tbuckley/cabot-search huggingface dataset:
Role of Endogenous Bradykinin in Human Coronary Vasomotor Control
Authors: Peter Groves, Sabine Kurz, Hanjörg Just, Helmut Drexler
Journal: Circulation (1995)

Background Bradykinin is a potent vasodilator that acts through B 2 kinin receptors to stimulate the release of endothelium-derived nitric oxide, prostacyclin, and hyperpolarizing factor. In this study, we investigated the contribution of endogenous bradykinin to vasomotor control in the human coronary circulation. Methods and Results The selective bradykinin B 2 receptor antagonist HOE 140 was infused into the left main coronary artery (200 μg/min for 15 minutes) in 15 patients without significant coronary stenoses. Epicardial responses were evaluated by quantitative coronary blood flow with a Doppler flow-velocity wire. Flow-dependent dilation (n=10; intracoronary papaverine) and acetylcholine responses (n=5) were assessed before and after HOE 140. After HOE 140, there was a reduction in luminal area in the proximal ( P &lt;.001), mid ( P &lt;.001), and distal ( P &lt;.05) coronary arteries. HOE 140 led to an increase in coronary vascular resistance ( P &lt;.001) and a decrease in coronary blood flow ( P &lt;.001). After bradykinin B 2 receptor blockade, there was a reduction in flow-dependent dilation (23.4±6.9% to 3.9±6.0%, P &lt;.001), the extent of which correlated with the degree of basal vasoconstriction after HOE 140 in the same vessel segment ( P &lt;.05). Acetylcholine responses were unchanged after HOE 140. Conclusions The results of this study demonstrate for the first time a role for endogenous bradykinin in mediating normal vasomotor responses in resistance and epicardial coronary vessels under basal and flow-stimulated conditions in the human coronary circulation.
LIFE AND TIMES OF DOCTOR REUBEN D. MUSSEY.
Authors: JOHN B. HAMILTON
Journal: JAMA (1896)

<h3>Mr. President, Ladies and Gentlemen:</h3> —I thank you for this gracious reception and your kindly words of introduction. But I do not feel like a stranger in this great State of Ohio. My great-grandfather, a Revolutionary soldier, settled at Point Harmar, subsequently helped defend the Territory against the Indians, and was a member of the Second Legislative Assembly of this State. My mother was born on the beautiful banks of the lower Muskingum, and my grandmother on my father's side was the daughter of Captain Benjamin Brown, one of the earliest settlers of Athens County, and whose numerous descendants still inhabit the Ohio River Valley. Therefore, in speaking in this famous Capitol, to this distinguished audience, I feel that I have a closer personal interest in this people than my friend Dr. Reed was aware of when he asked me to address you on this occasion.
Radiological findings in seropositive juvenile chronic arthritis (juvenile rheumatoid arthritis) with particular reference to progression.
Authors: R A Williams, B M Ansell
Journal: Annals of the Rheumatic Diseases (1985)

The radiological effects of peripheral joint disease in 81 patients with seropositive juvenile chronic arthritis were studied retrospectively with an average length of follow up of 11 years. The patients comprised 63 girls and 18 boys with average ages of onset being 10.7 years and 12.1 years respectively. All had developed positive serology within the first year of the disease. X-rays available in 70 of these patients at five years from onset of the disease showed erosive change to be present in all but three. The sites most commonly affected included the carpus, the metacarpal, the metatarsal, and interphalangeal joints, though a third of the patients also showed erosive change in large joints such as hips, knees, or shoulders. Between five and 10 years after disease onset progression of x-ray changes was evident in most patients, with additional joints becoming involved in about one third, though the distribution of joints was similar. After 15 years or more of disease the radiological changes tended to be more stable, but various mechanical difficulties often secondary to poor growth and degenerative change and to primary destructive inflammatory arthritis were evident. No specific drug regimen was found to have been universally effective in suppressing disease, and the frequency of side effects was a significant factor in preventing treatment schedules being maintained for long enough to be effective.
Evaluation of left coronary artery anatomy in vitro by cross-sectional echocardiography.
Authors: E W Rogers, H Feigenbaum, A E Weyman, R W Godley, S T Vakili
Journal: Circulation (1980)

This study was undertaken to provide a better anatomic description of the location and course of the left coronary artery within a commonly used ultrasonic tomographic plane. Twenty-three hearts were excised at autopsy and scanned in vitro. The locations of the left main (LMCA), left anterior descending (LAD), and left circumflex (LCCA) coronary arteries were confirmed by direct cannulation, by Cardio-Green injection, and by subsequent dissection. While the proximal LMCA was recorded in all specimens, the entire LMCA was visible in only 70%. Proximal portions of the LAD and LCCA were also identifiable in 70% of examinations, and their spatial positions were defined. In most recordings, the first branch of the LAD OR LCCA arose distal to the segment seen echocardiographically. The spatial orientation of the ultrasonic beam relative to the LAD and LCCA and the presence of other overlying cardiac structures limit the imaging of these vessels by cross-sectional echocardiography to only their most proximal portions.
Class-specific antibodies in young and aged humans against organisms producing superficial fungal infections
Authors: P.G. SOHNLE, C. COLLINS-LECH, K.E. HUHTA
Journal: British Journal of Dermatology (1983)

Journal Article Class‐specific antibodies in young and aged humans against organisms producing superficial fungal infections Get access P.G. SOHNLE, P.G. SOHNLE Department of Medicine, The Medical College of Wisconsin, Milwaukee, and the Medical and Research Services, Veterans Administration Medical Center, Wood (Milwaukee), Wisconsin, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar C. COLLINS‐LECH, C. COLLINS‐LECH Department of Medicine, The Medical College of Wisconsin, Milwaukee, and the Medical and Research Services, Veterans Administration Medical Center, Wood (Milwaukee), Wisconsin, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar K.E. HUHTA K.E. HUHTA Department of Medicine, The Medical College of Wisconsin, Milwaukee, and the Medical and Research Services, Veterans Administration Medical Center, Wood (Milwaukee), Wisconsin, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 108, Issue 1, 1 January 1983, Pages 69–76, https://doi.org/10.1111/j.1365-2133.1983.tb04580.x Published: 01 January 1983 Article history Accepted: 18 May 1982 Published: 01 January 1983
Sexually Transmitted Diseases: Women as Victims
Authors: William M. McCormack
Journal: JAMA (1982)

Sexually transmitted diseases have once again become an area of medical interest. In the era before antibiotics, these diseases, primarily syphilis, attracted the attention and the efforts of the best clinical and academic minds. The availability of penicillin, with its almost miraculous efficacy against syphilis and gonorrhea, led to the general belief that all of the problems of sexually transmitted diseases had been solved. The clinicians and investigators of the day turned their attention to more pressing problems. An entire generation of physicians—those who began their careers between 1950 and 1970—ignored the sexually transmitted conditions. Although this era corresponded with a spectacular growth in academic medicine, virtually none of the new investigators chose sexually transmitted diseases as their area of concentration. It was not until about 1970 that sexually transmitted diseases began to attract some attention, due mainly to a dramatic increase in the number of cases of gonorrhea. The
Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis.
Authors: P J Shultz, L Raij
Journal: Journal of Clinical Investigation (1992)

Escherichia coli endotoxin (LPS) can induce the clinical syndrome of septic shock and renal cortical necrosis and can stimulate nitric oxide (NO) production from macrophages, vascular smooth muscle, and glomerular mesangial cells in vitro. NO is an endogenous vasodilator, which also inhibits platelet aggregation and adhesion. We therefore sought to determine whether LPS would stimulate NO production in vivo and, if so, whether this NO would modulate endotoxin-induced glomerular thrombosis. The stable NO end-products, NO2 and NO3, were measured in serum and urine collections from rats during baseline and after injection of LPS, with or without substances that modulate NO synthesis. The urinary excretion of NO2/NO3 was 1,964 +/- 311 nm/8 h during the baseline and increased to 6,833 +/- 776 nm/8 h after a single intraperitoneal injection of 0.1 mg/kg LPS (P < 0.05). The serum concentration of NO2/NO3 also significantly increased after LPS injection. Both the urine and serum stimulation was significantly prevented by the NO synthesis inhibitor, Nw-nitro-L-arginine methyl ester (L-NAME). L-Arginine, given with LPS+L-NAME significantly restored the NO2/NO3 levels in the urine. Ex vivo incubation of tissues from rats treated with LPS demonstrated NO production by the aorta, whole kidney, and glomeruli, but not cortical tubules. Histological examination of kidneys from rats given either LPS or L-NAME alone revealed that 2 and 4.5% of the glomeruli contained capillary thrombosis, respectively. In contrast, rats given LPS+L-NAME developed thrombosis in 55% of glomeruli (P < 0.001), which was significantly prevented when L-arginine was given concomitantly. We conclude that LPS stimulates endogenous production of NO in vivo and that this NO is critical in preventing LPS-induced renal thrombosis.
Cephalosporin‐induced immune cytopenia in the dog: Demonstration of erythrocyte‐, neutrophil‐, and platelet‐associated igg following treatment with cefazedone
Authors: John C. Bloom, Patricia A. Thiem, Teresa S. Sellers, Hugh B. Lewis, Ahmed Deldar
Journal: American Journal of Hematology (1988)

Cephalosporin treatment in man has been associated with a low incidence of hemolytic anemia, thrombocytopenia, and neutropenia; some cases have been shown to be immune-mediated. This triad of blood dyscrasias was also demonstrated in our laboratory in a series of toxicity studies in dogs of two cephalosporin compounds, cefonicid and cefazedone; these studies provided evidence for drug-associated immune hemolytic anemia, based on conventional laboratory tests. To further investigate possible immune mechanisms of the cephalosporin-induced cytopenias, we measured erythrocyte-associated, platelet-associated (PAIgG), and serum antineutrophil IgG over the course of cephalosporin treatment, using highly sensitive 125I-staphylococcal protein A (SPA) assays, as well as the direct antiglobulin test; we compared these findings with the hematologic changes. Intravenous treatment with high doses of cefazedone (540 mg/kg/day, increased to a maximum of 840 mg/kg/day for 4 months or until hematologic effects were evident) resulted in a high incidence of anemia (7/14), thrombocytopenia (11/14), and neutropenia (7/14). Of the affected dogs examined, 6/7 with anemia, 9/9 with thrombocytopenia, and 7/7 with neutropenia showed increased levels of the respective cell-associated antibody, compared with untreated controls. Unaffected dosed animals generally did not show these changes. In 3/3 dogs examined following remission of thrombocytopenia, PAIgG returned to levels comparable with controls; as one of these dogs suffered a relapse, increased PAIgG was again observed. Animals sacrificed during cytopenic episodes showed cytologic and histologic evidence of increased hemophagocytosis. We conclude that antibody-mediated blood cell destruction contributes to all three cephalosporin-induced cytopenias in the dog.
BACTERIOSTATIC AND LYTIC ACTIONS OF PENICILLIN ON SENSITIVE AND RESISTANT STAPHYLOCOCCI 1
Authors: William M. M. Kirby
Journal: Journal of Clinical Investigation (1945)

In contrast to other bacteria, staphylococci undergo lysis when allowed to multiply in the presence of bacteriostatic concentrations of penicillin.As noted previously (1), all peni- cillin sensitive strains are lysed, whereas insensi- tive strains resist this lytic action.The follow- ing observations clarify certain fundamental aspects of both lysis and bacteriostasis, and have important clinical as well as theoretical im- plications. EXPERIMENTALThe general methods have been described in detail elsewhere (1).For the present study, large inocula (10 to 50 million organisms per ml.) of 100 penicillin-sensitive strains of Staph.aureus (coagulase positive), isolated from patients with furuncles, abscesses, or osteomyelitis, were
THE GENERAL MANAGEMENT OF RHEUMATOID ARTHRITIS
Authors: CHARLES RAGAN
Journal: JAMA (1949)

What is described as rheumatoid arthritis may represent more than one disease. The onset is variable, the course is characterized by remissions and exacerbations, and it is impossible to forecast the future course of events in the individual patient. Diagnosis is difficult in early cases, and an exact prognosis may be difficult even in cases of long duration.  This paper will concern itself solely with rheumatoid arthritis of the peripheral joints. Rheumatoid, or Marie-Strumpell, spondylitis will not be discussed, because it is apparently a different disease and in our opinion should not be classified as rheumatoid arthritis. The reasons for this exclusion are several. The sex distribution is entirely different. In rheumatoid spondylitis 80 per cent of the patients are men, but in rheumatoid arthritis only 23 per cent are men. The agglutination of group A hemolytic streptococci is positive in 50 per cent of patients with rheumatoid arthritis,but
10<sup>6</sup> depletion of WBC with CF‐2, a new leukocyte removal filter
Authors: Yoshihiro Endo, Tohru Tani, Tohru Yokota, Yoshihiro Tsutamoto, Masashi Kodama
Journal: American Journal of Hematology (1993)

A new leukocyte removal filter, Nipro CF-2, was evaluated. A non-woven polyester filter, gravity flow device that does not require priming and rinsing after use was developed to remove white blood cells from 400 ml of whole blood or concentrates of 400 ml of whole blood. A flow cytometric technique was developed to measure extremely low WBC counts. To evaluate the efficiency of this filter, leukocyte counts were measured by flow cytometry using a Coulter EPIC-C cytometer. After filtration through a CF-2 filter, more than 99.9999% of WBCs were depleted from 6 of 17 samples. The mean value of WBC depletion was 99.9994%. The CF-2 filter achieved nearly a million-fold depletion of WBCs from whole blood concentrates.
Resolution of Recurrent Focal Segmental Glomerulosclerosis after Retransplantation
Authors: Lorenzo Gallon, Joseph Leventhal, Anton Skaro, Yashpal Kanwar, Antonio Alvarado
Journal: New England Journal of Medicine (2012)

The authors of this letter describe the successful retransplantation of an allograft that was failing in its first recipient owing to recurrent primary focal segmental glomerulosclerosis. In the second recipient, all evidence of the nephrotic syndrome resolved.
National Trends of Research in Psychology and Psychiatry (1981-1995)
Authors: Giovanni A. Fava, Antonella Montanari
Journal: Psychotherapy and Psychosomatics (1997)

Editorials| February 18 2010 National Trends of Research in Psychology and Psychiatry (1981-1995) Subject Area: Psychiatry and Psychology Giovanni A. Fava; Giovanni A. Fava Bologna, Italy Search for other works by this author on: This Site PubMed Google Scholar Antonella Montanari Antonella Montanari Bologna, Italy Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1997) 66 (4): 169–174. https://doi.org/10.1159/000289130 Article history Published Online: February 18 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Giovanni A. Fava, Antonella Montanari; National Trends of Research in Psychology and Psychiatry (1981-1995). Psychother Psychosom 1 April 1997; 66 (4): 169–174. https://doi.org/10.1159/000289130 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1997Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Educating Physicians in Home Health Care
Authors: William F. Keenan
Journal: JAMA (1991)

<h3>To the Editor.—</h3> The Council on Scientific Affairs' article<sup>1</sup>on the education of physicians in home health care struck home. I recently left a private practice, in which we made a significant number of house calls, to take a faculty position. Although there were many factors in my decision, one important factor was the poor reimbursement our practice received for many of our services, including house calls, and the nonexistent reimbursement for the management of home health care. Poor reimbursement is mentioned in the article, but I feel this point needs to be strongly emphasized. Family physicians make a large number of house calls in this country and treat many housebound patients. Reimbursement rates for house calls are often ridiculously low. In my experience, even this low reimbursement was often denied because visits were often deemed "medically unnecessary" by unpublished criteria. Fighting for reimbursement, when successful, was usually not
Cutaneous metastasis from a presumed signet-ring cell carcinoma in a 10-year-old child
Authors: None Alonso-Llamazares, None DE Pablo, None BallestIN, None Guerra, None Iglesias
Journal: British Journal of Dermatology (1998)

Cutaneous metastases of internal malignancies are very rare in children. In this group, neuroblastoma, leukaemia and lymphoma are the most common malignancies that may develop metastases or neoplastic infiltrates to the skin. Carcinomas have infrequently been reported in children, and cutaneous metastases from carcinoma in this group have not been described. A 10‐year‐old girl presented with an erythematous plaque on the left hemithorax. Histopathological findings revealed grouped signet‐ring cells within the lumina of lymphatic vessels in the dermis. Immunohistochemical examination confirmed the epithelial origin of the tumour. Despite an exhaustive search, the primary site could not be determined. This exceptional observation is, to the best of our knowledge, the first report of cutaneous metastasis from occult carcinoma in a child.
Patient-Funded Cancer Research
Authors: Robert K. Oldham
Journal: New England Journal of Medicine (1987)

The introduction of a new medical treatment into clinical oncology has historically involved an institutional approach to drug development. Over the past 30 years, more than 500,000 compounds have been examined for anticancer activity; about 40 drugs (10 of which are moderately to highly effective) are now in clinical use.The development of anticancer drugs has involved institutions such as the National Cancer Institute (NCI), the pharmaceutical industry, and major university research centers. On average, the process has taken 10 years and $60 million to $90 million per drug. As founder and former director of the Biological Response Modifiers Program . . .
Most of world's refugees are hosted by poor countries, shows report
Authors: P. Moszynski
Journal: BMJ (2011)

Many of the world’s poorest countries are hosting huge populations of refugees, both in absolute numbers and in relation to the size of their economies, says a new report released this week by the United Nations Office of the High Commissioner for Refugees (UNHCR).

The agency says that the report reveals “a deep imbalance in international support for the world’s forcibly displaced, with a full four-fifths of the world’s refugees being hosted by developing countries—and at a time of rising anti-refugee sentiment in many industrialised ones.”

The report points out that most refugees flee to neighbouring countries. “Contrary to common belief, the …
Confessions of a Disease Monger
Authors: James Phelps
Journal: PLoS Medicine (2006)

I am a disease monger.I teach primary care doctors how to identify bipolar disorder.Worse yet, I take money from pharmaceutical companies for doing so.I use it to subsidize my practice so that I can treat patients with no insurance, or little money, who now account for over a third of my patients-in part because the pharmaceutical companies have drained so much money out of the health-care system.Ironic, isn't it?My Web site PsychEducation.org(http:⁄⁄www.psycheducation.org) is number one on Google for searches on "bipolar II."See if you think it looks like disease mongering.Hundreds of people have written thanking me for explaining bipolar II and the concept of a bipolar spectrum, indicating that this new perspective really helps them understand their long-standing symptoms.To my immediate recall, none have complained about being led astray by an overbroad interpretation of bipolarity.Notice that, just like Mr. Moynihan, one of the guest editors of your April 2006 series of articles on disease mongering [1], I could be mongering even now, as I too have a new book.At least I'm not trying to attract attendees to my conference.Tricky, isn't it.Has there been an oversimplifi cation in this analysis?(PsychEducation.org