An Autoregulatory Effect of Iodide in Diverse Thyroid Disorders
Authors: HERBERT A. SELENKOW
Journal: Annals of Internal Medicine (1965)

Article1 April 1965An Autoregulatory Effect of Iodide in Diverse Thyroid DisordersHERBERT A. SELENKOW, M.D., F.A.C.P., ANTONIO M. GARCIA, M.D., EDWARD B. BRADLEY, M.D.HERBERT A. SELENKOW, M.D., F.A.C.P.Search for more papers by this author, ANTONIO M. GARCIA, M.D.Search for more papers by this author, EDWARD B. BRADLEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-4-714 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the past, clinical observations on the effects of iodide in diverse thyroidal diseases have appeared quite paradoxic. For example, high doses are known to produce both goiter and hypothyroidism in some individuals, whereas in others, iodide is used therapeutically to correct goiter as well as hypothyroidism. In Graves' disease, iodide is given to inhibit excess thyroid hormone synthesis and thus ameliorate thyrotoxicosis; yet in some iodide-deficient goiters, it has been known to enhance thyroid hormone secretion to induce thyrotoxicosis (Jod-Basedow). These seemingly contradictory phenomena have been studied extensively and reviewed (1) but still remain enigmatic.The role of iodide...References1. WOLFF J: Transport of iodide and other anions in the thyroid gland. Physiol. Rev. 44: 45, 1964. CrossrefMedlineGoogle Scholar2. HAMILTON JG: The use of radioactive tracers in biology and medicine. Radiology 39: 541, 1942. CrossrefGoogle Scholar3. MORTONCHAIKOFFROSENFELD MEILS: Inhibiting effect of inorganic iodide on the formation in vitro of thyroxine and diiodotyrosine by surviving thyroid tissue. J. Biol. Chem. 154: 381, 1944. CrossrefGoogle Scholar4. WOLFFCHAIKOFF JIL: Plasma inorganic iodide as a homeostatic regulatory of thyroid function. J. Biol. Chem. 174: 555, 1948. CrossrefMedlineGoogle Scholar5. STANLEY MM: The direct estimation of the rate of thyroid hormone formation in man. The effect of the iodide on thyroid iodine utilization. J. Clin. Endocr. 9: 941, 1949. CrossrefGoogle Scholar6. WOLFFCHAIKOFFGOLDBERGMEIER JILRCJR: The temporary nature of the inhibiting action of excess iodide on organic iodine synthesis in the normal thyroid. Endocrinology 45: 504, 1949. CrossrefMedlineGoogle Scholar7. RABEN MS: The paradoxical effects of thiocyanate and of thyrotropin on the organic binding of iodine by the thyroid in the presence of large amounts of iodide. Ibid., p. 296. Google Scholar8. CHILDSKEATINGRALLWILLIAMSPOWER DSFRJEMMMH: The effect of varying quantities of inorganic iodide (carrier) on the urinary excretion and thyroidal accumulation of radio-iodine in exophthalmic goiter. J. Clin. Invest. 29: 726, 1950. CrossrefMedlineGoogle Scholar9. FEINBERGHOFFMANOWEN WDDLCA: The effects of varying amounts of stable iodide on the function of the human thyroid. J. Clin. Endocr. 19: 567, 1959. CrossrefGoogle Scholar10. WAGNERNELPDOWLING HNWBJH: Use of neutron activation analysis for studying stable iodide uptake by the thyroid. J. Clin. Invest. 40: 1984, 1961. CrossrefMedlineGoogle Scholar11. PARISMCCONANEYTAUXEWOOLNERBAHN JWMWNLBRC: The effect of iodides on Hashimoto's thyroiditis. J. Clin. Endocr. 21: 1037, 1961. CrossrefGoogle Scholar12. MORGANSTROTTER MEWR: Defective organic binding of iodine by the thyroid in Hashimoto's thyroiditis. Lancet 1: 553, 1957. CrossrefGoogle Scholar13. STANBURYHEDGE JBAN: A study of a family of goitrous cretins. J. Clin. Endocr. 10: 1471, 1950. CrossrefGoogle Scholar14. BUCHANANKOUTRASALEXANDERCROOKSRICHMONDMACDONALDWAYNE WWDAWDJMHEMEJ: Iodine metabolism in Hashimoto's thyroiditis. J. Clin. Endocr. 21: 806, 1961. CrossrefGoogle Scholar15. FLOYDBEIERWALTESDODSONCARR JCWHVNEA: Defective iodination of tyrosine. A cause of nodular goiter? J. Clin. Endocr. 20: 881, 1960. CrossrefGoogle Scholar16. KILPATRICKWILSON RGM: Simple non-toxic goitre, in The Thyroid Gland, Vol. 2, edited by PITT-RIVERS, R., and TROTTER, W. R. Butterworths, Washington, 1964, pp. 88-111. Google Scholar17. BRAVERMANINGBAR LESH: Changes in thyroidal function during adaptation to large doses of iodide. J. Clin. Invest. 42: 1216, 1963. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, MassachusettsFrom the Department of Medicine, Harvard Medical School, and The Clinical Center, Peter Bent Brigham Hospital, Boston, Mass.This study was supported by grant 8M01-Fr31-04 and in part by the Endocrine Training Grant T1-AM-4100 from the U. S. Public Health Service, Bethesda, Md., and a grant for Immunologic Investigation from the John A. Hartford Foundation, N. Y.Portions of this study were presented at the 45th Annual Meeting of the American College of Physicians, Atlantic City, N. J., April 6-10, 1964.Requests for reprints should be addressed to Herbert A. Selenkow, M.D., Peter Bent Brigham Hospital, 721 Huntington Avenue, Boston, Mass. 02115. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAmiodarone and thyroid physiology, pathophysiology, diagnosis and managementIncidence and Pattern of Thyroid Dysfunction in Patients on Chronic Amiodarone Therapy: Experience at a Tertiary Care Centre in Oman131I treatment of thyroid papillary carcinoma in a patient with renal failureIodide-induced hypothyroidism in patients after thyroid resectionCYCLIC NUCLEOTIDES IN THYROID HORMONE SECRETIONBiosynthesis of thyroid hormone: Basic and clinical aspectsThyroid peroxidase-catalyzed iodination of thyroglobulin; inhibition by excess iodideThyroid Peroxidase and Thyroxine BiosynthesisIodide goiter and the pharmacologic effects of excess iodideIodine Disinfection of WaterPATHOGENESIS OF HYPERTHYROIDISM DUAL ROLE OF IODINE IN THYROID FUNCTIONBIBLIOGRAPHY 1 April 1965Volume 62, Issue 4Page: 714-726KeywordsHormone synthesisHospital medicineHypothyroidismMedical servicesThyroidThyroid diseasesThyroid hormones Issue Published: 1 April 1965 PDF downloadLoading ...