tbuckley/cabot-search huggingface dataset:
New Treament for Eczema
Authors: B. A. Schwetz
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Aromatase Inhibitor Exemestane has Antiproliferative Effects on Human Mesothelioma Cells
Authors: Daniela Stoppoloni, Luisa Salvatori, Annamaria Biroccio, Carmen D'Angelo, Paola Muti, Alessandra Verdina, Ada Sacchi, Bruno Vincenzi, Alfonso Baldi, Rossella Galati
Journal: Journal of Thoracic Oncology (2011)
Grand River Valley Medical Association.
Authors: B. B. Godfrey
Journal: JAMA (1898)

Holland, Mich., March 28, 1898. <h3>To the Editor:</h3> —On page 739 of theJournal, March 26,1898, under the head of "Post-Graduate Lectures at Home," it is claimed Eastern medical societies have adopted a new plan by which they increase their membership and interest in the meetings. The Grand River Valley Medical Society of Michigan adopted this plan in 1894 when at their annual meeting Prof. J. H. Etheridge was invited to be with us and read a very instructive paper; since which time we have had such men as Professors Dock and McClintock of Ann Arbor, Professors Graves, Green, Boise and Griswold of Grand Rapids. We find our meetings are made very instructive by this plan and will continue it as long as we can procure volunteers for their expenses and entertainment. Will some Chicago men volunteer for our May and August meetings, which occur on the second Tuesdays of
Global Right Atrial Mapping of Human Atrial Flutter: The Presence of Posteromedial (Sinus Venosa Region) Functional Block and Double Potentials
Authors: Paul A. Friedman, David Luria, Alexis M. Fenton, Thomas M. Munger, Arshad Jahangir, Win K. Shen, Robert F. Rea, Marshall S. Stanton, Stephen C. Hammill, Douglas L. Packer
Journal: Circulation (2000)

Previous studies of atrial flutter have found linear block at the crista terminalis; this was thought to predispose the patient to the arrhythmia. More recent observations, however, have demonstrated crista conduction. We sought to characterize the posterior boundary of atrial flutter.Patients with counterclockwise flutter (n=20), clockwise flutter (n=3), or both (n=5) were studied using two 20-pole catheters. Biplane fluoroscopy determined catheter positions. During counterclockwise flutter, craniocaudal activation occurred along the entire lateral and posterior right atrial walls. Septal activation proceeded caudocranially. In all patients, a line of block was seen in the posteromedial (sinus venosa) right atrium; this was manifested by the presence of double potentials where the upward and downward activations collided. Anatomic location was confirmed by intracardiac echocardiography in 9 patients. In patients with clockwise flutter, the line of block and double potentials were seen in the same location during counterclockwise flutter, but the activation sequence around the line of block was reversed. Pacing near the site of double potentials during sinus rhythm excluded a fixed line of block, and premature atrial complexes demonstrated functional block with manifest double potentials. In 2 patients, posterior ectopy organized to subsequently initiate isthmus-dependent atrial flutter.(1) A functional line of block is seen at the posteromedial (sinus venosa region) right atrium during counterclockwise and clockwise atrial flutter. (2) All lateral wall right atrial activation can be uniform during flutter, without linear block or double potentials in the region of the crista terminalis. (3) Activation at the site of posteromedial right atrial functional block can organize to subsequently initiate isthmus-dependent atrial flutter.
Abstract OT3-2-02: The PREDICT Study (Prospective, Randomized Early Detection and Intervention after Breast Cancer-Treatment, for women at risk of lymphedema)
Authors: AG Taghian, MN Skolny, J O'Toole, CL Miller, LS Jammallo, MC Specht
Journal: Cancer Research (2012)

Abstract Introduction: It is well-documented that lymphedema is one of the most feared long-term side effects of breast cancer (BC) treatment. However, to date, a standardized approach for the quantification and treatment of breast cancer-related lymphedema (BCRL) has yet to be established. Aims: We propose a screening and intervention trial that will assess the efficacy of early detection and intervention for BCRL. Intervention comprises the use of compression garments for mild lymphedema and compression garments +/− nighttime bandaging for moderate lymphedema. Other factors to be evaluated include: symptom clusters, treatment adherence, fear avoidance behavior, quality of life (QOL), upper extremity function, and risk factors for BCRL. Eligibility Criteria: Women 18 years + with a confirmed BC diagnosis, no history of BC, no known metastatic or locally advanced disease, no history of primary lymphedema, sentinel lymph node biopsy or axillary lymph node dissection as part of definitive breast surgery. Study Design: A two-stage study which includes a Screening and an Intervention trial. The screening arm will evaluate arm volume change during and after BC treatment with target accrual of 8000. Patients will undergo measurements via perometry and complete the MGH Lymphedema Evaluation Following Treatment for Breast Cancer (LEFT-BC) Survey at each screening appointment to evaluate changes in functionality, upper extremity utilization (fear associated avoidance), and QOL. Screening visits will occur pre- and post - operatively, at the conclusion of chemotherapy and radiation therapy and every 3–7 months thereafter. Patients will become eligible for enrollment into the intervention trial if, during the course of screening, they develop a relative arm volume change (RVC) of ≥ 5% which persists at a verification measurement within 4–8 weeks. Eligible subjects are enrolled into one of two groups based on verification RVC: Group I – Mild Lymphedema (5–10% RVC) or Group II – Moderate Lymphedema (11–20% RVC). Subjects are then randomized within each group. Group I subjects are randomized to one of two arms: I-A – Observation, I-B – Compression, and Group II subjects are randomized to one of two arms: II-A – Compression, II-B – Compression + Night Compression Bandaging. Target accrual for the intervention trial is 336 subjects (Group I: 208, Group II: 128). Clinical Relevance: The results of this study will yield level I evidence on the effectiveness of early detection and intervention for BCRL. Findings may shape clinical practice in diagnosis and treatment, as well as provide insight regarding the risk factors, symptoms, upper extremity function, and quality of life (QOL) associated with BCRL. *Funding by awards R01CA139118 &amp; 3P5OCA089393, AGT Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr OT3-2-02.
Mite (<i>Der p 1, Der f 1</i>) and cat (<i>Fel d 1</i>) allergens in the homes of babies with a family history of allergy
Authors: A. K. M. Munir, R. Einarsson, N.‐I. M. Kjellman, B. Björkstén
Journal: Allergy (1993)

Carpet and floor dust samples were collected in four different seasons, from 39 Swedish homes of babies with a family history of allergy. House‐dust mite ( Der p 1, Der f 1 ) and cat ( Fel d 1 ) allergen contents were determined by mab ELISA, and the levels were related to various environmental factors. Both mite and cat antigens were detected in 94% of the samples and in all homes, but the levels were low ( Der p 1 , range 15 ng–1944 ng/g fine dust; Der f 1 , range 14 ng–264 ng/g of fine dust; Fel d 1 , range 16 ng–3120 ng/g fine dust). Mite‐allergen levels were significantly higher ( P &lt;0.001) in floor dust than in carpets, and D. pteronyssinus predominated. In contrast, the levels of cat antigen were significantly ( P &lt;0.05) higher in carpets than in floor dust. There was no clear relation between mite‐allergen levels and type of house, except that the higher values were found in homes with dampness problems. Cat‐allergen levels were higher than total mite‐allergen content, and the highest levels were found in homes with a cat ( P &lt;0.05). Rather high concentrations of cat allergen were also found in homes without a cat, which may explain why cat sensitization is so common in Sweden. As the prevalence of house‐dust mite sensitivity is increasing in Swedish children, and as the individual patient threshold for eliciting symptoms varies, we suggest that sensitization may possibly occur at a lower exposure level than generally accepted as risk level for sensitization (2 μg/g dust).
UK government advises tighter measures to reduce risk of CJD transmission during neurosurgery
Authors: S. Mayor
Journal: BMJ (2003)

An Audit Commission report published this week has found that most NHS trusts have serious flaws in how they collect and report data on waiting lists.Errors in reporting waiting lists were found in 19 of the 41 trusts investigated; system errors that could increase risk of reporting errors were found in 15 trusts; and three trusts deliberately misreported information on their waiting lists.Only three of 41 trusts were given the all clear.The report, part of a five year rolling programme of spot checks of trusts, was commissioned by the Department of Health in an attempt to reassure the public that published statistics on waiting lists are robust.
Just Say NO to Aspirin?
Authors: Joan Stephenson
Journal: JAMA (2001)

A nitric oxide (NO)–releasing form of aspirin shows promise in animal studies as a way to prevent scarring and reclogging of blood vessels after angioplasty, according to a team of researchers from Italy and the United States (Proc Natl Acad Sci U S A. 2001;98:2860-2864).
Selecting Asymptomatic Patients for Coronary Computed Tomography or Electrocardiographic Exercise Testing
Authors: Philip Greenland, J. Michael Gaziano
Journal: New England Journal of Medicine (2003)

A healthy 40-year-old man exercises regularly, uses no tobacco, and has no cardiac symptoms. His blood pressure is 120/80 mm Hg, his total cholesterol concentration is 180 mg per deciliter, his high-density lipoprotein cholesterol concentration is 50 mg per deciliter, his body-mass index is 24, his fasting blood glucose concentration is 95 mg per deciliter, and he has no family history of coronary disease. Should he be advised to undergo coronary computed tomography or electrocardiographic exercise testing so that the assessment of his coronary risk may be refined?
The Mortality of Doctors in Relation to Their Smoking Habits
Authors: R. Doll, A. B. Hill
Journal: BMJ (1954)

All these studies agree in showing that there are more heavy smokers and fewer non-smokers among patients with lung cancer than among patients with other diseases.With one excep- tion (the difference between the proportions of non- -smokers found by McConnell, Gordon, and Jones) these differences are large enough to be important.While, therefore, the various authors have all shown
AN ABDOMINAL WICK.Read in the Section of Obstetrics and Diseases of Women, at the Forty-second Annual Meeting of the American Medical Association, held at Washington, D. C., May 1891.
Authors: ROBT. T. MORRIS
Journal: JAMA (1891)

In my first sixty· three laparotomy cases, dependence had been placed upon a drainage tube that was so efficient, so ready at hand, and so simple in its workings that I thought it good enough to be patented. That drainage tube was the patient's intestine, running through the middle of the great lymph bag of the abdomen, and ready to abstract from the sac any collection of fluid that was enticing to microbes, and to set it out of doors where their fatal breath would be exhaled into valueless space as they fought for possession of the sports. Deliquescent salts passed through the alimentary canal or injected into my drainage tube by way of the anas had cleared the great lymph sac by osmosis so regularly and with such ease that any other sort of tube seemed to be a superfluity. But one day this fine drainage tube failed. The
The Familial Aggregation of Obstructive Sleep Apnea
Authors: Susan Redline, Peter V. Tishler, Tor D. Tosteson, John Williamson, Kenneth Kump, Ilene Browner, Veronica Ferrette, Patrick Krejci
Journal: American Journal of Respiratory and Critical Care Medicine (1995)

An inherited basis for sleep-disordered breathing (SDB) has been suggested by reports of families with multiple affected members and by a previous study of the familial aggregation of symptoms of SDB. In this study, we quantify and characterize the aggregation of SDB and assess the degree to which familial similarities may be independent of obesity. This was a genetic-epidemiologic study that assessed the distribution of SDB in families identified through a proband with diagnosed sleep apnea and among families in the same community with no relative with known sleep apnea. SDB was assessed with overnight inhome monitoring of airflow, oxygen saturation, chest wall impedance, heart rate, and body movement. Standardized questionnaires were used to assess symptoms, and weight, height, and neck circumference were measured directly. Intergenerational and intragenerational correlation coefficients and pairwise odds ratios (ORs) were calculated with adjustment for proband sampling. In toto, 561 members of 91 families were studied: (1) 47 subjects with laboratory-confirmed SDB (index probands), (2) 44 community control subjects, and (3) the spouses and relatives of 1 and 2. Of all 91 families, 32 (35%) had two or more members with SDB, 30 (33%) had one affected member, and 29 had no affected members. SDB was more prevalent in the relatives of index probands (21%) than among neighborhood control subjects (12%) (p = 0.02). After adjusting for age, sex, race, and obesity, the odds of SDB, defined on the basis of age-specific threshold values for the respiratory disturbance index (RDI), was 1.3 greater in subjects with one affected relative, and 2.3 greater in subjects with three affected members when compared with subjects without affected family members. Intergenerational and intragenerational coefficients, describing the similarities in RDI levels among family members, were each 0.21 (p < 0.005), and they were not reduced significantly with adjustment for obesity. These results suggest that SDB significantly aggregates within families and that risk increases progressively with increasing numbers of affected relatives. The familial aggregation of SDB is not explained entirely by familial similarities in body mass index (BMI) or neck circumference, suggesting the importance of other familial factors in increasing susceptibility to the disorder.
Warming lignocaine to reduce pain associated with injection.
Authors: J. A. Davidson, S. J. Boom
Journal: BMJ (1992)

OBJECTIVE--To investigate the effect of warming lignocaine on the pain associated with subcutaneous injection. DESIGN--Double blind, randomised, crossover study. SETTING--Hospital clinic. SUBJECTS--40 healthy volunteers. INTERVENTIONS--Subcutaneous injection with 1 ml of 1% lignocaine at 20 degrees C and 1 ml of 1% lignocaine at 37 degrees C. MAIN OUTCOME MEASURES--Pain assessed by linear analogue pain scores and subjects9 comparison of pain on injection. RESULTS--25 subjects (89%; 95% confidence interval 72% to 98%) thought that lignocaine at 20 degrees C was more painful and 3 (11%; 2% to 28%) thought that lignocaine at 37 degrees C was more painful (p &lt; 0.0001); 12 subjects did not express a difference. Median pain score for injection at 20 degrees C was 11.00 and at 37 degrees C was 3.25 (p &lt; 0.001). Median difference was 8.25 (4.00 to 13.50). CONCLUSIONS--The simple procedure of warming to 37 degrees C reduced the pain associated with subcutaneous injection of lignocaine.
Biopsy Neutrophilia, Neutrophil Chemokine and Receptor Gene Expression in Severe Exacerbations of Chronic Obstructive Pulmonary Disease
Authors: Yusheng Qiu, Jie Zhu, Venkata Bandi, Robert L. Atmar, Keith Hattotuwa, Kay K. Guntupalli, Peter K. Jeffery
Journal: American Journal of Respiratory and Critical Care Medicine (2003)

We have applied immunohistology and in situ hybridization to bronchial biopsies of patients with chronic obstructive pulmonary disease (COPD) to examine neutrophil recruitment and to determine neutrophil chemoattractant and CXC receptor (CXCR) 1 and CXCR2 gene expression associated with acute severe exacerbations. Cells were counted in endobronchial biopsies of (1) patients with COPD intubated for exacerbations (E-COPD; n = 15), (2) those with COPD in a stable phase of their disease (S-COPD; n = 7), and (3) nonsmoker surgical control subjects intubated for a nonrespiratory surgical procedure (n = 15). In comparison with the nonrespiratory surgical procedure and S-COPD groups, neutrophilia and gene expression for epithelial-derived neutrophil attractant-78 (CXCL5), interleukin-8 (CXCL8), CXCR1, and CXCR2 were each upregulated in the E-COPD group (p < 0.01); compared with the S-COPD group, by 97-, 6-, 6-, 3-, and 7-fold, respectively (p < 0.01). In E-COPD, there was a significant positive association between the number of neutrophils and CXCR2 mRNA–positive cells (r = 0.79; p < 0.01) but not between the number of neutrophils and CXCR1 mRNA–positive cells. At the time of sampling of the mucosa, there was no association between neutrophil number and either the length of intubation or viral infection. Thus, in COPD, in addition to CXCL8 and CXCR1, CXCL5 and CXCR2 appear to play important roles in the airway neutrophilia characteristic of severe exacerbations.
Case of Hydrophobia
Authors: N. C. Dobson
Journal: BMJ (1872)

of warm water) were introduced into the sixth interspace, in the axil- lary line, and, immediately after the first ounce or two had passed, the respirations became less hurried.One pint and a half of clear straw- coloured serous fluid were withdrawn.There was complete re-expan- sion of the compressed lung, and, on listening, the respiratory mur- murs were distinctly heard.Shortly after the operation, the little patient lay comfortable on the sound side, slept, and passed a good night.March 4.-He expressed himself as quite well ; pulse I 20.Vesicular breathing was well heard.There were no signs of any re-accumulation of fluid.Marclh 6.-The respirations were quiet; there was no difficulty or pain during respiration, or when turning from side to side; pulse Ioo.In the evening he had two slight rigors, shortly followed by several watery stools.March Ii.-He continued to improve; pulse go.He had no pain or uneasiness, and felt stronger.His appetite was good.March i8.-During the last four days he had been going about the house without any difficulty or accelerated breathing.March 22.-There was no shrinking of the walls of the chest, or evi- dence of the reaccumulation of fluid ; the respirations were normal.This case has been recorded as an example of the beneficial effects of the early performance of paracentesis thoracis in cases of acute pleurisy with effusion.From the time of the operation there has not been one unfavourable symptom, showing.theavoidance of the formation of ad- hesive bands, with the gradual contraction of the affected side, and diminished power of expansion, occasionally accompanied with a partly carnified lung.Up to the present time (September), he is in excellent health. HEADACHES IN CHILDREN.+
Newcastle GP charged with murder
Authors: C. Dyer
Journal: BMJ (1998)

A GP who admitted giving lethal doses of painkillers to terminally ill patients has been charged with the murder of an elderly patient.

David Moor, aged 51, has been summonsed to appear before Newcastle upon Tyne magistrates on 30 July. He was arrested last July and given bail pending the outcome of drugs tests on the body of George Liddell, a former ambulanceman who died of cancer aged 85.

Northumbria Police launched an inquiry after the Newcastle coroner, Leonard Coyle, …
EXAMINATION OF THE GYNECOLOGIC PATIENT FOR DIAGNOSIS.
Authors: AUGUSTIN H. GOELET
Journal: JAMA (1907)

Examination for the purpose of making a gynecologic diagnosis comprises, or should comprise, more than is ordinarily realized by many who undertake it. As a rule, it is too casual to be thorough or accurate, and in consequence associated conditions, often of relative importance, are overlooked and disregarded. In presenting this subject for your consideration, I have no idea that I shall offer anything new, nor yet anything with which you are not already familiar. My object is chiefly to direct attention to some salient features of these examinations that are sometimes disregarded and to emphasize the importance of certain apparently unimportant details that are essential for accurate and complete diagnosis of these conditions. <h3>HISTORY OF THE PATIENT.</h3> The history<sup>1</sup>and manner of taking it is of much importance. It may be brief, but should be complete and thorough, the essential points bearing on the condition being brought out
Münchhausen to Munchausen
Authors: HEINRICH G. BRUGSCH
Journal: Annals of Internal Medicine (1977)

Comments1 June 1977Münchhausen to MunchausenHEINRICH G. BRUGSCH, M.D., F.A.C.P.HEINRICH G. BRUGSCH, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-6-833_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Reading Dr. Allegra's and colleagues' comments in "Munchausen as Physician and Patient" (Ann Intern Med 85:262-263 1976) I recall vividly a female physician impersonator who, when I was a student of medicine in Berlin, fooled even persons of such capacity as the venerable Prof. Karl Bonhoeffer. However, Bonhoeffer, normally somewhat haughty and stern, had enough sense of humor to present the "Doctor" on grand rounds after he discovered her true background.The middle-aged woman applied for a staff position at Bonhoeffer's University hospital, showing considerable knowledge of psychiatry. She had told him in an interview that she... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Prudential Insurance Company of America Prudential Office Boston, MA 02199 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1977Volume 86, Issue 6Page: 833-834 Issue Published: 1 June 1977 PDF downloadLoading ...