tbuckley/cabot-search huggingface dataset:
Arthritis and Allied Conditions
Authors: W. S. C. Copeman
Journal: Annals of the Rheumatic Diseases (1950)

assessment couched in vague terms (such as " much better ", " improved ", i' results good ") are of no real significance in modern scientific investigation.The more thoughtful reader would like to see more evidence brought forward in substantiation of the therapeutic claims made.Such evidence would require follow-up reports and the use of standards of assessment of disability and progress adequate to the demands of modern research.The addition of such a chapter would add considerably to the value of this book.
Cutaneous graft-versus-host-like histology in childhood. Importance of clonality analysis in differential diagnosis. A case report
Authors: A. D’hauw, M.M.B. Seyger, P.J.T.A. Groenen, C.M.R. Weemaes, A. Warris, W.A.M. Blokx
Journal: British Journal of Dermatology (2008)

Journal Article Cutaneous graft‐versus‐host‐like histology in childhood. Importance of clonality analysis in differential diagnosis. A case report Get access A. D’hauw, A. D’hauw Departments of Pathology Search for other works by this author on: Oxford Academic Google Scholar M.M.B. Seyger, M.M.B. Seyger Dermatology Search for other works by this author on: Oxford Academic Google Scholar P.J.T.A. Groenen, P.J.T.A. Groenen Departments of Pathology Search for other works by this author on: Oxford Academic Google Scholar C.M.R. Weemaes, C.M.R. Weemaes Paediatrics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, the Netherlands Correspondence: W.A.M. Blokx. E‐mail: w.blokx@pathol.umcn.nl Search for other works by this author on: Oxford Academic Google Scholar A. Warris, A. Warris Paediatrics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, the Netherlands Correspondence: W.A.M. Blokx. E‐mail: w.blokx@pathol.umcn.nl Search for other works by this author on: Oxford Academic Google Scholar W.A.M. Blokx W.A.M. Blokx Departments of Pathology Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 158, Issue 5, 1 May 2008, Pages 1153–1156, https://doi.org/10.1111/j.1365-2133.2008.08497.x Published: 01 May 2008
Bibliometric Analysis of <i>Theranostics</i>: Two Years in the Making
Authors: Don N. Ho, Ki Young Choi, Sung-Jong Lee
Journal: Theranostics (2013)

With the newly released impact factor from Thomson Reuters, we look at the first two years of the journal Theranostics under the scope of a new bibliometric designed for the analysis of emerging specialties and also for journals with a multidisciplinary approach.With this method, we are able to look at characteristics of an interdisciplinary field or a single journal subject area, and also, the bibliographic trends of their authors.We use this tool to examine authors from the journal Theranostics and compare them to similar authors in the field of theranostics, or theranosticians.Our document and co-citation analysis examines the growth and overlap of established knowledge networks with the incorporation of fields, topics, and disciplines; the quantification can also reflect the intellectual activity in combining leading edge developments in solidly grounded specialties.The quantification of junior authorship aims to gauge the promotion of fresh ideas and scientific development in the community, while productivity of overall authors is measured by citation analysis.
Superiority of high-dose over intermediate-dose cytosine arabinoside in the treatment of patients with high-risk acute myeloid leukemia: results of an age-adjusted prospective randomized comparison
Authors: W Kern, C Aul, G Maschmeyer, R Schönrock-Nabulsi, WD Ludwig, A Bartholomäus, P Bettelheim, B Wörmann, T Büchner, W Hiddemann
Journal: Leukemia (1998)
An odd eruption
Authors: A. Abdul-Wahab, P. Banerjee
Journal: BMJ (2011)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following An odd eruption Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Long-term haemodialysis without transfusion or drugs.
Authors: H Yatzidis, D Triantafillidis, C Koutsoyannis, S Voudiclaris, P Digenis
Journal: BMJ (1971)

entity; Harkness, in his classic monograph, names more than 50 conditions known to cause urethritis.8One of these is post- dysenteric Reiter's syndrome.The situation is obviously confusing, and your leading article (14 August, p. 386) care- fully avoided the textbook statement that Reiter's syndrome is usually a complication of venereally acquired non-gonococcal urethritis.Nevertheless, in the statement that the incidence of the disease is estimated at about 1 /,, of the patients with non- gonococcal urethritis it perpetuates the text- book teaching without mentioning any of the discordant facts.A pedantic approach is often necessary to make a difficult subject intelligible to students; it is unfortunate that this some- times carries over into scientific thought and clinical practice.-Iam, etc.,
Upregulation and coexpression of adhesion molecules correlate with relapsing autoimmune demyelination in the central nervous system.
Authors: B Cannella, A H Cross, C S Raine
Journal: The Journal of Experimental Medicine (1990)

The expression of adhesion molecules on central nervous system (CNS) vessels was examined during chronic relapsing experimental autoimmune encephalomyelitis in the SJL mouse. Two molecules associated with cell adhesion were studied: MECA-325, a murine lymph node high endothelial venule marker; and MALA-2, the murine homologue of intercellular adhesion molecule 1. During initial disease, upregulated coexpression of these two molecules occurred in the CNS. This correlated with inflammatory cell invasion. During remission, expression was downregulated, and each subsequent relapse was accompanied by corresponding upregulation. Thus, up- and downregulation of adhesion molecules in the target organ appeared to form an integral part of the inflammatory process in this autoimmune condition and support a role for receptor-mediated inflammatory cell invasion of relevance to the pathogenesis of multiple sclerosis.
Structure and Correlates of Diabetes-Specific Locus of Control
Authors: Mark Peyrot, Richard R Rubin
Journal: Diabetes Care (1994)

OBJECTIVE To examine the structure and correlates of diabetes-specific locus of control. RESEARCH DESIGN AND METHODS Study participants were 165 adult patients from a comprehensive outpatient diabetes education program who completed a research protocol at the outset of the program. The protocol included measures of diabetes locus of control (DLC), glycemie control, self-care behavior, and emotional well-being. RESULTS Scales measuring internal and powerful other DLC each had two components. One component of internal DLC, autonomy, was significantly associated with positive outcomes, and the other component, self-blame, was related to negative outcomes. The two components of powerful other DLC were differently correlated with various aspects of strict regimen adherence, and chance DLC was associated with a variety of measures reflecting a pattern of dysfunction. CONCLUSIONS The concept of DLC appears to have explanatory power in accounting for health outcomes, especially when internal DLC measures of autonomy and self-blame are differentiated. It is important to find educational interventions that work effectively with patients who believe that health outcomes are controlled by chance, because they seem to be at special risk for health-related problems.
Waterborne diseases pose threat in Pakistan as floods strike
Authors: Owen Dyer
Journal: BMJ (2007)

The UK government has announced a review of the NHS in a bid to ensure that clinical priorities and local accountability are paramount in the health service's day to day operations.The health secretary, Alan Johnson, has asked the junior health minister and surgeon Sir Ara Darzi to lead the review and to consult widely with patients and staff.The move is widely seen as a bid to mend relationships with health professionals, many of whom feel aggrieved by a decade of nonstop NHS reforms.Mr Johnson said that providing more accessible and convenient care for patients; achieving better value for money; and ensuring that people with long term illness were "treated with dignity in safe, clean environments" were all key areas that the review would look at.He also announced an extra £50m (€74m; $100m) to fight hospital acquired infections.Mr Johnson said, "The past 10 years have seen huge improvements in the NHS, and thanks to record investment and measures to raise standards, nine out of 10 patients rate their care as good to excellent."He added, "What was right for the last decade-top down targets and important but sometimes difficult reforms-will not be right for the next, where more local decision making and staff empowerment need to drive the NHS."He said that the review could result in an NHS constitution that sets out its values and lines of accountability.The full report will be published in June 2008.An interim assessment in autumn 2007 will inform the next comprehensive spending review.Gill Morgan, chief executive of the NHS Confederation, said, "We hope that this is not just another review but a genuine exercise in listening and understanding where the service has got to and where it needs to go.The opportunity to re-engage staff with the NHS reform programme is too important to be missed.
The Detection of Occult Phlebitis With Tc-99m Stannous Fluoride Colloid Labeled White Blood Cell Scintigraphy
Authors: K. W. CHAN, I. E.T. STEWART, C. METREWELI
Journal: Clinical Nuclear Medicine (1995)

Unusual localization of labeled white cells (In-111 and Tc-99m) have been described in many organs. The causes described include infection, trauma, and hetero-topic bone formation. The authors present a case of lower limb deep venous localization of Tc-99m stannous fluoride colloid labeled white cells associated with intravenous infusion on the dorsum of the same foot.
Open clinical trials
Authors: P. Sedgwick
Journal: BMJ (2012)

Researchers assessed the effectiveness of adenotonsillectomy in children with mild symptoms of throat infections or adenotonsillar hypertrophy. An open randomised controlled trial was performed. Control treatment consisted of watchful waiting. In total, 300 children aged 2-8 years were recruited and randomised to adenotonsillectomy (n=151) or control (n=149).1

The main outcome measures included episodes of fever, throat infections, upper respiratory tract infections, and health related quality of life. The researchers reported that adenotonsillectomy had no major clinical benefits over watchful waiting in children with mild symptoms of throat infections or adenotonsillar hypertrophy.

Which of the following types of bias, …
Hydrolyzable hemoglobin adducts of polyfunctional monocyclic N-substituted arenes as dosimeters of exposure and markers of metabolism.
Authors: I Zwirner-Baier, F J Kordowich, H G Neumann
Journal: Environmental Health Perspectives (1994)

Hemoglobin adducts of 10 polyfunctional amino- and nitro-substituted benzenes and toluenes were analyzed: 2,4,6-trinitrotoluene, 2,4- and 2,6-dinitrotoluene, 2-amino-4-nitrotoluene, 4-amino-2-nitrotoluene, 2,4- and 2,6-diaminotoluene, 1,3-dinitrobenzene, 1-amino-3-nitrobenzene, and 1,3-diaminobenzene. A single dose (0.5 mmole/kg) of the test compounds was administered to female Wistar rats by gavage, and blood extracted and hemoglobin prepared after 24 hr. One or more cleavage products could be obtained in each case by hydrolyzing hemoglobin (Hb). Hemoglobin binding indices (HBI: binding [mmole/mole Hb]/dose [mmole/kg]) and the ratios of hydrolyzable adducts were determined. The HBI ranged between < 0.02 and 69.0. The results indicate the in vivo formation of several, covalently bound, hydrolyzable hemoglobin adducts. Conclusions on prevailing metabolic pathways can be drawn. Total binding of several compounds seems sufficient for biomonitoring of human blood samples. These chemicals are considered representative for environmental contamination with explosives of this type, and we propose their Hb adducts be used as dosimeters for human exposure to these suspected carcinogens.
Coating of biomaterial scaffolds with the collagen-mimetic peptide GFOGER for bone defect repair
Authors: Abigail M. Wojtowicz, Asha Shekaran, Megan E. Oest, Kenneth M. Dupont, Kellie L. Templeman, Dietmar W. Hutmacher, Robert E. Guldberg, Andrés J. García
Journal: Biomaterials (2009)
Postprandial Serum Bile Acid for the Detection of Hepatobiliary Disease
Authors: Neil Kaplowitz
Journal: JAMA (1973)

Fasting and two-hour postprandial serum bile acid concentrations were measured in ten normal subjects and 26 patients with hepatobiliary disease. The two-hour postprandial serum bile acid was the only test with abnormal results in all 26 cases. No significant postprandial elevations occurred in normal controls. Ten patients had abnormal twohour postprandial serum bile acid values in association with normal fasting levels, and all showed a minimum 70% two-hour postprandial increase. A two-hour postprandial serum bile acid determination is a sensitive screening test for hepatobiliary disorders.
Bacterial lipopolysaccharides induce in vitro degradation of cartilage matrix through chondrocyte activation.
Authors: H E Jasin
Journal: Journal of Clinical Investigation (1983)

The present studies demonstrate that bacterial lipopolysaccharides (LPS) induce cartilage matrix degradation in live explants in organ culture. Quintuplicate bovine nasal fibrocartilage explants cultured for 8 d with three different purified LPS preparations derived from Escherichia coli and Salmonella typhosa at concentrations ranging from 1.0 to 25.0 micrograms/ml resulted in matrix proteoglycan depletion of 33.3 +/- 5.8 to 92.5 +/- 2.0% (medium control depletion 17.7 +/- 0.7 to 32.4 +/- 1.4%). Matrix degradation depended on the presence of live chondrocytes because frozen-thawed explants incubated with LPS failed to show any proteoglycan release. Moreover, the addition of Polymyxin B (25 micrograms/ml) to live explants incubated with LPS abolished matrix release, whereas Polymyxin B had no effect on the matrix-degrading activity provided by blood mononuclear cell factors. A highly purified Lipid A preparation induced matrix degradation at a concentration of 0.01 micrograms/ml. Cartilage matrix collagen and proteoglycan depletion also occurred with porcine articular cartilage explants (collagen release: 18.3 +/- 3.5%, medium control: 2.1 +/- 0.5%; proteoglycan release: 79.0 +/- 5.9%, medium control: 28.8 +/- 4.8%). Histochemical analysis of the cultured explants confirmed the results described above. Gel chromatography of the proteoglycans released in culture indicated that LPS induced significant degradation of the high molecular weight chondroitin sulfate-containing aggregates. These findings suggest that bacterial products may induce cartilage damage by direct stimulation of chondrocytes. This pathogenic mechanism may play a role in joint damage in septic arthritis and in arthropathies resulting from the presence of bacterial products derived from the gastrointestinal tract.
Non-adrenergic non-cholinergic inhibitory innervation shown by electrical field stimulation of isolated strips of human gall bladder muscle.
Authors: M L McKirdy, H C McKirdy, C D Johnson
Journal: Gut (1994)

Non-adrenergic non-cholinergic (NANC) inhibitory nerves have been described in all regions of the gastrointestinal tract, but have not been shown previously in the human gall bladder. Electrical field stimulation was used in the presence of various agonists and antagonists to show NANC inhibitory innervation in strips of human gall bladder muscle. Gall bladder strips were set up isometrically in an organ bath containing oxygenated Krebs's solution. Electrical field stimulation was applied at 10 Hz, pulse width 0.3 ms and supramaximal voltage at intervals of 3 to 5 minutes. Of 60 strips that contracted in response to electrical field stimulation, 30 showed relaxation on electrical field stimulation in the presence of either carbachol (5-10 microM) or else atropine (0.5-2 microM) plus cholecystokinin octapeptide (0.01-0.1 microM) or caerulein (0.1 nM) or histamine (5-10 microM). In 22 strips this relaxation was not abolished by guanethidine (2-5 microM) showing the NANC nature of this response. The NANC relaxation was abolished by L-nitroarginine (100 microM) and this effect was partly reversible by L arginine (200 microM). All responses to electrical field stimulation were abolished by tetrodotoxin (0.2-2 microM). These results show for the first time a NANC inhibitory innervation in human gall bladder muscle. The probable neurotransmitter is nitric oxide.
Cancer, F.D.P., and radiotherapy.
Authors: B Astedt, L Svanberg, I M Nilsson
Journal: BMJ (1972)

47improvement as demonstrated by reduction or in some cases disappearance of spon- taneous pain in walking (so much so that after many years two patients were able to go upstairs without pause).The rheographic tracing was not modified in one case; in six others it showed an im- provement both in baseline conditions and after trinitrin.More prolonged and extended trial is needed to confirm the preliminary observations.
Software company defends sale of patients' data to drug companies
Authors: Bob Burton
Journal: BMJ (2005)

The largest retailer of specialist software for general practitioners has sought to quell disquiet over the sale of information from patients' electronic files to consultants advising the drug industry. The data on patients is anonymised, but companies are able to extract from it doctors' prescribing patterns.

In an email to doctors, Edmund Bateman, the managing director of Primary Health Care, a healthcare services company, responded to critics of the practice, saying that “it is offensive to suggest we are interested in providing confidential records to anyone.”

Health Communications Network, a subsidiary of Primary Health Care, has sold a software program, Medical …
Abstract B11: Expression analysis of 2D versus 3D culture growth in HEY ovarian cancer cells
Authors: Trillitye Lotito, Chase Powell, Christopher Menzie, Candice Aiosa, Feng Cheng, Sandy Westerheide
Journal: Clinical Cancer Research (2013)

Abstract Human tissue culture has many uses in cancer research. For example, this technique allows for a simple method of testing potential anti-cancer drugs. However, standard 2D cell culture seldom yields the same results in clinical testing. This may be due to the cell culture being exposed to a much different environment than what can be found at its site of origin, including the cellular interactions found in a 3D tumor. A cell culture spheroid model can alleviate some of these issues, creating a 3D version of the culture which more closely represents the cellular conditions experienced by a tumor. We were interested in determining which genes are most affected by 3D growth. Here, we have performed expression analysis on 2D versus 3D HEY ovarian cancer cells. Interestingly, we show that expression of many chaperone genes are increased in 3D growth conditions. This may be due to increased proteotoxic stress encountered by cells grown in spheroids. Future work will analyze the significance of chaperones and the heat shock response in 3D growth of ovarian cancer cells. Note: This abstract was not presented at the conference. Citation Format: Trillitye Lotito, Chase Powell, Christopher Menzie, Candice Aiosa, Feng Cheng, Sandy Westerheide. Expression analysis of 2D versus 3D culture growth in HEY ovarian cancer cells. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr B11.
Six-Month Angiographic Outcome After Successful Repeat Percutaneous Intervention for In-Stent Restenosis
Authors: Christophe Bauters, Jean-Luc Banos, Eric Van Belle, Eugène P. Mc Fadden, Jean-Marc Lablanche, Michel E. Bertrand
Journal: Circulation (1998)

Background —In-stent restenosis is an increasing clinical problem. Discordant results have been published regarding the risk of recurrent restenosis after repeat angioplasty for the treatment of in-stent restenosis. Methods and Results —One hundred three consecutive patients (107 vessels) underwent repeat percutaneous intervention for the treatment of in-stent restenosis and were entered in a prospective angiographic follow-up program. Repeat balloon angioplasty was performed at 93 lesions (87%) and additional stenting at 14 lesions (13%). The primary success rate was 98%. Six-month angiographic follow-up was performed in 85% of eligible patients. Restenosis was determined by quantitative angiography. Restenosis defined as a &gt;50% diameter stenosis at follow-up was observed at 22% of lesions. The rate of target-lesion revascularization at 6 months was 17%. Repeat intervention for diffuse in-stent restenosis and severe stenosis before repeat intervention were associated with significantly higher rates of recurrent restenosis. Conclusions —The overall restenosis rate after repeat intervention for in-stent restenosis is low. The subgroup of patients with diffuse and/or severe in-stent restenosis, however, is at higher risk of recurrent restenosis and may benefit from alternative therapeutic strategies.
Acute rhabdomyolysis as a complication of cytarabine chemotherapy for acute myeloid leukemia: Case report and review of literature
Authors: Cristina I. Truica, Stanley R. Frankel
Journal: American Journal of Hematology (2002)

Abstract Rhabdomyolysis is an unusual complication of chemotherapy that can lead to substantial morbidity through such complications as renal failure, infections, and disseminated intravascular coagulation. The syndrome has been described after treatment with cyclophosphamide, 5‐azacytidine, interleukin‐2, and interferon and after bone marrow transplantation. We report a patient with acute myeloid leukemia who developed fulminant rhabdomyolysis after treatment with a cytarabine‐containing regimen. The syndrome was complicated by acute renal failure requiring hemodyalisis, respiratory insufficiency, and pancreatitis. We suggest that the muscle damage might be related to the known ability of cytarabine to trigger the release of cytochrome c from the mitochondria, which could lead to uncoupling of the oxidative phosphorylation with subsequent depletion of ATP reserves at the skeletal muscle and rhabdomyolysis. Am. J. Hematol. 70:320–323, 2002. © 2002 Wiley‐Liss, Inc.
The Chronic Pain Syndrome: Misconceptions and Management
Authors: JAMES B. REULER
Journal: Annals of Internal Medicine (1980)

The management of chronic pain is a universal and vexing problem for physicians. Literature indicates that health care providers have a poor understanding of basic concepts relating to pain, which leads to frustration for the physician and inadequate relief for the patient. This paper addresses misconceptions about organic versus functional pain, discusses placebos and administration of narcotic analgesics, and outlines therapeutic alternatives. Emphasis is on distinguishing chronic pain of benign origin from that secondary to malignancy as an individual treatment plan is formulated.