Cimetidine-Induced Anaphylaxis
Authors: ALBERT B. KNAPP
Journal: Annals of Internal Medicine (1982)

Brief Reports1 September 1982Cimetidine-Induced AnaphylaxisALBERT B. KNAPP, M.D., ROBERT S. GRIMSHAW Jr., M.D., JOEL P. GOLDFARB, M.D., PAUL S. FARKAS, M.D., MARK RUBIN, M.D., DAVID L. ROSENSTREICH, M.D.ALBERT B. KNAPP, M.D.Search for more papers by this author, ROBERT S. GRIMSHAW Jr., M.D.Search for more papers by this author, JOEL P. GOLDFARB, M.D.Search for more papers by this author, PAUL S. FARKAS, M.D.Search for more papers by this author, MARK RUBIN, M.D.Search for more papers by this author, DAVID L. ROSENSTREICH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-3-374 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCimetidine, a potent and specific H2 receptor antagonist, is remarkably free of serious side effects (1-5). Allergic sequellae are uncommon and usually cutaneous in nature (5, 6). We report cimetidine-induced anaphylaxis, a previously undescribed complication.A 59-year-old man was admitted for treatment of recurrent pyloric channel ulcer disease shown by endoscopy. On admission he had marked epigastric tenderness without rebound or distention. Bowel sounds were normal and the stool examination was negative for blood. The patient received 25 mg of meperidine (Demerol, Winthrop laboratories, New York, New York) intramuscularly for analgesia. Two hours later the patient received 300 mg of...References1. FINKELSTEINISSELBACHER WK. Cimetidine. N Engl J Med. 1978;299:992-6. CrossrefMedlineGoogle Scholar2. AVELLAMADSENBINDERASKENASE JJHP. Effect of histamine H2-receptor antagonists on delayed hypersensitivity. Lancet. 1978;1:624-6. CrossrefMedlineGoogle Scholar3. FEELYWILKINSONWOOD JGA. Reduction of liver blood flow and propranolol metabolism by cimetidine. N Engl J Med. 1981;304:692-5. CrossrefMedlineGoogle Scholar4. MCMILLENAMBISSIEGEL MDJ. Cimetidine and mental confusion. [Letter]. N Engl J Med. 1978;298:284-5. CrossrefMedlineGoogle Scholar5. MCGUIGAN J. A consideration of the adverse effects of cimetidine. Gastroenterology. 1981;80:181-92. CrossrefMedlineGoogle Scholar6. BURLAND W. Evidence for the safety of cimetidine in the treatment of peptic ulcer disease. In: CREUTZFELDT W, ed. Cimetidine: Proceedings of an International Symposium on Histamine-2 Receptor Antagonists. Amsterdam, Oxford: Excerpta Medica; 1978:238-55. Google Scholar7. DELAUNOIS L. Hypersensitivity to cimetidine [Letter]. N Engl J Med. 1979;300:1216. CrossrefMedlineGoogle Scholar8. JAFFEMARTIN JW. Opioid analgesics and antagonists. In: GILMAN AG, GOODMAN LS, GILMAN A, eds. The Pharmacological Basis of Therapeutics, 6th ed. New York: MacMillan Publishing Corp. , Inc.; 1980:505. Google Scholar9. WALKENSTEINDUBBRANDOLPHWESTLAKESTOTEINTOCCIA SJWWRA. Bioavailability of cimetidine in man. Gastroenterology. 1978;74:360-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Albert Einstein College of Medicine New York, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAnaphylactic reaction to ranitidine (Zantac®)Anaphylaxis Induced by Intravenous Ranitidine Injection: 2 Case Reports - A Case Report -Hypersensitivity reaction to ranitidine: Description of a case and review of the literatureTagamet 51481-61-9Quel est le traitement de la réaction allergique survenant en cours d’anesthésie et en particulier du choc anaphylactique ?Y a-t-il des facteurs favorisant la réaction allergique, inhérents au terrain, aux médicaments, à la technique d'utilisation ? Indication du bilan prédictifQuel est le traitement de la réaction allergique survenant en cours d’anesthésie et en particulier du choc anaphylactique ?Y a-t-il des facteurs favorisant la réaction allergique, inhérents au terrain, aux médicaments, à la technique dˈutilisation ?Indication du bilan prédictifNephrotoxicity and Hepatotoxicity of Histamine H2 Receptor AntagonistsDrug-associated anaphylaxis: 20 years of reporting in the Netherlands (1974-1994) and review of the literatureReferencesCimetidine-Associated Adverse ReactionAdverse Reactions and Interactions with H2-Receptor AntagonistsAnaphylaxisHypersensitivity to CimetidineCimetidine-Induced EosinophiliaTHE FIRST REPORT OF CIMETIDINE-INDUCED ANAPHYLAXIS IN JAPANESEDrug allergy—Problems and strategiesCyclosporin A nephrotoxicity related to changes in haemoglobin concentration.Respiratory symptoms related to work in a factory manufacturing cimetidine tablets.Gastrointestinal drugsCimetidine-induced cutaneous vasculitisAcknowledgments in Cimetidine ReportBERTRAND M. BELL, M.D. 1 September 1982Volume 97, Issue 3Page: 374-375KeywordsAnalgesiaAnaphylaxisBloodEndoscopyUlcers Issue Published: 1 September 1982 PDF DownloadLoading ...