tbuckley/cabot-search huggingface dataset:
Antenatal ultrasonography to detect fetal renal abnormalities: a prospective screening programme.
Authors: L. N. Livera, D. S. Brookfield, J. A. Egginton, J. M. Hawnaur
Journal: BMJ (1989)

OBJECTIVE--To evaluate screening for abnormalities of the fetal renal tract by ultrasonography and to determine the incidence of such abnormalities in a population. DESIGN--A 12 month prospective population study. Follow up of infants to between 9 and 18 months. SETTING--A district general hospital. PARTICIPANTS--6292 Pregnant women reaching 28 weeks9 gestation within the study period. INTERVENTIONS--Antenatal ultrasound scanning was offered to all of the women. Babies in whom an abnormality of the renal tract had been detected antenatally underwent ultrasound scanning at the end of the first week. If the abnormality was confirmed contrast radiography was performed. END POINT--Confirmation of suspected renal abnormality by postnatal investigations. Detection of abnormality in children thought to be normal antenatally. MEASUREMENTS AND MAIN RESULTS--Of the 92 babies who had abnormal antenatal scans, 42 had abnormalities confirmed postnatally. Four of them died and 21 had had or were awaiting an operation at 18 months9 follow up. Seven children had renal abnormalities that were missed antenatally. The incidence of abnormalities detected by screening antenatally was 0.65%, and the overall incidence at 18 months9 follow up was 0.76%. CONCLUSIONS--The incidence of structural renal abnormalities in babies is higher than reported previously. Antenatal ultrasonography is an effective way of detecting such abnormalities.
Effect of intestinal resection on serum antibodies to the mycobacterial 45/48 kilodalton doublet antigen in Crohn's disease.
Authors: G Kreuzpaintner, P K Das, A Stronkhorst, A W Slob, G Strohmeyer
Journal: Gut (1995)

<h3>Abstract</h3> Ebola virus (EBOV) inclusion bodies (IBs) are cytoplasmic sites of nucleocapsid formation and RNA replication, housing key steps in the virus life cycle that warrant further investigation. During infection IBs display dynamic properties regarding their size and location. Also, the contents of IBs must transition prior to further viral maturation, assembly and release, implying additional steps in IB function. Interestingly, expression of the viral nucleoprotein (NP) alone is sufficient for generation of IBs, indicating that it plays an important role in IB formation during infection. In addition to NP, other components of the nucleocapsid localize to IBs, including VP35, VP24, VP30 and the RNA polymerase L. Previously we defined and solved the crystal structure of the C-terminal domain of NP (NP-Ct), but its role in virus replication remained unclear. Here we show that NP-Ct is absolutely required for IB formation when NP is expressed alone. Interestingly, we find that NP-Ct is also required for production of infectious virus-like particles and retention of viral RNA within these particles. Furthermore, co-expression of the nucleocapsid component VP35 overcomes deletion of NP-Ct in triggering IB formation, demonstrating a functional interaction between the two proteins. Of all the EBOV proteins only VP35 is able to overcome the defect in IB formation caused by deletion of NP-Ct. This effect is mediated by a novel protein-protein interaction between VP35 and NP that controls both regulation of IB formation and RNA replication itself, and which is mediated by a newly identified domain of NP, the “central domain” (CD). <h3>Importance</h3> Inclusion bodies (IBs) are cytoplasmic sites of RNA synthesis for a variety of negative sense RNA viruses including Ebola virus. In addition to housing important steps in the viral life cycle, IBs protect new viral RNA from innate immune attack and contain specific host proteins whose function is under study. A key viral factor in Ebola virus IB formation is the nucleoprotein, NP, which also is important in RNA encapsidation and synthesis. In this study, we have identified two domains of NP that control inclusion body formation. One of these, the central domain (CD), interacts with viral protein VP35 to control both inclusion body formation and RNA synthesis. The other is the NP C-terminal domain (NP-Ct), whose function has not previously been reported. These findings contribute to a model in which NP and its interactions with VP35 link the establishment of IBs to the synthesis of viral RNA.
Stimulant Medications in Tourette's Syndrome
Authors: Marcos Chapunoff
Journal: JAMA (1982)

To the Editor.—  In the article Stimulant Medications Precipitate Tourette's Syndrome, by Lowe et al (1982; 247:1729), an apparent causal relationship between administration of stimulant medications and the development of Tourette's syndrome is described. In the practice of child psychiatry, I have encountered children for whom stimulants had been prescribed on a trial basis approach, and without the benefit of a thorough clinical assessment. Experience also indicates that these drugs are prescribed in dosages that are excessive for the patients' needs.  It would have been helpful if more detailed data would have been provided about the 15 patients in the authors' sample, such as (1) dosages and duration of administration for each drug, and (2) whether any drug vacations from stimulants were instituted, and for how long.
Evaluation of a New Fibre Colonoscope the Olympus TCF-2L
Authors: G. Nagy, D. Fevre, P. R. Green
Journal: Endoscopy (1976)

Experience with the new Olympus twin channel TCF-2L colonoscope is presented. Based on 60 examinations including 25 polypectomies it is concluded that the instrument when compared with other colonoscopes is easier to handle and its advancement within the colon is faster, smoother and therefore less disagreeable to the patient. The proximal colon is easier to reach than previously experienced. Polypectomy and retrieving of polyps can efficiently be undertaken. This instrument will undoubtedly further enhance the usefulness and therapeutic value of fibre colonoscopy.
700 RISK OF HEPATITIS B AND EFFICACY OF TREATMENT WITH LAMIVUDINE IN PATIENTS UNDERGOING ALLO-SCT
Authors: A. Marzano, L. Mezzabotta, L. Giaccone, I. Resta, A. Marengo, F. Fiore, R. Sorasio, M. Festuccia, M. Boccadoro, B. Bruno, M. Rizzetto
Journal: Journal of Hepatology (2008)
INTERACTIONS BETWEEN SMOKING, CIRCULATING PULMONARY SURFACTANT PROTEIN-B AND AORTIC ATHEROSCLEROSIS IN THE DALLAS HEART STUDY
Authors: Ann B. Nguyen, Anand Rohatgi, Christine K. Garcia, Colby R. Ayers, Sandeep Das, Susan Lakoski, Jarett Berry, Amit Khera, Darren K. McGuire, James de Lemos
Journal: Journal of the American College of Cardiology (2011)
Abstract B25: Effects of co-injection of somatic cells on stem cell allograft success and differentiation
Authors: Jong-Heum Park, Seo-Jin Oh, Seung-Pyo Gong, Bo-Yun Kim, Ji-Yeon Ahn, Jeong-Mook Lim
Journal: Clinical Cancer Research (2010)

Abstract Two consecutive experiments were conducted for understanding immunity, stemness, and tumorigenesis of the embryonic stem cells (ESCs) in their allograft. In the first series of experiment, we evaluated whether co-injection of the stem cells with somatic cells could evade the immune response. Donor B6CBAF1 mouse ESCs were subcutaneously co-injected either alone or with ovarian stromal cells, fetal fibroblasts, or adult fibroblasts isolated from the recipient B6D2F1 mouse strain. ESCs by themselves induced teratomas (14%). However, when somatic cells were injected together, ESC-mediated teratoma formation significantly increased (33-75%). Especially, the highest rate of the teratoma formation was observed in ESCs and fetal fibroblasts co-injected recipient B6D2F1 mice (75%). Next, we derived ESC-like, cancer stem cells from the teratomas with enzymatic digestion and their differentiation potential was subsequently evaluated. Except for one cell line, other all cell lines showed a similar morphology to that of original ESCs and retained alkaline phosphatase activity, ESC-specific gene expression (Oct-4, Nanog, Cripto, and Rex-1), and Oct-4 protein expression regardless of their increased abnormality in chromosome number. Relative quantification of lineage-specific gene (Nestin, SMA, Desmin, and Krt8) expression of teratoma-derived cell lines showed the significant changes between the ESCs and the teratoma-derived, ESC-like cells derived from the cell co-injection. Variations in the type of co-injected cells led to lineage-specific changes, changes in gene expression in isolated colony-forming cells, and alterations in stem-cell-like cells derived from allografted tissues. In conclusion, our results suggest that cell-to-cell interaction regulates cellular immunity for implanted cells, which further affects tumorigenesis and stemness [Supported by a grant (SC-5160) from Stem Cell Research Center of the 21st Century Frontier Research Program awarded by Jeong-Mook Lim]. Jong-Heum Park and Seo-Jin Oh contributed equally to this work. Citation Information: Clin Cancer Res 2010;16(14 Suppl):B25.
Potentially harmful effects of inspiratory synchronization during pressure preset ventilation
Authors: J. C. M. Richard, A. Lyazidi, E. Akoumianaki, S. Mortaza, R. L. Cordioli, J. C. Lefebvre, N. Rey, L. Piquilloud, G. F. Sferrazza-Papa, A. Mercat, L. Brochard
Journal: Intensive Care Medicine (2013)
Conserved cytoplasmic tyrosine residues of the gamma subunit are required for a phagocytic signal mediated by Fc gamma RIIIA.
Authors: J G Park, R K Murray, P Chien, C Darby, A D Schreiber
Journal: Journal of Clinical Investigation (1993)

Fc receptors for immunoglobulins are found on many cells and are important in host defense. We transfected Fc gamma RIIIA, present on macrophages and natural killer (NK) cells, into COS-1 cells to study its role in phagocytosis and calcium mobilization in the absence of other Fc gamma receptors. Human Fc gamma RIIIA-alpha (CD16) was cotransfected with its associated chains, either Fc gamma RIIIA gamma or zeta. Both gamma and zeta were observed to induce a phagocytic signal, but gamma was at least sixfold more effective than zeta. Conservative substitution by phenylalanine of either one of the two cytoplasmic tyrosine residues in the gamma chain resulted in markedly diminished phagocytosis and calcium mobilization. Tyrphostin 23, an inhibitor of tyrosine kinases, reversibly inhibited phagocytosis. Further, in vitro kinase assays with the wild type and mutant gamma chains demonstrated that the wild type gamma chain, but not the mutant gamma chains, is phosphorylated. These results suggest that the cytoplasmic tyrosine residues and tyrosine phosphorylation are required for Fc gamma RIIIA to mediate two signal transduction events: phagocytosis and calcium mobilization.
Application of Ultrasound Contrast Agents for the Characterization of Female Urethral Vascularization in Healthy Pre- and Postmenopausal Volunteers: Preliminary Report
Authors: Salvatore Siracusano, Michele Bertolotto, Antonio Cucchi, Nikolitsa Lampropoulou, Anna Tiberio, Cristiana Gasparini, Stefano Ciciliato, Emanuele Belgrano
Journal: European Urology (2006)
Continuous infusion of porcine factor VIII in the management of patients with factor VIII inhibitors
Authors: Morel Rubinger, Donald S. Houston, Nora Schwetz, Donna M. M. Woloschuk, Sara J. Israels, James B. Johnston
Journal: American Journal of Hematology (1997)

The effectiveness of continuous infusion porcine factor VIII (PFVIII) has been evaluated in the treatment of 7 consecutive patients with factor VIII(FVIII) inhibitors. Two patients had hemophilia A and five were nonhemophiliacs with acquired FVIII inhibitors. The median pretreatment anti-porcine FVIII titre was 0.2 (range: 0–15.0) Bethesda units (BU), and the anti-human FVIII titer was 12.0 BU (range: 2.4–50.0). All patients presented with major bleeding. Patients were given a bolus dose of PFVIII followed by continuous infusion. Six patients also received immunosuppressive therapy. Therapeutic FVIII levels (>0.5 U/ml) were achieved in 6 of 7 patients at a median time of 12.5 hr, and then maintained with continuous infusion PFVIII. Six patients were treated for more than 7 days, and in four of these there was a decline in FVIII recovery between days 7 to 11, presumably related to a rising antibody response to PFVIII. These four patients were plasmapheresed and the three patients with autoantibodies recovered therapeutic FVIII levels but this did not occur in the patient with hemophilia. Thrombocytopenia developed in 4 patients at days 18 to 24, with the platelet count falling to 11 to 87 × 109/L, and the PFVIII was discontinued in 3 patients. All patients recovered from the acute bleeding events. With prolonged immunosuppressive therapy, the FVIII inhibitor disappeared in all patients with autoantibodies and there have been no relapses after a median follow-up period of 581 days. This study demonstrates that continuous infusion PFVIII is an effective therapy for patients with FVIII inhibitors, but that prolonged treatment is associated with the development of inhibitors to porcine FVIII and severe thrombocytopenia, which readily corrects with discontinuation of PFVIII. Am. J. Hematol. 56:112–118, 1997. © 1997 Wiley-Liss, Inc.
Comparison of Large and Small Doses of Hormones in the Treatment of Acute Rheumatic Carditis
Authors: SUJOY B. ROY, BENEDICT F. MASSELL
Journal: Circulation (1956)

Disappearance of significant murmurs was twice as common in 47 rheumatic children treated with large doses of hormones as in a comparable group of 41 children treated with small doses of hormones. Results were also related to the duration of illness before therapy was started. The findings suggest that the divergencies of opinion regarding the efficacy of hormones in the treatment of acute rheumatic carditis may in part be explained on the basis of differences in doses of hormones, in duration of therapy, and in duration of illness before the beginning of therapy.
Exocrine pancreatic function tests.
Authors: P G Lankisch
Journal: Gut (1982)

Progress reportExocrine pancreatic function tests Pancreatic disease may be classified as inflammatory, neoplastic traumatic, or genetic.1According to the definition of Marseillesi inflammatory diseases may be subdivided into (1) acute pancreatitis, (2) relapsing acute pancreatitis, (3) relapsing chronic pancreatitis, and (4) chronic pancreatitis (Table 1).The first classification is primarily based on aetiological, the second on clinical and functional and/or morphological criteria.For the diagnosis of pancreatic disease, pancreatic function tests are needed among other diagnostic procedures to assess the amount of functional damage.As pancreatic function returns to normal after attacks of acute or relapsing acute pancreatitis, unlike what is found in the chronic form of the disease, pancreatic function tests are necessary to differentiate between acute and chronic presentations of the disease.Since the pioneer work of Chiray et a13 and Lagerlof4 on the evaluation of the secretin test in pancreatic diseases, a variety of exocrine pancreatic function tests have been developed over the last 50 years.They may be divided into the following categories (Table 2): 1 Direct tests, in which pancreatic flow, bicarbonate, and enzyme secretion are measured in duodenal or pure pancreatic juice after exogenous hormonal stimulation of the pancreas.2 Indirect tests, which make use of nutrients for endogenous stimulation of pancreatic enzyme secretion.3 Faecal tests, which include microscopic inspection of stools and estimation of faecal trypsin, chymotrypsin, fat and nitrogen content. 4Serum enzyme or isoenzyme estimation, with or without previous hormonal stimulation.The purpose of this progress report is (1) to discuss current exocrine pancreatic function tests with special reference to their practicability, (2) to state whether these tests are able to differentiate between impairment of pancreatic function of diverse aetiology, and (3) to suggest possible ways of refining tubeless tests.Three excellent reviews have been published Table 1 Classification ofpancreatic diseases I Inflammatory III Traumatic Acute pancreatitis Non-penetrating or blunt traumas Relapsing acute pancreatitis Penetrating injuries Chronic relapsing pancreatitis Chronic ('painless') pancreatitis IV Genetic Cystic fibrosis II Neoplastic Hereditary and familial pancreatitis Ductal origin Parenchymal origin (acinar cells) Islet cell origin 777
Mergers and Acquisitions — Who Benefits? Who Loses?
Authors: Jerome P. Kassirer
Journal: New England Journal of Medicine (1996)

Institutions that have been longtime rivals are merging. In Massachusetts, Brigham and Women's Hospital and the Massachusetts General Hospital have merged, and two of the state's largest health maintenance organizations (HMOs) — Harvard Community Health Plan and Pilgrim Health Care — have merged. In Philadelphia, Hahnemann Medical School and the Medical College of Pennsylvania have merged. Glaxo merged with Burroughs Wellcome, and Upjohn merged with Pharmacia. Many health care organizations are also expanding their range of services by acquiring other organizations. Hospitals across the country are acquiring groups of primary care physicians, outpatient clinics, rehabilitation units, nursing homes, and home . . .
Use of personal measurements for ozone exposure assessment: a pilot study.
Authors: L J Liu, P Koutrakis, H H Suh, J D Mulik, R M Burton
Journal: Environmental Health Perspectives (1993)

During summer 1991, we collected indoor, outdoor, and personal ozone concentration data as well as time-activity data in State College, Pennsylvania. These concentrations were measured for 23 children and their homes using passive ozone samplers. Outdoor concentrations were also measured at a stationary ambient monitoring site. Results from this pilot study demonstrate that fixed-site ambient measurements may not adequately represent individual exposures. Outdoor ozone concentrations showed substantial spatial variation between rural and residential regions. Ignoring this spatial variation by using fixed-site measurements to estimate personal exposures can result in an error as high as 127%. In addition, evidence from our pilot study indicates that ozone concentrations of a single indoor microenvironment may not represent those of other indoor microenvironments. Personal exposures were significantly correlated with both indoor (r = 0.55) and outdoor (r = 0.41) concentrations measured at home sites. Multiple regression analyses identified indoor ozone concentrations as the most important predictors of personal exposures. However, models based on time-weighted indoor and outdoor concentrations explained only 40% of the variability in personal exposures. When the model included observations for only those participants who spent the majority of their day in or near their homes, an R2 of 0.76 resulted when estimates were regressed on measured personal exposures. It is evident that contributions from diverse indoor and outdoor microenvironments must be considered to estimate personal ozone exposures accurately.
Psychological Mechanisms of Flooding (Implosion) Therapy
Authors: Christian Astrup
Journal: Psychotherapy and Psychosomatics (1975)

Research Articles| February 12 2010 Psychological Mechanisms of Flooding (Implosion) Therapy Subject Area: Psychiatry and Psychology Christian Astrup Christian Astrup Tromsö University, Tromsö Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1975) 25 (1-6): 63–68. https://doi.org/10.1159/000286832 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Christian Astrup; Psychological Mechanisms of Flooding (Implosion) Therapy. Psychother Psychosom 31 December 1975; 25 (1-6): 63–68. https://doi.org/10.1159/000286832 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1975Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Identification of antigens of Mycobacterium tuberculosis using human monoclonal antibodies.
Authors: R S Wallis, S L Alde, D V Havlir, M H Amir-Tahmasseb, T M Daniel, J J Ellner
Journal: Journal of Clinical Investigation (1989)

Pleural tuberculosis constitutes a human model of local protective immunity to mycobacterial infection as the disease is usually self-limited and recurrent pleurisy is rare. To identify potentially protective antigens of Mycobacterium tuberculosis, 37 human pleural fluid B cell clones were established using EBV and their supernatants assayed by ELISA and Western blot for antibody reactivity with M. tuberculosis sonicate and culture filtrate. One antibody identified 29,000, 31,000, and 33,000 bands in culture filtrate, and 31,000, 33,000, and 47,000 bands in sonicate; its species reactivity by ELISA was limited to M. tuberculosis. Eight antibodies identified a 31,000 band in culture filtrate and a 68,000 band in M. tuberculosis sonicate, suggesting recognition of a secreted antigen. The species crossreactivity of these eight antibodies extended to M. avium. Six antibodies identified multiple bands and had crossreactivity that included M. avium and M. kansasii. There was no reactivity with recombinant M. tuberculosis 65,000 antigen. Tuberculous pleurisy may prove useful in the identification of potentially protective mycobacterial antigens, particularly those secreted during active infection, and thus accessible to the human immune response.
Woman dies two months after food withdrawal
Authors: Z. Kmietowicz
Journal: BMJ (1997)

The death of an 85 year old woman two months after her doctor ordered withdrawal of her feeding supplements has reopened the debate about assisted deaths. The Voluntary Euthanasia Society asks why doctors are allowed to stop treatment to hasten death but patients are unable to request a lethal injection.

May Ormerod died in August 1995 weighing less than 25 kg after Dr Ken Taylor instructed nurses at Oxford House in Preston to stop feeding her the liquid food …