Age at Cancer Diagnosis Among Persons With AIDS
Authors: Meredith S. Shiels, Ruth M. Pfeiffer, Eric A. Engels
Journal: Annals of Internal Medicine (2011)

Letters3 May 2011Age at Cancer Diagnosis Among Persons With AIDSMeredith S. Shiels, PhD, MHS, Ruth M. Pfeiffer, PhD, and Eric A. Engels, MD, MPHMeredith S. Shiels, PhD, MHSFrom National Cancer Institute, Rockville, MD 20892., Ruth M. Pfeiffer, PhDFrom National Cancer Institute, Rockville, MD 20892., and Eric A. Engels, MD, MPHFrom National Cancer Institute, Rockville, MD 20892.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-9-201105030-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We recently illustrated that naively comparing the ages at cancer diagnosis between persons with AIDS and the general population is inappropriate because the age distributions of the populations at risk differ. After adjustment for these population differences, we found that persons with AIDS do not develop most types of cancer at younger ages than the general population.Although other investigators have suggested that elevated cancer risk at all ages could be evidence of accelerated aging (1), we posited that accelerated aging requires particularly elevated cancer risk at young ages, which would lead to a downward shift in the ...References1. Martin J, Volberding P. HIV and premature aging: a field still in its infancy [Editorial]. Ann Intern Med. 2010;153:477-9. [PMID: 20921548] LinkGoogle Scholar2. Engels EA, Biggar RJ, Hall HI, Cross H, Crutchfield A, Finch JL, et al. Cancer risk in people infected with human immunodeficiency virus in the United States. Int J Cancer. 2008;123:187-94. [PMID: 18435450] CrossrefMedlineGoogle Scholar3. Kaldor JM, Day NE. Mathematical models in cancer epidemiology.. In: Schottenfeld D, Fraumeni JF Jr, eds. Cancer Epidemiology and Prevention. 2nd ed. New York: Oxford Univ Pr; 1996:127-40. Google Scholar4. Shiels MS, Pfeiffer R, Gail MH, Hall HI, Li J, Chaturvedi A et al. The burden of cancer among HIV-infected people in the United States. Journal of the National Cancer Institute. [Forthcoming]. Google Scholar Author, Article, and Disclosure InformationAffiliations: From National Cancer Institute, Rockville, MD 20892.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M10-1342. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAge at Cancer Diagnosis Among Persons With AIDS in the United States Meredith S. Shiels , Ruth M. Pfeiffer , and Eric A. Engels HIV and Premature Aging: A Field Still in Its Infancy Jeffrey Martin and Paul Volberding Age at Cancer Diagnosis Among Persons With AIDS Charlotte Sakarovitch and Eric Fontas Age at Cancer Diagnosis Among Persons With AIDS Mari M. Kitahata , Chad J. Achenbach , and Michael S. Saag Metrics 3 May 2011Volume 154, Issue 9Page: 643KeywordsAIDSAge distributionAgingCancer screeningCarcinogenesisConflicts of interestDisclosureHIVProstate cancer ePublished: 3 May 2011 Issue Published: 3 May 2011 CopyrightCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...