tbuckley/cabot-search huggingface dataset:
The prescriptions frequencies and patterns of Chinese herbal medicine for allergic rhinitis in Taiwan
Authors: Y. Y. Kung, Y. C. Chen, S. J. Hwang, T. J. Chen, F. P. Chen
Journal: Allergy (2006)

The evaluation of Chinese herbal medicines (CHM) to allergic rhinitis (AR) by large-scale pharmaco-epidemiological study is not ease found, although CHM had been reported to have potential effect for AR in some clinical trials.To explore the frequency and pattern of CHM prescriptions on AR, we have the study by analysing the population-based CHM database in Taiwan.The way for this study was linked and processed the complete traditional Chinese medicine database for Taiwanese recorded in the year 2002. The diagnosis of AR was extracted with the only single ICD-9 Code of 477 to calculate the frequency and pattern of prescriptions. Association rule was applied to analyse co-prescription of CHM for patients with AR.In the year 2002, among the 22 520 776 valid beneficiaries of the National Health Insurance, Taiwan, 914 612 subjects (3.8% of the total valid beneficiaries) have diagnosed AR. There were 35.6% of AR patients been treated by CHM. The peak age of AR patients treated by CHM was at the first decade (0-10). For the AR patients, the most common Chinese herbal formula prescription was Shin-yi-qing-fei-tang, or Angelica dahurica (Bai-zhi) for the single Chinese herb. While for the combination treatments the most common prescription was the two formulae, Xiao-qing-long-tang and Shin-yi-san.Because of the high utilization rate of the CHM treatment for AR, a large-scale randomized trial warrants further research for its efficacy and safety.
Sensitive Cardiac Troponin T Assay and the Risk of Incident Cardiovascular Disease in Women With and Without Diabetes Mellitus
Authors: Brendan M. Everett, Nancy R. Cook, Maria C. Magnone, Maria Bobadilla, Eunjung Kim, Nader Rifai, Paul M Ridker, Aruna D. Pradhan
Journal: Circulation (2011)

Very low levels of cardiac troponin T are associated with an increased risk of cardiovascular death in patients with stable chronic coronary disease. Whether high-sensitivity cardiac troponin T levels are associated with adverse cardiovascular outcomes in individuals without cardiovascular disease (CVD) has not been well studied.
Increased reliance on private sector holds dangers for NHS, says report
Authors: Z. Kmietowicz
Journal: BMJ (2012)

Private companies looking to provide health services in England under opportunities created by the Health and Social Care Bill have an inherent conflict of interests between their shareholders and patients that NHS users will have to learn to question, says a campaigning group.

The NHS Support Federation, which describes itself as an independent pressure group that works to protect and promote the principles of the NHS, has looked in detail at the structure and business history of six private companies that currently provide NHS services and at whether there is evidence that this sector can solve the problems of some poorly performing NHS hospitals.

It says in its report that two of the United Kingdom’s largest providers of private inpatient care believe that the pressure on the NHS to make savings will mean a boost for the …
[125] PD-1/PD-L BLOCKADE CAN IMPROVE THE HBV-SPECIFIC T CELL FUNCTION IN CHRONIC HBV INFECTION
Authors: P. Fisicaro, C. Boni, C. Valdatta, A. Bertoletti, S. Schivazappa, T. Giuberti, A. Cavalli, G. Missale, C. Ferrari
Journal: Journal of Hepatology (2007)
Myocardial oxygen consumption at constant left ventricular workload and varying arterial oxygenation1
Authors: A. C. KRALIOS, T. J. TSAGARIS, H. KUIDA
Journal: Cardiovascular Research (1975)

The effect of arterial oxygen content (CaO2) changes on myocardial O2 consumption (MVO2) was studied in dogs with controlled heart rate, cardiac output, and arterial pressure. MVO2 did not change significantly as a result of systemic or selective left coronary CaO2 changes ranging randomly from hypoxaemia to hyperoxaemia.
Abstract 22: Cyclin E amplification, a novel mechanism of resistance to trastuzumab in HER2 amplified breast cancer
Authors: Maurizio Scaltriti, Pieter Eichhorn, Magui Gili, Marta Guzman, Claudia Aura, José Jimenez, Ludmila Prudkin, Simon R. Green, Javier Cortés, Sarat Chandarlapaty, Sabine Mai, Clifford A. Hudis, Neal Rosen, José Baselga
Journal: Cancer Research (2010)

Abstract HER2 amplification/overexpression occurs in 20% of breast cancers and is associated with poor prognosis. Therapeutic agents against HER2, including monoclonal antibodies and tyrosine kinase inhibitors, have shown to improve the survival of these patients. However, primary and acquired resistance to these agents is a major barrier to the effective treatment of this disease. Aiming to identify the molecular pathways responsible for resistance to anti-HER2 therapy we have established HER2 positive breast cancer cell lines refractory to the anti-proliferative effects of the therapeutic antibody trastuzumab. We have studied their acquired genetic aberrations by performing gene expression microarray and genome single nucleotide polymorphisms analyses. In trastuzumab resistant cells we identified an increase in copy number variation in locus 19q12. This chromosome region comprises seven genes, among them cyclin E1 (CCNE1). We further confirmed Cyclin E over-expression in trastuzumab resistant cells by western blot. To test the hypothesis that increased cyclin E expression could play a role in the acquisition of trastuzumab resistance we have demonstrated that ablation of cyclin E expression by siRNA restores trastuzumab sensitivity in HER2 positive resistant cells. Furthermore, we have determined that trastuzumab resistant cells are highly sensitive to the specific CDK inhibitor seliciclib and its more potent derivative Cmpd. 5 (Cyclacel) both in vitro and in vivo. In addition, we have analyzed a cohort of HER2 positive breast cancer patients treated with trastuzumab-based therapy and identified a proportion of patients refractory to trastuzumab that harbor amplification of the cyclin E gene. Our results suggest that cyclin E amplification decreases trastuzumab sensitivity and may provide the rationale to test the efficacy of CDK2 inhibitors in breast cancer patients with cyclin E amplification that escaped trastuzumab therapy. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 22.
The power of cross-linguistic analysis: A key tool for developing explanatory models of human language
Authors: Lynn Santelmann
Journal: Behavioral and Brain Sciences (1999)

Clahsen's compelling evidence for the dual-mechanism model of the lexicon derives in part from the use of cross-linguistic data in psycholinguistic research. This approach reflects a growing (and positive) trend toward incorporating data from several languages when analyzing and modeling human language behavior. This perspective should be expanded to include data from typologically distinct languages to develop more explanatory models of language.
Hair growth inhibition by heparin in mice: a model system for studying the modulation of epithelial cell growth by glycosaminoglycans?
Authors: R. PAUS
Journal: British Journal of Dermatology (1991)

Journal Article Hair growth inhibition by heparin in mice: a model system for studying the modulation of epithelial cell growth by glycosaminoglycans? Get access R. PAUS R. PAUS Department of Dermatology. Yale University School of Medicine. New Haven. CT 06510. U.S.A. Dr R.Paus. Department of Dermatology. University Hospital Rudolf Virchow, Freie Universität Berlin. D‐1000 Berlin 65. Germany. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 124, Issue 5, 1 May 1991, Pages 415–422, https://doi.org/10.1111/j.1365-2133.1991.tb00618.x Published: 01 May 1991
453 Incidence and predictive factors of mutations in the YMDD motif of the HBV polymerase after two years of lamivudine treatment for chronic hepatitis B: Results of the prospective cohort lamivir
Authors: F. Zoulim, T. Poynard, F. Degos, P. Deny, P. Landais, P. Blin, A. El Hasnaoui, A. Slam, P. Parvaz, C. Trepo
Journal: Journal of Hepatology (2004)
Reduced Sexual Activity in HIV-Infected Homosexual Men-Reply
Authors: Jonathan E. Kaplan
Journal: JAMA (1989)

<h3>In Reply. —</h3> Drs Brown and Pace raise interesting questions regarding the reasons why the human immunodeficiency virus (HIV)—infected men in our study, as well as HIV-infected persons in their own studies, have reduced their sexual activity in recent years. We recognize that "personal health concerns" may have had different meanings for the men in our study who reported this as a reason for change in sexual behavior. We do have some data concerning depression in our group of men. Of the 31 men in our study, 24, including 6 of the 7 who reported no sex partners in the 6-month period before the second questionnaire was administered in 1987, were administered measures of affective state, including the Zung Depression Scale, as part of a study of neuropsychiatric complications of HIV infection in 1986.<sup>1</sup>The men were also asked whether they had ever been diagnosed by a physician as
A MODEL OF THE RELATIONSHIP BETWEEN MELANOCYTES AND LANGERHANS CELLS. Melanocyte Population Dynamics
Authors: P. A. RILEY
Journal: British Journal of Dermatology (1967)

Journal Article A MODEL OF THE RELATIONSHIP BETWEEN MELANOCYTES AND LANGERHANS CELLS. Melanocyte Population Dynamics Get access P. A. RILEY, Ph.D., M.B. P. A. RILEY, Ph.D., M.B. Medical Research Council Junior Research Fellow, Department of Dermatology, University College Hospital Medical School, London, W.C.1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 79, Issue 1, 1 January 1967, Pages 52–58, https://doi.org/10.1111/j.1365-2133.1967.tb11397.x Published: 01 January 1967
Avoidance of Surgical Hyperglycemia in Diabetic Patients
Authors: Robert E. Woodruff
Journal: JAMA (1980)

Strict intraoperative glucose level control was accomplished with constant low-dose glucose infusion of 100 mg/kg/hr and variable infusion rates of insulin to control serum glucose levels as follows: 20 units/hr for serum glucose levels greater than 200 mg/dL, 1 unit/hr for levels between 80 and 200 mg/dL, and no insulin for levels less than 80 mg/dL. Using this technique, eight diabetic patients with serum glucose levels greater than 250 mg/dL before surgery had their serum glucose levels brought rapidly under control (ie, glucose level less than 200 mg/dL), which continued postoperatively. (<i>JAMA</i>244:166-168, 1980)
Case 27-1984
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely
Journal: New England Journal of Medicine (1984)

Presentation of Case A 50-year-old man was admitted to the hospital because of bilateral pleural effusions and pedal edema. He was well until 9 1/2 years earlier, when cervical lymphadenopathy developed, with the superior-venacava syndrome. Microscopical examination of a biopsy specimen of a lymph node revealed Hodgkin's disease, nodular-sclerosis type. A staging laparotomy showed involvement of the spleen and a paraaortic lymph node; a clinical stage of IIIB was assigned. Radiation treatment was administered to a mantle field, with delivery of approximately 4000 rad to the mediastinum and the right side of the heart. Chemotherapy with cyclophosphamide, vincristine, procarbazine, prednisone, . . .
Measurement of Cardiac Output by Thermodilution
Authors: Richard D. Weisel, Robert L. Berger, Herbert B. Hechtman
Journal: New England Journal of Medicine (1975)

THE functional assessment of myocardial performance includes a measurement of cardiac output. Such precise diagnostic information is particularly valuable in patients with cardiac disease who are undergoing catheterization or open-heart surgery. In the intensive-care unit, a major goal of treatment for the critically ill is frequently the improvement of myocardial function. Serial determinations of cardiac output in these circumstances can be valuable adjuncts in guiding fluid and drug therapy.Information on cardiac output has not been available for routine clinical use, principally because measurement technics have been difficult and time consuming. Thermodilution methodology obviates many of these technical problems. This . . .
Targeting 2A Protease by RNA Interference Attenuates Coxsackieviral Cytopathogenicity and Promotes Survival in Highly Susceptible Mice
Authors: Sabine Merl, Cornelia Michaelis, Birgit Jaschke, Marc Vorpahl, Stefan Seidl, Rainer Wessely
Journal: Circulation (2005)

Background— Enteroviridae such as coxsackievirus B3 (CVB3) are important infectious agents involved in viral heart disease, hepatitis, and pancreatitis, but no specific antiviral therapy is available. Methods and Results— The aim of the present study was to evaluate the impact of RNA interference on viral replication, cytopathogenicity, and survival. Small interfering RNA (siRNA) molecules were designed against the viral 2A region (siRNA-2A), which is considered to be highly conserved and essential for both virus maturation and host cytopathogenicity. siRNA-2A exhibited a significant protective effect on cell viability mediated by marked inhibition of CVB3 gene expression and viral replication. In highly susceptible type I interferon receptor–knockout mice, siRNA-2A led to significant reduction of viral tissue titers, attenuated tissue damage, and prolonged survival. Repeated siRNA-2A transfection was associated with a further improvement of survival. Various control siRNA molecules had no protective effect in vitro or in vivo. Conclusions— RNA interference directed against the 2A protease encoding genomic region effectively confers intracellular immunity toward CVB3-mediated cell injury and improves survival, suggesting a potential role for RNA interference for future treatment options targeting enteroviral diseases.
A CASE OF PYODERMITE VEGETANTE (HALLOPEAU)
Authors: W. N. GOLDSMITH
Journal: British Journal of Dermatology (1941)

Journal Article A CASE OF PYODERMITE VÉGÉTANTE (HALLOPEAU) Get access W. N. GOLDSMITH W. N. GOLDSMITH Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 53, Issue 11, 1 November 1941, Pages 299–318, https://doi.org/10.1111/j.1365-2133.1941.tb10486.x Published: 01 November 1941
How to manage the transplant question in myelofibrosis
Authors: K Ballen
Journal: Blood Cancer Journal (2012)

Allogeneic stem cell transplantation remains the only curative therapy for myelofibrosis. Despite advances in transplant, the morbidity and the mortality of the procedure necessitate careful patient selection. In this manuscript, we describe the new prognostic scoring system to help select appropriate patients for transplant and less aggressive therapies. We explore the advances in non-transplant therapy, such as with investigational agents. We review the blossoming literature on results of myeloablative, reduced intensity and alternative donor transplantation. Finally, we make recommendations for which patients are most likely to benefit from transplantation.
Rationing and the Americans With Disabilities Act-Reply
Authors: David Orentlicher
Journal: JAMA (1994)

<h3>In Reply.</h3> —Although Dr Kopelman's letter suggests that important differences exist between her views and mine, in fact we are in substantial agreement. The concerns that she mentions reflect a misreading of my article. As Kopelman observes and as I argue, constraints of cost and efficiency should not vitiate the right of persons with disabilities to equality of treatment, and as she suggests, criteria for allocating health care must be articulated openly and subjected to public scrutiny. My article proposes such criteria and indicates how the criteria should be applied. Specifically, I argue that rationing decisions must be justified by legitimate nondiscriminatory factors, and I put forth the five criteria that Kopelman quotes. I do not pretend that these criteria provide a complete guide to rationing, however. The criteria are difficult to quantify and are not as objective and ethically neutral as they appear. For example, treatments for persons with
Health professionals and South Africa: supporting change in the health sector.
Authors: T Waterston, A Zwi
Journal: BMJ (1993)

Now that political change is on the way in South Africa, what should be the position of doctors who are invited to visit the country? Does the "academic boycott" still have relevance? Waterston and Zwi review the case for and against an academic boycott policy, using evidence collected during the recent visit by Physicians for Human Rights (UK) and the Johannes Wier Foundation. The health system in South Africa is still inequitable, and despite progress towards desegregation in hospitals there is little momentum towards universal provision of primary health care, especially in the rapidly growing townships around big cities. The authors consider that pressure on the government should be maintained by outside organisations but that support directed towards appropriate health care should be encouraged, particularly in public health and primary health care.
Increased Risk of Death From Iron Overload Among 422 Treated Probands With HFE Hemochromatosis and Serum Levels of Ferritin Greater Than 1000 μg/L at Diagnosis
Authors: James C. Barton, J. Clayborn Barton, Ronald T. Acton, Jeffrey So, Susanne Chan, Paul C. Adams
Journal: Clinical Gastroenterology and Hepatology (2012)
Chronic Hypoxia Induces Constitutive p38 Mitogen-activated Protein Kinase Activity That Correlates with Enhanced Cellular Proliferation in Fibroblasts from Rat Pulmonary But Not Systemic Arteries
Authors: DAVID J. WELSH, ANDREW J. PEACOCK, MARGARET MacLEAN, MARGARET HARNETT
Journal: American Journal of Respiratory and Critical Care Medicine (2001)

Pulmonary hypertension occurs commonly in patients with chronic hypoxic lung disease and is characterized by the remodeling of the pulmonary artery walls. The molecular mechanisms underlying such remodeling are unknown but we have recently shown that the stress-activated (Jnk and p38) mitogen-activated protein (MAP) kinases are activated in pulmonary artery fibroblasts following acute hypoxia. We now show that Erk and p38 MAP kinases are constitutively activated in fibroblasts derived from the remodeled pulmonary, but not the systemic circulation from rats exposed to chronically hypoxic conditions. Moreover, we find that such fibroblasts show sustained enhanced proliferative capacities relative to pulmonary artery fibroblasts derived from normoxic rats or to aortic fibroblasts from either normoxic or hypoxic rats. Finally, abrogation of p38, but not Erk MAP kinase activity by use of specific inhibitors, prevents the enhanced proliferative capacity exhibited by pulmonary artery fibroblasts. Taken together, these data suggest that enhanced p38 MAP kinase activity provides a molecular mechanism to explain the proliferation of pulmonary artery fibroblasts required for remodeling of the pulmonary vasculature.
Consequences of the AF-2 incident in Japan.
Authors: Y Tazima
Journal: Environmental Health Perspectives (1979)

The discovery of the potent mutagenicity of AF-2, which was once used in Japan as a food preservative, has exerted a great influence not only on screening procedures for carcinogenic compounds but also on legislative approaches to mutagenic substances. It promoted the synthesis of exceedingly sensitive and reliable tester strains in Salmonella and supported the hypothesis of a common mechanism between mutagenicity and carcinogenicity. Thus preliminary screening for carcinogenic substances has become feasible using mutagenicity as an index. It also contributed greatly to the formulation of legislative measures for chemical substances which for the first time gave due attention to mutagenicity. Furthermore, the exposure of a large population to such a potent mutagen raised a question as to what extent the genetic constitution of the Japanese population might have been damaged. This suggested that urgent need for a system to monitor the total genetic damage to a human genome.
Abstract 3811: The receptors-independent anti-cancer effect of anandamide in head and neck squamous cell carcinoma cells
Authors: Seok-Woo Park, Myung-Whun Sung
Journal: Cancer Research (2012)

Abstract It has been suggested that endocannabinoids, anandamide (AEA) and 2-arachidonoyl glycerol (2-AG), might be the promising anti-cancer agents in clinical fields of cancer treatment. In this study, we tried to check the anti-cancer effects of AEA and 2-AG in head and neck squamous cell carcinoma (HNSCC) cell lines. AEA inhibited effectively cell proliferation of three HNSCC cells (SNU-1041, 1066 and 1076) but 2-AG did not. Cannabinoid receptor-1 (CB1) was expressed only in SNU-1066 and expression of VR1 was observed in all tested cells (no CB2 was detected). Anti-cancer effect of AEA seemed to be mediated by their receptors-independent action since the antagonist of CB1 and VR1 (AM251, cay10448 and capsazepine) did not reverse AEA-inhibited cell proliferation. From references on cancer-cell killing effect of COX-2 metabolites of AEA in some types of cancer such as colon cancer, we checked the possibility of COX-2-mediated anti-cancer effect of AEA in HNSCC cells but COX-2 inhibition (by its inhibitors and siRNA) had no effect on it. Instead, we observed the increase of reactive oxygen species (ROS) and 8-isoprostane production by AEA and antioxidants (NAC and ebselen) reversed AEA-inhibited cell proliferation partially. In addition, AM404 and cay10412 (inhibitors of AEA transporter) reversed perfectly AEA-inhibited cell proliferation. These findings suggest that AEA might have anti-cancer effect by their receptors-independent action in intracellular localization of HNSCC cells (such as increase of ROS). The investigation on detailed mechanism of anti-cancer action of AEA in HNSCC cells is ongoing. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3811. doi:1538-7445.AM2012-3811