tbuckley/cabot-search huggingface dataset:
Characteristics of patients with drug resistant and drug sensitive tuberculosis in East London between 1984 and 1992.
Authors: N al Jarad, S Parastatides, E A Paul, C D Sheldon, H Gaya, R M Rudd, D W Empey
Journal: Thorax (1994)

<h3>SUMMARY</h3> Most natural odors are complex mixtures of many volatile components, competing to bind odorant receptors (ORs) expressed in olfactory sensory neurons (OSNs) of the nose. To date surprisingly little is known about how OR antagonism shapes neuronal representations in the periphery of the olfactory system. Here, we investigated its prevalence, the degree to which it disrupts OR ensemble activity, and its conservation across related ORs. Calcium imaging microscopy of dissociated OSNs revealed significant inhibition, often complete attenuation, of responses to indole, a commonly occurring volatile associated with both floral and fecal odors, by a set of 36 tested odorants. To confirm an OR mechanism for the observed inhibition, we performed single-cell transcriptomics on OSNs that exhibited specific response profiles to a diagnostic panel of odorants and identified the receptor Olfr743 which, when tested <i>in vitro</i>, recapitulated <i>ex vivo</i> responses. We screened ten ORs from the Olfr743 clade with 800 perfumery-related odorants spanning a range of chemical scaffolds and functional groups, over half of which (430) antagonized at least one of the ten ORs. Furthermore, OR activity outcomes were divergent rather than redundant, even for the most closely related paralogs. OR activity fitted a mathematical model of competitive receptor binding and suggests that normalization of OSN ensemble responses to odorant mixtures is the rule rather than the exception. In summary, we observed OR antagonism, inverse agonism and partial agonism occurring frequently and in a combinatorial manner. Thus, extensive receptor-mediated computation of mixture information appears to occur in the olfactory epithelium prior to transmission of odor information to the olfactory bulb.
A Psychological Study of Patients with Rheumatoid Arthritis and Other Painful Diseases.
Authors: Harry Robinson
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972A Psychological Study of Patients with Rheumatoid Arthritis and Other Painful Diseases.Harry Robinson, Sc.D., Robert F. Kirk Jr., M.S., Roland F. Frye, Ph.D., James T. Robertson, M.D.Harry Robinson, Sc.D.Search for more papers by this author, Robert F. Kirk Jr., M.S.Search for more papers by this author, Roland F. Frye, Ph.D.Search for more papers by this author, James T. Robertson, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-881_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA previous study found evidence of a personality profile in patients with rheumatoid arthritis compared with three groups of patients with chronic nonpainful diseases. To see whether these results represented a unique rheumatoid arthritis personality or a reflection of the pain forcing patients to a common personality mold, three additional groups of patients were formed and tested. Again the instrument used was Cattell's 16 Personality Factor test. The first group consisted of "new" patients with rheumatoid arthritis with a recent medical diagnosis and "old" rheumatoid arthritis patients who were diagnosed more than 3 years before testing; the second group was... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Memphis, Tenn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 881-882KeywordsPainRheumatic painRheumatoid arthritis Issue Published: 1 May 1972 PDF downloadLoading ...
Clinical Lecture on a Case of Comminuted Fracture of the Clavicle, with Compression of the Subclavian Vein by One of the Fragments
Authors: J. Erichsen
Journal: BMJ (1873)

GENTLEMEN,-The case to which I wish to direct your attention to-day is one of a comminuted fracture of the clavicle from direct violence, ac- companied by compression of the subclavian vein by one of the frag- ments, which resulted in gangrene of the arm.William Anstis, aged 27, a married man, who had always enjoyed a good health, and was of temperate habits, whilst assisting in moving some timber, received a severe blow, from a large mass of it falling on his shoulder, on Thursday, March 20th, I873 ; and, finding the arm powerless, he applied to a medical man, who adjusted a sling, and sent him to University College Hospital.There it was found that the clavicle was broken and comminuted about the middle; several movable and depressed fragments being felt beneath the skin.As some fulness
Phase I study of obatoclax mesylate (GX15-070), a small molecule pan–Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia
Authors: Susan M. O'Brien, David F. Claxton, Michael Crump, Stefan Faderl, Thomas Kipps, Michael J. Keating, Jean Viallet, Bruce D. Cheson
Journal: Blood (2008)
How to stop making a crisis out of a drama: towards better portrayal of mental ill health in television and film
Authors: R. Carter
Journal: BMJ (2015)

The relation between the bone histomorphometric profile of the iliac crest and regions of the proximal femur was investigated. In the proximal femur four blocks were selected, representing the subchondral principal compressive (SPC) and tensile (SPT) regions, the zone near the medial cortex in the principal compressive region (MPC), and the zone medial to the greater trochanter (MGT). Undecalcified tissue sections stained by the von Kossa silver method and counterstained with haematoxylin and eosin were used for quantitation. The SPT region was most representative of the iliac bone profile, in particular the structural parameters of mineralised bone, trabecular thickness, and trabecular spacing and resorption surface. Most parameters in the regions studied showed inconsistent and variable results when compared with those of the iliac crest. There was only a weak association, therefore, between the histomorphometric parameters of the iliac crest and the proximal femur despite the appeal of the use of the iliac biopsy specimen as a simple clinical test.
Prolonged pancytopenia in a gene therapy patient with ADA-deficient SCID and trisomy 8 mosaicism: a case report
Authors: Barbara C. Engel, Greg M. Podsakoff, Joanna L. Ireland, E. Monika Smogorzewska, Denise A. Carbonaro, Kathy Wilson, Ami Shah, Neena Kapoor, Mirna Sweeney, Mark Borchert, Gay M. Crooks, Kenneth I. Weinberg, Robertson Parkman, Howard M. Rosenblatt, Shi-Qi Wu, Michael S. Hershfield, Fabio Candotti, Donald B. Kohn
Journal: Blood (2006)
111In-labeled platelet scintigraphy and two-dimensional echocardiography for detection of left atrial appendage thrombi. Studies in a new canine model.
Authors: B F Vandenberg, J E Seabold, G R Conrad, R Kieso, J Johnson, K Fox-Eastham, J Ponto, P Bruch, R E Kerber
Journal: Circulation (1988)

111In-labeled platelet scintigraphy and two-dimensional echocardiography were performed in 40 dogs to determine the ability of the two techniques to detect left atrial appendage thrombi. Thrombi were induced in 33 dogs that were classified into two groups, "acute" or "chronic," according to the time of labeled-platelet injection after thrombus induction. In the acute group (17 dogs), platelets were injected 24 hours after thrombus induction. In the chronic group (16 dogs), platelets were injected 4-8 days after thrombus induction. "Sham" thoracotomies were performed on seven additional control dogs who did not receive thrombin injections. Analog and blood pool-corrected 111In-labeled platelet scintigraphy images were obtained 4-72 hours later. Closed-chest two-dimensional echocardiography was performed before thoracotomy and repeated at the time of scintigraphy. The location and size of each thrombus were verified at autopsy. Two-dimensional echocardiography detected three of 17 acute (mean volume, 1.2 +/- 1.0 cc) and three of 10 chronic (mean volume, 0.4 +/- 0.3 cc; p less than 0.025) left atrial appendage thrombi. 111In-labeled platelet scintigraphy detected all 17 acute thrombi but only two of 10 chronic thrombi. The measured radioactivity levels of the excised thrombi were 1,949 +/- 1,665 cpm/clot/dose in group 1 and 228 +/- 213 cpm/clot/dose in group 2 (p less than 0.005). In this model, 111In-labeled platelet scintigraphy was able to detect acute left atrial appendage thrombi that could not be identified by two-dimensional echocardiography. Both techniques showed poor sensitivity for detection of chronic thrombi. The decline in sensitivity of 111In-labeled platelet scintigraphy for detection of older thrombi is probably due to diminished labeled-platelet incorporation.
Dr. Janusz Korczak
Authors: Roy J. Popkin
Journal: New England Journal of Medicine (1963)

DR. Janusz Korczak, physician, educator and writer, was born in Poland on July 22, 1879, and died tragically with the children of his orphanage at the hands of the Nazis on August 5, 1942, during the battle of the Warsaw Ghetto. Referred to by many as an educator-saint, he is claimed as a national hero in education in Poland and Israel.Korczak, whose true name was Henryk Goldszmit, assumed early in his career the name by which he was known to millions of Polish children and adults. After graduation from the University of Warsaw Medical School he continued his studies . . .
German government considers ending funding of marketing courses for doctors
Authors: A. Tuffs
Journal: BMJ (2012)

Germany’s Department of Trade and Industry has announced that it is considering withdrawing funding for courses that train doctors to sell so called individual health services, after wide criticism.

The individual health services most often promoted by doctors include various diagnostic and therapeutic procedures as well as counselling. Because they are not evidence based, they are not covered by statutory health insurance, and patients have to pay for them …
Low frequency of detection by nested polymerase chain reaction of enterovirus ribonucleic acid in endomyocardial tissue of patients with idiopathic dilated cardiomyopathy
Authors: Mauro Giacca, Giovanni Maria Severini, Luisa Mestroni, Alessandro Salvi, Gerardina Lardieri, Arturo Falaschi, Fulvio Camerini
Journal: Journal of the American College of Cardiology (1994)
Suicide in Chronic Hemodialysis Patients from an External Locus of Control Framework
Authors: ALAN M. GOLDSTEIN, MARVIN REZNIKOFF
Journal: American Journal of Psychiatry (1971)

Long-term hemodialysis patients have an alarmingly high suicide rate. Deaths that result from the patient's lack of adherence to the treatment regimen have in the past been viewed from a suicidal framework. The authors suggest that such behavior may be more fruitfully regarded as an attempt by the patient to reduce the anxiety resulting from the recognition of his tremendous responsibility in the treatment program.
Rheumatoid Arthritis and Pure Red Cell Aplasia
Authors: EMMANUEL N. DESSYPRIS
Journal: Annals of Internal Medicine (1984)

Three patients with severe, deforming, and long-standing rheumatoid arthritis developed pure red cell aplasia that did not remit after withdrawal of medications, ran a chronic course, and in two patients remitted only after cytotoxic immunosuppressive treatment. An IgG inhibitor of autologous erythroid colony-forming and burst-forming unit growth in vitro was found in the serum of one patient. This specific erythropoietic inhibitor persisted in lower titer in the patient's serum even after an azathioprine-induced remission of pure red cell aplasia, indicating the possible need for maintenance immunosuppressive therapy. Chronic pure red cell aplasia may be another extra-articular manifestation of rheumatoid arthritis and should be considered when severe anemia develops in the absence of blood loss or hemolysis.
Incubation with IgE increases cholinergic neurotransmission in human airways in vitro.
Authors: M Ichinose, M Miura, M Tomaki, T Oyake, N Kageyama, Y Ikarashi, Y Maruyama, K Shirato
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

Airway cholinergic hyperresponsiveness is frequently observed in asthmatic patients. Recent reports suggest the possible involvement of IgE in hyperresponsiveness, although the exact mechanism is still uncertain. In this study, we examined whether incubation with IgE could facilitate the cholinergic function in human airways. Bronchi were obtained from 20 patients undergoing lung resection. Cholinergic contractile responses were induced by electrical field stimulation (EFS) or exogenous acetylcholine (ACh), and they were assessed by isometric tension measurement. EFS-induced ACh release from cholinergic nerves was also measured by high performance liquid chromatography. Incubation with IgE significantly enhanced EFS-induced bronchial contraction and ACh release as compared with the values of the bronchi incubated with heat inactivated IgE (control) (p < 0.05, respectively), but it did not alter the contractile responses induced by exogenous ACh. Pretreatment with the muscarinic M2-receptor agonist pilocarpine reduced the EFS-induced ACh release in the control tissues (p < 0.05), but not in the tissues incubated with IgE. The M2-receptor antagonist methoctramine significantly enhanced the EFS-induced contraction in control bronchi (p < 0.05), but this augmentation was not observed in the tissues incubated with IgE. These results suggest that IgE itself can enhance cholinergic bronchial contraction via facilitation of ACh release from cholinergic nerves and that this augmentation is related to autoreceptor M2 dysfunction at nerve endings.
CDC: Use of Emerging Tobacco Products Increasing Among US Youths
Authors: Mike Mitka
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genome Informatics
Authors: Raimond L. Winslow, Mark S. Boguski
Journal: Circulation Research (2003)

This article reviews recent advances in genomics and informatics relevant to cardiovascular research. In particular, we review the status of (1) whole genome sequencing efforts in human, mouse, rat, zebrafish, and dog; (2) the development of data mining and analysis tools; (3) the launching of the National Heart, Lung, and Blood Institute Programs for Genomics Applications and Proteomics Initiative; (4) efforts to characterize the cardiac transcriptome and proteome; and (5) the current status of computational modeling of the cardiac myocyte. In each instance, we provide links to relevant sources of information on the World Wide Web and critical appraisals of the promises and the challenges of an expanding and diverse information landscape.
Endocardial mapping of ventricular tachycardia in the intact human heart. II. Evidence for multiuse reentry in a functional sheet of surviving myocardium
Authors: Eugene Downar, Shane Kimber, Louise Harris, Lynda Mickleborough, Elias Sevaptsidis, Stephane Masse, Thomas C.K. Chen, Adriana Genga
Journal: Journal of the American College of Cardiology (1992)
Hyperpyrexia During Anaesthesia
Authors: G. G. Harrison, J. F. Biebuyck, J. Terblanche, D. M. Dent, R. Hickman, S. J. Saunders
Journal: BMJ (1968)

Work in pigs has shown that malignant hyperpyrexia during anaesthesia may occur without suxamethonium having been given. A virtually constant feature in reported cases and in our own observations is that all subjects developing hyperpyrexia had received nitrous oxide and halothane.
Hereditary Systemic Amyloidosis Due to Asp76Asn Variant β<sub>2</sub>-Microglobulin
Authors: Sophie Valleix, Julian D Gillmore, Franck Bridoux, Palma P Mangione, Ahmet Dogan, Brigitte Nedelec, Mathieu Boimard, Guy Touchard, Jean-Michel Goujon, Corinne Lacombe, Pierre Lozeron, David Adams, Catherine Lacroix, Thierry Maisonobe, Violaine Planté-Bordeneuve, Julie A Vrana, Jason D Theis, Sofia Giorgetti, Riccardo Porcari, Stefano Ricagno, Martino Bolognesi, Monica Stoppini, Marc Delpech, Mark B Pepys, Philip N Hawkins, Vittorio Bellotti
Journal: New England Journal of Medicine (2012)

We describe a kindred with slowly progressive gastrointestinal symptoms and autonomic neuropathy caused by autosomal dominant, hereditary systemic amyloidosis. The amyloid consists of Asp76Asn variant β(2)-microglobulin. Unlike patients with dialysis-related amyloidosis caused by sustained high plasma concentrations of wild-type β(2)-microglobulin, the affected members of this kindred had normal renal function and normal circulating β(2)-microglobulin values. The Asp76Asn β(2)-microglobulin variant was thermodynamically unstable and remarkably fibrillogenic in vitro under physiological conditions. Previous studies of β(2)-microglobulin aggregation have not shown such amyloidogenicity for single-residue substitutions. Comprehensive biophysical characterization of the β(2)-microglobulin variant, including its 1.40-Å, three-dimensional structure, should allow further elucidation of fibrillogenesis and protein misfolding.
The shrinking man. A manifestation of severe renal osteodystrophy
Authors: M. L. Horensten
Journal: JAMA (1980)

A 37-year-old man, who had been undergoing hemodialysis for nine years, had severe osteodystrophy with a consequent 28-cm loss in height. This shrinkage in size is probably secondary to tertiary hyperparathyroidism. In spite of two previous explorations, there is still evidence of hyperparathyroidism and his present condition precludes surgical intervention. (<i>JAMA</i>244:267-268, 1980)
Insulin Pump Treatment in Insulin-Dependent Diabetes Mellitus
Authors: Stuart J. Brink
Journal: JAMA (1986)

Twenty-four children, teenagers, and young adults (8 to 26 years old) with insulin-dependent diabetes mellitus were treated with continuous subcutaneous insulin infusion (CSII). Criteria for using CSII included persistent high glycohemoglobin (GHb) values and/or wide swings in blood glucose values despite arduous efforts to improve glycemia. Thirty percent discontinued CSII. Improvement was significant by three months for GHb and blood glucose values, but plateaued thereafter. Only three patients attained a normal GHb value. No predictors for degree of control were identified. Diabetic ketoacidosis did not occur more frequently with CSII. Electromechanical problems with the devices, patient errors, or local skin problems occurred in 50% of patients, although none produced ketoacidosis or severe hypoglycemia. Dietary noncompliance and decreased intensive home monitoring were contributory factors. Better ways to predict success or failure are needed if normalization or even near-normalization is a goal of CSII in younger patients with insulin-dependent diabetes mellitus followed up in a nonresearch setting.
Combined therapy with oral retinoid and PUVA baths in severe psoriasis
Authors: G. Michaelsson, P. Noren, A. Vahlquist
Journal: British Journal of Dermatology (1978)

Journal Article Combined therapy with oral retinoid and PUVA baths in severe psoriasis Get access G. Michaëlsson, G. Michaëlsson Department of Dermatology, University Hospital, Uppsala, Sweden Search for other works by this author on: Oxford Academic Google Scholar P. Norén, P. Norén Department of Dermatology, University Hospital, Uppsala, Sweden Search for other works by this author on: Oxford Academic Google Scholar A. Vahlquist A. Vahlquist Department of Dermatology, University Hospital, Uppsala, Sweden Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 99, Issue 2, 1 August 1978, Pages 221–222, https://doi.org/10.1111/j.1365-2133.1978.tb01987.x Published: 01 August 1978
Atorvastatin decreases cellular proliferation and bone matrix expression in the hypercholesterolemic mitral valve
Authors: Babu Makkena, Hani Salti, Malayannan Subramaniam, Senthil Thennapan, Robert H. Bonow, Frank Caira, Robert O. Bonow, Thomas C. Spelsberg, Nalini M. Rajamannan
Journal: Journal of the American College of Cardiology (2005)