tbuckley/cabot-search huggingface dataset:
The Role of Regional Anesthesia in Decreasing Thromboembolism
Authors: Kenneth D. Larsen
Journal: JAMA (1989)

<h3>To the Editor.—</h3> Dr Coon<sup>1</sup>discusses the role of anticoagulants in decreasing the incidence of thromboembolism after total hip replacement, but he does not mention the contribution of anesthesia. Regional (spinal or epidural) anesthesia for orthopedic surgery significantly reduces the likelihood of thromboembolism compared with general anesthesia.<sup>2-4</sup>However, in the case of surgery for a fractured hip, the improvement fades over a period of months, when other unidentified factors equalize the mortality after general vs regional anesthesia.<sup>5</sup> There is a possibility of increased blood loss when anticoagulants are used to avoid thromboembolism; regional anesthesia also reduces blood loss and the need for transfusion.<sup>2</sup>For the patient in question for whom there might be difficulty in obtaining compatible blood, autologous donation of blood and a regional anesthetic should be considered as ways to decrease the risk of thromboembolism and the need for heterologous transfusion.
A new definition
Authors: P. Foot
Journal: BMJ (2000)

Gore Vidal told a wonderful joke on the radio recently about the former British prime minister Harold Macmillan and a social visit he paid with his wife to the then French president, Charles de Gaulle. At the end of a long and probably very boring meal, Macmillan turned to Madame de Gaulle and asked politely what she was looking forward …
Bacillary angiomatosis with cutaneous and oral lesions in an HIV-infected patient from the U.K.
Authors: N.J LEVELL, A.P BEWLEY, S. CHOPRA, D. CHURCHILL, P. FRENCH, R. MILLER, J.J.H. GILKES
Journal: British Journal of Dermatology (1995)

Journal Article Bacillary angiomatosis with cutaneous and oral lesions in an HIV‐infected patient from the U.K. Get access N.J LEVELL, N.J LEVELL Department of Dermatology, University College London Medical School. London W1N8AA, U.K. Search for other works by this author on: Oxford Academic Google Scholar A.P BEWLEY, A.P BEWLEY Department of Dermatology, University College London Medical School. London W1N8AA, U.K. Search for other works by this author on: Oxford Academic Google Scholar S. CHOPRA, S. CHOPRA Department of Dermatology, University College London Medical School. London W1N8AA, U.K. Search for other works by this author on: Oxford Academic Google Scholar D. CHURCHILL, D. CHURCHILL Department of Medicine, University College London Medical School. London W1N8AA, U.K. Search for other works by this author on: Oxford Academic Google Scholar P. FRENCH, P. FRENCH Department of Genitourinary Medicine, University College London Medical School. London W1N8AA, U.K. Search for other works by this author on: Oxford Academic Google Scholar R. MILLER, R. MILLER Department of Medicine, University College London Medical School. London W1N8AA, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.J.H. GILKES J.J.H. GILKES Department of Dermatology, University College London Medical School. London W1N8AA, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 132, Issue 1, 1 January 1995, Pages 113–115, https://doi.org/10.1111/j.1365-2133.1995.tb08634.x Published: 01 January 1995 Article history Accepted: 03 May 1994 Published: 01 January 1995
Is minimal change esophagitis really part of the spectrum of endoscopic findings of gastroesophageal reflux disease? A prospective, multicenter study
Authors: J. Kim, H. Park, Y. Lee
Journal: Endoscopy (2011)

See also: Commentaire de travail de J. H. Kim et al., pp. 190Endoscopy 2011; 43(03): 248-249DOI: 10.1055/s-0031-1291805
Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression
Authors: Hao Zhang, Jing Wei, Rong Xue, Jin-Dan Wu, Wei Zhao, Zi-Zheng Wang, Shu-Kui Wang, Zheng-Xian Zhou, Dan-Qing Song, Yue-Ming Wang, Huai-Ning Pan, Wei-Jia Kong, Jian-Dong Jiang
Journal: Metabolism (2009)
TCT-239 Does Adenosine Administration Improve Diagnostic Classification Of The Instantaneous Wave–Free Ratio (iFR)?
Authors: Sayan Sen, Kaleab Asrress, Ricardo Petraco, Sukhjinder Nijjer, Christopher Broyd, Nicolas Foin, Rodney Foale, Iqbal Malik, Ghada Mikhail, Amarjit Sethi, Masood Khan, Muhammed Khawaja, Alun Hughes, Darrel Francis, Christopher Baker, Jamil Mayet, Carlo Di Mario, Javier Escaned, Simon Redwood, Justin Davies
Journal: Journal of the American College of Cardiology (2012)
Chronic Nail Pigmentation in a 50-Year-Old Woman
Authors: Gary N. Fox
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
De subitaneis mortibus. XIX. On the cause of sudden death in pheochromocytoma, with special reference to the pulmonary arteries, the cardiac conduction system, and the aggregation of platelets.
Authors: T N James
Journal: Circulation (1976)

Pheochromocytoma may cause sudden and unexpected death. In this study of three fatal cases of pheochromocytoma the small pulmonary arteries were narrowed by a variety of chronic and acute processes which included medial hypertrophy and fibrosis, endothelial proliferation and fibrosis, and endothelial cellular edema; within the sinus node, atrioventricular (A-V) node and His bundle of all three cases there was focal degeneration and fibrosis similar to that also observed throughout the ventricular myocardium; and in addition to the focal narrowing of many small coronary arteries produced by medial hypertrophy, intimal fibrosis, and fibromuscular dysplasia, there were also focal aggregations of platelets clogging the lumen and occasionally mixed with a varying amount of fibrin. In patients known to have pheochromocytoma it may be necessary to direct new attention to the possibility of abnormal pulmonary vascular resistance, instability of normal cardiac rhythm, and perhaps difficulty in restoring it when disordered and to the effects of platelet aggregations, both causing acute obstruction and possibly contributing to the pathogenesis of chronic vascular disease.
Significance of IgM anti-HCVcore level in chronic hepatitis C
Authors: George V. Papatheodoridis, Johanna K. Delladetsima, Antigoni Katsoulidou, Vana Sypsa, Monika Albrecht, Gerd Michel, Angelos Hatzakis, Nicolaos C. Tassopoulos
Journal: Journal of Hepatology (1997)
1060 ECONOMIC EVALUATION OF A MULTIDISCIPLINARY SUPPORT PROGRAM IN HEPATITIS C TREATMENT: PRELIMINARY RESULTS
Authors: M. García-Retortillo, V. Martín-Escudero, M.D. Giménez, I. Cirera, C. Márquez, P. Castellví, O. Urbina, E. Salas, C. Varela, R. Solà
Journal: Journal of Hepatology (2010)
An Addisonian goose chase
Authors: J. L Walker, S. E R S Stanaway
Journal: BMJ (2009)

This started as a chance inquiry from one of our patients who was alarmed to read the following in her patient information leaflet (PIL) for a particular brand of folic acid: “Do not take folic acid tablets if you have Addison’s disease.”

This puzzled the endocrinologist and further puzzled the clinical pharmacist as we knew of no such contraindication. The first clue came after we contacted the pharmaceutical company in question, which “reassured” us that “the wording is more explanatory” in the data sheet. This stated: “Folic acid should never be given alone in the treatment …
European guidelines for quality assurance in colorectal cancer screening and diagnosis. – First Edition Faecal occult blood testing
Authors: S. Halloran, G. Launoy, M. Zappa
Journal: Endoscopy (2012)

Multidisciplinary, evidence-based guidelines for quality assurance in colorectal cancer screening and diagnosis have been developed by experts in a project coordinated by the International Agency for Research on Cancer. The full guideline document covers the entire process of population-based screening. It consists of 10 chapters and over 250 recommendations, graded according to the strength of the recommendation and the supporting evidence. The 450-page guidelines and the extensive evidence base have been published by the European Commission. The chapter on faecal occult blood testing includes 21 graded recommendations. The content of the chapter is presented here to promote international discussion and collaboration by making the principles and standards recommended in the new EU Guidelines known to a wider professional and scientific community. Following these recommendations has the potential to enhance the control of colorectal cancer through improvement in the quality and effectiveness of screening programmes and services.
NHS puts brake on roll-out of summary care records
Authors: M. Cross
Journal: BMJ (2010)

The NHS in England is insisting that its scheme to computerise the health records of all patients will go ahead despite the suspension of work in five strategic health authorities after concerns about “professional and public awareness.”

Connecting for Health, the NHS’s IT agency, said that it had halted the uploading of summary care records in five “accelerated roll-out areas,” covering 70 primary care trusts, where strategic health authorities were informing patients of their right to opt out of the programme.

However, it said that in 16 areas where primary care trusts …
Does the Phosphate Binder Lanthanum Carbonate Affect Bone in Rats with Chronic Renal Failure?
Authors: Geert J. Behets, Geert Dams, Sven R. Vercauteren, Stephen J. Damment, Roger Bouillon, Marc E. De Broe, Patrick C. D’Haese
Journal: Journal of the American Society of Nephrology (2004)

ABSTRACT. Adequate control of phosphate levels remains an important issue in patients with chronic renal failure (CRF). Lanthanum carbonate has been proposed as a new phosphate binder. Previous studies have shown a high phosphate binding capacity (>97%) and low gastrointestinal absorption of lanthanum, without serious toxic side effects in the presence of a normal renal function (NRF). Because of lanthanum’s physicochemical resemblance to calcium, the possible effects of it on bone have to be considered. The aim of this study was to investigate the effects of lanthanum carbonate on bone histology in NRF and CRF rats after oral administration of the compound with doses of 100, 500, or 1000 mg/kg per d for 12 wk. Bone histomorphometry showed that CRF animals that received vehicle developed secondary hyperparathyroidism. Urinalysis of lanthanum-loaded CRF animals showed a dose-dependent decrease in urinary phosphorus excretion, which was clearly more pronounced in the CRF groups compared with NRF animals. Phosphatemia, however, remained normal. Lanthanum carbonate administration induced a dose-dependent decrease in bone formation rate and increase in osteoid area in CRF animals. Three of seven animals in the CRF-1000 group and one of eight animals in the NRF-100 group were classified as having a mineralization defect. The number of cuboidal osteoblasts, however, was not affected, indicating that bone changes were not due to a toxic effect of lanthanum on the osteoblast. Furthermore, lanthanum concentrations in the femur remained low and did not correlate with histomorphometric parameters. These findings suggest that the administration of high doses of phosphate binder (1000 mg/kg per d lanthanum carbonate), in combination with decreased 25-(OH) vitamin D3 in the uremic state, resulted in phosphate depletion and followed by an increased mobilization of phosphorus out of bone and/or reduced incorporation into bone. There was no evidence that lanthanum had a direct toxic effect on osteoblasts.
Mitral valve replacement with stored inverted pulmonary homograft valve
Authors: J. Somerville, D. Ross, J. K. Ross
Journal: Thorax (1972)

The fate is described of 11 patients who had a stored pulmonary valve homograft mounted on a frame or in a Dacron jacket used for mitral valve replacement. Mitral regurgitation due to holes in the attenuated cusps occurred in nine by one year, requiring re-operation or causing death. Only one patient remains well with moderate mitral regurgitation after two years. Since January 1967, 118 patients have had mitral valve replacement with a preserved cadaver semilunar homograft valve mounted in a jacket or frame (Murray, Roschlau, and Lougheed, 1956; Heimbecker <i>et al.</i>, 1962). In all except 11 patients the aortic valve was used. However, in the 11 patients in whom an inverted pulmonary valve was used (Lower, Stofer, and Shumway, 1961) the clinical course has been different. The purpose of this report is to draw attention to the problems and discourage the use of this form of mitral valve replacement.
Marketing infant formulas
Authors: F. Falkner
Journal: BMJ (1993)

<b>Background:</b> The indication of chest physical therapy as an adjunct to treatment of children hospitalized with acute pneumonia remains controversial and there is lack of robust scientific evidence on effectiveness of this modality in these patients. <b>Methods:</b> A randomized controlled trial was conducted in two tertiary hospitals in southern Brazil. Children aged 29 days to 12 years, hospitalized with pneumonia between February and October of 2006 were recruited. Fifty-one patients were randomly allocated to the intervention group (chest physical therapy plus standard treatment for pneumonia) and 47 to the control group (standard treatment for pneumonia alone). The primary outcome was time to clinical resolution. The secondary outcomes were length of hospitalization and duration of respiratory symptoms and signs. <b>Results:</b> There were no significant differences in terms of median time to clinical resolution (4.0 vs 4.0 days, p=0.84) and median length of hospital stay (6.0 vs 6.0 days, p=0.76) between the intervention and control groups. The intervention group had longer median duration of coughing (5.0 vs 4.0 days, p=0.04) and of rhonchi in lung auscultation (2.0 vs 0.5 days, p=0.03) than the control group. <b>Conclusions:</b> Chest physical therapy as adjunct to the standard treatment does not hasten clinical resolution of children hospitalized with acute pneumonia and may prolong duration of coughing and rhonchi.
Antinative DNA antibodies as a reaction to pyrazole drugs.
Authors: M F Grayson, V M Martin, R L Markham
Journal: Annals of the Rheumatic Diseases (1975)

A case history is presented of the occurrence of a high binding capacity for native DNA in the serum of a patient on phenylbutazone. This reverted to normal on stopping the drug. The patient also had a reversible neutropenia and leucopenia, and it is suggested that the high anti-DNA binding capacity was a feature of a drug-induced lupus-like phenomenon.
Assessing the impact of population stratification on genetic association studies
Authors: Matthew L Freedman, David Reich, Kathryn L Penney, Gavin J McDonald, Andre A Mignault, Nick Patterson, Stacey B Gabriel, Eric J Topol, Jordan W Smoller, Carlos N Pato, Michele T Pato, Tracey L Petryshen, Laurence N Kolonel, Eric S Lander, Pamela Sklar, Brian Henderson, Joel N Hirschhorn, David Altshuler
Journal: Nature Genetics (2004)
RETROVERSION OF THE UTERUS TREATED BY GILLIAM'S ROUND LIGAMENT VENTRISUSPENSION: With an Analysis of 100 Consecutive Cases
Authors: F. Ivens
Journal: BMJ (1912)

BRTTSW 81 suffer fronm attacks of complete obstrtuction with vomniting anid d-uxring tlle interval the patient feels quite well.You'i mInust therefore keep in mind that the raisin test to wlhich I lhave referred does not give information regarding partial stenosis of the pylorus unless used during an attack, but the fact that youi have recurrelnt attacks ouighlt to make.youl recomnmend a gastro-enterostom1y.Keep in iminid that tetany or a sliglht epileptic attack occurs iu som-le cases, and in these an operation is essential.In the 8 reemaining cases, 3 were for iualigiiant disease.2 partial gastrectomies with gastro-enterostomty. the tlhird a siInI)le gastro-enterostomy.One of the gastrectom-lies, dlone three years ago, is still quite wvell; the otlher one died at the end of four months fromi secondary growths all over the inside of the abdomnen, with ascites; tlhe third case lived for siximonths.The, atoniec cases. 4in niiiiber, were the imost dis- appointing.Perseverance in carefuil dieting anid other treatmnenit generally, however, gives a satisfactory result.The only case unaccounted for in otur last list of 81 is of great initerest.Ten years ago I operate(l for a tiiptired gastric ulcer in the body of the stomiiach, from wilieli the patient recovered.She was sent back to hospital witlh s;evere liaemiorrhage, from which I feared she woulld die, but, aided by adrenalin an(d normal horse serui, she recovered sufficiently to enable ie to p( ri orm agastro-gastrostormiy.I could not in this case do a double gastro-enterostonmy.She continuies to be quite well, eighteen months after the ,operation.Youi will tlhtus see that the percentage of deaths is not large, being 5 per cent. in the 81 cases.Looking at all the facts now before us I feel satisfied that youi may reconimend gastro-enterostomiiy as a safe and satisfactory operation.I think there is a tendency to persevere too long with medical treatmlent, and you wouil(d do well to recomm-lend earlier operatioin, more especially in cases of mnalianancy.
THE DIFFERENT TYPES OF DEFECTS OF THE FIELD OF VISION
Authors: HENNING RØNNE
Journal: JAMA (1927)

Among the most frequent and characteristic types of defects of the field of vision is the so-called defect in the bundle of nerve fibers which arises as a consequence of the course of the nerve fibers across the retina. From the nasal half of the papilla they extend radially, whereas from the upper and lower edge they extend in large curves above and below the macula. The upper and lower bundles of nerve fibers meet in the temporal part of the retina. The horizontal meridian is a rectilinear "raphe" which from the macula extends quite out to the temporal meridian of the retina (fig. 1). If, now, such a bundle is injured, for example, at the edge of the papilla, a defect will appear corresponding to the whole section of the retina which is served by the respective bundle, and the defect will therefore have the form of the projection
Remission, relapse, and re-remission of proliferative lupus nephritis treated with cyclophosphamide
Authors: John P.A. Ioannidis, Kyriaki A. Boki, Maria E. Katsorida, Alexandros A. Drosos, Fotini N. Skopouli, John N. Boletis, Haralampos M. Moutsopoulos
Journal: Kidney International (2000)
Mindfulness in Medicine
Authors: David S. Ludwig
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anticonvulsant Drug Blood Levels
Authors: Samuel Livingston
Journal: JAMA (1975)

WITHIN recent years, sophisticated techniques for measuring anticonvulsant drug serum levels have been developed.<sup>1</sup>The use of such procedures constitutes a major advancement in the medical management of the patient with epilepsy. The purposes of this report are to present (1) data relative to the therapeutic and toxic blood level ranges of phenobarbital and diphenylhydantoin (Dilantin), and (2) the significant and practical indications for determination of anticonvulsant-drug levels in the blood. <h3>Determinations of Drug Levels in the Blood</h3> Clinical response remains the most important criterion in regulating the dosage of antiepileptic medication. However, we have found drug blood level determinations to be helpful in the management of some patients, particularly those who do not respond to average or maximal doses or who manifest signs or symptoms of toxicity while receiving small or conventional dosages of anticonvulsant agents. We have performed thousands of serial diphenylhydantoin and phenobarbital blood level determinations
Extraosseous Uptake of Tc-99m HDP in Muscular Dystrophy
Authors: PETER J. NYE, JACOB A. AELION, SATISH K. ODHAV, SHONDRA BAIN
Journal: Clinical Nuclear Medicine (2000)

A 43-year-old woman with muscular dystrophy was admitted for sudden onset of rhabdomyolysis and myoglobinuria. Serum creatine phosphokinase levels peaked at 230,000 U/l. Her family history was positive for muscle carnitine palmityl transferase deficiency, with episodic myoglobinuria in a sister. The results of a workup for toxic, infectious, and inflammatory myopathic causes were negative. A whole-body bone scan was performed. Treatment consisted of bed rest and fluids, with resolution of her symptoms and abnormal laboratory findings within 3 weeks. Bizarre extraosseous uptake with bone scintigraphy has been documented in cases of rhabdomyolysis caused by drugs and strenuous activity.
No Role for Routine Chest Radiography in Stage I Seminoma Surveillance
Authors: Shaun Tolan, Danny Vesprini, Michael A.S. Jewett, Padraig R. Warde, Martin O’Malley, Tony Panzarella, Jeremy F.G. Sturgeon, Malcolm Moore, Betty Tew-George, Mary K. Gospodarowicz, Peter W.M. Chung
Journal: European Urology (2009)