Farmer's Lung
Authors: JOHN RANKIN
Journal: Annals of Internal Medicine (1962)

Article1 October 1962Farmer's LungPhysiopathologic Features of the Acute Interstitial Granulomatous Pneumonitis of Agricultural WorkersJOHN RANKIN, M.D., M.R.C.P., WALTER H. JAESCHKE, M.D., QUINTON C. CALLIES, B.S., HELEN A. DICKIE, M.D., F.A.C.P.JOHN RANKIN, M.D., M.R.C.P.Search for more papers by this author, WALTER H. JAESCHKE, M.D.Search for more papers by this author, QUINTON C. CALLIES, B.S.Search for more papers by this author, HELEN A. DICKIE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-4-606 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWe have previously described the clincal features of an acute granulomatous interstitial pneumonitis that occurred in 39 agricultural workers after exposure to moldy organic farm dusts (1). Thirty-four additional patients have been studied since 1958. The present report concerns the pathologic features demonstrated by lung biopsy and the close correlation of the histologic evidence with our concept of the pathologic physiology and natural history of the disease. Moreover, we now believe that a diagnosis can be established with certainty without the aid of lung biopsy and that, except in rare instances, we are no longer justified in subjecting the patient...References1. DICKIERANKIN HAJ: Farmer's lung. An acute granulomatous interstitial pneumonitis occurring in agricultural workers. JAMA 167: 1069, 1958. CrossrefMedlineGoogle Scholar2. DARLINGCOURNANDRICHARDS RCADW: Studies on intrapulmonary mixture of gases. III. An open circuit method for measuring residual air. J. Clin. Invest. 19: 609, 1940. CrossrefMedlineGoogle Scholar3. BALDWINCOURNANDRICHARDS EDADW: Pulmonary insufficiency. I. Physiological classification, clinical methods of analysis, standard values in normal subjects. Medicine 27: 243, 1948. CrossrefMedlineGoogle Scholar4. COMROEFOWLER JHWS: Lung function studies. VI. Detection of uneven alveolar ventilation during a single breath of oxygen. Amer. J. Med. 10: 408, 1951. CrossrefMedlineGoogle Scholar5. OGILVIEFORSTERBLAKEMOREMORTON CMREWSJW: A standardised breath holding technique for the clinical measurement of the diffusing capacity of the lung for carbon monoxide. J. Clin. Invest. 36: 1, 1957. CrossrefMedlineGoogle Scholar6. MARSHALLDUBOIS RAB: The measurement of the viscous resistance of the lung tissues in normal man. Clin. Sci. 15: 161, 1956. MedlineGoogle Scholar7. DELANEYSCHMIDTSTROEBEL LTHWCF: Silo-filler's disease. Proc. Mayo Clin. 31: 189, 1956. MedlineGoogle Scholar8. LOWRYSCHUMAN TLM: "Silo-filler's disease"—syndrome caused by nitrogen dioxide. JAMA 162: 153, 1956. CrossrefMedlineGoogle Scholar9. GRAYSON RR: Silage gas poisoning: nitrogen dioxide pneumonia, new disease in agricultural workers. Ann. Intern. Med. 45: 393, 1956. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN RANKIN, M.D., M.R.C.P.; WALTER H. JAESCHKE, M.D.; QUINTON C. CALLIES, B.S.; HELEN A. DICKIE, M.D., F.A.C.P.Affiliations: Madison, WisconsinFrom the Department of Medicine and Cardiopulmonary Laboratory, University of Wisconsin Medical School, Madison, Wisconsin.Presented at the Forty-first Annual Session of the American College of Physicians, San Francisco, California, April 6, 1960.This study was supported in part by the Research Committee of the Graduate School from funds supplied by the Wisconsin Alumni Research Foundation, by the Wisconsin Heart Association, and the National Heart Institute (United States Public Health Service grant E-3335).Requests for reprints should be addressed to John Rankin, M.D., Cardiopulmonary Research Laboratory, University Hospitals, 1300 University Avenue, Madison 6, Wisconsin. 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SCHLUETER, M.D., JORDAN N. FINK, M.D., ABE J. SOSMAN, M.D.Deep-Seated Mycotic Infections, Allergy to Fungi and MycotoxinsSequoiosisFarmer's lungPulmonary Granulomatoses Due to Inhaled Organic AntigensBagassosis: A Study of Pulmonary Function in 20 CasesHANS WEILL, M.D., HOWARD A. BUECHNER, M.D., F.A.C.P., ERNESTO GONZALEZ, M.D., STEPHEN J. HERBERT, M.D., EDSEL AUCOIN, M.D., MORTON M. ZISKIND, M.D., F.A.C.P.Farmer's Lung in Maryland Clinical, Microbiological, and Immunological StudiesJOSEPH E. JOHNSON III, M.D.Grundzüge einer historischen und geographischen PathologieRecent Advances in Research on Environmental Toxicology of the Agricultural OccupationsAgricultural Dusts and Diffuse Pulmonary FibrosisFarmer's Lung.Atlas of Occupational and Environmental DiseasesRelation of Air Pollution To DiseaseFarmer's lungSilo filler's disease 1 October 1962Volume 57, Issue 4Page: 606-626KeywordsBiopsyGraduate medical educationHeartLongitudinal studiesLungsMedical servicesNatural history of diseasePneumonitisResearch laboratoriesRural areas ePublished: 1 December 2008 Issue Published: 1 October 1962 PDF downloadLoading ...