tbuckley/cabot-search huggingface dataset:
Sinus Bradycardia Following Ritodrine Withdrawal
Authors: Hadassah Dean
Journal: JAMA (1982)

<h3>To the Editor.—</h3> The β-agonist ritodrine hydrochloride is widely used to delay premature labor. We recently witnessed notable sinus bradycardia after withdrawal of this drug. <h3>Report of a Case.—</h3> A 33-year-old woman was admitted to the gynecologic department on her 33rd week of pregnancy because of premature uterine contractions. Placenta previa was diagnosed. During the next five weeks she was initially treated with 60 mg/day of ritodrine hydrochloride, intramuscularly and later with the same agent, 50 mg/day, orally. An uneventful cesarean section was performed at the 38th gestation week. Twelve days later she was readmitted after a syncopal episode. The only relevant physical finding was a notable sinus bradycardia of 40 beats per minute. The ECG indicated tall T waves and a prolonged Q-T interval (Q-T, 0.7 s). After 1 mg of atropine was administered intravenously, the pulse rate increased to 60 beats per minute but the Q-T interval did
1167-222 Biventricular pacing resynchronizes septal perfusion/wall motion match by a primary increase of myocardial blood flow
Authors: Alessia Gimelli, Marcello Piacenti, Mario Stanislao, Umberto Startari, Assuero Giorgetti, Ennio Pisano, Maria Aurora Morales, Paolo Marzullo
Journal: Journal of the American College of Cardiology (2004)
Cardiovascular Magnetic Resonance Imaging for Diagnosis of Stress Cardiomyopathy
Authors: Saurav Chatterjee, Subhankar Maitra
Journal: JAMA (2011)

To the Editor: The study by Dr Eitel and colleagues1 attempted to identify cardiac magnetic resonance (CMR) imaging criteria for accurate diagnosis of stress cardiomyopathy (SC). The data on this phenomena thus far have been sparse and heterogeneous. However, a few points require clarification.
Changes to death certificates waste golden opportunity
Authors: Clare Dyer
Journal: BMJ (2006)

The UK government's draft bill to reform the coroners' system and the way deaths are certified was strongly criticised this week by the House of Commons' Constitutional Affairs Committee, which said it would do nothing to remedy the “critical defects in the death certification system.”

The MPs said that ministers risked “wasting a golden opportunity” to reform the system of death certification and investigation in England and Wales, which dates partly from Victorian times and partly from much earlier.

They cited evidence to the committee by Dame Janet Smith, the high …
Autoimmunity and Rheumatoid Arthritis
Authors: R. A. Thompson
Journal: BMJ (1965)

in your issue of 10 July (p.59), which would be misleading to any reader who wishes to go back to the sources of reference.It was stated that the detection of precipitating anti- bodies against Thermopolyspora polyspora was reported by Pepys and colleagues in Thorax 1962.1 Whilst this report dealt with the precipitating antibodies in farmer's lung against extracts of mouldy hay, the discovery that thermophilic actinomycetes such as T. polyspora and Thermoactinomyces (Micronionospora) vulgaris, and particularly T. polyspora, are an important source of antigens in farmer's lung was reported by Pepys et al. in the Lancet in 1963.2The antigens in specimens of mouldy hay responsible for farmer's lung and present in extracts of T. polyspora have been termed " farmer's lung hay " (FLH) antigens.A clinical evaluation of the precipitin (FLH) test in farmer's lung has been reported by Pepys and Jenkins.'This showed that an insidious onset of the attacks is not rare, as stated in your editorial.In 205 patients with farmer's lung, 49% had an insidious onset, 9 , , started with attacks of insidious onset and subsequently had the typical attacks coming on after some hours, 32% had typical attacks from the beginning, and in 10°,,, after a period of attacks with insidious or typical onset, attacks later came on more rapidly with a more marked bronchial com- ponent to the reaction.The clinical and serological findings in the patients in the different groups were comparable.Staines and Forman4 have previously reported that an insidious or typical onset occurred equally frequently.It is desirable that the different modes of presentation, other than those of the classical description, should be recog- nized.-Iam, etc.,
Does AIDS 'cure' rheumatoid arthritis?
Authors: J W Bijlsma, R W Derksen, O Huber-Bruning, J C Borleffs
Journal: Annals of the Rheumatic Diseases (1988)

Behqet's disease and pregnancy SIR, At the 3rd International Conference on Behcet's Disease it was proposed that hormonal factors may influence the pathogenesis of this disease.'A variable influence of pregnancy has been reported.Madkour and Kudwah reported exacerbation of mucocutaneous and arthritic manifestations in four women,2 and Plouvier and Devulder,3 Ferraro et al,4 and Suchenwirths have reported remission during pregnancies.We studied 21 pregnancies in eight women with Behqet's disease, who each had at least three major criteria for diagnosis.The disease was classified as mucocutaneous in five, arthritic in one, and of the ocular type in two.6 Clinical manifestations were oral ulceration (eight patients), genital ulceration (eight), erythema nodosum (six), positive pathergy test (five), and uveitis (two).The histocompati- bility antigen HLA-B5 was present in five of six patients tested.Behqet's disease did not influence any pregnancy, there being no abortions, prematurity, or perinatal deaths.
Association between transfusion of whole blood and recurrence of cancer.
Authors: N Blumberg, J M Heal, P Murphy, M M Agarwal, C Chuang
Journal: BMJ (1986)

Transfusion affects the immune response to renal transplantation and may be associated with recurrence of various human neoplasms. Data from patients with colonic, rectal, cervical, and prostate tumours showed an association between transfusion of any amount of whole blood or larger amounts of red blood cells at the time of surgery and later recurrence of cancer. Recipients of one unit of whole blood had a significantly higher incidence of recurrence (45%) than recipients of a single unit of red cells (12%) (p = 0.03). Recipients of two units of whole blood also had a higher rate of recurrence (52%) than those receiving two units of red cells (23%) (p = 0.03). Recipients of any amount of whole blood had similar recurrence rates (38-52%). Recipients of four or more units of red blood cells had a higher rate of recurrence (55%) than those receiving three or fewer units of red blood cells (20%) (p = 0.005). Mortality due to cancer in patients receiving three or fewer units of red blood cells (2%) was similar to that in patients who did not have transfusions (7%) and significantly lower than that observed in patients receiving three or fewer units of whole blood (20%) (p = 0.003). A proportional hazards risk analysis showed that transfusion of any whole blood or more than three units of red blood cells was significantly associated with earlier recurrence and death due to cancer. These data support an association between transfusion and recurrence of cancer. They also suggest that some factor present in greater amounts in whole blood, such as plasma, may contribute to the increased risk of recurrence in patients who have undergone transfusion. Until the questions raised by retrospective studies of cancer recurrence and transfusion can be answered by prospective interventional trials with washed red blood cells, red blood cells should be transfused to patients with cancer in preference to whole blood when clinically feasible.
Genetic control of the eighth component of complement.
Authors: D Raum, M A Spence, D Balavitch, S Tideman, A D Merritt, R T Taggart, B H Petersen, N K Day, C A Alper
Journal: Journal of Clinical Investigation (1979)

Using isoelectric focusing in polyacrylamide gel and a hemolytic assay for development of patterns, extensive, structural polymorphism in human C8 has been delineated. Two alleles, C8A and C8B, have been identified in orientals, with gene frequencies of 0.655 and 0.345. In blacks, what appears to be a third common allele was found, so that frequencies were 0.692, 0.259, and 0.049 for C8A, C8B, and C8A1. In whites, C8A1 was rare with a frequency of 0.003, and frequencies for C8A and C8B were 0.649 and 0.349. Inheritance was autosomal codominant in family studies and the distribution of types in random unrelated populations fit the Hardy-Weinberg equilibrium in all groups. C8 allotypes have been determined for two previously studied families, each with a homozygous C8-deficient propositus. This study suggests that C8 deficiency is a silent or null allele of the C8 structural locus, and that half normal levels of C8 cannot be used as a single criterion for the establishment of heterozygous C8 deficiency. C8 allotypes, as well as 18 other autosomal markers, were also determined for 24 families. The C8 structural locus is not closely linked to these markers, including the human histocompatibility loci complex.
The quality of life after cardiac surgery.
Authors: J K Ross, J L Monro, A E Diwell, J M Mackean, J Marsh, D J Barker
Journal: BMJ (1981)

A follow-up study to assess the quality of life after cardiac surgery was begun in 1973. The results, for a total of 383 patients followed up for a maximum of 44 months after surgery, showed an overall improvement in all aspects of life for most patients.
Programming of Insulin Delivery with Meals During Subcutaneous Insulin Infusion
Authors: Donald J Chisholm, Edward W Kraegen, Guido S Zelenka
Journal: Diabetes Care (1981)

The serum insulin elevation after subcutaneous (s.c.) infusion of 10 U of neutral regular insulin given over 5 or 30 min has been examined in normal subjects to find a delivery profile that would simulate the normal serum insulin response to a meal. Endogenous insulin release, assessed by measurement of C-peptide, was suppressed by an i.v. infusion of 1 U/h neutral regular insulin, beginning 60 min before the s.c. administration and continuing throughout the study. The increment in serum insulin levels after the 5-min s.c. infusion reached a peak of 62 ± 9.5 mU/L at 45 min, and the rate of elevation of insulin levels closely approximated the normal insulin response to a 50-g, 500 kcal mixed meal. The increment in serum insulin levels with the 30-min s.c. infusion reached a peak of 41 ± 1.4 mU/L at 75 min. The incremental insulin response up to 180 min (area under the curve) after the 5-min s.c. infusion was 30% greater than the response to the 30-min infusion. On the basis of these studies, we conclude that insulin delivery for meals during s.c. insulin infusion need not be initiated before the meal, but should be given over a period of approximately 5 min or less. Further study is required to delineate the effects of concentration, local degradation, and rate of delivery on entry of s.c. insulin to the vascular system.
Increased incidence of glomerulonephritis following spleno-renal shunt surgery in non-cirrhotic portal fibrosis
Authors: Suresh C. Dash, Uday N. Bhuyan, Amit K. Dinda, Sanjiv Saxena, Sanjay K. Agarwal, Suresh C. Tiwari, Samiran Nundy
Journal: Kidney International (1997)
Phlebothrombosis and Prevention of Pulmonary Embolism
Authors: H. Bailey
Journal: BMJ (1948)

quoted pight cases, four of which were his own.One of these four proved at necropsy to have had an aneurysm of the right posterior communicating artery which had burst; two others were probably vascular in origin, since in one case there was amnesia and in the other paraesthesiae; and the last of the four-a healthy young woman of 27-was a case of right permanent hemianopia as a result of idiopathic migraine, with sparing of the macula by less than 10 degrees and otherwise a clean-cut vertical edge above and below.She was re-examined six weeks later, but there was no alteration.The ages of these four patients varied from 15 to 67 and all had had proved intracranial vascular catastrophes.Peter (1938), quoting Charcot and others in their descrip- tion of cases of persistent quadrantic and hemianopic scotomata following migraine, remarks that other cases have appeared in the literature from time to time; while Adie (1930), drawing attention to permanent hemianopia in migraine, migrainous epilepsy, and spontaneous subarach- noid haemorrhage and their probable interrelationship, describes seven cases in which there was probably a sub- arachnoid haemorrhage.Dixon (1947), in drawing attention to the frequency of strokes in young adults, mentions four cases of field defect in young people associated with a probable intracranial haemorrhage,Comment.-In this brief review of the literature 63 cases are mentioned, of which 14 seem to be of true idiopathic migrainous origin, and 49 have been associated with intra- cranial haemorrhage-a ratio of 2 : 7. It seems likely, therefore, that many more cases of migraine than appear in the literature would show permanent field defects, that sooner or later a number of these would show other signs of intracranial haemorrhage, embolism, or thrombosis, and that the relationship between migraine, epilepsy, and subarachnoid haemorrhage is closer than has 'been recog- nized.Attention is also drawn to its greater frequency in women. SumimaryA case of permanent quadrantanopia subsequent to 20 years of repeated attacks of idiopathic migraine is described.The probable site of the lesion-at first functional, later organic-is discussed.A review of the literature revealed only 13 other cases.
Mathematical models for predicting indoor air quality from smoking activity.
Authors: W R Ott
Journal: Environmental Health Perspectives (1999)

Much progress has been made over four decades in developing, testing, and evaluating the performance of mathematical models for predicting pollutant concentrations from smoking in indoor settings. Although largely overlooked by the regulatory community, these models provide regulators and risk assessors with practical tools for quantitatively estimating the exposure level that people receive indoors for a given level of smoking activity. This article reviews the development of the mass balance model and its application to predicting indoor pollutant concentrations from cigarette smoke and derives the time-averaged version of the model from the basic laws of conservation of mass. A simple table is provided of computed respirable particulate concentrations for any indoor location for which the active smoking count, volume, and concentration decay rate (deposition rate combined with air exchange rate) are known. Using the indoor ventilatory air exchange rate causes slightly higher indoor concentrations and therefore errs on the side of protecting health, since it excludes particle deposition effects, whereas using the observed particle decay rate gives a more accurate prediction of indoor concentrations. This table permits easy comparisons of indoor concentrations with air quality guidelines and indoor standards for different combinations of active smoking counts and air exchange rates. The published literature on mathematical models of environmental tobacco smoke also is reviewed and indicates that these models generally give good agreement between predicted concentrations and actual indoor measurements.
POISONING FROM DRINKING RADIUM WATER
Authors: ALEXANDER O. GETTLER
Journal: JAMA (1933)

Radioactive salts taken internally in the smallest traces are detrimental to health and fatal to life. This has been definitely proved by the work of Martland and his co-workers,<sup>1</sup>St. George, Gettler and Muller,<sup>2</sup>Hoffman,<sup>3</sup>Castle and Drinker,<sup>4</sup>Flinn<sup>5</sup>and the U. S. Department of Labor,<sup>6</sup>especially in connection with the series of radium watch dial workers in New Jersey. The case to be described in this paper is interesting because it is the first one on record to be diagnosed correctly as radium poisoning, caused by drinking radium water, and in which the autopsy and analysis of the tissues corroborated the diagnosis. <h3>History.</h3> —E. M. B., a man, aged 52, weighing about 110 pounds (50 Kg.), markedly emaciated and anemic, was admitted to the hospital<sup>7</sup>and treated for necrosis of the jaw. He had been drinking a water (said to be "Radithor")
Systemic lupus erythematosus and sickle-cell anaemia.
Authors: W A Wilson, G D Nicholson, G R Hughes, S Amin, G Alleyne, G R Serjeant
Journal: BMJ (1976)

Comparison of mean times ( SD) taken to reach various labour indices Fixed dose Incremental dose Induction-IC (mnu) .. 27-5 ±14-06 10-95 ± 10-65 (P <0-05) IC-AC(h) .. .. 2-50±1-39 0 96±1-16 (P <0 005) IC-5 cm (h) .. .. 3-76 ±3-45 2-80±1 43 IDI (h).10-21 ±6-27 5 25 ±298 (0O5>P>0-01) IC = Initial contractions (recorded tocographically).AC = Adequate contractions (painful). 5cm= End point of trial.IDI = Induction-to-delivery interval.
The High-Affinity Receptor for Immunoglobulin E
Authors: Stephen C. Dreskin
Journal: JAMA (1988)

MAST cells and basophils have a plasma membrane receptor that binds immunoglobulin E (IgE) with high affinity.<sup>1</sup>When the bound IgE reacts with antigen, there is an explosive discharge of preformed mediators of inflammation from storage granules, and newly synthesized potent lipids are likewise released. These substances account for many of the symptoms of allergic diseases.<sup>2</sup>Approaches to the therapy of immediate hypersensitivity reactions can be broadly categorized into four principal strategies: (1) suppression of IgE biosynthesis, (2) generation of "blocking" antibodies, (3) prevention of IgE-mediated stimulation of mast cells, and (4) "neutralization" of the effects of the released mediators. We will consider herein the third of these strategies and focus in particular on preventing activation of the cells by interfering with the binding of IgE to the receptor or by aborting the early events that follow triggering of the receptor. It is important to note that a
Efficacy of Vemurafenib in Hairy-Cell Leukemia
Authors: Jesvin Samuel, Salvador Macip, Martin J S Dyer
Journal: New England Journal of Medicine (2014)

The authors report a case of purine analogue–refractory hairy-cell leukemia with biallelic BRAF V600E mutations and a high leukemic burden that was treated successfully with vemurafenib, a BRAF inhibitor.
Comparison of adenosine and dipyridamole in detecting coronary artery disease using Tc-99m sestamibi single-photon emission computed tomography imaging: A randomized, prospective clinical study
Authors: Tinq Li, Cynthia Taub, Alan Ahlberg, Rory Hachamovitch, Charles Primiano, Mohammed Awaad, Rene Fleming, Carol McGill, William E. Boden, Gary V. Heller
Journal: Journal of the American College of Cardiology (2003)
Mutations in the rod domain of keratin 2e in patients with ichthyosis bullosa of Siemens
Authors: Joseph A. Rothnagel, Heiko Traupe, Sonja Wojcik, Marcel Huber, Daniel Hohl, Mark R. Pittelkow, Hidehisa Saeki, Yasumasa Ishibashi, Dennis R. Roop
Journal: Nature Genetics (1994)
Trends in hospital admissions for childhood asthma in Oslo, Norway, 1980-95
Authors: G. Jónasson, K. C. Lødrup Carlsen, J. Leegaard, K.‐H. Carlsen, P. Mowinckel, K. S. Halvorsen
Journal: Allergy (2000)

Background: Prevalence of asthma and quality of asthma care both influence hospital admission rates for childhood asthma. Therefore, we aimed to assess possible changes in hospital admission rate for acute asthma in Oslo, Norway, from 1980 to 1995, as well as evaluate the possible effect of changes in asthma treatment upon hospitalization for acute asthma in this period. Methods: All pediatric patient records from the two municipal hospitals in Oslo from 1980 through 1995 with the discharge diagnosis (ICD‐9) acute asthma, acute bronchitis/bronchiolitis, pneumonia, and/or atelectasis were thoroughly reviewed. Results: Of the 3538 children admitted for acute asthma, 66% were boys and 75% were younger than 4 years, and the admittance rate increased significantly among children aged 0–3 years. First admissions increased throughout the study, whereas readmissions, as well as the mean duration of hospital stay, decreased significantly. Prophylactic treatment with inhaled steroids prior to admission increased over 1980–89, but stabilized thereafter. The use of a short course of systemic steroids during admission increased markedly from 1991. Conclusions: The findings of increasing first admission rate as well as overall admission rate for acute asthma in children under 4 years of age, but decreasing readmissions as well as number of treatment days in hospital, probably reflect changes in the management of the disease, as well as an increasing prevalence of childhood asthma.
Regulated Expression of the Ets-1 Transcription Factor in Vascular Smooth Muscle Cells In Vivo and In Vitro
Authors: Anna Hultgårdh-Nilsson, Bojan Cercek, Jian-Wei Wang, Shinji Naito, Cecilia Lövdahl, Behrooz Sharifi, James S. Forrester, James A. Fagin
Journal: Circulation Research (1996)

Ets-1 regulates the transcription of several genes encoding extracellular matrix proteins (ie, osteopontin and tenascin) as well as enzymes involved in degradation and remodeling of the extracellular matrix (ie, stromelysin and urokinase plasminogen activator). In the present study, we investigated the regulation of c-ets-1 in cultured rat vascular smooth muscle cells as well as in the arterial wall after balloon injury in vivo. Serum-starved smooth muscle cells exposed to serum for various time points express a major c-ets-1 mRNA transcript of 5.3 kb and minor bands of 4.0 and 2.5 kb with a peak at 2 hours after stimulation. These effects were concentration dependent. Western blotting revealed an increase in 55- and 40-kD immunoreactive ets-1 proteins in cells treated with serum for 2 hours, and binding to an oligonucleotide containing the ets-1 consensus cis-acting motif was demonstrated by electrophoretic mobility shift assay. Ets-1 mRNA abundance was induced with a peak at 2 hours after stimulation with platelet-derived growth factor-BB and with angiotensin II. There was a distinct increase of ets-1 immunoreactivity in the inner layer of the media 2 hours after balloon catheter injury of rat arteries, which declined after 6 hours and returned to the basal level 1 day after vessel wall damage. Arterial c-ets-1 mRNA content was induced with an identical time course. These findings suggest that c-ets-1 may be of importance in the mitogenic signaling pathway of smooth muscle cells grown in culture. In addition, ets-1 may play a role in the activation of smooth muscle cells in vivo after mechanical injury of the vessel wall. Because the ets-1 transcription factor activates the gene expression of a number of mRNA species involved in matrix deposition and degradation, these data are compatible with a role for ets-1 in vascular remodeling and/or cell migration.
The performance of silk scaffolds in a rat model of augmentation cystoplasty
Authors: Abhishek Seth, Yeun Goo Chung, Eun Seok Gil, Duong Tu, Debra Franck, Dolores Di Vizio, Rosalyn M. Adam, David L. Kaplan, Carlos R. Estrada, Joshua R. Mauney
Journal: Biomaterials (2013)