tbuckley/cabot-search huggingface dataset:
A pro-inflammatory role for Th22 cells in<i>Helicobacter pylori</i>-associated gastritis
Authors: Yuan Zhuang, Ping Cheng, Xiao-fei Liu, Liu-sheng Peng, Bo-sheng Li, Ting-ting Wang, Na Chen, Wen-hua Li, Yun Shi, Weisan Chen, Ken C Pang, Ming Zeng, Xu-hu Mao, Shi-ming Yang, Hong Guo, Gang Guo, Tao Liu, Qian-fei Zuo, Hui-jie Yang, Liu-yang Yang, Fang-yuan Mao, Yi-pin Lv, Quan-ming Zou
Journal: Gut (2014)

Helper T (Th) cell responses are critical for the pathogenesis of Helicobacter pylori-induced gastritis. Th22 cells represent a newly discovered Th cell subset, but their relevance to H. pylori-induced gastritis is unknown.Flow cytometry, real-time PCR and ELISA analyses were performed to examine cell, protein and transcript levels in gastric samples from patients and mice infected with H. pylori. Gastric tissues from interleukin (IL)-22-deficient and wild-type (control) mice were also examined. Tissue inflammation was determined for pro-inflammatory cell infiltration and pro-inflammatory protein production. Gastric epithelial cells and myeloid-derived suppressor cells (MDSC) were isolated, stimulated and/or cultured for Th22 cell function assays.Th22 cells accumulated in gastric mucosa of both patients and mice infected with H. pylori. Th22 cell polarisation was promoted via the production of IL-23 by dendritic cells (DC) during H. pylori infection, and resulted in increased inflammation within the gastric mucosa. This inflammation was characterised by the CXCR2-dependent influx of MDSCs, whose migration was induced via the IL-22-dependent production of CXCL2 by gastric epithelial cells. Under the influence of IL-22, MDSCs, in turn, produced pro-inflammatory proteins, such as S100A8 and S100A9, and suppressed Th1 cell responses, thereby contributing to the development of H. pylori-associated gastritis.This study, therefore, identifies a novel regulatory network involving H. pylori, DCs, Th22 cells, gastric epithelial cells and MDSCs, which collectively exert a pro-inflammatory effect within the gastric microenvironment. Efforts to inhibit this Th22-dependent pathway may therefore prove a valuable strategy in the therapy of H. pylori-associated gastritis.
Relationship between nutritional status and the glomerular filtration rate: Results from the MDRD Study
Authors: Joel D. Kopple, Tom Greene, W. Cameroon Chumlea, Donna Hollinger, Bradley J. Maroni, Donna Merrill, Laura K. Scherch, Gerald Schulman, Shin-Ru Wang, Gail S. Zimmer
Journal: Kidney International (2000)
IT-34 * PILOT STUDY OF COMBINATION OF ANTITUMOR IMMUNOTHERAPY TARGETED AGAINST CYTOMEGALOVIRUS (CMV) PLUS REGULATORY T-CELL INHIBITION IN PATIENTS WITH NEWLY-DIAGNOSED GLIOBLASTOMA MULTIFORME (GBM)
Authors: G. Vlahovic, G. Archer, D. Lally-Goss, E. Reap, K. Batich, A. Desjardins, K. Peters, T. Ranjan, P. Healy, J. Herndon, A. Friedman, H. Friedman, D. Bigner, J. Sampson
Journal: Neuro-Oncology (2014)

BACKGROUND: Despite aggressive surgery, high-dose focused radiation, and multimechanistic chemotherapy, malignant gliomas (MG) remain almost universally fatal. The inherent biologic specificity of immunotherapy offers the prospect of targeting neoplastic cells more precisely. Dendritic cells (DCs) are endowed with an extraordinary ability to activate CD4+ and CD8+ T-cells, and DCs loaded with antigens derived from tumor cells (CMV pp65-LAMP mRNA) have the potential to induce potent antitumor immunity. Furthermore, regulatory T-cells (TRegs) which induce a state of reversible immunosuppression in MG and can be functionally inactivated with anti-CD25 antibody (Ab), while dramatically enhance vaccine-induced immune responses. METHODS: Eligible were gross totally resected patients (pts) with newly diagnosed GBM. Pts underwent leukapheresis followed by standard of care radiation/temozolomide (XRT/TMZ) therapy. After completion of XRT/TMZ, up to 12 cycles of TMZ 200 mg/m2/x5d were administered. Around Day 21 of the 1st cycle pts also received: anti-CD25 Ab treatment and vaccine #1. Vaccines #2 and #3 were given biweekly following vaccine#1. On Day 21 of the 2nd TMZ cycle Vaccine #4 was administered. Pts were followed with serial MRIs until disease progression. RESULTS: 7 patients (5 males) were treated. No adverse events attributable to vaccine treatment were observed. Median progression free survival was 23.5 months (95% CI:1.7 to 54.1). Median overall survival was 30.3 months (95% CI:11.8 to 60.8). Overall survival was calculated from the start of vaccine therapy to time of death or last contact if alive. CONCLUSION: Treatment with XRT/TMZ, DC vaccine and anti- CD25 Ab was well tolerated and produced encouraging PFS and OS resulting in now ongoing Phase I study. Due to the lack of adverse events the number of vaccines had been increased to 8 (vs. 4) and anti-CD25 antibody is being given with the first two cycles (vs. with 1st cycle only) of adjuvant TMZ.
Clinical Evaluation of Cytodiagnosis in Bronchial Carcinoma
Authors: H. L. D. Duguid, D. W. Huish
Journal: BMJ (1963)

BRONCHIAL CARCINOMAJBoRrn 287clinically and radiologically, was virtual complete resolution.It is, however, recognized that bone destruction and joint involvement can give rise to deformity and disability in the vaccinial as well as the variolar form of osteitis.We wish to thank Mr.
Psychiatric Implications of Acquired Immune Deficiency Syndrome
Authors: Julia Bess Frank
Journal: JAMA (1985)

Even among life-threatening illnesses, the acquired immunodeficiency syndrome (AIDS) is unique. First recognized only five years ago, it is a lethal, contagious disease that preferentially affects members of stigmatized social groups (male homosexuals and drug abusers), and its victims are often relatively young, potentially productive members of society. The intense responses it evokes from sufferers, populations at risk, and society as a whole present a special challenge to psychiatry. This American Psychiatric Association monograph is a concise, inexpensive, and timely report on the state of psychiatric knowledge and practice in this area. Overall, the book contains valuable information that will be new to those who have not yet seen many persons with AIDS. The quality of the reports is uneven, however, and certain important questions are hardly discussed. The strongest articles are those on the medical and neurological implications of the syndrome. Uniformly clear and concise, these three chapters discuss
Community hospitals: an under-recognized resource for palliative care
Authors: S. Payne, C. Kerr, S. Hawker, D. Seamark, C. Davis, H. Roberts, N. Jarrett, P. Roderick, H. Smith
Journal: Journal of the Royal Society of Medicine (2004)

In the UK there are concerns that, in certain groups of dying patients such as the old, those with non-cancer diagnoses and those in rural areas, the quality of care is unacceptably variable. There has been no systematic survey of the extent to which community hospitals provide general palliative care for such patients. Therefore, by means of a structured questionnaire we asked senior nurses/managers at all 478 community hospitals in the UK for information on staff expertise, facilities and specialist equipment, liaison arrangements with specialist palliative care providers, priorities, practice and policy in end-of-life care. Of the 346 hospitals (72%) that responded, only 28 were in urban areas. 73% of hospitals employed at least one nurse with additional training in palliative care, 72% had access to 24-hour specialist palliative care advice and 51% had separate overnight accommodation for relatives, but only 22% had designated palliative care beds. Most hospitals did not have written policies or guidelines for patient assessment or symptom control. These findings add to evidence that community hospitals represent an important resource to improve access to palliative care for groups that are currently under-served.
Fever! The Hunt for a New Killer Virus
Authors: Elliott B. Oppenheim
Journal: JAMA (1974)

In 1969, in Lassa, Nigeria, a Church of the Brethren missionary, Laura Wine, became ill. Fever was the most prominent feature, but there were many fevers in Lassa. The camp physician, John Hamer, was at first unconcerned. As the fever progressed to profound illness, Dr. Hamer's worry mounted. Laura Wine died 11 days after the onset of her illness. This atypical pattern and tragic death marked the beginning of a medical mystery story so perplexing that identification of Lassa fever virus required combined efforts of the United Nations World Health Organization, the Center for Disease Control (CDC) in Atlanta, the virus laboratories at Yale University, the Rockefeller Foundation virologists, and cost several more lives. The laboratories at Yale were unable to contain this virus, and several researchers died. When research was halted, the CDC continued to conduct experimentation in the maximum security facilities. The threat of Africa being struck by
IgG and IgM core antibodies and viral replication in hepatitis C virus carriers
Authors: Nobukazu Yuki, Norio Hayashi, Hideki Hagiwara, Masafumi Naito, Kazuyoshi Ohkawa, Kazuhiro Katayama, Akinori Kasahara, Hideyuki Fusamoto, Takenobu Kamada
Journal: Journal of Hepatology (1994)
Aberrant Left Coronary Artery
Authors: HARVEY COHEN, SHIRLEY SIEW
Journal: Circulation (1959)

A case is reported of the anomalous origin of the left coronary artery from the pulmonary artery in a Bantu male infant aged 9 months. The clinical, radiologic, and electrocardiographic findings, and the cardiac pathology are presented. The 45 cases previously reported in the literature are reviewed and the clinical syndrome and pathologic physiology of the aberrant left coronary artery are discussed.
A case of taxane-induced scleroderma: a different expression profile of Fli1 proteins in dermal fibroblasts and microvascular endothelial cells compared with systemic sclerosis
Authors: T. Takahashi, Y. Asano, Y. Ichimura, T. Taniguchi, A. Kogure, Z. Tamaki, T. Takekoshi, M. Sugaya, S. Sato
Journal: British Journal of Dermatology (2011)

Funding sources: none. Conflicts of interest: none declared. Madam, A 58‐year‐old woman with a 3‐year history of widespread breast cancer was admitted to our hospital in February 2010 because of a progressive thickening of the skin. In 1998, she had undergone left mastectomy for breast cancer. In August 2007, weekly paclitaxel infusion (100 mg m−2) was started against multiple bone metastasis. In June 2009, oedema of the lower legs appeared, with progressive thickening of the skin. The thickening and oedema also appeared in both arms in December 2009, and she was referred to our hospital. On examination, prominent oedema and skin thickening had spread all over the extremities, especially severely in the lower extremities. A characteristic cobblestone‐like appearance with pigmentation and depigmentation was seen on the lower legs and the forearms (Fig. 1a,b). Neither Raynaud’s phenomenon, digital pitting scars, telangiectasia nor nailfold capillary changes were detected. Laboratory investigations were negative for rheumatoid factor and antinuclear antibody and revealed no abnormalities in the number of white blood cells and platelets, lactate dehydrogenase, surfactant protein‐D and electrolyte levels, while anaemia (haemoglobin 9·0 g dL−1) and elevated KL‐6 levels (7484 U mL−1) were notable due to metastatic tumour. Extensive searches including chest computed tomography and pulmonary function tests revealed no visceral involvement. Skin biopsy from the right forearm showed diffuse dermal fibrosis with telangiectatic vessels and a slight lymphocytic perivascular infiltrate without mucin deposition (Fig. 1c). Fibrosis of the fascia was not seen. There were deposits of melanin pigment in the epidermal basement zone. While the clinical and histological findings closely resembled systemic sclerosis (SSc), vascular involvements such as Raynaud’s phenomenon, telangiectasia and nailfold changes, and immunological abnormalities were absent. Considering these findings collectively, she was diagnosed with taxane‐induced scleroderma. Therefore, oral prednisone 20 mg daily was initiated, with the discontinuation of paclitaxel. The oedema and the skin sclerosis of the extremities gradually started to resolve at around 1 month and 3 months afterwards, respectively.
Is low plasma 25-(OH)vitamin D a major risk factor for hyperparathyroidism and Looser's zones independent of calcitriol?
Authors: Abderhaman Ghazali, Patrice Fardellone, André Pruna, Ahcene Atik, Jean-Michel Achard, Roxana Oprisiu, Michel Brazier, Alex Remond, Philippe Morinière, Michèle Garabedian, John Eastwood, Albert Fournier
Journal: Kidney International (1999)
Infectious Diseases Associated with Renal Homotransplantation.
Authors: David Rifkind
Journal: Annals of Internal Medicine (1964)

s1 October 1964Infectious Diseases Associated with Renal Homotransplantation.David Rifkind, Ph.D., M.D., Thomas Startzl, M.D., Ph.D., Thomas L. Marchioro, M.D., William R. Waddell, M.D.David Rifkind, Ph.D., M.D.Search for more papers by this author, Thomas Startzl, M.D., Ph.D.Search for more papers by this author, Thomas L. Marchioro, M.D.Search for more papers by this author, William R. Waddell, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-4-815_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSerious to fatal infections have occurred in 19 of the first 30 renal homotransplantations at The University of Colorado Medical Center and have constituted a primary factor in seven of the ten deaths that have occurred in this group. Immunologic attenuation of the recipient is accomplished by thymectomy and splenectomy, and more recently by splenectomy alone, plus azathioprine. In essentially all patients, homograft rejection tends to occur in the first post-transplant month, and this reaction must be suppressed by actinomycin C and by massive doses of corticosteroids.The period of maximal risk from bacterial infections occurs at the time of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Denver, Colo. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1964Volume 61, Issue 4Page: 815-815KeywordsHomograftsHomotransplantationInfectious diseasesRenal diseasesSplenectomyThymectomy Issue Published: 1 October 1964 PDF DownloadLoading ...
Medicine and Dialects
Authors: CHASE PATTERSON KIMBALL
Journal: Annals of Internal Medicine (1971)

Editorials1 January 1971Medicine and DialectsCHASE PATTERSON KIMBALL, M.D.CHASE PATTERSON KIMBALL, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-1-137 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe Physician speaks a strange and often unintelligible dialect. He calls everyday common objects by absurd and antiquated terms. He speaks of mitral commissurotomies, pituitary insufficiency, and reality feed-back. This world is peopled with cirrhotics, green-sticks, and hebephrenics. The professional dialect creates a communication gap between physician and patient that is generally acknowledged by neither. Not only does the physician speak a strange dialect, but more often than not he fails to recognize the dialects of his patients (1-3).In order to trace the dialect of the physician it is necessary to recognize that medicine as a profession is a...References1. BOYLE C: Difference between patients' and doctors' interpretation of some common medical terms. Brit Med J 2:286-289, 1970 CrossrefMedlineGoogle Scholar2. HABERMAN P: Ethnic differences in psychiatric symptoms reported in community surveys. Public Health Rep 85:495-502, 1970 CrossrefMedlineGoogle Scholar3. MILLWARD C: Familiar English for foreign doctors. New Eng J Med 283:430-431, 1970 CrossrefMedlineGoogle Scholar4. KIMBALL C: A case of pseudocyesis caused by roots. Amer J Obstet Gynec 107:801-803, 1970 CrossrefMedlineGoogle Scholar5. TINLING D: Voodoo, root work, and medicine. Psychosom Med 29:483-490, 1967 CrossrefMedlineGoogle Scholar6. LEIGHTONLEIGHTON DA: The Navaho Door. Cambridge, Harvard University Press, 1944 CrossrefGoogle Scholar7. EDWARDS J: Sinners in the hands of an angry God, in American Heritage: An Anthology and Interpretive Survey of Our Literature, edited by HOWARD L, WRIGHT D, BODE C. Indianapolis, D. C. Heath, 1955 Google Scholar8. JUNG C: Chapter 7, in The Collected Works of C. G. Jung, vol. 7, edited by READ H, FORDHAM M, ADLER G. New York, Pantheon Books, Inc., 1953 Google Scholar9. IMATAGLIACOGZOLASHOF KDJ: Physician orientation and behavior: a study of outpatient clinic physicians. Med Care 8:189-199, 1970 CrossrefMedlineGoogle Scholar10. KIMBALL C: Yale's program in intracultural medicine. J Med Educ. In press Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Yale University New Haven, Conn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDriving Miss Evers' Boys to the Historical Tuskegee Study of Untreated SyphilisDialect Is DiagnosticJOHN F. BURNUM, M.D.Health Communication Theory and Research: An Overview of the Communication Specialist InterfaceThe Patient's Right to clear Communications in Health and Mental Health Delivery ServiceThe Medical Interview 1 January 1971Volume 74, Issue 1Page: 137-139 Issue Published: 1 January 1971 PDF DownloadLoading ...
Positive discrimination is still elitist
Authors: K. Patel
Journal: BMJ (2010)

Imagine a profession filled with ageing white men, men of great power and sometimes great wisdom, with many years of experience. Some used their power to appoint other white men to replace them. And some used their power inappropriately because they didn’t like anyone who wasn’t white like them. Not all were bad, but there was a conspiracy of silence covering all this up until the whole house of cards fell down.

I’m talking not about medicine but the police. Last week the conviction of the corrupt Metropolitan Police commander …
EFFECT OF INTENSIVE COMPARED WITH STANDARD BLOOD GLUCOSE CONTROL IN PATIENTS WITH TYPE 2 DIABETES MELLITUS IN DIFFERENT REGIONS OF THE WORLD: SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Authors: Partha Sardar, Saurav Chatterjee, Jacob Udell, Sameer Bansilal, Debabrata Mukherjee, Michael Farkouh
Journal: Journal of the American College of Cardiology (2014)
THE TREATMENT OF SCARLATINA ANGINOSA
Authors: P. H. Chavasse
Journal: BMJ (1856)

ry weak and ineective, and indeed the membaes re wery lightly affected during their continuance; a consi- urabl sized portion of placenta was felt in connexion withihem.On applying my hand on the abdomen during the con- taction of the uterus, I ascertained that this organ did not th become hard and resitant, but it continued softish.Under these circumstances, we concluded first to pass the on 14 July
Ontario starts colorectal cancer screening programme for adults aged 50-74
Authors: David Spurgeon
Journal: BMJ (2007)

Ontario has announced that it will become the first Canadian province to set up a province-wide screening programme for the early detection of colorectal cancer. This type of cancer has the second highest death toll of cancers in Canada. 

The Ontario government says its scheme is the first such screening programme in North America to use the faecal occult blood test. Other countries that already have such a programme are Australia, Italy, France, Finland, and Israel. The …
Hypereosinophilia in a monosomy 7 myeloproliferative disorder in childhood
Authors: M. J. Humphrey, J. J. Hutter, W. W. Tom
Journal: American Journal of Hematology (1981)

Abstract Hyperosinophilia in association with a monosomy 7 myeloproliferative disorder is described in an eight‐year‐old boy. Antileukemic treatment resulted in a decrease in the eosinophilia, but did not appear to affect the blast cell population or the presence of monosomy 7 cells in the bone marrow. These findings suggest that bone marrow karyotyping may be useful in differentiating pre‐malignant causes of eosinophilia from those with a more benign etiology.
392 Two novel conserved motifs in the hepatitis C virus NS3 protein critical for helicase action
Authors: D FRICK, A LAM, D KEENEY
Journal: Hepatology (2003)

CshA is a dimeric DEAD-box helicase that cooperates with ribonucleases for mRNA turnover. The molecular mechanism for how a dimeric DEAD-box helicase aids in RNA decay remains unknown. Here, we report the crystal structure and small-angle X-ray scattering solution structure of the CshA from Geobacillus stearothermophilus. In contrast to typical monomeric DEAD-box helicases, CshA is exclusively a dimeric protein with the RecA-like domains of each protomer forming a V-shaped structure. We show that the C-terminal domains protruding outward from the tip of the V-shaped structure is critical for mediating strong RNA binding and is crucial for efficient RNA-dependent ATP hydrolysis. We also show that RNA remains bound with CshA during ATP hydrolysis cycles and thus bulk RNAs could be unwound and degraded in a processive manner through cooperation between exoribonucleases and CshA. A dimeric helicase is hence preserved in RNA-degrading machinery for efficient RNA turnover in prokaryotes and eukaryotes.
Oral Contraceptive Use and the Occurrence of Pituitary Prolactinoma
Authors: Kirkwood K. Shy
Journal: JAMA (1983)

To determine whether prior oral contraceptive (OC) use is a risk factor for pituitary prolactinoma, we attempted to identify all women (n = 72) with a prolactinoma diagnosed between 1976 and 1980 in three counties in western Washington. A control group of 303 women was selected by dialing random telephone numbers from the same counties. Prior OC use, according to OC indication, was ascertained during a standardized telephone interview. Relative to the risk for women who had never used an OC, the risk of prolactinoma for women who had used OCs for birth control was 1.3 (95% confidence interval, 0.7 to 2.6). This risk was 7.7 for women who used OCs for menstrual regulation (95% confidence interval, 3.7 to 17.0). Previous findings of an association between OC use and prolactinoma may have resulted from OC treatment of menstrual irregularity in women with an undiagnosed prolactinoma.
Treatment of Cushing's Disease in Childhood and Adolescence by Transsphenoidal Microadenomectomy
Authors: Dennis M. Styne, Melvin M. Grumbach, Selna L. Kaplan, Charles B. Wilson, Felix A. Conte
Journal: New England Journal of Medicine (1984)

Fifteen unselected children and adolescents with Cushing's disease were treated by transsphenoidal exploration and microadenomectomy. In only three patients was radiographic examination of the sella turcica, including computed tomography, useful in indicating the presence and location of a pituitary microadenoma. Transsphenoidal microadenomectomy corrected hypercortisolism in 14 of the 15 patients; no adenoma was detected in one patient, and one required a second operation six months after the first because of incomplete removal of the adenoma. All 14 lost weight and cushingoid stigmata and had normal or catch-up growth (if epiphyses were not fused) and progression of puberty. In one patient, a recurrence was successfully treated by repeat microadenomectomy six years after the first procedure. The low morbidity and failure rate of the procedure, the low recurrence rate, the rapid amelioration of signs of hypercortisolism, and the preservation of pituitary function in the present study support transsphenoidal microadenomectomy as a low-risk approach to the initial treatment of Cushing's disease in childhood and adolescence. (N Engl J Med 1984;310:889–93.)
One-year follow-up of the SIRIUS study: A randomized study with the sirolimus-eluting Bx VELOCITY in the treatment of patients with denovo native coronary artery lesions
Authors: David R. Holmes, Martin B. Leon, Jeffrey W. Moses, Jay Midwall, Mel Clark, Igor Palacios, Mark Bates, John Lopez, Alan C. Yeung, Richard E. Kuntz
Journal: Journal of the American College of Cardiology (2003)