tbuckley/cabot-search huggingface dataset:
Lutembacher's Syndrome Associated with Subacute Bacterial Endocarditis
Authors: Edward R. H. Kurz, Isidore Fischer
Journal: New England Journal of Medicine (1949)

THE following case of Lutembacher's syndrome (interauricular septal defect and mitral stenosis) associated with subacute bacterial endocarditis is considered worthy of comment since it appears to be the fourth such case to be recorded in the medical literature.A forty-seven-year-old man was admitted to the hospital after he had suffered for 2 months from progressively more severe dyspnea, orthopnea and hemoptysis. The past history was entirely irrelevant except for an attack of apparent rheumatic fever 20 years earlier. In the interim he had been in active service in the Royal Canadian Field Artillery and had done work in a woolen . . .
Negative inotropy starts with the ?-adrenoceptor
Authors: E SEPPET
Journal: Cardiovascular Research (2003)

See article by Tavernier et al. [1] (pages 288-296) in dependent signalling pathway, and thereby capable of this issue.reproducing the negative inotropic response qualitatively In this issue of Cardiovascular Research, Tavernier et similar to that observed in human [2], dog [5], and guinea al. describe the effects of b -adrenergic stimulation on pig [6] cardiac preparations by b -AR stimulation.These 3 3 cardiac contractility in mice overexpressing the human data clearly show that the role of b -ARs in cardiac 3 b -adrenoceptor (b -AR) [1].This study is a logical muscle is to initiate negative inotropic influence on cardiac 3 3 sequel to preceding investigations by the same research contraction.The mechanisms of b -AR-mediated attenua-3 3 channel, its stimulation with BRL 37344 brings about
Abstract 997: PKD1-β3-integrin complex increases E-cadherin shedding through MMP-2 and −9 secretion in prostate cancer
Authors: Md. Helal U. Biswas, Cheng Du, Chuanyou Zhang, K.C. Balaji
Journal: Cancer Research (2010)

Abstract Introduction: We have previously reported that Protein Kinase D1 (PKD1), a serine threonine kinase, is down regulated in advanced prostate cancer (PC) and known complex with cell adhesion protein β3-integrin to influence cell motility. Cell motility in facilitated by degradation of extracellular matrix, which is accomplished through secretion of proteins such as Matrix Metalloproteinases (MMPs), which are neutral proteinases that catalyze degradation of various transmembrane and extracellular matrix proteins including E-cadherin at cell surface. Here, we demonstrate the presence of PKD1-β3-integrin complex in PC cells that increases MMP-2 and −9 secretion and consequently enhances E-cadherin shedding. Methods: Protein expression, phosphorylation and secretion studies using PC cell lines were done by western blot analysis or gelatin zymography. Cell proliferation was measured by MTS assay. In silico analysis was done to validate correlation between PKD1 and MMPs expression in human PC. Results: To find out the complex formation among PKD1 and β3-integrin in PC cell, we immunoprecipitated the PKD1 protein and immunoblotted with β3-integrin antibody and observed that the PKD1 and β3-integrin proteins were in same protein complex. Then we found that overexpression of PKD1 also colocalized in PC3 cells and that was suppressed with RGD peptide, a specific β3-integrin inhibitor, treated same cells. Additionally, we found that PKD1 overexpressed cell increased in secretion of MMP-2 and −9 as well as activation of Erk and Akt those were suppressed in RGD peptide treated cells. In contrast, we observed that downregulation of PKD1 by shRNA could suppress the phosphorylation of Erk and Akt as well as MMP-2 and MMP-9 secretion in DU145 cells. Interestingly, PKD1 enhanced the expression of E-cadherin and secretion of extracellular part of E-cadherin (sE-cadherin) in conditioned media of DU145 cells, which was suppressed by treatment by MMP-2 and −9 inhibitors. In addition, suppression of cell proliferation by PKD1 was augmented by recombinant MMP-2 and −9 proteins and rescued by MMP-2 and MMP-9 inhibitor in DU145 cells, suggesting a surprising antiproliferative role for MMP-2 and −9 in PC cells. In silico analysis of publicly available DNA microarray data set derived from human PC confirmed that expression of PKD1 and MMP-2 correlated directly in metastatic PC compared to benign prostate tissue. Conclusions: Our study has identified a novel role of PKD1-β3-integrin complex for secretion of MMP-2 and −9 in prostate cancer, which is associated with E-cadherin shedding. Our data also suggested that the proteins complex limits PC cell proliferation by modulation MMP-2 and −9 secretion. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 997.
F-18 FDG PET/CT Staging of Multiple Myeloma With Diffuse Osseous and Extramedullary Lesions
Authors: Alexis A. Wiesenthal, Ba D. Nguyen
Journal: Clinical Nuclear Medicine (2007)

Multiple myeloma is the most common plasma cell neoplasm, with abnormal clonal proliferation of B cells in bone marrow. Its staging is important for therapeutic management and prognosis. F-18 FDG PET/CT is of proven value in staging and posttherapeutic monitoring multiple myeloma. Through imaging integration, PET provides functional detection of high metabolic lesions whereas CT provides correlated anatomic localization. The authors present a case of multiple myeloma status post chemotherapy and stem cell transplant with diffuse osseous and extramedullary lesions evaluated by PET/CT. The extramedullary involvement concerns the maxillary sinus, thyroid cartilage, mediastinum, retroperitoneum, neuroforamen, and epidura.
Extracellular Lumican Inhibits Pancreatic Cancer Cell Growth and Is Associated with Prolonged Survival after Surgery
Authors: Xinqun Li, Mark A. Truty, Ya'an Kang, Xavier Chopin-Laly, Ran Zhang, David Roife, Deyali Chatterjee, E. Lin, Ryan M. Thomas, Huamin Wang, Matthew H. Katz, Jason B. Fleming
Journal: Clinical Cancer Research (2014)

To evaluate the relevance between lumican expression patterns and the clinical course of patients with pancreatic ductal adenocarcinoma (PDAC), and to investigate the role of lumican in PDAC progression.
Hemodynamic Studies in a Case of Carcinoid Cardiovascular Syndrome
Authors: B. L. CHARMS, P. KOHN, H. I. APPLEBAUM, J. GELLER
Journal: Circulation (1959)

A case of malignant carcinoid metastatic to the liver with the typical features of the carcinoid cardiovascular syndrome has been presented. Hemodynamic data obtained at cardiac catheterization indicated the presence of tricuspid insufficiency, low cardiac output, and slight pulmonary hypertension. Unilateral pulmonary artery occlusion studies were reported that suggest the absence of intrinsic pulmonary vascular disease in this syndrome. The paradox of infrequent instances of significant pulmonary hypertension in the presence of serotonin in the reported cases of carcinoid cardiovascular syndrome was discussed. The effect of reserpine on pulmonary artery pressure was reported.
Diagnosis and Treatment of Seasonal Affective Disorder
Authors: Norman E. Rosenthal
Journal: JAMA (1993)

SELECTED CASE  A 39-year-old novelist presented in October complaining of increasing fatigue and severe writer's block. For a month she had found it increasingly hard to wake up and get going in the morning. Her energy level was low; she was unable to concentrate on her writing and had trouble meeting deadlines. She had gained 2.25 kg and had difficulty avoiding desserts and high-calorie snacks. Whenever possible, she would nap at her desk or vegetate in front of the television. Bills went unpaid, and laundry piled up. She felt disgusted at her incompetence and pessimistic about the future.  A review of her history revealed that from her college years she had had similar difficulties, beginning in fall and winter and lasting until spring. For the last few winters, these episodes had been getting worse. During the spring, she would feel alive again—unusually energetic and euphoric, highly productive, and needed little
Weight Loss Reduces C-Reactive Protein Levels in Obese Postmenopausal Women
Authors: André Tchernof, Amy Nolan, Cynthia K. Sites, Philip A. Ades, Eric T. Poehlman
Journal: Circulation (2002)

Background — C-reactive protein (CRP) has been proposed as an independent risk factor for cardiovascular disease and has been positively associated with body weight and body fatness. We examined the hypothesis that weight loss would reduce plasma CRP levels in obese postmenopausal women. Methods and Results — In a sample of 61 obese (body mass index, 35.6±5.0 kg/m 2 ), postmenopausal women (age, 56.4±5.2 years), we found that plasma CRP levels were positively associated with dual x-ray absorptiometry–measured total body fatness ( r =0.36, P &lt;0.005) and CT-measured intra-abdominal body fat area ( r =0.30, P &lt;0.02). Significant correlations were also found between plasma CRP and triglyceride levels ( r =0.33, P &lt;0.009) and glucose disposal measured by the hyperinsulinemic-euglycemic clamp technique ( r =−0.29, P &lt;0.03). Twenty-five of the 61 women tested at baseline completed a weight loss protocol. The average weight loss was 14.5±6.2 kg (−15.6%, P &lt;0.0001), with losses of 10.4±5.4 kg fat mass (−25.0%, P &lt;0.0001) and 2.8±1.4 kg fat-free mass (−6.0%, P &lt;0.0001). Visceral and subcutaneous fat areas were reduced by −36.4% and −23.7%, respectively ( P &lt;0.0001). Plasma CRP levels were significantly reduced by weight loss: average −32.3%, from 3.06 (+0.69, −1.29) to 1.63 (+0.70, −0.75) μg/mL ( P &lt;0.0001, medians and interquartile differences). Changes in body weight and in total body fat mass were both positively associated with plasma CRP level reductions. Conclusions — Adiposity was a significant predictor of plasma CRP in postmenopausal women on a cross-sectional basis. Moreover, caloric restriction–induced weight loss decreased plasma CRP levels. Weight loss may represent an important intervention to reduce CRP levels, which may mediate part of its cardioprotective effects in obese postmenopausal women.
THE SEMEOLOGY OF THE ATTITUDE AND MOTOR STATE IN CHILDREN.
Authors: SAMUEL W. KELLEY
Journal: JAMA (1899)

The ailing child tells us little in words. Under 2½ years he tells us nothing of his symptoms. Even in children who talk, sensations are likely to be unnoticed or ill described or wrongly referred. Therefore, when we examine an infant or young child, we expect nothing from subjective symptoms. This makes it the more important that objective symptoms be closely studied and correctly interpreted by the pediatrist.  I would not be understood as belittling the importance of learning the history of a case. I have no patience with the self-confident clinician who places so much reliance in his own learned touch and omniscient glance that he scorns to listen to the history of a case, but proceeds at once to divine a diagnosis.  Much may often be learned from the child's attendant: his name, age, sex, heredity, residence, surroundings—as to hygiene—feeding, previous illness or injuries, onset and duration of
Drug-induced liver injury: Interactions between drug properties and host factors
Authors: Minjun Chen, Ayako Suzuki, Jürgen Borlak, Raúl J. Andrade, M Isabel Lucena
Journal: Journal of Hepatology (2015)

Idiosyncratic drug-induced liver injury (DILI) is a common cause for drug withdrawal from the market and although infrequent, DILI can result in serious clinical outcomes including acute liver failure and the need for liver transplantation. Eliminating the iatrogenic "harm" caused by a therapeutic intent is a priority in patient care. However, identifying culprit drugs and individuals at risk for DILI remains challenging. Apart from genetic factors predisposing individuals at risk, the role of the drugs' physicochemical and toxicological properties and their interactions with host and environmental factors need to be considered. The influence of these factors on mechanisms involved in DILI is multi-layered. In this review, we summarize current knowledge on 1) drug properties associated with hepatotoxicity, 2) host factors considered to modify an individuals' risk for DILI and clinical phenotypes, and 3) drug-host interactions. We aim at clarifying knowledge gaps needed to be filled in as to improve risk stratification in patient care. We therefore broadly discuss relevant areas of future research. Emerging insight will stimulate new investigational approaches to facilitate the discovery of clinical DILI risk modifiers in the context of disease complexity and associated interactions with drug properties, and hence will be able to move towards safety personalized medicine.
A Case of Hodgkin's Disease in Childhood.
Authors: A. W. Branwood, E. L. Smith, T. E. Anderson
Journal: British Journal of Dermatology (1963)

Journal Article A Case of Hodgkin's Disease in Childhood. Get access A. W. Branwood, A. W. Branwood Aberdeen Search for other works by this author on: Oxford Academic Google Scholar E. L. Smith, E. L. Smith Aberdeen Search for other works by this author on: Oxford Academic Google Scholar T. E. Anderson T. E. Anderson Aberdeen Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 75, Issue 5, 1 May 1963, Pages 221–222, https://doi.org/10.1111/j.1365-2133.1963.tb13553.x Published: 01 May 1963
A new method using a polyglycolic acid monolayer patch to shield the mucosal defect after endoscopic submucosal dissection
Authors: Masakatsu Nakamura, Hisakazu Shiroeda, Tomomitsu Tahara, Tomoyuki Shibata, Tomiyasu Arisawa
Journal: Endoscopy (2014)

Recently, an endoscopic shielding method using polyglycolic acid (PGA) sheets (Neoviel, Gunze Co., Kyoto, Japan) and fibrin glue (Bolheal, Kaketsuken, Kumamoto, Japan) has been reported [1] [2]. It is difficult to stretch a PGA sheet out as a monolayer during an endoscopic procedure because the sheets are very thin and their stickiness increases when wet. Therefore, in these previous reports, the mucosal defects have been covered with several strips of PGA [1] [2]. Here, we report a new method that can be used to cover a gastric mucosal defect following endoscopic submucosal dissection (ESD) with just a monolayer of PGA.
Ovarian toxicity and carcinogenicity in eight recent National Toxicology Program studies.
Authors: R R Maronpot
Journal: Environmental Health Perspectives (1987)

Ovarian toxicity and/or carcinogenicity has been documented for at least eight chemicals recently tested in National Toxicity Program prechronic and chronic rodent studies. The chemicals that yielded treatment-related ovarian lesions were 1,3-butadiene, 4-vinylcyclohexene, vinylcyclohexene deipoxide, nitrofurantoin, nitrofurazone, benzene, delta-9-tetrahydrocannabinol, and tricresylphosphate. Typical nonneoplastic ovarian changes included hypoplasia, atrophy, follicular necrosis, and tubular hyperplasia. The most commonly observed treatment-related neoplasms were granulosa cell tumors and benign mixed tumors. A relationship between antecedent ovarian hypoplasia, atrophy, and hyperplasia and subsequent ovarian neoplasia is supported by some of these National Toxicology Program studies. Pathologic changes in other tissues such as the adrenal glands and uterus were associated with the treatment-related ovarian changes.
Actinomycosis of Pericardium
Authors: Kanwal Mohan
Journal: JAMA (1974)

ACTINOMYCOSIS is a progressive granulomatous disease with focal or systemic manifestations characterized by a tendency to produce multiple draining sinuses. 1 It is an uncommon infection, involving the heart in less than 2% of reported cases. 2 Heart disease is usually secondary to extension of primary thoracic actinomycosis. When the heart is involved, 42% of the patients have cardiac symptoms, with congestive heart failure predominating. 3 We present a case of actinomycotic purulent pericarditis and congestive heart failure in which the patient required pericardiectomy for restoration of normal cardiac function.  Report of a Case  A 51-year-old white woman was admitted with shortness of breath of two days' duration. She gave a history of low-grade temperature for the past two weeks and cough, nausea, and vomiting for the past four days. She was never hospitalized before except for tonsillectomy in early childhood.  The patient was acutely ill, with shortness of breath;
A field study of the ventilatory response to ambient temperature and pressure in sport diving.
Authors: F L Muller
Journal: British Journal of Sports Medicine (1995)

This study reports on the relationship between minute ventilation (VE) and environmental variables of temperature (T) and pressure (P) during open water diving. The author conducted a total of 38 dives involving either a light (20 dives) or a moderate (18 dives) level of physical activity. Within each of these groups, P and T taken together accounted for about two thirds of the variance in the VE data. A very significant increase in VE was observed as T decreased (1 < T(degrees C) < 22), and the magnitude of this increase at a given pressure level was similar in the 'light' and the 'moderate' data sets. A second order observation, particularly notable at lower temperature, was the decrease in VE with increasing pressure under conditions of light work. Empirical functions of the from VE = A+B/P n[1 + exp(T - 8)/10], where A, B, and n are adjustable variables, could accommodate both data sets over the whole range of T and P. These results are the first obtained under actual diving conditions to provide evidence for interactions between P, T, and VE. Understanding the physiological mechanisms by which these interactions occur would assist in appreciation of the limitations imposed on scuba divers by the environmental conditions as they affect their ventilatory responses.
Royal College battles for more women surgeons
Authors: R. Woodman
Journal: BMJ (1999)

The Royal College of Surgeons has announced plans to increase the number of women consultants but it will be many years before domination by men comes to an end.

Currently, only 5% of the United Kingdom's 4190 consultant surgeons are women. The college wants to double this to 10% within five years and double it again to at least 20% by 2009.

“These are ambitious but …
CONTINUOUS RIGHT VENTRICULAR APICAL PACING MIGHT AFFECT ON LEFT VENTRICULAR SYSTOLIC AND DIASTOLIC FUNCTION
Authors: Takashi Yamada, Takeshi Arita, Masao Ooshima, Kohtaroh Okamoto, Shouji Fujiwara, Hiroyuki Johno, Takahiro Murata
Journal: Journal of the American College of Cardiology (2011)
The Mosquito Theory in Text-Books.
Authors: Walter D. McCaw
Journal: JAMA (1905)

Washington, D. C., Sept. 29, 1905. <h3>To the Editor:</h3> —The proof that yellow fever is transmitted by the bite of infected mosquitoes of a particular variety was so promptly accepted by the medical profession of America and Europe, and time has so amply demonstrated the truth and completeness of Walter Reed's conclusions that it seems almost incredible that American text-books for students and practitioners of medicine in the present year should teach the theory of Sanarelli and either omit or fail to make clear what is one of the greatest medical discoveries of the age. From the splendid "Medical Diagnosis" of Musser, last edition, Lea Brothers &amp; Co., I quote: "Yellow Fever.—The infection which we are about to consider is the latest of the epidemic and contagious disorders for which a definite causal micro-organism has been discovered.... The specific micro-organism is<i>B. icteroides</i>described by Sanarelli." A brief description of
Screening for <i>Chlamydia trachomatis</i>
Authors: Rachael Jones, Fiona Boag
Journal: BMJ (2007)

News p 1479 

This month the chief medical officer of England published the report of an expert advisory group on Chlamydia trachomatis , which highlighted the need for immediate action to reduce the prevalence of chlamydia infection and the morbidity associated with it.1 Chlamydia is the most prevalent, treatable sexually transmitted infection in the United Kingdom and has serious sequelae, including pelvic inflammatory disease, infertility, ectopic pregnancy, and neonatal infections. All these conditions, except for infertility, have been shown to be preventable if chlamydia trachomatis is treated in its asymptomatic phase. The expert group is proposing an education campaign to increase awareness of chlamydia infection coupled with opportunistic screening of asymptomatic sexually active young women.

The advisory group's main recommendations are to offer testing to all men and women with symptoms of infection, all attenders at genitourinary medicine clinics, and women seeking terminations of pregnancy and to screen opportunistically sexually active women aged under 25 and those over 25 with …
Anti-Saccharomyces cerevisiae antibodies in twins with inflammatory bowel disease
Authors: J Halfvarson
Journal: Gut (2005)

<b>Background and aims:</b> An increased occurrence of anti-<i>Saccharomyces cerevisiae</i> antibodies (ASCA) is reported in unaffected members of families with Crohn's disease. Whether ASCA is a familial trait due to genetic factors or is caused by exposure to environmental factors is unknown. To assess the genetic influence of ASCA we studied its occurrence in a twin population. <b>Patients and methods:</b> ASCA were analysed in 98 twin pairs with inflammatory bowel disease and were related to clinical phenotype and CARD15/NOD2 genotype. <b>Results:</b> ASCA were more common in Crohn's disease than in ulcerative colitis (40/70 (57%) twins <i>v</i> 5/43 (12%) twins). Associations with ileal Crohn's disease, stricturing/penetrating behaviour, and young age, but not CARD15/NOD2 were confirmed. ASCA were found in 1/20 (5%) healthy siblings in discordant monozygotic pairs with Crohn's disease compared with 7/27 (26%) in discordant dizygotic pairs. Using the intraclass correlation coefficient (ICC), no agreement in ASCA titres was observed in discordant twin pairs with Crohn's disease, in monozygotic (ICC = −0.02) or dizygotic (ICC = −0.26) pairs. In contrast, strong agreement was seen within concordant monozygotic twin pairs with Crohn's disease (ICC = 0.76). <b>Conclusions:</b> These findings question the concept of ASCA as a marker of genetic susceptibility for Crohn's disease. The agreement in ASCA titres within concordant monozygotic twin pairs with Crohn's disease, suggests that the level of increase is genetically determined. We propose that ASCA are a marker of a response to an environmental antigen and that a specific gene(s) other than CARD15/NOD2 determines the level of response and perhaps also specific phenotypic characteristics.
The Internal Struggle Between the Wish to Die and the Wish to Live: A Risk Factor for Suicide
Authors: Gregory K. Brown, Robert A. Steer, Gregg R. Henriques, Aaron T. Beck
Journal: American Journal of Psychiatry (2005)

OBJECTIVE: This study attempted to assess whether an index of the difference between the wish to die and the wish to live constitutes a risk factor for suicide. METHOD: A study group of 5,814 patients, including 44 who committed suicide (0.8%), were recruited from a psychiatric outpatient clinic. Structured diagnostic interviews and clinician ratings of the wish to live and wish to die were conducted. The outcome variable was the occurrence of suicide, as indicated on death certificates. RESULTS: A dichotomized index score of the difference between the wish to live and the wish to die yielded a hazard ratio of 6.51 for suicide. This index contributed a unique risk for suicide after the authors controlled for age, psychiatric hospitalization, suicide attempts, bipolar disorder, major depressive disorder, and unemployment status. CONCLUSIONS: The difference between the wish to die versus the wish to live is a unique risk factor for suicide.