREENSPAN EB: Carcinomatous endarteritis of pulmonary vessels resulting in failure of the right ventricle, Arch. Int. Med., 1934, liv, 625. CrossrefGoogle Scholar6. WU TT: Generalized lymphatic carcinosis ("lymphangitis carcinomatosa") of the lungs, Jr. Path. and Bact., 1936, xliii, 61. CrossrefGoogle Scholar7. POPPI A: La carcinosi polmonare endolinfatica generalizzata (C.E.G.), (Studio clinico, radiologico, anatomo-patologico), Arch. di pat. e clin. med., 1935, xiv, 487. Google Scholar8. GAINES LM: Diagnostic problem of causation of dyspnea; report of case with autopsy, Jr. Am. Med. Assoc., 1935, civ, 632. CrossrefGoogle Scholar9. MONTGOMERY GL: Case of pulmonary artery thrombosis with Ayerza's syndrome, Jr. Path. and Bact., 1935, xli, 221. CrossrefGoogle Scholar10. ASSMAN H: Klinische Roentgendiagnostik der innere Erkrankungen, ed. 3, 1924, F. C. W. Vogel, Leipzig, p. 314. Google Scholar11. Cabot case No. 30032, New England Jr. Med., 1944, ccxxx, 87. Google Scholar12. SCHWARZMANN A: Ueber generalisierte carcinomatöse Lymphangitis der Lungen, Acta Radiol., 1934, xv, 491. Google Scholar13. SCHATTENBERGRYAN HJJF: Lymphangitic carcinomatosis of the lungs; case report with autopsy findings, Ann. Int. Med., 1941, xiv, 1710. Google Scholar14. GIRODE J: Lymphangite cancereuse pleuro-pulmonaire sans cancer du poumon, Arch. gén. de méd., 1889, i, 50. Google Scholar15a. ROUVIÈRE H: Anatomy of the human lymphatic system; translated by M. J. TOBINS, 1938, Edwards Bros., Ann Arbor, p. 103. Google Scholar15b. Ibidem, p. 99. Google Scholar16. DRINKERYOFFEY CKJM: Lymphatics, lymph, and lymphoid tissue, 1941, Harvard University Press, Cambridge, p. 85. Google Scholar17. MCNEER G: Cancer of the stomach in the young, Am. Jr. Roentgenol., 1941, xlv, 537. Google Scholar18. MISCALLROVENSTINE LEA: Physiological considerations in the surgical treatment of bronchial asthma, Surgery, 1943, xiii, 495. Google Scholar19. CROMERYOUNGIVY SPRAAC: On the existence of afferent respiratory impulses mediated by the stellate ganglion, Am. Jr. Physiol., 1933, civ, 468. CrossrefGoogle Scholar20. CROMERIVY SPAC: Respiratory death from central vagus stimulation after removal of the stellate ganglia, Am. Jr. Physiol., 1933, civ, 457. CrossrefGoogle Scholar21. BARACH AL: Repeated bronchial relaxation in the treatment of intractable asthma, Jr. Allergy, 1943, xiv, 296. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication May 15, 1944.From the Medical Clinic of the Peter Bent Brigham Hospital and the Department of Medicine, Harvard Medical School. 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SWEIGERT, EDWARD F. MCLAUGHLIN, ERLE M. HEATH 1 March 1945Volume 22, Issue 3Page: 386-397KeywordsArteriolesCarcinomatosisCellsDyspneaHospital medicineLungsLymphangitisPulmonary diseasesVenules Issue Published: 1 March 1945 PDF DownloadLoading ...