The Prophylactic Treatment of Hemophilia B Leyden with Anabolic Steroids
Authors: ERNEST BRIËT
Journal: Annals of Internal Medicine (1985)

Brief Reports1 August 1985The Prophylactic Treatment of Hemophilia B Leyden with Anabolic SteroidsERNEST BRIËT, M. D., MERK C. WIJNANDS, M.D., JAN J. VELTKAMP, M.D.ERNEST BRIËT, M. D.Search for more papers by this author, MERK C. WIJNANDS, M.D.Search for more papers by this author, JAN J. VELTKAMP, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-2-225 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHemophilia B Leyden is an X-linked recessively inherited bleeding disorder that cannot be distinguished from severe cross-reactive material-negative hemophilia B in patients under 15 years of age. After puberty, however, the hemorrhagic symptoms diminish and the factor IX levels begin to rise (1, 2). Until now, the cases of two unrelated families with this disease have been reported: one in the Netherlands (1, 2) and one in Greece (Mandalaki T, Louizou C, Dimitriadou C. Haemophilia B Leyden in Greece. Presented at the 13th Congress of the World Federation of Hemophilia, Tel Aviv, Israel, 8-13 July 1979). The close association of...References1. VELTKAMPMEILOFREMMELTSVAN DER VLERKLOELIGER JJHDE. Another genetic variant of hemophilia B: haemophilia B Leyden. Scand J Haematol. 1970;7:82-90. CrossrefMedlineGoogle Scholar2. BRIËTBERTINAVAN TILBURGVELTKAMP ERNJ. Hemophilia B Leyden: a sex-linked hereditary disorder that improves after puberty. N Engl J Med. 1982;306:788-90. CrossrefMedlineGoogle Scholar3. NIESCHLAGMAUSSCOERTKICOVIC EJAP. Plasma androgen levels in men after oral administration of testosterone or testosterone undecanoate. Acta Endocrinol. 1975;79:366-74. CrossrefMedlineGoogle Scholar4. OVERBEEKDELVERDE VISSER GAJ. Pharmacological comparisons of anabolic steroids (ethylestrenol, nandrolone esters). Acta Endocrinol. 1961;39 (suppl 63):7-17. Google Scholar5. VELTKAMPDRIONLOELIGER JEE. Detection of the carrier state in hereditary coagulation disorders. Thromb Diath Haemorrh. 1968; 19:279-303. MedlineGoogle Scholar6. TAPPEINERHINTNERGLATZLWOLFF GHJK. Hereditary angiooedema: treatment with danazol: report of a case. Br J Dermatol. 1979;100:207-12. CrossrefMedlineGoogle Scholar7. MADANESFARBER AM. Danazol. Ann Intern Med. 1982;96:625-30. LinkGoogle Scholar8. GRALNICKRICK HM. Danazol increases factor VII and factor IX in classic hemophilia and Christmas disease. N Engl J Med. 1983; 308:1393-5. CrossrefMedlineGoogle Scholar9. GRALNICKMAISONNEUVESULTANRICK HPYM. Benefits of danazol treatment in patients with hemophilia A (classic hemophilia). JAMA. 1985;253:1151-3. CrossrefMedlineGoogle Scholar10. GAREWALCORRIGANDURIEJETERDAMIANO HJBMM. Effect of danazol on coagulation parameters and bleeding in hemophilia. JAMA. 1985;253:1154-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ERNEST BRIËT, M. D.; MERK C. WIJNANDS, M.D.; JAN J. VELTKAMP, M.D.Affiliations: University Hospital Leiden the Netherlands PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHemophilia B Leyden: Literature and Our DataProgressive increase in FIX level in males with haemophilia B Leyden and c.35G > A mutation in early childhood not related to androgen effectHemophilia B Leyden and once mysterious cis-regulatory mutationsMicrobial oxidation of anabolic steroidsSex significantly influences transduction of murine liver by recombinant adeno-associated viral vectors through an androgen-dependent pathwayThe molecular basis of haemophilia BSevere Factor VII Deficiency Due to a Mutation Disrupting a Hepatocyte Nuclear Factor 4 Binding Site in the Factor VII PromoterSevere Factor VII Deficiency Due to a Mutation Disrupting a Hepatocyte Nuclear Factor 4 Binding Site in the Factor VII PromoterTranscriptional Regulation of the Gene Coding for Human Protein CModerate hemophilia B leyden: Identification by polymerase chain reaction, sequencing, and oligomer restrictionBLEEDING DISORDERSMutationen in der 5′-flankierenden Region des Faktor-IX-GensBiology of Inherited Coagulopathies: Factor IXRecovery from Hemophilia B Leyden: An Androgen-Responsive Element in the Factor IX PromoterLiver-specific expression of the gene coding for human factor X, a blood coagulation factor.Haemophilia B Leyden arising de novo by point mutation in the putative factor IX promoter regionMolecular genetic analysis of a novel form of haemophilia a characterized by the variable expression of factor VIIIDisruption of a C/EBP binding site in the factor IX promoter is associated with haemophilia B 1 August 1985Volume 103, Issue 2Page: 225-226KeywordsHematology and oncologyHemophiliaHemophilia BHemorrhagePubertySteroids ePublished: 1 December 2008 Issue Published: 1 August 1985 PDF downloadLoading ...