tbuckley/cabot-search huggingface dataset:
Transient ischaemia induced by rapid cardiac pacing results in myocardial preconditioning
Authors: A. Vegh, L. Szekeres, J. R Parratt
Journal: Cardiovascular Research (1991)

Journal Article Transient ischaemia induced by rapid cardiac pacing results in myocardial preconditioning Get access Agnes Vegh, Agnes Vegh Correspondence to: Professor Parratt Search for other works by this author on: Oxford Academic PubMed Google Scholar Laszlo Szekeres, Laszlo Szekeres Search for other works by this author on: Oxford Academic PubMed Google Scholar James R Parratt James R Parratt Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 25, Issue 12, December 1991, Pages 1051–1053, https://doi.org/10.1093/cvr/25.12.1051 Published: 01 December 1991 Article history Received: 05 September 1991 Accepted: 14 October 1991 Published: 01 December 1991
Hepatitis B Virus Transmission in an Elementary School Setting
Authors: Ian Williams
Journal: JAMA (1997)

The risk of transmission of hepatitis B virus (HBV) in day care centers and schools is low.To investigate the source of HBV transmission for an elementary school teacher with acute hepatitis B.Serologic survey for HBV infection among elementary school students, school staff, and household members of an HBV-infected teacher and student.General community and elementary school.Elementary school students and staff members and household members of an HBV-infected teacher.Elementary school students, school staff, and household members of an HBV-infected teacher were tested for markers of HBV infection. Samples positive for hepatitis B surface antigen (HBsAg) were tested for HBsAg subtype using monoclonal antibodies and examined for HBV DNA homology by polymerase chain reaction techniques.An HBV-infected student and the teacher were found to have the same HBV subtype (ayw1-2) and to have identical HBV DNA sequences. The teacher reported none of the usual risk factors for acquiring HBV infection, and none of her family members had been infected prior to her illness. The specific means of HBV transmission from student to teacher was not identified. Of 108 total children in the same grade as the HBV-infected student, 102 (94%) were tested for serologic markers of HBV infection, and none was positive.This investigation documented transmission from an HBV-infected student to a teacher in an elementary school setting without a reported overt percutaneous or permucosal exposure to blood or infectious body fluids. Transmission of HBV to other students or staff members in the school was not observed.
Clinical investigation of the novel iron-chelating agent, CP94, to enhance topical photodynamic therapy of nodular basal cell carcinoma
Authors: S.M. Campbell, C.A. Morton, R. Alyahya, S. Horton, A. Pye, A. Curnow
Journal: British Journal of Dermatology (2008)

Photodynamic therapy (PDT) involves the activation of a photosensitizer by visible light to produce activated oxygen species within target cells, resulting in their destruction. Evidence-based guidelines support the efficacy of PDT using topical 5-aminolaevulinic acid (ALA-PDT) in actinic keratoses, Bowen disease and basal cell carcinoma (BCC). Efficacy for nodular BCC appears inferior to that for superficial BCC unless prior debulking or repeat treatments are performed. Objectives The aim of this study was to assess the safety and efficacy of adding a novel iron-chelating agent, CP94 (1,2-diethyl-3-hydroxypyridin-4-one hydrochloride), to topical ALA, to temporarily increase the accumulation of the photosensitizer in the tumour.A mixed topical formulation of ALA + increasing concentrations of CP94 was used to carry out PDT on previously biopsied nodular BCC with no prior lesion preparation using standard light delivery. The area was assessed clinically and surgically excised 6 weeks later for histological examination.Enhanced PDT using 40% CP94 resulted in significantly greater clearance rates in nodular BCC than with ALA-PDT alone, in our protocol of single-treatment PDT with no lesion preparation.The results of this study demonstrate the safe and effective use of an enhanced ALA-PDT protocol for nodular BCC using CP94, with no adverse reactions to this modification. This is the first time this formulation has been used in patients. This formulation is now the focus of further study.
ATHEROMA OF CORONARY ARTERY AND MYOCARDIAL FIBROSIS
Authors: J. Grant, J. H. Miller
Journal: BMJ (1935)

FIBROSIS [TimBRITtsx 353 intercostal neuralgia, which was subsiding.Otherwise he was fit, with an occasional morning expectoration of about half an ounce.Case 3.-A girl, aged 14, was referred by Professor Tylecote.She had long-standing cough and sputum, which was not offensive.Soveral weeks' postural drainage failed to diminislh the amount of 'che expectoration, which was from three to four ounces daily.Lipiodol demonstrated well-marked tubular bronchiectasis in a collapsed left lower lobe.Her recovery after lobectomy was uneventful, and she did not develop a bronchial fistula.Case 4.-This patient was sent to me by Mr. Burt Hamilton, under whose care she had been for several months.After regular postural drainage and occasional bronchoscopic aspira- tion her sputum had diminished to vanishing-point, and her general condition was so good that on her transfer to one of my beds I sent her home.Vithin a week she returned ,, ,,, .;..., FIGf5with the typical foul expectoration and asking for operati..o | g ' . .
Selective Progesterone Receptor Modulator Development and Use in the Treatment of Leiomyomata and Endometriosis
Authors: Kristof Chwalisz, Maria Claudia Perez, Deborah DeManno, Craig Winkel, Gerd Schubert, Walter Elger
Journal: Endocrine Reviews (2005)

Selective progesterone receptor modulators (SPRMs) represent a new class of progesterone receptor ligands. SPRMs exert clinically relevant tissue-selective progesterone agonist, antagonist, or mixed agonist/antagonist effects on various progesterone target tissues in vivo. Asoprisnil (J867) is the first SPRM to reach an advanced stage of clinical development for the treatment of symptomatic uterine fibroids and endometriosis. Asoprisnil belongs to the class of 11β-benzaldoxime-substituted estratrienes that exhibit partial progesterone agonist/antagonist effects with high progesterone receptor specificity in animals and humans. Asoprisnil has no antiglucocorticoid activity in humans at therapeutic doses. It exhibits endometrial antiproliferative effects on the endometrium and breast in primates. Unlike progesterone antagonists, asoprisnil does not induce labor in relevant models of pregnancy and parturition. It induces amenorrhea primarily by targeting the endometrium. In human subjects with uterine fibroids, asoprisnil suppressed both the duration and intensity of uterine bleeding in a dose-dependent manner and reduced tumor volume in the absence of estrogen deprivation. In subjects with endometriosis, asoprisnil was effective in reducing nonmenstrual pain and dysmenorrhea. Asoprisnil may, therefore, provide a novel, tissue-selective approach to control endometriosis-related pain. SPRMs have the potential to become a novel treatment of uterine fibroids and endometriosis.
Application of log-linear model in inference on karyotypic evolution in chronic myelocytic leukemia.
Authors: T Hashimoto, M Ohtaki, N Kamada, H Yamamoto, M Munaka
Journal: Environmental Health Perspectives (1990)

Relationships among additional chromosome abnormalities in chronic myelocytic leukemia (CML) with translocation 9;22 [Philadelphia chromosome (Ph1)-positive CML] were analyzed by log-linear models on 709 karyotypes reported in the literature. Additional abnormalities, such as the gain of chromosome 8 (+8), gain of Philadelphia chromosome (+Ph1), isochromosome of the long arm (q) of chromosome 17 [i(17q)], and the gain of chromosome 19 (+19), were frequently observed. A four-way 2 x 2 x 2 x 2 contingency table was considered with respect to the appearance of these four abnormalities, then the hierarchical log-linear models having at least four main effects were fitted to the observed contingency table. Akaike's information criteria of the models reflected the fitness of the model very well. Parameter estimates of the interaction terms indicated that the combinations of two abnormalities, '+8 and +19', '+Ph1 and +19', and '+8 and i(17q)' were positively associated, while '+Ph1 and i(17q)', and '+19 and i(17q)' were negatively associated. Based on the results of the data analysis, an inference was made on the route of karyotypic evolution in Ph1-positive CML; it statistically supports the hypothesis presented by Heim and Mitelman.
Charles Anthony Rushmer
Authors: P. Millard
Journal: BMJ (2002)

Former general practitioner Upwell, Wisbech (b 1927; q St Mary's Hospital, London, 1954), died from oesophageal cancer on 18 July 2002.

Tony did national service in the navy before studying medicine. After house jobs in Paddington and Preston, he worked in Walsham and Gillingham, before moving to Upwell in 1962. In his practice Tony was quiet, careful, precise, intellectual, and rigorous. As senior partner he was supportive of any efforts that we made to extend our services. Decisions were made democratically and we were all able to contribute under his stewardship. Tony was a great gardener. Anyone who had the pleasure of visiting his garden would recall the impact of the tranquil place that Tony and his wife, Eileen, created.
764 ENTECAVIR EFFECTIVENESS IN DAILY CLINICAL PRACTICE, INTERIM ANALYSIS OF THE ITALIAN Master-Entas COHORT STUDY OF PATIENTS WITH CHRONIC HEPATITIS B
Authors: T. Giuberti, M. Fasano, G. Brancaccio, T. Santantonio, A. Grasso, A. Marzano, F. Bronte, S. Maimone, S. Fagiuoli, N. Caporaso, E. Petrelli, G. Svegliati Baroni, G. Labbadia, G. Verucchi, G.A. Niro, G.B. Pinzello, A. Montineri, F. Vinelli, M. Massari, L. Nosotti, A. Picardi, G. Missale
Journal: Journal of Hepatology (2013)
TCT-3 A randomized comparison of drug-eluting vs. bare metal stenting in patients with non-ST elevation myocardial infarction. Results of the ELISA-3 angiographic substudy
Authors: Wouter Remkes, Erik A. Badings, Jan-Henk E. Dambrink, Petra C. Koopmans, Salem H. The, Harry Suryapranata, Arnoud van 't Hof
Journal: Journal of the American College of Cardiology (2014)
How druggable is protein kinase CK2?
Authors: Giorgio Cozza, Andrea Bortolato, Stefano Moro
Journal: Medicinal Research Reviews (2009)

CK2 is a pleiotropic, ubiquitous, and constitutively active protein kinase (PK), with both cytosolic and nuclear localization in most mammalian cells. The holoenzyme is generally composed of two catalytic (α and/or α′) and two regulatory (β) subunits, but the free α/α′ subunits are catalytically active by themselves and can be present in cells under some circumstances. CK2 catalyzes the phosphorylation of more than 300 substrates characterized by multiple acidic residues surrounding the phosphor-acceptor amino acid, and, consequently, it plays a key role in several physiological and pathological processes. But how can one kinase orchestrate all these tasks faithfully? How is it possible that one kinase can, despite all pleiotropic characteristics of PKs in general, be involved in so many different biochemical events? Is CK2 a druggable target? Several questions are still to be clearly answered, and this review is an occasion for a fruitful discussion. © 2009 Wiley Periodicals, Inc. Med Res Rev, 30, No. 3, 419–462, 2010
Author’s reply to Dr Kadayifci
Authors: E. Williams
Journal: Endoscopy (2008)

Dr. Kadayifci raises two interesting points. Firstly, as he correctly points out, wire-guided cannulation has been reported to reduce the risk of post-ERCP pancreatitis (PEP). As authors, we were interested in this aspect of practice and its influence on outcome. However at the design stage of the study it became apparent that inclusion of every variable of interest would result in a questionnaire of prohibitive length and an analysis that would be ”overfitted”. As a result, endoscopists were not asked to list all the devices used to attempt cannulation, and although acquisition of a cholangiogram was the norm, we are not able to quantify how many cannulations were initially performed with a wire rather than a catheter. We agree with Dr Kadayifci that this is an area of practice that merits further examination.
Management of Critically Ill Patients—Reply
Authors: Matthijs Kox, Peter Pickkers
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Preparing the BMJ for the electronic revolution
Authors: J. Smith, R. Smith
Journal: BMJ (1996)

Healthcare workers who receive injuries need to have confidence that by immediately reporting the injury they will receive appropriate advice and treatment, as well as the support and encouragement to continue in practice if possible.As with any immunocompromised healthcare worker, they will be at greater risk than their patients, and strict adherence to precautions to control infection risk is essential for their own safety.In some states in America such as New York and Michigan, guidelines state that "limiting the practice of HIV infected healthcare workers is inappropriate given the extremely low risk of HIV transmission from healthcare worker to patient as well as the negative consequences of practice restrictions."" 1 The health professions need to use current knowledge to support those who have become infected.In allaying public fears, the rights of healthcare workers have been subsumed for too long.
Griseofulvin in Treatment of Persistent Fungal Infections of the Skin
Authors: A. J. E. Barlow, F. W. Chattaway, G. K. Hargreaves, C. J. La Touche
Journal: BMJ (1959)

The recent discovery that griseofulvin can be used orally as a fungistatic, effective against the dermatophytes, represents a major advance in therapy. In this country the majority of cases of ringworm are due to infection of the feet by organisms which can be controlled by topical fungicides, albeit with a high relapse rate. In recent years, however, there has been an increased incidence of infection by Trichophyton rubrum, a species which gives rise to resistant and intractable infections, especially when the nails are infected, and there would appear to be a small group of people in whom infection of multiple nails by this organism has hitherto been incurable. The preliminary papers of Williams, Marten, and Sarkany (1958) and Blank and Roth (1959) have shown that this organism, like the other dermatophytes, is inhibited in vivo by griseofulvin, and there would appear to be every likelihood that these infections may soon be controllable. Clinical experience of the drug is as yet too limited for a great deal to be known about the effective dosage, the duration of treatment required, the long-term results, and the possibility of toxic reactions. The following report records the experience of two independent groups of observers who have handled the drug during the last seven months. Of the 34 patients treated, 26 have had long-standing infection of multiple nails and skin by T. rubrum, previously resistant to numerous lines of treatment, including surgical avulsion of nails. In each case fungus has been demonstrated microscopically in the affected site and identified by culture prior to starting treatment. All patients have been examined and scrapings checked at regular intervals, and in 12 instances blood counts have been done daily for 14 days and thereafter at weekly intervals. In the following report an area is said to have cleared only when the clinical state has returned to normal and fungus can no longer be demonstrated microscopically or by culture ; in most instances photographs have been taken to compare changes in nail infection ; except in the group specified, no local treatment has been carried out.
Twenty-year follow-up of the breast cancers diagnosed during the Breast Cancer Detection Demonstration Project
Authors: C. R. Smart, C. Byrne, R. A. Smith, L. Garfinkel, A. H. Letton, G. D. Dodd, O. H. Beahrs
Journal: CA A Cancer Journal for Clinicians (1997)

This study reports on the 20-year follow-up of the women diagnosed with breast cancer in the Breast Cancer Detection Demonstration Project (BCDDP) between 1973 and 1980. This project provided 5 years of screening with physical examination and two-view mammography for 280,000 volunteer women across the United States. Based on a 96% follow-up from 1993 to 1995 of the 4,051 women with breast cancer available for analysis, 2,658 (66%) were alive and 1,393 (34%) were dead. A high proportion of the cancers were detected by mammography alone, and 28.6% of all the cancers were smaller than 1.0 cm. Survival rates were calculated by life table method with deaths from breast cancer as the outcome. The adjusted survival rate for the entire group was 80.5%, and the observed survival rate was 61.7%. Adjusted and observed survival rates were 97.2% and 78.5%, respectively, for women with non-invasive cancers and 78.2% and 59.3%, respectively, for those with invasive cancers. Lymph node status and the size of the cancer at diagnosis were prognostic indicators of survival in the BCDDP Women with invasive cancers and negative lymph nodes had an 85.5% breast cancer survival rate and a 65.6% observed survival rate. Adjusted survival rates for women with invasive breast cancers were 90.2% for cancers smaller than 1 cm, 80.5%, for cancers 1.0 to 1.9 cm, 70.5% for cancers 2.0 to 4.9 cm, and 60.6% for cancers larger than 5 cm. Women 40 to 49 years of age demonstrated a greater survival with noninvasive or invasive cancers smaller than 5.0 cm compared with women 50 to 59 and 60 to 69 years of age at diagnosis. These results from the BCDDP are discussed in the context of the recent decline in breast cancer incidence and mortality in the United States.
Spelling of Münchhausen
Authors: Frederick C. Blodi
Journal: JAMA (1983)

To the Editor.—  Although it is a small detail, the repeated misspelling ofMunchhausen(eg, 1982;248:3008) is somewhat irritating.  Baron Munchhausen is a famous figure in German literature. His name obviously consists of two names. (As is so frequently the case in German, you can put nouns next to each other and make a new noun.) The first part of the name isMunchand ends with ach, which is practically an independent letter of the alphabet (similar to the Greekchi). The second part of the name ishausen, obviously derived fromHaus, ie, a house. The name is related toMunchen(Munich). To drop anhmakes not only an awkward word, but also reminds one of Eliza inMy Fair Lady.
Acute Suprarenal Failure
Authors: J. Smart
Journal: BMJ (1954)

Clinical Course.-Deterioration was rapid; the patient developed purpura, haemoptysis, and epistaxis, and died on March 19.Necropsy Findings.-Theright lung weighed 1,010 g.The bronchus to the right middle lobe was occluded by a mass of whitish growth 3 by 2 cm. in diameter.The remainder of the right lung and the left lung were not involved in growth.The liver weighed 5 kg.and showed widespread secondary deposits, as did the pancreas.Microscopy of primary and secondary tumours showed an oat-celled carcinoma.Section of the sternum revealed metastatic carcinoma.
Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors.
Authors: D Salvemini, P T Manning, B S Zweifel, K Seibert, J Connor, M G Currie, P Needleman, J L Masferrer
Journal: Journal of Clinical Investigation (1995)

We have recently put forward the hypothesis that the dual inhibition of proinflammatory nitric oxide (NO) and prostaglandins (PG) may contribute to the antiinflammatory properties of nitric oxide synthase (NOS) inhibitors. This hypothesis was tested in the present study. A rapid inflammatory response characterized by edema, high levels of nitrites (NO2-, a breakdown product of NO), PG, and cellular infiltration into a fluid exudate was induced by the administration of carrageenan into the subcutaneous rat air pouch. The time course of the induction of inducible nitric oxide synthase (iNOS) protein in the pouch tissue was found to coincide with the production of NO2-. Dexamethasone inhibited both iNOS protein expression and NO2- synthesis in the fluid exudate (IC50 = 0.16 mg/kg). Oral administration of N-iminoethyl-L-lysine (L-NIL) or NG-nitro-L-arginine methyl ester (NO2Arg) not only blocked nitrite accumulation in the pouch fluid in a dose-dependent fashion but also attenuated the elevated release of PG. Finally, carrageenan administration produced a time-dependent increase in cellular infiltration into the pouch exudate that was inhibited by dexamethasone and NOS inhibitors. At early times, i.e., 6 h, the cellular infiltrate is composed primarily of neutrophils (98%). Pretreatment with colchicine reduced both neutrophil infiltration and leukotriene B4 accumulation in the air pouch by 98% but did not affect either NO2- or PG levels. In conclusion, the major findings of this paper are that (a) selective inhibitors of iNOS are clearly antiinflammatory agents by inhibiting not only NO but also PG and cellular infiltration and (b) that neutrophils are not responsible for high levels of NO and PG produced.
Scientists Probe the Role of Clinicians in Rising Rates of Late Preterm Birth
Authors: Bridget M. Kuehn
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Review: Pharmacist care improves therapeutic and safety outcomes in older adults
Authors: William J. Hall
Journal: Annals of Internal Medicine (2013)

Source Citation Lee JK, Slack MK, Martin J, Ehrman C, Chisholm-Burns M. Geriatric patient care by US pharmacists in healthcare teams: systematic review and meta-analyses. J Am Geriatr Soc. 2013;61:1119-27. 23796001