Clinical Implications of Glucose-6-Phosphate Dehydrogenase Deficiency
Authors: ARNO G. MOTULSKY
Journal: Annals of Internal Medicine (1966)

Editorials1 December 1966Clinical Implications of Glucose-6-Phosphate Dehydrogenase DeficiencyARNO G. MOTULSKY, M.D., GEORGE STAMATOYANNOPOULOS, M.D.ARNO G. MOTULSKY, M.D., GEORGE STAMATOYANNOPOULOS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-6-1329 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical significance of the deficiency of red-cell glucose-6-phosphate dehydrogenase (G-6-PD) was realized when this enzymatic abnormality was found to be the basic lesion responsible for hemolytic reactions precipitated by the antimalarial drug primaquine (1). The introduction of simple diagnostic techniques facilitated clinical and population studies and made clinicians aware of the extent of this abnormality. It is now known that more than 100 million people have G-6-PD deficiency. The anomaly is genetically transmitted as a sex-linked trait. 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Med. 274: 1162, 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ARNO G. MOTULSKY, M.D.; GEORGE STAMATOYANNOPOULOS, M.D.Affiliations: Departments of Medicine (Division of Medical Genetics) and Genetics University of Washington Seattle, Wash. 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M. PHILLIPS, M.D., N. P. SILVERS, M.D.The narcotic addict as a medical patientISONIAZID: HOW MUCH A CARCINOGEN?ERYTHROCYTE ENZYME ACTIVITY IN NEGROESMEASURING PACKED-CELL VOLUME 1 December 1966Volume 65, Issue 6Page: 1329-1334KeywordsAntimalarialsDehydrogenasesDiagnostic techniquesGlucose-6-phosphate dehydrogenase deficiencyLesionsPrimaquine ePublished: 1 December 2008 Issue Published: 1 December 1966 PDF downloadLoading ...