Octreotide-Induced Manic Episodes in a Patient with Acromegaly
Authors: José-Manuel Fernández-Real, Mónica Recasens, Wifredo Ricart
Journal: Annals of Internal Medicine (2006)

Letters2 May 2006Octreotide-Induced Manic Episodes in a Patient with AcromegalyJosé-Manuel Fernández-Real, MD, PhD, Mónica Recasens, MD, and Wifredo Ricart, MDJosé-Manuel Fernández-Real, MD, PhDFrom Hospital de Girona Doctor Josep Trueta, 17007 Girona, Spain.Search for more papers by this author, Mónica Recasens, MDFrom Hospital de Girona Doctor Josep Trueta, 17007 Girona, Spain.Search for more papers by this author, and Wifredo Ricart, MDFrom Hospital de Girona Doctor Josep Trueta, 17007 Girona, Spain.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-9-200605020-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: Psychotic reactions have been well documented in patients receiving therapy with low doses of bromocriptine (1) and other dopaminergic agonists. Dopamine stimulates somatostatin release. In animals, somatostatin influences a wide spectrum of behavioral functions, including learning, regulation of slow-wave sleep, and locomotor activity. These functions are often altered in patients with manic episodes (2), and some alterations have also been described in humans after administration of octreotide (3).Objective: To describe a patient with acromegaly in whom the administration of the long-acting somatostatin analogue octreotide precipitated a manic episode on 2 occasions.Case Report: Acromegaly was clinically and biochemically ...References1. Pearson KC. Mental disorders from low-dose bromocriptine [Letter]. N Engl J Med. 1981;305:173. [PMID: 7242593] CrossrefMedlineGoogle Scholar2. Rubinow DR, Davis CL, Post RM. Somatostatin in neuropsychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry. 1988; 12 Suppl S137-55. [PMID: 2907936] CrossrefMedlineGoogle Scholar3. Ziegenbein M, Held K, Kuenzel HE, Murck H, Antonijevic IA, Steiger A. The somatostatin analogue octreotide impairs sleep and decreases EEG sigma power in young male subjects. Neuropsychopharmacology. 2004;29:146-51. [PMID: 12955096] CrossrefMedlineGoogle Scholar4. Sharma RP, Bissette G, Janicak PG, Davis JM, Nemeroff CB. Elevation of CSF somatostatin concentrations in mania. Am J Psychiatry. 1995;152:1807-9. [PMID: 8526251] CrossrefMedlineGoogle Scholar5. Nyegaard M, Borglum AD, Bruun TG, Collier DA, Russ C, Mors O, et al. Novel polymorphisms in the somatostatin receptor 5 (SSTR5) gene associated with bipolar affective disorder. Mol Psychiatry. 2002;7:745-54. [PMID: 12192619] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Hospital de Girona Doctor Josep Trueta, 17007 Girona, Spain.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByOctreotide-LAR-associated erythema multiforme in an acromegalic subject: case report 2 May 2006Volume 144, Issue 9Page: 704KeywordsAcromegalyAttentionBlood plasmaCarbonatesDopamineGrowth hormoneInsulin-like growth factorsSomatostatinThyroid-stimulating hormoneThyroxine ePublished: 2 May 2006 Issue Published: 2 May 2006 CopyrightCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...