tbuckley/cabot-search huggingface dataset:
Pulmonary Embolism: Suspicion and Tests
Authors: Leonard Sadoff
Journal: Annals of Internal Medicine (1991)

Letters1 May 1991Pulmonary Embolism: Suspicion and TestsLeonard Sadoff, MDLeonard Sadoff, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-9-808_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: In their recent review on diagnosing pulmonary embolism, Kelley and colleagues (1) fail to address a crucial point: In which patients do we suspect pulmonary embolism? The protean manifestations of this "Great Imitator" are often overlooked by the busy clinician; and even if the diagnostic accuracy of a test approaches 100%, it is not useful if it is not ordered in the appropriate clinical settings.Syncope, transient confusion, seizures, transient anxiety, and unexplained tachycardia are but a few of the signs and symptoms of pulmonary embolism that often are not recognized. How many clinicians train themselves to...Reference1. Kelley M, Carson J, Palevsky H, and Schwartz J. Diagnosing pulmonary embolism: new facts and strategies. Ann Intern Med. 1991;114:300-6. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Leonard Sadoff, MDAffiliations: Kaiser-Permanente Hospital Los Angeles, CA 90027 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1991Volume 114, Issue 9Page: 808-808KeywordsAnxietyEpileptic seizuresPulmonary embolismSigns and symptomsSyncopeTachycardia ePublished: 1 December 2008 Issue Published: 1 May 1991 PDF downloadLoading ...
Deterioration of Left Ventricular Chamber Performance After Bed Rest
Authors: Merja A. Perhonen, Julie H. Zuckerman, Benjamin D. Levine
Journal: Circulation (2001)

Orthostatic intolerance after bed rest is characterized by hypovolemia and an excessive reduction in stroke volume (SV) in the upright position. We studied whether the reduction in SV is due to a specific adaptation of the heart to head-down tilt bed rest (HDTBR) or acute hypovolemia alone.We constructed left ventricular (LV) pressure-volume curves from pulmonary capillary wedge pressure and LV end-diastolic volume and Starling curves from pulmonary capillary wedge pressure and SV during lower body negative pressure and saline loading in 7 men (25+/-2 years) before and after 2 weeks of -6 degrees HDTBR and after the acute administration of intravenous furosemide. Both HDTBR and hypovolemia led to a similar reduction in plasma volume. However, baseline LV end-diastolic volume decreased by 20+/-4% after HDTBR and by 7+/-2% after hypovolemia (interaction P<0.001). Moreover, SV was reduced more and the Starling curve was steeper during orthostatic stress after HDTBR than after hypovolemia. The pressure-volume curve showed a leftward shift and the equilibrium volume of the left ventricle was decreased after HDTBR; however, after hypovolemia alone, the curve was identical, with no change in equilibrium volume. Lower body negative pressure tolerance was reduced after both conditions; it decreased by 27+/-7% (P<0.05) after HDTBR and by 18+/-8% (P<0.05) after hypovolemia.Chronic HDTBR leads to ventricular remodeling, which is not seen with equivalent degrees of acute hypovolemia. This remodeling leads to a greater decrease in SV during orthostatic stress after bed rest than hypovolemia alone, potentially contributing to orthostatic intolerance.
Unraveling the genetic underpinnings of myeloproliferative neoplasms and understanding their effect on disease course and response to therapy: Proceedings from the 6th international post‐ASH symposium
Authors: Omar Abdel‐Wahab, Animesh Pardanani, Olivier A. Bernard, Guido Finazzi, John D. Crispino, Heinz Gisslinger, Robert Kralovics, Olatoyosi Odenike, Kapil Bhalla, Vikas Gupta, Giovanni Barosi, Jason Gotlib, Paola Guglielmelli, Jean‐Jacques Kiladjian, Pierre Noel, Mario Cazzola, Alessandro M. Vannucchi, Ronald Hoffman, Tiziano Barbui, Juergen Thiele, Richard A. Van Etten, Tariq Mughal, Ayalew Tefferi
Journal: American Journal of Hematology (2012)

Immediately after the annual scientific meeting of the American Society of Hematology (ASH), a select group of clinical and laboratory investigators in myeloproliferative neoplasms (MPN) is summoned to a post-ASH conference on chronic myeloid leukemia and the BCR-ABL1-negative MPN. The 6th such meeting occurred on December 13–14,2011, in La Jolla, California, USA, under the direction of its founder,Dr. Tariq Mughal. The current document is the first of two reports on this post-ASH event and summarizes the most recent preclinical and clinical advances in polycythemia vera, essential thrombocythemia,and primary myelofibrosis.
New health secretary warns further NHS efficiency savings may be needed
Authors: Z. Kmietowicz
Journal: BMJ (2010)

The new health secretary Andrew Lansley has said that the NHS may need to make more efficiency savings than the £20bn (€23bn; $29bn) it is planning to save by 2014.

Speaking on his first full day in the job on 13 May Mr Lansley told Radio 4’s Today programme that the NHS budget would rise above inflation in the years to come as pledged in the Conservative manifesto. This would help the NHS meet rising demands from an ageing population, he said.

But he also warned that productivity may have to improve beyond the £20bn announced by Labour appointed NHS chief executive David Nicholson in 2008 ( BMJ 2009;339:b5305;doi:10.1136/bmj.b5305).

Commenting on the figure on radio 4 Mr Lansley said, “Of course …
Radionuclide Bone Marrow Scanning and Computerized Tomography in the Diagnosis of Extramedullary Hematopoiesis Presenting as an Intrathoracic Paravertebral Mass
Authors: WILLIAM F. WOSICK, SHANTIKUMAR BEDMUTHA, BRUCE SMALL
Journal: Clinical Nuclear Medicine (1984)

A 37-year-old man with a history of chronic hemolytic anemia presented with severe anemia. Chest x-ray and computerized tomography of the chest demonstrated an intrathoracic paravertebral mass that was thought to represent a site of extramedullary hematopoiesis. Radionuclide bone marrow scanning using Tc-99m sulfur colloid confirmed the diagnosis. Hematologic studies correlated with the diagnosis of HEMPAS. In the appropriate clinical setting, noninvasive Tc-99m sulfur colloid bone marrow scanning and computerized tomography can adequately establish the diagnosis of extramedullary hematopoiesis in a patient who presents with an intrathoracic paravertebral mass, thus eliminating unnecesary surgical intervention.
Aplastic Anemia and Agranulocytosis in Patients Using Methazolamide for Glaucoma
Authors: Theodore P. Werblin
Journal: JAMA (1979)

Carbonic anhydrase inhibitors used in the treatment of glaucoma, seizure disorders, and hypertension are rarely associated with blood dyscrasias. Several case reports of aplastic anemia with use of acetazolamide, and two cases with use of methazolamide, have appeared in the literature. This article describes two cases of aplastic anemia, at least one of which was almost certainly induced by the use of methazolamide, and one case of agranulocytosis related to the use of methazolamide. (<i>JAMA</i>241:2817-2818, 1979)
Characterization and mapping of the multi-component release kinetics of a Traditional Chinese Medicine dosage form using a modified LC/MS/MS method and chemomic release kinetic theory
Authors: Hai-yan Li, Xiang-yong Cui, Feng Gao, Peter York, Qun Shao, Xian-zhen Yin, Tao Guo, Zhen Guo, Jing-kai Gu, Ji-wen Zhang
Journal: Acta Pharmaceutica Sinica B (2011)

It is essential to develop effective methods for the quality control of the traditional medicine with multiple components. However, few researches on the quality control have been conducted to interpret the holistic characteristics of the traditional medicine in terms of dissolution/release. In this study, the multi-component release kinetics of Traditional Chinese Medicine (TCM) dosage forms was characterized and mapped by multivariate analysis techniques in the field of “-omics”. The Liuweidihuang pill was used as a model formulation. The multi-component release kinetics of the concentrated and water-honeyed Liuweidihuang pills at rotation speeds of 50 and 100 rpm were analyzed by chemomic release kinetic theory and modified LC/MS/MS method. Mass features of 103 (concentrated pills) and 101 (water-honeyed pills) were selected with a linear correlation coefficient ≥0.99 between mass responses and concentrations. To compose the chemomic standard spectrum, the relative abundance of both mass features was no less than 1% as compared with an internal standard. The correlation coefficients between six samples of various solutions were in line with analytical requirements of precision (r≥0.985). The score plots of principal component analysis showed that the concentrated Liuweidihuang pills presented better chemomic release reproducibility than the water-honeyed pills. Conversely, the impact of rotation speed on the chemomic release was less obvious. The heat maps of hierarchical clustering analysis did not show significant changes in individual clusters of mass features along different time intervals, reflecting the release integrity of the mass features. Therefore, both multivariate analysis methods, the principal component analysis and the hierarchical clustering analysis, seemed to be effective techniques to demonstrate the multiple component release performance of TCM. The research provided the basis of a new strategy for the quality control procedures of the dissolution/release for the traditional medicine and multi-component natural products to address increasing regulatory requirements and scrutiny across the world.
A Case of Tetany Treated by Thyroid Extract
Authors: B. Bramwell
Journal: BMJ (1895)

TETANY TREATED BY THYROID EXTRACT.[JrNE 1, l.would propose, by suitable adjectives, to discriminate its different forms.For clinical purposes these latter present us with most important peculiarities of character.We may perhaps conveniently recognise three principal divisions, under each of which several groups may in the future be arranged: DivisioN I.-Rierpetiform morphcea; the patches being arranged on the pattern of herpes in streaks or bands, and, however extensively bilateral, seldom or never with exact symmetry.DIvIsION iI.-Acroteric morphcea, in which, although the whole skin may suffer more or less, the beginning and the greatest severity of the disease are almost invariably at the extremities.No location in streaks, symmetry always marked, and Raynaud's phenomena not unusual.This form is met with almost solely-in adult women, and shows no tendency to spontaneous cure.DIvIsioN Iiii.-Hide-bound conditions of skin, in which the subcutaneous tissue rather than the skin itself -is implicated.In this division are to be placed for the present certain cases which differ more or less definitely from both the preceding, and concerning the exact relations of which it is very diffi- cult to speak.There are no ivory patches, nor are the ex- tremities preferentially affected.These woodcuts show the state of the foot in the Liverpool case of morphcea affecting the saphena nerves.They are copied from drawings lent.
Lamivudine/interferon combination therapy for 12 months prevents the appearance of YMDD mutants in anti-hbe positive chronic hepatitis B patients: a controlled pilot study
Authors: T. Santantonio, G. Niro, E. Sinisi, M. Insalata, D. Facciorusso, E. Gravinese, A. Andriulli, G. Pastore
Journal: Journal of Hepatology (2001)
Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions
Authors: Olga Schulz, Elin Jaensson, Emma K. Persson, Xiaosun Liu, Tim Worbs, William W. Agace, Oliver Pabst
Journal: The Journal of Experimental Medicine (2009)

Chemokine receptor CX3CR1+ dendritic cells (DCs) have been suggested to sample intestinal antigens by extending transepithelial dendrites into the gut lumen. Other studies identified CD103+ DCs in the mucosa, which, through their ability to synthesize retinoic acid (RA), appear to be capable of generating typical signatures of intestinal adaptive immune responses. We report that CD103 and CX3CR1 phenotypically and functionally characterize distinct subsets of lamina propria cells. In contrast to CD103+ DC, CX3CR1+ cells represent a nonmigratory gut-resident population with slow turnover rates and poor responses to FLT-3L and granulocyte/macrophage colony-stimulating factor. Direct visualization of cells in lymph vessels and flow cytometry of mouse intestinal lymph revealed that CD103+ DCs, but not CX3CR1-expressing cells, migrate into the gut draining mesenteric lymph nodes (LNs) under steady-state and inflammatory conditions. Moreover, CX3CR1+ cells displayed poor T cell stimulatory capacity in vitro and in vivo after direct injection of cells into intestinal lymphatics and appeared to be less efficient at generating RA compared with CD103+ DC. These findings indicate that selectively CD103+ DCs serve classical DC functions and initiate adaptive immune responses in local LNs, whereas CX3CR1+ populations might modulate immune responses directly in the mucosa and serve as first line barrier against invading enteropathogens.
Applying Market Justice to Health Care—Reply
Authors: Peter P. Budetti
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Infectious Mononucleosis vs. Glandular Fever: A Case of Mistaken Identity.
Authors: R. J. Hoagland
Journal: Annals of Internal Medicine (1963)

s1 April 1963Infectious Mononucleosis vs. Glandular Fever: A Case of Mistaken Identity.R. J. Hoagland, M.D., F.A.C.P.R. J. Hoagland, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-739_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has become a ritual for medical writers to begin a textbook, and often, articles in journals on infectious mononucleosis by stating the disease was first described by Pfeiffer under the name of "Druesenfieber" (glandular fever) in 1889. Wising stated that Filatow, in 1885, described what probably was mononucleosis, but "the honor of distinguishing infectious mononucleosis as a characteristic entity" should be ascribed to Pfeiffer.Now, this is very odd because mononucleosis, of course, means predominance of mononuclear leukocytes, but neither Filatow nor Pfeiffer knew of differential blood counts. Examination of stained blood smears had not yet been introduced into... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: R. J. Hoagland, M.D., F.A.C.P.Affiliations: Honolulu, Hawaii (CS) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 739-739KeywordsBloodBlood countsFeversInfectious diseases ePublished: 1 December 2008 Issue Published: 1 April 1963 PDF downloadLoading ...
Oesophageal epithelial innervation in health and reflux oesophagitis
Authors: M Newton, M A Kamm, P O Soediono, P Milner, W R Burnham, G Burnstock
Journal: Gut (1999)

The response of the oesophagus to refluxed gastric contents is likely to depend on intact neural mechanisms in the oesophageal mucosa. The epithelial innervation has not been systematically evaluated in health or reflux disease.To study oesophageal epithelial innervation in controls, and also inflamed and non-inflamed mucosa in patients with reflux oesophagitis and healed oesophagitis.Ten controls, nine patients with reflux oesophagitis, and five patients with healed oesophagitis.Oesophageal epithelial biopsy specimens were obtained at endoscopy. The distribution of the neuronal marker protein gene product 9.5 (PGP), and the neuropeptides calcitonin gene related peptide (CGRP), neuropeptide Y (NPY), substance P (SP), and vasoactive intestinal peptide (VIP) were investigated by immunohistochemistry. Density of innervation was assessed by the proportion of papillae in each oesophageal epithelial biopsy specimen containing immunoreactive fibres (found in the subepithelium and epithelial papillae, but not penetrating the epithelium).The proportion of papillae positive for PGP immunoreactive nerve fibres was significantly increased in inflamed tissue when compared with controls, and non-inflamed and healed tissue. There was also a significant increase in VIP immunoreactive fibres within epithelial papillae. Other neuropeptides showed no proportional changes in inflammation.Epithelial biopsy specimens can be used to assess innervation in the oesophagus. The innervation of the oesophageal mucosa is not altered in non-inflamed tissue of patients with oesophagitis but alters in response to inflammation, where there is a selective increase (about three- to fourfold) in VIP containing nerves.
TRAUMATIC IMPLANTATION OF EPITHELIAL CYST IN A PHALANX
Authors: Samuel C. Yachnin
Journal: JAMA (1941)

The occurrence of an epithelial cyst enclosed within the bony structure of a phalanx of a finger is a rare condition, for such a case has not been reported in the medical literature of this country. Neither can it be found mentioned in the recent textbooks of general and orthopedic surgery, of tumors and also of bone diseases. So to present a case in which it was found should be of interest. An explanation of its origin embraces two possibilities: first, that of congenital malformation with inclusion of aberrant epithelial cells, comparable to the formation of a simple dermoid cyst; second, that of traumatic implantation. <h3>CASES REPORTED</h3> Five cases have been found recorded in the European medical literature; this presentation makes a sixth case, the first in America. The first recorded was one by Sonntag<sup>1</sup>in 1923: A young female injured the left hand in a machine, crushing the
Improvement in Exercise Performance by Inhalation of Methoxamine in Patients with Impaired Left Ventricular Function
Authors: Laure Cabanes, Frederic Costes, Simon Weber, Jacques Regnard, Christophe Benvenuti, Alain Castaigne, François Guerin, Alain Lockhart
Journal: New England Journal of Medicine (1992)

Bronchial hyperresponsiveness to cholinergic stimuli such as the inhalation of methacholine is common in patients with impaired left ventricular function. Such hyperresponsiveness is best explained by cholinergic vasodilation of blood vessels in the small airways, with extravasation of plasma due to high left ventricular filling pressure. Because this vasodilation may be prevented by the inhalation of the vasoconstrictor agent methoxamine, we studied the effect of methoxamine on exercise performance in patients with chronic left ventricular dysfunction.
Does the relationship between IgE and the CD14 gene depend on ethnicity?
Authors: G. Zhang, J. Goldblatt, P. N. LeSouëf
Journal: Allergy (2008)

This review considers the data from studies analysing associations between the CD14C−159T single nucleotide polymorphism (SNP) and asthmatic phenotypes and discusses the variability of the conclusions. By searching PubMed and EMBASE for articles on CD14C−159T ‐related population or family‐based association studies, 47 were identified up till September 2007. Collectively, the studies reviewed herein consistently showed population differences in frequencies of the alleles of the SNP, with African descent having the highest C allele frequencies, followed by Caucasians and Asians. The T allele of the SNP was associated with increased sCD14 in some studies but not in others. Inconsistently, the C allele, or even occasionally the T allele, was associated with atopic phenotypes in a population subgroup. There are several explanations for these inconsistencies, including lack of power, linkage disequilibrium, gene–gene interactions, population admixture and gene–environment interactions. If the SNP was associated with functional changes to the coded protein and thus modulating susceptibility to allergic disease, its effect may be modest and dependent on other co‐existent, ethnicity‐specific, genetic or environmental risk factors.
Hamish Torrie Hutchinson
Authors: J. Hutchinson
Journal: BMJ (2008)

Hamish Torrie Hutchinson graduated from King’s College Hospital, London, in 1972, underwent further training at Plymouth and King’s before joining the Southampton and Basingstoke senior registrar rotation. In 1979 he was appointed consultant anaesthetist at Tunbridge Wells, where he started the Chronic Pain Unit, based at Pembury Hospital. With support from his …
Abstract 4316: A novel wide field-of-view imaging device for real-time, intra-operative tumor bed assessment
Authors: Jeffrey K. Mito, Jorge M. Ferrer, Brian E. Brigman, Chang-Lung Lee, Rebecca D. Dodd, William C. Eward, Lisa F. Marshall, David Dankort, Martin McMahon, Yongbaek Kim, W. David Lee, Linda G. Griffith, Moungi G. Bawendi, David G. Kirsch
Journal: Cancer Research (2010)

Abstract Limb-sparing surgery for extremity soft tissue sarcoma removes all cancer cells at the primary tumor site in the majority of patients. However, without radiation therapy, microscopic residual sarcoma cells left behind in the tumor bed will cause a tumor recurrence in approximately one-third of patients. Therefore, adjuvant radiation therapy is delivered to most patients, even when the tumor bed lacks residual cancer. Here, we present an imaging system for residual cancer assessment, consisting of a novel wide field-of-view imaging device and a protease-activated fluorescent probe. We demonstrate that this system directly images microscopic residual sarcoma cells in the tumor bed of mice when primary soft tissue sarcomas are resected. Moreover, this system can detect single tumor cells that have activated the fluorescent probe in vivo. This technology has the potential to be used as an intra-operative tool to identify microscopic residual disease for soft tissue sarcoma and other cancers with the goal of reducing rates of local recurrence, re-operation for positive margins, and adjuvant radiation therapy to tumor beds that lack residual cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4316.