tbuckley/cabot-search huggingface dataset:
Exercise capacity and incidence of myocardial perfusion defects after Kawasaki disease in children and adolescents
Authors: Stephen M. Paridon, Frank M. Galioto, Julie A. Vincent, Teresa L. Tomassoni, Nancy M. Sullivan, J. Timothy Bricker
Journal: Journal of the American College of Cardiology (1995)

This study evaluated exercise performance and myocardial perfusion during exercise in patients with Kawasaki disease who had a broad spectrum of residual coronary abnormalities.Reports of exercise performance after Kawasaki disease have generally included a small number of patients evaluated by various protocols, frequently with incomplete data. Myocardial perfusion studies have usually been limited to those using pharmacologically induced coronary vasodilation. Therefore, to our knowledge there has not been a large study directly correlating exercise performance, electrocardiographic (ECG) changes and myocardial perfusion imaging.Forty-six patients were classified into three groups on the basis of coronary artery status: group 1 (n = 27) had no objective evidence of coronary artery lesions; group 2 (n = 11) had resolved aneurysms; group 3 (n = 8) had persistent coronary aneurysms. All patients underwent exercise testing with monitoring of ECG changes and oxygen consumption. Single-photon emission computed tomographic imaging was performed at rest and during peak exercise using technetium-99m sestamibi.Maximal oxygen consumption was within normal limits and was similar for all three groups. Five patients had mild ST segment changes at peak exercise. Two of these patients had stress-induced perfusion defects. Myocardial perfusion defects were present in 37% of patients in group 1, 63% in group 2 and 100% in group 3. Perfusion defects corresponded to the coronary artery lesion site in all but three patients.Maximal oxygen consumption is normal after Kawasaki disease regardless of coronary artery status. Stress-induced perfusion defects are frequent even in the absence of coronary abnormalities and are common in the absence of ST segment changes suggestive of ischemia.
Meningococcal pericarditis without meningitis.
Authors: D G Thompson, C T Pease, A J Howard
Journal: BMJ (1977)

Meningococcal pericarditis without meningitisThe number of reported cases of meningococcal pericarditis without clinical evidence of meningitis is very small.We report a further case additionally complicated by peritonitis, arthritis, and urethritis. Case reportThe patient was a 14-year-old Negro schoolboy.Five weeks before admis- sion he spontaneously developed painful swelling of his right knee, lasting five days before resolving completely.The night before admission he suffered
What Does a Hip Replacement Cost?
Authors: Andrew Steinmetz, Ezekiel J. Emanuel
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Identification of an Epigenetic Profile Classifier That Is Associated with Survival in Head and Neck Cancer
Authors: Graham M. Poage, Rondi A. Butler, E. Andrés Houseman, Michael D. McClean, Heather H. Nelson, Brock C. Christensen, Carmen J. Marsit, Karl T. Kelsey
Journal: Cancer Research (2012)

Panels of prognostic biomarkers selected using candidate approaches often do not validate in independent populations, so additional strategies are needed to identify reliable classifiers. In this study, we used an array-based approach to measure DNA methylation and applied a novel method for grouping CpG dinucleotides according to well-characterized genomic sequence features. A hypermethylation profile among 13 CpG loci, characterized by polycomb group target genes, mammalian interspersed repeats, and transcription factor-binding sites (PcG/MIR/TFBS), was associated with reduced survival (HR, 3.98; P = 0.001) in patients with head and neck squamous cell carcinoma. This association was driven by CpGs associated with the TAP1 and ALDH3A1 genes, findings that were validated in an independent patient group (HR, 2.86; P = 0.04). Together, the data not only elucidate new potential targets for therapeutic intervention in head and neck cancer but also may aid in the identification of poor prognosis patients who may require more aggressive treatment regimens.
A Survey of Immunization Levels After an Oral Poliovaccine Program in Cleveland
Authors: Martha L. Lepow, Robert E. Serfling, Ida L. Sherman, Frederick C. Robbins
Journal: JAMA (1964)

IN THE LATE spring and summer of 1962, an intensive program for distribution of Sabin oral poliovaccine was carried out in the Cleveland area. This program was modeled after the "Sabin-on-Sunday" (SOS) method of community immunization developed in Phoenix and Tucson, Arizona.<sup>1</sup>As the campaign progressed, it appeared that community-wide participation had been achieved as evidenced by the crowds of people who came to distribution centers in all socioeconomic areas. Efforts to achieve this goal of community-wide immunization have been stimulated by the occurrence in recent years of severe poliomyelitis epidemics with concentration of high attack rates in the lower socioeconomic areas of cities 2S and the concurrent observation of generally low levels of inactivated poliovaccine immunization levels in the areas with highest rates.<sup>5-8</sup>Although much work has been expended in campaigns to reduce this problem, results frequently have been less successful in reaching the target populations than was
Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment
Authors: Xuexian O Yang, Pornpimon Angkasekwinai, Jinfang Zhu, Juan Peng, Zhiduo Liu, Roza Nurieva, Xikui Liu, Yeonseok Chung, Seon Hee Chang, Bing Sun, Chen Dong
Journal: Nature Immunology (2009)
The Pathogenesis of Infectious Disease
Authors: Daniel L. Weiss
Journal: JAMA (1977)

One of a series of monographs for students of medicine, this little book is an exciting, though somewhat expensive, contribution to the explication of the infectious process. Unlike most volumes on infectious disease, there is no formal taxonomic microbiology or immunology presented in the usual sense. Rather, Dr Mims has chosen to crystallize his discussion by the broader presentation of the interactions between infecting agent and host, alluding to microbiological and immunologic characteristics only as they serve to explain pathogenesis. By taking this approach, the dynamics of infectious disease becomes the main focus, rather than the specific infections. For example, when dealing with phagocytosis, bacteria, viruses, fungi, and protozoa are considered together, their differences appearing only as the biological equations differ. This approach requires reasonable prior knowledge of medical microbiology and immunology but places such information in the stimulating context of the variations of the pathogenetic process. Dr Mims proceeds
Renal-Cell Carcinoma — Molecular Pathways and Therapies
Authors: James Brugarolas
Journal: New England Journal of Medicine (2007)

Renal-cell carcinoma is among the most resistant of tumors to therapy. Until 2005, only a single treatment, high-dose interleukin-2, had been approved by the Food and Drug Administration (FDA) for the treatment of this disease. The approval was based on durable complete responses in 5% of patients with metastatic disease,1 but high-dose therapy with interleukin-2 is quite toxic, and in most patients its benefit is unclear.In this issue of the Journal, Motzer et al.2 and Escudier et al.3 report on the results of phase 3 trials of two oral, small-molecule kinase inhibitors, sunitinib malate and sorafenib, respectively. Both drugs . . .
ON THE EXTENSION TREATMENT OF GUNSHOT FRACTURES
Authors: E. W. H. Groves
Journal: BMJ (1916)

_DCLJUtA Whien finger cases were dressed care was taken to vlove. the various joints passively before reapplying the dressing.Joints tend to get very stiff under overlying burns, and dangerously so if left unmoved for any length of time.The patient holds his \ L 1/ -w burnt hands and wrists in a position of flexion of the wrist with extension of the fingers.Any tendency to wrist-drop was countered by the application of a light splint (for example, poroplastic) to the palmar sur- face of the limb.Only tlie treatment that FIG.4.-The dressing complete.was actually employed in the series lhas been detailed.Por ordinary septic wounds, particularly where there is a cavity, I consider tllat eusol solution is deservedly popuilar; for septic burns, however, I prefer the lhot boracic fornentatioius.Lists of the cases treated in my wards are attached.I am indebted to Surgeon Glover for the plhotographs from wllich the drawings have been made.Burns uLp to the Third Degree.
KIR3DS1, KIR2DS1, and KIR2DS5 Protect Against the Development of Severe Recurrent Respiratory Papillomatosis (RRP) in HPV-6/11-Infected Patients
Authors: V.R. Bonagura, Z. Du, L. Luo, D. Gjertson, L.J. Hatam, J. DeVoti, D.W. Rosenthal, E. Reed, R. Rajalingam
Journal: Journal of Allergy and Clinical Immunology (2009)
Healing Our <i>Sicko</i> Health Care System
Authors: Jacob S. Hacker
Journal: New England Journal of Medicine (2007)

Interview with Jacob Hacker on Michael Moore’s movie Sicko and the outlook for reform in the U.S. health care system. (05:54)Download There is a scene in Sicko — Michael Moore's controversial new film about U.S. health care — that captures both the power and the limits of Moore's cinematic polemic. A mother is speaking about her 18-month-old daughter, Mychelle, who became ill one evening with vomiting, diarrhea, and a high fever. At the nearest emergency room, Mychelle is treated by a physician who suspects, rightly, that she has a life-threatening bacterial infection. But rather than give her antibiotics, the doctor calls her insurer, whose physician-gatekeeper tells him that Mychelle is not covered at the hospital and must be taken to another . . .
Are there too many middle class doctors?
Authors: Des Spence
Journal: BMJ (2008)

I have a copy of War and Peace but got so confused by all the names that I stopped at page 6. I fret about the environment but have two cars and fly away for holidays. I want my children to be happy but want them to do well at school. I feel guilty about the problems of the inner city but live in my own suburban ghetto. I am now thoroughly middle class, although I wasn’t always.

Recently the sex selection of medical graduates has …
Gold in erythrocytes, whole blood, and plasma during long-term chrysotherapy.
Authors: S M Pedersen, P M Graabaek
Journal: Annals of the Rheumatic Diseases (1980)

The concentrations of gold in erythrocytes, whole blood, cell-rich plasma, and cell-free plasma were investigated in 17 patients with rheumatoid arthritis undergoing long-term chrysotherapy. Gold estimations were performed with a graphite tube atomic absorption spectrophotometer. Significant quantities of gold were found in isolated erythrocytes of 12 patients. There was no correlation between erythrocyte gold and therapeutic response, plasma gold, and gold in whole blood. Nor did gold in whole blood or plasma show any correlation with therapeutic responses and toxic reaction. However, all patients (3) with toxic reactions had a significantly higher gold concentration in the erythrocytes than the patients without toxic reactions. This result indicates that erythrocyte gold estimations could provide a useful warning of impeding toxic reactions.
Unfairness of Certain Events in the Olympic Games
Authors: T. Khosla
Journal: BMJ (1968)

Boxing, weight-lifting, wrestling, and judo are graded events in that opponents are matched by weight. If protection were to be denied by removing this restriction such sports would overwhelmingly favour the heavyweights. Data on Olympic winners show that many running and jumping events are seriously biased in favour of the very tall. It is suggested that the rules of these events should be revised to include a grading by height. This would remedy an element of unfairness in many athletic contests, beginning at school.
Polyphenols as inhibitors of carcinogenesis.
Authors: C S Yang, M J Lee, L Chen, G Y Yang
Journal: Environmental Health Perspectives (1997)

Many polyphenolic compounds have demonstrated anticarcinogenic activities in animal models. These compounds include flavanone, flavonols, isoflavone, and catechins. In this article, tea catechins will be used as an example to illustrate current research in this area. Many laboratory studies have demonstrated the inhibition of tumorigenesis in animal models by different tea preparations. The animal models include tumorigenesis in the mouse lung, rat and mouse esophagi, mouse forestomach, mouse skin, mouse duodenum, rat small intestine, rat and mouse livers, and rat colon. In most of the studies, the inhibitory activity of tea could be demonstrated when tea preparations were given either during or after the carcinogen treatment period. Black tea was also effective, although the activity was weaker than green tea in some experiments. Decaffeinated tea preparations were also active in many model systems. The molecular mechanisms for these broad inhibitory actions are not fully understood. They are most likely related to the biochemical actions of the tea polyphenols, which include antioxidative activities and inhibition of cell proliferation and of tumor promotion-related activities. The effect of tea consumption on human cancers is not clear in spite of numerous investigations. The bioavailability and pharmacokinetics of tea polyphenols are being studied in animals and humans to provide a basis for more quantitative analyses on the effect of tea on carcinogenesis. More mechanistic and dose-response studies will help us to understand the effects of tea consumption on human carcinogenesis.
MRI of iron oxide nanoparticle-labeled ADSCs in a model of hindlimb ischemia
Authors: Jinbao Qin, Kangan Li, Chen Peng, Xiangxiang Li, Jiaying Lin, Kaichuang Ye, Xinrui Yang, Qingsong Xie, Zunli Shen, Yuqing Jin, Mier Jiang, Guixiang Zhang, Xinwu Lu
Journal: Biomaterials (2013)
Aminopyrine breath test in the prognostic evaluation of patients with cirrhosis.
Authors: C Merkel, M Bolognesi, S Bellon, S Bianco, B Honisch, H Lampe, P Angeli, A Gatta
Journal: Gut (1992)

This prospective study assessed the role of aminopyrine breath test in the prognosis of patients with cirrhosis, and evaluated whether the test provided useful information not included in the Pugh score. During a period of 36 months, 125 patients with biopsy proven liver cirrhosis were included, and followed for up to 48 months (median 17 months). During follow up 43 patients died (20 of liver failure). Survival was univariately related to aminopyrine breath test (p less than 0.02), Pugh score (p less than 0.01), presence of ascites (p less than 0.01), and sex (p less than 0.05). Using Cox9s regression analysis, Pugh score, aminopyrine breath test, and sex, were independent significant predictors of survival. From the Cox9s model a prognostic index was computed. According to a receiver operating characteristic curve analysis, the prognostic index predicting death showed an improvement in area under the curve when compared with a prognostic index calculated excluding aminopyrine breath test, but the improvement did not reach statistical significance (p = 0.12). A similar prognostic index was calculated to predict death from liver failure. Cox9s regression analysis selected aminopyrine breath test, Pugh score, and aetiology as the best set of predictor covariates. According to a receiver operating characteristic curve analysis, a prognostic index cut off value of 2.6 had a 94% sensitivity and a 88% specificity. The prognostic index significantly improved prognostic accuracy when compared with a prognostic index calculated from Pugh score and aetiology, but excluding aminopyrine breath test (p = 0.05). These data disclose that the aminopyrine breath test offers additional prognostic information to the Pugh score, and the prognosis of patients with cirrhosis.
Heart-rate response to standing as a test for automatic neuropathy.
Authors: D J Ewing, I W Campbell, B F Clarke
Journal: BMJ (1978)

Hazard of chemical sympathectomy SIR,-The essential requirement in performing injections with neurolytic solutions is firstly to ensure correct needle placement and secondly to make sure that the solution spreads in the correct tissue plane so as to destroy only the intended nervous tissue.Drs J M B Burn and L Langdon (29 April, p 1143) deny the need for radiological control for chemical sympath- ectomies on the grounds of expediency and on the basis of their own experience.They miss the point that cases of paraplegia, including the one described by Dr R C Smith and others (4 March, p 552), have occurred for the very reason that the operator was unaware of any error in the needle placement or aberrant spread of solution.The potential for in- accurate needle placement is well illustrated in the study by Brechner and Brechner,' who showed that even with technical proficiency check x-rays after final positioning will show up to 400o error in needle placement.When x-ray control with an image in- tensifier is used from the start accurate placement of the needles is very rapid, reducing patient discomfort to a minimum.The satis- factory position of the needles having been seen, subsequent injection of radio-opaque solution then determines the accuracy and extent of spread, allowing for minor adjustments when an occasional intravascular dispersion is seen.We therefore strongly recom- mend, as the safest practice, that all neurolytic injections in the region of the vertebral column should be made under x-ray control.
Editors and their priorities about libel and fraud: We need whistleblowers
Authors: J. S Garrow
Journal: BMJ (2004)

Diagnosis of autism Adequate funding is needed for assessment services2][3] One important additional reason for such provision, which their review does not emphasise, is that well coordinated, multiagency assessment teams for autism spectrum disorders have a better chance of accurately not giving a diagnosis of it.Our multiagency assessment service for autism spectrum disorders has seen 57 patients in the past two years.We request baseline speech and language therapy and (where applicable) educational psychology assessments on the likelihood of autism spectrum disorder in all cases before patients are seen by our team, so as to ensure best use of clinical resources.Despite this approach only 26 patients (46%) deemed to be likely cases of autism spectrum disorder received a positive diagnosis.This is not due to overzealous interpretation of ICD-10 diagnostic criteria (which are increasingly recognised as being in urgent need of review), as we tend, if anything, to err in favour of diagnosis, even if ICD-10 (or DSM-IV) criteria, are not strictly fulfilled.Relevant agencies must receive adequate funding for implementing the national autism plan for children. 3This is to benefit not only the children and their families who are struggling with the often devastating impact of this disorder but also the depressingly high number of children whom, we suspect, will be wrongly, or inaccurately, given diagnoses, if assessment services for autism spectrum disorders do not improve.
Multi-threshold flow 3-D color doppler reconstruction of velocity of the flow acceleration region for quantification of mitral regurgitation: a chronic animal model study
Authors: Xiaokui Li, Michael Jones, Xiang-Ning Li, Arthur D. Zetts, Rosemary A. Rusk, Yoshiki Mori, Crispin H. Davies, Gordon K. Mack, David J. Sahn
Journal: Journal of the American College of Cardiology (2002)
Preoperative Serum Potassium Levels and Perioperative Outcomes in Cardiac Surgery Patients
Authors: Joyce A. Wahr
Journal: JAMA (1999)

Although potassium is critical for normal electrophysiology, the association between abnormal preoperative serum potassium level and perioperative adverse events such as arrhythmias has not been examined rigorously.To determine the prevalence of abnormal preoperative serum potassium levels and whether such abnormal levels are associated with adverse perioperative events.Prospective, observational, case-control study of data collected from 24 diverse US medical centers in a 2-year period from September 1, 1991, to September 1, 1993.A total of 2402 patients (mean [SD] age, 65.1 [10.3] years; 24% female) undergoing elective coronary artery bypass grafting who were not enrolled in another protocol. The study population was identified using systematic sampling of every nth patient, in which n was based on expected total number of procedures at that center during the study period.Intraoperative and postoperative arrhythmias, the need for cardiopulmonary resuscitation (CPR), cardiac death, and death due to any cause prior to discharge, by preoperative serum potassium level.Perioperative arrhythmias occurred in 1290 (53.7%) of 2402 patients, with 238 patients (10.7%) having intraoperative arrhythmias, 329 (13.7%) having postoperative nonatrial arrhythmias, and 865 (36%) having postoperative atrial flutter or fibrillation. The incidence of adverse outcomes was 3.6% for death, 2.0% for cardiac death, and 3.5% for CPR. Serum potassium level less than 3.5 mmol/L was a predictor of serious perioperative arrhythmia (odds ratio [OR], 2.2; 95% confidence interval [CI], 1.2-4.0), intraoperative arrhythmia (OR, 2.0; 95% CI, 1.0-3.6), and postoperative atrial fibrillation/flutter (OR, 1.7; 95% CI, 1.0-2.7), and these relationships were unchanged after adjusting for confounders. The significant univariate association between increased need for CPR and serum potassium level less than 3.3 mmol/L (OR, 3.3; 95% CI, 1.2-9.5) and greater than 5.2 mmol/L (OR, 3.0; 95% CI, 1.1-8.7) became nonsignificant after adjusting for confounders.Perioperative arrhythmia and the need for CPR increased as preoperative serum potassium level decreased below 3.5 mmol/L. Although interventional trials are required to determine whether preoperative intervention mitigates these adverse associations, preoperative repletion is low cost and low risk, and our data suggest that screening and repletion be considered in patients scheduled for cardiac surgery.
Inhibition of Pim1 Kinase Attenuates Respiratory Syncytial Virus (RSV) Re-Infection-Induced Enhanced Airway Hyperresponsiveness (AHR) and Inflammation
Authors: Junyan Han, Wanjiang Zeng, Meiqin Wang, Katsuyuki Takeda, Shigeru Ashino, Yi Jia, Yoo Seob Shin, Erwin W. Gelfand
Journal: Journal of Allergy and Clinical Immunology (2013)
Cholescintigraphic Detection of Cholecystocolonic Fistula and Liver Abscess
Authors: LUIS F. ANEZ, SHIV M. GUPTA
Journal: Clinical Nuclear Medicine (1994)

Diagnosis of a cholecystocolonic fistula with liver abscess was made on a routine colescintigraphy in a patient with fever and hepatic space-occupying lesions of unknown cause. Unexpected scintigraphic findings were later confirmed by endoscopic retrograde cholangiopancreatography and at surgery. Hepatobiliary scintigraphy may serendipitously provide useful information about related organs in the dynamics of hepatic bile flow.