tbuckley/cabot-search huggingface dataset:
Treatment of Thyrotoxicosis
Authors: J. DAVID BERNARD
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 October 1984Treatment of ThyrotoxicosisJ. DAVID BERNARD, M.D.J. DAVID BERNARD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-4-573_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The recent article by Dunn (1) has produced mixed emotions in this reader. At first, I was merely astounded; rereading and consideration of the facts and conclusions produced confusion and uneasiness followed by my current feelings of mild displeasure.I have rendered care to some 700 thyrotoxic persons in 19 years of the practice of endocrinology and nuclear medicine, and although there have been some philosophical changes in the primary management of thyrotoxicosis over this period, therapy selection is certainly no problem for me in 1984. That radioiodine is the most effective, safest, and probably most economical...Reference1. DUNN J. Choice of therapy in young adults with hyperthyroidism of Graves' disease: a brief, case-directed poll of fifty-four thyroidologists. Ann Intern Med. 1984;100:891-3. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: 1617 N. California Street, Suite Z-E; Stockton, CA 95204 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1984Volume 101, Issue 4Page: 573-573KeywordsEmotionsEndocrinology Issue Published: 1 October 1984 PDF DownloadLoading ...
Hsp27 Modulates p53 Signaling and Suppresses Cellular Senescence
Authors: Cornelia O'Callaghan-Sunol, Vladimir L. Gabai, Michael Y. Sherman
Journal: Cancer Research (2007)

Abstract The small heat shock protein Hsp27 is expressed at high levels in many tumors and provides protection against anticancer drugs. Here, we show that expression of recombinant Hsp27 at elevated levels leads to protection of MCF10A human mammary epithelial cells from doxorubicin. The protection was associated with suppression of the doxorubicin-induced senescence, where Hsp27 inhibited p53-mediated induction of p21, the major regulator of the senescence program. Similarly, Hsp27 inhibited accumulation of p21 and suppressed senescence in response to the p53 activator nutlin-3, indicating that Hsp27 has a general effect on the p53 pathway. In line with these findings, down-regulation of Hsp27 in HCT116 human colon carcinoma cells that express this heat shock protein at high levels caused senescence in a population of cells and sensitized the rest of the cells to doxorubicin-induced senescence (at low doses) or apoptosis (at high doses of doxorubicin). Induction of senescence by Hsp27 down-regulation associated with activation of the p53 pathway and induction of p21. Interestingly, depletion of Hsp27 caused neither significant proteotoxic nor genotoxic stress, and therefore this heat shock protein seems to have a specific effect on the p53 signaling. Indeed, Hsp27 down-regulation was associated with destabilization of HDM2 and stabilization of p53. These data suggest that Hsp27 may play a general role in regulation of cellular senescence by modulating the p53 pathway. [Cancer Res 2007;67(24):11779–88]
Renal Response to Captopril in Severe Heart Failure: Role of Furosemide in Natriuresis and Reversal of Hyponatremia
Authors: Victor J. Dzau, Norman K. Hollenberg
Journal: Annals of Internal Medicine (1984)

To assess the effect of furosemide and captopril on renal function and hyponatremia in patients with severe heart failure, we studied two groups of patients with hyponatremia who were receiving digoxin therapy and whose sodium intake was 40 meq/d. One group received captopril and furosemide, the second received captopril. The first group responded to combination therapy with a brisk natriuresis and diuresis, weight reduction, and an increase in serum sodium concentration. Patients who received captopril alone did not respond, despite a similar increase in renal plasma flow and glomerular filtration rate. When furosemide was then administered to patients who had received captopril alone, a brisk natriuresis, weight loss, and correction of hyponatremia followed. Treatment with furosemide is necessary to promote natriuresis and correction of hyponatremia in patients with severe heart failure treated with captopril; the renal vascular action of captopril enhances the effectiveness of furosemide.
An evaluation of right and left ventricular function after anatomical correction and intra-atrial repair operations for complete transposition of the great arteries.
Authors: R P Martin, S A Qureshi, J A Ettedgui, E J Baker, B J O'Brien, P B Deverall, A K Yates, M N Maisey, R Radley-Smith, M Tynan
Journal: Circulation (1990)

Anatomical correction of complete transposition of the great arteries has the potential advantage over intra-atrial repair in that the left ventricle becomes the systemic pump. To investigate the importance of this, we evaluated right and left ventricular function in 21 patients after anatomical correction and in 21 patients after Mustard or Senning operations. First-pass and equilibrium-gated radionuclide angiography were used to measure right and left ventricular ejection fractions between 17 and 78 (mean, 47) months after anatomical correction and between 3 and 187 (mean, 67) months after intra-atrial repair. The mean age of the patient groups at the time of study was 52 and 84 months, respectively. The right ventricular ejection fraction ranged from 35% to 78% (mean, 58%) in patients after anatomical correction and from 27% to 68% (mean, 51%) after intra-atrial repair (p = 0.066). The left ventricular ejection fraction ranged from 39% to 74% (mean, 58%) after anatomical correction and from 35% to 74% (mean, 58%) after intra-atrial repair (p = 0.86). The mean right and left ventricular ejection fractions of both groups were significantly lower than those of normal children. Individuals with systemic ventricular dysfunction were identified after both types of operations; however, symptomatic dysfunction occurred only after intra-atrial repair (p = 0.24).
Transient QRS changes simulating acute myocardial infarction.
Authors: M A Hassett, R R Williams, G S Wagner
Journal: Circulation (1980)

The purpose of this study was to determine the characteristics and incidence of abrupt occurrence of abnormal initial QRS forces that cannot be explained by acute myocardial infarction or left or right ventricular overload. Computerized data from 3175 patients with suspected acute infarction were reviewed to identify those in whom the ECGs revealed QRS complexes considered to be diagnostic (Q wave or markedly diminished R wave) in the presence of persistently normal profiles of both creatine kinase and lactic dehydrogenase isoenzymes. Lead misplacement had been minimized by obtaining multispace tracings and vectorcardiograms. Eight patients (0.25%) were identified. The abnormal forces were confined to leads V 1-3 in six, V 4-6 in one, and involved all precordial leads in the last. These QRS changes resolved completely within 6 days in all eight patients, which suggests that they did not have an acute infarction. This theory was supported by postmortem examination in one patient. An extremely low incidence (0.25%) has been documented for a syndrome characterized by transient loss of initial anterior forces with persistently normal isoenzyme profiles. Although no etiology could be determined, a transient conduction block of the septal fascicle of the left bundle could have been the cause in seven of the eight patients.
Adriamycin and Radiation Reactions
Authors: F. Anthony Greco, Robert K. Oldham
Journal: Annals of Internal Medicine (1977)

Comments and Correction1 May 1977Adriamycin and Radiation ReactionsF. ANTHONY GRECO, M.D., ROBERT K. OLDHAM, M.D.F. ANTHONY GRECO, M.D.Search for more papers by this author, ROBERT K. OLDHAM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-5-655 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the September issue (Ann Intern Med85:294-298, 1976) Greco and associates reported that combination chemotherapy with adriamycin enhanced radiation reactions in skin and esophagus in 10 patients receiving concurrent therapy for small-cell anaplastic carcinoma of the lung. These observations were made in 1975. Two other reports have been published on these same patients, plus about 12 others from the National Institutes of Health (NIH) (1, 2). These reports and unpublished results from 48 patients treated at Vanderbilt University Medical Center help shed additional light on the true frequency, severity, and cause of esophageal and skin reactions....References1. MERRILLBRERETONKENT JHC: Anorectal disease in patients with non-haematologized malignancy. Lancet 1:1105-1107, 1976 CrossrefMedlineGoogle Scholar2. JOHNSONBRERETONKENT RHC: Small-cell carcinoma of the lung: attempt to remedy causes of past therapeutic failure. Lancet 2:289-291, 1976 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRadiation recall reaction with anastrozole treatment in breast cancerAn Ambiguous Phenomenon of Radiation and Drugs: Recall ReactionsHydroxyalkylation of parabanic acid. III. Polymers from parabanic acid and ethylene carbonateRespiratory Failure and Mechanical Ventilation in Cancer PatientsCharacterizing the phenomenon of radiation recall dermatitisCombined modality treatment for resected advanced non-small cell lung cancer: local control and local recurrenceSmall Cell Lung CancerMuscular pseudotumor of the breast following doxorubicin and radiation therapy for oat cell carcinoma of the lung 1 May 1977Volume 86, Issue 5Page: 655-656KeywordsCombination chemotherapyEsophagusLung and intrathoracic tumorsRadiation therapySkin reaction Issue Published: 1 May 1977 PDF DownloadLoading ...
Letter: Nicotine, tobacco substitutes, and smoking habits.
Authors: R G Rawbone
Journal: BMJ (1976)

dysfunction, thyroid disease, and hyperpro- lactinaemia.Five of these patients, who were excluded from the trial, recovered their potency when the underlying abnormality was treated, although they had failed to respond to previous androgen supplements.These patients often felt physically well and had similar putative aetiological factors which were indistinguishable from those in patients with no physical abnormality.In other words they had their fair share of factors regarded as important in aetiology by Masters and Johnson2-acute alcoholic episodes, marital
Disappearing Plastic Cannula
Authors: E. B. Lewis
Journal: BMJ (1964)

From the history and clinical findings of the case it was possible to say that the fungus was first inoculated into the skin.Later the organism involved the subcutaneous fatty tissue and produced nodules akin to those seen in the peritoneum.The culture studies suggested that pathogenicity of the fungus mainly depended on the presence of the periodic-acid-Schiff-positive material.-Iam, etc
Colonic Obstruction
Authors: A. Rubin
Journal: JAMA (1983)

<h3>History</h3> This 46-year-old man, admitted to the psychiatric service, was given amitriptyline hydrochloride, 125 mg daily, for depression. Six days later, nausea, vomiting, abdominal tenderness, and progressive distention of the abdomen developed. No bowel movement had occurred for two days. An anteroposterior roentgenogram of the abdomen demonstrated a large pelvic mass (Fig 1) with dilated large bowel. A prone horizontal-beam roentgenogram showed multiple airfluid levels, indicating large-bowel obstruction (Fig 2). An emergency barium enema examination showed a large mass compressing the colon extrinsically. The lumen of the sigmoid colon was narrowed and the mucosa appeared irregular, suggesting transmural involvement (Fig 3). Catheterization of the urinary bladder evacuated approximately 2.3 L of urine, and the signs and symptoms of intestinal obstruction disappeared. A postcatheterization barium enema examination outlined a normal colon. <h3>Diagnosis</h3> Mechanical obstruction of the sigmoid colon secondary to distention of the urinary bladder. <h3>Comment</h3> Distention of the urinary bladder
Juxtaglomerular Cell Changes in Dogs with Antirenin Titers
Authors: Herman E. Schmid, Leonard A. Graham
Journal: Circulation Research (1962)

Renin concentration and juxtaglomerular cell changes, as demonstrated by the Bowie and periodic acid stains, were studied in 11 dogs with partial renal artery constrictions of 1 to 70 months' duration. Three received injections of saline, had renal renin contents averaging 2 Goldblatt Dog Units per Gm. kidney tissue, and had juxtaglomerular cell ratings averaging 1.5, as evaluated on a plus 1 to plus 5 basis. Eight dogs injected with hog renin developed antirenin titers ranging from 1 to 83 units per cc. plasma, had an increase in renal renin content ranging from 3 to 22 Dog Units, and had a juxtaglomerular cell rating ranging from 1.7 to 4.0. The juxtaglomerular cells in the highrenin specimens were markedly hypertrophied and densely packed with cytoplasmic granules. Also, juxtaglomerular cells with granules were found associated with both the afferent and efferent vessels at the vascular pole of the glomerulus. This study supports the concept that the juxtaglomerular cell is the site of renin formation.
Abstract 1139: Novel, cellular active inhibitors of G6PD, a key mediator of ROS-induced cellular stress
Authors: Allan M. Jordan, Niall M. Hamilton, Nicola S. Hamilton, James R. Hitchin, Dominic I. James, Stuart D. Jones, Amanda J. Lyons, H. Nikki March, Graeme J. Thomson, Ian D. Waddell, Donald J. Ogilvie
Journal: Cancer Research (2012)

Abstract Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme in the pentose phosphate pathway (PPP) and catalyses the oxidation of glucose-6-phosphate to glucono-δ-lactone-6-phosphate with the concomitant production of NADPH. Alongside an important role in the production of biosynthetic precursors such as ribonucleotides, this pathway is a major cellular source of NADPH. As such, the pathway plays a critical role in both the biosynthesis of fatty acids &amp; cholesterol biosynthesis (thus supporting cell division) and maintaining glutathione in its reduced state (GSH), the latter ameliorating cellular stress arising from reactive oxygen species (ROS). Given these key roles, modulation of the pathway has potential therapeutic application, and inhibition of G6PD is an attractive target, particularly in combination with standard of care radiotherapy or cytotoxic drugs which can increase ROS. We have developed a series of novel steroid G6PD inhibitors which, in our hands, modulate flux through the PPP and increase ROS-induced stress in cells. This disclosure will describe some of our results in this area. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1139. doi:1538-7445.AM2012-1139
The Relevance of Glucose Counterregulatory Systems to Patients with Insulin-Dependent Diabetes Mellitus*
Authors: PHILIP E. CRYER, NEIL H. WHITE, JULIO V. SANTIAGO
Journal: Endocrine Reviews (1986)

THE CENTRAL nervous system (CNS) can neither synthesize nor store glucose, its predominant metabolic fuel. Thus, it is dependent upon a continuous supply of glucose from the circulation. Hypoglycemia can cause profound dysfunction of the brain, even brain death. The fact that hypoglycemia is an uncommon clinical event, except in persons who use drugs that lower the plasma glucose concentration, is testimony to the efficacy of the physiological mechanisms that normally prevent or correct hypoglycemia. Glucoregulation is normally the result of the glucoselowering actions of insulin and the glucose-raising actions of glucose-counterregulatory factors (1, 2). It has long been recognized that deficient insulin secretion is the fundamental abnormality in patients with insulindependent diabetes mellitus (IDDM). The contribution of counterregulatory systems to glycemic excursions ranging from hypoglycemia to hyperglycemia, in the context of imperfect insulin replacement, has been documented more recently in patients with IDDM and is the subject of this review.
Catastrophic cat care
Authors: G. Dunea
Journal: BMJ (1998)

Have you ever had a sick cat? If you have, and even if your cat is American born, you will find there is no cradle to grave MediCAT programme to pay for things like CAT-scans, not even a MediPET scheme to reimburse financially strapped owners of emotionally disturbed pets who need a multicolour PET-scan.



Imagine then the crisis on Chicago's gold coast when a much petted Siamese cat, having already survived the worst bear market in South East Asia's history, developed a red eye. The primary care veterinarian prescribed eye drops; but the cat owner, untrammelled by managed care gatekeepers, decided to seek a second opinion from a highly regarded specialist, who dealt exclusively …
Social and Emotional Adaptations of Children with Transplanted Kidneys and Chronic Hemodialysis
Authors: AMAN U. KHAN, CHARLES H. HERNDON, SEYED Y. AHMADIAN
Journal: American Journal of Psychiatry (1971)

Fourteen children were studied for social adjustment, emotional status, level of intelligence, and self-concept; five had transplanted kidneys that had been functioning well for periods of two to five years, two others had unsuccessful transplants, and the remaining seven had been on hemodialysis from six months to several years. Results indicated that most of the children had serious social and emotional difficulties. Feelings of social isolation, excessive dependency upon the parents, and depression were common. The authors point out the sources of social and emotional difficulties and make suggestions for avoiding some of them.
S76 Tb Infection In The Nepali Population In South-east London Displays Different Characteristics Compared To The Tb Population In Nepal
Authors: N. Dearnley, R. Eyres, T. Simpson, E. Stephenson, M. Belton, P. Palchaudhuri
Journal: Thorax (2014)

Introduction  The World Health Organisation classifies Nepal as having high Tuberculosis (TB) burden (Estimated incidence 163/100,000). TB within the Nepali population in the UK has not been formally characterised but a recent study indicates unique characteristics compared to overall UK data. 1  These include higher rates of multi-drug resistant (MDR) TB (4.7% vs 1.6%), and lower rates of TB/HIV co-infection (1.1% vs 8%). We sought to investigate if these differences were also found in the TB population in Nepal or were unique to the immigrant population in SE London.  Methods  Retrospective cohort analysis was performed of all Nepali TB patients in Greenwich between 2007–2012. Data collected included site, drug resistance, HIV co-infection and completion rates. Results were compared to Nepal National Tuberculosis Programme (NTP) data from 2012. Data analysis was conducted as part of an Internship with the Britain Nepal Medical Trust.  Results  86 UK patient records were analysed and compared to NTP 2012 data (n = 34,245). TB patients in Greenwich were younger than patients in Nepal; 91.8% age   Of the patients diagnosed with pulmonary TB in Greenwich, only 19.7% had sputum smear positive disease, compared to 68% in Nepal. UK patients had higher rates of extrapulmonary disease compared to Nepal (41% vs. 23.8%).  The rate of MDR TB in new diagnoses shows a marked difference; Greenwich having rates of 4.7% compared to 2.2% in Nepal. Despite the higher rates, risk factors for MDR TB were low in UK immigrants (HIV 1.1%, previous TB treatment 0% and MDR TB contact 0%).  Treatment completion in Greenwich was 98% compared with 91% in Nepal, who run a national DOTS programme.  Conclusion  Nepali expatriate TB patients display different characteristics to both UK and Nepal TB populations, and have high rates of MDR TB which cannot be accounted for by increased risk factors. Further studies are required to identify if this reflect differences in TB diagnostics or relate to the migration status of the Nepali patients.  References  T Simpson, E Stephenson, P Palchaudhuri. A study of tuberculosis in an expatriate Nepalese community in South-East London. poster presentation.  European Respiratory Society
Serial Ga-67 Scintigraphic Findings of Adult Onset Stillʼs Disease
Authors: Akira Fujikawa, Hiroshi Hosoai, Taiji Tamura, Yutaka Naoi
Journal: Clinical Nuclear Medicine (2004)

Adult-onset Still's disease (AOSD) is a cause of fever unknown origin. The clinical manifestations of AOSD include a high spiking fever, evanescent maculopapular rash, polyarthralgias associated with leukocytosis, and abnormal liver tests. We present serial Ga-67 scintigraphic findings in a young male with persistent remittent fever and the final diagnosis of AOSD. Repeated Ga-67 scintigraphic studies demonstrated diffusely increased activity in the bone marrow, hepatosplenomegaly, and pericarditis in proportion to the severity of the disease. Awareness of the Ga-67 scintigraphic imaging findings of AOSD could help narrow the differential diagnosis among the long list in fever of unknown origin.
In the Clinic: Where Paclitaxel and Docetaxel Stand
Authors: C. McNeil
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article In the Clinic: Where Paclitaxel and Docetaxel Stand Get access Caroline McNeil Caroline McNeil Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 15, 2 August 1995, Page 1107, https://doi.org/10.1093/jnci/87.15.1107 Published: 02 August 1995
Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients
Authors: Mette Krag, Anders Perner, Jørn Wetterslev, Matt P. Wise, Mark Borthwick, Stepani Bendel, Colin McArthur, Deborah Cook, Niklas Nielsen, Paolo Pelosi, Frederik Keus, Anne Berit Guttormsen, Alma D. Moller, Morten Hylander Møller
Journal: Intensive Care Medicine (2015)
Saw palmetto extract is not effective for benign prostatic hyperplasia
Authors: David Spurgeon
Journal: BMJ (2006)

Saw palmetto extract is not effective for BPH 20, 100Saw palmetto, a herbal extract taken by more than two million US men for relief from the symptoms of benign prostatic hyperplasia (BPH), showed no benefit over placebo, a study has found.The year long, double blind, randomised trial was reported this week in the New England Journal of Medicine (2006;354:557-66).The herbal extract, taken from the berries of a small, palm-like north American plant, is commonly recommended as an alternative to prescription drugs.An accompanying editorial says additional rigorous, placebo controlled studies are needed before conclusions can be made about the long term effectiveness and safety of other saw palmetto preparations and that herbal remedies should be subjected to clinical trials of the same quality needed for approval of standard drugs.Until this is done, it says, doctors are responsible for protecting patients from the risks of unproved therapies.