tbuckley/cabot-search huggingface dataset:
Nosocomial Salmonellosis Due to Carmine
Authors: THEODORE C. EICKHOFF
Journal: Annals of Internal Medicine (1967)

Editorial Notes1 April 1967Nosocomial Salmonellosis Due to CarmineTHEODORE C. EICKHOFF, M.D.THEODORE C. EICKHOFF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-4-813 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptYet another facet of the epidemiology of salmonellosis has recently come to light—nosocomial infection by Salmonella cubana resulting from the diagnostic and investigative use of carmine. The first cases were noted by Lang and associates (1, 2) at the Massachusetts General Hospital. Within a few weeks, similar cases were observed in hospitals in California, Ohio, and Oregon and in England. The Salmonella Unit of the National Communicable Disease Center has learned of a total of 27 such cases, all resulting from the ingestion of carmine dye contaminated with S. cubana (3).Carmine is a purplish-red or crimson pigment widely used...References1. Morbidity and Mortality Weekly Report, vol. 15, no. 33. Communicable Disease Center, Atlanta, August 20, 1966, p. 282. Google Scholar2. LANGKUNZMARTINSCHROEDERTHOMSON DJLJARSALA: Carmine as a source of nosocomial salmonellosis. New Eng. J. Med. In press. Google Scholar3. Morbidity and Mortality Weekly Report, vol. 15, no. 48. Communicable Disease Center, Atlanta, December 3, 1966, p. 415. Google Scholar4. PAGECULVER LBPJ: A Syllabus of Laboratory Examinations in Clinical Medicine. Harvard University Press, Cambridge, 1960, p. 374. Google Scholar5. COLEZOLLINGER WHRM: Textbook of Surgery, 8th ed. Appleton-Century-Crofts, New York, 1963, p. 744. Google Scholar6. BOCKUS HL: Gastroenterology, vol. 2. W. B. Saunders Co., Philadelphia, 1964, p. 493. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: THEODORE C. EICKHOFF, M.D.Affiliations: Bacterial Diseases Section Communicable Disease Center U. S. Public Health Service Atlanta, Ga. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe “Carmine Problem” and Potential AlternativesMicrobial ContaminationProblems and methods of estimation of microbial contamination of nonsterile drugs (Review)CONTAMINATED MEDICINES 1 April 1967Volume 66, Issue 4Page: 813-814KeywordsEpidemiologyIngestionNosocomial infectionsSalmonellaSalmonellosis ePublished: 1 December 2008 Issue Published: 1 April 1967 PDF downloadLoading ...
Human colonic goblet cells. Demonstration of distinct subpopulations defined by mucin-specific monoclonal antibodies.
Authors: D K Podolsky, D A Fournier, K E Lynch
Journal: Journal of Clinical Investigation (1986)

We studied glycoprotein content of human colonic goblet cells, using a library of monoclonal antibodies (MAbs) directed against purified human colonic mucin (HCM). Using indirect immunofluorescence (IIF), we found that 17 of 23 anti-HCM MAbs stained some or all goblet cells of normal human colonic mucosa. We observed a variety of cellular staining patterns, including (a) diffuse (homogeneous) staining of intracellular mucin, (b) speckled (inhomogeneous) staining of mucin droplets, (c) peripheral staining of intracellular droplets, (d) cytoplasmic staining of goblet cells, and (e) apical (luminal) surface staining. Staining patterns were not associated with particular HCM species. In addition to variable patterns of IIF within individual cells, anti-HCM MAbs varied in the proportion of goblet cells stained. Some MAbs stained all goblet cells, while others stained a limited number of goblet cells. Although each goblet cell contained more than one type mucin, HCM species III, and IV and V appeared to exist in mutually exclusive goblet cell populations and it was possible to define at least seven subpopulations of goblet cells in colonic mucosa by their content of various combinations of HCM species. Anti-HCM MAbs stained goblet cells from other sites within the gastrointestinal tract to a varying extent. Anti-HCM MAbs also showed extensive cross-reactivity with rodent, rabbit, and monkey colonic mucosa. However, several anti-HCM MAbs stained only human colonic mucosa. These data show that human colonic mucosa contains discrete subpopulations of goblet cells that produce distinctive combinations of specific mucin glycoprotein species.
PRIORITY AS TO THE ACTIVATION OF FOODS BY ULTRAVIOLET RAYS
Authors: Alfred F. Hess
Journal: JAMA (1930)

<h3>To the Editor:</h3> —For some years, in referring to the discovery of the activation of foods by means of ultraviolet rays, I have stated that Hess and Steenbock made this observation "almost simultaneously." It seemed to me, in view of the fact that the discovery was made independently and so nearly at the same time, that this was a liberal way of stating the matter. However, in a recent paper published inThe Journal, Steenbock has placed the matter in a different light by the statement: "The experiments of Hess and his co-workers followed ours closely." It therefore appears necessary for me to be more definite in regard to chronological sequence. Such action is all the more advisable as this phrase has been quoted by other writers. My experiments with the use of ultraviolet rays in connection with the prevention and cure of rickets began in the spring of 1918
Pyarthrosis of the Hip Complicating Chickenpox
Authors: Roy E. Buck
Journal: JAMA (1968)

To the Editor:—  This case is an example of a rare but serious complication of a common childhood disease. Serious complications of chickenpox are now relatively rare. They were more frequent during the preantibiotic era, however, when the most common complication was secondary bacterial infection. Streptococci or staphylococci, usually introduced into the lesions by scratching, resulted in furuncles, impetigo, erysipelas, or septicemia.1,2Bone or joint infections have been rarely reported as sequels to chickenpox. Slowick3had one case of septic arthritis of the hip, and Green and Shannon4had two cases of osteomyelitis following chickenpox; in neither instance were any details reported.  Report of a Case:—  The patient was 4 years old in May 1964, when the characteristic symptoms and skin lesions of chickenpox developed in the patient and three siblings. Seven days later the patient complained of pain in the anterior part of the right thigh
The Success of the Antiseptic Treatment of Wounds Explained without Reference to Germs
Authors: R. T. Manson
Journal: BMJ (1870)

Occasionally pains coming and going, like small labour-pains, are ob- -served.And now I come to certain symptoms which are exceedingly interesting and important in their whole bearing, and which are very frequently present in cases of acute strangulation of the uterus: I mean the nervous and hysterical symptoms.Clinical observation has led me to the conclusion that, in cases of what may be termed acute hysteria attended with violent paroxysmal outbreaks, the pathological condition which lies at the root of the evil is strangulation of the uterus such as that above described.The truth of this theory, which, so far as I am aware, is a novel one as pro- pounded in this particular way, will, I am convinced, become evident to those who take the pains to investigate and dispassionately inquire *into the facts of individual cases.So much attention has been directed to the condition of the os and cervix uteri, to the exclusion, in too many instances, of the condition of the body and fundus of the uterus, that the connexion between these hysterical phenomena and marked flexion of the uterus leading, as I have explained, to strangulation of the organ, has been overlooked.I maintain that the connexion exists, and can be indubitably proved.The nervous symptoms produced by acute strangulation of the uterus might be accurately described after an c priori method.Acute conges-
Captopril in renovascular hypertension: long-term use in predicting surgical outcome.
Authors: A B Atkinson, A M Cumming, A F Lever, J J Morton, J J Brown, R Fraser, B Leckie, J I Robertson
Journal: BMJ (1982)

The angiotensin converting-enzyme inhibitor captopril was used as long-term preoperative treatment in a series of hypertensive patients with unilateral renal arterial disease.There were immediate and sustained falls in plasma angiotensin II and aldosterone concentrations, with converse increases in circulating renin and angio- tensin I.In patients with sodium and potassium deficiency and secondary aldosterone excess before treatment captopril corrected the sodium and potassium deficits; in these cases the initial hypotensive response was profound but the later effect was less pronounced.When sodium and potassium state was initially normal it remained unchanged during captopril treatment, while the full hypotensive effect took up to three weeks to be attained.The immediate, but not long-term, falls in arterial pressure with captopril were proportional to the immediate decrements of plasma angiotensin II.Never- theless, while the immedihte blood-pressure reduction with captopril variously overestimated and under- estimated the eventual surgical response, the absolute blood-pressure values during long-term captopril related well with those after operation.Pretreatment plasma renin and angiotensin H con- centrations, while closely predicting the immediate captopril response, are fallible guides to surgical progno-
PHYSICAL EXAMINATION OF RAILWAY MEN.
Authors: J. F. PRITCHARD
Journal: JAMA (1899)

When first making an investigation of this subject, about twelve years since, I was surprised to find its complete non-existence except in two systems of railway in which, for the purpose of insurance, examinations were made, but with no reference to service further than this might reach. In both instances there was then no examination made of vision or color perception. Gradually this has changed from an examination first made from a special train, and very hastily, until now, when a few railway systems employ competent examiners to make the tests; but I think there is yet great room for improvement. The recent examinations for service in the volunteer army demonstrated that there are many defective men, and if the temporary service in this war required such physical perfection, certainly the long and arduous service on a railway ought to require men of as perfect physical conformation as can be
Techniques for investigation of skin lymphatics
Authors: P.S. Mortimer, Caroline Young, R.L. Jones, T.J. Ryan
Journal: British Journal of Dermatology (1984)

Journal Article Techniques for investigation of skin lymphatics Get access P.S. Mortimer, P.S. Mortimer Department of Dermatology, The Slade Hospital, Oxford Search for other works by this author on: Oxford Academic Google Scholar Caroline Young, Caroline Young Department of Dermatology, The Slade Hospital, Oxford Search for other works by this author on: Oxford Academic Google Scholar R.L. Jones, R.L. Jones Department of Dermatology, The Slade Hospital, Oxford Search for other works by this author on: Oxford Academic Google Scholar T.J. Ryan T.J. Ryan Department of Dermatology, The Slade Hospital, Oxford Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue s26, 1 July 1984, Page 37, https://doi.org/10.1111/j.1365-2133.1984.tb05263.x Published: 01 July 1984
GMC was not "too lenient" with Southall
Authors: C. Williams
Journal: BMJ (2012)

Although Dickson is to be applauded for his partial apology to David Southall, I wonder who advised him on his response that the GMC was “too lenient.”1

In the Clark case, the Council for Healthcare Regulatory Excellence appealed the General Medical Council (GMC) decision, believing it to be too lenient. The court case proceeded on the basis that the panel decision was …
Anatomy Practical: An Epiphany
Authors: Megana Dwarakanath
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biological Monitoring for Depleted Uranium Exposure in U.S. Veterans
Authors: Carrie D. Dorsey, Susan M. Engelhardt, Katherine S. Squibb, Melissa A. McDiarmid
Journal: Environmental Health Perspectives (2009)

As part of an ongoing medical surveillance program for U.S. veterans exposed to depleted uranium (DU), biological monitoring of urine uranium (U) concentrations is offered to any veteran of the Gulf War and those serving in more recent conflicts (post-Gulf War veterans).Since a previous report of surveillance findings in 2004, an improved methodology for determination of the isotopic ratio of U in urine ((235)U:(238)U) has been developed and allows for more definitive evaluation of DU exposure. This report updates previous findings.Veterans provide a 24-hr urine specimen and complete a DU exposure questionnaire. Specimens are sent to the Baltimore Veterans Affairs Medical Center for processing. Uranium concentration and isotopic ratio are measured using ICP-MS at the Armed Forces Institute of Pathology.Between January 2003 and June 2008, we received 1,769 urine specimens for U analysis. The mean urine U measure was 0.009 microg U/g creatinine. Mean urine U concentrations for Gulf War and post-Gulf War veterans were 0.008 and 0.009 microg U/g creatinine, respectively. Only 3 of the 1,700 (0.01%) specimens for which we completed isotopic determination showed evidence of DU. Exposure histories confirmed that these three individuals had been involved in "friendly fire" incidents involving DU munitions or armored vehicles.No urine U measure with a "depleted" isotopic signature has been detected in U.S. veterans without a history of retained DU embedded fragments from previous injury. These findings suggest that future DU-related health harm is unlikely in veterans without DU fragments.
Abnormal maturation pathway of keratinocytes in psoriatic skin
Authors: B.A. BERNARD, SHIRLEY M. ROBINSON, SYLVIE VANDAELE, J.N. MANSBRIDGE, M. DARMON
Journal: British Journal of Dermatology (1985)

We compared the maturation pathway of normal and psoriatic epidermis using three different markers: (1) Involucrin, which is normally detected in the stratum granulosum in normal skin, was detected in all but the basal layer of involved psoriatic skin; (2) an antigen, recognized by the murine monoclonal antibody psi 3, was present in all but the basal layer of involved psoriatic skin but was absent from uninvolved and normal skin; (3) fibronectin, which normally localizes in the dermis and the epidermal-dermal junction, was also detected intra- and extracellularly in the psoriatic epidermis. These results indicate that the alterations in keratinocyte maturation found in psoriasis do not arise from a truncation of the normal maturation pathway but rather reflect the onset of an abnormal pathway of differentiation characterized by the expression of psi 3 antigen and fibronectin and the premature appearance of involucrin.
Atlas of Clinical Pathology of the Oral Mucous Membrane: A Practical Approach to Diagnosis
Authors: Noah D. Fabricant
Journal: JAMA (1960)

The second edition of this concise atlas of clinical pathology of the oral mucous membranes incorporates a number of new comments and illustrations which are useful for quick reference in clinical practice. As in the first edition, the oral diseases are summarized briefly under clinical features, course of the disease, differential diagnosis, etiology, frequency, and therapy. Each disease is illustrated by a color picture, and this, in turn, is followed by histopathologic descriptions (photographic as well as written) of the lesions. Without in any way attempting to compete with the more detailed publications in the field, this book should be invaluable for the otolaryngologist, dermatologist, internist, general practitioner, and dentist.
In vitro blood compatibility of polymeric biomaterials through covalent immobilization of an amidine derivative
Authors: M.-F. Gouzy, C. Sperling, K. Salchert, T. Pompe, U. Streller, P. Uhlmann, C. Rauwolf, F. Simon, F. Böhme, B. Voit, C. Werner
Journal: Biomaterials (2003)
Abstract 4207: DHA enhances genotoxic stress in prostate cancer cells through suppression of NF-κB
Authors: David A. Cavazos, Linda A. deGraffenried
Journal: Cancer Research (2011)

Abstract Excess levels of omega-6 fatty acids, commonly consumed in Western diets, are heavily implicated in contributing to prostate cancer incidence and tumor cell proliferation. Omega-6 fatty acids may promote worse outcome through the chronic production of eicosanoids that promote inflammation and oxidative stress. As omega-3 fatty acids competitively interact with some of the same rate-limiting enzymes to diminish inflammation and oxidative stress, epidemiologic studies have sought to determine if diets high in omega-3 fatty acids may impart beneficial effects on prostate cancer rates and progression. Pre-clinical observations indicate that omega-3 fatty acids suppress prostate tumor cell growth and induce cancer cell death, supporting a beneficial role of omega-3 fatty acids in delaying time to PSA failure and reducing the aggressiveness of advanced prostate cancer. As omega-3 fatty acids possess known pro-oxidant and antioxidant properties, we investigated the effects of docosahexaenoic acid (DHA-22:6n-3) in modulating oxidative DNA damage in normal and prostate cancer cells. Preliminary data demonstrates that prostate cancer cells (LNCaP) pretreated with DHA and pulsed with physiologic levels of H2O2 encounter a sustained G2 checkpoint arrest and exhibit decreased colony formation potential when compared to normal prostate epithelial cells (PrEC). LNCaP cells pulsed with 32 uM H2O2 exhibit DNA breaks associated with translocation of NF-κB into the nucleus, whereas pretreatment with DHA precluded NF-κB translocation, selectively sensitizing LNCaP cells, but not PrEC, to cell death. Further, DHA suppresses degradation of the NF-κB inhibitor, IκB, and attenuates NF-κB transcriptional activity as well as expression of the NF-κB downstream target, survivin. To conclusively demonstrate the critical role of NF-kB signaling in LNCaP cells after exposure to H2O2, we induced a 50% knockdown of p65 by siRNA and observe a complete ablation of colony formation relative to scrambled siRNA control vector. Here we describe one potential mechanism by which DHA may selectively increase genotoxicity in prostate cancer cells after exposure to oxidizing agents, ultimately setting the stage for Phase II clinical trials. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4207. doi:10.1158/1538-7445.AM2011-4207
A General Hospital as a Focus of Community Psychiatry
Authors: Leopold Bellak
Journal: JAMA (1960)

The psychiatry department of a general hospital can serve a preventive as well as a therapeutic function. The Trouble-Shooting Clinic here described combines the two aspects, serving in major emergencies as well as in minor problems involving guidance, on a walk-in basis, around the clock. Aiding the "lonely crowd" that exists in every community, it should become part of every hospital emergency service. An attempt is also made to propagate psychiatric understanding by seminars for key people of the community. A year-long course for general practitioners is given. Each week chaplains discuss psychiatric aspects of their work, and guidance teachers present cases. A seminar for lawyers focuses on psychiatric aspects of their daily clientele. Other programs are in preparation.
Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice
Authors: Hong Cui, Yasuo Okamoto, Kazuaki Yoshioka, Wa Du, Noriko Takuwa, Wei Zhang, Masahide Asano, Toshishige Shibamoto, Yoh Takuwa
Journal: Journal of Allergy and Clinical Immunology (2013)
Six Years’ Experience as a Psychosomaticist in a Hemodialysis Unit
Authors: H. Freyberger
Journal: Psychotherapy and Psychosomatics (1973)

Based on 58 dialysis patients, the psychological aspects of the rehabilitation procedure are discussed; a distinction is made between 'medical' and 'professional' rehabilitation. We describe the psychic troubles of our dialysis patients and their chances in mastering them. The various degrees of professional rehabilitation in our patients and the psychological traits which are connected with these are commented on. On the basis of 10 dialysis patients, the psychological aspects of home dialysis are discussed; particularly, the differences between the psychological situation of center dialysis and that of home dialysis, as well as the psychological criteria for the suitability of home dialysis, are considered. Finally, there is a discussion of the difficult psychosomatic problems which will occur in dialysis centers and in home dialysis in the future.
Associations Between The Expression Of Corticosteroid Regulated Genes By Peripheral Blood Mononuclear Cells (PBMCs) In Children From The NIH/NIAID Sponsored Asthma Phenotypes In The Inner City (APIC) Study
Authors: Elena Goleva, Leisa P. Jackson, Baomei Shao, Zheng Hu, Michelle A. Gill, Andrew H. Liu, Donald Y.M. Leung
Journal: Journal of Allergy and Clinical Immunology (2014)