Metoclopramide Infusion with a Disposable Portable Pump
Authors: Eduardo Bruera, Neil Macdonald, Carleen Brenneis, Iain Simpson, Donald Legatt
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 June 1986Metoclopramide Infusion with a Disposable Portable PumpEDUARDO BRUERA, M.D., NEIL MACDONALD, M.D., F.R.C.P. (C), CARLEEN BRENNEIS, IAIN SIMPSON, DONALD LEGATT, Ph.D.EDUARDO BRUERA, M.D.Search for more papers by this author, NEIL MACDONALD, M.D., F.R.C.P. (C)Search for more papers by this author, CARLEEN BRENNEISSearch for more papers by this author, IAIN SIMPSONSearch for more papers by this author, DONALD LEGATT, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-6-896_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Chronic nausea and anorexia are frequent symptoms in patients with advanced cancer (1, 2). In patients who have no mechanical obstruction of the gastrointestinal tract or who are not receiving potentially emetogenic medication, the cause of these symptoms is generally unknown.Metoclopramide is an antidopaminergic agent that is useful for the treatment of chemotherapy-induced emesis and of nausea and anorexia associated with diabetes (3). Because of its short half-life (about 4 hours), we thought that a trial of metoclopramide by continuous infusion could eliminate the frequent peaks and troughs associated with oral medication, especially in patients with...References1. WALSH T and SAUNDERS C. Hospice care: the treatment of pain in advanced cancer. Recent Results Cancer Res. 1984;89:201-11. CrossrefMedlineGoogle Scholar2. BRUERA E, CARROW S, and ROCA E. Association between malnutrition and calorie intake, emesis, psychological depression, glucose, taste and tumor mass. Cancer Treat Rep. 1984;68:873-6. MedlineGoogle Scholar3. SCHULZE DELRIEU K. Metoclopramide. N Engl J Med. 1981;305:28-33. CrossrefMedlineGoogle Scholar4. BISHOP-FREUDLING G and VERGIN H. Determination of metoclopramide in human plasma by high-performance liquid chromatography. J Chromatogr. 1983;273:453-7. CrossrefMedlineGoogle Scholar5. CLARK R, KRIS M, and GRALLA R. Incidence and course of delayed emesis following high-dose cisplatin [Abstract]. Proc Am Soc Clin Oncol. 1985;4:267. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EDUARDO BRUERA, M.D.; NEIL MACDONALD, M.D., F.R.C.P. (C); CARLEEN BRENNEIS; IAIN SIMPSON; DONALD LEGATT, Ph.D.Affiliations: Cross Cancer Institute Edmonton, Alberta, Canada T6G 1Z2 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPalliative care and quality of lifeSubcutaneous Drugs and Off-label Use in Hospice and Palliative Care: A Scoping ReviewPalliative Care and Quality of LifePalliative Care and Quality of LifePalliative Care and Quality of LifeAn open study of methotrimeprazine in the management of nausea and vomiting in patients with advanced cancerCatabolic outcome from non-gastrointestinal malignancy-related malabsorption leading to malnutrition and weight lossLong-Term Safety and Clinical Effectiveness of Controlled-Release Metoclopramide in Cancer-Associated Dyspepsia Syndrome: A Multicentre EvaluationPain and Symptom Management in Palliative CareChronic nausea in advanced cancer patients: A retrospective assessment of a metoclopramide-based antiemetic regimenINTEGRATING MEDICAL AND SURGICAL TREATMENTS IN GASTROINTESTINAL, GENITOURINARY, AND BILIARY OBSTRUCTION IN PATIENTS WITH CANCERNutrition in cancer patientsComparison of the efficacy, safety, and pharmacokinetics of controlled release and immediate release metoclopramide for the management of chronic nausea in patients with advanced cancerSymptom control in terminally ill patients with malignant bowel obstruction (MBO)Ambulatory infusion devices in the continuing care of patients with advanced diseasesSubcutaneous infusions for control of cancer symptomsUse of the subcutaneous route for the administration of narcotics in patients with cancer painNutrition in cancer patients: an update and review of our experienceContinuous subcutaneous (SC) infusion of metoclopramide (MCP) using a plastic disposable infusor for the treatment of chemotherapy-induced emesisCancer Pain Management and Drug DeliveryNon-Gl-Malignancy-Related Malabsorption Leads to Malnutrition and Weight Loss 1 June 1986Volume 104, Issue 6Page: 896-896KeywordsGastrointestinal tractHalf lifeNausea ePublished: 1 December 2008 Issue Published: 1 June 1986 PDF downloadLoading ...