The Control of the Secretion of Pancreatic Juice and Bile
Authors: FRANK P. BROOKS
Journal: Annals of Internal Medicine (1961)

Editorials1 September 1961The Control of the Secretion of Pancreatic Juice and BileFRANK P. BROOKS, M.D., F.A.C.P.FRANK P. BROOKS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-3-528 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe importance of pancreatic juice and bile in the normal digestion of food is generally accepted. Physicians are familiar with the steatorrhea and malnutrition of patients with chronic pancreatitis and obstruction of the common bile duct as examples of derangements of the normal conditions. In recent years the study of secretion as an example of active transport has been applied to the mechanisms of formation of bile (1), and carbonic anhydrase inhibitors have been used to study the formation of pancreatic juice and bile (2, 3). Such studies have led to the concept that bile is a mixture of bile...References1. BRAUER RW: Mechanisms of bile secretion, J. A. M. A. 169: 1462, 1959. CrossrefMedlineGoogle Scholar2. WHEELERRAMOS HOOL: Determinants of the flow and composition of bile in the unanesthetized dog during constant infusions of sodium taurocholate. J. Clin. Invest. 39: 161, 1960. CrossrefMedlineGoogle Scholar3. DREILINGJANOWITZ DAHD: The secretion of electrolytes by the human pancreas. Amer. J. Digest. Dis. 4: 137, 1959. CrossrefGoogle Scholar4. PAVLOV IP: The Work of the Digestive Glands, Charles Griffin & Co., Ltd., London, 1902. Google Scholar5. BAYLISSSTARLING WMEH: The mechanism of pancreatic secretion. J. Physiol. 28: 321, 1902. CrossrefGoogle Scholar6. THOMAS JE: The External Secretion of the Pancreas, Charles C Thomas, Springfield, Ill., 1950. Google Scholar7. HARPERRAPER AAHS: Pancreozymin, a stimulant of the secretion of pancreatic enzymes in extracts of the small intestine. J. Physiol. 102: 115, 1943. CrossrefMedlineGoogle Scholar8. HARPER AA: Physiologic factors regulating pancreatic secretion. Gastroenterology 36: 386, 1959. CrossrefMedlineGoogle Scholar9. BURTONEVANSHARPERHOWATOLEESKYSCOTTVARLEY PDGAAHTSJEH: A test of pancreatic function in man based on the analysis of duodenal contents after administration of secretin and pancreozymin. Gut 1: 111, 1960. CrossrefMedlineGoogle Scholar10. BURTONHARPERHOWATSCOTTVARLEY PAAHTJEH: The use of cholecystokinin to test gallbladder function in man. Gut 1: 193, 1960. CrossrefMedlineGoogle Scholar11. WHIPPLE GH: The origin and significance of the constituents of the bile. Physiol. Rev. 2: 440, 1922. CrossrefGoogle Scholar12. GROSSMANJANOWITZRALSTONKIM MIHDHKS: The effect of secretin on bile formation in man. Gastroenterology 12: 133, 1949. CrossrefMedlineGoogle Scholar13. WANGGROSSMAN CCMI: Physiological determination of release of secretin and pancreozymin from intestine of dogs with transplanted pancreas. Amer. J. Physiol. 164: 527, 1951. CrossrefMedlineGoogle Scholar14. COMFORTOSTERBERG MWAE: Pancreatic secretion in man after secretin and mecholyl. Arch. Intern. Med. 66: 688, 1940. CrossrefGoogle Scholar15. KYLEMACHELLALORBERHILSMANREINHOLDBROWN GCTESHJTJGJC: The use of urecholine as a stimulant of the external secretion of the pancreas. Gastroenterology 16: 285, 1950. CrossrefMedlineGoogle Scholar16. DREILINGJANOWITZ DAHD: Inhibitory effect of new anticholinergics on the basal and secretin stimulated pancreatic secretion in patients with and without pancreatic disease. Amer. J. Digest. Dis. 5: 639, 1960. CrossrefMedlineGoogle Scholar17. BYKOV KM, in A Textbook of Physiology, ed. by Bykov, K. M., Foreign Language Publishing House, Moscow, 1958. Google Scholar18. HARPERKIDDSCRATCHERD AACT: Vagovagal reflex effects on gastric and pancreatic secretion and gastrointestinal motility. J. Physiol. 148: 417, 1959. CrossrefMedlineGoogle Scholar19. TANKELHOLLANDER HIF: The relation between pancreatic secretion and blood flow. A review. Gastroenterology 32: 633, 1957. CrossrefMedlineGoogle Scholar20. HOKINHOKIN LEMR: Studies of pancreatic tissue in vitro. Gastroenterology 36: 368, 1959. CrossrefMedlineGoogle Scholar21. TANTURIIVY CAAC: A study of the effect of vascular changes in the liver and the excitation of its nerve supply on the formation of bile. Amer. J. Physiol. 121: 61, 1938. CrossrefGoogle Scholar22. SNYDER CD: Experimental studies on vagal control of the functions of the liver. Amer. J. Physiol. 118: 345, 1937. CrossrefGoogle Scholar23. CANNONURIDIL WBJE: Some effects on the denervated heart of stimulating the nerves of the liver. Amer. J. Physiol. 58: 353, 1921-22. CrossrefGoogle Scholar24. GUBARORESHUK AVFA: Influence of removal of the cortex of the large cerebral hemispheres on bile-forming function of the liver. Bull. Exper. Biol. Med. USSR 42: 736, 1956. CrossrefGoogle Scholar25. LEBEDEVA LI: The bile secreting function of the liver and intestinal interceptors. Sechenov Physiol. J. USSR 45: 76, 1959. Google Scholar26. KOSTERSHAPIROLERNER HAH: On the rate of secretion of bile. Amer. J. Physiol. 115: 23, 1936. CrossrefGoogle Scholar27. FRIEDMANSNAPE MHWJ: Comparative effectiveness of extracts of intestinal mucosa in stimulating the external secretions of the pancreas and the liver. Fed. Proc. 4: 21, 1945. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Physiology The School of Medicine University of Pennsylvania Philadelphia 4, Penna PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1961Volume 55, Issue 3Page: 528-531KeywordsBileBile ductsChronic pancreatitisDigestionFoodMalnutrition Issue Published: 1 September 1961 PDF DownloadLoading ...