tbuckley/cabot-search huggingface dataset:
Cytidine deaminase activity in synovial fluid of patients with rheumatoid arthritis: relation to lactoferrin, acidosis, and cartilage proteoglycan release.
Authors: B Mansson, P Geborek, T Saxne, S Bjornsson
Journal: Annals of the Rheumatic Diseases (1990)

It is claimed that cytidine deaminase activity reflects local granulocyte turnover or activity in the synovial fluid of patients with rheumatoid arthritis, but cytidine deaminase is not a granulocyte specific enzyme. Lactoferrin is a granulocyte specific protein that is released from the secondary granulae during activation. We measured cytidine deaminase activity and lactoferrin concentrations in 33 rheumatic synovial fluid samples. Cytidine deaminase activity and lactoferrin concentrations correlated closely, indicating that both analyses reflect similar events in the joint-that is, result in their release from granulocytes. Cytidine deaminase activity and granulocyte concentrations correlated less closely, suggesting that there are additional factors besides the cell number which contribute to this release. Joint acidosis may be one such factor, as pH and cytidine deaminase activity correlated inversely. There was no association with synovial fluid proteoglycan concentrations, a marker of cartilage degradation.
Beneficial effect of a combination of retinoids and longacting theophylline in the treatment of psoriasis vulgaris
Authors: F. Raynaud, P. Gerbaud, D. Evain-Brion
Journal: British Journal of Dermatology (1994)

Journal Article Beneficial effect of a combination of retinoids and longacting theophylline in the treatment of psoriasis vulgaris Get access F. Raynaud, F. Raynaud Laboratoire de Physiopathologie du Développement, CNRS URA 1337, Ecole Normale Supérieure, 75230 Paris, Cedex 05, France Search for other works by this author on: Oxford Academic Google Scholar P. Gerbaud, P. Gerbaud Laboratoire de Physiopathologie du Développement, CNRS URA 1337, Ecole Normale Supérieure, 75230 Paris, Cedex 05, France Search for other works by this author on: Oxford Academic Google Scholar D. Evain‐Brion D. Evain‐Brion Laboratoire de Physiopathologie du Développement, CNRS URA 1337, Ecole Normale Supérieure, 75230 Paris, Cedex 05, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 131, Issue 5, 1 November 1994, Pages 740–742, https://doi.org/10.1111/j.1365-2133.1994.tb05003.x Published: 01 November 1994
Have Online International Medical Journals Made Local Journals Obsolete?
Authors: David Ofori-Adjei, Gerd Antes, Prathap Tharyan, Elizabeth Slade, Pritpal S Tamber
Journal: PLoS Medicine (2006)

Background to the Debate All of the major international medical journals are now available both in print and online. Being online increases the potential for these journals to have a more global distribution. With the rise of these online international journals, what functions do local journals serve?.
Hyperlipidemia in streptozocin-diabetic hamsters as a model for human insulin-deficient diabetes: Comparison to streptozocin-diabetic rats
Authors: Tetsu Ebara, Tsutomu Hirano, John C.L. Mamo, Ryouichi Sakamaki, Seiichi Furukawa, Seishi Nagano, Terumi Takahashi
Journal: Metabolism (1994)
Larger numbers of CD4bright dendritic cells in donor bone marrow are associated with increased relapse after allogeneic bone marrow transplantation
Authors: Edmund K. Waller, Hilary Rosenthal, Terry W. Jones, Jennifer Peel, Sagar Lonial, Amelia Langston, Istvan Redei, Ingrid Jurickova, Michael W. Boyer
Journal: Blood (2001)
Heparan sulfate domains on cultured activated glomerular endothelial cells mediate leukocyte trafficking
Authors: A.L. Rops, M.J. van den Hoven, M.M. Baselmans, J.F. Lensen, T.J. Wijnhoven, L.P. van den Heuvel, T.H. van Kuppevelt, J.H. Berden, J. van der Vlag
Journal: Kidney International (2007)
ABNORMAL VASCULAR REACTIONS IN ATOPIC ECZEMA*
Authors: R. H. CHAMPION
Journal: British Journal of Dermatology (1963)

Journal Article ABNORMAL VASCULAR REACTIONS IN ATOPIC ECZEMA Get access R. H. CHAMPION, M.B., M.R.C.P. R. H. CHAMPION, M.B., M.R.C.P. Consulting Dermatologist, Addenbrooke's Hospital, Cambridge Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 75, Issue 1, 1 January 1963, Pages 12–15, https://doi.org/10.1111/j.1365-2133.1963.tb13526.x Published: 01 January 1963
The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin
Authors: Hilary A. Kenny, Swayamjot Kaur, Lisa M. Coussens, Ernst Lengyel
Journal: Journal of Clinical Investigation (2008)

Most patients (80%) with ovarian cancer (OvCa) present with metastatic disease. Attachment of OvCa cells to peritoneum and omentum represents the first rate-limiting step for metastatic spread. Therefore, identifying factors regulating cell attachment in the abdominal cavity is critical to the development of therapeutic agents. We show here that MMP-2 expression was upregulated in OvCa cells upon attachment to their microenvironment. Downregulation of MMP-2 mRNA or pharmacological inhibition of MMP-2 proteolytic function, in both human OvCa primary cells and cell lines, reduced attachment of OvCa cells to a 3D organotypic model of metastatic OvCa, full human omentum or peritoneum, and in vivo to mouse peritoneum and omentum. Absence of MMP-2 in the host did not alter OvCa adhesion, as determined utilizing mice harboring homozygous null mutations in either the Mmp2 or Mmp9 genes. Conversely, adhesion induced upregulation of MMP-2 mRNA in OvCa cells. MMP-2 inhibition in OvCa cells through pharmacological or antibody treatment prior to i.p. dissemination in nude mice significantly decreased tumor growth and metastasis and extended survival. MMP-2 enhanced peritoneal adhesion of OvCa cells through cleavage of ECM proteins fibronectin (FN) and vitronectin (Vn) into small fragments and increased binding of OvCa cells to these FN and Vn fragments and their receptors, α5β1 and αVβ3 integrin. These findings indicate that MMP-2 expressed by metastatic OvCa cells functionally regulates their attachment to peritoneal surfaces.
Kinetics and distribution of platelets in man
Authors: Min‐Fu Tsan
Journal: American Journal of Hematology (1984)

Abstract 51 Cr sodium‐chromate, though having been widely used in the last two decades for labeling platelets, suffers from several serious drawbacks, ie, low labeling efficiency, long physical half‐life, and low gamma photon yields. 111 In‐oxine and 111 In‐tropolone overcome these shortcomings and have the potential of precise determination of platelet kinetics as well as visualization and in vivo quantification of the temporal and spatial distribution of platelets in man. Computer analysis of platelet kinetics reveals that the multiple‐hit model fits the survival curve better than the linear or the exponential model. The multiple‐hit model provides not only the mean platelet survival time but also information on the initial recovery and the shape of the survival curve. The application of these techniques in normal and disease states should greatly enhance our understanding of the physiology and pathophysiology of platelets.
Peak expiration flow variations may reflect house‐dust‐mite exposure and patient
Authors: T. E. Hallas, J. Korsgaard
Journal: Allergy (1998)

Peak expiration flow records from patients allergic to house‐dust mites ( Dermatophagoides spp.) may show a characteristic variation from week to week due to the general life cycle of these mites in dwellings. This was demonstrated from the combined records of 10 patients recorded in their own homes, covering a period of 30 consecutive weeks and comprising 973 peak flows. The levels of house‐dust mites were predicted from published data for floor‐dust samples from Danish dwellings. Peak flow increased or decreased in accordance with weekly changes in the concentration of mites, rather than as an immediate reaction to the current concentration of live, active mites. A dose‐response relation was demonstrated. This suggests that the patients' peak flow variations might be linked to molting in mites. As such, peak flow measurements have a potential as a tool for the specific diagnosis of, monitoring of, and research in asthma caused by domestic mites.
± Nothing/A Heartbreaking Work of Staggering Genius
Authors: John Quin
Journal: BMJ (2001)

Paul Morley 

Faber and Faber, £11.99, pp 426

ISBN 0 571 17799 9

Dave Eggers

Picador, £14.99, pp 395

ISBN 0 330 48454 0

Rating: ![Graphic][1] ![Graphic][2] ![Graphic][3] ; ![Graphic][4] ![Graphic][5] ![Graphic][6] ![Graphic][7] 

You have only to watch the news to see the modern media's take on ordinary human tragedy. The media sweeten the distress and horror, turning it into entertainment. The modern talk show, an oily slick of self disclosure, shows no sign of disappearing from our televisions. With this in mind, how might …

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The JAK2 617V&gt;F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia vera
Authors: Sabrina Dupont, Aline Massé, Chloé James, Irène Teyssandier, Yann Lécluse, Frédéric Larbret, Valérie Ugo, Patrick Saulnier, Serge Koscielny, Jean Pierre Le Couédic, Nicole Casadevall, William Vainchenker, François Delhommeau
Journal: Blood (2007)
SURGICAL TREATMENT OF HEMORRHOIDS.
Authors: WM. F. METCALF
Journal: JAMA (1902)

I bring this subject before the Section on Diseases of Women because hemorrhoids so frequently accompany pathologic changes in the uterus and its adnexa. The gynecologist who does not treat the rectum can not get the best results. From the time of Samuel, when, as is recorded, the men of Ashdod, Gaza, Askelon, Gath and Ekron had emerods in their secret parts, and I know not how long before this period, the treatment of hemorrhoids has been of interest. In those ancient times the priests instructed the Phillistines to prepare five golden images of the emerods which "mar the land," place them in the ark of the Lord and return them as a trespass offering to the Israelites, from whom they had taken it. This they did and were accordingly healed. The same act on the part of the laity prevails to-day, with this difference, the golden images are given
Fasting plasma glucose is inadequate screening test for prediabetes in obese youth
Authors: B. Kermode-Scott
Journal: BMJ (2008)

A fasting plasma glucose is recommended by the American and Canadian Diabetes Associations (ADA and CDA) for screening obese young people for prediabetes, but a recent Canadian study says it is inadequate.

In this two year prospective longitudinal study, the researchers at McMaster University in Hamilton, Ontario, will examine the health consequences of obesity in young people and will determine the prevalence of glucose intolerance and metabolic syndrome based on recommended International Diabetes Federation criteria at baseline in obese children and adolescents. The researchers will also study any changes in glycaemic status while the children are enrolled in a weight management programme.

Two …
Good news, bad news, good news
Authors: H. T. Ricketts
Journal: JAMA (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PF-114, a potent and selective inhibitor of native and mutated BCR/ABL is active against Philadelphia chromosome-positive (Ph+) leukemias harboring the T315I mutation
Authors: A A Mian, A Rafiei, I Haberbosch, A Zeifman, I Titov, V Stroylov, A Metodieva, O Stroganov, F Novikov, B Brill, G Chilov, D Hoelzer, O G Ottmann, M Ruthardt
Journal: Leukemia (2014)
The microRNA miR-155 controls CD8+ T cell responses by regulating interferon signaling
Authors: Donald T Gracias, Erietta Stelekati, Jennifer L Hope, Alina C Boesteanu, Travis A Doering, Jillian Norton, Yvonne M Mueller, Joseph A Fraietta, E John Wherry, Martin Turner, Peter D Katsikis
Journal: Nature Immunology (2013)
Commentary: The basis of a more rational method of funding primary medical care?
Authors: A. Majeed
Journal: BMJ (1996)

significant (for example, rates of car ownership and tenure status) are also similar to those identified in other studies, when modelled correctly in a multilevel framework, there are far fewer significant area effects: reliance on "indices of deprivation" will inevitably be very crude because individual characteristics are so much more powerful predictors of consulting behaviour.The models described form a basis for estimating the demand for general practitioner services at the practice level.While the problems in using individual socioeconomic data would be substantial, it might be possible, by a combination of small area statistics, the sample of anonymised records, and age-sex registers, to provide a basis for an equitable distribution of resources in the primary as well as the secondary care sector.
Cellular and molecular biology of chloride secretion in the shark rectal gland: Regulation by adenosine receptors
Authors: John N. Forrest
Journal: Kidney International (1996)

The rectal gland of the dogfish shark (Squalus acanthias) is a sodium chloride secreting epithelial organ whose function was discovered in 1959 by Wendell Burger. The gland, composed of homogenous tubules of a single cell type, is an important model for secondary active chloride transport. Hormonal stimulation of chloride secretion in this system activates asymetrically arranged transport proteins (apical cAMP-activated CFTR-like Cl- channels, basolateral Na/K/2Cl cotransporters, Na/K-ATPase activity, and K+ channels). Five receptors, hormones, and membrane proteins of the shark rectal gland involved in chloride secretion have been cloned recently. Because the intact gland can be perfused via a single artery and vein, it has been possible to examine precisely the metabolic regulation of chloride transport by endogenous adenosine. Rectal gland cells have a high density of both stimulatory A2 type and inhibitory A1 type adenosine receptors. When stimulated by secretagogues, chloride secretion and venous adenosine concentrations increase in parallel, with chloride secretion increasing from approximately 150 to 2100 microEq/hr/g, and adenosine concentrations increasing from approximately 5 to approximately 890 nM. This work of ion transport is accompanied by a marked fall in intracellular ATP activity and a rise in both intracellular AMP and adenosine activity. Agents that prevent the interaction of endogenous adenosine with extracellular receptors significantly increase the chloride transport response to secretagogues. When chloride transport is inhibited by blocking the Na/K/2Cl cotransporter with bumetanide, both adenosine release and chloride secretion fall to basal values. We recently cloned a unique adenosine receptor subtype that is distinct from previously cloned mammalian adenosine receptors. Because of its highly specialized function, single cell type, and simple vascular system, the shark rectal gland is an ideal model system for examining the metabolic regulation of chloride secretion by adenosine receptors.
The legacy of the Philadelphia chromosome
Authors: Gary A. Koretzky
Journal: Journal of Clinical Investigation (2007)

The discovery of the Philadelphia chromosome as a hallmark of chronic myelogenous leukemia in 1960 by Peter Nowell provided evidence for a genetic link to cancer. As with most seminal scientific observations, the description of the Philadelphia chromosome posed many more questions than were answered. This Review series includes contributions from individuals who performed critical experiments addressing some of the most important of these questions, reflecting the nearly 50 years of work inspired by Nowell's initial finding. The legacy of the Philadelphia chromosome now serves as a paradigm for how basic science discoveries can lead to effective new approaches for the treatment of human disease.
Telephone Psychotherapy and Telephone Care Management for Primary Care Patients Starting Antidepressant Treatment
Authors: Gregory E. Simon, Evette J. Ludman, Steve Tutty, Belinda Operskalski, Michael Von Korff
Journal: JAMA (2004)

Both antidepressant medication and structured psychotherapy have been proven efficacious, but less than one third of people with depressive disorders receive effective levels of either treatment.To compare usual primary care for depression with 2 intervention programs: telephone care management and telephone care management plus telephone psychotherapy.Three-group randomized controlled trial with allocation concealment and blinded outcome assessment conducted between November 2000 and May 2002.A total of 600 patients beginning antidepressant treatment for depression were systematically sampled from 7 group-model primary care clinics; patients already receiving psychotherapy were excluded.Usual primary care; usual care plus a telephone care management program including at least 3 outreach calls, feedback to the treating physician, and care coordination; usual care plus care management integrated with a structured 8-session cognitive-behavioral psychotherapy program delivered by telephone.Blinded telephone interviews at 6 weeks, 3 months, and 6 months assessed depression severity (Hopkins Symptom Checklist Depression Scale and the Patient Health Questionnaire), patient-rated improvement, and satisfaction with treatment. Computerized administrative data examined use of antidepressant medication and outpatient visits.Treatment participation rates were 97% for telephone care management and 93% for telephone care management plus psychotherapy. Compared with usual care, the telephone psychotherapy intervention led to lower mean Hopkins Symptom Checklist Depression Scale depression scores (P =.02), a higher proportion of patients reporting that depression was "much improved" (80% vs 55%, P<.001), and a higher proportion of patients "very satisfied" with depression treatment (59% vs 29%, P<.001). The telephone care management program had smaller effects on patient-rated improvement (66% vs 55%, P =.04) and satisfaction (47% vs 29%, P =.001); effects on mean depression scores were not statistically significant.For primary care patients beginning antidepressant treatment, a telephone program integrating care management and structured cognitive-behavioral psychotherapy can significantly improve satisfaction and clinical outcomes. These findings suggest a new public health model of psychotherapy for depression including active outreach and vigorous efforts to improve access to and motivation for treatment.
What's in a Name?-Reply
Authors: Alan Blum
Journal: JAMA (1978)

My quibble over the new drug name "flumoxonide" is probably more piddling than pedantic. The aim was as much to pun as to puncture. I remain a proponent of the use of nonproprietary names, although I occasionally balk at writing "dioctyl sodium sulfosuccinate," and I confess to abbreviating "phenoxymethyl penicillin." It is a real challenge to resist the subliminal impulse to prescribe the catchier brand name. Consequently, regardless of the trademark name that the manufacturer chooses for it, I have to smile when I see "flumoxonide," because "flummox" (origin unknown) means "to confuse." Now, "moxcinonide," the other possibility, calls to mind that delicious New England concoction, Moxie, but it still sounds too much like "syanide." I would say that "flumethoxonide" would have been a safe, if not especially stirring, compromise. In any event, I am sure that writing a prescription for flumoxonide will always brighten my day.
Thyroxine should be tried in clinically hypothyroid but biochemically euthyroid patients
Authors: G. R B Skinner, R Thomas, M Taylor, M Sellarajah, S Bolt, S Krett, A Wright
Journal: BMJ (1997)

<h3>Purpose</h3> To determine the effect of topical brimonidine tartrate prophylaxis on intraocular pressure (IOP) spikes following intravitreal injection of antivascular endothelial growth factor (anti-VEGF) agents. <h3>Methods</h3> This is a randomised crossover trial of consecutive non-glaucomatous eyes receiving intravitreal anti-VEGF injections between December 2016 and July 2017. All eyes were randomly assigned to no prophylaxis or topical brimonidine tartrate 0.15 % administered 20 min prior to injection in one of two consecutive visits. Measurements of IOP were obtained immediately (T0), 10 min (T10) and 20 min (T20) after injection during the visits with and without prophylaxis. <h3>Results</h3> Among the 58 eyes of 55 patients (116 visits), the mean (SD) age was 74.3 (11.6), and 62% were female. The mean baseline IOP was 15.3 (2.3) mm Hg (range: 11–20). On average, the immediate postinjection IOP during the visit without prophylaxis was 41.6 (12) mm Hg (range: 17–81). Compared with no prophylaxis, the visit with preadministered topical brimonidine tartrate had a lower IOP at T0 (p&lt;0.001), T10 (p=0.001) and T20 (p=0.043), and a smaller proportion of eyes with IOP elevation of greater than 20 mm Hg from preinjection (p=0.002) and IOP greater than 50 mm Hg at T0 (p=0.036). Without prophylaxis, two eyes (two patients) had an IOP of greater than 70 mm Hg at T0 and thus underwent anterior chamber paracentesis. <h3>Conclusion</h3> Topical brimonidine tartrate prophylaxis for intravitreal injection of anti-VEGF agents effectively reduces IOP spikes in non-glaucomatous eyes and may be easily incorporated into ophthalmologists’ current practice. <h3>Trial registration number</h3> NCT03513172