tbuckley/cabot-search huggingface dataset:
Electrophysiologic substrate for ventricular tachycardia: correlation of properties in vivo and in vitro.
Authors: D A Richards, G J Blake, J F Spear, E N Moore
Journal: Circulation (1984)

Cardiac electrophysiologic studies were performed in three control dogs and in nine dogs with previous (8 to 22 days) anterior myocardial infarction. During programmed stimulation, no control dog had more inducible ventricular fibrillation (VF) or tachycardia (VT), three dogs with infarcts had inducible VF and six had inducible VT. Recordings in vivo were made via a plaque electrode containing 10 bipolar electrodes (3.0 x 1.5 cm) placed on the epicardial surface of the anteroapical left ventricle. Subsequently, epicardial strips (2 mm thick) from beneath the plaque were prepared for studies in vitro. Electrogram durations were significantly greater in dogs with infarcts than in control dogs both in vivo (p less than .05) and in vitro (p less than .001). Electrogram amplitudes were significantly lower in dogs with VT in vivo (p less than .05) and in vitro (p less than .001). In control animals activation was continuous and most rapid in the direction of fiber orientation; there were areas of slow and/or discontinuous conduction in all dogs with infarcts. In one case, sustained reentrant beating in vitro was caused by functional unidirectional block and microreentry at a site of continuous electrical activity during VT in vivo. Reentrant beating in vitro persisted in 0.5 cc of isolated tissue. We conclude that broad low-amplitude electrograms in vivo and in vitro depict local areas of slow and/or discontinuous conduction, that the intrinsic asymmetry of cardiac activation due to fiber orientation is accentuated by infarction and may predispose to intraventricular reentry, and that intraventricular reentrant circuits that may be present on the epicardial surface may persist in a volume of myocardial tissue as small as 0.5 cc.
Epidemic Neuromyasthenia: Outbreak among Nurses at a Children's Hospital
Authors: M. J. Dillon, W. C. Marshall, J. A. Dudgeon, A. J. Steigman
Journal: BMJ (1974)

Between August 1970 and January 1971 nearly 150 of the staff of a London teaching hospital were affected by an illness with features in common with what is currently known as epidemic neuromyasthenia. Symptomatology was protean, clinical findings minimal, relapses frequent, and results of laboratory investigations, including virological studies, were generally negative. Most of the patients were nurses. Care was taken to minimize anxiety and fear in a vulnerable population, and laboratory investigations were limited in number for this reason.
Surreptitious Self-administration of Epinephrine Resulting in 'Pheochromocytoma'
Authors: Harry R. Keiser
Journal: JAMA (1991)

<h3>SELECTED CASE</h3> A 35-YEAR-OLD woman with a possible pheochromocytoma was referred to the National Institutes of Health (NIH) from Pittsburgh, Pa. Her symptoms started in December 1987, when she developed headache, tremor, tachycardia, and mild hypertension after an injection of novocaine and epinephrine. Soon the episodes began to occur spontaneously. She often went to a local emergency department, where her blood pressure was as high as 160/100 mm Hg and her heart rate as high as 140 beats per minute. Her urinary epinephrine output was 1600 nmol/d (normal, &lt;165 nmol/d). Her plasma norepinephrine (NE) level was 2.9 nmol/L (normal, &lt;4.4 nmol/L) and plasma epinephrine, 2.8 nmol/L (normal, &lt;0.55 nmol/L). In February 1988, a clonidine suppression test was performed. Basal plasma NE level was normal (1.4 nmol/L) and was suppressed normally to 0.49 nmol/L; basal plasma epinephrine level was markedly elevated (1.8 nmol/L), and was also suppressed into the normal range
Erlotinib-Mediated Inhibition of EGFR Signaling Induces Metabolic Oxidative Stress through NOX4
Authors: Kevin P. Orcutt, Arlene D. Parsons, Zita A. Sibenaller, Peter M. Scarbrough, Yueming Zhu, Arya Sobhakumari, Werner W. Wilke, Amanda L. Kalen, Prabhat Goswami, Francis J. Miller, Douglas R. Spitz, Andrean L. Simons
Journal: Cancer Research (2011)

Redox regulation of epidermal growth factor receptor (EGFR) signaling helps protect cells against oxidative stress. In this study, we investigated whether the cytotoxicity of an EGFR tyrosine kinase inhibitor, erlotinib (ERL), was mediated by induction of oxidative stress in human head and neck cancer (HNSCC) cells. ERL elicited cytotoxicity in vitro and in vivo while increasing a panel of oxidative stress parameters which were all reversible by the antioxidant N-acetyl cysteine. Knockdown of EGFR by using siRNA similarly increased these oxidative stress parameters. Overexpression of mitochondrial targeted catalase but not superoxide dismutase reversed ERL-induced cytotoxicity. Consistent with a general role for NADPH oxidase (NOX) enzymes in ERL-induced oxidative stress, ERL-induced cytotoxicity was reversed by diphenylene iodonium, a NOX complex inhibitor. ERL reduced the expression of NOX1, NOX2, and NOX5 but induced the expression of NOX4. Knockdown of NOX4 by using siRNA protected HNSCC cells from ERL-induced cytotoxicity and oxidative stress. Our findings support the concept that ERL-induced cytotoxicity is based on a specific mechanism of oxidative stress mediated by hydrogen peroxide production through NOX4 signaling.
SYMPATHECTOMY FOR INTRACTABLE PAIN IN INOPERABLE CANCER OF THE CERVIX
Authors: J. P. GREENHILL
Journal: JAMA (1933)

The results obtained with radiation therapy in inoperable malignant growth are most unsatisfactory. In the majority of instances the doomed individual suffers from excruciating pain which necessitates the almost continuous use of narcotics. The pain is due to the extension of the growth to and about adjacent nerves. This is particularly true of malignant growths in the female genitalia, notably carcinoma of the cervix of the uterus. At present, only two satisfactory ways exist in which the constant suffering may be alleviated. Both are operative procedures. One, known as cordotomy, consists of section of the anterolateral columns of the spinal cord. The other, known as sympathectomy, consists, in cases of malignant growths of the pelvis, in removal of the so-called presacral nerve or superior hypogastric plexus.  Cordotomy will relieve pain, but it is an operation that should be carried out only by one skilled in neurologic surgery. The operation requires
Acute Idiopathic Polyneuritis and Idiopathic Thrombocytopenic Purpura
Authors: Paul T. Gross
Journal: JAMA (1980)

ACUTE idiopathic polyneuritis (AIP) and idiopathic thrombocytopenic purpura (ITP) are both thought to be examples of autoimmune diseases, although different immune mechanisms are active in each disorder.<sup>1,2</sup>To my knowledge, they have never been reported to occur in the same patient simultaneously. I recently had the opportunity to observe a patient who had both illnesses several days after an upper respiratory tract infection. This case is of interest because immune complexes play a prominent role in the development of ITP,<sup>2</sup>and a pathogenic role of immune complexes has been suggested in AIP, which is otherwise considered to be a cell-mediated immune process.<sup>3</sup> <h3>Report of a Case</h3> A 30-year-old woman was admitted to the University of Wisconsin Hospitals on June 9, 1978, complaining of profound weakness. She had been well until ten days before admission, when an upper respiratory tract infection developed, consisting of coryza and sore throat,
Book: In the Land of Pain
Authors: A. Ellis
Journal: BMJ (2002)

Alphonse Daudet Ed Julian Barnes Jonathan Cape, £10, pp 102 ISBN 0 224 06267 0 Rating: ![Graphic][1]</img>![Graphic][2]</img> Alphonse Daudet was a novelist who lived in France in the second half of the 19th century. At the age of 17 he contracted syphilis, which lay dormant for some 20 years. He eventually developed locomotor ataxia as a result of tabes dorsalis, when the disease moved to his neurological system. He died in 1897 at the age of 57. For … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif
A SIMPLE BLOODLESS OPERATION FOR HEMORRHOIDS
Authors: LOUIS J. HIRSCHMAN
Journal: JAMA (1910)

It is my intention to give briefly my technic for the removal of certain forms of internal hemorrhoids without the profuse hemorrhage with which this operation is usually associated in the minds of most practitioners. Having observed that most patients suffering from hemorrhoids of the internal variety are more or less anemic from the continued and constant loss of blood, as a result of their hemorrhoidal trouble, I began three years ago to use a technic which would minimize operative hemorrhage and conserve the patient's blood-supply. With this aim in view, I have developed and have been using a very simple technic which is applicable under local as well as general anesthesia and therefore can be used in those weak, run-down patients suffering from any of the wasting diseases in whom the use of a general anesthetic would be inadvisable if not positively dangerous. The method is adapted to the
Continuing Medical Education: an international reality
Authors: F. Braido, T. Popov, I. J. Ansotegui, J. Gayraud, K. L. Nekam, J. L. Delgado, H. J. Malling, S. Olson, M. Larchè, A. Negri, G. W. Canonica
Journal: Allergy (2005)

We are all aware today of the growing interest in continuing medical education (CME) programmes in many European Countries and it is important to understand why and how CME could become an international reality. It is obvious that patients need a good doctor--the best possible--as far as medical knowledge, attention to the patient's quality of life and cost-control is concerned. All European health care systems have to take into consideration everything that causes patient dissatisfaction, risk management and unjustified expenses. An example is the increase of claims and complaints against doctors and the strong attention of patients to medical procedures. In other words, medicine worldwide is becoming a service industry and has to consider quality and quantity of performances as well as to pay attention to personal responsibility. The object of our work is to evaluate the CME systems present in Europe, to show the work done on CME by the CME Committee of the European Academy of Allergology and Clinical Immunology and to highlight the Consensus Report on CME approved by an international panel of CME experts.
Self injury and mental handicap.
Authors: P G Dale
Journal: BMJ (1987)

Self injury and mental handicap SIR,-Like suicide, self injury is a form of self mutilation and is not always a form of attention seeking due to boredom, as Dr Brian Kirman assumes (31 October, p 1086).Suicide and self mutilation are often forms of aggression turned inwards and associated with aggression to others.This is particularly true ofthe mentally retarded.Control ofaggression is difficult but notoriously so in those severely retarded.'From 1969 onwards there have been several reports on the usefulness of lithium in patients exhibiting aggression.The patients included groups of delinquents, psychotics, and the ment- ally handicapped.The larger studies indicate a positive response in some 70-75% of cases.2These figures were confirmed in the first published multicentre double blind trial of lithium in mentally handicapped patients, published last May.3Until the survey quoted by Dr Kirma. is published it is not possible to say whether the authors were aware of this but it seems unlikely.Lithium is not necessarily a cure and is usually given only when all other methods have failed, although a plea for its earlier use in these patients was made recently.5It seems helpful in relieving aggression, including self mutilation, in these patients, which distresses them, their relatives, and staff.The grave shortages of staff trained in behavioural techniques may to some extent be relieved if this element is used with effect.The patient may become more receptive to this type of treatment.
Time to Detectable Metastatic Disease in Patients with Rising Prostate-Specific Antigen Values following Surgery or Radiation Therapy
Authors: Susan F. Slovin, Andrew S. Wilton, Glenn Heller, Howard I. Scher
Journal: Clinical Cancer Research (2005)

Abstract Purpose: To determine factors associated with the development of radiographic metastatic progression for patients with recurrent prostate cancer following surgery and/or radiation therapy with prostate-specific antigen (PSA) doubling times of &amp;lt;12 months. Experimental Design: One hundred and forty-eight patients with rising PSA values after primary therapy and a PSA doubling time of &amp;lt;12 months enrolled on clinical protocols were followed and monitored at protocol-specified intervals with examinations, PSA determinations, and imaging studies that included a computed tomography or magnetic resonance imaging and bone scan until metastases were detected. Metastasis-free survival was estimated using the Kaplan-Meier method and factors predictive of progression-free survival were estimated using the proportional hazards model. A nomogram based on the Cox model was constructed. Results: Metastatic events were documented in 74% (110 of 148) of patients during the follow-up period. The median progression-free survival was 19 months, with 3- and 5-year metastatic progression–free survival of 32% and 16%, respectively. T stage (P = 0.07) and Gleason grade (P = 0.006) at the time of diagnosis, PSA values at the time of protocol entry (P &amp;lt; 0.001), and PSA doubling time (P &amp;lt; 0.001) were associated with progression in univariate analysis. These were combined into a nomogram to assess risk for an individual patient. Conclusions: Tumor characteristics at the time of diagnosis, PSA doubling time following relapse, and the PSA value at the time of the protocol are predictive of metastatic progression. Because the PSA value at the time of monitoring was predictive, early treatment to prevent metastatic progression is favored.
Federal Grant Questioned
Authors: Mike Mitka
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Have you heard who's on Ward 3?
Authors: T. Greenhalgh
Journal: BMJ (1999)

I was once taken to hospital with peritonitis. Like most patients who are well enough to join the queue for an NHS surgical bed, I spent several hours in the accident and emergency department. The admitting doctor apologised in advance for the wait, and wrote me up for a generous slug of morphine.

I had previously spent two years working as a medical registrar at the same hospital. For half a day, I drifted in and …
An organ culture model for the study of pemphigus acantholysis
Authors: BENO MICHEL, CHI SOWN KO
Journal: British Journal of Dermatology (1977)

Journal Article An organ culture model for the study of pemphigus acantholysis Get access BENO MICHEL, BENO MICHEL Division of Dermatology, Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, U.S.A. Reprint requests to: Dr Beno Michel, Divison of Dermatology, University Hospitals of Cleverland, 2065 Adelbert Road, Cleverland, Ohio 44106, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar CHI SOWN KO CHI SOWN KO Division of Dermatology, Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 96, Issue 3, 1 March 1977, Pages 295–302, https://doi.org/10.1111/j.1365-2133.1977.tb06141.x Published: 01 March 1977
Effect of Surveillance on the Number of Hysterectomies in the Province of Saskatchewan
Authors: Frank J. Dyck, Fergus A. Murphy, J. Kevin Murphy, David A. Road, Martin S. Boyd, Edna Osborne, Dan de Vlieger, Barbara Korchinski, Carl Ripley, Alfred T. Bromley, Peter B. Innes
Journal: New England Journal of Medicine (1977)

In 1972 the College of Physicians and Surgeons of Saskatchewan appointed a committee to study hysterectomies because the Saskatchewan Department of Health had data showing that the annual number of hysterectomies carried out in the province had increased by 72.1 per cent between 1964 and 1971, whereas the number of women over 15 years of age had increased by 7.6 per cent. The committee compiled a list of indications for hysterectomy. Any hysterectomy carried out for one of these reasons was classified as justified, and the remainder as unjustified. Five hospitals were reviewed in 1970 and a further two in 1973. In 1974, all seven hospitals were reviewed again. In these hospitals, the average proportion of unjustified hysterectomies had dropped from 23.7 per cent at the time of the first review to 7.8 per cent in 1974. The total number of hysterectomies in the province dropped by 32.8 per cent between 1970 and 1974.
Apa I polymorphism in the vitamin D receptor gene may affect the parathyroid response in Japanese with end-stage renal disease
Authors: Keitaro Yokoyama, Takashi Shigematsu, Toshihiko Tsukada, Yousuke Ogura, Fumi Takemoto, Sigeko Hara, Akira Yamada, Yoshindo Kawaguchi, Tatsuo Hosoya
Journal: Kidney International (1998)
Debbie's Dying: Mercy Killing and the Good Death
Authors: Kenneth L. Vaux
Journal: JAMA (1988)

MOST of the condemnatory response to "It's Over, Debbie"<sup>1</sup>has rightly claimed that what (apparently) transpired that night was unconscionable. One does not stumble angrily into the night and decide profound matters of life and death for another human being. This strange narrative does not tell us whether Debbie wanted simply to be relieved of pain or released from intolerable suffering; whether the family consented or what the nurses or chaplains on call advised; or whether the attending or primary physician, if one existed, authorized the action. The whole process, from beginning to end, was morally unacceptable. A deeper question, however, lies behind the widespread interest in this one reprehensible action—the question that troubles us all. As I lie dying, will I be offered humane care, will I be done in too soon by some expediency, or will I be subjected to terminal torture? Euthanasia does not refer to
Does Testing Accelerate Defibrillator Failure?
Authors: G. Bashein
Journal: JAMA (1991)

<h3>To the Editor.—</h3> I wish to make two points regarding the recent article on defibrillator failures.<sup>1</sup> First, the Working Group's recommendation for testing defibrillators every shift may actually hasten their failure due to the added wear and tear on capacitors, switches, relay contacts, and other components.<sup>2</sup>Another argument advanced for testing seldom-used defibrillators is to help personnel maintain their familiarity with the equipment and its operation. However, defibrillators in busy paramedic services, coronary care units, and cardiac operating rooms undergo frequent "testing" by actual use, and the personnel also have the benefit of frequent practice in maintaining their familiarity with the equipment. Thus, with minimal loss of training value it may be possible to lengthen the mean time to failure of heavily used defibrillators by not testing them so often. The Emergency Care Research Institute has recommended only weekly test discharging at 50 J (to minimize wear and
Equilibrium Radionuclide Venthculography in Duchenne??s Cardiomyopathy
Authors: S NAGAMACHI, S JINNOUCHI, K INOUE, S INOUE, H HOSHI, S ONO, H YOSHIMURA, T OHNISHI, S FUTAMI, K WATANABE
Journal: Clinical Nuclear Medicine (1990)

Myocardial dysfunction in 14 patients with Duchenne's muscular dystrophy (DMD) was evaluated by Tc-99m HSA multigated radionuclide ventriculography (MGRV). Follow-up studies were performed on eight patients for 5 years. Left ventricular ejection fraction and standard deviation of the phase angle were abnormal in all patients older than 15 years. Hypokinetic changes and phase delay were recognizable in most patients older than 17 years. Peak filling rate decreased in patients older than 17 years. MGRV was considered an effective method for evaluating serial changes in cardiomyopathy of patients with DMD.
Drop the bill--and then what?
Authors: R. Madhok
Journal: BMJ (2012)

The application of nuclear magnetic resonance (NMR) imaging to the diagnosis of orbital space-occupying lesions was studied in group of 28 patients with a wide range of pathology. The NMR findings in six patients are illustrated. The results of the NMR scans are compared with the information that can be derived from conventional neuroradiologic procedures, including computed tomography. The value of the multiplanar facility of NMR is emphasized. It provides accurate volumetric information and establishes the precise topographical relationships of tumors to normal structures. The muscle cone and the optic nerve can be identified in the axial, coronal, and sagittal planes. Current limitations of the method and possible future developments to improve diagnostic precision are discussed.
Total body sodium by whole body neutron activation in the living subject: further evidence for non-exchangeable sodium pool.
Authors: M. J. Chamberlain, J. H. Fremlin, D. K. Peters, H. Philip
Journal: BMJ (1968)

which included the Radiation Protection Officers of the University and of the United Birmingham Hospitals.The work involving cadavers was done with the per- mission of the Inspector of Anatomy at the Home Office.REFERENCES
Higher Expression of Topoisomerase II Alpha Is an Independent Marker of Increased Risk of Cancer-specific Death in Patients with Clear Cell Renal Cell Carcinoma
Authors: Alexander S. Parker, Jeanette E. Eckel-Passow, Daniel Serie, Tracy Hilton, Mansi Parasramka, Richard W. Joseph, Kevin J. Wu, John C. Cheville, Bradley C. Leibovich
Journal: European Urology (2013)