tbuckley/cabot-search huggingface dataset:
Effects of vasodilator therapy for severe pump failure in acute myocardial infarction on short-term and late prognosis.
Authors: K Chatterjee, H J Swan, V S Kaushik, G Jobin, P Magnusson, J S Forrester
Journal: Circulation (1976)

Forty-three patients with severe pump failure complicating acute myocardial infarction were treated with vasodilators (nitroprusside (40) and phentolamine (3)) for four hours to 27 days. Cardiac index, stroke volume index, and stroke work index (SWI) increased while the left ventricular filling pressure (LVFP) decreased during vasodilator therapy. Twenty-four of the 43 patients (56%) survived. Of patients with initial SWI between 11-20 gm-m/m2 and LVFP less than 15 mm Hg, 68% survived. In contrast only 18% of patients with SWI of 10 gm-m/m2 or less and LVFP greater than 15 mm Hg survived. Of the 17 patients with clinical shock, 8 (47%) survived. All 24 patients discharged from the hospital were followed for at least 12 months. Fourteen patients died one to 25 months (average 9.2 months) after discharge and the cause of death was pump failure in ten of them (71%). The ten survivors at last follow-up had been followed for 15 to 32 months (average 24 months). The cumulative survival at 24 months was 28%. Thus, despite improvement in short-term prognosis with vasodilator therapy in patients with severe pump failure complicating acute myocardial infarction, the prognosis for long term survival remains unfavorable, possibly due to severe intrinsic cardiac damage.
Acute and long-term safety of pressurized myocardial transvenous delivery: confirmation by biochemical, echocardiographic, and histologic parameters
Authors: Niall A. Herity, Bonnie L. Hiatt, William F. Fearon, Takeshi Suzuki, David J. McEneaney, Gerald Berry, Alan C. Yeung, Andrew J. Carter, Peter J. Fitzgerald, Paul G. Yock
Journal: Journal of the American College of Cardiology (2002)
A 20 month old girl with respiratory distress
Authors: D S Urquhart, S M Iqbal, J Bowman, S Suresh
Journal: BMJ (2009)

A previously well 20 month old girl presented to the emergency department with a history of fever and tachypnoea. She was accompanied by non-English speaking grandparents, and the available history was limited. She was tachycardic on arrival, with a heart rate of 168 beats a minute, as well as a raised respiratory rate of 52 breaths a minute. Widespread wheeze was audible, and she was given back to back bronchodilator therapy via a nebuliser.

She remained tachypnoeic (respiratory rate 38 breaths a minute), with increased air entry on the right side compared with the left. She was, however, free of wheeze. In view of the differential air entry, we undertook chest radiography (fig 1⇓).



Fig 1 Chest radiograph of 20 month old girl with respiratory distress





### Short answers



Fig 2 Chest radiograph of 20 …
Familial Pancreatic Cancer
Authors: MARTIN M. GRAJOWER
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 January 1983Familial Pancreatic CancerMARTIN M. GRAJOWER, M.D.MARTIN M. GRAJOWER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-1-111_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I write to add to the report of Dat and Sontag (1) with a brief description of another family with pancreatic carcinoma. I treated an 80-year-old white man who presented with jaundice and was found at surgery to have unresectable adenocarcinoma of the pancreas. The patient had two sisters, both of whom had died of pancreatic carcinoma, at age 69 and age 70, respectively. Both sisters had died by the time I saw the patient. Of further interest in this family was a history of colon cancer in another sister, and gastric carcinoma in the patient's mother....Reference1. DATSONTAG NS. Pancreatic carcinoma in brothers [Letter]. Ann Intern Med. 1982;97:282. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAetiology of pancreatic cancerCDKN2A Germline Mutations in Familial Pancreatic CancerFamiliäres PankreaskarzinomFamilial pancreatic cancerPancreatic adenocarcinoma: epidemiology and genetics.Familial pancreatic cancer in South LouisianaFamilial pancreatic adenocarcinoma in three generations. A case report and a review of the literaturePancreas 1 January 1983Volume 98, Issue 1Page: 111-111KeywordsAdenocarcinomaColorectal cancerPancreasPancreatic cancerSurgery Issue Published: 1 January 1983 PDF DownloadLoading ...
Current vital statistics: methods and interpretation.
Authors: A M Adelstein
Journal: BMJ (1978)

In the United Kingdom we are fortunate in having systems for medical statistics that in many respects are more comprehensive than those of other countries.Both the statistics and their use depend on their being accepted and promoted by the medical professions.Most national medical statistics are managed by the Office of Population Censuses and Surveys (OPCS).1One of the main functions of its medical statistics division is developing and exploiting statistical systems by which to analyse the changing state of health of the nation.In this paper I discuss some general principles and recent statistics. Decline in mortalityThe death rates for 1900-75 by generations (fig 1) declined con- sistently between successive five-year cohorts2 for ages up to about 40, with two exceptions.The first is during 1914-8 world war, when there was a severe influenza pandemic that struck mainly at young people.The second exception is that girls aged 15-19 in the latest cohort had a higher death rate than had the previous cohort-the result of in- creased deaths from accidents.
Cancer of the prostate gland. Results of early diagnosis and therapy undertaken for cure of the disease
Authors: V. A. Gilbertsen
Journal: JAMA (1971)

At the Cancer Detection Center at the University of Minnesota, 5,856 men underwent a total of 28,407 routine annual examinations, which included evaluation by digital palpation of the prostate gland. Seventy-five subsequently confirmed adenocarcinomas of the prostate gland were detected, and the patients with these had an absolute five-year survival rate of 77.3% (58). The absolute ten-year survival rate for 48 of these patients was 44%. Twenty-two patients who underwent curative total prostatectomies could be followed for a least five years. Twenty of the 22 were five-year survivors, for an absolute five-year survival rate of 91%; the age-adjusted rate was 100%. At ten years the absolute survival rate was 69%; and the relative survival rate was observed to have remained at 100%. These results may be compared with those of the End Results Study, which show relative survival rates of 49% at five years, and 29% at ten years.
Altering the distribution of Foxp3+ regulatory T cells results in tissue-specific inflammatory disease
Authors: Blythe D. Sather, Piper Treuting, Nikole Perdue, Mike Miazgowicz, Jason D. Fontenot, Alexander Y. Rudensky, Daniel J. Campbell
Journal: The Journal of Experimental Medicine (2007)

CD4+Foxp3+ regulatory T cells (T reg) are essential for maintaining self-tolerance, but their functional mechanisms and sites of action in vivo are poorly defined. We examined the homing receptor expression and tissue distribution of T reg cells in the steady state and determined whether altering their distribution by removal of a single chemokine receptor impairs their ability to maintain tissue-specific peripheral tolerance. We found that T reg cells are distributed throughout all nonlymphoid tissues tested, and are particularly prevalent in the skin, where they express a unique CCR4+CD103hi phenotype. T reg cell expression of CCR4 and CD103 is induced by antigen-driven activation within subcutaneous lymph nodes, and accumulation of T reg cells in the skin and lung airways is impaired in the absence of CCR4 expression. Mice with a complete loss of CCR4 in the T reg cell compartment develop lymphocytic infiltration and severe inflammatory disease in the skin and lungs, accompanied by peripheral lymphadenopathy and increased differentiation of skin-tropic CD4+Foxp3+ T cells. Thus, selectively altering T reg cell distribution in vivo leads to the development of tissue-specific inflammatory disease.
Porous acellular bovine pericardia seeded with mesenchymal stem cells as a patch to repair a myocardial defect in a syngeneic rat model
Authors: Hao-Ji Wei, Sung-Ching Chen, Yen Chang, Shiaw-Min Hwang, Wei-Wen Lin, Po-Hong Lai, Huihua Kenny Chiang, Lee-Feng Hsu, Hang-Hsing Yang, Hsing-Wen Sung
Journal: Biomaterials (2006)
Antibiotics in second trimester may reduce risk of preterm birth
Authors: Barbara Kermode-Scott
Journal: BMJ (2007)

Giving macrolides or clindamycin during the second trimester of pregnancy to women at risk of preterm births can lower the risk, a new systematic review and meta-analysis by Canadian researchers indicates. But the study also found that giving metronidazole alone in the second trimester is linked with a greater risk of preterm birth in the high risk population. 

The study's authors, from the University of Montreal and Laval University, Quebec, say that delivery before 37 weeks' gestation complicates between 7% and 11% of all pregnancies, is the leading cause of perinatal morbidity and mortality, and is …
Orthopedics: A History and Iconography
Authors: Jonathan Cohen
Journal: JAMA (1994)

Open this handsome book at random and you will have more than an even chance of encountering a portrait of an "icon" or picture of a patient, or of a device or diagram supplementing the text. The overall text is composed of many quotations (perhaps a third to a half of the space) and nutshell accounts of the achievements, demographics, and dates of each of the dramatis personae. So the text contains many, many names and dates. The question I raise is whether this is history or iconography, as asserted in the title. I say neither. Rather, it is a good source book, not to be read, but rather to be referred to for facts such as the chronology of any of the persons identified in the excellent index and bibliography, or a little bit of information about a figure of little renown. Before arguing whether this book deserves to
Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer
Authors: Lars A Forsberg, Chiara Rasi, Niklas Malmqvist, Hanna Davies, Saichand Pasupulati, Geeta Pakalapati, Johanna Sandgren, Teresita Diaz de Ståhl, Ammar Zaghlool, Vilmantas Giedraitis, Lars Lannfelt, Joannah Score, Nicholas C P Cross, Devin Absher, Eva Tiensuu Janson, Cecilia M Lindgren, Andrew P Morris, Erik Ingelsson, Lars Lind, Jan P Dumanski
Journal: Nature Genetics (2014)
Taste Dysfunction and Penicillamine
Authors: Sidney Lerner
Journal: JAMA (1976)

To the Editor.—  Loss of taste (hypalgeusia) secondary to zinc deficiency is discussed and substantiated in JAMA (235:88, 1976). It is also a frequently reported untoward effect during the administration of penicillamine for rheumatoid arthritis, scleroderma, and cystinuria. 1,2 The mechanism by which penicillamine produces this reaction remains unclear but, apparently, is not secondary to copper depletion. 3 Perhaps, the drug is causing the loss of significant amounts of essential zinc similar to that which occurs when other chelating agents are administered. 4 It is suggested that zinc levels in urine and serum be obtained before and during therapy with penicillamine. If marked reductions are seen, or hypalgeusia or other side effects develop, one may consider careful supplementation with zinc.
The Successful Medical School Department Chair: A Guide to Good Institutional Practices
Authors: N. S. Cherniack
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Katrina Survivors Strive to Reclaim Their Lives
Authors: Lynne Lamberg
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract C16: Mapping synthetic vulnerabilities in non-small cell lung cancer
Authors: Hyun Seok Kim, Saurabh Mendiratta, Jiyeon Kim, Chad Victor Pecot, Jill E. Larsen, Iryna Zubovych, Bo Yeun Seo, Jimi Kim, Banu Eskiocak, Hannah Chung, Elizabeth McMillan, Sherry Wu, Jef De Brabander, Kakajan Komurov, Bruce A. Posner, Rolf Brekken, Anil K. Sood, Ralph J. Deberardinis, Michael G. Roth, John D. Minna, Michael A. White
Journal: Cancer Research (2013)

Abstract Diversity in the genetic lesions that drive cancer initiation and progression is extreme. This diversity exists not only among tumors from different patients, but also among cancer cells within the same patient. This nefarious complexity is, in large measure, responsible for the capacity of this disease to evade current best efforts for effective therapy. “Personalized medicine” has been proposed in response to this conundrum as a mechanism to tailor cancer treatment to a specific tumor's genetic and epigenetic characteristics. However, selection of appropriate treatment is dramatically limited by the paucity of appropriate drugs and by the difficulty of linking treatment options to the appropriate patients. The challenge is to identify authentic intervention targets for development of an appropriately diverse cohort of therapies to contend with disease heterogeneity. We are addressing this challenge by a focused investigation of common vulnerabilities that arise as a consequence of oncogene expression and tumor evolution. Here we will describe a cancer intervention discovery pipeline using parallel genetic and chemical perturbations within an extensive panel of cell lines representative of the molecular lesions detected in lung cancer by national and international cancer genome sequencing efforts. We have found that current first line targeted therapies are discoverable within this panel together with the enrollment biomarkers required to stratify patient treatment regimens. Further, we have found that new genetic and chemical vulnerabilities can be revealed that are linked to recurrent mutations in lung cancer patients that are not currently “actionable”. We are leveraging this approach to stratify lung cancer subtypes and elaborate intervention targets that are linked to those subtypes by robust molecular discriminators. Note: This abstract was not presented at the conference. Citation Format: Hyun Seok Kim, Saurabh Mendiratta, Jiyeon Kim, Chad Victor Pecot, Jill E. Larsen, Iryna Zubovych, Bo Yeun Seo, Jimi Kim, Banu Eskiocak, Hannah Chung, Elizabeth McMillan, Sherry Wu, Jef De Brabander, Kakajan Komurov, Bruce A. Posner, Rolf Brekken, Anil K. Sood, Ralph J. Deberardinis, Michael G. Roth, John D. Minna, Michael A. White. Mapping synthetic vulnerabilities in non-small cell lung cancer. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr C16.
Pfizer asks journal for comments made by peer reviewers
Authors: Clare Dyer
Journal: BMJ (2008)

The multinational drug company Pfizer is trying to force leading medical journals to divulge the identities and comments of anonymous peer reviewers who judged articles submitted about two of the company’s painkillers.

Pfizer, which is facing a claim for damages by users of the cyclo-oxygenase-2 inhibitors celecoxib (Celebrex) and valdecoxib (Bextra), has issued subpoenas against journals including the New England Journal of Medicine , JAMA , the BMJ, and the Lancet .

Editors and researchers fear the move could threaten the confidentiality of the …
Calcium antagonists, nitrates, and new antianginal drugs.
Authors: D Maclean, J Feely
Journal: BMJ (1983)

In an attempt to assess some of the reactions of psychiatric outpatients attending a teaching clinic, a group of patients who received a letter warning them of the possible presence of students were compared with a group who did not receive such a letter. The “letter” group were generally more satisfied with their interview and were less likely to say that they had consciously withheld information. Greater satisfaction was also expressed by patients over 35. When asked whether they preferred to see one student in private and then the psychiatrist with a small group of other students, or to have the whole interview conducted by the psychiatrist in front of the group, patients expressed a clear preference for the former choice. This former method may also allow more responsible and active participation by the students.
P-31 nuclear magnetic resonance spectroscopic study of obstructive uropathy in the rat.
Authors: J I Shapiro, L Chan
Journal: Journal of Clinical Investigation (1987)

P-31 nuclear magnetic resonance (NMR) spectroscopy of the rat kidney with ureteral ligation resulted in a rapid and major increase in a peak resonating at 7096.63 +/- 0.65 Hz from the reference frequency of phosphorus (32.60 MHz). This corresponded to an increase in the concentration of the substance responsible for peak X from 0.34 +/- 0.04 mumol/g wet weight in normal kidneys to 1.45 +/- 0.27 mumol/g wet weight in unilaterally obstructed kidneys and 2.00 +/- 0.34 mumol/g wet weight in bilaterally obstructed kidneys at 3 h (P less than 0.01). Further NMR studies performed with in vivo kidneys and tissue extracts revealed that inorganic phosphate in the urine, resonating at a lower frequency due to the acid pH environment, was responsible for the increase in this peak. These findings may prove to be of fundamental interest as well as potential clinical significance.
Prescription Blanks for Narcotics
Authors: Robert Rapp
Journal: JAMA (1974)

To the Editor.—  Dr. Karakashian's comments on physician's narcotic prescription blanks (226:1572, 1973) bring to mind a system allowing the institutional control of prescription blanks for schedule II drugs only, implemented at the University of Kentucky hospital.  Under the system, to each legally eligible physician wishing to prescribe schedule II drugs is issued (by the pharmacy department) a pad of 25 consecutively numbered prescription blanks. Records are kept on a control card in the pharmacy. The physician writes all prescriptions for schedule II drugs on the assigned blanks. It is the responsibility of the physician to report to the pharmacy any lost blanks.  In addition, all of the hospital's routine prescription blanks distributed throughout the hospital bear the following statement, Caution— This prescription is invalid if used for schedule II controlled drugs.  All pharmacies in the central Kentucky area have been informed of this system and have been most cooperative
Health Care in the 2008 Presidential Primaries
Authors: Robert J. Blendon, Drew E. Altman, Claudia Deane, John M. Benson, Mollyann Brodie, Tami Buhr
Journal: New England Journal of Medicine (2008)

In this report of voters' views, respondents listed health care as an important issue in the 2008 presidential primary election. Democratic voters reported dissatisfaction with the health care system and favored government efforts to expand coverage for the uninsured. Republican voters were less dissatisfied and were less likely to favor increased government involvement in health care.
Long-lasting disease stabilization in the absence of toxicity in metastatic lung cancer patients vaccinated with an HLA-A2-restricted epitope derived from indoleamine 2,3 dioxygenase
Authors: Trine Z Iversen, Lotte Engell-Noerregaard, Eva Ellebaek, Rikke Andersen, Stine K Larsen, Jon Bjoern, Claus Zeyher, Cécile Gouttefangeas, Birte M Thomsen, Bente Holm, Per Straten, Anders Mellemgaard, Mads H Andersen, Inge M Svane
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts To investigate targeting of indoleamine 2.3 dioxygenase (IDO) enzyme using a synthetic peptide vaccine administered to patients with metastatic non small-cell lung cancer (NSCLC). In a clinical phase I study we treated 15 HLA-A2 positive patients with stage III-IV NSCLC in