tbuckley/cabot-search huggingface dataset:
Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity
Authors: Christopher E Andoniou, Serani L H van Dommelen, Valentina Voigt, Daniel M Andrews, Geraldine Brizard, Carine Asselin-Paturel, Thomas Delale, Katryn J Stacey, Giorgio Trinchieri, Mariapia A Degli-Esposti
Journal: Nature Immunology (2005)
Abstract P3-10-15: Quantitative Gene Expression by RT-PCR in Classic and Variant Forms of Lobular Carcinoma in Estrogen Receptor Positive Invasive Breast Cancer
Authors: JM Anderson, C Yoshizawa, EP Winer, D Watson, C Millward, V Tan, S Shak, FL Baehner
Journal: Cancer Research (2010)

Abstract Background: Classic lobular carcinoma is characterized by a distinctive morphology, loss of E-cadherin commonly due to mutation or deletion of CDH1 on chromosome 16q, and a variable clinical course (Pestalozzi J Clin Oncol. 2008 26:3006). Variants (pleomorphic, solid and alveolar) with distinct morphologies and potential differences in outcome have been described (Rosen 2009). Herein we explore the patterns of quantitative gene expression as measured by the 21 gene Oncotype DX® assay observed between ductal NOS (DC) and classic and variant lobular carcinomas. Material and Methods: All tumors analyzed in the Genomic Health laboratory from 6/1/04-3/31/10 were included. Central path used WHO criteria for classification of classic lobular (CL), solid &amp; alveolar lobular (SAL), and pleomorphic lobular (PL) carcinomas. Quantitative expression of 16 cancer related genes was measured on a scale from 0 to 15 (relative to reference genes) where a 1 unit increment is associated with an ∼2-fold change in expression. Descriptive statistics for RS &amp; individual genes [ER, PR, invasion gene group (IGG) &amp; proliferation gene group (PGG)] among the different subtypes were obtained. Comparisons of means among the subtypes were adjusted to control the overall error rate under any complete or partial null hypothesis. Results: DC accounted for 90.4% of 133,234 cases, CL 8.2%, SAL 0.7% and PL 0.8%. For all types a continuous range of RS was observed. DC had the greatest percentage of high risk RS followed by SAL, PL and CL. DC had the highest RS and CL had the lowest RS. SAL had the highest ER expression and CL had the lowest expression, but these results may refect a submission bias and are not population based. The proportion with the ER+/PR-phenotype was slightly different among the subtypes: SAL (24.2%) and PL (19.5%) had a higher incidence compared to DC (15%) and CL (15.6%). SAL had the highest PGG expression; CL had the lowest. DC had the highest IGG; CL had the lowest. Discussion: Classic lobular carcinoma and the lobular carcinoma variants are characterized by differential patterns of gene expression. Outlier cases are not infrequent within each of the special subtypes in this large observational cohort. The variation in gene expression, noted by histologic subtype, will be presented in detail. RS Distributions in Ductal NOS, Lobular and Lobular Variants Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P3-10-15.
Modulation of L-type calcium current by internal potassium in guinea pig ventricular myocytes
Authors: Klaus W. Linz, Rainer Meyer
Journal: Cardiovascular Research (1997)

The early phase of myocardial ischemia is characterized by a considerable K+ efflux from cardiac myocytes, causing decreasing internal ([K+]i) and increasing external ([K+]o) K+ concentrations. The change in [K+]i and [K+]o is one of the factors thought to initiate the ischemia-induced changes in electrical activity. Nevertheless, little is known about the influence of [K+]i and [K+]o on the L-type calcium current.The whole-cell patch-clamp technique combined with an internal perfusion system was used to test possible actions of altered [K+]i and [K+]o on L-type current carried by Ca2+ and Ba2+ in isolated guinea pig ventricular myocytes.Changing the [K+]i in the range of 110-170 mM revealed a sigmoidal concentration-response relationship between the L-type current and [K+]i. The maximum change in current amplitude was more than 40% with a half-saturation concentration of 136 mM which is near the physiological [K+]i. Ca2+ influx during action potential clamp increased by approximately 42% after raising [K+]i from 130 to 170 mM. Internal perfusion with Cs+ demonstrated that Cs+ is less effective than K+ in regulating the L-type current. By using ATP-analogues, [K+]i was shown to affect the L-type channel in a phosphorylation-independent way. Changes in [K+]o only modulated the L-type current via alterations in [K+]i.The decrease in [K+]i during early ischemia is, per se, sufficient to reduce the L-type current by up to 15%, thereby decreasing the action potential duration, and Ca2+ influx into the cells. This may act in addition to well-known mechanisms such as changes in internal pH and falling ATP levels, which influence the L-type current. Moreover, the phenomenon may complicate the interpretation of electrophysiological measurements of L-type current under conditions where [K+]i is not precisely controlled.
Molecular profiling of CD3−CD4+ T cells from patients with the lymphocytic variant of hypereosinophilic syndrome reveals targeting of growth control pathways
Authors: Marie Ravoet, Catherine Sibille, Chunyan Gu, Myriam Libin, Benjamin Haibe-Kains, Christos Sotiriou, Michel Goldman, Florence Roufosse, Karen Willard-Gallo
Journal: Blood (2009)
Diagnosis and Treatment of Malignant Carcinoid Syndrome
Authors: Alvin L. Ureles
Journal: JAMA (1974)

THE malignant carcinoid syndrome has challenged the skills of the clinician, biochemist, and pharmacologist since its original description by Biorck et al 1 22 years ago.  Although attention originally centered on a symptom complex and a serotonin-producing midintestinal neoplasm that had metastasized to the liver, the carcinoid syndrome has now been expanded to include a spectrum of biochemical, anatomic, and histologic variants. These embrace such diverse sites as stomach, rectum, bronchus, ovary, pancreas, biliary tract, and Meckel diverticulum, and are expressed biochemically by the tryptophan-serotonin pathway, histamine, the kinin-kallikrien system, and probably other vasoactive amines. 2 The malignant carcinoid syndrome has been associated with tumor production of immunoreactive insulin, secondary hypoglycemia, Cushing syndrome via corticotropin, and hyperpigmentation via melanotropin secretion. 3   In addition, the malignant carcinoid syndrome may present as a paraneoplastic syndrome of such noncarcinoid malignant neoplasms as oat cell cancer of the lung, medullary cancer of the thyroid,
Perioperative fluvastatin reduced cardiac events after noncardiac vascular surgery
Authors: Naeem Al-Shoaibi
Journal: Annals of Internal Medicine (2010)

ACP Journal Club19 January 2010Perioperative fluvastatin reduced cardiac events after noncardiac vascular surgeryNaeem Al-Shoaibi, MD, David Massel, MDNaeem Al-Shoaibi, MDLondon Health Sciences Centre, London, Ontario, Canada (N.A., D.M.)Search for more papers by this author, David Massel, MDLondon Health Sciences Centre, London, Ontario, Canada (N.A., D.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-2-201001190-02007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationSchouten O, Boersma E, Hoeks SE, et al. Fluvastatin and perioperative events in patients undergoing vascular surgery. N Engl J Med. 2009;361:980-9. https://pubmed.ncbi.nlm.nih.gov/19726772Clinical Impact RatingsCardiology: References1 Genest J, McPherson R, Frohlich J, et al. 2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult—2009 recommendations. Can J Cardiol. 2009;25:567-79. [PMID: 19812802] Google Scholar2 Aung PP, Maxwell HG, Jepson RG, Price JF, Leng GC. Lipid-lowering for peripheral arterial disease of the lower limb. Cochrane Database Syst Rev. 2007;(4):CD000123. [PMID: 17943736] Google Scholar3 Dunkelgrun M, Boersma E, Schouten O, et al. Bisoprolol and fluvastatin for the reduction of perioperative cardiac mortality and myocardial infarction in intermediate-risk patients undergoing noncardiovascular surgery: a randomized controlled trial (DECREASE-IV). Ann Surg. 2009;249:921-6. [PMID: 19474688] Google Scholar Author, Article, and Disclosure InformationAffiliations: London Health Sciences Centre, London, Ontario, Canada (N.A., D.M.)This article was published at Annals.org on 5 January 2010. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 19 January 2010Volume 152, Issue 2Page: JC1-7KeywordsCardiac surgeryIschemiaMyocardial infarctionStable coronary artery diseaseStatinsSurgeryTransient ischemic attacksVascular surgery ePublished: 19 January 2010 Issue Published: 19 January 2010 CopyrightCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Surgical Pediatric Urology
Authors: Lowell R. King
Journal: JAMA (1978)

The great strength and unique feature of this volume is the excellence of the illustrations, which cover a wide range of operative techniques. This comment is not meant to disparage the text, which is generally clear, concise, and to the point. The editors point out that the level of sophistication in pediatric urology is increasing rapidly, as is the complexity of some surgical procedures. Yet in many instances patient management must be carried out by a general urologist, surgeon, or pediatric surgeon without special training in pediatric urology. This volume suggests the current operation suitable in a great variety of clinical situations and delineates the surgical technique in such detail that it should enable surgeons experienced in urology to perform at least some complex pediatric urologic procedures with élan.<i>Surgical Pediatric Urology</i>also serves as an excellent atlas and compendium of current surgical techniques for the practicing pediatric urologist. The
Unraveling the complexity of tyrosine kinase inhibitor–resistant populations by ultra-deep sequencing of the BCR-ABL kinase domain
Authors: Simona Soverini, Caterina De Benedittis, K. Machova Polakova, Adela Brouckova, David Horner, Michele Iacono, Fausto Castagnetti, Gabriele Gugliotta, Francesca Palandri, Cristina Papayannidis, Ilaria Iacobucci, Claudia Venturi, Maria Teresa Bochicchio, Hana Klamova, Federica Cattina, Domenico Russo, Paola Bresciani, Gianni Binotto, Barbara Giannini, Alexander Kohlmann, Torsten Haferlach, Andreas Roller, Gianantonio Rosti, Michele Cavo, Michele Baccarani, Giovanni Martinelli
Journal: Blood (2013)
Abstract 1503: PSMA Aptamer-targeted siRNAs selectively Eehance prostate cancer radiation sensitivity
Authors: Xiaohua Ni, Yonggang Zhang, Judit Ribas, Theodore L. DeWeese, Shawn E. Lupold
Journal: Cancer Research (2010)

Abstract The application of dose escalated radiation therapy for localized prostate cancer has a clear therapeutic benefit; however, its clinical use is hampered by the increased risk of damage to surrounding normal tissues. One attractive alternative to elevated doses is radiation sensitizing agents. Prostate cancer cells can be made radiosensitive by targeted reductions of DNA repair proteins via RNA interference. However, without tissue-selective targeting, these agents will also sensitize surrounding tissue, leading to increased adverse effects. Here we describe a strategy where prostate-targeted RNA interference is used to selectively radio-sensitize prostate cancer cells. A high throughput siRNA screen was completed to identify DNA-repair pathway targets for prostate cancer radio-sensitization. Candidate siRNAs were then conjugated to PSMA-targeted RNA aptamers for selective delivery of siRNAs to Prostate cancer cells. In vitro and in vivo data support PSMA and aptamer-specific targeting and gene knock-down. These studies support continued development of this technology as a path to enhance radiotherapeutic outcomes for men with Prostate cancer and it is the first report of targeted, prostate-specific siRNAs for radio-sensitization. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1503.
Audit Scotland calls for more evidence of effective care for long term illness
Authors: Bryan Christie
Journal: BMJ (2007)

Decisions on managing long term medical conditions in Scotland are being made on limited evidence of what works for patients, says a report from the public service watchdog, Audit Scotland.

The report calls for better information to be provided urgently on the cost, quality, and scope of such services to ensure the best use of resources and the most appropriate service provision in the future.

The report says that managing long term conditions is one of the biggest challenges facing healthcare systems worldwide. In the United Kingdom these conditions account …
PARTICULATE MATTER-INDUCED PROCOAGULANT MICROPARTICLE GENERATION BY HUMAN MONONUCLEAR CELLS: A POSSIBLE NOVEL LINK BETWEEN AIRBORNE POLLUTANTS AND CARDIOVASCULAR DISEASES
Authors: Tommaso Neri, Silvia Petrini, Federica Rota, Cristina Balia, Valentina Scalise, Roberto Pedrinelli, Pierluigi Paggiaro, Valentina Bollati, Alessandro Celi
Journal: Journal of the American College of Cardiology (2015)
Seminars in Infectious Disease
Authors: Anad P. Panwalker
Journal: JAMA (1980)

This offering is the second volume of what is planned to be an annual series of review articles. Its aim is to recognize "the need for yearly review of old and recently acquired knowledge in the area of infectious diseases" and "to provide a forum useful to all physicians interested in the art and science of infectious diseases." A distinguished group of clinicians and investigators has assembled ten review articles that include Hirschman's masterpiece on viral hepatitis, Ratzan's scholarly analysis of the role of surface factors in the pathogenesis of infection, and the well-written discussion on mechanisms in the production of fever. Equally informative are chapters on nosocomial viral infections, the nutritional determinants of host responses in infection, and diseases caused by human herpesviruses. An outstanding feature of all these articles is the inclusion of current references, some as recent as 1979. The review of newer microbiological methods is well
The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection
Authors: Matthew M. Staron, Simon M. Gray, Heather D. Marshall, Ian A. Parish, Jonathan H. Chen, Curtis J. Perry, Guoliang Cui, Ming O. Li, Susan M. Kaech
Journal: Immunity (2014)
The influence of isosorbide dinitrate on regional myocardial blood flow during acute coronary occlusion in the dog
Authors: G. K. JETT, S. K. DENGLE, M. R. PLATT, R. C. EBERHART, J. T. WILLERSON, J. T. WATSON
Journal: Cardiovascular Research (1978)

We investigated the influence of isosorbide dinitrate (ISDN), alone and combined with methoxamine, on regional myocardial blood flow during acute coronary occlusion. Cardiac output, mean aortic pressure, and heart rate were kept constant in open chest, chloralose anaesthetised dogs so that coronary flow alterations would be relatively independent of haemodynamic effects. Regional myocardial blood flow was measured using 9 μm radioactive microspheres. Mean aortic pressure, left ventricular end diastolic pressure and maximum left ventricular dP/dt were unchanged by ISDN. Studies of ISDN (5mg) treatment before the second of two 10 min consecutive reversible ligations of the left anterior descending coronary artery (LAD) demonstrated: (1) ISDN infused 35 min before LAD ligation increased collateral coronary blood flow to ischaemic myocardium 27± 9% (P <0.05); (2) ISDN + methoxamine infused 35 min before LAD ligation increased collateral coronary blood flow to ischaemic myocardium 8 ± 4% (NS). ISDN(5mg) treatment 20 min after LAD ligation demonstrated: (1) collateral coronary blood flow to ischaemic myocardium increased 11 ± 7% (NS), 23± 5% (P <0.005) and 17± 5% (P <0.02) at 15, 30, and 45 min, respectively, after drug treatment when compared with blood flow measured just before drug treatment and collateral coronary blood flow 60, 75, and 90 min after drug treatment was not significantly different from control. The results suggest that preligation and postligation administration of ISDN significantly increases collateral coronary blood flow to ischaemic myocardium and the effect continues at least 45 min after treatment. In these studies the addition of methoxamine to ISDN did not further increase collateral coronary blood flow and in fact appeared to slightly decrease blood flow when compared with ISDN alone.
Treatment of refractory large granular lymphocytic leukemia with 2-chlorodeoxyadenosine
Authors: Martin J. Edelman, Robert T. O'Donnell, Ivan Meadows
Journal: American Journal of Hematology (1997)

A 50-year-old man with large granular lymphocytic leukemia (CD3+, CD8+) complicated by severe pancytopenia and life-threatening infections refractory to therapy with prednisone, methotrexate, cyclosporine, and G-CSF is described. Treatment with two cycles of 2-chlorodeoxyadenosine (2-CDA) at 0.1 mg/kg by continuous intravenous infusion for 7 days each cycle resulted in resolution of cytopenias and clearance of leukemic cells. T-cell receptor gene rearrangement, initially present, was not detectable after therapy with 2-CDA. The rapid and complete response to 2-CDA after unsuccessful attempts with prior therapy suggests that 2-CDA should be considered for initial treatment of this disorder. Am. J. Hematol. 54:329–331, 1997. © 1997 Wiley-Liss, Inc.
On the Sanitary State of England during the Middle Ages: As Deduced from the Domestic Habits of the People
Authors: J. Russell
Journal: BMJ (1866)

I am indebted for the architeetural data which constitute the substance of the following paper, entirely to the late Mr. Hudson Turner's clissical work oti the Domestic Architecture qf the illiddle Ages, continued, after his death, by the editor of the Glossa-y of Architectture.I have also to ackniowledge information derived fronji a paper by Dr. WV. D. Cookson, in the Transactions of the Lincoln- shire Topographical Society.It will be seen that Dr. Murchison's valuable work onl Continued Fevers has guided me in the application I have made of the facts gained from other sources.
922. Paracrine Alterations of Endothelial Cells Adhesion Complexes; Implications for Stem Cell Homing
Authors: Ion S. Jovin, Jinette D. Abbott, Thomas Manes, Zhenrong Hao, Lei Li, Reed P. Hickey, Yan Huang, Dingang Liu, Martin S. Kluger, Frank J. Giordano
Journal: Molecular Therapy (2005)

The impact of stem cell therapy for patients with myocardial infarction could be significantly augmented by enhancing homing of the stem cells to the injured myocardium.We hypothesized that transcriptional activation of VEGF in cardiac myocytes by either hypoxia inducible factor(HIF)-1 alpha or an engineered zinc finger protein (ZFP) would initiate mechanisms that could enhance stem cell homing.
TESTS FOR VISUAL ACUTENESS; THEIR ILLUMINATION; AND THE STANDARD OF NORMAL VISION.Read in the Section of Ophthalmology at the Forty-first Annual Meeting of the American Medical Association, at Nashville, Tenn., May, 1890.
Authors: EDWARD JACKSON
Journal: JAMA (1891)

The adoption of a definite series of tests for visual acuteness, constitutes an important advance in the diagnosis of ocular conditions. The Jaeger scale and method of notation added greatly to the definiteness of our knowledge. But the work of Snellen brought a further advance, of perhaps equal importance; and his series of test-type, and system of fractional notation have almost entirely supplanted their predecessors. Probably most of us have realized that the Snellen system, too, is not perfect; and whether or not we are prepared to at once supersede it, a discussion of its deficiencies, leading to a more exact appreciation of them, will certainly be profitable. We use tests of visual acuteness for two purposes, the determination of visual power of the eye, and the ascertaining what lens from the trial set best corrects its error of refraction. For the former use we require of our standard that
The reliability and practicality of single crystal echocardiography in the evaluation of single ventricle. Angiographic and pathological correlates.
Authors: R M Bini, K R Bloom, J A Culham, R M Freedom, C M Williams, R D Rowe
Journal: Circulation (1978)

A prospective clinical and echocardiographic diagnosis of single ventricle was made in 42 patients. Each was evaluated for the number of atrioventricular (A/V) valves, presence of an outflow chamber (OC), A/V valve-semilunar continuity, and orientation of the great arteries. Angiographic correlations were subsequently obtained in 40 and autopsies in 12. The overall diagnosis of single ventricle was substantiated in 39. Two other patients diagnosed as single ventricle by angiography were thought to have large ventricular septal defects on echocardiography. Tricuspid valve was interpreted as septum in one. The angiographic diagnosis of single ventricle was incorrect in another, correctly diagnosed by echocardiography and confirmed at pathology. The differential diagnosis also included A-V canal, L-transposition of the great arteries, double outlet right ventricle, and tricuspid atresia. This last condition has to be differentiated on clinical evidence. The echocardiograms were of particular value in determining the number of A/V valves. Two great arteries were demonstrated in 74% of patients and their relationship was correctly determined in 79% of these. Both imaging techniques agreed closely as to A/V valve-semilunar continuity and presence of an OC, but both showed some inaccuracies compared to pathological specimens. The echocardiogram helps both in planning catheterization and in evaluating the overall diagnosis.
No relation between body mass and gastro-oesophageal reflux symptoms in a Swedish population based study
Authors: J Lagergren
Journal: Gut (2000)

<h3>BACKGROUND</h3> There is a widespread notion that obesity leads to gastro-oesophageal reflux but scientific evidence of an association is limited and inconsistent. <h3>AIMS</h3> To estimate the strength of the association between body mass and reflux symptoms, we performed a population based cross sectional interview study. <h3>SUBJECTS</h3> Population based, randomly selected, middle aged or elderly persons in Sweden in 1995–1997. <h3>METHODS</h3> At face-to-face interviews we asked a stratified sample of Swedes about body measures and occurrence of reflux symptoms. Odds ratios (OR) with 95% confidence intervals (CI), calculated by logistic regression with multivariate adjustments for covariates, were the measures of association. <h3>RESULTS</h3> Reflux symptoms occurring at least once a week more than five years before the interview were reported by 135 (16%) of the 820 interviewees. Among those who had ever been overweight during adulthood (body mass index (BMI) ⩾25 kg/m<sup>2</sup>), the OR of having recurrent reflux symptoms was 0.99 (95% CI 0.66–1.47) compared with those who were never overweight. There was no association between BMI at age 20, BMI 20 years before the interview, or maximum adult BMI and occurrence of reflux symptoms: ORs per unit increase in BMI were 1.00 (95% CI 0.93–1.09), 1.03 (95% CI 0.96–1.10), and 1.01 (95% CI=0.95 1.07), respectively. There was no association between BMI and severity or duration of reflux symptoms. <h3>CONCLUSIONS</h3> Gastro-oesophageal reflux symptoms occur independently of body mass index. Weight reduction may not be justifiable as an antireflux therapy.