tbuckley/cabot-search huggingface dataset:
Electrocardiographic Predictors of Arrhythmic Death and Total Mortality in the Multicenter Unsustained Tachycardia Trial
Authors: Peter J. Zimetbaum, Alfred E. Buxton, William Batsford, John D. Fisher, Gail E. Hafley, Kerry L. Lee, Michael F. O’Toole, Richard L. Page, Matthew Reynolds, Mark E. Josephson
Journal: Circulation (2004)

Background— Stratifiers of sudden and total mortality risk are needed to optimally target preventive therapies in patients with coronary artery disease and impaired ventricular function. We assessed the prognostic significance of ECG markers of conduction abnormalities and left ventricular hypertrophy in the Multicenter Unsustained Tachycardia Trial (MUSTT). Methods and Results— We analyzed the ECGs of 1638 patients from MUSTT who did not receive antiarrhythmic therapy (antiarrhythmic medication or implantable cardioverter-defibrillator). After adjustment for other significant factors, left bundle-branch block and intraventricular conduction delay were associated with a 50% increase in the risk of both arrhythmic and total mortality. Right bundle-branch block was not associated with arrhythmic or total mortality. Left ventricular hypertrophy was the only ECG predictor of arrhythmic (hazard ratio, 1.35; 95% CI, 1.08 to 1.69) but not total mortality. Conclusions— In patients with coronary artery disease, depressed left ventricular function, and nonsustained ventricular tachycardia, QRS prolongation resulting from left bundle-branch block or intraventricular conduction delay but not right bundle-branch block provided prognostic information about the risk of arrhythmic and total mortality independently of electrophysiological evaluation and ejection fraction. Left ventricular hypertrophy was associated with increased arrhythmic but not total mortality.
Percentage of Smudge Cells on Routine Blood Smear Predicts Survival in Chronic Lymphocytic Leukemia
Authors: Grzegorz S. Nowakowski, James D. Hoyer, Tait D. Shanafelt, Clive S. Zent, Timothy G. Call, Nancy D. Bone, Betsy LaPlant, Gordon W. Dewald, Renee C. Tschumper, Diane F. Jelinek, Thomas E. Witzig, Neil E. Kay
Journal: Journal of Clinical Oncology (2009)

Smudge cells are ruptured chronic lymphocytic leukemia (CLL) cells appearing on the blood smears of CLL patients. Our recent findings suggest that the number of smudge cells may have important biologic correlations rather than being only an artifact of slide preparation. In this study, we evaluated whether the smudge cell percentage on a blood smear predicted survival of CLL patients. We calculated smudge cell percentages (ratio of smudged to intact cells plus smudged lymphocytes) on archived blood smears from a cohort of previously untreated patients with predominantly early-stage CLL enrolled onto a prospective observational study. The relationship between percentage of smudge cells, patient survival, and other prognostic factors was explored. Between 1994 and 2002, 108 patients were enrolled onto the study and had archived blood smears available for review; 80% of patients had Rai stage 0 or I disease. The median smudge cell percentage was 28% (range, 1% to 75%). The percentage of smudge cells was lower in CD38(+) versus CD38(-) patients (P = .019) and in Zap70-positive versus Zap70-negative patients (P = .028). Smudge cell percentage as a continuous variable was associated with prolonged survival (P = .042). The 10-year survival rate was 50% for patients with 30% or less smudge cells compared with 80% for patients with more than 30% of smudge cells (P = .015). In multivariate analysis, the percentage of smudge cells was an independent predictor of overall survival. Percentage of smudge cells on blood smear is readily available and an independent factor predicting overall survival in CLL.
An Introduction to Neurosurgery
Authors: Oscar Sugar
Journal: JAMA (1965)

Intended to increase general awareness of what the neurosurgeon can and cannot do, this book deals at relative length with a few selected topics. Anatomic and physiological detail have been restricted, and principles of operations are given rather than details. The first group of chapters proceeds from diagnosis, pathology, and treatment of intracranial masses to the peculiarities of common types of tumor. The three chapters on head injury summarize current views of pathology, and the medical and operative management. Among vascular lesions discussed are aneurysms, angioma, intracerebral hemorrhage, and occlusive cerebrovascular disease. Many would concur that brain abscesses should be treated by burr hole drainage, but not that intrathecal medication should be used for meningitis.  Spinal infections are included in chapters on spinal compression, again beginning with general principles of diagnosis and then proceeding to specific disease entities. Anterolateral decompression may come as a surprise to readers having limited experience
Abnormal movements can be identified in “atypical” populations
Authors: J. G. Phillips, J. L. Bradshaw, M. J. Slavin, C. Pantelis
Journal: Behavioral and Brain Sciences (1996)

Abstract Latash &amp; Anson's discussion of movements of “atypical” populations is potentially topical but unhelpful. Abnormal movements can be distinguished from any compensatory adjustments in Parkinson's, Huntington's, and Alzheimer's diseases and schizophrenia. To suggest otherwise may do “atypical” populations and their caregivers a disservice. It would be more meaningful to discuss the relative modularity and separability of cognitive and motor processes.
A history of health education in the United States
Authors: Fred V. Hein
Journal: JAMA (1962)

This volume represents a scholarly effort to trace the history of school and college health education in the United States. Although the general term "health education" is used in the title, the text is concerned primarily with organized education in the school and college setting rather than with public health education provided through voluntary, professional, governmental, and other agencies. Health education in the schools and colleges of the United States began in colonial days with the development of the academy and its "new" curriculum. A "healthful situation" was a major goal in these schools, and physical exercise was one of the primary subjects. The most tangible early evolvement of health education came about from 1787-1850. By the end of this period physiology, hygiene, physical training, and attention to the environment had become routine in many schools and colleges. In subsequent decades there was increasing organization of health education in terms
IgE Reactivity to Tropomyosins of Periplaneta americana, Shrimp and Ascaris lumbricoides in Patients Allergic to Cockroach and Shrimp
Authors: A.B.R. Santos, S.C. Arruda, M.C.R. Barbosa, L.K. Arruda
Journal: Journal of Allergy and Clinical Immunology (2009)
Abstract SY10-02: Breast cancer subtypes have selective kinome reprogramming in response to kinase inhibitors.
Authors: Gary Johnson
Journal: Cancer Research (2013)

Abstract Multiplexed Inhibitor Beads coupled with quantitative Mass Spectrometry (MIB/MS) allows study of over 60-70% of the expressed kinome simultaneously using lysates from cell lines, mouse tumors and human specimens. Cells or tumors are assessed before and after addition of agonists or inhibitors. Results show a systems kinome reprogramming in response to highly selective inhibitors that creates inhibitor resistance. The activation signatures and changes in the kinome activation profile (kinome reprogramming) are unique for each breast cancer subtype (Luminal, HER2+, Basal-like, Claudin-low) in response to highly selective, clinically relevant kinase inhibitors (MEKinh, mTOR/PI3Kinh). Window trials in patients with TNBC have shown kinome reprogramming in response to MEKinh, suggesting understanding kinome resiliency is necessary for rational design of effective combination therapies to treat cancer in individual patients. Citation Format: Gary Johnson. Breast cancer subtypes have selective kinome reprogramming in response to kinase inhibitors. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr SY10-02. doi:10.1158/1538-7445.AM2013-SY10-02
The Dentition of the Kostroma People
Authors: C. S. Tomes, O. Coles
Journal: BMJ (1874)

tions in the amount of blood-flow; 2. That they do depend on altera- tions in the nerve-tissue effected, as all neuroses are, either by exhaus- tion, toxzemia, or remote irritation; 3.That the morbid processes giving rise to these states are diverse, and yet have much affinity, and may exist together; 4. That hyperexcitability, as a necessary result,
(31) Lichenoid tattoo reaction
Authors: I.H. Coulson, K.V. Sanderson
Journal: British Journal of Dermatology (1985)

Journal Article (31) Lichenoid tattoo reaction Get access I.H. Coulson, I.H. Coulson St George's Hospital, London SW17 Search for other works by this author on: Oxford Academic Google Scholar K.V. Sanderson K.V. Sanderson St George's Hospital, London SW17 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Page 76, https://doi.org/10.1111/j.1365-2133.1985.tb13046.x Published: 01 July 1985
A 28-Year-Old Fair-Skinned Woman With Multiple Moles
Authors: June K. Robinson
Journal: JAMA (1997)

<h3>Dr DALEY:</h3> Ms G is a 28-year-old single health care office worker who has had 2 abnormal moles removed in the past. She lives in greater Boston and is engaged to be married. Her health insurance is through a managed care plan in eastern Massachusetts. In 1994, a physician with whom Ms G works noted a "funnylooking" mole on her left ear and suggested that she have it evaluated. Ms G sought consultation from Dr V, a dermatologist, who noted more than 50 nevi over her body and 2 abnormal-appearing moles: one on her left ear and another on her anterior abdominal wall. Physical examination revealed each mole had the appearance of a dysplastic nevus. After a biopsy in October 1994, the ear lesion was noted to be a "lentiginous compound nevus with architectural features of a dysplastic nevus; the cytologic atypia is mild." The anterior abdominal wall lesion was
Epstein-Barr-Virus Immunity and Tissue Distribution in a Fatal Case of Infectious Mononucleosis
Authors: S. Britton, M. Andersson-Anvret, P. Gergely, W. Henle, M. Jondal, G. Klein, B. Sandstedt, E. Svedmyr
Journal: New England Journal of Medicine (1978)

INFECTIOUS mononucleosis is usually a self-limited lymphoproliferative disease caused by the Epstein–Barr virus.1 However, fatal cases do occur. Up until 1970 only 20 deaths due to infectious mononucleosis had been reported in which both hematologic and serologic (heterophil-antibody) diagnostic requirements were met.2 By far the most common cause of death was found to be neurologic complications, splenic rupture only accounting for 15 per cent of the deaths.2 It is clear that very efficient regulatory mechanisms must be operative during infectious mononucleosis, since the formidable lymphoid proliferation seen in this disease is almost invariably terminated and lymphoid tissue returns to its . . .
HEMODYNAMIC CARDIAC STRESS INDUCED MYOCARDIAL ISCHEMIA AS DETECTED BY THE RELEASE OF CARDIAC BIOMARKERS: CARDIAC TROPONIN T AND I, CK-MB AND MYOGLOBIN
Authors: Affan Irfan, Tobias Reichlin, Rapahel Twerenbold, Karin Wildi, Christian Mueller
Journal: Journal of the American College of Cardiology (2013)
BELL'S MANIA
Authors: S. H. Kraines
Journal: American Journal of Psychiatry (1934)

(1) There are cases of acute excitement that are classified under several headings with apparently no recognition as to the uniformity of symptomatology. These cases have been diagnosed as Bell's Mania, typhomania, acute delirious mania (manic-depressive psychosis), delirium grave, acute delirium, specific febrile delirium, and collapse delirium. (2) Luther Bell described these cases in 1849 and the description is slightly modified as follows: There is a sudden onset; exceedingly great overactivity; marked sleeplessness; great push of speech with statements that are disconnected at times by reason of the rapidity of flow; disconnected and poorly systematized delusions; transient hallucinations that border on illusions; appearance of confusion, but when one insists that the patient answer the questions, the patient can "suspend the intellectual wanderings" long enough to answer correctly as to orientation. The course of the illness is from three to six weeks, with a fatal termination in a large percentage of cases, apparently from cardio-vascular failure due to overactivity. The cases that recover have no after symptoms. No pathological evidence of note has been found by later workers. (3) Treatment is recommended in the form of sufficient sedative, regardless of the dosage, to enable the patient to get some rest. In our case ordinary sedatives failed and though over 125 grains of sodium amytal were given in three days the patient slept comparatively little. However, the overexcitement was quelled. (4) For the sake of clarity in the studying of this group, and until more definite findfngs are brought forth, it is suggested that these cases be called Bell's Mania, after the original observer.
The Medical Aspects of Dance
Authors: Paula Willcock
Journal: British Journal of Sports Medicine (1987)

Furthermore, the probes exhibited 100% response times of approximately 60 s to square wave stimuli of 10'C.While the leads used in our laboratory are only 4 m in length, Nicholls (1983) stresses that the AD 590 transducer is particularly useful for remote sensing applications since it is insensitive to voltage drops over long lines because of its high impedance current output. SAFETY PRECAUTIONSAfter use the rectal probe was scrubbed in a warm Savlon solution to remove all traces of faeces.It was then disinfected by immersion for at least 60 min in undiluted, glutaraldehyde based 'Wavicide-Aid(T.M.)" in accordance with the recommendations of the Australian AIDS Task Force (1985).The electronic equipment satisfied the requirements of the Standards Association of Australia (1980).
PARASITIC UTERINE MYOMATA.
Authors: THOMAS S. CULLEN
Journal: JAMA (1907)

By this term we mean myomata that have for some reason become partially or almost completely weaned away from the uterus and receive their main blood supply from another source. Uterine myomata, while primarily getting their entire nourishment from the uterus, may in time derive the greater part of it from: 1, The omentum; 2, large or small bowel; 3, bladder; 4, mesenteric vessels; 5, Fallopian tube; or from several sources at the same time. We are here chiefly interested in the rôle that the omentum plays where the myoma gradually changes its source of blood supply. The following pages will show beyond peradventure that the omentum is the guardian of the abdominal organs. In many cases where myomata exist the omental adhesions areassociated with dense pelvic adhesions or with pus tubes. Here it is perfectly natural that the omentum should become firmly adherent. We are interested chiefly in that
THE DETERMINATION OF SODIUM IN BODY FLUIDS BY THE GLASS ELECTRODE*
Authors: Edward W. Moore, Donald W. Wilson
Journal: Journal of Clinical Investigation (1963)

The use of glass electrodes for the determina- tion of pH is well established.The possibility of measuring alkali ions in biological fluids by an electrode potential offers several advantages over other physical methods such as flame photometry (2).Since the publication of work by Eisenman, Rudin, and Casby (3) in 1957 demonstrating that the ternary glass system
31 NOVEL METHOD TO ISOLATE AND EXPAND EPCAM+CD24+ CD133+ ADULT HEPATIC PROGENITOR CELLS WITH LIVER REPOPULATION CAPACITY
Authors: W.Y. Lu, A. Tsuchiya, L. Boulter, R.V. Guest, T.G. Bird, M.J. Williams, D.C. Hay, J.P. Iredale, S.J. Forbes
Journal: Journal of Hepatology (2013)
Primary Carcinoma of the External Auditory Meatus
Authors: P. Dubs
Journal: BMJ (1948)

MeatusPrimary carcinoma of the external auditory meatus is usually considered a rare disease.It is probably not so rare as is generally thought, but can be diagnosed only by biopsy.The early symptoms are aural discomfort, intense and continuous earache, and aural discharge.Local extension is rapid and glandular metastasis rare.Treatment in the early stage is by excision with the diathermy knife, combined in the later stage with radium beam therapy. ILLUSTRATIVE CASESCase 1.-Madame Le S., aged 46, was first seen on May 23, 1944, complaining of rapidly increasing deafness in the right ear, together with a slight purulent aural discharge and mild intermittent pain.Her symptoms were of only one month's duration.There was no -history of otitis media.Examination revealed a small papillomatous mass deep in the meatus on the postero-superior wall and hiding the drum.The rest of the meatus was the seat of a chronic eczema.A slight fetid purulent discharge was noted.There was a slight diminution in hearing (transmission deafness).Vestibular apparatus was normal.Radiography was negative.A first biopsy gave a doubtful result, but a second, a fortnight later, revealed the presence of a squamous-celled epithelioma.A radical mastoidectomy was performed at the end of June, the whole of the skin of the posterior wall of the meatus being removed.Some inflammatory granulations Physician to the Middlesex Hospital.
Oxidant stress in asthma
Authors: R. Dworski
Journal: Thorax (2000)

Asthma is a chronic inflammatory disease of the respiratory tract of unknown aetiology.In severe asthma airway diathesis is profound, and thus apparent.Recently, however, evidence has indicated that specific inflammatory abnormalities exist even in the airways of subjects with mild disease.As inflammation is often associated with an increased generation of reactive oxygen species (ROS), and the biochemical environment in the asthmatic airways is favourable for free radical mediated reactions, it is rational to surmise that an oxidant stress could be mechanistically important in asthma.
Anti-ribosomal P protein antibodies detected by immunoblotting in patients with connective tissue diseases: their specificity for SLE and association with IgG anticardiolipin antibodies
Authors: A Ghirardello
Journal: Annals of the Rheumatic Diseases (2000)

<h3>OBJECTIVE</h3> To assess the prevalence and clinical and serological associations of anti-ribosomal P protein antibodies (anti-P antibodies) in patients with connective tissue diseases (CTDs) and investigate the immunobiological nature of autoantibody clustering in which anti-P antibodies play a part. <h3>METHODS</h3> IgG anti-P antibodies in the sera of 267 patients with CTDs and 31 healthy subjects were analysed by immunoblotting performed on cytoplasmic extract of Raji cells. 60 patients with systemic lupus erythematosus (SLE), 32 systemic sclerosis, 46 primary Sjögren9s syndrome, 16 poly/dermatomyositis, 11 rheumatoid arthritis, 8 undifferentiated CTD, 72 overlap CTD, and 22 primary antiphospholipid syndrome were studied. Anti-P antibodies were affinity purified by elution from nitrocellulose bound antigen and tested by ELISA for their binding activity to cardiolipin. <h3>RESULTS</h3> Anti-P antibodies were detected in 16 (6%) patients and in none of the controls: 12/60 SLE (20%) and 4/80 undifferentiated/overlap patients with CTD (5%). A close association of IgG antibodies with P proteins and with cardiolipin was seen in lupus sera (p=0.0009, odds ratio 18.33). Anti-P antibodies from 9 of 12 anti-P lupus serum samples could be affinity purified and none of the affinity purified fractions cross reacted with ELISA plate coated cardiolipin. <h3>CONCLUSIONS</h3> Anti-P immunoreactivity is a specific marker of SLE and lupus-like disease and its detection is recommended as a powerful diagnostic tool. Anti-P antibodies are strongly clustered with IgG anticardiolipin antibodies in lupus sera, even if they are independently elicited. This suggests that their cognate autoantigens play a part in a common pathogenetic pathway in SLE.
Gastro-Intestinal Blood Loss Measured by Radioactive Chromium
Authors: A. D. Cameron
Journal: Gut (1960)

A new technique is described for the measurement of blood loss in the faeces of patients labelled with radioactive chromium ((51)Cr). The method is simple and is probably more accurate at low levels of faecal radioactivity than those previously described. The method will measure as little as 0.02muC of (51)Cr in whole blood in a 24-hour stool. The apparent average daily blood loss in a series of 10 normal people averaged 0.6 ml., with a range of 0.3 to 1.3 ml. Estimations of plasma and salivary radioactivity have been made in an attempt to assess the importance of contamination from eluted (51)Cr. Minor radioactivity in plasma but none in saliva was recorded. Stool contamination from such sources is thought to be insignificant. No significant correlation existed between chemical occult blood tests and isotope measurements, where there was less than 10 ml. of whole blood in a 24-hour stool.
Abstract 4030: Resuscitation with Intraosseous Infusion of Artificial Oxygen Carrier of Liposome-Encapsulated Hemoglobin (LHb) from Lethal Hemorrhagic Shock and Its Effect on Cytokines
Authors: Bonpei Takase, Satoshi Shono, Manabu Kinoshita, Yashiro Nogami, Yoshitaka Ogata, Hidemi Hattori, Masayuki Ishihara
Journal: Circulation (2008)

Liposome-encapsulated hemoglobin (LHb), which is structurally similar to red blood cells (RBC) except smaller size (250 nm), can serve as blood substitute comparable to RBC. We have reported that intraosseous blood infusion (IOI) is effective treatment in shock mice model. IOI is alternative to peripheral i.v. infusion and is expected as an important field treatment in civilian emergency because of no collapse of intramedullary blood vessels in the bone marrow in shock. However, we did not evaluate the side effects of LHb in IOI. Total 70% hemorrhagic shock was induced by femoral vein bleeding. Immediately after bleeding, 17 mice were resuscitated with tibial bone IOI of 5% albumin (5% albumin), 18 mice resuscitated with mouse-washed RBC (Wash RBC) and 14 mice resuscitated with LHb (LHb-group). Survival rates were compared and the temporal changes in cytokins (TNF, INFγ) as well as liver and renal function (s-ALT, s-creatinine) were measured. All mice survived 48 h after IOI of LHb whereas only 47% and 45% mice survived in 5% albumin and Wash RBC, respectively (Fig. 1 ). The changes in TNF and INFγlevels after IOI were not statistically different among 3 groups (Fig. 2 ) and no side effects were found on liver and renal function.. Conclusions: LHb has a better anti-shock effect than RBC by using IOI probably due to smaller size and IOI of LHb could be useful in disaster medicine. In addition, IOI of LHb shows no significant effects on cytokins, liver and renal function. Figure 1 Figure 2