tbuckley/cabot-search huggingface dataset:
Natural vs Synthetic Vitamin E
Authors: George Alperin
Journal: JAMA (1973)

To the Editor.—  Dr. Ayers questioned (225:1124, 1973) Nagy's reply to the question of natural vs synthetic vitamins as being biologically equivalent. He referred to the difference in optical rotation of vitamin E derived from natural vs synthetic sources and their difference in potency on a milligram-for-milligram basis.  Many substances that are identical chemically except for optical activity (dextro [d] vs levo [1] form) are not biologically equivalent. Further, there are a variety of officially recognized forms of vitamin E listed in theNational Formulary: α-D or α-dextrolevo (DL) tocopherol, α-D or α-DL tocopheryl acetate, α-D or α-DL tocopheryl acid succinate, mixed tocopheryls concentrate, and α-D tocopheryl acetate concentrate. The concentrates are obtained from edible vegetable oils or from the by-products of their refining. TheNational Formulary(NF XIII) establishes appropriate standards of purity for each and requires vitamin E products to be labeled in terms of international units as
Markers of collagen and basement membrane metabolism in sera of patients with progressive systemic sclerosis.
Authors: N G Guseva, N V Anikina, R Myllyla, L Risteli, J Risteli, J V Chochlova, K I Kivirikko, V A Nassonova
Journal: Annals of the Rheumatic Diseases (1991)

The concentrations of the amino terminal propeptide of type III procollagen, the 7S domain of type IV collagen, and the fragment P1 of laminin (PIIINP, 7S, and P1 respectively) and the activity of galactosylhydroxylysyl glucosyltransferase (GGT) in serum were evaluated as indicators of disease activity in a cross sectional study of 84 patients with progressive systemic sclerosis. The mean values of PIIINP, P1, and GGT were raised in progressive systemic sclerosis, 19-32% of patients having abnormal values of the various tests. PIIINP, measured with two different assays, and P1 were associated with active, acute, or subacute disease. GGT also correlated positively with some acute phase proteins in the whole group, without a clear association with the course of the disease. Arthritis was associated with increased PIIINP concentrations as well as with an increased activity of GGT. Kidney disease led to raised concentrations of the degradation products of PIIINP. Raynaud9s phenomenon in the hands was related to increased PIIINP concentrations.
Pulmonary arterial V waves in mitral regurgitation: clinical and experimental observations.
Authors: R Grose, J Strain, M V Cohen
Journal: Circulation (1984)

Pulmonary arterial early diastolic waves (V waves) were investigated in patients and experimental animals with mitral regurgitation. V waves exceeding systolic pressure in the pulmonary artery were recorded in the main pulmonary artery with micromanometer catheters both in patients and animals, eliminating the possibility of catheter artifact. In experimental animals, aortic closure preceded pulmonic closure by 33 +/- 12 msec at baseline. With the creation of acute mitral insufficiency, a pulmonary arterial V wave occurred in six of eight animals. Early pulmonic valve closure occurred only in the six animals with a pulmonary arterial V wave. In these animals, pulmonic closure preceded aortic closure by 28 +/- 7 msec during mitral insufficiency (p less than .05). Of 70 patients with severe mitral regurgitation at cardiac catheterization, 14 had a pulmonary arterial V wave. In five patients recordings with micromanometer catheters were made and early pulmonic closure was also observed in four of these patients who had pulmonary arterial V waves at rest or upon provocation. Patients with pulmonary arterial V waves had a more acute onset of symptoms, shorter duration of mitral regurgitation, higher pulmonary capillary wedge V waves, and lower pulmonary arterial resistances than patients without them and were more likely to have nonrheumatic mitral regurgitation.
Book: The NHS Direct Healthcare Guide
Authors: C. Cates
Journal: BMJ (2000)

Ian Banks NHS Direct, £1.99, pp 128 ISBN 1 85775 476 X Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> The vast majority of people's symptoms are dealt with at home, perhaps after consultation with family or friends, and they never get as far as a healthcare professional. This presents a particular challenge for Dr Banks and his editorial board in writing a guide “to help you decide when it is safe to treat yourself or the person you are worried about.” Can such a guide lead to an increase in those with serious … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Lipid peroxidation in neonatal rat heart cell cultures: effects of cumene hydroperoxide
Authors: A. VAN DER LAARSE, R. H M JULICHER, L. STERRENBERG, C. H F B. VAN TRESLONG
Journal: Cardiovascular Research (1986)

Journal Article Lipid peroxidation in neonatal rat heart cell cultures: effects of cumene hydroperoxide Get access ARNOUD VAN DER LAARSE, ARNOUD VAN DER LAARSE **From the Laboratory of Cardiobiochemistry University Hospital Leiden, Leiden, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar RINETTE H M JULICHER, RINETTE H M JULICHER ‡ †From the Department of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, State University of Utrecht, Utrecht, The Netherlands ‡Address for correspondence and reprints: Rinette H M Julicher, Department of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, State University of Utrecht, Utrecht, The Netherlands. Search for other works by this author on: Oxford Academic PubMed Google Scholar LYDI STERRENBERG, LYDI STERRENBERG †From the Department of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, State University of Utrecht, Utrecht, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar CORNELIA H F BLOYS VAN TRESLONG CORNELIA H F BLOYS VAN TRESLONG **From the Laboratory of Cardiobiochemistry University Hospital Leiden, Leiden, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 20, Issue 1, January 1986, Pages 20–25, https://doi.org/10.1093/cvr/20.1.20 Published: 01 January 1986
Tracking the Cocaine Epidemic
Authors: Herbert D. Kleber
Journal: JAMA (1991)

POLICYMAKING in the fight against drug abuse should be driven by accurate epidemiologic data. By providing information on patterns and consequences of use and demographics of users, such data can show trends over time and the effectiveness of existing strategies. None of the existing datasets are flawless, as might be expected for information on illegal activities in a variety of populations. Thus, absolute numbers are less important than what the indexes show when looked at as a whole over prolonged periods.
Diagnostic and prognostic role of PET/CT in patients with chronic lymphocytic leukemia and progressive disease
Authors: F R Mauro, S Chauvie, F Paoloni, A Biggi, G Cimino, A Rago, M Gentile, F Morabito, M Coscia, M Bellò, G M Sacchetti, D Rossi, L Laurenti, F Autore, M Campanelli, F Trastulli, E Nicolai, M Riminucci, G Gaidano, A Guarini, A Gallamini, R Foà
Journal: Leukemia (2015)
The Endoscopic Variety of Duodenal Villous Adenoma - an Experience with Ten Cases
Authors: S.K. Batra, B.M. Schuman, R.R. Reddy
Journal: Endoscopy (1983)

Ten cases of villous adenoma of the duodenum among 8,754 endoscopic examinations of the upper gastrointestinal tract were found over a nine year period. The varied clinical manifestations included gastrointestinal bleeding in five cases, partial duodenal obstruction in four, and jaundice with common bile duct obstruction in two. In only two cases did radiological examination indicate the diagnosis of villous adenoma of the duodenum in all ten cases preoperatively but was negative for carcinoma in one. Due to improved diagnostic techniques villous adenoma of the duodenum is being diagnosed at an early stage, and with appropriate surgical treatment the survival rate for this group of patients should improve.
Scene in Print: The Cryptic Orient
Authors: TOSHIHIKO AOKI
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 October 1972Scene in Print: The Cryptic OrientTOSHIHIKO AOKI, YASUHIRO ONOTOSHIHIKO AOKISearch for more papers by this author, YASUHIRO ONOSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-4-663_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCase 1. A female, aged 22, who had drunken away with her fiance in the early morning of Christmas day, was run over by a taxi while crouching on the street. The fiance told the taxi-driver to bring her to hospital, but asked him to wait a moment while he would go to do his needs. But in his absence, the driver ran away with the victim. Not finding the car on his return to the spot of the accident, the man searched around there in vain, and he went to a police stand to inform the accident.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByStereoselective syntheses of chiral (3S,9bS)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones 1 October 1972Volume 77, Issue 4Page: 663-663 Issue Published: 1 October 1972 PDF DownloadLoading ...
Respiratory Syncytial Virus — From Chimps with Colds to Conundrums and Cures
Authors: Caroline Breese Hall, John T. McBride
Journal: New England Journal of Medicine (1991)

Three and a half decades ago Morris et al.1 recovered from a chimpanzee with a cold a virus that had infected the entire colony and its handler. In subsequent years this contagious chimpanzee coryza agent earned a new name, respiratory syncytial virus. It is now recognized as the most important cause of lower respiratory tract disease in young children. Each year 95,000 children in the United States are hospitalized with lower respiratory tract disease due to respiratory syncytial virus, and more than 4500 die. Logarithmically greater numbers of children with respiratory syncytial virus infection are treated as outpatients. Recognition of . . .
Circulating Tumor DNA — Ready for Prime Time?
Authors: Marc Lippman, C. Kent Osborne
Journal: New England Journal of Medicine (2013)

Multiple aspects of the management of metastatic breast cancer need improvement. Patients are anxious about their risk of recurrence and are disappointed at the lack of reliable tests for the early detection of recurrence, even though there are no data to suggest that detection of asymptomatic recurrences a few weeks or months earlier is of any benefit. It seems reasonable that identifying resistance to a new therapy and progression of disease at the earliest moment would avoid needless toxic effects of therapies doomed to fail and would permit earlier initiation of other potential therapies. Finally, the means of estimating overall . . .
Pacing on Demand in Atrioventricular Conduction Disturbances of the Heart.
Authors: Robert H. Goetz
Journal: Annals of Internal Medicine (1968)

s1 May 1968Pacing on Demand in Atrioventricular Conduction Disturbances of the Heart.Robert H. Goetz, M.D.Robert H. Goetz, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1155_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptContinuous cardiac pacing with totally implanted pulse generators has now become standard therapy for patients with complete heart block and Adams-Stokes syndrome. The pacemaker assumes complete control over ventricular conduction suppressing all spontaneous activity. However, in patients who go in and out of heart block, pacing by means of a continuous fixed rate pacemaker results in a competition between naturally induced stimuli and the pacemaker-produced beats for capture of the ventricular contraction. This results in a bizarre cardiac rhythm, tachycardias, and possibly ventricular fibrillation if a pacemaker beat should fall into the vulnerable period of the naturally induced beat. Recent... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bronx, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1155-1156KeywordsCardiac pacingFallsHeartHeart ratePacemakersTachycardiaVentricular fibrillation Issue Published: 1 May 1968 PDF DownloadLoading ...
Angiographic prevalence of high-risk coronary artery disease in patient subsets (CASS).
Authors: B R Chaitman, M G Bourassa, K Davis, W J Rogers, D H Tyras, R Berger, J W Kennedy, L Fisher, M P Judkins, M B Mock, T Killip
Journal: Circulation (1981)

The prevalence of coronary artery stenoses greater than or equal to 70% or left main stenosis greater than or equal to 50% was evaluated in 20,391 patients who underwent angiography in the Coronary Artery Surgery Study from 1975-1979. After the patients with unstable angina or myocardial infarction were excluded, the disease prevalence in the 8157 patients with definite angina, probable angina, and nonspecific chest pain was 93%, 66% and 14% in men and 72%, 36% and 6% in women (p less than 0.001). The age and sex of the patients and character of chest pain were important determinants of disease prevalence and severity. Left main or three-vessel coronary disease occurred in more than 50% of middle-aged men and older women with definite angina and in more than 50% of men who had probable angina and were older than 60 years of age. In contrast, left main coronary disease occurred in less than 2% of 1282 men and less than 1% of 1397 women with nonspecific chest pain regardless of age. In this latter patient subset, less than 5% of men and less than 1% of women in each decade under 60 years had left main or three-vessel coronary artery disease. Thus, high-risk coronary disease is common in middle-aged patients with definite angina and older patients with probable angina, but is rare in patients with nonspecific chest pain. Indications and guidelines for diagnostic noninvasive tests and coronary angiography could be based on these results.
Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging
Authors: Eun-Kyung Lim, Hyun-Ouk Kim, Eunji Jang, Joseph Park, Kwangyeol Lee, Jin-Suck Suh, Yong-Min Huh, Seungjoo Haam
Journal: Biomaterials (2011)
The influence of beta-blockers on QT interval in patients with long QT syndrome
Authors: Wojciech Zareba, Arthur J. Moss, Jesaia Benhorin, Emanuela H. Locati, Peter J. Schwartz, G.Michael Vincent, Silvia G. Priori, Michael Lehmann, Jennifer L. Robinson, Li Zhang
Journal: Journal of the American College of Cardiology (1996)
Biliary cholesterol hypersecretion in gallstone-susceptible mice is associated with hepatic up-regulation of the high-density lipoprotein receptor SRBI
Authors: Michael Fuchs, Boris Ivandic, Oliver Müller, Carmen Schalla, Jürgen Scheibner, Petra Bartsch, Eduard F. Stange
Journal: Hepatology (2001)

Enhanced hepatocellular trafficking of cholesterol to the bile canaliculus and cholesterol hypersecretion appears critical for gallstone formation. Therefore, we studied in more detail the hepatic cholesterol transport pathways in a mouse model of cholesterol gallstone disease. Biliary lipid secretion rates, plasma lipoprotein levels, hepatic expression of lipoprotein receptors, lipid regulatory enzymes, and putative cholesterol transporting proteins were analyzed in gallstone–susceptible C57L/J and gallstone–resistant AKR/J mice, which were fed a lithogenic diet. Biliary cholesterol hypersecretion in C57L mice was associated with decreased plasma high–density lipoprotein (HDL) cholesterol levels and significant hepatic induction of the HDL receptor (SRBI) and cholesteryl ester hydrolase. In response to the lithogenic diet, fatty–acid binding protein of liver (FABPL) was markedly induced in both mouse strains. Caveolin 1 was elevated only in plasma membranes of gallstone–susceptible C57L mice, which also failed to down–regulate cholesterol synthesis. These data suggest a role of the reverse cholesterol transport pathway for genetically determined gallstone susceptibility in the mouse.
Exposure to crystalline silica and risk of lung cancer: the epidemiological evidence.
Authors: H. Weill, J. C. McDonald
Journal: Thorax (1996)

This review updates the published epi- demiological literature since 1986, a year chosen because the International Agency for Research on Cancer (IARC) conducted a thor- ough review of papers published before that date.The IARC working group concluded at that time that the evidence for carcinogenicity of crystalline silica in experimental animals was sufficient, while in man it was limited.'These conclusions led the IARC to classify crystalline silica as 2A -that is, "probably carcinogenic to humans".2The evidence on which these judgements are based was summarised in an editorial published in 1989.3Only brief ref- erence will be made to papers published before that date.For the present review, relevant fac- tors taken into account include: (1) the dis- tinction between silica exposure and silicosis;(2) study design and quality; (3) confounding exposures, including smoking; and (4) de- monstration of dose dependency.Very few studies are available of cohorts, defined by their employment, that have been exposed to crystalline silica but not to other potentially carcinogenic materials.As with most other epidemiological studies which focus on lung cancer as the primary outcome of interest, smoking could rarely be accounted for fully in the reviewed literature.Also, past silica exposure levels could only be approximated or ranked in an ordinal fashion, if exposure was estimated at all.
Abstract 3703: Nanoparticle-induced targeted pro-apoptotic peptide in glioblastoma
Authors: Lilach Agemy, Dinorah Friedmann Morvinski, Venkata Ramana Kotamraju, Kazuki N. Sugahara, Inder M. Verma, Erkki Ruoslahti,
Journal: Cancer Research (2010)

Abstract Glioblastomas multiforme (GBM) are the most common and lethal form of intracranial tumors. They account for approximately 70% of the 22,500 new cases of malignant primary brain tumors that are diagnosed in adults in the United States each year. Although relatively uncommon, malignant gliomas are associated with disproportionately high morbidity and mortality (median survival is only 12 to 15 months). Malignant gliomas are among the most vascular of human tumors. Tumor vasculature has proven to be particularly well suited as a site for receptor-based targeting. It expresses a multitude of molecules that are not expressed in the vessels of normal tissues. Our laboratory screens phage-displayed peptide libraries in vivo and ex vivo to discover specific targets in tumor vessels. One of the peptides, CGKRK (1) binds to the blood vessels in various kinds of tumors. Initial experiments showed that intravenously injected CGKRK peptide effectively homes to lentiviral (H-RasV12-sip53)-induced glioma in mice. We coupled the CGKRK peptide to the alpha-helical amphipathic peptide D[KLAKLAK]2, which is toxic to eukaryotic cells if it internalized into the cells (2). The chimeric peptide, when added to actively growing HUVEC or U87 glioma cells colocalized with mitochondria, whereas D[KLAKLAK]2 did not. Iron oxide nanoworms (NW) coated with the chimeric D[KLAKLAK]2-CGKRK peptide were 100-200-fold more toxic to the HUVEC and U87 cells than the free peptide in vitro and specifically accumulated in the blood vessels of glioma. Treatment of lentiviral induced glioma in mice with the D[KLAKLAK]2-CGKRK-PEG-NW inhibited tumor growth and showed a significant survival increase compared to control-treated mice. 1. Hoffman, J.A., et al. Progressive vascular changes in a transgenic mouse model of squamous cell carcinoma. Cancer Cell 4, 383-391 (2003). 2. Ellerby, H.M., et al. Anti-cancer activity of targeted pro-apoptotic peptides. Nat Med 5, 1032-1038 (1999). *These authors contributed equally to this work Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3703.
Mediastinal staging of non-small-cell lung cancer with positron emission tomography.
Authors: R Chin, R Ward, J W Keyes, R H Choplin, J C Reed, S Wallenhaupt, A S Hudspeth, E F Haponik
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

To determine the usefulness of positron emission tomography with fluoro-2-deoxyglucose (PET-FDG) in assessing mediastinal disease in patients with non-small-cell lung cancer (NSCLC) and to compare its yield to that of computed tomography (CT), we performed a prospective consecutive sample investigation in a university hospital and its related clinics. In 30 patients with NSCLC with clinical stage I (T1-2, NO, MO) disease, we compared the results of chest CT and PET-FDG with the findings at surgical exploration of the mediastinum. Seven (77%) of nine patients with surgically proven mediastinal metastasis were identified by the PET-FDG results, with four false-positives in 21 patients with negative lymph node dissections (p = 0.004). Using the results of pathologic examination of mediastinal lymph nodes as the criterion standard, the diagnostic sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) for PET-FDG imaging of mediastinal metastases were 78%, 81%, 80%, 64%, and 89%, respectively. The sensitivity, specificity, accuracy, PPV, and NPV for chest CT in the detection of mediastinal metastasis were 56%, 86%, 77%, 63%, and 87%, respectively. CT and PET-FDG results agreed in 21 patients. The diagnostic accuracy of the combined imaging modalities was 90%. We concluded that mediastinal uptake of FDG correlates with the extent of mediastinal involvement of NSCLC and may contribute to preoperative staging. PET-FDG imaging complements chest CT in the noninvasive evaluation of NSCLC, and strategies for its use merit further investigation.
Presence or absence of a known diabetic ketoacidosis precipitant defines distinct syndromes of “A-β+” ketosis-prone diabetes based on long-term β-cell function, human leukocyte antigen class II alleles, and sex predilection
Authors: Ramaswami Nalini, Kerem Ozer, Mario Maldonado, Sanjeet G. Patel, Christiane S. Hampe, Anu Guthikonda, Jesus Villanueva, E. O'Brian Smith, Lakshmi K. Gaur, Ashok Balasubramanyam
Journal: Metabolism (2010)
Plasminogen activator inhibitor-1 deficiency retards diabetic nephropathy
Authors: Susanne B. Nicholas, Elsa Aguiniga, Yuelan Ren, Jason Kim, Joyce Wong, Nalini Govindarajan, Masakuni Noda, Wei Wang, Yasuko Kawano, Alan Collins, Willa A. Hsueh
Journal: Kidney International (2005)