tbuckley/cabot-search huggingface dataset:
Pulmonary hypertension in primary Sjogren's syndrome.
Authors: M T Hedgpeth, D W Boulware
Journal: Annals of the Rheumatic Diseases (1988)

The clinical course of a patient with pulmonary hypertension associated with Sjögren9s syndrome is reported. The clinical features and outcome of this case are compared with those of two other reported cases in the Spanish and Japanese published work. Thus far, pulmonary hypertension has not been reported with primary Sjögren9s syndrome in English publications. These three cases suggest that the development of pulmonary hypertension in primary Sjögren9s syndrome is uncommon but should be included as part of the clinical spectrum.
Haemostatic, fibrinolytic and lipid parameters in relation to the initial manifestation of coronary artery disease
Authors: Rajiv Narang, Helen Phillipou, Piet Meijer, Saro Niththyananthan, Dimitri Tousoulis, David Lane, Cornelis Kluft, Edward Tuddenham, Graham Davies
Journal: Journal of the American College of Cardiology (1996)
scientific articles have hardly changed in 50 years
Authors: Richard Smith
Journal: BMJ (2004)

<h3>ABSTRACT</h3> Measures of brain activity through functional magnetic resonance imaging (fMRI) or Electroencephalography (EEG), two complementary modalities, are ground solutions in the context of neuro-feedback (NF) mechanisms for brain rehabilitation protocols. While NF-EEG (real-time neurofeedback scores computed from EEG signals) have been explored for a very long time, NF-fMRI (real-time neurofeedback scores computed from fMRI signals) appeared more recently and provides more robust results and more specific brain training. Using simultaneously fMRI and EEG for bi-modal neurofeedback sessions (NF-EEG-fMRI, real-time neurofeedback scores computed from fMRI and EEG) is very promising to devise brain rehabilitation protocols. However, fMRI is cumbersome and more exhausting for patients. The original contribution of this paper concerns the prediction of bi-modal NF scores from EEG recordings only, using a training phase where EEG signals as well as the NF-EEG and NF-fMRI scores are available. We propose a sparse regression model able to exploit EEG only to predict NF-fMRI or NF-EEG-fMRI in motor imagery tasks. We compared different NF-predictors steaming from the proposed model. We showed that predicting NF-fMRI scores from EEG signals adds information to NF-EEG scores and significantly improve the correlation with bi-modal NF sessions, compared to classical NF-EEG scores.
Comparison of an intragastric method of estimating acid output with the pentagastrin test in normal and duodenal ulcer subjects.
Authors: T V Taylor, J B Elder, P C Ganguli, I E Gillespie
Journal: Gut (1978)

Using Fordtran9s technique but substituting the meat extract Oxo for the steak meal we investigated gastric acid secretion in eight control subjects and nine patients with chronic duodenal ulcer. Intragastric titration was performed using a double lumen tube measuring the pH in the stomach every three minutes and adjusting it to 5.5 throughout the test by infusing 0.3-M sodium bicarbonate. On a separate day a pentagastrin test was performed using a conventional gastric aspiration technique. In the eight control subjects the mean acid output after pentagastrin was 13.7 +/- 2.1 (SEM) mmol/h, whereas the mean hourly acid output measured by intragastric titration was 20.1 +/- 3.1. The greater response to Oxo than to pentagastrin in the controls (deltaAO = + 46%) was significant (P less than 0.01). This is in contrast with our duodenal ulcer patients whose mean hourly acid outputs were 22.7 +/- 4.4 and 23.0 +/- 4.4 mmol/h in response to pentagastrin and Oxo respectively (r = 0.95). The findings, while clearly at variance with those of Fordtran and Walsh (1973), are more in keeping with the concept of increased endogenous secretory drive in duodenal ulcer patients compared to normal subjects.
Efficacy of peginterferon ALFA-2A (40KD) (PEGASYS) plud ribavirin for 24 weeks in genotype 1 patients with chronic hepatitis C followed by mono or combination therapy for 22 weeks: Preliminary analysis of an open, multicenter, randomized trial
Authors: J.P. Bronowicki, D. Ouzan, T. Asselah, H. Desmorat, J.P. Zarski, J. Foucher, M. Bourliere, C. Renous, A. Tran, P. Melin, C. Hezode, M. Chevallier, M. Bouvier, J.M. Pawlotsky, I. Lonjon-Domanec
Journal: Journal of Hepatology (2003)
Trends in Subthreshold Psychiatric Diagnoses for Youth in Community Treatment
Authors: Daniel J. Safer, Thiyagu Rajakannan, Mehmet Burcu, Julie M. Zito
Journal: JAMA Psychiatry (2014)

Patterns and trends of subthreshold DSM-IV mental health diagnoses for youth within US community treatment settings merit systematic research.To quantify and assess temporal patterns of DSM-IV diagnoses not otherwise specified (NOS) among youth during physician office visits.We conducted a retrospective study using psychiatric diagnostic data from the US National Ambulatory Medical Care Survey and the National Hospital Ambulatory Medical Care Survey (n = 16,295) from 1999 through 2010, combined in 4-year intervals. Using diagnoses from visits to physicians, we compared trends of the proportional distribution of the major psychiatric diagnoses with subthreshold criteria (coded as NOS) with proportions of diagnoses reaching full criteria.Specific common psychiatric diagnoses NOS compared with full-criteria psychiatric diagnoses.Between the 1999-2002 and 2007-2010 periods, the proportion of US medical visits reporting DSM-IV NOS psychiatric diagnoses compared with the proportion reporting full psychiatric diagnostic criteria for youth aged 2 to 19 years rose prominently for major mood diagnostic subtypes. Among all visits for mood disorders, NOS visits grew proportionally 1.5-fold from 45.3% in the 1999-2002 period to 68.8% in the 2007-2010 period (P < .001). Among visits for bipolar disorder, NOS visits increased more than 18-fold, from 3.6% in the 1999-2002 period to 72.6% in the 2007-2010 period (P < .001). In addition, anxiety disorder NOS increased from 44.6% in the 1999-2002 period to 58.1% in the 2007-2010 period. Overall, NOS visits constituted 35.0% of the total psychiatric visits in 2007-2010 but represented 55.9% when attention-deficit/hyperactivity disorder codes were excluded.The expansion of subthreshold (NOS) DSM-IV diagnoses of mood disorder, bipolar disorder, and anxiety disorder in youth that has occurred since 1999 in all likelihood will continue in the DSM-5 era unless administrative efforts are made to alter this practice. Unspecified diagnoses lack research reliability and potentially increase the likelihood of off-label prescribing of psychotropic medication.
CELLULAR ANTI-GP120 CYTOLYTIC REACTIVITIES IN HIV-1 SEROPOSITIVE INDIVIDUALS
Authors: KentJ. Weinhold, ThomasJ. Matthews, PaulM. Ahearne, AlphonseJ. Langlois, H.Kim Lyerly, DouglasS. Tyler, KimoC. Stine, DavidT. Durack, DaniP. Bolognesi
Journal: The Lancet (1988)
Synergistic effects of fluticasone propionate and salmeterol on in vitro T-cell activation and apoptosis in asthma
Authors: Elisabetta Pace, Rosalia Gagliardo, Mario Melis, Stefania La Grutta, Maria Ferraro, Liboria Siena, Giovanni Bonsignore, Mark Gjomarkaj, Jean Bousquet, Antonio M. Vignola
Journal: Journal of Allergy and Clinical Immunology (2004)
Estimation of Relative Bioavailability of Lead in Soil and Soil-Like MaterialsUsing Young Swine
Authors: Stan W. Casteel, Christopher P. Weis, Gerry M. Henningsen, William J. Brattin
Journal: Environmental Health Perspectives (2006)

In this article we summarize the results of a series of studies that measured the relative bioavailability (RBA) of lead in a variety of soil and soil-like test materials. Reference material (Pb acetate) or Pb-contaminated soils were administered orally to juvenile swine twice a day for 15 days. Blood samples were collected from each animal at multiple times during the course of the study, and samples of liver, kidney, and bone were collected at sacrifice. All samples were analyzed for Pb. We estimated the RBA of a test material by fitting mathematical models to the dose-response curves for each measurement end point and finding the ratio of doses that gave equal responses. The final RBA for a test material is the simple average of the four end point-specific RBA values. Results from 19 different test materials reveal a wide range of RBA values across different exposure materials, ranging from 6 to 105%. This variability in RBA between different samples highlights the importance of reliable RBA data to help improve risk assessments for Pb in soil. Although the RBA value for a sample depends on the relative amounts of the different chemical and physical forms of Pb present, data are not yet adequate to allow reliable quantitative predictions of RBA from chemical speciation data alone.
Dutch Cancer Care Is (Was?) Well Supported
Authors: C. Vanchieri
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Dutch Cancer Care Is (Was?) Well Supported Get access Cori Vanchieri Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 17, 1 September 1993, Page 1372, https://doi.org/10.1093/jnci/85.17.1372 Published: 01 September 1993
The Sanctity of Social Life: Physicians' Treatment of Critically III Patients
Authors: Susan Crawford
Journal: JAMA (1978)

Sociologist Diana Crane has addressed social and ethical problems of the dying in America and the painful search for ethical guidelines by the medical profession. Based on seven years of research, some 3,000 questionnaires, extensive interviews with physicians, and contacts on the ward, the book is a systematic study of the choices physicians actually make when confronted with terminally ill or irreparably handicapped patients. The criteria that physicians use in deciding to treat critically ill patients are investigated, along with the extent to which these deviate from traditionally held norms. There appears, for example, to be a strongly held norm in the medical profession against direct killing, even where the individual has no capacity whatsoever to function in social relationships. Crane examines the circumstances under which physicians actively bring about death, ie, practice euthanasia. Variables affecting physicians' decisions are analyzed: age, culture, religion, medical school affiliation, specialization, and departmental policies.
Production and modulation of interleukin 6 synthesis by synoviocytes derived from patients with arthritic disease.
Authors: J T Rosenbaum, R Cugnini, D C Tara, S Hefeneider, J C Ansel
Journal: Annals of the Rheumatic Diseases (1992)

Interleukin 6 (IL-6) is a potent cytokine, the biological activities of which include the stimulation of immunoglobulin secretion, T cell activation, induction of the acute phase response, activation of megakaryocytes, and pyrogenicity. These biological activities make it a plausible contributor to rheumatoid arthritis. The ability of synoviocytes to synthesise this potential mediator of inflammation was tested. Cultures of fibroblast-like cells were established from joint tissue from patients with rheumatoid arthritis, degenerative joint disease, or trauma. Supernatants from synoviocytes from each diagnostic category contained IL-6-like activity as detected in a B9 plasmacytoma cell proliferation assay. Supernatants from IL-1 stimulated synoviocytes from patients with rheumatoid arthritis (n = 5) contained an average of 70,000 U/ml IL-6. Western blot analysis confirmed that these supernatants contained peptides that reacted with a highly specific antibody to IL-6. A cDNA probe specific for IL-6 hybridised with mRNA derived from synoviocytes representative of each disease state. Interleukin 6 mRNA expression increased by culturing synoviocytes in the presence of 10% calf serum, IL-1 (30 U/ml), insulin (166 ng/ml), or basic fibroblast growth factor (16 ng/ml). In contrast, dexamethasone (10(-6) mol/l) suppressed the ability of IL-1 to increase the expression of IL-6 mRNA. Recombinant IL-6 itself did not detectably upregulate its own message. The regulation of production of IL-6 by synoviocytes may be important in the pathogenesis of joint inflammation.
Influence of antigen on immune complex behavior in mice.
Authors: D S Finbloom, D B Magilavy, J B Harford, A Rifai, P H Plotz
Journal: Journal of Clinical Investigation (1981)

To explore the possibility that the behavior of immune complexes can, under some circumstances, be directed by the antigen, we have studied the behavior of complexes of identical size made with the glycoproteins, orosomucoid (OR), and ceruloplasmin: or with their desialylated derivatives, asialo-orosomucoid (ASOR) and asialo-ceruloplasmin. Such desialylated proteins are rapidly removed from the circulation by a hepatic cell receptor for galactose, the sugar exposed upon removal of sialic acid. Mixtures of 125I-goat anti-ASOR with either ASOR or OR and mixtures of 125I-rabbit anti-OR with either ASOR or OR form complexes identically. The complexes were separated by density gradient centrifugation and injected intravenously into C3H mice. Blood clearance and hepatic uptake of the OR complexes and ASOR complexes were markedly different. T 1/2 for the goat OR complexes exceeded 300 min, whereas that for the ASOR complexes was 15 min. More detailed studies using rabbit complexes of various sizes revealed that light rabbit complexes behaved similarly to the goat complexes. The light rabbit OR complexes were cleared slowly, with only 18% found in the liver at 60 min, whereas the light rabbit ASOR complexes were cleared much more rapidly, with 62% found within the liver by 30 min. This rapid clearance was completely suppressed by a prior injection of a blocking dose of ASOR, which implies uptake by a galactose-mediated mechanism on hepatocytes. As the size of the rabbit complexes increased, so did the rate of Fc receptor-mediated clearance. Heavy rabbit OR complexes were cleared more rapidly than light OR complexes but not so rapidly as heavy ASOR complexes. The clearance and hepatic uptake of the heavy OR complexes were markedly suppressed by a prior injection of heat-aggregated gamma globulin, a known Fc receptor-blocking agent (45% hepatic uptake without and 6% with aggregated gamma globulin). The heavy rabbit ASOR complexes exhibited inhibition of blood clearance and hepatic uptake by both galactose receptor-blocking and Fc receptor-blocking agents. A blocking dose of ASOR reduced the hepatic uptake at 30 min from 75 to 49%, and heat-aggregated gamma globulin reduced it from 75 to 39%, which suggests that these heavy complexes were removed from the circulation by receptors both for the immunoglobulin and for the antigen. Cell separation studies and autoradiographs confirmed that those complexes cleared primarily by galactose-mediated mechanism were within hepatocytes, and those cleared by Fc receptors were within the nonparenchymal cells of the liver. It seems probable, therefore, the some antigen-antibody complexes may be removed from the circulation via receptors not only for immunoglobulin but also for antigen.
OBSERVATIONS ON SOME CAUSES OF GALL STONE FORMATION
Authors: Peyton Rous, Philip D. McMaster, Douglas R. Drury
Journal: The Journal of Experimental Medicine (1924)

Gall stones frequently form in dogs intubated for the collection of bile under sterile conditions, in the absence of stasis and of gall bladder influence. The stones consist almost entirely of two substances—calcium carbonate and calcium bilirubinate—and they are remarkably uniform in character, as would follow from the limiting conditions of their development. They are not the result of bile loss, for similar ones may be recovered from the wall of glass tubes interpolated in ducts with intestinal connection undisturbed. The study of them has brought out evidence on the general problem of cholelithiasis. Some factors in their causation and that of gall stones as a class will be considered in succeeding papers.
Lactose malabsorption in Greek adults: correlation of small bowel transit time with the severity of lactose intolerance.
Authors: S Ladas, J Papanikos, G Arapakis
Journal: Gut (1982)

Using breath hydrogen analysis after 139 mmol (50 g) oral lactose load, we investigated the prevalence of lactose malabsorption in 200 Greek adults and examined the relationship between symptoms and small bowel transit time. One hundred and fifty subjects had increased breath hydrogen concentrations (greater than 20 ppm) after the lactose load. In these individuals peak breath hydrogen concentration was inversely related to small bowel transit time (r = 0.63, 6 = 6.854, p less than 0.001) and the severity of symptoms decreased with increasing small bowel transit time. Lactose malabsorbers with diarrhoea during the lactose tolerance test had a small bowel transit time of 51 +/- 22 minutes (x +/- SD; n = 90) which was significantly shorter than the small bowel transit time of patients with colicky pain, flatulence, and abdominal distension (74 +/- 30, n = 53; p less than 0.001) and both groups had significantly shorter small bowel transit time than that of asymptomatic malabsorbers (115 +/- 21 n:7; p less than 0.001). When the oral lactose load was reduced to 33 mmol (12 g), the small bowel transit time increased five-fold and the overall incidence of diarrhoea and/or symptoms decreased dramatically. These results indicate that the prevalence of lactase deficiency in Greece may be as high as 75% and suggest that symptom production in lactose malabsorbers is brought about by the rapid passage down the small intestine of the malabsorbed lactose.
Matrix Metalloproteinase 12, Asthma, and COPD
Authors: Guy G. Brusselle
Journal: New England Journal of Medicine (2009)

Asthma and chronic obstructive pulmonary disease (COPD) are obstructive airway diseases that involve chronic inflammation of the lower respiratory tract. They differ from each other in the pattern of inflammation, their immunologic mechanisms, the extent of reversibility of airflow limitation, and their inciting agents (allergens in the case of asthma and cigarette smoke in the case of COPD). Additional differences in diagnostic workup, treatment, and monitoring have warranted the development and implementation of separate guidelines for the diagnosis and management of these conditions. However, evidence is accumulating that asthma and COPD share common pathogenetic pathways. In particular, genetic studies investigating . . .
Metformin Impairs Vascular Endothelial Recovery After Stent Placement in the Setting of Locally Eluted Mammalian Target of Rapamycin Inhibitors Via S6 Kinase-Dependent Inhibition of Cell Proliferation
Authors: Anwer Habib, Vinit Karmali, Rohini Polavarapu, Hirokuni Akahori, Masataka Nakano, Saami Yazdani, Fumiyuki Otsuka, Kim Pachura, Talina Davis, Jagat Narula, Frank D. Kolodgie, Renu Virmani, Aloke V. Finn
Journal: Journal of the American College of Cardiology (2013)
CORONARY DISEASE AMONG SOLDIERS
Authors: Louis H. Sigler
Journal: JAMA (1953)

ABSTRACT To the Editor:— The interesting report by Enos, Holmes, and Beyer (Coronary Disease Among United States Soldiers Killed in Action in Korea, J. A. M. A.152:1090 [July 18] 1953) calls for comment. On its face value it is very alarming to find that, in 300 autopsies of young soldiers killed in action or in accidents who showed no clinical evidence of coronary disease during life, 77.3% had some gross evidence of coronary arteriosclerosis on postmortem examination. The average age was given as 22.1 years. The authors' statements leave us with the impression that upward of 77% of the youth in our country have coronary disease; this would, of course, be a frightening state. If we look over the few figures presented, however, we find that the ages were apparently obtained in only 200 cases, the youngest being 18 years and the oldest 48 years, with an average of
TCT-681 Long Term Outcomes Of Simple And Complex Coronary Bifurcation Lesions (CBL) Treated With Drug Eluting Stents (DES)
Authors: Leonard Ngunga, Po Kee Cheung, Shantu Bundhoo, Neil Brass, Benjamin Tyrrell, Raymond Leung, Micha Dorsch, William Hui
Journal: Journal of the American College of Cardiology (2012)
Aspiration of Gastric Contents in the Operative Period
Authors: Leroy D. Vandam
Journal: New England Journal of Medicine (1965)

ALTHOUGH expected to be increasingly rare, death and a considerable morbidity still follow the aspiration of gastric contents into the lungs in the anesthetic period. The exact rate of occurrence cannot be ascertained, for the accident is not officially reportable except perhaps to obstetric mortality commissions. Every physician probably will recall at least 1 such death in his practice. It is urgent, therefore, to call attention to the problem as being to a large extent preventable, and to narrate the anesthetic experience so far as it may pertain to other fields of medicine. Aspiration occurs in the comatose patient, in . . .
Steady-State Serum Amiodarone Concentrations: Relationships with Antiarrhythmic Efficacy and Toxicity
Authors: HESCHl H. ROTMENSCH
Journal: Annals of Internal Medicine (1984)

The relationship of apparent steady-state serum concentrations of amiodarone and its metabolite, desethylamiodarone, to therapeutic and toxic effects was assessed in 127 patients who had treatment-resistant ventricular or supraventricular arrhythmias or were intolerant to other agents. After at least 2 months (mean, 9.8) of treatment with daily maintenance doses of 200 to 600 mg, arrhythmias were effectively suppressed in 78% of patients. Arrhythmias recurred in 47% of patients with serum amiodarone concentrations of less than 1.0 mg/L, whereas only 14% of patients with higher concentrations had recurrences (p less than 0.005). Side effects, most of them mild, occurred in 57%; only 9 patients required discontinuation of drug therapy. The risk of developing adverse reactions was related to serum amiodarone concentrations (p less than 0.0001). Adverse reactions were common in patients with serum values exceeding 2.5 mg/L, although pulmonary complications did occur at lower concentrations. Monitoring serum amiodarone concentrations may differentiate failure of drug therapy from suboptimal dosing and reduce the incidence of concentration-related side effects.
Physician Referral—the AMA View
Authors: James S. Todd
Journal: JAMA (1989)

REPRESENTATIVE Fortney Stark (D, Calif) has introduced HR 939 (HR 5198 in the 100th Congress), a bill that would prohibit, in most cases, Medicare payment for services provided by any entity in which the referring physician or an immediate family member of the referring physician has an ownership interest. The legislation is based on the premise that a physician with an ownership interest in a facility will be less likely to exercise independent judgment in making referrals and that the physician may tend to overutilize the facility. Several steps have already been taken to address these possible professional conflicts. Under the Medicare Catastrophic Coverage Act of 1988 (Public Law No. 100-360), Medicare payment for services by a provider of home intravenous therapy services is prohibited when a referral is made by a physician with an ownership interest in the provider of intravenous therapy. Public Law No. 100-360 also required the