To Stop Osteoarthritis, Fixing Cartilage May Not Be Enough
Authors: Jennifer Fisher Wilson
Journal: Annals of Internal Medicine (2007)

Current Clinical Issues18 September 2007To Stop Osteoarthritis, Fixing Cartilage May Not Be EnoughJennifer Fisher WilsonJennifer Fisher WilsonSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-147-6-200709180-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Fifty years ago, doctors knew little about osteoarthritis except that it damaged the joints and sometimes caused excessive pain. Today, the disease is far better understood—researchers have gained insight into the mechanical, genetic, and biochemical factors underlying osteoarthritis, and many pharmaceutical companies have long-standing programs devoted to the search for ways to prevent or slow the disease. However—notwithstanding the advent of surgery—most people with osteoarthritis today are little better off than those who had it 50 years ago.There is still no way to stop the progress of osteoarthritis once it starts corrupting joints. Treatment is symptomatic, focusing on strategies ...References1. Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am. 2007;89:780-5. [PMID: 17403800] CrossrefMedlineGoogle Scholar2. Felson DT, Kim YJ. The futility of current approaches to chondroprotection. Arthritis Rheum. 2007;56:1378-83. [PMID: 17469094] CrossrefMedlineGoogle Scholar3. Spector TD, Conaghan PG, Buckland-Wright JC, Garnero P, Cline GA, Beary JF, et al. Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]. Arthritis Res Ther. 2005;7:R625-33. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byParacrine Effect of Synovial-Derived Stem Cells on Induced Knee Osteoarthritis in RatsIntra‐Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐Concept Clinical TrialKnee Osteoarthritis Treatment with the KineSpring Knee Implant System: A Report of Two CasesThe KineSpring load absorber implant: rationale, design and biomechanical characterization 18 September 2007Volume 147, Issue 6Page: 437-439KeywordsBoneCartilageDrugsForecastingGenetic diseasesKneesMusclesOsteoarthritisSurgeryTotal hip replacement ePublished: 18 September 2007 Issue Published: 18 September 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...