tbuckley/cabot-search huggingface dataset:
Myeloperoxidase and Plasminogen Activator Inhibitor 1 Play a Central Role in Ventricular Remodeling after Myocardial Infarction
Authors: Arman T. Askari, Marie-Luise Brennan, Xiaorong Zhou, Jeanne Drinko, Annitta Morehead, James D. Thomas, Eric J. Topol, Stanley L. Hazen, Marc S. Penn
Journal: The Journal of Experimental Medicine (2003)

Left ventricular (LV) remodeling after myocardial infarction (MI) results in LV dilation, a major cause of congestive heart failure and sudden cardiac death. Ischemic injury and the ensuing inflammatory response participate in LV remodeling, leading to myocardial rupture and LV dilation. Myeloperoxidase (MPO), which accumulates in the infarct zone, is released from neutrophils and monocytes leading to the formation of reactive chlorinating species capable of oxidizing proteins and altering biological function. We studied acute myocardial infarction (AMI) in a chronic coronary artery ligation model in MPO null mice (MPO−/−). MPO−/− demonstrated decreased leukocyte infiltration, significant reduction in LV dilation, and marked preservation of LV function. The mechanism appears to be due to decreased oxidative inactivation of plasminogen activator inhibitor 1 (PAI-1) in the MPO−/−, leading to decreased tissue plasmin activity. MPO and PAI-1 are shown to have a critical role in the LV response immediately after MI, as demonstrated by markedly delayed myocardial rupture in the MPO−/− and accelerated rupture in the PAI-1−/−. These data offer a mechanistic link between inflammation and LV remodeling by demonstrating a heretofore unrecognized role for MPO and PAI-1 in orchestrating the myocardial response to AMI.
STUDIES ON THE PSITTACOSIS-LYMPHOGRANULOMA GROUP
Authors: Emma G. Allen, Anthony J. Girardi, M. Michael Sigel, Morton Klein
Journal: The Journal of Experimental Medicine (1953)

The findings presented indicate that aureomycin could become associated with tissue of the chick embryo by both hematogenous distribution and direct adsorption. Treatment of chick embryos infected with MP virus with 1 mg. of aureomycin by the allantoic route caused an inhibition of virus growth in the allantoic membrane. The drug had no effect on "inert" virus, and appeared to have little effect on adsorption of virus to host tissue. Complete inhibition of growth during the time interval corresponding to the first cycle of multiplication could be achieved only if the drug was administered within 6 to 8 hours after virus inoculation. Partial inhibition of virus multiplication could be achieved even if the administration was delayed as late as 24 hours after infection. In these experiments the chief role of the antibiotic appeared to be one of virustasis reflected in a prolongation of the latent period (non-infectious phase). The virus was able to resume its growth when a critical low level of the drug in the allantoic membrane was reached. When infectivity titrations were carried out using various tissues and organs of treated and untreated embryos, it was found that no virus was detectable in the brains of treated embryos as late as 192 hours after inoculation of virus. This was in contrast with the findings in allantoic membranes and livers of such embryos; these organs showed virus at 120 and 144 hours, respectively. In untreated controls, virus appeared in membranes at 24 hours, in the liver at 48 hours, and in the brain at 72 hours.
Effect of Oral and Inhaled Sodium Cromoglycate in Exercise–Induced Asthma
Authors: Ronald Dahl, Jørn Mølgaard Henriksen
Journal: Allergy (1980)

Ten patients with bronchial asthma reacting with bronchoconstriction after exercise were studied to compare the effect of oral sodium cromoglycate against sodium Cromoglycate inhalation and placebo. Only sodium cromoglycate inhalations protected against exercise‐induced asthma. The effect of sodium cromoglycate seems to be a local action of mucosal surfaces.
RELAPSING PUSTULAR ERUPTIONS OF THE HANDS AND FEET.
Authors: P. J. C. ASHURST
Journal: British Journal of Dermatology (1964)

Journal Article RELAPSING PUSTULAR ERUPTIONS OF THE HANDS AND FEET. Get access P. J. C. ASHURST, M.B., Ch.B. P. J. C. ASHURST, M.B., Ch.B. Registrar, Manchester and Halford Hospital for Skin Diseases, Quay Street, Manchester 3 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 76, Issue 4, 1 April 1964, Pages 169–180, https://doi.org/10.1111/j.1365-2133.1964.tb14502.x Published: 01 April 1964
Safe Uses of Cholestyramine
Authors: H. R. CASDORPH
Journal: Annals of Internal Medicine (1970)

Letters and Comments1 May 1970Safe Uses of CholestyramineH. R. CASDORPH, M.D., PH.D.H. R. CASDORPH, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-759 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I have read with interest the article, "Hypoprothrombinemia and Hemorrhage Associated with Cholestyramine Therapy," by Gross and Brotman (Ann Intern Med 72:95-96, 1970). It is perhaps noteworthy that this is the first reported hemorrhagic complication from this drug, which has been used for over 10 years.A historical overview seems indicated. Cholestyramine was initially developed to relieve the pruritus associated with partial biliary obstruction usually in patients with primary biliary cirrhosis. The concern with prothrombin production was logical since prothrombin is produced in the liver, and most of the first patients to be treated with this drug...Reference1. HOFMANNPOLEY AJ: Cholestyramine treatment of diarrhea associated with ileal resection. New Eng J Med 281: 397-402, 1969 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: H. R. CASDORPH, M.D., PH.D.Affiliations: Lipid Research Foundation 1729 Termino Ave. Long Beach, Calif. 90804 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySevere fetal intracranial haemorrhage during treatment with cholestyramine for intrahepatic cholestasis of pregnancyIntestinal Absorption of the Fat-Soluble Vitamins: Physiology and PharmacologyThe Single Dose Method of Administering CholestyramineIn Vitro Binding of Drugs to Colestipol HydrochlorideEffects of colestipol hydrochloride (U-26,597A) on serum and fecal lipids in dogs 1 May 1970Volume 72, Issue 5Page: 759-760KeywordsDrugsHemorrhageLiverPrimary biliary cirrhosisPruritus ePublished: 1 December 2008 Issue Published: 1 May 1970 PDF downloadLoading ...
Splenic infarction and tissue accumulation of crystals associated with the use of clofazimine (Lamprene; B663) in the treatment of pyoderma gangrenosum
Authors: A. C. McDOUGALL, W. R. HORSFALL, J. E. HEDE, A. J. CHAPLIN
Journal: British Journal of Dermatology (1980)

A male patient aged 68 years, suffering from pyoderma gangrenosum which was resistant to conventional treatment, received clofazimine 400 mg daily for 5 months, then reducing to 300 mg daily for the next 6 months. Eleven months after starting the drug, he was admitted to hospital with severe abdominal pain, laparotomy revealing infarction of the spleen, with violaceous congestion of the small bowel. The spleen was removed and post-operative recovery was satisfactory. Histopathological examination of the spleen (removed at operation) and of tissue from a duodenal biopsy (taken postoperatively) showed large numbers of striations and outlines suggestive of crystal deposition. Mesenteric lymph node revealed a massive accumulation of crystals in cortical and medullary sinuses. The findings emphasize that clofazimine should not be used in high dosage over prolonged periods of time, except under close clinical and laboratory supervision, and for conditions not amenable to other drugs.
THE TREATMENT OF WOUNDS IN WAR
Authors: E. G. Kennedy
Journal: BMJ (1915)

Description of Specimen;'The specimen removed shows a large sac-even now, after shrinkage' in preservative, fully 1l in. in diameter-which pro- jects into and distends the sterno-mastoid muscle on the one hand, and on the other comes'to within a quarter of an inch from the skin surface.The portion of the aneurysm in the muscle presents a distinct sac wall, composed of the dilated coats of the vessels, while that which projects toward the skinl surface has no true wall, and is occupied by a dark red thrombus.In this case, as in tlle last, wllil'e there is a perfectly distinct' history of wounding, no metal was found, either by x-ray examination or at the operation.Thle presump.tion is, tbe'refore, that the penetrating fragment was a very small one, and so was overlooked.It is possible, however, that it penetrated quite beyond the area examin'ed.The complex nature of the aneurysm will be noted, that part whiclh projected into the sterno- mastoid muscle lhaving a true sac wall derived from the coats of the damaged and distended ve'ssels, while thle portion whichi projected toward the skin was of tlle purely traumatic type, there being no true sac wall.It is remarkable that this rnan should hbave suffered sucl grave injury to his carotid artery, internal jugular vein, and vagus nerve, and yet lhave complained only of hleadache due to the thlrobbing of the aneurysm.So far as he is aware, he never lost consciousness.It is significant of the changes in methods of warfare that 'while the two cases-reported above were caused by shrapnel, the -patient in Case iii was wounded by a rifle bullet.CASE III.-Traumatic Femoral Aneurysm.T. B., a Boer, was shot on February.8th, 1900,the bullet, pre- sumably a Lee Metford, entering the thigh at the junction of the middle and lower thirds of the femur, in the line of the femoral artery, and coming out about 6 in.higher up, on the outside of the thigh.The wounds of entrance and exit were alike in appearance.The patient was brought to the Military Stationary Elospital, Orange River, where I was stationed as a civil surgeon, on April 8th, 1900, and placed under mny care.The history given was that he had been supposed to be suffering from fracture of the femur, with great throwing out of callus, and that he had been treated by massage without effect.
Serum-Therapy in Leprosy.
Authors: Albert L. Ashmead
Journal: JAMA (1895)

New York, Nov. 21, 1895. <h3>To the Editor:</h3> —Mr. Luther F. McKinney, United States Minister in Bogota, writes me (Oct. 17, 1895): "I enclose an article written by Dr. Putnam of this city, in which I know you will be interested. Dr. Putnam has taken a great interest in the subject of leprosy and, as you will see, believes in the theory that the disease can be cured by the injection of the blood of an animal previously inoculated with the serum from the blood of a leprous patient. He has one patient, a woman here in Bogota, whom he has been treating in this way for about four months. When she began there was an entire loss of sensibility of the arms and lower limbs, and large leprous blotches or sores on her arm. She has entirely recovered the sensibility of the arms, but not of the lower limbs;
An Interesting Case.
Authors: A. H. Tufts
Journal: JAMA (1898)

Sioux Falls, S. Dak., Dec. 27, 1897. <h3>To the Editor:</h3> —Christmas eve two men engaged in a quarrel in a saloon in this city over a bill. They went out into the street to continue the quarrel. After some words, the larger of the two, who was a large powerful man, struck the other a severe blow in the mouth. Instead of falling backward as would have been expected, the man hit fell forward and his enemy struck him another blow as he went down. He immediately became unconscious, and though his heart was beating when medical aid reached him, respiration had ceased and he was shortly pronounced dead. All sorts of conjectures were indulged in as to the probable cause of death, it not being thought probable that two such blows as were given could kill a man. Some attributed it to heart disease, others thought his neck must
Chemical exposure and intestinal function.
Authors: C M Schiller
Journal: Environmental Health Perspectives (1979)

The particular substances that are ingested by individuals are the consequence of their environmental, residential, and occupational exposures. The possible effects of these exposures on intestinal functions can be examined by the evaluation of in vivo or in vitro exposure followed by an in vivo and/or in vitro monitoring of effects. Several examples of the in vivo exposure and in vitro monitoring approach are presented to demonstrate the consequences of oral exposure to either a heavy metal (arsenic), or a herbicide contaminant (2,3,7,8-tetrachlorodibenzo-p-dioxin) or a jet fuel propellant (hydrazine) and the subsequent measurement of either a particular metabolic pathway, or a cell-specific enzyme induction or the development of brush border enzymes are presented.
Intracerebral Hemorrhage — Improving Outcome by Reducing Volume?
Authors: Stanley Tuhrim
Journal: New England Journal of Medicine (2008)

Intracerebral hemorrhage accounts for 10 to 15% of all strokes. It is the type of stroke with the highest mortality, with a 1-year survival rate of less than 50%.1 Most intracerebral hemorrhages occur in patients who have hypertension, which is the major modifiable risk factor for the occurrence of intracerebral hemorrhage.2 Although improvements in the early recognition and general intensive care of patients with intracerebral hemorrhage have been associated with decreased mortality, no specific intervention has proved efficacious. Mayer and colleagues, having previously reported encouraging results of a phase 2 trial in the Journal, 3 in this issue report disappointing results . . .
Monoclonality of parathyroid tumors in chronic renal failure and in primary parathyroid hyperplasia.
Authors: A Arnold, M F Brown, P Ureña, R D Gaz, E Sarfati, T B Drüeke
Journal: Journal of Clinical Investigation (1995)

The pathogeneses of parathyroid disease in patients with uremia and nonfamilial primary parathyroid hyperplasia are poorly understood. Because of multigland involvement, it has been assumed that these common diseases predominantly involve polyclonal (non-neoplastic) cellular proliferations, but an overall assessment of their clonality has not been done. We examined the clonality of these hyperplastic parathyroid tumors using X-chromosome inactivation analysis with the M27 beta (DXS255) DNA polymorphism and by searching for monoclonal allelic losses at M27 beta and at loci on chromosome band 11q13. Fully 7 of 11 informative hemodialysis patients (64%) with uremic refractory hyperparathyroidism harbored at least one monoclonal parathyroid tumor (with a minimum of 12 of their 19 available glands being monoclonal). Tumor monoclonality was demonstrable in 6 of 16 informative patients (38%) with primary parathyroid hyperplasia. Histopathologic categories of nodular versus generalized hyperplasia were not useful predictors of clonal status. These observations indicate that monoclonal parathyroid neoplasms are common in patients with uremic refractory hyperparathyroidism and also develop in a substantial group of patients with sporadic primary parathyroid hyperplasia, thereby changing our concept of the pathogenesis of these diseases. Neoplastic transformation of preexisting polyclonal hyperplasia, apparently due in large part to genes not yet implicated in parathyroid tumorigenesis and possibly including a novel X-chromosome tumor suppressor gene, is likely to play a central role in these disorders.
The Patient in Shock - Clinical Picture and Pathophysiology
Authors: G.E. Vogel
Journal: Endoscopy (1986)

The diagnosis of hemorrhagic shock can be made on the basis of a good knowledge of the clinical picture of the bleeding patient. The necessary lab tests must be carried out over a period of time to establish their evolution and thus the degree of shock. At present, attention is being focused on the microcirculation. In shock, tissue is starved of oxygen and nutrients, resulting in the liberation by degenerating cell structures of numerous substances that have an effect on vascular tone. Decompensation is accompanied by consumption coagulopathy, which also has an influence on the microcirculation. The inhibitor potential is very important here. The patient must be out of shock before endoscopy can be considered.
Multicenter Study of Autologous Adrenal Medullary Transplantation to the Corpus Striatum in Patients with Advanced Parkinson's Disease
Authors: Christopher G. Goetz, C. Warren Olanow, William C. Koller, Richard D. Penn, David Cahill, Robert Morantz, Glenn Stebbins, Caroline M. Tanner, Harold L. Klawans, Kathleen M. Shannon, Cynthia L. Comella, Thomas Witt, Michael Waxman, Lisa Gauger
Journal: New England Journal of Medicine (1989)

In 19 patients with severe Parkinson's disease, we replicated the surgical procedures developed by Madrazo et al. for transplantation of the adrenal medulla to the striatum, and followed them for six months after operation. We monitored their motor function with the use of standardized scales and determined the amount and quality of "on" and "off" time (the hours of the waking day when the anti-parkinsonism medications were effective and ineffective, respectively). We found significant improvement in focal areas of motor function. The mean percentage of on time during the day increased from 47.6 percent to 75.0 percent (P = 0.012); the mean percentage of on time without chorea increased from 26.6 percent to 59.2 percent (P = 0.006); the mean severity of off time decreased as assessed by both the Activities of Daily Living subscale of the Unified Parkinson's Disease Scale (P = 0.002) and the Schwab and England scale (P = 0.037). In contrast to the finding of Madrazo et al., however, the dosages of anti-parkinsonism medications could not be decreased and postoperative morbidity was substantial. Despite cautious optimism, we conclude that the wide-spread use of this procedure outside of research centers is premature, since the improvement we found was slighter than in the previous cases. (N Engl J Med 1989; 320: 337–41.)
Salient Features of Staphylococcus aureus Endocarditis.
Authors: Chatrchai Watanakunakorn
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Salient Features of Staphylococcus aureus Endocarditis.Chatrchai Watanakunakorn, M.D., James S. Tan, M.D., John P. Phair, M.D.Chatrchai Watanakunakorn, M.D.Search for more papers by this author, James S. Tan, M.D.Search for more papers by this author, John P. Phair, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-873_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStaphylococcus aureusendocarditis, a life-threatening disease in spite of the availability of antimicrobial therapy, is uniformly fatal if therapy is delayed. The clinical presentation and outcome of this disease over a period of 3 decades (1941 to 1971) were evaluated. Sixty-four cases were reviewed. In 10 cases (seven patients did not have a murmur and fever) antemortem blood cultures were not obtained, and the diagnosis was made at autopsy. All except one of these 10 patients were in their seventh, eighth, or ninth decade of life. Of the remaining 54 patients, only 21 survived. Survivors manifested slow clinical improvement with... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cincinnati, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInfectious diseases: annual review of significant publications. 1 May 1972Volume 76, Issue 5Page: 873-873KeywordsAntimicrobialsAutopsyBloodEndocarditisFeversStaphylococcus aureus Issue Published: 1 May 1972 PDF downloadLoading ...
Cost of Cancer Care: The Patient Perspective
Authors: Paula Kim
Journal: Journal of Clinical Oncology (2007)

The diagnosis of cancer, along with subsequent related care, imposes a number of burdens on patients—physical, emotional, and financial. The financial expenses incurred extend well beyond the cost of medication, surgery, and related treatments. While these important issues warrant attention, patients also need assistance dealing with the indirect costs of cancer care, such as transportation, child care, and lost wages. There is an urgent need to improve the current inconsistent—sometimes nonexistent—methods used to inform patients about costs of cancer care as well as to provide them with appropriate assistance managing the costs and overall burden of cancer. Health care providers, patient advocates, agencies, and insurers have the responsibility and opportunity to provide leadership in this process. Most importantly, limited ability to address any of the expenses brought on by cancer should not prevent any patient from receiving necessary care.
Orchitis as Complication of Chicken-pox
Authors: G. Ormiston
Journal: BMJ (1953)

GOATS' MILK IN ECZEMA MEDICALJOHAL 20 normal as possible (these were never far from some fairly typical eczematization).Readings were taken after 24, 48, and 72 hours.Conclusion Under the conditions of the trial, goats' milk, as such, had no effect on the course of the eczema in nine children.None of these patients showed cutaneous hypersensitivity with scratch or patch testings to cows' or goats' milk.We wish to thank Dr. J. T. Ingram and Dr. F. F. Hellier for their inspiration, encouragement
Alterations in regional myocardial distribution and arrhythmogenic effects of aprindine produced by coronary artery occlusion in the dog
Authors: S. NATTEL, D. H PEDERSEN, D. P ZIPES
Journal: Cardiovascular Research (1981)

Journal Article Alterations in regional myocardial distribution and arrhythmogenic effects of aprindine produced by coronary artery occlusion in the dog Get access STANLEY NATTEL, STANLEY NATTEL * From the Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, and the Veterans Administration Medical Center, Indianapolis, Indiana *Fellow of the Medical Research Council of Canada. Search for other works by this author on: Oxford Academic PubMed Google Scholar DONAL H PEDERSEN, DONAL H PEDERSEN From the Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, and the Veterans Administration Medical Center, Indianapolis, Indiana Search for other works by this author on: Oxford Academic PubMed Google Scholar DOUGLAS P ZIPES DOUGLAS P ZIPES From the Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, and the Veterans Administration Medical Center, Indianapolis, Indiana Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 15, Issue 2, February 1981, Pages 80–85, https://doi.org/10.1093/cvr/15.2.80 Published: 01 February 1981
337 THE ONCOLYTIC ADENOVIRUS ADP53-SENSOR FOR SELECTIVE REPLICATION IN P53-ALTERED TUMORS AND POTENTIAL TARGET SPECTRUM IS NOT LIMITED BY THE P73 STATUS
Authors: F. Kuehnel, E. Guerlevik, T.C. Wirth, L. Zender, M.P. Manns, S. Kubicka
Journal: Journal of Hepatology (2008)