tbuckley/cabot-search huggingface dataset:
Massive fibrous epulis—a case report of a 10-year-old lesion
Authors: Gabriel M Fonseca, Ricardo M Fonseca, Mario Cantín
Journal: International Journal of Oral Science (2013)

The fibrous epulis, a common tumor-like lesion of the gingiva, appears in the interdental papilla as a result of local irritation. Lesions are asymptomatic and have a variable growth rate. A 75-year-old woman was referred for the evaluation of a large painless gingival mass. It had started 10 years back and has been increasing in size the last year. No bone involvement was noted. The tumor was totally removed by excision with surgical scalpel under local anesthesia without teeth extraction. The microscopic findings were suggestive of a fibrous epulis. Differential diagnosis, clinical considerations and factors to prevent recurrence are discussed.
Frequency of Circulating Tregs with Demethylated <i>FOXP3</i> Intron 1 in Melanoma Patients Receiving Tumor Vaccines and Potentially Treg-Depleting Agents
Authors: I. Jolanda M. de Vries, Chiara Castelli, Caroline Huygens, Joannes F.M. Jacobs, Julie Stockis, Beatrice Schuler-Thurner, Gosse J. Adema, Cornelis J.A. Punt, Licia Rivoltini, Gerold Schuler, Pierre G. Coulie, Sophie Lucas
Journal: Clinical Cancer Research (2010)

Regulatory T cells (Tregs) are thought to inhibit antitumor immune responses, and their depletion could therefore have a synergistic effect with therapeutic cancer vaccines. We investigated the impact of three medications on blood Treg frequency in vaccinated cancer patients.To date, the most specific marker for human Tregs is demethylation in the DNA that encodes the transcription factor FOXP3. Thus, we used a FOXP3 methylation-specific quantitative PCR assay (MS-qPCR) to measure Treg frequencies in the peripheral blood mononuclear cells (PBMCs) of melanoma patients. The patients participated in three clinical trials that combined tumor vaccines with potential Treg-depleting agents: low-dose cyclophosphamide, anti-CD25 monoclonal antibody daclizumab, and the IL-2/diphtheria toxin fusion protein denileukin diftitox.In the nine control patients, blood Treg frequencies varied over time; there was a 46% reduction in one patient. In treated patients, a more than 2-fold decrease in Tregs was observed in one out of 11 patients receiving cyclophosphamide and in four out of 13 receiving daclizumab, but there was no such Treg decrease in any of the six patients who received denileukin diftitox. As a positive control, a more than 2-fold increase in blood Tregs was detected in four out of nine patients who were treated with interleukin-2.We used a MS-qPCR method that detects Tregs but not other activated T lymphocytes; however, none of the Treg-depleting strategies that we tested led, in the majority of patients, to a conservative 50% reduction in blood Tregs.
Reviews and Notes: Psychiatry: Psychiatric Dictionary
Authors: Edward J. Huth
Journal: Annals of Internal Medicine (1996)

Literature of Medicine1 December 1996Reviews and Notes: Psychiatry: Psychiatric DictionaryEdward J. Huth, MD, Editor EmeritusEdward J. Huth, MD, Editor EmeritusUniversity of Pennsylvania, Philadelphia, PA 19104.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-11-199612010-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail 7th edition. RJ Campbell. New York: Oxford Univ Pr; 1996. $59.95. ISBN 0-19-510259-2. Order phone 800-451-7556.This is not a dictionary in the usual sense. Most dictionaries simply define words and phrases at their entry points. Some also explain etymologic origins and indicate pronunciation. Campbell's dictionary can more accurately be described as a one-volume terminologic encyclopedia. Some definitions hold to the brevity expected in a dictionary, but others are, in effect, short articles that include much more than simple definition. For example, the entry for “instinct, death” runs to a column and a half; that for “ion channel” occupies two ... Author, Article, and Disclosure InformationAffiliations: University of Pennsylvania, Philadelphia, PA 19104. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1996Volume 125, Issue 11Page: 944KeywordsAlzheimer diseaseInstinctIon channels ePublished: 15 August 2000 Issue Published: 1 December 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Traffic contributes to rise in asthma, says report
Authors: L Dillner
Journal: BMJ (1994)

Air pollution from traffic is contributing to the steady rise in asthma, says a report published last week by the Parliamentary Office of Science and Technology. The National Asthma Campaign estimates that one in 10 children has asthma, and data from the Department of Health suggest that hospital admissions for the condition increased from 4000 in 1980 to 10 000 in 1990.

* One in 10 children has asthma. Does air pollution have anything to do with it?

(Fig Omitted)

The report says: “While the evidence is not conclusive, the long-term trend in …
THE ANATOMY AND RADICAL CURE OF INGUINAL HERNIA.
Authors: DANIEL N. EISENDRATH
Journal: JAMA (1904)

An accurate conception of the anatomic relations of the inguinal region in its normal condition and again when a hernia is present is essential to the surgeon. The inguinal canal as we find it during the course of an operation differs somewhat from that as we know it from our dissections. Normally there is no inguinal canal after the test is has descended into the scrotum. Even prior to the migration of the testis from its position just below the kidney to the inguinal canal, the latter contains a pouch or diverticulum of peritoneum which is the vaginal process. If the testis remains in the inguinal canal or even in ihe upper part of the scrotum (just outside the external abdominal ring) this pouch remains open and a hernia results in the majority (50 per cent.) of cases of undeseended testis.
Survey of treatment recommendations for anaplastic oligodendroglioma
Authors: Lauren E. Abrey, David N. Louis, Nina Paleologos, Andrew B. Lassman, Jeffrey J. Raizer, Warren Mason, Jonathan Finlay, David R. MacDonald, Lisa M. DeAngelis, J. Gregory Cairncross
Journal: Neuro-Oncology (2007)

Anaplastic oligodendroglioma is a malignant brain tumor uniquely sensitive to treatment with both chemotherapy and radiotherapy. There are few prospective clinical trials for newly diagnosed patients and multiple approaches to the treatment of these patients. This study explored the recommended treatment offered by experts in neuro-oncology. A Web-based survey was developed and distributed to 800 members of the Society of Neuro-Oncology (SNO) who had an e-mail address listed with SNO. Questions addressed use of molecular genetic information and treatment recommendations. A total of 99 clinical SNO members (20%) responded. The majority reported practicing at an academic center in the United States. Two-thirds of respondents see more than five patients with newly diagnosed anaplastic oligodendroglioma annually. Molecular genetic testing was requested for more than 75% of patients, and the results significantly influenced treatment recommendations (p = 0.000003). Regardless of molecular genetic status, the most commonly recommended treatment was the use of concurrent temozolomide and radiotherapy followed by adjuvant temozolomide (18%-34%). The current survey demonstrates that although neuro-oncologists have embraced the use of molecular genetic studies in newly diagnosed anaplastic oligodendroglioma, treatment recommendations vary widely and are often independent of the molecular data.
Plasma levels and urinary excretion of gold during routine treatment of rheumatoid arthritis.
Authors: F E Krusius, A Markkanen, P Peltola
Journal: Annals of the Rheumatic Diseases (1970)

In the treatment of rheumatoid arthritis (RA) by gold, it has been customary to administer the gold by weekly injections of equal amounts, e.g.50 mg.sodium aurothiomalate weekly (Freyberg, 1957).According to reports in the literature the percentage of satisfactory therapeutic results may vary from 23 to 85 per cent., and the percentage of toxic reactions from 5 to 62 per cent.(Fraser, 1945; Freyberg, 1966).Gold levels in blood and urine may change from one day to another after gold injections, but the differences between individual patients receiving the same treatment and their relationships to the therapeutic effect have received little attention.Freyberg, Block, and Levey (1941) assayed the gold content of plasma and urine after injections of different gold preparations and during toxic reactions, but found no correlation with the plasma gold level.The same conclusion was drawn by Lawrence (1961) in studies with radioactive gold.Smith, Peak, Kron, Hermann, Del Toro, and Goldman (1958), however, found that a poor therapeutic effect was related to a high urinary excretion of gold and toxic reactions to a low ex- cretion; they performed no gold assays of the blood.In the present study, gold levels in blood and urine were determined in 25 patients with rheumatoid arthritis who were receiving gold therapy, and correlated with therapeutic effect and toxic reaction.
Early apoptosis plays an important role in the healing mechanism of cutaneous basal cell carcinomas after photodynamic therapy
Authors: F. Prignano, B. Bianchi, L. Domenici, R. Rossi, P. Romagnoli, N. Pimpinelli, P. Cappugi, B. Giannotti
Journal: British Journal of Dermatology (2003)

Sir, Topical photodynamic therapy (PDT) with δ‐5‐aminolaevulinic acid (5‐ALA) is increasingly used in precancerous skin lesions (actinic keratoses) and nonmelanoma skin cancer [superficial basal cell carcinoma (BCC); Bowen's disease].1 The mechanism of PDT depends on the activation of a photosensitizing compound by visible light of an appropriate wavelength that correlates with the absorption spectrum of the photosensitizing compound in the presence of molecular oxygen. The exogenous prodrug 5‐ALA is converted intracellularly to the endogenous photosensitizer protoporphyrin IX, with preferential accumulation in neoplastic/dysplastic tissue and consequent absorption of photons.2 This latter results in a cascade of events, in which apoptosis has been suggested to play an important role.3 In the present study, we have investigated the possible role of apoptosis by the sequential analysis of lesional skin after 5‐ALA‐PDT (5‐ALA in a 20% oil‐in‐water emulsion under occlusion, and visible light by the lamp Fotoec 3 H250, Loto, Florence, Italy: wavelength within the 630‐nm range) in eight patients with superficial BCC after informed consent. The neoplastic skin samples were collected 15 min and 4, 24, 48 and 72 h after the irradiation in order to investigate the possible modifications at the cellular and subcellular level (by electron microscopy), the expression of apoptotic markers [alkaline phosphatase–antialkaline phosphatase (APAAP) and terminal deoxynucleotidyl transferase‐mediated deoxyuridine triphosphate nick end labelling (TUNEL) methods], and the immunophenotypic profile of the inflammatory cell infiltrate (APAAP).
Dietary Supplements for Arthritis?
Authors: Joan Stephenson
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A low-pitched scream.
Authors: J O Drife
Journal: BMJ (1979)

Her Majesty's Stationery Office certainly does things well. The Report of the Royal Commission on the National Health Service has on its title page a huge regal coat of arms, on page ii a statement that the Commission spent ?918 000, and on page iii a Royal Warrant, couched in swashbuckling Elizabethan phraseology and signed (By Her Majesty's Command) by Roy Jenkins. By the time he reaches the Introduction, the reader feels that any critic of the report risks being marched at halberd point into the Tower. At about 200 000 words (working out at ?4-59p per word) the report is briefer than the Old Testament (which has 600 000 words) and easier to read. The English is beautifully clear, the tone seems balanced and objective, and there are warming traces of donnish humour. The lucid style reassures us that the authors have indeed been chosen, as we were promised in 1976 that they would be, for their experience, expertise and wisdom. They were presumably also chosen for their stamina, since all but two survived three years' service, 2460 written submissions, and 2800 informal chats. Where, one wonders, were such exemplary people found ?
Long-term Acyclovir Suppression of Frequently Recurring Genital Herpes Simplex Virus Infection
Authors: Gregory J. Mertz
Journal: JAMA (1988)

Normal adults with six or more episodes of genital herpes in the previous year were enrolled in a one-year, multicenter, double-blind trial comparing placebo with 400 mg of acyclovir administered orally twice daily. Patients with episodes during the study were offered 200 mg of acyclovir administered orally five times daily for five days; this allowed comparison of suppressive and episodic treatment. After one year, 227 (44%) of 519 patients receiving suppressive treatment and seven (2%) of 431 receiving placebo (episodic) treatment remained free of recurrences, and the mean numbers of recurrences per year were 1.8 and 11.4, respectively. Among 67 patients who had received suppressive therapy for one year, the mean duration of lesions in the first episode following the discontinuation of treatment was 9.3 days compared with 7.3 days among 45 patients who had received episodic therapy for one year. Treatment was well tolerated, and no changes were noted in the in vitro susceptibility to acyclovir of herpes simplex virus cultured during or after the one-year trial. Continuous or episodic oral acyclovir therapy for one year remained safe and effective.
The Dicrotic Arterial Pulse
Authors: GORDON A. EWY, JORGE C. RIOS, FRANK I. MARCUS
Journal: Circulation (1969)

The study consisted of observations on nine male patients with palpable dicrotic as evidenced by cardiomegaly and the presence of prominent atrial and ventricular diastolic gallop sounds. Most of these patients were diagnosed as having primary myocardial disease. The indirect carotid pulse was characterized by a single systolic wave, a low dicrotic notch, and a large dicrotic wave. The direct brachial arterial pressure pulse had a similar configuration with a shortened ejection time index. The hemodynamic data on these patients was characterized by low cardiac output, low stroke volume, elevated pulmonary arterial wedge pressures, and high total systemic resistance. From these observations we conclude that the presence of a marked dicrotic pulse in afebrile patients at rest may indicate severe functional impairment of the myocardium.
Enforcement of School Immunization Law in Alaska
Authors: John P. Middaugh
Journal: JAMA (1978)

Investigation of measles outbreaks during the fall of 1976 led to the discovery that Alkaska's school immunization law was not being enforced. In an effort to control a large outbreak of measles in Fairbanks, children were required to show proof of measles vaccination or be excluded from school. Of the Fairbanks schoolchildren, 25% were vaccinated against measles; 1,251 (11%) of 11,727 unvaccinated schoolchildren were excluded in January, and no further cases of measles occurred. Subsequently, the school law was enforced statewide, and on March 1, 1977, all children not immunized against diphtheria, tetanus, pertussis, polio, measles, and rubella were excluded from school (7,418 [8.3%] of 89,108). One month later, fewer than 51 children still did not meet immunization requirements. More than 35,000 children were vaccinated in the immunization campaign; no adverse side effects to any vaccine were reported.
A Handbook for the Study of Suicide
Authors: Martin R. Lipp
Journal: JAMA (1975)

Like most collections of essays written by various authors, the material in this volume is uneven in quality, format, and clinical relevance. Some articles have been previously published, others have not. This handbook was intended to provide "a suitable background source" to the first formal Fellowship Program in Suicidology, following its inauguration at Johns Hopkins University in 1967. The historical approach is emphasized, with the intent of establishing "the circumstances under which social groups accept or reject human selfdestruction." Authors represent the disciplines of history, literature, anthropology, sociology, epidemiology, psychiatry, biology, and philosophy. Clearly, with so many contributors in such a slim volume, the coverage is necessarily more remarkable for its breadth than for its depth. Nonetheless, the approach is generally scholarly, and extensive bibliographies guide the reader to further resources.
Transatlantic debate on addiction.
Authors: P H Wilcox
Journal: BMJ (1971)

1971coronary care.This means that individuals trained in coronary care and conver-ant with the use and limitations of antiarrhythmic agents should reach the patient as soon as possible after the onset of symptoms, relieve pain, stabilize the rhythm, and monitor the patient continuously during his transport to the coronary care unit.It also means that the patient must be admitted directly to the hospital coronary care unit, since delay and disturbance in the casualty department may aggravate the early dysrhythmias and lead to extension of the area of infarction.2-Weare, etc.,
Nurse-like cells from bone marrow and synovium of patients with rheumatoid arthritis promote survival and enhance function of human B cells.
Authors: Y Shimaoka, J F Attrep, T Hirano, K Ishihara, R Suzuki, T Toyosaki, T Ochi, P E Lipsky
Journal: Journal of Clinical Investigation (1998)

Thymic nurse cells are known to interact with T cells and play a role in their functional maturation. However, the role of nurse cells in B cell maturation and differentiation is less well established, especially at extralymphoid sites. To address this issue, nurse-like cell clones from bone marrow and synovial tissue of patients with RA (RA-NLC) were established and characterized. RA-NLC constitutively expressed CD29, CD49c, CD54 (ICAM-1), CD106 (VCAM-1), CD157 (BST-1), and class I MHC molecules, and secreted IL-6, IL-7, IL-8, granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF). Bone marrow-derived and synovial RA-NLC differed in that the former secreted IL-7 and expressed a greater density of CD157 constitutively and after stimulation with IFNgamma, whereas the latter secreted G-CSF and more IL-6. Stimulation of both bone marrow and synovial RA-NLC induced expression of CD40 and class II MHC, but not CD154 (CD40L) or CD35. RA-NLC rescued peripheral B cells from spontaneous apoptosis and promoted survival of B cells for > 4 wk. B cell survival was blocked by antibodies to CD106 or CD157. RA-NLC also increased Ig production from B cells. After long-term culture (4-6 wk) with RA-NLC, but not alone or with fibroblasts, outgrowth of B cells was observed. All B cell lines derived from these cultures had been transformed by EBV, although the RA-NLC themselves were not infected with EBV. Precursor frequency analysis indicated that approximately 1 in 12,500 peripheral B cells could give rise to these EBV-transformed B cell lines upon coculture with RA-NLC. These results indicate that RA-NLC from bone marrow and synovium have the capacity to rescue B cells from spontaneous apoptosis, facilitate Ig production, and promote the outgrowth of EBV-transformed B lymphoblastoid cells. These findings suggest that RA-NLC may play a role in the local and systemic hyperreactivity of B cells characteristic of rheumatoid arthritis.
Conflicts of Interest — Editorialists Respond
Authors: JoAnn E. Manson, Gerald A. Faich
Journal: New England Journal of Medicine (1996)

To the Editor: We appreciate the opportunity to present our perspective on the events surrounding the publication in the Journal of our editorial “Pharmacotherapy for Obesity — Do the Benefits Outweigh the Risks?” (Aug. 29 issue).1 We hope this letter will help clarify the genuine misunderstandings that occurred between us and the Journal editors. In June 1996, one of the editors of the Journal telephoned Dr. Manson to invite her to write an editorial to accompany an article on appetite suppressants and primary pulmonary hypertension.2 The written editorial policy of the Journal asked that authors “not have ongoing financial associations . . .
711 Pentoxifylline protects genetically obese mice from ethanol-induced hepatic apoptosis
Authors: M.A. Robin, C. Demeilliers, A. Sutton, V. Paradise, C. Maisonneuve, S. Dubois, O. Poirel, P. Lettéron, D. Pessayre, B. Fromenty
Journal: Journal of Hepatology (2006)
Association of elevated plasma anticholinergic activity with delirium in surgical patients
Authors: R C Golinger, T Peet, L E Tune
Journal: American Journal of Psychiatry (1987)

In a surgical intensive care unit, plasma anticholinergic activity was significantly higher in nine delirious patients than in 16 patients without delirium. The delirium may have been related to medications that are known to be associated with delirium and/or anticholinergic activity.