tbuckley/cabot-search huggingface dataset:
STUDIES ON THE MODE OF ACTION OF DIPHTHERIA TOXIN
Authors: Peter F. Bonventre, John G. Imhoff
Journal: The Journal of Experimental Medicine (1967)

Primary heart cell cultures of embryonic guinea pigs and the neonatal rat were established and incubated with purified diphtheria toxin. The rat heart cell cultures were refractory to the effects of the toxin; protein synthesis proceeded normally as measured by the incorporation of tritiated leucine into cell proteins; beating heart cells continued to contract; and the cell monolayers remained intact after exposure to the toxin for periods as long as 72 hr. These findings are compatible with the species resistance of the rat to diphtheria toxin. The guinea pig heart cell cultures were found to be extremely sensitive to the toxin. Protein synthesis was inhibited by approximately 50% after incubation with small quantities of toxin for 3 hr. Increasing the concentration of the length of exposure to the toxin did not increase this inhibition significantly. In addition, diphtheria toxin exerted a true cytopathic effect on the guinea pig heart cells. Monolayers were destroyed when incubated with the toxin for 2 to 3 days. The results show that the heart cells reflect species resistance or sensitivity to diphtheria toxin in the absence of neural or endocrine influences and suggest further that the toxin exerts a direct toxicity to muscle cells of the heart. It is not yet possible to explain in biochemical terms why the toxin seems to act specifically on cardiac tissues.
Intramural Hematoma of the Esophagus after Variceal Sclerotherapy
Authors: D. Salomez, E. Ponette, W. Van Steenbergen
Journal: Endoscopy (1991)

Two patients with cirrhosis are presented who developed retrosternal pain and dysphagia immediately after sclerotherapy of esophageal varices. Extensive submucosal bleeding of the esophageal wall was demonstrated radiologically and endoscopically. Complete resolution occurred spontaneously and did not lead to residual complications such as strictures. Intramural hematoma of the esophagus is an unusual complication after endoscopic variceal sclerotherapy.
Abstract 3533: Resistance is useless: Development of the MDR1-selective agent NSC73306
Authors: Matthew D. Hall, Misty D. Handley, Kristen Pluchino, Kyle R. Brimacombe, Michael M. Gottesman
Journal: Cancer Research (2010)

Abstract The thiosemicarbazone NSC73306 is one of several agents identified in a screen for agents that selectively kill cells expressing the multidrug resistance transporter P-glycoprotein (MDR1, ABCB1, P-gp). Prolonged exposure of P-gp expressing cells to NSC73306 down-regulates P-gp, re-sensitizing the cells to conventional chemotherapeutics. Given the exciting potential for NSC73306 as a potential therapy for previously intractable multidrug resistant cancer cells, in vitro and in vivo validation is underway. A series of NSC73306 analogs have been synthesized in order to examine the structural requirements for MDR1-selectivity of this family of compounds, and a proposed pharmacophore for MDR1-selectivity has been generated. In parallel, new MDR1-selective chemotypes are being discovered and validated through a number of strategies, including bioinformatic, high throughput screening and drug design approaches. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3533.
Abnormalities of the peripheral blood as a presenting feature of immunodeficiency
Authors: Victor S. Blanchette, Jospeh J. Hallett, J. Michael Hemphill, Jerry A. Winkelstein, William H. Zinkham
Journal: American Journal of Hematology (1978)

Abstract The predisposition of immunodeficient patients to the development of peripheral blood abnormalities is well documented. Less often recognized is the presence of immune defects in patients who initially present with “idiopathic” forms of thrombocytopenic purpura or autoimmune hemolytic anemia in the absence of symptomatology indicative of an immunodeficiency. In this report we describe two children, each of whom had intermittent and at times severe hemolysis and thrombocytopenia secondary to formation of autoantibodies. Although the initial clinical impression was the presence of an “idiopathic” form of platelet or red cell destructive phenomenon, subsequent observations demonstrated abnormalities of the immune system which affected both B and T lymphocytes. In one of the patients there was a marked deficiency of IgA with a moderate but progressive decrease in IgM and IgG. The other patient had a moderate decrease in IgA and a failure to sensitize to dinitrochlorobenzene. Both exhibited dysmorphic features, including small stature, abnormal dentition, hyperelasticity of the skin, and hyperextensibility of the joints. Neither had significant problems with bacterial, fungal, or viral infections. These observations highlight the importance of evaluating the immune system in children with “idiopathic” forms of hemolytic anemia or thrombocytopenia. Demonstration of these abnormalities can have important therapeutic implications and may also provide information regarding the etiology of the blood abnormalities.
A murine hybridoma with large cytoplasmic inclusions of kappa light chains.
Authors: D C Reason
Journal: The Journal of Experimental Medicine (1987)

A murine hybridoma cell line has been established that consistently forms large cytoplasmic inclusions. These structures bind antibody specific for mouse kappa L chain when stained in situ. SDS-PAGE analysis of isolated inclusion bodies produce a single protein band of approximately 26,000 Mr that reacts with anti-kappa antibody when transferred to nitrocellulose. No carbohydrate was detected in association with the purified protein. These data are consistent with the intracellular retention and deposition of complete kappa L chain protein.
Cytokine gene polymorphisms in acquired bone marrow failure
Authors: Vinod Gidvani, Shakti Ramkissoon, Elaine M. Sloand, Neal S. Young
Journal: American Journal of Hematology (2007)

Some acquired aplastic anemia (AA) results from immune-mediated destruction of hematopoietic stem cells. Cytokine gene polymorphisms are implicated in controlling cytokine production and increasing the susceptibility to some autoimmune diseases. We characterized the IL-6/-174, TNF-alpha/-308, IL-10/-1082, IFN-gamma/+874, TGFbeta1/-509 single nucleotide polymorphisms (SNP's) and the IL1-RA second intron variable number tandem repeat (VNTR) alleles in 73 patients with AA and compared the frequency of genotypes to established control populations. We found that some patients with acquired AA have polymorphisms which are linked to high production of proinflammatory cytokines, particularly TNF-alpha and IFN-gamma.
Neutrophil-mediated innate immune resistance to mycobacteria
Authors: Adrian R. Martineau, Sandra M. Newton, Katalin A. Wilkinson, Beate Kampmann, Bridget M. Hall, Niga Nawroly, Geoffrey E. Packe, Robert N. Davidson, Christopher J. Griffiths, Robert J. Wilkinson
Journal: Journal of Clinical Investigation (2007)

Neutrophils contain antimicrobial peptides with antituberculous activity, but their contribution to immune resistance to tuberculosis (TB) infection has not been previously investigated to our knowledge. We determined differential white cell counts in peripheral blood of 189 adults who had come into contact with patients diagnosed with active TB in London, United Kingdom, and evaluated them for evidence of TB infection and capacity to restrict mycobacterial growth in whole-blood assays. Risk of TB infection was inversely and independently associated with peripheral blood neutrophil count in contacts of patients diagnosed with pulmonary TB. The ability of whole blood to restrict growth of Mycobacterium bovis bacille Calmette Guérin and Mycobacterium tuberculosis was impaired 7.3- and 3.1-fold, respectively, by neutrophil depletion. In microbiological media, human neutrophil peptides (HNPs) 1–3 killed M. tuberculosis. The neutrophil peptides cathelicidin LL-37 and lipocalin 2 restricted growth of the organism, the latter in an iron-dependent manner. Black African participants had lower neutrophil counts and lower circulating concentrations of HNP1–3 and lipocalin 2 than south Asian and white participants. Neutrophils contribute substantially to innate resistance to TB infection, an activity associated with their antimicrobial peptides. Elucidation of the regulation of neutrophil antimicrobial peptides could facilitate prevention and treatment of TB.
First steps are taken towards creation of a European digital library
Authors: Rory Watson
Journal: BMJ (2007)

If the current move towards the creation of digital libraries is to be successful, solutions have to be found to reconcile the principle of copyright of material with the aim of making knowledge accessible to as many people as possible.

The concept of a European digital library is still being fine tuned. But the aim is to ensure easy public online access from anywhere in the European Union, possibly through a single portal, to the increasing volume of works that individual national libraries are storing in digital form.

To help find solutions, Viviane Reding, the European commissioner for information, society, and media, …
Hemodialysis, Ammonia, and Encephalopathy
Authors: MICHAEL J. BLUMENKRANTZ
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 January 1984Hemodialysis, Ammonia, and EncephalopathyMICHAEL J. BLUMENKRANTZ, M.D., SALEH SALEHMOGHADDANMICHAEL J. BLUMENKRANTZ, M.D.Search for more papers by this author, SALEH SALEHMOGHADDANSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-1-164_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Canzanello and associates (1) report the exacerbation of encephalopathy in a patient who had hemodialysis with a recirculating dialysis sorbent system using a Sorb 31 regeneration cartridge (Organon Technicka, Oklahoma City, Oklahoma). Encephalopathy was due to ammonia release from the cartridge. The patient became agitated, confused, and unresponsive after the serum ammonia level reached 476 µg/dL. The authors concluded that a single-pass dialysis unit should be used rather than the sorbent system for patients with high blood urea nitrogen levels and hepatic dysfunction. We disagree with this recommendation.The symptoms of hyperammonemic encephalopathy have been found in...References1. CANZANELLORASMUSSENMCGOLDRICK VRM. Hyperammonemic encephalopathy during hemodialysis. Ann Intern Med. 1983;99:190-1. LinkGoogle Scholar2. ULLMANHAECKERMEDANI MTC. Hyperammonemic encephalopathy and urinary obstruction [Letter]. N Engl J Med. 1981;304:1546. CrossrefMedlineGoogle Scholar3. DRAYNATITCOMBVARMASOERGEL CCRK. Hyperammonemic encephalopathy caused by infection in a neurogenic bladder. N Engl J Med. 1981;304:766-8. CrossrefMedlineGoogle Scholar4. GENERAL INFORMATION ON THE SORBSYSTEM. Oklahoma City, Oklahoma: Organon Teknika Corporation; 1982:7. Google Scholar5. ROBERTSBLUMENKRANTZFRANCISCO MML. Custom hemodialysis with bicarbonate dialysates [Abstract]. Australian Society of Nephrology. 1984. (In press). Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: UCLA School of Medicine Los Angeles, CA 90057 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1984Volume 100, Issue 1Page: 164-164KeywordsAmmoniaBlood urea nitrogenBrain diseasesMedical dialysisRegenerative medicine Issue Published: 1 January 1984 PDF DownloadLoading ...
Randomized Double-Blind Placebo-Controlled Clinical Trial Testing Ketorolac Tromethamine for Reducing the Pain and Discomfort Experienced during Mammography.
Authors: R. Freitas-Junior, R. Freitas-Junior, L. Silveira-Junior, W. Tokaski, C. Ximenes, R. Rahal, A. Santos, M. Tomazini, E. Martins, N. Freitas
Journal: Cancer Research (2009)

Abstract OBJECTIVE: To study the possibility of reducing the pain and discomfort experienced during mammography, by means of using an analgesic as premedication. PATIENTS AND METHODS: This was a randomized double-blind placebo-controlled clinical trial testing ketorolac tromethamine for reducing the pain and discomfort experienced during mammography. There were 308 participants in the study, who all signed a free and informed consent statement. Of these, 153 patients (group 1) received 10 mg of ketorolac tromethamine orally and 155 (group 2) received placebo orally, 60 minutes before undergoing mammographic examination. After taking the medication and while waiting to undergo the procedure, the patients themselves filled out a form asking about personal data and possible factors relating to pain and discomfort while undergoing mammography. After the examination, the patients subjectively assessed the pain and discomfort experienced during the examination using a visual analog scale (VAS) graded from zero to ten. The statistical analysis consisted of characterizing the groups using absolute and relative frequencies and comparing the dependent and independent variables between the groups using the chi-squared association test, with Yates correction when necessary. RESULTS: The mean VAS pain level presented by the patients was 3.36 and the median was 2.90. It was observed that 51 (16.6%) of the patients did not present any pain, 106 (34.4%) presented mild pain, 94 (30.5%) moderate pain, 40 (13%) severe pain and 17 (5.5%) intolerable pain. With regard to discomfort, 68 (54.9%) reported tolerable discomfort, 63 (20.5%) a lot of discomfort and 8 (2.6%) intolerable discomfort. Among the factors related to pain, only the presence of previous mastalgia was significant (p &amp;lt; 0.05). Somnolence was the adverse event most present: 2.6 and 5.8% in the ketorolac and placebo groups, respectively. CONCLUSIONS: The use of 10 mg of ketorolac tromethamine did not have any influence regarding reduction of the pain and discomfort experienced by the patients during mammography, when compared with placebo. Among the factors studied, the only one associated with greater possibility of pain and discomfort while undergoing mammography was a history of mastalgia. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 4014.
Sickle Cell Trait and Other African Genetic Markers
Authors: A. P. Gelpi
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Brittenham, in his letter (225:1120, 1973) commenting on the earlier paper by Gelpi and Perrine (224:605, 1973), points out that the early work by Lehmann on the Veddoid tribes of South India showed rather conclusively that the R<sub>0</sub>(cDe) blood group marker was not present in this population despite the high frequencies of the sickle cell trait, and that subsequent studies have shown that other African Negro genetic markers are conspicuously absent in this ethnic group. This by no means invalidates the implication in our report that diffusion of the sickle cell gene may well have come from a single, African source, and for the following reasons: (1) the frequency of other African genetic markers is not likely to parallel that of the sickle cell trait in white populations unless all of these African genetic markers have in common the same selective pressures; and (2) the
Reflex and Reflection: Defining Psychotherapy in Supervision
Authors: T. Nadelson, C. Nadelson
Journal: Psychotherapy and Psychosomatics (1975)

Research Articles| February 12 2010 Reflex and Reflection: Defining Psychotherapy in Supervision Subject Area: Psychiatry and Psychology T. Nadelson; T. Nadelson Beth Hospital and Harvard Medical School, Boston, Mass. Search for other works by this author on: This Site PubMed Google Scholar C. Nadelson C. Nadelson Beth Hospital and Harvard Medical School, Boston, Mass. Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1975) 25 (1-6): 207–216. https://doi.org/10.1159/000286867 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation T. Nadelson, C. Nadelson; Reflex and Reflection: Defining Psychotherapy in Supervision. Psychother Psychosom 31 December 1975; 25 (1-6): 207–216. https://doi.org/10.1159/000286867 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1975Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Hyperkalaemia is a risk with low sodium salt in vulnerable patients
Authors: A. Dent, D. Walmsley, S. Dhandapani
Journal: BMJ (2011)

We recently admitted a man in his 80s with poor glycaemic control and osmotic symptoms. His medical history included chronic kidney disease, macrocytic anaemia, hypothyroidism, hypertension, osteoarthritis, and splenectomy. Glycaemic control was managed by twice daily insulin. On admission, creatinine concentration was 147 µmol/L, urea 8.5 mmol/L, and potassium 5.1 mmol/L while taking lisinopril. He was taking no other drugs …
Feasibility of chitosan-based hyaluronic acid hybrid biomaterial for a novel scaffold in cartilage tissue engineering
Authors: Shintaro Yamane, Norimasa Iwasaki, Tokifumi Majima, Tadanao Funakoshi, Tatsuya Masuko, Kazuo Harada, Akio Minami, Kenji Monde, Shin-ichiro Nishimura
Journal: Biomaterials (2004)
CALCAREOUS DEGENERATION OF CORNEAL CICATRICES.
Authors: H. MOULTON
Journal: JAMA (1903)

Aside from, or in, association with hyaline degeneration (colloid of Saemisch), deposits of lime salts are described as occurring in the cornea, sometimes superficially, as in the so-called "band-like opacities,"<sup>1</sup>sometimes as infiltrates of small particles,<sup>2</sup>and, again, as larger masses in the form of plates<sup>3</sup>in old cicatrices. It is the latter type to which these remarks refer. Such cases are comparatively rare and clinical reports of them are rarer still. Some text-books do not mention them at all. I have seen but two cases, both occurring within the same month. As they present some interesting clinical features, I report them: <h3>Case 1.</h3> —Mr. J. T. W., age 52, a merchant of Indian Territory, referred by Dr. Miller, came Feb. 20, 1901. He had an adherent leucoma in each eye, which he stated originated in an attack of sore eyes in 1865. Until recently the vision
The voltage-gated K+ channel subunit Kv1.1 links kidney and brain
Authors: David H. Ellison
Journal: Journal of Clinical Investigation (2009)

Analysis of Mendelian Mg2+ wasting disorders helps us to unravel the mechanisms of Mg2+ homeostasis. In this issue of the JCI, Glaudemans andcolleagues show that mutations in voltage-gated K+ channel subtype 1.1(Kv1.1) cause autosomal dominant hypomagnesemia in humans (see the related article beginning on page 936). Interestingly, other mutations in the same protein cause the neurological disease episodic ataxia type 1. The authors show, using cells with heterologous expression of the wild-type and mutant channels, that the mutant channel is dysfunctional and speculate that Mg2+ wasting results from changes in apical membrane voltage along the nephron. Mechanisms by which the apical voltage is generated and howKv1.1 fits within this context are discussed herein.
Complications and Pitfalls of Laser Therapy
Authors: E.M.H. Mathus-Vliegen
Journal: Endoscopy (1986)

228 patients have been studied in retrospect, in an attempt to delineate the limits and pitfalls of laser treatment of benign (n = 104) and malignant (n = 124) tumors. Benign colorectal adenomas (n = 78) were divided into 3 groups according to the size of the lesion. The occurrence of complications, the persistence and recurrence rate paralleled the size of the tumor. No relationship as to the number of sessions, the interval between them or the mean and/or total amount of energy was found. The prolonged time span of treatment in larger lesions was related to the formation of large ulcers and edema. Poor accessibility and difficult positioning of the laser beam interfered with adequacy of laser treatment. In familial polyposis (n = 26) laser photocoagulation appeared a highly effective, safe and easy procedure. In esophageal cancer (n = 16), gastric (n = 13) and colorectal malignancies (n = 95) laser therapy was very efficaceous in the palliation of bleeding and/or obstruction. Unfavorable anatomy and difficult accessibility were the main drawbacks. Problems in the assessment of pathology and submucosal extension impeded effective treatment of early cancer. Generally speaking, the presence of a whitish appearance, fibrosis of bloody tissue pointed toward a less favorable response, but much more has to be learned about the interaction between laser light and tissue properties.
Paraneoplastic Syndromes Involving the Nervous System
Authors: Robert B. Darnell, Jerome B. Posner
Journal: New England Journal of Medicine (2003)

Paraneoplastic neurologic syndromes are incited by a tumor outside the nervous system that produces a characteristic antigen of the nervous system. An immune response against the ectopic tumor antigen not only damages nerve tissue but also inhibits growth of the tumor.
THE FLUORESCENCE OF ERYTHRASMA.
Authors: BETTY M. PARTRIDGE, E. L. JACKSON
Journal: British Journal of Dermatology (1962)

Journal Article THE FLUORESCENCE OF ERYTHRASMA. Get access BETTY M. PARTRIDGE, BETTY M. PARTRIDGE Department of Bacteriology, King's College Hospital Medical School, London, S.E.5 Search for other works by this author on: Oxford Academic Google Scholar E. L. JACKSON E. L. JACKSON Department of Bacteriology, King's College Hospital Medical School, London, S.E.5 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 74, Issue 8-9, 1 August 1962, Pages 326–328, https://doi.org/10.1111/j.1365-2133.1962.tb13520.x Published: 01 August 1962