tbuckley/cabot-search huggingface dataset:
The potential role for probiotic yogurt for people living with HIV/AIDS
Authors: Gregor Reid
Journal: Gut Microbes (2010)

In demonstrating that it is feasible to create a community-run kitchen that produces probiotic yogurt, and that this can contribute to the health of people with HIV/AIDS, we embellished the 2001 Food and Agriculture Organization (FAO) and World Health Organization (WHO) Report on Probiotics that recommended efforts be made to take probiotics to developing countries. We proved that driven by humanitarian goals not profit, probiotic yogurt can be produced in the world's poor regions. This food can be safely consumed by HIV/AIDS subjects, and in many of them benefits can be accrued in gut health, nutritional and potentially immune status. Such outcomes have a scientific rationale, many social implications, and perhaps most importantly raise the question, why have developed countries not tried harder to bring nutrition-based probiotics to people in need?
Elevated serum levels of soluble CD30 are associated with atopic dermatitis, but not with respiratory atopic disorders and allergic contact dermatitis
Authors: W. DUMMER, E‐B. BRÖCKER, B.C. BASTIAN
Journal: British Journal of Dermatology (1997)

Type 2 helper T‐cell immune responses can be demonstrated in the human atopic disorders atopic dermatitis and allergic asthma/rhinoconjunctivitis. The CD30 (Ki‐1) antigen, originally described on Hodgkin and Reed‐Sternberg cells, has recently been proposed as a marker of T cells with potent B‐cell helper activity producing IL‐5 and γ‐IFN, as well as on CD4+ and CD8+ T cells with a Th2 cytokine profile. As a soluble form of CD30 (sCD30) is released by CD30+ cells in vivo, we studied its clinical significance in atopic disorders compared with allergic contact dermatitis and healthy controls. Elevated sCD30 levels were associated with atopic dermatitis (P < 0.0001), but not with respiratory atopic disorders or allergic contact dermatitis. sCD30 levels in patients with atopic dermatitis were independent of serum IgE. The particular occurrence of serum sCD30 in patients with atopic dermatitis indicates a special regulatory function of CD30+ cells in this disease.
In the Eye's Mind: Vision and the Helmholtz-Hering Controversy
Authors: Thomas R. Hedges
Journal: JAMA (1995)

<i>In the Eye's Mind</i>discusses the controversies regarding vision between Herman von Helmholtz and Ewald Hering that took place between 1840 and 1920. These two German physicians, pioneers and giants in the fields of physiological optics and visual physiology, were founders of schools of research and teaching in Germany at a time when there was a highly competitive atmosphere setting the stage for a rapid expansion of knowledge in all scientific fields. This book centers around their research and, from this, their interpretation of vision, especially visual or spatial perception and color vision. Helmholtz invented the ophthalmoscope in 1851. This, and his research in muscle metabolism and conservation of energy, established him as the Wunderkind of German science and medicine. His genius expressed itself in physiology, physiological optics, and physics. Hering is best remembered in ophthalmology for his research and investigation into oculomotor physiology and his law of reciprocal innervation
Nephrotoxicity Associated With the Use of Cephaloridine
Authors: Alan R. Hinman
Journal: JAMA (1967)

CEPHALORIDINE, a semisynthetic cephalosporin derivative which has recently been introduced for clinical evaluation,<sup>1-4</sup>has several advantages over cephalothin. It is a more potent agent in vitro, it is more soluble and causes less pain when injected, blood levels are higher, and less frequent injections are necessary due to slower renal clearance.<sup>5,6</sup>Possible disadvantages include less resistance to hydrolysis by staphylococcal beta-lactamase<sup>7,8</sup>and greater nephrotoxicity.<sup>4,5,9,10</sup>This report presents the case of a severely debilitated man infected with<i>Klebsiella</i>organisms, whose death was associated with uncontrolled infection and a nephrotoxic reaction to large doses of cephaloridine given intravenously. <h3>Report of a Case</h3> A 53-year-old white man was admitted to the hospital on Jan 6, 1965, complaining of weakness and shakiness of three weeks' duration and dyspnea, productive cough, chills, and fever for one week. Significant history included pulmonary tuberculosis 20 years previously and severe, chronic alcoholism. Physical examination
CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma
Authors: Monica Casucci, Benedetta Nicolis di Robilant, Laura Falcone, Barbara Camisa, Margherita Norelli, Pietro Genovese, Bernhard Gentner, Fabiana Gullotta, Maurilio Ponzoni, Massimo Bernardi, Magda Marcatti, Aurore Saudemont, Claudio Bordignon, Barbara Savoldo, Fabio Ciceri, Luigi Naldini, Gianpietro Dotti, Chiara Bonini, Attilio Bondanza
Journal: Blood (2013)
Leave the quacks alone
Authors: T. Dalrymple
Journal: BMJ (2012)

Joseph Sampson Gamgee (1828-1886) was one of three brothers all of whom made it into the Valhalla of British posthumous eminence, the Dictionary of National Biography . A surgeon, he is remembered today mainly for the absorbent dressing that he invented and whose use he advocated; he also had a quarrel with Joseph Lister over antisepsis. He was a contemporary of Lister’s at medical school and went on to examine Lister’s methods, which he praised though not without reservation. Lister took this badly, as if he who was not wholly for him was wholly against him. This is not a completely uncommon human trait, as anyone who has ever sat on a hospital committee will know. 

Gamgee had been a surgeon in Malta …
Major UK research funding bodies take encouraging steps in registering and publishing trials
Authors: K. Chinthapalli
Journal: BMJ (2013)

An impressive 98% of studies funded by the National Institute for Health Research Health Technology Assessment (HTA) Programme are published.1 To put this into context, I contacted the Medical Research Council (MRC) and the three largest medical charities that support research—the Wellcome Trust, Cancer Research UK, and the British Heart Foundation.

They all responded …
We are asking more questions about NICE appraisal of Tamiflu
Authors: M. Rawlins
Journal: BMJ (2012)

Dear Fiona

Thank you for your kind words as my tenure of office draws to a close. To have had the opportunity to chair NICE, since its inception, has been the most rewarding part of my professional career. Any success, however, has been a result of the commitment and expertise of the staff, the massive contributions of the professions, as well as (of course) support from the BMJ .

Your premise that NICE does not, in its technology appraisals programme, require access to all clinical trial data is wrong. On the contrary, we require full access to all the information that is available to marketing authorisation holders of medicines when they are subject to a NICE technology appraisal. The medical director of the company involved in making an evidence submission to NICE is asked to sign a declaration to confirm “that all relevant data pertinent to the technology appraisal has been disclosed to the Institute.” Pharmaceutical physicians are very well aware of their obligations, and if a medical director were knowingly to …
DIAGNOSIS AND TREATMENT OF STERILITY IN WOMEN
Authors: S. Forsdike
Journal: BMJ (1928)

THz BRI' .~~~~~~~~~~~~rW'IA mta exist as will allow impregnation, but will not allow healtlhy placentation, so, that a miscarriage results.After this outline of the principles of diagnosis we cani consider tlio broad lines of treatment.11. TREATMENT.It is important first to recognize the conditions in whicl sterility is incurable.For when this is the case it is mieli better that thei patienit and her husband slhould kniow anid aceeept tle3 truth thlan that they sho-old conitiniue in a state of alternating hope and disappointment.Undler-developmenlt.-There are minor degrees of underdevelopment whiclh, though unfavourable, are not hopeless.Anl undersized uterus associated with infrequient and scanty mienstruation may represent a delayed rather than an arlrested developmenit.In such a case the stimulus of marriage is probably the most successful treatment.In addition, the endocrine funcLion may be assisted by the administration of thyroid and ovarian products.Thyroid extract can quite well be given by the mouth, but the same cannot be said of ovarian extract, the properties of which appear to be destroyed in the stomach.It should there- fore be given by the hypodermic injection of freshly prepared ovarian substance.The implantation of ovaries by surgical operation has been advocated anad practised; but the recorded results are not such as to lead me to recommend the procedure.
Intraductal optical coherence tomography during endoscopic retrograde cholangiopancreatography for investigation of biliary strictures
Authors: M. Arvanitakis, L. Hookey, G. Tessier, P. Demetter, N. Nagy, A. Stellke, V. De Maertelaer, J. Devière, O. Le Moine
Journal: Endoscopy (2009)

Background and study aims: Optical coherence tomography (OCT) uses infrared light reflectance to produce high-resolution cross-sectional tissue images. The aim of this study was to demonstrate the feasibility of biliary intraductal OCT during endoscopic retrograde cholangiopancreatography (ERCP) and to assess the potential of the method to detect malignant biliary strictures.
Calcium and Cardiac Arrest
Authors: ALFRED L. GEORGE
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 March 1987Calcium and Cardiac ArrestALFRED L. GEORGE JR., M.D., BENJAMIN P. FOLK III, M.D., PAMELA L. CRECELIUS, R.N. W., BARTON CAMPBELL, M.D.ALFRED L. GEORGE JR., M.D.Search for more papers by this author, BENJAMIN P. FOLK III, M.D.Search for more papers by this author, PAMELA L. CRECELIUS, R.N. W.Search for more papers by this author, BARTON CAMPBELL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-3-472_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Stempien and coworkers (1) recently reviewed the potential deleterious effects of calcium chloride administration during cardiopulmonary resuscitation. They cited retrospective data from their institution and from one published series showing a reduced survival rate in patients who received calcium for prehospital cardiac arrest. We want to share our experience with the use of calcium in hospitalized patients having cardiopulmonary resuscitation and offer an explanation for the apparent negative effect of calcium administration on survival.Between 1 July and 31 December 1985, 140 consecutive inpatients given cardiopulmonary resuscitation at Saint Thomas Hospital were prospectively identified and evaluated. Information...References1. STEMPIENKATZMESSINEO AAF. Calcium and cardiac arrest. Ann Intern Med. 1986;105:603-6. LinkGoogle Scholar2. STUEVENTHOMPSONAPRAHAMIANDARIN HBCJ. Use of calcium in prehospital cardiac arrest. Ann Emerg Med. 1983;12:136-9. CrossrefMedlineGoogle Scholar3. STUEVENTHOMPSONAPRAHAMIANTONSFELDTKASTENSON HBCDE. Lack of effectiveness of calcium chloride in refractory asystole. Ann Emerg Med. 1985;14:630-2. CrossrefMedlineGoogle Scholar4. STUEVENTHOMPSONAPRAHAMIANTONSFELDTKASTENSON HBCDE. The effectiveness of calcium chloride in refractory electromechanical dissociation. Ann Emerg Med. 1985;14:626-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Saint Thomas Hospital and Vanderbilt University Medical Center Nashville, TN 37232 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe management of electromechanical dissociation 1 March 1987Volume 106, Issue 3Page: 472-473KeywordsCalciumCardiopulmonary resuscitationChloridesHeartInpatients Issue Published: 1 March 1987 PDF DownloadLoading ...
Dutch GPs are set to strike over 10% cuts to primary care budget
Authors: T. Sheldon
Journal: BMJ (2011)

<h3>Background</h3> To evaluate the efficacy of botulinum toxin A (BoNT-A) in reducing photophobia and dry eye symptoms in individuals with chronic migraine. Additionally, we aimed to evaluate tear film volume as a potential contributor to symptoms in these patients. <h3>Methods</h3> Retrospective review of 76 patients who received BoNT-A for chronic migraine between 23 August 2017 and 13 December 2017 at the Miami Veterans Affairs Medical Center Neurotoxin Clinic. Demographic data and all comorbidities were queried via chart review. Standardised validated surveys were administered to assess symptoms prior to and after BoNT-A injection. Preinjection tear volumes were obtained using the phenol red thread (PRT) test. <h3>Results</h3> Preinjection migraine, photophobia and dry eye symptom scores were all significantly correlated, p&lt;0.05, and none were associated with preinjection PRT results. After BoNT-A, improvements in migraine, photophobia and dry eye symptoms were also significantly correlated, p&lt;0.05 and similarly did not associate with preinjection PRT results. Photophobia scores significantly improved following BoNT-A, while dry eye symptoms significantly improved in those with severe symptoms at baseline (DEQ-5 score ≥12), p=0.027. In logistic regression analysis of all individuals with dry eye symptoms (DEQ-5 ≥6), individuals with more severe dry eye symptoms were more likely improve, OR 1.27, 95% CI 1.06 to 1.51, p&lt;0.01. <h3>Conclusions</h3> BoNT-A significantly improved photophobia in patients being treated for migraine and also improved dry eye symptoms in patients with severe symptoms at baseline, independent of baseline tear film volume. These improvements may be due to modulation of shared trigeminal neural pathways.
John Mark Gibson
Authors: T. Julian
Journal: BMJ (2011)

John Mark Gibson (“Mark”) was an exceptionally talented and modest neurologist who devoted his working life to the study and treatment of movement disorders and Parkinson’s disease in particular. He was medical adviser to the Parkinson’s Disease Association and, together with his wife, Frances, a speech therapist, he freely gave his time and expertise to the clinical and pastoral care of patients with Parkinson’s disease throughout the UK and Ireland.

Mark was brought up in Belfast, where his father was professor of mental health at Queen’s University. He was a pupil at the Royal Belfast Academical Institution, better known as “Inst.” Here he flourished academically and musically and was a member of both the City of Belfast and Northern Ireland youth orchestras. It was at orchestra practice that he met his future wife, Frances, who shared his love of the double bass.

Mark studied medicine at Trinity College Dublin. After house jobs in …
A Drosophila Homolog of Cyclase-Associated Proteins Collaborates with the Abl Tyrosine Kinase to Control Midline Axon Pathfinding
Authors: Zachary Wills, Mark Emerson, Jannette Rusch, Jay Bikoff, Buzz Baum, Norbert Perrimon, David Van Vactor
Journal: Neuron (2002)
543. Monitoring Transgene Expression by Radio-Peptide Positron Emission Tomography
Authors: Amiq Gazdhar, Murat Bilici, Erick Ayuni, Thomas Krause, Michal Hofmann, Raplh A. Schmid
Journal: Molecular Therapy (2006)

Background Progress towards Clinical application of gene therapy is hindered by the lack of possibility to image and trace transgene expression. Optical methods using fluorescent gene products or chemiluminesce inducing enzymes are not fully quantitative because of tissue absorption and fluorescence quenching. By using radioactive probes such as positron emitter labelled radiopeptides, a quantitative method for measuring transgene expression would be available. Aim The feasibility of electroporation mediated gene transfer of human somatostatin receptor 2 (hsstr2) in rats and subsequent PET/CT imaging was evaluated. Methods100 μg of Pcik-hSSTR2 plasmid was injected in the forelimb muscle of anesthetised adult male Fischer rats (n=12) followed by in vivo electroporation with 4, 20ms pulses of 200v/cm. Assessment was performed at 24 hrs after gene transfer and repeated at different time points till day 6. 2-5MBq of Ga-68- DOTATOC (0.5nmol DOTATOC peptide) was injected via the penile vein.30 minutes after injection, PET/CT Siemens/ CTI,Erlangen/Knoxville;LSO Biograph16-pico3D High res,4.0mm intrinsic resolution)scans were performed (10min emission). After reconstruction, segmentation, attenuation and scatter correction of the PET/CT, activity accumulations were measured in the right and left fore limb of the rats. Results All the animals showed moderate to high accumulation of radioactivity in the right fore limb. No significant activity accumulation was found in the contralateral muscles. Correct CT anatomical co registration into the forelimb muscle was found for all animals. Relative expression was found to be increased by a factor of 3-8 as correlated to the contralateral activity. Induction of expression increased by a factor of 2-4 at 24hrs and 48hrs after gene transfer. No activity accumulation could be detected in the forelimbs 6 days after gene transfer. Conclusion Expression of hsstr2 as reporter gene may be detected and quantified by PET/CT.
Peripheral Radionuclide Angiography
Authors: Philip Matin
Journal: JAMA (1979)

RADIOISOTOPES have been used for the dynamic visualization of blood flow through vessels and organs since the invention of the scintillation camera in the early 1960s. Known as radionuclide angiography, scintiangiography, and nuclear flow studies, the technique is simple, safe, and relatively inexpensive. However, until recently, it was able to provide only general information about the blood flow to the extremities. Recent improvements in nuclear medicine instrumentation and techniques have permitted major improvements in the ability of radionuclide angiography to image and quantitate peripheral arterial blood flow. This article describes the technique and discusses its use in studying abnormalities such as stenosis and aneurysm of the vessels of the extremities. Because it is noninvasive and relatively inexpensive, radionuclide angioography is ideal for examination of patients both preoperatively and postoperatively. The fact that relative quantitation of blood flow is possible makes serial studies more objective and accurate. The accuracy of radionuclide
Further Perspectives on Concierge Medicine
Authors: Robert A. Swerlick
Journal: Annals of Internal Medicine (2010)

Letters17 August 2010Further Perspectives on Concierge MedicineRobert A. Swerlick, MDRobert A. Swerlick, MDFrom Emory University, Atlanta, Georgia 30322.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-4-201008170-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I want to thank Stillman (1) for his thoughtful article on concierge medicine. However, I believe that his perspective is colored by assumptions and biases that may not be valid. The first assumption is that his role as a physician is to give patients what he or some third party decides they need rather than what the patients want. Although these 2 goals are ideally the same, more often than not, they diverge. It is unfortunate that the present payment system has created bizarre incentives that foster overconsumption of frequently useless and even dangerous medical interventions and ...Reference1. Stillman M. Concierge medicine: a “regular” physician's perspective. Ann Intern Med. 2010;152:391-2. [PMID: 20231570] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Emory University, Atlanta, Georgia 30322.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoConcierge Medicine: A “Regular” Physician's Perspective Michael Stillman Further Perspectives on Concierge Medicine Robert P. Fields Further Perspectives on Concierge Medicine Christine Harter Further Perspectives on Concierge Medicine James Bowers Further Perspectives on Concierge Medicine Harry M. Walen Further Perspectives on Concierge Medicine Marcy Zwelling-Aamot Metrics 17 August 2010Volume 153, Issue 4Page: 274KeywordsConflicts of interestMotivation ePublished: 17 August 2010 Issue Published: 17 August 2010 CopyrightCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
CONGENITAL ANEURYSM OF THE BRAIN
Authors: H. Reid, H. H. Gleave
Journal: BMJ (1931)

AMOEBIC HEPATITIS WITH HAEMATEMESIS [MTHEB,ITISL 445 flexuires of colon, but apart from this no definite evidence of organic disease."The blood count showed: red blood cells 4,500,000 per c.mm., white blood cells 8,000; polvmorphoiluclears 74 per cent., large mononuclears 4 per cent., lymphocytes 20 per cent., eosinophils 2 per cent.; haemoglobin 90 per cent.colour index 1. 1.No abnormal cells were seen.
Faecal bile acid profiles in patients with large bowel cancer in Japan.
Authors: Y Hikasa, N Tanida, T Ohno, T Shimoyama
Journal: Gut (1984)

To study the possible role of bile acids in carcinogenesis of the large bowel faecal bile acid profiles were analysed in detail in 14 patients with large bowel cancer and compared with 14 matched healthy subjects. The total faecal bile acid excretion was lower in the patients (297.3 +/- 402.8 mumol/day) than in the healthy subjects (470.6 +/- 231.1 mumol/day) (p less than 0.01), although the difference became insignificant when these data were expressed as mumol per wet or dry faecal weight. The faecal profiles of individual bile acids and their conjugates were similar in both groups except that 5 beta-chol-3-en-24-oic acid, a bacterial metabolite of sulpholithocholic acid, was found in nine cancer patients (64%) compared with only two healthy subjects (14%) (p less than 0.01). The significance of 5 beta-chol-3-en-24-oic acid in carcinogenesis needs further prospective and experimental studies.
Tumor promoters stimulate hyperplasia of microtubule organizing center and inhibit DNA synthesis in cultured cells.
Authors: R N Mascardo, P Sherline
Journal: Journal of Clinical Investigation (1984)

Chemical tumor promoters induce significant morphologic changes in several cultured cell models. In this article we describe a new effect of two potent, chemically different tumor promoters, 12-O-tetradecanoylphorbol-13-acetate (TPA) and dihydroteleocidin B (DHTB) on cultured human HeLa and melanoma cells. Using immunofluorescence microscopy, we observed that TPA and DHTB induced a dramatic increase in the size (greater than or equal to 3X normal diameter) of the centrosome, a microtubule-organizing center, within 24 h of incubation. In HeLa cells the effect was serum- and dose-dependent, was observed in 76-92% of cells within 72 h of incubation, and was associated with an increase in cytoplasm-nucleus ratio and proliferation of microtubules from the centrosome. The tumor promoters inhibited serum-induced DNA synthesis in both cell lines. Electron microscopy revealed the presence of clumps of microcentriole bodies or fragments adjacent to the intact centriole.