tbuckley/cabot-search huggingface dataset:
AN ACCURATE FORMULA FOR USE IN THE MODIFICATION OF COW'S MILK IN THE ARTIFICIAL FEEDING OF INFANTS
Authors: GEORGE REILY MOFFITT
Journal: JAMA (1910)

Litmus lactose gelatin plates were kept three days at room temperature, then »examined and counted.Lilian.---laeiose-agarplates were incubated at 37 C. for twenty-four hours before »examination.Blood-agar plates were kept three days at 37 C. under anaerobic conditions, secured by passing hydrogen through Now jars containing the plate »cultures, then extract¬ ing the last traces of oxygen with pyrogallie acid and sodium hydrate.Examinations at the end of three days were made and especial attention paid to bemolytic powers of the developing colonies.Oval colonies surrounded by distinct bemolyt ic zones developing from spores in blood-agar corresponded mor¬ phologically and culturally with /,'.aerogehes capsulatus or H.perfringens.Subcultures were made from typical colonies in each stool and furl her study of these confirmed the first impression that the large majority were II.uermjenes cap¬ sulatus.Another paper, purely bactériologie in nature, dealing with all the varieties of spore-forming anaerobic bacteria that have been found, may be published later, and for this reason only such points arc mentioned in Ibis article as bear on the clinical aspects of the relationship bel ween joints and gastro-intestinal disorders.
Computational Protein Design to Reengineer Stromal Cell–Derived Factor-1α Generates an Effective and Translatable Angiogenic Polypeptide Analog
Authors: William Hiesinger, Jose Manuel Perez-Aguilar, Pavan Atluri, Nicole A. Marotta, John R. Frederick, J. Raymond Fitzpatrick, Ryan C. McCormick, Jeffrey R. Muenzer, Elaine C. Yang, Rebecca D. Levit, Li-Jun Yuan, John W. MacArthur, Jeffery G. Saven, Y. Joseph Woo
Journal: Circulation (2011)

Background— Experimentally, exogenous administration of recombinant stromal cell–derived factor-1α (SDF) enhances neovasculogenesis and cardiac function after myocardial infarction. Smaller analogs of SDF may provide translational advantages including enhanced stability and function, ease of synthesis, lower cost, and potential modulated delivery via engineered biomaterials. In this study, computational protein design was used to create a more efficient evolution of the native SDF protein. Methods and Results— Protein structure modeling was used to engineer an SDF polypeptide analog (engineered SDF analog [ESA]) that splices the N-terminus (activation and binding) and C-terminus (extracellular stabilization) with a diproline segment designed to limit the conformational flexibility of the peptide backbone and retain the relative orientation of these segments observed in the native structure of SDF. Endothelial progenitor cells (EPCs) in ESA gradient, assayed by Boyden chamber, showed significantly increased migration compared with both SDF and control gradients. EPC receptor activation was evaluated by quantification of phosphorylated AKT, and cells treated with ESA yielded significantly greater phosphorylated AKT levels than SDF and control cells. Angiogenic growth factor assays revealed a distinct increase in angiopoietin-1 expression in the ESA- and SDF-treated hearts. In addition, CD-1 mice (n=30) underwent ligation of the left anterior descending coronary artery and peri-infarct intramyocardial injection of ESA, SDF-1α, or saline. At 2 weeks, echocardiography demonstrated a significant gain in ejection fraction, cardiac output, stroke volume, and fractional area change in mice treated with ESA compared with controls. Conclusions— Compared with native SDF, a novel engineered SDF polypeptide analog (ESA) more efficiently induces EPC migration and improves post–myocardial infarction cardiac function and thus offers a more clinically translatable neovasculogenic therapy.
JAK2 46/1 haplotype analysis in myeloproliferative neoplasms and acute myeloid leukemia
Authors: H Andrikovics, S Nahajevszky, M Koszarska, N Meggyesi, A Bors, G Halm, S Lueff, N Lovas, Z Matrai, J Csomor, R Rasonyi, M Egyed, J Varkonyi, G Mikala, A Sipos, A Kozma, E Adam, S Fekete, T Masszi, A Tordai
Journal: Leukemia (2010)
Therapeutic Trials in Acute Gouty Arthritis
Authors: M. H. Levin, S. Marcus, D. Strange, R. L. Swezey
Journal: Annals of the Rheumatic Diseases (1956)

Colchicine remains the agent of choice in the treatment of acute gouty arthritis.In recent years valuable additions to the therapeutic armament- arium in this disease include ACTH, cortisone, hydrocortisone acetate, prednisone, and Butazolidin (Wolfson, Hunt, Cohn, Robinson, and Duff, 1950;
THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE
Authors: Kenneth Goodner, D. K. Miller
Journal: The Journal of Experimental Medicine (1935)

Observations are reported which concern the nature of the infectious process resulting from the intraperitoneal injection of mice with virulent pneumococci. The course of the infection has been figuratively reconstructed on the basis of the following data: The rate of bacterial multiplication, the numbers of cells present in the peritoneal cavity, the character of these cells at various stages, and the rate of phagocytosis. The significant alterations in this infectious process brought about by the administration of type specific immune serum are described, and the general significance of the findings discussed with reference to the functions of the immune serum and the rôle of phagocytes in protection.
THE BACTERIOLOGY OF THE MOUTH IN MAORI CHILDREN: Being Part of an Investigation into the Cause of Immunity to Dental Disease in the Maori of the Uriwera Country, N.Z.
Authors: H. P. Pickerill, S. T. Champtaloup
Journal: BMJ (1913)

Iiiglh indlex frequently o2ecurrcd, yet the conditioni was getting worse, and the-weiglit (miiore im-lportant than all) was steadily tendinig downwvard.
Quantitative Radionuclide Angiocardiography
Authors: DAVID L. MALTZ, S. TREVES
Journal: Circulation (1973)

A new method of determining pulmonary-to-systemic flow ratios (Qp/Qs) in patients with left-to-right shunts using radionuclide angiocardiography is described. It involves the analysis of pulmonary time-activity histograms using a gamma-variate model. It appears to be simple, relatively atraumatic, and superior to the methods using C 2 /C 1 ratios because, in addition to accurately detecting the presence of left-to-right shunts, it permits precise quantitation. In the 35 patients studied, it was found that Qp/Qs &lt;1.2 could be separated from Qp/Qs &gt; 1.2 and that when the Qp/Qs is between 1.2 and &lt;3 the shunts could be accurately quantified.
Assessment of Long-acting Synthetic Corticotrophin in Hypersensitive Asthmatics and Normal Subjects
Authors: A. H. El-Shaboury
Journal: BMJ (1968)

The synthetic polypeptide depot-tetracosactrin (Synacthen-Depot) was given to nine steroid-treated asthmatic patients hypersensitive to animal corticotrophin. Eight had a satisfactory increase in plasma and urinary 17-hydroxycorticosteroids (17-OHCS). The remaining patient had been shown previously to have adrenal suppression. None of the patients developed allergic reactions to depot-tetracosactrin, and seven have been receiving regular injections of the polypeptide twice weekly for the past eight months. In 13 normal subjects intramuscular injections of 1 mg. and 0.5 mg. of depot-tetracosactrin and 40 units of corticotrophin-gel were equally potent in raising the plasma 17-OHCS, but depot-tetracosactrin had a significantly longer action than corticotrophin-gel.
The Relation of Passage of Gas and Abdominal Bloating to Colonic Gas Production
Authors: Michael D Levitt
Journal: Annals of Internal Medicine (1996)

Objective: To determine the relation of gas passage and abdominal bloating to the production of gas in the colon. Design: Randomized, double-blind, crossover study of gaseous symptoms during a 1-week period. Setting: A Veterans Affairs medical center. Participants: 25 healthy medical center employees. Intervention: Participants' diets were supplemented with either a placebo (10 g of lactulose, a nonabsorbable sugar), psyllium (a fermentable fiber), or methylcellulose (a nonfermentable fiber). Measurements: All participants were polled for gaseous symptoms (including number of gas passages, impression of increased rectal gas, and abdominal bloating), and five were examined for breath hydrogen excretion. Results: Participants passed gas 10 ± 5.0 times per day (mean ±SD) during the placebo period. A significant increase in gas passages (to 19 ± 12 times per day) and a subjective impression of increased rectal gas were reported with lactulose but not with either of the two fiber preparations. Breath hydrogen excretion, an indicator of hydrogen production in the colon, did not increase after ingestion of either of the fibers. However, a statistically significant (P < 0.05) increase in feelings of abdominal bloating (which the participants perceived as excessive gas in the bowel) was reported with both fiber preparations and with lactulose. Conclusions: The physician should distinguish between excessive rectal gas (which indicates excessive gas production) and feelings of bloating (which are usually unrelated to excessive gas production). Treatment of the former consists of limiting the supply of fermentable material to the colonic bacteria. Symptoms of bloating usually indicate the irritable bowel syndrome, and therapy should be directed accordingly.
Case 61-1964
Authors: Raymond D. Adams, Edward P. Richardson
Journal: New England Journal of Medicine (1964)

Presentation of CaseA thirty-three-year-old printer was admitted to the hospital because of headache and fever.He had been well until fifteen days previously, when a dull headache developed, followed five days later by nausea, vomiting and fever. Penicillin was administered for three days, without improvement, and he entered a hospital, where a lumbar puncture showed a cerebrospinal-fluid pressure of 480 mm.; the fluid contained 633 white cells (10 per cent polymorphonuclear cells and 90 per cent lymphocytes) per cubic millimeter, and the protein was 304 mg. per 100 ml.; a Gram stain of the fluid was negative. Four days . . .
Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice
Authors: Jin-Kyu Park, Mi-Ran Ki, Hye-Rim Lee, Il-Hwa Hong, Ae-Ri Ji, Akihito Ishigami, Se-Il Park, Ji-Min Kim, Hae-Young Chung, Sung-Eun Yoo, Kyu-Shik Jeong
Journal: Hepatology (2009)

Senescence marker protein 30 (SMP30), an important aging marker molecule that is highly expressed in the liver, has been known to protect hepatocytes from apoptosis by the synthesis of vitamin C. To explore the function of SMP30 in liver fibrosis, the effect of SMP30 deficiency on liver fibrosis was investigated in SMP30 knockout (KO) mice. Moreover, the in vivo results were further confirmed by way of hepatic stellate cell (HSC) isolation. We demonstrated that carbon tetrachloride (CCl4)-induced liver fibrosis and the nuclear translocation of p-Smad2/3, the immediate downstream of transforming growth factor beta (TGF-β), were significantly inhibited in the liver of SMP30 KO mice compared with wildtype (WT) mice. We also confirmed that both WT and SMP30 KO HSCs did not express SMP30. Finally, we further confirmed that up-regulation of peroxisome proliferator-activated receptor-gamma (PPAR-γ) caused by a lack of vitamin C was the pivotal factor in the mechanisms for attenuated liver fibrosis of SMP30 KO mice, and feeding with vitamin C restored CCl4-induced liver fibrosis in SMP30 KO mice. Conclusion: Vitamin C deficiency by SMP30 depletion attenuated liver fibrosis by way of up-regulated PPAR-γ expression in SMP30 KO mice. Our results provide, for the first time, the possible mechanisms underlying inhibition of HSC activation associated with vitamin C and PPAR-γ up-regulation in liver fibrosis of SMP30 KO mice. (Hepatology 2010.)
Serum hyaluronate in liver diseases: Study by enzymoimmunological assay
Authors: Thierry Frébourg, Bertrand Delpech, Eric Bercoff, Jacques Senant, Philippe Bertrand, Yves Deugnier, Jacques Bourreille
Journal: Hepatology (1986)

It has been suggested that glycosaminoglycans are involved in the pathogenesis of liver fibrosis. Furthermore, recent studies have reported that one of them, hyaluronate, was mainly taken up and degraded by the liver. Using an enzymoimmunological assay, based on hyaluronate-hyaluronectin interaction, serum levels of hyaluronate were measured in 113 patients with various liver diseases. Patients were divided into six groups according to clinical, biological and histological data: Group 1—alcoholic cirrhosis (n=47) including alcoholic cirrhosis with alcoholic hepatitis (n=24); Group 2—primary biliary cirrhosis (n=21); Group 3—cirrhosis related to viral hepatitis (n=10); Group 4—idiopathic hemochromatosis (n=17); Group 5—alcoholic fatty liver (n=8); and Group 6—viral or drug acute hepatitis (n=10). Ninety-four blood donors were studied as controls. Levels of hyaluronate were found to be strikingly elevated in Group 1 (1,225 ± 1,137 μg per liter), Group 2 (792 ± 739 μg per liter), Group 3 (649 ± 373 (μg per liter), and Group 4 (246 ± 242 μg per liter), whereas patients in Group 5 (94 ± 63 μg per liter) and Group 6 (73 ± 57 μg per liter) had values close to controls (23 ± 17 μg per liter). There was a significant correlation between serum hyaluronate and serum albumin, prothrombin time, factor V concentration and serum γ-globulins. It is suggested that hyaluronate levels reflect both active fibrosis and hepatic failure and may be a quantitative marker of severity of hepatic injury.
Questionnaire Study of Anesthesia Equipment Sterility
Authors: Gale E. Dryden
Journal: JAMA (1968)

To the Editor:—  A review of the literature concerning the potential hazard of cross infection from anesthesia equipment reveals no agreement about the risk involved. Because of this finding a questionnaire was mailed to all directors of anesthesia training programs in the United States.  The questionnaire was designed to evaluate their awareness and concern regarding cross contamination from the anesthesia circle and its parts, the degree of effort made to clean between cases, and the financial value associated with elimination of such contamination hazards.  A total of 253 questionnaires were mailed. Three were returned undelivered. There were 157 responses. Some of those who responded did not answer all of the questions. A summary of the questions and answers is given.   The bacteriological status of the anesthetic absorption system was studied by 82 of 155 who responded.  Of 82 studies, 56 showed organisms grown of which 17 types were
Improvement in the Anemia of Chronic Renal Failure with Fluoxymesterone
Authors: JOSEPH W. ESCHBACH
Journal: Annals of Internal Medicine (1973)

Fluoxymesterone was administered to 14 severely anemic patients with chronic renal failure stabilized with maintenance hemodialysis. Clinically, significant improvement in erythropoiesis was seen within 3 to 6 months of androgen therapy in 13 of the 14 patients, as reflected by a reduction in transfusion requirements and an increase in hematocrit value. The increase in effective erythropoiesis was documented by the erythroid iron turnover and was accompanied usually by either an increase in measurable serum levels of erythropoietin or a reduction in the marrow transit time, suggesting that the androgen acted primarily by stimulating erythropoietin production. This response did not depend on the presence of residual renal tissue. In the doses given (10 mg/day for women; 30 mg/day for men), fluoxymesterone therapy was unassociated with significant toxicity.
It Is Possible
Authors: Melissa D. Aldridge, Diane E. Meier
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Incidental Detection of Multiple Abdominopelvic Splenosis Sites During Tc-99m HMPAO-Labeled Leukocyte Scintigraphy
Authors: Cuneyt Turkmen, Ebru Yormaz
Journal: Clinical Nuclear Medicine (2006)

Splenosis is heterotopic autotransplantation and seeding of splenic tissue, and it can be found anywhere in the abdominal cavity. We present a case of multiple abdominopelvic splenosis in a postsplenectomy patient detected incidentally during Tc-99m HMPAO-labeled leukocyte scintigraphy 30 years after the traumatic event.
Homicides and The Death Penalty
Authors: David Lester
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Studies that have looked at the deterrent effect of the death penalty on the incidence of homicide have compared locales with the death penalty to locales without the death penalty.<sup>1</sup>This comparison is not psychologically meaningful. The death penalty, if it were a deterrent, would be so only in those areas where it is carried out. To have the death penalty in a region, but never to execute anyone, is equivalent to not having a death penalty. This letter reports data on the effect of<i>executions</i>in a given year on the change in the number of homicides from that year to the next year. The locales studied were the United States from 1955 to 1965 (after which there were too few executions by the states for an effective study. The data on executions by state each year and the number of homicides came from publications
Fewer night emergency operations are performed by juniors
Authors: S. Mayor
Journal: BMJ (2003)

The proportion of night time emergency operations that are performed by junior grade surgeons fell from 65% in 1995-6 to 20% in 2002, a new report on perioperative deaths in England and Wales shows.

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But nearly half of emergency operations performed during the night are still carried out on patients anaesthetised by trainees. The fall in the number of …

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Emergency coronary stenting for dissection during percutaneous transluminal coronary angioplasty: Angiographic follow-up after stenting and after repeat angioplasty of the stented segment
Authors: Albert Schömig, Adnan Kastrati, Rainer Dietz, Bernhard Rauch, Franz-Josef Neumann, Hugo H. Katus, Ulrich Busch
Journal: Journal of the American College of Cardiology (1994)
A CASE OF PRIMARY SARCOMA OF THE LIVER
Authors: J. S. Morrow, W. H. McKinstry
Journal: BMJ (1919)

PRIMARY SARCOMA OF THE -LI-VER.treatment,even it rather prolonged, in preference to a formidable operation from wlhich they would naturally shrink.Several of the cases are of three and four years' standing, yet notle of thlose discharged cured have returned, and a few have written letters saying how well they still feel.
Screening of Children with Suspected Congenital Heart Disease
Authors: Frank L. Fletcher
Journal: JAMA (1962)

Experience with "screening" of children with suspected congenital heart disease in a rural community over a period of 8 years demonstrated that the procedures used were safe, effective, and economical. They should become more so with increasing experience. The patients were separated into those needing immediate definitive care, those for whom such care was unavailing, those for whom definitive care could await an optimal time, and those with no indications for such care. No increase in mortality or morbidity could be attributed to the selection of cases. The records of 182 children are included in this study; the salient features are reviewed, and the costs are discussed briefly.
AN OPERATION FOR THE CORRECTION AND PREVENTION OF PARALYTIC GENU RECURVATUM
Authors: Willis C. Campbell
Journal: JAMA (1918)

On account of the mechanical arrangement and location, the unstable paralytic knee remains a difficult problem, while many operative procedures about the ankle and other joints have been most satisfactory. In paralytic genu recurvatum I have employed a procedure which has been successful in one instance and applied in several others too recent for consideration. The object of the measure is to unite the lower third of the patella to the anterior aspect of the tibia just below the knee joint, leaving the upper two-thirds free but articulating with the femoral condyles in extension thus forming a stop joint and mechanically preventing hyperextension. <h3>TECHNIC</h3> A linear incision is made through the skin and superficial structures in the midline for 5 or 6 inches, exposing the patella and the ligamentum patellae. The tendon above the patella is incised by a Z-shaped plastic lengthening (commonly employed in lengthening the Achilles tendon). The
Fat Embolism Prophylaxis with Corticosteroids
Authors: Steven A. Schonfeld, Yongyudh Ploysongsang, Ralph DiLISIO, John D. Crissman, Edward Miller, Dale E. Hammerschmidt, Harry S. Jacob
Journal: Annals of Internal Medicine (1983)

The efficacy of corticosteroid treatment in the prophylaxis of the fat embolism syndrome was evaluated in a prospective, randomized, double-blind study of high-risk patients with long-bone fractures. Using a set of objective diagnostic criteria, we saw a significant difference in the incidence of the syndrome between corticosteroid- (0 of 21) and placebo-treated patients (9 of 41) (p < 0.05). There were no complications related to corticosteroid treatment. No routine laboratory or physical findings reliably predicted the development of the fat embolism syndrome except petechial rash, which occurred only in 5 placebo-treated patients who developed the syndrome. Complement activation was present in all patients studied who had the syndrome (5 of 27) but also in many patients who did not meet our diagnostic criteria, suggesting a multifactorial cause. These data support the prophylactic value of corticosteroid treatment in patients at high risk for the fat embolism syndrome, particularly if several unfavorable predictors are present.
Laboratory-Acquired Histoplasmosis
Authors: Charles G. Spicknall, Ralph W. Ryan, Alvin Cain
Journal: New England Journal of Medicine (1956)

ALTHOUGH naturally acquired histoplasmosis is being recognized with increasing frequency1 there are few reports in the literature of infection with Histoplasma capsulatum acquired in the laboratory. Sulkin and Pike,2 in 1951, summarized 1342 cases of infections presumably acquired as the result of laboratory work in the United States. Approximately a third of these infections have been recorded in the literature; the remainder were discovered by means of a questionnaire mailed to nearly 5000 laboratories. Thirty-nine of these patients died — a mortality of 3 per cent. No cases of histoplasmosis were recorded in this survey.In 1952 Furcolow et al. . . .