tbuckley/cabot-search huggingface dataset:
Life in the Shadow: Living With Cancer
Authors: John M. Merrill
Journal: JAMA (1991)

This is a story of a personal war and its multiple battles. The author's six bouts with Hodgkin's disease end with his holding a tenuous victory. Now, to the reader, this is not giving away the ending; you just know that this warrior is going to win. There is a real chronicle of therapy here. The author can legitimately query whether he is the most-treated Hodgkin's patient there is. Seemingly, every therapy works, yet nothing succeeds. The intermittent victories and defeats "... every therapy works, yet nothing succeeds." are woven in with the history of Hodgkin's disease and engaging anecdotes about famous victims and survivors. There is a clublike sense to much of this. The famous baseball player (Mickey Mantle) doesn't want to be a member, the famous Olympian (Jeff Blatnick) does, the famous television producer (Brandon Tartikoff) accepts "membership" only half the time but goes on to affect the cancer
Antibiotics and Gram-Negative Bacteremia
Authors: John E. McGowan
Journal: JAMA (1975)

<h3>To the Editor.—</h3> Some points in the recent article by Dr Curti (231:1361, 1975) deserve further comment. Dr Curti reviews evidence that incidence of, and survival from, Gramnegative bacteremia depend on more than antibiotic therapy. But this does not mean that misuse and overuse of antibiotics have not contributed to the increased prevalence of Gramnegative bacteremia, particularly when bloodstream invasion arises from nosocomial infection. If, as Dr Curti suggests, current treatment methods depress host resistance to the point that infection is likely, then when infection occurs, it is likely to be caused by whatever organisms are "around." In the hospital setting, frequent antibiotic usage facilitates the persistence of multiresistant organisms that are "tough" organisms to eradicate from the patient.<sup>1</sup>Reports in which discontinuance of antibiotic usage was successful in ending epidemic or endemic infection due to antibiotic-resistant organisms<sup>2,3</sup>suggest that many of these Gram-negative bacilli cannot predominate, or
Breast cancer and thoracic metastases: review of 119 patients.
Authors: H Kreisman, N Wolkove, H S Finkelstein, C Cohen, R Margolese, H Frank
Journal: Thorax (1983)

Review of the case notes of 660 patients with a diagnosis of breast cancer during a five-year period showed that in 119 cases there had been thoracic metastases. These were recorded as pleural or extrapleural metastases (79 patients), mediastinal tumour (46 patients), lymphangitic carcinoma (41 patients), pulmonary nodules (34 patients), and solitary pulmonary nodule (nine patients). Endobronchial metastases were present in seven patients and multiple pulmonary tumour emboli in two. The thorax was often the initial site of tumour recurrence. Most of these recurrences were present in several locations (intrathoracic or both intrathoracic and extrathoracic) simultaneously, facilitating the clinical diagnosis of metastatic breast cancer. Histopathological confirmation of metastasis was mandatory for the 10 patients who had a solitary intrathoracic abnormality without evidence of disease elsewhere. The median survival after diagnosis and treatment of a solitary thoracic metastasis was 42+ months and three of 10 patients are currently in remission (at 44, 87, and 121 months). The small tumour burden and early diagnosis giving lead time may explain the long survival in this group of patients.
Heart rate adjustment of ST segment depression for improved detection of coronary artery disease.
Authors: P Kligfield, O Ameisen, P M Okin
Journal: Circulation (1989)

Normal values for heart rate-adjusted indexes of ST segment depression during treadmill exercise electrocardiography (the ST segment/heart rate slope and the delta ST segment/heart rate index) were derived from evaluation of 150 subjects with a low likelihood of coronary artery disease, including 100 normal subjects and 50 subjects with nonanginal chest pain. Partitions chosen by the method of percentile estimation to include 95% of normal subjects remained highly specific in subjects with nonanginal pain syndromes. Sensitivities of the derived partitions for detection of myocardial ischemia were tested in an additional 150 patients with a high likelihood of coronary disease, including 100 patients with angiographically demonstrated coronary obstruction and 50 patients with stable angina. In contrast to the 68% (102 of 150 subjects) sensitivity of standard exercise electrocardiographic criteria for the detection of disease in this population, the sensitivity of an ST segment/heart rate slope partition of 2.4 muV/beats/min was 95% (142 of 150 subjects, p less than 0.001), and the sensitivity of a delta ST segment/heart rate index partition of 1.6 muV/beats/min was 91% (137 of 150 subjects, p less than 0.001). Analysis of receiver-operating curves confirmed the superior performance of the heart rate-adjusted indexes throughout a wide range of test specificities. These findings suggest that heart rate adjustment of ST segment depression can markedly improve the clinical usefulness of the treadmill exercise electrocardiogram.
Understanding Sexual Violence Perpetration
Authors: William H. Goodson
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Methods for Serum-Free Culture of Epithelial and Fibroblastic Cells. Edited by David W. Barnes, David A. Sirbasku and Gordon H. Sato (Cell Culture Methods for Molecular and Cell Biology, Vol. 3). 291 pp + xx. New York: Alan R. Liss, 1984. $49.50
Authors: Montgomery D. Bissell
Journal: Hepatology (1985)
TOLERANCE OF THE TISSUES TO FOREIGN BODIESWITH SPECIAL REFERENCE TO THE PULP AND GUMS.
Authors: M. H. FLETCHER
Journal: JAMA (1904)

The reason that one foreign substance within the tissues is more or less irritating than another, is to be determined not alone by the character of the substance but also by how it influences the cells of the tissues involved. That environment influences cell life is well known. Aside from the effect of their food, cells may be influenced by temperature, electrically, by chemicals and mechanically. Our present purpose is to consider mechanical irritants. In treatises on gunshot wounds it is presumed that the bullet is of lead, and the practice almost universally advised is to leave the ball undisturbed if it is not easily found. There is an adage generally recognized to the effect that "when a bullet has ceased to move it has ceased to do harm." The accompanying specimens (Figs. 1 and 2) of elephant's tusks, No. 1 with a lead bullet encapsulated, No. 2 with an
Gentamicin- and silver-resistant pseudomonas in a burns unit.
Authors: K Bridges, A Kidson, E J Lowbury, M D Wilkins
Journal: BMJ (1979)

In 1977-8 gentamicin-resistant strains of Pseudomonas aeruginosa became very common in a burns unit, over 90% being resistant at the peak of the outbreak. Some strains were also resistant to silver nitrate, though silver resistance was not found in any other strains of Ps aeruginosa isolated. Unlike the gentamicin resistance, the silver resistance was unstable, and strains became sensitive on repeated subculture. All the gentamicin-resistant strains of Ps aeruginosa were of the same serotype (O:11, H:2,5). Though gentamicin resistance could be transferred in vitro from resistant strains of Ps aeruginosa to one sensitive strain of Ps aeruginosa, there was no evidence of in-vivo transfer of gentamicin resistance between strains of pseudomonas in the patients' burns, nor was there evidence of transfer of gentamicin resistance between Ps aeruginosa and enterobacteria. Carbenicillin-resistant and gentamicin-resistant Ps aeruginosa were sometimes found in the same burns, but no gentamicin-carbenicillin (doubly) resistant strains were found among the 986 strains tested during the outbreak. The outbreak of gentamicin-resistant Ps aeruginosa from burns was not reduced by stopping treatment with gentamicin and its analogues but only by segregating all patients with Ps aeruginosa in one of the two wards of the unit and admitting new patients only to the other ward.
Disorders of the Heart and Circulation
Authors: Robert L. Levy
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
General practitioner outpatient referrals.
Authors: T R Howard
Journal: BMJ (1991)

despite a second reminder letter being sent.Our practice is centred on several large council estates, though appreciable numbers of patients live in relatively more affluent areas towards the periphery.The mammography caravan was sited 2-5 km from the heart of the practice area with reasonably direct public transport.One hundred and fifteen of the non-attenders live in the council estates, indicating that this screening programme is having its least impact on the poorer women in our practice.Also of great concern, however, is that overall attendance rates are well below the 70% expected and the hoped for 25% reduction in mortality from breast cancer is thus unlikely to be achieved.The screening programme has been organised at district level, and we have gained the impression that for many women it is seen as separate and distant from other forms ofprevention offered by general practice and primary care.If the government wishes to see more equitable screening coverage increased resources may need to be given to promoting the campaign at a more local level using existing networks of health education and health promotion in general practice.
POTENTIAL IMPACT OF PREDICTIVE MODELS FOR EARLY DETECTION OF HEART FAILURE ON THE INITIATION OF EVIDENCE-BASED THERAPIES
Authors: Rajakrishnan VHavakrishnan, Steven R. Steinhubl, Jimeng Sun, Roy J. Byrd, Zahra Daar, Jason Thompson, Shahram Ebadollahi, Walter F. Stewart
Journal: Journal of the American College of Cardiology (2012)
RELATIONSHIP BETWEEN LIPOPROTEIN(A), HOMOCYSTEINE, AND C-REACTIVE PROTEIN AND METABOLIC SYNDROME IN SOUTH ASIAN PATIENTS
Authors: Monica S. Divakaruni, Elena Flowers, Cesar Molina, Ashish Mathur, Megha Prasad, Leslie Abrams, Anita Sathe, Donna Malhotra, Ruby Basra, Gayatri Ratnam, Bradley E. Aouizerat, Mintu P. Turakhia
Journal: Journal of the American College of Cardiology (2010)
The Mitochondrial Genome of the Gymnosperm Cycas taitungensis Contains a Novel Family of Short Interspersed Elements, Bpu Sequences, and Abundant RNA Editing Sites
Authors: S.-M. Chaw, A. Chun-Chieh Shih, D. Wang, Y.-W. Wu, S.-M. Liu, T.-Y. Chou
Journal: Molecular Biology and Evolution (2008)

The mtDNA of Cycas taitungensis is a circular molecule of 414,903 bp, making it 2- to 6-fold larger than the known mtDNAs of charophytes and bryophytes, but similar to the average of 7 elucidated angiosperm mtDNAs. It is characterized by abundant RNA editing sites (1,084), more than twice the number found in the angiosperm mtDNAs. The A + T content of Cycas mtDNA is 53.1%, the lowest among known land plants. About 5% of the Cycas mtDNA is composed of a novel family of mobile elements, which we designated as "Bpu sequences." They share a consensus sequence of 36 bp with 2 terminal direct repeats (AAGG) and a recognition site for the Bpu 10I restriction endonuclease (CCTGAAGC). Comparison of the Cycas mtDNA with other plant mtDNAs revealed many new insights into the biology and evolution of land plant mtDNAs. For example, the noncoding sequences in mtDNAs have drastically expanded as land plants have evolved, with abrupt increases appearing in the bryophytes, and then in the seed plants. As a result, the genomic organizations of seed plant mtDNAs are much less compact than in other plants. Also, the Cycas mtDNA appears to have been exempted from the frequent gene loss observed in angiosperm mtDNAs. Similar to the angiosperms, the 3 Cycas genes nad1, nad2, and nad5 are disrupted by 5 group II intron squences, which have brought the genes into trans-splicing arrangements. The evolutionary origin and invasion/duplication mechanism of the Bpu sequences in Cycas mtDNA are hypothesized and discussed.
Role of alloantigens in natural killing. Allogeneic but not autologous tumor biopsy cells are sensitive for interferon-induced cytotoxicity of human blood lymphcoytes.
Authors: F T Vánky, S A Argov, S A Einhorn, E Klein
Journal: The Journal of Experimental Medicine (1980)

Blood lymphocytes of patients with solid tumors were assayed for cytotoxicity against autologous and allogeneic primary tumor cells. The lymphocytes killed autologous tumor cells in 7 of 25 cases (28%) and allogeneic tumor cells in 2 of 37 tests (5%). Lymphocytes from healthy donors were rarely cytotoxic for the biopsy cells, which indicates that these cells have low natural kill sensitivity. The autoreactivity that may reflect the immunological recognition of tumor cells was not altered by pretreatment of the effectors with interferon (IF). In contrast, killing of allogeneic tumor biopsy cells was induced by IF in approximately 50% of tests, with the lymphocytes of both the tumor patients and the healthy donors. The mechanism of the alloreactivity is most likely a consequence of IF-induced polyclonal activation of cytotoxic potential and the lymphocytes that are committed to recognize the alloantigens expressed on the particular target manifest the killing function. When the biopsy cells were explanted and kept in culture for 5-6 d, their susceptibility for the lymphocyte damage increased, and they were killed by the IF-treated cells also in autologous combinations. Whether this change in sensitivity is a result of qualitative or quantitative changes in antigen expression or of other changes in the properties of the cell membrane is unknown.
Novel Antiplatelet Drug Revacept (Dimeric Glycoprotein VI-Fc) Specifically and Efficiently Inhibited Collagen-Induced Platelet Aggregation Without Affecting General Hemostasis in Humans
Authors: Martin Ungerer, Kai Rosport, Andreas Bültmann, Richard Piechatzek, Kerstin Uhland, Peter Schlieper, Meinrad Gawaz, Götz Münch
Journal: Circulation (2011)

Blocking of glycoprotein VI-dependent pathways by interfering in vascular collagen sites is commonly seen as an attractive target for an antiplatelet therapy of acute atherosclerotic diseases such as myocardial infarction or stroke. Revacept (soluble dimeric glycoprotein VI-Fc fusion protein) has been shown to reduce platelet adhesion by blocking vascular collagen in plaques or erosion and to be safe in preclinical studies. A dose-escalating clinical phase I study was performed to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of Revacept in humans.In a first-in-humans study, 30 healthy men received a single intravenous administration of 10, 20, 40, 80, or 160 mg Revacept. The serum concentration-time courses of each dosage of Revacept showed a narrow variation and a concentration and time dependence. Revacept did not significantly affect the bleeding time. Collagen-induced platelet aggregation was dose-dependently inhibited up to 48 hours at lower doses and for 7 days after higher dose levels. In contrast, ADP- or thrombin receptor activating peptide-dependent platelet aggregation remained unaltered. There were no relevant drug-related adverse events or drug-related changes in laboratory parameters (biochemistry, hematology, and coagulation parameters). There were no drug-related changes in blood pressure, pulse rate, or ECG parameters (including 24-hour Holter monitoring). No anti-Revacept antibodies were detected.This phase I study demonstrated that Revacept is a safe and well-tolerated new antiplatelet compound with a clear dose-dependent pharmacokinetic profile with specific, dose-related inhibition of platelet aggregation despite completely unaltered general hemostasis.URL: www.clinicaltrials.gov. Unique identifier: NCT 01042964. URL: eudract.ema.europa.eu. Identifier: 2005-004656-12.
Donor cell leukemia in a patient developing 11 months after an allogeneic bone marrow transplantation for chronic myeloid leukemia
Authors: Selmin Ataergin, Fikret Arpaci, Turker Cetin, Sefik Guran, Cengiz Yakicier, Murat Beyzadeoglu, Ahmet Ozet
Journal: American Journal of Hematology (2006)

Abstract A 38‐year‐old female with chronic myeloid leukemia underwent an allogeneic bone marrow transplantation from her full‐matched brother. Eleven months later, she readmitted with an acute leukemia that was shown to be of donor origin. The patient never achieved a remission even after chemotherapies with cytarabine and mitoxantrone, donor lymphocyte infusion, and second allogeneic peripheral blood stem cell transplantation. Donor cell leukemia (DCL) is sometimes misdiagnosed as relapse by clinicians and the real incidence may be higher than expected. Cytogenetic and molecular techniques may be helpful to clarify the issue of the leukemia. The current case is another case of DCL reported in the literature after an allogeneic transplant for a kind of leukemia. Am. J. Hematol. 81:370–373, 2006
Reporting of blood pressure data in medical journals.
Authors: A Lehane, E T O'Brien, K O'Malley
Journal: BMJ (1980)

Acute renal failure precipitated by radiographic contrast medium in a patient with rhabdomyolysis Myoglobinuria is an uncommon but important cause of acute tubular necrosis.'It was originally described in association with trauma but also occurs in cases of non-traumatic rhabdomyolysis, when diagnosis may be more difficult.2'Infusion intravenous urography is a standard investigation for acute renal impairment of obscure cause1; we report a case of acute renal failure precipitated by administration of radio- graphic contrast medium in a patient with undiagnosed rhabdomyolysis and renal impairment. Case reportA 57-year-old man presented with malaise and fever.His history was not helpful, but he mentioned that his urine was the colour of "oxtail soup."Biochemical data were: sodium 134 mmol(mEq)/l, potassium 4-3 mmol virus inclusion bodies were present in the alveolar spaces.
A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy.
Authors: J C Tardiff, S M Factor, B D Tompkins, T E Hewett, B M Palmer, R L Moore, S Schwartz, J Robbins, L A Leinwand
Journal: Journal of Clinical Investigation (1998)

Mutations in multiple cardiac sarcomeric proteins including myosin heavy chain (MyHC) and cardiac troponin T (cTnT) cause a dominant genetic heart disease, familial hypertrophic cardiomyopathy (FHC). Patients with mutations in these two genes have quite distinct clinical characteristics. Those with MyHC mutations demonstrate more significant and uniform cardiac hypertrophy and a variable frequency of sudden death. Patients with cTnT mutations generally exhibit mild or no hypertrophy, but a high frequency of sudden death at an early age. To understand the basis for these distinctions and to study the pathogenesis of the disease, we have created transgenic mice expressing a truncated mouse cTnT allele analogous to one found in FHC patients. Mice expressing truncated cTnT at low (< 5%) levels develop cardiomyopathy and their hearts are significantly smaller (18-27%) than wild type. These animals also exhibit significant diastolic dysfunction and milder systolic dysfunction. Animals that express higher levels of transgene protein die within 24 h of birth. Transgenic mouse hearts demonstrate myocellular disarray and have a reduced number of cardiac myocytes that are smaller in size. These studies suggest that multiple cellular mechanisms result in the human disease, which is generally characterized by mild hypertrophy, but, also, frequent sudden death.
Functional CD40 ligand is expressed by T cells in rheumatoid arthritis.
Authors: K P MacDonald, Y Nishioka, P E Lipsky, R Thomas
Journal: Journal of Clinical Investigation (1997)

CD40 ligand (CD40-L), a member of the tumor necrosis family of transmembrane glycoproteins, is rapidly and transiently expressed on the surface of recently activated CD4+ T cells. Interactions between CD40-L and CD40 induce B cell immunoglobulin production as well as monocyte activation and dendritic cell differentiation. Since these features characterize rheumatoid arthritis (RA), the expression and function of CD40-L in RA was examined. Freshly isolated RA peripheral blood (PB) and synovial fluid (SF) T cells expressed CD40-L mRNA as well as low level cell surface CD40-L. An additional subset of CD4+ RA SF T cells upregulated cell surface CD40-L expression within 15 min of in vitro activation even in the presence of cycloheximide, but soluble CD40-L was not found in SF. CD40-L expressed by RA T cells was functional, since RA PB and SF T cells but not normal PB T cells stimulated CD40-L-dependent B cell immunoglobulin production and dendritic cell IL-12 expression in the absence of prolonged in vitro T cell activation. In view of the diverse proinflammatory effects of CD40-L, this molecule is likely to play a central role in the perpetuation of rheumatoid synovitis. Of importance, blockade of CD40-L may prove highly effective as a disease modifying therapy for RA.
Gradient reduction and aortic insufficiency and prolapse after ballon aortic valvuloplasty in 32
Authors: Robert E. Shaddy, Mark M. Boucek, Jane E. Sturtvant, Hertart D. Ruttenberg, L. Veassy, Vickl E. Judd, Garth S. Orsmond
Journal: Journal of the American College of Cardiology (1990)