Reversal of Severe Renal Failure in Systemic Sclerosis
Authors: MILDRED LAM
Journal: Annals of Internal Medicine (1978)

Brief Reports1 November 1978Reversal of Severe Renal Failure in Systemic SclerosisMILDRED LAM, M.D., EDMOND S. RICANATI, M.D., MUHAMMAD A. KHAN, M.D., M.R.C.P., F.A.C.P., IRVING KUSHNER, M.D., F.A.C.P.MILDRED LAM, M.D.Search for more papers by this author, EDMOND S. RICANATI, M.D.Search for more papers by this author, MUHAMMAD A. KHAN, M.D., M.R.C.P., F.A.C.P.Search for more papers by this author, IRVING KUSHNER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-5-642 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRenal failure in systemic sclerosis, with or without malignant hypertension, is regarded as progressive and irreversible, leading to death within weeks to months (1, 2). We have recently seen a patient with systemic sclerosis and severe renal involvement who showed marked improvement in renal function while receiving chronic renal dialysis and antihypertensive therapy, permitting discontinuation of dialysis 1 year after onset of renal failure.A 48-year-old black woman was hospitalized in June 1976 with a 1-month history of anorexia and fatigue, and shortness of breath on...References1. CANNON P, HASSAR M, CASE D, CASARELLA W, SOMMERS S, and LEROY E: The relationship of hypertension and renal failure in scleroderma (progressive systemic sclerosis) to structural and functional abnormalities of the renal cortical circulation. Medicine (Baltimore) 53:1-46, 1974 CrossrefMedlineGoogle Scholar2. MEDSGER T and MASI A: Survival with scleroderma. II. A life-table analysis of clinical and demographic factors in 358 male U.S. veteran patients. J Chronic Dis 26:647-660, 1973 CrossrefMedlineGoogle Scholar3. KEANE W, DANIELSON B, and RAIJ L: Successful renal transplantation in progressive systemic sclerosis. Ann Intern Med 85:199-202, 1976 LinkGoogle Scholar4. MERINO G, SUTHERLAND D, KJELLSTRAND C, SIMMONS R, and NAJARIAN J: Renal transplantation for progressive systemic sclerosis with renal failure: case report and review of previous experience. Am J Surg 133:745-749, 1977 CrossrefMedlineGoogle Scholar5. CAMPBELL P and LEROY E: Pathogenesis of systemic sclerosis: a vascular hypothesis. Semin Arthritis Rheum 4:351-368, 1975 CrossrefMedlineGoogle Scholar6. LEROY E and FLEISHMANN R: The management of renal scleroderma. Experience with dialysis, nephrectomy and transplantation. Am J Med 64:974-978, 1978 CrossrefMedlineGoogle Scholar7. WASNER C, COOK C, and FRIES J: Survival with medical management after scleroderma renal crisis (abstract). Arthritis Rheum 21:600-601, 1978 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MILDRED LAM, M.D.; EDMOND S. RICANATI, M.D.; MUHAMMAD A. KHAN, M.D., M.R.C.P., F.A.C.P.; IRVING KUSHNER, M.D., F.A.C.P. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySyndromes hémolytiques et urémiques de l’adulteSyndromes hémolytiques et urémiques de l'adulteMalignant HypertensionMalignant vascular disease of the kidney: Nature of the lesions, mediators of disease progression, and the case for bilateral nephrectomyRecovery of Renal Function in Patients on Maintenance DialysisOutcome of Renal Crisis in Systemic Sclerosis: Relation to Availability of Angiotensin Converting Enzyme (ACE) InhibitorsVirginia D. Steen, MD, Joseph P. Costantino, DrPH, Alvin P. Shapiro, MD, Thomas A. 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ABRUZZO, M.D. 1 November 1978Volume 89, Issue 5_Part_1Page: 642-643KeywordsAntihypertensive drug therapyDyspneaFatigueHypertensionMedical dialysisRenal failureScleroderma ePublished: 1 December 2008 Issue Published: 1 November 1978 PDF downloadLoading ...