tbuckley/cabot-search huggingface dataset:
&lt;emph type="ital"&gt;Carolina Parrot&lt;/emph&gt; (&lt;emph type="ital"&gt;The Birds of America,&lt;/emph&gt; Plate 26)
Authors: Thomas B. Cole
Journal: JAMA (2010)

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Utah State Medical Society.
Authors: J. N. Harrison
Journal: JAMA (1895)

Salt Lake City, Utah, June 18,1895. <h3>To the Editor:</h3> —In February of the present year, a Utah State Medical Society was organized, its members comprising almost all of the best known physicians in the Territory. The Code of Ethics of theAmerican Medical Associationwas adopted. The first annual meeting will be held Oct. 1 and 2, 1895. The following is a list of officers elected: President, F. S. Bascom, M.D.; First Vice-President, Walter R. Pike, M.D.; Second Vice-President, G. M. Perkins, M.D.; Secretary, J. N. Harrison, M.D.; Treasurer, G. M. Wilson, M.D.
Alterations in 2-3 Diphosphoglycerate and O <sub>2</sub> Hemoglobin Affinity in Patients Undergoing Open-Heart Surgery
Authors: JOSEPH M. BORDIUK, PATRICK J. MCKENNA, STANLEY GIANNELLI, STEPHEN M. AYRES
Journal: Circulation (1971)

Alterations in red blood cell (RBC) 2-3 diphosphoglycerate (2-3 DPG) and hemoglobin affinity for oxygen were studied in 14 patients undergoing heart-lung bypass. RBC 2-3 DPG decreased with institution of bypass and continued to decrease during bypass. The day following heart-lung bypass RBC 2-3 DPG levels returned to normal, but were lower than preoperative control values. In vitro studies demonstrated that a portion of the RBC 2-3 DPG loss is due to circulation of blood through the oxygenator itself. Other factors appear to be involved. Hemoglobin affinity for oxygen increased during heart-lung bypass in most patients It was found that the increased affinity was less than would be expected relative to the demonstrated RBC 2-3 DPG decrease, and that a progressive decrease in RBC pH partially corrected the alteration in O 2 affinity. Our data suggest that other factors are involved in the demonstrated alteration in hemoglobin affinity for O 2 , and these factors are discussed.
Rotavirus Vaccination and Intussusception — Act Two
Authors: Harry B. Greenberg
Journal: New England Journal of Medicine (2011)

The development of vaccines has been a triumph of modern medicine.1 In addition to the eradication of smallpox and the near-eradication of polio, the past 30 years has seen an impressive decline in many vaccine-preventable diseases, including measles, hepatitis B virus, serious pneumococcal infection, hemophilus influenza, and, recently, rotavirus. Vaccination has been an enormously powerful force for health improvement because of the large societal benefits provided with remarkably small risks. However, some have expressed worry that current vaccines are dangerous and represent a considerable threat to the health of the recipients.2 These concerns often do not include an analysis of . . .
Lung cancer susceptibility locus at 5p15.33
Authors: James D McKay, Rayjean J Hung, Valerie Gaborieau, Paolo Boffetta, Amelie Chabrier, Graham Byrnes, David Zaridze, Anush Mukeria, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Dana Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, John McLaughlin, Frances Shepherd, Alexandre Montpetit, Steven Narod, Hans E Krokan, Frank Skorpen, Maiken Bratt Elvestad, Lars Vatten, Inger Njølstad, Tomas Axelsson, Chu Chen, Gary Goodman, Matt Barnett, Melissa M Loomis, Jan Lubiñski, Joanna Matyjasik, Marcin Lener, Dorota Oszutowska, John Field, Triantafillos Liloglou, George Xinarianos, Adrian Cassidy, Diana Zelenika, Anne Boland, Marc Delepine, Mario Foglio, Doris Lechner, Fumihiko Matsuda, Helene Blanche, Ivo Gut, Simon Heath, Mark Lathrop, Paul Brennan
Journal: Nature Genetics (2008)
Heroin and Pethidine During Labour
Authors: J. Ross
Journal: BMJ (1947)

thermostatic control is fitted.Presumably a baby suffering from artificial heat-stroke would have the symptoms of dehydration fever, and the cause of death would be " prematurity."Too great a weight of blankets on the infant's cot may possibly be a cause of fatigue of the respiratory muscles-and death.The zealous, harassed, but inexperienced mother should be warned of this risk.Is the danger fully realized ?Though, as already stated, I have not yet seen in print any expression of approval of my suggestion to have this matter thoroughly and conscientiously investigated, obstetric specialists in centres in this country and as far afield as Australia have expressed their complete agreement with my remarks.The
Mothers and children in hospital.
Authors: J. Pead
Journal: BMJ (1968)

approach, his curve was 90'.Thus, three spines out of a group of 60 with a similar condition were distorted by a hiatus hernia box, and all three are among the small pro- portion (7 out of 60) who failed to resolve without demonstrable cause within 18 months.It is possible that prolonged " sitting " in the box acted against resolution of the curve.Whilst treating hiatus hernia in an infant one has no attractive alternative to using the box, but its use in normal children, which is becoming increasingly popular, should be watched.-Iam, etc.,
Moderate- vs High-Dose Methadone in the Treatment of Opioid Dependence
Authors: Eric C. Strain, George E. Bigelow, Ira A. Liebson, Maxine L. Stitzer
Journal: JAMA (1999)

Context Methadone hydrochloride treatment is the most common pharmacological intervention for opioid dependence, and recent interest has focused on expanding methadone treatment availability beyond traditional specially licensed clinics.However, despite recommendations regarding effective dosing of methadone, controlled clinical trials of higher-dose methadone have not been conducted.Objective To compare the relative clinical efficacy of moderate-vs high-dose methadone in the treatment of opioid dependence.
Letter: Was it a drug? Forceval protein.
Authors: A Lewis
Journal: BMJ (1974)

a dosage of up to 400 mg daily.This drug is used for its muscle-relaxing properties in tetanus, but it was first introduced into medical practice as a vermifuge.The worm absorbs the drug but, unlike its host, is unable to m,etabolize or excrete it.The anthelmintic property may be related to an anticholinesterase action which upsets the neuromuscular apparatus of the worm or alternatively to an effect on redox systems.These mechanisms might be expected to paralyse the worm, but our experience is that they retain their motility on expulsion in cases of tetanus.It would be helpful if further light could be thrown on this problem.-Weare, etc.,
A Simulation Study of the Reliability of Recombination Detection Methods
Authors: Carsten Wiuf, Thomas Christensen, Jotun Hein
Journal: Molecular Biology and Evolution (2001)

There exist many methods to detect recombination or mosaic structure in a sample of DNA sequences. But how reliable are they? Four methods were investigated with respect to their power to detect recombination in simulated samples with different amounts of recombination and mutation. In addition, we investigated the impact of the shape of the underlying genealogy on their performances. We found that the methods detected far fewer recombinations than were theoretically possible and that methods based on the principle of incompatibility in general had more power than methods that did not make use of this principle explicitly. This seemed, in particular, to be the case for phylogenies generated under population expansion scenarios which result in long branches at the tips and small deep branches. In addition to the results obtained through simulations, a series of new theoretical results on recombination is presented.
Last-Resort Options for Palliative Sedation
Authors: Timothy E. Quill
Journal: Annals of Internal Medicine (2009)

Despite receiving state-of-the-art palliative care, some patients still experience severe suffering toward the end of life. Palliative sedation is a potential way to respond to such suffering, but access is uneven and unpredictable, in part because of confusion about different kinds of sedation. Proportionate palliative sedation (PPS) uses the minimum amount of sedation necessary to relieve refractory physical symptoms at the very end of life. To relieve suffering may require progressive increases in sedation, sometimes to the point of unconsciousness, but consciousness is maintained if possible. Palliative sedation with the intended end point of unconsciousness (PSU) is a more controversial practice that may be considered for much fewer refractory cases. There is more ethical consensus about PPS than PSU. In this article, the authors explore the clinical, ethical, and legal issues associated with these practices. They recommend that palliative care and hospice programs develop clear policies about PPS and PSU, including mechanisms for training and ensuring competency for clinicians, and approaching situations where individuals or institutions may conscientiously object.
Thyroid Hormone Inactivation in Gastrointestinal Stromal Tumors
Authors: Michelle A. Maynard, Adrian Marino-Enriquez, Jonathan A. Fletcher, David M. Dorfman, Chandrajit P. Raut, Leila Yassa, Cuicui Guo, Yuexiang Wang, Clara Dorfman, Henry A. Feldman, Mary C. Frates, Huaidong Song, Rebecca H. Jugo, Takahiro Taguchi, Jerome M. Hershman, P. Reed Larsen, Stephen A. Huang
Journal: New England Journal of Medicine (2014)

Gastrointestinal stromal tumors (GISTs) are resistant to traditional chemotherapy but are responsive to the tyrosine kinase inhibitors imatinib and sunitinib. The use of these agents has improved the outcome for patients but is associated with adverse effects, including hypothyroidism. Multiple mechanisms of this effect have been proposed, including decreased iodine organification and glandular capillary regression. Here we report the finding of consumptive hypothyroidism caused by marked overexpression of the thyroid hormone-inactivating enzyme type 3 iodothyronine deiodinase (D3) within the tumor. Affected patients warrant increased monitoring and may require supernormal thyroid hormone supplementation.
Working with adult survivors of child sexual abuse.
Authors: S Bewley
Journal: BMJ (1993)

been carried out for phenylketonuria since the mid-1970s and testing for hypothyroidism since the mid-'80s.Our recent data on new mothers' knowledge of these tests suggests that ignomce is widespread.As part of the Cambridge prenatal screening study, 1387 women from nine hospitals in four regions completed a postal questionnaire six weeks after giving birth.2All but eight women knew where the test had been done (1209 at home and 163 in hospital, with more primiparous women tested in hospital).Most women (951) said that the test had been fully explained and 222 "knew about it already."The extent to which women thought that they were informed, however, was not reflected in the answers to a question about which disorders this blood sample was tested for (table ).Mothers' responses to question "Which of the following was your baby testedfor?" Don't YesNo knowCystic fibrosis (n=1232)
The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways
Authors: Daniela de Totero, Raffaella Meazza, Matteo Capaia, Marina Fabbi, Bruno Azzarone, Enrico Balleari, Marco Gobbi, Giovanna Cutrona, Manlio Ferrarini, Silvano Ferrini
Journal: Blood (2007)
Maternity blues and major endocrine changes: Cardiff puerperal mood and hormone study II
Authors: B Harris, L Lovett, R G Newcombe, G F Read, R Walker, D Riad-Fahmy
Journal: BMJ (1994)

<h3>Abstract</h3> <b>Objectives</b>: To define relation between mood and concentrations of progesterone and cortisol during perinatal period to test hypothesis that rapid physiological withdrawal of steroid hormones after delivery is associated with depression. <b>Design</b>: Prospective study of primiparous women from two weeks before expected date of delivery to 35 days postpartum. <b>Setting</b>: Antenatal clinic in university hospital, obstetric inpatient unit, patients9 homes. <b>Subjects</b>: 120 of 156 primiparous women interviewed. Remainder excluded because of major marital, socioeconomic, or medical problems or because caesarean section required. <b>Main outcome measures</b>: Concentrations of progesterone and cortisol in saliva samples; women9s moods assessed by various scores for depression. Results - Changes in salivary progesterone and cortisol concentrations were similar to those already characterised for plasma. Peak mean score for maternity blues (5.3 on Stein scale) was on day five postpartum (P&lt;0.02 compared with mean scores on other postpartum days). High postpartum scores for maternity blues were associated with high antenatal progesterone concentrations on day before delivery (P&lt;0.05), with high rate of rise of antenatal progesterone concentrations (P&lt;0.05), with decreasing progesterone concentrations from day of delivery to day of peak blues score (P&gt;=0.01), and with low progesterone concentrations on day of peak blues score (P&lt;0.01). Seventy eight women were designated as having maternity blues (peak score &gt;=8 on Stein scale) while 39 had no blues. Women with blues had significantly higher antenatal progesterone concentrations and lower postnatal concentrations than women without blues (geometric mean progesterone concentrations: one day before delivery 3860 pmol/l v 3210 pmol/l respectively, P=0.03; ten days postpartum 88 pmol/l v 114 pmol/l, P=0.048). Cortisol concentrations were not significantly associated with mood. <b>Conclusion</b>: Maternal mood in the days immediately after delivery is related to withdrawal of naturally occurring progesterone.
Myositis and Myalgia: Dysphagia and Phlegmasia Dolens
Authors: T. Inman
Journal: BMJ (1860)

earthy.The blotching on the forehead is scarcely distinguish- able.The tumours are as before.On examination, no sores are discovered on the pudenda; the patient says they have dis- appeared since her admission into the Hospital.May 10th.The tumours are apparently diminished in size.The cutaneous eruption is certainly much less perceptible.The throat is better; the tonsils, however, are still enlarged.May 12th to 20th.The patient's health has been somewbat disturbed.The bowels are relaxed; the appetite is bad; and on 11 August
Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenström’s macroglobulinemia and related lymphoid neoplasms
Authors: Marzia Varettoni, Luca Arcaini, Silvia Zibellini, Emanuela Boveri, Sara Rattotti, Roberta Riboni, Alessandro Corso, Ester Orlandi, Maurizio Bonfichi, Manuel Gotti, Cristiana Pascutto, Silvia Mangiacavalli, Giorgio Croci, Valeria Fiaccadori, Lucia Morello, Maria Luisa Guerrera, Marco Paulli, Mario Cazzola
Journal: Blood (2013)
Down-regulation of genes related to the adrenergic system may contribute to splanchnic vasodilation in rat portal hypertension
Authors: Mar Coll, Joan Genescà, Imma Raurell, Aina Rodríguez-Vilarrupla, Marc Mejías, Teresa Otero, Marc Oria, Rafael Esteban, Jaime Guardia, Jaime Bosch, María Martell
Journal: Journal of Hepatology (2008)
Evidence That Growth Failure From Maternal Deprivation Is Secondary to Undereating
Authors: Charles F. Whitten
Journal: JAMA (1969)

This study was instituted to test the validity of the assumption that the growth failure in the "maternal deprivation syndrome" is due to psychological factors. Eleven of 13 maternally deprived infants gained weight at an accelerated rate when fed adequately while living in a hospital environment which simulated their home environment. Two failed to gain, but their intakes were low. In addition, seven of seven deprived infants gained rapidly in their own homes when fed an adequate diet by the mother (in the presence of our observer) during a period when it was unlikely that overall maternal handling improved. The data suggest that maternally deprived infants are underweight because of undereating which is secondary to not being offered adequate food or not accepting it, and not because of some psychologically induced defect in absorption or metabolism.
Role of hydrostatic and oncotic pressures in renal sodium reabsorption.
Authors: F G Knox, J I Mertz, J C Burnett, A Haramati
Journal: Circulation Research (1983)

Physical factors, and renal interstitial hydrostatic pressure in particular, have an important effect on sodium excretion by the kidney. Changes in hydrostatic and oncotic pressures in the peritubular microcirculation may have effects on proximal tubule reabsorption under some, but not all, circumstances. In regard to control of sodium excretion, the loop of Henle may be a particularly important segment which is sensitive to transepithelial hydrostatic pressure changes. There is little evidence to support an effect of physical factors on sodium reabsorption by the distal tubule. The collecting tubule may be another pressure-sensitive site; however, changes in sodium reabsorption by deep nephrons in the kidney may account for changes that have been attributed to the collecting duct. Changes in intrarenal pressure may be an important link in the regulation of sodium excretion, particularly in pathological circumstances, such as the exaggerated natriuresis of hypertension and the sodium retention seen in congestive heart failure.
Use of parenteral iron products and serious anaphylactic‐type reactions
Authors: Diane K. Wysowski, Lynette Swartz, B. Vicky Borders‐Hemphill, Margie R. Goulding, Catherine Dormitzer
Journal: American Journal of Hematology (2010)

Controversy exists about the safety of the parenteral iron dextran products, Dexferrum and INFeD, which have been associated with rare, serious anaphylactic-type reactions. In the United States, their product labels carry boxed warnings of this adverse event; some have called for the withdrawal from marketing of the higher molecular weight Dexferrum. Between 2002 and 2007, sales of Dexferrum, INFeD, and iron gluconate Ferrlecit declined 32.5%, 21%, and 4.8%, respectively, while sales of iron sucrose Venofer increased 160%. Voluntary reports submitted to the Food and Drug Administration show anaphylactic reactions and symptoms for the four parenteral iron products. Because of underreporting, possible differential reporting, absence of iron dextran brand names, and incomplete use (denominator) data, incidence rates and relative risk estimates cannot be calculated. U.S. death certificate data show that for most years from 1979 through 2006, no more than 3 deaths per year were coded to "adverse events in therapeutic use of iron preparations;" brand names were not consistently recorded. Emergency department data show small numbers of visits for treatment of allergic reactions with intravenous iron preparations. The data presented herein show that allergic reactions are possible with all four parenteral iron products, and it is difficult to determine which product has the largest risk based on sales data, voluntarily submitted adverse event reports, death certificates, ED visits, and observational studies performed to date. To help differentiate risk among the parenteral iron products, the brand name of the product always should be provided on medical records, death certificates, and adverse drug reaction reports.
Postviral fatigue syndrome: Author's reply
Authors: P O Behan
Journal: BMJ (1992)

The authors state that all the patients with the postviral fatigue syndrome had characteristic mitochondrial changes, and some had RNA enteroviral sequences, but as the necessary investigations were not applied to the depressed patients or controls it is not possible to tell whether these findings did in fact distinguish the group with the syndrome.Another issue that concerns us is that the authors fail to refer to the considerable body of work suggesting that release of prolactin mediated by 5-hydroxytryptamine is suppressed in depressed patients"4 and that this response is enhanced by antidepressant treatments, including electrocon- vulsive therapy.5There is a non-significant trend in their study for the depressed patients to have a smaller rise in prolactin secretion than controls, with the patients with the postviral fatigue syndrome having a significantly higher response than that of both the other groups.The finding that the prolactin response seems to be changed in opposite directions in the postviral fatigue
Tragic Events of April 1996
Authors: Kenneth J. Simcic
Journal: Annals of Internal Medicine (2001)

Letters6 March 2001Tragic Events of April 1996Kenneth J. Simcic, MDKenneth J. Simcic, MDBrooke Army Medical Center; Ft. Sam Houston, TX 78234-6200 (Simcic)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-5-200103060-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read Coulehan's perspective on Australia's 1996 Port Arthur tragedy with great interest (1). Why is the Australian people's reaction to random mass murder so much different from that of Americans? Why do Australians still feel “connected” to the victims of the Port Arthur tragedy, whereas in the United States, repeated school killings “cause only brief outbursts of dismay and very timid national reactions” (1)? One Australian quoted in the article states that Americans are “so inured to violence that they don't care.” If this accusation is true, why are Australians so different in this regard?I ...Reference1. Coulehan J. The tragic events of April 1996. Ann Intern Med. 2000;132:911-3. [PMID: 0010836919] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Brooke Army Medical Center; Ft. Sam Houston, TX 78234-6200 (Simcic) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Tragic Events of April 1996 Jack Coulehan Tragic Events of April 1996 Robert Starkenburg Tragic Events of April 1996 Katherine E. Tiller Tragic Events of April 1996 Harry J. Driedger Tragic Events of April 1996 Stephen Sandroni Tragic Events of April 1996 Jack Coulehan Metrics 6 March 2001Volume 134, Issue 5Page: 424KeywordsAdolescentsChildrenGamesHomicidePerception ePublished: 6 March 2001 Issue Published: 6 March 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...