tbuckley/cabot-search huggingface dataset:
Ascending Aortic Dissection Causing Unilateral Absence of Perfusion on Lung Scanning
Authors: D F WORSLEY, D B COUPLAND, B C LENTLE, P CHIPPERFIELD, J I MARSH
Journal: Clinical Nuclear Medicine (1993)

A case of an ascending aortic dissection occurring in a patient 8 years after an aortic valve replacement is presented. The patient's initial clinical presentation was thought to be due to pulmonary embolism, and a ventilation- perfusion lung scan demonstrated mismatched absence of perfusion to the entire right lung. Aortography and findings at surgery demonstrated a type A dissection of the ascending aorta. The anatomic relationship of the aorta and pulmonary artery and their common tunica adventitia make the right pulmonary artery susceptible to extrinsic compression after aortic dissection. Although uncommon, dissection of the ascending aorta needs to be considered in patients who have undergone previous aortic valve surgery and demonstrate mismatched unilateral absence of perfusion to the right lung. Because anticoagulation is contraindicated in patients with acute aortic dissection, confirmation of the diagnosis with angiography usually is required.
T-cell receptor– and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue
Authors: Rachel David, Liang Ma, Aleksandar Ivetic, Aya Takesono, Anne J. Ridley, Jian-Guo Chai, Victor L. Tybulewicz, Federica M. Marelli-Berg
Journal: Blood (2008)
An assessment of anxiety and dermatology life quality in patients with atopic dermatitis
Authors: None LINNET, None JEMEC
Journal: British Journal of Dermatology (1999)

Anxiety is a prevalent psychological factor associated with atopic dermatitis (AD). AD patients generally suffer from a high anxiety level, and psychological treatment documents a positive effect on the anxiety level, as well as the course and management of the disease. The Dermatology Life Quality Index (DLQI) has been suggested as a relevant clinical measure in AD. This study investigated the relationship between the severity of AD, dermatological life quality and anxiety. Thirty-two adults suffering from AD were examined using the Severity Scoring of AD Index (SCORAD), the DLQI and the Spielberger State-Trait Anxiety Index (STAI). Twenty-two healthy controls were examined using the DLQI and STAI. Results showed that the AD group had higher anxiety and lower dermatological life quality than the control group. In the AD group a significant positive correlation was found between SCORAD and DLQI and between DLQI and STAI. However, no correlation was found between SCORAD and STAI. The results suggest that: (i) both severity of eczema and anxiety are important for dermatological life quality; (ii) psychological inferences should not be made from the severity of eczema, but from the psychological measures, and vice versa; and (iii) both dermatological and psychological assessment is important in AD.
A New Technique for Insertion of the Colonoscope Through the Ileocaecal Valve
Authors: N. Gabrielsson, S. Granqvist
Journal: Endoscopy (1977)

At colonoscopy it is important to examine the distal part of ileum in inflammatory diseases particularly. Different techniques for insertion of the colonoscope into the ileum have been described. In our experience these methods require considerable skill and practice. We have therefore worked out a technique for easier access to the ileum with a colonoscope. A closed biopsy forceps is used for identification of the ileocaecal valve by dislodging the upper lip. The forceps is manoeuvred through the ostium and then the colonoscope can be inserted into the ileum with the forceps as a guide.
Indoor environmental factors associated with house‐dust‐mite allergen (Der p i) levels in south‐eastern Australian houses
Authors: M. H. Garrett, B. M. Hooper, M. A. Hooper
Journal: Allergy (1998)

Background Eighty households in the Latrobe Valley, Victoria, Australia, were sampled for house‐dust‐mite allergen (Der p 1). Allergen levels vary greatly between houses within climate regions. The reasons for this are not well understood. Methods House‐dust‐mite allergen samples were collected on six occasions between March 1994 and February 1995, All participating households contained at least one child between 7 and 14 years with a total of 148 subjects, 53 of whom were asthmatic. A detailed house survey was performed during every sampling visit, and a dwelling questionnaire was completed. Relative humidity was measured at the time of sample collection. Results The median bed allergen level was 30 ng/g during the first sampling period. Significantly higher allergen levels were associated with wool bedding and inner‐spring mattresses (p &lt; 0.001). As estimated from a multiple linear regression model, up to 70% reduction in bed allergen levels may be achieved by avoiding wool bedding and inner‐spring mattresses. Other risk factors for high allergen levels included high indoor relative humidity, presence of substantial visible mould growth, brick cladding, and concrete slab foundation of the house. Conclusions Avoiding wool bedding and replacing inner‐spring mattresses with foam could substantially reduce bed allergen levels.
Private hospitals look to NHS for elective operations as private medical insurance falls
Authors: N. Hawkes
Journal: BMJ (2012)

The number of NHS patients treated in privately run hospitals rose by nearly 11% in 2011-12, data from the NHS Health and Social Care Information Centre show. The admissions covered common elective procedures such as cataract, knee, and hernia operations, carpal tunnel surgery, endoscopy, and sigmoidoscopy.

In 2011-12 there were eight million non-emergency admissions in the NHS in England, with private providers accounting for 345 200 of them (4.3%), up from 312 324 (4%) in 2010-11. No reliable figures exist for earlier years because, the centre said, data from the independent sector had only recently reached a level sufficient to provide a meaningful comparison. 

The rise reflects, among other changes, the increasing willingness of private providers to negotiate deals with the NHS at a time when income from patients with private medical insurance has been in decline. Across the private sector as whole NHS patients accounted in 2010-11 for a quarter of revenues: £1.1bn of a total of £4.1bn.

While NHS work is not very profitable for private providers, as it must be carried out within the same tariff as is paid to NHS hospitals, it has helped fill a gap left by declining numbers of patients with …
White paper commits UK government to national care service but does not specify funding mechanism
Authors: C. Dyer
Journal: BMJ (2010)

Plans for a comprehensive personal care service for England that is free for all who need it have been unveiled by the UK government, creating what ministers trumpeted as “the biggest change to the welfare state since the creation of the NHS.”

A white paper unveiled by the health secretary, Andy Burnham, commits Labour to a national care service (NCS) for disabled people and elderly people, mirroring the free healthcare service provided by the NHS, which was set up in 1948.

At present, those with the funds must pay for their own social care, selling their homes if necessary—a situation Mr Burnham described as “a tax on dementia.”

But the reforms would not come into effect before 2015, …
DERMATOMYOSITIS: A REPORT OF A CASE
Authors: R. B. PILCHER
Journal: British Journal of Dermatology (1950)

Journal Article DERMATOMYOSITIS: A REPORT OF A CASE Get access R. B. PILCHER, M.B., B.S. R. B. PILCHER, M.B., B.S. Royal Prince Alfred Hospital and the Department of Medicine, University of Sydney Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 62, Issue 12, 1 December 1950, Pages 494–497, https://doi.org/10.1111/j.1365-2133.1950.tb14352.x Published: 01 December 1950
The Surgical Aspects of Hemorrhage from Peptic Ulcer
Authors: George J. Heuer
Journal: New England Journal of Medicine (1946)

A STUDY of the patients who have entered the surgical wards of the New York Hospital with serious hemorrhage from the gastrointestinal tract shows that the large majority were the victims of duodenal or gastric ulcer, whereas a minority presented a variety of other pathologic conditions. I was asked to discuss the large subject of hemorrhage from the gastrointestinal tract in its relation to surgery, but since it is obvious that I cannot cover so large a field in the short time at my disposal, I shall confine myself to the surgical aspects of hemorrhage from peptic ulcer, which, in . . .
Decreased salivary epidermal growth factor in rheumatoid disease: a possible mechanism for increased susceptibility to gastric ulceration.
Authors: S M Kelly, J Crampton, J O Hunter
Journal: BMJ (1990)

Mean (SD) number of injections and insulin dose during days at home and during westward and eastward travel Insulin dose (units) Injections per day Intermediate actingt Short acting Total Westward travel: Normal day at home 3-3 (1-1) 23-7 (9-9) 11-3 (9-2) 35-0 (11 1) Day offlight 48(1-1) 25-1 (96) 175 (8.5)* 426(11 1)* Eastward travel: Normaltwodaysathome 6 4(1 8) 48-5 (19 2) 23 4 (6 8) 71 9(22 1) Dayofflightandnextday 63(14) 407(144)* 242(132) 649(190)* *p<0.001Compared with value on normal days at home (unpaired t test).tIncludes basal insulin dose in two patients using insulin pumps.
Adolescent Suicide
Authors: Charles R. Keith
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outpatient Management of Diabetes Mellitus with Patient Education to Increase Dietary Carbohydrate and Fiber
Authors: June Stevens, Mary B Burgess, Donald L Kaiser, C Michael Sheppa
Journal: Diabetes Care (1985)

The impact of patient education on dietary fiber intake, diabetes control, and serum lipids was examined in patients with non-insulin-dependent diabetes mellitus. Customary outpatient personnel and procedures were used to teach three diet plans: (1) the American Diabetes Association (ADA) diet, (2) the ADA diet modified to increase high-fiber, high-carbohydrate foods (IF), and (3) the IF diet supplemented with oat bran (IFOB). A control group was instructed on foot care to provide teaching visits. Fifty-two patients were recruited from an outpatient clinic and studied over a 6-wk period. Subjects were of low socioeconomic status and had completed a mean of 8.3 yr of education. Patients instructed to increase their intake of high-fiber foods reported a doubling of fiber intake and tolerated the diets well. Increased fiber and carbohydrate intake and decreased fat intake were associated with reductions in fasting plasma glucose levels. Increased fiber intake was also associated with reductions in total serum cholesterol and high-density lipoprotein cholesterol levels. Changes in fiber, carbohydrate, and fat intake were unrelated to changes in weight, serum insulin levels, or hemoglobin A1c levels over the study period.
IgA deposition and synthesis in alcoholic liver injury
Authors: D. R. Triger
Journal: Hepatology (1988)

Immunoglobulin deposition in alcoholic and non-alcoholic liver disease was studied using an indirect immunoperoxidase technique. A continuous pattern of IgA deposition, with IgA outlining the sinusoids, was shown to be a specific and sensitive marker for liver disease caused by alcohol in both cirrhotic and non-cirrhotic livers. The sensitivity was lowest in cases of alcoholic disease showing fatty change alone. In one case it was possible to show the absence of IgA in liver disease caused by a drug, which was histologically indistinguishable from alcoholic hepatitis.
Health effects of Chernobyl.
Authors: S. Dutton, F. Harris
Journal: BMJ (1989)

<b>2244</b> <h3><b>Objectives</b></h3> To estimate the error in <sup>90</sup>Y microsphere delivery vial exposure rate measurement, and assess its impact on the percent of activity delivered calculation. <h3><b>Methods</b></h3> Linear correlation analysis of background-corrected exposure rate (mR/h) at 30 cm from the vial (V), measured with a calibrated ion chamber survey meter, versus activity (GBq) from a dose calibrator calibrated for assaying <sup>90</sup>Y vials, was performed using the data from our first fifty-seven hepatocellular carcinoma (HCC) <sup>90</sup>Y microspheres liver brachytherapy treatments. Employing the mR/h computed from the linear correlation function as the correct value, the difference between measured and true (ΔV) was calculated. The resulting difference (Δ%D) in estimated percent of activity delivered (%D=100 × [V - residual waste jar mR/h] / V), using measured versus true V, was then computed. A p value ≤ 0.05 was considered statistically significant. <h3><b>Results</b></h3> Excellent correlation of mR/h vs. GBq was observed (y=1.682x, r=0.993, p&lt;0.0001), over a range of GBq from 0.51 to 6.98 and corresponding mR/h from 0.90 to 11.97. The ΔV was not significant (Mean %ΔV: -1.42±6.70, Range: -34.12 to 10.11, p=0.34). The corresponding Δ%D was also not significant (Mean: -0.06±0.27, Range: -1.43 to 0.73, p=0.094), over the range of %D (Mean: 96.8±6.4, Range: 64.0 to 100%). <h3><b>Conclusions</b></h3> Based on measured - fit residuals, the <sup>90</sup>Y microspheres vial activity mR/h "assay" appears to be within 10% of true. Since the estimated %D tends to be very high in HCC patients (e.g., 49 of 57 ≥ 95% and 53 of 57 ≥ 90% in this cohort), the equation approaches V/V most of the time, and thus the effect of an error in V is generally negligible. On the other hand, the one ΔV outlier (-34.1%) suggests a large error is possible. If the true %D was 80 for that treatment, the error would have resulted in a %D of 70 and thus an apparent misadministration (&gt; 20% difference from prescribed), suggesting that minimizing inaccuracy in V is prudent (e.g. by minimizing variation in the measurement geometry)
Abstract 3098: MiRNA-145 is a master regulator of the hallmarks of thyroid cancer.
Authors: Myriem Boufraqech, Lisa Zhang, Meenu Jain, Neelam Gulati, Naris Nilubol, Mio Kitano, Yin Xiong, Electron Kebebew
Journal: Cancer Research (2013)

Abstract microRNA-145 (miR-145) in an important member of the family of microRNAs which are downregulated in several types of tumors. However, miR-145 expression and function in thyroid cancer and in cellular differentiation is unknown. In our study, we performed miRNA profiling in normal, benign and malignant thyroid cancers including undifferentiated tumors with validation of differentially expressed miRNAs by quantitative RT PCR. We found significant downregulation of miR-145 in differentiated and undifferentiated thyroid cancer. We performed functional studies in thyroid cancer cell lines and found that miR-145 decreases cell proliferation, induces cell cycle arrest, decreases cell invasion and targets the PI3K/Akt pathway, one of the most commonly activated pathways in thyroid cancer and which is associated with epithelial-mesenchymal transition (EMT). Overexpression of miR-145 in cell lines also decreased the expression of EMT markers vimentin and N-cadherin. Furthermore, inhibition of miR-145 in normal primary thyroid cultured cells decreased NIS and PAX8 expression, key regulators of thyroid cell differentiation. miRNA-145 expression in tumor tissue was inversely correlated with VEGF serum levels in the same patients and overexpression of miR-145 in vitro decreased angiogenesis and VEGF secretion. MiRNA-145 has important regulatory effects on the hallmarks of thyroid cancer cells and thus may be involved in thyroid cancer progression. Citation Format: Myriem Boufraqech, Lisa Zhang, Meenu Jain, Neelam Gulati, Naris Nilubol, Mio Kitano, Yin Xiong, Electron Kebebew. MiRNA-145 is a master regulator of the hallmarks of thyroid cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3098. doi:10.1158/1538-7445.AM2013-3098
Complaints handling must improve in UK trusts
Authors: Andrew Cole
Journal: BMJ (2005)

the treatment, although an estimated 6.5 million people worldwide would benefit from it.Latin America and the Caribbean have 62% of the estimated 465 000 people who would benefit already receiving treatment; followed by East, South, and South East Asia (14% of 1.1 million); Europe and Central Asia (13% of 160 000); sub-Saharan Africa (11% of 4.7m); and North Africa and the Middle East (5% of 75 000).The heaviest burden of disease is in sub-Saharan Africa, where half a million people are now receiving treatment, a threefold increase in the past 12 months."We are going to get to three million, though it will take a little longer than we had wanted," Jim Yong Kim, director of the WHO Department of HIV/AIDS, said in an interview.
Gated Tc-99m Sestamibi SPECT Versus Stress–Rest SPECT in Detecting Coronary Artery Disease
Authors: UGO PAOLO GUERRA, FRANCESCO GIACOMUZZI, FERNANDO DI GREGORIO, JEROEN J. BAX, GIAN AUGUSTO SLAVICH, PAOLO MARIA FIORETTI
Journal: Clinical Nuclear Medicine (1999)

It is possible to simultaneously evaluate wall thickening and perfusion abnormalities with radionuclide techniques that use tracers such as Tc-99m MIBI. We presumed that detection of wall thickening by gated MIBI SPECT imaging in the presence of a stress-induced perfusion defect correlates with reversibility of that defect on resting images. Therefore, the aim of our study was to analyze, in patients without myocardial infarction, resting wall thickening and stress perfusion imaging as an alternative to conventional stress-rest imaging.The patients (n = 44) underwent an exercise (n = 37) or pharmacologic (n = 7) stress protocol. All patients had previous coronary angiography within 3 months. Stress-rest MIBI SPECT and gated MIBI SPECT studies were analyzed by visual scoring. The sensitivity and specificity of segmental analysis of both stress-rest MIBI SPECT perfusion and gated MIBI SPECT studies for the overall detection of coronary artery disease were, respectively, 71% and 96%. For patient evaluation for detection of coronary artery disease, stress-rest MIBI SPECT perfusion and gated MIBI SPECT studies showed a sensitivity rate of 96% for both and specificity rates of 84% and 79%, respectively.Our data revealed close agreement between reversible perfusion defects on stress-rest MIBI SPECT scans and significant wall thickening on gated MIBI SPECT stress images in patients without previous myocardial infarction (95%). Gated MIBI SPECT stress, without resting studies, which provide an assessment of wall motion and wall thickening, potentially allows stress defect reversibility to be evaluated in patients without previous myocardial infarction.
Interleukin‐1 affects the function of cultured human thyroid cells
Authors: Å. Krogh Rasmussen, K. Bech, U. Feldt‐Rasmussen, S. Poulsen, I. Holten, M. Ryberg, C. A. Dinarello, K. Siersbæ‐Nielsen, T. Friis, K. Bendtzen
Journal: Allergy (1988)

Cytokines are peptide hormones essential for cellular communication in the immune response. The purpose of this study was to investigate the influence of cytokines, especially recombinant interleukin 1β (rIL‐1β), on human thyroid cells. Thyroglobulin (Tg) was measured by a double antibody radioimmunoassay, and cyclic AMP (cAMP) by a competitive protein binding assay. Supernatants from unstimulated and phytohaemagglutinin‐stimulated blood nononuclear cells were added to human thyroid cells cultured in monolayers. A dose‐dependent inhibition of the secretion of Tg and cAMP was demonstrated. Both subcultured and primary cultured cells incubated with rIL‐1β at pharmacological levels (10 −1 −10 2 U/ml) exhibited an inhibition of Tg and cAMP secretion, while at physiological levels (10 −5 ‐10 −3 U/ml), the secretion of Tg was enhanced. The similar stimulation of cAMP was demonstrated in subcultures. These in vitro studies suggest that IL‐1β may play a role in the pathogenesis of autoimmune thyroid diseases. Further, the stimulations at low concentrations indicate that IL‐1β may regulate the function of the thyroid gland under physiological conditions.
Randomized, multicenter, phase 2 study (EVOLUTION) of combinations of bortezomib, dexamethasone, cyclophosphamide, and lenalidomide in previously untreated multiple myeloma
Authors: Shaji Kumar, Ian Flinn, Paul G. Richardson, Parameswaran Hari, Natalie Callander, Stephen J. Noga, A. Keith Stewart, Francesco Turturro, Robert Rifkin, Jeffrey Wolf, Jose Estevam, George Mulligan, Hongliang Shi, Iain J. Webb, S. Vincent Rajkumar
Journal: Blood (2012)
Comparison of the effects of levocetirizine and loratadine on histamine‐induced wheal, flare, and itch in human skin
Authors: G. F. Clough, P. Boutsiouki, M. K. Church
Journal: Allergy (2001)

Background: This randomized, double‐blind, crossover study compared the effects of the R ‐enantiomer of cetirizine, levocetirizine, with those of loratadine on the wheal, flare, and itch response to histamine in human skin. Methods: Levocetirizine (5 mg), loratadine (10 mg), or placebo was taken orall_y 4 h before the intradermal injection of histamine (20 µl, 100 µM) or the control vehicle into the forearm skin of healthy volunteers. Flare areas were assessed by scanning laser Doppler imaging before and at 30‐s intervals for a period of 9 min. Wheal areas were measured by planimetry at 10 min. Itch was scored every 30 s with a visual analogue scale. Results: After placebo administration, the mean peak flare area was 23.01±1.94 cm 2 , the wheal area 248±27 mm 2 , and the cumulative itch score 28.8±4.6% (mean±SEM). Levocetirizine reduced the flare, wheal, and itch by 60%, 68%, and 91%, respectively (all_ P &lt;0.001, Student's t ‐test for paired data). The effects of loratadine were variable and not statisticall_y significant. Conclusions: Levocetirizine (5 mg) is a potent inhibitor of the effects of histamine in human skin with an efficacy that exceeded that of loratadine (10 mg) when single doses of the drugs were administered 4 h before the test.