tbuckley/cabot-search huggingface dataset:
The Computerized Dad
Authors: G. G. Liddle
Journal: JAMA (1973)

<h3>To the Editor.—</h3> The Journal'scontinuing presentations on genetic counseling and engineering, vasectomies, intrauterine contraceptive devices (IUCDs), abortions, artificial inseminations, and other miscellaneous thwartings of natural selection make it clear that man of the future will be conceived, in principle, by a computer. The change will be most welcome. The awkward requirement and preposterous idea that the son should resemble the father will disappear. Up (or down) in Madison, Wis, there's the Genetic Mating Service, which will match up the cow with the perfect sire. Their IBM-300 ticks off the lady's qualifications and high points. Then they reach into their liquid nitrogen frozen storehouse, and pull out the frozen semen of the perfect daddy, ideal to bolster the lady's weaknesses, genetically certain to eliminate all inborn errors of metabolism. This accomplished, there's a small laboratory exercise that does away with all that libidinous nonsense called sex, and the perfect junior
Contribution of immune response to the hepatic fibrosis induced by porcine serum
Authors: E Bhunchet, Y Eishi, K Wake
Journal: Hepatology (1996)

To investigate whether hepatic fibrosis induced by porcine serum in rats is caused by an immune reaction to porcine serum, rats that were immunologically tolerant exclusively to porcine serum were subjected to the repeated injection of porcine serum over a long period. This porcine serum-tolerant group consisted of 15 Wistar rats that had been injected intraperitoneally with porcine serum twice a week from the first postnatal day for 18 weeks. The control group consisted of 16 Wistar rats, aged 8 weeks, that were injected intraperitoneally with porcine serum twice a week for 10 weeks. Livers were fixed and examined by light microscopy. The serum of each rat was subjected to indirect enzyme-linked immunosorbent assay (ELISA) to measure the level of antibody to porcine albumin. In addition, immunohistochemical staining for ED1 was performed on untreated normal and porcine serum-induced fibrotic rat livers to examine the distribution of macrophages and their precursors, the monocytes. All rats in the tolerant group showed an extremely low antibody level (x = 68.27 +/- 4.53), and none (0/15) developed hepatic fibrosis. The majority of rats in the control group showed a very high antibody level (x = 1242.19 +/- 201.15); 75 percent (12/16) developed hepatic fibrosis. Data indicate that, despite the prolonged, repeated injections of porcine serum, if an immune response to porcine serum does not occur, the rats do not develop hepatic fibrosis. The porcine serum-tolerant rats developed hepatic fibrosis after 4 weeks of CCl4 treatment, indicating that injection of porcine serum into neonatal rats did not cause anergy of fibrogenesis, thereby preventing the animal from developing hepatic fibrosis. In normal rat liver, ED1-positive cells, which include nearly all Kupffer cells, were located pre-dominantly in the periportal area. In fibrotic rat liver, ED1-positive cells aggregated prominently in the newly formed and advanced connective tissue septa developed mainly between the neighboring central veins, and in fibrotic parts of the liver capsule. Aggregation of ED1-positive cells was rarely observed in nonfibrotic parts of the liver capsule. The difference between normal and fibrotic rat liver in distribution of EDl-positive cells suggests an involvement of macrophages in fibrogenesis and septum formation. In conclusion, our study showed a significant contribution by the immune response to porcine serum antigens leading to porcine serum-induced rat hepatic fibrosis--processes in which macrophages may be important. This study may lead to an understanding of the mechanism responsible for this form of experimental hepatic fibrosis.
TCT-207 Angiographic efficacy of Everolimus versus Resolute Zotarolimus - Eluting Stent in Long or Diabetic Coronary Artery Disease: Result from LONG-DES III, IV, ESSENCE-DIABETES I, and II trials
Authors: Jung-Min Ahn, Hyo In Choi, Hanul Choi, Hyun Kuk Kim, Pil Hyung Lee, Jae Hyung Roh, Young-Rak Cho, Won-Jang Kim, Jong-Young Lee, Soo-Jin Kang, Duk-Woo Park, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2013)
Hypercalcemia and Unilateral Nephrocalcinosis
Authors: Hiroo H. Advani
Journal: JAMA (1975)

PERSISTENT hypercalcemia is frequently associated with widespread metastatic calcification, most commonly in the kidneys, lungs, gastric mucosa, and blood vessels. This selective localization is believed to be due to unique physiological factors. Major pathological alterations in the function of these tissues may be expected to alter the distribution of calcium salt deposition. We are reporting a case in which nephrocalcinosis was largely confined to one kidney. It is our opinion that differences in the state of tubular glomerular function are responsible for this differential localization of calcium. <h3>Report of a Case</h3> A 51-year-old man was admitted to the New York Veterans Administration Hospital in August 1973 because of weight loss and pain in the lower back and left thigh, of several months' duration. Transurethral resections on two occasions and finally a partial cystectomy in September 1972 were performed for a transitional cell carcinoma of the urinary bladder diagnosed by cystoscopic
Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration
Authors: Fazilat F. Mohammed, Caroline J. Pennington, Zamaneh Kassiri, Jeffrey S. Rubin, Paul D. Soloway, Ulrich Ruther, Dylan R. Edwards, Rama Khokha
Journal: Hepatology (2005)

Liver regeneration depends on timely restoration of cellular mass while orchestrating structural matrix remodeling. Matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) are known to regulate the extracellular matrix (ECM) turnover and, more recently, the processing of growth factors and cytokines. We have previously demonstrated that TIMP-1 inhibits preneoplastic hepatocyte proliferation by attenuating growth factor bioavailability. In the present study, we examined the role of TIMP-1 in de novo hepatocyte cell division during liver regeneration. Comprehensive real-time reverse-transcriptase polymerase chain reaction analyses of regenerating livers revealed significant inductions in the messenger RNA of TIMP-1, TIMP-3, TIMP-4, MMP-2, MMP-9, MMP-13, MMP-14, and MMP-24, while MMP-15 expression was significantly reduced. Induction of TIMP-1 occurred during the peak of hepatocyte DNA synthesis. Studies using genetically altered mice revealed that TIMP-1 loss of function accelerated hepatocyte cell cycle progression. This finding was demonstrated by earlier expression of cyclin D1, proliferating cell nuclear antigen, and phosphorylated histone H3, which mark the G1-S, S, and M phase, respectively. Conversely, TIMP-1 gain of function delayed cell cycle progression. MMP activity was increased in the absence of Timp-1. Examination of hepatocyte growth factor (HGF), and its receptor Met, both of which provide a mitogenic signal for hepatocyte division, showed increased HGF activity in Timp-1−/−–regenerating livers. HGF is released from the ECM and is proteolytically processed to its active form. Active HGF was elevated in Timp-1−/− mice, leading to increased immunostaining of phosphorylated Met as well as activation of a downstream effector, p38. In conclusion, TIMP-1 is a novel negative regulator of HGF activity during liver regeneration. (HEPATOLOGY 2005.)
Changes in Prescribing Patterns Following Publication of the ALLHAT Trial
Authors: P. C. Austin
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Increasing Prevalence of Antimicrobial Resistance Among Uropathogens Causing Acute Uncomplicated Cystitis in Women
Authors: Kalpana Gupta
Journal: JAMA (1999)

ContextGuidelines for the management of acute uncomplicated cystitis in women that recommend empirical therapy in properly selected patients rely on the predictability of the agents causing cystitis and knowledge of their antimicrobial susceptibility patterns.ObjectiveTo assess the prevalence of and trends in antimicrobial resistance among uropathogens causing well-defined episodes of acute uncomplicated cystitis in a large population of women.DesignCross-sectional survey of antimicrobial susceptibilities of urine isolates collected during a 5-year period (January, May, and September 1992-1996).SettingHealth maintenance organization.PatientsWomen aged 18 to 50 years with an outpatient diagnosis of acute cystitis.Main Outcome MeasuresProportion of uropathogens demonstrating in vitro resistance to selected antimicrobials; trends in resistance over the 5-year study period.ResultsEscherichia coli and Staphylococcus saprophyticus were the most common uropathogens, accounting for 90% of the 4342 urine isolates studied. The prevalence of resistance among E coli and all isolates combined was more than 20% for ampicillin, cephalothin, and sulfamethoxazole in each year studied. The prevalence of resistance to trimethoprim and trimethoprim-sulfamethoxazole rose from more than 9% in 1992 to more than 18% in 1996 among E coli, and from 8% to 16% among all isolates combined. There was a statistically significant increasing linear trend in the prevalence of resistance from 1992 to 1996 amongE coli and all isolates combined to ampicillin (P&lt;.002), and to cephalothin, trimethoprim, and trimethoprim-sulfamethoxazole (P&lt;.001). In contrast, the prevalence of resistance to nitrofurantoin, gentamicin, and ciprofloxacin hydrochloride was 0% to 2% among E coli and less than 10% among all isolates combined, and did not change significantly during the 5-year period.ConclusionsWhile the prevalence of resistance to trimethoprim-sulfamethoxazole, ampicillin, and cephalothin increased significantly among uropathogens causing acute cystitis, resistance to nitrofurantoin and ciprofloxacin remained infrequent. These in vitro susceptibility patterns should be considered along with other factors, such as efficacy, cost, and cost-effectiveness in selecting empirical therapy for acute uncomplicated cystitis in women.
Designer natriuretic peptides.
Authors: D G Gardner
Journal: Journal of Clinical Investigation (1993)

The natriuretic peptides continue to amaze researchers in the field with their diversity of biological activity, ranging from reduction ofblood pressure through regulation ofrenal tubular sodium handling to modulation ofneuronal activity in the cen- tral nervous system (1).The article by Wei et al. ( 2) in the present issue of the Journal would suggest that even now we do not completely understand, nor have we fully exploited, all of the biological properties that these peptides have at their disposal.
Retraction of: abstract P134, Increased beta-adrenergic inotropy in ventricular myocardium from Trpm4 knockout mice
Authors: M. Kecskes, I. Mathar, J. Griet, G. Van Der Mieren, T. Voets, P. Herijgers, R. Vennekens
Journal: Cardiovascular Research (2014)

The publication of this meeting abstract has been retracted at the request of the authors because of prior publication of the full report in Circulation Research.
Developmental Changes in PON1 Enzyme Activity in Young Children and Effects of PON1 Polymorphisms
Authors: Karen Huen, Kim Harley, Jordan Brooks, Alan Hubbard, Asa Bradman, Brenda Eskenazi, Nina Holland
Journal: Environmental Health Perspectives (2009)

Paraoxonase 1 (PON1) is an enzyme that detoxifies activated organophosphorus pesticides (OPs) and is also involved in oxidative stress pathways.PON1 activity in newborns is lower than in adults, but the ontogeny of PON1 activity is poorly characterized in young children. We examined the effects of age and PON1 genotype on enzyme activity in a birth cohort of Mexican-American children.We determined three substrate-specific measures of PON1 activity in 1,143 plasma samples collected longitudinally from 458 children at five time points from birth through 7 years of age, and genotyped PON1 polymorphisms at positions 192 and -108 in these children.Contrary to previous reports that PON1 activities plateau by 2 years of age, we observed an age-dependent increase in all three PON1 measures from birth through 7 years of age (p < 0.0001). The PON1(192) genotype significantly modified the effect of age on paraoxonase (POase) activity (p < 0.0001) such that increases in enzyme activity with age were influenced by the number of R alleles in a dose-dependent manner. Children with the PON1(-108CC192RR) diplotype had significantly higher mean PON1 activities and also experienced steeper increases of POase activity over time compared with children with the PON1(-108TT192QQ) diplotype.Lower levels of the PON1 enzyme, which is involved in protection against OPs and oxidative stress, persist in young children past 2 years of age through at least 7 years of age. Future policies addressing pesticide exposure in children should take into account that the window of vulnerability to OPs in young children may last beyond infancy.
Health secretary is accused of demanding "politically driven" raids on abortion clinics
Authors: I. Torjesen
Journal: BMJ (2012)

Andrew Lansley has been accused of ordering the Care Quality Commission to abandon its other work and conduct an unjustified and “politically driven” series of unannounced inspections at abortion clinics this week.

On 23 March Ann Furedi, chief executive of the British Pregnancy Advisory Service (BPAS), told the BBC Radio 4 programme Today that Lansley had told the CQC to prioritise up to 500 unannounced inspections at NHS and private abortion clinics in England. So far around 250 have taken place.

The inspectors have been looking for evidence that doctors have been pre-signing abortion consent forms. Under abortion law, …
Lipoic acid prevents development of the hyperdynamic circulation in anesthetized rats with biliary cirrhosis
Authors: Richard Marley, Steve Holt, Bimbi Fernando, David Harry, Radhi Anand, David Goodier, Susan Davies, Kevin Moore
Journal: Hepatology (1999)

Chronic bile duct ligation is associated with the development of oxidant injury, biliary cirrhosis, portal hypertension, and a hyperdynamic circulation. We have previously demonstrated that the hyperdynamic circulation in the partial portal vein-ligated rat can be prevented by the administration of N –acetylcysteine. To extend these findings, we have examined the effect of lipoic acid, a thiol–containing antioxidant, on hemodynamics, oxidative stress, and nitric oxide (NO) production in bile duct-ligated (BDL) cirrhotic rats. Lipoic acid was given continuously in drinking water to normal and BDL rats; control rats received ordinary drinking water, and animals were studied at 24 days following surgery. Lipoic acid prevented the development of the hyperdynamic circulation (cardiac index [CI]: 15.7 ± 2.0 vs. 29.5 ± 2.1 mL · min -1 · 100 g -1 ; P &lt; .05) and significantly attenuated the rise in portal pressure (PP) (12.7 ± 0.8 vs. 15.2 ± 0.5 mm Hg; P &lt; .05). Hepatic nitric oxide synthase (NOS) activity and plasma nitrite/nitrate concentration increased significantly following bile duct ligation, and both of these were prevented by lipoic acid. Lipoic acid had no effect on the biochemical or histological parameters of liver function in the cirrhotic group. We conclude that lipoic acid prevents the development of the hyperdynamic circulation in the rat model of biliary cirrhosis, and that this is associated with decreased synthesis of NO.(Hepatology 1999;29:1358–1363.)
Prevalence and Associated Features of Albuminuria in Koreans with NIDDM
Authors: Ki-Up Lee, Joong Y Park, Sang W Kim, Mee H Lee, Ghi S Kim, Su-Kil Park, Jung-Sik Park
Journal: Diabetes Care (1995)

OBJECTIVE To determine the prevalence and the associated features of microalbuminuria and overt proteinuria in Korean subjects with non-insulin-dependent diabetes mellitus (NIDDM) attending a hospital clinic. RESEARCH DESIGN AND METHODS A total of 631 Korean outpatients with NIDDM were studied cross-sectionally for the presence of albuminuria and other micro- and macrovascular complications. Urinary albumin excretion rate (AER) was determined in timed overnight urine samples. Subjects were divided into three groups: no nephropathy (AER &amp;lt;20 μg/min), microalbuminuria (AER 20–200 μg/min), and overt proteinuria (AER &amp;gt;200 μg/min). RESULTS Increased AER was present in 34% of our patients: 20% had microalbuminuria and 14% had overt proteinuria. Of patients with diabetes duration ≥ 15 years, 35% had overt proteinuria. Most (82%) patients with overt proteinuria had retinopathy. Although the prevalence of microalbuminuria as a whole did not differ according to diabetes duration, the prevalence of microalbuminuria in the patients with retinopathy increased with diabetes duration. The microalbuminuric patients without retinopathy (diabetes duration &amp;lt; 5 years) were characterized by higher prevalence of hypertension and previous obesity, higher plasma triglyceride level, and lower plasma high-density lipoprotein cholesterol level. CONCLUSIONS The prevalence of overt proteinuria in Korean NIDDM patients with a long diabetes duration was higher than that reported in Caucasians. Our data also suggest that the clinical meaning of microalbuminuria may be different based on the presence or the absence of retinopathy. Microalbuminuria in patients with retinopathy most probably would reflect diabetic nephropathy. In contrast, some recent-onset NIDDM patients with microalbuminuria in the absence of retinopathy had features of syndrome X.
N-(4-hydroxyphenyl)retinamide induces growth arrest and apoptosis in HTLV-I-transformed cells
Authors: N Darwiche, A Hatoum, G Dbaibo, H Kadara, R Nasr, G Abou-Lteif, R Bazzi, O Hermine, H de Thé, Ali Bazarbachi
Journal: Leukemia (2003)
Hypothermia and Wernicke's encephalopathy.
Authors: J M Hunter
Journal: BMJ (1976)

and liver enzymes were normal.Patch tests for Quinaband gave negative results.Application of Quinaband was stopped, and on 24 November 2 units of fresh blood produced a rapid rise in platelet count, which subsequently returned to normal values.The patient made an excellent recovery and remained euthyroid, though the leg ulcers posed considerable problems.
(48) Waldenstrom's hyperglobulinaemic purpura associated with Sjogren's syndrome
Authors: H. McGrath, D. Slater
Journal: British Journal of Dermatology (1986)

Journal Article (48) Waldenstrom's hyperglobulinaemic purpura associated with Sjogren's syndrome Get access H. McGrath, Drs, H. McGrath, Drs Doncaster Royal Infirmary and Rotherham District General Hospital Search for other works by this author on: Oxford Academic Google Scholar D. Slater D. Slater Doncaster Royal Infirmary and Rotherham District General Hospital Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 115, Issue s30, 1 July 1986, Pages 91–92, https://doi.org/10.1111/j.1365-2133.1986.tb07743.x Published: 01 July 1986
Modern Trends in Surgery.
Authors: August P. Hovnanian
Journal: JAMA (1963)

This small monograph contains 14 chapters which deal with the recent advances in the diagnosis, treatment, and prognosis of different diseases and their complications in the surgical field. Each chapter is concisely handled and the issues are discussed very lucidly. The first four chapters, dealing with the gastrointestinal tract and its appendages, are followed by two chapters on vascular surgery. Treatment of cancer of the breast, renal transplantation, hypothermia, and regional perfusions with cytotoxic drugs are each given due consideration. The remaining four chapters deal with basic auxiliary problems in surgery, such as fluid and electrolyte problems, acid-base balance, blood transfusion and wound healing. Bibliographic documentation is well chosen and comprehensive. Although the editor states in the foreword that no attempt has been made in this book to review the whole field of general surgery, one wonders why problems of shock, burns, various cytodiagnostic techniques and the antibiotics, to mention
Doctors Serving People: Restoring Humanism to Medicine Through Student Community Service
Authors: Deborah I. Allen
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Smoking, lung function, and rheumatoid factors.
Authors: T Tuomi, M Heliovaara, T Palosuo, K Aho
Journal: Annals of the Rheumatic Diseases (1990)

Positive rheumatoid factor (RF) reactions commonly precede the onset of clinically manifest rheumatoid arthritis (RA). Thus if items associated with RF reactions were traced at the community level this might provide clues to the cause of RA. The relations between smoking and lung functions and the occurrence of RA and RFs in a population sample representative of the adult Finnish population were studied. Rheumatoid factor testing was performed for 7124 subjects (89% of the sample) by the sensitised sheep cell agglutination test. Forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) were measured with spirometry. 9False positive9 RF reactions occurred twice as often in current smokers and ex-smokers than in those who had never smoked. The prevalence of high titres was fourfold greater among current smokers than among those who had never smoked. These associations were statistically significant and independent of age, FVC, and FEV1 in both sexes. The women with airflow limitation (FEV1/FVC less than 70%) had a significantly increased occurrence of RFs which was independent of their smoking history, but no such relationship was found in men. The results suggest an impact of smoking on RF production; a follow up study may show whether the raised RF titers in smokers will be reflected as an increased incidence of RA.