tbuckley/cabot-search huggingface dataset:
Deletion of <i>Ptpn11</i> (Shp2) in Cardiomyocytes Causes Dilated Cardiomyopathy via Effects on the Extracellular Signal–Regulated Kinase/Mitogen-Activated Protein Kinase and RhoA Signaling Pathways
Authors: Maria I. Kontaridis, Wentian Yang, Kendra K. Bence, Darragh Cullen, Bo Wang, Natalya Bodyak, Qingen Ke, Aleksander Hinek, Peter M. Kang, Ronglih Liao, Benjamin G. Neel
Journal: Circulation (2008)

Heart failure is the leading cause of death in the United States. By delineating the pathways that regulate cardiomyocyte function, we can better understand the pathogenesis of cardiac disease. Many cardiomyocyte signaling pathways activate protein tyrosine kinases. However, the role of specific protein tyrosine phosphatases (PTPs) in these pathways is unknown.Here, we show that mice with muscle-specific deletion of Ptpn11, the gene encoding the SH2 domain-containing PTP Shp2, rapidly develop a compensated dilated cardiomyopathy without an intervening hypertrophic phase, with signs of cardiac dysfunction appearing by the second postnatal month. Shp2-deficient primary cardiomyocytes are defective in extracellular signal-regulated kinase/mitogen-activated protein kinase (Erk/MAPK) activation in response to a variety of soluble agonists and pressure overload but show hyperactivation of the RhoA signaling pathway. Treatment of primary cardiomyocytes with Erk1/2- and RhoA pathway-specific inhibitors suggests that both abnormal Erk/MAPK and RhoA activities contribute to the dilated phenotype of Shp2-deficient hearts.Our results identify Shp2 as the first PTP with a critical role in adult cardiac function, indicate that in the absence of Shp2 cardiac hypertrophy does not occur in response to pressure overload, and demonstrate that the cardioprotective role of Shp2 is mediated via control of both the Erk/MAPK and RhoA signaling pathways.
Chromosome studies in systemic sclerosis with consideration of antibodies to topoisomerase I.
Authors: G J Tsay, J L Lan, S Y Li
Journal: Annals of the Rheumatic Diseases (1992)

Chromosome studies were performed on 11 patients with systemic sclerosis and on 35 control subjects. Nine patients with systemic sclerosis were positive for antibodies to topoisomerase I and two were negative. Of the 1100 metaphases from these 11 patients, 171 (15.5%) had chromosome breaks, compared with 61 of 3500 (1.7%) metaphases from normal control subjects. There were no statistically significant differences in the numbers of chromosome breaks between men and women. The most common fragile site in patients with systemic sclerosis was at 3p14. The karyotype of all patients was normal. Chromosome breaks did not correlate with the presence of antibodies to topoisomerase I.
PHYSICAL THERAPY ASSISTANCE
Authors: Peter J. Peel
Journal: JAMA (1927)

To the Editor:  —An ethical physician does not regard his patient merely as a possible source of income. His interest is broad enough to include the humanities, as he sincerely desires to benefit the sufferers seeking his services. Every year men and women are turning to irresponsibles outside the profession for the help they ought to obtain within it. Lured by the attractive advertising campaigns of osteopaths and chiropractors, many leave their regular family physician and some fall into the hands of unscrupulous quacks. The layman is in no position to make an intelligent choice between the rival claimants.  Osteopaths and chiropractors are openly hostile to the medical profession. Not infrequently actual, and sometimes well nigh irreparable, harm is done to those needing the assistance of medicine or surgery by the antimedical propaganda of these schools. I am a graduate osteopath, and am also a graduate chiropractor. As such I
Syncope: Mechanisms and Management
Authors: Marcie G. Berger
Journal: Annals of Internal Medicine (1998)

Medical Writings15 November 1998Syncope: Mechanisms and ManagementMarcie G. Berger, MDMarcie G. Berger, MDMedical College of Wisconsin, Milwaukee, WisconsinSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-10-199811150-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Syncope: Mechanisms and Management; Grubb BP, Olshansky B; eds. 416 pages. Armonk, NY: Futura; 1998. $89.00. ISBN 0879936835. Order phone 800-877-8761.Field of medicine: Cardiology and neurology.Format: Hardcover book.Audience: Physicians who evaluate and treat patients with syncope, such as internists, family practitioners, pediatricians, geriatricians, and cardiologists.Purpose: To serve as a comprehensive and usable reference on syncope.Content: In a series of critical and focused reviews of the diverse disorders causing syncope, this text provides important insights into the evaluation and management of this common symptom. The initial chapters deal with the scope and impact of the problem ... Author, Article, and Disclosure InformationAffiliations: Medical College of Wisconsin, Milwaukee, Wisconsin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 November 1998Volume 129, Issue 10Page: 839KeywordsCardiology and cardiovascular diseasesCardiovascular therapyElderlyElectrophysiological techniquesNeurologyPathogenesisPopulation statisticsSyncopeSystemic diseasesTreatment guidelines ePublished: 15 August 2000 Issue Published: 15 November 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Inhaled Nitric Oxide for High-Altitude Pulmonary Edema
Authors: Urs Scherrer, Laurent Vollenweider, Alain Delabays, Milos Savcic, Urs Eichenberger, Gian-Reto Kleger, Antonin Fikrle, Peter E. Ballmer, Pascal Nicod, Peter Bärtsch
Journal: New England Journal of Medicine (1996)

Pulmonary hypertension is a hallmark of high-altitude pulmonary edema and may contribute to its pathogenesis. When administered by inhalation, nitric oxide, an endothelium-derived relaxing factor, attenuates the pulmonary vasoconstriction produced by short-term hypoxia.
Paralysis and Other Diseases of the Nervous System, in Childhood and Early Life.
Authors: James Taylor
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
F-18 FDG PET/CT Findings in a Case of Gastric Relapse of Acute Myeloblastic Leukemia
Authors: Kazuyoshi Suga, Yasuhiko Kawakami, Atsuto Hiyama, Koumei Takeda, Yukio Tanizawa, Naofumi Matsunaga
Journal: Clinical Nuclear Medicine (2009)

An isolated extramedullary relapse of acute myelogenous leukemia (AML) after autologous bone marrow transplantation is uncommon. We report the F-18-fluorodeoxyglucose positron emission tomography-computed tomography (F-18 FDG PET/CT) findings in a 50-year-old man with a gastric relapse of AML. This patient had obtained complete remission (CR) of AML in the lumbar bone marrow by autologous bone marrow transplantation and induction chemoradiotherapy 6 years ago, and CR of the meduallary relapse in the bilateral femoral diaphyses by radiotherapy 2 years ago. Regardless of absence of clinical evidence indicative of relapses of AML, FDG PET/CT scan showed the FDG-avid protrusive mass with the maximum standardized uptake of 6.9 in the gastric fundus, which was histologically diagnosed as a relapse by endoscopic biopsy. After radiotherapy to the stomach, the second FDG PET/CT scan showed the disappearance of this FDG-avid gastric mass, and CR of this lesion was endoscopically confirmed. This case indicates that FDG PET/CT scan may be useful for noninvasively detecting a gastric relapse of AML and for monitoring treatment effect.
Just say “No”
Authors: James Craggs
Journal: BMJ (2005)

I was amused by a consent quandary that arose as I was about to anaesthetise a patient. Her wristband with the exaltation “Say No To Drugs” was at odds with my objective to administer potent substances intravenously through the device immediately below it. After a brief discussion, agreement was reached that I should proceed.​proceed.



Figure 1
The Importance of Caloric Restriction in the Early Improvements in Insulin Sensitivity After Roux-en-Y Gastric Bypass Surgery
Authors: Robyn A. Tamboli, Naji N. Abumrad
Journal: Diabetes Care (2010)

We thank Ozer, Abdelnour, and Alva (1) for the recognition of the importance in understanding the immediate metabolic effects of Roux-en-Y gastric bypass (RYGB) surgery. Although our study (2) was not designed to test the effects of type 2 diabetes or degree of obesity on glucose metabolism immediately post-RYGB, these questions are of considerable interest given the proposition that bariatric surgery be performed to treat type 2 diabetes in subjects with a BMI ≤35 kg/m2 (rev. in …
Pumpkin-Seed Impaction
Authors: KOTA L. CHANDRASEKHARA
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 May 1983Pumpkin-Seed ImpactionKOTA L. CHANDRASEKHARA, M.D.KOTA L. CHANDRASEKHARA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-5-675_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I write to report a case of pumpkin-seed impaction in an otherwise healthy patient.A 61-year-old woman presented to the emergency room with rectal pain and constipation of 2 days, duration. Her health was excellent except for mild obesity and she had no history of constipation or rectal disease. She had been on liquid protein diet. About 1 day before the onset of the rectal pain, she had eaten a cup of roasted, unshelled pumpkin seeds. A laxative and enemas had not relieved her constipation. Most examination findings were normal. A rectal examination showed a spastic sphincter... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFecal Impaction in Adults: Report of 30 Cases of Seed Bezoars in the Rectum 1 May 1983Volume 98, Issue 5_Part_1Page: 675-675KeywordsAnal and rectal disordersConstipationDietEmergency departmentObesityProteins Issue Published: 1 May 1983 PDF DownloadLoading ...
CASE OF INFANTILE SCURVY
Authors: H. S. Beadles
Journal: BMJ (1903)

THE following five cases come under the category of doubtful tumours of the breast: CASE I.-A.B., aged 35, was recommended to me by Dr. Haldane eighteen years ago.She was suffering frcm a small swelling in the left breast which was hard and in the neighbourhood of the nipple, and I advised removal of the breast.This was done, the axillary glands being left untouched, and the Datient has remained quite well.The tumour was examined and found to be carcinoma.CASE ii.-R.H., aged 40, was sent to me eight years ago by Dr. Wylie, of Kilmarnock, complaining of a small lump in the right breast.I advised operation, and this was done along with the glands in the axilla.The tumour was examined and found to be carcinoma.She is still quite well.CASE III.-M.C., aged 43, came under my care at the Western Infirmary twenty-five years ago complaining of a hard rimp in the right breast.This was removed without the glands in the axilla.Fifteen years after- wards she returned complaining of a small lump in the other breast.This was removed along with the glands.In both cases the tumours
EEG ABNORMALITIES IN EARLY CHILDHOOD SCHIZOPHRENIA : A DOUBLE-BLIND STUDY OF PSYCHIATRICALLY DISTURBED AND NORMAL CHILDREN DURING PROMAZINE SEDATION
Authors: PHILIP T. WHITE, WILLIAM DEMYER, MARIAN DEMYER
Journal: American Journal of Psychiatry (1964)

EEG tracings during promazine sedation were obtained on 58 children who had autistic or symbiotic childhood psychosis. For comparison EEG's were done under identical conditions on 4 other groups of children: 44 with chronic undifferentiated schizophrenia; 37 non-psychotic children with severe, acting-out behavior disorders; 10 with neuroses; and 13 psychiatrically normal children. Final clinical diagnoses were made without knowledge of the EEG readings as determined for this study, and the EEG's were all placed in random order and read without any knowledge of the clinical diagnosis. EEG abnormalities accepted were focal slowing, focal spikes, paroxysmal spikes and waves, and paroxysmal spikes and waves with independent spikes. Among the 149 patients 51% had abnormal records. None of the psychiatrically normal children had EEG abnormalities. Except for the neurotics, the EEG abnormalities were qualitatively and quantitatively similar in the psychiatric patients. The most frequent abnormalities were irregular paroxysmal spike and wave complexes, often best seen during the transition from wake to sleep. Of the 149 patients, 33% had this complex, either alone or with independent spikes. Although these complexes were most frequent in the autistic-symbiotic group, the incidence was not statistically significantly different from the higher performing, chronic undifferentiated schizophrenics who had communicative speech or the non-psychotic children with acting-out behavior disorders. Of the 58 autistic-symbiotic children, 19% had seizures, which is similar to the 13% seizure incidence in the remaining 91 psychiatric patients. Whether the cerebral dysfunction implied by this study is a primary disorder or is secondary to some factor such as the effect of prolonged anxiety on body chemistry cannot be decided at this time. Nevertheless, an organic concomitant has been demonstrated in 51% of the psychiatrically disturbed children. By increasing the amount of time included in the EEG sample, the incidence of electrical abnormalities might be even higher.
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production
Authors: Gang Chen, Thomas R. Korfhagen, Yan Xu, Joseph Kitzmiller, Susan E. Wert, Yutaka Maeda, Alexander Gregorieff, Hans Clevers, Jeffrey A. Whitsett
Journal: Journal of Clinical Investigation (2009)

Various acute and chronic inflammatory stimuli increase the number and activity of pulmonary mucus-producing goblet cells, and goblet cell hyperplasia and excess mucus production are central to the pathogenesis of chronic pulmonary diseases. However, little is known about the transcriptional programs that regulate goblet cell differentiation. Here, we show that SAM-pointed domain–containing Ets-like factor (SPDEF) controls a transcriptional program critical for pulmonary goblet cell differentiation in mice. Initial cell-lineage–tracing analysis identified nonciliated secretory epithelial cells, known as Clara cells, as the progenitors of goblet cells induced by pulmonary allergen exposure in vivo. Furthermore, in vivo expression of SPDEF in Clara cells caused rapid and reversible goblet cell differentiation in the absence of cell proliferation. This was associated with enhanced expression of genes regulating goblet cell differentiation and protein glycosylation, including forkhead box A3 (Foxa3), anterior gradient 2 (Agr2), and glucosaminyl (N-acetyl) transferase 3, mucin type (Gcnt3). Consistent with these findings, levels of SPDEF and FOXA3 were increased in mouse goblet cells after sensitization with pulmonary allergen, and the proteins were colocalized in goblet cells lining the airways of patients with chronic lung diseases. Deletion of the mouse Spdef gene resulted in the absence of goblet cells in tracheal/laryngeal submucosal glands and in the conducting airway epithelium after pulmonary allergen exposure in vivo. These data show that SPDEF plays a critical role in regulating a transcriptional network mediating the goblet cell differentiation and mucus hyperproduction associated with chronic pulmonary disorders.
Synthesis and biological evaluation of sophocarpinic acid derivatives as anti-HCV agents
Authors: Yinghong Li, Zonggen Peng, Limei Gao, Danqing Song
Journal: Acta Pharmaceutica Sinica B (2014)

Chronic hepatitis C virus (HCV) infection has become a major public health burden worldwide. Twenty-two sophocarpinic acid or matrine derivatives were synthesized and their anti-HCV activities were evaluated in vitro. The structure-activity analysis revealed that (i) sophocarpinic acids with a D-seco 3-ring structure scaffold were more favorable than matrines with a 4-ring scaffold; (ii) the introduction of an electron-withdrawing group on the phenyl ring in 12-N-benzenesulfonyl Δ (βγ) sophocarpinic acids was beneficial for the antiviral activity against HCV. Among them, compounds 9h and 9j exhibited the most potent inhibitory activities on HCV replication with selectivity indies of 70.3 and 30.9, respectively. Therefore, both were selected as antiviral candidates for further investigation.
FIRE-PROOF ASBESTOS SURGICAL DRESSING.
Authors: EVAN O'NEILL KANE
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapies for Lupus Nephritis
Authors: DAVID KAPLAN
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 September 1982Therapies for Lupus NephritisDAVID KAPLAN, M.D.DAVID KAPLAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-3-454_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The report by Dinant and colleagues (1) describing different drug therapies for lupus nephritis contains two important lessons in addition to being an example of a welldesigned clinical trial.The "prednisone only" group apparently received about 20 to 30 mg of prednisone per day (0.3 to 0.4 mg/kg body weight · d), which would be considered grossly inadequate treatment by many. Yet these patients did remarkably well. The dangers of using retrospective controls (2) or comparing data between different centers are well demonstrated.If cytotoxic drugs are marginally better than inadequate treatment, one might wonder about the...References1. DINANT H, DECKER J, KLIPPEL J, BALOW J, PLOTZ P, and STEINBERG A. Alternative modes of cyclophoshamide and azathioprine therapy in lupus nephritis. Ann Intern Med. 1982; 96 (6 Pt 1): 728-36. LinkGoogle Scholar2. POLLAK V, PIRANI C, and KARK R. Effect of large doses of prednisone on the renal lesion and life span of patients with lupus glomerulonephritis. J Lab Clin Med. 1961;57:495-511. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID KAPLAN, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTautomerization of pyrido[2′,1′:2,3]imidazo[4,5-B]quinoline-12-ylcyanide: A DFT studyBibliography 1 September 1982Volume 97, Issue 3Page: 454-454KeywordsBody weightClinical trial reportingDrug therapyDrugsLupus nephritis ePublished: 1 December 2008 Issue Published: 1 September 1982 PDF downloadLoading ...
Rapid activity-induced transcription of Arc and other IEGs relies on poised RNA polymerase II
Authors: Ramendra N Saha, Erin M Wissink, Emma R Bailey, Meilan Zhao, David C Fargo, Ji-Yeon Hwang, Kelly R Daigle, J Daniel Fenn, Karen Adelman, Serena M Dudek
Journal: Nature Neuroscience (2011)
Effects of cellular redox balance on induction of apoptosis by eicosapentaenoic acid in HT29 colorectal adenocarcinoma cells and rat colon in vivo
Authors: P Latham, E K Lund, J C Brown, I T Johnson
Journal: Gut (2001)

<h3>BACKGROUND AND AIMS</h3> Epidemiological evidence suggests n-3 polyunsaturated lipids may protect against colorectal neoplasia. Consumption of fish oil modulates crypt cytokinetics in humans, and crypt apoptosis in animal models. To explore these effects, we investigated involvement of caspase enzymes and cellular redox balance in the induction of apoptosis by eicosapentaenoic acid (EPA) in HT29 cells, and in rat colon in vivo. <h3>METHODS</h3> Survival of HT29 cells grown with EPA in the presence of caspase inhibitors, antioxidants, or buthionine sulphoximine, an inhibitor of glutathione neosynthesis, was determined. The effects of EPA enriched fish oil and glutathione depletion on apoptosis in rat colon were assessed using microdissected crypts. <h3>RESULTS</h3> Treatment of HT29 cells with EPA reduced viable cell number and activated caspase 3, prior to cell detachment. Antioxidants and caspase inhibitors blocked HT29 cell death whereas glutathione depletion increased it. Rats fed fish oil had higher crypt cell apoptosis than those fed corn oil, and glutathione depletion enhanced this effect. <h3>CONCLUSIONS</h3> Incorporation of EPA into colonic epithelial cell lipids increases apoptosis. The results of this study, using both an animal and cell line model, support the hypothesis that this effect is mediated via cellular redox tone, and is sensitive to glutathione metabolism. The data suggest a mechanism whereby polyunsaturated fatty acids may influence the susceptibility of colorectal crypt cells to induction or progression of neoplasia.