tbuckley/cabot-search huggingface dataset:
Amyloidosis in Rheumatoid Arthritis treated with Hormones
Authors: D. L. Gardner
Journal: Annals of the Rheumatic Diseases (1962)

Experimental evidence suggests thattreatment with cortisone orACTHincreases therate ofaccumulation oftissue amyloid. ThusTeilum (1952) has shownthatmicepreviously treated withcasein in doses insufficient tocause amyloidosis accumulate amyloid quickly inthespleen after asmall number ofinjections ofcortisone. Latvalahti (1953) has confirmed this observation andhasshownthat mice given either cortisone orACTHdevelop amyloidosis muchmorefrequently whengiven caseinate than micegivencaseinate alone. Similar studies have beenmadebyPerasalo (1954). Widespread amyloidosis ofsecondary distribution isnowrecognized withconsiderable frequency in rheumatoid arthritis (Missen andTaylor, 1956; Cruickshank, 1957). Forsometimeithasseemed possible thattheincidence ofamyloidosis inthis disease mayberising astheresult ofthewidespread therapeutic useofcortisone andother steroids and ofACTH. Thealternative possibility, thatan apparent increase intheincidence ofamyloidosis mayhaveresulted fromcontemporary interest inthe pathological characteristics ofrheumatoid arthritis, hasreceived less attention. Morethan10years haveelapsed since theintroduction ofcortisone therapy. Itappears reasonable toexamine theavailable records ofcases ofrheumatoidarthritis whichhavecometonecropsy inthis centre inanattempt toanswer thequestion posedbytheprovocative experimental evidence.
Dutch GP on murder charge over euthanasia claim
Authors: T. Sheldon
Journal: BMJ (1996)

A Dutch general practitioner is being held in police custody on a murder charge after it was alleged that he failed to meet the Netherlands' comprehensive guidelines on euthanasia. The doctor has been held since 19 April while investigations take place.

An application by his lawyer for his release on the grounds that he is fully cooperating with the police investigation has been rejected. It is extremely rare for doctors to be held in custody in Dutch …
Entoptics: Observations on the Relatively Greater Frequency of Myodesopia in the Myopic Eye
Authors: J. Hogg
Journal: BMJ (1865)

British Medical JouraL!-toms of inflammation of the brain or its membranes.Should these symptoms arise, the pulse is the best index for treatment.On reference to Case iv, it will be seen that the patient was treated with stimulants from the first; but it will also be seen that his pulse was weak, and after the first day never over sixty, until just before his decease, when it mounted rapidly.Should, however, the pulse increase in number and volume, as in Case ii, small doses of calomel and counterirritation are the remedies; but it appeaxs that these patients bear the administration of mer- curiy less well than cases of the idiopathic form of this (lisease.The quantity, however, must be regulated by the state of the pulse.
Sharing of Medicare Claims Data
Authors: Niall Brennan
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PET/CT Appearance of Acute Pyelonephritis
Authors: Kevin C. McCammack, Nathan C. Hawkes, Eugene D. Silverman, David A. Paz
Journal: Clinical Nuclear Medicine (2013)

An 18-year-old male patient with a history of Ewing sarcoma originally involving the right ilium was evaluated with an FDG PET/CT scan to evaluate the effect of salvage therapy after standard treatment failed and disease progressed to involve the right T12 pedicle. Autologous stem cell transplantation and cyberknife therapy resulted in mixed tumor response, with incidental note made of prominent areas of cortical FDG avidity in the right kidney. These regions demonstrated focal hypoenhancement on the corresponding diagnostic contrast-enhanced CT, which additionally demonstrated peripheral enhancement spanning the length of the right ureter. Clinical workup produced a diagnosis of acute pyelonephritis.
Aprotinin Inhibits Plasmin-Induced Platelet Activation During Cardiopulmonary Bypass
Authors: Osamu Shigeta, Hiroshi Kojima, Tomoaki Jikuya, Yasushi Terada, Naotaka Atsumi, Yuzuru Sakakibara, Toshiro Nagasawa, Toshio Mitsui
Journal: Circulation (1997)

In the past few years, aprotinin has been used in cardiac surgery with impressive results of reducing blood loss, but several adverse effects of aprotinin also have been reported. One of the most likely mechanisms is the inhibition of plasmin by aprotinin, although this indirect effect has not been reproduced in all experimental studies.We evaluated the platelet function and fibrinolytic activity during human cardiac surgery, with or without aprotinin. During cardiopulmonary bypass (CPB) in humans without aprotinin (n=16), decrease of platelet aggregation induced by thrombin, increase of alpha-granule secretion of platelet and microparticle formation, and increase of plasmin/alpha2-antiplasmin complex (PIC) were observed. In contrast, low-dose aprotinin (1.0 x 10(6) KIU), which was administered only into the priming fluid of extracorporeal circuits (n=10), maintained platelet aggregation induced by thrombin and reduced alpha-granule secretion and microparticle formation of platelets during CPB. In vitro, plasmin (0.8 CU/mL) released alpha-granules of washed platelets, and this activation was completely inhibited by aprotinin (10 KIU/mL).Aprotinin has indirect effects to inhibit platelet activation, and this may partly explain the reduction of blood loss during cardiac surgery. To prevent the adverse effects, a single and minimal use of aprotinin is important. The results of in vivo and in vitro studies suggest that platelet preservation was demonstrated by the lower concentration of aprotinin (1.0 x 10(6) KIU per patient or 10 KIU/mL) compared with the concentration that inhibits plasma fibrinolysis.
A Viennese Waltz
Authors: Bruno Gebhard
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Successful therapy of idiopathic dilated cardiomyopathy by IgG immunosdsorption, results of a controlled study
Authors: J. Müller, G. Wallukat, K. Brandes, S. Spiegelsberger, H. Bieda, W. Kupetz, M. Hummel, R. Hetzer
Journal: Journal of the American College of Cardiology (1998)
Assessing fitness to practise: Common sense approach to revalidation/accreditation
Authors: Anton E A Joseph
Journal: BMJ (2006)

EDITOR—The controversial and impractical route for revalidation proposed by the General Medical Council based on legislation is for doctors to provide evidence that they are up to date and fit to practise. Ever since, the debate has ranged from how this might be achieved to questioning the validity of revalidation itself. I prefer the more complimentary “accreditation”to “revalidation.”

Government and regulatory …
Development and validation of a bayesian model for perioperative cardiac risk assessment in a cohort of 1,081 vascular surgical candidates
Authors: Gilbert J. L'Italien, Sumita D. Paul, Robert C. Hendel, Jeffrey A. Leppo, Mylan C. Cohen, Lee A. Fleisher, Kenneth A. Brown, Stuart W. Zarich, Richard P. Cambria, Bruce S. Cutler, Kim A. Eagle
Journal: Journal of the American College of Cardiology (1996)
Compendiosa totius in anatomie delineatio.
Authors: Ashley Montagu
Journal: JAMA (1963)

This excellent folio is a facsimile edition of the first English edition of 1553, in the version of Nicholas Udall (the father of English comedy), of Thomas Geminus' plagiarism of Vesalius'<i>Epitome</i>. It is today generally acknowledged that Geminus' original Latin plagiarism, published in 1545, and this later, and far superior, English version did more to make Vesalius' work known throughout Europe than Vesalius' own writings. Geminus' copper engravings of Vesalius' woodcuts are very creditable performances, and the title page which he engraved for the Udall translation is generally considered to be one of the first of its kind worthy of the name of art. In the history of medicine the Udall translation of the<i>Epitome</i>is of considerable importance, because it was the first work of its kind especially produced for the benefit of the newly organized guild of physicians and surgeons in England, and there is every evidence
Evaluation of antifungal effects of terbinafine and itraconazole using neutral red staining
Authors: T. NISHIKAWA, W. NAKA
Journal: British Journal of Dermatology (1994)

Neutral red staining is a newly described method for evaluating the viability of fungal cells. Using this method, the antifungal effects of terbinatine and itraconazole were evaluated in vitro. When the number of neutral red-positive Trichophyton mentagrophytes conidia treated with these two oral antifungals was compared with the number of culture-proved viable T. mentagrophytes conidia, a strong positive correlation was found. This result confirms that neutral red staining is a useful method for evaluating the viability of T. mentagrophytes in vitro, and that it can be used for the evaluation of antifungal activity. We conclude that the effectiveness of an antifungal drug should not be evaluated by direct microscopic examination alone, but with the additional aid of mycological culture or neutral red staining.
Healthcare commissioners need clearer expectations and longer funding rounds, says NHS regulator
Authors: Z. Kmietowicz
Journal: BMJ (2013)

Commissioners of healthcare should be given budgets for more than a year so that they do not need to renew contracts with providers annually, the health regulator for England has said. This would give them greater financial stability and planning ability, it said.

The recommendation on how the NHS Commissioning Board should promote commissioning was included in a review by the regulator, Monitor, of what constitutes a “fair playing field” for the various potential providers of NHS healthcare.1

Altogether Monitor made 30 recommendations to the government, but it concluded that the key factor in whether patients can get the best care was how commissioners go about the task of securing services.

The review was commissioned last …
545 THE P53-PARALOG DNP73 ONCOGENE IS REPRESSED BY α-IFN/STAT2 THROUGH THE RECRUITMENT OF YY1 AND HDAC1 TRANSCRIPTIONAL REPRESSORS
Authors: B. Testoni, C. Scisciani, V. Schinzari, N. Pediconi, M. Levrero
Journal: Journal of Hepatology (2009)
Neural Correlates of Recall of Life Events in Conversion Disorder
Authors: Selma Aybek, Timothy R. Nicholson, Fernando Zelaya, Owen G. O’Daly, Tom J. Craig, Anthony S. David, Richard A. Kanaan
Journal: JAMA Psychiatry (2013)

Freud argued that in conversion disorder (CD) the affect attached to stressful memories is "repressed" and "converted" into physical symptoms, although this has never been subject to scientific study to our knowledge.To examine the neural correlates of recall of life events judged to be of causal significance in CD.Case-control study. Academic research setting among 12 patients with motor CD and 13 healthy control subjects.Stressful life events were assessed using the Life Events and Difficulties Schedule and rated by a blinded panel for their likelihood to cause CD based on the threat posed and the extent to which subsequent illness might allow escape from some of their consequences (termed escape). Recall of those events (escape condition) was compared with recall of equally threatening control events from the same epoch (severe condition) in a functional magnetic resonance imaging task.Relative to controls, patients showed significantly increased left dorsolateral prefrontal cortex and decreased left hippocampus activity during the escape vs severe condition, accompanied by increased right supplementary motor area and temporoparietal junction activity. Relative to controls, patients failed to activate the right inferior frontal cortex during both conditions, and connectivity between amygdala and motor areas (supplementary motor area and cerebellum) was enhanced.These data offer support for the notion that the way adverse events are processed cognitively can be associated with physical symptoms in CD. Abnormal emotion (dorsolateral prefrontal cortex and right inferior frontal cortex) and memory control (hippocampus) are associated with alterations in symptom-related motor planning and body schema (supplementary motor area and temporoparietal junction).
Gli2 and p53 Cooperate to Regulate IGFBP-3- Mediated Chondrocyte Apoptosis in the Progression from Benign to Malignant Cartilage Tumors
Authors: Louisa Ho, Aneta Stojanovski, Heather Whetstone, Qing Xia Wei, Elaine Mau, Jay S. Wunder, Benjamin Alman
Journal: Cancer Cell (2009)
Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance
Authors: Tomohiro Fukaya, Hideaki Takagi, Yumiko Sato, Kaori Sato, Kawori Eizumi, Honami Taya, Tahiro Shin, Lieping Chen, Chen Dong, Miyuki Azuma, Hideo Yagita, Bernard Malissen, Katsuaki Sato
Journal: Blood (2010)
Genetic Susceptibility to Hepatic Steatosis
Authors: Anna Mae Diehl
Journal: New England Journal of Medicine (2010)

Noninvasive imaging techniques that quantify tissue triglyceride content, such as proton nuclear magnetic resonance spectroscopy, have shown that the accumulation of triglycerides in the liver (i.e., steatosis) is a highly prevalent condition, occurring in up to one third of adults in the United States.1 Steatosis is associated with increased mortality from cardiovascular disease, cancer, and liver disease, even after adjustment for other potentially confounding coexisting disorders such as obesity and type 2 diabetes mellitus.2 Therefore, it is important to understand the processes that regulate hepatic triglyceride content.The major risk factor for hepatic steatosis is excessive consumption of food, alcohol, . . .
Role of NADPH oxidase-mediated superoxide production in the regulation of E-selectin expression by endothelial cells subjected to anoxia/reoxygenation
Authors: A RUPIN
Journal: Cardiovascular Research (2004)

Anoxia followed by reoxygenation (A/R) increases endothelial cell superoxide (O2-) generation which is implicated in E-selectin overexpression. The mechanisms which govern these processes are not fully understood and therefore the goal of our study was to determine the functional importance of NADPH oxidase in the regulation of E-selectin expression in human umbilical veins endothelial cells (HUVECs) submitted to A/R.O2- production was estimated using lucigenin chemiluminescence and formazan accumulation. NADPH oxidase expression in HUVECs was studied by RT-PCR and Western blot and E-selectin by Northern blot analysis. NFkappaB activation was assessed by electrophoretic mobility shift assay.A/R caused an increased O2- production which was inhibited by the superoxide dismutase mimetic M40403 (50 micromol/l), the protein kinase C inhibitor chelerythrine (10 micromol/l), the NADPH oxidase inhibitor diphenyleneiodonium (DPI, 10 micromol/l) and the NADPH oxidase assembly blocker apocynin (600 micromol/l). At the end of the anoxic period, the mRNA expression and the protein p47phox was increased as compared to normoxic HUVECs. NFkappaB activation of anoxic HUVECs was maximal after 1 h of reoxygenation and returned to basal normoxic levels after 2 h of reoxygenation. Apocynin reduced the NFkappaB activation at 1 h of reoxygenation. E-selectin mRNA expression was increased after 3 h of reoxygenation of anoxic HUVECs and the SOD mimetic M40403 as well as apocynin prevented this overexpression.Activated NADPH oxidase is a critical enzyme in E-selectin overexpression after A/R of HUVECs. Moreover, A/R increased expression of membranous and cytosolic NADPH oxidase subunits as well as the protein p47phox. Strategies aimed at preventing endothelial NADPH oxidase activation and/or activity may be useful in controlling leukocyte adhesion during ischemia/reperfusion.
The association of reduced folate carrier 80G&gt;A polymorphism to outcome in childhood acute lymphoblastic leukemia interacts with chromosome 21 copy number
Authors: Jannie Gregers, Ib Jarle Christensen, Kim Dalhoff, Birgitte Lausen, Henrik Schroeder, Steen Rosthoej, Niels Carlsen, Kjeld Schmiegelow, Curt Peterson
Journal: Blood (2010)
1114. Bone Regeneration by Osteogenic Gene Delivery without Cell Transplantation Using Supramolecular Nanocarrier
Authors: Keiji Itaka, Kayo Masago, Shinsuke Oba, Ung-il Chung, Kazunori Kataoka
Journal: Molecular Therapy (2006)

In the fields of tissue engineering, the exotic gene introduction for regulating the cell function and differentiation is one of the most decisive and important issues. For this purpose, a novel type of supramolecular nanocarrier was developed. This system is based on the self-assembly of poly(ethylene glycol) (PEG)-polycation block copolymers and pDNA, forming polyplex micelles through an electrostatic interaction.
146. T Cell Response Against the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene
Authors: Maria Limberis, Joanita Figueredo, James M. Wilson
Journal: Molecular Therapy (2005)

Top of pageAbstract
Gene therapy for cystic fibrosis airway disease appears to be the most promising curative option and much effort has been focused on developing gene transfer vectors combined with ways to manipulate the barriers that the airway poses to gene transfer. However, there has been no evaluation of the possibility of a T cell response against the CFTR gene in the context of gene therapy. Although this may not be a limitation in the majority of CF patients which express residual amounts of CFTR, the likelihood of immune responses against CFTR must be investigated.

As such we designed a peptide library of the human CFTR consisting of 294 peptides of 15 amino acids (aa) each with an overlapping 10 aa sequence. In the first instance we evaluated the immune response generated by an adenovirus (Ad) vector expressing the hCFTR gene under the transcriptional control of the chicken b-actin promoter in CFTR knockout as well as CFTR heterozygote mice. Specifically, 5e10 particles of an Ad vector were injected intramuscularly into the right hindlimb of CFTR knockout and CFTR heterozygote mice. Eight days later the mice were sacrificed and the spleens harvested. T cell response was assayed using IFN-g ELISPOT following stimulation of splenocytes with 15 pools (20 peptides/pool, final concentration of 2.5 mg/ml) of the CFTR peptide library. A T cell response was observed in 7 out of 15 peptide pools and we are currently screening those in an attempt to map the epitopes. The pattern of the T cell immune response observed was almost similar in both groups. However, we identified a minor epitope in the CFTR knockout group that did not show any activity in the CFTR heterozygote group suggesting that high levels of CFTR may not compromise pre-existing tolerance. We are examining whether the T cell response is CD4 or CD8 cell mediated and also evaluating T cell activation against CFTR following an intranasal instillation of varying doses of Ad-CFTR vector.

In conclusion, this study will help elucidate whether a T cell response is generated following CFTR gene transfer and assess how this will affect the outcome of CFTR gene therapy in a clinical setting.
Intermittent high-dose dexamethasone-cyclophosphamide therapy for pemphigus
Authors: J.S. PASRICHA, J. THANZAMA, UTTAM KHAN
Journal: British Journal of Dermatology (1988)

Since 1982, we have treated 79 pemphigus patients with an arbitrarily designed regimen of 100 mg dexamethasone dissolved in 5% glucose given by an intravenous infusion over 1 h, daily on 3 consecutive days and in addition, 500 mg cyclophosphamide on day 1 only. The intermittent high doses (IHD) of dexamethasone are repeated every 2-4 weeks, and the patient continues to take 50 mg/day oral cyclophosphamide. This treatment is divided into four phases. During Phase I, the patient continues to develop relapses of pemphigus a variable number of days after IHD, but the lesions heal up quickly after IHD. These relapses become progressively milder and stop after a few months, but the IHD are continued once a month for 6-9 months (Phase II). In the next phase (Phase III), the monthly IHD are stopped, and the patient continues to take 50 mg/day cyclophosphamide orally. After approximately 1 year this maintenance treatment is withdrawn and the patient is observed for any relapses (Phase IV). Of the 79 patients treated, 10 patients have been lost to follow-up and two have died, one due to leukopaenia caused by inadvertent additional administration of methotrexate, and the other of an unknown cause. Of the remaining 67 patients, 25 are off treatment (Phase IV), 25 are taking only 50 mg cyclophosphamide daily (Phase III), ten are also in remission, but still receiving intermittent high doses of dexamethasone-cyclophosphamide (Phase II), and seven still have active disease (Phase I).(ABSTRACT TRUNCATED AT 250 WORDS)
NOTE ON A NEW METHOD OF PRODUCING HAEMOLYSINS
Authors: M. A. Ruffer, M. Crendiropoulo
Journal: BMJ (1903)

PRODUOING HAEMOLYSINS.[A , appeared, and the liver could not be felt below the ribs.At this stage a slight convergent strabismus was noticed fr two days.Its ominous significance was not at once apparent; a day later, however, a hydrocephalic cry announced the presence of taberculous meningitis.This was followed by convulsions, which lasted with intermissions till death took place thirty hours later, and six days after the abscess had been opened.Though the ending to this case was disappointing, seeing that incising the abscess had afforded such marked relief, ,nevertheless, on account of the early age of the patient, I think it one worth recording.
HCV and HGV in B-cell non-Hodgkin's lymphoma
Authors: Volker Ellenrieder, Hans Weidenbach, Norbert Frickhofen, Detlef Michel, Otto Prümmer, Stefan Klatt, Oliver Bernas, Thomas Mertens, Guido Adler, Karlheinz Beckh
Journal: Journal of Hepatology (1998)