tbuckley/cabot-search huggingface dataset:
Variations on the Melanoma Theme
Authors: Frederick A. J. Kingery
Journal: JAMA (1965)

Malignant melanoma is a neoplasm whose course is capricious and unpredictable. Even the most experienced eye encounters difficulty in early recognition of this tumor. The three examples of melanoma on this page are variations from the usual pattern and in each instance provide the clinician with important information. Proper management depends on accurate interpretation of this information.   Amelanotic melanoma (Fig 1) differs from pigmented melanomas only in that the melanocytes do not produce melanin. Highly malignant, this erythematous or flesh-colored nodule arouses suspicion by its erosion and destruction of normal cutaneous structures. Neither more nor less malignant than its pigmented counterpart, the amelanotic lesion is particularly dangerous because it is often unrecognized.   Juvenile melanoma (Fig 2) occurs in prepubertal children and represents a melanocytic nevus which is undergoing such rapid evolution that the microscopic appearance suggests malignancy. These tumors are benign with very rare exceptions. Interpretation by an experienced pathologist
Gerontology Researchers Sharpen Focus but Face More Complex Challenges as 21st Century Looms
Authors: Phil Gunby
Journal: JAMA (1995)

FUTURE LONGITUDINAL studies of aging will examine, among other factors, how the process of growing older reduces independent functioning and increases vulnerability to morbidity and mortality, plus what can be done about this and when to do it. That is the prediction of James L. Fozard, PhD, and some colleagues in Baltimore, Md, at the Gerontology Research Center (GRC), National Institute on Aging (NIA), where the Baltimore Longitudinal Study of Aging (BLSA) has been under way since 1958 (<i>JAMA</i>. 1967;201:32). Fozard, who is the NIA's associate scientific director for the BLSA, says it is important to study prospectively the often subtle age-related changes in the underlying mechanisms of human functioning. That is, many gerontology researchers are saying, it is important to understand those factors associated with aging that lead to the increasing susceptibility to disease and loss of functional ability. <h3>Cost of 'Growing Up'</h3> The underlying mechanisms begin to exert
Mental Health Professionals Find Fewer Problems Than Expected in Desert Storm
Authors: Phil Gunby
Journal: JAMA (1991)

DANGER, discomfort, and drudgery notwithstanding, the mental health of US military personnel participating in Operation Desert Storm is surprisingly good, according to medical data compiled to date. As also is true with the physical health screening, says Richard I. Ridenour, MD, a US Navy rear admiral, a few troops escaped the mental health screening—especially in the early days of the rapid buildup—that might have prevented their being sent to the Middle East in the first place. For example, says Ridenour, who is a psychiatrist: "Some of the people showing symptoms of clinical depression [while participating in Desert Shield and Desert Storm] probably would have been depressed wherever they were." Overall, however, says Frank F. Ledford, Jr, MD, the lieutenant general who is the Army's surgeon general, there have been fewer mental health problems in Desert Shield/Storm units than probably in most of those stationed elsewhere. Ridenour and colleagues add that
Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea
Authors: Andrés Parra, Rodolfo Madrid, Diego Echevarria, Susana del Olmo, Cruz Morenilla-Palao, M Carmen Acosta, Juana Gallar, Ajay Dhaka, Félix Viana, Carlos Belmonte
Journal: Nature Medicine (2010)
From the authors: The Asthma Control Questionnaire for children: still more questions than answers
Authors: E.F. Juniper, K. Gruffydd-Jones, S. Ward, K. Svensson
Journal: European Respiratory Journal (2011)

The Asthma Control Questionnaire for children: still more questions than answersTo the Editors:Optimising control is the main goal in paediatric asthma management and reliable instruments that can help physicians to evaluate asthma control in an easy way are valuable.The article by JUNIPER et al.[1] provides some initial insights on the use of the Asthma Control Questionnaire (ACQ), an instrument that was originally developed for adult asthma, to assess asthma control in children.The process of developing and
Location and size of acute transmural myocardial infarction estimated from thallium-201 scintiscans. A clinicopathological study.
Authors: F J Wackers, A E Becker, G Samson, E B Sokole, J B van der Schoot, A J Vet, K I Lie, D Durrer, H Wellens
Journal: Circulation (1977)

A clinicopathological study was performed in 23 patients who died from acute transmural myocardial infarction and who had been studied with thallium-201 during the acute phase. Twenty patients died within five days and three later than five days after scintigraphy. The scintigraphic location and the estimated size of infarction in vivo were correlated with postmortem findings. There was good agreement in 91% between scintigraphic and postmortem location of infarction and in 70% between the ECG and postmortem findings. The size of infarction as determined from computer-processed schematic drawings of postmortem slices of the heart correlated well with the size determined from processed schematic drawings of the scintiscans (r = 0.91 for anterior infarction, r = 0.97 for inferior infarction, r = 0.86 for anterior-inferior infarction). It is concluded that thallium-201 scintigraphy provided more precise location of infarction than the ECG and that the size of the scintigraphically abnormal area reflected the extent of necrotic myocardium.
SOME POINTS IN THE DIAGNOSIS OF GALL-STONES.
Authors: JAMES B. HERRICK
Journal: JAMA (1901)

Repeated attacks of colic with the pain in the right hypochondrium, accompanied by nausea and vomiting and followed in a few hours by a slight jaundice, leave little doubt as to the existence of gall-stones. In the majority of cases it is on a history of such attacks with the finding of the calculi in the feces that the diagnosis is made.  But the stones are not always so frank in making known their presence. They manifest themselves by irregular symptoms, they simulate other diseases, and other diseases simulate them, so that it is true, as Hoppe-Seyler says, that if the uncomplicated, regular cholelithiasis is difficult to recognize, much more difficult is it to recognize the irregular and complicated form of the disease. 1 It is to some of the symptoms most likely to be misinterpreted and to some diseases liable wrongly to be regarded as gall-stones that I wish
Immunization with SV40-transformed cells yields mainly MHC-restricted monoclonal antibodies.
Authors: B G Froscher, N R Klinman
Journal: The Journal of Experimental Medicine (1986)

Recognition of antigens on cell surfaces only in the context of the MHC-encoded alloantigens of the presenting cell (self + X) has classically been considered the province of T cells. However, evidence from several sources has indicated that B cells and antibodies can exhibit self + X-restricted recognition as well. This report concerns the mAb response to SV40-transformed H-2b fibroblast cell lines. The specificities of the antibodies obtained have been analyzed for binding to a panel of SV40-transformed H-2-syngeneic, H-2-allogeneic, and H-2b mutant fibroblast cell lines, as well as cell lines not bearing cell surface SV40 transformation-associated antigens. A large proportion of primary C57BL/6 (71%) and BALB/c (68%) splenic B cells responding to in vitro stimulation with SV40-transformed H-2b cells recognize cell surface antigens associated with SV40 transformation only when coexpressed with MHC antigens of the immunizing cell, particularly the Kb molecule, on transformed cells. To extensively define the nature of antigen recognition by these antibodies, we have generated and characterized nine hybridoma antibodies specific for SV40-transformed H-2-syngeneic cell lines. Seven of these hybridoma antibodies recognize SV40-associated transformation antigens in the context of H-2b molecules. Six of these are restricted by the Kb molecule and discriminate among a panel of SV40-transformed Kb mutant cell lines, thus confirming the participation of class I MHC-encoded molecules in the recognition by B cells of cell surface antigens.
Volunteers at Risk
Authors: Jeffrey M. Drazen
Journal: New England Journal of Medicine (2006)

Clinical research can be a risky endeavor. In this issue of the Journal, Suntharalingam et al.1 describe the events that occurred when six healthy volunteers received a dose (0.1 mg per kilogram of body weight) of TGN1412 — a superagonistic humanized monoclonal antibody that stimulates and expands T-cell populations independently of the ligation of the T-cell receptor. In all six patients, the cytokine-release syndrome developed, including multiorgan failure. Two of the patients required mechanical ventilation, and all received renal-replacement therapy. All six had severe hypotension, and peripheral ischemia developed in one patient to the extent that surgical treatment was required. . . .
EARLIEST FEATURES OF THE STRAWBERRY MARK IN THE NEWBORN
Authors: AKIRA HIDANO, SHINOBU NAKAJIMA
Journal: British Journal of Dermatology (1972)

Summary.— In 2168 infants, 17 cases of strawberry mark were followed from the earliest neonatal stage. Three angiomata began as telangiectatic lesions surrounded by a pale halo; red puncta then appeared on the dilated vessels. They coalesced and became papular, and red plaques were formed. Three angiomata began as a pale patch; telangiectasia then appeared on this patch. One angioma, first seen as a bruise‐like macule. transformed into a nodular lesion. One angioma began as a simple and uniform erythema and subsequently became nodular. Two infants already showed early haemangiomata at our first examination. In 5 infants, on whom no abnormality was found within the first week of life, a strawberry mark was found later. Two pale patches in the neonatal stage remained abortive angiomata. The haemangiomatous component developed in the majority of cases between the third and fifth weeks of life.
Time Will Tell
Authors: Bryan Sisk
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Relation of coronary heart disease and apolipoprotein E phenotype in patients with non-insulin dependent diabetes.
Authors: M Laakso, A Kesaniemi, K Kervinen, M Jauhiainen, K Pyorala
Journal: BMJ (1991)

OBJECTIVES--To examine the relation between coronary heart disease and the apolipoprotein E phenotypes in patients with non-insulin dependent diabetes mellitus. DESIGN--Cross sectional study. SETTING--District around Kuopio University Central Hospital, East Finland. SUBJECTS--138 men with non-insulin dependent diabetes and 64 men without diabetes as controls. MAIN OUTCOME MEASURE--Apolipoprotein E phenotype, electrocardiographic abnormalities, other signs of coronary heart disease. RESULTS--The prevalences of definite myocardial infarction and ischaemic electrocardiographic changes were highest in the diabetic men with the phenotypes E4/4 or E4/3 (25% (95% confidence interval 18% to 32%) and 50% (42% to 58%) respectively), although the difference between the phenotype groups was not significant. The prevalence of angina pectoris was 69% (61% to 77%) in men with the phenotypes E4/4 or E4/3 (p = 0.005 compared with other phenotypes), 41% (33% to 49%) in men with phenotype E3/3, and 47% (39% to 55%) in those with phenotypes E2/2 or E2/3. Similarly, the simultaneous presence of angina pectoris and ischaemic electrocardiographic changes was highest in the diabetic men with the phenotypes E4/4 or E4/3 (42% v 22% in those with E3/3 and 29% in those with E2/2, E2/3; p = 0.038). Overall, the prevalence of any evidence of coronary heart disease among the diabetic subjects with the phenotypes E4/4 or E4/3 was 81% (p = 0.011 compared with other phenotypes), 58% in those with phenotype E3/3, and 53% in those with phenotypes E2/2 or E3/3. CONCLUSION--Apolipoprotein E phenotypes E4/4 and E4/3 modulate the risk of coronary heart disease in men with non-insulin dependent diabetes.
P228 Efficacy And Safety Of Fluticasone Propionate/formoterol In Paediatric Patients With Asthma
Authors: A. Ploszczuk, M. Bosheva, K. Spooner, T. McIver, S. Dissanayake
Journal: Thorax (2014)

<h3>Background</h3> Fluticasone propionate (FP) and formoterol (FORM) have been combined in a single inhaler (FP/FORM;<b><i>flutiform</i></b><sup>®</sup>) for the treatment of adolescents and adults with asthma. This study assessed the efficacy and safety of FP/FORM in paediatric asthma patients. <h3>Methods</h3> A total of 512 patients aged 5 to &lt;12yrs were randomised 1:1:1 to 12 weeks of treatment with either FP/FORM (100/10 µg BID), FP (100 µg BID) or fluticasone propionate/salmeterol (FP/SAL) (100/50 µg BID) in a double-blind, parallel group, multicentre study. The objectives were to demonstrate superiority of FP/FORM to FP and non-inferiority to FP/SAL. The primary endpoint was the change from predose FEV1 at baseline to 2-hour postdose FEV1 over the 12 weeks. The two key secondary endpoints were FEV1 AUC0–4h at Week 12 and change from pre-dose FEV1 over the 12 weeks. <h3>Results</h3> FP/FORM was superior to FP for change from predose FEV1 at baseline to 2-hour postdose FEV1 (treatment difference = 0.07 L; 95% CI: 0.03, 0.11; p &lt; 0.001) and FEV1 AUC0–4h at Week 12 (treatment difference = 0.09 L; 95% CI: 0.04, 0.13; p &lt; 0.001). FP/FORM was non-inferior to FP/SAL for change from predose FEV1 at baseline to 2-hour postdose FEV1 (treatment difference = -0.00 L; 95% CI: -0.04, 0.04; p &lt; 0.001), AUC0–4h at Week 12 (treatment difference = 0.01 L; 95% CI: -0.03, 0.06; p &lt; 0.001) and change from predose FEV1 (treatment difference = -0.02 L; 95% CI: -0.06, 0.02; p &lt; 0.001). The safety and tolerability profiles of all treatments were similar. <h3>Conclusion</h3> In children 5 to &lt;12yrs with asthma, FP/FORM was superior to FP, and non-inferior to FP/SAL for improvements in lung function, with a similar tolerability profile to both FP and FP/SAL. Disclaimer Acknowledgement: Reproduced with permission of the European Respiratory Society: Eur Resp J September 2014; 44, Suppl. 58: In Press
Eculizumab for Atypical Hemolytic–Uremic Syndrome
Authors: Jens Nürnberger, Thomas Philipp, Oliver Witzke, Anabelle Opazo Saez, Udo Vester, Hideo Andreas Baba, Andreas Kribben, Lothar Bernd Zimmerhackl, Andreas R. Janecke, Mato Nagel, Michael Kirschfink
Journal: New England Journal of Medicine (2009)

To the Editor: Atypical hemolytic–uremic syndrome is a disease of uncontrolled complement activation associated with a high mortality rate, and most cases progress to end-stage renal disease.1 About 50% of patients with this syndrome carry mutations in genes encoding complement proteins.2 Complement inhibition has been suggested for the treatment of atypical hemolytic–uremic syndrome,3 but currently no data on this treatment option are available. We report on a case of atypical hemolytic–uremic syndrome that was successfully treated with eculizumab, a humanized monoclonal antibody that blocks complement activity by cleavage of the complement protein C5, thereby preventing the generation of the inflammatory . . .
Cellular immune reconstitution after subcutaneous alemtuzumab (anti-CD52 monoclonal antibody, CAMPATH-1H) treatment as first-line therapy for B-cell chronic lymphocytic leukaemia
Authors: J Lundin, A Porwit-MacDonald, E D Rossmann, C Karlsson, P Edman, M R Rezvany, E Kimby, A Österborg, H Mellstedt
Journal: Leukemia (2004)
Treadmill Exercise Testing
Authors: Robert Detrano
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 May 1987Treadmill Exercise TestingROBERT DETRANO, M.D.Ph.D.ROBERT DETRANO, M.D.Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-5-771_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Studies about exercise testing have been criticized because of methodologic flaws in their reporting (1, 2). The article by Armstrong and associates (3) deserves such criticism. The authors conclude that exercise echocardiography adds complementary information to that given by exercise electrocardiography for the diagnosis of angiographic coronary disease. This conclusion is largely based on the results of both exercise tests given to 44 patients with angiographic disease but without previous myocardial infarction. The authors report that only 19 patients had ischemic exercise electrocardiograms, whereas 35 had abnormal exercise echocardiograms. To arrive at this unusually low sensitivity for...References1. DIAMOND G. Monkey business. Am J Cardiol. 1986;57:471-5. CrossrefMedlineGoogle Scholar2. PHILBRICKHORWITZFEINSTEIN JRA. Methodologic problems of exercise testing for coronary artery disease: groups, analysis, and bias. Am J Cardiol. 1980;46:807-12. CrossrefMedlineGoogle Scholar3. ARMSTRONGO'DONNELLDILLONMCHENRYMORRISFEIGENBAUM WJJPSH. Complementary value of two-dimensional exercise echocardiography to routine treadmill exercise testing. Ann Intern Med. 1986;105:829-35. LinkGoogle Scholar4. FROELICHER V. Exercise testing and training: clinical applications. JACC. 1983;1:946-55. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT DETRANO, M.D.Ph.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe diagnostic accuracy of the exercise electrocardiogram: A meta-analysis of 22 years of research 1 May 1987Volume 106, Issue 5Page: 771-771KeywordsEchocardiographyElectrocardiographyExerciseMyocardial infarction ePublished: 1 December 2008 Issue Published: 1 May 1987 PDF downloadLoading ...
Influence of antipseudomonal agents on Pseudomonas aeruginosa colonization and acquisition of resistance in critically ill medical patients
Authors: José A. Martínez, Esther Delgado, Sara Martí, Francesc Marco, Jordi Vila, Josep Mensa, Antoni Torres, Carles Codina, Antoni Trilla, Alex Soriano, Aitor Alquezar, Pedro Castro, José M. Nicolás
Journal: Intensive Care Medicine (2008)
Record number of fake drugs are seized in crackdown
Authors: J. Wise
Journal: BMJ (2013)

Counterfeit and unlicensed drugs worth £12.2m (€14.2m; $18.6m) have been seized in the United Kingdom as part of an international crackdown on the illegal internet trade.

The UK Medicines and Healthcare Products Regulatory Agency (MHRA) worked with customs officials, the police, and agencies around the world as part of Operation Pangea VI. The week long operation resulted in 58 people being arrested worldwide and the seizure of 9.9 million doses of unlicensed and fake drugs, worth around £26.8m. Drugs seized included those for erectile dysfunction, weight loss, cancer, acne, and depression.

The operation, coordinated by Interpol, involved 99 countries and resulted …
Clinical Factor 2012
Authors: Richard Balon
Journal: Psychotherapy and Psychosomatics (2013)

of Sex and Marital Therapy, Psychological Medicine, Psychosomatics and Psychotherapy and Psychosomatics . I view myself first and foremost as a clinician (though academically oriented) and I am, as most clinicians are, looking for a way to help patients, and thus looking for new, or innovative, or newly validated treatments. Thus that is part of my clinician’s bias and that impacts my selection – the majority of the selected articles are on treatment-related issues or long-term outcome. I had originally selected more articles and it has been difficult to narrow them down to the final 19. I am sure I missed some interesting ones, but as noted, this is a subjective selection.
Rationale and design of ARTS: a randomized, double‐blind study of BAY 94‐8862 in patients with chronic heart failure and mild or moderate chronic kidney disease
Authors: Bertram Pitt, Gerasimos Filippatos, Mihai Gheorghiade, Lars Kober, Henry Krum, Piotr Ponikowski, Christina Nowack, Peter Kolkhof, So‐Young Kim, Faiez Zannad
Journal: European Journal of Heart Failure (2012)
Cell associated urokinase activity and colonic epithelial cells in health and disease.
Authors: P R Gibson, E van de Pol, W F Doe
Journal: Gut (1991)

It is not known if urokinase-type plasminogen activator (uPA) is associated with normal colonic epithelial cells. The aims of this study were to determine if normal colonic epithelial cells have uPA activity and whether this is concentrated at the cell membrane. In addition, the contribution of colonic epithelial cell associated uPA activity to disease related pertubations of mucosal uPA activity were examined. A highly enriched population of colonic epithelial cells was isolated from resected colon or biopsy specimens by an enzymatic technique. uPA activity was measured in cell homogenates by a specific and sensitive colorimetric method and expressed relative to cellular DNA. In two experiments subcellular fractionation of colonic epithelial cells was performed by nitrogen cavitation followed by ultracentrifugation over a linear sucrose gradient. The fractions collected were analysed for uPA and organelle-specific enzyme activities. Normal colonic epithelial cells have cell associated uPA activity (mean (SEM) 5.6 (1.1) IU/mg, n = 18). This colocalised with fractions enriched for leucine-beta-naphthylamidase and 59-nucleotidase, markers of plasma membrane. uPA activities in epithelial cells from cancerous colons (9.8 (3.1) n = 7) or from mucosa affected by inflammatory bowel disease (3.8 (0.7) n = 15) were not significantly different from normal (paired t test), while that in epithelial cells from greatly inflamed mucosa was similar to that from autologous normal or mildly inflamed areas (4.4 (1.2) v 5.9 (3.6), n = 9). Thus normal colonic epithelial cells have cell associated uPA activity which is concentrated on the plasma membranes, suggesting the presence of uPA receptors. Increased mucosal levels of uPA previously reported in patients with inflammatory bowel disease are not due to increased colonic epithelial cell associated uPA.