tbuckley/cabot-search huggingface dataset:
Abstract 4791: Inhibition of Tumor Formation in Mice following Vaccination with DNA Encoding a Novel Xenogeneic Tumor Associated Auto-Antigen
Authors: Robert K. Bright, Jennifer D. Bright, Heather N. Schultz
Journal: Cancer Research (2010)

Abstract Tumor protein D52 (TPD52) is a novel auto-antigen involved in cellular transformation, proliferation and metastasis. Its over-expression has been demonstrated in several human malignancies including prostate, breast, and ovarian carcinomas. Murine TPD52 (mD52) has been shown to induce anchorage independent growth in vitro and spontaneous metastasis in vivo. Importantly, mD52 mirrors the function and normal tissue expression patterns of the human orthologue of TPD52 (hD52) and shares 86% identity at the amino acid level. Thus, TPD52 represents a self, non-mutated tumor associated auto-antigen that is important for maintaining a tumorigenic phenotype. The Transgenic Adeno-carcinoma of the Mouse Prostate (TRAMP) model was employed to study TPD52 as a vaccine antigen. Naïve mice were immunized with either mD52 or hD52 DNA. Following immunization, mice were challenged with a subcutaneous, tumorigenic dose of mD52 positive, autochthonous TRAMP-C1 tumor cells. Greater than 70% of mice were tumor free more than 10 months post tumor challenge when immunized with hD52 as a xenogenic DNA vaccine. Survivors of the initial tumor challenge rejected a second tumor challenge with TRAMP-C2 tumor cells given in the opposite flank approximately 138 days after the first challenge with TRAMP-C1, and remained tumor free for more than 6 months. The T cell cytokine secretion patterns from tumor challenge survivors indicated that a cellular immune response was involved in tumor rejection. These data suggest that hD52 xenogeneic DNA vaccination induced a memory, cellular immune response that resulted in superior protection from challenge with murine prostate-derived tumors that naturally over-express mD52 protein. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4791.
Prevalence of IgE Specific to Profilin in a Texas and California Population
Authors: Greg A. Plunkett, Domingo Barber, Eliseo M. Villalobos, Joshua S. Jacobs, Jeffrey S. Hallett, Tara Mostofi, Agustin Galan Nieto, Tricia Moore
Journal: Journal of Allergy and Clinical Immunology (2013)
Case 20-1983
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Jeffrey A. Gelfand, John P. Grabbe
Journal: New England Journal of Medicine (1983)

Presentation of CaseA 33-year-old man was admitted to the hospital because of a question of heatstroke.He was well until one week earlier, when he began to have occasional headaches. One day before admission he worked outdoors in a gasoline station while the ambient temperature rose to 32.2°C He felt hot and dry and submerged himself in a swimming pool; he was not improved and began to shiver. That evening he was taken to another hospital, where examination showed that his temperature was 41.1°C, the pulse 110, and the blood pressure 130/80 mm Hg. He was alert; his skin . . .
Forcible Administration of Antipsychotic Medication
Authors: Henry R. Arkin
Journal: JAMA (1984)

With growing numbers of involuntarily committed patients refusing antipsychotic drugs, state and federal courts have been called on to determine and balance the rights of patients and the duties of the state. Arkin, an attorney with the Office of the General Counsel of the American Medical Association, discusses the complex legal controversies involved, focusing particularly on several related cases as they wound their way through the Massachusetts Supreme Judicial Court, federal district and appellate courts, and the U.S. Supreme Court.
The Liver: Morphology, Biochemistry, Physiology. Vol. II
Authors: F. W. HOFFBAUER
Journal: JAMA (1964)

The second volume of this treatise contains 15 chapters and covers a wide range of subjects. An extensive chapter on experimental toxic injury of the liver has been prepared by the editor, C. Rouiller of Geneva. The other chapters were prepared by investigators well equipped to write authoritatively by virtue of their own contributions to the field. Half of the authors come from centers in this country, the others from various laboratories in Europe. The excretory function of the liver, the functions of the Kupffer cells, the role of the liver in the metabolism of vitamins and of steroid hormones receive attention in separate chapters. The section devoted to liver regeneration, prepared by Elizabeth Leduc, is concise and informative. The chapters on blood coagulation in relation to liver disease and that on death of liver tissue are exceptionally good. A major portion of Volume II concerns experimental liver injury, with
SIMPLIFIED OPERATION FOR CHALAZIO[ill]
Authors: Robert Scott Lamb
Journal: JAMA (1910)

Ophthalmic surgeons have from time to time had recurrences after incising and curetting chalazia and I desire to call attention to a simple procedure which prevents the reforming of secretion in a not quite obliterated cyst wall. After anesthetizing the conjunctiva a chalazion forceps grasps the lid surrounding the tumor and the usual incision of the conjunctiva and the sac beneath is made at right angles to the lid margin. The contents are then carefully removed with a curette and the bleeding controlled. A strabismus hook is then heated red over an alcohol flame, or an electric cautery point is used to gently touch the interior of the sac and so destroy the secreting surface. This has the obvious advantage over extirpation of simplifying the operation and the after-treatment and of lessening the trauma. Previously I had used tincture of iodin, and at another period phenol, but nothing has been
Estuary-associated syndrome in North Carolina: an occupational prevalence study.
Authors: M Swinker, D Koltai, J Wilkins, K Hudnell, C Hall, D Darcey, K Robertson, D Schmechel, W Stopford, S Music
Journal: Environmental Health Perspectives (2001)

Atlantic coast estuaries recently have experienced fish kills and fish with lesions attributed to Pfiesteria piscicida and related dinoflagellates. Human health effects have been reported from laboratory exposure and from a 1997 Maryland fish kill. North Carolina has recorded Pfiesteria-related fish kill events over the past decade, but human health effects from environmental exposure have not been systematically investigated or documented here. At the request of the state health agency, comprehensive examinations were conducted in a cross-sectional prevalence study of watermen working where Pfiesteria exposure may occur: waters where diseased or stressed fish were reported from June to September 1997, and where Pfiesteria had been identified in the past. Controls worked on unaffected waterways. The study was conducted 3 months after the last documented Pfiesteria-related fish kill. The goal was to document any persistent health effects from recent or remote contact with fish kills, fish with lesions, or affected waterways, using the 1997 U.S. Centers for Disease Control and Prevention case description for estuary-associated syndrome (EAS). Examinations included comprehensive medical, occupational, and environmental history, general medical, dermatologic, and neurologic examinations, vision testing, and neuropsychologic evaluations. Seventeen of 22 watermen working in affected waters and 11 of 21 in unaffected waters reported exposure to a fish kill or to fish with lesions. We found no pattern of abnormalities on medical, neurologic, neuropsychologic, or NES-2 evaluation. By history, one subject in each group met the EAS criteria, neither of whom had significant neuropsychological impairment when examined. Watermen from affected waterways had a significant reduction in visual contrast sensitivity (VCS) at the midspatial frequencies, but we did not identify a specific factor or exposure associated with this reduction. The cohorts did not differ in reported occupational exposure to solvents (qualitative) or to other neurotoxicants; however, exposure history was not sufficiently detailed to measure or control for solvent exposure. This small prevalence study in watermen, conducted 3 months after the last documented fish kill related to Pfiesteria, did not identify an increased risk of estuary-associated syndrome in those working on affected waterways. A significant difference between the estuary and ocean watermen was found on VCS, which could not be attributed to any specific factor or exposure. VCS may be affected by chemicals, drugs, alcohol, and several developmental and degenerative conditions; it has not been validated as being affected by known exposure to dinoflagellate secretions. VCS should be considered for inclusion in further studies, together with documentation or quantification of its potential confounders, to assess whether it has utility in relationship to dinoflagellate exposure.
Evaluation of cytokine production, activation marker and homing receptors in children with atopic dermatitis and atopic bronchial asthma*1
Authors: C. Antunez, M.J. Torres, C. Mayorga, J.L. Corzo, A. Vera, J.A. Cornejo-Garcia, A. Jurado, M. Blanca
Journal: Journal of Allergy and Clinical Immunology (2004)
ADVANCEMENT OF SURGERY.A Paper Read before the Vigo County Medical Society, April 1890.
Authors: JOHN E. LINK
Journal: JAMA (1893)

Why I should have been selected to read a paper to the Society on the "Advancement of Surgery" is incomprehensible to my mind, unless it was for the purpose of inducing me to post myself more thoroughly upon the literature of the subject. Sure it is, that I, probably of all the members, have paid less attention to the serial productions, as published in our overloaded journalism, than any other member here. And I think it is a well understood fact, that I read less of our periodical literature, as well as our secular papers, than any other member of this community. What has stood the test of ten years' popular favor becomes a part of our texts; and compared to-day with what has been introduced as novel and good, not one-tenth part bears the test of the decade. For this reason I have declined to place any of my
Drug companies' lobbying of ministers has little effect on NICE
Authors: Andrew Jack
Journal: BMJ (2006)

Aggressive lobbying of government ministers by drug companies seeking to overturn the judgments of the body that advises on the use of treatments by the NHS in England and Wales has had little effect on its decisions.

Minutes of civil service meetings obtained by the Guardian (Sep 28, p 1) under freedom of information laws show that during the eight months to May this year senior executives from …
THE BUBO PLAGUE IN CHINA, WITH A BRIEF ACCOUNT OF THE GREAT PLAGUE OF LONDON.
Authors: BURNSIDE FOSTER
Journal: JAMA (1894)

Although the possibility of there being in this country an epidemic of this terrible disease is a very remote one, it would not be at all surprising if an occasional case should be brought to the Pacific coast from China, where it has been raging so recently, and where it still exists. In view of these facts I have thought that some account of this, by far the most fatal and horrible of all epidemic diseases might be of interest—as well from an historical as from a medical point of view. The first extensive epidemic of the plague, of which history has recorded any definite account, occurred in the sixth century, A. D., and is usually described as the Plague of Justinian, since it existed during nearly the whole of that emperor's reign. Although there are some discrepancies in the various accounts which I have consulted, the epidemic seems to have
The open reading frames in the 3' long terminal repeats of several mouse mammary tumor virus integrants encode V beta 3-specific superantigens.
Authors: A M Pullen, Y Choi, E Kushnir, J Kappler, P Marrack
Journal: The Journal of Experimental Medicine (1992)

Mice expressing the minor lymphocyte stimulation antigens, Mls-1a, -2a, or -3a, singly on the B10.BR background have been generated. Mls phenotypes correlate with the integration of mouse mammary tumor viruses (MTV) in the mouse genome. The open reading frames within the 3' long terminal repeats of the integrated MTVs 1, 3, 6, and 13 encode V beta 3-specific superantigens. Sequence data for these viral superantigens is presented, indicating that it is the COOH-terminal portion of the viral superantigen that interacts with the T cell receptor V beta element.
Scleroderma and erosive polyarthritis: a disease entity?
Authors: R D Armstrong, T Gibson
Journal: Annals of the Rheumatic Diseases (1982)

We describe 4 patients with scleroderma in whom a major clinical feature was a deforming, erosive polyarthritis accompanied by positive tests for rheumatoid factor. In all but 1 case the skin involvement preceded joint symptoms, and in some cases there was evidence of systemic involvement. This destructive arthritis may represent the coexistence of 2 diseases or an extreme form of the inflammatory arthritis seen in scleroderma. Alternatively, the clinical presentation may represent an 'overlap syndrome' with features of both scleroderma and rheumatoid arthritis.
Electrophysiological Effects of Dofetilide in an In Vitro Model of “Border Zone” Between Normal and Ischemic/Reperfused Myocardium
Authors: René Rouet, Sandra Picard, Christian Libersa, Mathieu Ghadanfar, Colin Alabaster, Jean-Louis Gérard
Journal: Circulation (2000)

Background —To evaluate both class III activity and antiarrhythmic action of dofetilide at the level of the “border zone,” we investigated its electrophysiological effects on guinea pig ventricular strips submitted partly to normoxia (normal zone, NZ) and partly to simulated severe ischemia, then reperfusion (altered zone, AZ). Methods and Results —Because of the differential class III effects of dofetilide in normal and ischemic regions, the dispersion of the action potential duration at 90% repolarization (APD 90 ) between NZ and AZ was reduced by 5 nmol/L of drug during early ischemia (at 10 minutes, APD 90 NZ/APD 90 AZ was 1.68±0.22 versus 2.82±0.17 in control, P &lt;0.05), whereas 50 nmol/L dofetilide worsened it during late ischemia (at 30 minutes, APD 90 NZ/APD 90 AZ was 4.62±0.76 versus 2.57±0.21 in control, P &lt;0.05). Concomitantly, dofetilide at 5, 10, and 50 nmol/L abolished the early extrastimulus (ES)-induced arrhythmias, and at 10 and 50 nmol/L, it significantly enhanced the incidence of late spontaneous repetitive responses (in 86% and 75% of preparations treated with 10 and 50 nmol/L, respectively, versus 25% in control, P &lt;0.05). During reperfusion, dofetilide at 5, 10, and 50 nmol/L exhibited concentration-dependent class III effects, as it did in the NZ, and did not modify the incidence of spontaneous arrhythmias. Conclusions —Dofetilide 5 nmol/L decreased APD 90 dispersion between NZ and AZ and reduced the early ES-induced arrhythmias. However, dofetilide 50 nmol/L increased APD 90 dispersion, and at 10 and 50 nmol/L, it increased the late spontaneous arrhythmias.
Splenic function in sickle cell anemia patients in Qatif, Saudi Arabia
Authors: Ali H. Al-Jam'a, Ibrahim A. Al-Dabbous, Sundara Krishna Chirala, Hussain Al-Majid, Jameela Al-Ali
Journal: American Journal of Hematology (2000)

A prospective study was conducted to study the splenic function among sickle cell anemia (SCA) patients in Qatif (Eastern Province of Saudi Arabia). Seventy-seven patients (30 children and 47 adults aged 2-57 years) were included. (99m)Tc stannous colloid liver-spleen scan was done for each patient during steady state. The splenic function was graded from 0 to 4 in relation to liver uptake. Seventy percent of our patients showed evidence of splenic hypofunction, and most of them (83%) had severe hyposplenism. Up to the age of 4 years, only 17% of the children showed evidence of functional hyposplenism, but by the age of 10 years >50% were hyposplenic. Most of the hyposplenic children had functional hyposplenism, whereas only one-third of hyposplenic adults had autosplenectomy. There was no effect of level of HbF on the frequency of hyposplenism, but on the other hand low MCV seems to be protective against hyposplenism. A significant number of adult SCA patients have clinically enlarged spleens, and almost a third have normally functioning spleens. Because of the low prevalence of hyposplenism in children younger than 4 years of age, routine penicillin prophylaxis is probably not indicated in this population, an issue which needs further evaluation.
Possibility of BSE in sheep causes alarm
Authors: J. Warden
Journal: BMJ (1998)

The British government is coming under pressure to order surveillance of sheep to see if flocks are infected with bovine spongiform encephalopathy (BSE). Professor Jeffrey Almond, a member of the government's Spongiform Encephalopathy Advisory Committee (SEAC), spoke this week of a “distinct possibility” that BSE could be found in sheep and recommended more extensive research.

Professor Almond, a virologist and professor of microbiology at the University of Reading, is to head a new subcommittee of SEAC to produce specific recommendations for a programme of research. He was speaking on BBC radio's Farming Today after an article in Nature (1998;395:6-7) quoted a member of SEAC as saying that if BSE has passed into the sheep population “we could be facing a potential national emergency.”

Professor Almond says that the possibility remains that BSE was introduced into the …
DELIRIUM: A GAP IN PSYCHIATRIC TEACHING
Authors: MAX LEVIN
Journal: American Journal of Psychiatry (1951)

Delirium is a psychosis characterized (always) by disorientation, and (commonly) by restlessness, dullness, fear, hallucinations, and other mental symptoms. It is often, but not always, due to toxemia, clearing up when the toxemia has been corrected. It may also occur as a terminal event in the course of an organic dementia even when there has been no toxemia; in such cases it may go on for months and years, and is irreversible. The disorientation of delirium differs in nature from that seen occasionally in paranoid schizophrenia. The delirious man, unlike the schizophrenic, tends to mistake the unfamiliar for the familiar (mistaking, for example, hospital for home, and nurse for wife). His thoughts and actions follow the patterns of lifelong habit—something that applies to healthy people too. The difference is that the healthy man, with highest cerebral centers in good condition, is able to discern when a situation calls for a response out of the common groove. The delirious man, in contrast, has, from paralysis of the highest cerebral centers, lost this power of discrimination, and responds with habitual patterns of thought and action when they are no longer appropriate. In drug delirium it is advisable to discontinue the causative drug abruptly and completely. In the treatment of delirium it is unwise to use any drug that can itself cause delirium. Bromides and barbiturates are especially to be shunned.
Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo
Authors: Piotr S. Kowalski, Peter J. Zwiers, Henriëtte W.M. Morselt, Joanna M. Kuldo, Niek G.J. Leus, Marcel H.J. Ruiters, Grietje Molema, Jan A.A.M. Kamps
Journal: Journal of Controlled Release (2014)
Health-related quality of life in survivors of locally advanced breast cancer: an international randomised controlled phase III trial
Authors: Andrew Bottomley, Patrick Therasse, Martine Piccart, Fabio Efficace, Corneel Coens, Carolyn Gotay, Marzena Welnicka-Jaskiewicz, Louis Mauriac, Jaroslaw Dyczka, Tanja Cufer, Michail R Lichinitser, Jan H Schornagel, Herve Bonnefoi, Lois Shepherd
Journal: The Lancet Oncology (2005)
A new xenograft model of myeloma bone disease demonstrating the efficacy of human mesenchymal stem cells expressing osteoprotegerin by lentiviral gene transfer
Authors: N Rabin, C Kyriakou, L Coulton, O M Gallagher, C Buckle, R Benjamin, N Singh, J Glassford, T Otsuki, A C Nathwani, P I Croucher, K L Yong
Journal: Leukemia (2007)
Incorporating coordination dynamics into an evolutionarily grounded science of intentional change
Authors: Viviane Kostrubiec, J. A. Scott Kelso
Journal: Behavioral and Brain Sciences (2014)

Abstract We suggest the authors' endeavor toward a science of intentional change may benefit from recent advances in informationally meaningful self-organizing dynamical systems. Coordination Dynamics, having contributed to an understanding of behavior on several time scales – adaptation, learning, and development – and on different levels of analysis, from the neural to the social, may complement, if not enhance, the authors' insights.
Plasma Volume Expansion Resulting from Interference with Adrenergic Function in Normal Man
Authors: JOHN V. WEIL, CHARLES A. CHIDSEY
Journal: Circulation (1968)

Guanethidine was administered to 10 normal subjects in order to examine the effects of reduced adrenergic function on plasma volume. An increase in the plasma volume was observed averaging 21.4% after 1 week, and 12.1% and 13.1% after 2 and 3 weeks of drug administration. A similar change in plasma volume resulted when alphaadrenergic blockade was produced with phenoxybenzamine. These changes occurred in the absence of sodium retention and were associated with attenuation of forearm venous sympathetic reflexes and a rise in forearm venous compliance. The increase in venous compliance which was observed was proportional to the changes in plasma volume in these subjects. Thus, the sympathetic nervous system through its control of venous resistance may provide a means whereby the blood volume can be regulated.
Pituitary Abscess Following General Sepsis in a Diabetic Patient
Authors: Yiechul Jung
Journal: JAMA (1976)

SINCE Glinski<sup>1</sup>and Simmonds<sup>2</sup>in 1913 and 1914 described pituitary abscesses accompanying systemic bacterial infection there have been only two such reports in the world literature.<sup>3,4</sup> We now report the case of a patient with diabetes mellitus and fatal<i>Escherichia coli</i>septicemia in whom severe hypoglycemic reactions developed. An abscess of the pituitary gland was found on postmortem examination. <h3>Report of a Case</h3> A 47-year-old woman with a ten-year history of diabetes mellitus was admitted to the hospital because of agitation and disorientation. Her temperature was 38 C, pulse rate 120 beats per minute, and blood pressure 70/50 mm Hg. She had been taking 40 units of isophane insulin suspension daily, with good control of diabetes and without any history of hypoglycemia or ketoacidosis. On admission, blood glucose level was 400 mg/100 ml with glycosuria (3+ ) and albuminuria (3+ ), as well as many white blood cells (WBC)