tbuckley/cabot-search huggingface dataset:
Alexithymia in Inflammatory Bowel Disease
Authors: Piero Porcelli, Simona Zaka, Claudio Leoci, Sandro Centonze, Graeme J. Taylor
Journal: Psychotherapy and Psychosomatics (1995)

The purported association between alexithymia and inflammatory bowel disease (IBD) was investigated in a group of 112 IBD patients (89 with ulcerative colitis and 23 with Crohn's disease) using the well-validated 20-Item Toronto Alexithymia Scale. Alexithymia was assessed also in a group of 112 normal subjects matched for gender, age, and education. The IBD group was significantly more alexithymic than the control group, and no significant difference was found between the ulcerative colitis and Crohn's disease patients. Alexithymia was unrelated to the duration of illness and the level of disease activity. Although the rate of alexithymia in the IBD group (35.7%) was significantly higher than the rate in the control group (4.5%), it is lower than rates of alexithymia that have been found among psychiatric patients with disorders that also have been linked theoretically and clinically with alexithymia.
Monitoring the T Cell Response in a Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) to Phenytoin in both Peripheral Blood and Skin
Authors: J.A. Cornejo-Garcia, E. Martin, T.D. Fernandez, C. Mayorga, S. Lopez, R. R-Pena, I. Doña, J.L. Rodriguez-Bada, M. Blanca;
Journal: Journal of Allergy and Clinical Immunology (2006)
Pulmonary Metastasis of Struma Ovarii
Authors: Isabelle Faugeron Ruel, Hélène Fierrard, Laetitia Vercellino, Laurence Bernard, Elif Hindie, Françoise Duron, Marie Elisabeth Toubert
Journal: Clinical Nuclear Medicine (2010)

We report the case of a 42-year-old woman who presented with multiple pulmonary nodules. Surgical resection of 3 nodules revealed differentiated thyroid carcinoma. Thyroid and neck ultrasound was normal. A review of her history revealed that this patient underwent an ovarian cyst resection 15 years ago. Reexamination of pathology samples, with the help of immunohistochemical markers, concluded to a struma ovarii. Pelvic ultrasound was normal; F-18 FDG PET scan was negative. She had total thyroidectomy, with negative histology, followed by first I-131 therapy (3.9 GBq). Thyroglobuline (Tg) was elevated (3230 μg/L in hypothyroidism). The whole-body scan showed multiple foci of pulmonary I-131 uptake, a bone metastasis of third rib, and I-131 uptake in an abdominal para-aortic lymph node. At second I-131 therapy (3.8 GBq), Tg level had decreased to 14 μg/L and there was a decrease in the number of pulmonary nodular I-131 uptake, and resolution of the bone and para-aortic lymph node metastasis. At third I-131 therapy (4.9 GBq), thyroglobuline was undetectable and the whole-body scan showed no I-131 uptake. Struma ovarii is a rare ovarian tumor mostly benign. Metastasis of malignant struma ovarii are rare. Most frequent localizations are liver and peritoneum. Treatment of the malignant struma ovarii implies ovarian surgical resection, total thyroidectomy, and I-131 therapy.
Complementary Health Practices—Reply
Authors: Paul Offit
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiovascular effects of training for a marathon run
Authors: L O Simpson
Journal: BMJ (1987)

<h3>Abstract</h3> Sleep plays a critical role in memory consolidation, however, the exact role that sleep and its effects on neural network dynamics play in this process is still unclear. Here, we combine computational and experimental approaches to study the dynamical, network-wide underpinnings of hippocampal memory consolidation during sleep. We provide data to support a novel hypothesis on the role of cellular resonance with sleep-associated theta band (4-12 Hz) hippocampal oscillations in this process. We show that increases in the stability of hippocampal memory representations after learning (which predicts successful memory consolidation) are mediated through emergent network-wide resonance and locking of neuronal activity to network oscillations. These changes arise in the network as a function of changes to network structure during learning, and mirror experimental findings in the hippocampus. Finally, we show that input-dependent pattern formation (e.g. “replay”) in the hippocampus during sleep states, together with spike timing dependent plasticity (STDP)-based memory consolidation, leads to universal network activity reorganization. This reorganization generates heterogeneous changes in neuronal spiking frequency, similar to what has been observed in a variety of brain circuits across periods of sleep. Our results support the hypothesis that sleep plays an active role in memory consolidation by switching the hippocampal network from rate-based to phase-based information representation. The mechanisms through which this occurs supports the integration of heterogeneous cell populations into memory traces. <h3>Significance Statement</h3> In this study, we provide a mechanistic explanation of how sleep selectively facilitates memory consolidation, through recruitment of heterogeneous neuronal populations and structural reorganization of the network into an engram. Specifically, we show that emergent theta band oscillations during sleep facilitate stabilization of memory representations via spike timing dependent reinforcement. This stabilization, together with STDP, allows for systematic reorganization of synaptic connections within these populations, universally redistributing firing rates of participating neurons. Simultaneously, network oscillations facilitate a switch from rate-to phase-coding of information among neuronal populations with highly heterogenous firing frequencies, incorporating more neurons into the engram. Our results reconcile discrepant findings on network reorganization during sleep, and demonstrate a clear mechanism for both strengthening and weakening of synaptic efficacy during sleep.
Gas Gangrene Associated with Occult Cancer
Authors: David J. Schneider, J. Spence Reid
Journal: New England Journal of Medicine (2000)

Figure 1. A 78-year-old man with cardiac disease presented with pain in his left elbow of several hours' duration in the absence of trauma. Examination of the elbow disclosed no abnormalities, and he was admitted with a tentative diagnosis of atypical angina. His white-cell count was 4400 per cubic millimeter. Several hours later, ecchymoses and blistering of the left arm developed (Panel A), with severe pain and soft-tissue crepitus near the elbow. The patient rapidly became unresponsive and severely hypotensive and was immediately transported to the operating room while receiving intravenous penicillin. Radiographs in the operating room revealed subcutaneous gas . . .
Plain Packaging of Tobacco Products in Australia
Authors: Andrew D. Mitchell, David M. Studdert
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Immunoblotting analysis of concanavalin A ‐isolated allergens of <i>Candida albicans</i>
Authors: J. Savolainen, M. Viander, R. Einarsson, A. Koivikko
Journal: Allergy (1990)

The carbohydrate‐containing Traction of Candida albicans was isolated from the crude extract with ConA Sepharose affinity chromatography and studied by IgE‐immuno‐blotting with individual and pooled sera from C. albicans ‐allergic subjects. In the ConA‐bound fraction there was a diffuse IgE binding in the high molecular weight area which also gave a carbohydrate stain (PAS). A distinct band corresponding to a molecular weight of 70 kD bound specific IgE antibodies. This glycoprotein, presumably a mannoprotein, gave a weak carbohydrate staining and a strong protein staining. further biochemical studies are needed to reveal the exact nature of the epitopes in the ConA‐bound mannose‐containing fraction of C. albicans.
The accuracy of multislice spiral computed tomography using a novel ECG-gated image reconstruction method for the assessment of coronary artery stenosis
Authors: Toshiyuki Horie, Yuichi Sato, Masahiko Kato, Fumio Inoue, Takako Imazeki, Akihiro Yoshimura, Naoya Matsumoto, Motoichiro Takahashi, Katsuo Kanmatsuse
Journal: Journal of the American College of Cardiology (2003)
Mismatched Ventilation-Perfusion Defect in a Case of Bronchogenic Carcinoma
Authors: KYOICHI NOMURA, TATSUYA MIYAMAE, KEIICHIRO YAMAMOTO, MASAMI MASHIMO, YUTAKA DOHI
Journal: Clinical Nuclear Medicine (1980)

NOMURA, KYOICHI M.D.*; MIYAMAE, TATSUYA M.D.†; YAMAMOTO, KEIICHIRO M.D.*; MASHIMO, MASAMI M.D.†; DOHI, YUTAKA M.D.* Author Information
Balancing safety and adventure
Authors: J Hollis-Triantafillou
Journal: BMJ (1994)

The atmosphere when I arrived at our KAPI* centre that morning was uncharacteristically subdued. The members were sitting around talking quietly and the social worker was in tears. The cause: Kyria Poppy, star performer of the theatre group and leader of the choir, had died suddenly the previous day and her funeral was to take place that afternoon.

The choir, a fairly recent innovation, had flourished and been invited to give a performance at a neighbouring KAPI, followed by refreshments and, of course, dancing at the local taverna. Kyria Poppy, flushed with success, food, and a little unaccustomed wine, had risen to take the floor in the Kalamatiano and had been …
Secretory response to secretin in a patient with diarrhoea and the Zollinger-Ellison pattern of gastric secretion
Authors: H. Petersen, J. Myren, I. Liavag
Journal: Gut (1969)

In a woman with diarrhoea and the Zollinger-Ellison pattern of gastric secretion, the secretion of fluid and bicarbonate into the duodenum in response to secretin was found to be significantly greater than in controls. No pancreatic tumour was found at operation. The pancreas was, however, larger than normal. The patient did not show symptoms of peptic ulcer disease until vagotomy and pyloroplasty had been performed. A capacity to secrete large amounts of bicarbonate was believed to be the explanation of why she was able to tolerate great amounts of acid.
Ombitasvir/paritaprevir/r and dasabuvir plus ribavirin in HCV genotype 1-infected patients on methadone or buprenorphine
Authors: Jacob Lalezari, J. Greg Sullivan, Peter Varunok, Edward Galen, Kris V. Kowdley, Vinod Rustgi, Humberto Aguilar, Franco Felizarta, Barbara McGovern, Martin King, Akshanth R. Polepally, Daniel E. Cohen
Journal: Journal of Hepatology (2015)

Hepatitis C virus (HCV)-infected patients with a history of injection drug use have low rates of initiation and completion of interferon-based therapies. This study evaluated efficacy, safety, and pharmacokinetics of a 12-week all-oral regimen of ombitasvir/paritaprevir/ritonavir and dasabuvir+ribavirin in HCV genotype 1-infected patients on stable opioid replacement therapy.This was a phase II, multicenter, open-label, single-arm study in treatment-naïve or peginterferon/ribavirin treatment-experienced HCV genotype 1-infected patients on methadone or buprenorphine±naloxone. Patients received 12weeks of co-formulated ombitasvir/paritaprevir/ritonavir (25mg/150mg/100mg once daily) and dasabuvir (250mg twice daily)+weight-based ribavirin. The primary efficacy endpoint was sustained virologic response 12 weeks post-treatment.Thirty-eight non-cirrhotic patients on chronic methadone (n=19) or buprenorphine (n=19) were enrolled. A total of 37 patients (97.4%) had a sustained virologic response 12 weeks post-treatment. No patient had a viral breakthrough or relapse. One patient discontinued due to serious adverse events unrelated to study drug (cerebrovascular accident and sarcoma). The most frequent adverse events were nausea, fatigue, and headache. Eight patients had on-treatment hemoglobin concentrations <10g/dl. Pharmacokinetic analyses indicated no clinically meaningful impact of methadone or buprenorphine on ombitasvir, paritaprevir, ritonavir, dasabuvir, or dasabuvir M1 metabolite exposures. No dose adjustments of methadone or buprenorphine were required.The interferon-free regimen of ombitasvir/paritaprevir/ritonavir and dasabuvir+ribavirin for 12weeks was well tolerated and achieved sustained virologic response in 97.4% of patients on opioid substitution therapy in this study. This all-oral regimen may provide an effective alternative to interferon-based therapies for HCV-infected patients with a history of injection drug use.
Coexistent Sarcoidosis, Erythema Nodosum, and Gout
Authors: Allen Chetrick
Journal: JAMA (1963)

BECAUSE of its multiplicity of tissue involvement, sarcoidosis is a disease which may present in various ways. Arthritis has been reported to occur in 10% to 25% of cases of sarcoidosis and arthritic symptoms may be the first manifestation of the disease.<sup>1</sup>Yet this aspect of sarcoidosis has not been sufficiently stressed in the literature. The peripheral joints are primarily affected and the clinical picture may simulate rheumatic fever or rheumatoid arthritis.<sup>2, 3</sup>In other instances a polyarthritis is an integral part of the syndrome complex of erythema nodosum. More recently another type of arthritis, gout, has been found by Kaplan and Klatskin<sup>4</sup>in association with sarcoidosis. These authors documented cases of three patients with coexistent sarcoidosis, psoriasis, and gout and noted an incidence of hyperuricemia in approximately 20% of patients with sarcoidosis in whom serum uric acid determinations were made. The following case is of interest
Evaluation of `round cells' in semen analysis: a comparative study
Authors: E. Johanisson
Journal: Human Reproduction Update (2000)

The aims of this review are to evaluate the morphological differences between `round cells' of spermatogenic and non-spermatogenic origin in semen. The latter group includes inflammatory cells like neutrophils, lymphocytes, and macrophages, and epithelial cells. A comparison was made between non-spermatogenic cells in semen samples and inflammatory cells in blood smears, using various staining procedures commonly used in routine andrology laboratories. The result presented in this review confirmed previously published data. In blood smears as well as in semen samples, only neutrophil leukocytes (both eosinophilic and basophilic) showed a positive reaction when exposed to the peroxidase stain. Lymphocytes, macrophages and other `round cells' such as epithelial cells and spermatogenesis cells remained negative. It could be concluded that the neutrophil polymorphonuclear leukocytes were the only `round cells' showing a positive reaction in the semen samples. The presence of specifically stained neutrophils in semen was considered to be compatible with an infection and/or a subsequent inflammatory reaction in the male genital tract. The potential influence of inflammatory cells in the sperm samples on infertility/subfertility is discussed. However, the question of determining if morphologically abnormal, degenerated spermatids are still capable of fertilizing an oocyte in vitro is not addressed in this review.
PREDICTORS FOR CROSSOVER FROM RADIAL TO FEMORAL APPROACH IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION FOR UNPROTECTED LEFT MAIN DISEASE
Authors: Young Jin Youn, Junghan Yoon, Jun-Won Lee, Joong Kyung Sung, Woo Taek Kim, Sung-Gyun Ahn, Jang-Young Kim, Byung-Soo You, Seung-Hwan Lee, Kyung-Hoon Choe
Journal: Journal of the American College of Cardiology (2011)
Clinical improvement after unusual avoidance measures in the home of an atopic dermatitis patient
Authors: H. S. M. Kort, W. J. Koers, A. M. T. van Nes, E. Young, J. Vorenkamp, B. G. Wolfs, J. E. M. H. van Bronswijk
Journal: Allergy (1993)

A 27‐year‐old female office clerk with widespread atopic dermatitis (AD) since infancy appeared to be highly sensitized and exposed to molds, storage mites, and chicken feathers and moderately sensitized to house‐dust mites and grass and birch pollens. Hardly any textiles were present in her home; that is, only 28 m 2 , which is less than 25% of the Dutch national average. The causal relationship between eczema and molds plus storage mites in this case of AD was strengthened by the positive effect of an unusual, multidisciplinary home‐sanitation program involving cleaning of mineral surfaces and ventilation improvement. This home‐sanitation program led to a gradual drop of total IgE and clinical symptom scores to 21% and 13%, respectively, of the original values.
NOTE ON RUMBOLD'S METHOD OF TREATMENT OF CATARRHAL INFLAMMATIONS OF THE UPPER AIR PASSAGES.
Authors: ELY McCLELLAN
Journal: JAMA (1889)

My note published inThe Journalof August 18, has occasioned so many letters asking for further information as to the details of the method therein advocated, that I feel called upon to present a second paper on the subject in which the attempt will be made to detail each step in the procedure so plainly, that it will enable those who may wish to avail themselves of the method of treatment, to procede in its practical administration without delay. As stated in my former paper, the method of treatment which is advocated, originated with and has been elaborated by, Dr, Rumbold, whose experience in the treatment of the diseases of the throat, nose and ears dates back to 1855, and who has used vaseline since 1872. The history of this therapeutic measure is as follows: In 1866, Dr, Rumbold obtained the glass spray producers of Maunder, to each of
Binding of [3H]-5-hydroxytryptamine to human coronary artery and bypass graft vessels
Authors: P. L. Dahm, M. Bodelsson, K. Tornebrandt, J. R. Muddle, R. M. Sykes, M. Yacoub, M. R. Dashwood
Journal: Cardiovascular Research (1996)

5-Hydroxytryptamine (5-HT) has a wide range of vascular effects mediated via specific receptors and it has been suggested to be a mediator in ischemic heart disease. The aim of the present study was to localise the 5-HT receptors within the vessel wall. Epicardial coronary arteries obtained from patients undergoing cardiac transplantation, internal mammary arteries from heart donors and saphenous veins from patients undergoing coronary bypass surgery, were sectioned and incubated with [3H]-5-HT for in vitro receptor autoradiography. Microscopic analysis of high resolution autoradiographic images revealed a similar pattern of [3H]-5-HT binding in epicardial coronary and internal mammary artery, where it predominated in the lamina muscularis. In the saphenous vein, binding increased towards the adventitia which showed dense, displaceable binding to the vasa vasorum as well as to nerve-like structures, from which binding was only partially displaced. Computer-assisted densitometric analysis of low resolution autoradiographs revealed a high degree of specific binding to all vessels examined. The distribution of the [3H]-5-HT binding is different in the saphenous vein compared to epicardial coronary and internal mammary artery. The dense binding to vasa vasorum in the saphenous vein suggests a role for 5-HT in closure of these nutrient vessels, which could contribute to the formation of atherosclerotic changes in saphenous vein grafts.
Inducible NO Synthase–Dependent <i>S</i> -Nitrosylation and Activation of Arginase1 Contribute to Age-Related Endothelial Dysfunction
Authors: Lakshmi Santhanam, Hyun Kyo Lim, Hyun Kyoung Lim, Victor Miriel, Tashalee Brown, Meet Patel, Sarit Balanson, Sungwoo Ryoo, Mirinda Anderson, Kaikobad Irani, Firdous Khanday, Luigi Di Costanzo, Daniel Nyhan, Joshua M. Hare, David W. Christianson, Richard Rivers, Artin Shoukas, Dan E. Berkowitz
Journal: Circulation Research (2007)

Endothelial function is impaired in aging because of a decrease in NO bioavailability. This may be, in part, attributable to increased arginase activity, which reciprocally regulates NO synthase (NOS) by competing for the common substrate, L-arginine. However, the high Km of arginase (>1 mmol/L) compared with NOS (2 to 20 micromol/L) seemingly makes direct competition for substrate unlikely. One of the mechanisms by which NO exerts its effects is by posttranslational modification through S-nitrosylation of protein cysteines. We tested the hypothesis that arginase1 activity is modulated by this mechanism, which serves to alter its substrate affinity, allowing competition with NOS for L-arginine. We demonstrate that arginase1 activity is altered by S-nitrosylation, both in vitro and ex vivo. Furthermore, using site-directed mutagenesis we demonstrate that 2 cysteine residues (C168 and C303) are able to undergo nitrosylation. S-Nitrosylation of C303 stabilizes the arginase1 trimer and reduces its Km value 6-fold. Finally, arginase1 nitrosylation is increased (and thus its Km decreased) in blood vessels from aging rats, likely contributing to impaired NO bioavailability and endothelial dysfunction. This is mediated by inducible NOS, which is expressed in the aging endothelium. These findings suggest that S-nitrosylated arginase1 can compete with NOS for L-arginine and contribute to endothelial dysfunction in the aging cardiovascular system.