Lyme Disease Vaccines
Authors: Pierce Gardner
Journal: Annals of Internal Medicine (1998)

Editorials1 October 1998Lyme Disease VaccinesPierce Gardner, MDPierce Gardner, MDState University of New York at Stony Brook; Stony Brook, NY 11794-8432Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-7-199810010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Lyme disease is the most common tick-borne disease in the United States; 16 455 cases were reported in 1996 [1], and the actual incidence may be 10-fold higher [2]. In areas with a high incidence of Lyme disease, the licensing of vaccines against the causative spirochete, Borrelia burgdorferi, has been anticipated with great enthusiasm by the medical community and the general public. Two recombinant vaccines, each containing 30 µg of outer surface protein A (OspA), are in the final stages of approval by the U.S. Food and Drug Administration (FDA). The SmithKline Beecham product (LYMErix) contains an aluminum adjuvant, whereas ...References1. Lyme Disease-United States, 1996. MMWR Morb Mortal Wkly Rep. 1997; 46:531-5. Google Scholar2. Coyle BS, Strickland GT, Liang YY, Pena C, McCarter R, Israel E. The public health impact of Lyme disease in Maryland. J Infect Dis. 1996; 173:1260-2. Google Scholar3. Wormser GP. Prospects for a vaccine to prevent Lyme disease in humans. Clin Infect Dis. 1995; 21:1267-74. Google Scholar4. Steere AC, Sikand VK, Meurice F, Parenti DL, Fikrig E, Schoen RT, et al. Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group. N Engl J Med. 1998; 339:209-15. Google Scholar5. Sigal LH, Zahradnik JM, Lavin P, Patella SJ, Bryant G, Haselby R, et al. A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent Lyme disease. Recombinant Outer-Surface Protein A Lyme Disease Vaccine Study Consortium. N Engl J Med. 1998; 339:216-22. Google Scholar6. Fikrig E, Telford SR 3d, Barthold SW, Kantor FS, Spielman A, Flavell RA. Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice. Proc Natl Acad Sci U S A. 1992; 89:5418-21. Google Scholar7. Shih CM, Spielman A, Telford SR 3d. Short report: mode of action of protective immunity to Lyme disease spirochetes. Am J Trop Med Hyg. 1995; 52:72-4. Google Scholar8. Schoen RT, Fikrig E. Lyme disease vaccine: current status. In: Rahn DW, Evans J, eds. Lyme Disease. Philadelphia: American Coll Physicians; 1998:155-66. Google Scholar9. Schoen RT, Meurice F, Brunet CM, Cretella S, Krause DS, Craft JE, et al. Safety and immunogenicity of an outer surface protein A vaccine in subjects with previous Lyme disease. J Infect Dis. 1995; 172:1324-9. Google Scholar10. Dennis DT. Epidemiology, ecology and prevention of Lyme disease. In: Rahn DW, Evans J, eds. Lyme Disease. Philadelphia: American Coll Physicians; 1998:7-34. Google Scholar11. Barbour AG, Zuckert WR. Genome sequencing. New tricks of tick-borne pathogen. Nature. 1997; 390:553, 555. Google Scholar Author, Article, and Disclosure InformationAffiliations: State University of New York at Stony Brook; Stony Brook, NY 11794-8432Corresponding Author: Pierce Gardner, MD, Health Sciences Center, Level 4, Room 157, State University of New York at Stony Brook, Stony Brook, NY 11794-8432. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLyme BorreliosisCost-effectiveness analysis of the Lyme disease vaccineUpdate on Lyme Disease Vaccine: Focus on Dosing and Adverse EventsPEDIATRIC IMMUNIZATION FOR THE FUTUREBacterial diseasesTravel medicineLyme diseaseLyme Disease: Geography Predicts Risk 1 October 1998Volume 129, Issue 7Page: 583-585KeywordsAdverse reactionsAntibodiesChildrenFood and Drug AdministrationForecastingLyme diseaseSafetySpirochetesTicksVaccines Issue Published: 1 October 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...