tbuckley/cabot-search huggingface dataset:
AN EPIDEMIC OF ACUTE PELLAGRA.
Authors: GEORGE H. SEARCY
Journal: JAMA (1907)

Last summer at the Mount Vernon Insane Hospital, the hospital for colored insane in Alabama, there appeared a few cases of a disease which had been noticed every summer since the patients had been moved there from Tuscaloosa in 1901. Some three or four cases of this disease would occur during each summer and they usually proved fatal. The true nature of the disease was not recognized, and in most instances it was supposed to be a condition of general debility. Early last fall these cases became very numerous, and it was recognized that the disease was epidemic. At the request of the superintendent I went to Mount Vernon to assist the physicians there in studying and controlling the disease. With the assistance of Drs. McCaferty and Somerville, of Mount Vernon, and of Dr. Dyer, of New Orleans, I believe I have worked out the true nature of the disease,
Spontaneous Closure of Ventricular Septal Defects
Authors: J. R. EVANS, R. D. ROWE, J. D. KEITH
Journal: Circulation (1960)

A group of 37 children is described in whom a systolic murmur heard early in life gradually diminished and eventually disappeared. When the patients were first seen, the clinical findings suggested a small ventricular septal defect but no thrill was present and the systolic murmur had a superficial blowing quality with high-frequency vibrations and tended to stop before the second heart sound. Cardiac catheterization demonstrated a small left-to-right shunt at ventricular level in 4 of the patients while the murmur was present; in 1 this was repeated after the murmur had gone and no abnormality could be demonstrated. Cardiac catheterization in other patients with typical disappearing systolic murmurs showed a left-to-right shunt in some but in others this was too small to be detected by routine oxygen studies. A rough correlation was established between the length and intensity of the murmur and the size of the shunt. With angiocardiography and intracardiac phonocardiography the exact site of the ventricular septal defect was localized to the muscular portion of the septum in 4 of the patients. In 1 patient who presented with congestive heart failure, clinical and hemodynamic findings of a large ventricular septal defect diminished over several years and finally disappeared. Children with the specific type of systolic murmur described may be recognized as having a small defect in the muscular ventricular septum. The defect is thought to be gradually reduced in size and ultimately closed by hypertrophy of septal muscle. Spontaneous closure appears to be not uncommon with small ventricular septal defects and may rarely occur with lesions large enough to present with congestive heart failure.
Prevention of Arteriovenous Shunt Clotting
Authors: D. Modai
Journal: JAMA (1974)

Two patients on maintenance hemodialysis developed recurrent clotting of an arteriovenous shunt. Anticoagulant therapy was complicated by massive gastrointestinal bleeding. Very small doses of heparin sodium administered into both shunt limbs maintained patency while bleeding ceased.  (JAMA230:427-430, 1974)
Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans?
Authors: Grégoire Courtine, Mary Bartlett Bunge, James W Fawcett, Robert G Grossman, Jon H Kaas, Roger Lemon, Irin Maier, John Martin, Randolph J Nudo, Almudena Ramon-Cueto, Eric M Rouiller, Lisa Schnell, Thierry Wannier, Martin E Schwab, V Reggie Edgerton
Journal: Nature Medicine (2007)
Solitary Peutz-Jeghers Type Polyp of the Stomach in the Absence of Familial Polyposis Coli in a Teenage Boy
Authors: H. Kuwano, H. Takano, K. Sugimachi
Journal: Endoscopy (1989)

See also: Solitary Peutz-Jeghers Type Polyp of the StomachEndoscopy 1990; 22(03): 153-153DOI: 10.1055/s-2007-1012826
STUDIES OF CORONARY DISEASE IN THE EXPERIMENTAL ANIMAL. II. POLAROGRAPHIC DETERMINATIONS OF LOCAL OXYGEN AVAILABILITY IN THE DOG'S LEFT VENTRICLE DURING CORONARY OCCLUSION AND PURE OXYGEN BREATHING 1
Authors: J. J. Saÿen, W. F. Sheldon, Orville Horwitz, Peter T. Kuo, George Peirce, Harry F. Zinsser, John Mead
Journal: Journal of Clinical Investigation (1951)
Sunbed Use, User Characteristics, and Motivations for Tanning
Authors: Sven Schneider, Katharina Diehl, Christina Bock, Michaela Schlüter, Eckhard W. Breitbart, Beate Volkmer, Rüdiger Greinert
Journal: JAMA Dermatology (2012)

To calculate sunbed use prevalence rates, to investigate the motivations for tanning, and to identify typical target groups for interventions to prevent skin cancer.Cross-sectional, representative, population-based study, primary analysis of the SUN-Study 2012 (Sunbed-Use: Needs for Action-Study).Nationwide telephone survey of the general population in Germany. PARTICIPANTS Study participants (n=4851) aged 14 to 45 years.Frequency of sunbed use and, if applicable, motivational reasons for use, the location of the most recent use, and the available advisory service. Characteristics of typical sunbed users were identified using logistic regression analysis.The overall prevalence of sunbed use was 39.2% (ever users); 14.6% had used a sunbed within the last 12 months (current users). Among minors and persons with skin types I or II, this proportion was 5.2% and 8.9%, respectively. Positive determinants of current sunbed use (quantified as odds ratios [95% CIs]) were female sex (1.97 [1.64-2.37]), immigrant background (1.46 [1.21-1.77]), and full-time (1.93 [1.53-2.43]) or part-time employment (1.44 [1.11-1.85]). The main motivations for tanning were relaxation and increased attractiveness. Sunbeds were mainly used in tanning studios (74.9%), and many users had never been advised about potential health risks (72.8%).The results of this study emphasize the need for more frequent and higher-quality educational interventions to change tanning behavior, particularly among women, people with darker skin, and those with an immigrant background. Owing to their elevated vulnerability, minors and people with pale skin should also be the focus of such interventions.
Happiness, social networks, and health
Authors: A. Steptoe, A. V D. Roux
Journal: BMJ (2008)

Psychosocial determinants of health could be transmitted through social connections

Two linked studies, by Fowler and Christakis (doi:10.1136/bmj.a2338) and Cohen-Cole and Fletcher (doi:10.1136/bmj.a2533), relate to the transmission of health related factors through social networks.1 2 The concept underlying this new field of research is that behaviours may spread over time from one person to another through their immediate and more distant social contacts. Social epidemiology has established the relevance of social connectedness for health, and social network transmission may be one mechanism through which both beneficial and adverse effects are mediated.3 

The article by Fowler and Christakis investigated the social transmission of happiness. Happiness is related to several aspects of wellbeing, including better work performance, greater job satisfaction, good family relationships, and a more satisfying social life,4 but what has it got to do with health? It is no surprise that happiness is reduced when people are ill, and that negative emotional states such as depression and anxiety may influence the prognosis of several physical illnesses. But over recent years it has been suggested that happiness influences future ill health.

A recent meta-analysis of longitudinal observational studies found that measures of happiness, cheerfulness, and related constructs were associated prospectively with reduced mortality, both in initially healthy people and in …
Switch On the Night: Policies for Smarter Lighting
Authors: Luz Claudio
Journal: Environmental Health Perspectives (2009)

Environews | Spheres of Influence The Aspen Recreation Center in Aspen, Colorado, won the 2004 IDA Lighting Design Award.The award recognizes lighting designs that are free of glare, use optimal levels of light, are energy-efficient, and provide pleasant ambience with minimal obtrusive light and contribution to sky glow.Lights that are fully shielded and well spaced keep light where it is directed, minimizing light pollution.
Localized herpes simplex lymphadenitis mimicking large‐cell (Richter's) transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma
Authors: Lija Joseph, Margie A. Scott, Steven A. Schichman, Clive S. Zent
Journal: American Journal of Hematology (2001)

Abstract We report a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) who presented with rapid enlargement of a cervical lymph node due to localized herpes simplex lymphadenitis, which was clinically indistinguishable from large cell (Richter's) transformation. The diagnosis was made by excisional lymph node biopsy, which demonstrated CLL/SLL and zonal necrosis due to herpes simplex infection. The herpetic zone was surrounded by a brisk proliferation of immunoblasts. This case demonstrates the need for excisional biopsy and histologic examination of rapidly enlarging nodes in patients with CLL/SLL. The diagnosis of herpes simplex lymphadenitis in patients with CLL/SLL is especially important because, unlike large cell transformation, the infection usually responds well to treatment. Am. J. Hematol. 68:287–291, 2001. Published 2001 Wiley‐Liss, Inc.
Surrogate end points: studying their benefits, taxonomy, and semantics
Authors: J. K. Aronson
Journal: BMJ (2012)

Yudkin and colleagues highlight some problems in using surrogate end points, largely in diabetes.1 There are three problems with their analysis.

Firstly, they do not clearly distinguish between surrogate end points for benefits and harms. As they suggest, harms rather than surrogates should be studied in trials. Although multiple end points should be studied when surrogates are used to assess …
Renal transplantation: a paradox
Authors: Amir Kazory
Journal: BMJ (2004)

It is barely 2 30 in the morning when the telephone rings: “Nephrologist on call?”

Though half asleep, I recognise the voice of the coordinator of Etablissement Francais de Greffe (French National Institute of Transplantation), and my hand automatically reaches for the pen and paper by the bed. She gets right down to business: “Male, mid-20s, no medical history, group A positive, cause of death—road traffic crash, right kidney…” Fortunately, my pen is able to keep up with this stream of words, even though my brain is not fully awake yet. She continues without taking a breath: “CMV negative, EBV positive, Hep C negative…”

It's only after I put down the receiver that it dawns on …
Massive Retroperitoneal Chondrosarcoma
Authors: MAYOLA W. BOYKIN, MICHAEL F. HARTSHORNE, JOHN M. BAUMAN, MICHAEL A. CAWTHON
Journal: Clinical Nuclear Medicine (1985)

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FDA Bans Sale of Unapproved Cough Suppressants Containing Hydrocodone
Authors: Mike Mitka
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Water-soluble covalent conjugates of bovine serum albumin with anionic poly(N-isopropyl-acrylamide) and their immunogenicity
Authors: Aydan Salman Dilgimen, Zeynep Mustafaeva, Myroslava Demchenko, Tatsuo Kaneko, Yoshihito Osada, Mamed Mustafaev
Journal: Biomaterials (2001)
Bromocriptine-induced reversible lysosomal change and reduction of prolactin and growth hormone messenger RNA in cultured GH3 cell lines
Authors: Keiichi Kamijo, Miyako Sato, Teizo Saito, Tsuyoshi Yabana, Akira Yachi, Nobuyuki Fujii, Takashi Minase
Journal: Endocrine Pathology (1993)
The Physician's Role in Cost Containment
Authors: Basil R. Meyerowitz
Journal: JAMA (1979)

<h3>To the Editor.—</h3> The article by Stephen J. Dresnick, MD, and colleagues, "The Physician's Role in the Cost-Containment Problem" (241:1606, 1979), is a timely one. There has been an explosion of laboratory tests that have been developed and are requested by physicians. The number of times that a physician will write a request for daily determination of electrolyte values without putting an end point to it is most disturbing. Even "arterial blood gases" are requested on a regular repetitive basis without any thought as to how these values may alter the clinical treatment of the patient. It peeves me to see physicians ordering daily bilirubin studies on a patient with obstructive jaundice when nothing has been done that is likely to change the bilirubin level dramatically. Surely one study a week would be adequate. One method of bringing to the attention of the physician the enormous costs of medical care
Supercooling enables long-term transplantation survival following 4 days of liver preservation
Authors: Tim A Berendsen, Bote G Bruinsma, Catheleyne F Puts, Nima Saeidi, O Berk Usta, Basak E Uygun, Maria-Louisa Izamis, Mehmet Toner, Martin L Yarmush, Korkut Uygun
Journal: Nature Medicine (2014)
Combined therapy with dimethylthiourea, diltiazem and amiloride/dimethylamiloride in the ischemic/reperfused heart
Authors: E. Karwatowska-Prokopczuk, E. Czarnowska, A. Prokopczuk
Journal: Cardiovascular Research (1995)

The relative contribution of oxygen free radicals, disturbances in calcium homeostasis and Na+/H+ exchange in the development of injury in the ischemic/reperfused heart was investigated. The study was designed to assess whether these factors initiate independent mechanisms of injury or, alternatively, they share a common mechanism of toxicity.Isolated working rat hearts were subjected to different periods (30-55 min) of global ischemia and then were reperfused for 30 min. We compared the effects of oxygen radical scavengers (10 mM dimethylthiourea, DMTU and 0.6 mM desferrioxamine), inhibitors of Na+/H+ exchange (0.15 mM amiloride and 15 microM dimethylamiloride, DMA) and of 0.1 microM diltiazem, which was used to limit calcium overload, given alone or in combination, on the rate of myocardial injury development (recovery of hemodynamic function, LDH release, incidence of severe arrhythmias and structural integrity of cardiomyocytes were estimated at reperfusion following different periods of ischemia).All interventions studied, when given alone, provided nearly equivalent cardioprotection. DMTU or desferrioxamine when applied in combination with diltiazem provided additive cardioprotection, relatively limited, however, as compared to the remarkable cardioprotection achieved by DMTU or desferrioxamine in combination with amiloride.All mechanisms studied may contribute in an equal manner to the rate of injury development in the ischemic/reperfused heart. The oxygen free radicals-induced myocardial injury may be partially attributed to some disturbance in intracellular calcium homeostasis, possibly calcium overload, whereas the damaging effect of the Na+/H+ exchange activated upon reperfusion is probably largely related to some other mechanism.
Surgeons and Internists
Authors: Susan Rosenthal
Journal: Annals of Internal Medicine (1994)

Letters15 April 1994Surgeons and InternistsSusan Rosenthal, MDSusan Rosenthal, MDRochester General Hospital; Rochester, NY 14621Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-8-199404150-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Commander Hunter and I agree fully that we need to improve communication, and I enthusiastically support the work of the National Surgical Adjuvant Breast and Bowel Project, tumor boards, and multispecialty clinics. The intent of my parable is to decry unilateral action by surgeons, or by any physician, in the management of patients with breast cancer. Author, Article, and Disclosure InformationAffiliations: Rochester General Hospital; Rochester, NY 14621 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1994Volume 120, Issue 8Page: 696-697KeywordsBreast cancerSurgeons ePublished: 15 August 2000 Issue Published: 15 April 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The targeting of anionized polyvinylpyrrolidone to the renal system
Authors: Hiroshi Kodaira, Yasuo Tsutsumi, Yasuo Yoshioka, Haruhiko Kamada, Yoshihisa Kaneda, Yoko Yamamoto, Shin-ichi Tsunoda, Takayuki Okamoto, Yohei Mukai, Hiroko Shibata, Shinsaku Nakagawa, Tadanori Mayumi
Journal: Biomaterials (2003)
Abstract 1540: TNFRs shed by tumor cells inhibit the migration of macrophages.
Authors: Stephen Rego, Rachel Helms, Alexander De Piante, Amritha Kidiyoor, Amanda Lance, Pinku Mukherjee, Didier Dréau
Journal: Cancer Research (2013)

Abstract Breast tumor cells transform their microenvironment through the expression of pro-tumor molecules critical to their progression and metastasis. Among the targets of tumor cell secretions are macrophages, which play an essential role in tumor progression. Although macrophages possess tumor cell killing abilities, the tumor-associated macrophages (TAMs) display primarily pro-tumor functions including increasing tumor angiogenesis and promoting tumor cell invasion. Breast tumor cells shed multiple membrane-bound proteins including their tumor necrosis factor (TNF) receptors through TACE/ADAM17 activities. The release of sTNFR1/2 serves a decoy sequestering TNF and preventing TNF-driven apoptosis of tumor cells. Additionally, tumor derived sTNFR1/2 also modulate TNF effects on macrophages including their migration. Here, we investigated whether sTNFRs were shed by cells present within the breast tumor microenvironment and determined their effects on macrophage migration in response to TNF. TNF and sTNFRs concentrations were measured in murine mammary tumor and normal cells including monocytes/macrophages. In addition, the migration of murine monocytes toward TNF in the presence tumor derived soluble factors (TDSFs) was determined by transwell assays. The effects of TDSFs obtained with and without the sheddase inhibitor TAPI-0 treatment on monocyte/macrophage migration were also assessed. No TNF was detected in the TDSFs of tumor cells or secretions from normal epithelial cells. In contrast, stroma cells especially macrophages expressed high levels of TNF (p&amp;lt;0.001). sTNFR2 concentrations were variable in TDSFs and significantly decreased in TDSFs obtained following TAPI-0 treatment (p&amp;lt;0.05). Macrophages migrated toward TNF in a dose-dependent manner (p&amp;lt;0.05). While the addition of TDSFs prevented the macrophage migration toward TNF, the use of TDSFs collected following TAPI-0 treatment had no effects of the macrophage migration toward TNF (p&amp;lt;0.05). These results support the modulatory role of sTNFRs secreted by tumor cells in macrophage responses to TNF. [This works is supported by grants from the Department of Defense Era of Hope research program (BC044778) and the National Science Foundation EFRI program (CBE0736007)]. Citation Format: Stephen Rego, Rachel Helms, Alexander De Piante, Amritha Kidiyoor, Amanda Lance, Pinku Mukherjee, Didier Dréau. TNFRs shed by tumor cells inhibit the migration of macrophages. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1540. doi:10.1158/1538-7445.AM2013-1540
Potential of dendritic cell immunotherapy for relapse after allogeneic hematopoietic stem cell transplantation, shown by WT1 peptide‐ and keyhole limpet hemocyanin‐pulsed, donor‐derived dendritic cell vaccine for acute myeloid leukemia
Authors: Toshio Kitawaki, Norimitsu Kadowaki, Tadakazu Kondo, Takayuki Ishikawa, Tatsuo Ichinohe, Satoshi Teramukai, Masanori Fukushima, Yasunari Kasai, Taira Maekawa, Takashi Uchiyama
Journal: American Journal of Hematology (2007)

Abstract Induction of leukemia‐specific immune responses is a promising treatment for acute myeloid leukemia. A 58‐year‐old woman received Wilms' tumor 1 (WT1) peptide‐ and keyhole limpet hemocyanin (KLH)‐pulsed, donor‐derived dendritic cell (DC) vaccination for AML relapse after allogeneic stem cell transplantation. The vaccination induced immune responses to the naïve antigen KLH, whereas definitive immune responses to WT1 were not detected. Leukemia gradually progressed despite of vaccination. This study indicates that DC vaccination can induce an antigen‐specific immune response in a patient after allogeneic stem cell transplantation, thus representing a viable strategy to induce antigen‐specific immune responses in such patients. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.
Clinical outcome in IL-10– and IL-10 receptor–deficient patients with or without hematopoietic stem cell transplantation
Authors: Karin R. Engelhardt, Neil Shah, Intan Faizura-Yeop, Dilara F. Kocacik Uygun, Natalie Frede, Aleixo M. Muise, Eyal Shteyer, Serkan Filiz, Ronnie Chee, Mamoun Elawad, Britta Hartmann, Peter D. Arkwright, Christopher Dvorak, Christoph Klein, Jennifer M. Puck, Bodo Grimbacher, Erik-Oliver Glocker
Journal: Journal of Allergy and Clinical Immunology (2012)