tbuckley/cabot-search huggingface dataset:
Abstract 897: Thymidine kinase 1, a novel biomarker specific to the plasma membrane of cancerous cell lines
Authors: Daniel W. Sharp, Dagoberto Estevez, Robert A. Whitehurst, Melissa M. Alegre, Brit L. Germann, Joshua W. Foster, Richard A. Robison, Kim L. O'Neill
Journal: Cancer Research (2011)

Abstract Thymidine Kinase 1 (TK1), an important nucleotide salvage pathway enzyme, has been shown to be upregulated in most malignant cancers. Recent studies have shown that TK1 not only has diagnostic and prognostic potential, but could also be used as a molecular target for therapeutic treatments. Previous research from our lab has shown the expression of TK1 on the plasma membrane of lymphoma. This study provides further insight on the role of TK1 as a diagnostic target for several different tumor cell lines. This study analyzed the localization of TK1 in ten different cancer cell lines using flow cytometry (FCM). The lines studied were A375, a malignant melanoma, CAL27, a squamous cell carcinoma derived from tongue, MDA-MB-231, a breast adenocarcinoma, MDA-MB-435S, previously described as a ductal carcinoma, HT29, a colorectal adenocarcinoma, SW620, a colorectal adenocarcinoma, A549, a lung carcinoma, NCI-H460, a large cell lung carcinoma, DU 145, a prostrate carcinoma, and PC3, a prostate adenocarcinoma. FCM was carried out using a polyclonal antibody against human TK1 as the primary antibody and a FITC conjugated secondary antibody. A sample stained with only secondary antibody was used as a negative control for the experiment. Five replicates were analyzed for each cell line. TK1 was found to bind between 48% and 96%, depending on the cell line. Non-cancerous tonsil tissue and normal lymphocytes were used as controls, where TK1 surface binding was less than 20%. These data indicate the feasibility of TK1 as a possible molecular target for immunotherapy in many types of cancer. Further research is ongoing to determine specific immunotherapy treatment options, and to verify the expression of TK1 in other cancer cell lines. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 897. doi:10.1158/1538-7445.AM2011-897
Book Review Practical Gynecologic Surgery: Principles in practice By Mark E. Boyd. 257 pp., illustrated. Baltimore, Urban and Schwarzenberg, 1990. $59.50. Laser Surgery in Gynecology and Obstetrics Second edition. Edited by William R. Keye, Jr. 279 pp., illustrated. Chicago, Year Book, 1990. $74.95.
Authors: Stephen C. Rubin
Journal: New England Journal of Medicine (1990)
Initial forces of ventricular depolarization in the Wolff-Parkinson-White Syndrome. Analysis based upon localization of the accessory pathway by epicardial mapping.
Authors: A M Tonkin, G S Wagner, J J Gallagher, G D Cope, J Kasell, A G Wallace
Journal: Circulation (1975)

The epicardial activation sequence of 34 patients with the Wolff-Parkinson-White syndrome was determined. Epicardial pre-excitation occurred at a spectrum of sites over either the free wall of the left or right ventricle or in a paraseptal region, always adjacent to the atrioventricular rings. The site of pre-excitation was related to the spatial position of the 10 msec vector of the vectorcardiogram (VCG) in 15 patients and the 20 msec vector of the electrocardiogram (ECG) in 29 patients with a single accessory pathway. All patients whose 20 msec vector (ECG) was directed to the right had accessory pathways which caused epicardial breakthrough over the free wall of the left ventricle. When the 20 msec vector (ECG) was to the left and inferior, epicardial pre-excitation was over either the right ventricular free wall or in the region of the pulmonary outflow tract. Superior location of the initial forces, especially the 10 msec vector (VCG), strongly suggested the presence of a septal bypass tract. The polarity of the delta wave and maximum QRS forces in precordial lead V1 were discordant in a significant number of patients, pointing to probable shortcomings of a classification based upon the latter.
RESPONSE: Re: Dietary Fat, Calories, and Prostate Cancer Risk
Authors: M. C. Bosland
Journal: JNCI Journal of the National Cancer Institute (1999)

Bosland et al.(1) describe "findings . . .based on the Dunning R3327-H rat prostate carcinoma and on LNCaP cells transplanted into SCID [severe combined immunodeficient] mice.Although these are the only androgensensitive prostate cancer models generally available at present, they are probably not good models for localized prostate cancer.LNCaP cells were derived from a metastatic lesion and have an uncommon androgen receptor mutation, and the Dunning R3327-H tumor was developed from a large (advanced) prostate tumor that had caused serious disease in its human host . . .."I disagree.As reviewed (2), there are many human, androgen-sensitive prostate cancers that grow in immunodeficient mice.In 1990, Kleinman et al. presented the first of several reports from her laboratory [reviewed in (2)] that showed that many kinds of neoplastic cells are more tumorigenic when transplanted in Matrigel into immunodeficient mice.Following the lead of Kleinman et al. (3), in 1991, we [reviewed in (2)] reported the transplantation of prostate cancers in Matrigel into nude mice.The xenografts that became serially transplantable (2,4)-CWR21, CWR22, CWR31/91, and several strains of CWR22R-have been sent to more than 100 investigators and are "generally available at present"
Early mortality after surgical resection for lung cancer: an analysis of the English National Lung cancer audit
Authors: Helen A Powell, Laila J Tata, David R Baldwin, Rosamund A Stanley, Aamir Khakwani, Richard B Hubbard
Journal: Thorax (2013)

For appropriately staged non-small cell lung cancer (NSCLC) surgical resection can dramatically improve survival, but some may not be offered this treatment because of concerns about perioperative mortality.We used data from the National Lung Cancer Audit (NLCA) to determine the proportions of English patients who died within 30 and 90 days after surgery for NSCLC. We quantified the predictors of early postoperative death and using these results devised a score to predict risk of death within 90 days of surgery.We analysed data on 10 991 patients operated on between 2004 and 2010. Three per cent (334) of patients died within 30 days of their procedure and 5.9% (647) within 90 days. Age was strongly associated with early postoperative death (adjusted OR within 90 days for 80-84 years vs 70-74 years: 1.46, 95% CI 1.07 to 1.98); significant associations were also observed with performance status (PS) (adjusted OR within 90 days for PS 2 vs PS 0: 2.40, 95% CI 1.68 to 3.41), as well as lung function, stage and procedure type.Our results show that age is the most important predictor of death within both of these early postoperative periods. We used the data in the NLCA to develop a predictive score, based on an English population and specific to lung cancer surgery, which estimates risk of death within 90 days; this score should be tested in future cohorts.
Modalities for Tuberculosis Control: Surveillance vs Vaccination-Reply
Authors: Timothy F. Brewer
Journal: JAMA (1997)

In Reply.  —Our analysis evaluated the likelihood that current national control policies would reach previously set goals for the elimination of TB in the United States. Evaluation of control policies in particular risk groups, such as health workers, is a logical next step, but it was not the purpose of the current study.  The scenario 1 described by Drs Reichman and Mangura has been published as a letter to the editor in reference to earlier work 2 done by some of us. In our view, while BCG vaccination complicates surveillance, it does not preclude it. We believe BCG would be effective in preventing TB among health care workers, as discussed more fully in this earlier work 2 and correspondence. 3 Several decision analyses by others 4,5 have similarly concluded that BCG vaccination is a reasonable option for TB prevention among health care workers. Although important, the ability to undertake future surveillance is
Why Michael Couldn't Hit and Other Tales of the Neurology of Sports
Authors: Terrence Riley
Journal: JAMA (1996)

Harold Klawans keeps being more fun to read. His last book, Life, Death, and In Between , was an engaging and personal account of the lessons and humanity of neurological practice, but Why Michael Couldn't Hit is better written and more fun. Sports stories, especially about wellknown characters—let's face it, icons— like Michael Jordan, Muhammad Ali, Lou Gehrig, and Wilma Rudolph—are always appealing. Sports and athletes appeal to almost everybody. Inside stories, with curious tidbits that explain an athlete's competitive edge or unique vulnerabilities, are hard to resist. Klawans brings us a basketful, and they do not disappoint. A number of the famous athletes he discusses are less well known now, like Primo Carnera and a football player and patient Klawans calls First Half Jameson to maintain his privacy, but the cases are still alive and interesting.  For instance, a basketball player was able to overcome some problems of Tourette syndrome
Career structure: an impediment in academic medicine
Authors: R F Gledhill
Journal: BMJ (1981)

prevalence figures, from well populations and hospital clinics, which in turn are the result of self-selection, referral patterns, and the age composition of the screened population.The data emphasise that, with a trend towards less selection of women for screening, the pre- dictive power of a positive diaphanoscopic test would be lower and that for a negative test higher than in their series.One case appears to be missing from their results but it does not materially influence the outcome.
Hypercalcemia in Cutaneous Lymphosarcoma With Response to Methotrexate
Authors: William J. Dubé
Journal: JAMA (1968)

In a case of cutaneous lymphosarcoma and symptomatic hypercalcemia, there was no radiographic evidence of skeletal involvement. Both the hypercalcemia and the tumor growth were controlled by the use of continuous intravenously administered methotrexate. This antimetabolite is effective in the treatment of lymphosarcoma associated with hypercalcemia, and it may be useful in evaluating the mechanism of hypercalcemia associated with malignancy.
Cochrane review says telephone follow-up of heart failure patients is effective
Authors: J. Wise
Journal: BMJ (2012)

A Cochrane systematic review has concluded that patients with chronic heart failure are less likely to die a year after discharge if they are offered case management—intense monitoring usually involving telephone follow-up by a specialist nurse and home visits. Such patients are also less likely to be readmitted to hospital in the six months after discharge.1

Chronic heart failure is becoming increasingly common as the population ages and carries high risks of emergency hospitalisation and death. In 2000 around 1.9% of the total budget of the NHS was spent on patients with heart failure and most of this cost was incurred by …
"Playing God" as an Act of Hope
Authors: Michael T. Kovalchik
Journal: Annals of Internal Medicine (1992)

Letters15 December 1992"Playing God" as an Act of HopeMichael T. Kovalchik, MDMichael T. Kovalchik, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-12-1060 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Most of the letters written in response to Dr. LaCombe's "Playing God" (1) were analytical, as if reviewing a scientific manuscript. Few accepted this story for what it was, a piece of literature. Its purpose, through poetic license, was to evoke a response, piercing the armor of indifference to reveal the intense interior life of a physician.As I read the story of Kitty and Earl for the first time I was overcome by raw emotion. My response was similar to my children's when they eat a special treat, taking a few bites, then tucking it away...Reference1. LaCombe M. Playing God. Ann Intern Med. 1992;116:161-2. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Charlotte Hungerford Hospital 540 Litchfield Street Torrington, CT 06790 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1992Volume 117, Issue 12Page: 1060-1060KeywordsChildrenEmotions Issue Published: 15 December 1992 PDF downloadLoading ...
Laparoscopic and Histological Problems in the Diagnosis of Nodular Regenerative Hyperplasia of the Liver
Authors: J.A. Solis Herruzo, A. Duran, F. Colina, F. Santalla, J. Garcia-Cabezudo, M.T. Muñoz-Yagüe, J.D. Morillas
Journal: Endoscopy (1985)

We describe the laparoscopic findings in 5 patients with nodular regenerative hyperplasia of the liver (NRH). A nodular liver surface and signs of portal hypertension were observed, which in all cases gave rise to the laparoscopic diagnosis of liver cirrhosis. Multiple and single liver biopsies in 3 and 2 cases respectively, permitted the definitive diagnosis of the NRH lesion. The laparoscopic picture of NRH is indistinguishable from that of cirrhosis, and for this reason it is advisable to carry out liver biopsy even in cases where cirrhosis seems unquestionable.
A Randomized Cross-Over Study for Evaluation of the Effect of Image Optimization With Contrast on the Diagnostic Accuracy of Dobutamine Echocardiography in Coronary Artery Disease
Authors: Juan Carlos Plana, Issam A. Mikati, Hisham Dokainish, Nasser Lakkis, John Abukhalil, Robert Davis, Brian C. Hetzell, William A. Zoghbi
Journal: JACC. Cardiovascular imaging (2008)
Legal Issues in Scientific Research
Authors: Paul E Kalb, Kristin Graham Koehler
Journal: JAMA (2002)

In recent years, regulatory and law enforcement authorities responsible for combating fraud and abuse have focused greater attention on the scientific research process, in particular, the process of seeking reimbursement for research costs, the process of performing clinical research, and the potential improper remuneration of researchers or research subjects. This article describes how the federal False Claims Act, which allows the government to recover treble damages plus substantial penalties from persons who knowingly submit false claims or make false statements to the government, has been used to achieve a number of multimillion-dollar settlements with research institutions. The article also discusses instances of temporary suspension of research activities at a number of prominent institutions and the investigation of illegal "inducements" or "kickbacks" provided by manufacturers to researchers and by research institutions to patients.
Cytolytic activity against primary leukemic cells by inhibitory NK cell receptor (CD94/NKG2A)-expressing T cells expanded from various sources of blood mononuclear cells
Authors: J Tanaka, N Iwao, T Toubai, Y Tsutsumi, Y Miura, N Kato, A Shigematsu, M Yamane, S Ota, T Kondo, T Kobayashi, H Takeda, M Kobayashi, M Asaka, M Imamura
Journal: Leukemia (2004)
Cumulative dose response relationship of terbutaline delivered by three different inhalers
Authors: G. Fuglsang, S. Pedersen
Journal: Allergy (1988)

In a controlled, open cross‐over study 15 asthmatic children received increasing doses of terbutaline (0.125 mg + 0.125 mg + 0.25 mg + 0.5 mg + 0.I mg) delivered by a pressurized aerosol alone or with a tube spacer or a nebuhaler attached. At no time was there any significant difference in measured FEV 1 or percent increase in FEV 1 between the three inhalers. However, when eight patients with bronchodilation &gt; 50% on all tests days were studied separately, a significantly greater improvement in FEV 1 was seen after the first three inhalations of terbutaline when a nebuhaler or a tube spacer was used compared with the response after the pressurized aerosol ( P &lt; 0.05) Bronchodilation measurements did not differ after use of the two spacers. There was no statistically significant difference in side effects between the three inhalers, but there was a trend towards a higher occurrence of side effects when the pressurized aerosol was used alone.
First-aid Prophylactic Treatment of the Compression Syndrome ("Crush Syndrome")
Authors: D. H. Patey, J. D. Robertson
Journal: BMJ (1942)

The destruction of civilian property by air raids has been responsible for the recognition of a new clinical syndrome with characteristic features and often running a typical and fatal course.There is a history that the patient was in a building which collapsed after a bomb hit, and that a limb was pinned down by a beam or heavy object for several hours before release.Immediately on rescue the victim may look surprisingly well despite burial under debris for many hours.But some hours later the patient becomes gravely ill from shock, and, if this phase is successfully overcome, within 24 hours or so fresh anxiety arises owing to haematuria and a loW urinary output.Despite measures directed towards stimulating diuresis, the oliguria becomes progressively more marked,' terminating in anuria and death from uraemia.The limb that had been pinned down becomes very swollen and hard with oedema soon after its release from the pressure, and is partly or completely paralysed from nerve compression. Aetiology: A New ConceptionThis syndrome has been referred to as the " crush syndrome," perhaps incorrectly; for crushing and pulping of the tissues
Abstract 2728: Clonal nature of benign and malignant salivary gland neoplasms
Authors: Carolina Cavalieri Gomes, Claudia Maria Pereira, Joao Artur R Brito, Fabricio Rezende Amaral, Alvimar Afonso Barbosa, Luiz de Marco, Ricardo Santiago Gomez
Journal: Cancer Research (2011)

Abstract The pathogenesis of salivary gland neoplasms (SGN) has not been established. There is a real debate on clonality issues and all the definitive evidence is on the side of polyclonal tumor origin. Evidence that many tumor types may be polyclonal in origin has been published. Despite all this body of evidence, scientists have incorporated the clonal theory proposed by Knudson (1985) and only strengthen these results (and do not discuss contrary findings), because they think it is expected. There are few clonality studies on benign salivary neoplasms and almost no data on malignant neoplasms. The HUMARA assay was used in the present study to investigate the clonality of 27 samples of SGN (17 benign and ten malignant). Briefly, samples were digested with HhaI and HpaII methylation-sensitive enzymes and a PCR carried out. Eighteen out of 27 cases revealed monotypy, while three were non-informative and six showed heterotypy, indicating a true polyclonality. In summary, our results show evidence that a subset of SGN might be clonal in origin, while some samples are polyclonal. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2728. doi:10.1158/1538-7445.AM2011-2728
Use of computer program for diagnosing jaundice in district hospitals and specialized liver unit.
Authors: R B Stern, R P Knill-Jones, R Williams
Journal: BMJ (1975)

A computer-assisted model for diagnosing jaundice has been adapted for use on the University of London C.D.C. 7600 computer via an on-line terminal at King's College Hospital to provide a rapid turn-round time. The model was used prospectively in the diagnosis of 219 patients--135 seen in a specialized liver unit and 84 seen in one of four district hospitals in south-east London--with an overall accuracy in distinguishing among 11 different causes of jaundice of 69% and 62% respectively. These figures rose to 77% and 88% respectively when only those patients in whom the final diagnosis reached a "certain" probability were considered. When used to distinguish between a medical and a surgical cause of jaundice the accuracy was 86% in the liver unit and 77% in the district hospitals, rising to 95% in both series for those with a diagnosis of certain probability. The proposed improvements to the model--namely, the use of two deparate data bases and more diagnoses within the matrix--should be improve the accuracy even further. In practice the rapid feedback to the clinicians looking after patients provided help in managing difficult cases.
CHRONIC ULCERATIVE COLITIS
Authors: LOUIS A. BUIE
Journal: JAMA (1926)

By the term "chronic ulcerative colitis" I refer to a disease of the colon which has been variously named by different writers on the subject. Such men as Wilks and Moxon,<sup>1</sup>White,<sup>2</sup>Hawkins,<sup>3</sup>Jex-Blake,<sup>4</sup>Bassler,<sup>5</sup>Stone,<sup>6</sup>Yeomans,<sup>7</sup>Lynch and McFarland,<sup>8</sup>Logan<sup>9</sup>and Bargen<sup>10</sup>have evidently been dealing with the same disease under such names as idiopathic ulcerative colitis, nonspecific ulcerative colitis, asylum dysentery, innominate ulcerative colitis, and chronic ulcerative colitis. With the exception of Logan and Bargen in their more recent writings, they all agree that the discovery of any specific cause, such as the bacillus of tuberculosis, bacillus of Shiga, bacillus of Flexner, or<i>Endameba histolytica</i>, in connection with the disorder of the colon, rules out the so-called nonspecific type. Certain writers have thought that<i>Endameba histolytica</i>attacked the intestine and produced conditions that resulted in the development of