tbuckley/cabot-search huggingface dataset:
Royal Porphyria? — Somerset Maugham — Television Guilt
Authors: John Lister
Journal: New England Journal of Medicine (1966)

FIVE times during his long reign George III was thought to have suffered from episodes of madness that caused considerable political and constitutional concern at the time.His first symptoms occurred in 1765, when he was twenty-six, and the first 4 attacks lasted for periods up to six months, but the last attack began in 1810 and he continued to have symptoms until his death in 1820 at the age of eighty-one.It seems that he recovered fairly completely from the first 4 attacks but it was the uncertainty whether he would do so that exercised his political and medical . . .
Robert Harold Champion
Authors: Richard J Pye, Stephen Roberts
Journal: BMJ (2005)

​ConsultantConsultant dermatologist Addenbrooke's Hospital, Cambridge, 1961-91 (b Kent 1929; q Cambridge/Middlesex Hospital Medical School 1953; MA, FRCP), died from acute leukaemia on 16 October 2004.




Figure 1




It was during a house job at Addenbrooke's that Bob met Arthur Rook, who inspired him to become a dermatologist. Following his senior registrar post at St Thomas's Hospital he returned to Addenbrooke's as a consultant in 1961. He co-edited later editions of Rook's Textbook of Dermatology, edited the British Journal of Dermatology, and cowrote a much cited monograph on urticaria. He became president of the British Association of Dermatologists in 1988. He was an avid collector of jade, postage stamps, and more recently revenue stamps and licences. In later years he learnt to play the flute. Predeceased by his two sons, he leaves a wife, Phyllis, and a daughter.
Modulation of HCV reinfection after orthotopic liver transplantation by fibroblast growth factor-2 and other non-interferon mediators
Authors: Nguyen Dinh Van, Christine S Falk, Lisa Sandmann, Florian W R Vondran, Fabian Helfritz, Heiner Wedemeyer, Michael P Manns, Sandra Ciesek, Thomas von Hahn
Journal: Gut (2015)

<h3>Objective</h3> In HCV infected individuals graft infection occurs shortly after orthotopic liver transplantation (OLT). We aimed to describe the composition of the inflammatory response at this time, how it affects the HCV replication cycle and identify novel proviral and antiviral factors. <h3>Design</h3> We used a Luminex assay to quantify 50 inflammatory mediators in sera before and shortly after OLT. In vitro grown HCV based on the JFH-1 isolate were used to characterise the effects of patient sera and individual mediators on HCV. <h3>Results</h3> Although the mediator composition is highly variable between individuals, sera drawn immediately post-OLT significantly enhance HCV infectivity compared with control sera from before OLT in about half of the cases. Among 27 non-interferon inflammatory mediators fibroblast growth factor (FGF)-2 stood out as it enhanced HCV RNA replication and release of infectious particles. The effect was concentration-dependent and detectable in dividing and non-dividing cells. Moreover, pharmacological inhibition of FGF-2 receptor signalling abrogated the enhancing effect of FGF-2 and inhibited HCV replication in the absence of serum FGF-2 suggesting that HCV replication is dependent on basal activation of the FGF-2 triggered signalling pathway. Finally, in individuals with chronic HCV infection with high viral load, serum FGF-2 was significantly higher compared with those with low viral load. <h3>Conclusions</h3> Although no single mediator may account for this effect, serum shortly post-OLT enhances HCV infection. FGF-2 is a novel endogenous driver of HCV replication and a potential therapeutic target.
Regression of Ocular Melanoma Metastatic to the Liver After Hepatic Arterial Chemoembolization With Cisplatin and Polyvinyl Sponge
Authors: Giora M. Mavligit, Chuslip Charnsangavej, C. Humberto Carrasco, Yehuda Z. Patt, Robert S. Benjamin, Sidney Wallace
Journal: JAMA (1988)

Thirty patients with ocular melanoma metastatic to the liver were treated by hepatic arterial chemoembolization using an admixture of cisplatin and polyvinyl sponge. Tumor regression was complete in one patient and partial (greater than 50%) in 13 patients. The total response rate was 46%. The median survival for the entire group was 11 months (95% confidence interval, nine to 18 months). Treatment-related morbidity was short-lived and included primarily severe upper right quadrant abdominal pain, transient paralytic ileus, and nonicteric hepatitis. Hepatic arterial chemoembolization provided effective palliation, with good-quality survival among 46% of patients with ocular melanoma metastatic to the liver.
Paramyxovirus-Like Structures in Kidneys of Patients with Systemic Lupus Erythematosus.
Authors: H. B. Kelso
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Paramyxovirus-Like Structures in Kidneys of Patients with Systemic Lupus Erythematosus.H. B. Kelso, M.D., C.C. Tisher, M.D., J. C. Gunnells, M.D., F.A.C.P., R. R. Robinson, M.D., F.A.C.P., P. M. Burkholder, M.D.H. B. Kelso, M.D.Search for more papers by this author, C.C. Tisher, M.D.Search for more papers by this author, J. C. Gunnells, M.D., F.A.C.P.Search for more papers by this author, R. R. Robinson, M.D., F.A.C.P.Search for more papers by this author, P. M. Burkholder, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-831_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIntraendothelial paramyxovirus-like structures have been reported in renal glomeruli of patients with systemic lupus erythematosus (SLE). Their specificity, etiologic significance, and possible contribution to the pathogenesis of lupus nephritis and SLE remain unclear. The renal biopsy experience at Duke University was reviewed to determine the clinicopathologic correlates and incidence of these structures in proved SLE. Renal biopsies of 26 patients with proved SLE (group I) were studied by light, immunofluorescent, and electron microscopy and compared with 211 biopsies from patients with a variety of primary and secondary diseases (group II). In Group I 23 out of 26 biopsies exhibited intraendothelial... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Durham, N.C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 831-831KeywordsBiopsyElectron microscopyKidneysLupus erythematosusLupus nephritisPathogenesisRenal diseasesSpecificity Issue Published: 1 May 1971 PDF DownloadLoading ...
Case 9-1962
Authors: Guy W. Leadbetter
Journal: New England Journal of Medicine (1962)

Presentation of Case First admission. A forty-eight-year-old woman was admitted to the hospital because of pain in the right buttock and thigh.Nodules began to appear in the skin when the patient was in the late teens and continued to develop over the ensuing years. Twenty years before admission a painless swelling appeared in the right posterior aspect of the thigh. Four years before entry that area became painful, and a tumor that was intimately associated with the sciatic nerve was excised at another hospital; pathological examination revealed a neurofibroma. Progressive pain and swelling recurred in the right buttock and . . .
Selective T cell receptor decrease in peripheral blood T lymphocytes of patients with polymyalgia rheumatica and giant cell arteritis
Authors: M Lopez-Hoyos
Journal: Annals of the Rheumatic Diseases (2003)

<b>Objectives:</b> To investigate the phenotype and T cell receptor (TCR) use in peripheral blood T cells in patients with polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). <b>Methods:</b> Circulating T lymphocyte phenotype and TCR repertoire were studied by flow cytometry using specific monoclonal antibodies in 23 healthy controls and 37 patients with PMR/GCA. <b>Results:</b> Patients with active PMR/GCA showed an inverse relation between naive and memory CD4+ T cells and unchanged expression of activation surface markers compared with controls. CD4+ TCR BV expansions were seen in 12 (52%) controls and in 8 (22%) patients with active disease (p = 0.03). Within the CD8+ subset, the frequency of expansions was similar between groups. Most T cell expansions remained stable over time. Seventeen of the 23 patients with active PMR/GCA disclosed a simultaneous CD4+ and CD8+ T cell depletion for at least one particular BV family with a clear predominance of BV5S2/S3. <b>Conclusions:</b> The phenotype of circulating T cells in patients with PMR/GCA is similar to that found in aged healthy subjects, except for the surface markers of naive and memory cells and a striking non-activated phenotype. Specific BV expansions in CD4+ and CD8+ T cells, which remain stable over time, are frequent in aged subjects, including patients with PMR/GCA. TCR BV changes in patients with active disease seem to be also age related, except for the significant decrease in certain BV families in both CD4+ and CD8+ T cell subsets, which may favour the participation of a superantigen stimulation in PMR/GCA.
Single hepatocellular carcinomas larger than 4 CM mainly occur in the right liver lobe in the absence of cirrhosis or viral disease
Authors: Michele Zuckermann, Francesco Cetta, Maria Teresa Del Vecchio, Loreta Pergola, Monica Piccini, Roberto Dell'Avanzato, Antonio De Martino, Giorgio Ercolani, Alighieri Mazziotti
Journal: Journal of Hepatology (2002)
Thymoproteasome Shapes Immunocompetent Repertoire of CD8+ T Cells
Authors: Takeshi Nitta, Shigeo Murata, Katsuhiro Sasaki, Hideki Fujii, Adiratna Mat Ripen, Naozumi Ishimaru, Shigeo Koyasu, Keiji Tanaka, Yousuke Takahama
Journal: Immunity (2010)
THE DRAINAGE CANAL OF THE VALLEY OF MEXICO.
Authors: HENRY O. MARCY
Journal: JAMA (1903)

For many reasons our southern republic has an increased interest to the people of the United States. The marvelous development which has taken place in Mexico during the last two decades reflects, in a large degree, the progress of civilization on this western continent. Under the extraordinary wisdom, energy and foresight of President Diaz, the former chaotic governmental rule has disappeared, to be replaced by a wise and good government, making life and property interests as safe as in the United States. A network of railways is interlacing the republic in every direction. These now measure over seven thousand miles, built in great part by foreign, chiefly American, capital. Every department of industry is being developed with an hitherto unknown energy, and the enterprising American appears as the promoter or owner in all the more prominent sections of the country. This is especially noteworthy in the agricultural and mining interests.
Male sex hormone status in dermatitis herpetiformis
Authors: D.J. GAWKRODGER, V.M. SWEETING, C.R.W. EDWARDS, R.StC. BARNETSON
Journal: British Journal of Dermatology (1985)

In twenty-eight men with dermatitis herpetiformis (DH) the mean serum testosterone levels were within normal limits, but high levels were found in three patients with partial villous atrophy and two who had normal jejunal biopsies. The introduction of a gluten-free diet in patients with villous atrophy produced a statistically significant fall in the testosterone level in those able to discontinue their drug treatment but not in those noticing no change or only a reduction in drug requirements. The serum levels of luteinizing hormone or follicle-stimulating hormone were increased in nine patients; only one of these had a raised testosterone level and six were over 60 years of age. Four out of twenty married males with DH had no children, a figure higher than expected. Three of these men had elevated gonadotrophin levels although none had an increased serum testosterone. Thus, raised levels of testosterone and gonadotrophin were found in only a minority of men with DH, in contrast to the more marked changes previously reported in males with coeliac disease.
Loss of The Retinoblastoma Tumor-Suppressor Gene in Parathyroid Carcinoma
Authors: Vincent L. Cryns, Ann Thor, Hong-Ji Xu, Shi-Xue Hu, Margaret E. Wierman, Austin L. Vickery, William F. Benedict, Andrew Arnold
Journal: New England Journal of Medicine (1994)

The origin and molecular pathogenesis of parathyroid carcinoma are unknown. This life-threatening cause of primary hyperparathyroidism cannot be reliably distinguished from its benign counterpart on the basis of histopathological features alone. Because the PRAD1, or cyclin D1, gene, a cell-cycle regulator, has been implicated in a subgroup of benign parathyroid tumors, we examined the possibility that another cell-cycle regulator with possible functional links to PRAD1, the retinoblastoma tumor-suppressor gene (RB), might be involved in the molecular pathogenesis of parathyroid carcinoma.
Guidelines for management of asthma
Authors: M A Ganderton
Journal: BMJ (1990)

tract who develop acute papillary necrosis.Such patients will not present with renal failure if the contralateral kidney functions normally, and under these circumstances the diagnosis of an obstructed pyonephrosis can easily be delayed, with potentially serious consequences for renal function.If acute obstruction is suspected in the presence of infection a negative ultrasonogram is of no clinical value (and, as Dr Webb implies, a dilated collecting system will require further evaluation by other means).Such patients deserve urography, and if this shows a "non-functioning" kidney antegrade pyelography should be carried out, which can be followed by percutaneous drainage if obstruction is present.
Serum IgG autoantibodies directed against the alpha chain of Fc epsilon RI: a selective marker and pathogenetic factor for a distinct subset of chronic urticaria patients?
Authors: E Fiebiger, D Maurer, H Holub, B Reininger, G Hartmann, M Woisetschläger, J P Kinet, G Stingl
Journal: Journal of Clinical Investigation (1995)

While it is well established that acute allergic urticaria is caused by degranulation of skin mast cells occurring after allergen/IgE-dependent cross-linking of high affinity IgE receptors (FcepsilonRI), the pathophysiologic mechanisms operative in chronic urticaria (CU) are less well understood. Some evidence points to the existence of histamine-releasing activity in the serum of CU patients which possibly acts via triggering of FcepsilonRI. In this study, we aimed to better characterize this anti-FcepsilonRIalpha reactivity of CU patients using affinity-purified, IgE-depleted IgG fractions of such individuals (CU-IgG). Using immobilized, recombinant soluble FcepsilonRIalpha as a a reaction target for Western blot studies, we found that 12/32 (37%) CU-IgG serum samples exhibited IgG autoreactivity against FcepsilonRI- alpha. These findings were confirmed by experiments demonstrating that immunoblot-reactive, but not immunoblot-nonreactive, CU-IgG preparations precipitated the FcepsilonRIalpha from FcepsilonRI- alphagamma-transfected cells. No anti-FcepsilonRIalpha reactivity was observed in IgG fractions from atopic dermatitis (AD) patients (0/15) or healthy control individuals (CO:0/15). As opposed to the selective occurrence of IgG anti-Fc epsilon RI alpha autoantibodies in CU patients, IgG anti-IgE antibodies were detected in all groups investigated (CU: 69%; AD: 73%; CO: 26%). While both types of autoantibodies can exhibit histamine-releasing properties, not all of the autoantibodies proved to be functional in vitro. Our results indicate that the occurrence of IgG anti-FcepsilonRIalpha reactivity defines an autoimmune-mediated subentity of CU and provide a basis for the development of new diagnostic procedures and, perhaps, therapeutic strategies for this disease.
Précis of O'Keefe &amp; Nadel's<i>The hippocampus as a cognitive map</i>
Authors: John O'Keefe, Lynn Nadel
Journal: Behavioral and Brain Sciences (1979)

Abstract Theories of spatial cognition are derived from many sources. Psychologists are concerned with determining the features of the mind which, in combination with external inputs, produce our spatialized experience. A review of philosophical and other approaches has convinced us that the brain must come equipped to impose a three-dimensional Euclidean framework on experience – our analysis suggests that object re-identification may require such a framework. We identify this absolute, nonegocentric, spatial framework with a specific neural system centered in the hippocampus. A consideration of the kinds of behaviours in which such a spatial mapping system would be important is followed by an analysis of the anatomy and physiology of this system, with special emphasis on the place-coded neurons recorded in the hippocampus of freely moving rats. A tentative physiological model for the hippocampal cognitive map is proposed. A review of lesion studies, in tasks as diverse as discrimination learning, avoidance, and extinction, shows that the cognitive map notion can adequately explain much of the data. The model is extended to humans by the assumption that spatial maps are built in one hemisphere, semantic maps in the other. The latter provide a semantic deep structure within which discourse comprehension and production can be achieved. Evidence from the study of amnesic patients, briefly reviewed, is consistent with this extension.
Diabetes Research Plan Presented to Congress
Authors: Charles Marwick
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expectoration of Shell Fragment after 29 years
Authors: N. Oswald
Journal: BMJ (1947)

DRIP BR^^lSH, 455 symptoms associated with the tongue lesion.Mutch (1947) found it also when using inhalations of a nebulized aqueous solution of penicillin.The pastille base has been blamed for the condition.In my cases, however, the only vehicle used was saline, and still the black tongue developed.I tried the method on myself and developed a typical tongue after running the drip for three successive nights (a total of 50,000 units of penicillin), but failed to produce any such change with saline alone.This suggests that penicillin itself, or some contained impurity, is responsible and may act by causing an alteration to the normal flora of the mouth.I think this method of applying penicillin has a place in the treatment of faucial infections caused by Vincent's organisnms and in certain other severe throat infections, including the first day or two of severe faucial diphtheria.Also, it may well be applicable to surgical conditions of the throat.
"THE RESISTANCE OF MALARIA TO QUININ"
Authors: John W. Shuman
Journal: JAMA (1924)

<h3>To the Editor:</h3> —I can heartily endorse Fletcher's assertion with reference to the value of quinin in malaria, reviewed in the editorial on the resistance of malaria to quinin (The Journal, April 5). In 1922-1923 while I was director of internal medicine in the American University of Bierut, Syria, eighty-nine hospitalized patients were treated with quinin for malaria. The types recognized by the parasite in the blood were tertian, sixty-three; quotidian, nineteen, and quartian, seven. All were arrested; by arrest is meant a cessation of chills and fever and a disappearance of the plasmodium from the peripheral blood. The quinin was administered, to the average patient, by mouth, 15 grains (1 gm.) in the early morning on an "empty stomach"; and 15 grains at 10 p. m. Usually three or four days was a sufficient length of time to secure an arrest. The earlier the infection was recognized and proper
Do psyhiatric out-patients take their drugs?
Authors: D. R. Willcox, R. Gillan, E. H. Hare
Journal: BMJ (1965)

It is common clinical experience that there are patients who do not take the drugs prescribed for them. Less is known of the frequency with which this occurs, but a number of studies have indicated that the failure rate may be surprisingly high?up to 50% (Benstead and Theobald, 1952 ; Haler, 1952 ; Mohler et al, 1955 ; Simpson, 1956 ; Dixon et al., 1957 ; Luntz and Austin, 1960). The present study was undertaken to determine the propor tion of psychiatric out-patients who do not take their drugs, and to examine some factors possibly associated with this.
Pharmacotherapy in the Management of Obesity-Reply
Authors: Susan Yanovski
Journal: JAMA (1997)

<h3>In Reply.</h3> —We appreciate the reminders from Dr Tiedt that long-term changes in diet and exercise, whether or not assisted by medication, are required for long-term maintenance of weight loss. We wish to reiterate that anorexiant medications should not be used in isolation, but only in conjunction with programs designed to enable patients to make and sustain those changes. Overall, the effects of currently available anorexiant medications are modest; however, many patients do sustain sufficient weight loss to improve obesity-related risk factors. While the secular trends toward decreased physical activity and increased dietary intake noted by Tiedt undoubtedly have contributed to the alarming increase in obesity in the United States, there is mounting evidence that genetic and metabolic factors play an important role in predisposing certain individuals to the development of obesity.<sup>1,2</sup>In addition, physicians must not ignore the enormous public health and personal burdens obesity places on society and individuals.
Technical Aid for Facilitating Emergency Endoscopy
Authors: J. Sontheimer, R. Salm, M. Cegla, D. Reichenbacher
Journal: Endoscopy (1989)

Emergency endoscopy is usually complicated by unfavorable examination conditions. The irrigating capability of the instrument is inadequate. The use of an easy-to-operate volume- and pressure-driven irrigation pump has proved very efficient and safe in the hands of an experienced endoscopist, and helps establish the correct diagnosis or provide proper treatment.
EARLY TRANSMITRAL FLOW VELOCITY/EARLY DIASTOLIC VELOCITY OF MITRAL ANNULUS RATIO IS BETTER THAN MITRAL INFLOW PATTERN FOR EVALUATION OF DIASTOLIC DYSFUNCTION
Authors: Jin Bae Lee, Kee SIk Kim, Byoung Kyu Kim, Myung Jun Seong, Young Soo Lee, Jae Kean Ryu, Ji Yong Choi, Sung Gug Chang, So Yeon Kim
Journal: Journal of the American College of Cardiology (2011)