Intraperitoneal Erythromycin for Gastroparesis
Authors: Nand K. Wadhwa, Harold Atkins, Thelma Cabralda
Journal: Annals of Internal Medicine (1991)

Letters15 May 1991Intraperitoneal Erythromycin for GastroparesisNand K. Wadhwa, MD, Harold Atkins, MD, Thelma Cabralda, RNNand K. Wadhwa, MDSearch for more papers by this author, Harold Atkins, MDSearch for more papers by this author, Thelma Cabralda, RNSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-10-912_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Erythromycin appears to be a gastric prokinetic agent, which probably binds to motilin receptors and acts as a motilin agonist (1, 2). Erythromycin has recently been reported to improve gastric emptying in patients with gastroparesis associated with diabetes mellitus and progressive systemic sclerosis (3, 4). We report the case of a diabetic patient on continuous ambulatory peritoneal dialysis in whom intraperitoneal administration of erythromycin was effective in relieving vomiting from gastroparesis.A 41-year-old woman developed end-stage renal disease secondary to diabetic nephropathy and had been on continuous ambulatory peritoneal dialysis since July 1988. She has had insulin-dependent...References1. TomomasaKuroumeAraiWakabayashiItoh TTHKZ. Erythromycin induces migrating motor complex in human gastrointestinal tract. Dig Dis Sei. 1986;31:157-61. CrossrefMedlineGoogle Scholar2. KondoToriiItohOmura YKZS. Erythromycin and its derivatives with motilin-like biological activities inhibit the specific binding of 125-I-motilin to duodenal muscle. Biochem Biophys Res Commun. 1988;150:877-82. CrossrefMedlineGoogle Scholar3. JanssensPeetersVantrappen JTG. Improvement of gastric emptying in diabetic gastroparesis by erythromycin. N Engl J Med. 1990;322:1028-31. CrossrefMedlineGoogle Scholar4. DullRaufmanZakiaStrashunStraus JJMAE. Successful treatment of gastroparesis with erythromycin in a patient with progressive systemic sclerosis. Am J Med. 1990;89:528-30. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: State University of New York Health Sciences Center Stony Brook, NY 11794-8152 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGastrointestinal disorders and renal failure: exploring the connectionProtein and energy nutrition among adult patients treated with chronic peritoneal dialysisCisapride and erythromycin prokinetic effects in gastroparesis due to type 1 (insulin-dependent) diabetes mellitusTHERAPEUTIC STRATEGIES FOR MOTILITY DISORDERSStability of Drug Additives to Peritoneal DialysateStability of Erythromycin Lactobionate in Peritoneal Dialysate SolutionsErythromycin and other macrolides as prokinetic agentsGastroparesis: An Important Cause of Hospitalization in Continuous Ambulatory Peritoneal Dialysis Patients and the Role of ErythromycinIntraperitoneal Erythromycin for Diabetic Gastroparesis in Capo 15 May 1991Volume 114, Issue 10Page: 912-912KeywordsDiabetes mellitusErythromycinGastroparesisInsulinPeritoneal dialysisRenal failureSclerodermaVomiting Issue Published: 15 May 1991 PDF downloadLoading ...