tbuckley/cabot-search huggingface dataset:
Decreased Reendothelialization and Increased Neointima Formation With Endostatin Overexpression in a Mouse Model of Arterial Injury
Authors: Randolph Hutter, Bernhard V. Sauter, Ernane D. Reis, Merce Roque, David Vorchheimer, Francine E. Carrick, John T. Fallon, Valentin Fuster, Juan J. Badimon
Journal: Circulation (2003)

Background— Impaired endothelial regeneration contributes to arterial lesion formation. Endostatin is a specific inhibitor of endothelial cell growth and induces endothelial cell apoptosis. We examined the effect of endostatin overexpression on reendothelialization and neointima formation in a mouse model of arterial injury. Methods and Results— Mice underwent femoral arterial denudation and received recombinant adenovirus, expressing either murine endostatin (n=19) or control adenoviral vector (n=12), by jugular vein injection. Endostatin gene transfer resulted in high serum levels of endostatin. Strong adenoviral gene expression of β-galactosidase–expressing control vector was detected in liver tissue and was absent in the injured arterial wall at 1 week. Deposits of endostatin protein were detected along the denuded arterial wall and were not seen in the noninjured contralateral artery at 1 week. Endostatin deposits were also absent in the injured artery of control vector–treated animals. Overexpression of endostatin led to decreased reendothelialization and increased apoptosis of luminal endothelial cells 2 and 4 weeks after arterial injury ( P &lt;0.05). In addition, endostatin overexpression resulted in increased neointima formation ( P &lt;0.05). Endothelial apoptosis and neointima area correlated positively with endostatin serum levels, whereas the degree of reendothelialization correlated negatively with endostatin serum levels ( P &lt;0.05). Furthermore, poor reendothelialization correlated with increased neointima formation ( P &lt;0.05). Conclusions— In summary, decreased reendothelialization and enhanced endothelial apoptosis, in response to endostatin overexpression, were associated with increased neointima formation. These findings demonstrate that high serum levels of endostatin are capable of inhibiting endothelial regeneration and promoting arterial lesion growth in conditions of endothelial injury.
Desloratadine treatment reduces systemic allergic inflammation following nasal allergen provocation in patients with allergic rhinitis and asthma*1
Authors: S.M. Reinartz, S.E. Overbeek, C.M. van Drunen, G.J. Braunstahl, H.C. Hoogsteden, W.J. Fokkens
Journal: Journal of Allergy and Clinical Immunology (2004)
Thirty-Day Results of the SAPIEN Aortic Bioprosthesis European Outcome (SOURCE) Registry
Authors: Martyn Thomas, Gerhard Schymik, Thomas Walther, Dominique Himbert, Thierry Lefèvre, Hendrik Treede, Holger Eggebrecht, Paolo Rubino, Iassen Michev, Rüdiger Lange, William N. Anderson, Olaf Wendler
Journal: Circulation (2010)

Transcatheter aortic valve implantation was developed to mitigate the mortality and morbidity associated with high-risk traditional aortic valve replacement. The Edwards SAPIEN valve was approved for transcatheter aortic valve implantation transfemoral delivery in the European Union in November 2007 and for transapical delivery in January 2008.The SAPIEN Aortic Bioprosthesis European Outcome (SOURCE) Registry was designed to assess the initial clinical results of the Edwards SAPIEN valve in consecutive patients in Europe after commercialization. Cohort 1 consists of 1038 patients enrolled at 32 centers. Patients who were treated with the transapical approach (n=575) suffered more comorbidities than the transfemoral patients (n=463), resulting in a significantly higher logistic EuroSCORE (29.1% versus 25.7%; P<0.001). Therefore, these groups are considered different, and outcomes cannot be compared. Overall short-term procedural success was observed in 93.8%. The incidence of valve embolization was 0.3% (n=3), and coronary obstruction was reported for 0.6% (n=6 cases). Incidence of stroke was 2.5% and similar for both procedural approaches. Thirty-day mortality was 6.3% in transfemoral patients and 10.3% in transapical patients. The occurrence of vascular complications was not a predictor of <30-day mortality in the transfemoral population.Technical proficiency can be learned and adapted readily as demonstrated by the short-term procedural success rate and low 30-day mortality rates reported in the SOURCE Registry. Specific complication management and refinement of patient selection are needed to further improve outcomes.
AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATT
Authors: ROBERT W. BUCK
Journal: Annals of Internal Medicine (1937)

Article1 September 1937AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATTTHE CLASS METHOD IN THE TREATMENT OF ESSENTIAL HYPERTENSION*ROBERT W. BUCK, M.D.ROBERT W. BUCK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-3-514 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWe are able to treat successfully such diseases as syphilis, allergic asthma or congestive heart failure because we have a good deal of accurate knowledge concerning their etiology and pathology; in the case of other conditions such as scurvy, malaria or pernicious anemia the lack of such knowledge did not prevent the discovery of a specific cure. Essential hypertension belongs to a third group of clinical entities, the etiology and pathology of which remain to a considerable extent obscure and for which there is no specific treatment. Fortunately perhaps, our profession has never permitted a deficiency in its knowledge of...References1. AYMAN D: An evaluation of therapeutic results in essential hypertension, Jr. Am. Med. Assoc., 1930, xcv, 246-249. CrossrefGoogle Scholar2. AYMANPRATT DJH: Nature of the symptoms associated with essential hypertension, Arch. Int. Med., 1931, xlvii, 675-687. CrossrefGoogle Scholar3. PRATT JH: The influence of emotions in the causation and cure of psychoneuroses, Internat. Clin., 1934, iv, Series 44, 1-16. Google Scholar4. HINDHEDE M: Das dänische Rationierungs-experiment, Skand. Arch. f. Physiol., 1925-6, xlvii, 102-120. Google Scholar5. JACOBSON E: You must relax, 1934, Whittlesey House, New York and London. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT W. BUCK, M.D.Affiliations: Boston, Massachusetts*Received for publication April 7, 1937. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBehavioral Approaches to HypertensionA little more than medicineSituation/transition groups: A conceptualization and review.Group Psychotherapy With Suicidal Persons: a Comparison With Standard Group MethodsGROUP PSYCHOTHERAPY IN BRONCHIAL ASTHMAShort-Term Group Therapy of Patients with Parkinson's DiseaseSOME INTERPERSONAL FACTORS IN ILLNESSThe blood pressure in essential hypertension: Effect of several reputedly hypotensive drugsPHYSIOLOGIC EFFECTS OF EXTENSIVE SYMPATHECTOMY FOR ESSENTIAL HYPERTENSION: FURTHER OBSERVATIONS*EDGAR V. ALLEN, M.D., F.A.C.P., ALFRED W. ADSON, M.D. 1 September 1937Volume 11, Issue 3Page: 514-518KeywordsAllergic diseasesAsthmaClinical pathologyEtiologyHeart diseasesHeart failureHypertensionMalariaPernicious anemiaSyphilis ePublished: 1 December 2008 Issue Published: 1 September 1937 PDF downloadLoading ...
Parents' difficulties and information needs in coping with acute illness in preschool children: a qualitative study
Authors: J. Kai
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objectives</b>: To identify and explore difficulties parents experience with acute illness in young children and the information they seek to help them. <b>Design</b>: Qualitative study using semistructured one to one and group interviews with parents of preschool children. <b>Setting</b>: Disadvantaged inner city community. <b>Subjects</b>: 95 parents of preschool children. <b>Results</b>: Parents felt disempowered when dealing with acute illness in their children because of difficulties making sense of the illness. Central to parents9 difficulties were their experiences of inadequate information sharing by their general practitioners and variations in their doctors9 decisions and behaviour. Disparity between parents9 beliefs and expectations about illness and treatment and professionals9 behaviour further frustrated parents9 attempts to understand illness. Parents expressed a need for a range of accessible and specific information to support them through their negotiation of children9s illness. <b>Conclusions</b>: Communication with parents requires greater recognition of parents9 difficulties. Professionals have considerable potential to empower parents by sharing more information and skills. Such information should be consistent and address parents9 concerns, beliefs, and expressed needs if this potential is to be realised. <h3>Key messages</h3> Greater recognition of parents9 difficulties may help to reduce potential disharmony between par- ents and doctors Attempts to share greater and consistent information may empower parents and should be sensitive to parents9 concerns, beliefs, and needs Tensions may arise for both parents and doctors if greater sharing of knowledge is accompanied by difficulties in tolerating and sharing uncertainty
Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors
Authors: Ruili Huang, Menghang Xia, Ming-Hsuang Cho, Srilatha Sakamuru, Paul Shinn, Keith A. Houck, David J. Dix, Richard S. Judson, Kristine L. Witt, Robert J. Kavlock, Raymond R. Tice, Christopher P. Austin
Journal: Environmental Health Perspectives (2011)

The large and increasing number of chemicals released into the environment demands more efficient and cost-effective approaches for assessing environmental chemical toxicity. The U.S. Tox21 program has responded to this challenge by proposing alternative strategies for toxicity testing, among which the quantitative high-throughput screening (qHTS) paradigm has been adopted as the primary tool for generating data from screening large chemical libraries using a wide spectrum of assays.The goal of this study was to develop methods to evaluate the data generated from these assays to guide future assay selection and prioritization for the Tox21 program.We examined the data from the Tox21 pilot-phase collection of approximately 3,000 environmental chemicals profiled in qHTS format against a panel of 10 human nuclear receptors (AR, ERα, FXR, GR, LXRβ, PPARγ, PPARδ, RXRα, TRβ, and VDR) for reproducibility, concordance of biological activity profiles with sequence homology of the receptor ligand binding domains, and structure-activity relationships.We determined the assays to be appropriate in terms of biological relevance. We found better concordance for replicate compounds for the agonist-mode than for the antagonist-mode assays, likely due to interference of cytotoxicity in the latter assays. This exercise also enabled us to formulate data-driven strategies for discriminating true signals from artifacts, and to prioritize assays based on data quality.The results demonstrate the feasibility of qHTS to identify the potential for environmentally relevant chemicals to interact with key toxicity pathways related to human disease induction.
Air Pollution as an Underappreciated Cause of Asthma Symptoms
Authors: George D. Thurston
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ANGIOGRAPHIC FEATURES RELATED TO INCOMPLETE STENT APPOSITION IN SPIRIT III TRIAL. A QUANTITATIVE ANALYSIS OF VESSEL CURVATURE
Authors: Moyses Oliveira Lima-Filho, Alexandra J. Lansky, Masao Yamasaki, Junya Ako, Andreas Wahle, Ping Yu, Takao Shimohama, Katsuhisa Waseda, Bon-Kwon Koo, Daysaku Nakatami, Hiromasa Otake, Yasuhiro Honda, Krishnankutty Sudhir, Gregg W. Stone, Peter J. Fitzgerald
Journal: Journal of the American College of Cardiology (2010)
Multivessel coronary angioplasty from 1980 to 1989: Procedural results and long-term outcome
Authors: James H. O'Keefe, Barry D. Rutherford, David R. McConahay, Warren L. Johnson, Lee V. Giorgi, Robert W. Ligon, Thomas M. Shimshak, Geoffrey O. Hartzler
Journal: Journal of the American College of Cardiology (1990)
Preliminary Evaluation of Four Oral Contraceptives Containing only Progestogens
Authors: E. Mears, M. P. Vessey, L. Andolsek, A. Oven
Journal: BMJ (1969)

One hundred and seventy-five women took part in a comparative clinical trial of four progestogen-only oral contraceptives and were followed for either a year or until treatment was discontinued. Megestrol acetate 0·25 mg. was found to be a very ineffective contraceptive, 21 out of 43 women becoming pregnant. One, three, and four pregnancies occurred during treatment with norethisterone acetate 0·3 mg., norgestrel 0·05 mg., and chlormadinone 0·5 mg., respectively, corresponding to pregnancy rates of 4, 9, and 12 per 100 woman-years of use. All three effective progestogens were very much less acceptable than modern low-dose combined oral contraceptives. Discontinuation of treatment for medical reasons (particularly menstrual disturbances) during the course of only one year affected 24% receiving norethisterone acetate, 38% receiving norgestrel, and 46% receiving chlormadinone.
Macrophage pacification reduces rodent pancreatitis-induced hepatocellular injury through down-regulation of hepatic tumor necrosis factor ? and interleukin-1?
Authors: Jun Yang, Woody Denham, Gay Carter, Kevin J. Tracey, James Norman
Journal: Hepatology (1998)

Overproduction of tumor necrosis factor α (TNF–α), interleukin–1β (IL–1β), and nitric oxide (NO) is believed to be detrimental during the progression of acute pancreatitis, yet little is known about the hepatic production of these mediators and their role in mediating pancreatitis–induced hepatic dysfunction. Rats were randomized to receive a single intraperitoneal injection of the macrophage–pacifying compound, CNI–1493 (1.0 mg/kg), or vehicle 1 hour before the induction of retrograde bile salt pancreatitis. Sham–operated animals served as controls. Animals were killed 18 hours later, with serum and livers harvested to determine the degree of hepatocellular injury and the induction of TNF–α, IL–1β, and inducible nitric oxide synthase (iNOS). In addition, serum TNF–α and nitrites (end–product of NO breakdown) were determined in each group to assess the mechanism of action of CNI–1493. TNF–α, IL–1β, and iNOS gene expression (by reverse–transcription polymerase chain reaction) as well as aspartate transaminase (AST), alanine transaminase (ALT), and lactic dehydrogenase (LDH) (but not alkaline phosphatase [ALP]) increased following the development of pancreatitis (all P &lt; .05). Macrophage pacification significantly prevented the induction of TNF–α and IL–1β mRNA (but not iNOS), resulting in lessened serum AST, ALT, and LDH (all P &lt; .05). Serum TNF–α protein and nitrites correlated with gene induction in that both were increased following the onset of pancreatitis, and TNF–α protein production was significantly attenuated in animals receiving CNI–1493. Hepatocellular, but not bile duct, injury occurs during experimental pancreatitis that is associated with hepatic TNF–α, IL–1β, and iNOS mRNA gene induction, as well as TNF–α protein and nitrite production. Preventing the production of TNF–α and IL–1β by macrophage pacification attenuates the hepatocellular damage, suggesting that these mediators play a role in pancreatitis–induced hepatic injury.
Practical Suggestions for Physicians Completing Medical Training and Entering Practice, Part 2
Authors: Patricia Tsang
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet
Authors: Gesine Saher, Fabian Rudolphi, Kristina Corthals, Torben Ruhwedel, Karl-Friedrich Schmidt, Siegrid Löwel, Payam Dibaj, Benoit Barrette, Wiebke Möbius, Klaus-Armin Nave
Journal: Nature Medicine (2012)
Dysregulation of granulocyte, erythrocyte, and NK cell lineages in Fli-1 gene–targeted mice
Authors: Masahiro Masuya, Omar Moussa, Takanori Abe, Takao Deguchi, Tsukasa Higuchi, Yasuhiro Ebihara, Demetri D. Spyropoulos, Dennis K. Watson, Makio Ogawa
Journal: Blood (2004)

Targeted disruption of the Friend leukemia integration 1 (Fli-1) proto-oncogene results in severe dysmegakaryopoiesis and embryonic lethality. We used morula-stage aggregation as a strategy to further clarify the hematopoietic defects of the Fli-1 gene-targeted mice. Analyses of lineage expression of Fli-1(+/-) and Fli-1(-/-) cells in the peripheral blood and bone marrow of chimeric mice consistently demonstrated reduced numbers of neutrophilic granulocytes and monocytes and increased numbers of natural killer (NK) cells. Transplantation studies using sorted Fli-1 mutant cells produced similar findings. Clonal culture studies of bone marrow cells revealed increased numbers of granulocytic and early erythroid progenitors in the Fli-1(+/-) cells. The sorted Fli-1(-/-) bone marrow cells revealed specific down-regulation of CCAAT/enhancer binding protein-alpha (C/EBPalpha) and C/EBPepsilon, and the receptors for granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage CSF (GM-CSF), consistent with their critical roles in granulopoiesis. Collectively, these observations suggest previously unknown physiologic roles for Fli-1 in granulocytic, erythroid, and NK cell proliferation and differentiation. Production of chimeras by morula-stage embryo aggregation is an effective way to unravel cell-autonomous hematopoietic defects in gene-targeted mice.
A Randomized Comparison of Clopidogrel and Aspirin Versus Ticlopidine and Aspirin After the Placement of Coronary-Artery Stents
Authors: Christian Müller, Heinz J. Büttner, Jens Petersen, Helmut Roskamm
Journal: Circulation (2000)

Background —The introduction of an effective antiplatelet therapy with aspirin and ticlopidine after the placement of coronary-artery stents has decreased the risk of thrombotic stent occlusions (TSO) and hemorrhagic complications. However, the use of ticlopidine is limited by hematological and gastrointestinal adverse effects. The safety and efficacy of clopidogrel after stenting remains to be established. Methods and Results —After successful coronary stenting during elective or emergency percutaneous transluminal coronary angioplasty, 700 patients with 899 lesions were randomly assigned to receive a 4-week course of either 500 mg ticlopidine (n=345) or 75 mg clopidogrel (n=355), in addition to 100 mg aspirin. All the following clinical events reflecting TSO were included in the prespecified primary cardiac endpoint: cardiac death, urgent target vessel revascularization, angiographically documented TSO, or nonfatal myocardial infarction within 30 days. The primary noncardiac endpoint was defined as noncardiac death, stroke, severe peripheral vascular or hemorrhagic events, or any adverse event resulting in discontinuation of study medication. Cardiac events occurred in 17 patients [11 (3.1%) with clopidogrel and 6 (1.7%) with ticlopidine ( P =0.24)]. The primary noncardiac endpoint was observed in 16 patients (4.5%) assigned to receive clopidogrel versus 33 patients (9.6%) assigned to receive ticlopidine ( P =0.01). Conclusions —After the placement of coronary-artery stents in unselected patients, antiplatelet therapy with aspirin and clopidogrel seems to be comparably safe and effective as aspirin and ticlopidine. Noncardiac events were significantly reduced with clopidogrel.
LACTIC-ACID BACILLUS SPRAY FOR DIPHTHERIA
Authors: HAROLD B. WOOD
Journal: JAMA (1913)

A spray of lactic acid bacilli was recently used in available diphtheria cases in Rochester with the view of clearing up refractive diphtheria carriers and in an attempt to find for spraying some organism which is not foreign to human tissues and is not regarded as pathogenic. The success was rapid and marked, but with only a few trials no definite statements can be made. This suggestion is hereby offered that others may try the lactic acid bacillus spray, as the staphylococcus is now being used for overriding local bacterial infections, so that its usefulness may be measured or the inadvisability of its use demonstrated. Four cases of diphtheria appeared in the Rochester State Hospital for the Insane between Jan. 18 and Feb. 9, 1913. The last patient, a nurse in the isolation infirmary, showed no symptoms and was a secondary case. The other three patients, two of them nurses,