Danger of Polymxyin B Inhalation
Authors: GERALD MARSCHKE
Journal: Annals of Internal Medicine (1971)

Letters and Comments1 February 1971Danger of Polymxyin B InhalationGERALD MARSCHKE, M.D., ARTHUR SARAUW, M.D.GERALD MARSCHKE, M.D.Search for more papers by this author, ARTHUR SARAUW, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-2-296_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Pseudomonas infection in the chronic pulmonary patient is difficult to treat. Attempting to concentrate the antibiotic at the infection site, we have given polymyxin B sulfate by aerosol, with little therapeutic success. Moreover, two patients developed respiratory distress and are the basis of this report.Patient L.M., a 51-year-old woman with bronchiectasis, entered the hospital 16 Februarv 1965 because of cough, breathlessness, and purulent sputum. Despite treatment with several antibiotics, including injected polymyxin B,Pseudomonas aeruginosapersisted in her sputum. Inhalation therapy, consisting of isoproterenol solution administered with a De Vilbiss nebulizer and an air compressor, was...References1. LINDESMITHBAINESBIGELOW LRD: Reversible respiratory paralysis associated with polymyxin therapy. Ann Intern Med 68:318-327, 1968 LinkGoogle Scholar2. SHELDONLOVELLMATHEWS HRK: A Manual of Clinical Allergy. Philadelphia, W. B. Saunders Co., 1970, p. 1 Google Scholar3. , Tuckahoe, N.Y.: Personal communication Google Scholar4. BEALL G: Urticaria, a review of laboratory and clinical observations. Medicine (Balt) 43:131-151,1964 MedlineGoogle Scholar5. AVIADO D: Physiology and Pharmacology, vol. 1 of The Lung Circulation. Oxford, Pergamon Press Inc., 1965, pp. 256-258 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Respiratory Diseases City of Hope National Medical Center Duarte, Calif. 91010 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClinical Analysis of Drug Allergies to Detect Causative Drugs and Determine Other Aspects of Their Pathogenic MechanismsLipopolysaccharide-binding and neutralizing activities of surfactin C in experimental models of septic shockAerosolised Antibacterials for the Prevention and Treatment of Hospital-Acquired PneumoniaAerosolized Antimicrobial Therapy in Acutely Ill PatientsPolymyxin B Sulfate and Colistin: Old Antibiotics for Emerging Multiresistant Gram-Negative BacteriaAerosolized Treatment of Acute Pulmonary InfectionsLocal Treatment of Respiratory Infections with AntibioticsOther AntibioticsA Review of the Therapeutic Efficacy of Aerosolized and Endotracheally Instilled AntibioticsBronchial reactivity to inhaled polymyxin B in subjects with asthma and chronic obstructive bronchitisBronchiektasie: KlinikInhalation of polymyxin B as a bronchial provocation methodPolymyxin B Reactions, IgE Antibody, and T-Cell Deficiency Immunochemical Studies in a Patient after Bone Marrow TransplantationJAMES D. LAKIN, Ph.D., M.D., DOUGLAS M. STRONG, Ph.D., KENNETH W. SELL, M.D., Ph.D. 1 February 1971Volume 74, Issue 2Page: 296-297KeywordsAntibioticsDyspneaInhalationIsoproterenolPolymyxinsPseudomonas aeruginosaPseudomonas infectionsPulmonary diseasesSputumSulfates Issue Published: 1 February 1971 PDF downloadLoading ...