tbuckley/cabot-search huggingface dataset:
Screening for Renovascular Hypertension
Authors: Sigmund Ruttiman
Journal: Annals of Internal Medicine (1993)

Letters1 June 1993Screening for Renovascular HypertensionSigmund Ruttiman, MD, Erich Steinmann, MD, and Thomas F. Luscher, MDSigmund Ruttiman, MDSearch for more papers by this author, Erich Steinmann, MDSearch for more papers by this author, and Thomas F. Luscher, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-11-199306010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In the excellent review article of renovascular hypertension by Mann and Pickering [1], the captopril test is proposed as a diagnostic tool to differentiate between renovascular and nonrenovascular hypertension, particularly in patients with a moderate index of clinical suspicion (5% to 15%). In patients where the prevalence is estimated to be 1% or less, the test is not recommended because of a low positive predictive value of 6.4% or less [1].We evaluated the usefulness of the captopril test [2] at our nonreferral general medical outpatient clinic in 141 consecutive patients who had newly detected hypertension or ...References1. Mann SJ, Pickering TG. Detection of renovascular hypertension. State of the art: 1992. Ann Intern Med. 1992; 117:845-53. Google Scholar2. Muller FB, Sealey JE, Case DB, Atlas SA, Pickering TG, Pecker MS, et al. The captopril test for identifying renovascular disease in hypertensive patients. Am J Med. 1986; 80:633-44. Google Scholar3. Pickering TG, Sos TA, Vaughan ED Jr, Case DB, Sealey JE, Harshfield GA, et al. Predictive value and changes of renin secretion in hypertensive patients with unilateral renovascular disease undergoing successful renal angioplasty. Am J Med. 1984; 76:398-404. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByThe Simplified Captopril Test: An Effective Tool to Diagnose Renovascular Hypertension 1 June 1993Volume 118, Issue 11Page: 905-906KeywordsAngiographyChartsHypertensionOutpatient clinicsPlasma renin activityPositive predictive valueRenal arteriesStenosis Issue Published: 1 June 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Electronic Medication Packaging Devices and Medication Adherence
Authors: Kyle D. Checchi, Krista F. Huybrechts, Jerry Avorn, Aaron S. Kesselheim
Journal: JAMA (2014)

Medication nonadherence, which has been estimated to affect 28% to 31% of US patients with hypertension, hyperlipidemia, and diabetes, may be improved by electronic medication packaging (EMP) devices (adherence-monitoring devices incorporated into the packaging of a prescription medication).To investigate whether EMP devices are associated with improved adherence and to identify and describe common features of EMP devices.Systematic review of peer-reviewed studies testing the effectiveness of EMP systems in the MEDLINE, EMBASE, PsycINFO, CINAHL, International Pharmaceutical Abstracts, and Sociological Abstracts databases from searches conducted to June 13, 2014, with extraction of associations between the interventions and adherence, as well as other key findings. Each study was assessed for bias using the Cochrane Handbook for Systematic Reviews of Interventions; features of EMP devices and interventions were qualitatively assessed.Thirty-seven studies (32 randomized and 5 nonrandomized) including 4326 patients met inclusion criteria (10 patient interface-only "simple" interventions and 29 "complex" interventions integrated into the health care system [2 qualified for both categories]). Overall, the effect estimates for differences in mean adherence ranged from a decrease of 2.9% to an increase of 34.0%, and the those for differences in the proportion of patients defined as adherent ranged from a decrease of 8.0% to an increase of 49.5%. We identified 5 common EMP characteristics: recorded dosing events and stored records of adherence, audiovisual reminders to cue dosing, digital displays, real-time monitoring, and feedback on adherence performance.Many varieties of EMP devices exist. However, data supporting their use are limited, with variability in the quality of studies testing EMP devices. Devices integrated into the care delivery system and designed to record dosing events are most frequently associated with improved adherence, compared with other devices. Higher-quality evidence is needed to determine the effect, if any, of these low-cost interventions on medication nonadherence and to identify their most useful components.
Diagnostic Exome Sequencing — Are We There Yet?
Authors: Heather C. Mefford
Journal: New England Journal of Medicine (2012)

Advances in technology are rapidly changing the field of medical genetics in both the research laboratory and the clinic. With the use of next-generation, or massively parallel, DNA sequencing, it is possible to determine the sequence of essentially all genes in an individual's genome — referred to as the exome — within a matter of days.This technology became widely available in 2005, and the first proof-of-principle experiment showing the power of exome sequencing for the discovery of genes associated with disease was published a few years later.1 Since then, exome analysis has been used in the research setting to . . .
Pregnancy-specific beta1-glycoprotein in plasma and tissue extract in malignant teratoma of the testis.
Authors: S A Johnson, J G Grudzinskas, Y B Gordon, A T Al-Ani
Journal: BMJ (1977)

CommentSP1 is one of a group of recently identified proteins ,synthesised by the human placenta," and it'has been given various names, including pregnancy-specific %-glycoprotein (PS G),2 and pregnancyassociated pla,sma protein' C (PAPP-C).5The SP, antigen has,, been on 18 July
Abstract B60: Oovarian mesenchymal stem cells secreted Interleukin-6 promotes the malignant transformation of serous ovarian cancer
Authors: Dah-Ching Ding, Tang-Yuan Chu
Journal: Clinical Cancer Research (2013)

Abstract Purpose: The IL-6/STAT3 signal plays a key role in the progression of serous carcinoma of the ovary. The role of ovarian stroma mesenchymal stem cells involving in this signaling and cancer progression is not known. Methods: Ovarian mesenchymal stem cells (OvMSC) were derived from ovarian stroma. Surface markers and differentiation ability were characterized. The effect of condition medium (CM) of OvMSC on the transformation of SKOV3 ovarian cancer cells was tested and the level and downstream signalings of IL6 were investigated. Results: OvMSC had a similar surface marker profiles as bone marrow mesenchymal stem cells, i.e. CD44 (+), CD90 (+) and CD45 (-) and was readily inducible to osteogenic, adipogenic and chondrogenic differentiations. Upon treatment CM of OvMSC, an increase of proliferation, colony formation and tumor sphere formation of SKOV3 cells was noted. The ELISA assay revealed CM of OvMSC had high level of IL-6, which readily activated JAK2 and STAT3 in the cancer cells. Adding of IL-6 blocking antibody to the CM of OvMSC significantly reduced the transformation activity to SKOV3 cells. Conclusion: IL-6 secreted by OvMSC may be an important transformation signal to the developing ovarian serous carcinoma, the JAK2/STAT3 signaling pathway. The study suggests the possible source of transforming IL-6 from OvMSC in the development of serous ovarian carcinoma. Citation Format: Dah-Ching Ding, Tang-Yuan Chu. Oovarian mesenchymal stem cells secreted Interleukin-6 promotes the malignant transformation of serous ovarian cancer. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr B60.
NOVEL ANTI-OXIDANT BIOMARKERS PREDICT ABLATION OUTCOME IN ATRIAL FIBRILLATION PATIENTS AGED 65-YEARS OR OLDER: RESULTS FROM A PROSPECTIVE PILOT STUDY (IMPACT)
Authors: Sanghamitra Mohanty, Prasant Mohanty, Luigi Di Biase, Chintan Trivedi, Rong Bai, Pasquale Santangeli, John Burkhardt, Rodney Horton, G. Gallinghouse, Javier Sanchez, Jason Zagrodzky, Shane Bailey, Andrea Natale
Journal: Journal of the American College of Cardiology (2014)
Malignancy in patients with sickle cell disease
Authors: William H. Schultz, Russell E. Ware
Journal: American Journal of Hematology (2003)

Abstract Malignancy in patients with sickle cell disease (SCD) has been previously reported, but the types of cancer and its incidence remain undefined. With the advent of hydroxyurea therapy, there is concern about increasing the cancer risk for patients with SCD. The International Association of Sickle Cell Nurses and Physician Assistants identified 52 cases of cancer (49 patients) among 16,613 patients with SCD followed at 52 institutions. The median age at malignancy diagnosis was 34 years (range, 14 months–62 years). Twenty‐one cases (40%) occurred in pediatric patients, primarily leukemia ( n = 7) or Wilms' tumor ( n = 5), with 15 children surviving. Most adults had solid tumors, especially carcinomas, and only nine were known to be alive. Three patients received hydroxyurea before the diagnosis of malignancy. These data provide essential baseline information for the accurate interpretation of future reports of malignancy in patients with SCD, especially those receiving hydroxyurea therapy. Am. J. Hematol. 74:249–253, 2003. © 2003 Wiley‐Liss, Inc.
THE PRINCIPLES OF VACCINE THERAPY.
Authors: ALMROTH E. WRIGHT
Journal: JAMA (1907)

<h3>CONDITIONS WHICH OBTAIN IN THE FOCI OF BACTERIAL INFECTION.</h3> We may conveniently begin with the study of the conditions which obtain in foci of bacterial infection. I have already pointed out that the foci in which bacteria cultivate themselves are in every case "foci of lowered bacteriotropic pressure," and that the deficit of antibacterial substances in such foci can be accounted for by the facts that bacteriotropic substances are absorbed whenever blood fluids come in contact with bacteria, and that in the case of foci which are cut off from the blood stream the conveyance of bacteriotropic substances to the focus of infection by the lymph stream can only rarely keep pace with the absorption. This premised with regard to the conditions which are common to all bacterial foci, I may conveniently direct attention to special conditions which obtain in infections of serous membranes where serous effusion has taken place,
Mature entrants to medicine
Authors: A. Woodall, M. Pickard
Journal: BMJ (1997)

Alan Woodall and Mark Pickard discuss education and career choices for medics who aren't just straight from the sixth form 

Almost 5% of British medical students are mature students, most of whom are graduates. These range from students entering immediately after a degree to those who have already pursued other careers. Compared with A level entrants, mature students in Britain have a lower dropout rate,1 better preclinical academic performance,2 and find it easier to communicate with patients in clinical years.3 According to Peter Richards, the former dean of St Mary's medical school, mature students “make a significant contribution to the stability and maturity of their immediate year and more widely in the medical school.”3 They often provide advice to younger students with problems who are reluctant to approach staff. In addition, some graduates with research backgrounds undertake research alongside their medical studies to the benefit of their school.

It is difficult to enter medicine as a mature student in Britain, as the majority of places are for A level entrants. Few applicants over the age of 30 are admitted, on the grounds that they have less time to serve the NHS. Similar arguments were once used to limit the entry of women. Some medical schools interview all mature entrants to assess their commitment, while offering A level entrants places solely from their UCAS form, and yet mature students often have a greater awareness of what constitutes a career in medicine.4 Today many people pursue multiple careers and use previous life experience to enhance their current profession. The current recruitment policy on mature students appears outdated and based on subjective cost-benefit “analysis.” Few …
Anisotropic Cellular Network Formation in Engineered Muscle Tissue through the Self‐Organization of Neurons and Endothelial Cells
Authors: Hironobu Takahashi, Tatsuya Shimizu, Masamichi Nakayama, Masayuki Yamato, Teruo Okano
Journal: Advanced Healthcare Materials (2014)

Tissue anisotropy directed by cell sheets: Aligned myoblasts can be harvested as an anisotropic cell sheet using a micropatterned thermoresponsive substrate. Neurons and endothelial cells sandwiched between multiple anisotropic cell sheets self-organize oriented cellular networks in the tissue construct. This simple tissue engineering technique is useful for the creation of biomimetic microstructures in complex tissue, required for future advances in regenerative medicine. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Venous hypertension of the hand caused by hemodialysis shunt: Immunofluorescence studies of pericapillary cuffs
Authors: Mirjam Brakman, William R. Faber, Jimmy E. Zeegelaar, Mente T. Bousema, Joop L. van Proosdij, Jo A.M. Kerckhaert
Journal: Journal of the American Academy of Dermatology (1994)
A Bayesian Compound Stochastic Process for Modeling Nonstationary and Nonhomogeneous Sequence Evolution
Authors: S. Blanquart
Journal: Molecular Biology and Evolution (2006)

Variations of nucleotidic composition affect phylogenetic inference conducted under stationary models of evolution. In particular, they may cause unrelated taxa sharing similar base composition to be grouped together in the resulting phylogeny. To address this problem, we developed a nonstationary and nonhomogeneous model accounting for compositional biases. Unlike previous nonstationary models, which are branchwise, that is, assume that base composition only changes at the nodes of the tree, in our model, the process of compositional drift is totally uncoupled from the speciation events. In addition, the total number of events of compositional drift distributed across the tree is directly inferred from the data. We implemented the method in a Bayesian framework, relying on Markov Chain Monte Carlo algorithms, and applied it to several nucleotidic data sets. In most cases, the stationarity assumption was rejected in favor of our nonstationary model. In addition, we show that our method is able to resolve a well-known artifact. By Bayes factor evaluation, we compared our model with 2 previously developed nonstationary models. We show that the coupling between speciations and compositional shifts inherent to branchwise models may lead to an overparameterization, resulting in a lesser fit. In some cases, this leads to incorrect conclusions, concerning the nature of the compositional biases. In contrast, our compound model more flexibly adapts its effective number of parameters to the data sets under investigation. Altogether, our results show that accounting for nonstationary sequence evolution may require more elaborate and more flexible models than those currently used.
Role of the renin-angiotensin system in blood pressure regulation. The cardiovascular effects of converting enzyme inhibition in normotensive subjects.
Authors: A P Niarchos, T G Pickering, D B Case, P Sullivan, J H Laragh
Journal: Circulation Research (1979)

The role of the renin-angiotensin system in the regulation of blood pressure in normal human subjects was investigated by administering to them the converting enzyme inhibitor (SQ 20881) during sodium-replete and sodium-depleted states.In the sodium-replete state (150 m£q sodium intake for 5 days) in eight normal subjects, converting enzyme inhibitor decreased the average mean arterial pressure from 75 ± 4 to 65 ± 5 mm Hg (P < 0.005) because of a decrease in peripheral resistance from 17 ± 1 to 14 ± 1 U (P < 0.025).Cardiac output did not change because of a simultaneous decrease in venous return.Sodium depletion (10 mEq sodium intake for 5 days) in six subjects resulted in an insignificant decrease in blood pressure (from 7 5 ± 4 t o 6 9 ± 2 mm Hg), whereas cardiac output decreased from 5.15 ± 0.29 to 3.91 ± 0.22 liters/min (P < 0.05).Plasma renin activity increased with sodium depletion from 2.13 ± 0.38 to 7.3 ± 1.3 ng/ml per hour (P< 0.005).Converting enzyme inhibitor administration in the sodium-depleted state (n » 8) decreased mean arterial pressure from 69 ± 2 to 53 ± 5 mm Hg (P < 0.005) because of a decrease in peripheral resistance from 18 ± 1 to 12 ± 1 U (P < 0.005), whereas cardiac output increased from 3.91 ± 0.33 to 4.40 ± 0.30 liters/min (P < 0.005).The maximum decrease in diastolic blood pressure caused by the inhibitor correlated to the control plasma renin activity (r = 0.76, P < 0.01, n =• 14 measurements).These results indicate that the renin-angiotensin system participates in the regulation of blood pressure and cardiac function in normal subjects, even in the sodium-replete state.This role of the renin-angiotensin system in cardiovascular homeostasis in normal subjects becomes more crucial during sodium depletion when plasma renin (angiotensin II) is markedly increased.Cux Res 45: 1979 RECENT studies (Laragh, 1978) have provided evidence supporting a possible role for the reninangiotensin system in the pathogenesis and maintenance of elevated arterial pressure in essential and renovascular hypertension in human subjects.This pathogenetic role of angiotensin II has been investigated more precisely because of the availability, initially, of the angiotensin II competitive antagonist, saralasin (P 113), and, more recently, of the inhibitors of the angiotensin-converting enzyme.These agents, unlike saralasin, have no intrinsic agonistic activity, since they act by blocking the conversion of angiotensin I to angiotensin II, thereby eliminating the cardiovascular and endocrine effects of circulating angiotensin II.However, the participation of the renin-angiotensin system in the regulation of arterial pressure in normal human subjects has not been characterized fully because so
I'm Running on Insulin: Summary of the history of the International Diabetic Athletes Association
Authors: Ulrike Thurm, Paula N Harper
Journal: Diabetes Care (1992)

The changes that physical activity brings in the functioning of the human body have a special interest to active individuals with diabetes. Certain adjustments in dosing are necessary. Even today, with such an emphasis on healthy life-style, little information is available to assist an individual with diabetes to exercise safely. Granted, no easy formula exists. Many different factors influence blood glucose. Most often, individuals with diabetes learn by trial and error how to best manage their favorite activity. In 1985, Paula Harper founded the International Diabetic Athletes Association (IDAA) in hopes of educating people with diabetes about the benefits of regular exercise. For most individuals with insulin-dependent (type I) diabetes mellitus, it is not encouragement, but safety that is the issue. The IDAA offers great opportunities for sharing ideas at its annual meetings. These meetings attract an exceptional faculty of speakers and offer a mix of workshops led by experienced diabetic athletes on various sports. A quarterly newsletter is published that presents new information and recognizes success stories. IDDA chapters exist in the U.S., Canada, U.K., Germany, France, Luxembourg, Switzerland, Belgium, the Netherlands, and Spain.
939-82 Efficacy of Gadolinium-BOPTA in Magnetic Resonance Imaging to Assess Acute Myocardial Infarction in Man
Authors: Eduard R. Holman, Albert C. van Rossum, Hubert W. Vliegen, Albert de Roos, Ton Doesburg, Ernst E. van der Wall
Journal: Journal of the American College of Cardiology (1995)
Reply to Rune Kvåle, Eivor Hernes and Freddie Bray's Letter to the Editor re: E. David Crawford, Per-Anders Abrahamsson. PSA-based Screening for Prostate Cancer: How Does It Compare with Other Cancer Screening Tests? Eur Urol 2008;54:262–73
Authors: E. David Crawford, Per-Anders Abrahamsson
Journal: European Urology (2008)
Keloids in Rubinstein–Taybi syndrome: a clinical study
Authors: A.L. Kar, G. Houge, A.C. Shaw, D. Jong, M.J. Belzen, D.J.M. Peters, R.C.M. Hennekam
Journal: British Journal of Dermatology (2014)

Journal Article Keloids in Rubinstein–Taybi syndrome: a clinical study Get access A.L. van de Kar, A.L. van de Kar Department of Plastic Surgery Academic Medical Center University of Amsterdam Amsterdam 1105 AZ The NetherlandsDepartment of Plastic Surgery Onze Lieve Vrouwe Gasthuis Amsterdam The Netherlands Search for other works by this author on: Oxford Academic Google Scholar G. Houge, G. Houge Center for Medical Genetics and Molecular Medicine Haukeland University Hospital Bergen Norway Search for other works by this author on: Oxford Academic Google Scholar A.C. Shaw, A.C. Shaw Department of Clinical Genetics Guy's and St Thomas' NHS Foundation Trust London U.K Search for other works by this author on: Oxford Academic Google Scholar D. de Jong, D. de Jong Department of Pathology Free University Medical Center Amsterdam The Netherlands Search for other works by this author on: Oxford Academic Google Scholar M.J. van Belzen, M.J. van Belzen Department of Clinical Genetics Leiden University Medical Center Leiden The Netherlands Search for other works by this author on: Oxford Academic Google Scholar D.J.M. Peters, D.J.M. Peters Department of Human Genetics Leiden University Medical Center Leiden The Netherlands Search for other works by this author on: Oxford Academic Google Scholar R.C.M. Hennekam R.C.M. Hennekam Departments of Pediatrics and Translational Genetics Academic Medical Center University of Amsterdam Amsterdam 1105 AZ The Netherlands Correspondence R.C.M. Hennekam. E‐mail: r.c.hennekam@amc.uva.nl Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 171, Issue 3, 1 September 2014, Pages 615–621, https://doi.org/10.1111/bjd.13124 Published: 01 September 2014
Induction of autophagic cell death of glioma-initiating cells by cell-penetrating d-isomer peptides consisting of Pas and the p53 C-terminus
Authors: Yutaka Ueda, Fan-Yan Wei, Taku-ichiro Hide, Hiroyuki Michiue, Kentaro Takayama, Taku Kaitsuka, Hideo Nakamura, Keishi Makino, Jun-ichi Kuratsu, Shiroh Futaki, Kazuhito Tomizawa
Journal: Biomaterials (2012)