tbuckley/cabot-search huggingface dataset:
Significant increased recurrence rates among breast cancer patients with HER2-positive, T1a,bN0M0 tumors.
Authors: R Rakkhit, K Broglio, F Peintinger, F Cardoso, EO Hanrahan, JK Litton, A Sahin, D Larsimont, F Meric-Bernstam, TA Buchholz, V Valero, RL Theriault, M Piccart, P Ravdin, GN Hortobagyi, AM Gonzalez-Angulo
Journal: Cancer Research (2009)

Abstract Abstract #701 Background: Controversy surrounds the prognosis of breast cancer patients with T1a,bN0M0 tumors following locoregional therapy and the need for adjuvant systemic therapy, especially for HER2+ disease. The purposes of the study were to determine the recurrence-free survival (RFS), and distant recurrence-free survival (DRFS) in small HER2+ tumors compared with hormone receptor ( HR)+ and triple receptor- (TN) tumors.&amp;#x2028; Methods: Stage T1a,bN0M0 breast cancers diagnosed between 1973-2003 were reviewed by dedicated breast pathologists. HER2+ tumors were defined as 3+ by IHC or gene amplification. Patients were categorized into 3 groups:TN (ER-, PR-and HER2-), HER2+ (regardless of HR status) and HR+ (HER2-). RFS and DRFS were estimated by the Kaplan-Meier method and compared with the log-rank test. Cox proportional hazards models were fit to determine the association of each group with the risk of recurrence after adjustment for other characteristics.&amp;#x2028; Results: Of the 1796 patients, 427 were excluded from the analysis due to being male (2), lack of receptor information (249), and adjuvant chemotherapy (176) leaving 1369 pts for analysis. Median age was 57 years,(range, 26-88). There were 381(28%) T1a and 988(72%) T1b tumors; HR+ 68%, TN 23%, HER2+ 9%. Patients who had HER2+ breast cancer tended to be younger,(p=0.001); have more T1a tumors, (p=0.001); and have higher nuclear grade,(p&amp;lt;0.001). At a median follow-up of 74 months(range 1-350), there were 160 recurrences and 77 distant metastases. Five and 10-year RFS and DRFS are summarized in the table. After adjustment for other characteristics, patients with HER2+ breast cancer had a significantly worse RFS (HR: 5.19, 95% CI: 3.21-8.39, p&amp;lt;0.0001) and DRFS (HR: 4.66, 95% CI: 2.47-8.80, p&amp;lt;0.0001) compared to patients with HR-positive breast cancer.&amp;#x2028; Conclusions: Breast cancer patients with HER2+ T1a,bN0M0 tumors have a significant risk of relapse and should be considered candidates for adjuvant systemic therapy including anti-HER2 agents.&amp;#x2028; &amp;#x2028; Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 701.
Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques.
Authors: V A Folcik, R A Nivar-Aristy, L P Krajewski, M K Cathcart
Journal: Journal of Clinical Investigation (1995)

Oxidized LDL is present in human atherosclerotic lesions, but the mechanisms responsible for oxidation in vivo have not been definitively demonstrated. Circumstantial evidence has implicated the enzyme 15-lipoxygenase as a contributor to the formation of oxidized lipids in this disease. To assess whether oxidized lipids are indeed formed by the action of 15-lipoxygenase on polyunsaturated fatty acids (PUFAs) in vivo, we have used a sensitive and specific method (chiral phase HPLC) to analyze the lipid oxidation products present in human atherosclerotic lesions. Human 15-lipoxygenase is an omega-6 lipoxygenase that has previously been shown to oxidize esterified PUFA in a stereospecific manner, forming predominantly cholesteryl hydroperoxy-octadecadienoate (13(S)-HPODE) from cholesteryl linoleate substrate in LDL. This property allows its activity to be distinguished from nonenzymatic oxidation, which results in the formation of equal quantities of the S and R stereoisomers of the same oxidation product. A total of 80 specimens of human atherosclerotic plaque were analyzed. Esterified, oxidized linoleate was purified from human atherosclerotic lesions and from LDL oxidized by copper, and the chirality of these oxidation products was compared. There was significantly greater stereospecificity of oxidation in the oxidized linoleate from human atherosclerotic lesions. Even greater stereospecificity was detected in the HPODE derived from cholesteryl ester, purified from human lesions. Cholesteryl HPODE is the primary oxidation product from cholesteryl linoleate, the major esterified PUFA that accumulates in atherosclerotic vessels. Cholesteryl HPODE and its reduced form, cholesteryl hydroxy-octadecadienoate, were detected in all lesions analyzed. Neither the stereospecificity of oxidation nor the percentage of available substrate oxidized to primary oxidation products was correlated with the stage of disease of the lesions examined. We conclude that 15-lipoxygenase contributes to the formation of oxidized lipids in human atherosclerotic lesions.
Long-term safety of topical calcitriol 3 mug g-1 ointment
Authors: M.J.P. Gerritsen, P.C.M. van de Kerkhof, A. Langner
Journal: British Journal of Dermatology (2001)

Journal Article Long‐term safety of topical calcitriol 3 μg g−1 ointment Get access M.J.P. Gerritsen, M.J.P. Gerritsen Department of Dermatology, University Hospital Nijmegen, PO Box 9101, 6500 HB Nijmegen, the Netherlands Dr. M. Gerritsen Fax: +31 (0) 2435 41184 Search for other works by this author on: Oxford Academic Google Scholar P.C.M. Van De Kerkhof, P.C.M. Van De Kerkhof Department of Dermatology, University Hospital Nijmegen, PO Box 9101, 6500 HB Nijmegen, the Netherlands Search for other works by this author on: Oxford Academic Google Scholar A. Langner A. Langner Dermatology Department, Medical University of Warsaw, Poland Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 144, Issue s58, 1 April 2001, Pages 17–19, https://doi.org/10.1046/j.1365-2133.2001.144s58017.x Published: 01 April 2001
&lt;emph type="ital"&gt;The Botanists (Die Botaniker)&lt;/emph&gt;
Authors: Janet M. Torpy
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PRURIGO (HEBRA) AS OBSERVED IN THE UNITED STATES.
Authors: WILLIAM THOMAS CORLETT
Journal: JAMA (1904)

The opinion is held by some that prurigo, as met with in Vienna, does not exist in this country. It is true that cases from time to time have been reported by Zeisler and others, who are familiar with the disease as it exists in Austria, and while there has been a<i>quassi</i>acceptance of these reports, yet they are looked on by many as unique. In England, previous to the International Dermatological Congress, which met in London in 1896, the prurigo of Hebra was unknown. At this congress cases were collected which it was thought corresponded in many ways to those observed in Vienna. These cases were examined by Kaposi and others, who confirmed the diagnosis of prurigo (Hebra), which established the fact that the disease was encountered in England, and to some of the American dermatologists present demonstrated that the prurigo as observed
Convergent Evolution of Clustering of Iroquois Homeobox Genes across Metazoans
Authors: M. Irimia, I. Maeso, J. Garcia-Fernandez
Journal: Molecular Biology and Evolution (2008)

Vertebrate and Drosophila Iroquois genes are organized in clusters of 3 genes sharing blocks of conserved regulatory sequences. Here, we report a 3-gene cluster in the basal, preduplicative chordate amphioxus. Surprisingly, however, the origin of the amphioxus cluster is independent of those in vertebrates and drosophilids. Investigation of genomic organization of Iroquois genes in other 17 metazoan genomes revealed a fourth independent 3-gene cluster organization in polychaetes, as well as additional 2- and 4-gene clusters in other clades, in one of the most striking examples of convergence in genomic organization described so far. The recurrent independent evolution of Iroquois clusters suggests a functional importance of this organization for these genes, perhaps related to the sharing of regulatory elements. Consistent with this, comparative analysis of genomic regions flanking the 3 amphioxus Irx genes revealed several blocks of sequences, conserved for at least 100 Myr. Finally, we discuss the possible causes and implications of the convergent evolution of this genomic and regulatory organization throughout metazoans.
Matrix metalloproteinase‐9: a novel biomarker for monitoring disease activity in patients with chronic urticaria patients?
Authors: S. Altrichter, N. Boodstein, M. Maurer
Journal: Allergy (2009)

Matrix metalloproteinase (MMP)-9, an enzyme that contributes to inflammatory responses and subsequent tissue remodelling, has recently been suggested to be a good biomarker for monitoring disease activity in patients with chronic urticaria (CU). Here, we assessed whether total MMP-9 and/or active MMP-9 plasma levels are increased and correlated to disease activity in patients with CU.Total MMP-9 and active MMP-9 plasma levels were determined by ELISA in 70 CU patients and control subjects (patients with psoriasis and healthy controls). CU activity was measured using weekly and daily composite symptom scores (urticaria activity score) calculated from the number of wheals and the intensity of pruritus.Significantly increased levels of total and active MMP-9 were detected in patients with CU as compared to healthy controls. Interestingly, patients with psoriasis also had clearly elevated plasma levels of total and active MMP-9, indicating that MMP-9 plasma levels do not specifically reflect CU activity. Most notably, total and active MMP-9 levels were not correlated with disease activity in CU or psoriasis patients.Plasma MMP-9 is not a good CU biomarker and should not be used for assessing the efficacy of treatment in CU patients or their spontaneous changes in disease activity.
Clinical significance of antibodies to native DNA as measured by a DNA binding technique in patients with articular features of rheumatoid arthritis.
Authors: D M Grennan, D Sloane, A Behan, W C Dick
Journal: Annals of the Rheumatic Diseases (1977)

The clinical significance of antinative DNA antibodies as measured by the Farr test was investigated in 10 patients with the articular features of rheumatoid arthritis. 5 of these patients also satisfied criteria for a diagnosis of systemic lupus erythematosus (SLE) and might be classified as rheumatoid/lupus overlap syndromes or as rheumatoids with systemic complications. None had evidence of renal disease and 3 of the 5 had Sjgøren's syndrome. The sixth patient had aggressive peripheral arthritis, alopecia, and Sjøgren's syndrome and developed anti-DNA antibodies after treatment with penicillamine. All of the 4 rheumatoid patients with no clinical features typical of SLE had some special disease feature. The first had subclinical liver disease and the other 3 had Sjøgren's syndrome in addition to localized vasculitic skin ulceration (2) and pulmonary fibrosis (1).
Utility of flow cytometric reticulocyte quantification as a predictor of engraftment in autologous bone marrow transplantation
Authors: Bruce H. Davis, Nancy Bigelow, Edward D. Ball, Letha Mills, Gibbons G. Cornwell
Journal: American Journal of Hematology (1989)

Abstract Flow cytometric reticulocyte quantification with thiazole orange (TO) was used to study erythropoiesis in 20 patients following autologous bone marrow transplantation for the treatment of acute myelogenous leukemia. Flow cytometric reticulocyte analysis provided not only the reticulocyte percentage and absolute reticulocyte count but a quantitative reticulocyte maturity index (RMI) proportional to the amount of RNA in the reticulocytes. The RMI values, but not the reticulocyte percentage or absolute counts, correlated temporally with the rise in the absolute neutrophil counts in the posttrans‐plantation period. In the majority of patients (12/20), the RMI value was the earliest indicator of bone marrow engraftment. The findings of this study demonstrate an important clinical utility of TO reticulocyte analysis by flow cytometry and indicate the diagnostic importance of the RMI measurement in the evaluation of erythropoietic activity in bone marrow transplant patients.
Glutathione <i>S-</i> Transferase P1, Maternal Smoking, and Asthma in Children: A Haplotype-Based Analysis
Authors: Yu-Fen Li, W. James Gauderman, David V. Conti, Pi-Chu Lin, Edward Avol, Frank D. Gilliland
Journal: Environmental Health Perspectives (2007)

BackgroundGlutathione S-transferase P1 (GSTP1) plays a role in a spectrum of respiratory diseases; however, the effects of sequence variation across the entire locus in asthma pathogenesis have yet to be determined.ObjectivesThis study was designed to investigate whether sequence variations in the GSTP1 coding and promoter regions are associated with asthma and wheezing outcomes and to determine whether variants affect susceptibility to maternal smoking.MethodsFour haplotype tagging SNPs were selected that accounted for 83% of the common haplotypic variation in GSTP1. The associations of GSTP1 variants with asthma and wheezing were assessed among white children in the Children's Health Study (CHS).ResultsThe Ile105Val allele and a SNP in the upstream promoter region (SNP1: rs6591255, putative transcription factor 1 binding site) were associated with asthma and wheezing outcomes, an association observed in two cohorts of the CHS recruited in different years. Haplotypes that included both the promoter SNP (i.e., rs6591255) and the 105 Val variant were associated with an increased risk for asthma in non-Hispanic whites. Using SNP- and haplotype-based approaches, the effect of maternal smoking on wheezing was largest in children with the Ile105Val allele.ConclusionsVariants in both the promoter and coding regions of the GSTP1 locus may contribute to the occurrence of childhood asthma and wheezing and may increase susceptibility to adverse effects of tobacco-smoke exposure.
Transposition of the Great Vessels
Authors: JOHN D. KEITH, C. A. NEILL, PETER VLAD, R. D. ROWE, A. L. CHUTE
Journal: Circulation (1953)

The vast majority of cases of transposition of the great vessels can be diagnosed in the first few weeks of life with electrocardiogram, x-ray and fluoroscope. The clinical pattern and the diagnostic features are described in detail. The degree of cyanosis, the characteristic heart shape and progressive increase in size coupled with generous hilar shadows all suggest this diagnosis. A new suggestion is made regarding possible surgical therapy using an extracorporeal circulation.
Abstract 447: A mechanism of hypoxia-induced immune escape in cancer cells
Authors: Thomas K. Hamilton, Ivraym Barsoum, Xin Li, Ellen A. Miles, Janet Elliott, D. Robert Siemens, Charles H. Graham
Journal: Cancer Research (2011)

Abstract We previously showed that hypoxia induces resistance to natural killer (NK) cell-mediated lysis in tumor cells through a mechanism that involves the shedding of NK cell-activating ligands (MICA) from the cell surface. Furthermore, we were able to block this hypoxia-induced shedding of MICA, as well as resistance to NK cell-mediated lysis, by activating NO signaling in the cancer cells. The objective of the present study was to fully elucidate this mechanism of hypoxia-induced immune escape. We used siRNA knock-down to determine the role of hypoxia-inducible factor-1 (HIF-1), a transcriptional activator of hypoxia-inducible genes, and ADAM10, a metalloproteinase known to be involved in the shedding of MICA, in the hypoxia-induced immune escape in DU145 prostate cancer cells and MDA-MB-231 breast cancer cells. Our findings revealed that in vitro exposure to hypoxia increases ADAM10 expression in a HIF-1-dependent manner, and that knock-down of ADAM10 abolishes the hypoxia-induced MICA release and resistance to NK cell-mediated lysis. Treatment of the tumor cells with low concentrations of nitroglycerin inhibited the hypoxia-induced accumulation of HIF-1α, ADAM10 up-regulation, the shedding of the NK-activating ligands, and resistance to NK cell-mediated lysis. More importantly, continuous transdermal administration of nitroglycerin (1.8 µg/h) to nude mice attenuated the growth of transplanted human DU145 prostate tumors; however, this effect of nitroglycerin was lost in mice made deficient in NK cells by treatment with anti-asialo GM1 antibody. This latter finding indicates that nitroglycerin attenuates tumor growth by sensitizing tumor cells to innate immunity. These findings are important because they indicate that nitric oxide mimetics could potentially be used as immunosensitizers in the treatment and/or prevention of cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 447. doi:10.1158/1538-7445.AM2011-447
TCT-26 Comparison of everolimus-eluting and paclitaxel-eluting coronary stents in patients undergoing primary percutaneous coronary intervention: 5 year follow-up from the COMPARE I trial
Authors: Georgios J. Vlachojannis, Kees-Jan Royaards, Marielle A. Koper, Adriaan O. Kraaijeveld, Bianca M Boxma-de Klerk, Jochem Wassing, Martin van der Ent, Pieter C. Smits
Journal: Journal of the American College of Cardiology (2014)
Minimal portal vein stenosis is a promising preconditioning in living donor liver transplantation in porcine model
Authors: E. Gregoire, P. Brige, L. Barbier, C. Buffat, A. Coppola, J. Hardwigsen, Y.P. Le Treut, V. Vidal, P.H. Rolland
Journal: Journal of Hepatology (2014)
Applying Health Care Reform Principles to Mental Health and Substance Abuse Services
Authors: Kavita Patel
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Doxorubicin and the Heart
Authors: ROLAND A. LEVANDOWSKI
Journal: Annals of Internal Medicine (1980)

Letters and Corrections1 June 1980Doxorubicin and the HeartROLAND A. LEVANDOWSKI, M.D.ROLAND A. LEVANDOWSKI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-6-866 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent letter Cosgriff(1) reported onset of ventricular dysrhythmia in a 21-year-old man after administration of doxorubicin and noted the association of doxorubicin, dysrhythmia, and sudden death. Experimental data suggest that doxorubicin-associated dysrhythmias may be commoner than presently appreciated and that sudden deaths related to doxorubicin may be the result of primary hemodynamic as well as dysrhythmic changes.Hemodynamic and electrophysiologic effects of doxorubicin have been investigated in a canine model. Administration of 80 mg/m2of doxorubicin to anesthetized healthy dogs caused an immediate profound fall in mean intra-arterial blood pressure (80 mm Hg in one...References1. COSGRIFF T. Doxorubicin and ventricular arrhythmia. Ann Intern Med. 1980;92:434-5. Letter. LinkGoogle Scholar2. LEVANDOWSKI R. Electrophysiologic effects of adriamycin on the heart. In Proceedings of Workshop: Discussions of Pathogenesis and Treatment of Adriamycin Cardiotoxicity, Session 3. Dayton, Ohio: Wright State School of Medicine and Cox Heart Institute; 29-30 September 1975: pp. 6-10. Google Scholar3. KEHOESINGERTRAPANIBILLINGHAMLEVANDOWSKIELSON RDAMRJ. Adriamycin-induced dysrhythmias in an experimental dog model. Cancer Treat Rep. 1978;62:963-78. MedlineGoogle Scholar4. CORTESLUTMANWANKA EGJ. Adriamycin (NSC-123127) cardiotoxicity: a clinicopathologic correlation. Cancer Chemother Rep. 1975;6:215-25. Google Scholar5. O'BRYANLUCETALLEY RJR. Phase II evaluation of adriamycin in human neoplasia. Cancer. 1973;32:1-8. CrossrefMedlineGoogle Scholar6. WORTMANLUCASSCHUSTER JVE. Sudden death during doxorubicin administration. Cancer. 1979;44:1588-91. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROLAND A. LEVANDOWSKI, M.D.Affiliations: University of Illinois Chicago, IL 60680 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEffects of first-dose doxorubicin on cardiac rhythm as evaluated by continuous 24-hour monitoringCardiac and vascular effects of elliptinium in guinea pigs. Involvement of a histaminergic mechanism 1 June 1980Volume 92, Issue 6Page: 866-867KeywordsBlood pressureFallsHeartHemodynamics ePublished: 1 December 2008 Issue Published: 1 June 1980 PDF downloadLoading ...
Substandard Care, Antidumping, and George Orwell-Reply
Authors: Helen R. Burstin
Journal: JAMA (1993)

In Reply.  —We share Dr Gaddis' concerns regarding the care of the medically indigent in emergency departments. As he correctly points out, our data collection efforts preceded antidumping legislation. However, we did not find that patients were turned away from emergency departments but instead were treated in the emergency department in a substandard fashion. None of the cases we uncovered would have been actionable under COBRA. Emergency departments that rely on physicians trained in emergency medicine may provide higher quality care, but we were unable to comment on this issue for our study. Our concerns about health care in the emergency department have in part led us to undertake a multiple institution study of emergency department care.  Dr Evans' description of George Orwell's experience as a poor patient in a hospital is very dramatic. Orwell's dramatization, however, suggests sinister intentions or gross callousness. Our concern is with the system of