Interaction of Ofloxacin and Warfarin
Authors: Anne M. Baciewicz
Journal: Annals of Internal Medicine (1993)

Letters15 December 1993Interaction of Ofloxacin and WarfarinAnne M. Baciewicz, MD, Bimal H. Ashar, MD, and Todd W. Locke, MDAnne M. Baciewicz, MD, Bimal H. Ashar, MD, and Todd W. Locke, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-12-199312150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We describe a patient receiving warfarin in whom prothrombin time, which was associated with gross hematuria, was significantly prolonged when ofloxacin was administered.A 73-year-old woman had a history of recurring urinary tract infections that were caused by a partial congenital duplication of the right collecting system; recurring deep vein thrombosis and pulmonary emboli; hypertension; and endometrial cancer. Drug therapy included verapamil (sustained-release), enalapril, hydrochlorothiazide-triamterene, amitriptyline, and warfarin (5 mg 6 days a week). The prothrombin time had ranged between 15 to 21 seconds (control, 12.1 seconds) over the past 3 years. On 14 July 1993, Escherichia ...References1. Leor J, Matetzki S. Ofloxacin and warfarin (Letter). Ann Intern Med. 1988; 109:761. Google Scholar2. Leor J, Levartowsky D, Sharon C. Interaction between nalidixic acid and warfarin (Letter). Ann Intern Med. 1987; 107:601. Google Scholar3. Mott FE, Murphy S, Hunt V. Ciprofloxacin and warfarin (Letter). Ann Intern Med. 1989; 111:542-3. Google Scholar4. Linville D, Emory C, Graves L. Ciprofloxacin and warfarin interaction (Letter). Am J Med. 1991; 90:765. Google Scholar5. Linville T, Matanin D. Norfloxacin and warfarin (Letter). Ann Intern Med. 1989; 110:751-2. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCoumarin anticoagulantsANTICOAGULANTS, THROMBOLYTIC AGENTS, AND ANTI-PLATELET DRUGSInteraction between Warfarin and Levofloxacin: Case SeriesCoumarin anticoagulantsThe safety of levofloxacin in elderly patients on warfarinIncrease in International Normalized Ratio After Smoking Cessation in a Patient Receiving WarfarinMoxifloxacin and Warfarin: Additional Evidence for a Clinically Relevant InteractionMoxifloxacin—Warfarin Interaction: A Series of Five Case ReportsThe interaction of moxifloxacin and warfarin in three elderly patientsEffect of Levofloxacin Coadministration on the International Normalized Ratios During Warfarin TherapyAdverse Drug Reactions Related to the Use of Fluoroquinolone AntimicrobialsLevofloxacin and Warfarin InteractionClinically Significant Interactions with Drugs Used in the Treatment of TuberculosisTolérance des quinolonesINTERACTIONS OF WARFARINLevofloxacin and Warfarin InteractionClinical PharmacologyManagement of Drug Interactions in Patients with HIVDrugs affecting blood coagulation and fibrinolysisWarfarin interaction 15 December 1993Volume 119, Issue 12Page: 1223KeywordsHematocritLung and intrathoracic tumorsProtein metabolismProthrombin timePulmonary hypertensionRed blood cellsSigns and symptomsUrineVitamin K Issue Published: 15 December 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...