tbuckley/cabot-search huggingface dataset:
Abstract 2839: NK cell response and tumor debulking are associated to prolonged survival in recurrent glioblastoma treated by dendritic cells loaded with autologous tumor lysate.
Authors: Serena Pellegatta, Marica Eoli, Simona Frigerio, Carlo Antozzi, Maria Grazia Bruzzone, Gabriele Cantini, Sara Nava, Elena Anghileri, Lucia Cuppini, Valeria Cuccarini, Emilio Ciusani, Marta Dossena, Bianca Pollo, Renato Mantegazza, Eugenio A. Parati, Gaetano Finocchiaro
Journal: Cancer Research (2013)

Abstract Recurrent glioblastoma (GB) are highly aggressive tumors allowing 6-8 month survival. Here we evaluated the possible benefits of immunotherapy with mature dendritic cells (DC) loaded with autologous tumor lysate in 15 patients with recurrent GB. After a median follow-up of 8 months median progression free survival (PFS) was 4.4 months and median overall survival (OS) 8.0 months. Patients with small tumors at first vaccination (&amp;lt; 20 cc; n = 8) had significantly longer PFS and OS than others: 6.0 vs 3.0 months (p = 0.01) and 16.5 vs 7.0 months (p = 0.003), respectively. Patients were analysed for CD8+ T cells, CD56+ NK cells and other relevant immunological parameters in peripheral blood before and after immunization, defining a vaccination/baseline ratio (V/B ratio). Increased V/B ratio of NK but not CD8+ T cells was significantly associated to longer PFS and OS. Patients showing NK cell responses had higher levels of IFN-γ and E4BP4, the NK cell transcription factor. Furthermore, NK V/B ratio was inversely correlated with TGF-β2 and VEGF V/B ratio. The results suggest that tumor-loaded DC may increase survival of recurrent GB after effective tumor debulking and emphasize the role of NK cell responses in this therapeutic setting. Citation Format: Serena Pellegatta, Marica Eoli, Simona Frigerio, Carlo Antozzi, Maria Grazia Bruzzone, Gabriele Cantini, Sara Nava, Elena Anghileri, Lucia Cuppini, Valeria Cuccarini, Emilio Ciusani, Marta Dossena, Bianca Pollo, Renato Mantegazza, Eugenio A. Parati, Gaetano Finocchiaro. NK cell response and tumor debulking are associated to prolonged survival in recurrent glioblastoma treated by dendritic cells loaded with autologous tumor lysate. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2839. doi:10.1158/1538-7445.AM2013-2839 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
A Laser-Endoscope with Direct Beam Coupling
Authors: J. Eichler, K. Gutsche, J. Knof, H. Lenz, J. Salk, G. Schäfer
Journal: Endoscopy (1978)

An optical element for direct laser-beam coupling into the observation optic of a rigid endoscope was developed. Using this coupling element every suitable endoscope can be modified into a laser endoscope which can be used for laser surgery e.g. in ENT and urology. The requirements for the endoscope and the optical coupling element are discussed.
Health Effects of the Gulf Oil Spill
Authors: Gina M. Solomon
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
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Authors: Robert M. Kalus, Kaveh G. Shojania, John K. Amory, Sanjay Saint
Journal: New England Journal of Medicine (2006)

Urinary urgency and fever developed in a 55-year-old, bedridden woman with multiple sclerosis, a long-term indwelling Foley catheter, and multiple prior urinary tract infections. The patient had recently been transferred from an assisted-living facility to a skilled-nursing facility because of progressive disability. The laboratory evaluation revealed pancytopenia.
Antibodies to spermatozoa.
Authors: R Crozier
Journal: BMJ (1977)

Immunological aspects of vasectomy are discussed. An 86% incidence of sperm antibodies has been reported in children. Presumablly, these antibodies arise from exposure to infectious microorganisms, not to sperm. It has been reported that sperm antibodies occur in low titers in 2-5% of men before vasectomy and in higher titers in 55-75% of men within 1 year after vasectomy. Similarly, spermimmobilizing antibodies are found in low titers in 1-2% of men prior to vasectomy and in higher titers in 30-60% of men after vasectomy. Immunofluorescence has also shown increased titers of other antibodies after vasectomy. It is likely that the immune responses to sperm may result from smal ruptures of the occluded epididymis or vas with subsequent sperm granuloma formation, rather than from inflammatory or atrophic changes in the testis following vasectomy. Immune complex disease of the testis and kidney has been found in vasectomized rabbits with high antibody titers.
From Mice and Men to Earth and Space: Joint NASA–NCI Workshop on Lung Cancer Risk Resulting from Space and Terrestrial Radiation
Authors: Jerry W. Shay, Francis A. Cucinotta, Frank M. Sulzman, C. Norman Coleman, John D. Minna
Journal: Cancer Research (2011)

On June 27-28, 2011, scientists from the National Cancer Institute (NCI), NASA, and academia met in Bethesda to discuss major lung cancer issues confronting each organization. For NASA, available data suggest that lung cancer is the largest potential cancer risk from space travel for both men and women and quantitative risk assessment information for mission planning is needed. In space, the radiation risk is from high energy and charge (HZE) nuclei (such as Fe) and high-energy protons from solar flares and not from gamma radiation. In contrast, the NCI is endeavoring to estimate the increased lung cancer risk from the potential widespread implementation of computed tomographic (CT) screening in individuals at high risk for developing lung cancer based on the National Lung Cancer Screening Trial (NLST). For the latter, exposure will be X-rays from CT scans from the screening (which uses "low-dose" CT scans) and also from follow-up scans used to evaluate abnormalities found during initial screening. Topics discussed included the risk of lung cancer arising after HZE particle, proton, and low-dose exposure to Earth's radiation. The workshop examined preclinical models, epidemiology, molecular markers, "omics" technology, radiobiology issues, and lung stem cells that relate to the development of lung cancer.
Emotion theory is about more than affect and cognition: Taking triggers and actions into account
Authors: Charles S. Carver
Journal: Behavioral and Brain Sciences (2005)

Understanding how emotions emerge is difficult without determining what characteristic of the trigger actually triggers them. Knowing whether emotional experiences self-stabilize is difficult without remembering what other processes are set in play as the emotion emerges. It is not clear either that positive feedback is required for the emergence of emotion or that an attractor model captures well what is happening when an emotion arises.
Burden of corticosteroids in children with asthma in primary care: retrospective observational study
Authors: S. Ekins-Daukes
Journal: BMJ (2002)

In primary care, asthma and rhinitis are common paediatric comorbidities for which long term inhaled or nasal corticosteroid may be prescribed.Atopic children may receive both, resulting in high cumulative doses of topical corticosteroids and increasing the risk of adverse effects.From 185 general practices in Scotland, we identified the number of children who were chronically prescribed both an inhaled and a nasal corticosteroid and calculated their total daily steroid burden between 1 November 1999 and 31 October 2000.
Nomograms for Calculation of Heat Loss
Authors: F. House, R. Vale
Journal: BMJ (1972)

Two nomograms are presented. The first enables the mean surface and body temperatures and the body heat content of a patient of given weight to be determined from measurements of skin temperature at three sites and of the core (rectal) temperature. The second enables the change in heat content of such a patient to be determined from the change in mean body temperature.
Influence of Previous Chemotherapy on the Efficacy of Subsequent Docetaxel Therapy in Advanced Non-small Cell Lung Cancer Patients
Authors: Yasushi Goto, Ikuo Sekine, Kazuhiko Yamada, Hiroshi Nokihara, Noboru Yamamoto, Hideo Kunitoh, Yuichiro Ohe, Tomohide Tamura
Journal: Journal of Thoracic Oncology (2008)
The Ets-1 transcription factor is required for Stat1-mediated T-bet expression and IgG2a class switching in mouse B cells
Authors: Hai Vu Nguyen, Enguerran Mouly, Karine Chemin, Romain Luinaud, Raymonde Despres, Jean-Paul Fermand, Bertrand Arnulf, Jean-Christophe Bories
Journal: Blood (2012)
Were James Bond's drinks shaken because of alcohol induced tremor?
Authors: G. Johnson, I. N. Guha, P. Davies
Journal: BMJ (2013)

<b>Objective</b> To quantify James Bond's consumption of alcohol as detailed in the series of novels by Ian Fleming. <b>Design</b> Retrospective literature review. <b>Setting</b> The study authors' homes, in a comfy chair. <b>Participants</b> Commander James Bond, 007; Mr Ian Lancaster Fleming. <b>Main outcome measures</b> Weekly alcohol consumption by Commander Bond. <b>Methods</b> All 14 James Bond books were read by two of the authors. Contemporaneous notes were taken detailing every alcoholic drink taken. Predefined alcohol unit levels were used to calculate consumption. Days when Bond was unable to consume alcohol (such as through incarceration) were noted. <b>Results</b> After exclusion of days when Bond was unable to drink, his weekly alcohol consumption was 92 units a week, over four times the recommended amount. His maximum daily consumption was 49.8 units. He had only 12.5 alcohol free days out of 87.5 days on which he was able to drink. <b>Conclusions</b> James Bond's level of alcohol intake puts him at high risk of multiple alcohol related diseases&nbsp;and an early death. The level of functioning as displayed in the books is inconsistent with the physical, mental, and indeed sexual functioning expected from someone drinking this much alcohol. We advise an immediate referral for further assessment and treatment, a reduction in alcohol consumption to safe levels, and suspect that the famous catchphrase "shaken, not stirred" could be because of alcohol induced tremor affecting his hands.
Unusual effect of fenfluramine.
Authors: I Oswald
Journal: BMJ (1969)

cancer discovered by miniature mass radio- graphy.Of course, mass radiography has widened its scope since its introduction in the early1940s.It has become a service, a tool for presymptomatic diagnosis.X-ray depart- ments in hospitals are neither meant nor equipped to do this.To destroy such a service without even taking regional differences and problems into consideration is a retrograde step.-Iam, etc.,
Review: In sepsis, the effect of resuscitation with crystalloid and colloid fluids on mortality varies
Authors: Sameer S. Kadri, Robert L. Danner
Journal: Annals of Internal Medicine (2014)

Source Citation Rochwerg B, Alhazzani W, Sindi A, et al; Fluids in Sepsis and Septic Shock Group. Fluid resuscitation in sepsis: a systematic review and network meta-analysis. Ann Intern Med. 2014;161:347-55. 25047428
Childhood antecedents of schizophrenia and affective illness: social adjustment at ages 7 and 11
Authors: D J Done, T J Crow, E C Johnstone, A Sacker
Journal: BMJ (1994)

<h3>Abstract</h3> <b>Objective</b>: To investigate the social adjustment in childhood of people who as adults have psychiatric disorders. Design - Subjects in a prospectively followed up cohort (the national child development study) who had been admitted as adults to psychiatric hospitals were compared with the rest of the cohort on ratings of social behaviour made by teachers at the ages of 7 and 11 years. <b>Subjects</b>: 40 adult patients with schizophrenic illnesses, 35 with affective psychoses, and 79 with neurotic illness who had been admitted for psychiatric reasons by the age of 28. 1914 randomly selected members of the cohort who had never been admitted for psychiatric treatment. <b>Main outcome measures</b>: Overall scores and scores for overreaction (externalising behaviour) and underreaction (internalising behaviour) with the Bristol social adjustment guide at ages 7 and 11. <b>Results</b>: At the age of 7 children who developed schizophrenia were rated by their teachers as manifesting more social maladjustment than controls (overall score 4.3 (SD 2.4) v 3.1 (2.0); P &lt;0.01). This was more apparent in the boys (5 (2.6)) than the girls underreactive behaviour. At both ages prepsychotic (affective) children differed little from normal controls. By the age of 11 preneurotic children, particularly the girls, had an increased rating of maladjustment (including overreactions and underreactions). <b>Conclusion</b>: Abnormalities of social adjustment are detectable in childhood in some people who develop psychotic illness. Sex and the rate of development of different components of the capacity for social interaction are important determinants of the risk of psychosis and other psychiatric disorders in adulthood.
Domiciliary thrombolysis by general practitioners.
Authors: A. C. Pell, K. A. Fox
Journal: BMJ (1992)

61, 62, and 63). Also, three of our patients who were operated on had small aneurysms initially that grew by over 1 cm in six months, a far quicker rate of growth than that described by others in nonhypertensive patients.On the basis of our initial findings we believe that screening should be offered to male hypertensive patients from the age of 60 and should be done regularly-for example, every three to five years-in this group.In the 388 women we have screened eight aneurysms have been detected (only two over 3 5 cm), confirming the low incidence ofaneurysms in women described by others.3One woman, aged 72, has required an elective repair of an aneurysm of 6 1 cm.Many more hypertensive women will require screening to determine more precisely the lower incidence of aneurysms in this group.Offering screening in some form to this group may well, however, prove to be just as economical as breast cancer screening, in terms of quality adjusted life years at least.Numerous studies have suggested an association between hypertension and abdominal aortic aneurysms.We believe that hypertensive people also "require special provision for screening irrespective of any plans to screen apparently healthy people."
Determination of Osmotic Pressure in Diabetes Insipidus
Authors: Leonard S. Dreifus, Martin N. Frank, Samuel Bellet
Journal: New England Journal of Medicine (1954)

The object of this communication is to report a relatively simple test for the diagnosis of diabetes insipidus: the simultaneous determination of the osmotic pressure of the blood and urine. Diabetes insipidus may be suspected in a patient with polyuria and polydipsia whose urine is consistently of low specific gravity. This syndrome must be differentiated from psychogenic polydipsia with polyuria, "chronic nephritis" and diabetes mellitus. The last two should present no difficulty in differential diagnosis with the aid of ordinary laboratory tests.Certain procedures that aid in the diagnosis of diabetes insipidus are as follows: alleviation of symptoms after the . . .
Direct comparison of electron beam tomography and dobutamine stress echocardiography for the detection of significant coronary artery disease
Authors: Dieter Ropers, Stephan Achenbach, Clarissa Kuefner, Theresa Menéndez, Karsten Pohle, Tom Giesler, Frank A. Flachskampf, Werner G. Daniel, Werner Moshage, Uwe Nixdorff
Journal: Journal of the American College of Cardiology (2002)
Ventricular overdrive suppression of idioventricular rhythm in patients with complete heart block
Authors: G. K. LANE, B. M. KENNELLY
Journal: Cardiovascular Research (1978)

Idioventricular rate, QRS width, site of block and responses to ventricular overdrive pacing were studied in 29 patients with chronic complete heart block in an attempt to distinguish patients liable to syncopal attacks. Ten patients were asymptomatic, 5 gave a history of presyncope and 14 of syncope. Although the mean idioventricular rate of the 10 patients in the narrow QRS group (40.0 per min) was significantly faster than that of the 19 patients in the wide QRS group (35.5 per min; P less than 0.02), the rate did not distinguish symptomatic patients in either the narrow or the wide QRS groups. His bundle studies of the site of block were also unhelpful. Overdrive right ventricular pacing at increasing rates was used to assess ventricular escape times which were not significantly different in symptomatic and asymptomatic wide QRS patients. There was, however, a significant difference in the product of maximum ventricular escape time X overdrive cycle length between symptomatic and asymptomatic narrow QRS patients after 30 s overdrive (3.850+/-1.670 vs 1.070+/-0.475; P less than 0.01); 60 s overdrive (5.020+/-2.170 vs 1.240+/-0.515; P less than 0.01) and 120 s overdrive (6.040+/-2.900 vs 1.460+/-0.275; P less than 0.01) which may have clinical predictive values.
Could Aspirin Really Prevent Colon Cancer?
Authors: John A. Baron, E. Robert Greenberg
Journal: New England Journal of Medicine (1991)

IN the United States, tumors of the colon and rectum account for approximately 15 percent of all visceral cancers and about 12 percent of all deaths from cancer. During the past several decades, the incidence of these cancers has remained relatively constant, and the associated mortality has declined only slightly, despite intensive attempts at earlier detection and better treatment. Research into ways to lessen the incidence or mortality has yielded only equivocal results. In several large ongoing studies conducted for up to 12 years, no clear reduction in mortality has resulted from screening for occult blood in feces.1 Among the . . .
Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin αMβ2 binding motif
Authors: Matthew J. Flick, Christine M. LaJeunesse, Kathryn E. Talmage, David P. Witte, Joseph S. Palumbo, Malinda D. Pinkerton, Sherry Thornton, Jay L. Degen
Journal: Journal of Clinical Investigation (2007)

Fibrin deposition within joints is a prominent feature of arthritis, but the precise contribution of fibrin(ogen) to inflammatory events that cause debilitating joint damage remains unknown. To determine the importance of fibrin(ogen) in arthritis, gene-targeted mice either deficient in fibrinogen (Fib–) or expressing mutant forms of fibrinogen, lacking the leukocyte receptor integrin αMβ2 binding motif (Fibγ390–396A) or the αIIbβ3 platelet integrin-binding motif (FibγΔ5), were challenged with collagen-induced arthritis (CIA). Fib– mice exhibited fewer affected joints and reduced disease severity relative to controls. Similarly, diminished arthritis was observed in Fibγ390–396A mice, which retain full clotting function. In contrast, arthritis in FibγΔ5 mice was indistinguishable from that of controls. Fibrin(ogen) was not essential for leukocyte trafficking to joints, but appeared to be involved in leukocyte activation events. Fib– and Fibγ390–396A mice with CIA displayed reduced local expression of TNF-α, IL-1β, and IL-6, which suggests that αMβ2-mediated leukocyte engagement of fibrin is mechanistically upstream of the production of proinflammatory mediators. Supporting this hypothesis, arthritic disease driven by exuberant TNF-α expression was not impeded by fibrinogen deficiency. Thus, fibrin(ogen) is an important, but context-dependent, determinant of arthritis, and one mechanism linking fibrin(ogen) to joint disease is coupled to αMβ2-mediated inflammatory processes.
Prevalence, Detection and Referral of Psychiatric Morbidity in General Medical Patients
Authors: A Seltzer
Journal: Journal of the Royal Society of Medicine (1989)

Twenty seven per cent of medical emergency admissions were found to have diagnosable psychiatric disorders, mostly mild. Although ward staff assessed 31.1% of admissions as having emotional or psychological problems, only a minority had diagnosable psychiatric disorders. Few patients were referred for specialist psychiatric help. This partly reflected the milder nature of problems identified by ward staff, and partly indifference to psychiatry.
Differential lymphotoxin-? and interferon gamma signaling during mouse liver regeneration induced by chronic and acute injury
Authors: Barbara Akhurst, Vance Matthews, Kirsten Husk, Mark J. Smyth, Lawrence J. Abraham, George C. Yeoh
Journal: Hepatology (2005)

The liver regenerates after acute injury via hepatocyte cell division; during chronic injury, when hepatocyte replication is impaired or blocked, liver progenitor oval cells mediate liver regeneration. If both regeneration options are blocked in animal models, then liver failure and death ensues. The mechanisms underlying oval cell induction, proliferation, and subsequent liver regeneration remain poorly characterized. In particular, cell-signaling pathways that distinguish the alternative pathways are unknown. This study shows that in a mouse model, hepatic expression of lymphotoxin-beta (LTbeta) and interferon gamma (IFNgamma) transcripts is increased in response to the choline-deficient, ethionine-supplemented (CDE) diet, which induces oval cell-mediated liver regeneration. Oval cells express LTbeta and IFNgamma transcripts, contributing to the increased expression in the liver of mice fed the CDE diet. An attenuated oval cell response to such a diet was observed in LTbeta receptor-, LTbeta-, and IFNgamma-gene targeted mice. Loss of LTbeta and LTbeta receptor signaling reduced the number of oval cells expressing A6 and muscle pyruvate kinase. The lack of IFNgamma signaling reduced muscle pyruvate kinase(+), but not A6(+), oval cells. In contrast, partial hepatectomy suppressed LTbeta and IFNgamma transcripts. We also show that IFNgamma induces STAT-3 phosphorylation in an oval cell line. In conclusion, LTbeta, LTbeta receptor, and IFNgamma are involved in oval cell-mediated, but not hepatocyte-mediated, liver regeneration, and the absence of these pathways impairs the oval cell-dependent regenerative response.
A Simple and Inexpensive Screening Test for Sickle Hemoglobin
Authors: Mortimer S. Greenberg, Harold A. Harvey, Charles Morgan
Journal: New England Journal of Medicine (1972)

APPROXIMATELY 8.5 per cent of black Americans have sickle-cell trait.1 There has been considerable recent interest in identifying these people so that they can be educated regarding sickle-cell disease and offered genetic counseling. Three screening tests are now available for identifying the presence of sickle hemoglobin in small samples of blood. The sodium metabisulfite sickling preparation2 and the slide elution technic of Yakulis and Heller3 require a microscope to read the results. The solubility test described by Ballard et al.4 has the advantage that it can be done in the field without a microscope but is prohibitively expensive for large . . .