tbuckley/cabot-search huggingface dataset:
Rectus Abdominis Muscle Metastasis From Papillary Thyroid Cancer Identified by I-131 SPECT/CT
Authors: Li-xia Zhao, Lin Li, Fang-lan Li, Zhen Zhao
Journal: Clinical Nuclear Medicine (2010)

The major sites of distant metastases of differentiated thyroid cancer are cervical lymph nodes, lungs and bones and the minor sites include the brain, liver, kidney, skin, pleura, and muscle. Skeletal muscle, especially a rectus abdominis muscle metastasis from thyroid cancer, is extremely rare. In this report, a 53-year-old man with papillary thyroid cancer was treated with I-131 for the ablation of a postsurgical thyroid remnant. An incidental focus of abnormally increased I-131 uptake in the left abdomen was observed on a I-131 whole-body scan. Subsequent single photon emission computed tomography/computed tomography (SPECT/CT) scan showed the focus was located in the left rectus abdominis muscle. The lesion was surgically removed and pathologically confirmed as a metastasis.
Abstract 2859: Major Improvement in In-Hospital Mortality after STEMI from 2000 to 2005 in Relation to Improved Early Management: Results from the French USIC 2000 and FAST-MI Registries
Authors: Nicolas Danchin, Didier Blanchard, Claude Barnay, Pierre Coste, Pascal Gueret, Khalife Khalife, Jean-Louis Neimann, Loic Belle, Jean-Pierre Cambou, Fast-Mi investigators
Journal: Circulation (2006)

Background: The use of reperfusion therapy and recommended medications has increased in recent years; the relation of better implementaion of recommendations with outcomes deserves clarification. A...
Attenuated vasodilator responses to Mg2+ in young patients with borderline hypertension.
Authors: T Fujita, Y Ito, K Ando, H Noda, E Ogata
Journal: Circulation (1990)

Limb vascular responses to magnesium (Mg2+) and potassium (K+) ions were studied in 19 young patients with borderline hypertension (BHT) and compared with those of 22 age-matched normotensive subjects (NT) by measuring the forearm blood flow response to intra-arterial infusion of magnesium sulfate and potassium chloride using venous occlusion plethysmography. Percent decrements of forearm vascular resistance with Mg2+ infusions were significantly less in BHT subjects than in NT (-37.2 +/- 4.2% versus -53.0 +/- 2.0%, p less than 0.05, during the infusion of 0.1 meq Mg2+/min, and -52.2 +/- 4.3% versus -65.6 +/- 1.5%, p less than 0.05, during the infusion of 0.2 meq Mg2+/min). Moreover, the relation of the magnitude of Mg2+ response to initial vascular resistance in six of 10 BHT subjects lies above the 95% confidence interval for predicted values calculated for response points in 11 NT subjects, suggesting attenuated vasodilator responses of Mg2+ in a significant proportion of BHT subjects. In contrast, the response points to K+ in eight of nine BHT subjects fall within the 95% confidence interval, suggesting normal vasodilator responses to K+ in the majority of BHT subjects. Furthermore, the effect of small increments in local serum calcium concentrations on Mg2(+)- and K(+)-induced vasodilation was studied in normal volunteers. Isosmolar CaCl2 solution infused into the same brachial artery at a rate of 0.09 meq/min severely blunted the vasodilating actions of Mg2+ (-30.1 +/- 6.5% versus -65.8 +/- 3.2%, p less than 0.01, during the infusion of 0.2 meq Mg2+/min) but did not affect those of K+ (-63.1 +/- 3.1% versus -55.9 +/- 3.8%, NS, during the infusion of 0.154 meq K+/min). It appears that Mg2(+)-induced vasodilation should be due to the antagonistic action of Mg2+ to calcium, but K(+)-induced vasodilation might not be directly related to calcium movement. Thus, these attenuated responses to Mg2+ but normal responses to K+ in BHT subjects may indicate an underlying defect in vascular Mg2+ metabolism, which ultimately may be related to the alterations in calcium handling by plasma membranes rather than to the abnormalities of membrane Na(+)-K+ pump activity.
Trochanteric Bursitis: Bone Scan Appearance
Authors: S J ALLWRIGHT, R A COOPER, P NASH
Journal: Clinical Nuclear Medicine (1988)

Trochanteric bursitis is one of the most common soft tissue abnormalities in the hip region, yet it is frequently underdiagnosed. There is a characteristic pattern of uptake seen on the bone scan in patients with this condition. Its recognition is important to avoid misinterpretation of increased trochanteric uptake, particularly in patients with malignant disease, and to aid in the diagnosis and effective management of this treatable condition.
Dutch want publication of data on heart surgery
Authors: Tony Sheldon
Journal: BMJ (2006)

Heart surgery centres in the Netherlands are being urged to provide data on mortality and morbidity after a university hospital was ordered to halt operations when inspectors confirmed “abnormally high” death rates.

Adult heart surgery at the St Radboud University Medical Centre in Nijmegen, has been stopped for an unspecified time after the Health Care Inspectorate concluded that the “safety and quality” of care could not be guaranteed.

The independent report was ordered by …
Ethanol-induced liver injury and changes in sulfur amino acid metabolomics in glutathione peroxidase and catalase double knockout mice
Authors: Sun J. Kim, Joo W. Lee, Young S. Jung, Do Y. Kwon, Hee K. Park, Chang S. Ryu, Sang K. Kim, Goo T. Oh, Young C. Kim
Journal: Journal of Hepatology (2009)
New insights into the classification and mechanisms of hereditary, chronic, non-haemolytic hyperbilirubinaemias
Authors: P. Berthelot, D. Dhumeaux
Journal: Gut (1978)

Gilbert9s syndrome is typically associated with a deficiency in hepatic bilirubin UDP-glucuronosyltransferase activity (B-GTA). The overproduction of bilirubin that is often found in this condition could be a fortuitous coincidence that leads to the unmasking of the disease, which otherwise often remains latent. Some cases of chronic unconjugated hyperbilirubinaemia could, however, be related to a defect in hepatic uptake, as reflected by alterations in BSP kinetics. Severe deficiencies of hepatic B-GTA exist in all types of Crigler-Najjar disease. An increased proportion of bilirubin monoglucuronide is always found in bile when a B-GTA deficiency is present. This observation strongly suggests a common biochemical defect in Gilbert9s syndrome and in Crigler-Najjar disease, and thus renders the suggestion that the latter condition may be separated into two groups somewhat inappropriate. There is, however, no doubt that further knowledge of the conjugating enzyme, or enzymes, is required: such information may lead to the characterisation of several types of enzymic defects. Whereas little is new as far as the Dubin-Johnson syndrome is concerned, Rotor9s syndrome can no longer be considered to be a variant of the former. The transport defect which is involved in most cases of Rotor9s syndrome, if not in all, is an impairment of hepatic storage, thus distinguishing it from the impairment of excretion which is involved in the Dubin-Johnson syndrome. The distinct patterns of urinary coproporphyrin excretion, which were recently reported in Dubin-Johnson and Rotor9s syndromes, offer additional evidence for a clear differentiation between these two entities.
Left Ventricular Thrombus Identification A Scintigraphic and Echocardiographic Correlation
Authors: D SCHECHTER, M BOCHER, D GILON, R CHISIN
Journal: Clinical Nuclear Medicine (1993)

A prominent and protruding left ventricular filling defect was noted on a routine radionuclide ventriculogram in a patient with congestive heart failure. An echocardiogram further documented the existence of a septal thrombus, which was suspected by radionuclide ventriculogram.
Queries and Minor Notes
Authors: Geza de Takats
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Gray Zone Between Burkitt's Lymphoma and Diffuse Large B-Cell Lymphoma From a Genetics Perspective
Authors: Itziar Salaverria, Reiner Siebert
Journal: Journal of Clinical Oncology (2011)

It has long been recognized that the border between classical Burkitt's lymphoma (BL) and classical diffuse large B-cell lymphoma (DLBCL) is hard to determine. Instead, both classical lymphoma entities seem to be the extreme ends of a spectrum of diseases that contains a group of lymphomas characterized predominately by the fact that they are hard to assign to the one or the other group. This gray zone has been recently termed “lymphoma, unclassifiable, with features intermediate between DLBCL and BL” by the updated WHO classification. The term “intermediate” resembles that from a recent gene-expression study of mature aggressive B-cell lymphomas, although, notably, it is used differently. Intermediate lymphomas according to the WHO classification clearly are a temporary container of different biologic subtypes of aggressive lymphoma, from which several might be associated with an unfavorable clinical outcome. The present review aims at describing the morphologic, clinical, and biologic heterogeneity of the intermediate lymphomas and, moreover, attempts to propose testable subgroups based on age and presence of genetic aberrations.
Lipids and the Steroid Hormones in Clinical Medicine: Proceedings of an Applied Seminar of the Association of Clinical Scientists
Authors: Harley Cluxton
Journal: JAMA (1961)

This book consists of collected papers which outline laboratory procedures for estimating the various lipids and steroid hormones. There is little continuity of the collected data from one chapter to the next. The clinical interpretation and application are meager. The book, therefore, should be more useful to the biochemist or physician interested in basic analytical research than to the practicing or clinical investigative physician.
A double‐blind dose‐response study of budesonide by inhalation in patients with bronchial asthma
Authors: S.‐Å. Johansson, R. Dahl
Journal: Allergy (1988)

Budesonide by inhalation and placebo were tested in 18 patients with moderate chronic bronchial asthma. Three dose levels of budesonide were used (25, 100 and 400 μg q.i.d.) and the patients were to take two puffs q.i.d. in all periods. The active treatment was investigated using double‐blind cross‐over technique, and placebo at the end of the trial. The duration of each treatment period was 2 weeks. The study showed a high drop‐out frequency while on placebo and that the PEF values were influenced in a dose‐dependent way by budesonide. In spite of the double‐blindness the patients had a tendency towards overuse of the trial aerosol on the lowest dose, but they used significantly less than prescribed during the period with the highest dose. No side effects were reported.
Methylation Subtypes and Large-Scale Epigenetic Alterations in Gastric Cancer
Authors: Hermioni Zouridis, Niantao Deng, Tatiana Ivanova, Yansong Zhu, Bernice Wong, Dan Huang, Yong Hui Wu, Yingting Wu, Iain Beehuat Tan, Natalia Liem, Veena Gopalakrishnan, Qin Luo, Jeanie Wu, Minghui Lee, Wei Peng Yong, Liang Kee Goh, Bin Tean Teh, Steve Rozen, Patrick Tan
Journal: Science Translational Medicine (2012)

A large-scale genomic survey of epigenetic alterations in gastric cancer identifies clinically relevant molecular subgroups.
The Doubtful Syphilitic Blood Test in Pregnancy
Authors: F. J. G. Jefferiss
Journal: BMJ (1954)

tant solutions, might help to reduce the incidence of the infection in cattle.Early treatment of infected cattle would obviously lessen the risk to farm workers. SummaryThe literature on cattle ringworm and its transmission to man is reviewed.The disease is still frequent in some rural areas of Britain, but its real incidence is unknown.Most infections in this country are caused by Trichophyton discoides, but Tr. menitagrophytes is responsible for some cases.The records of 39 human cases observed in South Wales are analysed, and an account is given of the course and clinical features of the infection in man and cattle.Treatment is briefly discussed.The acutely inflam- matory infections are self-limiting, and the patient's dis- comfort is increased by irritating fungicides, which do not shorten the course of the disease and may produce a contact dermatitis.Active treatment should be reserved for the less-acute cases.
Histological and histochemical changes in the columnar lined (Barrett's) oesophagus.
Authors: G A Rothery, J E Patterson, C J Stoddard, D W Day
Journal: Gut (1986)

Multiple endoscopic specimens were obtained from 58 patients with a columnar lined gesophagus to study the histological and histochemical features of this metaplastic epithelium. Five patients (8.6%) had presented with a primary oesophageal adenocarcinoma. Three different epithelial types, junctional, atrophic fundic and intestinal were identified. Twenty two (38%) patients had just one type of epithelium present, the other 36 (62%) having a combination of two or three different types. Intestinal type of epithelium, either alone or in combination with gastric type epithelium was present in 48 (83%) patients. In every case this intestinal type epithelium took the form of an incompletely differentiated variant of intestinal metaplasia, although complete intestinal metaplasia as a focal change was also present in 14 of these patients. Histochemically, sulphomucins were present in the biopsies of 43 (74%) of the patients studied. They were seen in both goblet and columnar mucous cells with almost equal frequency. Incomplete intestinal metaplasia with sulphomucin production was present in four of the five patients with an oesophageal adenocarcinoma. In the columnar lined oesophagus sulphomucin production is common and its presence does not help to identify those individuals at particular risk of developing an adenocarcinoma.
T-type Ca2+ channels are abnormal in genetically determined cardiomyopathic hamster hearts.
Authors: L Sen, T W Smith
Journal: Circulation Research (1994)

Although there is substantial evidence of abnormal Ca2+ homeostasis in heart cells of the cardiomyopathic Syrian hamster (Bio 14.6 strain), the mechanism by which these myocytes become Ca(2+)-overloaded is not known. To elucidate the role of voltage-sensitive Ca2+ channels in the pathogenesis of myopathy, whole-cell Ca2+ currents were measured in myopathic and normal control cardiac myocytes. These studies demonstrate the presence of two voltage-sensitive Ca2+ channel types in ventricular myocytes isolated from 200- to 300-day-old cardiomyopathic and age-matched normal hamsters. The two Ca2+ channel types were identified by their unitary conductance properties and pharmacologic sensitivities. Both L-type and T-type Ca2+ channels were present in cardiomyopathic and normal cells. Current density through L-type Ca2+ channels was the same in cardiomyopathic and normal control myocytes. However, the mean current density of T-type Ca2+ channels in cardiomyopathic cells was significantly higher than in normal cells (myopathic, 12.3 +/- 1.8 pA/pF; normal, 5.8 +/- 1.1 pA/pF; n = 8; P < .01). The T-type Ca2+ current in cardiomyopathic myocytes was activated and inactivated at more negative potentials than in cells from normal hamster hearts. These findings demonstrate no abnormality of the dihydropyridine-sensitive voltage-dependent L-type Ca2+ channel. In contrast, the observed abnormalities in T-type Ca2+ channel function in cardiomyopathic hamster myocytes suggest that this alteration may be related to the pathogenesis of Ca2+ overload and the arrhythmias in this genetically determined form of cardiomyopathy.
MANAGEMENT OF LESIONS OF THE STOMACH AND DUODENUM COMPLICATED BY HEMORRHAGE
Authors: DONALD C. BALFOUR
Journal: JAMA (1927)

The treatment of gastric hemorrhage per se is in some dispute, but there are certain facts which I believe are generally recognized, the most important of which is that death from a single massive hemorrhage from peptic ulcer is rare. Death may result indirectly in such cases because of continuous bleeding or from repeated hemorrhages recurring at short intervals, but with proper management of the case a fatal outcome is also rare. For these reasons the surgical treatment of acute massive gastric hemorrhage, regardless of its cause, is avoided by surgeons because it is attended by a higher mortality than nonsurgical treatment. On the contrary, however, when hemorrhage from a peptic ulcer recurs before the patient has fully recovered from the initial hemorrhage, operation preceded by transfusion should be performed as an emergency procedure for secondary hemorrhage. The majority of surgeons base their treatment of gastric hemorrhage on these principles,
Intermediate-term results of heart-lung transplantation for cystic fibrosis
Authors: B.P. Madden, R. Radley-Smith, A. Khaghani, M.Y. Yacoub, B.P. Madden, M.E. Hodson, V. Tsang, M.Y. Yacoub, B.P. Madden, M.E. Hodson, V. Tsang, A. Khaghani, M.Y. Yacoub
Journal: The Lancet (1992)
Imbalance of T cell subpopulations in peripheral blood of children with non‐Hodgkin malignant lymphoma
Authors: J. D. Beck, N. Wollner, D. R. Miller, R. A. Good, S. Gupta
Journal: American Journal of Hematology (1980)

Abstract Peripheral blood lymphocytes from 13 children with newly diagnosed untreated non‐Hodgkin malignant lymphoma were investigated for the proportion of Tμ and Tγ cells. Tumor involvement was classified as stage II in two patients, stage III in five patients, and stage IV in six patients. Diffuse poorly differentiated lymphoblastic histological‐type lymphomas, as defined by the Rappaport classification, were found in eight patients. The proportion of Tγ cells was found to be increased and that of Tμ cells decreased in the patient group as compared to levels in healthy controls. A marked imbalance of the Tμ/Tγ ratio was observed in ten of 13 patients. There was no correlation between Tμ/Tγ ratios and stage of the disease. Imbalances of Tμ and Tγ cell proportions are discussed in relation to humoral and cellular immunodeficiencies observed in patients with non‐Hodgkin malignant lymphoma.
The mole remains the same
Authors: Jeffrey C McIlwain
Journal: BMJ (2008)

Elwyn’s comment is interesting as an appeal. However, one wonders whether this ideal is a factual elution or a wish list.1 I would like references for his statement that “Consent is often completed a few hours before the intended procedure.” Does he mean the reaffirmation or the primary consent taking process? In hospital, the latter may …
Zebrafish runx1 promoter-EGFP transgenics mark discrete sites of definitive blood progenitors
Authors: Enid Yi Ni Lam, Jackie Y. M. Chau, Maggie L. Kalev-Zylinska, Timothy M. Fountaine, R. Scott Mead, Christopher J. Hall, Philip S. Crosier, Kathryn E. Crosier, Maria Vega Flores
Journal: Blood (2008)
Myocardial Infarction in a Patient with Hypertrophic Cardiomyopathy
Authors: Franca Gori, Cristina Basso, Gaetano Thiene
Journal: New England Journal of Medicine (2000)

18 issue 1 that Dr. Vera Price, the author of a Drug Therapy article published in the September 23 issue, 2 had received major research support through her university from companies that manufactured drugs discussed in her article and that she had recently consulted for those companies.Although she informed us of these arrangements at the time her article was solicited, we failed to respond in accordance with our conflict-ofinterest policy, which would have disqualified her.Because of the inconsistency between our stated policy and practice in this case, we reviewed the files and spoke with the authors of the Drug Therapy articles published since January 1, 1997, to determine whether there were similar inconsistencies.We have now completed our review.We found 18 instances in which one or more authors of Drug Therapy articles received major research support through their institutions from relevant companies or served as consultants for those companies at the time they were invited to prepare their articles.The authors had informed us of these arrangements, and the editors in Boston were aware of them and approved them.
Use of Optical Immunoassay to Diagnose Streptococcal Pharyngitis-Reply
Authors: Robert R. Tanz
Journal: JAMA (1997)

<h3>In Reply.</h3> —Dr Dale and colleagues suggest that the relatively high sensitivity of OIA compared with BAP culture observed in our investigation was more a reflection of the poor quality of BAP culture than of the high quality of OIA. We do not believe this to be the case. The pediatricians' offices that participated in our study were selected because many of these sites had participated in similar research projects, and all had office laboratories that were certified under the Clinical Laboratories Improvement Act. In addition, all received instruction in the proper performance of BAP cultures prior to the study. Therefore, it is reasonable to assume that the quality of BAP culturing in these offices was considerably better than that of the typical physician's office. With placement of the bacitracin disk on the primary BAP culture, as was done in our study, only about half of the specimens with GABHS can be