Metoclopramide and Chemotherapy-Induced Emesis
Authors: B. ROBERT MEYER
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 July 1984Metoclopramide and Chemotherapy-Induced EmesisB. ROBERT MEYER, M.D., MARGARET LEWIN, M.D., MARK PASMANTIER, M.D., DENNIS E. DRAYER, M.D., MARCUS M. REIDENBERG, M.D.B. ROBERT MEYER, M.D.Search for more papers by this author, MARGARET LEWIN, M.D.Search for more papers by this author, MARK PASMANTIER, M.D.Search for more papers by this author, DENNIS E. DRAYER, M.D.Search for more papers by this author, MARCUS M. REIDENBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-1-141 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Benzodiazepines have been reported to be useful in the control of chemotherapy-induced emesis (1-3). Metoclopramide at doses of 2 mg/kg body weight every 2 hours is the single best agent for the control of cisplatin-induced emesis (4). We did a clinical trial to assess the usefulness of adding diazepam to a standard metoclopramide regimen for the control of cisplatin-induced emesis.Eligible patients were receiving cisplatin at doses of 60 to 100 mg/m2body surface area as part of a combination chemotherapy regimen and had no contraindication to either metoclopramide or diazepam. Metoclopramide dosage was 2 mg/kg every...References1. ROBINSERSHLERDEJONGH HWL. Anti-emetic effect of intravenous diazepam in patients receiving cis-diaminedi-chloroplatinum-II: a pilot study. Med Pediatr Oncol. 1979;7:247-9. CrossrefMedlineGoogle Scholar2. FRIEDLANDERKEARSLEYTATTERSALL MJM. Oral lorazepam to improve tolerance to cytotoxic chemotherapy. Lancet. 1981;1:1316-7. CrossrefMedlineGoogle Scholar3. MAHER J. Intravenous lorazepam to prevent nausea and vomiting associated with cancer chemotherapy. Lancet. 1981;1:91. CrossrefMedlineGoogle Scholar4. GRALLAITRIPISKO RLS. Anti-emetic efficacy of high dose metoclopramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomiting. N Engl J Med. 1981;305:905-9. CrossrefMedlineGoogle Scholar5. MEYERLEWINDRAYERPASMANTIERLONSKIREIDENBERG BMDMLM. Optimizing metoclopramide control of cisplatin-induced emesis. Ann Intern Med. 1984;100:393-5. LinkGoogle Scholar1. MEYERLEWINDRAYERPASMANTIERLONSKIREIDENBERG BMDMLM. Optimizing metoclopramide control of cisplatin-induced emesis. Ann Intern Med. 1984;100:393-5. LinkGoogle Scholar2. TAYLORBATEMAN WD. High-dose metoclopramide-preliminary pharmacokinetic studies. Br J Clin Pharmacol. 1983;16:341-2. CrossrefMedlineGoogle Scholar3. BATEMANPROCTORRAWLINSTAYLOR DSMW. Kinetics and efficacy of high-dose metoclopramide used in the prevention of cytotoxicinduced nausea and vomiting. Br J Pharmacol. 1983;80:490. Google Scholar4. BATEMANGOKALDODDBLAIN DRTP. The pharmacokinetics of single doses of metoclopramide in renal failure. Eur J Clin Pharmacol. 1981;19:437-41. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cornell University Medical College New York, NY 10021 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byReview: The Management of Nausea and Vomiting in Clinical OncologyGastrointestinal drugs 1 July 1984Volume 101, Issue 1Page: 141-142KeywordsBody surface areaBody weightClinical trialsCombination chemotherapyDiazepam Issue Published: 1 July 1984 PDF downloadLoading ...