tbuckley/cabot-search huggingface dataset:
Using Community-Based Participatory Research to Ask and Answer Questions Regarding the Environment and Health
Authors: Mary E. Northridge, Katherine Shoemaker, Betina Jean-Louis, Benjamin Ortiz, Rachel Swaner, Roger D. Vaughan, Linda F. Cushman, Vincent E. Hutchinson, Stephen W. Nicholas
Journal: Environmental Health Perspectives (2005)

In 1991 Dr. Kenneth Olden became the first AfricanAmerican director of an institute in the National Institutes of Health (NIH) when he assumed the leadership of the National Institute of Environmental Health Sciences (NIEHS) (Brown 2004). That same year, the NIEHS—with Dr. Olden in prominent attendance—hosted the Interagency Symposium on Health Research Needs to Ensure Environmental Justice, which was held 11 February 1994 in Arlington, Virginia (Shepard et al. 2002). Throughout his tenure at the helm of NIEHS, Dr. Olden has listened to the needs, both small and large, of communities that have experienced severe disparities in both environmental exposures and health outcomes. This E s s a y o n Community-Based Participatory Research
Open access mammography.
Authors: A. E. Young
Journal: BMJ (1992)

difficult, is one based on the balance of proba- bilities.More research is required and should focus on the general concept of work related disorders rather than be confined to the upper limb.If health promotion is to mean anything it should mean that going to work tends to engender fitness.This is why unemployment is considered to be bad for society in general and individual workers in particular.A more positive attitude should be taken towards work, and this should be embodied in the concept that to work is to keep fit.No one would suggest that all pain at work was caused by the work itself: it may be caused by sports injuries acquired over a weekend or be part of intercurrent disease.Hence the importance of the therapeutic test of altering circumstances at work to see if the symptoms remit.With the implementation of the European Com- munity's regulations for workers the medical professions and ergonomists will have to cooperate if pains are to be prevented.Staff working in district rheumatological, orthopaedic, and remedial ser- vices should work more closely with occupational physicians and ergonomists.Perhaps it is time for a combined medicoergonomics society.
Democratisation of scientific advice
Authors: Roland Bal, Wiebe E Bijker, Ruud Hendriks
Journal: BMJ (2004)

Dutch experience shows how scientific advisory bodies can cope with the growing political demands for transparency and lay participation without compromising their function Scientific advisory councils in Western countries have become increasingly confronted with demands that are usually reserved for the political arena. 1 2 Two such demands stand out: transparency and public participation.Although these seem legitimate demands, and have been taken up by governments in most democratic countries, it is unclear how they can be enacted or what their effects will be on the advisory process.Open and closed procedures are conventionally viewed as opposites. 3 4 We argue that they have a dialectic relation and are not mutually exclusive, using the example of the Health Council of the Netherlands.Ordinary people are often the best judge of their own needs
Cyclin D1 Overexpression in Bronchial Epithelia of Patients With Lung Cancer Is Associated With Smoking and Predicts Survival
Authors: D. Ratschiller, J. Heighway, M. Gugger, A. Kappeler, F. Pirnia, R.A. Schmid, M.M. Borner, D.C. Betticher
Journal: Journal of Clinical Oncology (2003)

Purpose: Cyclin D1 is overexpressed in almost 60% of resectable non–small-cell lung cancer (NSCLC). In the absence of cyclin D1 gene amplification, overexpression is characterized by allelic imbalanced transcript levels. Methods: The aims were to study cyclin D1 expression by immunohistochemistry and allelic balance of transcripts in tumor-free bronchial epithelia from patients with resectable NSCLC by using monoclonal antibodies (48 patients and 288 sites), microdissection/reverse transcriptase polymerase chain reaction/restriction fragment length polymorphism analyses (24 patients and 144 sites). Derived data were related to patient characteristics—in particular, smoking habits. Results: In 167 (58%) of 288 sites, cyclin D1 was overexpressed, with cytoplasmic and nuclear sublocalization in 53% and 7% of all sites, respectively. Nuclear overexpression was more frequent in premalignant versus normal or hyperplastic epithelia (55% v 3%; P &lt; .0001). Allele-specific expression imbalances were found in 69 (48%) of 144 sites; in particular, those in which cyclin D1 was overexpressed (P = .004). In 14 (58%) of 24 patients, balanced or imbalanced transcript ratios and degree of expression were consistent at all sites for the same patient, whereas in another 10 patients, transcript balances and cyclin D1 expression patterns varied across the sites. Nuclear cyclin D1 expression in at least one site (14 of 48 patients) was linked to heavy smoking (&gt; 40 pack-years; P = .02) and shorter overall survival (P = .01). Conclusion: Allele-specific, probably damage-driven, deregulation of the cyclin D1 gene may precede and perhaps facilitate the spread of preneoplastic clones across the bronchial epithelial surface in a significant number of patients. Cyclin D1 expression at multiple bronchial sites may identify a subgroup of heavy-smoking patients with poor outcome.
GW25-e3246 Expressions of tnfsf6 and cyp1a1 and screening related genes by GeneChip on peripheral blood mononuclear cells in patients with Acute Myocardial Infarction
Authors: Zhan Hong, Xiong Yan, Cai Ruibing, Ye Zi, Xu Jia, Jiang Peng, Chen Yuemei, Zhou Yijun Karamath, Ma Zhongfu
Journal: Journal of the American College of Cardiology (2014)
AB0103 Tacrolimus Inhibit IL-1β and ER Stress-Induced, Rankl-Mediated Osteoclastogenesis by Inhibiting Perk, Ire1, Grp78, Eif2a, C-Fos and Nfatc1
Authors: W.-S. Lee, E.-G. Lee, M.-S. Sung, C.-H. Lee, M.-S. Lee, W.-H. Yoo
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Tacrolimus (TAC) is a T cell specific, anti-inflammatory agent that has been used as a therapeutic agent for rheumatoid arthritis (RA). IL-1β and thapsigargin (TG)-induced endoplasmic reticulum (ER) stress modulate the receptor activator of nuclear factor kappa-B ligand (RANKL)-mediated osteoclastogenesis. <h3>Objectives</h3> This study was investigated to define the effects of TAC on IL-1β and ER stress-induced, RANKL-mediated osteoclastogenesis and its mechanisms. <h3>Methods</h3> Bone marrow cells (BMCs) were obtained from 5-week-old male ICR mice and cultured to be differentiated into osteoclasts with M-CSF and RANKL in the presence or absence of IL-1β, TG, or TAC. The formation of osteoclasts was evaluated by tartrate-resistant acid phosphatase (TRAP) staining and resorption pit assay with dentine slice. The molecular mechanisms of the above effects of TAC on osteoclastogenesis were investigated by using RT-PCR and immunoblotting for osteoclast specific and ER stress signaling molecules, including PERK, IRE1, GRP78, eIF2α, c-Fos and NFATc1. <h3>Results</h3> IL-1β and TG-induced ER stress increased the formation of osteoclasts by up-regulating the osteoclast specific signals (c-Fos, NFATc1) and ER stress-associated signaling pathways (PERK, IRE1, GRP78, and eIF2α). TAC significantly inhibited IL-1β and ER stress-induced, RANKL-mediated osteoclastogenesis by down-regulating above signal pathways, dose-dependently. <h3>Conclusions</h3> TAC inhibited IL-1β and ER stress-induced, RANKL-mediated osteoclastogenesis by inhibiting intracellular signaling pathways, including PERK, IRE1, GRP78, c-Fos and NFATc1. These results suggest that TAC might have disease modifying effects by inhibition of inflammation and ER stress-induced osteoclastogenesis in the inflammatory joint diseases, such as RA. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4216
Twenty-Four–Hour Holter Monitor Follow-Up Does Not Provide Accurate Heart Rhythm Status After Surgical Atrial Fibrillation Ablation Therapy
Authors: Thorsten Hanke, Efstratios I. Charitos, Ulrich Stierle, Antje Karluss, Ernst Kraatz, Bernhard Graf, Axel Hagemann, Martin Misfeld, Hans H. Sievers
Journal: Circulation (2009)

Twenty-four-hour Holter monitoring (24HM) is commonly used to assess cardiac rhythm after surgical therapy of atrial fibrillation (AF). However, this "snapshot" documentation leaves a considerable diagnostic window and only stores short-time cardiac rhythm episodes. To improve accuracy of rhythm surveillance after surgical ablation therapy and to compare continuous heart rhythm surveillance versus 24HM follow-up intraindividually, we evaluated a novel implantable continuous cardiac rhythm monitoring (IMD) device (Reveal XT 9525).Forty-five cardiac surgical patients (male 37, mean age 69.7+/-9.2 years) with a mean preoperative AF duration of 38+/-45 m were treated with either left atrial epicardial high-intensity focus ultrasound ablation (n=33) or endocardial cryothermy (n=12) in case of concomitant mitral valve surgery. Rhythm control readings were derived simultaneously from 24HM and IMD at 3-month intervals with a total recording of 2021 hours for 24HM and 220 766 hours for IMD. Mean follow-up was 8.30+/-3.97 m (range 0 to 12 m). Mean postoperative AF burden (time period spent in AF) as indicated by IMD was 37+/-43%. Sinus rhythm was documented in 53 readings of 24HM, but in only 34 of these instances by the IMD in the time period before 24HM readings (64%, P<0.0001), reflecting a 24HM sensitivity of 0.60 and a negative predictive value of 0.64 for detecting AF recurrence.For "real-life" cardiac rhythm documentation, continuous heart rhythm surveillance instead of any conventional 24HM follow-up strategy is necessary. This is particularly important for further judgment of ablation techniques, devices as well as anticoagulation and antiarrhythmic therapy.
Subclinical Disease as an Independent Risk Factor for Cardiovascular Disease
Authors: L.H. Kuller, L. Shemanski, B.M. Psaty, N.O. Borhani, J. Gardin, M.N. Haan, D.H. O’Leary, P.J. Savage, G.S. Tell, R. Tracy
Journal: Circulation (1995)

The primary aim of the present study was to determine the relation between measures of subclinical cardiovascular disease and the incidence of clinical cardiovascular disease among 5201 adults 65 years of age or older who were participating in the Cardiovascular Health Study.A new method of classifying subclinical disease at baseline examination in the Cardiovascular Health Study included measures of ankle-brachial blood pressure, carotid artery stenosis and wall thickness, ECG and echocardiographic abnormalities, and positive response to the Rose Angina and Claudication Questionnaire. Participants were followed for an average of 2.39 years (maximum, 3 years). For participants without evidence of clinical cardiovascular disease at baseline, the presence of subclinical disease compared with no subclinical disease was associated with a significant increased risk of incident total coronary heart disease including CHD deaths and nonfatal MI and angina pectoris for both men and women. For individuals with subclinical disease, the increased risk of total coronary heart disease was 2.0 for men and 2.5 for women, and the increased risk of total mortality was 2.9 for men and 1.7 for women. The increased risk changed little after adjustment for other risk factors, including lipoprotein levels, blood pressure, smoking, and diabetes.The measurement of subclinical disease provides an approach for identifying high-risk older individuals who may be candidates for more active intervention to prevent clinical disease.
Where are the medical voices raised in protest?
Authors: Ian Greener
Journal: BMJ (2006)

A neuran Bevan, having to create the NHS in the face of medical opposition, famously claimed to have stuffed consultants' mouths with gold, splitting the medical profession and giving himself the leverage to create the health service he envisaged. The GPs continued to resist Bevan's plans over concerns that he might try to make their profession salaried, but on the appointed day the NHS appeared as promised. The health service was founded on the principle (or “concordat”) that the government would fund health care but leave its operational running to the doctors.

> Doctors say they no longer have the will or power to stop reforms 

Nearly 60 years later we find ourselves with a government committed to changing Bevan's NHS to a form its founder would surely struggle to recognise. The medical professions—such hard negotiators during the NHS's creation—have become the ones we look to first to preserve what is valuable in the NHS. The doctors, through the royal colleges and the BMA, have a long history of blocking reform that could damage their professional interests or that might adversely affect patient care. In the …
Ingestion of a Glucose Syrup Drink during long distance canoeing
Authors: L. F. Green, R. Bagley
Journal: British Journal of Sports Medicine (1972)

The use of a drink containing glucose syrup and mineral salts has been compared with a placebo in a group of eight long-distance canoeists under simulated race conditions. The findings suggest that maintenance of blood glucose above fasting level during severe exercise prevents both a deterioration of performance and prolonged post-exercise exhaustion. There was no evidence to suggest that the benefits were psychological in nature.
Preventing twists, turns on road to medical education from becoming permanent detours
Authors: C. Raymond
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Controlling Gastric Acid
Authors: G. Dickson, C. W. Jamieson
Journal: BMJ (1971)

It Selective vagotomy no pyloroplasty no stenosis _ O [ 2 ++ 3 -+ + + 4 0 0 0 5 + 0 0 6 + .00 ~7 0 !12 3 + + 0+ 0 0 14 0 15 ~+ 0 17 0 18 _ °O 0 14 0 0 0_ lb + O~+O_ 70 01 0 0 3 6 12 months afteroperation so long as nerve section is complete and the nerves of Latarjet properly preserved.It is a very much better operation than bilateral selective vagotomy without drainage for it can be used in the presence of organic duo- denal narrowing.Probably only in advanced duodenal stenosis is a drainage operation required.-Iam, etc.,
Multiple distinct small RNAs originate from the same microRNA precursors
Authors: Weixiong Zhang, Shang Gao, Xuefeng Zhou, Jing Xia, Padmanabhan Chellappan, Xiang Zhou, Xiaoming Zhang, Hailing Jin
Journal: Genome biology (2010)

MicroRNAs (miRNAs), which originate from precursor transcripts with stem-loop structures, are essential gene expression regulators in eukaryotes. We report 19 miRNA precursors in Arabidopsis that can yield multiple distinct miRNA-like RNAs in addition to miRNAs and miRNA*s. These miRNA precursor-derived miRNA-like RNAs are often arranged in phase and form duplexes with an approximately two-nucleotide 3'-end overhang. Their production depends on the same biogenesis pathway as their sibling miRNAs and does not require RNA-dependent RNA polymerases or RNA polymerase IV. These miRNA-like RNAs are methylated, and many of them are associated with Argonaute proteins. Some of the miRNA-like RNAs are differentially expressed in response to bacterial challenges, and some are more abundant than the cognate miRNAs. Computational and expression analyses demonstrate that some of these miRNA-like RNAs are potentially functional and they target protein-coding genes for silencing. The function of some of these miRNA-like RNAs was further supported by their target cleavage products from the published small RNA degradome data. Our systematic examination of public small-RNA deep sequencing data from four additional plant species (Oryza sativa, Physcomitrella patens, Medicago truncatula and Populus trichocarpa) and four animals (Homo sapiens, Mus musculus, Caenorhabditis elegans and Drosophila) shows that such miRNA-like RNAs exist broadly in eukaryotes. We demonstrate that multiple miRNAs could derive from miRNA precursors by sequential processing of Dicer or Dicer-like proteins. Our results suggest that the pool of miRNAs is larger than was previously recognized, and miRNA-mediated gene regulation may be broader and more complex than previously thought.
Abstract 3213: A rapid, sensitive and quantitative method to measure protein biomarkers MUC16 and MSLN from archived clinical samples using TaqMan proximity ligation assays.
Authors: Lisa Ryner, Aimee Fourie, Siao Ping Tsai, Suzie Scales, Kathy Kozak, Ron Firestein, Yinghui Guan, An Do, Yulei Wang
Journal: Cancer Research (2013)

Abstract MUC16 and MSLN are tumor-specific antigens highly prevalent in ovarian and pancreatic cancers and have been used as targets in developing antibody-drug conjugates (ADCs). Development of a sensitive method to quantitatively measure these protein biomarkers in archival clinical samples may enable potential companion diagnostics to these novel therapeutic agents. Here we report the development of a method to quantitatively measure these biomarkers from formalin fixed paraffin embedded (FFPE) tumor samples using TaqMan proximity ligation assays (PLA). Monoclonal antibodies that recognize the extracellular domains of MUC16 and MSLN were conjugated to amplicon forming oligonucleotides to generate proximity ligation probes for TaqMan quantification. Using purified MUC16 and MSLN recombinant protein the assay sensitivities were determined to be lower than single-digit ng/mL concentrations for both MUC16 and MSLN and the dynamic ranges were &amp;gt;3 logs and ∼2 logs, respectively. In addition, the assays were demonstrated to be highly selective by testing lysates from expressing and non-expressing cell lines as determined by qRT-PCR. For clinical application of these assays, we further developed and optimized a simple two-step method for extraction and antigen retrieval of protein from archival FFPE tissues. FFPE extracts were prepared from a set of 10um sections of ovarian tumor tissue blocks and analyzed to determine relative MUC16 and MSLN protein expression levels. We benchmarked these results from the FFPE protocol with PLA data generated from matched fresh frozen tumor tissue as well as expression level determined by immunohistochemistry (IHC) and gene expression level determined by qRT-PCR assays from the same FFPE tissue blocks. All three comparisons with FFPE PLA were remarkably well correlated. In conclusion, we have established the technical feasibility and clinical utility of TaqMan PLA-based protein assays for sensitive and quantitative measurement of protein biomarkers in archival clinical samples. The methodology developed in this study represents a promising approach in companion diagnostic development for quantitative protein biomarker assessment. Citation Format: Lisa Ryner, Aimee Fourie, Siao Ping Tsai, Suzie Scales, Kathy Kozak, Ron Firestein, Yinghui Guan, An Do, Yulei Wang. A rapid, sensitive and quantitative method to measure protein biomarkers MUC16 and MSLN from archived clinical samples using TaqMan proximity ligation assays. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3213. doi:10.1158/1538-7445.AM2013-3213
Listeria monocytogenes (Lm)-LLO immunotherapies reduce the immunosuppressive activity of myeloid-derived suppressor cells and regulatory T cells in the tumor microenvironment
Authors: Anu Wallecha, Inga Malinina, Poonam Molli
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg) are major components of the immune suppressive cells that potentially limit the effectiveness of an immunotherapy-based treatment. Both of these suppressive cell types have been shown to expand in tumor models
Can general practitioners compete with big business?: Changing drivers in the NHS
Authors: Elizabeth D Barrett
Journal: BMJ (2006)

EDITOR—The Langwith case reached the High Court over whether there was an obligation to activate section 11 of the 2001 Health and Social Care Act, in this particular case.1 The act states, among other things, that patients should be involved in the development and consideration of proposals for changes in the “way” in which their services are provided.

The national debate on privatisation is a separate …
Malignant pleomorphic parotid adenoma with inflammatory cutaneous metastasis
Authors: E. Soler, L. Borrego, J. Hbrnandez-Santana, V. Castro, J. Rodriguez, B. Hernandez-Hernandez
Journal: British Journal of Dermatology (1996)

Journal Article Malignant pleomorphic parotid adenoma with inflammatory cutaneous metastasis Get access E. Soler, E. Soler Departments of Dermatology, Hospital Inular, Avda Dr Pasteur, 35016 Las Palmas de Gran Canaria, Spain Search for other works by this author on: Oxford Academic Google Scholar L. Borrego, L. Borrego Departments of Dermatology, Hospital Inular, Avda Dr Pasteur, 35016 Las Palmas de Gran Canaria, Spain Search for other works by this author on: Oxford Academic Google Scholar J. Hbrnandez‐Santana, J. Hbrnandez‐Santana Departments of Dermatology, Hospital Inular, Avda Dr Pasteur, 35016 Las Palmas de Gran Canaria, Spain Search for other works by this author on: Oxford Academic Google Scholar V. Castro, V. Castro Departments of Dermatology, Hospital Inular, Avda Dr Pasteur, 35016 Las Palmas de Gran Canaria, Spain Search for other works by this author on: Oxford Academic Google Scholar J. Rodriguez, J. Rodriguez Departments of Pathology, Hospital Inular, Avda Dr Pasteur, 35016 Las Palmas de Gran Canaria, Spain Search for other works by this author on: Oxford Academic Google Scholar B. Hernandez‐Hernandez B. Hernandez‐Hernandez Departments of Dermatology, Hospital Inular, Avda Dr Pasteur, 35016 Las Palmas de Gran Canaria, Spain Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 134, Issue 1, 1 January 1996, Pages 190–192, https://doi.org/10.1111/j.1365-2133.1996.tb07874.x Published: 01 January 1996
The effect of desmopressin on platelet function: a selective enhancement of procoagulant COAT platelets in patients with primary platelet function defects
Authors: Giuseppe Colucci, Monika Stutz, Sophie Rochat, Tiziana Conte, Marko Pavicic, Marianne Reusser, Evelyne Giabbani, Anh Huynh, Charles Thürlemann, Peter Keller, Lorenzo Alberio
Journal: Blood (2014)