GB Virus C and Hepatitis C Virus Infection in Patients with Mixed Cryoglobulinemia
Authors: Giulia Morsica, Giovanni Sitia, Dario Roccatello
Journal: Annals of Internal Medicine (2000)

Letters5 September 2000GB Virus C and Hepatitis C Virus Infection in Patients with Mixed CryoglobulinemiaGiulia Morsica, MD, Giovanni Sitia, MD, and Dario Roccatello, MDGiulia Morsica, MDSan Raffaele Scientific Institute; 20127 Milan, Italy (Morsica, Sitia)University of Turin; 10152 Turin, Italy (Roccatello)Search for more papers by this author, Giovanni Sitia, MDSan Raffaele Scientific Institute; 20127 Milan, Italy (Morsica, Sitia)University of Turin; 10152 Turin, Italy (Roccatello)Search for more papers by this author, and Dario Roccatello, MDSan Raffaele Scientific Institute; 20127 Milan, Italy (Morsica, Sitia)University of Turin; 10152 Turin, Italy (Roccatello)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-5-200009050-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Recently, hepatitis C virus (HCV) has been indicated as the major causative agent of mixed cryoglobulinemia (1). GB virus C (GBV-C) is a member of the Flaviviridae family (2) and shares routes of transmission and some sequence homologic characteristics with HCV. We searched for GBV-C and HCV genomic sequences in serum and cryoprecipitate samples of 34 patients with symptomatic mixed cryoglobulinemia not related to autoimmune, connective tissue, or lymphoproliferative diseases (16 patients with type II and 18 with type III cryoglobulins). In 30 of 34 patients, anti-HCV antibodies were detected by third-generation enzyme-linked immunosorbent assay. Twenty-six patients ...References1. Agnello V, Chung RT, Kaplan LM. A role for hepatitis C virus infection in type II cryoglobulinemia. N Engl J Med. 1992;327:1490-5. CrossrefMedlineGoogle Scholar2. Linnen J, Wages J, Zhang-Keck ZY, Fry KE, Krawczynski KZ, Alter H, et al . Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent. Science. 1996;271:505-8. CrossrefMedlineGoogle Scholar3. Misiani R, Mantero G, Bellavita P, Mori L, Vicari O, Marchesi D, et al . GB virus C infection in patients with type II mixed cryoglobulinemia. Ann Intern Med. 1997;127:891-4. LinkGoogle Scholar4. Liu F, Knight GB, Agnello V. Hepatitis C virus but not GB virus C/hepatitis G virus has a role in type II cryoglobulinemia. Arthritis Rheum. 1999;42:1898-901. CrossrefMedlineGoogle Scholar5. Crovatto M, Mazzaro C, Mishiro S, Santini G, Baracetti S, Zorat F, et al . GBV-C/HGV and HCV infection in mixed cryoglobulinaemia. Br J Haematol. 1999;106:510-4. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Giulia Morsica, MD; Giovanni Sitia, MD; Dario Roccatello, MDAffiliations: San Raffaele Scientific Institute; 20127 Milan, Italy (Morsica, Sitia)University of Turin; 10152 Turin, Italy (Roccatello) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRecognizing the new disorder “idiopathic hypocryoglobulinaemia” in patients with previously unidentified clinical conditionsCryoglobulinemic glomerulonephritis: clinical presentation and histological features, diagnostic pitfalls and controversies in the management. State of the art and the experience on a large monocentric cohort treated with B cell depletion therapyCryoglobulinemiasRelationship between cryoglobulinemia-associated nephritis and HCV infectionMulticenter Study on Hepatitis C Virus–Related Cryoglobulinemic Glomerulonephritis 5 September 2000Volume 133, Issue 5Page: 394-395KeywordsAntibodiesConnective tissueEnzyme linked immunosorbent assayGenomicsHepatitis C virusHepatitis G virusInfectious hepatitisMixed connective tissue diseasePathogenesisRNA ePublished: 5 September 2000 Issue Published: 5 September 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...