tbuckley/cabot-search huggingface dataset:
IMPELLA IMPROVES CLINICAL OUTCOMES WHEN EXTENSIVE REVASCULARIZATION IS PERFORMED: THE PROTECT II STUDY
Authors: Jeffrey J. Popma, Jeffrey Moses, Neal Kleiman, Alexandra Almonacid, David Burke, Simon Dixon, Brijeshwar Maini, Suresh Mulukutla, Jos&eacute; Henriques, Vladimir Dzavik, Erik Ohman, William O&apos;Neill
Journal: Journal of the American College of Cardiology (2012)
The Pocket Guide to Grant Applications
Authors: N. Black
Journal: BMJ (1998)

I K Crombie, C du V Florey

BMJ Publishing Group, £16.95, pp 88

ISBN 0 7279 1219 4

Doctors have traditionally received little or no formal help in learning some of the most useful and important skills that they need, such as dealing with bereavement, organising their work, management and team skills, and even some practical clinical activities. The ability to carry out research could also be included. This tradition may be peculiar to the British, with their reverence for the enthusiastic amateur, but it risks making either for poor quality research or for many …
ANALYTICAL PATHOLOGY
Authors: Louis G. Ortega, Robert C. Mellors
Journal: The Journal of Experimental Medicine (1956)

The principal objective of this investigation was to define the roles of injected and autogenous, kidney-localizing antibodies in the pathogenesis of rat nephrotoxic nephritis by relating data obtained with fluorescent antibody techniques to clinical and histologic observations. Such an analysis of the nephritis that developed in 28 rats after injection with the crude gamma-globulin fraction of nephrotoxic serum has led us to the following conclusions:- The renal localization of nephrotoxic antibodies is primarily and, perhaps, exclusively in the membranes of the glomerular tufts. These antibodies are demonstrable, as antigens, in the glomeruli for up to 3 months after injection. In the acute stage of the nephritis, non-antibody, autogenous globulins are present in the glomerular tufts, probably as components of edema fluid. From 6 and 9 days to 3 months after injection, autogenous antibodies are localized in the glomerular tufts in a pattern that corresponds closely to that of the nephrotoxins. The essential requirements for the operation of the mechanism postulated by Kay are fulfilled in rat nephrotoxic nephritis.
Preserved bioactivity and tunable release of a SDF1-GPVI bi-specific protein using photo-crosslinked PEGda hydrogels
Authors: Marianne K. Schesny, Michael Monaghan, Andrea H. Bindermann, Désirée Freund, Martina Seifert, Johannes A. Eble, Sebastian Vogel, Meinrad P. Gawaz, Svenja Hinderer, Katja Schenke-Layland
Journal: Biomaterials (2014)

Chemokine-induced stem cell recruitment is a promising strategy for post myocardial infarction treatment. Injection of stromal cell-derived factor 1 (SDF1) has been shown to attract bone marrow-derived progenitor cells (BMPCs) from the blood that have the potential to differentiate into cardiovascular cells, which support angiogenesis, enabling the improvement of myocardial function. SDF1-GPVI bi-specific protein contains a glycoprotein VI (GPVI)-domain that serves as an anchor for collagen type I (Col I) and III, which are exposed in the wall of injured vasculature. In this study, we generated a cytocompatible hydrogel via photo-crosslinking of poly(ethylene glycol) diacrylate that serves as a reservoir for SDF1-GPVI. Controlled and sustained release of SDF1-GPVI was demonstrated over a period of 7 days. Release features were modifiable depending on the degree of the crosslinking density. Functionality of the GPVI-domain was investigated using a GPVI-binding ELISA to Col I. Activity of the SDF1-domain was tested for its CXCR4 binding potential. Preserved functionality of SDF1-GPVI bi-specific protein after photo-crosslinking and controllable release was successfully demonstrated in vitro supporting the implementation of this drug delivery system as a powerful tool for therapeutic protein delivery in the treatment of cardiovascular ischemic disease.
Assessment of QT interval prolongation and autonomic nervous dysfunction in patients undergoing orthotopic liver transplantation
Authors: R MOHAMMED
Journal: Hepatology (1995)

The acu-men;™: A new device for continuous renal replacement therapy in acute renal failure.We sought to design a simple machine to safely provide continuous veno-venous hemofiltration to acute renal failure patients.The acu-men™ device uses a pneumatic blood pump with tidal blood flow as the driving force. A volumetric balancing system balances the filtrate with the replacement fluid, and the blood—air interface is eliminated by replacing the conventional venous drip chamber with two air-separating membranes. The extracorporeal circuit is integrated in a disposable cartridge, which is inserted into the machine at the beginning of treatment. The priming and rinsing is done automatically.While preliminary data from an ongoing clinical trial on the efficacy of this device are encouraging, further longer-term studies are necessary to evaluate its potential to decrease morbidity and mortality in acute renal failure patients.
Do We Really Need More New Medical Schools?
Authors: Richard H. Moy
Journal: JAMA (1971)

If the question were, "Do we need to expand opportunities for medical education?" there would be very little controversy. Thus, the real question is whether the need to expand opportunities is best served by the expansion of existing medical schools or by the creation of new schools. I have no categorical answer to this question, since it must be decided ultimately on the basis of local opportunities and resources. There are a number of cogent points that can be made in favor of considering the establishment of new centers of medical education, and I think that these should be considered by states, communities, and educational institutions as they look to their long-term needs. It is unfortunate that the shortage of funds at this time has made this a competitive question, since in more tranquil times the new medical schools may well be, and perhaps of necessity will be, complementary to
A158: CpG‐Induced Macrophage Activation Syndrome Develops Through an Organism Level Resistance to Toll‐like Receptor 9 Tolerance
Authors: Lehn K. Weaver, Edward M. Behrens
Journal: Arthritis & Rheumatology (2014)

Background/Purpose: Macrophage activation syndrome (MAS) is a cytokine storm syndrome known to complicate severe inflammatory diseases, and can be seen in patients with systemic rheumatologic conditions. Recent data implicates repeated adjuvant stimulation using the CpG Toll‐like Receptor 9 (TLR9) agonist as a model of the feed forward inflammatory cycle seen in cytokine storm syndromes. These results contradict the well known phenomenon of TLR tolerance, whereby repeated doses of TLR agonists result in diminishing inflammatory responses to additional stimuli. In contrast, CpG‐induced MAS results in a dose‐dependent increase in systemic inflammation in a process dependent on TLR9, Interferon‐γ (IFNγ), and Interleukin (IL)‐12. Methods: C57BL/6 and Yet40 IL‐12 reporter mice were treated with 0–4 doses of CpG before harvesting tissues to measure parameters of MAS. Analysis of ex vivo and in vitro cellular TLR9 tolerance was performed on whole splenocytes, bone marrow‐derived dendritic cells (BMDC) and bone marrow‐derived macrophages (BMMP). IL‐12 production was measured from supernatants by ELISA and intracellular IL‐12 was assessed by flow cytometry. Results: Our data recapitulate the well described phenomenon of TLR9 tolerance whereby repeated stimulation with CpG leads to reduced cytokine production using in vitro cultures of whole splenocytes, BMDC and BMMP. Interestingly, IFNγ does not alter the responsiveness of cells to a TLR9 tolerizing stimulus, as the addition of exogenous IFNγ does not rescue TLR9 tolerance in vitro . In contrast, repeated injections of CpG in whole animals results in a dose‐dependent increase in cytokine production, cellular tissue infiltration, cellular responsiveness to CpG, and immunopathology. This dose responsive systemic inflammation correlates with the continued responsiveness of splenic, liver, and bone marrow leukocytes to CpG after in vivo systemic CpG stimuli. Conclusion: Despite demonstrating TLR9 tolerance in multiple cell types in vitro , we show that cells remain responsive to CpG stimulation ex vivo even in mice previously treated with systemic CpG. Without the negative regulatory mechanisms of TLR tolerance, repeated injections of CpG lead to a feed forward systemic inflammatory response resulting in systemic immunopathology. These observations elucidate a novel mechanism whereby persistent adjuvant is sufficient to drive the uncontrolled inflammatory responses seen in MAS because of in vivo failure of TLR9 tolerance.
The Effect of Topically Applied Beclomethasone
Authors: E. J. Raffle., W. Frain-Bell
Journal: British Journal of Dermatology (1968)

Journal Article The Effect of Topically Applied Beclomethasone Get access E. J. Raffle., E. J. Raffle. Department of Dermatology, University of Dundee Search for other works by this author on: Oxford Academic Google Scholar W. Frain‐Bell W. Frain‐Bell Department of Dermatology, University of Dundee Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 80, Issue 2, 1 February 1968, Page 124, https://doi.org/10.1111/j.1365-2133.1968.tb12275.x Published: 01 February 1968
Changes in the cytokeratin intermediate filament cytoskeleton associated with mallory body formation in mouse and human liver
Authors: Y. Katsuma, S. H. H. Swierenga, U. Khettry, N. Marceau, S. W. French
Journal: Hepatology (1987)

Mouse and human extracted liver tissue were examined by indirect immunofluorescent staining and transmission electron microscopy in order to study the alteration of cytokeratin intermediate filaments associated with Mallory body formation. Frozen sections of griseofulvin-fed mouse liver and human liver of primary biliary cirrhosis and primary sclerosing cholangitis were extracted by Triton X-100 and nuclease. Indirect immunofluorescent staining was performed by using anticow hoof keratin antibody for mouse liver and anti-human epidermal keratin antibody (AE1 and AE3) for human liver. Transmission electron microscopy was also performed on extracted and critical point-dried samples. The griseofulvin-fed mouse hepatoma cells showed four different types of altered staining pattern based on the indirect immunofluorescent staining of the cytoplasm and Mallory bodies: Type I--cytoplasm(+), Mallory body(-); Type II--cytoplasm(+), Mallory body(+); Type III--cytoplasm(-), Mallory body(+), and Type IV--cytoplasm(-), Mallory body(-). Types I and III were predominant, however, some hepatoma cells which contain Mallory bodies revealed bright cytoplasmic staining (Type II). The nuclear rims were strongly stained. In human liver, AE1 stained Mallory bodies and the bile duct epithelium intensely, but did not stain normal hepatocytes. AE3 mainly stained Mallory bodies and normal hepatocytes, but also stained bile duct epithelium weakly. Indirect immunofluorescent staining for human liver showed the same staining patterns as found in mouse liver, except that Type IV was not observed. Although many hepatocytes which contained Mallory bodies did not react with either of these two antibodies (Type III), some of the hepatocytes were stained, not only with AE3, but also with AE1 (Type II).(ABSTRACT TRUNCATED AT 250 WORDS)
Functional Dysconnectivity of Corticostriatal Circuitry as a Risk Phenotype for Psychosis
Authors: Alex Fornito, Ben J. Harrison, Emmeline Goodby, Anna Dean, Cinly Ooi, Pradeep J. Nathan, Belinda R. Lennox, Peter B. Jones, John Suckling, Edward T. Bullmore
Journal: JAMA Psychiatry (2013)

Dysregulation of corticostriatal circuitry has long been thought to be critical in the etiology of psychotic disorders, although the differential roles played by dorsal and ventral systems in mediating risk for psychosis have been contentious.To use resting-state functional magnetic resonance imaging to characterize disease-related, risk-related, and symptom-related changes of corticostriatal functional circuitry in patients with first-episode psychosis and their unaffected first-degree relatives.This case-control cross-sectional study was conducted at a specialist early psychosis clinic, GlaxoSmithKline Clinical Unit, and magnetic resonance imaging facility. Nineteen patients with first-episode psychosis, 25 of their unaffected first-degree relatives, and 26 healthy control subjects were included in this study.Voxelwise statistical parametric maps testing differences in the strength of functional connectivity between 6 striatal seed regions of interest (3 caudate and 3 putamen) per hemisphere and all other brain regions.Disease-related changes, reflecting differences between patients and control subjects, involved widespread dysregulation of corticostriatal systems characterized most prominently by a dorsal-to-ventral gradient of hypoconnectivity to hyperconnectivity between striatal and prefrontal regions. A similar gradient was evident in comparisons between relatives and control subjects, identifying it as a genetically inherited risk phenotype. In patients, functional connectivity in risk-affected and disease-affected dorsal frontostriatal circuitry correlated with the severity of both positive and negative symptoms.First-episode psychosis is associated with pronounced dysregulation of corticostriatal systems, characterized most prominently by hypoconnectivity of dorsal and hyperconnectivity of ventral frontostriatal circuits. These changes correlate with symptom severity and are also apparent in unaffected first-degree relatives, suggesting that they represent a putative risk phenotype for psychotic illness.
Pharyngoconjunctival Fever Due to Type 1 Adenovirus
Authors: Richard K. Merchant, Wallace P. Rowe, Julius A. Kasel, John P. Utz
Journal: New England Journal of Medicine (1958)

PHARYNGOCONJUNCTIVAL fever is a recently recognized pathologic entity characterized by fever, conjunctivitis, pharyngitis, malaise and cervical lymphadenopathy.1 , 2 Although the majority of outbreaks of this disease have been caused by Type 3 or Type 7 adenovirus,3 4 5 6 7 8 occasional sporadic cases have been observed in association with infection with adenovirus Types 1, 2, 5 and 6.9 An outbreak in Finland, thought initially to be due to Type 4 adenovirus,10 now appears to have been caused by Type 7.11 Two cases of typical pharyngoconjunctival fever due to Type 1 adenovirus have been reported previously by Fukumi12 and by Evans.13 Jordan et al.14 have also . . .
Smallpox Vaccinations and Adverse Events
Authors: Hillel W. Cohen, Robert M. Gould, Victor W. Sidel
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Predictors of adverse cardiac events following beta brachytherapy for in-stent restenosis
Authors: Philip Urban, Patrick Serruys, Dietrich Baumgart, Antonio Colombo, Sigmund Silber, Eric Eeckhout, Hans Heuer, Karl Heinz Kuck, Thomas Schiele, Karl Weigscheider, Raoul Bonan
Journal: Journal of the American College of Cardiology (2002)
Fight against fraud tracks 'miracle cures'
Authors: Kathryn Simmons
Journal: JAMA (1985)

For every physician unable to cure the incurable, there are countless charlatans who claim they can. With asparagus oil, coffee enemas, and ground diamond dust, they claim to "cure" cancer. For arthritis, there are extracts of the green-lipped mussel, cow manure poultices, and radon gas treatments from uranium mines. And for the aging, there are innumerable devices and gadgets touted to eliminate wrinkles, restore hair, and cure senility. It's all part of what a 1984 Congressional report called a "$10 billion a year scandal." The federal government now is enlisting state, local, and private agencies to combat it. The FDA is one of several federal agencies charged with policing health fraud; its role is to enforce the Food, Drug, and Cosmetics Act of 1938. With sanctions ranging from regulatory (or warning) letters to seizures, injunctions, and civil and even criminal proceedings, the FDA has perhaps the broadest authority of all
Is the variability of nickel patch test reactivity over time associated with fluctuations in the systemic T-cell reactivity to nickel?
Authors: K. Masjedi, M. Bruze, M. Hindsén, J. Minang, N. Ahlborg
Journal: British Journal of Dermatology (2009)

Patch test reactivity to nickel varies over time. To what extent this variation is associated with fluctuations in the T-cell reactivity to nickel is not known.Our aim was to investigate the relationship between variation over time in the patch test and the systemic T-cell reactivity to nickel.Patients (n = 15) with a history of contact allergy to nickel were subjected to three consecutive patch tests at 3-month intervals, utilizing NiSO4 at 10 concentrations ranging from 0.0032% to 12.5%. Prior to each patch test, blood mononuclear cells were analysed for T-cell reactivity to nickel by interleukin (IL)-4 and IL-13 enzyme-linked immunospot assay.Eleven patients reacted positively in all three patch tests, two patients reacted in one or two tests and two remained negative. All 13 positive patients displayed variability over time, in terms of the lowest dose of nickel to which they responded. Also the cytokine response to nickel varied over time but the patients' mean cytokine response was positively correlated with their mean patch test reactivity (r(s) = 0.70, P < 0.01 for IL-4; r(s) = 0.78, P < 0.001 for IL-13). However, although the changes over time in patch test reactivity and the cytokine responses to nickel displayed a similar pattern in many patients, there was no significant correlation between the individuals' variation over time in vivo and in vitro.The overall magnitude of the T-cell reactivity to nickel and the patch test reactivity are closely associated but fluctuations in the systemic T-cell reactivity cannot be singled out as the major cause of longitudinal variability in nickel patch test reactivity.
Full-Term Abdominal Pregnancy
Authors: Daniel B. Dormán
Journal: New England Journal of Medicine (1951)

ALTHOUGH ectopic pregnancy is reported as occurring once in 100 pregnancies, only 1 per cent of extrauterine pregnancies reach the stage of viability, — an incidence of approximately 1:10,000. The incidence of abdominal pregnancy is 16 times higher in Negresses than among white women, is higher in women over the age of 30 and is more often seen in a first or second pregnancy. In 1935 Hellman and Simon1 calculated that 316 authentic instances of abdominal pregnancy had been reported up to that time. Mitra2 of India has stated that he had found 420 cases up to 1938 in the . . .
Pneumocystis carinii pneumonia complicating low dose methotrexate treatment for psoriatic arthropathy.
Authors: P J Wallis, K S Ryatt, T J Constable
Journal: Annals of the Rheumatic Diseases (1989)

A case of Pneumocystis carinii pneumonia complicating low dose methotrexate treatment for psoriasis and psoriatic arthropathy is described. This potentially fatal event was probably precipitated by an interaction between methotrexate and concurrent non-steroidal anti-inflammatory drugs, resulting in serious potentiation of the effects of methotrexate.
Health will be key responsibility of new Scottish parliament
Authors: Bryan Christie
Journal: BMJ (1997)

Control of the health service in Scotland is to pass to a Scottish parliament after the decisive vote in favour of devolution. It marks the biggest constitutional change in the United Kingdom since the partition of Ireland 76 years ago and gives Scotland its own parliament for the first time in almost 300 years.

Health will be one of the main responsibilities of the Scottish legislature, but there are mixed views about the likely impact of the change in a country that has some of the worst health problems in the Western world. Some doctors believe that returning control to a more local level provides an unprecedented opportunity to …
(24) Lichen myxoedematosus
Authors: J.P.H. Byrne, R.H. Marten
Journal: British Journal of Dermatology (2006)

Journal Article (24) Lichen myxoedematosus Get access J.P.H. Byrne, J.P.H. Byrne King's College Hospital Search for other works by this author on: Oxford Academic Google Scholar R.H. Marten R.H. Marten King's College Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 95, Issue s14, 1 December 1976, Pages 52–54, https://doi.org/10.1111/j.1365-2133.1976.tb07912.x Published: 01 December 1976
STUDIES ON THE EFFECT OF TRITON (WR-1339) ON GUINEA PIG TISSUES
Authors: Robert A. Patnode, Paul C. Hudgins
Journal: The Journal of Experimental Medicine (1958)

The administration of triton WR-1339 (300 mg./kg. subcutaneously) to tuberculin-sensitive guinea pigs 2 hours before the intradermal injection of PPD depresses slightly their skin sensitivity to tuberculin and essentially obliterates the lytic effect of tuberculin on their circulating leucocytes. When leucocytes from tuberculin-sensitive guinea pigs are exposed to triton in vitro at a concentration level attainable in vivo the cells are partially protected against lysis by PPD.
AUTORADIOGRAPHIC ANALYSIS OF LYMPHOPOIESIS AND LYMPHOCYTE MIGRATION IN MICE BEARING MULTIPLE THYMUS GRAFTS
Authors: M. Matsuyama, Margaret N. Wiadrowski, D. Metcalf
Journal: The Journal of Experimental Medicine (1966)

Lymphopoiesis was studied in 3-month-old normal C57Bl mice and in 3-month-old C57Bl mice carrying from 12 to 48 C57Bl thymus grafts using tritiated thymidine labeling. Thymus graft lymphopoiesis was found to be identical with that of normal thymus tissue and the presence of thymus grafts was found to have no influence on host thymus lymphopoiesis. No evidence was found that the massive amounts of thymus graft tissue in the mice affected any parameter of host lymph node lymphopoiesis nor was any evidence detected for the migration of thymic lymphocytes from these massive deposits of thymus graft tissue either to host lymph nodes and blood or to other organs in the host animal. It is concluded that the majority of small lymphocytes produced in the thymus and thymus graft tissue do not migrate from these tissues but die locally at the end of their intrathymic life span of 3 to 4 days.
Prevalence and prognostic value of hepatocellular carcinoma in cirrhotic patients presenting with spontaneous bacterial peritonitis
Authors: Josep M Llovet, Eduardo Moitinho, Margarita Sala, Ramón Bataller, Pilar Rodríguez-Iglesias, Antoni Castells, Javier Fernández, Ramon Planas, Miquel Navasa, Jordi Bruix, Juan Rodés
Journal: Journal of Hepatology (2000)