Primary Biliary Cirrhosis Treated with Low-Dose Oral Pulse Methotrexate
Authors: Marshall M. Kaplan
Journal: Annals of Internal Medicine (1988)

Brief Reports1 September 1988Primary Biliary Cirrhosis Treated with Low-Dose Oral Pulse MethotrexateMarshall M. Kaplan, MD, Tamsin A. Knox, MD, Sanjeev Arora, MDMarshall M. Kaplan, MDSearch for more papers by this author, Tamsin A. Knox, MDSearch for more papers by this author, Sanjeev Arora, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-5-429 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThere is no totally effective treatment for primary biliary cirrhosis, a chronic, progressive liver disease that most often affects middle-aged women (1). Patients treated with colchicine show improved results on biochemical tests of liver function, and colchicine appears to slow the progression of this disease, but it does not improve symptoms or liver histology (2, 3). We recently reported (4) that low-dose oral pulse methotrexate produced clinical, biochemical, and histologic remission in two patients with primary sclerosing cholangitis. Because there are clinical and immunologic similarities between primary sclerosing cholangitis and primary biliary cirrhosis (5), we studied two women with symptomatic...References1. Kaplan M. Primary biliary cirrhosis. N Engl J Med. 1987;316:521-8. CrossrefMedlineGoogle Scholar2. KaplanAllingZimmerman MDH. A prospective trial of colchicine for primary biliary cirrhosis. N Engl J Med. 1986;315:1448-54. CrossrefMedlineGoogle Scholar3. WarnesSmithLee TAF. A controlled trial of colchicine in primary biliary cirrhosis [Abstract]. Hepatology. 1984;4:1022. Google Scholar4. KaplanAroraPincus MSS. Primary sclerosing cholangitis and low-dose oral pulse methotrexate: clinical and histologic response. Ann Intern Med. 1987;106:231-5. LinkGoogle Scholar5. WiesnerLaRussoLudwigDickson RNJE. Comparison of the clinicopathologic features of primary sclerosing cholangitis and primary biliary cirrhosis. Gastroenterology. 1985;88(1 Pt 1):108-14. CrossrefMedlineGoogle Scholar6. ChristensenNeubergerCrowe EJJ. Beneficial effect of azathioprine and prediction of prognosis in primary biliary cirrhosis: final results of an international trial. Gastroenterology. 1985;89:1084-91. CrossrefMedlineGoogle Scholar7. HoofnagleDavisSchafer JGD. Randomized trial of chlorambucil for primary biliary cirrhosis. Gastroenterology. 1986;91:1327-34. CrossrefMedlineGoogle Scholar8. WiesnerDicksonLindorJorgensonLaRussoBaldus REKRNW. A controlled clinical trial evaluating cyclosporin in the treatment of primary biliary cirrhosis: a preliminary report [Abstract]. Hepatology. 1987;7:1025. Google Scholar9. MinukBohmeBurgess GCE. A prospective, double-blind, randomized, controlled trial of cyclosporin A in primary biliary cirrhosis [Abstract]. Hepatology. 1987;7:1039. Google Scholar10. Zimmerman H. Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver. New York: Appleton-Century-Crofts; 1978:526. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From the New England Medical Center Hospitals and Tufts University School of Medicine, Boston, Massachusetts. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRisk of liver disease in methotrexate treated patientsCo-occurrence of Idiopathic Granulomatous Hepatitis and Primary Biliary CirrhosisAnalysis of the clinical relevance of antimitochondrial antibodies to the β- and γ-subunits of the F1F0-ATPase in patients with primary biliary cirrhosisMethotrexate in Patients with Primary Biliary Cirrhosis Who Respond Incompletely to Treatment With Ursodeoxycholic AcidMethotrexate for primary biliary cirrhosisPrimary Biliary CirrhosisMethotrexate (MTX) plus ursodeoxycholic acid (UDCA) in the treatment of primary biliary cirrhosisMethotrexate for primary biliary cirrhosisA randomized controlled trial of colchicine plus ursodiol versus methotrexate plus ursodiol in primary biliary cirrhosis: Ten-year resultsMethotrexate for primary biliary cirrhosisMethotrexate therapy for primary biliary cirrhosisTreatment of primary biliary cirrhosisA prospective trial of colchicine and methotrexate in the treatment of primary biliary cirrhosisMETHOTREXATE USE IN MISCELLANEOUS INFLAMMATORY DISEASESThe combination of ursodeoxycholic acid and methotrexate for primary biliary cirrhosis is not better than ursodeoxycholic acid aloneIntestinal secretion of drugs. 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Peppercorn, MDUse of Methotrexate for Refractory Inflammatory Bowel DiseaseInflammatory Bowel Disease Revisited: Newer DrugsCharacterization of serum and urinary bile acids in patients with primary biliary cirrhosis by gas-liquid chromatography-mass spectrometry: effect of ursodeoxycholic acid treatment.Methotrexate in Corticosteroid-Resistant UrticariaMartin J. Weiner, MDChronic Liver Diseases: Current Therapeutic OptionsMethotrexate Induces Clinical and Histologic Remission in Patients with Refractory Inflammatory Bowel DiseaseRichard A. Kozarek, MD, David J. Patterson, MD, Martin D. Gelfand, MD, V. Alin Botoman, MD, Terrence J. Ball, MD, Kenneth R. Wilske, MD 1 September 1988Volume 109, Issue 5Page: 429-431KeywordsColchicineHeart rateLiverLiver diseasesLiver function testsMethotrexateOral medicinePrimary biliary cirrhosisPrimary sclerosing cholangitisResearch grants Issue Published: 1 September 1988 PDF DownloadLoading ...