Acute Pancreatitis Due to 5-Aminosalicylate
Authors: Bashir Sachedina
Journal: Annals of Internal Medicine (1989)

Brief Reports15 March 1989Acute Pancreatitis Due to 5-AminosalicylateBashir Sachedina, MD, Fred Saibil, MD, Lawrence B. Cohen, MD, Janet Whittey, BSCPhmBashir Sachedina, MDSearch for more papers by this author, Fred Saibil, MDSearch for more papers by this author, Lawrence B. Cohen, MDSearch for more papers by this author, Janet Whittey, BSCPhmSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-6-490 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcute pancreatitis has been described as a complication of sulfasalazine therapy in patients with inflammatory bowel disease (1-3). In a critical review, Mallory and Kern (4) suggested that the sulfonamide component of sulfasalazine was responsible for this adverse effect because of the structural similarity of the sulfonamides to the thiazide diuretics, which are a well recognized cause of drug-induced pancreatitis. Sulfasalazine comprises sulfapyridine linked by an azo bond to 5-aminosalicylate (5-ASA), which is the active ingredient.We report a case of 5-aminosalicylate-induced pancreatitis (Asacol, Norwich Eaton Pharmaceuticals Inc., Cambridge, Ontario, Canada). This complication has not previously been published with the...References1. BlockGenantKirsner MHJ. Pancreatitis as an adverse reaction to salicylazosulfapyridine. N Engl J Med. 1970;282:380-2. CrossrefMedlineGoogle Scholar2. SuryapranataDeVries HH. Pancreatitis associated with Sulphasalazine. Br Med J. 1986;292:732. MedlineGoogle Scholar3. DasEastwoodMcManusSircus KMJW. Adverse reactions during salicylazosulfapyridine therapy and the relation with drug metabolism and acetylator phenotype. N Engl J Med. 1973;289:491-5. CrossrefMedlineGoogle Scholar4. MalloryKern AF. Drug induced pancreatitis: Critical review. Gastroenterology. 1980;78:813-20. CrossrefMedlineGoogle Scholar5. Poldermansvan Blankenstein DM. Pancreatitis induced by disodium azodisalicylate. Am J Gastroenterol. 1988;83:578-80. MedlineGoogle Scholar6. SeidmanDeckelbaumOwen ERH. Relapsing pancreatitis in association with Crohn's disease. J Pediatr Gastroenterol Nutr. 1983;2:178-82. CrossrefMedlineGoogle Scholar7. SeyrigJianModigliani JRR. Idiopathic pancreatitis associated with inflammatory bowel disease. Dig Dis Sci. 1985;30:1121-6. CrossrefMedlineGoogle Scholar8. LeggeHoffmanCarlson DHH. Pancreatitis as a complication of regional enteritis of the duodenum. Gastroenterology. 1971;61:834-7. CrossrefMedlineGoogle Scholar9. AltmanPhillipsBanksKlotz HSSH. Pancreatitis associated with duodenal Crohn's disease. Am J Gastroenterol. 1983;78:174-7. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From Sunnybrook Medical Centre, University of Toronto, Toronto, Ontario, Canada. For current author addresses, see end of text. 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Peppercorn, MDGastrointestinal drugsPANCREATITIS INDUCED BY 5-AMINOSALICYLIC ACID 15 March 1989Volume 110, Issue 6Page: 490-492KeywordsAcute pancreatitisDiureticsDrugsInflammatory bowel diseasePancreatitisSulfonamide Issue Published: 15 March 1989 PDF downloadLoading ...