Bilateral Renal-vein Thrombosis and the Nephrotic Syndrome in Adults
Authors: LAURENCE J. MCCARTHY
Journal: Annals of Internal Medicine (1963)

Article1 May 1963Bilateral Renal-vein Thrombosis and the Nephrotic Syndrome in AdultsLAURENCE J. MCCARTHY, M.D., JACK L. TITUS, M.D., PH.D., GUY W. DAUGHERTY, M.D., F.A.C.P.LAURENCE J. MCCARTHY, M.D., JACK L. TITUS, M.D., PH.D., GUY W. DAUGHERTY, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-5-837 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe nephrotic syndrome may be defined as a clinical state resulting from a renal disorder and characterized by edema, hyperlipemia, hypoproteinemia, and massive proteinuria. The underlying renal condition may be any one of several disease processes (1-7), including thrombosis of both renal veins. Harrison, Milne, and Steiner (8) recognized 4 etiologic varieties of renal-vein thrombosis: [1] thrombosis of the inferior vena cava and renal veins secondary to extension of thrombi from pelvic or leg veins; [2] thrombotic occlusion of the inferior vena cava secondary to invasion by a malignant neoplasm, especially hypernephroma, or to external compression by tumor; [3] renal-vein...References1. ADAMS DA: The pathophysiology of the nephrotic syndrome. Arch. Intern. Med. (Chicago) 106: 117, 1960. CrossrefMedlineGoogle Scholar2. ALLEN AC: The clinicopathologic meaning of the nephrotic syndrome. Amer. J. Med. 18: 277, 1955. CrossrefMedlineGoogle Scholar3. BERMANSCHREINER LBGE: Clinical and histologic spectrum of the nephrotic syndrome. Amer. J. Med. 24: 249, 1958. CrossrefMedlineGoogle Scholar4. FINDLEY T: The nephrotic syndrome. Amer. Heart J. 61: 822, 1961. CrossrefMedlineGoogle Scholar5. KARKPIRANIPOLLAKMUEHRCKEBLAINEY RMCLVERCJD: The nephrotic syndrome in adults: a common dis-order with many causes. Ann. Intern. Med. 49: 751, 1958. LinkGoogle Scholar6. POLLAKKARKPIRANISHAFERMUEHRCKE VERMCLHLRC: Renal vein thrombosis and the nephrotic syndrome. Amer. J. Med. 21: 496, 1956. CrossrefMedlineGoogle Scholar7. SQUIREBLAINEYHARDWICKE JRJDJ: The nephrotic syndrome. Brit. Med. Bull. 13: 43, 1957. CrossrefMedlineGoogle Scholar8. HARRISONMILNESTEINER CVMDRE: Clinical aspects of renal vein thrombosis. Quart. J. Med. 25: 285, 1956. MedlineGoogle Scholar9. ALLEN AC: Thrombosis of renal veins, in The Kidney: Medical and Surgical Diseases, Grune & Stratton, Inc., New York, 1951, p. 470. Google Scholar10. BURCHPEARLSTERNBERG RRMAWH: A clinicopathological study of the nephrotic syndrome. Ann. Intern. Med. 56: 54, 1962. LinkGoogle Scholar11. JOEKESHEPTINSTALLPORTER AMRHKA: The nephrotic syndrome. Quart. J. Med. 27: 495, 1958. MedlineGoogle Scholar12. FEINERMANBURKEBAHN BECRC: The nephrotic syndrome associated with renal vein thrombosis: report of case in an infant. J. Pediat. 51: 385, 1957. CrossrefMedlineGoogle Scholar13. RAYER PF: Traité des maladies des reins et des altérations de la sécrétion urinaire, étudiées en elles-mêmes et dans leurs rapports avec les maladies des uretères, de la vessie, de la prostate, le l'urèthre. Paris, J.-B. Baillière, 1839-1841, 3 vol. Google Scholar14. ALSLEV J: Nierenvenenthrombose und nephrotisches Syndrom. Verh. Deutsch. Ges. Inn. Med. 65: 652, 1959. MedlineGoogle Scholar15. BALSLØV JT: Nefrotisk syndrom ved dobbeltsidig nyrevenethrombose hos to hjertepatienter. Ugeskr. Laeg. 121: 197, 1959. MedlineGoogle Scholar16. BATZENSCHLAGERMÉRIANPORTE AEA: Lésions glomerulaires dans la thrombose ancienne des veines rénales avec syndrome néphrotique. Ann. Anat. Path. (Paris) 3: 294, 1958. MedlineGoogle Scholar17. BLAINEYBREWERHARDWICKESOOTHILL JDDBJJF: The nephrotic syndrome: diagnosis by renal biopsy and biochemical and immunological analyses related to the response to steroid therapy. Quart. J. Med. 29: 235, 1960. MedlineGoogle Scholar18. BOULETMIROUZEBARJONMANDIN PJPA: Valeur des investigations faites pour déceles une thrombose des veines rénales au cours des syndromes néphrotiques de l'adulte. Bull. Soc. Méd. Hôp. Paris 75: 657, 1959. MedlineGoogle Scholar19. BRUMFITTO'BRIEN WW: Renal vein thrombosis with nephrotic syndrome and renal failure. Brit. Med. J. 2: 751, 1956. CrossrefMedlineGoogle Scholar20. CASTLEMANKIBBEE BBU: Case records of the Massachusetts General Hospital: case 10—1962. New Engl. J. Med. 266: 302, 1962. Google Scholar21. CHURGGRISHMAN JE: Subacute glomerulonephritis. Amer. J. Path. 35: 25, 1959. MedlineGoogle Scholar22. HILDENNEILSEN ATOE: Nyrevenethrombose med. nefrotisk syndrom. Nord. Med. 62: 1108, 1959. MedlineGoogle Scholar23. DE SWIETWELLS JAL: Nephrotic syndrome associated with renal venous thrombosis and bronchial carcinoma. Brit. Med. J. 1: 1341, 1957. CrossrefMedlineGoogle Scholar24. ABESHOUSE BS: Thrombosis and thrombophlebitis of the renal veins. Urol. Cutan. Rev. 49: 661, 1945. MedlineGoogle Scholar25. VALLERY-RADOTMILLIEZLAROCHEDEBRAYMARTIN PPCPJ: Un cas de thrombose primitive des deux veines rénales. Bull. Soc. Méd. Hôp. Paris 1: 611, 1949. Google Scholar26. MOVATMCGREGOR HZDD: The fine structure of the glomerulus in membranous glomerulonephritis (lipoid nephrosis) in adults. Amer. J. Clin. Path. 32: 109, 1959. CrossrefMedlineGoogle Scholar27. SPIRO D: Electron microscopic studies in renal biopsies on patients with proteinuria, in Proceedings of the Eleventh Annual Conference on the Nephrotic Syndrome, ed. by Metcoff, J., National Kidney Disease Foundation, New York, 1960, p. 171. Google Scholar28. BELL ET: Clinical and pathological study of subacute and chronic glomerulonephritis, including lipoid nephrosis. Amer. J. Path. 14: 691, 1938. MedlineGoogle Scholar29. ELLIS A: Natural history of Bright's disease: clinical, histological and experimental observations. Lancet 1: 1, 1942. CrossrefGoogle Scholar30. FOLLIPOLLAKREIDPIRANIKARK GVERTCLRM: Electronmicroscopic studies of reversible glomerular lesions in the adult nephrotic syndrome. Ann. Intern. Med. 49: 775, 1958. LinkGoogle Scholar31. FARQUHARVERNIERGOOD MGRLRA: An electron microscope study of the glomerulus in nephrosis, glomerulonephritis, and lupus erythematosus. J. Exp. Med. 106: 649, 1957. CrossrefMedlineGoogle Scholar32. POWELLSPARGOARNOLD RDBJD: Clinical and electron microscopic studies in patients with the nephrotic syndrome. JAMA 177: 196, 1961. CrossrefMedlineGoogle Scholar33. MUELLERMASONSTOUT CBADDG: Anatomy of the glomerulus. Amer. J. Med. 18: 267, 1955. CrossrefMedlineGoogle Scholar34. FELDMAN J: Discussion, in Proceedings of the Tenth Annual Conference on the Nephrotic Syndrome, National Kidney Disease Foundation, New York, 1959, p. 25. Google Scholar35. SPIRO D: The structural basis of proteinuria in man: electron microscopic studies on renal biopsy specimens from patients with lipid nephrosis, amyloidosis, and subacute and chronic glomerulonephritis. Amer. J. Path. 35: 47, 1959. MedlineGoogle Scholar36. KELLY RE: Discussion. Proc. Roy. Soc. Med. 22: 1514, 1929. Google Scholar37. MAYO WJ: The splenic syndromes. Coll. Papers Mayo Clin. and Mayo Foundation 17: 625, 1925. Google Scholar38. SALTERSHERLOCK PPEC: Splenectomy, thrombocytosis and venous thrombosis. Amer. Surg. 23: 549, 1957. MedlineGoogle Scholar39. OMAEMASSONCORCORAN TGMAC: Experimental production of nephrotic syndrome following renal vein constriction in rats. Proc. Soc. Exp. Biol. Med. 97: 821, 1958. CrossrefMedlineGoogle Scholar40. BAIRDBUCHANAN WLDP: The nephrotic syndrome following thrombosis of the inferior vena cava. Amer. J. Med. 32: 128, 1962. CrossrefMedlineGoogle Scholar41. LENG-LEVYDAVID-CHAUSSEGIBAUDVITAL JJHC: Thrombose des veines rénales avec syndrome néphrotique: rémission de quatre ans, rechute, amélioration: Étude clinique, biologique, radiologique et biopsique. Bull. Soc. Méd. Hôp. Paris 1: 453, 1960. Google Scholar42. DILLARDLYONSSALTER RACPP: Thrombosis of the vena cava to the level of the renal veins with recovery. Amer. Surg. 23: 539, 1957. MedlineGoogle Scholar43. GREGGSCHIRGERHARRISON JAAEG: Thrombosis of the renal veins associated with hypertension: report of case. Proc. Mayo Clin. 36: 550, 1961. MedlineGoogle Scholar44. EHRICH W: Discussion, in Proceedings of the Fifth Annual Conference on the Nephrotic Syndrome. National Nephrosis Foundation, Inc., New York, 1953, p. 127. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LAURENCE J. MCCARTHY, M.D.; JACK L. TITUS, M.D., PH.D.; GUY W. DAUGHERTY, M.D., F.A.C.P.Affiliations: Rochester, MinnesotaFrom the Mayo Foundation and Mayo Clinic, Rochester, Minnesota.Requests for reprints should be addressed to Mayo Clinic, Rochester, Minnesota. 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POLLAK, M.B., F.R.C.P.E., CONRAD L. PIRANI, M.D., COLEMAN SESKIND, M.D., BENJAMIN GRIFFEL, M.D.Renal Vein ThrombosisDie Gefäßerkrankungen der Niere 1 May 1963Volume 58, Issue 5Page: 837-857KeywordsEdemaElectron microscopyHyperlipidemiaHypoproteinemiaInferior vena cavaProteinuriaRenal cancerRenal diseasesThrombosisVeins ePublished: 1 December 2008 Issue Published: 1 May 1963 PDF downloadLoading ...