tbuckley/cabot-search huggingface dataset:
Protein Profiles of Bronchoalveolar Lavage Fluid from Patients with Pulmonary Sarcoidosis
Authors: Eva Kriegova, Christian Melle, Vitezslav Kolek, Beata Hutyrova, Frantisek Mrazek, Annett Bleul, Roland M. du Bois, Ferdinand von Eggeling, Martin Petrek
Journal: American Journal of Respiratory and Critical Care Medicine (2006)

Pulmonary sarcoidosis is a multisystem granulomatous disease with various clinical phenotypes. So far, there has been little information on protein patterns (PPs) of bronchoalveolar lavage fluid (BALF) from patients with sarcoidosis and no data are available on PPs in clinical disease subtypes.To investigate the PP of BALF from patients with pulmonary sarcoidosis, to evaluate whether PPs reflect disease course as assessed by chest X-ray (CXR), and to compare PPs between patients with/without Löfgren's syndrome.Surface-enhanced laser desorption/ionization-time-of-flight mass spectroscopy was applied to investigate PPs in unconcentrated BALF from 65 patients (CXR stage I, n = 32; CXR stage II, n = 22, CXR stage III, n = 11) and 23 healthy control subjects. The Mann-Whitney U test was used to detect differentially expressed protein peaks. After reversed-phase fractionation, peptide fingerprint mapping and immunodepletion were used to identify deregulated (up-regulated or down-regulated) proteins.Forty differentially expressed protein entities (2.75-185.62 kD) were detected in patients with pulmonary sarcoidosis versus control subjects (p < 0.05). Whereas 13 peaks (33%) were present across all CXR stages, 27 (67%) were specific for particular CXR stages. Comparison of PPs between CXR stage I patients with or without Löfgren's syndrome revealed 25 differentially expressed peaks. The total number of deregulated peaks and also of those associated with sarcoidosis as a whole were markedly lower in patients with Löfgren's syndrome in comparison with other sarcoid phenotypes. Human serum albumin, alpha1-antitrypsin, and protocadherin-2 precursor were identified from sarcoidosis-associated PP.Surface-enhanced laser desorption/ionization-time-of-flight mass spectroscopy enables determination of protein patterns in sarcoid BALF and allows detection of protein patterns linked to a particular disease course.
New Approaches but the Same Flaws in the Search for Prognostic Signatures
Authors: Ramon Salazar, Josep Tabernero
Journal: Clinical Cancer Research (2014)

A six-gene prognostic colorectal cancer hypoxia score was generated from expression data from in vitro experiments and microarray datasets and was validated in two distinct patient cohorts. The approach followed by the authors is original and biologically sound but could be limited by potential biases and other methodologic limitations.
Letter: Intrathoracic foregut cysts.
Authors: J Miles
Journal: BMJ (1974)

formed first in patients with massive upper gastrointestinal haemorrhage.If this is un- successful in locating the bleeding point, then arteriography should follow.Vaso- constricting drugs may then be infused if the bleeding site is demonstrated.This may be either the definitive treatment or may allow the patient to undergo surgery in a more stable condition.Those patients in whom stress ulcers6 or varices can be domonstrated by endoscopy are particularly suitable candidates for selective vaso- constrictor infusions if other medical methods fail, since surgery is particularly hazardous in these patients.The performance of these procedures is dependent upon the availability of trained radiologists and technicians and the proper facilities.These requirements are becoming more easily met and are within the reach of most larger hospitals.We feel that the present place and future potential of angio- graphy in gastrointestinal bleeding need to be emphasized.-Weare, etc.,
Mitochondrial toxicity of phthalate esters.
Authors: R L Melnick, C M Schiller
Journal: Environmental Health Perspectives (1982)

The effects of mono- and dibutyl phthalate and mono- and di(2-ethylhexyl) phthalate on energy-dependent K+ uptake, respiration rates, and succinate cytochrome c reductase activities of isolated rat liver mitochondria were evaluated. The energy-coupling processes, active K+ transport and oxidative phosphorylation, were affected most by di-n-butyl phthalate and mono(2-ethylhexyl) phthalate. Mono-n-butyl phthalate had a moderate effect on energy coupling and di(2-ethylhexyl) phthalate had no apparent effect. The potency of inhibition of succinate cytochrome c reductase activity was mono(2-ethylhexyl) phthalate greater than di-n-butyl phthalate greater than mono-n-butyl phthalate = di(2-ethylhexyl) phthalate. It is concluded that phthalate esters affect mitochondrial activities by altering the permeability properties of the inner membrane and by inhibiting succinate dehydrogenase activity.
A RECEPTOR FOR ANTIBODY ON B LYMPHOCYTES
Authors: A. Basten, N. L. Warner, T. Mandel
Journal: The Journal of Experimental Medicine (1972)

Binding of antibody to the surface of B lymphocytes was shown to involve the Fc piece of the immunoglobulin molecule. This property was not shared equally by all immunoglobulin classes as revealed by direct binding and inhibition studies. Total IgG globulin was found to label cells more heavily than IgM, and IgG1-containing fractions more heavily than IgG2 fractions lacking IgG1. The ability of various purified myeloma proteins to inhibit attachment of antibody to B cells was examined. Pretreatment of B cells with excess IgG(2a), IgA, or light chain proteins failed to inhibit, whereas IgG1 proteins and to a lesser extent Ig(2b) and IgM proteins at the same concentrations did so. At lower protein concentrations, IgG1 myeloma protein alone retained the capacity to inhibit binding. The conclusion was reached that the receptor on B cells for antibody has a marked predilection for the IgG1 class. Although IgM and IgG(2b) antibody may bind, they do so with lower avidity and probably in insignificant amounts if IgG1 antibody is present in excess. No evidence was found to implicate complement in the binding process. For example, heat-inactivated sera at high dilution retained the ability to label B cells, while the use of purified low molecular weight anticomplementary factor, a potent inhibitor of C'3, did not interfere with the formation of the bond between antibody and cell surface. The failure of anti-mouse immunoglobulin F(ab)'(2) fragments to prevent access of antibody to B cells implied that the antibody-binding receptor and antigen-binding (immunoglobulin) receptor are discrete entities on the B cell membrane. Despite this, a marked similarity between their surface distribution was observed on electron microscopy. The antibody-binding receptor was shown to be a marker for mature B cells. It did not appear to be present on hematopoietic precursor stem cells and was lost during differentiation to antibody-forming cells.
TETANUS FOLLOWING VACCINATION
Authors: A. H. CHURCHILL
Journal: JAMA (1906)

<h3>Patient.</h3> —E. M. B., aged 5½ years, female, in perfect health, living in the country on a farm, was vaccinated Jan. 11, 1906, on left arm with P. D. &amp; Co.'s vaccine from tube. Antiseptic precautions were taken. <h3>History of Disease.</h3> —The child was not seen again until January 30, when the following history was obtained: The arm had been but slightly swollen and the child had felt well during the entire time since vaccination. She got up on the morning of January 30, apparently well, sat at table, and ate some breakfast. She seemed to have slight indisposition during the morning, but at noon she drank coffee and milk. During the afternoon the mother said the child wished to lie down and that she noticed some stiffness of the neck. <h3>Examination.</h3> —I saw the child at 6:30 p. m. and found some rigidity of the left arm, and considerable
End-stage Renal Disease in African-American and White Men
Authors: Michael J. Klag
Journal: JAMA (1997)

To determine reasons for the 4-fold higher incidence of treated end-stage renal disease (ESRD) in African-American men compared with white men.Prospective study.Men screened in 1973 through 1975 for entry into the Multiple Risk Factor Intervention Trial (MRFIT).A total of 332544 men (300645 white, 20222 African American, and 11677 other ethnic groups) aged 35 to 57 years.Incidence of ESRD assessed through 1990 using the Health Care Financing Administration national ESRD treatment registry and by surveillance for death from renal disease from data of the National Death Index and the Social Security Administration.Over a mean follow-up of 16 years, age-adjusted ESRD incidence was 13.90 per 100000 person-years in white men and 44.22 per 100000 person-years in African-American men. Higher blood pressure and lower socioeconomic status were associated with higher incidence of ESRD in both ethnic groups. With adjustment for baseline age, systolic blood pressure, number of cigarettes smoked, previous myocardial infarction, diabetes, income, and serum cholesterol level, relative risk of ESRD in African-American men compared with white men was reduced from 3.20 to 1.87 (95% confidence interval, 1.47-2.39). Both higher systolic blood pressure and lower income in African-American men as compared with white men were particularly related to this reduced relative risk. Results were similar when hypertensive ESRD was used as the outcome.Both higher blood pressure and lower income are associated with a higher incidence of ESRD in both white and African-American men. Disparities in blood pressure and socioeconomic status relate importantly to the excess risk of ESRD in African-American men compared with white men.
The Music and the Medicine
Authors: Name Withheld by Request
Journal: JAMA (1982)

The harmonica sticking out of his lab coat pocket suggested that an unusual physician was walking into the hospital examining room. His slightly stooped shoulders made his 6-ft frame appear slightly shorter, and the hairline of his brown, curly hair, flecked with gray, was receding. Heavy, black-and-silver-rimmed glasses framed his green eyes, and the scars of teenage acne and the wrinkles of 50 years lined his face. The breast pocket of his stiffly starched white coat bulged with an assortment of pens and pencils, a penlight, several tongue blades, and the harmonica. As he greeted the elderly lady on the examining table, his hands commanded attention. Their wide span dwarfed the patient's in a firm but reassuring handshake. Huge veins were outlined on the backs of these hairy hands. The fingernails were clean and clipped short. As he asked her how she felt, he discreetly pulled down the sheet, lifted
Subjective Findings-Reply
Authors: W. Keith C. Morgan
Journal: JAMA (1976)

Dr Halliday certainly has a point, and I tend to agree that the phrase "subjective findings" is somewhat ambiguous. Since I profess to be a bit of a purist in regard to the use of the English language, I can only add that it is a question of the "biter being bit." Nonetheless, it is necessary to point out that many persons do use the term "subjective findings" to describe a certain series of symptoms that a patient may have. I shall try to do better in the future, providing Dr Halliday also stops writing "I personally."
LOW MOLECULAR WEIGHT DEXTRAN IN THE TREATMENT OF LIVEDO RETICULARIS WITH ULCERATION
Authors: S. W. ISSROFF, D. A. WHITING
Journal: British Journal of Dermatology (1971)

Six cases of livedo reticularis with ulceration were treated with large amounts of low molecular weight dextran. The lesions healed well with this therapy, and subsequent relapses have been less frequent and easier to control. The method of administration is outlined and a possible explanation for the prolonged beneficial effect is advanced.
Do beta-chemokines have clinical relevance in HIV infection?
Authors: C E Mackewicz, E Barker, G Greco, G Reyes-Teran, J A Levy
Journal: Journal of Clinical Investigation (1997)

The role of beta-chemokines in HIV infection was evaluated. The kinetics of regulated upon activation of normal T cell expressed and secreted, macrophage inflammatory protein-1alpha, and macrophage inflammatory protein 1beta production by stimulated T lymphocytes did not differ substantially between HIV-infected (asymptomatic and with AIDS) and uninfected subjects. Maximal production of these beta-chemokines by activated peripheral blood cells was higher in the infected individuals than in uninfected individuals, but no significant difference was observed between healthy infected subjects and AIDS patients. Evaluation of the effect of HIV replication on beta-chemokine production indicated that acute infection of CD4+ T cells with non-syncytia-inducing (NSI) viruses generally increased beta-chemokine production two to eightfold, whereas with SI strains, it led to decreased production. The sensitivity of an individual's virus to beta-chemokine-mediated inhibition correlated with the NSI virus phenotype and a healthy clinical state. 50% of the AIDS patients, however, had NSI viruses that were sensitive to beta-chemokines. Finally, anti-beta-chemokine-neutralizing antibodies caused a more rapid release of HIV by CD4+ T cells naturally infected by NSI, but not SI, viruses indicating that endogenously produced chemokines can affect HIV production in culture. These findings suggest that beta-chemokines may affect HIV replication when an NSI virus is involved, but provide little evidence that they substantially influence HIV infection and pathogenesis.
Psoriasis Day Care Centers
Authors: David L. Cram
Journal: JAMA (1976)

With the rapidly mounting cost of medical care in hospitals, physicians must seek alternative forms of therapy for illnesses that could conceivably be treated by less confining methods. One approach to this problem is the Psoriasis Day Care Center, where psoriasis patients with extensive disease are treated during the day and allowed to return home at night. The advantages include reduced cost, accessibility for more patients, and superior therapeutic results. This day care center concept could be equally applicable to other diseases now routinely treated by complete hospitalization. (<i>JAMA</i>235:177-178, 1976)
Endoscopic Features of Suspected Precancerous Lesions in High-risk Areas for Esophageal Cancer
Authors: M. Crespi, A. Grassi, N. Muñoz, W. Guo-Quing, Y. Guanrei
Journal: Endoscopy (1984)

See also: Double Synchronous Squamous Carcinoma of the EsophagusEndoscopy 1993; 25(08): 544-545DOI: 10.1055/s-2007-1010395
REPORT OF A GROUP OF INFANTS INFECTED BY A TUBERCULOUS ATTENDANT
Authors: ALFRED F. HESS
Journal: JAMA (1913)

Ten children, varying in age from about 2 to 3 years, and occupying one ward in a large infant asylum, were placed in charge of a new attendant May 15 last year. We did not know at the time that this attendant recently had been ill with tuberculosis and that she had been a patient for some months at a sanatorium. Shortly afterward, towaed the end of June, our attention was called to the fact that this nurse was not in good health, that she coughed, and was losing weight. Further inquiry then disclosed that she had suffered from tuberculosis of the lungs. An examination of the sputum was carried out and showed the presence of numerous tubercle bacilli. It was now July 1, 1912. The nurse was immediately removed from the ward, but not until she had been in charge of the children for six weeks. We were naturally
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis
Authors: Keith Syson Chan, Shigetoshi Sano, Kaoru Kiguchi, Joanne Anders, Nobuyasu Komazawa, Junji Takeda, John DiGiovanni
Journal: Journal of Clinical Investigation (2004)

Constitutive activation of signal transducer and activator of transcription 3 (Stat3) has been found in a wide spectrum of human malignancies. Here, we have assessed the effect of Stat3 deficiency on skin tumor development using the 2-stage chemical carcinogenesis model. The epidermis of Stat3-deficient mice showed a significantly reduced proliferative response following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) because of a defect in G1-to-S-phase cell cycle progression. Treatment with the tumor initiator 7,12-dimethylbenz[a]anthracene (DMBA) resulted in a significant increase in the number of keratinocyte stem cells undergoing apoptosis in the bulge region of hair follicles of Stat3-deficient mice compared with nontransgenic littermates. Notably, Stat3-deficient mice were completely resistant to skin tumor development when DMBA was used as the initiator and TPA as the promoter. Abrogation of Stat3 function using a decoy oligonucleotide inhibited the growth of initiated keratinocytes possessing an activated Ha-ras gene, both in vitro and in vivo. In addition, injection of Stat3 decoy into skin tumors inhibited their growth. To our knowledge, these data provide the first evidence that Stat3 is required for de novo epithelial carcinogenesis, through maintaining the survival of DNA-damaged stem cells and through mediating and maintaining the proliferation necessary for clonal expansion of initiated cells during tumor promotion. Collectively, these data suggest that, in addition to its emerging role as a target for cancer therapy, Stat3 may also be a target for cancer prevention strategies.
CHONDRO-DERMATITIS NODULARIS CHRONICA HELICIS
Authors: A. C. ROXBURGH
Journal: British Journal of Dermatology (1927)

Journal Article CHONDRO‐DERMATITIS NODULARIS CHRONICA HELICIS Get access A. C. ROXBURGH, M.D., M.R.C.P. A. C. ROXBURGH, M.D., M.R.C.P. Acting Assistant Physician for Diseases of the Skin, St. Bartholomew's Hospital; Assistant Physician, St. John's Hospital for Diseases of the Skin Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 39, Issue 3, 1 March 1927, Pages 112–114, https://doi.org/10.1111/j.1365-2133.1927.tb10055.x Published: 01 March 1927
INCIDENCE, PREDICTORS AND IMPACT OF STROKE IN ACUTE CORONARY SYNDROME: INSIGHTS FROM THE ACUITY TRIAL
Authors: Philippe Genereux, Samuel Bernard, Tullio Palmerini, Adriano Caixeta, Gregg Rosner, Philip Green, Ke Xu, George Dangas, Roxana Mehran, Gregg Stone
Journal: Journal of the American College of Cardiology (2012)
Predicting cholangiocarcinoma in patients with primary sclerosing cholangitis: An analysis of the serological marker CA 19-9 Nichols JC, Gores GJ, LaRusso NF, Wiesner RH, Nagorney DM, Ritts RE. Diagnostic role of serum CA 19-9 for cholangiocarcinoma in patients with primary sclerosing cholangitis. Mayo Clin Proc 1993; 68: 874–879
Authors: S Rogers
Journal: Hepatology (1994)
Analysis of the RSR' Complex in Lead V <sub>1</sub>
Authors: N. P. DEPASQUALE, G. E. BURCH
Journal: Circulation (1963)

An RSR' complex was present in lead V 1 in the electrocardiograms of 44 of 870 normal people from birth to 30 years of age; an overall incidence of 5 per cent. Analysis of the RSR' from these 44 patients demonstrated the importance of considering age when interpreting the RSR' complex. Criteria for distinguishing normal and abnormal RSR' complexes for various age groups was suggested. These criteria were 85 per cent successful in distinguishing the RSR' complex in patients with congenital heart disease from the RSR' complex in normal subjects.
ON PENICILLIN THERAPY*
Authors: R. M. B. MacKENNA
Journal: British Journal of Dermatology (1947)

Journal Article ON PENICILLIN THERAPY Get access R. M. B. MacKENNA, M.D., F.R.C.P. R. M. B. MacKENNA, M.D., F.R.C.P. Physician in Charge of Skin Department, St. Bartholomew's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 59, Issue 7, 1 July 1947, Pages 239–248, https://doi.org/10.1111/j.1365-2133.1947.tb10894.x Published: 01 July 1947
The Nature of the Immunoreactive Lipotropins in Human Plasma and Tissue Extracts
Authors: Koshi Tanaka, Wendell E. Nicholson, David N. Orth
Journal: Journal of Clinical Investigation (1978)

This study was designed to establish definitively the nature of immunoreactive lipotropin (IR-LPH) in human plasma and tissue extracts. Using gel filtration, gel filtration under denaturing conditions, cationic exchange chromatography, immunoprecipitation, and radioimmunoassay, we have studied normal and tumorous human pituitaries, ectopic ACTH- and LPH-secreting tumors, plasma from normal subjects before and after dexamethasone administration, and plasma from patients with primary adrenal insufficiency and pituitary and nonpituitary ACTH- and LPH-secreting tumors. Except in the plasma and tumors of occasional patients with ectopic ACTH syndrome, the smallest IR-LPH appears to be λ-lipotropin (λLPH), which is often the predominant and occasionally the only IR-LPH present. The other major peptide appears to be βLPH, a 91-amino acid molecule that contains λLPH as its 1-58 sequence. Larger immunoreactive materials were observed in some specimens, but the “big” LPH in one plasma was shown to be λLPH bound to IgG.
311 HLA-B*07-POSITIVE INDIVIDUALS FROM A COMMON SOURCE HCV OUTBREAK ARE PREFERENTIALLY INFECTED BY A VIRAL VARIANT WITH A SUBSTITUTION IN AN HLA-B7-RESTRICTED CD8 EPITOPE
Authors: M. Ruhl, S. Ziegler, J. Nattermann, U. Spengler, J. Timm
Journal: Journal of Hepatology (2011)
Lack of Effectiveness of Cellulose Sulfate Gel for the Prevention of Vaginal HIV Transmission
Authors: Lut Van Damme, Roshini Govinden, Florence M. Mirembe, Fernand Guédou, Suniti Solomon, Marissa L. Becker, B.S. Pradeep, A.K. Krishnan, Michel Alary, Bina Pande, Gita Ramjee, Jennifer Deese, Tania Crucitti, Doug Taylor
Journal: New England Journal of Medicine (2008)

Women make up more than 50% of adults living with human immunodeficiency virus (HIV) infection or the acquired immunodeficiency syndrome (AIDS) in sub-Saharan Africa. Thus, female-initiated HIV prevention methods are urgently needed.We performed a randomized, double-blind, placebo-controlled trial of cellulose sulfate, an HIV-entry inhibitor formulated as a vaginal gel, involving women at high risk for HIV infection at three African and two Indian sites. The primary end point was newly acquired infection with HIV type 1 or 2. The secondary end point was newly acquired gonococcal or chlamydial infection. The primary analysis was based on a log-rank test of no difference in the distribution of time to HIV infection, stratified according to site.A total of 1398 women were enrolled and randomly assigned to receive cellulose sulfate gel (706 participants) or placebo (692 participants) and had follow-up HIV test data. There were 41 newly acquired HIV infections, 25 in the cellulose sulfate group and 16 in the placebo group, with an estimated hazard ratio of infection for the cellulose sulfate group of 1.61 (P=0.13). This result, which is not significant, is in contrast to the interim finding that led to the trial being stopped prematurely (hazard ratio, 2.02 [corrected]; P=0.05 [corrected]) and the suggestive result of a preplanned secondary (adherence-based) analysis (hazard ratio, 2.02; P=0.05). No significant effect of cellulose sulfate as compared with placebo was found on the risk of gonorrheal infection (hazard ratio, 1.10; 95% confidence interval [CI], 0.74 to 1.62) or chlamydial infection (hazard ratio, 0.71; 95% CI, 0.47 to 1.08).Cellulose sulfate did not prevent HIV infection and may have increased the risk of HIV acquisition. (ClinicalTrials.gov number, NCT00153777; and Current Controlled Trials number, ISRCTN95638385.)
Closing the gap: progress for NOTES
Authors: A. Kalloo
Journal: Endoscopy (2009)

Some practitioners believe that the final boundary for the flexible gastrointestinal endoscope exists beyond the gastrointestinal lumen and into the cavities of the peritoneum and thorax, which is the premise for natural orifice transluminal endoscopic surgery (NOTES) [1]. In order for NOTES to gain widespread clinical use, secure closure of the gastrointestinal incision is critical, as mandated by the Natural Orifice Surgery Consortium for Assessment and Research (NOSCAR) [2].