Verapamil-Induced Hyperprolactinemia and Galactorrhea
Authors: LAWRENCE E. GLUSKIN
Journal: Annals of Internal Medicine (1981)

Brief Reports1 July 1981Verapamil-Induced Hyperprolactinemia and GalactorrheaLAWRENCE E. GLUSKIN, M.D., BORIS STRASBERG, M.D., JAYENDRA H. SHAH, M.D.LAWRENCE E. GLUSKIN, M.D., BORIS STRASBERG, M.D., JAYENDRA H. SHAH, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-1-66 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVerapamil, a synthetic papaverine derivative, has been reported to have antiarrhythmic, antianginal, and antihypertensive properties in man (1). Although verapamil was introduced in Germany in 1962 and has been in use in much of the world, it has been available for clinical investigation in the United States only recently (1). The oral and intravenous use of verapamil is associated with side effects including gastric intolerance, headache, nervousness, pruritis, hypotension, bradycardia, and asystole (2); however, hyperprolactinemia and galactorrhea have not been reported. We report galactorrhea and hyperprolactinemia that occurred during verapamil therapy in a young woman.A 22-year-old woman had a...References1. SINGH B, ELLRODT G, and PETER C. Verapamil: a review of its pharmacological properties and therapeutic use. Drugs. 1978;15:169-97. CrossrefMedlineGoogle Scholar2. SINGH B, COLLETT J, and CHEW C. New perspectives in the pharmacologic therapy of cardiac arrhythmias. Prog Cardiovasc Dis. 1980;22:243-97. CrossrefMedlineGoogle Scholar3. JACOBS L. Prolactin. In: JAFFE BM, BEHRMAN HR, eds. Methods of Hormone Radioimmunoassay. New York: Academic Press; 1974: 87-102. Google Scholar4. FRIESEN H and HWANG P. Human prolactin. Annu Rev Med. 1973;24:251-70. CrossrefMedlineGoogle Scholar5. NAYLER W and SZETO J. Effect of verapamil on contractility, oxygen utilization and calcium exchangeability in mammalian heart muscle. Cardiovasc Res. 1972;6:120-28. CrossrefMedlineGoogle Scholar6. ETO S, WOOD J, HUTCHINS M, and FLEISCHER N. Pituitary 45C++ uptake and release of ACTH, GH, and TSH: effect of verapamil. Am J Physiol. 1974;226(6):1315-20. CrossrefMedlineGoogle Scholar7. LECLERCQ-MEYER V, MARCHAND J, and MALAISSE W. The role of calcium in glucagon release: studies with verapamil. Diabetes. 1978;27:996-1004. CrossrefMedlineGoogle Scholar8. ISAAC R, MERCERON R, CAILLENS G, RAYMOND J, and ARDAILLOU R. Effect of parathyroid hormone on plasma prolactin in man. J Clin Endocrinol Metab. 1978;47:18-23. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LAWRENCE E. GLUSKIN, M.D.; BORIS STRASBERG, M.D.; JAYENDRA H. SHAH, M.D.Affiliations: Veterans Administration West Side Medical Center Abraham Lincoln School of Medicine University of Illinois Chicago, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProlactinHyperprolactinemia in Men with Testosterone DeficiencyProlactinomasProlactinomas in Children and AdolescentsProlactin and Its Role in Human ReproductionProlactinomaBreastfeeding and migraine drugsProlactin in Human ReproductionPhysiological and Pathophysiological Alterations of the Neuroendocrine Components of the Reproductive AxisProlactinTranssphenoidal Surgery for ProlactinomasProlactin in Human ReproductionPhysiologic and Pathophysiologic Alterations of the Neuroendocrine Components of the Reproductive AxisDrugs and prolactinMedication-Induced HyperprolactinemiaAntireproductive effect of the calcium channel blocker amlodipine in male ratsProlactinomas y síndromes hiperprolactinémicosMEDICAL TREATMENT OF PROLACTINOMASMechanism of verapamil calcium channel blockade-induced hyperprolactinemiaVerapamil-Induced Hyperprolactememia Complicated by a Pituitary IncidentalomaVerapamil-induced ?primary? polydipsiaNifedipine, but not verapamil, acutely elevates parathyroid hormone levels in premenopausal womenDopaminergic function in rat brain after oral administration of calcium-channel blockers or haloperidol. A microdialysis studyGynaecomastia in association with calcium antagonistsEffect of calcium channel blockers on serum levels of thyroid hormonesDrug‐Induced GynecomastiaEffects of Calcium Channel Blockade withVerapamil on the Prolactin Responsesto TRH, L-Dopa, and BromocriptinePsychopharmacological properties of calcium channel inhibitorsHyperprolactinemia, Galactorrhea, and AtenololShih-Tseng Lee, MDCalcium antagonist flunarizine hydrochloride affects striatal D2 dopamine receptors in the young adult and aged rat brainDrug Information Analysis ServiceDifferent effects of the calcium antagonists nimodipine and flunarizine on dopamine metabolism in the rat brainEFFECT OF NIFEDIPINE ON THYROTROPIN, PROLACTIN, AND THYROID HORMONE RELEASE IN MAN: A PLACEBO-CONTROLLED STUDYDrug-Induced Changes in Prolactin SecretionHormonal and metabolic effects of calcium channel antagonists in manEffect of different Ca2+ entry blockers on dopamine-induced inhibition of in vitro prolactin secretionDiagnostic work-up of hyperprolactinemic disordersProlactinomasVerapamil in treatment of severe schizophreniaProlactinCalcium Antagonistic Properties of Antimanic CompoundsCompetitive inhibition of [3H]spiperone binding to D-2 dopamine receptors in striatal homogenates by organic calcium channel antagonists and polyvalent cationsCalcium antagonists and endocrine status: lack of effect of oral verapamil on pituitary-testicular and pituitary-thyroid function.Introduction Psychoneuropharmacology and Neuroendocrinology Implications in Neuropsychiatric ResearchGalactorrhea in the adolescentThe effect of enalapril on serum prolactin.Hyperprolactinemia-galactorrhea induced by verapamilClinical use of antiarrhythmic drugsClinical applications of slow channel blocking compoundsCalcium antagonists: A new class of drugsThe influence of nisoldipine — A "calcium entry blocker" on drug induced sterotyped behavior in ratsHyperprolactinemic disorders 1 July 1981Volume 95, Issue 1Page: 66-67KeywordsAnxietyBradycardiaEndocrinologyHeadachesHeartHypotensionInterleukinsPruritus ePublished: 1 December 2008 Issue Published: 1 July 1981 PDF downloadLoading ...