tbuckley/cabot-search huggingface dataset:
Introduction to the Ernst August Dölle Symposium on Nonpublishable Psychosomatic Papers
Authors: Adolf-Ernst Meyer
Journal: Psychotherapy and Psychosomatics (1984)

Introductions| February 17 2010 Introduction to the Ernst August Dölle Symposium on Nonpublishable Psychosomatic Papers Subject Area: Psychiatry and Psychology Adolf-Ernst Meyer Adolf-Ernst Meyer Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1984) 42 (1-4): 105. https://doi.org/10.1159/000287831 Article history Published Online: February 17 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Adolf-Ernst Meyer; Introduction to the Ernst August Dölle Symposium on Nonpublishable Psychosomatic Papers. Psychother Psychosom 31 December 1984; 42 (1-4): 105. https://doi.org/10.1159/000287831 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1984Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Cholangioscopic Characterization of Dominant Bile Duct Stenoses in Patients with Primary Sclerosing Cholangitis
Authors: J. Tischendorf, M. Krüger, C. Trautwein, N. Duckstein, A. Schneider, M. Manns, P. Meier
Journal: Endoscopy (2006)

Primary sclerosing cholangitis (PSC) is associated with the development of cholangiocarcinoma in up to 10 % of patients. Cholangiography or endoscopic tissue sampling does not reliably distinguish between cholangiocarcinoma and a benign dominant bile duct stenosis. The aim of the present study was to assess the value of cholangioscopy for distinguishing between benign and malignant dominant stenoses in PSC patients.Fifty-three PSC patients with dominant bile duct stenoses were prospectively studied. Transpapillary cholangioscopy and endoscopic tissue sampling were carried out in addition to endoscopic retrograde cholangiography (ERC). The cholangiography and cholangioscopic findings were classified as malignant or benign by the investigators. A final diagnosis of malignant stenosis was based on positive histology and/or cytology, whereas a benign condition was assumed in cases of negative tissue sampling and uneventful extended clinical follow-up.Twelve PSC patients (23 %) had dominant bile duct stenoses caused by cholangiocarcinoma, whereas 41 of the 53 patients (77 %) had benign dominant bile duct stenoses. Cholangioscopy was significantly superior to ERC for detecting malignancy in terms of its sensitivity (92 % vs. 66 %; P = 0.25), specificity (93 % vs. 51 %; P < 0.001), accuracy (93 % vs. 55 %; P < 0.001), positive predictive value (79 % vs. 29 %; P < 0.001), and negative predictive value (97 % vs. 84 %; P < 0.001). Transpapillary cholangioscopy is more sensitive and specific for characterizing malignant bile duct stenosis in comparison with endoscopic brush cytology.Transpapillary cholangioscopy significantly increases the ability to distinguish between malignant and benign dominant bile duct stenoses in patients with PSC.
Implications of prognostic pessimism in patients with chronic obstructive pulmonary disease (COPD) or asthma admitted to intensive care in the UK within the COPD and asthma outcome study (CAOS): multicentre observational cohort study
Authors: Martin J Wildman, Colin Sanderson, Jayne Groves, Barnaby C Reeves, Jon Ayres, David Harrison, Duncan Young, Kathy Rowan
Journal: BMJ (2007)

<b>Objective</b> To determine whether clinicians9 prognoses in patients with severe acute exacerbations of obstructive lung disease admitted to intensive care match observed outcomes in terms of survival. <b>Design</b> Prospective cohort study. <b>Setting</b> 92 intensive care units and three respiratory high dependency units in the United Kingdom. <b>Participants</b> 832 patients aged 45 years and older with breathlessness, respiratory failure, or change in mental status because of an exacerbation of COPD, asthma, or a combination of the two. <b>Main outcome measures</b> Outcome predicted by clinicians. Observed survival at 180 days. <b>Results</b> 517 patients (62%) survived to 180 days. Clinicians9 prognoses were pessimistic, with a mean predicted survival of 49% at 180 days. For the fifth of patients with the poorest prognosis according to the clinician, the predicted survival rate was 10% and the actual rate was 40%. Information from a database covering 74% of intensive care units in the UK suggested no material difference between units that participated and those that did not. Patients recruited were similar to those not recruited in the same units. <b>Conclusions</b> Because decisions on whether to admit patients with COPD or asthma to intensive care for intubation depend on clinicians9 prognoses, some patients who might otherwise survive are probably being denied admission because of unwarranted prognostic pessimism.
Suppression of F-18 Fluorodeoxyglucose Uptake in Benign Uterine Leiomyomas With Danazol
Authors: Madhavi Tripathi, Madhur Srivastava, Gunjun Garg, Abhinav Jaimini, Namita Singh, Maria D. Souza, Prabhjot Kaur, Rajnish Sharma, Anupam Mandal
Journal: Clinical Nuclear Medicine (2009)

A 40-year premenopausal woman was referred by her treating oncologist for F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to rule out disease recurrence or metastasis. She had completed therapy for Hodgkin lymphoma (Stage IIA) 1 year earlier. Post-therapy gallium-67 study showed no evidence of residual disease and the patient was on regular follow-up. The only abnormality detected on the FDG-PET/CT study was a focus of abnormal FDG accumulation in the pelvis, suprapubically. Fused PET-CT localized the uptake to the uterine myometrium in the fundal region posteriorly corresponding to mild inhomogeneity in attenuation with a bulky uterus on CT. MRI of the pelvis confirmed the presence of a uterine leiomyoma in the fundal region. The patient was put on danazol (200 mg twice daily for 14 days) and a repeat PET-CT of the pelvis was done after 14 days, which revealed complete disappearance of FDG uptake in the leiomyoma. This proved that F-18 FDG uptake in the leiomyoma was probably related to its vascularity.
Relative Scarcity of Asthma and Atopy among Rural Adolescents Raised on a Farm
Authors: PIERRE ERNST, YVON CORMIER
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

We determined the prevalence of markers of atopy and asthma among 1,199 rural secondary school students ages 12 to 19 yr. Subjects identified as having been raised on a farm and half as many subjects without regular exposure to a farming environment from the same school class completed a respiratory symptom questionnaire and underwent allergy skin tests and a methacholine bronchoprovocation test. Current wheeze, airways hyperresponsiveness (AHR), and skin test positivity to inhaled allergens were all significantly less common among adolescents raised on the farm and these differences were especially pronounced in girls. After adjusting for gender and current smoking, the odds ratios for being raised on a farm were: 0.70 (95% CI 0.52 to 0.95) for current wheeze; 0.59 (95% CI 0.37 to 0.95) for asthma, defined as the concomitant occurrence of wheeze and AHR; and 0.58 (95% CI 0.46 to 0.75) for atopy defined as a positive reaction to any one of 24 common inhaled allergens. These associations were also not significantly altered by adjusting for the difference in the number of siblings.
Basement membrane components and galactosylhydroxylysyl glucosyltransferase in suction blisters of human skin
Authors: AARNE OIKARINEN, EEVA-RIITTA SAVOLAINEN, KARL TRYGGVASON, JEAN MICHEL FOIDART, URPO KIISTALA
Journal: British Journal of Dermatology (1982)

Basement membrane components and collagen biosynthesis were studied in suction blisters in human skin. The basement membrane components were characterized by immunofluorescence using specific antibodies to type IV collagen, laminin and fibronectin, and collagen biosynthesis was studied by assaying galactosylhydroxylysyl glucosyltransferase. In suction blisters, the separation of epidermis and dermis occurred above the lamina lucida, indicating that the basement membrane, composed of lamina lucida and lamina dcnsa, forms a mechanically strong entity. During the regeneration phase of blisters, type IV collagen and laminin were not observed in the old epidermal blister roof. This indicates that keratinocytes when separated from the underlying basement membrane or connective tissue do not synthesize laminin or type IV collagen. GalactosylhydroxylysyJ glucosyltransferase activity could be demonstrated in blister fluid and was about the same as in serum when expressed on the basis of protein in fresh blisters. It increased by 2–3 fold during the repair of blisters, indicating that there was local production of this enzyme. Further studies revealed that pure epidermis contained galactosylhydroxylysyl glucosyltransferase and hydroxyproline and this suggests that epidermis may synthesize some collagen type which, according to these studies, is not type IV (basement membrane) collagen.
Treatment of Myxedema-Associated Cardiogenic Shock
Authors: Chris S. Mantzoros
Journal: Annals of Internal Medicine (1993)

Letters15 July 1993Treatment of Myxedema-Associated Cardiogenic ShockChris S. Mantzoros, MD and Jyotsna Ravi, MDChris S. Mantzoros, MDSearch for more papers by this author and Jyotsna Ravi, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-2-199307150-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The interesting report of a myxedema-associated cardiogenic shock treated with intravenous triiodothyronine [1] raised several questions.Intravenous triiodothyronine rapidly normalizes both myocardial performance and metabolic abnormalities [2]; on the other hand, although most thyroxine-treated patients may respond clinically within 48 hours [3], it may take up to 1 week before beneficial effects are seen [1, 2]. Finally, a low-dose (25 g) triiodothyronine regimen for 1 week is equivalent to an equipotent (100 g) dose of thyroxine in reversing cardiac and metabolic abnormalities, although such a regimen is significantly less effective in lowering serum thyroid-stimulating hormone (TSH) levels ...References1. Mackerrow SD, Osborn LA, Levy H, Eaton RP, Economou P. Myxedema-associated cardiogenic shock treated with intravenous triiodothyronine. Ann Intern Med. 1992; 117:1014-5. Google Scholar2. Ladenson PW, Goldenheim PD, Ridgway EC. Rapid pituitary and peripheral tissue responses to intravenous l-triiodothyronine in hypothyroidism. J Clin Endocrinol Metab. 1983; 56:1252-9. Google Scholar3. Fenichel P, Zartariana M, Frimaud D, Brucker F, Morand Ph, Harter M. Le coma myxoedemateux. Reevaluation prognostique et therapeutique. Presse Med. 1988; 17:1345-8. Google Scholar4. Klein I, Ojamaa K. Cardiovascular manifestations of endocrine disease. J Clin Endocrinol Metab. 1992; 75:339-42. Google Scholar5. Lemar HJ, West SG, Garrett CR, Hofeldt FD. Covert hypothyroidism presenting as a cardiovascular event. Am J Med. 1991; 91:549-52. Google Scholar Author, Article, and Disclosure InformationAuthors: Chris S. Mantzoros, MD; Jyotsna Ravi, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 July 1993Volume 119, Issue 2Page: 168-169KeywordsCardiovascular therapyHypothyroidismLongitudinal studiesPatientsResearch laboratoriesShockStable coronary artery diseaseThyroid-stimulating hormoneThyroxineTriiodothyronine ePublished: 15 August 2000 Issue Published: 15 July 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
GONOCOCCUS INFECTION OF THE MUCOUS MEMBRANE OF THE ORAL CAVITY
Authors: John Mills Mayhew
Journal: JAMA (1918)

History.  —N., a student, aged 19, had always been in good health. He denied venereal disease or recent exposure of any kind. Jan. 2, 1918, the day before his departure from his home at Sheridan, Wyo., to attend a college in Massachusetts, he visited a dentist to have his teeth cleaned. He reported that the dentist was so rough that his mouth bled in several places after the treatment. Within twenty-four hours he had a great deal of pain and a burning sensation in the buccal portion of the lips, and within forty-eight hours his throat was sore. Sixty hours after the treatment his lips were swollen and painful, and vesicles formed at the corners of the mouth. He could not swallow anything but the blandest of liquids, and even warm water hurt his throat severely. I saw him four days after the trouble began —five days from the time
Decrease in Plasma High-Density Lipoprotein Cholesterol Levels at Puberty in Boys With Delayed Adolescence
Authors: Rebecca T. Kirkland, Bruce S. Keenan, Jeffrey L. Probstfield, Wolfgang Patsch, Tsai Lien Lin, George W. Clayton, William Insull
Journal: JAMA (1987)

A three-phase study tested the hypothesis that the decrease in the high-density lipoprotein cholesterol (HDL-C) level observed in boys at puberty is related to an increase in the plasma testosterone concentration. In phase I, 57 boys aged 10 to 17 years were categorized into four pubertal stages based on clinical parameters and plasma testosterone levels. These four groups showed increasing plasma testosterone values and decreasing HDL-C levels. In phase II, 14 boys with delayed adolescence were treated with testosterone enanthate (100, 200, and 200 mg/mo, respectively, for three months). Plasma testosterone levels during therapy were in the adult male range. Levels of HDL-C decreased by a mean of 7.4 mg/dL (0.20 mmol/L) and 13.7 mg/dL (0.35 mmol/L), respectively, after the first two doses. In phase III, 13 boys with delayed adolescence demonstrated increasing plasma testosterone levels and decreasing HDL-C levels (-12.0 mg/dL [-0.30 mmol/L]) during spontaneous puberty. Levels of HDL-C and apolipoprotein A-1 were correlated during induced and spontaneous puberty. Testosterone should be considered a significant determinant (not necessarily directly causal) of plasma HDL-C levels during pubertal development.
JAK2 V617F mutational status predicts progression to large splenomegaly and leukemic transformation in primary myelofibrosis
Authors: Giovanni Barosi, Gaetano Bergamaschi, Monia Marchetti, Alessandro M. Vannucchi, Paola Guglielmelli, Elisabetta Antonioli, Margherita Massa, Vittorio Rosti, Rita Campanelli, Laura Villani, Gianluca Viarengo, Elisabetta Gattoni, Giancarla Gerli, Giorgina Specchia, Carmine Tinelli, Alessandro Rambaldi, Tiziano Barbui
Journal: Blood (2007)
Diagnosing diabetes using glycated haemoglobin A1c
Authors: W. Yang
Journal: BMJ (2010)

Could have several advantages over traditional diagnostic methods

Diabetes is one of the three most prevalent chronic diseases that pose serious threats to health. A recent study of 46 239 Chinese people aged 20 years or more indicated a prevalence of diabetes and prediabetes (blood glucose between normal and diabetic values) of 9.7% and 15.5%, respectively.1 These figures translate into a total of 92.4 million people in China with diabetes. In the linked study (doi:10.1136/bmj.c2249), Bao and colleagues assess the value of glycated haemoglobin A1c (HbA1c) in diagnosing diabetes and identify the optimal HbA1c cut-off value to be used in Chinese adults.2

Currently, fasting plasma glucose values and the oral glucose tolerance test are most commonly used for the screening and diagnosis of diabetes. However, both require a fast of at least eight hours, and the oral glucose tolerance test also requires …
Amodiaquine induced agranulocytosis: inhibition of colony growth in bone marrow by antimalarial agents.
Authors: E G Rhodes, J Ball, I M Franklin
Journal: BMJ (1986)

Bone marrow was cultured in vitro for colonies of granulocytes and macrophages five months after a patient had recovered from amodiaquine induced agranulocytosis. The addition of amodiaquine, chloroquine, and sulfadoxine to the culture was followed by a dose dependent inhibition of colony growth in the patient9s marrow but not in normal control bone marrow. Colony growth was, however, unaffected by proguanil, pyrimethamine, and quinine. These findings show that in vitro marrow culture may have important predictive value in some cases of drug induced agranulocytosis.
Community leg ulcer clinics: a comparative study in two health authorities
Authors: D. A Simon, L. Freak, A. Kinsella, J. Walsh, C. Lane, L. Groarke, C. McCollum
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objective</b>: To compare the outcome and cost of care for leg ulcers in community leg ulcer clinics in Stockport District Health Authority with Trafford District Health Authority as a control. <b>Design</b>: Detailed cost and efficacy studies conducted prospectively over a three month period in both districts both before and one year after the introduction of five leg ulcer clinics in Stockport. <b>Setting</b>: Two large district health authorities of broad socioeconomic mix and total population of 540 000. <b>Patients</b>: All patients receiving treatment for an active leg ulcer, irrespective of the profession or location of their carer. <b>Main outcome measures</b>: The proportion of ulcerated limbs completely healed within three months and total cost of leg ulcer care. <b>Results</b>: The introduction of community clinics in Stockport improved healing of leg ulcers from 66/252 (26%) in 1993 to 99/233 (42%) in 1994 (P&lt;0.001) compared with in Trafford, where 47/203 (23%) healed in 1993 and only 43/213 (20%) in 1994. This improved result in Stockport was achieved while the annual expenditure on care of leg ulcers was reduced from £409 991 to only £253 371. In the same year the cost of leg ulcer care in Trafford increased from £556 039 to £673 318. <b>Conclusion</b>: In the first year after the introduction of community clinics, before most patients in Stockport had access to these clinics, healing of leg ulcers was already improved whereas costs were reduced. <h3>Key messages</h3> The introduction of community leg ulcer clinics improved care and resulted in lower costs than the traditional approach that the clinics replaced Planned and coordinated programmes of care can reduce costs substantially while improving healing rates Community units and general practitioners should be encouraged to seek alternatives to the standard care for leg ulcers
People evaluated for chest pain in emergency departments have low future risk of myocardial infarction, study finds
Authors: S. Mayor
Journal: BMJ (2015)

People evaluated by emergency departments for chest pain are at very low risk of myocardial infarction in the short and longer term future, shows a US study1 that questions the common practice of performing stress testing in such patients.

Non-invasive cardiac imaging is commonly used to assess cardiac function and coronary artery disease in patients with chest pain, but no evidence has shown that this reduces the risk of future cardiac events when compared with a more conservative approach. Information is also limited on the advantages and disadvantages of the …
P275 An afferent reservoir enables the Nippy 1 to deliver any gas
Authors: R. Richards
Journal: Thorax (2011)

<h3></h3> Non-invasive ventilation with some gas mixtures, such as high flow oxygen or Heliox, can be problematic and/or require expensive equipment. The addition of a pressurised afferent reservoir to the Nippy 1 ventilator (B&amp;D Electromedical) was studied to see if this would overcome these problems. The remote trigger of the Nippy 1 is essential to this design. A CPAP circuit was used to give a gas flow of at least 30 l/m; a 30 cm H<sub>2</sub>O safety valve was incorporated. A 3 l afferent reservoir (bag in bottle design) was added via a t-tube (Abstract P275 figure 1). The inner flexible bag was directly open to the CPAP circuit. The rigid outer casing had two ports, the first connected to the output from the Nippy 1 and the second connected to and exhaust valve controlled by the Nippy 1. A standard Nippy 1 breathing circuit conveyed the gas to the patient. As the patient breaths in the Nippy 1 is triggered and closes the two exhaust valves. The reservoir is pressurised by the ventilator providing a positive inspiratory pressure. In expiration both valves open enabling the patient to breathe out and the reservoir to refill. Pressure measurements at the mask showed that the system has an intrinsic PEEP of approximately 2.5 cm H<sub>2</sub>O; the trigger on the Nippy 1 was changed to a relative design to compensate. The circuit can be adjusted to deliver inspiratory pressures of up to 30 cm H<sub>2</sub>O. The pressure performance was unaltered when using Heliox, oxygen or air. The addition of a CPAP valve to the patient exhaust port could also be employed to raise the PEEP pressures as required. The development of this circuit may enable any gas to be used within the HDU/CCU setting without needing expensive equipment.
A SIMPLE EXPEDIENT FOR NEUTRALIZATION OF ALKALINE WATER
Authors: Maurice N. Richter
Journal: JAMA (1924)

Polychrome stains give optimal results in solutions that are near neutrality. Alkaline solutions increase, and acid solutions decrease the intensity of the blue component of the stains. To obtain this neutrality, a number of expedients have been devised, depending mainly on the neutralization of the water, using appropriate indicators. Acid waters are frequently encountered, and their neutralization with weak solutions of alkalis, such as sodium or potassium carbonate, gives good results. For the correction of slightly alkaline distilled water, carbon dioxid will give satisfactory results. The simplest procedure is to utilize the carbon dioxid of the breath by blowing into the mouth of a bottle partly filled with the water to be corrected, and shaking well. If one uses a small (1 or 2 ounce) bottle, enough carbon dioxid will be absorbed, after blowing into the bottle three or four times, to neutralize most of the alkaline waters ordinarily encountered.