Lithium and Diabetes Insipidus
Authors: TREVOR R.P. PRICE
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 April 1978Lithium and Diabetes InsipidusTREVOR R.P. PRICE, M.D., PAUL J. BEISSWENGER, M.D.TREVOR R.P. PRICE, M.D., PAUL J. BEISSWENGER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-4-576_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Although mild polyuria (>3 litres/day) and polydipsia are quite common (12% and 40%, respectively) with lithium carbonate therapy (1, 2), nephrogenic diabetes insipidus is an uncommon complication first recognized in the early 1970s (3). In reported cases marked polyuria and polydipsia have variably appeared between the second week and seventh month after the start of therapy and have gradually increased to maximum severity over the next 1 to 3 weeks. The reported cases have generally occurred with nontoxic serum lithium concentrations and have been associated with laboratory evidence of nephrogenic diabetes insipidus, which generally clears within 3...References1. PADFIELDPARKMORTONBRAIDWOOD PSJA: Plasma levels of antidiuretic hormone in patients receiving prolonged lithium therapy. Br J Psychiatry 130:144-147, 1977 CrossrefMedlineGoogle Scholar2. FORRESTCOHENTORRETTIHIMMELHOCHEPSTEIN JAJJF: On the mechanism of lithium-induced diabetes insipidus in man and the rat. J Clin Invest 53:1115-1123, 1974 CrossrefMedlineGoogle Scholar3. ANGRISTGERSHONLEVITANBLUMBERG BSSA: Lithium-induced diabetes insipidus-like syndrome. Compr Psychiatry 11:141-146, 1970 CrossrefMedlineGoogle Scholar4. SIMONGARBERARIEFF NEA: Persistent nephrogenic diabetes insipidus after lithium carbonate. Ann Intern Med 86:446-447, 1977 LinkGoogle Scholar5. HAGHFELTLUNDJØRGENSENBAASTRUP TJHP: [Lithium poisoning and renal function.] (Nor.) Nord Med 86:1465-1471, 1971 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Mary Hitchcock Memorial Hospital Hanover, NH 03755 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNephrotoxicity of Lithium and Drugs of AbuseNephrotoxicity of Lithium and Drugs of AbuseLithium-associated kidney effectsLithium-induced renal effectsNephrogenic Diabetes Insipidus Persisting 57 Months after Cessation of Lithium Carbonate Therapy: Report of a Case and Review of the LiteratureLithium and the kidneyDrug-Induced Renal DisordersPersistent nephrogenic diabetes insipidus, tubular proteinuria, aminoaciduria, and parathyroid hormone resistance following longterm lithium administration.Prevalence, Pathogenesis, and Treatment of Renal Dysfunction Associated With Chronic Lithium TherapyLithium and impairment of renal concentrating abilityCUTANEOUS MANIFESTATIONS OF LITHIUM TOXICITYLithium and the kidneyLithiumEffects of lithium on the kidneyRenal Side-Effects of LithiumAt the research front: Lithium Prophylaxis: Is the Honeymoon Over? 1 April 1978Volume 88, Issue 4Page: 576-577KeywordsAttentionCarbonatesResearch laboratories Issue Published: 1 April 1978 PDF downloadLoading ...