tbuckley/cabot-search huggingface dataset:
P200 A qualitative european survey of patients perceptions of current management of idiopathic pulmonary fibrosis
Authors: AM Russell, C Vancheri, M Maronati, C Giot
Journal: Thorax (2013)

<h3>Objectives</h3> Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic lung associated with significant mortality. There has been a marked increased interest in IPF and new emerging therapies have been shown to improve either the survival or quality of life for some people with IPF. This study aimed to explore patient’s perceptions of current therapy &amp; management of IPF, specifically pirfenidone as the first approved treatment. <h3>Methods</h3> Patients diagnosed with IPF according to current criteria and prescribed pirfenidone by one of 3 European specialist ILD centres were enrolled in a qualitative survey. One-to-one in-depth interviews were conducted between September and October 2012. <h3>Results</h3> 45 Participants (71% male; mean age 68.5 years). Mean time from diagnosis to interview 3.5 years. Post diagnosis, 68% of patients felt their knowledge about IPF severity, treatments and prognosis increased markedly, predominantly through the use of the internet. 32% of patients relied exclusively on information gained from the consultation and demonstrated a lack of understanding of the disease and its process. For all patients the transition to oxygen therapy signalled a significant change impacting upon the view of their future. O2 therapy was associated with social exposure of disease, often with feelings of “shame” (35%). This impacted quality of life: “restricting activity”; “making simple tasks difficult….even talking” and was associated with impaired emotional well-being (Figure 1). There was an overwhelming lack of psychological support (79%) as patients struggled to comprehend the disease process. Patients spontaneously identified specific approaches that could improve their disease experience. Pirfenidone was well tolerated and offered hope to the majority of patients (83%). However 44% of patients reported anxieties re continuing access. <h3>Conclusions</h3> Post diagnosis, many patients demonstrate resourcefulness in accessing information and have realistic expectations of how to improve care. There is a need to improve the information given in the consultation to improve subsequent understanding and to increase provision of psychological support particularly when prescribing O2 therapy. The availability of pirfenidone was perceived by patients to offer hope and reassurance. Strategies to reduce the delay in diagnosis and standardise access to information and therapies are needed.
Arrested hydrocephalus and the Round Britain Quiz
Authors: T. Dalrymple
Journal: BMJ (2012)

When I was young and aspiring to be an intellectual I used to listen to the Round Britain Quiz on BBC Radio 4, whose formidable contestants were sent cryptic questions by listeners that required for an answer both encyclopaedic knowledge and the skills of a cryptographer. How do you connect an Italian prime minister, a palace in Venice, and the heart of the matter? The answer (I will refrain from adding “of course”) is the nitty gritty: Nitti having been a prime minister of Italy, the Gritti being a palace in Venice, and the nitty gritty being . . . well, need I go on?

Here’s a question, then, for the quiz: how do …
1000 ROLE OF CALCIUM-CALMODULIN PATHWAY IN ESTRADIOL-17β-GLUCURONIDE INDUCED IMPAIRMENT OF CANALICULAR SECRETION IN ISOLATED RAT HEPATOCYTE COUPLETS
Authors: A. Zucchetti, F.D. Toledo, I.R. Barosso, E.J. Ochoa, F.A. Crocenzi, E.J. Sánchez Pozzi
Journal: Journal of Hepatology (2010)
Synthesis and pharmacokinetics of a novel macromolecular prodrug of Tacrolimus (FK506), FK506–dextran conjugate
Authors: Hiroshi Yura, Norio Yoshimura, Takashi Hamashima, Ken Akamatsu, Makiya Nishikawa, Yoshinobu Takakura, Mitsuru Hashida
Journal: Journal of Controlled Release (1999)
Uptake of lodine-131 by a Meekel??s Diverticulum Mimicking Metastatic Thyroid Cancer
Authors: ROBERT H. CAPLAN, GUNNAR A. GUNDERSEN, R MARIO ABELLERA, WILLIAM A. KISKEN
Journal: Clinical Nuclear Medicine (1987)

A 13-year-old girl demonstrated abnormal I-131 uptake in the abdomen after total thyroidectomy for recurrent papillary-follicular thyroid carcinoma. Although a vertebral metastasis was suspected, a negative bone scan and normal computed tomography of the vertebra militated against this diagnosis. A Tc-99m abdominal scintigram and a small bowel roentgenogram revealed images typical of a Meckel's diverticulum. Exploratory laparotomy did not reveal metastases, and I-131 uptake was no longer demonstrated after operative removal of the Meckel's diverticulum. Uptake of I-131 by a Meckel's diverticulum can mimic metastatic thyroid cancer.
The Prevalence of Meeting A1C, Blood Pressure, and LDL Goals Among People With Diabetes, 1988–2010
Authors: Sarah Stark Casagrande, Judith E. Fradkin, Sharon H. Saydah, Keith F. Rust, Catherine C. Cowie
Journal: Diabetes Care (2013)

OBJECTIVE To determine the prevalence of people with diabetes who meet hemoglobin A1c (A1C), blood pressure (BP), and LDL cholesterol (ABC) recommendations and their current statin use, factors associated with goal achievement, and changes in the proportion achieving goals between 1988 and 2010. RESEARCH DESIGN AND METHODS Data were cross-sectional from the National Health and Nutrition Examination Surveys (NHANES) from 1988–1994, 1999–2002, 2003–2006, and 2007–2010. Participants were 4,926 adults aged ≥20 years who self-reported a previous diagnosis of diabetes and completed the household interview and physical examination (n = 1,558 for valid LDL levels). Main outcome measures were A1C, BP, and LDL cholesterol, in accordance with the American Diabetes Association recommendations, and current use of statins. RESULTS In 2007–2010, 52.5% of people with diabetes achieved A1C &amp;lt;7.0% (&amp;lt;53 mmol/mol), 51.1% achieved BP &amp;lt;130/80 mmHg, 56.2% achieved LDL &amp;lt;100 mg/dL, and 18.8% achieved all three ABCs. These levels of control were significant improvements from 1988 to 1994 (all P &amp;lt; 0.05). Statin use significantly increased between 1988–1994 (4.2%) and 2007–2010 (51.4%, P &amp;lt; 0.01). Compared with non-Hispanic whites, Mexican Americans were less likely to meet A1C and LDL goals (P &amp;lt; 0.03), and non-Hispanic blacks were less likely to meet BP and LDL goals (P &amp;lt; 0.02). Compared with non-Hispanic blacks, Mexican Americans were less likely to meet A1C goals (P &amp;lt; 0.01). Younger individuals were less likely to meet A1C and LDL goals. CONCLUSIONS Despite significant improvement during the past decade, achieving the ABC goals remains suboptimal among adults with diabetes, particularly in some minority groups. Substantial opportunity exists to further improve diabetes control and, thus, to reduce diabetes-related morbidity and mortality.
THE PHYSICIAN AND HIS BANK
Authors: MERRYLE STANLEY RUKEYSER
Journal: JAMA (1927)

The recent revolution in American finance during which the banks became department stores of finance is of peculiar significance to physicians and other professional men. The change has transformed commercial banks from mere tools for business men into instrumentalities of use to all.  In prewar times, a bank was engaged almost exclusively in accepting deposits and extending credit. Banking was simple, and of restricted usefulness. Today the ultramodern banks and trust companies perform a complete circle of financial service, and have broadened their field to include the entire community. For example, the largest bank of the country, which might be expected to specialize in serving large corporations, solicits accounts in its compound interest department from individuals who can spare a dollar or more.  If the physician selects the modern type of bank, he need
Palliative removal of a giant polypoid 'carcinosarcoma' of the oesophagus by YAG laser photocoagulation of the tumour stalk.
Authors: D Richardson, J I Wyatt, K J Miloszewski
Journal: Gut (1992)

Dysphagia in a 79 year old lady was caused by a giant polypoid tumour in mid-oesophagus. Surgery was not appropriate. Shrinkage of the tumour and its eventual detachment were achieved by stopping its blood supply by YAG laser photocoagulation of the tumour stalk. Good, temporary palliation of the dysphagia was achieved.
Development Of In Vitro T Cell Priming Assays For Identification Of Contact Allergens And Respiratory Sensitizers
Authors: S.F. Martin, P.R. Esser, S. Schmucker, D. Pennino, R. Geiger, E. Maggi, L. Dietz, H. Thierse, A. Richter, A. Cavani, F. Sallusto
Journal: Journal of Allergy and Clinical Immunology (2010)
Serum Ferritin Levels in Hyperthyroidism
Authors: FRANK L. VAN DE VYVER
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 December 1982Serum Ferritin Levels in HyperthyroidismFRANK L. VAN DE VYVER, M.D., PIERRE P. BLOCKX, M.D., ROGER E. ABS, M.D., WALTER G. VAN DEN BOGAERT, JOZEF L. BEKAERT, M.D., PH.D.FRANK L. VAN DE VYVER, M.D.Search for more papers by this author, PIERRE P. BLOCKX, M.D.Search for more papers by this author, ROGER E. ABS, M.D.Search for more papers by this author, WALTER G. VAN DEN BOGAERTSearch for more papers by this author, JOZEF L. BEKAERT, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-97-6-930_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest the brief report by Drs. Macaron and Macaron on increased serum ferritin levels in hyperthyroidism (1). This report confirms our preliminary observations published in abstract form (2). Our initial investigation included 38 hyperthyroid patients, studied before and during therapy. A decrease of serum ferritin during antithyroid therapy was noted in most patients; 18 of the 20 patients, reaching the euthyroid state during this preliminary study, showed a fall in serum ferritin level. Our study currently includes 44 hyperthyroid patients who became euthyroid. In all but four patients, serum ferritin levels decreased during treatment,...References1. MACARONMACARON CZ. Increased serum ferritin levels in hyperthyroidism. Ann Intern Med. 1982;96:617-8. LinkGoogle Scholar2. VAN DE VYVERBLOCKXABSBEKAERT FPRJ. Influence of serum thyroid hormone levels on serum ferritin concentration [Abstract]. In: VAN DER VIJGH WJF, ed. Proceedings of the 23rd Dutch Federation Meeting. Amsterdam: The Dutch Foundation—Federation of Medical Scientific Societies; 1982:451. Google Scholar3. COOKLIPSCHITZMILESFINCH JDLC. Serum ferritin as a measure of iron stores in normal subjects. Am J Clin Nutr. 1974;27:681-7. CrossrefMedlineGoogle Scholar4. COLTON T. Nonparametric methods. In: COLTON T, ed. Statistics in Medicine. Boston: Little, Brown and Company; 1974:225-6. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University Hospital of Antwerpen B2520 Edegem Belgium PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIron metabolism in patients with Graves’ hyperthyroidismEndothelial Function in Patients with Hyperthyroidism Before and After Treatment with Propranolol and ThiamazolThyroid Hormone Modulates the Interaction between Iron Regulatory Proteins and the Ferritin mRNA Iron-responsive ElementThyroid hormone resistance in a large kindred: Physiologic, biochemical, pharmacologic, and neuropsychologic studies 1 December 1982Volume 97, Issue 6Page: 930-931KeywordsFallsHyperthyroidismSerum ferritin levels Issue Published: 1 December 1982 PDF downloadLoading ...
Intravenous omeprazole after endoscopic treatment of bleeding peptic ulcers
Authors: K R PALMER
Journal: Gut (2001)

<h3>Background</h3> Testing of vibration perception threshold (VPT) at the fingertips as a quantitative measure of tactile sensitivity is a commonly used tool in diagnosing hand–arm vibration syndrome. There is limited research on dose–response relationships between hand–arm vibration (HAV) exposure and VPT on an individual level. <h3>Aims</h3> Assess possible dose–response relationships on an individual level between HAV exposure and VPT at the fingertips. <h3>Methods</h3> We assessed average daily vibration exposure (m/s<sup>2</sup>A8) and cumulative lifetime HAV exposure for 104 participants from different departments in a road maintenance company based on vibration measurements and questionnaires. VPT was measured based on the technical method described in ISO 13091-1:2005 using octave frequencies 8–500 Hz. We investigated associations using linear regression models with significance level p≤0.05. <h3>Results</h3> The participants were either exposed to rock drills (n=33), impact wrenches (n=52) or none of these tools (n=19). Exposure to rock drills and impact wrenches was associated with elevated VPT for all seven test frequencies in the second and fifth fingers of both hands. A dose–response with the daily exposure measure m/s<sup>2</sup>(A8) was found based on 1.2 m/s<sup>2</sup>(A8) for impact wrenches, and 5.4 m/s<sup>2</sup>(A8) for rock drills. A stronger association was found with the cumulative exposure for rock drills compared with impact wrenches, and for the second finger compared with the fifth finger. <h3>Conclusions</h3> HAV exposure was associated with elevated VPT, also at exposure levels below the common exposure action value of 2.5 m/s<sup>2</sup>(A8). Lowering the HAV exposure can contribute to prevent increasing VPTs in these workers.
Poetry Is Stupid
Authors: Beatriz Rodriguez
Journal: Annals of Internal Medicine (2012)

Ad Libitum21 February 2012Poetry Is StupidBeatriz Rodriguez, MDBeatriz Rodriguez, MDFrom Rockford, IL 61107.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-156-4-201202210-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail “Poetry is stupid stuff,”my colleague said to me,“It's floaty like a vaporlike mist upon the sea.It doesn't make me smarteror help me feel well bredI don't need wily words, lassthat don't need to be said.Give me a real formulathat calculates the rateof oxygen's diffusionin alveolar spacethat is something I can usewhen breathing's kind of close.Pretty words just lying thereare useless and morose.Silly girl, so ponderous,content to spend your lightpruning dreams and parsing wordsdissecting wrong and right.Get on your coat, move aboutand come with me to seethe lives I change and bettermy stethoscope and me.”And my response was ... Author, Article, and Disclosure InformationAffiliations: From Rockford, IL 61107.Current Author Address: Beatriz Rodriguez, MD, 1826 Rothschild Lane, Rockford, IL 61107; e-mail, [email protected]com. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 February 2012Volume 156, Issue 4Page: 322KeywordsBreathingDeceptionInterleukinsOxygen ePublished: 21 February 2012 Issue Published: 21 February 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Alternative breast cancer drug shows promise
Authors: Allison Barrett
Journal: BMJ (2005)

The drug anastrozole (Arimidex) is more effective at inhibiting breast cancer recurrence than tamoxifen, a study published in the Lancet has found (2005;366:455-62). Researchers in Austria and Germany studied 3200 postmenopausal women who had received two years of tamoxifen, the current first line drug treatment for women with hormone responsive breast cancer. One randomised group continued receiving tamoxifen (1606 women), and the other took anastrozole alone (1618 women).

After a two year follow-up, the anastrozole group had 40% fewer events, defined as local recurrence, distant recurrence, or contralateral breast cancer. The tamoxifen group had 110 events, while the anastrozole …
Cysteine-rich domain of scavenger receptor Al modulates the efficacy of surface targeting and mediates internalization of oligomeric beta amyloid
Authors: Huey-Jen Tsay
Journal: Molecular Neurodegeneration (2013)

Results We found that SR-A variants with truncated exon 11 were intracellularly retained, whereas SR-A variants with further truncation into exon 10 were surface-targeted. Surface-targeted variants were fully glycosylated, whereas intracellularly-retained variants remained in high-mannose states. The fusion of exon 11 with a surface-targeted SR-A variant resulted in intracellular retention and a high-mannose state. Both the SRCR and collagenous domains mediated the ligand binding, but the collagenous domain was more important for matrix adhesion. Point mutations in a long stretch of b sheet 1, 2 and a loop region between b sheet 4 and 5 of the SRCR domain resulted in intracellular retention and a high-mannose state. Conclusions By identifying the function and critical motifs of the SRCR domain, our study suggests possible approaches to modulate innate immunity in Alzheimer’s disease and atherosclerosis.
Fludarabine‐mitoxantrone‐rituximab regimen in untreated intermediate/high‐risk follicular non‐Hodgkin's lymphoma: Experience on 142 patients
Authors: Pier Luigi Zinzani, Cinzia Pellegrini, Alessandro Broccoli, Beatrice Casadei, Lisa Argnani, Stefano Pileri
Journal: American Journal of Hematology (2013)

There is no international consensus on front-line optimal chemotherapy regimen for advanced stage follicular lymphoma (FL) patients, or a clear definition of cure for this disease. Aim of this study was to test the degree of effectiveness and the safety of the regimen containing fludarabine, mitoxantrone, and rituximab in a subset of poor prognosis FL patients with particular focus on the long-term disease-free survival. A retrospective study was conducted on 142 intermediate/high-risk FL patients treated in first-line with fludarabine, mitoxantrone, and rituximab regimen. Responses, safety, and survival were evaluated. The prognostic value of positron emission tomography (PET) was also investigated in a 56-patients subset. Overall response rate was 95.5% including 88% of complete responses. With a median follow-up of 48 months, 18% of patients had disease relapse, yielding an estimated 12-year disease-free survival (DFS) of 72%. All cases showed the lymphoma recurrence within 40 months: after this timing the DFS curve presented a plateau. Overall survival was 73% at 12 years. Post-treatment PET positivity remains a highly significant predictor of disease progression. The observed high rate of complete responses following the use of fludarabine, mitoxantrone-based regimen in combination with rituximab seems to be the first step to improve DFS. Our study could be the starting point to consider DFS as a potential alternative endpoint of future clinical trials on FL patients.
Authors' reply to Zermansky and Khatib
Authors: D. A. Hughes, J. Pink, S. Lane, M. Pirmohamed
Journal: BMJ (2011)

Zermansky and Khatib raise several points regarding our economic evaluation of dabigatran.1 In line with accepted health economic methods,2 we used the current list price of dabigatran. Although the availability of generics affects future pricing, new entrants have little effect on the price of the first to market drug.3 

We assumed that dabigatran would have no effect on anticoagulation clinics. …
Identifying Widely Covered Drugs and Drug Coverage Variation Among Medicare Part D Formularies
Authors: Chien-Wen Tseng, Carol M. Mangione, Robert H. Brook, Emmett Keeler, R. Adams Dudley
Journal: JAMA (2007)

Clinicians can find it difficult to know which drugs are covered for their Medicare patients because formularies vary widely among Medicare Part D plans and many states have 50 or more such plans.To determine whether Part D formularies in California (the state with the most Medicare beneficiaries) and Hawaii have at least 1 drug within each of 8 treatment classes for hypertension, hyperlipidemia, and depression that can be identified for clinicians as "widely covered" by the vast majority of Part D plans.Use of the medicare.gov Web site (March 1-April 15, 2006) to examine 72 California and 43 Hawaii Part D formularies' coverage of 8 treatment classes (angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta-blockers, calcium channel blockers, loop diuretics, selective serotonin reuptake inhibitors, statins, and thiazide diuretics), with evaluation of how often drugs were widely covered (defined as inclusion in >or=90% of formularies at co-payments of <or=$35 without prior authorization).Identification of treatment classes with at least 1 widely covered drug.For California, coverage for the 75 drugs examined ranged from 7% to 100%. Despite this variation, 7 of 8 classes (excluding angiotensin II receptor blockers) had at least 1 widely covered drug. Of the 34 widely covered drugs (45%), all but 2 were generic. Restricting widely covered to include 95% or more of formularies at co-payments of $15 or less still resulted in 7 of 8 classes with at least 1 widely covered drug. Overall, 73% of generic drugs and 6% of brand-name drugs were widely covered. Findings were similar for Hawaii.Formularies varied substantially; however, all but 1 treatment class examined had 1 or more widely covered drugs at low co-payments. Knowing which drugs are widely covered would assist clinicians in prescribing, since not all generic drugs were widely covered. Clinicians should know that few brand-name drugs are widely covered and check coverage before prescribing.