tbuckley/cabot-search huggingface dataset:
COLLIERS 'STRIPES—THE COAL-MINERS' DERMATOSIS.
Authors: F. RAY Bettley
Journal: British Journal of Dermatology (1940)

British Journal of DermatologyVolume 52, Issue 4 p. 129-130 COLLIERS ‘STRIPES—THE COAL-MINERS’ DERMATOSIS. F. RAY Bettley M.D., F. RAY Bettley M.D. Cardiff Royal Infirmary, Wales.Search for more papers by this author F. RAY Bettley M.D., F. RAY Bettley M.D. Cardiff Royal Infirmary, Wales.Search for more papers by this author First published: April 1940 https://doi.org/10.1111/j.1365-2133.1940.tb10849.xCitations: 7Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume52, Issue4April 1940Pages 129-130 RelatedInformation
Analysis of Risk Factors for the Development of Bronchiolitis Obliterans Syndrome
Authors: ALIYA N. HUSAIN, MOMIN T. SIDDIQUI, EARLE W. HOLMES, ARCOT J. CHANDRASEKHAR, MARY McCABE, RUTA RADVANY, EDWARD R. GARRITY
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Chronic rejection after lung transplantation, manifesting as bronchiolitis obliterans syndrome (BOS), has become the dominant challenge to long-term patient and graft survival. In order to elucidate risk factors for development of BOS we utilized the 1995 revision of the working formulation for the classification of lung allograft rejection (), and devised a quantitative method to retrospectively study lung transplant biopsies from all patients who survived at least 90 d. All transbronchial biopsies were regraded 0 to 4 for acute perivascular rejection and lymphocytic bronchitis/bronchiolitis (LBB), and the grades were totaled over a period of time to give two scores, respectively, for each patient. Also examined were timing of acute rejection and LBB episodes and decreased immunosuppression defined as two or more cyclosporine A levels < 200 ng/ml. Sixty-six patients with BOS and 68 with no BOS (NBOS) satisfied our criteria for inclusion in the study. Demographics including age, sex, and primary diagnoses were similar. The mean perivascular score for BOS was 6.2 over a mean follow-up of 822 d (range, 113 to 2,146) compared with 3.2 for NBOS over 550 d (range, 97 to 1,734) mean follow-up. Airway scores were 5.3 and 1.7, respectively, for the same follow-up periods. There was no correlation between length of follow-up and rejection or LBB scores, although mean length of follow-up for the two groups was significantly different. Late acute rejection and LBB were significantly associated with BOS as was decreased immunosuppression. In addition to perivascular rejection, LBB, late acute rejection, and decreased immunosuppression are significant risk factors for the development of BOS. Analysis of the current data leads us to believe that LBB, in the absence of infection, is in fact a manifestation of acute rejection, with similar implications for graft function as acute perivascular rejection.
Effect of house dust mite avoidance measures in children with atopic dermatitis: reply from authors
Authors: G. Ricci, A. Patrizi, F. Specchia, M. Massi
Journal: British Journal of Dermatology (2001)

Journal Article Effect of house dust mite avoidance measures in children with atopic dermatitis: reply from authors Get access G. Ricci, G. Ricci Departments of Pediatrics and *Clinical and Experimental Medicine. Division of Dermatology, University of Bologna, Via Massarenti 11‐40138, Bologna, Italy.E‐mail: ricci@med.unibo.it Search for other works by this author on: Oxford Academic Google Scholar A. Patrizi, A. Patrizi Departments of Pediatrics and *Clinical and Experimental Medicine. Division of Dermatology, University of Bologna, Via Massarenti 11‐40138, Bologna, Italy.E‐mail: ricci@med.unibo.it Search for other works by this author on: Oxford Academic Google Scholar F. Specchia, F. Specchia Departments of Pediatrics and *Clinical and Experimental Medicine. Division of Dermatology, University of Bologna, Via Massarenti 11‐40138, Bologna, Italy.E‐mail: ricci@med.unibo.it Search for other works by this author on: Oxford Academic Google Scholar M. Massi M. Massi Departments of Pediatrics and *Clinical and Experimental Medicine. Division of Dermatology, University of Bologna, Via Massarenti 11‐40138, Bologna, Italy.E‐mail: ricci@med.unibo.it Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 144, Issue 4, 1 April 2001, Page 913, https://doi.org/10.1046/j.1365-2133.2001.04164.x Published: 01 April 2001
Are Medical Schools Neglecting Clinical Skills?
Authors: George L. Engel
Journal: JAMA (1976)

Wiener and Nathanson report in this issue ofThe Journalon the large number of errors in interviewing and physical examination committed by medical house officers at a first-rank hospital.<sup>1</sup>It would be easy to dismiss such charges as unreliable and inconsequential; unreliable because they do not conform with some readers' personal impressions, inconsequential because some may consider clinical observation to have been rendered obsolete by the availability of modern diagnostic technology. Actually, this communication should provoke sober soul-searching among the medical profession. Is our much vaunted American medical educational system failing in its responsibility to prepare physicians in the most fundamental of all medical skills: clinical observation and clinical reasoning?<sup>2</sup> Unfortunately, the answer appears to be in the affirmative. Physicians reading this who have graduated in the last two decades need only recollect their own personal instruction as students in this area. In informal inquiries of medical
Terlipressin in bleeding esophageal varices: A placebo-controlled, double-blind study
Authors: Siegfried Walker M.D., Adolf Stiehl, Richard Raedsch, Burkhard Kommerell
Journal: Hepatology (1986)

The effect of terlipressin (N-α-triglycyl-8-lysinevasopressin) in bleeding esophageal varices was evaluated in a prospective placebo-controlled study. Fifty bleeding episodes from esophagealvarices in 34 patients were randomized. Standard therapy with transfusions, fluid and electrolyte correction, and lactulose was performed in both groups. Balloon tamponade was used in 20 bleeding episodes in the terlipressin group and in 19 bleeding episodes in the control group. In the terlipressin group, hemorrhage was controlled in all bleeding episodes (25/25) whereas in the placebo group, only 20 of 25 bleeding episodes could be stopped within 36 hr (p < 0.05). Sclerotherapy was performed in five bleeding episodes in the terlipressin group and in seven bleeding episodes in the placebo group. Treatment failures, including patients who required sclerotherapy, occurred in five bleedings in the terlipressin group and in 12 in the control group (p < 0.05). The hospital mortality rate was 12% (3/25) in the terlipressin group and 32% (8/25) in the control group. Patients in the terlipressin group required fewer transfusions, the balloon needed to be inflated for a shorter time and theduration of bleeding was shorter than in the control group. However, these differences were not significant. These data do not allow conclusions concerning monotherapy with terlipressin, but they indicate that the addition of terlipressin to standard therapy may increase the control rate in acute variceal hemorrhage.
Intensive treatment for type 1 diabetes is associated with lower risk of death
Authors: Jacqui Wise
Journal: BMJ (2015)

Initial intensive treatment for type 1 diabetes is associated with a modestly lower all cause mortality rate than conventional therapy, research published in JAMA has shown.

Researchers carried out a long term follow-up study of participants in the original Diabetes Control and Complications Trial, which included 1441 patients with type 1 diabetes who were aged 13 to 39.1 Of these people, 711 were assigned to receive intensive therapy that aimed to get …
Mutations in dominant human myotonia congenita drastically alter the voltage dependence of the CIC-1 chloride channel
Authors: Michael Pusch, Klaus Steinmeyer, Manuela C. Koch, Thomas J. Jentsch
Journal: Neuron (1995)

Autosomal dominant myotonia congenita (Thomsen's disease) is caused by mutations in the muscle chloride channel CIC-1. Several point mutations found in affected families (I29OM, R317Q, P480L, and Q552R) dramatically shift gating to positive voltages in mutant/WT heterooligomeric channels, and when measurable, even more so in mutant homooligomers. These channels can no longer contribute to the repolarization of action potentials, fully explaining why they cause dominant myotonia. Most replacements of the isoleucine at position 290 shift gating toward positive voltages. Mutant/WT heterooligomers can be partially activated by repetitive depolarizations, suggesting a role in shortening myotonic runs. Remarkably, a human mutation affecting an adjacent residue (E291K) is fully recessive. Large shifts in the voltage dependence of gating may be common to many mutations in dominant myotonia congenita.
Insertion of Retroviral Vectors in NOD/SCID Repopulating Human Peripheral Blood Progenitor Cells Occurs Preferentially in the Vicinity of Transcription Start Regions and in Introns
Authors: Stephanie Laufs, K. Zsuzsanna Nagy, Frank A. Giordano, Agnes Hotz-Wagenblatt, W. Jens Zeller, Stefan Fruehauf
Journal: Molecular Therapy (2004)

Reports on insertional "genotoxicity" in patients have created intense interest in characterizing retroviral vector integrations on the genomic level. The retroviral vector SF91m3 was used for transduction of human peripheral blood progenitor cells (PBPC). These PBPC were transplanted into nonobese diabetic/severe combined immunodeficient mice. A total of 186 retroviral vector integration sites were isolated by ligation-mediated PCR from chimeric mouse bone marrow of five PBPC donors, sequenced, and blasted against the human genome. Preferred integration near the transcription start regions, within CpG islands, and within Alu regions was observed. Detailed analysis of targeted RefSeq genes showed a favored integration within the first intron. Integrations were most common in genes coding for signaling proteins, transcription factors, and kinases. In all genes targeted independently multiple times the respective orientation of the provirus within the gene was identical, indicating integration hot spot regions and similar steric determinants for integration sites. Possible explanations for these findings could be nonrandom vector integration, clonal selection due to gene expression interference, or engraftment issues related to gene insertion in signaling and cell cycle genes. The low frequency of integrations in exons may be reassuring as to the safety of retroviral gene therapy with normal human PBPC.
Emerging infectious diseases and pandemic potential: status quo and reducing risk of global spread
Authors: Brian McCloskey, Osman Dar, Alimuddin Zumla, David L Heymann
Journal: The Lancet Infectious Diseases (2014)

Emerging infectious diseases are an important public health threat and infections with pandemic potential are a major global risk. Although much has been learned from previous events the evidence for mitigating actions is not definitive and pandemic preparedness remains a political and scientific challenge. A need exists to develop trust and effective meaningful collaboration between countries to help with rapid detection of potential pandemic infections and initiate public health actions. This collaboration should be within the framework of the International Health Regulations. Collaboration between countries should be encouraged in a way that acknowledges the benefits that derive from sharing biological material and establishing equitable collaborative research partnerships. The focus of pandemic preparedness should include upstream prevention through better collaboration between human and animal health sciences to enhance capacity to identify potential pathogens before they become serious human threats, and to prevent their emergence where possible. The one-health approach provides a means to develop this and could potentially enhance alignment of global health and trade priorities.
Anti-CCR4 Monoclonal Antibody Mogamulizumab for the Treatment of EBV-Associated T- and NK-Cell Lymphoproliferative Diseases
Authors: Tetsuhiro Kanazawa, Yutaka Hiramatsu, Seiko Iwata, Mohammed Siddiquey, Yoshitaka Sato, Michio Suzuki, Yoshinori Ito, Fumi Goshima, Takayuki Murata, Hiroshi Kimura
Journal: Clinical Cancer Research (2014)

Epstein-Barr virus (EBV) infects not only B cells but also T cells and natural killer (NK) cells, and T- and NK-cell lymphoproliferative diseases (T/NK-LPD) that are refractory to conventional chemotherapies may develop. To identify a molecular-targeted therapy for EBV-associated T/NK-LPDs, we investigated whether CC chemokine receptor 4 (CCR4) was expressed on EBV-infected T and/or NK cells and whether a humanized anti-CCR4 monoclonal antibody, mogamulizumab, was effective.CCR4 expression was examined in various cell lines. In vitro, the effects of mogamulizumab on cell lines were evaluated in the presence of peripheral blood mononuclear cells from volunteers. In vivo, the effects of mogamulizumab were evaluated using a murine xenograft model. CCR4 expression was examined on EBV-infected cells from patients with EBV-associated T/NK-LPDs. Ex vivo, the effects of mogamulizumab were evaluated using patient lymphocytes.CCR4 expression was confirmed in most EBV-positive T and NK cell lines. Mogamulizumab induced antibody-dependent cellular cytotoxicity (ADCC) activity against CCR4-positive cell lines, and inhibited the growth of EBV-positive NK-cell lymphomas in a murine xenograft model. Furthermore, CCR4 was expressed on EBV-infected cells in 8 of 17 patients with EBV-associated T/NK-LPDs. Interestingly, CCR4 was positive in 5 of 5 patients with hydroa vacciniforme, a photodermatosis caused by the clonal expansion of EBV-infected γδT cells. EBV-positive γδT cells were obtained from a patient with hydroa vacciniforme and subjected to an antibody-dependent cell-mediated cytotoxicity (ADCC) assay. The γδT cells that were positive for CCR4 were killed by mogamulizumab via ADCC.These results indicate that mogamulizumab may be a therapeutic option against EBV-associated T/NK-LPDs.
Elevated n-alkanes in congenital ichthyosiform erythroderma. Phenotypic differentiation of two types of autosomal recessive ichthyosis.
Authors: M L Williams, P M Elias
Journal: Journal of Clinical Investigation (1984)

Previously considered to represent a single genetic disorder, autosomal recessive ichthyosis was examined in clinical and lipid biochemical studies of 18 patients with this condition and instead disclosed to be two distinct diseases. Six patients displayed clinical features of classical lamellar ichthyosis (LI), which is characterized by monomorphous features, including large, dark, platelike scales, severe ectropion, and a uniformly severe, unremitting course. 11 patients displayed clinical features of nonbullous congenital ichthyosiform erythroderma (CIE) characterized by fine white scales, prominent erythroderma, a milder course, and a variable prognosis. CIE could be separated biochemically from LI by the invariable presence of elevated quantities of n-alkanes in scale (CIE, 24.8 +/- 1.9% vs. LI, 7.2 +/- 1.6%, and normal, 6.5 +/- 0.9%), which suggested a primary disorder in neutral lipid metabolism. In light of the distinctive clinical features of each, these biochemical studies indicate that autosomal recessive ichthyosis comprises two distinct disorders.
Factors affecting the release of lactate dehydrogenase from isolated rat heart after calcium and magnesium free perfusions
Authors: J. D. LEIRIS, D. FEUVRAY
Journal: Cardiovascular Research (1973)

Journal Article Factors affecting the release of lactate dehydrogenase from isolated rat heart after calcium and magnesium free perfusions Get access J. DE LEIRIS, J. DE LEIRIS From the Laboratoire de Physiologie Comparée-Université Paris XI, Centre d'Orsay, 91 Orsay, France Search for other works by this author on: Oxford Academic PubMed Google Scholar D. FEUVRAY D. FEUVRAY From the Laboratoire de Physiologie Comparée-Université Paris XI, Centre d'Orsay, 91 Orsay, France Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 7, Issue 3, May 1973, Pages 383–390, https://doi.org/10.1093/cvr/7.3.383 Published: 01 May 1973
TCT-384 Effect of Ezetimibe in addition to Statin Therapy in statin naïve STEMI patients assessed by Optical Coherence Tomography and Intravascular Ultrasound with iMap (The OCTIVUS trial)
Authors: Mikkel Hougaard, Henrik S. Hansen, Anders Junker, Per Thayssen, Lisbeth Antonsen, Akiko Maehara, Lisette Okkels Jensen
Journal: Journal of the American College of Cardiology (2014)
Homocysteine-mediated thrombosis and angiostasis in vascular pathobiology
Authors: Joseph Loscalzo
Journal: Journal of Clinical Investigation (2009)

The mechanisms by which homocysteine contributes to atherothrombosis are complex and their in vivo relevance uncertain. In this issue of the JCI, Jacovina and colleagues report a unique in vivo mechanism by which homocysteine may contribute to vascular disease (see the related article beginning on page 3384). This group had previously reported that homocysteine impairs endothelial cell surface plasminogen activation by posttranslationally modifying annexin A2, the coreceptor for plasminogen and tissue plasminogen activator. They now show that an annexin A2–deficient mouse rendered hyperhomocysteinemic by dietary means has impaired fibrinolysis, perivascular fibrin persistence, and attenuated angiogenesis (angiostasis). Potential mechanisms by which homocysteine-dependent changes in endothelial phenotype link thrombosis to angiostasis are reviewed and their relationship to homocysteine-dependent vascular disease considered.
Lead isotopes as a supplementary tool in the routine evaluation of household lead hazards.
Authors: R H Gwiazda, D R Smith
Journal: Environmental Health Perspectives (2000)

The advent of magnetic sector inductively coupled plasma-mass spectrometry (ICP-MS) allows rapid, accurate, and precise measurement of lead isotopes in environmental and biological samples at a lower cost than traditional methods. This may increase the feasibility of including lead isotope measurements as a routine tool to identify household sources of lead exposure to children. Here, we present three household case studies to illustrate how lead hazard evaluations by an environmental specialist could be supplemented with routine lead isotope analyses of potential lead sources and blood. Sampling for lead isotopes was undertaken following the U.S. Department of Housing and Urban Development regulatory guidelines for the evaluation of lead hazards in housing, and with the consideration of minimizing the additional costs associated with lead isotope measurements. The range of isotopic ratios within a single residence was large enough to allow the characterization of different lead sources, particularly when both major (e.g., (207)Pb/(206)Pb) and minor (e.g., (206)Pb/(204)Pb) isotope ratios were considered. These cases illustrate the utility of the lead isotope method to identify main source(s) of lead exposure to the child; discard unlikely sources of exposure to the child; point to sources of lead to dust; and substantiate or refine the environmental assessment based exclusively on lead concentrations and loadings. Thus, a more effective evaluation of household lead hazards would likely benefit from considering a) lead concentrations and loadings in and around the household environment; b) all isotopic ratios of potential lead sources within that environment; and c) information about behavioral habits, as well as an evaluation of viable pathways of exposure to the child.
Veratrum Viride and Essential Hypertension
Authors: Robert W. Wilkins
Journal: New England Journal of Medicine (1950)

VERATRUM viride, the American false hellebore, has been used intermittently for over a hundred years in the treatment of fever, tachycardia and disturbances of the circulation. However, in modern times it has been generally discredited for clinical use, except by a rare pharmacologist1 and an occasional obstetrician who has continued to advocate it for the relief of acute toxemias of pregnancy.2 3 4 Recently, it has been tried clinically in cases of essential hypertension,5 6 7 with results favorable enough to stimulate physiologic studies of its hemodynamic effects in man8 , 9 and renewed pharmacologic attempts at isolation of its clinically active principles.10 , 11 This paper . . .
Levodopa and Melanoma-Reply
Authors: Michael M. Wick
Journal: JAMA (1979)

The letter by Drs Fermaglich and Delaney provides us with the opportunity to restate the major points in our article. We stated that levodopa use was not responsible for the rapid rise in occurrence of melanoma noted during the past decade. We noted the infrequency (one in 1,099) with which levodopa exposure was found in a prospectively collected group of patients with primary cutaneous melanoma. We did not state that levodopa should be given carte blanche to the rare patient with Parkinson's disease and malignant melanoma. What we did say was that levodopa should not be withheld from the patient with Parkinson's disease, for whom it may be useful, because of fear based on present evidence that malignant melanomas might be induced. Had we been aware of the article of Fermaglich and Delaney,<sup>1</sup>which was published in a European journal (<i>Zeitschrift für Neurologie</i>) and not indexed in
Right and Left Myocardial Antioxidant Responses During Heart Failure Subsequent to Myocardial Infarction
Authors: Michael F. Hill, Pawan K. Singal
Journal: Circulation (1997)

Background Heart failure subsequent to myocardial infarction (MI) is accompanied by depressed antioxidants and increased oxidative stress in the myocardium. Antioxidant enzyme activities and oxidative stress were examined in the viable left (LV) and right (RV) ventricles in relation to their hemodynamic function. Methods and Results The left coronary artery in rats was ligated. At 1 week after MI, LV systolic pressure (LVSP), LV end-diastolic pressure (LVEDP), and RV end-diastolic pressure (RVEDP) remained near control values, whereas RV systolic pressure (RVSP) was significantly elevated. In the 4, 8, and 16 week post-MI animals, LVSP was significantly reduced, with values of 112.0±1.57, 99.9±0.52, and 89.2±1.4 mm Hg, whereas LVEDP was significantly elevated, with values of 8.2±0.52, 17.4±1.7, and 31.4±1.5 mm Hg, respectively. RVEDP was higher at 8 and 16 weeks, and RVSP was significantly reduced at 16 weeks. At 1 week after MI, myocardial catalase activity in the LV was maintained near control levels, whereas in the RV, it was 134% compared with its control value. At 4, 8, and 16 weeks, catalase activity in the LV was 71%, 48%, and 28% of respective controls. Catalase activity in the RV was significantly reduced only at 16 weeks. A similar trend was seen with respect to glutathione peroxidase activity. Reduced/oxidized glutathione ratio was significantly depressed in the LV at 1, 4, 8, and 16 weeks, whereas in the RV, this ratio was significantly reduced only at 8 and 16 weeks. Myocardial lipid peroxidation in the LV at 4, 8, and 16 weeks was elevated by ≈40%, 51%, and 100%, respectively, whereas in the RV, an increase of ≈50% was seen only at 16 weeks. Conclusions These data show that heart failure subsequent to MI is associated with an antioxidant deficit as well as increased oxidative stress, first in the LV, followed by the RV. Furthermore, these changes correlated with the hemodynamic function in each of the ventricles, suggesting their role in the pathogenesis of ventricular dysfunction.