Postmenopausal Hormone Therapy and Cardiovascular Disease
Authors: Carsten Otto, Klaus Parhofer
Journal: Annals of Internal Medicine (2001)

Letters18 December 2001Postmenopausal Hormone Therapy and Cardiovascular DiseaseCarsten Otto, MD and Klaus Parhofer, MDCarsten Otto, MDUniversity of Munich; D-81377 Munich, GermanySearch for more papers by this author and Klaus Parhofer, MDUniversity of Munich; D-81377 Munich, GermanySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-12-200112180-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In the recent analysis from the Nurses' Health Study, Grodstein and colleagues reported a decreased risk for coronary events in postmenopausal women who were receiving hormone replacement therapy (HRT) and had no previous coronary heart disease (1). This contrasts with results from randomized, secondary prevention trials, which showed no overall beneficial effect of postmenopausal HRT on cardiovascular risk (2, 3). The Heart and Estrogen/progestin Replacement Study (HERS) even revealed a 50% increase in cardiac event rate during the first year of therapy (2, 4). Similarly, the investigators of the Women's Health Initiative, an ongoing primary prevention trial, ...References1. Grodstein F, Manson JE, Colditz GA, Willett WC, Speizer FE, Stampfer MJ. A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease. Ann Intern Med. 2000;133:933-41. [PMID: 11119394] LinkGoogle Scholar2. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, et al . Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA. 1998;280:605-13. [PMID: 9718051] CrossrefMedlineGoogle Scholar3. Herrington DM, Reboussin DM, Brosnihan KB, Sharp PC, Shumaker SA, Snyder TE, et al . Effects of estrogen replacement on the progression of coronary-artery atherosclerosis. N Engl J Med. 2000;343:522-9. [PMID: 10954759] CrossrefMedlineGoogle Scholar4. Blakely JA. The Heart and Estrogen/progestin Replacement Study revisited: hormone replacement therapy produced net harm, consistent with the observational data. Arch Intern Med. 2000;160:2897-900. [PMID: 11041895] CrossrefMedlineGoogle Scholar5. Grady D, Hulley SB. Hormones to prevent coronary disease in women: when are observational studies adequate evidence? [Editorial]. Ann Intern Med. 2000;133:999-1001. [PMID: 11119402] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Munich; D-81377 Munich, Germany PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHormones To Prevent Coronary Disease in Women: When Are Observational Studies Adequate Evidence? Deborah Grady and Stephen B. Hulley A Prospective, Observational Study of Postmenopausal Hormone Therapy and Primary Prevention of Cardiovascular Disease Francine Grodstein , JoAnn E. Manson , Graham A. Colditz , Walter C. Willett , Frank E. Speizer , and Meir J. Stampfer Postmenopausal Hormone Therapy and Cardiovascular Disease Francine Grodstein , JoAnn E. Manson , and Meir J. Stampfer Postmenopausal Hormone Therapy and Cardiovascular Disease Kenneth M. Kessler Metrics Cited byBeneficios percibidos de un grupo de mujeres en climaterio incorporadas a un programa de actividad física terapéuticaWomen's Health LiteratureWatch 18 December 2001Volume 135, Issue 12Page: 1093KeywordsCardiovascular diseasesCardiovascular therapyCoronary heart diseaseEstrogen replacement therapyHeart rateHormone replacement therapyLongitudinal studiesObservational studiesObstetrics and gynecologyRisk management ePublished: 18 December 2001 Issue Published: 18 December 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...