tbuckley/cabot-search huggingface dataset:
Abstract 3165: microRNA-148a: A novel oncogenic microRNA in glioblastoma
Authors: Jungeun Kim, Ying Zhang, Fadila Guessous, Roger Abounader
Journal: Cancer Research (2012)

Abstract Glioblastoma is the most common and deadly malignant brain tumor. One main reason of resistance of glioblastoma to therapy is the ability of the tumor cells to migrate and invade the surrounding brain, rendering total surgical removal of the tumor practically impossible. MicroRNAs (miRNA) are small noncoding regulatory RNA molecules with emerging critical roles in cancer. MicroRNAs modulate protein expression by binding to the 3-untranslated region of mRNA and promoting RNA degradation or inhibiting transcription. In this study, we analyzed data from The Cancer Genome Atlas (TCGA) and found that microRNA-148a (miR-148a) was one of few miRNAs that inversely correlated with GBM patient survival. However, nothing is known about the role of this miRNA in cancer and GBM. We therefore started a systematic study of miR-148a in GBM. We first measured miR-148a levels in GBM and found that they were &amp;gt; 3-fold higher in GBM stem cells than in normal astrocytes and ∼15 times higher in tumor specimens than in and normal brain. We then investigated the functional effects of miR-148a on GBM malignancy. Inhibition of miR-148a in GBM stem with anti-miR-148a strongly induced apoptosis. Overexpression of miR-148a in GBM stem cells strongly promoted their self-renewal ability. Transfection of pre-miR-148a into GBM cells strongly promoted cell proliferation, migration and invasion though a membrane coated with collagen IV, a commonly expressed matrix protein in GBM. Therefore, miR-148a acts as an oncogene in GBM cells by promoting cell proliferation, migration and invasion and inhibiting stem cell differentiation. To elucidate the mode of action and targets of miR-148a in GBM, we used a combined approach of miRNA target prediction analysis and immunoblotting to identify oncogenes that are targeted and inhibited by miR-148a. We selected proteins that are known to play roles in GBM and cancer, and were able to confirm inhibition by miR-148a of MIG6 and BIM. MIG6 is a negative regulator of EGFR (an important oncogene in GBM), and BIM is a central pro-apoptotic molecule. Therefore, we predicted that miR-148a might act as an oncogenic microRNA by inducing EGFR expression and activation and inhibiting apoptosis. Using immunoblotting, we demonstrated that miR-148a does in fact induce EGFR expression and activation in GBM cells. Ongoing and future studies will assess the in vivo effects of miR-148a and evaluate its usefulness as a new target for GBM therapy. Altogether, we have uncovered miR-148a a new oncogenic microRNA in GBM that acts via regulation of EGFR and BIM. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3165. doi:1538-7445.AM2012-3165
Hay-fever Ionization Clinic
Authors: P. Franklin
Journal: BMJ (1939)

NASAL INJURY MEDTIL JTOURNAT 871 18, 1935, when in perfect health, he was involved in a motor accident, sustaining cerebral concussion, fractured right fibula, lacerated wounds of the forehead and left orbital regions, and bruising of the facial tissues, hands, and left knee.He was admitted to Hove Hospital, where he was unconscious for twenty-four hours.Three attempts to control the fragments of the fibula were made.and finally a bone peg was inserted and he was discharged with the leg in plaster.On October 4, 1935, he developed acute nocturnal dyspnoea, expiratory in type, of great severity.On examination the lungs were full of expiratory sounds.There was a forked scar over the side of the bridge of the nose, the two limbs running up the forehead and over the right eyebrow.The nose internally showed obstruction of the left naris.Adrena- line relieved the attack, but though further treatment with a nasal spray of ephedrine and chloretone, and the usual drugs internally, kept the more violent paroxysms under control, the patient was in constant discomfort.With the former case in mind, he was referred to Mr. Harold Downer, who reported: "The nasal septum is markedly deflected to the
THE NEOPLASTIC POTENTIALITIES OF MOUSE EMBRYO TISSUES
Authors: Peyton Rous, William E. Smith
Journal: The Journal of Experimental Medicine (1945)

A method has been devised whereby the transplanted epidermis of mouse embryos can be selectively exposed to the action of a chemical carcinogen. Scharlach R was dissolved in olive oil with the aim of stimulating and attracting the epidermal cells, methylcholanthrene was added to the solution, and numerous fine globules of it were injected into the thigh muscles of adult mice together with fragments of embryo skin. Much of the oil underwent primary inclusion in the resulting cysts, and the proliferating epidermis, while forming them, extended to not a few of the outlying droplets with result that they too were added to the cyst contents. During these activities the methylcholanthrene came into direct contact with many of the epithelial cells, and later on the layer lining the cyst was continually exposed to the influence of the carcinogen. The epidermis underwent neoplastic changes with great rapidity; often in less than 4 weeks papillomas and carcinomas had arisen like those deriving from adult epidermis. The growths were punctate in origin and usually multiple. Many were transplanted to adults of the same homologous breed of mice that furnished the embryo material (mice of C strain). The grafts did not uniformly succeed as was the case with those of normal skin of embryos of the same stock,-which regularly grew at first in the new hosts and remained alive long after. The benign papillomas failed to live or barely survived, and the apparently malignant papillomas, though rapidly forming nodules of considerable size, usually regressed later. Some of the carcinomas also regressed or wholly failed, while others gave rise to progressively enlarging tumors. The best results were obtained with grafts in which several neoplasms were intermingled, these flourishing together in the new hosts. Methylcholanthrene in olive oil exerts an influence on epidermal cells like that of Scharlach R, stimulating them to multiply, attracting them, and causing them to mimic carcinomatous elements.
Effect of murine liver cell proliferation on herpes viral behavior: Implications for oncolytic viral therapy
Authors: Keith A. Delman, Jonathan S. Zager, Amit Bhargava, Henrik Petrowsky, Sandeep Malhotra, Michael I. Ebright, Joseph J. Bennett, Niraj J. Gusani, David A. Kooby, Gretchen D. Roberts, Yuman Fong
Journal: Hepatology (2004)

Replication-competent herpes simplex oncolytic viruses are promising anticancer agents that partly target increased DNA synthesis in tumor cells. Investigators have proposed that these DNA viruses may be combined with liver resection to enhance killing of liver malignancies. Whether or not the cellular alterations associated with hepatic regeneration affect the efficacy and toxicity of these promising anticancer agents is unknown. This study examined the behavior of two oncolytic viruses, NV1020 and G207, during liver regeneration. When delivered during the peak of liver regeneration, replication and appearance of both G207 and NV1020 in hepatic tissue are enhanced as demonstrated by histochemical staining for the marker gene lac Z, immunohistochemical staining, and quantitative polymerase chain reaction. This increased appearance of virus in liver tissue correlates with increases in cellular ribonucleotide reductase activity and DNA synthesis and is also associated with increased viral binding. However, increased viral presence is transient, and viral detection declines to baseline within 7 days. When these viruses were delivered to animals even as early as 7 days after hepatectomy, there proved to be no measurable viral replication in any organ and no increased morbidity or mortality. In conclusion, the early stages of hepatic regeneration after resection provide an environment suitable for viral replication. Administration of replication-competent herpes simplex virus during the peak of hepatocyte regeneration (24-48 hours) permits viral productivity in tissue that otherwise does not support viral growth. The increase in hepatotoxicity after hepatectomy is short-lived and can be predicted by peak hepatocyte DNA synthesis.
Endoscopic hook knife cutting before balloon dilatation of a severe anastomotic stricture after rectal cancer resection
Authors: M. Mukai, K. Kishima, S. Iizuka, H. Fukumitsu, M. Fukasawa, N. Yazawa, T. Tajima, M. Nakamura, H. Makuuchi
Journal: Endoscopy (2009)

Anastomotic stricture associated with suture failure develops in 5 % – 10 % of patients after resection of rectal cancer [1]. Direct digital dilatation or transrectal surgical treatment is possible if the anastomosis is located in the lower rectum. Endoscopic balloon dilatation is the best method for all the remaining patients in whom these procedures for the lower rectum cannot be done [2]. However, double stapling of the rectal anastomosis may induce intractable and severe re-stenosis, so a procedure that includes endoscopic incision with a papillotomy knife has been reported [3] [4].
Assessment of liver fibrosis with transient elastography and FibroTest in patients treated with methotrexate for chronic inflammatory diseases: A case–control study
Authors: David Laharie, Julien Seneschal, Thierry Schaeverbeke, Marie-Sylvie Doutre, Maïté Longy-Boursier, Jean-Luc Pellegrin, Edouard Chabrun, Sandrine Villars, Frank Zerbib, Victor de Lédinghen
Journal: Journal of Hepatology (2010)
Hypercalcemia and Neuromuscular Disease
Authors: JOHN SOUCIE
Journal: Annals of Internal Medicine (1974)

Comments1 July 1974Hypercalcemia and Neuromuscular DiseaseJOHN SOUCIE, M.D.JOHN SOUCIE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-1-128_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I read with much interest your article on neuromuscular disease in primary hyperparathyroidism (Ann Intern Med 80:182-193, 1974). I wish to report a case of primary hyperparathyroidism observed by me as senior resident at the Henry Ford Hospital in Detroit. The patient had a parathyroid carcinoma with extreme symptoms of neuromuscular disease not cured by excision of her lesion.The patient, a 38-year-old woman, was transferred from a local nearby hospital to the nephrology service because of azotemia and a serum calcium of 14.8/100 ml. The patient suffered from hypercalcemia and subsequently developed severe septic shock that...References1. PATTENBILEZIKIANMALLETTE BJL: Neuromuscular disease in primary hyperparathyroidism. Ann Intern Med 80:182-193, 1974 LinkGoogle Scholar2. RYANCHERINGTON DM: Human type A botulism. JAMA 216:513-514, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine and Respiratory Disease Royal Victoria Hospital Montreal, Quebec, Canada H3C 3GI PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Neuromuscular Manifestations of Primary Hyperparathyroidism in Humans 1 July 1974Volume 81, Issue 1Page: 128-129KeywordsCalciumHypercalcemiaHyperparathyroidismLesionsNephrologyNeuromuscular diseasesParathyroid tumorsShock Issue Published: 1 July 1974 PDF DownloadLoading ...
Effect of the inflammation, chronic hyperglycemia, or malabsorption on the apolipoprotein A-IV concentration in type 1 diabetes mellitus and in diabetes secondary to chronic pancreatitis
Authors: Didier Quilliot, Evelyne Walters, Bruno Guerci, Jean-Charles Fruchart, Patrick Duriez, Pierre Drouin, Olivier Ziegler
Journal: Metabolism (2001)
(25) Disseminated minute keratoses
Authors: M. Goodfield, N.R. Rowell
Journal: British Journal of Dermatology (1987)

Journal Article (25) Disseminated minute keratoses Get access M. Goodfield, M. Goodfield The General Infirmary at Leeds Search for other works by this author on: Oxford Academic Google Scholar N.R. Rowell N.R. Rowell The General Infirmary at Leeds Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue s32, 1 June 1987, Pages 72–73, https://doi.org/10.1111/j.1365-2133.1987.tb12065.x Published: 01 June 1987
Examination of Liquor Amnii as a Method of Predicting Severity of Haemolytic Disease of Newborn
Authors: W. Walker, D. V. I. Fairweather, P. Jones
Journal: BMJ (1964)

Very severe= Cord haemoglobin less than 9 g./100 ml., or cord bilirubin over 7 mg./100ml., or overt very severe clinical disease at birth where cord blood values were not known.Moderate=All other infants less severely affected but needing treatment.Mild=Coombs-positive infants who did not require treatment.Rh-negative =Unaffected infants.In a few patients with a bad obstetric history amniocentesis was carried out at 32-33 weeks' gestation and in many others
Telemonitoring for patients with COPD
Authors: R. Jordan, P. Adab, K. Jolly
Journal: BMJ (2013)

Adds little to well supported self management 

Telemonitoring has been promoted as a potential solution to the management of rising numbers of patients worldwide with long term health problems. Although there is some evidence that such interventions empower patients to change behaviour, their effect on clinical outcomes is not clear.1 In a linked paper (doi:10.1136/bmj.f6070), Pinnock and colleagues report the results of their telemonitoring trial in 256 patients with chronic obstructive pulmonary disease (COPD) admitted to hospital in the previous year with an exacerbation.2 

COPD is one of the most common long term conditions and is expensive because exacerbations often lead to hospital admission. Patients are encouraged to self manage their disease by recognising exacerbations and self medicating to limit the impact of an exacerbation (action planning), thus avoiding admission. Cochrane systematic reviews conclude that education on self management is associated with a reduced risk of hospital admission,3 although action plans with limited education have no effect.4 

Another approach to timely management of exacerbations is the telemonitoring of patients’ symptoms by a remote clinical team, although evidence for the effectiveness of this approach is conflicting. Systematic reviews highlight the heterogeneity of interventions and the difficulty in isolating the …
Digestion Assays in Allergenicity Assessment of Transgenic Proteins
Authors: Rod A. Herman, Nicholas P. Storer, Yong Gao
Journal: Environmental Health Perspectives (2006)

The food-allergy risk assessment for transgenic proteins expressed in crops is currently based on a weight-of-evidence approach that holistically considers multiple lines of evidence. This approach recognizes that no single test or property is known to distinguish allergens from nonallergens. The stability of a protein to digestion, as predicted by an in vitro simulated gastric fluid assay, currently is used as one element in the risk assessment process. A review of the literature on the use of the simulated gastric fluid assay to predict the allergenic status of proteins suggests that more extensive kinetic studies with well-characterized reference proteins are required before the predictive value of this assay can be adequately judged.
Acute leukemia with mediastinal mass, lymphadenopathy, and monocytic precursor cells
Authors: Josef D. Schwarzmeier, Peter Bettelheim, Thaddäus Radaszkiewicz, Friedrich Prischl, Michael Schwabe, Manfred Fuhrmann
Journal: American Journal of Hematology (1986)

Abstract Cell marker analysis with monoclonal antibodies (MoAb) as well as differentiation studies with the chemical inducer TPA were used to identify a population of apparently lymphoid cells as monocytic precursor cells in a patient with acute leukemia. The initial manifestation of the disease with mediastinal mass and lymphadenopathy was followed by the appearance of small lymphocyte‐like blast cells in bone marrow (BM) and peripheral blood (PB). Although a lymph node biopsy revealed an infiltration with monoblasts, the leukemic cells in BM and PB were not classifiable. However, when the patient relapsed after chemotherapy with large monoblasts and again with morphologically lymphoid blast cells, the latter could be classified by treatment with TPA. After incubation with the inducer (12–48 hr) the cells became positive with the MoAB VIM‐D5, showed a strong reaction with α‐napthyl‐acetate‐esterase and developed macrophage like morphology, as well as phagocytic properties. During the terminal phase of the disease, small, lymphocyte‐like blast cells predominated. These cells could be classified by a panel of MoABs. They expressed myeloid determinants (VIM‐D5, VIM‐2, MY 9, VIM‐12, VIM‐13) but showed no reactivity with MoABs specific for lymphocytic cells.
Origin of body surface QRS and T wave potentials from epicardial potential distributions in the intact chimpanzee.
Authors: M S Spach, R C Barr, C F Lanning, P C Tucek
Journal: Circulation (1977)

Epicardial and body surface QRS-T wave potential distributions were measured during normal and ectopic sequences in intact chimpanzees. Epicardial potential distributions were used because they provide a comprehensive picture of total cardiac electrical activity for relating heart and body surface events during both ventricular activation and repolarization. When the epicardial potential gradients existed over a distance greater than that to the recording points on the body surface, e.g., as occurred during the overlap of terminal ventricular activation and early repolarization, the epicardial events were mirrored well on the anterior chest surface. However, when the recording points were at a distance greater than that over which the epicardial potential gradients existed, the details of the epicardial events disappeared and their effect was to produce distinct changes in the low-level potentials over broad distant areas. The major manifestations on the body surface of selective epicardial events frequently were changes in the distant low-level potential areas while there was no change in the pattern near the maximum or minimum. The ST-T wave body surface distributions were as useful as the QRS patterns for localizing the ventricular ectopic foci presented. A direct experimental basis is provided for explaining T wave notches which occurred during normal and ectopic beats and resembled U waves. It should be possible to achieve as precise an understanding of ST-T waves on the basis of epicardial potential distributions as has thus far been achieved for QRS on the basis of isochrones.
Argyll Robertson and Münchhausen or Münchausen Or Munchausen
Authors: Don H. Nicholson
Journal: JAMA (1969)

<h3>To the Editor:—</h3> Your well-intended editorial "Eponyms" (<b>207</b>:1142, 1969) helped perpetuate the improper hyphenation of Douglas Argyll Robertson's name. This error is so widespread that public correction of your mistake will probably, not have an appreciable effect in diminishing its future frequency. However, since 1969 marks the centennial of the two publications<sup>1,2</sup>initially describing his pupillary sign, some extra effort seems warranted to keep the form of this eponym correct. A recent biographical sketch<sup>3</sup>and a re-publication of his second paper on "spinal myosis"<sup>4</sup>are readily available sources of information about this remarkable Scotsman, who is said to have had no peer with either von Graefe knife or mashie niblick. A second error, which would be too minor to bother about, I suppose, had it not appeared in an article on the subject of eponyms, is the umlaut over the "a" in Munchausen's syndrome. The excellent
Management of massive upper gastrointestinal haemorrhage from multiple sites of peptic ulceration with somatostatin and octreotide--a report of five cases.
Authors: S A Jenkins, B A Taylor, D M Nott, S Ellenbogen, J Haggie, R Shields
Journal: Gut (1992)

Surgical management of massive upper gastrointestinal bleeding after failed medical treatment may be hazardous because of diffuse bleeding from several sites, further complicated in some patients by intercurrent disease, age, or previous surgery. Experience with combined somatostatin and octreotide therapy in five such patients is described. All were treated initially with either intravenous somatostatin (250 micrograms/hour) or octreotide (Sandostatin) (50 micrograms/hour) for periods ranging from three to five days, after which they were given subcutaneous octreotide (50 or 100 micrograms three times daily). Bleeding was controlled by this regimen in all cases. The patients were all discharged from hospital on either ranitidine (n = 4) or omeprazole (n = 1). Repeat endoscopy at the end of the treatment period with somatostatin and octreotide (n = 1) or four weeks after discharge (n = 3) showed complete healing of the bleeding sites. Somatostatin and octreotide may be of value in controlling severe upper gastrointestinal bleeding in patients in whom surgery is hazardous because of bleeding from several peptic lesions further complicated in some by intercurrent disease or age.
Protein and allergen content of various natural latex articles
Authors: X. Baur, Z. Chen, M. Raulf‐Heimsoth, P. Degens
Journal: Allergy (1997)

Proteins remaining in products made of natural rubber latex are potential sensitizers. In the present work, we quantified the releasable protein and allergen contents in 37 brands of latex gloves and 26 other latex products. Our results demonstrate the presence of widely varied protein and allergen contents in various latex articles and the lack of a correlation between the protein and allergen values. These findings may assist hospital management and medical staff to take effective preventive measures.
Dietary sodium intake, airway responsiveness, and cellular sodium transport.
Authors: R M Tribe, J R Barton, L Poston, P G Burney
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

Both epidemiologic and experimental evidence suggest that a high dietary sodium intake may increase airway responsiveness, but no adequate explanation exists of how changes in sodium intake might lead to increased responsiveness. This investigation was carried out to study dietary sodium intake and airway response to methacholine in relation to cellular sodium transport in 52 young men. Airway response to methacholine was associated with urinary sodium excretion when subjects were on normal sodium intake. Airway responsiveness in patients with mild asthma correlated with the furosemide-insensitive influx of sodium into peripheral leukocytes stimulated by autologous serum, but there was no relation between this influx and 24-h urinary sodium excretion. In a separate investigation, serum from subjects with increased airway responsiveness caused an increase in the sodium influx and sodium content of leukocytes from nonatopic subjects. The magnitude of the furosemide-insensitive, serum stimulated influx was related to the degree of airway responsiveness of the serum donor, as was the increase in intracellular sodium content. Neither was related to the 24-h urinary sodium excretion of the donor. Patients with airway hyperresponsiveness have an increased sodium influx into cells stimulated by a serum-borne factor. This is independent of the effect of added dietary sodium on airway responsiveness.