tbuckley/cabot-search huggingface dataset:
GP tests feasibility of putting patients' records on internet
Authors: Michael Cross
Journal: BMJ (2006)

A GP in England last week claimed to be the first NHS doctor to make patients' records available on the internet. Richard Fitton, of Hadfield Medical Centre, Glossop, posted the notes of two volunteers on a commercially run website as part of a programme to test the feasibility of giving patients, and any other authorised individual, access to their records from anywhere in the world. At least two other GPs are also planning to recruit patients to the programme.

The trial anticipates by several years the plan by the NHS's national programme …
TCTAP A-095 Impact of Proton Pump Inhibitor on One-Year Clinical Outcomes in Patients Underwent Percutaneous Coronary Intervention According to Dual Versus Triple Antiplatelet Agents
Authors: Sang-Ho Park, Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Shaopeng Xu, Jabar Ali, Harris Ngow, Ji Bak Kim, Cheol Ung Choi, Eung Ju Kim, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2015)
Abstract 4502: DNA ploidy in tumor correlates with age, and explains some of the poor prognostic impact of age in endometrial carcinomas
Authors: Karen K. Mauland, Elisabeth Wik, Henrica MJ Werner, Jone Trovik, Helga B. Salvesen
Journal: Cancer Research (2012)

Abstract Background: Endometrial cancer incidence is increasing in industrialized countries, and the demand for better prognostic markers in order to individualize treatment is emerging. DNA ploidy has previously shown independent prognostic impact in smaller studies. In this study, we wanted to investigate the prognostic impact of ploidy in primary endometrial tumors, and the link between DNA ploidy and patient age at diagnosis in relation to traditional clinicopathologic prognostic variables. Study design: 663 patients treated for endometrial carcinoma at Haukeland University Hospital, Norway, from 1981 through 2010 were included. DNA ploidy in fresh tumor specimens was measured by flow-cytometry. Comprehensive clinical and histopathologic data, treatment and complete follow-up were collected. The software PASWStatistics18 was used for statistical analysis. Results: DNA aneuploidy was significantly correlated to high patient age at diagnosis (p&amp;lt;0.001). It was also correlated to non-endometrioid histology and high-grade tumors (p&amp;lt;0.001) and high FIGO stage (p=0.012). In univariate survival analysis (Kaplan Meier), the 5-year disease specific survival of patients with diploid tumors was 89%, versus 65% for aneuploid tumors (p&amp;lt;0.001). In Cox regression analysis, aneuploidy was significantly associated with poor survival (HR=2.4, 95%CI 1.6 - 3.8, p&amp;lt;0.001), adjusted for FIGO stage, age, grade, and histologic subtype. Interestingly, the prognostic impact of patient age diminished when ploidy status was included in the Cox analysis. Conclusion: DNA ploidy estimation in endometrial carcinoma tumor tissue is highly associated with patient age at diagnosis, as well as prognosis. The prognostic impact of age decreases when adjusting for ploidy status in tumor. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4502. doi:1538-7445.AM2012-4502
Coming to Terms
Authors: Suzanne Freeman
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transfusions of Polymerized Bovine Hemoglobin in a Patient with Severe Autoimmune Hemolytic Anemia
Authors: John Mullon, George Giacoppe, Cynthia Clagett, David McCune, Thomas Dillard
Journal: New England Journal of Medicine (2000)

Hemoglobin solutions have several potential advantages as substitutes for erythrocytes for transfusion. Hemoglobin solutions have a prolonged shelf life, are associated with a lower risk of transfusion reactions, and provide faster uptake of oxygen.1 Hemoglobin-based oxygen carriers (HBOC) have been studied primarily in patients with hemorrhage, but the absence of cell-surface antigens in these solutions suggests that they may have a role in the treatment of autoimmune hemolytic anemias. We report the use of a polymerized bovine hemoglobin, HBOC-201 (Hemopure, Biopure, Cambridge, Mass.), in a woman with severe autoimmune hemolytic anemia. Case Report A 21-year-old woman with a petechial rash . . .
Renal vascular disease in African-Americans and other racial minorities.
Authors: N B Shulman, W D Hall
Journal: Circulation (1991)

Hypertensive end-stage renal disease is about 10-fold more common nationwide in African-Americans than in Caucasians and 17-fold higher in some sections of the United States. These figures are alarming and require a much greater effort in understanding the causes of this disparity and improving blood pressure control in this population to prevent catastrophic renal damage. More information is also needed about the renovascular status of other minorities. Financial obstacles to antihypertensive care appear to be an important contributing factor to the disparities of end-stage renal disease in African-Americans and perhaps other minorities.
Production of oxygen-centered radicals by neutrophils and macrophages as studied by electron spin resonance (ESR).
Authors: J V Bannister, W H Bannister
Journal: Environmental Health Perspectives (1985)

Neutrophils and macrophages undergo a respiratory burst and an increase in the activity of the hexose monophosphate pathway in response to particulate or soluble agents. The increase in oxygen consumption was found to be associated with the production of oxygen-centered radicals. The ESR technique of spin trapping showed that besides a superoxide spin adduct, a hydroxyl spin adduct is also produced. ESR is considered to be the least ambiguous technique for the detection of free radicals. The spin-trapping agents used for oxygen-centered radical detection are usually nitrones. The most commonly used nitrone is 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), which reacts with O2-. to form 5,5-dimethyl-2-hydroperoxypyrroline-N-oxide (DMPO-OOH) and with OH. to form 5,5-dimethyl-2-hydroxypyrroline-N-oxide (DMPO-OH). Although spin-adduct formation is considered to be the most direct technique for the detection of free radicals, some disadvantages are encountered. There has been considerable interest in the isolation of the O2-. generating activity from phagocytic cells. The enzyme can be extracted with deoxycholate and gel filtration indicates that it is a high molecular weight complex. Maximum activity was between pH 7.0 and pH 7.5. The Km value was 15.8 microM for NADPH and 434 micron for NADH, indicating that NADPH is the preferred substrate.
S98 Early Clinical Experience with Pirfenidone For Idiopathic Pulmonary Fibrosis (IPF) in the UK: Interim Results from a UK Cohort
Authors: H Parfrey, C Leonard, MA Gibbons, E Harris, R Frank, C Sharp, RM Dew, TM Maher
Journal: Thorax (2012)

<h3>Introduction and Objectives</h3> In March 2011, the novel anti-fibrotic, pirfenidone (Esbriet®), became the first drug to be licenced in Europe for the treatment of IPF. Since September 2011 pirfenidone has been available in the UK through a named patient programme (NPP). We present initial findings from a real-world study describing clinical experience with pirfenidone in routine UK clinical practise. <h3>Methods</h3> A multi-centre, retrospective, cohort review was undertaken across 4 NHS Trusts. Data (through to July 2012) were collected from the clinical records of individuals receiving pirfenidone for IPF through the NPP. <h3>Results</h3> Data was available from 68 patients (72% Male). Mean (±S.D.) age at diagnosis was 67.3±8.1 years. At initiation of pirfenidone FVC was 69.4±21.5% predicted and DLco 39.8±15.3% predicted. Domiciliary oxygen was being administered to 38.2% (26/68). At day 15, following a 14-day titration period, 92.3% (60/65) were receiving the recommended dose of 2403 mg/day pirfenidone. One patient had discontinued treatment. Data was available for 53 patients at 3 months; 42 (79.2%) continued to receive pirfenidone, whilst 11 (20.8%) had stopped therapy. Between 3 and 6 months, 93.1% (27/29) continued pirfenidone with only 2 further patients (6.9%) stopping treatment. Of the 68 patients, 30 (44.1%) experienced an adverse drug reaction (ADR) resulting in a change of dose or cessation of pirfenidone. The commonest ADRs were GI-upset and photosensitive rash. Of those experiencing ADRs, with data available, 12/22 (54.5%) continued pirfenidone after a dose-reduction. In 53 patients for whom pre-treatment liver function tests were available, only two showed a minor increase above the upper limit of normal. During the observation period 10.3% (7/68) of patients suffered an acute exacerbation. Collection of data to determine effect of pirfenidone on lung function at 6 months of treatment is on-going. <h3>Conclusions</h3> Patients enrolled in the NPP are demographically representative of the UK IPF population but have moderately severe disease that is on average more advanced than that seen in the CAPACITY study. Pirfenidone treatment is reasonably well tolerated. On-going observation of patients enrolled in the UK NPP should provide invaluable insights into the real-world benefits of pirfenidone in individuals with IPF.
A randomized, double-blind, parallel-group, duration-finding study of oral terbinafine and open-label, high-dose griseofulvin in children with tinea capitis due to Microsporum species
Authors: J. Lipozencic, M. Skerlev, R. Orofino-Costa, V.C. Zaitz, A. Horvath, E. Chouela, G. Romero, N. Gourmala, C. Paul
Journal: British Journal of Dermatology (2002)

Summary Background Tinea capitis, a common clinical pattern of dermatophyte infection in children is becoming a public health hazard in some countries. Several studies have reported terbinafine to be a safe and well‐tolerated fungicidal drug for the treatment of this infection. However, the optimal treatment duration for its use in the treatment of tinea capitis caused by Microsporum species has not yet been determined. Objective (i) To establish the optimal duration for terbinafine treatment to bring about complete cure of tinea capitis due to Microsporum infection in a large paediatric population, and (ii) to obtain information on the maximum therapeutic effect of the existing therapy. Patients and methods This parallel‐group, double‐blind, multicentre study was conducted in Europe and South America. Patients were randomized to one of four oral terbinafine treatment arms (6, 8, 10 or 12 weeks treatment) or to an open label, 12‐week, high‐dose griseofulvin (20 mg kg−1 day−1) arm at a 1 : 1 : 1 : 1 : 1 ratio. All patients were followed up for 4 weeks after the end of the treatment phase. Results In this group of 134 intention‐to‐treat patients, effective treatment was observed at the end of study in 62% of patients treated with terbinafine for 6 weeks and in 63% treated for 8 weeks. Mycological cure was obtained in 59% and 57%, respectively, and clinical cure in 76% and 80%. In the griseofulvin group, effective treatment was 88%, mycological cure was 76% and clinical cure 96%. However, these high rates were believed to be due to the high dosage of this drug and the prolonged course of treatment. Complete cure was observed at the end of study in 62% patients treated with terbinafine for 6 weeks, in 60% treated for 8 weeks and in 84% patients treated with griseofulvin for 12 weeks. Conclusions Although there was no statistical trend between the duration of terbinafine treatment within the groups for complete cure at the end of study, there was a positive correlation between the daily dose of terbinafine (mg kg−1) and complete cure. Terbinafine therapy for 6 weeks could represent an alternative to griseofulvin for the treatment of Microsporum tinea capitis. However, further clinical trials are required in order to optimize the dose regimen to allow higher cure rates to be reached.
Can CCL2 serum levels be used in risk stratification or to monitor treatment response in systemic sclerosis?
Authors: M T Carulli, C Handler, J G Coghlan, C M Black, C P Denton
Journal: Annals of the Rheumatic Diseases (2007)

The chemokine CCL2 has been consistently found to be up-regulated in systemic sclerosis. To explore the potential value of serum CCL2 measurement in disease assessment, we have compared CCL2 levels with clinical phenotype and investigated effect of therapy on circulating CCL2.Serum samples from a well characterised cohort of 94 systemic sclerosis (SSc) patients, 16 patients with primary Raynaud phenomenon and 11 healthy controls were examined by ELISA. Our cohort of patients included 50 patients with limited cutaneous (lc)SSc (20 with lcSSc alone and 30 with pulmonary arterial hypertension-lcSSc), and 44 with diffuse cutaneous (dc)SSc, 30 of which had early-onset dcSSc.Serum levels of CCL2 were increased in both major SSc subsets. In early stage dcSSc 18/30 (60%) cases demonstrated markedly elevated CCL2, and this was associated with anti-topoisomerase or anti-RNA polymerase I/III antibody reactivity, and with greater frequency of major organ-based complications. Elevation of CCL2 serum levels in the lcSSc subset was not associated with pulmonary arterial hypertension, although there was a trend for reduction following treatment with prostacyclin analogues or bosentan.These findings suggest that the CCL2/CCR2 axis is a potential therapeutic target in SSc, particularly in the early dcSSc subset. CCL2 measurement may be useful for risk stratification in early stage disease, but its value in disease monitoring is questionable.
General Practice in British Columbia
Authors: J. Sumner
Journal: BMJ (1966)

that thoughtless minority who are out to claim all they can without concern for their doctor's discomfiture.Rather than embark on propaganda designed to prevent abuse of a tottering ser- vice I look forward to the day when a more positive approach becomes evident-namely, providing the general practitioner with the proper premises and facilities so badly needed to cope adequately with the sort of medicine required of him in this modern age.If distributing leaflets is the best that can be done I hope the planners find other means of so doing rather than through us.-Iam, etc., Resolven, Glam.
Creative Arts Therapies Defined
Authors: Joke Bradt, Sheryl Goodill
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Myocardial Infarction Induced by Appetite Suppressants in Malaysia
Authors: Shah M Azarisman, Yahya A Magdi, Saidin Noorfaizan, Maskon Oteh
Journal: New England Journal of Medicine (2007)

The authors report on two otherwise healthy young women who had myocardial infarction with acute ST-segment elevation associated with the use of phentermine and sibutramine.
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
Authors: Chad A. Dickey, Adeela Kamal, Karen Lundgren, Natalia Klosak, Rachel M. Bailey, Judith Dunmore, Peter Ash, Sareh Shoraka, Jelena Zlatkovic, Christopher B. Eckman, Cam Patterson, Dennis W. Dickson, N. Stanley Nahman, Michael Hutton, Francis Burrows, Leonard Petrucelli
Journal: Journal of Clinical Investigation (2007)

A primary pathologic component of Alzheimer's disease (AD) is the formation of neurofibrillary tangles composed of hyperphosphorylated tau (p-tau). Expediting the removal of these p-tau species may be a relevant therapeutic strategy. Here we report that inhibition of Hsp90 led to decreases in p-tau levels independent of heat shock factor 1 (HSF1) activation. A critical mediator of this mechanism was carboxy terminus of Hsp70-interacting protein (CHIP), a tau ubiquitin ligase. Cochaperones were also involved in Hsp90-mediated removal of p-tau, while those of the mature Hsp90 refolding complex prevented this effect. This is the first demonstration to our knowledge that blockade of the refolding pathway promotes p-tau turnover through degradation. We also show that peripheral administration of a novel Hsp90 inhibitor promoted selective decreases in p-tau species in a mouse model of tauopathy, further suggesting a central role for the Hsp90 complex in the pathogenesis of tauopathies. When taken in the context of known high-affinity Hsp90 complexes in affected regions of the AD brain, these data implicate a central role for Hsp90 in the development of AD and other tauopathies and may provide a rationale for the development of novel Hsp90-based therapeutic strategies.
Alopecia areata associated with basal cell carcinoma developing within a naevus sebaceus
Authors: C.W. Choi, B.J. Kim, E.S. Park, C.H. Huh
Journal: British Journal of Dermatology (2006)

Journal Article Alopecia areata associated with basal cell carcinoma developing within a naevus sebaceus Get access C.W. Choi, C.W. Choi Department of Dermatology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumi‐dong, Bundang‐gu, Seongnam‐si, Kyounggi‐do 463–707, Korea *Department of Dermatology, Dongguk University International Hospital, Kyounggi‐do, Korea Search for other works by this author on: Oxford Academic Google Scholar B.J. Kim, B.J. Kim Department of Dermatology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumi‐dong, Bundang‐gu, Seongnam‐si, Kyounggi‐do 463–707, Korea *Department of Dermatology, Dongguk University International Hospital, Kyounggi‐do, Korea Search for other works by this author on: Oxford Academic Google Scholar E.S. Park, E.S. Park Department of Dermatology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumi‐dong, Bundang‐gu, Seongnam‐si, Kyounggi‐do 463–707, Korea *Department of Dermatology, Dongguk University International Hospital, Kyounggi‐do, Korea Search for other works by this author on: Oxford Academic Google Scholar C.H. Huh C.H. Huh Department of Dermatology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumi‐dong, Bundang‐gu, Seongnam‐si, Kyounggi‐do 463–707, Korea *Department of Dermatology, Dongguk University International Hospital, Kyounggi‐do, Korea Chang Hun Huh. E‐mail: chhuh@snu.ac.kr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 155, Issue 5, 1 November 2006, Pages 1090–1091, https://doi.org/10.1111/j.1365-2133.2006.07485.x Published: 01 November 2006
Prenatal Exposure with Aerosolized Allergen Prevents Subsequent Allergen-Induced Sensitization and Airway Inflammation in Young Mice
Authors: K. Gerhold, A. Avagyan, C. Seib, B. Ahrens, J. Jaworska, A. Dittrich, U. Wahn, E. Hamelmann
Journal: Journal of Allergy and Clinical Immunology (2006)
Percutaneous Valve-in-Valve Procedure for Severe Paravalvular Regurgitation in Aortic Bioprosthesis
Authors: Arnold C.T. Ng, Frank van der Kley, Victoria Delgado, Miriam Shanks, Rutger J. van Bommel, Arend de Weger, Giuseppe Tavilla, Eduard R. Holman, Joanne D. Schuijf, Nico R. van de Veire, Martin J. Schalij, Jeroen J. Bax
Journal: JACC. Cardiovascular imaging (2009)
The effect of peginterferon alfa-2a (40 KD) on liver histology in chronic hepatitis C: A meta-analysis of individual patients data
Authors: C. Camma, D. Di Bona, F. Schepis, E.J. Heathcote, S. Zeuzem, P.J. Pockros, P. Marcellin, A. Alberti, A. Craxi
Journal: Journal of Hepatology (2003)
Improving the Outcomes of Care for Patients with Human Immunodeficiency Virus Infection
Authors: Paul A. Volberding
Journal: New England Journal of Medicine (1996)

A wide spectrum of specialists and generalists are now delivering care of increasing complexity for patients infected with the human immunodeficiency virus (HIV). Few of these physicians have had any formal training in what is, in many respects, a new multidisciplinary medical specialty. Within health care organizations, there is often little coordination among practitioners who treat HIV-infected patients. In some systems, such patients are intentionally “mainstreamed” by assigning their care to generalists regardless of the experience or training of the physicians or their interest in this disease. When this happens, important recent advances in management may never reach the patients. . . .
Orthopaedic surgeons and thromboprophylaxis.
Authors: M D Laverick, S A Croal, R A Mollan
Journal: BMJ (1991)

OBJECTIVE--To assess attitudes to the use of thromboprophylaxis among orthopaedic surgeons in the United Kingdom. DESIGN AND SUBJECTS--Single page postal questionnaire to all 926 active orthopaedic surgeons who are members of the British Orthopaedic Association. RESULTS--The response rate was 70% (659 surgeons), of whom 595 (90%) used some form of prophylaxis. Most (548; 83%) used drugs but 47 (7%) used only elasticated stockings. A history of thromboembolic disease, hip surgery, and obesity was seen as the main risk factor. Ineffectiveness was the principal reason for not using prophylaxis. CONCLUSIONS--Most orthopaedic surgeons use regimens of thromboprophylaxis, though many of these are of limited value. Improvements in the efficacy and safety of prophylactic agents, combined with ease of administration, would increase the use of such agents and make orthopaedic surgery safer for the patient.