tbuckley/cabot-search huggingface dataset:
Photochemical internalisation of a macromolecular protein toxin using a cell penetrating peptide-photosensitiser conjugate
Authors: Julie T.-W. Wang, Francesca Giuntini, Ian M. Eggleston, Stephen G. Bown, Alexander J. MacRobert
Journal: Journal of Controlled Release (2011)

Photochemical internalisation (PCI) is a site-specific technique for improving cellular delivery of macromolecular drugs. In this study, a cell penetrating peptide, containing the core HIV-1 Tat 48-57 sequence, conjugated with a porphyrin photosensitiser has been shown to be effective for PCI. Herein we report an investigation of the photophysical and photobiological properties of a water soluble bioconjugate of the cationic Tat peptide with a hydrophobic tetraphenylporphyrin derivative. The cellular uptake and localisation of the amphiphilic bioconjugate was examined in the HN5 human head and neck squamous cell carcinoma cell line. Efficient cellular uptake and localisation in endo/lysosomal vesicles was found using fluorescence detection, and light-induced, rupture of the vesicles resulting in a more diffuse intracellular fluorescence distribution was observed. Conjugation of the Tat sequence with a hydrophobic porphyrin thus enables cellular delivery of an amphiphilic photosensitiser which can then localise in endo/lysosomal membranes, as required for effective PCI treatment. PCI efficacy was tested in combination with a protein toxin, saporin, and a significant reduction in cell viability was measured versus saporin or photosensitiser treatment alone. This study demonstrates that the cell penetrating peptide-photosensitiser bioconjugation strategy is a promising and versatile approach for enhancing the therapeutic potential of bioactive agents through photochemical internalisation.
The heat-stable antigen can alter very late antigen 4-mediated adhesion.
Authors: M Hahne, R H Wenger, D Vestweber, P J Nielsen
Journal: The Journal of Experimental Medicine (1994)

The integrin very late antigen, (VLA-4) alpha 4 beta 1 and its counter receptor vascular cell adhesion molecule 1 (VCAM-1) are involved in B cell maturation and pre-B cell attachment to bone marrow stroma cells. We have analyzed whether heat-stable antigen (HSA), a marker for immature leukocytes, is involved in such cell adhesion phenomena. HSA is a glycolipid-anchored, highly glycosylated surface protein differentially expressed on cells during the maturation of both the hematopoietic and nervous systems. We found that pre-B cells lacking HSA (due to targeted disruption of both alleles) can still bind via VLA-4 to tumor necrosis factor alpha-stimulated endothelioma cells. This binding, however, cannot be blocked by an anti-VCAM-1 antibody. Restoration of HSA expression restores the inhibitable VCAM-1 binding. We also found that pre-B cells lacking HSA did not bind to the FN40 fragment of fibronectin but reexpression of HSA restored VLA-4-mediated binding to fibronectin. Thus, expression of HSA on pre-B cells modifies the binding specificity of VLA-4 for two known ligands.
Mitral disc-valve variance
Authors: R. B. Berroya, F. B. Escano
Journal: Thorax (1972)

This report deals with a rare complication of disc-valve prosthesis in the mitral area. A significant disc poppet and struts destruction of mitral Beall valve prostheses occurred 20 and 17 months after implantation. The resulting valve incompetence in the first case contributed to the death of the patient. The durability of Teflon prosthetic valves appears to be in question and this type of valve probably will be unacceptable if there is an increasing number of disc-valve variance in the future.
Are Anti-inflammatory Therapies Viable Treatments for Psychiatric Disorders?
Authors: Andrew H. Miller, Charles L. Raison
Journal: JAMA Psychiatry (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Vitamin D Modulates Immune Defense Molecules in Patients with Chronic Rhinosinusitis
Authors: S. Watanabe, X. Jiang, S. Sharma, J. Lane, M. DeTineo, T. Muninopasa, M. Bashir, N. Joyner, F.M. Baroody, R.M. Naclerio, J.M. Pinto
Journal: Journal of Allergy and Clinical Immunology (2012)
Adverse Effects Associated With Transcatheter Aortic Valve Implantation
Authors: Prateek J. Khatri, John G. Webb, Josep Rodés-Cabau, Stephen E. Fremes, Marc Ruel, Kelly Lau, Helen Guo, Harindra C. Wijeysundera, Dennis T. Ko
Journal: Annals of Internal Medicine (2013)

Background: Transcatheter aortic valve implantation (TAVI) has emerged as an important treatment for patients with severe symptomatic aortic stenosis who are at high operative risk, but accurate estimates of serious adverse effects in contemporary practice are not available. Purpose: To quantify the adverse effects associated with TAVI, and to evaluate whether the type of transcatheter valve and the route of valve implantation are associated with differences in adverse outcomes. Data Source: PubMed to 5 May 2012. Study Selection: All studies that included at least 100 patients who had TAVI and reported at least 1 outcome of interest. Data Extraction: Two reviewers abstracted the data independently. A random-effects model was used to combine data on adverse outcomes and conduct stratified analyses. Data Synthesis: A total of 49 studies enrolling 16 063 patients met the inclusion criteria. Overall 30-day and 1-year survival after TAVI were 91.9% (95% CI, 91.1% to 92.8%) and 79.2% (CI, 76.9% to 81.4%), respectively. Heart block requiring permanent pacemaker implantation was the most common adverse outcome (13.1%) and was 5 times more common with the CoreValve (Medtronic, Minneapolis, Minnesota) than the Sapien valve (Edwards Lifesciences, Irving, California) implanted using the transarterial route (25.2% vs. 5.0%, respectively). The overall rate of vascular complications was 10.4% and was highest with transarterial implantation of the Sapien valve (22.3%). Acute renal failure requiring renal replacement therapy was the third most common complication, occurring in 4.9% of patients. Limitation: Rates of major vascular complications may be overestimated owing to rapidly evolving TAVI technology. Conclusion: The most common adverse effects associated with TAVI are heart block, vascular complications, and renal failure. The type of transcatheter valve and the route of implantation are associated with observed variations in the risks for some adverse effects. Primary Funding Source: Heart and Stroke Foundation of Canada.
Neonatal Gynecomastia Visualized During Tc-99m Pertechnetate Thyroid Scintigraphy
Authors: Saleh Othman, Mahmoud El-Desouki
Journal: Clinical Nuclear Medicine (2003)

A 4-day-old male infant with an elevated serum thyroid stimulating hormone level was referred for a thyroid scan as part of the investigation for possible hypothyroidism. The thyroid scan using Tc-99m pertechnetate showed a normally located but enlarged thyroid gland with normal uptake. In addition, the scan revealed 2 focal areas of increased uptake in the breast regions compatible with bilateral breast enlargement (gynecomastia). Neonatal gynecomastia is the result of transplacental passage of maternal and/or placental estrogen and may be associated with nipple discharge known as witch's milk. It usually resolves during the first few weeks of life.
Car allowance for consultants
Authors: J. A N Emslie
Journal: BMJ (1977)

<h3>Objective</h3> To assess the role of CSF chitinase 3-like-1 (CHI3L1), chitinase 3-like-2 (CHI3L2), and neurofilament light chain (NfL) in predicting the course of primary progressive MS (PPMS). <h3>Methods</h3> We analyzed CSF CHI3L1, CHI3L2, and NfL levels in 25 patients with PPMS with disease duration ≤10 years and no disease-modifying therapy for ≥6 months from the prospective Understanding Primary Progressive Multiple Sclerosis cohort study. CSF samples taken at disease diagnosis were analyzed using commercial ELISAs and following the manufacturer9s instructions. Data on Expanded Disability Status Scale (EDSS) scores, disability progression, and cognitive function according to the Brief Repeatable Neuropsychological Battery were also assessed throughout the 1-year study follow-up. <h3>Results</h3> Increasing CHI3L1 levels correlated with higher EDSS scores at baseline (ρ = 0.490, 95% CI 0.118–0.742, <i>p</i> = 0.013) and month 12 (ρ = 0.455, 95% CI 0.063–0.725, <i>p</i> = 0.026) and tended to be associated with a higher risk of disability progression according to EDSS scores (OR = 1.008, 95% CI 0.999–1.017, <i>p</i> = 0.089). Increasing CHI3L2 levels also tended to correlate with lower baseline EDSS scores (ρ = −0.366, 95% CI -0.676–0.054, <i>p</i> = 0.086). There was no correlation with regard to NfL levels. <h3>Conclusions</h3> This analysis supports the association between CSF CHI3L1 levels and neurologic disability according to EDSS scores in patients with PPMS. Other chitinase-like proteins such as CHI3L2 may also be involved. <h3>Classification of evidence</h3> This study provides Class II evidence that CSF CHI3L1 is associated with neurologic disability in patients with PPMS.
ALOPECIA AND SEBORRHEA
Authors: CHARLES J. WHITE
Journal: JAMA (1910)

Dandruff and loss of hair are two of the minor afflic- tions of civilized life which are usually sources of con- stant chagrin to the unfortunate men and women who fall victims to their presence.One or both of these con- ditions, which even we ourselves experience sooner or later, are brought to our attention as dermatologists so frequently that it seems fitting from time to time to present them as themes for discussion when we meet in the hope that some member here may contribute some small bit of knowledge to a subject which needs so much help from an etiologic and therapeutic stand\x=req\ point.It is, therefore, because we practitioners are usually so helpless when confronted by a well-estab- lished case of alopecia or of seborrhea that I have ven- tured to summarize my knowledge of these conditions gleaned from the study of 794 examples observed in my personal private practice.In the following pages I shall deal principally with seborrhea capitis and with alopecia simplex and alopecia furfuracea, but I shall speak superficially on alope- cia areata, and alopecia from ringworm, syphilis and overexposure to x-rays.ALOPECIA Statistically, I record 679 cases of loss of hair divided clinically as follows : CasesMales Females Alopecia simplex1 ...
Medical Intelligence
Authors: David H. Baker, Richard E. Wilson
Journal: JAMA (1963)

SINCE LISTER first used boric acid as an antiseptic in 1875, the therapeutic powers of this agent have been questioned frequently by many investigators. Despite overwhelming evidence that the antiseptic and healing value of boron compounds barely exceed those of distilled water, cases of iatrogenic boric acid poisoning continue to occur. The following patient treated at Peter Bent Brigham Hospital will serve as an example. <h3>Report of a Case</h3> A 14-year-old schoolboy had suffered a 12% second and third degree burn of his left lower extremity while playing with a blowtorch in the presence of gasoline five weeks prior to his admission. The burned area was treated in another hospital with 1% boric acid soaks two to three times each day from the time of the accident until his transfer. The patient appeared to be recovering well with healthy granulation tissue on the leg and grafting was being contemplated when
Who Benefits From Medical Savings Accounts?-Reply
Authors: Emmett B. Keeler
Journal: JAMA (1996)

In Reply.  —Putting the patient in charge, as Dr Guazzo recommends, may be a good idea, but to make socially optimal decisions, patients need to face the full costs of care. The implicit tax subsidy to MSA savings and the reasonable chance (20%-37%) of exceeding the catastrophic deductible prevents this. If we could limit the tax subsidies of health insurance, people would have more incentive to choose plans in which they paid a higher percentage of the costs of care.  Dr Kastner and colleagues assert that consumers will choose the plan with the lowest out-of-pocket cost. If so, their figure implies that healthy people should choose FFS and that sicker people should choose HMOs. In fact, HMO enrollees are healthier than those remaining in FFS. 1 Our model of choice was based on many factors besides out-of-pocket payments and assumed the value of choice of physician and of amount of treatment is
A green oral appliance
Authors: C. Mermigkis, K. Psathakis, P. Panagou
Journal: European Respiratory Journal (2008)

A green oral applianceTo the Editors:A patient presented with an oral appliance (OA) that was coated in a green residue (fig.1).This has never been seen before in our sleep department, which has managed over 100 patients with OAs for snoring and mild obstructive sleep apnoea (OSA).
Accumulating Evidence for Prenatal Nutritional Origins of Mental Disorders
Authors: Richard Neugebauer
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Peroperative transduodenal biopsy of the pancreas.
Authors: D E Tweedle
Journal: Gut (1979)

Peroperative transduodenal biopsy of the pancreas was performed in 65 patients with the disposable Trucut needle. The technique described is simple, effective, and may reveal unsuspected malignancy. A histological diagnosis of malignancy is reliable but false negative diagnosis may arise because of failure to obtain representative samples.
Angiographic Evidence of Coronary-Subclavian Steal Syndrome
Authors: C.R. Kroll, M. Agarwal, G.A. Stouffer
Journal: Circulation (2002)

A 49-year-old man who had undergone coronary artery bypass grafting 16 months earlier presented with complaints of increasing angina pectoris.Initial angiography of the left coronary artery showed that contrast dye went retrograde up the left internal mammary artery (LIMA) and into the subclavian artery (Figure ,A).Competitive flow was observed in the chest wall branches of the LIMA.Angiography demonstrated a severe obstruction of the left subclavian artery (Figure, B) with poor opacification of the artery distal to the stenosis and minimal appearance of contrast dye in the vertebral artery or LIMA.After stent placement (Figure, C), the subclavian artery, vertebral artery, and LIMA were all opacified by antegrade flow.This case demonstrates angiographic evidence of flow from the coronary system into the subclavian artery and supports prior reports of the existence of coronary-subclavian steal syndrome in patients with LIMA grafts and subclavian disease.A, Angiography of the left coronary artery and LIMA in a right anterior oblique cranial projection.The figure is a composite of 2 images obtained during the same injection.The arrow points to the subclavian artery.B, Angiography of the left subclavian artery in an anterior-posterior projection.C, Angiography of the left subclavian artery in an anterior-posterior projection after stent placement.Vert indicates vertebral artery.
Tests in Cushing's Syndrome
Authors: MURRAY J. FAVUS
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 May 1970Tests in Cushing's SyndromeMURRAY J. FAVUS, M.D.MURRAY J. FAVUS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-758 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their article "Evaluation of Stimulation and Suppression Tests in the Etiological Diagnosis of Cushing's Syndrome" (Ann Intern Med 71:941-949, 1969) the authors have included some data that I hope they will clarify.In describing the response to the high-dose dexamethasone test, the authors state that all patients but one with adrenal hyperplasia suppressed to below 50% of the base-line value. In their data in Table 1 it appears that both Patient E.B. and Patient M.T. failed to meet the criteria for suppression.There was no mention of the normal range of adrenocorticotrophic hormone (ACTH) by their...Reference1. DRUCKERROGINSKYCHRISTY WMN: Persistence of abnormal pituitary-adrenal relationship in patients with Cushing's disease partially corrected by bilateral subtotal adrenalectomy. Amer J Med 38:522, 1965 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MURRAY J. FAVUS, M.D.Affiliations: 12000 Fairhill Road Cleveland, Ohio 44120 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCushing's syndrome: A review of diagnostic tests 1 May 1970Volume 72, Issue 5Page: 758-759KeywordsAdrenocorticotropic hormoneDexamethasone suppression test ePublished: 1 December 2008 Issue Published: 1 May 1970 PDF downloadLoading ...
Warning of Massive Pulmonary Embolism
Authors: D. Negus
Journal: BMJ (1967)

MBROIBi= 559 instances of subarachnoid haemorrhage and of unexplained deaths.This case, which will be presented in detail, supports Mr. Barabas's contention that there may exist an "arterial" type of syndrome.It provides a particularly florid example, with a similar illness occurring in milder form in a brother.Although usually regarded as an autosomal dominant trait,' the possibility of different modes of inheritance in a heterogeneous syndrome has always to be considered, and one might speculate that some cases of the " arterial " form might be transmitted as autosomal recessives.If this were so parents would not be expected to show the trait, and absence of family history could be compatible with this mode of inherit- ance, as in the case of Rubinstein and Cohen,2 another of our own,3 and number 27 of Barabas.The features of systemic illness (fever, etc.) ink our patient are not well explained and it may be noteworthy that they had occurred in milder form earlier in this patient's his- tory.We wonder whether others have had similar experiences and whether more acute episodes of arterial damage may occur in the course of Ehlers-Danlos syndrome.-Weare, etc.,
THE ASSOCIATION OF HUMAN RESISTIN AND CARDIOVASCULAR DISEASE IN THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA)
Authors: Evan D. Muse, Michael J. Blaha, Rajesh Tota-Maharaj, Matthew J. Budoff, Kurrham Nasir, Michael H. Criqui, Mary Cushman, Robyn L. McClelland, Roger S. Blumenthal, Matthew A. Allison
Journal: Journal of the American College of Cardiology (2013)
Orthopaedic Management in Cerebral Palsy
Authors: James J. McCarthy
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Calcification in a Benign, Nonfunctioning Tumor of the Adrenal
Authors: William D. Drucker
Journal: JAMA (1961)

CALCIFICATION in a suprarenal mass is generally evidence of a malignant tumor of the adrenal. Few exceptions to this are recorded in the literature. McAfee and Balli<sup>1</sup>cite 2 instances of cyst-like calcified adenomas, and the occasional occurrence of calcification in teratomas which may or may not show malignant change.<sup>2</sup>McAfee and Balli also gathered several reports of pheochromocytoma with radiologically detectable calcium.<sup>1</sup>Although this lesion is only rarely malignant, the consequences of its presence and the risks of surgical removal may be serious. Boice and Sears<sup>3</sup>could find only 2 references to calcification occurring in a benign neoplasm of the adrenal—one purported to be a primary psammoma; the other, a pheochromocytoma. A review by Bachman<sup>4</sup>calls attention to one other benign tumor, the histology of which was undetermined. Calcification of one or both adrenals in Addison's disease associated with tuberculosis or histoplasmosis is well
Red cell values on the first postnatal day during the last 16 weeks of gestation
Authors: Rina Zaizov, Yehuda Matoth
Journal: American Journal of Hematology (1976)

The hemoglobin concentration, red cell count, hematocrit, reticulocyte count, and red cell size distribution were determined on skin prick blood obtained on the first postnatal day from infants born at various stages of gestation, from week 24 to term. During this period the hemoglobin concentration and hematocrit remained constant, around 19 gm/100 ml and 60%, respectively. The mean corpuscular volume decreased progressively, with a corresponding rise in the red cell count. The reticulocyte count decreased progressively from 9.6% to 3.7% during the period of observation. The red cell size distribution (Price Jones) curve was markedly shifted to the macrocytic side at 24-25 weeks. Thereafter, cells larger than 102 mu3 decreased gradually, while the percentage of smaller cells increased. These observations are not consistent with the hypothesis of a progressive decrease in the supply of oxygen to the fetus during the later stages of gestation, to which the fetus adapts by increasing its hemoglobin concentration.