Comparative Effects of Caloric Restriction and Total Starvation on Body Composition in Obesity
Authors: MICHAEL F. BALL
Journal: Annals of Internal Medicine (1967)

Article1 July 1967Comparative Effects of Caloric Restriction and Total Starvation on Body Composition in ObesityMICHAEL F. BALL, M.D., JOHN J. CANARY, M.D., F.A.C.P., LAURENCE H. KYLE, M.D., F.A.C.P.MICHAEL F. BALL, M.D., JOHN J. CANARY, M.D., F.A.C.P., LAURENCE H. KYLE, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-1-60 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTotal starvation as a treatment of obesity was introduced by Bloom (1), popularized by Duncan and associates (2, 3), and elaborated upon by Drenick and colleagues (4, 5). An increasing number of reports concerning metabolic effects of this therapeutic approach are appearing (6-10), but only limited data exist concerning the effects of starvation on basic body constituents (11, 12). This study involves the use of densitometric, volume-distribution, and balance techniques to measure change in total body fat and lean body mass during both caloric restriction and total starvation.The first study, involving five obese patients, was designed to compare loss...References1. BLOOM WL: Fasting as an introduction to the treatment of obesity. Metabolism 8: 214, 1959. MedlineGoogle Scholar2. DUNCANJENSONFRASERCRISTOFORI GGWKRIFC: Correction and control of intractable obesity. Practicable application of intermittent periods of total fasting. JAMA 181: 309, 1962. CrossrefMedlineGoogle Scholar3. DUNCANJENSONCRISTOFORISCHLESS GGWKFCGL: Intermittent fasts in the correction and control of intractable obesity. Amer. J. Med. Sci. 245: 515, 1963. CrossrefGoogle Scholar4. DRENICKSWENDSEIDBLAHDTUTTLE EJMEWHSG: Prolonged starvation as treatment for severe obesity. JAMA 187: 100, 1964. CrossrefMedlineGoogle Scholar5. 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BENOITMARTINWATTEN FLRLRH: Changes in body composition during the weight reduction in obesity. Balance studies comparing effects of fasting and a ketogenic diet. Ann. Intern. Med. 63: 604, 1965. LinkGoogle Scholar12. BOLINGERLUKERTBROWNGUEVARASTEINBERG REBPRWLR: Metabolic balance of obese subjects during fasting. Arch. Intern. Med. (Chicago) 118: 3, 1966. CrossrefMedlineGoogle Scholar13. WERBINCHAIKOFFIMADA HILMR: Rapid sensitive method for determining H3-water in body fluids by liquid scintillation spectrometry. Proc. Soc. Exp. Biol. Med. 102: 8, 1959. CrossrefMedlineGoogle Scholar14. BALLMELONIDIAZVASQUEZCANARY MFCRMJAJJ: Nitrogen measurement in biologic fluids and bone by an automatic Dumas technique. Anal. Biochem. 16: 343, 1966. CrossrefMedlineGoogle Scholar15. CLIVEBALLMELONIWERDEINCANARYKYLE DMFCREJJJLH: Modifications of helium dilution method of measuring human body volume. J. Lab. Clin. Med. 66: 841, 1965. MedlineGoogle Scholar16. SIRI WE: Body Composition from Fluid Spaces and Density: Analysis of Methods. University of California Research Laboratory Publication no. 3349. Donner Laboratory of Biophysics and Medical Physics, University of California, Berkeley, March 1956. Google Scholar17. KYLEWERDEINCANARYPACHUTA LHEJJJB: Measurement of change in total body fat. J. Clin. Invest. 38: 1475, 1959. CrossrefMedlineGoogle Scholar18. EDELMANBROOKSMOORE ISLFD: Endogenous fat metabolism studied by heavy water dilution and nitrogen balance. J. Clin. Invest. 31: 626, 1952. Google Scholar19. KYLE LH: Physiological considerations in study of body composition. Ann. N. Y. Acad. Sci. 110: 679, 1963. CrossrefMedlineGoogle Scholar20. BLONDHEIMKAUFMANN SHNA: Comparison of fasting and 800-1000 calorie diet in treatment of obesity. Lancet 1: 250, 1965. CrossrefMedlineGoogle Scholar21. DRENICK EJ: Obesity: weight reduction and body composition (letters and comments). Ann. Intern. Med. 64: 1148, 1966. LinkGoogle Scholar22. REIFENSTEINALBRIGHTWELLS EGFSL: The accumulation, interpretation and presentation of data pertaining to metabolic balance; notably those of calcium, phosphorus and nitrogen. J. Clin. Endocr. 5: 367, 1945. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MICHAEL F. BALL, M.D.; JOHN J. CANARY, M.D., F.A.C.P.; LAURENCE H. KYLE, M.D., F.A.C.P.Affiliations: Washington, D. C.From the Department of Medicine, Georgetown University School of Medicine and the Georgetown University Hospital, Washington, D. C.This study was supported in part by grants AMO-2756 and TIAM-5041, the National Institute of Arthritis and Metabolic Diseases, the National Institutes of Health, Bethesda, Md., by research grant RD 2224-M, the Vocational Rehabilitation Administration, U. S. Department of Health, Education, and Welfare, Washington, D. C., by general research support grant FR 5360, the Division of Research Facilities and Resources, the National Institutes of Health, by grants from the Life Insurance Medical Research Fund, Rosemont, Pa., and by grants from the Washington Heart Association. This work was conducted in part through the Georgetown University Clinical Study Unit supported by grant FR-60, the National Institutes of Health.Dr. Ball was a Postdoctoral Research Fellow supported by grant F2 AM 19, 611, the National Institute of Arthritis and Metabolic Diseases, the National Institutes of Health, and now is a Research and Development Awardee of the American Diabetes Association, New York, N. Y.Requests for reprints should be addressed to Michael F. Ball, M.D., Department of Medicine, Georgetown University Hospital, 3800 Reservoir Rd., NW, Washington, D. C. 20007. 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E. 1 July 1967Volume 67, Issue 1Page: 60-67KeywordsAdipose tissueArthritisHealth insuranceHospital medicineMetabolic disordersObesityRehabilitation medicineResearch fundingResearch grantsStarvation ePublished: 1 December 2008 Issue Published: 1 July 1967 PDF downloadLoading ...