tbuckley/cabot-search huggingface dataset:
Evaluation of Left Ventricular Function in Kawasaki Disease Using Equilibrium Multigated Blood Pooling Ventriculography
Authors: CHIA-HUNG KAO, KAI-SHENG HSIEH, SHYH-JEN WANG, SHIN-HWA YEH
Journal: Clinical Nuclear Medicine (1995)

Twenty-eight children ranging in age from 1-6 years (11 girls, 17 boys) with Kawasaki disease and, for comparison, 30 normal children ranging in age from 1-8 years (8 girls, 22 boys) without any cardiovascular disease were included in this study. The left ventricular functions of the children were evaluated by equilibrium multigated blood pooling ventriculography (EMBPV), which was performed after in vivo labeling of red blood cells using 10 mCi Tc-99m pertechnetate. Scintigraphy was performed using a digital gamma camera with the aid of an electrocardiogram gate. The left ventricular functions were determined by Fourier analysis of the time-activity curve in the left ventricles. The parameters of the left ventricular functions included: 1) systolic phase—[a] ejection fraction (EF), [b] ejection time (ET), [c] peak ejection rate (PER), and [d] first 1/3 ejection rate mean (1&sol;3ERM), and 2) diastolic phase—[a] peak filling rate (PFR), [b] fast filling fraction (FFF), [c] time to peak filling rate (TPFR), and [d] first 1/3 filling rate mean (1&sol;3FRM). The results showed that no significant differences existed between the two groups in any parameter of the left ventricular function. The authors suggest that the left ventricular functions in children with Kawasaki disease are not apparently impaired. The results were proven by the presentation of the EMBPV in this study.
THE PHYSIOLOGIC ACTION OF THE THYROID GLAND.
Authors: HUBERT RICHARDSON
Journal: JAMA (1897)

The very different results obtained by the administration of the thyroid gland, or its extracts, and the reports of its success in so many forms of disease, require some further explanation, and I here give the results of a few observations made during the past six months on its possible physiologic action among the insane. In the paper read by Dr. C. G. Hill on the subject of thyroid feeding, an analysis of the urine made by Dr. Whitney is given, which shows that though the excretion of chlorids, phosphates, sulphates and to a lesser extent urea are slightly increased, the total solids are decreased, pointing to the non-elimination or non-formation of the more toxic products of metabolism, with the possible exception of the ethereal sulphates. Dr. Haig showed by experimentation on himself that thyroid feeding produced a retention or possibly a reduced production of uric acid. Dr. Perry, in
Characteristics and Long-Term Outcomes of Percutaneous Revascularization of Unprotected Left Main Coronary Artery Stenosis in the United States
Authors: J. Matthew Brennan, David Dai, Manesh R. Patel, Sunil V. Rao, Ehrin J. Armstrong, John C. Messenger, Jeptha P. Curtis, Kendrick A. Shunk, Kevin J. Anstrom, Eric L. Eisenstein, William S. Weintraub, Eric D. Peterson, Pamela S. Douglas, William B. Hillegass
Journal: Journal of the American College of Cardiology (2012)
MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo
Authors: Lorena Fontan, Chenghua Yang, Venkataraman Kabaleeswaran, Laurent Volpon, Michael J. Osborne, Elena Beltran, Monica Garcia, Leandro Cerchietti, Rita Shaknovich, Shao Ning Yang, Fang Fang, Randy D. Gascoyne, Jose Angel Martinez-Climent, J. Fraser Glickman, Katherine Borden, Hao Wu, Ari Melnick
Journal: Cancer Cell (2012)
Varicella Zoster and Staphylococcal Toxic Shock Syndrome in a Young Man
Authors: Jay A. Jacobson
Journal: JAMA (1983)

STAPHYLOCOCCAL toxic shock syndrome (TSS), which was first reported by Todd et al,<sup>1</sup>who described the disease in children, subsequently received widespread clinical and public recognition as an epidemic that affected many menstruating women.<sup>2,3</sup> Intensive epidemiologic and laboratory investigation linked TSS to the use of tampons and to the presence of specific toxin-producing staphylococci in the vagina.<sup>4-7</sup>After the withdrawal of certain tampon products from the marketplace and, possibly, other changes in catamenial use, the incidence of TSS in menstruating women has apparently declined.<sup>8</sup>The syndrome, however, and variants of it have been increasingly recognized in other populations. Toxic shock syndrome has been described in postpartum and postmenopausal women, postoperative patients of both sexes, and prepubertal children.<sup>1,4,5,9</sup>We recently cared for a patient whose case illustrates the growing number of circumstances that may predispose to or be associated with TSS. <h3>Report of a Case</h3> A
Randomized Controlled Trial of the Role of Positron Emission Tomography in the Management of Stage I and II Non-Small-Cell Lung Cancer
Authors: Rosalie C. Viney, Michael J. Boyer, Madeleine T. King, Patricia M. Kenny, Christine A. Pollicino, Jocelyn M. McLean, Brian C. McCaughan, Michael J. Fulham
Journal: Journal of Clinical Oncology (2004)

Purpose Positron emission tomography (PET) is a costly new technology with potential to improve preoperative evaluation for patients with non–small-cell lung cancer (NSCLC). There is increasing pressure for PET to be included in standard diagnostic work-up before decisions about surgical management of NSCLC. The resource implications of its widespread use in staging NSCLC are significant. Methods A randomized controlled trial was conducted to investigate the impact of PET on clinical management and surgical outcomes for patients with stage I-II NSCLC. The primary hypothesis was that PET would reduce the proportion of patients with stage I-II NSCLC who underwent thoracotomy by at least 10% through identification of patients with inoperable disease. Results One hundred eighty-four patients with stage I-II NSCLC were recruited and randomly assigned; 92% had stage I disease. Following exclusion of one ineligible patient, 92 patients were assigned to no PET and 91 to PET. Compared with conventional staging, PET upstaged 22 patients, confirmed staging in 61 and staged two patients as benign. Stage IV disease was rarely detected (two patients). PET led to further investigation or a change in clinical management in 13% of patients and provided information that could have affected management in a further 13% of patients. There was no significant difference between the trial arms in the number of thoracotomies avoided (P = .2). Conclusion For patients who are carefully and appropriately staged as having stage I-II disease, PET provides potential for more appropriate stage-specific therapy but may not lead to a significant reduction in the number of thoracotomies avoided.
Facilities for Exfoliative Cytology
Authors: R. R. Charlwood
Journal: BMJ (1964)

MEDICALcertificate on this evidence alone, but this sign of itself indicates a considerable degree of incoordination.One cannot help prejudging the issue as the question invariably arises, " Is this man likely to be found guilty on this evidence ?" The very posing of this question inevitably results in the issue of many more negative certificates than would otherwise be the case.The time has surely come when we must do away with the clinical examination of the accused and substitute a bloodor urinealcohol level above which it would be an offence to be in charge of a motor vehicle.-I am, etc., Swansea, Glam.
Lipid peroxides and atherosclerosis.
Authors: M. D. Stringer, P. G. Gorog, A. Freeman, V. V. Kakkar
Journal: BMJ (1989)

Plasma lipid peroxide concentrations were measured in 100 patients with occlusive arterial disease proved angiographically (50 patients with ischaemic heart disease, 50 with peripheral arterial disease) and compared with values in 75 control patients with no clinical evidence of atherosclerosis. Lipid peroxide concentrations were significantly higher in patients both with ischaemic heart disease (median 4.37 mumol/l (interquartile range 3.85-5.75 mumol/l); p less than 0.001) and with peripheral arterial disease (median 4.37 mumol/l (3.88-5.21 mumol/l); p less than 0.001) than in controls (median 3.65 mumol/l (interquartile range 3.29-3.89 mumol/l). Overall there was a significant but weak correlation between plasma lipid peroxide and plasma triglyceride concentrations (rs = 0.25; p less than 0.001) but not between plasma lipid peroxide and plasma total cholesterol concentrations. Furthermore, hypertension, obesity, diabetes, smoking, positive family history, and intake of beta blockers and thiazide diuretics were not associated with significant differences in lipid peroxide values. This study provides clinical support to experimental data indicating that peroxidised lipids may be important in atherogenesis and its complications and also suggests that peroxidised lipids may provide an index of the severity of atherosclerosis.
Abstract 2863: RNase-L modulates the immune response to intestinal damage and ameliorates murine colitis and colitis-associated cancer.
Authors: Tiha M. Long, Arindam Chakrabarti, Heather Ezelle, Sarah Brennan-Laun, Jean-Pierre Raufman, Irina Polyakova, Robert Silverman, Bret Hassel
Journal: Cancer Research (2013)

Abstract The endoribonuclease RNase-L is a Type-I interferon (IFN)-regulated component of the innate immune response that functions in antiviral and antibacterial activities. Here we identify a protective role for RNase-L in the inflammatory response to gastrointestinal (GI) injury and commensal bacteria. In a dextran sulphate sodium (DSS)-induced model of ulcerative colitis RNase-L-/- mice exhibited a more severe clinical score and increased mortality compared to wild type animals. The enhanced sensitivity to GI damage was accompanied by delayed leukocyte infiltration and reduced expression of the proinflammatory cytokines IFNβ, TNFα, IL-1β and IL-18 at early times post-DSS exposure. This impaired innate immune response corresponded with increased inflammation and a decreased capacity to recover from GI injury at later times. Consistent with the established role of inflammation as a risk factor for colorectal cancer, in a model of colitis-associated cancer DSS treated RNase-L-/- mice displayed an increased carcinogen-induced tumor burden and mortality. A potential mechanism by which RNase-L functions in the response to GI damage and commensal bacteria is via the production of RNA agonists of RIG-I-like receptors (RLRs), sensors of cytosolic pathogen-associated RNAs that initiate signaling to induce proinflammatory cytokines important to GI homeostasis. Indeed, we found that bacterial RNA triggers IFNβ induction in macrophages in an RNase-L-dependent manner. Together, these results support a model in which the protective role for RNase-L in experimental colitis and colitis-associated cancer occurs through RNase-L-dependent RLR signaling and IFNβ induction. Citation Format: Tiha M. Long, Arindam Chakrabarti, Heather Ezelle, Sarah Brennan-Laun, Jean-Pierre Raufman, Irina Polyakova, Robert Silverman, Bret Hassel. RNase-L modulates the immune response to intestinal damage and ameliorates murine colitis and colitis-associated cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2863. doi:10.1158/1538-7445.AM2013-2863
The Triad of Anotia, Facial Paralysis, and Cardiac Anomaly Not Due To Thalidomide
Authors: Fred Matthies
Journal: JAMA (1966)

ABSENCE OF EARS is a rare and striking developmental abnormality. Recently European researchers have reported several infants with anotia or microtia in conjunction with facial paralysis and cardiac anomaly. A history of thalidomide ingestion by the mother was noted in these instances. An infant was born with a similar combination of deformities, occurring where the possibility of thalidomide ingestion by the mother was extremely remote. <h3>Report of a Case</h3> A female infant was born on June 28, 1964, after 38 weeks gestation. She weighed 2.22 kg (4.89 lb) and was 44.45 cm (17.5 inches) long at birth. The Apgar score was 7; the placenta was not weighed nor were the cord vessels examined. The absence of both external ears was immediately apparent (Figure) and further examination revealed no auditory canals. A right facial paralysis and a systolic cardiac murmur were also noted. Results of laboratory studies, including an electroencephalogram, were
Guest Editorial: Biomarkers of Perfluorinated Chemicals and Birth Weight
Authors: David A. Savitz
Journal: Environmental Health Perspectives (2007)

has conducted a series of studies addressing causes of adverse pregnancy outcomes including preterm birth, miscarriage, and pregnancy complications.He is currently serving as a member of a science panel established to evaluate the potential health effects of PFOA and PFOS exposure in West Virginia and Ohio, with a particular focus on reproductive health and neurobehavioral development.
Heparin and Factitious Purpura
Authors: H. CHUL KIM
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 March 1982Heparin and Factitious PurpuraH. CHUL KIM, M.D., MARTIN KOSMIN, M.D.H. CHUL KIM, M.D.Search for more papers by this author, MARTIN KOSMIN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-3-377_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the brief report by Schmaier and associates (1) of factitious heparin administration. We report a similar case and describe another laboratory method for discerning surreptitious use of heparin, utilizing a synthetic substrate (Protopath, Dade Laboratories) (2) that shows therapeutic levels of heparin in the samples.A 25-year-old white female registered nurse was evaluated for extensive purpura in her lower extremities in May 1980. Findings on initial coagulation screening tests, including prothrombin time, activated partial thromboplastin time, thrombin time, and fibrinogen, were normal. Five months later, however, she was examined again because of recurrent...References1. SCHMAIERCARABELLODAYBARRY AJHW. Factitious heparin administration. Ann Intern Med. 1981;95:592-3. LinkGoogle Scholar2. MITCHELLGARGUILOHUSEBYLAWSONPOCHRONSEHUANES GRRDSJ. Assay for plasma heparin using a synthetic peptide substrate for thrombin: introduction of the fluorophore aminooispthalic acid, dimethyl ester. Throm Res. 1978;13:47-52. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Peter's Medical Center and CMDNJ-Rutgers New Brunswick, NJ 08903 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1982Volume 96, Issue 3Page: 377-377KeywordsFibrinogenHeparinNursesPartial thromboplastin timeProthrombin timeResearch laboratoriesThrombin Issue Published: 1 March 1982 PDF DownloadLoading ...
Pretransplant minimal residual disease level predicts clinical outcome in patients with acute myeloid leukemia receiving high-dose chemotherapy and autologous stem cell transplantation
Authors: A Venditti, L Maurillo, F Buccisano, G Del Poeta, C Mazzone, A Tamburini, M I Del Principe, M I Consalvo, P De Fabritiis, L Cudillo, A Picardi, A Franchi, F L Coco, S Amadori
Journal: Leukemia (2003)
Incidence et signification clinique des hyperfixations focales coliques de découverte fortuite en TEP-TDM. Étude rétrospective de 10 mois
Authors: E Billet, N Keromnes, PY Salaun, F Cholet, M Férec, J Jezequel, J Faycal, M Robaszkiewicz
Journal: Endoscopy (2011)

Introduction: Les hyperfixations focales coliques sont régulièrement mises en évidence de façon fortuite au décours d'une TEP-TDM réalisée en dehors de toute pathologie colique. La fréquence des lésions correspondantes est variable dans la littérature. Les objectifs de cette étude étaient de déterminer l'incidence et la signification clinique de ces hyperfixations afin d'en déduire des éléments d'aide à la décision d'une exploration colique.
Induction of classical transplantation tolerance in the adult.
Authors: S X Qin, S Cobbold, R Benjamin, H Waldmann
Journal: The Journal of Experimental Medicine (1989)

Transplantation tolerance across histoincompatibilities in multiple non-H-2 minors (B10.BR into CBA/Ca) and "minor" plus H-2D (B10.A into CBA/Ca) antigens has been achieved successfully by combined adult bone marrow transplantation and treatment with CD4 and CD8 mAbs. The tolerant state was confirmed by permanent acceptance of donor strain skin grafts, and in vitro unresponsiveness to donor cells. Tolerance was associated with partial donor chimerism to various degrees. Tolerance to minor transplantation antigens induced in this manner was restricted to recipient-type MHC. The possibility was raised that tolerance resulted, at least in part, from clonal anergy rather than deletion.
Psychotic Episodes and Postpsychotic Depression in Young Adults
Authors: FREDERICK S. HOEDEMAKER
Journal: American Journal of Psychiatry (1970)

While the depression that follows a psychotic episode in a late adolescent may be very painful to the patient, the therapist should view it as a good prognostic sign: the patient recognizes his psychic "bankruptcy" and is willing to do some needed therapeutic work. An intensive psychotherapeutic involvement at this crucial time may prevent a later intractable psychosis.
Cardiac Resynchronization Therapy Reduces Left Atrial Volume and the Risk of Atrial Tachyarrhythmias in MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy)
Authors: Andrew Brenyo, Mark S. Link, Alon Barsheshet, Arthur J. Moss, Wojciech Zareba, Paul J. Wang, Scott McNitt, David Huang, Elyse Foster, Mark Estes, Scott D. Solomon, Ilan Goldenberg
Journal: Journal of the American College of Cardiology (2011)
Impact of HIV infection and AIDS on prevalence of type 2 diabetes in South Africa in 2010
Authors: V. R Panz, B. I Joffe
Journal: BMJ (1999)

EDITOR—Many non-communicable diseases are set to increase dramatically during the 21st century. In particular, the prevalence of diabetes mellitus may double from 124 million people worldwide in 1997 to 220 million by 2010.1 Regions with the greatest potential increases are Asia and Africa—precisely the areas with the greatest potential increases in the prevalence of HIV infection and AIDS. The impact of HIV infection and AIDS on the diabetes epidemic is difficult to assess, but we have tried to estimate it for South Africa using population data …
Rearrangement and expression of the immunoglobulin μ-chain gene in human myeloid cells
Authors: Jing Huang, Xiaoping Sun, Xiaoting Gong, Zhiqiao He, Lei Chen, Xiaoyan Qiu, C Cameron Yin
Journal: Cellular and Molecular Immunology (2013)

Immunoglobulin (Ig), a characteristic marker of B cells, has been reported to be expressed in epithelial cells, with a suggested role in their growth and survival. We have previously reported that IgG heavy chain is expressed in acute myeloid leukemia (AML), but not in the monocytes or neutrophils from patients with non-hematopoietic neoplasms or healthy controls. In the present study, we assessed IgM heavy chain expression and repertoire in human myeloid cells. We detected VHμDJHμ rearrangement and expression in 7/7 AML cell lines, 7/14 primary myeloblasts from AML patients, and interestingly, 8/20 monocytes and 3/20 neutrophils from patients with non-hematopoietic neoplasms and healthy individuals. We also found evidence of somatic hypermutation of the variable (V) gene segments in AML-derived IgM gene rearrangements but not in IgM from monocytes or neutrophils from patients with non-hematopoietic neoplasms and healthy individuals. Furthermore, IgM VHμDJHμ gene rearrangements in AML cell lines, primary myeloblasts, and monocytes and neutrophils from patients with non-hematopoietic neoplasms showed a restricted V usage and repertoire, whereas the VHμDJHμ gene rearrangements in monocytes and neutrophils from healthy individuals displayed more diversity. Anti-human IgM inhibited cell proliferation, but did not induce apoptosis in AML cell lines. Our findings suggest that AML-derived IgM might be a novel AML-related molecule that is involved in leukemogenesis and AML progression and might serve as a useful molecular marker for designing targeted therapy and monitoring minimal residual disease.
A persistent headache
Authors: A. J. Dawson, C. Rowland-Hill, S. L. Atkin
Journal: BMJ (2010)

A 34 year old man was admitted to the medical admissions unit with a history of headache and vomiting. He had been experiencing neck pain for the preceding four months; his headache had developed gradually over this time but had worsened over the past two weeks. The headache was described as a “throbbing” sensation over the frontal area of the skull radiating to the neck, and the patient felt as if his scalp “was being ripped on and off.” The headache was not related to the time of day. He also described some pain over his left eye. He had a two week history of vomiting associated with the headache, but no photophobia. On further questioning, he had not noticed any change in his libido.

On examination the patient did not have a fever (temperature 36.8°C) and was haemodynamically stable (respiratory rate 15 breaths a minute, heart rate 85 beats a minute, blood pressure 125/65 mm Hg). Clinical examination of the neurological system determined papilloedema, and visual fields were noted to show a bitemporal hemianopia. Endocrine examination revealed reduced body hair; testes were not examined. All other system examinations were unremarkable.

Blood tests initially showed a haemoglobin concentration of 155 g/l, a white cell count of 12.0×109/l (neutrophils 10.1×109/l), a platelet count of 225×109/l, a urea concentration of 5.3 mmol/l, and a serum sodium concentration of 136 mmol/l, potassium concentration of 3.7 mmol/l, and bicarbonate concentration of 27 mmol/l.

Computed tomography of the head was performed, followed by magnetic resonance imaging (fig 1⇓).



A subsequent blood test showed a prolactin level of greater than 1 035 190 pmol/l (reference range 207-725), an 8 am cortisol concentration of 75 nmol/l, a thyroid stimulating hormone concentration of 0.6 mIU/l (0.5-4.7), a free thyroxine level of 11 …