Mediastinal Germ Cell Tumor Associated with the Hemophagocytic Syndrome
Authors: Thomas J. Myers
Journal: Annals of Internal Medicine (1988)

Brief Reports15 September 1988Mediastinal Germ Cell Tumor Associated with the Hemophagocytic SyndromeThomas J. Myers, MD, Noubar Kessimian, MD, Stanley Schwartz, MDThomas J. Myers, MDSearch for more papers by this author, Noubar Kessimian, MDSearch for more papers by this author, Stanley Schwartz, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-6-504 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe hemophagocytic syndrome is a reactive disorder of the monocyte-macrophage system characterized clinically by an acute onset, fever, lymphadenopathy, hepatosplenomegaly, and pancytopenia (1). The hemophagocytic syndrome can be differentiated from malignant histiocytosis by a potentially self-limited clinical course and by histologic findings of generalized monocyte-macrophage proliferation with prominent hemophagocytosis but without features of malignancy (1, 2). The hemophagocytic syndrome has been reported in association with infections ( 1 ), non-Hodgkin lymphoma (2), Hodgkin disease (3), chronic lymphocytic leukemia (4), acute lymphocytic (5) and nonlymphocytic (6) leukemias, and gastric carcinoma (7).Extragonadal germ cell tumors are found in 10% to 15%...References1. RisdallMcKennaNesbit RRM. Virus-associated hemophagocytic syndrome: a benign histiocytic proliferation distinct from malignant histiocytosis. Cancer. 1979;44:993-1002. CrossrefMedlineGoogle Scholar2. JaffeCostaFauciCossmanTsokos EJAJM. Malignant lymphoma and erythrophagocytosis simulating malignant histiocytosis. Am J Med. 1983;75:741-9. CrossrefMedlineGoogle Scholar3. KormanSmithLandawDavey LJSF. Hodgkin's disease: intramedullary phagocytosis with pancytopenia. Ann Intern Med. 1979;91:60-1. LinkGoogle Scholar4. ManoharanCatovskyLampertAl-MashadhaniGordon-SmithGalton ADIED. Histiocytic medullary reticulosis complicating chronic lymphocytic leukaemia: malignant or reactive? Scand J Haematol. 1981;26:5-13. CrossrefMedlineGoogle Scholar5. SkarinKarbReynolds AKE. Acute leukemia terminating as histiocytic medullary reticulosis. Arch Pathol. 1972;93:256-60. MedlineGoogle Scholar6. TheodorakisZamkoffDaveyGinsbergCassGottlieb MKFSDA. Acute nonlymphocytic leukemia complicated by severe cytophagocytosis of formed blood elements by nonmalignant histiocytes: cause of significant clinical morbidity. Meds Pediatr Oncol. 1983;11:20-6. CrossrefMedlineGoogle Scholar7. SchumacherStass HS. Histiocytic medullary reticulosis [Letter]. Lancet. 1979;1:158-9. CrossrefMedlineGoogle Scholar8. GarnickGriffin MJ. Idiopathic thrombocytopenia in association with extragonadal germ cell cancer. Ann Intern Med. 1983;98:926-7. LinkGoogle Scholar9. DeMentEgglestonSpivak SJJ. Association between mediastinal germ cell tumors and hematologic malignancies: report of two cases and review of the literature. Am J Surg Pathol. 1985;9:23-30. CrossrefMedlineGoogle Scholar10. NicholsHoffmanEinhornWilliamsWheelerGarnick CRLSLM. Hematologic malignancies associated with primary mediastinal germ-cell tumors. Ann Intern Med. 1985;102:603-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Thomas J. Myers, MD; Noubar Kessimian, MD; Stanley Schwartz, MDAffiliations: From Pawtucket Memorial Hospital, Pawtucket; and Brown University, Providence, Rhode Island. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrimary mediastinal germ cell tumorsPrimary mediastinal germ cell tumor and clonally related and unique hematologic neoplasms with i(12p) and TP53 mutation: A report of two casesGerm Cell TumorsSuccessful treatment of a primary mediastinal germ cell tumour complicated by hemophagocytic syndromeHow I treat hemophagocytic lymphohistiocytosisMediastinal endodermal sinus tumor associated with fatal hemophagocytic syndromeFocal haemophagocytosis within an undifferentiated colon carcinoma: a potential for misdiagnosisMalignant Histiocytoses/Disseminated Histiocytic Sarcoma With Hemophagocytic Syndrome in a Patient With Mediastinal Germ Cell TumorPrimary Mediastinal Non-seminomatous Germ Cell Tumor Associated with Hemophagocytic SyndromeFatal hemophagocytic syndrome as initial manifestation of a mediastinal germ cell tumorGerm Cell Neoplasms and Other Malignancies of the MediastinumMediastinal Non-seminomatous Germ Cell Tumours: Their Association with Non-germ Cell MalignanciesHemolytic anemia and cancerHemophagocytic Syndrome in Epstein-Barr Virus-Associated T-Lymphoproliferative Disorders: Disease Spectrum, Pathogenesis, and ManagementA case of histiocytic medullary reticulosis complicated with x-ray-irradiated oral cancerPathology of Extragonadal Yolk Sac TumorsFatal Virus-Associated Hemophagocytic Syndrome in a Young Adult Producing Nontraumatic Splenic RuptureHemophagocytic syndrome associated with aggressive natural killer cell leukemiaExtragonadal and poor risk nonseminomatous germ cell tumors. Survival and prognostic featuresSystemic mast cell disease associated with primary mediastinal germ cell tumorSystemic mast cell disease associated with primary mediastinal germ cell tumorMalignant Hematologic Disorders Arising from Mediastinal Germ Cell Tumors. A Review of Clinical and Biologic FeaturesHematologic Neoplasia Associated with Primary Mediastinal Germ-Cell TumorsHematologic manifestations of malignancy 15 September 1988Volume 109, Issue 6Page: 504-505KeywordsChronic lymphocytic leukemiaFeversGerm cellsHepatosplenomegalyHodgkin lymphomaInfectious diseasesLeukemia ePublished: 1 December 2008 Issue Published: 15 September 1988 PDF downloadLoading ...