tbuckley/cabot-search huggingface dataset:
Food allergy to pumpkinseed ? characterization of allergens
Authors: R. Fritsch, H. Ebner, D. Kraft, C. Ebner
Journal: Allergy (1997)

In recent years, pumpkinseed has become increasingly popular as a foodstuff. Here we report the occurrence of allergic reactions (itching and swelling of oral mucosa, and asthma) to this member of the Cucurbitaceae family. We investigated three patients suffering from symptoms after ingestion of roasted pumpkinseed. All the patients fished for sport and used pressed pumpkinseed flour as bait. Sera were tested by the immunoblot technique for IgE reactivity with proteins of pumpkinseed extract. The immunoblot revealed pumpkinseed allergens of 13, 14, 36, 48, 77, and 87 kDa. Inhibition experiments with recombinant birch profilin were performed: IgE binding to the 14‐kDa allergen was completely blocked by preincubation of the sera with recombinant birch profilin. In conclusion, type I allergy to pumpkinseed is rare, and the patients' histories suggest inhalation of pumpkinseed flour during fishing to be the relevant route of sensitization, leading to food allergy to pumpkinseed.
Acute Oliguric Renal Failure Induced by Indomethacin: Possible Mechanism
Authors: J. JOSEPH WALSHE
Journal: Annals of Internal Medicine (1979)

A patient with compensated congestive heart failure suffered acute deterioration of her renal function and cardiac status, requiring peritoneal dialysis, in association with indomethacin therapy. Discontinuation of this inhibitor of prostaglandin synthesis led to a prompt improvement in both her renal function and cardiac status. The patient was rechallenged with indomethacin and again developed acute reduction of her glomerular filtration rate and severe volume retention, which were again totally reversed when the drug was stopped. Urinary prostaglandin E was measured by radioimmunoassay in this patient and five additional patients with congestive heart failure and prerenal azotemia. All patients were found to have elevated levels of urinary prostaglandin E. The possible role for renal prostaglandin E as a compensatory mechanism to the vasoconstrictive stimuli present in congestive heart failure is discussed. The potential danger of inhibitors of prostaglandin synthesis in patients with congestive heart failure and prerenal azotemia is emphasized.
Acute Myelogenous Leukemia
Authors: Laura C. Michaelis
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE INFLUENCE OF PROTEIN-FREE LIVER AND SPLEEN EXTRACTS ON THE BLOOD REGENERATION AND RESPIRATORY EXCHANGE OF ANEMIC RABBITS
Authors: A. Jeney
Journal: The Journal of Experimental Medicine (1927)

1. Respiratory exchange measurements may be used for gaining further evidence concerning the body changes during anemia, and are complementary to the hematological and histological data. 2. The heat production during anemia was slightly decreased. At the 3rd week it began to rise. 3. A protein-free liver extract has accelerated blood regeneration and at the same time increased the respiratory exchange of anemic animals. 4. A protein-free spleen extract has distinctly lowered the respiratory exchange of normal animals. The metabolism of anemic animals thus treated was practically the same as before bleeding and treatment. The recovery of the spleen extract-treated animals was not complete during the period of observation. This extract may have been somewhat toxic. In spite of this disturbing factor we are not inclined to accept the view of C. D. and E. W. Leake (15) and Thalhimer (16) that the spleen takes part in the stimulating effect upon blood regeneration when given in combination with red bone marrow by mouth.
Cigarette Smoking Prevalence Among Adults With HIV Compared With the General Adult Population in the United States
Authors: Rennatus Mdodo, Emma L. Frazier, Shanta R. Dube, Christine L. Mattson, Madeline Y. Sutton, John T. Brooks, Jacek Skarbinski
Journal: Annals of Internal Medicine (2015)

Background: The negative health effects of cigarette smoking and HIV infection are synergistic. Objective: To compare the prevalence of current cigarette smoking and smoking cessation between adults with HIV receiving medical care and adults in the general population. Design: Nationally representative cross-sectional surveys. Setting: United States. Patients: 4217 adults with HIV who participated in the Medical Monitoring Project and 27 731 U.S. adults who participated in the National Health Interview Survey in 2009. Measurements: The main exposure was cigarette smoking. The outcome measures were weighted prevalence of cigarette smoking and quit ratio (ratio of former smokers to the sum of former and current smokers). Results: Of the estimated 419 945 adults with HIV receiving medical care, 42.4% (95% CI, 39.7% to 45.1%) were current cigarette smokers, 20.3% (CI, 18.6% to 22.1%) were former smokers, and 37.3% (CI, 34.9% to 39.6%) had never smoked. Compared with the U.S. adult population, in which an estimated 20.6% of adults smoked cigarettes in 2009, adults with HIV were nearly twice as likely to smoke (adjusted prevalence difference, 17.0 percentage points [CI, 14.0 to 20.1 percentage points]) but were less likely to quit smoking (quit ratio, 32.4% vs. 51.7%). Among adults with HIV, factors independently associated with greater smoking prevalence were older age, non-Hispanic white or non-Hispanic black race, lower educational level, poverty, homelessness, incarceration, substance use, binge alcohol use, depression, and not achieving a suppressed HIV viral load. Limitation: Cross-sectional design with some generalizability limitations. Conclusion: Adults with HIV were more likely to smoke and less likely to quit smoking than the general adult population. Tobacco screening and cessation strategies are important considerations as part of routine HIV care. Primary Funding Source: Centers for Disease Control and Prevention.
STUDIES OF THE ACTIVITY OF DIPHTHERIA TOXIN
Authors: J. L. Duncan, N. B. Groman
Journal: The Journal of Experimental Medicine (1967)

It has been demonstrated that a saturating dose of diphtheria toxin produced a 90% inhibition of polio-virus replication in HeLa cells. This inhibition was reflected in infectious viral RNA synthesis and in mature virus production. Toxin had no direct effect on virus particles or I-RNA, and poliovirus adsorption and eclipse appeared to be carried out normally in intoxicated cells. When toxin was given at various time intervals after infection, the amount of inhibition depended on the time of toxin addition. Toxin given before or immediately after infection gave maximum inhibition, while toxin given several hours after infection had little effect. The data suggest that toxin inhibits viral replication through its effect on protein synthesis. It is likely that a critical step in the viral replication cycle, the production of poliovirus-induced RNA polymerase, is inhibited, and possibly the synthesis of capsid protein. Ammonium salts and the aliphatic amines, glycamine and prolamine, prevented the inhibition of viral replication by toxin. The kinetics of the protective action of ammonium chloride and diphtheria antitoxin are remarkably similar.
Validating the SF-36: Authors' reply
Authors: J. Brazier, R. Harper, N. Jones, K. Thomas, L. Westlake, T. Usherwood
Journal: BMJ (1992)

repeatability of only one scale point on a range 0-100, which seems unlikely for a score derived from responses to questions concerning subjective symptoms.They say they have used the method of Bland and Altman,2 but the results given-the mean difference and the distribution of the differ- ences-are not good measures of reliability.Moreover, Bland and Altman proposed that the limits of agreement should be used to assess repeatability.For example, twice the standard deviation of the differences gives a range within which 95% of the differences will lie.A mean difference of zero implies that there is no consistent trend affecting test and retest results (all the patients getting better, for example).It does not imply that the measure is reliable.The table
Abstract 1828: Predictive Value of T wave Morphology in LQT2 Patients with Borderline QTc Duration
Authors: Wojciech Zareba, Greg Pietrasik, Arthur J Moss, Scott McNitt
Journal: Circulation (2007)

Background : Long QT syndrome patients with type 2 disorder (LQT2) show QTc prolongation and changes in T wave morphology consisting of flat, low-amplitude and notched T waves. This study aimed to evaluate the prognostic significance of T wave morphology in LQT2 patients for predicting cardiac events.   Methods:  Study population consisted of 405 genetically confirmed carriers of LQT2 gene mutations with QTc ≥440 ms (mean age: 26 years). Baseline ECGs were used to evaluate QTc duration and T wave morphology using classification adopted by the study and differentiating T waves as normal or abnormal (flat, broad upsloping, notched). The association between T wave morphology and endpoints, defined as aborted cardiac arrest or death, was tested separately in patients with borderline QTc (440–500ms) and in patients with definitely prolonged QTc (>500ms).   Results:  Abnormal T wave morphology was observed in 37% of 281 patients with borderline QTc (440–500 ms) and in 50% of 124 patients with definitely prolonged QTc (>500 ms). Cox regression analysis revealed that, in LQT2 patients with borderline QTc, presence of T wave abnormalities was associated with significantly increased risk of aborted cardiac arrest or death (HR=4.10; p=0.005). The analysis of 124 patients with QTc>500 showed no significant association between T wave abnormalities and cardiac events (HR=0.69; p=0.446).   Conclusions:  T wave abnormalities consisting of flat, broad based, or notched T waves indicate an increased risk of aborted cardiac arrest or death in LQT2 patients with borderline QTc. In LQT2 patients with definitely prolonged QTc, T wave abnormality does not improve risk stratification.
Impact resistance of drinking glasses: Authors' reply
Authors: J P Shepherd, G Kidner, R Huggett
Journal: BMJ (1992)

fragments on breaking in the manner described, glasses annually attests to the limited life of most covered that the manufacturers had made a Certainly the base, the thickest part, does fragment pub glasses.commercial decision to stop marketing diazoxide when a glass breaks, but this is not so with the thin Tempering will never completely eliminate tablets.When we asked how such a decision could si'de wall, which either remains intact or breaks inj'uries due to glass, but it substantially reduces be made without consultation we were informed into pieces with "razor blade" edges.the risk of breakage.As De Grave states in the that consultation, with endocrinologists had taken Interestingly, the French claim only that their conclusion of a paper cited by Grimes, "In fact, place.We have not yet been able to locate those glass is three times stronger than a normal, stress toughening has provided an opportunity for the consulted.free glass; we dispute this figure, let alone Shepherd production of high resistance tumblers, dishes,We invite other would be users of the drug and colleagues' claim that it is six times stronger.plates, bowls, casseroles, etc, of great variety of to write to the suppliers, Allen and Hanburys Breaking a used tempered glass does not present a shapes, and colours which are now normally used Limited, Stockley Park West, Uxbridge, Middle- problem to an assailant, and the same jagged by everyone."' sex UB 11 IBT, requesting that the drug once more shards characteristic of normal glassware on J P SHEPHERD be supplied as tablets.breakage are produced.
Intravenous immunoglobulins control scleromyxoedema
Authors: A Righi
Journal: Annals of the Rheumatic Diseases (2002)

Background: Scleromyxoedema is a variant of papular mucinosis affecting the skin and internal organs. The different therapeutic approaches proposed for scleromyxoedema are still unsatisfactory. Intravenous immunoglobulin (IVIg) has been successfully employed in the treatment of connective tissue diseases and vasculitides. Patients: The successful treatment of three cases of scleromyxoedema with IVIg is reported here. Conclusions: The relatively low risk of the drug and the high effectiveness seen in three patients suggest that IVIg is a new treatment potentially useful in scleromyxoedema.
Are we going OTT about ITT?
Authors: J.R. Rees
Journal: British Journal of Dermatology (2002)

Sir, The recent editorial by Hywel Williams1 on intention‐to‐treat analysis (ITT) brings to mind the remarks made by the distinguished American epidemiologist and biostatistician, Alvan Feinstein, when referring to the folly of ITT: in an attempt to exclude bias we have excluded common sense.2, 3 Hywel Williams favours the conventional wisdom, at least amongst epidemiologists and some biostatisticians, that a clinical trial by way of some form of naive inductionism tells one how to treat patients. I disagree, and suggest it is better to think of a clinical trial as a natural experiment that allows one to test a hypothesis, a hypothesis that then informs clinical practice. Imagine an experiment in a genetics laboratory. You wish to see whether a certain species of messenger RNA is expressed in a sample of RNA from a particular tissue. You add various enzymes, some oligonucleotide primers, some substrate and the target RNA. The mixture is then incubated at an appropriate temperature. If all goes according to plan, when you run an aliquot of the finished reaction out on a gel you will see whether a band is present. Imagine however, that while you are out of the laboratory, somebody comes in and changes the temperature of your incubator. The result is that the enzyme is unable to work appropriately and the specificity of your primers is changed. In either case the results are erroneous. Now, of course, you can argue that organisms live at various different temperatures, that global warming may be occurring, that many people spend lots of time in sweaty and hot nightclubs and so on… Most biologists, however, just chuck the results out and do the experiment properly. Not the ITT trialist however.
Prophylaxis of pulmonary embolism.
Authors: A M Gardner, R L Midgley, M J Turner, C C Wilmshurst
Journal: BMJ (1970)

BRITISHwas detected.Further aspirations produced no benefit, but an increased dose of steroids helped.However, two weeks later she developed severe respiratory failure and died.At necropsy the lungs showed prominent arterial radicles, a moderate amount of oedema, and scattered, mainly subpleural, areas suggestive of chronic pneumonitis.Both latter features were worse on the left (weight 985g.)than on the right (weight 720g.)Both pleural spaces contained old fibrous adhesions and bilateral yellow effusions.The heart (weight 360g.)showed right ventricular hypertrophy (10mmn.)and dilatation; the right auricle was normal.There was no thrombosis in the syst-mic vessels.
Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population
Authors: Tomomitsu Hirota, Michishige Harada, Masafumi Sakashita, Satoru Doi, Akihiko Miyatake, Kimie Fujita, Tadao Enomoto, Motohiro Ebisawa, Shigemi Yoshihara, Emiko Noguchi, Hirohisa Saito, Yusuke Nakamura, Mayumi Tamari
Journal: Journal of Allergy and Clinical Immunology (2007)
Exposure to a farming environment has allergen-specific protective effects on TH2-dependent isotype switching in response to common inhalants
Authors: Debra A. Stern, Josef Riedler, Dennis Nowak, Charlotte Braun-Fahrlander, Ines Swoboda, Nadja Balic, Kuan-Wei Chen, Susanne Vrtala, Hans Grönlund, Marianne van Hage, Rudolf Valenta, Susanne Spitzauer, Erika Von Mutius, Donata Vercelli
Journal: Journal of Allergy and Clinical Immunology (2006)
Clinical trial of common treatments for low back pain in family practice.
Authors: J R Gilbert, D W Taylor, A Hildebrand, C Evans
Journal: BMJ (1985)

The results of a multicentered randomised clinical trial are reported of bed rest and of a physiotherapy and education programme for patients who presented in family practice with an acute episode of low back pain. No beneficial effect of either treatment was observed on several clinical outcome measures, including straight leg raising, lumbar flexion, activities of daily living, and pain. In fact the results favoured early mobilisation over bed rest and suggested that the physiotherapy and education programme was doing more harm than good. Moreover, additional analyses, which focused on clinically interesting patient subgroups, discovered no subset of patients who benefited from either of the treatments under study. Having failed to identify any clinically important benefits, or other explanations for these negative results, we can only conclude that family doctors have little reason to prescribe either bed rest or isometric exercises to patients who suffer from low back pain.
PYELONEPHRITIS COMPLICATING PREGNANCY AFTER NEPHRECTOMY
Authors: John E. Hall
Journal: JAMA (1925)

I report the management of a case of pyelonephritis occurring in a woman who became pregnant about one year after I had performed a nephrectomy on her for pyonephrosis of the left kidney. The right kidney was at all times free of infection during her illness from the left-sided pyonephrosis. Attention is called to this fact, so that it may not be supposed that the pyelonephritis developing during pregnancy was due to impairment of the right kidney from infection at the time of this pyonephrosis. The primary focus of infection responsible for the pyelonephritis could not be ascertained. The patient's tonsils were removed shortly after her nephrectomy, and her teeth and accessory sinuses were in perfect condition. <h3>REPORT OF CASE</h3> Mrs. G. J., aged 27, became pregnant in May, 1924, and came to me the latter part of June for advice as to precautions necessary for her to take during
Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways
Authors: Charles N. Serhan, Ernst Oliw
Journal: Journal of Clinical Investigation (2001)

Unorthodox routes (I): novel routes for prostanoid biogenesis in seminal fluidPGs were initially discovered in human seminal fluid and originate from the seminal vesicles.Semen contains PGs derived from the three fatty acids, dihomogammalinoleic, arachidonic, and eicosapentaenoic acids.The two most abundant PGs are 19R-hydroxy-PGE 1 and 19R-hydroxy-1482
A case of generalized hair follicle hamartoma associated with diffuse sclerosis of the face
Authors: H. Shimizu, T. Takai, M. Ichihashi, M. Ueda
Journal: British Journal of Dermatology (2000)

Journal Article A case of generalized hair follicle hamartoma associated with diffuse sclerosis of the face Get access H. Shimizu, H. Shimizu Department of Dermatology, Kobe University School of Medicine, 7‐5‐1 Kusunoki‐cho, Chuo‐ku, Kobe 650–0017, JapanE‐mail: mueda@med.kobe‐u.ac.jp Correspondence: Masato Ueda. Search for other works by this author on: Oxford Academic Google Scholar T. Takai, T. Takai Department of Dermatology, Kobe University School of Medicine, 7‐5‐1 Kusunoki‐cho, Chuo‐ku, Kobe 650–0017, JapanE‐mail: mueda@med.kobe‐u.ac.jp Correspondence: Masato Ueda. Search for other works by this author on: Oxford Academic Google Scholar M. Ichihashi, M. Ichihashi Department of Dermatology, Kobe University School of Medicine, 7‐5‐1 Kusunoki‐cho, Chuo‐ku, Kobe 650–0017, JapanE‐mail: mueda@med.kobe‐u.ac.jp Correspondence: Masato Ueda. Search for other works by this author on: Oxford Academic Google Scholar M. Ueda M. Ueda Department of Dermatology, Kobe University School of Medicine, 7‐5‐1 Kusunoki‐cho, Chuo‐ku, Kobe 650–0017, JapanE‐mail: mueda@med.kobe‐u.ac.jp Correspondence: Masato Ueda. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 5, 1 November 2000, Pages 1103–1105, https://doi.org/10.1046/j.1365-2133.2000.03864.x Published: 01 November 2000
Indian government pledges new resources to improve child survival
Authors: G. Mudur
Journal: BMJ (2013)

India’s health ministry has announced plans to improve the health of adolescents and also to evaluate progress of states and districts on child survival under a fresh package of initiatives to reduce mortality among children under 5 years old.

The announcement, made at a summit on child survival held on 7 to 9 February in the town of Mahabalipuram, Tamil Nadu, has been hailed by international, non-governmental, and donor agencies.

But some paediatricians and public health experts have warned that future gains in child survival are likely to hinge on how India resolves certain lingering, contentious problems such as neonatal deaths and severe acute malnutrition.

At the summit the health ministry released documents that it said described “operational guidelines” to integrate adolescent health services with reproductive, maternal, newborn, and child health activities. The ministry …
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
Authors: Gregg L. Semenza
Journal: Journal of Clinical Investigation (2013)

Hypoxia occurs frequently in human cancers and induces adaptive changes in cell metabolism that include a switch from oxidative phosphorylation to glycolysis, increased glycogen synthesis, and a switch from glucose to glutamine as the major substrate for fatty acid synthesis. This broad metabolic reprogramming is coordinated at the transcriptional level by HIF-1, which functions as a master regulator to balance oxygen supply and demand. HIF-1 is also activated in cancer cells by tumor suppressor (e.g., VHL) loss of function and oncogene gain of function (leading to PI3K/AKT/mTOR activity) and mediates metabolic alterations that drive cancer progression and resistance to therapy. Inhibitors of HIF-1 or metabolic enzymes may impair the metabolic flexibility of cancer cells and make them more sensitive to anticancer drugs.
From semantic analogy to theoretical confusion?
Authors: Valérie Gaveau, Michel Desmurget, Pierre Baraduc
Journal: Behavioral and Brain Sciences (2004)

We briefly address three issues that might be important to evaluate the validity of the “emulation theory”: (1) Does it really say something new? (2) Are similar processes engaged in action, imagery, and perception? (3) Does a brain amodal emulator exist?