tbuckley/cabot-search huggingface dataset:
Abstract 2426: Exacerbation of oxidative DNA damage as a synthetic lethal approach in mismatch repair deficient tumors
Authors: Yari Fontebasso, Madeleine Hewish, Chris J. Lord, Alan Ashworth
Journal: Cancer Research (2014)

Abstract The post-replicative DNA mismatch repair (MMR) pathway plays a key role in the maintenance of genomic stability. MMR corrects mismatches within the DNA helix that arise due to errors in nucleotide incorporation during either semi-conservative replication or synthesis associated with DNA repair. The importance of this system is testified by the fact that mutations affecting components of this repair pathway cause a “mutator” phenotype and predisposition to a wide variety of malignancies including colorectal, gastric, endometrial, and urothelial cancers. For example, the hereditable disorder Lynch syndrome (hereditary nonpolyposis colon cancer) is associated with germline loss of function mutations in the MMR tumor suppressor genes MLH1, MSH2, PMS2, and MSH6. In addition to this familial syndrome, MMR deficiency is present in 15% to 17% of all colorectal cancer cases. Synthetic lethal relationships have been identified that involve specific MMR genes, suggesting that synthetic lethal treatments could be applied to MMR deficient tumors. Previously, efforts to functionally identify genetic DNA mismatch repair synthetic lethalities and potential therapeutic targets have focused on the analysis of either candidate genes or relatively small gene subsets such as protein kinases. In order to define additional SL targets in MMR-deficient genetic backgrounds, we describe here the application of an shRNA screen in matched isogenic dMMR/pMMR (MMR-deficient/MMR-proficient) model cell lines. Using this screening approach, we identify new synthetic lethal interactions between MMR deficiency and components of the base excision repair and of the nucleotide sanitization systems, which restrict the extent of oxidative DNA damage. We propose that inhibition of the processes that minimize the oxidized DNA load could constitute a promising therapeutic approach in mismatch repair deficient cancers. Citation Format: Yari Fontebasso, Madeleine Hewish, Chris J. Lord, Alan Ashworth. Exacerbation of oxidative DNA damage as a synthetic lethal approach in mismatch repair deficient tumors. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2426. doi:10.1158/1538-7445.AM2014-2426
40 BIOSAFETY IN EX VIVO GENE THERAPY AND CONDITIONAL ABLATION OF LENTIVIRALLY- TRANSDUCED HEPATOCYTES IN NON-HUMAN PRIMATES
Authors: O. Menzel, J. Birraux, B. Wildhaber, C. Jond, F. Lasne, W. Habre, T. Nguyen, C. Chardot
Journal: Journal of Hepatology (2009)
A randomized trial of the impact of strict glycaemic control on myocardial diastolic function and perfusion reserve: a report from the DADD (Diabetes mellitus And Diastolic Dysfunction) study
Authors: Christina Jarnert, Lena Landstedt‐Hallin, Klas Malmberg, Anders Melcher, John Ohrvik, Hans Persson, Lars Rydén
Journal: European Journal of Heart Failure (2009)
Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction
Authors: Yong Xu, Thekkethil P. Nedungadi, Liangru Zhu, Nasim Sobhani, Boman G. Irani, Kathryn E. Davis, Xiaorui Zhang, Fang Zou, Lana M. Gent, Lisa D. Hahner, Sohaib A. Khan, Carol F. Elias, Joel K. Elmquist, Deborah J. Clegg
Journal: Cell Metabolism (2011)
Surgical management of native valve endocarditis.
Authors: T Raychaudhury, A Faichney, E W Cameron, P R Walbaum
Journal: Thorax (1983)

From 1972 to 1981 40 patients have required urgent valve replacement for left-sided bacterial endocarditis. The aortic valve was replaced in 31 patients, the mitral valve in four, and both in five patients. Twenty-six patients (65.5%) were in functional class IV heart failure according to the New York Heart Association criteria, and 13 patients (32.5%) were in class III heart failure at the time of operation. One patient in class II was operated on urgently for multiple cerebral embolism but died of fatal cerebral haemorrhage. In 22 patients (55%) there were no pre-existing valvular lesions and these patients were found to be more liable to develop severe haemodynamic failure. Premature closure of the mitral valve, documented by M-mode echocardiography, was a useful diagnostic aid and successfully determined the best timing of surgery in 14 out of 20 patients with severe aortic regurgitation. Cardiac arrest before operation appeared to be a significant risk factor (p = 0.0015) unless followed by immediate cardiopulmonary bypass. There were eight operative deaths (20%). Of 26 patients who were in functional class IV heart failure, 19 were operated on within four days of their haemodynamic deterioration and all survived. The operation was delayed in the remaining seven patients and none of them survived (p = 0.000003). There were no operative deaths among the patients in class III heart failure. There was only one episode of reinfection in the 16 patients followed up for at least three years. The duration of postoperative antibiotic treatment (four to six weeks in our patients), rather than any preoperative antibiotic regimen, seems to be important for preventing reinfection. At present there are 28 survivors, of whom 24 are in functional class I and four in class II.
Primary Care Physicians and Posttraumatic Stress Disorder
Authors: Tom Jefferson
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE TREATMENT OF ALCOHOLIC INEBRIETY.Read before the Northwestern Medical and Surgical Association, March 18, 1893, and before the American Association for the Study and Cure of Inebriety, March 23, 1893.
Authors: FREDERICK PETERSON
Journal: JAMA (1893)

The carpets should be taken up and cleaned at least once a year, and floors scrubbed.Drawers, book¬ cases and closets should also be renovated.Sul¬ phate of iron, Labarraque's solution of soda or chloride of lime may be used to disinfect the cellar when necessary.
Are Medicaid Reforms on the Horizon?
Authors: Rebecca Voelker
Journal: JAMA (1997)

POLICY ANALYSTS have some good news and some bad news on the Medicaid front. First, the good news. For the first time in many years, the increase in spending for the state-federal health care program for the poor has slowed to single digits and projections indicate that spending increases will stay low for the next 5 years. In a recent report sponsored by the Kaiser Commission on the Future of Medicaid, analysts from the Urban Institute in Washington, DC, say Medicaid spending rose by 3.2% in 1996 and by an average of 9.5% annually from 1992 to 1995. From now until 2002, they project annual spending increases to be about 7.5%. "There's no good reason to think it will grow like it has in the past," said John Holahan, PhD, director of health policy research at the Urban Institute and an author of the report. But there's a cloud surrounding
Survival of Cephalothin-Treated Erythrocytes
Authors: Soldano Ferrone, Girolamo Sirchia
Journal: JAMA (1968)

To the Editor:—  Alter et al 1 have written that the interpretation by Nesmith and Davis 2 about survival of cephalothin-treated erythrocytes in patients with antipenicillin antibodies is open to question, since the latter provide no data on the survival of cephalothin-treated erythrocytes in normal individuals without antipenicillin antibodies.  In vitro treatment of autologous blood with cephalothin sodium does not affect the red cell survival in normal subjects; in fact in two healthy males we have observed that the autologous blood, incubated in vitro at 37 C in a water bath for three hours with cephalothin (final concentration 20 mg/ml) and then labelled with 51 Cr, had a normal in vivo survival.  Therefore, we think that Nesmith and Davis 2 are right when they assume that the reduced survival of cephalothin-treated red cells, injected in patients with antipenicillin antibodies, is the effect of the hemolytic action of these antibodies.
Lack of Evidence for Recommended Low-Density Lipoprotein Cholesterol Treatment Targets
Authors: Rodney A. Hayward
Journal: Annals of Internal Medicine (2007)

Letters17 April 2007Lack of Evidence for Recommended Low-Density Lipoprotein Cholesterol Treatment TargetsRodney A. Hayward, MDRodney A. Hayward, MDFrom Veteran Affairs Ann Arbor Healthcare System and University of Michigan, Ann Arbor, Michigan.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-146-8-200704170-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE: I agree with Dr. Modest that considerable evidence suggests that HDL cholesterol level is an important risk factor in predicting cardiovascular risk, but I disagree that it was a “glaring omission” in our paper. Space constraints prevented us from discussing details of each cardiovascular risk factor, but our paper highlighted the critical importance of overall cardiovascular risk, mentioned the complexities of risk factor interactions, and included references that discuss HDL cholesterol effects in detail (1, 2). However, although we agree that HDL cholesterol level is an important independent risk factor, we could find no clinical evidence meeting our ...References1. Nam BH, Kannel WB, D'Agostino RB. Search for an optimal atherogenic lipid risk profile: from the Framingham Study. Am J Cardiol. 2006;97:372-5. [PMID: 16442398] CrossrefMedlineGoogle Scholar2. Olsson AG, Schwartz GG, Szarek M, Sasiela WJ, Ezekowitz MD, Ganz P, et al. High-density lipoprotein, but not low-density lipoprotein cholesterol levels influence short-term prognosis after acute coronary syndrome: results from the MIRACL trial. Eur Heart J. 2005;26:890-6. [PMID: 15764620] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Veteran Affairs Ann Arbor Healthcare System and University of Michigan, Ann Arbor, Michigan.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoNarrative Review: Lack of Evidence for Recommended Low-Density Lipoprotein Treatment Targets: A Solvable Problem Rodney A. Hayward , Timothy P. Hofer , and Sandeep Vijan Lack of Evidence for Recommended Low-Density Lipoprotein Cholesterol Treatment Targets Uffe Ravnskov Lack of Evidence for Recommended Low-Density Lipoprotein Cholesterol Treatment Targets Geoffrey A. Modest Metrics 17 April 2007Volume 146, Issue 8Page: 614-615KeywordsCardiovascular therapyCholesterolClinical epidemiologyClinical trialsConflicts of interestForecastingMedical risk factorsStatins ePublished: 17 April 2007 Issue Published: 17 April 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Passive stiffness of isolated cardiac and skeletal myocytes in the hamster.
Authors: D Fish, J Orenstein, S Bloom
Journal: Circulation Research (1984)

Single cardiac myocytes and skeletal myocyte fragments, devoid of interstitial collagen but with intact glycocalyx, were prepared by mechanical disaggregation of hamster ventricular myocardium and caudal gracilis muscle, respectively. Passive stiffness was studied by examining the sarcomere length-tension relationship over the approximate Eulerian stress range of 0-20 mN/mm2 for cardiac myocytes and 0-120 mN/mm2 for skeletal myocytes. Creep and stress-relaxation became apparent only when cells were stretched to sarcomere lengths close to, or exceeding, 2.2 micron for the cardiac myocytes, and 2.7 micron for the skeletal myocytes. Stress-relaxation and creep occurred simultaneously, suggesting that the sarcomere is at least one of the structural components responsible for viscoelasticity. The differential strain stiffness constant was calculated from the regression of natural stress [Ln(mN/mm2)] against differential strain [(L-Lo)/Lo] and found to be 7.48 +/- 1.73 for the ventricular myocytes and 5.77 +/- 0.87 for the skeletal myocyte fragments. The natural strain stiffness constant was obtained from the regression of natural stress against natural strain [Ln(L/Lo)]. The natural strain stiffness constant was 30-50% higher than the differential strain constant. The high correlation coefficients obtained for both regressions indicate that the length-tension relationships for these isolated cardiac and skeletal myocytes can be very closely fitted to the single exponential function, sigma = C X exp[K(epsilon)]. The length-tension curves obtained for the skeletal myocyte fragments are qualitatively and quantitatively similar to those obtained by others with intact skeletal muscle. The cardiac myocyte length-tension curves are qualitatively, but not quantitatively, similar to those obtained with cardiac muscle. Isolated ventricular myocytes are stiffer than similarly isolated skeletal myocytes. These findings suggest that cellular structures contribute to myocardial stiffness in the hamster.
Immunolocalization of G(alpha)i-3 in foetal lung fibroblasts
Authors: A Dosanjh
Journal: European Respiratory Journal (1998)

Guanosine triphosphate (GTP)-binding proteins or G proteins are involved in a wide variety of well-recognized signalling activities between cell surface receptors and effectors. The heterotrimeric G proteins have alpha,beta and gamma subunits organized in a trimeric structure. The aim of this study was to localize G(alpha)i-3, an important heterotrimeric G protein, in foetal lung cells. Using a foetal lung fibroblast cell line (RFL-6), the localization of G(alpha)i-3 was determined by immunofluorescence using a specific antibody to G(alpha)i-3, colocalization with a lectin known to bind the Golgi complex and Western blotting of RFL-6 cellular membrane proteins. This study identified G(alpha)i-3 on the Golgi membranes in rat foetal lung cells. Treatment with cycloheximide, to block protein synthesis, diminished the cytosolic distribution of the protein, but intense Golgi staining remained. G(alpha)i-3, therefore, appears to be part of the Golgi complex and not present transiently during protein synthesis. In the nonpolar foetal lung fibroblasts studied, the intracellular concentration of G(alpha)i-3 suggests a role for this protein in the intracellular trafficking and regulation of proteins needed for normal lung development.
Peripheral Neuropathy in Two Workers Exposed to 1,1,1-Trichloroethane
Authors: Gary M. Liss
Journal: JAMA (1988)

<h3>To the Editor.—</h3> Two cases of peripheral neuropathy in workers exposed to the solvent 1,1,1-trichloroethane are reported. It was not possible, however, to link them causally with the exposure. Both women worked at degreasing motor end shields in a company that manufactures motors for appliances. This required repeated immersion of their hands into the solvent for several hours at a time. <h3>Report of Cases.—</h3> Case1.—A 25-year-old woman presented to a neurologist in June 1980 with two months of numbness and disturbance of sensation in all limbs beginning three months after starting degreasing. She had worked for six years previously in other departments without problems. The neurologist found hypoactive reflexes and minimal blunting of sensation in the right hand. Nerve-conduction studies in 1980 revealed low median and ulnar sensory action potential amplitudes with normal distal sensory latency and motor conduction velocity; distal sensory latencies were found to be prolonged in
Eastern Equine Encephalitis in Massachusetts — First Human Case in 14 Years
Authors: Lawrence P. Levitt, Frederick H. Lovejoy, Joan B. Daniels
Journal: New England Journal of Medicine (1971)

IN 1957 Feemster1 reviewed the history of human eastern equine encephalitis in Massachusetts. He noted that the first human case was recognized here in 1938 and that there had been a total of 50 cases through 1957. The 50 cases had occurred in three epidemics: 34 in 1938; four in 1955; and 12 in 1956. No cases have been reported since then.Case ReportJ.S. (C.H.M.C.. 72 03 91), a 5-month-old boy, was admitted to Children's Hospital on August 24, 1970, because of seizures. He had been well until 2 days previously, when lethargy, anorexia and fever developed. On the . . .
Superior Vena Cava Obstruction with Intrahepatic and Systemic–Pulmonary Venous Right-to-Left Shunts
Authors: Ba D. Nguyen, Michael C. Roarke
Journal: Clinical Nuclear Medicine (2004)

The diagnosis of superior vena cava obstruction is based on demonstration of venous collateral circulation. Computed tomography (CT) is the best imaging modality for this disease. Nuclear medicine is also helpful in showing caval flow compromise through scintigraphic venography and abnormal radiotracer accumulation from developed venous collaterals. The authors present a case of superior vena cava obstruction with the two less common venous collateral pathways described in the imaging literature: intrahepatic and right-to-left shunts. These shunts are demonstrated by technetium-99m MAA lung scintigraphy with CT and venographic correlation. Characteristics of these two shunts are discussed with a brief review of the literature.
Epidemiology and Ecology of Opportunistic Premise Plumbing Pathogens: <i>Legionella pneumophila</i> , <i>Mycobacterium avium</i> , and <i>Pseudomonas aeruginosa</i>
Authors: Joseph O. Falkinham, Elizabeth D. Hilborn, Matthew J. Arduino, Amy Pruden, Marc A. Edwards
Journal: Environmental Health Perspectives (2015)

Legionella pneumophila, Mycobacterium avium, and Pseudomonas aeruginosa are opportunistic premise plumbing pathogens (OPPPs) that persist and grow in household plumbing, habitats they share with humans. Infections caused by these OPPPs involve individuals with preexisting risk factors and frequently require hospitalization.The objectives of this report are to alert professionals of the impact of OPPPs, the fact that 30% of the population may be exposed to OPPPs, and the need to develop means to reduce OPPP exposure. We herein present a review of the epidemiology and ecology of these three bacterial OPPPs, specifically to identify common and unique features.A Water Research Foundation-sponsored workshop gathered experts from across the United States to review the characteristics of OPPPs, identify problems, and develop a list of research priorities to address critical knowledge gaps with respect to increasing OPPP-associated disease.OPPPs share the common characteristics of disinfectant resistance and growth in biofilms in water distribution systems or premise plumbing. Thus, they share a number of habitats with humans (e.g., showers) that can lead to exposure and infection. The frequency of OPPP-infected individuals is rising and will likely continue to rise as the number of at-risk individuals is increasing. Improved reporting of OPPP disease and increased understanding of the genetic, physiologic, and structural characteristics governing the persistence and growth of OPPPs in drinking water distribution systems and premise plumbing is needed.Because broadly effective community-level engineering interventions for the control of OPPPs have yet to be identified, and because the number of at-risk individuals will continue to rise, it is likely that OPPP-related infections will continue to increase. However, it is possible that individuals can take measures (e.g., raise hot water heater temperatures and filter water) to reduce home exposures.
83 HISTOLOGICAL DIVERSITY IN CHOLANGIOCELLULAR CARCINOMA SUGGESTING DIFFERENT CELLS OF ORIGIN: INTRAHEPATIC PROGENITOR CELLS VERSUS HILAR MUCIN PRODUCING CELLS
Authors: M. Komuta, O. Govaere, S. Vander Borght, R. De Vos, V. Vandecaveye, C. Verslype, W. Van Steenbergen, R. Aerts, J. Pirenne, B. Topal, F. Nevens, V.J. Desmet, T. Roskams
Journal: Journal of Hepatology (2011)
Ercp: Diagnostic and Therapeutic Applications. Edited by I. Jacobson, 271 pp. New York: Elsevier, 1989. $59.50
Authors: Jerome D. Waye
Journal: Hepatology (1990)

HepatologyVolume 11, Issue 5 p. 900-901 Book ReviewFree Access ERCP: Diagnostic and therapeutic applications. Edited by I. Jacobson, 271 pp. New York: Elsevier, 1989. $59.50 Jerome D. Waye M. D., Jerome D. Waye M. D. Mount Sinai Hospital and Lenox Hill Hospital New York, NY 10029Search for more papers by this author Jerome D. Waye M. D., Jerome D. Waye M. D. Mount Sinai Hospital and Lenox Hill Hospital New York, NY 10029Search for more papers by this author First published: May 1990 https://doi.org/10.1002/hep.1840110537AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume11, Issue5May 1990Pages 900-901 RelatedInformation
338 THE SYNERGISTIC EFFECT OF CO-ADMINISTRATION OF HMG-COA REDUCTASE INHIBITOR AND SELECTIVE COX-2 INHIBITOR AGAINST HEPATOCELLULAR CARCINOMA CELLS IS MEDIATED BY INHIBITION OF NF-KB/AKT PATHWAY
Authors: S.J. Lee, H.I. Yim, J.W. Hwang, H.J. Lee, E.L. Yoon, S.J. Suh, J.J. Hyun, S.W. Jung, J.S. Koo, R.S. Choung, J.H. Kim, Y.S. Seo, J.E. Yeon, S.H. Um, K.S. Byun, S.W. Lee, J.H. Choi
Journal: Journal of Hepatology (2012)
Cataracts in Asthmatics Treated with Corticosteroids
Authors: James E. Leibold
Journal: JAMA (1963)

Systemic corticosteroid therapy recently has been postulated as an etiologic factor in formation of posterior subcapsular cataracts,<sup>1-3</sup>with 39% to 42% incidence of posterior subcapsular cataracts reported in patients with rheumatic diseases being treated with steroids. However, other authors<sup>4-6</sup>have reported a much lower incidence. For many patients with asthma corticosteroid therapy is the only treatment available which will permit reasonably normal activities. But the physician must weigh the favorable results against possible disadvantages, including the possibility of formation of posterior subcapsular cataracts, and must consider the medicolegal aspects of such therapy. Therefore, a group of 220 inpatients at the National Jewish Hospital at Denver was examined to determine the incidence of posterior subcapsular cataracts. Seventy-two of these were patients with asthma from the Asthma-Allergy Service. <h3>Method of Study</h3> The 72 asthmatic patients studied were between 8 and 65 years old. The pupils of all patients were