tbuckley/cabot-search huggingface dataset:
SYSTEMIC INFECTION COMPLICATING PURULENT MIDDLE EAR DISEASE
Authors: SAMUEL J. KOPETZKY
Journal: JAMA (1924)

Following a preliminary report in February, 1915, 1 there is here presented a detailed study of seventy-five cases of systemic infections complicating or accompanying middle ear disease. The cases are limited to those which came to operation, so that the pathologic conditions presented may be studied in relation to the clinical course, laboratory findings and roentgen-ray examinations. These observations lead to a definite grouping of the cases, each group being a distinct clinical entity, at once defined and comprehensible. Not only does the reclassification of these systemic infections, based on observed pathologic changes, make diagnosis more exact; but it also furnishes us with a more logical basis for the therapy and the management of the given case belonging to one or the other group. It will likewise clarify, and in the future obviate, the great amount of confusion evident in the current literature, wherein case reports of typical and atypical
Computations in extraversion
Authors: C. Fine, R. J. R. Blair
Journal: Behavioral and Brain Sciences (1999)

We make two suggestions with regard to Depue &amp; Collins's (D&amp;C's) target article. First, regarding the functioning of MOC13, we provide data indicating that, contrary to D&amp;C's apparent position, this structure is not necessary for instrumental conditioning. Second, we suggest that D&amp;C's approach would be advanced by reference to formal computational theory, in particular the work of Grossberg. We suggest that an integration of Grossberg's and D&amp;C's models can provide a more complete account of extraversion.
Effusion Immunocytochemistry as an Alternative Approach for the Selection of First-Line Targeted Therapy in Advanced Lung Adenocarcinoma
Authors: Tzu-Hsiu Tsai, Shang-Gin Wu, Yih-Leong Chang, Chen-Tu Wu, Meng-Feng Tsai, Pin-Fei Wei, Chih-Hsin Yang, Chong-Jen Yu, Pan-Chyr Yang, Jin-Yuan Shih
Journal: Journal of Thoracic Oncology (2012)
Doctors in India plan to launch network against corruption and unethical practices
Authors: G. Mudur
Journal: BMJ (2015)

A group of doctors in India have announced plans to launch a campaign to curb what some of its members describe as rampant commercialisation trends and widespread unethical and irrational practices in the healthcare sector across the country.

The group, which includes senior consultants and surgeons in the private healthcare sector, community medicine specialists, and medical college faculty staff, proposed last week to establish a network for ethical, rational, and “decommercialised” healthcare and to urge other like-minded doctors to join the organisation.

The move came amid growing concerns among medical staff that ethical standards in Indian medical practice have fallen alarmingly low. Members of the group cited abundant anecdotal evidence of doctors seeking and paying commissions for referring patients …
The International Association Study Lung Cancer (IASLC) Strategic Screening Advisory Committee (SSAC) Response to the USPSTF Recommendations
Authors: John K. Field, Denise R. Aberle, Nasser Altorki, David R. Baldwin, Carolyn Dresler, Stephen W. Duffy, Peter Goldstraw, Fred R. Hirsch, Jesper Holst Pedersen, Harry J. de Koning, James L. Mulshine, Daniel C. Sullivan, Ming-Sound Tsao, William D. Travis
Journal: Journal of Thoracic Oncology (2014)
Associations between allergies and risk of hematologic malignancies: Results from the VITamins and lifestyle cohort study
Authors: Mazyar Shadman, Emily White, Anneclaire J. De Roos, Roland B. Walter
Journal: American Journal of Hematology (2013)

Immune dysregulations associated with allergies may affect cancer cell biology but studies on the relationship between allergies and risk of hematologic malignancies (HM) yielded inconsistent results. Herein, we used the vitamins and Lifestyle (VITAL) cohort to examine this association. From 2000 to 2002, 66,212 participants, aged 50–76, completed a baseline questionnaire on cancer risk factors, medical conditions, allergies, and asthma. Through 2009, incident HMs ( n = 681) were identified via linkage to the surveillance, epidemiology, and end results cancer registry. After adjustment for factors possibly associated with HMs, a history of airborne allergy was associated with increased risk of HMs (hazard ratio [HR] = 1.19 [95% confidence interval: 1.01–1.41], P = 0.039) in Cox proportional hazards models. This association was limited to allergies to plants/grass/trees (HR = 1.26 [1.05–1.50], P = 0.011) and was strongest for some mature B‐cell lymphomas (HR = 1.50 [1.14–2.00], P = 0.005). Gender‐stratified analyses revealed that the associations between airborne allergies overall and those to plants, grass, and trees were only seen in women (HR = 1.47 [1.14–1.91], P = 0.004; and HR = 1.73 [1.32–2.25], P &lt; 0.001) but not men (HR = 1.03 [0.82–1.29], P = 0.782; and HR = 0.99 [0.77–1.27], P = 0.960). Together, our study indicates a moderately increased risk of HMs in women but not men with a history of allergies to airborne allergens, especially to plant, grass, or trees. Am. J. Hematol. 88:1050–1054, 2013. © 2013 Wiley Periodicals, Inc.
1163-114 Prognostic role of plasma C-reactive protein in heart failure: Results from Val-HeFT
Authors: Inder S Anand, Roberto Latini, Serge Masson, Dianne Judd, YannTong Chiang, Robert Glazer, Elena Morris, Aldo P Maggioni, Gianni Tognoni, Stefano Signorini, Jay N Cohn
Journal: Journal of the American College of Cardiology (2004)
Cognitive Behavior Therapy for Pediatric Obsessive-Compulsive Disorder
Authors: Yanning Wang
Journal: JAMA (2012)

To the Editor: Dr Franklin and colleagues reported that the addition of cognitive behavior therapy (CBT) to serotonin reuptake inhibitor (SRI) treatment was efficacious among participants aged 7 through 17 years who had a primary diagnosis of obsessive-compulsive disorder (OCD) and partial response to SRI medication. However, this study did not address the effect of comorbidity on CBT or SRI treatment. In this study, 59.7% of the participants had 1 or more comorbidities, 21.8% had attention-deficit/hyperactivity disorder (ADHD), and 15.3% had tic disorder. The authors reported no difference in comorbidities or SRI medications in the 3 treatment groups (SRI only, SRI plus instructions in CBT, and SRI plus CBT); however, the P value for Pearson 2 test for tic disorder was .06, which was not statistically significant but still worth consideration. The authors did not do pairwise comparisons to show whether there was a difference in having tic disorder between the SRI-only group (21.4%) and the SRI plus CBT group (4.8%). One pediatric OCD study has shown that several psychiatric comorbid disorders, including ADHD and tic disorder, were associated with a significantly poorer response to open-label SRI treatment. Another study found that, relative to those participants without a psychiatric comorbid disorder, response rates to CBT were significantly lower for patients with comorbid ADHD and those with 1 or more psychiatric comorbid disorders. However, the current study did not look at whether participants in the same treatment group with different comorbidities or SRI medications had similar response rates to the treatment. Because of this, the results cannot be generalized to all children and adolescents with OCD. Pediatric patients with OCD and ADHD may respond to SRI plus CBT treatment differently than patients with comorbid tic disorder or other comorbidities. I encourage the authors to report the treatment response by comorbidity and type of SRI medication to provide health care professions with important information needed to treat pediatric patients with OCD and psychiatric comorbid disorders.
Yale Studies in Family Health Care
Authors: Jerome S. Beloff
Journal: JAMA (1968)

The Family Health Care Project is an experimental attempt to answer the need for a health care system which will bridge the gap between patient needs and available but fragmented health resources. The health care team, which consists of physician, public health nurse, and health aide, coordinates the efforts of medical and allied medical personnel to give comprehensive health care to multiproblem urban families. There are difficulties in creating a coordinated health team, given the traditional role relationships of the doctors, nurses, and other health personnel. After 2 1/2 years of experience with this model, it was possible to develop an effectively functioning health team when communication techniques were improved. The data presented reveal the effect of health team delivery of care on utilization patterns of urban families.
Blood pressure in tenth-grade students: results from the Chicago Heart Association Pediatric Heart Screening Project.
Authors: R A Miller, R B Shekelle
Journal: Circulation (1976)

This report is based on 13,231 tenth-grade students who participated in the Chicago Heart Association Pediatric Heart Screening Project. The blood pressures of these fifteen and sixteen-year-olds were analyzed with respect to sex, race, adiposity, pulse rate, and father's educational attainment. The mean systolic blood pressure was higher in boys than girls by nearly 5 mm Hg, but mean diastolic blood pressure was lower by less than 1 mm Hg. Black tenth-graders had higher mean diastolic blood pressure than whites; the difference in systolic blood pressure was not statistically significant. Adiposity and resting pulse rate were positively correlated with systolic blood pressure and, to a lesser degree, with diastolic blood pressure. After taking adiposity and pulse rate into account, father's educational attainment had a small but statistically significant negative association with diastolic blood pressure in white but not in black students. Nearly 5 percent of students were recalled for a second test because the initial screening blood pressures equaled or exceeded 150 mm Hg systolic or 90 mm Hg diastolic, and almost half of students at the recall examination continued to have pressures of 145/85 or greater.
Bronchopancreatic Fistula Following Traumatic Rupture of the Diaphragm
Authors: Charles L. Cox
Journal: JAMA (1977)

A bronchopancreatic fistula developed in a 14-year-old boy two weeks following transabdominal splenectomy and repair of a ruptured diaphragm. This unusual entity should be suspected when a patient with pancreatitis or pancreatic trauma has pleural complications associated with profuse, frothy sputum. The diagnosis is established by the presence of high levels of amylase in the sputum or by the appearance in the sputum or the bronchi of dye or contrast material injected into the external fistula. The primary goal of treatment, in addition to the management of the thoracic complications, is subdiaphragmatic control of the pancreatic fistula. A brief summary of seven previously reported cases is presented. (<i>JAMA</i>237:1461-1463, 1977)
Genes, Blood and Courage: A Boy Called Immortal Sword
Authors: Arthur W. Nienhuis
Journal: JAMA (1996)

This beautifully written book captures in a rich and multitextured fabric many of the themes of modern medicine and biomedical research during their evolution over the past four decades. It is about a young man who has severe β-thalassemia, an inherited, transfusion-dependent anemia. The patient is now approaching middle age, having survived with the help of a concerned and skilled physician-scientist. Throughout his career in biomedical research, Dr David G. Nathan, chairman of pediatrics at Boston Children's Hospital, has remained dedicated to the survival of this patient, achieved with the tools of modern medicine and science. From the interwoven stories of the patient with a usually fatal disease and the physician-scientist dedicated to understanding mechanisms of this disease and improving its treatment, the reader is afforded many insights into the evolution of modern medicine and the revolution in genetics that has carried us to the threshold of gene therapy for
The Rights of Patients: The Basic ACLU Guide to Patient Rights
Authors: Stanley B. Troup
Journal: JAMA (1992)

The Rights of Patients , by George J. Annas, is the second edition of this text, revised from the 1975 publication The Rights of Hospitalized Patients . This is one of a series of handbooks published in cooperation with the American Civil Liberties Union (ACLU). The author is a professor of law, a respected spokesman for human rights, and a frequent commentator on health law and ethics.  The book is written for the laity, and the language is clear, straightforward, and free of jargon. Definitions generally are precise and helpful.  In his introduction the author states that the most powerful concept shaping the practice of modern medicine is the recognition that patients have human rights and that the recognition of human rights is the only force powerful enough to prevent medicine from becoming an impersonal and dehumanizing industry. Without denying the latent power of human rights and the desire of many of
Raft of public health services is threatened by health bill, say specialists
Authors: Z. Kmietowicz
Journal: BMJ (2012)

The transfer of public health services from the NHS to local authorities is damaging, flawed, and unsafe, says the network Public Health for the NHS, which is made up of more than 500 medical professionals and legal and academic experts.

A report from the network says that the rationale for transferring public health services to local government has never been properly explained and seems to be “more consistent with the aim of shrinking the NHS and commercialising the health system, than it is with any claim to improve public health.”

It says that the Health and Social Care Bill provides no safeguards or guarantees that public health services will be provided as a universal entitlement to all, as under the existing NHS.

The areas of work threatened by the bill include public …
THE BASIS OF ALLERGIC PHENOMENA
Authors: P. J. HANZLIK
Journal: JAMA (1924)

Broadly speaking, allergic phenomena are the manifestations of an altered reaction of the organism, and include all the phenomena of hypersusceptibility. For convenience, they may be divided into two classes, (1) the anaphylactic and (2) the anaphylactoid. Present methods reveal certain features that appear to constitute differences, if not difficulties, in reconciling the two classes of reactions on a common basis. The differences are frequently exaggerated through the employment of vague and loose terminology. Many difficulties arise from lack of sufficient evidence. On the other hand, there are numerous evidences scattered throughout the literature, including some explanations that are worthy of consideration because they help to clarify the nature of these reactions. The important bearing of the subject on biologic phenomena, that is, in understanding the nature of cellular function and responses to different kinds of agents and stimuli, including pharmacologic phenomena, and in therapeutics, has prompted me to summarize
Pancreatin enhanced erosion of and macromolecule release from 2,2-bis(2-oxazoline)-linked poly(ϵ-caprolactone)
Authors: Tommy Tarvainen, Minna Malin, Tanja Suutari, Mikko Pöllänen, Jukka Tuominen, Jukka Seppälä, Kristiina Järvinen
Journal: Journal of Controlled Release (2003)
Pulmonary chemokines and their receptors differentiate children with asthma and chronic cough
Authors: Dominik Hartl, Matthias Griese, Thomas Nicolai, Gernot Zissel, Christine Prell, Nikolaos Konstantopoulos, Rudolf Gruber, Dietrich Reinhardt, Dolores J. Schendel, Susanne Krauss-Etschmann
Journal: Journal of Allergy and Clinical Immunology (2005)
Radionuclide Tagged Red Blood Cells In the Gallbladder
Authors: MARY J. WOOD, D BRUCE HENNIGAN
Journal: Clinical Nuclear Medicine (1984)

During in vivo tagging of red blood cells with Sn PYP and Tc-99m pertechnetate for gastrointestinal bleeding, visualization of the gallbladder occurred 24 hours postinjection. The patient had chronic endstage renal disease with associated anemia and autohemolysis. Hemoglobin from hemolysis is phagocytized by the liver, converted to bilirubin, and excreted by the polygonal cells as a component of bile. Iron and globin are conserved by the body. The appearance of radionuclide in the gallbladder could represent hematobilla, however, it may represent radionuclide bound to the porphyrin portion of the hemoglobin molecule.
Cytogenetic and therapeutic characterization of primary plasma cell leukemia: the IFM experience
Authors: H Avet-Loiseau, M Roussel, L Campion, X Leleu, G Marit, H Jardel, M Dib, O Decaux, T Lamy, M Tiab, P Cony-Makhoul, A Banos, G Lepeu, F Lifermann, M Macro, B Kolb, C Hulin, D Caillot, C Traulle, C Mathiot, B Royer
Journal: Leukemia (2011)
Adjuvant chemotherapy improves survival in early ovarian cancer
Authors: S. Mayor
Journal: BMJ (2003)

Immediate treatment with chemotherapy after surgery significantly improves survival and reduces recurrence of cancer in women with early ovarian cancer, show two major international trials published this week.

The first trial, the international collaborative ovarian neoplasm trial 1, randomly assigned 477 women with early stage epithelial ovarian cancer to receive platinum based adjuvant chemotherapy immediately after surgery or to receive no adjuvant chemotherapy until clinically indicated when further symptoms developed ( Journal of the National Cancer Institute 2003; 95:125-32). It is the largest clinical trial to be carried out in …
The Arm-to-Tongue Circulation Time in Chronic Asthma
Authors: J. D. Cottrell, D. C. Cuddie
Journal: BMJ (1942)

OURtNALtortuous.After the operation the patient did not complain of any more pain, and the tenderness disappeared gradually.The symptoms may have been due to the abscess between the colon and the abdominal wall.A Wassermann test proved negative, and she was discharged on April 4
Spectrum of Proteinuria in Type I and Type II Diabetes
Authors: George Jerums, Mark E Cooper, Ego Seeman, Robin M L Murray, John J McNeil
Journal: Diabetes Care (1987)

We prospectively investigated the evolution of proteinuria in 52 type I diabetics over 7.8 +/- 0.3 (mean +/- SE) yr and in 61 type II diabetics over 6.4 +/- 0.3 yr. Measurements of renal protein clearance were performed serially, and the time course of proteinuria was classified in each subject based on a threshold albumin clearance of 11 nl/s, equivalent to a urinary albumin excretion rate of 30 micrograms/min. The classification based on this threshold yielded four distinct patterns of albuminuria: minimal, intermittent, progressing, and established. These patterns occurred in both type I and type II diabetics independently of the duration of follow-up. This study has identified a pattern of intermittent microalbuminuria that is also associated with transient elevations of transferrin and IgG clearances. The relationship of clinical and biochemical parameters to proteinuria patterns was evaluated. No relationship was detected between proteinuria patterns and glycemic control in either type I or type II diabetics. In type I but not type II diabetics, established proteinuria was associated with higher systolic blood pressure and decreased creatinine clearance. The phase of intermittent proteinuria detected in this study may represent a reversible stage in the development of diabetic nephropathy, but the factors that trigger the transition to progressing proteinuria remain obscure.
A DERMATOSIS OCCURRING AMONG EAST AFRICAN NATIVES
Authors: A. McK. FLEMING, R. S. F. HENNESSEY
Journal: British Journal of Dermatology (1932)

Journal Article A DERMATOSIS OCCURRING AMONG EAST AFRICAN NATIVES Get access A. McK. FLEMING, A. McK. FLEMING Mulago Hospital, Kampala, Uganda Search for other works by this author on: Oxford Academic Google Scholar R. S. F. HENNESSEY R. S. F. HENNESSEY Mulago Hospital, Kampala, Uganda Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 44, Issue 4, 1 April 1932, Pages 173–181, https://doi.org/10.1111/j.1365-2133.1932.tb09589.x Published: 01 April 1932
Diagnosis of Legionnaires' Disease
Authors: KENNETH F. Wagner
Journal: JAMA (1984)

<h3>To the Editor.—</h3> We read with interest the recent review by Zuravleff et al.<sup>1</sup>There are four points we would like to add. Specimens with 25 or more typical rod forms by direct fluorescent antibody (DFA) test were reported as definitely positive, but in the study any number of typical organisms were included as positive. The Centers for Disease Control (CDC) criterion for a positive test is five or more typical fluorescent forms per smear, on all specimens with the exception of lung biopsy tissue, for which 25 or more organisms per smear are required (<i>Legionella</i>Direct Fluorescent Antibody Reagents, product brochure B77, 1982, Biologic Products Programs, Centers for Disease Control, Atlanta). One typical fluorescent form per smear has been suggested to be more sensitive and no less specific than the higher criterion.<sup>2</sup>In our conversation with personnel in the CDC legionnaires' disease testing laboratory, we learned
Activation of a dendritic cell–T cell axis by Ad5 immune complexes creates an improved environment for replication of HIV in T cells
Authors: Matthieu Perreau, Giuseppe Pantaleo, Eric J. Kremer
Journal: The Journal of Experimental Medicine (2008)

The STEP HIV vaccine trial, which evaluated a replication-defective adenovirus type 5 (Ad5) vector vaccine, was recently stopped. The reasons for this included lack of efficacy of the vaccine and a twofold increase in the incidence of HIV acquisition among vaccinated recipients with increased Ad5-neutralizing antibody titers compared with placebo recipients. To model the events that might be occurring in vivo, the effect on dendritic cells (DCs) of Ad5 vector alone or treated with neutralizing antiserum (Ad5 immune complexes [IC]) was compared. Ad5 IC induced more notable DC maturation, as indicated by increased CD86 expression, decreased endocytosis, and production of tumor necrosis factor and type I interferons. We found that DC stimulation by Ad5 IC was mediated by the Fcγ receptor IIa and Toll-like receptor 9 interactions. DCs treated with Ad5 IC also induced significantly higher stimulation of Ad5-specific CD8 T cells equipped with cytolytic machinery. In contrast to Ad5 vectors alone, Ad5 IC caused significantly enhanced HIV infection in DC–T cell cocultures. The present results indicate that Ad5 IC activates a DC–T cell axis that, together with the possible persistence of the Ad5 vaccine in seropositive individuals, may set up a permissive environment for HIV-1 infection, which could account for the increased acquisition of HIV-1 infection among Ad5 seropositive vaccine recipients.
Reply to Drs Heuss and Beglinger
Authors: G. M. Naylor, S. O’Mahony
Journal: Endoscopy (2004)

We thank Dr. Heuss and Dr. Beglinger for their interest in our paper. We would agree, firstly, that sedation forms part of the procedure and does have associated risks, and secondly that complications data should form part of the quality assurance (QA) database. At the time of our data collection, we had a computerized system for endoscopy reporting that included the dose of sedation used, but the nursing staff kept a written record of sedation dose, oxygen saturations, and the need for reversal agents or any other sedation-related complications. We used the system as it stood and collected relevant data by hand, matching written nursing records to printed procedure reports and entering all the QA data manually into a single database. Our aim has since been to computerize this whole process, and we now have nursing pre-assessment, intraprocedural observations, and postprocedural observations recorded on the same computer system and linked to the procedure report. This ensures that any complications occurring within the endoscopy department are picked up. However, as far as we are aware, this type of integrated system is still relatively unusual in everyday practice. Accurate reporting of sedation complications is vital, but as with QA as a whole, it needs effort and resources to ensure success.