tbuckley/cabot-search huggingface dataset:
The Natural History of Asymptomatic Carotid Artery Occlusive Lesions
Authors: Irene Meissner
Journal: JAMA (1987)

The purpose of this retrospective study was to determine the long-term prognosis of patients with asymptomatic pressure-significant (hemodynamically significant) internal carotid system lesions. Of 640 neurologically asymptomatic patients, 292 had pressure-significant internal carotid artery occlusive lesions as determined by ocular pneumoplethysmography, while 348 had a carotid bruit only without a pressure-significant lesion. The annual stroke rate for the first three years on a Kaplan-Meier life-table basis was 3.4% and 1.5% in the abnormal and normal ocular pneumoplethysmography groups, respectively, as compared with a rate of 0.5% in a normal age- and sex-matched population. The annual total event rate (transient ischemic attack and stroke) was 5.2% in the abnormal vs 2.3% in the normal group, with 56% of all events ipsilateral to the ocular pneumoplethysmography abnormality. These results indicate that patients with asymptomatic pressure-significant carotid system occlusive lesions are at greater risk for stroke than a normal ocular pneumoplethysmography group (twofold) and a general population (sevenfold). (<i>JAMA</i>1987;258:2704-2707)
Health Care and Medicaid — Weathering the Recession
Authors: Diane Rowland
Journal: New England Journal of Medicine (2009)

These are tough economic times. Since December 2007, the U.S. economy has shed 4.4 million jobs, and as of February, the unemployment rate had risen from 4.9% to 8.1%. Millions of Americans have seen their jobs disappear, incomes decline, and health care coverage become increasingly remote (see line graph). Many have sought public coverage from the states through Medicaid, but Medicaid's ability to fill the gap is becoming increasingly constrained, as state revenues decline and states turn to Washington for help in paying their share of the Medicaid bill. What are the implications of this cycle for families, for providers, and . . .
Skin Pigmentation by Phenindione
Authors: N. H. Silverton
Journal: BMJ (1966)

Skin Pigmentation by Phenindione SIR,-Staining of the skin by drugs of internal use is unusual.A simple mechanism may account for skin pigmentation occurring in a patient on long-term treatment with phenindione (Dindevan).A method of repro- ducing the phenomenon has been discovered.A man aged 47 years sustained a coronary thrombosis with a postero-lateral infarction on 5 March 1965.He was treated with phenin-
Abstract IA2-1: Modeling drug sensitivity and resistance in human tumor-derived cell lines
Authors: Jeffrey Settleman
Journal: Clinical Cancer Research (2010)

Abstract Agccumulating evidence points to the importance of genomic heterogeneity across human tumors as a critical determinant of the variable clinical response to molecularly targeted cancer therapies. We have used cancer cell lines as a model system for examining the relationship between underlying genotypes and sensitivity to candidate anticancer agents. These studies have revealed the utility of large panels of cancer cell lines to capture the genomic heterogeneity of human cancer and to identify clinically relevant genotype- phenotype relationships. These studies have begun to shed light on mechanisms underlying sensitivity as well as de novo and acquired resistance to a variety of small molecule inhibitors. Using this same platform, we have also identified a mechanism of reversible drug tolerance that involves a distinct chromatin state displayed transiently by small subpopulations of cancer cells. This drug-tolerant state can be disrupted by chromatin-modifying agents, potentially yielding a therapeutic opportunity to prevent or delay the development of more stable genetically conferred drug resistance mechanisms. Citation Information: Clin Cancer Res 2010;16(14 Suppl):IA2-1.
Tc-99m DMSA Uptake by Metastatic Colorectal Carcinoma
Authors: Phivi Rondogianni, George Koniaris
Journal: Clinical Nuclear Medicine (2004)

Extrarenal uptake of Tc-99m DMSA is not seen very often. It has previously been described in metastatic disease and was mainly attributed to the presence of V-DMSA in the injected solution. We report a clinical case of incidental visualization of metastatic bone disease of the colon in a patient with renal failure. This could be the result of not only the presence of V-DMSA, but also the renal failure and the atypia of the lesions.
Outcomes and Resource Utilization for Patients with Prolonged Critical Illness Managed by University-based or Community-based Subspecialists
Authors: PETER B. BACH, SHANNON S. CARSON, ALAN LEFF
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

We studied 118 patients with prolonged critical illness to determine if there would be a difference in outcome between patients managed by university-based (UB) or community-based (CB) intensivists. Patients consecutively admitted to a long-term acute care hospital were assigned in an arbitrary manner to the UB service or CB service. Patient survival, length of stay, and success and length of time required for liberation from mechanical ventilation (MV) were compared using survival analysis, logistic regression, and analysis of variance techniques. Patients on the UB service were liberated from MV in 32% fewer days (39 versus 57 d, p = 0.02) and were marginally more likely to be liberated from MV (46% versus 30%, p = 0.14). UB physicians were more likely to write do not resuscitate orders (59% versus 33%, p < 0.01) and to withdraw life-sustaining therapy (12% versus 2%, p = 0.09). There were no detectable differences in survival between the two groups. Estimated reimbursement for CB physicians ($6,797/patient) was 46% greater than for UB physicians ($4,651/patient) for discharged patients (p = 0.03). We conclude that patients experiencing prolonged critical illness may experience different outcomes based on their physician provider. In our study, patients were liberated more quickly from MV, were withdrawn from life support more readily, and were managed at lower cost by UB intensivists than by CB intensivists.
Cardiac Sarcoidosis
Authors: Riina Kandolin, Jukka Lehtonen, Juhani Airaksinen, Tapani Vihinen, Heikki Miettinen, Kari Ylitalo, Kari Kaikkonen, Suvi Tuohinen, Petri Haataja, Tuomas Kerola, Jorma Kokkonen, Markus Pelkonen, Päivi Pietilä-Effati, Seppo Utrianen, Markku Kupari
Journal: Circulation (2014)

This study was designed to assess the epidemiology, characteristics, and outcome of cardiac sarcoidosis (CS) in Finland. We identified in retrospect all adult (>18 years of age) patients diagnosed with histologically confirmed CS in Finland between 1988 and 2012. A total of 110 patients (71 women) 51±9 years of age (mean±SD) were found and followed up for outcome events to the end of 2013. The annual detection rate of CS increased >20-fold during the 25-year period, reaching 0.31 in 1×10(5) adults between 2008 and 2012. The 2012 prevalence of CS was 2.2 in 1×10(5). Nearly two thirds of patients had clinically isolated CS. Altogether, 102 of the 110 patients received immunosuppressive therapy, and 56 received an intracardiac defibrillator. Left ventricular function was impaired (ejection fraction <50%) in 65 patients (59%) at diagnosis and showed no overall change over 12 months of steroid therapy. During follow-up (median, 6.6 years), 10 patients died of a cardiac cause, 11 patients underwent transplantation, and another 11 patients suffered an aborted sudden cardiac death. The Kaplan-Meier estimates for 1-, 5-, and 10-year transplantation-free cardiac survival were 97%, 90%, and 83%, respectively. Heart failure at presentation predicted poor outcome (log-rank P=0.0001) with a 10-year transplantation-free cardiac survival of only 53%. The detection rate of CS has increased markedly in Finland over the last 25 years. With current therapy, the prognosis of CS appears better than generally considered, but patients presenting with heart failure still have poor long-term outcome.
Familial hyperparathyroidism. Medical and surgical considerations
Authors: A. L. Graber
Journal: JAMA (1968)

Hyperparathyroidism occurred in four members of a family, involving two generations. The tendency for involvement of multiple parathyroid glands and for recurrence was prominent, illustrating the necessity for a thorough surgical exploration and a long follow-up. Awareness of the familial syndrome resulted in early treatment of three of the four affected members, possibly avoiding the damaging renal effects of prolonged hypercalcemia.
In Pursuit of the Vector of Kala-azar in Kenya
Authors: R. B. Heisch, D. J. B. Wijers, D. M. Minter
Journal: BMJ (1962)

MMCAL JOURINAX admission to hospital in September, 1958, the 24-hour urinary lead excretion was 110 Ag. and the concentration of lead in the blood was 70 pg./ 100 ml.Like Case 6, this man was first treated with benzylpenicillin by mouth and intramuscularly in doses of 2 mega units.After a 48-hour interval penicillamine was given by mouth-0.5 g. for two days and 1 g. for two days (Table 11).Case 8.-A 50-year-old foundry worker who, when hospitalized in October, 1958, had a 24-hour urinary lead output of 150 pg. and a blood lead reading of only 40 ,ug./ 100 ml.Penicillamine was given by mouth; the dosage was 0.5 g. for two days and then, after a 24-hour interval, 1 g. for two days (Table II).
Will a Policy of Refusing Reimbursement for Health Care–Associated Infections Be a Sufficient Incentive to Drive Improvements?
Authors: Dan Krupka, Warren Sandberg, William Weeks
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
1003-7 Primary Pulmonary Hypertension: Invasive and Noninvasive Monitoring in Patients Receiving Continuous Intravenous Flolan Infusion
Authors: Shelley M. Shapiro, Tiesheng Cao, Matthew A. Romano, Xiaosing J. Beckmann, Ning Qi, Leonard E. Ginzton, Bruce H. Brundage
Journal: Journal of the American College of Cardiology (1995)
Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression
Authors: Guido Veit, Radu G. Avramescu, Doranda Perdomo, Puay-Wah Phuan, Miklos Bagdany, Pirjo M. Apaja, Florence Borot, Daniel Szollosi, Yu-Sheng Wu, Walter E. Finkbeiner, Tamas Hegedus, Alan S. Verkman, Gergely L. Lukacs
Journal: Science Translational Medicine (2014)

Ivacaftor, a potentiator of ΔF508-CFTR channel function in cystic fibrosis, reduces the ability of corrector drugs to rescue the ΔF508-CFTR membrane trafficking defect.
458 Percentage of HCV infected hepatocytes is a better predictive factor of response to the PEG-IFN-α plus ribavirin therapy than serum HCV-RNA concentration
Authors: J. Bartolome, E. Rodriguez-Inigo, J.M. Lapez-Alcorocho, N. Ortiz-Movilla, M. Pardo, P. Rey, V. Carreno
Journal: Journal of Hepatology (2004)
Bone marrow transplantation for good‐risk patients with leukemia in a university affiliated hospital
Authors: Joseph D. Verdirame, James E. Bruckman, John R. Feagler, James R. Commers
Journal: American Journal of Hematology (1986)

Abstract Of the first 14 patients with acute or chronic leukemia to undergo bone marrow transplantation at our hospital, 9 (64%), all good‐risk, are still alive in remission at 18 to 42 months of follow‐up (mean, 29 months) with their Karnofsky performance status between 80% and 100%. The conditioning regimen of fractionated‐dose irradiation and high‐dose chemotherapy eradicated their disease; only two patients relapsed after transplantation. Toxicity was acceptable. Acute graft‐versus‐host disease developed in six patients (43%) (grade I or II in four, grade IV in two) and progressed to chronic graft‐versus‐host disease in four. Viral pneumonitis developed in three patients (21%), but none had idiopathic interstitial pneumonitis. The mean hospital charge was $54,355. These preliminary results suggest that good‐risk patients with acute or chronic leukemia can be treated with bone marrow transplantation in a university affiliated hospital with appropriate staff and support facilities and achieve results comparable to those in research institutions at a competitive cost.
Collateral function modified by glyceryl trinitrate and dipyridamole during coronary occlusion in conscious dogs
Authors: S. NABEYAMA, H. TOMOIKE, K. HISANO, H. SHIMOKAWA, T. INOUE, H. YAMAMOTO, M. NAKAMURA
Journal: Cardiovascular Research (1987)

The effects of glyceryl trinitrate and dipyridamole on induced ischaemia were studied in awake dogs during transient coronary occlusion before and after collateral development. Seventeen dogs were instrumented under sterile conditions with a miniature pressure gauge to measure left ventricular pressure, a cannula for aortic pressure, and pairs of piezoelectric crystals towards the subendocardium of the left ventricle for regional segment length measurements. A hydraulic cuff occluder and Doppler flow probe were placed around the left circumflex coronary artery. Collateral function was increased by repeated 2 min coronary occlusions at 32 min intervals for 2-9 days until regional wall motion returned to preocclusive values, despite the persistence of coronary occlusion. The effects of glyceryl trinitrate and dipyridamole were studied after the initial haemodynamic changes had subsided. Collateral function was quantified by integrating changes in end systolic length of the ischaemic area during coronary occlusion. Before collateral development the end systolic length area was 29.4(2.4) cm X s and was unchanged by glyceryl trinitrate or dipyridamole. After the development of collaterals the end systolic length area decreased from 4.1(1.1) to 2.2(1.0) cm X s (p less than 0.01) after glyceryl trinitrate and increased to 14.9(1.7) cm X s (p less than 0.01) after dipyridamole. Therefore, glyceryl trinitrate acted directly on collaterals and improved the induced ischaemia, whereas dipyridamole exaggerated the regional wall motion abnormality.
A fusion protein of flagellin and ovalbumin suppresses the TH2 response and prevents murine intestinal allergy
Authors: Stefan Schülke, Manja Burggraf, Zoe Waibler, Andrea Wangorsch, Sonja Wolfheimer, Ulrich Kalinke, Stefan Vieths, Masako Toda, Stephan Scheurer
Journal: Journal of Allergy and Clinical Immunology (2011)
Iron-load increases the susceptibility of rat hearts to oxygen reperfusion damage. Protection by the antioxidant (+)-cyanidanol-3 and deferoxamine.
Authors: A M van der Kraaij, L J Mostert, H G van Eijk, J F Koster
Journal: Circulation (1988)

To investigate whether iron is involved in the reperfusion syndrome by aggravating free radical injury, the hearts from iron-loaded and control rats were perfused under normoxic, anoxic, and reperfusion conditions. Normoxic perfusion revealed no change in coronary flow, contractility, or lactate dehydrogenase (LDH) release between these two groups. Under anoxic and reperfusion conditions, however, we found a significant increase of ventricle fibrillation (56% vs. 0%, p less than 0.01, n = 9), a significantly lower recovery of contractility (21 +/- 7.4% vs. 81 +/- 6.6%, mean +/- SEM; p less than 0.001), and a significant increase of LDH release (667 +/- 142 vs. 268 +/- 37 mU LDH/min/g wet wt, mean +/- SEM; p less than 0.05). Administration of either 20 microM of the antioxidant (+)-cyanidanol-3 or 50 microM of the iron-chelator deferoxamine totally prevented the generation of ventricle fibrillation and normalized contractility to control levels in the iron-loaded group. Moreover, 20 microM (+)-cyanidanol-3 significantly lowered LDH release in this period (312 +/- 67 mU), whereas deferoxamine had no protective effect on this LDH release (1,494 +/- 288 mU). Normal hearts appeared to be protected by 20 microM (+)-cyanidanol-3 as well. In this group (n = 6), a significantly higher recovery of contractility (97.1 +/- 3.2% vs. 81 +/- 6.6%, p less than 0.05) and a significantly lower release of LDH (110 +/- 27 vs. 268 +/- 37 mU, p less than 0.05) was found compared with the control group (n = 9). No difference in superoxide dismutase or glutathione peroxidase activity was found between the groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Decreased cardiac beta-adrenergic receptors in deoxycorticosterone-salt and renal hypertensive rats.
Authors: E A Woodcock, J W Funder, C I Johnston
Journal: Circulation Research (1979)

The development of experimental deoxycorticosterone-salt (DOCA-salt) and renal artery clip hypertension in rats is associated with alterations in the sensitivity of the myocardium to adrenergic stimulation. We studied beta-adrenergic receptors and isoproterenol-stimulated adenylate cyclase in myocardial membranes from hypertensive rats to determine whether this altered sensitivity is associated with any change in beta-adrenergic receptors. The specific binding of the beta-adrenergic antagonist, 125I-iodohydroxybenzylpindolol, was used to measure numbers and affinities of receptors in myocardial membrane preparations. Cardiac membranes from both DOCA-salt and renal hypertensive rats showed significantly fewer beta-receptors than did membranes from control, normotensive rats. Receptor affinity remained unchanged. This decrease was from 110 +/- 19 to 49 +/- 5 fmol/mg protein for DOCA-salt hypertension and from 110 +/- 18 to 75 +/- 16 fmol/mg protein for renal artery clip hypertension. Isoproterenol-stimulated adenylate cyclase activity also was lower in membranes from hypertensive rats, whereas basal and fluoride-stimulated activities were unchanged.
Surgical and Allied Malpractice
Authors: George E. Hall
Journal: JAMA (1969)

This is the most ambitious attempt to analyze and explain in one volume the concept of medical malpractice and allied subjects of medicolegal significance that has ever been produced. The organization of the subject matter represents a completely new approach—it even concludes with an Apopemptic! The first two sections explain the basic sources of malpractice, defenses against them, consequences of being sued, the doctor as a defendant and as a witness. Sections 3 and 4 then apply these basics to head and neck procedures, thoracic procedures, abdominal surgery, neuromuscular treatments, and vascular problems; and then to the dermatologist, the internist, the pediatrician, the plastic surgeon, the urologist, the psychiatrist, the anesthesiologist, the laboratory clinician, the dentist, the hospital, the pathologist, the radiologist, and the physician engaged in public health and preventive medicine. Section 5 concentrates on nearly all the remaining areas of the law which involve physicians: agency, fraud and
Morphological and morphometric study of the androgenetic alopecic scalp using two- and three-dimensional analysis comparing regional differences
Authors: J.N. Kim, J.Y. Lee, K.J. Shin, Y.C. Gil, K.S. Koh, W.C. Song
Journal: British Journal of Dermatology (2014)

Androgenetic (male-type) alopecia (AGA) is caused by genetic and androgenetic effects. The progression of baldness results in smaller hair papillae, thinner hair and a shortened hair cycle. Alopecia occurs mainly in the frontal region and, to a lesser extent, in the occipital region.The morphological differences in the hair follicular units between the alopecic frontal scalp and the vertex and occipital regions were compared using cross-sectional histology and three-dimensional reconstruction.Skin specimens were obtained from the frontal, vertex and occipital regions of 24 male human cadavers with fully progressed AGA, and from the frontal region of 32 normal cadaveric scalps. These specimens were fixed, processed using routine histological methods, serially sectioned at a thickness of 10 μm and then stained with Masson's trichrome. The serial sections were reconstructed three-dimensionally using 'Reconstruct' software.The ratios between the numbers of terminal and vellus hairs in the frontal and occipital regions in the AGA scalps were 0·2 : 1 and 3·5 : 1, respectively. Almost all of the hair follicles in the frontal region were vellus hair follicles. The sebaceous gland and arrector pili muscle were larger in the frontal region than in the occipital region.The morphology of the AGA scalp has been characterized. The terminal-to-vellus hair ratio in the occipital (normal) region was different from that in the frontal (alopecic) region. Moreover, sebaceous glands were larger in the frontal alopecic region than in the occipital region. These larger glands may be associated with other dermatological pathologies, such as seborrhoeic dermatitis.
560 DROP-OUT ON THE LIVER TRANSPLANTATION WAITING LIST IN A MELD-BASED ALLOCATION MODEL. MULTICENTRIC STUDY OF CAUSES AND RISK FACTORS
Authors: M. Pleguezuelo, J.M. Benitez, A. Poyato, J.L. Montero Alvarez, P. Lopez-Cillero, J.M. Gomez-Bravo, J.M. Pascasio, J. Santoyo, J.M. Rodrigo, J.A. Ferron, F. Nogueras, C. Diaz-Aunion, M. De la Mata
Journal: Journal of Hepatology (2011)
Characterisation of the excitation-contraction coupling system of the hypothermic myocardium following ischaemia and reperfusion
Authors: M. L HESS, M. F WARNER, A. D ROBBINS, S. CRUTE, L. J GREENFIELD
Journal: Cardiovascular Research (1981)

Journal Article Characterisation of the excitation-contraction coupling system of the hypothermic myocardium following ischaemia and reperfusion Get access MICHAEL L HESS, MICHAEL L HESS * From the Departments of Medicine and Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia *Adress for reprint requests: Michael L Hess, MD, MCV Station, Box 281, Medical College of Virginia, Richmond, VA 23298, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar MARK F WARNER, MARK F WARNER From the Departments of Medicine and Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia Search for other works by this author on: Oxford Academic PubMed Google Scholar ALAN D ROBBINS, ALAN D ROBBINS From the Departments of Medicine and Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia Search for other works by this author on: Oxford Academic PubMed Google Scholar STEVEN CRUTE, STEVEN CRUTE From the Departments of Medicine and Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia Search for other works by this author on: Oxford Academic PubMed Google Scholar LAZAR J GREENFIELD LAZAR J GREENFIELD From the Departments of Medicine and Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 15, Issue 7, July 1981, Pages 390–397, https://doi.org/10.1093/cvr/15.7.390 Published: 01 July 1981