tbuckley/cabot-search huggingface dataset:
IS NEPHRECTOMY ALWAYS INDICATED FOLLOWING A DIAGNOSIS OF UNILATERAL RENAL TUBERCULOSIS?
Authors: STANLEY R. WOODRUFF
Journal: JAMA (1935)

The possibility that renal tuberculosis, once it has reached the point at which diagnosis is beyond question, ever heals has received considerable discussion during the last fifteen years. In 1920 Chute1reviewed three cases that occurred in his practice; he considered that there were indications in occasional cases that tuberculous processes of the kidney healed. He pointed out how such a belief is necessary if one is to accept the hypothesis of the hematogenous route of the infection. He says:  I believe we must assume that tubercle bacilli are brought in approximately equal numbers to both kidneys, that small cortical tuberculous infections are common and that far from going on to complete destruction of every kidney that is infected they are probably promptly stamped out in the greater majority of instances. The generous blood supply of the kidney allows it to overcome perhaps the greater number of infections while
GP73, a resident Golgi glycoprotein, is a novel serum marker for hepatocellular carcinoma
Authors: Jorge A. Marrero, Patrick R. Romano, Olga Nikolaeva, Laura Steel, Anand Mehta, Claus J. Fimmel, Mary Ann Comunale, Anthony D'Amelio, Anna S. Lok, Timothy M. Block
Journal: Journal of Hepatology (2005)
Primary amyloidosis and myelomatosis associated with excessive fibrinolytic activity
Authors: L.G. MILLARD, N.R. ROWELL
Journal: British Journal of Dermatology (1976)

Journal Article Primary amyloidosis and myelomatosis associated with excessive fibrinolytic activity Get access L.G. MILLARD, L.G. MILLARD Department of Dermatology, The General Infirmary, Leeds LS1 3EX Search for other works by this author on: Oxford Academic Google Scholar N.R. ROWELL N.R. ROWELL Department of Dermatology, The General Infirmary, Leeds LS1 3EX Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 94, Issue 5, 1 May 1976, Pages 569–571, https://doi.org/10.1111/j.1365-2133.1976.tb05148.x Published: 01 May 1976
Food, functional food
Authors: Douglas Kamerow
Journal: BMJ (2004)

Where do foods leave off and medicines begin?

As functional foods become more popular, it's hard to know. The Japanese coined the term functional foods almost 20 years ago to define foods having ingredients (in addition to their basic nutritional content) that prevent or treat disease. They can be plant-based foods (think of oats and cholesterol or cranberry juice and urinary tract infections) or products from animals (oily fish and heart disease).

Two clinical reviews in this issue address functional foods. Jehangir Din …
Can interferon-ribavirin effectively treat patients who did not respond to a first conventional therapy by interferon ?
Authors: S. Marchi, P. Ciccorossi, S. Petruccelli, A. Ricchiuti, P. Arpe, P. Da Massa Carrara, F. Costa, M. Bellini, F. Maggi, M.L. Vatteroni, M. Bendinelli, G. Maltinti
Journal: Journal of Hepatology (1998)
The Old Man
Authors: Howard J. Bennett
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chronic Hepatitis C Virus Infection
Authors: Steven L. Flamm
Journal: JAMA (2003)

CHRONIC HEPATITIS C VIRUS (HCV) infection is a common worldwide problem. The infection may progress to cirrhosis with the subsequent development of complications such as ascites, encephalopathy, variceal bleeding, and hepatocellular carcinoma. Thus, early detection and therapy is of great importance. There has been substantial progress in understanding various aspects of HCV infection, including the virology, epidemiology, natural history of chronic infection, and medical therapy. The objective of this article is to provide relevant clinical information regarding the contemporary approach to patients with chronic HCV infection.
Is the emergency (999) service being misused? retrospective analysis
Authors: C. Mann, H. Guly
Journal: BMJ (1998)

The number of emergency admissions to hospitals in the United Kingdom has increased for reasons that are not fully understood. The increase can be traced back to the early 1980s and is not simply the result of organisational changes in the NHS.1 The ageing population is not the principal factor as demographic changes between 1981 and 1994 account for only 5.6% of the total increase in emergency admissions, and the increase has occurred in all age groups. More important is the increase in the proportion of patients admitted several times over a five year period: this number rose by 92% between 1981–5 and 1990-4.1

Other causes cited for the increase in emergency admissions include higher patient expectations and a rise in referrals from general practitioners.2 …
Gemcitabine Sensitivity Can Be Induced in Pancreatic Cancer Cells through Modulation of miR-200 and miR-21 Expression by Curcumin or Its Analogue CDF
Authors: Shadan Ali, Aamir Ahmad, Sanjeev Banerjee, Subhash Padhye, Kristin Dominiak, Jacqueline M. Schaffert, Zhiwei Wang, Philip A. Philip, Fazlul H. Sarkar
Journal: Cancer Research (2010)

Curcumin induces cancer cell growth arrest and apoptosis in vitro, but its poor bioavailability in vivo limits its antitumor efficacy. We have previously evaluated the bioavailability of novel analogues of curcumin compared with curcumin, and we found that the analogue CDF exhibited greater systemic and pancreatic tissue bioavailability. In this study, we evaluated the effects of CDF or curcumin alone or in combination with gemcitabine on cell viability and apoptosis in gemcitabine-sensitive and gemcitabine-resistant pancreatic cancer (PC) cell lines. Mechanistic investigations revealed a significant reduction in cell viability in CDF-treated cells compared with curcumin-treated cells, which were also associated with the induction of apoptosis, and these results were consistent with the downregulation of Akt, cyclooxygenase-2, prostaglandin E(2), vascular endothelial growth factor, and NF-kappaB DNA binding activity. We have also documented attenuated expression of miR-200 and increased expression of miR-21 (a signature of tumor aggressiveness) in gemcitabine-resistant cells relative to gemcitabine-sensitive cells. Interestingly, CDF treatment upregulated miR-200 expression and downregulated the expression of miR-21, and the downregulation of miR-21 resulted in the induction of PTEN. These results prompt further interest in CDF as a drug modality to improve treatment outcome of patients diagnosed with PC as a result of its greater bioavailability in pancreatic tissue.
Early estimates of seasonal influenza vaccine effectiveness in Europe: results from the I-MOVE multicentre case–control study, 2012/13
Authors: M Valenciano, E Kissling, Collective I-MOVE case–control study team
Journal: Eurosurveillance (2013)

We conducted a test-negative case-control study based in five European sentinel surveillance networks. The early 2012/13 adjusted influenza vaccine effectiveness was 78.2% (95% CI: 18.0 to 94.2) against influenza B, 62.1% (95% CI: -22.9 to 88.3%) against A(H1) pdm09, 41.9 (95% CI: -67.1 to 79.8) against A(H3N2) and 50.4% (95% CI: -20.7 to 79.6) against all influenza types in the target groups for vaccination. Efforts to improve influenza vaccines should continue to better protect those at risk of severe illness or complications.
Self-poisoning with Drugs: A Worsening Situation
Authors: A. J. Smith
Journal: BMJ (1972)

The incidence of self-poisoning with drugs has doubled in Sheffield in the past 10 years. It now causes almost 1 in 10 of all medical admissions and one in five of all medical emergencies; it is the second most common reason for emergency admission to medical beds.The average age of the patients has fallen; one in five has previously been admitted to hospital with self-poisoning. The drugs used are normally prescribed by a doctor and the types employed reflect national prescribing trends. It is estimated that over 70,000 self-poisoning cases may be admitted to hospitals in the United Kingdom each year.
People travelling abroad issued advice on bird flu
Authors: Michael Day
Journal: BMJ (2006)

England has joined other European countries in advising people on how to avoid the H5N1 strain of avian influenza, as the virus continues its spread eastwards.

Liam Donaldson, the chief medical officer for England, said that although H5N1 infections had not yet been reported in the UK it was “important that travellers from the UK have clear factual information to assist them.” A leaflet made available last week in general practices, health centres, and air and sea ports in England tells people travelling abroad not to visit bird or poultry farms and markets, to avoid close contact with live or dead poultry, not …
TELETHONIN MUTATIONS ASSOCIATED WITH BRUGADA SYNDROME REDUCE CARDIAC SODIUM CURRENTS
Authors: Isik Turker, Takeru Makiyama, Takeshi Ueyama, Wataru Shimizu, Minoru Horie, Matteo Watta, Peng-Sheng Chen, Tomohiko Ai
Journal: Journal of the American College of Cardiology (2012)
THE CONTROL OF INTRACRANIAL PRESSURE
Authors: TEMPLE FAY
Journal: JAMA (1925)

Because of the many inquiries regarding the method of administration of magnesium sulphate that I<sup>1</sup>have employed in cases of increased intracranial pressure, an outline of treatment, based on four years of experience and observation at the University Hospital, is offered in the management of such cases. Magnesium sulphate, if properly administered, will definitely reduce intracranial pressure within a few hours. Reduction of pressure may be maintained by its repeated use over a period of weeks. Acute pressure phases seen in traumatic head injuries can be adequately combated so that decompression for pressure has been found unnecessary in this hospital for the last three years. Magnesium sulphate is given as a routine in all intracranial injuries, with the exceptions noted below. Results have shown that the reduction of brain volume is greater and more satisfactory than the limited possibility offered by subtemporal decompression for pressure, and obviates the necessity
Diseases of the skin. Structure and function of skin in relation to therapy.
Authors: J A Hunter
Journal: BMJ (1973)

Traditionally dermatological therapy has been associated with a degree of mystery and an unenviable number of well-worn cliches.This series aims to outline an up-to-date and rational approach to the treatment of common skin disorders.The first article will describe the structure and function of normal skin, as a knowledge of these is needed to understand the mechan- isms of disease and the effects of drug action.The second introductory article will deal with more practical problems of prescribing. AnatomyThe diagram opposite represents normal skin.It varies in thickness from about 3 to 5 mm and consists of three main layers: a stratified squamous epithelium called the epidermis, a connective-tissue dermis, and an underlying fatty layer.The normal function of each depends on the integrity of the others. EPIDERMISThe prickle cell layer consists of keratinocytes produced by cells dividing in the basal and suprabasal layers.Keratinocytes contain bundles of fibrous protein (tonofibrils) and are connected with one another by numerous disc-shaped structures in the cell wall called desmosomes.With the electron microscope
Toxicology and Occupational Medicine
Authors: Asher J. Finkel
Journal: JAMA (1980)

This volume is a collection of reports presented at the Tenth Inter-American Conference on Toxicology and Occupational Medicine held in Miami on Oct 22-25, 1978. The contributions cover a wide variety of topics ranging from carcinogenicity and mutagenicity to ciguatera poisoning. The bulk of the reports deal with toxic and metabolic aspects of pesticides and other chemical environmental pollutants. There is no consistent theme that characterizes the various reports, although many are of considerable intrinsic interest. The title is slightly misleading, for only ten of the 46 essays deal with occupational medicine, and as noted, the main emphasis of the conference was largely toxicological in nature.
Hepatic lipid profiling in chronic hepatitis C: An in vitro and in vivo proton magnetic resonance spectroscopy study
Authors: Jeremy F.L. Cobbold, Jaymin H. Patel, Robert D. Goldin, Bernard V. North, Mary M.E. Crossey, Julie Fitzpatrick, Marzena Wylezinska, Howard C. Thomas, I. Jane Cox, Simon D. Taylor-Robinson
Journal: Journal of Hepatology (2009)
FDA panel rejects testosterone patch for women on safety grounds
Authors: Ray Moynihan
Journal: BMJ (2004)

A panel of advisers to the US Food and Drug Administration last week unanimously rejected an experimental testosterone patch as a treatment for women with sexual difficulties.

Procter & Gamble, global manufacturer of household products, wants to market the patch to women who have become menopausal after ovarian surgery, are currently taking oestrogen, and are said to have a controversial condition—“hypoactive sexual desire disorder.”

The FDA had granted Procter & Gamble a fast track review of the testosterone patch, but the committee's unanimous …
Valvular heart disease in four patients with Maroteaux-Lamy syndrome.
Authors: C T Tan, H V Schaff, F A Miller, W D Edwards, P S Karnes
Journal: Circulation (1992)

BACKGROUND Maroteaux-Lamy syndrome is a lysosomal storage disease of mucopolysaccharide metabolism (MPS type VI) that may involve the mitral and aortic valves. Affected patients have other skeletal and oropharyngeal malformations that complicate anesthetic and surgical management. METHODS AND RESULTS The present report describes the clinical, echocardiographic, and pathological findings in four patients with Maroteaux-Lamy syndrome. Two of three siblings underwent successful double-valve replacement for aortic and mitral valve stenoses. The third sibling, whose aortic and mitral valves were thick and fibrotic, died from septicemia after hip surgery. A fourth, unrelated patient also had successful double-valve replacement. CONCLUSIONS Our experience emphasizes the potential difficulties in preoperative assessment and surgical treatment as well as the unique problems related to airway management in patients with this syndrome.
Doctors and Clergy — Women Graduates
Authors: John Lister
Journal: New England Journal of Medicine (1954)

A patient with anxiety symptoms came to my clinic a few weeks back, and I asked her whether the tablets I had prescribed (barbiturates) were doing her any good. She answered with some hesitation that she thought they had helped her and then added quickly, "But they've not done me as much good as Dr. Billy Graham." I have no doubt that she was quite right.The importance of the spiritual element in a properly integrated physical and mental life has recently been stressed in a number of letters to the British Medical Journal. The correspondence was opened by . . .
The synergistic effect of hierarchical micro/nano-topography and bioactive ions for enhanced osseointegration
Authors: Wenjie Zhang, Guocheng Wang, Yan Liu, Xiaobing Zhao, Duohong Zou, Chao Zhu, Yuqin Jin, Qingfeng Huang, Jian Sun, Xuanyong Liu, Xinquan Jiang, Hala Zreiqat
Journal: Biomaterials (2013)
Clinical use of nicotine chewing-gum.
Authors: M A Russell, M Raw, M J Jarvis
Journal: BMJ (1980)

Nicotine chewing-gum has recently become available to doctors in Britain for use as an aid to giving up smoking. It produces blood nicotine concentrations similar to tobacco smoking and so relieves symptoms of nicotine withdrawal. Owing partly to the slower rate of absorption of nicotine through the buccal mucosa, however, it does not reproduce the pleasure of cigarette smoking. Indeed, in the early stages it is usually slightly aversive. Optimal use in a skill requiring practice and careful instruction. Since it is an aid rather than easy cure, its use is limited to smokers who want to stop. Earlier trials showed modest advantages over placebo, but improvements in the gum and more experience in its use suggest that long-term success rates of 40% or more can be obtained. It required little time to administer and is therefore a feasible method for busy doctors.
Firm, patient, and process variables associated with length of stay in four diseases
Authors: L C. Fernow, I McColl, C. Mackie
Journal: BMJ (1978)

Factors associated with length of stay in three London teaching hospitals during 1972 and 1975 were examined in patients treated for myocardial infarction, cerebrovascular disease, inguinal hernia without obstruction, and gall stones. Statistical analyses were carried out with multiple regressions on log lengths of stay.Increased length of stay was associated with infection in all four groups and with the seriousness of operative procedures in all but patients with cerebrovascular disease. Although age was a significant variable in patients with hernias and gall stones, it had relatively little practical effect on length of stay. Other significant variables in at least one disease were obesity, number of abnormalities in blood chemistry, administration of parenteral fluids or oxygen, or use of monitoring devices, and whether chest radiography was carried out, blood electrolytes and urea were measured, or anticoagulants were used. Patients with cerebrovascular disease who were not discharged to their own homes stayed on average more than two and a half times longer than other patients.Between a third and a half of the variance was explained by these variables and the variation among firms. The method described is reproducible in other hospital settings, and the study shows that much new information could be available routinely without mounting expensive field trials.
EXPERIMENTAL MUMPS MENINGITIS
Authors: Martha Wollstein
Journal: The Journal of Experimental Medicine (1921)

It has been shown that an aseptic meningitis of 3 to 5 days duration and favorable prognosis can be induced in cats by intrathecal injection of sterile saliva filtrate from early cases of parotitis, and that such a meningitis can be transmitted to other cats by injecting the cerebrospinal fluid in the same manner. The cerebrospinal fluid does not, at any time, contain bacteria which grow with the ordinary culture methods.
Interstitial laser hyperthermia: a new approach to local destruction of tumours.
Authors: A. C. Steger, W. R. Lees, K. Walmsley, S. G. Bown
Journal: BMJ (1989)

The use of local hyperthermia to treat cancer of the internal organs has been limited by the difficulty of controlling delivery of heat and limiting the effects to the tumour, but this can be overcome by using laser light transmitted through thin flexible fibres. Laser energy was delivered to tumours through fibres inserted percutaneously through needles directly into the centre of the tumour area. Ultrasound scanning was used to locate the tumour, position the fibres correctly within the tumour, and monitor the development of thermal necrosis in real time during laser exposure and through the subsequent period of healing. Five patients were treated (one with a tumour of the breast, one with a subcutaneous secondary tumour, one with a recurrent pancreatic tumour, and two with secondary tumours in the liver). Tumour necrosis was found on ultrasonography or computed tomography in all, and there were no immediate or delayed complications. In one patient the size of the isolated secondary tumour in the liver had not increased over 10 months, and he subsequently showed no other evidence of residual cancer. To develop this technique careful studies are essential to ensure that in every case the extent of thermal necrosis produced by absorption of the laser light can be matched to the full extent of the tumour being treated and that there is always sufficient adjacent normal tissue to ensure safe healing. These preliminary results suggest that this simple technique can be applied safely and effectively to common tumours in humans; more extensive trials in a range of cancers of solid organs are warranted.
Liability for Transfusion-Acquired Disease
Authors: Herbert F. Polesky
Journal: JAMA (1987)

To  Editor.—  In a recent COMMENTARY, entitled Individual and Institutional Liability for Transfusion-Acquired Diseases, 1  authors correctly include Minnesota as one of five states without a statute classifying provision of blood as a service. However,  authors err in stating that the issue of blood bank liability has simply not arisen in  published opinions of... Minnesota. In a 1965 decision, Balkowitsch v Minneapolis War Memorial Blood Bank , 2  Supreme Court of Minnesota considered and resolved this issue. In holding that  relationship between  blood bank and  recipient was sui generis ,  Minnesota court aligned itself with  vast majority of jurisdictions that have declined to impose strict liability for transfusion.  The Balkowitsch plaintiff, who developed hepatitis following transfusion, claimed a breach of implied warranty under a contractual sales-act theory as well as strict liability in tort. The court rejected both of these theories. In
DNA Inhibition as an Explanation of Hydroxyurea Induced Megaloblastosis.
Authors: John W. Yarbro
Journal: Annals of Internal Medicine (1965)

s1 November 1965DNA Inhibition as an Explanation of Hydroxyurea Induced Megaloblastosis.John W. Yarbro, M.D. (Associate), Paul Engstrom, M.D., B. J. Kennedy, M.D., F.A.C.P.John W. Yarbro, M.D. (Associate)Search for more papers by this author, Paul Engstrom, M.D.Search for more papers by this author, B. J. Kennedy, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-917_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHydroxyurea is effective against a variety of neoplasms. During the administration of this agent, bone marrow suppression occurred as manifested by a decrease in reticulocytes, leukopenia, thrombocytopenia, and anemia. Most significantly, a marked megaloblastosis was observed during and immediately after the administration of hydroxyurea. Because of the relationship between megaloblastosis and nucleic acid metabolism, an investigation of this phenomena was undertaken by a study of the effect of hydroxyurea on nucleic acid metabolism in a transplantable ascites tumor in C3M mice. Nucleic acid synthesis was determined by means of incorporation of P32orthophosphate into deoxyribonucleic acid (DNA) and ribonucleic acid... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: John W. Yarbro, M.D. (Associate); Paul Engstrom, M.D.; B. J. Kennedy, M.D., F.A.C.P.Affiliations: Minneapolis, Minnesota PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1965Volume 63, Issue 5Page: 917-917KeywordsAnemiaAscitesBone marrowDNANucleic acidsPhosphatesRNAReticulocytes ePublished: 1 December 2008 Issue Published: 1 November 1965 PDF downloadLoading ...