tbuckley/cabot-search huggingface dataset:
Anonychia, hyponychia and spontaneous amputation of the distal phalanges as a consequence of ischaemic necrosis of the extremities after umbilical catheterization
Authors: I. Neri, F. Savoia, F. Giacomini, A. Patrizi
Journal: British Journal of Dermatology (2007)

Journal Article Anonychia, hyponychia and spontaneous amputation of the distal phalanges as a consequence of ischaemic necrosis of the extremities after umbilical catheterization Get access I. Neri, I. Neri Department of Specialist and Experimental Clinical Medicine, Division of Dermatology, S. Orsola‐Malpighi Hospital, University of Bologna, via Massarenti 1 CAP 40138, Bologna, Italy E‐mail: iria.neri@tin.it Search for other works by this author on: Oxford Academic Google Scholar F. Savoia, F. Savoia Department of Specialist and Experimental Clinical Medicine, Division of Dermatology, S. Orsola‐Malpighi Hospital, University of Bologna, via Massarenti 1 CAP 40138, Bologna, Italy E‐mail: iria.neri@tin.it Search for other works by this author on: Oxford Academic Google Scholar F. Giacomini, F. Giacomini Department of Specialist and Experimental Clinical Medicine, Division of Dermatology, S. Orsola‐Malpighi Hospital, University of Bologna, via Massarenti 1 CAP 40138, Bologna, Italy E‐mail: iria.neri@tin.it Search for other works by this author on: Oxford Academic Google Scholar A. Patrizi A. Patrizi Department of Specialist and Experimental Clinical Medicine, Division of Dermatology, S. Orsola‐Malpighi Hospital, University of Bologna, via Massarenti 1 CAP 40138, Bologna, Italy E‐mail: iria.neri@tin.it Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 157, Issue 6, 1 December 2007, Pages 1299–1301, https://doi.org/10.1111/j.1365-2133.2007.08228.x Published: 01 December 2007
Intermittent Claudication
Authors: Joanne M. Murabito, Ralph B. D’Agostino, Halit Silbershatz, Peter W. F. Wilson
Journal: Circulation (1997)

Background Intermittent claudication identifies persons at increased risk for death and disability. Methods and Results Using 38-year follow-up data for the original cohort in the Framingham Heart Study, we developed an intermittent claudication risk profile. Intermittent claudication occurred in a total of 381 men and women. Age, sex, serum cholesterol, hypertension, cigarette smoking, diabetes, and coronary heart disease were associated with an increased risk for claudication and were included in the profile. A pooled logistic regression model was used to compute the probability of intermittent claudication for specified levels of risk factors. Conclusions The intermittent claudication risk profile allows physicians to identify high-risk individuals during a routine office visit and can be used to educate patients about modifiable risk factors, particularly smoking and blood pressure. Improved compliance with risk factor modification strategies may result in a beneficial impact on survival.
Matrix Metalloproteinase Activity Modulates Tumor Size, Cell Motility, and Cell Invasiveness in Murine Aggressive Fibromatosis
Authors: Yuan Kong, Raymond Poon, Puviindran Nadesan, Tamara Di Muccio, Riccardo Fodde, Rama Khokha, Benjamin A. Alman
Journal: Cancer Research (2004)

Abstract Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) regulate the degradation of extracellular matrix components and play important roles in the progression of select neoplastic processes. The locally invasive soft tissue tumor, aggressive fibromatosis (also called desmoid tumor), is caused by mutations resulting in β-catenin-mediated T-cell factor (tcf)-dependent transcriptional activity. Because β-catenin can regulate MMP expression, we investigated the expression of several MMPs and TIMPs in aggressive fibromatosis tumors that develop in Apc+/Apc1638N mice. Mmp-3 and Timp-1 were differentially regulated (5-fold and 0.5-fold, respectively) in tumors compared with normal fibrous tissue. Conditioned media from tumor cells showed an increased ability to degrade collagen, and inhibition of MMPs using GM6001 decreased the ability of the tumor cells to invade through Matrigel. Both the treatment of Apc/Apc1638N mice with GM6001 or crossing with a transgenic mouse that overexpresses Timp-1 resulted in a significant reduction in tumor volume. Surprisingly, overexpression of Timp-1 also resulted in a 50% increase in tumor number. Although TIMP-1 can induce growth stimulatory effects in some cell types, we found no difference in proliferation or apoptosis rate in cells from tumors that developed in the Timp-1–transgenic mice compared with mice that did not express the Timp-1 transgene, suggesting that TIMP-1 promotes aggressive fibromatosis tumor formation through an alternate mechanism. These data suggest that MMPs play a crucial role in regulating the invasiveness of mesenchymal cells and in modulating aggressive fibromatosis tumor progression. Because this is a locally invasive tumor, MMP inhibition could slow tumor growth and may prove to be an effective adjuvant therapy.
Composition of the Diet and Calcium Kidney Stones
Authors: Jacob Lemann
Journal: New England Journal of Medicine (1993)

Kidney stones occur frequently. As many as 10 percent of men and 3 percent of women have a stone during their adult lives1. About 80 percent of all stones are composed of calcium oxalate, alone or with a nucleus of calcium phosphate (apatite)1. The first step in the formation of calcium stones is the formation of microscopic crystals in the lumen of renal tubules as a result of supersaturation of the luminal fluid with calcium oxalate or calcium phosphate. Crystal growth, and therefore stone formation, is enhanced by the attachment of crystals to the surface of cells in . . .
Pressure in cuffed tubes.
Authors: W Norman-Taylor
Journal: BMJ (1979)

28 % oxygen, her PaO2 was 20-22 kPa and PaCO2 4-5 kPa.Prior to her return to the ward she was started on aminophylline suppositories 360 mg twice daily, prednisolone 20 mg twice daily, salbutamol, and becotide inhalers.Three days later she had three grand mal seizures within one hour, commencing on the right side of her body.Intravenous diazepam (10 mg) given after the first seizure did not prevent the two further attacks.Treatment with aminophylline suppositories was stopped and no further fits occurred.An electro- encephalogram on the following day was normal.In children, convulsions have followed the rectal administration of aminophylline,l but this effect has rarely been described in adults.Absorption from suppositories is unpre- dictable.2In adults convulsions have occurred following intravenous administration.:The patient described above was given 720 mg/day =0-8 mg aminophylline/kg/h for three days.It has been recommended that adults with severe asthma should be given no more than 1 g/day of aminophylline intravenously,4 or no more than 0-9 mg/kg/h.5This case illustrates the danger of aminophylline suppositories and prolonged treatment at high doses.We suggest that this drug should be prescribed by weight at specified intervals rather than in terms of the number of tablets or suppositories, particularly in small adults.
Persistent Infection by Trichophyton megninii in Leeds
Authors: R. M. Holman, C. J. Latouche
Journal: BMJ (1965)

Mml C" 303 said that she had swallowed her dental plate at about 2 p.m. the same day.She could feel it in her throat X-ray pictures were reported by a consultant radiologist " no foreign body is seen."On clinical examination it was obvious that the denture was impacted in the upper oesophagus.At oesophagoscopy at 5 p.m. the dental plate ._
Correction: Morality Hits the Dust
Authors: A. F. PERL
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 June 1972Correction: Morality Hits the DustA. F. PERL, M.D., F.A.C.P.A. F. PERL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-6-1047_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Shades of Sigmund Freud! It has been brought out that the border between public relation and pubic relations has been blurred—but what mortality has morality?... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 1944 Lakeshore Rd. Sarnia, Ontario, Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1972Volume 76, Issue 6Page: 1047-1048KeywordsDustMortality ePublished: 1 December 2008 Issue Published: 1 June 1972 PDF downloadLoading ...
Compartmentalized cytokine production within the human lung in unilateral pneumonia.
Authors: M S Dehoux, A Boutten, J Ostinelli, N Seta, M C Dombret, B Crestani, M Deschenes, J L Trouillet, M Aubier
Journal: American Journal of Respiratory and Critical Care Medicine (1994)

The in situ inflammatory response developing in the human lung during a localized bacterial infection was studied in 15 patients with unilateral community-acquired pneumonia (CAP). The local response in the involved lung was compared with that in the contralateral, noninvolved lung as well as with the systemic blood response. Eight healthy volunteers served as control subjects. Concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and interleukin-6 (IL-6) were measured by ELISA in bronchoalveolar lavage (BAL) fluids (n = 15), serum (n = 15), and alveolar macrophage and monocyte culture supernatants (n = 8). The concentrations of TNF-alpha, IL-beta and IL-6 in BAL fluid were significantly higher in the involved lung than in the paired noninvolved lung (p < or = 0.01) or in healthy subjects (p < or = 0.02, p < or = 0.01, and p < or = 0.001, respectively). Serum IL-6 concentrations were higher in patients than in control subjects, whereas IL-1 beta and TNF-alpha concentrations did not differ in the two groups. Alveolar macrophages from the involved lung spontaneously released higher concentrations of IL-1 beta, IL-6, and TNF-alpha (p < or = 0.05) than did macrophages from the noninvolved lung, which served as controls. However, macrophages were hyporesponsive in terms of cytokine production to further stimulation by lipopolysaccharide (LPS) in the noninvolved and involved lung compared with controls, whereas peripheral blood monocytes were not.(ABSTRACT TRUNCATED AT 250 WORDS)
PEI protected aptamer molecular probes for contrast-enhanced in vivo cancer imaging
Authors: Ping Gong, Bihua Shi, Mingbin Zheng, Bi Wang, Pengfei Zhang, Dehong Hu, Duyang Gao, Zonghai Sheng, Cuifang Zheng, Yifan Ma, Lintao Cai
Journal: Biomaterials (2012)
Acquired aplastic anemia: Antibody-mediated hematopoietic failure
Authors: Melvin H. Freedman, Erwin W. Gelfand, E. Fred Saunders
Journal: American Journal of Hematology (1979)

Abstract The hematopoietic failure in aplastic anemia was studied in six patients by assessing marrow erythroid stem cell (CFU‐E) and granulocytic stem cell (CFU‐C) colony growth in vitro. CFU‐E and CFU‐C were absent or reduced in five patients, and their serum did not inhibit CFU‐E or CFU‐C growth from control marrows. In contrast, marrow from one patient yielded 80 CFU‐E/10 5 and 16 CFU‐C/10 5 (control CFU‐E: 197/10 5 cells plated, range 110–387; control CFU‐C: 48/10 5 , range 15–106). His serum decreased CFU‐E (122 to 9/10 5 ) and CFU‐C (71 to 32/10 5 ) from control marrow, and CFU‐E from his own marrow (80 to 37/10 5 ). His peripheral blood lymphocytes cocultured with autologous or control marrow similarly decreased CFU‐C. The inhibition was more marked in cocultures using a B‐cell enriched lymphocyte fraction obtained by albumin density gradient centrifugation. IgG separated from the patient's serum demonstrated a dose‐responsive suppression of CFU‐E (102 to 8/10 5 ), and of CFU‐C (58 to 28/10 5 ) from control marrow. We conclude that of the six patients, one demonstrated an antibody‐mediated hematopoietic failure. It is recommended that all patients with acquired aplastic anemia be studied for this, since in vitro testing can detect those in whom immunosuppression and plasmapheresis may be more appropriate therapy than marrow transplantation.
THE PRESENCE OF DESQUAMATED ENDOTHELIAL CELLS, THE SO CALLED CLASMATOCYTES, IN NORMAL MAMMALIAN BLOOD
Authors: Florence R. Sabin, Charles A. Doan
Journal: The Journal of Experimental Medicine (1926)

1. There is a practically constant desquamation of endothelial cells into the circulating blood in rabbits and man. 2. These endothelial cells represent the entire range in size of endothelium from very small cells, possibly from capillaries, up to the type of the large Kupffer cell. 3. These desquamated cells can be discriminated from monocytes. 4. There are common morphological and functional characteristics among the following cells: the clasmatocytes from the specific endothelia, such as the cells from the sinuses of the liver, spleen, and bone marrow; the clasmatocytes of the diffuse connective tissues; and desquamated endothelial cells occurring in normal and pathological blood. 5. There are four strains of white cells in the normal circulating human and rabbit blood, granulocytes, lymphocytes, monocytes, and endothelial phagocytes.
Carcinoma in Situ of the Esophagus (Early Esophageal Cancer): A Case Report and a Review of the Literature
Authors: E. Seifert, H. Borst, H. Ostertag, H. Stender, M. Braschke, F. Misaki, Z. Atay
Journal: Endoscopy (1973)

A 66-year-old female presented with pains in swallowing solid foods and scraping behind the sternum. X-ray examination, esophagoscopy, guided biopsy and contact cytology indicated a squamous cell carcinoma in situ type II a. The diagnosis was confirmed by histological examination of the resected esophagus, which revealed that the cancerous infiltration was limited to the mucosa. The findings in our case were compared with reports in the literature. As in our cases published by Japanese authors, the combination of all known diagnostic methods is necessary in order to recognize an early stage of esophageal cancer; endoscopy with guided biopsy and cytology seem to be the most important procedures for detection. To our knowledge, the case reported in this paper is the first one outside of Japan which has been diagnosed correctly by X-ray, endoscopy, guided biopsy and contact cytology prior to operation.
Health Care Reform — A Republican View
Authors: Chuck Grassley
Journal: New England Journal of Medicine (2009)

The health care system has serious problems. Costs are rising at three times the inflation rate. Many Americans are uninsured. Millions more fear losing their insurance in a weak economy or because of preexisting conditions. Doctors are ready to close their doors because of high malpractice insurance costs and low government reimbursement rates.Everyone agrees that something has to be done. But the reform proposals pending in Congress would make a bad situation worse. These bills would cause us to slide rapidly down the slippery slope toward increasing government control of health care. They contain the biggest expansion of Medicaid . . .
Disruption of smooth pursuit eye movements in cirrhosis: Relationship to hepatic encephalopathy and its treatment
Authors: Sara Montagnese, Harriet M. Gordon, Clive Jackson, Justine Smith, Patrizia Tognella, Nutan Jethwa, Michael R. Sherratt, Marsha Y. Morgan
Journal: Hepatology (2005)

Abstract Smooth pursuit eye movements (SPEM) are the conjugate movements used to track the smooth trajectory of small dots. Jerky or ‘saccadic’ ocular pursuit has been reported in patients with cirrhosis, but no formal assessment of SPEM has ever been undertaken. The aim of this study was to evaluate SPEM in patients with cirrhosis and varying degrees of hepatic encephalopathy. The patient population comprised 56 individuals (31 men, 25 women) of mean age 51.1 (range, 25–70) years, with biopsy-proven cirrhosis, classified, using clinical, electroencephalographic, and psychometric variables, as either neuropsychiatrically unimpaired or as having minimal or overt hepatic encephalopathy; patients were further categorized in relation to their treatment status. The reference population comprised 28 healthy volunteers (12 men, 16 women) of mean age 47.3 (range, 26–65) years. SPEM was assessed using an electro-oculographic technique. Visual inspection of the SPEM recordings showed clear disruption of smooth pursuit in the patients with minimal hepatic encephalopathy, and more pronounced disruption, if not complete loss, of smooth pursuit in patients with overt hepatic encephalopathy. The differences observed in quantifiable SPEM indices between the healthy volunteers/unimpaired patients and those with overt hepatic encephalopathy were significant ( P &lt; .05). In conclusion , SPEM performance is impaired in patients with hepatic encephalopathy in parallel with the degree of neuropsychiatric disturbance: the pathophysiology of these changes is unknown, but retinal, extrapyramidal, and attentional abnormalities are likely to play a role. Treatment status confounds the classification of neuropsychiatric status and should be taken into account when categorizing these patients. (Hepatology 2005;42:772–781.)
To a Favorite Patient
Authors: Clayton J. Baker
Journal: Annals of Internal Medicine (2007)

Ad Libitum20 February 2007To a Favorite PatientClayton J. Baker, MDClayton J. Baker, MDFrom Pittsford, New York.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-4-200702200-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Ever since Iextracted, magician-like,that bulbous tick fromyour ear canal,dangled itat forceps' end, legs wigglingcrazily beforeyour leathered face,which lit upscreaming “Aiii-EEEE!” (Navajofor “YIKES!”, I guess), thenlaughed when I wrappedyour tormentorin gauze, set it on the tile floor,made you stomp itto tick heaven,and you re-donnedyour old silk shawl, knotted tight atthe jaw, coveringyour debugged ear,you kept allyour appointments faithfully,trusted my word, evencalled me your son. Author, Article, and Disclosure InformationAffiliations: From Pittsford, New York.Current Author Address: Clayton J. Baker, MD, 1919 Calkins Road, Pittsford, NY 14534. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 February 2007Volume 146, Issue 4Page: 316KeywordsTicks ePublished: 20 February 2007 Issue Published: 20 February 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 3530: OATP1B3 in pancreatic cancer tissue as a potential target for anticancer drug transport
Authors: Amanda Obaidat, Bruno Hagenbuch
Journal: Cancer Research (2010)

Abstract Organic Anion Transporting Polypeptides (OATPs) are multispecific transporters that are expressed in normal and cancerous tissue (e.g. colon, prostate, breast and bone cancers). Several anticancer drugs have been shown to be transported by certain OATPs. The aim of the study was to determine the expression of OATPs in pancreatic cancer tissue and functionally characterize anticancer drug transport via the expressed OATPs. Ten pancreas tissue samples were obtained for analysis: 6 normal pancreas, 3 pancreatic cancer and 1 metastatic tissue. Expression of OATPs was analyzed at the mRNA level using the Quantigene assay. Protein expression and localization were determined by immunofluorescence with OATP specific antibodies. Transport of the radiolabeled anticancer drugs paclitaxel and docetaxel was measured in an OATP-expressing Chinese Hamster Ovary (CHO) cell system. Among the 11 human OATPs, expression in pancreatic cancer tissue at the mRNA level was highest for OATP4A1 followed by OATP3A1, OATP2A1 and OATP1B3. Expression of OATP4A1, OATP3A1 and OATP1B3 was confirmed at the protein level. In addition, transport of paclitaxel and docetaxel was observed in OATP1B3-expressing CHO cells with Km values of 2.2 μM for both substrates. In summary, OATP4A1, OATP3A1 and OATP1B3 are expressed in pancreatic cancer. OATP1B3 transports the anticancer drugs paclitaxel and docetaxel with relatively high affinities. In conclusion, given that OATP1B3 is exclusively expressed in normal human hepatocytes, which are generally resistant to the effects of anticancer therapy, transport of anticancer drugs via this transporter might be a feasible approach to target the killing of OATP1B3-expressing cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3530.
Observations suggesting bioactive Fgf15 is not present in mouse blood
Authors: Mats Rudling
Journal: Gut (2013)

Observations suggesting bioactive Fgf15 is not present in mouse blood I read with interest the paper by Uriarte et al, 1 in which the authors conclude that 'Fgf15 is a key mediator of the liver growth-promoting effects of bile acids.'There are reasons to question the conclusions drawn in this paper.Due to space limit I forward three issues.(1) Fgf15 exerts its effects via FGFR4 as mentioned.The authors have not recognised a report by Yu et al 2 showing that deletion of FGFR4 does not alter the ability of the liver to regenerate after partial hepatectomy.How can circulating Fgf15 (derived from the gut as currently often believed, and as also these authors claim) be crucial for liver regeneration, when FGFR4 has no role in liver regeneration 2 ?This discrepancy strongly suggests that the inability of the liver to regenerate in Fgf15KO mice is independent of FGFR4, and by consequence, must be explained by FGFR4-independent actions.This, in turn, implies that changes in any circulating Fgf15 from gut to liver is highly unlikely to explain why liver regeneration in FGF15KO mice is impaired, provided that FGFR4 indeed is the receptor for Fgf15.One plausible explanation for this intriguing latter conclusion is that Fgf15 is simply not present in mouse or rat blood plasma, which is actually in line with previous and recent 3 failures to detect Fgf15 in rodent plasma.It must be remembered that the evidence for the presence of circulating Fgf15 are circumstantial, and that an alternative mechanism explaining 'Fgf15-caused' effects on bile acid synthesis was recently suggested 4 that is soon to be demonstrated.(2) In the introduction, the authors state that: 'After reaching the liver through the portal circulation, Fgf15 was shown to bind and activate the FGF receptor 4 (FGFR4)'.This statement is incorrect.The evidence for circulating Fgf15 are circumstantial, and the presence of circulating Fgf15 has never been shown, as mentioned presumably because it is not there.If authors have data on mouse plasma Fgf15, please indicate that.(3) Authors show that incubation of mouse hepatocytes with 50 and 100 ng/ml of FGF19 stimulates cell proliferation.In normal human plasma FGF19 averages