Splenectomy in Felty's Syndrome
Authors: ROBERT A. GREEN
Journal: Annals of Internal Medicine (1966)

Article1 June 1966Splenectomy in Felty's SyndromeROBERT A. GREEN, M.D., VINCENT L. FROMKE, M.D.ROBERT A. GREEN, M.D.Search for more papers by this author, VINCENT L. FROMKE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-6-1265 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSplenomegaly occurs in uncomplicated rheumatoid arthritis in about 5 to 10% of patients, but the association of splenomegaly, arthritis, and leukopenia, known as Felty's syndrome, is quite rare, perhaps in the range of 1 in 300 cases of rheumatoid arthritis. Anemia and occasionally thrombocytopenia may also occur, and these cytopenias have most often been explained as being due to hypersplenism. Hypersplenism is an uncertain concept at best, and in a pathologic condition such as rheumatoid arthritis, the relationship of the enlarged spleen and abnormalities in the blood should be considered cautiously. This is particularly true when it comes to the...References1. FELTY AR: Chronic arthritis in the adult associated with splenomegaly and leukopenia; a report of five cases of an unusual syndrome. Bull. Hopkins Hosp. 35: 16, 1924. Google Scholar2. DENKOZUMPFT CWCW: Chronic arthritis with splenomegaly and leukopenia. Arthritis Rheum. 5: 478, 1962. CrossrefMedlineGoogle Scholar3. HAHNMAYNEKIELY RGJGJ: Clinical and hematologic study of Felty's syndrome (abstract). Arthritis Rheum. 6: 275, 1963. Google Scholar4. FRANKLINKUNKELWARD EOHGJR: Clinical studies of seven patients with rheumatoid arthritis and uniquely large amounts of rheumatoid factor. Arthritis Rheum. 1: 400, 1958. CrossrefMedlineGoogle Scholar5. CALABRESIEDWARDSSCHILLING PEARF: Fluorescent antiglobulin studies in leukopenic and related disorders. J. Clin. Invest. 38: 2091, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, MinnesotaFrom the Department of Medicine, St. Louis Park Medical Center, and the Department of Medicine, University of Minnesota, Minneapolis, Minn.Requests for reprints should be addressed to Robert A. Green, M.D., 4959 Excelsior Blvd., Minneapolis, Minn. 55416. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPathogenesis of neutropenia in large granular lymphocyte leukemia and Felty syndromeSurgical aspects of splenic disease and lymphomaTreatment of the neutropenia of Felty syndromeSplenectomy for splenomegaly and secondary hypersplenismFelty's syndrome: When is splenectomy indicated?Chronische Polyarthritis und Felty-SyndromDermatologic conditions reported in patients with rheumatoid arthritisFelty's Syndrome: Effects of Splenectomy Upon Granulocyte Count and Granulocyte-Associated IgGTHERESA M. BLUMFELDER, M.D., GERALD L. LOGUE, M.D., DAVID S. SHIMM, M.D.Neutrophil kinetics in Felty's syndromeFelty syndromeThe rarity of felty's syndrome in blacksFelty's syndrome without splenomegalyFelty's syndromeOPERATION-DAY BLOOD-TRANSFUSION AND RENAL TRANSPLANTATIONFELTY'S SYNDROMENEBULISED SALBUTAMOL IN ADULT ASTHMAThe neutropenia of felty's syndromeLeukopenia — A New Immune Mechanism?Felty's Syndrome: Granulocyte-Bound Immunoglobulin G and SplenectomyGERALD LOGUE, M.D.Macrophages and Their Disorders in ManRetardation of colony growth of in vitro bone marrow culture using sera from patients with felty' syndrome, disseminated lupus erythematosus (sle), rheumatoid arthritis, and other disease statesCirrhosis of the Liver in Felty' SyndromeChemotaxis of Polymorphonuclear Leukocytes from Patients with Systemic Lupus Erythematosus and Felty's SyndromeSplenomegaly in Rheumatoid ArthritisFelty's Syndrome: Long-Term Follow-up After SplenectomyRICK A. MOORE, M.D., CAROLYN M. BRUNNER, M.D., WILLIAM R. SANDUSKY, M.D., BYRD S. LEAVELL, M.D., F.A.C.P.Felty's syndrome. A clinical and pathological survey of 21 patients and their response to treatment.Hypersplenism due to disseminated candidiasis in a patient with acute leukemiaClinical and Serologic Observations on 27 Patients with Felty's SyndromeAnemia in Rheumatoid Arthritis 1 June 1966Volume 64, Issue 6Page: 1265-1270KeywordsAnemiaArthritisBloodFelty syndromeHemoglobinNeutropeniaRheumatoid arthritisSplenectomySplenomegaly Issue Published: 1 June 1966 PDF downloadLoading ...