Update in Pulmonary Medicine: Evidence Published in 2014
Authors: Jess Mandel
Journal: Annals of Internal Medicine (2015)

Updates5 May 2015Update in Pulmonary Medicine: Evidence Published in 2014Jess Mandel, MDJess Mandel, MDFrom the University of California, San Diego, School of Medicine, San Diego, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-0262 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This article summarizes important studies published in 2014 that have the potential to substantially influence the practice of pulmonary and internal medicine. Key studies were identified from ACP Journal Club and ACP JournalWise and were some of the most frequently accessed and highest-ranked articles in 2014. Beneficial therapies were reported for idiopathic pulmonary fibrosis, a disease that heretofore has eluded effective therapy. A monoclonal antibody–based therapy may substantially benefit a select group of patients with severe asthma refractory to traditional therapies. Another trial demonstrated that inhaled corticosteroids may be withdrawn from the treatment of some patients with stable chronic obstructive ...References1. Ahluwalia N, Shea BS, Tager AM. New therapeutic targets in idiopathic pulmonary fibrosis. Aiming to rein in runaway wound-healing responses. Am J Respir Crit Care Med. 2014;190:867-78. [PMID: 25090037] doi:10.1164/rccm.201403-0509PP CrossrefMedlineGoogle Scholar2. George TJ, Arnaoutakis GJ, Shah AS. Lung transplant in idiopathic pulmonary fibrosis. Arch Surg. 2011;146:1204-9. [PMID: 22006881] doi:10.1001/archsurg.2011.239 CrossrefMedlineGoogle Scholar3. Lötvall J, Akdis CA, Bacharier LB, Bjermer L, Casale TB, Custovic A, et al. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol. 2011;127:355-60. 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[PMID: 22371849] doi:10.7326/0003-4819-156-7-201204030-00411 LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Jess Mandel, MDAffiliations: From the University of California, San Diego, School of Medicine, San Diego, California.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M15-0262.Corresponding Author: Jess Mandel, MD, Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, Mail Code 0606, La Jolla, CA 92093; e-mail, jmandel@ucsd.edu.Author Contributions: Conception and design: J. Mandel.Analysis and interpretation of the data: J. Mandel.Drafting of the article: J. Mandel.Critical revision of the article for important intellectual content: J. Mandel.Final approval of the article: J. Mandel.Administrative, technical, or logistic support: J. Mandel.Collection and assembly of data: J. Mandel.This article was published online first at www.annals.org on 30 April 2015. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 5 May 2015Volume 162, Issue 9Page: W117-W121KeywordsAsthmaEdemaForced vital capacityGlucocorticoid therapyInterstitial lung diseasesLung and intrathoracic tumorsLungsMortalityRandomized trialsUltrasound imaging ePublished: 5 May 2015 Issue Published: 5 May 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...