tbuckley/cabot-search huggingface dataset:
Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and fas-antibody-induced liver injury
Authors: Judy A. Lawson, Michael A. Fisher, Carol A. Simmons, Anwar Farhood, Hartmut Jaeschke
Journal: Hepatology (1998)

Endotoxin (ET) induces neutrophil sequestration in hepatic sinusoids, the activation of proinflammatory transcription factors (nuclear factor KB [NF-kappaB]) with up-regulation of adhesion molecules on sinusoidal endothelial cells and hepatocytes. However, if galactosamine (Gal) is co-administered with ET, neutrophils transmigrate and attack parenchymal cells. This suggests that a signal from parenchymal cells triggers neutrophil transmigration. In this study, we tested the hypothesis that parenchymal cell apoptosis may induce neutrophil transendothelial migration in the Gal/ET model. Treatment of C3Heb/FeJ mice with 700 mg/kg Gal and 100 microg/kg ET induced tumor necrosis factor alpha (TNF-alpha) formation (13.25 +/- 0.75 ng/mL) and hepatic NF-kappaB activation at 90 minutes; the generation of the C-X-C chemokine KC (2.86 +/- 0.30 ng/mL at 5 hours); sinusoidal neutrophil sequestration (380 +/- 21 polymorphonuclear leukocytes/50 high-power fields) and apoptosis (925% +/- 29% increase of DNA fragmentation; and a 45-fold increase of terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-positive cells) at 6 hours, followed by transmigration of neutrophils and development of substantial necrosis (38% +/- 3% of hepatocytes; alanine transaminase [ALT]: 1,500 +/- 300 U/L) at 7 hours. Administration of uridine (1,000 mg/kg) did not reduce plasma levels of TNF-alpha and KC, NF-kappaB activation, or polymorphonuclear leukocyte sequestration, but attenuated apoptosis by 90% to 94%. In these livers, neutrophils did not transmigrate and liver injury was prevented (necrosis: < 5%; ALT: 40 +/- 3 U/L). However, massive apoptosis and liver injury initiated by the anti-Fas antibody, Jo2, did not recruit neutrophils into the liver. We conclude that excessive parenchymal cell apoptosis represents an important signal for transmigration of primed neutrophils sequestered in sinusoids during endotoxemia in vivo. However, apoptosis per se does not cause neutrophil sequestration in the liver vasculature.
Peripheral Vascular Diseases
Authors: J. H Stewart
Journal: Cardiovascular Research (1993)

Journal Article Peripheral Vascular Diseases Get access James H Stewart James H Stewart Jacksonville, Florida, USA Edited by J R Young, R A Graor, J W Olin, J R Bartholomew. (Pp 789; $US 109.) St Louis: C V Mosby, 1991. ISBN 0-8016-6115-3. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 5, May 1993, Pages 891–892, https://doi.org/10.1093/cvr/27.5.891a Published: 01 May 1993
CARDIOVASCULAR MORTALITY IN PATIENTS WITH TYPE 2 DIABETES AND RECENT ACUTE CORONARY SYNDROMES FROM THE EXAMINE TRIAL
Authors: William B. White, Stuart Kupfer, Steven Nissen, William Cushman, George Bakris, Simon Heller, Richard Bergenstal, Venu Menon, Alfonso Perez, Penny Fleck, Richard Oh, Cyrus Mehta, Craig A. Wilson, Faiez Zannad, Christopher Cannon
Journal: Journal of the American College of Cardiology (2014)
Quis Custodiet ipsos Custodes?
Authors: Marie J. Mergler
Journal: JAMA (1895)

Chicago, April 13,1895. <h3>To the Editor:</h3> —At a meeting of the faculty of the Northwestern University Woman's Medical School, the following resolutions were unanimously adopted and ordered to be placed before the Illinois State Board of Health: Whereas, On three occasions within the past three years, the Illinois State Board of Health has licensed to practice medicine in this State, students who have not properly qualified themselves for such duties, and whose incompetence has compelled us to withhold the degree of Doctor of Medicine; and Whereas, By common report we are informed that the State Board has adopted a similar policy with reference to numerous other persons; therefore, <i>Resolved</i>, By the faculty of the Northwestern University Woman's Medical School that the State Board be requested hereafter to make its examinations so rigid that persons incompetent to obtain the degree of Doctor of Medicine from first class medical colleges can not
Alterations in cyst fluid genetics following endoscopic ultrasound-guided pancreatic cyst ablation with ethanol and paclitaxel
Authors: John DeWitt, Mohamad Al-Haddad, Stuart Sherman, Julia LeBlanc, Christian Schmidt, Kumar Sandrasegaran, Sydney Finkelstein
Journal: Endoscopy (2014)

<b>Background and study aims:</b> Endoscopic ultrasound (EUS)-guided ethanol lavage with paclitaxel injection has been shown to be effective for the treatment of pancreatic cystic neoplasms; however, the evidence for effectiveness is based primarily on cyst resolution on imaging. The aim of this study was to evaluate changes in pancreatic cyst fluid DNA following EUS-guided pancreatic cyst ablation (PCA) with ethanol and paclitaxel. <b>Patients and methods:</b> In a single-center, prospective study, patients with suspected benign pancreatic cysts (15 – 50 mm in diameter; ≤ 5 compartments) underwent EUS-PCA with ethanol and paclitaxel followed 3 months later by repeat EUS-FNA, cyst aspiration for repeat DNA analysis, and possible repeat EUS-PCA. Abdominal imaging was repeated 3 – 4 months and 12 months after the second EUS. Changes in baseline pancreatic cyst fluid DNA, procedural complications, and radiographic changes in cyst volume were evaluated. <b>Results:</b> A total of 22 patients (median age 67 years; 15 women) with cysts in the head or uncinate (n = 10), body or neck (n = 8), and tail (n = 4), measuring a median diameter of 25 mm (range 15 – 43 mm), underwent one (n = 22) or two (n = 9) EUS-PCA procedures. Baseline cyst DNA included mutations in 11 patients (50 %). Postablation cyst fluid (n = 19) showed elimination of all baseline mutations in eight patients, new mutations in three, and no changes in eight without a baseline mutation. The largest per-protocol postablation image-defined volume change (n = 20) from either of the follow-up abdominal imaging studies (n = 20) demonstrated complete response ( < 5 % original volume) in 10 patients (50 %), partial response (5 % – 25 % original volume) in 5 (25 %), and a persistent cyst (> 25 % original volume) in 5 (25 %). During a median follow-up of 27 months (range 17 – 42 months), adverse events from all EUS-PCAs (n = 31) included abdominal pain alone in four patients (13 %), pancreatitis in three (10 %), peritonitis in one (3 %), and gastric wall cyst in one (3 %). The adverse events were classified as moderately severe in four patients (three with pancreatitis, one with peritonitis). <b>Conclusion:</b> EUS-PCA with ethanol and paclitaxel may possibly eliminate mutant DNA in neoplastic pancreatic cysts. This technique leads to complete or partial image-defined resolution in 75 % of cysts but may lead to rare adverse events. Clinical trial registration: ClinicalTrials.gov (NCT01643460)
Abstract 2552: Synergistic antitumor effects of FGFR2 inhibitor with 5-fluorouracil on diffuse-type gastric carcinoma
Authors: Masakazu Yashiro, Osamu Shinto, Kazunori Nakamura, Masashige Tendo, Tasuku Matsuoka, Taro Matsuzaki, Ryoji Kaizaki, Atsushi Miwa, Kosei Hirakawa
Journal: Cancer Research (2011)

Abstract Purpose: Diffuse-type gastric carcinoma carries the highest mortality because of a frequent metastasis to lymph node. S1, a 5-fluorouracil (5-FU) analog, is clinically available for gastric cancer at advanced stage. Fibroblast growth factor receptor 2 (FGFR2) is required for the proliferation of diffuse-type gastric carcinoma. The objective of this study is to clarify the benefit of a combination of S1 and kinase inhibitors including FGFR2 inhibitor Ki23057 in gastric cancer. Experimental Design: OCUM-2MLN and KATO-III were derived from diffuse-type gastric carcinoma. MKN-7 and MKN-74 were derived from intestinal-type gastric carcinoma. MTT assay was used to examine the growth-inhibitory activity of 5 small-synthetic molecules including Ki23057, Sunitinib, Glivec, Lapatinib, or SU11274, in cells cultured with 5-FU. Combination effects of 5-FU with Ki23057 on proliferation, apoptosis, and mRNA expression were examined. S1 and/or Ki23057 were administered to murine models of diffuse-type gastric carcinoma created by the orthotopic inoculation of OCUM-2MLN cells. Results: Ki23057 at 100 nM significantly (p&amp;lt;0.01) inhibited the proliferation, and decreased the phosphorylation of FGFR2 in diffuse-type gastric carcinoma cells, but not in intestinal-type gastric carcinoma. Ki23057 showed synergistic anti-tumor effects for diffuse-type gastric carcinoma cells in combination with 5-FU using CalcuSyn analysis, but Sunitinib, Glivec, Lapatinib, and SU11274 did not. The combination of Ki23057 and 5-FU decreased DPD expression, and increased apoptosis rates, and p21 expression level of diffuse-type gastric carcinoma cells. The combined administration of S1 and Ki23057 significantly (p&amp;lt;0.05) decreased orthotopic tumors as well as lymph node metastasis more effectively than S1 alone. Conclusion: The combined treatment with 5-FU and Ki23057 produced synergistic anti-tumor effects, and is a therapeutically promising for diffuse-type gastric carcinoma treatment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2552. doi:10.1158/1538-7445.AM2011-2552
Parliament debates bill to compensate torture survivors
Authors: Peter Moszynski
Journal: BMJ (2008)

Several thousand people living in the United Kingdom who have been tortured face enormous challenges as a result of their ordeals, say expert submissions to parliament in the current debate on the Torture (Damages) Bill. The bill would enable victims of torture to seek justice in English courts if no other remedy were available to them.

Redress, a charity that seeks reparation for survivors of torture, says that people who have been tortured usually need extensive medical treatment and social support for their physical and psychological injuries, which can last the rest of their lives. These injuries often leave them unable to work and dependent on …
HYDROGEN ION CONCENTRATION IN THERAPEUTIC BASES.
Authors: RALPH G. HARRY
Journal: British Journal of Dermatology (1942)

Journal Article HYDROGEN ION CONCENTRATION IN THERAPEUTIC BASES. Get access RALPH G. HARRY, F.I.C. RALPH G. HARRY, F.I.C. Certificate of the Institute of Chemistry in Foods, Drugs, Pharmaeology and Therapeutics Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 54, Issue 1, 1 January 1942, Pages 1–22, https://doi.org/10.1111/j.1365-2133.1942.tb15786.x Published: 01 January 1942
Acute Bronchiolitis in Children
Authors: D. Hubble, G. R. Osborn
Journal: BMJ (1941)

Capillary bronchitis may well be termed the essential lesion of influenza."-HoRDER.Capillary bronchitis, or, as it is better called, acute bron- chiolitis, is not generally admitted to be a clinical or pAthological entity.The pathologists, the paediatricians, add the writers on diseases of the chest for the most part ddny it *a separate existence.The general view is ex- pressed by Norris and Landis (1938): " The latter term [i.e., capillary bronchiti's] should never be used.While a lesionliimited to' the finer bronchioles is possible theoreti- cally, practically it never exists alone, as an inflammatory process invading the swollen bronchi inevitably extends to the anatomically related and contiguous vesicles as-well.
Controlled trial of Duogastrone in duodenal ulcer.
Authors: W A Davies, P I Reed
Journal: Gut (1977)

A double-blind placebo-controlled trial of carbenoxolone, as 50 mg Duogastrone capsules, and in a dose of 200 mg daily for 12 weeks, was carried out in 40 ambulant subjects with endoscopically diganosed duodenal ulceration, of whom 34 were available for final analysis. Each patient was seen every two weeks and endoscoped at four, eight and 12 weeks. Serum carbenoxolone was measured at each visit. Complete ulcer healing occurred in a significantly greater number of patients receiving Duogastrone than placebo, the significance being greater after four and eight weeks treatment (P less than 0-01) than at 12 weeks (P less than 0-02). While significant symptomatic improvement also was achieved (P less than 0-05), but only after 12 weeks on Duogastrone, there was much closer correlation between ulcer healing and symptom relief, 69% on Duogastrone returning to normal, compared with 22% of controls (P less than 0-02). Rise of systolic blood pressure and reduction in serum potassium levels, especially during the last four treatment weeks, were the most common effects noted in patients taking Duogastrone, and five patients required thiazide diuretics and potassium supplements. Higher serum carbenoxolone levels were found in patients with healed ulcers as well as in those with more marked side-effects.
Poor Cancer Survival Among American Indians
Authors: James C. Hebert
Journal: JAMA Surgery (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
MYOMECTOMY DURING THE SIXTH MONTH OF PREGNANCY. RECOVERY.
Authors: EUGENE R. LEWIS
Journal: JAMA (1900)

As a member of the committee on the progress of surgery in the Missouri State Medical Society, I have asked the chairman to allow me to present this paper, which contains the report of a successful myomectomy made during the sixth month of gestation. No successful case of the kind is on record, so far as my knowledge goes, and I have been diligent in my efforts to find one recorded. Since the books at my command did not contain the information I desired on this subject, I addressed letters to a number of the prominent surgeons and physicians of our state and country. I quote from the letters of Prof. Howard A. Kelly, of Johns Hopkins University, Prof. Nicholas Senn, of Rush Medical College, and Prof. E. E. Montgomery, of Jefferson Medical College. Professor Kelly says: "I know of no case of intramural fibroid, i. e., one with a
A NOTE ON THE DEPIGMENTARY PROPERTIES OF MONOBENZYLETHER OF HYDROQUINONE
Authors: L. FORMAN
Journal: British Journal of Dermatology (1953)

Journal Article A NOTE ON THE DEPIGMENTARY PROPERTIES OF MONOBENZYLETHER OF HYDROQUINONE Get access L. FORMAN L. FORMAN Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 65, Issue 11, 1 November 1953, Pages 406–409, https://doi.org/10.1111/j.1365-2133.1953.tb13174.x Published: 01 November 1953
Enhanced capacity for release of leucotriene B4 by neutrophils in rheumatoid arthritis.
Authors: J Elmgreen, O H Nielsen, I Ahnfelt-Ronne
Journal: Annals of the Rheumatic Diseases (1987)

The calcium dependent metabolism of endogenous arachidonic acid (AA) was investigated in 17 patients with rheumatoid arthritis during treatment with dextropropoxyphene alone and in 25 healthy volunteers. Incorporation of [1-14C]AA into intracellular phospholipids of purified neutrophils was achieved by incubation until steady state before activation with ionophore A23187. Analysis of extracellular metabolites was performed by extraction, thin layer chromatography, autoradiography, and laser densitometry. The patients showed a twofold increase in the total capacity for oxidation of AA. Release of leucotriene B4 (LTB4) and its omega oxidation products, 20-OH LTB4 and 20-COOH LTB4, was 29%, range 11-48%, in patients compared with 8%, range 4-12%, in healthy volunteers. Total amounts of radioactivity released and the specific activity of LTB4, as assessed by high pressure liquid chromatography, were equal in experimental and control groups. The demonstrated increased capacity for metabolism of AA to the major proinflammatory metabolite, LTB4, via the 5-lipoxygenase pathway may contribute to perpetuation of inflammation and to tissue destruction in rheumatoid arthritis.
Endothelial LSP1 is involved in endothelial dome formation, minimizing vascular permeability changes during neutrophil transmigration in vivo
Authors: Björn Petri, Jaswinder Kaur, Elizabeth M. Long, Hang Li, Sean A. Parsons, Stefan Butz, Mia Phillipson, Dietmar Vestweber, Kamala D. Patel, Stephen M. Robbins, Paul Kubes
Journal: Blood (2010)
Prevalence of common and dysplastic naevi in a Swedish population
Authors: A. AUGUSTSSON, U. STIERNER, M. SUURKULA, I. ROSDAHL
Journal: British Journal of Dermatology (1991)

Journal Article Prevalence of common and dysplastic naevi in a Swedish population Get access A. AUGUSTSSON, A. AUGUSTSSON Departments of Dermatology, Sahlgrenska Hospital, Gothenburg, Sweden Dr A. Augustsson, Department of Dermatology. Sahlgrenska Hospital, S‐41345 Gothenburg, Sweden. Search for other works by this author on: Oxford Academic Google Scholar U. STIERNER, U. STIERNER Departments of Oncology, Sahlgrenska Hospital, Gothenburg, Sweden Search for other works by this author on: Oxford Academic Google Scholar M. SUURKÜLA, M. SUURKÜLA Departments of Dermatology, Sahlgrenska Hospital, Gothenburg, Sweden Search for other works by this author on: Oxford Academic Google Scholar I. ROSDAHL I. ROSDAHL Departments of Dermatology, Sahlgrenska Hospital, Gothenburg, Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 124, Issue 2, 1 February 1991, Pages 152–156, https://doi.org/10.1111/j.1365-2133.1991.tb00424.x Published: 01 February 1991
Patient-Safety-Related Hospital Deaths in England: Thematic Analysis of Incidents Reported to a National Database, 2010–2012
Authors: Liam J. Donaldson, Sukhmeet S. Panesar, Ara Darzi
Journal: PLoS Medicine (2014)

Sukhmeet Panesar and colleagues classified reports of patient-safety-related hospital deaths in England to identify patterns of cases where improvements might be possible. Please see later in the article for the Editors' Summary
Abstract 3432: HLJ1 serves as an inhibitor of epithelial-mesenchymal transition by inactivating β-catenin signaling
Authors: Ching-Hsien Chen, Sheng-Yi Lin, Hsuan-Yu Chen, Kang-Yi Su, Ang Yuan, Huei-Wen Chen, Sung-Liang Yu, Jeremy Chen
Journal: Cancer Research (2012)

Abstract HLJ1 (DnaJ-like heat shock protein), also known as DNAJB4, was classified as a tumor suppressor gene. The expression of HLJ1 inversely associates with invasive ability and can predict the clinical outcomes of non-small-cell lung cancer (NSCLC) patients. However, the role of HLJ1 in suppressing cancer metastasis is still unclear. Here, we identified HLJ1 as a novel inhibitor of epithelial-mesenchymal transition (EMT). Our functional assays in vitro and in vivo demonstrated that Knock-down of HLJ1 promotes invasion capabilities of lung cancer cells and causes liver macrometastasis; meanwhile, the crucial domain of HLJ1 in suppression of cancer invasion was also confirmed. We found that the HLJ1-overexpressing cells maintain the well-organized cell adhesion and polarity. Inversely, an increase in actin polymerization and the formation of actin stress fibers were observed in the HLJ1-silencing cells. HLJ1 down-regulates the transcriptional activities of slug promoter and facilitates E-cadherin transcription, leading to the inhibition of epithelial to mesenchymal transition. Further, we identified the Wnt/β-catenin signalling pathway in which HLJ1 involved by cDNA microarray and pathway analysis. The subcellular distribution of β-catenin is predominant in the nucleus and the tyrosine-phosphorylated levels of β-catenin are up-regulated in the HLJ1-silenced clones. Finally, we showed a decreased accumulation of β-catenin and an enhanced degradation of β-catenin in absence of HLJ1 expression. Taken together, our study reveals that HLJ1 has anti-metastatic activity by repressing β-catenin signaling and provides a molecular model for the development of new anticancer agents. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3432. doi:1538-7445.AM2012-3432
Cell-Permeable NM23 Blocks the Maintenance and Progression of Established Pulmonary Metastasis
Authors: Junghee Lim, Giyong Jang, Seeun Kang, Guewha Lee, Do Thi Thuy Nga, Do Thi Lan Phuong, Hyuncheol Kim, Wael El-Rifai, H. Earl Ruley, Daewoong Jo
Journal: Cancer Research (2011)

Occult metastases are a major cause of cancer mortality, even among patients undergoing curative resection. Therefore, practical strategies to target the growth and persistence of already established metastases would provide an important advance in cancer treatment. Here, we assessed the potential of protein therapy using a cell permeable NM23-H1 metastasis suppressor protein. Hydrophobic transduction domains developed from a screen of 1,500 signaling peptide sequences enhanced the uptake of the NM23 protein by cultured cells and systemic delivery to animal tissues. The cell-permeable (CP)-NM23 inhibited metastasis-associated phenotypes in tumor cell lines, blocked the establishment of lung metastases, and cleared already established pulmonary metastases, significantly prolonging the survival of tumor-bearing animals. Therefore, these results establish the potential use of cell-permeable metastasis suppressors as adjuvant therapy against disseminated cancers.
Asbestos poisoning was covered up by doctors, claims health team
Authors: G. Mudur
Journal: BMJ (2003)

Doctors in India are under pressure to label patients with asbestos poisoning as having tuberculosis or bronchitis and to underplay the health impact of asbestos, a public health team has said.

Many thousands of people in India suffer from lung diseases caused by exposure to asbestos, occupational health specialists said at a press conference last week, reiterating their demand for a ban on asbestos.

India uses around 125 000 tonnes of asbestos each year, which it imports mostly from Canada and Russia. Nearly all (90%) …
HIV Infections Decline in Africa
Authors: Joan Stephenson
Journal: JAMA (2010)

New HIV infections in sub-Saharan Africa, the region most affected by HIV/AIDS, have declined substantially in the past decade, the United Nation's Program on HIV/AIDS (UNAIDS) reported last month in a statement (http://data.unaids.org/pub/PressRelease/2010/20100917_pr_mdgsummit_en.pdf).