tbuckley/cabot-search huggingface dataset:
Long-term changes in mitral valve area after successful mitral commissurotomy.
Authors: J J Heger, L S Wann, A E Weyman, J C Dillon, H Feigenbaum
Journal: Circulation (1979)

We examined the long-term effects of closed instrumental mitral commissurotomy on mitral valve area (MVA) in 18 patients, followed for as long as 14 years after successful operation. Each patient had preoperative and early postoperative cardiac catheterization; late postoperative determination of MVA was obtained 10-14 years (mean 12.2 years) after commissurotomy. In 17 patients, the MVA was determined by cross-sectional echocardiography and in one patient by repeat cardiac catheterization. Thirteen of 18 patients had no change in MVA between early postoperative study (mean MVA = 2.7 cm2) and late postoperative study (mean MVA = 2.9 CM2). MVA in five patients decreased 0.7-2.2 cm2 (mean 1.4 cm2) during the follow-up period. In these five patients, the mean MVA at early postoperative study was 2.7 cm2 and at late postoperative study was 1.3 cm2 (p less than 0.001). At late postoperative evaluation, cardiac symptoms were associated with severity of mitral stenosis but did not predict restenosis. A successful, closed, instrumental mitral commisurotomy can provide substantial long-term improvement in MVA.
Is Hodgkin's Disease Contagious?
Authors: Brian MacMahon
Journal: New England Journal of Medicine (1973)

In this issue of the Journal, Vianna and Polan present further evidence to support their view that Hodgkin's disease may be contagious. The hypothesis, as previously stated by the Albany group 1 , 2 and supported in this paper, is that Hodgkin's disease occurs more frequently than one would expect among the close contacts of persons with the disease and among persons linked to patients through contact with unaffected intermediaries. Such words as "transmission," "carrier" and "incubation period" appear frequently in the writings of the group and make explicit the analogy to a contagious infectious disease.Pyrexia, eosinophilia and granulomatous histology have led . . .
Abstract 4487: Synergistic effects of resveratrol and doxorubicin on inducing the apotosis of mouse and human PTEN deficient T-cell acute lymphoblastic cells.
Authors: Ling Chen, Yaling Yang, M. James You
Journal: Cancer Research (2013)

Abstract Resveratrol (3,5,4’-trihydroxy-trans-stilbene), a plant antibiotic produced in a wide variety of plants in response to stress, injury, UV irradiation, and fungal infection, has been shown to inhibit cell growth of several types of cancer. The aim of the present study was to determine the effects of Resveratrol alone and its combination with Doxorubicin, a commonly used chemotherapeutics for T-cell acute lymphoblastic leukemia (T-ALL), on the proliferation and apoptosis of T-ALL cells. Mouse T-ALL cell lines were derived from T-cell-specific deletion of Pten tumor suppressor gene, and human T-ALL cells were obtained from ATCC. We treated T-ALL cells with different concentrations of Resveratrol (0 μM to 200 μM) alone and in combination with various concentrations of Doxorubicin (0 μM to 1 μM) for different durations (0, 12, 24, 48 and 72 hours, respectively). We showed mouse and human Pten deficient T-ALL cell lines were sensitive to the treatment of Resveratrol in dose- and time-dependent manners. In addition, low dose Resveratrol (3.125 μM) in combination with very low dose of o (0.01 μM) showed a remarkable synergistic effect on the cell proliferation and apoptosis. Flow cytometric analysis with Annexin V and Western blot studies on Caspase 3 confirmed that Resveratrol induced apoptosis, especially in combination with Doxorubicin. This study establishes a potential role of Resveratrol in the treatment of Pten deficient T-ALL. Citation Format: Ling Chen, Yaling Yang, M. James You. Synergistic effects of resveratrol and doxorubicin on inducing the apotosis of mouse and human PTEN deficient T-cell acute lymphoblastic cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4487. doi:10.1158/1538-7445.AM2013-4487
COMPLETE INVERSION OF THE UTERUS WITH SUBSEQUENT REDUCTION AND RECOVERY.
Authors: J. M. McCOMAS
Journal: JAMA (1904)

<h3>Patient.</h3> —Mrs. W. F. M., age 29 years, a farmer's wife, who had been delivered of a female child Feb. 10, 1902, was admitted to the Southwestern Hospital, Elk City, Okla., March 12, 1902. <h3>History.</h3> —Patient's own statement: "I have always been stout and well, have given birth to three children, one aged 4, one aged two years, and the one just recently born. When my labor came on I sent for a midwife, Mrs. Hughes, my neighbor who lives near by, and when my child was born I was so nearly dead we sent for a physician, who came and said I had a large tumor, gave me some medicine and left the house." The social and family history of this patient gives no information other than that she was without constitutional taint and had always followed a plain and simple mode of living. <h3>Examination.</h3> —An
Effects of ethanol feeding and withdrawal on plasma glutathione elimination in the rat
Authors: David J. Callans, Laura S. Wacker, Mack C. Mitchell
Journal: Hepatology (1987)

Chronic ethanol feeding increases hepatic turnover and sinusoidal efflux of glutathione in rats. The present study was performed to determine whether the observed increase in glutathione efflux was due to increased extrahepatic requirements for glutathione. The concentration and disposition of plasma glutathione were determined in rats fed liquid diets containing 36% of calories as ethanol or pair-fed an isocaloric mixture with carbohydrate replacing ethanol calories for 5 to 8 weeks. The half-life and plasma clearance of [35S]glutathione were found to be similar in ethanol-fed and control rats and in rats withdrawn 24 hr from ethanol. Uptakes of the sulfur moiety of [35S]glutathione by kidney, jejunal mucosa, liver, lung, spleen, muscle and heart were also unchanged by ethanol feeding. The plasma glutathione concentration was significantly higher in ethanol-withdrawn rats 22.30 ± 3.06 nmoles per ml (p < 0.05) compared to pair-fed controls (13.51 ± 2.04), while rats continuing to drink ethanol had intermediate levels (16.96 ± 2.22). Plasma cysteine levels were slightly, but not significantly, higher in ethanol-fed rats. These findings suggest that increased sinusoidal efflux of glutathione in ethanol-fed rats is due to a direct effect of ethanol on hepatic glutathione transport and not due to an alteration in extrahepatic disposition of glutathione. In order to characterize further the effects of ethanol feeding on glutathione-dependent detoxification, activities of glutathione S-transferase, glutathione reductase and γ-glu-tamyltransferase were determined. Both glutathione S-transferase and glutathione reductase activities were significantly increased by ethanol feeding whereas γ-glutamyltransferase was increased only slightly. Thus, chronic ethanol feeding in rats results in altered hepatic glutathione metabolism, both through nondetoxification pathways and potentially by glutathione-dependent detoxification enzymes.
The Facial Nerve
Authors: Charles M. Poser
Journal: JAMA (1980)

This unusual volume fills an important gap in the neuro-otological literature. It brings together a tremendous amount of information, which must normally be sought in a variety of textbooks and journals. In fact, it incorporates rarely found material on a number of exotic conditions. The authors have a clearly surgical otolaryngological orientation. As a result, the sections dealing with trauma to the facial nerve and the surgical approach to various lesions involving it are particularly informative. The book is remarkably up-to-date in most respects, incorporating the newest neurophysiological and radiological diagnostic techniques. The bibliography is also up-to-date and extensive. At times, however, the surgical orientation leads to overenthusiasm in that direction; tarsorrhaphy to protect the eye in a patient with Bell's palsy should certainly not be the procedure of choice as the authors suggest. Some of the statements are close to being incorrect, eg, the involvement of the facial musculature
ERCP cannulation of a hidden papilla within a duodenal diverticulum
Authors: J. García-Cano
Journal: Endoscopy (2008)

In expert hands, bile duct access using endoscopic retrograde cholangiopancreatography (ERCP) is almost always successful [1]. Nevertheless, to achieve deep common bile duct (CBD) cannulation, a great variety of techniques and devices must sometimes be employed by the biliary endoscopist [2]. A hidden papilla within a duodenal diverticulum is sometimes challenging. A case is presented here in which two special techniques of bile duct cannulation were used ([Video 1]).
Book Review Assessing Genetic Risks: Implications for health and social policy Edited by Lori B. Andrews, Jane E. Fullarton, Neil A. Holtzman, and Arno G. Motulsky. 338 pp. Washington, D.C., National Academy Press, 1994. $44.95. 0-309-04798-6
Authors: Theodore Krontiris
Journal: New England Journal of Medicine (1995)
Abstract 5325: Localized tumor growth in bone: Quantification of tumor burden, bone destruction, and weight-bearing capability in MDA-MB-231 human mammary carcinoma xenograft-bearing immunodeficient rats
Authors: Kellie A. Brune, Elizabeth A. Misener, Harlan Shannon, Jeffrey A. Wolos
Journal: Cancer Research (2011)

Abstract Metastatic bone disease is common in multiple myeloma, breast, prostate, and lung cancer patients and is a frequent cause of morbidity in advanced disease. Metastatic bone tumors destroy bone and cause severe bone remodeling which leads to structural weakening and bone fractures and often results in severe bone pain in a large percentage of patients. These studies examined tumor growth, bone erosion, and pain in a nude rat model. A surgical defect was created in the tibia, exposing the marrow cavity. Luciferase-expressing MDA-MB-231 mammary tumor cells were injected into the exposed bone cavity. Rats inoculated with tumor cells were treated with either doxorubicin (3 mg/kg/week, iv) or risedronate (80 ug/kg/day, ip). Animals were monitored weekly for tumor burden by optical imaging and for bone erosion by CT. In addition to clinical observations, weight bearing was measured using an incapacitance tester with separate force transducers for each hind paw. Compared to controls, rats treated with doxorubicin demonstrated a significant decease in luminescence, indicating tumor growth inhibition (bone protection). Decreased luminescence correlated with sparing of the bone as measured by CT. In contrast, the bisphosphonate, risedronate, had limited effect on tumor growth, but preserved bone integrity. In both treatments, protection of bone was associated with normalization of weight-bearing. This finding supports the premise that pain in metastatic bone cancer is attributable to bone loss (destruction) and remodeling. Weight-bearing data correlated directly with clinical observations This model, leveraging multiple imaging modalities, enables longitudinal and quantitative assessment of tumor growth; bone loss, remodeling and sparing, and weight-bearing in test animals that provides a sensitive and robust screening tool to evaluate compounds for anti-tumor, bone-sparing and pain amelioration effects. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5325. doi:10.1158/1538-7445.AM2011-5325
EFFECTS OF CHLORDIAZEPOXIDE IN SEVERELY DISTURBED OUTPATIENTS
Authors: FELIX BAMBACE
Journal: American Journal of Psychiatry (1961)

Of 73 outpatients with predominantly psychotic diagnoses the results of Librium therapy were excellent in 39 and good in 11. The drug relieved symptoms of anxiety, phobias, obsessive thinking and compulsive behavior, exogenous depressions, and conversion reactions. Librium was less effective in manic-depression, psychotic depressions and paranoid-type schizophrenia. Slight and transient side effects, mainly drowsiness and ataxia, occurred in a few cases. Patients with a long history of illness and hospitalization, who had not responded to previous medication with one or several of the phenothiazines, showed marked improvement under Librium therapy.
Evaluating the Risks of Electric Uterine Morcellation
Authors: Kimberly A. Kho, Ceana H. Nezhat
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AN OUTBREAK OF PARATYPHOID B FEVER PRESENTING NOVEL FEATURES
Authors: A. Graham-Stewart, P. Manson-Bahr, T. R. Goddard
Journal: BMJ (1928)

OTUTBREAK OF PABATYPHOID B FEVER. f Thz BmB W. M.? aged 29, had severe influenza in 1901, appendicitis in 1903, and appendicectomy in 1907, followed by prolonged insomnia anid mental depression.He returned to work, but in 1911, after % mild attack of influenza, headaches, and depression with suicidal impulses, culminating in delusional insanity, he was again unable to work.He was found to have staphylococcal infection involving all his nasal sinuses.The sinuses were radically operated on to eliminate all the focal sepsis, and after some moniths lhe FiG.8.-Sphenoidal sinus (M.L.), showing perforation of pituitaryfssa from splienoidal sinus.Note especially the bony r-idge withini the fossa indicative of long-standing infection.lost his delusions, regained his mental balance, and returned to work.He remained in uninterrupted health, and has occupied the position of bank manager for sixteen years.
Association Between Cholecystectomy With vs Without Intraoperative Cholangiography and Risk of Common Duct Injury
Authors: Kristin M. Sheffield, Taylor S. Riall, Yimei Han, Yong-Fang Kuo, Courtney M. Townsend, James S. Goodwin
Journal: JAMA (2013)

<h3>Importance</h3> Significant controversy exists regarding routine intraoperative cholangiography in preventing common duct injury during cholecystectomy. <h3>Objective</h3> To investigate the association between intraoperative cholangiography use during cholecystectomy and common duct injury. <h3>Design, Setting, and Participants</h3> Retrospective cohort study of all Texas Medicare claims data from 2000 through 2009. We identified Medicare beneficiaries 66 years or older who underwent inpatient or outpatient cholecystectomy for biliary colic or biliary dyskinesia, acute cholecystitis, or chronic cholecystitis. We compared results from multilevel logistic regression models to the instrumental variable analyses. <h3>Interventions</h3> Intraoperative cholangiography use during cholecystectomy was determined at the level of the patients (yes/no), hospitals (percentage intraoperative cholangiography use for all cholecystectomies at the hospital), and surgeons (percentage use for all cholecystectomies performed by the surgeon). Percentage of use at the hospital and percentage of use by surgeon were the instrumental variables. <h3>Main Outcomes and Measures</h3> Patients with claims for common duct repair operations within 1 year of cholecystectomy were considered as having major common duct injury. <h3>Results</h3> Of 92 932 patients undergoing cholecystectomy, 37 533 (40.4%) underwent concurrent intraoperative cholangiography and 280 (0.30%) had a common duct injury. The common duct injury rate was 0.21% among patients with intraoperative cholangiography and 0.36% among patients without it. In a logistic regression model controlling for patient, surgeon, and hospital characteristics, the odds of common duct injury for cholecystectomies performed without intraoperative cholangiography were increased compared with those performed with it (OR, 1.79 [95% CI, 1.35-2.36];<i>P</i> &lt; .001). When confounding was controlled with instrumental variable analysis, the association between cholecystectomy performed without intraoperative cholangiography and duct injury was no longer significant (OR, 1.26 [95% CI, 0.81-1.96];<i>P</i> = .31). <h3>Conclusions and Relevance</h3> When confounders were controlled with instrumental variable analysis, there was no statistically significant association between intraoperative cholangiography and common duct injury. Intraoperative cholangiography is not effective as a preventive strategy against common duct injury during cholecystectomy.
Learning from low income countries: what are the lessons?: Communities should decide priorities
Authors: Paul Eunson
Journal: BMJ (2004)

EDITOR—Women and children continue to die needlessly in developing countries. We know the causes but seem powerless to prevent their deaths. Constraints within health systems are blocking improvements, and we don't know enough about how to strengthen and sustain them without external investment. Individuals and communities have their own priorities for health, and a global solution for disease and poverty is impossible to prescribe.

A village was asked by an aid agency what its priorities for development aid would be, the answer presumed to be a health …
SUPERIORITY OF PULSE WAVE VELOCITY FOR CARDIOVASCULAR RISK ASSESSMENT AMONG NONINVASIVE ARTERIAL STIFFNESS PARAMETERS IN THE GENERAL POPULATION
Authors: Takenori Ishisone, Masahide Nagano, Masayuki Onodera, Yorihiko Koeda, Kenyu Sato, Fumitaka Tanaka, Motoyuki Nakamura
Journal: Journal of the American College of Cardiology (2013)
460 PROTEIN-INDEPENDENT CYTOSOL-NUCLEUS TRAFFIC OF BILE ACIDS, SUBNUCLEAR COLOCALIZATION WITH FXR AND ROLE OF ABC TRANSPORTERS IN THE HEPATOCYTE NUCLEUS ENVELOPE
Authors: R. Rosales, M.J. Monte, A.G. Blazquez, R.I.R. Macias, E. Herraez, M.J. Perez, F. Gonzalez-San Martin, J.J.G. Marin
Journal: Journal of Hepatology (2008)
Elucidation of a novel pathogenomic mechanism using genome-wide long mate-pair sequencing of a congenital t(16;21) in a series of three RUNX1-mutated FPD/AML pedigrees
Authors: A Buijs, M Poot, S van der Crabben, B van der Zwaag, E van Binsbergen, M J van Roosmalen, M Tavakoli-Yaraki, O de Weerdt, H K Nieuwenhuis, M van Gijn, W P Kloosterman
Journal: Leukemia (2012)
Comorbidity profiles among patients with alopecia areata: The importance of onset age, a nationwide population-based study
Authors: Szu-Ying Chu, Yi-Ju Chen, Wei-Cheng Tseng, Ming-Wei Lin, Tzeng-Ji Chen, Chian-Yaw Hwang, Chih-Chiang Chen, Ding-Dar Lee, Yun-Ting Chang, Wen-Jen Wang, Han-Nan Liu
Journal: Journal of the American Academy of Dermatology (2011)
Do Methodological Flaws Invalidate a Randomized Trial of Lifestyle Modification Programs in Obese Patients?
Authors: Vance W. Berger
Journal: Annals of Internal Medicine (2009)

Letters7 July 2009Do Methodological Flaws Invalidate a Randomized Trial of Lifestyle Modification Programs in Obese Patients?Vance W. Berger, PhDVance W. Berger, PhDFrom National Cancer Institute, Bethesda, MD 20892.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-151-1-200907070-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The article by Digenio and colleagues (1) has several methodological errors. Can we trust the results of a trial in which patients were randomly assigned inappropriately, patient withdrawals substantially shrank the cohort, the “modified” intention-to-treat analysis did not account for the many patients who withdrew, and the analysis was based on distributional and other assumptions that could not possibly be true? This is a bit hard to swallow.In an unmasked trial, such as this one, the worst form of randomization is permuted blocks—especially with a small, fixed block size (2, 3). With 5 treatments, in this ...References1. Digenio AG, Mancuso JP, Gerber RA, Dvorak RV. Comparison of methods for delivering a lifestyle modification program for obese patients: a randomized trial. Ann Intern Med. 2009;150:255-62. [PMID: 19221377] LinkGoogle Scholar2. Berger VW, Ivanova A, Knoll MD. Minimizing predictability while retaining balance through the use of less restrictive randomization procedures. Stat Med. 2003;22:3017-28. [PMID: 12973784] CrossrefMedlineGoogle Scholar3. Berger VW. Selection Bias and Covariate Imbalances in Randomized Clinical Trials. Chichester, United Kingdom: J Wiley; 2005. Google Scholar Author, Article, and Disclosure InformationAffiliations: From National Cancer Institute, Bethesda, MD 20892.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoComparison of Methods for Delivering a Lifestyle Modification Program for Obese Patients Andres G. Digenio , James P. Mancuso , Robert A. Gerber , and Roman V. Dvorak Do Methodological Flaws Invalidate a Randomized Trial of Lifestyle Modification Programs in Obese Patients? James P. Mancuso , Robert A. Gerber , and Andres G. Digenio Metrics Cited ByAn Application of a New Evidence Grading System to Research on the Chronic Care Model 7 July 2009Volume 151, Issue 1Page: 70KeywordsConflicts of interestForecastingOverweight ePublished: 7 July 2009 Issue Published: 7 July 2009 CopyrightCopyright © 2009 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
TREATMENT OF FRACTURES OF THE CLAVICLE
Authors: H. H. Greenwood
Journal: BMJ (1928)

Apart from the rarity of laryngeal diphtheria. in advanced life the case is of interest in the follow-ing respects.The pernicious doctrine which has received support in two of the most recenit textbooks on diseases of the throat-that anititoxin is of no value after the fiftlh day of disease-is falsified by the rapid subsidence of the symptoms after injection of the large doses which the patient receiv-ed.The abselnce of any serum reaction was due partly to the use of a refined serum and partly to the fact, wlich I have illustrated on several previous occasionis, that serulm reactions are often absenit or ill maiked after severe angina in spite of-the a(lministratioin of 1arge amounts of serum.Recovery was all the more remarkable as the progniosis of larvngeal diphtlheria in adult life is usuially unii- favourable.Lastly the case is an excellent example of what C. Zoeller,3 who has recently recorded an attack of laryngeal diphtheria in a middle-aged man, describes as the " caprices of spontanieouis immunization."
Immunonutrition: Increased mortality is associated with immunonutrition in sepsis
Authors: D. J W Knight
Journal: BMJ (2003)

EDITOR—The review by Calder highlights data from meta-analysis that propose a benefit from giving immunonutrition in critically ill patients,1 but the current literature does not support this.

Recent publications suggest an increase in mortality in patients with sepsis who are given immunonutrition.2 3 Interim analysis of …