Interferon-Gamma and Polymorphonuclear Leukocytes
Authors: David A. Watson
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 August 1988Interferon-Gamma and Polymorphonuclear LeukocytesDavid A. Watson, Daniel M. Musher, Richard J. HamillDavid A. WatsonSearch for more papers by this author, Daniel M. MusherSearch for more papers by this author, Richard J. HamillSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-3-250_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor:In his excellent review article on interferon-gamma, Murray (1) scrupulously avoids mentioning the controversial problem of the interaction between this lymphokine and polymorphonuclear leukocytes. Yet, whether interferon-gamma affects polymorphonuclear leukocytes remains unresolved. An answer might shed light, for example, on whether part of the host response to pulmonary infection reflects the generation by alveolar macrophages of lymphokines that influence polymorphonuclear leukocyte recruitment or function. Steinbeck and colleagues (2) suggested that pretreatment of polymorphonuclear leukocytes with interferon-gamma suppressed Chemotaxis but had no effect on phagocytosis, whereas Perussia and colleagues (3) found phagocytosis and bacterial killing to be enhanced...References1. Murray H. Interferon-gamma, the activated macrophage, and host defense against microbial challenge. Ann Intern Med. 1988;108:595-608. LinkGoogle Scholar2. Steinbeck M, Roth J, and Kaeberle M. Activation of bovine neutrophils by recombinant interferon-g. Cell Immunol. 1986;98:137-44. CrossrefMedlineGoogle Scholar3. Perussia B, Kobayashi M, and Rossi M. Immune interferon enhances functional properties of human granulocytes: role of Fc receptors and effect of lymphotoxin, tumor necrosis factor, and granulocyte-macrophage colony stimulating factor. J Immunol. 1987;138:765-74. CrossrefMedlineGoogle Scholar4. Shalaby M, Aggarwal B, and Rinderknecht E. Activation of human polymorphonuclear neutrophil functions by interferon-g and tumor necrosis factors. J Immunol. 1985;135:2069-73. CrossrefMedlineGoogle Scholar5. Murphy P, Lane H, Gallin J, and Fauci A. Marked disparity in incidence of bacterial infections in patients with the acquired immunodeficiency syndrome receiving interleukin-2 or interferon-g. Ann Intern Med. 1988;108:36-41. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: David A. Watson; Daniel M. Musher; Richard J. HamillAffiliations: Veterans Administration Medical Center Houston, TX 77030 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNeutrophil granulocytes as host cells and transport vehicles for intracellular pathogens: Apoptosis as infection-promoting factorSuppression of hypercholesterolemic atherosclerosis by pentoxifylline and its mechanismInterferon-gamma activation of polymorphonuclear neutrophil functionActivation of bovine neutrophil functions by interferon-gamma, tumour necrosis factor-alpha, and interleukin-1 alphaThe effect of tumor necrosis factor-α and interferon-γ on neutrophil function 1 August 1988Volume 109, Issue 3 Page: 250-251 Keywords Chemotaxis Homicide Macrophages Neutrophils Phagocytosis Pulmonary diseases ePublished: 1 December 2008 Issue Published: 1 August 1988 PDF downloadLoading ...