Granulomatous Nephritis as the First Manifestation of Whipple Disease
Authors: Isabelle Marie
Journal: Annals of Internal Medicine (2000)

Letters4 January 2000Granulomatous Nephritis as the First Manifestation of Whipple DiseaseIsabelle Marie, MD, Frédéric Lecomte, MD, and Hervé Levesque, MD, PhDIsabelle Marie, MDCentre Hospitalier Universitaire de Rouen-Boisguillaume; 76031 Rouen, France (Marie)Centre Hospitalier Universitaire de Rouen-Boisguillaume; 76031 Rouen, France (Lecomte)Centre Hospitalier Universitaire de Rouen-Boisguillaume; 76031 Rouen, France (Levesque)Search for more papers by this author, Frédéric Lecomte, MDCentre Hospitalier Universitaire de Rouen-Boisguillaume; 76031 Rouen, France (Marie)Centre Hospitalier Universitaire de Rouen-Boisguillaume; 76031 Rouen, France (Lecomte)Centre Hospitalier Universitaire de Rouen-Boisguillaume; 76031 Rouen, France (Levesque)Search for more papers by this author, and Hervé Levesque, MD, PhDCentre Hospitalier Universitaire de Rouen-Boisguillaume; 76031 Rouen, France (Marie)Centre Hospitalier Universitaire de Rouen-Boisguillaume; 76031 Rouen, France (Lecomte)Centre Hospitalier Universitaire de Rouen-Boisguillaume; 76031 Rouen, France (Levesque)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-1-200001040-00023 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Renal involvement is rare in Whipple disease (1, 2). It occurs late during the course of the disease (1, 2). We observed a patient who developed renal failure related to granulomatous nephritis. Polymerase chain reaction (PCR) analysis of 16S ribosomal RNA (rRNA) was positive in renal biopsy specimens, demonstrating the presence of Tropheryma whippelii(3).A 60-year-old man presented in April 1996 with an 8-month history of polyarthralgias involving the shoulders, elbows, wrists, and knees. The following laboratory findings were abnormal: erythrocyte sedimentation rate, 56 mm/h; protein level, 60 g/L; albumin level, 26 g/L; serum creatinine concentration, 239 ...References1. Durand DV, Lecomte C, Cathébras P, Rousset H, Godeau P. Whipple disease. Clinical review of 52 cases. The SNFMI Research Group of Whipple Disease. Société Nationale Française de Médecine Intern. Medicine Baltimore. 1997;76:170-84. CrossrefMedlineGoogle Scholar2. Dhib M, Heron F, Francois A, Bourreile J, Landrin I, Godin M. Kidney granuloma in Whipple's disease [Letter]. BMJ. 1993;307:1067-8. CrossrefMedlineGoogle Scholar3. Ramzan NN, Loftus E, Burgart LJ, Rooney M, Batts KP, Wiesner RH, et al . Diagnosis and monitoring of Whipple disease by polymerase chain reaction. Ann Intern Med. 1997;126:520-7. LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Centre Hospitalier Universitaire de Rouen-Boisguillaume; 76031 Rouen, France (Marie)Centre Hospitalier Universitaire de Rouen-Boisguillaume; 76031 Rouen, France (Lecomte)Centre Hospitalier Universitaire de Rouen-Boisguillaume; 76031 Rouen, France (Levesque) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRenal transplantation in AA amyloidosis associated with Whipple’s diseaseWhipple's disease: often a late diagnosis and a rare cause of nephropathy 4 January 2000Volume 132, Issue 1Page: 94-95KeywordsBiopsyCreatinineExcretionHistologyMycoplasma pneumoniaeNephritisRenal analysisRenal diseasesSerum proteinsSystemic diseases Issue Published: 4 January 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...