tbuckley/cabot-search huggingface dataset:
(2) Lichen verrucosus et reticularis of Kaposi (porokeratosis striata of Nekam)
Authors: D.M. MacDonald, D.I. Williams
Journal: British Journal of Dermatology (1974)

Journal Article (2) Lichen verrucosus et reticularis of Kaposi (porokeratosis striata of Nekam) Get access D.M. MacDonald, D.M. MacDonald King's College Hospital, London Search for other works by this author on: Oxford Academic Google Scholar D.I. Williams D.I. Williams King's College Hospital, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 91, Issue s10, 1 July 1974, Pages 39–40, https://doi.org/10.1111/j.1365-2133.1974.tb12505.x Published: 01 July 1974
THE RELATIONS OF THE PHYSICIAN TO PUBLIC HEALTH
Authors: HUGH S. CUMMING
Journal: JAMA (1927)

I have been asked as Surgeon General of the federal Public Health Service and as representing the official health organizations of the country to discuss "The Relations of the Physician to Public Health." It is needless to say that any views I may present are only my own personal impressions, which may perhaps be of value because of the opportunities that have been afforded me by my official position during the past seven years and through a service of thirty-three years in different regions of our country to hear the opinions not only of public health officials but also of nonofficial workers, medical men in private practice, and the public in whose welfare we are all equally concerned. As a matter of fact there is probably no unanimity of opinion throughout the profession; and, indeed, there must be so many varying factors, both personal and environmental, throughout the country which
Thrombosis in Connection with Serum Lipidic Changes in the Rat
Authors: Serge Renaud, Claude Allard
Journal: Circulation Research (1962)

Addition of either propylthiouracil or cholic acid to a natural diet (Purina Laboratory Chow) enriched in certain lipids resulted in hypercholesteremia and hyperlipemia of about the same amplitude. However, only cholic acid could induce a high incidence of thrombosis and cardiac infarct and a regular decrease in the percentage of serum alphalipoproteins with an electrophoretic pattern similar to that found in essential hyperlipemia or in certain nephrotic syndromes associated with thrombosis. In the rat, the thrombi, located in the arterioles and the capillaries of the heart and other organs, presented a histological picture that resembled thrombotic-thrombocytopenic-purpura rather than coronary disease. This thrombotic phenomenon was preceded by an acute increase in serum cholesterol and total lipids and was accompanied by the production of a large quantity of macrophages, with a foamy appearance, in the lung and the spleen. If propylthiouracil was added to this thrombogenic diet, the survival time of the animals was considerably shortened and the percentage of iufarcts reduced, but in this case, thrombosis was mainly located in the ventricles and the aorta. Under these experimental conditions, both of the hypercholesterolemic agents being used, lipidic infiltration of the vessels was detected but no tissular reaction that could result in atheromatous plaques.
<i>Mycobacterium tuberculosis</i>Growth Control by Lung Macrophages and CD8 Cells from Patient Contacts
Authors: Claudia Carranza, Esmeralda Juárez, Martha Torres, Jerrold J. Ellner, Eduardo Sada, Stephan K. Schwander
Journal: American Journal of Respiratory and Critical Care Medicine (2005)

Rationale: Healthy household contacts (HHCs) of patients with active pulmonary tuberculosis are exposed aerogenically to Mycobacterium tuberculosis (Mtb), thus permitting the study of protective local immunity.Objectives: To assess alveolar macrophage (AM) and autologous blood CD4 and CD8 T-cell–mediated Mtb growth control in HHCs and healthy, unexposed community control subjects (CCs).Methods: AMs were infected with Mtb strains H37Ra and H37Rv at multiplicities of infection 0.1 and 1. Mtb colony-forming units were evaluated on Days 1, 4, and 7.Main Results: CD8 T cells from HHCs in 1:1 cocultures with AMs significantly (p < 0.05) increased Mtb growth control by AMs. In CCs, no detectable contribution of CD8 T cells to Mtb growth control was observed. CD4 T cells did not increase Mtb growth control in HHCs or in CCs. IFN-γ, nitric oxide, and tumor necrosis factor were determined as potential mediators of Mtb growth control in AMs and AM/CD8 and AM/CD4 cocultures. IFN-γ production in AM/CD4 was twofold higher than that in AM/CD8 cocultures in both HHCs and CCs (p < 0.05). Nitric oxide production from AMs of HHCs increased on Days 4 and 7 and was undetectable in AMs from CCs. IFN-γ and nitric acid concentrations and Mtb growth control were not correlated. Tumor necrosis factor levels were significantly increased in AM/CD8 cocultures from HHCs compared with AM/CD8 cocultures from CCs (p < 0.05).Conclusion: Aerogenic exposure to Mtb in HHCs leads to expansion of Mtb–specific effector CD8 T cells that limit Mtb growth in autologous AMs.
Reflex modulation of lymphatic pumping in sheep.
Authors: N G McHale, T H Adair
Journal: Circulation Research (1989)

Lymphatic pumping activity was examined in halothane-anesthetized sheep. A doubly cannulated preparation of the mesenteric lymph duct was "isolated" from lymph input, other than that from a constant pressure reservoir of artificial lymph attached to its inflow cannula, but had its blood supply and innervation intact. A cerebral ischemic response, evoked by injection of 2 ml air into the common carotid artery, increased both mean arterial pressure and fluid propulsion by the lymphatic. The latter rose from a control value of 45 microliters/min to a peak of 74 microliters/min. When 10(-4) M phentolamine was introduced into the lymphatic lumen, there was a transient increase followed by a sustained fall in lymph pumping. Repetition of the air injection while phentolamine was present in the duct lumen produced no increase in lymph pumping. In adrenalectomized animals, resting lymph propulsion by the mesenteric duct was depressed, and the response to air injection was attenuated but remained significantly greater than control. These results suggest that reflex activation of the sympathetic nervous system can increase lymph propulsion and that this may be augmented by the release of circulating catecholamines.
45 Continued virologic and biochemical improvement through 96 weeks of entecavir treatment in HBeAg(−) chronic hepatitis B patients (study ETV-027)
Authors: D. Shouval, U.S. Akarca, G. Hatzis, G. Kitis, C.L. Lai, H. Cheinquer, T.T. Chang, R. Zink, J. Zhu, H. Brett-Smith
Journal: Journal of Hepatology (2006)
Abstract 2017: Development of a novel 3D tri-culture system in an in vitro non-small cell lung cancer (NSCLC) model
Authors: Arno Amann, Marit Zwierzina, Julia M. Huber, Gabriele Gamerith, Mario Bitsche, Elisabeth J. Pechriggl, Wolfgang Hilbe, Heinz Zwierzina
Journal: Cancer Research (2014)

Abstract Introduction: Different molecular processes lead to metastatic spread and the occurrence of tumor cell resistance to therapeutic interventions. Among them, the stromal compartment of tumors plays a key role. We describe the development of our 3D co-culture to a novel tri-culture model, using non-small cell lung cancer (NSCLC) cell lines in combination with a lung fibroblast and two different endothelial cell lines in a hanging drop technology. Methods: 96-well hanging drop microtiter plates (InSphero AG, Zürich, Switzerland) were applied for the production of 3D mono-, co- and tri-cultures including the human lung cancer cell lines A549 or Colo699 alone or in combination with a human lung fibroblast cell line (SV-80) and either the human umbilical vein endothelial cell line (HUVEC) or the human lung microvascular endothelial cell line (HMVEC-L). In addition, to conventional histology (H&amp;E, PAS) tumor fibroblast spheroid aggregation was displayed immunohistochemically (IHC) by protein expression of e-cadherin, vimentin, Ki67, CD31 and α-smooth muscle actin (α-SMA). Viability of each cell compartment of the microtissue was determined by a modified AnnexinV/Propidium Iodide staining for flow cytometry. Results: Endothelial cells aggregated either in small colonies with Colo699 or as single cells mainly in the stromal compartment of A540 microtissues. Simultaneously an up-regulation of vimentin and a downregulation of E-Cadherin was observed in co- and tri-cultures compared to monocultures. Furthermore, Ki67 expression increased significantly from mono- to co- and tri-cultures in both cancer cell lines, indicating a high metabolic activity. In addition, a morphological alteration of A549 tumor cells resembling “signet ring cells” was observed for the first time in both endothelial tri-cultures with a significantly increased glycoprotein expression demonstrated by a Periodic acid-Schiff (PAS) stain. Conclusion: We demonstrate that our method is a promising tool for the generation of multicellular tumor microtissues and reflects in vivo conditions closer than traditional 2D cell culture. Furthermore, it represents an appropriate alternative method to investigate endothelial cell interactions with tumor and stromal cells. Citation Format: Arno Amann, Marit Zwierzina, Julia M. Huber, Gabriele Gamerith, Mario Bitsche, Elisabeth J. Pechriggl, Wolfgang Hilbe, Heinz Zwierzina. Development of a novel 3D tri-culture system in an in vitro non-small cell lung cancer (NSCLC) model. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2017. doi:10.1158/1538-7445.AM2014-2017
Sildenafil and vardenafil, types 5 and 6 phosphodiesterase inhibitors, induce caspase-dependent apoptosis of B-chronic lymphocytic leukemia cells
Authors: Marika Sarfati, Véronique Mateo, Sylvie Baudet, Manuel Rubio, Christine Fernandez, Fréderic Davi, Jacques-Louis Binet, Jozo Delic, Hélène Merle-Béral
Journal: Blood (2002)
A Preliminary Note on an Epidemic of Paralysis in Children: (One Hundred and Twenty Cases)
Authors: A. Macphail
Journal: BMJ (1894)

CHILDREN. [K4z 12333 discomfort after meals."She further states that the severe headaches which she had been so constantly troubled with had disappeared.The spasmodic jerking of the limbs, from whichl sEe also suffered very frequently, had also gone.The walking powers had been practically quite regained.She can now walk at least two miles without stick or cratch, and with comfort.
Nitroblue tetrazolium test in psoriatic arthritis, rheumatoid arthritis, and osteoarthrosis.
Authors: J.R Lambert, M Roberts, V Wright
Journal: Annals of the Rheumatic Diseases (1978)

Nitroblue tetrazolium test scores were obtained in 43 patients with psoriatic arthritis, 32 patients with rheumatoid arthritis, and 16 patients with osteoarthrosis. The mean score in all groups was similar and was higher than previously reported in patients awaiting heart surgery or with noninfective dermatoses. The test is not thought to be helpful in differentiating psoriatic arthritis from rheumatoid arthritis, and its usefulness in the diagnosis of septic arthritis superimposed on other forms of arthropathy is limited.
The Mendoza Line and In-Training Examination Scores
Authors: John D. Cantwell
Journal: Annals of Internal Medicine (1993)

Letters15 September 1993The Mendoza Line and In-Training Examination ScoresJohn D. Cantwell, MDJohn D. Cantwell, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-6-199309150-00038 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Mario Mendoza, a Major League infielder from 1974 to 1982, played in 686 games, came to bat 1337 times, and had a career batting average of.215. As team physician for the Atlanta Braves, I learned that Major League players, when reviewing the weekly rankings, would look for the name Mendoza and would strive to keep their batting average above his minimum standardthe origin of the so-called Mendoza Line.For 5 years, I have tried to establish a Mendoza Line on the internal medicine in-training examination. Of 10 residents who were above the 50th percentile during their third ...REFERENCE1. Grossman RS, Fincher RM, Layne RD, et al. Validity of the in-training examination for predicting American Board of Internal Medicine Certifying Examination Scores. J Gen Intern Med. 1992; 7:63-7. Google Scholar Author, Article, and Disclosure InformationAuthors: John D. Cantwell, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCorrelations Between the USMLE Step Examinations, American College of Physicians In-Training Examination, and ABIM Internal Medicine Certification ExaminationAssociations Between United States Medical Licensing Examination (USMLE) and Internal Medicine In-Training Examination (IM-ITE) ScoresFactors Associated with Medical Knowledge Acquisition During Internal Medicine Residency 15 September 1993Volume 119, Issue 6Page: 541KeywordsBatsGames ePublished: 15 August 2000 Issue Published: 15 September 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Genetic analysis of a severe case of Netherton syndrome and application for prenatal testing
Authors: F.B. Muller, I. Hausser, D. Berg, C. Casper, R. Maiwald, A. Jung, H. Jung, B.P. Korge
Journal: British Journal of Dermatology (2002)

Summary Netherton syndrome (NS) is a rare autosomal recessive disease with variable expression. It is defined by a triad of symptoms: congenital ichthyosiform erythroderma, trichorrhexis invaginata and atopy. Recently, genetic linkage has been established to the SPINK5 gene locus on chromosome 5q32 encoding the serine protease inhibitor LEKTI. In this study, we present a recurrent homozygous mononucleotide deletion (153delT) resulting in a severe case of NS exhibiting exfoliative erythroderma with lethal outcome at the age of 4 months and its application in prenatal testing in a subsequent pregnancy of the mother.
Rapid Resolution of Massive Pulmonary Embolism Due to Streptokinase Therapy: Documented by Ventilation/Perfusion Imaging
Authors: JILL E. LANGER, MICHAEL G. VELCHIK
Journal: Clinical Nuclear Medicine (1988)

A case of massive pulmonary embolism is presented, with dramatic complete resolution within 36 hours due to anticoagulant and lytic therapy, documented by perfusion scintigraphy.
Effect of chemically modified IL-13 short interfering RNA on development of airway hyperresponsiveness in mice
Authors: Tricia N. Lively, Karl Kossen, Annette Balhorn, Toshiyuki Koya, Shawn Zinnen, Katsuyuki Takeda, Joseph J. Lucas, Barry Polisky, Ivan M. Richards, Erwin W. Gelfand
Journal: Journal of Allergy and Clinical Immunology (2008)

BackgroundRNA interference is an endogenous cellular mechanism in which short interfering RNAs (siRNAs) direct the sequence specific degradation of a target mRNA. siRNAs can be synthesized with chemical modifications to increase stability and reduce double-stranded RNA–induced immune responses without affecting their ability to elicit degradation of target mRNA.ObjectivesThis study examined the use of chemically modified siRNAs in a mouse model of allergen-induced airway hyperresponsiveness.MethodsChemically modified siRNAs were designed and screened in a cell-based reporter assay. The most potent siRNAs were then screened in bone marrow–derived mast cells to demonstrate efficacy in primary cells.ResultsA candidate siRNA was formulated and administered to sensitized mice just before airway challenge with allergen. Administration of the siRNA was shown to reduce airway resistance significantly in sensitized and challenged mice by 60%, whereas a control siRNA had no effect.ConclusionThese data demonstrate the effectiveness of introducing targeted siRNAs to prevent induction of allergen-induced airway dysfunction and suggest potential therapeutic applications. RNA interference is an endogenous cellular mechanism in which short interfering RNAs (siRNAs) direct the sequence specific degradation of a target mRNA. siRNAs can be synthesized with chemical modifications to increase stability and reduce double-stranded RNA–induced immune responses without affecting their ability to elicit degradation of target mRNA. This study examined the use of chemically modified siRNAs in a mouse model of allergen-induced airway hyperresponsiveness. Chemically modified siRNAs were designed and screened in a cell-based reporter assay. The most potent siRNAs were then screened in bone marrow–derived mast cells to demonstrate efficacy in primary cells. A candidate siRNA was formulated and administered to sensitized mice just before airway challenge with allergen. Administration of the siRNA was shown to reduce airway resistance significantly in sensitized and challenged mice by 60%, whereas a control siRNA had no effect. These data demonstrate the effectiveness of introducing targeted siRNAs to prevent induction of allergen-induced airway dysfunction and suggest potential therapeutic applications.
Nitrogen Dioxide—The New "Yellow Peril"
Authors: G. A. Lillington
Journal: JAMA (1970)

Oxides of nitrogen are a by-product of combustion in a number of industrial processes and may be formed in agricultural procedures, such as the ensilage of corn. A major emitter is the automobile internal combustion engine, and oxides of nitrogen from this source are major components of smog. Colorless nitric oxide reacts with oxygen in the air to form yellow-brown nitrogen dioxide, a gas which in appropriate concentrations reduces visibility, reacts with hydrocarbons in photochemical smog to form ozone, and is toxic to plants and animals in its own right. The biological effects on the lungs from inhalation of nitrogen dioxide have been thoroughly studied in experimental animals.<sup>1,2</sup>Similar lesions occur in humans subjected to accidental exposures to the gas; these include acute hemorrhagic pneumonia, pulmonary edema, and bronchiolitis fibrosa obliterans. In this issue (p 1341), Tse and Bockman describe acute and chronic pulmonary disorders in firefighters after exposure
THE EFFECT OF EXCESS VITAMIN A ON THE EMBRYONIC RAT OESOPHAGUS IN CULTURE
Authors: Ilse Lasnitzki
Journal: The Journal of Experimental Medicine (1963)

The effect of excess vitamin A on the oesophageal epithelium of late foetal rats has been studied in organ culture. In explants kept in normal medium the epithelium is, at first, higher and the keratinisation increased as compared with the development of the organ in vivo. At the later stages of growth, the acceleration of keratinisation leads to an extreme thinning of the epithelium. Excess vitamin A completely inhibits keratinisation and induces a transformation of the cells lining the oesophageal lumen into mucin-secreting elements. In vitamin A-treated cultures the epithelium remains high throughout the whole period of cultivation. The amount of secretory matter and the height of the epithelium seem to depend on an adequate supply of oxygen and carbon dioxide to the cells.
BMP type I receptor inhibition reduces heterotopic ossification
Authors: Paul B Yu, Donna Y Deng, Carol S Lai, Charles C Hong, Gregory D Cuny, Mary L Bouxsein, Deborah W Hong, Patrick M McManus, Takenobu Katagiri, Chetana Sachidanandan, Nobuhiro Kamiya, Tomokazu Fukuda, Yuji Mishina, Randall T Peterson, Kenneth D Bloch
Journal: Nature Medicine (2008)
IMPROVEMENT IN SEVERE KIDNEY DYSFUNCTION AFTER IMPLANTATION OF CONTINUOUS-FLOW LEFT VENTRICULAR ASSIST DEVICES
Authors: Shikhar Saxena, John Um, Ioana Dumitru, Brock Cookman, Samantha Pilmaier, Timothy Ryan, Shannon Yannone, Michael Moulton, Brian Lowes, Eugenia Raichlin
Journal: Journal of the American College of Cardiology (2013)
Private medicine price war?
Authors: D. M Graham-Service
Journal: BMJ (1980)

had low toxicity and gave an overall response rate of 73%0.In the multicentre study in 153 patients there were no drug-related deaths.We conclude that intracavitary bleomycin is well tolerated and is effective as palliative treatment for malignant effusions, preventing the need for frequent aspiration of accumulated fluid.Because of its lack of haematological toxicity it may be used safely in the already leucopenic patient.
Plasma Lipids and Microangiopathy in Insulin-dependent Diabetes Mellitus
Authors: R H Eckel, E McLean, J J Albers, M C Cheung, E L Bierman
Journal: Diabetes Care (1981)

The relationship of plasma levels of high density lipoprotein (HDL) cholesterol, apolipoproteins A-I and A-II (the major apolipoproteins in HDL), low density lipoprotein (LDL) cholesterol, triglyceride, and glucose to microangiopathy was evaluated in 49 insulin-dependent diabetic subjects. Although the HDL cholesterol/LDL cholesterol ratio (a risk determinant for macroangiopathy) was lower in women with proteinuria, no other relationships between HDL cholesterol or the A apolipoproteins and renal microangiography were found. The only independent association between HDL and retinal microangiopathy was found in women, where an inverse correlation was found between the apo A-I/apo A-II ratio and the number of microaneurysms (rs = -0.561, P less than 0.05). Men showed strong relationships of glucose, triglyceride, cholesterol, and LDL cholesterol to renal microangiopathy whereas women, in general, had stronger correlations of these variables with retinal microangiopathy. Thus, several alterations in lipoprotein cholesterol distribution and HDL composition are associated with diabetic microangiopathy. In addition, differences between sexes suggest that previously undescribed hormonal factors may influence the severity of this process.
Duodenal ulceration--is endoscopic biopsy necessary?
Authors: M J Greenall, M H Gough, M G Kettlewell
Journal: BMJ (1981)

tackle the problem early rather than to wait until disabilities develop that will be hard to rectify.Overweight patients need long-term supervision.If the doctor is unable to provide this himself he should refer the patient to someone who can-perhaps a hospital-based slimming group.Remember that patients differ.Whenever a woman's maga- zine features a "Slimmer of the Year," who has lost (she says) 10 stones in six months, readers think that everyone should be able to attain this: they cannot.One or two pounds a week is a reasonable long-term rate of weight loss for most people.Very rapid weight loss involves loss of lean tissue, and this is disadvantageous for the overweight patient.
Reconstruction of the Burned Hand
Authors: Radford C. Tanzer
Journal: New England Journal of Medicine (1948)

RECONSTRUCTION of the burned hand starts at the time of the initial dressing. Intelligent treatment during the first month will effectively prepare the hand for later restorative procedures, whereas misguided handling may thwart all efforts to bring back full function.Early TreatmentIt is generally agreed that the immediate local treatment of a burned hand includes a minimal amount of débridement confined at most to the gentle removal of vesiculated epidermis and the application of a firm, even pressure dressing. The fingers should be packed individually, and the entire hand encased in a bulky, fluffed-gauze dressing retained by a snug . . .
2011 ACCF/AHA/HRS Focused Update on the Management of Patients With Atrial Fibrillation (Update on Dabigatran)
Authors: L. Samuel Wann, Anne B. Curtis, Kenneth A. Ellenbogen, N.A. Mark Estes, Michael D. Ezekowitz, Warren M. Jackman, Craig T. January, James E. Lowe, Richard L. Page, David J. Slotwiner, William G. Stevenson, Cynthia M. Tracy
Journal: Circulation (2011)
ABC of blood pressure measurements.
Authors: D Kerr
Journal: BMJ (1979)

article (29 September, p 751)-never "give a moment's thought to its precise definition" are perhaps wiser than they know.Disease is one of those words best not defined.The same is true of health.What could be more fatuous than the famous definition of health made years ago by the World Health Organisation: "Health is a state of complete physical, mental, and social wellbeing, and not merely the absence of disease and infirmity"?