tbuckley/cabot-search huggingface dataset:
Emergence of BCR-ABL–specific cytotoxic T cells in the bone marrow of patients with Ph+ acute lymphoblastic leukemia during long-term imatinib mesylate treatment
Authors: Giovanni Riva, Mario Luppi, Patrizia Barozzi, Chiara Quadrelli, Sabrina Basso, Daniela Vallerini, Eleonora Zanetti, Monica Morselli, Fabio Forghieri, Monica Maccaferri, Francesco Volzone, Cinzia Del Giovane, Roberto D'Amico, Franco Locatelli, Giuseppe Torelli, Patrizia Comoli, Leonardo Potenza
Journal: Blood (2009)
The Soviet Health System — Aspects of Relevance for Medicine in the United States
Authors: James E. Muller, Faye G. Abdellah, F. T. Billings, Arthur E. Hess, Donald Petit, Roger O. Egeberg
Journal: New England Journal of Medicine (1972)

Abstract A survey of the delivery of health care in the Soviet Union was carried out during a period of three weeks. Health services in the USSR are governmentally controlled, activities are planned and centrally directed, prevention is stressed, and no fees are charged. Medical education consists of six years of training past secondary school and at least a one-year internship. Continuing education is encouraged and can increase a physician's low pay. Hospital midwives are numerous, but there is a shortage of nurses; rural feldshers will be retained only in isolated areas. The basic unit of health service is the uchastok (district), containing about 4000 adults. In cities, health care is readily accessible from polyclinics; care is less accessible in rural areas. Specialized emergency care is available within 10 minutes in large cities. Elaborate health statistics are compiled for planning.
STUDIES IN METHIONINE METABOLISM. II. FASTING PLASMA METHIONINE LEVELS IN NORMAL AND HEPATOPATHIC INDIVIDUALS IN RESPONSE TO DAILY METHIONINE INGESTION 1
Authors: Laurance W. Kinsell, Harold A. Harper, Grace K. Giese, Sheldon Margen, David P. McCallie, Jean R. Hess
Journal: Journal of Clinical Investigation (1949)

1. On Sunday of Week No. 2, 3 gms. of DL-methionine were administered at 1:00 p.m. and 8:00 p.m.2. Thereafter, 3 gms. of methionine were administered at 9:00 a.m., 1:00 p.m. and 8:00 p.m., daily during Weeks No. 2 and No. 3, up to and including 9:00 a.m. on Mon- day of Week No. 4.3. Daily fasting bloods were obtained Monday through Friday for D-and L-methionine during Weeks No. 2 and No. 3. 4. Three-day quantitative urine specimens were ob- tained for methionine assay throughout this period.
Chemosensitivity and Perception of Dyspnea in Patients with a History of Near-Fatal Asthma
Authors: Yoshihiro Kikuchi, Shinichi Okabe, Gen Tamura, Wataru Hida, Masaaki Homma, Kunio Shirato, Tamotsu Takishima
Journal: New England Journal of Medicine (1994)

Many deaths from attacks of asthma may be preventable. However, the difficulty in preventing fatal attacks is that not all the pathophysiologic risk factors have been identified.
ACCELEROMETER-MEASURED PHYSICAL ACTIVITY RECOVERY IN THE FIRST MONTH AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Philip Green, Abigail Woglom, Mathew Maurer, Susan Schnell, Philippe Genereux, Marian Hawkey, Mathew Williams, Ajay Kirtane, Craig Smith, Jeffrey Moses, Martin Leon, Susheel Kodali
Journal: Journal of the American College of Cardiology (2012)
Dedifferentiated fat cells: an alternative source of adult multipotent cells from the adipose tissues
Authors: Jie‐fei Shen, Atsunori Sugawara, Joe Yamashita, Hideo Ogura, Soh Sato
Journal: International Journal of Oral Science (2011)

When adipose‐derived stem cells (ASCs) are retrieved from the stromal vascular portion of adipose tissue, a large amount of mature adipocytes are often discarded. However, by modified ceiling culture technique based on their buoyancy, mature adipocytes can be easily isolated from the adipose cell suspension and dedifferentiated into lipid‐free fibroblast‐like cells, named dedifferentiated fat (DFAT) cells. DFAT cells re‐establish active proliferation ability and undertake multipotent capacities. Compared with ASCs and other adult stem cells, DFAT cells showed unique advantages in their abundance, isolation and homogeneity. In this concise review, the establishment and culture methods of DFAT cells are introduced and the current profiles of their cellular nature are summarized. Under proper induction culture in vitro or environment in vivo, DFAT cells could demonstrate adipogenic, osteogenic, chondrogenic and myogenic potentials. In angiogenic conditions, DFAT cells could exhibit perivascular characteristics and elicit neovascularization. Our preliminary findings also suggested the pericyte phenotype underlying such cell lineage, which supported a novel interpretation about the common origin of mesenchymal stem cells and tissue‐specific stem cells within blood vessel walls. Current research on DFAT cells indicated that this alternative source of adult multipotent cells has great potential in tissue engineering and regenerative medicine.
Hull General Infirmary
Authors: C. J. Evans
Journal: BMJ (1862)

poison be there, we can't get it out; it is probably there for life; but we can so tone and fortify the system that it feels it not.So I believe we should act in pem- phigus; and the force of the comparison is rather en- hanced when we remember what good service the very same remedies, arsenic and bark, effect in both diseases.Of course il va sans dire, that, if there be manifest derangernent of the liver, stomach, or any other organ, in pemphigus, we must correct it just as we would in ague.Arsenic is no specific for this or any other dis- ease; but, judiciously used, it is an admirable toner of vaso-motor nerves, especially the cutaneous; and this, it seems to me, is just the thing that is needed.Hebra has recently recorded a highly interesting case, the subject of a frightful and inveterate pemphigus, which was treated by continuous immersion in warm water for one hundred days.The pulse and re- spiration became less frequent, the temperature in- creased, and the appetite improved; the secretions were normal, except the urine, which seemed somewuat diminished; and the weight gained was fourteen pounds.(London Medical Review, Jan. 1862.)There can be no idea of elimination here; the benefit was doubtless owing to the exclusion of the air, and the soothing in- tluence of moist warmth upon the diseased surface.[To be continued.]HULL GENERAL INFIRMARY.REPORTS OF CASES.
Quality management in the NHS.
Authors: S. Dowling
Journal: BMJ (1992)

by the authors are prerequisites for any major collaborative audit, and the enthusiasm with which general practitioners in Manchester have accepted the task of improving their standards in the care of diabetes, in collaboration with consultant colleagues, suggests great achievements ahead.We have similar schemes for antenatal care, hypertension, and radiology as well as for facilitating audit in individual practices.Of course, as the authors identified, this work raises educational needs, and we are addressing these.My argument with Berwick and colleagues is that, in the longer term, quality and outcomes as assessed by patients will be seen as clear objectives and that formal audit, though the main tool, may not be all that medical audit advisory groups find themselves asked to do.Already practices are asking for help with organisation and management as well as audit.Perhaps by the end of the decade we shall be restyling ourselves medical quality management groups.
Purpuric Eruption on the Feet of a Healthy Young Woman—Quiz Case
Authors: Aditi Sagdeo, Rachel H. Gormley, Karolyn A. Wanat, Xiaowei Xu, Misha Rosenbach, Junko Takeshita
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Dissociation between cellular K+ loss, reduction in repolarization time, and tissue ATP levels during myocardial hypoxia and ischemia.
Authors: G X Yan, K A Yamada, A G Kléber, J McHowat, P B Corr
Journal: Circulation Research (1993)

The mechanisms underlying the marked increase in [K+]o in response to ischemia are not fully understood. Accordingly, the present study was performed to assess the contribution of ATP-regulated K+ channels by using simultaneous measurements of cellular K+ efflux, [K+]o, transmembrane action potentials, and tissue ATP, ADP, phosphocreatine, and creatine content in a unique isolated, blood-perfused papillary muscle preparation during hypoxia compared with ischemia. During 15 minutes of hypoxic perfusion (PO2, 6.1 +/- 0.9 mm Hg) with normal [K+]o of 4.1 +/- 0.1 mM, action potential duration (APD) was not altered even though tissue ATP levels decreased markedly from 33.5 +/- 1.8 to 14.7 +/- 2.0 nmol.mg protein-1 (p < 0.01). Net cellular K+ efflux, based on measured differences of [K+] between the venous effluent and the perfusate, was 13.23 +/- 0.79 mumol.g wet wt-1 during hypoxia. In contrast, after 15 minutes of zero-flow ischemia, APD at 80% of repolarization (APD80) decreased by 47% from 171 +/- 5 to 92 +/- 5 msec (p < 0.01), but integrated net cellular K+ efflux over 15 minutes of ischemia was 8.4-fold less (1.57 +/- 0.13 mumol.g wet wt-1) than during hypoxia. Tissue ATP levels, however, decreased by only 35.2% to 21.7 +/- 2.1 nmol.mg protein-1, which was significantly less than that induced by 15 minutes of hypoxia. Perfusion with hypoxic blood containing high [K+]o of 10.3 +/- 0.3 mM resulted in APD shortening similar to that observed during ischemia. Cellular K+ loss, however, was inhibited markedly by high [K+]o perfusion (only 4.51 +/- 0.28 mumol.g wet wt-1). Pretreatment with glibenclamide (5 microM), a drug that has been reported to inhibit ATP-regulated K+ channels and accelerate glycolysis in normoxic tissue, partially inhibited cellular K+ efflux during hypoxic perfusion with normal [K+]o (7.35 +/- 0.71 versus 13.23 +/- 0.79 mumol.g wet wt-1, p < 0.01) but had no significant influence on repolarization time or tissue ATP levels. Although glibenclamide partially prevented action potential shortening induced by hypoxic perfusion in the presence of elevated [K+]o, the proportion of cellular K+ efflux reduced by glibenclamide was less (23%) than that observed with glibenclamide in hypoxic perfusion with normal [K+]o (44%).(ABSTRACT TRUNCATED AT 400 WORDS)
Medicine in Cambodian Refugee Camps
Authors: RUDI CONINX
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 April 1987Medicine in Cambodian Refugee CampsRUDI CONINXRUDI CONINXSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-4-642_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article on Cambodian refugee camps (1) contains inaccurate statements which I believe are the result of the short-term exposure of the authors to the complex situation in encampments near the Thai-Kampuchean border. Their short stay did not allow the authors to become familiar with the intricate food distribution system that uses the number of females as its base to distribute food to families. Every female over 110 cm (approximately 8 to 10 years of age) is entitled to 2.5 basic rations. Worker payment rations are given to all workers, not only to males. Supplementary feeding through...Reference1. SOFFERWILDE AH. Medicine in Cambodian refugee camps. Ann Intern Med. 1987;105:618-21. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: United Nations Border Relief Operation Bangkok Thailand PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1987Volume 106, Issue 4Page: 642-643KeywordsCyclic adenosine monophosphateFood Issue Published: 1 April 1987 PDF DownloadLoading ...
Serologic and Virus-Isolation Studies of Patients with Varicella or Herpes-Zoster Infection
Authors: Eli Gold
Journal: New England Journal of Medicine (1966)

VARICELLA and herpes zoster are diseases with very different clinical manifestations and age distribution. However, the causative agents of the two syndromes have been shown to be indistinguishable morphologically, antigenically and biologically.1 2 3 The basis for the great difference in response to the same virus has not been established although there has been much speculation. The prevalent hypothesis4 is that varicella is the usual response to primary infection whereas herpes zoster is the manifestation of a recrudescent infection in a person with residual antibody persisting from previous varicella. This concept is supported by the observation that varicella occurs principally in children . . .
Users' guides to the medical literature. IX. A method for grading health care recommendations. Evidence-Based Medicine Working Group
Authors: G. H. Guyatt
Journal: JAMA (1995)

THE ULTIMATE PURPOSE of applied health research is to improve health care. Summarizing the literature to adduce recommendations for clinical practice is an important part of the process. Recently, the health sciences community has reduced the bias and imprecision of traditional literature summaries and their associated recommendations through the development of rigorous criteria for both literature overviews<sup>1-3</sup>and practice guidelines.<sup>4,5</sup>Even when recommendations come from such rigorous approaches, however, it is important to differentiate between those based on weak vs strong evidence. Recommendations based on inadequate evidence often require reversal when sufficient data become available,<sup>6</sup>while timely implementation of recommendations based on strong evidence can save lives.<sup>6</sup>In this article, we suggest an approach to classifying strength of recommendations. We direct our discussion primarily at clinicians who make treatment recommendations that they hope their colleagues will follow. However, we believe that any clinician who attends to
Montelukast versus salmeterol in patients with asthma and exercise-induced bronchoconstriction
Authors: Cesar Villaran, Shane J. O’Neill, Arthur Helbling, Jan A. van Noord, Tak H. Lee, Alexander G. Chuchalin, Stephen J. Langley, Kulasiri A. Gunawardena, Stanislav Suskovic, Martino Laurenzi, Jay Jasan, Joris Menten, Jonathan A. Leff
Journal: Journal of Allergy and Clinical Immunology (1999)
Roche and Novartis colluded over wet AMD drugs, says Italian regulator
Authors: D. Cohen
Journal: BMJ (2014)

The Swiss drug companies Roche and Novartis have been fined €180m (£150m; $250m) by Italy’s competition authority for allegedly colluding to prevent the use of the cheaper of two drugs in the treatment of wet age related macular degeneration.

The Italian regulator accused the two companies of striking an alliance to prevent the use of Roche’s bevacizumab (which it markets as Avastin) as a treatment for wet age related macular degeneration in favour of the more expensive ranibizumab (Lucentis), made by Novartis.

Both drugs were developed by Genentech, which Roche acquired in 2009, but only Novartis holds the licence to sell ranibizumab outside the United States. Bevacizumab is approved only as a cancer treatment, though both drugs act by inhibiting vascular endothelial growth factor, preventing blood vessel growth. 

The report by the Italian Competition Authority …
A REVERSIBLE BED FRAME FOR SPINAL AND OTHER SPECIAL CASES
Authors: E. W. H. Groves
Journal: BMJ (1930)

TMBICALrI-]H 1 of Bi. t/Ypho.sos.Of these, two p)reselted the clifli( al lietule of cholecystitis-one havinig gall-,stonies.The gallbladdert wvall of tile thiird case was the only part of the body foutnid to be inifected withi the eniteric ol'gaiiisIII.T'he fourth sinulated acute appendiciti.All foil casexs presnited profound toxic manifestations, aii irregular telil- peiatlre and abdominmal paini.Examiniation of the abdoileni revealed ait most only sli'olIt riu'iditv, iio rash antd nio recognizable enlargeenint of the spleen.2. A lplea is made for thlorough actertiological examina- tioII of cases w-itlh vague abdominal sym miptomiis wiv'ic (t(o iot colrrespai(l chtsI ly to nov mild digestive distut h utee o t-ute ai hdomimifil (co]n(litioni.3. Iii thie interests of the coinniun4tv cntc ic} <',iuicrs ,sliould he " tracked andyi),' .ittw, n uc 's-ai axIliiii s- trative action shouldl be takeni to mui1innii z theim dao er to t'hose around tlheni, esp)eciall by b prohil)itic tolei emlpl)loymitelit in any hbusiless where, foo(d is handled.In conelusion, I desire to thianik Professor T. J. Ma-kie for guildaice ii t lic
OUTCOMES OF PATIENTS WITH ACUTE CORONARY SYNDROMES AND PRIOR CORONARY ARTERY BYPASS GRAFTING: ANALYSIS FROM THE ACUITY TRIAL
Authors: Eugenia Nikolsky, Roxana Mehran, E. Magnus Ohman, Michel E. Bertrand, A. Michael Lincoff, Jeffrey W. Moses, Ecaterina Cristea, Harvey D. White, Martin Fahy, Alexandra J. Lansky, Gregg W. Stone
Journal: Journal of the American College of Cardiology (2010)
A zebrafish model of intrahepatic cholangiocarcinoma by dual expression of hepatitis B virus X and hepatitis C virus core protein in liver
Authors: Wangta Liu, Jim-Ray Chen, Chih-Hao Hsu, Yen-Hsing Li, Yi-Meng Chen, Chien-Yuan Lin, Shin-Jie Huang, Zen-Kuei Chang, Yen-Chun Chen, Chi-Hsueh Lin, Hong-Yi Gong, Ching-Chun Lin, Koichi Kawakami, Jen-Leih Wu
Journal: Hepatology (2012)

The mechanisms that mediate the initiation and development of intrahepatic cholangiocarcinoma (ICC) associated with hepatitis B and C virus (HBV and HCV, respectively) infection remain largely unclear. In this study we conditionally coexpressed hepatitis B virus X (HBx) and hepatitis C virus core (HCP) proteins in zebrafish livers, which caused fibrosis and consequently contributed to ICC formation at the age of 3 months. Suppressing the transgene expression by doxycycline (Dox) treatment resulted in the loss of ICC formation. The biomarker networks of zebrafish ICC identified by transcriptome sequencing and analysis were also frequently involved in the development of human neoplasms. The profiles of potential biomarker genes of zebrafish ICC were similar to those of human cholangiocarcinoma. Our data also showed that the pSmad3L oncogenic pathway was activated in HBx and HCP-induced ICC and included phosphorylation of p38 mitogen-activated proteinbase (MAPK) and p44/42 mitogen-activated protein kinase (ERK1/2), indicating the association with transforming growth factor beta 1 (TGF-β1) signaling pathway in ICC. Bile duct proliferation, fibrosis, and ICC were markedly reduced by knockdown of TGF-β1 by in vivo morpholinos injections. Conclusion: These results reveal that TGF-β1 plays an important role in HBx- and HCP-induced ICC development. This in vivo model is a potential approach to study the molecular events of fibrosis and ICC occurring in HBV and HCV infection. (HEPATOLOGY 2012;56:2268–2276)
Abstract 4545: Positron emission tomography (PET) of TSPO expression in preclinical models of human cancer
Authors: Dewei Tang, Matthew R. Hight, Eliot T. Mckinley, Allie Fu, Jason R. Buck, Adam Smith, Mohammed Noor Tantawy, Daniel Colvin, Mohammad S. Ansari, Mike Nickels, Henry C. Manning
Journal: Cancer Research (2012)

Abstract There is a critical need to develop and rigorously validate molecular imaging biomarkers to aid diagnosis and characterization of human cancer. Elevated expression of translocator protein (TSPO) has been shown to predict disease progression and aggressive, invasive behavior in a variety of solid tumors. Thus, noninvasive molecular imaging of TSPO expression could form the basis of a novel, predictive cancer imaging biomarker. In quantitative preclinical PET studies, we have evaluated a high-affinity pyrazolopyrimidinyl TSPO imaging ligand ([18F]DPA-714) and an aryloxyanilide-based TSPO imaging ligand ([18F]PBR06), as translational probes for quantification of TSPO levels in glioma, breast cancer, and colorectal cancer. In these studies, glioma-bearing rats or genetically engineered mice bearing spontaneously arrising breast or colorectal cancers were imaged with TSPO PET ligands in a microPET system. Dynamic images were acquired simultaneously upon injection of radioactive TSPO PET ligands. Arterial blood was collected to derive the input function (AIF), with HPLC radiometabolite analysis performed upon select samples for AIF correction. Compartmental modeling was performed using the corrected AIF. Immediately following imaging, tumor and healthy surrounding tissues were harvested for validation by western blotting and immunohistochemistry. Our results illustrate the feasibility of using TSPO PET ligands for visualization of TSPO-expressing tumors of the brain, breast and colon. Importantly, both [18F]DPA-714 and [18F]PBR06 appear suitable for quantitative assay of tumor TSPO levels in vivo. Given the relationship between elevated TSPO levels and poor outcome in oncology, these studies suggest the potential of these imaging agents to serve as a novel predictive cancer imaging biomarkers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4545. doi:1538-7445.AM2012-4545
The Future of Stroke Treatment
Authors: John W. Krakauer, Argye E. Hillis
Journal: JAMA Neurology (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal