tbuckley/cabot-search huggingface dataset:
Milk-of-Calcium Renal Stone in Primary Hyperparathyroidism
Authors: GEORGE S. HARELL
Journal: Annals of Internal Medicine (1969)

A woman with a roentgenographic opacity in the right kidney shown to be milk-of-calcium renal stone was diagnosed as having primary hyperparathyroidism, confirmed by surgical removal of a chief-cell adenoma. Milk-of-calcium renal stone is a suspension of calcium salts layered at the bottom of a renal calyceal diverticulum or a cyst. The pathognomonic sign distinguishing it from a true renal calculus is the fluid level seen on the upright or decubitus films. Awareness of this rare entity may spare the patient nephrolithotomy since percutaneous aspiration may be sufficient therapy. The cause of renal milk-of-calcium is unknown. No previous reports have noted an association between it and primary hyperparathyroidism.
Serial 67Ga-Citrate Imaging During Treatment of Acute Osteomyelitis in Childhood
Authors: EMANUEL KOLYVAS, LEONARD ROSENTHALL, GERALD A. AHRONHEIM, ROBERT LISBONA, MELVIN I. MARKS
Journal: Clinical Nuclear Medicine (1978)

To test the hypothesis that abnormalities on 67Gacitrate scans parallel the clinical course of acute osteomyelitis and revert to normal with successful antibiotic therapy, serial scans were performed in ten children. Scans improved markedly within the first two to four weeks of treatment, but abnormalities persisted at six or more weeks in over 50% of the cases, despite complete clinical resolutions of disease.
Diffuse Small-Bowel Myelomatosis
Authors: Rebecca Weintraub, Sharmila Pramanik, Lee Levitt
Journal: New England Journal of Medicine (2004)

To the Editor: Extramedullary plasmacytomas are an unusual manifestation of multiple myeloma. Gastrointestinal plasmacytomas occur as discrete masses, usually involving either the stomach or colon, and can be mistaken for lymphoma.1–3 We report myeloma manifested as diffuse small-bowel myelomatosis. A 74-year-old man presented with a one-year history of diffuse abdominal pain, diarrhea, and weight loss (16 kg [35 lb]). He did not have bone pain. Physical examination revealed no abnormalities except for cachexia; mild, diffuse abdominal distention without tenderness or a palpable mass; and stools that were positive for occult blood on guaiac testing. His blood count was normal . . .
Molecular Epidemiology of Cytomegalovirus Infections Associated with Bone Marrow Transplantation
Authors: Drew J. Winston, Eng-Shang Huang, Marjorie J. Miller, Cheng-Hsein Lin, Winston G. Ho, Robert Peter Gale, Richard E. Champlin
Journal: Annals of Internal Medicine (1985)

Restriction endonuclease analysis of purified viral DNA was used to study the molecular epidemiologic characteristics of cytomegalovirus infection in 18 patients having bone marrow transplantation. Four patients who had had asymptomatic excretion of cytomegalovirus in urine before transplantation subsequently developed a cytomegalovirus infection after transplantation (pneumonia in 2 patients, fever and viremia in 1 patient, and asymptomatic viruria in 1 patient). In each patient, the infection that developed after transplantation was caused by a cytomegalovirus strain genetically identical to the isolate detected in urine before transplantation. Cytomegalovirus isolates from different sites (buffy coat, lung, and urine) of the same patient were also identical, but cytomegalovirus isolates from different patients were never identical. Our results suggest that some cytomegalovirus infections after bone marrow transplantation may be caused by strains present before transplantation. The great structural and genetic variability of cytomegalovirus isolates must be considered in the development of effective diagnostic and immunoprophylactic measures for infection after marrow transplantation.
Representation of South Asian people in randomised trials: Ethnic origin need not be a barrier to participation
Authors: H. Cooper
Journal: BMJ (2003)

EDITOR—Mason et al highlight the under-representation of South Asian people in some randomised clinical trials.1 This issue can be addressed by working in partnership with the local primary care trust. In the Heart of Birmingham teaching primary care trust, 58.5% of the population is from ethnic minority groups, compared with a national average …
An open study of a lotion formulation to improve tolerance of tacrolimus in facial atopic dermatitis
Authors: H. Sugiura, M. Uehara, N. Hoshino, A. Yamaji
Journal: British Journal of Dermatology (2001)

Journal Article An open study of a lotion formulation to improve tolerance of tacrolimus in facial atopic dermatitis Get access H. Sugiura, H. Sugiura Department of Dermatology and Hospital Pharmacy, Shiga University of Medical Science, Seta Tsukinowa‐cho, 520‐2192 Otsu, Japan H.Sugiura. E‐mail: sugiurah@belle.shiga‐med.ac.jp Search for other works by this author on: Oxford Academic Google Scholar M. Uehara, M. Uehara Department of Dermatology and Hospital Pharmacy, Shiga University of Medical Science, Seta Tsukinowa‐cho, 520‐2192 Otsu, Japan Search for other works by this author on: Oxford Academic Google Scholar N. Hoshino, N. Hoshino Department of Dermatology and Hospital Pharmacy, Shiga University of Medical Science, Seta Tsukinowa‐cho, 520‐2192 Otsu, Japan Search for other works by this author on: Oxford Academic Google Scholar A. Yamaji A. Yamaji Department of Dermatology and Hospital Pharmacy, Shiga University of Medical Science, Seta Tsukinowa‐cho, 520‐2192 Otsu, Japan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 5, 1 November 2001, Pages 795–798, https://doi.org/10.1046/j.1365-2133.2001.04467.x Published: 01 November 2001
Bush administration should be investigated for torture of prisoners, says human rights group
Authors: J. H. Tanne
Journal: BMJ (2010)

A human rights group has called on Barack Obama to start immediate criminal investigation of alleged experimentation and research on terrorist suspects detained after the attacks in the United States on 11 September 2001.

Physicians for Human Rights, a US organisation of health professionals, alleges that doctors and other health professionals working for the Central Intelligence Agency monitored and refined “enhanced” interrogation techniques to make sure they stayed within the boundaries drawn up by the Bush administration.

It charges that the administration “apparently conducted illegal and unethical human experimentation and research on detainees in CIA custody.”

Seven other organisations signed the complaint, including Amnesty International USA, the Center for Constitutional Rights, and the Center for Victims of Torture.

The change in status from detainees to research subjects means that the doctors’ role “could violate accepted standards of medical ethics, as well as domestic and international law,” says the group’s report. “These practices …
A novel double-coating carrier produced by solid-in-oil and solid-in-water nanodispersion technology for delivery of genes and proteins into cells
Authors: Yoshiro Tahara, Takeshi Kaneko, Riki Toita, Chiharu Yoshiyama, Takuya Kitaoka, Takuro Niidome, Yoshiki Katayama, Noriho Kamiya, Masahiro Goto
Journal: Journal of Controlled Release (2012)
Differences in allergic sensitization by self-reported race and genetic ancestry
Authors: James J. Yang, Esteban G. Burchard, Shweta Choudhry, Christine C. Johnson, Dennis R. Ownby, David Favro, Justin Chen, Matthew Akana, Connie Ha, Pui-Yan Kwok, Richard Krajenta, Suzanne L. Havstad, Christine L. Joseph, Max A. Seibold, Mark D. Shriver, L. Keoki Williams
Journal: Journal of Allergy and Clinical Immunology (2008)
Health-related fitness and physical activity in patients with nonalcoholic fatty liver disease
Authors: Joanne B. Krasnoff, Patricia L. Painter, Janet P. Wallace, Nathan M. Bass, Raphael B. Merriman
Journal: Hepatology (2008)

Nonalcoholic fatty liver disease (NAFLD) has been referred to as the hepatic manifestation of the metabolic syndrome. There is a lower prevalence of metabolic syndrome in individuals with higher health-related fitness (HRF) and physical activity (PA) participation. The relationship between NAFLD severity and HRF or PA is unknown. Our aim was to compare measures of HRF and PA in patients with a histological spectrum of NAFLD severity. Thirty-seven patients with liver biopsy-confirmed NAFLD (18 women/19 men; age = 45.9 +/- 12.7 years) completed assessment of cardiorespiratory fitness (CRF, VO(2peak)), muscle strength (quadriceps peak torque), body composition (%fat), and PA (current and historical questionnaire). Liver histology was used to classify severity by steatosis (mild, moderate, severe), fibrosis stage (stage 1 versus stage 2/3), necroinflammatory activity (NAFLD Activity Score; <or=4 NAS1 versus >or=5 NAS2) and diagnosis of NASH by Brunt criteria (NASH versus NotNASH). Analysis of variance and independent t tests were used to determine the differences among groups. Fewer than 20% of patients met recommended guidelines for PA, and 97.3% were classified at increased risk of morbidity and mortality by %fat. No differences were detected in VO(2peak) (x = 26.8 +/- 7.4 mL/g/min) or %fat (x = 38.6 +/- 8.2%) among the steatosis or fibrosis groups. Peak VO(2) was significantly higher in NAS1 versus NAS2 (30.4 +/- 8.2 versus 24.4 +/- 5.7 mL/kg/min, P = 0.013) and NotNASH versus NASH (34.0 +/- 9.5 versus 25.1 +/- 5.7 mL/kg/min, P = 0.048).Patients with NAFLD of differing histological severity have suboptimal HRF. Lifestyle interventions to improve HRF and PA may be beneficial in reducing the associated risk factors and preventing progression of NAFLD.
Common Malignancies With Uncommon Sites of Presentation
Authors: C.S. Chim, F. Loong, T. Yau, G.C. Ooi, R. Liang
Journal: Journal of Clinical Oncology (2003)

Article Tools DIAGNOSIS IN ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.03.167 Journal of Clinical Oncology - published online before print November 1, 2016 PMID: 14645437 Common Malignancies With Uncommon Sites of Presentation CASE 2. MANTLE-CELL LYMPHOMA OF THE PROSTATE GLAND C.S. ChimxC.S. ChimSearch for articles by this author , F. LoongxF. LoongSearch for articles by this author , T. YauxT. YauSearch for articles by this author , G.C. OoixG.C. OoiSearch for articles by this author , R. LiangxR. LiangSearch for articles by this author Show More University Departments of Medicine, Pathology, and Radiology, Queen Mary Hospital, University of Hong Kong, Hong Kong https://doi.org/10.1200/JCO.2003.03.167 First Page Full Text PDF Figures and Tables © 2003 by American Society of Clinical Oncology
Incidental Detection of Papillary Carcinoma of the Thyroid by Tc-99m (V) DMSA Tumor Scintigraphy
Authors: HISATAKA KOBAYASHI, YOSHIHIKO KOTOURA, TADAO TSUBOYAMA, MARIKO HOSONO, HARUMI SAKAHARA, JUNJI KONISHI
Journal: Clinical Nuclear Medicine (1995)

A 47-year-old woman with a previous history of multiple schwannomas in the extremities, underwent a follow-up whole body Tc-99m (V) DMSA scan. Unexpected intense radiotracer activity was seen in her right neck. Ultrasonography revealed a solid tumor with fine calcification In the right lobe of the thyroid gland. Subsequent surgical removal of the gland showed a papillary adenocarclnoma of the thyroid.
Relationships Between Homocysteine, Factor VIIa, and Thrombin Generation in Acute Coronary Syndromes
Authors: Mohamed K. Al-Obaidi, Helen Philippou, Peter J. Stubbs, Antonella Adami, Rajiv Amersey, Mark M. Noble, David A. Lane
Journal: Circulation (2000)

Background —It has been suggested by clinical, epidemiological, and experimental in vitro studies that homocysteine potentiates thrombin generation. This prothrombotic effect however has not previously been demonstrated in patients presenting with acute coronary syndromes (ACS). Methods and Results —Patients with ACS (n =117) presenting with confirmed acute myocardial infarction (MI) (n =57) or unstable angina pectoris (UAP) (n =60) were consecutively recruited together with patients (n =18) in whom the presenting chest pain was not of cardiac origin (NCP), included as controls. Plasma samples were collected on admission and before clinical intervention. Homocysteine was assayed by high performance liquid chromatography, and both Factor VIIa and prothrombin fragment F1+2 were analyzed by ELISA. There were significant elevations in F1+2 in MI ( P &lt;0.001) and UAP ( P =0.003), and modest elevations in Factor VIIa in UAP ( P &lt;0.05) compared with NCP but no differences in homocysteine levels among those groups. On dividing patients with ACS into quartiles of homocysteine, there was a stepwise increase in F1+2 ( P &lt;0.0001) and of Factor VIIa ( P &lt;0.05). There were significant correlations in ACS between homocysteine and F1+2 ( r =0.46, P &lt;0.0001), homocysteine and Factor VIIa ( r =0.24, P &lt;0.01), and F1+2 and Factor VIIa ( r =0.41, P &lt;0.0001). There was no correlation between homocysteine and either F1+2 ( r =−0.15, P =0.57) or Factor VIIa ( r =0.22, P =0.37) in the NCP patients. Conclusions —Elevated plasma homocysteine is associated with and may cause elevated Factor VIIa and thrombin generation in patients presenting with ACS. These findings suggest an explanation for the prothrombotic effect of homocysteine in ACS.
Immigrants could be charged 500 a year to use NHS
Authors: N. Hawkes
Journal: BMJ (2013)

People moving to the United Kingdom for up to five years should pay a levy on entry to the country if they wish to make use of NHS services, a consultation from the government has suggested.1 

Those who have not paid would not be permitted to access routine care, including primary care by GPs, except in case of emergencies, when they would be charged. The levy may be waived for people with comprehensive medical insurance that could be used to pay for NHS treatment.

People who have not paid the levy—at least £200 (€235; $305) a year and possibly £500 a …
A Look Ahead at the Future of Diabetes Prevention and Treatment
Authors: David E. Arterburn, Patrick J. O’Connor
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impaired Suppression of Sympathetic Activity during Fasting in the Gold Thioglucose-treated Mouse
Authors: James B. Young, Lewis Landsberg
Journal: Journal of Clinical Investigation (1980)

Sympathetic activity in rats and mice is diminished by fasting and increased by sucrose feeding. The central neural mechanisms coordinating changes in the functional state of sympathetic nerves with changes in dietary intake are unknown, but a role for neurons in the ventromedial hypothalamus (VMH) is suggested by the existence of sympathetic connections within the VMH and the importance of this region in the regulation of feeding behavior. To investigate the potential role of the VMH in dietary regulation of sympathetic activity [3H]norepinephrine turnover was measured in the hearts of fasted and sucrose-fed mice after treatment with gold thioglucose (AuTG). In control mice, norepinephrine (NE) turnover was 1.60±0.92 ng NE/heart per h (95% confidence limits) after 1 d of fasting and 4.58±0.98 after 3 d of sucrose feeding, although, in AuTG-treated mice, cardiac NE turnover in fasting was 5.45±1.56 and with sucrose feeding, 5.44±0.76. Experiments with ganglionic blockade indicate that the absence of dietary effect on NE turnover in AuTG-treated mice reflects a corresponding lack of change in central sympathetic outflow. AuTG administration, therefore, disrupts dietary regulation of sympathetic activity by abolishing the suppression of sympathetic activity that occurs with fasting. This effect of AuTG is unrelated to duration of fasting (up to 3 d) and is specific for AuTG because neither treatment with another gold thio compound (gold thiomalate) nor the presence of genetic obesity (ob/ob) prevented fasting suppression of sympathetic activity. Moreover, AuTG treatment did not impair sympathetic activation by cold exposure (4°C) nor adrenal medullary stimulation by 2-deoxy-d-glucose. Thus, AuTG treatment selectively impairs dietary regulation of sympathetic activity, possibly by destruction of neurons in the VMH.
Principles and Practice of Emergency Medicine
Authors: Richard O. Cummins
Journal: JAMA (1987)

When the first edition of Schwartz'<i>Principles and Practice of Emergency Medicine</i>appeared nine years ago, it was the only available textbook on emergency medicine. Editor George R. Schwartz appeared to assume that emergency medicine was little more than the emergency components of sub-specialty skills. In 1983 the CV Mosby Company published the first edition of Rosen's<i>Emergency Medicine: Concepts and Clinical Practice</i>. Rosen's book was unquestionably the superior emergency medicine textbook. The contributors selected by Dr Rosen were physicians who practiced emergency medicine, and the chapters addressed topics from their perspective. Each chapter taught emergency physicians what they needed to know about pre-hospital care, what they needed to do in the emergency department, when to refer, when to consult, and when to admit. In contrast, the first edition of Schwartz' textbook read more like advice from subspecialists who arrived in the emergency department to assume care of the patient.
Depressed-type colon cancer in a patient with diverticulosis
Authors: N. Kobayashi, K. Hirabayashi, T. Matsui, Y. Hirahara, H. Kurihara, S. Igarashi, T. Ishikawa, R. Sekiguchi
Journal: Endoscopy (2008)

A 63-year-old man was referred to our hospital with a history of hematochezia. He had no previous history of abdominal complaints or of abdominal surgery. Physical examination and laboratory parameters showed no abnormalities. Colonoscopy revealed diverticulosis in the sigmoid colon, and a 2-cm-diameter, hard mass within multiple diverticula. The mass was surrounded by normal mucosa, mimicking a submucosal tumor, and an apparently depressed area was identified at the top of the lesion ([Fig. 1]). Because chromoendoscopy using indigo carmine dye clearly showed the margin of the depressed area, the lesion was suspected to be a depressed-type neoplasm, and magnifying colonoscopy with crystal-violet staining showed type IIIL and type IIIs Kudo pit patterns ([Fig. 2]), mainly corresponding to an intramucosal neoplasm; a biopsy sample from the depressed area showed features characteristic of adenoma. The lesion was finally diagnosed as a depressed-type intramucosal neoplasm arising from the diverticulum. Although these lesions are usually treated endoscopically, the coexistence of diverticulosis was thought to pose a high risk of perforation. A sigmoidectomy was therefore performed, and histopathological evaluation of the resected specimen revealed an intramucosal depressed-type adenocarcinoma, 18 mm × 15 mm in size, accompanied by numerous diverticula ([Fig. 3]). No evidence of lymph node metastasis was found, and the patient recovered uneventfully.
Questionable Relation of Aryl Hydrocarbon Hydroxylase to Lung-Cancer Risk
Authors: Beverly Paigen, Hira L. Gurtoo, Jun Minowada, Lorne Houten, Ronald Vincent, Kenneth Paigen, Natalie Bejba Parker, Elizabeth Ward, Nancy Thompson Hayner
Journal: New England Journal of Medicine (1977)

To test whether the genetically determined trait, aryl hydrocarbon hydroxylase inducibility, affects susceptibility to lung cancer, we measured this trait in cultured lymphocytes from a normal population, patients with lung cancer and progeny of such patients. We found very low aryl hydrocarbon hydroxylase activity (19 per cent of normal) in about half the patients with lung cancer. Only part of this activity can be accounted for by reduced cell growth and by reduced protein synthesis. In an indirect assessment of inducibility, both 57 progeny and 57 matched controls had a mean inducibility of 2.95 and a similar distribution into low, intermediate and high groups (chi-square = 0.3, P = 0.9). No differences in basal or induced activity were observed. Thus, if patients with lung cancer possess altered aryl hydrocarbon hydroxylase inducibility or activity these characteristics are not transmitted to their progeny. (N Engl J Med 297:346–350, 1977)
Smoking bans in public places may reduce use of cannabis in Europe
Authors: R. Watson
Journal: BMJ (2008)

Although drug misuse remains at historically high levels, it is entering a more stable phase, the latest annual report from the European Monitoring Centre for Drugs and Drug Addiction reports.

Wolfgang Gotz, the centre’s director, notes, “Overall, for most forms of consumption, we are not seeing major increases, and in some areas trends appear to be downwards. Indicators for amphetamines and ecstasy use, for example, suggest an overall steady or declining situation.”

Cannabis remains the most widely used drug, with 71 million people in Europe between the ages of 15 and 64 (equivalent to just over 20% of …
A British View of an American Hospital
Authors: J. F. Stokes
Journal: New England Journal of Medicine (1959)

"'Let's Fight till Six and Then Have Dinner,' Said Tweedledum"WHEN, after the lapse of a suitable time for evaporation and crystallization, I put to paper a few stray thoughts concerning my two short and most enjoyable weeks as visiting physician to the Massachusetts General Hospital in May, 1958, I did not expect to be asked to expand them into a more coherent form for publication. I am not the first physician to enjoy such hospitality, and it seems unlikely that my reactions have not already been experienced by others and possible that they would be modified by longer and . . .
RELATION OF RAILWAY COMPANIES TO STATE BOARDS OF HEALTH.
Authors: G. P. CONN
Journal: JAMA (1897)

In the last twenty years it has become a well-settled fact that State boards of health are primarily intended to take cognizance of the interests of health and life among the people of the State; and while it may be true that the work of a State board is to a considerable extent educational in its character, yet its scope is practically unlimited. Its observations and duties should not only pertain to the physical welfare of every citizen of a State, but business interests should receive due attention and the commercial relation of State, federal and international prosperity should never be ignored nor forgotten. Therefore, a bureau of health becomes an integral part of the executive department of a State, around which every citizen has the "inalienable right to life, liberty and the pursuit of happiness." Such conditions represent the brightest and most potent exponents of a higher civilization, in