Hepatotoxicity Due to Treatment With Verapamil
Authors: SAMUEL J. BRODSKY
Journal: Annals of Internal Medicine (1981)

Brief Reports1 April 1981Hepatotoxicity Due to Treatment With VerapamilSAMUEL J. BRODSKY, M.D., SALLY S. CUTLER, B.S., DONALD A. WEINER, M.D., MICHAEL D. KLEIN, M.D.SAMUEL J. BRODSKY, M.D., SALLY S. CUTLER, B.S., DONALD A. WEINER, M.D., MICHAEL D. KLEIN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-4-490 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVerapamil hydrochloride (Isoptin; Knoll Pharmaceuticals, Whippany, New Jersey), a papaverine derivative currently being tested experimentally in the United States, is a calcium channel blocking agent used for treatment of angina pectoris (1, 2), supraventricular arrhythmias (3, 4), and subaortic stenosis (5). Reported adverse effects from verapamil include: hypotension (4, 6), negative inotroppy (6), atrioventricular block (7), and mild nausea and constipation (1). We describe a case of verapamil induced hepatotoxicity.A 55-year-old white man with Class II exertional angina consented to a double-blind serial treadmill exercise test protocol to evaluate the anti-anginal efficacy of verapamil. Prior cardiac catheterization showed a...References1. SANDLER G, CLAYTON G, and THORNICROFT S. Clinical evaluation of Verapamil in angina pectoris. Br Med J. 1968;3:224-7. CrossrefMedlineGoogle Scholar2. LIVESLEY B, CATLEY P, CAMPBELL R, and ORAM S. Double-blind evaluation of verapamil, propranolol and isosorbide dinitrate against a placebo in the treatment of angina pectoris. Br Med J 1973;1:375-8. CrossrefMedlineGoogle Scholar3. KRIKLER D and SPURRELL R. Verapamil in the treatment of paroxysmal supraventricular tachycardia. Postgrad Med J. 1974;50:447-53. CrossrefMedlineGoogle Scholar4. SCHAMROTH L. Immediate effects of intravenous Verapamil on atrial fibrillation. Cardiovasc Res 1971;5:419-24. CrossrefMedlineGoogle Scholar5. ROSING D, KENT K, MARON B, and EPSTEIN S. Verapamil therapy: A new approach to the pharmacologic treatment of hypertrophic cardiomyopathy. II. Effects on exercise capacity and symptomatic status. Circulation. 1979;60(6):1208-13. CrossrefMedlineGoogle Scholar6. LEWIS B, MITHA A, and GOTSMAN M. Immediate hemodynamic effects of Verapamil in man. Cardiology. 1975;60:366-76. CrossrefMedlineGoogle Scholar7. HUSAINI M, KVASNICKA J, RYDÉN L, and HOLMBERG S. Action of Verapamil on sinus node, atrioventricular, and intraventricular conduction. Br Heart J. 1973;35:734-7. CrossrefMedlineGoogle Scholar8. R0NNOV-JESSEN V and TJERNLUND A. Hepatotoxicity due to treatment with papaverine. N Engl J Med. 1969;281:1333-5. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SAMUEL J. BRODSKY, M.D.; SALLY S. CUTLER, B.S.; DONALD A. WEINER, M.D.; MICHAEL D. KLEIN, M.D.Affiliations: Boston University Medical Center Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFulminant Chemical Hepatitis Possibly Associated with Donepezil and Sertraline TherapyCa2+ antagonists do not protect isolated perfused rat hepatocytes from anoxic injuryTypes, causes, and therapies of hepatitis occurring in liver transplant recipientsProbleme bei der Behandlung mit KalziumantagonistenCardiac drug toxicity: digitalis glycosides and calcium‐channel and β‐blocking agentsDrug-induced Liver DiseaseSide Effects and Contraindications Drug Interactions and CombinationsAcute Drug-Induced Hepatic InjuryCalcium channel antagonists part IV: Side effects and contraindications drug interactions and combinationsNebenwirkungen — Überdosierung (Vergiftung) — Kontraindikationen — ArzneimittelinteraktionenMassive diltiazem overdoseCalcium Channel blockers: Spectrum of Side Effects and Drug InteractionsVerapamil hepatotoxicity: A hypersensitivity reactionTiapamil, a new calcium channel blocking agent for the treatment of effort induced chronic stable angina pectorisThe efficacy and safety of high-dose verapamil and diltiazem in the long-term treatment of stable exertional anginaRandomized double-blind comparison of gallopamil and propranolol in stable angina pectorisLiver damage from verapamil.Cardiac arrest after reversal of effects of opiates with naloxone.Letter to the EditorProfound hyperglycemia and metabolic acidosis after verapamil overdoseClinical applications of slow channel blocking compoundsCalcium antagonists: A new class of drugsHuman liver plasma membrane Ca-ATPase: Identification and sensitivity to calcium antagonistsLong-term effectiveness of verapamil in stable and unstable angina pectorisTreatment of stable angina of effort with verapamil: a double-blind, placebo-controlled randomized crossover study.Anti-anginal and beta-adrenoceptor blocking drugs 1 April 1981Volume 94, Issue 4_Part_1Page: 490-491KeywordsAnginaArrhythmiaCalcium channelsCatheterizationConstipationExerciseHypotensionNauseaStenosis ePublished: 1 December 2008 Issue Published: 1 April 1981 PDF downloadLoading ...