Routine Immunohistology in Renal Diseases
Authors: K. LANGE
Journal: Annals of Internal Medicine (1966)

Article1 January 1966Routine Immunohistology in Renal DiseasesK. LANGE, M.D., F.A.C.P., G. TRESER, M.D., I. SAGEL, M.D., A. TY, M.D., E. WASSERMAN, M.D.K. LANGE, M.D., F.A.C.P.Search for more papers by this author, G. TRESER, M.D.Search for more papers by this author, I. SAGEL, M.D.Search for more papers by this author, A. TY, M.D.Search for more papers by this author, E. WASSERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-1-25 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1907 it was suggested (1) that certain renal diseases may be caused by an immune reaction involving the glomerulus. This hypothesis has recently received renewed support. In 1951 we demonstrated the presence of antibodies against human kidney tissue emulsion in a group of patients with chronic glomerulonephritis (2). Studies revealing a lowering of serum complement activity in patients with acute glomerulonephritis, systemic lupus erythematosus, and nephrosis (3-7) lend added support to the possibility that an immune mechanism may be responsible for these diseases. Using an immunofluorescent technique on autopsy material from patients with glomerulonephritis, Mellors and Ortega (8) have...References1. SCHICK B: Die Nachkrankheiten des Scharlach. Jb. Kinderheilk. 65: 132, 1907. Google Scholar2. LANGEGOLDWEINERSIMON KMMDV: Autoantibodies in human glomerulonephritis. J. Clin. Invest. 28: 50, 1949. CrossrefGoogle Scholar3. VEILBUCHHOLZ WHB: Der Komplementschwund im Blute. Klin. Wschr. 11: 2019, 1932. CrossrefGoogle Scholar4. KELLETT CE: Complement titre in acute nephritis. Lancet 2: 1262, 1936. CrossrefGoogle Scholar5. VAUGHANBAYLESFAVOUR JHTBCB: Complement in disseminated systemic-lupus-erythematosus. J. Lab. Clin. Med. 37: 698, 1951. MedlineGoogle Scholar6. LANGESLOBODYGRAIGOGUROBERMANLO-CASTO KLFGJF: Serum complement in acute glomerulonephritis and the nephrotic syndrome. Pediatrics 8: 814, 1951. MedlineGoogle Scholar7. LANGEWASSERMANSLOBODY KELB: The significance of serum complement levels for the diagnosis and prognosis of acute and subacute glomerulonephritis and lupus erythematosus disseminatus. Ann. Intern. Med. 53: 636, 1960. LinkGoogle Scholar8. MELLORSORTEGA RCLG: Analytical pathology III. New observations on pathogenesis of glomerulonephritis, lipid nephrosis, periarteritis nodosa and secondary amyloidosis in man. Amer. J. Path. 32: 455, 1956. MedlineGoogle Scholar9. FREEDMANPETERSKARK PJHRM: Localization of gamma globulin in the diseased kidney. Arch. Intern. Med. (Chicago) 105: 524, 1960. CrossrefMedlineGoogle Scholar10. BURKHOLDER PM: Complement fixation in diseased tissues. I. Fixation of guinea pig complement in sections of kidney from humans with membraneous glomerulonephritis and rats injected with anti-rat kidney serum. 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LANGEWACHSTEINWASSERMANALPTEKINSLOBODY KMEFLB: The congenital nephrotic syndrome, an immune reaction? Amer. J. Dis. Child. 105: 338, 1963. CrossrefMedlineGoogle Scholar23. SCHÄFERSCHÄFER HEA: Aspekte zur Immunpathogenese der malignen Hypertonie. Med. Welt 1144, 1965. MedlineGoogle Scholar24. SEEGALHSUFIASCHIANDRES BCKCEG: La tecnica degli anticorpi fluorescenti applicata allo studio della patogenesi della nefrite umana. Rass. Fisiopat. Clin. Ter. 31: 1, 1959. MedlineGoogle Scholar25. MARKOWITZLANGE ASCF: Streptococcal related glomerulonephritis. I. Isolation immunochemistry and comparative chemistry of soluble fractions from type 12 nephritogenic streptococci and human glomeruli. J. Immun. 92: 565, 1964. MedlineGoogle Scholar26. LACHMANMÜLLER-EBERHARDKUNKELPARONETTO PJHJHGF: The localization of in vivo bound complement in tissue sections. J. Exp. Med. 115: 63, 1962. CrossrefMedlineGoogle Scholar27. GRISHMANPORUSH EJ: Electron microscopic studies of "minimal" lupus nephritis. Fed. Proc. 23: 446, 1964. Google Scholar28. DIXONFELDMANVAZQUEZ FJJDJJ: Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J. Exp. Med. 113: 899, 1961. CrossrefMedlineGoogle Scholar29. WESTNORTHWAYDAVIS CDJDNC: Serum levels of β1e globulin, a complement component in the nephritides, lipoid nephrosis and other conditions. J. Clin. Invest. 43: 1507, 1964. CrossrefMedlineGoogle Scholar30. DAMMINMERRILL JGJP: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: K. LANGE, M.D., F.A.C.P.; G. TRESER, M.D.; I. SAGEL, M.D.; A. TY, M.D.; E. WASSERMAN, M.D.Affiliations: New York, New YorkFrom the Renal Service and Laboratory, Departments of Medicine and Pediatrics, New York Medical College, New York, N. Y.This study was supported by grant A-302 (C7-12) from the Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md., and grants from the Kidney Disease Foundation of New York.Portions of this study were presented before the Annual Meeting of the American College of Physicians, April 9, 1964, Atlantic City, N. J., and the Annual Meeting of the Association of American Physicians, May 4, 1965, Atlantic City, N. J.Requests for reprints should be addressed to Kurt Lange, M.D., New York Medical College, 1 East 105th St., New York, N. Y. 10029. 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SHEARN, M.D., F.A.C.P.Vascular reactivity in essential and renal hypertension in man 1 January 1966Volume 64, Issue 1 Page: 25-40 Keywords Child health Glomerulonephritis Immune serum Kidneys Lupus erythematosus Metabolic disorders Pediatrics Renal diseases Research laboratories Systemic lupus erythematosus ePublished: 1 December 2008 Issue Published: 1 January 1966 PDF downloadLoading ...