tbuckley/cabot-search huggingface dataset:
Abstract 2689: XAGE-1b(GAGED2a) immunity in non-small cell lung cancer
Authors: Yoshihiro Ohue, Shingo Eikawa, Hirofumi Matsumoto, Yu Mizote, Midori Isobe, Akiko Uenaka, Minoru Fukuda, Eiichi Nakayama, Mikio Oka
Journal: Cancer Research (2011)

Abstract BACKGROUND: Several cancer/testis(CT) antigens such as NY-ESO-1 antigen, etc., have been shown to elicit immune responses in cancer patients spontaneously. Because of their restricted expression in normal tissues and high immunogenicity, CT antigens have been thought to be attractive targets for cancer vaccine. We previously described XAGE-1b (GAGED2a), one of the CT-associated antigens, was predominantly expressed in lung adenocarcinoma by immunohistochemistry using XAGE-1b mAb (clone USO 9-13) and could elicit both humoral and cellular immune response in patients with non-small cell lung cancer (NSCLC). In this study, we established CD4 and CD8 T cell clones from PBMC in XAGE-1b antibody-positive patients and analyzed the antigen recognition. MATERIALS AND METHODS: Sera and PBMCs were obtained from NSCLC patients who visited Kawasaki Medical School Hospital between 2005 and 2010. Antibody response to XAGE-1b was analyzed by ELISA using synthesized XAGE-1b protein. CD4 and CD8 T cell responses against XAGE-1b were examined by IFN-γ ELISA and/or capture assay using 17 16- or 17-mer XAGE-1b-overlapping peptides (OLPs) spanning the entire XAGE-1b protein by FACS in antibody-positive patients. Cytotoxicity was analyzed by bioluminescence assay (GAPDH). RESULTS: Spontaneous CD4 and CD8 T cell responses were also detected in most of the antibody positive patients. Occurrence of antibody response, and CD4 and CD8 T cell responses in XAGE-1b (GAGED2a) antibody positive patients indicated strong immunogenicity of XAGE-1b (GAGED2a) antigen in NSCLC patients. Furthermore, We identified the minimal epitope peptide bound to HLA-DR4.1 and DP5 recognized by CD4 and those bound to HLA-A2, B61 and Cw1 recognized by CD8 T cell clones. CD4 and CD8 T cell clones recognized naturally processed XAGE-1b (GAGED2a) antigen on APC (antigen-presenting cell) and the CD8 T cell clone was stained with the peptide/MHCI tetramer and showed cytotoxicity against XAGE-1b (GAGED2a)-expressing, appropriate HLA class I expressing tumor cell line. CONCLUSION: Our findings indicate validity of XAGE-1b (GAGED2a) for cancer vaccine. Now we plan to global clinical trial of cancer vaccine against XAGE-1b in NSCLC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2689. doi:10.1158/1538-7445.AM2011-2689
The Frequency of the Rheumatic Diseases
Authors: P. H. N. Wood
Journal: Annals of the Rheumatic Diseases (1972)

Recognizing that uncritical bibliographical surveys are useless, Cobb essays an interpretative review of epidemio- logical data on rheumatic complaints and the principal individual diseases, rheumatoid arthritis, osteoarthrosis, ankylosing spondylitis, gout, Still's disease, and connective tissue disorders.Much valuable material is considered, and in a commendably brief presentation.However, it is regrettable that those leaders in the morbidity statistics, soft-tissue rheumatism and pain in the back, receive only
Calcium balance in chronic kidney disease: walking the tightrope
Authors: Pieter Evenepoel, Liesbeth Viaene, Bjorn Meijers
Journal: Kidney International (2012)

Calcium supplements for prevention and treatment of mineral and bone disorders in chronic kidney disease (CKD) have been alternately praised and damned. Clinical evidence in favor of either attitude has been lacking. The calcium balance study by Spiegel and Brady in patients with late stage 3 and stage 4 CKD suggests that CKD subjects ingesting 2000 mg of elemental calcium per day are in marked positive balance. Methodological limitations such as unproven steady state warrant caution and confirmatory studies.
Therapeutic depletion of myeloid lineage leukocytes in patients with generalized pustular psoriasis indicates a major role for neutrophils in the immunopathogenesis of psoriasis
Authors: Shigaku Ikeda, Hidetoshi Takahashi, Yasushi Suga, Hikaru Eto, Takafumi Etoh, Keiko Okuma, Kazuo Takahashi, Takeshi Kanbara, Mariko Seishima, Akimichi Morita, Yasutomo Imai, Takuro Kanekura
Journal: Journal of the American Academy of Dermatology (2013)
Mechanisms of angiogenesis and remodelling of the microvasculature
Authors: J.-S. Silvestre, B. I. Levy, A. Tedgui
Journal: Cardiovascular Research (2008)

The development of blood vessels is essential for organ growth in the embryo and repair of wounded tissue in the adult. However, an imbalance in this process contributes to the pathogenesis of a number of disorders including cancer that is now recognized as the result of not only uncontrolled malignant cell proliferation but also uncontrolled vessel growth. The existence of tumour-derived factors responsible for promoting new vessel growth was postulated over 70 years ago, and a few years later, it was proposed that tumour growth is crucially dependent on neovascular supply. In 1971, pioneering work by Judah Folkmann, who sadly passed away on 14 January 2008, suggested that inhibition of angiogenesis would be an effective strategy to treat human cancer, leading to the development of an active search for angiogenesis inducers and inhibitors. In less than 15 years, an explosion of interest in angiogenesis research has generated the necessary insights to develop the first clinically approved anti-angiogenic agents.1 Several additional common disorders such as psoriasis, arthritis, blindness, obesity, asthma, atherosclerosis, and infectious disease are associated with excessive angiogenesis.2

Alternatively, insufficient vessel growth and abnormal vessel regression can lead to ischaemic diseases as well as to neurodegeneration, hypertension, pre-eclampsia, respiratory distress, osteoporosis, and other disorders. Over the past decade, intensive efforts have also been undertaken to develop therapeutic strategies to promote revascularization of ischaemic tissues. Unfortunately, clinical trials testing the pro-angiogenic potential of vascular endothelial growth factor (VEGF) or fibroblast growth factor (FGF) failed to demonstrate any beneficial effects. Novel strategies, involving transplantation … 

*Corresponding author. Tel: +33 153216702; fax: +33 142813128. E-mail address : jean-sebastien.silvestre{at}larib.inserm.fr
THE DISTRIBUTION OF FRIEDLÄNDER'S BACILLI OF DIFFERENT TYPES
Authors: Louis A. Julianelle
Journal: The Journal of Experimental Medicine (1930)

In a study of the distribution of the specific types of Friedländer's bacillus, it is shown that: (1) Of 80 strains 52 per cent belong to Type A, 15 per cent to Type B, 9 per cent to Type C, and 24 per cent to Group X. (2) Type A contains for the most part strains derived from diseases of man and more than 70 per cent are associated with pneumonia in man. (3) Type B includes the greatest number of strains from animal sources, while the heterogeneous strains comprising Group X come from the greatest variety of diseases. It was demonstrated that in a patient suffering with pneumonia due to Friedländer's bacillus (Type A), a specific precipitin reaction of the urine occurred in the corresponding (Type A) immune serum. A study of the sugar fermentation reactions of Friedländer's bacillus shows that (1) there is no correlation between serological type and fermentative activity; (2) the fermentation reactions are variable and therefore not reliable for distinguishing Friedländer's bacillus from closely allied organisms; (3) the strains of Group X show the greatest variation in fermentation, and (4) of 15 strains unable to ferment lactose, 13 belong to Type A.
HOW TO PRESENT A SCIENTIFIC PAPER BEFORE A LARGE AUDIENCE
Authors: RICHARD A. KERN
Journal: Annals of Internal Medicine (1952)

Editorial1 September 1952HOW TO PRESENT A SCIENTIFIC PAPER BEFORE A LARGE AUDIENCERICHARD A. KERN, M.D., F.A.C.P.RICHARD A. KERN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-3-618 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe meetings of many medical societies now provide an audience that can number in the thousands, thanks to modern methods of voice amplification and visual projection. Such large audiences attract essayists whose work has won them high rank in their chosen field. Their names on programs, in turn, attract yet larger numbers. Unfortunately, a man who is top-flight as a scientist may nevertheless be most ineffectual on the lecture platform, usually because he makes some simple but crucial mistakes in his manner of presentation. Yet every such mistake is easily avoidable. On the basis of what this writer has suffered... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: American College of Physicians PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPreparing for Oral Scientific and Clinical Vignette PresentationsThe 10-Minute Oral Presentation: What Should I Focus on?How to write an abstract and present it at the annual meetingPresentations at the Annual Meeting 1 September 1952Volume 37, Issue 3Page: 618-624KeywordsScientists Issue Published: 1 September 1952 PDF DownloadLoading ...
The relative importance of arterial remodeling compared with intimal hyperplasia in lumen renarrowing after balloon angioplasty. A study in the normal rabbit and the hypercholesterolemic Yucatan micropig.
Authors: M J Post, C Borst, R E Kuntz
Journal: Circulation (1994)

BACKGROUND Although arterial renarrowing after angioplasty has been attributed largely to intimal hyperplasia, there has been no systematic effort to correlate the actual hyperplastic tissue mass with angiographic lumen reduction. Using balloon angioplasty in various animal restenosis models, we quantitatively assessed the separate contributions of intimal hyperplasia and arterial remodeling to angiographic late lumen loss. METHODS AND RESULTS Data used for this study were obtained from experiments of conventional and thermal (37 degrees C or 55 degrees to 90 degrees C) balloon angioplasty-treated femoral and iliac arteries in normal rabbits and conventional balloon angioplasty-treated iliac arteries in Yucatan micropigs fed either a normal or an atherogenic diet. Quantitative angiography was performed immediately before and after intervention and at 3 or 8 weeks thereafter, and late loss in lumen diameter was taken as the difference between arterial diameter immediately after treatment and at 3 or 8 weeks of follow-up. Intimal hyperplasia was quantified histologically as the area of tissue mass within the internal elastic lamina. We observed a consistent discrepancy between the actual late loss seen with angiography and the diameter reduction that could be explained by histological intimal thickness alone in both animal models. This discrepancy ranged from 86 +/- 3% of the late loss in the 8 weeks/37 degrees C group to 77 +/- 22% in the conventional group for rabbits and 52 +/- 23% in an atherogenic diet group (n = 10) to 89 +/- 11% in a normal diet group (n = 6) for pigs. This discrepancy appeared to be due predominantly to reduction of the area circumscribed by the internal elastic membrane, a process that is tentatively designated as arterial remodeling. In both the rabbit femoral artery and in the Yucatan iliac artery, remodeling, not intimal hyperplasia, correlated with angiographic late loss. CONCLUSIONS In both the normal rabbit and the normal and atherosclerotic pig, restenosis after angioplasty results from both intimal hyperplasia and arterial remodeling. The exact etiology of arterial renarrowing after angioplasty has important implications on the design of antirestenosis drugs and new coronary devices.
NUCLEAR INCLUSIONS IN THE TESTICLES OF MONKEYS INJECTED WITH THE TISSUE OF HUMAN VARICELLA LESIONS
Authors: Thomas M. Rivers
Journal: The Journal of Experimental Medicine (1926)

Eosin-staining nuclear inclusions resembling those deemed characteristic of a certain well known group of filterable viruses, amongst which is varicella, were found in vervets' testicles inoculated with emulsified tissue of human varicella lesions.
Costimulation by B7 Modulates Specificity of Cytotoxic T Lymphocytes: A Missing Link That Explains Some Bystander T Cell Activation
Authors: Pan Zheng, Yang Liu
Journal: The Journal of Experimental Medicine (1997)

It has been proposed that some bystander T cell activation may in fact be due to T cell antigen receptor (TCR) cross-reactivity that is too low to be detected by the effector cytotoxic T lymphocyte (CTL). However, this hypothesis is not supported by direct evidence since no TCR ligand is known to induce T cell proliferation and differentiation without being recognized by the effector CTL. Here we report that transgenic T cells expressing a T cell receptor to influenza virus A/NT/68 nucleoprotein (NP) 366-374:Db complexes clonally expand and become effector CTLs in response to homologous peptides from either A/PR8/34 (H1N1), A/AA/60 (H2N2), or A/NT/68 (H3N2). However, the effector T cells induced by each of the three peptides kill target cells pulsed with NP peptides from the H3N2 and H2N2 viruses, but not from the H1N1 virus. Thus, NP366–374 from influenza virus H1N1 is the first TCR ligand that can induce T cell proliferation and differentiation without being recognized by CTLs. Since induction of T cell proliferation was mediated by antigen-presenting cells that express costimulatory molecules such as B7, we investigated if cytolysis of H1N1 NP peptide–pulsed targets can be restored by expressing B7-1 on the target cells. Our results revealed that this is the case. These data demonstrated that costimulatory molecule B7 modulates antigen specificity of CTLs, and provides a missing link that explains some of the bystander T cell activation.
Predictive Adaptive Responses to Maternal High-Fat Diet Prevent Endothelial Dysfunction but Not Hypertension in Adult Rat Offspring
Authors: Imran Khan, Vasia Dekou, Mark Hanson, Lucilla Poston, Paul Taylor
Journal: Circulation (2004)

Population-based studies suggest that fetal adaptive responses to maternal dietary imbalance confer survival benefit when the postnatal diet remains suboptimal but increase susceptibility to cardiovascular disease when postnatal nutrition is improved. We have investigated "predictive adaptive" responses in a rodent model in which adult offspring of fat-fed dams develop characteristics of the metabolic syndrome.Sprague-Dawley rats were fed a fat-rich diet or normal chow throughout pregnancy and weaning. Vascular endothelial function and blood pressure were determined in 180-day-old offspring of fat-fed dams raised on standard chow (FC) or on the fat-rich diet (FF) and in offspring of chow-fed dams raised on chow (CON). Small mesenteric artery endothelium-dependent dilation to acetylcholine was impaired in male and female FC (by ANOVA, P<0.001 versus CON) but similar to CON in FF (P=NS). Blood glucose was lower in FF versus FC. Heart rate was reduced in male FC versus CON (P<0.05) but not in FF. Plasma triglyceride concentrations were reduced in male FF compared with CON (P<0.05). Blood pressure was raised in female FC (systolic, 132.5+/-3.0 mm Hg versus CON, 119.0+/-3.8 mm Hg, P<0.05; diastolic, 91.2+/-1.7 mm Hg versus CON, 81.1+/-1.4 mm Hg, P<0.05) and in female FF (systolic, 132.5+/-4.2 mm Hg versus CON, P<0.05; diastolic, 91.0+/-1.9 mm Hg versus CON, P<0.05). Blood pressure was similar to CON in male FC and FF.Predictive adaptive responses prevent endothelial dysfunction and reduced heart rate in offspring of fat-fed dams if offspring are raised on the same diet but do not prevent development of raised blood pressure.
Oxypurine cycle in human erythrocytes regulated by pH, inorganic phosphate, and oxygen.
Authors: P A Berman, D A Black, L Human, E H Harley
Journal: Journal of Clinical Investigation (1988)

The effect of pH, PO2, and inorganic phosphate on the uptake and metabolism of hypoxanthine by erythrocytes has been studied. Uptake of hypoxanthine and accumulation of inosine 5'-monophosphate (IMP) were markedly increased at acid pH, high external phosphate concentrations, and low PO2. Release of accumulated IMP as hypoxanthine occurred at alkaline pH values and low external phosphate concentrations. Conditions favoring IMP accumulation gave rise, in the absence of hypoxanthine, to a corresponding increase in 5'-phosphoribosyl-1-pyrophosphate. Intracellular phosphate concentrations were markedly pH dependent and a model is presented whereby hypoxanthine uptake and release are controlled by intracellular concentrations of inorganic phosphate and 2,3-bisphosphoglycerate. These allosteric effectors influence, in opposing ways, two enzymes governing IMP accumulation, namely 5'-phosphoribosyl-1-pyrophosphate synthetase and 5'-nucleotidase. These metabolic properties suggest that the erythrocyte could play a role in the removal of hypoxanthine from anoxic tissue.
1000 INDOCYANINE GREEN FLUORESCENCE INTRAOPERATIVE DETECTION: TOWARD A HIGHER CONCEPT OF SURGICAL RADICALITY
Authors: A. Peloso, M.C. Canepa, L. Barbieri, E. Franchi, M. Manzoni, J. Rademacher, S. Brugnatelli, P. Quaretti, M. Maestri, P. Dionigi
Journal: Journal of Hepatology (2011)
Metabolic Responses to Acute and Chronic<scp>l</scp>-Dopa Administration in Patients with Parkinsonism
Authors: Cesare R. Sirtori, Per Bolme, Daniel L. Azarnoff
Journal: New England Journal of Medicine (1972)

Abstract The metabolic effects of L-dopa were studied in 23 patients with Parkinsonism. Levels of plasma growth hormone were elevated two hours after administration of 0.5 to 1.0 g of L-dopa, and this response persisted for at least one year. Plasma glucose was increased at two hours, and free fatty acids at four hours. Chronic therapy significantly increased serum cholesterol (approximately 10 per cent), but no change in serum triglycerides, thyroxine, fasting blood sugar, and 24-hour urinary excretion of 17-keto and 17-ketogenic steroids was observed. After one year of chronic L-dopa therapy, there was a decrease in glucose tolerance associated with a delayed and exaggerated insulin response. The changes in growth hormone and carbohydrate tolerance suggest that patients receiving L-dopa for long periods should be monitored for the possible development of frank acromegaly.
Anorectal Ulcer in Chicken-pox
Authors: S. T. Winter
Journal: BMJ (1955)

Comparing the foot to a half-dome has these three advantages over the older description: (1) It gives a true picture of how the weight is transmitted through the foot.(2) It forbids false impressions of how the foot is used in walking.(3) It allows of a better under- standing of the deformities seen in flat-foot.
Solitary Lesion of Femur
Authors: Robert F. Rider
Journal: JAMA (1970)

Dr. Richard M. Heller: This is the first admission to Massachusetts General Hospital for a 20-year-old white man who complained of pain in the left hip for six months. The findings of physical examination were normal, and results of the laboratory tests were completely normal. Roentgenograms of the hip were done at the time of admission. (Fig 1). <h3>Discussion</h3> Dr. Laurence L. Robbins: Dr. Otto, would you comment on this case, please. Dr. William J. Otto: There is a solitary lesion in the left proximal femur involving the greater trochanter and intertrochanteric area extending into the femoral neck. The cortex appears intact, and there is no soft-tissue mass visible. There are a few sclerotic lines crossing the lesion which seem to be true septa rather than scalloping of the inner cortex. The margins of the lesion are not very sharp. There is no sclerosis in the surrounding bone and no
Hormone-replacement therapy and the risk of breast cancer
Authors: B. S. Hulka
Journal: CA A Cancer Journal for Clinicians (1990)

At least 30 epidemiologic studies designed to identify an associationbetween hormone-replacement therapy and breast cancer risk have beenpublished since 1974. In general, the design, quality, and analyticstrategies used in these studies have improved over the years, and thenumber of subjects in each study has increased. The results from studiespublished prior to 1985 can be summarized as showing a small increase inthe risk of breast cancer after many years of estrogen use. Even thistentative conclusion is debatable, however, since many rigorous studiesshowed no association between estrogen use and breast cancer. This reviewwill summarize the earlier findings and emphasize several large, recentstudies that add at least two new dimensions to this body of research; theyprovide data from Europe and on the addition of progestins to thetherapeutic regimen. This review indicates the following: 1. Analyses ofever versus never use of estrogen-replacement therapy show no associationwith breast cancer risk. 2. Duration of estrogen-replacement therapyaffects risk. Based on studies in the United States, a relative risk ofabout 1.5 may be reached after 15 or more years of use. 3. The increase inrisk after long-duration hormone use is present for women with either anatural or a surgical menopause. 4. European studies exhibit higher risksafter shorter durations of hormone use than do US studies. 5. The type ofestrogen used and the addition of progestins to hormone-replacement therapymay alter the risk of breast cancer. Data that substantiate these pointsare reviewed and placed in context with hormonal theories ofcarcinogenesis.
CLAY MODELING IN THE STUDY OF ANATOMY.
Authors: ARTHUR P. HERRING
Journal: JAMA (1904)

"It would be difficult to overrate the value of anatomic knowledge to every class of medical men, physicians as well as surgeons; and every one knows that this knowledge can never be acquired to any desirable degree of accuracy except by those who labor for it with the scalpel in their hands." This remark, made by Dr. Samuel Chew in 1864, is especially applicable to the student of the present day. Not alone is the scalpel necessary in order to comprehend the structure of the human body, but the microscope, modeling, drawing, the study of serial sections, and other accessories must be utilized to make clear what to most students is a difficult and ofttimes an uninteresting subject, Only one of the many helps in the study of anatomy will be presented in this paper, namely, the use of clay modeling in the study of anatomy. The modeling of
Reduction of FK-506 requirements by combination with polyethylene glycol superoxide dismutase in orthotopic rat liver transplantation
Authors: P N Rao, X Cai, R Venkataramanan, J L Platt, A Demetris, A Thunberg, C Faltynek, T Starzl, P Kumar
Journal: Journal of Allergy and Clinical Immunology (1995)
819 IMPROVEMENT OF SURVIVAL IN A SWINE MODEL OF ACUTE LIVER FAILURE BY A NEW LIVER SUPPORT SYSTEM (HEPA WASH®)
Authors: A. Al-Chalabi, E. Matevossian, A.-K. Preissel, Z. Yang, C. Schreiber, P. Schimmel, E. Nairz, H. Yan, A. Geiger, B. Kreymann
Journal: Journal of Hepatology (2010)