tbuckley/cabot-search huggingface dataset:
Significance of Intraoperative Fibercholangioscopy in the Diagnosis of Biliary Tract Disorders
Authors: T. Popiela, D. Karcz, J. Kulig
Journal: Endoscopy (1978)

Intraoperative fibercholangioscopy allows direct inspection of the entire biliary tree up to the secondary distributaries. In 100 patients with suspected biliary tract pathology on account of endoscopic retrograde cholangiography the following findings were obtained: choledocholithiasis (solitary or multiple) in 66, biliary mud in 4, stricutres in 15, common bile duct carcinoma in 8, choledochal cyst in 1 and extrinsic lesions in 6. Peroral direct transpapillary cholangioscopy is still in an experimental stage but its results are promising.
VIABILITY OF B. ACIDOPHILUS AND B. BULGARICUS IN THE HUMAN INTESTINE
Authors: WALTER L. KULP
Journal: JAMA (1926)

Considerable interest has been aroused concerning the effect of milk feeding on intestinal conditions, from the standpoint of change in intestinal flora and of clinical results. The observations of Metchinkoff and his contemporaries initiated this interest. Published reports of their experiments stimulated a number of investigators to further study of intestinal micro-organisms, particularly the group of gram-positive bacteria belonging to the genus concerned. These investigations show that persons living on a high milk diet often develop an intestinal flora which is composed mostly of grampositive rods of the<i>B. acidophilus</i>and<i>B. bifidus</i>types, more or less to the exclusion of the putrefactive and proteolytic types. Metchinkoff's observations were first made on the peasants of the Balkans. The main article of their diet is sour milk prepared by the fermentation of milk with a mixed culture of micro-organisms. As the predominating species in the sour milks studied by him and
Intrauterine Growth Retardation, Insulin Resistance, and Nonalcoholic Fatty Liver Disease in Children
Authors: Abigail Fraser, Shah Ebrahim, Yoav Ben-Shlomo, George Davey Smith, Debbie A. Lawlor
Journal: Diabetes Care (2007)

We read with interest the article by Nobili et al. (1), who reported results of a case-control study that demonstrated an association between intrauterine growth retardation (defined as small for gestational age [SGA]) and pediatric nonalcoholic streatohepatitis (nonalcoholic fatty liver disease [NAFLD]).

Nobili et al. (1) compared children with NAFLD with hospital control subjects. The choice of control subjects may result in an underestimate of the association between SGA and NAFLD if hospitalized children …
VOICEWrite Medical Charting
Authors: Edward I. Markovich
Journal: JAMA (1993)

If you detest paperwork, loathe double work, regret the state of your medical records, feel compelled by the latest governmental requirements to add essential text to your notes to ensure proper reimbursement, and yearn to provide your patients with additional information on their medical problems and treatment in an efficient and cost-effective manner, or if you just like to read about the cutting edge of innovation as it relates to computerized medical record keeping, then VOICE Write Medical Charting may be of interest to you. VOICEWrite is an intriguing new approach to the problem of medical record keeping, prescription writing, patient education, billing, and letter writing in a medical office or hospital setting. It elegantly marries speech recognition with a sophisticated report writer, allowing the user to dictate medical records directly into the computer.  The dictation system employs a set of utterances, which are translated into the necessary words, phrases,
Oncogenic Transformation by SEI-1 Is Associated with Chromosomal Instability
Authors: Dong-Jiang Tang, Liang Hu, Dan Xie, Qiu-Liang Wu, Yan Fang, Yixin Zeng, Jonathan S.T. Sham, Xin-Yuan Guan
Journal: Cancer Research (2005)

Abstract Amplification of SEI-1, a cell cycle regulatory gene at 19q13.1, is commonly detected in ovarian cancer, suggesting a role in the pathogenesis of ovarian cancer. In the present study, the oncogenic potential of SEI-1 was shown by anchorage-independent growth and tumor formation in nude mice with SEI-1–transfected NIH 3T3 mouse fibroblast cells. Silencing of SEI-1 gene expression by small interfering RNAs in ovarian cancer cell line SKOV3 could inhibit cell growth as well as colony formation on soft agar. Chromosomal alterations including the formation of double minutes were observed in tumor cells derived from SEI-1–transformed NIH 3T3 cells. Micronulei formation, which is an indicator of nuclear abnormality and genomic instability, was markedly increased in SEI-1–transfected cells. These data suggest that the oncogenic role of SEI-1 might be mediated at least in part via an effect on genomic instability. Furthermore, overexpression of SEI-1 was associated with higher tumor grades and late Fesddration Internationale des Gynaecologistes et Obstetristes (FIGO) stages in ovarian carcinomas. These data strongly suggest that SEI-1 plays an important role in the development and progression of ovarian cancer.
Risk factors for accelerated atherosclerosis in patients with systemic lupus erythematosus
Authors: B Marasini, M De Monti, G Ghilardi
Journal: Annals of the Rheumatic Diseases (2004)

No patient had a history of a male twin or a solid organ transplant at the time of biopsy.SLE, systemic lupus erythematosus; CLE, cutaneous lupus erythematosus; DM, dermatomyositis; MF, mycosis fungoides.
Abstract 15917: Low-Energy Three-Stage Electrotherapy Delivered Through Endocardial Leads Terminates Ventricular Tachycardia With Higher Efficacy Than Anti-Tachycardia Pacing
Authors: Ajit Janardhan, Wenwen Li, Sarah R Gutbrod, Timo Weimar, Yoshiyuki Watanabe, Toshinobu Kazui, Michael Yeung, Richard B Schuessler, Igor R Efimov
Journal: Circulation (2011)

INTRODUCTION: Current implantable defibrillators use a high-energy biphasic (BP) shock to terminate VT when anti-tachycardia pacing (ATP) fails. Previously, we showed that multiple monophasic (MP) ...
A case of esophageal and endobronchial anthracosis
Authors: J. Yang, Y. Kim, K. Kim, H. Koo, S. Kim, T. Lee, E. Im, K. Huh, Y. Choi, Y. Kang, S. Kwon
Journal: Endoscopy (2010)

A 55-year-old woman underwent esophagogastroduodenoscopy as part of a general health examination and bronchoscopy for blood-tinged sputum noticed 3 days earlier. She had received treatment for pulmonary tuberculosis 20 years ago, and had been cured. She was a housewife with no history of smoking or occupational exposure to charcoal. A physical examination disclosed no abnormalities and laboratory values were within normal limits. Gastroesophageal endoscopy revealed an approximately 1-cm round, black-pigmented flat lesion with a central depression, at 30 cm from the incisors ([Fig. 1]), and two diverticula with black pigmentation, at 20 cm from the incisors ([Fig. 2]).
Variability of echocardiographic discontinuity in double outlet right ventricle and truncus arteriosus.
Authors: J W French, R Popp
Journal: Circulation (1975)

The widespread application of echocardiography to the field of congenital heart disease has led to the development of a concept of "echocardiographic discontinuity" for the diagnosis of some conditions. Although this is a valuable sign in differentiating such entities as tetralogy of Fallot, truncus arteriosus and double outlet right ventricle, the reported cases illustrate that the echocardiographic recognition of discontinuity may be complicated by technical factors. In addition, the differential diagnosis must include truncus arteriosus with coexistence of anterior and posterior discontinuity.
Subsidising private patients?
Authors: R. B Pridie
Journal: BMJ (1980)

serological tests were obtained in 69 of these patients.Of the remaining 31 patients, significant antibody titres to toxoplasma were obtained in five and to cytomegalovirus in two.In 24 patients the cause of the illness was undiagnosed.In our series the level of atypical lymphocy- tosis was critical: all 19 patients with atypical lymphocytes forming over 450°of the total leucocyte count gave a positive result in the Paul-Bunnell-Davidsohn test; and all 27 patients with over 40%0 of atypical lympho- cytes were either positive in the Paul- Bunnell-Davidsohn test or had significant titres of IgM anti-Epstein-Barr virus anti- bodies.Thus it appears that high levels of lymphocytes (over 40',) are diagnostic of infectious mononucleosis, whereas at lower levels of atypical lymphocytes an appreciable number of patients do not have infectious mononucleosis.
901-6 Psychophysiological Investigations of Myocardial Ischemia (PIMI): Initial Results on Mechanisms of Cardiac Ischemia
Authors: Carl Pepine, Barry Bertolet, Jerome Cohen, David Goldberg, Herman Taylor, Lewis Becker, Robert Bonsall, Peter Stone, Genell Knatterud, Peter Kaufmann, David Sheps
Journal: Journal of the American College of Cardiology (1995)
1,25-Dihydroxyvitamin D3 modulates the expression of a lymphokine (granulocyte-macrophage colony-stimulating factor) posttranscriptionally.
Authors: A Tobler, C W Miller, A W Norman, H P Koeffler
Journal: Journal of Clinical Investigation (1988)

We recently showed that 1,25(OH)2D3 sensitively inhibited the expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in normal human mitogen-activated peripheral blood lymphocytes and in the human T lymphotropic virus I immortalized T cell line known as S-LB1 at the levels of both mRNA and protein. Using S-LB1 cells as a model system the present paper identifies at least in part the mechanisms by which 1,25(OH)2D3 regulates the expression of GM-CSF. Time-course studies demonstrated that by 6 and 48 h of exposure of S-LB1 cells to 1,25(OH)2D3 (10(-8) M) the GM-CSF mRNA levels were reduced by 50 and 90%, respectively. Studies using cycloheximide as a protein synthesis inhibitor showed that the inhibitory action of 1,25(OH)2D3 on GM-CSF expression was dependent on new protein synthesis. In vitro nuclear run-on assays demonstrated that 1,25(OH)2D3 (10(-8) M) did not change the rate of transcription of the GM-CSF gene. The t1/2 of GM-CSF mRNA, however, was profoundly reduced by 1,25(OH)2D3 when transcription was blocked by actinomycin D compared with the half-life of GM-CSF in the presence of actinomycin D alone (t1/2, less than 0.5 and 4 h, respectively). Taken together, these results demonstrate that 1,25(OH)2D3 regulates expression of the lymphokine GM-CSF posttranscriptionally by influencing the stability of GM-CSF mRNA.
Enhancement of Neutrophil Function as a Result of Prior Exposure to Chemotactic Factor
Authors: Dennis E. Van Epps, Mary Lynn Garcia
Journal: Journal of Clinical Investigation (1980)

Exposure of human polymorphonuclear leukocytes (PMN) to chemotactic factor, as well as the migration of PMN through a 5-μm pore-size membrane, results in a PMN population with enhanced chemiluminescence, enhanced capacity for superoxide anion production, and increased Escherichia coli bactericidal activity. The enhanced PMN response resulting from exposure to chemotactic factor was observed with several chemotactic stimuli, including a mixture of casein and autologous serum, chemotactic C5 fragment, and formyl-l-methionyl-l-leucine-l-phenylalanine (f-Met-Leu-Phe). Enhanced levels of chemiluminescence were observed with both soluble stimuli (concanavalin A and phorbol myristate acetate) as well as particulate stimuli (opsonized zymosan).
Infarction and Coronary Insufficiency During Electroconvulsive Therapy
Authors: Ames Fischer
Journal: JAMA (1968)

<h3>To the Editor:—</h3> There may be a flaw in the conclusion reached by Drs. Hussar and Pachter in their recent article on electroconvulsive therapy (<b>204</b>:1004, 1968). They report a case in which a patient with coronary artery disease suffered myocardial infarctions just following two ECT's, spaced three months apart; the second attack was a fatal one. The authors then conclude that these events were more than coincidental, and state: "We reported this case to prove that ECT may become the trigger of coronary death in persons with significant coronary heart disease." Drs. Hussar and Pachter were unable to evaluate their case in the light of a very recent report of a controlled study concerned with the drug modification of ECT.<sup>1</sup>Woodruff et al used electrocardiographic monitoring of ECT's which were either unmodified by anesthetic agents or modified by thiopental or methohexital sodium. They found that the treatment given
Guide wire-assisted cannulation for the prevention of post-ERCP pancreatitis: a systematic review and meta-analysis
Authors: F. Tse, Y. Yuan, P. Moayyedi, G. Leontiadis
Journal: Endoscopy (2013)

<b>Background and study aims:</b> Cannulation techniques are recognized to be important in causing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). However, considerable controversy exists about the usefulness of the guide wire-assisted cannulation technique for the prevention of PEP. This systematic review of randomized controlled trials (RCTs) aimed to compare the guide wire-assisted cannulation technique with the contrast-assisted cannulation technique. <b>Methods:</b> CENTRAL, MEDLINE, EMBASE, CINAHL, and abstracts from Digestive Disease Week and the United European Gastroenterology Week were searched up to February 2012 for RCTs comparing the guide wire-assisted ERCP cannulation technique with the conventional contrast-assisted ERCP cannulation technique. The risk of bias was assessed, and outcomes were pooled by meta-analysis (random-effects model). The primary outcome measure was PEP. Secondary outcome measures included severity of PEP, primary common bile duct (CBD) cannulation success, overall CBD cannulation success, precut sphincterotomy, and other ERCP-related complications. <b>Results:</b> In total, 12 RCTs (3450 patients) were included. The guide wire-assisted cannulation technique significantly reduced PEP compared with the contrast-assisted cannulation technique (risk ratio [RR] 0.51, 95 % confidence interval [CI] 0.32 – 0.82). In addition, the guide wire-assisted cannulation technique was associated with greater primary cannulation success (RR 1.07, 95 %CI 1.00 – 1.15), fewer precut sphincterotomies (RR 0.75, 95 %CI 0.60 – 0.95), and no increase in other ERCP-related complications. Subgroup analyses indicated that this significant risk reduction in PEP with the guide wire-assisted cannulation technique existed only in "non-crossover" trials (RR 0.22, 95 %CI 0.12 – 0.42). The results were robust in sensitivity analyses. <b>Conclusion: </b>Compared with the contrast-assisted cannulation technique, the guide wire-assisted cannulation technique increases the primary cannulation rate and reduces the risk of PEP, and therefore appears to be the most appropriate first-line cannulation technique.
TURNER SYNDROME AORTOPATHY DEMONSTRATED BY CARDIAC MRI-DETERMINED AORTIC PULSE WAVE VELOCITY
Authors: Sean Hagenbuch, Kan N. Hor, Wojciech Mazur, Robert J. Fleck, Phillipe Backeljauw, D Woodrow Benson, William M. Gottliebson, Janaka Wansapura
Journal: Journal of the American College of Cardiology (2010)
Aspects of audit. 5: Looking forward to audit.
Authors: C D Shaw
Journal: BMJ (1980)

Whatever the misgivings of individual doctors, the formal support being given by professional bodies suggests that medical audit will become established in Britain. It is therefore appropriate to heed the advice of pioneers in the field in choosing methods and topics for audit. Practical problems can be anticipated because of the inadequacy of medical records, retrieval systems, and comparable information on practice patterns and evaluation of traditional processes of patient care. The criterion system of audit may provide a common standard for effective review. This can be used for any group of patients with some characteristic in common. It requires good records and a good records staff. Whatever method is adopted, central support should come from the royal colleges, with community physicians and clinical tutors assisting clinicians at the local level.
NHS Direct will cover England by end of 2000
Authors: L. Beecham
Journal: BMJ (1999)

The health secretary, Frank Dobson, has announced that NHS Direct—the nurse led 24 hour telephone helpline—will be available throughout England by the end of 2000. It currently operates from nine existing sites, giving 10 million people access to the service, and there are plans to launch another seven this year.

It is also proposed that the service will move into new activities—for example, health promotion, the establishment of 200 …
The Treatment of Certain Mental Diseases by Ringer-Locke Solution
Authors: J. P. Steel
Journal: BMJ (1927)

MENTAL DISEASE TREATED BY RINGERIiOCKE SOLUTION.EDM JO "XA 11177 The 6 per cent, of cases that ultimately develop signs of general tuberculosis could be accounted for by an infection with the human type of tubercle bacilli.The common symptoms of acidosis may be explained by the interference with the supply of fats to the liver.The child's metabolism is easily disturbed.Frew showed that the urine of most children suffering from any acute disease contained acetone.The lower ileum and the appendix are great absorbers of fat; appendical concretions are chiefly fat.A calcification and fibrosis of the glands of the ileo- caecal angle must to a great extent interfere with the supply of fat to the liver, and set up acidosis.It seems to me that this acidosis has some relation to the onset of the acute attack of pain in the right iliiac region.A dietetio inidiscretion, a period of nervous strain, or muscular exer- tion often starts an attack.Many organisms lie latelnt till an acid is piesented to them.In children first come the symptoms of acidosis, headache, drowsiness, and then pain.The pain has been attributed to different causes by different observers.Corner thought it was due to the reflex action on the appendix.Carson attributed the pain to the irritation of the mesenteric nerves causing enterospasm.This, he thinks, explains the colicky nature of tho pain, and its sudden onset and cessation.He tictually saw an intussusception occurring when he was bperating on a case of lymphadenitis.Probablv Carson's oxplanation holds good in many cases.It would explain the colicky pain at the umbilicus at the beginning of an attack.The shifting of the pain to the right must be
High-dose IL-2 in metastatic melanoma: better survival in patients who also received patient-specific autologous tumor cell vaccine
Authors: Robert O Dillman, Carol DePriest, Stephanie E McClure
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Treatment with high-dose Interleukin-2 (IL-2) has been associated with long-term survival in small proportion of metastatic melanoma patients. We recently reported a median survival of 15.6 months, and a 20% 5-year survival rate for 150 such patients who were hospitalized for high
Bioengineered Three-Layered Robust and Elastic Artery Using Hemodynamically-Equivalent Pulsatile Bioreactor
Authors: Kiyotaka Iwasaki, Koji Kojima, Shohta Kodama, Ana C. Paz, Melody Chambers, Mitsuo Umezu, Charles A. Vacanti
Journal: Circulation (2008)

Background— There is an essential demand for tissue engineered autologous small-diameter vascular graft, which can function in arterial high pressure and flow circulation. We investigated the potential to engineer a three-layered robust and elastic artery using a novel hemodynamically-equivalent pulsatile bioreactor. Methods and Results— Endothelial cells (ECs), smooth muscle cells (SMCs), and fibroblasts were harvested from bovine aorta. A polyglycolic acid (PGA) sheet and a polycaprolactone sheet seeded with SMCs, and a PGA sheet seeded with fibroblast, were wrapped in turn on a 6-mm diameter silicone tube and incubated in culture medium for 30 days. The supporting tube was removed, and the lumen was seeded with ECs and incubated for another 2 days. The pulsatile bioreactor culture, under regulated gradual increase in flow and pressure from 0.2 (0.5/0) L/min and 20 (40/15) mm Hg to 0.6 (1.4/0.2) L/min and 100 (120/80) mm Hg, was performed for an additional 2 weeks (n=10). The engineered vessels acquired distinctly similar appearance and elasticity as native arteries. Scanning electron microscopic examination and Von Willebrand factor staining demonstrated the presence of ECs spread over the lumen. Elastica Van Gieson and Masson Tricrome Stain revealed ample production of elastin and collagen in the engineered grafts. Alpha-SMA and calponin staining showed the presence of SMCs. Tensile tests demonstrated that engineered vessels acquired equivalent ultimate strength and similar elastic characteristics as native arteries (Ultimate Strength of Native: 882±133 kPa, Engineered: 827±155 kPa, each n=8). Conclusions— A robust and elastic small-diameter artery was engineered from three types of vascular cells using the physiological pulsatile bioreactor.
Parzival's Pericardial Puncture
Authors: W. EDMUND FARRAR
Journal: Annals of Internal Medicine (1980)

Brief Reports1 May 1980Parzival's Pericardial PunctureW. EDMUND FARRAR Jr, M.D.W. EDMUND FARRAR Jr, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-5-640 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAccording to Kotte and McGuire (1) aspiration of the pericardium was first performed in 1819 by Romero. But I believe the procedure was described at least 600 years earlier—in Parzival, the medieval German heroic poem written around 1200 by Wolfram von Eschenbach (2).Then my lord Gawan dismounted. There lay a man pierced through, with his blood rushing inward. He asked the hero's lady whether the knight were still alive or in the throes of death."Sir," she replied, "he is still alive, but I think it will not be for long. God has sent you here for my comfort....References1. KOTTEMCGUIRE JJ. Pericardial paracentesis. Mod Concepts Cardiovasc Dis. 1951;20:102-3. MedlineGoogle Scholar2. WOLFRAM VON E Parzival. Translated by MUSTARD HM, PASSAGE CE. New York: Random House (Vintage Books); 1961;270-1. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByA Historical Perspective 1 May 1980Volume 92, Issue 5Page: 640-640KeywordsBloodPericardium Issue Published: 1 May 1980 PDF DownloadLoading ...