Hypertrophic Osteoarthropathy Associated with Cyanotic Congenital Heart Disease
Authors: GEORGE E. MCLAUGHLIN
Journal: Annals of Internal Medicine (1967)

Case Studies1 September 1967Hypertrophic Osteoarthropathy Associated with Cyanotic Congenital Heart DiseaseA Report of Two CasesGEORGE E. MCLAUGHLIN, M.D., DANIEL J. MCCARTY JR., M.D., F.A.C.P., D. F. DOWNING, M.D., F.A.C.P.GEORGE E. MCLAUGHLIN, M.D., DANIEL J. MCCARTY JR., M.D., F.A.C.P., D. F. DOWNING, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-3-579 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHypertrophic osteoarthropathy associated with cyanotic congenital heart disease is a rare, poorly understood, but well-documented entity. Trever (1) reported 2 cases in 1958 and cited an incidence of 0.1% in a series of 3,000 cases of cyanotic heart disease. The clinical picture includes periosteal new bone formation, usually localized to the distal ends of the long bones, and overlying soft tissue neovascularization manifested by warmth, tenderness, and edema. When hypertrophic osteoarthropathy is associated with cyanotic congenital heart disease, clubbing of the digits has been a constant finding. The presence of synovitis, noted at necropsy in five of six cases of...References1. TREVER RW: Hypertrophic pulmonary osteoarthropathy in association with congenital cyanotic heart disease: report of two cases. Ann. Intern. Med. 48: 660, 1958. LinkGoogle Scholar2. GALLBENNETTBAUER EAGAW: Generalized hypertrophic osteoarthropathy. A pathologic study of seven cases. Amer. J. Path. 27: 349, 1951. MedlineGoogle Scholar3. HOLLINGBRODEY HERS: Pulmonary hypertrophic osteoarthropathy. JAMA 178: 977, 1961. CrossrefMedlineGoogle Scholar4. GINSBURG J: Hypertrophic pulmonary osteoarthropathy. Postgrad. Med. J. 39: 639, 1963. 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ROBINSONKAHNSYED RDAHSA: Hypertrophic osteoarthropathy in congenital heart disease. J. Pakistan Med. Ass. 15: 246, 1965. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaFrom the Rheumatology Section, Department of Medicine, Hahnemann Medical College and Hospital, Philadelphia, Pa.This study was supported in part by grant AM5201-05, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md.Dr. McLaughlin is a Trainee in Rheumatology, Hahnemann Medical College and Hospital, under grant AM5201-05. Dr. McCarty is a Markle Scholar in Academic Medicine.Requests for reprints should be addressed to Daniel J. McCarty, Jr., M.D., Hahnemann Hospital, 230 N. Broad St., Philadelphia, Pa. 19102. 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Simultaneous occurrence in association with diffuse interstitial fibrosisHypertrophic osteoarthropathy associated with Fallot's tetralogy--a case reportHypertrophic Osteoarthropathy in Cyanotic Congenital Heart DiseaseNineteenth rheumatism review. Part-IIIHypertrophic osteoarthropathy with arthritis and synovial calcification in a patient with alcoholic cirrhosis 1 September 1967Volume 67, Issue 3_Part_1Page: 579-587KeywordsBoneCardiovascular therapyCongenital heart diseaseEdemaHospital medicineLongitudinal studiesMetabolic disordersNeovascularizationRheumatologySoft tissues Issue Published: 1 September 1967 PDF downloadLoading ...