tbuckley/cabot-search huggingface dataset:
Thyroid Disease and Alkaline Phosphatase
Authors: DAVID V. HAMILTON
Journal: Annals of Internal Medicine (1979)

Letters and Corrections1 March 1979Thyroid Disease and Alkaline PhosphataseDAVID V. HAMILTON, M.B., B. CHIR.DAVID V. HAMILTON, M.B., B. CHIR.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-3-440 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Following the recent reports in your journal of raised alkaline phosphatase levels in patients with subacute thyroiditis (1-4), I wish to report an additional case in which initial liver function test findings were normal. I also wish to report a case of thyrotoxicosis in which liver function test findings have remained abnormal for 9 months.A 38-year-old woman presented with a 2-week history of painful swelling of her thyroid gland, which on examination was tender. Investigations (see Table 1) were essentially normal apart from an elevated erythrocyte sedimentation rate and serum thyroxine. She was treated with indomethacin....References1. DALOVISIOBLONDECORTEZPANKEY JLLG: Subacute thyroiditis with increased serum alkaline phosphatase. Ann Intern Med 88:505-507, 1978 LinkGoogle Scholar2. FENNELL J: Alkaline phosphatase and thyroiditis (letter). Ann Intern Med 89:143, 1978 LinkGoogle Scholar3. LEWIS D: Alkaline phosphatase and thyroiditis (letter). Ann Intern Med 89:143-144, 1978 LinkGoogle Scholar4. KASPANAPARSTEK RY: Thyroiditis and alkaline phosphatase (letter). Ann Intern Med 89:578, 1978 LinkGoogle Scholar5. DOONERPARADAALIAGAHOYL HJCC. The liver in thyrotoxicosis. Arch Intern Med 120:25-32, 1967 CrossrefMedlineGoogle Scholar1. DALOVISIOBLONDECORTEZPANKEY JLLG: Subacute thyroiditis with increased serum alkaline phosphatase. Ann Intern Med 88:505-507, 1978 LinkGoogle Scholar2. FENNEL J: Alkaline phosphatase and thyroiditis (letter) Ann Intern Med 89:143, 1978 LinkGoogle Scholar3. LEWIS D: Alkaline phosphatase and thyroiditis (letter). Ann Intern Med 89:143-144, 1978 LinkGoogle Scholar4. WALLACH J: Interpretation of Diagnostic Tests, 3rd ed. Boston, Little, Brown & Co., 1978, p. 53 Google Scholar5. VOLPÉROWEZRIN RVC: Circulating viral and thyroid antibodies in subacute thyroiditis. J Clin Endocrinol 27:1275-1284, 1967 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPainless giant cell thyroiditisOCCULT SUBACUTE THYROIDITIS WITH UNUSUAL FEATURESPersistent vocal cord paralysis in subacute thyroiditisThyroiditis and Alkaline PhosphataseF. PEREZ-JIMENEZ, M.D., J. A. JIMENEZ PEREPEREZ, M.D., J. RIVERA, M.D., R. MUÑOZ, M.D. 1 March 1979Volume 90, Issue 3Page: 440-441KeywordsErythrocyte sedimentation rateInflammationLiver function testsPhosphatasesThyroidThyroid diseasesThyroxine ePublished: 1 December 2008 Issue Published: 1 March 1979 PDF downloadLoading ...
Neurosurgical Management of the Epilepsies
Authors: John E. Adams
Journal: JAMA (1976)

This is an authoritative review of the current status of surgical treatment of all the epilepsies. The participants come chiefly from the four major centers where this highly specialized type of neurosurgical endeavor is being done, namely, the Montreal Neurological Institute, the Surgical Neurology Branch of the National Institute of Neurological Disease and Stroke at the National Institutes of Health, the Department of Neurological Surgery at the University of Washington in Seattle, and finally, a similar department at the University of California at Los Angeles. The historical background is reviewed by one of the pioneers in this form of surgical treatment. The whole subject is covered in depth. The chapter by Arthur Ward, Jr, includes the most recent information available as to the nature of the "epileptic focus." It is, of course, an a priori fact that the existence of such a "focus" is the very basis for the surgical
A Clonal Complete Remission in a Patient with Acute Nonlymphocytic Leukemia Originating in a Multipotent Stem Cell
Authors: Robert J. Jacobson, Matthew J. Temple, Jack W. Singer, Wendy Raskind, Jerry Powell, Philip J. Fialkow
Journal: New England Journal of Medicine (1984)

REMISSION after cytotoxic therapy in acute nonlymphocytic leukemia is thought to result from selective destruction of leukemic cells and repopulation of the marrow by normal stem cells. This postulate is supported by the restoration of a normal karyotype in marrow cells and cultured myeloid colonies after chemotherapy.1 2 3 In addition, in five patients with acute nonlymphocytic leukemia who were heterozygous for glucose-6-phosphate dehydrogenase, only a single enzyme type was found in the leukemic blast cells on initial presentation, but when the patients entered clinical remission, a normal double-enzyme phenotype was observed in mature granulocytes and their precursors.4 5 6 These findings indicated that . . .
Traveller's thrombosis
Authors: P. Kesteven
Journal: Thorax (2000)

Purkinje cells are among the most resistant neurons to axotomy and the most refractory to axonal regeneration. By using organotypic cultures, we have studied age- and environment-related factors implicated in Purkinje cell survival and axonal regeneration. Most Purkinje cells taken from 1- to 5-d-old rats, the period in which these neurons are engaged in intense synaptogenesis and dendritic remodeling, die 1 week after plating, whereas if cultured before or after this period, Purkinje cells survive, even in the absence of deep nuclear neurons, their postsynaptic targets. Cerebellar slices taken from 10-d-old rats and kept <i>in vitro</i> for 1 week acquire a cellular composition resembling mature cerebellum. Their Purkinje cells are resistant to axotomy, but even when confronted with permissive environments (sciatic nerves or fetal cerebellar slices), their axons do not regenerate. In contrast, fetal rat and mouse Purkinje cells are able to regenerate their axons on mature cerebellar slices. This regeneration is massive, and the regrowing axons invade all cerebellar regions of the apposed mature slices, including white matter. These results show that Purkinje cell survival and axonal regeneration are age-related and independent from environmental constraints. Moreover, our observations suggest strongly that the onset of synaptogenesis of Purkinje cell axons could provide a signal to turn off their growth program and that, thereafter, permissive microenvironment alone is unable to reestablish such a program.
Studies in the behavioral toxicology of environmental contaminants.
Authors: B Weiss, T E Levine
Journal: Environmental Health Perspectives (1976)

Behavioral toxicology represents a relatively new research area in the West, and a new source of information pertinent to standard setting. Despite this abbreviated history, however, it can call on a rather advanced technology, largely provided by the rapid and extensive development of behavioral pharmacology during the past two decades. As exemplified by the U.S. contribution to the joint study of carbon disulfide, the approach derived from this background relies on the acquisition of dose--effect data with a preparation yielding stable baseline performance. The first study in this collaborative series employed pigeons trained to peck a response device consisting of a transilluminnated plastic disk. Various relationships between this response and the occasions on which it led to the delivery of food were explored in order to ascertain which behavioral variables were most sensitive to acute exposures. In addition, a central nervous system drug, whose neurochemical mode of action is believed to parallel that of carbon disulfide, was tested in the same preparations. Further research on these questions is being continued with monkeys.
Therapeutic Effects of Hyoscyamine
Authors: T. Browne
Journal: BMJ (1882)

have a syphilitic basis; and, if I am correct in the view that the cere- bral lesion is multiple, it is a ftrther corroboration of the syphilitic theory, as we know that syphilitic lesions of the nervous system are often multiple.At all events, we shall pat him fully under the influ- ence of mercury by rubbing a drachm of strong mercurial ointment into some soft part of the skin daily; and we shall watch the effects with much interest.But, even should the result be negative, it will by no means prove that the lesion is not primariW syphilitic; for while, by means of mercury, we can dissipate existing syphilitic manifestions, we cannot expect to influence the secondary non-syphilitic changes which axe apt to ensue in the surrounding tissues..[SEQUEL OF THE CASE.-The treatment, was commenced upon J.Ulnuary 29th, I882, and was continued for ten days (one ounce and ,two dranchms of mercurial ointment having been used in that time), ht i(as suspended, owing to the gumus being slightly affected.On Nebixuar* soth, three days -after the mercurial treatment was stopped, an examination of the patient was made.lHe told us that the fulness and discomfort in the head, of whi .h. .complained,had entirel dis- appeared, and altogether he felt quite a different:.man.The.unilateral
Metastatic tumour of right atrium mimicking constrictive pericarditis and tricuspid stenosis.
Authors: K M De Cock, D K Gikonyo, S B Lucas, J B Were
Journal: BMJ (1982)

Metastatic tumour of right atrium mimicking constrictive pericarditis and tricuspid stenosisThough secondary cardiac tumours are 20 times more common than primary lesions,' and cardiac metastases are found in up to 19% of necropsies undertaken on patients who have died of cancer,2 correct diagnosis of secondary spread to the heart is rare.We describe a patient in whom an unrecognised right atrial metastasis was clinically mistaken for constrictive pericarditis while results of cardiac catheterisation suggested tricuspid stenosis.Case report
Protumoral role of monocytes in human B-cell precursor acute lymphoblastic leukemia: involvement of the chemokine CXCL10
Authors: Yunqin Lee, Manesh Chittezhath, Valentina André, Helen Zhao, Michael Poidinger, Andrea Biondi, Giovanna D'Amico, Subhra K. Biswas
Journal: Blood (2011)
Continuous Recording of Direct Arterial Pressure and Electrocardiogram in Unrestricted Man
Authors: W. A. Littler, A. J. Honour, P. Sleight, F. D. Stott
Journal: BMJ (1972)

A system has been devised which records direct arterial pressure, electrocardiogram, and other variables in man with no restriction of activity. The advantage of this system is that the record is on magnetic tape, and it is possible to replay the records at various speeds to analyse each beat or to produce an entire 24-hour record on a few feet of paper. A marker allows the timing of relevant events. Initial experience with this procedure indicates that is is safe and reliable.
Decreased insulin response to glucose in islet cell antibody-negative siblings of type 1 diabetic children.
Authors: J C Carel, C Boitard, P F Bougnères
Journal: Journal of Clinical Investigation (1993)

Measurement of beta-cell function is an important marker of progression to diabetes in individuals at risk for the disease. Although the peak incidence for the disease occurs before 17 years of age, normal values for insulin secretion were not available in this age group. We performed a simplified intravenous glucose tolerance test in 167 normal children, and in 98 islet cell antibody (ICA)-negative and 12 ICA-positive siblings of diabetic patients. Their age range was 1-16 yr. The first phase of insulin secretion, evaluated as the sum of plasma insulin concentrations at 1 and 3 min, increased with age and was significantly lower in ICA-negative siblings (86 +/- 6 microU/ml, P < 0.002) than in normal controls (115 +/- 6 microU/ml). This difference was not apparent before 8 yr of age. None of the ICA-negative siblings developed diabetes after an average of 4.5 yr. ICA-positive siblings at first study had a first phase insulin response similar to that of ICA negative siblings, but significantly lower than that of the normal controls (74 +/- 13 microU/ml, P < 0.02). The reason for the decreased insulin secretion in ICA-negative siblings is unknown, but could involve a defect in the growth of beta-cell mass or insulin secretion that could be part of the multifactorial pathogenesis of type 1 diabetes.
Enhancement of DNA Vaccine Potency by Coadministration of a Tumor Antigen Gene and DNA Encoding Serine Protease Inhibitor-6
Authors: Tae Woo Kim, Chien-Fu Hung, David A. K. Boyd, Liangmei He, Cheng-Tao Lin, Dion Kaiserman, Phillip I. Bird, T-C. Wu
Journal: Cancer Research (2004)

Serine protease inhibitor 6 (SPI-6), also called Serpinb9, inhibits granzyme B and thus may provide a method for delaying apoptotic cell death in dendritic cells. We have previously enhanced DNA vaccine potency by targeting antigen to MHC antigen presentation pathways, using proteins such as Mycobacterium tuberculosis heat shock protein 70, calreticulin, domain II of Pseudomonas aeruginosa exotoxin A, or the sorting signal of the lysosome-associated membrane protein type 1. In this study, we explored intradermal coadministration of DNA encoding SPI-6 with DNA constructs encoding human papillomavirus type 16 E7 linked to these intracellular targeting molecules for its ability to generate E7-specific CD8+ T-cell immune responses and E7-specific antitumor effects. This combination of strategies resulted in significantly increased E7-specific CD8+ T-cell and CD4+ Th1-cell responses, enhanced tumor treatment ability, and stronger tumor protection when compared with vaccination without SPI-6. Among these targeting strategies tested, mice vaccinated with Sig/E7/lysosome-associated membrane protein type 1 mixed with SPI-6 showed the greatest fold increase in E7-specific CD8+ T cells ( approximately 5-fold). Vaccination with a nonfunctional mutant of SPI-6 did not result in immune enhancement, indicating that enhancement was dependent on the antiapoptotic function of SPI-6. Our results suggest that DNA vaccines combining strategies that enhance MHC class I and II antigen processing with SPI-6 have potential clinical implications for control of viral infection and neoplasia.
Cellular senescence of white blood cells in very long-term survivors after allogeneic hematopoietic stem cell transplantation: the role of chronic graft-versus-host disease and female donor sex
Authors: Gabriela M. Baerlocher, Alicia Rovó, Astrid Müller, Sybille Matthey, Martin Stern, Jörg Halter, Dominik Heim, Johannes Rischewski, Alois Gratwohl, André Tichelli
Journal: Blood (2009)
ETHER ANÆSTHESIA.Read before the Kings County Medical Association, February 9, 1892.
Authors: J. D. RUSHMORE
Journal: JAMA (1892)

<i>Mr. President and Members of the Kings County Medical Association:</i>—It is provided by the by-laws of this Association that "at the February meeting each year the nine o'clock hour shall be devoted to an address from the president of the preceding year, upon the progress made during the year in that branch of the medical art or science in which he may have been specially interested." It is therefore in accordance with a free interpretation of the above by-law that a paper is presented for your consideration on the subject of ether anaesthesia, which may properly be classed among the medical arts; but, if I confined myself to the strict letter of the law, it is quite certain that I shall fail to present anything that can properly be considered to represent progress made during the year. It is not always certain at the close of a year what progress
Lichen planus and hepatitis C virus: prevalence and clinical presentation of patients with lichen planus and hepatitis C virus infection
Authors: J. SÁNCHEZ-PÉREZ, M. DE CASTRO, G.F. BUEZO, J. FERNANDEZ HERRERA, M.J. BORQUE, A. GARCÍA-DIEZ
Journal: British Journal of Dermatology (1996)

Although cases of lichen planus (LP) associated with hepatitis C virus (HCV) infection have been described, the association between the two diseases has not been established because the geographic origin of patients could be an important factor in HCV prevalence in patients with LP. The serum samples of 78 consecutive patients with cutaneous and/or mucous LP and 82 control patients were analysed for the presence of antibodies to HCV by enzyme-immunoassay and for the presence of antigens of HCV by two-stage polymerase chain reaction (PCR). The clinical features of patients with LP associated with HCV infection were compared with patients with LP without HCV infection. Sixteen of the 78 (20%) patients had anti-HCV antibodies. In 13 of these 16 cases (81%), HCV-RNA was detected by PCR in serum samples. In the 82 control patients, anti-HCV antibodies was observed in two (2.4%) patients. We have found a statistically significant association (P < 0.05) between erosive LP and HCV infection. We conclude that the high prevalence of HCV-RNA in patients with LP provides some evidence for the role of HCV in the pathogenesis of LP. Our results suggest an association between erosive LP and HCV infection.
The Pressor Response to Water Drinking in Humans
Authors: Jens Jordan, John R. Shannon, Bonnie K. Black, Yasmine Ali, Mary Farley, Fernando Costa, Andre Diedrich, Rose Marie Robertson, Italo Biaggioni, David Robertson
Journal: Circulation (2000)

Background —Water drinking increases blood pressure profoundly in patients with autonomic failure and substantially in older control subjects. The mechanism that mediates this response is not known. Methods and Results —We studied the effect of drinking tap water on seated blood pressure in 47 patients with severe autonomic failure (28 multiple system atrophy [MSA], 19 pure autonomic failure patients [PAF]). Eleven older controls and 8 young controls served as control group. We also studied the mechanisms that could increase blood pressure with water drinking. Systolic blood pressure increased profoundly with water drinking, reaching a maximum of 33±5 mm Hg in MSA and 37±7 in PAF mm Hg after 30 to 35 minutes. The pressor response was greater in patients with more retained sympathetic function and was almost completely abolished by trimethaphan infusion. Systolic blood pressure increased by 11±2.4 mm Hg in elderly but not in young controls. Plasma norepinephrine increased in both groups. Plasma renin activity, vasopressin, and blood volume did not change in any group. Conclusions —Water drinking significantly and rapidly raises sympathetic activity. Indeed, it raises plasma norepinephrine as much as such classic sympathetic stimuli as caffeine and nicotine. This effect profoundly increases blood pressure in autonomic failure patients, and this effect can be exploited to improve symptoms due to orthostatic hypotension. Water drinking also acutely raises blood pressure in older normal subjects. The pressor effect of oral water is an important yet unrecognized confounding factor in clinical studies of pressor agents and antihypertensive medications.
What is the link between propositions and memories?
Authors: Ben R. Newell
Journal: Behavioral and Brain Sciences (2009)

Abstract Mitchell et al. present a lucid and provocative challenge to the claim that links between mental representations are formed automatically. However, the propositional approach they offer requires clearer specification, especially with regard to how propositions and memories interact. A definition of a system would also clarify the debate, as might an alternative technique for assessing task “dissociations.”
Significant and persistent improvement of thrombocytopenia after splenectomy in an adult with the wiskott‐aldrich syndrome and intra‐cerebral bleeding
Authors: Jean‐Michel Gaspoz, Francis Waldvogel, Pierre Cornu, Edouard Gugler, Jean‐Michel Dayer
Journal: American Journal of Hematology (1995)

Abstract The Wiskott‐Aldrich syndrome is an X‐linked inherited immunodeficiency disorder characterized by thrombocytopenia, recurrent infections and eczema. Its best management option is HLA‐ldentical bone marrow transplantation; when this is not feasible, splenectomy, followed by continuous prophylactic antibiotics, represents the alternative of choice. The present case report relates the excellent outcome of an adult with the Wiskott‐Aldrich syndrome who suffered his first major complication of the disease at age 33 years, an intracerebral hemorrhage. Since an uneventfull splenectomy, thrombocytopenia has significantly improved, and he has remained free of infections for a follow‐up period of 3 years while being treated with prophylactic antibiotics. ©1995 Wiley‐Liss, Inc.
Pericardial Coelomic Cysts
Authors: B. T. Le Roux
Journal: Thorax (1959)

Thin-walled cysts containing clear liquid are occasionally found in the anterior cardiophrenic angle.They are believed to develop in conjunction with the pericardium and are now generally called pericardial coelomic cysts.In this paper 20 cases of such cysts are described (Table I) and the relevant literature is discussed.Of these 20 patients, 12 were men and eight were women.The youngest patient was 17 years and the oldest 69.Thirteen of the cysts were in the right cardiophrenic angle and six in the left.In one patient the opacity was visible on both sides of the cardiac shadow, but was larger on the right and was approached for removal through a right thoracotomy.-6,, 1 Protein, 290 mg.°/ Chloride, 640,,
Use of Amantadine in Parkinson's Disease. Results of a Double-blind Trial
Authors: V. Dallos, K. Heathfield, P. Stone, F. A. D. Allen
Journal: BMJ (1970)

<h3>Abstract</h3> Movement-related neuronal discharge in ventral tegmental area (VTA) and ventral pallidum (VP) is inconsistently observed across studies. One possibility is that some neurons are movement-related and others are not. Another possibility is that the precise behavioral conditions matter - that a single neuron can be movement related under certain behavioral states but not others. We recorded single VTA and VP neurons in birds transitioning between singing and non-singing states, while monitoring body movement with microdrive-mounted accelerometers. Many VP and VTA neurons exhibited body movement-locked activity exclusively when the bird was not singing. During singing, VP and VTA neurons could switch off their tuning to body movement and become instead precisely time-locked to specific song syllables. These changes in neuronal tuning occurred rapidly at state boundaries. Our findings show that movement-related activity in limbic circuits can be gated by behavioral context. <h3>Significance statement</h3> Neural signals in the limbic system have long been known to represent body movements as well as reward. Here we show that single neurons dramatically change their tuning to movements when a bird starts to sing.
Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model.
Authors: D M Shih, L Gu, S Hama, Y R Xia, M Navab, A M Fogelman, A J Lusis
Journal: Journal of Clinical Investigation (1996)

In an effort to identify genetic factors contributing to atherogenesis, we have studied inbred strains of mice that are susceptible (C57BL/6J) and resistant (C3H/HeJ) to diet-induced aortic fatty streak lesions. When maintained on a low-fat diet, HDL isolated from both strain C57BL/6J (B6) and C3H/HeJ (C3H) mice protect against LDL oxidation in a coculture model of the artery wall. However, when maintained on an atherogenic diet high in fat and cholesterol, the HDL isolated from B6 mice lose the capacity to protect, whereas HDL from C3H mice protect equally well. Associated with the loss in the ability of HDL to protect is a decrease in the activity of serum paraoxonase, a serum esterase carried on HDL that has previously been shown to protect against LDL oxidation in vitro. The levels of paraoxonase mRNA decreased in B6 mice upon challenge with the atherogenic diet but increased in C3H, indicating that paraoxonase production is under genetic control. In a set of recombinant inbred strains derived from the B6 and C3H parental strains, low paraoxonase mRNA levels segregated with aortic lesion development, supporting a role for paraoxonase in atherogenesis.