tbuckley/cabot-search huggingface dataset:
Recurrent Human Granulocytic Ehrlichiosis and Lyme Disease
Authors: James R. Johnson
Journal: Annals of Internal Medicine (1999)

Letters15 June 1999Recurrent Human Granulocytic Ehrlichiosis and Lyme DiseaseJames R. Johnson, MDJames R. Johnson, MDVeterans Affairs Medical Center; Minneapolis, MN 55417 (Johnson)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-12-199906150-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their recent report of a patient who developed reinfection with the agent of human granulocytic ehrlichiosis (1), Horowitz and colleagues provided (without discussion) evidence of another interesting phenomenon in the same patient—reinfection with the agent of Lyme disease.The described patient had no detectable serologic response to Borrelia burgdorferi after her initial episode of erythema migrans; this may have been an instance of the much-discussed but little- documented abortive effect of early antimicrobial therapy on the development of an antibody response to the Lyme spirochete. The patient later developed clinical evidence of reinfection, now with seroconversion ...References1. Horowitz HW, Aguero-Rosenfeld M, Dumler SJ, McKenna DF, Hsieh T, Wu J, et al . Reinfection with the agent of human granulocytic ehrlichiosis. Ann Intern Med. 1998;129:461-3. LinkGoogle Scholar2. Guidelines for laboratory evaluation in the diagnosis of Lyme disease. American College of Physicians. Ann Intern Med. 1997; 127:1106-8. Google Scholar3. Rahn DW, Malawista SE. Lyme disease: recommendations for diagnosis and treatment. Ann Intern Med. 1991;114:472-81. LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Veterans Affairs Medical Center; Minneapolis, MN 55417 (Johnson) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoReinfection with the Agent of Human Granulocytic Ehrlichiosis Harold W. Horowitz , Maria Aguero-Rosenfeld , J. Stephen Dumler , Donna F. McKenna , Tze-chen Hsieh , Joseph Wu , Ira Schwartz , and Gary P. Wormser Recurrent Human Granulocytic Ehrlichiosis and Lyme Disease Harold W. Horowitz , Maria E. Aguero-Rosenfeld , and Gary P. Wormser Metrics 15 June 1999Volume 130, Issue 12Page: 1029KeywordsAntibody productionAntimicrobialsBorrelia burgdorferiEhrlichiosisEnzyme linked immunosorbent assayErythemaHumoral immunityLyme diseaseSpirochetesWestern blot Issue Published: 15 June 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Primidone in the Treatment of the Long QT Syndrome: QT Shortening and Ventricular Arrhythmia Suppression
Authors: DENNIS L. DeSILVEY
Journal: Annals of Internal Medicine (1980)

We studied a family with the long QT syndrome. The initial case was in a patient who presented with seizures, ventricular fibrillation, and syncope. After a trial of conventional modalities of treatment including left stellate ganglionectomy, primidone (Mysoline) therapy was initiated. This drug has been successful in suppressing ventricular arrhythmias and shortening the QT interval over a 2-year follow-up period. Two additional family members with QT prolongation have been treated with primidone. During an 8-month follow-up, electrocardiographic and Holter recordings showed shortening of the QT interval.
Abstract A60: NK cell activation and cytotoxicity can be enhanced with chemotherapy in a murine model of glioblastoma.
Authors: Serena Pellegatta, Gabriele Cantini, Sara Pessina, Gaetano Finocchiaro
Journal: Cancer Research (2013)

Abstract Chemotherapy is currently regarded as a potential ally for cancer immunotherapy. Several anticancer agents, including classical chemotherapeutic compounds, are able to enforce tumor specific immune responses either by inducing the immunogenic death of tumor cells or by modulating key cells for immune suppression or activation. To determine whether Temozolomide (TMZ), the standard chemotherapeutic agent for glioblastoma and malignant gliomas, could induce tumor immunogenicity, we treated murine GL261 cells with 50 and 150 microM TMZ in vitro for 2, 8 and 20 hours. Flow cytometry showed that the NKG2D ligand, involved in NKG2D-mediated NK cell recognition of tumor cells, was highly expressed by TMZ-treated GL261, whereas GL261 treated with vehicle showed only a weak expression (P &amp;lt; 0.01). B7-H3, an inhibitory molecule for NK cells, significantly decreased in TMZ-treated GL261 cells (P &amp;lt; 0.01). TGF-beta1 and TGF-beta2 concentrations in the supernatant from GL261 treated with TMZ significantly decreased, as shown by ELISA (from 23.2 ± 2.5 and 478.4 ± 19.3 in vehicle to 13.2 ± 2.2 and 283.8 ± 25.9 in TMZ-treated cells, respectively, P &amp;lt; 0.0001). We therefore studied the effects of TMZ on anti-tumor NK cell response by treating mice 7 days after intracranial implantation of GL261 gliomas with intraperitoneal injections of TMZ (5mg/kg) or vehicle (control mice) for 5 days. Five mice were sacrificed 20 hours after treatment on days 1-5: brain, spleen and blood were harvested and analyzed by flow cytometry. Trafficking of NKp46+ NK1.1+ CD3- NK cells in blood but not in spleen and their homing ability into the brain significantly increased in TMZ-treated compared to control mice after the second administration of TMZ (7.5 ± 1.4 vs 2.3 ± 1.2, P = 0.001; 10.9 ± 0.4 vs. 3.9 ± 0.6, P = 0.005, respectively). Notably TMZ led to an enrichment of CD11bhigh CD27high NK cells, the most potent effector cells. To verify NK anti-glioma activity, NK1.1 positive cells were isolated from blood and brain of treated and control mice using magnetic separation and incubated with GL261 cells. NK cell cytotoxicity from TMZ-treated mice was significantly higher than that NK cells from control mice. These results support the contention that chemotherapy may induce enhancement of NK cell response and open new opportunities to design novel combined therapies reversing the immune suppressive role of glioblastoma and unmasking the therapeutic potential of NK responses. Citation Format: Serena Pellegatta, Gabriele Cantini, Sara Pessina, Gaetano Finocchiaro. NK cell activation and cytotoxicity can be enhanced with chemotherapy in a murine model of glioblastoma. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances; Dec 2-5, 2012; Miami, FL. Philadelphia (PA): AACR; Cancer Res 2013;73(1 Suppl):Abstract nr A60.
Clinical Gastroenterology CD-ROM version
Authors: C J Tibbs
Journal: Gut (1995)

How good is it?With over 200 contributors, the one thing that the reviewer can state with absolute certainty is that it's uneven, and in its 5th edition it shows the Forth Bridge- type characteristics that anything under con- stant repair develops.Some of the initial overview chapters on signs and symptoms show their age, with mannered prose remind- ing that this book was first published nearly 50 years ago.Another section boldly states in footnote 'many of the references pertaining to this section are not recent ... most findings of investigators during [1960s and 1970s] are still valid' -which really is editor-speak for 'this section should have been revised'.Some areas of 'small-print' gastroenterology -and actually, week to week, that is what people use reference textbooks for -seem to have got rather brief treatment: you won't find all you want to know about Menetrier's for example.However, each item that one can find to criticise is balanced by a state of the art chapter of superlative quality.If the trainee
Abstract 3145: Effect of Gout and Allopurinol Use on Heart Failure Outcomes
Authors: George Thanassoulis, Hugues Richard, James M Brophy, Louise Pilote
Journal: Circulation (2009)

Background: Hyperuricemia is associated with reduced survival among heart failure (HF) patients but the effect of gout on HF outcomes is not known. A recent randomized trial suggested that allopuri...
Premortem assessment of myocardial area at risk with the use of intracoronary technetium macroaggregated albumin and gated nuclear imaging.
Authors: A J Feiring, P Bruch, T S Husayni, P T Kirchner, M L Marcus
Journal: Circulation (1986)

The purpose of this study was to develop a clinically applicable system for quantifying premortem myocardial area at risk. Coronary artery occlusion was performed in 18 closed-chest dogs (11 left anterior descending and seven circumflex). 99mTc (15 mCi)-labeled macroaggregated albumin was then injected through an angiographic catheter into the left main coronary artery. Gated nuclear images were obtained in the left anterior oblique view in dogs with left anterior descending occlusions and in right anterior oblique views in dogs with circumflex artery occlusions. The corresponding end-diastolic images were analyzed. The percent area at risk was determined as the planimetric ratio between the hypoperfused area and that of the total left ventricular myocardium. At the completion of the study the heart was excised and the autoradiographic area at risk for the left ventricle was determined. The theoretic advantage of the use of gated acquisition for determination of area at risk over the use of nongated acquisition was assessed. For each study a time-integrated nongated image was produced by summating all frames of the gated study. The area at risk on this composite image was analyzed in the same manner as for the gated study and compared with the postmortem area at risk. Studies in five control dogs in which concomitant left atrial and intracoronary injection of different radioactive-labeled macroaggregates were used revealed no false-positive defects and similar and relatively homogenous radionuclide distribution. Postmortem autoradiographic area at risk ranged from 3.8% to 36.3% of the left ventricular mass. End-diastolic areas at risk in vivo correlated well with those determined by the postmortem autoradiographic method (r = .95, y = 0.86x + 2.7). The regression equations relating interobserver and intraobserver variance for analysis of the end-diastolic image areas at risk were small (r = .98, y = 1.06x - 0.66 and r = .96, y = 1.06x - 0.50, respectively). The interobserver and intraobserver differences for determinations of autoradiographic area at risk were represented by r = .99, y = 1.04x - 0.54 and r = .95, y = 0.88x + 2.79. Finally, comparison of the area at risk in vivo for the nongated image with the postmortem area at risk yielded a correlation of r = .79, y = 0.80x - 2.2. Nongated imaging was less sensitive and accurate than gated imaging and resulted in three false-negative studies, as well as a poorer correlation with results of postmortem autoradiography.(ABSTRACT TRUNCATED AT 400 WORDS)
Myocardial reactive hyperaemia responses in the dog after beta receptor block with propranolol
Authors: T. J. Pauly, N. Bittar
Journal: Cardiovascular Research (1971)

Myocardial reactive hyperaemia responses in the dog were shown to decline after administration of propranolol. This appears to be due to the action of propranolol on cardiac contractility and its ability to block adrenergic vasodilator receptors as well as the myocardial stimulating effect of catecholamines.
Deprived of health
Authors: M. Bartley
Journal: BMJ (1995)

Panorama's programme on health inequalities was well timed to follow close behind the Rowntree report on growing social inequality. Unfortunately, the importance of the programme in terms of policy debate was not matched by the quality of the technical presentation. Health Minister Gerald Malone was somehow induced to say that material deprivation “is clearly a factor” contributing to social differences in life expectancy, needing to be set alongside lifestyle, and that the government has “a clear policy to look at social variations in health and address our policies towards them.” It is quite an achievement to have placed this on the record. However, it seems unlikely that the minister watched a preview of the evidence presented and decided the game was up. As is often the case, the presentation of the “human interest” …
Distribution of glucose transporters in membrane fractions isolated from human adipose cells. Relation to cell size.
Authors: E Karnieli, A Barzilai, R Rafaeloff, M Armoni
Journal: Journal of Clinical Investigation (1986)

We examined insulin's effects on glucose transport and on subcellular transporter distribution in isolated human omental adipocytes of various sizes. Insulin stimulated 3-O-methylglucose transport by twofold in small cells, while a smaller and insignificant effect was measured in large cells. In the small cells, basal concentrations of glucose transporters were 2.9 and 17.2 pmol/mg membrane protein in the plasma and the low density microsomal membranes, respectively. Increasing cell size was associated with a 50% decrease in the concentration of transporters in each fraction, with no change in their total number per cell. Insulin stimulated the translocation of transporters from the intracellular pool to the plasma membranes, irrespective of cell size. Thus, insulin resistance at the postreceptor level, observed in human obesity, may be associated with a relative depletion of total transporters per cell together with a reduction in their intrinsic activity at the plasma membrane level.
Cardiology in the Young
Authors: Jonathan D. Eldredge
Journal: JAMA (1992)

Congenital heart malformations probably afflict up to 20 per 1000 population. The MEDLINE database's current file (1989—March 1992) lists 9416 references to English-language articles related to cardiovascular diseases in children.  Public attention appears to parallel growing medical concerns about pediatric heart conditions. In April 1991, for example, the US Senate authorized establishing new National Institutes of Health centers to study cardiovascular diseases in the young. Such interest in pediatric cardiology seems to have prompted publication of this new journal, Cardiology in the Young .  More than 235 cardiology periodicals exist, but, surprisingly, only one other English-language journal focuses on this specific population. With its solid reputation, 12 years of service, and coverage by major biomedical indexing services, one might suppose that Pediatric Cardiology could present serious competition to this newcomer. On the other hand, Pediatric Cardiology published only 160 of the 9146 pediatric cardiology articles found in the current MEDLINE file.
Mycosis fungoides and chronic lymphocytic leukaemia - composite T-cell and B-cell lymphomas presenting in the skin
Authors: P.R. Hull, A. Saxena
Journal: British Journal of Dermatology (2000)

Composite lymphomas involving cutaneous B-cell and T-cell lymphomas are very uncommon. We report here the unique circumstance of a patient with mycosis fungoides (primary cutaneous T-cell lymphoma) who later developed chronic lymphocytic leukaemia (B-cell lymphoproliferation, B-CLL), which presented in the skin (leukaemia cutis) as a composite lymphoma affecting an earlobe. The presence of both lymphoproliferative disorders was confirmed with immunophenotyping and the finding of both immunoglobulin gene rearrangements and T-cell receptor gene rearrangements in the ear and the same T-cell receptor gene rearrangement in a plaque lesion of mycosis fungoides on the arm.
COMPARISON OF BARE-METAL AND DRUG-ELUTING STENTS IN LARGE CORONARY ARTERIES: A REPORT FROM THE NATIONAL HEART, LUNG, AND BLOOD INSTITUTE DYNAMIC REGISTRY
Authors: Chi Yuen Chan, Helen Vlachos, Faith Selzer, Suresh Mulukutla, Oscar Marroquin, J. Abbott, Elizabeth Holper, David Williams
Journal: Journal of the American College of Cardiology (2012)
THE PRESENT POSITION OF SILICOSIS IN INDUSTRY IN BRITAIN
Authors: E. L. Middleton
Journal: BMJ (1929)

THD. JBRw 485 hIosp)ital for German measles, the true diagnosis being reached only when the eruption did not clear up in the tinmse ulsuial for measles.Clhancres of a terminal phalanx sile Usually diag,nosed as whitlow until a rash appears.The worst erlor of this kinid I ever saw was in a medical officer who was lookinig after syphilis cases during the war.He allow-ed his fiiger to be treated for whitlow, and his tonsils to be cauter ized for ulcers, and then went peacefully to ho(ispital for measles.It dawned on him that he lhad acci- dentally contracted syphilis, when the measles rash was succeeded l)y a pr-ofuse papular syphilide.Tlhe error of excluding syphilis may be made from the absence of any history of a primarv sore.A rather remark- able case of this kind was a nurse who pricked her finger in cleaning up after an operation.She dipped the finger in antiseptic, and no sore appeared, as I have known to hlappen after the application of an antiseptic in other cases.Ani axillairy adeniitis appeared on the side of the pricked linger, atdl it was diagnosed as tuberculous.Subsequently a genieral, rather painful adenopathy appeared, aind she was
Standardized patient encounters. A method for teaching and evaluation
Authors: M. A. Ainsworth
Journal: JAMA (1991)

The primary goal of medical education is to foster development of clinical competence in trainees at all levels. Variable clinical experience, inconsistent methods of instruction, and ambiguous evaluation criteria undermine this goal. Standardized patients, trained to consistently portray a wide variety of clinical cases, can help overcome many of these educational problems. This article describes the development and application of standardized patients throughout medical training at The University of Texas Medical Branch, Galveston, in the freshman interviewing course, the second-year physical diagnosis course, third-year clerkships, a fourth-year final exercise, and residency training. Development of this program is discussed in the context of a broader literature in medical education, and investigation of variables affecting standardized patient and student performance is reported. Future directions for use of standardized patients in monitoring and promoting the development of clinical competence are discussed.
PSYCHIATRIC APPROACHES TO EXPIRATION OF SENTENCE MEN
Authors: DAVID H. DABNEY
Journal: American Journal of Psychiatry (1963)

This paper gives the psychiatric findings of 100 expiration of sentence offenders released from the Lorton Reformatory (D. C.) between Apr. 1, 1961 and Mar. 31, 1962. The Bureau of Rehabilitation, engaged the author as consultant in Apr. 1961, to study, evaluate and offer psychotherapy where needed. It was made clear to these men that their participation was entirely on a voluntary basis. Impressions of these men were derived from their classification records. They were then seen by the author in both individual and group meetings before leaving Lorton. The observations of each man in the individual and group meetings before leaving Lorton correlated favorably with the original impression rendered for each, from the classification records. They were all asked to come to see the author after release. The 100 men fell into 6 groups: 1. Sociopathic Personality (33%); 2. Inadequate Personality (20%); 3. Passive-Aggressive Personality (15%); 4. Schizophrenic Reactions in Remission (12%); 5. Mental Deficiency, Acquired (12%); and 6. Chronic Brain Syndromes (3%). All had committed crimes against both person and property. The mental defectives as well as the chronic brain syndromes seemed to have lacked reasoning and judgment, indices of intelligence. The borderline schizophrenics had associated breaks from reality, involving each one's particular delusional system in their acts; the passive-aggressives, resistance; the inadequate, compensation; and the sociopathic, projection. Three significant conclusions were derived. 1. The element of fixation is a major factor in each expiration of sentence offender, before incarceration, during and after; 2. The approach to crime prevention should include consideration of the psychodynamics of the individual expiration of sentence man; and 3. The concept of identity is ever-present in each expiration of sentence man, although distorted, which can and must be utilized in salvaging the individual, reducing further criminal activity on his part and interposing realistic social values in his outlook on life after prison. Many correctional and related authorities feel that this group of men, in general, are difficult to communicate with and relate to, while some feel ambivalent. This paper is an attempt to offer some courses in future efforts to widen the channels of communication and relationship with this group of men along psychiatric lines, including the descriptive, dynamic and eclectic approaches.
Homeopaths will be allowed to practise modern medicine in Maharashtra after one year pharmacology course
Authors: S. Bagcchi
Journal: BMJ (2014)

A decision by the government of Maharashtra to allow homeopaths to practise modern (allopathic) medicine after a one year bridge course in pharmacology has angered doctors throughout India. 

Six medical associations—the Indian Medical Association, the Maharashtra Association of Resident Doctors, the Maharashtra Medical Council, the Association of Medical Consultants, the General Physicians Association, and the Maharashtra State Medical Teachers Association—have joined together to challenge the decision, which they are calling “illegal” and “politically motivated,” and they may take the issue to the High …
Uncertainty and sampling error
Authors: D. G. Altman, J. M. Bland
Journal: BMJ (2014)

Medical research is conducted to help to reduce uncertainty. For example, randomised controlled trials aim to answer questions relating to treatment choices for a particular group of patients. Rarely, however, does a single study remove uncertainty. There are two reasons for this: sampling error and other (non-sampling) sources of uncertainty. The word “error” comes from a Latin root meaning “to wander,” and we use it in its statistical sense of meaning variation from the average, not “mistake.” Sampling error arises because any sample may not behave quite the same as the larger population from which it was drawn. Non-sampling error arises from the many ways a research study may deviate from addressing the question that the researcher wants to answer.

Sampling error is very much the concern of the statistician, who imagines that the group of people in the study is just one of the many possible samples from the population of interest. Despite it being widely condemned,1 the dominant way of …
SPINAL ANESTHESIA IN PROSTATECTOMY
Authors: ARTHUR L. CHUTE
Journal: JAMA (1922)

In the enucleation of a prostate, the anesthetic requirements differ from those met in surgery in general. It has been shown by many observers that the urinary back pressure that we find in a considerable proportion of prostatic cases renders the kidneys especially susceptible to the irritating effects of ether. I believe it was the late John C. Munro who showed, some years ago, the irritating effect that the inhalation of ether had on the supposedly normal kidney. Observations were made on the urine of a series of patients, before and after taking ether. In a considerable proportion of cases, it was found that, after ether, the urine showed some albumin in cases in which the urine had previously shown none. This was accepted quite properly, I believe, as an indication that ether frequently irritated the normal kidney. Therefore, one of our first requirements for an anesthetic in prostatectomy is
Does Triggered Activity Have a Role in the Genesis of Cardiac Arrhythmias?
Authors: MICHAEL R. ROSEN
Journal: Annals of Internal Medicine (1981)

Whether triggered activity plays a role in the genesis of cardiac arrhythmias is considered in this review. The characteristics of triggered activity are compared with those of automaticity and re-entry at the cellular electrophysiologic level, and these observations then are related to cardiac arrhythmias. We stress, however, that the relation between triggered activity and clinical arrhythmias still is largely speculative and that further experimental and clinical study is needed before the presence (or absence) of a role for triggered activity is verified.