Early Treatment for Acute Ischemic Stroke
Authors: William G. Barsan, Thomas G. Brott, Charles P. Olinger, John R. Marler
Journal: Annals of Internal Medicine (1989)

Editorials15 September 1989Early Treatment for Acute Ischemic StrokeWilliam G. Barsan, MD, Thomas G. Brott, MD, Charles P. Olinger, MD, John R. Marler, MDWilliam G. Barsan, MD, Thomas G. Brott, MD, Charles P. Olinger, MD, John R. Marler, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-6-449 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEarly treatment for ischemic stroke has been a difficult objective to attain and has been stated to be impractical for several reasons. Stroke patients, who usually have no pain and may not be aware of their deficits, may not seek immediate medical care. In addition, it is impossible to detect all patients with reversible ischemic deficits unless at least 24 hours have passed. Finally, there is no proven treatment to reverse ischemic stroke, whether initiated early or late. For these reasons, early treatment has not been emphasized in studies of acute ischemic stroke in humans.In a collective review (1)...References1. CapildeoHabermanRose RSF. Stroke trials: the facts. In: Rose FC, ed. Advances in Stroke Therapy. New York: Raven Press; 1982. Google Scholar2. GelmersGorterDe Weerdt HKC. A controlled trial of nimodipine in acute ischemic stroke. N Engl J Med. 1988;318:203-7. CrossrefMedlineGoogle Scholar3. HsuFaughtFurlan CRA. Intravenous prostacyclin in acute nonhemorrhagic stroke: A placebo-controlled double-blind trial. Stroke. 1987;18:352-8. CrossrefMedlineGoogle Scholar4. MeyerPiepgrasSundtYanagihara FDTT. Emergency embolectomy for acute occlusion of the middle cerebral artery. J Neurosurg. 1985;62:639-47. CrossrefMedlineGoogle Scholar5. DiazAusmanMehta FJB. Acute cerebral revascularization. J Neurosurg. 1985;63:200-9. CrossrefMedlineGoogle Scholar6. SolisRobersonTaverasMohrPessin OGJJM. Cerebral angiography in acute cerebral infarction. 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OlingerBrottBarsan CTW. Double-blind randomized placebo-controlled study of ancrod as therapy for acute cerebral infarction [Abstract]. Stroke. 1988;19:133. Google Scholar18. TimerdingBarsanHedges BWJ. Stroke patient evaluation in the emergency department before thrombolytic therapy. Am J Emerg Med. 1989;7:11-5. CrossrefMedlineGoogle Scholar19. BrottHaleyLevy TED. Tissue plasminogen activator (tPA) as very early therapy for cerebral infarction. [Abstract]. Stroke. 1988;19:133. Google Scholar20. CwinnPonsMooreMarxHonigmanDinerman AAEJBN. Prehospital advanced trauma life support for critical blunt trauma victims. Ann Emerg Med. 1987;16:399-403. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: William G. Barsan, MD; Thomas G. Brott, MD; Charles P. Olinger, MD; John R. 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They are relevant to human disease.Treatment of Acute StrokeGregory J. del Zoppo, MD, Anthony Furlan, MD, Werner Hacke, MDHigh-dose intravenous naloxone for the treatment of acute ischemic stroke.Treatment for StrokeSaul B. Gilson, MD 15 September 1989Volume 111, Issue 6Page: 449-451KeywordsEmergency medicineIschemic strokeStroke ePublished: 1 December 2008 Issue Published: 15 September 1989 PDF downloadLoading ...