tbuckley/cabot-search huggingface dataset:
A Novel Bispecific, Trivalent Antibody Construct for Targeting Pancreatic Carcinoma
Authors: David V. Gold, David M. Goldenberg, Habibe Karacay, Edmund A. Rossi, Chien-Hsing Chang, Thomas M. Cardillo, William J. McBride, Robert M. Sharkey
Journal: Cancer Research (2008)

Abstract Preclinical and clinical studies have demonstrated the application of radiolabeled mAb-PAM4 for nuclear imaging and radioimmunotherapy of pancreatic carcinoma. We have now examined the ability of a novel PAM4-based, bispecific monoclonal antibody (mAb) construct, TF10, to pretarget a radiolabeled peptide for improved imaging and therapy. TF10 is a humanized, bispecific mAb, divalent for mAb-PAM4 and monovalent for mAb-679, reactive against the histamine-succinyl-glycine hapten. Biodistribution studies and nuclear imaging of the radiolabeled TF10 and/or TF10-pretargeted hapten-peptide (IMP-288) were conducted in nude mice bearing CaPan1 human pancreatic cancer xenografts. 125I-TF10 cleared rapidly from the blood, with levels decreasing to &amp;lt;1% injected dose per gram (ID/g) by 16 hours. Tumor uptake was 3.47 ± 0.66% ID/g at this time point with no accumulation in any normal tissue. To show the utility of the pretargeting approach, 111In-IMP-288 was administered 16 hours after TF10. At 3 hours postadministration of radiolabeled peptide, imaging showed intense uptake within the tumors and no evidence of accretion in any normal tissue. No targeting was observed in animals given only the 111In-peptide. Tumor uptake of the TF10-pretargeted 111In-IMP-288 was 24.3 ± 1.7% ID/g, whereas for 111In-IMP-288 alone it was only 0.12 ± 0.002% ID/g at 16 hours. Tumor/blood ratios were significantly greater for the pretargeting group (∼1,000:1 at 3 hours) compared with 111In-PAM4-IgG (∼5:1 at 24 hours; P &amp;lt; 0.0003). Radiation dose estimates suggested that TF10/90Y-peptide pretargeting would provide a greater antitumor effect than 90Y-PAM4-IgG. Thus, the results suggest that TF10 pretargeting may provide improved imaging for early detection, diagnosis, and treatment of pancreatic cancer as compared with directly radiolabeled PAM4-IgG. [Cancer Res 2008;68(12):4819–26]
Growth advantage of chronic myeloid leukemia CFU-GM in vitro : survival to growth factor deprivation, possibly related to autocrine stimulation, is a more common feature than hypersensitivity to GM-CSF/IL3 and is efficiently counteracted by retinoids ± α-interferon
Authors: D Ferrero, C Foli, F Giaretta, C Argentino, C Rus, A Pileri
Journal: Leukemia (2001)
Interdependence of intracellular taurine and sodium in guinea pig heart
Authors: M.-S. Suleiman, G. C Rodrigo, R. A Chapman
Journal: Cardiovascular Research (1992)

Journal Article Interdependence of intracellular taurine and sodium in guinea pig heart Get access Moh'd-Saadeh Suleiman, Moh'd-Saadeh Suleiman British Heart Foundation Research Group in Cellular Cardiology, Department of Physiology, School of Veterinary Science, University of Bristol, Park Row, Bristol BSl 5LS, United Kingdom: M-S Suleiman, G C Rodrigo, R A Chapman. Correspondence to Professor Chapman. Search for other works by this author on: Oxford Academic PubMed Google Scholar Glenn C Rodrigo, Glenn C Rodrigo British Heart Foundation Research Group in Cellular Cardiology, Department of Physiology, School of Veterinary Science, University of Bristol, Park Row, Bristol BSl 5LS, United Kingdom: M-S Suleiman, G C Rodrigo, R A Chapman. Search for other works by this author on: Oxford Academic PubMed Google Scholar Reg A Chapman Reg A Chapman British Heart Foundation Research Group in Cellular Cardiology, Department of Physiology, School of Veterinary Science, University of Bristol, Park Row, Bristol BSl 5LS, United Kingdom: M-S Suleiman, G C Rodrigo, R A Chapman. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 9, September 1992, Pages 897–905, https://doi.org/10.1093/cvr/26.9.897 Published: 01 September 1992 Article history Received: 07 November 1991 Accepted: 11 March 1992 Published: 01 September 1992
Induction of Cytoplasmic Accumulation of p53: A Mechanism for Low Levels of Arsenic Exposure to Predispose Cells for Malignant Transformation
Authors: Yelin Huang, Jianglin Zhang, Kevin T. McHenry, Mihee M. Kim, Weiqi Zeng, Vanessa Lopez-Pajares, Christian C. Dibble, Joseph P. Mizgerd, Zhi-Min Yuan
Journal: Cancer Research (2008)

Abstract Although epidemiologic studies have linked arsenic exposure to the development of human cancer, the mechanisms underlying the tumorigenic role of arsenic remain largely undefined. We report here that treatment of cells with sodium arsenite at the concentrations close to environmental exposure is associated with the up-regulation of Hdm2 and the accumulation of p53 in the cytoplasm. Through the mitogen-activated protein kinase pathway, arsenite stimulates the P2 promoter–mediated expression of Hdm2, which then promotes p53 nuclear export. As a consequence, the p53 response to genotoxic stress is compromised, as evidenced by the impaired p53 activation and apoptosis in response to UV irradiation or 5FU treatment. The ability of arsenite to impede p53 activation is further demonstrated by a significantly blunted p53-dependent tissue response to 5FU treatment when mice were fed with arsenite-containing water. Together, our data suggests that arsenic compounds predispose cells to malignant transformation by up-regulation of Hdm2 and subsequent p53 inactivation. [Cancer Res 2008;68(22):9131–6]
The Psychosomatic Key as a Core Approach to the Modern Plagues of Mankind
Authors: Luigi Oreste Speciani
Journal: Psychotherapy and Psychosomatics (1979)

The severest plagues of mankind today, from myocardial infarction to cancer, are rising exponentially the world over. For the mechanistic medical science they are mostly 'mystery diseases', as well as a mystery is their uncontrolled exponential trend. Statistics reveal that they rise higher, the more a community is developed. But why? The too easy excuse of a higher 'concrete' pollution seems unreliable, where significant difference rates are recorded by different human groups in the same environment, but exposed to different values of 'psychosomatic involvement', or ΔΨ. The latter symbol, meaning 'the variation of Ψ tone induced by a stimulus-event', belongs to a highly predictive system of quantitative psychosomatics, which enables – through a logico-mathematical tool – the ascertaining of personal levels of ΔΨ. Since a chronic exceeding of its tolerance threshold seems to give rise to the whole set of psychosomatic diseases, cancer perhaps included, it is suggested that the said system may help in diagnostically clearing the matter, perhaps also in controlling it.
Obstacles Predicting Lack of a Regular Provider and Delays in Seeking Care for Patients at an Urban Public Hospital
Authors: Kimberly J. Rask
Journal: JAMA (1994)

<h3>Objective.</h3> —To determine the correlation among obstacles to medical care, lack of a regular source of care, and delays in seeking care. <h3>Design.</h3> —Cross-sectional survey of patients presenting for ambulatory care during a 7-day period. Multiple logistic regression models were used to identify obstacles independently associated with outcome variables. <h3>Setting.</h3> —Urban public hospital. <h3>Patients.</h3> —A total of 3897 disadvantaged and predominantly minority patients. <h3>Main Outcome Measures.</h3> —Lack of a regular source of medical care and delay in seeking medical care for a new problem. <h3>Results.</h3> —The majority (61.6%) of patients reported no regular source of care. Of 2341 patients reporting a new medical problem, 48.4% waited more than 2 days before seeking medical care. No health insurance (adjusted odds ratio [OR], 2.2; 95% confidence interval [CI], 1.89 to 2.61), no transportation (OR, 1.44; 95% CI, 1.23 to 1.70), exposure to violence (OR, 1.21; 95% CI, 1.08 to 1.45), and living in a supervised setting (OR, 1.50; 95% CI, 1.00 to 2.25) were independent predictors of lack of a regular source of care. No insurance (OR, 1.24; 95% CI, 1.02 to 1.51), no transportation (OR, 1.45; 95% CI, 1.19 to 1.77), and less than a high school education (OR, 1.22; 95% CI, 1.08 to 1.49) were independent predictors of delaying care for a new medical problem. <h3>Conclusions.</h3> —Obstacles in addition to lack of insurance impede provision of medical care to disadvantaged patients. The adoption of universal health care coverage alone will not guarantee access to appropriate medical care. (<i>JAMA</i>. 1994;271:1931-1933)
A 17-Year-Old Mother Seeking Contraception
Authors: David A. Grimes
Journal: JAMA (1996)

<h3>Dr DALEY:</h3> Ms B is a 17-year-old student and mother of a 3-year-old daughter who desires to avoid pregnancy. She lives in Boston with her mother and attends a high school program for students with children. Her health care insurance is through the Massachusetts Medicaid program. Ms B became sexually active at 12 years of age and presented to her primary care physician, Dr J, within 2 months of becoming sexually active requesting contraception. A combination oral contraceptive (norethindrone [1 mg] and ethinyl estradiol [35 μg]) was prescribed. At age 13, the patient became pregnant and had an uneventful pregnancy resulting in the birth of a healthy daughter. At the first postnatal visit, the patient reported being sexually active and was not using contraception. The same oral contraceptive was again prescribed, which the patient used for only 2 months. The patient was also treated for a cervical chlamydial infection. Depot
Transparency in the Delivery of Mental Health Care
Authors: Jared T. Ritter
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Conscientious objection in medicine: The ethics of responding to bird flu
Authors: Elizabeth Murray, Paquita de Zulueta
Journal: BMJ (2006)

EDITOR—We question Savulescu's statement that a specialist valuing her own life more than her duty to her patients during a bird flu epidemic would be demonstrating values “incompatible with being a doctor.”1

By 6 February 2006 the World Health Organization had received reports of 165 confirmed cases of avian influenza …
Changes in Attitude to Tuberculosis
Authors: J. G. Scadding
Journal: BMJ (1968)

<h3>Abstract</h3> <h3>Background</h3> Exploratory analysis of complex transcriptomic data presents multiple challenges. Many methods often rely on preexisting gene annotations, impeding identification and characterization of new transcripts. Even for a single cell type, comprehending the diversity of RNA species transcribed at each genomic region requires combining multiple datasets, each enriched for specific types of RNA. Currently, examining combinatorial patterns in these data requires time-consuming visual inspection using a genome browser. <h3>Method</h3> We developed a new segmentation and genome annotation (SAGA) method, SegRNA, that integrates data from multiple transcriptome profiling assays. SegRNA identifies recurring combinations of signals across multiple datasets measuring the abundance of transcribed RNAs. Using complementary techniques, SegRNA builds on the Segway SAGA framework by learning parameters from both the forward and reverse DNA strands. SegRNA’s unsupervised approach allows exploring patterns in these data without relying on pre-existing transcript models. <h3>Results</h3> We used SegRNA to generate the first unsupervised transcriptome annotation of the K562 chronic myeloid leukemia cell line, integrating multiple types of RNA data. Combining RNA-seq, CAGE, and PRO-seq experiments together captured a diverse population of RNAs throughout the genome. As expected, SegRNA annotated patterns associated with gene components such as promoters, exons, and introns. Additionally, we identified a pattern enriched for novel small RNAs transcribed within intergenic, intronic, and exonic regions. We applied SegRNA to FANTOM6 CAGE data characterizing 285 lncRNA knockdowns. Overall, SegRNA efficiently summarizes diverse multi-experiment data.
Migration and gout: the Tokelau Island migrant study.
Authors: I A Prior, T J Welby, T Ostbye, C E Salmond, Y M Stokes
Journal: BMJ (1987)

The prevalence and 14 year incidence of clinical gout and its precursors were investigated in the Polynesian population of Tokelauans living in the Pacific basin, non-migrant Tokelauans living in their isolated atoll homeland being compared with migrant Tokelauans living in urban New Zealand. The age standardised prevalence of gout in Tokelauan men in New Zealand was higher than that in non-migrant Tokelauan men, being 21.0 and 19.5/1000 subjects at the beginning of the study and 51.0 and 14.6/1000 at the end of study, respectively. Migrant men in New Zealand aged under 55 had higher mean serum uric acid concentrations than non-migrant men of the same age. The prevalence of gout was low in women in both environments. The age standardised relative risk of developing gout between 1968 and 1982 was 9.0 times higher in the migrant men than in the non-migrant men. Age, serum uric acid concentration, serum cholesterol concentration, and self reported alcohol consumption at entry to the study were the best set of predictors of gout in men. Preventive strategies to change body mass, diet, and patterns of alcohol use need to be developed in this population.
Spectrum of NAFLD and diagnostic implications of the proposed new normal range for serum ALT in obese women
Authors: Sachin S. Kunde, Audrey J. Lazenby, Ronald H. Clements, Gary A. Abrams
Journal: Hepatology (2005)

Abstract The upper limit of normal for ALT activity has been recommended to be lowered to ≤30 U/L in men and ≤19 U/L in women. These changes have been suggested to be diagnostically useful in subjects with nonalcoholic fatty liver disease (NAFLD). Our aim was to investigate the prevalence and spectrum of NAFLD with regard to the new ALT guidelines in 233 women with class II/III obesity. We compared our prior reference range for ALT (ULN ≤ 30 U/L in women) with the new standard. Our study demonstrates that only 86 patients (36.9%) would be classified as having normal ALT levels compared with 169 patients (72.5%) by the new and old standards, respectively. In patients with normal ALT activity (new vs. old standard), the prevalence of fatty liver (FL: 39.5% vs 40.2%), portal fibrosis, and steatosis (IPF: 37.2% vs. 33.7%) and nonalcoholic steatohepatitis (NASH: 23.3% vs. 26%) were similar. In comparison, newly defined patients with elevated ALT levels (&gt;19 U/L) demonstrated an increased prevalence of FL (36%) and IPF (11.6%) but a 23.8% decrease in the prevalence of NASH as compared with the old standard. The sensitivity and specificity for NASH were 42% and 80% (ALT &gt; 30 U/L) compared with 74% and 42% (ALT &gt; 19 U/L). In conclusion , a significant increase in the prevalence of FL and IPF is detected in subjects with elevated ALT levels with the application of the new standard. However, the diagnostic utility for ALT to identify NASH or IPF remains poor, and significant healthcare expenditures may be incurred if this standard is adopted. (Hepatology 2005.)
Somatic mutation of CDKN1B in small intestine neuroendocrine tumors
Authors: Joshua M Francis, Adam Kiezun, Alex H Ramos, Stefano Serra, Chandra Sekhar Pedamallu, Zhi Rong Qian, Michaela S Banck, Rahul Kanwar, Amit A Kulkarni, Anna Karpathakis, Veronica Manzo, Tanupriya Contractor, Juliet Philips, Elizabeth Nickerson, Nam Pho, Susanne M Hooshmand, Lauren K Brais, Michael S Lawrence, Trevor Pugh, Aaron McKenna, Andrey Sivachenko, Kristian Cibulskis, Scott L Carter, Akinyemi I Ojesina, Samuel Freeman, Robert T Jones, Douglas Voet, Gordon Saksena, Daniel Auclair, Robert Onofrio, Erica Shefler, Carrie Sougnez, Jonna Grimsby, Lisa Green, Niall Lennon, Tim Meyer, Martyn Caplin, Daniel C Chung, Andreas S Beutler, Shuji Ogino, Christina Thirlwell, Ramesh Shivdasani, Sylvia L Asa, Chris R Harris, Gad Getz, Matthew Kulke, Matthew Meyerson
Journal: Nature Genetics (2013)
Patterns and processes in communities of heirninth parasites
Authors: Wayne P. Sousa
Journal: Trends in Ecology & Evolution (1994)

What processes account for the structure and dynamics of helminth parasite assemblages within vertebrate and invertebrate hosts? Attempts to answer this question form the basis for the emerging subdiscipline of parasite community ecology. Negative interspecific interactions strongly affect the distribution and abundance of parasites in some systems, but only intermittently, if ever, in others. Empirical results provide only mixed support for recent theories that attempt to explain this variation.
Comparative study on the properties of acrylic bone cements prepared with either aliphatic or aromatic functionalized methacrylates
Authors: Jose M. Cervantes-Uc, Humberto Vázquez-Torres, Juan Valerio Cauich-Rodríguez, Blanca Vázquez-Lasa, Julio San Román del Barrio
Journal: Biomaterials (2004)
V/Q SCINTIGRAPHIC FINDINGS IN OBLITERATIVB BRONCHIOLITIS AFTER HEART-LUNG TRANSPLANTATION
Authors: I. R. HcDougall, M. R. Kramer, S. E. Marshall, A. S. Klonecke, J. J. I. ewiston, J. Theodore
Journal: Clinical Nuclear Medicine (1991)

HcDougall, I. R.; Kramer, M. R.; Marshall, S. E.; Klonecke, A. S.; ewiston, J. J. I.; Theodore, J. Author Information
Micronutrient supplementation in pregnancy in developing countries
Authors: G. Hiremath
Journal: BMJ (2008)

Micronutritional interventions clearly have a major role in improving womens health pregnancy birth outcomes and child survival. Future endeavours must focus on carefully designed nutritional research that could help elucidate the mechanisms by which micronutrients exert beneficial effects and increase our understanding of the interactions between micronutrients that influence their bioavailability. Prospective high quality community trials should look at the influence of maternal nutritional status on pregnancy and perinatal outcomes. They should also focus on identifying the optimal micronutritional approach (supplementation with single or multiple micronutrients) in representative populations and inform local policies. In due course the effectiveness of these approaches should be tested at the community level. Ultimately long term efforts should involve a multidimensional approach to bring about a global improvement in womens health precipitate social changes and bridge cultural gaps. (excerpt)
DIPHTHERIA OF THE PENIS
Authors: J. Fredric Prinzing
Journal: JAMA (1928)

The most frequent site of diphtheritic inflammation is the mucous membrane of the throat, larynx and nose. Diphtheria organisms have also been found in the ear, on the mucous membrane of the stomach, in the vulva, and on the conjunctiva and the skin. In view of these facts, the case reported here is not only unusual, but also important clinically. <h3>REPORT OF CASE</h3> A man, aged 28, married, seen, May 1, 1927, at 7 p. m., complained simply of feeling ill, the reason for such an indefinite complaint, as was discovered later, being that his brother-in-law was present at the first visit. He had been in this condition for two or three days, the onset having been gradual in character. On general examination, the temperature was found to be 104 F. and the pulse 126. The head, neck and chest were normal, as was also the abdomen
Malignant Melanoma
Authors: Herbert Fanger, Wesley F. Roberts
Journal: New England Journal of Medicine (1952)

ALTHOUGH there have been several important contributions to the literature dealing with the pathology and treatment of malignant melanoma,1 2 3 4 5 6 7 8 9 10 11 12 any addition to the general body of experience with these treacherous tumors is highly desirable. A total of 47 cases of malignant melanoma are in the files of the Tumor Clinic of the Rhode Island Hospital for the years 1932–1948. Of these 26 have been included in a study limited to primary lesions of the skin and mucous membrane. The remainder have been deleted because many were terminal cases when first seen or were recent cases, not enabling adequate follow-up.Table 1 lists . . .
Pyoderma Gangrenosum with Oral Involvement – Case Report and Review of the Literature
Authors: Geetha Paramkusam, Venkateswarlu Meduri, Naresh Gangeshetty
Journal: International Journal of Oral Science (2010)

Pyoderma gangrenosum (PG) is a rare, noninfectious neutrophilic dermatosis. Clinically, it begins with sterile pustules that rapidly progress into painful ulcers of variable depth and size with undermined violaceous borders. The diagnosis of PG is based on the history of an underlying disease, a typical clinical presentation, histopathology, and exclusion of other diseases. The peak incidence occurs between the ages of 20 to 50 years with women being more often affected than men. There have been very few reports of pyoderma gangrenosum with oral mucosal involvement. Oral lesions in previously reported cases have included ulcers of varying sizes from a few mm to several cm and have been reported to have been found on the tongue, soft and hard palate, buccal mucosa, and gingiva. Some of these oral lesions have been associated with ulcerative colitis, inflammatory bowel disease, and polycythemia rubra vera. A few cases were reported with biopsy findings, the histological picture being nonspecific, showing ulceration, and necrosis with inflammatory cell infiltrate. A peculiar case of pyoderma gangrenosum with an oral lesion is presented here, and the differential diagnosis is discussed.
Splenic Infarction Detected by Tc-99m RBC Scintigraphy
Authors: CHARLES W. SUTTER, NADER H. BEHESHTI, ROBERT C STADALNIK
Journal: Clinical Nuclear Medicine (1995)

A 53-year-old man with a history of gallstone pancreatitis and pancreatic pseudocyst was admitted with obstructive jaundice, abdominal pain, fever, and chills. Gastrointestinal bleeding developed, and a labeled red blood cell scan was obtained that demonstrated asymmetric tracer activity in the splenic bed. A lateral image revealed a large wedge-shaped defect in the midbody of the spleen with a smaller defect seen posteriorly. Computed tomography scan showed evidence of a pancreatic abscess and multiple splenic defects. At surgery, the abscess was drained and a splenectomy performed. Pathology revealed evidence of a large acute splenic infarct, as well as several small splenic infarcts.