Hepatitis C Virus Not Found in Fulminant Non-A, Non-B Hepatitis
Authors: Teresa L. Wright, Henry Hsu, Elizabeth Donegan, Stephen Feinstone, Harry Greenberg, Alexandra Read, Nancy L. Ascher, John P. Roberts, John R. Lake
Journal: Annals of Internal Medicine (1991)

Brief Reports15 July 1991Hepatitis C Virus Not Found in Fulminant Non-A, Non-B HepatitisTeresa L. Wright, MD, Henry Hsu, MD, Elizabeth Donegan, MD, Stephen Feinstone, MD, Harry Greenberg, MD, Alexandra Read, MD, Nancy L. Ascher, MD, John P. Roberts, MD, John R. Lake, MDTeresa L. Wright, MD, Henry Hsu, MD, Elizabeth Donegan, MD, Stephen Feinstone, MD, Harry Greenberg, MD, Alexandra Read, MD, Nancy L. Ascher, MD, John P. Roberts, MD, John R. Lake, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-2-111 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptNon-A, non-B hepatitis is a diagnosis of exclusion in patients with acute hepatitis but without serologic evidence of hepatitis A or hepatitis B viral infection. The recently identified hepatitis C virus (HCV) accounts for most cases of non-A, non-B hepatitis after blood transfusion or intravenous drug abuse (1, 2). However, it is not known whether HCV causes fulminant non-A, non-B hepatitis. To address this issue, we used a sensitive and specific polymerase chain reaction to detect HCV RNA in patients with fulminant hepatic failure of unknown cause.Patients and MethodsWe studied 15 patients who were referred for liver transplantation...References1. AlterPurcellShih HRJ. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N Engl J Med. 1989;321:1494-500. CrossrefMedlineGoogle Scholar2. KuoChooAlter GQH. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science. 1989;244:362-4. CrossrefMedlineGoogle Scholar3. CristianoDi BisceglieHoofnagleFeinstone KAJS. Hepatitis C viral RNA in serum of patients with chronic non-A, non-B hepatitis: detection by polymerase chain reaction using multiple primer sets. Hepatology. [In press]. Google Scholar4. O'GradyAlexanderHayllarWilliams JJKR. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology. 1989;97:439-45. CrossrefMedlineGoogle Scholar5. Dienstag J. Non-A, non-B hepatitis I. Recognition, epidemiology, and clinical features. Gastroenterology. 1983;85:439-62. CrossrefMedlineGoogle Scholar6. BernuauRueffBenhamou JBJ. Fulminant and subfulminant liver failure: definitions and causes. Semin Liv Dis. 1986;6:97-106. CrossrefMedlineGoogle Scholar7. MutoSugiharaOhnishiMoriwakiNishioka YJHHK. Anti-hepatitis C virus antibody prevails in fulminant hepatic failure. Gastroenterol Jpn. 1990;25:32-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Teresa L. Wright, MD; Henry Hsu, MD; Elizabeth Donegan, MD; Stephen Feinstone, MD; Harry Greenberg, MD; Alexandra Read, MD; Nancy L. Ascher, MD; John P. Roberts, MD; John R. Lake, MDAffiliations: From the Department of Veterans Affairs Medical Center and the University of California, San Francisco, San Francisco, California; Palo Alto Department of Veterans Affairs Medical Center, Palo Alto, California; Stanford University, Stanford, California; and the Laboratory of Hepatitis Research, Food and Drug Administration, Bethesda, Maryland. For current author addresses, see end of text. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAcute Liver FailureLiver transplantation in patients with fulminant hepatitisHepatitis CAnimal Models of Hepatitis C Virus InfectionNatural history of HCV infectionAcute Liver FailureLiver transplantation in patients with fulminant hepatitisAn overview about hepatitis C: A devastating virusHepatitis C VirusHepatitis CTropical Infections in Critical Care The views expressed in this chapter are those of the authors and do not reflect the official policy of the Department of Army, Navy, Department of Defense, or US government.Tropical Infections in Critical Care The views expressed in this chapter are those of the authors and do not reflect the official policy of the Department of Army, Navy, Department of Defense, or US government.Hepatitis C virus JFH-1 strain infection in chimpanzees is associated with low pathogenicity and emergence of an adaptive mutationIn Vivo Study of the HC-TN Strain of Hepatitis C Virus Recovered from a Patient with Fulminant Hepatitis: RNA Transcripts of a Molecular Clone (pHC-TN) Are Infectious in Chimpanzees but Not in Huh7.5 CellsLiver Transplantation in Patients with Fulminant HepatitisAcute Liver FailureFulminant hepatic failureClinical, histologic and serologic evaluation of patients with acute non-A-E hepatitis in north-eastern Brazil: is it an infectious disease?Case fatality rate of acute viral hepatitis in Italy: 1995–2000. An updateNon-A to E hepatitisHCV infection and hemodialysisInfection in the Organ Transplant RecipientImmunopathogenesis of hepatitis C virus infectionHepatitis activity index is a key factor in determining the natural history of chronic hepatitis CSequence analysis of hepatitis C virus isolated from a fulminant hepatitis patientHVR1 quasispecies analysis from a long-term culture of hepatitis C virus in Hep G2 derived cells grown in a haemodialysis cartridgeHuman Immunodeficiency Virus and Other Occupational Exposures: Risk ManagementAcute liver failure: Established and putative hepatitis viruses and therapeutic implicationsAcute hepatic failure: A Western perspectiveTT virus infection: An emerging pathogen in search of its identityWhat do we need to know about nonA—to-E viral hepatitis?¿Qué son las enfermedades hepáticas criptogenéticas?Prevalence of TT virus DNA in eastern Taiwan aboriginesThe Significance of Hepatitis G Virus in Serum of Patients With Sporadic Fulminant and Subfulminant Hepatitis of Unknown EtiologyThe Significance of Hepatitis G Virus in Serum of Patients With Sporadic Fulminant and Subfulminant Hepatitis of Unknown EtiologyAcute sporadic non-A, non-B hepatitis in Northeastern Brazil: Etiology and natural historyFULMINANT HEPATIC FAILUREVIRAL HEPATITIS IN PREGNANCYRisk of Transfusion-Transmitted Infection: A Comparative Analysis of Then and NowThe distribution of HBV, HCV and HGV among livers with fulminant hepatic failure of different aetiologyFULMINANT HEPATITIS CAUSED BY HEPATITIS C VIRUSFecal excretion of a nonenveloped DNA virus (TTV) associated with posttransfusion non-A-G hepatitisHepatitis C virus infectionChronic hepatitis C: the virus, its discovery and the natural history of the diseaseDetection of hepatitis C and E virus genomes in sera of patients with acute viral hepatitis and fulminant hepatitis by their simultaneous amplification in PCRRecent Progress in the Treatment of Fulminant Hepatic Failure in JapanLa biologie du virus de l'hépatite C: les implications cliniquesNon-A, non-B, non-C hepatitis: Its significance in pediatric patients and the role of GB virus-CHow important is hepatitis C virus (HCV)-infection in persons with acute leukemia?SELECTION OF PROGNOSTIC FACTORS OF ACUTE HEPATITIS TYPE NON-A, NON-B FOR PATIENT LISTING FOR LIVER TRANSPLANTATION1Fulminant hepatic failureInfection with GB virus C in patients with chronic liver diseaseThe quasispecies of hepatitis C virus and the host immune responseDiscovery of Hepatitis G VirusViral HepatitisHepatitis CCase Fatality Rate of Acute Hepatitis in Italy: Results from a 10 Year SurveillanceHepatitis C virusHepatitis C virus density heterogeneity and viral titre in acute and chronic infection: a comparison of immunodeficient and immunocompetent patientsHepatitis C Virus–Associated Fulminant Hepatic FailureNew hepatitis virusesHepatitis B and C viruses and primary liver cancerFulminant hepatitis in patients undergoing liver transplantation: Evidence for a non-A, non-B, non-C, non-D, and non-E syndromeFulminant hepatitis caused by hepatitis C virus during treatment for multiple sclerosisFulminant hepatitis on withdrawal of chemotherapy in carriers of hepatitis C virusHepatitis C virus infection: clinical aspects and treatment with interferon alfaParvovirus B19 as a possible causative agent of fulminant liver failure and associated aplastic anemiaDetection of hepatitis C virus with RNA polymerase chain reaction in fulminant hepatic failureVirus de l'hépatite C : structure et variabilité génétiqueThe management of chronic hepatitis C virus infection.Hepatitis C and liver transplantationFulminant Hepatic FailureFULMINANT VIRAL HEPATITISFailure to incriminate hepatitis B, hepatitis C, and hepatitis E viruses in the aetiology of fulminant non-A non-B hepatitis.Evidence of non-A, non-B, non-C infection in chronic hepatitis by polymerase chain raction testing for hepatitis B and C virusesHEPATITIS C: An OverviewInterferon and cyclosporin A in the treatment of fulminant viral hepatitisMolecular Detection of Hepatitis C Virus: Impact of Detection Methodology on Clinical and Laboratory CorrelationsThe course of hepatitis C virus infection after liver transplantationAplastic anemia after liver transplantation for fulminant liver failureHepatitis C: progress and problemsScreening and confirmatory testing of cadaver organ donors for hepatitis C virus infection: A U.S. National Collaborative StudySequence variability of hepatitis C virus and its clinical relevanceThe role of hepatitis C virus in fulminant viral hepatitis in an area with endemic hepatitis A and BAcute liver failure of unknown pathogenesis: The hidden agendaContribution of hepatitis C virus to non-A, non-B fulminant hepatitis in JapanChronic hepatitis CLack of Evidence for Hepatitis C Virus in Corneas of Seropositive CadaversFatal acute hepatic necrosis due to fluconazoleEtiological role of hepatitis E virus in sporadic fulminant hepatitisHepatitis C Viral Infection after Orthotopic Liver TransplantationInfection in the Organ Transplant RecipientClinical and Laboratory Features of Acute Community-acquired Non-A, Non-B, Non-C HepatitisGenotype of hepatitis C virus in fulminat hepatitis CHepatitis C and E in non-A non-B fulminant hepatic failure: a polymerase chain reaction and serological studyImportance of the polymerase chain reaction in the study of hepatitis C virus infectionDiagnosis and Treatment of the Major Hepatotropic VirusesFulminant hepatic failureMinimal role of hepatitis C virus infection in childhood liver diseases in an area hyperendemic for hepatitis B infectionLIVER TRANSPLANTATION FOR CHRONIC HEPATITIS C VIRAL INFECTIONLIVER TRANSPLANTATION FOR FULMINANT HEPATIC FAILUREChronic hepatitisHepatitis C virus RNA and hepatitis B virus DNA in serum and liver of patients with fulminant hepatitisFulminant or subfulminant non-A, non-B viral hepatitis: The role of hepatitis C and E virusesEtiology of fulminant hepatic failure: Is another virus involved?Inactivation of Viruses during Ultraviolet Light Treatment of Human Intravenous Immunoglobulin and AlbuminRole of hepatitis C virus infection in German patients with fulminant and subacute hepatic failureRecurrent and acquired hepatitis C viral infection in liver transplant recipientsInfectious diseases and AIDSHepatitis B virus and apparent fulminant non-A, non-B hepatitisHepatitis C Virus and Fulminant HepatitisJames W. Mosley, MD, Jorge Rakela, MD 15 July 1991Volume 115, Issue 2Page: 111-112KeywordsFood and Drug AdministrationHepatitisHepatitis AHepatitis BHepatitis C virusLiver transplantationPolymerase chain reactionRNARenal diseasesResearch laboratories ePublished: 1 December 2008 Issue Published: 15 July 1991 PDF downloadLoading ...