Dose Response to Vitamin D Supplementation in Postmenopausal Women
Authors: J. Christopher Gallagher, Adarsh Sai
Journal: Annals of Internal Medicine (2012)

Letters4 September 2012Dose Response to Vitamin D Supplementation in Postmenopausal WomenJ. Christopher Gallagher, MD and Adarsh Sai, MBBSJ. Christopher Gallagher, MDFrom Creighton University School of Medicine, Omaha, NE 68131, and Loma Linda University Medical Center, Loma Linda, CA 92354. and Adarsh Sai, MBBSFrom Creighton University School of Medicine, Omaha, NE 68131, and Loma Linda University Medical Center, Loma Linda, CA 92354.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-5-201209040-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We disagree with Dr. Chausmer's suggestion that measuring serum 25-(OH)D levels has no value. Serum 25-(OH)D is a valid indicator of total body vitamin D level because there is no other biomarker, and it is the substrate for 1,25-(OH)2D, the main regulatory hormone in calcium and vitamin D metabolism. Whether 25-(OH)D has an independent physiologic action on the vitamin D receptor is unknown because 1,25-(OH)2D is always present. Because 25-(OH)D circulates in blood at a concentration 1000 times higher than 1,25-(OH)2D, it could play a role in nonphysiologic situations (for example, renal failure).Serum 1,25-(OH)2D levels usually do ...References1. Need AG, O'Loughlin PD, Morris HA, Coates PS, Horowitz M, Nordin BE. Vitamin D metabolites and calcium absorption in severe vitamin D deficiency. J Bone Miner Res. 2008;23:1859-63. [PMID: 18597633] CrossrefMedlineGoogle Scholar2. Sai AJ, Walters RW, Fang X, Gallagher JC. Relationship between vitamin D, parathyroid hormone, and bone health. J Clin Endocrinol Metab. 2011;96:436-46. [PMID: 21159838] CrossrefMedlineGoogle Scholar3. Institute of Medicine. 2011 Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academies Pr; 2011. Google Scholar4. Priemel M, von Domarus C, Klatte TO, Kessler S, Schlie J, Meier S, et al. Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J Bone Miner Res. 2010;25:305-12. [PMID: 19594303] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: J. Christopher Gallagher, MD; Adarsh Sai, MBBSAffiliations: From Creighton University School of Medicine, Omaha, NE 68131, and Loma Linda University Medical Center, Loma Linda, CA 92354.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M11-1566. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDose Response to Vitamin D Supplementation in Postmenopausal Women J. Christopher Gallagher , Adarsh Sai , Thomas Templin II , and Lynette Smith Dose Response to Vitamin D Supplementation in Postmenopausal Women Arthur B. Chausmer Metrics Cited byEffect of Low-Dose Vitamin D Supplementation on Serum 25(OH)D in School Children and White-Collar WorkersAssessment of Vitamin D status In Patients of Chronic Low Back Pain of Unknown EtiologySerum 25(OH)D response to vitamin D3 supplementation: A meta-regression analysisImpact of calcium and vitamin D insufficiencies on serum parathyroid hormone and bone mineral density: Analysis of the fourth and fifth Korea National Health and Nutrition Examination Survey (KNHANES IV-3, 2009 and KNHANES V-1, 2010) 4 September 2012Volume 157, Issue 5Page: 384-385KeywordsBody mass indexCalciumFatsHyperparathyroidismNutritionOverweightPhosphatesRecommended dietary allowanceRenal failureVitamin D ePublished: 4 September 2012 Issue Published: 4 September 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...