Hypopituitarism: A Study of Growth Hormone and Other Endocrine Functions
Authors: MITCHELL T. RABKIN
Journal: Annals of Internal Medicine (1966)

Article1 June 1966Hypopituitarism: A Study of Growth Hormone and Other Endocrine FunctionsMITCHELL T. RABKIN, M.D., ANDREW G. FRANTZ, M.D.MITCHELL T. RABKIN, M.D.Search for more papers by this author, ANDREW G. FRANTZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-6-1197 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo make the diagnosis of pituitary insufficiency a variety of approaches may be required. Among the simplest are those that evaluate physiological functions of the target organs. For example, the occurrence of regular menstrual cycles implies integrity of gonadotropin secretion. When physiological function is less easily assessed clinically, estimation of the hormonal output of the target gland is often used as an index of pituitary adequacy. Ideally, however, direct quantitation of the pituitary hormones themselves is preferable. The only pituitary hormones commonly measured directly are the gonadotropins, but the bioassay generally used is imprecise and does not always reliably distinguish...References1. YALOWBERSON RSSA: Immunoassay of endogenous plasma insulin in man. J. Clin. Invest. 39: 1157, 1960. CrossrefMedlineGoogle Scholar2. GLICKROTHYALOWBERSON SMJRSSA: Immunoassay of human growth hormone in plasma. Nature (London) 199: 784, 1963. CrossrefMedlineGoogle Scholar3. HUNTERGREENWOOD WMFC: A radioimmunoelectrophoretic assay for human growth hormone. Biochem. J. 91: 43, 1964. CrossrefMedlineGoogle Scholar4. GLICKROTHYALOWBERSON SMJRSSA: The regulation of growth hormone secretion. Recent Progr. Hormone Res. 21: 241, 1965. MedlineGoogle Scholar5. DAUGHADAYPARKER WHML: Human pituitary growth hormone. Ann. Rev. Med. 16: 47, 1965. CrossrefMedlineGoogle Scholar6. 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Hormone Res. 17: 53, 1961. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, MassachusettsFrom the Departments of Medicine, The Massachusetts General Hospital, and Harvard Medical School, Boston, Mass.This study was supported in part by grants AM-4080, AM-4501, and AM-5205, U. S. Public Health Service, Washington, D. C.Requests for reprints should be addressed to Mitchell T. Rabkin, M.D., The Massachusetts General Hospital, Boston, Mass. 02114. 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