tbuckley/cabot-search huggingface dataset:
"KANGRI CANCER": A PHYSIOLOGICAL ASPECT
Authors: H. D. McCulloch
Journal: BMJ (1910)

may be able to practise it yourself, even if you are only one of the laity.But, any way, we can put you in the way to obtain spiritual healing."This is no fantastic interpretation of the aims of this guild, and I repeat that such societies can only retard that most desirable closer union of religion and medicine in a combined attempt to help the mental and physical health of mankind.-Iam, etc.,
Intensive care is not expensive compared with other treatments
Authors: M. Stockwell
Journal: BMJ (1999)

EDITOR—The article by Bennett and Bion in the ABC of Intensive Care contains one statement that should not go unchallenged—that “intensive care is expensive.”1 This is true only at the most simple level unless comparisons are made with other treatments.

The internal evidence of Bennett and Bion's review is that an absolute risk reduction of 50% is possible, at least in polio, …
Cholestyramine in treatment of postvagotomy diarrhoea--double-blind controlled trial.
Authors: J G Allan, R I Russell
Journal: BMJ (1977)

A double-blind controlled trial was performed to assess the effectiveness of cholestyramine in treating severe continuous postvagotomy diarrhoea. Each patient and a clinician assessed the results, and those treated with cholestyramine showed a considerable improvement over those given placebo. There were no significant side effects or changes in laboratory values in the cholestyramine group. Although the numbers were too small for statistical analysis, these results suggest that cholestyramine may be of value in the management of some patients with severe continuous postvagotomy diarrhoea who are unresponsive to other forms of treatment.
A Positional Maneuver to Augment Conventional Cholescintigraphy in the Evaluation of Acute Acalculous Cholecystitis
Authors: Stephan Anderson, Nirav P. Shah, Donald Zajick, Mary Cross, M Elizabeth Oates
Journal: Clinical Nuclear Medicine (2006)

Cholescintigraphy is commonly used as an accurate functional complement to anatomic imaging for diagnosing acute calculous cholecystitis. Although less common, acute acalculous cholecystitis (AAC) can also cause right upper quadrant pain, especially in hospitalized and critically ill patients. Moreover, traditional cholescintigraphy, even with morphine augmentation, is less sensitive and specific in diagnosing AAC. We present a case of suspected AAC in a hospitalized ill patient in whom simple physiological augmentation using patient positioning during cholescintigraphy avoided a false-positive result of AAC. The routine use of such physiological maneuvers may increase the accuracy of traditional cholescintigraphy in patients with suspected AAC.
SEX DIFFERENCES IN PRESENTATION WITHOUT CHEST PAIN FOR CONFIRMED MYOCARDIAL INFARCTION ARE ATTENUATED WITH ADVANCING AGE IN THE NATIONAL REGISTRY OF MYOCARDIAL INFARCTION (NRMI)
Authors: John G. Canto, William J. Rogers, Robert J. Goldberg, Eric D. Peterson, Nanette K. Wenger, Viola Vaccarino, Catarina I. Kiefe, Paul Frederick, George Sopko, Z.J. Zheng, None For the NRMI Investigators
Journal: Journal of the American College of Cardiology (2010)
Aldosterone Excretion: PHYSIOLOGICAL VARIATIONS IN MAN MEASURED BY RADIOIMMUNOASSAY OR DOUBLE-ISOTOPE DILUTION
Authors: J. E. Sealey, F. R. Bühler, J. H. Laragh, E. L. Manning, H. R. Brunner
Journal: Circulation Research (1972)

A reliable, simple radioimmunoassay for measurement of the urinary excretion rate of the acid-labile conjugate of aldosterone is described, in which aldosterone, reconstituted by acid hydrolysis of a urinary metabolite, is quantified. The results were compared with those obtained by double-isotope dilution. Using both methods, aldosterone excretion rates were characterized in normal subjects over a wide range of dietary sodium intakes. Identity of results from the two methods was demonstrated. Aldosterone excretion ranged from 18 to 85 µg/day at sodium excretion rates of less than 25 mEq/day, from 5 to 26 µg/day at sodium excretion rates between 75 and 125 mEq/day, and from 1.5 to 12.5 µg/day at excretion rates above 200 mEq/day. However, a more precise index was derived with limits inscribed by the whole curve used as a nomogram. During sodium depletion of normal subjects, aldosterone excretion reacted slowly and inadequately until a critical level of sodium or volume depletion was reached. During maintained sodium loading for up to 11 days, initial sodium retention was followed by natriuresis and then by slight sodium retention. Mean urinary aldosterone during these three periods was 23.4, 3.6, and 4.5 µg/day, respectively. Urinary sodium excretion exhibited a more consistent relationship to aldosterone activity than did either sodium intake or cumulative sodium balance, even when constant dietary regimens were used. These data suggest a dynamic role for aldosterone in governing renal sodium excretion, even at very high levels of sodium excretion.
One in 10 British men has paid for sex, survey finds
Authors: J. Wise
Journal: BMJ (2014)

A 10th of men in Britain report having paid for sex, and this group has an increased risk of acquiring a sexually transmitted infection, a large survey has found.

The National Survey of Sexual Attitudes and Lifestyles (Natsal-3)1 asked 6293 men aged 17-74 to answer questions in a computer assisted self interview. A total of 6108 men (97%) answered the question on paying for sex, and of these 11% reported …
Role of sodium in thyroid hormone uptake by rat skeletal muscle.
Authors: M Centanni, J Robbins
Journal: Journal of Clinical Investigation (1987)

Whether Na+ movement through the plasma membrane plays a role in thyroid hormone uptake was investigated in intact rat soleus muscles. After preincubation for 120 min at 37 degrees C in modified Krebs-Ringer bicarbonate containing 140 or 5 mM Na+ plus choline or lithium to maintain osmolarity, muscles were incubated with 50 pM [125I]triiodo-L-thyronine (T3) or [125I]L-thyroxine (T4) for 60 min. T3 uptake was decreased when extracellular Na+ was replaced by either choline or lithium, the amount of decrease corresponding to the specific (or saturable) uptake component. Monensin, an ionophore that stimulates Na+ entry, increased T3 uptake at 140 mM Na+ but not at 5 mM Na+. Amiloride, a Na+/H+ exchange inhibitor, had no effect on T3 uptake under basal conditions or when Na+ was replaced by choline, but reversed the action of lithium. Ouabain, an inhibitor of Na+/K+ ATPase, reduced specific T3 uptake. T4 uptake was unaffected by low extracellular Na+. These results are consistent with a major role of Na+ movement in T3 uptake by skeletal muscle, but not in T4 uptake, and suggest an involvement of membrane pumps in this process.
Duverney Fracture: Distinguishing Scintigraphic Features
Authors: Basem Yacoub, William S. Collier
Journal: Clinical Nuclear Medicine (2007)

Duverney fractures are isolated fractures of the iliac wing due to direct lateral compression. The fracture involves the anterior and superior iliac crest. The location and the scintigraphic appearance are distinctive with increased uptake extending from the fracture margin to the superior and lateral margins of the iliac crest. For this 58-year-old female patient, 5 years status postmastectomy for breast cancer, bone scintigraphy was undertaken to exclude skeletal metastases. Despite a history of recent pelvic trauma and CT evidence of a healing fracture, biopsy was performed. Biopsy yielded only evidence of a healing fracture.
High-dose oral multivitamins and minerals after MI did not reduce CV events
Authors: Hanna E. Bloomfield
Journal: Annals of Internal Medicine (2014)

ACP Journal Club20 May 2014High-dose oral multivitamins and minerals after MI did not reduce CV eventsHanna E. Bloomfield, MD, MPHHanna E. Bloomfield, MD, MPHVA Medical Center and University of Minnesota, Minneapolis, Minnesota, USA (H.E.B.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-160-10-201405200-02004 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationLamas GA, Boineau R, Goertz C, et al. Oral high-dose multivitamins and minerals after myocardial infarction: a randomized trial. Ann Intern Med. 2013;159:797-805. https://pubmed.ncbi.nlm.nih.gov/24490264Clinical Impact RatingsGIM/FP/GP: Cardiology: References1 Sesso HD, Christen WG, Bubes V, et al. Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA. 2012;308:1751-60. [PMID: 23117775] Google Scholar2 Gaziano JM, Sesso HD, Christen WG, et al. Multivitamins in the prevention of cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA. 2012;308:1871-80. [PMID: 23162860] Google Scholar Author, Article, and Disclosure InformationAffiliations: VA Medical Center and University of Minnesota, Minneapolis, Minnesota, USA (H.E.B.)This article was published at Annals.org on 6 May 2014. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 May 2014Volume 160, Issue 10Page: JC4KeywordsAnginaCoronary revascularizationHeartHospitalizationsMyocardial infarctionSaline solutionsStatinsStroke ePublished: 20 May 2014 Issue Published: 20 May 2014 CopyrightCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Large Bowel Adenomas
Authors: C. M. Fenoglio-Preiser, M. V. Sivak, J. J. DeCosse
Journal: CA A Cancer Journal for Clinicians (1989)

The last 20 years have witnessed dramatic technological advances in the diagnosis and treatment of colorectal polyps. These developments, in addition to an increased understanding of large bowel carcinogenesis, have shifted the risk/benefit balance toward a more aggressive approach to colorectal polyps. Mounting evidence for the adenoma-carcinoma sequence supports the position that all colorectal polyps should be removed, recovered, and evaluated. Moreover, in most cases polypectomy can be achieved endoscopically. To justify surgery today, adenomas must be too large to be removed endoscopically, located in the distal rectum, or malignant with submucosal invasion or questionable margins.
Comparison of short-course multidrug treatment with standard therapy for visceral leishmaniasis in India: an open-label, non-inferiority, randomised controlled trial
Authors: Shyam Sundar, Prabhat Kumar Sinha, Madhukar Rai, Deepak Kumar Verma, Kumar Nawin, Shanawwaj Alam, Jaya Chakravarty, Michel Vaillant, Neena Verma, Krishna Pandey, Poonam Kumari, Chandra Shekhar Lal, Rakesh Arora, Bhawna Sharma, Sally Ellis, Nathalie Strub-Wourgaft, Manica Balasegaram, Piero Olliaro, Pradeep Das, Farrokh Modabber
Journal: The Lancet (2011)
P46 INHIBITION OF AUTOPHAGIC FLUX BY SALINOMYCIN RESULTS IN ANTI-CANCER EFFECT IN HEPATOCELLULAR CARCINOMA CELLS
Authors: J. Klose, M. Stankov, M. Kleine, W. Ramackers, M. Jäger, J. Klempnauer, M. Winkler, H. Bektas, G. Behrens, F. Vondran
Journal: Journal of Hepatology (2014)
Abdominal Angina— Diagnosis and Surgical Treatment
Authors: George C. Morris
Journal: JAMA (1961)

Although the syndrome of abdominal angina has been recognized occasionally for many years, it is seldom diagnosed before death or operation for mesenteric thrombosis. The condition usually occurs in patients of the arteriosclerotic age group. Outstanding symptoms include postprandial pain, weight loss, and constipation. Gastrointestinal studies may be negative or may show evidence of impaired intestinal motility, excessive fat in the feces, and occult blood. Aortography with exposure of the visceral vessels in the lateral projection provides definitive diagnosis and affords clear visualization of the proximal and segmental character of the occlusive process. Revascularization of the celiac and superior mesenteric arteries by arterial reconstructive procedures is important not only to alleviate symptoms but to prevent mesenteric thrombosis and death.
Cocaine Metabolite Detection in Homicide Victims
Authors: Randy Hanzlick
Journal: JAMA (1991)

We analyzed the blood of homicide victims for the presence of cocaine's major metabolite, benzoylecgonine. During 1989 in Fulton County, Georgia, 81% of 275 homicide victims were tested for benzoylecgonine; 40% tested positive. The proportions of blacks and victims of firearm injuries who tested positive for benzoylecgonine were significantly larger than the respective proportions for whites and victims of injuries not involving firearms. The data show overall proportions of benzoylecgonine positivity much larger than those previously reported in the literature. The relationships between homicide, race, firearms, and cocaine use deserve further study. (<i>JAMA</i>. 1991;265:760-761)
THE ADVANTAGES OF NITROUS OXIDE AND AIR ANALGESIA IN THE MIDWIFERY OF GENERAL AND HOSPITAL PRACTICE
Authors: J. Elam
Journal: BMJ (1934)

MIDWIFERYMTEBAJrTSRL probably had some connexion in this.case on account of the small dose of the drug that was taken.5. The pathological features are quite classical and are similar to those of other reported cases; they are of interest from the close resemblance to the condition met with in cases of trinitrotoluol poisoning.6.The advisability of the abandonment, or at least better control, of the administration of cinchophen should be considered.I should like to thank Dr. Buchanan for notes of the case prior to admission, Dr. Mackenzie for permission to record the case,
Phagocytosis and intracellular killing of MD-2 opsonized Gram-negative bacteria depend on TLR4 signaling
Authors: Vishal Jain, Annett Halle, Kristen A. Halmen, Egil Lien, Marie Charrel-Dennis, Sanjay Ram, Douglas T. Golenbock, Alberto Visintin
Journal: Blood (2008)
Prioritizing Pregnant Women for Long-Lasting Insecticide Treated Nets through Antenatal Care Clinics
Authors: Jenny Hill, Jenna Hoyt, Anna Maria van Eijk, Feiko O. ter Kuile, Jayne Webster, Richard W. Steketee
Journal: PLoS Medicine (2014)

Jenny Hill and colleagues discuss the importance of antenatal care services in providing pregnant women with a long-lasting insecticide treated net for the prevention of malaria in both the mother and infant. Please see later in the article for the Editors' Summary
Leukoencephalopathy and Elevated Levels of Myelin Basic Protein in the Cerebrospinal Fluid of Patients with Acute Lymphoblastic Leukemia
Authors: Diamon Gangji, Gregory H. Reaman, Stephen R. Cohen, W. Archie Bleyer, David G. Poplack
Journal: New England Journal of Medicine (1980)

AS the survival of patients with acute lymphoblastic leukemia has improved, increased attention has focused on the potential toxicity and adverse long-term sequelae of antileukemic therapy. In particular, there is considerable interest in the toxic effects on the central nervous system that may result from therapy to treat or prevent meningeal leukemia. A wide range of neurotoxicities have been described, the most serious of which is the syndrome of necrotizing leukoencephalopathy associated with cranial irradiation and the administration of methotrexate.1 2 3 4 5 Clinically, patients with this delayed form of neurotoxicity present with symptoms such as poor performance in school, forgetfulness, and confusion. . . .
RESORCIN ANAL DERMATITIS DUE TO RESORCIN IN ANUSOL SUPPOSITORIES
Authors: James H. Mitchell
Journal: JAMA (1933)

Resorcin sensitization is encountered from time to time in dermatologic practice. What the percentage of sensitized individuals may be is unknown at present. Urbach 1 says that only one person in several thousand will be found sensitized, and Nathan and Stern 2 state that cases of resorcin sensitization are rare.  Resorcin (metadihydroxybenzene) is an ingredient of many hair lotions sold in the shops and used by hair dressers and barbers. Examination of the prescription files of a pharmacy doing a large prescription business discloses that many prescriptions for resorcin are filled daily and that resorcin is prescribed about four times more frequently than is monoresorcinol acetate (introduced as Euresol).  An informal inquiry of some of the druggists doing a large volume of business in the Chicago loop district indicates that the sale of Anusol suppositories is heavy. No one interviewed, however, had had any complaint of irritation set up by
A book that changed me: Birdsong
Authors: P. Slade
Journal: BMJ (1999)

Sebastian Faulks

Vintage, £6.99, pp 416

ISBN 0 09 938791 3

Isuspect there are many books that have moulded me, shaped my personality, even determined my mood from one day to the next, but, for its sheer impact and seismic change on my outlook on life, I must choose Birdsong.

This is one of the most startlingly evocative books of this, or any, generation. Starting as a rather gentle romantic tale set in France in the early years of this century, the story takes a dramatic lurch into the horrors of the trenches of the first world war. Although it is a familiar story, Faulks produces a vivid and traumatising description of the sights and sounds of life and death in (and under) the trenches. The pure fury and intensity of the imagery created page after page is, by turns, compelling, profoundly shocking, and, ultimately, desperately uncomfortable to read.

It slowly dawned on me that, among my patients, I must actually have known some people for whom these imagined experiences and atrocities had been only too real—for weeks, months, and even years on end. My ritualistic and somewhat perfunctory history taking had, I now guessed, been insultingly superficial for some of these diehards, now undoubtedly frustrated by their increasing antiquity and physical infirmity. Despite the horrors they had faced in the past, and the increasing uncertainties they faced for the future, they had remained stoic to the last, as if any sign of weakness was a signal to the Almighty that those battles fought 70 years before had been in vain. I could not help wondering, however, if these increasingly frequent battles with ill health would finally sap their spirit.

I realised that Faulks' work had allowed me to appreciate that true greatness might often be close at hand. It also brought home to me that, even in our fin de siecle sophistication, inhumanity and depravity will never be far from us—they are the flip side of the human coin. Without wanting to sound unduly pious, I do commend this book to anyone wishing to spend a few humbling hours trying to understand the sacrifices that some among us made.

We welcome contributions for “A book that changed me” of up to 400 words.
Aircraft noise and cardiovascular disease near Heathrow airport in London: small area study
Authors: A. L. Hansell, M. Blangiardo, L. Fortunato, S. Floud, K. de Hoogh, D. Fecht, R. E. Ghosh, H. E. Laszlo, C. Pearson, L. Beale, S. Beevers, J. Gulliver, N. Best, S. Richardson, P. Elliott
Journal: BMJ (2013)

<b>Objective</b> To investigate the association of aircraft noise with risk of stroke, coronary heart disease, and cardiovascular disease in the general population. <b>Design</b> Small area study. <b>Setting</b> 12 London boroughs and nine districts west of London exposed to aircraft noise related to Heathrow airport in London. <b>Population</b> About 3.6 million residents living near Heathrow airport. Risks for hospital admissions were assessed in 12 110 census output areas (average population about 300 inhabitants) and risks for mortality in 2378 super output areas (about 1500 inhabitants). <b>Main outcome measures</b> Risk of hospital admissions for, and mortality from, stroke, coronary heart disease, and cardiovascular disease, 2001-05. <b>Results</b> Hospital admissions showed statistically significant linear trends (P&lt;0.001 to P&lt;0.05) of increasing risk with higher levels of both daytime (average A weighted equivalent noise 7 am to 11 pm, L<sub>Aeq,16h</sub>) and night time (11 pm to 7 am, L<sub>night</sub>) aircraft noise. When areas experiencing the highest levels of daytime aircraft noise were compared with those experiencing the lowest levels (&gt;63 dB <i>v</i> ≤51 dB), the relative risk of hospital admissions for stroke was 1.24 (95% confidence interval 1.08 to 1.43), for coronary heart disease was 1.21 (1.12 to 1.31), and for cardiovascular disease was 1.14 (1.08 to 1.20) adjusted for age, sex, ethnicity, deprivation, and a smoking proxy (lung cancer mortality) using a Poisson regression model including a random effect term to account for residual heterogeneity. Corresponding relative risks for mortality were of similar magnitude, although with wider confidence limits. Admissions for coronary heart disease and cardiovascular disease were particularly affected by adjustment for South Asian ethnicity, which needs to be considered in interpretation. All results were robust to adjustment for particulate matter (PM<sub>10</sub>) air pollution, and road traffic noise, possible for London boroughs (population about 2.6 million). We could not distinguish between the effects of daytime or night time noise as these measures were highly correlated. <b>Conclusion</b> High levels of aircraft noise were associated with increased risks of stroke, coronary heart disease, and cardiovascular disease for both hospital admissions and mortality in areas near Heathrow airport in London. As well as the possibility of causal associations, alternative explanations such as residual confounding and potential for ecological bias should be considered.
Choledochal cyst type IA with drainage through the ventral duct in pancreas divisum
Authors: M. Bechtler, A. Eickhoff, S. Willis, J. Riemann
Journal: Endoscopy (2009)

Choledochal cyst is a rare disease in Western adults. It is frequently associated (about 70 %) with an abnormal pancreaticobiliary junction, but a choledochal cyst occurring with pancreas divisum is a very rare condition. This is, to our knowledge, the first published case of a choledochal cyst draining into the ventral duct system in cases of pancreas divisum.
The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development
Authors: Masaya Baba, Jonathan R. Keller, Hong-Wei Sun, Wolfgang Resch, Stefan Kuchen, Hyung Chan Suh, Hisashi Hasumi, Yukiko Hasumi, Kyong-Rim Kieffer-Kwon, Carme Gallego Gonzalez, Robert M. Hughes, Mara E. Klein, Hyoungbin F. Oh, Paul Bible, Eileen Southon, Lino Tessarollo, Laura S. Schmidt, W. Marston Linehan, Rafael Casellas
Journal: Blood (2012)
Rce1 deficiency accelerates the development of K-RAS–induced myeloproliferative disease
Authors: Annika M. Wahlstrom, Briony A. Cutts, Christin Karlsson, Karin M. E. Andersson, Meng Liu, Anna-Karin M. Sjogren, Birgitta Swolin, Stephen G. Young, Martin O. Bergo
Journal: Blood (2006)
Observations on 205 confirmed cases of acute pancreatitis, recurring pancreatitis, and chronic pancreatitis.
Authors: H Sarles, J C Sarles, R Camatte, R Muratore, M Gaini, C Guien, J Pastor, F Le Roy
Journal: Gut (1965)

EDITORIAL SYNOPSIS Two hundred and five confirmed cases of pancreatitis have been classified.Primary calcifying pancreatitis is associated with alcoholism.Pancreatic changes are patchy and related to plugging of minute ducts.Cysts are frequent.Obstruction to the main pancreatic duct may also result in chronic pancreatitis.Acute pancreatitis and acute recurrent pancreatitis are often associated with gall stones.Acute pancreatitis rarely progresses towards the chronic form.