tbuckley/cabot-search huggingface dataset:
Transjugular intrahepatic portosystemic shunt in hepatorenal syndrome: Effects on renal function and vasoactive systems
Authors: Mónica Guevara, Pere Ginès, Juan Carlos Bandi, Rosa Gilabert, Pau Sort, Wladimiro Jiménez, Juan Carlos Garcia-Pagán, Jaume Bosch, Vicente Arroyo, Juan Rodés
Journal: Hepatology (1998)

Little information exists on the effects of transjugular intrahepatic portosystemic shunts (TIPS) in the management of cirrhotic patients with hepatorenal syndrome (HRS). The current study was aimed to prospectively evaluate the effects of TIPS on renal function and vasoactive systems in patients with type I HRS. Glomerular filtration rate (GFR) (inulin clearance), renal plasma flow (RPF) (para-aminohippurate clearance), plasma renin activity (PRA), aldosterone (ALDO), norepinephrine (NE), and endothelin (ET) were determined in baseline conditions and at different time intervals after TIPS in 7 patients with type I HRS. TIPS induced a marked reduction of portal pressure gradient (PPG) (20 ± 1 to 10 ± 1 mm Hg; P &lt; .05). Renal function improved in 6 of the 7 patients. Serum creatinine and blood urea nitrogen (BUN) decreased from 5 ± 0.8 and 109 ± 7 to 1.8 ± 0.4 mg/dL and 56 ± 11 mg/dL, respectively ( P &lt; .05 for both), and GFR and RPF increased from 9 ± 4 and 103 ± 33 to 27 ± 7 mL/min and 233 ± 40 mL/min, respectively ( P &lt; .05 for both), 30 days after TIPS. These beneficial effects on renal function were associated with a significant ( P &lt; .05) reduction of PRA (18 ± 5 to 3 ± 1 ng/mL · h), ALDO (279 ± 58 to 99 ± 56 ng/dL), and NE (1,257 ± 187 to 612 ± 197 pg/mL). ET did not change significantly (28 ± 8 to 27 ± 11 pg/mL). Mean survival was 4.7 ± 2 months (0.3-17 months). Three patients remained alive more than 3 months after TIPS insertion. In conclusion, TIPS improves renal function and reduces the activity of the renin-angiotensin and sympathetic nervous systems in cirrhotic patients with type I HRS. Nevertheless, the efficacy of TIPS in the management of these patients should be confirmed in controlled investigations.
Clinical features and treatment outcome of nasal-type NK/T-cell lymphoma of Waldeyer ring
Authors: Ye-Xiong Li, Hui Fang, Qing-Feng Liu, Jiade Lu, Shu-Nan Qi, Hua Wang, Jing Jin, Wei-Hu Wang, Yue-Ping Liu, Yong-Wen Song, Shu-Lian Wang, Xin-Fan Liu, Xiao-Li Feng, Zi-Hao Yu
Journal: Blood (2008)
Expression and hypoxic regulation of angiopoietins in human astrocytomas
Authors: Hao Ding, Luba Roncari, Xiaoli Wu, Nelson Lau, Patrick Shannon, Andras Nagy, Abhijit Guha
Journal: Neuro-Oncology (2001)

Vascular endothelial growth factor (VEGF) is a major inducer of tumor angiogenesis and edema in human astrocytomas by its interaction with cognate endothelial-specific receptors (VEGFR1/R2). Tie1 and Tie2/Tek are more recently identified endothelial-specific receptors, with angiopoietins being ligands for the latter. These angiogenic factors and receptors are crucial for the maturation of the vascular system, but their role in tumor angiogenesis, particularly in astrocytomas, is unknown. In this study, we demonstrate that the angiopoietin family member Ang1 is expressed by some of the astrocytoma cell lines. In contrast to VEGF, Ang1 is down regulated by hypoxia. Ang2 was not overexpressed. Expression profiles of low-grade astrocytoma specimens were similar to those of normal brain, with low levels of Ang1, Ang2, and VEGF expression. Glioblastoma multiforme expressed higher levels of Ang1, but not to the same degree as pseudopalisading astrocytoma cells around necrotic and hypoxic zones expressed VEGF, as shown in previous studies. Ang2 expression in the highly proliferative tumor vascular endothelium was also increased, as was phosphorylated Tie2/Tek. The expression profile of these angiogenic factors and their endothelial cell receptors in human glioblastomas multiforme was similar to that in a transgenic mouse model of glioblastoma multiforme. These data suggest that both VEGF and angiopoietins are involved in regulating tumor angiogenesis in human astrocytomas.
Transforming growth factor‐beta 1 pathways in inflammatory airway diseases
Authors: Y. Yang, N. Zhang, F. Lan, K. Van Crombruggen, L. Fang, G. Hu, S. Hong, C. Bachert
Journal: Allergy (2014)

Abstract Transforming growth factor‐beta 1 ( TGF ‐β1) has been reported being involved in the remodeling and immunosuppression processes of inflammatory airway diseases; understanding the regulation of TGF ‐β1 is therefore a key to unravel the pathomechanisms of these diseases. This review briefly summarizes the current knowledge on the influencing factors for driving TGF ‐β1 and its regulatory pathways in inflammatory airway diseases and discusses possible therapeutic approaches to TGF ‐β1 control. The factors include smoking and oxidative stress, prostaglandins ( PG s), leukotrienes ( LT s), bradykinin ( BK ), and micro RNA s (miRs). Based on the summary, new innovative treatment strategies may be developed for inflammatory airway diseases with an impaired expression of TGF ‐β1.
Impact of Disease Duration on Cardiovascular and Pupillary Autonomic Nervous Function in IDDM and NIDDM Patients
Authors: Rainer H Straub, Bettina Zietz, Klaus Dieter Palitzsch, Jürgen Schölmerich
Journal: Diabetes Care (1996)

To determine the age-independent impact of disease duration on autonomic nervous function in diabetic patients and to compare it with other disease-related complications.Of the patients with diabetes, 166 (66 IDDM, 100 NIDDM) were investigated using standardized cardiovascular and pupillary test procedures, which provide 10 age-independent percentile values for each patient. Sensorimotor neuropathy was assessed using a standardized clinical examination, retinopathy by fundoscopy, and nephropathy using daily urinary protein excretion and creatinine clearance.The duration of the disease did not correlate with the results of any one of six standard cardiovascular tests (P > 0.15). Pupillary parameters showed a weak negative correlation with disease duration (P < 0.04). Prevalence of cardiovascular autonomic dysfunction was not different in five different subgroups subdivided according to disease duration (0-6, 7-12, 13-18, 19-24, and > or = 25 years), whereas prevalence of pupillary dysfunction changed significantly with disease duration (P = 0.016). In contrast, the prevalence of sensorimotor neuropathy (P = 0.006), retinopathy (P < 0.001), and proteinuria (P = 0.010) was significantly higher in patients with long-standing disease. Disease duration was not significantly different in patients without overall cardiovascular dysfunction, as compared with patients with dysfunction (15.6 +/- 1.0 vs. 16.5 +/- 1.5 years, P = 0.626). This was also found when considering overall pupillary dysfunction (14.5 +/- 1.4 vs. 17.2 +/- 1.0 years, P = 0.125).Disease duration was not correlated with cardiovascular autonomic nervous function, whereas a correlation was observed with pupillary autonomic nervous function, sensorimotor neuropathy, retinopathy, and proteinuria. This may indicate that cardiovascular autonomic nervous function does not markedly change during the course of the disease. The question arises whether cardiovascular autonomic neuropathy may be more a functional abnormality than a structural lesion of the autonomic nervous system, which may be already present at the beginning, or even before, the manifestation of diabetes.
KINETICS OF INTEGRILIN LIMITED BY OBESITY (KILO): A MULTI-CENTER RANDOMIZED CLINICAL TRIAL
Authors: John P. Vavalle, Susanna Stevens, Nancy Hassinger, Mauricio G. Cohen, Anita Arnold, David E. Kandzari, Frank V. Aguirre, Daniel D. Gretler, John H. Alexander
Journal: Journal of the American College of Cardiology (2011)
Abstract B78: Osteopontin-c splicing isoform is a key molecule in ovarian cancer progression
Authors: Tatiana M. Tilli, Kivvi D. Mello, Vanessa Franco, Bruno Robbs, João Luiz Wanderley, Fabrício Rass, João P B Viola, Georg Weber, Vincent Castronovo, Akeila Bellahcène, Etel R P Gimba, Etel Gimba
Journal: Clinical Cancer Research (2013)

Abstract Introduction: Osteopontin (OPN) is a glyphosphoprotein overexpressed in ovarian carcinoma (OC) and is involved in tumorigenesis and metastasis. Alternative splicing of OPN primary transcript generates 3 isoforms, named as OPNa, OPNb, and OPNc. Objective: This study aimed to characterize the expression profile and functional role of each OPN splicing isoform (OPN-SI) in OC. Methodology: The expression patterns of OPN-SI and a series of genes involved in key cancer pathways were analyzed by real-time PCR. In vitro and in vivo functional assays were performed using the ovarian cancer cell line OvCar-3, stably overexpressing the three OPN-SI and conditoned medium secreted by these cells. Results: OPNc, but not OPNa and OPNb, was specifically expressed on OC samples. OPNc splice variant significantly activated OvCar-3 cell proliferation, migration, invasion and anchorage independent cells growth, besides inducing tumor formation in nude mice. We also found that these features are mainly mediated by PI3K/Akt signaling pathway. By using a real time PCR Cancer Gene Array, we found that OvCar-3 OPNc-overexpressing cells are also able to modulate the expression of 34 genes involved in key cancer pathways. Notably, tumors formed by OPNc-overexpressing cells present high expression levels of typical angiogenic markers, such as VEGF-A, VEGFR-2 and CD34. Based on these data, we also investigated the molecular mechanisms by which OPNc stimulates angiogenic processes. Our data showed that OPNc overexpression activates VEGF-A expression and secretion, besides upregulating the expression of c-Fos, c-Jun and phospho-c-Jun. OPNc role on activating the phosphorylation of c-Jun is mediated by the integrin receptor (αvβ3), in an RGD-dependent manner. In addition, OPNc-conditioned medium is able to induce HUVEC endothelial cell proliferation, migration and adhesion. Conclusion: In summary, our data demonstrate that OPNc is able to activate sereral aspects of OC progression, including angiogenesis, mainly by the PI3K/Akt pathway, indicating that this splice variant could be a putative target for further studies aiming to investigate this molecule for new therapeutic approaches for OC. Citation Format: Tatiana M. Tilli, Kivvi D. Mello, Vanessa Franco, Bruno Robbs, João Luiz Wanderley, Fabrício Rass, João P B Viola, Georg Weber, Vincent Castronovo, Akeila Bellahcène, Etel R P Gimba, Etel Gimba. Osteopontin-c splicing isoform is a key molecule in ovarian cancer progression. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: From Concept to Clinic; Sep 18-21, 2013; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2013;19(19 Suppl):Abstract nr B78.
Reversible sterilization in the female.
Authors: A L Deacon
Journal: BMJ (1971)

Diathermy sterilizations may be more readily reversed if the tubal mucosa are not damaged by inflammation.  Tubal ligation should be performed near the juncture of the isthmus with the ampulla and opposite an avascular window in the broad ligament.  Then the tube ends are buried under separated layers of the broad ligament.
Measles virus spread initiated at international mass gatherings in Europe, 2011
Authors: S Santibanez, K Prosenc, D Lohr, G Pfaff, O Jordan Markocic, A Mankertz
Journal: Eurosurveillance (2014)

Three parallel transmission chains of measles virus (MV) variant ‘D8-Villupuram’ (D8-V) originated from two coinciding international mass gathering (MG) events in Rimini, Italy, in June 2011. MV D8-V was independently introduced into Germany by two unvaccinated persons, and into Slovenia by one unvaccinated person who had attended these events. Secondary spread of D8-V was restricted to two generations of transmission in Slovenia as well as in Germany where the virus was further disseminated at another MG. Serological and epidemiological investigation of the D8-V-associated German and Slovenian cases revealed different antibody responses and age distributions. Primary infected young persons between 11 and 27 years-old were affected in Germany, whereas the group of Slovenian cases comprised adults aged from 28 to 47 years and a high proportion (9/14; 64%) of patients with secondary vaccine failure (SVF). Our study demonstrates that monitoring of MV transmission chains in an international context and adequate serological investigation of cases with remote vaccination can contribute to identify susceptibility gaps.
Abstract 3152: Molecular networks regulated by tumor suppressive <i>microRNA-1</i> and <i>microRNA-133a</i> in head and neck squamous cell carcinoma
Authors: Nijiro Nohata, Toyoyuki Hanazawa, Takashi Kinoshita, Naoko Kikkawa, Miki Fuse, Takeshi Chiyomaru, Hirofumi Yoshino, Hideki Enokida, Masayuki Nakagawa, Yoshitaka Okamoto, Naohiko Seki
Journal: Cancer Research (2012)

Abstract (Background) Head and neck squamous cell carcinomas (HNSCC) represent 6% of all cancers. Despite of considerable advances in surgery, radiotherapy and chemotherapy, the overall 5-year survival rate for patients is less than 40% in advanced stage. The understanding of the new molecular networks of HNSCC oncogenesis by recent genome analysis would be helpful in improving diagnosis and therapy of the disease. Our expression signatures of human cancer including HNSCC revealed that the expression of microRNA-1 (miR-1) and microRNA-133a (miR-133a) were significantly reduced in cancer cells. In human genome, miR-1 and miR-133a located same chromosomal regions (miR-1-2 and miR-133a-1 on 18q11.2, and miR-1-1 and miR-133a-2 on 20q13.33) called cluster. Previously, our group reported that miR-1 and miR-133a function as tumor suppressors in several types of cancers including HNSCC. In this study, we identify the novel molecular networks regulated by miR-1 and miR-133a commonly in HNSCC. (Methods) Genome-wide gene expression analysis was performed to identify the molecular networks of miR-1 and miR-133a by microarray technique. A luciferase reporter assay was used to identify the actual binding site between miR-1 and miR-133a and these candidate target genes. Cell proliferation, migration and invasion assays were performed to investigate the functional significance of target genes in HNSCC cell lines. (Results) Genome-wide molecular targets search and luciferase reporter assay showed that transgelin-2 (TAGLN2), prothymosin-alpha (PTMA) and purine nucleoside phosphorylase (PNP) were directly regulated by miR-1 and miR-133a commonly. Silencing of these genes studies demonstrated significant inhibition of cell proliferation, migration and invasion in HNSCC cells. (Conclusions) TAGLN2, PTMA and PNP were directly regulated by tumor suppressive miR-1 and miR-133a commonly. These genes may function as oncogenes contributed to cell proliferation, migration and invasion in HNSCC. Tumor suppressive miR-1 and miR-133a and target oncogenes may provide new insights into the mechanisms in cancer. Our findings have therapeutic implications and may be exploited for future HNSCC treatments. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3152. doi:1538-7445.AM2012-3152
Collapse after intravenous injection of hashish.
Authors: A. H. Henderson, D. J. Pugsley
Journal: BMJ (1968)

Aplasia of the bone marrow was seen in two-thirds of the patients.It was preceded by a rapidly developing pancyto- penia.The bone marrow may show large cells similar to lymphoblasts soon after rubidomycin is given.These cells may persist throughout the aplastic phase.Their presence should not be taken as an indication that more rubidomycin is necessary but rather that the phase of aplasia is imminent or that remission is beginning.Other toxic effects included alopecia and pruritus.No neurotoxicity or renal or liver damage has been seen.It is important not to start maintenance therapy too soon after remission has been achieved.One of the patients (Case 9)
Reflux Esophagitis: Effect of Oral Bethanechol on Symptoms and Endoscopic Findings
Authors: KRISHAN D. THANIK
Journal: Annals of Internal Medicine (1980)

We ascertained the effectiveness of oral bethanechol on symptoms and endoscopic evaluation of reflux esophagitis in a double-blind controlled study. Forty-four patients were treated with either 25-mg bethanechol tablets or placebo, each given four times daily for 4 weeks, in addition to conventional medical therapy. Both therapies significantly decreased symptoms as well as endoscopic lesions; however, endoscopic improvement was significantly better in the bethanechol-treated group. Bethanechol therapy resulted in complete endoscopic healing in 10 of 22 cases, whereas only three of 22 patients in the control group had such healing. No worsening of endoscopic lesions was seen in either group. Our study indicates that bethanechol is an effective drug offering advantages over conventional antacid therapy in the treatment of reflux esophagitis.
Vasopressin Receptor Antagonists
Authors: Gary S. Francis, W. H. Wilson Tang
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
GENETIC AND VIRAL GENOME ANALYSIS OF CHILDHOOD CARDIOMYOPATHY: THE PCMR/PCSR EXPERIENCE
Authors: Jeffrey A. Towbin, Lynn Sleeper, John L. Jefferies, Steven Colan, Steven A. Webber, Charles E. Canter, Daphne T. Hsu, Stephanie M. Ware, James D. Wilkinson, E. John Orav, Steven E. Lipshultz
Journal: Journal of the American College of Cardiology (2010)
Intestinal Parasitosis Among Hospital Employees
Authors: Joseph Ballinger
Journal: JAMA (1962)

NUMEROUS REPORTS exist of the incidence of intestinal parasitosis, especially amebiasis, among various segments of the civilian population. As a result of extensive traveling on the part of Americans and immigration of large population groups from the West Indies, the problem of parasitosis has taken on new significance. Much of the hospital personnel in the Greater New York area is made up of people who have recently migrated from the Southeastern states of this country and from the Caribbean countries where the incidence of intestinal parasitosis is reportedly high. We undertook a study and initiated treatment of intestinal parasitosis among our hospital employees because these people represented a reservoir of disease which could prove a hazard to the community in which they worked and lived. A screening program was initiated on Sept. 1, 1960, in order to determine the incidence of parasites among our hospital employees. The employee population was
The Comparative Pathology of the Tumors of Bone
Authors: David C. Dahlin
Journal: JAMA (1972)

<b>Tumors of Bone and Cartilage,</b>by Harlan J. Spjut et al (<i>Atlas of Tumor Pathology</i>, series 2, fasc 5), 454 pp, 484 illus, paper, $9.85, Washington, DC: Armed Forces Institute of Pathology, 1971. <i>The Comparative Pathology of the Tumors of Bone</i>accomplishes its primary purpose of supplying a compilation of the bone tumors that affect animals, together with a large bibliography. The tumors are related in sequence to comparable or identical tumors in man. The author's information for the latter derives from his own extensive experience in almost two decades of work with some 1,750 cases of tumor or tumor-like diseases, or conditions in which a differential diagnosis of bone tumor came up for consideration in the Bone Tumor Registry at the University of Oregon. The information from this source was augmented by data from several large previously published series. He indicates a hope that the combined information on tumors
Hyposplenism, adult coeliac disease, and autoimmunity.
Authors: A W Bullen, R Hall, G Gowland, S Rajah, M S Losowsky
Journal: Gut (1981)

Functional hyposplenism is associated with a variety of disorders including coeliac disease. The aims of this study were to estimate the need for a small intestinal biopsy in the investigation of hyposplenism, and to assess the relationship of autoimmunity to hyposplenism and coeliac disease. During one year, the features of hyposplenism were found in blood films of 27 patients who had not had a splenectomy. Ten patients were already known to have coeliac disease. Intestinal biopsy was performed in another 13 patients; coeliac disease was diagnosed in six. Of the 23 patients biopsied, coeliac disease was present in 16 (70%). Autoantibodies were detected in significantly more patients with hyposplenism than in healthy controls (P less than 0.05), and in significantly more coeliacs with hyposplenism than coeliacs with normal blood films (P less than 0.01). The increased incidence of autoantibodies in coeliacs with hyposplenism compared with other coeliacs was not associated with a difference in the incidence of HLA-B8. Small bowel biopsy should be carried out in the investigation of unexplained hyposplenism. There may be a link between hyposplenism and the autoimmune manifestations of coeliac disease.
COMBINED SCLEROSIS OF LICHTHEIM-PUTNAM-DANA TYPE ACCOMPANYING PERNICIOUS ANEMIA.
Authors: MARK A. BROWN
Journal: JAMA (1901)

<h3>ABSTRACT OF CASE BY DR. BROWN.</h3> I was first called to see the patient early in July, 1899. He had been in failing health, with varying periods of improvement for between three and four years. To about a year previous to my first seeing him, however, he dates his illness, but was able to be about attending to business until February. The principal point noticeable at first glance was the marked emaciation, and the peculiar color to the entire body; not the blood-cancerous cachexia, nor the anemia of Bright's disease, nor the bloodlessness of the tuberculous, but a brown-yellow color which I have never typically seen save in pernicious anemia. To rule out any other cause, however, a careful physical examination was made. The heart, aside from a soft basal systolic murmur, probably anemic in character, was normal, nor could anything wrong be detected in the lungs. The liver and
Surgical Removal of Liver Flukes from the Common Bile Duct
Authors: Richard C. Clay
Journal: JAMA (1961)

INFESTATION of the human biliary passages with<i>Fasciola hepatica</i>is an uncommon occurrence, especially in the United States, despite the rather wide distribution of this fluke in the animal population. Surgical removal of the adult parasites from the bile ducts is a distinct rarity and seems not to have occurred in this country. But there is a large and growing series of reports of<b>F. hepatica</b>infestation in Central and South America and in Cuba, where a third of reported cases are said to occur. Increasing international travel and the recent influx of Cuban refugees into our country, especially into Florida, would seem to make appropriate the present report of the surgical extraction of flukes from the common bile duct. <i>F. hepatica</i>, it will be recalled, dwells normally in its adult form in the bile passages of sheep and other herbivores, and contaminates their feces with its eggs. These