tbuckley/cabot-search huggingface dataset:
The Lloyd Roberts Lecture ON THE RENAISSANCE OF MIDWIFFERY
Authors: H. R. Spencer
Journal: BMJ (1924)

that the Medical Society was perhaps influenced in its choice of a lecturer this year by the facts that he enjoyed Lloyd Roberts's intimate friendship during the last twenity-five years of his life, that they were fellow workers in the same field of medicine, and that the same subjects, especially old bboks, interested them both.By way of commemorating the founder of these lectures, Dr. Herbert Spencer then gave some particulars of David Lloyd Roberts's personalitv, character, and habits from his own experience, and some particulars of the earliest books on midwifery in which hle was especially interested and of which he bequeathed to the 'Royal College of Physicians such an unexampled collectioni.
Screen for Chlamydia
Authors: Brian Vastag
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The decay of the potentiated state in sheep and calf ventricular myocardial fibers. Influence of agents acting on transmembrane Ca2+ flux.
Authors: O Bass
Journal: Circulation Research (1976)

Paired pulse stimulation increases the contractile strength of mammalian myocardium. If stimulation is discontinued the "potentiated state" takes several minutes to decay, as shown by the first contraction following resumption of stimulation. From earlier experiments it has been inferred that contractile force depends on Ca2+ released from intracellular stores rather than on an influx of Ca2+ associated with a given action potential. This view now receives support from the following findings: (1) Ni2+ and Co2+, known to inhibit Ca2+ influx during the action potential, when applied during a 2-minute rest period, are practically without effect on the strength of the first beat but strongly depress steady state contractions. (2) Caffeine, known to enhance Ca2+ efflux from and inhibit Ca2+ uptake into intracellular stores, greatly accelerates the decay of the potentiated state during a rest period. (3) Na+ -poor solution, known to inhibit Ca2+ efflux, has a strong positive inotropic effect. Paired pulse stimulation fails to increase contractile strength in Na+ -poor solution, and a rest period of many minutes is practically without effect on the amplitude of the first beat after resumption of stimulation. The results indicate that contraction is due to Ca2+ released from internal stores whose degree of filling can be altered.
Trimethoprim and Sulphamethoxazole
Authors: Z. Farid
Journal: BMJ (1971)

used the discovery of staphylococcuskilling products of a fungus to make penicillin which saved millions of lives.Other scientists used the principle of atomic fission to make weapons and bombs.Two of these bombs were dropped in Japan, and killed over 2 million people, and horribly crippled many more, in seconds.Some of the machines invented or made by scientists now spew out pollutants into the air and waters."This, I believe, is the greatest contribution leading scientists can make to the wel- fare of mankind-to admit failures as readily as they admit apparent successes.-Iam, etc., C. DE F. W. GOONARATNA Dundee Anorexia Nervosa SIR,-In the leading article on anorexia nervosa (23 October, p. 183) you state "Though doubts have been expressed about its status as a distinct entity, it is generally regarded as a consistent syndrome."I have been-trying without success to fathom what this means.I think I know what a con- sistent syndrome is; but I have no idea what is meant by "distinct entity," nor how one would decide whether or no "a consistent syndrome" is "a distinct entity."Could you enlighten me ?-I am, etc.,
Foundations for Medical Care
Authors: Richard H. Egdahl
Journal: New England Journal of Medicine (1973)

Abstract Foundations for Medical Care are management systems for health-services delivery, set up and run by physicians. "Claims-review" Foundations for Medical Care restrict themselves to peer-review activities consisting of reviewing payment claims that fall outside of established norms and are referred by fiscal intermediaries. "Comprehensive" Foundations for Medical Care, on the other hand, set minimum benefits packages and process all patient-services payment claims for peer review when appropriate. Significant cost reductions have been demonstrated by comprehensive Foundation peer review. Additional savings have been realized by adding hospital certification to the process. Some comprehensive Foundations have assumed a portion of the underwriting risk for a defined population and have provided comprehensive health services for a fixed annual sum on a capitation basis, thereby qualifying as Health Maintenance Organizations. Foundations for Medical Care have potential as a cost-effective management mechanism for the delivery of health services with a high level of quality assurance.
A POCKET-CARD FOR THE EASY CALCULATION OF MILK-MIXTURES
Authors: J. P. Crozer Griffith
Journal: JAMA (1918)

The evident need of a simplification of the procedures required for the prescribing of milk-formulas of known strengths in infant feeding has led to the devising of numerous ready methods. One which, emanating from Germany, has had a decided vogue in parts of this country during the last few years has been denominated the method of the "simple dilution" of whole milk. It probably owes its origin to Heubner, and has much in its favor. It should be at once understood, however, that, contrary to a widespread opinion, it in no sense does away with the calculation of percentages, since it was intended to be employed in conjunction with the estimation of the caloric value of the milk-mixture used; and this, of course, cannot be done unless the percentage composition of the food is known. In fact, it is an impossibility to prepare a milk-formula in a way which offers
Diagnostic Tests for Sexually Transmitted Disease
Authors: Peter E. Dans
Journal: JAMA (1976)

To  Editor.—  Sensitivity has been defined as the percent of positive results in  with   and specificity as the percent of negative results among people who do not have   1 In  article Efficacy of Selected Diagnostic Tests for Sexually Transmitted Diseases (235:49, 1976),  authors equated positive cultures and  with disease. If we assume that patients with  refers to those in whom therapeutic intervention is indicated, isolation of  gonococcus can be considered to be an indicator of disease whether or not  patient has signs or symptoms. However,  isolation of Candida may merely represent colonization and may neither imply its etiology in any vaginitis nor require therapy.  Furthermore, even for gonorrhea,  sensitivity of  culture techniques, even in  best of circumstances, is not 100%. This is especially true for anal canal and endocervical specimens. Repetitive testing with multiple
Down From Troy
Authors: Tony Miksanek
Journal: JAMA (1992)

<i>Down From Troy</i>is ostensibly Richard Selzer's account of growing up in Troy, NY. It is, however, a book very interested in pain and Selzer's quest to heal wounds both as a surgeon and a writer. In reconstructing his youth, the author adulterates this book with tender sentiments of aging. The result is nonetheless an impressionistic masterpiece. Pain is a major theme of the work, and Selzer chronicles its many forms: the suffering of an entire town during the Depression, the hurt of scorned adolescent love, the distress of a malpractice suit, the misery of a father's death, the ache of learning one's parents no longer love each other, and the pain of growing up. It is only through infinite forms of love that such pain is confronted, even when it cannot be squelched. Selzer's introduction to suffering comes early. As a youth living above his GP father's office, he
GMC clears research dean of dishonesty
Authors: C. Dyer
Journal: BMJ (2009)

<h3>Background</h3> Inflammation and vascular disease have recently been shown to play a role in the pathogenesis of osteoarthritis (OA). Low dose aspirin is commonly used in the prevention of cardiovascular disease. Its effects have been attributed to a variety of actions, including anti-inflammatory effects and effects on platelet function (both anti-thrombotic and anti-inflammatory) and lipids. However whether it affects human joints has not been studied. <h3>Objectives</h3> The aim of this study was to examine whether the use of low dose aspirin affects change in knee cartilage volume over 2 years. <h3>Methods</h3> 117 people with symptomatic knee OA underwent magnetic resonance imasging of the knee at baseline and 2 years later. Medial and lateral tibial cartilage volumes were measured using validated methods. Annual absolute change and annual percentage change in cartilage volume were calculated. Information about regular low dose aspirin use was collected at baseline, 6, 12 and 24 months. Participants who reported taking regular low dose aspirin (≤ 150 mg per day) at more than 1 time point were defined as being aspirin users. <h3>Results</h3> Twenty six participants reported taking aspirin at more than one visit, with 91 not taking aspirin. At baseline, the only significant difference between the 2 groups was that those taking aspirin were older than those who did not (p = 0.03). In those taking aspirin, annual change in medial tibial cartilage volume and annual percentage change in cartilage volume was approximately half that seen in those not taking aspirin (-50 vs. -102 mm<sup>3</sup> and -2.5% vs. -5.5%, respectively, P=0.04 for both). These differences became more significant after adjusting for age, gender, body mass index, initial cartilage volume and severity of radiographic change in the medial compartment. The annual change in medial tibial cartilage volume was -40 mm<sup>3</sup> (95% confidence interval (CI) -83, 1.3) in aspirin users vs. -105 mm<sup>3</sup> (95% CI -127, -82) in non-aspirin users (P = 0.009 for difference). The annual percentage change in medial tibial cartilage volume was -2.0% (95% CI -4.6, 0.53) in aspirin users vs. -5.6% (95% CI -6.9, -4.0) in non-aspirin users (P=0.02 for difference). There were no significant differences observed in change in lateral tibial cartilage volume. <h3>Conclusions</h3> This study showed that in people with knee OA, the use of low dose aspirin was associated with reduced medial tibial cartilage loss over 2 years. This requires confirmation in a randomised controlled trial. If this hypothesis were proven, aspirin may provide a cost effective disease modifying therapy for OA as it is a cheap medication that is already in common use and known to be well tolerated. <h3>Disclosure of Interest</h3> None Declared
Superior Vena Cava Obstruction as Suggested by Extrapulmonary Uptake on Lung Scintigraphy
Authors: Zarni Win, Jonathan Todd, Adil Al-Nahhas, W E. Svensson
Journal: Clinical Nuclear Medicine (2006)

The authors present a case of a 79-year-old woman who was admitted with acute shortness of breath and pleuritic chest pain. A diagnosis of pulmonary emboli was made on lung scintigraphy (VQ scan). However, further imaging, which led to the eventual diagnosis of SVC obstruction, was made only after detecting abnormal extrapulmonary tracer accumulation. Understanding the significance of extrapulmonary uptake on lung scintigraphy is vital in appreciating the development of venous collaterals in superior vena cava obstruction.
The effect of the composition of PLA films and lactate release on glial and neuronal maturation and the maintenance of the neuronal progenitor niche
Authors: Zaida Álvarez, Miguel A. Mateos-Timoneda, Petra Hyroššová, Oscar Castaño, Josep A. Planell, José C. Perales, Elisabeth Engel, Soledad Alcántara
Journal: Biomaterials (2012)
Microvascular Function Is Selectively Impaired in Patients With Hypertrophic Cardiomyopathy and Sarcomere Myofilament Gene Mutations
Authors: Iacopo Olivotto, Francesca Girolami, Roberto Sciagrà, Michael J. Ackerman, Barbara Sotgia, J. Martijn Bos, Stefano Nistri, Aurelio Sgalambro, Camilla Grifoni, Francesca Torricelli, Paolo G. Camici, Franco Cecchi
Journal: Journal of the American College of Cardiology (2011)
Eighty-Five Not Out: Essays to Honour Sir George Godber
Authors: D Acheson
Journal: BMJ (1994)

Ed Stephen Lock King Edward's Hospital Fund for London, pounds sterling5, pp 78 ISBN 1–85717–071–7

This brief collection of essays from a seminar celebrating the 85th birthday of Sir George Godber contains more ideas about the National Health Service than many heavy tomes. Although the emphasis is on how the present can inform the future, the book's perspective matches the scale of Sir George's career in government. This started in the pre- war pre-NHS Ministry of Health and extended over a third of a century until 1973, when he retired after 13 years as Chief Medical Officer. Judging by his own contribution to the seminar, entitled “Medicine in society now and in the future,” the Mount Godber volcano is still far from extinct. It is therefore right and proper that in this review his reflections on …
FATE OF MUMPS VIRUS IN THE EMBRYONATED EGG AS DETERMINED BY SPECIFIC STAINING WITH FLUORESCEIN-LABELLED IMMUNE SERUM
Authors: Barbara K. Watson
Journal: The Journal of Experimental Medicine (1952)

Specific staining with fluorescein-labelled immune serum was used to study the progress of mumps virus infection in a series of embryos harvested at daily intervals. The results were compared with the hemagglutinin and infectivity titers of the corresponding extraembryonic fluids. The evidence obtained indicated that the multiplication of the virus was restricted to those cells which came into surface contact with infected fluid. Following intraamniotic inoculation into 8 day old embryos, these included the cells lining the amniotic membrane and the epidermal and pharyngeal epithelium. Depending apparently on the extent of the contamination of the allantoic cavity and of the extraembryonic celom in the course of inoculation, varying amounts of virus were also present in the cells lining the chorioallantoic membrane and occasionally in the peritoneum. During the later stages of the infection, staining which was principally if not entirely extracellular was seen in the gastrointestinal tract, and, after the dissolution of the tracheal plug, in the respiratory tract. The virus was first detected 1 to 2 days after inoculation as brightly fluorescent intracytoplasmic granules of varying size. As these granules increased in size and number they gradually filled the cytoplasm of the outer one or two layers of cells lining the adjoining cavity. The extent and brightness of the staining reached a peak 4 to 6 days after inoculation and thereafter decreased progressively. The staining of the tissues closely paralleled the rise and fall in the infectivity of the extraembryonic fluids. The development of hemagglutinins, on the other hand, provided a less sensitive measure of virus multiplication than did the staining. No differences were detected in the mortality of the infected and control series of embryos nor was there evidence of any pathological changes. In contrast to the 8 day old embryos, no virus multiplication was detected following the inoculation of 16 day old embryos.
The feasibility of detecting His-bundle activity from the body surface
Authors: A. FURNESS, G. P. SHARRATT, P. CARSON
Journal: Cardiovascular Research (1975)

Journal Article The feasibility of detecting His-bundle activity from the body surface Get access ANTHONY FURNESS, ANTHONY FURNESS From the Cardiac Department of the North Staffs Hospital Group, Stoke-on-Trent Search for other works by this author on: Oxford Academic PubMed Google Scholar GEOFFREY P. SHARRATT, GEOFFREY P. SHARRATT From the Cardiac Department of the North Staffs Hospital Group, Stoke-on-Trent Search for other works by this author on: Oxford Academic PubMed Google Scholar PETER CARSON PETER CARSON From the Cardiac Department of the North Staffs Hospital Group, Stoke-on-Trent Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 9, Issue 3, May 1975, Pages 390–396, https://doi.org/10.1093/cvr/9.3.390 Published: 01 May 1975
Endothelin-1-induced vasoconstriction causes a significant increase in portal pressure of rat liver: Localized constrictive effect on the distal segment of preterminal portal venules as revealed by light and electron microscopy and serial reconstruction
Authors: Kenji Kaneda, Wichai Ekataksin, Mitsue Sogawa, Akiko Matsumura, Akikuni Cho, Norifumi Kawada
Journal: Hepatology (1998)

Intraportal infusion of endothelin-1 (ET-1), a potent vasoconstrictor, significantly elevates portal venous pressure. To determine the major site of vascular constriction in the intrahepatic porto-sinusoidal system, we performed an in situ perfusion of rat livers with 1 nmol/L ET-1 at a flow rate of 20 mL/min. Portal pressure rose from 22 cm H2O to 54 cm H2O within 25 minutes. Specimens were prepared for light-microscopic serial reconstruction and electron microscopy. The distal segment of preterminal portal venules (DS/PPV) with an inner diameter of 40 to 80 microm showed complete obliteration of the lumen over a 300-microm distance caused by the intense contraction of perivascular smooth muscle cells and protruding of endothelial cells into the lumen. The proximal segment of preterminal portal venules (PS/PPV) with a larger diameter up to 150 microm also underwent strong constriction, but still had luminal space for the flow, while the PS/PPV with a diameter of 150 to 400 microm showed moderate or mild constriction and retained a wide lumen. Neither terminal portal venules, inlet venules, sinusoids, nor central veins, however, exhibited demonstrable constriction. Liver parenchyma fed by the inlet venules that emerged from the PS/PPV exhibited a wide sinusoidal lumen and vacuolated hepatocytes caused by the influx of excess portal perfusate that escaped from the occlusive areas. The present study has revealed that the DS/PPV functions as a presinusoidal quasi-sphincter mechanism and is involved in the redistribution of intrahepatic portal flow under increased portal pressure.
Insulin Growth Factor-Receptor (IGF-1R) Antibody Cixutumumab Combined with the mTOR Inhibitor Temsirolimus in Patients with Refractory Ewing's Sarcoma Family Tumors
Authors: Aung Naing, Patricia LoRusso, Siqing Fu, David S. Hong, Pete Anderson, Robert S. Benjamin, Joseph Ludwig, Helen X. Chen, Laurence A. Doyle, Razelle Kurzrock
Journal: Clinical Cancer Research (2012)

Temsirolimus was combined with cixutumumab, a fully human IgG1 monoclonal antibody directed at the insulin growth factor-1 receptor (IGF-1R).
SURVIVAL BENEFIT OF THE PRIMARY PREVENTION IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR AMONG OLDER PATIENTS: DOES AGE MATTER? A PATIENT-LEVEL META-ANALYSIS OF 5 CLINICAL TRIALS
Authors: Paul L. Hess, Sana Al-Khatib, Joo Y. Han, Rex Edwards, Gust Bardy, J. Thomas Bigger, Alfred Buxton, Riccardo Cappato, Paul Dorian, Al Hallstrom, Alan Kadish, Peter Kudenchuk, Kerry Lee, Daniel Mark, Arthur Moss, Richard Steinman, Lurdes Inoue, Gillian Sanders
Journal: Journal of the American College of Cardiology (2014)
LACTOFERRIN, AN IRON-BINBING PROTEIN NI NEUTROPHILIC LEUKOCYTES
Authors: P. L. Masson, J. F. Heremans, E. Schonne
Journal: The Journal of Experimental Medicine (1969)

Lactoferrin, an iron-binding protein previously shown to occur in many external secretions, is identified as one of the major proteins present in human and guinea pig neutrophilic polymorphonuclear leukocytes. The identification of this protein in leukocyte extracts was based upon a comparison of its electrophoretic, antigenic, and iron-combining properties with the corresponding properties of the same protein isolated from human and guinea pig milk. Immunochemical quantitations showed that lactoferrin occurs in human neutrophilic leukocytes at the concentration of 3 microg per 10(6) cells. Tissue cultures from guinea pig bone marrow and spleen actively synthesized the protein, as shown both by net production of lactoferrin and incorporation of labeled amino acids into the protein. Immunohistochemical data indicate that lactoferrin first appears in myeloid cells at the stage of the promyelocyte.
Cortisone in Rheumatic Carditis: Some Preliminary Observations
Authors: E. N. Chamberlain, J. D. Hay, D. M. Freeman
Journal: BMJ (1952)

The dramatic and immediate results achieved in the treatment of rheumatoid arthritis by the use of cortisone and A.C.T.H. was followed by observations on other forms of arthritis, among them rheumatic.fever.Several claims have been made for the beneficial influence of these drugs upon the articular manifesta- tions, pyrexia, and raised sedimentation rate found in acute rheumatism.It was naturally hoped that the preparations might exert a beneficial effect upon the cardiac muscle and fibrous valves affected by rheumatic fever similar to that upon the skeletal muscles and fibrous tissue in rheumatoid arthritis.These hopes were expressed by Hench, Slocumb, et al. (1949), who treated three cases of rheumatic fever, noting a rapid disappearance of fever, tachycardia, and arthralgia.The E.S.R. became normal within three to four weeks.They fur- ther observed electrocardiographic evidence of improve- ment.Thus the P-R interval, which was prolonged in two cases, returned to normal within a week, and in one case the RS-T and the T wave changes disappeared in 26 days.The clinical manifestations of carditis in their cases do not appear to have been convincing, and the authors were well aware of this though they hoped that cortisone might favourably influence the course of rheumatic carditis.Further, they thought that the effects of cortisone on other manifestations of rheuma- tic fever were superior to those obtained by salicylates or in cases allowed to run a natural course.Later work by the same authors seemed to support their original claims (Hench, Kendall, et al., 1950).Barnes and Smith (1950) also treated five cases and noted the disappearance of fever, tachycardia, and joint pains in a few days.They, too, claimed that the P-R interval tended to revert to normal in the first week of treatment and that tachycardia was succeeded by brady- cardia, though the latter disappeared on reduction or withdrawal of cortisone.In one of their cases, after two weeks' treatment, there was a disappearance of physical signs upon which a diagnosis of myooarditis, pericarditis, pulmonary congestion, and pleural effusion had been made.Another interesting case was that described by Bell, Bell, and Wilson (1950) in which severe rheumatic pan- Examination on Admission (February 5, 1951).-Signsmitral and aortic disease unchanged.No evidence of failure.