tbuckley/cabot-search huggingface dataset:
Roles of metallothionein and related proteins in metal metabolism and toxicity: problems and perspectives.
Authors: D H Petering, B A Fowler
Journal: Environmental Health Perspectives (1986)

This summary examines some of the known and hypothesized roles of metallothionein and related proteins in mediating the metal metabolism and toxicity from a chemical perspective. It attempts to examine in kinetic terms how such molecules may exert homeostatic control over the intracellular bioavailability of metal ions to essential enzymatic or other molecular systems. The concept of ongoing competition between metallothionein and related proteins with other intracellular metal-binding sites for various metals is also examined in relation to the thermodynamic stability of these proteins. Comparisons between mammalian metallothionein and analogous nonmammalian proteins demonstrate both similarities and great differences in types of metal-binding sites, metal-binding constants, amino acid composition, and secondary structures such that apparent diversity of these low molecular weight metal-binding molecules in nature appears to be growing ever wider. The potential value of these data rests both in delineating new hypotheses for metallothionein evolution and in suggesting new model systems for discovering the normal function of metallothionein and related proteins in cells.
A case of primary anetoderma in an infant
Authors: H-J. Yu, H. Shin, M-S. Kang, J-S. Kim
Journal: British Journal of Dermatology (2007)

Conflicts of interest: none declared. Sir, Anetoderma is a rare cutaneous disorder characterized by a localized depression or outpouching of the skin caused by laxity and weakening of the dermal connective tissue as a result of focal loss of elastic fibres.1 2–3 It is sometimes not associated with any underlying disease [primary (idiopathic) anetoderma] or it can be related to many kinds of dermatoses (secondary anetoderma).1 2–3 In the past, cases of primary anetoderma were classified into the Jadassohn–Pelizzari type, following erythema or urticaria, and the Schweninger–Buzzi type with no preceding inflammatory skin lesions.1 2–3 Currently, this classification is becoming less important because, whether or not one can recognize this feature, it is only an individual variable, not a disease‐defining feature.1 2–3 Anetoderma occurs mainly in middle‐aged women, often in children and rarely in infants.1, 2, 4 We report an interesting case of primary anetoderma, the Schweninger–Buzzi type, which occurred in a 1‐month‐old infant. To our knowledge, this is the youngest reported age of onset of a case that is not congenital.
Abstract 1971: Genome-wide Association Study Identifies Novel Genomic Regions Associated With Drug-induced Long Qt Syndrome
Authors: S Kaab, M D Ritchie, D C Crawford, M Sinner, P J Kannankeril, A A Wilde, C Bezzina, E Schulze-Bahr, P Guicheney, N Bishopric, J J Schott, A Pfeufer, Y Nakamura, T Tanaka, C R Ingram, S Carter, Y Bradford, A L George, D M Roden
Journal: Circulation (2009)

Introduction A serious side-effect of antiarrhythmic and many other agents is drug-induced long QT syndrome (diLQTS) with torsades de pointes. To test the role of common genetic variation in diLQTS...
Diagnosis of Viral Infections of the Central Nervous System
Authors: Cinnia Huang, Nando K. Chatterjee, Leo J. Grady
Journal: New England Journal of Medicine (1999)

To the Editor: The polymerase chain reaction (PCR) is now the preferable method of detecting infections of the central nervous system due to herpesvirus.1 It is at least as good as cell culture for detecting such infections caused by enteroviruses.2 There is, however, limited information on the usefulness of this technology when it is applied to arboviral infections or on the use of a battery of PCR tests against a broad range of viruses.3 Since July 1997, we have been studying these issues. The initial set of PCR assays we used was designed to be applied to cerebrospinal fluid or . . .
Attorney general is to intervene in case of expert witness immunity
Authors: Clare Dyer
Journal: BMJ (2006)

The attorney general, the senior law officer for England and Wales, is to intervene in the General Medical Council's forthcoming appeal against a high court ruling that expert witnesses are immune from disciplinary proceedings over their courtroom evidence.

Lord Goldsmith has asked the Court of Appeal for permission to argue at the hearing, which starts on 10 July, that giving witnesses immunity would be against the public interest.

Mr Justice Collins ruled last February that Roy …
Vaccination policies: individual rights v community health
Authors: S. King
Journal: BMJ (1999)

how much evidence do we need that skilled home nursing available round the clock would be a good idea?For commissioners of care making difficult decisions on resource allocation amid competing priorities will the results of the study we publish today help them decide how best to organise palliative care services?They may note the pointers toward improved outcomes when such a service is provided but also reflect on the difficulties inherent in providing the service on a time limited basis.They may wish to be careful that funding for improving home palliative care along these lines does not come from the same pot as that which pays for the home care services which will carry on if needed when the two weeks is up.But in balancing the benefit to be had from this possible intervention compared with others they will have to fall back on wisdom, compassion, and a broad and inclusive conception of the role of health care services in reducing human suffering.
Abstract P3-14-02: Should patients with comedo ductal carcinoma in situ (DCIS) be managed as if they have locally invasive breast cancer?
Authors: Robert O Dillman, Stephanie E McClure, Francis S Heinemann
Journal: Cancer Research (2012)

Abstract Withdrawn by Author Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P3-14-02.
ROLE OF LEFT ATRIAL RESERVOIR DYSFUNCTION IN PATHOPHYSIOLOGY OF DIASTOLIC HEART FAILURE
Authors: Hidemichi Kouzu, Satoshi Yuda, Junichi Nishida, Naohiro Funayama, Atsushi Mochizuki, Maki Ichimura, Takahiro Doi, Hitomi Yamamoto, Atsuko Muranaka, Nobuaki Kokubu, Noriyuki Fujii, Shinya Shimoshige, Mamoru Hase, Akiyoshi Hashimoto, Kazufumi Tsuchihashi, Naoki Watanabe, Kazuaki Shimamoto
Journal: Journal of the American College of Cardiology (2010)
Postural Substitution in Duchenne's Muscular Dystrophy
Authors: Irwin M. Siegel
Journal: JAMA (1982)

<h3>To the Editor.—</h3> Standing is almost a completely passive act. The line of gravity must fall behind the center of rotation of the hips, in front of the knees and ankles, and within the base of support. Stability of the hips is normally accomplished by balancing the force of gravity posteriorly, against the iliofemoral ligament anteriorly. The gravitational force is restrained by the posterior ligaments and capsule at the knee and by some contraction of triceps surae at the ankle.<sup>1</sup> Walking requires coordinated lower extremity muscle activity. Patterns of substitution in diseases with selective muscle loss can occur. This has been observed in conditions such as poliomyelitis. Duchenne's muscular dystrophy (DMD) is characterized by loss of hip and knee extensor power, accompanied by hip flexion and abduction contracture and ankle equinus. By age 7 years, the majority of such patients show discernible quadriceps weakness, and most stop walking between
Optic nerve disease and injury: Prospects for induction of regeneration
Authors: Michal Schwartz, David L. Hirschberg, Eti Yoles, Arieh Solomon, Michael Belkin, Shoshana Eitan, Vered Lavie, Anat Faber-Elman, Pierre Beserman, Orly Spiegler
Journal: Progress in Retinal and Eye Research (1996)
BLOOD TRANSFUSION INCREASES MORTALITY INDEPENDENT OF HEMOGLOBIN LEVELS IN ELDERLY PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Ricardo Escarcega Alarcon, Michael Lipinski, Nevin Baker, Sa'ar Minha, Marco Magalhaes Pereira, Joshua Loh, Lakshmana Pendyala, Alfazir Omar, Hideaki Ota, Rebecca Torguson, Fang Chen, Jose Rodriguez-Weisson, Petros Okubagzi, William Suddath, Itsik Ben-Dor, Lowell Satler, Augusto Pichard, Ron Waksman
Journal: Journal of the American College of Cardiology (2014)
Brian John McDougall Duxbury
Authors: N K Shinton
Journal: BMJ (2006)

served in the Royal Army Medical Corps in Normandy, Belgium, and Rhodesia before joining his brother in general practice in Bellshill in industrial Lanarkshire.After retirement in 1978 he did locum work.He was chairman of Lanarkshire Medical Committee for 12 years.In addition to an avid interest in politics, sport, crosswords, and puddings, he supplied family, friends and neighbours with plants annually, and grew show chrysanthemums, winning many prizes locally and nationally.He was chairman of the Scottish Chrysanthemum and Dahlia Society for many years.David survived cancer three times.
Dyspepsia and its Treatment by Antiseptics
Authors: G. Rankin
Journal: BMJ (1902)

the frequent coexistence of secondary ulceration of the -stomach or duodenum.In the case of large tumours medicinal measures are useless, and recourse must be had to gastrotomy.In the cases recorded by Thornton and Sch6n- born the concretions were successfully removed after the nature of the tumour had been ascertained by an exploratory incision, while in that related by Schreiber a correct dia- gnosis of bezoar was made from the history and general -features of thecase.
THE BENT BACK OF SOLDIERS
Authors: A. F. Hurst
Journal: BMJ (1918)

In the present experiments, we characterized the action of human/rat corticotropin-releasing factor (h/rCRF) and acute stress (1 hr of immobilization) on hippocampus-dependent learning and on synaptic plasticity in the mouse hippocampus. We first showed that h/rCRF application and acute stress facilitated (primed) long-term potentiation of population spikes (PS-LTP) in the mouse hippocampus and enhanced context-dependent fear conditioning. Both the priming of PS-LTP and the improvement of context-dependent fear conditioning were prevented by the CRF receptor antagonist [Glu<sup>11,16</sup>]astressin. PS-LTP priming and improved learning were also reduced by the protein kinase C inhibitor bisindolylmaleimide I. Acute stress induced the activation of Ca<sup>2+</sup>/calmodulin-dependent kinase II (CaMKII) 2 hr after the end of the stress session. The CaMKII inhibitor KN-62 antagonized the stress-mediated learning enhancement, however, with no effect on PS-LTP persistence. Thus, long-lasting increased neuronal excitability as reflected in PS-LTP priming appeared to be essential for the enhancement of learning in view of the observation that inhibition of PS-LTP priming was associated with impaired learning. Conversely, it was demonstrated that inhibition of CaMKII activity reduced contextual fear conditioning without affecting PS-LTP priming. This observation suggests that priming of PS-LTP and activation of CaMKII represent two essential mechanisms that may contribute independently to long-term memory.
The Biochemistry of Clinical Medicine
Authors: Kurt Stern
Journal: JAMA (1970)

In this age of automation, computerization, and increasingly sophisticated instrumentation of laboratory medicine, the fourth edition of this book continues to provide the nonspecialist with instruction and guidance in the vast and complex field of biochemical physiopathology. The subject is presented on three levels: structure and metabolism of basic constituents (proteins, carbohydrates, lipids, nucleic acids); physiologic chemistry of specific organs (eg, kidney, liver, endocrine glands); important disease entities (diabetes, nephritis, gout, etc). To survey this huge material and bring it nearly up to date is no mean achievement for a single author. Hence, minor blemishes should not be held against him, such as failure to mention IgE among the classes of immunoglobulins. The general approach resembles that of a teacher addressing his brighter students with the intent of stimulating them to see more than one side of an argument. Many purely clinical aspects are discussed in detail, with the author
Women, Inequality, and the Burden of HIV
Authors: Bisola O Ojikutu, Valerie E Stone
Journal: New England Journal of Medicine (2005)

Driving through KwaZulu-Natal, South Africa, one is struck by the lush farmland and beautiful coast, write Drs. Bisola Ojikutu and Valerie Stone. Beyond this panorama, however, lie rural communities with high unemployment and rampant violence, where 40 percent of women seeking prenatal care are positive for HIV.
THE REMOVAL OF BITS OF STEEL FROM THE INTERIOR OF THE EYE, BY THE HAAB MAGNET, WITHOUT INCISION IN THE SCLERA.
Authors: MYLES STANDISH
Journal: JAMA (1902)

The object of this paper is to report a series of eight cases, occurring in my service at the Massachusetts Charitable Eye and Ear Infirmary, in which a long, slender-pointed bit of steel was driven through the cornea and lens and was removed without making an incision in the sciera. The undesirability of such an incision is manifest to everyone, as injury to the choroid and retina is unavoidable. In all these cases; by the use of the Haab magnet, the foreign body was compelled approximately to retrace the track by which it entered the eye. It is true that if the bit of steel does not become impacted in the fundus of the eye, it will fall to the bottom of the vitreous chamber, so that in retracing its course to the pupil it may encounter the lens at a different point from that through which it entered. In
Inhaled nitric oxide (NO) for the treatment of early allograft failure after lung transplantation
Authors: G. I. Kemming, M. J. Merkel, A. Schallerer, O. P. Habler, M. S. Kleen, M. Haller, J. Briegel, C. Vogelmeier, H. Fürst, B. Reichart, B. Zwissler
Journal: Intensive Care Medicine (1998)
Only few workers exposed to wood dust are detected with specific IgE against pine wood
Authors: T. A. Skovsted, V. Schlünssen, I. Schaumburg, P. Wang, P. Staun‐olsen, P. S. Skov
Journal: Allergy (2003)

Background: Our aim was to investigate the frequency of pine allergy in woodworkers with respiratory symptoms and to identify high molecular weight allergens in pine wood extracts. Methods: In a cross‐sectional study we examined work‐related respiratory symptoms in 2033 furniture workers and 474 controls by questionnaires. Clinical examination was performed in 365 wood dust exposed and 116 nonexposed subjects. Blood samples were collected for measuring pine‐specific immunoglobulin (Ig)E by an immunoassay and Western blots. Results: Eleven exposed and three nonexposed subjects had pine‐specific IgE. In the group with clinically defined asthma eight persons (5.4%) had pine‐specific IgE compared with six persons (1.8%) in the group without asthma ( P &lt; 0.05). In the groups with and without respiratory symptoms, 13 (3.8%) and one (0.7%) subject, respectively, had pine‐specific IgE ( P = 0.06). Western blots demonstrated pine‐specific IgE to components in the molecular range of 14 – 100 kD in eight samples (all wood dust exposed). Five samples had pine‐specific IgE against components in a 43 – 59 kD zone and against two bands at 27 and 29 kD that are candidates for major allergens. Conclusion: Some workers in the Danish furniture industry are specific IgE sensitized against pine wood dust. Pine‐specific IgE probably explains a minor part of the respiratory symptoms in workers exposed to pine wood dust.
127 Beta-blockers in the prevention of aggravation of esophageal varices in patients with cirrhosis and small varices: a placebo-controlled clinical trial
Authors: C MERKEL, R MARIN, P ANGELI, P ZANELLA, M FELDER, E BERNARDINELLO, G CAVALLARIN, M BOLOGNESI, C DONADA, P TORBOLI
Journal: Hepatology (2003)
Correlation of GM-CSF mRNA in bronchoalveolar fluid with indices of clinical activity in sarcoidosis.
Authors: A Itoh, E Yamaguchi, K Furuya, N Hizawa, N Ohnuma, Y Kawakami, N Kuzumaki
Journal: Thorax (1993)

Granulocyte-macrophage colony stimulating factor (GM-CSF) has several proinflammatory effects, some of which potentially favour granuloma formation. Its mRNA expression by the inflammatory cells recovered from lungs of patients with pulmonary sarcoidosis has been previously reported. In this study an association between GM-CSF expression and manifestations of the disease was explored.GM-CSF mRNA was detected by reverse transcription polymerase chain reaction in the cells of bronchoalveolar lavage (BAL) fluid of 20 patients with pulmonary sarcoidosis.GM-CSF mRNA expression was positive in 15 of 20 patients with sarcoidosis. Fourteen of the 15 patients with positive mRNA expression had worsening or unchanged disease during the year preceding this study, on the basis of radiographic or physical findings, or both, whereas all five "negative" patients were judged to be improving. Similarly, serum levels of angiotensin converting enzyme, the proportion of lymphocytes in BAL fluid, and the CD4+/CD8+ ratio of lymphocytes in BAL fluid were significantly higher in the positive patients.There was an association between the presence of GM-CSF mRNA in the cells in BAL fluid and other indices of disease activity in sarcoidosis.
Medicopolitical Peace? — Challenge to Clinical Autonomy — Compulsory Seat Belts
Authors: John Lister
Journal: New England Journal of Medicine (1976)

The uneasy truce1 on the medicopolitical front in Britain has progressed to a rather fragile state of peace. The result of the consultants' ballot on their attitude to the government's modified proposals for phasing out private practice from the National Health Service (NHS) was indeterminate. First of all, there was a low poll,2 with only 7039 (53 per cent of those eligible to vote) returning their papers; 5165 objected to the proposed elimination of private practice from NHS hospitals, and 5995 objected to the government's stringent licensing proposals for the private sector outside the NHS. On the other hand, 4438 . . .
Ebola, Team Communication, and Shame: But Shame on Whom?
Authors: Sarah E. Shannon
Journal: The American Journal of Bioethics (2015)

Examined as an isolated situation, and through the lens of a rare and feared disease, Mr. Duncan's case seems ripe for second-guessing the physicians and nurses who cared for him. But viewed from the perspective of what we know about errors and team communication, his case is all too common. Nearly 440,000 patient deaths in the U.S. each year may be attributable to medical errors. Breakdowns in communication among health care teams contribute in the majority of these errors. The culture of health care does not seem to foster functional, effective communication between and among professionals. Why? And more importantly, why do we not do something about it?
BACTERIOLOGY OF THE BLOOD AND JOINTS IN RHEUMATIC FEVER
Authors: Russell L. Cecil, Edith E. Nicholls, Wendell J. Stainsby
Journal: The Journal of Experimental Medicine (1929)

1. During the Spring of 1928, 29 patients with acute rheumatic fever were subjected to blood cultures, of whom 9, or 31 per cent, yielded a streptococcus. During the Spring of 1929, 31 patients with acute rheumatic fever were studied by blood cultures, of whom 26, or 83.9 per cent, yielded a streptococcus. The higher percentage of positive cultures in the 1929 series appears to have been due to improved cultural methods. 2. Of the 35 strains of streptococci recovered from blood cultures, 33 have been classified as alpha streptococci (Str. viridans); one as a beta streptococcus (Str. hemolyticus); and one a gamma streptococcus (Str. anhemolyticus). Some of the viridans strains produced very little green on blood media. 3. Agglutination and absorption tests indicate that the strains of streptococcus viridans recovered from the blood of patients with rheumatic fever show a tendency to fall into specific biological groups. 4. In 7 patients with rheumatic fever who were subjected to cultures from affected joints, 5, or 71.4 per cent, yielded a streptococcus viridans. In 3 patients in whom green streptococci were recovered from both the blood and joint, agglutination and absorption tests proved the identity of the strains isolated from the two sources. 5. These findings corroborate those of previous investigators and make it difficult to escape the conclusion that rheumatic fever is a streptococcal infection usually of the alpha or viridans type. 6. The pathogenesis of rheumatic fever in respect to the joint lesions appears to be analogous to that of infectious arthritis and gonococcal arthritis. Bacterial allergy probably influences the clinical picture in all three conditions, but in each instance the joint manifestations are primarily dependent upon localization of bacteria in the joint, with subsequent infection.
Perplexities of a Periodic Entity
Authors: Hobart A. Reimann
Journal: JAMA (1964)

IN DEALING with a newly established entity before all the facts are at hand, different observers are impressed by different aspects of it, depending often upon personal interest, disregard of published views in some of the 125 pertinent publications, and thoroughness of investigation. For these reasons, much misconception and fallacy pertain to periodic peritonitis. Particularly confusing are the 15 names applied to it: A paroxysmal syndrome Armenian Disease Benign paroxysmal peritonitis Periodic abdominalgia Periodic peritonitis La maladie périodique La maladie dite périodique La maladie de Siegal-Cattan-Mamou La maladie périodique de Reimann Periodic fever Epanalepsie Mediterranéene Familian Mediterranean fever (FMF) Recurrent polyserositis Familial recurring polyserositis Familial paroxysmal polyserositis (FPP) Least desirable are the eponyms and the vivid euphonious names "Epanalepsie Mediterranéene" and "Familial Mediterranean fever" that are geographically restrictive and clinically uninformative. The disorder is worldwide and is not restricted to Armenians, Jews, and Arabs. The noun polyserositis, favored by many,
"THE VENEREAL DISEASES"
Authors: E. H. Hume
Journal: JAMA (1918)

<h3>To the Editor:</h3> —May I tell you how much inspiration has come to us through the series of articles published inThe Journalrecently on the treatment of venereal diseases? Among our students there has grown a strong conviction that the Chinese public needs education to prepare it for the crop of modern trained physicians now being educated. The students have translated several of the articles referred to, and I write on their behalf to tell you that we propose to use the translated material in the local press, making due acknowledgment toThe Journal.
German medical editors' uphill struggle
Authors: K. Kimbel
Journal: BMJ (1998)

At last year's meeting of the World Association of Medical Editors in Prague the major Anglo-Saxon medical journals presented themselves as being independent from outside pressures. Their main aim was to improve quality and the reliability of published papers.

During the discussions there were only hints that continental medical journals have more problems. But many of them struggle to retain editorial independence, and some used the meeting of the German society for internal medicine to voice their complaints. A recently published protocol by the society emphasises the importance of medical journals for science and education and sets out the peculiar position in which many continental medical journals find themselves.

Most of …