Breaking the Silence on Viral Hepatitis
Authors: Ronald O. Valdiserri, Howard K. Koh
Journal: Annals of Internal Medicine (2014)

Ideas and Opinions15 July 2014Breaking the Silence on Viral HepatitisRonald O. Valdiserri, MD, MPH and Howard K. Koh, MD, MPHRonald O. Valdiserri, MD, MPHFrom U.S. Department of Health and Human Services, Washington, DC. and Howard K. Koh, MD, MPHFrom U.S. Department of Health and Human Services, Washington, DC.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/M14-0404 Annals Author Insight Video - Ronald O. Valdiserri, MD, MPH In this video, Ronald O. Valdiserri, MD, MPH, offers additional insight into his Ideas and Opinions piece, "Breaking the Silence on Viral Hepatitis." SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Until recently, the silent epidemic of viral hepatitis has eluded a unified national public health strategy for controlling morbidity and mortality. Consequently, untreated chronic viral hepatitis affects between 3.5 and 5.3 million Americans and continues to fuel rising rates of progressive liver disease, liver failure, and liver cancer (1). Chronic hepatitis C virus (HCV) infection affects some 2.7 million noninstitutionalized Americans (2), represents the leading indication for liver transplantation in the United States (3), and has caused more deaths annually than HIV since 2007 (4). Although effective vaccination strategies have contributed to a decline in new cases of acute hepatitis ...References1. Institute of Medicine. Hepatitis and Liver Cancer. A National Strategy for Prevention and Control of Hepatitis B and C. Washington, DC: National Academies Pr; 2010. Google Scholar2. Denniston MM, Jiles RB, Drobeniuc J, Klevens M, Ward JW, McQuillan GM, Holmberg SD. Chronic hepatitis C virus infection in the United States, National Health and Nutrition Examination Survey 2003 to 2010. Ann Intern Med. 2014;160:293-300. LinkGoogle Scholar3. Berg CL, Steffick DE, Edwards EB, Heimbach JK, Magee JC, Washburn WK, et al. Liver and intestine transplantation in the United States 1998–2007. Am J Transplant. 2009;9:907-31. [PMID: 19341415] CrossrefMedlineGoogle Scholar4. Ly KN, Xing J, Klevens RM, Jiles RB, Ward JW, Holmberg SD. The increasing burden of mortality from viral hepatitis in the United States between 1999 and 2007. Ann Intern Med. 2012;156:271-8. [PMID: 22351712] LinkGoogle Scholar5. Centers for Disease Control and Prevention. Viral Hepatitis Statistics & Surveillance: Surveillance for Viral Hepatitis–United States, 2011. Atlanta, GA: Centers for Disease Control and Prevention. Accessed at www.cdc.gov/hepatitis/Statistics/2011Surveillance/ on 23 January 2014. Google Scholar6. Combating the Silent Epidemic of Viral Hepatitis: Action Plan for the Prevention, Care, and Treatment of Viral Hepatitis. Washington, DC: U.S. Department of Health and Human Services; 2011. Accessed at www.hhs.gov/ash/initiatives/hepatitis/actionplanviralhepatitis2011.pdf on 23 January 2014. Google Scholar7. Ngo-Metzger Q, Ward JW, Valdiserri RO. Expanded hepatitis C virus screening recommendations promote opportunities for care and cure [Editorial]. Ann Intern Med. 2013;159:364-5. [PMID: 23797155] LinkGoogle Scholar8. Valdiserri RO, Khalsa J, Dan C, Holmberg S, Zibbell J, Holtzman D, et al. Confronting the emerging epidemic of hepatitis C virus among young injection drug users. Am J Public Health. 2014;:e1-6. Google Scholar9. Martin NK, Vickerman P, Grebely J, Hellard M, Hutchinson SJ, Lima VD, et al. Hepatitis C virus treatment for prevention among people who inject drugs: Modeling treatment scale-up in the age of direct-acting antivirals. Hepatology. 2013;58:1598-609. [PMID: 23553643] CrossrefMedlineGoogle Scholar10. Action Plan for the Prevention, Care and Treatment of Viral Hepatitis: Updated, 2014–2016. Washington, DC: U.S. Department of Health and Human Services. Accessed at http://aids.gov/pdf/viral-hepatitis-action-plan.pdf on 4 April 2014. Google Scholar Author, Article, and Disclosure InformationAuthors: Ronald O. Valdiserri, MD, MPH; Howard K. Koh, MD, MPHAffiliations: From U.S. Department of Health and Human Services, Washington, DC.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M14-0404.Corresponding Author: Ronald O. Valdiserri, MD, MPH, U.S. Department of Health and Human Services, 200 Independence Avenue SW, HHH Building, Room 443-H, Washington, DC 20201; e-mail, ron.[email protected]gov.Current Author Addresses: Drs. Valdiserri and Koh: U.S. Department of Health and Human Services, 200 Independence Avenue SW, Washington, DC 20201.Author Contributions: Conception and design: R.O. Valdiserri, H.K. Koh.Drafting of the article: R.O. Valdiserri.Critical revision of the article for important intellectual content: R.O. Valdiserri, H.K. Koh.Final approval of the article: R.O. Valdiserri, H.K. Koh.This article was published online first at www.annals.org on 29 April 2014. PreviousarticleNextarticle Advertisement Annals Author Insight Video - Ronald O. Valdiserri, MD, MPH In this video, Ronald O. Valdiserri, MD, MPH, offers additional insight into his Ideas and Opinions piece, "Breaking the Silence on Viral Hepatitis." FiguresReferencesRelatedDetails Metrics Cited byHealth outcomes and cost-effectiveness of diversion programs for low-level drug offenders: A model-based analysisStructural sensitivity in HIV modeling: A case study of vaccinationNavigating Government Service as a PhysicianEmerging Epidemic of Hepatitis C Virus Infections Among Young Nonurban Persons Who Inject Drugs in the United States, 2006–2012Hepatitis C virus: The 25-year journey from discovery to cure 15 July 2014Volume 161, Issue 2Page: 147-148KeywordsChronic hepatitisDrug abuseDrugsHepatitisHepatitis AHepatitis BHepatitis CMorbidityMortalityPrevention, policy, and public health ePublished: 15 July 2014 Issue Published: 15 July 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...