tbuckley/cabot-search huggingface dataset:
Abstract 3337: Characterization of tumor initiating cells response to chemotherapy in human colorectal cancer
Authors: Victoria da Silva-Diz, Diana Riba-Artés, Mireia Gausachs, María Urpí, Gabriel Capella, Ramón Salazar, Alberto Villanueva, Purificación Muñoz
Journal: Cancer Research (2010)

Abstract Current chemotherapy for colorectal cancer is still based in combined 5-fluorouracil (5-FU) and oxaliplatin administration with or without other new drugs. However, an important percentage of patients show resistance to this treatment. Tumor initiating cells (TICs) or cancer stem cells, are able to reconstitute a tumor of similar characteristics to the primary tumor after transplantation into immunodeficient mice. TICs show the ability to self-renew and give rise to non-TIC progeny, supporting the tumor growth. Recent studies suggest that TICs may be intrinsically resistant to therapy, leading to tumor relapse after chemotherapy. To gain insight into the dynamics of TICs during tumor progression and in response to chemotherapy, we have orthotopically implanted and perpetuated in nude mice 14 human colorectal carcinomas (CRC) that produce local and distal dissemination. We have characterized the chemotherapy response in 7 of these perpetuated xenografts. Four of these tumors showed a significant reduction of growth after 5-FU and oxaliplatin combined treatment (FUOX treatment) compared to the correspondent non-treated control tumors. To evaluate the role of TICs in chemotherapy response, we analyzed survival of non-TICs and TICs -identified by CD133/CD44/EpCAM cell surface markers- after chemotherapy. Our results show that, although in 2 out of 4 of the tumors showing efficient response to chemotherapy, TICs were more resistant to FUOX than the rest of tumor cells, in the other 2 tumors TICs and non-TICs were similarly sensitive to treatment. These results indicate that the resistance to chemotherapy is not an intrinsic characteristic of TICs and offer the possibility to characterize sensitive and resistant TICs to FUOX to identify genes and pathways directly involved in chemoresistance. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3337.
Physiologic and rheologic effects of the antisickling agent ethacrynic acid and its N‐butylated derivative on normal and sickle erythrocytes
Authors: Eugene P. Orringer, David S. Blythe, James A. Whitney, Scott Brockenbrough, Donald J. Abraham
Journal: American Journal of Hematology (1992)

Abstract Ethacrynic acid, a loop diuretic, has been shown to inhibit hemoglobin S polymerization. Until now, however, most studies were performed using purified solutions of hemoglobin S. The experiments reported here were designed to examine the effects of ethacrynic acid and its n‐butryic acid derivative on the rheological and physiological properties of intact red blood cells. Using net and unidirectional flux measurements, both agents were shown to cause ion and water loss from normal and sickle erythrocytes. Since cell shrinkage adversely influences red cell rheology, it is unlikely that this class of compounds, despite its ability to inhibit hemoglobin S polymerization, will prove useful in the treatment of sickle cell disease.
Cancer expert attacks drug company's funding of research paper
Authors: Caroline White
Journal: BMJ (2007)

A leading cancer epidemiologist has heavily criticised the funding and science of a report that compares different rates of cancer survival in 25 countries. The report linked cancer survival with access to new and innovative drugs.

The Karolinska 2 report, published earlier this year in the Annals of Oncology , concluded that access to cancer drugs affected survival and that the licensing process should be speeded up, with equitable access for all (2007;18(suppl 3):iii2-7).

But the epidemiologist Michel Coleman, who heads the cancer survival group of Cancer Research UK, has in the latest issue of the …
Antipenicillinase Activity of a New Synthetic Penicillin—Potassium α-Phenoxyethyl Penicillin.
Authors: B. A. Waisbren
Journal: Annals of Internal Medicine (1961)

s1 May 1961Antipenicillinase Activity of a New Synthetic Penicillin—Potassium α-Phenoxyethyl Penicillin.B. A. Waisbren, M.D., F.A.C.P.B. A. Waisbren, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-5-1058_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe fact that penicillin resistance of staphylococci is mediated through the production of the enzyme penicillinase rather than by the resistance of a vital enzyme system has led to many attempts to inhibit penicillinase so as to allow penicillin to destroy the still susceptible staphylococci. The antipenicillinase sera of Housewright and Henry failed in this regard because intracellular penicillinase apparently was not reached and destroyed.Total synthesis of penicillin by Sheehan and Henery-Logan suggested the possibility that substances could be synthesized that would have the antibacterial activity of penicillin but that would be resistant to the action of penicillinase.The... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Milwaukee, Wis. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1961Volume 54, Issue 5Page: 1058-1058KeywordsEnzymesPenicillin ePublished: 1 December 2008 Issue Published: 1 May 1961 PDF downloadLoading ...
Subncute cutaneous lupus erythematosus-like gyrate erythema and hypertrichosis lanuginosa acquisita associated with uterine adenocarcinoma
Authors: K.E. McKenna, D. Hyes, J.C. McMililan
Journal: British Journal of Dermatology (1992)

Journal Article Subncute cutaneous lupus erythematosus‐like gyrate erythema and hypertrichosis lanuginosa acquisita associated with uterine adenocarcinoma Get access K.E. McKenna, K.E. McKenna Department of Dermatology Search for other works by this author on: Oxford Academic Google Scholar D. Hyes, D. Hyes Pathology, Bulfast Citil Hospital, Belfast BT9 7AB, Northern Ireland. Search for other works by this author on: Oxford Academic Google Scholar J.C. McMililan J.C. McMililan Department of Dermatology Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 127, Issue 4, 1 October 1992, Pages 443–444, https://doi.org/10.1111/j.1365-2133.1992.tb00468.x Published: 01 October 1992
TRANSCATHETER CLOSURE OF SECUNDUM ATRIAL SEPTAL DEFECT WITH DEFICIENT RIMS OTHER THAN THE ANTERO SUPERIOR USING AMPLATZER DEVICES
Authors: Alain Fraisse, Anass Assaidi, Issam Kammache, Julien Mancini, Phlippe Aldebert, Debora Luciano, Caroline Ovaert, Nicolas Michel, Gilbert Habib
Journal: Journal of the American College of Cardiology (2013)
Nosocomial Infection with Klebsiella Type 25
Authors: Alfred J. Weil, Subash Ramchand, Marcelo E. Arias
Journal: New England Journal of Medicine (1966)

THE organisms of the klebsiella-aerobacter-serratia group (in the following discussion called KAS group, in accordance with current nomenclature1 2 3) are constituents of the normal enteric flora of man. Like the other enterobacteriaceae, they are also opportunistic pathogens and are thus frequently found in urinary-tract infections, peritonitis and infected wounds and — less commonly — in pneumonia, empyema, meningitis and septicemic infections.3 4 5 6 7 8 9 The incidence of severe infections of this kind has probably increased rather than diminished in recent years. This was pointed out by Finland and his co-workers,10 who raised the question whether this may not be related to the resistance . . .
Competence: What's in? What's out? Who knows?
Authors: Joshua Alexander, Ronald Mallon, Jonathan M. Weinberg
Journal: Behavioral and Brain Sciences (2010)

Abstract Knobe's argument rests on a way of distinguishing performance errors from the competencies that delimit our cognitive architecture. We argue that other sorts of evidence than those that he appeals to are needed to illuminate the boundaries of our folk capacities in ways that would support his conclusions.
Effect of Arsenic Exposure during Pregnancy on Infant Development at 7 Months in Rural Matlab, Bangladesh
Authors: Fahmida Tofail, Marie Vahter, Jena D. Hamadani, Barbro Nermell, Syed N. Huda, Mohammad Yunus, Mahfuzar Rahman, Sally M. Grantham-McGregor
Journal: Environmental Health Perspectives (2008)

BackgroundExposure to arsenic-contaminated drinking water during pregnancy is associated with low birth weight and fetal loss, and there is concern that the infants' development may be affected.ObjectiveWe assessed the effects of in utero arsenic exposure during pregnancy on infants' problem-solving ability and motor development.MethodsWe conducted a large population-based study of nutritional supplementation with 4,436 pregnant women in Matlab, Bangladesh, an area of high-arsenic–contaminated tube wells. We measured arsenic concentration in spot urine specimens at 8 and 30 weeks of pregnancy. We assessed a subsample of 1,799 infants, born to these mothers, at 7 months of age on two problem-solving tests (PSTs), the motor scale of the Bayley Scales of Infant Development–II, and behavior ratings.ResultArsenic concentrations in maternal urine were high, with a median (interquartile range) of 81 μg/L (37–207 μg/L) at 8 weeks of gestation and of 84 μg/L (42–230 μg/L) at 30 weeks. Arsenic exposure was related to many poor socioeconomic conditions that also correlated with child development measures. Multiple regressions of children's motor and PST scores and behavior ratings, controlling for socioeconomic background variables, age, and sex, showed no significant effect of urinary arsenic concentration on any developmental outcome.ConclusionWe detected no significant effect of arsenic exposure during pregnancy on infant development. However, it is possible that other effects are as yet unmeasured or that effects will become apparent at a later age.
Extending Simulation Learning Experiences to Patients With Chronic Health Conditions
Authors: Eric A. Coleman
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Do silicone breast implants cause connective tissue disease?
Authors: C. Coope, E. Dennison
Journal: BMJ (1998)

Few more controversial issues exist in modern rheumatology than the putative association between silicone breast implants and systemic connective tissue disease. The term silicone refers to a family of chemically related organic silicon compounds derived from silica (SiO2). Small quantities of silicone are found in joint prostheses, artificial heart valves, and baby bottle nipples, but the major medical use of the fluid compound, polydimethyl siloxane, is in implants. Silicone breast implants were developed in 1962 and are used mainly for cosmetic augmentation (80%) and reconstruction after surgery for breast cancer.1 By 1992, 1-2.5 million women had received such implants in north America,2 and 100 000–150 000 British women are currently estimated to have them. Silicone implants have been associated with hardening (thought to be due in part to leakage), occasional rupture, and enlargement of lymph nodes draining the implant site.3 It is the possible link with systemic connective tissue diseases, however, that has fuelled an acrimonious medical, regulatory, and legal debate.

Although the first report of a connective tissue disease after direct injection of silicone into the breast dates from 1964,4 the first three patients with silicone implants who developed these disorders were documented in 1982.2 …
Role of a NK receptor, KLRE-1, in bone marrow allograft rejection: analysis with KLRE-1–deficient mice
Authors: Eiko Shimizu, Junzo Koike, Hiroshi Wakao, Ken-ichiro Seino, Haruhiko Koseki, Terutaka Kakiuchi, Toshinori Nakayama, Masaru Taniguchi
Journal: Blood (2004)
Surgical castration for sex offenders: Mr K's wish granted
Authors: S R Silcock, A Clarke, P Rowe, N Black
Journal: BMJ (1994)

EDITOR, - Philip Joseph suggests that Mr K was merely bluffing in requesting that he should be castrated.1 Unless there are two such cases under debate, according to the Observer the man has had his operation at a private clinic in the south of England.2 If the report is reliable and refers to the same person, what will now be interesting is clinical follow …
Influence of peripheral intravenous contrast injection on the QRS complex in healthy men
Authors: K. ISHIKAWA, S. KANAMARU, M. YOTSUKURA, T. TSUYA, C. SHIRATO, A. YANAGISAWA
Journal: Cardiovascular Research (1986)

The influence of acute plasma expansion induced by the administration of sodium containing hyperosmolar contrast medium on Frank lead electrocardiograms was investigated in 10 healthy male volunteers. The major electrocardiographic changes after injection of the contrast medium were a significant decrease in the amplitudes of Rx, Ry, and Qz and the maximal spatial QRS voltage, and a significant increase in the amplitude of Sx. The echocardiographic left ventricular end diastolic dimension tended to be larger after the injection, whereas no significant change occurred in the left ventricular systolic dimension. The electrocardiographic changes in this study were the opposite of those expected with the Brody effect. Although the precise mechanism underlying these findings is unclear, the increased intracardiac blood volume may have caused a decrease in the QRS voltage by a short circuiting effect. Alternatively if the activation in the left ventricle is assumed to be predominantly tangential the QRS voltage should have decreased with the Brody effect. The Brody effect may lead to an erroneous interpretation of electrocardiograms in certain clinical settings.
Folic-acid Deficiency in Rheumatoid Arthritis: Relation of Levels of Serum Folic-acid Activity of Treatment with Phenylbutazone
Authors: D. J. Deller, E. Urban, R. N. Ibbotson, J. Horwood, S. Milazzo, H. N. Robson
Journal: BMJ (1966)

However, as a group the levels of patients with rheumatoid arthritis were significantly lower than those of the normal subjects.
Restlessness With Renal Colic
Authors: C. Jay Hoyt
Journal: JAMA (1971)

<h3>To the Editor.—</h3> I was interested in the discussion of restlessness in patients with renal colic in theQUESTIONSANDAnswerssection (<b>216</b>:-527,1971). As a resident in a large general hospital emergency room many years ago, I was impressed by three patients seen in a short period of time who not only exhibited the restlessness described, but also exhibited a characteristic posture. This consisted of the patient standing at the bedside, flexed 90° at the hips, and with his trunk resting prone on the bed. Each patient insisted on maintaining this position and could not be persuaded to get into bed. The position was so characteristic that in the case of the third patient the correct diagnosis of renal colic was made on initial inspection at the distance of 30 feet.
Follow-Up of Selective Endoscopic Ultrasonography and/or Endoscopic Retrograde Cholangiography Prior to Laparoscopic Cholecystectomy: A Prospective Study of 300 Patients
Authors: S. V. Berdah, P. Orsoni, T. Bege, M. Barthet, J.-C. Grimaud, R. Picaud
Journal: Endoscopy (2001)

Background and Study Aims: This prospective study evaluated the selective use of endoscopic retrograde cholangiography (ERC) and endoscopic ultrasonography (EUS) in the context of laparoscopic cholecystectomy (LC).
The performance of laminin-containing cryogel scaffolds in neural tissue regeneration
Authors: Marcin Jurga, Maria B. Dainiak, Anna Sarnowska, Anna Jablonska, Anuj Tripathi, Fatima M. Plieva, Irina N. Savina, Lukasz Strojek, Hans Jungvid, Ashok Kumar, Barbara Lukomska, Krystyna Domanska-Janik, Nico Forraz, Colin P. McGuckin
Journal: Biomaterials (2011)
99mTc-Anti-TNF-α Scintigraphy
Authors: Flávia Paiva Proença Lobo Lopes, Sergio Augusto Lopes de Souza, Patrícia de Fátima dos Santos Teixeira, Elisa dos Santos Rebelo Pinho, Lea Mirian Barbosa da Fonseca, Mario Vaisman, Bianca Gutfilen
Journal: Clinical Nuclear Medicine (2012)

Different imaging methods applied in the evaluation of a patient with unilateral active Graves ophthalmopathy (GO) are shown in the present paper. 99mTc-Anti-TNF-α scintigraphy is proposed as a promising method, not yet described, for the diagnosis of active ocular disease. It consists of labeling a human monoclonal antibody directed against TNF-α molecule (adalimumab) with technetium (99mTc). The method is based on the demonstration of TNF-α as one of the cytokines enrolled in the initial active phase of GO development. The method may give the perspective to link diagnosis and therapy, including new target-based modalities.
Chemokine Expression From Oncolytic Vaccinia Virus Enhances Vaccine Therapies of Cancer
Authors: Jun Li, Mark O'Malley, Julie Urban, Padma Sampath, Z Sheng Guo, Pawel Kalinski, Steve H Thorne, David L Bartlett
Journal: Molecular Therapy (2011)

Tumor vaccines can induce robust immune responses targeting tumor antigens in the clinic, but antitumor effects have been disappointing. One reason for this is ineffective tumor infiltration of the cytotoxic T lymphocytes (CTLs) produced. Oncolytic viruses are capable of selectively replicating within tumor tissue and can induce a strong immune response. We therefore sought to determine whether these therapies could be rationally combined such that modulation of the tumor microenvironment by the viral therapy could help direct beneficial CTLs induced by the vaccine. As such, we examined the effects of expressing chemokines from oncolytic vaccinia virus, including CCL5 (RANTES), whose receptors are expressed on CTLs induced by different vaccines, including type-1-polarized dendritic cells (DC1). vvCCL5, an oncolytic vaccinia virus expressing CCL5, induced chemotaxis of lymphocyte populations in vitro and in vivo, and displayed improved safety in vivo. Interestingly, enhanced therapeutic benefits with vvCCL5 in vivo correlated with increased persistence of the viral agent exclusively within the tumor. When tumor-bearing mice were both vaccinated with DC1 and treated with vvCCL5 a further significant enhancement in tumor response was achieved which correlated with increased levels of tumor infiltrating lymphocytes. This approach therefore represents a novel means of combining biological therapies for cancer treatment. Tumor vaccines can induce robust immune responses targeting tumor antigens in the clinic, but antitumor effects have been disappointing. One reason for this is ineffective tumor infiltration of the cytotoxic T lymphocytes (CTLs) produced. Oncolytic viruses are capable of selectively replicating within tumor tissue and can induce a strong immune response. We therefore sought to determine whether these therapies could be rationally combined such that modulation of the tumor microenvironment by the viral therapy could help direct beneficial CTLs induced by the vaccine. As such, we examined the effects of expressing chemokines from oncolytic vaccinia virus, including CCL5 (RANTES), whose receptors are expressed on CTLs induced by different vaccines, including type-1-polarized dendritic cells (DC1). vvCCL5, an oncolytic vaccinia virus expressing CCL5, induced chemotaxis of lymphocyte populations in vitro and in vivo, and displayed improved safety in vivo. Interestingly, enhanced therapeutic benefits with vvCCL5 in vivo correlated with increased persistence of the viral agent exclusively within the tumor. When tumor-bearing mice were both vaccinated with DC1 and treated with vvCCL5 a further significant enhancement in tumor response was achieved which correlated with increased levels of tumor infiltrating lymphocytes. This approach therefore represents a novel means of combining biological therapies for cancer treatment.
Confocal laser scanning fluorescence microscopy for in vivo determination of microvessel density in Barrett’s esophagus
Authors: V. Becker, M. Vieth, M. Bajbouj, R. Schmid, A. Meining
Journal: Endoscopy (2008)

See also: Commentaire de travail de V. Becker et al., pp. 888Endoscopy 2008; 40(11): 1057-1057DOI: 10.1055/s-0032-1306883
Endothelial cells express an alpha-melanocyte-stimulating hormone-like immunoreactivity in prurigo nodularis
Authors: Y. Liang, L. Emtestam, O. Johansson
Journal: British Journal of Dermatology (2001)

Sir, In 1880, Hardaway reported a skin disease characterized by multiple tumours associated with marked pruritus,1 which was named prurigo nodularis by Hyde in 1909.2 The individual lesion is a hard, globular, erythematous nodule characterized by intense itching. It is usually 1–3 cm in diameter, has a verrucous surface, and is found over the extensor surfaces of the extremities. It most often begins in middle age, has a long‐lasting duration, and affects women more commonly than men.3 Many patients have a personal or family history of atopy.4 Histologically, the disease is characterized by irregular acanthosis, hyperkeratosis, an inflammatory cell infiltrate and, especially, massive neural hyperplasia. The neurohistological changes have been verified by staining with certain neuronal markers.5,6 In our previous studies, we have, in addition, found that in the disease the Schwann cell membrane mainly expresses p75 nerve growth factor (NGF) receptor.7 Numbers of eosinophils and histamine‐containing mast cells were significantly increased in the lesional upper dermis in prurigo nodularis. Both cell types were seen in close vicinity to nerve fibres and sometimes appeared to contact single nerve fibres.8–10
AMA Gets Goethe Trophy for Antismoking Efforts
Authors: Andrew A. Skolnick
Journal: JAMA (1996)

WHILE the German writer Johann Wolfgang von Goethe (1749-1832) is renowned for his<i>Faust</i>and other literary works, few people know that he was an ardent crusader against active and passive smoking. The establishment of the Goethe Challenge Trophy, presented this year to the American Medical Association (AMA) for its leadership in the war against the tobacco pandemic, has focused attention on that obscure aspect of the poet-philosopher's multiple interests. At a ceremony in October at AMA headquarters in Chicago, Ill, Frank Montgomery, MD, vice president of the German Medical Association, presented the trophy—a 42-lb silver bust of Goethe—to the Association along with a framed citation. "This trophy was commissioned to be awarded annually to an institution that has excelled in promoting a smoke-free environment, especially among health care professionals, thus making an example for society at large," he said. The Goethe Challenge Trophy was established by Friedrich Portheine, MD,