tbuckley/cabot-search huggingface dataset:
Asthma and Nonsteroidal Anti-Inflammatory Drugs
Authors: A. SZCZEKLIK
Journal: Annals of Internal Medicine (1979)

Letters and Correction1 January 1979Asthma and Nonsteroidal Anti-Inflammatory DrugsA. SZCZEKLIK, M.D., R. J. GRYGLEWSKI, M.D., E. NIZANKOWSKA, M.D.A. SZCZEKLIK, M.D.Search for more papers by this author, R. J. GRYGLEWSKI, M.D.Search for more papers by this author, E. NIZANKOWSKA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-1-126 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We have recently studied (1) a 55-year-old patient suffering from bronchial asthma whose attacks were relieved by aspirin and whose case was in many respects similar to the interesting case recently reported by Kordansky and colleagues (2). In our patient the airway obstruction was strikingly relieved by aspirin and by three other cyclo-oxygenase inhibitors (indomethacin, mefenamate, and fenoprofen), but not by two other analgesics (salicylamide and benzydamine), which do not inhibit prostaglandin biosynthesis. We assumed, therefore, that pharmacologic removal of a product of arachidonic acid cyclo-oxygenation from the respiratory tract of our patient helped him to overcome...References1. SZCZEKLIK A, GRYGLEWSKI R, and NIZANKOWSKA E: Asthma relieved by aspirin and by other cyclo-oxygenase inhibitors. Thorax, in press Google Scholar2. KORDANSKY D, ADKINSON N, NORMAN P, and ROSENTHAL R: Asthma improved by nonsteroidal anti-inflammatory drugs. Ann Intern Med 88:508-511, 1978 LinkGoogle Scholar3. GRYGLEWSKI R: Screening for inhibitors of prostaglandin and thromboxane biosynthesis, in Prostaglandins and Thromboxanes, edited by BERTI F, SAMUELSSON B, VELO GP. New York and London, Plenum Press, 1977, pp. 85-109 CrossrefGoogle Scholar4. SZCZEKLIK A, GRYGLEWSKI R, and CZERNIAWSKA-MYSIK G: Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks to aspirin sensitive asthma. Br Med J 1:67-69, 1975 CrossrefMedlineGoogle Scholar5. SZCZEKLIK A, GRYGLEWSKI R, and CZERNIAWSKA-MYSIK G: Clinical patterns of hypersensitivity to nonsteroidal anti-inflammatory drugs and their pathogenesis. J Allergy Clin Immunol 60:276 1977 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: A. SZCZEKLIK, M.D.; R. J. GRYGLEWSKI, M.D.; E. NIZANKOWSKA, M.D.Affiliations: Institute of Internal Medicine and Department of Pharmacology Copernicus Academy of Medicine Skawińska 8, 31-066 Kraków Poland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnalgesics and Nonsteroidal Anti-Inflammatory Drugs 1 January 1979Volume 90, Issue 1Page: 126-127KeywordsAnalgesicsAspirinAsthmaBiosynthesisDrugsProstaglandinRespiratory system ePublished: 1 December 2008 Issue Published: 1 January 1979 PDF downloadLoading ...
Iron deficiency in adolescents.
Authors: D. Lyons, G. Kavanagh, J. Fielding
Journal: BMJ (1989)

many forms of non-accidental injury may do this either directly by the injury itself or by indirect means, the same result can occur from other conditions.These are most commonly epileptic fits, but haemorrhages can also occur in asphyxia and thoracic compression, especially if there are associated blood coagulation defects.While retinal haemorrhages may well be an associated sign of non-accidental injury, they should not be taken as being pathognomonic ofthis cause.
Can the use of radiography of arms and legs in accident and emergency units be made more efficient?
Authors: M C Charny, W P Ennis, C J Roberts, K T Evans
Journal: BMJ (1987)

The efficiency of the selection of patients with injured arms and legs for radiography was investigated. The analysis was based on data on presenting signs and symptoms collected in a multicentre study organised by the Royal College of Radiologists working party on the effective use of diagnostic radiology. The work was carried out in eight accident and emergency units in England and Wales. With the help of various computer simulation techniques a combination of signs and symptoms that might usefully improve present practice was sought. The results suggest that for injuries of arms and legs the clinical determinants of bony injury cannot be refined further to improve current selection for radiography. This study shows that existing clinical practice is probably as good as it can be.
Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease.
Authors: G Hellers, O Bergstrand, S Ewerth, B Holmstrom
Journal: Gut (1980)

During the period 1955 to 1974 inclusive, 826 patients developed Crohn's disease and were registered citizens of Stockholm County at the time of definite diagnosis. These patients were followed up and investigated with reference to the occurrence of and outcome after treatment for anal fistulae. These fistulae were recorded in 184 patients (23%). The incidence of anal fistulae increased the further distally the intestinal lesion was located. Healing followed local operation for anal fistula before curative intestinal resection in approximately 60% of the patients with small intestinal and combined ileocolic disease. However, patients with colonic Crohn's disease did not heal after such treatment. When curative intestinal resection was the primary procedure, 47% of the patients healed spontaneously. Small intestinal and combined ileocolic disease was associated with a good prognosis--90% were healed at follow-up, while patients with colonic disease had a poor prognosis. The combination of rectal Crohn's disease and anal fistula invariably led to proctocolectomy.
Cardiovascular Dynamics in Complete Heart Block at Various Heart Rates
Authors: ALBERTO BENCHIMOL, YEOU-BING LI, E. GREY DIMOND
Journal: Circulation (1964)

THE purpose of this report is to describe the cardiovascular dynamics in patients with complete heart block at various rates and the effect of exercise at a fixed heart rate, to ascertain the contributions of stroke volume and of heart rate in the regulation of cardiac output. Materials and MethodsThirteen patients with complete atrioventricu- lar block resulting from coronary disease were studied.In seven the diagnosis of coronary dis- ease was established by the presence of typical history and electrocardiographic and enzymatic findings compatible with an acute infarction.Of the remaining six cases, three had a typical his- tory of angina pectoris.In three cases there was no history of myocardial infarction or angina pectoris, and the diagnosis of coronary disease was suspected by the appearance of heart block above age 60 in the absence of any other possible etiologic factor that might be responsible for the establishment of the block.Exercise studies were performed in eight cases.Right heart catheterization was performed un- der local anesthesia prior to implantation of a permanent cardiac pacemaker.A no.-6 bipolar electrode catheter * 1 was introduced into the antecubital vein and advanced to the apex of the right ventricle.Another no.-7 Lehman cathe- ter was introduced into the cephalic vein and advanced to the right atrium and right ventricle.Cardiac output was determined by the indicator-dilution technic with indocyanine t (Cardio-
Vascular Mechanisms Pertaining to the Intrinsic Regulation of the Cerebral Circulation
Authors: GEORGE I. MCHEDISHVILI
Journal: Circulation (1964)

A review is given of recent work on the vascular mechanisms that participate in the intrinsic control of the cerebral circulation. The main emphasis is given to studies carried out at the Department of Pathophysiology, Institute of Physiology of the Georgian Academy of Sciences in Tbilisi (USSR). Physiologic as well as pathophysiologic mechanisms are considered. Emphasis is given to the important role of the large arteries carrying blood to the brain—the internal carotid and the vertebral arteries (major arteries of the brain)—in the regulation of cerebral circulation. These vessels differ in several respects from the smaller cerebral (pial) arteries in their functional and vasomotor behavior. The pial arteries have mainly a "nutritive" role as demonstrated during, for example, changing demands of blood supply for the cerebral tissue. Some recent data are presented that stress the important role played by the vasomotor innervation and by humoral factors for different parts of the cerebral vascular system during normal and pathologic events. A survey is also given of mechanisms pertaining to the cerebral venous system in the various compensatory vascular reactions during pathologic states of the brain.
Substandard care at "dysfunctional" Morecambe Bay maternity unit led to unnecessary deaths
Authors: J. Wise
Journal: BMJ (2015)

The maternity unit at Furness General Hospital in Cumbria was “seriously dysfunctional,” and failures of clinical care led to the unnecessary deaths of mothers and babies, an independent investigation has concluded.1

The investigation, led by Bill Kirkup, a former associate chief medical officer and regional director of public health who previously led investigations into the Oxford paediatric cardiac surgery unit and Jimmy Savile’s involvement with Broadmoor Hospital, detailed 20 instances of significant failures of care in the maternity unit run by the University Hospitals of Morecambe Bay NHS Foundation Trust. These failures may have contributed to the deaths of three mothers and 16 babies between 2004 and 2013. The prevalence of serious failures of care was four times that at the trust’s other main maternity unit, the Royal Lancaster Infirmary. Different clinical care in these cases would have been expected to prevent the death …
Reconfiguring Child Health Services in the Inner City
Authors: David Wood
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Molecular basis for the deficiency of complement 1 inhibitor in type I hereditary angioneurotic edema.
Authors: M Cicardi, T Igarashi, F S Rosen, A E Davis
Journal: Journal of Clinical Investigation (1987)

Hereditary angioneurotic edema (HANE) results from deficiency of complement 1 inhibitor (C1 INH). In type I HANE, C1 INH is present in serum at levels 5-30% of normals. Using cultured monocytes and biosynthetic labeling of proteins, C1 INH was detected in supernatants of cells from HANE patients at levels 20% of those detected in normals. The intracellular reduction of C1 INH in patients' monocytes approached 50%. The study of C1 INH messenger RNA (mRNA) by Northern blot analysis indicated that in HANE patients' monocytes a message of normal size is present at about half the concentration of that from normal cells. One of the patients analyzed showed the presence of a genetically inherited abnormal mRNA (1.9 kb) in addition to the normal mRNA (2.1 kb). Southern blot analysis of DNA from peripheral blood leukocytes did not show any difference in quantity or in sizes of endonuclease restriction fragments between patients and normals. The defect(s), therefore, in type I HANE is pretranslational, but is not due to a deletion or to a major chromosomal rearrangement.
Bile acid clearance in liver disease.
Authors: L K Luey, K W Heaton
Journal: Gut (1979)

The disappearance of intravenously administered cholylglycine-14C was studied in the fasting and postprandial states in seven subjects with healthy livers and 10 patients with liver disease. In neither group was there any significant difference in the pattern of 14C disappearance. In another 10 patients with liver disease there was no significant change when a loading dose of cholylglycine was given orally two hours beforehand. Clearance of bile acids seems to be unimpaired in all except severe liver disease. The apparent deterioration in endogenous bile acid removal after meals may be due simply to the increased amount of bile acids which are in circulation and available for portosystemic shunting.
Is There a Causal Association between Genotoxicity and the Imposex Effect?
Authors: Josephine A. Hagger, Michael H. Depledge, Jörg Oehlmann, Susan Jobling, Tamara S. Galloway
Journal: Environmental Health Perspectives (2005)

There is a growing body of evidence that indicates common environmental pollutants are capable of disrupting reproductive and developmental processes by interfering with the actions of endogenous hormones. Many reports of endocrine disruption describe changes in the normal development of organs and tissues that are consistent with genetic damage, and recent studies confirm that many chemicals classified to have hormone-modulating effects also possess carcinogenic and mutagenic potential. To date, however, there have been no conclusive examples linking genetic damage with perturbation of endocrine function and adverse effects in vivo. Here, we provide the first evidence of DNA damage associated with the development of imposex (the masculinization of female gastropods considered to be the result of alterations to endocrine-mediated pathways) in the dog-whelk Nucella lapillus. Animals (n = 257) that displayed various stages of tributyltin (TBT)-induced imposex were collected from sites in southwest England, and their imposex status was determined by physical examination. Linear regression analysis revealed a very strong relationship (correlation coefficient of 0.935, p < 0.0001) between the degree of imposex and the extent of DNA damage (micronucleus formation) in hemocytes. Moreover, histological examination of a larger number of dog-whelks collected from sites throughout Europe confirmed the presence of hyperplastic growths, primarily on the vas deferens and penis in both TBT-exposed male snails and in females that exhibited imposex. A strong association was found between TBT body burden and the prevalence of abnormal growths, thereby providing compelling evidence to support the hypothesis that environmental chemicals that affect reproductive processes do so partly through DNA damage pathways.
Functional compartmentation of glycolytic versus oxidative metabolism in isolated rabbit heart.
Authors: J Weiss, B Hiltbrand
Journal: Journal of Clinical Investigation (1985)

To investigate whether energy derived from glycolytic and oxidative metabolism are preferentially used for different functions in heart, tension, intracellular potential, and extracellular [K+] and pH (using triple barrel K/pH electrodes, tip diameter 0.5 mm) were monitored in isolated arterially perfused rabbit interventricular septa during exposure to hypoxia and metabolic inhibitors. Myocardial content of high energy phosphates, lactate, and glycogen were determined under the same conditions. Inhibiting oxidative metabolism with hypoxia, dinitrophenol (10(-5)M), or Na-azide (10(-3)M) caused marked suppression of tension (by 73 +/- 5, 65 +/- 8, and 50 +/- 14%, respectively) and a small increase in [K+]0 (0.8 +/- 0.4, 0.5 +/- 0.25, and 0.4 +/- 0.2 mM, respectively) after 10 min. Inhibiting glycolysis with iodoacetate (IAA) (10(-3)M) had a much smaller suppressant effect on tension (28 +/- 24%) but markedly increased [K+]0 accumulation (by 1.8 +/- 1.1 mM) at 10 min. These differences, when IAA was compared individually to the other interventions, were highly significant. The shortening of action potential duration was not significantly different for the four interventions. pH0 increased slightly during IAA (+0.04-+0.06 U) and fell during the other interventions (-0.10--0.16 U), but this did not account for the differences in [K+]0 accumulation and tension between inhibition of glycolytic vs. oxidative metabolism. Except for hypoxia, total cellular content of high energy phosphates was not significantly depressed under the various conditions. This data suggests that energy from glycolysis is preferentially used to support sarcolemmal function (as manifested by K+ loss), whereas oxidatively derived energy preferentially supports contractile function. Indexing terms: cardiac metabolism, extracellular pH, metabolic inhibitors, hypoxia, extracellular K+ accumulation, and glycolysis.
Inhibition of proteasome function leads to NF-κB-independent IL-8 expression in human hepatocytes
Authors: Swati Joshi-Barve, Shirish S. Barve, Waseem Butt, Jon Klein, Craig J. McClain
Journal: Hepatology (2003)

Breakdown of cellular proteins is a highly regulated process, and the ubiquitin–proteasome pathway is the major proteolytic system in the cell. It regulates the levels of numerous proteins that control gene expression and cell division, as well as responses to stress and inflammation. Recent studies have reported abnormalities in proteasome function in alcoholic liver disease (ALD). Moreover, a direct relation has been reported between impaired proteasome function and oxidative stress in experimental models of ALD. Neutrophil infiltration is a hallmark of ALD, and activated neutrophils are thought to play a role in the pathology of ALD. As a potent neutrophil chemoattractant and activator, interleukin 8 (IL–8) likely plays a key mechanistic role in many forms of liver injury. In this study, we evaluated the effects of inhibition of proteasome function on expression and release of IL–8 by human fetal hepatocytes and hepatoma cells. Our data demonstrate that inhibition of proteasome function in hepatocytes leads to apoptotic cell death. Decreased hepatocyte survival coincides with enhanced expression of IL–8, both at the protein and the messenger RNA (mRNA) levels. This increase in IL–8 is independent of nuclear factor κB (NF–κB) activation and is associated with an increase in c–Jun N–terminal kinase (JNK) and activator protein–1 (AP–1) activity. In conclusion, hepatocytes dying because of inhibition of proteasome function produce massive quantities of the proinflammatory chemokine IL–8, possibly resulting in neutrophil infiltration, increased inflammation, and liver injury.
Sleep in the surgical intensive care unit: continuous polygraphic recording of sleep in nine patients receiving postoperative care.
Authors: J Aurell, D Elmqvist
Journal: BMJ (1985)

Sleep was studied in nine patients for two to four days after major non-cardiac surgery by continuous polygraphic recording of electroencephalogram, electrooculogram, and electromyogram. Presumed optimal conditions for sleep were provided by a concerted effort by staff to offer constant pain relief and reduce environmental disturbance to a minimum. All patients were severely deprived of sleep compared with normal. The mean cumulative sleep time (stage 1 excluded) for the first two nights, daytime sleep included, was less than two hours a night. Stages 3 and 4 and rapid eye movement sleep were severely or completely suppressed. The sustained wakefulness could be attributed to pain and environmental disturbance to only minor degree. Sleep time as estimated by nursing staff was often grossly misjudged and consistently overestimated when compared with the parallel polygraphic recording. The grossly abnormal sleep pattern observed in these patients may suggest some fundamental disarrangement of the sleep-wake regulating mechanism.
Three-Year Follow-Up of Women With the Sole Diagnosis of Depressive Personality Disorder: Subsequent Development of Dysthymia and Major Depression
Authors: Jun Soo Kwon, Young-Me Kim, Chang-Gok Chang, Byung-Joo Park, Leen Kim, Doh Joon Yoon, Woo-Sang Han, Hoon-Jin Lee, In Kyoon Lyoo
Journal: American Journal of Psychiatry (2000)

The authors sought to determine whether subjects with the sole diagnosis of depressive personality disorder are at higher risk for developing dysthymia and major depression than are healthy comparison subjects.Eighty-five women with depressive personality disorder who had no comorbid axis I or axis II disorders and 85 age-matched healthy comparison women were initially recruited and reinterviewed 3 years later to evaluate the cumulative incidence rate of dysthymia and major depression.At the 3-year follow-up assessment, the women with depressive personality disorder had a significantly greater odds ratio for developing dysthymia than did the healthy comparison women. The difference in odds ratios for the development of major depression between women with and without depressive personality disorder did not reach statistical significance.The present study, the first to determine the subsequent development of dysthymia and major depression in subjects with the sole diagnosis of depressive personality disorder, found that subjects with depressive personality disorder had a greater risk of developing dysthymia than did healthy comparison subjects at 3-year follow-up. Findings of the current study also suggest that depressive personality disorder may mediate the effects of a family history of axis I unipolar mood disorders.
Abstract 5337: Laminin alpha 2 enables glioblastoma stem cell growth
Authors: Meizhang LI
Journal: Cancer Research (2012)

Abstract Glioblastomas (GBMs) are lethal cancers that display a cellular hierarchy parallel to the normal brain and are resistant to conventional therapies. It has been suggested that interaction between GSCs and their adjacent perivascular niche plays the critical roles to maintain their malignancy and self-renewal. Extracellular matrix (ECM) cues instruct stem cell behavior in many niches and the objective of our study was to elucidate its composition and contribution to GSC maintenance in the perivascular niche. We utilized human tumor tissue for immunofluorescence analysis and derived GSC for subsequent functional studies from tumor tissues. We find that laminin family of ECM proteins are located in the perivascular GBM niche and are negative prognostic indicators of patient survival. To identify the source of laminins, we characterized cellular elements within the niche and found that key laminins were expressed by non-stem tumor cells and tumor-derived endothelial cells (ECs). Targeting the laminin alpha 2 chain by RNA interference inhibited GSC growth and self-renewal. In co-culture studies of GSCs and non-stem tumor cells, laminin alpha 2 knockdown in non-stem tumor cells resulted in decreased GSC growth. These findings indicate that growth/proliferation of GSCs depends on the direct connection between extrinsic laminin alpha 2 and environmental matrix. Our studies highlight the contribution of non-stem tumor cell-derived laminin juxtracrine signaling. As laminin alpha 2 has recently been identified as a molecular marker of aggressive ependymoma, we propose that the brain vascular ECM promotes tumor malignancy through maintenance of the GSC compartment providing not only a molecular fingerprint but also a possible therapeutic target. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5337. doi:1538-7445.AM2012-5337