Axillary Freckling as a Diagnostic Aid in Neurofibromatosis
Authors: FRANK W. CROWE
Journal: Annals of Internal Medicine (1964)

Brief Communication1 December 1964Axillary Freckling as a Diagnostic Aid in NeurofibromatosisFRANK W. CROWE, M.D., F.A.C.P.FRANK W. CROWE, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-6-1142 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough Smith's (1) original description of the disease in 1849 did not mention pigmentation, nor did von Recklinghausen (2) mention it in 1882, increased pigmentation in the form of cafe-au-lait spots has long been associated with multiple neurofibromatosis. The addition of the pigmentary changes to the primary complex of tumors may be credited to Marie and Bernard (3) and to Chauffard (4) in 1896. This pigment (5, 6), situated in and around the basal cell layer of the epidermis, is melanin. The melanocytes in these sites are more abundant than usual. At one time much importance was ascribed to the...References1. SMITH RW: A Treatise on the Pathology, Diagnosis and Treatment of Neuroma, 1849; reprinted in whole as An Atlas of Illustrations of Pathology, London, New Sydenham Society, 1898, p. 38. Google Scholar2. VON RECKLINGHAUSEN F: Über die Multiplen Fibrome der Haut und Ihre Bezeihung zu den Multiplen Neuromen. Festschrift für Rudolf Virchow, Hirschwald, Berlin, 1882. Google Scholar3. MARIEBERNARD PA: Neurofibromatose généralisée. Soc. Med. Hop., Paris 13: 200, 1896. Google Scholar4. CHAUFFARD MA: Dermato-fibromatose pigmentaire (ou neurofibromatose généralisée). Ibid., p. 777. Google Scholar5. CROWESCHULL FWWJ: Diagnostic importance of the cafe-au-lait spot in neurofibromatosis. Arch. Intern. Med. (Chicago) 91: 758, 1953. CrossrefGoogle Scholar6. CROWESCHULLNEEL FWWJJV: Clinical Pathological, and Genetic Study of Multiple Neurofibromatosis. Charles C Thomas, Springfield, Ill., 1956. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Portland, OregonFrom the Department of Dermatology, University of Oregon Medical School, Portland, Oregon.This study was supported in part by training grant 5 T1 AM 5300-03, U. S. Public Health Service, Bethesda, Md.This work was presented at the Pacific Northwest Regional Meeting of the American College of Physicians on February 15, 1963, at Portland, Ore., and at the Boise Valley Chapter, American College of Surgeons, on May 25, 1963, at Boise, Idaho.Requests for reprints should be addressed to Frank W. Crowe, M.D., 116 W. State St., Boise, Idaho 83702. 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