tbuckley/cabot-search huggingface dataset:
Positive and Negative Inotropic Responses of the Atria and Ventricles to Vagosympathetic Stimulation in the Isovolumic Canine Heart
Authors: Donald V. Priola, Robert L. Fulton, Constantine Anagnostelis
Journal: Circulation Research (1969)

The responses of the paced, isovolumic atria and ventricles to cervical vagosympathetic stimulation were examined in eight normal and seven sympathectomized dogs under chloralose anesthesia. Before atropine, stimulation usually caused decreases in both atrial and ventricular contractility but with significant quantitative and qualitative variation from animal to animal. The right atrium showed the greatest average decrease (&gt;30%), followed by the left atrium (12%), right ventricle (4% to 12%), and the left ventricle (1% to 10%). After atropine, 0.5 mg/kg, all chambers responded positively to stimulation. The right ventricle was most responsive (about 30%), and the other chambers showed increases of 10% to 20%. These positive inotropic responses were eliminated by propranolol, 0.5 mg/kg, or by pentolinium tartrate, 0.5 mg/kg. In the sympathectomized animals, negative inotropic responses were usually greater and positive responses were reduced or eliminated. The data demonstrate that fibers exist in the cervical vagosympathetic trunks which have both negative and positive inotropic effects on all chambers of the heart. The net effect of vagosympathetic stimulation on a chamber's contractility reflects the relative numbers of the two fiber types which supply it. The fibers mediating the positive effects are probably preganglionic with significant postganglionic stations in the caudal cervical and stellate ganglia and perhaps in the heart itself.
Guidelines of care for superficial mycotic infections of the skin: Onychomycosis
Authors: None Guidelines/Outcomes Committee, Lynn A Drake, Scott M Dinehart, Evan R Farmer, Robert W Goltz, Gloria F Graham, Maria K Hordinsky, Charles W Lewis, David M Pariser, John W Skouge, Stephen B Webster, Duane C Whitaker, Barbara Butler, Barbara J Lowery, None Task Force, Boni E Elewski, Mervyn L Elgart, Paul H Jacobs, Jack L Lesher, Richard K Scher
Journal: Journal of the American Academy of Dermatology (1996)
Anesthesia for Cataract Surgery-Reply
Authors: Ray J. DeFalque
Journal: JAMA (1986)

<h3>In Reply.—</h3> Skill and compassion are, of course, essential in treating patients under local anesthesia. Diazepam is a good premedication, but it occasionally causes confusion in old persons and may have very prolonged effects, two undesirable features in outpatient eye surgery performed with local anesthesia. I prefer not to have the patient react or move during insertion of the needle into the retrobulbar space, and this rarely occurs with our regimen. I disagree with Dr Winchell that the very transient depth of anesthesia sufficient to insert a soft nasal airway (and to prevent the patient from reacting to the needle stabs) must mean hypotension and hypoxia, nor do I find this to be the case when blood pressure and blood gas values are checked. The drug dosages I suggested were average figures and will produce in a rare patient deeper and more prolonged anesthesia than anticipated. A skillful physician, experienced
Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia
Authors: Richard C. Harvey, Charles G. Mullighan, I-Ming Chen, Walker Wharton, Fady M. Mikhail, Andrew J. Carroll, Huining Kang, Wei Liu, Kevin K. Dobbin, Malcolm A. Smith, William L. Carroll, Meenakshi Devidas, W. Paul Bowman, Bruce M. Camitta, Gregory H. Reaman, Stephen P. Hunger, James R. Downing, Cheryl L. Willman
Journal: Blood (2010)
Therapeutic Non-equivalence of Digoxin Tablets in United Kingdom: Correlation with Tablet Dissolution Rate
Authors: T. R. D. Shaw, K. Raymond, M. R. Howard, J. Hamer
Journal: BMJ (1973)

Seven types of digoxin 0·25 mg tablet in common use in the United Kingdom were administered to a total of 38 patients. Significant differences were found in the mean plasma digoxin levels and in the control of atrial fibrillation achieved with these brands. There was a close correlation between the dissolution rate of the tablets and the plasma digoxin levels. Measurement of in-vitro dissolution rate appears to be a valid method of ensuring that different tablets of digoxin are of equal efficacy. However, in some patients absorption of the drug is markedly sensitive to changes in dissolution rate and new pharmacopoeal standards should not be defined until very rapidly-dissolving formulations have been studied.
Onward Howard Kelly, Marching as to War
Authors: Howard Markel
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
President's address. Weathering the storm
Authors: H. L. Rogers
Journal: JAMA (1985)

One of the principal joys of being elected to the office of President of this Association is that it allows me to talk before many audiences of doctors. I would like to assure you that no group of physicians—and in this case, I would also include outstanding laymen—exceeds this one on my personal list of important audiences. On the subject of being elected, by the way, I would like to give you something to look forward to. I have the honor of being the third President of the AMA from Georgia. It took 37 years for us to elect the first one, in 1884. Fifty-nine years later, the second one took office. And in only 42 more years, here I am. I would just like to point out that if you average those periods of time, you can expect to elect another Georgia President in 46 years. However, we Georgia
Spleen Simulating Vascular Renal Mass in Left Renal Agenesis
Authors: EN-LIN YEH, G POHLMANN, ROBERT C. MEADE
Journal: Clinical Nuclear Medicine (1977)

In a case of left renal agenesis, the spleen was located in the posterior projection in the left renal region. The radionuclide renal angiogram and static renal images were misinterpreted as indicating a vascular renal mass. It is important to identify the kidney, spleen and heart in renal imaging.
Diverticulum of the Prostatic Urethra with Unusual Extension
Authors: Warren J. Brooker
Journal: JAMA (1962)

DIVERTICULA OF THE MALE URETHRA are not commonly encountered in urology and are certainly less frequently seen or recognized in other medical fields. The word originates from the Latin verb,<i>diverticul</i>âre—"to turn aside," and may be defined as a saclike protrusion continuous with the lumen of any portion of the urethra. When found in the male, approximately 60 per cent arise from the anterior urethra and may be either congenital or acquired in origin. The acquired group is usually associated with trauma or instrumentation and occurs in the third and fourth decades of life as distinguished from the congenital group which is discovered in the first and second decades. Common factors in the etiology are distal obstruction, infection, and calculus formation. Diverticula arising from the posterior urethra have been described for many years, as in the case described by Rourdillat in 1869 whose patient developed an urethrorectal fistula by erosion
Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling
Authors: Christina Gewinner, Zhigang C. Wang, Andrea Richardson, Julie Teruya-Feldstein, Dariush Etemadmoghadam, David Bowtell, Jordi Barretina, William M. Lin, Lucia Rameh, Leonardo Salmena, Pier Paolo Pandolfi, Lewis C. Cantley
Journal: Cancer Cell (2009)
Drug Eruption Reference Manual 1997
Authors: Steven Goldberg
Journal: Annals of Internal Medicine (1997)

Medical Writings15 December 1997Drug Eruption Reference Manual 1997Steven Goldberg, MDSteven Goldberg, MDKaiser Permanente, San Diego, CaliforniaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-12-199712150-00048 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Litt JZ, Pawlak WA Jr. 510 pages. New York: Parthenon; 1997. $149.00. ISBN 1850709076. Order phone 800-735-4744.Field of medicine: Dermatology and pharmacology.Format: Softcover book.Audience: Dermatologists and other interested physicians.Purpose: To provide the clinician with a reference for determining which drugs may produce any given skin eruption.Content: The book provides an alphabetical listing of more than 500 commonly prescribed drugs. Each drug is presented with its generic name, all of its known trade names, and the pharmacologic category or class to which it belongs. Cutaneous reaction patterns are listed, with references arranged chronologically. An excellent section ... Author, Article, and Disclosure InformationAffiliations: Kaiser Permanente, San Diego, California PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1997Volume 127, Issue 12Page: 1140KeywordsAdverse reactionsDermatologyDrugsMucous membranesPharmacology Issue Published: 15 December 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Low Rate of Postpolypectomy Bleeding Among Patients Who Continue Thienopyridine Therapy During Colonoscopy
Authors: Linda A. Feagins, Ramiz Iqbal, William V. Harford, Akeel Halai, Byron L. Cryer, Kerry B. Dunbar, Raquel E. Davila, Stuart J. Spechler
Journal: Clinical Gastroenterology and Hepatology (2013)
Searching for Reliable Epidermal Growth Factor Receptor Response Predictors
Authors: Paul M. Harari, Shyh-Min Huang
Journal: Clinical Cancer Research (2004)

Many years before the term “molecular targeting” was popularized in cancer therapeutics, the epidermal growth factor (EGF) and its receptor (EGFR or ErbB-1 or HER1) were recognized as important molecular regulators of cellular growth and differentiation [(1][1] [, 2)][2] . Today, the EGFR
STUDIES ON THE PREVENTION OF CHOLESTEROL ATHEROSCLEROSIS IN RABBITS
Authors: Kenneth B. Turner, George B. Khayat
Journal: The Journal of Experimental Medicine (1933)

1. Thyroidectomy in itself does not cause a rise in blood cholesterol or the development of atherosclerosis in young rabbits. 2. Feeding cholesterol produces hypercholesterolemia and atherosclerotic lesions in rabbits regardless of the presence or absence of the thyroid glands. 3. Potassium iodide prevents the usual hypercholesterolemia and atherosclerosis of the aorta in normal rabbits fed cholesterol, but when the thyroids are removed this protective action disappears.
Shock Associated With Barbiturate Intoxication
Authors: Herbert Shubin
Journal: JAMA (1971)

The patient who is admitted to the hospital with clinical signs of shock after barbiturate intoxication is characteristically in a state of deep coma. Corneal and deep tendon reflexes are absent and pupillary response to light is minimal. The rectal temperature is reduced to levels averaging only 95 F (35 C), and the skin is cool with the temperature in the ventrum of the great toes averaging only 79 F (26 C).<sup>1</sup>The skin of the earlobes, nose, or fingers is often cyanotic, reflecting the marked impairment in ventilation. A modest increase in heart rate is usually observed, but rates in excess of 130 beats per minute are uncommon. The systolic blood pressure is typically reduced to levels of less than 80 mm Hg. However, the values obtained with the sphymomanometer are usually 10 to 20 mm Hg less than those obtained on direct measurement after insertion of a
Terminal care for children dying of cancer: quantity and quality of life.
Authors: J A Kohler, M Radford
Journal: BMJ (1985)

Parents of 18 children who died of cancer in the last five years were interviewed. The mean duration of terminal care was 5.6 weeks, the median being two weeks. Most children died peace-fully at home after a brief but obvious period of deterioration. More counselling is needed for families in this situation.
The Effect of Oral Antidiabetic Agents on A1C Levels
Authors: Diana Sherifali, Kara Nerenberg, Eleanor Pullenayegum, Ji Emmy Cheng, Hertzel C. Gerstein
Journal: Diabetes Care (2010)

OBJECTIVE Previous reviews of the effect of oral antidiabetic (OAD) agents on A1C levels summarized studies with varying designs and methodological approaches. Using predetermined methodological criteria, we evaluated the effect of OAD agents on A1C levels. RESEARCH DESIGN AND METHODS The Excerpta Medica (EMBASE), the Medical Literature Analysis and Retrieval System Online (MEDLINE), and the Cochrane Central Register of Controlled Trials databases were searched from 1980 through May 2008. Reference lists from systematic reviews, meta-analyses, and clinical practice guidelines were also reviewed. Two evaluators independently selected and reviewed eligible studies. RESULTS A total of 61 trials reporting 103 comparisons met the selection criteria, which included 26,367 study participants, 15,760 randomized to an intervention drug(s), and 10,607 randomized to placebo. Most OAD agents lowered A1C levels by 0.5−1.25%, whereas thiazolidinediones and sulfonylureas lowered A1C levels by ∼1.0–1.25%. By meta-regression, a 1% higher baseline A1C level predicted a 0.5 (95% CI 0.1–0.9) greater reduction in A1C levels after 6 months of OAD agent therapy. No clear effect of diabetes duration on the change in A1C with therapy was noted. CONCLUSIONS The benefit of initiating an OAD agent is most apparent within the first 4 to 6 months, with A1C levels unlikely to fall more than 1.5% on average. Pretreated A1C levels have a modest effect on the fall of A1C levels in response to treatment.
Hair-grips as Foreign Bodies
Authors: R. H. Gardiner
Journal: BMJ (1955)

TRUE HERMAPHRODITISM X I-. 397 be considered in conjunction with all the available clin- ical evidence in deciding on the sex of upbringing.The diagnosis of true hermaphroditism rests finally on the histology of the gonads, but a tentative diagnosis may be made on clinical grounds.Fifty-nine previous cases of true hermaphroditism have been found in the literature.This small number is prob- ably not a true indication of the real incidence of the condition.I am indebted to Mr. L. R. Broster for permission to publish these cases under his care, and
RELATION OF THYROID AND PARATHYROID GLANDS TO CALCIUM AND PHOSPHORUS METABOLISM. STUDY OF A CASE WITH COEXISTENT HYPOPARATHYROIDISM AND HYPERTHYROIDISM
Authors: Oliver Cope, Gordon A. Donaldson
Journal: Journal of Clinical Investigation (1937)

The observations were carried out on E. M. G., an un- married woman of twenty-seven.(A complete protocol 0 IL4 z 0 z 0 z >4 z 0) H >4>4 .
Immunosuppressive drugs in rheumatoid arthritis.
Authors: A S Dixon, D J Lindsay, E M Collins
Journal: BMJ (1971)

pital as a day centre, but financed from hospital revenue.In a paper by us and C. M. Hyland3 the case was put that a day ward should not be provided by the hospital service to make up for the deficiencies of the welfare services, but should highlight these deficiencies so that they can be remedied.De Martino' stressed that as long as the finance of the National Health Service is divided into hos- pital, general practitioner, and local author- ity services, it is essential that the hospital service should spend its money only to per- form a hospital function.We wish to draw the attention of those in the specialty of geriatric medicine to the fallacious reasoning and inherent dangers of the Department of Health's current method of financing day hospital running costs, which will penalize the smaller and busier day hospital with a high turnover at the expense of the larger day centre type of day hospital.-Weare, etc.,
PRIMARY HEMANGIO-ENDOTHELIOSARCOMA OF THE LIVER
Authors: Charles S. White
Journal: JAMA (1933)

The infrequency of hemangio-endothelioma of the liver probably warrants reporting such a case, but its recognition as a medical entity is almost impossible and consequently detracts from its clinical interest. There seems to have been some confusion in the classification of several types of sarcomas and angiomas of the liver, although there is a great similarity in the microscopic picture. One gets the impression from the various pathologic descriptions that probably all have their origin in the walls of the liver capillaries, with great proliferation of endothelial cells and even the formation of many new blood vessels. The cells are morphologically sarcomatous in type and must be considered malignant, although in many of the cases no metastases were found, possibly because of the early death of the patient. In some of the cases reported more recently, metastases were found in the lungs, pancreas and retroperitoneal glands. The tumors have been
Oleate uptake by cardiac myocytes is carrier mediated and involves a 40-kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue, and gut.
Authors: D Sorrentino, D Stump, B J Potter, R B Robinson, R White, C L Kiang, P D Berk
Journal: Journal of Clinical Investigation (1988)

Uptake of [3H]oleate by canine or rat cardiac myocytes is saturable, displays the countertransport phenomenon, and is inhibited by phloretin and trypsin. Cardiac myocytes contain a basic (pI approximately 9.1) 40-kD plasma membrane fatty acid binding protein (FABPPM) analogous to those recently isolated from liver, adipose tissue, and gut, unrelated to the 12-14-kD cytosolic FABP in these same tissues. An antibody to rat liver FABPPM selectively inhibits specific uptake of [3H]oleate by rat heart myocytes at 37 degrees C, but has no influence on nonspecific [3H]oleate uptake at 4 degrees C or on specific uptake of [3H]glucose. Uptake of long-chain free fatty acids by cardiac muscle cells, liver, and adipose tissue and absorption by gut epithelial cells is a facilitated process mediated by identical or closely related plasma membrane FABPs.
Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease
Authors: Marion Dorsch, Gang Zheng, David Yowe, Prakash Rao, Yanjun Wang, Qiong Shen, Curran Murphy, Ximing Xiong, Qiuju Shi, Jose-Carlos Gutierrez-Ramos, Chris Fraser, Jean-Luc Villeval
Journal: Blood (2002)
The antiperinuclear factor: II. A light microscopical and immunofluorescence study on the antigenic substrate.
Authors: J W Smit, I R Sondag-Tschroots, C Aaij, T E Feltkamp, T M Feltkamp-Vroom
Journal: Annals of the Rheumatic Diseases (1980)

The antigenic substrate of the antiperinuclear factor (APF) in human buccal mucosa cells was studied by light microscopy, cytochemistry, and the immunofluorescence technique (IFT). The cytoplasmic granules against which the APF is directed stained basophilic in light-microscopical staining techniques. The granules did not show a positive reaction product by techniques in which special chemical components are stained, and no activity of lysosomal enzymes could be identified. The use of autoantibodies and other antisera directed to distinct tissues, components, or macromolecules did not resolve the character of the antigenic granules. In addition it was shown that human vaginal epithelial cells and cryostat sections of human and rabbit buccal and oesophageal mucosa incubated with APF-positive sera showed the same fluorescent granules in the IFT as human buccal mucosa cells. Cryostat sections of rabbit buccal and oesophageal mucosa were tested as an alternative substrate in the APF test. Since the specificity as well as the sensitivity decreased when these sections were used as a substrate, they are not suitable for diagnostic purposes.
Weak anti-HIV CD8+ T-cell effector activity in HIV primary infection
Authors: Marc Dalod, Marion Dupuis, Jean-Christophe Deschemin, Cécile Goujard, Christiane Deveau, Laurence Meyer, Nicole Ngo, Christine Rouzioux, Jean-Gérard Guillet, Jean-François Delfraissy, Martine Sinet, Alain Venet
Journal: Journal of Clinical Investigation (1999)

HIV-specific CD8+ T cells play a major role in the control of virus during HIV primary infection (PI) but do not completely prevent viral replication. We used IFN-γ enzyme-linked immunospot assay and intracellular staining to characterize the ex vivo CD8+ T-cell responses to a large variety of HIV epitopic peptides in 24 subjects with early HIV PI. We observed HIV-specific responses in 71% of subjects. Gag and Nef peptides were more frequently recognized than Env and Pol peptides. The number of peptides recognized was low (median 2, range 0–6). In contrast, a much broader response was observed in 30 asymptomatic subjects with chronic infection: all were responders with a median of 5 peptides recognized (range 1–13). The frequency of HIV-specific CD8+ T cells among PBMC for a given peptide was of the same order of magnitude in both groups. The proportion of HIV-specific CD8+CD28– terminally differentiated T cells was much lower in PI than at the chronic stage of infection. The weakness of the immune response during HIV PI could partially account for the failure to control HIV. These findings have potential importance for defining immunotherapeutic strategies and establishing the goals for effective vaccination.
How general practitioners can help subfertile couples.
Authors: R. Lilford, G. Young
Journal: BMJ (1992)

ship and the "specialness" of the attention that they received.Many patients cope by avoiding or denying their sexual feelings.9Others, feeling uncomfortable and unsafe with their sexuality, use it in chaotic, inappropriate, and self defeating ways.In working through feelings of shock, revulsion, and anger and re-examining issues of power, viol-ence, and sexism within society doctors may find their own sexual relationships affected and may go through a stage where they see abuse everywhere.'0They may find themselves "turned on" as much as "turned off" by accounts of the abuse and mistrust their own motives.The power and intensity of emotion experienced by both patient and doctor in the therapeutic relationship can be disturbing.Some of these feelings may remain unconscious but get acted on to the detriment of treatment-fdr example, doctors may inappropriately discharge or over investigate the patient.If the doctor can try to understand what is going on in his or her relationship with the patient and recognise the feelings that emerge as important clues about the patient's childhood then managing the patient will be far more re- warding and the patient's prognosis will be substantially improved.
Azathioprine-Induced Pure Red Blood Cell Aplasia
Authors: Christopher W. Old
Journal: JAMA (1978)

Pure RBC aplasia developed in two renal transplant recipients who were receiving long-term azathioprine therapy. With substitution of cyclophosphamide therapy for azathioprine, erythroid hyperplasia and reticulocytosis developed at three weeks in one patient and at three months in the other. Selective erythroid toxic reaction is a potential problem that must be considered when anemia develops in patients receiving long-term azathioprine therapy. (<i>JAMA</i>240:552-554, 1978)