tbuckley/cabot-search huggingface dataset:
Fish Oils in Rheumatoid Arthritis
Authors: GURKIRPAL SINGH
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 June 1988Fish Oils in Rheumatoid ArthritisGURKIRPAL SINGH, M.B.B.S., M.D., RANJIT KUMAR CHANDRA, M.D.GURKIRPAL SINGH, M.B.B.S., M.D., RANJIT KUMAR CHANDRA, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-6-904_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Kremer and associates (1) could have obtained more convincing results with some alterations in their study design. The more sensitive visual analogue scale should have been used to measure pain in preference to the five-point scale. Moreover, there are several advantages in measuring pain relief directly. When pain is measured on two occasions and the second reading is subtracted from the first, the difference is always proportional to the first reading or the initial severity of pain. Also, when pain scores are subtracted, it is assumed that differences in different parts of the scale are equal; that...References1. KREMER J, JUBIZ W, and MICHALEK A. Fish-oil fatty acid supplementationin active rheumatoid arthritis: a double-blinded, controlled, crossover study. Ann Intern Med. 1987;106:497-503. LinkGoogle Scholar2. HUSKISSON E. Clinical trials and therapeutic evaluation. In: SCOTT JT, ed. Copeman's Textbook of Rheumatic Diseases. London: Churchill Livingstone Inc.; 1986:1581-96. Google Scholar3. SCOTT P and HUSKISSON E. Measurement of functional capacity with visualanalogue scales. Rheumatology and Rehabilitation. 1977;16:257-9. CrossrefMedlineGoogle Scholar4. PANUSH R. Nutritional therapy for rheumatic diseases. Ann Intern Med. 1987;106:619-21. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GURKIRPAL SINGH, M.B.B.S., M.D.; RANJIT KUMAR CHANDRA, M.D.Affiliations: Memorial University of Newfoundland and Janeway Child Health Centre St. John's, Newfoundland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntake of ω-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: A systematic review and meta-analysisMarine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials 1 June 1988Volume 108, Issue 6 Page: 904-905 Keywords Oils Rheumatoid arthritis ePublished: 1 December 2008 Issue Published: 1 June 1988 PDF downloadLoading ...
Abstract A46: HSP-90 inhibition in pediatric sarcomas
Authors: Fernanda I. Arnaldez, Toby Terwilliger, Choh Yeung, Len Neckers, Lee Helman
Journal: Cancer Research (2014)

Abstract Hsp90 is a molecular chaperone that regulates post-translational folding, stability, and function of many client proteins, which play critical roles in key signal transduction pathways implicated in cell growth, differentiation, and survival. Several relevant oncogenic proteins are described as clients, such as insulin growth factor receptor 1, AKT/PKB, and src-family kinases. Signaling through these molecules is critical in the biology of rhabdomyosarcoma and Ewing's sarcoma, which are two of the most common pediatric sarcomas. Novel therapies for these tumors are clearly needed since patients with relapsed and metastatic disease continue to have poor outcomes and multimodality therapy, even when successful, is often accompanied by long-term morbidity. Ganetespib (Synta Pharmaceuticals) is a small molecule Hsp90 inhibitor that binds to the ATP pocket in the N-terminus of Hsp90, leading to down-regulation of Hsp90 client protein levels. We sought to evaluate the preclinical activity of ganetespib in a panel of Ewing's Sarcoma and rhabdomyosarcoma cell lines. We evaluated in vitro activity of ganetespib in Ewing Sarcoma cell lines (TC71, TC32, EW8, RDES) and in rhabdomyosarcoma (RMS) cell lines (RD, RH30) using kinetic proliferation assays and MTS. In all cases, marked inhibition of cell growth was achieved in a dose-dependent manner with drug IC50s in the low nanomolar range (3-6 nM). We found that ganetespib exposure is associated with both induction of apoptosis and alterations in cell cycle progression. In addition to upregulation of Hsp70, which is considered a biomarker of Hsp90 inhibition, ganetespib treatment was associated with loss of expression of IGF1R-beta as well as downregulation of key signaling pathways including mammalian target of rapamycin (mTOR), pAKT, and Src-family kinases, particularly YES1, a kinase we previously identified as critical in rhabdomyosarcoma biology. Moreover, we observed a cooperative effect between Hsp90 inhibition and IGF1R blockade with R1507, a monoclonal antibody targeting this receptor (Hoffman-La Roche). Furthermore, synergy was seen when ganetespib was combined with the SFK inhibitor dasatinib. While in-vivo validation of these results is ongoing, we conclude that Hsp90 inhibition with ganetespib is an attractive strategy to explore for the therapy of pediatric sarcomas, possibly in combination with other targeted therapies. Citation Format: Fernanda I. Arnaldez, Toby Terwilliger, Choh Yeung, Len Neckers, Lee Helman. HSP-90 inhibition in pediatric sarcomas. [abstract]. In: Proceedings of the AACR Special Conference on Pediatric Cancer at the Crossroads: Translating Discovery into Improved Outcomes; Nov 3-6, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;74(20 Suppl):Abstract nr A46.
Abstract 5410: Tim-3 expression and function in natural killer cells from metastatic melanoma patients
Authors: Ines P. da Silva, Sonia Jimenez-Baranda, Anne Gallois, Vijay K. Kuchroo, Iman Osman, Nina Bhardwaj
Journal: Cancer Research (2012)

Abstract BACKGROUND: Tim-3 (T-cell immunoglobulin domain and mucin domain 3) is a type-I glycoprotein receptor with pivotal roles in immune regulation and tolerance induction. Tim-3 has opposing roles in innate and adaptive immunity. It synergizes with TLR signaling in DCs inducing the production of inflammatory cytokines, while it acts as a negative regulator of Th1/Tc1 cell function by triggering T cell apoptosis upon interaction with its ligand, galectin-9. Tim-3 is also responsible for the functional exhaustion of T cells observed in some chronic infectious diseases and tumors, such as metastatic melanoma (MM). Natural Killer (NK) cells, innate immune cells which eliminate tumors and infected cells through cytotoxicity and IFNγ production, constitutively express Tim-3. Moreover, it has been described that some tumor cells (including melanoma cells) express and secrete galectin-9. However, little is known about the role of Tim-3 on NK cells, particularly in the presence of galectin-9, in healthy or melanoma patients. METHODS: Purified NK cells from PBMCs of 20 melanoma donors (MD) and 40 healthy donors (HD) were characterized according to the expression of Tim-3 by flow cytometry. Lamp-1 expression on NK cell surface was used to measure NK cell cytotoxicity against the following target cells: i) K562 cells which don't express Galectin-9 and ii) Gmel galectin-9+ and Gmel galectin-9- sorted melanoma cells. IFNγ production was assessed by intracellular staining after 4 hours culture in presence of IL-12. RESULTS: MD NK cells express higher levels of Tim-3 compared to HD NK cells (p&amp;lt;0.05). Moreover, MD NK cells have a defect in cytotoxicity, proliferation and IFNγ production, but it still remains unclear if Tim-3 is involved in this exhausted phenotype. So far, we found that Tim-3 expression by itself (without engagement of specific ligands) does not negatively affect NK cell cytotoxicity. However, the expression of Galectin-9 by the target cells induces a decrease in NK cell cytotoxicity (Gmel Gal-9+ vs Gmel Gal-9-). CONCLUSION: These data suggest that when engaged with Galectin-9, Tim-3 expression down-modulates NK cell cytotoxicity. Therefore, galectin-9 expression may be a possible mechanism for tumors to evade immune surveillance. Given that an increasing body of data supports an important role for Tim-3/Galectin-9 interaction in immune regulation in infectious diseases and cancer, deciphering the function of Tim-3 in different cell types will be critical for potentially targeting it therapeutically. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5410. doi:1538-7445.AM2012-5410
Interaction of the N-Terminal Domain of the AMPA Receptor GluR4 Subunit with the Neuronal Pentraxin NP1 Mediates GluR4 Synaptic Recruitment
Authors: Gek-Ming Sia, Jean-Claude Béïque, Gavin Rumbaugh, Richard Cho, Paul F. Worley, Richard L. Huganir
Journal: Neuron (2007)
Lung Uptake of Technetium-99m Phosphate Compounds after Liver Transplantation
Authors: IRENE P. RAISIS, CHAN H. PARK, SHUIN L. YANG, WILLIS MADDERY
Journal: Clinical Nuclear Medicine (1988)

Pulmonary calcification can be detected easily using Tc-99m phosphate compounds. Lung uptake of Tc-99m bone imaging agents was observed in two patients after liver transplantation. Transient hypercalcemia due to calcium infusion during hepatic transplantation may be responsible for the pulmonary calcification.
Aortic Obstruction Associated With Methysergide Maleate Therapy for Headaches
Authors: James E. Conley
Journal: JAMA (1966)

Methysergide meleate and members of the ergot family have been associated with fibrous changes and obstruction in larger arteries. Severe aortic- and iliac-artery obstruction occurred in a patient maintained on prolonged and uncontrolled methysergide therapy for headaches. Prompt and complete reversibility of the obstructive changes was shown by aortograms and vascular studies done during the period of obstruction and two months after discontinuation of the therapy. Biopsy done at laparotomy confirmed the retroperitoneal fibrosis.
Book Review Laparoscopic Biliary Surgery By Alfred Cuschieri and George Berci, with Margaret Paz-Partlow, Jonathan Sackier, and L.K. Nathanson. 101 pp., illustrated. Boston, Blackwell Scientific, 1990. $95. (Distributed in the U.S. by Mosby—Year Book, Chicago.)
Authors: Andrew L. Warshaw
Journal: New England Journal of Medicine (1991)
ADF/n-cofilin–dependent actin turnover determines platelet formation and sizing
Authors: Markus Bender, Anita Eckly, John H. Hartwig, Margitta Elvers, Irina Pleines, Shuchi Gupta, Georg Krohne, Elisabeth Jeanclos, Antje Gohla, Christine Gurniak, Christian Gachet, Walter Witke, Bernhard Nieswandt
Journal: Blood (2010)
Abstract 3314: Co-regulation of srGAP1 by Wnt and androgen receptor signaling in castration resistant prostate cancer
Authors: Noriko N. Yokoyama, Toshinori Sakai, Zheng Sun, Shujuan Shao, Jiaoti Huang, Bang H. Hoang, Xiaolin Zi
Journal: Cancer Research (2014)

Abstract Androgen receptor (AR) and Wnt signaling both play a critical role during prostate cancer progression to castration-resistance prostate cancer (CRPC). Over expression of AR can activate transcriptional activities of Wnt signaling pathway and promote CRPC. Recent data in our laboratory showed a potential co-regulation of srGAP1 (Slit-Robo-GTPase activating protein1) and active Wnt and AR signaling in CRPC. srGAP1 is a downstream component of Slit-Robo signaling. Our data showed that srGAP1 is overexpressed in CRPC cell lines (androgen-insensitive prostate cancer) while absent in both androgen-sensitive cells and in normal prostate epithelial cells. We also detected increased srGAP1 expression in human CRPC tissues compared with normal epithelial prostate and androgen sensitive prostate cancer tissues by immunohistochemistry analysis. When androgen-sensitive LNCaP cells were grown under androgen deprived condition, we observed induced expression of srGAP1. Interestingly, srGAP1 expression was also increased when LNCaP cells were grown under Wnt stimulated conditions. And, srGAP1 expression was decreased when Wnt signaling was inhibited by a Wnt antagonist Wnt-inhibitory factor-1 (WIF-1) in CRPC cell lines. Functional studies using chromatin immmunoprecipitation and luciferase assays were performed to examine whether Wnt transcription factor LEF-1 or TCF-4 binds and activates the srGAP1 promoter. Overexpression of WIF-1 inhibited the promoter activity of srGAP1. Taken together, our results indicated that srGAP1 is co-regulated by both Wnt and AR signaling and srGAP1 may be a new potential Wnt target gene in castration-resistance prostate cancer. Citation Format: Noriko N. Yokoyama, Toshinori Sakai, Zheng Sun, Shujuan Shao, Jiaoti Huang, Bang H. Hoang, Xiaolin Zi. Co-regulation of srGAP1 by Wnt and androgen receptor signaling in castration resistant prostate cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3314. doi:10.1158/1538-7445.AM2014-3314
Oral hydralazine therapy for chronic refractory heart failure.
Authors: K Chatterjee, W W Parmley, B Massie, B Greenberg, J Werner, S Klausner, A Norman
Journal: Circulation (1976)

The hemodynamic effects of oral hydralazine were investigated in ten patients (nine in NYHA Class IV and one in Class III) with chronic refractory heart failure. With hemodynamic monitoring, adequate oral doses of hydralazine (50 or 75 mg) were determined and then administered every six hours. Hemodynamics were determined at 2-3, 6-8 and 24 hours on hydralazine therapy. Arterial pressure decreased slightly (5%) and systemic vascular resistance decreased significantly (42%). Cardiac and stroke volume index increased by 70 and 66%, respectively, without any significant change in heart rate, pulmonary capillary wedge or right atrial pressure. Hemodynamic improvement was associated with clinical improvement without a major complication. During the follow-up period of 3-7 months, seven of nine patients were in NYHA Class II and one in Class III. One other patient died suddenly six weeks after discharge. These findings suggest that hydralazine in an effective oral vasodilator for the treatment of refractory heart failure.
Whither structured representation?
Authors: Arthur B. Markman, Eric Dietrich
Journal: Behavioral and Brain Sciences (1999)

The perceptual symbol system view assumes that perceptual representations have a role-argument structure. A role-argument structure is often incorporated into amodal symbol systems in order to explain conceptual functions like abstraction and rule use. The power of perceptual symbol systems to support conceptual functions is likewise rooted in its use of structure. On Barsalou's account, this capacity to use structure (in the form of frames) must be innate.
Drugs taken by mothers in the puerperium
Authors: C. M Passmore, J. C McElnay, P. F D'Arcy
Journal: BMJ (1985)

Serum lipid levels at admission (day 0), and 2, 4, 6, 8, 10, and 30 days after acute myocardial infarction.Results are means (and SD) Days: 0 2 4 6 8 10 30 Total cholesterol (mmol/l) 4 53 (1 08) 4 14 (1 00) 4-44 (1-11) 4-67 (1-09) 4-94 (1 08) 5 16 (1-13) 5 94 (143)* HDL cholesterol(mmol'l) 0-97 (0 23) 0-88 (0 21) 0 85 (0 17) 0 87 (0 12) 0-94 (0 14) 0-99 (0-16) 1 09 (0 17)tTriglycerides (mmol,il) 1-29 (0-52) 1-38 (0 63) 1-49 (0-80) 1.53 (0-64) 1 62 (0 75) 1 86 (0-96)$ 2 13 (112)+ *Significantly raised compared with admission p<00025.tSignificantly raised compared with fourth day after admission p < 0-01.$Significantly raised compared with admission p < 0 05.Conversion: SI to traditional units-Cholesterol: 1 mmol/l 38-6 mg!100 ml.Triglycerides: 1 mmol/I 88-5 mg/ 100 ml.
Infectious mononucleosis in children. Evaluation of Epstein-Barr virus-specific serological data
Authors: Charles M. Ginsburg, Werner Henle, Gertrude Henle, Charles A. Horwitz
Journal: JAMA (1977)

Epstein-Barr virus (EBV)-specific antibody responses were determined in 43 consecutive pediatric patients who had signs and symptoms of inectious mononucleosis (IM) and positive diagnostic tests for mononucleosis (Monspot). Thirty patients gave clear-cut serologic evidence of primary EBV infections; of the remaining 13 patients, seven had no antibodies to EBV in the acute- or convalescent-phase sera and six showed serologic patterns of past EBV infections. Further testing proved that the initial Monospot results were either false-positive or were incorrectly interpreted in all 13 patients with unidentifiable illnesses but in only two of the patients with current EBV infections. The data confirm the occurrence of classical IM in children and show that the disease and the EBV-specific antibody responses can be virtually indistinguishable from adult cases.
Arthritides Caused by Mosquito-Borne Viruses
Authors: R B Tesh
Journal: Annual Review of Medicine (1982)

Five different mosquito-borne viruses (chikungunya, o'nyong-nyong, Mayaro, Ross River, and Sindbis) have been associated with arthritis in humans. These agents occur most commonly in the tropics and subtropics. The symptoms they produce are similar and typically consist of fever, arthralgia, and rash. In general, the symptoms are of short duration (less than one week) and recovery is complete, although some patients have recurrent episodes of joint swelling and tenderness for months after infection. Treatment is symptomatic. There are no vaccines currently available; the best prevention is to avoid mosquito bites when traveling or living in areas where these diseases occur.
GPR84 sustains aberrant β-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis
Authors: Philipp A. Dietrich, Chen Yang, Halina H. L. Leung, Jennifer R. Lynch, Estrella Gonzales, Bing Liu, Michelle Haber, Murray D. Norris, Jianlong Wang, Jenny Yingzi Wang
Journal: Blood (2014)
Physiologic cardiac hypertrophy corrects contractile protein abnormalities associated with pathologic hypertrophy in rats.
Authors: J Scheuer, A Malhotra, C Hirsch, J Capasso, T F Schaible
Journal: Journal of Clinical Investigation (1982)

To evaluate the combined effects of cardiac overload imposed by hypertension and by chronic exercise, male and female rats were made hypertensive by unilateral renal artery stenoses and made to exercise in an 8-10-wk swimming program. Sedentary normotensive animals, sedentary hypertensive animals and normotensive animals exposed to the swimming program were also studied. Hypertension was associated with the development of cardiac hypertrophy, and this was exaggerated in hypertensive swimmers. Actomyosin, Ca2+-myosin, and actin-activated Mg2+-myosin ATPase activities were enhanced in normotensive swimmers, depressed in hypertensives and were normal or increased in hypertensive swimmers. Myosin isoenzyme analysis showed a predominant V1 pattern in normals; an increase in percent V1 isoenzyme is swimmers; a predominant V3 pattern in hypertensives; and a return to the predominant V1 pattern in hypertensive swimmers. These findings suggest that the hypertrophy imposed by hypertension and hypertrophy imposed by physical training using a chronic swimming program are distinctly different biological phenomena. Physical training by swimming prevents the changes in cardiac myosin induced by hypertension despite the exaggeration of hypertrophy.
The potential role of BMI, plasma leptin, nesfatin-1 and ghrelin levels in the early detection of pancreatic necrosis and severe acute pancreatitis: A prospective cohort study
Authors: Ahmet Türkoğlu, Abdullah Böyük, Mehmet Halis Tanrıverdi, Ercan Gündüz, Abdurrahim Dusak, İbrahim Kaplan, Metehan Gümüş
Journal: International Journal of Surgery (2014)
Counting Adverse Drug Reactions That Count
Authors: F.J. Ingelfinger
Journal: New England Journal of Medicine (1976)

Some cry, "Bad Prescriptions Kill Thousands a Year," and assert that 30,000 Americans die "as a direct result" of "the drugs their doctors prescribe for them."1 Others depreciate the seriousness of drug toxicity and point out that a drug-related fatality rate of 2.4 per thousand patients admitted to hospital medical services (24,000 patients in all) represents a small risk and that drugs, compared to many a daily hazard to which we are all exposed, are in general remarkably benign.2 A third faction decries the debate as useless on the grounds that valid data on the prevalence and incidence of adverse . . .
Abstract 2520: TAK-733, a novel MEK1/2 inhibitor, inhibits tumor angiogenesis without affecting vascular permeability
Authors: Hori Akira, Shuntarou Tsuchiya, Yuichi Kakoi, Akio Mizutani, Patrick Vincent
Journal: Cancer Research (2010)

Abstract TAK-733 is a highly potent, selective, and non-ATP competitive inhibitor of mitogen-activated protein kinase kinase 1/2 (MEK1/2). In preclinical studies, TAK-733 exhibits potent antitumor activity against a variety of human tumor xenografts, but does not affect vascular permeability. The effects of TAK-733 on tumor angiogenesis were investigated in this preclinical study. TAK-733 completely inhibited the vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)-induced ERK phosphorylation in human umbilical vein endothelial cells (HUVECs) at 100 nM. TAK-733 also inhibited VEGF- and FGF-induced HUVEC proliferation (IC50 = 1.3 and 18 nM, respectively) and HUVEC tube formation cocultured with fibroblasts (IC50 = 0.49 and 0.34 nM, respectively). The anti-angiogenic effect of TAK-733 in vivo was evaluated in a Matrigel plug assay following daily oral administration of TAK-733 at 3 and 10 mg/kg for 7 days. TAK-733 significantly inhibited the bFGF-induced hemoglobin accumulation in Matrigel plugs. TAK-733 significantly suppressed micro vessel density, examined by immunostaining with an anti-CD31 (PECAM) antibody, in human lung carcinoma A549 xenografts 4 and 7 days after initial treatment of 3 and 10 mg/kg. This was associated with significant antitumor effects in these xenograft models. These results indicate that potent anti-angiogenic activity of TAK-733 contributes to the anti-tumor activities. Angiogenesis inhibitors that modulate VEGF or VEGFR have all displayed hypertensive toxicity. Lack of nitric oxide production as a result of VEGF inhibition produces vasoconstriction and decreased vascular permeability leading to hypertensive effects (Fukumura et. al, PNAS 98, p2604, 2001). The effects of TAK-733 and VEGFR tyrosine kinase inhibitor on tumor interstitial fluid pressure (IFP) were examined by using wick-in-needle method in A549 xenograft model. TAK-733 did not affect the tumor IFP 6 hours after single administration of 30 mg/kg, while the VEGFR tyrosine kinase inhibitor significantly decreased it at 60 mg/kg. Consistent with the effects on tumor IFP, TAK-733 did show change of the vascular permeability unlike the VEGFR tyrosine kinase inhibitor by means of the Evans blue extravasation technique in A549 xenograft model. Although TAK-733 shows potent antiangiogenic effect, these profiles of TAK-733 on vascular permeability would not be expected to induce the typical toxicity of VEGF inhibitor. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2520.
Potential role of hepatocyte growth factor in the maintenance of renal structure: Anti-apoptotic action of HGF on epithelial cells
Authors: Yoshikage Yo, Ryuichi Morishita, Shigefumi Nakamura, Naruya Tomita, Kei Yamamoto, Atsushi Moriguchi, Kunio Matsumoto, Toshikazu Nakamura, Jitsuo Higaki, Toshio Ogihara
Journal: Kidney International (1998)