Tamoxifen-Induced Female Androgenetic Alopecia in a Patient with Breast Cancer
Authors: Jean-Pierre M. Ayoub, Vicente Valero, Gabriel N. Hortobagyi
Journal: Annals of Internal Medicine (1997)

Letters1 May 1997Tamoxifen-Induced Female Androgenetic Alopecia in a Patient with Breast CancerJean-Pierre M. Ayoub, MD, Vicente Valero, MD, and Gabriel N. Hortobagyi, MDJean-Pierre M. Ayoub, MDThe University of Texas M.D. Anderson Cancer Center, Houston, TX 77030Search for more papers by this author, Vicente Valero, MDThe University of Texas M.D. Anderson Cancer Center, Houston, TX 77030Search for more papers by this author, and Gabriel N. Hortobagyi, MDThe University of Texas M.D. Anderson Cancer Center, Houston, TX 77030Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-9-199705010-00033 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Tamoxifen is widely used in the management of postmenopausal women with hormonally responsive early and metastatic breast cancer. We describe a case of female androgenetic alopecia in a patient receiving adjuvant tamoxifen therapy for stage II breast cancer.While receiving tamoxifen, the patient reported hot flashes, headaches, and depression. Soon after initiating tamoxifen therapy, she had noticed diffuse thinning of the hair on her head that was worse in the frontal area. Examination revealed diffuse thinning of the hair with moderate receding of the frontal hair line. Distribution of hair on the remainder of the body was ...References1. Callan AW, Montalto J. Female androgenetic alopecia: an update. Australas J Dermatol. 1995; 36:51-5. Google Scholar2. Jaiyesimi IA, Buzdar AU, Decker DA, Hortobagyi GA. Use of tamoxifen for breast cancer: twenty-eight years later. J Clin Oncol. 1995; 13:513-29. Google Scholar3. Signore RJ, von Weiss J. Alopecia of myxedema: clinical response to levothyroxine. J Am Acad Derm. 1991; 25:902-4. Google Scholar4. Hampson JP, Donnelly A, Lewis-Jones MS, Pye JK. Tamoxifen-induced hair colour change [Letter]. Br J Dermatol. 1995; 132:483-4. Google Scholar Author, Article, and Disclosure InformationAffiliations: The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHuman scalp hair: Modulation by various factors and hormones do estrogens inhibit or stimulate—A perplexing perspectivePermanent alopecia in patients with breast cancer after taxane chemotherapy and adjuvant hormonal therapy: Clinicopathologic findings in a cohort of 10 patientsEstrone Sulfate Source of Estrone and Estradiol Formation in Isolated Human Hair Roots: Identification of a Pathway Linked to Hair Growth Phase and Subject to Site-, Gender-, and Age-Related ModulationsAnalysis of quantitative changes in hair growth during treatment with chemotherapy or tamoxifen in patients with breast cancer: a cohort studyPattern Alopecia during Hormonal Anticancer Therapy in Patients with Breast CancerManaging hair loss in midlife womenHair shaft abnormalities after chemotherapy and tamoxifen therapy in patients with breast cancer evaluated by optical coherence tomographyToremifene: An evaluation of its safety profileTamoxifen-Induced Total AlopeciaFabio Puglisi, MD, Giuseppe Aprile, MD, and Alberto Sobrero, MDTestosterone inhibits estrogen‐induced mammary epithelial proliferation and suppresses estrogen receptor expressionTamoxifen 1 May 1997Volume 126, Issue 9Page: 745-746KeywordsAndrogensBreast cancerCellsEstrogensMenopausePatientsSex hormonesThyroidThyroid-stimulating hormoneThyroxine Issue Published: 1 May 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...