Lactic Acidosis and AIDS
Authors: Patrick Chariot
Journal: Annals of Internal Medicine (1993)

Letters15 August 1993Lactic Acidosis and AIDSPatrick Chariot and Marie-Laure Debreuil-LemairePatrick ChariotSearch for more papers by this author and Marie-Laure Debreuil-LemaireSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-4-199308150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Chattha and colleagues [1] suggested that the lactic acidosis was related to mitochondrial dysfunction induced by zidovudine therapy. No information was given about cumulative doses of zidovudine nor were attempts made to document zidovudine mitochondrial myopathy by clinical testing, evaluation of serum creatine kinase level, electromyogram, or muscle biopsy.We report a patient with zidovudine-associated myopathy who developed severe lactic acidosis. A 68-year-old man with AIDS was treated with zidovudine for 14 months (total dose, 200 g), after which myalgias and proximal weakness developed. Muscle biopsy specimens showed numerous, ragged red fibers, myofilamentous abnormalities, and cytochrome c ...References1. Chattha G, Arieff AI, Cummings C, Tierney LM Jr. Lactic acidosis complicating the acquired immunodeficiency syndrome. Ann Intern Med. 1993; 118:37-9. Google Scholar2. Chariot P, Gherardi R. Partial cytochrome c oxidase deficiency and cytoplasmic bodies in patients with zidovudine myopathy. Neuromuscul Disord. 1991; 1:357-63. Google Scholar3. Illa I, Nath A, Dalakas M. Immunocytochemical and virological characteristics of HIV-associated inflammatory myopathies: similarities with seronegative polymyositis. Ann Neurol. 1991; 29:474-81. Google Scholar4. Lewis W, Papoian T, Gonzalez B, Louie H, Kelly DP, Payne RM, et al. Mitochondrial, ultrastructural and molecular changes induced by zidovudine in rat hearts. Lab Invest. 1991; 65:228-36. Google Scholar5. Gopinath R, Hutcheon M, Cheemahadli S, Halperin M. Chronic lactic acidosis in a patient with acquired immunodeficiency syndrome and mitochondrial myopathy: biochemical studies. J Am Soc Nephrol. 1992; 3:1212-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNucleoside Reverse Transcriptase Inhibitors, Mitochondrial Dna and Aids TherapyLactic acidosis related to nucleoside therapy in HIV-infected patientsSevere Nucleoside-Associated Lactic Acidosis in Human Immunodeficiency Virus–Infected Patients: Report of 12 Cases and Review of the LiteratureThe Chemical Pathology of AIDSLactic acidosis and acquired immunodeficiency syndromeMitochondrial Dysfunction and Nucleoside Reverse Transcriptase Inhibitor Therapy 15 August 1993Volume 119, Issue 4Page: 343-345KeywordsAIDSCreatine kinaseImmunohistochemistryLactatesLactic acidosisMuscle biopsiesMusclesMyalgiaSepsisSkeletal muscles ePublished: 15 August 2000 Issue Published: 15 August 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...