tbuckley/cabot-search huggingface dataset:
(1) Immunopharmacological Characterization of Potent, Selective and Orally Available RORγt Inhibitors for Treatment of Autoimmune Diseases
Authors: Junya Masuda, Takashi Takeuchi, Chinatsu Tomizawa, Atsuko Kawaji, Toshimichi Asakura, Shunsuke Shimada, Takaaki Negishi, Yutaka Kato, Kazunari Nakao, Shoji Furusako
Journal: Journal of Allergy and Clinical Immunology (2015)
Gastroparesis following endoscopic submucosal dissection for early gastric cancer
Authors: J. Lian, S. Chen, Y. Zhang, L. Yao
Journal: Endoscopy (2011)

A 67-year-old man with no history of chronic disease was referred to our hospital because of progressive abdominal distention and poor appetite in September 2009. He had undergone endoscopic submucosal dissection (ESD) at our endoscopy center for a large, flat lesion in the gastric incisure 2 months previously. The lesion had been a type IIb with a diameter of 10 cm. It had been resected in one piece and was shown histologically to be an early gastric cancer with tumor-free lateral and vertical margins. Following his discharge, after 1 week the patient had begun to experience abdominal bloating and early fullness after only a few bites of food associated with reflux. The symptoms had deteriorated progressively over the subsequent 2 months, accompanied by weight loss of about 2.5 kg.
Computer Simulation Model of an X-ray Department
Authors: W. D. Jeans, S. R. Berger, R. Gill
Journal: BMJ (1972)

A computer simulation model has been designed to predict the effects of changes in the work load and resources of an <i>x</i>-ray department. The model has been used to produce histograms of patient waiting times and to show the effect on these of introducing changes in the speed of processing films and in the numbers of cubicles and radiographers available. The predicted benefit of using a faster film processor has been confirmed in practice.
Physical and Functional Interaction between hMSH5 and c-Abl
Authors: Wei Yi, Tai-Hsien Lee, Joshua D. Tompkins, Fengxue Zhu, Xiling Wu, Chengtao Her
Journal: Cancer Research (2006)

Despite being a member of the mismatch repair family of proteins, the biological functions of hMSH5 in human cells are presently elusive. Here, we report a novel physical and functional interaction between hMSH5 and c-Abl; the latter is a critical non-receptor tyrosine kinase involved in many critical cellular functions including DNA damage response, in which the kinase activity is normally suppressed in the absence of biological challenges. Our data indicate that hMSH5 associates with c-Abl in vivo, which is mediated by a direct physical interaction between the NH2 terminus (residues 1-109) of hMSH5 and the c-Abl SH3 domain. This physical interaction facilitates the activation of c-Abl tyrosine kinase and the phosphorylation of hMSH5 in response to ionizing radiation. Our data also indicate that the hMSH5 P29S variant overactivates the c-Abl tyrosine kinase activity. Furthermore, it seems that the tyrosine phosphorylation of hMSH5 promotes the dissociation of hMSH4-hMSH5 heterocomplex. Together, the revealed physical and functional interaction of hMSH5 with c-Abl implies that the interplay between hMSH5 and c-Abl could manipulate cellular responses to ionizing radiation-induced DNA damages.
Exorcising Ghosts and Unwelcome Guests
Authors: Stella S. Daskalopoulou, Dimitri P. Mikhailidis
Journal: Annals of Internal Medicine (2006)

Letters17 January 2006Exorcising Ghosts and Unwelcome GuestsStella S. Daskalopoulou, MD, MSc, DIC, PhD and Dimitri P. Mikhailidis, MD, MScStella S. Daskalopoulou, MD, MSc, DIC, PhDFrom Royal Free Hospital, London NW3 2QG, United Kingdom.Search for more papers by this author and Dimitri P. Mikhailidis, MD, MScFrom Royal Free Hospital, London NW3 2QG, United Kingdom.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-144-2-200601170-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We applaud the editors of Annals for their effort to increase awareness regarding ghostwriting (1). Drs. Laine and Mulrow cite our editorial (2), but a slight correction is needed; they imply that the GATE principles were proposed by the European Medical Writers Association. Actually, we initially proposed these guidelines ourselves in our editorial (2). However, we were influenced by the association's statements and by our own experience when we formulated these guidelines.There is increasing concern about ghostwriters because it is difficult to prove their existence. Therefore, whenever help from professional writers is necessary, it is imperative ...References1. Laine C, Mulrow CD. Exorcising ghosts and unwelcome guests [Editorial]. Ann Intern Med. 2005;143:611-2. [PMID: 16230729] LinkGoogle Scholar2. Daskalopoulou SS, Mikhailidis DP. The involvement of professional medical writers in medical publications [Editorial]. Curr Med Res Opin. 2005;21:307-10. [PMID: 15802002] CrossrefMedlineGoogle Scholar3. Place F. Ghost writing. Bull Med Libr Assoc. 1934;22:209-213. [PMID: 16016210] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Royal Free Hospital, London NW3 2QG, United Kingdom.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoExorcising Ghosts and Unwelcome Guests Christine Laine and Cynthia D. Mulrow Exorcising Ghosts and Unwelcome Guests Adam Jacobs Metrics Cited ByRe: Marchington JM, Burd GP. Author attitudes to professional medical writing support. Curr Med Res Opin 2014 Jul 9:1-6Fact or Fiction: The Need for Independent Pharmaceutical Policy Research 17 January 2006Volume 144, Issue 2Page: 149KeywordsConflicts of interest ePublished: 17 January 2006 Issue Published: 17 January 2006 CopyrightCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Endogenous Secretory Receptor for Advanced Glycation End Products in Non–Small Cell Lung Carcinoma
Authors: Seiichi Kobayashi, Hiroshi Kubo, Takashi Suzuki, Kota Ishizawa, Mitsuhiro Yamada, Mei He, Yasuhiko Yamamoto, Hiroshi Yamamoto, Hironobu Sasano, Hidetada Sasaki, Satoshi Suzuki
Journal: American Journal of Respiratory and Critical Care Medicine (2006)

The receptor for advanced glycation end products is a multiligand receptor that plays an important role in regulating the invasiveness and metastatic potential of cancer cells. A recently discovered novel splice variant, the endogenous secretory receptor for advanced glycation end products, mediates the receptor for advanced glycation end-product-associated cell responses by functioning as a decoy receptor.To evaluate the expression pattern of endogenous secretory receptor for advanced glycation end products in non-small cell lung carcinoma, and analyze its impact on prognosis.We performed immunohistochemical evaluation in 182 non-small cell lung carcinoma surgical specimens. The effect of an overexpressed receptor in cancer cell proliferation was also evaluated.The endogenous secretory receptor for advanced glycation end-product expression in cytoplasm was reduced or absent in 137 of the 182 (75%) carcinomas in contrast to normal lung tissues. mRNA expression was also suppressed in cancer cells. Overexpression of the secretory receptor in lung cancer cell lines had an inhibitory effect on cell proliferation, suggesting the reduced receptor expression accelerated tumor growth. Among patients with low expression of the cytoplasmic secretory receptor, the overall survival rate was significantly lower than that of patients with normal expression (p = 0.0003). This association was most prominent in TNM stage I patients (p = 0.0001). In a multivariate analysis, endogenous secretory receptor immunoreactivity was an independent prognostic factor with a relative risk of 3.1.The cytoplasmic endogenous secretory receptor for advanced glycation end-product expression has the potential to be a prognostic factor for predicting the outcome of curative surgery in patients with non-small cell lung carcinoma.
Albendazole--objective evidence of response in human hydatid disease
Authors: D. L. Morris
Journal: JAMA (1985)

Thirty-two patients with cysts caused by Echinococcus granulosus were treated with albendazole in a dosage of 10 mg/kg/day. Reversible abnormalities in liver-cell function tests were seen in five patients. Some radiological evidence of remission (on serial computed tomographic or ultrasound scanning) was seen in 15 of 22 patients undergoing a therapeutic course of albendazole (as opposed to those treated before or after surgery). In five patients, the cysts virtually disappeared. Apart from reduction in size, the appearance of a halo around the cysts and the apparent disappearance of daughter cysts has been seen. Serological findings have not correlated well with radiological or clinical improvement. Serum and cyst concentrations of albendazole sulfoxide (the principal metabolite) have been measured.
The Samaritan (Free) Hospital for Women and Children
Authors: A. Fausset
Journal: BMJ (1901)

The Building.Passers along that dullest of thoroughfares, the Marylebone Road, must know well the cheerful red- brick building which bears across its front the legend, " Samaritan Free Hospital for Women and Children."Situated on the south side of the road near the Paddington end, it is within convenient reach of Edgware Road and Baker Street Stations, and standing well back from the road and somewhat above its level, is as much protected from noise as a building in a London street may be.The brightness of its many-windowed front is not belied by the interior.Passing up the high flight of steps to the entrance, the visitor finds himself in a spacious hall, open to the roof, well venti- lated and lighted.In the basement are the kitchen offices, which are ample and convenient, linen-room, &c ; on the ground floor are the board-room, secretary's office, matron's sitting-room (a cheerful little apart- ment), nurses' dining-room, dispensary, and three wards ; on the first floor, several wards, matron's bed- room, operating theatre, &c.; the second floor contains seven wards and a room for two nurses ; and the third several single-bed wards, medical and surgical
Polycythemia Vera and Alkylating Agents
Authors: JOHN C. MORRISON
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 January 1982Polycythemia Vera and Alkylating AgentsJOHN C. MORRISON JR., M.D.JOHN C. MORRISON JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-1-123_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The UCLA conference on polycythemia (1) contains a serious misquotation. On p. 84 of the text is the statement: "As a result, the most recent recommendation of the Polycythemia Vera Study Group is that no alkylating agent should be used in this disorder." The reference for this statement is the article by Berk and associates reporting for the National Polycythemia Vera Study Group (2).Berk and associates said nothing of the kind, at least not in their paper. What they said was the following: "The Polycythemia Vera Study Group has discontinued the use of chlorambucil in the...References1. GOLDEHOCKINGKOEFFLERADAMSON DWHJ. Polycythemia: mechanisms and management. Ann Intern Med. 1981;95:71-87. LinkGoogle Scholar2. BERKGOLDBERGSILVERSTEIN PJM. Increased incidence of acute leukemia in polycythemia vera associated with chlorambucil therapy. N Engl J Med. 1981;304:441-7. CrossrefMedlineGoogle Scholar1. BERKGOLDBERGSILVERSTEIN PJM. Increased incidence of acute leukemia in polycythemia vera associated with chlorambucil therapy. N Eng J Med. 1981;304:441-7. CrossrefMedlineGoogle Scholar2. WEINFELDWESTINRIDELL AJB. Polycythemia vera terminating in acute leukemia: a clinical, cytogenetic and morphologic study in 8 patients treated with alkylating agents. Scand Haematol. 1977;19:255-72. CrossrefMedlineGoogle Scholar3. CASCIATOSCOTT DJ. Acute leukemia following prolonged cytotoxic agent therapy. Medicine. 1979;58:32-47. CrossrefMedlineGoogle Scholar4. REIMERHOOVERFRAUMENI RRJ. Acute leukemia after alkylating agent therapy of ovarian cancer. N Eng J Med. 1977;297:177-81. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHydroxyurea as Treatment for Sickle Cell Anemia 1 January 1982Volume 96, Issue 1Page: 123-124KeywordsPolycythemiaPolycythemia vera Issue Published: 1 January 1982 PDF DownloadLoading ...
An alternative pharmacological approach to the detection of anti-androgenic drugs for acne therapy
Authors: I. CLANACHAN, H. DEVITT, M.I. FOREMAN, W. PICTON
Journal: British Journal of Dermatology (1985)

Both testosterone and dihydrotestosterone may be able to stimulate sebaceous glands, and the glandular function may continue under direct testosterone control in the presence of 5 alpha-reductase blockade. Antagonism of sebaceous gland hypertrophy, induced by exogenous testosterone or dihydrotestosterone, has been studied in the hairless hamster using established and experimental drugs applied topically. The results support the proposition that testosterone plays a direct role in mediating sebaceous gland response. This suggests possibilities for the design of sebum inhibitory drugs with minimal systemic anti-androgenic side effects.
Scrambling, indirect passives, and wanna contraction
Authors: Yukio Otsu
Journal: Behavioral and Brain Sciences (2000)

Grodzinsky's general approach to the neuroscience of language is interesting, but the evidence currently available has problems with pragmatic infelicity in experiments involving Japanese scrambling and the interpretation of experimental results on Japanese indirect passives. I will suggest a more direct way of testing the Trace-Deletion Hypothesis (TDH).
Case 11-1970
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. McNeely, Denise J. Strieder, Stanley M. Wyman, Austin L. Vickery
Journal: New England Journal of Medicine (1970)

Presentation of CaseA fifty-seven-year-old woman was admitted to the hospital because of a cough and weakness.She had been well until several months previously, when there was the onset of a nonproductive cough associated with weakness, anorexia, night sweats and loss of 10 to 15 pounds in weight.The patient did not smoke or drink, and there was no history of previous pulmonary disease. There had been no hemoptysis or pain in the chest. She had not been exposed to tuberculosis. She had not traveled outside Massachusetts. One week before entry, on admission to another hospital, a mass in . . .
Late Status of Fontan Patients With Persistent Surgical Fenestration
Authors: Andrew M. Atz, Thomas G. Travison, Brian W. McCrindle, Lynn Mahony, Michael Quartermain, Richard V. Williams, Roger E. Breitbart, Minmin Lu, Elizabeth Radojewski, Renee Margossian, Wesley Covitz, Welton M. Gersony
Journal: Journal of the American College of Cardiology (2011)
Topical retapamulin ointment (1%, wt/wt) twice daily for 5 days versus oral cephalexin twice daily for 10 days in the treatment of secondarily infected dermatitis: Results of a randomized controlled trial
Authors: Lawrence Charles Parish, Joseph Lucius Jorizzo, John Jeffrey Breton, Joseph William Hirman, Nicole Elizabeth Scangarella, Ribhi Mohammad Shawar, Scott Matthew White
Journal: Journal of the American Academy of Dermatology (2006)
B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation
Authors: Frank Borriello, Michael P Sethna, Scott D Boyd, A.Nicola Schweitzer, Elizabeth A Tivol, Douglas Jacoby, Terry B Strom, Elizabeth M Simpson, Gordon J Freeman, Arlene H Sharpe
Journal: Immunity (1997)
Evolution and the Human Tail
Authors: Fred D. Ledley
Journal: New England Journal of Medicine (1982)

THE birth of a child with a caudal appendage resembling a tail generates an unusual amount of interest, excitement, and anxiety. There is something seemingly unhuman about the presence on a human infant of a "tail" like the tails found on other primates. It is incongruous; it violates our sense of anthropocentricity, and it raises issues that involve not only teratology and embryology but also our view of ourselves and our place in evolution.The human tail has long been an object of scientific curiosity.1 2 3 During the early part of the 19th century the caudal appendage was considered to be . . .
Why Collegiate Programs for Nurses?
Authors: Anne Kibrick
Journal: New England Journal of Medicine (1968)

THE subject of how nurses should be educated has been a matter of controversy for some time. It was brought into sharp focus by the recent position paper of the American Nurses' Association (ANA).1 This organization, taking cognizance of trends in this country, unequivocally stated in 1965 that the predominant existing programs for educating nurses were no longer adequate for preparing the professional nurse practitioner needed by today's society. The major points of the position paper were as follows: education for all who are licensed to practice nursing should take place in institutions of higher education; minimum preparation for beginning . . .
Advances in immunology. Volume 2.
Authors: Lester S. King
Journal: JAMA (1963)

This volume could serve as a model of composite authorship. Eight important topics are presented and are discussed by experts. The subjects include immunologic specificity and molecular structure, the heterogeneity of gamma-globulins, immunological significance of the thymus, cellular genetics of immune responses, antibody production by transferred cells, phagocytosis, antigen-antibody reactions in helminth infections, and embryological development of antigens. Each subject is treated analytically, not as a "survey of recent literature" or "review of current literature," but as a sound exposition which presents an excellent picture. The reviews presuppose a certain amount of knowledge in the area. They are not easy reading, and the elementary student who wants a bare introduction should try a more elementary volume. However, for those who have some acquaintance with the field and who wish to broaden their knowledge, as well as for those who are actively engaged in research and want authroitative analyses, the book
Insensitivity of Rapid Antigen Detection Methods and Single Blood Agar Plate Culture for Diagnosing Streptococcal Pharyngitis
Authors: Dennis L. Wegner
Journal: JAMA (1992)

To compare the sensitivity of five group A streptococcal antigen detection systems and single blood agar plate culture with a two-plate culture method for diagnosis of streptococcal pharyngitis.Two simultaneous throat swabs were obtained from consecutive patients with suspected streptococcal pharyngitis. One swab was tested for streptococcal antigen by physicians' office nurses and the other was cultured on both aerobic blood agar and anaerobic trimethoprim-sulfamethoxazole blood agar plates.Community office practice and community hospital laboratory.Consecutive outpatients seen by one of four pediatricians or a family practice physician.Results of rapid streptococcal antigen tests were compared with culture results either on a single aerobic blood agar plate or on the two-plate culture method.On throat swabs from 755 consecutive outpatients, the two-plate culture method detected 261 cases (defined as 100%) of group A streptococcal pharyngitis. The anaerobic trimethoprim-sulfamethoxazole plate alone, read at 1 and 2 days, detected 245 cases (94%). The blood agar plate used alone detected 189 cases (72%) at 2 days and 151 cases (58%) at 1 day. Antigen detection test results were positive for 106 throat specimens (41%), with individual kit sensitivity ranging from 31% to 50% compared with the two-plate culture method. Antigen detection test sensitivity decreased with decreasing colony counts. Antigen kit false-positivity rates varied from 0 to 28%.We conclude that the single blood agar plate culture and the antigen detection tests are insensitive, possibly leading the physician toward undertreatment and risking immunologic, local, or distant sequelae. The two-plate culture method should be the standard of practice to rule out streptococcal pharyngitis.
Cardiac Actions of Erythromycin
Authors: Milou-Daniel Drici, Björn C. Knollmann, Wen-Xiu Wang, Raymond L. Woosley
Journal: JAMA (1998)

Context.—Erythromycin is a widely used antibiotic that infrequently causes QT-prolongation and torsades de pointes cardiac arrhythmias. For antiarrhythmic drugs, women are at a higher risk for these cardiac arrhythmias, but few other classes of drugs have been studied.Objectives.—To determine whether female sex is a risk factor for cardiac arrhythmias associated with erythromycin, and if this can be correlated with in vitro measurements of the QT-response to erythromycin in male and female rabbit hearts.Design.—Food and Drug Administration (FDA) MEDWATCH database analysis and in vitro experiment.Main Outcome Measures.—Cardiac arrhythmia reports associated with erythromycin from 1970 until 1996 classified by patient sex and age, and effect of female sex on erythromycin-induced QT-prolongation in isolated perfused rabbit hearts.Results.—We observed a sex difference in cardiac arrhythmias associated with administration of erythromycin. A total of 346 cases were found in the FDA database: 201 females (58%), 110 males (32%), and 35 unspecified (10%). Forty-nine were life-threatening ventricular arrhythmias and deaths directly related to intravenous erythromycin lactobionate: 33 women (67%) and 16 men (33%) (P = .03). During the same period, no sex imbalance was present in the prescription pattern for intravenous erythromycin lacobionate (men 47%, women 49%, unspecified 4%). Perfusion with erythromycin caused significantly greater QT-prolongation in female rabbit hearts (mean [SD], 11.8% [2.3%]) than in male hearts (6.9% [2.1%]; P = .03).Conclusions.—As has been shown in reports of antiarrhythmic drugs, we found a female predominance in the FDA reports of erythromycin-associated cardiac arrhythmias. Based on in vitro experiments, a sex difference in cardiac repolarization response to erythromycin is a potential contributing factor.
Health of young and elderly informal carers: analysis of UK census data
Authors: T. Doran
Journal: BMJ (2003)

Concern has been mounting about the health and welfare of people who provide informal care for family or friends with chronic illness.In particular, young and elderly people-vulnerable groups in their own rightmay be carrying a heavy burden.The extent of the problem is not well known because estimates have been pieced together from ad hoc local studies and household sample surveys.These estimated that young carers in the United Kingdom numbered between 10 000 and 50 000, 1 and that about one in 20 older people in Great Britain spent long hours caring for sick family members. 2 In 2001, for the first time, the decennial UK census asked the entire population about caring responsibilities and general self rated health.We analysed the answers to these two new questions to explore carers' wellbeing.
TCT-337 Quantitative assessment of microcirculatory resistance in infarct-related and non-infarct-related coronary arteries in patients with ST-segment elevation myocardial infarction tretaed with primary percutaneous coronary intervention
Authors: Dejan Orlic, Branko Beleslin, Dejan Milasinovic, Milorad Zivkovic, Zlatko Mehmedbegovic, Vladimir Dedovic, Goran Stankovic
Journal: Journal of the American College of Cardiology (2014)