Haemophilus influenzae as a Cause of Adult Pneumonia
Authors: ELLIOT GOLDSTEIN
Journal: Annals of Internal Medicine (1967)

Article1 January 1967Haemophilus influenzae as a Cause of Adult PneumoniaELLIOT GOLDSTEIN, M.D., A. KATHLEEN DALY, B.S., CAROL SEAMANS, B.S.ELLIOT GOLDSTEIN, M.D.Search for more papers by this author, A. KATHLEEN DALY, B.S.Search for more papers by this author, CAROL SEAMANS, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-1-35 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe role of Haemophilus influenzae as a pulmonary pathogen in adults is not clear. The organism has only occasionally been reported to cause pneumonia (1-3), and in these cases pathogenicity has often been attributed to defects in host resistance (2, 3). The importance of H. influenzae in chronic pulmonary infections has not been definitively determined; for although the organism is frequently found in sputa of patients with chronic bronchitis and a majority of authors consider it a pathogen (4-6), some investigators still doubt its significance (7, 8).Much of this controversy can be ascribed to difficulties in obtaining bacteriologic data....References1. CROWELLLOUBE JSD: Primary hemophilus influenzae pneumonia; report of 4 cases. Arch. Intern. Med. (Chicago) 93: 921, 1954. CrossrefGoogle Scholar2. KEITHSCHREINER TAAW: Hemophilus influenzae in adult bronchopulmonary infection. Ann. Intern. Med. 56: 27, 1962. LinkGoogle Scholar3. KAPLANBRAUDE NMAI: Hemophilus influenzae infection in adults: observations on the immune disturbance. Arch. Intern. Med. (Chicago) 101: 515, 1958. CrossrefGoogle Scholar4. NORMAN PS: Antibiotics in chronic bronchitis and bronchiectasis. J. Chronic Dis. 15: 719, 1962. CrossrefMedlineGoogle Scholar5. NORMANHOOKPETERSDORFCLUFFGODFREYLEVY PSEWRGLEMPAH: Long-term tetracycline treatment of chronic bronchitis. JAMA 179: 833, 1962. CrossrefMedlineGoogle Scholar6. MORGANWOOD WKWH: Antibody response to haemophilus influenzae in obstructive airway disease. Lancet 1: 1128, 1965. CrossrefMedlineGoogle Scholar7. DAVISGROBOWKAMINSKITOMPSETTMCCLEMENT ALEJTRJH: Bacterial infection and some effects of chemoprophylaxis in chronic pulmonary emphysema. II. Chemoprophylaxis with daily chloramphenicol. Amer. Rev. Resp. Dis. 92: 900, 1965. MedlineGoogle Scholar8. DAVISGROBOWTOMPSETTMCCLEMENT ALEJRJH: Bacterial infection and some effects of chemoprophylaxis in chronic pulmonary emphysema. I. Chemoprophylaxis with intermittent tetracycline. Amer. J. Med. 31: 365, 1961. CrossrefMedlineGoogle Scholar9. ROBERTS A: Public Health Service activities in chronic respiratory diseases. Public Health Rep. 80: 336, 1965. CrossrefMedlineGoogle Scholar10. DOMZDICKSON CAAR: Agammaglobulinemias: relations and implications. Amer. J. Med. 23: 917, 1957. CrossrefMedlineGoogle Scholar11. SANFORDFAVOURTRIBEMAN JPCBMS: Absence of serum gamma globulins in an adult. New Eng. J. Med. 250: 1027, 1954. CrossrefMedlineGoogle Scholar12. WECHSLERWOLF HFMS: Agammaglobulinemia. Report of a case. JAMA 161: 526, 1956. CrossrefMedlineGoogle Scholar13. MERSELISSELLERSJOHNSONHOOK JGTFJEEW: Hemophilus influenzae meningitis in adults. Arch. Intern. Med. (Chicago) 110: 837, 1962. CrossrefMedlineGoogle Scholar14. LAURENZIPOTTERKASS GARTEH: Bacteriologic flora of the lower respiratory tract. New Eng. J. Med. 265: 1273, 1961. CrossrefMedlineGoogle Scholar15. LEESMCNAUGHT AWW: Bacteriology of lower-respiratory-tract secretions, sputum, and upper-respiratory-tract secretions in "normals" and chronic bronchitics. Lancet 2: 1112, 1959. CrossrefMedlineGoogle Scholar16. GREENKASS GMEH: The role of the alveolar macrophage in the clearance of bacteria from the lung. J. Exp. Med. 119: 167, 1964. CrossrefMedlineGoogle Scholar17. ORENFARNHAMSAITOMILOFSKYKARNOVSKY RAEKEML: Metabolic patterns in three types of phagocytizing cells. J. Cell Biol. 17: 487, 1963. CrossrefMedlineGoogle Scholar18. DANNENBERGWALTERKAPRAL AMPCFA: A histochemical study of phagocytic and enzymatic functions of rabbit mononuclear and polymorphonuclear exudate cells and alveolar macrophages. II. The effect of particle ingestion on enzyme activity; two phases of in vitro activation. J. Immun. 90: 448, 1963. Google Scholar19. GREENKASS GMEH: Factors influencing the clearance of bacteria by the lung. J. Clin. Invest. 43: 769, 1964. CrossrefMedlineGoogle Scholar20. GOLDSTEINGREEN EGM: The effect of acute renal failure on the bacterial clearance mechanisms of the lung. J. Lab. Clin. Med. In press, 1966. Google Scholar21. GOLDSTEINGREENSEAMANS EGMC: The effect of acidosis on pulmonary clearance of inhaled bacteria. Clin. Res. 14: 339, 1966. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, MassachusettsFrom the Channing Laboratory, Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, and Department of Bacteriology, Boston City Hospital; and the Departments of Medicine and of Bacteriology and Immunology, Harvard Medical School, Boston, Mass.This study was supported in part by grant HD01288 from the National Institute of Child Health and Human Development and grant AI-06577 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.Dr. Goldstein is a Public Health Service Post-doctoral Fellow.Requests for reprints should be addressed to Miss A. Kathleen Daly, Channing Laboratory, 784 Massachusetts Ave., Boston, Mass. 02118. 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