tbuckley/cabot-search huggingface dataset:
ENTRANCE OF IODIZED OIL INTO THE VENOUS CIRCULATORY SYSTEM DURING UTEROGRAPHY
Authors: Geza Weitzner
Journal: JAMA (1935)

Intra-uterine injections of oily opaque substances for diagnostic and therapeutic purposes has become an ordinary everyday procedure in the hands of gynecologists. Very few untoward accidents or sequelae have been reported in the literature to date. The complications most frequently mentioned are peritoneal irritations, localized inflammatory processes, exacerbations of chronic or subacute inflammations in the pelvis, and iodism due to the resorption of the customary iodine ingredient of the injected liquid. The following is a report of an unusual accident occurring during an intra-uterine injection of iodized oil: M. L., a woman, aged 35, a Negress, was admitted to the Sterility Clinic of the Harlem Hospital, March 14, 1932. Her only complaint was her sterile marriage of six years' duration. A laparotomy, performed seven years before admission, revealed uterine myoma and left salpingitis with adhesions. Appendectomy, myomectomy and left salpingectomy were performed. She had periodic attacks of
Neuroendocrine Neoplasms and Their Cells of Origin
Authors: Howard L. Bleich, Emily S. Boro, Arthur S. Tischler, Marc A. Dichter, Bernard Biales, Lloyd A. Greene
Journal: New England Journal of Medicine (1977)

The body's homeostasis depends on the co-ordinated activity of the nervous system and the endocrine system. Although the physiologic co-operation of these two systems has long been recognized, neurons and endocrine cells are generally regarded as developmentally and functionally distinct. Neurons are thought to be of ectodermal origin and to function mostly as elongated conducting structures that directly control the behavior of other cells by transmission of electrical impulses and localized release of transmitter substances. Endocrine cells are thought to be mostly of nonectodermal origin and to control the behavior of other cells indirectly, by releasing hormones into the blood. . . .
Acute injuries in soccer, ice hockey, volleyball, basketball, judo, and karate: analysis of national registry data
Authors: U. M Kujala, S. Taimela, I. Antti-Poika, S. Orava, R. Tuominen, P. Myllynen
Journal: BMJ (1995)

To determine the acute injury profile in each of six sports and compare the injury rates between the sports.Analysis of national sports injury insurance registry data.Finland during 1987-91.621,691 person years of exposure among participants in soccer, ice hockey, volleyball, basketball, judo, or karate.Acute sports injuries requiring medical treatment and reported to the insurance company on structured forms by the patients and their doctors.54,186 sports injuries were recorded. Injury rates were low in athletes aged under 15, while 20-24 year olds had the highest rates. Differences in injury rates between the sports were minor in this adult age group. Overall injury rates were higher in sports entailing more frequent and powerful body contact. Each sport had a specific injury profile. Fractures and dental injuries were most common in ice hockey and karate and least frequent in volleyball. Knee injuries were the most common cause of permanent disability.Based on the defined injury profiles in the different sports it is recommended that sports specific preventive measures should be employed to decrease the number of violent contacts between athletes, including improved game rules supported by careful refereeing. To prevent dental injuries the wearing of mouth guards should be encouraged, especially in ice hockey, karate, and basketball.
Optically Traceable Solid Lipid Nanoparticles Loaded with siRNA and Paclitaxel for Synergistic Chemotherapy with In situ Imaging
Authors: Ki Hyun Bae, Jeong Yu Lee, Soo Hyeon Lee, Tae Gwan Park, Yoon Sung Nam
Journal: Advanced Healthcare Materials (2012)

Abstract Here, we report quantum dot‐incorporating solid lipid nanoparticles (SLNs) for anticancer theranostics with synergistic therapeutic effects of paclitaxel‐siRNA combination. The natural components of a low‐density lipoprotein (LDL) are reconstituted to produce LDL‐mimetic SLNs having a stable core/shell nanostructure incorporating quantum dots and paclitaxel within the lipid shell while anionic siRNA molecules are electrostatically complexed with the outer surface of SLNs. The produced SLN/siRNA complexes efficiently deliver both of paclitaxel and Bcl‐2 targeted siRNA into human lung carcinoma cells and exhibit synergistic anticancer activities by triggering caspase‐mediated apoptosis as determined by median effect plot analysis. Moreover, the strong fluorescence from quantum dots within SLNs enables in situ visualization of intracellular translocation of SLNs into cancer cells. Our study suggests that LDL‐mimetic SLNs can be utilized as a multifunctional and optically traceable nanocarrier for efficient anticancer theranostics.
Five Years Experience of Endoscopic Sphincterotomy in Japan: A collective study from 25 centres
Authors: M. Nakajima, M. Kizu, Y. Akasaka, K. Kawai
Journal: Endoscopy (1979)

Five years experience of Endoscopic Sphincterotomy (EST) in Japan has been analyzed in 468 collective cases from 25 centres. In the indication of EST, biliary tract stones were the main reason, and shared in 92.5% of the success of EST. Other applications were benign stenosis of the papilla of Vater, ascaris of the common bile duct and so on where these formed a small group in the indication of EST. Complete removal of stones had been observed spontaneously in 62.3% of the cases, and with the help of a basket or balloon catheter in 23.7% of successful EST. However, fourteen percent of EST had no effect on the delivery of gallstones. Complications during and after EST were observed in 8.5% of all cases where hemorrhage, pancreatitis and cholangitis were the main hazards. The mortality rate was 0.4%, a considerably low rate when the figure is simply compared with that of cases involving surgical intervention. Finally, the term of Endoscopic Sphincterotomy (EST) was proposed for this procedure because it proved to be the best expression of the actual procedure.
BOTTLE FEEDING AS A RISK FACTOR FOR CHOLERA IN INFANTS
Authors: RobertA. Gunn, RobertA. Pollard, AnnM. Kimball, JohnC. Feeley, RogerA. Feldman, SamirR. Dutta, P.P. Matthew, RifaatA. Mahmood, MyronM. Levine
Journal: The Lancet (1979)
Autumn Books: Cockles and muscles
Authors: P. Rhodes
Journal: BMJ (1987)

If you have only the most passing interest in words the best advice I can give you is to go out and buy B J Freedman's Just a Word, Doctor.The short pieces on a variety ofmedical words will be known to readers of the BMJ, where most of them have recently been published.But it is a delight to have them all between covers, for they merit another look for the pleasure they bring.The author, formerly consulting physician at King's College Hospital, has had a lot of fun tracing the origins of the words, which are in daily use in medicine, and he communicates it entertainingly, with obvious delight in his task.He makes brief forays into Latin, Greek, and modem languages for the light they throw on etymology, though this is always with a light touch and is not enough to frighten the ignorant reader away.One surprise is that Dr Freedman woiiders where are "the COCKLES of the heart."My ancient Shorter Oxford Dictionary suggests that they are explained "(1) by the likeness of a heart to a cockleshell (2) by the zool.name for the cockle, Cardium."I hesitate to offer this to the master, who must have thought of and discarded it.
Basic Diagnostic Radiology: An Introductory Textbook for Students in the Medical Sciences
Authors: Joseph E. Whitley
Journal: JAMA (1969)

Dr. Jones presents us with another approach to the study of roentgenology, a text arranged topographically. The 266-page text has a 5-page introduction and four chapters: chest, abdomen, appendicular area, and head and neck. Thus, both gastrointestinal abnormalities and myelography are discussed or illustrated in three of the four chapters. The normal roentgenographic anatomy of each area is described and pictured. Diseases were chosen to portray pathologic variations in density, size, contour, location, number, margination, and, where possible, function of the organ systems present in each area. The author mixes, in an interesting fashion, routine roentgenographic studies with common and exotic special procedures. No attempt is made at completeness in regard to diseases. Each chapter begins with a detailed summary and ends with lists of required, recommended, and additional reading. The 248 figures, generally excellent, are slightly uneven. Open and closed arrows and letters are used to point out and
Better integration could cut elderly patient bed days by 2.3 million a year, says King's Fund
Authors: I. Torjesen
Journal: BMJ (2012)

Hospitals in England would need 7000 fewer emergency beds if all hospitals reduced their rate of admission and average length of stay for the over-65s to the same levels as those of the best performing hospitals, shows a report by the healthcare think tank the King’s Fund.1

The report says that 2.3 million fewer bed days would be needed each year if all hospitals performed as well as those in the top quarter of primary care trust areas. Freeing up these beds would save £462m (€590m; $720m) a year, which could be reinvested in community and primary care services.

Every year there are two million unplanned admissions of patients aged over 65, …
Atypical pemphigus involving the esophagus with IgG antibodies to desmoglein 3 and IgA antibodies to desmoglein 1
Authors: Shigeki Inui, Masayuki Amagai, Shusaku Tsutsui, Saho Fukuhara-Yoshida, Satoshi Itami, Ichiro Katayama
Journal: Journal of the American Academy of Dermatology (2006)
“Thou hast counseled a better course than Thou hast permitted.”—St. Augustine
Authors: Daniel Bosch
Journal: Annals of Internal Medicine (2011)

Ad Libitum5 April 2011“Thou hast counseled a better course than Thou hast permitted.”—St. AugustineDaniel BoschDaniel BoschFrom Cambridge, MA 02139.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-7-201104050-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Through the windshield of a martini,Glazed with tiny knives—An icy, fern-like glade—I seeWhat, when the wounds heal, will become of me:The world is my womb, and a hysterectomyIs under way, and one of the surgeon's wives,Olive or Ginny—I wish she loved me—Flays me with tiny knives.Daniel BoschCambridge, MA 02139 Author, Article, and Disclosure InformationAffiliations: From Cambridge, MA 02139.Current Author Address: Daniel Bosch, 154 Auburn Street, 2W, Cambridge, MA 02139. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 April 2011Volume 154, Issue 7Page: 504KeywordsHysterectomyUterus ePublished: 5 April 2011 Issue Published: 5 April 2011 Copyright & PermissionsCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Benefits and Risks of Aspirin Use
Authors: Jennifer L. Lund, Til Stürmer, Henrik Toft-Sørensen
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Malignant Melanoma of the Skin and Mucous Membrane
Authors: E. DORINDA LOEFFEL
Journal: JAMA (1978)

This excellent book distills a lifetime of personal experience treating melanoma patients in surgical clinics in Sydney, Australia. It focuses with great sensitivity on the care of the whole patient, including suggestions for the handling of interviews with the patient and next of kin and for dealing with the dying melanoma patient suffering from feelings of sudden isolation and the fears of abandonment, pain, and indignity. The book raises many unanswered questions about melanoma, such as the following: Why is the incidence of melanoma among white races increasing all over the world? Why do women have a strikingly lower mortality from melanoma than men? Why do pigmented races have melanomas mainly on the nonpigmented soles of the foot and mucous membranes? Possible etiologic factors are discussed at length in a chapter contributed by Dr V. J. McGovern of Australia. Exposure to sunlight is probably the most important factor, accounting for
Effect of chronic ethanol feeding on rat hepatocytic glutathione. Compartmentation, efflux, and response to incubation with ethanol.
Authors: J C Fernandez-Checa, M Ookhtens, N Kaplowitz
Journal: Journal of Clinical Investigation (1987)

Hepatocytes from rats that were fed ethanol chronically for 6-8 wk were found to have a modest decrease in cytosolic GSH (24%) and a marked decrease in mitochondrial GSH (65%) as compared with pair-fed controls. Incubation of hepatocytes from ethanol-fed rats for 4 h in modified Fisher's medium revealed a greater absolute and fractional GSH efflux rate than controls with maintenance of constant cellular GSH, indicating increased net GSH synthesis. Inhibition of gamma-glutamyltransferase had no effect on these results, which indicates that no degradation of GSH had occurred during these studies. Enhanced fractional efflux was also noted in the perfused livers from ethanol-fed rats. Incubation of hepatocytes in medium containing up to 50 mM ethanol had no effect on cellular GSH, accumulation of GSH in the medium, or cell viability. Thus, chronic ethanol feeding causes a modest fall in cytosolic and a marked fall in mitochondrial GSH. Fractional GSH efflux and therefore synthesis are increased under basal conditions by chronic ethanol feeding, whereas the cellular concentration of GSH drops to a lower steady state level. Incubation of hepatocytes with ethanol indicates that it has no direct, acute effect on hepatic GSH homeostasis.
ENZYMATIC VARIANTS OF INFLUENZA VIRUS
Authors: Billie L. Padgett, Duard L. Walker
Journal: The Journal of Experimental Medicine (1958)

The rate of elution of the variant virus from chicken RBC is progressively decreased as the temperature of incubation is increased above 25°C. The activity of the parent virus, on the other hand, is increased as the temperature is increased up to 40°C. The major cause of the decreased activity of the variant at temperatures above 2S°C. is an inhibition of the variant enzyme rather than its inactivation. The activity of the variant enzyme is stimulated in the presence of strontium, calcium, and barium ions. Manganese has only a slight effect, and magnesium has no stimulatory effect on the elution of the variant virus. Elution of the variant at 37°C. is progressively inhibited at pH values above 7, while the parent virus is still active at pH 8. In the absence of calcium the variant enzyme, hemagglutinin, and infectivity are more heat labile than those of the parent virus. The addition of calcium increases the heat stability of all three properties of the variant, and in the presence of calcium the infectivity of the variant is as stable as that of the parent virus.
Superior Mesenteric Arteriovenous Fistula
Authors: John H. Brunner
Journal: JAMA (1973)

Arteriovenous fistulas in the mesenteric and portal systems are thought not to produce an increase in systemic blood flow. A case of traumatic superior mesenteric arteriovenous fistula caused an unexpectedly high cardiac output state. Selective angiography was useful in the confirmation and exact localization of the fistula. Hepatic vein wedge pressures in this case were at the upper limit of normal despite increased portal venous flow. Good correlation between portal venous pressure and wedged hepatic vein pressure in many entities causing portal hypertension may not necessarily exist in this hyperkinetic form.
BRISTOL GENERAL HOSPITAL: CASE OF EXCISION OF THE KNEE-JOINT: RECOVERY
Authors: R. W. Coe
Journal: BMJ (1856)

trmbling, she had expelld a coious stool, mixed with at least half a pint of dotted blood.I may end this brief report by alluding to one charac- teristic of the gastric ulcer in the aged, which is too im- portant to pss unnoticed: namely, its comparatively little isk of perforation.In the pathological Essay I have already cited, I have adduced reasons for the conclusion, that the general liability to perforation undergoes a con- stant decrease as life advances, even although the liability to the ulcer itself is just as constantly on the increase." The amount of these converse alterations of risk, we may regard as equal; and as being such, that from the age of 30 to that of 70, the risk of gastric ulcer gradually rises to double, while the risk of perforation from gastric ulcer gradually sinks to one-half, its former amount."To this estimate I may add one which was inadvertently omitted in the Essay referred to, and which better illus- trates the liability of the ulcer to perforate at different ages.Comparing the numbers of ulcers and of perforations in the two sexes indifferently, it would seem that, between the ages of 10 and 30, the proportion of perforations is that of two in every five ulcers; from 30 to 50, one in six; from 60 to 70, one in ten; and from 70 to 90, one in twenty-one ulcers only.Brook Street, Grosvenor Square, April 20th, 1856.* An instance was lately brought under my notice.in which a geutleman, of about 80 years of age, who had been healthy through the previous part of h lisfe, but had for the lit two yea suffered from smptons regarded as d t ic, died udden of copious hua .Thuecropsy sbnwed tf the bleeding csmta from an aery (probably the coronary) eroded by an u de Of the steanch.BRISTOL GENERAL HOSPITAL.
A Simple Test for Predicting Patients' Tolerance of Upper Gastrointestinal Endoscopy
Authors: S. D. Lodas, P. S. Tassios, S. A. Raptis
Journal: Endoscopy (1997)

See also: Topical Pharyngeal Anesthesia Improves Tolerance of Upper Gastrointestinal Endoscopy: A Randomized Double-Blind StudyEndoscopy 1995; 27(09): 659-664DOI: 10.1055/s-2007-1005783
THREE GREAT NATIONAL HEALTH PROBLEMS
Authors: OSCAR DOWLING
Journal: JAMA (1925)

The problems that I discuss are three of the most important that confront public health officers today. There is no implication that these three are the only ones, but in my opinion they are among the greatest. Nor are they new, though I should say that their solution or at least partial solution is imperative, and I think it will be admitted that a coordinated effort would do much to solve them. Concentration on a single objective is acknowledged to be the best method of attaining an end; dissipation of effort leads inevitably to lost motion and defeats success. Therefore the selection of three problems from among a great number simplifies matters; an attempt to consider more of them at a time would lead to confusion. I have chosen the problems of drug addiction, rabies and the venereal diseases. And while I might have taken tuberculosis in place of rabies,
A PATHOLOGIC CONTRIBUTION TO THE CONCEPT OF NEUROSOMATIC DETERIORATION IN EPILEPSY, WITH RECORD OF TWO CASES
Authors: Morgan B. Hodskins, Paul I. Yakovlev
Journal: American Journal of Psychiatry (1931)

These cases, clinically, seem quite different; however, both show the same essential features: epilepsy and the symptomatologic pattern of neurosomatic deterioration. In the first case—a child— deterioration developed more rapidly and was more destructive, in nine years leading to the ultimate stage of neurosomatic deterioration; namely, profound dementia and cerebral flexion paraplegia. In the second case—a man 66 years of age, with late epilepsy—the neurologic picture characteristic of neurosomatic deterioration developed more slowly, was not so dramatic, and the symptomatologic pattern was one that could be identified with the arteriosclerotic Parkinsonism. Pathologically, in both cases was found evidence of a primary vascular cerebral lesion which was, in the first case, an acute lesion—meningo-encephalitis; in the second case, a chronic lesion— cerebral-arteriosclerosis. In both cases the primary pathologic lesion was the starting point of the same chronic degenerative process affecting principally the frontal cortex (third layer) and basal ganglia (pallidum and peduncular-hypothalamic formation). This last chronic degenerative and atrophic secondary process appears to be the most plausible cause of the clinical symptoms of neurosomatic deterioration. The predominant localization of this process in the third layer of the cortex and in the pallidum appear to agree with the fundamental features of the clinical syndrome which was manifested by disturbances in the psychomotor sphere; namely, dementia and progressive rigidity.
THU0136 Acupuncture in the Treatment of Rheumatoid Arthritis: Results of A Randomized Controlled Trial
Authors: P. Mishra, V. Trivedi
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Acupuncture is commonly used by patients in India with chronic painful musculoskeletal disorders. There are, however, few well-designed studies of its efficacy. <h3>Objectives</h3> This study describes a randomized controlled trial to evaluate acupuncture as a useful treatment adjunct in the management of patients with rheumatoid arthritis (RA). <h3>Methods</h3> We conducted a prospective, partially blinded, controlled, randomized clinical trial of patients receiving true acupuncture compared with a control group of patients who received simulated acupuncture. All patients met American College of Rheumatology criteria for RA and had tried conservative symptomatic treatments other than acupuncture. All patients received 25 sessions over a period of 12 weeks. Seven acupuncture points were chosen. Primary outcome is the changes in the pain score. Secondary outcomes included the changes in the ACR core disease measures, DAS 28 score and the number of patients who achieved ACR 20 at week 12. The trial was conducted from May 2011 to August 2012. <h3>Results</h3> Fifty patients participated in the study: 25 in the acupuncture group and 25 in the control group. The number of tender joints was significantly reduced for the true acupuncture groups. Physician9s global score was also significantly reduced for the true group and patient9s global score was also significantly reduced for the true group compared with the control group during the study period (P=0.01). The largest difference in total scores was observed at 2 months of therapy. Fatigue and anxiety were the most significantly improved symptoms during the follow up period. However, activity and physical function levels did not change. Acupuncture was well tolerated, with minimal adverse effects. Detailed results will be presented. <h3>Conclusions</h3> : This study paradigm allows for controlled and blinded clinical trials of acupuncture. We found that acupuncture significantly improved symptoms of RA. Symptomatic improvement was not restricted to pain relief and was most significant for fatigue and anxiety. <h3>Disclosure of Interest</h3> : None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2199