tbuckley/cabot-search huggingface dataset:
A Cohort Study of Traffic-Related Air Pollution Impacts on Birth Outcomes
Authors: Michael Brauer, Cornel Lencar, Lillian Tamburic, Mieke Koehoorn, Paul Demers, Catherine Karr
Journal: Environmental Health Perspectives (2008)

Evidence suggests that air pollution exposure adversely affects pregnancy outcomes. Few studies have examined individual-level intraurban exposure contrasts.We evaluated the impacts of air pollution on small for gestational age (SGA) birth weight, low full-term birth weight (LBW), and preterm birth using spatiotemporal exposure metrics.With linked administrative data, we identified 70,249 singleton births (1999-2002) with complete covariate data (sex, ethnicity, parity, birth month and year, income, education) and maternal residential history in Vancouver, British Columbia, Canada. We estimated residential exposures by month of pregnancy using nearest and inverse-distance weighting (IDW) of study area monitors [carbon monoxide, nitrogen dioxide, nitric oxide, ozone, sulfur dioxide, and particulate matter < 2.5 (PM2.5) or < 10 (PM10) microm in aerodynamic diameter], temporally adjusted land use regression (LUR) models (NO, NO2, PM2.5, black carbon), and proximity to major roads. Using logistic regression, we estimated the risk of mean (entire pregnancy, first and last month of pregnancy, first and last 3 months) air pollution concentrations on SGA (< 10th percentile), term LBW (< 2,500 g), and preterm birth.Residence within 50 m of highways was associated with a 22% (95% CI, 0.81-1.87) [corrected] increase in LBW. Exposure to all air pollutants except O3 was associated with SGA, with similar odds ratios (ORs) for LUR and monitoring estimates (e.g., LUR: OR = 1.02; 95% CI, 1.00-1.04; IDW: OR = 1.05; 95% CI, 1.03-1.08 per 10-microg/m3 increase in NO). For preterm births, associations were observed with PM2.5 for births < 37 weeks gestation (and for other pollutants at < 30 weeks). No consistent patterns suggested exposure windows of greater relevance.Associations between traffic-related air pollution and birth outcomes were observed in a population-based cohort with relatively low ambient air pollution exposure.
Procedure for dealing with clinical complaints in hospitals
Authors: R. Gruneberg
Journal: BMJ (1981)

Therapeutics Bulletins.7This recommendation was purely on the grounds that dextromoramide tablets are more convenient than morphine solution.However, morphine is now available in a 10 mg slow-release tablet formulation and therefore this point is no longer valid.Clinical experience in terminal care, both in Leeds and elsewhere,8-'0 has led us to conclude that dextromoramide is a less suitable analgesic than morphine, diamorphine, or phenazocine for the control of pain in terminal illness.
Posterior subtalar joint synoviography and corticosteroid injection in rheumatoid arthritis.
Authors: F Beaudet, A S Dixon
Journal: Annals of the Rheumatic Diseases (1981)

Ten posterior subtalar joints of 8 patients with rheumatoid arthritis and 12 posterior subtalar joints of 6 cadavers were studied by contrast synoviography. In the rheumatoid group the abnormalities included posterior capsule distension, filling defects caused by hypertrophic synovitis, limited or irregular filling of the anterior recess of the joint in 5 out of 10, and communication with the ankle joint in 3 out of 10. None of the cadaveric joints showed posterior capsule distension or limited or irregular filling of the anterior recess of the joint, but communication with the ankle was present in 2 joints. The joints of the patients were injected with a 1:1 mixture of sodium iothalamate 70% (Conray 420) and triamcinolone hexacetonide (Lederspan) 20 mg/ml. All patients noticed a decrease in and an improvement in walking beginning 24-48 hours after the examination. Quantitative thermography was done immediately before and 1 after injection in 2 patients who showed an improvement in thermographic index. We conclude that hindfoot inflammatory pain arising from the posterior subtalar joint is caused by distension with hypertrophic synovitis which can be difficult to detect clinically.
SPINA BIFIDA OR HYDRORRHACHITIS.
Authors: PAUL F. EVE
Journal: JAMA (1901)

Spina bifida or hydrorrhachitis is a congenital mal- formation consisting of a cleft in the vertebral column with protrusion of the lining membranes of the spinal cord.This deformity is caused by an arrest of ossification of the vertebral arches, and is situated in any region of
Serum free medium increases expression of markers of differentiation in human colonic crypt cells.
Authors: P Gibson, O Rosella, G Young
Journal: Gut (1994)

In colitis, colonic epithelial cells have a shortened life span but show normal or increased expression of phenotypic markers of differentiation. This study examined the effect of differing culture conditions on the expression of such markers in colonic crypt cells. Crypt cells were enzymatically isolated from macroscopically normal large bowel mucosa resected because of neoplasia, inflammatory bowel disease or non-neoplastic non-inflammatory conditions. Cells cultured in the presence of serum exhibited a doubling of the rate of protein synthesis (measured by 14C-leucine uptake; p &lt; 0.001) compared with autologous cells cultured in the absence of serum without evidence of loss of cell viability (assessed by 51Cr release from prelabelled cells) or of change in the rate of cell proliferation (assessed by total DNA content and 3H-thymidine uptake). Irrespective of the underlying colonic disease, crypt cells cultured in the absence of serum exhibited increased expression of phenotypic markers of differentiation compared with those cultured with serum: the rate of glycoprotein synthesis relative to that of protein synthesis increased by a mean of 59% and the cellular expression of brush border glycoproteins, alkaline phosphatase, and carcinoembryonic antigen significantly increased. The effects seen could not be mimicked by addition of dexamethasone or insulin to serum free medium. Thus, under less optimal (serum free) culture conditions, colonic crypt cells express phenotypic markers of differentiation at an accelerated rate suggesting that unfavourable microenvironmental conditions themselves are probably in part responsible for the normal or increased expression of such markers in colitis.
New self-assembled nanogels based on host–guest interactions: Characterization and drug loading
Authors: Ruxandra Gref, Catherine Amiel, Karine Molinard, Samia Daoud-Mahammed, Bernard Sébille, Brigitte Gillet, Jean-Claude Beloeil, Catherine Ringard, Véronique Rosilio, Jaques Poupaert, Patrick Couvreur
Journal: Journal of Controlled Release (2006)
683. Bronchoscope-Guided, Targeted Lobar Aersolization of HDAd into the Lungs of Nonhuman Primate Results in Exceedingly High Pulmonary Transduction Uniformally throughout the Entire Lung with Negligible Toxicity
Authors: Peter Hiatt, Nicola Brunetti-Pierri, Ruth McConnell, Donna Palmer, Julie Katkin, David Dimmock, Yu Zuo, Milton Finegold, Arthur Beaudet, Philip Ng
Journal: Molecular Therapy (2006)

Uniform delivery of gene therapy vectors to all lung lobes will be important for successful CF gene therapy. However, this important objective has not been achieved in large animals. To address this important obstacle, we developed an approach to specifically delivery vector into each lung lobe. In this strategy, an intracorporeal nebulizing catheter (the AeroProbe) is inserted into a bronchoscope to permit visual targeted aerosolization of vector sequentially and specifically into each lung lobe.
MDR1 Gene Expression in NOD/SCID Repopulating Cells after Retroviral Gene Transfer under Clinically Relevant Conditions
Authors: A.J. Schilz, B. Schiedlmeier, K. Kühlcke, S. Fruehauf, C. Lindemann, W.J. Zeller, M. Grez, A.A. Fauser, C. Baum, H.-G. Eckert
Journal: Molecular Therapy (2000)

We have adapted a recently published protocol for retroviral gene transfer into hematopoietic cells [A. J. Schilz et al. (1998) Blood 92: 3163–3171] with respect to clinical requirements such as large-volume vector stock generation, adequate cell source, high cell numbers, and serum-free conditions. We present data on transduction efficacy and expression of the multidrug resistance 1 (MDR1) gene in human CD34+ cells from mobilized peripheral blood (PB) mediated by a gibbon ape leukemia virus (GALV)-pseudotyped retroviral vector. Using a 1-day cytokine-mediated prestimulation, consisting of human interleukin (IL)-3, IL-6, stem cell factor (SCF), Flt-3 ligand (FL), and thrombopoietin (TPO), followed by a 3-day transduction procedure, we were able to detect up to 51% CD34+ cells expressing MDR1. Xenotransplantation of transduced cells into NOD/LtSz-scid/scid (NOD/SCID) mice resulted in a mean engraftment level of 23% (0.1 to 87%). As shown by quantitative PCR analysis, a mean of 12.7% (range 0.3 to 55%) of the engrafted human cells in the bone marrow of chimeric mice contained the MDR1 cDNA. Furthermore, enhanced expression of MDR1 above control levels was detected in up to 15% of the engrafted human cell population. Our data suggest that NOD/SCID repopulating cells derived from mobilized PB can be transduced efficiently with existing retroviral vector systems under clinically applicable conditions. We have adapted a recently published protocol for retroviral gene transfer into hematopoietic cells [A. J. Schilz et al. (1998) Blood 92: 3163–3171] with respect to clinical requirements such as large-volume vector stock generation, adequate cell source, high cell numbers, and serum-free conditions. We present data on transduction efficacy and expression of the multidrug resistance 1 (MDR1) gene in human CD34+ cells from mobilized peripheral blood (PB) mediated by a gibbon ape leukemia virus (GALV)-pseudotyped retroviral vector. Using a 1-day cytokine-mediated prestimulation, consisting of human interleukin (IL)-3, IL-6, stem cell factor (SCF), Flt-3 ligand (FL), and thrombopoietin (TPO), followed by a 3-day transduction procedure, we were able to detect up to 51% CD34+ cells expressing MDR1. Xenotransplantation of transduced cells into NOD/LtSz-scid/scid (NOD/SCID) mice resulted in a mean engraftment level of 23% (0.1 to 87%). As shown by quantitative PCR analysis, a mean of 12.7% (range 0.3 to 55%) of the engrafted human cells in the bone marrow of chimeric mice contained the MDR1 cDNA. Furthermore, enhanced expression of MDR1 above control levels was detected in up to 15% of the engrafted human cell population. Our data suggest that NOD/SCID repopulating cells derived from mobilized PB can be transduced efficiently with existing retroviral vector systems under clinically applicable conditions.
Developmental regulation of human cortex transcription and its clinical relevance at single base resolution
Authors: Andrew E Jaffe, Jooheon Shin, Leonardo Collado-Torres, Jeffrey T Leek, Ran Tao, Chao Li, Yuan Gao, Yankai Jia, Brady J Maher, Thomas M Hyde, Joel E Kleinman, Daniel R Weinberger
Journal: Nature Neuroscience (2014)
The Heart Muscle and the Electrocardiogram in Coronary Disease
Authors: JOHN J. SAŸEN, WARNER F. SHELDON, CHARLES C. WOLFERTH
Journal: Circulation (1955)

Methods, designed to study in detail the lesions resulting from coronary disease and to reconstruct accurately the form of all ventricular muscle lesions, have been applied to 100 consecutive electrocardiographed patients who were found to have at least one severe coronary narrowing. Reclassification of lesions into four categories was found necessary to deal with the patterns of damage disclosed. This approach permits conclusions regarding evolution of muscle damage, relationships of arterial obstruction to muscle damage distribution, and the significance of ischemia which would have been impossible otherwise. The value of the new classification for electrocardiography will be discussed in a subsequent section of the report.
Genome-wide association analyses in east Asians identify new susceptibility loci for colorectal cancer
Authors: Wei-Hua Jia, Ben Zhang, Keitaro Matsuo, Aesun Shin, Yong-Bing Xiang, Sun Ha Jee, Dong-Hyun Kim, Zefang Ren, Qiuyin Cai, Jirong Long, Jiajun Shi, Wanqing Wen, Gong Yang, Ryan J Delahanty, Bu-Tian Ji, Zhi-Zhong Pan, Fumihiko Matsuda, Yu-Tang Gao, Jae Hwan Oh, Yoon-Ok Ahn, Eun Jung Park, Hong-Lan Li, Ji Won Park, Jaeseong Jo, Jin-Young Jeong, Satoyo Hosono, Graham Casey, Ulrike Peters, Xiao-Ou Shu, Yi-Xin Zeng, Wei Zheng
Journal: Nature Genetics (2012)
Synergistic Effects of Family History of Hepatocellular Carcinoma and Hepatitis B Virus Infection on Risk for Incident Hepatocellular Carcinoma
Authors: Rohit Loomba, Jessica Liu, Hwai–I. Yang, Mei–Hsuan Lee, Sheng–Nan Lu, Li–Yu Wang, Uchenna H. Iloeje, San–Lin You, David Brenner, Chien–Jen Chen
Journal: Clinical Gastroenterology and Hepatology (2013)
Interferon gamma release assay for differentiating tuberculosis among pneumonia cases in acute healthcare setting
Authors: G. Lui, N. Lee, S.W. Cheung, J.S.Y. Lam, B.C.K. Wong, K.W. Choi, K.T. Wong, R.Y.K. Wong, C.S. Cockram, D.S.C. Hui, R.C.Y. Chan
Journal: Journal of Infection (2011)
Cardiac rehabilitation programmes: are women less likely to attend?
Authors: H. M. McGee, J. H. Horgan
Journal: BMJ (1992)

Pedestrian injuries are a leading cause of childhood mortality.'The analysis of trends in pedestrian death rates may provide information on the determinants of the incidence of these injuries.2We have examined the relation between child pedestrian mortality and traffic volume in New Zealand from 1967 to 1987. Methods and resultsChild (aged <15 years) pedestrian death rates (ICD code E814-7) were calculated by using National Health Statistics Centre mortality data for 1967 to 1987.A traffic volume index, based on data from traffic coun- ters on urban highways throughout New Zealand, and the number of registered vehicles were obtained from the Ministry of Transport.There was an annual average of 32 5 pedestrian deaths over the study period (3-7/100000 children yearly).From 1967 to 1975 there was a 57-1% increase in traffic volume and a 69-7% increase in the death rate.Between 1975 and 1981 traffic volume increased by only 5-2% and death rates fell by 46-4%.After 1982 traffic volume rose by 27-6% and death rates by 53-7% (see figure).The number or registered vehicles increased steadily by 91-3% between 1967 and 1987.1.6 5
Delusions of cutaneous wire wool
Authors: J.L. Burton
Journal: British Journal of Dermatology (1986)

Journal Article Delusions of cutaneous wire wool Get access J.L. Burton J.L. Burton Dermatology Department, Bristol Royal Infirmary, Bristol BS2 8HW, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 114, Issue 5, 1 May 1986, Page 642, https://doi.org/10.1111/j.1365-2133.1986.tb04081.x Published: 01 May 1986
Song Among the Ruins
Authors: Thomas Hamilton
Journal: JAMA (1991)

As international tensions mount in the Middle East, it is perhaps timely that we are presented with a book that reminds us of the unthinkable consequences of nuclear conflict. Spanning more than 40 years, William Schull's<i>Song Among the Ruins</i>stems from his work in Japan with the Atomic Bomb Casualty Commission—currently the Radiation Effects Research Foundation. Though they are not the primary subject of this book, the author summarizes the genetic findings of the work conducted by him and his Japanese and American colleagues. Under radiation exposure conditions similar to those in Hiroshima and Nagasaki, the results suggest that for a dose of 100 rad (1 Gy), the risk of untoward pregnancy (in children conceived after parental exposure) is increased less than 10% over natural baseline risk. While commenting on the difficulties in extrapolating to lower doses, he states that exposure to 5 rad (0.05 Gy, the current annual
Pediatric Dermatology for the Primary Care Practitioner
Authors: Samuel M. Bluefarb
Journal: JAMA (1979)

The book is not intended to be a definitive work in pediatric dermatology but merely a guide for the primary care physician in making a diagnosis, administering proper therapy, and deciding on appropriate consultation. To this end the authors have accomplished their purpose. The authors' aim in writing this book, was fivefold—(1) to let the primary care provider know about the condition or disease being described to recognize it, (2) to discuss management, (3) to advise when consultation or referral to a specialist should be made, (4) to describe what the primary care provider can expect the consultant to do, and (5) to define the role the primary care provider should play after referral. Drs Solomon and Esterly have written a brief introduction of the anatomy of the skin and a survey of the common conditions that the family practitioner will see. The common dermatoses are then discussed in detail
Small-scale Trial with Sabin Attenuated Type 1 Poliovirus Vaccine in a Semi-closed Community
Authors: J. M. Hoskins, D. Hobson, V. Udall, T. Madland, A. P. Goffe, C. H. Stuart-Harris, E. G. Herzog
Journal: BMJ (1962)

The desirable properties of a live poliovirus vaccine are that it should be of attenuated neurovirulence, be genetically stable during growth in the human intestine, and so be safe for the vaccinated individual and the community.It should moreover be able to infect the alimentary tract readily, and elicit an antibody response after such infection (W.H.O., 1960).Although the vaccine viruses developed by Sabin appear to possess most of these qualities, it is known that intestinal passage may give rise to some variation.Nevertheless, no serious consequences have been reported amongst the 100 millions or so that have now received Sabin attenuated vaccine in many parts of the world.A small- scale study with the Sabin type 3 virus has already been reported from Shefflield (Clarke et al., 1958), and the present trial was performed with type 1 vaccine to obtain information about: (1) the spread, within a poliovirus- free semi-closed community, after infection of a number of children with a single dose of living type 1 polio- virus vaccine; (2) the degree and duration of virus excretion; (3) the serological response to vaccination; and (4) the genetic stability of the vaccine virus strain on passage through the human gut.The virus used was the living, attenuated, L Sc, 2ab type 1 vaccine developed by Sabin, and received from him in 1959 in the form of infected monkey-kidney-tissue culture fluid.Since 1959 it had been stored at -70°C. Trial ProcedureThe patients were all under 4 years of age and in a single ward of a long-stay orthopaedic hospital.They were under treatment for various orthopaedic conditions, such as Perthes's disease and congenital dislocation of the hip.None had previously had clinical poliomyelitis.Before the trial began its nature was fully explained to their parents, and their permission obtained.For six months before vaccination stools collected twice- weekly from every child were examined for.poliovirus and other viruses.During this control period no polio- virus of any serotype was recovered from any individual in the ward, but E.C.H.O.virus type 1 (two children) and one adenovirus were isolated.The two children excreting E.C.H.O.
PCB congener profile in the serum of humans consuming Great Lakes fish.
Authors: H E Humphrey, J C Gardiner, J R Pandya, A M Sweeney, D M Gasior, R J McCaffrey, S L Schantz
Journal: Environmental Health Perspectives (2000)

The State of Michigan has a long history of research into human exposure to environmental contaminants through consumption of recreationally caught fish. A large cohort of Lake Michigan residents who eat fish (fish-eaters) and those who do not eat fish (nonfish-eaters) established in 1980 served as the basis for the congener-specific polychlorinated biphenyl (PCB) exposure evaluation reported here. In this paper we present the serum PCB congener profile for a subset of this cohort who were over 50 years of age. Serum samples were collected in 1993-1995 and were evaluated by a dual column capillary column gas chromatography procedure capable of detecting over 90 PCB congeners. This evaluation demonstrated significant PCB exposure in the fish-eaters (mean serum PCB of 14.26 ppb; n = 101). This elevated exposure allowed the establishment of a detailed profile of the PCB congeners found in humans exposed by this route. Twenty-two congeners of varying concentrations were the most prevalent and constituted over 95% of the total PCB present in most subjects. Four congeners, 138/163 (2,2',3,4,4',5-PCB/2,3,3',4', 5,6-PCB), 180 (2,2',3,4,4',5,5'-PCB), and 153 (2,2',4,4',5,5'-PCB), accounted for 55-64% of the total PCB load. Other congeners, some of toxicologic significance, were also detected by this analytical protocol. Nonfish-eaters had lower total serum PCB levels (mean = 4. 56; n = 78), but the same general pattern of PCB congeners was present. It was demonstrated that careful selection of a subset of prevalent PCB congeners could provide a cost-effective assessment of exposure without losing critical scientific information.
APPENDICITIS IN TRAINED NURSES.
Authors: J. N. HALL
Journal: JAMA (1905)

The great frequency of this disease among the pupils of the training school of the Denver City and County Hospital has attracted my attention, as well as that of other members of the staff, for some years. I have therefore collected the notes of 10 cases occurring in the past four years, and all operated on successfully by Drs. Freeman, Fleming, Craig, Van Meter, Bagot and Lyman. Nine of these cases were under my care, as far as diagnosis and the medical treatment were concerned, the remaining one under that of Dr. Henry Sewall. Several trained nurses came from outside the hospital for operation for appendicitis during this interval, but, not belonging to the school, they do not concern us at present. At least three mild cases, presumably positive as to diagnosis, but either refusing or delaying operation, are also omitted from consideration in order that we may deal only
Cytomegalovirus vaccine work progressing
Authors: P. Gunby
Journal: JAMA (1982)

Recent reports, extending earlier findings of a possible cytomegalovirus (CMV)-Kaposi's sarcoma (KS) relationship, also are serving to refocus attention on continuing CMV vaccine studies. One report comes from a ten-month study of ten homosexual men in San Francisco, aged 22 to 48 years, who had the disseminated form of KS, preceded by CMV infections Cytomegalovirus was recovered from urine, saliva, semen, gastric secretions, or peripheral blood leukocytes of seven of these patients. Anti-CMV IgG antibodies (titers ranging from 128 to more than 4,096) were detected in nine patients (one died before serum was obtained), and anti-CMV IgM antibodies (titers ranging from about 8 to more than 128) in seven (<i>Lancet</i>1982;2:125-127). A decade earlier, herpeslike viral particles were reported in five of eight tissue culture lines from African KS (also the disseminated form) biopsy specimens (<i>J Nat Cancer Inst</i>1972;49:1509-1513). Later in that decade, serum antibody to CMV was detected