Thrombo-Angiitis Obliterans: A Clinical Study of 200 Cases*
Authors: Edgar V. Allen, George E. Brown
Journal: Annals of Internal Medicine (1928)

Article1 February 1928Thrombo-Angiitis Obliterans: A Clinical Study of 200 CasesI. Etiology, Pathology, Symptoms, DiagnosisEDGAR V. ALLEN, M.D., GEORGE E. BROWN, M.D.EDGAR V. ALLEN, M.D.Search for more papers by this author, GEORGE E. BROWN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-8-535 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSpontaneous gangrene of the feet in middle-aged patients without arteriosclerosis has been known for many years. In 1879 Winiwarter reported the case of a man, aged fifty-seven, who had complained of rheumatic pains in the feet for twelve years. The pathologic changes were intimal proliferation, thrombosis and periarterial fibrosis; arteriosclerosis was absent. He designated the condition as a peculiar type of endarteritis and endophlebitis. Weiss, in 1895, and Manteuffel, in 1897, reported similar cases from which they concluded that the thrombosis was due to intimal changes of an arteriosclerotic nature. In 1879 Borchard reported five cases and favored the view...Bibliography(1) ALLENBROWN EVGE: Four cases of atypical vascular disease affecting the extremities. Med. Clin. N. Amer., 1926, x, 611-624. Google Scholar(2) ALLENBROWN EVGE: Erroneous diagnosis of Raynaud's disease in obliterative vascular disease (thrombo-angiitis obliterans). I. Vasomotor disturbances simulating Raynaud's disease. Am. Jour. Med. Sc., 1927, clxxiv, 319-329. CrossrefGoogle Scholar(3) ALLENBROWN EVGE: Erroneous diagnosis of Raynaud's disease in obliterative vascular disease (thrombo-angiitis obliterans). II. Thrombo-angiitis obliterans of the lower extremities with pulsating pedal arteries. Am. Jour. Med. Sc., 1927, clxxiv, 329-337. 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