tbuckley/cabot-search huggingface dataset:
A Canadian Perspective
Authors: James E Till
Journal: PLoS Medicine (2005)

Gatz's statement, "At least half of the explanation for individual differences in susceptibility to Alzheimer disease is genetic" [1], is, in my opinion, incorrect.As the one who led the team debating Ashford and Mortimer, whose 2002 article [2] supports this statement, at the 2001 conference on Alzheimer disease (AD) in Cincinnati ("Challenging Views of Alzheimer's Disease") [3], I think that the evidence that dietary and lifestyle factors explain the majority of the individual risk for AD in the US is very strong.My original paper in 1997 [4] found that total dietary fat and energy intake were the most important dietary risk factors, while fi sh and cereal intake were the most important risk reduction factors.These fi ndings have been generally confi rmed by Drs.Luchsinger and Morris and others.The reason I did my study was that the Honolulu Heart Study reported that Japanese American men in Hawaii had 2.5 times the risk of AD of native Japanese.African-Americans have about four times the risk of AD of native Nigerians.If genetics were the primary risk factor, those living in the US would have a risk of developing AD very similar to that of individuals living in their ancestral home.The reason this is not the case is that the American diet provides too much food, which is a particular problem for those genetically predisposed to AD.
DRAINAGE OF EXTRAVESICAL AND EXTRA-PERITONEAL SUPPURATIONS OF THE MALE PELVIS.
Authors: EUGENE FULLER
Journal: JAMA (1902)

<h3>ANATOMIC RELATIONS.</h3> The anatomic part to be considered represents the space, or perhaps better, the line of union, bounded externally by the deep pelvic fascia which covers the inner contour of the pelvic cavity and internally by the peritoneum and by the fibrous sheath which envelops in common the bladder, the male sexual apparatus and the upper rectum. This sheath is really formed of deflections from the deep pelvic fascia which project upward from the points where the pelvic viscera make their exits from the pelvic cavity. It is evident, therefore, that the lower limits of this space are sharply defined, while there is really no definition to the upper limits, these latter being simply continuous with the line of union of the peritoneum and the abdominal fascia. In the upper anterior portion of this pelvic space and on the border line between it and the abdominal line of union
When is it justified to stop the pill?
Authors: R. Stone
Journal: BMJ (1980)

SIR,-The study in your last issue by Dr I G Barrison and others (18 October, p 1040) incorporated two false premises: (a) that "heavy drinkers" are likely to reveal them- selves during "routine history taking"; and (b) that a heavy drinking habit is a necessary or sufficient condition for the diagnosis of an alcoholic.
Growth differentiating factor 15 enhances the tumor-initiating and self-renewal potential of multiple myeloma cells
Authors: Toshihiko Tanno, Yiting Lim, Qiuju Wang, Marta Chesi, P. Leif Bergsagel, Geoff Matthews, Ricky W. Johnstone, Nilanjan Ghosh, Ivan Borrello, Carol Ann Huff, William Matsui
Journal: Blood (2013)
Gross Anatomy Associated with Patterns Called Left Posterior Hemiblock
Authors: A. WADE STRICKLAND, LEO G. HORAN, NANCY C. FLOWERS
Journal: Circulation (1972)

From a compilation of 1411 gross dissections of the hearts from patients who had had recent electrocardiograms prior to death, 62 were found to have frontal QRS axes between +90 and +180°. Thirty-eight exhibited an S 1 Q 3 R 3 pattern-the second screening criterion basic to consideration for the label of left posterior hemiblock (LPH). Twenty-two of these also had right ventricular free wall weights in excess of 70 g. Two others exhibited inferior myocardial infarction only. Of the remaining 14, six afforded mild clinical suspicion of increased hemodynamic loading of the right heart but did not have increased right ventricular weights. Four had right bundle-branch block (RBBB), and only one had a prolonged P-R interval. The S 1 Q 3 R 3 pattern with right-axis deviation thus occurred in patients with or without right ventricular hypertrophy and with or without inferior wall myocardial infarction. Right bundle-branch block was a frequent occurrence in the spectrum of right-axis deviation (RAD) whether S 1 Q 3 R 3 was present or not. The scatter of the frequent associates of RAD-inferior myocardial lesions, right ventricular hypertrophy, a clinical history of right ventricular loading diseases, and RBBB—suggests three alternative ways of viewing the S 1 Q 3 R 3 pattern with RAD: (1) LPH is a cause of S 1 Q 3 R 3 with RAD. It is a manifestation of left ventricular myocardial disease, but it may be a result of overt infarction, or may be mimicked by right ventricular disease. (2) LPH is the cause of S 1 Q 3 R 3 with RAD. It is the means by which diverse etiologies produce a distinctive electrocardiographic pattern (including left ventricular myocardial deficits, right ventricular enlargement, or a small group of unknown causes). (3) LPH is an artifact of convenience. Patients with RAD may or may not have S 1 Q 3 R 3 ; they frequently have inferior wall myocardial infarction, right ventricular overload or enlargement, and RBBB.
Preselection of donors to improve the quality of cryoprecipitate
Authors: Peter A. Tomasulo, William Richards, Marilyn Bailey, Mieczyslaw Gajewski, Richard H. Aster, Jack Lazerson
Journal: American Journal of Hematology (1980)

Abstract In theory, the potency of cryoprecipitated antihemophilic factor (cryo) can be increased by utilizing plasma only from donors with high levels of factor VIII procoagulant activity (fVIII c ). Previous reports have suggested that plasma of group O individuals has, on the average, less fVIII c than plasma from individuals of blood groups A, B, and AB. We have investigated the feasibility of increasing the potency of cryo by preselecting plasma for cryo production on the basis of the blood group of the donor. FVIII c levels of fresh plasma, fresh frozen plasma (FFP), and cryo (prepared both by air‐thaw and water‐thaw methods) were assayed. The plasma, FFP, and cryo from group O donors contained only 75% of the fVIII c present in plasma from group A, group B, and group AB donors. Following infusion to patients with hemophilia, in vivo recovery and survival of fVIII c activity from groups A, B, and AB cryo reflected the higher in vitro levels. The mean potency of bags of cryo can be increased, and the cost of hemophilia treatment with cryo can be reduced by excluding group O plasma from the production of cryoprecipitate.
Typhus Fever with Particular Reference to the Serbian Epidemic.
Authors: Richard Pearson Strong, George C. Shattuck, A. W. Sellards, Hans Zinsser, J. Gardner Hopkins
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ruptured Ovarian Follicular Cyst
Authors: P. H. Drake
Journal: BMJ (1964)

Ruptured Ovarian Follicular Cyst SIR,-Simple follicular cysts of the ovary are very common and frequently rupture during examination.This may seem hazardous, but most textbooks are agreed that it does no harm.However, the following case illus- trates an exception to the general rule.A 36-year-cld gravida-5 gave this history.Her periods had been quite ncrrn3l.but she had had seven weeks' amenorrhoea followed by 18 days' continuous but slight bleeding.She was at first thought to have a threatened abortion and had been treated with rest and ethisterone, 25 mg.daily.After 12 days the loss increased and she developed labour-like abdominal pains.The abortion was now considered to be incomplete and ergometrine 0.5 mg.t.d.s.~was given for three days, but as slight bleeding persisted she was transferred to hospital.
The Debt and the Cash Flow of Residents: II. And Now for the Future: The End of HEAL?
Authors: Thomas L. Walden
Journal: JAMA (1990)

<h3>To the Editor.—</h3> The Health Education Assistance Loan (HEAL), an important source of financial assistance for medical students, has been targeted for elimination by its insurer, the federal government. This action, proposed in the 1991 budget because of the 8.2% default rate and the physician surplus, would be disastrous for medical students. More important, the proposed elimination is based solely on financial concerns and ignores the health care needs of the American people. The rising cost of medical education since abolition of per capita payments in 1974 and of the National Health Service Corps in 1981 has forced more students to rely on HEAL. Of the $642.5 million allocated to medical students for scholarships and aid during the 1987-1988 school year, 13% was generated through the HEAL program.<sup>1</sup> The average 1988 graduate from a private medical school had a debt of $48 068. At my school, Georgetown University, where
DNA immunization to prevent autoimmune diabetes
Authors: Bryan Coon, Ling-Ling An, J. Lindsay Whitton, Matthias G. von Herrath
Journal: Journal of Clinical Investigation (1999)

Mice expressing lymphocytic choriomeningitis virus nucleoprotein (LCMV-NP) as a transgene in their β cells develop insulin-dependent diabetes mellitus (IDDM) only after LCMV infection. Inoculation of plasmid DNA encoding the insulin B chain reduced the incidence of IDDM by 50% in this model. The insulin B-chain DNA vaccination was effective through induction of regulatory CD4 lymphocytes that react with the insulin B chain, secrete IL-4, and locally reduce activity of LCMV-NP–autoreactive cytotoxic T lymphocytes in the pancreatic draining lymph node. In contrast, similar vaccination with plasmids expressing the LCMV viral ("self") protein did not prevent IDDM, because no such regulatory cells were induced. Thus, DNA immunization with plasmids expressing self-antigens might constitute a novel and attractive therapeutic approach to prevent autoimmune diseases, if the antigens are carefully preelected for an ability to induce regulatory lymphocytes in vivo.
Haemorrhagic myositis associated with prophylactic heparin use in dermatomyositis
Authors: D M Langguth
Journal: Annals of the Rheumatic Diseases (2004)

An 80 year old man was admitted with a short history of fever, dyspnoea, and productive cough. A chest radiograph disclosed right lower lobe infiltrates, and a diagnosis of community acquired pneumonia was made. However, it was noted that he had profound weakness of the proximal, respiratory, and bulbar muscles together with typical features of dermatomyositis, including periorbital oedema and heliotrope discolouration, nailfold infarcts, and Gottron’s papules. The serum creatine kinase (CK) level was raised at 1850 IU (reference range<300 IU). An electromyogram and muscle biopsy of the left vastus lateralis confirmed inflammatory myositis. There was no excess bleeding at the site. The diagnosis was …
Postmarketing surveillance of the safety of cimetidine: 12 month mortality report.
Authors: D G Colin-Jones, M J Langman, D H Lawson, M P Vessey
Journal: BMJ (1983)

A total of 9928 patients taking cimetidine and 9351 controls were recruited to a postmarketing drug surveillance study in Glasgow, Nottingham, Oxford, and Portsmouth. Takers were identified by the Prescription Pricing Bureau at Nottingham and by dispensing pharmacists at the other three centres. All but 1.2% of the takers and 1.6% of the controls were successfully followed up for one year during which hospital visits and deaths were recorded. Three hundred and seventy five of the cimetidine takers and 198 of the controls are known to have died. Most of the difference in mortality was accounted for by an excess among the takers of deaths from cancers of the oesophagus, stomach, colon, and lung; from neoplasms of the lymphatic and haematopoietic system; and from ischaemic heart disease, chronic liver disease, and accidents and poisonings. So far as can be assessed, however, none of these drug-disease associations represented adverse effects of cimetidine treatment; on the contrary, they resulted from cimetidine being used, knowingly or unknowingly, for treating the symptoms of various diseases or for alleviating adverse effects of other agents such as corticosteroids, non-steroidal anti-inflammatory drugs, and radiotherapy. No evidence of any fatal adverse effects of cimetidine emerged in this study.
Erythrocyte Preservation. VIII. Metabolic Degradation of Nucleosides In Vitro and In Vivo1
Authors: Marion Hennessey, Clement A. Finch, Beverly Wescott Gabrio
Journal: Journal of Clinical Investigation (1957)

adenosine triphosphate; PCA = perchloric acid; ACDI, ACDA, ACDG, = acid-citrate-dextrose, inosine, adeno- sine or guanosine
CD64, a Reliable Biomarker of Bacterial Infection in Intensive Care Units?
Authors: Mikael Roussel, Antoine Gros, Elise Sauvadet, Arnaud Gacouin, Sophie Marqué, Loic Chimot, Sylvain Lavoué, Christophe Camus, Thierry Fest, Yves Le Tulzo
Journal: American Journal of Respiratory and Critical Care Medicine (2012)
Further Sutdies of Agents Isolated from Tissue Cultures Inoculated with Human Leukaemic Bone-marrow
Authors: R. J. Fallon, N. R. Grist, D. R. Inman, R. M. Lemcke, G. Negroni, D. A. Woods
Journal: BMJ (1965)

Amenorrhoea-7efcoateMEDIm Amenorrhoea is rarely caused by organic disease in the hypo- thalamus and the pituitary, but is often associated with certain general disorders, with dietetic errors resulting in either an increase or a loss of weight, and with psychological and environmental changes.Treatment of amenorrhoea depends on its cause, and the determination of this requires full investigation, which should generally include bacteriological examination of the endo- metrium to exclude tuberculosis.The prognosis is good in cases of secondary amenorrhoea, menstruation returning in 6000 of cases irrespective of treatment.
Cardiovascular and Renal Effects of Long-term Antihypertensive Treatment
Authors: Marianne Hartford
Journal: JAMA (1988)

To study whether restoration of a normal circulatory system could be achieved with antihypertensive treatment, 13 hypertensive men with structural cardiovascular changes and 37 normotensive control subjects were investigated by echocardiography, apexcardiography, plethysmography, inulin and p-aminohippurate clearance, and determination of 24-hour urinary excretion of albumin, first at age 49 years and again seven years later. All men were untreated at the first investigation. Immediately thereafter, therapy with the cardioselective β-adrenoceptor blocker metoprolol tartrate was initiated in the hypertensive men. Seven years of antihypertensive treatment resulted in (1) normalization of central and peripheral hemodynamic variables, (2) reversal of left ventricular hypertrophy in proportion to achieved blood pressure control, (3) normalization of systolic wall stress and a well-preserved systolic left ventricular function, (4) normalization of diastolic left ventricular function, and (5) normalization of increased microalbuminuria and a decrease in renal vascular resistance, with no change in glomerular filtration rate compared with control subjects. In conclusion, the findings strongly indicate that regression of cardiovascular structural changes can be achieved with long-term antihypertensive treatment. (<i>JAMA</i>1988;259:2553-2557)
Gene-Engineered Varicella-Zoster Virus–Reactive CD4+ Cytotoxic T Cells Exert Tumor-Specific Effector Function
Authors: Silke Landmeier, Bianca Altvater, Sibylle Pscherer, Bodo R. Eing, Joachim Kuehn, Cliona M. Rooney, Heribert Juergens, Claudia Rossig
Journal: Cancer Research (2007)

Abstract T cells with grafted specificities for surface antigens provide an avenue for rapidly producing immune effector cells with tumor specificity. However, the function of chimeric receptor (chRec) gene-modified T cells is limited by lack of T-cell expansion and persistence. We propose to use varicella zoster virus (VZV)–reactive T cells as host for the chRec because these cells can be expanded both in vitro and in vivo by stimulation of their native receptor during endogenous reexposure to the virus or by administration of VZV vaccine. We obtained human T cells reactive with VZV from the peripheral blood of seropositive donors by stimulation with VZV lysate and evaluated their characteristics after genetic modification with two tumor-specific model chRecs. Cultures dominated by cytolytic CD4+ T cells (VZV-CTL) could be expanded and maintained in vitro. Gene-modified VZV-CTL recognized and lysed tumor targets in a MHC-independent manner while maintaining functional, MHC-restricted interaction with VZV antigen through their native receptor. Thus, chRec-transduced VZV-CTL may provide a source of potent tumor-reactive cells for adoptive immunotherapy of cancer. The availability of a safe and effective VZV vaccine provides the option of repeated in vivo stimulation to maintain high T-cell numbers until the tumor is eliminated. [Cancer Res 2007;67(17):8335–43]
NINDS at 50: An Incomplete History Celebrating the Fiftieth Anniversary of the National Institute of Neurological Disorders and Stroke
Authors: F. R. Freemon
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thromboembolic Disorders And Oral Contraceptives
Authors: Cecil Hougie
Journal: JAMA (1969)

<h3>To the Editor:—</h3> An important point on possible relationships between thromboembolic disorders and oral contraceptive agents which was not sufficiently emphasized by your recent correspondents<sup>1-4</sup>is that the diagnosis of thromboembolic disease is often difficult. In the study of Freiman et al,<sup>5</sup>old or recent thromboemboli were found in 64% (39) of the cases in a series of 61 consecutive adult autopsies. This work shows clearly that only a very small fraction of patients with pulmonary emboli present with clinical manifestations, and while the majority of embolizations are probably of no clinical significance, many of the more severe episodes are overlooked. More recently Morrell and Dunhill<sup>6</sup>reported finding pulmonary emboli in 52% of 263 autopsy cases after methodical examination of one lung from each patient; the other lung was examined in the routine autopsy manner and pulmonary emboli were found in only 12%. In other words, the
The Effects of Nonpharmacological Interventions on Subjective Memory Complaints: A Systematic Review and Meta-Analysis
Authors: B. Metternich, D. Kosch, L. Kriston, M. Härter, M. Hüll
Journal: Psychotherapy and Psychosomatics (2008)

Subjective memory complaints (SMC) in the absence of psychiatric or neurological disorders are common among older adults. Although increasing numbers of individuals are suffering from SMC, research into interventions alleviating SMC is sparse. The present systematic review was conducted in order to present a clearer picture of the quality, quantity and outcomes of SMC intervention research.PubMed and PsychInfo were searched with a comprehensive search string delivering 4,496 hits. Abstracts and - if applicable - full texts of these studies were screened by independent raters according to predefined criteria. Fourteen relevant studies were included in the review. The categories of intervention were: conventional memory training (MT; n = 8), expectancy change (EC: cognitive restructuring, psychoeducation, etc.; n = 5), combined interventions (n = 5), physical training (n = 1), and physical and mental training combined (n = 2). The outcomes were: subjective memory measures, objective memory, depressive symptoms and well-being.EC, followed by combined interventions, was most efficient in influencing subjective memory. MT or physical and mental training combined were not efficient. On objective memory, MT was the only efficient intervention. No effects were found on depressive symptoms and well-being, with low numbers of studies in these comparisons.EC seems to be most efficient in influencing SMC, whereas in objective memory MT is the only effective intervention. Depressive symptoms or well-being do not seem to be influenced significantly by any of the interventions. To date, the number of high-quality publications on SMC interventions is relatively low. More randomized controlled trials including measures of depressive symptoms and well-being are needed.