The Effect of Pyridoxine Deficiency on Carcinoid Syndrome
Authors: SALMAN GAILANI
Journal: Annals of Internal Medicine (1966)

Case Studies1 November 1966The Effect of Pyridoxine Deficiency on Carcinoid SyndromeStudy of a Case of Metastatic Bronchial Adenoma Treated with Induced Vitamin B6 DeficiencySALMAN GAILANI, M.B., AUGUSTINE L. ROQUE, M.D., JAMES F. HOLLAND, M.D.SALMAN GAILANI, M.B.Search for more papers by this author, AUGUSTINE L. ROQUE, M.D.Search for more papers by this author, JAMES F. HOLLAND, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-5-1044 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCarcinoid syndrome produced by metastatic bronchial adenoma is a rare but a well-established entity (1). Although the role of serotonin in the production of the carcinoid flush has been disputed recently (2, 3), elevated blood serotonin and increased excretion of its metabolite (5-hydroxyindolacetic acid (5-HIAA)) are still the most consistent measurable parameters in this condition. This paper presents the report of a patient with carcinoid syndrome caused by metastatic bronchial adenoma in whom definite symptomatic improvement was achieved by interference with serotonin synthesis. This interference was accomplished by production of a vitamin B6deficiency state during prolonged ingestion of a...References1. FRANKLIEBERTHAL HDMM: Carcinoid syndrome originating in bronchial adenoma. Arch. Intern. Med. (Chicago) 111: 791, 1963. CrossrefMedlineGoogle Scholar2. ROBERTSONPEARTANDREWS JIWSTM: The mechanism of facial flushes in the carcinoid syndrome. Quart. J. Med. 31: 103, 1962. MedlineGoogle Scholar3. LEVINESJOERDSMA RJA: Pressor amines and the carcinoid flush. Ann. Intern. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEffects of vitamin B6 metabolism on oncogenesis, tumor progression and therapeutic responsesClinical and biochemical studies of pyridoxine deficiency in patients with neoplastic diseases 1 November 1966Volume 65, Issue 5Page: 1044-1050KeywordsAdenomasAttentionDiarrheaDietExcretionIngestionMetabolitesProteinsPyridoxineSerotonin Issue Published: 1 November 1966 PDF DownloadLoading ...