tbuckley/cabot-search huggingface dataset:
Factor V anticoagulants: clinical, biochemical, and immunological observations
Authors: Donald I. Feinstein, Samuel I. Rapaport, William G. McGehee, Mary Jane Patch
Journal: Journal of Clinical Investigation (1970)

A patient who had received multiple transfusions for complications of acute hemorrhagic pancreatitis developed a potent factor V anticoagulant with bleeding due to defective hemostasis. Despite its potency, the anticoagulant disappeared within 15 days of its first manifestation. A second patient with adenocarcinoma of the colon developed an anticoagulant to factor V postoperatively after a single blood transfusion. The anticoagulants appeared to react stoichiometrically with factor V in normal plasma in vitro. They had the physicochemical properties of immunoglobulins, and their activity was neutralized by antihuman immunoglobulin antiserum. One anticoagulant appeared to be slightly more active against homologous than against autologous factor V, but it also inhibited heterologous factor V. Both anticoagulants progressively inactivated intrinsic prothrombin activator formed from normal reagents in the incubation mixture of the thromboplastin generation test, thus confirming that factor V is required for the effective action of the intrinsic prothrombin activator. Since the anticoagulants were immunoglobulins whose activity was consumed in their reaction with factor V, consumption of anticoagulant activity was used to detect factor V antigenic material in test materials. Human serum without factor V clotting activity was found to consume anticoagulant activity, i.e., to contain inactive factor V antigenic material. Plasma from two patients with hereditary factor V deficiency (parahemophilia) failed to consume significant anticoagulant activity. Thus, the lack of factor V activity in these patients represents a deficiency of factor V molecules rather than the synthesis of a defective molecule with impaired clotting activity.
Genetic linkage of cone–rod retinal dystrophy to chromosome 19q and evidence for segregation distortion
Authors: Kevin Evans, Alan Fryer, Christopher Inglehearn, Josephine Duvall-Young, Joanne L. Whittaker, Cheryl Y. Gregory, Rachel Butler, Neil Ebenezer, David M. Hunt, Shomi Bhattacharya
Journal: Nature Genetics (1994)
Growth Factors and Adipocytokines in Prepubertal Children Born Small for Gestational Age
Authors: Anna S. Challa, Eleni N. Evagelidou, Vasilios I. Cholevas, Dimitrios N. Kiortsis, Vasileios I. Giapros, Aikaterini A. Drougia, Styliani K. Andronikou
Journal: Diabetes Care (2009)

The aim of this study was to test whether being born small for gestational age (SGA) has an impact on adiponectin and leptin levels and the IGF system in relation to insulin sensitivity, taking into consideration the severity of growth restriction.
(33) Anhidrotic ectodermal dysplasia in three unrelated females
Authors: R. Cerio, R.S. Wells
Journal: British Journal of Dermatology (1985)

Journal Article (33) Anhidrotic ectodermal dysplasia in three unrelated females Get access R. Cerio, R. Cerio Department of Dermatology, Guy's Hospital, London SB1 Search for other works by this author on: Oxford Academic Google Scholar R.S. Wells R.S. Wells Department of Dermatology, Guy's Hospital, London SB1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Pages 78–79, https://doi.org/10.1111/j.1365-2133.1985.tb13048.x Published: 01 July 1985
Madness, Morality and Medicine: A Study of the York Retreat, 1796-1914
Authors: Steven S. Sharfstein
Journal: JAMA (1986)

This book is a superb historical study of one of the most significant experiments in the treatment of mental illness, the York Retreat. It is part of the Cambridge History of Medicine series and details the theories and technologies of 19th-century psychiatry from the perspective of a special setting for psychiatric care. It is not only important on its own merits but also provides a basis for contemporary discussion on the nature of mental illness and effective psychiatric treatment. The York experiment in "kind and firm moral reeducation" of the insane was a combination of the religious idealism of the founding Quakers and the conceptions of 19th-century medical psychiatry. The Quaker community was galvanized by a young Quaker woman's death in the state-supported York asylum in 1790. Imbued with the religious perspective that "a life is one's testimony," the York Retreat emphasized humane approaches to care and treatment of mentally
Effect of exercise training in patients with coronary artery disease on circulating endothelial progenitor cells
Authors: Karsten Lenk, Volker Adams, Marcus Sandri, Atila Tarnok, Dominik Lenz, Andrej Schmidt, Dirk Scheinert, Dirk Scheinert, Gerhard Schuler, Rainer Hambrecht
Journal: Journal of the American College of Cardiology (2003)
SOME PROFESSIONAL REMINISCENCES.
Authors: GEORGE F. SHRADY
Journal: JAMA (1907)

Every one who travels even an ordinary road has experiences of his own. If he can apply them to the good of any of his fellow-creatures he is serving in a very general way the common interests of humanity. There is always something, if he only turns his head in the right direction, that he may see in a new light. At certain times we react more sharply to the controlling circumstances of environment than ordinarily. It is the question of the man, the gun, the aim and the game being in proper line. Too often, alas! we not only miss the mark, but get kicked by the recoil. Thus the physician, by virtue of his judicial office, soon learns not only to think before he speaks, but oftentimes not to say what he thinks. His face must never be the mirror of his soul. To manifest surprise at any
Erosion of Phalanges by Subungual Warts
Authors: Lewis Shapiro
Journal: JAMA (1961)

THE FACT that benign masses, by pressing on bone, are capable of causing bony resorption is well known. Glomangioma, the subungual tumors of the tuberous sclerosis complex, and giant-cell tumor of tendon sheath<sup>1</sup>have specifically been reported as eroding terminal phalanges of fingers. However, the erosion of the terminal phalanges of fingers by subungual warts has not been reported in the medical literature to the best of our knowledge, and an authority such as Brailsford<sup>2</sup>is unacquainted with any known case of phalangeal erosion produced by warts. It is, therefore, our desire to report the following case. <h3>Report of a Case</h3> A woman, aged 24 years, was first seen on Oct. 1, 1959, complaining of 2 somewhat tender lesions which had developed gradually during the preceding year. Prior therapy had consisted of one application of "acid" at another hospital 4 months previously. Her past history was irrelevant,
Augmenting Obsessive-Compulsive Disorder Treatment
Authors: Kerry J. Ressler, Barbara O. Rothbaum
Journal: JAMA Psychiatry (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
689 INVALIDATION OF THE VITAMIN D NUCLEAR RECEPTOR PROMOTES BILIARY-TYPE LIVER INJURY
Authors: P. Firrincieli, S. Zuñiga, C. Rey, D. Wendum, E. Lasnier, D. Rainteau, A. Cadoret, M. Boissan, C. Housset, N. Chignard
Journal: Journal of Hepatology (2011)
Rupture of Liver Associated with Parturition
Authors: J. R. C. Burton-Brown, J. A. Shepherd
Journal: BMJ (1949)

BRDICgJRNAL 941given in Chart 2. The protein content of the ascitic fluid varied between 2 and 2.5 g. %.By this time the patient was markedly emaciated and the abdomen was grossly distended by ascitic fluid and a large spleen, which reached right down into the pelvis.His liver, however, was only slightly enlarged.On July 2 an estimation of the plasma protein gave a reading of 5.1 g. %, and a hippuric-acid test showed that the amount of hippuric acid passed in the four-hour period was only 2.7922 g., with the maximum excretion in the second hour.It was therefore decided to give 1 g. of choline chloride and 1 g. of cystine twice daily.This was done on the assumption that choline and cystine can help to prevent hepatic cirrhosis due to a very low protein intake.The hippuric-acid tests were repeated, with the following results
Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction
Authors: Steven M. Devine, Ravi Vij, Michael Rettig, Laura Todt, Kiley McGlauchlen, Nicholas Fisher, Hollie Devine, Daniel C. Link, Gary Calandra, Gary Bridger, Peter Westervelt, John F. DiPersio
Journal: Blood (2008)
Investigations on the Relations of Rheumatoid Arthritis and Rheumatic Fever to Allergy
Authors: E. G. L. Bywaters
Journal: Annals of the Rheumatic Diseases (1950)

This thesis from Professor Holsti's clinic in Helsinki University performs a very useful function.It examines the interrelations between rheumatoid arthritis, rheumatic fever, and allergy, using the patients attending over 14 years at the Medical Clinic in Helsinki.
Late “Rim Sign”—A Variant of an Old Sign
Authors: MICHAEL E. SPIETH, JOHN S. SEDER, JOHN C. STAUFFER, ROBERT E. JAMES, FAROOQ ALI, JOYCE A. ODOM, ROBYN L. KIMURA
Journal: Clinical Nuclear Medicine (1994)

Classically, the “rim sign” has been described throughout the hepatobillary scan. The authors present a case of a late rim sign visualized at 25 minutes postinjection that proved to be acute upon chronic acalculous cholecystis without gangrene.
Pathological Vascular Invasion and Tumor Differentiation Predict Cancer Recurrence in Stage ia Non–Small-Cell Lung Cancer After Complete Surgical Resection
Authors: Yoshihisa Shimada, Hisashi Saji, Koichi Yoshida, Masatoshi Kakihana, Hidetoshi Honda, Masaharu Nomura, Jitsuo Usuda, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
Journal: Journal of Thoracic Oncology (2012)
Lack of gene–diuretic interactions on the risk of incident gout: the Nurses’ Health Study and Health Professionals Follow-up Study
Authors: Ying Bao, Gary Curhan, Tony Merriman, Robert Plenge, Peter Kraft, Hyon K Choi
Journal: Annals of the Rheumatic Diseases (2015)

Background Diuretic-induced gout might occur only among those with a genetic predisposition to hyperuricaemia, as suggested by a recent study with 108 self-reported gout cases. Methods We examined the role of urate genes on the risk of diuretic-induced incident gout in 6850 women from the Nurses’ Health Study (NHS) and in 4223 men from the Health Professionals Follow-up Study (HPFS). Two published genetic risk scores (GRSs) were calculated using urate-associated single-nucleotide polymorphisms for 8 (GRS8) and 29 genes (GRS29). Results Our analyses included 727 and 354 confirmed incident gout cases in HPFS and NHS, respectively. The multivariate relative risk (RR) for diuretic use was 2.20 and 1.69 among those with GRS8 &lt; and ≥ the median (p for interaction=0.27). The corresponding RRs using GRS29 were 2.19 and 1.88 (p for interaction=0.40). The lack of interaction persisted in NHS (all p values &gt;0.20) and in our analyses limited to those with hypertension in both cohorts. SLC22A11 (OAT4) showed a significant interaction only among women but in the opposite direction to the recent study. Conclusions In these large prospective studies, individuals with a genetic predisposition for hyperuricaemia are not at a higher risk of developing diuretic-induced gout than those without.
Controversies in Neuroscience V: Persistent pain: Neuronal mechanisms and clinical implications: Introduction
Authors: Bill Roberts, Paul Cordo, Stevan Harnad
Journal: Behavioral and Brain Sciences (1997)

Pain is not a single entity but is instead a collection of sensory experiences commonly associated with tissue damage. There is growing recognition that not all pains are equivalent, that pains and pathologies are not related in a simple manner, and that acute pains differ in many respects from persistent pains. Great strides have been made in improving our understanding of the neuronal mechanisms responsible for acute pain, but the studies leading to these advances have also led to the realization that a bewildering array of processes are interposed between tissue damage and sensations of pain, especially in persistent pains. Persistent pains often seem unrelated or disproportionate to identifiable pathology, and they are modulated by a multitude of factors. This complexity in such a vital function serves as a challenge both to scientists seeking fundamental understanding and to clinicians faced with the immediate need to treat patients with painful disorders.
Subcutaneous morphoea: a clinical study of sixteen cases
Authors: JOHN R. PERSON, W.P.DANIEL SU
Journal: British Journal of Dermatology (1979)

Sixteen patients had biopsy-proved inflammatory sclerosis of the panniculus or fascia, which usually was seen in a generalized distribution. Although the sclerosis involved the digits of five patients, it was the result of centrifugal spread of the sclerosis and was not accompanied by ulcers, calcinosis, distal phalangeal resorption or telangiectasia. Four patients may have had digital vasopasm in the extremities involved in the sclerotic process. Five patients also had cutaneous lesions of dermal morphoea or lichen sclerosus et atrophicus. Four patients had a reduced carbon monoxide diffusing capacity, and one of these had roentgenographic evidence of pulmonary fibrosis. In three patients, oesophageal motility or barium swallow studies showed evidence of sclerodermatous changes. The sclerotic process was a contributory cause of the death of one patient. Five patients had peripheral eosinophilia. Six patients seemed to have responded to anti-inflammatory agents. We believe that subcutaneous morphoea is generally more inflammatory than generalized morphoea of the dermal type and may be more likely to progress to mild systemic sclerosis. We suggest that response of subcutaneous morphoea to anti-inflammatory agents is simply a reflection of the degree of inflammation present.
Brain Damage From Chronic Alcoholism
Authors: Frederick Lemere
Journal: JAMA (1976)

<h3>To the Editor.—</h3> We were most interested in the article by Fox et al (236:365, 1976), in which cerebral ventricular enlargement was found in eight of 12 chronic alcoholics examined by computerized tomography (CT). In none of these eight patients was there an abnormal mental status on discharge. This further confirms the findings of autopsy, pneumoencephalography, and clinical observations that chronic alcoholism often causes gradual, irreversible injury to the brain. Evidence of such damage, however, is often difficult to demonstrate to the patient. Objective. proof of brain, liver, or other organic pathological findings caused by excessive alcohol consumption, when available, can often motivate the patient to stop drinking for health reasons. The usual psychological and mental status tests for brain damage are too inconclusive and appear too late in the disease of alcoholism to be of much help in warning the patient of the mental hazards involved. We have found
Notable intrafamilial phenotypic variability in a kindred with familial adenomatous polyposis and an APC mutation in exon 9
Authors: P Rozen, Z Samuel, R Shomrat, C Legum
Journal: Gut (1999)

<h3>BACKGROUND</h3> The phenotypic spectrum of familial adenomatous polyposis (FAP) varies from the classic appearance of hundreds of adenomatous colonic polyps in the young adult and early onset colorectal cancer, to the occurrence of sparse adenomas in the older adult, “attenuated” FAP, due to mutations at the 5′ or 3′ ends of the <i>APC</i> gene. <h3>AIMS</h3> To investigate marked intrafamilial phenotypic variation occurring in a family with an<i>APC</i> gene mutation in exon 9. <h3>PATIENTS</h3> An extended kindred of 22 people of whom 16 had colorectal neoplasia and/or were<i>APC</i> mutation carriers. <h3>RESULTS</h3> Phenotypic manifestation varied from classic FAP to a complete lack of clinical or endoscopic, or bioptic disease in five people in three different generations. This occurred in four of them over two generations, in spite of having a confirmed 11 bp insertion causing a frame shift and stop codon (363) in exon 9 of the <i>APC</i> gene. <h3>CONCLUSIONS</h3> At present, it is assumed that in this family there is alternative splicing of the<i>APC</i> gene, and/or unidentified modifying genetic factors. The family illustrates the importance of genetic testing in evaluating carrier status and not just clinical examination. This clinical observation also high- lights the dilemma in recognising the possible contribution of low penetrance germline<i>APC</i> mutations to what has been considered “sporadic” colorectal neoplasia.
Increased Fas Expression Reduces the Metastatic Potential of Human Osteosarcoma Cells
Authors: Elizabeth A. Lafleur, Nadezhda V. Koshkina, John Stewart, Shu-Fang Jia, Laura L. Worth, Xiaoping Duan, Eugenie S. Kleinerman
Journal: Clinical Cancer Research (2004)

Abstract Purpose: The process of metastasis requires the single tumor cell that seeds the metastatic clone to complete a complex series of steps. Identifying factors responsible for these steps is essential in developing and improving targeted therapy for metastasis. Resistance to receptor-mediated cell death, such as the Fas/Fas ligand pathway, is one mechanism commonly exploited by metastatic cell populations. Experimental Design and Results: LM7, a subline of the SAOS human osteosarcoma cell line with low Fas expression, was selected for its high metastatic potential in an experimental nude mouse model. When transfected with the full-length Fas gene (LM7-Fas), these cells expressed higher levels of Fas than the parental LM7 cells or LM7-neo control-transfected cells. These cells were also more sensitive to Fas-induced cell death than controls. When injected intravenously into nude mice, the LM7-Fas cell line produced a significantly lower incidence of tumor nodules than control cell lines. Lung weight and tumor nodule size were also decreased in those mice injected with LM7-Fas. Levels of Fas were quantified in osteosarcoma lung nodules from 17 patients. Eight samples were Fas negative, whereas the remaining 9 were only weakly positive compared with normal human liver (positive control). Conclusions: Our results demonstrate that altering Fas expression can impact the metastatic potential of osteosarcoma cells. We conclude that the increase of Fas on the surface of the LM7 osteosarcoma cells increased their sensitivity to Fas-induced cell death in the microenvironment of the lung, where Fas ligand is constitutively expressed. Thus, loss of Fas expression is one mechanism by which osteosarcoma cells may evade host resistance mechanisms in the lung, increasing metastatic potential. Fas may therefore be a new therapeutic target for osteosarcoma.
320 THE HEPATITIS C VIRUS NON-STRUCTURAL 3/4A PROTEASE MEDIATES AN INTRAHEPATIC T HELPER(Th)-1 TO Th2 SHIFT BY CLEAVING THE T CELL PROTEIN TYROSINE PHOSPHATASE
Authors: E.D. Brenndörfer, A. Brass, J. Karthe, G. Ahlen, J.G. Bode, M. Sällberg
Journal: Journal of Hepatology (2013)
BCL2 and JUNB abnormalities in primary cutaneous lymphomas
Authors: X. Mao, G. Orchard, D.M. Lillington, F.J. Child, E.C. Vonderheid, P.C. Nowell, M. Bagot, A. Bensussan, R. Russell-Jones, B.D. Young, S.J. Whittaker
Journal: British Journal of Dermatology (2004)

Background BCL2 is upregulated in nodal and extranodal B-cell non-Hodgkin's lymphomas, with a consequent antiapoptotic effect. However, loss of BCL2 has also been noted in some malignancies, suggesting a different molecular pathogenesis. Objectives To investigate genomic and protein expression status of BCL2 and to compare the results with that of JUNB in primary cutaneous lymphomas (PCLs). Methods We analysed gene copy number of BCL2 and JUNB in 88 DNA samples from 80 patients with PCL consisting of Sézary syndrome/mycosis fungoides (SS/MF), primary cutaneous B-cell lymphoma (PCBCL) and primary cutaneous CD30+ anaplastic large cell lymphoma (C-ALCL) by the use of real-time polymerase chain reaction (PCR) and immunohistochemistry (IHC). Real-time PCR and IHC findings were subsequently compared with the results of additional fluorescent in situ hybridization (FISH) analysis of 23 cases of SS and Affymetrix cDNA expression microarray study of two primary cutaneous T-cell lymphoma (CTCL) cell lines. Results Real-time PCR analysis showed loss of BCL2 gene copy number in 22 of 80 PCL cases (28%), including 17 of 42 SS/MF, three of 13 C-ALCL and two of 33 PCBCL samples, and gain of BCL2 in four PCBCL samples. Gain of JUNB was identified in 18 of 71 PCL cases (25%), including nine of 35 SS/MF, seven of 13 C-ALCL and two of 31 PCBCL samples. IHC analysis revealed absent nuclear expression of BCL2 protein in 47 of 73 PCL cases, comprising 28 of 36 SS/MF, eight of eight C-ALCL and 11 of 29 PCBCL cases. In contrast, BCL2 protein expression was detected in 26 of 73 PCL cases, consisting of 18 of 29 PCBCL and eight of 36 SS/MF cases. JUNB protein expression was present in tumour cells from 30 of 33 of SS/MF and eight of eight C-ALCL, and was absent in tumour cells from 18 of 27 PCBCL cases. A comparison between BCL2 and JUNB revealed loss of BCL2 and gain of JUNB in five of 35 SS/MF samples, and expression of JUNB protein and absent BCL2 expression in 25 SS/MF and eight of eight C-ALCL cases. In contrast, expression of BCL2 and absent JUNB expression were detected in 67% of PCBCL cases. Additional FISH analysis revealed deletion of BCL2 in 19 of 23 SS cases (83%), including eight cases with BCL2 loss shown by real-time PCR. Furthermore, Affymetrix expression microarray demonstrated decreased expression of proapoptotic and antiapoptotic genes involved in BCL2 signalling pathways such as BOK, BIM, HRK, RASA1 and STAT2 in two CTCL cell lines with BCL2 loss and absent BCL2 expression. Increased expression of JUNB was also identified in the MF cell line. Conclusions These findings provide a comprehensive assessment of BCL2 and JUNB status in PCL, and suggest that there is a selection pressure in a subset of CTCL cases for tumour cells showing BCL2 loss and upregulation of JUNB primarily through chromosomal deletion and amplification, respectively.