tbuckley/cabot-search huggingface dataset:
Prenatal DDT Exposure in Relation to Anthropometric and Pubertal Measures in Adolescent Males
Authors: Beth C. Gladen, Mark A. Klebanoff, Mary L. Hediger, Solomon H. Katz, Dana B. Barr, Mark D. Davis, Matthew P. Longnecker
Journal: Environmental Health Perspectives (2004)

DDT (dichlorodiphenyltrichloroethane), a pesticide once used widely in agriculture and now limited to public health use, remains a controversial chemical because of a combination of benefits and risks. DDT or its breakdown products are ubiquitous in the environment and in humans. Compounds in the DDT family have endocrine actions and have been associated with reproductive toxicity. A previous study reported associations between prenatal exposure to p,p -DDE [1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene] and increased height and weight in adolescent boys. We examined a group with higher exposures to see whether similar associations would occur. Our study group was 304 males born in Philadelphia in the early 1960s who had participated in a previous study. Anthropometric and pubertal measures from one to six visits during their adolescent years were available, as were stored maternal serum samples from pregnancy. We measured p,p -DDE, p,p -DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane], and o,p -DDT [1,1,1-trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)-ethane] in the maternal serum. Outcomes examined in the boys were height, ratio of sitting height to height, body mass index, triceps skinfold thickness, ratio of subscapular to the sum of triceps and subscapular skinfold thicknesses, skeletal age, serum testosterone, and serum dehydroepiandrosterone sulfate. No associations between prenatal exposure to any of the DDT compounds and any outcome measure were seen.
Hemolysis from Hot Dialysate
Authors: D. R. FORSDYKE
Journal: Annals of Internal Medicine (1976)

Comments and Corrections1 April 1976Hemolysis from Hot DialysateD. R. FORSDYKE, PH.D. (Cantab.)D. R. FORSDYKE, PH.D. (Cantab.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-4-490_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Doctor Berkes and colleagues (Ann Intern Med 83:363-364, 1975) report the delayed onset of protracted hemolysis after the extracorporeal overheating of blood to 50 °C during hemodialysis. The patient's hemoglobin and hematocrit levels failed to rise after transfusion of 2 units of packed erythrocytes on the third day after the accident. The authors suggest that thermal injury to erythrocytes is the reason for the hemolysis.An alternative hypothesis is that there may have been thermal injury to plasma proteins, such as complement components. These altered proteins might trigger delayed hemolysis both of the patient's erythrocytes and of...Reference1. FORSDYKE D: Serum factors affecting the incorporation of 3H-thymidine by lymphocytes stimulated by antigen. II. Evidence for a role of complement from studies with heated serum. Immunology 25:597-612, 1973 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: D. R. FORSDYKE, PH.D. (Cantab.)Affiliations: Department of Biochemistry Queen's University Kingston, Ontario, Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnemia associated with changes in iron and iron-59 utilization in copper deficient rats fed high levels of dietary ascorbic acid and ironThe Medical Treatment of Autistic PeopleInteraction of Dietary Carbohydrate, Ascorbic Acid and Copper with the Development of Copper Deficiency in RatsToxic Effects of Water-Soluble Vitamins 1 April 1976Volume 84, Issue 4 Page: 490-490 Keywords Blood Hematocrit Hemoglobin Plasma proteins Proteins ePublished: 1 December 2008 Issue Published: 1 April 1976 PDF downloadLoading ...
Using Systematic Reviews in Clinical Education
Authors: Robert G. Badgett
Journal: Annals of Internal Medicine (1997)

Traditional educational methods change clinical practice only with considerable effort and difficulty. In particular, the teaching of critical appraisal in the setting of journal clubs does not increase the amount of medical research read by trainees. Experiential learning theory, corroborated by the success of problem-based learning, encourages us to link learning to the numerous medical questions that physicians generate while providing patient care. Systematic reviews can link these questions with the results of research that would otherwise be difficult to locate, read, and appraise. Systematic reviews are a uniquely powerful mechanism for teaching, and they offer teachers a new opportunity to model rational and effective use of information. Systematic reviews should be made available at clinical sites for use during "teachable moments." Resistance to the use of systematic reviews can be reduced by using existing journal clubs to teach about the strengths and limitations of these reviews. The point that systematic reviews are meant to assist, not replace, clinical decision making deserves emphasis in such teaching.
Abstract 5487: Inhibitory effect of soluble EP2 receptor on ovarian tumor growth in nude mice and usefulness of TMPRSS4 as a molecular target for synergistic efficacy.
Authors: Tetsuyuki Takahashi, Hisanori Uehara, Keisuke Izumi
Journal: Cancer Research (2013)

Abstract Prostaglandin E2 (PGE2) plays an important role in cancer cell growth, progression, and metastasis and exerts its effects by binding to E-prostanoid receptor (EP). In the previous study, we showed that soluble fragment of EP2 receptor containing the second extracellular region (FuEP2/Ex2) has neutralizing activity to PGE2 and inhibits the growth of prostate and endometrial cancer cells. Here, we established a stable transfectant expressing FuEP2/Ex2 from human ovarian cancer SKOV/ip cells (SKOV/ip-FuEP2/Ex2) and SKOV/ip-FuEP2/Ex2 and vector-control cells were injected into nude mice intraperitoneally. Tumor weight and ascites volume in SKOV/ip-FuEP2/Ex2-injected mice decreased significantly compared to control cell-injected mice. Furthermore, microvessel density and numbers of M2-poralized macrophage in tumor lesion were significantly decreased in SKOV/ip-FuEP2/Ex2-injected mice. By using RNAs from tumor lesion in each group, the cDNA microarray analysis was also conducted. Six of upregulated genes and eight of downregulated genes in SKOV/ip-FuEP2/Ex2-derived tumor were identified. In upregulated genes, MMP-7, TMPRSS4, and CYP1B1, which is involved in cancer progression and metastasis, were included. Treatment with AEBSF, an inhibitor of TMPRSS4, or siRNA for TMPRSS4 further reduced cell growth of SKOV/ip-FuEP2/Ex2 cells in vitro and in vivo. Our results suggest that FuEP2/Ex2 has a suppressive effect in peritoneal metastasis model of ovarian cancer and that MMP-7, TMPRSS4, and CYP1B1 may act as a survival factor under the condition in which EP-mediated signaling are inhibited. Moreover, targeting of TMPRSS4 may enhance the inhibitory effect of FuEP2/Ex2 on ovarian cancer metastasis. Citation Format: Tetsuyuki Takahashi, Hisanori Uehara, Keisuke Izumi. Inhibitory effect of soluble EP2 receptor on ovarian tumor growth in nude mice and usefulness of TMPRSS4 as a molecular target for synergistic efficacy. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5487. doi:10.1158/1538-7445.AM2013-5487
Are Evening Surgeries Necessary?
Authors: H. Maxwell
Journal: BMJ (1964)

of facilities for routine screening of healthy women by cervical cytology at regular inter- vals.This matter vitally concerns clinical pathologists, and in most departments of clinical pathology there is already a service in exfoliative cytology for patients referred from many specialties, of which gynaecology is one."It is the opinion of the Council that any service in cervical cytology for healthy women should be regarded as preventive medicine and should be organized in collaboration with the hospital laboratory service, with which it should have the closest integration.The Council believe that cytological examinations and the training of technicians for this work must be in the hands of consultant pathologists.They believe it to be necessary to stress once more that a large proportion of hospital laboratories are already short of staff and accommodation, and it is clear that the implementation of the recommendations now being made about exfoliative cytology can only make matters worse.The appointment of extra staff and the provision of increased accommodation in hospital laboratories, which were already necessary, may now be expected to become even more urgent requirements."The Council wish to place these views on record, for they believe it to be vitally impor-
Delayed Childbearing and the Outcome of Pregnancy
Authors: Gertrud S. Berkowitz, Mary Louise Skovron, Robert H. Lapinski, Richard L. Berkowitz
Journal: New England Journal of Medicine (1990)

Whether women who delay childbearing are at increased risk for adverse outcomes of pregnancy is of concern because of the growing proportion of first births to older women. We assessed the effect of advancing maternal age on the outcome of pregnancy in first births in a hospital-based cohort study of 3917 private patients who were 20 years of age or older with a singleton gestation.
Population aging and the economic role of the elderly: Bonanza or burden?
Authors: Ronald D. Lee
Journal: Behavioral and Brain Sciences (2010)

Abstract As societies industrialize, the age profile of consumption tilts strongly toward the elderly, while elder labor supply drops. Low fertility and long life lead to population aging. For millennia, material resources have, on net, flowed downward from older to younger within populations, but now in many rich societies net flows have reversed and go upwards from young to old.
Reduced Fracture of the Forearm in a Child
Authors: Otto Aufranc
Journal: JAMA (1965)

Dr. Kirby vonKessler: Shortly after finishing a large picnic lunch, an 8-year-old boy fell from a fence and injured his left wrist. One hour later he arrived at the emergency ward of the Massachusetts General Hospital. Motion and sensation in his hand were normal in spite of an obvious deformity of the distal forearm. The radial pulse was easily palpable. The skin over the deformity was intact. X-ray films showed fractures of the distal third of both the radius and ulna (Fig 1) with posterior and lateral displacement of the distal fracture fragments. There was approximately 1 cm of overriding of the fracture fragments.  Dr. Aufranc: Dr. Arthur Pappas will discuss this fracture of both bones of the forearm in a child.  Dr. Arthur Pappas: In the overall evaluation of a displaced fracture, there are three important factors to consider: the patient's age and cooperation, the anatomical location of the
Anteroposterior radiography in cervical pain of non-traumatic origin.
Authors: M. Lloyd, J. Annis, P. Renton
Journal: BMJ (1989)

haematoma as incidental.There was no computed tomogram before treatment, the aetiology of the haematoma was not discussed, and results of examination of the cerebrospinal fluid were not given.In addition, the second reference is in supplement 1 of Cancer 7reatment Reports 1981 and not in the main journal.Rather than postulate a second, previously un- reported cause of this patient's neurological con- dition it would be simpler to follow Occam's razor and explain that which is obvious.The intracerebral haematoma may have resulted from hypertension, aneurysm, or haemorrhage into a deposit, in which case the administration of metho- trexate would then probably be incidental.
Safety agency makes better use of anticoagulants its top priority
Authors: Lynn Eaton
Journal: BMJ (2007)

s health secretary, has said that some Muslim GPs may be divulging details of the sexual health of female Muslim patients to family members.Her comments drew an angry response from Muslim GPs, who said that her claims were based only on anecdotal evidence.However, Mrs Hewitt, who represents a constituency in Leicester with a large ethnic minority community, said, "I have had Muslim women give me chapter and verse on very distressing breaches of confidentiality by Muslim GPs."Some women patients in some Muslim communities are feeling they can't trust their own GP, who is from the same community and knows their extended family."If they go for particular situations, such as a sexual health problem or domestic violence, they fear they will share that information with other members of the family or community."Mrs Hewitt made her comments in an interview with the magazine for GPs Pulse (29 Mar, p 2).Vijoy Singh, chairman of the Leicestershire and Rutland local medical committee, which covers Ms Hewitt's constituency, said, "No GP would break confidentiality, because if they break it they are liable to be sued.She's out of touch."Mrs Hewitt cited a report published in November last year by the Muslim Women's Network, which was based on conversations with Muslim women throughout the country, as further evidence of her concerns.The report, She Who Disputes (www.thewnc.org.uk/pubs/shewhodisputesnov06.pdf),noted: "Health services were criticised for being insensitive and there was repeated concern that GPs from within the community could not be trusted to maintain patient confidentiality." Hewitt says some Muslim GPs breach confidentialityUK NEWS Safety agency prioritises better use of anticoagulants, p714 World NEWS drugs are as goo�� as ���� in stable coronary artery ��isease, stu��y s�o�s, p71� drugs are as goo�� as ���� in stable coronary artery ��isease, stu��y s�o�s, p71� , p71� bmj.com o�for�� ra��cliffe �ospitals tol�� to impro�e team�or� o�for�� ra��cliffe �ospitals tol�� to impro�e team�or�
Role of Prostanoid DP Receptor Variants in Susceptibility to Asthma
Authors: Tsuyoshi Oguma, Lyle J. Palmer, Esra Birben, Larry A. Sonna, Koichiro Asano, Craig M. Lilly
Journal: New England Journal of Medicine (2004)

Previous genetic studies have associated the region of the human genome (14q22.1) containing the gene for the prostanoid DP receptor (PTGDR) with asthma. A study of a mouse model suggests that the receptor is required for the expression of the asthma phenotype. Our associations of asthma with functional genetic variants of PTGDR link these observations.We identified and evaluated combinations of genetic variants that influence PTGDR transcription for disease association in case-control studies of 518 white patients with asthma and 175 white controls and 80 black patients with asthma and 45 black controls.We identified four novel and two previously reported single-nucleotide polymorphisms (SNPs) in PTGDR and its vicinity. These define four common three-SNP haplotypes, which vary in their ability to support transcription of PTGDR and have distinct DNA-binding-protein affinity profiles. Individual PTGDR SNPs were significantly associated with asthma in both populations. Specific PTGDR haplotypes were significantly associated with a diagnosis of asthma in a large case-control study of whites (P=0.002); we confirmed these findings in a second population of blacks (P=0.01). Multivariate analysis of the haplotype combinations (diplotypes) demonstrated that both whites (odds ratio, 0.55; 95 percent confidence interval, 0.38 to 0.80; P=0.002) and blacks (odds ratio, 0.32; 95 percent confidence interval, 0.12 to 0.89; P=0.03) who had at least one copy of the haplotype with a low transcriptional efficiency had a lower risk of asthma than subjects with no copies of the haplotype.Our functional and genetic findings identify PTGDR as an asthma-susceptibility gene.
Pediatric Hospital Medicine and Education
Authors: Jennifer Maniscalco, Erin Stucky Fisher
Journal: JAMA Pediatrics (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Adrenaline, bronchoconstriction, and asthma.
Authors: A Morice, P Sever, P Ind
Journal: BMJ (1986)

Patients, methods, and resultsWe studied six patients with acute intermittent porphyria and four with variegate porphyria in remission to investigate the biochemical effects of haem arginate.We also treated nine acute attacks in four patients with acute intermittent porphyria.One of them had paresis, while the others had only abdominal and other gastrointestinal symptoms.Haem arginate was prepared from out of date human red cells in the laboratories of Medica Pharmaceutical Company Ltd, Helsinki, Finland.In 10 ml ampoules (haem 25 mg/ml) the preparation (Normosang), which is sterile and
1121-55 The presence of side branches impacts periprocedural enzyme elevation and clinical outcome in patients undergoing brachytherapy for in-stent restenosis
Authors: Pramod K Kuchulakanti, Seung-Woon Rha, Andrew E Ajani, Natalie Gevorkian, Ellen Pinnow, Rebecca Torguson, Augusto Pichard, Lowell F Satler, Kenneth Kent, Joseph Lindsay, Ron Waksman
Journal: Journal of the American College of Cardiology (2004)
THE APPLICATION OF THE JAPANESE CHRONIC TOTAL OCCLUSION (J–CTO) SCORE TO TAILOR APPROACHES AND PREDICT SUCCESS IN CHRONIC TOTAL OCCLUSION PERCUTANEOUS CORONARY INTERVENTIONS (CTO PCI)
Authors: Shantu S. Bundhoo, William Hui, Neil Brass, Benjamin Tyrrell, Po Cheung, Raymond Leung
Journal: Journal of the American College of Cardiology (2013)
P210Study of silent myocardial ischemia in type 2 diabetic males: upper egypt experience
Authors: A M Kassem, YHIA Kishk, ALI Hassan, MHAMED Abdelwahab
Journal: Cardiovascular Research (2014)

Purpose: Accelerated atherosclerosis is one of the most common complications of diabetes mellitus. A crucial aspect of coronary artery disease in this situation is its silent nature. Aim of the work: To detect the prevalence of silent myocardial ischemia (SMI) in type 2 diabetic males in Upper Egypt and to select diabetic males who should be screened for (SMI). Methods: The study includes 100 type 2 diabetic males with negative history of angina and 30 healthy subjects. Blood glucose , lipid profile, (HbA1c), microalbuminurea, and C-reactive protein were done. Non invasive tests (NITs) including ECG, echocardiography, treadmill exercise ECG, myocardial perfusion imaging were done for all participants and patients positive for one or more NITs were subjected for coronary angiography. Results: Twenty nine patients (29%) were positive for one or more NITs compared to only one case (3.3%) in the control group. After the results of coronary angiography, 20 patients were positive for significant coronary artery stenosis in patient group while it was refused to be done in the control group. There were significantly higher levels of microalbuminurea, C-reactive proteinand serum lipids in the patient group. Patient group was subdivided into two subgroups according to the results of coronary angiography, 20 positive for SMI (positive for coronary angiography) and 80 negative for SMI (negative for coronary angiography). Smoking, hypertension, obesity, hyperlipidemia, and family history of IHD were significantly higher in the diabetic subgroup positive for SMI compared to those negative for SMI.Chronic diabetic complications were more prevalent in patients positive for SMI than in those negative for SMI. Most of the patients positive for SMI had have DM for than 5 years duration. Resting ECG and resting Echo detected only 6 and 11 cases, respectively, of the 20 positive cases in group positive for SMI compared to treadmill exercise ECG and myocardial perfusion imaging that detected 16 and 18 cases respectively, Conclusion: Type 2 diabetic male patients should be screened for detection of SMI when age above 50 years, diabetes duration is more than 5 years ,presence of two or more cardiac risk factors and/or patients with one or more of chronic diabetic complications. CRP, is an important parameter for selection of type 2 diabetic male patients who should be screened for SMI. Treadmill exercise ECG and myocardial perfusion imaging are reliable tests for screening of SMI in type 2 diabetic males in our locality.
Association of Hostility With Coronary Artery Calcification in Young Adults
Authors: Carlos Iribarren, Stephen Sidney, Diane E. Bild, Kiang Liu, Jerome H. Markovitz, Jeffrey M. Roseman, Karen Matthews
Journal: JAMA (2000)

Context Psychosocial factors, including personality and character traits, may play a role in the development and expression of coronary artery disease.Objective To evaluate whether hostility, a previously reported predictor of clinical coronary artery disease, is associated with coronary calcification, which is a marker of subclinical atherosclerosis.Design Prospective cohort study. Setting and ParticipantsVolunteer subsample from Chicago, Ill, and Oakland, Calif, consisting of 374 white and black men and women, aged 18 to 30 years at baseline, who participated in the Coronary Artery Risk Development in Young Adults (CARDIA) study.Cook-Medley hostility assessment data were collected at baseline from 1985 to 1986 and at year 5 examinations from 1990 to 1992.After the 10-year examinations in the 1995-1996 year, electron-beam computed tomographic scans were performed.Main Outcome Measures Presence of any detectable coronary artery calcification (coronary calcium score Ͼ0), and coronary artery calcium scores of 20 or higher. ResultsIn logistic regression analysis adjusting for age, sex, race, and field center comparing those with hostility scores above and below the median of the distribution of the present sample, the odds ratio of having any coronary calcification was 2.57 (95% confidence interval, 1.31-5.22),and the odds ratio of having a calcium score of 20 or higher was 9.56 (95% confidence interval, 2.29-65.9)for calcium scores of 20 or higher.The associations with any coronary artery calcification persisted after adjusting for demographic, lifestyle, and physiological variables.Results using a cynical distrust subscale were somewhat weaker than for those using the global hostility score.Power was inadequate to perform sex-or race-specific analyses. ConclusionThese results suggest that a high hostility level may predispose young adults to coronary artery calcification.
Controlled Trial of Plasma Exchange and Leukapheresis in Polymyositis and Dermatomyositis
Authors: Frederick W. Miller, Susan F. Leitman, Mary E. Cronin, Jeanne E. Hicks, Richard L. Leff, Robert Wesley, David D. Fraser, Marinos Dalakas, Paul H. Plotz
Journal: New England Journal of Medicine (1992)

The therapeutic options for patients with polymyositis or dermatomyositis that is resistant to corticosteroids are limited, unproved, and often toxic. Uncontrolled trials concluded that both plasma exchange and leukapheresis are beneficial, but despite the considerable use of these approaches, proof of their efficacy is lacking.