tbuckley/cabot-search huggingface dataset:
Impact of antipsoriatic therapy on endothelial function
Authors: E. Cohen-Barak, M. Sah, M. Kerner, D. Rozenman, M. Ziv
Journal: British Journal of Dermatology (2015)

Endothelial function (EF) impairment is one of the first events in the process of atherosclerosis, which is known to be associated with psoriasis. Nevertheless, the effect of antipsoriatic treatments, some of them with atherogenic risks, on cardiovascular morbidity and EF is still unclear.To investigate the effect of short-term antipsoriatic treatments on EF values as a potential marker of their effect on cardiovascular morbidity.EF was evaluated in 26 patients with moderate-to-severe psoriasis by measuring microvascular blood flow, expressed as the reactive hyperaemia index (RHI), before and after phototherapy (8 weeks) or systemic antipsoriatic treatment (12 weeks).Antipsoriatic intervention was effective (46% achieving ≥ 75% improvement in Psoriasis Area and Severity Index), while the average RHI did not improve during the study (1·73 ± 0·48. vs. 1·66 ± 0·35, average difference -0·12 ± 0·43, not significant). Patients with baseline preserved EF exhibited a decline in RHI (difference -0·2 ± 0·4, P = 0·053), while patients with abnormal baseline RHI presented nonsignificant RHI improvement (RHI difference 0·1 ± 0·2).There was no positive effect on EF of short-term antipsoriatic treatment. It is possible that a longer period of treatment and EF evaluation would uncover a positive endothelial effect, especially in patients with baseline abnormal EF.
The Dangers of Cooking With Bay Leaves
Authors: Patt E. Panzer
Journal: JAMA (1983)

<h3>To the Editor.—</h3> In a recent issue ofThe Journal(1983;249:729), an interesting letter was brought to my attention. It recounts the case histories of a patient who experienced a ruptured Meckel's diverticulum and of another who experienced severe rectal pain, with the causative agent being the villainous bay leaf. It seems that I am a more fortunate victim of this "deadly" condiment. I am currently a firstyear family practice resident. Back in October 1982,I happened to be on call for the final night of my general surgery rotation. That evening I was ravenous after spending all day in the operating room. Chicken cacciatore was the feature at the hospital cafeteria. As I eagerly swallowed my first (and only) bite, to my dismay, what felt like a small chicken bone had lodged in my throat. Despite my repeated attempts to dislodge the thing, it would not budge in either direction.
Chemical Sensitivity: the Truth About Environmental Illness
Authors: A. Dally
Journal: BMJ (1998)

Stephen J Barrett, Ronald E Gots

Prometheus Books, =A323, pp 212

ISBN 1 57392 195 5

Environmental damage to health is highly topical. Newspapers carry horror stories about things in the environment causing cancer, heart attacks, or early death, yet reliable reference books are hard to find. What evidence is there for and against, say, allergy to various foods, chronic fatigue syndrome, or Gulf War syndrome?

Throughout civilisation people have been troubled by multiple symptoms for which, unable to find …
Thrombotic complications in essential thrombocythemia with relatively low platelet counts
Authors: Arie Regev, Pinhas Stark, Dorit Blickstein, Meir Lahav
Journal: American Journal of Hematology (1997)

Essential thrombocythemia (ET) is often associated with thrombotic and hemorrhagic complications, mostly at platelet counts exceeding 600 x 10(9)/L. There are, however, a few reports of such complications in ET at considerably lower platelet levels and the therapeutic approach to affected patients with relatively low platelet counts is still controversial. In the present study, the first to directly address the issue of hemostatic manifestations at relatively low platelet counts, we have determined the lowest platelet counts associated with such manifestations in 56 consecutive ET patients. Clinical manifestations related to ET were recorded in 46 (82%) patients. Of the symptomatic patients, 32 (70%) had symptoms at platelet counts lower than 600 x 10(9)/L, 23 (50%) at counts lower than 500 x 10(9)/L, 10 (22%) at counts lower than 400 x 10(9)/L, and 6 patients (13%) at platelet counts as low as 300-350 x 10(9)/L. Severe complications occurred at platelet counts lower than 600 x 10(9)/L in 10 patients (22%), lower than 500 x 10(9)/L in 7 (15%), and at lower than 400 x 10(9)/L in 2 (4%). Thrombotic neurologic symptoms were the most common (31 patients, 67%), followed by peripheral vascular symptoms (17 patients, 37%); hemorrhagic complications were relatively rare (3 patients, 7%). In most cases, cessation or improvement of clinical manifestations was observed only after further reduction in platelet counts. In conclusion, thrombotic manifestations, including severe ones, are not uncommon in ET at relatively low platelet counts. We recommend that symptomatic patients with relatively low platelet counts be treated and the platelet counts further reduced well into the lower normal range.
The caring profession
Authors: A. Gregan
Journal: BMJ (1997)

I cannot remember exactly why I wanted to become a doctor but whatever your reason the end result is the same, to discharge a duty of care towards the patient to the best of your ability. Every doctor also has a responsibility to his fellow professionals not to bring the profession into disrepute. Doctors' duties towards their patients and responsibilities to the profession are clear and accepted but what of the profession's duties and responsibilities towards doctors?

From the moment that I walked through the medical school gates I was engulfed by the medical world with student BMA membership and Medical Defence Union sponsored tee shirts. Once I qualified the parochial nature of the profession became even more evident. Closeted from the rest of society by the jargon of health care, safe in the knowledge that I had a job for life and financial security with a respected position in society, it became hard and unnecessary to imagine a life outside medicine. I had merged gratefully and seamlessly with the thousands of other junior doctors eating, drinking, and …
Training for Internal Medicine and Emergency Medicine
Authors: Jerris R. Hedges
Journal: JAMA (1988)

To the Editor.  —I wish to address a point of semantics that is of potential importance to general internal medicine residency educators, medical school administrators, and health care administrators who may read the article by McPhee et al 1 entitled Training in a Primary Care Internal Medicine Residency Program: The First Ten Years. McPhee et al surveyed their general internal medicine residency graduates to determine the graduates' impressions of the adequacy and relevance of their training in different practice disciplines. The authors mistakenly listed emergency medicine as an internal medicine discipline. In doing so, they create the potential for misinterpretation of their data.  Emergency medicine is a practice specialty that draws much of its body of knowledge from other specialties—including internal medicine. There is no indication from the training or career pathway information provided by the authors that their graduates had either training in emergency medicine or practice this specialty.
The Effect of Universal Influenza Immunization on Mortality and Health Care Use
Authors: Jeffrey C Kwong, Thérèse A Stukel, Jenny Lim, Allison J McGeer, Ross E. G Upshur, Helen Johansen, Christie Sambell, William W Thompson, Deva Thiruchelvam, Fawziah Marra, Lawrence W Svenson, Douglas G Manuel
Journal: PLoS Medicine (2008)

In 2000, Ontario, Canada, initiated a universal influenza immunization program (UIIP) to provide free influenza vaccines for the entire population aged 6 mo or older. Influenza immunization increased more rapidly in younger age groups in Ontario compared to other Canadian provinces, which all maintained targeted immunization programs. We evaluated the effect of Ontario's UIIP on influenza-associated mortality, hospitalizations, emergency department (ED) use, and visits to doctors' offices.
Postoperative Compressive Neuropathies
Authors: Carl J. Belber
Journal: JAMA (1982)

To the Editor.—  The development of postoperative compressive neuropathies—ulnar, radial, and peroneal—in our series was related not only to prolonged compression of several hours, but also, in every instance, to a chronic, dense neuroma in continuity. There is no doubt that the short-term compression was the proximate cause of the neuropathy but, from the operative evidence, the preexisting chronic neuroma would appear to be an essential cofactor; in other words, an already partly anatomically compromised—but fully functional— nerve was pushed over the edge by a compressive stress, causing an acute neuropathy.  Therefore, in contrast to the outlook promoted by John F. Aita, MD (1981;245:2295), stating that these patients have a poor prognosis... whether treated medically or surgically with transposition or decompression and suggesting that treatment is limited to counseling the patient, I would urge physicians to look at this lesion in a more positive way.  In my experience, during a
Daily respiratory mortality and PM10 pollution in Mexico City
Authors: M.M. Téllez-Rojo, I. Romieu, S. Ruiz-Velasco, M-A. Lezana, M-M. Hernández-Avila
Journal: European Respiratory Journal (2001)

From the authors: 

We would like to thank Filleul et al. 1 for their thoughtful comments on our paper 2 which discusses some limitations of time-series analyses.

The main objective of our study was to evaluate the impact of air pollution on respiratory mortality accounting for primary and underlying causes of death, as accounting for primary causes only may underestimate the real impact of air pollution on respiratory death. We also aimed at obtaining a better specification of individual exposure by stratifying by place of death; the rationale being that the relationship between air pollution and death should be more apparent in subjects dying outside of medical units. Our data show that by considering these two factors, we were able to better capture the impact of air pollution on respiratory health.

Filleul et al. …
A Profile of the Health-Promoting Behaviors of Physicians and Lawyers
Authors: Grace Wyshak, George A. Lamb, Robert S. Lawrence, William J. Curran
Journal: New England Journal of Medicine (1980)

The federal government has increased its activities directed toward health promotion and disease prevention.* We carried out a pilot survey of a random sample of Massachusetts physicians and lawyers to obtain a profile of the personal health-promoting behaviors in the two professional groups.MethodsA questionnaire was sent to random samples of lawyers from the 1978 roster of the Massachusetts Board of Bar Examiners and of physicians from the 1978 computerized list of licensed and registered physicians in the state, obtained from the Massachusetts Department of Public Health. We used a random-number generator to select the samples. Out-of-state residents appearing . . .
The Neurological Assessment of the Preterm and Full-Term Newborn Infant
Authors: Ira Bergman
Journal: JAMA (1982)

This book is a well-written, concise but thorough, up-to-date summary of the methods of the neurological and developmental examination in the preterm and full-term neonate. The methods are organized in a practical fashion, and it is clear that the authors have spent a great deal of time in a functioning neonatal unit practicing their techniques. They have pared the examination down to its essentials and explain well the purpose of all the parts. They also explain why they have omitted previously standard portions of the examination. Each element of the examination is elucidated by text, illustrations, and pictures. Care has been taken to appose pictures and illustrations closely with their corresponding text, thereby optimizing readability and understanding. Both technique for eliciting responses and variations in expected responses are explained in depth. Allowance is made for the unusual or idiosyncratic response. The authors stress the influence of the state of the
Experimental Treatment of Ethylene Glycol Poisoning
Authors: Donald I. Peterson, John E. Peterson, Mervyn G. Hardinge, Warren E. C. Wacker
Journal: JAMA (1963)

ETHYLENE GLYCOL has been widely used as a solvent for dyes and drugs and as a constituent of antifreeze mixtures for the cooling systems of automobiles.<sup>1</sup>Forty to 60 deaths are thought to occur annually from accidental ingestion or from its use as a substitute for beverage alcohol.<sup>2</sup>The fatal dose in human adults is believed to be about 100 gm.<sup>3</sup> Initially, the toxic manifestations of ethylene glycol poisoning relate to central nervous disorder with confusion, convulsions, and coma occurring commonly. Other evidence of neuropathy such as incoordinate movement, ataxia, and ocular palsy may occur. The early symptoms are not unlike those of acute intoxication with ethanol. These symptoms are sometimes associated with signs of cardiopulmonary disease. Tachycardia, tachypnea, cyanosis, and pulmonary edema have been observed early in the course of illness.<sup>4</sup>Later, however, there is evidence of nephrotoxicity.<sup>4,5</sup>Blood and protein are found in
Physicians Behaving Badly
Authors: Michael D Stillman
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma
Authors: R Wagener, L B Alexandrov, M Montesinos-Rongen, M Schlesner, A Haake, H G Drexler, J Richter, G R Bignell, U McDermott, R Siebert
Journal: Leukemia (2015)

Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma
Treatment of Thyrotoxic Hypercalcemia with Propranolol
Authors: Robert K. Rude, Susan B. Oldham, Frederick R. Singer, John T. Nicoloff
Journal: New England Journal of Medicine (1976)

A noteworthy elevation in mean total and ionized serum calcium concentration has previously been documented in hyperthyroidism.1 2 3 Numerous cases of overt hypercalcemia in hyperthyroidism also have been reported,4 the frequency being at least 8 per cent.3 The degree of hypercalcemia is usually mild. Occasionally, however, patients have symptoms attributable to hypercalcemia, and acute therapy to lower the serum calcium is indicated. The usefulness of propranolol in correcting the hypercalcemia of hyperthyroidism was evaluated in the following two patients with this condition.MethodsPatientsA 24-year-old woman (Case 1) and a 64-year-old woman (Case 2) gave similar histories of weight loss, weakness, . . .
Drugs Five Years Later: Praziquantel
Authors: Charles H. King
Journal: Annals of Internal Medicine (1989)

Purpose: To identify advances in knowledge of the pharmacokinetics, mechanism of action, clinical use, and side effects of the antihelminthic drug praziquantel in the 5 years since its introduction in the United States. Data Identification: Studies reported from 1983 to July 1988 were identified by computer searches of MEDLINE and TOXLINE, and review of textbooks and review articles. Study Selection: Of 57 articles originally identified, 39 were selected by two readers. Data Extraction: Study quality and significance were independently assessed by each reader. Results of Data Analysis: The pharmacokinetics and clinical efficacy of praziquantel have been well documented. Yet, despite extensive in vivo and in vitro laboratory studies, the drug's mechanism of action in killing parasites is unknown. Although the efficacy of praziquantel was first established for treating schistosomiasis, in the last 5 years its clinical use has been expanded to the treatment of intestinal, tissue, and lung flukes, and intestinal and tissue cestode infections, including neurocysticercosis. The introduction of praziquantel was a significant advance in antihelminthic therapy, in that it was effective therapy for several parasites that had been previously considered untreatable. Availability of a safe, effective broad-spectrum oral antihelminthic agent consolidated the central role of chemotherapy in population-based control of many trematode and cestode parasites. Randomized trials have shown, however, that older, cheaper agents may be more cost-effective in controlling Schistosoma mansoni and Schistosoma haematobium in some endemic areas. Conclusions: Although praziquantel is the treatment of choice for most human trematode and cestode infections, cost factors have limited its use in developing countries.
Disseminated cholesterol embolism presenting as neuromyelitis optica.
Authors: M Goldman, F Rickaert, P Voordecker, S Goldman, J Flament-Durand
Journal: BMJ (1987)

CommentThis patient had subacute encephalitis, the commonest neurological manifestation of AIDS,23 which is characterised initially by mild cognitive changes and psychomotor retardation.Analysis of cerebrospinal fluid may show a mild pleocytosis, a rise in protein concentration, and a lowered glucose concentration.The prevalence of ophthalmological signs in AIDS is at least 50% and is higher in those studied at necropsy.45The commonest findings are microaneurysms, haemorrhages in the nerve fibre layers, and focal non-perfusion of small retinal vessels, producing cotton wool spots.These abnormalities are probably due to a microvascular retinopathy.Other intraocular complications include cytomegalovirus retinopathy, Roth's spots, and ocular candidiasis.Our patient's ophthalmological signs were caused by ischaemia of the optic nerve head from affected posterior ciliary arteries.The localised areas of fluorescein staining of the retinal veins suggest that the retinal circulation was also affected.
939 WHO MAY HAVE TREATMENT BENEFITS WITH FIBRATES IN PRIMARY BILIARY CIRRHOSIS: A SINGLE CENTER RETROSPECTIVE OBSERVATIONAL COHORT ANALYSIS
Authors: A. Komori, M. Nakamura, Y. Aiba, Y. Kugiyama-Yasunaga, S. Bekki, R. Sasaki, S. Hashimoto, M. Ootani, S.-K. Bae, A. Saeki, S. Nagaoka, S. Abiru, K. Yamasaki, H. Ishibashi, H. Yatsuhashi
Journal: Journal of Hepatology (2013)
Medicine in Chinese Cultures: Comparative Studies of Health Care in Chinese and Other Societies
Authors: Ilza Veith
Journal: JAMA (1977)

It is difficult to discuss this book as a cohesive entity, as it consists of 49 individual articles, including an introduction and an epilogue, and discussions of various papers by 33 participants in this interesting symposium. But those readers who are interested in the subject of Chinese medicine and medicine in China will find in this collection much rewarding information offered by well-known writers on the subject who congregated for the conference from all over the world. I would especially note the last publication of Dr Irene Täuber, the famous demographer and anthropologist of Princeton University, whose death occurred even before the book was published. Her contribution on "Health, Mortality and Population Growth of the Peoples Republic of China" is a worthy monument of her many productive years of research into the life and customs of the peoples of the Far East. Of great importance and interest also are the
DETECTION OF STABLE MYOCARDIAL ISCHEMIC SEGMENTS CONFIRMED ON INVASIVE FRACTIONAL-FLOW-RESERVE USING A NOVEL MULTI-LAYER LONGITUDINAL-STRAIN ASSESSED BY TWO-DIMENSIONAL SPECKLE TRACKING ECHOCARDIOGRAPHY
Authors: Takeshi Nishi, Nobusada Funabashi, Koya Ozawa, Masayuki Takahara, Hiroyuki Takaoka, Yoshihide Fujimoto, Yoshio Kobayashi
Journal: Journal of the American College of Cardiology (2015)
Impaired VE-Cadherin/β-Catenin Expression Mediates Endothelial Cell Degeneration in Dilated Cardiomyopathy
Authors: Romana Schäfer, Dietmar Abraham, Patrick Paulus, Roland Blumer, Michael Grimm, Johann Wojta, Seyedhossein Aharinejad
Journal: Circulation (2003)

The cross-talk between vascular endothelial growth factor (VEGF)-A, angiopoietin (Ang), and VE-cadherin coregulates endothelial cell (EC) survival. Cardiac expression of VEGF-A but not its receptor KDR is blunted in dilated cardiomyopathy (DCM). Whether VE-cadherin/Ang function is affected in DCM is unknown.The myocardial expression of VE-cadherin/beta-catenin, Ang-1, Ang-2, and their receptor Tie-2 was examined in DCM, ischemic cardiomyopathy (ICM), and in control subjects through the use of real-time RT-PCR, Western blotting, and immunocytochemistry. EC degeneration was quantified by TEM. RNA interference against VE-cadherin and VEGF deprivation and stimulation were applied to cultured DCM myocardium and human microvascular ECs to examine the interplay between VEGF, VE-cadherin/beta-catenin, and Ang-2. Analysis of tissue sections with similar rates of EC degeneration in both patient groups showed that VE-cadherin/beta-catenin expression was downregulated in DCM only (P<0.05). Although Ang-1 was not changed, Ang-2 expression was downregulated and Tie-2 protein expression was upregulated both in DCM and ICM (P<0.05). The ratio of degenerated to normal ECs was significantly higher in DCM versus ICM (P<0.05). Targeted VE-cadherin gene silencing in cultured human ECs resulted in similar degenerative effects observed in myocardial ECs of DCM patients. In vitro experiments indicated that VE-cadherin/beta-catenin expression is independent of VEGF.These results indicate for the first time that the EC survival is impaired in myocardium of patients with DCM involving VE-cadherin/beta-catenin, probably independent of VEGF. Targeting VE-cadherin might be of benefit to counteract the selective EC pathology in DCM.