tbuckley/cabot-search huggingface dataset:
Breast Cancer in Older Women: Quality of Life and Psychosocial Adjustment in the 15 Months After Diagnosis
Authors: Patricia A. Ganz, Edward Guadagnoli, Mary Beth Landrum, Timothy L. Lash, William Rakowski, Rebecca A. Silliman
Journal: Journal of Clinical Oncology (2003)

Purpose: We examined the health-related quality of life (QOL) of a cohort of older women with breast cancer after their diagnosis. Patients and Methods: Six hundred ninety-one women aged 65 years and older were interviewed approximately 3 months after breast cancer surgery and two additional times in the following year using standardized QOL measures. Demographic factors, breast cancer treatments, and comorbid conditions were used to model ratings of health-related QOL over time. Self-perceived health and psychosocial adjustment at 15 months after surgery were modeled. Results: Physical and mental health scores declined significantly in the follow-up year, independent of age. However, a cancer-specific psychosocial instrument showed significant improvement in scores. Better 3-month physical and mental health scores, as well as better emotional social support, predicted more favorable self-perceived health 15 months after surgery. Psychosocial adjustment at 15 months was significantly predicted by better mental health, emotional social support, and better self-rated interaction with health care providers assessed at 3 months. Conclusion: Contrary to reports from younger women with breast cancer, we observed significant declines in the physical and mental health of older women in the 15 months after breast cancer surgery, whereas scores on a cancer-specific psychosocial QOL measure improved over time, consistent with patterns in younger women. Predictive models indicate that older women with impaired physical functioning, mental health, and emotional social support after surgery have poorer self-perceived health and psychosocial adjustment 1 year later. Interventions to address the physical and emotional needs of older women with breast cancer should be developed and evaluated to determine their impact on subsequent health-related QOL.
Review: Contrast-enhanced MRA is highly accurate for diagnosing steno-occlusions in peripheral arterial disease
Authors: Fausto Biancari, Tatu Juvonen
Journal: Annals of Internal Medicine (2011)

Source Citation Menke J, Larsen J. Meta-analysis: accuracy of contrast-enhanced magnetic resonance angiography for assessing steno-occlusions in peripheral arterial disease. Ann Intern Med. 2010;153:325-34. 20820041
Laser Removal of Radiation Tattoos
Authors: Murad Alam, Kenneth A. Arndt
Journal: Annals of Internal Medicine (2002)

Letters2 April 2002Laser Removal of Radiation TattoosMurad Alam, MD and Kenneth A. Arndt, MDMurad Alam, MDDermSurgery Associates; Houston, TX 77030 (Alam)Harvard Medical School; Boston, MA 02115 (Arndt)Search for more papers by this author and Kenneth A. Arndt, MDDermSurgery Associates; Houston, TX 77030 (Alam)Harvard Medical School; Boston, MA 02115 (Arndt)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-7-200204020-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We have noticed, with some bafflement, a reluctance among oncologists to refer patients for removal of positional tattoos placed to facilitate radiation therapy. Perhaps oncologists view this as a trivial concern compared with the cancer treatment itself, or perhaps they believe that the tattoos do not bother patients.In our experience, positional tattoos, especially those in cosmetically sensitive locations such as the presternal area and the breast, may contribute substantially to the dehumanization of patients grappling with a malignancy. When there is a hiatus in treatment or a prolonged remission, removal of the tattoos can be a ...References1. Varma S, Lanigan SW. Reasons for requesting laser removal of unwanted tattoos. Br J Dermatol. 1999;140:483-5. [PMID: 10233271] CrossrefMedlineGoogle Scholar2. Armstrong ML, Stuppy DJ, Gabriel DC, Anderson RR. Motivation for tattoo removal. Arch Dermatol. 1996;132:412-6. [PMID: 8629844] CrossrefMedlineGoogle Scholar3. Adrian RM, Griffin L. Laser tattoo removal. Clin Plast Surg. 2000;27:181-92. [PMID: 10812518] CrossrefMedlineGoogle Scholar4. Moreno-Arias GA, Casals-Andreu M, Camps-Fresneda A. Use of Q-switched alexandrite laser (755 nm, 100 nsec) for removal of traumatic tattoo of different origins. Lasers Surg Med. 1999;25:445-50. [PMID: 10602138] CrossrefMedlineGoogle Scholar5. Leuenberger ML, Mulas MW, Hata TR, Goldman MP, Fitzpatrick RE, Grevelink JM. Comparison of the Q-switched alexandrite, Nd:YAG, and ruby lasers in treating blue-black tattoos. Dermatol Surg. 1999;25:10-4. [PMID: 9935085] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: DermSurgery Associates; Houston, TX 77030 (Alam)Harvard Medical School; Boston, MA 02115 (Arndt) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByUltraviolet-Fluorescent Tattoo Facilitates Accurate Identification of Biopsy Sites 2 April 2002Volume 136, Issue 7Page: 558KeywordsAnesthesiaCancer treatmentEmotionsOutpatientsRadiation therapySurgeonsSurgery ePublished: 2 April 2002 Issue Published: 2 April 2002 CopyrightCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Second Neoplasm — A Complication of Cancer Chemotherapy
Authors: Bruce A. Chabner
Journal: New England Journal of Medicine (1977)

Chemotherapy has become increasingly important in the treatment of neoplastic disease in the past two decades. Appreciable numbers of patients with advanced Hodgkin's disease, choriocarcinoma, acute lymphocytic leukemia, testicular carcinoma and histiocytic lymphoma have achieved long-term disease-free survival largely as the result of aggressive chemotherapy. In addition, the use of antineoplastic drugs has recently been extended to the "adjuvant" situation and appears to delay, if not to prevent, recurrence in high-risk patients after primary surgical treatment of breast cancer.1 , 2 This progress has been realized despite substantial drug-related morbidity, and occasional mortality. The acute toxicity of antineoplastic chemotherapy affects a broad . . .
A 12-week treatment for dermatophyte toe onychomycosis terbinafine 250mg/day vs. itraconazole 200mg/day-a double-blind comparative trial
Authors: M. DE BACKER, P. DE KEYSER, C. DE VROEY, E. LESAFFRE
Journal: British Journal of Dermatology (1996)

Journal Article A 12–week treatment for dermatophyte toe onychomycosis terbinafine 250mg/day vs. itraconazole 200mg/day—a double‐blind comparative trial Get access M. DE BACKER, M. DE BACKER Sandoz Medical Department, Brussels, Beligium Dr M. De Backer, Sandoz Medical Dept, Chausée de Haecht 226, Haachtsesteenweg, 1030 Brussels, Belgium. Search for other works by this author on: Oxford Academic Google Scholar P. DE KEYSER, P. DE KEYSER Sandoz Medical Department, Brussels, Beligium Search for other works by this author on: Oxford Academic Google Scholar C. DE VROEY, C. DE VROEY Mycology, Institute of Tropical Medicine, Antwerp, Belgium Search for other works by this author on: Oxford Academic Google Scholar E. LESAFFRE E. LESAFFRE Biostatistical Centre KU, Leuven, Belgium Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 134, Issue s46, 1 June 1996, Pages 16–17, https://doi.org/10.1111/j.1365-2133.1996.tb15653.x Published: 01 June 1996
Global synthetic-lethality analysis and yeast functional profiling
Authors: Siew Loon Ooi, Xuewen Pan, Brian D. Peyser, Ping Ye, Pamela B. Meluh, Daniel S. Yuan, Rafael A. Irizarry, Joel S. Bader, Forrest A. Spencer, Jef D. Boeke
Journal: Trends in Genetics (2005)
Results of a Multicenter, Randomized, Double-Blind, Phase III Study of TAS-102 vs. Placebo, with Best Supportive Care (BSC), in Patients (PTS) with Metastatic Colorectal Cancer (MCRC) Refractory to Standard Therapies (RECOURSE)
Authors: T. Yoshino, R. Mayer, A. Falcone, A. Ohtsu, R. Garcia-Carbonero, N. Mizunuma, K. Yamazaki, Y. Shimada, J. Tabernero, Y. Komatsu, A. Sobrero, E. Boucher, M. Peeters, B. Tran, H.J. Lenz, A. Zaniboni, H. Hochster, F. Benedetti, M. Aivado, L. Makris, M. Ito, E. Van Cutsem
Journal: Annals of Oncology (2014)
THE INFLUENCE OF RADIATION ON LONGEVITY IN CANCER OF THE BREAST
Authors: ORVILLE N. MELAND
Journal: JAMA (1942)

In this paper I am presenting my experiences relative to the effect of radiation used alone or with surgery in cancer of the breast over a twelve year period from and including the years 1924 and 1935. There were 857 cases in all categories; of these, 803 have been traced—a follow-up of 94 per cent. Those patients who were not located are classed as lost but are not deducted; nor have deductions been made for those dying of intercurrent disease, as there is no way of ascertaining whether they might not have died of cancer had they lived. Since the Los Angeles Tumor Institute was originally a radiologic clinic, a preponderance of the patients in the early years were treated radiologically. Open incisional biopsy was frowned on and aspiration biopsy had not been perfected, so that diagnosis was based on clinical observations. When a fixed tumor is present or where
Pernicious Papillomavirus Infection
Authors: Robert D. Burk
Journal: New England Journal of Medicine (1999)

More than 100 years have passed since an association between sexual behavior and cancer of the cervix was reported. In the ensuing years, the elusive sexually transmitted agent has been intensively sought. It was not long ago that the herpes simplex virus (HSV) was thought to be this agent on the basis of serologic studies, and indeed, HSV remains in the collective consciousness of many physicians as a causative agent of cancer of the cervix, despite the lack of evidence supporting this conclusion. With the advent of recombinant DNA technology and the cloning of oncogenic human papillomaviruses (HPV), it became . . .
CHRONIC HEADACHE ASSOCIATED WITH PELVIC DISEASE.
Authors: F. H. DAVENPORT
Journal: JAMA (1906)

By chronic headache, as I understand it in this discussion, is meant not a constant headache, but one which recurs at more or less frequent intervals and is of a uniform type. This symptom is not very common in connection with pelvic disease. In taking 1,000 cases from my note book, I find it mentioned 98 times, constituting only about 10 per cent. In studying these cases and noting the pelvic condition with which the headache is associated, I find the greater part may be placed under two heads. First, those connected, as regards to time, with the menstrual function; second, those which seem to be due not especially to the particular pelvic disorder found in the case, but that seem to be an expression of the neurasthenia of which the pelvic lesion is one of the predisposing factors. <h3>1. Due to Menstrual Disturbance.</h3> —Taking the first group, I find
THE RATIO OF LEFT VENTRICULAR END SYSTOLIC VOLUME INDEX AND QRS DURATION IS A POTENT PREDICTOR OF RESPONSE IN PATIENTS WITH A LBBB UNDERGOING CARDIAC RESYNCHRONIZATION THERAPY
Authors: Jack Rickard, Alan Cheng, David Spragg, Bryan Baranowski, Stacey Yu, Bruce Wilkoff, Niraj Varma
Journal: Journal of the American College of Cardiology (2014)
Internet crawler uses unconventional information sources to track infectious disease outbreaks
Authors: S. Mayor
Journal: BMJ (2008)

An automated data gathering system that crawls the internet to gather information from non-traditional sources such as online news outlets, discussion forums, and government websites is proving effective in tracking emerging infectious diseases, says a new study ( PLoS Med 2008:5:e151 doi: 10.1371/journal.pmed.0050151).

Researchers from the Children’s Hospital Boston and Harvard Medical School developed HealthMap as a freely accessible and automated system that monitors and organises information on emerging diseases in real time. 

“Web-based sources can play an important role in early event detection . . . by providing current, highly local information about outbreaks, even from areas relatively invisible to traditional global public health efforts,” they wrote.

The existing network of traditional surveillance systems managed by health organisations and multinational agencies has wide gaps in geographical coverage and often suffers from …
A 61-Year-Old Man With Parkinson's Disease, 1 Year Later
Authors: Warren E. Enker
Journal: JAMA (1997)

<h3>To the Editor.</h3> —A recent Clinical Crossroads article<sup>1</sup>reviewed the course of a retired dentist 1 year after the presentation of his case at Neurology Grand Rounds. At this time, the patient paints a rather devastating picture of how his life has deteriorated in so many ways. To anyone who has ever witnessed the deterioration of a previously vital and vibrant patient who is disabled by Parkinson disease, however subjective the changes may seem, every one of this patient's physical and emotional changes is real. With the exception of some superficial comments about the patient's speech and about his inability to remain as active as he once was, Dr C, the primary care physician, has captured nothing about what the patient relates as his overall decline in well-being. When it comes to the patient's decline in cognitive function, the primary care physician indicates that despite the patient's complaints, an objective
Consensus or Coercion
Authors: William E. May
Journal: JAMA (1985)

There is an emerging issue that I have not heard much discussed, but that seems to me to pose a significant question. That is, will medicine be practiced in the future on the basis of the individual decisions of each physician and his patient, or will we see the development of a system of medical practice by consensus? Intrinsic to this question is the corollary: Which would be preferable?  Medicine is practiced today by a host of individual physicians, each free within the broad constraints of reason to choose the most appropriate path to the diagnosis and treatment of each patient. At every decision point, a choice is made from a range of alternatives. In most cases, there is at least the theoretical possibility that one choice would represent the best among that particular set of alternatives. But, as the selection is influenced by the knowledge and experience of the
Precise determination of toll-like receptor (TLR) 7 expression in multiple human tumor types
Authors: Marie Cumberbatch, Nicola Haughton, Emily Foster, Xiu Huan Yap, Simon Barry, Setsuko Yamamoto, Masashi Murata, Robert W Wilkinson, Christopher Womack
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts TLR7 agonists are being progressed as potential immunotherapeutics for the treatment of cancer. TLR7 agonism is believed to trigger a plasmacytoid dendritic cell driven immune response which drives anti-tumor efficacy. In addition to modulation of the immune system, TLR7 may be
Buccal Nitroglycerin Ointment in Acute Cardiopulmonary Edema
Authors: PREDIMAN K. SHAH
Journal: Annals of Internal Medicine (1985)

Letters and Corrections1 July 1985Buccal Nitroglycerin Ointment in Acute Cardiopulmonary EdemaPREDIMAN K. SHAH, M.D.PREDIMAN K. SHAH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-1-153_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Nitrates administered sublingually or intravenously generally produce prompt reduction in pulmonary capillary wedge pressure due to their venodilator effects and are thus a mainstay of the emergency management of acute pulmonary edema (1). We have recently seen three patients who remained in severe symptomatic pulmonary edema despite rapidly increasing doses of intravenous nitroglycerin, several doses of sublingual nitroglycerin, morphine, and large doses of diuretic agents but showed prompt and dramatic improvement after buccal application of half an inch of 2% nitroglycerin ointment (approximately 7.5 mg).A 76-year-old white woman was admitted to our cardiac intensive care unit...References1. BUSSMAN W and SCHUPP D. Effect of sublingual nitroglycerin in emergency treatment of severe pulmonary edema. Am J Cardiol. 1978;41:931-6. CrossrefMedlineGoogle Scholar2. NOONAN P and BENET L. Incomplete and delayed bioavailability of sublingual nitroglycerin. Am J Cardiol. 1985;55:184-7. CrossrefMedlineGoogle Scholar3. DAVIS S, DALY P, KENNERLY J, FRIER M, HARDY J, and WILSON C. Design and formulation of sustained release formulations for oral and buccal administration. In: STILLE G, WAGNER W, HERRMANN WM, eds. Advances in Pharmacotherapy. New York; S. Karger; 1982:17-25. Google Scholar4. COSSUM P, GALBRAITH A, and ROBERTS M. Loss of nitroglycerin from intravenous infusion sets. Lancet. 1978;2:249-50. MedlineGoogle Scholar5. CHARUZI Y. Use of nitroglycerin ointment in acute pulmonary edema and hypertension [Letter]. Chest. 1982;82:800. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PREDIMAN K. SHAH, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byComplicated Acute Myocardial Infarction: Heart Failure, Shock, Mechanical ComplicationsNitratesUse of Nitrates TodayBuccal Nitroglycerin Tablets in Heart FailureAVIJIT LAHIRI, M.B., B.S. M.SC., GIAN PIERO CARBONI, M.D., EDWARD B. RAFTERY, M.D. 1 July 1985Volume 103, Issue 1Page: 153-154KeywordsCardiac care unitDiureticsEdemaMorphineNitratesOintmentsPulmonary capillary wedge ePublished: 1 December 2008 Issue Published: 1 July 1985 PDF downloadLoading ...
Transthyretin-related amyloidoses and the heart: a clinical overview
Authors: Claudio Rapezzi, Candida Cristina Quarta, Letizia Riva, Simone Longhi, Ilaria Gallelli, Massimiliano Lorenzini, Paolo Ciliberti, Elena Biagini, Fabrizio Salvi, Angelo Branzi
Journal: Nature Reviews Cardiology (2010)
Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones
Authors: Lily Chao, Bernice Marcus-Samuels, Mark M. Mason, Jaideep Moitra, Charles Vinson, Elif Arioglu, Oksana Gavrilova, Marc L. Reitman
Journal: Journal of Clinical Investigation (2000)

There is uncertainty about the site(s) of action of the antidiabetic thiazolidinediones (TZDs). These drugs are agonist ligands of the transcription factor PPARγ, which is abundant in adipose tissue but is normally present at very low levels in liver and muscle. We have studied the effects of TZDs in A-ZIP/F-1 mice, which lack white adipose tissue. The A-ZIP/F-1 phenotype strikingly resembles that of humans with severe lipoatrophic diabetes, including the lack of fat, marked insulin resistance and hyperglycemia, hyperlipidemia, and fatty liver. Rosiglitazone or troglitazone treatment did not reduce glucose or insulin levels, suggesting that white adipose tissue is required for the antidiabetic effects of TZDs. However, TZD treatment was effective in lowering circulating triglycerides and increasing whole body fatty acid oxidation in the A-ZIP/F-1 mice, indicating that this effect occurs via targets other than white adipose tissue. A-ZIP/F-1 mice have markedly increased liver PPARγ mRNA levels, which may be a general property of fatty livers. Rosiglitazone treatment increased the triglyceride content of the steatotic livers of A-ZIP/F-1 and ob/ob mice, but not the "lean" livers of fat-transplanted A-ZIP/F-1 mice. In light of this evidence that rosiglitazone acts differently in steatotic livers, the effects of rosiglitazone, particularly on hepatic triglyceride levels, should be examined in humans with hepatic steatosis.
CASE OF INFECTION WITH THE RAT-TAILED LARVA OF THE DRONE FLY.
Authors: E. L. K. HANBY
Journal: JAMA (1905)

Dr. Boston, Philadelphia, found on postmortem in a child which died in convulsions and great agony a parasite, which he sent to Professor Stiles of Washington, D. C., who replied that the specimen was a species of the genus<i>Helophilus or Eristalis</i>. Dr. Boston gives no history or treatment of his case further than that the child died in great agony and convulsions. With the exception of this case I fail to find that any other author mentions this species of parasite. I feel that this disease is very grave and that perhaps it is often met without being recognized. The case which I wish to report came under my personal observation, and the pain and agony was something terrible. I have never seen any human being suffer more than did this child. <h3>History.</h3> —On Sept. 12, 1905, I was called to see a little negress 18 months old, at
Early "Step-Down" Transfer of Low-Risk Patients with Chest Pain
Authors: Scott Weingarten
Journal: Annals of Internal Medicine (1990)

Objective: To determine whether providing private practitioners with triage criteria for their low-risk chest pain patients would safely enhance bed utilization efficiency in coronary and intermediate care units. Design: Prospective, controlled, interventional trial using an alternate month study design. Setting: A large teaching community hospital. Patients: Cohort of 404 low-risk patients with chest pain for whom a diagnosis of myocardial infarction has been excluded and who have not sustained complications, required interventions, or developed unstable comorbidity. Interventions: During intervention months, private practitioners caring for low-risk patients in the coronary and intermediate care units were contacted 24 hours after admission. Physicians were informed that the transfer of low-risk patients to nonmonitored beds could probably be done safely, based on the results of a pilot study. The practitioner had the option of agreeing to or deferring patient transfer. During control months, physicians were not contacted in this way. Measurements and Main Results: Use of the triage criteria by private practitioners reduced lengths of stay in the intermediate and coronary care units by 36% and 53%, respectively. Bed availability increased by 744 intermediate and 372 coronary care unit bed-days per year. Charges decreased by $2.6 million per year and profits improved by $390 000 per year. There were no significant differences in complications between control and intervention patients and in no case (95% CI, 0% to 1.6%) did the triage criteria adversely affect quality of care. Conclusions: The early transfer triage criteria may be a safe and efficacious decision aid for improving bed utilization in intermediate and coronary care units. In addition, this study shows the feasibility of and potential benefits from applying practice guidelines at a community hospital.
Utility of Gene Rearrangements in Lymphoid Malignancies
Authors: A C Aisenberg
Journal: Annual Review of Medicine (1993)

CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and re-educate macrophages to destroy tumor stroma. Numerous agonist CD40 ...Read More