tbuckley/cabot-search huggingface dataset:
Abstract 1512: The linamarase/linamarin/glucose oxidase cocktail cures human gliomas in rats
Authors: Marta L. Izquierdo, Jon Gil, Willie Girald
Journal: Cancer Research (2010)

Abstract Glioblastoma multiforme (GBM) is one of the dedliest forms of cancer, with an average survival time of approximately one year despite aggressive surgery, radiotherapy and chemotherapy. We will report a therapeutic procedure with potential clinical utility, by which the two main energy pathways of the tumor cells, oxidative phosphorylation and aerobic glycolysis, are simultaneously disrupted. First, the neoplastic cells must receive the plant linamarase gene (LI), which mediates the transformation of linamarin (LIN) into cyanide, glucose and acetone. Shortly after, we administer a systemic treatment with both linamarin and glucose oxidase (GOD) for 7 days. This creates a synergistic effect by which the neoplasm collapses in a few days. Autophagy is the cellular death mechanism involved in the eradication of the tumor. One hundred percent of the tumors disappear and neither relapse nor side effects are manifested. This therapeutic procedure also destroys the highly metastatic stem cell population from the human glioblastoma implants, thus preventing recurrence of the disease. This simple treatment is the first that can cure in a few days human brain tumors xenotransplanted into the brain of nude rats. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1512.
it is not evolution, but a better game would need a better agent
Authors: christian huyck, ian mitchell
Journal: Behavioral and Brain Sciences (2005)

steels &amp; belpaeme (s&amp;b) refer to the neural plausibility and evolutionary plausibility of their algorithms. although this is not central to their goal of effective artificial agents, their algorithms are not neurally or evolutionarily plausible. their communication games are interesting, and more complex games would lead to more effective agents. however, the algorithms could be improved either by using standard subsymbolic algorithms or by algorithms that are really neurally or evolutionarily plausible.
Chlorambucil for Childhood Nephrosis
Authors: Edmund J. Lewis
Journal: New England Journal of Medicine (1980)

The term minimal-change glomerulopathy applies to the renal histology noted in the majority of children with the idiopathic nephrotic syndrome. Almost no change in glomerular morphology is found, but there is a subtle ultrastructural alteration in the epithelial cells that is referred to as "foot-process fusion." The virtual absence of histopathologic abnormalities is in striking contrast to the functional breakdown in the selective-permeability barrier of the glomerular capillary wall. The glomerular albumin leak causes profound hypoalbuminemia and hypovolemia with consequent renal retention of salt and water. Little is known of the cause of this lesion, and therapeutic approaches to the . . .
Hepatitis C in HIV-Infected Intravenous Drug Users and Homosexual Men in Suburban New York City
Authors: Gary P. Wormser
Journal: JAMA (1991)

To the Editor.—  Abnormal liver function test results are common in patients infected with the human immunodeficiency virus (HIV), and, although they are likely to be multifactorial in origin, they are undoubtedly related to viral hepatitis in some of these patients. The recent discovery of a serological marker for the hepatitis C virus has greatly improved diagnostic accuracy for this form of hepatitis.1Hepatitis C virus infection may be an important cause of significant liver disease in certain HIV-infected patients and poses an additional concern for health care personnel with occupational exposure to blood. In European studies, hepatitis C coinfection rates in excess of 50% have been found for both HIV-infected hemophiliacs and intravenous drug users, with rates as high as 26% reported for HIV-infected homosexual men.2,3  Few data are available, however, on hepatitis C coinfection rates for HIV-infected patients in the United States. The results of hepatitis
Identification of high risk labours by labour nomogram.
Authors: J Studd, D R Clegg, R R Sanders, A O Hughes
Journal: BMJ (1975)

The labour stencil representing the expected cervimetric progress of normal labour was used in 741 consecutive spontaneous labours to identify high-risk labours which needed oxytocic stimulation. Uterine contractions were stimulated if progress extended two hours past the nomogram, which resulted in shorter labours, fewer instrumental deliveries and caesarean sections, and babies with higher Apgar scores than in those dysfunctional labours which were not stimulated. According to the protocol used 36% of primigravid and 13% of multigravid labours needed acceleration. The remaining patients did not need any oxytocic interference during the first stage. This selection of patients is important to prevent a major obstetric advance being abused and discredited at a time when the profession and public are questioning the safety of active labour.
Recent evidence of the involvement of lateral frontal cortex in primate cyclic ingestive movements
Authors: Barry J. Sessle
Journal: Behavioral and Brain Sciences (1998)

This commentary focusses on MacNeilage's arguments and evidence that the development of cerebral cortical controls over cyclic ingestive movements has provided substrates for the evolution of speech production. It outlines evidence from experimental approaches using cortical stimulation, inactivation, and single neuron recording in primates that lateral frontal cortical regions are indeed crucial for the generation and guidance of cyclic orofacial movements.
Effect of long-term treatment with cimetidine and antacids in Barrett's oesophagus.
Authors: I C Wesdorp, J Bartelsman, M E Schipper, G N Tytgat
Journal: Gut (1981)

The effect of a long-term treatment (one to two years) with cimetidine (1.6 g per day) and an antacid (Regla pH) was evaluated in nine patients with a Barrett9s oesophagus. The results showed that such long-term treatment had a beneficial effect on the symptoms and endoscopic signs of oesophagitis and on the healing of a Barrett9s ulcer, but did not result in a regression of the squamocolumnar junction back towards the cardia. No significant changes were observed in the histological epithelial types in the biopsies taken below the squamocolumnar junction. No clinical or biochemical side-effects or changes in biochemical parameters were noted during this study.
Cardiac Arrest in Schools
Authors: Katayoun Lotfi, Lindsay White, Tom Rea, Leonard Cobb, Michael Copass, Lihua Yin, Linda Becker, Mickey Eisenberg
Journal: Circulation (2007)

The purpose of the present study is to improve understanding of the epidemiology of cardiac arrest in the school setting, with a special focus on the role of school-based automated external defibrillators.The investigation was a retrospective study of emergency medical service-treated, nontraumatic, out-of-hospital cardiac arrests in Seattle and King County, Washington, that occurred in schools between 1990 and 2005. Cases were identified with cardiac arrest location data from emergency medical service cardiac arrest registries. Patient characteristics, cardiac arrest characteristics, and outcome information were abstracted from the registries and incident report forms. During the study period, 97 cardiac arrests occurred in schools, accounting for 0.4% of all treated cardiac arrests and 2.6% of public location cardiac arrests. Of the 97 cases, 12 cardiac arrests were among students, 33 among faculty and staff, and 45 among adults not employed by the school (7 adults with indeterminate school association). School-based cardiac arrest occurred on average in 1 of 111 schools annually, with a greater annual incidence among colleges (1 cardiac arrest per 8 colleges) than high schools (1 per 125 high schools) or lower-level schools (1 cardiac arrest per 200 preschools through middle schools). The estimated annual incidence of cardiac arrest was 0.18 per 100,000 person-years among students and 4.51 per 100,000 person-years for school faculty and staff.The present study characterizes school-setting cardiac arrest and provides a framework within which to consider preparation efforts and outcome expectations.
Remarks on RENAL FUNCTIONAL DISTURBANCE IN ACUTE AND SUBACUTE NEPHRITIS
Authors: J. S. Dunn
Journal: BMJ (1933)

been a considerable recession from the conception of Remarks oedema as the direct effect of the renal disability, both in oN acute aind in sul)acute nephritis.The reasons for this RENAL FUNCTIONAL DISTURBANCE IN departure differ to some extent in the two stages, and it ACUTE AND SUBACUTE NEPHRITIS * may be said as regards subacute nephritis that, while ACUTE AND SUBACUTE NEPHRITIS *various authorities agree that there are extrarenal causes, BY they disagree as to the nature of these causes, and their J.SHAW DUNN, M.D., MI.Sc.reasons are niot always compatible.This may be re-
Effect of Vitamin D Intake on Seasonal Variations in Parathyroid Hormone Secretion in Postmenopausal Women
Authors: Elizabeth A. Krall, Nadine Sahyoun, Saul Tannenbaum, Gerard E. Dallal, Bess Dawson-Hughes
Journal: New England Journal of Medicine (1989)

Vitamin D intake should be sufficient to maintain calcium absorption and prevent increased parathyroid secretion throughout the year. To determine the level of intake that achieved the latter in elderly women, we studied the interrelations among vitamin D intake, serum 25-hydroxyvitamin D (25(OH)D) levels, and parathyroid hormone concentrations in a cross-sectional study of 333 healthy, white, postmenopausal women with low median calcium (408 mg a day) and vitamin D (112 IU a day) intakes who lived in Massachusetts. The overall inverse relation between serum parathyroid hormone and 25(OH)D levels was found to be dependent on vitamin D intake. In women whose estimated intake of vitamin D was ≤220 IU a day, the mean (±SD) serum parathyroid hormone values were lowest in those studied between August and October (30±11 ng per liter; n = 72) and highest in those studied between March and May (37±16 ng per liter; n = 54); the respective serum 25(OH)D levels were 93±32 and 63±21 nmol per liter. At vitamin D intakes of more than 220 IU a day, the mean serum parathyroid hormone and 25(OH)D levels did not vary with the season. The correlation between vitamin D intake and serum 25(OH)D concentration, although significant in all women (r = 0.29; P<0.001), was highest in those studied between March and May (r = 0.65; P<0.001) and lowest in those studied between August and October (r = 0.13; P>0.10). The estimated serum 25(OH)D level associated with a vitamin D intake of 220 IU a day between March and May was 95 nmol per liter. Mean serum calcium values were similar at all times in both groups. We conclude that the dietary intake of more than 220 IU of vitamin D a day by postmenopausal women in Massachusetts may be sufficient to maintain constant serum 25(OH)D and parathyroid hormone concentrations throughout the year. Such an intake prevents a seasonal increase in parathyroid hormone secretion, with its possible deleterious skeletal effects. (N Engl J Med 1989; 321:1777–83.)
Assisted ventilation modes reduce the expression of lung inflammatory and fibrogenic mediators in a model of mild acute lung injury
Authors: Felipe Saddy, Gisele P. Oliveira, Cristiane S. N. B. Garcia, Liliane M. Nardelli, Andreia F. Rzezinski, Debora S. Ornellas, Marcelo M. Morales, Vera L. Capelozzi, Paolo Pelosi, Patricia R. M. Rocco
Journal: Intensive Care Medicine (2010)
An Address on Endemic Disease in British Guiana and on Certain Racial Susceptibilities
Authors: R. Grieve
Journal: BMJ (1890)

This belief in the contagious nature of leprosy still remains in many countries, and lepers are carefully isolated in Norway.But the greatest differences of opinion prevail on this question amongst medical men.In the Report of the Royal College of Physicians in 1860, the Commission state decidedly "that the weight and value of the evidence they furnish is greatly in favour of the non-contagious- ness of leprosy" (p.75; and again: " The all but unanimous con- nction of the most experienced observers in different parts of the world is quite opposed to the belief that leprosy is contagious or communicable by proximity or contact with the disease."Just as we shall see presently in the case of phthisis, they quote the experience of hospitals and the immunity of the attendants in leper asylums.In the discussion on this question at the International Congress at Copenhagen, in 1884, the two chief speakers-Dr.Zambuco, of Constantinople, and Dr. Hansen, of Christiania-took entirely op- posite views; the former maintaining that leprosy is not con- tagious, but is hereditary, and the latter that it is contagious, and not hereditary.Dr. Danielssen, the father of research on the subject, also takes the non-contagious view, and says: " According to my observation, heredity is sufficiently proved, whilst I have not found one single well-proved case of infection."VII.With regard to heredity, Dr. Hansen states that of 160 Norwegian lepers who had settled in the States of Wisconsin, Min- nesota, and Dacota, none of the offspring, in some cases as far as the great, great grandchildren, have shown signs of the disease.He points out that there could have been no question of heredity in the case of the great outbreak of the disease in Hawaii.A recent writer on the subject, Dr. Albert Neisser, also considers that leprosy is not an hereditary disease, though he acknowledges that the susceptibility of the individual appears to be of more importance than in any other bacterial disease.It is not surprising that with all these points of similarity, the question should be asked, as it is by Danielssen, whether " Leprosy is not itself a tuberculous disease?"The circumstance that the
Abstract B02: Matrix stiffness regulates local metabolism of breast carcinoma cells
Authors: Brian Burkel, Suzanne Ponik, Brett Morris, Kevin Eliceiri, Patricia Keely
Journal: Cancer Research (2015)

Abstract Dense breast tissue is one of the single largest risk factors for the development of breast cancer, and one of the primary proteins responsible for increased breast density is the core extracellular matrix (ECM) component, collagen. Similar to other ECM proteins, collagen plays a structural role underlying tissue organization and increased collagen deposition correlates to a stiffer ECM and cellular microenvironment. Interestingly, changes to the stiffness of the ECM or microenvironment have profound and poorly-understood effects on cell migration, cell proliferation, and cancer progression. Consistent with an expanding role of ECM stiffness in cell signaling, we report that increased matrix stiffness also affects cellular metabolism and respiration. Using specific pharmacological inhibitors and quantitative imaging modalities like fluorescence lifetime microscopy, we are able to show that changes in collagen stiffness can cause a metabolic shift towards a more glycolytic, Warburg-like equilibrium in breast carcinoma cells. Matrix stiffness regulates the expression of several metabolic enzymes, including PDHK-1, which is poised to regulate this shift. Note: This abstract was not presented at the conference. Citation Format: Brian Burkel, Suzanne Ponik, Brett Morris, Kevin Eliceiri, Patricia Keely. Matrix stiffness regulates local metabolism of breast carcinoma cells. [abstract]. In: Abstracts: AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment; 2014 Feb 26-Mar 1; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(1 Suppl):Abstract nr B02. doi:10.1158/1538-7445.CHTME14-B02
THE TOXICITY OF HUMAN SERUM FOR THE GUINEA PIG
Authors: Susan Griffith Ramsdell, I. Davidsohn
Journal: The Journal of Experimental Medicine (1929)

From the foregoing study there are indications: 1. Of toxicity in all fresh human serum for the guinea pig; this toxicity tends to disappear after 48 hours after bleeding, and its manifestations are strikingly similar to those of the heterophilic antibody in immune rabbit serum. 2. Of an increased toxicity in the serum of antisera-treated human cases; this is usually coexistant with the production of other antibodies; it tends likewise to disappear in time after treatment; differential absorption experiments indicate that its character is heterophilic, and its manifestations differ from those of anaphylaxis in that certain circulatory effects—hemorrhage and increased edema in the lungs and distension of the right heart—are added to the usual findings in true anaphylactic deaths.
Locating Parathyroid Adenomas via Virtual Neck Exploration
Authors: Peter Angelos
Journal: JAMA Surgery (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Guideline for End-of-Life Care Released
Authors: Bridget M. Kuehn
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy
Authors: Ursula Grohmann, Claudia Volpi, Francesca Fallarino, Silvia Bozza, Roberta Bianchi, Carmine Vacca, Ciriana Orabona, Maria L Belladonna, Emira Ayroldi, Giuseppe Nocentini, Louis Boon, Francesco Bistoni, Maria C Fioretti, Luigina Romani, Carlo Riccardi, Paolo Puccetti
Journal: Nature Medicine (2007)
THE DESTRUCTION OF CONJUNCTIVAL GROWTHS BY ANIMAL FERMENTS.
Authors: T. O. SUMMERS
Journal: JAMA (1894)

Having been for some time past engaged in the work of experimentation upon the therapeutic uses of the animal ferments in surgical diseases, I desire among many remarkable instances of the powerful digestive action of these agents upon the neoplastic structure to call the attention of the profession to a case of cauliflower excrescences upon the conjunctiva of the lower lid, which are well known to the ophthalmologist and have hitherto been considered amenable only to surgical treatment—complete excision. In the case referred to, the lower lid was covered with a number of these growths, columnar in structure and of rapid growth. The removal of them by escharotics was not for a moment to be considered on account of the danger of injury to the normal structures in which they were imbedded. After thoroughly cleansing the surface and applying cocain to relieve the pain I covered the surface thoroughly with
REGULATION OF THE PRACTICE OF MEDICINE.
Authors: JUDGE JOHN I. DILLE
Journal: JAMA (1900)

The power and the duty of the states to regulate the practice of medicine have been fully established. It is the inalienable right and imperative duty of the government, by legislation, to promote the health, morals, education and good order of the people. This right, vested in the people in their sovereign capacity, has been likened to the individual right of self-defense, the exercise of which is a part of the law of self-preservation. The police is a plenary power, and may be exercised by the state to regulate or prohibit things inconsistent with the public welfare. No other function of government has been so frequently appealed to, nor so successfully exercised, and none other is of greater importance to the people, individually and collectively. We look to this power for the suppression and punishment of crime, the preservation of public peace, the regulation of dangerous employments, the sale and
Renal Scintigraphy of an Infarction in an En Bloc Transplantation of a Horseshoe Kidney
Authors: FERNANDO CESANI, VIKEN DOUZDJIAN, SEHAM ALI, JAVIER VILLANUEVA-MEYER
Journal: Clinical Nuclear Medicine (1995)

A 30-year-old woman with end stage renal disease received a cadaveric horseshoe kidney transplant. The horseshoe kidney embryologically represents the fusion of the lower poles of the kidneys in 95% of occasions. Another characteristic is the abnormal blood supply thought to be persistent from the embryonic period. Because each renal artery supplies its own area, there is no collateral circulation between the areas—an artery ligated by accident will always cause an infarction. This often happens in the fusion bridge, which receives its separate blood vessels from the distal aorta, or even the lilac artery.