tbuckley/cabot-search huggingface dataset:
Streptomycin Poisoning in Renal Failure
Authors: K. D. G. Edwards, H. M. Whyte
Journal: BMJ (1959)

Alcohols and inhaled anesthetics enhance the function of GABA<sub>A</sub> receptors containing α, β, and γ subunits. Molecular analysis has focused on the role of the α subunits; however, there is evidence that the β subunits may also be important. The goal of our study was to determine whether Asn265, which is homologous to the site implicated in the α subunit (Ser270), contributes to an alcohol and volatile anesthetic binding site in the GABA<sub>A</sub> receptor β<sub>2</sub> subunit. We substituted cysteine for Asn265 and exposed the mutant to the sulfhydryl-specific reagent octyl methanethiosulfonate (OMTS). We used two-electrode voltage-clamp electrophysiology in <i>Xenopus laevis</i> oocytes and found that, after OMTS application, GABA-induced currents were irreversibly potentiated in mutant α<sub>1</sub>β<sub>2</sub>(N265C)γ<sub>2S</sub> receptors [but not α<sub>1</sub>β<sub>2</sub>(I264C)γ<sub>2S</sub>], presumably because of the covalent linking of octanethiol to the thiol group in the substituted cysteine. It is noteworthy that this effect was blocked when OMTS was applied in the presence of octanol. We found that potentiation by butanol, octanol, or isoflurane in the N265C mutant was nearly abolished after the application of OMTS, suggesting that an alcohol and volatile anesthetic binding site at position 265 of the β<sub>2</sub> subunit was irreversibly occupied by octanethiol and consequently prevented butanol or isoflurane from binding and producing their effects. OMTS did not affect modulation or direct activation by pentobarbital, but there was a partial reduction of allosteric modulation by flunitrazepam and alphaxalone in mutant α<sub>1</sub>β<sub>2</sub>(N265C)γ<sub>2S</sub> receptors after OMTS was applied. Our findings provide evidence that Asn265 may contribute to an alcohol and anesthetic binding site.
163 GRANULOMATOUS PHLEBITIS AND PORTAL VEIN OBSTRUCTION AND IN A RABBIT MODEL OF ENDOTOXIN INDUCED NON-CIRRHOTIC PORTAL HYPERTENSION (EIPHT)
Authors: P. Sakhuja, I.R. Wanless, M.R. Rizvi, S.B. Roge, R. Gondal, S.K. Sarin
Journal: Journal of Hepatology (2009)
In Favor of Controlling Proven, but Not Probable, Causes of Cancer: Landrigan et al. Respond
Authors: Philip J. Landrigan, Carolina Espina, Maria Neira
Journal: Environmental Health Perspectives (2011)

and does not alter our conclusion that this meta-analysis provides support for an association between occupational exposure to benzene and increased risk of multiple myeloma, acute lymphocytic leukemia, and chronic lymphocytic leukemia (Vlaanderen et al. 2011).
Former BMA chairman leaves NHS GPs drop opposition to end point assessment of trainees Revised patient's charter promises shorter waiting times Consultants plan for sanctions over local pay Improvements announced for health promotion
Authors: L. Beecham
Journal: BMJ (1995)

# Former BMA chairman leaves NHS {#article-title-2}

Dr Jeremy Lee-Potter, chairman of the BMA council from 1990 to 1993, is to retire early from the NHS because he is disillusioned with the government's response to doctors' concerns about its policies on the NHS. Writing in this month's issue of BMA News Review Dr Lee-Potter says that the present government is so in the grip of political dogma that it will not respond to any approach from the profession. “We are faced with an intransigent and unpopular government which continues to trample on our professionalism and ignore our advice.”

He said that for three years he tried to reestablish a working relationship with the government. But he failed, and he believed that the present chairman, Dr Sandy Macara, would also fail because the political dogma was that all forms of central administration should be replaced wherever possible by markets.

“Cannot health secretary Virginia Bottomley and her colleagues see the dangers of subjugating the profession?” he asks. “Being a doctor is not the same as being a business executive or an advertising man or an industrial worker.”

Dr Lee-Potter says that neither Mrs Bottomley nor his successor are likely to be allowed to do anything radically sensible about any of the issues which have forced the profession into confrontation. For this reason he believes that a Labour government may offer the best hope for doctors and the NHS.

The minister for health, Mr Gerald Malone, said that Dr Lee-Potter was describing a health service that he did not recognise.

# GPs drop opposition to end point assessment of trainees {#article-title-3}

The General Medical Services Committee has reversed its decision taken a year ago that the proposals from the Joint …
Prevalence of Autoantibodies in a Group of Hereditary Angioedema Patients
Authors: S. Dortas Jr., S.O.R. Valle, S.A.P. Levy, A.T. Abe, R.P. Tortora, G.V. Pires, J.S. Papi, A.T. França
Journal: Journal of Allergy and Clinical Immunology (2011)
Changes in the distribution of laminin-5 during peri-implant epithelium formation after immediate titanium implantation in rats
Authors: Ikiru Atsuta, Takayoshi Yamaza, Masao Yoshinari, Satoya Mino, Tetsuya Goto, Mizuho A Kido, Yoshihiro Terada, Teruo Tanaka
Journal: Biomaterials (2004)
The Anatomy of a Suicide
Authors: Leston L. Havens
Journal: New England Journal of Medicine (1965)

It is because the physician must deal with situations involving so many independent variables that clinical medicine has remained an art even today — an art based on wisdom and skill derived from experience as much as on scientific knowledge and reasoning. The skill symbolized by the gold-headed cane was not mere charlatanism. It grew in no small part from the physician's awareness — even though ill defined and often subconscious — of the many factors which play a part in the causation and manifestations of disease. It was the fruit of the Hippocratic flowering. Far from being hypnotized by . . .
Who Determines Physician Effectiveness?
Authors: Paul J. Hershberger, Dean A. Bricker
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Distribution of D-Xylose in Sequestered Fluid Resulting in False-Positive Tests for Malabsorption
Authors: GEOBEL A. MARIN
Journal: Annals of Internal Medicine (1968)

Blood levels and urinary excretion of D-xylose, after a 25-g oral load, were determined in 20 patients with cirrhosis. In all patients blood levels of xylose were above normal, and in 15 patients without ascites the urinary excretion of xylose was normal. In the other five cirrhotic patients with ascites and in two additional patients with ascites due to tuberculous peritonitis, the urinary excretion of xylose was markedly reduced. All of these seven patients with ascites had xylose in the ascitic fluid up to 23 hr. These results indicate that low 5-hr urinary excretion of xylose occurs in subjects with ascites, leading to a false-positive test for malabsorption.
Restauro-G: A Rapid Genome Re-Annotation System for Comparative Genomics
Authors: Satoshi Tamaki, Kazuharu Arakawa, Nobuaki Kono, Masaru Tomita
Journal: Genomics Proteomics & Bioinformatics (2007)

Abstract Annotations of complete genome sequences submitted directly from sequencing projects are diverse in terms of annotation strategies and update frequencies. These inconsistencies make comparative studies difficult. To allow rapid data preparation of a large number of complete genomes, automation and speed are important for genome re-annotation. Here we introduce an open-source rapid genome re-annotation software system, Restauro-G, specialized for bacterial genomes. Restauro-G re-annotates a genome by similarity searches utilizing the BLAST-Like Alignment Tool, referring to protein databases such as UniProt KB, NCBI nr, NCBI COGs, Pfam, and PSORTb. Re-annotation by Restauro-G achieved over 98% accuracy for most bacterial chromosomes in comparison with the original manually curated annotation of EMBL releases. Restauro-G was developed in the generic bioinformatics workbench G-language Genome Analysis Environment and is distributed at http://restauro-g.iab.keio.ac.jp/ under the GNU General Public License.
Acute Hypercapnia Improves Indices of Tissue Oxygenation More than Dobutamine in Septic Shock
Authors: Zhen Wang, Fuhong Su, Alejandro Bruhn, Xin Yang, Jean-Louis Vincent
Journal: American Journal of Respiratory and Critical Care Medicine (2007)

Hypercapnia has similar hemodynamic effects to those of a dobutamine infusion and may have relevance in the management of septic shock.To compare the effects induced by hypercapnia with those of dobutamine in a clinically relevant model of septic shock.Fecal peritonitis was induced in 21 anesthetized, invasively monitored, mechanically ventilated female sheep. A combination of Ringer's lactate and 6% hydroxyethyl starch solution was titrated to maintain constant cardiac filling throughout the experiments. Two hours after feces spillage, animals were randomized to one of three groups (each, n = 7): (1) hypercapnia: carbon dioxide given to maintain partial pressure of carbon dioxide between 55 and 65 mm Hg throughout the experiment; (2) dobutamine: dobutamine infused intravenously (7 microg/kg/min); (3) control: no treatment. In the dobutamine and control groups, the partial pressure of carbon dioxide was kept between 35 and 45 mm Hg. All animals were monitored until spontaneous death.The animals in the hypercapnia group had significantly lower arterial pH than the other two groups (P < 0.05). Hypercapnic and dobutamine-treated animals developed significantly higher heart rate, cardiac index, and oxygen delivery, and lower lactate concentrations than control animals (P < 0.05). Hypercapnic animals had lower post mortem lung wet/dry ratio than the control animals (P < 0.05). The alveolar-arterial oxygen partial pressure difference and shunt fraction were significantly lower in hypercapnic animals than in the other groups (P < 0.05).In this clinically relevant ovine model of septic shock, hypercapnia had similar effects to dobutamine on hemodynamic variables and lactic acidosis. Hypercapnia improved tissue oxygenation and reduced lung edema formation more than dobutamine administration.
Selective Vacuolar Degeneration in Dystrophin-Deficient Canine Purkinje Fibers Despite Preservation of Dystrophin-Associated Proteins With Overexpression of Dp71
Authors: Nobuyuki Urasawa, Michiko R. Wada, Noboru Machida, Katsutoshi Yuasa, Yoshiki Shimatsu, Yoshito Wakao, Shigeki Yuasa, Toshiaki Sano, Ikuya Nonaka, Akinori Nakamura, Shin’ichi Takeda
Journal: Circulation (2008)

Background— Respiratory support therapy significantly improves life span in patients with Duchenne muscular dystrophy; cardiac-related fatalities, including lethal arrhythmias, then become a crucial issue. It is therefore important to more thoroughly understand cardiac involvement, especially pathology of the conduction system, in the larger Duchenne muscular dystrophy animal models such as dystrophic dogs. Methods and Results— When 10 dogs with canine X-linked muscular dystrophy in Japan (CXMD J ) were examined at the age of 1 to 13 months, dystrophic changes of the ventricular myocardium were not evident; however, Purkinje fibers showed remarkable vacuolar degeneration as early as 4 months of age. The degeneration of CXMD J Purkinje fibers was coincident with overexpression of Dp71 at the sarcolemma and translocation of μ-calpain to the cell periphery near the sarcolemma or in the vacuoles. Immunoblotting of the microdissected fraction showed that μ-calpain–sensitive proteins such as desmin and cardiac troponin-I or -T were selectively degraded in the CXMD J Purkinje fibers. Utrophin was highly upregulated in the earlier stage of CXMD J Purkinje fibers, but the expression was dislocated when vacuolar degeneration was recognized at 4 months of age. Nevertheless, the expression of dystrophin-associated proteins α-, β-, γ-, and δ-sarcoglycans and β-dystroglycan was well maintained at the sarcolemma of Purkinje fibers. Conclusions— Selective vacuolar degeneration of Purkinje fibers was found in the early stages of dystrophin deficiency. Dislocation of utrophin besides upregulation of Dp71 can be involved with this pathology. The degeneration of Purkinje fibers can be associated with the distinct deep Q waves in ECG and fatal arrhythmia seen in dystrophin deficiency.
Prevalence and spectrum of asthma in childhood.
Authors: D A Lee, N R Winslow, A N Speight, E N Hey
Journal: BMJ (1983)

All the 7 year old schoolchildren in North Tyneside were screened for wheeze with a questionnaire followed by selective clinical assessment: 9.3% of the children had had episodic wheeze within the past year and all those followed up subsequently responded to one or more of the drugs used for asthma. A further 1.8% had had similar symptoms since starting school, though they had not wheezed in the past year. Frequently of symptoms in the 11% of children with features of asthma varied widely and correlated with bronchial reactivity on histamine challenge, but it was not possible to separate children with frequent wheeze from asymptomatic controls by their response to histamine. It was concluded that all these wheezy children had symptoms of a common basic disorder and that they should all be treated as asthmatic.
Behcet's Syndrome and Acyclovir
Authors: T. SÖZEN
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 September 1984Behcet's Syndrome and AcyclovirT. SÖZEN, M.D., B. ATEŞ, M.D.T. SÖZEN, M.D.Search for more papers by this author, B. ATEŞ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-3-406_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A beneficial effect of acyclovir in a patient with neurologic Behçet's syndrome was reported by Resegotti and Pistone(1) in a recent issue. After reading their report, we tried a course of acyclovir in a patient with Behçet's syndrome who did not respond to conventional corticosteriod, cyclophosphamide, or indomethacin treatment, but the result was disappointing.A 28-year-old woman was found to have Behçet's syndrome in 1982. She was treated initially with cyclophosphamide, 150 mg/d, and then prednisone, 20 mg/d, was added. The dose was changed depending on her symptoms, but she was not free of vaginal or oral...Reference1. RESEGOTTIPISTONE LM. Acyclovir and Behçet's syndrome [Letter]. Ann Intern Med. 1984;100;319. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hacettepe Üniversitesi Ankara Turkey PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBehçet’s disease and complex aphthosisRECURRENT APHTHOUS STOMATITISBehçet's syndrome / AIDS / cerebral toxoplasmosis: an unusual associationRecurrent aphthous ulceration: Virological and immunological aspectsBehcet's disease in a patient with immunodeficiency virus infection.Neutrophilic Vascular DermatosesNeutrophilic vascular reactionsBehçe’s Disease and Complex Aphthosis 1 September 1984Volume 101, Issue 3Page: 406-406KeywordsCyclophosphamide ePublished: 1 December 2008 Issue Published: 1 September 1984 PDF downloadLoading ...
Subclass restriction and polyclonality of the systemic lupus erythematosus marker antibody anti-Sm.
Authors: R A Eisenberg, K Dyer, S Y Craven, C R Fuller, W J Yount
Journal: Journal of Clinical Investigation (1985)

Anti-Sm antibodies are highly specific markers for the diagnosis of systemic lupus erythematosus (SLE). This specificity suggests that the immunoregulation of these autoantibodies would reflect fundamental immune abnormalities in this disorder. As a clue to this immunoregulation, we have investigated the isotype distribution of anti-Sm antibodies by enzyme-linked immunosorbent assays. We have found that the anti-Sm response is markedly restricted to the IgG1 heavy chain isotype. On the other hand, the light chain distribution reflects that in normal serum, while isoelectric focusing analysis fails to show an oligoclonal pattern. The related specificity, anti-ribonucleoprotein, is also restricted to IgG1, while the SLE-specific antibody anti-double-stranded DNA is mostly IgG1 with a lesser contribution by IgG3. These results suggest that antinuclear antibodies that are strongly associated with SLE are produced by a T cell-dependent response, probably driven by antigen. The immunoregulation of the response to several autoantigens may be quite similar.
Feeding the Phenylketonuric
Authors: F. P. Hudson
Journal: BMJ (1964)

MBDIcRTISH L 1011 injected contrast media, with the risk of dis- placing a fragment towards the thorax, would only seem justified if the fragment could be palpated.'The damaged Braunile was subsequently connected to a disposable giving-set and transfusion under pressure simulated with the aid of a Martin's pump.After 2 minutes the cannula fractured 2 cm.from the tip and the distal portion shot off.The cause of the fracture remains uncertain.It seems un- likely in view of the position (away from a joint) and the short period of use (under 2 hours) that it could be fatigue.A manu- facturing fault, undetected on insertion, can- not be ruled out, but the possibility of the cannula's being nicked by the bevel of the needle on withdrawal seems the most probable cause.Practical safeguards should include great care in the inspection, positioning, and inser- tion of the Braunule, especially in the with- drawal of the needle.On removal of the cannula it should be examined and measured to ensure that it has been entirely recovered.The advisability of pressure-transfusion through such a unit must be open to question.The suggestion in a B.M.7.editorial' that plastic materials for intravascular insertion should contain radio-opaque material should be implemented.
Goodpasture's Syndrome
Authors: George D. Lundberg
Journal: JAMA (1963)

A patient presenting with a combination of pulmonary hemorrhage and glomerulonephritis was studied clinically and at autopsy. He demonstrated histologically similar fibrocellular lesions of glomeruli and alveoli suggesting a common pathogenesis in the kidneys and lungs. Previous infection with a Group A, Type 12 streptococcus was documented by serologic testing. Thirty-seven additional cases of Goodpasture's syndrome have been found in the literature, typifying the entity as a rapidly progressive, nearly uniformly fatal disease affecting predominantly young adult men. The frequency of reports of this entity has recently increased, probably representing increased recognition of the disease.
Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells
Authors: Zvi Ram, Kenneth W. Culver, Eric M. Oshiro, John J. Viola, Hetty L. DeVroom, Edward Otto, Zhifeng Long, Yawen Chiang, Gerard J. McGarrity, Linda M. Muul, David Katz, R. Michael Blaese, Edward H. Oldfield
Journal: Nature Medicine (1997)
Infantile colic. Association with lactose and milk intolerance
Authors: W. M. Liebman
Journal: JAMA (1981)

Intolerance to lactose and cow's milk protein was prospectively evaluated in 56 infants with apparent colic. A complete blood cell count, sedimentation rate, test for quantitative IgE level, radioallergosorbent test (performed in 15 patients), and at least three stool examinations for pH, presence of reducing substances, and occult blood were performed in 56 infants (46, appropriate size for gestational age; ten, small for gestational age) and results were within normal limits for age. This study suggests that tolerance to lactose and cow's milk protein does not have a significant role in infantile colic.
Harsh Russian winter takes an early toll
Authors: S. Jameson
Journal: BMJ (1995)

In Moscow 25 people have died and more than 100 others have been treated for frostbite during the first half of this month after an unusually early start to the long Russian winter. With night time temperatures plummeting to -15°C, those most at risk--homeless people and heavy drinkers--quickly succumbed to the bitter cold. According to a spokesman for the municipal health authority, all the victims so far this winter had been drinking heavily.

At Moscow's Paveletsky railway station, which is a regular haunt for homeless …
Carbon Beam Therapy Overcomes the Radiation Resistance of Uterine Cervical Cancer Originating from Hypoxia
Authors: Takashi Nakano, Yoshiyuki Suzuki, Tatsuya Ohno, Shingo Kato, Michiya Suzuki, Shinroku Morita, Shinichiro Sato, Kuniyuki Oka, Hirohiko Tsujii
Journal: Clinical Cancer Research (2006)

Abstract Purpose: High linear energy transfer (LET) particles are believed to decrease tumor radiation resistance originating from hypoxia. However, no proof of this effect has been provided by clinical trials and related clinical research. Hence, we investigated the radiation biological aspects of high LET carbon beam therapy on cervical cancer. Experimental Design: This study involved 49 patients with stage IIIb bulky and stage IVa cervical cancer treated with high LET carbon beams between October 1995 and June 2000. Oxygen partial pressure (pO2) was measured by using a needle-type polarographic oxygen electrode. Results: The 4-year disease-free survival rates of patients with pO2 ≤ 20 mm Hg (hypoxic tumor) and pO2 &amp;gt; 20 mm Hg (oxygenated tumor) before treatment were 37% and 21%, respectively. The local control rates of hypoxic and oxygenated tumors before treatment were 58% and 54%, respectively. The disease-free survival rates of hypoxic and oxygenated tumors assessed by oxygen status at the 5th day of irradiation were 33% and 32%, respectively. The local control rates of hypoxic and oxygenated tumors at the 5th day were 60% and 58%, respectively. There was no significant prognostic difference between hypoxic and oxygenated tumors. Conclusion: The similar disease-free survival and local control rates between hypoxic and oxygenated tumors before and during treatment indicated that the role of the tumor oxygenation status was not so important in local control in carbon beam therapy. These results indicated that high LET carbon beam irradiation might reduce the radiation-resistant nature stemming from tumor hypoxia.