tbuckley/cabot-search huggingface dataset:
Cost-effectiveness of Methods to Enhance Sensitivity of Papanicolaou Testing
Authors: Nancy Kline Leidy
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nef-Mediated Lipid Raft Exclusion of UbcH7 Inhibits Cbl Activity in T Cells to Positively Regulate Signaling
Authors: Alison Simmons, Bevin Gangadharan, Ashleigh Hodges, Katherine Sharrocks, Sripadi Prabhakar, Angel García, Raymond Dwek, Nicole Zitzmann, Andrew McMichael
Journal: Immunity (2005)
Systematic Review and Meta-Analysis of Randomized and Nonrandomized Trials on Safety and Efficacy of Video-Assisted Thoracic Surgery Lobectomy for Early-Stage Non–Small-Cell Lung Cancer
Authors: Tristan D. Yan, Deborah Black, Paul G. Bannon, Brian C. McCaughan
Journal: Journal of Clinical Oncology (2009)

The current randomized trials comparing video-assisted thoracic surgery (VATS) lobectomy with open lobectomy for patients with early-stage non-small-cell lung cancer (NSCLC) have been of small size. We performed the present meta-analysis of the randomized and nonrandomized comparative studies in an attempt to assess the safety and efficacy of VATS lobectomy.Electronic searches identified 21 eligible comparative studies (two randomized and 19 nonrandomized) for inclusion. Two reviewers independently appraised each study. Meta-analysis was performed by combining the results of reported incidence of morbidity and mortality, recurrence, and 5-year mortality rates. The relative risk (RR) was used as a summary statistic.There were no significant statistical differences between VATS and open lobectomy in terms of postoperative prolonged air leak (P = .71), arrhythmia (P = .86), pneumonia (P = .09), and mortality (P = .49). VATS did not demonstrate any significant difference in locoregional recurrence (P = .24), as compared with the open lobectomy arm, but the data suggested a reduced systemic recurrence rate (P = .03) and an improved 5-year mortality rate of VATS (P = .04). There was no evidence to suggest heterogeneity of trial results. Fourteen studies reported VATS to open lobectomy conversion rate ranging from 0% to 15.7% (median = 8.1%).Both randomized and nonrandomized trials suggest that VATS lobectomy is an appropriate procedure for selected patients with early-stage NSCLC when compared with open surgery.
Concurrent Infectious Mononucleosis and Acute Leukemia
Authors: Melvin H. Freedman
Journal: JAMA (1970)

Despite speculation that infectious mononucleosis could be an abortive form of acute lymphatic leukemia, four children under our observation developed both diseases concurrently. Infectious mononucleosis preceded acute leukemia by three months in one case and occurred at various times during hematologic remission in the others. A review of these and five similar cases, reported previously, suggests that infectious mononucleosis is an intercurrent illness which is etiologically unrelated to acute leukemia.
Malabsorption of Hemopoietic Factors in Regional Enteritis.
Authors: Phillip B. Stott
Journal: Annals of Internal Medicine (1965)

s1 May 1965Malabsorption of Hemopoietic Factors in Regional Enteritis.Phillip B. Stott, M.D., Joseph A. Rinaldo Jr., M.D., F.A.C.P., Joseph P. Abraham, M.D. (Associate)Phillip B. Stott, M.D.Search for more papers by this author, Joseph A. Rinaldo Jr., M.D., F.A.C.P.Search for more papers by this author, Joseph P. Abraham, M.D. (Associate)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1080_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMalabsorption of hemopoietic factors is an important source of disability in regional enteritis. Six patients with established diagnoses of regional enteritis were studied in detail to elucidate this function of the small bowel. The studies included hemoglobin, white blood count, blood smear, serum iron, iron binding capacity, oral iron absorption, serum electrophoresis, bone marrow, gastric analysis, and Schilling Test as indexes of hematopoetic function; and fasting serum carotene, 4-hour urinary xylose, and 72-hour fecal fat balance as indexes of malabsorption generally.Malabsorption of a particular hemopoietic factor was closely related to the segment of small bowel involved and was not... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1080-1080KeywordsBinding analysisBlood countsBone marrowCarotenoidsDisabilitiesEnteritisFatsHematologic testsHemoglobinXylose Issue Published: 1 May 1965 PDF DownloadLoading ...
Effect of upright tilt on the phases of the cardiac cycle in normal subjects
Authors: D. H. Spodick, M. Meyer, J. R. St. Pierre
Journal: Cardiovascular Research (1971)

Non-invasive techniques were used to investigate the effects of upright tilting on the duration of cardiac cycle phases in 10 healthy male volunteers who were tilted to 70° for 7 min. All statistically significant changes occurred during the first minute, including: increases in heart rate, pre-ejection period, isovolumic contraction time, and the ratio of pre-ejection period to ejection time, and decreases in left ventricular ejection time, pulse transmission time, and the ejection time index. No significant changes occurred in electromechanical interval, pre-isovolumic contraction period, isovolumic relaxation period, and rapid filling period. Most of the statistically significant changes reflect the effects of tilt demonstrated by invasive methods. The sensitivity of non-invasive techniques to the stress of tilting provides a basis for their wider application in the evaluation of cardiocirculatory status.
A Nd:YAG laser-microperforated poly(3-hydroxybutyrate-co-3-hydroxyvalerate)-basal membrane matrix composite film as substrate for keratinocytes
Authors: Fernando Serrano, Laura López-G, Maria Jadraque, Mariëlle Koper, Gary Ellis, Pilar Cano, Margarita Martín, Leoncio Garrido
Journal: Biomaterials (2006)
Indian firm to produce oseltamivir for developing countries
Authors: Ganapati Mudur
Journal: BMJ (2006)

Roche has granted India's Hetero Drugs a sublicense for the production of the antiviral drug oseltamivir (Tamiflu) to accelerate the international stockpiling of the drug as part of influenza pandemic preparedness.

It said that the agreement would enhance supply of oseltamivir to developing countries “earlier than anticipated” and create capacity for future orders. Hetero, which is based in Hyderabad, will be able to sell oseltamivir in India …
THE ULTIMATE RESULT IN SEVERE CRANIOCEREBRAL INJURY
Authors: THEODORE T. STONE
Journal: JAMA (1927)

Our purpose in this communication is to describe in detail the sequelae and the residual signs and symptoms in a group of fifty-four cases available for examination among 101 patients who survived, out of a total group of 200 severe craniocerebral injuries admitted to the Cook County Hospital in a period of ten months, during 1924-1925.  This study includes only those cases that showed evidence of severe craniocerebral injury, skull fracture, coma, and various general or focal signs.  The material of fifty-four cases consisted of the patients who were available for examination at a period from six to eighteen months following the original injury. These patients were either visited or came to the office, and a complete physical and neurologic examination was made. In a few instances the entire material of 200 cases, including ninety-nine fatal ones, was analyzed as to the condition of the pupils, deep reflexes and spinal
Effect of maternal lorazepam on the neonate.
Authors: A G Whitelaw, A J Cummings, I R McFadyen
Journal: BMJ (1981)

Fifty-three neonates born to 51 mothers treated with lorazepam were followed up for five days after delivery. Lorazepam had been given by mouth to 35 mothers and intravenously to 16. In general, maternal plasma concentrations of lorazepam were higher than the corresponding cord plasma concentrations. Cord plasma concentrations exceeding 45 micrograms/l were associated with three-quarters of the infants requiring ventilation at birth. Neonates conjugate lorazepam slowly to the pharmacologically inactive glucuronide, which is then excreted in the urine, where it is detectable for over seven days. Though lorazepam was detectable in breast milk, the maximum amounts that an infant could absorb would be pharmacologically insignificant. Full-term neonates whose mothers had received oral lorazepam had no complications apart from slight delay in establishing feeding, which in seven out of 29 cases was associated with relatively large doses of lorazepam. Intravenous lorazepam for severe hypertension was associated with significantly low Apgar scores, need for ventilation, hypothermia, and poor suckling. Preterm babies whose mothers had been given lorazepam by either route had a high incidence of low Apgar scores, need for ventilation, hypothermia, and poor suckling. These babies had lower Apgar scores than those whose mothers had received diazepam, but the diazepam group were heavier and more mature. Lorazepam was an effective sedative and anxiolytic by either route, and there were no eclamptic fits among the lorazepam-treated patients. The effects of lorazepam on neonates indicate that its intravenous use at any stage in pregnancy and oral use before 37 weeks should be restricted to hospitals with facilities for neonatal intensive care.
Hepcidin regulation: ironing out the details
Authors: Ivana De Domenico, Diane M. Ward, Jerry Kaplan
Journal: Journal of Clinical Investigation (2007)

Hepcidin is a peptide hormone secreted by the liver that plays a central role in the regulation of iron homeostasis. Increased hepcidin levels result in anemia while decreased expression is the causative feature in most primary iron overload diseases. Mutations in hemochromatosis type 2 (HFE2), which encodes the protein hemojuvelin (HJV), result in the absence of hepcidin and an early-onset form of iron overload disease. HJV is a bone morphogenetic protein (BMP) coreceptor and HJV mutants have impaired BMP signaling. In this issue of the JCI, Babitt and colleagues show that BMPs are autocrine hormones that induce hepcidin expression (see the related article beginning on page 1933). Administration of a recombinant, soluble form of HJV decreased hepcidin expression and increased serum iron levels by mobilizing iron from splenic stores. These results demonstrate that recombinant HJV may be a useful therapeutic agent for treatment of the anemia of chronic disease, a disorder resulting from high levels of hepcidin expression.
Endothelin-1 and the Pulmonary Vascular Response to Altitude
Authors: Lewis J. Rubin
Journal: Circulation (2006)

scent to high altitude is normally associated with a modest increase in pulmonary artery pressure. 1The increased right ventricular afterload, coupled with hypobaric hypoxia-induced reductions in blood oxygen content, may lead to diminished peripheral oxygen delivery and result in dyspnea, fatigue, and exercise intolerance. 2The predominant mechanism responsible for the increase in pulmonary artery pressure at altitude is hypoxic pulmonary vasoconstriction, which is mediated through an oxygensensitive pulmonary artery smooth muscle cell voltage-gated K ϩ channel. 3The primary site of hypoxic pulmonary vasoconstriction is the small (50 to 200 m) muscular pulmonary arteries, although the pulmonary venous circuit may contribute up to 20% of the pressor response. 4A more clinically significant and potentially fatal cardiovascular consequence of exposure to altitude is the development of high-altitude pulmonary edema (HAPE).Risk factors for HAPE include gender, rate of altitude ascent, recent respiratory infection, and prior acclimatization 5 ; a genetic susceptibility also has been suggested. 6Although the mechanisms responsible for the development of HAPE remain unclear, it is associated with greater increases in pulmonary artery pressure and increased pulmonary capillary pressure, which results in hydrostatic pulmonary edema. 7The increased capillary pressure despite normal left ventricular function suggests that an exaggerated pulmonary venoconstrictor response may play a critical role.A variety of vasoactive substances are elaborated in the pressor response to altitude and in particular HAPE, including endothelin-1 (ET-1), a potent pulmonary arterial and venous constrictor. 8In this issue of Circulation, Modesti and colleagues 9 provide further evidence of the contribution of ET-1 to the pulmonary vascular responses to altitude by demonstrating that the administration of bosentan, a dual ET A and ET B receptor antagonist that is approved for the treatment of chronic pulmonary arterial hypertension, 10 attenuated the pressor response in normal subjects at altitude.
Complement profile in a Cr inhibitor deficient family
Authors: K. SAYAMA, S. SHIRAISHI, Y. MIKI
Journal: British Journal of Dermatology (1985)

Journal Article Complement profile in a Cr inhibitor deficient family Get access K. SAYAMA, K. SAYAMA Department of Dermatology, University of Ehime School of Medicine, Japan Dr K. Sayama, Department of Dermatology, University of Ehime School of Medicine, Shigenobucho, Onsengun, Ehime, 791‐02, Japan. Search for other works by this author on: Oxford Academic Google Scholar S. SHIRAISHI, S. SHIRAISHI Department of Dermatology, University of Ehime School of Medicine, Japan Search for other works by this author on: Oxford Academic Google Scholar Y. MIKI Y. MIKI Department of Dermatology, University of Ehime School of Medicine, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue 6, 1 December 1985, Pages 737–743, https://doi.org/10.1111/j.1365-2133.1985.tb02410.x Published: 01 December 1985 Article history Accepted: 03 May 1985 Published: 01 December 1985
US universities threaten to cancel subscriptions to Elsevier journals
Authors: Owen Dyer
Journal: BMJ (2004)

Several of the United State's most prestigious universities are threatening to cancel their subscriptions to scientific journals published by Elsevier, in protest at what they call exorbitant pricing. Stanford University's Faculty Senate, the latest to take action on the issue, also called on academic staff to consider placing their research in “open access” journals.

Other universities to pass similar resolutions in recent months include Harvard, Massachusetts Institute of Technology, Duke, Cornell, the University of Connecticut, the University of California, and North Carolina State University. University librarians say that journal price hikes combined with a weak dollar and falling budgets leave them no choice but to cancel subscriptions.

Michael Keller, University Librarian at Stanford, said: “It's not just that the prices have risen much …
ANCE AND SLEEP
Authors: E. LIPMAN COHEN
Journal: British Journal of Dermatology (1945)

Journal Article ANCE AND SLEEP Get access E. LIPMAN COHEN E. LIPMAN COHEN Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology and Syphilis, Volume 57, Issue 7-8, 1 July 1945, Pages 147–151, https://doi.org/10.1111/j.1365-2133.1945.tb11218.x Published: 01 July 1945
Under half of psychiatrists tell patients their diagnosis of Alzheimer's disease
Authors: R A Clafferty, K W Brown, E McCabe
Journal: BMJ (1998)

EDITOR—Patients are currently requesting more information from their doctors.1 Patients with Alzheimer's disease and those who care for them are keen to be given more information about their illness.2 The recent development of treatments for patients with the disease has highlighted this issue,3 and therefore the preliminary results of …
THE USE OF SHEET PARAFFIN IN LESIONS OF THE NOSE AND EYE.
Authors: E. MORAWECK
Journal: JAMA (1906)

Intranasal operations are for the most part simple procedures and eminently satisfactory both to the patient and to the surgeon. Sometimes following cautery work, however, removal of septal deformities, and even in some cases after turbinectomy, the postoperative swelling is a very troublesome and even serious complication, giving rise to adhesions that may leave the patient in a worse condition as regards nasal respiration than before the operation. As is well known, the reaction following operation varies greatly in different patients—the mucous membrane of some being particularly sensitive to any irritant and intolerant of operative work or even of postoperative treatment. In such individuals the liability of adhesions forming even at a period comparatively remote after operation is a serious possibility. Some cases are due to carelessness on the part of the patient or to insufficient after-treatment; this possibility, of course, is largely increased in transient patients or those from
Modulation of Statin-Activated Shedding of Alzheimer APP Ectodomain by ROCK
Authors: Steve Pedrini, Troy L Carter, George Prendergast, Suzana Petanceska, Michelle E Ehrlich, Sam Gandy
Journal: PLoS Medicine (2005)

Statins are widely used cholesterol-lowering drugs that act by inhibiting HMGCoA reductase, the rate-limiting enzyme in cholesterol biosynthesis. Recent evidence suggests that statin use may be associated with a decreased risk for Alzheimer disease, although the mechanisms underlying this apparent risk reduction are poorly understood. One popular hypothesis for statin action is related to the drugs' ability to activate alpha-secretase-type shedding of the alpha-secretase-cleaved soluble Alzheimer amyloid precursor protein ectodomain (sAPP(alpha)). Statins also inhibit the isoprenoid pathway, thereby modulating the activities of the Rho family of small GTPases-Rho A, B, and C-as well as the activities of Rac and cdc42. Rho proteins, in turn, exert many of their effects via Rho-associated protein kinases (ROCKs). Several cell-surface molecules are substrates for activated alpha-secretase-type ectodomain shedding, and regulation of shedding typically occurs via activation of protein kinase C or extracellular-signal-regulated protein kinases, or via inactivation of protein phosphatase 1 or 2A. However, the possibility that these enzymes play a role in statin-stimulated shedding has been excluded, leading us to investigate whether the Rho/ROCK1 protein phosphorylation pathway might be involved.We found that both atorvastatin and simvastatin stimulated sAPP(alpha) shedding from a neuroblastoma cell line via a subcellular mechanism apparently located upstream of endocytosis. A farnesyl transferase inhibitor also increased sAPP(alpha) shedding, as did a dominant negative form of ROCK1. Most conclusively, a constitutively active ROCK1 molecule inhibited statin-stimulated sAPP(alpha) shedding.Together, these data suggest that statins exert their effects on shedding of sAPP(alpha) from cultured cells, at least in part, by modulation of the isoprenoid pathway and ROCK1.
Outbreak of Enteritis Due to Duck Eggs
Authors: L. P. Garrod, M. B. McIlroy
Journal: BMJ (1949)

On the morning of July 7, 1949, about 40 nurses at St. Bartholomew's Hospital had reported sick with an acute febrile enteritis, and many patients throughout the wards of the hospital were similarly affected. Inquiry in the kitchen revealed that a lightly cooked pudding containing 200 duck eggs had been served to the nursing and other female staff and to patients on July 5. It was therefore no surprise when stool cultures revealed the presence of Salmonella typhi-murium. The outbreak was on an exceptional scale for one so produced, and had features which appear worthy of record. Source of Infection
THE MAMMARY AND THE PAROTID GLANDS.
Authors: JOHN B. SHOBER
Journal: JAMA (1900)

I deeply appreciate the honor you have conferred upon me by your invitation to take part in this symposium. I have been asked to say a few words in regard to the therapeutic value of the mammary and the parotid glands in certain morbid conditions of the female pelvic organs. Upon the receipt of the invitation, my first impulse was to decline, because, although my clinical experience has greatly increased since the publication of my last paper on this subject, I felt that I had nothing new to say at this time. Upon further reflection, however, I decided to embrace the opportunity in order to point out and emphasize how these agents should not be used. I have always tried to be very clear in my statements as to the precise indications which in my experience call for their use, and yet I find that physicians all over the country
Genetic modifiers of sickle cell disease
Authors: Martin H. Steinberg, Paola Sebastiani
Journal: American Journal of Hematology (2012)

Abstract Sickle cell anemia is associated with unusual clinical heterogeneity for a Mendelian disorder. Fetal hemoglobin concentration and coincident α thalassemia, both which directly affect the sickle erythrocyte, are the major modulators of the phenotype of disease. Understanding the genetics underlying the heritable subphenotypes of sickle cell anemia would be prognostically useful, could inform personalized therapeutics, and might help the discovery of new “druggable” pathophysiologic targets. Genotype‐phenotype association studies have been used to identify novel genetic modifiers. In the future, whole genome sequencing with its promise of discovering hitherto unsuspected variants could add to our understanding of the genetic modifiers of this disease. Am. J. Hematol. 2012. © 2012 Wiley Periodicals, Inc.