tbuckley/cabot-search huggingface dataset:
Professionalism in Medicine: Critical Perspectives
Authors: Mark J. DiNubile
Journal: Annals of Internal Medicine (2008)

Medical Writings: Book Notes6 May 2008Professionalism in Medicine: Critical PerspectivesMark J. DiNubile, MDMark J. DiNubile, MDFrom Merck Research Laboratories, West Point, Pennsylvania.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-9-200805060-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Professionalism in Medicine: Critical PerspectivesWear D, Aultman JM, eds. 276 pages. New York: Springer; 2006. $99.00. ISBN 9780387327266. Order at www.springer.com.Field of medicine: Medical education and ethics.Format: Hardcover book.Audience: Health care educators, medical ethicists, clinicians, and medical students.Purpose: To articulate the parameters of professional behavior for health care providers from different perspectives, while challenging the status quo.Content: The essence of medical professionalism has gradually emigrated from a self-evident code of conduct to a topic fueling heated debate. Like other contentious issues, professionalism remains hard to explicitly define, but most physicians would state that they ... Author, Article, and Disclosure InformationAffiliations: From Merck Research Laboratories, West Point, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 6 May 2008Volume 148, Issue 9Page: 716KeywordsBehaviorBioethicsHealth careHealth care providersMedical educationResearch laboratoriesSoftware tools ePublished: 6 May 2008 Issue Published: 6 May 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Drug Solubility: Mesoporous Calcium Carbonate as a Phase Stabilizer of Amorphous Celecoxib - An Approach to Increase the Bioavailability of Poorly Soluble Pharmaceutical Substances (Adv. Healthcare Mater. 11/2013)
Authors: Johan Forsgren, Mattias Andersson, Peter Nilsson, Albert Mihranyan
Journal: Advanced Healthcare Materials (2013)

On page 1469, Johan Forsgren, Albert Mihranyan, and co-workers show how vaterite is used as a phase stabilizer of amorphous celecoxib, resulting in the increase of the apparent aqueous solubility of the substance. The presented results show promise for the use of vaterite to achieve enhanced bioavailability in new formulations of Type II BCS drugs.
Abstract 17922: Long-term Mortality After Cardiovascular Implantable Electronic Device Infection
Authors: Madhu Reddy, Jenna Chaung, Hemant Boolani, Wissam Atrouni, Donita Atkins, Sudharani Bommana, Rhea Pimentel, Martin Emert, Loren Berenbom, James Vacek, Dhanunjaya Lakkireddy, Raghuveer Dendi
Journal: Circulation (2012)

Background: There is limited data available on the incidence and predictors of long-term mortality of cardiovascular-implantable electronic device (CIED) infections Methods: We evaluated the incidence and predictors of long-term mortality after CIED infections in a large academic center. Baseline characteristics, clinical presentation and treatment variables were collected. Mortality data was collected from medical records and social security death index. Results: Between 2005 and 2011, 118 patients with CIED infections were referred to our institute and are included in the study. Mean age was 69±15years with 78% males. Pacemaker, implantable defibrillator and cardiac resynchronization therapy-defibrillators were infected in 42%, 23% and 36% of the patients respectively. Patients were admitted with CIED infection after a median duration of 5 months from the last device procedure. Infective endocarditis (IE) defined with modified Duke criteria (positive blood cultures and vegetation on imaging) was seen in...
Medical Consequences of Alcoholism
Authors: KENNETH H. WILLIAMS
Journal: Annals of Internal Medicine (1974)

Symposium1 August 1974Medical Consequences of AlcoholismKENNETH H. WILLIAMS, M.D.KENNETH H. WILLIAMS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-2-265 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStimulated in part by increased federal funding, research into the medical aspects of alcoholism has progressed prodigiously in the past few years. Although the education of physicians on alcoholism has been scanty at best, this explosion of information has further widened the gap of knowledge between what is known and what is practiced. The recent symposium, "The Medical Consequences of Alcoholism," The Fifth Annual Medical-Scientific Session, sponsored by the National Council on Alcoholism, presented important information that should be useful to every practitioner who is attempting to treat patients with this widespread affliction.Within minutes after ingestion, the small ethyl...References1. DEMAKISPROSKEYPAHIMTOOLA JAS: The natural course of alcoholic cardiomyopathy. Ann Intern Med 80:293-297, 1974 LinkGoogle Scholar2. REGAN T: Cardiac toxicity of ethyl alcohol. Alcohol Health and Research World Winter 1973/74, pp. 23-28 Google Scholar3. ROSENBERG C: Drug maintenance in the outpatient treatment of chronic alcoholism. Arch Gen Psychiatry 30:373-377, 1974 CrossrefMedlineGoogle Scholar4. KALES A: Chronic hypnotic-drug use, ineffectiveness, drug-withdrawal insomnia and dependence. JAMA 227:513-517, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Western Psychiatric Institute and Clinic University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Structure of Drinking-Related Consequences in Alcoholic WomenA 1 August 1974Volume 81, Issue 2Page: 265-265KeywordsAlcoholismIngestionResearch funding Issue Published: 1 August 1974 PDF downloadLoading ...
Prognostic significance of Fas (CD95/APO‐1) positivity in patients with primary nodal diffuse large B‐cell lymphoma
Authors: Bulent Eser, Ismail Sari, Ozlem Canoz, Fevzi Altuntas, Erol Cakmak, Ahmet Ozturk, Metin Ozkan, Ozlem Er, Mustafa Cetin, Ali Unal
Journal: American Journal of Hematology (2006)

Fas (CD95/APO-1) is a protein that is mainly related to apoptosis of lymphoid cells. The increment of Fas expression is associated with long-term survival in various malignancies. However, there are limited studies regarding the effect of Fas expression on the course and prognosis of non-Hodgkin's lymphoma. The aim of this study was to investigate the significance of immunohistochemical Fas expression on the prognosis of nodal diffuse large B-cell lymphoma. A total of 63 patients with primary nodal diffuse large B-cell lymphoma diagnosed in the Erciyes University Department of Hematology between 1990 and 2003 were included in the study. The median age of the patients was 55 years old (range 19-102 years old). The median follow-up period was 19 months (2-132 months). Histopathological sections were stained immunohistochemically and evaluated by light microscopy for Fas, bcl-2, and p53. Clinical and laboratory parameters including Fas, bcl-2, and p53 positivity, age, sex, performance status, clinical stage, presence of B symptoms, bone marrow involvement, extranodal involvement, and lactic dehydrogenase levels were evaluated to compare overall survival. Complete remission was obtained in 28 patients (44.4%) after first-line chemotherapy. Fas positivity, male gender, good performance status, clinical stage I-II, absence of B symptoms, normal lactic dehydrogenase value, and absence of bone marrow involvement were favorable prognostic factors for complete remission in statistical analysis. Multivariate analysis revealed that positive Fas expression and ECOG performance status were independent prognostic factors for overall survival. Also, Fas-positive patients had significantly prolonged progression-free survival. Immunohistochemical Fas positivity was a favorable prognostic factor for complete remission and overall and progression-free survival in primary nodal diffuse large B-cell lymphoma.
Gaucher Cells in Pulmonary-Capillary Blood in Association with Pulmonary Hypertension
Authors: David J. Ross, Susanne Spira, Neil A. Buchbinder
Journal: New England Journal of Medicine (1997)

To the Editor: Although pulmonary involvement in adult-type Gaucher's disease (type 1) is unusual, as compared with the infantile type (type 2), previous reports have described aggregations of Gauc...
Chronic Stress and the Heart
Authors: Janet M. Torpy, Cassio Lynm, Richard M. Glass
Journal: JAMA (2007)

Chronic Stress and the Heart Emotional and physical stresses have a negative impact on the heart and the vascular system.Acute stress happens all at once; chronic stress occurs over a longer time period.Stress hormones (catecholamines, including epinephrine, which is also known as adrenaline) have damaging effects if the heart is exposed to elevated catecholamine levels for a long time.Stress can cause increased oxygen demand on the body, spasm of the coronary (heart) blood vessels, and electrical instability in the heart' s conduction system.Chronic stress has been shown to increase the heart rate and blood pressure, making the heart work harder to produce the blood flow needed for bodily functions.Long-term elevations in blood pressure, also seen with essential hypertension (high blood pressure not related to stress), are harmful and can lead to myocardial infarction (heart attack), heart failure, abnormal heart rhythms, and stroke.The October 10, 2007, issue of JAMA contains an article about the effects of chronic job stress on the heart and the cardiovascular system.
...and living wills
Authors: A. Paton
Journal: BMJ (1995)

In “Whose Death is it Anyway?” the histories of four living patients were selected to develop the thesis that advance directives (living wills) are, in the view of the caring and thoughtful Dr Christina Williams of the Royal Hospital for Neuro-Disability, “potentially dangerous …as presently envisaged.”

Christine Darley-Jones (46) had been a bright and successful city executive until a medical accident during a minor operation left her brain damaged, doubly incontinent, totally dependent, and fed by stomach tube. Eight months …
Governance Plan Paves Way for Search for JAMA Editor
Authors: Mike Mitka
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnosis of Gastroesophageal Reflux Disease in General Practice: A Belgian National Survey
Authors: P. Eisendrath, J. Tack, J. Devière
Journal: Endoscopy (2002)

Background and Study Aims: The aim of the present study was to analyze the results of a prospective national survey conducted in Belgium to investigate discrepancies between general practitioners’ attitudes and the available guidelines on the management of new patients with symptoms of gastroesophageal reflux disease (GERD). Methods: A total of 641 general practitioners (GPs) were asked to complete a questionnaire on each consultation by a patient with suspected GERD. Results: The study population included 2234 patients (mean age ± SD: 47.37 ± 16.23 years; 52 % aged 45 or older) consulting for the first time for GERD symptoms, without previous endoscopy. Symptoms were classified as mild, moderate, or severe in 39.5 %, 48.0 %, and 11.3 % respectively, and as typical, atypical, or ”alarm“ in 87.5 %, 16.8 %, and 10.5 % respectively. Upper gastrointestinal endoscopy was requested by GPs in 24.7 % of patients (553 of 2234; including 186 cases that were not justified according to the guidelines), while it should have been requested in 56.6 % (1266 of 2234) if the GPs had respected the national guidelines. Only 28.4 % of the 1171 patients aged 45 or older and 52.6 % of the 95 patients under 45 presenting with alarm symptoms had an endoscopy requested at the first visit. A stepwise multiple logistic regression analysis showed that anemia and symptom severity were the two main factors prompting the GPs to request endoscopy for these patients. Conclusions: There are major discrepancies between GP practice and national or international guidelines for GERD diagnosis. GPs clearly underused endoscopy in patients with alarm symptoms of GERD and in older patients with a new onset of GERD symptoms. GPs are more strongly influenced by the severity of symptoms than by the type of symptoms.
THE USE OF RADIOACTIVE LYSINE IN STUDIES OF PROTEIN METABOLISM
Authors: L. L. Miller, W. F. Bale, C. L. Yuile, R. E. Masters, G. H. Tishkoff, G. H. Whipple
Journal: The Journal of Experimental Medicine (1949)

Racemic lysine labeled with C(14) in the epsilon carbon position was fed to dogs. The distribution of C(14) in blood and tissue fractions is recorded. In normal dogs sacrificed at 24 hours, approximately one-third of the C(14) was found in the urine, one-third in expired air, and one-third in the body, mostly in protein, predomantly as lysine residues. The rate of C(14) excretion as CO(2), hour by hour, paralleled closely the amount of non-protein C(14) in the blood plasma. The liver, kidney, pancreas, and spleen all have high values for C(14) in 24 hour and 17 day experiments. The gastrointestinal tract is significantly high in the 24 hour experiments. Plasma protein from animals previously fed C(14) containing lysine and thus in turn labeled, was transfused into other dogs and the rate of disappearance of albumin and globulin fractions from the circulation of the recipient dog followed. The results lead to the conclusion that as a whole, plasma proteins are utilized and replaced at a rate of at least 10 per cent per 24 hours. This minimum rate is substantially faster than turnover rates commonly accepted and emphasizes the rôle played by the plasma proteins in the protein economy of the body. The exact rate determination is made uncertain by the lack of knowledge of the magnitude of the amount of protein in solution in extracellular and lymph spaces and its rate of equilibrium with circulating plasma proteins. Evidence from these transfusion studies indicates that plasma globulin is metabolized at a significantly faster rate than plasma albumin. This is confirmed by the observation that following the feeding of labeled lysine to dogs, C(14) is first incorporated in globulin in high concentration but that later it also disappears more rapidly from the globulin fraction. These data suggest that the period of bone marrow maturation of the red cell during which time its related hemoglobin is synthesized does not exceed 3 to 5 days.
Diagnosis of monoclonal gammopathy of renal significance
Authors: Frank Bridoux, Nelson Leung, Colin A. Hutchison, Guy Touchard, Sanjeev Sethi, Jean-Paul Fermand, Maria M. Picken, Guillermo A. Herrera, Efstathios Kastritis, Giampaolo Merlini, Murielle Roussel, Fernando C. Fervenza, Angela Dispenzieri, Robert A. Kyle, Samih H. Nasr
Journal: Kidney International (2015)
Gluten specific suppressor T cell dysfunction in coeliac disease.
Authors: G R Corazza, P Sarchielli, M Londei, M Frisoni, G Gasbarrini
Journal: Gut (1986)

A T lymphocyte direct migration inhibition factor test has been used to investigate the function of the specific suppressor T cell population controlling the immune response to gluten in coeliac disease. The test has been carried out in 21 adult coeliac patients, 22 Mantoux- healthy controls and eight Mantoux+ donors using gluten fraction III and purified protein derivative, as antigens. All coeliacs, but two, were Mantoux-. When gluten fraction III was used a significant migration inhibition was observed in coeliac patients compared to controls; such migration inhibition was abrogated by coculturing in a 1:1 ratio coeliac T cells with T cells from controls or Mantoux+ donors. On the contrary, the addition to coeliac T cells of T lymphocytes from other coeliacs did not abolish migration inhibition to gluten. Pretreatment of normal T cells with mitomycin C prevented their abrogating activity on migration inhibition of coeliac T lymphocytes. When purified protein derivative was used as antigen a significant migration inhibition was observed in Mantoux+ donors compared with healthy subjects and such migration inhibition was abolished by co-culturing T cells from Mantoux+ donors with those from Mantoux- controls and coeliac patients. Our results show that coeliac T cells, while retaining their ability to suppress the immune response to purified protein derivative, cannot suppress the immune response to gluten and are consistent with the hypothesis that a gluten specific suppressor T cell dysfunction, rather than a generalised T lymphocyte defect, may play a role in the pathogenesis of coeliac disease.
Case-control study in basal cell carcinoma of the skin: single nucleotide polymorphisms in three interleukin promoters pre-analysed in pooled DNA
Authors: S. Wilkening, K. Hemminki, P. Rudnai, E. Gurzau, K. Koppova, R. Kumar, A. Försti
Journal: British Journal of Dermatology (2006)

Basal cell carcinoma (BCC) is one of the most common neoplasms in the world. Development of BCC is associated with environmental factors (especially sun exposure) as well as heritable factors.To analyse three single nucleotide polymorphisms (SNPs) in the promoter regions of interleukin (IL) genes in genomic DNA from 527 cases of BCC and 530 matched controls and to examine if DNA pooling is a useful method on which to base decisions regarding further SNP analysis.The SNPs analysed were IL6-597, IL10-1082 and IL1B-511. The SNPs were first analysed from pooled DNA and afterwards from individual samples. The DNA pools resulted from a division of the samples into cases and controls, female and male, and three age groups. In these pools the allele frequencies were estimated by two methods, real-time polymerase chain reaction with allele-specific primers, and quantitative sequencing.No significant association was found when the allele frequencies in cases and controls were compared. However, by analysis of the individual genotypes we found SNP IL6-597 G/A to be significantly associated with BCC risk (P =0.007). Hereby the heterozygous genotype 'GA' had a protective effect (odds ratio 0.64, 95% confidence interval 0.49-0.84). No significant association was found for IL10-1082 and IL1B-511.The association of SNP IL6-597 with BCC could be found only by individual genotyping, but would have been missed if only data from the pooling analysis had been known.
Circulating DNA:anti-DNA complexes in systemic lupus erythematosus. Detection and characterization by ultracentrifugation.
Authors: C Bruneau, J Benveniste
Journal: Journal of Clinical Investigation (1979)

Although it is generally accepted that DNA:anti-DNA immune complexes play a significant role in the pathogenesis of tissue injury in systemic lupus erythematosus, their presence in the circulation is still a matter of controversy. In this study, we detected DNA:anti-DNA compexes by identification of both the antigen and(or) the antibody, the necessary requisites for immune complex definition, in 14 of 24 plasmas (7 of 11 patients). These antibodies were specific for native DNA and could be adsorbed by anti-immunoglobulin (Ig)G antisera. The DNA recovered was, at least in part, of low molecular weight. The presence of DNA:anti-DNA compexes was not related to high molecular weight IgG, cryoprecipitins, positive polyethylene glycol precipitation, or low plasma C3 levels. It was related significantly to low plasma C4 levels and to the presence of diffuse proliferative nephritis. The lack of correlation with other methods of detection of immune complexes and with the presence of heavy IgG (above 13 S) is in favor of the existence of other antigen-antibody systems (or aggregated immunoglobulins) in systemic lupus erythematosus plasmas. From the results, it appears that methods directed towards the demonstration of specific immune complexes are more informative than those detecting heavy or altered immunoglobulins.
Internal Medicine: An Illustrated Radiological Guide
Authors: Leonard Berlin
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A MODIFICATION OF THE MURPHY BUTTON.
Authors: ARTHUR E. HERTZLER
Journal: JAMA (1898)

The time required to suture the ends of the intestines, and the necessity of pushing in the suture threads after tying the plates, and the uncertainty of an adequate opening, in the use of the decalcified bone plates of Professor Senn; the large size of the body to be extruded, the danger of lodgment and the occasional undue pressure of the spring, in the Murphy button; the time required to make a union by the Czerny-Lembert suture, seem a sufficient apology for continued investigation in the perfecting of a method for uniting the various parts of a digestive tract in case of disease or injury. That many advances along this line have been made is evident, and it is equally obvious that there is still room for improvement. It is with the hope of contributing to this advancement that this modification of existing methods is offered. The present combination is