tbuckley/cabot-search huggingface dataset:
New psychiatric inpatient unit for adolescents.
Authors: J. D. Haldane, D. McInnes
Journal: BMJ (1968)

The Department of Child and Family Psychiatry at Stratheden Hospital became a full-time service in 1960, providing the psychiatric services for children, adolescents, and their parents in the County of Fife (population 320,000).The outpatient facilities include clinics in general hospital and local authority premises.The first inpatient facility was the unit for children (12 places for boys and girls under 12 years of age) opened in January 1960.The unit for adolescents, described here and opened in April 1968, was the next stage.Later the children's unit will either be extended and modernized or be rebuilt, and proposals are being considered for the building near these two units of a unit for the admission of families. StaffingThe department staff establishment comprises two con- sultants, one senior registrar, two registrars, one senior clinical psychologist, and five senior social workers.The inpatient service staff comprises, in addition, one senior assistant chief male nurse, nursing and domestic staff (slightly less than 1: 1 ratio), three teachers (whose salaries are paid by the local education authority), and one occupational therapist.Four secretarial staff provide the clerical/secretarial services to the whole staff.All the department staff have responsibilities in both inpatient units and other staff are appointed to the inpatient service rather than exclusively to either of the inpatient units. Considerations in Planning GeneralTo facilitate the work of the staff we planned that the new unit be built near the existing children's unit, allowing for the possibility that the latter might be rebuilt on a new site.We could not discover any evidence to suggest that the close physical relationship of the two units would be to the dis- advantage of either children or adolescents.As the department staff had inadequate consulting-room and office accommodation, this was to be incorporated in the new building.(If eventually the children's unit is extended, the administration/consultation section may become the physical " link " between the two inpatient units.)Sufficient open space for recreation was required.Ease and rapidity of building and the capacity for possible extension at a later date were additional factors.
Treatment monitoring of topical ingenol mebutate in actinic keratoses with the combination of optical coherence tomography and reflectance confocal microscopy: a case series
Authors: T. Maier, D. Cekovic, T. Ruzicka, E.C. Sattler, C. Berking
Journal: British Journal of Dermatology (2014)

Journal Article Treatment monitoring of topical ingenol mebutate in actinic keratoses with the combination of optical coherence tomography and reflectance confocal microscopy: a case series Get access T. Maier, T. Maier Department of Dermatology and Allergology University Hospital of Munich Frauenlobstraße 9–11 D‐80337 Munich Germany Correspondence: Tanja Maier. E‐mail: Tanja.Maier@med.uni-muenchen.de Search for other works by this author on: Oxford Academic Google Scholar D. Cekovic, D. Cekovic Department of Dermatology and Allergology University Hospital of Munich Frauenlobstraße 9–11 D‐80337 Munich Germany Search for other works by this author on: Oxford Academic Google Scholar T. Ruzicka, T. Ruzicka Department of Dermatology and Allergology University Hospital of Munich Frauenlobstraße 9–11 D‐80337 Munich Germany Search for other works by this author on: Oxford Academic Google Scholar E.C. Sattler, E.C. Sattler Department of Dermatology and Allergology University Hospital of Munich Frauenlobstraße 9–11 D‐80337 Munich Germany Search for other works by this author on: Oxford Academic Google Scholar C. Berking C. Berking Department of Dermatology and Allergology University Hospital of Munich Frauenlobstraße 9–11 D‐80337 Munich Germany Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 3, 1 March 2015, Pages 816–818, https://doi.org/10.1111/bjd.13304 Published: 01 March 2015
ANATOMIC RESEARCHES ON YELLOW FEVER.
Authors: EDWIN KLEBS
Journal: JAMA (1898)

Yellow fever, a true American disease, originating in the West Indies, is a permanent menace to the United States. So long as unhygienic conditions persist in Cuba, supported by a state of, it seems, permanent revolution and destruction, the southern parts of this land will never enjoy the security so necessary for the development of a general happy state of the population. But it may be asked, Is the terror excited by such invasions and the rigorous quarantine executed in consequence of this feeling of the population really necessary? We have learned in the last years by a more intimate knowledge of the causes and the manner of infection, that the severest diseases lose most of their danger and cease to excite the population. Relying on the possibility of securing himself against the infection, man will no more relinquish his home in blind terror. I might refer to the "Go-not-away-Club"
Simultaneous inhibition of GSK3α and GSK3β using hairpin siRNA expression vectors
Authors: Jenn-Yah Yu, Jennifer Taylor, Stacy L DeRuiter, Anne B Vojtek, David L Turner
Journal: Molecular Therapy (2003)

Short interfering RNAs (siRNAs) can mediate sequence-specific inhibition of gene expression in mammalian cells. We and others have recently developed expression vector-based systems for synthesizing siRNAs or hairpin siRNAs in mammalian cells. Expression vector-based RNA interference (RNAi) effectively suppresses expression of target genes and is likely to be a powerful tool for analysis of gene function. Here we compare inhibition by vectors expressing hairpin siRNA designs either with different loop sequences connecting the two siRNA strands, or with duplex regions of different lengths. Our results suggest that lengthening the 19-nucleotide duplex region of a relatively ineffective hairpin siRNA can increase inhibition, but increasing the length of an effective 19-nt hairpin siRNA does not increase inhibition. We also demonstrate that hairpin siRNA vectors can be used to inhibit two target genes simultaneously. We have targeted glycogen synthase kinase-3α (GSK-3α) and GSK-3β, two related kinases involved in the regulation of a variety of cellular processes and also implicated in the pathogenesis of several human diseases. Inhibition of either GSK-3α or GSK-3β by transfection of hairpin siRNA vectors leads to elevated expression of the GSK-3 target β-catenin, whereas inhibition of both kinases further increases β-catenin expression. Our results suggest that vector-based siRNA inhibition may be useful for dissecting the functional roles of GSK-3α and GSK-3β in somatic cells. The ability to inhibit two or more genes simultaneously with hairpin siRNA expression vectors should facilitate studies of gene function in mammalian cells.
ATP-dependent canalicular bile ACID transport: Another piece of the puzzle
Authors: Daniel J. Smith
Journal: Hepatology (1992)

ABSTRPlCT The secretion of bile by the liver is primarily determined by the ability of the hepatocyte to transport bile acids into the bile canaliculus. A carrier–mediated process for the transport of taurocholate, the major bile acid in humans and rats, was previously demonstrated in canalicular membrane vesicles from rat liver. This process is driven by an outside–positive membrane potential that is, however, insufficient to explain the large bile acid concentration gradient between the hepatocyte and bile. In this study, we describe an ATP–dependent transport system for taurocholate in inside–out canalicular membrane vesicles from rat liver. The transport system is saturable, temperature–dependent, osmotically sensitive, specifically requires ATP, and does not function in sinusoidal membrane vesicles and right side–out canalicular membrane vesicles. Transport was inhibited by other bile acids but not by substrates for the previously demonstrated ATP–dependent canalicular transport systems for organic cations or nonbile acid organic anions. Defects in ATP–dependent canalicular transport of bile acids may contribute to reduced bile secretion (cholestasis) in various developmental, inheritable, and acquired disorders. Direct photoaffinity labeling of liver plasma membrane subfractions enriched in sinusoidal and canalicular membranes using [ 35 S]adenosine 5′– O –(thiotriphosphate) ([ 35 S]ATPγS) allows the identification of ATP–binding proteins in these domains. Comparative photoaffinity labeling with [ 35 S]ATPγS and with the photolabile bile salt derivative (7,7–azo–3α,12α–dihydroxy–5β–[3β–H]–cholan–24–oyl)–2′–aminethanesulfonate followed by immunoprecipitation with a monoclonal antibody (Be 9.2) revealed the identity of the ATP–binding and the bile salt–binding canalicular membrane glycoprotein with the apparent Mr of 110,000 (gp110). The isoelectric point of this glycoprotein was 3.7. Transport of bile salt was studied in vesicles enriched in canalicular and sinusoidal liver membranes. Incubation of canalicular membrane vesicles with [H] taurocholate in the presence of ATP resulted in an uptake of the bile salt into the vesicles which was sensitive to vanadate. ATP–dependent taurocholate transport was also observed in membrane vesicles from mutant rats deficient in the ATP–dependent transport of cysteinyl leukotrienes and related amphiphilic anions. Substrates of the P–glycoprotein (gp170), such as verapamil and doxorubicin, did not interfere with the ATP–dependent transport of taurocholate. Reconstitution of purified gp 110 into liposomes resulted in an ATP–dependent uptake of [H]taurocholate. These results demonstrate that gp110 functions as carrier in the ATP–dependent transport of bile salts from the hepatocyte into bile. This export carrier is distinct from hitherto characterized ATP–dependent transport systems.
Neurologic Manifestations of Vitamin B<sub>12</sub>Deficiency
Authors: Katalin Scherer
Journal: New England Journal of Medicine (2003)

A 56-year-old woman presented with a four-month history of progressive cognitive decline, weakness, incoordination, and gait disturbance. She had a score of 12 of 28 on the Mini–Mental State Examination, moderate weakness, and severe ataxia; reflexes, vibratory sensation, and the sense of position were absent throughout her arms and legs. T2-weighted magnetic resonance imaging (MRI) of the brain demonstrated extensive areas of high-intensity signal in the periventricular white matter (Panel A, arrow). MRI of the spine showed a hyperintense signal along the posterior columns in all segments, including the lower portion of the cervical cord (Panel B, arrow). . . .
Best Practices in Medical Management
Authors: John E. Billi, Jeanne M. Kin
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes3 August 1999Best Practices in Medical ManagementJohn E. Billi, MD and Jeanne M. Kin, MHA, JDJohn E. Billi, MDUniversity of Michigan Medical School, Ann Arbor, Michigan. (Billi, Kin)Search for more papers by this author and Jeanne M. Kin, MHA, JDUniversity of Michigan Medical School, Ann Arbor, Michigan. (Billi, Kin)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-3-199908030-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Kongstvedt PR, Plocher DW; eds. 675 pages. Gaithersburg, MD: Aspen; 1998.$79.00. ISBN 0834210908. Order phone 800-234-1660.Field of medicine: Medical management, health policy, and health management.Format: Hardcover book.Audience: Health care managers, including managed care or physician organization executives; physicians, nurse practitioners, and physician assistants practicing in managed care settings; physician office staff; case managers, utilization review managers, and quality managers; employee benefit officers; health care consultants; health policymakers; health management and policy students; medical students; and residents.Purpose: To provide a comprehensive overview of the medical management activities that surround provision of care to members of a managed ... Author, Article, and Disclosure InformationAffiliations: University of Michigan Medical School, Ann Arbor, Michigan. (Billi, Kin) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 August 1999Volume 131, Issue 3Page: 236KeywordsHealth careHealth care qualityHealth care utilizationHealth information technologyInpatientsNursesPerformance measuresPrevention, policy, and public healthRisk assessmentsSystemic diseases ePublished: 15 August 2000 Issue Published: 3 August 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
New Program to SCOPE Out Resistant Organisms
Authors: Charles Marwick
Journal: JAMA (1995)

SEVERAL INSTITUTIONS have volunteered to become part of a new effort to keep antibiotic-resistant organisms from becoming a 20th-century version of long-past plagues. Starting January 1, a program called Surveillance and Control of Pathogens of Epidemiologic Importance (SCOPE) went into effect. This national network is designed to track resistant pathogens and be an early-warning system for the health care community. It was set up by the University of Iowa College of Medicine, Iowa City, in collaboration with Lederle Laboratories, Wayne, NJ. The objective is to help hospitals control resistant infections by identifying them early. SCOPE is the largest nongovernmental surveillance program and the first combined effort of industry, academe, and hospitals to track microbial resistance. Data collected at 48 sentinel hospitals will be used for nationwide projections and identification of newly resistant strains. A system such as this is badly needed, says Richard P. Wenzel, MD, director of general medicine
ANTITOXIN AND INTUBATION WITH A REPORT OF 100 OPERATIONS.
Authors: BURT RUSSELL SHURLY
Journal: JAMA (1900)

The results of progress in scientific therapeutics can be most thoroughly demonstrated in the treatment of laryngeal diphtheria. The uncertain pathology of this disease has assumed a clear and definite position under the light of modern bacteriologic research. Arguments on the nature of the causative microbe are past, and the claims of the Klebs-Loeffler bacillus are established. The question has been decided, and the presence of the Klebs-Loeffler bacillus is demonstrated in primary pseudomembranous laryngitis almost without exception. A careful investigation of the management of diphtheria patients, and a study of the development of new cases from day to day leads to the conclusion that the great mortality can be reduced one-half by early treatment. The great importance of more care in recognizing the causes and enforcing the means of preventing diphtheria are obvious. The causes of the rise and fall in the number of cases in our city require
Effects of Community-Wide Vaccination with PCV-7 on Pneumococcal Nasopharyngeal Carriage in The Gambia: A Cluster-Randomized Trial
Authors: Anna Roca, Philip C. Hill, John Townend, Uzo Egere, Martin Antonio, Abdoulie Bojang, Abiodun Akisanya, Teresa Litchfield, David E. Nsekpong, Claire Oluwalana, Stephen R. C. Howie, Brian Greenwood, Richard A. Adegbola
Journal: PLoS Medicine (2011)

Background Introduction of pneumococcal conjugate vaccines (PCVs) of limited valency is justified in Africa by the high burden of pneumococcal disease. Long-term beneficial effects of PCVs may be countered by serotype replacement. We aimed to determine the impact of PCV-7 vaccination on pneumococcal carriage in rural Gambia. Methods and Findings A cluster-randomized (by village) trial of the impact of PCV-7 on pneumococcal nasopharyngeal carriage was conducted in 21 Gambian villages between December 2003 to June 2008 (5,441 inhabitants in 2006). Analysis was complemented with data obtained before vaccination. Because efficacy of PCV-9 in young Gambian children had been shown, it was considered unethical not to give PCV-7 to young children in all of the study villages. PCV-7 was given to children below 30 mo of age and to those born during the trial in all study villages. Villages were randomized (older children and adults) to receive one dose of PCV-7 (11 vaccinated villages) or meningococcal serogroup C conjugate vaccine (10 control villages). Cross-sectional surveys (CSSs) to collect nasopharyngeal swabs were conducted before vaccination (2,094 samples in the baseline CSS), and 4–6, 12, and 22 mo after vaccination (1,168, 1,210, and 446 samples in CSS-1, -2, and -3, respectively). A time trend analysis showed a marked fall in the prevalence of vaccine-type pneumococcal carriage in all age groups following vaccination (from 23.7% and 26.8% in the baseline CSS to 7.1% and 8.5% in CSS-1, in vaccinated and control villages, respectively). The prevalence of vaccine-type pneumococcal carriage was lower in vaccinated than in control villages among older children (5 y to <15 y of age) and adults (≥15 y of age) at CSS-2 (odds ratio [OR] = 0.15 [95% CI 0.04–0.57] and OR = 0.32 [95% CI 0.10–0.98], respectively) and at CSS-3 (OR = 0.37 [95% CI 0.15–0.90] for older children, and 0% versus 7.6% for adults in vaccinated and control villages, respectively). Differences in the prevalence of non-vaccine-type pneumococcal carriage between vaccinated and control villages were small. Conclusions Vaccination of Gambian children reduced vaccine-type pneumococcal carriage across all age groups, indicating a “herd effect” in non-vaccinated older children and adults. No significant serotype replacement was detected. Please see later in the article for the Editors' Summary
Significance of right atrial function during right sided inotropic stimulation of pig hearts in situ
Authors: O. A VENGEN, O. ELLINGSEN, K. LANDE, A. ILEBEKK
Journal: Cardiovascular Research (1988)

Cardiac adjustments to inotropic stimulation of the right side of the heart were examined in anaesthetised, open chest pigs by calcium chloride infusion (80 mumol.min-1) into the right coronary artery. At stable haemodynamic conditions and at constant heart rate, right ventricular (RV) pre-ejection segment length increased by 4.6 (2.7-7.2) % (median, 95 % confidence interval) (p less than 0.01), RV end diastolic pressure rose from 5.3 (3.4-7.7) to 6.0 (3.6-8.8) mm Hg (p less than 0.05), and stroke volume rose by 6.8 (4.2-10.8) % (p less than 0.001). When the effect of right atrial contraction on RV filling was excluded by simultaneous pacing of atria and ventricles, the RV pre-ejection segment length no longer increased, and stroke volume rose by only 3.5 (0.1-9.5) % (p less than 0.05) during right side inotropic stimulation. Right atrial inotropic stimulation improves right ventricular filling, and may cause redistribution of blood from the systemic to the pulmonary circulation. This redistribution would raise the pulmonary vascular pressures, and thereby also improve left ventricular filling. The improved right ventricular filling partly accounts for the rise in RV output.
Should Epileptics Scuba Dive?
Authors: J. Thomas Millington
Journal: JAMA (1985)

<h3>To the Editor.—</h3> The Professional Advisory Board of the Epilepsy Foundation of America<sup>1</sup>responded to an inquiry<sup>2</sup>about scuba diving for persons with epilepsy in a recent issue. The Advisory Board of the Epilepsy Foundation of America was of the opinion that the decision as to whether a patient may scuba dive should be made by the individual with epilepsy and not by the examining physician. They also noted that, although there is an increased risk of accident or death in scuba divers, this should be an individual decision. Although one would certainly agree with their concept that the decision whether or not to participate in sports or other activities in life that are hazardous ideally should be an individual one, the examining physician is left with the dilemma as to whether, verbally or in writing, to permit or restrict diving. The patient who suffers from a seizure
Publicly available performance tables do not make surgeons avoid high risk cases
Authors: Susan Mayor
Journal: BMJ (2007)

The government has admitted that it will have to wait years before it discovers whether there are real productivity gains from the new consultants' contract.NHS leaders also told the House of Commons Committee of Public Accounts last week that lessons had been learnt from mistakes made when the contract was introduced, such as not piloting it before implementation.They were giving evidence as part of the committee's inquiry into the consultants' contract.The session was prompted by the publication earlier this month of a report from the government's
Director of a Small Mental Health Clinic
Authors: Ralph Crawshaw
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transforming Growth Factor β-Mediated Suppression of Antitumor T Cells Requires FoxP1 Transcription Factor Expression
Authors: Tom L. Stephen, Melanie R. Rutkowski, Michael J. Allegrezza, Alfredo Perales-Puchalt, Amelia J. Tesone, Nikolaos Svoronos, Jenny M. Nguyen, Fahmida Sarmin, Mark E. Borowsky, Julia Tchou, Jose R. Conejo-Garcia
Journal: Immunity (2014)
Pre - proparathyroid hormone identified by cell - free translation of messenger RNA from hyperplastic human parathyroid tissue.
Authors: J F Habener, B Kemper, J T Potts, A Rich
Journal: Journal of Clinical Investigation (1975)

An 8-15S fraction of RNA isolated from hyperplastic human parathyroid tissue (primary chief-cell hyperplasia) and translated in a cell-free extract of wheat germ directs the synthesis of a protein that shares antigenic determinants and tryptic peptides with parathyroid hormone and its previously recognized immediated precursor, proparathyroid hormone. In addition, the protein contains tryptic peptides not found in proparathyroid hormone and migrates more slowly than does proparathyroid hormone on both urea-acid and urea-sodium dodecyl sulfate polyacrylamide gels, indicating that it is more acidic and larger than proparathyroid hormone. Sequential Edman degradation of the cell-free protein, radiolabeled with [35S]methionine, for 25 cycles released [35S]methionine at cycles 1, 7, 11, and 14, indicating that the NH2-terminal peptide sequence of the protein differs from that of both proparathyroid hormone and parathyroid hormone. We propose that this protein is an early biosynthetic precursor of human parathyroid hormone, pre-proparathyroid hormone, analogous to that identified recently by in vitro translation of bovine parathyroid mRNA.