tbuckley/cabot-search huggingface dataset:
Orthotopic Heart Transplantation for Congenital Heart Disease: An Alternative for High-Risk Fontan Candidates?
Authors: Guido Michielon, Francesco Parisi, Cosimo Squitieri, Adriano Carotti, Giulia Gagliardi, Luciano Pasquini, Roberto M. Di Donato
Journal: Circulation (2003)

Evaluation of incremental risk factors for early mortality in children undergoing orthotopic heart transplantation (OHT) for congenital heart disease.Between 1988 and 2002, 43 patients (mean age 9.1+/-7.2 years) underwent 44 OHT for complex TGA (6), DORV (4), single ventricle (21), and other end-stage structural heart disease (11). Two discernible ventricular chambers were present in 18 pts (41.8%). Previous reconstructive or palliative procedures had been previously accomplished in 35 pts (83.3%), including atrial switch (5), systemic-to-pulmonary shunts (10), cavopulmonary anastomosis (9), Fontan completion (6), and others (5).30-day survival for the 2-ventricle subgroup was 94.4+/-5.4% compared with 67.2+/-9.5% for the single ventricle subgroup (P=0.04) (overall 78.6%+/-3.3%). OHT following single ventricle staging to bi-directional cavopulmonary anastomosis exhibited 100% early survival, as opposed to 62.5+/-17.1% for OHT after systemic-to-pulmonary shunts, and 33.3+/-19.2% for OHT following failing Fontan (P=0.010). HLHS diagnosis (0.0085) and failing Fontan (P=0.003) were identified as independent predictors of early mortality by regression logistic modeling, while Fontan stage represented the only predictor of overall mortality by Cox proportional hazard. Overall 10-year survival was 54.3+/-11%.OHT for structural congenital heart disease with single ventricle physiology entails substantial early mortality and bi-directional cavopulmonary anastomosis enables the best transition to heart transplant. OHT should be considered in the decision making process as an alternative to Fontan completion in high-risk candidates, since rescue-OHT after failing Fontan seems unwarranted.
Reducing Suicide: A National Imperative
Authors: L. D. Hankoff
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multicentric evaluation of the MDR phenotype in leukemia
Authors: J-P Marie, S Huet, A-M Faussat, J-Y Perrot, S Chevillard, V Barbu, C Bayle, J Boutonnat, F Calvo, L Campos-Guyotat, P Colosetti, J-L Cazin, P de Cremoux, C Delvincourt, C Demur, B Drenou, O Fenneteau, J Feuillard, A Garnier-Suillerot, P Genne, M-C Gorisse, P Gosselin, H Jouault, R Lacave, G Le Calvez, M-C Léglise, S Léonce, M Manfait, M Maynadié, H Merle-Béral, J-L Merlin, M Mousseau, H Morjani, F Picard, F Pinguet, P Poncelet, E Racadot, M Raphael, B Richard, J-F Rossi, N Schlegel, P Vielh, D-C Zhou, J Robert
Journal: Leukemia (1997)
Alexithymia and Depressed Mood in the Psychiatric Patient
Authors: Thomas N. Wise, Lee S. Mann, Bethanne Hill
Journal: Psychotherapy and Psychosomatics (1990)

The relationship between depressed mood and alexithymia, measured by the Toronto Alexithymia Scale (TAS) was investigated in a group of psychiatric inpatients (n = 81) and outpatients (n = 97). In both cohorts correlations between the TAS and obsessoid personality style were significant when controlled for mood. The obsessoid style, measured by the Hysteroid-Obsessoid Scale was the most powerful predictor of alexithymia in regression models for each cohort. These data suggest that alexithymia is not a function of depression in such psychiatric patients.
Mycosis fungoides—response to therapy and survival patterns in 85 cases
Authors: N.J. SLEVIN, V. BLAIR, I.D.H. TODD
Journal: British Journal of Dermatology (1987)

The clinical course and management of 85 cases of mycosis fungoides presenting over a 20-year period are described. The extent of skin involvement and presence of lymphadenopathy were seen to be important prognostic factors. The following survival patterns were observed. In eight cases with limited plaque disease there was prolonged disease-free survival after treatment with kilovoltage X-rays; after a median follow-up of 64 months there was only one case of progression to generalized disease. In 49 cases of generalized skin disease (plaque disease +/- tumours; erythroderma) treated with total skin electron beam therapy there was a 24% 5-year disease-free survival; this potential for long-term survival was seen in cases with generalized plaque disease without lymphadenopathy. The remainder of the cases showed a continuously relapsing course. The extent of skin involvement and presence of lymphadenopathy can both be used as known prognostic factors to adopt a logical plan of treatment.
Dopamine Stimulates Sodium Transport and Liquid Clearance in Rat Lung Epithelium
Authors: MICHELE L. BARNARD, WALTER G. OLIVERA, DAVID M. RUTSCHMAN, ALEJANDRO M. BERTORELLO, A. I. KATZ, JACOB I. SZNAJDER
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Pulmonary edema clearance is driven primarily by active sodium transport out of the alveoli, mediated predominantly by apical sodium channels and the basolateral NA,K-ATPase. We postulated that dopamine, analogous to its effects in other transporting epithelia, could regulate these sodium transport mechanisms and affect lung liquid clearance. We therefore studied the effects of dopamine on sodium transport and liquid clearance in isolated perfused rat lungs. Instillation of dopamine into the airways caused a dose-dependent increase in liquid clearance from isolated rat lungs of up to 33% above control values at 10(-8) to 10(-4) M concentrations. 10(-6) M amiloride, which selectively inhibits apical sodium channels, decreased basal liquid clearance by 34% but did not inhibit the dopamine-mediated stimulation of lung liquid clearance. Instillation of 10(-4) M amiloride into rat airways, which inhibits other sodium transport mechanisms non-selectively, decreased basal lung liquid clearance by 49% and inhibited the dopamine-mediated stimulation of lung liquid clearance. Perfusion of rat lungs with 5 x 10(-4) M ouabain to specifically inhibit Na,K-ATPase reduced both basal clearance (by 55%) and the dopamine-stimulated increase in lung fluid clearance. Conceivably, the stimulation of lung liquid clearance by dopamine is due to a modulation of Na,K-ATPase in the pulmonary epithelium.
CLOSED-CHEST CARDIAC MASSAGE-Reply
Authors: W. B. Kouwenhoven
Journal: JAMA (1960)

<h3>To the Editor:—</h3> Dr. Sauder refers to the efforts of Doctors Rainer and Bullough (<i>Brit. M. J.</i><b>2</b>:1024-1028 [Nov. 2] 1957) to resuscitate children in cardiac arrest by placing one arm underneath the knees and flexing the legs against the chest. They reported eight successful recoveries. Dr. Stout (<i>J. Oklahoma M. Assoc.</i><b>3</b>:112-114 [March] 1957) reported a success with the method in one adult. As Dr. Sauder stated, one would need the strength of Hercules to apply this method to a heavy adult. Fortunately, a Venus has ample strength to maintain adequate circulation during cardiac arrest by applying rhythmic pressures on the sternum.
Three-Gene Expression Signature Predicts Survival in Early-Stage Squamous Cell Carcinoma of the Lung
Authors: Marcin Skrzypski, Ewa Jassem, Miquel Taron, Jose Javier Sanchez, Pedro Mendez, Witold Rzyman, Grazyna Gulida, Dan Raz, David Jablons, Mariano Provencio, Bartomeu Massuti, Imane Chaib, Laia Perez-Roca, Jacek Jassem, Rafael Rosell
Journal: Clinical Cancer Research (2008)

Abstract Purpose: Adjuvant treatment may improve survival in early-stage squamous cell carcinoma (SCC) of the lung; however, the absolute gain is modest and mainly limited to stage II-IIIA. Current staging methods are imprecise indications of prognosis, but high-risk patients can be identified by gene expression profiling and considered for adjuvant therapy. Experimental Design: The expression of 29 genes was assessed by reverse transcriptase quantitative PCR in frozen primary tumor specimens obtained from 66 SCC patients who had undergone surgical resection. Expression values were dichotomized using the median as a cutoff value. We used a risk score to develop a gene expression model for the prediction of survival. Results: The univariate analysis of gene expression in the training cohort identified 10 genes with significant prognostic value: CSF1, EGFR, CA IX, PH4, KIAA0974, ANLN, VEGFC, NTRK1, FN1, and INR1. In the multivariate Cox model, CSF1 (hazard ratio, 3.5; P = 0.005), EGFR (hazard ratio, 2.7; P = 0.02), CA IX (hazard ratio, 0.2; P &amp;lt; 0.0001), and tumor size &amp;gt;4 cm (hazard ratio, 2.7; P = 0.02) emerged as significant markers for survival. The high prognostic value of a risk score based on the expression of the three genes (CSF1, EGFR, and CA IX) was positively validated in a separate cohort of 26 patients in an independent laboratory (P = 0.05). Conclusions: The three-gene signature is strongly associated with prognosis in early-stage SCC. Positive independent validation suggests its suitability for selecting SCC patients with an increased risk of death who might benefit from adjuvant treatment.
Augmentation of mortality risk discriminating power of left ventricular ejection fraction by measures of nonuniformity in systolic emptying on radionuclide ventriculography
Authors: Arnold M. Weissler, Brian I. Miller, Christopher B. Granger, Timothy D. Henry, Khalid H. Sheikh, Dennis L. Kirch, William B. Guess, Barbara J. Krumbach
Journal: Journal of the American College of Cardiology (1990)
Future Opportunities in Cancer Nanotechnology—NCI Strategic Workshop Report
Authors: Piotr Grodzinski, Dorothy Farrell
Journal: Cancer Research (2014)

There has been significant progress in utilizing nanotechnology in several areas of cancer care, including in vitro diagnostics, imaging, and therapy. The National Cancer Institute, which currently supports an array of research activities in cancer nanotechnology, convened a strategic workshop to explore the most promising directions and areas for future resource investment. The major discussion points as well as the opportunities identified are presented herein.
Evaluation of the reimbursement criteria for biological therapies for psoriasis in the Netherlands
Authors: M. Wakkee, H.B. Thio, P.I. Spuls, E.M. de Jong, T. Nijsten
Journal: British Journal of Dermatology (2008)

Journal Article Evaluation of the reimbursement criteria for biological therapies for psoriasis in the Netherlands Get access M. Wakkee, M. Wakkee Department of Dermatology, Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar H.B. Thio, H.B. Thio Department of Dermatology, Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar P.I. Spuls, P.I. Spuls Department of Dermatology, Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar E.M. De Jong, E.M. De Jong Department of Dermatology, Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar T. Nijsten T. Nijsten Department of Dermatology, Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, the Netherlands Correspondence: Tamar Nijsten. E‐mail: t.nijsten@erasmusmc.nl Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 158, Issue 5, 1 May 2008, Pages 1159–1161, https://doi.org/10.1111/j.1365-2133.2008.08512.x Published: 01 May 2008
Claims for Moxalactam
Authors: DAVID A. HERBERT
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 November 1982Claims for MoxalactamDAVID A. HERBERT, M.D.DAVID A. HERBERT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-5-787_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Advertisements have begun to appear in your journal and in other medical journals for moxalactam (Moxam; Eli Lilly and Company, Indianapolis, Indiana), a new "third-generation cephalosporin." An unreferenced statement in these advertisements claims that "Moxam alone was more effective than the combination of gentamicin plus clindamycin" in the treatment of surgical infections. However, if one examines the study on which this claim is based (1), somewhat different conclusions are apparent. In a randomized study 156 patients received either moxalactam or gentamicin plus clindamycin, and "elimination of sepsis was achieved in only 57% of those given gentamicin-clindamycin, as...References1. STROMSTONEFABIAN PHT. Moxalactam versus gentamicin-clindamycin for the treatment of infections within the abdominal cavity. Contemp Surg. 1982;20:39-42. Google Scholar2. APPELNEU GH. Gentamicin in 1978. Ann Intern Med. 1978;89:528-38. LinkGoogle Scholar3. ZASKECIPOLLESTRATE DRR. Gentamicin dosage requirements: wide interpatient variations in 242 surgery patients with normal renal function. Surgery. 1980;87:164-9. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Southern California Medical Center Bellflower, CA 90706 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1982Volume 97, Issue 5Page: 787-788KeywordsClindamycinSepsis Issue Published: 1 November 1982 PDF DownloadLoading ...
Impaired oxygen utilization. A new mechanism for the hepatotoxicity of ethanol in sub-human primates.
Authors: C S Lieber, E Baraona, R Hernández-Muñoz, S Kubota, N Sato, S Kawano, T Matsumura, N Inatomi
Journal: Journal of Clinical Investigation (1989)

The role of oxygenation in the pathogenesis of alcoholic liver injury was investigated in six baboons fed alcohol chronically and in six pair-fed controls. All animals fed alcohol developed fatty liver with, in addition, fibrosis in three. No evidence for hypoxia was found, both in the basal state and after ethanol at moderate (30 mM) or high (55 mM) levels, as shown by unchanged or even increased hepatic venous partial pressure of O2 and O2 saturation of hemoglobin in the tissue. In controls, ethanol administration resulted in enhanced O2 consumption (offset by a commitant increase in splanchnic blood flow), whereas in alcohol fed animals, there was no increase. At the moderate ethanol dose, the flow-independent O2 extraction, measured by reflectance spectroscopy on the liver surface, tended to increase in control animals only, whereas a significant decrease was observed after the high ethanol dose in the alcohol-treated baboons. This was associated with a marked shift in the mitochondrial redox level in the alcohol-fed (but not in control) baboons, with striking rises in splanchnic output of glutamic dehydrogenase and acetaldehyde, reflecting mitochondrial injury. Increased acetaldehyde, in turn, may aggravate the mitochondrial damage and exacerbate defective O2 utilization. Thus impaired O2 consumption rather than lack of O2 supply characterizes liver injury produced by high ethanol levels in baboons fed alcohol chronically.
A Nosocomial Outbreak of Fluoroquinolone-Resistant Salmonella Infection
Authors: Sonja J. Olsen, Emilio E. DeBess, Teresa E. McGivern, Nina Marano, Tom Eby, Steve Mauvais, Vijay K. Balan, Gerald Zirnstein, Paul R. Cieslak, Frederick J. Angulo
Journal: New England Journal of Medicine (2001)

Infection with fluoroquinolone-resistant strains of salmonella is rare, as is nosocomial salmonella infection. We describe the first recognized outbreak of fluoroquinolone-resistant salmonella infections in the United States, which occurred in two nursing homes and one hospital in Oregon.We interviewed medical staff and reviewed patients' charts and death certificates. In Nursing Home A we conducted a case-control study. Patients were defined as residents of the nursing home from whom fluoroquinolone-resistant Salmonella enterica serotype Schwarzengrund was isolated between February 1996 and December 1998. Controls were residents with similar medical conditions whose cultures did not yield salmonella. We compared isolates using pulsed-field gel electrophoresis and sequence analysis. We reviewed pharmacy records to compare the use of fluoroquinolone among several nursing homes.Eleven patients with fluoroquinolone-resistant salmonellosis were identified at two nursing homes. The index patient had been hospitalized in the Philippines and had probably acquired the infection there. Transmission was probably direct (from patient to patient) or through contact with contaminated surfaces. Treatment with fluoroquinolones during the six months before a culture was obtained was associated with a significant risk of salmonella infection (4 of 5 patients had taken fluoroquinolones, as compared with 2 of 13 controls; odds ratio, 22.0; 95 percent confidence interval, 1.06 to 1177). The patients were not significantly more likely than the controls to have taken other antibiotics. More fluoroquinolones were used at Nursing Home A than at similar nursing homes in Oregon. The isolates from the outbreak had similar patterns on pulsed-field gel electrophoresis and the same gyrA mutations. The isolates from the outbreak were also similar to the only previous isolate of fluoroquinolone-resistant salmonella in the United States, which came from a patient in New York who had been transferred from a hospital in the Philippines.We describe a prolonged nosocomial outbreak of infection with fluoroquinolone-resistant S. enterica serotype Schwarzengrund. More such outbreaks are likely in institutional settings, particularly those in which there is heavy use of antimicrobial agents.
On the Influence of Vitality upon the Excretions
Authors: T. Inman
Journal: BMJ (1859)

CASE iII.A gentleman, some time since under my treat- nment for stricture, informed me that he could not eat figs without experiencing a most unpleasant formication of the palate and fauces; and that the fine dust from split peas pro- duced the same sensation, accompanied by a running at the nose.The father of this gentleman suffers from hay-fever at certain seasons.CASE IV.Mlr.P., himself a gentleman of a peculiarly nervous temperamnent, states that his father cannot endure the sensa- tion produced by handling a russet apple.He also communi- cated to me CASE v-that of Mr. T., who cannot remain in a room in which there is a cooked hare, on account of the peculiar effect produced on his system.CASE VI.Miss -, after eating egg, suffers from swellinof the ton,ue and throat, accompanied by " alarming illness".CASE VII.Miss -.In this case, somewhat similar effects follow the taking of honey of any kind, and especially honey- comb, into the stomach; viz., swelling of the tongue, frothing of the mouth, and blueness of the finaers.CASE vIII.The following is an extract from a note received by ine fromii a lady, wh6 says:-" I had on three mustard plaisters-one on the thlroat, one on the back of the neck, and another under the left shoulder.They remained on half an hiour.Cotton wNool wvas applied on their removal.About thirty hours afterwards, a painful stinging sensation commenced in the back of the neck, followed by violent twitching of the muscles of the face, arms, and legs, whiich continued in regular succes- sion tlhrough the whole night.It yielded, after about twelve hours, to hot fomentations of poppy-heads applied to the back of the neck."It cannot be ascertained that any medicine con.taining strychnia was taken.CASE Ix.A gentleman, a member of the medical profession, -with wlhom 1 am well acquainted, suffers from nettle-rash after eating veal.Vleal has the reputation of being particularly indi- gestible.The above instance of the production of urticaria from its use is, doubtless, not an uncommon one.CASE X.I have been informed of a lady who cannot remain .ina room in which there is a cat.Although the cat may be eoncealed, the lady's peculiar sensations immediately declare to her the presence of the animal.CASE xI.A patient under my care, since dead of cancer, was invariably thrown into a state of nervous excitement by the exliibition of the compound infusion of orange-peel.CASE xII.A personal friend of my own suffered from erythema nodosum after eating shrimps, although these were perfectly fresh.I believe shell-fish generally is particularly liable to excite unpleasant consequences.It would be useful, I venture to suggest, if other members of the Association would contribute any instances of idiosyncratic poisoning they may lknow; since, from a multiplicity of ex- ceptions, some general rule may be educed.8, Stratford Place, W.,