tbuckley/cabot-search huggingface dataset:
Reticulum cell sarcoma of the small bowel and steatorrhoea
Authors: D. Eakins, T. Fulton, D. R. Hadden
Journal: Gut (1964)

This series presents further evidence for an association between reticulosis of the intestine and steatorrhoea. Although some patients have a definite past history of gluten enteropathy, it seems likely that in certain patients the reticulosis itself is the primary cause of the steatorrhoea.
Sudden death in a young asthmatic.
Authors: H. Herxheimer
Journal: BMJ (1969)

on publishing the details of a 14-year-old child who died of asthma.Previous reports of death in asthma' ' have laid emphasis on rthe high risk of death in this age group and have indicated that the main cause of death may 'be abuse of pres- surized bronchodilator aerosols.The paper of Gregg and Batten draws attention to the fact that underprescrdption {of steroids may be dangerous, particularly in
Targeted therapy of brain ischaemia using Fas ligand antibody conjugated PEG-lipid nanoparticles
Authors: Ying-mei Lu, Ji-yun Huang, Huan Wang, Xue-fang Lou, Mei-hua Liao, Ling-juan Hong, Rong-rong Tao, Muhammad M. Ahmed, Chun-lei Shan, Xiao-liang Wang, Kohji Fukunaga, Yong-zhong Du, Feng Han
Journal: Biomaterials (2013)
The NHS in the age of anxiety
Authors: T. Jackson
Journal: BMJ (2013)

This year is shaping up to be the NHS's annus horribilis.Sixty five years since it began, the service has been subject to a constant drip of bad news-from Robert Francis's report into what went wrong at Mid Staffordshire NHS Foundation Trust, to the so called crisis in emergency departments.Yet in his essay this week, Rudolf Klein tells us that statistically, there does not seem to be much wrong with the NHS (doi:10.1136/bmj.f5104).Key performance targets have been maintained in the face of fiscal austerity, hospital infection rates have improved, and the service seemed to be making good progress in hitting its savings targets.And the NHS "has successfully implemented" the Lansley reforms, even though, as Kieran Walshe says in his editorial (
Plasma-Volume Determinations in Rheumatic Subjects during Oral Salicylate Therapy
Authors: Charles L. York, William J. H. Fischer
Journal: New England Journal of Medicine (1947)

COBURN'S1 report advocating large doses of salicylates in rheumatic fever aroused widespread interest in the problem of salicylate intoxication. The milder symptoms of nausea, vomiting, tinnitus, deafness and vertigo are considered to be of minor significance. The origin of these symptoms and the action of sodium bicarbonate in alleviating them have been discussed by Smull and her associates2 and Caravati and Cosgrove.3 The more serious toxic complications, including death, delirium, dyspnea, acidosis, hypoprothrombinemia and hemorrhage have been investigated by Ryder et al.,4 Manchester,5 Owen and Bradford6 and Jager and Alway.7 The last investigators suggested the possibility of an increased plasma . . .
Somatostatin analogues reduce liver volume in polycystic liver disease
Authors: L van Keimpema, R A de Man, J P H Drenth
Journal: Gut (2008)

Polycystic livers occur in the setting of two inherited conditions: (1) autosomal dominant polycystic kidney disease (ADPKD), also characterised by progressive development of renal cysts resulting in loss of renal function, and (2) polycystic liver disease (PCLD), with a polycystic liver as the sole manifestation. Symptoms, such as abdominal distension, result from hepatomegaly. Ascites is a rare complication and might be due to portal hypertension or caused by a ruptured cyst.

Treatment strategies for polycystic livers are aimed at reducing liver volume. So far, only surgical options are available, but these are associated by considerable morbidity and mortality.1 Alternatively, ascites in the setting of polycystic livers might respond to endovascular stent placement in the narrowed caval vein,2 but medical options are conspicuously lacking so far. We wish to report two cases with severe polycystic liver …
Amylmetacresol and 2, 4-dichlorobenzyl alcohol lozenges were better than placebo lozenges for relief of acute sore throat
Authors: Michael J. Thomas
Journal: Annals of Internal Medicine (2010)

Source Citation McNally D, Simpson M, Morris C, Shephard A, Goulder M. Rapid relief of acute sore throat with AMC/DCBA throat lozenges: randomised controlled trial. Int J Clin Pract. 2010;64:194-207. 19849767
CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions
Authors: Amir Schajnovitz, Tomer Itkin, Gabriele D'Uva, Alexander Kalinkovich, Karin Golan, Aya Ludin, Dror Cohen, Ziv Shulman, Abraham Avigdor, Arnon Nagler, Orit Kollet, Rony Seger, Tsvee Lapidot
Journal: Nature Immunology (2011)
Mind the Gap: Disparity Between Research Funding and Costs of Care for Diabetic Foot Ulcers
Authors: David G. Armstrong, Vikram A. Kanda, Lawrence A. Lavery, William Marston, Joseph L. Mills, Andrew J.M. Boulton
Journal: Diabetes Care (2013)

Diabetic foot ulceration (DFU) is a serious and prevalent complication of diabetes, ultimately affecting some 25% of those living with the disease (1). DFUs have a consistently negative impact on quality of life and productivity as diabetic patients report stigma, social isolation, unemployment, and depression (2–5). Patients with DFUs also have morbidity and mortality rates equivalent to aggressive forms of cancer (2). These ulcers remain an important risk factor for lower-extremity amputation as up to 85% of amputations are preceded by foot ulcers (6). It should therefore come as no surprise that some 33% of the $116 billion in direct costs generated by the treatment of diabetes and its complications was linked to the treatment of foot ulcers (7). Another study has suggested that 25–50% of the costs related to inpatient diabetes care may be directly related to DFUs (2).

National standards have been developed for DFU prevention and care (8–10). Given the high prevalence, severity, costs, and morbidity of diabetic foot complications, one would expect that federal funding for DFU research would be proportionate to its public health impact. The National Institutes of Health (NIH) is the major source of federal funding for medical research in the U.S. We therefore examined NIH funding for both diabetes and DFUs using the NIH Research Portfolio Online Reporting Tools (RePORT) from 2002 to 2011 (11). We also examined differences in the number of peer-reviewed publications (using PubMed at www.ncbi.nlm.nih.gov) on both diabetes and diabetic foot ulcers between the years 1980–2010. The search terms …
Surgeon who removed ovary by mistake is allowed to continue practising
Authors: C. Dyer
Journal: BMJ (2014)

A registrar who removed a healthy ovary from a pregnant woman with appendicitis instead of her appendix has been allowed to continue practising, after a Medical Practitioners Tribunal Service panel decided that he was “not a danger to the public.”

Yahya Al-Abed was “out of his depth” in performing the operation on Maria de Jesus at Queen’s Hospital in Romford, Essex, on 23 October 2011, the panel found. A consultant surgeon, Babatunde Coker, should have performed it or at least supervised it but had gone home.

De Jesus gave birth to a stillborn boy and …
Herpetic Encephalitis and Acute Retinal Necrosis
Authors: Peter W Hadden, Christopher J Barry
Journal: New England Journal of Medicine (2002)

Figure 1. A 45-year-old man with a biopsy-proven pineal tumor was on the seventh day of his first cycle of chemotherapy when symptoms of meningeal irritation and confusion developed. Polymerase chain reaction of cerebrospinal fluid revealed herpes simplex virus type 2, and after acyclovir treatment he appeared to make a complete recovery. However, during his third cycle of chemotherapy, he had severe visual loss, and the diagnosis of bilateral acute retinal necrosis was made. Despite therapy, retinal detachment and ischemic optic neuropathy ensued, and the patient was left with no light perception bilaterally.
Terminology of Coal Miners' Pneumoconiosis
Authors: Charles E. Andrews
Journal: JAMA (1972)

To the Editor.—  For many years an appreciation of the clinical and pathophysiologic derangements that occur in chronic obstructive airway disease was hampered because of the problems with semantics and language. With the increased frequency of international meetings, it became evident that standardization of terms was essential, and various organizations including the World Health Organization and American Thoracic Society saw fit to introduce definitions which have since become widely accepted. It is, therefore, with dismay that we read Dr. Naeye's and Mr. Dellinger's paper on  workers'  (CWP) (220:223, 1972). We do not dispute his findings, but cannot but object to use of the term coal workers' pneumoconiosis to include any type of respiratory impairment that occurs in a miner, whether occupationally related or not. The International Labor Organization has defined CWP and throughout the world this condition is taken to mean a disease that is produced by
Cost Effectiveness of Continued-Warfarin Versus Heparin-Bridging Therapy During Pacemaker and Defibrillator Surgery
Authors: Doug Coyle, Kathryn Coyle, Vidal Essebag, David H. Birnie, Kamran Ahmad, Satish Toal, John Sapp, Jeffrey S. Healey, Atul Verma, George Wells, Andrew D. Krahn
Journal: Journal of the American College of Cardiology (2015)
Low-dose HBIG and higher-dose lamivudine combination to prevent post-olt HBV recurrence
Authors: Z. Karasu, A. Celebi, C. Arikan, Y. Tokat, T. Ozacar, M. Kilic, T. Demirbas, S. Acarsoy, U.S. Akarca, E. Galip, F. Gunsar, Y. Batur
Journal: Journal of Hepatology (2003)
The locus <i>C11orf30</i> increases susceptibility to poly‐sensitization
Authors: A. F. S. Amaral, C. Minelli, S. Guerra, M. Wjst, N. Probst‐Hensch, I. Pin, C. Svanes, C. Janson, J. Heinrich, D. L. Jarvis
Journal: Allergy (2014)

A number of genetic variants have been associated with allergic sensitization, but whether these are allergen specific or increase susceptibility to poly-sensitization is unknown. Using data from the large multicentre population-based European Community Respiratory Health Survey, we assessed the association between 10 loci and specific IgE and skin prick tests to individual allergens and poly-sensitization. We found that the 10 loci associate with sensitization to different allergens in a nonspecific manner and that one in particular, C11orf30-rs2155219, doubles the risk of poly-sensitization (specific IgE/4 allergens: OR = 1.81, 95% CI 0.80-4.24; skin prick test/4+ allergens: OR = 2.27, 95% CI 1.34-3.95). The association of rs2155219 with higher levels of expression of C11orf30, which may be involved in transcription repression of interferon-stimulated genes, and its association with sensitization to multiple allergens suggest that this locus is highly relevant for atopy.
Chromium-induced diffuse dermatitis with lymph node involvement resulting from Langerhans cell histiocytosis after metal-on-metal hip resurfacing
Authors: N. Bizzotto, A. Sandri, G. Trivellin, B. Magnan, G.M. Micheloni, A. Zamò, P. Bernardi, A. Sbarbati, D. Regis
Journal: British Journal of Dermatology (2014)

Total hip arthroplasty (THA) is a highly effective surgical treatment for severe joint involvement. However, due to the release of metal ions in the blood, the patients who undergo hip replacement with metal-on-metal (MOM) bearings may develop signs of allergic skin disease. We report a case of a 60-year-old man who had received MOM hip resurfacing 5 years earlier for osteoarthritis. He presented with a 3-year history of diffuse dermatitis that did not respond to antihistamines and corticosteroids and also had elevated serum levels of chromium and cobalt. A patch test revealed chromium-sulfate hypersensitivity. A skin biopsy showed nonspecific perivascular lymphocytic infiltrate associated with histiocytes. A biopsy of an inguinal lymph node demonstrated large aggregates of Langerhans cells, suggesting type IV delayed-type hypersensitivity. The prosthesis was replaced using ceramic-on-ceramic bearings and the dermatitis resolved after 3 months. The lymph nodes decreased in volume and the serum chromium levels normalized within 24 months of revision surgery. The high levels of serum ions associated with the metal debris from MOM-THAs may induce sensitization and type IV hypersensitivity reactions. Replacing the prosthesis using alternative coupling surfaces is the only approach that has the capacity to resolve these symptoms. Physicians who are not familiar with this issue may misdiagnose systemic symptoms and provide inadequate treatment.
5-Fluorouracil-Reply
Authors: John H. Talbott
Journal: JAMA (1962)

I am pleased to acknowledge Dr. Morris' letter questioning our editorial scanning. It should be noted for the record that I review each manuscript upon its receipt in this office. It is then sent out by a member of the staff for review to one or more experts. I sit in final judgment for rejection, acceptance, or revision. I do not believe there is any laxity in editorial industry. Editorial judgment, however, is something for each reader to decide.
Re: Renaud Bollens, Dimitri Mikhaski, Baldo P. Espinoza, Alberto Rosenblatt, Anh Dung Hoang, Daniel Abramowicz, Vincent Donckier and Claude Schulman. Laparoscopic Live Donor Right Nephrectomy: A New Technique to Maximize the Length of the Renal Vein Using a Modified Endo GIA Stapler? Eur Urol 2007;51:1326–31
Authors: Serdar Deger, Markus Giessing
Journal: European Urology (2007)
Ontogeny, evolution, and folk psychology
Authors: Daniel J. Povinelli, Mia C. Zebouni, Christopher G. Prince
Journal: Behavioral and Brain Sciences (1996)

Abstract Barresi &amp; Moore assume an equivalence between ontogenetic and evolutionaiy transformations of social understanding. The mechanisms of evolution allow for novel structures to arise, both through terminal addition and through the onset of novel pathways at time points that precede the end points of ancestral pathways. Terminal addition may not be the appropriate model for the evolution of human object-directed imitation, intermodal equivalence, or joint attention.
Characteristics of vascular hydraulic load in patients with heart failure.
Authors: W K Laskey, W G Kussmaul, J L Martin, J P Kleaveland, J W Hirshfeld, S Shroff
Journal: Circulation (1985)

Aortic input impedance and hydraulic power were derived from simultaneous catheter recordings of ascending aortic pressure and velocity in eight normal subjects and 11 age-matched subjects with clinical heart failure secondary to idiopathic congestive cardiomyopathy. Resting data revealed the characteristic depression of cardiac output and elevation of systemic vascular resistance in patients with heart failure. The pulsatile component of vascular hydraulic load, characteristic impedance (Zc), was similar in both groups (Zc normal: 85 +/- 30 dyne-sec-cm-5; Zc cardiomyopathy: 93 +/- 33 dyne-sec-cm-5). The oscillatory fraction of aortic input power in patients with heart failure (14 +/- 4%) was also similar to that of normal subjects (11 +/- 2%). The transition from rest to exercise in patients with heart failure was marked by a decrease in the steady component of arterial hydraulic load, although characteristic impedance did not change. A similar qualitative response occurred in normal subjects, although the systemic vascular resistance during exercise remained above normal in patients with heart failure. The modulus of the first harmonic of impedance significantly decreased during exercise in normal subjects but did not change significantly in patients with heart failure. Furthermore, the modulus of the first harmonic of the reflection coefficient decreased significantly during exercise in normal subjects but did not change in patients with heart failure in spite of systemic vasodilation. Exercise appears to impose no additional increase in vascular hydraulic load on the ejecting left ventricle. The similar aortic characteristic impedances in patients with heart failure and in normal subjects, at rest and during exercise, are consistent with a constant oscillatory fraction of input power.
Structure-Function Relationships during Granulosa Cell Differentiation*
Authors: ABRAHAM AMSTERDAM, SIEGFRIED ROTMENSCH
Journal: Endocrine Reviews (1987)

THE CYCLIC nature of the female reproductive process is largely dependent upon the unique capability of the ovarian follicle to change in structure and function. A finely tuned process of differentiation occurs in all constituents of the follicle during folliculogenesis. Granulosa cells (GCs) display a high degree of structural change and play a key role in the functional maturation of the entire follicle. These changes in response to endocrine and paracrine stimuli create the unique environment for oocyte growth and ovulation by virtue of their biochemical activity and intimate anatomical relationship. Moreover, the maintenance of early pregnancy depends on transformation of GCs into highly differentiated luteal cells (for review see Refs. 1–3). Our understanding of GC maturation and luteinization has substantially improved in the last 15 yr largely due to the extensive use of the cell culture approach. In vitro induction of differentiation in serum-free media allowed for identification of the molecular factors involved (for review see Ref. 4).
Longitudinal relationship between physical activity and lung health in patients with cystic fibrosis
Authors: Jane E. Schneiderman, Donna L. Wilkes, Eshetu G. Atenafu, Thanh Nguyen, Greg D. Wells, Nancy Alarie, Elizabeth Tullis, Larry C. Lands, Allan L. Coates, Mary Corey, Felix Ratjen
Journal: European Respiratory Journal (2013)

Exercise is beneficial for patients with cystic fibrosis (CF) but long-term effects of physical activity on lung function evolution are unknown. We evaluated the longitudinal relationship between changes in habitual physical activity (HPA) and rate of decline in lung function in patients with CF. We tracked HPA using the Habitual Activity Estimation Scale, forced expiratory volume in 1 s (FEV 1 ) and Stage I exercise tests in 212 patients with CF over a 9-year period. Adjusting for sex, baseline age and FEV 1 , mucoid Pseudomonas aeruginosa and CF-related diabetes, mean± sd FEV 1 % predicted decreased by 1.63±0.08% per year (p&lt;0.0001) while mean± sd HPA increased by 0.28±0.03 h·day −1 per year (p&lt;0.0001) over the study period. A greater increase in HPA was associated with a slower rate of decline in FEV 1 (r=0.19, p&lt;0.0069). Dividing subjects into “high” and “low” activity (above or below the mean rate of change of activity, respectively), a steeper rate of FEV 1 decline was observed for low (-1.90% per year) compared to high (-1.39% per year) (p=0.002). Increases in HPA are feasible despite progression of lung disease and are associated with a slower rate of decline in FEV 1 , highlighting the benefit of regular physical activity, and its positive impact on lung function in patients with CF.
Alternative Medicine: A Mirror Image for Scientific Medicine
Authors: Edzard Ernst
Journal: Annals of Internal Medicine (2002)

Letters17 September 2002Alternative Medicine: A Mirror Image for Scientific MedicineEdzard Ernst, MD, PhD, FRCP(Edin)Edzard Ernst, MD, PhD, FRCP(Edin)University of Exeter; Exeter EX2 4NT, United KingdomSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-6-200209170-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Vandenbroucke and de Craen should be congratulated for writing a stimulating article on medical thinking in general (1). I fear, however, that they may have gotten some of their specifics wrong when stating that homeopathy is supported by “seemingly solid evidence” (1). Vandenbroucke and de Craen base this statement on a meta-analysis by Linde and colleagues (2). However, several subsequent attempts (3, 4) to reanalyze Linde and colleagues' data set have cast considerable doubt on their positive conclusions. Most impressive, perhaps, Linde and colleagues themselves reanalyzed their data and concluded that “there was clear evidence that studies ...References1. Vandenbroucke JP, de Craen AJ. Alternative medicine: a “mirror image” for scientific reasoning in conventional medicine. Ann Intern Med. 2001;135:507-13. [PMID: 11578154] LinkGoogle Scholar2. Linde K, Clausius N, Ramirez G, Melchart D, Eitel F, Hedges LV, et al . Are the clinical effects of homeopathy placebo effects? A meta-analysis of placebo-controlled trials. Lancet. 1997;350:834-43. [PMID: 9310601] CrossrefMedlineGoogle Scholar3. Ernst E. Are highly dilute homoeopathic remedies placebos? Perfusion. 1998;11:291-2. Google Scholar4. Ernst E, Pittler MH. Re-analysis of previous meta-analysis of clinical trials of homeopathy [Letter]. J Clin Epidemiol. 2000;53:1188. [PMID: 11186614] CrossrefMedlineGoogle Scholar5. Linde K, Scholz M, Ramirez G, Clausius N, Melchart D, Jonas WB. Impact of study quality on outcome in placebo-controlled trials of homeopathy. J Clin Epidemiol. 1999;52:631-6. [PMID: 10391656] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: University of Exeter; Exeter EX2 4NT, United Kingdom PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAlternative Medicine: A “Mirror Image” for Scientific Reasoning in Conventional Medicine Jan P. Vandenbroucke and Anton J.M. de Craen Alternative Medicine: A Mirror Image for Scientific Medicine Jan P. Vandenbroucke and Anton J.M. de Craen Metrics 17 September 2002Volume 137, Issue 6Page: 546KeywordsFearHomeopathy ePublished: 17 September 2002 Issue Published: 17 September 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
1043-50 The extent of coronary atherosclerosic determined by angioscopy is a risk factor of restenosis
Authors: Yasunori Ueda, Isamu Mizote, Tomohito Ohtani, Masaya Usami, Takashi Oka, Astushi Hirayama, Kazuhisa Kodama
Journal: Journal of the American College of Cardiology (2004)
Darier's sign associated with non-Hodgkin's lymphoma
Authors: F.M. LEWIS, G.B. COLVER, D.N. SLATER
Journal: British Journal of Dermatology (1994)

Journal Article Darier's sign associated with non‐Hodgkin's lymphoma Get access F.M. LEWIS, F.M. LEWIS Department of Dermatology, Royal Hallamshire Hospital, Sheffield Search for other works by this author on: Oxford Academic Google Scholar G.B. COLVER, G.B. COLVER Department of Dermatology, Royal Hospital, Chesterfield, U.K. Search for other works by this author on: Oxford Academic Google Scholar D.N. SLATER D.N. SLATER Department of Histopathology, Rotherham General Hospital Rotherham, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 130, Issue 1, 1 January 1994, Pages 126–127, https://doi.org/10.1111/j.1365-2133.1994.tb06900.x Published: 01 January 1994