tbuckley/cabot-search huggingface dataset:
Hypoparathyroidism and Pseudo-hypoparathyroidism
Authors: R. R. de Mowbray, S. H. L. Smith, W. J. C. Symonds
Journal: BMJ (1954)

Hypoparathyroidism is well recognized as a complication of thyroidectomy.In most series of cases reported in the literature the incidence has been less than 1 % after operations for hyperthyroidism, the figures ranging from 0.2% (Cattel, 1934) to 3.5% (Lachmann, 1941); in about half the cases the tetany is only transient.Idiopathic hypoparathyroidism is generally regarded as a rarity.Only 60 to 70 proved cases have been recorded in the literature, and only three of these have been reported from this country (Humphreys, 1939; Hims- worth and Maizels, 1940; Jordan and Kelsall, 1951).Still rarer, perhaps, is the condition of pseudo-90 hypoparathyroidism, described by O 80 CASE 0 o 40 UN'ITS Albright et al. (1942), which results -PARA-THOR -MONE I.V.from abnormal resistance to para-E 7'°t hyroid hormone rather than from -60 deficient secretion.Only 18 cases x 50 have so far been reported.0 40We have been impressed by the X 30 variety of ways in which this group < 20. of disorders may present, and by the to.ease with which they may escape ' recognition.We believe that they , 2 3 4 HOI -may not be as rare as is commonly supposed.We therefore record three 8 PARAT cases of idiopathic hypoparathyroid-70 ism, together with three illustrative C cases of the post-operative condition L , and one case of pseudo-hypopara-.thyroidism.This last case has 0 40 already been reported elsewhere I 3 (Bishop and de Mowbray, 1951), 20 and is, so far as we are aware, the z ,o first to be recorded in this country.;Case 1. Idiopathic Hypoparathyroidism This patient, a man aged 44, first noticed stiffness of his leg muscles after mild exercise when aged about 12.At 22 he began to develop progressive Jfailure of vision, at 40 a cataract was removed from his left eye.At the age of 32 he began to have carpopedal spasms, and between the attacks he had
HIV Infection Associated With Injections of Anabolic Steroids
Authors: Michael J. Scott
Journal: JAMA (1989)

<h3>To the Editor.—</h3> We report a case of acquired immunodeficiency syndrome (AIDS) virus transmission by intramuscular injection. <h3>Report of a Case.—</h3> A 26-year-old white male bodybuilder requested tests for AIDS. He was asymptomatic but said that for the past 3 years he and a fellow bodybuilder had been taking black-market anabolic androgenic steroids in cycles. To administer the intramuscular injectable steroids, primarily testosterone cypionate and testosterone proprionate, they shared a hypodermic needle on approximately 60 occasions without sterilization. No other individuals used their needle or syringe. Four months previously his friend, who he only now discovered was homosexual, had developed symptoms of AIDS and subsequently had been diagnosed as having AIDS. Our patient therefore was concerned about the possibility of contamination from the shared needle. He was in excellent health, heterosexual, and married for 5 years and gave no history of extramarital affairs. A detailed history revealed no other potential
When industrial relations break down.
Authors: N Ellis
Journal: BMJ (1980)

The Government has taken a further step towards devolving responsibility for industrial relations policy to local health authorities. New guidelines on handling industrial disputes published by the DHSS express the Government's determina tion to stand well back from these and not interfere: Ministers want NHS management to know that, having issued this guidance, they would hope not to intervene in their decisions. The emphasis throughout the circular, // Industrial Relations Break Down,1 is on the need for NHS management to exercise its discretion when dealing with industrial disputes. It is not unusual for management to prepare confidential advice on how to handle disputes, particularly in a sector as strike prone as the NHS. But it is rare for such guidance to be issued as a public document. The DHSS has done just this by publishing these new guidelines, which describe how manage ment can respond to industrial action by making use of agency staff and volunteers and by contingency planning. The guide lines arise from a study by some regional and personnel administrators of the problems that occurred during last winter's industrial action. Indeed, most parts of the document may be attributed to lessons learned from the specific circum stances of particular disputes occurring during the past year or so.
METABOLISM OF ACID MUCOPOLYSACCHARIDES IN THE SHWARTZMAN PHENOMENON
Authors: Gerald S. Berenson, Edward R. Dalferes
Journal: The Journal of Experimental Medicine (1960)

The effect of the Shwartzman phenomenon on the metabolism of the acid mucopolysaccharides (MPS), hyaluronic acid and chondroitin sulfate, from rabbits with localized lesions was studied. Quantitative changes of MPS were observed by two techniques—the in vivo incorporation of glucose C14 into the MPS and the in vitro dilution of C14-labeled MPS. The results indicate an increased concentration of both MPS fractions in the skin lesions and suggest an increased biosynthesis of the compounds at the site of the lesions. Deposition of chondroitin sulfate from blood may have contributed in part to the concentration of this substance in the lesions. The MPS contribute to the inflammatory state of the Shwartzman phenomenon but the specific roles of these compounds need to be defined by further study.
Expensive helmets do not correct skull flattening in babies
Authors: Z. Kmietowicz
Journal: BMJ (2014)

Babies whose skulls become deformed from lying in the same position for long periods do not benefit from wearing a corrective helmet, a study has found.

The Helmet therapy Assessment in Deformed Skills (HEADS) randomised trial investigated the treatment of positional skull deformation or plagiocephaly, which affects around a fifth of babies under the age of 6 months. The condition has become more common since parents were advised to lay their babies on their backs to sleep to reduce the risk …
First do no harm: a response to Louise Ansari, Diabetes UK
Authors: K. Asimakopoulou, J. Speight, T. Skinner
Journal: BMJ (2014)

We were interested to read the letter from Diabetes UK’s director of communications defending the organisation’s recent campaign designed to raise awareness of the seriousness of type 2 diabetes.1

The campaign, showing various versions of tearful adults, offered no concrete knowledge message except for the emotional devastation associated with diabetes. Such fear campaigns do not help prompt preventive health action unless they also offer the target audience meaningful ways to engage in reducing the …
A blinded multicenter dose escalation phase IIa study of the factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in patients undergoing elective percutaneous coronary intervention
Authors: Amo H. Moons, N.R. Bijsterveld, H.R. Büller, M.H. Prins, W.E. Rote, G.P. Vlasuk, R.J. Peters
Journal: Journal of the American College of Cardiology (2002)
Allergic Airway Inflammation (AAI) Decreased Lung Klebsiella Pneumoniae Burden in a Mouse Model of Acute Pneumonia
Authors: Daniel E. Dulek, Sara Reiss, Kasia Goleniewska, Dawn C. Newcomb, Shinji Toki, R. Stokes Peebles
Journal: Journal of Allergy and Clinical Immunology (2013)
Improving Emergency-Room Patient Follow-up in a Metropolitan Teaching Hospital
Authors: Suzanne W. Fletcher, Francis A. Appel, Michele Bourgois
Journal: New England Journal of Medicine (1974)

Abstract A randomized controlled study was conducted to determine whether addition of a Follow-up Clerk to the emergency-room staff would improve compliance among emergency-room patients requiring follow-up observation for nonurgent conditions. Two hundred and ninety-one patients scheduled either for x-ray studies with follow-up clinic visits or for follow-up clinic visits because of hypertension were randomized into Intervention and Control Groups. For the Intervention Group, the Clerk reminded patients of scheduled appointments, offered assistance and followed them to ensure completion of x-ray examination or return to clinic (or both). Eighty per cent of the Intervention Group and 58 per cent of the Control Group returned to the clinic (p<0.001). Thirty-seven per cent of the Intervention Group required assistance beyond routine reminders. Intervention was associated with higher compliance regardless of age, race, sex, marital or employment status. Thus, addition of a Follow-up Clerk in the emergency room may significantly improve patient return for follow-up care. (N Engl J Med 291:385–388, 1974)
A Circular Letter to Leprologists.
Authors: Albert S. Ashmead
Journal: JAMA (1897)

New York, Aug. 13, 1897. The following resolutions will be presented at the Berlin Lepra-Conference, Oct. 11 to 16, 1897. <i>Resolved</i>, That it is the opinion of the delegates of Government, and the leprologists here assembled, that all goverments shall be invited to appoint official delegates (one from each country) to form a<i>permanent</i>committee for the suppression and prevention of leprosy, to meet first in Berlin in October, 1898; these delegates to be salaried by their respective governments, and to have full charge of all matters pertaining to leprosy in their own countries. <i>Resolved</i>, That the German Government be requested to send this invitation through its state department to all governments concerned. May I count on your support for having these resolutions passed?AlbertS.Ashmead. <h3>NON BIS, SED CENTIES, IN IDEM.</h3> Independently of any differences between Dr. Ehlers and myself, which can only be side issues; independently of
Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD
Authors: Y Lu, J Kitaura, T Oki, Y Komeno, K Ozaki, M Kiyono, H Kumagai, H Nakajima, T Nosaka, H Aburatani, T Kitamura
Journal: Leukemia (2007)
Ampicillin Rash and Hyperuricemia
Authors: TIMOTHY F. MURPHY
Journal: Annals of Internal Medicine (1979)

Letters1 August 1979Ampicillin Rash and HyperuricemiaTIMOTHY F. MURPHY, M.D.TIMOTHY F. MURPHY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-2-324_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In his excellent review on the management of gout in the May 1979 issue (1), Dr. Simkin discusses the approach to asymptomatic hyperuricemia. A related consideration for clinicians to be aware of in caring for these patients is the increased incidence of rash associated with ampicillin administration. The Boston Collaberative Drug Surveillance Program reported a 22.4% incidence of rash in patients receiving ampicillin and allopurinol concomitantly (2). The explanation for this observation is not known, but an altered immunologic reactivity in hyperuricemic persons may be responsible (3). This is particularly applicable to patients with tumors undergoing chemotherapy,...References1. SIMKIN P. Management of gout. Ann Intern Med. 1979;90:812-6. LinkGoogle Scholar2. . Excess of ampicillin rashes associated with allopurinol or hyperuricemia. N Engl J Med. 1972;286:505-7. CrossrefMedlineGoogle Scholar3. FESSEL W. Immunologic reactivity in hyperuricemia. N Engl J Med. 1972;286:1218. Letter. CrossrefMedlineGoogle Scholar4. PULLEN H, WRIGHT N, and MURDOCH J. Hypersensitivity reactions to antibacterial drugs in infectious mononucleosis. Lancet. 1967;2:1176-8. CrossrefMedlineGoogle Scholar5. KLEMORA E. Hypersensitivity reactions to ampicillin in cytomegalovirus mononucleosis. Scand J Infect Dis. 1970;2:29-31. CrossrefMedlineGoogle Scholar6. CAMERON S and RICHMOND J. Ampicillin hypersensitivity in lymphatic leukaemia. Scott Med J. 1971;16:425-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: TIMOTHY F. MURPHY, M.D.Affiliations: Tufts New England Medical Center Boston, MA 02111 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCutaneous Reactions to Antibacterial AgentsIDENTIFYING SKIN REACTIONS TO DRUGSAllergic Cutaneous Reactions to DrugsCutaneous drug reactions: Pathogenesis and clinical classificationPenicillins and Cephalosporins 1 August 1979Volume 91, Issue 2Page: 324-324KeywordsAllopurinolChemotherapyDrugsGoutRashes ePublished: 1 December 2008 Issue Published: 1 August 1979 PDF downloadLoading ...
Coughs cause systemic blood flow
Authors: W. C Little
Journal: Thorax (1985)

Coughs cause systemic blood flow Sir,-I read with interest the report by Dr JM Cary and colleagues entitled "Coughs cause systemic blood flow" (March 1984;39: 192-5).Their observation that coughs limited to diastole produce peripheral arterial flow is entirely in agreement with our observations.'Our study, however, demonstrated that, unless the precough aortic pressure is very low, the increased intrathoracic pressure during cough merely displaces blood from the central aorta toward the periphery.The aortic valve does not open and thus blood is not "pumped" from the lungs and left heart, as suggested by Dr Cary and others.Such pumping may occur in patients undergoing cardiopulmonary resuscitation, who have very low arterial pressures.23
Use of small amounts of ultrasound guided air for injections
Authors: H BLIDDAL
Journal: Annals of the Rheumatic Diseases (2000)

The existence and detection of air in various tissues is of great importance, whether the air has emanated by a disease mechanism (for example, intra-abdominal in gastric lesions, extrapulmonary in thoracic lesions) or been applied as a diagnostic tool. The detection of the air in a diagnostic test may be performed by such different methods as stethoscopy (epidurally in the whoosh test1), or radiography (intra-articularly in arthrography2 3).

In ultrasonography the injection of ultrasound contrast agents containing air may increase the diagnostic confidence in the intravascular domain.4 5 

Atmospheric air, which is much cheaper, …
Kofi Annan describes new health fund for developing countries
Authors: P. Brown
Journal: BMJ (2001)

The United Nations' secretary general, Kofi Annan, began last week to describe the details of a planned fund to combat major diseases in developing countries.

The Global AIDS and Health Fund, first mentioned by Mr Annan last month at an African leaders' summit (5 May, p 1082), will target not only AIDS, as first suggested, but also tuberculosis and malaria. …
Abstract 384: NADH oxidase, Enox1 activity, is required for vasculogenesis in Zebrafish.
Authors: Amudhan Venkateswaran, Daniel S. Levic, David B. Melville, Konjeti R. Sekhar, Alexandra J. Walsh, Melissa C. Skala, Peter A. Crooks, Ela W. Knapik, Michael L. Freeman
Journal: Cancer Research (2013)

Abstract Establishment of an adequate vascular network is a crucial event for tumor development. Emerging research has implicated the endothelial redox state as a significant regulator of vascular growth and remodeling. ENOX1 encodes a protein that is expressed in mammalian endothelial cells and exhibits NADH oxidase activity. Recent research suggests that ENOX1 functions as a positive regulator of angiogenesis. However, direct genetic evidence supporting this hypothesis is lacking. We used a zebrafish model to directly examine the role of Enox1 during embryonic vascular development. Whole mount in situ hybridization coupled with immunocytochemistry performed on zebrafish cryosections show that enox1 message and the translated protein are expressed in heart and blood vessels during embryonic development. Furthermore, use of immunocytochemistry demonstrates that Enox1 co-localizes with vascular expression of the ETS-domain transcription factor fli in heart and intersegmental vessels. Using in vivo multiphoton microscopy, we show that morpholino-mediated knockdown of Enox1 in Zebrafish embryos increases NADH fluorescence, an expected consequence of loss of Enox1 oxidase activity. Phenotypic manifestations resulting from loss of Enox1 function in embryos include vascular defects, most notably loss of fli-eGFP and flk-eGFP (receptor kdr, VEGFR2 in mammals) expression in intersegmental vessels and a loss of blood circulation in the intersegmental vessels. Pharmacological inhibition of Enox1 activity using a novel small molecule phenocopies the defects observed following morpholino-mediated functional knockdown. Together, these results show that Enox1-mediated redox regulation is essential for vasculogenesis in vertebrates in vivo. These results, in conjunction with previous work that demonstrated that inhibition of ENOX1 radiosensitized tumor vasculature, support the hypothesis that ENOX1 represents a novel target for impairing tumor angiogenesis. Citation Format: Amudhan Venkateswaran, Daniel S. Levic, David B. Melville, Konjeti R. Sekhar, Alexandra J. Walsh, Melissa C. Skala, Peter A. Crooks, Ela W. Knapik, Michael L. Freeman. NADH oxidase, Enox1 activity, is required for vasculogenesis in Zebrafish. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 384. doi:10.1158/1538-7445.AM2013-384
Asthma outcomes: Biomarkers
Authors: Stanley J. Szefler, Sally Wenzel, Robert Brown, Serpil C. Erzurum, John V. Fahy, Robert G. Hamilton, John F. Hunt, Hirohito Kita, Andrew H. Liu, Reynold A. Panettieri, Robert P. Schleimer, Michael Minnicozzi
Journal: Journal of Allergy and Clinical Immunology (2012)
Eosinophil — Mediated immunological mechanism and inflammation in vasospastic angina — Novel coronary risk factor for coronary spasm —
Authors: Seiji Umemoto, Noriko Minamisono, Takahiro Iwami, Takahito Yonezawa, Akihisa Fujii, Takashi Fujii, Masunori Matsuzaki
Journal: Journal of the American College of Cardiology (1996)
Is a decline in estimated GFR an appropriate surrogate end point for renoprotection drug trials?
Authors: Steven J. Rosansky, Richard J. Glassock
Journal: Kidney International (2014)

Recently, the US Food and Drug Administration (FDA) and the National Kidney Foundation jointly convened a meeting of experts to examine alternative surrogate end points for randomized clinical drug trials to slow development of renal failure (renoprotection trials).1 A 30% decline and a 40% decline in glomerular filtration rate (GFR) from baseline values were suggested as new surrogate end points with the hope of finding new drugs or drug combinations to slow progression more efficiently than is possible using the current FDA-accepted surrogate end point of doubling of serum creatinine concentration from baseline levels (corresponding to a 50% decline in GFR), or the 'hard' end point of death or the development of treated end-stage renal disease (ESRD).
Traumatic rupture of the right subclavian artery
Authors: R. W. Girdwood, M. P. Holden, M. I. Ionescu
Journal: Thorax (1972)

The case report of a patient who sustained a traumatic rupture of the right subclavian artery in a motor vehicle accident is presented. The preoperative diagnosis, surgical approach, postoperative management, and indications for angiography in traumatic lesions of the thoracic aorta and great vessels are discussed. The relevant literature is reviewed.
Influence of Bacterial Endotoxins on Basophil Histamine Release Potentiation of Antigen‐ and Bacteria‐Induced Histamine Release
Authors: S. Norn, L. Bæk, C. Jensen, P. Stahl Skov, H. Permin, J. O. Jarløv, C. Koch
Journal: Allergy (1986)

The histamine-releasing capability of lipopolysaccharides (LPS) was examined in human leukocyte suspensions. LPS alone did not release histamine, but was found to enhance the histamine release caused by anti-IgE. Also the IgE-mediated histamine release caused by specific antigens (allergens or bacteria) in sensitized individuals was enhanced by LPS. The potentiating effect of LPS was observed in grass pollen and dog dander allergic patients as well as in patients sensitized to E. coli or Staph. aureus bacteria. No potentiation was obtained by exposure to unspecific allergens or bacteria to which the persons were not sensitized. Bacteria can release histamine by immunological or nonimmunological mechanisms, and only the immunological histamine release was found to be potentiated by LPS. It is speculated that endotoxins reinforce release of histamine caused by allergens in allergic patients or by bacteria in persons sensitized to these microorganisms.
Hyperhomocysteinemia and cobalamin deficiency in young Asian Indians in the United States
Authors: Ralph Carmel, Padmaja V. Mallidi, Simon Vinarskiy, Shabneet Brar, Zohreh Frouhar
Journal: American Journal of Hematology (2002)

Abstract Hyperhomocysteinemia, a risk factor for vascular disease, may be a particular problem in Asian Indians, but information is limited, especially in the U.S., despite its growing Asian population. Moreover, suggestions have been made that folate deficiency is responsible for the hyperhomocysteinemia in Indians. Therefore, we studied homocysteine status in healthy Asian Indians in the U.S. prospectively, determined the frequency of cobalamin and folate deficiency as contributors to it, and examined whether food—cobalamin absorption contributed to cobalamin deficiency. Homocysteine levels were higher in Asian Indian men than in 4 other ethnic groups ( P &lt; 0.0001); 10/39 Indian men (25.6%) were hyperhomocysteinemic. Cobalamin levels were lower in Indian men ( P = 0.000005) and women ( P = 0.03) than in non‐Indians; low levels were found more frequently in both Indian men (23/39; 59.0%) and women (5/21; 23.8%) than in others. Measuring methylmalonic acid in 10 selected subjects showed that the low cobalamin levels reflected cobalamin deficiency, and high methylmalonic acid levels were found in some subjects without hyperhomocysteinemia. Evidence of folate deficiency was not found in any subjects. Food–cobalamin absorption was normal in all 13 Indian subjects tested, including those with Helicobacter pylori infection. The results show that hyperhomocysteinemia is strikingly common in apparently healthy, young Asian Indian men. The cause appears to be cobalamin deficiency, which affected more than half of the Indian men, may be largely subclinical, is underestimated by homocysteine levels alone which were not always abnormal, and is probably largely dietary in origin. Folate deficiency is rare. This public health problem is amenable to prevention and treatment in this growing segment of the U.S. population. It was, parenthetically, noteworthy that many of the affected subjects were young physician trainees. Am. J. Hematol. 70:107–114, 2002. © 2002 Wiley‐Liss, Inc.