tbuckley/cabot-search huggingface dataset:
The patient's journey: Living with locked-in syndrome
Authors: Nick Chisholm, Grant Gillett
Journal: BMJ (2005)

This is the story of Nick, who has lived with locked-in syndrome since 2000. His narrative is interspersed with information on his condition and a commentary on the clinical and ethical issues that arise in locked-in syndrome.

This is a story of my experiences since a terrible accident. I started the story in hospital and then added to it over the years. I had my accident on the rugby field on 29 July 2000 about 2 00 pm, just before the ball was thrown into a line-out. It just felt like a simple case of concussion (everything went blurry). I staggered to the sideline, the coach asked me “What's wrong”? He said I told him I just felt sick and to put me back on the field in 10 minutes. Then I collapsed and was rushed to hospital (unconscious) in an ambulance with the staff struggling to keep me alive.

After three days, doctors thought I was all right and were going to send me home. Then it started: I nearly collapsed again, taking a shower (I became extremely dizzy and lost my balance). For days, the specialists didn't know what was wrong with me. My girlfriend at the time went mad at the specialists to do something.

### The diagnosis

After six days of going in and out of seizures, after what seemed like all the tests known to man, they said I had had several strokes of the brain stem and then one major one, which left me with the extremely rare condition known as locked-in syndrome (box 1), not able to do anything.

Words can't describe the situation I have been left in—but this is as close as I can get it: an extremely horrific experience that I wouldn't wish on my worst enemy. The incredibly immense frustration levels at …
Long‐lasting allergic contact blepharoconjunctivitis to phenylephrine eyedrops
Authors: N. Raison‐Peyron, A. Du Thanh, P. Demoly, B. Guillot
Journal: Allergy (2009)

Allergic contact dermatitis due to mydriatic eyedrops is rare despite extensively used by ophthalmologists. Phenylephrine is responsible for most of the cases in the literature. We reported two other cases due to phenylephrine eyedrops with an unusual evolution characterized by chronic debilitating blepharoconjunctivitis.
THE CAUSAL ROLE OF PLASMA ALBUMIN DEFICIENCY IN EXPERIMENTAL NEPHROTIC HYPERLIPEMIA AND HYPERCHOLESTEREMIA 1
Authors: Ray H. Rosenman, Meyer Friedman, Sanford O. Byers, Malcolm K. Smith
Journal: Journal of Clinical Investigation (1956)

Previous studies ( 1-8) from this laboratory have indicated that the hypercholesteremia and hyperlipemia occurring in the experimental ne- phrotic syndrome induced in rats by injection of anti-rat kidney seruim are due primarily to some intravascular "trapping" phenomenion whereby the animal appears unable to remove either endog- enously-produced or dietary-derived cholesterol and lipid from the plasma with its customary efficiency.However, since renal changes seem- ingly initiate the total nephrotic syndrome, it seems probable that this "trapping" of cholesterol and lipid which occurs in the plasma in this syndrome is related in some manner to such renal changes.In the present study, an attempt was made to de- termine the nature of this relationship.The ob- servations herein reported suggest (a) that the hypercholesteremia and the hyperlipemia observed in the experimental nephrotic syndrome are initi- ated and maintained by the external renal loss of some plasma constituent, and (b) that this sub- stance specifically is albumin. I. The Relationship of Nlephrotic HVperlipenetiaand Hypercholesteremlia to Renal Dawnage and External Renal Excretion Methods Drastic alteration in renal function was accomplished in several series of experimental and control male rats (Long-Evans strain) by 1) nephrectomy, 2) bilateral ligation of renal pedicles, 3) bilateral ureteral ligation, and 4) ureter-vena caval anastomosis.1) Conttrol rats.Pooled rabbit anti-rat kidney serum (AKS) was prepared as described by Heymann and Lund (9).
Ranitidine and Hepatitis
Authors: GEORGE N. KARACHALIOS
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 October 1985Ranitidine and HepatitisGEORGE N. KARACHALIOS, M.D.GEORGE N. KARACHALIOS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-4-634_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Ranitidine, a recently marketed H2-receptor antagonist, is considered to be effective in the treatment of peptic ulcer disease and other hypersecretory states (1). Most patients tolerate the drug well, and the minor adverse effects seen during ranitidine therapy seldom make it necessary to withdraw treatment (1). Two recent reports have described possible cases of ranitidine-induced hepatotoxicity (2, 3). We report the case of a patient who developed hepatitis during treatment with ranitidine.A 65-year-old man was hospitalized for minor upper gastrointestinal tract bleeding. He had a long history of a duodenal ulcer and had been treated with...References1. BROGDENCARMINEHEELSPEIGHTAVERN RARTG. Ranitidine: a review of its pharmacology and therapeutic use in peptic ulcer disease and other allied diseases. Drugs. 1982;24:267-303. CrossrefMedlineGoogle Scholar2. SOUZA LIMA M. Hepatitis associated with ranitidine. Ann Intern Med. 1984;101:201-8. LinkGoogle Scholar3. BLACKSCOTTKANTER MWR. Possible ranitidine hepatotoxicity. Ann Intern Med. 1984;101:208-10. LinkGoogle Scholar4. BARRPIPER GD. Possible ranitidine hepatitis. Med J Aust. 1981;2:421. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Kalamata General Hospital Kalamata Greece PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNephrotoxicity and Hepatotoxicity of Histamine H2 Receptor AntagonistsPossible Cholestatic Injury From Ranitidine With a Review of the LiteratureFamotidine-Induced Mixed Hepatocellular Jaundice 1 October 1985Volume 103, Issue 4Page: 634-635KeywordsDrug therapyDuodenal ulcersGastrointestinal tractHemorrhageHepatitis APeptic ulcers Issue Published: 1 October 1985 PDF DownloadLoading ...
Association of serum proprotein convertase subtilisin/kexin type 9 with carotid intima media thickness in hypertensive subjects
Authors: Chan Joo Lee, Yong-ho Lee, Sahng Wook Park, Kwang Joon Kim, Sungha Park, Jong-Chan Youn, Sang-Hak Lee, Seok-Min Kang, Yangsoo Jang
Journal: Metabolism (2013)
The radiation accident in Georgia: Clinical appearance and diagnosis of cutaneous radiation syndrome
Authors: Petra Gottlöbera, Guntram Bezoldc, Lutz Weberc, Patrick Gourmelond, Jean Marc Cossete, Wolfgang Bährenb, Hans J. Haldb, Theodor M. Fliednerf, Ralf U. Petera,c
Journal: Journal of the American Academy of Dermatology (2000)
Rapidly progressive cutaneous vasculitis in a patient with chronic myelomonocytic leukemia
Authors: Adam M. Rosen, Kenneth Haines Iii, Martin S. Tallman, David Hakimian, Rosalind Ramsey‐Goldman
Journal: American Journal of Hematology (1995)

Abstract This case report reviews the unique development of a vasculitic syndrome involving medium‐sized arteries in a man with chronic myelomonocytic leukemia (CMMoL). This case has many features in common with cutaneous polyarteritis nodosa (CPAN), and this may represent the first instance in which CPAN developed in the setting of CMMoL.
Unrecognized standard of care imposed by court
Authors: M. V. O'Hern
Journal: JAMA (1974)

EVERY week, there are many court decisions that have an impact on the practice of medicine. These decisions are currently reported, in summary, in<i>The Citation</i>, a newsletter published twice a month by the Office of the General Counsel, American Medical Association. Some of these decisions are of such special importance that they deserve the wider publicity that can be obtained through the pages ofThe Journal. Trial court decisions, which are of little precedent value and are subject to reversal, are omitted. Selected decisions are usually restricted to those of the highest state or federal court. It should be remembered, however, that a decision by a court in one state is not necessarily controlling elsewhere. <h3>Unrecognized Standard of Care Imposed by Court</h3> Conformity to a well-established standard of medical care accepted around the world did not protect ophthalmologists in the state of Washington from liability for a patient's visual
A Brief History of the Internship
Authors: Dennis K. Wentz
Journal: JAMA (1984)

The internship is the focal point of the transition of medical student to physician. From its origins in hospital apprenticeships, this experience of professionalization and initiation into direct patient responsibility has followed an erratic path. Modern US internships began in the late 19th century, and evolution of many of their characteristics has been determined more by socioeconomic-political issues than by consideration of educational objectives. The recent move to incorporate internships into residency programs is currently being reconsidered because there is a new appreciation of the role that the internship experience can play in the professional maturation of the physician.
Response to ‘Renal microvascular and tubular injuries in type II diabetic nephropathy’
Authors: Daniela Verzola, Maria T. Gandolfo, Franco Ferrario, Maria P. Rastaldi, Barbara Villaggio, Francesco Gianiorio, Massimo Giannoni, Laura Rimoldi, Francesca Lauria, Mariano Mij, Giacomo Deferrari, Giacomo Garibotto
Journal: Kidney International (2008)
Iothalamate Sodium I 125 vs Cyanocobalamin Co 57 as a Measure of Glomerular Filtration Rate in Man
Authors: Carl F. Anderson
Journal: JAMA (1968)

The simultaneous renal clearances of iothalamate sodium I 125, cyanocobalamin Co 57, and inulin were compared in 19 patients with a variety of renal diseases. The renal clearances of both iothalamate sodium I 125 and cyanocobalamin Co 57 are not statistically different from the clearance of inulin or from each other. Plasma protein binding was insignificant with iothalamate sodium I 125 but averaged 22% with cyanocobalamin Co 57 with a considerable variation between patients. These observations, as well as a lower cost per study, suggest that iothalamate sodium I 125 is an excellent radioactive material to substitute for inulin clearance when measuring the glomerular filtration rate in man.
Erythema Nodosum due to Pasteurella pseudotuberculosis
Authors: D. S. Wilkinson, T. W. Turner, N. S. Mair
Journal: BMJ (1969)

Two children developed erythema nodosum due to Pasteurella pseudotuberculosis. Neither case showed typical signs of P. pseudotuberculosis infection, but this cause was shown by positive agglutination tests. It is suggested that this organism is a more common cause of erythema nodosum than is at present recognized.
Case 3-1975
Authors: Lot B. Page, Richard B. Cohen
Journal: New England Journal of Medicine (1975)

Presentation of CaseA 52-year-old man was admitted to the hospital because of vomiting.Three years previously hypertension was found, and alpha-methyldopa and diazepam were prescribed. Five days before admission he came to the clinic because of midepigastric pain that occurred one hour after eating and was relieved by milk and antacid. Examination disclosed that the blood pressure was 180/110 mm Hg; there were no other abnormal findings. An x-ray film of the chest (Fig. 1) showed left ventricular enlargement and dilatation of the ascending portion of the aorta; the lungs appeared clear except for prominent cylindrical markings in the . . .
The term BPH is misused
Authors: Paul Abrams
Journal: BMJ (2008)

OBJECTIVE:To assess the specificity of Composite Cerebellar Functional Severity Score (CCFS) for cerebellar dysfunction in patients with multiple sclerosis (MS). BACKGROUND:Cerebellar involvement of MS patients is a negative prognostic factor for disability progression. Sensitive Ataxia rating scales with high specificity for tremor and limb ataxia are essential for determining outcome measures in clinical trials. The CCFS, developed for genetic forms of cerebellar ataxias, is a simple and validated method for assessing cerebellar ataxia in the upper limbs, adjusted for age and correlated with severity of cerebellar impairment. DESIGN/METHODS:We investigated 110 consecutive patients with multiple sclerosis followed in our MS clinic between May and September 2013. Clinical data including Expanded Disability Status Scale (EDSS) and CCFS score were collected. RESULTS:EDSS and CCFS were gathered from 105 patients, 5 patients not able to perform CCFS because of major clinical severity. The average age of the population was 44.6±11.0 (22-73), the age at disease onset was 33.2± 10.4 (13-62). Patients were classified as remitting relapsing (RRMS) in 67[percnt], secondary progressive (SPMS) in 23[percnt] and as primary progressive (PPMS) in 10[percnt]. The mean EDSS and cerebellar FSS of EDSS were 3.5±2.4 (0-8) and 0.9 ±1.3 (0-4), respectively. Forty five patients had a cerebellar functional severity score (FSS) 蠅1 (1-3). The average of the CCFS score was 0.933±0.120(0.781-1,376) with significantly lower data in RRMS patients and was not correlated with age at MS onset and disease duration. The CCFS score was significantly correlated with EDSS (r=0.63, p&lt;0.0001) and with cerebellar FSS (r=0.796 (p&lt;0.0001). The patients, characterized by association of EDSS蠅4 and cerebellar impairment, had the significantly worse CCFS score. CONCLUSIONS:The CCFS is a simple and specific method for quantification assessment of cerebellar involvement in MS over a wide range of severity, and would be useful for quantifying cerebellar progression of MS in future therapeutic trials. <b>Disclosure:</b> Dr. Tchikviladzé has nothing to disclose. Dr. Corvol has nothing to disclose. Dr. Lubetzki has received personal compensation for activities with Roche Diagnostics, Vertex Pharmaceuticals, Novartis, and Genzyme as a consultant and/or speaker. Dr. Papeix has received personal compensation for activities with Teva Neuroscience, Novartis, Laboratoires Servier, and Roche Diagnostics Corporation. Dr. Durr has received personal compensation for activities with Pfizer, Inc. Dr. Tezenas Du Montcel has nothing to disclose.
Risk of hepatocellular carcinoma in chronic hepatitis B: Assessment and modification with current antiviral therapy
Authors: George V. Papatheodoridis, Henry Lik-Yuen Chan, Bettina E. Hansen, Harry L.A. Janssen, Pietro Lampertico
Journal: Journal of Hepatology (2015)

In the treatment of chronic hepatitis B (CHB), the ultimate goal is preventing hepatitis B virus (HBV)-associated liver disease, including hepatocellular carcinoma (HCC). Recently published studies show that in CHB patients treated with the currently recommended first-line nucleos(t)ide analogs (NAs) entecavir or tenofovir, annual HCC incidences range from 0.01% to 1.4% in non-cirrhotic patients, and from 0.9% to 5.4% in those with cirrhosis. In Asian studies including matched untreated controls, current NA therapy consistently resulted in a significantly lower HCC incidence in patients with cirrhosis, amounting to an overall HCC risk reduction of ∼30%; in non-cirrhotic patients, HCC risk reduction was overall ∼80%, but this was only observed in some studies. For patients of Caucasian origin, no appropriate comparative studies are available to date to evaluate the impact of NA treatment on HCC. Achievement of a virologic response under current NA therapy was associated with a lower HCC risk in Asian, but not Caucasian studies. Studies comparing entecavir or tenofovir with older NAs generally found no difference in HCC risk reduction between agents, except for one study which used no rescue therapy in patients developing lamivudine resistance. Overall, these data indicate that with the current, potent NAs, HCC risk can be reduced but not eliminated, probably due to risk factors that are not amenable to change by antiviral therapy, or events that may have taken place before treatment initiation. Validated pre- and on-therapy HCC risk calculators that inform the best practice for HCC surveillance and facilitate patient counseling would be of great practical value.
Reauthorizing AIDS Care
Authors: Mike Mitka
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Work Experience of Cardiac Patients Following Referral to a Work Evaluation Unit
Authors: SAMUEL W. STEIN, GEORGE E. ALTMAN
Journal: Circulation (1965)

A study of 537 patients referred to the Cardiac Work Evaluation Unit of Boston during the 5-year period from 1955 to 1960 has been undertaken. The present report concerns the 375 individuals with coronary or hypertensive heart disease evaluated during the period of study. Of the total number, 76 were considered unemployable and 299 (80 per cent) employable. Of the employable, 64 (21 per cent) are known to have died subsequently. Of those for whom some follow-up was obtained, 82 per cent returned to work or continued working after initial evaluation. When last known, 64 per cent of those still alive were still working. The mean duration of follow-up for this series was 4.5 years. Consideration of the factors that may influence the subsequent employment experience indicated that successful employment was significantly more frequent for subjects below the age of 50, with favorable current cardiac classification (IIB or better), with apparently good motivation, or after a period of unemployment less than 1 year, than for patients in whom any of these factors was unfavorable. Certain specific medical factors, such as heart size, history of previous myocardial infarctions, and blood pressure, had a less constant relation to subsequent employment, though they did have some relation to the medical prognosis. There was no indication in the present study that employment influenced the mortality statistics.
Estimate of the global volume of surgery in 2012: an assessment supporting improved health outcomes
Authors: Thomas G Weiser, Alex B Haynes, George Molina, Stuart R Lipsitz, Micaela M Esquivel, Tarsicio Uribe-Leitz, Rui Fu, Tej Azad, Tiffany E Chao, William R Berry, Atul A Gawande
Journal: The Lancet (2015)
Treatment allocation by minimisation
Authors: P. Sedgwick
Journal: BMJ (2013)

Researchers assessed the effectiveness of adenoidectomy in children with recurrent upper respiratory tract infections. An open randomised controlled trial study design was used. The intervention was immediate adenoidectomy, with or without myringotomy. Control treatment was a strategy of initial watchful waiting.1

The trial participants were 111 children aged 1-6 years with recurrent upper respiratory tract infections who had been selected for adenoidectomy. Participants were recruited from 13 sites, including 11 general hospitals and two academic centres. Children were allocated to treatment using minimisation to control for age (<2 and ≥2 years) and site of recruitment. Length of follow-up was a maximum of 24 months.

The primary outcome measure was the number of upper respiratory tract infections per person year during follow-up. No significant difference was seen between treatment groups, with 7.91 episodes of upper respiratory tract infections per person year in the adenoidectomy group and 7.84 in the control group (difference in incidence rate 0.07, 95% confidence interval −0.70 to 0.85). It was concluded that in children selected for adenoidectomy with recurrent upper respiratory tract infections, immediate surgery confers no clinical benefits over a strategy of initial watchful waiting.

Which of the following statements, if any, are true?

Statements a and c are true, whereas b is false.

The purpose of the trial was to assess the effectiveness of adenoidectomy in children with recurrent upper respiratory tract infections. The control treatment was a strategy of initial watchful waiting. The proposed sample size was small. If …
Alterations in the Local Myocardial Motion Pattern in Patients Suffering From Pressure Overload Due to Aortic Stenosis
Authors: M. Stuber, M. B. Scheidegger, S. E. Fischer, E. Nagel, F. Steinemann, O. M. Hess, P. Boesiger
Journal: Circulation (1999)

Background —MR tissue tagging allows the noninvasive assessment of the locally and temporally resolved motion pattern of the left ventricle. Alterations in cardiac torsion and diastolic relaxation of the left ventricle were studied in patients with aortic stenosis and were compared with those of healthy control subjects and championship rowers with physiological volume-overload hypertrophy. Methods and Results —Twelve aortic stenosis patients, 11 healthy control subjects with normal left ventricular function, and 11 world-championship rowers were investigated for systolic and diastolic heart wall motion on a basal and an apical level of the myocardium. Systolic torsion and untwisting during diastole were examined by use of a novel tagging technique (CSPAMM) that provides access to systolic and diastolic motion data. In the healthy heart, the left ventricle performs a systolic wringing motion, with a counterclockwise rotation at the apex and a clockwise rotation at the base. Apical untwisting precedes diastolic filling. In the athlete’s heart, torsion and untwisting remain unchanged compared with those of the control subjects. In aortic stenosis patients, torsion is significantly increased and diastolic apical untwisting is prolonged compared with those of control subjects or athletes. Conclusions —Torsional behavior as observed in pressure- and volume-overloaded hearts is consistent with current theoretical findings. A delayed diastolic untwisting in the pressure-overloaded hearts of the patients may contribute to a tendency toward diastolic dysfunction.