Transfusion-Transmitted Virus and Mixed Cryoglobulinemia
Authors: Patrice Cacoub
Journal: Annals of Internal Medicine (1999)

Letters2 March 1999Transfusion-Transmitted Virus and Mixed CryoglobulinemiaPatrice Cacoub, MD, Philippe Halfon, MD, and Lucile Musset, PhDPatrice Cacoub, MDHôpital La Pitié-Salpétrière; 75161 Paris Cedex 13, France (Cacoub)Hôpital La Pitié-Salpétrière; 75161 Paris Cedex 13, France (Halfon)Hôpital La Conception; Marseille, France (Musset)Search for more papers by this author, Philippe Halfon, MDHôpital La Pitié-Salpétrière; 75161 Paris Cedex 13, France (Cacoub)Hôpital La Pitié-Salpétrière; 75161 Paris Cedex 13, France (Halfon)Hôpital La Conception; Marseille, France (Musset)Search for more papers by this author, and Lucile Musset, PhDHôpital La Pitié-Salpétrière; 75161 Paris Cedex 13, France (Cacoub)Hôpital La Pitié-Salpétrière; 75161 Paris Cedex 13, France (Halfon)Hôpital La Conception; Marseille, France (Musset)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-5-199903020-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A newly discovered DNA virus, transfusion-transmitted virus (TTV), has been implicated in fulminant non-A, B, or C hepatitis and chronic liver disease of unknown cause (1, 2). This virus shares several characteristics with parvoviruses, such as a high buoyant density. A high prevalence of TTV in blood donors (1.9%) and blood products (factor VIII and factor IX concentrates) (44% to 56%) from the United Kingdom was recently reported (3).Mixed cryoglobulinemia is characterized by purpura, arthralgia, and asthenia associated with cryoglobulins composed of various immunoglobulins. Widespread vasculitis usually involves small and medium-sized vessels, particularly in the nervous ...References1. Nishizawa T, Okamoto H, Konishi K, Yoshizawa H, Miyakawa Y, Mayumi M. A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology. Biochem Biophys Res Commun. 1997;241:92-7. CrossrefMedlineGoogle Scholar2. Naoumov NV, Petrova EP, Thomas MG, Williams R. Presence of a newly described human DNA virus (TTV) in patients with liver disease. Lancet. 1998;352:195-7. CrossrefMedlineGoogle Scholar3. Simmonds P, Davidson F, Lycett C, Prescott LE, MacDonald DM, Ellender J, et al . Detection of a novel DNA virus (TTV) in blood donors and blood products. Lancet. 1998;352:191-4. CrossrefMedlineGoogle Scholar4. Gorevic PD, Kassab HJ, Levo Y, Kohn R, Meltzer M, Prose P, et al . Mixed cryoglobulinemia: clinical aspects and long-term follow-up of 40 patients. Am J Med. 1980;69:287-308. CrossrefMedlineGoogle Scholar5. Cacoub P, Fabiani FL, Musset L, Perrin M, Frangeul L, Léger JM, et al . Mixed cryoglobulinemia and hepatitis C virus. Am J Med. 1994;96:124-32. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Patrice Cacoub, MD; Philippe Halfon, MD; Lucile Musset, PhDAffiliations: Hôpital La Pitié-Salpétrière; 75161 Paris Cedex 13, France (Cacoub)Hôpital La Pitié-Salpétrière; 75161 Paris Cedex 13, France (Halfon)Hôpital La Conception; Marseille, France (Musset) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMolecular Properties, Biology, and Clinical Implications of TT Virus, a Recently Identified Widespread Infectious Agent of HumansPolyradiculonévrite inflammatoire chronique et virus de l'hépatite CCRYOGLOBULINEMIA 2 March 1999Volume 130, Issue 5Page: 451-452KeywordsHepatitis C virusHepatitis G virusImmunoblottingLiver diseasesMedical risk factorsNervous systemPathogensPolymerase chain reactionVasculitisViremia ePublished: 15 August 2000 Issue Published: 2 March 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...