tbuckley/cabot-search huggingface dataset:
Haemoperitoneum after traumatic avulsion of uterine fibroid.
Authors: C. W. Venables, I. L. Craft
Journal: BMJ (1967)

On arrival she was intensely cyanosed, pulseless, and apnoeic.Cardiac massage and intermittent positive-presgure ventilation were started immediately and the cardiac arrest team was summoned.Ophthalmoscopic examination at this time showed widespread " rail- roading " in the retinal vessels.An E.C.G. showed ventricular fibrillation against a background of severe electrical interference.In view of the doubt on how long she had been in circulatory arrest it was decided to defibrillate the heart.This.was done externally with a single shock and was immediately followed by good heart action.A later examination of the fundi showed normal vessel architecture, though there was widespread oedema of the, fundi.Despite dehydration therapy with mannitol, hypothermia, artificial ventilation, etc., she did not regain consciousness.An E.E.G. taken the next day with a portable electroencephalograph showed wide- spread abnormal activity with high-voltage spikes alternating with slow waves every one to two seconds.Regular spontaneous respira- tion did not return until eight days after admission.Fourteen days after admission she developed pneumonia and died.At necropsy there was widespread diffuse infarction of the cerebral cortex, hypothalamus, right caudate nucleus, and pons.COMMENT
The Challenge of Thrombophilia in Maternal–Fetal Medicine
Authors: Ian A. Greer
Journal: New England Journal of Medicine (2000)

Twenty years ago we did not have a problem with thrombophilia as a cause of venous thromboembolism in pregnant and postpartum women, or rather, we did not know we had a problem. The only known major thrombophilic disorder was deficiency of antithrombin, and it was found only rarely in such women. Recently, there has been a dramatic increase in the number of identifiable causes of thrombophilia. They include, in addition to antithrombin deficiency, protein C and protein S deficiencies, factor V Leiden, the G20210A mutation of the prothrombin gene, and homozygosity for the thermolabile variant of methylenetetrahydrofolate reductase (C677T MTHFR), . . .
Medicolegal: Judge "not satisfied" that whooping cough vaccine causes permanent brain damage
Authors: C. Dyer
Journal: BMJ (1988)

A report is given of the British High Court ruling which, unless overturned on appeal, will stop all future payments under the government's no fault scheme for compensation for permanent brain damage caused by the pertussis vaccine. The Lord Justice indicated that although he had believed that the vaccine could cause permanent brain damage when he had embarked on the case, he was more impressed by the "quality of evidence and reasoning" of the ten experts called by the vaccine manufacturer than by the mechanism of injury proposed by the nine experts called by the plaintiff. He also concluded that examination of the data compiled by the National Childhood Encephalopathy Study failed to show that brain damage was caused by the vaccine rather than by an underlying condition.
THE PHYSIOLOGIC EFFECTS OF NONLIVING TESTIS GRAFTS
Authors: CARL R. MOORE
Journal: JAMA (1930)

Transplantation into man of whole, or parts of, testicles as a therapeutic measure has been practiced to some extent by surgeons and urologists in both this and foreign countries. The premises for such procedures have been the loss of both testicles through injury or removal, or, more often, an assumed hypogonadism in a patient whose own organs were diagnosed as below normal function in the production of their internal secretions. The latter diagnosis is of particular interest because of the fact that up to the present time there have been no recognized means of detecting a low male hormone state in man; ephemeral indexes have been assumed to be indicative of this condition just as equally elusive and questionable psychic reactions have been assumed to indicate increases in hormone titer after certain manipulations.  A review of the literature on testis transplantation into man during the last twenty years acquaints one
The Effect of g-Irradiation on the Adherent Capacity and Iron Metabolism of Alveolar Macrophages in Mice and Rats
Authors: Yoshihisa Kubota, Hiroshi Sato, Sentaro Takahashi
Journal: Environmental Health Perspectives (1992)

The effect of external gamma-irradiation on the survival of alveolar macrophages (AM) and on the extracellular release of 59Fe from AM-ingested [59Fe]iron hydroxide colloid was investigated in vitro using cells from C3H mice and Wistar rats. 59Fe release from mouse AM was enhanced by irradiation in a dose-dependent fashion, but irradiation up to 112 Gy did not affect the release from rat AM. Cell survival of AM, measured by direct counting of cell nuclei of adherent AM or vital staining with crystal violet, decreased dose dependently in mice and rats, but mouse AM were more radiosensitive than rat AM.
Disseminated intravascular coagulation due to cytomegalovirus infection in an immunocompetent adult treated with plasma exchange
Authors: Timothy B. Niewold, John B. Bundrick
Journal: American Journal of Hematology (2006)

We report the case of an immunocompetent woman who developed disseminated intravascular coagulation (DIC) due to acute cytomegalovirus (CMV) infection and was successfully treated with plasma exchange. Extensive investigations revealed no other cause for her DIC, and she did not have any recurrence after more than 1 year of follow up. Clinically evident DIC due to CMV infection is most common in immunosuppressed patients. The one previously reported immunocompetent patient with DIC due to acute CMV infection died from the illness despite traditional supportive measures. Plasma exchange is a novel therapy that should be considered in this situation.
Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression
Authors: Philip A. Beer, David J. H. F. Knapp, Paul H. Miller, Nagarajan Kannan, Ivan Sloma, Kathy Heel, Sonja Babovic, Elizabeth Bulaeva, Gabrielle Rabu, Jefferson Terry, Brian J. Druker, Marc M. Loriaux, Keith R. Loeb, Jerald P. Radich, Wendy N. Erber, Connie J. Eaves
Journal: Blood (2014)
A Case of Lymphosarcoma Associated with Myopathy
Authors: G. Arapakis, J. Jordanoglou
Journal: BMJ (1964)

Medical Memoranda JBRoIuHittaddu, an island some 5 miles (8 km.) away.During the journey in a native rowing-boat he became unconscious and arrived at the station sick quarters at 2 p.m.The patient remained unconscious during examination and responded slightly to painful stimuli.He was bleeding from a right fronto-parietal scalp wound 3 in.(7.5 cm.) in length.There was bruising and " bogginess " on the right temporal region and blood was present in the right middle-ear.A fracture of the vault and base of the skull was confirmed by x-ray examination.A dilated and fixed right pupil and a constricted left pupil together with a left hemiparesis suggested that in addition there was an extradural haemorrhage on the right side and it was thought that decompression was urgently required.
Psychological and Somatic Symptoms in Young Adults with Chronic Physical Diseases
Authors: Jorma Kokkonen, Eeva-Riitta Kokkonen
Journal: Psychotherapy and Psychosomatics (1995)

To find out whether a long-term physical illness since childhood increases the risk of experiencing psychological and somatic symptoms, we interviewed a group of 487 patients aged 20-25 years and compared these findings to 211 controls. Both somatic (chi 2 = 9.11, d.f. = 6, p < 0.001) and psychological (chi 2 = 11.0, d.f. = 6, p < 0.001) symptom indexes varied significantly between the patient groups. Female sex, family conflicts during childhood, poor scholastic performance and depressive mental disorders were especially observed to be significant risk factors related to an excessive occurrence of these symptoms. The results suggest that a disabling disease lasting from childhood unit adulthood is complicated by a significant incidence of both psychological and somatic symptoms.
A Ghost of the Past
Authors: Meredith Lash-Dardia
Journal: Annals of Internal Medicine (2012)

On Being a Doctor16 October 2012A Ghost of the PastMeredith Lash-Dardia, MDMeredith Lash-Dardia, MDFrom Weill Cornell Medical College, New York, NY 10075.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-8-201210160-00017 Audio Reading - “A Ghost of the Past” Audio. Listen to a reading of "A Ghost of the Past" by Meredith Lash-Dardia, MD. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail My kids just went trick-or-treating without me. Unceremoniously, they let me know that I slowed them down and was no longer welcome to join them as they ran house to house, filling pillowcases until they had to throw them over their shoulders for balance and trudge home like filthy Santa Clauses.Walking home, I came across little chickens waddling up the steps to ring doorbells, tiny Supermen and Cinderellas tottering up walkways while parents and grandparents doted nearby, cameras recording each piece of candy hitting the bag.Despite the excitement, or perhaps because of it, these kids have about 1 ... Author, Article, and Disclosure InformationAffiliations: From Weill Cornell Medical College, New York, NY 10075.Corresponding Author: Meredith Lash-Dardia, MD, Weill Cornell Medical College, 211 East 80th Street, New York, NY 10075; e-mail, [email protected]. PreviousarticleNextarticle Advertisement Audio Reading - “A Ghost of the Past” Audio. Listen to a reading of "A Ghost of the Past" by Meredith Lash-Dardia, MD. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics Cited byAnniversary 16 October 2012Volume 157, Issue 8Page: 595-596KeywordsChildrenChocolateEmotionsFallsMemoryResidencyShouldersWalking ePublished: 16 October 2012 Issue Published: 16 October 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Hospital Improvement in Time to Reperfusion in Patients With Acute Myocardial Infarction, 1999 to 2002
Authors: Robert L. McNamara, Jeph Herrin, Elizabeth H. Bradley, Edward L. Portnay, Jeptha P. Curtis, Yongfei Wang, David J. Magid, Martha Blaney, Harlan M. Krumholz
Journal: Journal of the American College of Cardiology (2005)
DREAM PATTERNS IN NARCOLEPTIC AND HYDRANENCEPHALIC PATIENTS
Authors: CHESTER M. PIERCE, JAMES L. MATHIS, J. T. JABBOUR
Journal: American Journal of Psychiatry (1965)

After 24 nights of study on hydranencephalic infants and their controls, it was concluded that REMs occur in hydranencephaly. Thus it is also concluded that although a cortex is not needed, the eye movements may be needed and thus may be associated with basic vegetative processes. Study on narcoleptics and their controls over 17 nights revealed no significant difference in blood glucose values in either deep sleep or dreaming sleep phases. Thus, some changes in nocturnal sleep phases of narcoleptics are not reflected by blood glucose alterations.
Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome
Authors: Mari Tanaka, Misako Asada, Atsuko Y. Higashi, Jin Nakamura, Akiko Oguchi, Mayumi Tomita, Sachiko Yamada, Nariaki Asada, Masayuki Takase, Tomohiko Okuda, Hiroshi Kawachi, Aris N. Economides, Elizabeth Robertson, Satoru Takahashi, Takeshi Sakurai, Roel Goldschmeding, Eri Muso, Atsushi Fukatsu, Toru Kita, Motoko Yanagita
Journal: Journal of Clinical Investigation (2010)

The glomerular basement membrane (GBM) is a key component of the filtering unit in the kidney. Mutations involving any of the collagen IV genes (COL4A3, COL4A4, and COL4A5) affect GBM assembly and cause Alport syndrome, a progressive hereditary kidney disease with no definitive therapy. Previously, we have demonstrated that the bone morphogenetic protein (BMP) antagonist uterine sensitization–associated gene-1 (USAG-1) negatively regulates the renoprotective action of BMP-7 in a mouse model of tubular injury during acute renal failure. Here, we investigated the role of USAG-1 in renal function in Col4a3–/– mice, which model Alport syndrome. Ablation of Usag1 in Col4a3–/– mice led to substantial attenuation of disease progression, normalization of GBM ultrastructure, preservation of renal function, and extension of life span. Immunohistochemical analysis revealed that USAG-1 and BMP-7 colocalized in the macula densa in the distal tubules, lying in direct contact with glomerular mesangial cells. Furthermore, in cultured mesangial cells, BMP-7 attenuated and USAG-1 enhanced the expression of MMP-12, a protease that may contribute to GBM degradation. These data suggest that the pathogenetic role of USAG-1 in Col4a3–/– mice might involve crosstalk between kidney tubules and the glomerulus and that inhibition of USAG-1 may be a promising therapeutic approach for the treatment of Alport syndrome.
The Importance of Being Grade 3: WHO 1999 Versus WHO 2004 Pathologic Grading
Authors: Fredrik Liedberg, Martin Lauss, Oliver Patschan, Mattias Aine, Gunilla Chebil, Magdalena Cwikiel, Helgi Engilbertsson, Sigurdur Gudjonsson, Petter Kollberg, Gottfrid Sjödahl, Wiking Månsson, David Lindgren, Mattias Höglund
Journal: European Urology (2012)
Interaction of Neisseria gonorrhoeae with classical complement components, C1-inhibitor, and a monoclonal antibody directed against the Neisserial H.8 antigen.
Authors: J E Schweinle, P J Hitchcock, A J Tenner, C H Hammer, M M Frank, K A Joiner
Journal: Journal of Clinical Investigation (1989)

Strains of Neisseria gonorrhoeae were used to evaluate bactericidal and opsonic properties of McAb 10 directed against the Neisserial outer membrane antigen, H.8. Gonococci were either serum resistant in the absence but serum sensitive in the presence, of McAb 10, or serum sensitive or serum resistant regardless of the presence of McAb 10. Strain JS3, which fell in the former category, was used in subsequent studies. C1 zymogen formed by reassociation of isolated C1 subunits was not directly activated by JS3 in the presence or absence of C1-inhibitor. JS3 thus was unable to directly activate the classical pathway independently of antibody. When purified classical pathway components were used to deposit C3 on JS3 in the absence of serum regulatory proteins or antibodies, added C1-inhibitor reduced C3 binding to background levels. When McAb 10 was present, C3 binding was unaffected by C1-inhibitor. Covalently bound, large molecular weight C3 alpha-chain-gonococcal complexes were disbanded by methylamine release of ester linkages. Released 125I-C3 migrated as C3b without degradation by gonococcal proteases. Purified classical components alone or McAb 10 alone facilitated JS3 killing by neutrophils; when combined, the two provided maximal killing. Levels of McAb 10 that only slightly increase C3 deposition on JS3 are bactericidal in serum and maximally opsonic in combination with purified classical pathway components.
Antibodies to cellular antigens in Sjögren's syndrome.
Authors: M A Alspaugh, E M Tan
Journal: Journal of Clinical Investigation (1975)

An extract of human lymphocytes from continous cell culture was used as the antigen source to detect antibodies in sera of patients with Sjögren's syndrome (SS). Using double diffusion in agarose, 85 per cent of a selected group of patients had precepating antibodies. Three precipitating antigen-antibody systems were detected and were shown to be different from those described previously in othe systemic rheumatic diseases. The SS precipitating antibodies were temporarily classified as precipitins, A, B, and C. SS patinets with sicca syndrome but without clinical rheumatoid arthritis had precipitin systems A and/or B, and SS patients with associated rheumatoid arthritis had precipitin system C. Serum reactants were demonstrated by immuno-electrophoresis to migrate in the gamma globulin region. The precipitating activity of the serum factors was not destroyed by treatment with 2-mercaptoethanol and was not removed by absorption of rheumatoid factor from the sera. The reactivity of the lympuocyte antigens was destroyed by treatment with trypsin but not by deoxyribonuclease or ribonuclease.
Ultrastructure and transmembrane potentials of cardiac muscle in the human anterior mitral valve leaflet.
Authors: A L Wit, J J Fenoglio, A J Hordof, K Reemtsma
Journal: Circulation (1979)

We studied the ultrastructure and electrophysiology of an anterior mitral valve leaflet obtained from the heart of a recipient of a cardiac transplant.The anterior leaflet of this human mitral valve contained atrial muscle in direct continuity with the left atrial myocardium.The muscle fibers were 3-6 , in diameter and contained atrial-specific granules.They were arranged in longitudinal bands of two or three muscle cells with intercalated discs at the cellular poles.These groups of cells were separated from one another by abun- dant loose connective tissue.The muscle fibers had maximum diastolic potentials of -61 ± 8 mV and action potentials with slow upstrokes (Vmax <15 V/sec) and low amplitudes (66 ± 6 mV) occurred during electrical stimulation of the valve.In the absence of electrical stimulation, valve muscle had phase 4 depolarization and initiated automatic impulses at a slow rate.The rate of impulse initiation was increased by epinephrine.During electrical stimulation, epinephrine also caused the appearance of delayed afterdepolarizations. Triggered sustained rhythmic activity could be elicited.Delayed afterdepolarizations and triggered activity were abolished by acetylcholine and verapamil.Our results indicate that cardiac muscle in the human mitral valve can initiate impulses and might be a site of origin of arrhythmias in the human heart.
Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function
Authors: Alexandra Mazharian, Jun Mori, Ying-Jie Wang, Silke Heising, Benjamin G. Neel, Steve P. Watson, Yotis A. Senis
Journal: Blood (2013)
Histologic atypia in clinically benign nevi
Authors: A. Bernard Ackerman
Journal: Journal of the American Academy of Dermatology (1991)

Susceptibility of Staphylococcus aureusTo the Editor: In Table II (J AM ACAD DERMATOL 1990;22:879-83) Leyden reported 100% susceptibility of Staphylococcus aureus to both cephalothin and cefoxitin.This report is questionable because 86.3% (not 100%) of the strains were susceptible to oxacillin.Footnote j of Table 2 in the approved standard "Performance Standards for Antimicrobial Disk Susceptibility Tests-Third Edition," published by the National Committee for Clinical Laboratory Standards, Villanova, Pennsylvania notes: "S.aureus exhibiting resistance to one of the penicillinase-resistant penicillins (MRSA) must be reported as resistant to cephalosporin-like antimicrobial agents, regardless of in vitro disk test results...." Presumably this is the origin of the document to which Dr. Leyden referred for his procedures.Accordingly, susceptibility of the strains of S. aureus to both cephalothin and cefoxitin should have been reported as 86.3% in both Table II and in the discussion.This same concept is presented in the current 1990 (fourth) edition of the standard. 2Dr. Leyden in his discussion does document the basis for interpretation of these strains as resistant to cephalosporins.
Chronic Idiopathic Neutropenia
Authors: Robert A. Kyle, James W. Linman
Journal: New England Journal of Medicine (1968)

In a study of 15 patients with severe absolute neutropenia of one to 19 years' duration there was no bone-marrow hypoplasia or splenomegaly, and the cause of the neutropenia was not apparent. These patients had no increase in the frequency of infections, and leukemia, lupus erythematosus and other serious disease did not develop. The neutropenia was chronic and did not respond to corticosteroids. This benign condition does not require therapy and should be recognized as such.
Consultant gets green light to sue his former employers for millions
Authors: C. Dyer
Journal: BMJ (2010)

A consultant dismissed for gross professional and personal misconduct has won the go-ahead from the Court of Appeal to sue his former employers for more than £4m (€4.8m; $5.8m) in compensation for ruining his career by using the wrong disciplinary process.

In their judgment, three senior judges overturned a high court ruling last year that Michael Edwards could sue only for salary he would have earned until the alternative disciplinary process was concluded, plus three months pay in lieu of notice.

Mr Edwards, former consultant trauma and orthopaedic surgeon with Chesterfield Royal Hospital NHS Foundation Trust in Derbyshire, was sacked …
Problems in Respiratory Medicine
Authors: Harry B. Greenberg
Journal: JAMA (1982)

How to handle children who are exposed to tuberculosis and how to treat their tuberculous parents are among the topics in this British physician's book. Sometimes British and American practices differ, but the similarities far outnumber the differences. Like us, Dr Forgacs considers nine months of multidrug treatment entirely adequate for all but the exceptional tuberculosis patient. Similarly, he finds relapse after antituberculosis treatment so rare that he does not recommend lengthy observation at a chest clinic. Forgacs takes up the recognition and treatment of bronchitis, sarcoidosis, pneumonia, asthma, and cancer. He cites from prospective study of British physicians to emphasize the correlation between cigarette smoking and carcinoma of the bronchus. Unforturnately, few untreated cancer patients survive longer than a year after diagnosis. The cancer cells may secrete hormones that initiate endocrine disorders, aggravating the patient's suffering and hastening his end. Finally, Forgacs warns his reader not to mistake an
Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent
Authors: Jacqueline M. Mason, Dan Chi-Chia Lin, Xin Wei, Yi Che, Yi Yao, Reza Kiarash, David W. Cescon, Graham C. Fletcher, Donald E. Awrey, Mark R. Bray, Guohua Pan, Tak W. Mak
Journal: Cancer Cell (2014)