Increased Helper/Suppressor T-Lymphocyte Ratio in the Cerebrospinal Fluid of a Patient with Neurosarcoidosis
Authors: JOHN L. JUOZEVICIUS
Journal: Annals of Internal Medicine (1986)

Brief Reports1 June 1986Increased Helper/Suppressor T-Lymphocyte Ratio in the Cerebrospinal Fluid of a Patient with NeurosarcoidosisJOHN L. JUOZEVICIUS, M.D., RICHARD I. RYNES, M.D.JOHN L. JUOZEVICIUS, M.D., RICHARD I. RYNES, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-6-807 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSarcoidosis has been characterized by abnormal immunologicactivity at the site of active pulmonary disease. Analysis of T-lymphocyte populations has shown an increasedhelper/suppressor (T4/T8) ratio among lymphocytesobtained by bronchoalveolar lavage, and a concomitantdecrease in the T4/T8 ratio in the blood (1). Central nervous system sarcoidosis, a rare manifestation of the disease, has been associated with increased morbidityand mortality (2). We present evidence that during active central nervous system sarcoidosis, T lymphocytes in the central nervous system show abnormalities analogousto those in the lung.A 21-year-old white man with biopsy-proven sarcoidosis was hospitalized at Albany Medical Center Hospital in June 1985. Sarcoidosis...References1. HUNNINGHAKE G and CRYSTAL R. Pulmonary sarcoidosis: a disorder mediated by excess helper T-lymphocyte activity at sites of disease activity. N Engl J Med. 1981;305:429-34. CrossrefMedlineGoogle Scholar2. DELANEY P. Neurologic manifestations in sarcoidosis: review of the literature, with a report of 23 cases. Ann Intern Med. 1977;87:336-45. LinkGoogle Scholar3. HOFFMAN R, KUNG P, HANSEN W, and GOLDSTEIN G. Simple and rapid measurement of human T lymphocytes and their subclasses in peripheralblood. Proc Natl Acad Sci USA. 1980;77:4914-7. CrossrefMedlineGoogle Scholar4. BRINKMAN C, NILLESEN W, and HOMMES O. T-cell subpopulations in blood and cerebrospinal fluid of multiple sclerosis patients: effect of cyclophosphamide. Clin Immunol Immunopathol. 1983;29:341-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN L. JUOZEVICIUS, M.D.; RICHARD I. RYNES, M.D.Affiliations: Albany Medical College Albany, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeurosarcoidosis: Two case reports with multiple cranial nerve involvement and review of the literatureNeurosarcoidosisIsolated neurosarcoidosis presenting as headache and multiple brain and spinal cord lesions mimicking central nervous system metastasesNeurosarcoïdose : état des connaissancesNeurosarcoidosis: a clinical dilemmaEndocrine aspects of neurosarcoidosisNeurologic Manifestations of SarcoidosisDiagnosis and management of neurosarcoidosisSpinal cord sarcoidosis: A diagnostic dilemmaOrofacial granulomatosis and related conditionsCase 8-1998Sarcoidosis en-plaque. Report of a case and review of the literatureConnective-tissue disease/muscle diseaseSarcoidosis and the Nervous SystemLight Microscopic Cytology of Cerebrospinal FluidFlow cytometric quantitation of T cell phenotypes in cerebrospinal fluid and peripheral blood of homosexual men with and without antibodies to human immunodeficiency virus, type ICyclosporine therapy of central nervous system sarcoidosis 1 June 1986Volume 104, Issue 6Page: 807-808KeywordsBronchoalveolar lavageCentral nervous systemCerebrospinal fluidLungsLymphocytesMortalityPopulation statisticsPulmonary diseasesRheumatologySarcoidosis ePublished: 1 December 2008 Issue Published: 1 June 1986 PDF downloadLoading ...