tbuckley/cabot-search huggingface dataset:
Predictors of Mortality in Chronic Chagas Disease
Authors: Anis Rassi, Anis Rassi, Sérgio G. Rassi
Journal: Circulation (2007)

Background— Chagas disease is a major cause of morbidity and mortality in Latin America. Knowledge of the predictors of prognosis can help clinical decision making by identifying patients’ level of risk. Methods and Results— We reviewed the published literature on prognostic factors in patients with Chagas disease by performing a PubMed search for articles published in any language between 1985 and February 2006 and hand searches of the reference lists of retrieved articles. Studies were selected if they included patients in the chronic phase of Chagas disease, analyzed a clearly defined outcome (all-cause mortality, sudden cardiac deaths, and/or cardiovascular deaths), and used multivariable regression models of prognosis. From 606 potentially relevant studies, 12 met the inclusion criteria: 8 clinic-based studies including 3928 patients and 4 hospital-based studies including 349 patients. Impaired left ventricular function by echocardiogram or cineventriculogram was found to be the most common and consistent independent predictor of death. New York Heart Association functional class III/IV and cardiomegaly on the chest radiography also were independently associated with higher mortality. More recently, strong evidence was found that nonsustained ventricular tachycardia on 24-hour Holter monitoring indicated an adverse prognosis. The typical ECG abnormalities showed limited additional prognostic value. Other often-mentioned risk factors, advanced age and male sex, showed inconsistent results. A formal meta-analysis was not feasible because of the heterogeneity of published studies and the lack of minimal standards in reporting results. Conclusions— A systematic review of published studies indicates that impaired left ventricular function, New York Heart Association class III/IV, cardiomegaly, and nonsustained ventricular tachycardia indicate a poor prognosis in patients with chronic Chagas disease.
WHO's director general dies
Authors: Michael Day, Tessa Richards
Journal: BMJ (2006)

This week's annual assembly of the World Health Organization has been shaken by the death of its director general, Lee Jong-wook.

Dr Lee, 61, died in Geneva's Cantonal Hospital on Monday, two days after emergency surgery to treat a blood clot on his brain. Born in South Korea, Dr Lee had worked at WHO for 23 years before becoming its head in 2003.

News of his death came as the 192 nation body convened its annual assembly. “I am sorry to tell you that Dr Lee Jong-wook, director general of the WHO, died this morning,” Spain's health minister, Elena Salgado, told the opening session of the assembly.

Ms Salgado, …
Medicine in a Technical Age
Authors: SAMUEL P. ASPER
Journal: Annals of Internal Medicine (1970)

Presidential Address1 August 1970Medicine in a Technical AgeSAMUEL P. ASPER, M.D., F.A.C.P.SAMUEL P. ASPER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-2-325 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMedicine has entered a technical age. At first thought, this statement may appear incongruous at a moment when several hundred of us, wearing caps and gowns, are engaged in a ceremony with tradition hundreds of years old. But this is not an exercise in pedantry or ostentation; it is, in fact, evidence of what I wish to express—that our medicine of today, advancing technologically, is linked firmly to medicine of the past. Further, it serves to remind us for a moment of our rich heritage and of the accomplishments not only of those we honor but also of those who... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland▸Presented April 13, 1970, during the Convocation of Fellows at the 51st Annual Scientific Session of the American College of Physicians, Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1970Volume 73, Issue 2Page: 325-328KeywordsHospital medicineSports and exercise medicine Issue Published: 1 August 1970 PDF DownloadLoading ...
Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.
Authors: M J Saad, F Folli, J A Kahn, C R Kahn
Journal: Journal of Clinical Investigation (1993)

Insulin rapidly stimulates tyrosine kinase activity of its receptor resulting in phosphorylation of its cytosolic substrate, insulin receptor substrate-1 (IRS-1), which in turn associates with phosphatidylinositol 3-kinase (PI 3-kinase), thus activating the enzyme. Glucocorticoid treatment is known to produce insulin resistance, but the exact molecular mechanism is unknown. In the present study we have examined the levels and phosphorylation state of the insulin receptor and IRS-1, as well as the association/activation between IRS-1 and PI 3-kinase in the liver and muscle of rats treated with dexamethasone. After dexamethasone treatment (1 mg/kg per d for 5 d), there was no change in insulin receptor concentration in liver of rats as determined by immunoblotting with antibody to the COOH-terminus of the receptor. However, insulin stimulation of receptor autophosphorylation determined by immunoblotting with antiphosphotyrosine antibody was reduced by 46.7 +/- 9.1%. IRS-1 and PI 3-kinase protein levels increased in liver of dexamethasone-treated animals by 73 and 25%, respectively (P < 0.05). By contrast, IRS-1 phosphorylation was decreased by 31.3 +/- 10.9% (P < 0.05), and insulin stimulated PI 3-kinase activity in anti-IRS-1 immunoprecipitates was decreased by 79.5 +/- 11.2% (P < 0.02). In muscle, the changes were less dramatic, and often in opposite direction of those observed in liver. Thus, there was no significant change in insulin receptor level or phosphorylation after dexamethasone treatment. IRS-1 and PI 3-kinase levels were decreased to 38.6 and 65.6%, respectively (P < 0.01 and P < 0.05). IRS-1 phosphorylation showed no significant change in muscle, but insulin-stimulated IRS-1 associated PI 3-kinase was decreased by 41%. Thus, dexamethasone has differential effects on the proteins involved in the early steps in insulin action in liver and muscle. In both tissues, dexamethasone treatment results in a reduction in insulin-stimulated IRS-1-associated P I3-kinase, which may play a role in the pathogenesis of insulin resistance at the cellular level in these animals.
Bedeutung der Musik für die Tiefenpsychologie
Authors: H.-J. Schumann
Journal: Psychotherapy and Psychosomatics (1956)

Research Articles| February 10 2010 Bedeutung der Musik für die Tiefenpsychologie Subject Area: Psychiatry and Psychology H.-J. Schumann H.-J. Schumann Düsseldorf Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1956) 4 (4): 329–337. https://doi.org/10.1159/000285260 Article history Published Online: February 10 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation H.-J. Schumann; Bedeutung der Musik für die Tiefenpsychologie. Acta Psychotherapeutica et Psychosomatica 1 April 1956; 4 (4): 329–337. https://doi.org/10.1159/000285260 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1956Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Detecting early lung disease in cystic fibrosis: are current techniques sufficient?
Authors: P D Sly
Journal: Thorax (2004)

Use of the multiple breath inert gas washout technique in the early diagnosis of CF

The philosophy underlying treatment at most cystic fibrosis (CF) clinics is essentially preventative—that is, early detection, treatment and hopefully resolutions of problems before they become major clinical issues. The introduction of newborn screening programmes around the world is also based on the idea that early detection and treatment will result in an improved outcome for patients. Progressive lung disease represents the greatest threat to the health and well being of patients with CF. The goal of treatment is to prevent or delay progressive lung disease, so early detection and monitoring of effective treatments would be expected to improve the health and life expectancy of children with CF.

Lung disease in CF is characterised by a progression from bacterial colonisation to mucosal infection and finally invasive infection. This is accompanied by a host inflammatory response characterised by cytokine secretion and influx of neutrophils. The neutrophils appear to be drawn to the lungs largely by a chemotactic protein, interleukin 8 (IL-8), that is found in increased levels in the sputum and lavage of patients with CF.1,2 Increased numbers of neutrophils result in increased levels of the products of activated neutrophils such as neutrophil elastase (NE). Unbound NE is thought to be responsible for much of the lung damage seen in CF.3 Breakdown products of elastin found in the urine of patients with CF are thought to originate in the lung,3 indicating that lung destruction is occurring.

Recent studies provide strong evidence that lung disease begins during early life in most children with CF. Bronchoalveolar lavage (BAL) performed in infants and young children with CF shows evidence of inflammation and …
Respiratory Viruses and Mycoplasma as Cofactors for Epidemic Group A Meningococcal Meningitis
Authors: Patrick S. Moore
Journal: JAMA (1990)

To investigate the role of coincident respiratory viral and mycoplasmal agents in the pathogenesis of meningococcal meningitis, we performed a matched case-control study of 62 patients with group A meningococcal meningitis during an epidemic in Chad. Case patients were more likely than controls to have nasal colonization or infection with respiratory viruses and Mycoplasma species (matched odds ratio, 23; 95% confidence interval, 3.1 to 170). Respiratory pathogens were found more commonly in older patients with meningitis (odds ratios were 2.9 for children under age 5 years and 46.5 in those over age 15 years), consistent with the increasing risk of meningitis with age during epidemics. In controls, the presence of respiratory pathogens increased the risk of upper-respiratory-tract symptoms but did not significantly increase meningococcal carriage.
HLA class I allelic diversity and progression of fibrosis in patients with chronic hepatitis C
Authors: Keyur Patel, Suzanne Norris, Lauralynn Lebeck, Anne Feng, Michael Clare, Stephen Pianko, Bernard Portmann, Lawrence M. Blatt, James Koziol, Andrew Conrad, John G. McHutchison
Journal: Hepatology (2006)

Patients infected with HIV-1 who are heterozygous at HLA class I loci present greater variety of antigenic peptides to CD8+ cytotoxic T lymphocytes, slowing progression to AIDS. A similar broad immune response in chronic hepatitis C (CHC) infection could result in greater hepatic injury. Although specific HLA class II alleles may influence outcome in CHC patients, the role of HLA class I heterogeneity is generally less clearly defined. Our aims were to determine whether HLA class I allelic diversity is associated with disease severity and progression of fibrosis in CHC. The study population consisted of 670 adults with CHC, including 155 with advanced cirrhosis, and 237 non-HCV-infected controls. Serological testing for HLA class I antigens was performed via microlymphocytotoxicity assay. Peptide expression was defined as heterozygous (i.e., a different allele at each locus) or homozygous. Fibrosis staging was determined using METAVIR classification. Heterozygosity at the B locus (fibrosis progression rate [FPR] 0.08 vs. 0.06 units/yr; P = .04) and homozygosity at the A locus (FPR 0.10 vs. 0.08 units/yr; P = .04) predicted a higher median FPR. Age at infection, genotype, and duration of infection were also predictors of FPR. A higher proportion of patients with stage F2-F4 expressed HLA-B18 compared with controls (OR 2.2, 95% CI 1.17-4.23; P = .02). These differences were not observed in patients with advanced cirrhosis. HLA zygosity at 1, 2, or 3 alleles was not associated with fibrosis stage, liver inflammation, or treatment outcome. In conclusion, HLA class I allelic diversity has a minor influence on FPRs and disease severity in CHC.
CHRONIC URTICARIA AND ANGEIO - NEUROTIC ŒDEMA DUE TO BACTERIAL SENSITISATION
Authors: H. W. BARBER
Journal: British Journal of Dermatology (1923)

Journal Article CHRONIC URTICARIA AND ANGEIO ‐ NEUROTIC ŒDEMA DUE TO BACTERIAL SENSITISATION Get access H. W. BARBER, M.D., F.R.C.P. H. W. BARBER, M.D., F.R.C.P. Physician in Charge of the Skin Department, Guy's Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 35, Issue 6, 1 June 1923, Pages 209–218, https://doi.org/10.1111/j.1365-2133.1923.tb09109.x Published: 01 June 1923
Standardization of allergen products: 1. Detailed characterization of GMP‐produced recombinant Bet v 1.0101 as biological reference preparation
Authors: M. Himly, E. Nony, H. Chabre, L. Van Overtvelt, A. Neubauer, R. Van Ree, K.‐H. Buchheit, S. Vieths, P. Moingeon, F. Ferreira
Journal: Allergy (2009)

Background: Standardization of allergen extracts requires the availability of well‐characterized recombinant allergens, which can be used as reference standards provided by the European regulatory authorities. The objective of this study was the detailed physicochemical and immunological characterization of rBet v 1.0101, which shall be used in a ring trial within the framework of the Biological Standardization Programme BSP090 of the European Directorate for Quality of Medicines and Healthcare. Methods: Recombinant Bet v 1.0101 Y0487 was produced under good manufacturing practice conditions and analysed by an array of physicochemical and immunological methods for identity, quantity, homogeneity, folding and denaturation, aggregation state and stability in solution, as well as biological activity. Results: Batch Y0487 was shown to contain monomeric and well‐folded protein being identical with rBet v 1.0101, as determined by mass spectrometry. SDS‐PAGE, isoelectric focusing, deamidation analysis and size‐exclusion chromatography with light scattering revealed sample homogeneity of &gt;99.9%. Upon storage at +4°C batch Y0487 retained the monomeric state up to 3 months. Protein quantification determined by amino acid analysis was found coinciding with half‐maximal inhibition of serum IgE in ELISA. Biological activity of batch Y0487 was shown to be comparable to natural Bet v 1 by IgG and IgE immunoblotting, as well as basophil and T‐cell activation. Conclusion: Recombinant Bet v 1.0101 Y0487 was characterized extensively by physicochemical and immunological methods. It was shown highly stable, monomeric and immunologically equivalent to its natural counterpart. Thus, it represents an appropriate candidate reference standard for Bet v 1.
Evidence for redifferentiation of human chondrocytes grown on a hyaluronan-based biomaterial (HYAFF®11): molecular, immunohistochemical and ultrastructural analysis
Authors: Brunella Grigolo, Gina Lisignoli, Anna Piacentini, Mauro Fiorini, Pietro Gobbi, Giovanni Mazzotti, Manuela Duca, Alessandra Pavesio, Andrea Facchini
Journal: Biomaterials (2002)
Faster . . . but Fast Enough? Responding to the Epidemic of Severe Acute Respiratory Syndrome
Authors: Julie Louise Gerberding
Journal: New England Journal of Medicine (2003)

Severe acute respiratory syndrome (SARS) was diagnosed in more than 1800 patients in 17 countries (including the United States and Canada) between February 1 and March 31, 2003. During this two-month period, the World Health Organization (WHO) coordinated an international investigation that has produced unprecedented scientific and epidemiologic discoveries with unprecedented speed. On March 12, the WHO issued a global alert about SARS. On March 14, the Centers for Disease Control and Prevention (CDC) activated its emergency operations center to support the response of the WHO to this global threat. Within 24 hours of the official invitations, CDC investigators joined . . .
The liver in hereditary haemorrhagic teleangiectasia: an inborn error of vascular structure with multiple manifestations: a reappraisal.
Authors: G A Martini
Journal: Gut (1978)

Hereditary haemorrhagic teleangiectasia (Rendu-Osler-Weber disease) is an inborn error of vascular structure with multiple manifestations. Its incidence is about 1-2:100 000 in the European population. The incidence of telangiectases and/or fistula formation was estimated to be 1 in 10 carriers of the Osler trait. The findings in the family reported herewith suggest a much higher incidence if angiography is more frequently performed. Apart from the skin and mucous membrane, teleangiectases and/or arteriovenous fistulas may be present in the lungs, intestinal tract, spleen, kidney, brain, and bones. The liver apparently is more involved than was orginally suspected. The vascular derangement includes teleangiectases, arteriovenous fistulas, and connective tissue formation with fibrosis and atypical cirrhosis. In intestinal bleeding laser coagulation seems to be very efficient. The pathogenesis of teleangiectases is not known but involves several factors such as special formation of venules, capillaries and arterioles, abnormal perivascular connective tissue and endothelial cells.
Hepatocellular carcinoma composed of two different histologic types: imaging features on gadoxetic acid-enhanced liver MRI
Authors: Seung Hyun Kim, Woo Kyoung Jeong, Yongsoo Kim, Min Yeong Kim, Jinoo Kim, Ju Yeon Pyo, Young Ha Oh
Journal: Clinical and Molecular Hepatology (2013)

Keywords: Hepatocellular carcinoma; Magnetic resonance imaging; Gadoxetic acid; Gd-EOB-DTPA; Pseudoglandular type
CONGENITAL HYPERTROPHIC STENOSIS OF THE PYLORUS: AN ANALYSIS OF 145 CASES TREATED BY OPERATION
Authors: H. L. Wallace, L. B. Wevill
Journal: BMJ (1934)

In this paper an analysis has been made of 145 cases of congenital hypertrophic stenosis of the pylorus which have been treated by operation at the Royal Edinburgh Hospital for Sick Children during the twelve-year period 1922 to 1933 inclusive.In every case a positive diag- nosis of pyloric stenosis was confirmed at operation, and no doubtful cases -have been included in the series.Those treated by medical measures only, such as repeated gastric lavage, are not considered, although in a large proportion of the series treatment had been carried out in the medical wards prior to operation, with a view to improving the general condition of the patient.It is not proposed to discuss in detail the symptomatology of congenital pyloric stenosis, but merely -to analyse the results of treatment in this series of hospital cases.Sex and Age Incidence Out of the total of 145 cases 125 were males and twenty females, representing a preponderance of males over females of 6.25 to 1.The 1931 census figures for 35r wI '.3 VI I GRAI'H 1.--Showing age on admission and age at first symptom for the total cases.
Chlorthenoxazin--a New Analgesic
Authors: D. Wilson, P. H. Kendall, P. M. Pawsey
Journal: BMJ (1960)

IRRADIATION OF THYMUS GLANDB jouM collected before any definite statement can be made concerning the risk throughout the subsequent life of these patients. SummaryThirty-two patients who received irradiation for suspected thymic enlargement in infancy between 1932 and 1950 are reviewed.Thirty-one of these have been traced.Three have died, one possibly from the acute effects of the radiation.One case developed a nodular goitre 22 years after the irradiation, another had slight diffuse enlargement of the thyroid at the age of 17, and another had a neurilemmoma removed from the neck at the age of 14.There were no cases of leukaemia.I thank Professor Alan Moncrieff, on whose suggestion
Increased leukotriene B4 release from ileal pouch mucosa in ulcerative colitis compared with familial adenomatous polyposis.
Authors: D J Gertner, D S Rampton, M V Madden, I C Talbot, R J Nicholls, J E Lennard-Jones
Journal: Gut (1994)

Pouchitis may complicate the construction of an ileal pouch after colectomy for ulcerative colitis (UC) but not familial adenomatous polyposis (FAP). To examine whether differences in eicosanoid metabolism might explain why pouchitis is largely confined to UC patients, this study compared arachidonic acid stimulated release of immunoreactive leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) from macroscopically uninflamed pouch mucosal biopsy specimens incubated in vitro from patients with UC and FAP. The study also compared eicosanoid release from inflamed and uninflamed pouches in patients with UC. In uninflamed pouches, median LTB4 release was nearly twice as high in UC as in FAP (p = 0.001), but there was no significant difference in PGE2 production. In UC, stimulated eicosanoid release from uninflamed functioning pouch mucosa was not significantly different from that from either ileostomy or defunctioned pouch mucosa. LTB4 and PGE2 release were significantly greater from inflamed than uninflamed pouch mucosa in UC (p = 0.001 and 0.01, respectively). Leukotriene synthesis inhibition or receptor antagonism, or both merit therapeutic evaluation in pouchitis. Increased release of LTB4 from endoscopically normal pouch mucosa suggests increased 5-lipoxygenase activity in patients with UC and could contribute to their predisposition to pouchitis.