tbuckley/cabot-search huggingface dataset:
Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia
Authors: Lise Willems, Nathalie Jacque, Arnaud Jacquel, Nathalie Neveux, Thiago Trovati Maciel, Mireille Lambert, Alain Schmitt, Laury Poulain, Alexa S. Green, Madalina Uzunov, Olivier Kosmider, Isabelle Radford-Weiss, Ivan Cruz Moura, Patrick Auberger, Norbert Ifrah, Valérie Bardet, Nicolas Chapuis, Catherine Lacombe, Patrick Mayeux, Jérôme Tamburini, Didier Bouscary
Journal: Blood (2013)
Coronary Angioplasty Procedure Volume and Major Complications-Reply
Authors: Stephen E. Kimmel
Journal: JAMA (1996)

<h3>In Reply.</h3> —We appreciate the updated information provided by Dr Phillips and colleagues<sup>1</sup>concerning the results of their multivariate-adjusted analyses. Their report lends further support to the procedure volume—complication relationship for percutaneous ballon angioplasty procedures. We agree that their use of administrative data did not allow for adjustment for the range of clinical variables available in our study. Nonetheless, it is interesting that, similar to our findings, Phillips and colleagues found that centers with higher procedure volume (in their study, &gt;500 PTCAs) had significantly lower than predicted adverse outcomes for patients without a principal diagnosis of AMI. The fact that their results for hospitals performing fewer than 200 PTCAs per year differed from ours certainly could have been attributable to differences in the source of hospitals used in these studies, differences in outcome definitions, or even differences in the effects of geographical and health care market forces on the
Polypharmacy in Skilled-Nursing Facilities
Authors: Martin Terplan
Journal: Annals of Internal Medicine (1993)

Letters15 April 1993Polypharmacy in Skilled-Nursing FacilitiesMartin Terplan, MDMartin Terplan, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-118-8-199304150-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The recent article by Beers and coworkers [1] and the accompanying editorial by Jones [2] illustrate a disturbing trend in data reporting and, more subtly, in patient care. Adopting predetermined criteria for inappropriate medication prescribing and then using a computer print-out of a physician order sheet certainly simplify a study. But how do investigators know whether any of the numerous drugs were beneficial or harmful? Studying computer print-outs rather than patients raises serious concerns.Furthermore, neither the investigator nor the editorialist commented that, on average, each nursing home resident had 7.2 medications ordered! Because these patients are ...References1. Beers MH, Ouslander JG, Fingold SF, Morganstern H, Reuben DB, Rogers W, et al. Inappropriate medication prescribing in skilled-nursing facilities. Ann Intern Med. 1992; 117:684-9. Google Scholar2. Jones JK. Assessing potential risk of drugs: the elusive target. Ann Intern Med. 1992; 117:691-2. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 April 1993Volume 118, Issue 8Page: 649-651KeywordsBeerComputersDrugsHealth careNursing homesPatientsPharmacistsResearch design ePublished: 15 August 2000 Issue Published: 15 April 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
THE DIAGNOSTIC VALUE OF GASTRIC FRACTIONAL TEST MEALS
Authors: H. S. Pemberton
Journal: BMJ (1922)

THE following remarks are based on the examination of over two hundred fractional test meals undertaken durina the last fifteen montlhs.Nearly all these meals were withdrawn from patients presenting either symptoms or physical signs pointing to an abdominal lesion; other cases included persons thouglht to be normal and a few patients in whom tlle condition was de fnitely extra-abdominal.The meal employed was that recommended by Ryle,1 withdrawn by means of a Relhfuss tube; the material witlh- drawn was filtered, and (in the filtrate) estimations of total acidity and of free hydrochloric acid were made by the Topfer method.If the presence of bile was obvious searchl was made for it with the aid of acetone and hitric acid; microscopic examination both of the unfiltered gastric residaum and of tlhe neal was also carried out.In a number of cases tlle chloride content was estimated by the Volhard-Arnold method and hydrogen-ion concentration determined by tlhe use of indicators.Correlation was also made, whenever possible, witlh clinical, radiographic, and verified findings.Before setting out the actual findiugs, which are largely confirmatory of thie work of others, it will perhaps be permissible to consider some points in relation to gastric secre- tion.Various views are lheld mn the association between
Activation-induced Modification in the CD3 Complex of the γδ T Cell Receptor
Authors: Sandra M. Hayes, Karen Laky, Dalal El-Khoury, Dietmar J. Kappes, B.J. Fowlkes, Paul E. Love
Journal: The Journal of Experimental Medicine (2002)

The T cell antigen receptor complexes expressed on αβ and γδ T cells differ not only in their respective clonotypic heterodimers but also in the subunit composition of their CD3 complexes. The γδ T cell receptors (TCRs) expressed on ex vivo γδ T cells lack CD3δ, whereas αβ TCRs contain CD3δ. While this result correlates with the phenotype of CD3δ−/− mice, in which γδ T cell development is unaffected, it is inconsistent with the results of previous studies reporting that CD3δ is a component of the γδ TCR. Since earlier studies examined the subunit composition of γδ TCRs expressed on activated and expanded peripheral γδ T cells or γδ TCR+ intestinal intraepithelial lymphocytes, we hypothesized that activation and expansion may lead to changes in the CD3 subunit composition of the γδ TCR. Here, we report that activation and expansion do in fact result in the inclusion of a protein, comparable in mass and mobility to CD3δ, in the γδ TCR. Further analyses revealed that this protein is not CD3δ, but instead is a differentially glycosylated form of CD3γ. These results provide further evidence for a major difference in the subunit composition of αβ- and γδ TCR complexes and raise the possibility that modification of CD3γ may have important functional consequences in activated γδ T cells.
Expression of cysteinyl leukotriene (Cys-LT) receptors 1 and 2 in the nasal mucosa in perennial allergic and non-allergic rhinosinusitis
Authors: X.Q. Wu, A.C. Myers, C.J. Reynolds, A.C. Goldstone, A. Togias, A.M. Sanico
Journal: Journal of Allergy and Clinical Immunology (2005)
The Harvard Medical Unit at Boston City Hospital: An Autobiography, vol 2, part 1: The Peabody-Minot Tradition, 1915-1950; part 2: The Castle-Finland Era, 1951-1974
Authors: Lester S. King
Journal: JAMA (1984)

In an earlier volume (see<i>JAMA</i>1983;249:283), Finland described the founding, course, and achievements of the Thorndike Memorial Laboratory at the Boston City Hospital. This laboratory, which had its inception in 1923 and ceased to exist in 1973, was part of the Harvard Medical Unit at the hospital. In this unit more than 1,400 physicians had received at least part of their training, some but a single year, others several years. From the total number of trainees Drs Finland and Castle have collected 438 autobiographical sketches that relate personal experiences, reactions, impressions, and achievements. Some persons are represented by obituaries. The contributions, which cover the period 1915 to 1974, reflect the tremendous changes in medical science and medical practice. The work is a treasure of fascinating accounts. The daily life of the interns, the personalities and personal relationships, the attitudes, modes of teaching, medical routines, special events, and economic problems
Chest X-ray changes in air space disease are associated with parameters of mechanical ventilation in ICU patients.
Authors: E W Ely, M M Johnson, C Chiles, J T Rushing, D L Bowton, R I Freimanis, R H Choplin, E F Haponik
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

To assess relationships between parameters of mechanical ventilation (MV) and portable chest X-ray (CXR) measurements of lung length (LL) and severity of air space disease, a prospective, randomized, blinded comparison of 102 adults in a university hospital was performed. Each patient received two portable, supine CXRs on different MV breaths within 5 min of one another. Ventilator parameters were recorded. All 204 CXRs were randomly assorted and read independently by three radiologists. Air space disease was considered more severe with pressure support ventilation (PSV) breaths than with intermittent mandatory ventilation (IMV) breaths (p = 0.0003), and its extent correlated inversely with static compliance (p = 0.0001, r = -0.40). Among patients having CXRs on both IMV and PSV breaths, 15 of 67 (22%) had their overall degree of air space disease read differently by one category (mild, moderate, or severe). Increases in LL between the two CXRs were associated with increasing peak (p = 0.0038) or mean (p = 0.0065) airway pressure, tidal volume (VT) (p = 0.022), and VT per kilogram (p = 0.006). We conclude that lung volume changes during MV, typically not noted nor controlled for during portable chest radiography, may substantially alter the interpretation of air space disease and LL. Physicians monitoring intensive care unit (ICU) patients with daily CXRs should be aware of the variables influencing interpretation of portable CXRs of ICU patients.
Penicillin Sensitivity —Continued
Authors: Alan G. Cazort
Journal: JAMA (1965)

<h3>To the Editor:—</h3> We found much interest in Dr. Frank Perlman's experience (<i>JAMA</i><b>192</b>:64-65 [April 5] 1965) with penicilloyl-polylysine as a test for immediate sensitivity to penicillin, as compared with potassium penicillin G. We have, largely through references of many other physicians, been able to study 29 cases which we would accept as examples of anaphylactic shock from penicillin. With one exception, these patients had dyspnea, angio-edema, urticaria, and marked hypotension. The one exception had only urticaria occurring some 30 minutes after the injection, with spontaneous recovery except for some oral antihistaminic. This patient did show a positive reaction, but a weak one, to a scratch test for penicillin G. Only one of the above failed to show an immediate whealing response and erythema to a scratch test with penicillin G, 10,000 units per cubic centimeter. We are now doubting whether the history given in this case was accurate.
Hospital Administration as a Medical Specialty
Authors: T. Stewart Hamilton
Journal: New England Journal of Medicine (1949)

HOSPITAL administration as a medical specialty seems to be disappearing. The change may be more relative than actual, as able lay administrators become increasingly interested in an expanding profession, but few physicians, it seems, even consider the possibility of hospital administration as a career. What does the specialty offer? Should it be abandoned to trained laymen? In the search for answers to these questions, a brief review of the past history and the present status of hospitals and hospital administration may be of value.One of the first hospitals of which there is record was founded by Justinian in Rome . . .
Sudden Death in Doberman Pinschers
Authors: THOMAS N. JAMES
Journal: Annals of Internal Medicine (1968)

In a postmortem study of 11 Doberman Pinschers that had died suddenly, an identical cardiac lesion was found in 10. This was a nearly complete focal degeneration of the His bundle, which was associated with cartilage and bone formation in the adjacent central fibrous body. The cause of these lesions is considered to be luminal narrowing of the local small coronary arteries, which may be a heritable fault. It is postulated that sudden unexpected death in these dogs may be due to a form of Adams-Stokes attack. Pertinence of these observations to human cardiac disease is discussed.
The History of Medical Education
Authors: Robert P. Hudson
Journal: JAMA (1970)

Eighty years have passed since a global history of medical education was encompassed in a single volume. That book by Theodor Puschmann served long and well, but medical education has not escaped the radical change of medicine in general during the past several decades. A new account was needed, and<i>The History of Medical Education</i>, edited by the late C. D. O'Malley, fills the void so well it may discourage any similar venture for the next eight decades. O'Malley's effort grew out of a 1968 International Symposium sponsored by UCLA. Nineteen contributors give this book a remarkable geographic sweep, including areas ignored by Puschmann such as Southeast Asia, Japan, and Latin America. Particularly welcome to us chauvinists was John Field's excellent coverage (and bibliography) of American medical education from the Civil War down to day before yesterday. Most readers are all too aware of the usual defects in a book
Are human studies possible? Some thoughts on the mutation component and population monitoring.
Authors: C Denniston
Journal: Environmental Health Perspectives (1983)

The concept of the mutation component of a genetic trait is discussed and its relation to heritability investigated. It is found that for qualitative traits held in the population by opposing directional selection and mutation, the mutation component equals the broad sense heritability. The mutational component of a quantitative trait with an intermediate optimum is found generally to be between half and one times the (narrow sense) heritability of the character. Although more work on this matter is required, the finding of a relationship between mutation component and heritability should allow us to make better predictions regarding the likely impact of an increased mutation rate on the human population. Some statistical problems relevant to the detection of an increased mutation rate are also discussed.
Mission hospital medicine.
Authors: A Savage
Journal: BMJ (1979)

The egrets, wearing their immaculate plumage, sit on the eucalyptus trees in the evening sun. The nurses, white uniforms surprisingly unblemished, walk slowly back to the locations, and the white cross on the mountain shines down on the  hospital in the Transkei. In OPD (outpatients' department) all is quiet and our overnight guests wrap their blankets round them and settle down to sleep on the benches. Yes?all true. But there's another side to the coin. For the third time that night you slosh, torchlit, through the mud to the hospital. Some fearful problem has just arrived in maternity; the lights have gone out; you've had no mail for a fortnight; and aspirin is out of stock. Both images are familiar. The truth usually lies somewhere between them, yet there must be something about mission hospital  that is intensely satisfying: nostalgic letters are written from all parts of the world; and a substantial number of those who originally came as students for their ?lectives return for a longer period. Not every hospital suits everyone, of course. Where the medical staff numbers a mere handful or less, and contact between them is necessarily close, personality differences may be volcanic; better move than murder, and usually a transfer can be arranged and the square peg dropped into its square hole. The 40 or so  hospitals in the Transkei were taken over by the State about four years ago. The high cost of medicine meant that for many years they had been financed almost entirely from State funds, and the change was a logical one, but it left some problems and little pockets of nostalgia. Letters of supplication that were once written to faithful congregations in the mother countries are now addressed in more formal language to the Department of Health in Umtata, with the same un predictable response. Grave problems, particularly of supply, do exist, and it is easy to throw up one's hands and shout when no one can find any soap, or a long list of O/S (out of stock) drugs is chalked up on the ward blackboard. It is even easier, alas, to take it out on the wretched unqualified girl in the dis pensary when she fails to find what you want. I count myself a sinner here, and a brief spell helping to sort out the drug store has given me a new respect for those who keep the endless stream of supplies flowing through the wards in Britain. It is large scale housekeeping, made all the more difficult because our hospital supplies are also used for about 30 outclinics. One raid by those red-bereted sisters and the analgesics completely dis appear. Fortunately, we are all generalists here, so the medical
VACCINATION.Read before the New York State Medical Association, Fifth District Branch.
Authors: HENRY H. MORTON
Journal: JAMA (1894)

It would almost seem to be a work of supererogation at the present day, with the accumulated experience of the past hundred years, to speak of the protection which vaccination has afforded the human race against smallpox. There are a few people in the community, however, who object to availing themselves of its advantages; the ignorant and uneducated who are willing to suffer the dangers to themselves of sickness and death from smallpox and the certainty of spreading the disease to an indefinite number of others, in order to avoid the slight inconvenience, for a few days, occasioned by the possibility of a sore arm; and the limited number of persons, with some degree of education who, for the sake of a little cheap notoriety, or because of an inborn mental twist, a sort of internal strabismus, which keeps them from looking fairly and straight upon any subject which is
Risk factors for post-ERCP pancreatitis
Authors: A. Kadayifci
Journal: Endoscopy (2008)

We read with great interest the article by Williams et al. [1]. The authors attempted to identify the principal risk factors for endoscopic retrograde cholangiopancreatography (ERCP) complication in a large-scale, prospective multicenter study. As expected, post-ERCP pancreatitis was more frequent than any other complication. Univariable analysis identified eight factors associated with post-ERCP pancreatitis, including pancreatic duct injections. Our endoscopy unit is one of the high-volume ERCP centers in Turkey, performing approximately 80 procedures a month. Based on our personal experience, we would like to raise two issues related to the Williams data and post-ERCP pancreatitis.
Impact of Diabetes on Long-Term Prognosis in Patients With Unstable Angina and Non–Q-Wave Myocardial Infarction
Authors: Klas Malmberg, Salim Yusuf, Hertzel C. Gerstein, Joanne Brown, Feng Zhao, David Hunt, Leopoldo Piegas, James Calvin, Matyas Keltai, Andrzej Budaj, for the OASIS Registry Investigators
Journal: Circulation (2000)

Although unstable coronary artery disease is the most common reason for admission to a coronary care unit, the long-term prognosis of patients with this diagnosis is unknown. This is particularly true for patients with diabetes mellitus, who are known to have a high morbidity and mortality after an acute myocardial infarction.Prospectively collected data from 6 different countries in the Organization to Assess Strategies for Ischemic Syndromes (OASIS) registry were analyzed to determine the 2-year prognosis of diabetic and nondiabetic patients who were hospitalized with unstable angina or non-Q-wave myocardial infarction. Overall, 1718 of 8013 registry patients (21%) had diabetes. Diabetic patients had a higher rate of coronary bypass surgery than nondiabetic patients (23% versus 20%, P:<0.001) but had similar rates of catheterization and angioplasty. Diabetes independently predicted mortality (relative risk [RR], 1.57; 95% CI, 1.38 to 1.81; P:<0.001), as well as cardiovascular death, new myocardial infarction, stroke, and new congestive heart failure. Moreover, compared with their nondiabetic counterparts, women had a significantly higher risk than men (RR, 1.98; 95% CI, 1.60 to 2.44; and RR, 1.28; 95% CI, 1.06 to 1.56, respectively). Interestingly, diabetic patients without prior cardiovascular disease had the same event rates for all outcomes as nondiabetic patients with previous vascular disease.Hospitalization for unstable angina or non-Q-wave myocardial infarction predicts a high 2-year morbidity and mortality; this is especially evident for patients with diabetes. Diabetic patients with no previous cardiovascular disease have the same long-term morbidity and mortality as nondiabetic patients with established cardiovascular disease after hospitalization for unstable coronary artery disease.
The Oath: A Surgeon Under Fire
Authors: Iain McClure
Journal: BMJ (2004)

Have you ever wondered, after a hard week at work, why you decided to become a doctor? If so, you might want to read this book. It should make any woes you might have pale into insignificance. It might also lead you to reflect on the continuing significance of the Hippocratic oath. In this gripping true story Khassan Baiev, a surgeon from Chechnya, has provided his own interpretation of Hippocrates' ancient touchstone of medical ethics. Part autobiography, part history lesson, part drama, the book is a page turner not because of its literary style (Baiev …
Hyperinsulinemia and Macrosomia
Authors: Robert Schwartz
Journal: New England Journal of Medicine (1990)

Macrosomia is a characteristic feature of diabetic pregnancy. The infants of mothers with diabetes mellitus (especially those with poorly controlled insulin-dependent diabetes or gestational diabetes) have increased body fat and selective organomegaly, including cardiomegaly, but Normal-Sized brains and kidneys.1 In contrast, infants whose large size at birth is due to genetic reasons are proportional.Pedersen proposed more than 35 years ago that macrosomia was due to fetal hyperinsulinism.2 This proposal was based primarily on his study of maternal and infant blood glucose concentrations and was supported by the findings of pancreatic-islet hypertrophy and beta-cell hyperplasia in the infants. Careful analysis . . .
The Exercise Tolerance Test
Authors: Arthur M. Master
Journal: JAMA (1968)

<h3>To the Editor:—</h3> This letter concerns the published reply to the question of "recommendations regarding the equipment and performance desirable in the Master '2-step' exercise tolerance test" (<b>203</b>:161,1968). Only in the first sentence of his long answer does Crawford W. Adams, MD, reply to the question and that only indirectly. He refers the questioner to an article by us, Master and Rosenfeld, (<i>Mod Conc Cardiov Dis</i><b>36</b>:19 [April] 1967). Dr. Adams then proceeds to give gratuitous and dangerous advice which is at variance with our own views. His advice may be harmful to the patient, and if followed, may subject the physician to legal suit for the production of heart attacks. In addition, some of the "precautions" advocated seem cumbersome, impractical, and unnecessary. Dr. Adams states that the test should be performed preferably by two physicians and "precautions include an emergency drug tray, an intravenous infusion set, oxygen,