tbuckley/cabot-search huggingface dataset:
Monoclonal gammopathy after low‐grade MALT lymphoma: Evidence for a second neoplasm
Authors: S. Pachmann, B. Anderegg, J. Müller‐Höcker, W. Nathrath, N. Brack, F.J. Tigges, R. Hartenstein, R. Munker
Journal: American Journal of Hematology (2002)

Abstract We report the case of a patient with lymphoma of the salivary gland, at first diagnosed as lymphoma of mucosa‐associated lymphoid tissue (MALT lymphoma) but later found to infiltrate the bone marrow. At diagnosis, the patient had a polyclonal increase of gamma‐globulins. Five years after initial diagnosis, the patient presented with monoclonal gammopathy and infiltration of the bone marrow with neoplastic cells. Initially, the patient had received chemotherapy with different protocols (including etoposide, cyclophosphamide, fludarabin, methotrexate, and vincristine), none of which induced a lasting response. Therapy with rituximab (chimeric anti‐CD20 monoclonal antibody) finally led to partial remission. Eighteen months after rituximab, progressive lymphoma in the abdomen and a monoclonal gammopathy developed. The bone marrow showed infiltration by lymphoplasmacytoid cells (monoclonal expression of the light‐chain type lambda, positive for CD20, heterogeneous expression of CD45). The patient achieved another short clinical response with 4 cycles of the CHOP‐protocol, but soon the lymphoma progressed again. Five years and 8 months after the initial diagnosis, the patient died from septicemia and progressive lymphoma. By polymerase chain reaction (PCR) for the IgH gene it was shown that lymphoma cells were initially oligoclonal in the salivary gland and, later, biclonal in the bone marrow. Sequencing of two bands of apparently same length showed that these manifestations of lymphoma were not identical. Taken together, our data show that the initial low‐grade oligoclonal MALT lymphoma was no longer present and a more aggressive biclonal lymphoma with plasmacytoid differentiation had developed. The new lymphoma was clonally distinct and produced high amounts of monoclonal IgG lambda by immunoelectrophoresis. The relationship of the second lymphoma to the initial MALT lymphoma is discussed. Am. J. Hematol. 70:167–173, 2002. © 2002 Wiley‐Liss, Inc.
CHANGE IN STATIN THERAPY AFTER CCTA IS ASSOCIATED WITH LOWER LDL-CHOLESTEROL WITHOUT CHANGE IN THREE-YEAR PROGNOSIS
Authors: Edward Hulten, Marcio Bittencourt, Avinainder Singh, Daniel O'Leary, Mitalee Patil, Wafa Osmani, Suhny Abbara, Michael Steigner, Khurram Nasir, Quynh Truong, Josh Klein, Jon Hainer, Frank Rybicki, Udo Hoffmann, Marcelo Di Carli, Brian Ghoshhajra, Ron Blankstein
Journal: Journal of the American College of Cardiology (2013)
Balanced view of risks of oral contraceptives
Authors: Walter O Spitzer
Journal: The Lancet (1997)

Available studies on the association between the use of combined oral contraceptives (OCs) and the risk of three serious side effects (myocardial infarction, ischemic and hemorrhagic stroke, and venous thromboembolism) were reviewed at a World Health Organization (WHO) scientific group meeting held in November 1997. The group's findings have been published in the November 28, 1997, issue of "WHO Weekly Epidemiological Record." Of concern to the author of this letter to the editor was the exclusion, with no clear criteria, of many lead investigators from closed sessions. Also notable was the tendency of the panel to downplay controversies about the differences between second- and third-generation OCs in the risk of venous thromboembolism. Moreover, the conclusions on myocardial infarction minimize the likely protective effect of third-generation compared with second-generation OCs. Finally, the summary report does not mention possible bias sources or clarify the lack of clinical and public health significance of odds ratios of 2.0 or less for adverse effects that are extremely rare. In the author's opinion, WHO should have given greater emphasis to the continually improving safety of OCs.
Hypertension
Authors: Irvine H. Page
Journal: JAMA (1976)

IT IS a common characteristic of physicians, artists, and scientists to believe that their own special interests are neglected. No writer ever receives enough praise for his book; no artist is happy with a brief review, and no physician thinks his specialty is given the high place in the pecking order that it is due. In my youth, hypertension was considered a good thing—well, good at least in that it perfused adequate amounts of blood through thickened arteries, especially those in the kidneys. Lowering blood pressure could only lead to ischemia of the kidneys and uremia. Hypertension was believed divisible into two classes: fixed (irreversible) and labile (reversible). Two very convenient beliefs indeed, since no one knew how to lower blood pressure of the "reversible" variety, and "irreversible" meant just that. In the early '30s, there was a general feeling among the newly self-styled cardiologists that hypertension must be more
Pressure on NHS hospitals is "spreading beyond emergency departments," King's Fund warns
Authors: G. Iacobucci
Journal: BMJ (2015)

Capacity problems in NHS hospitals are spreading beyond emergency departments to other key areas of performance, a leading healthcare think tank has warned.

The King’s Fund’s latest monitoring report1 noted increased inpatient and outpatient waiting times, delayed discharges, and cancelled operations in the period from October to December 2014. 

Taken together with the pressures on emergency units this winter,2 the fund’s chief economist, John Appleby, said that the situation was now “critical” as the service grappled with increasing demand and an unprecedented financial squeeze.

The fund’s latest report showed that the proportion of patients waiting for inpatient treatment for longer than 18 weeks rose to 12.5% …
Injury and illness surveillance at local Special Olympic Games.
Authors: D P McCormick, V N Niebuhr, W L Risser
Journal: British Journal of Sports Medicine (1990)

The purposes of this study were to: determine the incidence of injury and illness among Special Olympic athletes at local competitions; assess the relative risk of medical problems among Down's syndrome athletes; and compare the relative risk of sports injury incurred by athletes participating in various Special Olympic events. Health stations were set up at all sports venues and injury/illness surveillance records were kept for all injury/illness encounters during a 3-day competition for 777 Special Olympic athletes. A total of 3.5% of the athletes required injury/illness care during the games. Down's syndrome athletes were 3.2 times as likely to encounter a medical problem. Track and field events provided the least activity time and the most injuries. These data suggest that Special Olympic games at the local level are safe and that planners should prepare to treat more illnesses than injuries at such competitions.
The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway
Authors: Yasuharu Sasaki, Masaaki Suzuki, Hiroyoshi Hidaka
Journal: Pharmacology & Therapeutics (2002)
Concentration-response curves of positive inotropic agents before and after ouabain pretreatment
Authors: L. BROWN, E. ERDMANN
Journal: Cardiovascular Research (1985)

Journal Article Concentration-response curves of positive inotropic agents before and after ouabain pretreatment Get access LINDSAY BROWN, LINDSAY BROWN Search for other works by this author on: Oxford Academic PubMed Google Scholar ERLAND ERDMANN ERLAND ERDMANN **Please address all correspondence and reprint requests to: Prof Dr med Erland Erdmann, Medizinische KIinik I der Universität München, Klinikum Groβhadem, Marchioninistr. 15, D-8000 München 70, Gemany. Telephone: (089) 70 95 30 60. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 19, Issue 5, May 1985, Pages 288–298, https://doi.org/10.1093/cvr/19.5.288 Published: 01 May 1985
Premalignant lesions and hepatocellular carcinoma in a non-cirrhotic alcoholic patient with iron overload and normal transferrin saturation
Authors: Jean Frédéric Blanc, Victor De Ledinghen, Pascale Trimoulet, Brigitte Le Bail, Pierre-Henri Bernard, Jean Saric, Charles Balabaud, Paulette Bioulac-Sage
Journal: Journal of Hepatology (1999)
EXPERIMENTAL GLOMERULONEPHRITIS
Authors: Emil R. Unanue, Frank J. Dixon
Journal: The Journal of Experimental Medicine (1965)

A direct correlation between the amount of kidney-fixing antibody and the degree of associated renal injury was demonstrated for rabbit and duck nephrotoxic antibodies. No evidence for a qualitative difference among nephrotoxic antibodies of a given type was obtained. It appeared that duck nephrotoxic antibody was directed against a wider spectrum of rat renal antigens than was rabbit nephrotoxic antibody. In order to produce immediate proteinuria an amount of rabbit or duck gamma-2 kidney-fixing antibody capable of occupying approximately 45 per cent or more of the capillary filtration surface was needed. For immediate proteinuria an amount of rabbit gamma-2 kidney-fixing antibody capable of reacting with more than one-half of the available antigenic sites was needed. Less than twice that amount of rabbit antibody completely saturated available antigenic sites in the kidney. Virtually all nephrotoxic antibodies in hyperimmune rabbit nephrotoxic sera were of the gamma-2 variety while nephrotoxic antibodies in comparable duck nephrotoxic sera were found in gamma-2 (with 5.8 and 7.4S sedimentation coefficients) and gamma-1M fractions. Gamma-1M duck nephrotoxic antibody was 60 times more potent a nephritogen than gamma-2 duck nephrotoxic antibody on a molecular basis. Mercaptoethanol abolished the nephrotoxicity of gamma-1M duck antibody and reduced that of gamma-2 duck antibodies but had no effect on rabbit gamma-2. In no case did mercaptoethanol treatment have an effect on the kidney-fixing properties of the antibodies involved. After injection of nephrotoxic antibodies there appeared to be a prompt fixation of a majority of the antibody to tissue antigens primarily in the kidney. However, a small amount of potentially kidney-fixing antibody remained in the circulation for a considerable period apparently reflecting a dissociation of less avid antibodies with an equilibrium between fixed and free antibody. The role of this more easily dissociable antibody in the progression of nephrotoxic nephritis is not certain but it is possible that it could play a role in the early progression of the disease.
Hepatitis B virus (HBV) and hepatitis C virus (HCV) infection epidemiology in Moscow region during 1995–1999
Authors: Vassili A. Isakov, Gennadi V. Tsodikov, Igor O. Ivanikov, Alla N. Kaira, Tatiana R. Seliverstova, Yuri K. Shakhovski
Journal: Journal of Hepatology (2001)
Osteomyelitis and Septic Arthritis
Authors: Yhu-Hsiung Lee, Morris D. Kerstein
Journal: New England Journal of Medicine (1971)

SINCE percutaneous subclavian venipuncture was first described in 1952,1 the procedure has been widely used. Despite the simplicity of the technic, numerous complications have been reported.2 3 4 5 6 7 8 9 10 11 12 13 14 15 In the following case osteomyelitis of the clavicle and septic arthritis of the sternoclavicular joint with Pseudomonas aeruginosa were associated with this procedure.Case ReportA 39-year-old woman was admitted to the Boston City Hospital on July 28, 1970, with a ventral hernia that was repaired electively on the 8th hospital day. The postoperative course was uneventful until the 17th day, when the surgical wound dehisced and appeared to be infected. Culture of the . . .
miRNA-mRNA integrative analysis in primary myelofibrosis CD34+ cells: role of miR-155/JARID2 axis in abnormal megakaryopoiesis
Authors: Ruggiero Norfo, Roberta Zini, Valentina Pennucci, Elisa Bianchi, Simona Salati, Paola Guglielmelli, Costanza Bogani, Tiziana Fanelli, Carmela Mannarelli, Vittorio Rosti, Daniela Pietra, Silvia Salmoiraghi, Andrea Bisognin, Samantha Ruberti, Sebastiano Rontauroli, Giorgia Sacchi, Zelia Prudente, Giovanni Barosi, Mario Cazzola, Alessandro Rambaldi, Stefania Bortoluzzi, Sergio Ferrari, Enrico Tagliafico, Alessandro M. Vannucchi, Rossella Manfredini
Journal: Blood (2014)
Draw Your Own Inconclusions
Authors: Solomon Garb
Journal: JAMA (1965)

To the Editor:—  I am delighted that the AMA has plans  an allinconclusive data center ( 194 ; adv p 9, Oct 25, 1965). This is a real breakthrough in the utilization of Parkinson's law by medicine, and I would like to enter my application for the position of consultant on surveys and questionnaires, provided that the salary is not too all-inconclusive.
Histocompatibility (HL-A) Antigens Associated with Systemic Lupus Erythematosus
Authors: F. Carl Grumet, Ann Coukell, Julia G. Bodmer, Walter F. Bodmer, Hugh O. McDevitt
Journal: New England Journal of Medicine (1971)

Systemic lupus erythematosus is a disease characterized by several immunologic abnormalities. We determined the HL-A antigens of 40 patients by a standard lymphocyte cytotoxicity test. Specificity HL-A8 was present in 33 per cent, and W15 (LND) in 40 per cent of the patients, as compared to control population frequencies of 16 per cent (p less than 0.025) and 10 per cent (p less than 0.0005), respectively. Nineteen other HL-A antigens did not differ significantly between patients and the control population, and no unusually frequent phenotypes were observed. The association between histocompatibility loci and susceptibility to certain diseases may be mediated by histocompatibility-linked immune response genes analogous to such associations demonstrated in mice. Other possible mechanisms for this association are that histocompatibility antigens represent specific receptor sites for attachment of a virus and that "cross-tolerance" enables viral antigens to mimic certain histocompatibility antigens.
CD4+CD25+Foxp3+ Regulatory T Cells Promote Th17 Cells In Vitro and Enhance Host Resistance in Mouse Candida albicans Th17 Cell Infection Model
Authors: Pushpa Pandiyan, Heather R. Conti, Lixin Zheng, Alanna C. Peterson, Douglas R. Mathern, Nydiaris Hernández-Santos, Mira Edgerton, Sarah L. Gaffen, Michael J. Lenardo
Journal: Immunity (2011)
Hepatic origin of cholesteryl oleate in coronary artery atherosclerosis in African green monkeys. Enrichment by dietary monounsaturated fat.
Authors: L L Rudel, J Haines, J K Sawyer, R Shah, M S Wilson, T P Carr
Journal: Journal of Clinical Investigation (1997)

Relationships among plasma lipoprotein cholesterol, cholesterol secretion by the isolated, perfused liver, and coronary artery atherosclerosis were examined in African green monkeys fed diets containing cholesterol and 35% of calories as fat enriched in polyunsaturated, monounsaturated, or saturated fatty acids. The livers of animals fed monounsaturated fat had significantly higher cholesteryl ester concentrations (8.5 mg/g wet wt) than the livers of the other diet groups (3.65 and 3.37 mg/g wet wt for saturated and polyunsaturated fat groups, respectively) and this concentration was highly correlated with plasma cholesterol and apoB concentrations in each diet group. Cholesteryl oleate was 58 and 74. 5% of the liver cholesteryl ester in the saturated and monounsaturated fat groups. In each diet group, perfusate cholesteryl ester accumulation rate was highly correlated to liver and plasma cholesterol concentrations, and to plasma LDL cholesteryl ester content. Cholesteryl oleate was 48 and 67% of the cholesteryl esters that accumulated in perfusate in the saturated and monounsaturated fat animals, and this percentage was very highly correlated (r = -0.9) with plasma apoB concentration. Finally, in these two diet groups, liver perfusate cholesteryl ester accumulation rate was well correlated (r >/= 0.8) to coronary artery cholesteryl ester concentration, a measure of the extent of coronary artery atherosclerosis that occurred over the five years of diet induction in these animals. These data define an important role for the liver in the cholesteryl oleate enrichment of the plasma lipoproteins in the saturated and monounsaturated fat groups, and demonstrate strong relationships among hepatic cholesteryl ester concentration, cholesteryl ester secretion, and LDL particle cholesteryl ester content. The high correlation between liver cholesteryl ester secretion and coronary artery atherosclerosis provides the first direct demonstration of the high degree of importance of hepatic cholesteryl ester secretion in the development of this disease process. The remarkable degree of enrichment of cholesteryl oleate in plasma cholesteryl esters of the monounsaturated fat group may account for the relatively high amount of coronary artery atherosclerosis in this group.
Bone marrow remission status predicts leukemia contamination in ovarian biopsies collected for fertility preservation
Authors: K Jahnukainen, H Tinkanen, A Wikström, L Dunkel, U M Saarinen-Pihkala, S Mäkinen, B Asadi Azarbaijani, I C Oskam, K Vettenranta, T Laine, V Kairisto, V Juvonen
Journal: Leukemia (2012)
An Unusual Adrenal Metastasis Secondary to Hürthle Cell Carcinoma of the Thyroid
Authors: PIERGIUSEPPE ORSOLON, BRUNO BAGNI, ONELIO GEATTI, UGO PAOLO GUERRA
Journal: Clinical Nuclear Medicine (1996)

A 66-year-old woman with Hürthle cell thyroid carcinoma associated with a right adrenal gland metastasis suspected on a postradioiodine therapy scan, is reported. Histology specimens confirmed the suspicion. Adrenal metastases have never been reported previouly in this kind of tumor. On radionuclide imaging, there was marked I-131 uptake in the tumor remnant and its metastases, and the tumor spread through both lymphatic and hematogenous routes, as shown by lymph node, bone, and lung metastases.
Legionnaires' disease in UK baby triggers warning over some home birth pools
Authors: J. Wise
Journal: BMJ (2014)

Public Health England has issued a warning about the type of home birthing pool that is filled in advance of labour, after a case of legionnaires’ disease occurred in a baby.

The baby has received intensive care treatment in hospital, and Legionella pneumophila was isolated in samples from the birthing pool. This was the first reported case of legionnaires’ disease linked to a birthing pool in England, although two cases were reported internationally in the late 1990s.

Public Health England’s patient safety alert advised against the use of pools that arrive around two weeks before the expected delivery date, filled immediately, and maintained at a constant temperature via a pump …
Abstract 174: Keratin 8 and 18 knockdown increases cisplatin-induced apoptosis and invasive potential through claudin1/PI3K/NFkB up-regulation in epithelial carcinoma cells
Authors: Anne-Marie Fortier, Monique Cadrin, Éric Asselin
Journal: Cancer Research (2012)

Abstract Keratins are epithelial-specific intermediate filament (IF) proteins, which are expressed in a tissue-specific manner. As part of the cytoskeleton, keratins are important for the mechanical stability and integrity of epithelial cells and tissues. Moreover, a number of keratins are involved in intracellular signalling pathways which regulate response to injuries and non-mechanical stresses, cell growth, cell death and cancer progression. Keratins 8 and 18 (K8/18) are typically co-expressed as the primary keratin pair in simple epithelial cells and their expression are maintained during malignant transformation, hence their use as diagnostic marker in tumor pathology. However, in recent years different studies have shown that IF should not be considered only as markers proteins but also as regulators of cancer cell signaling and that they might play an active role in malignant transformation. In the present study, we addressed the question as to whether K8/18 expression affects tumor fate and behaviour. Our results show that K8/18 stable knockdown using shRNA increases cisplatin sensitivity in three different epithelial cancer cell lines. Indeed, western blot analysis of caspases activation and flow cytometry analysis of AnnexinV/PI staining show that K8/18 knockdown sensitizes cells to cisplatin-induce apoptosis. Increased FasL expression and FasR membrane targeting suggest that apoptosis is enhanced via the death receptor pathway. Moreover, using in vitro wound healing and transwell invasion assays, we observed that K8/18-knockdowned cancer cells display an increased cellular motility and invasion. Interestingly, we observed that these cells present higher PIP3 levels in the plasma membrane as determined by both fluorescence microscopy and flow cytometry analysis. Consequently, the K8/18-shRNA clones show PI3K/Akt/PKC/NFkB pathways hyperactivation and increased MMP-9 expression. Furthermore, these processes are shown to be partially regulated by the tight junction's protein claudin-1, which is highly increased in K8/18-shRNA clones. To our knowledge, these results represent the first indication that K8/18 can influence the phenotype of epithelial cancer cells. Knockdown of K8/18 increases cisplatin sensitivity and invasive potential of epithelial cancer cell lines through the regulation of different cell signaling pathways, involving claudin-1 dependent PI3K activation and NFkB transcription activity. These results support the hypothesis that modulation of K8/18 expression plays an active role in cancer progression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 174. doi:1538-7445.AM2012-174
Twelve- or 24-Hour Oxygen Therapy: Why a Clinical Trial?
Authors: Claude Lenfant
Journal: JAMA (1980)

The question posed at the Sugarloaf Conference is significant, and finding an answer important, because of the high prevalence of COPD and the magnitude of the public health problem it represents. It is estimated that 8 to 9 million people in the United States have COPD, and for about 1 million of these, activity is limited. Obviously, with such numbers, personal suffering and societal losses are considerable. Present knowledge does not provide a basis for effective prevention of the disease or for a cure, once it is established. In many instances the lingering course ends in death. Today COPD ranks sixth among the leading causes of death in the United States, having reached 44,000 deaths in 1976, an increase of 44% over the number in 1968.  The progressive hypoxia that is characteristic of COPD is the major cause of morbidity and can lead to cor pulmonale, a complication of hypoxia
Does delta infection play a part in the pathogenesis of hepatitis B virus related hepatocellular carcinoma?
Authors: R. Esposito, P. Crocchiolo, F. Caredda, R. Bergamaschi, J. C Emmanuel
Journal: BMJ (1984)

intervention trial study and combining the populations, we find that the frequency of lung cancer in the lighter smoking intervention groups was 56/7142 (0 78% ), and in the heavier smoking "normal care" groups was 53/7169 (0 74%/ ).The small advantage enjoyed by the heavier smokers is, of course, statistically non- significant.Nevertheless, these two randomised trials controlled for the bias of self selection.Although the numbers are too small to adjudicate between causal, constitutional, and combined hypotheses of the association between smoking and lung cancer, they are large enough to show how cautious we need to be when interpreting studies of self selected groups.
Ruptured Achilles tendon--preliminary results of a new treatment.
Authors: R Cetti
Journal: British Journal of Sports Medicine (1988)

The preliminary results of a new treatment of ruptured Achilles tendons are presented. The new treatment consists of a new tendon suture and a new post-operative cast in which it is possible to make non-weight bearing movements of the ankle immediately after the operation. This makes it possible to walk the day after the operation, causes very little discomfort during the time in a cast, gives a quick return to normal mobility with normal plantar flexion strength and makes it possible to resume sport at the same level as before the injury.