Recovery from Colistimethate Nephrotoxicity
Authors: RUSSELL E. RANDALL
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 September 1970Recovery from Colistimethate NephrotoxicityRUSSELL E. RANDALL JR., M.D., F.A.C.P., GEORGE S. BRIDI, M.D., JOHN G. SETTER, M.D., NEWTON C. BRACKETT JR., M.D.RUSSELL E. RANDALL JR., M.D., F.A.C.P.Search for more papers by this author, GEORGE S. BRIDI, M.D.Search for more papers by this author, JOHN G. SETTER, M.D.Search for more papers by this author, NEWTON C. BRACKETT JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-3-491 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Renal failure due to sodium colistimethate has usually been mild and transient (1), although more severe cases have occurred, generally with a fatal outcome (2, 3). We would like to record our observations in a 41-year-old man who developed severe oliguric renal failure after an excessive dose of colistimethate (6.3 mg/kg body weight/day for 7 days) during treatment of an abdominal abscess accompanying regional ileitis. Renal function, which had been normal, deteriorated markedly during the period of treatment with resultant acidosis, hyperkalemia, pulmonary edema, and uremia. Severe oliguria (0 to 240 ml/day) lasted 27 days during which...References1. FEKETYNORMANCLUFF RPL: The treatment of gram-negative bacillary infections with colistin. Ann Intern Med 57:214-228, 1962 LinkGoogle Scholar2. ELWOODLUCASMUEHRCKE CGR: Acute renal failure associated with sodium colistimethate treatment. Arch Intern Med (Chicago) 118:326-334, 1966 CrossrefMedlineGoogle Scholar3. RYANSCHAINUCKHICKMAN KLR: Colistimethate toxicity. JAMA 207:2099-2101, 1969 CrossrefMedlineGoogle Scholar4. KUNIN C: A guide to use of antibiotics in patients with renal disease. Ann Intern Med 67:151-158, 1967 LinkGoogle Scholar5. GOODWINFRIEDMAN NE: The effects of renal impairment, peritoneal dialysis and hemodialysis on serum sodium colistimethate levels. Ann Intern Med 68:984-994, 1968 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Renal Disease Medical College of Virginia Richmond, Va. 23219 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEfficacy of intravenous plus intrathecal/intracerebral ventricle injection of polymyxin B for post-neurosurgical intracranial infections due to MDR/XDR Acinectobacter baumannii: a retrospective cohort studyPolymyxin B Induces Apoptosis in Kidney Proximal Tubular CellsColistin in burn intensive care: Back to the future?Clinical and microbiological efficacy and toxicity of colistin in patients infected with multidrug-resistant gram-negative pathogensRéévaluation de la colistineUse of colistin in treating multi-resistant Gram-negative organisms in a specialised burns unitSystemic colistin use in children without cystic fibrosis: a systematic review of the literatureTreatment With Intrathecal Colistin of a Resistant Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae in the Cerebrospinal FluidPolymyxin antibiotics for gram-negative infectionsTreatment options for multidrug-resistant bacteriaToxicity after prolonged (more than four weeks) administration of intravenous colistin 1 September 1970Volume 73, Issue 3Page: 491-492KeywordsAbscessesEdemaRenal failureSodium Issue Published: 1 September 1970 PDF DownloadLoading ...