"Studies on the Nature of Gouty Tophi" by Max Freudweiler, 1899
Authors: JOSEPH M. BRILL
Journal: Annals of Internal Medicine (1964)

Medical History1 March 1964"Studies on the Nature of Gouty Tophi" by Max Freudweiler, 1899(An Inflammatory Response to Injected Sodium Urate, 1899)JOSEPH M. BRILL, M.D., DANIEL J. MCCARTY JR., M.D.JOSEPH M. BRILL, M.D., DANIEL J. MCCARTY JR., M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-3-486 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONRecently a rapid, simple technique using polarized light microscopy for urate crystal identification in synovial fluid was developed by McCarty and Hollander.* Acute gouty attacks were marked by phagocytosis of the crystals by mononuclear and polymorphonuclear leukocytes.† The sensitivity and specificity of the procedure is such that it has been described as a pathognomonic test for gout;‡ 90 of the last 91 gouty joint fluids examined in our laboratory have contained urate crystals.Interest in the sterile host response peculiar to acute gouty arthritis was reawakened recently with the demonstration of a phlogistic response to synthetic microcrystalline sodium urate...References (M. Freudweiler)1. GARROD Natur und Behandlung der Gicht. Uebersetzt von Eisenmann, Wuerzburg 1861. Google Scholar2. EBSTEIN Natur und Behandlung der Gicht. Wiesbaden 1882. Google Scholar3. V. NOORDEN Lehrbuch der Pathologie des Stoffwechsels. Berlin 1892. Google Scholar4. KLEMPERER Zur Pathologie u. Therapie der Gicht. Deutsche med. Wochenschr, 1895, p. 655. CrossrefGoogle Scholar5. GALVANI citiert nach Ebstein l.s.c. Google Scholar6. LICHATSCHEFF Experimentelle Untersuchungen ueber die Folgen der Uretheren-unterbindung bei Huehnern mit besonderer Beruecksichtigung der nachfolgenden Uratablagerungen. Ziegler's Beitraege zur pathol. Anatomie. Bd. XX p. 102. Google Scholar7. PFEIFFER Kongress fuer innere Medicin 1889. Google Scholar8. RIEHL Zur Anatomie der Gicht. Wiener Klin. Wochenschr. 1897, p. 761. Google Scholar9. ROBERTS (no reference given). Google Scholar10. NEUMEISTER Lehrbuch der physiologischen Chemie. p. 592-593, Jena 1897. Google Scholar11. MORITZ Congr. f. inn. Med. Google Scholar12. LEWIN Ueber lokale Gewerbe-Argyrie. Berl. Klin. Wochenschr. 1886, p. 417. Google Scholar13. METSCHNIKOFF Immunitaet. Handbuch f. Hygiene von Weyl. Gustav Fischer, Jena 1897, p. 18. Google Scholar14. MARCHAUD Ueber die Bildung von Riesenzellen um Fremdkoerper etc. Virch. Arch. Bd. 93, p. 518, 1883 und Untersuchungen ueber die Einheilung von Fremdkoerper. Ziegler's Beitraege Bd. IV. 1889. CrossrefGoogle Scholar15. LITTEN Klinische Mittheilungen. Verhandlungen der Aerzlichen Gesellschaft in Berlin. Berliner Klin. Wochenschr. 1885, p. 812. Google Scholar16. LANGHANS-NAEGELI Ueber den Einfluss von Pilzen auf die Bildung von Riesenzellen mit wandstaendigen Kernen. Arch. f. experiment. Pathol. u. Pharmakologie. Bd. XIX, 1885. Google Scholar17. MANASSE cit. nach Krueckmann. Google Scholar18. RUGE cit. nach Krueckmann. Google Scholar19. ARNOLD cit. nach Krueckmann. Google Scholar20. KRUECKMANN Ueber Fremdkoerpertuberkulose und Fremdkoerperriesenzellen, Virchow's Arch. 138 Bd. Suppl. 1895. Google Scholar21. FREUDBERG Ueber den Einfluss von Saeuren und Alkalien auf die Alkalescenz des menschlichen Blutes und die Reaction des Harnes. Virch. Archiv. Bd. 125, p. 566. CrossrefGoogle Scholar22. MORDHORST Zeitschrift fuer klin. Medicin. Bd. XXXII. Suppl. p. 92-93. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaFrom the Section of Rheumatology, Department of Medicine, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania.This work was supported in part by training grant 2A-5201 (C3) (a) and research grant 06615-01 National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, United States Public Health Service, Bethesda, Maryland.Dr. Freudweiler's work was translated by Dr. Brill from Deutsches Archiv für Klinische Medizin. 63: 266, 1899.Requests for reprints should be addressed to Daniel J. McCarty, Jr., M.D., Hahnemann Medical College, 230 North Broad Street Philadelphia, Pennsylvania.*MCCARTY, D. J., JR., HOLLANDER, J. L.: The identification of urate crystals in gouty synovial fluid. Ann. Intern Med. 54: 452, 1961.†MCCARTY, D. J., JR.: Phagocytosis of urate crystals in gouty synovial fluid. Amer. J. Med. Sci. 243: 288, 1962.‡MCCARTY, D. J., JR.: The diagnosis of gouty arthritis: 18 months experience with a pathognomonic test. Postgrad. Med. 33: 142, 1963.§SEEGMILLER, J. E., HOWELL, R. R., MALAWISTA, S.: The inflammatory reaction to sodium urate. JAMA 180: 469, 1962.∥FAIRES, J. S., MCCARTY, D. J., JR.: Acute arthritis in man and dog after intrasynovial injection of sodium urate crystals. Lancet II: 7258, 682, 1962.#RIEHL, G.: Zur anatomie der gicht. Wïen. Klin. Wschr. 1897. Translated by BRILL, J. M., 1963. 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CHRISTIAN, M.D.An experimental model of acute inflammation in manUrates and Kinin Formation in Synovial FluidSuppression of metabolic accompaniments of phagocytosis by colchicinePathology of goutThe inflammatory reaction to microcrystalline sodium urateExperimental investigations into the origin of gouty tophiThe pendulum of progress in gout: From crystals to hyperuricemia and back 1 March 1964Volume 60, Issue 3Page: 486-505KeywordsArthritisHospital medicinePhagocytosisPrevention, policy, and public healthResearch grantsResearch laboratoriesRheumatologySpecificitySynovial fluidUric acid Issue Published: 1 March 1964 PDF DownloadLoading ...