tbuckley/cabot-search huggingface dataset:
Comment on Hinnouho et al. Metabolically Healthy Obesity and Risk of Mortality: Does the Definition of Metabolic Health Matter? Diabetes Care 2013;36:2294–2300
Authors: Wolfram Doehner, Andreas F.H. Pfeiffer
Journal: Diabetes Care (2014)

Hinnouho et al. (1) demonstrate in their recent article that the category of metabolically healthy obese subjects does not carry a prognostic benefit over metabolically abnormal obese subjects. This holds true across a variety of methods used to define so-called metabolically healthy obesity. In other words, those more complex criterion clusters and indices to specify an adverse metabolic balance provide no additional prognostic information that could not be obtained with similar validity from a simple measurement of BMI. This report seems to challenge the clinical relevance of the widely discussed concept of metabolically healthy obesity that has been defined above and beyond the mere condition of overweight and obesity.

These …
A piece of my mind. We'll replace the valve
Authors: B. M. Hess
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Continuity of care in general practice: effect on patient satisfaction.
Authors: P. Hjortdahl, E. Laerum
Journal: BMJ (1992)

To evaluate the influence of continuity of care on patient satisfaction with consultations.Direct and episodic specific evaluation of patient satisfaction with recent consultation.A representative sample of 3918 Norwegian primary care patients were asked to evaluate their consultations by filling in a questionnaire. The response rate was 78%.The patient's overall satisfaction with the consultation was rated on a six point scale. Continuity of care was recorded as the duration and intensity of the present patient-doctor relationship and as patients' perception of the present doctor being their personal doctor or not.The multivariate analysis indicated that an overall personal patient-doctor relationship increased the odds of the patient being satisfied with the consultation sevenfold (95% confidence interval 4.9 to 9.9) as compared with consultations where no such relationships existed. The duration of the patient-doctor relationship had a weak but significant association with patient satisfaction, while the intensity of contacts showed no such association.Personal, continuous care is linked with patient satisfaction. If patient satisfaction is accepted as an integral part of quality health care, reinforcing personal care may be one way of increasing this quality.
Detection of Osseous Lesions in Gorlin??s Syndrome by Technetium-99m MDP
Authors: HAMEED U. PERACHA, THOMAS R. FLYNN, RICHARD P. SPENCER
Journal: Clinical Nuclear Medicine (1988)

A man presented with the criteria for diagnosing Gorlin's syndrome (multiple basal cell carcinomas, jaw cysts, intracranial calcifications). The midline calcifications were metabolically active as shown by significant accumulation of Tc-99m MDP. A bifid rib, often associated with this cluster of findings, was also noted on the bone image.
Albumin is not suitable as a marker of bronchoalveolar lavage dilution in interstitial lung disease
Authors: C Ward, J Fenwick, H Booth, EH Walters
Journal: European Respiratory Journal (1997)

We have investigated the origin of raised bronchoalveolar lavage (BAL) albumin levels in interstitial lung diseases (ILDs), and the hypothesis that acute flux during BAL might contribute to the elevated levels of albumin in samples from ILD patients. Total albumin concentrations were measured in three separately aspirated 60 mL aliquots of BAL in 12 ILD patients and seven control subjects, and previous work indicating that BAL albumin levels may be raised in ILD was confirmed. In addition, the extent of acute flux from the circulation was investigated using 1.48 MBq of 125I-radiolabelled human serum albumin injected intravenously shortly before the procedure. It was found that acute albumin flux occurred in only a minority of the ILD patients (4 out of 12) and control subjects (3 out of 7). These results indicate that the elevated levels of plasma proteins, such as albumin, documented in BAL aspirates from ILD patients are not an artefact of the BAL procedure related to increased vascular permeability, and that this finding is more likely to be related to the effects of chronic inflammatory changes in the lung due to the underlying disease. The work confirms that albumin is unsuitable as a denominator for the normalization of bronchoalveolar lavage solute results, since levels can vary, both as a result of acute flux and, more frequently, because of disease activity.
‘Cold Lesions’ on Bone Scan A Case of Metastatic Squamous Cell Carcinoma of the Penis
Authors: TERESA R. CAHILL, ELIZABETH OATES
Journal: Clinical Nuclear Medicine (1991)

Photopenic osseous lesions are a well-recognized but unusual manifestation of metastatic disease on bone scintigraphy. Common primary tumors giving rise to such lesions include lung, breast, renal, and thyroid. This case report illustrates multiple “cold” osseous metastases from aggressive penile squamous cell carcinoma without radiographic destruction.
Associations Between Routine Coronary Computed Tomographic Angiography and Reduced Unnecessary Hospital Admissions, Length of Stay, Recidivism Rates, and Invasive Coronary Angiography in the Emergency Department Triage of Chest Pain
Authors: Michael Poon, Michael Cortegiano, Alexander J. Abramowicz, Margaret Hines, Adam J. Singer, Mark C. Henry, Peter Viccellio, Jeffrey C. Hellinger, Summer Ferraro, Annie Poon, Gilbert L. Raff, Szilard Voros, Michael E. Farkouh, Pamela Noack
Journal: Journal of the American College of Cardiology (2013)
CLINICAL VALUE OF THE CHEMIC ANALYSIS OF GASTRIC JUICE.
Authors: B. BECKER
Journal: JAMA (1895)

Professor Bourget, at Lausanne, being looked upon as authority on all questions concerning the chemistry of the stomach, was invited by the organizing committee of the French Congress for Medicine at Lyon, to give a full report of the named question. The result of his experience, gathered during a number of years from 354 patients, differs in many respects from the views of many physicians at the present time, and a sketch of his resumés must be of interest to the readers of theJournal. Bourget examines the contents of the stomachs of his patients before breakfast, and after a test meal of 200 cubic centimeters of beef tea, 80 grams of chopped meat and 40 grams of bread. After two and one-half hours of digestion, the stomach is emptied by the stomach tube, without aspiration, simply by the contraction of the muscles of the stomach, which under certain conditions
Levothyroxine Loses Potency With Age
Authors: Sheldon S. Stoffer
Journal: JAMA (1986)

<h3>To the Editor.—</h3> We have reported in the past on variations in the potency of levothyroxine products. We initially reported that a brand name levothyroxine product (Synthroid) had only 78% of expected potency.<sup>1</sup>We later reported that as a result of improved monitoring and possible changes in product manufacture, this product was more potent and had 100% of expected potency.<sup>2</sup>Recently, we encountered difficulties in two patients who previously purchased Synthroid in bottles of 1,000 tablets. <h3>Report of Cases.—</h3> Case1.—A 13-year-old boy with primary hypothyroidism was taking 0.15-mg tablets of Synthroid daily. He was generally compliant but would occasionally forget to take his medication two to three times per month. His mother had bought a bottle of 1,000 tablets of Synthroid in 1983. When tested in March 1985, his serum free thyroxine index (FTI) was 1.5 (normal, 1.4 to 4.0) and the serum thyroid-stimulating hormone (TSH) value
Cocaine-Related Vasculitis Causing Upper-Limb Peripheral Vascular Disease
Authors: Norm R.C. Campbell, Nadia Khan
Journal: Annals of Internal Medicine (2001)

Letters17 July 2001Cocaine-Related Vasculitis Causing Upper-Limb Peripheral Vascular DiseaseNorm R.C. Campbell, MD, FRCPC and Nadia Khan, MDNorm R.C. Campbell, MD, FRCPCUniversity of Calgary; Calgary, Alberta T2N 4N1, Canada (Campbell, Khan)Search for more papers by this author and Nadia Khan, MDUniversity of Calgary; Calgary, Alberta T2N 4N1, Canada (Campbell, Khan)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-2-200107170-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Kumar and Smith (1) describe a case of cocaine-related vasculitis associated with peripheral vascular disease in a 48-year-old man with a history of smoking. In the case report, a blood pressure of 146/92 mm Hg is described as normal. However, this blood pressure reading is consistent with stage I hypertension and needs to be recognized as abnormal (2) and further evaluated. If this elevated pressure persisted, then appropriate management would be required, especially since smoking and cocaine use are risk factors for atherosclerotic disease (2, 3).References1. Kumar PD, Smith HR. Cocaine-related vasculitis causing upper-limb peripheral vascular disease [Letter]. Ann Intern Med. 2000;133:923-4. [PMID: 11103072] LinkGoogle Scholar2. . The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Arch Intern Med. 1997;157:2413-46. [PMID: 9385294] CrossrefMedlineGoogle Scholar3. Dressler FA, Malekzadeh S, Roberts WC. Quantitative analysis of amounts of coronary arterial narrowing in cocaine addicts. Am J Cardiol. 1990;65:303-8. [PMID: 2301258] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Norm R.C. Campbell, MD, FRCPC; Nadia Khan, MDAffiliations: University of Calgary; Calgary, Alberta T2N 4N1, Canada (Campbell, Khan) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCocaine-Related Vasculitis Causing Upper-Limb Peripheral Vascular Disease P. Dileep Kumar and Howard R. Smith Metrics 17 July 2001Volume 135, Issue 2Page: 142KeywordsBlood pressureCocaineHypertensionMedical risk factorsPeripheral vascular diseaseVasculitis ePublished: 17 July 2001 Issue Published: 17 July 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
An Introduction to Clinical Pathlology
Authors: R. W. E. Watts
Journal: BMJ (1965)

MD:IcBtioURNAL non-specifically toxic.If tanned red cells were treated with extract of kidney antigen from the donor then they were agglutinated specifically by lymphocytes.This pheno- menon was heat-labile and was not enhanced by recipient serum.This volume is a highly specialized mono- graph written in French, and contains some important contributions to an understanding of transplantation phenomena.It will be of value to all those interested in tissue trans- plantation.R. Y. CALNE.
Unilateral Absence of the Vas Deferens
Authors: Robert E. Donohue
Journal: JAMA (1989)

The vas deferens is infrequently palpated at the time of routine physical examination or even during examination of the scrotum. Its absence, especially unilaterally, has been associated both clinically and at the time of autopsy with ipsilateral renal anomalies, especially agenesis. Twenty-six patients with unilateral agenesis of the vas deferens were examined for the presence of an ipsilateral renal unit; 25 patients were examined by intravenous pyelography and one by bone scan. Twenty-two patients were missing the ipsilateral renal unit. Contralateral abnormalities occurred in seven (33%) of these 22 patients also. The absence of the vas deferens is a significant anomaly, and examination for the presence of the ipsilateral renal unit is mandatory.
Genome-wide DNA Methylation Events in <i>TMPRSS2–ERG</i> Fusion-Negative Prostate Cancers Implicate an EZH2-Dependent Mechanism with <i>miR-26a</i> Hypermethylation
Authors: Stefan T. Börno, Axel Fischer, Martin Kerick, Maria Fälth, Mark Laible, Jan C. Brase, Ruprecht Kuner, Andreas Dahl, Christina Grimm, Behnam Sayanjali, Melanie Isau, Christina Röhr, Andrea Wunderlich, Bernd Timmermann, Rainer Claus, Christoph Plass, Markus Graefen, Ronald Simon, Francesca Demichelis, Mark A. Rubin, Guido Sauter, Thorsten Schlomm, Holger Sültmann, Hans Lehrach, Michal R. Schweiger
Journal: Cancer Discovery (2012)

Prostate cancer is the second most common cancer among men worldwide. Alterations in the DNA methylation pattern can be one of the leading causes for prostate cancer formation. This study is the first high-throughput sequencing study investigating genome-wide DNA methylation patterns in a large cohort of 51 tumor and 53 benign prostate samples using methylated DNA immunoprecipitation sequencing. Comparative analyses identified more than 147,000 cancer-associated epigenetic alterations. In addition, global methylation patterns show significant differences based on the TMPRSS2-ERG rearrangement status. We propose the hypermethylation of miR-26a as an alternative pathway of ERG rearrangement-independent EZH2 activation. The observed increase in differential methylation events in fusion-negative tumors can explain the tumorigenic process in the absence of genomic rearrangements.In contrast to TMPRSS2-ERG -rearranged tumors, the pathomechanism for gene fusion-negative tumors is completely unclear. Using a sequencing-based approach, our work uncovers significant global epigenetic alterations in TMPRSS2-ERG gene fusion-negative tumors and provides a mechanistic explanation for the tumor formation process.
Abstract B57: Overcoming Acquired Resistance in Philadelphia-Positive (Ph+) Leukemia
Authors: Mamduh Khateb, Yousef Najajrah, Martin Ruthardt, Jamal Mahajna
Journal: Clinical Cancer Research (2012)

Abstract Chronic myeloid leukemia (CML) is characterized by the presence of p210Bcr-Abl which exhibits an abnormal kinase activity. Selective Abl kinase inhibitors (AKIs) have been successfully established for the treatment of CML. Despite high rates of clinical response, CML patients can develop resistance. Acquired resistance to AKIs in Ph+ leukemia is mostly due to the acquisition of point mutations within the Bcr-Abl Kinase by either reducing the affinity of the kinase domain to the ATP-competitor or stabilizing the active confirmation of the Abl kinase domain. Thus, acquired drug resistance in Philadelphia positive (Ph+) leukemia and in particular the gatekeeper mutation, T315I, to Abl kinase inhibitors (AKIs), represents a major obstacle in overcoming Bcr-Abl positive leukemia. T315I mutation is refractory to clinically available AKIs, as well as to Abl allosteric inhibitors such as GNF-2. In this study, we documented cooperation between AKIs and GNF-2 in inhibiting proliferation and clonigenicity of Ba/F3 cells carrying T315I mutated Bcr-Abl. Interestingly, cooperation was most evident between dasatinib and GNF-2. Cooperation was also documented in the ALL SupB15 cell line. Cooperation in cells carrying native Bcr-Abl gene was mediated by Bcr-Abl. In contrast, proliferation and clonigenicity inhibition of Ph+ cells harboring the T315I mutation was not mediated by Bcr-Abl, but apparently by Bcr-Abl-independent mechanisms. Moreover, previously we have identified oleic acid as the active component in the mushroom Daedalea gibbosa who inhibited the kinase activity of Bcr-Abl apparently by allosteric inhibition. Here, we report that derivatives of oleic acid, oleylamine-carbonyl L-valinol and oleylamine-carbonyl D-valinol, inhibited the activity of the native and T315I mutated Bcr-Abl. Furthermore, oleylamine-carbonyl L-valinol and oleylamine-carbonyl D-valinol, exhibited higher activity toward the oncogenic Bcr-Abl in comparison to native c-Abl in SupB15, Ph-positive ALL cell line.
Benign Stenoses - Benign Tumors
Authors: G.N.J. Tytgat
Journal: Endoscopy (1986)

Some reflections and critical comments are given with respect to the application of Nd:YAG laser photocoagulation in benign conditions such as benign (anastomotic) strictures and especially benign polypoid adenomatous lesions of the gastrointestinal tract. Many questions still need to be answered before the full impact of laser in benign lesions is appreciated. A most distressing fact at present is the high local recurrence rate of adenomatous or carcinomatous tissue after apparently complete eradication of usually sessile adenomatous/carcinomatous lesions.
Racial Characters of Skin in Relation to Health
Authors: H. J. Fleure
Journal: BMJ (1926)

PROFESSOR FLEURE said it seemed appropriate to devote the first Malcolm Morris Memolial Lecture to a consideration of the racial characters of the human skin and racial types in.relationi to health, because Malcolma Morris had been concerned in practice with the treatmlient of disorders of the skin, and also actively interested in hygiene-in the art of right livinig anid the right use of environment, sunshine, fresh air, and cleaniliness.
The use of echocardiography in diagnosing culture-negative endocarditis.
Authors: D S Rubenson, C R Tucker, E B Stinson, E J London, P Oyer, R Moreno-Cabral, R L Popp
Journal: Circulation (1981)

We reviewed M-mode and two-dimensional echocardiographic findings in 11 patients with abacteremic endocarditis to study the application of echocardiography in this setting. All patients had negative blood cultures but underwent surgery that confirmed the presence of active infective endocarditis. The infection involved native valves in five patients and prosthetic valves in six patients. Valvular masses were identified in eight patients. The other three patients, who had prosthetic aortic valves, had diastolic mitral valve vibration characteristic of aortic regurgitation. One of these also showed dehiscence of the prosthesis. Three patients had poorly defined clinical illnesses and echocardiography was a prime element in the diagnosis because valvular masses were identified. The operation was facilitated by knowledge of the mass indicated by echocardiography in these eight cases. Also, the surgical approach was affected by knowledge of dehiscence and perivalvular abscess formation in two cases each.
Helminth infections: the great neglected tropical diseases
Authors: Peter J. Hotez, Paul J. Brindley, Jeffrey M. Bethony, Charles H. King, Edward J. Pearce, Julie Jacobson
Journal: Journal of Clinical Investigation (2008)

Helminths are parasitic worms. They are the most common infectious agents of humans in developing countries and produce a global burden of disease that exceeds better-known conditions, including malaria and tuberculosis. As we discuss here, new insights into fundamental helminth biology are accumulating through newly completed genome projects and the nascent application of transgenesis and RNA interference technologies. At the same time, our understanding of the dynamics of the transmission of helminths and the mechanisms of the Th2-type immune responses that are induced by infection with these parasitic worms has increased markedly. Ultimately, these advances in molecular and medical helminth biology should one day translate into a new and robust pipeline of drugs, diagnostics, and vaccines for targeting parasitic worms that infect humans.
Reduction of soluble ICAM‐1 levels in nasal secretion by H<sub>1</sub>‐blockers in seasonal allergic rhinitis
Authors: A. Campbell, I. Chanal, W. Czarlewski, F.‐B. Michel, J. Bousquet
Journal: Allergy (1997)

ICAM‐1, a transmembrane glycoprotein promoting adhesion in immunologic and inflammatory reactions, was found to be increased on nasal epithelial cells of patients with allergic rhinitis. Loratadinae, an H 1 ‐Mocker, was found to reduce in vitro the expression of ICAM‐1 on nasal epithelial cells. A double‐blind, parallel‐group study was carried out during the pollen season to compare the effect of two H 1 ‐blockers, cetiraizine (10 mg OD) and loratadine (10 mg OD), on the release of soluble ICAM‐1 in nasal secretions. A group of untreated patients was used as a control group. sICAM‐1 was measured by enzyme immunoassay before and after 2 weeks of treatment. Symptoms were significantly decreased in the actively treated groups. sICAM‐1 levels were unchanged in the control group but were significantly reduced in the two treated groups ( P &lt;0.015, Wilcoxon's W test). This study shows that two H 1 ‐blockers, loratadine and cetirizinae, have a similar effect on sICAM‐1 released in nasal secretions during the pollen season.
[217] MIDODRINE VERSUS ALBUMIN IN THE PREVENTION OF PARACENTESIS INDUCED CIRCULATORY DYSFUNCTION IN PATIENTS WITH CIRRHOSIS AND TENSE ASCITES? A RANDOMIZED STUDY
Authors: B. Appenrodt, A. Wolf, F. Gruenhage, J. Trebicka, M. Schepke, T. Sauerbruch, J. Heller
Journal: Journal of Hepatology (2007)