tbuckley/cabot-search huggingface dataset:
The Midnight Ride of Paul Revere
Authors: M. Therese Southgate
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses
Authors: Richard J O'Connell, Michael R Thon, Stéphane Hacquard, Stefan G Amyotte, Jochen Kleemann, Maria F Torres, Ulrike Damm, Ester A Buiate, Lynn Epstein, Noam Alkan, Janine Altmüller, Lucia Alvarado-Balderrama, Christopher A Bauser, Christian Becker, Bruce W Birren, Zehua Chen, Jaeyoung Choi, Jo Anne Crouch, Jonathan P Duvick, Mark A Farman, Pamela Gan, David Heiman, Bernard Henrissat, Richard J Howard, Mehdi Kabbage, Christian Koch, Barbara Kracher, Yasuyuki Kubo, Audrey D Law, Marc-Henri Lebrun, Yong-Hwan Lee, Itay Miyara, Neil Moore, Ulla Neumann, Karl Nordström, Daniel G Panaccione, Ralph Panstruga, Michael Place, Robert H Proctor, Dov Prusky, Gabriel Rech, Richard Reinhardt, Jeffrey A Rollins, Steve Rounsley, Christopher L Schardl, David C Schwartz, Narmada Shenoy, Ken Shirasu, Usha R Sikhakolli, Kurt Stüber, Serenella A Sukno, James A Sweigard, Yoshitaka Takano, Hiroyuki Takahara, Frances Trail, H Charlotte van der Does, Lars M Voll, Isa Will, Sarah Young, Qiandong Zeng, Jingze Zhang, Shiguo Zhou, Martin B Dickman, Paul Schulze-Lefert, Emiel Ver Loren van Themaat, Li-Jun Ma, Lisa J Vaillancourt
Journal: Nature Genetics (2012)
A Fire Hazard
Authors: H. H. Rohrer
Journal: JAMA (1974)

To the Editor.—  The COMMENTARY (229:1181, 1974) brought forcibly to mind an episode occurring on May 16, 1974, in which large numbers of people were threatened by highly concentrated oxides of nitrogen. A 235 x 48-meter (784 x 160-foot), 80,000-ton-capacity fertilizer warehouse, one third filled with nitrogen-rich commercial fertilizer, caught fire. The frame structure quickly burned to the ground, generating temperatures sufficient to ignite the fertilizer.  The huge plume of orange smoke could be seen for many miles. There would have been an immediate emergency had the wind been from the north. Fortunately it was from the southwest, thus dispersing the smoke over a nonpopulated area.  The fire was reported quickly enough, but it was eight hours before health officials were notified, with another two to three hours before the extreme hazard of the burning contents was fully appreciated. Fire fighting difficulties caused another ten hours to lapse before the
Reduction in Hemoglobin–Oxygen Affinity Results in the Improvement of Exercise Capacity in Mice With Chronic Heart Failure
Authors: Tetsuya Watanabe, Toshihiro Takeda, Shigemiki Omiya, Shungo Hikoso, Osamu Yamaguchi, Yuko Nakano, Yoshiharu Higuchi, Atsuko Nakai, Yusuke Abe, Yayoi Aki-Jin, Masayuki Taniike, Isamu Mizote, Yasushi Matsumura, Takahiko Shimizu, Kazuhiko Nishida, Kiyohiro Imai, Masatsugu Hori, Takuji Shirasawa, Kinya Otsu
Journal: Journal of the American College of Cardiology (2008)
(7) Swollen toe due to epithelioid haemangioma of bone
Authors: C.T.C. Kennedy, P.A. Burton, P. Cook
Journal: British Journal of Dermatology (1990)

Journal Article (7) Swollen toe due to epithelioid haemangioma of bone Get access C.T.C. Kennedy, C.T.C. Kennedy Departments of Dermatology, Bristol Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar P.A. Burton, P.A. Burton Department of Histopathology, Southmead General Hospital, Bristol BS10 5NB Search for other works by this author on: Oxford Academic Google Scholar P. Cook P. Cook Departments of Radiodiagnosis, Bristol Royal Infirmary Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 123, Issue s37, 1 July 1990, Pages 85–89, https://doi.org/10.1111/j.1365-2133.1990.tb04493.x Published: 01 July 1990
Storage of serum in plastic and glass containers may alter the serum concentration of polychlorinated biphenyls.
Authors: Wilfried Karmaus, John F Riebow
Journal: Environmental Health Perspectives (2004)

Valid exposure assessment and biomonitoring of toxicants rely on standardized specimen collection, handling, storage, and measurement. In a study designed to determine organochlorine concentrations in blood samples, we recruited participants from registered anglers in Michigan. After participants were interviewed, blood was collected from study subjects, either at home by a phlebotomist or in a commercial blood-draw station. The phlebotomists stored their samples in glass containers, but without our knowledge, the commercial laboratory transferred the specimens to plastic containers for freezing in its central facility. Samples were analyzed in the Analytical Chemistry Section Laboratory of the Michigan Department of Community Health. This laboratory also provided information on storage in glass (n = 28) versus plastic containers (n = 113). We conducted linear regression analyses to assess factors that may explain the concentrations of polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (DDE), and polybrominated biphenyls (PBBs). Our results indicate that storage of serum in plastic containers altered the total concentrations of PCBs, in particular, the higher chlorinated PCBs (PCB-180 and PCB-199), but not DDE or PBBs. No other characteristics of the samples could explain the higher PCB values (0.75 micro g/L vs. 0.45 micro g/L; p = 0.025) of those stored in plastic containers. The proportion of PCB detects in both subsamples did not differ. Some preceding studies have provided information on whether specimens were stored in glass or plastic containers; however, a number of studies have not. We suggest the initiation of a new review process to determine whether these earlier reports were based on unbiased PCB determinations. We recommend standardizing specimen collection, handling, storage, and measurement, which is particularly necessary for newly emerging analytes.
Lung Cancer in Combined Pulmonary Fibrosis and Emphysema: A Series of 47 Western Patients
Authors: Nicolas Girard, Sylvain Marchand-Adam, Jean-Marc Naccache, Raphael Borie, Thierry Urban, Stéphane Jouneau, Eric Marchand, Anne-Claire Ravel, Lize Kiakouama, Bénédicte Etienne-Mastroianni, Jacques Cadranel, Vincent Cottin, Jean-François Cordier
Journal: Journal of Thoracic Oncology (2014)
Endothelin increases myofilament Ca2+ sensitivity in alpha-toxin-permeabilized rabbit mesenteric artery.
Authors: J Nishimura, S Moreland, H Y Ahn, T Kawase, R S Moreland, C van Breemen
Journal: Circulation Research (1992)

This study was designed to investigate the mechanism of endothelin-1 (ET-1) contractions in Staphylococcus alpha-toxin-permeabilized vascular smooth muscle. Rabbit small mesenteric arteries permeabilized with alpha-toxin were mounted for isometric or isotonic force recording or were processed for determination of myosin light chain (MLC) phosphorylation levels. Addition of 100 nM ET-1 plus 10 microM GTP significantly enhanced myofilament Ca2+ sensitivity as compared with the addition of Ca2+ alone (EC50, 0.47 microM Ca2+ for Ca2+ alone and 0.13 microM Ca2+ for ET-1 plus (GTP). This enhanced sensitivity was reversed by GDP beta S. ET-1-induced contractions were relaxed at a constant [Ca2+] by the addition of 30 microM cAMP or cGMP, demonstrating a direct effect of the cyclic nucleotides on contractile regulation. Inhibition of protein kinase C activity by 100 nM staurosporine relaxed ET-1 plus GTP-induced contractions, and pretreatment with 40 microM chelerythrine inhibited the ET-1 plus GTP increase in force. At 0.32 microM Ca2+, steady-state levels of shortening velocity were not increased by ET-1 plus GTP, although steady-state levels of MLC phosphorylation were significantly enhanced. The ET-1-induced increase in MLC phosphorylation was not altered by changes in [Ca2+], whereas the shortening velocity was Ca2+ dependent, suggesting that the increase MLC phosphorylation level may be the result of protein kinase C, rather than MLC kinase, activation. These results are consistent with the hypothesis that ET-1 increases myofilament Ca2+ sensitivity by a G protein-dependent pathway and subsequent activation of protein kinase C.(ABSTRACT TRUNCATED AT 250 WORDS)
He Lectures at the Heritage Association Dinner
Authors: Jack Coulehan
Journal: Annals of Internal Medicine (2013)

Ad Libitum3 December 2013He Lectures at the Heritage Association DinnerJack Coulehan, MD, MPHJack Coulehan, MD, MPHFrom Setauket, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-11-201312030-00010 Audio Reading - “He Lectures at the Heritage Association Dinner” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "He Lectures at the Heritage Association Dinner," by J. Coulehan. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail of ... Author, Article, and Disclosure InformationAuthors: Jack Coulehan, MD, MPHAffiliations: From Setauket, New York.Current Author Address: Jack Coulehan, MD, MPH, e-mail, [email protected]. PreviousarticleNextarticle Advertisement Audio Reading - “He Lectures at the Heritage Association Dinner” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "He Lectures at the Heritage Association Dinner," by J. Coulehan. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 3 December 2013Volume 159, Issue 11 Page: 779 Keywords Heart Homicide ePublished: 3 December 2013 Issue Published: 3 December 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
Authors: Ann K Daly, Peter T Donaldson, Pallav Bhatnagar, Yufeng Shen, Itsik Pe'er, Aris Floratos, Mark J Daly, David B Goldstein, Sally John, Matthew R Nelson, Julia Graham, B Kevin Park, John F Dillon, William Bernal, Heather J Cordell, Munir Pirmohamed, Guruprasad P Aithal, Christopher P Day
Journal: Nature Genetics (2009)
Anesthesia Awareness and the Bispectral Index
Authors: Michael S. Avidan, Lini Zhang, Beth A. Burnside, Kevin J. Finkel, Adam C. Searleman, Jacqueline A. Selvidge, Leif Saager, Michelle S. Turner, Srikar Rao, Michael Bottros, Charles Hantler, Eric Jacobsohn, Alex S. Evers
Journal: New England Journal of Medicine (2008)

Awareness during anesthesia is a serious complication with potential long-term psychological consequences. Use of the bispectral index (BIS), developed from a processed electroencephalogram, has been reported to decrease the incidence of anesthesia awareness when the BIS value is maintained below 60. In this trial, we sought to determine whether a BIS-based protocol is better than a protocol based on a measurement of end-tidal anesthetic gas (ETAG) for decreasing anesthesia awareness in patients at high risk for this complication.We randomly assigned 2000 patients to BIS-guided anesthesia (target BIS range, 40 to 60) or ETAG-guided anesthesia (target ETAG range, 0.7 to 1.3 minimum alveolar concentration [MAC]). Postoperatively, patients were assessed for anesthesia awareness at three intervals (0 to 24 hours, 24 to 72 hours, and 30 days after extubation).We assessed 967 and 974 patients from the BIS and ETAG groups, respectively. Two cases of definite anesthesia awareness occurred in each group (absolute difference, 0%; 95% confidence interval [CI], -0.56 to 0.57%). The BIS value was greater than 60 in one case of definite anesthesia awareness, and the ETAG concentrations were less than 0.7 MAC in three cases. For all patients, the mean (+/-SD) time-averaged ETAG concentration was 0.81+/-0.25 MAC in the BIS group and 0.82+/-0.23 MAC in the ETAG group (P=0.10; 95% CI for the difference between the BIS and ETAG groups, -0.04 to 0.01 MAC).We did not reproduce the results of previous studies that reported a lower incidence of anesthesia awareness with BIS monitoring, and the use of the BIS protocol was not associated with reduced administration of volatile anesthetic gases. Anesthesia awareness occurred even when BIS values and ETAG concentrations were within the target ranges. Our findings do not support routine BIS monitoring as part of standard practice. (ClinicalTrials.gov number, NCT00281489 [ClinicalTrials.gov].).
Secret government revisited
Authors: M. McKee
Journal: BMJ (1999)

Three years ago Lang and I argued in the BMJ the case for a freedom of information act in the United Kingdom.1 Citing a series of examples in which the public had lost confidence in the health advice given by government, we contended that a much greater openness was required if public trust was to be restored. Last month the British government unveiled its much heralded proposals for a freedom of information act for the United Kingdom. How does it match up to the expectations?

Since we wrote about it three years ago, the case for greater openness has strengthened considerably. The revelations emerging from the inquiry into bovine spongiform encephalopathy,2 the fiasco surrounding tobacco sponsorship of Formula One racing,3 and, most recently, the disclosure that the government is seeking to influence the media coverage of genetically modified food are only the most obvious examples of the need for action.4 And the benefits of disclosure are also becoming clearer. British campaigners on safety and the environment have made increasing use of the United …
Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction
Authors: Naiara Akizu, Vincent Cantagrel, Maha S Zaki, Lihadh Al-Gazali, Xin Wang, Rasim Ozgur Rosti, Esra Dikoglu, Antoinette Bernabe Gelot, Basak Rosti, Keith K Vaux, Eric M Scott, Jennifer L Silhavy, Jana Schroth, Brett Copeland, Ashleigh E Schaffer, Philip L S M Gordts, Jeffrey D Esko, Matthew D Buschman, Seth J Field, Gennaro Napolitano, Ghada M Abdel-Salam, R Koksal Ozgul, Mahmut Samil Sagıroglu, Matloob Azam, Samira Ismail, Mona Aglan, Laila Selim, Iman G Mahmoud, Sawsan Abdel-Hadi, Amera El Badawy, Abdelrahim A Sadek, Faezeh Mojahedi, Hulya Kayserili, Amira Masri, Laila Bastaki, Samia Temtamy, Ulrich Müller, Isabelle Desguerre, Jean-Laurent Casanova, Ali Dursun, Murat Gunel, Stacey B Gabriel, Pascale de Lonlay, Joseph G Gleeson
Journal: Nature Genetics (2015)
Abstract 5658: Engineered Salmonella effectively produce and preferentially deliver bacterial cytotoxins to solid tumors
Authors: Adam T. St. Jean, Charles A. Swofford, Zachary J. Brentzel, Neil S. Forbes
Journal: Cancer Research (2012)

Abstract To effectively treat cancer, therapeutics must specifically target tumor tissue and impart minimal toxicity to healthy tissues. Bacterial toxins, such as Pseudomonas aeruginosa Exotoxin A (PEA) and Staphylococcus aureus Alpha-Hemolysin (SAH), are highly cytotoxic and are promising moieties for cancer treatment. Due to their high toxicity and non-specificity towards all cells types, systemic effects limit their effectiveness as a therapeutic. While efforts have been made to impart cancer-cell specificity to these potent molecules, especially through immunotoxin technology, systemic toxicities still prove to be a challenge. Genetically engineered bacteria, such as Salmonella typhimurium, are known to target cancer by preferential accumulation within tumors and thus can be exploited as tumor-specific drug delivery vectors. By using cellular engineering techniques, the genetic machinery of bacteria can be used to produce exogenous bacterial toxins in situ. In addition to the specificity of bacterial accumulation, inducible promoter systems such as the arabinose-inducible system can be used to minimize systemic toxin levels by controlling the timing of protein expression. By coupling these strategies, we have been able to develop an effective bacterial therapy for targeted tumor treatment. PEA and SAH expressed in Salmonella under the PBAD promoter was secreted into the culture medium following arabinose induction. Monolayer cultures of MCF7 human breast carcinoma cells treated with secreted PEA and SAH for three days were depleted by 82% and 99%, respectively. Mechanism of delivery studies in a murine tumor model showed co-localization of salmonella, toxins and cell death within tumors following arabinose induction, while minimizing the localization of toxins to the healthy organs. Survival studies indicate that bacterial delivery of PEA and SAH can minimize systemic toxicities while decreasing tumor growth and increasing survival. Overall, these data indicate that by using bacteria to produce toxins in situ, we were able to overcome the delivery challenges inherent with non-specific toxin moieties and create a highly efficacious drug delivery system for use in the treatment of solid tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5658. doi:1538-7445.AM2012-5658
Detection of Carotid Stenosis by Physicial Examination
Authors: Terrence J. Coyle
Journal: JAMA (1994)

To the Editor.  —The article by Dr Sauve and colleagues 1 on assessing clinical significance of carotid bruits failed to mention the value of ophthalmodynamometry to grossly estimate the severity of carotid stenosis.  The optic nerve is observed with an ophthalmoscope. Pressure with the index finger is exerted against the sclera through the lid, and the central retinal artery is monitored for pulsation. If pulsation of the artery occurs (collapse at diastole, expansion at systole) with minimal pressure against the globe, the blood supply to the ophthalmic artery from the carotid system may be compromised. An ophthalmodynamometer provides more precise determination; however, with severe compromise of blood flow, it is inaccurate because the pressure may be too low to measure. Indeed, some patients with a pending central retinal artery occlusion on the basis of stenosis can exhibit spontaneous artery pulsations when moved from a supine to an upright position.  To
Fluoxymesterone Therapy in Advanced Breast Cancer
Authors: B. J. Kennedy
Journal: New England Journal of Medicine (1958)

ANDROGENIC hormones have been effectively employed in the therapy of advanced breast cancer. Objective improvement occurs in approximately 25 per cent of patients with osseous metastases, with a lower rate of response in patients with soft-tissue lesions.1 Since the effects of castration in premenopausal women are far superior to those of androgenic therapy, the male hormones have been employed primarily for women of postmenopausal age. A continuing search for more effective androgenic compounds is under way. Testosterone propionate, administered intramuscularly in three divided doses of 150 to 300 mg. weekly, has become the standard agent in the evaluation by comparison . . .
Preferential Closed-State Inactivation of Neuronal Calcium Channels
Authors: Parag G Patil, David L Brody, David T Yue
Journal: Neuron (1998)

We have investigated the inactivation mechanism of neuronal N-, P/Q-, and R-type calcium channels. Although channels inactivate slowly during square-pulse depolarization, as observed previously, we now find that they inactivate profoundly during a train of action potential (AP) waveforms. The apparent paradox arises from a voltage-dependent mechanism in which channels inactivate preferentially from intermediate closed states along the activation pathway. Inactivation can therefore extend beyond the brief duration of AP waveforms to continue between spikes, as the channel undergoes repetitive cycles of activation and deactivation. The extent of inactivation during a train is strongly affected by the subunit composition of channels. Preferential closed-state inactivation of neuronal calcium channels could produce widely variable depression of Ca2+ entry during a train of APs.
Target centred medicine: why it is essential to cheat
Authors: A. N Bamji
Journal: BMJ (2003)

EDITOR—D'Sa et al are wrong to believe that only patients are cheated by target centred medicine1: we are all cheated, including any gullible members of the public (or politicians) who believe the figures.

For various reasons we have not put our outpatient bookings for our rehabilitation multidisciplinary clinic through the hospital's patient administration system—until we realised that our …
Enterically transmitted non-A, non-B hepatitis: Recovery of virus–like particles from an epidemic in south delhi and transmission studies in rhesus monkeys
Authors: Subrat K. Panda, Rakesh Datta, Jagjit Kaur, Arie J. Zuckerman, Nabeen C. Nayak
Journal: Hepatology (1989)

An epidemic of viral hepatitis, serologically characterized as due to non-A, non-B hepatitis, occurred in a village of South Delhi, India, in December, 1986, through January, 1987. Water contaminated with fecal matter was the apparent source of infection. Disease-associated virus-like particles were detected by immune electron microscopy in the feces of three patients within 5 days of illness. The virus-like particles were agglutinated by autologous acute-phase serum but not by convalescent serum. Rhesus monkeys inoculated with particle-containing fecal suspensions developed biochemical and morphologic features of acute, self-limited hepatitis. The findings in the present study and in earlier investigations of sporadic non-A, non-B hepatitis suggest that (i) the epidemic form and a proportion of sporadic cases of this infection in India may be related, both being enterically transmitted and associated with infection by a 27-to 32-nm virus-like particle, (ii) antibody responses to this virus occur early in disease and are transient and (iii) the rhesus monkey may prove to be a suitable model for studies of epidemic non-A, non-B hepatitis.