tbuckley/cabot-search huggingface dataset:
FOOD AS A CAUSE AND CURE OF DISEASES OF THE NERVOUS SYSTEM
Authors: EPHRAIM CUTTER
Journal: JAMA (1988)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapeutic Pancreatic Endoscopy
Authors: H. Neuhaus
Journal: Endoscopy (2000)

A number of endoscopic interventions have expanded the range of treatment options in symptomatic pancreatic diseases. Early endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic sphincterotomy (ES) appear to be beneficial in patients with severe acute biliary pancreatitis. Endoscopic pancreatic sphincterotomy can be safely performed with high technical success rates in patients with chronic pancreatitis. Routine additional biliary ES or drainage procedures are not apparently necessary. Stenting can be limited to the treatment of dominant pancreatic duct strictures. In patients with sphincter of Oddi dysfunction, temporary placement of pancreatic stents reduces the morbidity associated with ES. Transpapillary or transmural endoscopic drainage achieves resolution of pancreatic pseudocysts in the majority of selected patients. Drainage procedures with endoscopic ultrasound guidance can potentially expand the indications and reduce the procedure-related morbidity. Therapeutic endoscopy should be considered in symptomatic patients with pancreas divisum, as well as in selected children with pancreatic diseases. Most of the published studies on therapeutic pancreatic endoscopy have been conducted retrospectively. Additional prospective controlled trials are warranted to allow further evaluation of the impact of these methods on the clinical outcome in comparison with alternative treatment strategies.
The New National Health Spending Policy
Authors: Rashi Fein
Journal: New England Journal of Medicine (1974)

Abstract The fiscal 1974 federal budget for health, as proposed by the President, cuts back substantially the support for a number of federal programs. These reductions affect Regional Medical Programs, Hill-Burton construction and Community Mental Health Centers, as well as various research, training and education activities. Amendments to Medicare legislation would also reduce federal payments while increasing the proportion of the medical care paid for by patients. Macroeconomic policy needs and cost-benefit evaluations cannot fully explain the reduced federal support. Consideration of the rationales for the budget reductions leads to the view that they stem from a desire to increase the role of the private market in health economic affairs. This view underemphasizes the social benefits of health programs and equity considerations. A failure to recognize these matters has weakened the medical-care community. (N Engl J Med 290:137–140, 1974)
Coronary Artery Disease in Diabetic Patients With Lower-Extremity Arterial Disease: Disease Characteristics and Survival: A report from the Coronary Artery Surgery Study (CASS) registry
Authors: Joshua I Barzilay, Richard A Kronmal, Vera Bittner, Elaine Eaker, Campbell Evans, Eric D Foster
Journal: Diabetes Care (1997)

OBJECTIVE Patients who have diabetes and lower-extremity arterial disease (LEAD) are at an increased risk of dying from coronary artery disease (CAD). This study was undertaken to: 1) define the clinical and arteriographic factors associated with LEAD among diabetic patients; 2) determine the long-term survival and predictors of mortality of diabetic patients with LEAD, compared to those without LEAD; and 3) determine if the presence of LEAD is an independent risk factor for mortality among diabetic patients with CAD. RESEARCH DESIGN AND METHODS A total of 263 diabetic patients from the Coronary Artery Surgery Study (CASS) registry with LEAD, who were ≥ 50 years of age, and who had arteriographically proven CAD, were identified and followed for a mean of 12.8 years. A total of 1,349 comparably aged diabetic patients from the CASS registry with CAD and no evidence of LEAD were followed for an equivalent period of time. RESULTS Compared with diabetic patients without LEAD, diabetic patients with LEAD were characterized by the presence of cerebrovascular disease, a high rate of current smoking, elevated systolic blood pressure, high grades of angina pectoris, and digitalis use. Severity of epicardial CAD and extent of CAD were not independent predictors of the presence of LEAD. On follow-up, diabetic patients with LEAD had significantly higher mortality (mostly cardiovascular) than diabetic patients without LEAD, with a median survival of 8.1 and 10.9 years, respectively. On multivariate analysis, age, the number of significantly narrowed coronary arteries, and the presence of left ventricular dysfunction predicted mortality in both subsets of diabetic patients. Among all the diabetic patients with CAD, the presence of LEAD was an independent risk factor for mortality. CONCLUSIONS Diabetic patients with LEAD have a higher mortality rate (mostly cardiovascular) than diabetic patients without LEAD, despite no apparent anatomic differences in the severity and extent of CAD. This suggests that factors associated with the presence of LEAD, other than the anatomy of the coronary circulation, may play a role in determining survival among diabetic patients with LEAD and CAD.
Corticosteroid Therapy and Unintentional Camouflage
Authors: Nicholas P. Christy
Journal: JAMA (1988)

In this issue ofTHE JOURNALJacobs et al<sup>1</sup>report two patients with inflammatory disease treated with large doses of prednisone for protracted periods who suffered bouts of true addisonian crisis: severe disturbances in electrolyte metabolism and near-fatal outcomes. The authors are to be commended for detecting spontaneously occurring Addison's disease not related provably to or caused by the diseases for which the prednisone was being given. Lacking the classic signs of full-blown primary adrenocortical insufficiency, weakness, weight loss, and dermal hyperpigmentation, the diagnosis of Addison's disease is hard to come by at the best of times.<sup>2</sup>In attempting to treat these two patients, the responsible physicians were not working at the best of times or under ideal circumstances. The reported intermittent changes in weight and strength could have been accounted for by the underlying disease. The administered prednisone, in doses up to 20, 40, and 60 mg/d
Uremic Osteodystrophy
Authors: Wulf F. Pinggera
Journal: JAMA (1972)

A uremic patient with severe osteitis fibrosa and widespread soft tissue calcifications was treated with 24 gm of dried aluminum hydroxide gel daily. After seven weeks of treatment the bone lesions improved substantially and the soft tissue calcifications almost disappeared. Discontinuation of the therapy for several weeks resulted in recurrence of bone disease and the reappearance of soft tissue calcifications. These lesions responded favorably again to the same treatment with aluminum hydroxide.
The Strength of the T Cell Response Against a Surrogate Tumor Antigen Induced by Oncolytic VSV Therapy Does Not Correlate With Tumor Control
Authors: Valérie Janelle, Marie-Pierre Langlois, Pascal Lapierre, Tania Charpentier, Laurent Poliquin, Alain Lamarre
Journal: Molecular Therapy (2014)

Cancer therapy using oncolytic viruses has gained interest in the last decade. Vesicular stomatitis virus is an attractive candidate for this alternative treatment approach. The importance of the immune response against tumor antigens in virotherapy efficacy is now well recognized, however, its relative contribution versus the intrinsic oncolytic capacity of viruses has been difficult to evaluate. To start addressing this question, we compared glycoprotein and matrix mutants of vesicular stomatitis virus (VSV), showing different oncolytic potentials for B16/B16gp33 melanoma tumor cells in vitro, with the wild-type virus in their ability to induce tumor-specific CD8(+) T cell responses and control tumor progression in vivo. Despite the fact that wild-type and G mutants induced a stronger gp33-specific immune response compared to the MM51R mutant, all VSV strains showed a similar capacity to slow down tumor progression. The effectiveness of the matrix mutant treatment proved to be CD8(+) dependent and directed against tumor antigens other than gp33 since adoptive transfer of isolated CD8(+) T lymphocytes from treated B16gp33-bearing mice resulted in significant protection of naive mice against challenge with the parental tumor. Remarkably, the VSV matrix mutant induced the upregulation of major histocompatibility class-I antigen at the tumor cell surface thus favoring recognition by CD8(+) T cells. These results demonstrate that VSV mutants induce an antitumor immune response using several mechanisms. A better understanding of these mechanisms will prove useful for the rational design of viruses with improved therapeutic efficacy.
United Kingdom has its first confirmed case of SARS
Authors: J. Parry
Journal: BMJ (2003)

Chromosome 7 is frequently associated with chromosome aberrations, rearrangements, and deletions. It also contains many important genes, gene families, and disease loci. This brief review attempts to summarise these and other interesting aspects of chromosome 7. With the rapid accumulation of cloned genes and polymorphic DNA fragments, this chromosome has become an excellent substrate for molecular genetic studies.
"A DISPLAY OF FAKIRISM"
Authors: Richard Dewey
Journal: JAMA (1926)

<h3>To the Editor:</h3> —Just after reading in your issue of July 24, page 269, "A Display of Fakirism," I chanced to read in<i>L'Illustration</i>of July 3 a short article on "La supercherie [humbug] du fakirisme." This article, by a French scientist, M. Paul Heuzé, described the demonstration before a body of scientists and journalists in Paris of some of the same acts exhibited by "Dr. Tahra Bey," who had hat pins thrust through his cheeks and across his throat, apparently through the larynx, and who also reclined on the points of nails. Dr. Heuzé insisted that there was no anesthesia in his case. He did not swallow his tongue, go into a cataleptic state or have weights put on. These phenomena, including apparent death, burial and resurrection, are discussed in one of Robert Louis Stevenson's novels.
Rates of respiratory virus-associated hospitalization in children aged &lt;5 years in rural northern India
Authors: Shobha Broor, Fatimah S Dawood, Bharti G Pandey, Siddhartha Saha, Vivek Gupta, Anand Krishnan, Sanjay Rai, Pratibha Singh, Dean Erdman, Renu B Lal
Journal: Journal of Infection (2013)

Though respiratory viruses are thought to cause substantial morbidity globally in children aged <5 years, the incidence of severe respiratory virus infections in children is unknown in India where 20% of the world's children live.During August 2009-July 2011, prospective population-based surveillance was conducted for hospitalizations of children aged <5 years in a rural community in Haryana State. Clinical data and respiratory specimens were collected. Swabs were tested by RT-PCR for influenza and parainfluenza viruses, respiratory syncytial virus (RSV), human metapneumovirus, coronaviruses, and adenovirus. Average annual hospitalization incidence was calculated using census data and adjusted for hospitalizations reported to occur at non-study hospitals according to a community healthcare utilization survey.Of 245 hospitalized children, respiratory viruses were detected among 98 (40%), of whom 92 (94%) had fever or respiratory symptoms. RSV accounted for the highest virus-associated hospitalization incidence (34.6/10,000, 95% CI 26.3-44.7) and 20% of hospitalizations. There were 11.8/10,000 (95% CI 7.9-18.4) influenza-associated hospitalizations (7% of hospitalizations). RSV and influenza virus detection peaked in winter (November-February) and rainy seasons (July), respectively.Respiratory viruses were associated with a substantial proportion of hospitalizations among young children in a rural Indian community. Public health research and prevention in India should consider targeting RSV and influenza in young children.
Senile Psychosis and Pellagra
Authors: Herman Arnold Meyersburg
Journal: New England Journal of Medicine (1945)

SEVERAL patients with psychoses of the senile type have been observed to improve after a period of therapy with niacin, thiamine, riboflavin and substances rich in the vitamin B complex. Review of their records has shown 2 with atypical pellagra. In view of the probable relation of pellagra to the clinically observed psychoses, these cases will be reported. The number of cases observed is not sufficient to warrant a statistical analysis, but the indications are that they are not infrequent.The neuropsychiatric manifestations of pellagra in the early stages of the disorder are vague, consisting of irritability, weakness, lassitude, skeletal . . .
The Gastrointestinal Tract: A Handbook of Roentgen Diagnosis
Authors: Robert S. Sherman
Journal: JAMA (1966)

The second edition of<i>Gastrointestinal Tract</i>, 21 years after the first, again makes available a work initially well received and well regarded by radiologists. Subtitled,<i>A Handbook of Roentgen Diagnosis</i>, it includes an Introduction of 24 pages and is divided into six sections: esophagus, upper gastrointestinal tract, biliary tract, colon, abdomen generally, and findings of particular interest. "Handbook" implies a guide, manual, or reference. This text might better be regarded as a combination of a compact volume and atlas. Certainly the atlas aspect is predominant. Only a few of the 625 photographs are substandard in quality or difficult to understand. The more frequent use of arrows would improve a few of the photographs. Consequently, the atlas or pictorial aspect of this book is outstanding and, to my knowledge, unmatched by any other publication. The Introduction, which attempts to cover the field of roentgenology of the gastrointestinal tract, does accomplish a
Acute Hemolytic Anemia Complicating Infectious Mononucleosis
Authors: Andrew M. Fekete
Journal: JAMA (1965)

INFECTIOUS mononucleosis is a frequent cause for hospitalization. The usual clinical course of the disease is one of gradual and uneventful recovery. The entity can have such protean manifestations, however, that in the absence of the more classical findings, it may not be suspected. Though unusual, an acute hemolytic anemia can complicate the picture.<sup>10</sup>Such a situation can present a very serious medical problem. While approximately only 30 cases have been reported in the American literature, it is conceivable that more would be found if sought for (James, G.W., personal communication, June 6, 1964). In a thorough review of the records at the two major local hospitals, only three cases of this entity were noted in the past five years. The case presented here is one of an infectious mononucleosis complicated by a severe hemolysis which was considered attributable to an autoimmune mechanism. <h3>Report of a Case</h3> A 22-year-old white
Bone Marrow Mononuclear Cell Therapy for Acute Myocardial Infarction
Authors: Robert D. Simari, Carl J. Pepine, Jay H. Traverse, Timothy D. Henry, Roberto Bolli, Daniel B. Spoon, Ed Yeh, Joshua M. Hare, Ivonne Hernandez Schulman, R. David Anderson, Charles Lambert, Shelly L. Sayre, Doris A. Taylor, Ray F. Ebert, Lemuel A. Moyé
Journal: Circulation Research (2014)

To understand the role of bone marrow mononuclear cells in the treatment of acute myocardial infarction, this overview offers a retrospective examination of strengths and limitations of 3 contemporaneous trials with attention to critical design features and provides an analysis of the combined data set and implications for future directions in cell therapy for acute myocardial infarction.
Memorial to Professor E. H. Kettle
Authors: None Balfour, W. G. Ball, A. E. Boycott, S. L. Cummins, None Dawson, H. R. Dean, J. H. Dible, J. B. Duguid, H. L. Eason, F. R. Fraser, G. E. Gask, M. H. Gordon, W. E. Gye, G. Hadfield, J. McIntosh, R. Muir, J. A. Murray, A. J. Orenstein, A. H. Proctor, J. A. Ryle, A. W. Sheen, B. Spilsbury, S. Sprigge, M. J. Stewart, W. W. C. Topley, C. M. Wilson
Journal: BMJ (1937)
A Clinical Lecture on Asthma and its Treatment: Delivered at the Hospital for Consumption, Brompton
Authors: S. Martin
Journal: BMJ (1898)

THE term "asthma" has been somewhat loosely applied to several different pathological conditions and groups of sym- ptoms, the exact nature of which it is important to consider in order to discuss a rational treatment.The term is con- stantly and wrongly used by patients and others to express the dyspncea which accompanies emphysema and chronic bronchitis.This is dyspncea due to pathological changes in the lungs, and is to be distinguished from " cardiac asthma," which is dependent on a condition of the lungs and nervous system induced by a disordered circulation of the blood dependent on disease of the valves or the myocardium; and from "renal asthma," which is possibly to be explained either by the effect of a poison or of disordered circulation on the respiratory centre in the course of disease of the kidneys; and from " pressure dyspncea " dependent on the pressure of anl aneurysm or new growth on the trachea.SPASMODIC ASTHMA.
Gene Expression as a Predictive Marker of Outcome in Stage IIB-IIIA-IIIB Non-Small Cell Lung Cancer After Induction Gemcitabine-Based Chemotherapy Followed By Resectional Surgery
Authors: Rafael Rosell, Enriqueta Felip, Miquel Taron, Joaquim Majo, Pedro Mendez, Maria Sanchez-Ronco, Cristina Queralt, Jose Javier Sanchez, Jose Maestre
Journal: Clinical Cancer Research (2004)

Abstract Purpose: The first suggestions of a relationship between gene mRNA expression and differential sensitivity to gemcitabine/cisplatin are now emerging. ERCC1, RRM1, and XPD are involved in the nucleotide excision repair pathways, and tumor up-regulation of these genes leads to chemotherapy failure. In the present study, we have examined the potential correlation and predictive value of ERCC1, RRM1, and XPD mRNA expression in resected specimens from 67 stage IIB, IIIA, and IIIB non-small cell lung cancer patients treated with neoadjuvant gemcitabine/platinum followed by surgery Experimental Design: ERCC1, RRM1, and XPD expression was quantified using real-time quantitative reverse transcription-PCR. Results: A good correlation was found between mRNA expression levels of the three genes. For RRM1 levels, patients in the bottom quartile had a decreased risk of death compared with those in the top quartile (risk ratio = 0.30; P = 0.033). Median survival for the 17 patients in the bottom quartile was 52 months, whereas for the 15 in the top quartile, it was 26 months (P = 0.018). When the characteristics of these 17 patients were compared with all of the other 50 patients, no differences in initial staging were observed. However, the 17 patients in the bottom quartile had better outcomes, including more radiographic responses (65% versus 54%; P = 0.24), complete resections (94% versus 72%; P = 0.03), lobectomies (71% versus 34%; P = 0.004), and pathological complete responses (29% versus 0%; P = 0.00001) Conclusions: Patients with RRM1 levels in the bottom quartile benefited significantly from gemcitabine/cisplatin neoadjuvant chemotherapy, leading us to conclude that RRM1 mRNA levels should be additionally validated to proceed with tailored chemotherapy.
Diagnosis of intrahepatic metastasis and multicentric carcinogenesis by microsatellite loss of heterozygosity in patients with multiple and recurrent hepatocellular carcinomas
Authors: Osakuni Morimoto, Hiroaki Nagano, Masato Sakon, Yoshiyuki Fujiwara, Terumasa Yamada, Hidewaki Nakagawa, Atsushi Miyamoto, Motoi Kondo, Isao Arai, Tameyoshi Yamamoto, Hideo Ota, Keizo Dono, Koji Umeshita, Shoji Nakamori, Yo Sasaki, Osamu Ishikawa, Shingi Imaoka, Morito Monden
Journal: Journal of Hepatology (2003)
Cost-effectiveness of physician peer leader education and practice-based redesign in managed care*1The pediatric asthma care PORT-II trial
Authors: S. Sullivan, T. Lee, D. Blough, J. Finkelstein, P. Lozano, T. Inui, V. Carey, E. Wagner, A. Fuhlbrigge, K. Weiss
Journal: Journal of Allergy and Clinical Immunology (2004)
Integrative and Comparative Genomic Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas
Authors: Tanguy Y. Seiwert, Zhixiang Zuo, Michaela K. Keck, Arun Khattri, Chandra S. Pedamallu, Thomas Stricker, Christopher Brown, Trevor J. Pugh, Petar Stojanov, Juok Cho, Michael S. Lawrence, Gad Getz, Johannes Brägelmann, Rebecca DeBoer, Ralph R. Weichselbaum, Alexander Langerman, Louis Portugal, Elizabeth Blair, Kerstin Stenson, Mark W. Lingen, Ezra E.W. Cohen, Everett E. Vokes, Kevin P. White, Peter S. Hammerman
Journal: Clinical Cancer Research (2014)

Abstract Purpose: The genetic differences between human papilloma virus (HPV)–positive and –negative head and neck squamous cell carcinomas (HNSCC) remain largely unknown. To identify differential biology and novel therapeutic targets for both entities, we determined mutations and copy-number aberrations in a large cohort of locoregionally advanced HNSCC. Experimental Design: We performed massively parallel sequencing of 617 cancer-associated genes in 120 matched tumor/normal samples (42.5% HPV-positive). Mutations and copy-number aberrations were determined and results validated with a secondary method. Results: The overall mutational burden in HPV-negative and HPV-positive HNSCC was similar with an average of 15.2 versus 14.4 somatic exonic mutations in the targeted cancer-associated genes. HPV-negative tumors showed a mutational spectrum concordant with published lung squamous cell carcinoma analyses with enrichment for mutations in TP53, CDKN2A, MLL2, CUL3, NSD1, PIK3CA, and NOTCH genes. HPV-positive tumors showed unique mutations in DDX3X, FGFR2/3 and aberrations in PIK3CA, KRAS, MLL2/3, and NOTCH1 were enriched in HPV-positive tumors. Currently targetable genomic alterations were identified in FGFR1, DDR2, EGFR, FGFR2/3, EPHA2, and PIK3CA. EGFR, CCND1, and FGFR1 amplifications occurred in HPV-negative tumors, whereas 17.6% of HPV-positive tumors harbored mutations in fibroblast growth factor receptor genes (FGFR2/3), including six recurrent FGFR3 S249C mutations. HPV-positive tumors showed a 5.8% incidence of KRAS mutations, and DNA-repair gene aberrations, including 7.8% BRCA1/2 mutations, were identified. Conclusions: The mutational makeup of HPV-positive and HPV-negative HNSCC differs significantly, including targetable genes. HNSCC harbors multiple therapeutically important genetic aberrations, including frequent aberrations in the FGFR and PI3K pathway genes. Clin Cancer Res; 21(3); 632–41. ©2014 AACR. See related commentary by Krigsfeld and Chung, p. 495