tbuckley/cabot-search huggingface dataset:
Iron Deficiency Anemia Associated with an Error of Iron Metabolism in Two Siblings *
Authors: Nasrollah T. Shahidi, David G. Nathan, Louis K. Diamond
Journal: Journal of Clinical Investigation (1964)

This report describes the clinical and hemato- logical characteristics of two young siblings with chronic hypochromic microcytic anemia and high serum iron concentrations.Further tests have revealed that neither patient suffers from thalas- semia, hemoglobinopathy, or pyridoxine-respon- sive anemia.Subsequent examinations have disclosed an error in iron metabolism in these pa- tients characterized by massive hepatic iron depo- sition and absent stainable bone marrow iron stores.The association of this discrepancy with the chronic hypochromic anemia present in these two siblings is unique and has stimulated a series of special studies concerning their iron metabo- lism.Case Reports 1) A. A., a 12a-year-old boy of French extraction, was born at term weighing 6 pounds 4 ounces.He was first seen in the Children's Hospital Medical Center at *
Optimal preparation for video capsule endoscopy: a prospective, randomized, single-blind study
Authors: S. van Tuyl, H. den Ouden, M. Stolk, E. Kuipers
Journal: Endoscopy (2007)

See also: Commentaire de travail de A. C. van Tuyl et al., pp. 1037Endoscopy 2007; 39(12): 83-83DOI: 10.1055/s-0032-1308885
Regression of rectal adenomas after colectomy and ileorectal anastomosis for familial adenomatous polyposis
Authors: R J Nicholls, R G Springall, P Gallagher
Journal: BMJ (1988)

Safe limits of drinking: patients' viewsThe agreed recommendations for safe limits of alcohol consumption from the Royal Colleges of Psychiatrists, General Practitioners, and Physicians'are less than 14 units a week for women and less than 21 units a week for men.If these guidelines are to be used by primary health care workers to promote healthy lifestyles, they must be accepted by patients.The results of a survey three years ago showed that there was little consensus among a sample of experts on the effects of alcohol about the safe limits of alcohol consumption.4A similar study among general practitioners showed that they gave lower limits of alcohol consumption than the experts.'The present study was designed to ascertain what limits of alcohol consumption were considered safe by patients attending their general practitioners. Subjects, methods, and resultsNine practices were selected, five in London and four in Oxfordshire.Each practice was given 100 questionnaires and asked to arrange for them to be completed by all patients attending for consultation on one week day.The patients were asked to complete the questionnaire while waiting to see the doctors and to hand the completed questionnaire to them.Each patient's alcohol consumption was assessed by a quantity/frequency question with one unit being equivalent to one half pint of beer, one glass of wine or sherry, or a single measure of spirits.Drinking was classified as light (0-10 units/week), moderate (1 1-35), or heavy (-36).The questionnaire included the question: "In your opinion what is a reasonable or sensible limit that men and women should place on the amount they drink each day if they are to avoid damaging their health?"Patients were asked to give separate answers for subjects who drank only beer, lager, or cider (pints/day); only wine, sherry, or vermouth (glasses/day); and only spirits (single measures/day).Separate answers were sought for men and women.Statistical analysis was by the unpaired Student's t test.Altogether 561 questionnaires were completed, 298 in London and 263 in Oxfordshire.There were 187 men and 374 women; around a third were under 35, a third between 35 and 54, and the remainder over 55 years of age.Nearly half the patients thought that two to four units a day were safe.The table summarises the results.For all drinks men gave higher limits of alcohol consumption than women.Heavy drinkers gave higher limits than light drinkers and, with the exception of beer, patients in London gave higher limits than patients in
Preventing Firearm Violence
Authors: Michael Nacol
Journal: Annals of Internal Medicine (1995)

Letters15 November 1995Preventing Firearm ViolenceMichael Nacol, MD, MDMichael Nacol, MD, MDGeorgetown, TX 78628Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-10-199511150-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The College's position paper [1] does not represent the opinion of many College members. Most people would agree that firearm safety, responsible storage of unloaded firearms, and respect for the possible hazards of firearms are reasonable and necessary. However, to say that “regulatory oversight” of guns or ammunitions is desirable misrepresents the need for a safer society. History tells a different story. In Nazi Germany, for example, Hitler instituted a gun registration policy.Has any nation ever benefited from gun control? The College's support of legislative and regulatory measures that would limit the availability of firearms overextends ...REFERENCE1. American College of Physicians. Preventing firearm violence: a public health imperative. Ann Intern Med. 1995; 122:311-3. Google Scholar Author, Article, and Disclosure InformationAffiliations: Georgetown, TX 78628 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1995Volume 123, Issue 10Page: 813-813KeywordsFire safetyFirearm injuries Issue Published: 15 November 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Discrepancy of Echo-Endoscopic Measurements, Which Could Lead to Inaccurate Recording of Levels During Staging of Esophageal Cancer
Authors: P. F. Rice, S. A. Roberts
Journal: Endoscopy (2003)

Endoscopic ultrasound (EUS) is now well established as an important tool in assessing esophageal cancer. We have previously described the role of the Olympus MH-908 blind esophagoprobe in safely and accurately staging patients with esophageal cancer, including those with high-grade stenoses [1]. Accurate assessment of the level of the tumour with reference to the incisor teeth provides useful information to the surgeon and the oncologist. This can be provided by either endoscopic examination or EUS. The purpose of this report is to describe a discrepancy in these levels, particularly regarding the blind esophagoprobe (MH-908).
Factor XI Deficiency in Ashkenazi Jews in Israel
Authors: Rei Asakai, Dominic W. Chung, Earl W. Davie, Uri Seligsohn
Journal: New England Journal of Medicine (1991)

Severe factor XI deficiency, which is relatively common among Ashkenazi Jews, is associated with injury-related bleeding of considerable severity. Three point mutations--a splice-junction abnormality (Type I), Glu117----Stop (Type II), and Phe283----Leu (Type III)--have been described in six patients with factor XI deficiency. Clinical correlations with these mutations have not been carried out. We determined the relative frequency of the mutations and their association with plasma levels of factor XI clotting activity and bleeding, analyzing the mutations with the polymerase chain reaction and restriction-enzyme digestion.The Type II and Type III mutations had similar frequencies among 43 Ashkenazi Jewish probands with severe factor XI deficiency; these two mutations accounted for 49 percent and 47 percent, respectively, of a total of 86 analyzed alleles. Among 40 of the probands and 12 of their relatives with severe factor XI deficiency, patients homozygous for Type III mutation had a significantly higher level of factor XI clotting activity (mean [+/- SD] percentage of normal values, 9.7 +/- 3.8 percent; n = 13) than those homozygous for Type II mutation (1.2 +/- 0.5 percent, n = 16) or compound heterozygotes with Type II/III mutation (3.3 +/- 1.6 percent, n = 23), as well as significantly fewer episodes of injury-related bleeding. Each of these three groups had a similarly increased proportion of episodes of bleeding complications after surgery at sites with enhanced local fibrinolysis, such as the urinary tract, or during tooth extraction.Type II and Type III mutations are the predominant causes of factor XI deficiency among Ashkenazi Jews. Genotypic analysis, assay for factor XI, and consideration of the type and location of surgery can be helpful in planning operations in patients with this disorder.
Quantification of Heterogeneity on 201Tl Gated SPECT
Authors: Yasuhiro Maruoka, Michinobu Nagao, Koichiro Abe, Shingo Baba, Takuro Isoda, Taiki Higo, Kenji Sunagawa, Hiroshi Honda
Journal: Clinical Nuclear Medicine (2012)

The purpose of this study was to propose a new index that quantifies the heterogeneity of myocardial uptake on gated myocardial perfusion SPECT (GMPS) with ²⁰¹Tl and investigate its utility in diagnosing multivessel coronary artery disease (CAD).In 51 patients with CAD, adenosine-stress ²⁰¹Tl GMPS and coronary angiography (CAG) were performed. On the basis of the American Heart Association's 17-segment model, segmental percentage uptake on stress, and redistribution images of GMPS were measured at end-systole and end-diastole. The coefficient of variance (CV) of 17 segmental percentage uptake for each patient was used as an estimate of the heterogeneity of myocardial uptake. According to the results of CAG, patients were divided into insignificant coronary artery stenosis (insignificant-CAD), single-vessel CAD, and multivessel CAD groups. The differences in CV among the 3 groups were analyzed by 1-way analysis of variance and Tukey-Kramer test. The diagnostic capability for multivessel CAD was analyzed using the receiver operating characteristics (ROC) curve analysis.Stress end-diastolic CV for patients with multivessel CAD [mean (SD), 18.1% (3.5%)] was significantly greater than that for single-vessel CAD [12.8% (2.9%), P<0.0001] and insignificant-CAD [10.1% (0.9%), P<0.0001]. Stress end-systolic CV for patients with multivessel CAD [23.4% (5.2%)] was significantly greater than that for insignificant-CAD [16.5% (4.1%), P=0.002], whereas there was no difference between single-vessel [20.9% (6.1%)] and multivessel CAD. Using an optimal cutoff of stress end-diastolic CV diagnosed multivessel CAD with a sensitivity of 84%, a specificity of 92%, an accuracy of 88%, and an area under the curve of 0.89.The heterogeneity of myocardial percentage uptake on ²⁰¹Tl GMPS was correlated with the severity of CAD. Stress end-diastolic CV value is a candidate index for differentiating patients with multivessel CAD from single-vessel CAD and insignificant-CAD.
Electrocardiographic Left Ventricular Hypertrophy and Risk of Coronary Heart Disease
Authors: WILLIAM B. KANNEL
Journal: Annals of Internal Medicine (1970)

Risk of clinically overt coronary heart disease in 190 persons with "definite" and 264 with "possible" electrocardiographic left ventricular hypertrophy (ECG-LVH) was compared with that of a total cohort of 5,127 men and women followed over 14 years. Prevalence of both coronary heart disease and ECG-LVH increased in proportion to antecedent blood pressure. Persons who acquired "definite" ECG-LVH had a residual threefold increased risk of clinically overt coronary heart disease after adjustment for the effect of coexisting hypertension. "Possible" ECG-LVH was associated with a twofold increased risk, but this was virtually obliterated on adjustment for hypertension. Risk of every clinical manifestation of coronary heart disease, and of death in particular, was increased, and 40% with prior ECG-LVH died in their initial attack, a fatality rate comparable with that of persons with prior overt coronary heart disease. ECG-LVH is thus a grave prognostic sign and a harbinger of clinically overt coronary heart disease. It is tempting to hypothesize that ECG-LVH without other explanation based mainly on increased voltage (possible LVH) is largely an expression of hypertensive hypertrophy and that with more marked voltage increases accompanied by S-T and T wave abnormality (definite LVH) indicates ischemic myocardial involvement.
Malaria in Servicemen from Vietnam
Authors: THOMAS W. SHEEHY
Journal: Annals of Internal Medicine (1967)

Editorial Notes1 February 1967Malaria in Servicemen from VietnamTHOMAS W. SHEEHYTHOMAS W. SHEEHYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-2-447 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBetween January 1 and November 30, 1966, 390 cases of malaria were reported in the United States. Three hundred twelve of these infections were in military personnel and 92% of these individuals incurred their infections in Vietnam (1). Forty percent of the military patients with malaria were seen initially by civilian physicians. Troops returning from Vietnam are brought home by jet aircraft, and it is not unusual for returnees to be in a civilian community 3 to 4 days after their departure from Saigon. This policy, the large number of troops rotating from Vietnam (about 250,000 in 1966), and the...References1. LOBEL HO: Personal communication. Google Scholar2. INMAN M: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySulphadoxine and pyrimethamine as treatment for acute Plasmodium falciparum malariaThe narcotic addict as a medical patientPathophysiology of acute falciparum malaria 1 February 1967Volume 66, Issue 2Page: 447-447KeywordsArmed forcesMalaria Issue Published: 1 February 1967 PDF DownloadLoading ...
Who'd be a reformer?
Authors: J. Shepherd
Journal: BMJ (2003)

Ten years ago I was not prepared for the critical letter from the president of my surgical association, after the publication of a BMJ editorial I had jointly written (1994;309: 620-1) on surgical removal of third molars–one of the commonest operations. We said, on the basis of convincing evidence, that prophylactic removal should be abandoned. I had, apparently, been naive. He was certainly right in one respect: I had been naive enough to think that our conclusion–later reached by the National Institute for Clinical Excellence in its first technology appraisal–would, in the age of evidence based medicine, be welcomed.

The ensuing debate in the BMJ 's letters pages was polarised by the media. A Times article starkly contrasted our conclusion with the opposite view of a consultant colleague in my own department. The headline in the Independent on Sunday , “Millions wasted on wisdom teeth,” spanned a whole page. This taught me something else: that professional and public controversy can …
POST-GRADUATE TRAINING IN THE PRACTICE OF PREVENTIVE MEDICINE IN INDUSTRY
Authors: G. P. Crowden
Journal: BMJ (1936)

ME BRTTTSD R IA -~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~MDCLJIRA adhesive meningitis, leads to distension of the third ventricle.The distended cyst-like third ventricle may act as a tumour in exercising injurious pressure upon the surrounding hypothalamic centres, the optic chiasma, the bony structure of the sella turcica, and the pituitary gland itself.Thus hydrocephalus secondary to disease elsewhere may give rise to Frohlich's syndrome, to bitemporal hemianopia, to stunting of growth, and to erosion of the sella turcica recognizable in x-ray studies.(To be continued)
Apparent Anaphylaxis from Labetalol
Authors: CHARLES E. FERREE
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 May 1986Apparent Anaphylaxis from LabetalolCHARLES E. FERREE, M.D.CHARLES E. FERREE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-5-729_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: An anaphylactoid reaction to oral Normodyne (labetalol; Schering Corporation, Kenilworth, New Jersey) has not been reported previously. Labetalol is an adrenergic-receptor-blocking agent that has both selective alpha-1- and nonselective beta-adrenergic-blocking actions; it is presently marketed for the management of hypertension. As with other drugs with beta-blocking activity, labetalol has been reported to cause nonallergic bronchospasm, particularly in patients with preexisting bronchospastic diseases, as well as other adverse effects common to many antihypertensive agents (1). I report the case of a patient who had acute onset of urticaria, angioedema, and hypotension after a single dose of Normodyne.A...References1. TCHERDAKOFF P. Side-effects with long-term labetalol: an open study of 251 patients in a single centre. Pharmatherapeutica. 1983;3:342-8. MedlineGoogle Scholar2. BROWNCOOKELOSOWSKY RJM. SLE syndrome, probably induced by labetalol. Postgrad Med J. 1981;57:189-90. CrossrefMedlineGoogle Scholar3. STAUGHTONSUTTONFARRELL RRM. Beta-blockers, autoimmunity, and rashes [Letter]. Lancet. 1980;2:581. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Mecklenburg Medical Group Charlotte, NC 28211 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByConjonctivite et œdème des paupières par allergie de contact à quatre bêta-bloquants utilisés en collyresContact anaphylactoid response to labetalol 1 May 1986Volume 104, Issue 5Page: 729-730KeywordsAnaphylaxisDrugsHypertensionHypotensionUrticaria Issue Published: 1 May 1986 PDF DownloadLoading ...
Regulation of human lung fibroblast glycosaminoglycan production by recombinant interferons, tumor necrosis factor, and lymphotoxin.
Authors: J A Elias, R C Krol, B Freundlich, P M Sampson
Journal: Journal of Clinical Investigation (1988)

Mononuclear cells may be important regulators of fibroblast glycosaminoglycan (GAG) biosynthesis. However, the soluble factors mediating these effects, the importance of intercytokine interactions in this regulation and the mechanisms of these alterations remain poorly understood. We analyzed the effect of recombinant (r) tumor necrosis factor (TNF), lymphotoxin (LT), and gamma, alpha, and beta 1 interferons (INF-gamma, -alpha and -beta 1), alone and in combination, on GAG production by normal human lung fibroblasts. rTNF, rLT, and rINF-gamma each stimulated fibroblast GAG production. In addition, rIFN-gamma synergized with rTNF and rLT to further augment GAG biosynthesis. In contrast, IFN-alpha A, -alpha D, and -beta 1 neither stimulated fibroblast GAG production nor interacted with rTNF or rLT to regulate GAG biosynthesis. The effects of the stimulatory cytokines and cytokine combinations were dose dependent and were abrogated by the respective monoclonal antibodies. In addition, these cytokines did not cause an alteration in the distribution of GAG between the fibroblast cell layer and supernatant. However, the stimulation was at least partially specific for particular GAG moieties with hyaluronic acid biosynthesis being markedly augmented without a comparable increase in the production of sulfated GAGs. Fibroblast prostaglandin production did not mediate these alterations since indomethacin did not decrease the stimulatory effects of the cytokines. In contrast, protein and mRNA synthesis appeared to play a role since the stimulatory effects of the cytokines were abrogated by cyclohexamide and actinomycin D, respectively. In addition, the cytokines and cytokine combinations increased cellular hyaluronate synthetase activity in proportion to their effects on hyaluronic acid suggesting that induction of this enzyme(s) is important in this stimulatory process. These studies demonstrate that IFN-gamma, TNF, and LT are important stimulators of fibroblast GAG biosynthesis, that interactions between these cytokines may be important in this regulatory process, that these cytokines predominantly stimulate hyaluronic acid production and that this effect may be mediated by stimulation of fibroblast hyaluronate synthetase activity.
THE HUMAN TOE NAIL. ITS GENESIS AND BLOOD SUPPLY.
Authors: PETER D. SAMMAN
Journal: British Journal of Dermatology (1959)

Journal Article THE HUMAN TOE NAIL. ITS GENESIS AND BLOOD SUPPLY. Get access PETER D. SAMMAN, M.D., M.R.C.P. PETER D. SAMMAN, M.D., M.R.C.P. Assistant Physician, Dermatological Department, Westminster Hospital, London, S.W.I.* Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 71, Issue 8-9, 1 August 1959, Pages 296–302, https://doi.org/10.1111/j.1365-2133.1959.tb13427.x Published: 01 August 1959
1138-64 Major reduction in adverse outcomes of patients with congestive heart failure undergoing percutaneous coronary intervention: A comparison of the National Heart, Lung, and Blood Institute 1985–1986 percutaneous transluminal coronary angioplasty registry and the current dynamic registry
Authors: Elizabeth M Holper, David P Faxon, Alice K Jacobs, David O Williams, Paul Coady, Faith Selzer, Helen Vlachos, Katherine M Detre
Journal: Journal of the American College of Cardiology (2004)
Phase I-II Trial of Erythropoietin in the Treatment of Cisplatin-Associated Anemia
Authors: C. B. Miller, L. C. Platanias, S. R. Mills, M. L. Zahurak, M. J. Ratain, D. S. Ettinger, R. J. Jones
Journal: JNCI Journal of the National Cancer Institute (1992)

Cancer patients undergoing chemotherapy with cisplatin-containing regimens often develop anemia. Although the cause is multifactorial, erythropoietin deficiency appears to play an important role. Recombinant human erythropoietin (epoetin) has been reported to be effective in reversing cisplatin-associated anemia in animal studies but not in clinical trials.This pahse I-II clinical trial was designed to assess the safety and efficacy of treatment with epoetin for anemia associated with cisplatin chemotherapy.Twenty-one cancer patients treated with cisplatin and manifesting anemia (hemoglobin level less than 110 g/L) received epoetin at escalating doses (25, 50, 100, or 200 U/kg body weight) intravenously five times a week for 4 weeks.Epoetin was well tolerated, and a maximal tolerated dose was not reached. Two patients experienced hypertension, which responded to standard antihypertensive therapy. No dose-dependent severe toxic effects were seen. The increase in hemoglobin levels from baseline on day 1 of the study was statistically significant after 4 weeks of epoetin therapy in the groups receiving 100 U/kg (mean change +/- SD = 19 +/- 13 g/L; P = .03) or 200 U/kg (mean change = 24 +/- 17 g/L; P = .007). A clinical response--an increase in hemoglobin level greater than 10 g/L--was achieved in 12 patients after 4 weeks of treatment. For these responders, the mean increase in hemoglobin level was 25 +/- 3.3 g/L over the level observed at the same time in the chemotherapy cycle preceding epoetin treatment, and this increase was statistically significant (P = .0001). Neither serum erythropoietin level nor hemoglobin level predicted a patient's response to epoetin.These preliminary findings suggest that epoetin is effective and well tolerated for the reversal of cisplatin-associated anemia, with the 100-U/kg and 200-U/kg dose levels offering optimal clinical response.We are conducting a phase III trial to determine the effect of epoetin on transfusion requirements in patients undergoing chemotherapy.