tbuckley/cabot-search huggingface dataset:
Gradual Disappearance of Human Variation
Authors: P. R. Davis
Journal: BMJ (1967)

<h3>Abstract</h3> Growth differentiation factor 15 (GDF15) is a stress response cytokine that is elevated in several cardiometabolic diseases and has attracted interest as a potential therapeutic target. To further explore the association of GDF15 with human disease, we conducted a broad study into the phenotypic and genetic correlates of GDF15 concentration in up to 14,099 individuals. Assessment of 772 traits across 6,610 participants in FINRISK identified associations of GDF15 concentration with a range of phenotypes including all-cause mortality, cardiometabolic disease, respiratory diseases and psychiatric disorders as well as inflammatory markers. A meta-analysis of genome-wide association studies (GWAS) of GDF15 concentration across 3 different assay platforms (n=14,099) confirmed significant heterogeneity due to a common missense variant rs1058587 in <i>GDF15</i>, potentially due to epitope-binding artefacts. After conditioning on rs1058587, statistical fine-mapping identified 4 independent putative causal signals at the locus. Mendelian randomisation (MR) analysis did not find evidence of a causal relationship between GDF15 concentration and cardiometabolic traits. Using reverse MR, we identified a potential causal association of body mass index on GDF15 (IVW <i>p</i><sub>FDR</sub>=0.0072). Taken together, our data do not support a role for elevated GDF15 concentrations as a causal factor in human cardiometabolic disease but support its role as a biomarker of metabolic stress.
Prevalence and Variability of Internal Mammary Artery Graft Use in Contemporary Multivessel Coronary Artery Bypass Graft Surgery
Authors: Minoru Tabata, Joshua D. Grab, Zain Khalpey, Fred H. Edwards, Sean M. O'Brien, Lawrence H. Cohn, R. Morton Bolman
Journal: Circulation (2009)

Use of an internal mammary artery (IMA) is a well-recognized, nationally endorsed quality indicator for evaluating the process of operative care for coronary artery bypass graft surgery. An objective assessment of the current status of IMA use has not been systematically performed.This cross-sectional observational study analyzed data on 541 368 coronary artery bypass graft surgery procedures reported by 745 hospitals in the Society of Thoracic Surgeons National Cardiac Database from 2002 through 2005. We assessed the current status of IMA use, the association of hospital volume and IMA use, and disparities in IMA use by patient gender and race and by region of hospital location. Rates of using at least 1 IMA and bilateral IMA were 92.4% and 4.0%, with increasing trends over the years. Hospital volume was not significantly associated with IMA use. IMAs were used less frequently in women than men (for at least 1 IMA: odds ratio, 0.62; 95% confidence interval, 0.61 to 0.63; for bilateral IMA: odds ratio, 0.65; 95% confidence interval, 0.63 to 0.68) and less frequently in nonwhite patients than white patients (for at least 1 IMA: odds ratio, 0.84; 95% confidence interval, 0.81 to 0.87; for bilateral IMA: odds ratio, 0.79; 95% confidence interval, 0.75 to 0.83). There were significant differences in frequency of IMA use by hospital region.Frequency of IMA use in coronary artery bypass graft surgery is increasing; however, many patients still do not receive the benefits of IMA grafts, and some hospitals have a very low IMA use rate. Hospital volume is not associated with IMA use in coronary artery bypass graft surgery. Analysis of this critical performance measure reveals significant gender and race disparities.
Intrapelvic Hemorrhage and Renal Vein Thrombosis
Authors: R. GENIN
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 February 1978Intrapelvic Hemorrhage and Renal Vein ThrombosisR. GENIN, M.D., J. M. CHALOPIN, M.D., G. RIFLE, M.D.R. GENIN, M.D.Search for more papers by this author, J. M. CHALOPIN, M.D.Search for more papers by this author, G. RIFLE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-2-269_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We have read with interest the paper by Appel and associates (1) relating to renal vein thrombosis during systemic lupus erythematosus glomerulonephritis (1). We were particularly interested by the two cases of "laterouterine hematomas" occuring during anticoagulant therapy. We wish to add our experience with a case of intraperitoneal hematoma occuring during anticoagulant therapy for renal vein thrombosis due to extramembranous glomerulonephritis.A 29-year-old white woman was first seen at our hospital in July 1975 with typical symptoms of the nephrotic syndrome. Physical findings were unremarkable except for edema of legs. Arterial blood pressure was 120/80 mm...Reference1. APPELWILLIAMSMELTZERPIRANI GGJC: Renal-vein thrombosis nephrotic syndrome and systemic lupus erythematosus. An association in four cases. Ann Intern Med 85:310-317, 1976 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: R. GENIN, M.D.; J. M. CHALOPIN, M.D.; G. RIFLE, M.D.Affiliations: Nephrology Unit Hôpital du Bocage 21034—Dijon-Cedex France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1978Volume 88, Issue 2Page: 269-269KeywordsAnticoagulant therapyBlood pressureEdemaGlomerulonephritisHemorrhageLupus erythematosusVeins ePublished: 1 December 2008 Issue Published: 1 February 1978 PDF downloadLoading ...
Inhibition of inducible nitric oxide synthase reduces myocardial injury in autoimmune myocarditis rats
Authors: Michiaki Hiroe, Shigeru Ishiyama, Toshio Nishikawa, Hiroe Nakazawa, Hiroshi Ito, Takashi Shimojo, Takeshi Kasajima, Fumiaki Marumo
Journal: Journal of the American College of Cardiology (1996)
Necrobiosis Lipoidica Diabeticorum
Authors: Kim Eagle, Stephen F. Templeton, S. Wright Caughman
Journal: New England Journal of Medicine (1993)

Figure 1. Necrobiosis Lipoidica Diabeticorum. The photograph shows the anterior surface of the lower leg of a 20-year-old woman who had a 10-year history of poorly controlled diabetes mellitus. The lesion measures 9 by 5 cm and has characteristic atrophic, shiny, yellow-brown telangiectatic plaques with ulceration and scarring. Treatment consisted of whirlpool therapy, occlusive dressings, topical steroids, aspirin, and pentoxifylline.
Visualization of a Perforated Small Bowel Duplication During Meckel??s Scintigraphy
Authors: ONUR DEMIRKOL, ISIK ADALET, CEM BONEVAL, SEMA CANTEZ
Journal: Clinical Nuclear Medicine (1995)

A case of a small bowel tubular duplication is described, It was lined with ectopic gastric mucosa which showed a perforation. The diagnosis was made preoperatlvely by TC-99m pertechnetate scintigraphy.
Evaluation of Diseased Coronary Arterial Branches by Polar Representations of Thallium-201 Rotational Myocardial Imaging
Authors: TOMOYA IINO, NOBUO TOYOSAKI, TAKA??AKI KATSUKI, TOSHITAKA NODA, TAKASHI NATSUME, TOSHIO YAGINUMA, SAICHI HOSODA, MAKOTO FURUSE
Journal: Clinical Nuclear Medicine (1987)

The perfusion territories in polar representations of stress T1-201 rotational myocardial imaging in patients with angina pectoris who had one diseased coronary segment were analyzed. The lesions proximal or distal to the first major septal perforator in left anterior descending arteries were detected by the presence or absence of defects at the base of the anterior septum. Right coronary artery lesions were detected by the presence of defects at the basal posterior septum, in contrast to the preservation of myocardial uptake at this portion in lesions of the left circumflex artery. The specific defect patterns were detected in cases with lesions at the first diagonal, obtuse marginal, and posterolateral branches. Recognition of these defects in the polar maps allows detailed detection of diseased coronary arterial branches.
Remitting Seronegative Symmetrical Synovitis With Pitting Edema
Authors: Robert M. Michaels
Journal: JAMA (1986)

To the Editor.—  The article by McCarty et al1described ten elderly patients with an acute-onset seronegative symmetric synovitis associated with pitting  of the hands and feet, which completely remitted over several months. The authors believe that these cases were representative of a distinctive syndrome and chose to call it remitting seronegative symmetrical synovitis with pitting edema (RS3PE syndrome). In their discussion, the authors postulate that an infectious agent might trigger this syndrome in a genetically programmed host. We have recently seen a patient identical to that described by McCarty et al, in whom an infectious agent known to cause a reactive arthritis,Campylobacter jejuni, was isolated by routine stool culture.2  Report of a Case.—  On Feb 4, 1985, a 62-year-old man began experiencing a sore throat, nausea, vomiting, an episode of diarrhea, and fever. On the morning of Feb 10, 1985, he awoke
Acute Rheumatic Fever: Forgotten but Not Gone
Authors: Alan L. Bisno
Journal: New England Journal of Medicine (1987)

The decline in the incidence of acute rheumatic fever in North America and Western Europe since the end of World War II has been truly phenomenal. Indeed, in the past 20 years alone, the annual incidence rate among school-age children in major cities has dropped by more than 90 percent. The great rheumatic fever sanitariums of yesteryear have now closed their doors or been reassigned to other missions, and the admission of a patient with a possible case of acute rheumatic fever to the wards of our teaching hospitals occasions a hurried call for the most senior clinicians to adjudicate . . .
Respiratory Acidosis, Intermittent Ventilation, and Parenteral Nutrition
Authors: MICHAEL CANHAM
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 February 1982Respiratory Acidosis, Intermittent Ventilation, and Parenteral NutritionMICHAEL CANHAM, M.D.MICHAEL CANHAM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-2-254_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The paper by Covelli and colleagues (1) points out an important concern in the critically ill patient with inadequate respiratory function. Also, it identifies another potential problem in the ventilatory management of patients needing total parenteral nutrition: the development of acute respiratory acidosis during intermittent mandatory ventilation. Although the case reports of Patients 1 and 2 did not specifically state that intermittent mandatory ventilation was used, this mode was indicated by the low respiratory rate and low minute ventilation as well as the discussion in the text; it was stated specifically that Patient 3 received intermittent mandatory...References1. COVELLIBLACKOLSENBEEKMAN HJMJ. Respiratory failure precipitated by carbohydrate loads. Ann Intern Med. 1981;95:579-81. LinkGoogle Scholar2. LUCEPIERSONHUDSON JDL. Intermittent mandatory ventilation. Chest. 1981;79:678-85. CrossrefMedlineGoogle Scholar3. DOEKELSWILLICHSCOGGINKRYGERWEIL RCCMJ. Clinical semi-starvation, depression of hypoxic ventilatory response. N Engl J Med. 1976;295:358-61. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Colorado Health Sciences Center Denver, CO 80262 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTotal parenteral nutrition for patients with respiratory insufficiencyComplications of total parenteral nutrition 1 February 1982Volume 96, Issue 2Page: 254-254KeywordsNutritionRespiratory rateTotal parenteral nutrition Issue Published: 1 February 1982 PDF downloadLoading ...
Alun Lloyd Thomas
Authors: H. Thomas
Journal: BMJ (2002)

Former general practitioner Edmonton, Alberta, Canada (b 1908; q Edinburgh 1932), d 14 August 2002.

Alun Lloyd Thomas practised from 1936 to 1940 in New Ferry, Cheshire. He served under the London Missionary Society from 1940 to 1950 at the Nethersole Hospital, Hong Kong, and under the United Church of Canada from 1951 to 1957 at the George McDougall Hospital, Smoky Lake, Alberta, Canada. He was a family doctor in Edmonton, Alberta, from 1957 to 1976. He and his wife spent the first three years of married life in a Japanese internment camp in Hong Kong. He loved to paint watercolours and enjoyed walking in the mountains and gardening. His wife died in 1989.
LIGATION OF THE DORSAL VEIN OF THE PENIS FOR FUNCTIONAL IMPOTENCE, WITH A REPORT OF FIVE CASES.
Authors: J. A. MURRAY
Journal: JAMA (1897)

In reporting these few cases to theAssociationI am not presumptuous enough to claim priority of discovery for the operation. Surgery has advanced so far that, apparently, there are few operations that some one has not done in the recent or remote past. So with this, it may have been done by many surgeons and abandoned. I have seen no literature on the subject, pro or con. If there should prove to be any virtue in the operation I desire to say that I got the idea from the Materia Medica of Dr. Bartholow, in which these words are used: "It has lately been asserted that deficient erections and loss of the capacity for coitus are not infrequently due to enlargement of the dorsal vein of the penis and consequent too rapid emptying of the veins of the erectile tissue. Acting upon this plausible suggestion, the author has practiced
Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population
Authors: Satoshi Arakawa, Atsushi Takahashi, Kyota Ashikawa, Naoya Hosono, Tomomi Aoi, Miho Yasuda, Yuji Oshima, Shigeo Yoshida, Hiroshi Enaida, Takashi Tsuchihashi, Keisuke Mori, Shigeru Honda, Akira Negi, Akira Arakawa, Kazuaki Kadonosono, Yutaka Kiyohara, Naoyuki Kamatani, Yusuke Nakamura, Tatsuro Ishibashi, Michiaki Kubo
Journal: Nature Genetics (2011)
Differential regulation of transforming growth factor-beta receptors type I and II by platelet-derived growth factor in human dermal fibroblasts
Authors: J. Czuwara-Ladykowska, E.A. Gore, D.A. Shegogue, E.A. Smith, M. Trojanowska
Journal: British Journal of Dermatology (2001)

Journal Article Differential regulation of transforming growth factor‐β receptors type I and II by platelet‐derived growth factor in human dermal fibroblasts Get access J. Czuwara‐Ladykowska, J. Czuwara‐Ladykowska Search for other works by this author on: Oxford Academic Google Scholar E.A. Gore, E.A. Gore Search for other works by this author on: Oxford Academic Google Scholar D.A. Shegogue, D.A. Shegogue Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, 96 Jonathan Lucas St, Suite 912, Charleston, SC 29401, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar E.A. Smith, E.A. Smith Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, 96 Jonathan Lucas St, Suite 912, Charleston, SC 29401, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar M. Trojanowska M. Trojanowska Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, 96 Jonathan Lucas St, Suite 912, Charleston, SC 29401, U.S.A. Maria Trojanowska, PhD. E‐mail: trojanme@musc.edu Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 4, 1 October 2001, Pages 569–575, https://doi.org/10.1046/j.1365-2133.2001.04443.x Published: 01 October 2001
The bruit of carotid stenosis versus radiated basal heart murmurs. Differentiation by phonoangiography.
Authors: J P Kistler, R S Lees, J Friedman, M Pressin, J P Mohr, G S Roberson, R G Ojemann
Journal: Circulation (1978)

Phonoangiography, quantitative analysis of arterial bruits, has been shown to provide accurate noninvasive diagnosis of uncomplicated carotid arterial stenosis, but had not been tested where cervical bruits from other sources were present. In this study, 27 carotid bruits in 15 consecutive patients with carotid bruits and basal heart murmurs were analyzed by phonoangiography. Tape recordings were made over the base of the heart and along the course of the carotid arteries in the neck; spectral analysis was performed as previously described. The spectral shape of the basal heart murmurs was recognizable and amplitude decreased with distance from the heart, althouth a secondary, lower amplitude, maximum often occurred over the carotid bifurcation. Intrinsic carotid bruits, by contrast, were always maximal over the bifurcation, and although they radiated both proximally and distally, were not detectable over the chest wall. In quantitative terms, the correct diagnosis as to the presence and extent of carotid stenosis was made in 25 of 27 cases (92%) despite the presence of a radiated murmur. Phonoangiography is capable of accurate differentiation of radiated murmurs from intrinsic carotid bruits and of quantitation of the latter even in the presence of radiated sounds.
Effect of Self-care Book-Reply
Authors: James P. LoGerfo
Journal: JAMA (1981)

<h3>In Reply.—</h3> Vickery and Fries correctly observe that because of large variations in physician visits among any group of persons or families, it is difficult to show a statistically significant impact on physician visits with any intervention. The correct conclusion from our study is that the book alone, or the book plus the financial incentive, does not increase or decrease use of physicians by 21% or more in a prepaid health plan. We calculate that future studies will need nearly 2,500 families to reliably detect a true 7.5% reduction because of the book's effect if populations with similar variability in use are studied. We agree that firm conclusions about increases or decreases of less magnitude than 21% should not be made from this study because of large variances relative to the 700 families in the study. This includes the 7.5% greater decrease among the experimental groups in this study. Since
Network Medicine — From Obesity to the “Diseasome”
Authors: Albert-László Barabási
Journal: New England Journal of Medicine (2007)

A recent study reported that among people who carried a single copy of the high-risk allele for the FTO gene, which is associated with fat mass and obesity, the risk of obesity increased by 30%. The risk of obesity increased by 67% among people who carried two alleles, and on average they gained 3.0 kg (6.6 lb) or more.1 Given that approximately one sixth of the population of European descent is homozygous for this allele, this link between the FTO gene and obesity appears to be one of the strongest genotype–phenotype associations detected by modern genome-screening techniques.That obesity has . . .
Arrhythmogenic Right Ventricular Dysplasia Delineation of Myopathic Site by Intracoronary Thallium-201
Authors: HARUHIKO ADACHI, HIROKI SUGIHARA, HIROAKI NAKAGAWA, SUETSUGU INAGAKI, YASUSHI KUBOTA, TADASHI NAKANISHI, HIROSHI KATSUME, HAMAO IJICHI
Journal: Clinical Nuclear Medicine (1986)

Arrhythmogenic right ventricular dysplasia (ARVD) is characterized by right ventricular (RV) myopathic changes and ventricular tachycardia (VT). Myocardial scintigrams obtained by intracoronary injection of Tl- 201 chloride were useful in the diagnosis of the location and extent of dysplasia in a 23-year-old man.
A CHIEF PREDISPOSING CAUSE OF APPENDICITIS.A PRELIMINARY NOTE WITH A FEW LABORATORY EXPERIMENTS.
Authors: GEORGE RUBIN
Journal: JAMA (1904)

One evening in the fall of last year I was called to the bedside of a man who had suddenly become ill with symptoms typical of acute appendicitis, viz., chills, nausea and vomiting, general abdominal pain and local tenderness over the ileocecal region. The patient's history was as follows: An American, of German extraction, 40 years of age, unmarried, stenographer, almost a total abstainer, and of excellent habits in general. Family history excellent. He has always been well, with the exception of a diarrhea several months ago, of a few weeks' duration, from which he made a complete recovery. For a week or so preceding his last illness he was troubled with flatulency, though it caused him slight inconvenience. After remaining in bed for ten days, and with appropriate medical treatment, the patient made an uneventful recovery from appendicitis. In considering the case in all its bearings, but especially with
A SKIN CANCER FOLLOWING EXPOSURE TO RADIUM
Authors: WARD J. MacNEAL
Journal: JAMA (1923)

The patient, G. S. W.,<sup>1</sup>who was born, Oct. 12, 1876, had attained the age of 46 years in 1922. His father, a physician, died in 1898 at the age of 64, from prostatic hypertrophy complicated by a mitral regurgitation and nephritis. His mother died in 1918 at the age of 70 years, from angina pectoris. The patient is married and has one daughter, aged 21. The patient has practiced medicine since 1899, and he first began working with roentgen rays in 1905, employing a Wagner static machine with attachment for fluoroscopy. He habitually used his left hand as a test object. In 1909 he became acquainted with Dr. Walter Dodd, and for several summers he worked with Dr. Dodd in the Massachusetts General Hospital. He was, therefore, fully cognizant of the danger of roentgen-ray burns because of Dr. Dodd's experience, the latter having undergone no less than forty-six
Predictive value of allergy and pulmonary function tests for the diagnosis of asthma in elite athletes
Authors: M. Bonini, G. Lapucci, G. Petrelli, A. Todaro, T. Pamich, G. Rasi, S. Bonini
Journal: Allergy (2007)

Background: Asthma is frequently found in athletes, often associated with rhinitis and allergy. Aim: To study the predictive value of allergy and pulmonary function tests for the diagnosis of asthma in athletes. Subjects and methods: Ninety‐eight national preOlympic athletes underwent an accurate medical examination including a validated questionnaire for asthma and rhinitis, spirometric recordings and skin prick testing with a panel of the most frequent inhalant allergens. Bronchodilator and/or exercise challenge were also performed in asthmatic subjects. Results: Clinical asthma was present in 20.4% of athletes, rhinitis in 35.3% (in 21.4% of cases alone and in 13.9% associated with asthma). Positive prick tests were recorded in 44.4% of athletes (in 60.5% of asthmatics, in 95.2% of rhinitics and in 21.0% of nonasthmatic – nonrhinitic subjects). Mean spirometric values and distribution of abnormal values were not different among asthmatics, rhinitics and nonasthmatics – nonrhinitic patients. Skin‐tests positivity was not related to the abnormal spirometric data found in individual cases. Provocation tests with bronchodilators or exercise did not appear sensitive enough to diagnose mild forms of asthma in subjects with normal basal spirometric values. Conclusions: Allergy testing and spirometry should be performed routinely in athletes because of the high prevalence of allergy, rhinitis and asthma in this population. However, the predictive value of these tests and of the bronchial provocation tests performed in this study seems too low to document mild or subclinical asthma in athletes.