tbuckley/cabot-search huggingface dataset:
Creatine Kinase Activity Following Strenuous Exertion
Authors: Leon A. Brown
Journal: JAMA (1982)

To the Editor.—  A number of reports have appeared in the medical literature that describe elevations in creatine kinase (CK) levels following physical exertion. Most of the attention in these articles has been focused on the occurrence of an MB isoenzyme, with emphasis that this isoenzyme may be of skeletal muscle origin and that its presence does not necessarily indicate a myocardial infarction ( JAMA 1981;246:2049). The possibility of diffuse myocytolysis of cardiac muscle has also been considered as a basis for MB isoenzyme appearance in such cases ( JAMA 1982;247:2368). A case of severe CK elevation following strenuous exertion occurred. Rather than focusing on the presence of an MB isoenzyme, which did appear in this case, we will emphasize the enormity of the total CK elevation possible under such circumstances.  Report of a Case.—  A total CK activity of 13,280 units/L (reference range, 50 to 325 units/L) was observed in a
Impaired Electrical Signaling Disrupts Gamma Frequency Oscillations in Connexin 36-Deficient Mice
Authors: Sheriar G. Hormuzdi, Isabel Pais, Fiona E.N. LeBeau, Stephen K. Towers, Andrei Rozov, Eberhard H. Buhl, Miles A. Whittington, Hannah Monyer
Journal: Neuron (2001)
VALUE OF CLASSICAL CRITERIA FOR DIAGNOSIS OF CARDIAC AMYLOID IN THE CARDIAC MAGNETIC RESONANCE ERA
Authors: Eduardo Pozo, Jose Castellano, Rajiv Deochand, Anubhav Kanwar, Maria Eduarda Menezes de Siqueira, Jorge Rodriguez-Garrido, Teresa Arias, Matthew Cham, Jagat Narula, Valentin Fuster, Javier Sanz
Journal: Journal of the American College of Cardiology (2014)
High-Tech Medicine and Rising Health Care Costs
Authors: Robert D. Gillette
Journal: JAMA (1990)

To  Editor.—  Ginzberg 1 addresses some major concerns relating to health care financing, but unfortunately he blurs  issues rather than clarifies them. He defines high-tech medicine as the sum of all  advances in medical knowledge and technique... during  past several decades. He makes no distinction between universally applicable, obviously cost-effective accomplishments such as rubella vaccine and other inventions (eg, mechanical respiration) that are lifesaving when correctly applied but not justifiable in relation to their cost if used inappropriately, as, for example, to prolong oxygenation of persons who have no chance of regaining meaningful life. Significant recent health care advances of a nontechnological nature, primarily in  area of relationships between illness and human behavior, 2,3 appear to have been ignored in  author's analysis.  The essay posits and then attempts to refute some global assertions that overstate what responsible critics of our health care system are
Preoperative chemotherapy for osteosarcoma with intravenous adriamycin and intra-arterial cis-platinum
Authors: R.S. Benjamin, S.P. Chawla, C.H. Carrasco, A.K. Raymond, J.A. Murray, T. Armen, S. Patel, S. Wallace, A. Ayala, N.E.J. Papadopoulos, C. Plager, M.M. Romsdahl, R.G. Martin
Journal: Annals of Oncology (1992)
The Hedgehog receptor Patched controls lymphoid lineage commitment
Authors: Anja Uhmann, Kai Dittmann, Frauke Nitzki, Ralf Dressel, Milena Koleva, Anke Frommhold, Arne Zibat, Claudia Binder, Ibrahim Adham, Mirko Nitsche, Tanja Heller, Victor Armstrong, Walter Schulz-Schaeffer, Jürgen Wienands, Heidi Hahn
Journal: Blood (2007)
Preventing diabetes in Bangladeshi people in Britain
Authors: S. Goenka
Journal: BMJ (2008)

The novel benzodioxopyrrolidine (S-16924) displays a clozapine-like profile of interaction with multiple monoaminergic receptors, in addition to potent agonist activity at serotonin (5-HT)<sub>1A</sub> receptors. S-16924 (2.5 mg/kg i.p.) and clozapine (5.0 mg/kg i.p.) generated robust discriminative stimuli (DS) and displayed full mutual generalization. The D<sub>4</sub> antagonists L-745,870 and S-18126, the D<sub>1</sub>/D<sub>5</sub>antagonist SCH-39166, and the D<sub>3</sub> antagonist S-14297 showed at most partial generalization to S-16924 and clozapine. The D<sub>2</sub>/D<sub>3</sub> antagonist raclopride fully generalized to S-16924, but only partially generalized to clozapine. The 5-HT<sub>2A</sub> antagonist MDL-100,907 fully generalized to S-16924 and two further 5-HT<sub>2A</sub> antagonists, fananserin and SR-46349, showed partial generalization. However, MDL-100,907, fananserin, and SR-46349 showed less pronounced generalization to clozapine. Similarly, the 5-HT<sub>2C</sub> antagonists SB-200,646 and SB-206,553 more markedly generalized to S-16924 than to clozapine. The 5-HT<sub>1A</sub> receptor agonist (±)-8-dihydroxy-2-(di-<i>n</i>-propylamino) tetralin generalized fully to S-16924 but not to clozapine. Full generalization was obtained to both S-16924 and clozapine for the clozapine congeners, olanzapine and quetiapine. In distinction, the benzisoxazole, risperidone, and the phenylindole, sertindole, weakly generalized to S-16924 and clozapine. However, the benzisoxazole ziprasidone, which possesses 5-HT<sub>1A</sub> agonist properties, generalized fully to S-16924 but not to clozapine. Finally, the muscarinic antagonist scopolamine generalized fully to clozapine and partially to S-16924. In conclusion, S-16924 and clozapine display both communalities and differences in their “compound” DS; this likely reflects their respective complex patterns of interaction with multiple monoaminergic receptors. Although no specific receptor was identified as underlying the clozapine DS, 5-HT<sub>1A</sub> agonist as well as D<sub>2</sub> and 5-HT<sub>2A/2C</sub> antagonist properties contribute to the S-16924 DS.
Evidence for a distinct gap-junctional phenotype in ventricular conduction tissues of the developing and mature avian heart.
Authors: R G Gourdie, C R Green, N J Severs, R H Anderson, R P Thompson
Journal: Circulation Research (1993)

The gap-junctional proteins connexin43 and connexin42 have been shown to be expressed in the developing and mature avian heart, but their respective spatiotemporal distributions are unknown. In the present study, we have immunolocalized connexin42 in the conduction tissues of the adult avian heart (nonbranching bundle, bundle branches, and Purkinje fibers) and vascular endothelial cells. Connexin43 immunolabeling was confined to vascular smooth muscle. A novel microwave-based method was used to label connexin42 and connexin43 in the same tissue section. Neither connexin42 nor connexin43 was immunolocalized in working myocardium, atrioventricular node, and atrioventricular ring tissue of the bird heart. Although connexin42 first appeared in periarterial conduction myocytes and vascular endothelium at 9-10 embryonic days, the central conduction tissues, including the nonbranching bundle and proximal branches, remained immunonegative for connexin42 up until hatching (approximately 20 embryonic days). During the early postnatal period (1-14 days), connexin42 immunolabeling progressively spread up the bundle branches toward the nonbranching bundle. Connexin42 appeared uniformly distributed along the left bundle branch by 14 postnatal days. The distribution and spread of connexin42 immunoreactivity suggest that the emergence of specialized junctional contacts along ventricular fascicles occurs relatively late in heart development and coincides with the emergence of the chick from incubation within the egg.
FACTORS ASSOCIATED WITH A REDUCTION OF LIPID CORE PLAQUE IN PATIENTS UNDERGOING PCI: NEAR-INFRARED SPECTROSCOPY RESULTS FROM THE COLOR REGISTRY
Authors: Cristiano Souza, Tomotaka Dohi, Akiko Maehara, Annapoorna Kini, David Rizik, Emmanouil Brilakis, Kendrick Shunk, Brijeshwar Maini, Priti Shah, Kosaku Goto, Mitsuaki Matsumura, Ke Xu, Gregg Stone, Gary Mintz, James Muller, Giora Weisz
Journal: Journal of the American College of Cardiology (2014)
Radiotherapy for Acne And Thyroid Carcinoma
Authors: David R. Weakley
Journal: JAMA (1967)

To the Editor:—  Recognizing that without proper shielding of the neck the thyroid gland may receive undetermined amounts of irradiation, E. J. Albright and R. W. Allday found five interesting patients who received x-ray therapy for acne vulgaris in adolescence, only to develop thyroid carcinoma years later ( 199 :280, 1967). They contend that because a causal relationship between incidental radiation to the thyroid and carcinogenesis cannot be disproved, radiation therapy for acne and other benign diseases of the head and neck should be abandoned in the adolescent patient.  Mutilating acne vulgaris is a major medical problem deserving of sympathetic medical care, and one that sometimes requires x-ray therapy for control.  No existent evidence incriminates x-ray therapy given for acne as a cause of thyroid cancer if the gland is shielded in the standard fashion.
My Academic Life
Authors: H. A. Harris
Journal: BMJ (1951)

On September 13, -1886, I made my appearance on a Monday-washing day.I always could be awkward.I was born within the gates of the ironworks at Rhymney, Monmouthshire.My father, a hard-working and indus- trious man, the fourth generation of master iron-workers, was manager of the Bessemer steel plant.My mother was a vigorous, courageous, and shrewd woman who had inherited the toughness and moral fibre of her sturdy Nonconformist Radnorshire stock.I was the youngest of six children.Within four years of my birth the lights went out of the melting pots, the fires were drawn, and Rhymney ironworks became derelict.
Letter: Spares for anaesthetic machines.
Authors: D E Walker
Journal: BMJ (1976)

cases of significant bacteraemia following proctoscopic biopsy of a rectal polyp3 and barium enema4 both patients had a signifi- cantly altered immune state.The risk of significant bacteraemia following rectal mucosal biopsy is probably small, as no cases have previously been reported.However, it should be borne in mind, particularly in a patient with an altered immune state or in a patient at risk from bacterial endocarditis.
Chlorogenic acid loaded chitosan nanoparticles with sustained release property, retained antioxidant activity and enhanced bioavailability
Authors: Ilaiyaraja Nallamuthu, Aishwarya Devi, Farhath Khanum
Journal: Asian Journal of Pharmaceutical Sciences (2014)

In this study, chlorogenic acid (CGA), a phenolic compound widely distributed in fruits and vegetables, was encapsulated into chitosan nanoparticles by ionic gelation method. The particles exhibited the size and zeta potential of 210 nm and 33 mV respectively. A regular, spherical shaped distribution of nanoparticles was observed through scanning electron microscopy (SEM) and the success of entrapment was confirmed by FTIR analysis. The encapsulation efficiency of CGA was at about 59% with the loading efficiency of 5.2%. In vitro ABTS assay indicated that the radical scavenging activity of CAG was retained in the nanostructure and further, the release kinetics study revealed the burst release of 69% CGA from nanoparticles at the end of 100th hours. Pharmacokinetic analysis in rats showed a lower level of Cmax, longer Tmax, longer MRT, larger AUC0–t and AUC0–∞ for the CGA nanoparticles compared to free CGA. Collectively, these results suggest that the synthesised nanoparticle with sustained release property can therefore ease the fortification of food-matrices targeted for health benefits through effective delivery of CGA in body.
Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice
Authors: Hannelie Korf, Seppe Vander Beken, Marta Romano, Knut R. Steffensen, Benoît Stijlemans, Jan-υke Gustafsson, Johan Grooten, Kris Huygen
Journal: Journal of Clinical Investigation (2009)

Liver X receptors (LXRs) are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. However, exactly how LXRs modulate inflammation during infection remains unknown. To explore this, we used a mouse model of Mycobacterium tuberculosis infection. Upon intratracheal infection with M. tuberculosis, LXRs and LXR target genes were induced in CD11c+ lung and alveolar cells. Furthermore, mice deficient in both LXR isoforms, LXRα and LXRβ (Lxra–/–Lxrb–/– mice), were more susceptible to infection, developing higher bacterial burdens and an increase in the size and number of granulomatous lesions. Interestingly, mice solely deficient in LXRα, but not those lacking only LXRβ, mirrored the susceptibility of the Lxra–/–Lxrb–/– animals. Lxra–/–Lxrb–/– mice failed to mount an effective early neutrophilic airway response to infection and showed dysregulation of both pro- and antiinflammatory factors in CD11c+ lung cells. T cell responses were strongly affected in Lxra–/–Lxrb–/– mice, showing near-complete abrogation of the infection-induced Th1 function — and even more so Th17 function — in the lungs. Treatment of WT mice with the LXR agonists TO901317 and GW3965 resulted in a 10-fold decrease of the pulmonary bacterial burden and a comparable increase of Th1/Th17 function in the lungs. The dependence of LXR signaling on the neutrophil IL-17 axis represents what we believe to be a novel function for these nuclear receptors in resistance to M. tuberculosis infection and may provide a new target for therapeutics.
P1214 RIBAVIRIN MONOTHERAPY REDUCES HCVRNA IN ASSOCIATION WITH IL28B GENOTYPE AND ALSO IP-10 CONCENTRATIONS AMONG PATIENTS INFECTED WITH HEPATITIS C GENOTYPE 1
Authors: J. Waldenström, J. Westin, K. Nyström, P. Christensen, O. Dalgard, M. Färkkila, K. Lindahl, G. Norkrans, H. Norrgren, M.R. Buhl, S. Stenmark, M. Lagging
Journal: Journal of Hepatology (2014)
Feasibility of targeted next-generation sequencing of the TP53 and ATM genes in chronic lymphocytic leukemia
Authors: L Mansouri, L-A Sutton, V Ljungström, E F Sörqvist, R Gunnarsson, K E Smedby, G Juliusson, K Stamatopoulos, M Nilsson, R Rosenquist
Journal: Leukemia (2013)
1001-28 Stenotic Lesions Reliably Form in Porcine Coronary Arteries Using Copper Stents or Intracoronary Heating
Authors: Michael E. Staab, Daniel K. Meeker, William D. Edwards, Sanjay S. Srivatsa, Myung Ho Jeong, David R. Holmes, Robert S. Schwartz
Journal: Journal of the American College of Cardiology (1995)
Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family
Authors: Jennifer J. McIntire, Sarah E. Umetsu, Omid Akbari, Michael Potter, Vijay K. Kuchroo, Gregory S. Barsh, Gordon J. Freeman, Dale T. Umetsu, Rosemarie H. DeKruyff
Journal: Nature Immunology (2001)
Urinary Excretion of Catecholamines during the First Months after Delivery
Authors: Töres Theorell, Birgitta Wikander
Journal: Psychotherapy and Psychosomatics (1995)

The urinary excretion of free catecholamines was assessed in 17 women 3 times after delivery; after 3 weeks, 6 weeks and 6 months, respectively. Relatively high levels were found both for adrenaline and noradrenaline excretion, on the first and third occasions, with significantly lowered levels on the second one. Mothers who had had a negative experience of their delivery (according to interview) as well as mothers who felt tired during the mid-phase of the follow-up (according to diaries) had very small variations in catecholamine excretion and did not show increased levels 6 months after delivery. Whether the mother experienced her infant as crying or not had no significant association with catecholamine output.
Achievement of VGPR to induction therapy is an important prognostic factor for longer PFS in the IFM 2005-01 trial
Authors: Philippe Moreau, Michel Attal, Brigitte Pégourié, Lucie Planche, Cyrille Hulin, Thierry Facon, Anne-Marie Stoppa, Jean-Gabriel Fuzibet, Bernard Grosbois, Chantal Doyen, Nicolas Ketterer, Catherine Sebban, Brigitte Kolb, Carine Chaleteix, Mamoun Dib, Laurent Voillat, Jean Fontan, Laurent Garderet, Jérôme Jaubert, Claire Mathiot, Dixie Esseltine, Hervé Avet-Loiseau, Jean-Luc Harousseau
Journal: Blood (2010)
Tc-99m MAG3 as an Alternative to Tc-99m DTP A and I-131 Hippuran for Renal Transplant Evaluation
Authors: JANIS P. O??MALLEY, HARVEY A. ZIESSMAN, NANTIYA CHANTARAPITAK
Journal: Clinical Nuclear Medicine (1993)

This study investigated the new radiopharmaceutical, Tc-99m mercaptoacetyltriglycine (MAG3), as a possible alternative to Tc-99m DTPA and I-131 Hippuran for renal transplant evaluation. Tc-99m MAG3 and I-131 Hippuran were used sequentially in 19 consecutive patient studies and compared qualitatively and quantitatively. Serum creatinine values ranged from 1.6 mg/dL to 10.3 mg/dL (mean, 5.4 mg/dL). The Tc-99m MAG3 images and time-activity curves were of superior quality (3+) compared to I-131 Hippuran (1-2+). Quantitative analysis of the time to peak activity (Tmax) demonstrated a high correlation and no significant difference for Tc-99m MAG3 (mean, 11.4 min) compared to I-131 Hippuran (mean, 11.2 min). The percentage of peak activity retained at 20 minutes (T20) also showed a high correlation between the two agents; however, Tc-MAG3 showed a significantly slower clearance (T20 mean, 77%) than I-131 Hippuran (mean, 71%). Flow images were judged to be of good quality; however, the first-pass time-activity curves were often different from that seen with Tc-99m DTPA. Interpretation of delayed Tc-99m MAG3 images, for example to diagnose a slow urinary leak, were sometimes complicated by bowel clearance. In conclusion, Tc-99m MAG3 is superior to I-131 Hippuran for evaluation of renal transplant function. Tc-99m is the agent of choice for evaluation of renal transplant blood flow and function.
Guidelines for bronchoprovocation on the investigation of occupational asthma Report of the Subcommittee on Bronchoprovocation for Occupational Asthma
Authors: A CARTIER, I BERNSTEIN, P BURGE, J COHN, L FABBRI, F HARGREAVE, J MALO, R MCKAY, J SALVAGGIO
Journal: Journal of Allergy and Clinical Immunology (1989)
The Blood Bank and the Technique and Therapeutics of Transfusions
Authors: Robert Anthony Kilduffe, Michael Ellis DeBakey
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Imaging of brain and brain tumor specimens by time-resolved multiphoton excitation microscopy ex vivo1
Authors: Sven R. Kantelhardt, Jan Leppert, Jochen Krajewski, Nadine Petkus, Erich Reusche, Volker M. Tronnier, Gereon Hüttmann, Alf Giese
Journal: Neuro-Oncology (2007)

Multiphoton excitation fluorescent microscopy is a laser-based technology that allows subcellular resolution of native tissues in situ. We have recently applied this technology to the structural and photochemical imaging of cultured glioma cells and experimental gliomas ex vivo. We demonstrated that high microanatomical definition of the tumor, invasion zone, and normal adjacent brain can be obtained down to single-cell resolution in unprocessed tissue blocks. In this study, we used multiphoton excitation and four-dimensional microscopy to generate fluorescence lifetime maps of the murine brain anatomy, experimental glioma tissue, and biopsy specimens of human glial tumors. In murine brain, cellular and noncellular elements of the normal anatomy were identified. Distinct excitation profiles and lifetimes of endogenous fluorophores were identified for specific brain regions. Intracranial grafts of human glioma cell lines in mouse brain were used to study the excitation profiles and fluorescence lifetimes of tumor cells and adjacent host brain. These studies demonstrated that normal brain and tumor could be distinguished on the basis of fluorescence intensity and fluorescence lifetime profiles. Human brain specimens and brain tumor biopsies were also analyzed by multiphoton microscopy, which demonstrated distinct excitation and lifetime profiles in glioma specimens and tumor-adjacent brain. This study demonstrates that multiphoton excitation of autofluorescence can distinguish tumor tissue and normal brain based on the intensity and lifetime of fluorescence. Further technical developments in this technology may provide a means for in situ tissue analysis, which might be used to detect residual tumor at the resection edge.
Prediction models of long-term Cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: Risk scores integrating host and virus profiles
Authors: Mei-Hsuan Lee, Hwai-I. Yang, Jessica Liu, Richard Batrla-Utermann, Chin-Lan Jen, Uchenna H. Iloeje, Sheng-Nan Lu, San-Lin You, Li-Yu Wang, Chien-Jen Chen
Journal: Hepatology (2013)

Integrating host and HBV characteristics, this study aimed to develop models for predicting long-term cirrhosis and hepatocellular carcinoma (HCC) risk in chronic hepatitis B virus (HBV) patients. This analysis included hepatitis B surface antigen (HBsAg)-seropositive and anti-HCV-seronegative participants from the Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer in HBV (R.E.V.E.A.L.-HBV) cohort. Newly developed cirrhosis and HCC were ascertained through regular follow-up ultrasonography, computerized linkage with national health databases, and medical chart reviews. Two-thirds of the participants were allocated for risk model derivation and another one-third for model validation. The risk prediction model included age, gender, HBV e antigen (HBeAg) serostatus, serum levels of HBV DNA, and alanine aminotransferase (ALT), quantitative serum HBsAg levels, and HBV genotypes. Additionally, the family history was included in the prediction model for HCC. Cox's proportional hazards regression coefficients for cirrhosis and HCC predictors were converted into risk scores. The areas under receiver operating curve (AUROCs) were used to evaluate the performance of risk models. Elder age, male, HBeAg, genotype C, and increasing levels of ALT, HBV DNA, and HBsAg were all significantly associated with an increased risk of cirrhosis and HCC. The risk scores estimated from the derivation set could accurately categorize participants with low, medium, and high cirrhosis and HCC risk in the validation set (P<0.001). The AUROCs for predicting 3-year, 5-year, and 10-year cirrhosis risk ranged 0.83-0.86 and 0.79-0.82 for the derivation and validation sets, respectively. The AUROC for predicting 5-year, 10-year, 15-year risk of HCC ranged 0.86-0.89 and 0.84-0.87 in the derivation and validation sets, respectively.The risk prediction models of cirrhosis and HCC by integrating host and HBV profiles have excellent prediction accuracy and discriminatory ability. They may be used for clinical management of chronic hepatitis B patients.
HYPERTROPHY OF THE MALE NIPPLE IN LEPROSY
Authors: A. POWELL
Journal: British Journal of Dermatology (1924)

Journal Article HYPERTROPHY OF THE MALE NIPPLE IN LEPROSY Get access A. POWELL, O.B.E., M.B., M.Ch. A. POWELL, O.B.E., M.B., M.Ch. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 36, Issue 5, 1 May 1924, Page 203, https://doi.org/10.1111/j.1365-2133.1924.tb09184.x Published: 01 May 1924