BIOCHEMICAL ANOMALIES IN SCHIZOPHRENIA
Authors: PAUL W. CLOUGH
Journal: Annals of Internal Medicine (1959)

Editorial1 September 1959BIOCHEMICAL ANOMALIES IN SCHIZOPHRENIAPAUL W. CLOUGH, M.D.PAUL W. CLOUGH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-3-622 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe great frequency of schizophrenia, from five to eight per thousand of the general population, the devastating effect on the individual and on the family, the lack of any effective therapy, and the huge cost of lifelong care for hundreds of thousands of victims all make this a problem of truly major importance. Hitherto most progress has been made in clinical psychiatric studies. Even here, however, it may be difficult in the early stages to distinguish promptly between acute cases manifesting transient schizoid reactions to emotional stress of great severity, such as were seen in the military services, for example,...1 Page IH: Neurochemistry and serotonin: a chemical fugue, Ann. New York Acad. Sc. 66: 592-601, 1956-57. CrossrefGoogle Scholar2 Kety SS: Biochemical theories of schizophrenia, Science 129: 1528-1532 (June 5) 1959; 1590-1596 (June 12) 1959. CrossrefMedlineGoogle Scholar3 HofferOsmond AH: The adrenochrome model and schizophrenia, J. Nerv. and Ment. Dis. 128: 18-35, 1959. CrossrefMedlineGoogle Scholar4 McGeerMcNairMcGeerGibson PLFEEGWC(a) : Aromatic metabolism in schizophrenia. I. Statistical evidence for aromaturia, J. Nerv. and Ment. Dis. 125: 166-175, 1957. (b) McGeer, E. G., Brown, W. T., and McGeer, P. L.: Aromatic metabolism in schizophrenia. II. Bidimensional urinary chromatograms, J. Nerv. and Ment. Dis. 125: 176-180, 1957. MedlineGoogle Scholar5 GreinerBurchEdelburg TNRR: Psychopathology and psychophysiology of minimal LSD-25 dosage, Arch. Neurol. and Psychiat. 79: 208-210, 1958. CrossrefGoogle Scholar6 Rothlin E: Lysergic acid diethylamide and related substances, Ann. New York Acad. Sc. 66: 663-676, 1956-57. Google Scholar7 ApterPfeiffer JTCC: The effect of the hallucinogenic drugs LSD-25 and mescaline on the electroretinogram, Ann. New York Acad. Sc. 66: 508-513, 1956-57. CrossrefGoogle Scholar8 AxelrodBradyWitkopEvarts JROBEV: The distribution and metabolism of lysergic acid diethylamide, Ann. New York Acad. Sc. 66: 435-444, 1956-57. CrossrefGoogle Scholar9 WoolleyShaw DWEN(a) : A biochemical and pharmacological suggestion about certain mental disorders, Science 119: 587, 1954. (b) Woolley, D. W., and Shaw, E. N.: Evidence for the participation of serotonin in mental processes, Ann. New York Acad. Sc. 66: 649-665, 1956-57. Google Scholar10 Gaddum JH: Serotonin-LSD interactions, Ann. New York Acad. Sc. 66: 643-647, 1956-57. CrossrefGoogle Scholar11 BrodieShore BBPA: A concept for a role of serotonin and norepinephrin as chemical mediators in the brain, Ann. New York Acad. Sc. 66: 631-642, 1956-57. CrossrefGoogle Scholar12 LeachHeath BERG: The in vitro oxidation of epinephrin in plasma, Arch. Neurol. and Psychiat. 76: 444-450, 1956. CrossrefGoogle Scholar13 Akerfeldt S: Oxidation of N,N-dimethyl-p-phenylenediamine by serum from patients with mental disease, Science 125: 117-119, 1957. CrossrefMedlineGoogle Scholar14 LeachCohenHeathMartens BEMRGS: Studies on the role of ceruloplasmin and albumin in adrenaline metabolism, Arch. Neurol. and Psychiat. 76: 635-641, 1956. CrossrefGoogle Scholar15 HeathMartensLeachCohenAngel RGSBEMC: Effect on behavior in humans with the administration of taraxein, Am. J. Psychiat. 114: 14, 1957. CrossrefMedlineGoogle Scholar16 Leif HI: The effect of taraxein on a patient in analysis, Arch. Neurol. and Psychiat. 78: 624-627, 1957. CrossrefGoogle Scholar17 Osmond H: A review of the clinical effects of the psychotomimetic agents, Ann. New York Acad. Sc. 66: 418-434, 1956-57. CrossrefGoogle Scholar18 Hoffer A: Adrenochrome in blood plasma, Am. J. Psychiat. 114: 752-753, 1958. CrossrefMedlineGoogle Scholar19 SzaraAxelrodPerlin SJS: Is adrenochrome present in the blood?, Am. J. Psychiat. 116: 162, 1958. CrossrefGoogle Scholar20 La BrosseAxelrodKety EHJSS: O-methylation the principal route of metabolism of epinephrine in man, Science 128: 593-594, 1958. CrossrefMedlineGoogle Scholar21 OsmondHoffer HA: A small research in schizophrenia, Canad. M. A. J. 80: 91-94, 1959. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1959Volume 51, Issue 3Page: 622-628KeywordsArmed forcesEmotionsSchizophrenia Issue Published: 1 September 1959 PDF downloadLoading ...