Lactic Acidosis: The Case Against Bicarbonate Therapy
Authors: PETER W. STACPOOLE
Journal: Annals of Internal Medicine (1986)

Editorials1 August 1986Lactic Acidosis: The Case Against Bicarbonate TherapyPETER W. STACPOOLE, Ph.D, M.D.PETER W. STACPOOLE, Ph.D, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-2-276 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLactic acidosis is perhaps the commonest and most poorly treated acid-base disorder. If a blood lactate concentration of at least 5 meq/L (5 mmol/L) and an arterial pH of 7.2 or less are the criteria, the reported incidence of lactic acidosis among adult hospitalized patients not having surgery is about 1% (1). Approximately 60% to 70% of all patients with lactic acidosis die (1, 2) and, among those in whom hypotension coexists, mortality approaches 100% (3-6).Based on these statistics alone, the conclusion is inescapable that present therapy for lactic acidosis is inadequate. 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HOLLANDER, M.D.Bicarbonate Therapy for Organic Acidosis: The Case for Its Continued UseROBERT G. NARINS, M.D., JORDAN J. COHEN, M.D.Lactic Acidosis: An UpdateImprovements of metabolic imbalances after enteral sodium bicarbonate supplementation in infants of very low birth weight (VLBW) (Short communication)Emergencies in Acute Lymphoblastic Leukemia 1 August 1986Volume 105, Issue 2Page: 276-279KeywordsAttentionBicarbonatesBloodHypotensionLactatesLactic acidosisMortalitySurgery Issue Published: 1 August 1986 PDF downloadLoading ...