tbuckley/cabot-search huggingface dataset:
Personal and Public Safety Issues Related to Arrhythmias That May Affect Consciousness: Implications for Regulation and Physician Recommendations
Authors: Andrew E. Epstein, William M. Miles, David G. Benditt, A. John Camm, Elizabeth J. Darling, Peter L. Friedman, Arthur Garson, John Collins Harvey, Gregory A. Kidwell, George J. Klein, Paul A. Levine, Francis E. Marchlinski, Eric N. Prystowsky, Bruce L. Wilkoff
Journal: Circulation (1996)
Book Review Managing Relationships with Industry: A Physician's Compliance Manual By Steven C. Schachter, William Mandell, Scott Harshbarger, and Randall Grometstein. 288 pp. Burlington, MA, Elsevier Academic Press, 2008. $39.95. 978-0-12-373653-6
Authors: David J. Rothman
Journal: New England Journal of Medicine (2009)
Vaccination Against Poliomyelitis with Live Virus Vaccines: 1. A Trial of TN Type II Vaccine. 2. A Trial of SM Type I Attenuated Poliomyelitis Virus Vaccine. 3. The Evaluation of TN And SM Virus Vaccines
Authors: D. S. Dane, G. W. A. Dick, J. H. Connolly, O. D. Fisher, F. McKeown, M. Briggs, R. Nelson, D. Wilson
Journal: BMJ (1957)
PROGNOSIS FOR PSYCHIATRIC ILLNESS IN THE AGED
Authors: M. STRAKER
Journal: American Journal of Psychiatry (1963)

The review and analysis of 100 patients aged 60 and older, examined and treated in private psychiatric practice, has served to clarify a number of important questions regarding geriatric patients. An impoverished social life and retirement from the job often set the stage for the development of illness. Forty-six percent presented a special emotional vulnerability. The reaction to separation threats or realities, retirement, personal illness and family conflicts emerged as critical environmental stresses. Fifty percent presented physical diseases, primarily cardiovascular or degenerative in nature. Cerebral organic contaminants were present in 39%. Although these factors tended to reduce the recovery rate, they did not prevent recovery in many patients. The predominant psychiatric diagnosis was the depressive group of reactions. In the consideration of this particular group, the possibilities for improvement are excellent, especially when the pretreatment illness period is not protracted. Many complicating factors which now retard treatment or which in the first instance lead to breakdown are potentially preventable. This will occur through progress and advances in medical knowledge, through greater understanding of the problems of the aged person, and ultimately through the introduction of restorative interventions at the community level. Treatment measures, although empiric in nature, resulted in an overall 55% recovery or improved rate. The older patient can be treated with all the psychiatric techniques now available. When treatment is pursued energetically and with optimism, reversal of serious psychiatric illness in the aged person results, and chronic illness and deterioration is prevented, or postponed. The willingness of the therapist to become involved in the problem, to remain interested, and to search for answers to unknown processes, is critical to the success or failure of treatment in meeting psychiatric illnesses of the aged. Community resources must be developed in imaginative ways. Active treatment centers for chronic illness are an essential need, to provide hospital care and day center care. The development of psychiatric units in general hospitals must be supported. The six weeks in, six weeks out program for geriatric patients described by Delargy(13) is an intriguing therapeutic concept. Development of home care programs, the greater use of visiting homemakers and the development of post-retirement employment facilities can benefically influence the medical, social and psychiatric aspects of the aging process.
Proposal for Changes in Cystoscopic Follow&amp;ndash;Up of Patients with Low&amp;ndash;Grade pTa Bladder Tumor
Authors: &Ouml;mer &Ouml;ge, Erim Erdem, Necmettin Ats&uuml;, Ahmet &trade; ahin, Haluk &Ouml;zen
Journal: European Urology (2000)
Abstract 480: Establishment of human metastatic hepatocellular carcinoma HCCLM3 nude rat model for drug evaluation
Authors: Jing Zhang, Haiyan Wu, Ruihong Zhang, Yanmei Zhang, Mei-shu Shi, Jeff Duan, Kevin Zhang
Journal: Cancer Research (2010)

Abstract Currently most of antitumor pharmacology studies are performed in mice using either human xenograft or murine tumors. However, the utility of rat tumor models has not been fully explored. Some of the obvious advantages of using rats remain to be validated, for example, the easy combination of pharmacokinetic study with an efficacy study, the easy performance of animal procedures, the more options for local dosing or interventions, etc. HCCLM3 is one of the human hepatocellular carcinoma(HCC) lines that are originally derived from Chinese HCC primary tumor and well established in mouse model system over last 20 years. To realize the potential utilities of rats for tumor models, especially for the need of evaluating various local treatments for the HCC, we examined the growth and metastasis of HCCLM3 tumor following subcutaneous and orthotopic xenograft in immunodeficient rats (RNU nude rats, Charles River). Following either subcutaneous or orthotopic inoculation, HCCLM3 was able to successfully grow up with 100% take-up rate. The subcutaneous tumor grew more quickly in nude rats than in BALB/c nude mice and the tumor weight reached about 10% of body weight 28 days after inoculation. The treatment with Sutent (28mg/kg, p.o. 5 times per week) significantly inhibited the subcutaneous tumor growth by 93% (P&amp;lt;0.05). In comparison, the orthotopic tumor grew rather slower but showed much stronger lung metastasis potential which was not observed in nude mice in 28 days. HCCLM3 in nude rats also demonstrated the growth pattern of the single nodule growth, different from the intrahepatic dissemination and multiple nodule development in the nude mice. Our established HCCLM3 subcutaneous and orthotopic xenograft rat models provided additional useful tools for evaluation of therapeutic profile of drug candidates and different interventional strategies for the treatment of human hepatocellular carcinoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 480.
Discordant Hepatobiliary Scintigraphy and Computed Tomography in Hepatic Metastasis
Authors: Albert J. Moreno, Peter Fredericks, Paul R. Cordts, Ricardo R.T. Velez, Gottlieb L. Turnbull
Journal: Clinical Nuclear Medicine (1987)

A 58-year-old man demonstrated multiple photopenic defects throughout the liver on hepatobiliary imaging using Tc-99m DISIDA. Computed tomography of the abdomen, however, did not show the defects seen on scintigraphy. At surgery, the liver was found to be extensively involved with metastatic adenocarcinoma.
Red faces in Tavistock Square
Authors: W E Snell
Journal: BMJ (1977)

occasion, 20 or so ticks off my skin, not giving them time to dig in.They are easy to remove if it is done promptly after a walk through their habitat.Ticks can transmit a variety of arbovirus and rickettsial infections to man, but probably rarely do so in Britain.Some 33 cases a year of Q fever are reported in Scotland.Possibly some of these may have been transmitted by tick bites but probably most infections are acquired through milk, meat, or the handling of infected animals or their afterbirths.
Insulin and gall stones
Authors: K W HEATON
Journal: Gut (2001)

Editor,—In showing for the first time that raised serum insulin is a risk factor for incident gall stones, independent of body mass index, Misciagna et al (

(2000) Gut 47:144–7; 



) have made an important contribution. However, they do not seem to realise that we had similar findings in the East Bristol Gallstone Study (population based like theirs)—namely, that raised plasma insulin is a risk factor for prevalent gall stones, at least in men.1 In our study, another significant factor was abdominal fatness or central obesity, but not body mass index …
Restrictions on doctor in South Africa
Authors: G. Keynes, J. E. Piercy, R. Greene, A. S. Mason, H. E. A. Farran, M. J. Lange, A. W. G. Goolden
Journal: BMJ (1967)

As regards the suggestion that there should be 100 full-time "A" doctors, my feeling is that there has been misunderstanding here.At the outset it was indicated that if fulltime doctors were to run the new service this could be done by between 80 and 100 doctors, but I am not of the view that it was ever intended that the new service should be run by full-time doctors, but by part-time, as at present, and that the number required would be about 400 instead of the present 1,600 to 2,000.It is a known fact that at present 80% of all appointed factory doctors' work is carried out by 20% of the appointed factory doctors-namely, about 400.Far from accepting our demise with equanimity, we view the new service as a challenge, and a worth-while job for us to carry out with skill and experience.-Iam, etc.,
Thyroidectomy for Amiodarone-Induced Thyrotoxicosis
Authors: Alan P. Farwell
Journal: JAMA (1990)

Amiodarone hydrochloride, an iodine-rich drug used in the treatment of tachyarrhythmias, is responsible for the development of thyrotoxicosis in approximately 10% of patients who reside in areas of moderate iodine deficiency. Treatment of amiodarone-induced thyrotoxicosis is difficult since the drug has a prolonged half-life, cardiac decompensation due to underlying heart disease occurs often, and discontinuation of amiodarone therapy may not be possible. We report a patient with severe thyrotoxicosis who received amiodarone for 34 months. Prolonged treatment with methimazole, potassium perchlorate, iopanoic acid, and dexamethasone was unsuccessful in controlling the hyperthyroid state. A near-total thyroidectomy resulted in rapid amelioration of thyrotoxicosis. Since surgery results in rapid control of thyrotoxicosis and permits continued therapy with amiodarone, we suggest that near-total thyroidectomy warrants consideration as definitive treatment for resistant amiodarone-induced thyrotoxicosis.
Access to Information about AIDS
Authors: Robert J. Veenstra, Jeannine Cyr Gluck
Journal: Annals of Internal Medicine (1991)

Medical information related to human immunodeficiency virus (HIV) infection is highly diverse, and the practicing physician or researcher may find specific information difficult to locate. To provide timely access to medical information on topics related to the acquired immunodeficiency syndrome (AIDS), several computer-based products have recently been developed. Some are available from vendors of online information systems, whereas others are available only on CD-ROM or floppy disk. We review several computer-based products. AIDSLINE is the most comprehensive bibliographic index, AIDSTRIALS contains specific information about ongoing unpublished investigational studies, and AIDS Knowledge Base from San Francisco General Hospital is an up-to-date electronic textbook covering all aspects of AIDS. COMPACT LIBRARY: AIDS operates on a microcomputer and combines several databases, including full-text AIDS-related articles from nine major medical journals. AIDS References from the Bureau of Hygiene and Tropical Diseases provides critical analysis of publications worldwide. Although smaller in size than AIDSLINE, about one third of the publications covered by this resource are not covered by AIDSLINE.
Elevated serum uric acid levels impair coronary microvascular function in patients with idiopathic dilated cardiomyopathy
Authors: Hakan Gullu, Dogan Erdogan, Mustafa Caliskan, Derya Tok, Sevsen Kulaksizoglu, Aylin Yildirir, Haldun Muderrisoglu
Journal: European Journal of Heart Failure (2006)
CAR-dependent and CAR-independent pathways of adenovirus vector–mediated gene transfer and expression in human fibroblasts
Authors: Chisa Hidaka, Eric Milano, Philip L. Leopold, Jeffrey M. Bergelson, Neil R. Hackett, Robert W. Finberg, Thomas J. Wickham, Imre Kovesdi, Peter Roelvink, Ronald G. Crystal
Journal: Journal of Clinical Investigation (1999)

Primary fibroblasts are not efficiently transduced by subgroup C adenovirus (Ad) vectors because they express low levels of the high-affinity Coxsackie virus and adenovirus receptor (CAR). In the present study, we have used primary human dermal fibroblasts as a model to explore strategies by which Ad vectors can be designed to enter cells deficient in CAR. Using an Ad vector expressing the human CAR cDNA (AdCAR) at high multiplicity of infection, primary fibroblasts were converted from being CAR deficient to CAR sufficient. Efficiency of subsequent gene transfer by standard Ad5-based vectors and Ad5-based vectors with alterations in penton and fiber was evaluated. Marked enhancement of binding and transgene expression by standard Ad5 vectors was achieved in CAR-sufficient fibroblasts. Expression by AdΔRGDβgal, an Ad5-based vector lacking the arginine-glycine-aspartate (RGD) αV integrin recognition site from its penton base, was achieved in CAR-sufficient, but not CAR-deficient, cells. Fiber-altered Ad5-based vectors, including (a) AdF(pK7)βgal (bearing seven lysines on the end of fiber) (b) AdF(RGD)βgal (bearing a high-affinity RGD sequence on the end of fiber), and (c) AdF9sK βgal (bearing a short fiber and Ad9 knob), demonstrated enhanced gene transfer in CAR-deficient fibroblasts, with no further enhancement in CAR-sufficient fibroblasts. Together, these observations demonstrate that CAR deficiency on Ad targets can be circumvented either by supplying CAR or by modifying the Ad fiber to bind to other cell-surface receptors.
Cancer of the gastrointestinal tract. II. Esophagus: Treatment--localized and advanced. Pretreatment laparotomy
Authors: P. Rubin
Journal: JAMA (1974)

The primary cancer is the major obstacle to cure in cancer of the esophagus. In most series, the reported survival figures with present methods are 1% to 5% if all patients are included. The effect of regional lymph node involvement on survival could be appraised more realistically if local ablation was achieved. The basic rule in treatment of alimentary tract cancers is resection of the primary cancer with wide margins, and en bloc nodal resections. Although this approach is feasible with abdominal viscera in the stomach and colon, the lymphatic drainage of the esophagus is too dispersed to permit it. The lymph node echelons at risk in esophageal cancer include the cervical, supraclavicular, posterior mediastinal, retrotracheal, cardiac, and those of the lesser curvature regions. The abundant submucosal communications allow for rapid spread via peristaltic activity in the longitudinal axis of the esophagus; this communication system renders all nodal stations at
The emerging field of mobile health
Authors: Steven R. Steinhubl, Evan D. Muse, Eric J. Topol
Journal: Science Translational Medicine (2015)

The surge in computing power and mobile connectivity have fashioned a foundation for mobile health (mHealth) technologies that can transform the mode and quality of clinical research and health care on a global scale. Unimpeded by geographical boundaries, smartphone-linked wearable sensors, point-of-need diagnostic devices, and medical-grade imaging, all built around real-time data streams and supported by automated clinical decision–support tools, will enable care and enhance our understanding of physiological variability. However, the path to mHealth incorporation into clinical care is fraught with challenges. We currently lack high-quality evidence that supports the adoption of many new technologies and have financial, regulatory, and security hurdles to overcome. Fortunately, sweeping efforts are under way to establish the true capabilities and value of the evolving mHealth field.
Fourteen cases of euthanasia to be referred to French police
Authors: Brad Spurgeon
Journal: BMJ (2004)

Fourteen of eighteen suspected cases of euthanasia at the University Hospital in Besancon, in eastern France, are euthanasia in the eyes of the law, according to a medical expert's report delivered to the city's prosecutor in January and made public last week.

After a local health authority in April 2002 found evidence of possible euthanasia in the deaths of the patients in the intensive care unit between 1998 and 2001 the case was handed over to the Besancon prosecutor for a preliminary analysis by a medical expert.

“Of the 18 cases examined by the expert—all of which were hopeless cases, where it was decided to abandon treatment—fourteen were, in the eyes of the law, euthanasia,” Jean-Yves Coquillat, the …
Scientists welcome ruling on patent on breast cancer gene
Authors: Rory Watson
Journal: BMJ (2007)

The European Patent Office has rejected an appeal by the US drug company Myriad Genetics and the University of Utah against an earlier decision revoking the patent concerning the BRCA1 gene and its applications.

The ruling has been welcomed by European researchers working on tests for a predisposition to breast and ovarian cancer. Dominique Stoppa-Lyonnet, head of the genetics department at the Institut Curie in Paris, said: “This is an important decision, since it means we can continue our work without fear of being attacked for infringing a patent.”

The decision is the latest stage in …
Manual of Basic Neuropathology
Authors: Orville T. Bailey
Journal: JAMA (1973)

This manual is a teaching aid of unusual importance. By means of an easily understood text and well-selected illustrations, it introduces the student to neuropathology and enables him to progress to the larger texts with a minimum of confusion. A special feature is the use of clear and accurate diagrams that give better insight into sequences in neuropathology than many pages of text. As examples, cerebral vascular disease, cerebellar degenerations, Wallerian degeneration, and nerve sheath tumors are remarkably clarified by the diagrams. Rubinstein's translation contributes to the value of the book for American usage, considerably beyond rendering the text into elegant English. He has brought it into conformity with the attitudes of English and American neuropathologists by occasional changes in the text and addition of footnotes. A few revisions represent advances in the two years since the original publication. These discrete alterations obviate the disadvantages of most European texts for
Dual cardiac microdialysis to assess drug-induced changes in interstitial purine metabolites: adenosine deaminase inhibition versus adenosine kinase inhibition
Authors: S Manthei
Journal: Cardiovascular Research (1998)

Objective: The purpose of this study was: 1) to evaluate a dual microdialysis technique coupled with local drug administration in the regionally ischemic rabbit heart, and; 2) to assess the ischemia-induced changes in interstitial fluid (ISF) adenosine during inhibition of adenosine deaminase or adenosine kinase. Methods: Two microdialysis probes were implanted parallel to each other and separated by 5 mm in myocardium perfused by a branch of the left coronary artery. Probes were used to sample myocardial ISF and to deliver drugs locally to the myocardium; purine metabolite concentrations in the collected dialysate were used as indices of ISF levels. Three groups of pentobarbital-anesthetized rabbits were studied. In a control group (n = 6), both probes were perfused with Krebs-Henseleit buffer. In the second and third groups, one probe was perfused with buffer, whereas the other probe was perfused with buffer containing 1 mM erythro-2-(2-hydroxy-3-nonyl)adenine (EHNA) (n = 5), an adenosine deaminase inhibitor, or 10 μM iodotubercidin (n = 9), an adenosine kinase inhibitor. All animals were exposed to 30 min of regional myocardial ischemia followed by 60 min of reperfusion. Results: In the control group, similar increases in dialysate purine metabolites during ischemia were observed in both probes. Locally administered EHNA increased dialysate adenosine prior to ischemia and decreased dialysate inosine and hypoxanthine. During ischemia, the increase in dialysate adenosine in the EHNA-perfused probe was markedly augmented, while the increases in inosine and hypoxanthine were attenuated. In contrast, local infusion of iodotubercidin did not alter dialysate purine metabolites before ischemia, but there was a modest augmentation of adenosine during ischemia. These data illustrate the feasibility of dual microdialysis for assessing the effect of locally administered compounds on interstitial metabolite concentration in the regionally ischemic rabbit heart. Furthermore, adenosine deaminase inhibition has a more profound adenosine augmenting effect than adenosine kinase inhibition in the rabbit heart.
Reduction in the response to coronary and iliac artery injury with photodynamic therapy using 5-aminolaevulinic acid
Authors: M Jenkins
Journal: Cardiovascular Research (2000)

Photodynamic therapy (PDT) uses red light (non-thermal, non-ionising) to activate a previously administered photosensitizing drug. This inhibits neointimal hyperplasia in injured arteries in small animals where it appears safe and well tolerated. Our aim was to develop a method for percutaneous application of PDT to iliac and coronary arteries in a large animal model and investigate its influence on the remodeling and intimal hyperplastic response to balloon injury.Studies were undertaken on 13 juvenile Large White-Landrace crossbred pigs (15-20 kg). After intravenous administration of the photosensitizing agent 5-amino laevulinic acid (ALA), the arterial tree was accessed via the left common carotid artery and balloon injuries made by over-distension in both common iliacs (thirteen animals) and one or two main coronary arteries (eight animals). Half the injured sites were then illuminated with red laser light transmitted via the catheter. Animals were culled 28 days later and tissue harvested for histomorphometry.Compared with control injured vessels, PDT treated, balloon injured coronary arteries had a larger lumen (1.4 vs. 0.8 mm2, P = 0.002), larger area within the external elastic lamina (2.8 vs. 2.2 mm2, P = 0.006) and smaller area of neointimal hyperplasia (0.4 vs. 0.7 mm2, P = 0.06), 28 days after intervention. Less neointimal hyperplasia and the absence of negative remodeling resulted in the lumen of PDT-treated, injured segments being the same as that of adjacent reference segments (1.5 vs. 1.6 mm2). Similar trends, but with smaller differences, were seen in the iliac vessels.Intra-arterial, trans-catheter PDT favourably influences the arterial response to balloon injury in both the coronary and peripheral circulations. This technique offers a promising new approach to restenosis after endovascular procedures.
TCT-445 Patients with 3-vessel Coronary Artery Disease and Impaired LVEF undergoing PCI with Impella 2.5 Hemodynamic Support Have Improved 90-Day Outcomes Compared to Intra-Aortic Balloon Pump: A Substudy of The PROTECT II Trial
Authors: Jason Kovacic, Annapoorna Kini, Subhash Banerjee, George Dangas, Roxana Mehran, Jeffrey Popma, William W. O'Neill, Samin Sharma
Journal: Journal of the American College of Cardiology (2013)