AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATT
Authors: AUGUSTUS WADSWORTH
Journal: Annals of Internal Medicine (1937)

Article1 November 1937AN ARTICLE CONTRIBUTED TO AN ANNIVERSARY VOLUME IN HONOR OF DOCTOR JOSEPH HERSEY PRATTSOME OF THE PRACTICAL PROBLEMS IN THE SERUM THERAPY OF BACTERIAL INFECTIONS*AUGUSTUS WADSWORTHAUGUSTUS WADSWORTHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-11-5-791 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSerum therapy is an outgrowth of the discovery that microörganisms, the bacteria, are incitants of infectious disease. As such, it is difficult to differentiate the results of the branch from those of the parent stem. For example, in diphtheria, early diagnosis with prompt isolation has alone had a far-reaching effect not only upon the morbidity but also, indirectly, upon the severity of the disease; and it is difficult to distinguish the effect of the discovery of the diphtheria bacillus and of improved public health methods from that of the specific treatment with antitoxin, on the morbidity and mortality of the...Bibliography1. WADSWORTH AB: Studies on pneumococcus infection in animals. Second paper: Action of immune sera on pneumococcus infection, Jr. Exper. Med., 1912, xvi, 78-102. CrossrefGoogle Scholar2. MILLERCASTLES CPR: Experimental meningococcal infection in the mouse, Jr. Infect. Dis., 1936, lviii, 263-279. CrossrefGoogle Scholar3. COHEN SM: A study of the virulence of meningococcus strains and of the protective activity of antimeningococcus sera, Jr. Immunol., 1936, xxx, 203-212. Google Scholar4. MISHULOWMELMAN LM: A mouse protection test for standardizing antimeningococcus serums, Jr. Lab. and Clin. Med., 1936, xxi, 406-411. Google Scholar5. RAKE G: A method for titrating the protective action of antimeningococcal serum, Proc. Soc. Exper. Biol. and Med., 1935, xxxii, 1175-1178. CrossrefGoogle Scholar6. FERRYNORTONSTEELE NSJFAH: Studies of the properties of bouillon filtrates of the meningococcus: Production of a soluble toxin, Jr. Immunol., 1931, xxi, 293-312. Google Scholar7. : Cerebrospinal fever. Studies in the bacteriology, preventive control, and specific treatment of cerebrospinal fever among the military forces, 1915-19, By M. H. Gordon; Medical Research Council Special Report Series, No. 50, London, His Majesty's Stationery Office, 1920, 205 pp. Google Scholar8. : The meningococcus, by E. G. D. Murray; Medical Research Council Special Report Series, No. 124, London, His Majesty's Stationery Office, 1929, 142 pp. Google Scholar9. FERRYSCHORNACK NSPJ: Meningococcus toxin and antitoxin. IV. Further tests on guinea pigs and rabbits, Jr. Immunol., 1934, xxvi, 143-160. Google Scholar10. BRANHAMPABSTLILLIE SEAMRD: Serum studies in experimental meningococcus infection: lack of protection for rabbits and guinea pigs, (Soc. Proc.) Jr. Bact., 1936, xxxi, 40. Google Scholar11. MAEGRAITH BG: Immunity to meningococcus, Report of Proceedings, Second Internat. Congr. for Microbiol., London, 1937, pp. 531-532. Google Scholar12. PETRIE GF: The endotoxin of the meningococcus, Jr. Hyg., 1937, xxxvii, 42-69. CrossrefGoogle Scholar13. KIRKBRIDECOHEN MBSM: Comparative titrations of antimeningococcus sera produced with living cells and broth filtrates. (To be published in the Journal of Immunology.) Google Scholar14. WHEELER MW: Notes on the antigenic activity of hemolytic streptococci from different types of infection, Jr. Immunol., 1932, xxiii, 311-314. Google Scholar15. WADSWORTHCOFFEY AJM: The toxigenic properties of hemolytic streptococci from human infections, Jr. Immunol., 1935, xxix, 505-510. Google Scholar16. DOCHEZAVERYLANCEFIELD AROTRC: Studies on the biology of streptococcus. I. Antigenic relationships between strains of Streptococcus haemolyticus , Jr. Exper. Med., 1919, xxx, 179-213. CrossrefGoogle Scholar17. LANCEFIELD RC: The antigenic complex of Streptococcus haemolyticus. I. Demonstration of a type-specific substance in extracts of Streptococcus haemolyticus , Jr. Exper. Med., 1928, xlvii, 91-103. CrossrefGoogle Scholar18. LANCEFIELD RC: A serological differentiation of human and other groups of hemolytic streptococci, Jr. Exper. Med., 1933, lvii, 571-595. CrossrefGoogle Scholar19. GRIFFITH F: The serological classification of Streptococcus pyogenes , Jr. Hyg., 1934, xxxiv, 542-584. Google Scholar20. BLAKETRASK FGJD: Observations on therapeutic value of scarlatinal antitoxin, N. Y. State Jr. Med., 1925, xxv, 1093-1099. Google Scholar21. WADSWORTH A: Recent advances in the serum therapy of pneumonia, meningitis, scarlet fever and other streptococcus infections, Trans. Assoc. Am. Phys., 1932, xlvii, 161-176. Google Scholar22. WADSWORTHKIRKBRIDEHENDRY ABMBJL: A comparative study of the potency and polyvalency of antistreptococcus serum used in the treatment of scarlet fever, Am. Jr. Hyg., 1929, ix, 371-388. Google Scholar23. WHEELER MW: Observations on streptococcus toxin-antitoxin neutralization as a basis for specificity, Proc. Soc. Exper. Biol. and Med., 1930, xxvii, 570-573. CrossrefGoogle Scholar24. TRASKBLAKE JDFG: Heterologous scarlet fever, Jr. Am. Med. Assoc., 1933, ci, 753-755. CrossrefGoogle Scholar25. FRASER FH: The diversity of the toxins produced by various strains of hemolytic streptococci from scarlatinal and non-scarlatinal sources, Trans. Roy. Soc. Canada, 1934, xxviii, Sec. V, 81-90. Google Scholar26. FRASERPLUMMER FHHC: Neutralizing action of two streptococcal antisera, Trans. Roy. Soc. Canada, 1935, xxix, Sec. V, 63-68. Google Scholar27. WADSWORTH A: The bacteria as incitants of malignant endocarditis, Med. Record, 1907, lxii, 1059-1074. Google Scholar28. WADSWORTH AB: Studies on pneumococcus infection in animals. First paper, Jr. Exper. Med., 1912, xvi, 54-77. CrossrefGoogle Scholar29. WADSWORTH AB: Studies on pneumococcus infection in animals, Trans. Assoc. Am. Phys., 1912, xxvii, 72-81. Google Scholar30. WADSWORTHGILBERTHUTTON ABRA: Study of the classification of meningococci, Jr. Exper. Med., 1921, xxxiii, 99-105. CrossrefGoogle Scholar31. WADSWORTH A: Meningococcus meningitis: The results of recent investigation in relation to serum therapy, Am. Jr. Hyg., 1931, xiv, 630-654. Google Scholar32. KIRKBRIDECOHEN MBSM: Observations on the serological and immunological reactions of meningococcus strains in relation to serum production, Am. Jr. Hyg., 1932, xv, 444-458. Google Scholar33. PETRIE GF: A specific precipitin reaction associated with the growth on agar plates of meningococcus, pneumococcus, and B. dysenteriae (Shiga), Brit. Jr. Exper. Path., 1932, xiii, 380-394. Google Scholar34. KIRKBRIDECOHEN MBSM: Precipitation reactions of meningococcus strains with immune serum in agar plates in relation to antigenic activity, Am. Jr. Hyg., 1934, xx, 444-453. Google Scholar35. RAKESCHERP GHW: Studies on meningococcus infection. III. The antigenic complex of the meningococcus—a type-specific substance, Jr. Exper. Med., 1933, lviii, 341-360. CrossrefGoogle Scholar36. SHWARTZMAN G: Therapeutic antimeningococcus serums. Their neutralizing potency as measured by the phenomenon of local skin reactivity, Jr. Infect. Dis., 1931, xlviii, 339-349. CrossrefGoogle Scholar37. SICKLES GM: The standardization of antimeningococcus serum: The titration of its neutralizing potency by the phenomenon of local skin reactivity, Am. Jr. Hyg., 1933, xvii, 412-431. Google Scholar38. BRANHAMLILLIE SERD: Observations on experimental meningitis in rabbits, Pub. Health Rep., 1932, xlvii, 2137-2150. CrossrefGoogle Scholar39. RAKE G: Viability and virulence of frozen and dried cultures of meningococcus, Proc. Soc. Exper. Biol. and Med., 1935, xxxii, 975-977. CrossrefGoogle Scholar40. PABST AM: Use of below-freezing temperatures for maintenance of meningococcus cultures (Neisseria intracellularis Weichselbaum), Pub. Health Rep., 1935, l, 732-737. CrossrefGoogle Scholar41. KIRKBRIDECOHEN MBSM: The relative potency of monovalent and polyvalent antimeningococcus sera. (To be published in the American Journal of Hygiene.) Google Scholar42. MURDICKCOHEN PPSM: A note on the fractionation of antimeningococcus serum, Jr. Immunol., 1933, xxiv, 531-541. Google Scholar43. MURDICKCOHEN PPSM: A note on the concentration and purification of antimeningococcus serum, Jr. Immunol., 1935, xxviii, 205-208. Google Scholar44. KIRKBRIDEHENDRYMURDICK MBJLPP: The concentration and standardization of type-I antipneumococcus serum, Am. Jr. Hyg., 1936, xxiii, 187-204. Google Scholar45. ABERNETHY TJ: Concentrated antipneumococcus serum in type I pneumonia. Control of dosage by skin tests with type-specific polysaccharide, N. Y. State Jr. Med., 1936, xxxvi, 627-634. Google Scholar46. COLE R: Serum treatment in type I lobar pneumonia, Jr. Am. Med. Assoc., 1929, xciii, 741-747. CrossrefGoogle Scholar47. TILLETTBROWN WSTM: Epidemic meningococcus meningitis. An analysis of twenty-six cases, twenty-one of which occurred in the spring of 1935, Bull. Johns Hopkins Hosp., 1935, lvii, 297-316. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Albany, N. Y.*Received for publication July 15, 1937.From the Division of Laboratories and Research, New York State Department of Health, Albany. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1937Volume 11, Issue 5Page: 791-800KeywordsAntitoxinsBacillusBacteriaDiphtheriaInfectious diseasesMorbidityMortalityPrevention, policy, and public healthResearch laboratoriesSerotherapy Issue Published: 1 November 1937 PDF DownloadLoading ...