tbuckley/cabot-search huggingface dataset:
Pacing and reperfusion induced arrhythmias: protection by slow heart rate in the rat heart
Authors: A. TOSAKI, S. BALINT, L. SZEKERES
Journal: Cardiovascular Research (1988)

Journal Article Pacing and reperfusion induced arrhythmias: protection by slow heart rate in the rat heart Get access ARPAD TOSAKI, ARPAD TOSAKI From the Department of Pharmacology, Szeged Medical University, Szeged, Hungary Search for other works by this author on: Oxford Academic PubMed Google Scholar SUSAN BALINT, SUSAN BALINT From the Department of Pharmacology, Szeged Medical University, Szeged, Hungary Search for other works by this author on: Oxford Academic PubMed Google Scholar LASZLO SZEKERES LASZLO SZEKERES From the Department of Pharmacology, Szeged Medical University, Szeged, Hungary Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 22, Issue 11, November 1988, Pages 818–825, https://doi.org/10.1093/cvr/22.11.818 Published: 01 November 1988 Article history Received: 08 March 1988 Accepted: 08 June 1988 Published: 01 November 1988
Fundamentals of Mobile Coronary Care: A Training Manual for Emergency Medical Technicians
Authors: G. Jawad
Journal: JAMA (1979)

Mobile coronary care units render life-saving support for cardiac patients. They require emergency medical technicians well trained in cardiac resuscitation and defibrillation. This book describes in a simple and concise manner all the basic material they need for the practical treatment of the distressed patient. It is richly illustrated. This book would be of interest to nurses and physicians also.
COAGULATION TIME OF THE BLOOD IN LOBAR PNEUMONIA
Authors: A. R. Dochez
Journal: The Journal of Experimental Medicine (1912)

The coagulation time of the blood is generally prolonged during the acute stage of lobar pneumonia, returning to normal during the period of convalescence. There seems to be a simultaneous increase in the quantity of circulating fibrinogen. The lengthening of the coagulation time is probably due to an increased formation of antithrombin. The source of the increased antithrombin and fibrinogen is probably the liver, and the stimulus to increased production of these two substances is due to the nature of the infecting organism.
DANGERS OF BICYCLING; WITH REPORT OF A CASE OF ACUTE DILATATION OF THE HEART.
Authors: WILLIAM C. KRAUSS
Journal: JAMA (1896)

Ever since the great popularity which has attended bicycling in this country, numerous articles have appeared in the medical and lay press pointing out real and imaginary dangers liable to beset those attracted to this sport. These dangers have attended both sexes, more particularly the female bicyclists, and consisted in disturbances affecting the pelvic viscera. No doubt over-indulgence in this pastime can and will produce congestions and irritations of these organs, perhaps displacements and even inflammations, but such cases are comparatively rare. From the moral point of view another danger has been discovered by the Woman's Rescue League of Washington: That the bicycle is nothing more or less than the devil's advance agent, and through the opportunities which it offers is causing an alarming increase of immorality among women. The writer believes this to be true only in so far as it affects those women upon whom the devil already
Substance Use and Abuse
Authors: Elizabeth J. Thomson
Journal: JAMA (1991)

<h3>To the Editor.</h3> — I have often pondered what characteristics authors and editors use to distinguish between substance<i>use</i>(utilization, employment, habituation) and substance<i>abuse</i>(misuse, incorrect or improper use, corrupt practice). I wondered if an objective guideline had been developed beyond which substance<i>use</i>becomes substance abuse. After reading recent<i>JAMA</i>articles,<sup>1-3</sup>one explanation seems obvious. It may not be the specific agent used or the amount of the agent employed as much as it is the race, ethnicity, socioeconomic status, gender, pregnancy status, or the profession of the abuser. I think both authors of articles and editors of professional journals ought to consider this issue and the implications of the messages they are sending.
Issues in the use of inhaled glucocorticoids. The Asthma Clinical Research Network.
Authors: A K Kamada, S J Szefler, R J Martin, H A Boushey, V M Chinchilli, J M Drazen, J E Fish, E Israel, S C Lazarus, R F Lemanske
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

"Issues in the use of inhaled glucocorticoids. The Asthma Clinical Research Network.." American journal of respiratory and critical care medicine, 153(6), pp. 1739–1748
Pigment gallstone disease: Summary of the national institutes of health-international workshop
Authors: Bruce W. Trotman, Roger D. Soloway
Journal: Hepatology (1982)

This report summarizes the proceedings of the first National Institutes of Health—International Workshop on Pigment Gallstone Disease. The meeting held at the University of Pennsylvania in May, 1981 consisted of eight sessions in which the following aspects of pigment gallstone disease were discussed: (a) classification; (b) epidemiology; (c) radiographic assessment; (d) gallstone composition; (e) composition of bile; (f) pathogenesis; (g) animal models, genetics, and computer analysis, and (h) medical treatment. The interaction of participants interested in various aspects of pigment stone disease was stimulating. This workshop should be a major stimulus for future studies in this relatively neglected, but important area of biliary tract lithiasis.
Ascorbic Acid-Induced Hemolysis in G-6-PD Deficiency
Authors: G. DOUGLAS CAMPBELL
Journal: Annals of Internal Medicine (1975)

LettersJune 1, 1975Ascorbic Acid-Induced Hemolysis in G-6-PD DeficiencyG. DOUGLAS CAMPBELL JR., B.A., MARTIN H. STEINBERG, M.D., F.A.C.P., JOHN D. BOWER, M.D., F.A.C.P.G. DOUGLAS CAMPBELL JR., B.A., MARTIN H. STEINBERG, M.D., F.A.C.P., JOHN D. BOWER, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-6-810_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThough the origins of erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) deficiency are rooted in human antiquity, the presence of drug-induced hemolysis in individuals subsequently felt to have G-6-PD deficiency was first reported in 1926 and the biochemical lesion responsible for this phenomenon elucidated in 1956 (1). In the United States, hemolysis induced by infection or drugs is the most common clinical manifestation of G-6-PD deficiency (2).Ascorbic acid (vitamin C), an essential vitamin, is commonly used in pharmacologic doses for the prevention of the common cold and to promote the healing of wounds. We report here an individual with G-6-PD deficiency who...References1. BEUTLER E: The hemolytic effect of primaquine and related compounds: a review. Blood 14:103-138, 1959 CrossrefGoogle Scholar2. BEUTLER E: Abnormalities of the hexose monophosphate shunt. Semin Hematol 8:311-347, 1971 Google Scholar3. STEINBERGDREILING MB: Glucose-6-phosphate dehydrogenase deficiency in sickle-cell anemia: a study in adults. Ann Intern Med 80:217-220, 1974 LinkGoogle Scholar4. SCHWARTZTOGOHORNICK AYR: Evaluation of the efficacy of ascorbic acid in prophylaxis of induced rhinovirus 44 infection in man. J Infect Dis 128:500-505, 1973 CrossrefGoogle Scholar5. BREWERTARLOVALVING GAA: Standardization of procedures for the study of glucose-6-phosphate dehydrogenase. WHO Tech Rep Ser No. 366, 1967, p. 27 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Divisions of Hematology and Nephrology Department of Medicine University of Mississippi School of Medicine Jackson, Mississippi 39216 Special Hematology Laboratory Veterans Administration Hospital Jackson, Mississippi 39216 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAscorbic Acid Effects on ErythrocytesCHARLES E. MENGEL, M.D., HARRY L. GREENE JR., M.D.Ascorbic Acid-Induced Uricosuria A Consequence of Megavitamin TherapyHOWARD B. STEIN, M.D., F.R.C.P.(C), ARJUMAND HASAN, IRVING H. FOX, M.D., C.M., F.R.C.P.(C) June 1, 1975Volume 82, Issue 6Page: 810-810KeywordsAcidsCommon coldDehydrogenasesGlucose-6-phosphate dehydrogenase deficiencyVitamin C Issue Published: June 1, 1975 PDF DownloadLoading ...
How heavy the patient?
Authors: K McKay, S Fozdar-Faroudi, C E Bowman
Journal: BMJ (1991)

antacid) tends to stick in the mind.Glaxo is now showing signs of a mild addiction to names beginning with Z -Zinacef, Zinnat, Zofran.Tixylix (Intercare) is an odd name by any standards and is difficult to spell.It does, however, have a certain charm and sounds attractive.Prefil (Norgine), the appetite suppressant, is a minor classic of its kind: two syllables; simple; and the name captures the action of the product beautifully.The prize for making the best use of seven letters must go to ICI for its succession of X blockers: Alderin, Eraldin, and Inderal.There is still a good bit of milage left in this combination-Derlain, Darnile, Rednail, and Ireland would do for another four ,6 blockers.Most of the following are not available in English speaking countries and we believe that they are unlikely to make it internationally.Would you buy- or prescribe-Arsobal, Bumal, Kriplex, Nokhel, Rogorin, Snootie, or Widocillin? 1
Abstract 1190: Multifactorial biological processes govern engraftment of patient-derived tumor tissue in immunodeficient mice
Authors: David M. Vasquez-Dunddel, Gilson Baia, Amanda Katz, Daniel Ciznadija, David Sidransky, Keren Paz
Journal: Cancer Research (2014)

Abstract TumorGrafts (also known as patient-derived xenografts) are a valuable tool for the personalization of oncology treatment, as well as development of new cancer therapeutics. Tumor explants are engrafted into immunodeficient mice and allowed to develop prior to screening against a panel of drugs or drug combinations to assess which best inhibit tumor growth. These models capture the chaotic heterogeneity, histopathology, and biology of the original tumor, as well its 3-dimensional interaction with the surrounding stroma and other cells migrating into the tumor environment. TumorGrafts will serve basic and clinical research groups as an increasingly valuable preclinical model of cancer. One important variable governing the generation of these models is the take rate, or the percentage of patient tumors that successfully engraft and grow in the mice. This is a potentially critical limitation to applying these preclinical models for improving patient treatment and advancing novel drug regimens to the clinic. Hence, there is a need to understand and exploit the mechanisms that influence take rate in order to ensure that the majority of tumor explants readily engraft and expand. We describe here our experience in optimizing the engraftment of patient tumor tissue in immunodeficient mice. We found a number of factors contribute to take rate including tumor type, tissue quantity and quality, engraftment site, oxygenation state, neovascularization and the presence of extracellular stromal components and cells. We have also uncovered a correlation between the growth rate of tumors in the mice and the clinical aggressiveness of the original malignancy, information that may be useful in guiding clinical management. Moreover, we describe how we are now able to consistently use biopsy material rather than surgical explants to establish TumorGrafts, a crucial step forward that allows this technology to benefit patients diagnosed with early-stage cancers or where surgery is not indicated. Although engraftment of patient tumor tissue in immunodeficient mice is a complex process, with multiple factors impacting success, we have effectively optimized this process, improving our take rate and at the same time, reducing the time to obtaining drug screening results, all without compromising tumor integrity. Citation Format: David M. Vasquez-Dunddel, Gilson Baia, Amanda Katz, Daniel Ciznadija, David Sidransky, Keren Paz. Multifactorial biological processes govern engraftment of patient-derived tumor tissue in immunodeficient mice. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1190. doi:10.1158/1538-7445.AM2014-1190
HIV Screening in Health Care Settings
Authors: Roland C. Merchant, Michael J. Waxman
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2022 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gene expression profiles of human proximal tubular epithelial cells in proteinuric nephropathies
Authors: M. Rudnicki, S. Eder, P. Perco, J. Enrich, K. Scheiber, C. Koppelstätter, G. Schratzberger, B. Mayer, R. Oberbauer, T.W. Meyer, G. Mayer
Journal: Kidney International (2006)
More Than We Ever Wanted to Know about Sex — Should We Be Afraid to Ask?
Authors: Joe Leigh Simpson
Journal: New England Journal of Medicine (1979)

A desire to control the sex of offspring has intrigued aspiring parents since antiquity. Aristotle is said to have rejected the contention of Empedocles that timing of intercourse affected sex ratio.1 In more recent times, many methods of influencing sex ratios have been proposed. Partial differential separation of X and Y-bearing mammalian sperm has been attempted in vitro by density-gradient sedimentation, electrophoresis and immunologic (anti H-Y) absorption.2 Separation is often inconsistent, sometimes species specific and usually no more than 60 to 70 per cent successful.2 In addition, the safety of subjecting human sperm to in vitro manipulations is difficult to . . .
IL23R and IL12B genes: susceptibility analysis in rheumatoid arthritis
Authors: J Varade, J Ramon Lamas, L Rodriguez, M Fernandez-Arquero, E Loza-Santamaria, J A Jover, E G de la Concha, B Fernandez-Gutierrez, E Urcelay, A Martinez
Journal: Annals of the Rheumatic Diseases (2009)

The identification of additional genetic risk factors is an ongoing process that will aid in the understanding of rheumatoid arthritis (RA) aetiology. A genome-wide association scan in Crohn’s disease highlighted the IL23R gene as a susceptibility factor.1 The IL-23 receptor is a heterodimer formed by the products of two different genes: IL23R and IL12RB . Our aim was to analyse whether polymorphisms within the genes coding for the specific chain of the IL-23 receptor ( IL23R ) and for its p40 ligand ( IL12B ) and interacting in psoriasis2 are also associated with an altered risk of RA.

In agreement with previously published data,3–6 no statistically significant association was found with the IL12B polymorphisms (table 1).

View this table:

Table 1 Association of IL23R (rs7517847 and rs11209026) and IL12B (rs6887695 and rs322227) SNP with RA

The minor alleles of the IL23R polymorphisms were associated with increased predisposition to …
Serum kynurenine in rheumatoid arthritis
Authors: Harry Spiera, Ramon Vallarino
Journal: Journal of Clinical Investigation (1969)

The concentration of kynurenine has been measured in the serum of patients with rheumatoid arthritis and in a control group. The mean serum concentration was 2.27 +/- 0.688 mug/ml for patients with rheumatoid arthritis and 2.95 +/- 0.825 mug/ml for the control group.KYNURENINE: creatinine clearance ratios were higher in the rheumatoid arthritis than in the control group. These data suggest that the increased urinary excretion of kynurenine by patients with rheumatoid arthritis is due at least in part to renal factors.
Bilateral Hydrothorax From Unilateral Subclavian Vein Catheterization
Authors: Mahesh K. Agarwal
Journal: JAMA (1978)

To the Editor.—  Subclavian veins are being used with increasing frequency for fluid administration, hyperalimentation, and central venous pressure monitoring. Several complications of this procedure have been described by various authors 1-3 and include pneumothorax with or without subcutaneous emphysema and hemothorax, air embolism, catheter embolization, infection, subclavian artery puncture, myocardial perforation, thrombophlebitis and thrombosis, subcutaneous hematoma, brachial plexus palsy, innominate vein perforation, thoracic duct laceration, phrenic nerve paralysis, arteriovenous fistula, and interstitial pulmonary edema with chest wall abscess formation. The occurrence of hydrothorax has been reported to occur ipsilaterally unless the catheter perforates through mediastinum, causing bilateral pleural effusions and mediastinal emphysema. We report a case of bilateral pleural effusion occurring after right-sided subclavian vein catheterization without the displacement of the catheter to the opposite side.  Report of a Case.—  A 33-year-old woman with a history of heroin addiction and seizure disorder was hospitalized because of acute gastritis. Results
Abstract 3500: Histone deacetylator (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA) sensitizes squamous carcinoma cells of lung to pemetrexed
Authors: Soyeon Kim, Tae Min Kim, Se-Hoon Lee, Dong-Wan Kim, Dae Seog Heo
Journal: Cancer Research (2011)

Abstract Objectives: The multitargeted antifolate pemetrexed is approved as a first-line or second-line treatment of nonsquamous nonsmall cell lung cancer. The expression of the thymidylate synthase (TS) gene may mediate resistance to pemetrexed. In this study, we investigated whether the pemetrexed in combination with SAHA enhances the cytotoxicity of squamous carcinoma cells of lung. Methods: Squamous carcinoma cells of lung (NCI-H157, HCC-95 and HCC-1588) were exposed to 10-3M to 10-7M of pemetrexed with various HDAC inhibitors and their cytotoxicities were analyzed using the colorimetric assay. Cell cycle and apoptosis analyses were evaluated by flow cytometry. The mRNA and cellular protein levels were detected by RT-PCR and western blot assay. Results: After NCI-H157 was exposed to SAHA, TS mRNA and protein expression levels were strongly suppressed by time and dose-dependent manner, respectively. Additionally, although pemetrexed activated phosphorylation of AMPK-α, secondary target (AICAR) of pemetrexed, co-treatment of pemetrexed and SAHA decreased phosphorylation of AMPK-α and mTOR pathway. NCI-H157, HCC-95, and HCC-1588 treated with sequential SAHA (24h) followed by SAHA plus pemetrexed (72h) represented more synergistic cytotoxicities than those treated with simultaneous 96h exposure combination (p&amp;lt;0.05). This sequential treatment was significantly associated with TS inhibition as well as apoptosis of squamous carcinoma cells. While pemetrexed increased expressions of p21, PARP, and cleaved caspase 3 and reduced expression of bcl-2, the combination of pemetrexed and SAHA additionally increased the pro-apoptotic molecules. Sequential treatment of SAHA followed by pemetrexed resulted in 10-fold and 1.6-fold higher sub-G1 portions than control and pemetrexed alone groups, respectively in NCI-H157 cell. In particular, the sequential administration produced more apoptotic index as compared to pemetrexed alone in NCI-H157 cell (27% vs 8%). Conclusion: Our results demonstrate SAHA reduces TS expression and sequential treatment with pemetrexed has a synergistic cytotoxicity in squamous cell carcinoma of lung. Sequential treatment of SAHA and pemetrexed might be a new strategy to overcome pemetrexed resistance in patients with squamous cell carcinoma of lung. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3500. doi:10.1158/1538-7445.AM2011-3500
Mdr 2 Knockout mice link biliary phospholipid deficiency with small bile duct destruction
Authors: Cynthia R. Leveille-Webster, Irwin M. Arias
Journal: Hepatology (1994)

Two types of P-glyeoprotein have been found in mammals: the drug-transporting P-glycoproteins and a second type, unable to transport hydrophobic anti-cancer drugs. The latter is encoded by the human MDR3 (also called MDR2) and the mouse mdr2 genes, and its tissue distribution (bile canalicular membrane of hepatocytes, B cells, heart, and muscle) suggests a specialized metabolic function. We have generated mice homozygous for a disruption of the mdr2 gene. These mice develop a liver disease that appears to be caused by the complete inability of the liver to secrete phospholipid into the bile. Mice heterozygous for the disrupted allele had no detectable liver pathology, but half the level of phospholipid in bile. We conclude that the mdr2 P-glycoprotein has an essential role in the secretion of phosphatidylcholine into bile and hypothesize that it may be a phospholipid transport protein or phospholipid flippase.
Psittacosis Treated with Penicillin
Authors: J. R. Tasker
Journal: BMJ (1949)

erupted teeth contain two structures which differ in biochemical nature; one is a mucoprotein.Enamel at eruption is covered with a layer of protein, and is permeated with protein throughout life.Enamel protein is a mucoprotein, which comprises a class of proteins containing mucoitin sulphuric acid.Dentine contains chondroitin sulphuric acid.Gram-negative bacilli found in caries can release an enzyme -sulphatase.Sulphatase can release sulphuric acid from such combined forms as mucoitin sulphuiric acid and chondroitin sulphuric acid, thus attacking the calcium salts of both enamel and dentine and causing caries.