tbuckley/cabot-search huggingface dataset:
Primary, Secondary, and Tertiary Prevention Program for Diabetes in Pregnancy
Authors: Roger S Mazze, Oded Langer
Journal: Diabetes Care (1988)

Over the past 2 yr the effectiveness of a program in primary, secondary, and tertiary prevention of diabetes in pregnancy was studied. The purpose of the program was to determine the degree to which preventive medicine in terms of early screening and diagnosis, rapid initiation of treatment, and close follow-up surveillance could reduce the morbidity and mortality associated with pregestational and gestational diabetes. The study compared the program in prevention with previous programs, and its results were measured against national criteria established by the Centers for Disease Control. A significant increase in early identification of gestational diabetes and a decrease in fetal and maternal complications were detected.
CHARACTERISTICS AND OUTCOMES OF PATIENTS UNDERGOING PERCUTANEOUS INTERVENTION FOR PERI-OPERATIVE MYOCARDIAL INFARCTION AFTER NON-CARDIAC SURGERY AT A HIGH VOLUME TERTIARY CARE CENTER
Authors: Akhil Parashar, Shikhar Agarwal, Nadeen Faza, Aatish Garg, Kanhaiya Poddar, E. Murat Tuzcu, Samir Kapadia
Journal: Journal of the American College of Cardiology (2014)
Local expression and systemic release of stem cell factor in systemic sclerosis with diffuse hyperpigmentation
Authors: T. Yamamoto, Y. Sawada, I. Katayama, K. Nishioka
Journal: British Journal of Dermatology (2001)

Sir, Systemic sclerosis (SSc), a connective tissue disease characterized by tissue fibrosis with excessive collagen deposition in the dermis or various internal organs, is of unknown pathogenesis. Histological examination reveals perivascular inflammatory infiltrates including macrophages, T lymphocytes or mast cells, in the early phase of scleroderma skin.1 We have observed that scleroderma patients often present with diffuse pigmentation as the disease progresses, associated with itching. The mechanism of the increased pigmentation and itching has not been elucidated. Recent investigation has shown that there is no evidence of adrenal deficiency in scleroderma patients.2 An increased number of mast cells is present in lesional skin of patients with oedematous phase scleroderma.3,4 Mast cells release a number of cytokines involved in the promotion of dermal sclerosis. We have recently observed that stem cell factor (SCF), a growth factor for mast cells, is strongly expressed on various types of cells including fibroblasts, endothelial cells, keratinocytes and mast cells in lesional skin of SSc.5 Recently, SCF expression in SSc has also been reported to be enhanced in the oedematous phase, whereas serum SCF level is elevated in the sclerotic phase.6 SCF also stimulates melanin production by melanocytes.7 We therefore assessed the serum level of SCF at several time points in a typical case of SSc showing diffuse hyperpigmentation in parallel with the disease progression.
A life at stake
Authors: T. Dalrymple
Journal: BMJ (2009)

Not many doctors, I think, have been burnt at the stake, though I am sure we could all nominate some of our colleagues who deserve to be. Perhaps the General Medical Council will soon reintroduce the medieval tradition for those doctors who refuse to abjure their errors and heresies; if so, surely the television rights and admission fees to the events could help to keep the annual subscription fee constant for a year or two.

The most eminent doctor ever burnt at the stake was Michael Servetus (1509 or 1511-1553), who studied medicine in Paris and managed the feat, difficult at the time, of being condemned to death for heresy …
GW25-e2346 Inhibition of Thioredoxin by Thioredoxin-Interacting Protein Mediates the Impairment of Ischemia-Induced Angiogenesis in Diabetic Myocardium
Authors: Yin Tao, Shen Mingzhi, Yang Guodong, Yuan Lijun, Wang Haichang
Journal: Journal of the American College of Cardiology (2014)
MASSIVE SKIN GANGRENE COMPLICATING CHICKENPOX
Authors: T. M. Watson
Journal: JAMA (1934)

This case is reported because massive gangrene of the skin is an unusual complication of chickenpox. <h3>REPORT OF CASE</h3> H. C. Jr., a schoolboy, aged 6 years, had had a normal birth and infancy. He had never had any severe illness. There had been frequent colds before the tonsils and adenoids had been removed two years before. Since that time he had been perfectly well except for a mild case of measles four months previously. He was doing well in school. There was an epidemic of chickenpox in the schools at the time of the onset of illness. Five days before he entered the hospital a low grade fever developed and the boy complained of pains in the joints. Two days later vesicles characteristic of chickenpox appeared on the skin. There were few of them and all indications pointed to a mild attack. On the fourth day of the illness
Dipyridamole Tl-201 Myocardial Single Photon Emission Computed Tomography in the Functional Assessment of Anomalous Left Coronary Artery From the Pulmonary Artery
Authors: Meng-Ling Chen, Hung-Shun Lo, Ing-Ming Chao, Hung-Yi Su
Journal: Clinical Nuclear Medicine (2007)

Anomalous origin of the left coronary artery from the pulmonary artery is a rare congenital heart disease. Without surgical correction, most patients with this anomaly die during infancy from myocardial infarction and heart failure, with a mortality rate reported to be greater than 90% by 1 year of age. Some patients with significant collateral circulation from the right coronary artery may remain asymptomatic and survive into adulthood, but they usually develop progressive left ventricular dysfunction. The detection of myocardial ischemia in these patients is important to identify viable myocardium at risk for irreversible damage. We present 1 such case in which dipyridamole Tl-201 SPECT myocardial perfusion imaging played an important role in the decision-making process and was shown to be useful for the evaluation of the surgical result.
EFFICACY AND SAFETY OF DIFFERENT DOSING REGIMENS OF ALIROCUMAB (STARTING DOSES OF 75 MG EVERY TWO WEEKS AND 150 MG EVERY FOUR WEEKS) VERSUS PLACEBO IN PATIENTS WITH HYPERCHOLESTEROLEMIA NOT TREATED USING STATINS: THE ODYSSEY CHOICE II STUDY
Authors: Erik S.G. Stroes, John Guyton, Michel Farnier, Norman Lepor, Fernando Civeira, Daniel Gaudet, Gerald Watts, Garen Manvelian, Guillaume Lecorps, Marie Baccara-Dinet
Journal: Journal of the American College of Cardiology (2015)
THE INFLUENCE OF COLLOIDAL PROTECTION ON MILK
Authors: JEROME ALEXANDER
Journal: JAMA (1910)

With the aid of the ultramicroscope which brings into visibility particles whose size approximates the theoretical molecular dimensions, it has been demonstrated that colloidal solutions occupy a sphere midway between coarse mechanical suspensions and true crystalloidal solutions. The slight Brownian movement of small suspended particles at the limit of visibility in the ordinary microscope (about ¼ micron), is insufficient to keep them afloat, and they gradually settle out of solution; but as the subdivision of the particles proceeds, this motion gradually increases in speed and amplitude, until it becomes so violent that the particles remain permanently afloat and in solution. Ultramicroscopic particles (ultramicrons) as small as about 5 microns (the present limit of the ultramicroscopic visibility) describe an average free path of about ten times their own diameter in one-sixth to one-eighth of a second. From a practical standpoint, colloids may be divided into the<i>stable</i>or<i>reversible</i>colloids or
Sequential catecholamine changes during upright tilt: Possible hormonal mechanisms responsible for pathogenesis of neurocardiogenic syncope
Authors: Jasbir Sra, Mohammad Jazayeri, Vishnubhakta Murthy, Patrick Tchou, Yue-Hua Shen, Paul Troup, Boaz Avitall, Masood Akhtar
Journal: Journal of the American College of Cardiology (1991)
Liposomal amphotericin B (AmBisome) compared with amphotericin B ± FMLP induces significantly less in vitro neutrophil aggregation with granulocyte–colony-stimulating factor/dexamethasone–mobilized allogeneic donor neutrophils
Authors: Maria Luisa Sulis, Carmella Van de Ven, Theresa Henderson, Lauren Anderson, Mitchell S. Cairo
Journal: Blood (2002)
Amyotrophic Lateral Sclerosis-Associated SOD1 Mutant Proteins Bind and Aggregate with Bcl-2 in Spinal Cord Mitochondria
Authors: Piera Pasinelli, Mary Elizabeth Belford, Niall Lennon, Brian J Bacskai, Bradley T Hyman, Davide Trotti, Robert H Brown
Journal: Neuron (2004)
Transplantation of Liver Grafts from Living Donors into Adults — Too Much, Too Soon
Authors: D C Cronin, J M Millis, M Siegler
Journal: New England Journal of Medicine (2001)

Since 1995, many liver-transplantation programs in the United States,1,2 Europe,3 and Asia4,5 have performed adult-to-adult transplantation of liver grafts from living donors. Since 1997, more than 30 U.S. transplantation programs have performed more than 400 of these procedures. Although six of these programs have performed only 1 procedure each, one program has performed more than 100. Twenty-three centers are planning to start such programs.6,7 Liver transplantation in adults with the use of grafts from living donors may initially have been regarded as a technical extension of the procedure for transplanting liver grafts from living donors into children. . . .
Beneficial or adverse effects of hepatectomy vs. ethanol injection therapy in RBT-1 carcinoma of the rat liver
Authors: Yasuharu Ikeda, Takashi Matsumata, Hiroshi Hayashi, Akinobu Taketomi, Kazuharu Yamamoto, Keizo Sugimachi
Journal: Hepatology (1994)

ABSTRACT In an attempt to ascertain the possible beneficial or adverse effects of ethanol injection into a hepatic malignant tumor, we carried out a series of experiments using the RBT–1 carcinoma. Ten days after the inoculation of RBT–1 carcinoma into the rat livers, the animals were separated into four groups: group A received a sham operation, group B had ethanol injections directly into the hepatic tumor, group C underwent tumor removal and group D underwent tumor removal 20 min after ethanol injection. When a comparison was made with all groups, survival time was significantly longer in group B than in A (p&lt;0.01), group C than A (p&lt;0.01) and group C than B (p&lt;0.01). The incidence of vascular permeation of liver tumor cells into the hepatic vein was significantly higher in group D than C (p&lt;0.05). Twenty days after initial injection of RBT–1 tumor, 10 rats in each group were killed, and their lungs were assessed for evidence of metastatic spread of tumor. The number of metastatic nodules in the lungs was significantly increased in those rats that had undergone intrahepatic ethanol injection vs. those that had not (group B vs. A [p&lt;0.05] and group D vs. C [p&lt;0.05]). The number of metastatic nodules in the lungs differed significantly in those rats that had undergone hepatectomy vs. those that had not. These results are taken to mean that hepatectomy and ethanol injection into a tumor was an effective therapy. However, we believe ethanol injection into hepatic tumors may increase the risk of metastasis and should not, at present, be recommended in those patients who have operable liver cancer. (Hepatology 1994;20:166-169.)
Opportunistic infections in acquired immune deficiency syndrome result from synergistic defects of both the natural and adaptive components of cellular immunity.
Authors: F P Siegal, C Lopez, P A Fitzgerald, K Shah, P Baron, I Z Leiderman, D Imperato, S Landesman
Journal: Journal of Clinical Investigation (1986)

We evaluated the cellular immunity of 408 clinically stratified subjects at risk for acquired immune deficiency syndrome (AIDS), to define the role of interferon-alpha production deficits in the pathogenesis of opportunistic infections (OI). We followed 115 prospectively for up to 45 mo. Onset of OI was associated with, and predicted by, deficiency both of interferon-alpha generation in vitro, and of circulating Leu-3a+ cells. Interferon-alpha production is an index of the function of certain non-T, non-B, large granular lymphocytes (LGL) that are independent of T cell help. Leu-3a+ cell counts are a marker of T cell function. OI did not usually develop until both of these mutually independent immune functions were simultaneously critically depressed, leading to a synergistic interaction. These data suggest that the AIDS virus affects a subset of LGL, and that cytokine production by these cells is an important component of the host defense against intracellular pathogens that becomes crucial in the presence of severe T cell immunodeficiency.
Mechanism of histamine-induced excitation of the cat pylorus.
Authors: P Biancani, L K CiCalzi, R W McCallum
Journal: Journal of Clinical Investigation (1981)

Intravenous histamine causes high amplitude repetitive phasic contractions of the in vivo cat pylorus but has little effect on the antrum and duodenum. The genesis of this phasic response was studied using a pinned perfused catheter with openings at the pylorus, antrum, and duodenum. 2-Pyridylethylamine, an H1 agonist, produced phasic contractions similar to histamine whereas dimaprit, an H2 agonist, did not. Conversely, histamine-induced excitation is competitively antagonized by the H1 inhibitor diphenhydramine but not by the H2 inhibitor cimetidine. Thus histamine excitation is mediated through H1 receptor stimulation. Tetrodotoxin caused inhibition of the histamine response indicating that pyloric excitation is partly mediated through a neural pathway. To identify the nature of this pathway adrenergic and cholinergic blockers were used. Atropine, hexamethonium, and propranolol had no effect on the histamine response. Phentolamine and reserpine increased the magnitude of the histamine response. Conversely, phenylephrine blocked the histamine response. We conclude: histamine induces high phasic contractions in the pylorus; this effect is mediated through neural (nonadrenergic noncholinergic) and myogenic H1 receptors; alpha adrenergic stimulation inhibits the histamine response and alpha adrenergic blockade and catecholamine depletion increase it.
RHINOPLASTY WITH FINGER
Authors: CLARENCE A. McWILLIAMS
Journal: JAMA (1913)

ing a good blood-supply to the flap.The bleeding from the leech-bite continued for twenty-four hours after the worm had been removed.It is my belief that this expedient will idten save Haps which would otherwise be lost, from a lack of blood supply, for in this case immediately after the appli¬ cation of the leech the flap became warm and of good color and remained so.The molding and shaping of the flap into the nose as you see ¡I has required several minor operations.There is an opening for nasal breathing, the appearance of the patient is greatly improved and she is well satisfied with the result.Much to my surprise she has sensation in her nose and she says that this is rapidly becoming .<acute.
Gout and amyloidosis.
Authors: Y Levo, O Shalev, E Rosenmann, M Eliakim
Journal: Annals of the Rheumatic Diseases (1980)

Two patients with gout and amyloidosis are reported. In contrast with other forms of chronic arthritis gout is apparently not associated with an increased incidence of amyloidosis. The possible reasons for this exception are discussed.
Nonpayment for Performance? Medicare's New Reimbursement Rule
Authors: Meredith B. Rosenthal
Journal: New England Journal of Medicine (2007)

Interview with Meredith Rosenthal on Medicare's decision to stop reimbursing hospitals for some of the care made necessary by improper care. (07:14)Download To defuse physicians' and hospitals' opposition to the creation of Medicare back in 1965, the program's congressional architects selected payment mechanisms designed to preserve the status quo.1 But as Medicare has expanded and problems of affordability and quality of care have grown, such an approach has become untenable. Recently, the Centers for Medicare and Medicaid Services (CMS) announced its decision to cease paying hospitals for some of the care made necessary by "preventable complications" — conditions that result from medical errors or improper care and that can reasonably be expected to be averted. This rule, which implements a congressionally mandated . . .
Stop and Smell the Bedpans
Authors: Daniel B. Mendlovic
Journal: Annals of Internal Medicine (2007)

Ad Libitum6 November 2007Stop and Smell the BedpansDaniel B. Mendlovic, MDDaniel B. Mendlovic, MDFrom Beachwood, OH 44122.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-9-200711060-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail On Sunday, the new ICU opened. After months of construction, the first patients were transferred in. Clearly, it was a huge upgrade. It was roomy, bright, and technologically advanced—all seemed thrilled with the new building. As I walked out through the now abandoned old ICU, I stopped to look around the old place.What a pit! It was musty, dark in some spots, with an intolerable glare in others. The temperature was never right, the floor was stained beyond repair, and there was never enough room to sit. A day ago, the rooms were full, but now it was already ... Author, Article, and Disclosure InformationAffiliations: From Beachwood, OH 44122.Current Author Address: Daniel B. Mendlovic, MD, 3733 Park East Drive, #105, Beachwood, OH 44122. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 November 2007Volume 147, Issue 9Page: 676KeywordsArterial blood gasCoffeeIntensive care unitsMemorySmellTemperature ePublished: 6 November 2007 Issue Published: 6 November 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
An unusual presentation of opportunistic mucormycosis.
Authors: G Helenglass, J A Elliott, N P Lucie
Journal: BMJ (1981)

An unusual presentation of opportunistic mucormycosisWe describe a fatal case of mucormycosis which complicated the treatment of a patient with acute myeloblastic leukaemia.Obstruction of the superior vena cava was a misleading and unreported clinical manifestation of this infection. Case reportA 64-year-old man was admitted with a two-week history of malaise.Examination showed pallor and severe oral candidiasis but no lympha- denopathy or hepatosplenomegaly.Investigation showed haemoglobin concentration of 9 1 g/dl, platelets 75 x 109/1, white cell count 5 x 109/1 (neutrophils 3 %, lymphocytes 28 %, myeloblasts 69 %).Auer rods were demonstrated.Acute myeloblastic leukaemia was confirmed on marrow on 30 July 2023 by guest.
Re: Frans Debruyne, Arkadij A. Gres, Dmitrii L. Arustamov. Placebo-Controlled Dose-Ranging Phase 2 Study of Subcutaneously Administered LHRH Antagonist Cetrorelix in Patients with Symptomatic Benign Prostatic Hyperplasia. Eur Urol 2008;54:170–80
Authors: Tomasz Drewa, Piotr Chlosta
Journal: European Urology (2008)
Suscefull Treatment of Posherpetic Neuralgia with Transfer Factor
Authors: E. Cervantes-Trujano, A. Rodríguez-Flores, A. Portugués-Díaz, U. Pacheco-García, R. Ondarza-Aguilera, R. Cortés-Gómez, S. Estrada-Parra
Journal: Journal of Allergy and Clinical Immunology (2006)
Chimerism testing and detection of minimal residual disease after allogeneic hematopoietic transplantation using the bioView (Duet™) combined morphological and cytogenetical analysis
Authors: A Shimoni, A Nagler, C Kaplinsky, M Reichart, A Avigdor, I Hardan, M Yeshurun, M Daniely, Y Zilberstein, N Amariglio, F Brok-Simoni, G Rechavi, L Trakhtenbrot
Journal: Leukemia (2002)
Politicians must commit resources and not just words to NHS, says BMA chairman
Authors: G. Iacobucci
Journal: BMJ (2014)

Pledges of support and election manifesto promises from politicians must be backed up by meaningful action to safeguard the NHS in 2015, the chairman of the BMA has warned. In his New Year’s message to members, Mark Porter said that doctors and patients should expect to hear all politicians pledge their support for the NHS in the run up to the general election in May but added …
Your Child's Health: A Pediatric Guide for Parents
Authors: Edward W. Collins
Journal: JAMA (1988)

Once again we are presented with a guide for parents on child rearing, and, in this now intensely competitive market, authors need to create something unique to stand above the crowd. After reading through this 562-page handbook-sized work, I think Schmitt has indeed done this quite well by having some clear goals of what the book is to be used for and by whom, namely, parents. Parents are their children's first-line health care provider for emergencies and common problems, we are told by Morris Green in the foreword. Schmitt follows through by writing a text and organizing the book to deliver concise factual information about not only problem management but also healthy lifestyles and preventive measures. Building confidence in making decisions about your child, he advises, is part of your development as a parent. This book will be a helper in those health care decisions, no doubt. A little intimidating
Comparison of maximal gastric secretion in smokers and non-smokers with and without duodenal ulcer.
Authors: P F Whitfield, M Hobsley
Journal: Gut (1987)

Maximal gastric secretion was induced in 122 control subjects (without peptic ulcer) and 201 preoperative duodenal ulcer patients by intravenous histamine acid phosphate (130 nmol/kg/h), and measured as Vg (ml/h) and MAO (mmol/h). In both groups, men secreted more than women, and smokers secreted more than non-smokers. Significant correlations were found between maximal gastric secretion on the one hand, and height, age, and chronic smoking on the other. After standardisation for these factors, including standardisation to zero smoking, the subgroups of the controls no longer differed significantly, as was also the case for the duodenal ulcer patients. Thus, differences in height, age, and smoking habit were sufficient to account for the variation in maximal secretion between individuals in either the control or duodenal ulcer groups. Even after standardisation, however, the duodenal ulcer patients still secreted significantly more than the controls, and therefore, although chronic smoking has been shown to affect maximal gastric secretion, it does not appear to be the sole reason for hypersecretion in duodenal ulcer patients.
Ampicillin in Chronic Bronchitis
Authors: P. C. Elmes
Journal: BMJ (1965)

<h3>Background</h3> Subclinical acute ischaemic lesions have recently been described in spontaneous intracerebral haemorrhage (sICH). We hypothesised that they are related to MRI markers of small vessel disease [SVD] (hypertensive arteriopathy or cerebral amyloid angiopathy [CAA]) in a multicentre, cross-sectional study. <h3>Methods</h3> We studied consecutive patients with sICH from four stroke centres, and age-matched stroke referrals without sICH. Acute ischaemic lesions were assessed on MRI (&lt;3 months post-sICH) using diffusion-weighted imaging (DWI). White matter changes (WMC) and cerebral microbleeds (CMBs) were rated. We investigated associations between DWI lesions, clinical and radiological characteristics. <h3>Results</h3> We included 114 sICH patients (39 with probable CAA); and 47 controls. The prevalence of DWI lesions was 9/39 (23%) in probable CAA-related ICH vs 6/75 (8%) in the remaining patients with sICH (p=0.024); no DWI lesions were found in controls. DWI lesions were associated with WMC score (OR 1.14 per unit increase, p=0.024) and strictly lobar CMBs (OR 3.85, p=0.029). <h3>Conclusion</h3> Acute, subclinical ischaemic brain lesions are frequent after sICH, and three times more common in CAA-related ICH than in other ICH types. They are associated with WMC and CMBs, suggesting that they result from an occlusive small vessel arteriopathy. They contribute to the overall burden of vascular-related damage in ICH, and may be a useful surrogate marker of ongoing ischaemic injury from SVD.