tbuckley/cabot-search huggingface dataset:
Contraceptive Action of Continuous Low Doses of Norgestrel
Authors: G. L. Foss, E. K. Svendsen, K. Fotherby, D. J. Richards
Journal: BMJ (1968)

Norgestrel in a dose of 50 mug. was administered daily to 188 women during 2,250 menstrual cycles. Only two pregnancies occurred because of failure of the method, giving a failure rate of 1.1 pregnancies per 100 woman-years. The method was acceptable to most of the subjects, and side-effects, other than menstrual irregularity, were minimal; 68% of the cycles were 28 +/-5 days in length and 21% were less than 23 days. There did not appear to be any increased incidence of amenorrhoea. The antifertility action of continuous administration of low doses of progestogen may be due to an effect on corpus luteum function, in addition to the effects on cervical mucus, endometrium, and tubal transport of ova. The optimum dose of norgestrel appears to be in the range of 50-75 mug./day.
Lipschutz's genital ulceration: a manifestation of Epstein-Barr viruas primary infection
Authors: A. Lampert, H. Assier-Bonnet, B. Chevallier, T. Clerici, P. Saiag
Journal: British Journal of Dermatology (1996)

Journal Article Lipschutz's genital ulceration: a manifestation of Epstein–Barr viruas primary infection Get access A. Lampert, A. Lampert Service de Dermatologie 9 avenue du Général de Gaulle, 92104 Boulogne, Billancourt, France Search for other works by this author on: Oxford Academic Google Scholar H. Assier‐Bonnet, H. Assier‐Bonnet Service de Dermatologie 9 avenue du Général de Gaulle, 92104 Boulogne, Billancourt, France Search for other works by this author on: Oxford Academic Google Scholar B. Chevallier, B. Chevallier Pédiatrie Hôpital Ambroise Paré, Université Paris V, 9 avenue du Général de Gaulle, 92104 Boulogne, Billancourt, France Search for other works by this author on: Oxford Academic Google Scholar T. Clerici, T. Clerici Anatomo‐Pathologie, Hôpital Ambroise Paré, Université Paris V, 9 avenue du Général de Gaulle, 92104 Boulogne, Billancourt, France Search for other works by this author on: Oxford Academic Google Scholar P. Saiag P. Saiag Service de Dermatologie 9 avenue du Général de Gaulle, 92104 Boulogne, Billancourt, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 135, Issue 4, 1 October 1996, Pages 663–665, https://doi.org/10.1111/j.1365-2133.1996.tb03866.x Published: 01 October 1996
The Molecular Basis for Genetic Deficiency of the Second Component of Human Complement
Authors: F. Sessions Cole, Alexander S. Whitehead, Harvey S. Auerbach, Thomas Lint, Howard J. Zeitz, Peter Kilbridge, Harvey R. Colten
Journal: New England Journal of Medicine (1985)

Genetic deficiency of the second component of complement (C2) is the most common complement-deficiency state among Western Europeans and is frequently associated with autoimmune diseases. To examine the molecular basis of this deficiency, we established cultures of blood monocytes from four families with C2-deficient members. Using a hemolytic-plaque assay, [35S]methionine metabolic labeling of proteins in tissue culture and immunoprecipitation, RNA extraction and Northern blot analysis, and DNA restriction-enzyme digestion and Southern blot analysis, we found that C2 deficiency is not due to a major gene deletion or rearrangement but is the result of a specific and selective pretranslational regulatory defect in C2 gene expression. This leads to a lack of detectable C2 mRNA and a lack of synthesis of C2 protein. The approach used in this study should prove useful in examination of other plasma protein deficiencies, especially those in which the deficient gene is normally expressed in peripheral-blood monocytes or tissue macrophages and in which ethical considerations preclude the use of liver or other tissue for study. (N Engl J Med 1985; 313:11–6.)
Endoscopical Approach to the “Malignant Change of Benign Gastric Ulcer” from our Follow-up Studies
Authors: K. Kawai, Y. Akasaka, Y. Kohli
Journal: Endoscopy (1973)

From our endoscopical long-term observations, we reported the evaluation of malignant change from benign gastric ulcer. Many problems will have to be solved in the future. It is very difficult to confirm the course of malignant change from the morphological follow-up study. We can only emphasize that the biopsy study at the healing stage and 3 to 6 months later is indispensable for the ulcer control and the evaluation of ulcer-carcinoma.
Female circumcision is curbed in Egypt
Authors: J. Wiens
Journal: BMJ (1996)

In the wake of the death of an 11-year-old girl the Egyptian government has banned any government-affiliated medical staff from performing female circumcision. Egyptian health policy has shifted from trying to control the practice by keeping it under government supervision towards condemnation. In October 1995 the health minister banned female circumcision from being carried out in state hospitals, a direct reversal of a 1994 decree that asked state hospitals to set aside one day a week for performing the procedure. The further restriction follows an incident in July 1996 when an 11-year-old girl bled to death in the rural area of Mansoora after being circumcised by a barber. Female genital mutilation in Egypt changed from an accepted custom to a political hot topic after the news network CNN in September 1994 featured the circumcision of a 9-year-old girl from Cairo. The footage embarrassed Egyptians and fueled an outcry by women's groups and nongovernmental organizations. Statistics compiled in 1994 by Egypt's former ministry of population estimated that between 70% and 90% of Egyptian women were circumcised. But a more recent survey puts the figure even higher, with 97% of women in both rural and urban areas having been circumcised. Circumcisions range from clitoridectomies to almost total removal of the outside genitalia. The practice seems to be rooted in both African tradition and Islamic beliefs, although many Islamic countries do not practice female circumcision. The main motivation seems to be in controlling women's sexual urges, and the belief that circumcision makes a woman more feminine. A university professor of gynecology teaches his medical students that circumcision is healthier for the woman. Most circumcisions in Egypt are performed by barbers or midwives, despite a sporadically enforced law forbidding the operation by anyone but a trained medical staff member. There is a high rate of complications, with some operations leading to infertility. Groups like the Population Council hope that further education and public debate will help to stop the practice.
Transcription factors for ion channels: active or passive players in cardiac remodeling?
Authors: D Dobrev
Journal: Cardiovascular Research (2003)

Chronic cardiac disease is associated with structural, mechanical, and electrical remodeling processes that comprise activation of numerous signal transduction pathways [1]. In hypertrophy and heart failure, for instance, electrical remodeling consists of prolongation of the ventricular action potential duration that may be interpreted as an acquired long-QT syndrome and hence may explain the propensity for ventricular arrhythmias. In myocardial biopsies from these patients, the transient outward current I to is significantly down-regulated and this is associated with a lower expression of mRNA for the corresponding ion channel subunits (in man predominantly Kv4.3, in rat predominantly Kv4.2; Ref. [2]). Despite the clinical relevance of I to reduction, the molecular mechanisms regulating ion channel expression in cardiac diseases are currently unknown.

Traditionally, a certain number and species of ion channels within the membrane are considered responsible for the cell type-specific shape of the action potential; however, ion channel numbers should be viewed as highly dynamic. Channel expression can be regulated at multiple cellular levels, i.e. mRNA transcription, altered rates of protein translation, posttranslational protein modifications, changes in membrane trafficking and insertion, and phosphorylation of channel proteins. Regulation of transcription requires regulatory factors that activate or suppress gene expression. These transcription factors bind to certain DNA sequences within the … 

*Tel.: +49-351-458-6279; fax: +49-351-458-6315. Email address: dobrev{at}rcs.urz.tu-dresden.de
TCT-759 Correlates for Device Malposition during Aortic Valve-in-Valve Implantation: Insights from the Global Valve-in-Valve Registry
Authors: Danny Dvir, Ran Kornowski, Susheel Kodali, Sabine Bleiziffer, David Hildick-Smith, Dominique Himbert, Ulrich Schaefer, Josep Rodes-Cabau, Hendrik Treede, Stephen Brecker, Azeem Latib, Jean-Claude Laborde, John Webb
Journal: Journal of the American College of Cardiology (2013)
Mean Platelet Volume is Associated with Poor Post-Interventional Myocardial Blush Grade in Patients with ST Segment Elevation Myocardial Infarction
Authors: Bahadır Şarlı, Ahmet O Baktır, Hayrettin Sağlam, Hüseyin Arınç, Serkan Kurtul, Mahmut Akpek, Mehmet G Kaya
Journal: Journal of the American College of Cardiology (2013)
Guideline Tightens Transfusion Criteria
Authors: Bridget M. Kuehn
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Contagion and Confinement: Controlling Tuberculosis along the Skid Road
Authors: William W. Stead
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes2 November 1999Contagion and Confinement: Controlling Tuberculosis along the Skid RoadWilliam W. Stead, MDWilliam W. Stead, MDTuberculosis Program, Arkansas Department of Health, Little Rock, Arkansas. (Stead)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-9-199911020-00032 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Lerner BH. 243 pages. Baltimore: Johns Hopkins Univ Pr; 1998. $42.50. ISBN 0801858984. Order phone 800-537-5487.Field of medicine: Public health, pulmonology, and infectious disease.Format: Hardcover book.Audience: Physicians and administrators in public health, as well as medical and public health historians.Purpose: To review the history of treatment of patients who have difficulty adhering to the prolonged therapy for tuberculosis.Content: The eight chapters describe the public health program in Seattle (from its inception in 1909) and the treatment of tuberculosis in poor and homeless people. In the early 20th century, susceptibility to tuberculosis was still viewed as ... Author, Article, and Disclosure InformationAffiliations: Tuberculosis Program, Arkansas Department of Health, Little Rock, Arkansas. (Stead) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 2 November 1999Volume 131, Issue 9Page: 720KeywordsAntibacterial therapyInfectious diseasesPatientsPlaguePrevention, policy, and public healthPulmonary medicineSoftware tools ePublished: 15 August 2000 Issue Published: 2 November 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Relationship of Specific Vaginal Bacteria and Bacterial Vaginosis Treatment Failure in Women Who Have Sex with Women
Authors: Jeanne M. Marrazzo, Katherine K. Thomas, Tina L. Fiedler, Kathleen Ringwood, David N. Fredricks
Journal: Annals of Internal Medicine (2008)

Background: Bacterial vaginosis frequently persists after treatment. The role of newly defined bacterial vaginosis–associated bacteria (BVAB), which have a specificity for this condition of 97% or greater, has not been assessed. Objective: To define risks for bacterial vaginosis persistence, including pretreatment detection of specific vaginal bacteria, among women reporting sex with women. Design: Observational cohort study. Setting: University-based research clinic. Patients: 335 women age 16 to 29 years reporting sex with at least 1 woman in the past year. Participants were recruited through advertisements and provider referral. Intervention: Bacterial vaginosis was treated with intravaginal metronidazole gel (0.75%), 37.5 mg nightly for 5 nights. Measurements: Species-specific 16S recombinant DNA polymerase chain reaction assays targeting 17 bacterial species were applied to vaginal fluid obtained at baseline. Test of cure by clinical criteria and Gram stain analysis and repeated polymerase chain reaction assays of vaginal fluid were performed 1 month after treatment, and interim behaviors were assessed by using computer-assisted self-interview. Results: Of 335 women, 24% of whom also reported sex with men within 3 months before enrollment, 131 (39%) had bacterial vaginosis. In the 120 (92%) women who returned for follow-up, the incidence of persistent bacterial vaginosis was 26% and was statistically significantly higher in women with baseline detection of 3 Clostridiales bacteria, designated as BVAB1 (risk ratio, 2.0 [95% CI, 1.1 to 4.0]), BVAB2 (risk ratio, 8.7 [CI, 2.5 to ∞]), or BVAB3 (risk ratio, 3.1 [CI, 1.7 to 5.8]); Peptoniphilus lacrimalis (risk ratio, 3.5 [CI, 1.6 to 15.5]); and Megasphaera phylotype 2 (risk ratio, 3.4 [CI, 1.4 to 5.5]). Persistence was lower with treatment adherence (risk ratio, 0.4 [0.2 to 0.9]). Detection of these bacteria at the test-of-cure visit was associated with persistence, whereas posttreatment sexual activity was not. Limitations: Findings may not be generalizable to women who have sex only with men, or to women whose bacterial vaginosis is treated with oral antibiotics. The study may be too small and may involve a population that is too highly selected to draw definitive conclusions about associations of persistent infection with posttreatment sexual behaviors. Conclusion: Persistent bacterial vaginosis is associated with several bacteria in the Clostridiales order, Megasphaera phylotype 2, and P. lacrimalis, suggesting that vaginal microbiology at diagnosis may determine risk for antibiotic failure.
Does Nissen Fundoplication Decrease Reflux-Related Problems Including Respiratory Illness in Children With Neurological Impairment?—Reply
Authors: Douglas C. Barnhart, Jay G. Berry, Rajendu Srivastava
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Noninvasive Doppler echocardiographic evaluation of shunt flow dynamics of the ductus arteriosus.
Authors: S Hiraishi, Y Horiguchi, H Misawa, K Oguchi, N Kadoi, N Fujino, K Yashiro
Journal: Circulation (1987)

The pulsed Doppler technique was used to record the flow velocity patterns in the ductus arteriosus and the pulmonary artery in 26 patients with either isolated or complicated patent ductus arteriosus (PDA). In all patients, abnormal Doppler signals indicating left-to-right (L-R) or right-to-left shunt flow or both could be obtained at the site of the ductus arteriosus. These Doppler flow patterns determined within the ductus coincided with the direction of ductal flow seen on the contrast two-dimensional echocardiogram. No Doppler signals of shunt flow were demonstrated in any of 42 control subjects. The peak, mean, and diastolic velocities of the L-R shunt flow within the ductus were measured from the ductal flow velocity profiles. With the Doppler-derived measurements of the mean and diastolic velocities, patients with normal pulmonary arterial pressure and those with evidence of pulmonary hypertension could be correctly identified. In addition, the mean velocity of the diastolic antegrade flow portion obtained from the proximal left pulmonary artery, which was related to ductal L-R shunting, was measured in 16 patients with isolated PDA. This Doppler flow determinant showed a good linear correlation with the L-R shunt ratio determined by Fick's method (r = .88, p less than .01). Our technique permits the noninvasive evaluation of shunt flow dynamics in patients with PDA.
Mentoring and the meaning of soul
Authors: K. Abbasi
Journal: Journal of the Royal Society of Medicine (2008)

A new US president and an international financial crisis demonstrate how quickly the world can change. But they also serve to emphasize the resilience of the industry that we are all involved in. At times of crisis, investing in health is always an attractive option. Population explosions, demographic shifts and sophisticated diagnoses mean that healthcare organizations and pharmaceutical companies continue to prosper. Moreover, when economic fears grip the world of private enterprise, jobs in the public sector acquire a reassuring glow of security.
POINTS OF SIMILARITY BETWEEN US AND HOMŒOPATHIC PHYSICIANS.The Annual Address of the President of the Philadelphia County Medical Society for 1892. Read May 24, 1893.
Authors: JOHN B. ROBERTS
Journal: JAMA (1893)

In the address which I had the honor of delivering from the presidential chair a year ago, I gave it as my opinion that this society should be liberal enough to accept as a member any physician whose education and personal character made him a fit associate for intelligent men. I stated my belief that the test of qualification for membership should not be the college from which the applicant received his diploma; but an education enabling him to understand and appreciate the science of medicine, and an honest purpose to treat his patients by all means and methods which experience, investigation and research show to be serviceable. It seemed to me then, as it does now, that such a physician's political, religious or social belief and affiliations should not disqualify him, nor should his opinion that in "similars" he sometimes finds a remedy of value. Following out this line
Adrenomedullin as a predictor of restenosis and antiintimal proliferative hormone in the patients with coronary intervention
Authors: Hiroshi Ikenouchi, Nanae Kada, Nobuhiko Itoh, Tokutada Satoh, Yoshiyuki Hada, Yasunobu Hirata, Kenji Kangawa
Journal: Journal of the American College of Cardiology (2002)
Monitoring Human Exposure to 2-Hydroxyethylating Carcinogens
Authors: Peter B. Farmer, Rosa Cordero, Herman Autrup
Journal: Environmental Health Perspectives (1996)

It is known that human hemoglobin contains low levels of N-terminal N-(2-hydroxyethyl)valine. Possible sources of this modified amino acid are exposure to ethylene oxide or other 2-hydroxy-ethylating agents. Although such processes are likely to occur endogenously, the exogenous contribution to the adduct formation is unclear. In order to explore the latter, we have analyzed N-(2-hydroxyethyl)valine in the globin of 49 pregnant women and evaluated the effect of smoking status, area of residence, and glutathione S-transferase M1 genotype on adduct levels. Transplacental transfer of hydroxyethylating agents was also studied by the analysis of umbilical cord hemoglobin. The adduct levels in smokers were significantly higher than those in nonsmokers. The adduct levels in umbilical cord blood globin were quantitatively related to those in maternal blood (maternal:fetal ratio 2.7 in smokers and 2.8 in nonsmokers). In the nonsmokers, there was no statistically significant difference in the adduct level between the urban and rural areas, but the level in suburbia tended to be lower than that in the rural area. In the combined smoker and nonsmoker groups, there was no effect of the glutathione S-transferase M1 genotype on levels of N-(2-hydroxyethyl)valine.
“The Camel’s Nose — And Hump, Too!”: The Health Professions Educational Assistance Act of 1976
Authors: David R. Challoner, David R. Perry
Journal: New England Journal of Medicine (1977)

The Congress recently has passed and the President has signed into law the Health Professions Educational Assistance Act of 1976 (PL 94–484, 94th Congress). This act is a complex piece of legislation authorizing federal support for a variety of educational programs in many of the health professions, including medicine. Its most controversial provisions involve the requirements related to the health-professions schools' eligibility for capitation grants. In our opinion those requirements are a unique and precedent-setting departure from what previously has been understood to be an appropriate federal role in support of developing the nation's health-manpower resources. They now represent a . . .
Lung mast cells are a source of secreted phospholipases A2
Authors: Massimo Triggiani, Giorgio Giannattasio, Cecilia Calabrese, Stefania Loffredo, Francescopaolo Granata, Alfonso Fiorello, Mario Santini, Michael H. Gelb, Gianni Marone
Journal: Journal of Allergy and Clinical Immunology (2009)
Caring for the Child With Cancer at the Close of Life
Authors: Amy J. Markowitz
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal