tbuckley/cabot-search huggingface dataset:
Abstract PR5: The receptor tyrosine kinase layer of breast cancer cell lines is predictive of the response to therapeutic drugs
Authors: Mario Niepel, Marc Hafner, Emily Pace, Birgit Schoeberl, Peter K. Sorger
Journal: Cancer Research (2012)

Abstract Currently, clinicians use the levels of the hormone receptors for estrogen (ER) and progesterone (PR) and amplifications of the ErbB2 receptor tyrosine kinase (RTK) to distinguish three groups of breast cancers and guide the choice of therapeutic treatments. In this work we show that a limited number of measurements characterizing breast cancer cell lines at the level of RTKs can be used to predict cell line sensitivity to therapeutic inhibitors. We chose a panel of approximately 40 breast cancer cell lines, treated them with 22 different growth factors and cytokines at a saturating and subsaturating dose for 10, 30, and 90 min and measured the phosphorylation of key kinases downstream of the receptors. In addition, we measured the expression and phosphorylation levels of approximately 20 RTKs under serum starvation conditions. We used the measurements to predict the GI50 values of the cell lines in response to over 70 therapeutic inhibitors by partial least square regression. We found that our measurements are sufficient to predict the response to about half of the drugs studied. The majority of drugs we are able to predict target RTKs directly or kinases immediately downstream of the receptors. In some cases we are able to predict the response to drugs that target processes seemingly unrelated to our measurements. We are currently exploring the data to uncover what drives sensitivity and resistance to drugs, gain mechanistic insight in the action of cancer therapeutics, and find predictors of drug response that may be useful in a clinical setting. Our results suggest that a carefully selected set of measurements might be sufficient to classify responsiveness of breast cancers to a number of cancer drugs currently used in the clinic. This is particularly relevant in the case of cancers like triple-negative breast cancers for which choosing effective treatment has proven difficult. This proffered talk is also presented as Poster A17.This proffered talk is also presented as Poster A17. Citation Format: Mario Niepel, Marc Hafner, Emily Pace, Birgit Schoeberl, Peter K. Sorger. The receptor tyrosine kinase layer of breast cancer cell lines is predictive of the response to therapeutic drugs [abstract]. In: Proceedings of the AACR Special Conference on Chemical Systems Biology: Assembling and Interrogating Computational Models of the Cancer Cell by Chemical Perturbations; 2012 Jun 27-30; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2012;72(13 Suppl):Abstract nr PR5.
Lymphangiography in Patients with Pulmonary Dysfunction.
Authors: Charles S. La Monte
Journal: Annals of Internal Medicine (1969)

s1 May 1969Lymphangiography in Patients with Pulmonary Dysfunction.Charles S. La Monte, M.D., Mortimer J. Lacher, M.D., F.A.C.P.Charles S. La Monte, M.D.Search for more papers by this author, Mortimer J. Lacher, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1098_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince reports of deterioration of pulmonary function in normal patients after lymphangiography with 20 ml of Ethiodol®, lung disease has been considered a contraindication to the procedure. Unless this assertion is critically examined, lymphangiography may be denied to many patients with lymphoma because of the high incidence of lung disorders occurring independently or secondary to the disease or its treatment. In eight patients undergoing detailed preliminary evaluation (viral capacity, residual volume, total lung capacity, maximum voluntary ventilation, forced expiratory volume, DLCOs, arterial pH, Pco2, Po2), seven were found to have pulmonary dysfunction. Nevertheless, because of the importance for management of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1098-1098KeywordsForced expiratory volumeLungsLymphomaPartial pressure of carbon dioxidePartial pressure of oxygenPulmonary diseasesPulmonary functionRespiratory system proceduresTotal lung capacity Issue Published: 1 May 1969 PDF DownloadLoading ...
The Removable Hot Spot
Authors: ZVI H. OSTER
Journal: Clinical Nuclear Medicine (1988)

A young woman was referred for Tc-99m DTPA imaging 1 week after renal transpiantation because of anuria. The flow study and the post-flow images did not show any activity in the right groin where the transplant was placed. Minimal activity was seen in the area of the right native kidney. A gradually increasing area of tracer concentration with a photopenic center was noticed in the lower midabdomen. On questioning the patient it was found that she was menstruating. After removing a vaginal tampon, the image showed almost complete disappearance of activity, seen previously in the lower pelvis. Menstrual bleed was demonstrated by Tc-99m DTPA extravasation and accumulation in a vaginal tampon.
VISCERAL DEPRESSOR FOR USE IN CLOSLNG LAPAROTOMY WOUNDS
Authors: L. Miller Kahn
Journal: JAMA (1913)

The device illustrated is a simple cloth triangle with a hem on the two long sides to permit the introduction of the blades of a curved dressing forceps. The base of the triangle is 3½ inches and the sides 5 inches. At the apex is sewn a piece of tape, 10 inches in length. This tape is to be fastened to one of the finger-rings of the handle, so that the triangle will not slip from the blades. The purpose of the instrument is readily understood from the drawing. When an abdominal wound is ready to be closed, the instrument (forceps blades adjusted into triangle) is inserted, the points of the blades carried within the peritoneal cavity and brought against the under surface of the parietal peritoneum. The blades are now separated as widely as possible. This puts the cloth diaphragm on the stretch, and while retaining the viscera, permits
Expression of IFN-γ–inducible protein; monocyte chemotactic proteins 1, 3, and 4; and eotaxin in TH1- and TH2-mediated lung diseases
Authors: Deborah Miotto, Pota Christodoulopoulos, Ron Olivenstein, Rame Taha, Lisa Cameron, Anne Tsicopoulos, A.-B. Tonnel, O. Fahy, J.J. Lafitte, Andy D. Luster, B. Wallaert, Christina E. Mapp, Qutayba Hamid
Journal: Journal of Allergy and Clinical Immunology (2001)
Effect of pressure-controlled intermittent coronary sinus occlusion on pacing-induced myocardial ischemia in domestic swine.
Authors: F A Fedele, R J Capone, A S Most, H Gewirtz
Journal: Circulation (1988)

This study tested the hypothesis that pressure-controlled intermittent coronary sinus occlusion (PICSO) would be useful in ameliorating myocardial ischemia under conditions characterized by preserved, but reduced (relative to demand), myocardial blood flow. Studies were conducted in closed-chest, sedated domestic swine prepared with an artificial stenosis that reduced luminal diameter of the animal's left anterior descending coronary artery by 80%. Measurements of hemodynamics, regional myocardial blood flow, and oxygen, lactate, and nucleoside metabolism were obtained in 10 animals (1) before placement of stenosis, (2) 30 min after insertion of stenosis, (3) after 30 and 60 min of PICSO, and (4) 30 min after discontinuation of PICSO. Two groups of control animals were studied to observe the natural history of metabolic markers of ischemia. Control group I consisted of four animals studied concurrently and subjected to the same protocol except for the fact that PICSO was not applied. Control group II consisted of eight additional animals studied as a group. A specially designed balloon-tipped catheter positioned in the proximal portion of the animal's great cardiac vein was used to provide PICSO. Heart rate was controlled by atrial pacing (rate, 145 beats/min) through the study. After placement of the stenosis, flow in endocardial and transmural layers distal to the stenosis declined significantly (p less than .01) vs control. Application of PICSO failed to increase arterial inflow distal to the stenosis in any myocardial layer. Myocardial aerobic metabolism was adversely affected by stenosis and changed from consumption of lactate, inosine, and hypoxanthine before stenosis to production at 30 min after stenosis. Although PICSO was associated with reduced production and a return toward consumption of lactate, inosine, and hypoxanthine, a similar pattern of changes in lactate, inosine, and hypoxanthine metabolism was observed in control animals over a comparable period of time. In addition, regional myocardial oxygen extraction and consumption were not changed vs poststenosis levels by PICSO. However, in comparison with controls, PICSO did accelerate the rate of resolution of myocardial ischemia as assessed by lactate metabolism. At 30 min of PICSO (or sham) the change vs poststenosis was +33.6 +/- 25.0 mumol/min/100 g in the PICSO but only +6.7 +/- 29.7 in the control group (p = .05). We conclude, therefore, that even though PICSO did not alter the final level of myocardial ischemia under conditions modeled in this study it did accelerate its rate of resolution, an effect that may be beneficial clinically.
Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC
Authors: Alexa B. Turke, Kreshnik Zejnullahu, Yi-Long Wu, Youngchul Song, Dora Dias-Santagata, Eugene Lifshits, Luca Toschi, Andrew Rogers, Tony Mok, Lecia Sequist, Neal I. Lindeman, Carly Murphy, Sara Akhavanfard, Beow Y. Yeap, Yun Xiao, Marzia Capelletti, A. John Iafrate, Charles Lee, James G. Christensen, Jeffrey A. Engelman, Pasi A. Jänne
Journal: Cancer Cell (2010)
Lessons from Licorice
Authors: Christopher R.W. Edwards
Journal: New England Journal of Medicine (1991)

LICORICE extract from the root of Glycyrrhiza glabra is one of the sweetest substances known and has long been used in Chinese medicines. After the discovery of its value in the treatment of peptic ulcer, it was not long before its adverse effects on salt and water metabolism became apparent.1 The syndrome of mineralocorticoid excess that results from the ingestion of licorice was thought to be due to a direct effect of its major active component, glycyrrhetinic acid, on the mineralocorticoid receptors of the kidney. However, as indicated by Farese and his colleagues in this issue of the Journal, . . .
LDL Downregulates CYP51 in Porcine Vascular Endothelial Cells and in the Arterial Wall Through a Sterol Regulatory Element Binding Protein-2–Dependent Mechanism
Authors: Cristina Rodríguez, José Martínez-González, Sonia Sánchez-Gómez, Lina Badimon
Journal: Circulation Research (2001)

Abstract —Hypercholesterolemia is associated with endothelial dysfunction and atherosclerotic lesion formation. By mRNA–differential display analysis, we have identified lanosterol 14α-demethylase (CYP51) as a gene highly regulated by native LDLs (nLDLs) in endothelial cells. CYP51 is a cytochrome P-450 enzyme involved in the postsqualene phases of cholesterol biosynthesis. CYP51 mRNA levels decrease in nLDL-treated cells in a dose- and time-dependent manner (9-fold after 24 hours with 180 mg of LDL cholesterol per deciliter), an effect that is blocked by cycloheximide. In parallel, sterol regulatory element (SRE) binding protein-2 (SREBP-2) expression falls (10-fold), without alteration in SREBP-1 level. N -Acetyl-leucyl-leucyl-norleucinal, which inhibits catabolism of the active form of SREBPs, abolished the effect of high concentrations of nLDL on CYP51 expression. Gel-shift assays performed with the SRE of the cyp51 gene ( cyp51 -SRE) revealed a diminished SREBP-SRE interaction in LDL-treated cells. Moreover, nLDLs downregulate CYP51 promoter activity in transfection assays. Thus, atherogenic levels of nLDL downregulate endothelial CYP51 mRNA levels through a reduction in SRE–SREBP-2 interaction. Additionally, SREBP-2 and CYP51 mRNA levels are decreased in the arterial wall of hypercholesterolemic pigs. In summary, we have described for the first time, both in in vivo and in vitro systems, that CYP51 is expressed in the vascular wall and that it is downregulated together with SREBP-2 by high levels of nLDL. Because this transcription factor controls multiple cell lipid metabolism pathways, its regulation by nLDL could play a key role in lipid-mediated endothelial dysfunction.
COMPARISONS OF SAFETY PROFILE BETWEEN DURABLE AND BIODEGRADABLE POLYMER BASED DRUG ELUTING STENTS IN PORCINE CORONARY ARTERY MODEL
Authors: Takeshi Ijichi, Gaku Nakazawa, Toshiro Shinke, Daisuke Matsumoto, Hiromasa Otake, Sho Torii, Ayako Yoshikawa, Junya Shite, Yuji Ikari
Journal: Journal of the American College of Cardiology (2012)
Protecting Research Subject Welfare in Preventive Trials for Autosomal Dominant Alzheimer's Disease
Authors: Holly A. Taylor, Ellen Kuwana, Benjamin S. Wilfond
Journal: The American Journal of Bioethics (2015)

With advances in medical science come new challenges in protecting the welfare of human subjects. Our ability to identify individuals at risk of catastrophic illness may lead us to new understandings of subject vulnerability. How ought we identify and recruit genetically unique research subject populations from which much can be learned but direct benefits are absent? What level of understanding ought we require of these subjects and how must we assess their understanding? The case we present here along with three accompanying commentaries address these issues in the context of early phase preventive trials for Alzheimer’s disease.

Accompanying the case summary are commentaries by Mark Yarborough, PhD, University of California Davis, who discusses how highly targeted recruitment from a narrowly defined population places a “high price of admission” in terms of the burden on potential research subjects. Stanley Korenman, MD, and John M. Ringman, MD, of UCLA Medical Center, along with Stuart Finder, PhD, of Cedars-Sinai Medical Center, focus on the ways in which the eligible patient population may be vulnerable and recommend measures to best protect their welfare. Then Anne Simpson, MD, CMD, from the University of New Mexico Health Science Center Institute for Ethics, explores barriers and facilitators to potential subjects’ understanding of research.
Vascular Endothelial Dysfunction and Mortality Risk in Patients With Chronic Heart Failure
Authors: Stuart D. Katz, Katarzyna Hryniewicz, Ingrid Hriljac, Kujtim Balidemaj, Clarito Dimayuga, Alhakam Hudaihed, Aleksandr Yasskiy
Journal: Circulation (2005)

Background— Endothelial function is known to be impaired in subjects with chronic heart failure (CHF), but the association between endothelial function and subsequent mortality risk in CHF has not been previously reported. Methods and Results— Biomarkers of endothelial function in the systemic arterial circulation (flow-mediated dilation [FMD] in the brachial artery) and the pulmonary circulation (exhaled nitric oxide [NO] production during submaximal exercise) were prospectively assessed in 259 subjects with New York Heart Association class II–III CHF. In subjects with FMD measurements (n=149), there were 12 deaths and 5 urgent transplantations over a median follow-up period of 841 days. In subjects with exhaled NO production measurements (n=110), there were 18 deaths and 1 urgent transplantation over a median follow-up period of 396 days. Both decreased FMD and decreased exhaled NO production were associated with increased risk of death or urgent transplantation after adjustment for other known CHF prognostic factors (age, etiology of CHF, functional class, left ventricular ejection fraction) in Cox multivariate proportional-hazards models (adjusted hazard ratio [HR] estimate for a 1% decrease in FMD=1.20; 95% confidence interval [CI], 1.03 to 1.45; P =0.027; adjusted HR estimate for a 1-ppb/min decrease in exhaled NO production=1.31, 95% CI, 1.01 to 1.69, P =0.04). Conclusions— Endothelial dysfunction in CHF, as assessed by FMD in the brachial artery and exhaled NO production during submaximal exercise, is associated with an increased mortality risk in subjects with both ischemic and nonischemic CHF.
ROLE OF COMPLETENESS OF REVASCULARIZATION IN INTERMEDIATE AND LATE SURVIVAL AFTER MULTIVESSEL CORONARY ARTERY BYPASS GRAFTING SURGERY
Authors: Maroun B. Yammine, Abdul-Karim M. El-Hage-Sleiman, Thomas Schwann, Milo Engoren, Robert H. Habib
Journal: Journal of the American College of Cardiology (2014)
Multimodality Imaging of Malignant Pheochromocytoma
Authors: Nazanene H. Esfandiari, Barry L. Shulkin, Chuong Bui, Craig A. Jaffe
Journal: Clinical Nuclear Medicine (2006)

Pheochromocytomas offer the opportunity to explore multiple pathophysiological mechanisms through functional imaging. MIBG scintigraphy and PET scanning with tracers of the sympathetic nervous system are based on uptake of catecholamines and catecholamine-like compounds by hNET, the human norepinephrine transporter. In-111 pentetreotide scanning involves the imaging of somatostatin receptors on the cellular surface of tissues. FDG PET scanning examines the transport and incorporation of FDG into cells. We present a patient with malignant pheochromocytoma who underwent multitracer imaging to characterize the tumor and probe its pathophysiology to direct a therapeutic approach. This case underscores the inherent difficulties in the diagnosis and localization of malignant pheochromocytomas. Multiple approaches to functional and anatomic imaging may be required to fully delineate the extent of disease and similarly to direct radionuclide-based therapy.
Boxing, Personal Freedom and the Right of Lions to Christians
Authors: Robert E. Piston
Journal: JAMA (1986)

<h3>To the Editor.—</h3> I read with dismay the COMMENTARY by Dr Patterson<sup>1</sup>in the May 9 issue ofTHE JOURNAL. He was opposed to a ban on boxing because such a ban would interfere with personal freedoms. Dr Patterson is obviously confused about the concept of personal freedom. His argument is that the state has the right and obligation to pass laws to protect itself, and to protect its citizens, but should on no account pass laws only for the protection of the individual when that individual can make choices about what protection he himself desires. Dr Patterson cites several examples of personal freedoms that he feels are similar to the freedom to participate in boxing, and he feels that any individual who wishes to expose himself to the risks associated with boxing should be allowed to do so. There is, however, a basic difference between choices that lead
Positive iodine-131 6β-Iodomethyl-19-Norcholesterol (NP-59) Adrenal Images can Precede Return of Adrenocortical Function After O,P' DDD Treatment
Authors: MARIO SPARAGANA, LEO ACKERMAN
Journal: Clinical Nuclear Medicine (1988)

A patient with bilateral adrenal hyperplasia, due to the ectopic adrenocorticotrophic hormone (ACTH) syndrome, received a 3-month course of treatment with 1,1 dichloro-2(o-chlorophenyl)-2-(p-chlorophenyl)ethane (o,p‘ DDD), which caused adrenal hypofunction requiring steroid therapy. Eleven months later, Cushing's syndrome recurred. His CT scan showed a left adrenal gland that was enlarged and a normal-sized right adrenal gland. However, the NP-59 image showed increased uptake by both glands. Venous effluent was sampled from each adrenal vein. The plasma cortisol level from the left gland was 1392 ng/ml, and that from the right gland was 667 ng/ml. The latter value was not significantly different from the values obtained at peripheral sites (517–744 ng/ml). In the course of recovery from o,p’ DDD damage, the ability of the adrenal gland to take up NP-59 may be restored before the return of its blosynthetic and secretory functions. Serial NP-59 adrenal images can anticipate the recurrence of Cushing's syndrome after adrenolytic therapy, thereby permitting early retreatment.
Endotoxin-like Reactions to Gentamicin Sulfate
Authors: Jane E. Henney
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiac resynchronization therapy and atrial overdrive pacing for the treatment of central sleep apnoea
Authors: Lars Lüthje, Bernd Renner, Roger Kessels, Dirk Vollmann, Tobias Raupach, Bart Gerritse, Selcuk Tasci, Jörg O. Schwab, Markus Zabel, Dieter Zenker, Peter Schott, Gerd Hasenfuss, Christina Unterberg‐Buchwald, Stefan Andreas
Journal: European Journal of Heart Failure (2009)
[<sup>123</sup>I]‐phenylpentadecanoic acid uptake in patients with dilated cardiomyopathy
Authors: Eckart Miche, Andrea Radzewitz, Gunawan Notohamiprodjo, Detlev Baller, Axel Kloppe, Siegfried Eckert, Ulrich Gleichmann
Journal: European Journal of Heart Failure (2002)
Phase 1 study of polyethylene glycol formulation of interferon α-2B (Schering 54031) in Philadelphia chromosome–positive chronic myelogenous leukemia
Authors: Moshe Talpaz, Susan O'Brien, Esther Rose, Samir Gupta, Jianqin Shan, Jorge Cortes, Francis J. Giles, Stefan Faderl, Hagop M. Kantarjian
Journal: Blood (2001)
ESP: A Scientific Evaluation
Authors: Gertrude R. Schmeidler
Journal: JAMA (1966)

Over the last years, extrasensory perception has been increasingly accepted by the scientific community. Its special interest to physicians probably centers around communication, since ESP implies that unspoken feelings or ideas can directly influence others. An evaluative review of ESP, with emphasis on its probable limitations and potentialities, would be welcome.  This book serves a different purpose. It is essentially a debater's clever argument for the negative; interesting and important to the ESP specialist but too slanted for an introductory survey.  The core of the book is a detailed procedural examination of three classic ESP experiments. For each, the author demonstrates how the participants could have cheated if they chose. Suggested methods of cheating seem far-fetched: they demand the collusion of three investigators of unblemished reputation, or feats of memory, or a hypothetical, invisible accomplice. The book gives no evidence for fraud in two experiments and debatable evidence in the