Naloxone and Ethanol Intoxication
Authors: J.M. GUERIN
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 December 1982Naloxone and Ethanol IntoxicationJ.M. GUERIN, G. FRIEDBERGJ.M. GUERINSearch for more papers by this author, G. FRIEDBERGSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-6-932_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A recent article in your journal emphasizes the interest in naloxone for ethanol intoxication (1).For 2 years we have been systematically using naloxone for patients with ethanol intoxication in a prospective study (2). Twelve patients with ethanol-induced coma have been seen at the Lariboisière Hospital in Paris. In all cases the patient had flaccid limbs, pupil constriction, and alveolar hypoventilation, but no evidence of hypoglycemia. These patients received intravenous injections of naloxone, 0.4 to 0.6 mg, and all regained normal consciousness within several minutes. Naloxone was also used in 23 patients who had a combined alcohol...References1. LYON L and ANTONY J. Reversal of alcoholic coma by naloxone. Ann Intern Med. 1982;96:464-5. LinkGoogle Scholar2. GUERIN J, GIESZ J, and LAMOTTE M. Traitement du coma éthylique par la naloxone. Nouv Presse Med. 1981;23:1942. Google Scholar3. JEFFERYS D, FLANAGAN R, and VOLANS G. Reversal of ethanol induced coma with naloxone. Lancet. 1980;1:308-9. CrossrefMedlineGoogle Scholar4. MATTILA M, NUOTTO E, and SEPPALA T. Naloxone is not an effective antagonist of ethanol. Lancet. 1981;1:775-6. CrossrefMedlineGoogle Scholar5. JEFFCOATE W, CULLEN M, HERBERT M, HASTINGS A, and WALDER C. Prevention of effects of alcohol intoxication by naloxone. Lancet. 1979;2:1157-9. CrossrefMedlineGoogle Scholar6. KIMBALL C, HUANG S, TOGET C, and HOUCK J. Plasma ethanol, endorphin and glucose experiment. Lancet. 1980;2:418-9. CrossrefMedlineGoogle Scholar7. NABER D, SOBLE M, and PICKAR D. Ethanol increases opioid activity in plasma of normal volunteers. Pharmacopsychiatry. 1981;14:160-1. CrossrefGoogle Scholar8. CATLEY D, JORDAN C, FRITH C, LEHANE J, RHODES A, and JONES J. Alcohol induced discoordination is not reversed by naloxone. Psychopharmacology. 1981;75:65-8. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J.M. GUERIN; G. FRIEDBERGAffiliations: Centre de Réanimation Hôpital Lariboisière 75010 Paris France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPharmacological AntidotesIntravenous saline has no effect on blood ethanol clearanceA comprehensive review of naloxone for the emergency physicianGastric emptying in the acutely inebriated patientMorphine-ethanol interaction on body temperatureAcute Ethanol Poisoning and the Ethanol Withdrawal SyndromeEffect of ethanol on the binding of conformationally rigid and labile ligands of opioid receptors to rat brain membranesClinical use of opioid antagonistsEthanol’s Action on Brain BiochemistryNaloxonbehandlung der Alkoholvergiftung — Aspekte zur biologischen Theorie des AlkoholismusNaloxone in shock and toxic comaNaloxone: New therapeutic rolesEndogenous opiates: 1982NaloxoneNaloxone in Ethanol IntoxicationA.A.-B. BADAWY, M.D., M. EVANS, M.D. 1 December 1982Volume 97, Issue 6Page: 932-932KeywordsAlcoholsComaConsciousnessEthanolHypoglycemiaIntoxicationIntravenous injectionsProspective studies ePublished: 1 December 2008 Issue Published: 1 December 1982 PDF downloadLoading ...