tbuckley/cabot-search huggingface dataset:
Lithium-Pancuronium Interaction
Authors: JAMES W. JEFFERSON
Journal: Annals of Internal Medicine (1978)

Letters and Corrections1 April 1978Lithium-Pancuronium InteractionJAMES W. JEFFERSON, M.D., F.A.C.P.JAMES W. JEFFERSON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-4-577_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their review "Pancuronium Bromide" (Ann Intern Med 88:64-68, 1978), Roizen and Feeley did not mention the interaction of this drug with lithium. In 1974, Borden, Clarke, and Katz (1) described prolonged neuromuscular blockade in a patient taking lithium carbonate who was given pancuronium bromide preoperatively.This interaction has since been confirmed experimentally in dogs in which lithium significantly prolonged pancuronium-induced neuromuscular blockade and the time required for neostigmine to reverse the blockade (2, 3). Similar findings have been reported with succinylcholine (2-4).These observations suggest that neuromuscular blocking agents should be used with caution in patients...References1. BORDENCLARKEKATZ HMH: The use of pancuronium bromide in patients receiving lithium carbonate. Can Anaesth Soc J 21:79-82, 1974 CrossrefMedlineGoogle Scholar2. HILLWONGHODGES GKM: Lithium carbonate and neuromuscular blocking agents. Anesthesiology 46:122-126, 1977 CrossrefMedlineGoogle Scholar3. REIMHERRHODGESHILLWONG FMGK: Prolongation of muscle relaxant effects by lithium carbonate. Am J Psychiatry 134:205-206, 1977 CrossrefMedlineGoogle Scholar4. HILLWONGHODGES GKM: Potentiation of succinylcholine neuromuscular blockade by lithium carbonate. Anesthesiology 44:439-442, 1976 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES W. JEFFERSON, M.D., F.A.C.P.Affiliations: University of Wisconsin Center for Health Sciences Madison, WI 53703 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1978Volume 88, Issue 4Page: 577-577KeywordsCarbonatesDrug interactionsDrugsNeuromuscular blockade ePublished: 1 December 2008 Issue Published: 1 April 1978 PDF downloadLoading ...
Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A2A receptor agonist regadenoson
Authors: Joshua J. Field, Gene Lin, Maureen M. Okam, Elaine Majerus, Jeffrey Keefer, Onyinye Onyekwere, Ainsley Ross, Federico Campigotto, Donna Neuberg, Joel Linden, David G. Nathan
Journal: Blood (2013)
Euhydric hypercapnia increases vasoreactivity of rat pulmonary arteries via HCO transport and depolarisation
Authors: M VANKOVA, V SNETKOV, G KNOCK, P AARONSON, J WARD
Journal: Cardiovascular Research (2004)

To examine whether altered PCO2 or HCO3- at normal pH potentiate agonist-induced vasoconstriction of small pulmonary arteries, and if so to determine the mechanism.Small intrapulmonary arteries (IPA) from rats were mounted on a myograph and PGF2alpha (3 microM)-induced tension recorded before and 40 min after replacing normal bath solution (5% CO2, 24 mM [HCO3-], pH 7.4) with one containing either normal [HCO3-] (24 mM) gassed with 10% CO2 (pH 7.12; hypercapnic acidosis) or high [HCO3-] (48 mM) gassed with 10% CO2 (pH 7.4; euhydric hypercapnia).Hypercapnic acidosis had no significant effect on the response of IPA to PGF2alpha. Euhydric hypercapnia however caused a substantial approximately 5.5-fold potentiation of the response (n=17, p<0.001) in the majority of preparations, whilst 20% of IPA (11 of 58) developed a slow spontaneous vasoconstriction after approximately 20 min. No equivalent responses to euhydric hypercapnia were observed in either mesenteric or renal arteries. Both the potentiation of PGF2alpha-induced vasoconstriction and the spontaneous vasoconstriction in IPA were inhibited by the L-type channel blocker diltiazem (10 microM). The potentiation was also suppressed by DIDS, an inhibitor of anion transporters, removal of extracellular Na+, and anthracene-9-carboxylic acid (A9C; 200 microM), reported to inhibit Ca2+-activated Cl- channels. Inhibition of nitric oxide synthase with L-NAME (100 microM) did not prevent potentiation. Depolarisation with 20 mM [K+] mimicked the effect of euhydric hypercapnia in that it also potentiated the response to PGF(2alpha) (>sixfold, n=6).Euhydric hypercapnia increases vasoreactivity of IPA, but not mesenteric or renal arteries, via a mechanism involving Na+-dependent HCO3- transport, activation of Ca2+-dependent Cl- channels, and subsequent depolarisation. These results may have consequences for patients with CO2-retaining chronic respiratory disease where plasma [HCO3-] is raised following renal compensation, and could explain the increased propensity to pulmonary hypertension and increased mortality in such patients.
Immediate Hypersensitivity To Quinolones: Drug Photodegradation Influences The Specific Basophil Activation
Authors: C. Mayorga, A. Aranda, I. Andreu, M.I. Montaez, A. Ariza, I. Doa, N. Blanca-Lopez, E. Nuin, M.A. Miranda, M. Blanca, M.J. Torres
Journal: Journal of Allergy and Clinical Immunology (2012)
Retrospective study of concussive convulsions in elite Australian rules and rugby league footballers: phenomenology, aetiology, and outcome
Authors: P. R McCrory, P. F Bladin, S. F Berkovic
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objectives:</b> To study the ictal phenomenology, aetiology, and outcome of convulsions occurring within seconds of impact in violent collision sport. <b>Design:</b> Retrospective identification of convulsions associated with concussive brain injury from case records from medical officers of football clubs over a 15 year period. <b>Subjects:</b> Elite Australian rules and rugby league footballers. <b>Main outcome measures:</b> Neuroimaging studies, electroencephalography, neuropsychological test data, and statistics on performance in matches to determine presence of structural or functional brain injury. Clinical follow up and electroencephalography for evidence of epilepsy. <b>Results:</b> Twenty two cases of concussive convulsions were identified with four events documented on television videotape. Convulsions began within 2 seconds of impact and comprised an initial period of tonic stiffening followed by myoclonic jerks of all limbs lasting up to 150 seconds. Some asymmetry in the convulsive manifestations was common, and recovery of consciousness was rapid. No structural or permanent brain injury was present on clinical assessment, neuropsychological testing, or neuroimaging studies. All players returned to elite competition within two weeks of the incident. Epilepsy did not develop in any player over a mean (range) follow up of 3.5 (1-13) years. <b>Conclusions:</b> These concussive or impact convulsions are probably a non-epileptic phenomenon, somewhat akin to convulsive syncope. The mechanism may be a transient traumatic functional decerebration. In concussive convulsions the outcome is universally good, antiepileptic treatment is not indicated, and prolonged absence from sport is unwarranted. <h3>Key messages</h3> Concussive or impact convulsions are a non-epileptic phenomenon They are not associated with structural brain injury Antiepileptic treatment is not indicated In the case of sporting injury, prolonged absence from sport is unwarranted Treatment entails the appropriate management of the associated concussive injury
Leukemic stem cells of acute myeloid leukemia patients carrying NPM1 mutation are candidates for targeted immunotherapy
Authors: V Schneider, L Zhang, L Bullinger, M Rojewski, S Hofmann, M Wiesneth, H Schrezenmeier, M Götz, U Botzenhardt, T F E Barth, K Döhner, H Döhner, J Greiner
Journal: Leukemia (2014)
Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney.
Authors: Y Isaka, Y Fujiwara, N Ueda, Y Kaneda, T Kamada, E Imai
Journal: Journal of Clinical Investigation (1993)

Glomerulosclerosis, a final common lesion of various glomerular diseases, is characterized by mesangial cell proliferation and extracellular matrix (ECM) expansion. TGF-beta and PDGF are known to play a critical role in the regulation of ECM metabolism and mesenchymal cell proliferation, respectively. However, there is little evidence to demonstrate the direct role of each of these growth factors in the pathogenesis of glomerulosclerosis. Using an in vivo transfection technique, we could realize the selective overexpression of single growth factor in the kidney. The introduction of either TGF-beta or PDGF-B gene alone into the kidney induced glomerulosclerosis, although the patterns of action of these growth factors were different; TGF-beta affected ECM accumulation rather than cell proliferation and PDGF affected the latter rather than the former.
Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones.
Authors: R Manetti, F Gerosa, M G Giudizi, R Biagiotti, P Parronchi, M P Piccinni, S Sampognaro, E Maggi, S Romagnani, G Trinchieri
Journal: The Journal of Experimental Medicine (1994)

Interleukin 12 (IL-12) facilitates the generation of a T helper type 1 (Th1) response, with high interferon gamma (IFN-gamma) production, while inhibiting the generation of IL-4-producing Th2 cells in polyclonal cultures of both human and murine T cells and in vivo in the mouse. In this study, we analyzed the effect of IL-12, present during cloning of human T cells, on the cytokine profile of the clones. The culture system used allows growth of clones from virtually every T cell, and thus excludes the possibility that selection of precommitted Th cell precursors plays a role in determining characteristics of the clones. IL-12 present during the cloning procedures endowed both CD4+ and CD8+ clones with the ability to produce IFN-gamma at levels severalfold higher than those observed in clones generated in the absence of IL-12. This priming was stable because the high levels of IFN-gamma production were maintained when the clones were cultured in the absence of IL-12 for 11 d. The CD4+ and some of the CD8+ clones produced variable amounts of IL-4. Unlike IFN-gamma, IL-4 production was not significantly different in clones generated in the presence or absence of IL-12. These data suggest that IL-12 primes the clone progenitors, inducing their differentiation to high IFN-gamma-producing clones. The suppression of IL-4-producing cells observed in polyclonally generated T cells in vivo and in vitro in the presence of IL-12 is not observed in this clonal model, suggesting that the suppression depends more on positive selection of non-IL-4-producing cells than on differentiation of individual clones. However, antigen-specific established Th2 clones that were unable to produce IFN-gamma with any other inducer did produce IFN-gamma at low but significant levels when stimulated with IL-12 in combination with specific antigen or insoluble anti-CD3 antibodies. This induction of IFN-gamma gene expression was transient, because culture of the established clones with IL-12 for up to 1 wk did not convert them into IFN-gamma producers when stimulated in the absence of IL-12. These results suggest that Th clones respond to IL-12 treatment either with a stable priming for IFN-gamma production or with only a transient low level expression of the IFN-gamma gene, depending on their stage of differentiation.
Vaginal Bleeding and Tretinoin Cream
Authors: Charles C. Meurehg
Journal: Annals of Internal Medicine (1990)

Letters and Corrections15 September 1990Vaginal Bleeding and Tretinoin CreamCharles C. Meurehg, MD, Patricia Xóchitl Amelio, MDCharles C. Meurehg, MDSearch for more papers by this author, Patricia Xóchitl Amelio, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-6-483_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: We present the first case in the English literature, to the best of our knowledge, of a person treated with tretinoin cream who had unusual adverse effects.A 64-year-old white American divorced woman, otherwise in good health, was seen in December 1989, complaining of dry skin and superficial wrinkles on her face. Tretinoin cream 0.05% (Retin-A, Ortho Pharmaceutical Corporation, Raritan, New Jersey) was prescribed to be administered nightly in an amount corresponding to a regular-sized pea on each half of the face from the hair line to the chin. A moisturizing cream and a sunscreen were advised...References1. Accutane. Arch Dermatol. 1990;126:307-9. Google Scholar2. KligmanGroveHirose AGR. Topical tretinoin for photoaged skin. J Am Dermatol. 1986;15:836-59. CrossrefMedlineGoogle Scholar3. ZelicksonMottazWeiss AJJ. Topical tretinoin in photoaging: an ultrastructured study. J Cutan Aging Cosmetic Dermatol. 1988;1:41-7. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: American British Cowdray Hospital México City D.F. 01710 México PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByVitamin A: RetinoidsUse of topical tretinoin and the development of noncutaneous adverse events: Evidence from a systematic review of the literatureThe potential for teratogenicity of vitamin A and its congenersDermatological drugs, topical agents and cosmeticsTopical Tretinoin and Vaginal BleedingSophie M. Worobec, MD, George W. Creasy, MD, E. George Thorne, MD 15 September 1990Volume 113, Issue 6Page: 483-483KeywordsHemorrhage Issue Published: 15 September 1990 PDF DownloadLoading ...
Elective single versus double embryo transfer
Authors: A. Templeton
Journal: BMJ (2010)

Transfer of embryos one at a time is as effective and safer

This year, belatedly, Robert Edwards received the Nobel prize for his contribution to the development of human in vitro fertilisation. Louise Brown, the first child to be conceived after the technique was performed, was born in 1978. By the mid-1980s enough procedures were being performed around the world to get an idea of success rates, which became the early obsession. Around this time the main problem with the treatment also came to light—the increased incidence of high order multiple births. Twin birth is now the major problem, and in the linked study (doi:10.1136/bmj.c6945) McLernon and colleagues compared the effect of elective single embryo transfer versus double embryo transfer on pregnancy outcomes⇓.1 



Hank Morgan/Science Photo Library

In the beginning, clinicians transferred too many embryos, often as many as they had available. The initial data seemed to support this practice, with lower pregnancy rates when only one or two embryos were transferred compared with three or more. It was less well understood that the outcome was worse when only one or two embryos were available than when a pool of embryos was available, from which the better ones could be selected.2 Gradually, the …
909 IMPACT OF DEMOGRAPHIC CHARACTERISTICS ON RESPONSE TO PEGYLATED INTERFERON/RIBAVIRIN TREATMENT IN GENOTYPE 2 AND 3 CHC PATIENTS
Authors: G. Spinzi, M. Andreoletti, G. Borroni, A. Bortoli, M.A. Casiraghi, M. Cazzaniga, R. Ceriani, P. Guerzoni, B. Omazzi, S. Paggi, M.G.L. Pich, A. Prada, N. Terreni
Journal: Journal of Hepatology (2013)
A Study of Duroziez's Murmur of Aortic Insufficiency in Man Utilizing an Electromagnetic Flowmeter
Authors: JOHN D. FOLTS, WILLIAM P. YOUNG, GEORGE G. ROWE
Journal: Circulation (1968)

Femoral arterial blood flow was recorded with an electromagnetic flowmeter at the time of open heart surgery on subjects with and without aortic insufficiency. The records demonstrated that subjects with severe aortic insufficiency and Duroziez's murmur had a large amount of retrograde flow in the femoral artery. Those subjects without significant aortic insufficiency and no Duroziez's murmur had little or no backflow. When only a moderate amount of aortic insufficiency was present, the correlation was less satisfactory. In some subjects who had femoral backflow, a second recording was made from the femoral artery after the aortic valve had been replaced, and in these instances there was no longer any measurable backflow. Postoperatively these patients did not have Duroziez's murmur. It is concluded that Duroziez's crural murmur in subjects with aortic insufficiency is associated with retrograde diastolic femoral arterial blood flow.
Abstract 5389: Discovery of small molecule inhibitors of the interaction between PPARγ and SMRT
Authors: Jaeki Min, Ramy Naguib Attia, Leggy A Arnold, Kelly Teske, Michele Connelly, George Lemieux, Kaveh Ashrafi, Anang Shelat, R. Kiplin Guy
Journal: Cancer Research (2014)

Abstract The gamma isoform of the peroxisome proliferator-activated receptor (PPARγ) is a ligand-activated nuclear hormone receptor that plays central roles in regulating adipogenesis and maintaining lipid and glucose homeostasis. PPARγ is the molecular target for the thiazolidinedione (TZD) class of antidiabetic drugs. While clinically efficacious, the TZDs exhibit significant side effects that are mechanistically linked to PPARγ including weight gain, edema, and heart failure. SMRT (silencing mediator of retinoid acid and thyroid hormone receptor) and NCoR (nuclear receptor corepressor) are transcriptional corepressors that are critical for normal PPARγ function and act by repressing PPARγ-mediated transcriptional activity in the absence of agonist ligands. In order to explore an alternate method of activating PPARγ signaling, we designed a biochemical assay for the purpose of high-throughput screening (HTS) to identify inhibitors of the interaction between PPARγ and corepressors from our in-house library compounds (292K), which might act as pharmacological agonists. Herein, we report the use of this method to discover small molecule inhibitors of the corepressor interaction with PPARγ. Following hit validation and evaluation, we identified small molecule inhibitors acting through this novel mechanism that potently induce a cellular response similar to the known PPARγ agonist rosiglitazone. In addition, we also confirmed that our hit compound revealed induced adipogenesis in 3T3-L1 cell and reduced fat storage in C.elegans model. These findings highlight the potential of targeting the interaction of PPARγ and SMRT for the discovery of small molecule agonists of PPARγ. Citation Format: Jaeki Min, Ramy Naguib Attia, Leggy A Arnold, Kelly Teske, Michele Connelly, George Lemieux, Kaveh Ashrafi, Anang Shelat, R. Kiplin Guy. Discovery of small molecule inhibitors of the interaction between PPARγ and SMRT. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5389. doi:10.1158/1538-7445.AM2014-5389
Sputum Protease/Anti-Protease Imbalance Distinguishes Progressive Airflow Limitation in Adolescents with Asthma: CAMP Continuation Study
Authors: R COVAR, P SZEFLER, J MURPHY, A LIU, J SPAHN, R HARBECK, B EFAW, D SUNDSTROM, S SZEFLER
Journal: Journal of Allergy and Clinical Immunology (2008)
The Safety of Trekking at High Altitude After Coronary Bypass Surgery
Authors: Herbert N. Hultgren
Journal: JAMA (1988)

<h3>To the Editor.—</h3> In a recent QUESTIONS AND ANSWERS section,<sup>1</sup>it was asked if a 51-year-old patient with an excellent result from coronary bypass surgery should go on a trek to Nepal up to altitudes of 5760 m (19 008 ft). An exercise treadmill test and a thallium scan had shown "good results" and the patient had been doing long-distance jogging. Two consultants stated that "some risk" would be entailed owing to the low arterial oxygen partial pressure at that altitude and the patient was advised not to go, since "it would be better to err on the side of being safe rather than sorry." I have reservations regarding this advice. If this policy is applied to the many thousands of active individuals who have had coronary bypass surgery, it will result in needless fear and concern about the effect of altitude on the heart and continue to promote
Biology of Normal Luteinizing Hormone-Releasing Hormone Neurons During and After Their Migration from Olfactory Placode
Authors: MARLENE SCHWANZEL-FUKUDA, KAY L. JORGENSON, HUGO T. BERGEN, GARY D. WEESNER, DONALD W. PFAFF
Journal: Endocrine Reviews (1992)

SINCE the initial report that LHRH-expressing neurons migrate during development from their birth place on the medial side of the olfactory placode into the brain (1), two sorts of questions have received additional experimentation and discussion. First, what light does this unusual migration into the developing brain shed on the nature of LHRH-expressing cells, and what are the implications for their normal roles in the adult brain? Second, what would be the implications of migration disturbances for human reproductive physiology, including Kallmann's and other syndromes (see companion paper by Dr. Crowley)? Accordingly, the purposes of this review are to reexamine some of the evidence concerning normal controls over LHRH neurons in light of what these cells are supposed to do in the adult brain; to review the burgeoning evidence that they actually originate in the olfactory pit and migrate into the developing forebrain; and to introduce the subject of Kallmann's syndrome (see companion paper by Dr. Crowley).
Soluble CD40L and Cardiovascular Risk in Women
Authors: Uwe Schönbeck, Nerea Varo, Peter Libby, Julie Buring, Paul M. Ridker
Journal: Circulation (2001)

Background The immune-signaling dyad CD40/CD40L promotes atherogenesis, and patients with unstable angina have elevated plasma levels of soluble CD40L (sCD40L) and membrane-bound CD40L. It is unknown, however, whether elevations of circulating sCD40L precede the onset of acute cardiovascular symptoms. Methods and Results In a prospective, nested case-control evaluation of healthy middle-aged women, mean concentrations of sCD40L at baseline were significantly higher among 130 participants who subsequently developed myocardial infarction, stroke, or cardiovascular death (cases), compared with 130 age- and smoking-matched women who remained free of cardiovascular disease (controls) during a 4-year follow-up (2.86 ng/mL for cases versus 2.09 ng/mL for controls; P =0.02). Women with concentrations above the 95th percentile of the control distribution (&gt;3.71 ng/mL) had a significantly increased relative risk (RR) of developing future cardiovascular events (RR, 3.3; 95% CI, 1.2 to 8.6; P =0.01) that remained after adjustment for usual cardiovascular risk factors (multivariate RR, 2.8; 95% CI, 0.9 to 8.0; P =0.05). Conclusions High plasma concentrations of sCD40L may be associated with increased vascular risk in apparently healthy women.