tbuckley/cabot-search huggingface dataset:
A Study of the Venous Pulse in Tricuspid Valve Disease
Authors: ADDISON L. MESSER, JOHN WILLIS HURST, MAURICE B. RAPPAPORT, HOWARD B. SPRAGUE
Journal: Circulation (1950)

Diagnosis of lesions of the tricuspid valve is often difficult. Mechanically, however, the action of this valve is capable of study through its effect upon the peripheral veins, somewhat as the disturbances of the aortic valve are reflected in the peripheral arteries. The conditions to be differentiated are "organic" versus "functional" regurgitation, and obstruction of the valve from rheumatic stenosis. Graphic records of the venous pulse with suitable reference tracings may make this possible.
Celiac Disease: Methods and Protocols
Authors: P D HOWDLE
Journal: Gut (2001)

Celiac Disease: Methods and Protocols . Edited by M N Marsh (Pp 300; US$99.50). Totowa, New Jersey, USA: Humana Press, 2000.

Michael Marsh's latest book on coeliac disease started out at a distinct disadvantage as I took it with a pile of novels to read while on a summer holiday in Provence. However, he need not have worried; this is a distinctive book and, to someone interested in coeliac disease, it came as a refreshing approach to the subject.

Marsh was charged with editing a volume in a new series on “ Methods in Molecular Medicine ”. He was a good choice as he has spent virtually the whole of his professional life working on coeliac disease and, in particular, on the morphology of the intestinal mucosa. He has dedicated the volume to the late Anne Ferguson, who did so much to …
Morphine for management of refractory dyspnoea: Opiates should be used with caution
Authors: J. W Berrill
Journal: BMJ (2003)

Editor—Abernethy et al identify that hypercapnia and respiratory depression are impediments to the use of opiates in patients with chronic obstructive pulmonary disease, yet they do little to allay those concerns in their report.1

Most (88%) of their patients were reported to have chronic obstructive pulmonary disease. This is a diagnosis based on spirometric assessment,2 but they present no such data. Spirometry would give confirmation of the diagnosis, prognostic information and perhaps selection criteria for the intervention. We disagree that measurement of pulmonary function would be neither generalisable nor ethical as spirometry is an easily performed, non-invasive procedure that is widely available.

The authors say that no respiratory depression was identified, but they present no data to support this. Oxygen saturation and respiratory rate, which are reported, may not identify respiratory depression. Alveolar hypoventilation, the result of respiratory depression, is a function of respiratory rate and tidal volume. The only valid parameter to assess respiratory depression is arterial carbon dioxide (Paco2), and while we agree that arterial blood gas sampling is an invasive procedure, minimally invasive procedures such as capillary blood sampling or capnography would have provided useful results as increases in Paco2 are associated with adverse outcomes.

This is particularly relevant since it seems from the discussion that some patients used non-invasive ventilation, presumably for hypercarbic respiratory failure. We recommend that for refractory dyspnoea opiates continue to be used with extreme caution, in chronic obstructive pulmonary disease at least.
Lymphoproliferative disease of 'lak cell' precursor large granular lymphocytes in association with celiac disease
Authors: P. Lopez, D. G. Morris, P. R. Galbraith, D. P. Lillicrap, H. F. Pross
Journal: American Journal of Hematology (1993)

We have investigated a case of lymphoproliferative disease of large granular lymphocytes (LDGL) occurring in association with celiac disease, anemia, neutropenia, and carcinomas of the endometrium, breast, and skin. The large granular lymphocyte (LGL) proliferation was monoclonal, T cell in origin, with T cell receptor beta-chain gene rearrangement, and a CD3+, CD8+, CD16+/- phenotype. In spite of the high frequency of LGL, natural killer (NK) cell activity was absent. Stimulation with interleukin-2 in vitro, however, resulted in high lymphokine-activated killer (LAK) cell activity against NK-resistant targets. The T-cell nature of the LAK precursor cells is in contrast to the majority seen in normal peripheral blood. Therapeutic trials of cyclosporin A, low-dose cyclophosphamide, and levamisole were unsuccessful in reducing transfusion requirements. This case is unique in the association of LDGL with celiac disease. It is also unique in that the patient had been followed for several years prior to the onset of the LDGL. The case extends the list of lymphoproliferative disorders documented to be associated with celiac disease and, conversely, adds to our knowledge of lymphoproliferative disorder of LGL and its "dysimmune" manifestations.
<i>CLC</i>– a novel susceptibility gene for allergic rhinitis?
Authors: M. Bryborn, C. Halldén, T. Säll, L. O. Cardell
Journal: Allergy (2009)

To cite this article: Bryborn M, Halldén C, Säll T, Cardell LO. CLC – a novel susceptibility gene for allergic rhinitis?. Allergy 2010; 65 : 220–228. Abstract Background: Studies of the nasal lavage fluid proteome have previously identified proteins differently expressed in patients with symptomatic allergic rhinitis, e.g. S100A7, prolactin‐inducible protein (PIP), wingless‐type MMTV integration site family, member 2B (WNT2B), Charcot‐Leyden crystal protein (CLC) and palate lung nasal epithelial clone (PLUNC). The aim of the present study was to investigate if genetic variation associated with allergic rhinitis can be found in these genes. Methods: Peripheral blood was collected from 251 patients with birch and/or grass pollen‐induced allergic rhinitis and 386 nonatopic healthy controls. A total of 39 single nucleotide polymorphisms (SNPs) distributed over the genes PIP , WNT2B , CLC and PLUNC were selected from dbSNP, genotyped and investigated for associations with allergic rhinitis. Twelve additional SNPs were subsequently analysed for CLC . Results: All 22 investigated SNPs in CLC were polymorphic. Ten SNPs yielded significant differences between cases and controls with respect to genotype frequencies. Homozygotes for the minor allele were more common in allergic individuals compared to healthy controls. The minor alleles of these SNPs were all located on the same haplotype. Furthermore, homozygotes for the minor allele of two of the promoter SNPs had higher average scores for birch in skin prick test. In contrast, for seven SNPs within the gene, heterozygotes and homozygotes for the major allele had higher average scores for grass. None of the other three genes showed association. Conclusion: Genetic variation in CLC was found to be associated with allergic rhinitis. The pattern of variation is compatible with a recessive inheritance model and the previously observed altered protein levels detected in patients with allergic rhinitis.
Intravesical Bleomycin in Treatment of Carcinoma of the Bladder
Authors: N. Sadoughi
Journal: JAMA (1973)

<h3>To the Editor.—</h3> Bleomycin (Blenoxane), an antibiotic with antineoplastic properties, has been used extensively in the treatment of various malignant tumors in Japan and in the United States. Significant responses have been observed in patients with squamous cell carcinoma of various organs, lymphoma, and testicular tumors. No apparent response was reported in 14 cases with bladder carcinoma that have been treated with systemically administered bleomycin,<sup>1</sup>which is associated with important skin and pulmonary complications especially pulmonary fibrosis. The effectiveness of intravesical application in a patient with bladder carcinoma is presented. <h3>Report of a Case.—</h3> A 76-year-old man underwent transurethral resection of the prostate in early 1972. In October, an excretory urogram revealed minimal blunting of calyces but was otherwise normal. The urine cytologic study disclosed poorly differentiated malignant cells, and bone marrow aspiration showed moderate normoblastic hyperplasia, mild plasmocytosis, but no tumor cells. Cystopanendoscopy showed multiple papillary bladder tumors
Who Will Take Care of the Children?
Authors: Clement A. Smith
Journal: JAMA (1960)

Predictions are offered as to the medical care of tomorrow's predictably numerous children. It is suggested that younger parents and grandparetns are willing to assume, and should be given, a larger share in such care, under medical supervision. Some of that supervision will require pediatric specialists. Most of it should be well within the capabilities of those pediatric generalists who refuse to be bored by it and those family doctors who are willing to keep sufficiently informed in pediatric medicine. It is to be hoped that the allocation of children's medical care will not be officially by directive from Washington, the A.M. A., the Specialty Boards. Children's medical care should be given by those doctors who are most interested and best prepared, many of whom may be not only the children's doctors but also the families' doctors.
Pneumococcal Infection and Gurgling in the Head
Authors: MARK D. WINTON
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 June 1987Pneumococcal Infection and Gurgling in the HeadMARK D. WINTON, M.D., E. DALE EVERETT, M.D., CLARK H. WATTS, M.D.MARK D. WINTON, M.D.Search for more papers by this author, E. DALE EVERETT, M.D.Search for more papers by this author, CLARK H. WATTS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-6-912_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Pneumocephalus is most often seen as a result of surgery or trauma to the central nervous system. We have recently seen a case of spontaneous pneumocephalus that presented as an audible phenomenon to the patient.A 57-year-old woman had a 1-week history of occipital headache treated with analgesics. On the day before admission she noticed a bubbling sensation inside her head. That evening she developed fever and mental status changes. A computed tomographic (CT) scan showed pneumocephalus and an air-fluid level in the left sphenoid sinus. She had a temperature of 38.7 °C, was disoriented, and had...References1. ROBINSON R. Cerebrospinal fluid rhinorrhoea meningitis and pneumoencephalitis due to non-missile injuries. Aust NZ J Surg. 1970;39:328-34. CrossrefMedlineGoogle Scholar2. ANDREWSCANALIS JR. Otogenic pneumocephalus. Laryngoscope. 1986;96:521-8. CrossrefMedlineGoogle Scholar3. HANDSANFORD WJ. Posttraumatic bacterial meningitis. Ann Intern Med. 1970;72:869-74. LinkGoogle Scholar4. MALIWAN N. "Spontaneous" pneumocephalus associated with mixed aerobic-anaerobic bacterial meningitis [Letter]. J. Infect Dis. 1985;152:847-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Missouri Hospital and Clinics Columbia, MO 65212 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPneumocephalus as a Rare Presentation of Acute Sinusitis with Intracranial Extension – Two Cases and a Review of LiteratureAtypical Headache After Prolonged Treatment With Nasal Continuous Positive Airway PressureNeumoencéfalo en el curso de una meningitis neumocócica secundaria a otitis media aguda 1 June 1987Volume 106, Issue 6Page: 912-913KeywordsAnalgesicsCentral nervous systemComputed axial tomographyFeversHead injuryHeadachesTemperatureTrauma surgery Issue Published: 1 June 1987 PDF DownloadLoading ...
Risk of Coronary Artery Disease-Reply
Authors: Jeffrey A. Cutler
Journal: JAMA (1983)

<h3>In Reply.—</h3> Dr Rosch is correct in asserting that evidence of increased incidence of CHD in the presence of certain characteristics (risk factors) does not justify, in itself, the conclusion that they are causative factors. As he recognizes, clinical trials such as the MRFIT are necessary to determine whether intervention on risk factors is effective in reducing morbidity or mortality or both. Hypertension, serum cholesterol, and cigarette smoking were selected for intervention in the MRFIT because of the large amount of data, which include experimental and epidemiologic evidence, implicating them as modifiable causes of CHD.<sup>1</sup> Dr Rosch challenges the choice of intervention mode, but the basis for his objection is not clear. By characterizing why people smoke and why cholesterol or BP levels are elevated as "the most important questions," he seems to give credence to the afore-mentioned body of evidence, implicating the three major CHD risk factors. It
Abstract 3870: Distinct and cooperative functions of the RB and p53 tumor suppressors in genotoxic response and tumorigenesis
Authors: Kathleen McClendon, Jeffry L. Dean, Adam Ertel, Christopher A. Reed, Xiaoping Yang, Erik S. Knudsen
Journal: Cancer Research (2010)

Abstract The compound inactivation of RB and p53 is a frequent occurrence in human cancers. At a molecular level, the RB and p53 pathways intersect at multiple points that have critical implications for cell cycle control and tumorigenesis. To examine the cooperation of these proteins in the response to genotoxic damage, we used a combination of genetic deletion and dominant negative strategies in vitro, and liver-specific genetic deletion in vivo. In vitro, RB proficiency was sufficient to maintain cell cycle checkpoint in response to genotoxic stress, independent of p53 status. In contrast, RB-deficient cells displayed deregulated cell growth, resulting in aggressive recovery from DNA damage. Strikingly, while disruption of the RB and p53 pathways alone does not result in transformation, the RB-deficient, recurred cell populations were tumorigenic. These in vitro findings indicate that RB is a critical suppressor of tumorigenesis, beyond that of p53, and a significant factor in the evolution of cells during genotoxic challenge. To further examine the cooperation of RB and p53 in vivo, a model of liver tumorigenesis was employed. Interestingly, these in vivo studies confirmed that while compound inactivation of the RB and p53 pathways in liver tissue promoted deregulated cell cycle control, this was not sufficient for transformation. However, loss of RB and p53 cooperated in promoting aberrant cell proliferation and mitosis in the presence of genotoxic challenge by DEN (diethyl-nitrosamine), ultimately resulting in enhanced tumorigenesis. Strikingly, loss of RB alone promoted S-phase entry as a result of genotoxic challenge, but there was an uncoupling of this event from productive mitosis. In contrast, the combined loss of RB/p53 resulted in further deregulation of DNA replication that was accompanied by a productive mitotic entry. These data indicate that, while both RB and p53 can contribute to appropriate replicative control, p53 plays a dominant role in mediating G2/M regulation. Furthermore, RB/p53-deficient livers displayed rapid progression to highly aggressive HCC within the span of six months, which was not observed in either RB-deficient or p53-deficient livers. Combined, these studies indicate that RB and p53 play distinct and cooperating roles in modulating response to genotoxic stress and tumorigenesis. Discovering the mechanism behind this cooperation could uncover a critical facet of tumor etiology and provide a means by which to treat this complex disease. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3870.
THE URIC-ACID DELUSION AND THE PREVENTION OF GOUT.
Authors: WOODS HUTCHINSON
Journal: JAMA (1904)

The first requisite to an adequate discussion of the prevention of gout is a clear view of its causation. The one thing which, it seems to me, emerges clearly from the seething caldron of the clinical and chemical researches of the past fifty years is that whatever be the cause of gout it is<i>not</i>uric acid. The first step, then, is to rid our minds of the delusion, that any means which are to cure gout, must be directed toward either increasing or diminishing the formation or promoting the elimination of uric acid or any of its precedents. I fear that to many this position will appear radical to the verge of foolhardiness, but it is the one which appears most rational and tenable to me, and I will, therefore, proceed to sketch very briefly its basis and its bearing on this most important problem, with no further apology,
Inadvertent Atrioventricular Block During Radiofrequency Catheter Ablation
Authors: Michael S. Schaffer, Michael J. Silka, Bertrand A. Ross, John D. Kugler
Journal: Circulation (1996)

Background Inadvertent atrioventricular block is a complication of radiofrequency ablation. The present study is an analysis of the incidence, significance, and factors associated with inadvertent atrioventricular block during radiofrequency catheter ablation in childhood and adolescence. Methods and Results The records of the Pediatric Radiofrequency Ablation Registry were reviewed. Between January 1, 1991, and April 1, 1994, atrioventricular block occurred in 23 of 1964 radiofrequency ablations (1.2%): 14 as third-degree block (3 transient) and 9 as second-degree block (5 transient). Atrioventricular block occurred from 5 seconds to 2 months (mean, 4.1 days; median, 15 seconds) after the onset of the energy application. Eight transient cases lasted 1 hour to 1 month (mean, 9.4 days; median, 7 days). Inadvertent atrioventricular block was related to the ablation anatomic site: 3 of 111 (2.7%) anteroseptal, 11 of 106 (10.4%) midseptal, and 2 of 197 (1.0%) right posteroseptal sites ( P =.0007 for anteroseptal, P =.0001 for midseptal, and P =.17 for right posteroseptal versus nonright septal sites). Five of 314 (1.6%) ablations for atrioventricular nodal reentrant tachycardia resulted in atrioventricular block ( P =.004 versus nonright septal sites). Compared with a matched subgroup, radiofrequency ablation experience was the only significant risk factor (32.7 versus 106.6, P =.002) for the occurrence of atrioventricular block. Conclusions Inadvertent atrioventricular block may occur during or late after radiofrequency catheter ablation. It is associated with ablations for (1) anterior and midseptal accessory pathways and atrioventricular nodal reentry and (2) relative institutional inexperience.
The Adaptor Molecule MyD88 Activates PI-3 Kinase Signaling in CD4+ T Cells and Enables CpG Oligodeoxynucleotide-Mediated Costimulation
Authors: Andrew E. Gelman, David F. LaRosa, Jidong Zhang, Patrick T. Walsh, Yongwon Choi, J. Oriol Sunyer, Laurence A. Turka
Journal: Immunity (2006)
Acceptability in France of Induced Abortion for Adolescents
Authors: María Teresa Muñoz Sastre, Céline Peccarisi, Elizabeth Legrain, Etienne Mullet, Paul Sorum
Journal: The American Journal of Bioethics (2007)

Background: This study investigated the factors affecting the acceptability in France of abortions. Method: 80 study participants from Toulouse and 124 from Metz judged the acceptability of abortion in 64 vignettes composed of five factors: 1) the adolescent's age (15 or 17.5 years), 2) the adolescent's plans to continue schooling or not, 3) the fetus' age (1, 2, 3, or 4 months), 4) the adolescent's parents' agreement or not, and 5) the agreement or not of baby's father. Results: Three clusters were noted: 1) abortion is never acceptable (8% of participants), 2) abortion is always acceptable (23%), and 3) acceptability of abortion depends on the circumstances (63%). In the majority cluster (3), all five factors had significant effects, but the fetus's age accounted for most of the variance (78%). Conclusion: Most subjects in this study judged, in accordance with French law, that the acceptability of induced abortion in minors depends on the circumstances and, in particular, on the fetus' age.
A valine deletion of ferroportin 1: a common mutation in hemochromatosis type 4?
Authors: Antonella Roetto, Alison T. Merryweather-Clarke, Filomena Daraio, Karen Livesey, Jennifer J. Pointon, Giuliana Barbabietola, Antonio Piga, Peter H. Mackie, Kathryn J. H. Robson, Clara Camaschella
Journal: Blood (2002)
Abstract 3191: Immune cell bound MUC16 (CA125): A novel diagnostic marker for ovarian cancer
Authors: Jennifer A. Belisle, Mildred Felder, Arvinder Kapur, Chanel T. Tyler, Joseph P. Connor, Manish S. Patankar
Journal: Cancer Research (2011)

Abstract MUC16 is a cell surface mucin expressed at high levels by epithelial ovarian cancer cells. Following proteolytic cleavage, cell surface MUC16 (csMUC16) is shed (sMUC16) in the extracellular milieu and is detected in the serum of cancer patients as the tumor marker CA125. csMUC16 acts as an adhesion molecule and facilitates peritoneal metastasis of ovarian tumors. Both sMUC16 and csMUC16 also protect cancer cells from cytotoxic responses of natural killer (NK) cells. In a previous study, we demonstrated that sMUC16 binds to a specific subset of NK cells. Here, we demonstrate that in addition to NK cells, sMUC16 also binds to B cells and monocytes isolated from the peripheral circulation and the peritoneal fluid. I-type lectin, Siglec-9, is identified as the sMUC16 receptor on these immune cells. The inhibitory receptor Siglec-9 is expressed on approximately 30-40% of CD16pos/CD56dim NK cells, 20-30% of B cells and &amp;gt;95% of monocytes. sMUC16 binds to the majority of the Siglec-9pos NK cells, B cells and monocytes. sMUC16 is released from the immune cells following neuraminidase treatment. While sMUC16 binds to Siglec-9, it has no affinity for another I-type lectin, Siglec-7. Experiments with Siglec-9 transfected Jurkat cells and monocytes isolated from healthy donors demonstrate that immune cells can bind to ovarian tumor cells via Siglec-9-csMUC16 interaction. sMUC16-Siglec-9 binding is a high affinity and event and the mucin is detected on the surface of the patient-derived immune cells even after the cells have been cultured in vitro in media that does not contain any sMUC16. The MUC16 mucin is also expressed by the human decidua and higher circulating levels of this molecule (measured as CA125) are detected in peripheral circulation of pregnant women. Flow cytometry analysis of immune cells from pregnant women indicates that MUC16 can be detected on the surface of specific subsets of immune cells even when the serum CA125 levels are very low or undetectable. Furthermore, we have observed that sMUC16 is detected on distinct subsets of NK cells of women with preeclampsia as compared to healthy pregnant women and patients with ovarian tumors. Our on-going studies are focused on monitoring sMUC16 binding to specific subsets of immune cells to determine if this information can be used to devise a novel assay for the diagnosis and monitoring of ovarian tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3191. doi:10.1158/1538-7445.AM2011-3191