tbuckley/cabot-search huggingface dataset:
Doctors should have to be accredited to support whiplash claims, say MPs
Authors: I. Torjesen
Journal: BMJ (2013)

MPs have backed government proposals to set up panels of accredited medical practitioners to provide medical reports in relation to whiplash claims in an attempt to reduce the amount of money paid out in fraudulent claims.

The backing came in a report by the Commons transport select committee on the cost of whiplash claims to the insurance industry.1 The committee agreed with the Ministry of Justice’s proposals2 that medical reports should be provided only by medical practitioners belonging to accredited panels, which included doctors but also other health professionals such as physiotherapists.

The report said that there were concerns that doctors providing reports under the current system may be biased towards who was paying them for the work, and that GPs in particular “may find it difficult to decline to certify an alleged injury because of the relationship that has built …
The social organization of sexuality
Authors: H. W. Haverkos
Journal: JAMA (1995)

To the Editor.  —The National Health and Social Life Survey on adult sexual behavior in the United States was released recently. 1-3 The report is based on interviews of 3432 men and women aged 18 to 59 years residing in randomly selected households across the country. The goals of the survey were to present a comprehensive and scientific picture of sexual behavior, guide further research, and target health and social services.  However, the potential for misinterpretation of this information is great, particularly in planning and allocating resources related to sexually transmitted diseases such as the human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). One prominent finding of the survey was that approximately 80% of adults reported no or one sexual partner in the year before the interview, and approximately 3% of men and 2% of women reported any homosexual or bisexual activity during the same period. From these data,
Abstract 79: Immunomodulation in response to radiation-induced lung injury.
Authors: Federica Cappuccini, Florian Wirsdörfer, Malagorzata Drabczyk, Therese Eldh, Ali Sak, Verena Jendrossek
Journal: Cancer Research (2013)

Abstract Introduction. Pneumonitis and fibrosis constitute dose-limiting side effects of thorax and whole body irradiation. Although several novel disease biomarkers have been described during recent years, the cellular and molecular factors responsible for disease initiation and progression are still not sufficiently understood. Here, we characterized local and systemic changes in the immune cell compartment in response to radiation-induced lung injury and defined the role of lymphocytes for fibrosis development in a murine model. Material and methods A single dose of hemithorax or whole thorax irradiation (15 Gy) was applied on C57BL/6 wild type mice (WT) or immunodeficient RAG-2-/- mice. Mice were sacrificed at defined time points and lungs were isolated for histological and immunohistochemical analysis as well as immune cell phenotyping. Moreover, immune cells were isolated from spleen, blood and cervical lymph nodes and also characterized by flow cytometry. Bronchioalveolar lavage fluid was collected for determination of cytokine levels. Results and discussion. Whole thorax irradiation triggered time-dependent changes in the composition and activation state of immune cells isolated from the lung tissue. These changes were paralleled by specific alterations in the cytokines present in the bronchoalveolar lavage fluid. In WT mice whole thorax irradiation with 15 Gy led to a time-dependent increase in collagen deposition and lung fibrosis. Irradiated RAG-2-/- mice showed an earlier onset of collagen deposition and an increased number of fibrotic foci in the lung when compared to WT mice. Conclusion. Thorax irradiation triggers local and systemic changes in the composition and the activation state of immune cells. The increased sensitivity of RAG-2-/- mice to radiation-induced fibrosis suggests a role of mature lymphocytes in the suppression of fibrotic changes. An improved understanding of the contribution of specific immune cells to the pathogenic process in the lung may open novel routes to prevent or treat radiation-induced pneumopathy. Citation Format: Federica Cappuccini, Florian Wirsdörfer, Malagorzata Drabczyk, Therese Eldh, Ali Sak, Verena Jendrossek. Immunomodulation in response to radiation-induced lung injury. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 79. doi:10.1158/1538-7445.AM2013-79
Emerging Roles of MUC4 in Cancer: A Novel Target for Diagnosis and Therapy
Authors: Ajay P. Singh, Pallavi Chaturvedi, Surinder K. Batra
Journal: Cancer Research (2007)

Abstract The MUC4 mucin is a transmembrane glycoprotein that is implicated in the pathogenesis of pancreatic cancer and is aberrantly expressed in many other epithelial carcinomas. Recent studies suggest its significant potential as a clinical tool for cancer diagnosis and prognosis. MUC4 modulates HER2/ErbB2 signaling and is a determinant of therapeutic outcome of Herceptin-based therapy, which further indicates its prospective usefulness in cancer therapy and treatment planning. [Cancer Res 2007;67(2):433–6]
SPASTIC DIPLEGIA FOLLOWING PERTUSSIS.
Authors: J. H. W. RHEIN
Journal: JAMA (1905)

<h3>History.</h3> —The patient, a girl of 30 months, was brought to the clinic for nervous diseases at the St. Agnes Hospital in February, 1903. The mother stated that 8 months previously (May, 1902) the child had contracted pertussis, which lasted for 3 months. At the end of the first month of the disease the patient began gradually to lose the power of walking. Her mother first noticed that she became awkward, stumbled easily, and was very uncertain on her feet. By degrees the inability to walk increased until at the end of 4 months she could not walk unassisted. About this time the mother noticed that the child had nystagmus, but she had noted no other symptom until she brought her to the clinic 4 months later. <h3>Family History.</h3> —The family history of the child was excellent. The parents were healthy young people, and there was no history of nervous
In vivo effects of polyunsaturated, monounsaturated, and saturated fatty acids on hepatic and peripheral insulin sensitivity
Authors: Sandra Pereira, Danna M. Breen, Anthony E. Naassan, Penny Y.T. Wang, Hiroshi Uchino, I. George Fantus, André C. Carpentier, Roger Gutierrez-Juarez, David N. Brindley, Tony K.T. Lam, Adria Giacca
Journal: Metabolism (2014)
Prevention of Injuries to Children
Authors: Don R. King
Journal: JAMA (1983)

To  Editor.—  As a pediatrician, I do not wish to seem opposed to anything that will improve  care of children. However, as a father, taxpayer, and primary care medical provider, I believe that  emphasis of Dr Haller's comments (1983;249:47) misses  mark if he is attempting to point  way to  best total care of children. His focus as a highly trained, subspecialized surgeon allows him to recognize trauma as  leading cause of death in children but omit  fact that the scene of such trauma is our nation's highways. He points out that 80% of  multiple injuries in young children are from blunt-impact trauma but omits  fact that this overwhelmingly involves motor vehicles. His proposals for improving  care of children include organizing transports (helicopters?), improving diagnostic facilities (computed tomographic scanner in  examination room), and having available pediatricians, pediatric surgeons, and
Hepatic Dysfunction Following Bypass Operation
Authors: Seyed N. Moussavian
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Ames and colleagues have advocated the use of parenteral nutrition in the treatment of hepatic dysfunction following jejunoileal bypass for morbid obesity (235:1249, 1976). I would like to make some suggestions related to the cause of hepatic complications following bypass operation. Although choline deficiency has been shown to be involved in the development of fatty liver in rats,<sup>1</sup>it has not been shown to be a causative factor in human fatty liver. Moreover, exact mechanisms by which protein deficiency causes fatty liver in man and experimental animals are not clear.<sup>2</sup>Also, the suggestion of the authors that "breakdown of ingested choline by bacterial overgrowth in the bypassed intestine [occurs]" is not clear, especially since, with end-to-end anastomosis (which their patient had), reflux of intestinal contents into the bypassed segment of intestine is unlikely. Regarding the use of parenteral nutrition in bypass patients, none of the
The impact of NHS resource allocation policy on health inequalities in England 2001-11: longitudinal ecological study
Authors: B. Barr, C. Bambra, M. Whitehead
Journal: BMJ (2014)

<b>Objective</b> To investigate whether the policy of increasing National Health Service funding to a greater extent in deprived areas in England compared with more affluent areas led to a reduction in geographical inequalities in mortality amenable to healthcare. <b>Design</b> Longitudinal ecological study. <b>Setting</b> 324 lower tier local authorities in England, classified by their baseline level of deprivation. <b>Intervention</b> Differential trends in NHS funds allocated to local areas resulting from the NHS resource allocation policy in England between 2001 and 2011. <b>Main outcome measure</b> Trends in mortality from causes considered amenable to healthcare in local authority areas in England. Using multivariate regression, we estimated the reduction in mortality that was associated with the allocation of additional NHS resources in these areas. <b>Results</b> Between 2001 and 2011 the increase in NHS resources to deprived areas accounted for a reduction in the gap between deprived and affluent areas in male mortality amenable to healthcare of 35 deaths per 100 000 population (95% confidence interval 27 to 42) and female mortality of 16 deaths per 100 000 (10 to 21). This explained 85% of the total reduction of absolute inequality in mortality amenable to healthcare during this time. Each additional £10m of resources allocated to deprived areas was associated with a reduction in 4 deaths in males per 100 000 (3.1 to 4.9) and 1.8 deaths in females per 100 000 (1.1 to 2.4). The association between absolute increases in NHS resources and improvements in mortality amenable to healthcare in more affluent areas was not significant. <b>Conclusion</b> Between 2001 and 2011, the NHS health inequalities policy of increasing the proportion of resources allocated to deprived areas compared with more affluent areas was associated with a reduction in absolute health inequalities from causes amenable to healthcare. Dropping this policy may widen inequalities.
Calcific Constrictive Pericarditis
Authors: Dennis L. Desilvey
Journal: Annals of Internal Medicine (2000)

Letters7 November 2000Calcific Constrictive PericarditisDennis L. Desilvey, MDDennis L. Desilvey, MDUniversity of Virginia Health System; Charlottesville, VA 22908 (Desilvey)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-133-9-200011070-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Ling and colleagues' article on calcific constrictive pericarditis (1) provided some interesting insights into the clinical spectrum of calcific pericarditis. I am concerned, however, that the article may reflect an unfortunate trend in contemporary medicine and medical education. Nowhere did the article mention the physical examination of constrictive pericarditis or whether examination was used to determine further diagnostic studies. The authors did not discuss the classic findings of a pericardial knock, the Kussmaul sign, and the steep Y decent on the jugular pulse. I trust that a physical examination was done for these patients, but it is ...Reference1. Ling LH, Oh JK, Breen JF, Schaff HV, Danielson GK, Mahoney DW, et al . Calcific constrictive pericarditis: is it still with us? Ann Intern Med. 2000;132:444-50. LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Dennis L. Desilvey, MDAffiliations: University of Virginia Health System; Charlottesville, VA 22908 (Desilvey) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCalcific Constrictive Pericarditis: Is It Still with Us? Lieng H. Ling , Jae K. Oh , Jerome F. Breen , Hartzell V. Schaff , Gordon K. Danielson , Douglas W. Mahoney , James B. Seward , and A. Jamil Tajik Metrics 7 November 2000Volume 133, Issue 9Page: 748KeywordsHeart rateMedical education ePublished: 7 November 2000 Issue Published: 7 November 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Effect of Dutasteride on Prostate Biopsy Rates and the Diagnosis of Prostate Cancer in Men with Lower Urinary Tract Symptoms and Enlarged Prostates in the Combination of Avodart and Tamsulosin Trial
Authors: Claus G. Roehrborn, Gerald L. Andriole, Timothy H. Wilson, Ramiro Castro, Roger S. Rittmaster
Journal: European Urology (2010)
Turner Phenotype With Pelvic Kidney and Other Unusual Abnormalities
Authors: C. C. SCHULMAN
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Turner's syndrome with normal XX karyotype has been reported in the literature in a few patients only.<sup>1</sup> We wish to report a unique case of gonadal dysgenesis with a normal XX karyotype (sex-chromatin positive; chromosome studies of leukocyte culture and skin biopsy suggested a normal XX female karyotype). The patient presented the stigmata of a Turner phenotype associated with a solitary pelvic kidney. Our patient is a 17-year-old girl presenting, in addition to most of the usual stigmata of Turner phenotype (gonadal dysgenesis, short stature, webbed neck, shield chest, Kosowicz's sign), the following unusual associated abnormalities: complete absence of vagina and uterus, solitary pelvic kidney, hypoplasia of the entire right arm with alteration of the thumb joints, Klippel-Feil syndrome associated with webbing of the neck, and cervical ribs. The solitary pelvic kidney visualized by an intravenous pyeogram, was confirmed by radioisotopic scanning and perineoscopy which revealed
Radioiodination of human intrinsic factor
Authors: Iain L. Mackenzie, Robert M. Donaldson, Robert F. Schilling
Journal: Journal of Clinical Investigation (1969)

Human intrinsic factor (IF) saturated with (60)Co-labeled cyanocobalamin ((60)CoB(12)) was purified and then iodinated with (125)I to yield (125)I-labeled IF-(60)CoB(12) preparations of high specific activity. Sephadex G200 and DEAE-cellulose chromatography of the iodinated IF-(60)CoB(12) complex showed coincidence of the major (125)I and the (60)Co radioactivity peaks. During starch-gel electrophoresis (60)Co radioactivity from noniodinated and iodinated complexes migrated to the same extent while (125)I radioactivity from the iodinated complex migrated slightly further anodally than did the (60)Co radioactivity. After the iodinated complex was mixed with antibody to the IF-B(12) complex (antibody II) the (125)I and (60)Co radioactivity were: (a) precipitated in similar amounts by antiglobulin serum. (b) eluted coincidentally in the 19S region on Sephadex G200, and (c) excluded to the same extent from starch gel during electrophoresis. After equilibrium exchange of IF "blocking" antibody (antibody I) for (60)Co-vitamin B(12) on (125)I-labeled IF. (125)I radioactivity from the IF-antibody I complex: (a) was precipitated by antiglobulin serum, (b) was eluated in the 19S region on Sephadex G200 gel filtration, and (c) migrated slowly towards the anode on starch-gel electrophoresis. Urinary excretion of (60)Co radioactivity in pernicious anemia patients after oral administration of (60)Co-vitamin B(12) bound to freshly prepared (125)I-labeled IF was similar to that obtained with noniodinated intrinsic factor. These results show that iodination of IF-(60)CoB(12) complex does not markedly alter the chromatographic, electrophoretic, antigenic, or absorption-promoting properties of IF.
Genetic Ophthalmology and the Era of Clinical Care
Authors: Paul A. Sieving, Francis S. Collins
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Interactions between epithelial cells and dendritic cells in airway immune responses: lessons from allergic airway disease
Authors: J. Van Tongeren, S. M. Reinartz, W. J. Fokkens, E. C. De Jong, C. M. Van Drunen
Journal: Allergy (2008)

Micro‐organisms constantly invade the human body and may form a threat to our health. Traditionally, concepts of defence mechanisms have included a protective outer layer of epithelia and a vigilant immune system searching for areas where the integrity of the outer layer may be compromised. Instead of considering these elements as two independent mechanisms, we should be treating them as a single integrated system. This review will present and discuss the role of local immune‐competent cells and local epithelia in the recognition of potential pathogens and how the interaction between the two components may affect the initiation of the airway immune response. A concept emerges where airway mucosal dendritic cells act as integrators of both immunostimulatory and immunosuppressive signals that act within actively‐involved mucosal tissue.
Avid Accumulation of Ga-67 Citrate in Adenocarcinoma of Pancreas
Authors: MASATOSHI KUDO, KATSUJI IKEKUBO, MEGUMU HINO, AKIO TODO
Journal: Clinical Nuclear Medicine (1989)

Since its introduction in 1969, Ga-67 citrate has been employed as a tumor-seeking agent. The many experiences using Ga-67 citrate in the detection of malignant tumors have revealed that Ga-67 citrate normally does not accumulate in pancreatic cancer. This report presents a case of pancreatic cancer with very advanced systemic involvement that presented extremely increased accumulation of Ga-67 citrate. It is most unusual for Ga-67 citrate to accumulate so avidly in adenocarcinoma of the pancreas as well as in metastatic lesions, so that this avid Ga-67 accumulation could present a diagnostic dilemma for pancreatic cancer.
Intravascular Coagulation in Fresh-Water Submersion
Authors: THOMAS A. PORTS
Journal: Annals of Internal Medicine (1977)

We describe three cases of fresh-water drowning that were complicated by disseminated intravascular coagulation. Close observation for clinical bleeding, laboratory investigation of the coagulation system, and therapy for disseminated intravascular coagulation, when appropriate, seem indicated in patients hospitalized after fresh-water immersion.
Vaccination-induced cutaneous pseudolymphoma
Authors: Eve Maubec, Laure Pinquier, Manuelle Viguier, Frédéric Caux, Emmanuelle Amsler, Sélim Aractingi, Hafid Chafi, Anne Janin, Jean-Michel Cayuela, Louis Dubertret, François-Jérôme Authier, Hervé Bachelez
Journal: Journal of the American Academy of Dermatology (2005)
Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort
Authors: D. Inzitari, G. Pracucci, A. Poggesi, G. Carlucci, F. Barkhof, H. Chabriat, T. Erkinjuntti, F. Fazekas, J. M Ferro, M. Hennerici, P. Langhorne, J. O'Brien, P. Scheltens, M. C Visser, L.-O. Wahlund, G. Waldemar, A. Wallin, L. Pantoni
Journal: BMJ (2009)

<b>Objective</b> To assess the impairment in daily living activities in older people with age related changes in white matter according to the severity of these changes. <b>Design</b> Observational data collection and follow-up of a cohort of older people undergoing brain magnetic resonance imaging after non-disabling complaints. <b>Setting</b> 11 European centres. <b>Participants</b> 639 non-disabled older patients (mean age 74.1 (SD 5.0), 45.1% men) in whom brain magnetic resonance imaging showed mild, moderate, or severe age related changes in white matter (Fazekas scale). Magnetic resonance imaging assessment also included cerebral infarcts and atrophy. <b>Main outcome measure</b> Transition from no disability (defined as a score of 0 or 1 on the instrumental activities of daily living scale) to disability (score ≥2) or death over three year follow-up. Secondary outcomes were incident dementia and stroke. <b>Results</b> Over a mean follow-up period of 2.42 years (SD 0.97, median 2.94 years), information on the main outcome was available for 633 patients. The annual rate of transition or death was 10.5%, 15.1%, and 29.5%, respectively, for patients with mild, moderate, or severe age related changes in white matter (Kaplan-Meier log rank test P&lt;0.001). In a Cox model comparing severe with mild changes and adjusted for clinical factors of functional decline, the risk of transition to disability or death was more than twofold higher (hazard ratio 2.36, 95% confidence interval 1.65 to 3.81). The other predictors were age group, history of atrial fibrillation, and complaint of gait disturbances. The effect of severe changes remained significant independently of baseline degree of atrophy and number of infarcts. Incident stroke and dementia only slightly modified this effect. <b>Conclusion</b> The three year results of the LADIS study suggest that in older adults who seek medical attention for non-disabling complaints, severe age related changes in white matter independently and strongly predict rapid global functional decline.
Vaccines rarely cause adverse events, Institute of Medicine finds
Authors: B. Roehr
Journal: BMJ (2011)

Vaccines are safe to use and only rarely seem to result in adverse events, a committee of the US Institute of Medicine has concluded after an extensive review of the literature.

The study was commissioned for use by the National Vaccine Injury Compensation Program, a no fault compensation scheme created in 1988 to ensure an adequate supply of vaccines, to stabilise vaccine costs, and to establish and maintain an accessible and efficient forum for people found to have been injured by certain vaccines.

“We reviewed in detail more than 1000 peer reviewed articles from the scientific literature,” explained the committee’s chairwoman, Ellen Wright Clayton, director of the Center for Biomedical Ethics and Society at Vanderbilt …