tbuckley/cabot-search huggingface dataset:
Who wrote that article?
Authors: Douglas Kamerow
Journal: BMJ (2008)

<h3>PURPOSE</h3> Although waist circumference can provide important metabolic risk information, logistic issues inhibit its routine use in outpatient practice settings. We assessed whether self-measured waist circumference is sufficiently accurate to replace professionally measured waist circumference for identifying high-risk patients. <h3>METHODS</h3> Medical outpatients and research participants self-measured their waist circumference at the same visit during which a professionally measured waist circumference was obtained. Participants were provided with standardized pictorial instructions on how to measure their waist circumference, and professionals underwent standard training. <h3>RESULTS</h3> Self- and professionally measured waist circumference data were collected for 585 women (mean ± SD age = 40 ± 14 years, mean ± SD body mass index = 27.7 ± 6.0 kg/m<sup>2</sup>) and 165 men (mean ± SD age = 41 ± 14 years, mean ± SD body mass index = 29.3 ± 4.6 kg/m<sup>2</sup>). Although self- and professionally measured waist circumference did not differ significantly, we found a clinically important false-negative rate for the self-measurements. Eleven percent of normal-weight and 52% of overweight women had a professionally measured waist circumference putting them in a high-risk category for metabolic syndrome (ie, greater than 88 cm); however, 57% and 18% of these women, respectively, undermeasured their waist circumference as falling below that cutoff. Fifteen percent and 84% of overweight and class I obese men, respectively, had a professionally measured waist circumference putting them in the high-risk category (ie, greater than 102 cm); however, 23% and 16% of these men, respectively, undermeasured their waist circumference as falling below that cutoff. <h3>CONCLUSIONS</h3> Despite standardized pictorial instructions for self-measured waist circumference, the false-negative rate of self-measurements approached or exceeded 20% for some groups at high risk for poor health outcomes.
Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression
Authors: Keiki Kumano, Shigeru Chiba, Kiyoshi Shimizu, Tetsuya Yamagata, Noriko Hosoya, Toshiki Saito, Tokiharu Takahashi, Yoshio Hamada, Hisamaru Hirai
Journal: Blood (2001)
Immunomodulatory activity of SGI-110: a basis for novel chemo-immunotherapeutic combinations in cancer treatment
Authors: Alessia Covre, Giulia Parisi, Hugues JMG Nicolay, Carolina Fazio, Ester Fonsatti, Elisabetta Fratta, Luca Sigalotti, Pietro Taverna, Gavin Choy, Mohammad Azab, Sandra Coral, Michele Maio
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Aberrant DNA hypermethylation favors tumor escape from host’s immune recognition by decreasing the expression of tumor-associated antigens (TAA) (e.g., cancer testis antigens (CTA)), HLA, co-stimulatory molecules that are all required for efficient immune recognition of cancer
Bright Air, Brilliant Fire: On the Matter of the Mind
Authors: Gerald F. Tremblay
Journal: JAMA (1992)

The brain is like the immune system. Both recognize external influences and respond to them. A type of memory is present in both brain and immune cells. The analogies between the brain and the immune system have been a topic of Gerald Edelman's writings for about 20 years. Apart from his more recent works in neuroscience, the author is probably best known for deciphering the structure of the antibody molecule. That work resulted in a Nobel Prize in 1972. Edelman has also made important contributions to our understanding of cell adhesion molecules, especially those that guide brain development. The immune system makes specific antibodies to an infinite diversity of antigens. Contrary to expectation, the immune cells do not design de novo specific antibodies to fit the antigen's shape. Instead, preexisting clones, which already bear suitable antibodies, are "selected" by their binding to the antigen. The selected clones proliferate. Future exposures
The Role of Dynamic Plantar Pressures in Diabetic Foot Ulcers
Authors: Richard M Stess, Shayne R Jensen, Roya Mirmiran
Journal: Diabetes Care (1997)

OBJECTIVE The significance of plantar pressure studies in detecting sites of plantar ulceration in diabetic patients was investigated. RESEARCH DESIGN AND METHODS A total of 97 diabetic patients participated in this study. History and physical data, such as history of smoking, type of diabetes, ankle/brachial indexes, and the presence of protective sensory threshold, were collected. Using the EMED-SF plantar pressure analyzer, dynamic pressure variables, such as normalized peak pressure of maximum pressure picture (MPP), pressure-time integral (PTI), and force-time integral (FTI), were measured in each foot. Statistical analysis included descriptive statistics and analyses of variance. RESULTS Out of 97 patients, 34 patients had no history of neuropathy and plantar ulceration (the diabetic control [DC] group). Another 14 patients had neuropathy with no previous history of plantar ulcers (the DN group), whereas the remainder of the patients had a history of peripheral neuropathy with plantar ulceration (the DU group). There were significant increases in MPP (P &amp;lt; 0.004) and PTI (P &amp;lt; 0.0004) levels in the DU group when compared with the DC group with the highest pressure present under the 4th and 5th metatarsal heads. No statistical significance existed among groups when comparing FTI levels. CONCLUSIONS Neuropathic patients have an increase in dynamic plantar foot pressures placing them at risk for plantar ulceration. Instruments such as the EMED-SF system can be helpful in detecting possible sites of plantar ulcerations by locating the areas of maximum pressure.
Orbital Accumulation of Gallium-67 Citrate
Authors: JANE L. TYLER
Journal: Clinical Nuclear Medicine (1983)

In order to determine the normal range of Gallium-67 citrate (Ga-67) accumulation in the orbital regions, and to possibly identify groups tending to have increased Ga-67 concentration in the eyes, 75 studies were performed prospectively over a two-month period. No difference in the ocular count/background ratio was found on the basis of sex, or on the basis of symptomatic ocular involvement in a systemic disease process. A significant difference in this ratio was found between age groups separated by 20 years or more, with younger patients tending to have higher ocular counts. This decrease in the ratio with age possibly reflects the physiologic senile involution of the lacrimal apparatus with time. The wide range of normal ocular Ga-67 accumulation should be kept in mind, and demonstrable Ga-67 concentration in the orbital regions need not be automatically ascribed to a pathologic process.
Computerized Axial Tomography
Authors: Leon Menzer
Journal: JAMA (1975)

COMPUTERIZED axial tomography (CT) of the brain is a new and important neuroradiologic technique developed by G. H. Hounsfield, a senior research electronic physicist working at EMI Laboratories, Middlesex, and James Ambrose, MD, a neuroradiologist at the Atkinson Morley's Hospital, London, England. The technique couples an x-ray tube with a computer and demonstrates the normal and pathologic anatomy of the brain in horizontal sections. The value of this technique in the diagnosis of brain abnormalities has been discussed by Ambrose<sup>1</sup>and others. It is the purpose of this communication to emphasize the usefulness of CT in the diagnosis of behavioral abnormalities generally classified under the term "dementia." Furthermore, we will demonstrate that it is now possible in many instances to investigate serious neurologic disorders without resorting to hospitalization, thereby avoiding dangerous neuroradiologic procedures. <h3>THE EMI SCANNER</h3> The patient is placed supine on an adjustable couch, and his head is
A single night time dose of ranitidine in the acute treatment of gastric ulcer: a European multicentre trial.
Authors: F P Ryan, R Jorde, R S Ehsanullah, K Summers, J R Wood
Journal: Gut (1986)

Four hundred and twenty eight patients with endoscopically diagnosed gastric ulcers, randomly allocated to treatment with ranitidine 300 mg at night or ranitidine 150 mg twice daily, were evaluated in a double blind multicentre trial conducted in 10 European countries. After four weeks, complete ulcer healing was observed in 138 of 211 patients (65%) treated with ranitidine 300 mg nocte and in 155 of 217 patients (71%) receiving 150 mg bd. Cumulative healing rates at eight weeks were 90% and 93%, respectively. There was no statistically significant difference between the healing rates at either four or eight weeks. The treatment regimens were equally effective at rapidly reducing the incidence of ulcer related symptoms. Adverse events reported were minor and equally distributed between the two groups. The results of this trial show that 300 mg of ranitidine administered at night is an effective and safe alternative to the current twice daily regimen for the short term treatment of gastric ulcer.
Sacro-iliac Strain
Authors: T. T. Stamm
Journal: BMJ (1955)

MEDICAL JOURNAL.iInvestigations.-X-rayexamination showed clear lung fields and an area of bone resorption in the body of the right pubic bone; adjacent bones were normal.A blood count showed red cells, 5,900,000; Hb, 116% ; C.I., 0.99; white cells, 11,000 (polymorphs 80%, lymphocytes 13.3%, mono- cytes 6.7%); E.S.R., 17 mm.per hour (Wintrobe).The temperature and pulse
Relation between arterial pressure, dietary sodium intake, and renin system in essential hypertension.
Authors: P S Parfrey, N D Markandu, J E Roulston, B E Jones, J C Jones, G A MacGregor
Journal: BMJ (1981)

Forty-one patients with mild essential hypertension, 36 patients with severe hypertension, and 28 normotensive subjects were studied on a high sodium intake of 350 mmol/day for five days and low sodium intake of 10 mmol/day for five days. The fall in mean arterial pressure on changing from the high-sodium to the low-sodium diet was 0.7 +/- 1.7 mm Hg in normotensive subjects, 8 +/- 1.4 mm Hg in patients with mild hypertension, and 14.5 +/- 1.4 mm Hg in patients with severe hypertension. The fall in blood pressure was not correlated with age. Highly significant correlations were obtained for all subjects between the ratio of the fall in mean arterial pressure to the fall in urinary sodium excretion on changing from a high- to a low-sodium diet and (a) the level of supine blood pressure on normal diet, (b) the rise in plasma renin activity, and (c) the rise in plasma aldosterone. In patients with essential hypertension the blood pressure is sensitive to alterations in sodium intake. This may be partly due to some change either produced by or associated directly with the hypertension. A decreased responsiveness of the renin-angiotensin-aldosterone system shown in the patients with essential hypertension could partly account for the results.
DNAM-1, A Novel Adhesion Molecule Involved in the Cytolytic Function of T Lymphocytes
Authors: Akira Shibuya, David Campbell, Charles Hannum, Hans Yssel, Karin Franz-Bacon, Terrill McClanahan, Toshio Kitamura, Jillian Nicholl, Grant R Sutherland, Lewis L Lanier, Joseph H Phillips
Journal: Immunity (1996)
Determination of cerebral perfusion by means of planar brain scintigraphy and99mTc-HMPAO in brain death, persistent vegetative state and severe coma
Authors: H. -P. Schlake, I. G. Böttger, K. -H. Grotemeyer, I. W. Husstedt, W. Brandau, O. Schober
Journal: Intensive Care Medicine (1992)
Single Fiber Recording of the Ventricular Response to Induced Hypothermia in the Anesthetized Dog
Authors: THEODORE C. WEST, EVAN L. FREDERICKSON, DAVID W. AMORY
Journal: Circulation Research (1959)

Ventricular membrane Potentials were recorded by the microelectrode technic in anesthetized, open-chest dogs. Concurrently, intraventricular pressure, electrocardiogram and esophageal temperature were recorded. Hypothermia was induced by an extracorporeal cooling method. Data on the parameters observed are presented for a temperature range from 38 to 22 C. The mean temperature for spontaneous ventricular fibrillation was approximately 22 C. Hypothermia increased single fiber action potential duration, primarily by prolonging the plateau phase. Depolarization and terminal repolarization were less affected. Action potential amplitude and resting potential were not changed. Change in action potential duration as a function of varying heart rate became more pronounced with cooling. A characteristic change in action potential shape during early repolarization became evident as hypothermia progressed. Hypothermic changes in the single fiber action potential are compared with changes in the electrocardiogram and the pressure curve. Recordings made from single fibers during hypothermic ventricular fibrillation showed a marked shortening in action potential duration.
Influenza virus-specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infection.
Authors: M B Graham, V L Braciale, T J Braciale
Journal: The Journal of Experimental Medicine (1994)

T lymphocytes play a primary role in recovery from viral infections and in antiviral immunity. Although viral-specific CD8+ and CD4+ T cells have been shown to be able to lyse virally infected targets in vitro and promote recovery from lethal infection in vivo, the role of CD4+ T lymphocytes and their mechanism(s) of action in viral immunity are not well understood. The ability to further dissect the role that CD4+ T cells play in the immune response to a number of pathogens has been greatly enhanced by evidence for more extensive heterogeneity among the CD4+ T lymphocytes. To further examine the role of CD4+ T cells in the immune response to influenza infection, we have generated influenza virus-specific CD4+ T cell clones from influenza-primed BALB/c mice with differential cytokine secretion profiles that are defined as T helper type 1 (Th1) clones by the production of interleukin 2 (IL-2) and interferon gamma (IFN-gamma), or as Th2 clones by the production of IL-4, IL-5, and IL-10. Our studies have revealed that Th1 clones are cytolytic in vitro and protective against lethal challenge with virus in vivo, whereas Th2 clones are noncytolytic and not protective. Upon further evaluation of these clonal populations we have shown that not only are the Th2 clones nonprotective, but that pulmonary pathology is exacerbated as compared with control mice as evidenced by delayed viral clearance and massive pulmonary eosinophilia. These data suggest that virus-specific CD4+ T cells of the Th2 subset may not play a primary role in virus clearance and recovery and may lead to immune mediated potentiation of injury.
Septal geometry in the unloaded living human heart.
Authors: J A Lima, P A Guzman, F C Yin, R K Brawley, L Humphrey, T A Traill, S D Lima, P Marino, M L Weisfeldt, J L Weiss
Journal: Circulation (1986)

Right ventricular loading leads to diastolic septal flattening in man without necessarily requiring right ventricular pressure to exceed left ventricular pressure. This observation suggested that the unstressed septal configuration is flat and that its normal concave shape is due to the left-to-right transseptal pressure gradient. To examine this hypothesis, we studied septal configuration by two-dimensional echocardiography in nine patients with normal global and regional left ventricular function during surgery for coronary artery disease. The transseptal pressure gradient was obtained from pulmonary capillary wedge pressure minus right atrial pressure. Measurements were obtained at control (open chest, intact pericardium [C]), with the pericardium open (OP), on cardiopulmonary bypass (CPB), and after cardiac arrest (CA). There were no changes in any measurements between C and OP or between CPB and CA. Left ventricular end-diastolic cavity area decreased from 16.5 +/- 2.1 cm2 at C to 11.1 +/- 4.5 cm2 after CPB, and further decreased to 8.9 +/- 3.5 cm2 after CA (p less than .001), yet the septum flattened, as shown by an increase in its radius of curvature from 1.7 +/- 0.5 cm during C to 2.5 +/- 0.7 cm after CPB, and to 2.9 +/- 1.0 cm after CA (p less than .001), or from 0.4 +/- 0.1 to 0.8 +/- 0.4 to 1.1 +/- 0.5 U (p less than .001) when normalized for cavity area. Diastolic transseptal pressure gradient was reduced from 4.1 +/- 2.3 mm Hg during C to 1.1 +/- 1.8 mm Hg after CPB, and to 0.5 +/- 1.4 mm Hg after CA (p less than .01).(ABSTRACT TRUNCATED AT 250 WORDS)
Analysis of the distribution of time that patients spend in emergency departments
Authors: Thomas E Locker, Suzanne M Mason
Journal: BMJ (2005)

Our results do not support previous data suggesting an inverse association between two common enteric infections and adult atopy.The proportions of samples that were Phadiatop positive were similar in men with and without serological evidence of past hepatitis A infection (37% v 34%) and Helicobacter pylori infection (40% v 36%).Two other markers of childhood infection available from questionnaire data-number of siblings and whether a man went to boarding school-also showed no association with Phadiatop positivity. CommentOur data show that atopy in middle aged men has increased during the last quarter of the 20th century and that the prevalence of atopy does not decline with increasing age; rather, more recent birth cohorts are more likely to have become atopic.Reports of increases over time in specific IgE to inhaled allergens in adults from Nordic countries and Swiss and Japanese schoolchildren 1-4 involved younger subjects and shorter time periods than ours.The reason for the increase in atopy is unknown.Our data suggest that it is unlikely to be an increased exposure to specific allergens (because sensitivity to both indoor and outdoor allergens increased).Our results also do not support the increase being due to declining childhood infections.We thank the BUPA Foundation for support for maintaining the serum samples and database.
Abstract P5-20-13: Preliminary report of a phase I/II study of entinostat (IND#NSC 706995, /M275) and lapatinib (IND#NSC 727989) in patients with HER2-positive metastatic breast cancer in whom trastuzumab has failed
Authors: NT Ueno, SA Jackson, RH Alvarez, JS Willey, GN Hortobagyi, AM Angulo-Gonzalez, SH Giordano, DJ Booser, V Valero
Journal: Cancer Research (2012)

Abstract Background: Entinostat is a novel, potent, orally bioavailable, class I selective histone deacetylase inhibitor. Pre-clinical data has shown that Entinostat can enhance the activity of Lapatinib in HER2+ metastatic inflammatory and non-inflammatory breast cancer. The primary objective of the phase I portion of this study is to determine the recommended phase II dose for Entinostat in combination with Lapatinib in patients who have received Trastuzumab for HER2+ metastatic breast cancer. Methods: This is a single center, open-label study to evaluate the safety and tolerability of every other week entinostat in combination with a 28-day cycle of Lapatinib. Patients with metastatic breast cancer in whom trastuzumab has failed were included. The phase I portion of the study is a conventional 3+3 dose-escalation design. Dose levels include 0 (starting dose) Entinostat 10 mg orally every other week, I Entinostat 12 mg, and II Entinostat 15 mg. Lapatinib 1,250 mg orally is given every day without dose escalation. Toxicities are evaluated at the end of each cycle. Results: Here we report the phase I portion of the study. To date, 9 patients were enrolled, 3 were in level 0, and 6 were in level I. In Level 0, 2 patients were taken off study due to disease progression (PD) at the end of cycle one and 1 patient was taken off study due to PD at the end of cycle two. In Level I, 1 patient was taken off study due to PD at the end of cycle one and 2 patients were taken off study due to PD at the end of cycle 2. 1 patient had stable disease. The median age is 41 (range, 26–69). Seven of the nine patients are evaluable for toxicity. Most common toxicities reported by the patients are nausea grade 3 (1), fatigue grade 3 (1), muscle aches/pain grade 2 (3), skin rash grade 3 (1), paresthesias grade 2 (2), heartburn grade 1 (4), and diarrhea Grade 2 (1). Lapatinib dose was reduced in 2 patients. The most common hematological toxicities were neutropenia grade 1 (3), anemia grade 2 (1), and thrombocytopenia grade 4 (1). Conclusions: Overall, patients have tolerated the combination regimen relatively well. We have not reached the maximum tolerated dose, so patient enrollment will continue until the phase I portion of the study is complete, most likely in July 2012. We plan to proceed with phase II portion in two parallel cohorts (HER2+ inflammatory and non-inflammatory metastatic breast cancer). Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P5-20-13.
A Magnificent Whole
Authors: John T. Lynn
Journal: Annals of Internal Medicine (1993)

On Being a Doctor15 September 1993A Magnificent WholeJohn T. Lynn, MDJohn T. Lynn, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-6-199309150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I introduced myself, and a touchy silence filled the room. Motorcycle people, I thought, glancing at the patient and his two visitors. My stethoscope felt sticky as I turned to find a chair.With the chart resting on my crossed legs, I asked, What problem are you having, Mr. Hugo?The woman on the other side of the bed replied, He has a bleeding ulcer, but his left knee and foot are what really hurt. Her voice was staccato, yet strangely monotonal. She faced the head of the bed, her profile partly covered by tarry hair. After answering my question, ... Author, Article, and Disclosure InformationAuthors: John T. Lynn, MDCorresponding Author: John T. Lynn III, MD, 801 N. Cascade, Suite 22, Colorado Springs, CO 80903. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 September 1993Volume 119, Issue 6Page: 527KeywordsChartsGoutHemorrhageKneesMouthRashesTouchUlcers ePublished: 15 August 2000 Issue Published: 15 September 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Combination therapy of E-antigen-negative/virus-DNA-positive (precore mutant) chronic hepatitis B with famciclovir or lamivudine and interferon (IFN) alfa-2a
Authors: I. Schiefke, U. Oesen, G. Etzrodt, M. Wiedmann, U.G. Liebert, J. Moessner, F. Berr
Journal: Journal of Hepatology (2000)
Serum immunoglobulins in juvenile rheumatoid arthritis.
Authors: V Houba, R Bardfeld
Journal: Annals of the Rheumatic Diseases (1969)

Juvenile rheumatoid arthritis (JRA) differs in many aspects from its adult counterpart (Edstrom, 1958); one of the differences is a low incidence of positive sero-reactions for rheumatoid factors (RF) in patients with JRA (Bywaters, Carter, and Scott, 1959; Sievers, Ahvonen, Aho, and
Hemolytic Reaction Due to Anti-Jkb
Authors: E. Stephen Kurtides
Journal: JAMA (1966)

THE TRANSFUSION of ABO and Rh incompatible blood should never occur, yet reactions to so-called compatible blood are being reported with increasing frequency. Such episodes present a diagnostic challenge and raise serious doubts about our understanding of blood group incompatibility. The purpose of this paper is to report a case of delayed hemolytic reaction occurring eight days after the transfusion of the last of eight units of apparently compatible blood. Although antibodies were not detected at the time of the transfusions, three were identified thereafter. <h3>Report of a Case</h3> A 58-year-old white man was admitted to the Evanston Hospital on Sept 9, 1965, because of gastrointestinal hemorrhage. He gave a history of duodenal ulcer of 23 years' duration with episodes of bleeding in 1942 and 1947. He had received 3 units of whole blood in 1947. The patient's blood type was group O, Rh negative (cde). The hemoglobin level on