tbuckley/cabot-search huggingface dataset:
Microvascular Filtration Is Increased in Postural Tachycardia Syndrome
Authors: Julian M. Stewart
Journal: Circulation (2003)

Background— Postural tachycardia syndrome (POTS) is related to defective peripheral vasoconstriction of dependent extremities with redistributive hypovolemia. Methods and Results— To test whether enhanced microvascular filtration produces leg enlargement, we studied 12 patients 13 to 19 years of age with POTS and defective leg vasoconstriction and 13 age-matched healthy control subjects, with strain-gauge plethysmography used to measure venous pressure (P v ), forearm and calf blood flow, vascular capacitance, and the microvascular filtration coefficient (K f ). Measurements were made while the patient was supine and at steady state during upright tilt to 35°. Supine P v was not different in POTS, but upright leg P v tended to be increased above control. Arm and leg peripheral arterial resistance was decreased in the supine and upright positions in patients with POTS compared with control subjects ( P =0.01, upright legs). Supine K f was not significantly increased in the forearm in patients with POTS but was increased in the calf (9.3±2.2 versus 5.7±2.4 [10 −3 ] mL/100 mL per minute per mm Hg, P =0.04), correlating with calf blood flow (r s =0.84, P =0.002). K f was invariant with orthostasis. The hydraulic contribution to upright filtered flow at 35° tilt, the product of K f and P v , was approximately twice that of control (0.41±0.09 versus 0.19±0.04 mL/100 mL per minute, P =0.04). Conclusions— Increased microvascular filtration accounts for enhanced leg swelling in patients with POTS with increased arterial blood flow.
Integrated Regulation of Toll-like Receptor Responses by Notch and Interferon-γ Pathways
Authors: Xiaoyu Hu, Allen Y. Chung, Indira Wu, Julia Foldi, Janice Chen, Jong Dae Ji, Tomoko Tateya, Young Jun Kang, Jiahuai Han, Manfred Gessler, Ryoichiro Kageyama, Lionel B. Ivashkiv
Journal: Immunity (2008)
Carboxyl-terminal-dependent recruitment of nonmuscle myosin II to megakaryocyte contractile ring during polyploidization
Authors: Idinath Badirou, Jiajia Pan, Céline Legrand, Aibing Wang, Larissa Lordier, Siham Boukour, Anita Roy, William Vainchenker, Yunhua Chang
Journal: Blood (2014)
Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome)
Authors: Jakub Tolar, In-Hyun Park, Lily Xia, Chris J. Lees, Brandon Peacock, Beau Webber, Ron T. McElmurry, Cindy R. Eide, Paul J. Orchard, Michael Kyba, Mark J. Osborn, Troy C. Lund, John E. Wagner, George Q. Daley, Bruce R. Blazar
Journal: Blood (2010)
Thorax annual report: 1 October 2003 to 30 September 2004
Authors: J A Wedzicha
Journal: Thorax (2004)

The past year—and the second year of our editorship—has been a very successful one for Thorax .1,2 We have continued to receive high quality papers for publication and our impact factor for 2003 now stands at 4.188.3 This means that Thorax is now the second highest ranked of the traditional respiratory journals in terms of impact factor, behind the American Journal of Respiratory and Critical Care Medicine , and has now overtaken the American Journal of Respiratory Cell and Molecular Biology .

The journal impact factor for 2003 is calculated as the number of citations in 2003 to papers published in Thorax in 2001 and 2002. The changes in impact factor for Thorax from 1996 to 2003 and a comparison with the impact factors for the other main respiratory journals are shown in fig 1.3–5 The impact factor of a journal depends on the number of high quality papers that it publishes and this is influenced by the rigour of the peer review in the journal.6 For some time now, in addition to regular peer review in Thorax , all potentially acceptable papers have been subject to statistical review and this has had a positive effect on the quality of the papers we have published. The impact factor is also affected by the number of articles published in a journal and this makes up the denominator of the impact factor equation. Some specialist journals have reduced—often quite dramatically—the number of papers they publish. However, the number of articles (excluding editorials and letters) published in Thorax …
Japan's doctors say low fees are driving many to ruin
Authors: Jane Burgermeister
Journal: BMJ (2004)

Doctors in Japan have warned that there could be an exodus from the medical profession unless the of health and welfare ministry increases the fixed fees that doctors receive for treating patients.

The ministry—in Tokyo—sets the sums that doctors and hospitals are reimbursed for consultations, treatment, and operations by the country's social security system.

But the Japanese Medical Association says that hundreds of hospitals and general practice clinics are now facing financial ruin because they …
Systolic Hypertension in Older Persons
Authors: Sarwat I. Chaudhry, Harlan M. Krumholz, JoAnne Micale Foody
Journal: JAMA (2004)

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure emphasizes the importance of systolic hypertension (SH), defined as systolic blood pressure (SBP) of at least 140 mm Hg and diastolic blood pressure of less than 90 mm Hg, in older persons (> or =60 years).To systematically review the literature on clinical management of SH in older persons.We performed a MEDLINE search of English-language literature from 1966-2004 to identify reports about SH in older persons, with particular emphasis on data from randomized clinical trials.We selected 1064 studies by using the search terms hypertension combined with the terms systole (or systolic) and aged.There is strong evidence from clinical trials to support the treatment of SH in older persons with SBP of at least 160 mm Hg. Large-scale trials to assess the value of antihypertensive therapy for older patients with SBP of 140 to 159 mm Hg have not been performed, and recommendations to treat these patients are based on observational studies that show a graded relationship of cardiovascular risk with increasing SBP. The studies most strongly support the use of thiazide diuretics and long-acting calcium channel blockers as first-line therapy to treat SH.Treatment of SH in older patients with SBP of at least 160 mm Hg is supported by strong evidence. The evidence available to support treatment of patients to the level of 140 mm Hg or those with baseline SBP of 140 to 159 mm Hg is less strong; thus, these treatment decisions should be more sensitive to patient preferences and tolerance of therapy.
TRANSDUODENAL DECOMPRESSION AND REINTRODUCTION BY PROCTOCLYSIS OF GASTRO-INTESTINAL DRAINAGE IN ACUTE MECHANICAL ILEUS
Authors: Carl G. Roberts
Journal: JAMA (1934)

Mrs. F. B., aged 45, married and the mother of two children, admitted to St. Elizabeth Hospital, July 23, 1933, had three days previously had a sudden onset of colicky pain in the epigastrium, which localized in the right lower quadrant within twenty-four hours. Simultaneously with the onset of pain she vomited repeatedly and felt as if she had a fever. After three days of ineffectual self medication, a physician was called, who advised immediate removal to the hospital.  Her previous history was essentially negative with the exception of an attack of scarlet fever in infancy and a fracture of the right seventh rib due to an automobile accident in January 1933. The family history revealed that one sister had died of pulmonary tuberculosis.  On admission her temperature was 100 F., pulse 104 and respiration rate 28. There was marked rigidity of the right abdominal muscles with pronounced tenderness at
Assessment of Nitric Oxide Formation During Exercise
Authors: CLAUDETTE M. ST. CROIX, THOMAS J. WETTER, DAVID F. PEGELOW, KEITH C. MEYER, JEROME A. DEMPSEY
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

We measured the end-tidal plateau in exhaled NO concentration (CetNO) by chemiluminescence and calculated the product of V˙ e and CetNO (V˙ no) in nine healthy subjects at rest and during three intensities of cycling exercise (30%, 60%, and 90% V˙ o 2max), two levels of hyperventilation (V˙ e = 42.8 ± 9.1 L/min and 84.2 ± 6.6 L/min), and during breathing of hypoxic gas mixtures (five subjects, Fi O2 = 14%) at rest and during exercise at 90% V˙ o 2max. Immediately after each trial we also measured exhaled [NO] at constant expiratory flow rates ([NO]CF) of 46 ml/s and 950 ml/s, utilizing added expiratory resistance to increase mouth pressure and close the velum (Silkoff and colleagues, Am. J. Respir. Crit. Care Med. 1997;155:260). CetNO decreased and V˙ no increased above resting levels with increasing exercise intensity during hyperventilation and during hypoxic exercise (p < 0.05). [NO]CF, measured at either 46 ml/s or 950 ml/s, did not increase under any of the conditions investigated (exercise, hyperventilation, or hypoxia). Venous blood from seven of the subjects was sampled for the measurement of plasma [NO3 −]. Resting plasma [NO3 −] averaged 42.5 ± 14.7 μ mol/L, with no change during exercise, hyperventilation, or hypoxia. On the basis of these results we conclude that reported increases in V˙ no do not reflect an exercise-induced augmentation of systemic and/or airway NO production. Rather, the increases in V˙ no during exercise or hyperventilation are a function of high airflow rates, which reduce the luminal [NO]. This decreases the concentration gradient for NO between the alveolar space and pulmonary capillary blood, which results in a decrease in the fraction of NO taken up by the blood and an increase in the volume of NO recovered in the exhaled air (V˙ no). St. Croix CM, Wetter TJ, Pegelow DF, Meyer KC, Dempsey JA. Assessment of nitric oxide formation during exercise.
FURTHER STUDIES ON THE HYPOPHYSEAL SUBSTANCE GIVING INCREASED GONADOTROPIC EFFECTS WHEN COMBINED WITH PROLAN
Authors: Herbert M. Evans, Miriam E. Simpson, Paul R. Austin
Journal: The Journal of Experimental Medicine (1933)

The hypophyseal substance-the synergic factor-which gives increased gonadotropic effects when combined with prolan has been shown to itself possess a definite though slight gonadotropic activity. It produces transitory follicular enlargement within 24-48 hours, which, however, regresses at once on cessation of treatment so that by the end of the 4th day the ovary again approximates its infantile weight. The synergic principle indeed provokes only moderate ovarian development when administered in 100 times the dose necessary to demonstrate the activation phenomenon. By means of isoelectric precipitation or by means of tryptic and ereptic digestion, fractions containing the synergic principle were freed of many contaminants, in particular of the antagonistic factor. The synergic principle has been shown to be unaffected by digestion with trypsin or trypsin followed by a short digestion with erepsin, but the action of pepsin inactivated the material. A preparation of the active substance has been obtained which is potent in a total dose of 27 gamma.
Hepatocyte Transplantation Improves Phenotype and Extends Survival in a Murine Model of Intermediate Maple Syrup Urine Disease
Authors: Kristen J Skvorak, Harbhajan S Paul, Kenneth Dorko, Fabio Marongiu, Ewa Ellis, Donald Chace, Carolyn Ferguson, K Michael Gibson, Gregg E Homanics, Stephen C Strom
Journal: Molecular Therapy (2009)

Maple syrup urine disease (MSUD; OMIM 248600) is an inborn error of metabolism of the branched chain alpha-ketoacid dehydrogenase (BCKDH) complex that is treated primarily by dietary manipulation of branched-chain amino acids (BCAA). Dietary restriction is lifelong and compliance is difficult. Liver transplantation significantly improves outcomes; however, alternative therapies are needed. To test novel therapies such as hepatocyte transplantation (HTx), we previously created a murine model of intermediate MSUD (iMSUD), which closely mimics human iMSUD. LacZ-positive murine donor hepatocytes were harvested and directly injected (10(5) cells/50 microl) into liver of iMSUD mice (two injections at 1-10 days of age). Donor hepatocytes engrafted into iMSUD recipient liver, increased liver BCKDH activity, improved blood total BCAA/alanine ratio, increased body weight at weaning, and extended the lifespan of HTx-treated iMSUD mice compared to phosphate-buffered saline (PBS)-treated and untreated iMSUD mice. Based on these data demonstrating partial metabolic correction of iMSUD in a murine model, coupled to the fact that multiple transplants are possible to enhance these results, we suggest that HTx represents a promising therapeutic intervention for MSUD that warrants further investigation.
Relapsing Polychondritis Support Group
Authors: C. Ashworth
Journal: British Journal of Dermatology (1988)

Journal Article Relapsing Polychondritis Support Group Get access C. Ashworth C. Ashworth Honorary Organiser Relapsing Polychondritis Support Group 51 Croft Avenue, Altofts, Normanton, West Yorkshire WF6 2JP, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 119, Issue 3, 1 September 1988, Pages 410–411, https://doi.org/10.1111/j.1365-2133.1988.tb03241.x Published: 01 September 1988
Disclosure of Investigators' Recruitment Performance in Multicenter Clinical Trials: A Further Step for Research Transparency
Authors: Rafael Dal-Ré, David Moher, Christian Gluud, Shaun Treweek, Jacques Demotes-Mainard, Xavier Carné
Journal: PLoS Medicine (2011)

Rafael Dal-Ré and colleagues argue that the recruitment targets and performance of all site investigators in multi-centre clinical trials should be disclosed in trial registration sites before a trial starts, and when it ends.
Momentum and Morality in Medicine
Authors: SAMUEL ENOCH STUMPF
Journal: Annals of Internal Medicine (1967)

Article1 September 1967Momentum and Morality in MedicineSAMUEL ENOCH STUMPF, PH.D.SAMUEL ENOCH STUMPF, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-3-10 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn order to focus upon some of the philosophical questions provoked by the trend in modern biomedical research, I want to consider an analogy between law and medicine. In both cases, the chief concern is to track down a culprit—in law it is a criminal, and in medicine it is the cause of a disease. In both cases there is a vigorous and relentless pursuit of evidence that leads ultimately to a primary suspect. For the most part, this pursuit of information is complicated only by the difficulty of the particular case or disease. Investigation, by and large, is carried... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SAMUEL ENOCH STUMPF, PH.D.Affiliations: This study was carried out at Vanderbilt University in collaboration with the Director, Elliot V. Newman, M.D., F.A.C.P., and with the staff of the Clinical Research Center, supported by research grant HE 08195, the National Institutes of Health, Bethesda, Md., and a grant for clinical research to the Vanderbilt University School of Medicine by the G. D. Searle Foundation, Chicago, Ill. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byStudies in HumansThe Medical Scholar and His DilemmaR. H. KAMPMEIER, M.D., F.A.C.P. 1 September 1967Volume 67, Issue 3_Part_2Page: 10-14KeywordsResearch grants ePublished: 1 December 2008 Issue Published: 1 September 1967 PDF downloadLoading ...
GPs end partnerships with Virgin over conflicts of interest
Authors: Z. Kmietowicz
Journal: BMJ (2012)

More than 300 general practitioners have ended partnerships with Richard Branson’s Virgin Care to provide some hospital services in the community to avoid accusations of conflicts of interest when they take responsibility for commissioning in April 2013.

Since 2006 Virgin Care has set up 25 local provider companies together with GPs, known as GPcos. These provide NHS community services such as …
FIBRINOGEN PRECIPITATION BY STREPTOCOCCAL M PROTEIN
Authors: Fred S. Kantor
Journal: The Journal of Experimental Medicine (1965)

Intravenous injection of Type 1 streptococcal M protein into mice and rats produced lesions confined to renal glomeruli. Thrombi of eosinophilic amorphous material, seen to occlude glomerular capillaries, were shown to contain M protein and fibrinogen. Gradual regression of the morphological lesions was observed during the 3 weeks following injection. Initial abnormal proteinuria and azotemia returned to control levels by the end of the 1st week; a second rise in urinary protein excretion and urea retention was demonstrated in some rats coincident with appearance of anti-M antibodies. The mechanism of renal localization of streptococcal M protein by means of a complex with fibrinogen was suggested, which may comprise an initial phase in the pathogenesis of acute poststreptococcal glomerulonephritis.
A MICROSCOPIC STUDY OF MERCURY ABSORPTION FROM THE SKIN
Authors: KARL G. ZWICK
Journal: JAMA (1924)

DEFINITION OF THE PROBLEM  Galen's postulates of safe and rapid action are met by the method of mercurial inunctions so satisfactorily that even at the present day one or the other protagonist of the  rub, like Palmer,1champions its use to the exclusion of Ehrlich's arsenicals.  But in regard to the third galenic postulate, requiring convenience of application, mercurial ointment fails so signally that, notwithstanding their efficacy as demonstrated also by the frequency of salivation and stomatitis following their employment, inunctions, owing to their uncleanliness, their telltale character and their tendency to cause folliculitis, have been largely superseded by other modes of parenteral administration of mercury.  In prescribing the classical inunction treatment of syphilis, the patient is advised not to remove the excess of mercurial ointment remaining on the skin after prolonged friction.  To overcome the objectionable features of the inunction therapy heretofore in vogue, Cole and Sollmann
Benign breast lumps may regress with change in diet
Authors: William Check
Journal: JAMA (1979)

Many women with long-standing, clinically benign breast lumps may be able to reassure themselves that they do not have breast cancer by a much simpler means than breast biopsy, according to John Peter r Minton, MD, PhD, of the Department of Surgery at the Ohio State University College of Medicine. Minton has found that about two thirds of benign breast lumps disappear in women who completely eliminate all forms of methylxanthines—caffeine, theophylline, and theobromine—from their diets. Several years ago Minton found that cyclic nucleotides, which stimulate cell growth and division, are appreciably elevated in biopsy tissue from women with fibrocystic disease and fibroadenoma. He wondered whether the increased level of cyclic nucleotides might be contributing to the growth of the breast lumps and whether the increase might be due to methylxanthines. These chemicals are known to inhibit phosphodiesterase, the enzyme that catabolizes cyclic nucleotides. Reporting to the recent meeting of
Sunlight and Skin Cancer
Authors: Thomas B. Fitzpatrick, Arthur J. Sober
Journal: New England Journal of Medicine (1985)

In this issue of the Journal, Tucker et al.1 report an association between intraocular melanoma and exposure to sunlight. This is one more instance of the postulated link between sunlight and cancers on the exposed areas of the body — the skin and the eyes. Theoretically, the induction of skin cancer could result from continual exposures to ultraviolet radiation or possibly from occasional intensive exposures. Ultraviolet light in the range of 290 to 320 nm (ultraviolet B), weighted in accordance with its effectiveness in altering DNA, is probably the portion of ultraviolet radiation that is involved. Ultraviolet B is quite . . .
Recent Advances in the Diagnosis of Cancer
Authors: Lester S. King
Journal: JAMA (1966)

Present-day diagnostic methods involve many different disciplines, which gradually are becoming more and more esoteric. Cross-disciplinary meetings would therefore seem a logical way of disseminating knowledge. But in planning for any such meeting, the question should arise: to whom are the specialists talking? The present series of conferences are clinical—the intended audience would seem to be the clinician who has primary responsibility for determining the patient's disease and securing the appropriate treatment.  Clinicians must be intrigued by the range of diagnostic techniques presented in this volume. In the field of nuclear medicine, scanning techniques are well established and widely used. These are discussed at considerable length, while other less well known procedures involving isotopes are more briefly treated. In the field of pathology new developments include technical methods in securing frozen tissue sections, as well as progress in exfoliative cytology and other cytologic techniques. Immunologic techniques, such as immunoelectrophoresis and
Correction of Anemia — Payoffs and Problems
Authors: Giuseppe Remuzzi, Julie R. Ingelfinger
Journal: New England Journal of Medicine (2006)

Anemia develops in most patients with chronic kidney disease, historically often requiring transfusion, with obvious risks. With the advent of recombinant erythropoietin in the late 1980s, it became possible to treat anemia without transfusion, ushering in a new era. It soon became clear that additional considerations were important, such as ensuring adequate iron stores, providing sufficient folate and vitamin B12, and identifying other conditions affecting the hemoglobin level. How best to administer erythropoietin — as well as how best to produce it, given cases of pure red-cell aplasia related to production and administration — were also identified as . . .
DERMATITIS BULLOSA PRATENSIS STRIATA.
Authors: HENRY CORSI
Journal: British Journal of Dermatology (1933)

Journal Article DERMATITIS BULLOSA PRATENSIS STRIATA. Get access HENRY CORSI, M.B., B.Ch.Cantab., F.R.C.S. HENRY CORSI, M.B., B.Ch.Cantab., F.R.C.S. Assistant Physician, St. John's Hospital for Diseases of the Skin; Chief Assistant, Skin Department, St. Bartholomew's Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 45, Issue 12, 1 December 1933, Pages 524–525, https://doi.org/10.1111/j.1365-2133.1933.tb10134.x Published: 01 December 1933
Distribution Rates of Coronary Inflow and Outflow in the Post-mortem Canine Heart
Authors: K. Tamura, M. M. Laks, D. Garner, H. J. C. Swan
Journal: Cardiovascular Research (1969)

A technique is described for the simultaneous determination of coronary inflow and outflow rates in the fresh post-mortem canine heart. No significant change in coronary flow occurred within 1 hr after death. Each coronary outflow system drained from the most proximal coronary artery; however, the most remote coronary arteries contributed to each outflow site. Consequently rudimentary collateral vessels are widespread.