tbuckley/cabot-search huggingface dataset:
Proteins and the Theory of Colloidal Behavior.
Authors: Jacques Loeb
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Remission of Macroglobulinemia during Anastrozole Treatment for Breast Cancer
Authors: Crystal Chettle, Michael A. Baker
Journal: New England Journal of Medicine (2005)

transforming growth factor a in a total of 10 formalin-fixed, paraffin-embedded pulmonary adeno-carcinomas, 4 with mutant EGFR proteins and 6 without.The four EGFR alterations included the major mutation types: missense mutations within exon 18 (G719C) and exon 21 (L861Q) and deletions within exon 19 (delL747-P753insS and delL747-T751insS).All specimens containing these mutant receptors showed strong expression of both ligands in the tumor cells but not in the surrounding stromal cells (Fig. 1).Similar results were observed in the six cases with wild-type EGFR proteins, in agreement with prior reports. 4Thus, pulmonary adenocarcinomas with EGFR mutations are similar to more common forms of lung cancer, in which autocrine secretion of EGFR ligands by tumor cells stimulates the receptors.The exceptional response of tumors with mutant EGFR proteins to gefitinib most likely results from distinct downstream signaling from the receptor after the ligand binds. 5Our observations raise the possibility that mutations of EGFR arise within a pulmonary epithelial cell that is already secreting epidermal growth factor and transforming growth factor a, thus initiating a proliferative stimulus.
Patient feedback as a way to improve quality of care
Authors: R. J. Reeves, E. West
Journal: BMJ (2014)

We agree with Coulter and colleagues that patient experience data should be used more effectively, but introducing another NHS data collating/analysing body could be counterproductive if the implicit assumption is that all data are (more or less) equally valid.1 Poorly collected data detract from scientifically valid data. The recent proliferation of “rapid” patient feedback focuses attention on quick fixes at the expense of tackling …
Liver Scans in Evaluation of Lesions of the Diaphragm
Authors: ELCON D. LEVINSON, RICHARD P. SPENCER, DANIEL M. ROSWIG, JAMES SAYRE
Journal: Clinical Nuclear Medicine (1981)

Three patients had chest radiographs suggesting pathology associated with the right hemidiaphragm. The patients' histories included trauma in one case, recently diagnosed leukemia in a second, and Hodgkin's disease in the third. In all three cases, the Tc-99m-sulfur colloid liver scan provided a noninvasive identification of the nature of the diaphragmatic densities seen on the chest radiographs, thus affecting patient management.
CD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infection
Authors: Rodolfo Silva, Susan Moir, Lela Kardava, Karen Debell, Venkateswara R. Simhadri, Sara Ferrando-Martínez, Manuel Leal, José Peña, John E. Coligan, Francisco Borrego
Journal: Blood (2011)
Regulation of multidrug resistance 2 P-glycoprotein expression by bile salts in rats and in primary cultures of rat hepatocytes
Authors: Seema Gupta, Todd R. Stravitz, William M. Pandak, Michael Müller, Reno Z. Vlahcevic, Phillip B. Hylemon
Journal: Hepatology (2000)

Biliary phospholipid secretion is tightly coupled to the secretion of free cholesterol and bile salts. The secretion of phospholipids across the canalicular membrane of hepatocytes occurs via the multidrug resistance 2 (mdr2) P-glycoprotein (Pgp). The mechanism underlying the coupling of bile salt and phospholipid secretion has not been elucidated. The aims of this study were to determine the effects of bile acid structure on the expression of mdr2 in vitro and in vivo. Under optimal culture conditions, taurine-conjugated bile acids (50 μmol/L) increased mdr2 messenger RNA (mRNA) levels in the following order: taurocholate (TCA) (288 ± 36%, P &lt; .005) = taurodeoxycholate (TDCA) (276 ± 36%, P &lt; .025) &gt; taurochenodeoxycholate (TCDCA) (216 ± 34%, P &lt; .025) &gt; tauroursodeoxycholate (TUDCA) (175 ± 28%, P &lt; .05) of control levels. The increase in mdr2 mRNA levels by TCA was both time and concentration dependent. Cholate feeding to rats with intact enterohepatic circulation increased mdr2 transcriptional activity by 4-fold and protein mass by 1.9-fold. Chronic biliary diversion (CBD) decreased mdr2 mRNA levels to 66 ± 9% ( P &lt; .025) of sham-operated controls. Intraduodenal infusion of TCA for 48 hours in CBD rats caused a significant increase in mdr2 mRNA levels (224%) as compared with CBD controls. A diet high in cholesterol (4%) decreased mdr2 mRNA levels to 57% ± 2 ( P &lt; .001) of pair-fed controls. Squalestatin (1 μmol/L), an inhibitor of cholesterol biosynthesis, increased mdr2 mRNA levels by 8.8-fold ( P &lt; .005) in hepatocyte cultures after 24 hours. In conclusion, in the rat, bile acids up-regulated mdr2 transcriptional activity whereas cholesterol decreased mdr2 mRNA both in vitro and in vivo.
Long-Term Results After Systematic Off-Pump Coronary Artery Bypass Graft Surgery in 1000 Consecutive Patients
Authors: Ismail El-Hamamsy, Raymond Cartier, Philippe Demers, Denis Bouchard, Michel Pellerin
Journal: Circulation (2006)

Off-pump coronary artery bypass surgery (OPCAB) is currently used as an alternative to conventional "on-pump" surgery, but there are very little data available on long-term follow-up. The aim of this study was to review our long-term experience with the use of systematic OPCAB.1000 consecutive OPCAB surgeries were systematically performed between 1996 and 2004, representing 95% of all coronary revascularization during that same time frame, with a 97% complete follow-up. Average age of the patients was 64+/-10 years (778 men and 222 women). Seventy-three percent had triple-vessel disease. Operative 30-day mortality was 1.6%. Overall survival at 96 months was 74+/-3.5% and cardiac survival was 94+/-1.3%. By Cox regression analysis, age (odds ratio [OR], 1.07), congestive heart failure (CHF) (OR, 1.90), peripheral vascular disease (OR, 1.74), chronic renal insufficiency (OR, 2.04), previous myocardial infarction (MI) (OR, 1.60), and New York Heart Association functional class (OR, 1.60) were risk factors for long- term mortality. Survival free of any cardiac events (cardiac death, MI, unstable angina, heart failure, or reintervention) was 80+/-3.4%. Survival free of any type of reintervention alone was 90+/-3%. By Cox regression analysis, mitral regurgitation (OR, 2.3), peripheral vascular disease (OR, 2.1), and diffuse coronary disease (OR, 2.3) were significant predictors of recurrent cardiac events. Conversion to "on-pump" (OR, 14.3) was predictor of long-term need for repeat revascularization.In this series, systematic OPCAB surgery was shown to be an acceptable alternative to conventional "on-pump" coronary artery bypass graft for the treatment of coronary artery disease.
Development of liposomal formulations: From concept to clinical investigations
Authors: Yuchen Fan, Qiang Zhang
Journal: Asian Journal of Pharmaceutical Sciences (2013)

Liposome is one of the most successful drug delivery systems applying nanotechnology to potentiate the therapeutic efficacy and reduce toxicities of conventional medicines. Since the first doxorubicin-loaded liposome reached the market, numerous researches have been carried out to develop new liposomal formulations over the past decade and have given birth to a series of commercial products. Therapeutic agents, most of which are anti-cancer drugs, are encapsulated in the aqueous core or lipid bilayers of liposomes to improve their delivery to the targeted tissue. There are several liposomal formulations, such as EndoTAG-1 (paclitaxel-loaded cationic liposomes), Lipoplatin (cisplatin-loaded long circulating liposomes) and Stimuvax (a cancer vaccine), showing promising therapeutic value in clinical studies. Besides, new designs including environmentally sensitive liposomes, liposomal drug combinations and liposomal vaccines are now tested in clinical trials.
C-REACTIVE PROTEIN OVEREXPRESSION EXACERBATES PRESSURE OVERLOAD-INDUCED CARDIAC REMODELING THROUGH ENHANCED INFLAMMATORY RESPONSE AND OXIDATIVE STRESS
Authors: Toshiyuki Nagai, Toshihisa Anzai, Hidehiro Kaneko, Yoshinori Mano, Atsushi Anzai, Yuichiro Maekawa, Tsutomu Yoshikawa, Keiichi Fukuda
Journal: Journal of the American College of Cardiology (2011)
Needle in Heart
Authors: Harold R. Brodman
Journal: JAMA (1978)

To the Editor.—  In the LETTER TO THE EDITOR Unusual Foreign Body Pathway to the Heart (238:2016, 1977), correspondents McCormack and Knapper state that a review of the literature showed only one other case 1 of a sewing needle self-introduced into the chest. We reported a case of a self-inflicted sewing needle introduced into the myocardium in 1949, 2 and at that time we found an additional similar previous report. It is of interest that Berg's 3 case as well as ours showed evidence of pericarditis. It is regrettable that the current report omits electrocardiographic findings.
Medical Education in Colombia
Authors: GEORGE T. HARRELL
Journal: Annals of Internal Medicine (1978)

Abroad1 August 1978Medical Education in ColombiaGEORGE T. HARRELL, M.D., M.A.C.P.GEORGE T. HARRELL, M.D., M.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-2-283 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptColombia is an agricultural country whose chief export is coffee. From prehistoric times it has been known as a source of the finest emeralds. About 1500, the Spanish established a fortress and shipping base at Cartagena on the Caribbean coast. A 200-mile band of jungle and mountains separated this area culturally and economically from the rest of the country until very recently when a road, narrow gauge railroad, and especially air routes linked it with the politically and economically dominant central and western cities and valleys.Though universities have been in operation for more than 150 years, medical education has... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Timonium, Maryland Medical Sciences Emeritus The Milton S. Hershey Medical Center The Pennsylvania State University PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMedical Education in ColombiaALFREDO F. JACOME-ROCA, M.D. 1 August 1978Volume 89, Issue 2Page: 283-284KeywordsCoffeeMedical education Issue Published: 1 August 1978 PDF DownloadLoading ...
Rapid Dissemination of β-Lactamase–Producing, Aminoglycoside-Resistant<i>Enterococcus faecalis</i>among Patients and Staff on an Infant–Toddler Surgical Ward
Authors: Emily Rhinehart, Nancy E. Smith, Christine Wennersten, Eileen Gorss, Jonathan Freeman, George M. Eliopoulos, Robert C. Moellering, Donald A. Goldmann
Journal: New England Journal of Medicine (1990)

Original Article from The New England Journal of Medicine — Rapid Dissemination of β-Lactamase–Producing, Aminoglycoside-Resistant Enterococcus faecalis among Patients and Staff on an Infant–Toddler Surgical Ward
Recognition and Treatment of Posttraumatic Stress Disorder
Authors: Jonathan R. T. Davidson
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<i>RASSF1A</i>Polymorphism A133S Is Associated with Early Onset Breast Cancer in<i>BRCA1/2</i>Mutation Carriers
Authors: Boning Gao, Xian-Jin Xie, Chunxian Huang, David S. Shames, Tina T-L. Chen, Cheryl M. Lewis, Aihua Bian, Bifeng Zhang, Olufunmilayo I. Olopade, Judy E. Garber, David M. Euhus, Gail E. Tomlinson, John D. Minna
Journal: Cancer Research (2008)

Abstract The tumor suppressor gene RASSF1A regulates cell cycle progression, apoptosis, and microtubule stability and is inactivated by promoter methylation in ∼50% of breast cancers. It has been shown previously that the polymorphism A133S in RASSF1A reduces its ability to regulate cell cycle progression and this polymorphism is associated with an increased risk of breast cancer. We analyzed the frequency of RASSF1A A133S in 190 Caucasian women without breast cancer and 653 patients with breast cancer including 138 BRCA1 and BRCA2 (BRCA1/2) mutation carriers, 395 non–BRCA1/2 mutations carriers, and 120 untested for BRCA1/2 mutations. Patients with breast cancer had a higher frequency of A133S than the controls [P = 0.017; odds ratios (OR), 1.71; 95% confidence intervals (95% CI), 1.10–2.66]. There is also a higher frequency of A133S in patients with higher familial breast cancer risk (P = 0.029; OR, 1.76; 95% CI, 1.06–2.92) and patients carrying BRCA1/2 mutations (P = 0.037, OR, 1.82; 95% CI, 1.04–3.18). Importantly, we found that the co-occurrence of a BRCA1 or BRCA2 mutation and A133S in RASSF1A was associated with earlier onset of breast cancer compared with those individuals with either a BRCA1/2 mutation or the A133S polymorphism alone (36.0 versus 42.0 years old, P = 0.002). Our data suggest that the presence of the RASSF1A A133S polymorphism is associated with breast cancer pathogenesis in general and modifies breast cancer age of onset in BRCA1/2 mutations carriers. Our results warrant a large-scale study to examine the effect of the A133S polymorphism in the development of breast and other types of cancers. [Cancer Res 2008;68(1):22–5]
342. Human Erythropoietin Gene Therapy for Patients with Chronic Renal Failure
Authors: Yitzhak Lippin, Michal Dranitzki-Elhale, Einat Brill-Almon, Chava Mei–Zahav, Sarah Mizrachi, Yael Liberman, Adrian Iaina, Eli Kaplan, Eduardo Podjarny, Nicole Casadevall, Noam Shani, Eithan Galun
Journal: Molecular Therapy (2005)

Top of pageAbstract
Background: Gene therapy holds a major promise. However, until now, this promise was fulfilled only in few cases, in rare genetic diseases. One very common clinical condition is anemia. Patients with anemia of chronic renal failure are treated with Erythropoietin. The objective of this study was to develop a therapeutic platform for serum secreted proteins like erythropoietin. Method: We developed a tissue protein factory based on dermal cores (Biopump) harvested and implanted autologously. In this study, an adenovector was designed to express the human Erythropoietin under the control of the CMV promoter. This vector transduced the harvested dermal cores ex vivo. The transduced cores were implanted and Erythropoietin and reticulocyte counts were measured. Results: Dermal cores were harvested from 13 patients with chronic renal failure, and implantation was performed in 10. There were no significant drug related side- effects to this procedure. Erythropoietin serum levels increased significantly to therapeutic levels from day 1 post implantation reaching a peak during the first week of follow-up. The expression period was transient for up to 14 days. The rise of Erythropoietin was followed by a transient significant increase in reticulocyte counts. The decrease of Erythropoietin expression coincided with a significant dermal infiltrate of CD8 cytotoxic T cells. Anti Erythropoietin antibodies were not detected until day 90 following implantation. Conclusion: Implantation of dermal cores ex vivo transduced with human genes could eventually be used in the clinical setting to express therapeutic serum proteins. However, non-immunogenic delivery system should be tested as gene vehicles.

The company Medgenics Inc., Biogenics Ltd had supported this study. However, painfully we must say that the company went out of business recently, and the authors of this abstract have no more financial connections to it.
SPECIAL SANITARY INSTRUCTIONS FOR THE GUIDANCE OF TROOPS SERVING IN TROPICAL COUNTRIES.
Authors: R. S. WOODSON
Journal: JAMA (1898)

Having served in the extreme south during my entire service as a medical officer, viz.: Atlanta, Ga.; Pensacola, Fla.; Laredo, Texas; New Orleans, La.; Savannah, Ga.; and Tampa, Fla., and having made a special study of tropical disease, including yellow fever, it is incumbent upon the writer to publish the following special report of the existing conditions and the sanitary precautions to be taken in tropical climates for the instruction of troops to be sent therein. The existing conditions of international complications lead us to believe that the Island of Cuba is our objective point and while I have never been a resident of the island, yet I have taken advantage of the opportunities offered to obtain all information possible from a number of prominent physicians, refugees from Havana. The adverse sanitary conditions peculiar to Cuba are: 1, numerous infected foci of yellow fever; 2, numerous areas of infection from
Clinical Trials Registry Expands
Authors: Bridget M. Kuehn
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Guancydine: A New Antihypertensive Agent
Authors: DWIGHT W. CLARK
Journal: Annals of Internal Medicine (1972)

Guancydine was investigated as part of three antihypertensive regimens. In regimen I guancydine and the diuretic, quinethazone, were administered to five patients; their blood pressure decreased by an average of 34/28 mm Hg, in the supine position, and 32/28 mm Hg, in the erect position. In regimen II guancydine was administered to 10 patients receiving guanethidine (average dose, 49 mg/day) and quinethazone; their blood pressure decreased by 33/27 mm Hg, supine, and 20/25 mm Hg, erect. Guancydine was also given to eight patients receiving a larger dose of guanethidine (average dose, 234 mg/day) and quinethazone; their blood pressure decreased by 49/25 mm Hg, supine, and 47/23 mm Hg, erect. Similar reductions in the supine pressure occurred in regimen III, when propranolol was substituted for guanethidine in five patients, but orthostasis did not occur with propranolol as with guanethidine. Hyperexcitability in one patient and paresthesia in another required discontinuation of guancydine therapy. These results indicate that guancydine is an effective agent when used in combination with quinethazone, guanethidine, or propranolol.
15-Deoxy-Δ12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-κB activity and down-regulation of antiapoptotic proteins
Authors: Roberto Piva, Patrizia Gianferretti, Alessandra Ciucci, Riccardo Taulli, Giuseppe Belardo, M. Gabriella Santoro
Journal: Blood (2004)
Malignant Transformation in Vitro by Oncogenic Viruses
Authors: Paul H. Black
Journal: JAMA (1968)

In vitro transformation of animal cells by oncogenic viruses offers a controlled methodology with which to study the malignant process. Quantitative studies of viral transformation reveal that up to 50% of cells can be transformed. Examination of the early biochemical events of viral transformation has disclosed that an induction of synthesis of enzymes operative in deoxyribonucleic acid biosynthetic pathways and a stimulation of host DNA synthesis occurs from 12 to 24 hours after infection of the cells. There is an association of these changes, resulting from a disruption of the regulatory mechanisms of host cell metabolism, with viral transformation. There is