tbuckley/cabot-search huggingface dataset:
Docetaxel-loaded thermoresponsive conjugated linoleic acid-incorporated poloxamer hydrogel for the suppression of peritoneal metastasis of gastric cancer
Authors: Woo Kyun Bae, Myong Suk Park, Ji Hee Lee, Jun Eul Hwang, Hyun Jeong Shim, Sang Hee Cho, Dae-Eun Kim, Hyang Mi Ko, Chong-Su Cho, In-Kyu Park, Ik-Joo Chung
Journal: Biomaterials (2012)
The Bronchiectasis Severity Index. An International Derivation and Validation Study
Authors: James D. Chalmers, Pieter Goeminne, Stefano Aliberti, Melissa J. McDonnell, Sara Lonni, John Davidson, Lucy Poppelwell, Waleed Salih, Alberto Pesci, Lieven J. Dupont, Thomas C. Fardon, Anthony De Soyza, Adam T. Hill
Journal: American Journal of Respiratory and Critical Care Medicine (2014)

There are no risk stratification tools for morbidity and mortality in bronchiectasis. Identifying patients at risk of exacerbations, hospital admissions, and mortality is vital for future research.
The Medical Library
Authors: James W. Lansing
Journal: JAMA (1975)

<h3>To the Editor.—</h3> As one trained in the field of administration who now finds himself working in a community hospital medical library, I read with interest Dr. King's analysis of a medical library in the university environment (231:833, 1975). Many of his comments are equally applicable to the medical library in a hospital setting. I do question one of his observations, namely that a library cannot be all things to all men. Here at Roanoke Memorial Hospitals Library we serve a varied range of interests and specialities. With seven separate training schools, 30 residents in four different programs, departments that range alphabetically from Administration to Volunteer Services, and very active users in the house and attending staffs, we<i>do</i>try to be all things to all men (and women, too). Although some departments and schools maintain individual book collections for ready reference, we feel that a centralized library, performing a
The Relation of a Scarlet Fever Epidemic to the Milk Supply.
Authors: Henry B. Hemenway
Journal: JAMA (1907)

Evanston, Ill., Feb. 17, 1907. <h3>To the Editor:</h3> —As a matter of information you may be interested in knowing why the Evanston Branch of the Chicago Medical Society<i>unanimously</i>passed a resolution stating that in the opinion of its members almost the sole source of contagion in the recent epidemic of scarlet fever was infected milk. Last August there were several cases of scarlet fever which we were satisfied came from infection in the milk supply of a certain company which obtained its milk from a point in a neighboring state. For a short time this company gave milk from another source, and furnished affidavits and statements to show that we were mistaken. Occasional cases occurred until Jan. 13, 1907. At that time this company was supplying less than one-seventh of the milk for Evanston, and from its Evanston depot. It also supplied from this depot Wilmette, Kenilworth, Rogers Park
Local Delivery of Gene Vectors From Bare-Metal Stents by Use of a Biodegradable Synthetic Complex Inhibits In-Stent Restenosis in Rat Carotid Arteries
Authors: Ilia Fishbein, Ivan Alferiev, Marina Bakay, Stanley J. Stachelek, Peter Sobolewski, Meizan Lai, Hoon Choi, I. -W. Chen, Robert J. Levy
Journal: Circulation (2008)

Background— Local drug delivery from polymer-coated stents has demonstrated efficacy for preventing in-stent restenosis; however, both the inflammatory effects of polymer coatings and concerns about late outcomes of drug-eluting stent use indicate the need to investigate innovative approaches, such as combining localized gene therapy with stent angioplasty. Thus, we investigated the hypothesis that adenoviral vectors (Ad) could be delivered from the bare-metal surfaces of stents with a synthetic complex for reversible vector binding. Methods and Results— We synthesized the 3 components of a gene vector binding complex: (1) A polyallylamine bisphosphonate with latent thiol groups (PABT), (2) a polyethyleneimine (PEI) with pyridyldithio groups for amplification of attachment sites [PEI(PDT)], and (3) a bifunctional (amine- and thiol-reactive) cross-linker with a labile ester bond (HL). HL-modified Ad attached to PABT/PEI(PDT)-treated steel surfaces demonstrated both sustained release in vitro over 30 days and localized green fluorescent protein expression in rat arterial smooth muscle cell cultures, which were not sensitive to either inhibition by neutralizing anti-Ad antibodies or inactivation after storage at 37°C. In rat carotid studies, deployment of steel stents configured with PABT/PEI(PDT)/HL-tethered adenoviral vectors demonstrated both site-specific arterial Ad GFP expression and adenovirus-luciferase transgene activity per optical imaging. Rat carotid stent delivery of adenovirus encoding inducible nitric oxide synthase resulted in significant inhibition of restenosis. Conclusions— Reversible immobilization of adenovirus vectors on the bare-metal surfaces of endovascular stents via a synthetic complex represents an efficient, tunable method for sustained release of gene vectors to the vasculature.
Poison and the Pathologist
Authors: Lester Adelson
Journal: JAMA (1964)

The pathologist participating in the investigation of a known or alleged poisoning fatality has a multifaceted responsibility. He must search for and recognize anatomic changes produced by the toxic substance, while recalling that many poisons produce no organic injury even when they are present in lethal concentration. He should always preserve sufficient quantities of body fluids, excreta, and viscera in properly labelled containers so that the chemical analyst has adequate material for all possibilities. Frequent consultation with the toxicologist is essential in the interest of expediting the search for the lethal chemical. Ultimately it falls upon the pathologist to establish the cause of death in the light of all the anatomic and chemical findings.
Cardiac Positron-Emission Tomography Images With an Amyloid-Specific Tracer in Familial Transthyretin-Related Systemic Amyloidosis
Authors: Katsutoshi Furukawa, Shu-ichi Ikeda, Nobuyuki Okamura, Manabu Tashiro, Naoki Tomita, Shozo Furumoto, Ren Iwata, Kazuhiko Yanai, Yukitsuka Kudo, Hiroyuki Arai
Journal: Circulation (2012)
JUNG'S PSYCHOTHERAPY
Authors: E. A. Bennet
Journal: BMJ (1955)

<h3>Abstract</h3> Severe SARS-CoV-2 infection is linked to the presence of autoantibodies against multiple targets, including phospholipids and type-I interferons. We recently identified activation of an autoimmune-prone B cell response pathway as correlate of severe COVID-19, raising the possibility of <i>de novo</i> autoreactive antibody production during the antiviral response. Here, we identify autoreactive antibodies as a common feature of severe COVID-19, identifying biomarkers of tolerance breaks that may indicate subsets of patients that may particularly benefit from immunomodulation.
Cardiac Disease: A Logical Approach Considering DRGs
Authors: Jerzy Gajewski
Journal: JAMA (1987)

Cost-containment issues are among the hottest topics in medical circles these days. Simply including the abbreviation "DRG" (diagnosis related groups) catches the eye and generates instant interest and, hopefully, sales. Two of my associates, when glancing at the cover of this book, had the same reflex reaction: "a quick reference on how to beat the system"! Fortunately, nothing could be further from the truth, for this is not a "How to..." manual. Actually, this publication represents probably the shortest, most concise textbook on cardiac diseases written, with particular emphasis on appropriateness and honesty. The authors realized very well that, despite wide criticism, the era of DRGs as a form of cost control is upon us and that it would be beneficial to the cardiologist to understand the major rules of the system and learn how to cooperate with it. The authors, both highly experienced clinicians, discuss basic diagnostic and therapeutic
Escape Fire: Designs for the Future of Health Care
Authors: David Woods
Journal: BMJ (2004)

Donald M Berwick Jossey Bass, $30, pp 352 ISBN 0 7879 7217 7 Also available as an e-book www.josseybass.com Rating:![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> This is a collection of 11 speeches that Dr Donald Berwick, cofounder and president of the US Institute for Healthcare Improvement, delivered to the annual meetings of the National Forum on Quality Improvement in Health Care between 1992 and 2002. Berwick is modest about his institute and his work, asking in the preface to this anthology, “With so much different, why do these speeches strike me as so repetitive? Metaphor after metaphor, list after list, story … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Pulmonary mechanics and diffusion after 'shock lung'.
Authors: J C Yernault, M Englert, R Sergysels, A De Coster
Journal: Thorax (1975)

Pulmonary function studies performed in seven patients who had recovered from 9shock lung9 showed a highly significant decrease of diffusing properties of the lung, a slight loss of lung recoil pressure, and a borderline increase of residual volume with normal vital capacity and total lung capacity. Pulmonary compliance was normal. The interpretation of these findings is discussed.
Vascular Lesions Associated with Use of Oral Contraceptives.
Authors: Ancel Blaustein
Journal: Annals of Internal Medicine (1971)

Meeting Abstracts1 May 1971Vascular Lesions Associated with Use of Oral Contraceptives.Ancel Blaustein, M.D., F.A.C.P., Lewis Shenker, M.D.Ancel Blaustein, M.D., F.A.C.P.Search for more papers by this author, Lewis Shenker, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-817_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA blind retrospective study of surgical specimens from extragenital sites was made in order to determine if any vascular lesions could be associated with the use of oral contraceptive agents. Two hundred and ninety specimens were examined. The age group was 18 to 39 years. Tissues studied were breast, thyroid gland, gall bladder, peripheral blood vessels, nasal and vocal cord polyps, lymph nodes, and appendix. One hundred and fortysix surgical specimens were from patients who had never used oral contraceptives, and 141 were from patients who either were taking oral contraceptives at the time of surgery or had taken them... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Ancel Blaustein, M.D., F.A.C.P.; Lewis Shenker, M.D.Affiliations: Queens, N.Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1971Volume 74, Issue 5Page: 817-817KeywordsAge groupsBladderBlood vesselsLesionsLymph nodesOral contraceptive therapyRetrospective studiesSurgeryThyroid ePublished: 1 December 2008 Issue Published: 1 May 1971 PDF downloadLoading ...
CYP2E1 Genetic Polymorphisms and Risk of Nasopharyngeal Carcinoma in Taiwan
Authors: Allan Hildesheim, Lucy M. Anderson, Chien-Jen Chen, Yu-Juen Cheng, Louise A. Brinton, Ann K. Daly, C. D. Reed, I-How Chen, Neil E. Caporaso, Mow-Ming Hsu, Jen-Yang Chen, Jeffrey R. Idle, Robert N. Hoover, Czau-Siung Yang, Saranjit K. Chhabra
Journal: JNCI Journal of the National Cancer Institute (1997)

Background: Nasopharyngeal carcinoma occurs disproportionately among individuals of Chinese descent. The cytochrome P450 2E1 enzyme (CYP2E1) is known to activate nitrosamines and other carcinogens that are possibly involved in the development of this disease. Certain alleles of the CYP2E1 gene are thought to be more highly expressed than others, and their distribution varies between Asian and Caucasian populations. We conducted a case-control study to investigate whether such variations affect the risk of developing nasopharyngeal cancer. Methods: Three hundred sixty-four patients with nasopharyngeal carcinoma (96% of 378 eligible patients) and 320 control subjects (86% of 374 eligible subjects) were studied. A risk factor questionnaire was administered to participants to assess factors postulated to be linked to nasopharyngeal carcinoma. Peripheral blood was obtained from all subjects and DNA was purified from nucleated cells. A polymerase chain reaction-based restriction fragment length polymorphism assay that used the restriction enzymes Rsa I and Dra I was used to detect wild-type and variant forms of the CYP2E1 gene. Results: Individuals homozygous for an allele of the CYP2E1 gene that is detected by Rsa I digestion (c2 allele) were found to have an increased risk of nasopharyngeal carcinoma (relative risk [RR] = 2.6; 95% confidence interval [CI] = 1.2–5.7); this effect was limited to nonsmokers (RR = 9.3; 95% CI = 2.7–32) and was not affected by alcohol consumption. Conclusions: Our findings suggest that the CYP2E1 genotype is a determinant of nasopharyngeal carcinoma risk.
Vibrio fetus Infection
Authors: MICHAEL SANDS
Journal: Annals of Internal Medicine (1975)

Comments1 January 1975Vibrio fetus InfectionMICHAEL SANDS, M.D.MICHAEL SANDS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-1-124_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I read with great interest the case report by Fearrington and associates, "Non-Cholera Vibrio Septicemia and Meningoencephalitis," (Ann Intern Med 81: 401, 1974) and was disturbed by what appears both an inadequate identification of the organism and inadequate review of the pertinent literature.I have no doubt the organism they were dealing with wasVibrio fetus. Vibrio fetusinfection is well known to the veterinarian as a common cause of abortion in cattle and sheep. There have been at least 75 reported cases of human infection including cases of sepsis (1-3), meningoencephalitis (2, 4), and endocarditis (5). The...References1. TOALAMCDONALDKASS PAE: Septicemia caused by Vibrio fetus. Arch Intern Med 126:306-308, 1970 CrossrefMedlineGoogle Scholar2. COLLINSBLEVINSBENTER HAE: Protracted bacteremia and meningitis due to Vibrio fetus. Arch Intern Med 113:361-364, 1964 CrossrefMedlineGoogle Scholar3. FRANKLINULMER BD: Human infection with Vibrio fetus. West J Med 120:200-204, 1974 MedlineGoogle Scholar4. GUNDERSONSACK CG: Neurology of Vibrio fetus infection. Neurology 21:307-309, 1971 CrossrefMedlineGoogle Scholar5. LOEBBETTAGJUNG HJN: Vibrio fetus endocarditis. Am Heart J 71:381-386, 1966 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MICHAEL SANDS, M.D.Affiliations: Tulane University School of Public Health and Tropical Medicine New Orleans, Louisiana 70130 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCampylobacter species isolated from extra-oro-intestinal abscesses: a report of four cases and literature reviewCampylobacter fetus ssp. fetus brain abscessNon-Cholera Vibrio Infections in the United States Clinical, Epidemiologic, and Laboratory FeaturesJAMES M. HUGHES, M.D., DANNIE G. HOLLIS, M.S., EUGENE J. GANGAROSA, M.D., ROBERT E. WEAVER, M.D., Ph.D. 1 January 1975Volume 82, Issue 1Page: 124-124KeywordsEndocarditisFetusesMeningoencephalitisSepsisVibrio ePublished: 1 December 2008 Issue Published: 1 January 1975 PDF downloadLoading ...
DOES FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY GUIDED MANAGEMENT IMPROVE QUALITY OF LIFE IN PATIENTS WITH LEFT VENTRICULAR DYSFUNCTION? A QUALITY OF LIFE SUBSTUDY OF THE PARR2 TRIAL
Authors: Tushar Shukla, Graham Nichol, George Wells, Linda Garrard, Ann Guo, Ross Davies, Haissam Haddad, Lloyd Duchesne, Michael Freeman, Karen Gulenchyn, Normand Racine, Dennis Humen, Robert deKemp, Li Chen, Terrence Ruddy, Benjamin Chow, Jean DaSilva, Rob Beanlands
Journal: Journal of the American College of Cardiology (2011)
AAV vector re-targeting: A small step on the way to cardiac-specific gene transfer
Authors: A GODECKE
Journal: Cardiovascular Research (2006)

See article by Muller et al.  [8]  (pages 70–78) in this issue .

Gene and stem cell therapy are two visions of modern medicine that could have the potential to redirect patient treatment from a pharmacological/interventional to a molecular approach. The idea behind both strategies is the perspective to causally treat disease. Both visions are attractive, both promise causal therapies. Therefore, it is not too astonishing that both approaches have caused hopes and hypes. However, as sometimes observed when a new field moves from the first spectacular results into broader investigation, problems and pitfalls become apparent that dampen the expectations of fast solutions.

In 1999, the field of gene therapy was shaken by the case of Jesse Gelsinger, who died in a clinical gene therapy trial for liver disease. Three years later, in French clinical trials to cure children with severe combined immunodeficiency, three children treated with retrovirally transduced cells developed cancer, most likely as a result of insertional mutagenesis by the retrovirus. Consequently, gene therapy trials were put on hold and doubts came up whether gene therapy represents a realistic future option in medicine [1]. These cases also showed in a tragic manner the need to send researchers from the bedside back to the bench to solve basic problems of somatic gene therapy.

In general, somatic gene therapy requires the solution of a complex set of problems that are all connected to the following three questions briefly addressed below:

1.  What is my therapeutic gene?
        The identification of the therapeutic gene is, of course, closely related to the biological dysfunction that is to be cured. In the cardiovascular field, … 

* Corresponding author. Tel.: +49 211 8112675; fax: +49 211 8112675. Email address: Axel.Goedecke{at}uni-duesseldorf.de
Long-Term Outcomes by Clopidogrel Duration and Stent Type in a Diabetic Population With De Novo Coronary Artery Lesions
Authors: Somjot S. Brar, John Kim, Simerjeet K. Brar, Ray Zadegan, Michael Ree, In-Lu A. Liu, Prakash Mansukhani, Vicken Aharonian, Ric Hyett, Albert Yuh-Jer Shen
Journal: Journal of the American College of Cardiology (2008)
Association between hepatitis B virus infection and HLA-DR type in Korea
Authors: Sang Hoon Ahn, Kwang-Hyub Han, Jeong Youp Park, Chun Kyon Lee, Shin Wook Kang, Chae Yoon Chon, Yu Seun Kim, Kiil Park, Dong Kee Kim, Young Myoung Moon
Journal: Hepatology (2000)

Although the mechanism of susceptibility to chronic persistent hepatitis B virus (HBV) infection is not well clarified, immunogenetic factors of the host may have a role. Recently, a strong association between HLA-DR13 and the self-limited course of HBV infection has been reported. To determine whether the elimination of HBV is related to a particular HLA allele, we studied the HBV markers and HLA-DR phenotypes of 1,272 Koreans who had visited Yonsei University Medical Center for renal transplantation. They included 330 renal transplant donors. Subjects were categorized into 3 different groups: the "Unexposed Group" (UE; n = 946) with negative HBV markers, the "Chronic Carrier Group" (CC; n = 83), who were hepatitis B surface antigen (HBsAg)-positive, and the "Spontaneously Cleared Group" (SC; n = 243), who were HBsAg-negative with antibodies to HBsAg (anti-HBs) and hepatitis B core antigen (anti-HBc). HLA-DR4 was the most common type in all groups. HLA-DR6 was significantly more frequent in 69 of 243 subjects with SC (28. 4%) than in 8 of 83 subjects with CC (9.6%) (P <.001; relative risk [RR] = 3.72). HLA-DR9 was significantly more frequent in CC than in SC (P <.001; RR = 0.33). HLA-DR13 showed a stronger association with the clearance of HBV than the other HLA-DR6 subgroup. The distribution of HLA-DR phenotypes was similar regardless of renal disease. Our data indicate that HLA-DR6, especially HLA-DR13, is one of the host factors, which influences the immune response to HBV, and may be associated with self-elimination of HBV in Koreans.
Histamine and thrombin modulate endothelial focal adhesion through centripetal and centrifugal forces.
Authors: A B Moy, J Van Engelenhoven, J Bodmer, J Kamath, C Keese, I Giaever, S Shasby, D M Shasby
Journal: Journal of Clinical Investigation (1996)

We examined the contribution of actin-myosin contraction to the modulation of human umbilical vein endothelial cell focal adhesion caused by histamine and thrombin. Focal adhesion was measured as the electrical resistance across a cultured monolayer grown on a microelectrode. Actin-myosin contraction was measured as isometric tension of cultured monolayers grown on a collagen gel. Histamine immediately decreased electrical resistance but returned to basal levels within 3-5 min. Histamine did not increase isometric tension. Thrombin also immediately decreased electrical resistance, but, however, resistance did not return to basal levels for 40-60 min. Thrombin also increased isometric tension, ML-7, an inhibitor of myosin light chain kinase, prevented increases in myosin light chain phosphorylation and increases in tension development in cells exposed to thrombin. ML-7 did not prevent a decline in electrical resistance in cells exposed to thrombin. Instead, ML-7 restored the electrical resistance to basal levels in a shorter period of time (20 min) than cells exposed to thrombin alone. Also, histamine subsequently increased electrical resistance to above basal levels, and thrombin initiated an increase in resistance during the time of peak tension development. Hence, histamine and thrombin modulate endothelial cell focal adhesion through centripetal and centrifugal forces.
Seasonal trends in house dust mite allergen in children’s beds over a 7‐year period
Authors: D. Crisafulli, C. Almqvist, G. Marks, E. Tovey
Journal: Allergy (2007)

Background: House dust mite (HDM) allergy is closely linked to the expression of asthma and other allergic diseases. Understanding factors influencing variation in allergen may help in controlling allergic disease. The objective of this study was to investigate the effects of seasonal changes in climate, type of bed used in very early childhood and anti‐mite interventions on HDM allergen concentration. Methods: Participants were enrolled in a randomized‐controlled trial of HDM avoidance. Der p 1 was measured in dust samples from children’s beds on 13 occasions, from birth to age 5 years, between 1997 and 2004. Bed types were categorized as bassinette, cot or bed. The effects of study month, type of bed and intervention group on HDM allergen concentration were estimated by multiple linear regression. The relation between climatic variables and HDM allergen concentration was investigated using a polynomial distributed lag model. Results: House dust mite allergen concentrations were initially low in cots and bassinettes in 1997/1998, peaked in bassinettes and beds between 1999 and 2001 and then slowly declined during the period 2002/2004. Seasonal fluctuations occurred with minima in summer and two‐ to threefold higher maxima during late autumn. Allergen peaks were correlated with relative humidity peaks 2 months previously. Seasonal changes in allergen were not affected by the HDM avoidance intervention. Conclusions: House dust mite allergen concentrations in Sydney beds fluctuate approximately two‐ to threefold on an annual cycle, partly determined by relative humidity, with peaks in late autumn and minima in summer. Fluctuations of this magnitude might be sufficient to influence asthma symptoms.