tbuckley/cabot-search huggingface dataset:
Lymphomatoid gastropathy: a distinct clinicopathologic entity of self-limited pseudomalignant NK-cell proliferation
Authors: Kengo Takeuchi, Masahiro Yokoyama, Shin Ishizawa, Yasuhito Terui, Kimie Nomura, Kousuke Marutsuka, Maki Nunomura, Noriyasu Fukushima, Takahiro Yagyuu, Hirokazu Nakamine, Futoshi Akiyama, Kazuei Hoshi, Kosei Matsue, Kiyohiko Hatake, Kazuo Oshimi
Journal: Blood (2010)
IMMEDIATE CLOSURE OF TRACHEOTOMY WOUNDS.
Authors: THOMAS C. HOOVER
Journal: JAMA (1905)

The cases reported by Miles F. Porter, M.D., Fort Wayne, Ind., prompt me to report the following: Baby girl, aged 2½ years, referred to me by Dr. Quin, West Jefferson, Ohio, Feb. 18, 1898. The evening before the child had been playing with some corn and a grain lodged in the trachea. When she arrived at my office, having been conveyed in an open buggy eighteen miles, she was breathing easily, but she had a paroxysm of dyspnea while I was examining her. Low tracheotomy was immediately performed and the grain of corn presenting at the tracheal opening was removed without difficulty. I closed the wound throughout with fine catgut, beginning with the trachea. The recovery was prompt and without unfavorable incident. No drain was used. If surgical cleanliness is used there certainly can not be any good reason for using the open method in non-infectious cases of tracheotomy.
Surgical backup needed for non-urgent angioplasties
Authors: D. Spurgeon
Journal: BMJ (2000)

Patients undergoing non-emergency angioplasty in medical centres where surgical backup was not available were twice as likely to die, a study presented last week at the American Heart Association's scientific sessions in New Orleans showed. Patients were also 20% more likely to require bypass surgery elsewhere, the study found.

Percutaneous transluminal coronary angioplasty was introduced in the early 1980s, when it was performed only in hospitals that had onsite, backup surgical teams in case something went wrong. The procedure is now often carried out in units where no such team is available. This has led to controversy over whether the lack of a backup team increases the risk of life threatening complications.

This study should serve as a cautionary flag, said Dr David Wennberg, director of the centre for outcomes research and evaluation at Maine Medical Centre, Portland, Maine, who is also the study's lead investigator. He continued: While single-institution reports have suggested that performing angioplasty without surgical backup is a safe procedure, our data suggest that does not hold true when you look at medical centres and hospitals across the United States.

The importance of a backup team depends on the reason the angioplasty is being done. His study compared more than 2500 angioplasties performed in 1996 and 1997 in 198 institutions across the country without surgical backup with about 365 000 performed in units where there was such a backup.

Patients in the study were in the Medicare programme, which provides health insurance coverage to people aged over 65.

The researchers found that when an emergency angioplasty was performed either at the time of a heart attack or when drugs failed to dissolve a blockage, the lack of a backup made no difference to the outcome of the operations. But when patients were undergoing non-emergency angioplasty, they were much more likely to die or to need another operation elsewhere if no backup team was available. The researchers plan to undertake further studies aimed at understanding why this is so.
REAGINIC ACTIVITY ASSOCIATED WITH I<scp>G</scp>G IMMUNOGLOBULIN
Authors: Robert T. Reid, Percy Minden, Richard S. Farr
Journal: The Journal of Experimental Medicine (1966)

Five human sera with reaginic activity to a number of allergens were fractionated using anion exchange chromatography. In each serum, fractions which contained detectable IgG and no detectable IgA had capacity to fix to skin and subsequently elicit a P-K reaction. Four of these sera had reaginic activity about equally distributed between fractions containing only IgG and fractions containing mixtures of IgG and IgA. A fifth serum contained reaginic activity to crystalline bovine serum albumin (BSA) and most of the activity was associated with the fraction which contained only IgG. This serum was extensively studied using a variety of techniques and it was confirmed that most of the reagin to BSA in this serum was in those fractions containing only IgG. Since reaginic activity can no longer be considered a unique property of IgA the implications of finding antibody with reaginic qualities in immunoglobulins other than IgA are discussed.
Monnica Charlotte Stewart
Authors: Stewart Munday
Journal: BMJ (2005)

Former principal medical officer (adult health) Basingstoke and North Hants (b 1924; q Durham 1950; DObst RCOG), died from cardiac failure on 14 October 2004 a few hours before her brother, Dr Alexander Bryce Stewart (obituary above).​above).




Figure 1




After working in obstetrics in Newcastle upon Tyne, Farnborough, and Newport, Isle of Wight, she changed direction to geriatrics when appointed assistant physician at Edgware General Hospital. She worked for Newham within community medicine and was later appointed principal medical officer for Basingstoke and North Hants. She published My Brother's Keeper in 1968, which anticipated and highlighted future problems for geriatric medicine and home care support. She retired in 1989.
Electrolyzed acid water can cause colitis?
Authors: J. Souza, T. Ribeiro, L. Borges, J. da Silva
Journal: Endoscopy (2008)

We read with great interest the article by Cammarota et al. [1] and the letter of Coriat et al. [2] on the endoscopic finding of chemical colitis (pseudolipomatosis). Cammarota et al. attributed these mucosal changes to the use of hydrogen peroxide flushes following high-level disinfection with automatic machines using peracetic acid, mainly in examinations performed with Fujinon colonoscopies. Coriat et al. thought the cause was inadequate rinsing of endoscopic channels and surfaces with water after immersion in peracetic acid, presumably causing direct irritation of the mucosa.
General Anaesthesia: Basic Principles; Clinical Practice
Authors: John R. Gordon
Journal: JAMA (1966)

This two-volume work follows by some six years the popular first edition which was itself a successor to Evans' Modern Practice of Anaesthesia of 1949. It is offered by 48 authors (all but one of whom work in Britain) as a tribute to the late Prof Ronald Woolmer whose chapter, Some Methods of Measurement in Anaesthesia, appears in both editions.  The first volume deals with basic principles in anaesthesiology and is, in general, the more noteworthy. The sections on neurological principles in anesthesia, the pharmacology of inhalation anesthetics, neuromuscular block, and the pharmacology of relaxant drugs are especially good and include extensive, current bibliographies.  The second volume encompasses a broad group of topics in the clinical practice of general anesthesia. One gains the impression that most anesthesias in Britain consist of a thiopental induction followed by maintenance with nitrous oxide and a long-acting muscle relaxant whose action is terminated by
Extensive bone marrow necrosis in patients with cancer and tumor necrosis factor activity in plasma
Authors: Charles Knupp, Phillip H. Pekala, Peter Cornelius
Journal: American Journal of Hematology (1988)

Abstract Tumor necrosis factor (TNF), a macrophage secretory protein produced by peripheral blood monocytes from patients with cancer, has been shown to possess cytotoxicity toward tumor cells in vitro. TNF in the blood of individuals with cancer is usually not detectable except with extremely sensitive radioimmunoassay or enzyme‐linked immunosorbent assay (ELISA) methods. We have encountered two patients with the rate syndrome of extensive bone marrow necrosis in association with cancer. The first patient presented with marrow failure secondary to necrosis and was found to have adenocarcinoma in thoracic lymph nodes, lung, and marrow lymphatics at autopsy. Plasma tested at two dilutions (1:200 and 1:2,000) contained TNF at a concentration of 8.3 ng/ml, or 80 U/ml by a cytotoxicity assay using LM cells. The presence of TNF was confirmed with immunoblotting. The second patient had a poorly differentiated lymphoid tumor involving bone marrow, pancytopenia, and marrow necrosis. The plasma cytotoxicity assay indicated the presence of 0.7 ng/ml or 7 U/ml TNF. TNF was not detectable in plasma from six other patients with untreated cancer involving bone or bone marrow using either of our methods. The levels of TNF in the two patients with marrow necrosis were greater than those previously measured by others in patients with cancer but were comparable to those noted in patients with lethal sepsis. Since large doses of TNF have been shown to cause organ necrosis in animals, the data presented here are consistent with TNF involvement in mediating the observed marrow necrosis in our patients.
Premixed Insulin Preparations in Pen Syringes Maintain Glycemie Control and Are Preferred by Patients
Authors: Jennifer M Dunbar, Patricia M Madden, Deirdre T Gleeson, Tarek M Fiad, T Joseph McKenna
Journal: Diabetes Care (1994)

OBJECTIVE To examine the impact on glycemie control of substituting a range of premixed insulins for the standard treatment with patient-mixed insulin combinations. In addition, a pen-type syringe was substituted for the conventional insulin syringe, and the patients' preference wasascertained at the end of the study. RESEARCH DESIGN AND METHODS Before the study, all patients had maintained a constant insulin dosage for 2 months. For the first month of the study, all patients were encouraged to make any adjustment in insulin dosage required to optimize control. Twenty-seven patients participated in the study. At the end of the first month, patients were randomized either to change to premixed insulins or to continue with self-mixed insulins for 2 months. At the end of the 2-month period, participants changed to the alternative regime for a further 2 months. Glycemie control was measured by assessment of glycosylated hemoglobin levels at the start of the study and aftereach 2-month period of the study. In addition, during the 1-month run-in period and during both 2-month study periods, a seven-point blood glucose profile was obtained extending from before breakfast to just before retiring for sleep. RESULTS Glycosylated hemoglobin levels were unchanged throughout the duration of the study. Similarly, there were no systematic changes inindividual seven-point blood glucose profiles. The frequency of hypoglycemie reactions was similar on patient-mixed and premixed insulin programs. However, 83% of patients expressed a preference for premixed insulins. A similar percentage regarded pen-type insulin syringes to be preferable to the conventional syringe. CONCLUSIONS Glycemie control was similar on patient-mixed and premixed insulins, and patients had a marked preference for premixed insulins delivered in a pen-type syringe over conventional insulin therapy. Premixed insulin delivered by a pen-type syringe promises to ease the burden of daily injections for many diabetic patients.
AIDS and Compassion
Authors: Gerald Friedland
Journal: JAMA (1988)

Friedland, a physician, explores what he believes are the three reasons why there has been a lack of compassion toward AIDS patients. He identifies fear of transmission, views of the social worth of individuals (particularly homosexuals and drug users), and the nature of plagues in our minds and history as the underlying causes for the lack of compassion in our treatment of persons with AIDS. Friedland responds to this problem by suggesting ways in which a compassionate response to the AIDS epidemic might be developed at the societal, professional, and personal levels.
On some Points of Interest to the General Practitioner
Authors: J. Ramsay
Journal: BMJ (1888)

scend to form a precipitate without showing any tendency to again permeate the fluid.Iood.-In his remarks on the subject of food Dr. Woodman ex- pressed his opinion that man is an omnivorous animal, and should not be either a vegetarian or an excessive meat-eater.Moderation in eating and drinng should be observed.Schoots.-In Exeter the co-operation of school teachers has been secured in dealing with infectious diseases.Affected scholars are watched for and excluded from attendance, as well as children from infected houses.
The Precision of the Conjunctival Provocation Test
Authors: Christian Möller, Bengt Björksten, Göran Nilsson, Sten Dreborg
Journal: Allergy (1984)

Repeated conjunctiva] provocation tests ICPT) were done in 20 children with rhino‐conjunctivitis due to birch pollen allergy. Compared with the first open challenge, three successive blinded CPTs were reproducible within an allergen strength difference of one 10‐potency in 92 of the tests. Based on the data, a power function was constructed, making it possible to determine the number of patients needed to discriminate CRT sensitivity of a given magnitude between two populations. During the study period specific serum‐IgE increased in only three of 19 patients, indicating that stimulation of IgE antibody production is not a common consequence of repeated tests. We conclude that CPT is useful in clinical research. When indicated in clinical routine. CPT is a sale and easy test with good precision.
Use and Overuse of Angiography and Revascularization for Acute Coronary Syndromes
Authors: R. A. Lange, L. D. Hillis
Journal: New England Journal of Medicine (1998)

Over the past two decades, clinical and pathological studies have examined the pathophysiology of the acute coronary syndromes, unstable angina, and non–Q-wave and Q-wave myocardial infarction. In these conditions, rupture of atherosclerotic plaques leads to varying amounts of platelet adhesion and aggregation, vasoconstriction, and the formation of partially or totally occlusive thrombus. Although the inhibition of platelet aggregation and thrombus formation and the restoration of antegrade flow in occluded coronary arteries improve survival and reduce the incidence of recurrent ischemia and infarction, residual coronary-artery stenosis may cause ischemia, infarction, or even death. As a result, there has been considerable interest . . .
Education and Use of Nurses: It's about Time!
Authors: LeRoy A. Pesch
Journal: New England Journal of Medicine (1972)

AT a time when the total expenditures for health care in this country have surpassed 7 per cent of the gross national product ($75 billion in 1971) and one in 20 persons employed in this country works in the health-care industry, it is about time someone began to take a hard look at the irrationality inherent in present manpower policies, which are predicated on an attractive but very erroneous assumption that this country of abundance somehow has unlimited resources to expend on a health-care system. The plethoric tide of new professionals appearing within the health-care-manpower marketplace is an example of . . .
New FDA Regulation to Improve Safety Reporting in Clinical Trials
Authors: Rachel Behrman Sherman, Janet Woodcock, Janet Norden, Cheryl Grandinetti, Robert J. Temple
Journal: New England Journal of Medicine (2011)

duce the likelihood of litigious arguments concerning who knew what and when. 5Individual manufacturers should not be in the position of determining what information is considered material for public dissemination.Physicians are also well aware that our noninfallible but important recommendations are based on our best assessments of incomplete data, with levels of evidence ranging from firm to anecdotal.With the finality afforded by the Supreme Court decision in Matrixx, investors can be assured of increased access to statistically nonsignificant information regarding reports of adverse drug experiences.Although the medical establishment lacks legal authority, it could use its standards-setting powers to improve access to the same level of information.The resulting flood of data, though likely to represent biologic noise rather than evidence sufficient to establish even "probable cause," would contribute to the total mix of available information and might, under some circumstances, influence reasonable prescribers and patients to alter their treatment plans: a sommelier, for example, might consider any report of anosmia to be material.
Abstract 2045: BubR1 is modified by sumoylation during mitotic progression
Authors: Feikun Yang, Liyan Hu, Yixin Yao, Jianxiu Yu, Alexey Khodjakov, Michele Pagano, Wei Dai
Journal: Cancer Research (2012)

Abstract BubR1 functions as a crucial component that monitors proper chromosome congression and mitotic timing during cell division. We investigated molecular regulation of BubR1 and found that BubR1 was modified by an unknown post-translation mechanism during the cell cycle, resulting in a significant mobility shift on denaturing gels. We termed it BubR1-M as the nature of modification was not characterized. Extended (&amp;gt;24 h) treatment of HeLa cells with a microtubule disrupting agent including nocodazole and taxol or release of mitotic shake-off cells into fresh medium induced BubR1-M. BubR1-M was derived from neither phosphorylation nor acetylation. Ectopic expression coupled with pulling down analyses showed that BubR1-M was derived from SUMO modification. Mutation analysis revealed that lysine 250 was a crucial site for sumoylation. Significantly, compared with the wild-type control, ectopic expression of a sumoylation-resistant mutant of BubR1 induced chromosomal missegregation and mitotic delay. Combined, our study identifies a new type of post-translational modification that is essential for BubR1 function during mitosis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2045. doi:1538-7445.AM2012-2045
Species variation in arterial-myocardial sensitivity to verapamil
Authors: P. QUINN, M. G BRISCOE, A. NUTTALL, H. J SMITH
Journal: Cardiovascular Research (1981)

The changes in tension with increasing calcium concentration were examined in papillary muscles isolated from cats, rabbits, and rats, and in isolated rat atria. Similar curves were determined for cat femoral artery and lower descending aorta from rabbits and rats. In all tissues, the concentration of verapamil (KB) was determined which achieved a calcium dose ratio of 2. Rat myocardium was the most (KB = 3.38 +/- 0.18 X 10(-6) mol . litre-1) and rabbit the lest (KB = 1.18 +/- 0.01 X 10(-5) mol . litre-1) sensitive to verapamil. Cat tissue was intermediate; rat atria and ventricle were similar. By contrast, arterial sensitivity was always greater with arterial-myocardial sensitivity ratios varying from 175 +/- 7 in the cat to 1073 +/- 97 in the rabbit. This technique is a formal evaluation of the arterial-myocardial sensitivity of calcium entry blockers and may permit prediction of the myocardial and vasodilator properties of novel compounds.
Adjustable gastric banding improved glycemic control in obese patients with type 2 diabetes
Authors: Raj Padwal
Journal: Annals of Internal Medicine (2008)

ACP Journal Club15 July 2008Adjustable gastric banding improved glycemic control in obese patients with type 2 diabetesRaj Padwal, MDRaj Padwal, MDUniversity of Alberta, Edmonton, Alberta, Canada (R.P.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-2-200807150-02003 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationDixon JB, O’Brien PE, Playfair J, et al. Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial. JAMA. 2008;299:316-23. https://pubmed.ncbi.nlm.nih.gov/18212316Clinical Impact RatingsEndocrinology: References1 Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292:1724-37. [PMID: 15479938] Google Scholar2 Sjöström L, Narbro K, Sjöström CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357:741-52. [PMID: 17715408] Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Alberta, Edmonton, Alberta, Canada (R.P.)This article was published at Annals.org on 1 July 2008. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 July 2008Volume 149, Issue 2Page: JC1-3KeywordsBariatric surgeryComputed axial tomographyHbA1cInsulinMorbid obesityNutritionObesityOverweightSurgeryType 2 diabetes ePublished: 15 July 2008 Issue Published: 15 July 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Aldosterone Blockade and Heart Failure
Authors: Mariell Jessup
Journal: New England Journal of Medicine (2003)

In the fall of 1999, a multicenter, randomized trial examining the effect of spironolactone on morbidity and mortality among patients with severe heart failure was published in the Journal.1 The Randomized Aldactone Evaluation Study (RALES) proved that antagonism of aldosterone had an important role in the management of heart failure, even in patients taking angiotensin-converting–enzyme (ACE) inhibitors. In addition to reducing mortality by 30 percent, small doses of spironolactone resulted in an improvement in ventricular function and enhanced exercise tolerance.2 The rates of death from progressive heart failure and sudden death from cardiac causes were both diminished by an . . .
THE METABOLIC CLEARANCE RATE OF ALDOSTERONE IN PREGNANT AND NONPREGNANT SUBJECTS ESTIMATED BY BOTH SINGLE-INJECTION AND CONSTANT-INFUSION METHODS*
Authors: J. F. Tait, B. Little, S. A. S. Tait, C. Flood
Journal: Journal of Clinical Investigation (1962)

Jones and colleagues (1) found that the pattern of urinary metabolites of aldosterone was changed in pregnant compared with nonpregnant subjects.The ratio, however, of the secretion rate to the urinary free aldosterone, which was taken to indicate the over-all metabolic rate, was not appreciably altered.Daughaday (2) and Meyer (3) and their as- sociates found that the binding of aldosterone to plasma proteins other than albumin was the same for nonpregnant and pregnant subjects and for subjects treated with small amounts of estro- gens.The unaltered binding, unlike that of cortisol, might suggest that the over-all metab- olism of aldosterone is unchanged in pregnancy.Tait and co-workers (4) described methods for the calculation of volumes of distribution and rate constants by measurement of the plasma radioactivity, as aldosterone, as a function of time after a single injection of the tritiated hor- mone.In addition, the ratio of the secretion rate to the plasma steroid concentration, which is a measure of the over-all metabolic process, could be calculated both after a single injection and after constant infusion of radioactive steroid.This ratio was previously termed a "turnover rate" (4), but as it has the dimensions of volume divided by time, it will henceforward be referred to as the "metabolic clearance rate" (MCR) of the steroid.In the present paper, the single- injection and constant-infusion methods for estimating MCR are compared for both preg- nant and nonpregnant subjects.The MCR
Chalk5 encodes a vacuolar H+-translocating pyrophosphatase influencing grain chalkiness in rice
Authors: Yibo Li, Chuchuan Fan, Yongzhong Xing, Peng Yun, Lijun Luo, Bao Yan, Bo Peng, Weibo Xie, Gongwei Wang, Xianghua Li, Jinghua Xiao, Caiguo Xu, Yuqing He
Journal: Nature Genetics (2014)