Sickle Cell Hemoglobin D Disease in a Negro Colombian Patient
Authors: ALBERTO M. RESTREPO
Journal: Annals of Internal Medicine (1965)

Case Studies1 June 1965Sickle Cell Hemoglobin D Disease in a Negro Colombian PatientALBERTO M. RESTREPO, M.D., OSCAR G. LONDOÑO, M.D.ALBERTO M. RESTREPO, M.D.Search for more papers by this author, OSCAR G. LONDOÑO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-6-1301 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSickle cell hemoglobin D disease, sometimes referred to as drepanocytosis hemoglobin D disease or hemoglobin S-D disease, was described initially by Itano (1) in 1951. Since that time only seven additional cases of this disease have been reported (2-8).The present study describes the findings in an additional patient with sickle cell hemoglobin D disease.METHODSRoutine hematological studies were performed. Other methods included paper electrophoresis with veronal buffer at a pH of 8.6, electrophoresis on agar gel with citrate buffer at a pH of 6.0 (9), sickle cell preparation with 2% sodium metabisulphate (10), hemoglobin solubility in 2.8M...References1. ITANO HA: A third abnormal hemoglobin associated with hereditary hemolytic anemia. Proc. Nat. Acad. Sci. USA 37: 775, 1951. CrossrefMedlineGoogle Scholar2. DACIE JV: Haemolytic Anaemias. Congenital and Acquired. Churchill, London, 1954, p. 146. Google Scholar3. STURGEONITANOBERGREN PHAWR: Clinical manifestations of inherited abnormal hemoglobins. I. The interaction of hemoglobins S with hemoglobin D. Blood 10: 389, 1955. CrossrefMedlineGoogle Scholar4. STEWARTMACIVER JWJE: Sickle cell haemoglobin D disease in a mulatto girl. The Lancet 1: 23, 1956. CrossrefGoogle Scholar5. SMITHCONLEY EWCL: Sickle cell hemoglobin D disease. Ann. Intern. Med. 50: 94, 1959. LinkGoogle Scholar6. ARENDSLAYRISSEROMERO TMRA: Sickle cell haemoglobin D disease in a Portuguese child. Acta. Haemat. (Basel) 22: 118, 1959. CrossrefMedlineGoogle Scholar7. MCCURDY PR: Clinical and physiologic studies in a Negro with sickle-cell hemoglobin D disease. New Eng. J. Med. 262: 961, 1960. CrossrefGoogle Scholar8. FIGUEROAARENDS ET: Enfermedad por drenapanocitosis y hemoglobina D complicada con anemia megaloblastica en un niño Venezolano. Arch. Venez. Pueric. Pediat. 26: 494, 1963. Google Scholar9. MARDERCONLEY VL: Electrophoresis of hemoglobin on agar gells. Bull. Hopkins Hosp. 105: 519, 1963. Google Scholar10. DALANDCASTLE SAWB: A simple and rapid method for demonstrating sickling of the red blood cells and the use of reducing agents. J. Lab. Clin. Med. 33: 1082, 1949. Google Scholar11. FRIEDMAN HS: A rapid screening test for abnormal hemoglobins. Clin. Chim. Acta 7: 100, 1962. CrossrefMedlineGoogle Scholar12. ECHAVARRIAMOLINA AC: Un nuevo metodo de electroforesis en gel de agar para la separacion de las hemoglobinas y en especial para la hemoglobina A2. Antioquia Med. 13: 507, 1963. Google Scholar13. TONDOSALZANO CVFM: Abnormal hemoglobins in a Brazilian Negro population. Amer. J. Hum. Genet. 14: 401, 1962. MedlineGoogle Scholar14. RESTREPO MA: Hemoglobinas anormales y talasemia. Antioquia Med. 13: 580, 1963. Google Scholar15. ARENDS T: Frecuencia de las hemoglobinas anormales on Venezuela. Arch. Hosp. Vargas 3: 225, 1961. Google Scholar16. WEATHERALLSIGLERBAGLIONI DJATE: Four hemoglobins in each of three brothers. Genetic and biochemical significance. Bull. Hopkins Hosp. 111: 143, 1962. MedlineGoogle Scholar17. ATWATERSCHWARTZTOCANTINS JIRLM: A variety of human hemoglobin with four electrophoretic components. Blood 14: 901, 1960. CrossrefGoogle Scholar18. RAPERGAMMOCKHUEHNSSHOOTER ABDBEREM: Four haemoglobins in one individual. A study of the genetic interaction of haemoglobin G and haemoglobin C. Brit. Med. J. 2: 1257, 1960. CrossrefMedlineGoogle Scholar19. LEHMANNWOKOLO HC: The River Nile as a barrier in the spread eastward of haemoglobin C. A survey of haemoglobins in the Ibo. Nature (London) 183: 1583, 1959. Google Scholar20. WEATHERALLBOYER DJSH: Evidence for the genetic identity of alpha chain determinants in Hemoglobins A, A2 and F. Bull. Hopkins Hosp. 110: 8, 1962. MedlineGoogle Scholar21. MCCURDYPEARSONGERALD PRHPS: A new hemoglobinopathy of an usual genetic significance. J. Lab. Clin. Med. 58: 86, 1961. Google Scholar22. MINNICHCORDONNIERMOORE VJKCV: Alpha, beta and gamma hemoglobin polypeptide chains during the neonatal period with a description of a fetal form of hemoglobin D St. Louis. Blood 19: 137, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Medellin, ColombiaFrom the Department of Medicine, School of Medicine, Universidad de Antioquia, Medellin, Colombia.Requests for reprints should be addressed to Alberto M. Restrepo, M.D., Chief, Hematology, Department of Internal Medicine, School of Medicine, Universidad de Antioquia, Medellin, Colombia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLife-Twieatening Complications in a Child with Hemoglobin Sd-Los Angeles DiseaseHaemoglobin D Punjab (D Los Angeles)Aseptic necrosis of the femoral head in a white boy with S-D hemoglobinopathyNeurological Manifestations in Sickle-Cell Disease With a Review of the Literature and Emphasis on the Prevalence of HemiplegiaBARRY A. PORTNOY, M.D., JOHN C. HERION, M.D.Haemoglobin S-D Disease in a Turkish FamilyHemoglobin S-D DiseaseM. J. CAWEIN, M.D., E. J. LAPPAT, M.D., R. W. BRANGLE, M.D., C. H. FARLEY, M.D. 1 June 1965Volume 62, Issue 6Page: 1301-1306KeywordsBiologicsGel electrophoresisHematology and oncologyHemoglobinHemolytic anemiaNeutrophilsPaper electrophoresisSickle cell diseaseSickle cell hemoglobinSodium Issue Published: 1 June 1965 PDF downloadLoading ...