tbuckley/cabot-search huggingface dataset:
IT contractor leaves NHS programme on electronic patient records
Authors: Mike Cross
Journal: BMJ (2008)

A £900m (€1150m; $1770m) contract with an IT services firm is the latest part of the £13bn programme that started five years ago to computerise the NHS in England to go awry.

NHS Connecting for Health, the agency that runs the programme, has said that it will issue a termination notice to Fujitsu, “the local service provider” responsible for installing and running electronic patient record systems in southern England, from Cornwall to Kent but excluding London. The decision has followed months of renegotiations of a 2004 contract.

The agency would not say who would replace Fujitsu. “Work has started immediately on planning the necessary arrangements.” It has already …
Remarks on Sclerema &amp; OEdema Neonatorum
Authors: J. W. Ballantyne
Journal: BMJ (1890)

stated that she had had pains in the abdomen off and on ever since she left, and that she had had only thre3 fits.On the even- ing of the 9th she had crab for tea; and in the night woke up in severe pain.The pain was general over the abdomen, but worse on the left side, and had a "dragging" character.The abdomen became swollen and tender.The bowels had not been relieved since the 7th, and she had not passed water since the pain came on.On admission (about noon) the patient was writhing in appa- rently great agony, groaning, and frequently retching.The legs were drawn up, and respiration was entirely thoracic.The abdo- men was much and uniformly distended, and extremely tender to the touch, especially in the left iliac region.She was examined under chloroform, and had a fit while it was being administered, but nothing unnatural was discovered in the abdomen.Tongue dry; pulse 75, full; temperature 100°.She was anesthetic throughout the whole of the right side.Water removed by catheter.The next day (the 11th) she was much better.Her tongue was moister, her temperature was normal, and she passed water voluntarily.She had lost her sickness, and her abdomen was less swollen and less tender, and her breathing was more abdominal
Carbamazepine-induced hypersensitivity syndrome associated with transient hypogammaglobulinaemia and reactivation of human herpesvirus 6 infection demonstrated by real-time quantitative polymerase chain reaction
Authors: Y. Aihara, S-I. Ito, Y. Kobayashi, Y. Yamakawa, M. Aihara, S. Yokota
Journal: British Journal of Dermatology (2003)

Summary Drug-induced hypersensitivity syndrome (HS) is a rare but severe disease with multiorgan failure. Many different precipitating factors have been reported, but the pathophysiology of HS remains unknown. However, the association of the human herpesvirus (HHV) family, particularly of HHV-6, has recently been reported in patients with HS. We report a 14-year-old boy who was diagnosed as having carbamazepine-induced HS based on the clinical course, laboratory data and results of drug-induced lymphocyte stimulation tests. In addition, the reactivation of HHV-6 was demonstrated by real-time quantitative polymerase chain reaction and by significantly increased levels of the specific antibody in his paired sera. Furthermore, transient hypogammaglobulinaemia was detected in the early stage of the disease. In addition, serum levels of interferon-γ, interleukin (IL)-6, IL-5 and eosinophil cationic protein, which were increased on admission, decreased dramatically after steroid therapy. This is the first report of carbamazepine-induced HS associated with reactivation of HHV-6, transient hypogammaglobulinaemia, increased serum levels of inflammatory cytokines and activated eosinophils. This case might contribute to the understanding of the pathophysiology of HS.
Effects of withdrawal of co-danthramer on use of laxatives in a district general hospital.
Authors: D. R. Upton, J. K. Taylor, G. K. Holmes, J. W. Poston
Journal: BMJ (1988)

weakness are both associated, independently of other influences, with an increased risk of hip fracture in elderly people.This points to the importance of maintaining physical activity in the day to day lives of old people.
God would be a costly accident: Supernatural beliefs as adaptive
Authors: Dominic D. P. Johnson
Journal: Behavioral and Brain Sciences (2009)

Abstract I take up the challenge of why false beliefs are better than “cautious action policies ” (target article, sect. 9) in navigating adaptive problems with asymmetric errors. I then suggest that there are interactions between supernatural beliefs, self-deception, and positive illusions, rendering elements of all such misbeliefs adaptive. Finally, I argue that supernatural beliefs cannot be rejected as adaptive simply because recent experiments are inconclusive. The great costs of religion betray its even greater adaptive benefits – we just have not yet nailed down exactly what they are.
Cilostazol inhibits leukocyte integrin Mac-1, leading to a potential reduction in restenosis after coronary stent implantation
Authors: Teruo Inoue, Toshihiko Uchida, Masashi Sakuma, Yoshitaka Imoto, Yasushi Ozeki, Yukio Ozaki, Yutaka Hikichi, Koichi Node
Journal: Journal of the American College of Cardiology (2004)
Myocardial metabolism for the toxicologist.
Authors: R G Merin
Journal: Environmental Health Perspectives (1978)

Drug effects on myocardial contractile function are obviously of considerable practical importance for the toxicologist. The basic mechanism of such actions must reside at some point in the metabolism of cardiac muscle. Interference in the liberation of energy from the fuels that the heart uses may be implicated. It is possible that drugs may interfere with the storage (conservation) of that energy as the high energy phosphates (ATP and CP). Finally, the utilization of that stored energy by the contractile proteins themselves may be altered. The latter process is highly dependent on intracellular calcium ion kinetics. Anesthetic drugs, which produce reversible depression of myocardial contractile function is a dose-dependent fashion, have been shown to interfere to some extent with all three processes. However, the most important mechanism probably involves utilization of energy and intracellular calcium ion movement. A basic knowledge of the biochemistry of cardiac muscle is necessary for the understanding of drug action and toxicity at the subcellular level.
THE APOCRINE SWEAT GLANDS
Authors: Arthur G. Schouch
Journal: JAMA (1960)

<h3>To the Editor:—</h3> This time it is no accolade. Please refer to the first line, left-hand column,The Journal, Sept. 10, page 174. I quote: "The eyelids and the middle ear (ceruminous glands secrete the yellow pigment in ear wax)." Even an erudite, astute and educated editor occasionally stumps his toe. As I recall, the middle ear contains the incus, the stapes, and the malleus. Tis, of course, a minor mistake in the editorial entitled "The Sweat That Smells." Since we both love and admire the Lancet, I'll bet they would have entitled this editorial, "The Sweat That Stinks." Yes, I stumped my toe.—Ed.
Hypotension During Sham Apheresis in a Patient Taking ACE Inhibitors-Reply
Authors: Tetsuzo Agishi
Journal: JAMA (1995)

<h3>In Reply.</h3> —Marked elevation of bradykinin concentration in contact with a polysulfone plasma separator, the membrane material of which is also charged negative, has been reported by Koga et al.<sup>1</sup>Administration of an ACE inhibitor during LDL adsorption with a DSC must be done with extreme care, according to an official notice from the Japanese Ministry of Health and Welfare, distributed October 21, 1993. Recently, Sinzinger et al<sup>2</sup>reported data concluding that use of ACE inhibitors with a shorter half-life or withdrawal of the compounds more than 24 hours before LDL apheresis is not safe enough. As we noted in our original letter, the protease inhibitor nafamostat mesylate (FUTHAN, Torii Pharmaceutical Co Ltd, Tokyo, Japan), which is widely used as an anticoagulant for extracorporeal circulation but currently commercially available only in Japan, is known to inhibit release and accumulation of bradykinin even with concomitant administration of ACE inhibitors.
A subcortical inhibitory signal for behavioral arrest in the thalamus
Authors: Kristóf Giber, Marco A Diana, Viktor Plattner, Guillaume P Dugué, Hajnalka Bokor, Charly V Rousseau, Zsófia Maglóczky, László Havas, Balázs Hangya, Hendrik Wildner, Hanns Ulrich Zeilhofer, Stéphane Dieudonné, László Acsády
Journal: Nature Neuroscience (2015)
Preparation and purification of lymphocytes from the epithelium and lamina propria of murine small intestine.
Authors: M D Davies, D M Parrott
Journal: Gut (1981)

Existing methods for the production of lymphocytes from the small intestine have proved unsatisfactory when applied to the mouse. We report here a new method for the production of highly pure suspensions of lymphoid cells from the epithelial layer and lamina propria of mouse small intestine. The production and purification methods are described in detail. At least ten million lymphocytes are obtainable from each small intestine from either the epithelium or lamina propria and the cell suspensions are shown to be little contaminated by non-lymphoid cells. Preliminary analysis of the two cell types indicates that they belong either to two separate populations or to one population in very different stages of differentiation. The use of purified lymphoid cells from the epithelium and lamina propria of the small intestine may enable examination of the generation of cytotoxicity towards gut epithelial cells; this may be important in the development of inflammatory bowel diseases.
Suppression of Immediate and Late Anti‐IgE‐Induced Skin Reactions by Topically Applied Alcohol/Onion Extract
Authors: Walter Dorsch, Johannes Ring
Journal: Allergy (1984)

In a double blind study, alcohol/onion extract (5% ethanol) was injected simultaneously with 20 IU and 200 IU rabbit anti‐human‐IgE intradermally in 12 adult volunteers (6 atopics, 6 non‐atopics). Diameters of wheals and flares were measured 10 mm after and compared with control sites challenged with 20 IL1 and 200 IL1 anti‐IgE in a 5% ethanol solution. The skin sites were then treated epidermally with 45% alcohol/onion extract and 45% ethanol under occlusion. Diameters of late cutaneous reactions were measured hourly. Oedema formation was clinically estimated according to an arbitrary scale and skin thickness measured with a calliper. In the onion‐treated skin sites the wheal areas were significantly reduced (20 IU: control: 108 ± 53 mm 2 : onion 69 ± 42 mm 2 , P &lt; 0.05;, 200 IL anti‐lgE: control: 152 ±, 25 mm 2 , onion: 138 ±, 26 mm 2 , P &lt; 0.02). The oedema formation during the late phase skin reaction was markedh depressed (P &lt; 0.005 at 2 h, P &lt; 0.01 at 4 and 6 h, P &lt; 0.02 at 8 h). The extent of late skin reactions was slightly, but not significantly reduced. Obviously. onions contain pharmacologically active substances with anti‐inflammatory and or allergic properties.
Abstract LB-11: Clinical and genetic analysis of Peutz-Jeghers syndrome patients in Taiwan
Authors: Meng Tzu Weng, Shu Chen Wei
Journal: Cancer Research (2010)

Abstract Background/Purpose: Peutz-Jeghers syndrome (PJS) is an autosomal dominant inherited disorder characterized by intestinal hamartomatous polyps and mucocutaneous pigmentation. Recently, germline mutations in the LKB1 gene have been reported to underlie PJS. The gene encoding this serine/threonine kinase is located at 19p 13.3. The aim of this study was to investigate the clinical and genetic characteristics of PJS patients in Taiwan. Methods: We searched the database in the National Taiwan University Hospital, a tertiary medical center in Taiwan, between January 1990 and November 2005. Patients’ clinical information, demographic data, endoscopic pictures, and outcome details for these cases were reviewed and analyzed. After obtaining informed consent, DNA and RNA were extracted from peripheral blood mononuclear cells and the LKB1 gene was sequenced. Results: A total of 14 non-related patients fulfilling the diagnostic criteria of PJS were included, and seven of them had genetic analysis performed. Mucocutaneous pigmentation was the most frequent presentation. Hamartomas occur most commonly in the small intestine (86%). The frequent abdominal complications include intussusceptions and gastrointestinal bleeding. Four germline mutations were found (57.1%). Three resulted in stop codons at codon 60, 162 (novel mutation), and 308. The fourth mutation was a missense mutation at codon 239 (novel mutation). Conclusions: Compared to other reports, PJS patients in Taiwan tended to have more extensive polyps in the GI tract, causing intussusceptions as the most common abdominal symptoms. The genetic mutations in the LKB1 gene were identified in 57% of the probands in Taiwan. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-11.
1008-187 Effect of pravastatin on endothelial function in human immunodeficiency virus-infected persons on protease inhibitor-containing antiretroviral combination therapy
Authors: David Hurlimann, Remy Chenevard, Frank Ruschitzka, Jorg Muntwyler, Thomas Luscher, Georg Noll, Markus Flepp, Bruno Ledergerber, Rainer Weber
Journal: Journal of the American College of Cardiology (2004)
Comparison of CKMB and troponin T in stratifying risk for adverse outcomes in a chest pain observation unit
Authors: S.A. DeLuca, E.S. McErlean, F. Van Lente, W.F. Peacock, M.T. Craig, J. DelValle, J.S. Rao, S.E. Nissen
Journal: Journal of the American College of Cardiology (1998)
TESTS IN SPLENOMEGALY
Authors: Horace E. Campbell
Journal: JAMA (1930)

<h3>To the Editor:</h3> —I should like to call the attention of the profession in America to two simple laboratory tests applicable to cases of splenomegaly. Brahmachari (<i>Indian M. Gaz</i>.<b>52</b>:319 [Sept.], 429 [Dec.] 1917; Kala-Azar and Its Treatment, ed. 2, 1920) reported in 1917 that a copious precipitate was frequently observed when the serum of kala-azar patients was mixed with an excess of distilled water. Napier (<i>Indian M. Gaz</i>.<b>56</b>:338, 1921;<b>58</b>:104 [March] 1923) in 1921 further reported that, when 2 drops of liquor formaldehydi is added to 1 cc. of clear serum of kala-azar patients, opacity and jellification occur within half an hour. These two tests have subsequently been found to be positive in cases of schistosomiasis (Meleney, H. E., and Wu, Hsien:<i>China M. J</i>.<b>38</b>:357 [May] 1924). The phenomena have been attributed to an increase in the serum globulin in these patients (Brahmachari,
Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression
Authors: Junichiro Miake, Eduardo Marbán, H. Bradley Nuss
Journal: Journal of Clinical Investigation (2003)

The inward rectifier current IK1 is tightly regulated regionally within the heart, downregulated in heart failure, and genetically suppressed in Andersen syndrome. We used in vivo viral gene transfer to dissect the role of IK1 in cardiac repolarization and maintenance of the resting membrane potential (RMP) in guinea pig ventricular myocytes. Kir2.1 overexpression boosted Ba2+-sensitive IK1 by more than 100% (at –50mV), significantly shortened action potential durations (APDs), accelerated phase 3 repolarization, and hyperpolarized RMP compared with control cells (nongreen cells from the same hearts and green cells from GFP-transduced hearts). The dominant-negative Kir2.1AAA reduced IK1 by 50–90%; those cells with less than 80% reduction of IK1 exhibited prolonged APDs, decelerated phase 3 repolarization, and depolarization of the RMP. Further reduction of IK1 resulted in a pacemaker phenotype, as previously described. ECGs revealed a 7.7% ± 0.9% shortening of the heart rate–corrected QT interval (QTc interval) in Kir2.1-transduced animals (n = 4) and a 16.7% ± 1.8% prolongation of the QTc interval (n = 3) in Kir2.1AAA-transduced animals 72 hours after gene delivery compared with immediate postoperative recordings. Thus, IK1 is essential for establishing the distinctive electrical phenotype of the ventricular myocyte: rapid terminal repolarization to a stable and polarized resting potential. Additionally, the long-QT phenotype seen in Andersen syndrome is a direct consequence of dominant-negative suppression of Kir2 channel function.
Letter: Price of prostatectomy.
Authors: G F Abercrombie
Journal: BMJ (1974)

parent.In your leading article (17 August, p. 430) you express an opinion that was discarded by most ophthalmologists in Bri- tain many years ago.Your support for this del-ayed surgery is lperpetuating an idea which results in many children not developing any form of binocular vision and is per- forming a grave disservice to squinting
Arthralgia Associated With -Adrenergic Blockade
Authors: J. M. Sills, L. Bosco
Journal: JAMA (1986)

<h3>To the Editor.—</h3> Arthropathy induced by β-adrenergic blockage is not a commonly associated finding, although arthralgia does appear in the product labeling for the β-blockers timolol maleate (Blocadren) and pindolol (Visken). A recent report has called attention to a number of cases of arthropathy associated with various β-blockers, the most frequently implicated being metoprolol.<sup>1</sup> The Division of Drug and BiologicalProduct Experience at the Food and Drug Administration has received reports of five cases of metoprolol-associated arthralgia through its Spontaneous Reporting System. However, in the age range susceptible to arthritis, most had a negative arthritis and collagen vascular disease workup (Table). The most commonly affected joint was the knee; however, pain and swelling were usually associated with multiple joints. Accompanying symptoms ranged from none to fever and chills. Symptoms resolved upon discontinuation of metoprolol treatment in all cases, usually within two to three days. Two patients experienced a recurrence
THE REMOVAL OF FOREIGN BODIES FROM THE AIR AND FOOD PASSAGES
Authors: D. R. Paterson
Journal: BMJ (1908)

igoS 4. Headache follows both; that of migraine being more severe.5. The aura of migraine seldom affects a leg or. the trank.6. Somnolence may occur in both.As Gowers says, " it is curlous that the most frequent ralation between epilepsy and migraine is as a source of error between the two."Of course, one always has to remember that they are both comparatively common complaints, and there will be a natural overlapping, apart from any affinity.The antecedents of migraine are migraine or gout, those of epilepsy being epilepsy or insanity.In migraine there is no deterioration of mind.
Descartes' Error: Emotion, Reason and the Human Brain
Authors: S. Spence
Journal: BMJ (1995)

Antonio R Damasio Picador, pounds sterling16.99, pp 312 ISBN 0 330 33927 3

Documentary makers find the brain sexy at present; surf the television channels and the workings of the psyche are hard to avoid: violence, paraphilias, psychopathy, all are explained.

Brain books are similarly popular. They come in three varieties. There is the “you're only” school: you're only a cluster of neurons (Francis Crick), processes (Daniel Dennett), microtubules (Sir Roger Penrose) and so on in a reductionist vein. Humans are considered from a pathological/laboratory perspective. Computer metaphors abound (your mind is your software!) and there are boxes and arrows in profusion. Such books …
Urticarial vasculitis induced by centrally acting appetite suppressants
Authors: E. Papadavid, R.C. Yu, A. Tay, A.C. Chu
Journal: British Journal of Dermatology (1996)

Journal Article Urticarial vasculitis induced by centrally acting appetite suppressants Get access E. Papadavid, E. Papadavid Unit of Dermatology Search for other works by this author on: Oxford Academic Google Scholar R.C. Yu, R.C. Yu Unit of Dermatology Search for other works by this author on: Oxford Academic Google Scholar A. Tay, A. Tay Department of Histopathology, Hammersmith Hospital, RPMS, London W12 0NN, U.K.Unit of Dermatology Search for other works by this author on: Oxford Academic Google Scholar A.C. Chu A.C. Chu Unit of Dermatology Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 134, Issue 5, 1 May 1996, Pages 990–991, https://doi.org/10.1111/j.1365-2133.1996.tb06351.x Published: 01 May 1996
GSK chief defends profits made on back of swine flu crisis
Authors: H. Mooney
Journal: BMJ (2010)

Andrew Witty, chief executive of global drug company GlaxoSmithKline, has denied accusations that the company profiteered during the swine flu crisis. Last year the company made a pre-tax profit of more than $13bn (£8.5bn; €9.8).

In an interview on the BBC’s World Have Your Say programme on 26 April Mr Witty denied that the company had “charged the whole world” for a vaccine that may not have been necessary.

“We have spent $2.5bn over the last seven years preparing for this situation, I think we charged a very …
AIDS Enteropathy: Occult Enteric Infections and Duodenal Mucosal Alterations in Chronic Diarrhea
Authors: Joel K. Greenson, Peter C. Belitsos, John H. Yardley, John G. Bartlett
Journal: Annals of Internal Medicine (1991)

Objective: To investigate occult enteric infections and morphologic changes in the small intestine in patients with advanced human immunodeficiency virus (HIV) infection and chronic diarrhea of undefined cause. Design: Case-control study. Setting: Referral-based clinic and hospital in tertiary care center. Patients: Twenty-two patients with advanced HIV infection (19 with the acquired immunodeficiency symdrome [AIDS], 3 with AIDS-related complex) with chronic diarrhea, selected because of previously negative stool evaluations for bacterial or parasitic pathogens, were compared with 13 patients with advanced HIV infection (9 with AIDS, 4 with AIDS-related complex) without diarrhea by analysis of endoscopic biopsies using light and electron microscopy, viral culture, and morphometric studies. Both groups were convenience samples and had at least 7 months follow-up. Measurements and Main Results: Eleven of twenty-two patients with HIV infection and chronic diarrhea but only 1 of 13 patients without diarrhea showed occult enteric pathogens (that is, undetected by routine studies) after extensive evaluation of duodenal and colorectal biopsies. Mycobacterium avium-intracellulare and microsporidia were the most common occult agents in study patients with diarrhea (5 each). Patients with diarrhea and occult enteric infections had greater weight loss (mean, 14.3 kg compared with 6.2 kg; P < 0.05) and shorter survival (1 of 11 compared with 8 of 11 still alive; P < 0.004) than those with diarrhea but no identified pathogens (defined as "AIDS enteropathy"). Duodenal morphometry showed decreased villus-to-crypt ratios because of villus atrophy and crypt elongation in HIV-infected patients both with and without diarrhea compared with normal controls (P < 0.001 for each). All three groups showed comparable frequencies of epithelial mitoses. Conclusions: Further endoscopic biopsy evaluation of patients with AIDS who had unexplained chronic diarrhea showed an occult infectious cause in half of the cases. However, altered villus and crypt architecture in advanced HIV infection was independent of the presence of diarrhea or enteric infection and therefore did not correlate with AIDS enteropathy. Subnormal epithelial proliferation in response to injury could be a factor, but the underlying cause of the architectural changes remains obscure. We suggest that T-cell dysfunction may play a role.