tbuckley/cabot-search huggingface dataset:
Studies of Human Intrinsic Factor Auto-Antibodies.
Authors: M. D. Turner
Journal: Annals of Internal Medicine (1967)

s1 May 1967Studies of Human Intrinsic Factor Auto-Antibodies.M. D. Turner, M.D., G. O. Garrido-Pinson, M.D., I. Michael Samloff, M.D., Harry L. Segal, M.D., F.A.C.P.M. D. Turner, M.D.Search for more papers by this author, G. O. Garrido-Pinson, M.D.Search for more papers by this author, I. Michael Samloff, M.D.Search for more papers by this author, Harry L. Segal, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1027_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrevious studies from this and other laboratories have shown evidence for the existence of two distinct types of autoantibody to human intrinsic factor in the sera of some patients with pernicious anemia.The antibodies vary in amount independently of one another. The first type of antibody ("blocking" antibody) reacts with intrinsic factor to prevent subsequent formation of the B12-intrinsic factor complex. The antibody is incapable of reacting with the preformed intrinsic factor-B12complex and does not displace the vitamin B12from such a complex. This antibody is detected by the charcoal adsorption assay. The second type ("binding" antibody) reacts either... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: M. D. Turner, M.D.; G. O. Garrido-Pinson, M.D.; I. Michael Samloff, M.D.; Harry L. Segal, M.D., F.A.C.P.Affiliations: Rochester, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1967Volume 66, Issue 5Page: 1027-1027KeywordsAntibodiesAutoantibodiesPernicious anemia ePublished: 1 December 2008 Issue Published: 1 May 1967 PDF downloadLoading ...
Humanizing the Mouse: In Defense of Murine Models of Critical Illness
Authors: Harris Perlman, G. R. Scott Budinger, Peter A. Ward
Journal: American Journal of Respiratory and Critical Care Medicine (2013)

How do we evaluate how well the Journal is succeeding?By utilizing objective metrics to assess impact, reputation, and value to the scientific community.The American Thoracic Society journals were recently reviewed by an advisory committee, who positively evaluated our performance and provided specific recommendations to promote future growth and improvements.Figure 3 presents the data on downloads of content from the AJRCCM website in the past several years.This steady increase reflects the growing impact of the Journal and the way it is accessed.This also reflects the fact that the Journal is read broadly and is relevant to a great number of clinicians and scientists in our field.We are rightfully proud of the position of the AJRCCM as the premier journal in our specialty.We look forward to continuing its improvement through new initiatives from our Editors, ATS-sponsored workshops, external advisors, and the ATS leadership.We must continue to adapt as new technological innovations present novel opportunities to disseminate and publish the best science in our field.We also look to you, our readers, for feedback on how the Journal can meet and anticipate your needs.Thank you for giving us the opportunity to be of service to you.
Cancer Stem Cell Vaccination Confers Significant Antitumor Immunity
Authors: Ning Ning, Qin Pan, Fang Zheng, Seagal Teitz-Tennenbaum, Martin Egenti, Ji Yet, Mu Li, Christophe Ginestier, Max S. Wicha, Jeffrey S. Moyer, Mark E.P. Prince, Yingxin Xu, Xiao-Lian Zhang, Shiang Huang, Alfred E. Chang, Qiao Li
Journal: Cancer Research (2012)

Abstract Most studies of cancer stem cells (CSC) involve the inoculation of cells from human tumors into immunosuppressed mice, preventing an assessment on the immunologic interactions and effects of CSCs. In this study, we examined the vaccination effects produced by CSC-enriched populations from histologically distinct murine tumors after their inoculation into different syngeneic immunocompetent hosts. Enriched CSCs were immunogenic and more effective as an antigen source than unselected tumor cells in inducing protective antitumor immunity. Immune sera from CSC-vaccinated hosts contained high levels of IgG which bound to CSCs, resulting in CSC lysis in the presence of complement. CTLs generated from peripheral blood mononuclear cells or splenocytes harvested from CSC-vaccinated hosts were capable of killing CSCs in vitro. Mechanistic investigations established that CSC-primed antibodies and T cells were capable of selective targeting CSCs and conferring antitumor immunity. Together, these proof-of-concept results provide a rationale for a new type of cancer immunotherapy based on the development of CSC vaccines that can specifically target CSCs. Cancer Res; 72(7); 1853–64. ©2012 AACR.
Oxaliplatin-Related Neurotoxicity: Interest of Calcium-Magnesium Infusion and No Impact on Its Efficacy
Authors: Laurence Gamelin, Michèle Boisdron-Celle, Alain Morel, Anne Lise Poirier, Virginie Berger, Erick Gamelin, Christophe Tournigand, Aimery de Gramont
Journal: Journal of Clinical Oncology (2008)
Immunohistochemical and virological study of skin in the papular-purpuric gloves and socks syndrome
Authors: S. ARACTINGI, D. BAKHOS, B. FLAGEUL, O. VÉROLA, M. BRUNET, L. DUBERTRET, F. MORINET
Journal: British Journal of Dermatology (1996)

The pathogenesis of viral exanthems remains unclear. We have undertaken an immunohistochemical study of lesional skin biopsies in patients with the papular-purpuric gloves and socks syndrome (PPGSS) secondary to parvovirus B19 infection. Intracytoplasmic staining of the dermal endothelial cells, keratinocytes, and sweat glands was shown with an antibody to parvovirus B19. There were perivascular dermal infiltrates with T cells, sometimes with exocytosis. By polymerase chain reaction, virus DNA was detected in all skin biopsies and in one serum sample. The cutaneous manifestations of parvovirus infection seem secondary to infection of the endothelium and epidermis.
Interpretation of screening test results: Best performers have the most to learn
Authors: Mark R Nelson
Journal: BMJ (2006)

Editor-Gornall is correct to raise the issue of Roy Meadow's and David Southall's omission from the reference list in the Child Protection Companion. 1 2 Southall, along with others, made contributions to the sections on fabricated and induced illness and imposed airway obstruction in chapter 6 of the Companion.Considerable notice was taken of Southall's views on these topics.The editorial group discussed how to manage the references throughout the book and, for these sections, chose to reference only the two documents on fabricated and induced illness produced by the Royal College of Paediatrics and Child Health (2002) and the Department of Health (2002).We think that these documents covered the topic and referenced all the essential authors on this topic.In retrospect, however, the lack of appropriate reference to both Southall and Meadow is unsatisfactory, and their important work should have been acknowledged more fully.Unfortunately, at the time of the preparation of the content of the Companion, the two professors were involved in the disciplinary process of the General Medical Council, which has still not been concluded in relation to Meadow and which reached an unfavourable outcome with regard to Southall.We debated their difficult situation.We were concerned for them as individuals, particularly as they have both worked tirelessly in promoting the welfare and safety of children.We were also concerned about the outcome of the GMC hearings.We recognised the potential impact that an adverse outcome would have on the retention and recruitment of paediatricians into child protection and also considered any implications for the Companion, which we were in the process of producing.It is possible that had we referenced the two professors more fully, this could have provided lawyers and journalists with ammunition to undermine the value of the Companion.We were always mindful of the objectives that we had set ourselves in producing the Companion.It was never intended to be a fully referenced textbook, and many seminal papers are therefore not referenced.
795 PROGNOSTIC FACTORS AMONG PATIENTS WITH HEPATOCELLULAR CARCINOMA (HCC) TREATED BY Y90-RADIOEMBOLIZATION (Y90-RE)
Authors: M. Iñarrairaegui, D. D'Avola, M. Rodriguez, J.I. Bilbao, A. Martinez-Cuesta, F. Alegre, I. Herrero, J. Quiroga, J. Prieto, B. Sangro
Journal: Journal of Hepatology (2009)
If we could talk to the animals
Authors: Michael Siegal, Rosemary Varley
Journal: Behavioral and Brain Sciences (2008)

Abstract The thesis of discontinuity between humans and nonhumans requires evidence from formal reasoning tasks that rules out solutions based on associative strategies. However, insightful problem solving can be often credited through talking to humans, but not to nonhumans. We note the paradox of assuming that reasoning is orthogonal to language and enculturation while employing the criterion of using language to compare what humans and nonhumans know.
Obstetric care and proneness of offspring to suicide as adults: case-control study
Authors: B. Jacobson, M. Bygdeman
Journal: BMJ (1998)

<h3>Abstract</h3> <b>Objective:</b> To investigate any long term effects of traumatic birth and obstetric procedures in relation to suicide by violent means in offspring as adults. <b>Design:</b> Prospective case-control study. <b>Setting:</b> Stockholm, Sweden. <b>Subjects:</b> 242 adults who committed suicide by violent means from 1978&nbsp;to 1995,&nbsp;and who were born in one of seven hospitals in Stockholm during 1945-80,&nbsp;matched with 403&nbsp;biological siblings born during the same period and at the same group of hospitals. <b>Main outcome measures:</b> Adverse and beneficial perinatal factors expressed as relative risks (odds ratios) and 95% confidence intervals, derived from logistic regression of cases matched with their siblings. <b>Results:</b> For multiple birth trauma the estimated relative risks of offspring subsequently committing suicide by violent means were 4.9&nbsp;(95% confidence interval 1.8&nbsp;to 13) for men and 1.04&nbsp;(0.2&nbsp;to 4.6) for women. In mothers who received multiple opiate treatment during delivery, the estimated relative risk of offspring subsequently committing suicide was equal for both sexes (0.26,&nbsp;0.09&nbsp;to 0.69). <b>Conclusion:</b> Minimising pain and discomfort to the infant during birth seems to be of importance in reducing the risk of committing suicide by violent means as an adult.
Five-Year Follow-up Survey of an Outbreak of Staphylococcal Infection in a Hospital Nursery
Authors: Valerie Hurst, Moses Grossman, Vera L. Sutter, Jean Fennell
Journal: New England Journal of Medicine (1964)

IN the spring of 1957 an outbreak of staphylococcal impetigo occurred in our nursery. Type 80/81 was recovered from the lesions, and about one third of the infants were found to carry this strain asymptomatically. Within the next few months it became apparent that the infants and their families were experiencing frequent and often recurrent Type 80/81 staphylococcal disease at home.1 A clinical and bacteriologic survey, conducted in 1958, indicated that 65 per cent of the families contained members who had become carriers or had experienced staphylococcal disease within sixteen months of the outbreak.2 In 1962 a second survey was . . .
Death effector domain–containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice
Authors: Mayumi Mori, Miwako Kitazume, Rui Ose, Jun Kurokawa, Kaori Koga, Yutaka Osuga, Satoko Arai, Toru Miyazaki
Journal: Journal of Clinical Investigation (2010)

During intrauterine life, the mammalian embryo survives via its physical connection to the mother. The uterine decidua, which differentiates from stromal cells after implantation in a process known as decidualization, plays essential roles in supporting embryonic growth before establishment of the placenta. Here we show that female mice lacking death effector domain-containing protein (DEDD) are infertile owing to unsuccessful decidualization. In uteri of Dedd-/- mice, development of the decidual zone and the surrounding edema after embryonic implantation was defective. This was subsequently accompanied by disintegration of implantation site structure, leading to embryonic death before placentation. Polyploidization, a hallmark of mature decidual cells, was attenuated in DEDD-deficient cells during decidualization. Such inefficient decidualization appeared to be caused by decreased Akt levels, since polyploidization was restored in DEDD-deficient decidual cells by overexpression of Akt. In addition, we showed that DEDD associates with and stabilizes cyclin D3, an important element in polyploidization, and that overexpression of cyclin D3 in DEDD-deficient cells improved polyploidization. These results indicate that DEDD is indispensable for the establishment of an adequate uterine environment to support early pregnancy in mice.
Vaginal Bleeding in Chorionepithelioma
Authors: D. B. Bower, K. D. Bagshawe, R. A. L. Brewis
Journal: BMJ (1965)

phosphoric compounds change in the plant or in the animal into new, often unidentifiable, substances of the greatest toxicity.In these cases absence of the original insecticide on analysis does not prove the absence of the most toxic unidentified substances derived from it.Another problem is presented by the highly toxic chlorinated-hydrocarbons (aldrin,
Oral Administration of Cortisone in a Case of Erythema Nodosum
Authors: Alvin L. Ureles, R. Bruce Kalmansohn
Journal: New England Journal of Medicine (1951)

IT HAS long been known that erythema nodosum occurs in association with tuberculosis and rheumatic fever.1 , 2 Within recent years clinicians have often noted its relation to such varied diseases as streptococcal infections,2 coccidioidomycosis,3 meningococcemia,4 influenza,5 ulcerative colitis6 and drug reactions.7 Because of its association with this wide spectrum of disease, erythema nodosum has been considered a manifestation of hypersensitivity.8 Since cortisone has been observed to have dramatic effects on hypersensitivity states,9 it was considered of interest to utilize this drug in the treatment of erythema nodosum.The present report describes the immediate and striking response to orally administered cortisone observed . . .
Two cases of nicorandil‐induced ulceration mimicking skin malignancy
Authors: A. Sharma, S. Orpin, J. Goulding, M. Kaur
Journal: British Journal of Dermatology (2014)

Journal Article Two cases of nicorandil‐induced ulceration mimicking skin malignancy Get access A. Sharma, A. Sharma Department of Dermatology Heart of England NHS Trust Solihull Hospital Lode Lane Solihull B92 2JL U.K Search for other works by this author on: Oxford Academic Google Scholar S. Orpin, S. Orpin Department of Dermatology Heart of England NHS Trust Solihull Hospital Lode Lane Solihull B92 2JL U.K Search for other works by this author on: Oxford Academic Google Scholar J. Goulding, J. Goulding Department of Dermatology Heart of England NHS Trust Solihull Hospital Lode Lane Solihull B92 2JL U.K Search for other works by this author on: Oxford Academic Google Scholar M. Kaur M. Kaur Department of Dermatology Heart of England NHS Trust Solihull Hospital Lode Lane Solihull B92 2JL U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 171, Issue 3, 1 September 2014, Pages 662–663, https://doi.org/10.1111/bjd.12978 Published: 01 September 2014
Body Image in the Balance
Authors: Michael J. Devlin, April J. Zhu
Journal: JAMA (2001)

This article explores how distress over body image can impact on mental health, both emotionally and psychologically. It also looks at the issue of gender and body image. While body image distress is on the rise among men, women are predominantly affected. Other issues such as media influence, eating disorders, pathological dieting, cognitive behavioural therapy and body ideals. Research shows that extreme dieting behaviours and eating disorders are on the increase due to increasing body dissatisfaction. Cognitive behavioral therapy has been shown to improve body image even in the absence of weight loss and can complement behavioral and dietary strategies in weight management. The author concludes that a person's self-regard is a key component of her overall health and well-being.
Ascending aortic impedance patterns in the kangaroo: their explanation and relation to pressure waveforms.
Authors: W W Nichols, A P Avolio, M F O'Rourke
Journal: Circulation Research (1986)

This study seeks to explain mechanisms responsible for the peculiar ascending aortic pressure waveform and impedance spectral pattern in kangaroos. Pulsatile pressure and blood flow velocity were measured and input impedance calculated in the ascending aorta, descending thoracic aorta, and brachiocephalic artery of 15 rock kangaroos. Pressure and velocity waveforms and impedance spectral patterns were interpreted with the aid of an asymmetric uniform T-tube model of the systemic arterial tree. The ascending aortic pressure waveform displayed a very large secondary wave that began in late systole or early diastole and continued throughout most of diastole. The peak of this secondary wave (which almost always occurred in diastole) was often greater than peak systolic pressure and results from apparently intense wave reflections from peripheral vascular beds. This contention is supported by the configuration of the impedance spectral pattern that is explained on the basis of a single (or dominant) functionally discrete reflecting site in the lower part of the body. These findings are explicable on the basis of body size and shape and the extreme eccentric location of the heart within the body. Wave reflections from the diminutive upper body are so small that they are totally dominated by intensive wave reflections from the large muscular lower body. These conclusions are supported by results obtained from the asymmetric T-tube model.
Fulminant hepatic failure: Summary of a workshop
Authors: Jay H. Hoofnagle, Robert L. Carithers, Craig Shapiro, Nancy Ascher
Journal: Hepatology (1995)

Fulminant hepatic failure (FHF) is defined by the appearance of severe liver injury with hepatic encephalopathy in a previously healthy person. There are an estimated 2,000 cases of FHF in the United States yearly, representing 0.1% of all deaths and, perhaps, 6% of liver-related deaths. The causes of FHF are many, the chief ones in the United States being hepatitis A; B; non-A, non-B and drug induced liver disease. There are no specific therapies for FHF, however, liver transplantation is recommended for situations in which spontaneous recovery appears unlikely. Factors that are valuable in assessing the likelihood of spontaneous recovery are static features such as patient age and etiology of FHF and dynamic features including encephalopathy grade, prothrombin time, and serum bilirubin. Presently, approximately 7% of all liver transplants are done for FHF and the 1-year patient survival rates average 63%, somewhat less than survival rates for nonfulminant liver disease, averaging 78%. The management of patients with FHF is challenging, particularly important being monitoring and early treatment of infections, hemodynamic abnormalities, and brain edema. Innovative approaches to management and therapy include use of cytoprotective or antiviral medications, hepatic support systems, extracorporeal liver support, hepatocyte transplantation, auxiliary liver transplantation, and xenotransplantation. None of these are of proven benefit, but many are promising as a means to support the patient with FHF until spontaneous recovery occurs or a suitable liver graft is available for transplantation.
GP is suspended for six months for failing to make an urgent referral
Authors: C. Dyer
Journal: BMJ (2012)

<h3>Objective</h3> The aim of this study was to investigate the attitudes of general practitioners (GPs) to the development of a national diabetes register as a way of improving the quality of care. <h3>Design</h3> Qualitative study using semistructured interviews. <h3>Setting</h3> General practice, Ireland. <h3>Participants</h3> Purposive sample of 29 GPs and two practice nurses. Participants’ practices varied by (a) location (rural/urban), (b) size (single-handed/group practice) and (c) extent of computerisation. <h3>Methods</h3> The semistructured topic guide focused on experiences of change in the health system at a local and national level and attitudes towards the development of a national diabetes register. Analysis was conducted using the Framework approach. <h3>Results</h3> Participants were sceptical about the development of a national diabetes register. The main advantage was ‘knowing the numbers’ for epidemiological and policy purposes. However, participants questioned the benefits for their practice and patients. There were concerns that it would drain resources from other priorities and distract from patient management. These attitudes were strongly influenced by previous experience of change in the health system. Participants felt that remuneration would be necessary to ensure full engagement, reflecting wider frustrations with payment structures for general practice. There was a sense of wariness towards health service administration which was not specific to diabetes care but which coloured some participants’ attitudes towards a national register. In contrast, participants referred to positive experiences of change at a local level, facilitated by a ‘practice ethos’ and professional leadership. <h3>Conclusions</h3> This study highlights the growing sense of scepticism and inertia towards change within the health system. This inertia stems from previous experience and the competing demands of maintaining versus improving care in a system with dwindling resources.