tbuckley/cabot-search huggingface dataset:
Efalizumab-induced aseptic meningitis
Authors: N. Kluger, C. Girard, V. Gonzalez, B. Guillot, D. Bessis
Journal: British Journal of Dermatology (2006)

Journal Article Efalizumab‐induced aseptic meningitis Get access N. Kluger, N. Kluger Université Montpellier I, Service de Dermatologie, Hôpital Saint‐Eloi, CHU Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France *Université Montpellier I, Service de Neurologie, Hôpital Gui‐de‐Chauliac, CHU Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France E‐mail: nicolaskluger@yahoo.fr Search for other works by this author on: Oxford Academic Google Scholar C. Girard, C. Girard Université Montpellier I, Service de Dermatologie, Hôpital Saint‐Eloi, CHU Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France *Université Montpellier I, Service de Neurologie, Hôpital Gui‐de‐Chauliac, CHU Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France E‐mail: nicolaskluger@yahoo.fr Search for other works by this author on: Oxford Academic Google Scholar V. Gonzalez, V. Gonzalez Université Montpellier I, Service de Dermatologie, Hôpital Saint‐Eloi, CHU Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France *Université Montpellier I, Service de Neurologie, Hôpital Gui‐de‐Chauliac, CHU Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France E‐mail: nicolaskluger@yahoo.fr Search for other works by this author on: Oxford Academic Google Scholar B. Guillot, B. Guillot Université Montpellier I, Service de Dermatologie, Hôpital Saint‐Eloi, CHU Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France *Université Montpellier I, Service de Neurologie, Hôpital Gui‐de‐Chauliac, CHU Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France E‐mail: nicolaskluger@yahoo.fr Search for other works by this author on: Oxford Academic Google Scholar D. Bessis D. Bessis Université Montpellier I, Service de Dermatologie, Hôpital Saint‐Eloi, CHU Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France *Université Montpellier I, Service de Neurologie, Hôpital Gui‐de‐Chauliac, CHU Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier cedex 5, France E‐mail: nicolaskluger@yahoo.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue 1, 1 January 2007, Pages 189–191, https://doi.org/10.1111/j.1365-2133.2006.07594.x Published: 01 January 2007
Plasma Urokinase Receptor Levels in Patients With Colorectal Cancer: Relationship to Prognosis
Authors: R. W. Stephens
Journal: JNCI Journal of the National Cancer Institute (1999)

The proteolytic enzyme plasmin, which is generated from the precursor plasminogen by the action of urokinase plasminogen activator, is thought to play a role in tumor cell invasion and metastasis. Urokinase plasminogen activator receptor (uPAR) is functionally involved in the cell surface activation (i.e., cleavage) of plasminogen. Increased tumor tissue levels of uPAR are associated with poor prognosis in several types of cancer. This retrospective study was undertaken to test the relationship between preoperative plasma levels of soluble uPAR (suPAR) and survival in patients with colorectal cancer.suPAR levels in preoperative plasma from 591 patients with colorectal cancer were determined by use of a kinetic enzyme-linked immunosorbent assay and analyzed with respect to associations with postoperative survival, Dukes' stage, age, and serum carcinoembryonic antigen level. Plasma suPAR measurements were log transformed for survival analysis, which employed the Kaplan-Meier method and the Cox proportional hazards model. All P values reported are two-sided.Univariate analysis, using the log-transformed suPAR concentrations, demonstrated that there was an increasing risk of mortality with increasing plasma suPAR level (P<.0001). An arbitrary cut point, the median for all patients (1.37 ng/mL), divided patients with Dukes' stage B, C, or D disease into statistically different prognostic groups. In multivariate Cox analysis including Dukes' stage, age, and carcinoembryonic antigen level, the suPAR concentration independently predicted survival (P<.0001).The preoperative plasma suPAR level independently predicted survival of patients with colorectal cancer. Further studies of plasma suPAR in patients with cancer are needed to evaluate the utility of plasma suPAR measurements and cut points in identifying high-risk patients among those with early stage disease.
130 Applicability and safety of extracorporeal liver support using albumin dialysis (MARS) in the setting of liver transplantation
Authors: M.-V. Catalina, C. Ripoll, G. Clemente, M. Salcedo, D. Rincon, A. Matilla, O. Nuñez, I. Beceiro, O. Lo Iacono, R. Bañares
Journal: Journal of Hepatology (2006)
Immunohistochemical analysis of Mallory bodies in Wilsonian and non-Wilsonian hepatic copper toxicosis
Authors: Thomas Müller, Cord Langner, Andrea Fuchsbichler, Peter Heinz-Erian, Helmut Ellemunter, Barbara Schlenck, Ashish R. Bavdekar, Avinash M. Pradhan, Anand Pandit, Josef Müller-Höcker, Michael Melter, Kunihiko Kobayashi, Hironori Nagasaka, Hideaki Kikuta, Wilfried Müller, Stuart M. Tanner, Irmin Sternlieb, Kurt Zatloukal, Helmut Denk
Journal: Hepatology (2004)

Patients with Wilson's disease (WD), Indian childhood cirrhosis (ICC), and idiopathic copper toxicosis (ICT) develop severe liver disease morphologically characterized by ballooning of hepatocytes, inflammation, cytoskeletal alterations, and Mallory body (MB) formation, finally leading to mostly micronodular cirrhosis. The pathogenesis of MBs in copper toxicosis is still unresolved. Immunohistochemical analysis of MBs in different types of copper intoxication revealed that keratin, p62, and ubiquitin are integral components. Thus MBs associated with copper intoxication resemble those present in alcoholic steatohepatitis (ASH) and nonalcoholic steatohepatitis (NASH). p62 is a multifunctional immediate early gene product that, on the one hand, is involved in stress-induced cell signaling (particularly that of oxidative stress) by acting as an adapter protein linking receptor-interacting protein (RIP) with the atypical protein kinase C. On the other hand, p62 binds with high affinity to polyubiquitin and ubiquitinated proteins. In conclusion, p62 accumulation in WD, ICC, and ICT and deposition in MBs indicates a central role of protein misfolding induced by oxidative stress in copper-induced liver toxicity. By sequestering potentially harmful misfolded ubiquitinated proteins as inert cytoplasmic inclusion bodies (e.g., as MBs), p62 may be a major player in an important cellular rescue mechanism in oxidative hepatocyte injury.
An anti–PR1/HLA-A2 T-cell receptor–like antibody mediates complement-dependent cytotoxicity against acute myeloid leukemia progenitor cells
Authors: Anna Sergeeva, Gheath Alatrash, Hong He, Kathryn Ruisaard, Sijie Lu, James Wygant, Bradley W. McIntyre, Qing Ma, Dan Li, Lisa St John, Karen Clise-Dwyer, Jeffrey J. Molldrem
Journal: Blood (2011)
Relation of the Adrenal Cortex to Rheumatic Disease: A Review of Some Recent Investigations
Authors: E. W. Boland
Journal: Annals of the Rheumatic Diseases (1950)

For years the literature has contained reports which have suggested that certain rheumatic diseases may be related, in some vague way, to the function of the endocrine glands.Some writers envisaged the possibility of an " endocrine rheumatism" and some even considered, along with other aetiological theories, that rheumatoid arthritis might be elicited through an obscure hormonal imbalance.Such ideas were ill-defined and lacked both experimental and direct clinical support.Recently, however, Hench, Kendall, Slocumb, and Polley, and subsequently others, have demonstrated that an adrenal cortical hormone (cortisone) and a pituitary adrenocorticotrophic hormone (ACTH) exert strikingly beneficial effects on avariety of rheumatic diseases.These observations now serve as strong evidence to link the pathogenesis of certain rheumatic diseases with the function of the endocrine glands, especially the adrenal cortex.APPLICATION OF ADRENAL CORTICAL FUNCTION TO THE RHEUMATIC DISEASES The reasoning which eventually led to the discovery that certain hormonal compounds exert powerful anti-rheumatic action was presented in detail by Henchl.*It has long been known that rheumatoid arthritis is capable of undergoing spon- taneous regression and that the course of the disease may be punctuated by spontaneous remissions, partial or complete, temporary or permanent.The disease, therefore, has the inherent capacity of spontaneous reversibility although the potentiality often remains dormant'.Certain procedures, heretofore apparently unrelated in their mode of action, are known to stimulate, though feebly, this potential reversibility and thereby to induce temporary amelioration of the disease.Such procedures include febrile reactions from foreign proteins, starvation, surgery, and surgical anaesthesias.More potent and more regular antagonists of rheumatoid arthritis are pregnancy, and jaundice from biliary obstruction or hepatitis2' 3, 4, , 6 7.Although the possible mechanism of * As this article presents an exceptional number of references, we have departed from the usual practice in this Journal.
The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus
Authors: Tassilo Volz, Lena Allweiss, Mounira Ben ḾBarek, Michael Warlich, Ansgar W. Lohse, Jörg M. Pollok, Alexander Alexandrov, Stephan Urban, Jörg Petersen, Marc Lütgehetmann, Maura Dandri
Journal: Journal of Hepatology (2012)
Chronic Structural Low Backache
Authors: N. Capener
Journal: Annals of the Rheumatic Diseases (1948)

<h3>OBJECTIVE</h3> To determine the effect of counseling patients to become more physically active. <h3>DATA SOURCES</h3> PubMed was searched for articles during the past 30 years on physicians promoting physical activity. Identified studies were cross-referenced, and experts were consulted for additional articles. <h3>STUDY SELECTION</h3> Thirteen articles described primary care counseling on exercise. Six studies were randomized controlled trials (RCTs); seven were quasi-experimental designs. Three of the four RCTs and three of the five quasi-experimental studies were short term (4 weeks to 2 months); the remaining three trials lasted longer than 6 months. Most studies used strategies to address stage of change. <h3>SYNTHESIS</h3> Outcome measures included adoption of physical activity, stage of change, and change in physical activity level. Most studies found positive relationships between counseling and these outcomes. No reliable evaluation instruments were found, nor was the long-term effect of interventions established. <h3>CONCLUSION</h3> Interventions that included written materials for patients, considered behaviour change strategies, and provided training and materials for physicians were effective at increasing levels of physical activity. New strategies that involve measuring and prescribing specific amounts of exercise might also improve fitness levels and hence improve outcomes of chronic disease. Shortcomings of these studies include lack of long-term data, lack of sustaining activities for family physicians, and scant cost-efficacy analysis.
A Run at Dusk
Authors: Joshua Latzman
Journal: Annals of Internal Medicine (2004)

Ad Libitum5 October 2004A Run at DuskJoshua Latzman, MDJoshua Latzman, MDFrom Manhasset, NY 11030.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-7-200410050-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Twilight approaching, the red-orange flamesdescend beyond the cityscape, leaves crunch underfootaround and around the reservoir you complete your trotsweating, heart pounding in your earsrunning along the splendid yearsTicking BEATing THUMPINGpumping countless liters across countriesof red-blue blood bathing sweetorgans with holy lifefifty-five years and you fallventricles crying fascicles fumblingyou, face down in the mud.clouds against a blue sky, you on your ... Author, Article, and Disclosure InformationAffiliations: From Manhasset, NY 11030.Current Author Address: Joshua Latzman, MD, North Shore University Hospital, 304 Community Drive, 1D, Manhasset, NY 11030. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 October 2004Volume 141, Issue 7Page: 536KeywordsBloodEmotionsFallsFearHeartRunning ePublished: 5 October 2004 Issue Published: 5 October 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
888 IMPROVEMENT OF LIVER DYSFUNCTION AFTER TREATMENT WITH N-ACETYL CYSTEINE IN PATIENT WITH ERYTHROPOIETIC PROTOPORHYRIA
Authors: J. Sperl, J. Petrasek, S. Frankova, S.M. Farrag, I. Subhanova, L. Vitek, M. Jirsa, J. Spicak, P. Martasek
Journal: Journal of Hepatology (2008)
US court to rule whether law's anti-prostitution policy requirement violated free speech rights
Authors: M. McCarthy
Journal: BMJ (2013)

The US Supreme Court heard oral arguments on 22 April about whether Congress can require HIV/AIDS programs working overseas to adopt explicit policies opposing prostitution and sex trafficking in order to secure federal funding.

The case—Agency for International Development et al (Petitioner) v Alliance for Open Society International Inc, et al—addresses a provision of the 2003 Leadership Against HIV/AIDS, Tuberculosis and Malaria Act,1 a global health funding legislation that has funneled billions of US dollars to international programs.

In that …
GAI Homologues in the Hawaiian Silversword Alliance (Asteraceae-Madiinae): Molecular Evolution of Growth Regulators in a Rapidly Diversifying Plant Lineage
Authors: David L. Remington, Michael D. Purugganan
Journal: Molecular Biology and Evolution (2002)

Accelerated evolution of regulatory genes has been proposed as an explanation for decoupled rates of morphological and molecular evolution. The Hawaiian silversword alliance (Asteraceae-Madiinae) has evolved drastic differences in growth form, including rosette plants, cushion plants, shrubs, and trees, since its origin ∼6 MYA. We have isolated genes in the DELLA subfamily of putative growth regulators from 13 taxa of Hawaiian and North American Madiinae. The Hawaiian taxa contain two copies of DaGAI that form separate clades within the Madiinae, consistent with an allotetraploid origin for the silversword alliance. DaGAI retains conserved features that have previously been identified in DELLA genes. Selective constraint in the Hawaiian DaGAI copies remains strong in spite of rapid growth form divergence in the silversword alliance, although the constraint was somewhat relaxed in the Hawaiian copies relative to the North American lineages. We failed to detect evidence for positive selection on individual codons. Notably, selective constraint remained especially strong in the gibberellin-responsive DELLA region for which the gene subfamily is named, which is truncated or deleted in all identified dwarf mutants in GAI homologues in different angiosperm species. In contrast with the coding region, however, ∼900 bp of the upstream flanking region shows variable rates and patterns of evolution, which might reflect positive selection on regulatory regions.
US judge allows class action over light cigarettes
Authors: Fred Charatan
Journal: BMJ (2006)

People who smoked “light” cigarettes because they thought that they were less harmful than ordinary ones can pursue their claim of fraud as a class action lawsuit, the US federal judge Jack Weinstein ruled last week. The lawsuit was filed in 2004 against Philip Morris, R J Reynolds, Lorillard Tobacco, British American Tobacco, and others.

“The plaintiffs are entitled to the chance to prove their allegations,” Judge Weinstein …
Observations on Prevention and Diagnosis of Anaemia in Pregnancy
Authors: C. Giles, H. Burton
Journal: BMJ (1960)

MEDICAL JOURNALfor an average period of three years after their first attendance at hospital.The results of treatment are analysed, showing that claudication in a large number of patients remained unchanged or improved on conservative treatment only.Angina and coronary thrombosis were common during the follow-up period, and the general mortality of this atherosclerotic group -is high.The position of long-term anticoagulant therapy is discussed.
Simulated Abuse of Tybamate in Man
Authors: Jack Shelton
Journal: JAMA (1967)

TYBAMATE is a chemical analogue of meprobamate which shares many of the pharmacological properties of the latter drug (Figure). These properties include sedative, anticonvulsant, and musclerelaxant effects. Tybamate differs from meprobamate in that it reverses the electroencephalographic activation produced by lysergic acid diethylamide tartrate (LSD-25) in rabbits, antagonizes the rise in blood pressure induced by serotonin in dogs, and is extensively bound to protein.<sup>1</sup>A number of clinical reports, including some double-blind comparisons with placebo and meprobamate, attest to its clinical efficacy.<sup>2,3</sup>Despite considerable clinical use, so far no instances of withdrawal reactions have been encountered. Early investigations suggested freedom from withdrawal effects. Even when administered over a long period of time to dogs in doses of 570 mg/kg of body weight; no withdrawal seizures were encountered; dogs treated with comparable doses of meprobamate had frequent withdrawal seizures, often fatal.<sup>4</sup> As canine withdrawal reactions have correlated well
Bevacizumab for the Treatment of Epithelial Ovarian Cancer: Will This Be Its Finest Hour?
Authors: Stanley B. Kaye
Journal: Journal of Clinical Oncology (2007)

Few would argue that one of the key success stories of the modern era of molecular targeted therapy for cancer has been the demonstration that an antiangiogenic approach confers therapeutic benefit in several adult malignancies. If one had been asked 5 years ago to predict the tumors in which this would be most likely tobeseen,thereisnodoubtthatepithelialovariancancerwouldbe very high on most lists. The reason relates to the biology of the disease. Angiogenesis, which is controlled by a range of proangiogenic factors, particularly including those in the vascular endothelial growth factor (VEGF) family of proteins, plays a central role in the physiological function of the healthy ovary. It could therefore be anticipated that the abnormal angiogenesis that characterizes malignancy would be especially relevant in this disease. 1 Preclinical studies with appropriate models have indeed indicated the potential for an anti-VEGF strategy in preventing tumor progression and reducing the formation of malignant effusions. 2 In addition, numerous studies indicate a direct correlation between angiogenic factors and disease extent and progression. 3 It is, therefore,nosurprisetoreadintworeportsinthisissueoftheJournalof Clinical Oncology 4,5 that bevacizumab, the humanized anti-VEGF monoclonal antibody, does indeed possess significant single-agent activity in patients with relapsed epithelial ovarian cancer. It is instructive to compare these data with clinical experience in other tumors. Bevacizumab possesses minimal single-agent activity in morecommonepithelialcancerssuchascolorectal,non‐small-cell
Research interests: behind the biological sample
Authors: E. H. Tajara, L. L. Villa, M. B. d. Carvalho
Journal: BMJ (2014)

The GENCAPO (or Head and Neck Genome) project has been run since 2002 by a group of Brazilian surgeons, epidemiologists, pathologists, and biologists. The project aims to describe head and neck cancer signatures and understand the many clinical, diagnostic, and prognostic aspects of such tumours. More than 3500 patients have been interviewed, and many biological samples have been collected and analysed. However, alongside our enthusiasm for the research, a question has concerned and depressed us: what are we giving back to our patients?

We know that we cannot cure all of them or even, after invasive and sometimes disfiguring surgery, improve their quality of …
Chronic Pyelonephritis—Essential or Primary Versus Secondary.
Authors: Harry Seneca
Journal: Annals of Internal Medicine (1965)

s1 November 1965Chronic Pyelonephritis—Essential or Primary Versus Secondary.Harry Seneca, M.D., F.A.C.P.Harry Seneca, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-920_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBacteriological, immunological, and clinical survey of 30 cases of essential or primary and 84 cases of secondary (calculus or obstructive) pyelonephritis reveal that: (1) Essential pyelonephritis is a very serious disease having a higher mortality rate than secondary pyelonephritis; (2) in secondary pyelonephritis, after the surgical management of the urological pathology, chemotherapy controls or cures the infection. In essential pyelonephritis, chemotherapy fails to control the infection. Prolonged suppressive therapy helps; (3) in essential pyelonephritis, the mechanism of antibody production or immunity is inadequate. In 30 cases of essential pyelonephritis, 57 pathogens were cultured from the urine, and the blood sera... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Harry Seneca, M.D., F.A.C.P.Affiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1965Volume 63, Issue 5Page: 920-920KeywordsChemotherapyClinical pathologyDeath ratesImmunityInfectious disease controlInfectious disease immunologyPathogensPyelonephritisUrineUrologic infections ePublished: 1 December 2008 Issue Published: 1 November 1965 PDF downloadLoading ...
Conspiracy of silence
Authors: M D Schwartz, A Kalet
Journal: BMJ (1994)

Between 1951 and 1963, 126 atomic explosions rocked the desert of the Nevada test site, an area considered “virtually uninhabited” by the United States Atomic Energy Commission. In 1979 Carole Gallagher, photographer and documentarian, discovered a declassified memo from the commission which described people living downwind of the test site as “a low-use segment of the population.” This simple statement led her to spend 10 years interviewing and photographing these “downwinders.” The resulting photographs and oral histories were on show at the International Center of Photography in New York City, April-June 1994, and have been published by MIT Press.

The exhibition begins with a map from the commission showing the nuclear fallout paths. It disturbingly shows how fallout clouds were carried throughout North America - making us all downwinders. Next are stark images of destroyed desert landscape, altered by unimaginably powerful underground explosions - mountains were literally moved. To us the most eerie photograph, however, was of an empty children's playground 10 miles from ground zero, which seemed to emit muffled sounds of children playing.

The hardy faces of the “downwinders,” captured in black and white portraits, are as weathered and tragic as the surrounding landscape. Their stories, in their own words, are displayed beside each picture.

These are stories of the personal consequences of radiation …