Dietary Sugar in the Production of Hyperglyceridemia
Authors: PETER T. KUO
Journal: Annals of Internal Medicine (1965)

Article1 June 1965Dietary Sugar in the Production of HyperglyceridemiaPETER T. KUO, M.D., D.SC., DAVID R. BASSETT, M.D.PETER T. KUO, M.D., D.SC., DAVID R. BASSETT, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-6-1199 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe mechanism of production of primary hyperglyceridemia has not been satisfactorily defined. Primary hyperglyceridemia is currently differentiated into the "fat-induced," the "carbohydrate-induced," and the "mixed" forms, according to the manner in which the patient's plasma triglyceride level changes with varying proportions of fats and carbohydrates in the diet (1-4). A number of investigators (5-8) have shown that hyperglyceridemia can be induced in normal subjects and greatly exaggerated in hyperglyceridemic patients by high carbohydrate diets. However, it is well-known that people of the underdeveloped areas of the world, subsisting on high carbohydrate diets, apparently do not develop hyperglyceridemia. Up to the...References1. AHRENSHIRSCHOETTEFARQUHARSTEIN EHJKJWY: Carbohydrate-induced and fat-induced lipemia. Trans. Ass. Amer. Physicians 74: 134, 1961. MedlineGoogle Scholar2. FREDERICKSONONODAVIS DSKLL: Lipolytic activity of postheparin plasma in hyperglyceridemia. J. Lipid Res. 4: 24, 1963. CrossrefMedlineGoogle Scholar3. KUOBASSETT PTDR: Primary hyperlipidemias and their management. Ann. Intern. Med. 59: 495, 1963. LinkGoogle Scholar4. KNITTLEAHRENS JLEH: Carbohydrate metabolism in two forms of hyperglyceridemia. J. Clin. Invest. 43: 485, 1964. CrossrefMedlineGoogle Scholar5. HATCHABELLKENDALL FTLLEF: Effects of restriction of dietary fat and cholesterol upon serum lipids and lipoproteins in patients with hypertension. Amer. J. Med. 19: 48, 1955. CrossrefMedlineGoogle Scholar6. 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Robinette Foundation of Cardiovascular Research, Medical Clinics, Hospital of the University of Pennsylvania, Philadelphia, Pa.This study was supported by Research Career Development Awardee Grant 5-K3-AM-17,012-04 from the National Institutes of Health, U. S. Public Health Service, Bethesda, Md., grants from the American Heart Association, grant HE-08805-01 from the National Heart Institute, U. S. Public Health Service, Bethesda, Md., and grant 3-MO-l-FR-40 from the Clinical Research Center, Division of Research Facilities and Resources, National Institutes of Health, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to Peter T. Kuo, M.D., Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pa. 19104. 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