tbuckley/cabot-search huggingface dataset:
The use of selective immunosuppressive therapy on myelodysplastic syndromes in targeted populations results in good response rates and avoids treatment‐related disease progression
Authors: Li Xiao, Zhu Qi, Chen Qiusheng, Xu Li, Song Luxi, Wu Lingyun
Journal: American Journal of Hematology (2011)

Abstract To determine the treatment response and disease progression in strictly selected patients with myelodysplastic syndrome undergoing immunosuppressive therapy (IST), patients were required to have an international prostate symptom score (IPSS) score ≤ 1.0 and at least one of the following conditions: (1) expression of the HLA‐DR15 allele, (2) bone marrow (BM) cellularity of less than 30%, and (3) abnormal immune index of BM T‐lymphocytes.The exclusion criteria were as follows: (1) ≥ 5% marrow myeloblasts, (2) poor karyotype, and (3) diagnosis of concurrent nonhematological malignancy. Patients received antithymocyte globulin followed by cyclosporine A (CsA) or CsA alone for at least 3 months. Seventy‐one cases were analyzed. The total response rate was 77.5% (55/71 cases) with 11 complete responses. The response rate was positively correlated with the number of recruitment criteria met. Patients with an abnormal CD8, an abnormal CD4, or both had similar response rates. Patients who responded to treatment had significantly lower Th1 and Tc1 levels after treatment ( P &lt; 0.01 and P &lt; 0.001, respectively), and six of eight patients with abnormal chromosomes did not show obviously abnormal clonal expansion when reassessed after IST. During the median observation period of 24 months, only two cases exhibited disease progression. At the median observation of 24 months, 35 of 55 responders (63.6%) maintained a hematological response, and 60 of 71 patients (84.5%) were still alive. The strictly selective use of IST may yield high response rates and can avoid treatment‐related acute myeloid leukemia transformation. IST significantly reduces Th1 and Tc1 levels without causing malignant clonal expansion. Am. J. Hematol., 2012. © 2011 Wiley Periodicals, Inc.
NEW HYPOTHALAMIC HORMONE, CORTICOTROPIN-RELEASING FACTOR, SPECIFICALLY STIMULATES THE RELEASE OF ADRENOCORTICOTROPIC HORMONE AND CORTISOL IN MAN
Authors: A Grossman, L Perry, A.V Schally, LesleyH Rees, A.C Nieuwenhuyzen Kruseman, Susan Tomlin, D.H Coy, Ana-Maria Comaru-Schally, G.M Besser
Journal: The Lancet (1982)
Enlarging Head Size and Metastatic Neuroblastoma
Authors: James H. Gerson
Journal: JAMA (1975)

<h3>To the Editor.—</h3> Enlargement of the head and widening of the cranial sutures are recognized complications of metastatic neuroblastoma (227:659, 1974). We recently had a patient with a rapidly increasing head size that was found to be due to metastatic neuroblastoma. <h3>Report of a Case.—</h3> A 2-year-old boy had increasing head size over a six-month period. He had suffered a traumatic hematoma of his forehead seven months earlier and had surgery for a right lateral rectus palsy one month ago. He also had mild lethargy and occasional projectile emesis for one to two weeks before referral. The patient had macrocephaly, with marked prominence of the frontal area, dilated superficial scalp veins, and mild proptosis bilaterally. His head circumference was 54 cm—more than 2 standard deviations above the mean for his age. Funduscopic examination disclosed bilateral venous engorgement. No masses or abnormal lymph nodes were palpable. Findings of a neurologic examination
Chronic Lyme Arthritis
Authors: ALLEN C. STEERE
Journal: Annals of Internal Medicine (1979)

Ten patients with Lyme arthritis have developed chronic involvement of one or both knees. Lyme arthritis was diagnosed by onset with erythema chronicum migrans (six patients); residence in Lyme, Connecticut (eight); seasonal onset in summer and early fall (nine); early periods of short recurrent attacks (nine); absence of rheumatoid factor (nine); and absence of symmetrical polyarthritis, morning stiffness, subcutaneous nodules, or antinuclear antibodies (in all). Five patients had synovectomies; pannus formation and underlying cartilage erosion were present in all. Seven of the 10 patients had the same B-cell alloantigen, DRw2 (frequency in normal control subjects, 22%[ P< 0.005]), but did not have an increased frequency of the alloantigens associated with rheumatoid arthritis. Chronic Lyme arthritis, the result of an apparent tick-transmitted infection, resembles rheumatoid arthritis pathologically but generally differs from it in both prearticular and immunogenetic characteristics.
Pinch skin grafting or porcine dermis in venous ulcers.
Authors: E L Gilliland
Journal: BMJ (1987)

A;g~~4 5Map showing distribution of significant leukaemia incidence ratios (incidence ratio > 1 -0; p<005) at ages 0-14 in 143 electoral wards in West Berkshire and Basingstoke and North Hampshire District Health Authorities.Figures are numbers of cases.
Are we prepared to sacrifice good feeling for pensions?
Authors: Kinesh Patel
Journal: BMJ (2012)

Having two identities is always difficult—and it’s usually a bad idea. Just ask the Liberal Democrats how difficult it is to be faithful to their two different masters—their ideology and the Tories. At least for them it will all be over in three years. ⇑

Some of their discomfort must result from the government’s attack on public sector pensions. The press has widely described the cost of senior doctors’ pensions as unaffordable, and this has led to doctors’ exposure to a new dose of vitriol …
TWO CASES OF OBJECTIVE AURAL TINNITUS DUE TO THE ACTION OF TUBOPALATAL MUSCLES.
Authors: WALTER A. WELLS
Journal: JAMA (1905)

Subjective noises in the ear, loud, distressing, and of various description, buzzing, ringing, roaring, singing, steaming, whistling, is one of the most familiar symptoms encountered in the practice of otology. These sounds are sometimes so loud and intense that the afflicted patient is led to think that bystanders can hear them as well as himself, and it not infrequently happens that the physician is asked if he also can not hear the noise which the patient hears so distinctly. But cognizant of their purely subjective character, the physician usually only laughs at the query. It is worth while, however, to bear in mind that exceptionally this inquiry on the part of the patient is entirely justified and that if we put our ear close to his, we will discover that the sound, which we thought was heard only subjectively by the patient, may actually be heard objectively by another
Multinational development and validation of an early prediction model for delirium in ICU patients
Authors: A. Wassenaar, M. van den Boogaard, T. van Achterberg, A. J. C. Slooter, M. A. Kuiper, M. E. Hoogendoorn, K. S. Simons, E. Maseda, N. Pinto, C. Jones, A. Luetz, A. Schandl, W. Verbrugghe, L. M. Aitken, F. M. P. van Haren, A. R. T. Donders, L. Schoonhoven, P. Pickkers
Journal: Intensive Care Medicine (2015)

Delirium incidence in intensive care unit (ICU) patients is high and associated with poor outcome. Identification of high-risk patients may facilitate its prevention.To develop and validate a model based on data available at ICU admission to predict delirium development during a patient's complete ICU stay and to determine the predictive value of this model in relation to the time of delirium development.Prospective cohort study in 13 ICUs from seven countries. Multiple logistic regression analysis was used to develop the early prediction (E-PRE-DELIRIC) model on data of the first two-thirds and validated on data of the last one-third of the patients from every participating ICU.In total, 2914 patients were included. Delirium incidence was 23.6%. The E-PRE-DELIRIC model consists of nine predictors assessed at ICU admission: age, history of cognitive impairment, history of alcohol abuse, blood urea nitrogen, admission category, urgent admission, mean arterial blood pressure, use of corticosteroids, and respiratory failure. The area under the receiver operating characteristic curve (AUROC) was 0.76 [95% confidence interval (CI) 0.73-0.77] in the development dataset and 0.75 (95% CI 0.71-0.79) in the validation dataset. The model was well calibrated. AUROC increased from 0.70 (95% CI 0.67-0.74), for delirium that developed <2 days, to 0.81 (95% CI 0.78-0.84), for delirium that developed >6 days.Patients' delirium risk for the complete ICU length of stay can be predicted at admission using the E-PRE-DELIRIC model, allowing early preventive interventions aimed to reduce incidence and severity of ICU delirium.
THE PROGNOSTIC ROLE OF DOBUTAMINE STRESS CONTRAST ECHO IN PATIENTS WITH KNOWN OR SUSPECTED CORONARY ARTERY DISEASE IN DIFFERENT AGE GROUPS
Authors: Constantina Aggeli, Ioannis Felekos, Polychronis Stergiou, Georges Roussakis, Erifili Venieri, Stauroula Lagoudakou, Christodoulos Stefanadis
Journal: Journal of the American College of Cardiology (2012)
The Significance of Aschoff Bodies in the Left Atrial Appendage
Authors: Wilbur A. Thomas, James H. Averill, Benjamin Castleman, Edward F. Bland
Journal: New England Journal of Medicine (1953)

THE development of a practical operation for mitral stenosis during the past five years has provided an unusual opportunity for interval study of the myocardium in a large number of patients with chronic rheumatic heart disease. The high incidence of Aschoff bodies in the surgical specimens has been an unexpected finding (Table 1). In our series of 40 cases it was 55 per cent.This is out of line with the clinical evidence of rheumatic activity and is especially puzzling since less than half the group had a history of rheumatic fever, and all had been carefully scrutinized to exclude . . .
RELATIONSHIP BETWEEN LEFT ATRIAL VOLTAGE AND THE LEFT ATRIAL FLOW PATTERN BY TRANSESOPHAGEAL CONTRAST ECHOCARDIOGRAPHY IN PATIENTS WITH ATRIAL FIBRILLATION
Authors: Jung Myung Lee, In-Jeong Cho, Sanghoon Shin, Chi Young Shim, Hyuk-Jae Chang, Geu-Ru Hong, Hui-Nam Pak, Jong-Won Ha, Namsik Chung
Journal: Journal of the American College of Cardiology (2014)
An Approximate Derivation for Stereoscopic Vectorcardiograms with the Equilateral Tetrahedron
Authors: J. A. CRONVICH, J. A. ABILDSKOV, C. E. JACKSON, G. E. BURCH
Journal: Circulation (1950)

A simple electrode arrangement, which permits the derivation of stereoscopic projections of the spatial vectorcardiogram, eliminates the need for constructing models. The visual impression obtained from this method agrees satisfactorily with that from carefully constructed models.
Seminars in Clinical Neuropsychiatry
Authors: Stephen K. Brannan
Journal: JAMA (1997)

This journal offers reviews of key neuropsychiatric topics for clinicians, with the aim of tying research findings to the needs of clinical practice. It strives to "unite theory, findings, and therapies in cohesive, comprehensive presentations." The first three issues we examined did contain important, timely, and interesting topics that included advances in neuroimaging, neuropsychiatric syndromes in the developmentally disabled, and brain damage and legal responsibility. Each issue includes a brief introduction from the editor, followed by a few pages from a guest editor who has been invited to solicit submissions from others on the featured topic. Each issue has six to nine reviews organized around the central theme. The guest editor comments on how each of the articles in the issue conforms to or amplifies the theme. Authors attempt to present information in a readable format that may serve as a springboard for further investigation. Most articles summarize the
Burning Sensation and Potency of Nitroglycerin Sublingually
Authors: Herbert W. Copelan
Journal: JAMA (1972)

The unwitting use of deteriorated nitroglycerin confuses the diagnosis and treatment of angina pectoris. Knowledge of the potency of each tablet at the time of its use would eliminate the confusion. The clinical impression that fresh nitroglycerin causes a burning sensation that provides a practical index of potency was tested. Thirty inexperienced subjects were tested in a double-blind study with fresh and artificially aged nitroglycerin. Twenty-seven reported immediate sublingual burning with fresh drug and decreased or absent burning with aged tablets (<i>P</i>&lt;0.001). Surprisingly, the faint sweetness of nitroglycerin, a true taste sensation, had no value as an index of freshness. Fresh drug caused more systemic effect (<i>P</i>&lt; 0.001), and this correlated with burning sensation (<i>P</i>&lt; 0.02 and<i>P</i>&lt; 0.001). Localized sublingual erythema and vasodilatation occurred simultaneously with burning, suggesting that the burning sensation indicates potency by reflecting topical activity.
Human Leukocyte Antigen I Knockdown Human Embryonic Stem Cells Induce Host Ignorance and Achieve Prolonged Xenogeneic Survival
Authors: Tobias Deuse, Martina Seifert, Neil Phillips, Andrew Fire, Dolly Tyan, Mark Kay, Philip S. Tsao, Xiaoqin Hua, Joachim Velden, Thomas Eiermann, Hans-Dieter Volk, Hermann Reichenspurner, Robert C. Robbins, Sonja Schrepfer
Journal: Circulation (2011)

Although human embryonic stem cells (hESC) have enormous potential for cell replacement therapy of heart failure, immune rejection of hESC derivatives inevitably would occur after transplantation. We therefore aimed to generate a hypoantigeneic hESC line with improved survival characteristics.Using various in vivo, nonischemic, hindlimb xenotransplant models (immunocompetent and defined immunodefective mouse strains) as well as human in vitro T-cell and natural killer (NK)-cell assays, we revealed a central role for T cells in mediating hESC rejection. The NK-cell susceptibility of hESC in vivo was found to be low, and the NK response to hESC challenge in vitro was negligible. To reduce the antigenicity of hESC, we successfully generated human leukocyte antigen (HLA) I knockdown cells (hESC(siRNA+IB)) using both HLA I RNA interference (siRNA) and intrabody (IB) technology. HLA I expression was ≈99% reduced after 7 days and remained low for weeks. Cellular immune recognition of these hESC(siRNA+IB) was strongly reduced in both xenogeneic and allogeneic settings. Immune rejection was profoundly mitigated after hESC(siRNA+IB) transplantation into immunocompetent mice, and even long-term graft survival was achieved in one third of the animals without any immunosuppression. The survival benefit of hESC(siRNA+IB) was further confirmed under ischemic conditions in a left anterior descending coronary artery ligation model.HLA I knockdown hESC(siRNA+IB) provoke T-cell ignorance and experience largely mitigated xenogeneic rejection. By generating hypoantigeneic hESC lines, the generation of acceptable hESC derivatives may become a practical concept and push cell replacement strategies forward.
Epidermal Growth Factor and Insulin Use in Corneal Preservation
Authors: Jonathan H. Lass, David C. Musch, Judy F. Gordon, Ronald A. Laing, William E. Bruner, Jonathan H. Lass, William J. Reinhart, Francis W. Price, William E. Whitson, Jay H. Krachmer, Marian S. Macsai, Gary A. Varley, Richard A. Eiferman, Roger F. Meyer, H. Kaz Soong, Alan Sugar, Richard H. Keates, Richard G. Lembach, John W. Cowden, Jonathan H. Lass, David C. Musch
Journal: Ophthalmology (1994)
Macrophages are essential contributors to kidney injury in murine cryoglobulinemic membranoproliferative glomerulonephritis
Authors: Shunhua Guo, Tomasz A Wietecha, Kelly L Hudkins, Yujiro Kida, Min W Spencer, Warangkana Pichaiwong, Ichiro Kojima, Jeremy S Duffield, Charles E Alpers
Journal: Kidney International (2011)
Humanized anti–IFN-γ (HuZAF) in the treatment of psoriasis
Authors: Jamie L. Harden, Leanne M. Johnson-Huang, Maria Francesca Chamian, Edmund Lee, Tillman Pearce, Craig L. Leonardi, Asifa Haider, Michelle A. Lowes, James G. Krueger
Journal: Journal of Allergy and Clinical Immunology (2014)
The STAT Pathway Mediates Late-Phase Immunity against Plasmodium in the Mosquito Anopheles gambiae
Authors: Lalita Gupta, Alvaro Molina-Cruz, Sanjeev Kumar, Janneth Rodrigues, Rajnikant Dixit, Rodolfo E. Zamora, Carolina Barillas-Mury
Journal: Cell Host & Microbe (2009)
Parathormone Levels vs. Parathormone Function
Authors: Christine Waterhouse, Robert E. Heinig
Journal: New England Journal of Medicine (1976)

Calcium loss from the body or circulating fluids is usually not reflected in sustained lowering of the serum calcium, largely because of the very efficient homeostatic control of serum calcium via bone stores. Thus, fecal calcium loss as "soaps" in steatorrhea and intra-abdominal calcium saponification in pancreatitis have largely fallen into disrepute as causative factors for the maintenance of hypocalcemia seen in these conditions. This development has led to a series of recent investigations1 2 3 of possible hormonal abnormalities in acute pancreatitis, the article by Robertson et al. in this issue of the Journal being the most recent.Most observers agree . . .
Discoidin Domain Receptor 1 Receptor Tyrosine Kinase Induces Cyclooxygenase-2 and Promotes Chemoresistance through Nuclear Factor-κB Pathway Activation
Authors: Sanjeev Das, Pat P. Ongusaha, Yoon Sun Yang, Jin-Mo Park, Stuart A. Aaronson, Sam W. Lee
Journal: Cancer Research (2006)

Abstract Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase activated by various types of collagens and is known to play a role in cell attachment, migration, survival, and proliferation. However, little is known about the molecular mechanism(s) underlying the role of DDR1 in cancer. We report here that DDR1 induces cyclooxygenase-2 (Cox-2) expression resulting in enhanced chemoresistance. Depletion of DDR1-mediated Cox-2 induction using short hairpin RNA (shRNA) results in increased chemosensitivity. We also show that DDR1 activates the nuclear factor-κB (NF-κB) pathway and blocking this activation by an IκB superrepressor mutant results in the ablation of DDR1-induced Cox-2, leading to enhanced chemosensitivity, indicating that DDR1-mediated Cox-2 induction is NF-κB dependent. We identify the upstream activating kinases of the NF-κB pathway, IKKβ and IKKγ, as essential for DDR1-mediated NF-κB activation, whereas IKKα seems to be dispensable. Finally, shRNA-mediated inhibition of DDR1 expression significantly enhanced chemosensitivity to genotoxic drugs in breast cancer cells. Thus, DDR1 signaling provides a novel target for therapeutic intervention with the prosurvival/antiapoptotic machinery of tumor cells. (Cancer Res 2006; 66(16): 8123-30)
Influence of Procedural Success on Immediate and Long-Term Clinical Outcome of Patients Undergoing Percutaneous Revascularization of Occluded Coronary Artery Bypass Vein Grafts
Authors: Peter B. Berger, Malcolm R. Bell, Diane E. Grill, Robert Simari, Guy Reeder, David R. Holmes
Journal: Journal of the American College of Cardiology (1996)
AB0095 Forelimb Development in the Mouse: an Original Model of Organo-Dependent Lymphangiogenesis
Authors: C. Nguyen, R. Skoczylas, C. Pichol-Thiévend, E. Frampton, F. Rannou, M. François
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Quantitative and qualitative changes affecting the lymphatic network are associated with limb and joint diseases including rheumatoid arthritis and osteoarthritis at the adult age. However how lymphatics develop during embryogenesis in the limbs remain largely unexplored. <h3>Objectives</h3> To describe for the first time lymphangiogenesis in mouse forelimbs and joints during early embryogenesis. <h3>Methods</h3> Prox1 is a key transcription factor involved in lymphatic specification and remodelling. Taking advantage of the Prox1-GFP reporter transgenic mouse line, we described lymphangiogenesis in the forelimbs and in the joints during early embryogenesis from 9.5 (E9.5) to 14.5 (E14.5) days <i>post-coitum</i> using confocal imaging on fixed samples stained with specific markers for lymphatic and vascular endothelia, as well as for surrounding specifying tissues including cartilage, muscles and peripheral nerves. Timelapse imaging was also performed on specimens collected at E11.5 and E12.5 to address lymphangiogenesis <i>ex vivo</i>. <h3>Results</h3> From E9.5 to E10.5, Prox1 positive cells emerge directly from the cardinal vein and are located at the limb bud, following an antero-posterior gradient. Elongated shape suggests migrating cells. Other markers for lymphatics including neuropillin-2 and endothelium including endomucin are expressed in a dense unpatterned vascular network involving the future forelimb suggesting an undifferentiated primary capillary plexus. From E11.5 to E12.5, this unpatterned network undergoes an extensive remodelling with the formation of an avascular zone as the skeleton mesenchyme is condensing. More strikingly, Prox1 positive cells emerge directly from this capillary plexus, suggesting an original mechanism of local lymphangiogenesis. In addition to this process, <i>ex vivo</i> imaging at E11.5 and E12.5 reveals that sprouting, branching, cell division and networking from the forelimb marginal vein also occur, still following an antero-posterior gradient. Later on, vascular network patterning is coordinated to other tissues specification including peripheral nerves, joints and muscles. <h3>Conclusions</h3> Altogether, our data suggest that the development of lymphatics in the forelimb represents an original model of organo-dependent lymphangiogenesis associating migration from the cardinal vein and local lymphangiogenesis from local precursors. <h3>Acknowledgements</h3> Dr Christelle Nguyen received fundings from the French Society of Rheumatology (SFR), the French Society of Rehabilitation Medicine (SOFMER) and the Bettencourt-Schueller Foundation. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3954
Cardiac Disease and Its Treatment—Some Physiological Correlations
Authors: Glenn A. Langer, Allan J. Brady, Kenneth I. Shine, Joy A. Sopis
Journal: Annals of Internal Medicine (1970)

Certain aspects of cardiac function as related to the normal and diseased heart are summarized. Topics discussed include: [1] myocardial ultrastructuralfunctional relationships; [2] the process of electrical excitation and conduction and the basic physiology of arrhythmias and conduction defects; [3] methods of evaluation of myocardial failure in the patient and present concepts of the cellular basis of heart failure; and [4] the role of the ions in the control of the myocardial contractile process and the possible relationships between ionic flux and digitalis action.
Relative potency of testosterone and dihydrotestosterone in preventing atrophy and apoptosis in the prostate of the castrated rat.
Authors: A S Wright, L N Thomas, R C Douglas, C B Lazier, R S Rittmaster
Journal: Journal of Clinical Investigation (1996)

Although dihydrotestosterone (DHT) is the principal androgen in the prostate, testosterone can also act as an androgen in this tissue. To determine the relative potencies of testosterone and DHT in preventing prostate regression, castrated rats were implanted for 4 d with varying doses of testosterone in the presence or absence of the 5alpha-reductase inhibitor finasteride. In the absence of finasteride, testosterone in the prostate is converted to DHT, creating an intraprostatic DHT dose response. In the presence of finasteride, this conversion is blocked, and an intraprostatic testosterone dose response is achieved. DHT was 2.4 times more potent than testosterone at maintaining normal prostate weight and duct lumen mass, a measure of epithelial cell function. The two androgens were equipotent at preventing DNA fragementation and expression of testosterone-repressed prostate message, two measures of apoptosis (cell death). The intraprostatic testosterone concentration that results from finasteride treatment in rats is sufficient to inhibit apoptosis but will not maintain normal epithelial cell activity. In conclusion, whereas DHT is more potent than testosterone at stimulating prostate epithelial cell function as measured by ductal mass, the two androgens are equipotent at preventing prostate cell death after castration. These results explain why finasteride causes prostate involution in the rat with minimal evidence of prostate cell death.