tbuckley/cabot-search huggingface dataset:
1014. Adenovirus-Mediated MUC1-Driven Expression of the Sodium Iodide Symporter (NIS) in Pancreatic Tumors Provides for In Vivo Radioiodide Imaging and Therapy
Authors: Roisin M. Dwyer, Elizabeth R. Bergert, Michael K. O'Connor, Sandra J. Gendler, John C. Morris
Journal: Molecular Therapy (2005)

Top of pageAbstract
Pancreatic cancer is the fourth leading cause of cancer death in the United States. It is highly aggressive with no effective chemotherapy available for metastatic disease. The Sodium Iodide Symporter (NIS) is a transmembrane glycoprotein responsible for uptake of iodide into cells. The presence of NIS in thyroid cells has permitted non-invasive diagnostic imaging and ablation of thyroid tumors using radiolabeled iodide. A previous study from this laboratory reported adenovirus-mediated MUC1-driven expression of the NIS gene in breast cancer cells. The use of the MUC1 promoter to drive NIS expression resulted in selective tumor specific expression of the protein. MUC1 is overexpressed in many tumor types including breast, pancreatic, lung, prostate and ovarian. The incidence of MUC1 overexpression in pancreatic tumors has been reported to be as high as 90%. In this study the replication-deficient Ad5-MUC1-NIS construct was used to infect MUC1-positive pancreatic cancer cells both in vitro and in vivo, to investigate the potential for radioiodide imaging and ablation of this disease. In vitro studies revealed a 43-fold increase in iodide uptake in NIS transduced cells compared to controls. Western blot and immunohistochemical analysis confirmed NIS protein expression and membrane localization. MUC1 negative pancreatic cells transduced with the construct did not express NIS, which confirmed the specificity of the construct. In vivo studies were carried out in tumor-bearing nude mice. Intratumoral injection of virus was followed 4 days later by intraperitoneal injection of 0.5mCi 123I. Serial images were then taken of the animals from 1-48 hrs following iodide administration. This revealed clear images of the NIS transduced tumors, with optimal uptake observed 1hr after iodide administration. Tumors infected with a promoterless virus did not concentrate iodide. Studies investigating the potential for treatment of pancreatic cancer using therapeutic doses of 131I are ongoing. The ability to target NIS expression to pancreatic cancer, which has such limited treatment options, may be highly beneficial. This study is an important initial step investigating the potential for use of radiolabeled iodide as a systemic therapeutic agent in pancreatic cancer treatment. The results presented here clearly demonstrate that the application of this virus is not limited to one tumor type, but may provide for imaging and therapy of a range of MUC1-positive malignancies.
Thrombocytosis, circulating platelet aggregate, and neurological dysfunction
Authors: B. James
Journal: BMJ (1980)

who continued treatment with tamoxifen alone did not have a response.We agree that tamoxifen-induced hyper- calcaemia probably is not uncommon, but as yet there is no firm evidence to support the suggestion that induced hypercalcaemia is indicative of a good response to tamoxifen or other additive hormones used in the treatment of breast cancer.
House of Lords is to consider bill on assisted suicide
Authors: C. Dyer
Journal: BMJ (2014)

A bill to legalise physician assisted suicide in England and Wales has been tabled again in the House of Lords, and this time peers are expected to have a chance to vote on the proposals.

The Assisted Dying Bill was introduced last year by Charles Falconer, a former Labour lord chancellor, but timetabling problems prevented it from getting any further.1

The reintroduced bill could have a second reading debate …
RECENT THERAPEUTIC APPLICATION OF THE VALERIANATES OF CREOSOTE AND GUAIACOL.
Authors: J. W. WAINWRIGHT
Journal: JAMA (1898)

It can be safely assumed that the marvelous evidences of progress which the world has witnessed during the last quarter of a century in the science of medicine, especially in the department of clinical medicine and surgery, in very great measure may be justly attributed to the discovery of the relationship which exists either directly or indirectly between certain diseases and a comparatively small group of micro-organisms which are now known to be pathogenic. Out of this application of bacteriology or microscopic botany to the practice of medicine has been developed our present aseptic and antiseptic methods of wound treatment and also our therapeutics of many infectious diseases. The knowledge that we now have of the causes of infection in wounds we owe to the genius of Lister, who has taught us also how we may securely guard against suppuration and other germinduced pathologic conditions. Similarly Pasteur, Koch, Klebs and
Suspected Adverse Effects of Drugs
Authors: Harold D. Kautz, Rodney P. Swinn, George H. Berryman
Journal: JAMA (1964)

In the evaluation of suspected drug reactions it is imperative to consider whether the symptoms and findings are primarily related to the patient, the disease, the procedure, or the medication. The ultimate status of therapeutic agents depends on a fair appraisal and reporting of their limitations as well as their effectiveness. Suspected drug reactions deserve careful study to avoid erroneous conclusions concerning cause and effect. Accurate and complete information is needed by drug manufacturers in order to safeguard the use of drug products by the physician.
Racial Differences Pertaining to a Belief about Lung Cancer Surgery: Results of a Multicenter Survey
Authors: Mitchell L. Margolis, Jason D. Christie, Gerard A. Silvestri, Larry Kaiser, Silverio Santiago, John Hansen-Flaschen
Journal: Annals of Internal Medicine (2003)

Background: Patients at the Philadelphia Veterans Affairs Medical Center frequently voice concern that air exposure during lung cancer surgery might cause tumor spread. Several African-American patients asserted that this belief was common in the African-American community. Objective: To assess the prevalence of the belief that air exposure during lung cancer surgery might cause tumor spread and gauge the influence of this belief on the willingness of African-American and white patients to have lung cancer surgery. Design: Prospective questionnaire survey. Setting: Philadelphia Veterans Affairs Medical Center and University of Pennsylvania, Philadelphia, Pennsylvania; Los Angeles Veterans Affairs Medical Center, Los Angeles, California; and Medical University of South Carolina, Charleston, South Carolina. Patients: 626 consecutive patients in pulmonary and lung cancer clinics. Measurements: None. Results: 38% of patients (61% of whom were African American and 29% of whom were white) stated that they believe air exposure at surgery causes tumor spread. The most significant predictor of belief was African-American race (odds ratio, 3.5 [95% CI, 1.9 to 6.5]), even after controlling for other relevant variables in a multivariable analysis. Nineteen percent of African Americans stated that this belief was a reason for opposing surgery, and 14% would not accept their physicians' assertion that the belief is false. These rates were also statistically significantly higher among African-American than white patients. Conclusions: Belief in accelerated tumor spread at surgery is prevalent among general pulmonary outpatients and lung cancer clinic patients facing lung surgery, particularly among African-American patients. Our findings may pertain to key racial disparities in lung cancer surgery and survival rates and suggest that culturally sensitive physician training or outreach programs directed at disparate beliefs and attitudes may help to address racial discrepancies in health care outcomes.
Why Do Elderly Migrate From High Altitudes?
Authors: Gregory S. Slater
Journal: JAMA (1985)

<h3>To the Editor.—</h3> In the recent article, "Migration of the Elderly From High Altitudes in Colorado,"<sup>1</sup>in the June 7 issue, statistical evidence shows that the elderly migrate from high-altitude areas to lower-altitude areas with increasing numbers as they get older. It is stated that two medical problems related to this migration are heart and lung disease and that many of these elderly people must travel up to 100 miles to see a medical specialist. I have some reservation as to the validity of the study. I am wondering whether these people "change their residence" because of their isolation and not because of the altitude. It is not clear to me whether these people migrate to be closer to specialized medical care, relatives, a warmer climate, or an urban environment. To be scientific about this article, you would have to do a similar study on the migration of elderly
Abstract 1499: Role of <i>Twist</i> for maintenance of EMT in colon cancer cell .
Authors: Hye Ryeon Kim, SoYoung Kim, Young Ae Baik, Hye Kyung Hong, Woo Yong Lee, Yong Beom Cho
Journal: Cancer Research (2013)

Abstract Epithelial-mesenchymal transition or transformation (EMT) is a process characterized by loss of cell adhesion, repression of E-cadherin expression, and increased cell motility. Epithelial-mesenchymal transition (EMT) confers tumor cells with metastatic dissemination, cancer stem cell-like characters and drug resistance. However, the molecular mechanism for metastatic dissemination remains unclear. Initiation of metastasis involves invasion, which has many phenotypic similarities to EMT, including a loss of cell-cell adhesion mediated by E-cadherin repression and an increase in cell mobility. In this study, we induced EMT in colon cancer cell line LoVo with expression of Twist, a key transcriptional factor of EMT. The metastasis associated with EMT was determined E-cadherin, vimentin and β-catenin protein expression by western blot and morphological changes associated with EMT in these cells. We found that expression of Twist induced a morphological change associated with EMT in these cells. We also found that the E-cadherin was significantly decreased in Twist-overexpressing cells LoVo. Interestingly, we showed that β-catenin was activated in these Twist-overexpressing cells. Our results indicate that activation of β-catenin is required for the sustention of EMT-associated metastasis dissemination. Citation Format: Hye Ryeon Kim, SoYoung Kim, Young Ae Baik, Hye Kyung Hong, Woo Yong Lee, Yong Beom Cho. Role of Twist for maintenance of EMT in colon cancer cell . [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1499. doi:10.1158/1538-7445.AM2013-1499
The Frontal Plane Vectorcardiogram in Old Inferior Myocardial Infarction
Authors: ELIOT YOUNG, CONGER WILLIAMS
Journal: Circulation (1968)

The early part of the frontal plane QRS loop (Frank lead system) was analyzed in 100 consecutive patients with an old inferior myocardial infarction. In order to be included in this study, all cases had to fulfill, at some time, Myers' classical ECG criteria for the diagnosis. The vectorcardiogram was made months to years after the patient's original acute episode. Several scalar and planar parameters, pertaining to these frontal plane early QRS vectors, were analyzed. As a result of this analysis and in order to prevent overlap with values found in 315 normal control subjects, VCG criteria, based on the interrelationships of several of these parameters, were proposed for the diagnosis of old inferior myocardial infarction. Pitfalls in the use of only scalar or planar analyses were pointed out. In 90 of the 100 cases the diagnosis was made on the basis of the proposed VCG criteria. However, the ECG made at the same time fulfilled Myers' or Goldberger's classical criteria in only 42 of the 100 cases. All cases diagnosed from the ECG were also diagnosed from the VCG.
Familial Varices of the Small and Large Bowel
Authors: S. Morini, F. Caruso, P. De Angelis
Journal: Endoscopy (1993)

Two familial cases of varices confined to the small and the large bowel are reported. Both patients were diagnosed in advanced age because of recurrent intestinal bleeding. The study of the entire gastrointestinal tract revealed an unexpected wide involvement and the primary nature of the varices. Moreover, both patients had coexistent adenomatous polyps.
Heavy metal contamination from geothermal sources.
Authors: J E Sabadell, R C Axtmann
Journal: Environmental Health Perspectives (1975)

Liquid-dominated hydrothermal reservoirs, which contain saline fluids at high temperatures and pressures, have a significant potential for contamination of the environment by heavy metals. The design of the power conversion cycle in a liquid-dominated geothermal plant is a key factor in determining the impact of the installation. Reinjection of the fluid into the reservoir minimizes heavy metal effluents but is routinely practiced at few installations. Binary power cycles with reinjection would provide even cleaner systems but are not yet ready for commercial application. Vapor-dominated systems, which contain superheated steam, have less potential for contamination but are relatively uncommon. Field data on heavy metal effluents from geothermal plants are sparse and confounded by contributions from "natural" sources such as geysers and hot springs which often exist nearby. Insofar as geothermal power supplies are destined to multiply, much work is required on their environmental effects including those caused by heavy metals.
A Zebrafish Model of Human Barth Syndrome Reveals the Essential Role of Tafazzin in Cardiac Development and Function
Authors: Zaza Khuchua, Zou Yue, Lorene Batts, Arnold W. Strauss
Journal: Circulation Research (2006)

Barth syndrome is an X-linked disorder characterized by cardiomyopathy, skeletal myopathy, neutropenia, organic aciduria, and growth retardation caused by mutations in tafazzin. The sequence similarity of tafazzin to acyltransferases suggests a role in mitochondrial phospholipid metabolism. To study the role of tafazzin in heart function and development, we created a knockdown zebrafish model. Zebrafish tafazzin mRNA is first evident at 7 hours post-fertilization (hpf). At 10 and 24 hpf, tafazzin mRNA is ubiquitous, with highest levels in the head. By 51 hpf, expression becomes cardiac restricted. The tafazzin knockdown created by antisense morpholino yolk injection resulted in dose-dependent lethality, severe developmental and growth retardation, marked bradycardia and pericardial effusions, and generalized edema, signs that resemble human Barth syndrome heart failure. This knockdown phenotype was rescued by concomitant injection of normal tafazzin mRNA. Abnormal cardiac development, with a linear, nonlooped heart, and hypomorphic tail and eye development proves that tafazzin is essential for overall zebrafish development, especially of the heart. The tafazzin knockdown zebrafish provides an animal model similar to Barth syndrome to analyze the severity of human mutants and to test potential treatments.
The restorative logic of punishment: Another argument in favor of weak selection
Authors: Nicolas Baumard
Journal: Behavioral and Brain Sciences (2012)

Abstract Strong reciprocity theorists claim that punishment has evolved to promote the good of the group and to deter cheating. By contrast, weak reciprocity suggests that punishment aims to restore justice (i.e., reciprocity) between the criminal and his victim. Experimental evidences as well as field observations suggest that humans punish criminals to restore fairness rather than to support group cooperation.
Dose-Related Hemodynamic and Electrocardiographic Effects of the Calcium Promoter BAY y 5959 in the Presence or Absence of Congestive Heart Failure
Authors: Michel F Rousseau, Pierre-E Massart, Christian van Eyll, Jean Etienne, Sylvie Ahn, Hans G Schaefer, Wolfgang Mueck, Martin Bornemann, Hubert Pouleur
Journal: Journal of the American College of Cardiology (1997)
Dissimilarities of Digoxin
Authors: Stephen E. Goldfinger
Journal: New England Journal of Medicine (1971)

Every physician struggles to come up with the "proper digitalizing dose" at some point in his career. At times, it is to survive an internship interview; on other occasions, someone else's future is at stake. In the article by Lindenbaum et al. in the current issue of the Journal, there is information to suggest that the brand of digoxin employed may at times have as much to do with such ultimate outcomes as our most sophisticated calculations concerning dose and frequency. Serum digoxin concentrations for five hours after the oral administration of 0.5 mg of this drug showed an . . .
Gaviscon maker is accused of rigging the market
Authors: Z. Kmietowicz
Journal: BMJ (2010)

The household products company Reckitt Benckiser UK is being investigated by the Office of Fair Trading (OFT) over whether it manipulated the market for its heartburn drug Gaviscon.

The OFT alleges that the company sought to restrict competition to its Gaviscon brand of compound alginate preparations when it withdrew and delisted its Gaviscon Original Liquid from the NHS prescription channel in 2005 and introduced Gaviscon Advance, which was protected by …
Coronary Artery Spasm
Authors: ROBERT J. LUCHI
Journal: Annals of Internal Medicine (1979)

Coronary artery spasm is an important pathogenetic mechanism in some forms of myocardial ischemic disease. Factors that may be important in the genesis of spasm include the autonomic nervous system, prostaglandins, endoperoxides, thromboxanes, and the calcium availability to the contractile apparatus. Spasm results in myocardial ischemia with attendant chest pain and electrocardiographic and hemodynamic changes; it is the primary pathogenetic mechanism in Prinzmetal's variant angina and has been found in association with classic angina pectoris and acute myocardial infarction. Diagnosis of coronary artery spasm is firmly made only by coronary angiography. Treatment includes the use of both short- and long-acting nitrates and the slow-channel blocking agents such as verapamil, nifedipine, and perhexiline.
CHANGES IN INCIDENCE AND MORTALITY RATES OF ISCHEMIC AND NON-ISCHEMIC HEART FAILURE. A 10-YEAR STUDY
Authors: Yingzi Deng, Abel E. Moreyra, William J. Kostis, John Pantazopoulos, Nora M. Cosgrove, Alan C. Wilson, John B. Kostis
Journal: Journal of the American College of Cardiology (2010)
Detection of cytomegalovirus antigens in phagocytosed serum complexes from a patient with rheumatoid arthritis, vasculitis, peripheral neuropathy, cutaneous ulceration, and digital gangrene.
Authors: J N McCormick, D Wojtacha, E Edmond
Journal: Annals of the Rheumatic Diseases (1992)

A patient with rheumatoid arthritis, vasculitis, peripheral neuropathy, cutaneous ulceration, and digital gangrene was studied. Circulating immune complexes were detected by C1q binding although serum complement levels were within the normal range. Immunofluorescent staining of buffy coat cells with specific antisera showed the presence of IgG and IgM in phagocytosed inclusions but complement C3 was not detected. A monoclonal antibody specific for cytomegalovirus detected antigens in phagocytosed inclusions on one occasion. These results may suggest that cytomegalovirus antigens are a hitherto unidentified component of serum complexes in patients with rheumatoid arthritis and may contribute to the pathogenesis of the vasculitic complications of rheumatoid arthritis by participating in immune complex formation.
WEIGHTED TEMPERATURE ELEVATION: A MEASURE OF SKIN REACTIVITY.
Authors: DEBORAH KAPLAN, W. KOCH
Journal: British Journal of Dermatology (1965)

Journal Article WEIGHTED TEMPERATURE ELEVATION: A MEASURE OF SKIN REACTIVITY. Get access DEBORAH KAPLAN, M.Sc, Ph.D., DEBORAH KAPLAN, M.Sc, Ph.D. Department of Microbiology and Public Health, The Chicago Medical School, Chicago, Illinois Search for other works by this author on: Oxford Academic Google Scholar W. KOCH, M.D., Ph.D. W. KOCH, M.D., Ph.D. Department of Microbiology and Public Health, The Chicago Medical School, Chicago, Illinois Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 77, Issue 12, 1 December 1965, Pages 650–652, https://doi.org/10.1111/j.1365-2133.1965.tb14596.x Published: 01 December 1965
SYNTHESIS, ASSEMBLY, AND SECRETION OF GAMMA GLOBULIN BY MOUSE MYELOMA CELLS
Authors: Reuben Baumal, Michael Potter, Matthew D. Scharff
Journal: The Journal of Experimental Medicine (1971)

The synthesis, assembly, and secretion of the three major subclasses of mouse IgG has been examined in 14 myeloma tumors and two cultured cell lines as well as in the cells from the popliteal lymph nodes of immunized mice. The total amount of IgG synthesized was between 15 and 43% of the cytoplasmic proteins made during a 15 min period. H2 and H2L were the major precursors of IgG2a and IgG1 but, in all of the tumors, HL was also an intermediate. In contrast, HL was a major precursor of IgG2b. Most of the noncovalent and covalent assembly of IgG occurred after release of the newly synthesized H and L chains from the polyribosomes and assembly was not completed until 10 min or more after the synthesis of the polypeptide chains.
A Rare Injury of the Shoulder-Joint
Authors: G. Foote
Journal: BMJ (1875)

Dyce Duckworth contri- buted one of the most able papers that have been written within the last few years.upon the nature and treatment of alopecia areata.MIuch evidence has been adduced on both sides as to its parasitic or non- parasitic origin; but, notwithstanding, the majority of those who have studied the microscopical characters of the altered hairs obtainable in this affection do certainly speak most emphatically, and I believe with truth, in favour of its being independent of any fungus-element.That this disease may occur associated with other parasitic affections-tinea tonsurans, for example-there can be no possible doubt; but the fact
NI-11 * THE POTENTIAL ROLE OF 18F-FDOPA PET IMAGING IN THE EVALUATION OF LOW-GRADE GLIOMAS
Authors: C. Carapella, A. Chiaravalloti, V. Villani, A. Vidiri, F. Piludu, I. Terrenato, A. Fabi, O. Schillaci, A. Pace, R. Floris
Journal: Neuro-Oncology (2014)

Brain tumors have been widely evaluated using the 3,4-dihydroxy-6-18fluoro-L-phenylalanine (18F-FDOPA) PET imaging. The aim of the study is to evaluate the role of 18F-FDOPA PET in low-grade glioma (LGG). We enrolled 60 patients (37 males and 23 females) affected with LGG; 23% were newly diagnosed, 45% were studied during treatment; and 32% were observed out of treatment during a periodic follow-up. All patients underwent 18F-FDOPA PET and MRI examination; both FLAIR and contrast-enhanced T1-weighted sequences were considered for the response assessment in according to RANO criteria. The PET images were interpreted as positive when the lesion presented definite tracer accumulation considering background and controlateral site. The slices with a maximal 18F-FDOPA uptake in the ROI were chosen for quantitative measurement of metabolic activity of the tracer [standardized uptake value (SUV)]. The concordance between MRI and 18F-FDOPA PET was evaluated measuring the unweighted kappa statistic and its relative 95% Confidence interval (95%CI). The Kappa statistic for the whole sample was equal to 0.301 (95%CIs from 0.21 to 0.40) showing a fair concordance between the two tests in terms of diagnostic ability. We found a good correlations between residual volume and SUV max (r = 0.435, p = 0.002 by Spearman Rank Correlation Coefficient), indicating that the greater the residual volume, higher the SUV max is. Also multivariate analysis documented that a SUV max greater than 1.75 represents the only independent predictor of disease progression (HR = 4.59, 95% CIs from 0.99 to 21.31, p = .054). This implies that a patient with a SUV max higher than 1.75 yielded an almost 5-fold increased risk of disease progression, regardless of its clinical and MRI characteristics. Present results confirm that 18F-FDOPA PET imaging may assume a relevant role mainly in the prognostic assessment of patients affected with primary and recurrent LGG.