The Pathogenesis of Gastroesophageal Reflux Disease: A Challenge in Clinical Physiology
Authors: Sidney Cohen
Journal: Annals of Internal Medicine (1992)

Editorials15 December 1992The Pathogenesis of Gastroesophageal Reflux Disease: A Challenge in Clinical PhysiologySidney Cohen, MDSidney Cohen, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-117-12-1051 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGastroesophageal reflux disease is a clinical syndrome that manifests as heartburn and the sequelae of esophagitis, ulceration, stricture, or Barrett epithelium. Adenocarcinoma of the esophagus in association with metaplastic columnar or Barrett epithelium is one of the most rapidly increasing malignancies recognized in the United States. Gastroesophageal reflux disease with its associated sequelae can now be readily diagnosed and effectively managed with histamine-2 antagonists, prokinetic agents, omeprazole, or antireflux surgery.Despite improved diagnosis and management of gastroesophageal reflux, the pathogenesis of this condition has remained controversial. The article by Sloan and colleagues (1), in this issue ofAnnals, uses modern...References1. SloanRademakerKahrilas SAP. Determinants of gastroesophageal junction incompetance: hiatal hernia, lower esophageal sphincter, or both? Ann Intern Med. 1992;117:977-82. LinkGoogle Scholar2. Harrington S. Various types of diaphragmatic hernia treated surgically: report of 430 cases. Surg Gynecol Obstet. 1948;86:735-50. MedlineGoogle Scholar3. FieldStalker PM. Incompetence of the cardiac sphincter without radiologic demonstration of hiatus hernia. Can J Surg. 1968;11:412-5. MedlineGoogle Scholar4. HiebertBelsey CR. Incompetency of the gastric cardia without radiologic evidence of a hiatal hernia. J Thorac Cardiovasc Surg. 1961;42:352-62. CrossrefMedlineGoogle Scholar5. BiancaniZabinskiBehar PMS. Pressure tension and force of closure of the human lower esophageal sphincter and esophagus. J Clin Invest. 1975;56:476-83. CrossrefMedlineGoogle Scholar6. Brick I. Incidence of hiatus hernia and associated lesions diagnosed by roentgen ray. Arch Surg. 1949;58:419-36. CrossrefMedlineGoogle Scholar7. DoddsDentHoganHelmHauserPatel WJWJRG. Mechanisms of gastroesophageal reflux in patients with reflux esophagitis. N Engl J Med. 1982;307:1547-52. CrossrefMedlineGoogle Scholar8. BoyleAltschulerNixonTuchmanPackCohen JSTDAS. Role of the diaphragm in the genesis of lower esophageal sphincter pressure in the cat. Gastroenterology. 1985;88:723-30. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Sidney Cohen, MDAffiliations: Temple University School of Medicine Philadelphia, PA 19140 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrug LawBarrett's Esophagus: Prevalence and Size of Hiatal HerniaTHE DIAGNOSIS AND MANAGEMENT OF GASTROESOPHAGEAL REFLUX DISEASEThe Pathophysiology of Gastro-oesophageal Reflux Disease: An Overview 15 December 1992Volume 117, Issue 12Page: 1051-1052KeywordsAdenocarcinomaEpitheliumEsophagusGastroesophageal reflux diseasePathogenesisSurgeryUlcers ePublished: 1 December 2008 Issue Published: 15 December 1992 PDF downloadLoading ...