Rage Reaction Associated with Clorazepate Dipotassium
Authors: FRED E. KARCH
Journal: Annals of Internal Medicine (1979)

Brief Reports1 July 1979Rage Reaction Associated with Clorazepate DipotassiumFRED E. KARCH, M.D.FRED E. KARCH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-1-61 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSeveral of the benzodiazepines including diazepam (1, 2), chlordiazepoxide (2, 3), and clonazepam (4) have been associated with paradoxical rage reactions, whereas other benzodiazepines seem less likely to cause paradoxical rage (5, 6). Clorazepate dipotassium has only been associated with paradoxical rage after an accidental overdose involving a 7-year-old child (7) and in adults with temporal-lobe epilepsy (8). This report describes a paradoxical rage reaction associated with clorazepate dipotassium in an adult.A 24-year-old man had been taking diazepam (10 mg) intermittently for mild anxiety related to marital difficulties. He had run out of diazepam several days earlier, and on...References1. FELDMAN P. An analysis of the efficacy of diazepam. J Neuropsychiatry. 1962;3(suppl):62-7. Google Scholar2. DIMASCIOSHADERGILLER ARD. Behavioral toxicity. Part III: Perceptual-cognitive functions: and Part IV: Emotional (mood) states. In: SHADER RI, DIMASCIO A, eds. Psychotropic Drug Side Effects. Baltimore: Williams and Wilkins; 1970:132-41. Google Scholar3. INGRAMTIMBURY IG. Side-effects of Librium. Lancet. 1960;2:766. Letter. CrossrefGoogle Scholar4. BLADIN P. The use of clonazepam as an anti-convulsant—clinical evaluation. Med J Aust. 1973;1:683-8. CrossrefMedlineGoogle Scholar5. GARDOSDIMASCIOSALZMANSHADER GACR. Differential actions of chlordiazepoxide and oxazepam on hostility. Arch Gen Psychiatry. 1968;18:757-60. CrossrefMedlineGoogle Scholar6. KOCHANSKYSALZMANSHADERHARMATZOGELTREE GCRJA. The differential effects of chlordiazepoxide and oxazepam on hostility in a small group setting. Am J Psychiatry. 1975;132:861-3. CrossrefMedlineGoogle Scholar7. LIONAZCARATEKOEPKE JCH. "Paradoxical rage reactions" during psychotropic medication. Dis Nerv Syst. 1975;36:557-8. MedlineGoogle Scholar8. FELDMAN R: Clorazepate in temporal lobe epilepsy. JAMA. 1976;236:2603. Letter. CrossrefMedlineGoogle Scholar9. SALZMANDIMASCIOSHADERHARMATZ CARJ. Chlordiazepoxide, expectation and hostility. Psychopharmacologia. 1969;14:38-45. CrossrefMedlineGoogle Scholar10. SALZMANKOCHANSKYSHADERPORRINOHARMATZSWETT CGRLJC. Chlordiazepoxide-induced hostility in a small group setting. Arch Gen Psychiatry. 1974;31:401-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Rochester School of Medicine and Dentistry Rochester, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBenzodiazepine use and aggressive behaviour: A systematic reviewBarbituriques et autres hypnotiques et sédatifsBarbiturates and Other Hypnotics and SedativesComparison of the Frequency of Behavioral Disinhibition on Alprazolam, Clonazepam, or No Benzodiazepine in Hospitalized Psychiatric PatientsReconciling the role of central serotonin neurons in human and animal behaviorSearching for an ill-defined brain function results in an uneasy reconciliationPersonality traits and neurotransmitters: Complexity vis-à-vis complexityBenzodiazepines, serotonin, and conflict behaviorMultiple 5-HT systems and multiple punishment processesThe role of serotonin in behavior: An unfulfilled promise5-Hydroxytryptamine, aversion, and anxietySerotonin and aggression: What kind of relationship?An overdue burial for the serotonin theory of anxietyIs there a role for serotonin in anxiety?Serotonin, simians, and social settingThe involvement of serotonergic mechanisms in anxiety and impulsivity in humansModulating function of central serotonin neuronsStrategies for studying brain–behavior relationshipsControlling a neuron bombIs serotonin related to inhibition or generation and control of motor activity?Serotonin depletion and inhibition: Running the rat race without any brakes?Serotonin, impulsivity, and emotionalityA lonesome Français in serotonin countryDiagnosis and Treatment of Drug OverdoseThe Intensive Care Unit Syndrome: Causes, Treatment, and PreventionBenzodiazepinesProgesterone, fluid, and electrolytes in premenstrual syndrome.Gonorrhoea presenting as "sterile" pyuria.Gonorrhoea presenting as "sterile" pyuriaSystematic review of the benzodiazepines.Heart rate variations in the Guillain-Barre syndrome.No to euthanasia.Hostility Reaction to FlurazepamClinical Significance 1 July 1979Volume 91, Issue 1Page: 61-62KeywordsAnxietyDiazepamEpilepsy Issue Published: 1 July 1979 PDF downloadLoading ...