tbuckley/cabot-search huggingface dataset:
Immunologic Differences Between Psoriatic and Rheumatoid Arthritis.
Authors: Joseph L. Hollander
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Immunologic Differences Between Psoriatic and Rheumatoid Arthritis.Joseph L. Hollander, M.D., F.A.C.P., Arnold J. Rawson, M.D., Francisco J. Tapanes, M.D.Joseph L. Hollander, M.D., F.A.C.P.Search for more papers by this author, Arnold J. Rawson, M.D.Search for more papers by this author, Francisco J. Tapanes, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-881_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical similarities and differences between rheumatoid and psoriatic arthritis are well known. Patients with psoriatic arthritis are seronegative for rheumatoid factor, but so also are one fifth of those with classical rheumatoid arthritis and nearly all those with juvenile rheumatoid arthritis when the usual latex or sheep-cell tests are used. Using the newer methods for quantifying antigammaglobulins by immunoadsorption to cross-linked IgG, elution with acid buffer, and radial immunodiffusion, it has been shown that almost all sera and joint fluids from active but seronegative juvenile or adult rheumatoids exhibit significantly elevated amounts of anti-immunoglobulin, mainly of IgG type.Sera... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1972Volume 76, Issue 5Page: 881-881KeywordsLatexPsoriatic arthritisRheumatoid arthritis ePublished: 1 December 2008 Issue Published: 1 May 1972 PDF downloadLoading ...
Tienilic acid: a single treatment for hyperuricaemia and hypertension?
Authors: T Gibson, V A Rodgers, C F Potter, H A Simmonds
Journal: Annals of the Rheumatic Diseases (1980)

Tienilic acid is a drug with established uricosuric and hypotensive properties. We have examined its potential role as a single treatment for hyperuricaemia and hypertension, 2 disorders which are commonly associated. In 17 subjects with gout, blood uric acid levels were reduced by approximately 50%. Eleven of these patients also had hypertension which was improved by tienilic acid. However, a statistically significant effect was observed only with standing diastolic blood pressure. Side effects included acute episodes of gout in 4 patients and transient loin pain and dysuria in 1 patient. The precipitation of gouty arthritis is an acknowledged risk of all potent hypouricaemic drugs. The hazard of urate deposition in the renal tract implicit in the history of loin pain is a more serious complication. Thus, it would appear that tienilic acid is a potentially valuable drug which may have a special role in patients with hyperuricaemia and hypertension. Further study is necessary to determine how it may be best administered without the risk of renal damage.
Transvestism and Transsexualism
Authors: Harry Benjamin
Journal: JAMA (1967)

<h3>To the Editor:—</h3> I have seen and examined more than 300 transvestites and transsexuals during the past 14 years, and am at present engaged in active research on this problem with a number of collaborators, under a grant from the Erickson Educational Foundation. I have just published the first medical book on the subject,<i>The Transsexual Phenomenon</i>(Julian Press, New York). Dr. Hastings has given a clear and comprehensive summary, especially as to the management of transsexualism (<b>197</b>:599, 1966). Dr. Barker is right in differentiating transvestism from transsexualism (<b>198</b>:488, 1966), but he did not emphasize the fact that transvestism can be merely a symptom of transsexualism, which is a psychopathological condition, based on a disturbance of gender role orientation. According to recent animal experiments by Seymour Levine and Roger Gorski, transsexualism may indeed have a neuro-endocrine, prenatal origin, with transvestism as its most frequent symptom in later life.
Relative Efficiency of Finger-Cot Specimens and Stool Examinations in Screening for Schistosoma Mansoni and Other Parasitic Infections
Authors: Walter Futterweit, Howard B. Shookhoff
Journal: New England Journal of Medicine (1960)

IT is estimated that the Puerto Rican population of New York City is between 500,000 and 750,000. The prevalence of Schistosoma mansoni infections in this group is known to be approximately 10 per cent.1 , 2 There are therefore 50,000 to 75,000 persons with schistosomiasis, in many of whom prompt diagnosis and early treatment would prevent the later, potentially fatal, complications. The most frequent of these is portal hypertension due to periportal fibrosis. Less frequent but just as serious is the development of severe parenchymal and arterial lesions in the lungs, with resultant pulmonary hypertension.One of the functions of the Tropical . . .
Principles and Practice of Mechanical Ventilation
Authors: Lindell K. Weaver
Journal: JAMA (1994)

<i>Principles and Practice of Mechanical Ventilation</i>, edited by Martin J. Tobin, MD, is an outstanding text, unique and surprisingly up to date. Even with 76 contributing authors, the text maintains cohesion and reads well. It should be examined by pulmonologists, intensivists, anesthesiologists, and respiratory care practitioners, although anyone interested in the subject of mechanical ventilation should find it informative and helpful. I especially liked the sections dealing with the historical basis of mechanical ventilation, the work of breathing, and ethical problems associated with mechanical ventilation. The book is very comprehensive. Virtually all aspects are covered, along with provocative thoughts on possible future modes, such as closed-loop mechanical ventilation. The "inner workings" of ventilators are discussed. The performances of those currently available are compared for various modes of ventilatory support. Tables and figures are thoughtful and descriptive. The text is indexed well. In conclusion,<i>Principles and Practice of Mechanical Ventilation</i>is
Lavage Administration of Dilute Surfactants after Acute Lung Injury in Neonatal Piglets
Authors: VENKATARAMAN BALARAMAN, JOAN MEISTER, TERCIA L. KU, SNEHA L. SOOD, ELIZABETH TAM, JEFFREY KILLEEN, CATHERINE F. T. UYEHARA, EDMUND EGAN, DAVID EASA
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Exogenous surfactant therapy is not standard in the acute respiratory distress syndrome (ARDS) because of a lack of proven benefit. Nonuniform surfactant distribution after either bolus or aerosol administration may be an important factor limiting response. In a previous study of acute lung injury, we demonstrated that lavage administration of Exosurf (13.5 mg phospholipid/ml) was both effective and distributed uniformly in the lungs. Since the endogenous surfactant pool is much smaller than the typical dose of exogenous surfactant administered, we hypothesized that dilute surfactant preparations (4–4.5 mg phospholipid/ml) administered by lung lavage would be equally effective in reversing pulmonary dysfunction in a piglet model of acute lung injury. We compared three dilute surfactants: Infasurf (n = 5), KL4-Surfactant (n = 6), and Exosurf (n = 5) with controls (n = 6) and undiluted Exosurf (13.5 mg phospholipid/ml; n = 6). All dilute surfactant preparations were effective in improving oxygenation and other parameters of pulmonary function. Surfactant administered by lavage resulted in uniform lung distribution. We conclude that dilute surfactants administered by lung lavage are effective in reversing pulmonary dysfunction after acute lung injury. We speculate that doses in the range of 20–40 mg phospholipid/kg may be adequate to improve lung function in ARDS when exogenously administered surfactant is uniformly distributed in the lung.
Ian Ross Russell
Authors: Rob Ross Russell
Journal: BMJ (2006)

Former general practitioner Bishop's Stortford, Hertfordshire (b 1930; q Cambridge/St Thomas' Hospital, London, 1954; MRCGP, DObst RCOG), died from cholangiocarcinoma on 26 February 2006.

After national service as medical officer to troops on Christmas Island, Ian Ross Russell practised briefly at Warminster before moving to Bishop's Stortford with his new wife, Hazel, in 1958. He joined his brother in law in practice with four colleagues, the practice moving to its current premises in 1964. Ian established the local vocational training scheme, acting as general practice trainer for many years, two of his trainees subsequently joining the practice as partners. He also worked as medical officer to two local schools, was area surgeon for St John Ambulance, and served for many years as local police surgeon and medical officer for the developing Stansted Airport. He leaves Hazel, three children, and 11 grandchildren.
Efficacy of HPA‐1a (Pl<sup>A1</sup>)‐negative platelets in a patient with post‐transfusion purpura
Authors: Alison Wakoff Loren, Charles S. Abrams
Journal: American Journal of Hematology (2004)

Abstract Post‐transfusion purpura (PTP) is a rare form of alloimmune thrombocytopenia that is self‐limited but which carries a 10–15% mortality related to fatal hemorrhage. Immunomodulatory therapies such as plasmapheresis and intravenous immunoglobulin G (IVIg) can shorten the duration of thrombocytopenia. However, in a bleeding patient with PTP, more urgent therapy may be required. Textbooks of hematology [1–3] as well as reports in the literature [4,5] suggest that patients do not respond to platelet transfusions. We report a case of PTP in a patient homozygous for HPA‐1b who suffered an intracranial hemorrhage. The patient was treated with IVIg and plasmapheresis. Because of her life‐threatening bleeding, we also transfused the patient with HPA‐1a‐negative platelets. These transfusions consistently resulted in transient improvements in her platelet counts and may have limited the degree of intracranial bleeding. Our experience suggests that transfusion of platelets that lack the offending epitope in patients with PTP may be efficacious. Am. J. Hematol. 76:258–262, 2004. © 2004 Wiley‐Liss, Inc.
Efficacy and Safety of Coadministration of Ezetimibe and Simvastatin in Adolescents With Heterozygous Familial Hypercholesterolemia
Authors: Anouk van der Graaf, Cynthia Cuffie-Jackson, Maud N. Vissers, Mieke D. Trip, Claude Gagné, Genming Shi, Enrico Veltri, Hans J. Avis, John J.P. Kastelein
Journal: Journal of the American College of Cardiology (2008)
SYNOVIAL FLUID T CELLS AND 65 kD HEAT-SHOCK PROTEIN
Authors: J.S.H. Gaston, P.F. Life, L. Bailey, P.A. Bacon, I.L. McLean, V.R. Winrow, P.I. Mapp, A.H. Cherrie, J.R. Archer, D.R. Blake
Journal: The Lancet (1988)
Pancuronium Bromide (Continued)
Authors: Fredrick K. Orkin
Journal: JAMA (1973)

To the Editor.—  Dr. Foldes (225:418, 1973) recently suggested that the excessive tachycardia noted by Dr. Beam (223:1044, 1973) and myself (224:630, 1973) following use of pancuronium bromide was due to unnecessarily large  of this muscle relaxant, and that the drug should not be used in patients with preexisting tachycardia. Both impressions are without substantiation in the literature.  Admittedly, Dr. Beam used very large doses to facilitate mechanical ventilation of an asthmatic child. Yet he was merely guided by the experience of Levin and Dillon (222:1265, 1972) who did not observe excessive tachycardia following similar doses in similar patients. Professor Foldes criticized my use of doses within the range (0.06 to 0.10 mg/kg) recommended by the manufacturer for tracheal intubation, suggesting that 0.06 mg/kg should be adequate. For the sake of brevity in the description of the most prominent tachycardia I observed, I did not mention that the use
Two Doses of HPV Vaccine May Be Sufficient
Authors: B. M. Kuehn
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Liability to alprazolam abuse in daughters of alcoholics
Authors: D A Ciraulo, O Sarid-Segal, C Knapp, A M Ciraulo, D J Greenblatt, R I Shader
Journal: American Journal of Psychiatry (1996)

The purpose of this study was to determine mood changes in women with a parental history of alcohol dependence (daughters of alcoholics) after challenge does of alprazolam and placebo in comparison with responses in women without a history of parental alcohol dependence.Visual analog scales that assess liability to benzodiazepine abuse were administered to 12 adult daughters of alcoholics and 11 comparison subjects after alprazolam challenge.The daughters of alcoholics had greater pleasant mood responses after a single dose of alprazolam than did the comparison subjects despite having similar plasma alprazolam levels.The findings of this study suggest that the mood-enhancing effects of alprazolam are greater in daughters of alcoholics than in subjects without a history of parental alcohol dependence.
A Paper on FILTERABLE VIRUSES AND PRACTICAL MEDICINE
Authors: S. P. Bedson
Journal: BMJ (1930)

I APPREcIATE 'the invitationi to open this discIIssionl, not as a p)ersonal lhoniour, hut riatlher as a complimnient to tlle laboratory w-orker, and an instance of that spirit of co-operation between the two branches of medicinie-- clinical and scientifict-which. is daily becomiling more intimate and consequently inore fruitful.There is olne point that I should like to biring into prominence.The cliniciani, facefl as lie is daily with the vital problems of disease, shoulll be, and often is, one of the great initiative forces in research.Sinoe my appointment to a researchl post at the London Hospital I have come to realize how stimulating a close contact with the clinical side of meclicine can be to the laboratorv worker.Bu-t for this to be
The Role of Data Audits in Detecting Scientific Misconduct
Authors: Stephen J. Rosenberg
Journal: JAMA (1990)

To the Editor.—  In the May 5, 1989, issue of JAMA , Drs Wyllie, Pippenger, and Rothner 1 were castigated by Nightingale et al of the Food and Drug Administration, 2 Robert Shulman of the Bolar Pharmaceutical Company, 2 and by the Deputy Editor (West) of JAMA . 3   This rather harsh criticism followed the article by Wyllie et al in which a patient was described with a static encephalopathy and a seizure disorder. During an October 1985 hospital admission her seizures were under reasonable control with a combination of Klonopin and Mysoline (500 mg/d) with a blood level for primidone of 10.8 mg/L. She then began experiencing increased seizure activity with a drop in her primidone level to 5.1 mg/L and subsequently to 2.0 mg/L despite a dosage increase. The reason for the drop in her level was ultimately found to have been secondary to generic primidone substituted for Mysoline by
All primary care trusts should set up teams to divert mentally ill offenders from prison
Authors: C. Dyer
Journal: BMJ (2009)

An England wide network of multidisciplinary teams to divert offenders with mental health problems from prison and provide treatment and support in the community will more than pay for itself in savings for the public purse, a report from a leading mental health charity has concluded.

The Sainsbury Centre for Mental Health reviewed the literature on the subject in the United Kingdom and abroad, made site visits to 16 diversion projects in England, and analysed value for money using the evidence gathered. It recommends that a diversion and liaison team for people with mental health problems who come into contact with the criminal justice system …
Five Perfect Fingers
Authors: John H. Vassall
Journal: JAMA (1983)

I was a third-year medical student on the obstetrics service. I had already delivered more than three dozen babies, all warm, wiggling, light, and joyous little things that brought smiles to everyone's lips. Three dozen times I saw the tension and pain of childbirth turn instantly to pleasure with the newborn's first cry. How different it had been tonight! I had just delivered the stillborn fetus of a diabetic primigravida. The mother was very obese and her diabetes had been out of control during her pregnancy. I had waited in agonizing silence for this baby. The collapsed skull entered the birth canal before complete cervical dilation had occurred. I spent an eternity whispering reassurances to the mother while waiting for passage of the baby's shoulders. Finally with a rush of fluid, the baby dropped, limp and heavy, into my hands like a bag of sand. I will never forget the
Bisphenol A diglycidyl ether as a potential metabolic source of bisphenol A.
Authors: D H Hutson
Journal: Environmental Health Perspectives (1998)

Bisphenol A Diglycidyl Ether as a Potential Metabolic Source of Bisphenol A * Ethylene glycol monobutyl ether-used as a solvent for mineral oils in spray lacquers, vamish removers, and metal cleaners * Glutaraldehyde-used as a disinfectant and sterilizing agent, and in adhesives, electrical products, dental materials, tanning of leathers, and photographic developing * Methyleugenol-used as an insect altrctant and as a maior constituent of clove oil, which is used in spices, perfumes, and favorings * Oxymetholone-used to promote weight gain and in the treatment of debilitafing diseases, serious infections, bums, trauma, and anemia * Triethanolamine-used in the manufacture of surfactants, textiles, waxes, polishes, herbicides, toilet goods, oil emulsions, and pharmaceuticals
Sodium Bicarbonate Versus Saline for the Prevention of Contrast-Induced Nephropathy in Patients With Renal Dysfunction Undergoing Coronary Angiography or Intervention
Authors: Mauro Maioli, Anna Toso, Mario Leoncini, Michela Gallopin, Delio Tedeschi, Carlo Micheletti, Francesco Bellandi
Journal: Journal of the American College of Cardiology (2008)
Relation of the metabolic syndrome to cardiac markers of preclinical disease: The strong heart study
Authors: Marcello Chinali, Richard B. Devereux, Barbara V. Howard, Mary J. Roman, Jonathan N. Bella, Jennifer E. Liu, Helaine E. Resnick, Elisa T. Lee, Lyle Best, Richard R. Fabsitz, Giovanni de Simone
Journal: Journal of the American College of Cardiology (2003)
Protein kinase C in heart failure: a therapeutic target?
Authors: S. S. Palaniyandi, L. Sun, J. C. B. Ferreira, D. Mochly-Rosen
Journal: Cardiovascular Research (2008)

Heart failure (HF) afflicts about 5 million people and causes 300 000 deaths a year in the United States alone. An integral part of the pathogenesis of HF is cardiac remodelling, and the signalling events that regulate it are a subject of intense research. Cardiac remodelling is the sum of responses of the heart to causes of HF, such as ischaemia, myocardial infarction, volume and pressure overload, infection, inflammation, and mechanical injury. These responses, including cardiomyocyte hypertrophy, myocardial fibrosis, and inflammation, involve numerous cellular and structural changes and ultimately result in a progressive decline in cardiac performance. Pharmacological and genetic manipulation of cultured heart cells and animal models of HF and the analysis of cardiac samples from patients with HF are all used to identify the molecular and cellular mechanisms leading to the disease. Protein kinase C (PKC) isozymes, a family of serine–threonine protein kinase enzymes, were found to regulate a number of cardiac responses, including those associated with HF. In this review, we describe the PKC isozymes that play critical roles in specific aspects of cardiac remodelling and dysfunction in HF.
An endocrine marker for pancreatic cancer.
Authors: Z. Tulassay, Z. Sandor, L. Bodrogi, J. Papp, T. Feher
Journal: BMJ (1988)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following An endocrine marker for pancreatic cancer. Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Abstract PR07: SNF5 is an essential executor of epigenetic regulation during differentiation
Authors: Jueng Soo You, Daniel D. De Carvalho, Chao Dai, Minmin Liu, Kurinji Pandiyan, Xianghong Zhou, Gangning Liang, Peter A. Jones
Journal: Cancer Research (2013)

Abstract Nucleosome occupancy controls the accessibility of the transcription machinery to DNA regulatory regions and serves an instructive role for gene expression. Chromatin remodelers, such as the BAF complexes, are responsible for establishing nucleosome occupancy patterns, which are key to epigenetic regulation along with DNA methylation and histone modifications. Some reports have assessed the roles of the BAF complex subunits and stemness in murine embryonic stem cells. However, the details of the relationships between remodelers and transcription factors in altering chromatin configuration, which ultimately affects gene expression during cell differentiation, remain unclear. Here for the first time we demonstrate that SNF5, a core subunit of the BAF complex, negatively regulates OCT4 levels in pluripotent cells and is essential for cell survival during differentiation. SNF5 is responsible for generating nucleosomedepleted regions (NDRs) at the regulatory sites of OCT4 repressed target genes such as PAX6 and NEUROG1, which are crucial for cell fate determination. Concurrently, SNF5 closes the NDRs at the regulatory regions of OCT4 activated target genes such as OCT4 itself and NANOG. Furthermore, using loss and gain of function experiments followed by extensive genome-wide analyses including gene expression microarrays and ChIP-sequencing, we highlight that SNF5 plays dual roles during differentiation by antagonizing the expression of genes that were either activated or repressed by OCT4, respectively. Together, we demonstrate that SNF5 executes the switch between pluripotency and differentiation. This abstract is also presented as Poster A39. Citation Format: Jueng Soo You, Daniel D. De Carvalho, Chao Dai, Minmin Liu, Kurinji Pandiyan, Xianghong Zhou, Gangning Liang, Peter A. Jones. SNF5 is an essential executor of epigenetic regulation during differentiation. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Jun 19-22, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2013;73(13 Suppl):Abstract nr PR07.