tbuckley/cabot-search huggingface dataset:
Simultaneous PET-MRI: a new approach for functional and morphological imaging
Authors: Martin S Judenhofer, Hans F Wehrl, Danny F Newport, Ciprian Catana, Stefan B Siegel, Markus Becker, Axel Thielscher, Manfred Kneilling, Matthias P Lichy, Martin Eichner, Karin Klingel, Gerald Reischl, Stefan Widmaier, Martin Röcken, Robert E Nutt, Hans-Jürgen Machulla, Kamil Uludag, Simon R Cherry, Claus D Claussen, Bernd J Pichler
Journal: Nature Medicine (2008)
VIBRIOS FROM CALVES AND THEIR SEROLOGICAL RELATION TO VIBRIO FETUS
Authors: Theobald Smith, Marion L. Orcutt
Journal: The Journal of Experimental Medicine (1927)

The calf vibrios thus far studied include one strain serologically distinct from the fetal strains. The others are closely related to the fetal strains though not identical with them. The pathogenic characters of the calf vibrios, either as possible descendents of Vibrio fetus, or as independent factors in the production of enteritis have not been demonstrated.
London's health care.
Authors: I. Woolf
Journal: BMJ (1992)

gastric motility as observed in states of reduced dietary intake such as anorexia nervosa.' Un- fortunately, Chua and colleagues do not report dietary data or body mass indices.All functional diseases must ultimately be explicable in terms of biochemical phenomena.Do patients benefit more, however, from the comfortable assertion that they have a "neuro- transmitter problem" and the pharmacological treatments that this inevitably suggests or by doctors addressing the psychosocial stressors that underlie or exacerbate the diseases?Evidence suggests that accepting a medicalising label and its attendant invalid role may be associated with delayed recovery in patients without demonstrable organic disease.'
Behavioral Therapy for Urinary Incontinence
Authors: F. Craig Fisher
Journal: JAMA (1989)

<h3>To the Editor.—</h3> In the article entitled "A Clinical Trial of a Behavioral Therapy to Reduce Urinary Incontinence in Nursing Homes,"<sup>1</sup>many of us would consider the three patients who dropped out because they underwent catheterization by their family physicians as the experimental group and the rest as control subjects. Were the patients who underwent catheterization in fact easier to care for, less dependent, more satisfactory aesthetically for the staff and less arduous to manage, and, with a diminished dependency on the staff, happier patients? Or were they made sicker and did they die sooner and in a less pleasant manner than those who were left to be incontinent? Is denial of catheterization for incontinent patients in nursing homes a shibboleth? Or does it represent "best medicine?" I believe more attention should be paid to the benefits and demerits of this simple solution to incontinence, before dismissing it as
Air filtration for asthma.
Authors: M A Denborough
Journal: BMJ (1971)

fibrosing alveolitis"8 with the addition of giant cells.In immune disease stimulation and later failure of affected endocrines may be a by-product of the antibody response.Preliminary studies by me of three thyroid patients showed reversal of hyperthyroidism on 15 mg daily of prednisone.The first case, with sarcoid hyperthyroidism, remains euthyroid three months after prednisone was withdrawn.Massive doses of steroids are not always necessary to "block" the thyroid overaction.Hyperthyroidism complicated by temporary myasthenia is rare, but early in- vestigation is important because it may be caused by sarcoidosis.Steroid treatment of myasthenia gravis may be more effective if started sooner.-Iam, etc.,
IMPACT OF DURATION OF STATIN MEDICATION ON CLINICAL OUTCOMES IN PATIENTS UNDERGOING PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY FOR ATHEROSCLEROTIC PERIPHERAL ARTERIAL DISEASE
Authors: Sang-Ho Park, Seung-Woon Rha, Woong Jeon, Dongkyu Jin, Byoung Geol Choi, Se Yeon Choi, Shaopeng Xu, Harris Ngow Abdullah, Jae Joong Lee, Sunki Lee, Ji Bak Kim, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong-Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2015)
Treatment of the Low-Salt Syndrome in Congestive Heart Failure by the Controlled Use of Mercurial Diuretics
Authors: ALBERT L. RUBIN, WARREN S. BRAVEMAN
Journal: Circulation (1956)

The production of the low-salt syndrome in cardiac patients with refractory congestive heart failure is generally attributed either to fluid retention with electrolyte dilution or to excessive salt loss, induced by the frequent administration of mercurial diuretics. The former is often the important etiologic factor. In a study of a group of 25 refractory cardiac patients with normal plasma electrolyte patterns, a hyperchloremic acidosis was produced to restore a responsiveness to mercurial diuretics. During the mercurial-induced diuresis that followed, the urinary sodium concentration was significantly lower than the plasma sodium concentration in all instances. From these observations, a method of treatment of the low-salt syndrome, utilizing mercurial diuretics seemed feasible. This regimen was successfully carried out in two hyponatremic patients with return of plasma sodium to normal and striking clinical improvement.
Pesticide Exposure and Hypertensive Disorders During Pregnancy
Authors: Tina M. Saldana, Olga Basso, Donna D. Baird, Jane A. Hoppin, Clarice R. Weinberg, Aaron Blair, Michael C.R. Alavanja, Dale P. Sandler
Journal: Environmental Health Perspectives (2009)

Hypertensive disorders of pregnancy, including pregnancy-induced hypertension (PIH) and preeclampsia (PE), complicate 2-8% of pregnancies. Few studies have examined environmental risk factors in relation to these conditions.Our goal was to examine whether pesticide exposure during pregnancy was associated with hypertensive disorders of pregnancy.We analyzed self-reported data from 11,274 wives of farmers enrolled in the Agricultural Health Study (AHS) between 1993 and 1997. Using logistic regression models, we estimated the adjusted odds ratios (AORs) for PIH and PE associated with pesticide-related activities during the first trimester of pregnancy.First-trimester residential and agricultural activities with potential exposure to pesticides were associated with both PIH [residential AOR = 1.27; 95% confidence interval (CI), 1.02-1.60; agricultural AOR = 1.60; 95% CI, 1.05-2.45] and PE (residential AOR = 1.32; 95% CI, 1.02-1.70; agricultural AOR = 2.07; 95% CI, 1.34-3.21).Exposure to pesticides during pregnancy may increase the risk of hypertensive disorders of pregnancy. Laboratory research may provide insights into relationships between pesticide exposure and hypertensive diseases of pregnancy.
Deranged platelet calcium homeostasis in diabetic patients with end-stage renal failure: A possible link to increased cardiovascular mortality?
Authors: Aurelio M Vicari, Maria V Taglietti, Fabio Pellegatta, Donatella Spotti, Marco Melandri, Laura Galli, Paola Ronchi, Franco Folli
Journal: Diabetes Care (1996)

OBJECTIVE Platelet hyperfunction is a typical feature of the prothrombotic state that frequently complicates the natural history of diabetes. In uremia, a bleeding diathesis is present, which principally involves the primary phase of hemostasis. Thus, in patients with uremia of diabetic origin, the infrequent coexistence of two opposite alterations of hemostasis takes place. In patients with uremia, an increased incidence of cardiovascular events and related mortality is observed. This phenomenon is greatly amplified in uremia of diabetic origin. Calcium homeostasis is a critical aspect of platelet function, which has recently become available in human diseases. The aim of this study was to evaluate calcium homeostasis in platelets from patients with uremia of diabetic and nondiabetic origin. RESEARCH DESIGN AND METHODS We evaluated, by means of Fura 2, the intracellular concentration of ionized calcium ([Ca2+]i) in platelets from 18 patients with uremia of diabetic origin, 12 patients with uremia of nondiabetic origin and 16 healthy control subjects [Ca2+]i was evaluated in resting conditions and after stimulation with 0.05, 0.1, 0.5 U/ml thrombin. RESULTS Platelets from uremic patients with diabetes had higher resting [Ca2+]i than both control subjects (P = 0.01) and uremic patients without diabetes (P = 0.001). Similarly, after stimulation with thrombin, the absolute increase of [Ca2+]i was higher (P &amp;lt; 0.05) in platelets from uremic patients with diabetes compared with both control subjects and uremic patients without diabetes. The relative increase of [Ca2+]i was higher (P &amp;lt; 0.05) than normal in platelets from uremic patients after weak or intermediate strength thrombin. No correlation were present between [Ca2+]i values and other clinical and laboratory variables potentially associated with platelet hyperfunction. CONCLUSIONS Diabetes and uremia in combination further deteriorate the abnormal platelet calcium homeostasis observed in uremia.
The Keys to the House (Le Chiavi di Casa)
Authors: Khalid Ali
Journal: BMJ (2005)

Directed by Gianni Amelio UK release date: 1 April 2005 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> F ilms about disabled characters have rarely made entertaining cinema. Jim Sheridan's My Left Foot (1989) is an exception: its portrayal of the Irish artist and writer Christy Brown, whose cerebral palsy confined him to a wheelchair, won Daniel Day-Lewis a well deserved Oscar. About two children out of every thousand born in this country have some form of cerebral palsy. The Keys to the House , based on a book by Giuseppe Pontiggia about his relationship with his son, tells the story … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Complementary medicine and the general practitioner.
Authors: R Wharton, G Lewith
Journal: BMJ (1986)

The attitudes to complementary medicine of a random sample of general practitioners in Avon were assessed. A questionnaire was sent to 200 general practitioners, of whom 145 responded. The treatments studied were acupuncture, homoeopathy, herbal medicine, spinal manipulation, faith healing, and hypnosis. Of the 145 general practitioners, 55 (38%) had received some training in complementary medicine and 22 (15%) wished to arrange training. Overall, general practitioners knew little about the techniques of complementary medicine. Despite this 86 doctors (59%) thought that the complementary techniques being assessed were useful to their patients: 110 (76%) had referred patients for this type of treatment over the past year to medically qualified colleagues and 104 (72%) had referred patients to non-medically qualified practitioners. Most (93%) of those who responded believed that complementary practitioners needed statutory regulation; only 3% thought that they should be banned. The method of regulation most favoured was through a central and independent national body. General practitioners' views about complementary techniques were most influenced (in a positive manner) by observed benefits to their patients (41%) and personal or family experience of benefit (38%). The results of the study show a surprisingly high interest in complementary medicine among general practitioners in the Avon area.
Pacemaker in a Centenarian
Authors: Alfred S. Hartwell
Journal: JAMA (1971)

To the Editor.—  My colleague Niall C. Scully, MD, a thoracic surgeon in our clinic, implanted a pacemaker in a 96-year-old woman on Oct 8, 1968. She has done well since. One battery replacement has been made since. She became 99 years old in August 1971.
Hodgkin's Disease
Authors: Dane R. Boggs
Journal: JAMA (1981)

The first edition of this book, published in 1972, represented the first modern monograph to present comprehensive consideration of all aspects of Hodgkin's disease. Kaplan was, and is, somewhat uniquely suited to this task, being at the forefront of the basic and clinically oriented research that has led to the cure of Hodgkin's disease in many patients. Since he also writes well and is willing to give consideration to interpretations and conclusions that may conflict with his own, the book is a balanced and exhaustive effort. The second edition follows essentially the same format as the first, with material having been updated by rewriting sections in most instances, rather than by merely adding new material. In the eight years between editions, the changes in approach to patients with Hodgkin's disease have not been at all profound in a conceptual sense. However, Kaplan reviews the studies that have solidified certain previously
Histochemical and biochemical studies on the effect of the prostacyclin derivative iloprost on CCI4-induced lipid peroxidation in rat liver and its significance for hepatoprotection
Authors: Wilfried Bursch, Hendryk S. Taper, Marie P. Somer, Stefan Meyer, Barbara Putz, Rolf Schulte-Hermann
Journal: Hepatology (1989)

In the present study, it was investigated whether the prostacyclin derivative Iloprost would protect hepatocytes against CCl4-induced liver injury and which mechanism(s) of hepatocellular pathogenesis might be affected by it. Rats were treated with a single oral dose of CCl4 (2 ml per kg); Iloprost was infused continuously from 2 to 4 hr before intoxication until killing. The following results were obtained. The CCl4-induced release of AST, lactate dehydrogenase and alkaline phosphatase into the serum was reduced by 50 to 70% in rats treated with doses of 0.1 and 0.5 micrograms Iloprost per kg per min. Infusion of 0.02 and 0.004 micrograms Iloprost per kg per min did not affect the CCl4-induced enzyme release into the blood. CCl4 induced the occurrence of aldehydes (products of lipid peroxidation), which were detected by histochemical and biochemical means. At 12, 48 and 72 hr after CCl4, the aldehyde-positive liver section area was about 58, 69 and 16% in rats treated with CCl4 alone, but only about 18, 13 and less than 1% in rats treated additionally with Iloprost. The aldehyde-positive hepatocytes were located predominantly in the centrilobular zone of the liver. At 24 hr the extent of the aldehyde-positive section area was the same in rats with or without Iloprost treatment (about 90%). Biochemical determination, however, revealed that at this time point the malondialdehyde content after Iloprost in rats was about 70% lower than without Iloprost treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
Abstract LB-116: Cep55, a master regulator of cytokinesis in breast cancer pathogenesis
Authors: Murugan Kalimutho, Jacinta Simmons, Winnie Fernando, Jodi Saunus, Kevin Spring, Sunil Lakhani, Fares Al-Ejeh, Kum Kum Khanna
Journal: Cancer Research (2014)

Abstract Defects in the number, structure, and function of centrosomes can generate mono- or multipolar mitotic spindles and cytokinesis failure resulting in aneuploidy and chromosome instability, which are common characteristics of tumour cells. Centrosomal proteins thus play central roles in the execution of proper cell division. Cep55 is a centrosomal protein required for proper segregation of two daughter cells during cytokinesis. It often elevated in wide range of cancer types including breast cancer. To ascertain the functional role of Cep55 in breast cancer pathogenesis, we performed publically available data mining as well as IHC staining in a cohort of breast cancer patients and found that elevated levels of Cep55 is significantly associated with p53 mutation, basal like subtype, relapse free and distant-metastasis free survival. Immunoblot analysis of non-malignant and breast cancer cell lines revealed higher expression of Cep55 protein in basal like subtype. RNAi mediated Cep55 depletion in cultured human breast cancer cells resulted in decreased cell proliferation, induction of apoptosis in-vitro and failure to establish xenografts in-vivo. Moreover, these cells failed to establish lung colonisation due to less proliferative, migrative and invasive capacity in experimental metastasis models. In an initial effort to identify causal effective of Cep55 mediated breast cancer pathogenesis, we found that Cep55-depleted cells that survive following long term culture have restored their ploidy compared with aneuploid cells that have constitutively high levels of Cep55. Moreover, these non-tumorigenic cells also have defect in major signalling networks assessed by Kinexus proteomic array. In line with this finding, we found that constitutive overexpression of Cep55 in non-transformed mammary epithelial cells, MCF-10a induced ERK1/2 and STAT3 signalling possibly due to increase in chromosome instability. Taken together, these results indicate that Cep55 promotes breast cancer initiation, progression and lung colonisation through pleiotropic effect and genomic instability that likely contribute to aneuploidy state of breast cancer tumours Citation Format: Murugan Kalimutho, Jacinta Simmons, Winnie Fernando, Jodi Saunus, Kevin Spring, Sunil Lakhani, Fares Al-Ejeh, Kum Kum Khanna. Cep55, a master regulator of cytokinesis in breast cancer pathogenesis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-116. doi:10.1158/1538-7445.AM2014-LB-116
Pop Bottle Explosions
Authors: Ervin Epstein
Journal: JAMA (1978)

To the Editor. —  The article Pop Bottle Explosions by Bergeson et al was very interesting and up-to-date (238:1048, 1977). Unfortunately, they missed an important cause of such accidents by limiting their search of the literature, with their first reference being from 1962. I would like to mention two quotes from my 1955 article1:  Glass... is soluble in water. This process is slow but definite. This reaction can be accelerated by changing the water frequently.... An actual hydrolysis takes place forming silica and certain soluble salts. This is strengthened in an alkali medium.  If, for instance, you examine a bottle that has contained water for a long period of time, you will see etching on the inner surface due to actual dissolving of the glass on the surface by the water. There has been a great deal of legal difficulty caused by soft drink bottles 'exploding' while being held
636. Long Term Elevation of HDL Cholesterol Induced by Rabbit apo A-I or Rabbit LCAT Gene Transfer Inhibits Media Thinning in a Rabbit Model of Advanced Atherosclerosis
Authors: Joke Lievens, Jan Snoeys, Yingmei Feng, Désiré Collen, Bart De Geest
Journal: Molecular Therapy (2005)

Background: High density lipoprotein (HDL) cholesterol is the most powerful predictor of ischemic cardiovascular diseases in humans. Dyslipidemic rabbits are a more appropriate model of human dyslipidemia and atherosclerosis than mice. In contrast to mice and similar as humans, rabbits express cholesteryl ester transfer protein and rabbit liver does not edit apolipoprotein (apo) B mRNA. The purpose of this study was to evaluate the effect of rabbit apo A-I and rabbit lecithin:cholesterol acyltransferase (LCAT) transfer on the lipoprotein profile and on atherosclerosis in rabbits.
Editorial note on results of assisted dying poll
Authors: T. Delamothe
Journal: BMJ (2012)

The voting in the poll “Should doctors’ organisations be neutral on assisted dying?”, which ran on bmj.com during 14-25 June 2012, was Yes: 1137 (17%) and No: 5455 (83%).1

Of the total 6592 respondents, some 72% were from the UK; we …
Detection of immune complexes in serum of patients with ankylosing spondylitis.
Authors: V Corrigall, G S Panayi, A Unger, R N Poston, B D Williams
Journal: Annals of the Rheumatic Diseases (1978)

Immune complexes were measured in the sera of 18 patients iwth ankylosing spondylitis and 5 normal control subjects by their ability to inhibit antibody-mediated lymphocyte-induced cytotoxicity. 11 of the spondylitis and none of the control sera contained circulating complexes. Fractionation of sera on Sephadex G-200 showed that complexes were of two molecular sizes, one of intermediate and the other of large molecular weight. The presence of immune complexes did not correlate with activity of disease or the presence of peripheral arthritis although the one patient with polyarthritis had the highest level of complexes detected in this study. The nature of the antigen in these antigen-antibody complexes is of great interest since it may provide evidence of the aetiological agent in the disease.
Comparison of HIV-Antibody Prevalence in Patients Consenting to and Declining HIV-Antibody Testing in an STD Clinic
Authors: Harry F. Hull
Journal: JAMA (1988)

All patients attending a sexually transmitted disease (STD) clinic were offered voluntary, anonymous human immunodeficiency virus (HIV)—antibody testing and counseling as part of routine clinical evaluation. During a three-month evaluation period, 82% of patients accepted HIV testing. Testing was accepted equally by men and women and by heterosexual and homosexual men. Black men were more likely to refuse testing than men from other ethnic groups. Eight (0.7%) of 1146 STD clinic patients tested were infected with HIV. A blinded study of 237 patients who refused testing identified nine (3.8%) additional HIVinfected patients. Men who refused testing were 5.3 times more likely to be infected than men who accepted testing. Male homosexuals and black and Hispanic men who refused testing were 7.3 and 8.8 times, respectively, more likely to be infected with HIV than were their counterparts who accepted testing. Human immunodeficiency virus testing and counseling should be routinely offered to STD clinic patients. Male STD clinic patients, especially homosexual or minority men, who refuse voluntary HIV testing should be counseled regarding reducing their risk for HIV transmission. (<i>JAMA</i>1988;260:935-938)
Worksite Wellness Programs: Latest Wrinkle to Smooth Health Care Costs
Authors: Marsha F. Goldsmith
Journal: JAMA (1986)

"WELLNESS" is what they call the latest appeal to Americans' belief in human perfectibility, and it's not to be confused with health. Almost anyone left to his or her own devices just might coast along feeling healthy, but—according to advocates of this approach—wellness is something one has to work at. In fact, it's at work that many people think wellness counts most. Some 370 participants in a recent conference in Omaha called "Health-Task '86: Working for Wellness" were exhorted time and again to spur the persons under their direction toward achieving "wellness at the worksite." The conference was sponsored by the Health Insurance Association of America (HIAA) and the Wellness Council of the Midlands (WELCOM). Much of the support for the movement comes from the health and life insurance industry under the reasonable assumption that people who are well tend to require less medical care and die after paying more
Intraluminal transport of iron from stomach to small-intestinal mucosa
Authors: A. Jacobs, P. M. Miles
Journal: BMJ (1969)

Inorganic iron rarely exceeds 10(-4) molar concentration in the stomach after a meal. Natural sugars, ascorbic acid, citric acid, and amino-acids form iron complexes, and if they are present in the meal complexing occurs when the gastric contents are neutralized. In their absence an iron complex is formed with gastric mucopolysaccharide, which acts as a carrier, stable at neutral pH. Iron can be detached from this carrier at neutral pH by some low molecular weight substances, of which citric acid, ascorbic acid, and cysteine are particularly effective at low concentrations. Under normal circumstances most of the iron released from food in the stomach becomes bound to the mucopolysaccharide carrier.
Myocardial velocity gradient as a new indicator of regional left ventricular contraction: Detection by a two-dimensional tissue doppler imaging technique
Authors: Masaaki Uematsu, Kunio Miyatake, Norio Tanaka, Hisao Matsuda, Akihiro Sano, Nobuo Yamazaki, Makoto Hirama, Masakazu Yamagishi
Journal: Journal of the American College of Cardiology (1995)