Life-Threatening Water Intoxication During Somatostatin Therapy
Authors: CORNELlS HALMA
Journal: Annals of Internal Medicine (1987)

Brief Reports1 October 1987Life-Threatening Water Intoxication During Somatostatin TherapyCORNELlS HALMA, M. D., JAN B. M. J. JANSEN, M.D., Ph.D., A. ROELOF JANSSENS, M.D., Ph.D., GERRIT GRIFFIOEN, M.D., CORNELIS B. H. W. LAMERS, M.D., Ph.D.CORNELlS HALMA, M. D., JAN B. M. J. JANSEN, M.D., Ph.D., A. ROELOF JANSSENS, M.D., Ph.D., GERRIT GRIFFIOEN, M.D., CORNELIS B. H. W. LAMERS, M.D., Ph.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-4-518 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptShort-term infusion (2 hours) of somatostatin has been shown to reduce urinary volume and free-water clearance in healthy persons (1). Although somatostatin is being widely used (2), water intoxication has not been described as a side effect. We report two cases of marked water retention and hyponatremia that occurred in patients receiving somatostatin therapy (given in continuous intravenous infusion at a rate of 250 μg/h after a loading dose of 250 μg). One patient had to be treated with hypertonic saline for hypo-osmolar coma.Patient 1, a 44-year-old woman with multiple endocrine neoplasia, type 1, had had an insulinoma and...References1. WALKEREVANSFORSLINGNELSTROP BPMG. Somatostatin and water excretion in man: an intrarenal action. Clin Endocrinol. 1985;23:169-74. CrossrefMedlineGoogle Scholar2. MULVIHILLPAPPASPASSARODEBAS STEH. The use of somatostatin and its analogs in the treatment of surgical disorders. Surgery. 1986;100:467-75. MedlineGoogle Scholar3. PRUSZCZYNSKIARDAILLOU WR. Somatostatin and water excretion [Letter]. Lancet. 1983;2:628-9. CrossrefMedlineGoogle Scholar4. BRAUTBARLEVINECOBURNKLEEMAN NBJC. Interaction of somatostatin with PTH and AVP: renal effects. Am J Physiol. 1979;237:E428-36. MedlineGoogle Scholar5. FRIEDLANDERAMIEL GC. Somatostatin and alpha 2-adrenergic agonists selectively inhibit vasopressin-induced cyclic AMP accumulation in MDCK cells. FEBS Lett. 1986;198:38-42. CrossrefMedlineGoogle Scholar6. VORAOWENSRYDERATIEALUZIOHAYES JDRJST. Effect of somatostatin on renal function. Br Med J [Clin Res]. 1986;292:1701-2. CrossrefMedlineGoogle Scholar7. PRICEJAFFEZINNER BBM. The effect of somatostatin on central hemodynamics, renal blood flow, and renal function in dogs. Surgery. 1985;97:285-9. MedlineGoogle Scholar8. CASTELLINOCODADEFRONZO PBR. The effect of intravenous amino acid infusion on renal hemodynamics in humans. Am J Physiol. 1986(1 pt 2)251:F132-40. MedlineGoogle Scholar9. KUROKAWAAPONTEFUJIBAYASHIYAMADA KGST. Somatostatin-like immunoreactivity in the glomerulus of rat kidney. Kidney Int. 1983;24:754-7. CrossrefMedlineGoogle Scholar10. NOLPHSCHRIER KR. Sodium, potassium and water metabolism in the syndrome of inappropriate antidiuretic hormone secretion. Am J Med. 1970;49:534-45. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Gastroenterology and Hepatology University Hospital Leiden Leiden, the Netherlands PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySomatostatin and the "Small-For-Size" LiverSomatostatin analogues in the treatment of endocrine tumours of the gastrointestinal tractThe epidural and intrathecal administration of somatotrophin-release inhibiting factor: Native and synthetic analoguesGastrointestinal endocrine tumours: Medical managementThe biology and practice of surgical drains part IIMicrovillus inclusion diseaseManagement of severe hyponatremia: Rapid or slow correction?Preclinical and clinical studies with somatostatin related to the central nervous system 1 October 1987Volume 107, Issue 4Page: 518-520KeywordsComaHyponatremiaInsulinomaIntoxicationMultiple endocrine neoplasiaSomatostatin ePublished: 1 December 2008 Issue Published: 1 October 1987 PDF downloadLoading ...