tbuckley/cabot-search huggingface dataset:
304Nuclear targeting apelin induces phenotypic transition of vascular smooth muscle cells
Authors: C Chaabane, C Brun, A Roatti, S Konig, Y Audigier, AJ Baertschi, ML Bochaton-Piallat
Journal: Cardiovascular Research (2014)

Background: Apelin, and its receptor APJ, are a peptidic system playing a crucial role in vascular diseases. However, the role of apelin in atherogenesis and smooth muscle cell (SMC) proliferation remains unclear. We isolated 2 distinct SMC phenotypes from porcine coronary artery: spindle-shaped (S) and rhomboid (R). Biological features of R-SMCs (i.e. enhanced proliferative and migratory activities as well as poor level of differentiation) explain their capacity to accumulate into the intima. S100A4 is a marker of R-SMCs in vitro and of intimal SMCs, both in pig and human. S100A4 is a Ca2+-binding protein that can also be secreted; it has extracellular functions probably via the receptor for advanced glycation end products (RAGE). Purpose: Investigate the effects of apelin on SMC phenotypic transition and S100A4 expression and release. Methods and Results: We observed that apelin was highly expressed in R-SMCs particularly in their nucleus. P-SORT software analysis of preproapelin sequence suggested that N-terminal truncated apelin may target the nucleus, and we confirmed this in SMCs by overexpression of mutated preproapelin-His-tag. Transfection of mutated preproapelin-His-tag encoding plasmid in differentiated S-SMCs induced a transition towards a R-phenotype associated with increased proliferative activity, downregulation of SMC differentiation markers (i.e. alpha-smooth muscle actin), and increased nuclear expression and release of S100A4. In contrast, transfection of S-SMCs with wild type preproapelin-His-tag encoding plasmid did not induce nuclear targeting of Apelin or S100A4, and did not change the S-phenotype. Stimulation of S-SMCs with PDGF-BB, known to induce a transition to the R-phenotype, yielded nuclear targeting of both apelin and S100A4. In vivo, Apelin was expressed in SMC nuclei of stent-induced intimal thickening while its expression in the media was mainly cytoplasmic. Conclusions: Our results suggest that nuclear targeting of apelin in SMCs acts on S100A4 expression and release, cell proliferation and differentiation. The pathophysiological consequences of this retargeting could be instrumental in the understanding of artherosclerosis.
NKp46 and DNAM-1 NK-cell receptors drive the response to human cytomegalovirus-infected myeloid dendritic cells overcoming viral immune evasion strategies
Authors: Giuliana Magri, Aura Muntasell, Neus Romo, Andrea Sáez-Borderías, Daniela Pende, Daniel E. Geraghty, Hartmut Hengel, Ana Angulo, Alessandro Moretta, Miguel López-Botet
Journal: Blood (2010)
Goodpasture's Syndrome and Exposure to Solvents
Authors: Gregory J. Beirne
Journal: JAMA (1972)

Beirne and Brennan 1 suggest a relationship between exposure to hydrocarbons and rapidly progressive crescentic glomerulonephritis associated with antibodies to glomerular basement membrane. Six of eight such patients interviewed had a history of prolonged heavy exposure to various hydrocarbon solvents preceding the onset of their disease. Five of the six patients also had pulmonary hemorrhage, thereby fulfilling the criteria for Goodpasture's syndrome. Three of the patients with Goodpasture's syndrome had almost identical jobs cleaning mechanical parts that required degreasing and paint-removing solvents.  The authors propose that at least in some cases the disease is caused by the toxic effects of inhaled volatile hydrocarbons. Chemical interaction with lung or kidney basement membrane is thought to provoke the immunological response that in turn perpetuates and intensifies the tissue injury.  While retrospective studies such as this can only suggest and never prove an etiological relationship, the theory proposed would perhaps explain why this
Phosphodiesterase Type 5 Is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility
Authors: Jayan Nagendran, Stephen L. Archer, Daniel Soliman, Vikram Gurtu, Rohit Moudgil, Alois Haromy, Chantal St. Aubin, Linda Webster, Ivan M. Rebeyka, David B. Ross, Peter E. Light, Jason R.B. Dyck, Evangelos D. Michelakis
Journal: Circulation (2007)

Background— Sildenafil was recently approved for the treatment of pulmonary arterial hypertension. The beneficial effects of phosphodiesterase type 5 (PDE5) inhibitors in pulmonary arterial hypertension are thought to result from relatively selective vasodilatory and antiproliferative effects on the pulmonary vasculature and, on the basis of early data showing lack of significant PDE5 expression in the normal heart, are thought to spare the myocardium. Methods and Results— We studied surgical specimens from 9 patients and show here for the first time that although PDE5 is not expressed in the myocardium of the normal human right ventricle (RV), mRNA and protein are markedly upregulated in hypertrophied RV (RVH) myocardium. PDE5 also is upregulated in rat RVH. PDE5 inhibition (with either MY-5445 or sildenafil) significantly increases contractility, measured in the perfused heart (modified Langendorff preparation) and isolated cardiomyocytes, in RVH but not normal RV. PDE5 inhibition leads to increases in both cGMP and cAMP in RVH but not normal RV. Protein kinase G activity is suppressed in RVH, explaining why the PDE5 inhibitor–induced increase in cGMP does not lead to inhibition of contractility. Rather, it leads to inhibition of the cGMP-sensitive PDE3, explaining the increase in cAMP and contractility. This is further supported by our findings that, in RVH protein kinase A, inhibition completely inhibits PDE5-induced inotropy, whereas protein kinase G inhibition does not. Conclusions— The ability of PDE5 inhibitors to increase RV inotropy and to decrease RV afterload without significantly affecting systemic hemodynamics makes them ideal for the treatment of diseases affecting the RV, including pulmonary arterial hypertension.
Re: Cursiefen et al.: Aganirsen antisense oligonucleotide eye drops inhibit keratitis-induced corneal neovascularization and reduce need for transplantation: the I-CAN study (Ophthalmology 2014;121:1683-92)
Authors: Eduardo M. Rocha, Luis Fernando Nominato, Peter S. Reinach
Journal: Ophthalmology (2015)
Risk Stratification for Noncardiac Surgery
Authors: Shaun D. Frost, Franklin A. Michota
Journal: Annals of Internal Medicine (2004)

Letters6 January 2004Risk Stratification for Noncardiac SurgeryShaun D. Frost, MD and Franklin A. Michota, MDShaun D. Frost, MDFrom The Cleveland Clinic Foundation, Cleveland, OH 44195.Search for more papers by this author and Franklin A. Michota, MDFrom The Cleveland Clinic Foundation, Cleveland, OH 44195.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-1-200401060-00037-w1 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Grayburn and Hillis (1) present a timely perspective on the role of noninvasive testing for cardiac risk stratification among patients undergoing noncardiac surgery. However, we believe it is premature to conclude that “the era of routine noninvasive testing has ended.” We agree that many patients with a score of 2 or less on the revised cardiac risk index (RCI) (2) receiving perioperative β-blockade represent a low-risk population among whom noninvasive cardiac testing probably adds no information. However, we disagree that all patients with an RCI of 3 receiving β-blockade are uniformly at acceptable risk and believe that ...References1. Grayburn PA, Hillis LD. Cardiac events in patients undergoing noncardiac surgery: shifting the paradigm from noninvasive risk stratification to therapy. Ann Intern Med. 2003;138:506-11. [PMID: 12639086] LinkGoogle Scholar2. Lee TH, Marcantonio ER, Mangione CM, Thomas EJ, Polanczyk CA, Cook EF, et al . Derivation and prospective validation of a simple index for prediction of cardiac risk of major noncardiac surgery. Circulation. 1999;100:1043-9. [PMID: 10477528] CrossrefMedlineGoogle Scholar3. Boersma E, Poldermans D, Bax JJ, Steyerberg EW, Thomson IR, Banga JD, et al . Predictors of cardiac events after major vascular surgery: role of clinical characteristics, dobutamine echocardiography, and β-blocker therapy. JAMA. 2001;285:1865-73. [PMID: 11308400] CrossrefMedlineGoogle Scholar4. Michota FA, Frost SD. Perioperative management of the hospitalized patient. Med Clin North Am. 2002;86:731-48. [PMID: 12365338] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From The Cleveland Clinic Foundation, Cleveland, OH 44195. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCardiac Events in Patients Undergoing Noncardiac Surgery: Shifting the Paradigm from Noninvasive Risk Stratification to Therapy Paul A. Grayburn and L David Hillis Risk Stratification for Noncardiac Surgery Steven L. Cohn Metrics 6 January 2004Volume 140, Issue 1Page: W-1KeywordsCardiac surgeryEchocardiographyForecastingIschemiaMyocardial infarctionPatient advocacy ePublished: 6 January 2004 Issue Published: 6 January 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
In vitro effects of pemphigus antibodies on skin
Authors: WALTER L. BINDER, ERNST H. BEUTNER, TADEUSZ P. CHORZELSKI
Journal: British Journal of Dermatology (1978)

Journal Article In vitro effects of pemphigus antibodies on skin Get access WALTER L. BINDER, WALTER L. BINDER Department of Microbiology, State University of New York at Buffalo, Buffalo, New York 14214, and Department of Dermatology, Warsaw Academy of Medicine, Warsaw, Poland Search for other works by this author on: Oxford Academic Google Scholar ERNST H. BEUTNER, ERNST H. BEUTNER Department of Microbiology, State University of New York at Buffalo, Buffalo, New York 14214, and Department of Dermatology, Warsaw Academy of Medicine, Warsaw, Poland Search for other works by this author on: Oxford Academic Google Scholar TADEUSZ P. CHORZELSKI TADEUSZ P. CHORZELSKI Department of Microbiology, State University of New York at Buffalo, Buffalo, New York 14214, and Department of Dermatology, Warsaw Academy of Medicine, Warsaw, Poland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 99, Issue 1, 1 July 1978, Pages 39–42, https://doi.org/10.1111/j.1365-2133.1978.tb01958.x Published: 01 July 1978
Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cells
Authors: Christian Becker, Christian Taube, Tobias Bopp, Christoph Becker, Kai Michel, Jan Kubach, Sebastian Reuter, Nina Dehzad, Markus F. Neurath, Kurt Reifenberg, Franz-Joseph Schneider, Edgar Schmitt, Helmut Jonuleit
Journal: Blood (2009)
CASE OF CHRONIC ULCERATIVE CHOLECYSTITIS WITHOUT GALLSTONES AND WITH NO SYMPTOMS REFERABLE TO THIS CONDITION.
Authors: JAMES P. TUTTLE
Journal: JAMA (1907)

toneal wound, the needles are then rethreaded and the shuttle stitch begun as when the catgut was used.The advantages of this stitch are:First.-The peritoneal edges are accurately everted.Second.-Only about one-half of the quantity of buried suture material is required.Third.-The fascial edges are everted and thus a broad surface for their union is coapted.Fourth.-One-half of the time is saved in suturing.Fifth.-The figure-of-eight snture, if desired, can be placed easily just before closing the skin wound.
Disturbances in Cardiac Conduction and their Management
Authors: JOHN MERIDETH, RAYMOND D. PRUITT
Journal: Circulation (1973)

A simple classification of atrioventricular block, criteria for diagnosis, and suggested therapy are discussed. The differences between Mobitz I and II second-degree A-V block are reviewed. Good management of patients who have bundle-branch or other forms of intraventricular block depends on informed judgment which includes consideration of (1) the effect of intraventricular conduction disturbances on the pumping action of the heart, and (2) the likelihood that a specific intraventricular conduction disturbance will be complicated by complete heart block. Evidence suggests that common forms of intraventricular disturbance, unlike ventricular fibrillation, do not alter significantly the pumping action of the heart. The role of intraventricular conduction disturbances in the genesis of ventricular fibrillation is assessed. We concluded that only when right bundle-branch block is combined with block of the anterior or posterior fascicle of the left bundle branch is complete heart block sufficiently imminent to warrant special concern. If bilateral block is associated with symptoms of episodic severe bradycardia, pacemaker therapy is indicated.
Electronic diaries for asthma
Authors: B. Tiplady, G K Crompton, D. Brackenridge
Journal: BMJ (1995)

EDITOR,—Hyland and coworkers have reported the successful use of hand held computers as electronic diary cards in asthma.1 Such devices greatly simplify data handling, and they record the time at which each entry was made. However, the use of a conventional type of computer may present problems for some patients. Pen based devices (Personal Digital Assistants, PDAs) provide an alternative that may be easier for many patients to use.

We have developed an electronic …
Lithium in Psychiatric Disorders
Authors: G. Silverman
Journal: BMJ (1968)

MEDIALIJOURNAL 271 and, though fresh heparinized blood is ideal, citrated blood can certainly be given for a limited number of exchanges.Plasmaphoresis has also been recommended," the patient's packed red cells being returned to him in fresh, frozen plasma from a donor, but in practice this may be more difficult to carry out than a simple exchange.But compared with extra- corporeal perfusion of patient's blood through a pig liver1 or cross-circulation with a human volunteer,'6 the other methods available for temporary liver support, it is a relatively simple procedure. Bacteriological Hazards of Beards"After many years of absence from the laboratory scene, beards are now being worn by some persons working with pathogenic micro-organisms."So say M. S. Barbeito and colleagues, of the Industrial Health and Safety Office, Fort Detrick,
Synch Before You Speak: Auditory Hallucinations in Schizophrenia
Authors: Judith M. Ford, Brian J. Roach, William O. Faustman, Daniel H. Mathalon
Journal: American Journal of Psychiatry (2007)

Objective: Synchronization of neural activity preceding self-generated actions may reflect the operation of the forward model, which acts to dampen sensations resulting from those actions. If this is true, pre-action synchrony should be related to subsequent sensory suppression. Deficits in this mechanism may be characteristic of schizophrenia and related to positive symptoms, such as auditory hallucinations. If so, schizophrenia patients should have reduced neural synchrony preceding movements, especially patients with severe hallucinations. Method: In 24 patients with schizophrenia or schizoaffective disorder and 25 healthy comparison subjects, the authors related prespeech neural synchrony to subsequent auditory cortical responsiveness to the spoken sound, compared prespeech neural synchrony in schizophrenia patients and healthy comparison subjects, and related prespeech neural synchrony to auditory hallucination severity in patients. To assess neural synchrony, phase coherence of single-trial EEG preceding talking was calculated at a single site across repeated trials. To assess auditory cortical suppression, the N1 event-related brain potentials to speech sound onset during talking and listening were compared. Results: In healthy comparison subjects, prespeech neural synchrony was related to subsequent suppression of responsiveness to the spoken sound, as reflected in reduction of N1 during talking relative to listening. There was greater prespeech synchrony in comparison subjects than in patients, especially those with severe auditory hallucinations. Conclusions: These data suggest that EEG synchrony preceding speech reflects the action of a forward model system, which dampens auditory responsiveness to self-generated speech and is deficient in patients who hallucinate.
To Err With Air
Authors: J. C. Weisman
Journal: JAMA (1964)

<h3>To the Editor:—</h3> Accolades to Dr. Homer V. Hartzell for his courageous communication, "To Err With Air," in the Feb 8 issue (<i>JAMA</i><b>187</b>:455). For a number of years I have been doing air contrast studies, since the informed clinicians and radiologists have assumed this was the ultimate refinement in x-ray diagnosis of colonic lesions. I have often felt inadequate because double shadows may appear like neoplastic lesions and air bubbles may appear like polyps. I believe that radiology would be better served by use of additional films for lateral, oblique, or the Lapine-Chassard position, which may unfold the sigmoid and demonstrate a hidden lesion in this "blind spot."
Basil Ian Franklin Eminson
Authors: M. G. C. Eminson
Journal: BMJ (2013)

<h3>Introduction</h3> In the relapsing remitting type of multiple sclerosis (MS) reducing relapses and neurodegeneration is crucial in halting the long-term impact of the disease. Medical disease-modifying treatments have proven effective, especially when introduced early in the disease course. However, patients still experience disease activity and disability progression, and therefore, supplemental early treatment strategies are warranted. Exercise appear to be one of the most promising supplemental treatment strategies, but a somewhat overlooked ‘window of opportunity’ exist early in the disease course. The objective of this study is to investigate exercise as a supplementary treatment strategy early in the disease course of MS. <h3>Methods and analysis</h3> The presented Early Multiple Sclerosis Exercise Study is a 48-week (plus 1-year follow-up) national multicentre single-blinded parallel group randomised controlled trial comparing two groups receiving usual care plus supervised high-intense exercise or plus health education (active control). Additionally, data will be compared with a population-based control group receiving usual care only obtained from the Danish MS Registry. The primary outcomes are annual relapse rate and MRI derived global brain atrophy. The secondary outcomes are disability progression, physical and cognitive function, MS-related symptoms, and exploratory MRI outcomes. All analyses will be performed as intention to treat. <h3>Ethics and dissemination</h3> The study is approved by The Central Denmark Region Committees on Health Research Ethics (1-10-72-388-17) and registered at the Danish Data Protection Agency (2016-051-000001 (706)). All study findings will be published in scientific peer-reviewed journals and presented at relevant scientific conferences. <h3>Trial registration number</h3> NCT03322761.
The clinical features, management and prognostic effects of pathological fractures in a multicenter series of 373 patients with diffuse large B-cell lymphoma of the bone
Authors: S. Govi, D. Christie, C. Messina, M. Bruno Ventre, E.A. Gracia Medina, D. Porter, J. Radford, D. Seog Heo, Y. Park, G. Martinelli, E. Taylor, H. Lucraft, V. Ballova, E. Zucca, M. Gospodarowicz, A.J.M. Ferreri
Journal: Annals of Oncology (2013)
1164-130 Chronotropic stress enhances the effects of asynchronous left ventricular activation on myocardial perfusion in patients with idiopathic dilated cardiomyopathy and left bundle branch block
Authors: Cecilia Marini, Jan Schneider-Eicke, Piero Salvadori, Gianmario Sambuceti, Antonio L'Abbate, Danilo Neglia
Journal: Journal of the American College of Cardiology (2004)
Does reduced erythrocyte C3b receptor (CR1) activity contribute to the pathogenesis of yersinia triggered reactive arthritis?
Authors: R Lahesmaa, E Eerola, A Toivanen
Journal: Annals of the Rheumatic Diseases (1992)

Erythrocyte C3b receptor (CR1) activity was measured in 27 patients with yersinia triggered reactive arthritis and in 151 control subjects, including 36 patients with uncomplicated yersiniosis and 115 healthy subjects. CR1 was measured by the immune adherence haemagglutination method. Patients with yersinia triggered reactive arthritis had reduced levels of CR1 compared with the controls. This difference was mainly due to the finding that five out of six HLA B27 negative patients with arthritis had decreased CR1 activity. Such a quantitative difference may contribute to the pathogenesis of reactive arthritis by affecting the clearance of immune complexes.
Residents and Patients: What Our Language Tells Us
Authors: Joshua Hauser
Journal: JAMA (1998)

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