Hemoperfusion for Phenylbutazone Poisoning
Authors: WILLIAM G. BERLINGER
Journal: Annals of Internal Medicine (1982)

Brief Reports1 March 1982Hemoperfusion for Phenylbutazone PoisoningWILLIAM G. BERLINGER, M.D., REYNOLD SPECTOR, M.D., MICHAEL J. FLANIGAN, M.D., GEORGE F. JOHNSON, Ph.D., MICHAEL R. GROH, B.S.WILLIAM G. BERLINGER, M.D.Search for more papers by this author, REYNOLD SPECTOR, M.D.Search for more papers by this author, MICHAEL J. FLANIGAN, M.D.Search for more papers by this author, GEORGE F. JOHNSON, Ph.D.Search for more papers by this author, MICHAEL R. GROH, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-3-334 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn overdose with phenylbutazone causes a syndrome that may include seizures, coma, and metabolic acidosis (1). Serious tissue damage such as hepatic necrosis, renal failure, cardiovascular collapse, and death, may occur (1). We report a case of a comatose, hypotensive patient who had ingested at least 4 g of phenylbutazone. Because of the long half-life of phenylbutazone (approximately 3 days) and the potential for significant tissue damage, we treated this patient with hemoperfusion.A 37-year-old woman with rheumatoid arthritis was transferred from another hospital to the University of Iowa Hospital in a deep coma 36 hours after a massive ingestion of...References1. DUKES M, ed. Meyler's Side Effects of Drugs. 9th ed. Princeton N.J.: Excerpta Medica; 1980:142-45. Google Scholar2. MELMONMORELLI KH, eds. Clinical Pharmacology. 2nd Ed. New York: Macmillan Publishing Co., Inc.; 1978:25-109. Google Scholar3. WINCHESTERGELFANDTILSTONE JMW. Hemoperfusion in drug intoxication: clinical and laboratory aspects. Drug Metab Rev. 1978;8:69-104. CrossrefMedlineGoogle Scholar4. STRONGWILSONDOUGLASCOPPEL JJJD. Phenylbutazone self-poisoning treated by charcoal haemoperfusion. Anaesthesia. 1979;34: 1038-40. CrossrefMedlineGoogle Scholar5. BASELT R. Distribution of Toxic Drugs and Chemicals in Man. Vol. 2. Canton: Biomedical Publications; 1978:42-5. Google Scholar6. NEUVONENELONEN PE. Effect of activated charcoal on absorption and elimination of phenobarbitone, carbamazepine, and phenylbutazone in man. Eur J Clin Pharmacol. 1980;17:51-7. CrossrefMedlineGoogle Scholar7. AARBAKKE J. Clinical pharmacokinetics of phenylbutazone. Clin Pharmacokinet. 1978;3:369-80. CrossrefMedlineGoogle Scholar8. STECATKINSONNEVIN GAM. N-Acetylprocainamide pharmacokinetics in functionally anephric patients before and after perturbation by hemodialysis. Clin Pharmacol Ther. 1979;26:618-28. CrossrefMedlineGoogle Scholar9. GARELLALORCH SJ. Hemoperfusion for acute intoxications: con. Clin Toxicol. 1980;17:515-27. CrossrefMedlineGoogle Scholar10. BROWNLEE K. Statistical Theory and Methodology. New York: John Wiley and Sons, Inc.; 1965:349-51. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Iowa Hospitals Iowa City, Iowa PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPhenylbutazoneHemoperfusion for the Treatment of Poisoning: Technology, Determinants of Poison Clearance, and Application in Clinical PracticeNON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs)PhenylbutazoneThe hepatotoxicity of non-steroidal anti-inflammatory drugsPoisoning with equine phenylbutazone in a racetrack workerMethods to Increase Poison EliminationClinical Use of Class Ia Antiarrhythmic DrugsPhysical Assessment and Differential Diagnosis of the Poisoned PatientAcute Poisoning Due to Non-Steroidal Anti-Inflammatory DrugsClinical Features and Management of Analgesic PoisoningAcute phenylbutazone poisoning in a childAnti-inflammatory analgesics and drugs used in rheumatoid arthritis and goutDrugs and Liver Disease: A Tabular Compilation of Drugs and the Histopathological Changes That Can Occur in the Liver 1 March 1982Volume 96, Issue 3Page: 334-335KeywordsComaEpileptic seizuresHalf lifeHemoperfusionHospital medicineHospitalsIngestionNecrosisRenal failureRheumatoid arthritis Issue Published: 1 March 1982 PDF DownloadLoading ...