tbuckley/cabot-search huggingface dataset:
Calcium antagonists and adenine nucleotide metabolism in rat heart
Authors: S. V NIGDIKAR, J. BOWDITCH, J. W DOW
Journal: Cardiovascular Research (1986)

Attempts to identify mechanisms by which calcium antagonists might influence intracellular metabolism have not yet yielded conclusive findings. In this study bepridil, verapamil, nifedipine, and nisoldipine were found to have no influence on the rate of rat heart myosin adenosine triphosphatase or the calcium dependence of myofibrillar adenosine triphosphatase. None of these calcium antagonists alters the rate of reaction of any of the adenine nucleotide catabolic or adenosine salvage enzymes, adenylate kinase, creatine kinase, adenosine kinase, adenosine deaminase, or 5' nucleotidase, in extracts of rat heart. All four compounds, however, reduced, apparently in a non-specific manner, the rate of uptake of adenosine by myocytes isolated from rat heart. It is concluded that calcium antagonists may, through intercalation with the sarcolemmal membrane, inhibit efflux of adenosine formed by catabolism of adenine nucleotides in ischaemic myocytes. This might offer therapeutic advantage since the intracellular concentration of adenosine would thereby be increased, allowing an increased rate of incorporation of adenosine into the adenosine triphosphate pool in reoxygenated myocardium.
Viruses vs Superbugs: A Solution to the Antibiotic Crisis?
Authors: Mikael Skurnik
Journal: JAMA (2007)

Having recently written a short review of phage therapy,1 I was eager to read Viruses vs Superbugs, by Swiss science journalist Thomas Häusler. I have a longstanding research interest in Yersinia bacteriophages and have followed developments in phage therapy for several years.
Diagnosis and management of headache in adults: summary of SIGN guideline
Authors: C W Duncan, D P B Watson, A Stein
Journal: BMJ (2008)

Headache is common and has a lifetime prevalence of over 90% in the United Kingdom.1 It accounts for 4.4% of consultations in primary care2 and 30% of neurology outpatient consultations.3 4 Healthcare professionals find diagnosis and management of headache difficult and they worry about missing rare, serious causes.2 5 This article summarises the most recent recommendations from the Scottish Intercollegiate Guidelines Network (SIGN) on the diagnosis and management of headache in adults.6 SIGN recommendations are based on systematic reviews of best available evidence. The strength of the evidence is graded as A, B, C, or D (figure⇓), but the grading does not reflect the clinical importance of the recommendations. Recommended best practice (“good practice points”) based on the clinical experience of the guideline development group is also indicated (as GPP). Explanation of SIGN grades of recommendations. ### History and examination A good history is the key to diagnosis. Examination is usually normal in patients with primary headache, such as migraine, tension-type headache, and cluster headache.
Contrast Media for ERCP
Authors: A. Rambow, M. Staritz, K.-H. Meyer zum Büschenfelde
Journal: Endoscopy (1988)

See also: A Randomised, Prospective Study Comparing Two Contrast Media in ERCPEndoscopy 1987; 19(05): 201-202DOI: 10.1055/s-2007-1013018 See also: Controversy Concerning Contrast Media for ERCPEndoscopy 1989; 21(03): 158-158DOI: 10.1055/s-2007-1012931
Sustained Release of Erythropoietin Using Biodegradable Gelatin Hydrogel Microspheres Persistently Improves Lower Leg Ischemia
Authors: Longhu Li, Hideshi Okada, Genzou Takemura, Masayasu Esaki, Hiroyuki Kobayashi, Hiromitsu Kanamori, Itta Kawamura, Rumi Maruyama, Takako Fujiwara, Hisayoshi Fujiwara, Yasuhiko Tabata, Shinya Minatoguchi
Journal: Journal of the American College of Cardiology (2009)
The Management of the Third Stage of Labour
Authors: Wm. J. Smyly
Journal: BMJ (1885)

and, finally, the divided ends of the bowel should be secured to the margins of the abdominal wound, and an artificial anuis established.This artificial anus can, at a future time, be closed by the now familiar resection operation, and the loop, so united, retuirned into the abdomen.The practice of uniting the divided ends of the bowel, immediately after the resection, is, for many very pressing reasons, to be condemned.It may be well to point out that neither enterotomy nor colotomy can lay claim to be of value in the treatment of non-exceptional cases of in- tussusception.These operations certainly relieve the obstruction; but they leave in the abdomen an invaginated intestine, inwhich the process of inflammation and gangrene can still advance.The operation of resection has now had an extended trial.Reichel, in a recent paper, collected one hundred and twenty-one cases in which the procedure was carried out.The technical details of the operation have becn elaborated, and this method of treatment bids fair to play an important part in the fuiture of abdominal surgery.
Exacerbation of Salmonella Enteritis Due to Ampicillin
Authors: Samuel L. Rosenthal
Journal: New England Journal of Medicine (1969)

ALTERATION of the normal intestinal flora with antibacterial agents may have harmful results. Antibiotic therapy has been implicated in the pathogenesis of pseudomembranous enterocolitis1 and enteric candidiasis.2 A patient with severe diarrhea was recently observed who had been given ampicillin as a symptom-free carrier of salmonella. Administration of the drug apparently led to suppression of the normal intestinal flora and to the unrestrained growth of a salmonella species that was resistant to ampicillin.Case ReportJ.S., an 18-year-old boy, was admitted to Syracuse City Hospital on March 20, 1968, because of abdominal cramps and bloody diarrhea. Between March 5 and . . .
Age-related mutations associated with clonal hematopoietic expansion and malignancies
Authors: Mingchao Xie, Charles Lu, Jiayin Wang, Michael D McLellan, Kimberly J Johnson, Michael C Wendl, Joshua F McMichael, Heather K Schmidt, Venkata Yellapantula, Christopher A Miller, Bradley A Ozenberger, John S Welch, Daniel C Link, Matthew J Walter, Elaine R Mardis, John F Dipersio, Feng Chen, Richard K Wilson, Timothy J Ley, Li Ding
Journal: Nature Medicine (2014)
The 2013 Lung Allocation Controversy
Authors: Stephen G. Harvey
Journal: Annals of Internal Medicine (2013)

LettersDecember 3, 2013The 2013 Lung Allocation ControversyStephen G. Harvey, JDStephen G. Harvey, JDFrom Pepper Hamilton LLP, Philadelphia, Pennsylvania.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-11-201312030-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Halpern (1) refers to the temporary restraining orders issued on 5 and 6 June 2013 by Judge Michael M. Baylson, a federal judge in Philadelphia, as “a troubling precedent,” “circumvention of due process,” and “legal wrongs.” He says that the temporary restraining orders suggest “either failure to recognize that preferential treatment for some recipients will adversely affect others (who may not be much older than 12) or that the court considered these 2 children's lives more valuable than others.”His assertions are incorrect. I assume that he is aware that a specific federal regulation, a binding law, ...Reference1. Halpern SD. Turning wrong into right: the 2013 lung allocation controversy. Ann Intern Med. 2013;159:358-9 LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Stephen G. Harvey, JDAffiliations: From Pepper Hamilton LLP, Philadelphia, Pennsylvania.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L13-1069. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTurning Wrong Into Right: The 2013 Lung Allocation Controversy Scott D. Halpern The 2013 Lung Allocation Controversy Scott D. Halpern Metrics December 3, 2013Volume 159, Issue 11Page: 794KeywordsAdultsChildrenHabitsHealth careLung transplantationLungsMedical servicesTransplantationYoung adults ePublished: 3 December 2013 Issue Published: December 3, 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Sequential processing of “items” and “relations”
Authors: Dave G. Mumby
Journal: Behavioral and Brain Sciences (1996)

Abstract Eichenbaum et al. (1994a) hypothesized that perceptually distinct items and the relations among them are processed sequentially by the parahippocampal region and the hippocampal formation, respectively. Predictions based solely on their model's sequential-processing feature might prove easier to disconfirm than those based on its representational features. Two such predictions are discussed: (1) double dissociations should be impossible following hippocampal vs. parahippocampal lesions, and (2) hippocampal lesions should not exacerbate impairments that follow complete parahippocampal lesions.
Aphasia in Adults: Diagnosis, Prognosis, and Treatment
Authors: John F. Simpson
Journal: JAMA (1965)

The authors of this book are among the leaders in comprehensive language-testing in aphasics, an approach forming the basis for much of the current literature. The data obtained from the application of their own test are presented, together with a valuable historical review and survey of current research.  Two important principles have been confirmed, firstly, that in a given aphasic patient, patterns of error are consistent, and secondly, that in any aphasic all modalities of language are impaired. Statistical analysis of recurring patterns of language impairment has resulted in yet another classification of aphasia, with categories differing in specific perceptual, sensorimotor, and dysarthric components. The authors recognize that statistical evaluations of human illness, with their connotation of precision, cannot always be applied to the individual patient, but they present data which appear consistent and reproducible. Although the imprecise classical terminology is abandoned, that of the authors is perhaps equally unwieldy.
Abstract LB-84: Mutant p53 enhances the metastatic potential of ovarian cancer cells
Authors: Ji-Hye Ahn, Jong-Gyu Lee, Jung-Hye Choi
Journal: Cancer Research (2014)

Abstract Missense-mutations of TP53 resulting in accumulation of mutant proteins are very frequent in human cancer including ovarian cancer. Aggressive ovarian cancer is characterized by a peritoneal metastasis which involves the adhesion, migration, and invasion of tumor cells to the peritoneal cavity. In the present study, we investigated the effect of p53 GOF mutation (p53R248) on the metastatic potential of human ovarian cancer cells. We found that forced overexpression of p53R248 significantly increased adhesion to mesothelial cell Met5A, migration, and invasion in p53-null SKOV-3 cells. Conversely, knockdown of mutant p53 using siRNA significantly compromised p53R248-induced cell adhesion, migration, and invasion. Microarray analysis revealed that several metastasis-related genes including integrins and S1PR1(Sphingosine-1-phosphate receptor 1), and certain signaling pathway including PI3K/AKT were markedly up-regulated in p53R248 transfectant SKOV-3R248 cells. Inhibition of PI3K/Akt signaling using specific inhibitor significantly attenuated p53R248-mediated mesothelial cell adhesion, migration, and invasion. These finding show for the first time that mutant p53R248 may exert gain-of-function activity to regulate metastasis-related gene expression and the PI3K/Akt singling pathway in ovarian cancer. Citation Format: Ji-Hye Ahn, Jong-Gyu Lee, Jung-Hye Choi. Mutant p53 enhances the metastatic potential of ovarian cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-84. doi:10.1158/1538-7445.AM2014-LB-84
409 Differential mechanism of interferon-induced and spontaneous clearance of hepatitis C virus infection
Authors: D KAPLAN, K SUGIMOTO, F IKEDA, J STADANLICK, K SHETTY, K REDDY, B RENSMAN, M VALIGA, K CHANG
Journal: Hepatology (2003)

Synthetic 4, 5-didehydro GGA (geranylgeranoic acid), a potent ligand both for cellular retinoic acid-binding protien and for nuclear retinoid receptors, induced apoptosis in human hepatoma-derived cell line HuH-7 but not in primary hepatocytes, although all-transor 9-cisretinoic acid did not induce any growth inhibition. Either exogenous transforming growth factor-α (TGFα) or epidermal growth factor (EGF) prevented the cells from apoptosis in the presence of 4, 5-didehydro GGA, but hepatocyte growth factor, insulin-like growth factor-II, insulin or triiodothyronine was essentially inactive. 4, 5-Didehydro GGA down-regulated the cellular levels of antibody induced apoptosis in HuH-7 cells without using the acid. Taken together, the present study strongly suggests that 4, 5-didehydro GGA induced apoptosis in HuH-7 cells through the destruction of autocrine loop consisting of TGFα and EGF receptor, due to the down-regulation of TGFα gene expression.
Reducing Serum Phosphorus Concentration in Patients With End-Stage Renal Disease
Authors: Antonio Alberto Lopes
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
BOOT HEELS AS A CAUSE OF FLAT-FOOT, SOLDIER'S HEART, MYALGIA, Etc
Authors: S. D. Fairweather
Journal: BMJ (1918)

A device was employed at the operation whlichl m-ay vell serve as an adjunct to the ingesi%ous and effective technique o£ Haines.2I cannot find in the literature a reference to this metlhod, and.as any plan which will strengthen the abdominal wall in these extreme cases may prove lhelpful,
Percutaneous transfemoral lumbar aortography as an outpatient procedure.
Authors: P J Shaw, J F Reidy, M R Salari
Journal: BMJ (1983)

Cases 3 and 4-A 70 year old man and his 60 year old wife were found dead by the police in a bungalow adjoining those of the patients in cases 1 and 2. It was reported that the couple had previously and simultaneously complained of headache, nausea, and dizziness.Their skin and mucosa showed pink discoloration.At necropsy the heart and great vessels were engorged by blood whose carbon monoxide saturation was 75 %O/.Multiple pinpoint haemorrhages were observed in the cut surfaces of their oedematous brains.Case 5-The 72 year old husband of the patient in case 2 had been admitted to hospital in a neighbouring town three days before his wife and with a similar presentation.Carbon monoxide analysis was not performed.Though semiconscious and showing periodic respirations on admission, he made a full neurological recovery.A retired miner, he realised in retrospect that the prodromal symptoms that he had suffered had resembled those experienced years earlier when he was exposed to carbon monoxide.Case 6-A 71 year old woman, who had been a previous occupant of the bungalow in which the patients in cases 3 and 4 were found, had experienced intermittent headaches and dizziness while living there.Her granddaughter had been similarly affected at each visit to the bungalow.Further inquiries ordered by the coroner indicated that the gas fired, ducted air central heating system in each bungalow was functioning satis- factorily with no evidence of incomplete combustion of natural gas, which contains no carbon monoxide.More detailed investigation showed that carbon monoxide was inter- mittently present at the points where service pipes and cables entered the bungalows.The concentration of carbon monoxide increased as the atmospheric pressure fell, and its source was traced to an old mine shaft some distance from the bungalows and sunk in 1780.Coal mining had stopped in 1933, and the shaft had been filled with rubble.Industrial waste had recently been burned outside a nearby factory, however, and the fire had spread to the materials in the mine shaft.Analysis of the gases in the mine confirmed that carbon monoxide was present.This was seeping down the shaft and through fissures and faults in the porous sandstone underlying the area before passing up intermittently into the bungalows.The shaft was reopened and the gas extracted before refilling.The bungalows were demolished.
BEHAVIOR OF BIOMARKERS LINKING INFLAMMATION AND THROMBOSIS IN THE INFARCT-RELATED CORONARY ARTERY AND SYSTEMIC CIRCULATION AFTER PRIMARY PERCUTANEOUS CORONARY INTERVENTION FOR THE TREATMENT OF ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
Authors: Tomomi Koizumi, Tetsuo Yamasaki, Shinichiro Iida, Toshihiko Kikutani, Shigeyuki Nishimura, Nobuyuki Komiyama
Journal: Journal of the American College of Cardiology (2010)
DUPLICATION OF THE RECTUM CONTAINING GASTRIC MUCOSA
Authors: J. M. Stockman
Journal: JAMA (1960)

Duplications may occur in any portion of the alimentary tract from the base of the tongue to the anus. These may be elongated, tubular structures duplicating large or small portions of the alimentary canal. They are seen also as cystic structures intimately attached to the alimentary system. Finally, they may take the form of giant diverticula with free connection to some part of the bowel. However, the inclusive term "duplication of the alimentary tract" is applied to all these anomalies. Furthermore, a true duplication must contain a coat of smooth muscle, connect with some portion of the alimentary canal, and be lined with alimentary tract mucous membrane.<sup>1</sup>This condition should not be confused with Meckel's diverticulum, which is an entirely different entity with a distinct embryonic derivation. The relatively small number of duplications reported in the literature would suggest that this represents an uncommon condition.<sup>2</sup>Duplications are seen
When Is AIDS Communicable?
Authors: Hans H. Neumann
Journal: JAMA (1984)

To the Editor.—  In describing a working hypothesis, Klatzman of the French acquired immune deficiency syndrome (AIDS) working group states that it probably takes multiple attacks by a retrovirus to devastate the immune system. 1 This implies that the actual AIDS infections (retroviral or other) are acute episodes of limited duration. This is speculative, but reasonably so, and there is evidence to support such a concept.  Thus far, we have no documented case of AIDS that has been acquired through direct, close contact with a patient known to be symptomatic with opportunistic infections. The various secondary infections that cause the downward slide of the victim's condition and show the dramatic picture of the AIDS cases are not a danger to healthy contacts, even though the public, including prison guards, policemen, and undertakers, may understandably but needlessly panic.  The AIDS infection itself, which damaged those cells linked to immunity, may have
Neural Correlates of Impaired Cognitive-Behavioral Flexibility in Anorexia Nervosa
Authors: Arne Zastrow, Stefan Kaiser,, Christoph Stippich, Stephan Walther, Wolfgang Herzog, Kate Tchanturia, Aysenil Belger, Matthias Weisbrod, Janet Treasure, Hans-Christoph Friederich
Journal: American Journal of Psychiatry (2009)

Impaired cognitive-behavioral flexibility is regarded as a trait marker in anorexia nervosa patients. The authors sought to investigate the neural correlates of this deficit in executive functioning in anorexia nervosa.Fifteen women with anorexia nervosa and 15 age-matched healthy comparison women underwent event-related functional MRI while performing a target-detection task. The task distinguished between shifts in behavioral response and shifts in cognitive set. It involved infrequent target and non-target distractor stimuli embedded in a sequence of prepotent standard stimuli.Relative to comparison subjects, anorexia nervosa patients showed a significantly higher error rate in behavioral response shifting, independent of whether those runs also involved cognitive set shifting. During behavioral response shifting, patients showed reduced activation in the left and right thalamus, ventral striatum, anterior cingulate cortex, sensorimotor brain regions, and cerebellum that differed significantly from the comparison group but showed dominant activation in frontal and parietal brain regions. These differential activations in patients and comparison subjects were specific to shifts in behavioral response: except for thalamic activation, they were not observed in response to non-target distractor trials that required no alteration in behavioral response.Impaired behavioral response shifting in anorexia nervosa seems to be associated with hypoactivation in the ventral anterior cingulate-striato-thalamic loop that is involved in motivation-related behavior. In contrast, anorexia nervosa patients showed predominant activation of frontoparietal networks that is indicative of effortful and supervisory cognitive control during task performance.
Abstract IA1: Mining the TCGA
Authors: Douglas A. Levine
Journal: Clinical Cancer Research (2013)

Abstract The Cancer Genome Atlas (TCGA) has recently completed its first formal analysis of the genomic and clinical data from the ovarian carcinoma project. This analysis has confirmed previous knowledge and discovered new insights into this challenging disease. Now is the time for the research community to take hold of this high-quality, robust data set and apply it to translational and basic biologic questions. This session will review the nuts and bolts of The Cancer Genome Atlas comprehensive genomic profiling projects with special emphasis on the completed ovarian project. The sample inclusion criteria, clinical data, and molecular platforms will be reviewed in detail. The TCGA biospecimens pipeline will be discussed. Numerous analytical tools for individuals to download raw data and use previously processed data will be provided. Case studies of individual research projects that use TCGA data will be examined. This session will be useful for any scientists, surgeons, or physicians who are interested in learning more about the NIH-sponsored TCGA project. This session will also be beneficial for individuals interested in figuring out how to practically use the large volumes of data generated by TCGA to enhance ongoing and planned research projects. The goal of this session is to demonstrate how TCGA data can serve as a reliable resource for the greater research community. Citation Format: Douglas A. Levine. Mining the TCGA. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr IA1.