pH DEFENDED—IS IT DEFENSIBLE?
Authors: A. GORMAN HILLS
Journal: Annals of Internal Medicine (1966)

Letters and Comments1 November 1966pH DEFENDED—IS IT DEFENSIBLE?A. GORMAN HILLS, M.D., EDWARD L. REID, M.D.A. GORMAN HILLS, M.D.Search for more papers by this author, EDWARD L. REID, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-5-1150 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: The article by Drs. Lennon and Lemann (1) published in the August issue of the ANNALS OF INTERNAL MEDICINE makes a further contribution to quantification of the compensatory adjustments that will normally resist deviations of plasma pH in acid-base disturbances of both respiratory and metabolic origin. It is nevertheless to be hoped that the authors will gain no adherents for their proposal to replace the Henderson-Hasselbalch equation in treating acid-base equilibria in blood plasma.Among the physicochemical constants characterizing an acid, along with its molecular weight, freezing point, and so forth, is to be reckoned its dissociation constant...References References1. LENNONLEMANN EJJ: Defense of hydrogen ion concentration in chronic metabolic acidosis. A new evaluation of an old approach. Ann. Intern. Med. 65: 265, 1966. LinkGoogle Scholar2. HENDERSON LJ: The theory of neutrality regulation in the animal organism. Amer. J. Physiol. 21: 427, 1908. CrossrefGoogle Scholar3. SÖRENSEN SP: Enzymstudien. II. Über die Messung und die Bedeutung der Wasserstoffionenkonzentration bei enzymatischen Prozessen. Biochem. Z. 21: 131, 201, 1909. Google Scholar4. CLARK WM: Topics in Physical Chemistry. A Supplementary Text for Students of Medicine. The Williams & Wilkins Co., Baltimore, 1948. Google Scholar5. HASSELBALCH KA: Die Berechnung der Wasserstoffzahl des Blutes aus der freien und gebundenen Kohlensäure desselben, und die Sauerstoffbindung des Blutes als Funktion der Wasserstoffzahl. Biochem. Z. 78: 112, 1917. Google Scholar6. DEBYEHÜCKEL PE: Zur Theorie der Elektrolyte. I. Gefrierpunktserniedrigung und verwandte Erscheinungen. Physikalische Z. 24: 185, 1923. Google Scholar1. BATES RG: Determination of pH. Theory and Practise. John Wiley and Sons, New York, London, and Sydney, 1964, Chap. 1. Google Scholar2. HUCKABEE WE: Henderson vs Hasselbalch. Clin. Res. 9: 116, 1961. Google Scholar3. ROBERTSPOPPELLVANAMEEBEALSRANDALL KEJWPRHT: Evaluation of respiratory compensation in metabolic alkalosis. J. Clin. Invest. 35: 261, 1956. CrossrefMedlineGoogle Scholar4. POPPELLVANAMEEROBERTSRANDALL JWPKEHT: The effect of ventilatory insufficiency on respiratory compensations in metabolic acidosis and alkalosis. J. Lab. Clin. Med. 47: 885, 1956. MedlineGoogle Scholar5. Report of ad hoc committee on acid-base terminology. Ann. N. Y. Acad. Sci. 133: 254, 1966. (Also reproduced in Ann. Intern. Med. 63: 885, 1965.) Google Scholar6. SEVERINGHAUSSTUPFELBRADLEY JWMAF: Accuracy of blood pH and pCO2 determination. J. Appl. Physiol. 9: 189. 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Section of Metabolism Department of Medicine University of Miami School of Medicine Miami, Fla. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIl centenario del pH (1909-2009) - Parte seconda. Ma era proprio necessario sostituire l’equazione di Henderson con quella di Henderson-Hasselbalch?A Diagram to Facilitate the Understanding and Therapy of Mixed Acid Base DisordersIn defence of pHAn Acid-Base Chart for Arterial Blood with Normal and Pathophysiological Reference AreasAcid-Base Response to Chronic Hypercapnia in Man 1 November 1966Volume 65, Issue 5Page: 1150-1152KeywordsBlood plasma Issue Published: 1 November 1966 PDF DownloadLoading ...