C-Reactive Protein and Risk for Colorectal Cancer
Authors: Luca Mascitelli, Francesca Pezzetta
Journal: Annals of Internal Medicine (2005)

Letters4 October 2005C-Reactive Protein and Risk for Colorectal CancerLuca Mascitelli, MD and Francesca Pezzetta, MDLuca Mascitelli, MDFrom Comando Brigata alpina “Julia”, 33100 Udine, Italy, and Ospedale di San Vito al Tagliamento, 33078 San Vito al Tagliamento, Italy.Search for more papers by this author and Francesca Pezzetta, MDFrom Comando Brigata alpina “Julia”, 33100 Udine, Italy, and Ospedale di San Vito al Tagliamento, 33078 San Vito al Tagliamento, Italy.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-143-7-200510040-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Zhang and colleagues (1) reported that C-reactive protein levels were not significantly associated with increased risk for colorectal cancer in women. However, they did not consider diabetic status in the studied population. A growing body of evidence indicates that type 2 diabetes mellitus is associated with increased risk for colorectal cancer (2-4). Furthermore, elevated glycated hemoglobin concentrations, even at levels below those used for diagnosis of diabetes, have been shown to be associated with increased colorectal cancer risk (5). Thus, abnormal glucose metabolism might have been a confounder in this study (1).References1. Zhang SM, Buring JE, Lee IM, Cook NR, Ridker PM. C-reactive protein levels are not associated with increased risk for colorectal cancer in women. Ann Intern Med. 2005;142:425-32. [PMID: 15767620] LinkGoogle Scholar2. Will JC, Galuska DA, Vinicor F, Calle EE. Colorectal cancer: another complication of diabetes mellitus? Am J Epidemiol. 1998;147:816-25. [PMID: 9583711] CrossrefMedlineGoogle Scholar3. Hu FB, Manson JE, Liu S, Hunter D, Colditz GA, Michels KB, et al. Prospective study of adult onset diabetes mellitus (type 2) and risk of colorectal cancer in women. J Natl Cancer Inst. 1999;91:542-7. [PMID: 10088625] CrossrefMedlineGoogle Scholar4. Kaaks R, Toniolo P, Akhmedkhanov A, Lukanova A, Biessy C, Dechaud H, et al. Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women. J Natl Cancer Inst. 2000;92:1592-600. [PMID: 11018095] CrossrefMedlineGoogle Scholar5. Khaw KT, Wareham N, Bingham S, Luben R, Welch A, Day N. Preliminary communication: glycated hemoglobin, diabetes, and incident colorectal cancer in men and women: a prospective analysis from the European prospective investigation into cancer-Norfolk study. Cancer Epidemiol Biomarkers Prev. 2004;13:915-9. [PMID: 15184246] MedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Luca Mascitelli, MD; Francesca Pezzetta, MDAffiliations: From Comando Brigata alpina “Julia”, 33100 Udine, Italy, and Ospedale di San Vito al Tagliamento, 33078 San Vito al Tagliamento, Italy.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoC-Reactive Protein Levels Are Not Associated with Increased Risk for Colorectal Cancer in Women Shumin M. Zhang , Julie E. Buring , I-Min Lee , Nancy R. Cook , and Paul M. Ridker C-Reactive Protein and Risk for Colorectal Cancer Shumin M. Zhang and Paul M Ridker Metrics 4 October 2005Volume 143, Issue 7Page: 544KeywordsAttentionC-reactive proteinsColorectal cancerConflicts of interestGlucose metabolismHemoglobinRisk managementType 2 diabetes ePublished: 4 October 2005 Issue Published: 4 October 2005 Copyright & PermissionsCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...