Resolution of a Contraceptive-Steroid-Induced Hepatic Adenoma with Subsequent Evolution into Hepatocellular Carcinoma
Authors: STUART C. GORDON
Journal: Annals of Internal Medicine (1986)

Brief Reports1 October 1986Resolution of a Contraceptive-Steroid-Induced Hepatic Adenoma with Subsequent Evolution into Hepatocellular CarcinomaSTUART C. GORDON, M.D., K. RAJENDER REDDY, M.D., ALAN S. LIVINGSTONE, M.D., LENNOX J. JEFFERS, M.D., EUGENE R. SCHIFF, M.D.STUART C. GORDON, M.D.Search for more papers by this author, K. RAJENDER REDDY, M.D.Search for more papers by this author, ALAN S. LIVINGSTONE, M.D.Search for more papers by this author, LENNOX J. JEFFERS, M.D.Search for more papers by this author, EUGENE R. SCHIFF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-4-547 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe causal relationship between contraceptive steroids and hepatic adenomas is well established (1). A similar etiologic relationship between contraceptive steroids and hepatocellular carcinoma remains unsettled. Furthermore, whether known contraceptive-steroid-related adenomas may dedifferentiate into hepatocellular carcinoma is equally uncertain. We report the case of a woman in whom an hepatocellular carcinoma arose in an area where a contraceptive-steroid-induced adenoma had previously regressed.In August 1977, a 36-year-old white woman presented with epigastric fullness and a palpable mass in her right upper abdomen. The patient had been taking contraceptive steroids for the previous 14 years and, specifically, a combination agent containing norethindrone...References1. KLATSKIN G. Hepatic tumors: possible relation to use of oral contraceptives. Gastroenterology. 1977;73:386-94. CrossrefMedlineGoogle Scholar2. GOODMANISHAK ZK. Hepatocellular carcinoma in women: probable lack of etiologic association with oral contraceptive steroids. Hepatology. 1982;2:440-4. CrossrefMedlineGoogle Scholar3. GOLDFARB S. Sex hormones and hepatic neoplasia. Cancer Res. 1976;36(7 pt 2):2584-8. MedlineGoogle Scholar4. TESLUKLAWRIE HJ. Hepatocellular adenoma: its transformation to carcinoma in a user of oral contraceptives. Arch Pathol Lab Med. 1981;105:296-9. MedlineGoogle Scholar5. BAUMBOOKSTEINHOLTZKLEIN JJFE. Possible association between benign hepatomas and oral contraceptives. Lancet. 1973;2:9269. Google Scholar6. STAUFFERLAPINSKIHONOLDMYERS JMDJ. Focal nodular hyperplasia of the liver and intrahepatic hemorrhage in young women on oral contraceptives. Ann Intern Med. 1975;83:301-6. LinkGoogle Scholar7. ROSSPINAMIRZAGALVANPONCE DJMAL. Regression of focal nodular hyperplasia after discontinuation of oral contraceptives [Letter]. Ann Intern Med. 1976;85:203-4. LinkGoogle Scholar8. DAVISPORTMANNSEARLEWRIGHTWILLIAMS MBMRR. Histological evidence of carcinoma in a hepatic tumour associated with oral contraceptives. Br Med J. 1975;4:496-8. CrossrefMedlineGoogle Scholar9. NEUBERGERPORTMANNNUNNERLEYLAWSDAVISWILLIAMS JNHJMR. Oral-contraceptive-associated liver tumours: occurrence of malignancy and difficulties in diagnosis. Lancet. 1980;1:273-6. CrossrefMedlineGoogle Scholar10. EDMONDSONREYNOLDSHENDERSONBENTON HTBB. Regression of liver cell adenomas associated with oral contraceptives. Ann Intern Med. 1977;86:180-2. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: STUART C. GORDON, M.D.; K. RAJENDER REDDY, M.D.; ALAN S. LIVINGSTONE, M.D.; LENNOX J. JEFFERS, M.D.; EUGENE R. SCHIFF, M.D.Affiliations: Center for Liver Diseases University of Miami School of Medicine Veterans Administration Medical Center Miami, Florida PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDevelopment of Liver Cancers as an Unexpected Consequence of Anabolic Androgenic Steroid UseA Shifting Paradigm in Diagnosis and Management of Hepatic AdenomaHepatocellular AdenomaMalignant transformation of hepatocellular adenoma with bone marrow metaplasia arising in glycogen storage disease type I: A case reportContrast-Enhanced Ultrasound of Focal Liver LesionsImaging of the Liver and Bile Ducts: Radiographic and Clinical Assessment of FindingsHepatocellular AdenomaNew advances in hepatocellular carcinomaHepatocellular adenoma with malignant transformation in male patients with non-cirrhotic liversManagement of Hepatic AdenomatosisHepatocellular carcinoma arising in adenoma: similar immunohistochemical and cytogenetic features in adenoma and 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