tbuckley/cabot-search huggingface dataset:
Behavioral Medicine in Primary Care-A Practical Guide
Authors: David A. Horowitz
Journal: Annals of Internal Medicine (1998)

Medical Writings1 March 1998Behavioral Medicine in Primary Care-A Practical GuideDavid A. Horowitz, MDDavid A. Horowitz, MDUniversity of Pennsylvania School of Medicine, Philadelphia, PennsylvaniaSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-128-5-199803010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Feldman ND, Christensen JF; eds. 345 pages. Stamford, CT: Appleton & Lange; 1997. $31.95. ISBN 0838506364. Order phone 800-423-1359.Field of medicine: Behavioral medicine.Format: Softcover book.Audience: Clinicians practicing and teaching in primary care specialties and trainees in these specialties.Purpose: To discuss a wide range of psychosocial issues and problems facing the primary care physician and to suggest practical approaches to possible solutions.Content: The text is divided into five sections that center on various aspects of the physician–patient-family relationship. The book begins with an examination of this relationship, which emphasizes physician insight and sensitivity. This is followed ... Author, Article, and Disclosure InformationAffiliations: University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1998Volume 128, Issue 5Page: 415KeywordsComputed axial tomographyHIVHeart diseasesObesityPrimary care physiciansPulmonary diseasesPulmonary hypertensionRacial and ethnic issuesSmoking cessationValvular diseases ePublished: 15 August 2000 Issue Published: 1 March 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effect of starch and sucrose on carbohydrate-induced hyperlipaemia.
Authors: A. M. Cohen, N. A. Kaufmann, R. Poznanski, S. H. Blondheim, Y. Stein
Journal: BMJ (1966)

Medical Memoranda BEDICBJUNAL 339 drop in systemic arterial pressure from 170/80 to 70/45 mm.Hg, recorded from a cannula in the brachial artery.The pulse rose from 54 to 78/min.When he lay down again all the parameters returned to normal, but once more the arterial pressure lagged behind right atrial pressure.Similar haemodynamic changes occurred with a tilt-table, and in no instance did alteration in posture induce any symptoms.A convenient method of simulating the effects of postural change is to apply suction to the lower half of the body as described by Ardill et al. (1965).When a pressure of 44 mm.Hg below atmo- spheric was applied to this patient's body distal to the iliac crests, the systolic pressure fell to 55 mm.Hg, though no symptoms occurred.His circulatory adjustments to this manceuvre will be reported in detail elsewhere (Bannister, Ardill, and Fentem, in preparation).Exercise.-Theresponse to exertion was studied by asking the patient to climb up and down a step at a rate equivalent to 500 kg.-m./min.for three minutes.When he rested his arterial pres- sure dropped from 90/40 to 45/25 mm.Hg.Right atrial pressure fell 12 mm.Hg, but the pulse showed little change.Within 10 seconds of stopping exercise the patient complained of the visual disturbance which had brought him to hospital.He was unsteady, but he did not lose consciousness.His symptoms cleared on lying down.Valsalva's Manceuvre.-Thisshowed complete block of the vasomotor reflexes.
Extrahepatic manifestations of hepatitis C among United States male veterans
Authors: H El-Serag
Journal: Hepatology (2002)

Hepatitis C virus (HCV) has been associated with several extrahepatic conditions. To date, most studies assessing these associations involved small numbers of patients and lacked a control group. Using the computerized databases of the Department of Veterans Affairs, we carried out a hospital-based case-control study that examined all cases of HCV-infected patients hospitalized during 1992 to 1999 (n = 34,204) and randomly chosen control subjects without HCV (n = 136,816) matched with cases on the year of admission. The inpatient and outpatient files were searched for several disorders involving the skin (porphyria cutanea tarda [PCT], vitiligo, and lichen planus); renal (membranous glomerulonephritis [GN] and membranoproliferative glomerulonephritis); hematologic (cryoglobulin, Hodgkin's and non-Hodgkin's lymphoma [NHL]); endocrine (diabetes, thyroiditis); and rheumatologic (Sjögren's syndrome). The association between HCV and these disorders was examined in multivariate analyses that controlled for age, gender, ethnicity, and period of military service. Patients in the case group were younger in age (45 vs. 57 years), were more frequently nonwhite (39.6% vs. 26.3%), and were more frequently male (98.1% vs. 97.0%). A significantly greater proportion of HCV-infected patients had PCT, vitiligo, lichen planus, and cryoglobulinemia. There was a greater prevalence of membranoproliferative GN among patients with HCV but not membranous GN. There was no significant difference in the prevalence of thyroiditis, Sjögren's syndrome, or Hodgkin's or NHL. However, NHL became significant after age adjustment. Diabetes was more prevalent in controls than cases, but no statistically significant association was found after adjustment for age. In conclusion, we found a significant association between HCV infection and PCT, lichen planus, vitiligo, cryoglobulinemia, membranoproliferative GN, and NHL. Patients presenting with these disorders should be tested for HCV infection.
The Intervertebral Disc
Authors: Reginald R. Cooper
Journal: JAMA (1971)

Those interested in the human spine and its afflictions always welcome summaries of our present knowledge. In the initial chapters of this book, the authors lucidly summarize spine embryology, anatomy, and mechanics. An outline of pathology, biochemistry, and metabolic alterations during various stages of degenerative disk disease provides basic information which is integrated with clinical disorders of the spine. This correlation provides for disk disease a unified concept which derives partly from scientific data and, by necessity, partly from empirical observations. Excellent roentgenograms, drawings, and photographs complement the text.  Clinical manifestations of cervical syndromes are adequately portrayed. Many would restrict operative indications more than do the authors, especially in patients with residual symptoms after a hyperextension injury.  Two chapters on clinical features of lumbar disk disease clearly describe various syndromes and explain their pathologic significance. Some repetition in these adjacent sections indicates that the two might well be combined.  Extending
JMF2-1, a lidocaine derivative acting on airways spasm and lung allergic inflammation in rats
Authors: Jorge Carlos Santos da Costa, Priscilla Christina Olsen, Rodrigo de Azeredo Siqueira, Vinícius de Frias Carvalho, Magda Fraguas Serra, Luiz Anastácio Alves, Robson Xavier Faria, Debora Gonçalves Xisto, Patricia Rieken Macêdo Rocco, Renato Sérgio Balão Cordeiro, Patrícia Machado Rodrigues e Silva, Marco Aurélio Martins
Journal: Journal of Allergy and Clinical Immunology (2007)
A New Surgical Drain
Authors: Leonard H. Flax
Journal: JAMA (1961)

SURGICAL DRAINS have passed through many modifications and improvements since the days of Hippocrates when they were first introduced in the treatment of empyema. In 1890, Charles Bingham Penrose introduced the now famous Penrose drain. Through the years, certain basic principles of drain management have been formulated, but need for continual improvement in drain management remains with us. We accept surgical instruments and supplies as standard items, giving little thought to the possibility of improvement and the manner in which improvement might be accomplished. The various types of drains in use today do not provide adequate security against loss. A drain may disappear into a wound or be broken off during removal. For the surgeon, there persists that perplexing postoperative question: Where is the drain? An error in judgment may result in the leaving of a drain within a surgical wound. The surgeon's prime concern is to be sure
Treatment of Hypercholesterolemia
Authors: H. Richard Casdorph
Journal: JAMA (1967)

<h3>To the Editor:—</h3> I wish to congratulate you for the editorial "Preventive Therapy for Atherosclerosis" (<b>199</b>:578, 1967), which effectively and succinctly presented the concept that hypercholesterolemia should be treated, that more attention should be given to preventive therapy for atherosclerosis, and that the judicious use of drugs that lower the serum cholesterol level might be expected to aid in this regard. Since you only mentioned one drug which might be used for this purpose, I should like to add two others. The old standby, niacin (nicotinic acid), which has now been used for a decade or more, still probably has a place, providing the physician is aware of the side-effects which occasionally occur with its use and will take the necessary safeguards. Also, the patient must be willing to tolerate the flushing and itching which are part of the normal effect of niacin. Another drug, which we feel may
Continuous ambulatory peritoneal dialysis and renal transplantation: a five year experience.
Authors: P K Donnelly, T W Lennard, G Proud, R M Taylor, R Henderson, K Fletcher, W Elliott, M K Ward, R Wilkinson
Journal: BMJ (1985)

Continuous ambulatory peritoneal dialysis is a new and increasingly popular method of routine dialysis, but its effect on renal transplantation is uncertain. A non-randomised comparison was made of the outcome of grafting in patients who had been treated before transplantation with continuous ambulatory peritoneal dialysis with that in patients treated with haemodialysis. During the five years, 1979-84, after continuous ambulatory peritoneal dialysis was introduced to Newcastle upon Tyne 220 patients have received transplants after either continuous ambulatory peritoneal dialysis (61 patients) or haemodialysis (159 patients). During follow up no significant differences occurred in survival of patients or grafts between the two treatment groups. One year after transplantation the percentages of survivors who had received continuous ambulatory peritoneal dialysis and haemodialysis were 88% and 91% respectively, and overall graft survival was 66% and 72%, respectively. A multiple regression model was used to allow for differences among patients--for example, duration of dialysis and number of preoperative transfusions--on the survival of grafts. When only first cadaver grafts were considered (in 152 patients) graft survival (non-immunological failures excluded) was not significantly different between the patients treated with continuous ambulatory peritoneal dialysis and haemodialysis. Continuous ambulatory peritoneal dialysis is not a risk factor in renal transplantation, and its continued use in treatment of potential renal graft recipients is recommended.
Effect of the prostaglandin precursor, arachidonic acid, on histamine stimulated gastric secretion in the conscious dog, and observations on the effect of inhibiting endogenous prostaglandin synthesis.
Authors: M E Conolly, P R Bieck, N A Payne, B Adkins, J A Oates
Journal: Gut (1977)

A middle aged patient with multiple myeloma resulting in numerous pathological fractures underwent an L2, L3, and L5 vertebral cement augmentation for pain relief. After injection, the trocar at L2, the final level, could not be withdrawn despite several attempts of needle rotation, a second needle inserted to distract on, and rocking the needle on the pedicle. After a neurosurgical consultation, the patient was transferred to the operating room for open removal. As the needle protruded approximately 3 inches from the patient9s back, the patient could not be positioned supine, and was anesthetized and intubated in the right semi-prone position prior to being placed prone on the operating room table. The needle was surgically exposed, cut off at the pedicular bone edge, and its free component was removed.
Elevated Serum IP-10 Levels Observed in Type 1 Diabetes
Authors: Akira Shimada, Jiro Morimoto, Keiichi Kodama, Ryuji Suzuki, Yoichi Oikawa, Osamu Funae, Akira Kasuga, Takao Saruta, Shosaku Narumi
Journal: Diabetes Care (2001)

Although most patients with type 1 diabetes are considered to have T-cell-mediated autoimmune disease, a method of measuring of pancreatic beta-cell-specific T-cell function in cases of type 1 diabetes has yet to be established. Here, we focused on interferon-inducible protein-10 (IP-10), a chemokine that promotes the migration of activated T-helper 1 (Th1) cells and measured serum IP-10 levels in patients with human type 1 diabetes, which is regarded as a Th1-mediated disease.Serum samples were obtained from diabetic patients, and the levels of autoantibodies (GAD and insulinoma-associated protein-2 [IA-2]) and IP-10 were measured. Diabetic patients positive for either or both of the autoantibodies were classified as Ab+ type 1, and those negative for both were classified as Ab type 1. To evaluate islet antigen-specific responses, peripheral blood from patients stimulated with or without GAD was used, and intracellular cytokine staining for flowcytometry was performed.The Ab+ and Ab- type 1 groups both showed a significantly higher serum IP-10 level than the healthy subjects (P < 0.001 and P < 0.05, respectively), and the IP-10 level in the recent-onset Ab+ subgroup was significantly higher than that in the established (longstanding) Ab+ subgroup (P < 0.002). Furthermore, there was a significant positive correlation between the serum IP-10 level and the number of GAD-reactive gamma-interferon-producing CD4+ cells in the Ab+ type 1 group (P < 0.007).Our findings demonstrate that measurement of serum IP-10 concentrations is useful in patients with type 1 diabetes.
U7 snRNAs: A Computational Survey
Authors: Manja Marz, Axel Mosig, Bärbel M.R. Stadler, Peter F. Stadler
Journal: Genomics Proteomics & Bioinformatics (2007)

Abstract U7 small nuclear RNA (snRNA) sequences have been described only for a handful of animal species in the past. Here we describe a computational search for functional U7 snRNA genes throughout vertebrates including the upstream sequence elements characteristic for snRNAs transcribed by polymerase II. Based on the results of this search, we discuss the high variability of U7 snRNAs in both sequence and structure, and report on an attempt to find U7 snRNA sequences in basal deuterostomes and non-drosophilids insect genomes based on a combination of sequence, structure, and promoter features. Due to the extremely short sequence and the high variability in both sequence and structure, no unambiguous candidates were found. These results cast doubt on putative U7 homologs in even more distant organisms that are reported in the most recent release of the Rfam database.
Prophylactic impact of imatinib administration after allogeneic stem cell transplantation on the incidence and severity of chronic graft versus host disease in patients with Philadelphia chromosome-positive leukemia
Authors: H Nakasone, Y Kanda, H Takasaki, C Nakaseko, T Sakura, S Fujisawa, A Yokota, S Yano, K Usuki, A Maruta, D Abe, T Hoshino, S Takahashi, H Kanamori, S Okamoto
Journal: Leukemia (2010)
Masks of Deception
Authors: Samuel Vaisrub
Journal: JAMA (1980)

Elsewhere in this issue (p 1239), Alexander deplores the attitudes of some physicians to the deceptive practices of their patients. He is particularly concerned with the acquiescence of physicians to exaggeration or falsification of symptoms in compensation cases or in any other setting in which a third party, be it the government or an insurance company, foots the bill. The tacit acceptance of such practices, whether motivated by reluctance to antagonize a faithful patient, by sympathy with the individual vis-à-vis the "establishment," or by desire to keep out of trouble, involves the physician in a situation that smacks of unsavory complicity. Less clearly defined is the possible physician complicity in deceptions other than courtroom malingering. Such deceptions may not always be recognized, and, if recognized, they are not generally acknowledged as such. In a recent exposé, Naish<sup>1</sup>classifies as deceivers those patients who are usually regarded as psychoneurotics or
The Value of Clinical Judgment in the Detection of Clinical Deterioration
Authors: Amitkumar R. Patel, Frank J. Zadravecz, Robert S. Young, Mark V. Williams, Matthew M. Churpek, Dana P. Edelson
Journal: JAMA Internal Medicine (2015)

not capture outcomes of patients who may have been considered for, but did not undergo, coronary revascularization and do not know if overall cardiovascular outcomes in these patients has changed.In conclusion, we found that rates of coronary revascularization have declined by nearly 40% in Massachusetts since 2003, with the most rapid declines in elective PCI procedures and isolated CABGs.These data have broad implications for regional health policy, training and provider accreditation, hospital resource allocation, and patient outcomes.
Restenosis after intracoronary ultrasound-guided stent deployment; a randomized multicentric study, results on the 6 month angiographic restenosis rate
Authors: F. Schiele, N. Maneveau, A. Vuillemenot, D.D. Zhang, C. Xu, S. Gupta, J.-P. Bassand
Journal: Journal of the American College of Cardiology (1998)
Abstract 2528: Enhanced sensitivity of pancreatic cancer cells to the concurrent inhibition of aberrant Stat3 and EGFR or Src
Authors: Jaganathan Soumya, Pei Bin Yue, James Turkson
Journal: Cancer Research (2010)

Abstract Pancreatic cancer is a lethal disease with little understanding of the etiology and no effective therapies. While aberrant epidermal growth factor receptor (EGFR), Src and Stat3 are detected in pancreatic cancer and implicated in the disease, their exact roles in the support of the disease phenotype remain poorly defined. Moreover, the potential for a cross-talk between EGFR, Src and Stat3 poses a challenge to any therapy that targets only one of these entities. In this study, we sought to define the EGFR, Src and Stat3 signaling integration and to investigate the contributory roles of the three entities to the pancreatic cancer phenotype. We found in Panc-1 and Colo-357 lines that phospho-Y845EGFR, pY1068EGFR and pY1086EGFR levels are responsive to c-Src inhibition, in contrast to pY1173EGFR that is solely EGFR kinase-dependent. Treatment of Panc-1 and Colo-357 cells with the EGFR inhibitor, Iressa (ZD 1839) or the Src inhibitor, Dasatinib (Das) suppressed the constitutively-active Stat3 activity, suggesting that both EGFR and Src activities promote aberrant Stat3 activation in pancreatic cancer cells. However, the early suppression of aberrantly-active Stat3 by the EGFR and Src inhibition in Panc-1 cells is countered by a Janus kinase (Jaks)-dependent re-activation, suggesting that Jaks activity could represent a compensatory mechanism for Stat3 induction. The abrogation of c-Src activity by either Das treatment or the over-expression of a kinase-dead c-Src mutant suppressed the levels of phospho-FAK, phospho-p130Cas, phospho-cortactin, phospho-p120catenin, and phospho-paxillin, suggesting that Src activity induces the mediators of motility and migration in pancreatic cancer cells. By contrast, neither EGFR nor Src inhibition modulated the baseline enhanced phospho-ErkMAPK or phospho-Akt levels in Panc-1 and Colo-357 cells, consistent with the observation that the inhibition of EGFR or Src alone only weakly suppressed cell growth and survival of pancreatic cancer cells. By contrast, the concurrent inhibition of Stat3 and EGFR or Src induced greater viability loss and apoptosis, and diminished the migration/invasion of pancreatic cancer cells in vitro. Of therapeutic significance, the concurrent inhibition of Stat3 and EGFR or Src, as compared to mono-targeting modality, induced a stronger human pancreatic tumor growth inhibition in xenografts models. We infer that the large tumor growth inhibition in vivo is due to the simultaneous suppression of the abnormal functions of Stat3 and EGFR or Src. These studies strongly suggest that the concurrent targeting of Stat3 and EGFR or Src could be a beneficial therapeutic approach for pancreatic cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2528.
Oral administration of GW788388, an inhibitor of TGF-β type I and II receptor kinases, decreases renal fibrosis
Authors: M. Petersen, M. Thorikay, M. Deckers, M. van Dinther, E.T. Grygielko, F. Gellibert, A.C. de Gouville, S. Huet, P. ten Dijke, N.J. Laping
Journal: Kidney International (2007)
DETERMINATION WHETHER KETONURINE HAS BACTERICIDAL ACTION
Authors: ARNOLD E. OSTERBERG
Journal: JAMA (1934)

In a previous paper we reported, from chemical and bacteriologic data, that a minimal standard of pH and concentration of beta-hydroxybutyric acid could be set up for a ketonurine, and that if ketonurine met this standard it might be expected that it would prove to be bactericidal. These standards are a pH of 5.5 or less and a concentration of beta-hydroxybutyric acid of 0.5 per cent or greater. If these conditions are fulfilled, the urine is bactericidal to numerous strains of colon bacilli. If this standard is exceeded by a decrease in pH value or an increase in concentration of betahydroxybutyric acid, or both, it may be expected that the bactericidal action will be greater and the urine will be rendered sterile in a shorter length of time. The previous work involved the determination of the pH value of urine by ordinary colorimetric procedures and the determination of beta-hydroxybutyric acid
Surgery for Mitral Regurgitation
Authors: Lawrence H. Cohn
Journal: JAMA (1988)

Mitral regurgitation is a valvular heart lesion that is difficult to diagnose accurately; thus, it is difficult to determine the appropriate timing for surgical correction. With increasing use of reparative techniques, including local resection of valve pathology and placement of an annuloplasty ring, and the realization that chronic atrial fibrillation leads to decreased long-term survival, the timing of surgery has changed. In addition, serial noninvasive studies have indicated that despite the absence of symptoms, patients may progress to a myopathic condition if the regurgitation progresses over a long period and surgery is not performed when signs of left ventricular dysfunction are evident. Preservation of the papillary muscle is also extremely important for late postoperative function in patients with mitral regurgitation, and reparative surgery that preserves both anterior and posterior papillary muscle complexes and continuity with the anulus appears to satisfy this assumption. Worldwide experience is reviewed and I present conclusions related to the appropriate indications for mitral valve repair or replacement in patients with mitral regurgitation. (<i>JAMA</i>1988;260:2883-2887)