tbuckley/cabot-search huggingface dataset:
Localized arteriole formation directly adjacent to the site of VEGF-Induced angiogenesis in muscle
Authors: Matthew L Springer, Clare R Ozawa, Andrea Banfi, Peggy E Kraft, Tze-Kin Ip, Timothy R Brazelton, Helen M Blau
Journal: Molecular Therapy (2003)

We have shown previously that implantation of myoblasts constitutively expressing the VEGF-A gene into nonischemic mouse skeletal muscle leads to overgrowth of capillary-like blood vessels and hemangioma formation. These aberrant effects occurred directly at the implantation site. We show here that these regions result from angiogenic capillary growth and involve a change in capillary growth pattern and that smooth muscle-coated vessels similar to arterioles form directly adjacent to the implantation site. Myoblasts genetically engineered to produce VEGF were implanted into mouse leg muscles. Implantation sites were surrounded by a zone of dense capillary-sized vessels, around which was a second zone of muscle containing larger, smooth-muscle-covered vessels but few capillaries, and an outer zone of muscle exhibiting normal capillary density. The lack of capillaries in the middle region suggests that the preexisting capillaries adjacent to the implantation site underwent enlargement and/or fusion and recruited a smooth muscle coat. Capillaries at the implantation site were frequently wrapped around VEGF-producing muscle fibers and were continuous with the circulation and were not observed to include bone-marrow-derived endothelial cells. In contrast with the distant arteriogenesis resulting from VEGF delivery described in previous studies, we report here that highly localized arterioles also form adjacent to the site of delivery.
Diagnosis of Coronary Artery Disease
Authors: L. Larry Gladstone
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 September 1990Diagnosis of Coronary Artery DiseaseL. Larry Gladstone, MDL. Larry Gladstone, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-113-5-410_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editors: In the article by Gibbons and colleagues (1) on the noninvasive identification of severe coronary artery disease, the conclusion that "the modest additional advantage provided by exercise radionuclide angiography for identification of three vessel or left main coronary artery disease in patients with normal resting ECGs would not appear to justify its routine use for this purpose," while interesting, misses a fundamental point from the patient's perspective.Of the 93 patients in the study who had proven left main or three vessel coronary atherosclerosis, routine supine stress testing detected 56 with...Reference1. GibbonsZinsmeisterMillerClements RATI. Supine exercise electrocardiography compared with exercise radionuclide angiography in noninvasive identification of severe coronary artery disease. Ann Intern Med. 1990;112:743-9. LinkGoogle Scholar1. GibbonsZinsmeisterMillerClements RATI. Supine exercise electrocardiography compared with exercise radionuclide angiography in noninvasive identification of severe coronary artery disease. Ann Intern Med. 1990;112:743-9. LinkGoogle Scholar2. O'KeefeZinsmeisterGibbons JAR. Value of normal electrocardiographic findings in predicting resting left ventricular function in patients with chest pain and suspected coronary artery disease. Am J Med. 1989;86:648-62. CrossrefGoogle Scholar3. BonowKentRosing RKD. Exercise-induced ischemia in mildly symptomatic patients with coronary-artery disease and preserved left ventricular function. Identification of subgroups at risk of death during medical therapy. N Engl J Med. 1984;311:1339-45. CrossrefMedlineGoogle Scholar4. WeinerRyanMcCabe DTC. The role of exercise testing in identifying patients with improved survival after coronary artery bypass surgery. J Am Coll Cardiol. 1986;8:741-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1990Volume 113, Issue 5Page: 410-411KeywordsAngiographyExerciseStable coronary artery disease Issue Published: 1 September 1990 PDF DownloadLoading ...
Acute abdominal pain in childhood: analysis of a year's admissions.
Authors: H. S. Winsey, P. F. Jones
Journal: BMJ (1967)

In a group of 500 children under 12 years of age two will in the course of a year develop acute abdominal pain that is severe -rnough to require admission to hospital; one will require laparotomy, the other will not. Present InvestigationThis statement, based on the findings of this survey, illustrates the well-known fact that, although acute abdominal pain is fairly common in childhood, many children recover without operative treatment.The aim of this investigation was to record all cases of acute abdominal pain as they entered hospital during one year and then, in the light of subsequent developments, to identify those symptoms and signs which had helped most in reaching or rejecting a diagnosis of surgical disease.In doing this we have obtained useful information on the incidence of acute abdominal disease in a known population.The Royal Aberdeen Hospital for Sick Children is the only hospital for children in North-east Scotland and it receives acute abdominal emergencies from a population of about 450,000 people, among whom are about 76,000 children under the age of 12.All patients accepted from the family doctor by telephone are admitted.During 1965 315 children came in with an acute abdominal pain, and for each child a record form was filled up on admission.The reasons for adopting an operative or non-operative line of treatment were recorded.Later, operative findings and the clinical course of all patients were noted, with a final diagnosis.For ease of analysis we have placed each child in one of five groups.Group 1.-This comprised 114 patients with histologically proved acute appendicitis.Group 2.-In 21 children it was impossible to exclude acute Appendicitis, and they were operated on as emergencies.Acute mesenteric adenitis was present in 11, two had appendices containing threadworms, one had had a haemorrhage into an ovarian cyst, one was subsequently found to have paratyphoid fever, and one child with leukaemia had an acute pyogenic infection of the mesenteric glands.In the remaining five children no cause for the abdominal pain was found.
[418] THE REPLICATION LEVEL OF HBV IS ASSOCIATED WITH THE LEVEL OF HEPATOCYTE NUCLEAR FACTOR 4ALPHA AND 3BETA IN THE LIVER OF HBV INFECTED PATIENTS
Authors: Y. Long, H. Tang, C. Liu, F.T. Huang, T.Y. Zhou, F. He, L. Liu, F.J. Liu
Journal: Journal of Hepatology (2007)
Case Illustrative of the Use of the Ophthalmoscope as a Means of Diagnosis
Authors: J. C. Wordsworth
Journal: BMJ (1861)

of a case of pericarditis, states that he was disappointed by finding the patient make no progress towards re- covery; day by day the rubbing sound remained un- changed.He observed that the patient was oppressed and melancholy, and then discovered that he had great fears as to his spiritual state, and was full of doubts on many points of his religious belief.Under these circumstances, Dr Stokes asked a clergyman distinguished for his talent and eloquence to visit his patient.This interview was followed by the best results.Next day the rubbing sound had become softer; the visit was re- peated, and on the third day all morbid signs had dis- appeared.(Diseases of the Heart and Aorta, 1854, p.22.) CASE VI.I had myself a somewhat similar experi- ence in a case of delirium tremens from drinking.The symptoms exceeded in urgency and obstinacy any reason which could be assigned, and did not coincide with a tolerable appetite and steady digestive powers; they subsided and returned in a very incomprehensible man- ner, notwithstanding the favourable action of opium, and the pulse was often as high as 120.All my in- quiries failed to discover the presence of mental dis.turbance, until one day my patient voluntarily unbur.dened his mind on a subject causing great anxiety and remorse, with every demonstration of intense emotion, and with the confession that he had felt tempted to com- mit suicide.On the next day but one, his whole condition was changed, and his pulse had fallen to 80.[To be continued.]
Pathophysiological Effects of Vascular Endothelial Growth Factor Receptor-2-Blocking Antibody plus Fractionated Radiotherapy on Murine Mammary Tumors
Authors: Bruce M. Fenton, Scott F. Paoni, Ivan Ding
Journal: Cancer Research (2004)

Abstract Although clinical trials of antiangiogenic strategies have been disappointing when administered as single agents, such approaches can play an important role in cancer treatment when combined with conventional therapies. Previous studies have shown that DC101, an antiangiogenic monoclonal antibody against vascular endothelial growth factor receptor-2, can produce significant growth inhibition in spontaneous and transplanted tumors but can also induce substantial hypoxia. Because DC101 appears to potentiate radiotherapy in some tumors, the present studies were undertaken to characterize pathophysiological changes following combined therapy and to determine whether radioresponse is enhanced despite the induction of hypoxia. MCa-4 and MCa-35 mammary carcinomas were treated with: (a) DC101; (b) 5 × 6 Gy radiation fractions; or (c) the combination. Image analysis of frozen tumor sections was used to quantitate: (a) hypoxia; (b) spacing of total and perfused blood vessels; and (c) endothelial and tumor cell apoptosis. For MCa-4, combination treatment schedules produced significant and prolonged delays in tumor growth, whereas single-modality treatments had minor effects. For MCa-35, radiation or the combination led to equivalent growth inhibition. In all tumors, hypoxia increased markedly after either radiation or DC101 alone. Although combination therapy produced no immediate pathophysiological changes, hypoxia ultimately increased after cessation of therapy. Preferential increases in endothelial apoptosis following combination treatment suggest that in addition to blocking tumor angiogenesis, DC101 enhances radiotherapy by specifically sensitizing endothelial cells, leading to degeneration of newly formed blood vessels.
When Depression Doesn’t Lead With Depression
Authors: Michael Craig Miller
Journal: JAMA Psychiatry (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Combination of Fludarabine and Mitoxantrone in Untreated Stages III and IV Low-Grade Lymphoma: S9501
Authors: William S. Velasquez, Danika Lew, Thomas M. Grogan, C. Harris Spiridonidis, Stanley P. Balcerzak, Shaker R. Dakhil, Thomas P. Miller, Keith S. Lanier, Robert A. Chapman, Richard I. Fisher
Journal: Journal of Clinical Oncology (2003)

Purpose: To determine the efficacy of combination fludarabine and mitoxantrone (FN) in untreated stages III and IV low-grade lymphoma. The major end point was to estimate progression-free survival (PFS) in all eligible patients. Patients and Methods: Seventy-eight eligible patients were registered. Chemotherapy courses were administered every 4 weeks with mitoxantrone 10 mg/m 2 on day 1 and fludarabine 25 mg/m 2 on days 1, 2, and 3 for a total of six to eight cycles. Pneumocystis carinii prophylaxis was required. Results: Seventy-three patients (94%) attained an objective response. Complete remission was demonstrated in 34 patients (44%) and partial remission was demonstrated in 39 patients (50%). With a median follow-up time of 5.5 years, the median PFS was 32 months, with a 4-year PFS rate of 38%. Median survival has not been reached and 88% of all patients are alive at 4 years. The application of the International Prognostic Index and serologic staging showed significant differences in PFS in all risk groups, whereas overall survival was markedly worse for the highest-risk group in either prognostic model. Three prior Southwest Oncology Group trials using a regimen of cyclophosphamide, doxorubicin, vincristine, and prednisone or a combination of prednisone, vincristine, methotrexate, cytarabine, cyclophosphamide, etoposide, nitrogen mustard, vincristine, procarbazine, and prednisone in similar patient populations demonstrated comparable clinical outcome, although the 4-year survival for FN was better. FN was well tolerated, but mild to severe reversible myelosuppression was noted. Other complications were rare. Conclusion: FN is an effective, safe chemotherapy combination for patients with advanced-stage, low-grade lymphoma. Clinical outcomes were comparable to prior published data using anthracycline-based regimens.
NICE will retain drug approval role in government U turn
Authors: I. Torjesen
Journal: BMJ (2011)

GPs in commissioning groups in England will not have to make decisions on whether individual drugs are cost effective and whether they should be available on the NHS, after an apparent U turn by the government on its plans to downgrade the role of the National Institute for Health and Clinical Excellence (NICE) in recommending drugs.

Under the health secretary’s original plans, laid down in the draft Health and Social Care Bill, NICE would still have appraised new products but would no longer make a recommendation as to whether they should be funded by the NHS. Instead the government planned to introduce value based pricing in 2014 and negotiate …
Best documented practice
Authors: J. Michaels
Journal: BMJ (1989)

the mean arterial pressure is reasonable.'Measurements of peripheral vascular resistance and cardiac output in our patients confirmed this relation.The diagnosis of electromechanical dissociation in these circumstances is therefore extremely difficult, and resuscitation should not be abandoned until meaningful haemodynamic data have been obtained.Cuff blood pressure is often meaningless in these circumstances, and resuscitation should not be abandoned with this as the sole criterion.I would also remind others of recent British studies that confirm that age alone is not a prognostic indicator for survival from cardiac arrest.4`It is the nature of the underlying rhythm that is of greatest importance.
A Controlled Trial of Leuprolide with and without Flutamide in Prostatic Carcinoma
Authors: E. David Crawford, Mario A. Eisenberger, David G. McLeod, Joseph T. Spaulding, Ralph Benson, F. Andrew Dorr, Brent A. Blumenstein, Marilyn A. Davis, Phyllis J. Goodman
Journal: New England Journal of Medicine (1989)

To test the hypothesis that maximal androgen blockade improves the effectiveness of the treatment of prostatic cancer, we conducted a randomized, double-blind trial in patients with disseminated, previously untreated prostate cancer (stage D2). All 603 men received leuprolide, an analogue of gonadotropin-releasing hormone that inhibits the release of gonadotropins, in combination with either placebo or flutamide, a nonsteroidal antiandrogen that inhibits the binding of androgens to the cell nucleus. As compared with the 300 patients receiving leuprolide and placebo, the 303 patients randomly assigned to receive leuprolide and flutamide had a longer progression-free survival (16.5 vs. 13.9 months; P = 0.039) and an increase in the median length of survival (35.6 vs. 28.3 months; P = 0.035). The differences between the treatments were particularly evident for men with minimal disease and good performance status; however, further studies should be conducted in this subgroup. Symptomatic improvement was greatest during the first 12 weeks of the combined androgen blockade, when leuprolide alone often produces a painful flare in the disease. We conclude that in patients with advanced prostate cancer, treatment with leuprolide and flutamide is superior to treatment with leuprolide alone. (N Engl J Med 1989; 321:419–24.)
Salt Induces Myocardial and Renal Fibrosis in Normotensive and Hypertensive Rats
Authors: Henry C. M. Yu, Louise M. Burrell, M. Jane Black, Leonard L. Wu, Rodney J. Dilley, Mark E. Cooper, Colin I. Johnston
Journal: Circulation (1998)

Background —The detrimental effects of high dietary salt intake may not only involve effects on blood pressure and organ hypertrophy but also lead to tissue fibrosis independently of these factors. Methods and Results —The effect of a normal (1%) or high (8%) sodium chloride diet on myocardial and renal fibrosis was assessed by quantitative histomorphometry in spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto rats (WKYs). The effect of salt on transforming growth factor-β 1 (TGF-β 1 ) gene expression was assessed by Northern blot hybridization. A high-salt diet from 8 to 16 weeks of age resulted in increased blood pressure and left ventricular and renal hypertrophy in both WKYs and SHRs. Marked interstitial fibrosis was demonstrated in the left ventricle (LV), glomeruli, and renal tubules and in intramyocardial arteries and arterioles but not in the right ventricle. The collagen volume fraction increased significantly after high-salt diet in the LV, intramyocardial arteries and arterioles, glomeruli, and peritubular areas in both WKYs and SHRs. In the kidneys, glomerular and peritubular type IV collagen was also increased. There was overexpression of TGF-β 1 mRNA in the LV and kidneys in both rat strains after a high-salt diet (all P &lt;0.001). Conclusions —High dietary salt led to widespread fibrosis and increased TGF-β 1 in the heart and kidney in normotensive and hypertensive rats. These results suggest a specific effect of dietary salt on fibrosis, possibly via TGF-β 1 –dependent pathways, and further suggest that excessive salt intake may be an important direct pathogenic factor for cardiovascular disease.
Risk Factors for Mortality in Patients Undergoing Percutaneous Endoscopic Gastrostomy
Authors: A. Lang, E. Bardan, Y. Chowers, E. Sakhnini, H. H. Fidder, S. Bar-Meir, B. Avidan
Journal: Endoscopy (2004)

Background and Study Aims: Percutaneous endoscopic gastrostomy (PEG) is a method used for feeding patients who are unable to eat. High early mortality rates among hospitalized patients have been reported. The aim of this study was to shed light on the risk factors for early mortality after PEG tube insertion. Patients and Methods: Outpatients from nursing homes and hospitalized patients who underwent PEG between July 1995 and July 2001 were compared. Survival analysis was used to assess mortality after PEG. In a logistic regression analysis, mortality within 30 days among hospitalized patients was chosen as the outcome variable and the predictor variables were demographic characteristics, co-morbid conditions, and indication for PEG. Results: A total of 502 PEG tubes were inserted in 419 hospitalized and 83 nursing-home patients. The prevalence of co-morbid conditions was similar in the two groups. Both the 30- and 60-day mortality rates were around six times higher in the hospitalized patient group than in the nursing-home patient group (30-day mortality rate 8 % vs. 1.2 %, P = 0.034; 60-day mortality rate 12 % vs. 2.4 %, P = 0.016). Risk factors for 30-day mortality among hospitalized patients were: serum albumin < 3 g/dl (odds ratio 2.82, 95 % CI 1.34 - 5.96), chronic obstructive pulmonary disease (odds ratio 2.79, 95 % CI 1.26 - 6.14), and diabetes mellitus (odds ratio 2.44, 95 % CI 1.20 - 4.97). Conclusions: Compared with nursing-home patients, hospitalized patients are at higher risk for early mortality after PEG. The presence of diabetes, chronic obstructive pulmonary disease, and a low serum albumin level each increase the 30-day mortality risk among hospitalized patients threefold.
The Relationship of Hand Abnormalities to Diabetes and Diabetic Retinopathy
Authors: P M Lawson, F Maneschi, E M Kohner
Journal: Diabetes Care (1983)

The hands of 299 diabetic patients with and 161 without retinopathy were examined for abnormalities. Almost all abnormalities were finger joint contractures resulting in limited joint mobility (LJM) and/or Dupuytren's contractures (DC). Both LJM and DC occurred not only in insulin-dependent diabetes (IDDM) but also in non-insulin-dependent diabetes (NIDDM). In retinopathy patients LJM and DC occurred in 48% and 36% of patients, respectively, compared with 24% and 16% in those without retinopathy. These differences were statistically significant (P less than 0.001). The higher prevalence of LJM in the retinopathy group affected mainly those with severe retinopathy, there being no difference between background and nonretinopathy patients. DC was less clearly related to severe retinopathy. LJM was more severe in those with than without retinopathy. LJM and DC were also related to age and duration of known diabetes. Subgroups matched for age and duration of known diabetes showed that the main relationship of hand abnormalities was to retinopathy in IDDM, but more to age and duration of known diabetes in NIDDM.
Hemorrhage into the gallbladder caused by pseudoaneurysm of the cystic artery
Authors: J. Pérez-Castrillón, M. Mendo, H. Calero
Journal: Endoscopy (2006)

A 77-year-old woman was admitted to hospital with cholecystitis. After 8 days of antibiotic treatment she developed hypotension, weakness, and anemia. Abdominal computed tomography showed a tense gallbladder containing blood and a round nodule which enhanced after administration of contrast material (Figure [1]). Doppler ultrasonography showed a nodule with arterial flow and a “ying yang” pattern (Figure [2]), and selective angiography revealed an cystic artery pseudoaneurysm (Figure [3]). Metallic coils were used as embolization material and full occlusion of the aneurysmal sac was achieved.
Proving Citizenship Difficult
Authors: Mike Mitka
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal