Positive Pressure as a Cause of Respirator-Induced Lung Disease.
Authors: John Barsch
Journal: Annals of Internal Medicine (1970)

Meeting Abstracts1 May 1970Positive Pressure as a Cause of Respirator-Induced Lung Disease.John Barsch, M.D., Charles Birbara, M.D., G. W. N. Eggers Jr., M.D., Frank Krumlofsky, M.D., Y. W. Sanit, M.D., Wilfred Smith, M.D., Roy Smith, M.D., James Webster, M.D., F.A.C.P.John Barsch, M.D.Search for more papers by this author, Charles Birbara, M.D.Search for more papers by this author, G. W. N. Eggers Jr., M.D.Search for more papers by this author, Frank Krumlofsky, M.D.Search for more papers by this author, Y. W. Sanit, M.D.Search for more papers by this author, Wilfred Smith, M.D.Search for more papers by this author, Roy Smith, M.D.Search for more papers by this author, James Webster, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-810_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptProlonged artificial ventilation with high oxygen concentration is known on occasion to cause lethal lung damage. The lungs show vascular injury, hyaline membranes, atelectasis, interstitial and intra-alveolar edema, and hemmorhage. This should be designated respirator-induced lung disease, and such changes might be related to lung surfactant depletion. This study was done to evaluate the relative importance of intrapulmonary positive pressure and oxygen concentrations as causes of respirator-induced lung disease and to determine if there was any relation of this disease to lung surfactant activity.Twenty-one mongrel dogs were continuously ventilated under approximated clinical conditions for 22 to 70 hr using... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Ill. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEffects of ventilatory pattern on experimental lung injury caused by high airway pressureEffects of cyclic opening and closing at low- and high-volume ventilation on bronchoalveolar lavage cytokines*The use of a pressure manometer enhances student physiotherapists' performance during manual hyperinflationPercutaneous extracorporeal arteriovenous CO2 removal for severe respiratory failureThe answer is (gently) blowing in the wind?Lung Protection during Mechanical VentilationHas high-frequency ventilation been inappropriately discarded in adult acute respiratory distress syndrome?AN EVIDENCE-BASED APPROACH TO PRESSURE-AND VOLUME-LIMITED VENTILATION STRATEGIESHow to use articles about harmThe aetiology, consequences and prevention of barotrauma: a critical review of the literatureIntravenacaval Membrane Oxygenation and Carbon Dioxide Removal in Severe Acute Respiratory FailureBarotrauma: Detection, Recognition, and ManagementBarotrauma and alveolar recruitmentExtracorporeal Carbon Dioxide Removal in ARDSVentilation in Severe ARDS: Inverted Ratio Ventilation and CO2 RemovalAre Low Tidal Volumes Safe?The (ir)Relevance of Short Term StudiesMechanical Pulmonary Ventilation at High Airway Pressures: Is it Safe?The Pulmonary Edema of Heroin Toxicity—An Example of the Stiff Lung SyndromeTemporary Support of the Lungs - the Artificial Lung 1 May 1970Volume 72, Issue 5Page: 810-810KeywordsAttentionEdemaLungsOxygenPulmonary diseases Issue Published: 1 May 1970 PDF DownloadLoading ...