tbuckley/cabot-search huggingface dataset:
Cancer incidence among patients with ankylosing spondylitis in Sweden 1965-95: a population based cohort study
Authors: N Feltelius
Journal: Annals of the Rheumatic Diseases (2003)

Ankylosing spondylitis (AS) is a chronic inflammatory joint disease which may lead to extra-articular complications. The disease associated cancer risk has been poorly explored. Recently, tumour necrosis factor alpha blockers have been found to be efficacious in AS, but their long term risk is unknown.To analyse a large national cohort of patients with AS to determine the overall cancer risk in AS as a background to the future introduction of new treatments.All patients with AS admitted to Swedish hospitals 1965-95 were linked through individual national registration numbers to the Swedish Cancer Register and National Death Register. Standardised incidence ratio (SIR) of cancer risk was calculated in 6621 people, monitored during 67 885 person-years.No overall increase in cancer risk was found (SIR 1.05, 95% CI 0.94 to 1.17). Rectal cancer was less common (SIR 0.41, 95% CI 0.15 to 0.89) while unspecified kidney cancer was more common (SIR 5.90, 95% CI 1.61 to 15.1). Risks for colon, renal parenchymal, and renal pelvic cancer were not significantly increased. Laryngeal cancer was more common than expected, while lung cancer was not. Risks of haematopoietic malignancies were not increased.No overall increase in cancer risk was found. The decreased risk of rectal cancer might be due to local application of NSAIDs, and the increased risk of unspecified kidney cancer to frequent radiological pelvic examinations. If information on disease characteristics, including HLA-B27, was available for individual patients with cancer, risk-benefit analysis of long term effects of new immunomodulation treatment might be improved.
Arsenic in drinking water and pregnancy outcomes.
Authors: S A Ahmad, M H Sayed, S Barua, M H Khan, M H Faruquee, A Jalil, S A Hadi, H K Talukder
Journal: Environmental Health Perspectives (2001)

We studied a group of women of reproductive age (15-49 years) who were chronically exposed to arsenic through drinking water to identify the pregnancy outcomes in terms of live birth, stillbirth, spontaneous abortion, and preterm birth. We compared pregnancy outcomes of exposed respondents with pregnancy outcomes of women of reproductive age (15-49 years) who were not exposed to arsenic-contaminated water. In a cross-sectional study, we matched the women in both exposed and nonexposed groups for age, socioeconomic status, education, and age at marriage. The total sample size was 192, with 96 women in each group (i.e., exposed and nonexposed). Of the respondents in the exposed group, 98% had been drinking water containing [Greater and equal to] 0.10 mg/L arsenic and 43.8% had been drinking arsenic-contaminated water for 5-10 years. Skin manifestation due to chronic arsenic exposure was present in 22.9% of the respondents. Adverse pregnancy outcomes in terms of spontaneous abortion, stillbirth, and preterm birth rates were significantly higher in the exposed group than those in the nonexposed group (p = 0.008, p = 0.046, and p = 0.018, respectively).
Bilateral Phaeochromocytoma Associated with Carcinoma of the Thyroid
Authors: U. Sahay
Journal: BMJ (1962)

oxylase, seems of particular interest and has to our knowledge not yet been tested in patients with the carcinoid syndrome.A definite reduction of the number of flushes and their duration in combination with deseril was observed in our patient.No hypotension or other adverse side-effects occurred with the two drugs.Another substance, alpha-methyl-3-4-dehydroxy-D-Lphenylalanine (M.K. 351, Nr.C-2294, Merck Sharp and Dohme, Rahway, N.J.), has shown definite suppression of the flushes in our patient without affecting the diarrhoea (Dubach and Blumberg, 1961 ; Collini, 1961).However, this latter serotonin antagonist caused alarming side- effects in the psychical behaviour of the patient, necessitating discontinuance of the drug.SUIIMMARY Two serotonin antagonists, l-methyl-D-lysergic acid butanolamide tartrate (UML 491 ; deseril) and 1-[pdimethylamino -benzyl] -2[5 -methyl -3 -isoxazolylcar- bonyl]-hydrazine (Ro 5-1025), were given by mouth to a patient with the carcinoid syndrome.The former drug reduced or stopped the diarrhoea; the latter, when given together with deseril, reduced the flushes from four to six to one to two a day.These effects were maintained over a period of several months to the benefit of the patient, who was able to continue to work up to one month before his death.No ill-effects of the two drugs were found.We are grateful to
Vivisection—A Reply to Dr. Keen.
Authors: James M. Brown
Journal: JAMA (1901)

Toledo, Ohio, Aug. 21, 1901. <h3>To the Editor:</h3> —I have read the communication of Dr. Keen, published in your issue of August 10, and already applications have been made by members of the medical profession for literature concerning the subject of the controversy—human vivisection. As the American Humane Association considers this matter one of vital importance, its executive committee has, after amendment and revision, just printed that Review of Dr. Keen's letter upon which he, in his last communication, comments; and in order to do him justice, the Association has added his first letter, which he has called "The Misstatements of Antivivisectionists." These two documents in one pamphlet can be secured gratis by any physician in the United States who will send his professional card to "The Special Committee," Postoffice Box 215, Providence, R. I. For those medical men who carefully read this pamphlet, it would seem to me that
He no look good
Authors: G. Dunea
Journal: BMJ (1995)

During the day hospitals are bustling places where armies of doctors, computer terminals, and people with suspect job descriptions constantly interact in many different languages and jargons. But at night the communication superhighway comes to an abrupt end; the armies melt away; and the cadets take over while their generals and aides de camp sleep.

Nor do they always appreciate having their sleep interrupted. A colleague of mine remembers how during her first week as an intern she had to take care at night of a patient with florid lupus erythematosus. Unable to find her resident, she phoned her attending physician— a distinguished professor—at his home. She was screamed at and told never again to call after midnight. …
Monovalent Type 1 Oral Poliovirus Vaccine in Newborns
Authors: Nasr El-Sayed, Yehia El-Gamal, Ahmed-Amr Abbassy, Iman Seoud, Maha Salama, Amr Kandeel, Elham Hossny, Ahmed Shawky, Heba Abou Hussein, Mark A. Pallansch, Harrie G.A.M. van der Avoort, Anthony H. Burton, Meghana Sreevatsava, Pradeep Malankar, Mohamed H. Wahdan, Roland W. Sutter
Journal: New England Journal of Medicine (2008)

In 1988, the World Health Assembly resolved to eradicate poliomyelitis. Although substantial progress toward this goal has been made, eradication remains elusive. In 2004, the World Health Organization called for the development of a potentially more immunogenic monovalent type 1 oral poliovirus vaccine.
To treat or not to treat: hyperprolactinemia
Authors: Elizabeth Rasche González
Journal: JAMA (1982)

Physicians are overtreating hyperprolactinemia, says Michele C. S. Koppelman, MD, of the National Institute of Child Health and Development (NICHD), Bethesda, Md. At the recent meeting of the Endocrine Society in San Francisco, Koppelman reported on a follow-up study of 25 female patients with long-standing, untreated hyperprolactinemia. Most of the patients' conditions remained stable or improved clinically over the years, and some showed apparent regression of pituitary adenomas. On average, the onset of the patients' symptoms predated the follow-up study by 11.3 years and the diagnoses of hyperprolactinemia by 5.3 years. Half of the women had had initial serum prolactin levels higher than 200 ng/mL, and two thirds had had levels exceeding 100 ng/mL. In 15 patients, skull x-ray films and polytomography of the pituitary fossa had shown abnormalities in the sella turcica. None of the patients with these abnormalities had visual field defects, but several had headaches. At the
Continuing Lessons from Glycogen Storage Diseases
Authors: R. Rodney Howell
Journal: New England Journal of Medicine (1991)

INHERITED abnormalities of glycogen metabolism were recognized very early, because pathologists could identify gross accumulations of glycogen in tissues during postmortem examinations. The specific patterns of tissue involvement permitted recognition of a number of clinical types of glycogen storage disease long before the biochemical pathways had been identified and the specific causes of the inborn errors of metabolism understood.The study of tissue-biopsy specimens from patients with glycogen storage diseases taught us the value of studying enzymatic reactions to identify human genetic disease. In 1952 Cori and Cori identified a deficiency of glucose-6-phosphatase activity in liver tissue obtained by biopsy . . .
Seropositivity for HIV at Alternate Sites
Authors: J. C. Grabau, D. L. Morse
Journal: JAMA (1988)

<h3>To the Editor.—</h3> Shortly after the Food and Drug Administration licensed thetubeenzyme-linked immunosorbent assay for human immunodeficiency virus (HIV) testing, the Centers for Disease Control made funds available for the development and implementation of "alternate testing sites." The goal of the program was to protect the nation's blood supply by providing individuals with an anonymous HIV counseling and testing service outside the blood bank system.<sup>1</sup>The first anonymous HIV counseling and testing site in New York State opened in mid-1985. Starting in January 1986, all persons tested were asked to complete a blinded questionnaire that collected data on demographics and HIV risk behaviors.<sup>2</sup> Between the inception of the program and December 1987, the results of 17 724 tests were provided to clients in Upstate New York (ie, New York State exclusive of New York City), with a seropositivity rate of 7.6%. However, that rate varied from 14.5%
Raumverlust als pathogenetisches, Raumgewinnung als psychotherapeutisches Problem
Authors: W. Schulte
Journal: Psychotherapy and Psychosomatics (1963)

Research Articles| February 10 2010 Raumverlust als pathogenetisches, Raumgewinnung als psychotherapeutisches Problem Subject Area: Psychiatry and Psychology W. Schulte W. Schulte Aus der Universitäts-Nervenklinik Tübingen (Direktor: Prof. Dr. W. Schulte) Search for other works by this author on: This Site PubMed Google Scholar Acta Psychotherapeutica et Psychosomatica (1963) 11 (6): 430–444. https://doi.org/10.1159/000285695 Article history Published Online: February 10 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation W. Schulte; Raumverlust als pathogenetisches, Raumgewinnung als psychotherapeutisches Problem. Acta Psychotherapeutica et Psychosomatica 1 June 1963; 11 (6): 430–444. https://doi.org/10.1159/000285695 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Psychotherapeutica et Psychosomatica Search Advanced Search Article PDF first page preview Close Modal This content is only available via PDF. 1963Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
The Diabetic Foot
Authors: Zachary T. Bloomgarden
Journal: Diabetes Care (2008)

Perspectives on the News commentaries are part of a free monthly CME activity.The Mount Sinai School of Medicine, New York, New York, designates this activity for 2.0 AMA PRA Category 1 credits.If you wish to participate, review this article and visit www.diabetes.procampus.net to complete a posttest
GMC finds doctors not guilty in consent case
Authors: C. Court
Journal: BMJ (1995)

Three psychiatrists were found not guilty of serious professional misconduct by the General Medical Council, the body that regulates British doctors, last week in a case that centred on the issue of patient consent and confidentiality (see editorial, p 1240). The complainant had been the subject of a case report submitted by the doctors to a specialist medical journal, and she claimed that the report contained so much detail that she could be identified from it.

The report, which concerned people with bulimia nervosa who bleed themselves, was entitled “Blood-letting in bulimia nervosa” and was published in the British Journal of Psychiatry (1993;162:246-8). The authors were consultant psychiatrist Dr John Eagles and psychiatric registrar Dr Jon Richard Parkin, who were both working at the time at the Royal Cornhill Hospital in Aberdeen. The article also acknowledged thanks to Dr Alistair Palin for “allowing us to report on one of his patients.” Consultant psychiatrist Dr Palin also worked at the Royal Cornhill, and he was the third doctor involved in the hearing.

The complainant, known throughout the three day hearing as “Miss C,” claimed that Dr Parkin had asked to interview her …
Many claims about passive smoking are inadequately justified
Authors: P. N Lee
Journal: BMJ (1997)

Editor–George Davey Smith and Andrew N Phillips suggest that the tobacco industry attempts to promote confusion about passive smoking and disease.1 Although I was not involved with the report of the European Working Group on Environmental Tobacco Smoke and Lung Cancer, their central concern, I am cited as an “enthusiastic recipient of tobacco industry financial support who … has presented models … most favourable to the tobacco industry case.” Insinuating that I distort evidence for money is most unfair. I am widely consulted on many issues …
Abstract 1179: Macrophage conditioned media increases the expression of a metastasis-associated oncogene, RhoC, and the migration of inflammatory breast cancer cells
Authors: Chelsea L. Fournier, Steven G. Allen, Yu-Chih Chen, Euisik Yoon, Sofia D. Merajver
Journal: Cancer Research (2014)

Abstract Inflammatory breast cancer (IBC) is the most lethal form of breast cancer because it progresses rapidly and often presents with distant metastases at diagnosis. RhoC GTPases, known to play an important role in the movement of cells, are overexpressed in IBC tumor cells. The mechanism that causes this increase in RhoC expression is unknown. Tumor associated macrophages (TAMs) have been found to facilitate the movement and invasion of breast cancer. Therefore, as a component of the immune system attracted to sites of inflammation, we hypothesized that TAMs play a role in increasing RhoC expression in IBC cells, which consequently leads to IBC's severe migratory and metastatic capabilities. The expression of RhoC increased in two different IBC cell lines, SUM149 and SUM190, in the presence of conditioned media (CM) from macrophage-differentiated U937 cells. This increase was not observed in either the normal-like MCF-10A cell line or the non-IBC MDA-MB-231 breast cancer cell line. From this observation, a novel microfluidic device allowed the study of the migratory phenotype of individual cells of the two IBC cell lines in response to standard chemoattractants as well as the macrophage CM. As expected, the presence of a serum gradient promoted the chemotaxis of IBC cells versus serum-free control. A CM gradient also increased the migration of IBC cells to a moderate degree. However, in the overlapping presence of CM without a gradient and serum with a gradient, the cells exhibiting an extreme migratory phenotype migrated roughly twice the distance of the serum gradient control. We believe the CM acts to “prime” the IBC cells in order to manifest an ultra-response to the serum chemoattractant. In both IBC cell lines stably-transfected with shRNA targeted to RhoC, we observed decreased migration when exposed to the CM migration conditions. Therefore, RhoC expression is necessary for this increase in migration. Studies involving RhoC inhibitors are ongoing, but could yield promising therapies for the prevention of metastasis of IBC. Future studies will aim to identify which cytokines in the CM and which specific pathways are responsible for the increased RhoC expression and migration of IBC cells. By understanding the specific mechanism of TAMs' effects on IBC cells we hope to learn better how to control the lethal metastatic nature of inflammatory breast cancer. Citation Format: Chelsea L. Fournier, Steven G. Allen, Yu-Chih Chen, Euisik Yoon, Sofia D. Merajver. Macrophage conditioned media increases the expression of a metastasis-associated oncogene, RhoC, and the migration of inflammatory breast cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1179. doi:10.1158/1538-7445.AM2014-1179
Evidence for a role for Gαi1 in mediating weak agonist-induced platelet aggregation in human platelets: reduced Gαi1 expression and defective Gi signaling in the platelets of a patient with a chronic bleeding disorder
Authors: Yatin M. Patel, Kirti Patel, Salman Rahman, Mark P. Smith, Gillian Spooner, Rushika Sumathipala, Michael Mitchell, Geraldine Flynn, Alexandra Aitken, Geoffrey Savidge
Journal: Blood (2003)
The Medical Consultant's Role in Caring for Patients with Hip Fracture
Authors: Kiran G. Zaveri
Journal: Annals of Internal Medicine (1999)

Letters5 January 1999The Medical Consultant's Role in Caring for Patients with Hip FractureKiran G. Zaveri, MDKiran G. Zaveri, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-1-199901050-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Morrison and colleagues' review on the medical consultant's role in the care of patients with hip fracture (1) was very interesting and thorough. Despite this and many other articles, however, prophylactic management of deep venous thrombosis is far from clear. Weight-adjusted low-molecular-weight heparin therapy is probably not necessary, and fixed-dose low-molecular-weight heparin may become standard of practice, as reinforced by Haentjens (2). Although Morrison and associates suggested starting low-molecular-weight heparin before surgery, at present data are limited. Studies are unequivocal, however, about postoperative therapy with enoxaparin sodium (3). Noble and colleagues reported that enoxaparin, 40 mg once ...References1. Morrison RS, Chassin MR, Sin AL. The medical consultant's role in caring for patients with hip fracture. Ann Intern Med. 1998;128:1010-20. LinkGoogle Scholar2. Haentjens P. A comparison between a fixed dose and an individually adjusted dose of a low molecular weight heparin. Thromb Haemost. 1996;75:239-41. MedlineGoogle Scholar3. Noble S, Peter DH, Goa KL. Enoxaparin. A reappraisal of its pharmacology and clinical applications in the prevention and treatment of thromboembolic disease. Drugs. 1995;49:388-410. CrossrefMedlineGoogle Scholar4. Wicky J, Bongard O, Peter R, Simonovska S, Bounameaux H. Screening for proximal deep venous thrombosis using B-mode venous ultrasonography following major hip surgery: implications for clinical management. Vasa. 1994;23:330-6. MedlineGoogle Scholar5. Lin PP, Graham D, Hann LE, Boland PJ, Healey JH. Deep venous thrombosis after orthopedic surgery in adult cancer patients. J Surg Oncol. 1998;68:41-7. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Kiran G. Zaveri, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Medical Consultant's Role in Caring for Patients with Hip Fracture R. Sean Morrison , Mark R. Chassin , and Albert L. Siu The Medical Consultant's Role in Caring for Patients with Hip Fracture R. Sean Morrison , Mark R. Chassin , MPP , and Albert L. Siu Metrics 5 January 1999Volume 130, Issue 1Page: 76KeywordsDeep vein thrombosisHeparinHipHip fracturesLow molecular weight heparinPatientsSodiumSurgery ePublished: 15 August 2000 Issue Published: 5 January 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Positive and negative affect and risk of coronary heart disease: Whitehall II prospective cohort study
Authors: H. Nabi, M. Kivimaki, R. D. Vogli, M. G Marmot, A. Singh-Manoux
Journal: BMJ (2008)

<b>Objective</b> To examine the associations between positive and negative affect and subsequent coronary heart disease events independently of established risk factors. <b>Design</b> Prospective cohort study with follow-up over 12 years. <b>Setting</b> 20 civil service departments originally located in London. <b>Participants</b> 10 308 civil servants aged 35-55 years at entry into Whitehall II study in 1985. <b>Main outcome measures</b> Fatal coronary heart disease, clinically verified incident non-fatal myocardial infarction, and definite angina (n=619, mean follow-up 12.5 years). <b>Results</b> In Cox regression analysis adjusted for age, sex, ethnicity, and socioeconomic position, positive affect (hazard ratio=1.01, 95% confidence interval 0.82 to 1.24) and the balance between positive and negative affect, referred to as the affect balance score (hazard ratio=0.89, 0.73 to 1.09), were not associated with coronary heart disease. Further adjustment for behaviour related risk factors (smoking, alcohol consumption, daily fruit and vegetable intake, exercise, body mass index), biological risk factors (hypertension, blood cholesterol, diabetes), and psychological stress at work did not change these results. However, participants in the highest third of negative affect had an increased incidence of coronary events (hazard ratio=1.32, 1.09 to 1.60), and this association remained unchanged after adjustment for multiple confounders. <b>Conclusions</b> Positive affect and affect balance did not seem to be predictive of future coronary heart disease in men and women who were free of diagnosed coronary heart disease at recruitment to the study. A weak positive association between negative affect and coronary heart disease was found and needs to be confirmed in further studies.