Postmenopausal Hormones and Glycemic Effects
Authors: Alka M. Kanaya, David Herrington, Elizabeth Barrett-Connor
Journal: Annals of Internal Medicine (2003)

Letters16 December 2003Postmenopausal Hormones and Glycemic EffectsAlka M. Kanaya, MD, David Herrington, MD, and Elizabeth Barrett-Connor, MDAlka M. Kanaya, MDFrom University of California, San Francisco, San Francisco, CA 94143-1732; Wake Forest University School of Medicine, Winston-Salem, NC 27157-1066; and University of California, San Diego, La Jolla, CA 92093-0607.Search for more papers by this author, David Herrington, MDFrom University of California, San Francisco, San Francisco, CA 94143-1732; Wake Forest University School of Medicine, Winston-Salem, NC 27157-1066; and University of California, San Diego, La Jolla, CA 92093-0607.Search for more papers by this author, and Elizabeth Barrett-Connor, MDFrom University of California, San Francisco, San Francisco, CA 94143-1732; Wake Forest University School of Medicine, Winston-Salem, NC 27157-1066; and University of California, San Diego, La Jolla, CA 92093-0607.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-12-200312160-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Drs. Sheffield and Larson ask whether differences in the level of physical activity over time between women assigned to hormone therapy and those assigned to placebo may have explained the reduction in incident diabetes we observed among women taking hormones in the Heart and Estrogen/progestin Replacement Study (HERS). Participants in HERS self-reported physical activity at each annual visit. However, addition of physical activity as a time-dependent covariate in our model did not alter the risk for incident diabetes (relative hazard, 0.65 [95% CI, 0.47 to 0.89]).Drs. Girod and Brotman suggest that hormone therapy may have produced favorable ...References1. Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. The Writing Group for the PEPI Trial. JAMA. 1995; 273:199-208. [PMID: 7807658] Google Scholar2. Consequences of the new diagnostic criteria for diabetes in older men and women. DECODE Study (Diabetes Epidemiology: Collaborative Analysis of Diagnostic Criteria in Europe). Diabetes Care. 1999; 22:1667-71. [PMID: 10526732] Google Scholar3. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, . Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized, controlled trial. JAMA. 2002;288:321-33. [PMID: 12117397] CrossrefMedlineGoogle Scholar4. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, . Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA. 1998;280:605-13. [PMID: 9718051] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Alka M. Kanaya, MD; David Herrington, MD; Elizabeth Barrett-Connor, MDAffiliations: From University of California, San Francisco, San Francisco, CA 94143-1732; Wake Forest University School of Medicine, Winston-Salem, NC 27157-1066; and University of California, San Diego, La Jolla, CA 92093-0607. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoGlycemic Effects of Postmenopausal Hormone Therapy: The Heart and Estrogen/progestin Replacement Study: A Randomized, Double-Blind, Placebo-Controlled Trial Alka M. Kanaya , David Herrington , Eric Vittinghoff , Feng Lin , Deborah Grady , Vera Bittner , Jane A. Cauley , and Elizabeth Barrett-Connor Postmenopausal Hormones and Glycemic Effects John V.L. Sheffield and Eric B. Larson Postmenopausal Hormones and Glycemic Effects John P. Girod and Daniel J. Brotman Postmenopausal Hormones and Glycemic Effects Aidan McElduff Metrics 16 December 2003Volume 139, Issue 12Page: 1044KeywordsAdipose tissueEstrogen replacement therapyExerciseGlucoseGlucose tolerance testsHeartHormonal therapyHormone replacement therapyHormonesLongitudinal studies ePublished: 16 December 2003 Issue Published: 16 December 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...