tbuckley/cabot-search huggingface dataset:
Letter: Multiple factors in the hyperlipidaemia of hypervitaminosis D.
Authors: V Linden, M S Seelig
Journal: BMJ (1975)

At start of On recovery At start of At end of Gentamicin from illness Gentamicin Gentamicin Effect of gentamicin on renal function (creatinine clearance) in six oliguric patients (left-hand column) and 23 patients with stable renal function (right-hand column).associated with transplant rejection.The authors give no indication as to the renal pathology in four patients whose function deteriorated to such an extent that they re- quired graft nephrectomy or dialysis but im- plied that gentamicin was the causative agent.We suggest that there is a wide gap
Obesity drug, genetic studies renew hope for autism therapy
Authors: Tom Hager
Journal: JAMA (1983)

Joey looks like a normal 3-year-old. But left by himself in a room full of toys, he ignores everything except a mechanical top that he spins again and again, staring, flapping his hands, and squealing. He plays only with that top, in only that way, over and over. Joey's fixed, repetitive actions seem as mechanical as his favorite plaything. Joey is autistic. At the recent meeting of the National Society for Children and Adults With Autism in Salt Lake City, participants saw several videotapes of Joey playing as part of a presentation on a new treatment for this baffling developmental disorder. Joey was next shown after receiving experimental therapy with fenfluramine hydrochloride (a sympathomimetic amine used to treat obesity) for four months. In the same room, with the same toys, he now chose a toy train set, first putting together tracks, then pushing the train along while making choo-choo noises.
Intestinal Manifestations of Fabry's Disease
Authors: JOHN W. ROWE
Journal: Annals of Internal Medicine (1974)

Four adult patients with Fabry's disease had intestinal involvement. One was asymptomatic, and three suffered from episodic diarrhea. In one patient, diarrhea was the only clinical manifestation of Fabry's disease. Radiologic studies revealed similar changes in the small and large bowels of all four patients. Small bowel changes consisted of thickening of folds and mild dilatation throughout and the presence of an unusual granular appearance of the ileum. Barium enemas showed loss of the colonic haustral markings, particularly in the more distal colonic segments. Serial studies on the symptomatic patients, before and after the onset of diarrhea, showed progression of the radiographic changes. There was no evidence of malabsorption or gastrointestinal blood loss in any of the patients. Intestinal involvement may be common in Fabry's disease.
Effect of cimetidine on lower oesophageal sphincter.
Authors: R J Bailey, S N Sullivan, B R Macdougall, R Williams
Journal: BMJ (1976)

abnormal coagulation results, confirmed the diagnosis of disseminated intravascular coagulation.The transfusion of freeze-dried plasma (which has little if any coagulant activity), fibrinogen concentrate, and whole blood that she was given before admission would have had no appreciable effect on the coagulation results obtained and would not have caused the appearance of FDPs or fragmented red cells.Twelve hours later the prothrombin time was 16 s (control 14 s); partial thromboplastin time 45 s (control 35 s); and thrombin time 15 s (control 12 s).FDPs in the serum still exceeded 40 mg/ml and the film showed occasional fragmented red cells.
Medical Care in Sweden
Authors: Birgitta Borulf
Journal: JAMA (1976)

To the Editor.—  It would be unfortunate if the readers ofThe Journalwould base their opinion about Swedish health care on the false and biased allegations made by our colleague Dr Lofstead (232:1328, 1975). Obviously, he has completely failed to understand the basic ideas of Swedish medical care.  As in the United States, we have in our country private practitioners in addition to publicly employed physicians. It is only by continual expansion of the public health care system, however, that we have been able to fulfill our aims: to guarantee every citizen optimal medical care independent of economic status. Of course, there are problems in Swedish health care. A shortage of physicians has been a limiting factor for several years. Nevertheless, every acutely ill person will get adequate care without delay (12 crowns [$3]) and everyone, if needed, gets specialist and hospital care without further expense.  Waiting lines for
INTEROBSERVER AND INTRAOBSERVER REPRODUCIBILITY OF AORTIC VALVAR COMPLEX MEASUREMENTS AND TRANSCATHETER AORTIC VALVE REPLACEMENT DEPLOYMENT ANGLES BY MULTIDETECTOR COMPUTED TOMOGRAPHY
Authors: Ran Heo, Dan Kalra, Ashley Giambrone, Millie J. Gomez, Jonathon Leipsic, Shing-Chiu Wong, Arash Salemi, Robert Minutello, Geoffrey W. Bergman, Fay Lin, James Min
Journal: Journal of the American College of Cardiology (2014)
'HIV Specialists': The Time Has Come
Authors: Abigail Zuger
Journal: JAMA (1997)

THE PLACE OF acquired immunodeficiency syndrome (AIDS) in the structure of medical care delivery is still evolving. One important consideration is whether the care of persons infected with the human immunodeficiency virus (HIV) should be part of general practice or specialty care. Like many specialists (physicians with advanced training and/or certification in an area of medicine), physicians who care for patients infected with HIV face a spectrum of conditions that are rare, complicated, difficult to manage, and require familiarity with a rapidly expanding medical knowledge base. Still, commentary has emphasized that "AIDS is a primary care disease," citing the need to destigmatize patients, improve disease recognition and prevention, and forestall any shortage of appropriately trained specialists as HIV infection becomes more prevalent nationwidw.<sup>1-3</sup>"Because patients with AIDS can be cared for effectively by primary care physicians," maintains one policy statement, "they [the physicians] should acquire the necessary skills and
TCTAP A-183 Impact of Dyslipidemia on 3-year Clinical Outcomes in Patients with Significant Coronary Artery Spasm
Authors: Byoung Geol Choi, Seung-Woon Rha, Se Yeon Choi, Yoonjee Park, Akkala Raghavender Goud, Hu Li, Sunki Lee, Ji Bak Kim, Sung Il Im, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2014)
Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis
Authors: Matthias Nahrendorf, Hanwen Zhang, Sheena Hembrador, Peter Panizzi, David E. Sosnovik, Elena Aikawa, Peter Libby, Filip K. Swirski, Ralph Weissleder
Journal: Circulation (2007)

Background— Macrophages participate centrally in atherosclerosis, and macrophage markers (eg, CD68, MAC-3) correlate well with lesion severity and therapeutic modulation. On the basis of the avidity of lesional macrophages for polysaccharide-containing supramolecular structures such as nanoparticles, we have developed a new positron emission tomography (PET) agent with optimized pharmacokinetics to allow in vivo imaging at tracer concentrations. Methods and Results— A dextranated and DTPA-modified magnetofluorescent 20-nm nanoparticle was labeled with the PET tracer 64 Cu (1 mCi/0.1 mg nanoparticles) to yield a PET, magnetic resonance, and optically detectable imaging agent. Peak PET activity 24 hours after intravenous injection into mice deficient in apolipoprotein E with experimental atherosclerosis mapped to areas of high plaque load identified by computed tomography such as the aortic root and arch and correlated with magnetic resonance and optical imaging. Accumulated dose in apolipoprotein E–deficient aortas determined by gamma counting was 260% and in carotids 392% of respective wild-type organs ( P &lt;0.05 both). Autoradiography of aortas demonstrated uptake of the agent into macrophage-rich atheromata identified by Oil Red O staining of lipid deposits. The novel nanoagent accumulated predominantly in macrophages as determined by fluorescence microscopy and flow cytometry of cells dissociated from aortas. Conclusions— This report establishes the capability of a novel trimodality nanoparticle to directly detect macrophages in atherosclerotic plaques. Advantages include improved sensitivity; direct correlation of PET signal with an established biomarker (CD68); ability to readily quantify the PET signal, perform whole-body vascular surveys, and spatially localize and follow the trireporter by microscopy; and clinical translatability of the agent given similarities to magnetic resonance imaging probes in clinical trials.
INPATIENT ENDOSCOPY: REFERRAL APPROPRIATENESS AND EFFICIENCY OF SERVICE PROVISION
Authors: W J Tee, G Chan, Z Ahmed, O Jagun, S Brady, M Buckley, S Sarwar, C Smyth, R Farrell
Journal: Gut (2013)

<h3>Introduction</h3> There is an increasing burden on endoscopy units in Ireland to reduce waiting lists and to provide an efficient service. This is compounded by the introduction of the colorectal screening programme, the initiation of the medical assessment unit and the hiring freeze on endoscopy personnel. Therefore, it is essential that all inpatient endoscopy referral indications are appropriate and that provision is made to ensure that requests are dealt with efficiently, without delaying patient discharge. <h3>Aims/Background</h3> To evaluate the appropriateness of inpatient endoscopy requests as well as to assess the efficiency of inpatient endoscopy service provision. <h3>Method</h3> All inpatient endoscopy requests were included prospectively from 20th November 2012 to 21st January 2013. Appropriateness of referral indication was compared against the American Society of Gastroenterology guidelines as well as criteria pre-determined by gastroenterology consultants or registrars in the department. Efficiency of service was evaluated by reviewing the significance of endoscopic findings and if the endoscopic procedures facilitated earlier discharge from hospital. <h3>Results</h3> 30 requests for inpatient endoscopy were received over the study period, mean age 68.3±13.4 years. This accounted for a total of 5.7% endoscopic procedures performed during the period (30/527). 27/30 (90.0%) of the requests were thought to be appropriate. 2/30(6.7%) requests were cancelled by the gastroenterology team due to poor patient clinical status. 1/30 patient was cancelled due to poor indication as the patient had normocytic anaemia secondary to chronic renal failure. There were 11 (40.7%) requests for oesophagogastroduedenoscopy (OGD), 3 (11.1%) for colonoscopy, 5(18.5%) for OGD and colonoscopy, 6 (22.2%) for percutaneous endoscopic gastrostomy(PEG) tube insertion and 2 (7.4%) for sigmoidoscopy. Of the appropriate referrals, the most common indications were microcytic anaemia in 8/27 (29.6%) patients, PEG insertion in 6 (22.2%) patients and dysphagia in 4 (14.8%) patients <h3>Conclusion</h3> Almost all of the inpatient endoscopy requests were thought to be appropriate, confirming that hospital doctors have good awareness for referral indications. The endoscopy service provided in our hospital is very efficient with more than half of patients undergoing their procedures within a day of referral.
CHRONIC DYSPEPSIA IN CHILDREN OF SCHOOL AGE
Authors: F. S. Langmead
Journal: BMJ (1929)

THE term chbronic dvspepsia " in children is used to con1note a groulp of symptoms, varying in degree and in proportioi, which togetlier form a commoni cliniceal licture.For the most part it arouses nio memorv of exact miiorbid anatomly or of precise deviationis fromii tile normial in functional activity.The picture preseilted to our minds is somewhlat as follows.The child is ailing, dull, anid listless, lackilg vitality and comiposuire.The appetite is poor and capricious, time tongue coated, and the breath heavy and perhaps foul.The complexion is muddy, while the facies, with sunken eyes, or puffy eyelids and dai-k orbital rings, is itself characteristic enough to suggest the nature of time malady.There may be abdotainal pains of varying degrees of sever ity, from slight discomfort to attacks of colic; or pain may be absenit.The pa in may occur after food, but is seldom gastric in position, beinig more often about the umbilicus or aloimg the course of the large intestine.It mcay be related to the passage of flatus or precede defaecation.The general nutrition is usually im- paii^d, the child losinig weight in sever-er forms, failing to gaini wveight in milder.On the otlher hand, the weight may be satisfactory but there is a general tonielessness of skinl amid muscles.The stools are variable, in some cases in- frequent, in others too frequ,imt, but always irregular.They may be unev-en in their consistence, particoloured, offensive, and conitaini miiucus or even blood, anid food whicli lias not been digested.There may be slight niocturnal fem-cr, perhlaps witlh bouits of Iiiglier fev-er, coincidently witlh u'hich tlhe odour of the breath anld the abdomiilal symiptoms become more evidenit.Slecp is restless, ofteni disturbed by dreams or nlighlt terrors.Ill some cases there is wakefulness.In the morlning the child is tired and drowsy, anid dislikes getting up.Durinig the day he is easily exhausted anid fatigued, liable to headaches, and lacks concentration or ilnterest in his school work, being slow in acquiisition and poor in performalniice.Psychical symnptotizs take aln im- portant place, but are more prominent in somie cases thani ii others, dependinig in tlleir degree, i part at least, on lhereditary psychlical traits.The child is apt to be morose, despondemnt, resistant, anid irritable, solitary in habit, takinig nio part in gaames, and subject to fits of crying amid of temper.Examination of thle abdomeni may reveal no
Variable Mortality Rates among Dialysis Treatment Centers
Authors: William M. McClellan, W. Dana Flanders, Robert A. Gutman
Journal: Annals of Internal Medicine (1992)

Objective: To examine the variation in the risk for mortality among patients treated at renal dialysis facilities within a defined geographic area. Setting: All free-standing and hospital-based dialysis facilities in a single southeastern state reported to the registry. Design: Cohort of dialysis patients followed for 1 year by an end-stage renal disease registry. Patients: Patients (n = 3612) aged 20 years and older receiving treatment at the dialysis facilities reporting to the registry during 1987. Measurements: Demographic, comorbid, and severity of illness indicators were abstracted from patient records. Facility-specific risk estimates were derived from a Cox proportional hazards model. Results: Facility-specific mortality rates ranged between 2.0 and 10.5 deaths per 10 000 patient days. Mortality rates were higher among older persons; whites; those with a history of diabetic nephropathy, angina, or congestive heart failure; and patients with either nutritional or functional status impairment. Facility-specific prevalence of each mortality risk factor varied widely. The unadjusted risk for death in a facility at the 75th percentile of risk was 1.3 times that of a facility at the median, whereas at the 25th percentile, it was 0.68 times as likely—a twofold range of risk. Controlling for differences in the prevalence of patient characteristics did not change the interquartile range in risks, and a facility's adjusted risk estimate showed a strong correlation with its unadjusted estimate (R2, 0.566; P < 0.0001). Conclusions: Patient attributes associated with increased risk for mortality vary widely among dialysis facilities. Adjustment for these differences did not, however, substantially change either the degree of variation in mortality risks or the relative ranking of a facility's mortality.
Inhibition of Toll-like receptor 2 reduces cardiac fibrosis by attenuating macrophage-mediated inflammation
Authors: Lei Wang, Yu-Lin Li, Cong-Cong Zhang, Wei Cui, Xia Wang, Yong Xia, Jie Du, Hui-Hua Li
Journal: Cardiovascular Research (2013)

AimsToll-like receptor 2 (TLR2) is an important player in innate immunity, and recent studies have identified TLR2 as a critical mediator in cardiovascular diseases. Here, we investigated the involvement of TLR2 in angiotensin (Ang) II-induced cardiac fibrosis and the underlying mechanisms.
Evaluation of Tri-Iodothyronine in the Treatment of Acute Alcoholic Intoxication
Authors: H. Kalant, G. Sereny, Rita Charlebois
Journal: New England Journal of Medicine (1962)

A reliable and effective treatment that could be counted upon to produce rapid sobering of acutely intoxicated patients, with a minimum of hang-over or withdrawal symptoms, would be of obvious value both in the treatment of alcoholism and in medicine generally. Many claims have been advanced in the past for treatments that were said to have all these virtues, but until now not one has proved both safe and effective. Several reports have recently appeared concerning the effects of intravenous or oral administration of tri-iodothyronine in the treatment of both chronic alcoholism and acute intoxication, but these reports are very . . .
Toxic Effect of Stramonium Simulating LSD Trip
Authors: Joseph N. DiGiacomo
Journal: JAMA (1968)

Four cases of stramonium poisoning in teen-agers secondary to ingestion of Asthmador asthmatic powder (stramonium-belladonna mixture) presented as LSD reactions. The clinical manifestations were acute brain syndrome and physical signs of atropinization. The effects of stramonium ingestion are similar to the effects of the ingestion of amphetamine and LSD, but in addition to the psychosis due to toxic reaction, the patient who has ingested stramonium typically has dry mucous membranes and is hot and flushed.
Roentgenologic Diagnosis of Incipient Left Heart Failure
Authors: Constantine S. Soter
Journal: JAMA (1961)

Left heart failure has been studied in 50 patients over a period of 2 1/2 years in order to determine the criteria of early x-ray diagnosis. By evaluating the hilar areas, the pulmonary veins, the parenchyma of the lungs, the costophrenic regions, and the contour and size of the heart, the authors were able to suggest the diagnosis of left heart failure in the earliest stage. The signs were consistent and diagnostic. They were informative in patients who had only vague complaints and atypical or minimal physical findings. They were also useful in assessing the reponse to treatment and detecting early recurrence.
Celery allergy associated with birch and mugwort pollinosis
Authors: B. Wüthrich, J. Stäger, S. G. O. Johansson
Journal: Allergy (1990)

Skin prick tests (SPT) with various celery, carrot and potato preparations (raw, cooked, cooking water of each vegetable and allergen extracts) as well as specific IgE determinations by RAST to celery mix, celeriac (or root cellery), stick celery and heated celery extracts were performed in 70 patients with positive prick or intracutaneous tests to birch and/or mugwort pollens and celery (extract and/or raw). 94% of the patients showed positive prick tests to raw celeriac, 36% to cooked celeriac and 8/13 to cooking water. Celery‐birch positive patients ( n = 13) showed negative or low RASTs to heated celery extracts and to stick celery. By contrast, in the celery‐mugwort sensitive patients ( n = 6) the celery RASTs with heated celery extracts remained clearly positive and high RAST values to stick celery could be found. Celery‐birch‐mugwort‐association ( n = 22) favoured more positive results with relatively high values of RAST to celeriac. The results of homologous and heterologous RAST inhibition experiments with birch, mugwort, unheated and heated celery (100°C) carried out in nine celery‐RAST positive sera are also discussed.
Increased immunoreactivity of plasma after fibrinolytic activation in an anti-DD ELISA system. Role of soluble crosslinked fibrin polymers.
Authors: C W Francis, K Doughney, B Brenner, K Klingbiel, V J Marder
Journal: Circulation (1989)

After addition of a low concentration of thrombin to normal plasma, a progressive and significant increase in crosslinked fibrin polymers was found by sodium dodecyl sulfate agarose gel electrophoresis, reaching 27% of total fibrinogen and fibrin before gel formation. As measured by enzyme-linked immunosorbent assay with a monoclonal antibody specific for an epitope near the gamma gamma crosslink site, increased immunoreactivity of plasma did not occur after adding thrombin despite formation of crosslinked fibrin polymers, which indicates that the antibody does not recognize the epitope in the polymers. Addition of tissue-type plasminogen activator (t-PA) to plasma resulted in a more rapid degradation of fibrin polymers than of fibrinogen, indicating that the fibrin specificity of t-PA is retained with soluble fibrin. Coincident with degradation of plasma crosslinked fibrin polymers, plasma DD immunoreactivity increased 70-fold from 50.3 +/- 4.5 (mean +/- SD) to 3,560 +/- 1,235 ng/ml. The presence of increased crosslinked fibrin polymers produced by adding thrombin to plasma significantly increased maximum immunoreactivity after t-PA-induced degradation to 18,500 +/- 11,780 ng/ml. The increase in DD immunoreactivity was dependent on t-PA concentration; no elevation occurred below 0.01 micrograms/ml, and maximal increases occurred above 100 micrograms/ml. Analysis of gel electrophoretic patterns of thrombin and t-PA-treated plasma samples suggests that the DD reactivity of t-PA-treated plasma is mainly due to degradation of soluble crosslinked fibrin polymers. Our findings indicate that plasmic degradation of soluble fibrin polymers in plasma may be an important source of fragment DD during thrombolytic therapy.
Geriatrics and the Congress
Authors: THEODORE R. REIFF
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 November 1972Geriatrics and the CongressTHEODORE R. REIFF, M.D.THEODORE R. REIFF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-77-5-816_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Since my last letter (77:475, 1972) on gerontology and geriatric medical programs in the medical schools of this country, progress has continued.It is now a virtual certainty that Congress will pass a bill this year along the lines of the Rogers bill in the House and the Eagleton bill in the Senate. This will establish a National Institute for Aging Research.The separate bill (S.2931) by Senator Frank Moss of Utah, a member of the Senate's Special Committee on Aging, to fund up to six medical schools in the country, each with up to $500 000/... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: THEODORE R. REIFF, M.D.Affiliations: Health Action Council Department of Employment and Social Services Commission on Aging Baltimore, Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1972Volume 77, Issue 5Page: 816-816KeywordsAgingGeriatrics ePublished: 1 December 2008 Issue Published: 1 November 1972 PDF downloadLoading ...
Homozygosity for Hemochromatosis: Clinical Manifestations
Authors: CORWIN Q. EDWARDS
Journal: Annals of Internal Medicine (1980)

We identified 35 homozygotes for hemochromatosis through pedigree studies. Thirteen were asymptomatic. Arthropathy was present in 20, hepatomegaly in 19, transaminasemia in 16, skin pigmentation in 15, splenomegaly in 14, cirrhosis in 14, hypogonadism in six, and diabetes in two. No homozygote was in congestive failure. Only one had the triad of hepatomegaly, hyperpigmentation, and diabetes. Serum iron was increased in 30 of 35, transferrin saturation was increased in all 35, serum ferritin in 23 of 32, urinary iron excretion after deferoxamine in 28 of 33, hepatic parenchymal cell stainable iron in 32 of 33, and hepatic iron in 27 of 27. Iron loading was 2.7 times greater in men than in women. No female had hepatic cirrhosis. Diagnosis of asymptomatic hemochromatosis is important because organ damage may be prevented by early therapy. Clinical diagnosis of early hemochromatosis is difficult. Persons with unexplained elevation of transferrin saturation should be studied for hemochromatosis.