tbuckley/cabot-search huggingface dataset:
A common mutation in the gene for coagulation factor XIII‐A (VAL34Leu): A risk factor for primary intracerebral hemorrhage is protective against atherothrombotic diseases
Authors: Donato Gemmati, Maria L. Serino, Alessia Ongaro, Silvia Tognazzo, Stefano Moratelli, Riccardo Resca, Mauro Moretti, Gian L. Scapoli
Journal: American Journal of Hematology (2001)

Abstract The role of a common polymorphism in the factor XIII A‐subunit gene (FXIII Val34Leu) has been recently investigated as a protective genetic factor against arterial and venous thrombosis. In addition, the less frequent Leu34 allele has been described as a risk factor for intracerebral hemorrhage. We evaluated the prevalence of this polymorphism by PCR in three case‐control studies of patients diagnosed as having primary intracerebral hemorrhage (PCH, n = 130), coronary heart diseases (CHD, n = 240; myocardial infarction/no myocardial infarction, 120/120), and cerebrovascular diseases (CVD, n = 240; cerebral infarction/transient ischaemic attack, 120/120). The matched control groups consisted of patients admitted to the hospital without history of vascular disease. In addition, 200 healthy subjects were investigated. The frequency of the mutated allele (Leu34) was higher in patients with PCH than in controls (33.8% vs. 23.1%, P = 0.009) and lower in CHD and CVD patients compared to controls (18.1% vs. 25.2%, P = 0.010 and 17.3% vs. 24.2%, P = 0.011, respectively). Moreover, among the patients with CHD, the Leu34 allele was underrepresented in cases with myocardial infarction than without (12.9% vs. 23.3%, P = 0.004) and than in controls (12.9% vs. 25.2%, P &lt; 0.001). Similar findings were obtained in patients with CVD comparing the cases with cerebral infarction versus cases with transient ischaemic attack (12.5% vs. 22.1%, P = 0.008) and versus controls (12.5% vs. 24.2%, P &lt; 0.001). Finally, considering altogether the groups of ischaemic patients (CHD and CVD, n = 480), it was noted a trend towards a higher mean age of the clinical onset in homozygotes for the Leu allele than in the wild types ( P = 0.078). This study indicates that in our population possession of the FXIII Val34Leu mutation predisposes to the occurrence of primary intracerebral hemorrhage and protects against cerebral and myocardial infarction. A wider modulatory role in the progression and onset of atherothrombotic diseases could be ascribed to FXIII Val34Leu. Am. J. Hematol. 67:183–188, 2001. © 2001 Wiley‐Liss, Inc.
Laboratory-Acquired Rocky Mountain Spotted Fever
Authors: Charles N. Oster, Donald S. Burke, Richard H. Kenyon, Michael S. Ascher, Philip Harber, Carl E. Pedersen
Journal: New England Journal of Medicine (1977)

Nine patients with laboratory-acquired Rocky Mountain spotted fever were seen during the period 1971 to 1976. Investigation of each case revealed either definite or probable exposure to an aerosol containing infectious rickettsiae; in no case was there evidence of parenteral exposure either by accidental self-inoculation or by tick bite. These illnesses are believed to represent infection acquired via the respiratory route. This report emphasizes the aerosol hazard of Rickettsia rickettsii in the laboratory and discusses the possibility of respiratory transmission of Rocky Mountain spotted fever in nature. The illness occurred only in personnel who had received either no vaccination or the primary series of the commercial (Lederie) vaccine against this infection. Other personnel who had received the primary series with multiple booster vaccinations demonstrated increased immunity as measured by humoral antibody titers and rickettsial antigen-induced lymphocyte transformation; no cases of clinical disease developed in these multiply-vaccinated personnel.
Impact of Worksite Health Promotion on Health Care Costs and Utilization
Authors: Janet L. Bly
Journal: JAMA (1986)

This study explores the relationship between exposure to a comprehensive worksite health promotion program and health care costs and utilization. The experience of two groups of Johnson & Johnson employees (N = 5192 and N = 3259) exposed to Live for Life, a comprehensive program of health screens, life-style improvement programs, and worksite changes to support healthier life-styles, was compared with that of a control group (N = 2955) over a five-year period. To account for baseline differences, analyses of covariance produced adjusted means for inpatient hospital costs, admissions, hospital days, outpatient costs, and other health costs. Mean annual inpatient cost increases were $43 and $42 for two Live for Life groups vs $76 for the non-Live for Life group. Live for Life groups also had lower rates of increase in hospital days and admissions. No significant differences were found for outpatient or other health care costs.
Laser vs Cryotherapy for CIN and a LEEP of Faith
Authors: Robert K. DeMott
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Regarding the article written by Drs Huggins and Wentz<sup>1</sup>on cervical intraepithelial neoplasia (CIN), I take strong exception to their statement that "most gynecologists will proceed with laser ablation of the cervix.. once a diagnosis of [CIN] is made, if the perimeters of the lesion can be visualized." We certainly hope that this statement is not true. Cryotherapy of ectocervical lesions has been the gold standard and mainstay therapy for many years. The development of laser ablation of these lesions has never been proven to be more effective in eradication of early CIN. The laser therapy contributed only to a monumental increase in the cost of treatment of this disease. Unfortunately, if an expensive carbon dioxide laser has been purchased, its cost must be recovered. If a physician had a choice between laser therapy and cryotherapy, both of which are equally effective, and the physician needed
Maternal age influences risk for HLA-B27 associated ankylosing enthesopathy in transgenic mice.
Authors: S Weinreich, B Hoebe, P Ivanyi
Journal: Annals of the Rheumatic Diseases (1995)

OBJECTIVE--To study further the temporal clustering of ankylosing enthesopathy (AE) noted originally during a study of the influence of mouse major histocompatibility complex (MHC) H-2 and transgenic HLA-B27 on the frequency of AE. METHODS--The relationship between maternal age at littering and frequency of AE was analysed. RESULTS--Mice born to mothers aged eight months or older had a significantly lower disease frequency of AE than mice born to mothers younger than eight months of age. This phenomenon was observed in three independent cohorts evaluated to date (p &lt; 0.01, 0.025, and 0.05). CONCLUSION--Maternal age is a novel, non-genetic risk factor as defined in relation to an MHC associated enthesopathy. Its mode of action and relevance to human disease require further investigation.
A Phase II Study of Celecoxib in Combination with Paclitaxel, Carboplatin, and Radiotherapy for Patients with Inoperable Stage IIIA/B Non–Small Cell Lung Cancer
Authors: Robert Mutter, Bo Lu, David P. Carbone, Ildiko Csiki, Luigi Moretti, David H. Johnson, Jason D. Morrow, Alan B. Sandler, Yu Shyr, Fei Ye, Hak Choy
Journal: Clinical Cancer Research (2009)

Abstract Purpose: Cyclooxygenase (COX)-2 up-regulation plays an important role in the pathogenesis of lung cancer. Selective COX-2 inhibitors have promoted chemosensitivity and radiosensitivity of tumor cells in preclinical trials. Experimental Design: In a single-institution phase II study, we sought to determine the effectiveness of concurrent chemoradiation given with celecoxib and examined biomarkers to predict response to COX-2 inhibition. Results: Seventeen patients with stage IIIA or IIIB non–small cell lung cancer (NSCLC) were enrolled in the study. All received 400 mg celecoxib twice daily continuously while on trial in addition to concurrent chemoradiation therapy with paclitaxel and carboplatin. Celecoxib was continued until disease progression. The overall objective response rate was 42.9%, and the median overall survival time was 203 days. In contrast to nonresponders, those patients with complete and partial responses had a significant decrease in the level of urinary 11α-hydroxy-9,15-dioxo-2,3,4,5-tetranor-prostane-1,20-dioic acid (PGE-M), the major metabolite of prostaglandin E2, after 1 week of celecoxib administration. Patients with very high levels of PGE-M before initiation of therapy also responded poorly to therapy. Serum vascular endothelial growth factor levels did not predict response or survival. Conclusion: The trial was terminated because it did not meet the predetermined goal of 80% overall response rate. In unselected patients, the addition of celecoxib to concurrent chemoradiotherapy with inoperable stage IIIA/B NSCLC does not improve survival. Urinary PGE-M is a promising biomarker for predicting response to COX-2 inhibition in NSCLC.
The Board and Clinical Competence
Authors: CHARLES K. TASHIMA
Journal: Annals of Internal Medicine (1973)

Letters, Comments, and Corrections1 January 1973The Board and Clinical CompetenceCHARLES K. TASHIMA, M.D.CHARLES K. TASHIMA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-1-148 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Echoing the concern expressed by Dr. Ureles (Ann Intern Med 77:476, 1972) that the new procedure of the American Board of Internal Medicine for evaluating the clinical competence of candidates does not adequately emphasize the compassion and empathy we should expect from our resident physicians, I would like to relate briefly our recent experience.During the discussion of our first two candidates, our evaluation committee quickly realized that they wished to judge the residents on more than what had been set forth on the American Board of Internal Medicine forms. The criteria did not seem to reflect...References1. PETERSDORFBECK RJ: The new procedure for evaluating the clinical competence of candidates to be certified by the American Board of Internal Medicine. Ann Intern Med 76:491-496, 1972 LinkGoogle Scholar2. WEED L: Medical Records, Medical Education, and Patient Care. Cleveland, The Press of Case Western Reserve University, 1970, pp. 4-5 Google Scholar3. WEED L: Rules for the auditor, In The Problem-Oriented System, edited by HURST JW, WALKER HK. New York, Medcom Press, Inc., 1972, pp. 105-110 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Saint Francis Hospital Honolulu, Hawaii PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1973Volume 78, Issue 1Page: 148-149 Issue Published: 1 January 1973 PDF downloadLoading ...
A randomized comparison of unipolar versus bipolar recordings as a guide for segmental pulmonary vein isolation
Authors: Hiroshi Tada, Hakan Oral, Mehmet Ozaydin, Aman Chugh, Christoph Scharf, Sohail Hassan, Radmira Greenstein, Frank Pelosi, Bradley P. Knight, S.Adam Strickberger, Fred Morady
Journal: Journal of the American College of Cardiology (2002)
THE CLINICAL AND PATHOLOGIC RELATIONSHIPS OF HYPERPLASTIC AND NONHYPERPLASTIC GOITER
Authors: H. S. PLUMMER
Journal: JAMA (1913)

The study of the clinical and pathologic relationships of the various types of goiter has of necessity been followed with the greatest interest in the surgical clinics. In a short paper it is impossible to review the various contributions to the subject. The following points, however, may be selected from the work done in these clinics: the clinical classification of the cases of goiter into simple or exophthalmic or equivalent terms, and the pathologic classification of the thyroids removed at operation into those with and those without sufficient hyperplastic or hypertrophic changes to characterize the gland; the recognition of toxic-goiter heart in a certain percentage of cases that are not diagnosed exophthalmic goiter and a less generally well-defined idea that the cardiac damage is only one of the manifestations of a general toxicosis; the finding of hyperplastic changes in from 70 to 90 per cent, of the thyroids removed for
Evolution of Sp Transcription Factors
Authors: Kevin J. Kolell, Douglas L. Crawford
Journal: Molecular Biology and Evolution (2002)

The Sp family of transcription factors binds GC-rich DNA sequences. The ubiquitously expressed Sp1 and Sp3 have been well characterized in mammals. Presented here is the characterization of the only Sp protein expressed in the liver or heart tissue of the teleost fish Fundulus heteroclitus. This protein, fSp3, is most similar to and homologous with mammalian Sp3 proteins. The evolution of the Sp transcription family is described, with Sp1 and Sp3 representing the most recent duplication of the Sp family. Sp4 appears to be the most ancestral member. Sp1, Sp3, and Sp4 form a monophyletic group without Sp2. Sp2 is the least similar of the Sp family and is more similar to the non-Sp transcription factors. These results suggest that Sp2 should not be considered a member of the Sp family. Only two domains (zinc fingers and B domain) share similarity outside the Sp family. The zinc fingers are homologous to other GC-binding domains, yet the B domain is homologous to protein-protein interacting domains in the CCAAT-binding/NF-Y transcription factor families. These results suggest that these different domains have different evolutionary histories.
DELAYED CHLOROFORM POISONING AND ALLIED CONDITIONS.A NOTE ON THE CAUSE OF THE ANATOMIC AND CLINICAL CHANGES OBSERVED.
Authors: H. GIDEON WELLS
Journal: JAMA (1906)

During the past two years surgeons have been arousedto the importance and frequency of delayed chloroform poisoning, and the literature of the subject has received a number of important additions.This has been so thoroughly discussed in the recent article by Bevan and Favill1 that it is unnecessary to go into the details of the matter here, beyond mentioning a few of the salient features.The condition rarely results from ether nar- cosis, but follows chloroform narcosis in probably no insignificant proportion, if we include all the non-fatal
Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C
Authors: Naoki Hiramatsu, Norio Hayashi, Kazuhiro Katayama, Kiyoshi Mochizuki, Yuko Kawanishi, Akinori Kasahara, Hideyuki Fusamoto, Takenobu Kamada
Journal: Hepatology (1994)

Apoptosis is a type of cell death that occurs in acute or chronic hepatitis. It has been suggested to be mediated through Fas antigen. To evaluate the role of apoptosis on liver injury of chronic hepatitis C, we studied the expressions of Fas antigen and hepatitis C virus antigen (core antigen) immunohistochemically. Forty liver biopsy samples from patients with type C chronic liver disease were immunostained for Fas antigen and hepatitis C virus antigen. Expression of Fas antigen was found mainly in the cytoplasm of hepatocytes, and these positive cells were found particularly among infiltrating lymphocytes at the advancing edges of "piecemeal necrosis." The histological activity index showed inflammation of both portal and periportal areas to be more severe in the Fas antigen-positive samples than in the Fas antigen-negative ones (p < 0.05 and p < 0.001, respectively). Furthermore, semiquantitative analysis revealed more expression of Fas antigen in the liver tissues with active inflammation than in those without it (p < 0.01). The prevalence of Fas antigen expression in the hepatitis C virus antigen-positive group was higher than that in the hepatitis C virus antigen-negative group (p < 0.05). Our findings suggest that Fas antigen expression (apoptosis) plays an important role in inflammation in the hepatitis C virus-infected liver, particularly in the active inflammation of chronic hepatitis C.
Whole-Body 99mTc-Octreotide Scintigraphy With SPECT/CT to Detect Occult Tumor Inducing Paraneoplastic Osteomalacia
Authors: Napoleão Ramalho Rodrigues, Ana Luisa Calich, Mauricio Etchebehere, Wilson Andre Ichiki, Fabio Payao Pereira, Elaine Maria Ingrid Amstalden, Elba Cristina de Sa Etchebehere
Journal: Clinical Nuclear Medicine (2014)

A 32-year-old woman presented with progressive myalgia, bone pain, fatigue, insufficiency hip fractures, high urine phosphate, and low serum phosphate and vitamin D levels. These findings were suggestive of oncogenic osteomalacia. A whole-body 99mTc-octreotide scintigraphy with SPECT/CT showed uptake on a sclerotic intramedullary lesion in the left medial tibia plateau. MRI depicted a solid lesion. The lesion was surgically removed; the patient became asymptomatic, and follow-up laboratory results normalized. Histopathologic examination revealed a vascular hemangiopericytoma-like tumor, positive for somatostatin receptor (SSR-2). Whole-body 99mTc-octreotide scintigraphy with SPECT/CT may detect occult oncogenic osteomalacia tumors.
Membership in County and National Societies.
Authors: William M. Cummings
Journal: JAMA (1902)

San Diego, Cal., Feb. 28, 1902. <h3>To the Editor:</h3> —InThe Journalof February 22, page 525, is a communication suggesting to the effect that a clause in the by-laws affecting membership in the Association be so drawn as to except from its operation those members who for any reason have not maintained membership in the county society and do not desire to re-enter it. It seems to me that such a clause would be objectionable, distinctly retrograde and impolitic. It is one of the avowed objects, in fact the chief object, of the re-organization to effect a more thorough and perfect organization of the profession generally, and the county society is, by the proposed scheme of reorganization, to be the unit. I submit that it would be, to say the least, impolitic to create a class who might remain members of the Association and yet not be members of
Abstract 3031: Screening for plasma micro RNAs as biomarkers for breast cancer detection
Authors: Catalin Marian, Ionut Bebu, Danesh Kella, Xin Zhou, Md Islam, Habtom Ressom, Peter Shields, Yun-Ling Zheng
Journal: Cancer Research (2010)

Abstract Introduction: MicroRNAs (miRNAs) are small, non-coding RNA molecules that play critical roles in a variety of physiological and pathological processes, including carcinogenesis of breast cancer. The research regarding miRNA discovery and characterization is emerging and there is consensus in the literature that miRNAs are excellent candidate biomarkers for human cancer. Cancer specific miRNAs have been detected in tumors as well as in serum, plasma, and other body fluids. However, no extensive profiling of circulating miRNAs in breast cancer patients has been done to date, although several studies investigated a limited number of miRNA panels. Methods: We investigated the miRNA profile in plasma samples collected before surgery from 10 pathologically confirmed breast cancer patients, one month after surgery from 2 breast cancer patients, and from 10 healthy women controls that were frequency matched to cases on age and race. RNA was extracted from plasma using the mirVana Paris RNA isolation kit (Ambion) and miRNA profiling was done using the TaqMan® Human MicroRNA Array Set v.2.0 (Applied Biosystems), enabling the detection of 667 human mature miRNAs. Plasma miRNA levels were calculated using the well established comparative Ct method (ΔΔCt) relative to the selected controls, and both Wilcoxon rank-sum tests and t tests were used to compare plasma miRNA levels between control subjects and cancer patients. Correlation between miRNAs was assessed separately in cancer and control subjects. Results: Ten miRNAs (1.5% of total) were detected in plasma of all subjects and 12 miRNAs (1.8% of total) were detected in at least 80% of cases and controls, respectively. Of these, 17 miRNAs presented a significant differential expression in plasma between cases and controls (p&amp;lt;0.05). Only one of these (has-miR-191) was previously described as being differentially expressed in breast cancer tissue compared to normal breast tissue. Based on their ability to discriminate between cancer and controls, their fold change, p values, correlation coefficients and post-surgical levels, we selected 6 candidate miRNAs that will be validated in a larger sample set of 50 cases and 50 controls. The p values of these six candidates ranged between &amp;lt;0.0001 and 0.005 and the fold change between cases and controls ranged from 33.85 to 111.80. Conclusion: We identified several circulating miRNAs that are differentially expressed between breast cancer patients and normal controls, and therefore could serve as biomarkers for breast cancer detection if confirmed by future studies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3031.
Push-and-Pull Enteroscopy Using a Single-Balloon Technique for Difficult Colonoscopy
Authors: A. May, l. Nachbar, C. Ell
Journal: Endoscopy (2006)

Several factors predict difficult or incomplete colonoscopy with a standard colonoscope, including female gender, low body mass index, extensive diverticulosis, and prior pelvic surgery.A push-and-pull enteroscopy device and a single-balloon technique was used in 14 patients (six men, eight women; mean age 62 +/- 15 years) after failure of ileocolonoscopy or endoscopic therapy using either a standard or a pediatric colonoscope. The original ileocolonoscopy had been performed to investigate colon polyps (n = 6), an obscure inflammatory process in the ileocecal region (n = 6), or iron deficiency anemia with a positive fecal occult stool test (n = 2).Ileocolonoscopy was successfully performed using this push-and-pull technique in all 14 patients without technical problems or complications. All the endoscopic therapeutic interventions that were required were also performed without complications, with the exception of one instance of bleeding. Multiple polyps were found in six patients; a colon cancer was found in one patient; appendicitis combined with a carcinoid tumour of the appendix was diagnosed in one patient; ileocolitis was observed in two patients; one patient with Crohn's disease had stenoses in the region of an anastomosis; and in three patients no relevant pathological finding was seen.It was possible to perform ileocolonoscopy with therapeutic interventions using this new thin push-and-pull enteroscopy device with a single-balloon technique in patients who had previously undergone incomplete colonoscopy using a standard colonoscope.
Identification of low-frequency variants associated with gout and serum uric acid levels
Authors: Patrick Sulem, Daniel F Gudbjartsson, G Bragi Walters, Hafdis T Helgadottir, Agnar Helgason, Sigurjon A Gudjonsson, Carlo Zanon, Soren Besenbacher, Gyda Bjornsdottir, Olafur T Magnusson, Gisli Magnusson, Eirikur Hjartarson, Jona Saemundsdottir, Arnaldur Gylfason, Adalbjorg Jonasdottir, Hilma Holm, Ari Karason, Thorunn Rafnar, Hreinn Stefansson, Ole A Andreassen, Jesper H Pedersen, Allan I Pack, Marieke C H de Visser, Lambertus A Kiemeney, Arni J Geirsson, Gudmundur I Eyjolfsson, Isleifur Olafsson, Augustine Kong, Gisli Masson, Helgi Jonsson, Unnur Thorsteinsdottir, Ingileif Jonsdottir, Kari Stefansson
Journal: Nature Genetics (2011)
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
Authors: Yuko Matsumoto, Hiroyuki Marusawa, Kazuo Kinoshita, Yoko Endo, Tadayuki Kou, Toshiyuki Morisawa, Takeshi Azuma, Il-Mi Okazaki, Tasuku Honjo, Tsutomu Chiba
Journal: Nature Medicine (2007)
Identification of CCR9− murine plasmacytoid DC precursors with plasticity to differentiate into conventional DCs
Authors: Andreas Schlitzer, Jakob Loschko, Katrin Mair, Roger Vogelmann, Lynette Henkel, Henrik Einwächter, Matthias Schiemann, Jan-Hendrik Niess, Wolfgang Reindl, Anne Krug
Journal: Blood (2011)