tbuckley/cabot-search huggingface dataset:
Major Challenges in Providing an Effective and Timely Pandemic Vaccine for Influenza A(H7N9)
Authors: Michael T. Osterholm, Katie S. Ballering, Nicholas S. Kelley
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Accuracy of Stated Energy Contents of Restaurant Foods
Authors: Lorien E. Urban, Megan A. McCrory, Gerard E. Dallal, Sai Krupa Das, Edward Saltzman, Judith L. Weber, Susan B. Roberts
Journal: JAMA (2011)

National recommendations for the prevention and treatment of obesity emphasize reducing energy intake. Foods purchased in restaurants provide approximately 35% of the daily energy intake in US individuals but the accuracy of the energy contents listed for these foods is unknown.
Reprogrammed Fibroblasts Form a Functional Thymus
Authors: Tracy Hampton
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tailoring Chronic Pain Care by Brief Assessment of Impact and Prognosis Comment on “Point-of-Care Prognosis for Common Musculoskeletal Pain in Older Adults”
Authors: Michael Von Korff
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
THE VALUE OF EYE SYMPTOMS IN THE DIAGNOSIS OF GENERAL DISEASES
Authors: H. G. A. Gjessing
Journal: BMJ (1934)

It is often said that the ophthalmologist is merely a specialist.This, however, I hope to be able to contradict.He is and must be-if he really wishes to fill his place- a general physician just as much as the general practitioner.Sir Archibald Garrod impressed this upon us in his speech at Oxford in 1927.His subject was the con- nexion between
The Doctor with Two Heads -- The Patient versus the Costs
Authors: Fredrick R. Abrams
Journal: New England Journal of Medicine (1993)

Once upon a time there was a doctor who awakened one morning with a splitting headache. As he groggily approached his shaving mirror in the dim light, he thought he was hallucinating and vowed to consume no more midnight snacks of smoked oysters and sliced onion. “Splitting” had indeed been the appropriate adjective to describe his headache, for to his utter amazement he saw, as his vision cleared, that he had grown a second head. Examining his second head closely, he saw that it was identical in appearance to his original head, and, much like that of his child's pet . . .
Tranglutaminase 2 Gene Deficiency Results In Decrease Of Airway Resistance And Eosinophilic Inflammation In Murine Asthma Model
Authors: H. Lee, E. Shim, J. Jung, H. Kang, H. Park, S. Kim, S. Cho, S. Chang, K. Min, Y. Kim
Journal: Journal of Allergy and Clinical Immunology (2011)
Fundamentals of Orthopaedics
Authors: Leonard Marmor
Journal: JAMA (1965)

<h3>Outline of Orthopaedics.</h3> By John Crawford Adams. 5th ed. 471 pp, 328 illus. $7.50. Williams &amp; Wilkins Co., 428 E Preston St, Baltimore 2, 1964 <i>Fundamentals of Orthopaedics</i>was written primarily for the medical student, as a basic introduction to the rapidly expanding field of orthopedics. Its 14 chapters cover congenital disorders, arthritis, infections, bone tumors, and musculoskeletal disorders of the various areas of the body. A chapter on fracture management presents the basic principles, but the management of compound fractures is treated in a brief paragraph and might have been enlarged. In the chapter on arthritis, the orthopedic surgical correction of deformities is completely omitted from the section on treatments and some of the newer concepts should have been included. The general format of the book is very good and the illustrations, both roentgenograms and drawings, are of excellent quality and reproduced very well. The text of the book
SAFEGUARDS IN CATARACT EXPRESSION
Authors: JOHN GREEN
Journal: JAMA (1926)

In an effort to safeguard every step in the expression1of cataract after capsulotomy, the routine here described has been developed. This paper deals solely with certain points in operative technic; hence the general preoperative preparation of the patient will not be discussed.  LOCAL PREPARATION  A culture is made in every case. If the conjunctival sac is clinically clean and there is no evidence of dacryocystitis, little attention is paid to the bacteriologic report. Atropine, 2 per cent, is instilled one hour and also one-half hour before operation. The lids, lashes and ocular adnexa are thoroughly scrubbed with liquid soap. The eye is then flooded with from 10 to 15 drops of a 4 per cent solution of strong silver protein, which is allowed to remain in contact with the conjunctiva for five minutes. A stream of a tepid solution of boric acid (2 per cent) rather forcibly washes
Feasibility of Preoperative Single Fraction Partial Breast Radiotherapy for Early Stage Breast Cancer.
Authors: M. Palta, S. Yoo, J. Horton
Journal: Cancer Research (2009)

Abstract Introduction: Preliminary data supports the efficacy of partial breast irradiation (PBI) in carefully selected patients. However, in 2008, several series evaluating external beam PBI reported negative toxicity outcomes, possibly related to large volumes of normal tissue receiving near-prescription doses.We hypothesized that delivery of external beam PBI in a single fraction to the preoperative tumor volume, as defined by magnetic resonance imaging (MRI), would be dosimetrically feasible and result in decreased dose to the ipsilateral breast as compared to institutional historical controls.Methods: Ten patients with unifocal T1 breast cancer who had undergone a preoperative MRI were identified. Contrast-enhanced subtraction MR images were loaded into Eclipse treatment planning software and used to define the gross tumor volume (GTV). A 1.5cm uniform expansion (minus first 5mm of skin) was used to generate the clinical target volume (CTV) for dose-volume analysis. An additional 2-3 mm margin was included for penumbra.The first 3mm of skin/subcutaneous tissue was defined as an avoidance structure. Bilateral lungs and heart were segmented. A prospective “virtual plan” was created using four photon beams in a non-coplanar beam arrangement and optimized to deliver 15Gray (Gy) to the CTV.Specific dosimetric data was extracted including dose conformity (breast volume receiving 100% of the dose/CTV) and dose to the ipsilateral breast, ipsilateral lung, and heart.Results: The median breast volume was 1713cc's (range 1014 – 2140cc's) and the median target volume only 41cc's (26-62cc's). In all cases, 95% of the prescription dose covered 100% of the CTV volume. Median dose conformity was 1.2 (range 1.1-1.6). Maximum dose for all plans was not greater than 110%. Doses to the heart and lung were negligible.Median maximum skin dose was 9.3Gy or 62% of the prescription dose. Median maximum dose to 1cc of skin was reduced to 7.0Gy and at 10cc's skin volume, the median maximum was only 4.9Gy.Median percent of the ipsilateral breast volume receiving 100% of the dose (V100) was only 3.5% (range 2.4-4.7%). The median percent volume receiving 50% of the dose (V50) was 13% (range 7.5-20.8%), substantially less than institutional experience with post-operative PBI. Pre-operative PBIPost-operative PBI n=10n=27 Median (range)Median (range)V1003.5% (2.4-4.7)20% (3-42)V5013% (7.5-20.8)43% (24-65) Conclusion: Pre-operative radiotherapy is dosimetrically feasible in women with small breast tumors. Excellent target coverage with negligible dose to normal tissue can be achieved. Skin dose appears reasonable given the small volumes.Median V100 and V50 compare favorably to institutional experience with post-operative PBI. A prospective Phase I trial evaluating this technique is undergoing institutional review. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 4105.
Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype
Authors: Maryam Ahmadian, Marcia J. Abbott, Tianyi Tang, Carolyn S.S. Hudak, Yangha Kim, Matthew Bruss, Marc K. Hellerstein, Hui-Young Lee, Varman T. Samuel, Gerald I. Shulman, Yuhui Wang, Robin E. Duncan, Chulho Kang, Hei Sook Sul
Journal: Cell Metabolism (2011)
Falsely Positive Radionuclide Venogram Following DTPA Aerosol Ventilation Scan
Authors: PAUL S. SIROTTA, THEODORE J. DUBINSKY
Journal: Clinical Nuclear Medicine (1987)

Following a Tc-99m DTPA aerosol ventilation scan, a venogram performed with Tc-99m MAA showed what appeared to be partial occlusion of the left common iliac vein, with collaterals arising from the point of obstruction. Swallowed DTPA in bowel was the culprit.
Biological Variation in HbA1c Predicts Risk of Retinopathy and Nephropathy in Type 1 Diabetes
Authors: Robert J. McCarter, James M. Hempe, Ricardo Gomez, Stuart A. Chalew
Journal: Diabetes Care (2004)

OBJECTIVE—We hypothesized that biological variation in HbA1c, distinct from variation attributable to mean blood glucose (MBG), would predict risk for microvascular complications in the Diabetes Control and Complications Trial (DCCT). RESEARCH DESIGN AND METHODS—A longitudinal multiple regression model was developed from MBG and HbA1c measured in the 1,441 DCCT participants at quarterly visits. A hemoglobin glycation index (HGI = observed HbA1c - predicted HbA1c) was calculated for each visit to assess biological variation based on the directional deviation of observed HbA1c from that predicted by MBG in the model. The population was subdivided by thirds into high-, moderate-, and low-HGI groups based on mean participant HGI during the study. Cox proportional hazard analysis compared risk for development or progression of retinopathy and nephropathy between HGI groups controlled for MBG, age, treatment group, strata, and duration of diabetes. RESULTS—Likelihood ratio and t tests on HGI rejected the assumption that HbA1c levels were determined by MBG alone. At 7 years’ follow-up, patients in the high-HGI group (higher-than-predicted HbA1c) had three times greater risk of retinopathy (30 vs. 9%, P &amp;lt; 0.001) and six times greater risk of nephropathy (6 vs. 1%, P &amp;lt; 0.001) compared with the low-HGI group. CONCLUSIONS—Between-individual biological variation in HbA1c, which is distinct from that attributable to MBG, was evident among type 1 diabetic patients in the DCCT and was a strong predictor of risk for diabetes complications. Identification of the processes responsible for biological variation in HbA1c could lead to novel therapies to augment treatments directed at lowering blood glucose levels and preventing diabetes complications.
Roller skating--is it a dangerous sport?
Authors: P Y Tse, W Y Shen, K M Chan, P C Leung
Journal: British Journal of Sports Medicine (1987)

A prospective survey of 111 cases of roller skating injuries within one year are reported. Males were more commonly injured than females. There was a high incidence (86%) of serious injuries, 28% of which required surgical treatment. The wrist (23%) was the commonest region involved, followed by the shoulder (20%), the elbow (15%) and the ankle (12%). Collision with other skaters and loss of control were the main factors leading to injury. Better rink discipline, instruction classes and safety publicity should be helpful in minimising accidents.
Medical Management of Pulmonary Diseases
Authors: Kenneth W. Presberg
Journal: Annals of Internal Medicine (2001)

Medical Writings: Book Notes5 June 2001Medical Management of Pulmonary DiseasesKenneth W. Presberg, MDKenneth W. Presberg, MDDivision of Pulmonary and Critical Care Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin. (Presberg)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-11-200106050-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Davis GS, ed. 795 pages. New York: Marcel Dekker; 1999. $225.00. ISBN 0824760026. Order phone 800-228-1160.Field of medicine: Clinical pulmonology.Purpose: To provide a practical resource on pulmonary diseases, with an emphasis on clinical management.Audience: General internists, fellows in subspecialty areas, subspecialists, and trainees.Content: The book includes sections on pulmonary anatomy and physiology, pulmonary signs and symptoms, common diagnostic studies, diagnostic and treatment dilemmas, common therapies, and important specific diseases. Many chapters include tables that summarize key issues of diagnosis and management. Radiographs and figures are included in selected chapters.Highlights: The book is easier to read ... Author, Article, and Disclosure InformationAffiliations: Division of Pulmonary and Critical Care Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin. (Presberg) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 June 2001Volume 134, Issue 11Page: 1086KeywordsPathogenesisPulmonary diseasesPulmonary medicinePulmonary vascular diseasesRespiratory physiologyRespiratory system proceduresSigns and symptomsSoftware toolsSub-specialty careVasculitis ePublished: 5 June 2001 Issue Published: 5 June 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The effect of metoclopramide on gastric emptying of solid meals
Authors: B. D. Hancock, E. Bowen-Jones, R. Dixon, I. W. Dymock, D. J. Cowley
Journal: Gut (1974)

The effect of metoclopramide has been studied on the emptying of solid meals labelled with <sup>51</sup>Cr and monitored with a gamma camera. Metoclopramide, 10 mg iv or a dummy injection, was given randomly and double blind to 10 normal subjects and to 10 patients within three months of a truncal vagotomy and pyloroplasty. All were tested in the recumbent position. Metoclopramide had no effect on emptying rates in the normal subjects nor in four postvagotomy patients who had emptying within the normal range (T½ 30-150 min). In six patients with abnormally delayed emptying (mean T½ 369 min) metoclopramide produced a significant improvement (mean T½ 194 min, p &lt; 0·01).
Schizophrenia as segmental progeria
Authors: Evangelos Papanastasiou, Fiona Gaughran, Shubulade Smith
Journal: Journal of the Royal Society of Medicine (2011)

Schizophrenia is associated with a variety of physical manifestations (i.e. metabolic, neurological) and despite psychotropic medication being blamed for some of these (in particular obesity and diabetes), there is evidence that schizophrenia itself confers an increased risk of physical disease and early death. The observation that schizophrenia and progeroid syndromes share common clinical features and molecular profiles gives rise to the hypothesis that schizophrenia could be conceptualized as a whole body disorder, namely a segmental progeria. Mammalian cells employ the mechanisms of cellular senescence and apoptosis (programmed cell death) as a means to control inevitable DNA damage and cancer. Exacerbation of those processes is associated with accelerated ageing and schizophrenia and this warrants further investigation into possible underlying biological mechanisms, such as epigenetic control of the genome.
Reporting Enrollment in Clinical Trials
Authors: Gregory A. Abel
Journal: Annals of Internal Medicine (2002)

Letters17 December 2002Reporting Enrollment in Clinical TrialsGregory A. Abel, MD, MPHGregory A. Abel, MD, MPHMassachusetts General Hospital; Boston, MA 02114Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-12-200212170-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Although Gross and colleagues' study (1) was itself a cross-sectional review, it was excellent to see that the authors provided enough information to calculate the recruitment fraction in their own work. If we consider the RCTs they found eligible for study (n = 172) divided by the potential number identified (n = 215), their eligibility fraction is 0.80. If we then consider the number of RCTs that reported adequate data for analysis (n = 81) as “enrolled,” Gross and colleagues' enrollment fraction is 81 divided by 172, or 0.47. Finally, their recruitment fraction would be 0.47 multiplied ...Reference1. Gross CP, Mallory R, Heiat A, Krumholz HM. Reporting the recruitment process in clinical trials: who are these patients and how did they get there? Ann Intern Med. 2002;137:10-6. [PMID: 12093240] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Massachusetts General Hospital; Boston, MA 02114 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoReporting the Recruitment Process in Clinical Trials: Who Are These Patients and How Did They Get There? Cary P. Gross , Raburn Mallory , Asefeh Heiat , and Harlan M. Krumholz Reporting Enrollment in Clinical Trials Cary P. Gross and Harlan Krumholz Reporting Enrollment in Clinical Trials Scott D. Halpern Reporting Enrollment in Clinical Trials Joseph H. Friedman Metrics 17 December 2002Volume 137, Issue 12Page: 1007KeywordsClinical trial reportingResearch design ePublished: 17 December 2002 Issue Published: 17 December 2002 CopyrightCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Acute Peripheral Circulatory Failure in Surgical Cases
Authors: H. D. Ritchie
Journal: BMJ (1956)

A, study has been made of the nasal organ of fish, with particular reference to the distribution of olfactory mucosa and of secretory epithelium.A comparison is made with the nose of mammals, in which there is typically an anterior air-conditioning part and a posterior olfactory region.Observation of a representative series of mammals reveals a correspondence between the olfactory and the humidifying areas and indicates a relation between the two, both areas being small in species with feeble powers of scent and extensive in keen-scented animals.The epithelium generally known as respiratory is found to be of two types, one ciliary and the other thin and permeable.The conclusion is that the present views on nasal physiology require readjustment.Figs. 1, 2, 3, and 5, and the Table, appeared in Annlals of Royal College of Surgeonzs of Englanid, 1954, vol. 15,Sept., and Fig. 4
Increased levels of high sensitive C‐reactive protein in patients with chronic rheumatic valve disease: evidence of ongoing inflammation
Authors: Zehra Gölbasi, Özgül Uçar, Telat Keles, Ahmet Sahin, Kerim Çagli, Ahmet Çamsari, Erdem Diker, Sinan Aydogdu
Journal: European Journal of Heart Failure (2002)
Abstract 501: The carboxypeptidase inhibitor TIG1 interacts with cathepsin L2 and inhibits cathepsin L2-stimulated cellular invasion
Authors: Shun-Yuan Jiang, Fu-Ming Tsai, Rong-Yaun Shyu, Chang-Chieh Wu, Tzung-Chieh Tsai, Chun-Hua Wang
Journal: Cancer Research (2012)

Abstract The tazarotene-induced gene 1 (TIG1), also known as retinoic acid receptor responder 1 (RARRES1), is a putative tumor suppressor gene. The gene encodes a carboxypeptidase inhibitor for ATP/GTP binding protein-like 2 (AGBL2). This study identified TIG1 binding proteins and characterized the activities of TIG1 on cellular invasion of HCT116 colon cancer cells stimulated by the cathepsin L2 (CTSL2). The cytoplasmic portion of the TIG1A isoform was used for identification of TIG1 binding proteins using the yeast two-hybrid screening, and six genes, CTSL2, DNAJC8, SPATA22, SPINK2, VAC14, and C6orf225, were selected. CTSL2, a cysteine protease with an increased expression shown in breast and colon carcinomas, was selected for analysis. Immunoprecipitation analysis using transiently transfected cytosols confirmed the binding between both TIG1 isoforms and CTSL2. Both TIG1A and CTSL2 were secreted proteins; however, the interaction of both proteins in culture supernatants was not detected. Further immunoprecipitation analysis using purified recombinant proteins demonstrated direct binding between both TIG1 isoforms and CTSL2. Cellular invasion of HCT116 cells was increased by 52 to 71% in CTSL2 transiently transfected cells. Both TIG1 isoforms had no effects on cellular invasion of HCT116 cells. However, TIG1A and TIG1B significantly inhibited CTSL2-stimulated cellular invasion by 65.1 and 62.9%, respectively. In conclusion, both TIG1 isoforms interact with CTSL2 and inhibited CTSL2-stimulated cellular invasion of HCT116 cells. The results suggest that TIG1 may suppress CTSL2-mediated cellular invasion through inhibiting the activation of CTSL2 protease, and merit for further investigation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 501. doi:1538-7445.AM2012-501