tbuckley/cabot-search huggingface dataset:
Expanding the Boundaries of PTSD Treatment
Authors: Lisa M. Najavits
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Managing Potential Conflicts of Interest in State Medicaid Pharmacy and Therapeutics Committees: Seeking Harmony
Authors: Nirav Shah
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Osteopontin: a new addition to the constellation of cytokines which drive T helper cell type 1 responses in Crohn's disease
Authors: J N Gordon
Journal: Gut (2005)

Osteopontin, a cytokine which promotes Th1 immune responses, is overexpressed in the gut of patients with Crohn’s disease or ulcerative colitis. The main cellular source of this cytokine appears to be gut plasma cells.

Crohn’s disease appears to be caused by an excessive CD4+ T helper cell type I response directed against undefined antigens of the commensal bacterial flora.1 T cells from affected areas of Crohn’s disease mucosa produce enhanced amounts of interferon γ (IFN-γ) and tumour necrosis factor α. Other markers of Th1 cells, such as expression of the transcription factor T-bet, the high affinity β2 chain of the interleukin 12 (IL-12) receptor, and activated STAT4, all indicate that the mucosal environment in Crohn’s disease favours Th1 polarisation.1

It is important to emphasise that CD4 T cells in normal bowel are also Th1 skewed and express T-bet, so that the differences seen in Crohn’s disease are quantitative rather than qualitative.2 Normal mucosal T cells are however susceptible to apoptosis, whereas this is not the case in Crohn’s disease,3 suggesting that it is the persistence and accumulation of Th1 cells which drives tissue injury.

Factors which commit virgin T cells to the Th1 or Th2 pathway are still under investigation. T-bet appears to be of primary importance.4 It is induced by IFN-γ itself and is capable of promoting IFN-γ production, not only in Th1 cells, but also in Th2 cells. T-bet also increases expression of the IL-12Rβ2 chain. Macrophage and dendritic cell derived IL-12 is crucial in Th1 immune responses.5 The …
Amyotrophic Lateral Sclerosis: Recent Research Trends
Authors: Donald W. Mulder
Journal: JAMA (1977)

This book reports current research that may be important for understanding the etiology and therapy of amyotrophic lateral sclerosis (ALS). It is not meant as a review of what is known about ALS, and the reader will find very little to aid his understanding of the clinical disorder. The book focuses on the anterior horn cell of the spinal cord. The strength of the book is the excellent description of their own researches by investigators engaged in understanding the physiology and pathology of these cells. This, combined with an excellent bibliography, will be of great help to investigators who are studying or planning studies of the basic pathophysiology of amyotrophic lateral sclerosis. The initial chapters include an excellent review of the structural substrate of protein synthesis in the neurons as well as a discussion of the axonal transport systems. Motor neuron physiology and chemistry are discussed as they may possibly
PERIPROCEDURAL AND LONG TERM SAFETY AND FEASIBILITY OF TREATMENT WITH NOVEL ORAL ANTICOAGULANTS IN PATIENTS WITH BIOLOGICAL VALVE AND ATRIAL FIBRILLATION
Authors: Luigi Di Biase, Chintan Trivedi, Prasant Mohanty, Sanghamitra Mohanty, Carola Gianni, Rong Bai, Pasquale Santangeli, Javier Sanchez, Rodney Horton, Patrick Hranitzky, G. Gallinghouse, Amin Al-Ahmad, Jason Zagrodzky, Richard Hongo, Steven Hao, Salwa Beheiry, Dhanunjaya Lakkireddy, Madhu Reddy, Juan Viles-Gonzalez, John Burkhardt, Andrea Natale
Journal: Journal of the American College of Cardiology (2015)
Effects of Alcohol on the Electrocardiogram
Authors: GEORGE SERENY
Journal: Circulation (1971)

The electrocardiograms of 1,000 chronic alcoholic patients were examined and analyzed. Evidence is presented that excessive consumption of alcohol, in the absence of organic heart disease, may produce changes in the electrocardiogram. The predominant abnormalities were sinus tachycardia and nonspecific T-wave changes. These abnormalities were present in the majority of the patients, provided that electrocardiograms were taken while the patients were still intoxicated. It is suggested that the changes are caused by two known effects of alcohol: stimulation of catecholamine secretion from the adrenal medulla and alteration of cell membrane permeability.
Abstract OT3-3-03: Silent risk? Cardiovascular risk factors in survivors of breast cancer treated with anthracyclines.
Authors: Gillian Murtagh, Tomas G Lyons, Lucy Geraghty, Carmel Conlon, Elaine M Tallon, Jo Ballot, Anil Patel, Mallikarjuna Badabhagni, Mark T Ledwidge, David Fennelly, Giuseppe Gullo, Janice Walshe, John Crown, Kenneth M McDonald
Journal: Cancer Research (2012)

Abstract Withdrawn by Author Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr OT3-3-03.
More than 400 000 NHS staff sign up to "Hello, my name is" campaign
Authors: Z. Kmietowicz
Journal: BMJ (2015)

The “Hello, my name is…” campaign (hellomynameis.org.uk), in which NHS staff are encouraged to introduce themselves to patients, is being supported by over 80 NHS organisations in England, Wales, and Scotland and by more than 400 000 doctors, nurses, receptionists, and porters.

Kate Granger, 33, is an acting consultant in geriatric medicine at Mid Yorkshire Hospitals NHS Trust who launched the campaign after being treated for …
Insect stings--a medical emergency
Authors: C. A. Frazier
Journal: JAMA (1976)

EVERY summer, especially during the month of August, a large number of people are endangered by the teeming world of insects. This is not a case of blind guides, which strain at a gnat, and swallow a camel, for a generalized systemic reaction to a single insect sting can present a medical emergency that can result in death within 10 to 15 minutes. Since it is estimated that eight in a thousand individuals are allergic to insects and that four of these eight are severely sensitive, the potential for trouble is great. In fact, there are more fatalities annually due to insect stings or bites than to snakebites.  While some people do react allergically to the various flies, mosquitoes, biting midges, wheelbugs, and the like, members of the Hymenoptera order—bees, yellow jackets, hornets, wasps, and ants—are responsible for the more serious problems.  SYMPTOMS OF GENERALIZED SYSTEMIC REACTION  Symptoms of a
Thrombolytic treatment for recurrent myocardial infarction.
Authors: N J Dudley, E Burns
Journal: BMJ (1991)

TABLE Iv-British regional heart study.Characteristics at screening of men in different categories ofmilk intake Level of activity Recall doctors' diagnosis Drinking Current Serum total Systolic blood Age Manual smokers Obese* cholesterol pressure Inactive Vigorous Ischaemic heart Diabetes Non-
Protective Factors May Prevent Alcoholism
Authors: Bridget M. Kuehn
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
External committee is to look at criticisms of WHO's management of H1N1 pandemic
Authors: J. Zarocostas
Journal: BMJ (2010)

An evaluation of the World Health Organization’s management of the H1N1 swine flu pandemic will include an examination of the criticisms levelled at the agency, an interim report by an external expert review committee says.

The review of WHO’s role in the pandemic will include preparedness and planning; disease surveillance and epidemiology; risk assessment; communications; technical support for outbreak response; drug development and access; resource mobilisation, and coordination.

The interim report by the 29 member review committee on the functioning of the 2005 International Health Regulations in relation to the pandemic says it will also examine the work of the relevant expert committees, advisory groups, and other scientific groups providing advice to WHO. The “appropriateness of recommendations made by WHO as a result …
Self and Other in Schizophrenia: A Cognitive Neuroscience Perspective
Authors: Melissa Fisher, Kelly McCoy, John H. Poole, Sophia Vinogradov
Journal: American Journal of Psychiatry (2008)

Objective: Recent basic science data indicate that in healthy individuals, self-referential processing and social cognition rely on common neural substrates. The authors assessed self-referential source memory and social cognition in a large sample of schizophrenia outpatients and healthy comparison subjects in order to compare how these critical processes are associated in the two groups. Method: Ninety-one schizophrenia outpatients and 30 healthy comparison subjects were assessed on measures of basic social cognition and source memory for previously learned word items: self-generated, externally presented, and new words. Partial correlations and multiple regression analysis were used to test the association between social cognition measures and source memory performance and the contributions of source memory and general cognitive abilities to a social cognition composite score. Results: Schizophrenia patients demonstrated significantly lower source memory for self-generated items (self-referential source memory) relative to comparison subjects but showed intact external source memory. In both groups, self-referential source memory and social cognition showed strong correlations. When the effects of general cognitive abilities were controlled for, these correlations were attenuated in the schizophrenia patients. Regression analysis revealed discrepancies between groups in the cognitive functions contributing to social cognition performance. Conclusions: Impaired self-referential source memory represents a unique cognitive deficit in schizophrenia. Moreover, the strong association between self-referential source memory and social cognition seen in healthy subjects is reduced in schizophrenia and is moderated by general cognitive abilities. Impairments in the neurocognitive system that underlies both self-referential and social cognition provide a parsimonious explanation for the disturbances in the sense of self and other that characterize schizophrenia.
Randomized Comparison of Coronary Stenting With Balloon Angioplasty in Selected Patients With Acute Myocardial Infarction
Authors: Harry Suryapranata, Arnoud W. J. van’t Hof, Jan C. A. Hoorntje, Menko-Jan de Boer, Felix Zijlstra
Journal: Circulation (1998)

Background —Although the benefits of primary angioplasty in acute myocardial infarction have been demonstrated, several areas for improvement remain. Therefore, a prospective randomized trial comparing primary stenting with balloon angioplasty in patients with acute myocardial infarction was conducted. Methods and Results —Patients with acute myocardial infarction were randomly assigned to undergo either primary stenting (n=112) or balloon angioplasty (n=115). The clinical end points were death, recurrent infarction, subsequent bypass surgery, or repeat angioplasty of the infarct-related vessel. The overall mortality rate at 6 months was 2%. Recurrent infarction occurred in 8 patients (7%) after balloon angioplasty and in 1 (1%) after stenting ( P =0.036). Subsequent target-vessel revascularization was necessary in 19 (17%) and 4 (4%) patients, respectively ( P =0.0016). The cardiac event-free survival rate in the stent group was significantly higher than in the balloon angioplasty group (95% versus 80%; P =0.012). Conclusions —In selected patients with acute myocardial infarction, primary stenting can be applied safely and effectively, resulting in a lower incidence of recurrent infarction and a significant reduction in the need for subsequent target-vessel revascularization compared with balloon angioplasty.
A randomized controlled trial comparing standard- and low-dose strategies for transfusion of platelets (SToP) to patients with thrombocytopenia
Authors: Nancy M. Heddle, Richard J. Cook, Alan Tinmouth, C. Tom Kouroukis, Tor Hervig, Ellen Klapper, Joseph M. Brandwein, Zbigniew M. Szczepiorkowski, James P. AuBuchon, Rebecca L. Barty, Ker-Ai Lee
Journal: Blood (2008)
Injuries of the Brain and Spinal Cord and Their Coverings
Authors: H. R. Oberhill
Journal: JAMA (1960)

This fourth edition, like its predecessors, is comprehensive and detailed in its scope and should well serve as a guide for the clinician, teacher, and serious student alike in understanding fully the various facets of injuries of the central nervous system. Ably edited and directed by Dr. Brock, this product of some 32 contributing authors leaves little if anything uncovered with regard to the subject as known to date. Acute trauma in adults and children, including birth injuries of the central nervous system; the pathological and radiological aspects of such trauma; the complications, immediate and ultimate; and some aspects generally unrealized, are thoroughly considered. Post-traumatic psychoses, neuroses, convulsive disorders, and even malingering in relation to the general subject are presented in a sensible, competent, and practical evaluation. New chapters have been added, and these deal with post-traumatic infections including meningitis and cystitis and related complications in the paraplegic; pathological aspects
Should C-Reactive Protein Be Added to Metabolic Syndrome and to Assessment of Global Cardiovascular Risk?
Authors: Paul M Ridker, Peter W.F. Wilson, Scott M. Grundy
Journal: Circulation (2004)

Of novel risk factors for cardiovascular disease currently under investigation, high-sensitivity C-reactive protein (hsCRP) is the most promising. To date, more than 20 prospective epidemiologic studies have demonstrated that hsCRP independently predicts vascular risk, 6 cohort studies have confirmed that hsCRP evaluation adds prognostic information beyond that available from the Framingham Risk Score, and 8 cohort studies have demonstrated additive prognostic value at all levels of metabolic syndrome or in the prediction of type 2 diabetes. In contrast to several other biomarkers that also reflect biological aspects of inflammation, hypofibrinolysis, and insulin resistance, hsCRP measurement is inexpensive, standardized, widely available, and has a decade-to-decade variation similar to that of cholesterol. Given the consistency of prognostic data for hsCRP and the practicality of its use in outpatient clinical settings, we believe the time has come for a careful consideration of adding hsCRP as a clinical criterion for metabolic syndrome and for the creation of an hsCRP-modified coronary risk score useful for global risk prediction in both men and women. Toward this end, we believe experts in the fields of epidemiology, prevention, vascular biology, and clinical cardiology should be convened to begin discussing the merits of this proposal.
Library for Internists
Authors: LAWRENCE BRENNER
Journal: Annals of Internal Medicine (1974)

Comments and Corrections1 February 1974Library for InternistsLAWRENCE BRENNERLAWRENCE BRENNERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-2-284_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article, "A Library for Internists," by Allyn and Stearns (Ann Intern Med 79:293-322, 1973), will aid the individual who is not self-selective. I cannot believe that reading habits, with hundreds of like and dislike factors, should influence everyone. "What's good for me is good for you." Stearns has done this before with selections for community hospitals, with some criticism coming from the entire country on titles omitted (N Engl J Med 280:1188, 1969).It is odd that the Annals of Surgery made the list whileMedicine(Baltimore) did not. What happened toActa Medica Scandinavicaand... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston City Hospital Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1974Volume 80, Issue 2Page: 284-284KeywordsHabitsLibrariesSurgery Issue Published: 1 February 1974 PDF DownloadLoading ...
Relation of Cytogenetic Abnormalities and Clinical Outcome in Metastatic Melanoma
Authors: Jeffrey M. Trent, Frank L. Meyskens, Sydney E. Salmon, Kay Ryschon, Stanley P.L. Leong, John R. Davis, Daniel L. McGee
Journal: New England Journal of Medicine (1990)

The value of chromosomal analysis is well established in human hematologic neoplasms. In contrast, the relation between chromosomal abnormalities and clinical outcome in solid tumors in humans has received little study. We undertook this study to determine whether chromosomal abnormalities could provide information on the survival of patients with malignant melanoma. Chromosome-banding analysis was performed on tumor-biopsy samples from 62 patients with metastatic melanoma, and recurring cytogenetic abnormalities were correlated with survival. Patients with structural abnormalities of chromosome 7 or 11 had significantly shorter survival than patients without these abnormalities. We conclude that cytogenetic analysis may provide useful prognostic information about patients with metastatic melanoma.
Managed Care and Capitation in California: How Do Physicians at Financial Risk Control Their Own Utilization?
Authors: Eve A. Kerr
Journal: Annals of Internal Medicine (1995)

To describe the structure and range of utilization management methods initiated by physicians in response to capitation.Cross-sectional questionnaire.A large network-model health maintenance organization (133 contracting physician groups) in California.94 (71%) physician groups caring for 2.9 million capitated patients.Self-reported use of five major utilization management methods.All physician groups reported using gate-keeping and preauthorization for certain referrals or tests. Most also used profiling of utilization patterns (79%), guidelines (70%), and managed care education (69%). Most physician groups asked gatekeepers to submit preauthorization requests for specialty referrals and restricted patient self-referral. For example, 60% of groups required preauthorization for an internal medicine subspecialty referral, and 7% allowed patient self-referral. Most groups also asked gatekeepers to obtain preauthorization for many tests (for example, 95% for magnetic resonance imaging and 53% for pulmonary function tests). Preauthorization requests were denied infrequently (less than 10% of the time) by more than 75% of groups. Of the 54 groups reporting utilization profiles to their physicians, 61% never adjusted for case-mix among patients and more than 60% suggested practice changes to their physicians based on utilization. Fewer than 35% of the groups used written guidelines for expensive tests that required preauthorization (such as angiography).Physicians are responding to capitation by using utilization management techniques, some at early stages of development, that were previously used only by insurers. This physician-initiated management approach represents a fundamental transformation in the practice of medicine.