tbuckley/cabot-search huggingface dataset:
Six minute walking test for assessing exercise capacity in chronic heart failure.
Authors: D P Lipkin, A J Scriven, T Crake, P A Poole-Wilson
Journal: BMJ (1986)

Twenty six patients, mean age 58 years (range 36-68), with stable chronic heart failure, New York Heart Association class II-III, and 10 normal subjects of a similar age range were studied. Exercise capacity was assessed by determining oxygen consumption reached during a maximal treadmill exercise test and by measuring the distance each patient walked in six minutes. There were significant differences in the distance walked in six minutes between normal subjects, patients with heart failure, class II, and those with class III heart failure (683 m, 558 m, and 402 m, respectively (p less than 0.003)). The relation between maximal oxygen consumption and the distance walked in six minutes was curvilinear; thus the distance walked varied considerably in those with a low maximal oxygen consumption but varied little in patients and normal subjects with a high maximal oxygen consumption. All subjects preferred performing the six minute walking test to the treadmill exercise test, considering it to be more closely related to their daily physical activity. The six minute test is a simple objective guide to disability in patients with chronic heart failure and could be of particular value in assessing patients with severe heart failure but less useful in assessing patients with mild heart failure.
Thiazide- and Phthalimidine-Induced Hyperglycemia in Hypertensive Patients
Authors: Nathan H. Carliner
Journal: JAMA (1965)

The hyperglycemic responses to trichlormethiazide (4 or 8 mg daily) and chlorthalidone (50 or 100 mg daily) for eight weeks were evaluated in 27 hypertensive patients. Twelve patients were diabetic, seven prediabetic, and eight nondiabetic. There was a significant increase in the two-hour blood sugar after an oral glucose load in all three groups. The fasting blood sugar increased significantly by the first week of treatment in the diabetics and by the last week of treatment in the prediabetics, but there was no significant change in the nondiabetics. Alterations of the fasting and two-hour blood sugar were not dependent on drug or dose. Serum potassium, sodium, amylase, and uric acid were measured and showed no correlation with the changes in the two-hour blood sugar. Permanent diabetes was not induced in any of the nondiabetic or prediabetic patients.
Androgenic steroid effects on liver and red cells.
Authors: M Alén
Journal: British Journal of Sports Medicine (1985)

Haematological and hepatic effects of testosterone/anabolic steroid self-administration were investigated in five power athletes during 26 weeks of training. During steroid administration blood haematocrit had increased 9.6% (p less than .05) in the study group (n = 5), but not in the control group (n = 6). This erythropoietic phenomenon was supported by increased (p less than .05) RBC and unchanged MCV. Blood haemoglobin concentration did not change markedly and consequently MCHC level in the study group decreased significantly (p less than .001). Also the erythrocyte sedimentation rate decreased (p less than .05) in the study group. The mean values of serum alanine aminotransferase, alkaline phosphatase and gamma-glutamyltransferase were and remained within normal range in both groups, although those of the study group were higher. The mean values of serum aspartate aminotransferase exceeded the normal range (56 U/l, at highest) but this may be of muscular rather than hepatic origin because of the severe training. It can be concluded that erythropoiesis was stimulated and liver function mildly impaired due to sustained high-dose testosterone/anabolic steroid administration.
Addition of cladribine to daunorubicin and cytarabine increases complete remission rate after a single course of induction treatment in acute myeloid leukemia. Multicenter, phase III study
Authors: J Holowiecki, S Grosicki, T Robak, S Kyrcz-Krzemien, S Giebel, A Hellmann, A Skotnicki, W W Jedrzejczak, L Konopka, K Kuliczkowski, B Zdziarska, A Dmoszynska, B Marianska, A Pluta, K Zawilska, M Komarnicki, J Kloczko, K Sulek, O Haus, B Stella-Holowiecka, W Baran, B Jakubas, M Paluszewska, A Wierzbowska, M Kielbinski, K Jagoda
Journal: Leukemia (2004)
Revisiting nephrogenic systemic fibrosis in 6 kidney transplant recipients: A single-center experience
Authors: Anne A. Lemy, Véronique del Marmol, Athanassios Kolivras, Whitney A. High, Celso Matos, Marianne Laporte, Joëlle L. Nortier
Journal: Journal of the American Academy of Dermatology (2010)
VDUP1 Is Required for the Development of Natural Killer Cells
Authors: Kee Nyung Lee, Hyung-Sik Kang, Jun-Ho Jeon, Eun-Mi Kim, Suk-Ran Yoon, Hyunkeun Song, Chil-Youl Lyu, Zheng-Hao Piao, Sun-Uk Kim, Ying-Hao Han, Su-Sung Song, Young-Ho Lee, Kyu-Sang Song, Yong-Man Kim, Dae-Yeul Yu, Inpyo Choi
Journal: Immunity (2005)
IS THERE AN IMMUNOLOGICAL RELATIONSHIP BETWEEN HORSE SERUM AND HORSE DANDER?
Authors: George F. Forster
Journal: The Journal of Experimental Medicine (1928)

Evidence has been submitted of the existence of a common antigenic substance in horse dander and horse serum. This evidence has been derived from three lines of study: (a) Cross-precipitation tests involving (1) the titration of antisera against horse serum with saline extract of horse dander and (2) titration of antisera against horse dander with normal horse serum. (b) Cross-anaphylactic tests by the uterine strip method of Dale. (c) Cross-anaphylactic tests in living guinea pigs by the usual shock method. It seems likely from the work here described that the common antigen is present in small proportion in horse dander. Its concentration in horse serum is not indicated by the results obtained.
Disseminated Herpes Simplex Virus Infection in Pregnancy
Authors: David C. Lagrew
Journal: JAMA (1984)

HERPES simplex virus (HSV or<i>Herpes virus hominis</i>) has recently gained public attention because of the epidemic of genital infection caused by serotype 2 (HSV-2). Herpetic vulvovaginitis in term pregnancy is a serious problem because of the risk of viral transmission to the neonate. However, reports of disseminated HSV infection in pregnant women are rare.<sup>1-7</sup> The early diagnosis of HSV infections has become important because effective treatment is frequently available. In the following case report, the patient had characteristics of disseminated HSV infection closely resembling those described in reports of fatal cases. Fortunately, our patient recovered with no apparent sequelae after treatment with intravenous (IV) acyclovir. <h3>Report of a Case</h3> A 26-year-old female, gradiva 2, para 1, had an estimated confinement date of Feb 28, 1983. On Dec 30, 1982, a temperature of 39 °C, malaise, a sore throat, and myalgia developed. The next day a chest roentgenogram showed diffuse bilateral
Costosternal Hernia Through Foramen of Morgagni
Authors: Pablo Nankin
Journal: JAMA (1971)

<h3>To the Editor.—</h3> Herniation through the foramen of Morgagni is uncommon, comprising only 2.5% of all diaphragmatic hernias. Harrington<sup>1</sup>reported 534 cases of diaphragmatic hernias and encountered only 14 of the costosternal type. This paper illustrates an unusual presentation of a Morgagni hernia as a pyloric obstruction in an elderly man. <h3>Report of a Case.—</h3> An 82-year-old white man was admitted to Oak Forest Hospital for treatment of right hemiparesis. His past history revealed peptic ulcer treated medically in 1940, and a left cerebral thrombosis in 1967 which caused the hemiparesis. While in the hospital for physiotherapy, with improvement of the hemiparesis, he started vomiting food and gastric mucus postprandially. Nasogastric decompression for 48 hours was followed by an x-ray film series of the upper gastro-intestinal tract, which showed a pyloric obstruction and elevation of the right diaphragm (Fig 1). Roentgenograms of the chest revealed elevation of the right
A NEW SKIAGRAPHIC TABLE AND TUBE HOLDER.
Authors: M. K. KASSABIAN
Journal: JAMA (1906)

This tube holder consists of a frame suspended from the ceiling. By this arrangement the undesirable vibrations caused either by the patient or the operator are prevented. The patient can get on the table easily. The tube holder slides to and fro to any part of the table, and also is capable of lateral movements, this being accomplished by the operator pulling on a cord as is seen in the illustration. Likewise the tube holder can be made to approach or to recede from the operator, and at the same time is capable of up and down and a rotary movement. The tube holder is scaled in centimeters and inches, as is also the frame. A ventral tube is attached in series with the Crookes' tube. When the skiagrapher desires to lower the vacuum in the ventral tube he compresses a bulb at a distance from the tube, which forces
Comparison of the Use of a Physiologically Based Pharmacokinetic Model and a Classical Pharmacokinetic Model for Dioxin Exposure Assessments
Authors: Claude Emond, Joel E. Michalek, Linda S. Birnbaum, Michael J. DeVito
Journal: Environmental Health Perspectives (2005)

In epidemiologic studies, exposure assessments of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) assume a fixed elimination rate. Recent data suggest a dose-dependent elimination rate for TCDD. A physiologically based pharmacokinetic (PBPK) model, which uses a body-burden-dependent elimination rate, was developed previously in rodents to describe the pharmacokinetics of TCDD and has been extrapolated to human exposure for this study. Optimizations were performed using data from a random selection of veterans from the Ranch Hand cohort and data from a human volunteer who was exposed to TCDD. Assessment of this PBPK model used additional data from the Ranch Hand cohort and a clinical report of two women exposed to TCDD. This PBPK model suggests that previous exposure assessments may have significantly underestimated peak blood concentrations, resulting in potential exposure misclassifications. Application of a PBPK model that incorporates an inducible elimination of TCDD may improve the exposure assessments in epidemiologic studies of TCDD.
The Hot-Cold Theory of Disease
Authors: Alan Harwood
Journal: JAMA (1971)

Many Puerto Ricans classify illnesses, medicines, and foods according to an etiological and therapeutic system which derives historically from Hippocratic humoral theories of disease. Adherence to this system influences the way in which patients comply not only with therapeutic regimens for hypertension, arthritis, ulcers, and rheumatic fever but also with instructions on infant feeding, and antepartum and postpartum care. To achieve maximum therapeutic benefit for Puerto Rican patients who adhere to this system, the physician is advised to work within its framework in prescribing medicines and diet.
Various factors (allergen nature, mouse strain, CpG/recombinant protein expressed) influence the immune response elicited by genetic immunization
Authors: J. M. Chatel, L. Song, B. Bhogal, F. M. Orson
Journal: Allergy (2003)

Background: Genetic immunization is a very promising therapeutic approach for allergy treatment. In the present study we investigate the influence of the nature of the allergen, the mouse strain, and the relative amount of CpG to expressed recombinant protein on immune responses using two major peanut allergens, Ara h 1 and Ara h 4. Methods: The cDNA of Ara h 1 and of an isoform of Ara h 4 were cloned and inserted in pcDNA3. Antigen specific IgG1, IgG2a and IgE were followed after genetic immunization with 100 μ g of these clones in mouse strain SKH‐Hr1 or BALB/c and with 1 μ g of the clones+99 blank plasmid in SKH‐Hr1. Results: Genetic immunization in SKH‐Hr1 with Ara h 1 elicited a classical Th1 type response, but Ara h 4 elicited a mixed Th1/Th2 response with high IgG1 and even IgE in some mice. In BALB/c both plasmids produced a high IgG1 level. Decreasing the amount of plasmid injected did not change the immune response profile. However, increasing the amount of CpG administered relative to the recombinant Ara h 4 protein expressed reversed the Th1/Th2 response pattern in SKH‐Hr1 mice. Conclusions: Immune responses after genetic immunization are strongly influenced by the nature of the allergen, the mouse strain, and the ratio of CpG to recombinant protein expressed.
A Note on Porro's Operation and a Suggested Modification
Authors: W. H. Horrocks
Journal: BMJ (1904)

<h3>Background</h3> There are large inequalities in levels of physical activity in the UK, and this is an important determinant of health inequalities. Little is known about the effectiveness of community-wide interventions to increase physical activity and whether effects differ by socioeconomic group. <h3>Methods</h3> We conducted interrupted time series and difference-in-differences analyses using local administrative data and a large national survey to investigate the impact of an intervention providing universal free access to leisure facilities alongside outreach and marketing activities in a deprived local authority area in the northwest of England. Outcomes included attendances at swimming and gym sessions, self-reported participation in gym and swim activity and any physical activity. <h3>Results</h3> The intervention was associated with a 64% increase in attendances at swimming and gym sessions (relative risk 1.64, 95% CI 1.43 to 1.89, P&lt;0.001), an additional 3.9% of the population participating in at least 30 min of moderate-intensity gym or swim sessions during the previous four weeks (95% CI 3.6 to 4.1) and an additional 1.9% of the population participating in any sport or active recreation of at least moderate intensity for at least 30 min on at least 12 days out of the last four weeks (95% CI 1.7 to 2.1). The effect on gym and swim activity and overall levels of participation in physical activity was significantly greater for the more disadvantaged socioeconomic group. <h3>Conclusions</h3> The study suggests that removing user charges from leisure facilities in combination with outreach and marketing activities can increase overall population levels of physical activity while reducing inequalities.
113. Manipulating AAV2 Tropism for Enhanced Delivery of AAV Vectors to the Spinal Cord
Authors: Adam Davis, Matthew Stachler, Wenfang Shi, James Liu, Nicholas Boulis, Jeffrey Bartlett
Journal: Molecular Therapy (2005)

Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressing neurodegenerative disorder. Currently, the pathway of motoneuron degeneration, caused by ALS, is poorly characterized and has severely limited the development of viable treatment options. Although gene therapy may provide a novel approach for developing effective treatments for ALS the need to deliver therapeutic genes throughout the CNS will require highly efficient and selective gene vector systems. On the basis of its extremely efficient uptake and delivery to motor neurons, we have attempted to develop tetanus toxin as a targeting ligand for neurospecific binding of AAV vectors with the goal of increasing the efficiency of retrograde transport and spinal cord delivery of AAV vectors.
The Iron Lung
Authors: Philip A. Drinker
Journal: JAMA (1986)

IT IS almost hard to recall now the enormous concern inspired by polio only a few decades ago. The most feared outcome of this disease was paralysis of the respiratory muscles that rapidly led to death from anoxia. Polio in the 1920s affected mostly children. It was geographically a very spotty disease, confined to a few blocks and then skipping large areas only to show up in clusters in other parts of town. Epidemics occurred every two or three years, and the percentage of "bulbar" polio varied from one epidemic to another but usually was low. True bulbar polio affected the brain stem and primarily the ability to swallow. These patients usually drowned in their own secretions but often could breathe well. However, patients who had "anterior" polio involving the cervical and thoracic spinal cord were unable to breathe at all. For the disease to be really serious, the spinal
On Needless Words
Authors: Stephen E. Goldfinger
Journal: New England Journal of Medicine (2005)

The presentation began. She described a 62-year-old male with a UGIB whose history included CAD S/P CABG x 2, NAFLD, DM, HT, PUD, and BPH. I looked around as the barrage mounted. Four residents and two students were right on track. Clearly, I was the only one struggling to assimilate the letter collage into a portrayal of a sick person, past and present. As I grappled with whether the penultimate “ED” referred to erectile dysfunction or emergency department, a sudden awareness of a hero I'd never met invaded my psyche and displaced all else. How pleased William Strunk, author of . . .
A British Hospital for Stalingrad
Authors: W. Cantuar, J. H. Hertz, D. L. George, A. J. Cummings, K. Atholl, J. Tanner, None Lytton, F. G. Hopkins, W. Lawther, R. W. MacRobert, None Horder, M. Murray, C. Haslett
Journal: BMJ (1943)
Medicine and the Holocaust
Authors: Jeremiah M. Gelles
Journal: Annals of Internal Medicine (1995)

Letters15 December 1995Medicine and the HolocaustJeremiah M. Gelles, MDJeremiah M. Gelles, MDBrooklyn, NY 11215Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-12-199512150-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Lerner and Rothman [1] present a pollyannaish view in their editorial on the attack on Jewish staff at the Medical Faculty of Vienna [2]. They state that “the record of the U.S. medical profession is, on the whole, commendable” [1]. I believe that the U.S. medical profession has been permeated by racism and that the education of U.S. physicians as we know it could not continue in the absence of this racism.The number of minority medical students has remained far below their percentage of the U.S. population, especially if the two predominantly black medical schools are ...References1. Lerner BH, Rothman DJ. Medicine and the Holocaust: learning more of the lessons [Editorial]. Ann Intern Med. 1995;122:793-4. LinkGoogle Scholar2. Ernst E. A leading medical school seriously damaged: Vienna 1938. Ann Intern Med. 1995;122:789-92. LinkGoogle Scholar3. Caldwell SH, Popenoe B. Perceptions and misperceptions of skin color. Ann Intern Med. 1995;122:614-7. LinkGoogle Scholar4. Kuhl S. The Nazi Connection. New York: Oxford University Pr; 1994. Google Scholar5. Fraser S, ed. The Bell Curve Wars. New York: Basic Books; 1995. Google Scholar Author, Article, and Disclosure InformationAffiliations: Brooklyn, NY 11215 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe nuremberg medical trial: Have we learned the lessons? 15 December 1995Volume 123, Issue 12Page: 964KeywordsGenetic diseasesHomicideMedical educationMolecular biologyRacial and ethnic issues Issue Published: 15 December 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
"The Mosquito Theory in Text-Books."
Authors: J. H. MUSSER
Journal: JAMA (1905)

Philadelphia, Oct. 16, 1905. <h3>To the Editor:</h3> —The criticism of Dr. MeCaw [The Journal, Oct. 7, 1905, p. 1100] is correct, and I am very much obliged to him for calling my attention to an obvious oversight, which escaped me in the revision, owing to the pressure of many duties. I wish also to thank Major Kean, surgeon, U. S. A., for noting the error to me simultaneously. The profession has been good enough to call for a new printing, which is in progress, and I have taken this opportunity to make the necessary correction.
The Carcinoid Syndrome
Authors: John A. Oates
Journal: New England Journal of Medicine (1986)

The carcinoid syndrome is an endocrine manifestation of neoplastic enterochromaffin cells. The humoral consequences of enterochromaffin carcinoid tumors include cutaneous flushing, diarrhea, valvular lesions of the right side of the heart, bronchoconstriction, and facial telangiectasia. Because these malignant tumors grow at a relatively slow rate, the morbidity during much of the illness they cause derives from their endocrine effects, including cardiac valvular lesions, which contribute substantially to mortality. Therefore, at a time when chemotherapy of these cancers is frequently unsuccessful, therapeutic measures that address their endocrine manifestations are realistic.The typical carcinoid tumors that arise from the gastrointestinal tract cause . . .
In the Witness Box — Still Waiting for the Doctor — A Disappointing Mermaid
Authors: John Lister
Journal: New England Journal of Medicine (1958)

ONE of the exhausting features of modern life is the surfeit of meetings, conferences and discussions of various kinds in which we all seem to become involved. A pleasant variant is the informal meeting of the local medical society, especially when it takes the form of a friendly chat over dinner and the guest speaker is entertained at a modest meal with just enough wine to make him fully at his ease by the time he is called to his feet to give his address.On one such occasion recently we were given some helpful advice by an eminent lawyer . . .
THE SELLA TURCICA IN POSTPARTUM PITUITARY NECROSIS
Authors: K. RAJASURIYA
Journal: Annals of Internal Medicine (1966)

Letters and Comments1 October 1966THE SELLA TURCICA IN POSTPARTUM PITUITARY NECROSISK. RAJASURIYA, M.D., F.R.C.P.K. RAJASURIYA, M.D., F.R.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-4-866 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: In the article entitled "The Sella Turcica in Postpartum Pituitary Necrosis (Sheehan's Syndrome)" by Drs. Meador and Worrell which appeared in the August 1966 ANNALS (p. 259), it is stated that "No previous reports of sella turcica measurements or mention of small sellar size in patients with Sheehan's syndrome were found in the literature."It is possible that the authors had not seen the article "Post-partum Hypopituitarism in Ceylon" in theJournal of Tropical Medicine and Hygiene, vol. 59 (no. 3) of March 1966, in which we describe one patient who had a "comparatively small pituitary fossa"... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Ceylon Colombo, Ceylon PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1966Volume 65, Issue 4Page: 866-866KeywordsHygieneNecrosis Issue Published: 1 October 1966 PDF DownloadLoading ...
Hawaiian Health Plan: Less Than Meets the Eye?-Reply
Authors: John C. Lewin
Journal: JAMA (1993)

<h3>In Reply.</h3> —Hawaii is the only state to have provided nearly universal access to health care coverage to its residents for almost two decades. We readily acknowledge in our article that there is much about Hawaii's health care system that would benefit from more detailed review. However, we believe that the slowly accumulating body of evidence suggests that in Hawaii as in other places, such as Germany, Japan, and Canada, guaranteeing universal access to health care coverage produces better health outcomes and works to lower costs. We could wait for detailed studies to validate these conclusions (and in fact hope our work stimulates more study of the Hawaii system) but feel that an overview of Hawaii's experience is important for the nation at this critical juncture of health reform. Dr Arensdorf rightly points out the poor status of our mental health/substance abuse system. What he omits is the administration's success