tbuckley/cabot-search huggingface dataset:
Hepatic Granulomas in Brucellosis
Authors: M. BRUGUERA
Journal: Annals of Internal Medicine (1980)

Letters1 April 1980Hepatic Granulomas in BrucellosisM. BRUGUERA, M.D., F. CERVANTES, M.D.M. BRUGUERA, M.D.Search for more papers by this author, F. CERVANTES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-4-571_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The statement of Young (1) in the September 1979 issue, that hepatic granulomas are present in infections due to Brucella abortus and absent in those caused by B. melitensis, is not accurate.Hepatic granulomas have been found in many patients with brucellosis living in Spain, where most cases are due toB. melitensis(2-4). In a recent review of 40 patients with serologically confirmed brucellosis in whom liver biopsy showed a variable degree of hepatic disease, granulomas were found in 28 (70%) (CERVANTESF, BRUGUERAM, CARBONELLJ, FORCEL, WEBBS. Liver disease in brucellosis: clinical...References1. YOUNG E. Brucella melitensis hepatitis: the absence of granulomas. Ann Intern Med. 1979;91:414-5. LinkGoogle Scholar2. PEDRO PONSBACARDIALVAREZ ARR. Hígado melitocócico. Med Clin (Barcelona). 1945;5:15-20. Google Scholar3. VIVANCOSBRUGUERACABRERDIAZSALAMERO JMBFP. Lesiones hepáticas en la brucelosis. Rev Clin Esp. 1973;131:119-24. MedlineGoogle Scholar4. SANTILLANACASTAÑEDAFRAGARUIZ TEIA. Brucelosis: consideraciones clínicas y terapéuticas: revisión de 50 casos. Rev Clin Esp. 1976;141:131-6. MedlineGoogle Scholar1. YOUNG E. Brucella melitensis hepatitis: the absence of granulomas. Ann Intern Med. 1979;91:414-5. LinkGoogle Scholar2. LEDRO MOLINALLAMAS CADEVALHERRERIASGARRIDO PERALTA DRJM. Granulomatosis hepática brucellosica. Rev Clin Esp. 1979;152:465-70. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: M. BRUGUERA, M.D.; F. CERVANTES, M.D.Affiliations: Hospital Clínico y Provincial Barcelona, Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBrucellar ArthritisLiver and Bile Duct InfectionsGranulomatose hépatiqueBrucellosisLiver and Bile Duct InfectionsGranulomatose hépatiqueChronic hepatosplenic abscesses in brucellosis. Clinico-therapeutic features and molecular diagnostic approachGastrointestinal BrucellosisHistopathological FeaturesBruzellose mit tödlichem EndotoxinschockPathology of Brucellosis: A Review of 88 BiopsiesGranulomatous Liver Disease: Clinical AspectsHistopathological featuresGastrointestinal brucellosisAcute and Chronic Hepatic Involvement of Brucellosis 1 April 1980Volume 92, Issue 4Page: 571-572KeywordsBiopsyBrucellaBrucellosisGranulomasLiverLiver diseases ePublished: 1 December 2008 Issue Published: 1 April 1980 PDF downloadLoading ...
Effect of enprostil, a synthetic prostaglandin E2 on 24 hour intragastric acidity, nocturnal acid and pepsin secretion.
Authors: M Deakin, J Ramage, A Paul, S P Gray, J Billings, J G Williams
Journal: Gut (1986)

We have studied the effect of a prostaglandin E2 analogue (enprostil), on intragastric acidity, gastric acid and pepsin outputs during a 24 hour period in nine patients with duodenal ulcer in remission. Enprostil 35 micrograms bd dose inhibited 24 hour intragastric acidity by 38% and a 70 micrograms nocturnal dose by 33%. Decrease in nocturnal pepsin secretion was both volume and concentration related.
H-2-linked genes influence the severity of herpes simplex virus infection of the peripheral nervous system.
Authors: A Simmons
Journal: The Journal of Experimental Medicine (1989)

Infection of the peripheral nervous system was studied after inoculation of HSV into the flank skin of H-2 congenic mice. The amount of virus recovered from the sensory ganglia varied significantly between the mouse strains tested. Differences became apparent 7 d after infection, at which time the severity of disease in H-2k mice was two to three orders of magnitude greater than that in H-2d animals. The association of the H-2k haplotype with impaired ability to clear HSV from the nervous system is the first clear demonstration that genes within the MHC can influence the severity of primary herpetic infection, in spite of numerous studies on genetic resistance to this disease.
Improved Computerized Quantitation of TI-201 Myocardial Scintigrams by Combining Two Views
Authors: JOSEP G. LLAURADO, JAMES D. HORGAN, VIRINDERJIT S. BAMRAH, CHARLES M. KRONENWETTER, PHILIP P. RUETZ
Journal: Clinical Nuclear Medicine (1982)

An improved computerized procedure involving minimal operator intervention has been developed for the automated quantitative evaluation of circumferential profiles of TI-201 myocardial perfusion scintigrams to diagnose coronary artery disease. The optimal criteria for evaluating the profiles of the left anterior oblique and anterior views have been empirically determined for both immediate and delayed scintigrams. Information from both views is combined to determine values for sensitivity and specificity. In this study, 29 patients underwent both TI-201 scintigraphy and contrast coronary angiography. The computerized quantitative procedure to interpret TI-201 scintigrams was tested against the results of coronary angiography. The values of 95% for sensitivity and 100% for specificity compare well with the results of other methods and are free of most of the variables associated with visual interpretation or operator intervention on the computer.
Frequency of Prenatal Care Visits and Perinatal Outcome-Reply
Authors: Robert S. McDuffie
Journal: JAMA (1996)

<h3>In Reply.</h3> —We thank Dr Zalar for his interest in our article. We appreciate his acknowledgment of the "good science" in our methodology and would like to take this opportunity to address his concerns. First, we do agree that we included some maternal outcomes that might not be affected by the number of prenatal care visits. We provided these for completeness. We believe that these outcomes occur among low-risk as well as high-risk women. We differ with Zalar's interpretation of our rates of adverse outcomes. First, we did not believe that the use of the Expert Panel on the Context of Prenatal Care schedule would decrease perinatal morbidity and mortality. Second, while all women were low risk at enrollment, some developed complications of pregnancy that resulted in preterm births and low-birth-weight neonates. Women with complications were not excluded from analysis. These complications included multiple gestation and placenta previa. Although Zalar objects to
WHOLE MILK VERSUS LABORATORY MILK.
Authors: A. McALLISTER
Journal: JAMA (1906)

Whatever opinion is entertained as to the intrinsic value and practical utility of cows' milk modified by the percentage method, as practiced in special laboratories, there is unanimity in pronouncing the plan the best yet advanced for securing constancy in the constituents of a substitute infant food. It admits of accuracy to a small fraction as no other known method does. It renders possible, from day to day, feedings practically invariable as to their proteids, fat and sugar. In short, the laboratory product is an ideal substitute for mother's milk, theoretically. But if the accumulated experience in infant feeding has established one thing beyond another it is that we are not up against a theory but against a condition—a condition as stubborn as any met in the practice of medicine. This condition is unnatural, morbid and confusingly variable. Infants are born anatomically and physiologically built for the warm mother breast
THE CAUSE OF THE HEART BEAT.
Authors: W. H. HOWELL
Journal: JAMA (1906)

<h3>HISTORICAL REVIEW.</h3><h3>The Seventeenth Century: Harvey and Willis.</h3> —It is known to all students of the history of medicine that what may be designated in general as the modern point of view regarding the cause of the heart beat dates from the work of William Harvey. Before his time physicians thought along the lines laid down by the ancient masters, in that they conceived the expansion of the heart in diastole to be an active, or rather the active phenomenon of the heart beat. This expansion was attributed to the innate or implanted heat, to the vital spirits, to the pulsatile force, etc. That the diastole of the heart is an active rather than a passive expansion has been held in a sense by many prominent physiologists, even in the nineteenth century. Magendie, for example, states that at first he entertained this belief. Nevertheless it remains true that Harvey's experiments
The Effect of Aspirin on the Antiproteinuric Properties of Enalapril in Microalbuminuric Type 2 Diabetic Patients
Authors: Eduardo G. Camargo, Letícia S. Weinert, Joel Lavinsky, Jorge L. Gross, Sandra P. Silveiro
Journal: Diabetes Care (2007)

The concomitant use of angiotensin-converting enzyme inhibitors (ACEIs) and aspirin is recommended for any diabetic patient with microalbuminuria or macroalbuminuria because these drugs result in renal and cardiovascular benefits (1,2). However, a putative pharmacological interaction between these drugs is plausible, through their opposite effects on vasodilator prostaglandins (3). Therefore, the aim of this study was to analyze the possible interference of intermediate-dose aspirin (300 mg/day) on urinary albumin excretion (UAE) reduction properties of enalapril in microalbuminuric type 2 diabetic patients.

In this randomized, crossover, double-blind, placebo-controlled …
In vitro adenylate cyclase-stimulating activity predicts the occurrence of humoral hypercalcemia of malignancy in nude mice.
Authors: E C Weir, K L Insogna, D G Brownstein, N H Bander, A E Broadus
Journal: Journal of Clinical Investigation (1988)

A number of factors have been proposed as potential mediators of the syndrome of humoral hypercalcemia of malignancy (HHM), but to date no firm cause-and-effect relationship has been established. We attempted to establish such a relationship by determining whether the presence or absence of adenylate cyclase-stimulating activity (ACSA) in the media of cultured tumor cells predicted the occurrence of the syndrome of HHM when these cell lines were grown in nude mice in vivo. Conditioned media from 35 human renal carcinoma cell lines were surveyed for ACSA in the PTH-sensitive rat osteosarcoma 17/2.8 cell assay. 12 lines were positive (mean, 13.7-fold stimulation, range, 3.0 to 44.0), and 23 lines were negative (mean, 1.2-fold stimulation, range, 0.9 to 1.5). We were successful in establishing five of the positive and six of the negative lines in three to five nude mice per line. Mice implanted with the positive lines uniformly became hypercalcemic (mean serum calcium, 15.8 mg/dl), whereas mice implanted with the negative lines uniformly remained normocalcemic (mean serum calcium, 9.5 mg/dl), in spite of comparable mean tumor size. Acid-urea tumor extracts from each of four hypercalcemic animals contained potent in vitro ACSA (mean, 15.9-fold stimulation), while 5/5 extracts from normocalcemic animals did not (mean, 1.4-fold stimulation). Our study demonstrates that in this model system in vitro ACSA is a reliable predictive marker for HHM in vivo. Whether the protein responsible for this activity is also the mediator of the bone resorption seen in HHM remains to be demonstrated.
Critical Role of the NAD(P)H Oxidase Subunit p47 <sup> <i>phox</i> </sup> for Left Ventricular Remodeling/Dysfunction and Survival After Myocardial Infarction
Authors: Carola Doerries, Karsten Grote, Denise Hilfiker-Kleiner, Maren Luchtefeld, Arnd Schaefer, Steven M. Holland, Sajoscha Sorrentino, Costantina Manes, Bernhard Schieffer, Helmut Drexler, Ulf Landmesser
Journal: Circulation Research (2007)

Accumulating evidence suggests a critical role of increased reactive oxygen species production for left ventricular (LV) remodeling and dysfunction after myocardial infarction (MI). An increased myocardial activity of the NAD(P)H oxidase, a major oxidant enzyme system, has been observed in human heart failure; however, the role of the NAD(P)H oxidase for LV remodeling and dysfunction after MI remains to be determined. MI was induced in wild-type (WT) mice (n=46) and mice lacking the cytosolic NAD(P)H oxidase component p47 phox (p47 phox −/− mice) (n=32). Infarct size was similar among the groups. NAD(P)H oxidase activity was markedly increased in remote LV myocardium of WT mice after MI as compared with sham-operated mice (83±8 versus 16.7±3.5 nmol of O 2 − · μg −1 ·min −1 ; P &lt;0.01) but not in p47 phox −/− mice after MI (13.5±3.6 versus 15.5±3.5 nmol of O 2 − · μg −1 ·min −1 ), as assessed by electron-spin resonance spectroscopy using the spin probe CP-H. Furthermore, increased myocardial xanthine oxidase activity was observed in WT, but not in p47 phox −/− mice after MI, suggesting NAD(P)H oxidase–dependent xanthine oxidase activation. Myocardial reactive oxygen species production was increased in WT mice, but not in p47 phox −/− mice, after MI. LV cavity dilatation and dysfunction 4 weeks after MI were markedly attenuated in p47 phox −/− mice as compared with WT mice, as assessed by echocardiography (LV end-diastolic diameter: 4.5±0.2 versus 6.3±0.3 mm, P &lt;0.01; LV ejection fraction, 35.8±2.5 versus 22.6±4.4%, P &lt;0.05). Furthermore, cardiomyocyte hypertrophy, apoptosis, and interstitial fibrosis were substantially reduced in p47 phox −/− mice as compared with WT mice. Importantly, the survival rate was markedly higher in p47 phox −/− mice as compared with WT mice after MI (72% versus 48%; P &lt;0.05). These results suggest a pivotal role of NAD(P)H oxidase activation and its subunit p47 phox for LV remodeling/dysfunction and survival after MI. The NAD(P)H oxidase system represents therefore a potential novel therapeutic target to prevent cardiac failure after MI.
Deal with problem colleagues.
Authors: D Roy
Journal: BMJ (1987)

Relationships between medical practitioners, particularly in hospital practice, have always been complex, and attempts by colleagues or health districts to intervene when problems arise often lead to much bitterness and ill feeling. I do not intend to cover occasions when the law is concerned and the matter is dealt with directly by the disciplinary procedures of the General Medical Council, but rather to concentrate on the difficulties encountered by doctors who are mentally ill, including those suffering from alcoholism and drug dependence, and particularly when that illness directly affects the service that they are able to give to their patients. In addition, I shall discuss briefly clashes between colleagues, with particular emphasis on the blurring of issues between difficulties in professional relationships and questions of competence. These cases are much more complex than those concerning sick doctors.
Do Weed-killers Poison Food?
Authors: J. H. Whittles
Journal: BMJ (1950)

<h3>Abstract</h3> Because terminology varies widely from study-to-study, and even more so from discipline-to-discipline, the neuroimaging literature is becoming increasingly complex to navigate. For examples: (1) terminology changes over time (e.g., alcoholism to alcohol use disorders), (2) a single term can have many—or even amorphous—definitions (e.g., MVPA as multi-voxel or multivariate pattern analysis, which itself spans numerous different techniques) and (3) multiple terms describe the same concept (e.g., in vision studies “striate cortex,” “calcarine sulcus,” “V1,” “primary visual cortex,” and “Brodmann area 17,” all describe, essentially, the same brain region in functional neuroimaging). Such a diversity of terminologies makes interpretations, reviews, and meta-analyses of the literature difficult to perform and consume. As the volume of scientific questions across neuroimaging has grown—and with this growth, the evolution of terminology across neuroimaging—it is important to clarify: What are the primary domains of neuroimaging and what are their most commonly reported brain regions?
Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope
Authors: Astrid K N Iversen, Guillaume Stewart-Jones, Gerald H Learn, Natasha Christie, Christina Sylvester-Hviid, Andrew E Armitage, Rupert Kaul, Tara Beattie, Jean K Lee, Yanping Li, Pojchong Chotiyarnwong, Tao Dong, Xiaoning Xu, Mark A Luscher, Kelly MacDonald, Henrik Ullum, Bente Klarlund-Pedersen, Peter Skinhøj, Lars Fugger, Søren Buus, James I Mullins, E Yvonne Jones, P Anton van der Merwe, Andrew J McMichael
Journal: Nature Immunology (2006)
Autoimmune Vitiligo
Authors: Kenneth C. Hertz, Laura A. Gazze, Charles H. Kirkpatrick, Stephen I. Katz
Journal: New England Journal of Medicine (1977)

Vitiligo, a disorder characterized by the destruction of melanocytes, is often associated with diseases in which there are increased frequencies of autoantibodies. For this reason we investigated two patients with vitiligo, alopecia universalis, mucocutaneous candidiasis, and multiple endocrine insufficiencies for antibodies to melanin-producing cells. Using direct immunofluorescence of normal and vitiliginous skin from both patients and indirect immunofluorescence with both patients' serum, we could not detect these antibodies. However, an immunofluorescent complement-fixation test demonstrated a circulating antibody that bound to melanocytes in human skin, nevus cells and melanoma cells. Specificity of cellular fluorescence for nevus and melanoma cells was shown on serial sections stained with hematoxylin and eosin and was inferred for melanocytes from their distribution in human skin and their presence when the normal but not vitiliginous skin of both patients was used as substrate. This antibody was characterized as an IgG that activated complement via the classical pathway.
Hebraic Attitudes Toward Sex
Authors: William B. Helme
Journal: JAMA (1971)

<h3>To the Editor.—</h3> In my opinion the Marmor paper had no place in a presumably scientific journal. It appears to represent the unsupported, unscientific musings of one of the "far out" psychiatrists and should have had a much readier market in<i>Playboy</i>. Moral values really do not change, despite the wishes of Marmor and other hedonists to the contrary. I would hope thatThe Journalwould not further such philosophy by featuring this type of communication.
Letter Regarding the Article, “A Detailed Analysis of Bone Marrow From Patients With Ischemic Heart Disease and Left Ventricular Dysfunction: BM CD34, CD11b, and Clonogenic Capacity as Biomarkers for Clinical Outcomes”
Authors: Hendrik Gremmels, Diana A. Papazova, Joost O. Fledderus, Marianne C. Verhaar
Journal: Circulation Research (2014)
James M. Venable: First Patient to Receive Ether Anesthesia
Authors: Herzl Katz
Journal: JAMA (1976)

To the Editor.—  I am pleased that Gilbert Abbott was acknowledged inThe Journal(235:706, 1976). Perhaps it was shortsighted, but not intentional, to have slighted my colleagues from below the Mason-Dixon Line by failing to mention another great name inmedical history, James M. Venable, the first patient to receive a surgical ether anesthetic on March 30, 1842, administered by Crawford W. Long, MD, of Jefferson, Ga. According to Keys, 1 Mr Venable was a personal friend of Dr Long's, and it was only after some persuasion that Venable agreed to the anesthetic, for removal of a small tumor of the neck. Dr Long did not publish an account of the procedure until December 1849, in the Southern Medical and Surgical Journal.  Henceforth, we shall indeed celebrate James M. Venable Day on March 30. A frolic is a frolic, and two a year is better than one.
TRANSTHORACIC ECHOCARDIOGRAPHY PROVIDES IMPORTANT LONG–TERM PROGNOSTIC INFORMATION IN PATIENTS UNDERGOING ENDOVASCULAR ABDOMINAL AORTIC REPAIR
Authors: Jamie Michael O'Driscoll, Angela Gravina, Sara Di Fino, Matt Thompson, Alan Karthikesalingam, Kausik Ray, Rajan Sharma
Journal: Journal of the American College of Cardiology (2013)
Syphilis
Authors: Terrence J. Lee
Journal: JAMA (1979)

SINCE the development of the Wassermann complement-fixation test in 1906, laboratory tests have been invaluable aids in the diagnosis of syphilis. The use of these tests continues on a large scale, but their utility and interpretation are not always clear to the physician, who is the one who must make the critical decisions concerning treatment. The two basic types of serological tests currently available are nontreponemal and treponemal. The standard nontreponemal test used in the United States is the VDRL slide test. Other related tests include the rapid plasma reagin and unheated serum reagin tests. Since the antibody measured (reagin) can also be present transiently after immunizations or various febrile illnesses and chronically in conditions such as collagen vascular disease, leprosy, and drug addiction, VDRL test reactivity is not specific for syphilis. On the other hand, the VDRL test is easily quantitated, and serial titers are helpful in following the
Disruption of E-Cadherin-Mediated Adhesion Induces a Functionally Distinct Pathway of Dendritic Cell Maturation
Authors: Aimin Jiang, Ona Bloom, Satoru Ono, Weiguo Cui, Juli Unternaehrer, Shan Jiang, J. Andrew Whitney, John Connolly, Jacques Banchereau, Ira Mellman
Journal: Immunity (2007)
Neonatal classical galactosaemia presenting as citrin deficiency
Authors: Patrick J. McKiernan, Ulrich Baumann
Journal: Journal of Hepatology (2008)

We read with interest the recent study by Feillet et al. [[1]Feillet F. Merten M. Battaglia-Hsu S.F. Rabier D. Kobayashi K. Straczek J. et al.Evidence of cataplerosis in a patient with neonatal classical galactosemia presenting as citrin deficiency.J Hepatol. 2008; 48: 517-522Abstract Full Text Full Text PDF PubMed Scopus (5) Google Scholar]. This is an elegant paper which eloquently analyses and explains what turned out to be a secondary metabolic abnormality. We agree that neonatal citrin deficiency needed to be considered as a differential diagnosis, albeit a rare one. Clinical presentation of citrin deficiency is heterogeneous and non specific and galactosaemia is a well recognised biochemical feature. Although citrullinaemia is common it is not specific, may be absent and the diagnosis of citrin deficiency today largely depends on mutation analysis. In neonatal liver failure, in particular, it is often difficult to distinguish between what are primary metabolic abnormalities causing liver dysfunction and secondary abnormalities as a result of liver dysfunction. The situation can become particularly complicated when there has been a delay in diagnosis or partial treatment as in this case. In the setting of such a complex multi-systemic disease, it is important to have some simple guiding principles. Galactosaemia is one of the commonest causes of neonatal liver failure. A galactose free diet should be given to all children with neonatal liver failure until galactosaemia has been specifically excluded by enzyme analysis. A galactose challenge is neither appropriate nor necessary as a diagnostic test for galactosaemia and is not without risk. An approach to the diagnosis or exclusion of possible galactosaemia when the situation is complicated is summarised in a recent review [[2]McKiernan P.J. The acutely ill baby.in: Kelly D.A. Diseases of the liver and biliary system in children. 2nd ed. Blackwell Publishing Ltd., Oxford2004: 74-91Google Scholar].