tbuckley/cabot-search huggingface dataset:
Outcomes of Patients With Acute Coronary Syndromes and Prior Coronary Artery Bypass Grafting
Authors: Marino Labinaz, Rakhi Kilaru, Karen Pieper, Steven P. Marso, Michael M. Kitt, Maarten L. Simoons, Robert M. Califf, Eric J. Topol, Paul W. Armstrong, Robert A. Harrington
Journal: Circulation (2002)

Background — Patients with prior CABG with a subsequent non–ST-segment elevation acute coronary syndrome (ACS) pose an increasingly important clinical problem. Although GP IIb/IIIa inhibitors have improved the outcome of patients with ACS, their efficacy in patients with prior CABG has not been previously evaluated. Methods and Results — We analyzed the 30- and 180-day outcomes of patients with prior CABG enrolled in the Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy (PURSUIT) trial. In this trial, which evaluated the efficacy of eptifibatide in patients with ACS, 1134 patients (12%) with prior CABG and 8321 without prior CABG were enrolled. After adjusting for differences in baseline characteristics and treatment, patients with prior CABG had a significantly higher mortality rates at 30 days (hazard ratio [HR], 1.45 [95% CI, 1.06 to 1.98]; P =0.019) and at 180 days (HR, 1.32 [95% CI, 1.04 to 1.67]; P =0.021). At 30 days, there was a similar effect on the primary end point of death or myocardial infarction in the eptifibatide group versus the placebo group in prior CABG patients (unadjusted HR, 0.90 [95% CI, 0.67 to 1.20]) and in patients without a history of CABG (unadjusted HR, 0.89 [95% CI, 0.80 to 0.99]). Conclusions — Patients with prior CABG with non–ST-segment elevation ACS have a significantly worse prognosis than do patients without a history of CABG. The treatment effect of eptifibatide in the prior CABG group was similar to the effect seen in patients without prior CABG.
Intravenous antimicrobial therapy in the community: underused, inadequately resourced, or irrelevant to health care in Britain?
Authors: D. Nathwani, P. Davey
Journal: BMJ (1996)

The NHS Executive is keen to promote "hospital at home" services in Britain, as part of its philosophy of keeping more care in the community and also to relieve the increasing demand for hospital beds. One such service is the provision of intravenous antimicrobial therapy in the community. Yet, compared with the United States, where home or outpatient intravenous antimicrobial therapy programmes are well developed, experience in Britain and Europe is limited, reflecting a difference in cultural attitudes and healthcare structures between the two continents. Only a few units in Britain currently run home intravenous antimicrobial therapy programmes, and several issues need to be addressed if more treatment is to be provided outside hospital. These include an assessment of the need for community intravenous antibiotic treatment and which patient groups many benefit. The main motive for community intravenous treatment should be better patient care and not simply a reduction in healthcare costs. At present the pace of change is being set by a few clinical enthusiasts and by commercial organisations, whereas the NHS deserves a more organised strategy for purchasing treatment with intravenous antibiotics in the community.
Successful Surgical Interruption of the Bundle of Kent in a Patient with Wolff-Parkinson-White Syndrome
Authors: FREDERICK R. COBB, SARAH D. BLUMENSCHEIN, WILL C. SEALY, JOHN P. BOINEAU, GALEN S. WAGNER, ANDREW G. WALLACE
Journal: Circulation (1968)

Recurrent supraventricular tachycardia is a frequent complication in patients with the Wolff-Parkinson-White (WPW) syndrome. Our patient was unusual in that the arrhythmia was the predominant rhythm, and it was felt that the sustained tachycardia was responsible for signs and symptoms of congestive heart failure. The arrhythmia could not be controlled adequately with digitalis, quinidine, diphenylhydantoin, or propranolol. Atrial or ventricular pacing also failed to prevent recurrent episodes of tachycardia. Physiological and pharmacological studies suggested that an anomalous pathway was responsible for the WPW abnormality and participated in a re-entrant circuit which sustained the episodes of tachycardia. Isopotential body surface mapping suggested anomalous ventricular excitation at the lateral aspect of the right atrioventricular groove. Epicardial mapping at the time of surgery was used to localize the earliest area of anomalous ventricular activation, and surgical transection of the atrioventricular junction at that point abolished the electrocardiographic features of WPW and the recurrent tachycardia. Five months after surgery neither the ECG features of WPW nor the tachycardia has recurred. The signs and symptoms of congestive heart failure have subsided, and the patient has returned to work.
TRAUMATISMS AND MALFORMATIONS OF THE FEMALE GENITAL APPARATUS, AND THEIR RELATION TO INSANITY.
Authors: GEORGE HENRY NOBLE
Journal: JAMA (1900)

In writing this paper it occurred to me that instead of using the small amount of evidence in my possession to emphasize facts already adduced, an expression of opinion by the alienists and gynecologists of this country and an analysis of their views might aid in reaching a true consensus of medical opinion upon the subject. Accordingly I addressed a number of letters to the superintendents of insane asylums in the United States, and to the members of two of the most prominent gynecological societies, in which I requested replies to the following questions: Do you regard malformations and traumatisms of the female genital apparatus as causes of insanity? If so, in what per cent. of this class of cases, in whom physical examinations of the genitals have been made with the view of ascertaining the facts, can insanity be ascribed to these causes? Please state character of malformations and
623. Polymer Microparticles Delivering a Idiotype/Chemokine Fusion DNA Vaccine Generate Protective Immunity in a Mice Model of B Cell Lymphoma
Authors: Sudhir P. Kasturi, Bilal Ghosn, Kassandra S. Thomson, Hong Qin, Larry Kwak, Krishnendu Roy
Journal: Molecular Therapy (2006)

Top of pageAbstract
Introduction:

We earlier demonstrated that branched Polyethyleneimine (PEI) conjugated poly(lactide-co-glycolide)PLGA microparticles enhanced transfection in phagocytic RAW cells in vitro.1 We present herecomparison of the effects of linear and branched PEI conjugated PLGA microparticles in enhancing the potential of a model idiotype/chemokine fusion encoding genetic vaccine for B cell lymphoma in mice models. Branched PEI70kDa polymer conjugated PLGA microparticles in comparison with linear PEI conjugated microparticles; a) better adsorbed plasmid DNA b) showed significant adjuvant effects by upregulating MHC class II and CD80 molecules in macrophage cells and finally c) demonstrated enhanced anti tumor effects upon challenge with an A20 B cell lymphoma tumor in Balb/C mice in vivo. Branched PEI70kDa conjugated PLGA microparticles imparted anti tumor effects which were comparable or slightly better than gene gun mediated immunization, especially when administered intramuscularly.

Materials and Methods:

Synthesis of cationic microparticles and characterization was performed as described earlier1. FACS studies were conducted using fluorescent antibodies such as MHC class II, CD80, F4/80 (Ebiosciences, CA) were used to stain RAW264.7 murine macrophage cells (ATCC, VA) post formulation stimulation. Balb/c mice 8-10 weeks old were injected 3 times with cationic microparticles and with gene gun based approaches. A20 tumors were injected at 2.5 times the minimal lethal dose. Survival rates of mice (anti tumor effects) were followed and plotted to confirm statistical significance.

Results and Discussion:

Plasmid DNA adsorbed on 70kDa branched PEI modified PLGA microparticles demonstrated significant upregulation of MHC class II and CD80 molecules in RAW macrophage cell lines in vitro. These results were also consistent with potent anti tumor effects in vivo. Intramuscular injections of cationic microparticles with adsorbed vaccine encoding plasmid DNA demonstrated anti tumor effects which were comparable with long established gene gun based approaches. Intramuscular injections of cationic particle based formulation proved to be superior to intradermal injections.

Conclusions:

Cationic PEI conjugated PLGA microparticles could offer an attractive strategy to enhance the immunogenecity of weak self antigens encoded by cancer DNA vaccines. We hypothesize that these alternative approaches with injectable formulations offer more flexibility in terms of introducing additional adjuvants such as synthetic MPL-A and CpG optimized oligos which could significantly further enhance the potential of these cancer genetic vaccines. Current studies are underway to test these enhanced anti tumor effects by co-administration of soluble adjuvants.
Expression of estrogen receptors in cholangiocytes of patients with primary biliary cirrhosis (PBC) and relationship with immunohistochemical markers of cell proliferation and death
Authors: D. Alvaro, P. Invernizzi, P. Onori, A. Franchitto, G. Pinto, A. De Santis, M.G. Mancino, A.F. Attili, M. Podda, E. Gaudio
Journal: Journal of Hepatology (2003)
Plasma concentrations and tissue uptake of free amino acids in dogs in sepsis and starvation: Effects of glucose infusion — Some effects of low alimentation
Authors: Neelakanthan Vaidyanath, Ronald Birkhahn, John R. Border, Garret Oswald, Gregory Trietley, None Tran Fu Yuan, Erich Moritz, Rapier H. McMenamy
Journal: Metabolism (1978)
Efficacy and tolerability of piperacillin/tazobactam versus ceftazidime in association with amikacin for treating nosocomial pneumonia in intensive care patients: a prospective randomized multicenter trial
Authors: F. Álvarez-Lerma, J. Insausti-Ordeñana, R. Jordá-Marcos, E. Maraví-Poma, A. Torres-Martí, J. Nava, A. Martínez-Pellús, M. Palomar, F. Barcenilla and the Spanish Collabor
Journal: Intensive Care Medicine (2001)
Lipid peroxidation and hepatic antioxidants in alcoholic liver disease.
Authors: R D Situnayake, B J Crump, D I Thurnham, J A Davies, J Gearty, M Davis
Journal: Gut (1990)

The generation of hepatic liver peroxidation by free radicals has been proposed as a mechanism for ethanol induced hepatotoxicity. To investigate this hypothesis, lipid extracts from hepatic needle biopsy specimens from alcoholic subjects were examined for evidence of lipid peroxidation by measuring total conjugated dienes by derivative spectroscopy and, after hydrolysis of hepatic lipid extract and reverse phase high performance liquid chromatography, the molar ratio between a diene-conjugated linoleic acid isomer (18:2 (9,11)) and the parent linoleic acid isomer (18:2(9,12)). Changes were related to hepatic histology, iron deposition, glutathione and vitamin E values. Derivative spectroscopy minima suggestive of diene conjugation were identified at 233 and 242 nm and correlated weakly, suggesting these two minima may represent different classes of lipid dienes. There was a weak relation with inflammatory histological changes in the biopsy specimen but no correlation with hepatic iron grade, glutathione, or vitamin E lipid ratio. The proportion of 18:2(9,11) linoleic acid in hepatic lipids correlated significantly with inflammatory histological features and inversely with hepatic glutathione. Furthermore, hepatic glutathione was lower in biopsy specimens with greater iron staining. The ratio of vitamin E to lipid was not related to histological group, inflammation, or iron grade. These findings suggest that excess alcohol consumption leads to hepatic inflammation and lipid peroxidation.
The Kidney Connection
Authors: David M. Safley, Adnan K. Chhatriwalla
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Does stress echocardiography predict the site of future myocardial infarction? A large-scale multicenter study
Authors: Albert Varga, Eugenio Picano, Lauro Cortigiani, Nunzia Petix, Franca Margaria, Ornella Magaia, Joanna Heyman, Riccardo Bigi, Wilson Mathias, Guido Gigli, Patrizia Landi, Mauro Raciti, Alessandro Pingitore, Rosa Sicari
Journal: Journal of the American College of Cardiology (1996)
Refugee doctors can do valuable work in European host countries
Authors: T. Wenzel
Journal: BMJ (1999)

EDITOR—In their editorial Berlin et al emphasised the importance of finding new approaches to integrate medical doctors living as refugees in European host countries.1 In a project developed during the war in neighbouring Yugoslavia, the Austrian Board of Psychotherapy set up a pilot training programme for doctors and psychologists from Bosnia-Hercegovina who had been forced to flee the country. Participants underwent two years …
Ethical Issues in Umbilical Cord Blood Banking
Authors: Jeremy Sugarman
Journal: JAMA (1997)

<h3>Objective.</h3> —Banking umbilical cord blood (UCB) to be used as a source of stem cells for transplantation is associated with a set of ethical issues. An examination of these issues is needed to inform public policy and to raise the awareness of prospective parents, clinicians, and investigators. <h3>Participants.</h3> —Individuals with expertise in anthropology, blood banking, bone marrow transplantation, ethics, law, obstetrics, pediatrics, and the social sciences were invited to join the Working Group on Ethical Issues in Umbilical Cord Blood Banking. <h3>Evidence.</h3> —Members were assigned topics to present to the Working Group. Following independent reviews, background materials were sent to the Working Group. <h3>Consensus Process.</h3> —Individual presentations of topics at a 2-day meeting were followed by extensive group discussions in which consensus emerged. A writing committee then drafted a document that was circulated to the entire Working Group. After 3 rounds of comments over several months, all but 1 member of the Working Group agreed with the presentation of our conclusions. <h3>Conclusions.</h3> —(1) Umbilical cord blood technology is promising although it has several investigational aspects; (2) during this investigational phase, secure linkage should be maintained of stored UCB to the identity of the donor; (3) UCB banking for autologous use is associated with even greater uncertainty than banking for allogeneic use; (4) marketing practices for UCB banking in the private sector need close attention; (5) more data are needed to ensure that recruitment for banking and use of UCB are equitable; and (6) the process of obtaining informed consent for collection of UCB should begin before labor and delivery.
Management of ulcerated necrobiosis lipoidica: an innovative approach
Authors: L. Stuart, P.G. Wiles
Journal: British Journal of Dermatology (2001)

Journal Article Management of ulcerated necrobiosis lipoidica: an innovative approach Get access L. Stuart, L. Stuart Directorate of Podiatry University of Salford *Diabetes Centre, North Manchester Health Care Trust, Manchester, UK. Correspondence: Louise Stuart.E‐mail: l.stuart@salford.ac.uk Search for other works by this author on: Oxford Academic Google Scholar P.G. Wiles P.G. Wiles Directorate of Podiatry University of Salford *Diabetes Centre, North Manchester Health Care Trust, Manchester, UK. Correspondence: Louise Stuart.E‐mail: l.stuart@salford.ac.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 144, Issue 4, 1 April 2001, Pages 907–909, https://doi.org/10.1046/j.1365-2133.2001.04160.x Published: 01 April 2001
Naturally Formed Coronary Arterial Thrombus Detected by In-111 Oxine Platelet Imaging
Authors: Chunlei Zhao, Noriyuki Shuke, Atsutaka Okizaki, Wakako Yamamoto, Junichi Sato, Kunihiro Iwata, Takayasu Kanno, Naoyuki Hasebe, Kenjiro Kikuchi, Tamio Aburano
Journal: Clinical Nuclear Medicine (2005)

A 56-year-old man with acute myocardial infarction of the inferior wall was treated with thrombolytic therapy during emergency coronary angiography. Ten days later, In-111 oxine platelet imaging was performed using a hybrid single-photon emission computed tomography (SPECT)/computed tomography (CT) scanner and a continuous abnormal uptake was detected in the trunk of the right coronary artery (RCA). Thin-slice thoracic contrast-enhanced CT verified that the accumulation corresponded to the remaining thrombus in the dilated RCA. This case highlights the usefulness of In-111 oxine platelet imaging for detecting a coronary arterial thrombus. The value of hybrid SPECT/CT imaging for its correct localization is also stressed.
The Feasibility of Automated Voice Messaging as an Adjunct to Diabetes Outpatient Care
Authors: John D Piette, Connie A Mah
Journal: Diabetes Care (1997)

OBJECTIVE To determine whether automated voice messaging (AVM) systems could be used as an adjunct to primary care for diabetic patients, we examined whether patients were able to respond to AVM queries for clinical information, whether sufficient numbers of problems were identified to warrant the implementation of the service, and whether patients found the system helpful. RESEARCH DESIGN AND METHODS The AVM system we examined uses specialized computer technology to telephone patients, communicate messages, and collect information. Sixty-five diabetic patients participated. Based on a review of the literature and the input of diabetes clinician-researchers, we developed an AVM monitoring protocol to inquire about patients’ symptoms, glucose monitoring, foot care, diet, and medication adherence. Patients also were given the option to listen to health promotion messages and to report their satisfaction with the calls. Patients responded by using their touch-tone telephone keypads. RESULTS A total of 216 AVM calls were successfully completed, an average of 3.3 out of four calls per patient. Patients reported a variety of health problems that signaled the need for follow-up. Many patients reported not checking their blood glucose or their feet, and one in four reported problems with medication and diet adherence. Health and self-care problems varied across patient subgroups in ways suggesting that the AVM reports were reliable and valid. Overall, 98% of all patients reported that the calls were helpful, 98% reported that they had no difficulty responding to the calls, and 77% reported that receiving AVM calls would make them more satisfied with their health care. CONCLUSIONS This study demonstrates that diabetic patients can respond to AVM queries and find the calls helpful. Such calls are a feasible strategy for identifying health and self-care problems that would otherwise go unnoticed by clinicians.
The effect of stromal cell-derived factor-1α/heparin coating of biodegradable vascular grafts on the recruitment of both endothelial and smooth muscle progenitor cells for accelerated regeneration
Authors: Jian Yu, Aijun Wang, Zhenyu Tang, Jeffrey Henry, Benjamin Li-Ping Lee, Yiqian Zhu, Failei Yuan, Fengping Huang, Song Li
Journal: Biomaterials (2012)
BEHAVIORAL EVALUATION OF IMIPRAMINE AND NIALAMIDE IN REGRESSED SCHIZOPHRENIC PATIENTS WITH DEPRESSIVE FEATURES
Authors: CARL A. LEUTHOLD, F. J. BRADSHAW, G. W. ARNDT, E. F. HOFFMAN, VLADIMIR PISHKIN
Journal: American Journal of Psychiatry (1961)

Imipramine and nialamide were found to be comparable as measured by psychiatrist's clinical ratings of over-all improvement in patients with depressive symptoms. On measures of specffic behavioral factors on the MACC scale the two drug groups were differentiated by improved motility in patients on imipramine and by positive changes in affect in patients receiving nialamide during the first 6 weeks of drug administration.
Regular review: Ulcerative colitis
Authors: S. Ghosh
Journal: BMJ (2000)

Ulcerative colitis is a relapsing and remitting disease characterised by acute non-infectious inflammation of the colorectal mucosa. In the United Kingdom the annual incidence is around 7 cases per 100 000 population.1 The rectal mucosa is invariably affected. Confluent inflammation and shallow ulceration extend proximally from the anal margin. A patient may have proctitis, left sided colitis (the proximal limit being below the splenic flexure), extensive colitis (involving the transverse colon), or pan colitis. At any point in time, 50% of patients are asymptomatic, 30% have mild symptoms, and 20% have moderate to severe symptoms.2 Many patients have long periods of complete remission, but the cumulative probability of remaining free from relapse at two years is only 20%, decreasing to less than 5% at 10 years.3 Later relapses generally affect the same region of the colon as previous episodes.


Several of the current clinical and therapeutic issues in ulcerative colitis include: (a) medical treatment options for relapse and for maintenance of remission; (b) management of the minority of patients who develop a severe life threatening relapse or chronic unremitting disease; (c) surgical treatment of ulcerative colitis; and (d) long term complications in patients with extensive disease—namely, colonic and biliary cancers and sclerosing cholangitis. 


Summary points


Ulcerative colitis may present at any age, but the anatomical distribution of involvement at presentation is different between children and adults


All patients with bloody diarrhoea need to have infection excluded


Outpatient rigid sigmoidoscopy is the best method of diagnosing the nature of inflammation


The extent of inflammation may be established by total colonoscopy (or a double contrast barium enema)


The mainstays of treatment are rectal and systemic 5-aminosalicylic acid derivatives and corticosteroids, with azathioprine in steroid dependent or resistant cases


Restorative proctocolectomy with ileal pouch-anal anastomosis should be considered in every patient in whom colectomy is contemplated
A SANITARY POCKET CUSPIDOR.
Authors: J. W. TRASK
Journal: JAMA (1904)

The cup I am about to describe was gotten up especially for use at the United States Public Health and Marine-Hospital Service Sanatorium for Consumptives at Fort Stanton, New Mexico. Many styles of cups had been in use at different times, but none was found very satisfactory. The hand cups were serviceable at the bedside, but the patients found them too clumsy for carrying about. They seemed to dislike the idea of always carrying a cup in the hand. The pocket flasks in use held so little that but a limited number of patients were able to use them and in addition they were continually getting out of order. Nor was there to be found on the market a cup or flask that seemed to meet the requirements any better than those already in use. What was needed was a cup that would go into the pocket and