tbuckley/cabot-search huggingface dataset:
Assessment of Clinical and Pathologic Characteristics Predisposing to Disease Recurrence Following Radical Prostatectomy in Men with Pathologically Organ-Confined Prostate Cancer
Authors: R.-Jüri Palisaar, Markus Graefen, Pierre I Karakiewicz, Peter G Hammerer, Edith Huland, Alexander Haese, Salvator Fernandez, Andreas Erbersdobler, Rolf-Peter Henke, Hartwig Huland
Journal: European Urology (2002)
The presence and longevity of peripherally expanded donor-derived TCRαβ+ mature T lymphocyte clones after allogeneic bone marrow transplantation for adult myeloid leukemias
Authors: H Saitoh, M Hirokawa, N Fujishima, Y Ichikawa, Y Kawabata, I Miura, A B Miura, T Matsutani, R Suzuki, K Sawada
Journal: Leukemia (2003)
Polio eradication--how near?
Authors: W. H. Foege
Journal: JAMA (1996)

There are rare occasions when a concerted effort may change history in a positive way forever. Eradicating poliomyelitis provides such an opportunity, and every person who has helped in getting a child immunized has participated. How is the world doing in the goal to achieve eradication? Do suggested changes in the US vaccination policy impede that objective? Are we providing sufficient protection to children in this country prior to global eradication?  See also p 1639.  The article by Chen et al 1 in this issue ofThe Journalprovides reassuring information on the protection of children in the United States. Levels of immunity in inner-city preschoolers were found to be high, consistent with national surveys that show immunization coverage to be the highest this country has ever achieved. 2 While the United States has often been criticized for lagging in immunization coverage of 2-year-old children, the real test of immunization
RADIUM TELETHERAPY: CLINICAL EXPERIENCE WITH A TEMPORARY "BOMB."
Authors: E. R. Carling, A. J. Leslie-Spinks
Journal: BMJ (1929)

BRexperilmlenitally to exist between the first two factors.Rose Bradford demonistrated that a dimiiinution in the amounlt of kidney substance led to an ineicase in the urine production by the remainingi tissue, and it can be slhown in the case of the isolated kidniey of the dog tllat functional riemoval of a paart of the kidney leads to in ilncreased flow of urine from the remainider, and that this increase in urine flowv is accompaniied by just those changes in coml)osition which occur when the perfusioni pressure to the kidney is r1aised.A diminution in the anatomical
Formoterol as needed with or without budesonide in patients with intermittent asthma and raised NO levels in exhaled air: a SOMA study
Authors: T. Haahtela, K. Tamminen, L. P. Malmberg, O. Zetterström, J. Karjalainen, H. Ylä-Outinen, T. Svahn, T. Ekström, O. Selroos
Journal: European Respiratory Journal (2006)

Patients with mild intermittent asthma sometimes show signs of inflammation, and guidelines suggesting bronchodilator therapy alone as needed may be questioned. The current study compared as-needed use of a rapid-acting beta2-agonist with as-needed use of a beta2-agonist and corticosteroid combination as the only medication in asthma patients with intermittent symptoms. A total of 92 nonsmoking asthma patients (of 187 screened) using only an inhaled beta2-agonist as needed (28 males, 64 females; mean age 37 yrs; mean forced expiratory volume in one second (FEV1) 101% predicted, mean reversibility 6.5% pred and fractional exhaled nitric oxide (FeNO) > or =20 parts per billion (ppb)) were randomised to treatment with formoterol (Oxis Turbuhaler) 4.5 microg as needed (n = 47) or budesonide/formoterol (Symbicort Turbuhaler) 160/4.5 microg as needed (n = 45) in a double-blind, parallel-group 24-week study. The primary variable of efficacy was change in FeNO. Baseline FeNO was 60 ppb and 59 ppb in the budesonide/formoterol and formoterol groups, respectively. Mean reductions in FeNO in the budesonide/formoterol and formoterol groups were 18.2 ppb and 2.8 ppb, respectively (95% confidence interval (CI) 7.5-23.5 ppb). The reduction in the budesonide/formoterol group occurred during the first 4 weeks of treatment and remained at this low level. Mean FEV1 increased by 1.8% pred normal value in the budesonide/formoterol group and decreased by 0.9% pred normal value in the formoterol group (95% CI -4.7- -0.7). In the budesonide/formoterol group, use of > or =4 inhalations x day(-1) of study medication was seen on 21 treatment days compared with 74 in the formoterol group. In conclusion, as-needed use of an inhaled corticosteroid together with a rapid-acting bronchodilator may be more beneficial than a beta2-agonist alone in patients with intermittent asthma and signs of airway inflammation. The long-term benefits are unknown.
Molecular dosimetry of aflatoxin exposure: contribution to understanding the multifactorial etiopathogenesis of primary hepatocellular carcinoma with particular reference to hepatitis B virus.
Authors: C P Wild, L A Jansen, L Cova, R Montesano
Journal: Environmental Health Perspectives (1993)

Aflatoxin exposure and hepatitis B virus infection have been implicated as major risk factors for primary hepatocellular carcinoma (PHC) in high-incidence regions of the world. Investigations using the assay of aflatoxin bound to peripheral blood albumin have shown that exposure can occur throughout the life span of the individual, including during the perinatal period, in high-incidence areas such as The Gambia, Senegal, Kenya, and The People's Republic of China. The possibility of measuring aflatoxin exposure at the individual level permits an investigation of the putative mechanisms of interaction of this carcinogen with HBV in the etiopathogenesis of PHC. Animal models, e.g., Pekin duck and HBV-transgenic mice, have also been used to study these questions, and the available data are reviewed.
Foreign body in the oesophagus.
Authors: E. E. Vella, P. J. Booth
Journal: BMJ (1965)

Children and infants are apt to swallow a multitude of articles, such as beads, buttons, hair, coins, toys, fruit stones, and so on.For the most part the swallowed objects, depending of course on their size and shape, pass through the alimentary tract and are excreted without causing undue harm to the patient; however, on occasion, even a smooth swallowed, object can be the cause of dire effects, as in the patient whose history is reported here. CASE REPORTEarly in the morning of Boxing Day 1964 a boy aged 2 years 3 months was admitted to the British Military Hospital, Munster, having just vomited approximately 1 pint (0.6 litres) of bright red blood.The only history given by the parents was that he had been off his food and miserable for one week.On examination the child had pale mucosae, a pulse rate of 120 per minute, and was apyrexial.Nothing abnormal was detected in the chest or abdomen.The results of laboratory tests were as follows: haemoglobin, 10 g./100 ml.; packed cell volume, 30%; white blood cell count, 17,000/c.mm.; platelets, 112,000/c.mm.While a possible diagnosis was being considered the parents said that they thought he had swallowed a 10-pfennig coin a week earlier.Radiography of the chest revealed a coin lodged at the level of the tracheal bifurcation.There was no evidence of air in the media- stinum (see Fig.).Blood transfusion was started, and oesophago- scopy was performed.The coin was found at approximately 20 cm.distance from the upper teeth, and was removed without difficulty and without causing bleeding.The coin measured 22 mm. in diameter and was discoloured to a dark green. (The German Federal Government coins of this value consist of a central iron core coated with an alloy of copper and zinc.)
AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications
Authors: C Grimaldi, F Chiarini, G Tabellini, F Ricci, P L Tazzari, M Battistelli, E Falcieri, R Bortul, F Melchionda, I Iacobucci, P Pagliaro, G Martinelli, A Pession, J T Barata, J A McCubrey, A M Martelli
Journal: Leukemia (2011)
Uterine Pathology in Women Undergoing Minimally Invasive Hysterectomy Using Morcellation
Authors: Jason D. Wright, Ana I. Tergas, William M. Burke, Rosa R. Cui, Cande V. Ananth, Ling Chen, Dawn L. Hershman
Journal: JAMA (2014)

While minimally invasive surgery has improved outcomes for hysterectomy, the procedure requires removal of the uterus through small incisions. Morcellation, or fragmentation of the uterus into smaller pieces, is one method to remove the uterus. Recently, concern has been raised that morcellation may result in the spread of undetected malignancies.1 Despite the commercial availability of electric power morcellators for 2 decades, accurate estimates of the prevalence of malignancy at the time of electric power morcellation (herein referred to as morcellation) are lacking,1,2 with single-center studies reporting prevalences from 9 to 100 in 10,000.3,4, We used a large insurance database to investigate the prevalence of underlying cancer in women who underwent uterine morcellation.
TCT-233 The Effects of Statin Therapy in Patients With ST-segment Elevation Myocardial Infarction According to Complete or Incomplete Revascularization
Authors: Hyun wook Lee, Shung Chull Chae, Inho Chae, Myeong Chan Cho, Yoon Jung Choi, Taek Jong Hong, Seung-Ho Hur, Yang soo Jang, Myung Ho Jeong, Jung Hwan Jo, Sang wook Kang, Ung Kim, Young Jo Kim, Tae hun Kwon, Chan Hee Lee, Sang Hee Lee, Jong Seon Park, Seung-Jung Park, Won Jong Park, Ki-Bae Seung, Dong Gu Shin, Jang Won Son, In Hwan Song, Junghan Yoon
Journal: Journal of the American College of Cardiology (2013)
853. Monitoring of Promoter-Controlled Adenoviral Replication with Noninvasive Imaging in Lung Cancer
Authors: Julia Davydova, Amy R. Nelson, Tatyana Gavrikova, Long P. Le, Hidetaka A. Ono, David T. Curiel, Masato Yamamoto
Journal: Molecular Therapy (2006)

The employment of conditionally replicative adenoviruses (CRAds) provides a novel way to treat lung cancer. To maintain safety and efficacy in clinical application, a noninvasive detection system of viral replication is required. However, there are currently no available methods to dynamically monitor adenovirus replication and spreading ability in clinical settings. Recently we have shown that the EGFP reporter gene placed in the deleted E3 region under the adenoviral major late promoter could be exploited to noninvasively monitor adenovirus replication.
HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse
Authors: Massimo F. Martelli, Mauro Di Ianni, Loredana Ruggeri, Franca Falzetti, Alessandra Carotti, Adelmo Terenzi, Antonio Pierini, Maria Speranza Massei, Lucia Amico, Elena Urbani, Beatrice Del Papa, Tiziana Zei, Roberta Iacucci Ostini, Debora Cecchini, Rita Tognellini, Yair Reisner, Franco Aversa, Brunangelo Falini, Andrea Velardi
Journal: Blood (2014)
Hemodynamic components of a cardiogenic hypertensive chemoreflex in dogs.
Authors: F Urthaler, G R Hageman, T N James
Journal: Circulation Research (1978)

The mechanical and hemodynamic components of a cardiogenic hypertensive chemoreflex were studied in 50 dogs. Within 6 seconds after a single injection of serotonin (100 microgram/ml) into the left atrium, mean pressure (mm Hg) rose in the aorta from 103 to 197 and in the pulmonary artery from 21 to 34. Left ventricular dp/dt virtually doubled. There was an increase (75%) in peripheral vascular resistance that returned to control within 10 seconds. There was no significant change in pulmonary vascular resistance. Aortic and pulmonary arterial hypertension were associated with a profound depression (82%) in atrial force. Atropine transformed this negative inotropic effect on the atria into a positive inotropic action that averaged 65%. In contrast, ventricular force was always sharply increased, more in the right (95%) than in the left ventricle (50%). Bilateral stellectomy did not eliminate the reflex but it completely abolished the initial increase of cardiac contractility; a delayed increase in contractility persisted and was due exclusively to release of catecholamines from the adrenal glands. This cardiogenic hypertensive chemoreflex uses the vagus for its afferent neural traffic and both the sympathetic and the vagus nerves for its efferent route. The brief and intense systemic vasoconstriction concomitant with an increase in cardiac contractility might represent a kind of "aortic cough." Some possible clinical implications are discussed.
Sci-Mate Universal Online Searcher Bibliofile
Authors: ROBERT S WIGTON
Journal: Annals of Internal Medicine (1984)

Software1 April 1984Sci-Mate Universal Online SearcherBibliofileROBERT S WIGTON, M.D.ROBERT S WIGTON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-4-621 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptComputers have dramatically increased our access to the medical literature. Most of the world's literature can be searched in seconds and retrieved through the expanding nationwide telecommunications network. This enhanced capacity has brought with it problems of complicated access protocols and large volumes of information of low utility. Here are three microcomputer programs designed to help us with the expanding bibliographic database.Sci-Mate's Universal Online Searcher is a telecommunications program that translates search requests into the specialized language of a database. Using your external modem, the program dials the network, transmits the necessary access codes, and then asks for your... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Nebraska Medical Center Omaha, Nebraska PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byComputerized personal information systems for research scientistsA bibliography of text information management software for IBM microcomputers and compatiblesManaging bibliographic citations using microcomputersReview of Sci-Mate™EUGENE GARFIELD, PH.D., CATHERYNE STOUT, M.S.I.S.Authorship for SoftwareJAMES A. COWAN, M.D. 1 April 1984Volume 100, Issue 4Page: 621-622KeywordsComputersDatabases ePublished: 1 December 2008 Issue Published: 1 April 1984 PDF downloadLoading ...
Hereditary antithrombin iii deficiency and thromboembolic disease
Authors: Donald J. Filip, John D. Eckstein, Jan J. Veltkamp
Journal: American Journal of Hematology (1976)

Abstract Two teenage brothers with recurrent thromboembolic disease were found to have antithrombin III deficiency. A family study spanning four generations revealed a total of 10 members with antithrombin III deficiency. Five of the 10 affected family members have had thrombotic problems. Antithrombin III deficiency was documented by coagulation assays measuring heparin cofactor, anti‐Factor Xa, and progressive antithrombin activity; the level of antithrombin III antigenic material measured by immunoelectrophoresis was low in subjects with abnormal coagulation assays. The clinical features which may lead one to suspect the hereditary hypercoagulable condition of antithrombin III deficiency are reviewed.
ANTIPROTEINS IN HORSE SERA
Authors: Henry P. Treffers, Michael Heidelberger, Jules Freund
Journal: The Journal of Experimental Medicine (1947)

1. The intravenous injection of two horses with alum-precipitated rabbit serum globulin resulted in the production of antibody which gave a typical precipitin reaction without a prezone in the region of antibody excess. 2. The chemical, physical, and serological properties of this antibody are comparable to those of the more familiar anticarbohydrate antibodies. 3. The subcutaneous injection of horses with the globulin antigen gave rise to low grade "univalent" antibody which did not precipitate with soluble antigen. 4. The low grade antibody could be removed from solution by attachment to preformed specific precipitates, or by coprecipitation in the presence of "multivalent" precipitating antibody. 5. It is concluded that the familiar antitoxin type of antibody is not the only form of antiprotein response in horses but that precipitating and low grade non-precipitating antibodies may also be formed. 6. The nature of the antigen and the route of injection are demonstrated to be important factors in determining the characteristics of the antibody formed.
Role of interleukin 10 in norfloxacin prevention of luminal free endotoxin translocation in mice with cirrhosis
Authors: Isabel Gómez-Hurtado, Alba Moratalla, Ángela Moya-Pérez, Gloria Peiró, Pedro Zapater, José M González-Navajas, Paula Giménez, José Such, Yolanda Sanz, Rubén Francés
Journal: Journal of Hepatology (2014)
Synergistic antitumor activity of lenalidomide with the BET bromodomain inhibitor CPI203 in bortezomib-resistant mantle cell lymphoma
Authors: A Moros, V Rodríguez, I Saborit-Villarroya, A Montraveta, P Balsas, P Sandy, A Martínez, A Wiestner, E Normant, E Campo, P Pérez-Galán, D Colomer, G Roué
Journal: Leukemia (2014)
Charity did not break law in giving information about late abortions
Authors: Clare Dyer
Journal: BMJ (2005)

A leading British provider of abortions did not break the law when it told women who wanted late terminations about a clinic in Spain that would perform them, a report by Liam Donaldson, the chief medical officer for England, concluded last week.

Professor Donaldson investigated the charity the British Pregnancy Advisory Service (BPAS) after a newspaper reported that it was illegally referring women to Spain for abortions after 24 weeks' gestation, the limit in Britain for abortions for “social” reasons.

Professor Donaldson has decided that BPAS did not break the law by telling women about the Spanish …
A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men
Authors: Elise A. Olsen, Frank E. Dunlap, Toni Funicella, Judith A. Koperski, James M. Swinehart, Eduardo H. Tschen, Ronald J. Trancik
Journal: Journal of the American Academy of Dermatology (2002)
THE ORGANIZATION OF THE TREATMENT OF FRACTURES
Authors: E. W. H. Groves
Journal: BMJ (1935)

<h3>Abstract</h3> Three of the five currently recognized “<i>Candidatus</i> Liberibacter” spp., “<i>Ca</i>. L. asiaticus” (Las), “<i>Ca</i>. L. americanus” (Lam) and “<i>Ca</i>. L. solanacearum”, and the newly erected genus <i>Liberibacter</i> species, L. <i>crescens</i> (Lcr), have had their genomes sequenced. In all four cases there are three homogeneous copies of the 16S rRNA gene, one present as the reverse complement of the other two. 16S intragenic homogeneity is common within the α-Proteobacteria. The presence of three 16S rRNA copies indicates an advantage for a rapid response of population increase to favourable growth conditions. The metabolic cost of carrying multiple copies is avoided during periods of low cellular activity as this situation occurs at low temperatures, for example overwintering in deciduous plants or in a dormant insect host. A large insertion in the 16S rDNA sequence of three species compared to the other three species indicates a dichotomy in the <i>Liberibacter</i> genus and provides a phylogenetic signal of closeness to the proximal node within the Rhizobiaceae. In spite of similar symptoms in <i>Citrus</i> crops associated with Lam and Las infections, these species belong on either side of this dichotomy, thus confirming Lam as phylogenetically closer to the proximal node than Las.
Prenatal Exposure to Organophosphate Pesticides and IQ in 7-Year-Old Children
Authors: Maryse F. Bouchard, Jonathan Chevrier, Kim G. Harley, Katherine Kogut, Michelle Vedar, Norma Calderon, Celina Trujillo, Caroline Johnson, Asa Bradman, Dana Boyd Barr, Brenda Eskenazi
Journal: Environmental Health Perspectives (2011)

Organophosphate (OP) pesticides are neurotoxic at high doses. Few studies have examined whether chronic exposure at lower levels could adversely affect children's cognitive development.We examined associations between prenatal and postnatal exposure to OP pesticides and cognitive abilities in school-age children.We conducted a birth cohort study (Center for the Health Assessment of Mothers and Children of Salinas study) among predominantly Latino farmworker families from an agricultural community in California. We assessed exposure to OP pesticides by measuring dialkyl phosphate (DAP) metabolites in urine collected during pregnancy and from children at 6 months and 1, 2, 3.5, and 5 years of age. We administered the Wechsler Intelligence Scale for Children, 4th edition, to 329 children 7 years of age. Analyses were adjusted for maternal education and intelligence, Home Observation for Measurement of the Environment score, and language of cognitive assessment.Urinary DAP concentrations measured during the first and second half of pregnancy had similar relations to cognitive scores, so we used the average of concentrations measured during pregnancy in further analyses. Averaged maternal DAP concentrations were associated with poorer scores for Working Memory, Processing Speed, Verbal Comprehension, Perceptual Reasoning, and Full-Scale intelligence quotient (IQ). Children in the highest quintile of maternal DAP concentrations had an average deficit of 7.0 IQ points compared with those in the lowest quintile. However, children's urinary DAP concentrations were not consistently associated with cognitive scores.Prenatal but not postnatal urinary DAP concentrations were associated with poorer intellectual development in 7-year-old children. Maternal urinary DAP concentrations in the present study were higher but nonetheless within the range of levels measured in the general U.S. population.
Acute Spinal-Cord Injury
Authors: Michael D. Walker
Journal: New England Journal of Medicine (1991)

Acute spinal-cord injury is an unexpected, catastrophic event, the consequences of which often persist for the life of the patient and influence in diverse ways not only the patient, but also family members and society at large. The incidence of acute spinal-cord injury in the United States is about 10,000 per year. Less than 10 percent of these patients die of the acute injury, whereas 720 per million of the population are disabled as a result of such injuries; 80 percent are young men in what should be the prime productive years of their lives. The initial costs of hospitalization . . .
Preservation of endothelium-dependent vascular relaxation in cholesterol-fed rabbit by treatment with the calcium blocker PN 200110.
Authors: J B Habib, C Bossaller, S Wells, C Williams, J D Morrisett, P D Henry
Journal: Circulation Research (1986)

We tested the effects of low doses of a dihydropyridine calcium antagonist, PN 200110, on endothelium-dependent vascular relaxation in rabbits fed a 1% cholesterol diet. The drug was given orally, 1 mg/day, and control rabbits received placebo. Plasma total cholesterol after 10 weeks, was similar in the placebo- and PN 200110-treated groups. The respective values averaged 2140 +/- 116 (n = 14; mean +/- SEM) and 2012 +/- 115 mg/dl (n = 13). In placebo-treated rabbits, sudanophilic aortic lesions covered 52 +/- 5% of the intimal surface, and the aortic cholesterol concentration was 72 +/- 6 mg/g protein. Corresponding values in aortas from PN 200110-treated rabbits were significantly lower [36 +/- 5% (P less than 0.03) and 52 +/- 3 mg/g protein (P less than 0.03)]. Maximal endothelium-dependent cholinergic relaxation of aortic strips in untreated (n = 14) and treated cholesterol-fed rabbits (n = 13) differed significantly (P less than 0.01) and averaged 31 +/- 4% and 61 +/- 7% of the value in normocholesterolemic controls (n = 13). We conclude that cholesterol feeding suppresses endothelium-dependent relaxation evoked by acetylcholine, and that PN 200110 reduces the severity of atherosclerosis and impairment of endothelium-dependent relaxation.