tbuckley/cabot-search huggingface dataset:
Smokers to be excluded from Jakarta's free healthcare schemes
Authors: B. Bland
Journal: BMJ (2010)

Health officials in Jakarta are planning to exclude smokers and their families from the city’s free healthcare schemes for low income households.

Fauzi Bowo, the governor of the Indonesian capital city, said that it was unfair for the city administration to continue subsidising those who did not properly look after their health by continuing to smoke.

“A survey showed low income families spent 22% of their income on cigarettes. These people enjoy free health care while still smoking, which worsens their health. This is not fair,” he was reported as saying by the Jakarta Post . …
Structural diversity and African origin of the 17q21.31 inversion polymorphism
Authors: Karyn Meltz Steinberg, Francesca Antonacci, Peter H Sudmant, Jeffrey M Kidd, Catarina D Campbell, Laura Vives, Maika Malig, Laura Scheinfeldt, William Beggs, Muntaser Ibrahim, Godfrey Lema, Thomas B Nyambo, Sabah A Omar, Jean-Marie Bodo, Alain Froment, Michael P Donnelly, Kenneth K Kidd, Sarah A Tishkoff, Evan E Eichler
Journal: Nature Genetics (2012)
Presence of high contents of thymus and activation-regulated chemokine in platelets and elevated plasma levels of thymus and activation-regulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis
Authors: Takao Fujisawa, Ryuichi Fujisawa, Yoshiko Kato, Takashi Nakayama, Atsushi Morita, Hajime Katsumata, Hisashi Nishimori, Kousei Iguchi, Hitoshi Kamiya, Patrick W. Gray, David Chantry, Ryuji Suzuki, Osamu Yoshie
Journal: Journal of Allergy and Clinical Immunology (2002)
US court says federal money can be used for embryonic stem cell research
Authors: J. H. Tanne
Journal: BMJ (2011)

On 29 April the US Court of Appeals for the District of Columbia Circuit ended the injunction prohibiting government funding of research using human embryonic stem cells. The court said that the National Institutes of Health can use federal money to support research using these cells.

Although the ruling is a success for President Barack Obama’s administration and the judges’ opinions supported President Obama’s position, the battle will continue in a lower court.

The injunction was issued last August by Judge Royce Lamberth of the US District Court for the District of Columbia, a lower court. The case was brought by two scientists who work with adult stem …
A multicenter, randomized, placebo-controlled trial of a new form of intravenous recombinant tissue-type plasminogen activator (activase) in acute myocardial infarction
Authors: Eric J. Topol, Douglas C. Morris, Richard W. Smalling, Richard R. Schumacher, Charles R. Taylor, Akira Nishikawa, Henry A. Liberman, Désiré Collen, Margaret E. Tufte, Elliott B. Grossbard, William W. O’Neill
Journal: Journal of the American College of Cardiology (1987)
Aetiology and Management of Lesions of the Feet in Diabetes
Authors: W. Oakley, R. C. F. Catterall, M. M. Martin
Journal: BMJ (1956)

It is generally held that there is an association between diabetes and arterial disease.Joslin et al. (1940) state that " arteriosclerosis is excessive and has become the major cause of death among diabetics generally," and this view has many supporters.Opinion, however, differs on the nature of the arterial lesion, which is regarded by some-for example, Warren and Le Compte (1952), Barach and Lowy (1952), and Katz and Stamler (1953)-as atherosclerosis, and by others-for example, Lundbaek (1954)-as a specific form of angiopathy associated with long-standing diabetes.Histologically it would appear to be impossible to diffe.entiate between non-diabetic and diabetic arterial disease, and, although Lundbaek and Posborg Petersen (1953) have found statistically significant differences in the calcium, cephalin, and lecithin content of the coronary arteries in non-diabetic and diabetic subjects, these differences are admitted by them to be small.Lundbaek bases his belief on the existence of specific diabetic angiopathy largely on statistical grounds, sex incidence, and the presence of such associated lesions as retinopathy and the renal lesions described by Kimmelstiel and Wilson (1936).
The 21st Century Brain: Explaining, Mending and Manipulating the Mind
Authors: Iain McClure
Journal: BMJ (2005)

Perhaps “zeitgeist” is the word for it; “the spirit of the age” is how my dictionary translates it; and Steven Rose dissects and unfolds it, as possibly no other writer in his field can, in this awesome account of the most complex structure in the known universe. What is it ? It is that sense that many of us have, at whatever level of understanding, that our cumulated edifice of scientific knowledge will soon empower humanity with the simultaneously thrilling, yet terrifying, ability—to fully explain, mend, and manipulate the mind.
Is There Functional Collateral Flow During Vascular Occlusion in Angiographically Normal Coronary Arteries?
Authors: Kerstin Wustmann, Stephan Zbinden, Stephan Windecker, Bernhard Meier, Christian Seiler
Journal: Circulation (2003)

Background— Thus far, it is unknown whether there is functional collateral flow through preexisting anastomoses in patients with angiographically normal coronary arteries. Such preformed coronary collateral vessels could form the basis for subsequently developing protective natural bypasses in the presence of coronary artery disease. Methods and Results— Among 100 patients, the collateral flow index (CFI) was measured in coronary arteries without stenotic lesions. The CFI was determined by simultaneous measurement of mean aortic pressure, central venous pressure, and coronary wedge pressure via a sensor-tipped guidewire at the end of a 1-minute balloon occlusion. Patients were divided in 2 groups according to complete angiographic absence (51 patients) or partial presence (49 patients) of stenotic lesions in coronary arteries other than that undergoing collateral measurement. CFI in all patients (61±10 years; men/women, 69/31) amounted to 0.18±0.08 (range, 0.04 to 0.36). It showed a normal Gaussian frequency distribution; 22 individuals had a CFI ≥0.25, a value that was empirically found to represent well-developed collaterals protective against myocardial ischemia during coronary occlusion. Accordingly, 17 patients did not reveal signs of myocardial ischemia during coronary balloon occlusion, as assessed from an intracoronary ECG, and 26 patients did not experience angina pectoris during occlusion. Conclusion— In humans with angiographically normal coronary arteries, there are functional collateral vessels to the extent that one fifth to one quarter of them do not show signs of myocardial ischemia during brief vascular occlusions.
Relation between Plasma and Red-Cell Electrolyte Concentrations and Digoxin Levels in Children
Authors: Michael W. Loes, Sharanjeet Singh, James E. Lock, Bernard L. Mirkin
Journal: New England Journal of Medicine (1978)

We determined alterations in plasma and red-cell electrolyte concentrations associated with digoxin administration in 11 children in heart failure, 24 nontoxic patients receiving maintenance digoxin and 11 children in whom digoxin toxicity developed. Twenty normal children served as controls. Digoxin therapy was associated with a mean (± S.E.M.) increase in red-cell sodium from a pretreatment level of 6.2±0.7 meq per liter to 11.9±1.2 meq per liter and a decrease in red-cell potassium from 105.4±1.4 to 99.5±1.9 meq per liter (P<0.001). The red-cell sodium levels of toxic patients exceeded those of nontoxic patients whereas the potassium concentrations were lower (P<0.001). Toxic patients manifested significantly higher ratios of red-cell sodium to red-cell potassium (0.213±0.003) than nontoxic patients (0.085±0.008; P<0.001). Changes in red-cell electrolytes are sensitive indicators of digoxin effects. (N Engl J Med 299:501–504, 1978)
Sensitization to cockroach as a marker of asthma severity among probable asthmatic (PA) adolescents identified by the international study of asthma and allergies in childhood (ISAAC) protocol
Authors: Dirceu Solé, Inês C Camelo Nunes, Gustavo F Wandalsen, Karyn Chacon, Charles Naspitz
Journal: Journal of Allergy and Clinical Immunology (2002)
Suicide and Suggestibility—The Role of the Press
Authors: JEROME A. MOTTO
Journal: American Journal of Psychiatry (1967)

The assertion that newspaper reporting of suicidal behavior precipitates suicide among suggestible readers was examined. The rates of suicide during periods of complete cessation of newspaper publishing in seven major cities were compared with the mean rates for the same calendar periods of the prior five years in each city. The sign test and signed-rank test revealed no significant change during the experimental periods. In one area (the island of Oahu) a significant change was noted in the direction contrary to the hypothesis tested. The author agrees with others who have considered this question that whatever deleterious effect newspapers may exert on their readers stems more from the implied and expressed attitudes and value system than from news content.
Erosive Plaque on Scrotum
Authors: Jun Li, Heyi Zheng
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiovascular responses to lower body negative pressure in normal subjects and in patients with diabetes mellitus
Authors: T. BENNETT, D. J. HOSKING, J. R. HAMPTON
Journal: Cardiovascular Research (1979)

The cardiovascular responses of non-diabetic and diabetic subjects to lower body negative pressure at 1.3, 2.7, and 5.3 kPa (10, 20, and 40 mmHg) were measured. The diabetics fell into two groups — those showing little change in systolic blood pressure with lower body negative pressure at 5.3 kPa (40 mmHg) and those showing falls greater than 2.7 kPa (20 mmHg). The patterns of response in the former group of diabetics and in the non-diabetics were similar. The diabetics who showed a fall in systolic blood pressure with lower body negative pressure nonetheless responded with a forearm vasoconstriction indicating that the vasomotor dysfunction was localised to some other vascular bed. In one subject forearm vasodilatation occurred with lower body negative pressure at 5.3 kPa (40 mmHg) although his response to milder levels of lower body negative pressure appeared normal. It is suggested that the integrity of vasomotor reflexes is most reliably tested by exposure to stepped increases in lower body negative pressure.
HIP1–ALK, a Novel Fusion Protein Identified in Lung Adenocarcinoma
Authors: Mineui Hong, Ryong Nam Kim, Ji-Young Song, So-Jung Choi, Ensel Oh, Maruja E. Lira, Mao Mao, Kengo Takeuchi, Joungho Han, Jhingook Kim, Yoon-La Choi
Journal: Journal of Thoracic Oncology (2014)
Inducible nitric oxide synthase mediates the change from retinal to vitreal neovascularization in ischemic retinopathy
Authors: Florian Sennlaub, Yves Courtois, Olivier Goureau
Journal: Journal of Clinical Investigation (2001)

Intravitreal neovascular diseases are a major cause of blindness worldwide. It remains unclear why neovessels in many retinal diseases spread into the physiologically nonvascularized vitreous rather than into the ischemic retinal areas, where the angiogenic factors are released. Here we show that inducible nitric oxide synthase (iNOS) is expressed in the ischemic retina. Using iNOS knockout mice and the iNOS inhibitor 1400W, we demonstrate that iNOS expression inhibits angiogenesis locally in the avascular retina, mediated at least in part by a downregulation of VEGF receptor 2 (VEGFR2) in cells adjacent to iNOS-expressing cells. At the same time, pathological intravitreal neovascularization is considerably stronger in iNOS-expressing animals. These findings demonstrate that iNOS plays a crucial role in retinal neovascular disease and show that it offers an ideal target for the control of vitreal neovascularization through improvement of the vascularization of the hypoxic retina.
New Modalities for Treating Chronic Pancreatitis
Authors: H. Grimm, W.-H. Meyer, V. Ch. Nam, N. Soehendra
Journal: Endoscopy (1989)

Over the last few years, a new method, neither medical nor surgical, has been developed for treating often difficult-to-treat chronic pancreatitis. In the case of obstructive pancreatitis, endoscopy permits both drainage and calculus extraction. Even encrusted concrements and calcifications can be removed from the pancreatic duct with the aid of extracorporeal shockwave lithotripsy. The first aim is to relieve pain by restoring a free flow of secretion. Perhaps the use of endoscopic treatment in the early stages will break the vicious circle of chronic inflammation and ultimate gland destruction.
A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency
Authors: Bénédicte Neven, Emilie Mamessier, Julie Bruneau, Sophie Kaltenbach, Daniel Kotlarz, Felipe Suarez, Julien Masliah-Planchon, Katy Billot, Danielle Canioni, Pierre Frange, Isabelle Radford-Weiss, Vahid Asnafi, Dhaarini Murugan, Christine Bole, Patrick Nitschke, Olivier Goulet, Jean-Laurent Casanova, Stéphane Blanche, Capucine Picard, Olivier Hermine, Frederic Rieux-Laucat, Nicole Brousse, Frederic Davi, Véronique Baud, Christoph Klein, Bertrand Nadel, Frank Ruemmele, Alain Fischer
Journal: Blood (2013)
CBFA2T3-GLIS2 fusion transcript is a novel common feature in pediatric, cytogenetically normal AML, not restricted to FAB M7 subtype
Authors: Riccardo Masetti, Martina Pigazzi, Marco Togni, Annalisa Astolfi, Valentina Indio, Elena Manara, Rita Casadio, Andrea Pession, Giuseppe Basso, Franco Locatelli
Journal: Blood (2013)
Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity
Authors: Jürgen K. Naggert, Lloyd D. Fricker, Oleg Varlamov, Patsy M. Nishina, Yves Rouille, Donald F. Steiner, Raymond J. Carroll, Beverly J. Paigen, Edward H. Leiter
Journal: Nature Genetics (1995)
The Measure of the Man
Authors: Charles A. Wittnam
Journal: Annals of Internal Medicine (2008)

On Being a Doctor16 September 2008The Measure of the ManCharles A. Wittnam, MDCharles A. Wittnam, MDFrom Billings Clinic West, Billings, MT 59102.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-6-200809160-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In the Yellowstone River Valley of Montana, a handshake is still important. Here, handshakes are used to settle the sale of land, timber, and cattle. A handshake is always offered in greeting and in farewell. Montanans believe that a handshake provides important information about a person's character, and therefore it is never taken lightly.Toyvo and his wife were new to my practice. They were an elderly couple who were native Montanans. After introducing myself, I offered my hand to Toyvo and was surprised when I was greeted with a powerful grip that seemed out of proportion to the short, ... Author, Article, and Disclosure InformationAffiliations: From Billings Clinic West, Billings, MT 59102.Corresponding Author: Charles A. Wittnam, MD, Billings Clinic West, 2675 Central Avenue, Billings, MT 59102; e-mail, [email protected]org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 September 2008Volume 149, Issue 6Page: 431-432KeywordsElderlyForecastingHand strengthLaboratory testsLibrariesLungsMusclesRiversSurgeryThorax ePublished: 16 September 2008 Issue Published: 16 September 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Management of Cerebral Metastasis
Authors: Lewis J. Brown
Journal: JAMA (1976)

<h3>To the Editor.—</h3> I would like to point out an inconsistency in Dr Lokich's article, "The Management of Cerebral Metastasis" (234:748, 1975), and provide some additional input of my own. Dr Lokich writes that "surgery is employed almost exclusively for solitary lesions in accessible areas," and then proceeds, curiously enough, to describe one of two instances (case 2) in which radiotherapy had been used. We are told that the patient's symptoms were controlled, and that she eventually became asymptomatic, but we are not apprised as to the status of her papilledema. Indeed, even though the three-month followup brain scan seems to show less uptake than the initial study, it is still patently abnormal. I would like to suggest that there is considerable danger in assuming such a lesion to be metastatic, especially from a presumed primary that infrequently disseminates to the cerebrum, and that short of a histological diagnosis, the
Pulmonary thromboembolism presenting as abdominal pain.
Authors: A F Henderson, F Moran, S W Banham
Journal: BMJ (1984)

Pulmonary thromboembolism has protean manifestations.In 1957 Israel and Goldstein described six patients who presented with abdominal symptoms.'Despite this, abdominal pain is not commonly listed as a presenting feature of the condition-for example, it is not mentioned in recent major textbooks of general2 or respiratory3 medicine.We report two patients in whom abdominal pain was the sole presenting feature of pulmonary thromboembolism. Case 1A 55 year old man with a history of rheumatoid arthritis, ischaemic heart disease, and peripheral vascular disease was admitted after the acute onset of severe breathlessness.On admission he was dyspnoeic and distressed with widespread inspiratory crackles in his chest.Radiography confirmed the clinical impression of pulmonary oedema and he responded rapidly to intravenous diuretics.A few hours after admission he became acutelv breathless again and clinical examination once more disclosed the signs of pulmonary oedema.This deterioration coincided with his cardiac rhythm changing from sinus on admission to atrial fibrillation with a ventricular rate of 156 min.His symptoms once more responded to intravenous diuretics and his heart rate was controlled with digoxin.The electrocardio- gram showed atrial fibrillation and incomplete left bundle branch block.His creatinine kinase activity was considerably increased on admission (4800 u/1), falling to normal over the next few days.Activities of other cardiac enzymes remained normal over this period.On the fourth day after admission he complained of pain in the left hypochondrium.Nothing was found on examination and he was given analgesics.A diagnosis of mesenteric ischaemia was considered in view of the history of severe widespread vascular disease and atrial fibrillation, but there was no confirmatory evidence such as rectal bleeding.The next day the pain had become more severe and was worsened by respiration.He coughed up a small amount of fresh blood.On examination a loud pleural rub was heard at the left base laterally.There was no change in the chest radiograph or electrocardiogram.A clinical diagnosis of pulmonary thromboembolism was made and he was anticoagulated with heparin initially and later warfarin.Lactate dehydrogenase activity rose transiently to 1180 u/l after this episode.A ventilation-perfusion lung scan showed a matched ventilation-perfusion abnormality at the right apex and an unmatched perfusion defect at the left base suggestive of the condition.The diagnosis was proved conclusively by a pulmonary angiogram, which showed clear evidence of pulmonary thromboembolism in the left lower lobe.His symptoms subsided over the next few days and he was discharged home taking oral anticoagulants. Case 2A 63 year old engineer presented with general malaise, herpes labialis, and a persistent productive cough.The white cell count was 176x 10 1, the film showed mature lymphocytes, and bone marrow examination con-
Safety of Pediatric HIV Elimination: The Growing Population of HIV- and Antiretroviral-Exposed but Uninfected Infants
Authors: Lynne M. Mofenson, D. Heather Watts
Journal: PLoS Medicine (2014)

Lynne Mofenson and Heather Watts discuss the context and implications of the study by J. Sibuide and colleagues, which provides a detailed analysis of birth defects in infants with in utero antiretroviral drug exposure in the French Perinatal Cohort. Please see later in the article for the Editors' Summary
Rapamycin Selectively Inhibits Angiotensin II–Induced Increase in Protein Synthesis in Cardiac Myocytes In Vitro
Authors: Junichi Sadoshima, Seigo Izumo
Journal: Circulation Research (1995)

Abstract It has been suggested that phosphorylation of a 40S ribosomal protein, S6, regulates protein synthesis. Two distinct families of S6 kinase have been identified, the rsk -encoded 85- to 92-kD S6 kinase (RSK) and the 70- or 85-kD S6 kinase (p70 S6K ). We have previously shown that hypertrophic stimuli, such as angiotensin II (Ang II), rapidly activate RSK in cardiac myocytes. However, RSK and p70 S6K are regulated by distinct mechanisms, and p70 S6K , but not RSK, is the physiological S6 kinase in vivo in other cell types. Using cultured neonatal rat ventricular myocytes, we examined whether Ang II activates p70 S6K and investigated the effect of rapamycin, a potent yet indirect inhibitor of p70 S6K , on the Ang II–induced hypertrophic response. Immunoblot analyses indicate that cardiac myocytes express the 70- and 85-kD forms of p70 S6K . Ang II caused a rapid and sustained activation of p70 S6K through the type I Ang II receptor. Rapamycin inhibited Ang II–induced activation of p70 S6K in a dose-dependent manner, with an IC 50 of 0.14 ng/mL (0.15 nmol/L). Rapamycin did not inhibit Ang II–induced activation of tyrosine kinase, mitogen-activated protein kinase, RSK, and protein kinase C. The effect of rapamycin is unlikely to be mediated by its effect on p34 cdc2 and p33 cdk2 because Ang II did not activate these cell cycle–dependent kinases in cardiac myocytes. In contrast, a dose-dependent inhibition of p70 S6K by rapamycin is very closely correlated with its inhibition of the Ang II–induced increase in protein synthesis. Interestingly, rapamycin did not affect the Ang II–induced activation of specific gene expression, including the immediate-early gene c- fos and fetal type genes, such as atrial natriuretic factor and skeletal α-actin. Moreover, rapamycin did not suppress Ang II–induced phenotypic changes at the protein level, such as increased atrial natriuretic factor secretion, expression of β-myosin heavy chain, and organization of actin into sarcomeric units. These results indicate that p70 S6K is activated by Ang II and that a rapamycin-sensitive signaling mechanism, most likely p70 S6K , plays an essential role in the Ang II–induced increase in overall protein synthesis but not in Ang II–induced specific phenotypic changes in cardiac myocytes.