Interferon-α for the Hypereosinophilic Syndrome
Authors: Robert M. Zielinski
Journal: Annals of Internal Medicine (1990)

Brief Reports1 November 1990Interferon-α for the Hypereosinophilic SyndromeRobert M. Zielinski, MD, William D. Lawrence, MDRobert M. Zielinski, MDSearch for more papers by this author, William D. Lawrence, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-9-716 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe hypereosinophilic syndrome is defined by unexplained eosinophilia (eosinophil count > 1.5 x 109/L) lasting more than 6 months (1). Characteristic clinical features include congestive heart failure with endocardial fibrosis (2), venous and arterial thromboembolism, neuropsychiatric dysfunction (3), anemia, and thrombocytopenia. These disease manifestations have been attributed to tissue infiltration by eosinophils and the direct toxic effects of the products of eosinophilic granules (1, 2, 4).Therapy has been directed at lowering the absolute eosinophil count to below 1 x 109/L with prednisone and the cytotoxic agent, hydroxyurea (1, 5). This therapeutic approach appears to have dramatically improved median survival...References1. Fauci A, Harley J, Roberts W, Ferrans V, Gralnick H, and Bjornson B. The idiopathic hypereosinophilic syndrome: clinical, pathophysiologic, and therapeutic considerations. Ann Intern Med. 1982;97:78-92. LinkGoogle Scholar2. Olsen E and Spry C. Relation between eosinophilia and endomyocardial disease. Prog Cardiovas Dis. 1985;27:241-54. CrossrefMedlineGoogle Scholar3. Moore P, Harley J, and Fauci A. Neurologic dysfunction in the idiopathic hypereosinophilic syndrome. Ann Intern Med. 1985;102:109-14. LinkGoogle Scholar4. Wassom D, Loegering D, and Solley G. Elevated serum levels of the eosinophil granule major basic protein in patients with eosinophilia. J Clin Invest. 1981;67:651-61. CrossrefMedlineGoogle Scholar5. Parillo F, Fauci A, and Wolff S. Therapy of the hypereosinophilic syndrome. Ann Intern Med. 1978;89:167-78. LinkGoogle Scholar6. Talpaz M, Kantarjian H, and McCredie K. Hematologic remission and cytogenetic improvement induced by recombinant interferon alpha in chronic myelogenous leukemia. N Engl J Med. 1986;314:1065-9. CrossrefMedlineGoogle Scholar7. Broxmeyer H, Lu L, Platzer E, Feit C, Juliano L, and Berish R. Comparative analysis of the influences of human gamma, alpha, and beta interferons on human multipotential (CFU-GEMM), erythroid (BFU-E) and granulocyte-macrophage (CFU-GM) progenitor cells. J Immunol. 1983;131:1300-5. CrossrefMedlineGoogle Scholar8. Saito H, Hayakawa T, Yui Y, and Shida T. Effect of human interferon on different functions of human neutrophils and eosinophils. Int Arch Allergy Appl Immunol. 1987;82:133-40. CrossrefMedlineGoogle Scholar9. Owen W, Rothenberg M, and Petersen J. Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome. J Exp Med. 1989;170:343-8. CrossrefMedlineGoogle Scholar10. Raghavachar A, Fleischer S, Frickhofen N, Heimpel H, and Fleischer B. T lymphocyte control of human eosinophilic granulopoiesis: clonal analysis in an idiopathic hypereosinophilic syndrome. J Immunol. 1987;139:3753-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Robert M. Zielinski, MD; William D. Lawrence, MDFrom the Veterans Affairs Medical Center and the State University of New York at Buffalo, Buffalo, New York. For current author addresses, see end of text. 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Busch, MD, H. Schmidt, MD, B. Steinke, MDRegulation and biological function of helminth-induced cytokine responses 1 November 1990Volume 113, Issue 9Page: 716-718KeywordsAnemiaCytotoxinsEosinophiliaEosinophilsFibrosisHeart failureVenous thromboembolism ePublished: 1 December 2008 Issue Published: 1 November 1990 PDF downloadLoading ...