tbuckley/cabot-search huggingface dataset:
Pre-Procedural Glucose Levels and the Risk for Contrast-Induced Acute Kidney Injury in Patients Undergoing Coronary Angiography
Authors: Joshua M. Stolker, Peter A. McCullough, Seshu Rao, Silvio E. Inzucchi, John A. Spertus, Thomas M. Maddox, Frederick A. Masoudi, Lan Xiao, Mikhail Kosiborod
Journal: Journal of the American College of Cardiology (2010)
Management of Breast Cancer: Radical Mastectomy
Authors: Thomas J. Anglem
Journal: JAMA (1974)

THE rejection of Dr. Crile's policies by most informed surgeons is not a consequence of uncertainty as to his precise meaning about local excision or "partial mastectomy." It is rather a consequence of wide recognition of the extensive and easily demonstrable bias introduced by favorable case selection for the simple procedures that characterize his reports. This has been amply demonstrated in our article. There are, however, some points in Crile's article that merit further discussion and rebuttal. Crile asks, "Is there increased risk in partial mastectomy?" He answers the question by citing a retrospective, randomized, matched-pair study that as originally reported consisted of two groups of 53 patients: one group was treated by partial mastectomy and the other by total mastectomy. The ten-year survival rate for the partial mastectomy patients was a meager 34.4%. The data for the total mastectomy patients are not given, but it is stated that
HMOs (For-Profit and Not-for-Profit) on the Move
Authors: John K. Iglehart
Journal: New England Journal of Medicine (1984)

The drive to transform the traditional method of delivering medical care through the creation of alternative modes, which usually feature some limitation on a patient's choice of physicians in return for comprehensive medical benefits provided at a fixed price, has moved forward at an accelerating pace over the past decade. Fueled by a strong federal commitment to this concept, growing support by private employers and labor unions, and the rising cost of conventional care, enrollment in such plans tripled during the decade, but the base was small — 3 million. Now, for a variety of reasons, the thrust to promote . . .
Treatment of Thyrotoxicosis with 2-Mercaptoimidazole
Authors: G. L. Foss
Journal: BMJ (1950)

ALOPECIA AREATA in his series of cases.Nail changes seen in alopecia are interesting and quite common: 13 out of the 24 totalis and universalis cases showed them, and three other cases with simple patches had them in a minor degree.Leuconychia was not included, as this is not uncommon in normal subjects.Nail changes fall into two groups: (1) longitutlinal striations with a serrated nail edge, and (2) the pitted nail not unlike that of psoriasis.Sabouraud (1936) described these changes and said that when they are present the prognosis is hopeless.
RELATIONSHIP BETWEEN MITRAL REGURITATION AND LEFT VENTRICULAR EJECTION FRACTION AND STROKE VOLUME AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Yuji Itabashi, Kentaro Shibayama, Hirotsugu Mihara, Javier Berdejo, Robert Siegel, Hasan Jilaihawi, Raj Makkar, Takahiro Shiota
Journal: Journal of the American College of Cardiology (2014)
Effect of Clonidine on Atrioventricular Conduction
Authors: Larry E. Kibler
Journal: JAMA (1977)

Clonidine hydrochloride may be a factor in producing a high-grade atrioventricular block. Therefore, careful follow-up with repeated ECG monitoring seems to be indicated when clonidine is given to a patient with suspected cardiac conduction disease, especially if the patient is concurrently receiving digitalis therapy. (<i>JAMA</i>238:1930-1932, 1977)
MEDICAL SOCIETY OF THE MISSOURI VALLEY
Authors: B. T. Quigley
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Style in Medical Writing
Authors: Mark M. Ravitch
Journal: JAMA (1967)

To the Editor:—  I am frequently charmed by your editorial comments on medical writing and style. I am therefore confident that you were unable to resist the temptation to leave untouched the statement ( 198 :1371,1966) which reads:  One of the large subcutaneous nodules overlying the right deltoid muscle was excised with the patient under local anesthesia and divided into four parts.  Hanging and quartering was abandoned several centuries ago, but vestiges seem to persist!
Abstract 12054: Unmet Need and Applicability of Transcatheter Mitral Valve Repair with MitraClip in Patients with Severe Symptomatic Mitral Regurgitation
Authors: Sachin S Goel, E Murat Tuzcu, Bhuvnesh Aggarwal, Navkaranbir Bajaj, Supriya Gupta, Kanhaiya Poddar, Mobolaji Ige, Hazem Bdair, Abed Anabtawi, Shiraz Rahim, Patrick L Whitlow, Brian Griffin, William J Stewart, Marc Gillinov, Nicholas Smedira, Benico Barzilai, Samir R Kapadia
Journal: Circulation (2012)

Background: Patients with severe symptomatic mitral regurgitation (MR) have poor outcome without mitral valve (MV) surgery. Transcatheter MV repair using MitraClip is emerging as an alternative opt...
The case of the sugar sweetened beverage tax
Authors: D. Kamerow
Journal: BMJ (2010)

<b>BACKGROUND AND PURPOSE:</b> After an initial series of basilar artery stent angioplasty indicated a high technical success rate and minimal morbidity, subsequent reports suggested significant procedural risks. We retrospectively reviewed our experience with basilar artery stent placement to assess complications and clinical outcomes. <b>MATERIALS AND METHODS:</b> Ten consecutive patients with symptomatic intracranial athero-occlusive disease underwent stent placement of the basilar artery at our institution (1999–2003). We collected clinical data by chart review and determined outcomes (modified Rankin Scale [mRS]) by telephone interview. Angiographic data were analyzed by 2 blinded investigators. Clinical and angiographic variables were tested for correlation with outcome and complications using the Pearson correlation test. <b>RESULTS:</b> Of 10 patients (mean follow-up time, 31 months), 4 patients suffered 6 ischemic complications that were immediate in 1, early delayed (&lt;2 weeks) in 4, and late delayed (&gt;2 weeks) in 1. Complications included basilar artery rupture in 1 patient, access site complications in 1 patient, and other non-neurologic complications in 5. Symptomatic restenosis occurred in 1 patient. Outcomes (mRS) were excellent (0–2) in 5 patients, good (3) in 4, and poor (4–6) in 1 patient, who died. Ischemic complications were associated with lesion lumen ≤0.5 mm and lesion angulation &gt;45° (<i>P</i> &lt; .05). Less favorable clinical outcomes were associated with few ischemic complications and the presence of fewer than 2 patent vertebral arteries (<i>P</i> &lt; .05). <b>CONCLUSIONS:</b> Despite a significant incidence of ischemic and nonischemic complications after basilar artery stent placement, most patients in this small series achieved freedom from vertebrobasilar ischemia and good to excellent clinical outcomes at late midterm follow-up (12–46 months). Ischemic complications usually had an early delayed presentation and procedural risks correlated with lesion characteristics.
Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease (CKD)
Authors: Sharon M. Moe, Martina Reslerova, Markus Ketteler, Kalisha O'Neill, Danxia Duan, Jacob Koczman, Ralf Westenfeld, Willi Jahnen-Dechent, Neal X. Chen
Journal: Kidney International (2005)
Experts Advise on Potassium Iodide Use
Authors: Brian Vastag
Journal: JAMA (2003)

WASHINGTON—As fears of nuclear terrorism rise along with apprehensions about conventional and biological attacks, some media outlets have recommended that residents of large US cities keep a supply of over-the-counter potassium iodide on hand. But such advice was called into question at a recent symposium here on the usefulness of the drug, sponsored by the American Thyroid Association and the American Association of Clinical Endocrinologists. Experts concluded that potassium iodide could indeed help prevent thyroid cancers after a nuclear blast or a nuclear reactor meltdown on the scale of Chernobyl or larger.
The Unifying Concept of Illness Behavior
Authors: Laura Sirri, Giovanni A. Fava, Nicoletta Sonino
Journal: Psychotherapy and Psychosomatics (2012)

The concept of illness behavior was introduced to indicate the ways in which given symptoms may be perceived, evaluated and acted upon at an individual level. Illness behavior may vary greatly according to illness-related, patient-related and doctor-related variables and their complex interactions. In the past decades, important lines of research have been concerned with illness perception, frequent attendance at medical facilities, health care-seeking behavior, treatment-seeking behavior, delay in seeking treatment, and treatment adherence. They have, however, mostly investigated single aspects separately. In this concise review, we suggest that the concept of illness behavior may provide a unifying framework and useful insights to observations and findings that would otherwise remain scattered and unrelated in the medical literature. The wide range of expressions of illness behavior is likely to affect the presentation of any disease and its identification, course and treatment. Assessing illness behavior and devising appropriate responses by health care providers may contribute to the improvement of final outcomes.
Two month target for cancer treatment is breached for third quarter
Authors: J. Wise
Journal: BMJ (2014)

NHS trusts in England have breached the 62 day wait target for cancer treatment for the third consecutive quarter, latest figures show.1 The operational standard specifies that 85% of patients should wait no more than 62 days to begin their first definitive treatment after an urgent referral by their GP for suspected cancer.

In the quarter from July to September 2014 a …
DRUG-RESISTANT TUBERCLE BACILLI
Authors: Aaron D. Chaves
Journal: JAMA (1962)

In a recently published communication, Cohen<sup>1</sup>calls attention to the disturbing problem of drug-resistant tubercle bacilli. This report and similar ones from widespread areas merit serious consideration but require critical analysis. The problem of drug-resistant tubercle bacilli may be examined from 2 aspects: (1) from the point of view of the reduction in therapeutic effectiveness of the drugs in an individual patient and (2) in terms of the epidemiological implications of the spread of drug-resistant organisms within a community. From the therapeutic point of view, there is general agreement that the demonstration of the emergence of streptomycin resistance in vitro correlates closely with the loss of drug effectiveness in the patient. This is probably true, also, for the secondary antituberculous drugs such as aminosalicylic acid, pyrazinamide, cycloserine, viomycin, kanamycin, and ethionamide. There are considerable differences of opinion concerning the<i>clinical</i>significance of isolating<i>isoniazid-resistant</i>strains of tubercle bacilli from
Correction: IgE, Not IgG
Authors: PETER H. SCHUR
Journal: Annals of Internal Medicine (1971)

Letters, Comments, and Corrections1 November 1971Correction: IgE, Not IgGPETER H. SCHUR, M.D.PETER H. SCHUR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-5-812_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the paper, "Rheumatoid Arthritis Associated with Eosinophilia," by Panush, Franco, and Schur (Ann Intern Med 75:199-205, 1971), on page 201, lines 19 and 20, the text reads:Serum IgG levels were not elevated in the five patients with rheumatoid arthritis and eosinophilia.The statement should have been:Serum IgE levels were not elevated in the five patients with rheumatoid arthritis and eosinophilia.We thank Dr. Tushar K. Sinha of the Veterans Administration Hospital, Indianapolis, Indiana, for calling this error to our attention.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine Harvard Medical School Robert B. Brigham Hospital Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1971Volume 75, Issue 5Page: 812-812KeywordsEosinophiliaRheumatoid arthritis ePublished: 1 December 2008 Issue Published: 1 November 1971 PDF downloadLoading ...
Eumycetoma due to Madurella mycetomatis acquired in Jamaica.
Authors: C.L. Fletcher, M.K. Moore, R.J. Hay
Journal: British Journal of Dermatology (2001)

We report a case of eumycetoma due to Madurella mycetomatis affecting the left dorsal forefoot in a 35‐year‐old woman. She had spent her childhood in Jamaica, and had been resident in the U.K. for 20 years prior to her presentation. She gave a highly suggestive history for a mycetoma, having observed the intermittent discharge of black grains from the lesion. The diagnosis was confirmed by histological and mycological analysis of the grains, and a magnetic resonance imaging scan excluded osteomyelitis. She has responded very favourably to treatment with itraconazole. Mycetomas due to M. mycetomatis have not previously been reported from Jamaica.
Effects of oral laxatives on colonic motor complexes in dogs.
Authors: M Karaus, S K Sarna, H V Ammon, M Wienbeck
Journal: Gut (1987)

The effect of oral laxatives on the organisation of colonic motor complexes was investigated in four conscious dogs. Six strain gauge transducers were implanted on the colon of each dog. After a control period of two to three hours, dogs were orally dosed with 1, 2, or 4 ml/kg of castor oil, or 0.5 g/kg magnesium citrate. Oral olive oil, 4 ml/kg, was used as control. The recording was continued for another 10 hours or until defecation occurred. Each dog showed spontaneous cyclic bursts of contractions (contractile states) at all recording sites during the control period. Contractile states migrating orad or caudad over at least half the length of the colon were called colonic migrating motor complexes (CMMC). Castor oil and magnesium citrate significantly increased the period of colonic motor complexes, but olive oil had no significant effect. None of the above substances changed the percentage of orad migrating motor complexes, as compared with the control values. Periods in which colonic motor activity was completely absent for at least 60 min over at least three consecutive recording sites occurred more frequently after all of the substances. The occurrence of these periods of inhibition, however, was not a consistent feature and there seemed to be no relationship between the occurrence of inhibitory periods and defecation during the recording period. The dogs defecated within 10 hours after administration of magnesium citrate, 1, 2, and 4 ml/kg of castor oil in 12.5, 25, 37.5, and 88.8% of experiments respectively, but never with olive oil. Defecation was generally accompanied by giant migrating contractions in the colon. We conclude that oral laxatives, magnesium citrate and castor oil have a profound effect on colonic motor complexes and colonic motor activity. The period of CMMC is significantly prolonged after their oral administration because of an increased number of non-migrating motor complexes or periods of inhibition of motor activity.
Association between durable response (DR) and overall survival (OS) in patients with unresected stage IIIb-IV melanoma treated with Talimogene Laherparepvec (T-VEC) in the Phase III OPTiM trial
Authors: Howard L Kaufman, Robert HI Andtbacka, Frances A Collichio, Michael Wolf, Ai Li, Mark Shilkrut, Igor Puzanov, Merrick Ross
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts T-VEC is an HSV-1-derived oncolytic immunotherapy designed to selectively replicate within tumors, produce GM-CSF and enhance systemic antitumor immune responses. In OPTiM ([NCT00769704][1]), a randomized Phase III trial of intralesional T-VEC vs subcutaneous GM-CSF for unresected
Fractional Cleansing of the Large Bowel with “Golytely” for Colonoscopic Preparation: A Controlled Trial
Authors: T. Rösch, M. Classen
Journal: Endoscopy (1987)

“Golytely”, a lavage solution for colonoscopic preparation, has been in clinical use since 1980. Patients usually drink all the fluid (4-6 I “Golytely”) the morning before colonoscopy. However, clinical observation shows that many, especially elderly, patients have difficulty tolerating these large volumes.
TCT-747 Efficacy and safety of intensified antiplatelet therapy on the basis of platelet reactivity testing in patients after percutaneous coronary intervention: Systematic review and meta-analysis
Authors: Daniel Aradi, András Komócsi, Matthew Price, Thomas Cuisset, Hasan Ari, Dobri Hazarbasanov, Dietmar Trenk, Dirk Sibbing, Marco Valgimigli, Laurent Bonello
Journal: Journal of the American College of Cardiology (2012)
Impact of maternal serum alpha-fetoprotein screening on antenatal diagnosis.
Authors: D J Brock
Journal: BMJ (1982)

An analysis has been made of indications for amniocentesis in the Edinburgh area from 1979 to 1981. About 5% of all mothers underwent the procedure. Among 2137 amniocenteses, 37% were performed on mothers 35 years old or more, and 30% on patients with raised serum alpha-fetoprotein. The total number of amniocenteses and the categories have been stable for the past three years. As a result of amniocentesis 104 pregnancies were terminated, 66 of which (63%) followed a raised maternal serum alpha-fetoprotein indication, while only 10 (9.6%) were in mothers aged 35 or more. There were a further 12 terminations based on raised serum alpha-fetoprotein but where no amniocentesis had been thought necessary. Even when figures for anencephaly are excluded from the analysis, maternal serum alpha-fetoprotein screening was responsible for detecting 35 out of 63 (56%) abnormal fetuses. This constitutes a strong case for the continuation of alpha-fetoprotein screening programmes.From an analysis of indications for amniocentesis in the Edinburgh area from 1979 to 1981 it is concluded that alpha-fetoprotein screening programs for detection of neural tube defects should be continued. Raised maternal serum alpha-fetoprotein levels accounted for 30% of the amniocenteses and for 63% of the resulting selective abortions. Previous studies have shown that alpha-fetoprotein screening is accepted in this area by over three quarters of pregnant women and has an 80% detection rate, a higher acceptance and detection rate than that of prenatal screening for Down's syndrome.
Adiponectin Regulates Bone Mass via Opposite Central and Peripheral Mechanisms through FoxO1
Authors: Daisuke Kajimura, Ha Won Lee, Kyle J. Riley, Emilio Arteaga-Solis, Mathieu Ferron, Bin Zhou, Christopher J. Clarke, Yusuf A. Hannun, Ronald A. DePinho, X. Edward Guo, J. John Mann, Gerard Karsenty
Journal: Cell Metabolism (2013)
Abstract 3124: Xenograft models for development of new drugs targeting fibroblast growth factor receptor (FGFR)
Authors: Lan Zhang, Juan Zhang, Qian Shi
Journal: Cancer Research (2014)

Abstract The fibroblast growth factor receptors (FGFR) are tyrosine kinases that are present in many types of endothelial and tumor cells. There are 4 different fibroblast growth factor receptors (FGFR) in the cell: FGFR1, FGFR2, FGFR3, and FGFR4. The activation of FGFR pathway plays an important role in tumor angiogenesis, tumor growth, survival, as well as migration. Mutation or amplification/overexpresion of FGFR has been found in several types of tumors, including breast cancer, bladder cancer, gastric cancer, prostate cancer, colon cancer, multiple myeloma, and non-small cell lung carcinoma. Therefore, targeting FGFRs represents an attractive strategy for development of new cancer therapeutics. However, the lack of suitable models hinders the progress of research on FGFR inhibitors. Here we successfully validated subcutaneous models in several cancer types, in which FGFR is mutant or amplified/overexpressed, such as breast cancer MDA-MB-134 (FGFR1 amplification), gastric cancer SNU-16 (FGFR2 amplification), endometrial cancer AN3CA (FGFR2 N549K/K310R mutation), bladder cancer RT-4 (FGFR3 overexpression) and RT-112 (FGFR3 overexpression), lung cancer NCI-H1581 (FGFR1 amplification), as well as human derived gastric cancer GA114 (FGFR2 amplification). In conclusion, the validated cell line derived (CDX) and patient derived xenograft models (PDX) in several cancer types provide valuable platforms for the development of new compounds targeting FGFRs. Citation Format: Lan Zhang, Juan Zhang, Qian Shi. Xenograft models for development of new drugs targeting fibroblast growth factor receptor (FGFR). [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3124. doi:10.1158/1538-7445.AM2014-3124
Some aspects of blood loss and fluid balance in paediatric adenotonsillectomy.
Authors: H. B. Holden, J. J. Maher
Journal: BMJ (1965)

* Guy's Hospital, London. Now Senior Registrar a.t Charing Cross Hospital, London, t Guy's Hospital, London. piece to the child until the insertion of the gag. All the patients were operated on by one surgeon (H. B. H.) and anaesthetized by one of us (J. J. M.). Note was made of any incidents during induction or operation, such as cyanosis, retching, or laryngospasm. Depth of anaesthesia was judged by the absence of protective reflexes, as well as the rate and
Development of Accurate Models for Individualized Prediction of Survival After Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma
Authors: Vitaly Margulis, Shahrokh F. Shariat, Yury Rapoport, Michael Rink, Daniel D. Sjoberg, Nizar M. Tannir, E. Jason Abel, Stephen H. Culp, Pheroze Tamboli, Christopher G. Wood
Journal: European Urology (2012)
F-18 FDG PET Imaging in Gastrointestinal Stromal Tumor
Authors: Madhusudhan P. Reddy, Praveen Reddy, David L. Lilien
Journal: Clinical Nuclear Medicine (2003)

Gastrointestinal stromal tumor (GIST) is the most frequent mesenchymal malignancy of the gastrointestinal tract. Liver and peritoneum are the most frequent metastatic sites. Surgery is the mainstay of treatment in patients with localized disease. Imatinib mesylate (Gleevec; Novartis Pharmaceuticals, East Hanover, NJ), an inhibitor of tyrosine kinase activity of KIT receptor, has been shown to be an effective treatment in metastatic or unresectable disease. Follow-up of patients treated with Gleevec is controversial. The authors present a case of GIST that showed near-total response with Gleevec on fluorodeoxyglucose positron emission tomography. They suggest positron emission tomography as a useful imaging modality for the monitoring of therapy response in GIST tumors treated with Gleevec.
Expression of the chemokine receptor CXCR1 in human glomerular diseases
Authors: S. Segerer, A. Henger, H. Schmid, M. Kretzler, D. Draganovici, U. Brandt, E. Noessner, P.J. Nelson, D. Kerjaschki, D. Schlöndorff, H. Regele
Journal: Kidney International (2006)