tbuckley/cabot-search huggingface dataset:
T‐ALL with monoclonal gammopathy and hairy cell features
Authors: Sevgi Yetgin, Lale Olcay, Leman Yel, Murat Tuncer, İlhan Tezcan, Esra Erdemli, Ahmet Faik Öner, Frederick G. Behm
Journal: American Journal of Hematology (2000)

The presented case is a boy with T-cell acute lymphoblastic leukemia (ALL) with hairy cell (HC) features and monoclonal gammopathy. The disease process had an acute onset and followed a rapid, progressive course. The patient had minimal splenomegaly and bicytopenia, but the bone marrow displayed increased numbers of reticulin fibers. The blasts were positive for tartrate-resistant acid phosphatase (TRAP) and CD11c. Molecular analysis revealed rearrangement of immunoglobulin heavy chain genes and a rearranged T-cell receptor (TcRβ) beta gene. The patient responded to conventional ALL therapy. Acute T-cell ALL with HC features in childhood has not been reported previously, either alone or in association with monoclonal gammopathy. We propose “T-ALL with hairy cell features” to describe this case. Am. J. Hematol. 65:166–170, 2000. © 2000 Wiley-Liss, Inc.
Higher order wavefront aberrations of cornea and magnitude of refractive correction in laser in situ keratomileusis
Authors: Tetsuro Oshika, Kazunori Miyata, Tadatoshi Tokunaga, Tomokazu Samejima, Shiro Amano, Sumiyoshi Tanaka, Yoko Hirohara, Toshifumi Mihashi, Naoyuki Maeda, Takashi Fujikado
Journal: Ophthalmology (2002)
Differential WNT Activity in Colorectal Cancer Confers Limited Tumorigenic Potential and Is Regulated by MAPK Signaling
Authors: David Horst, Justina Chen, Teppei Morikawa, Shuji Ogino, Thomas Kirchner, Ramesh A. Shivdasani
Journal: Cancer Research (2012)

Abstract Colorectal cancers (CRC) express the WNT effector protein β-catenin in a heterogeneous subcellular pattern rather than uniformly in the nucleus. In this study, we investigated this important aspect of molecular heterogeneity in CRCs by analyzing its basis and relationship with tumor-initiating capability. CRC cells with the highest WNT levels showed only a marginal increase in tumor initiation capacity. Notably, high WNT activity correlated with a coincident activation of robust mitogen-activated protein kinase (MAPK) signaling, which when upregulated by KRAS expression or downregulated by epidermal growth factor receptor inhibition elicited parallel effects on WNT activity. These findings suggested that on its own high WNT activity may not be a reliable signifier of tumor-initiating potential or stem-like potential. Furthermore, they suggest that MAPK signaling is a critical modifier of intratumoral heterogeneity that contributes significantly to determining the impact of WNT activity on stemness phenotypes in colon cancer cells. Cancer Res; 72(6); 1547–56. ©2012 AACR.
Male-biased sex ratios of fish embryos near a pulp mill: temporary recovery after a short-term shutdown.
Authors: D G Joakim Larsson, Lars Förlin
Journal: Environmental Health Perspectives (2002)

In a previous study we showed that broods from the viviparous eelpout Zoarces viviparus were significantly male biased in 1998 in the vicinity of a large kraft pulp mill on the Swedish Baltic coast. One suggested hypothesis was that masculinizing compounds in the effluent were affecting gonadal differentiation of the embryos, resulting in skewed sex ratios. In this article, we present further evidence for a causal relationship between the exposure to the effluent and the male-biased sex ratios. Analyses of historical samples showed that the eelpout produced male-biased broods close to the mill in 1997 in addition to 1998. During 1999, the mill was shut down for 17 days, coinciding with the period when the gonads of the eelpout embryos differentiate. Subsequently, in the fall of 1999, the sex ratios were no longer male biased; however, the following year (2000), a significant male bias reappeared. Investigations at 13 sites for up to 4 years showed a relatively stable sex ratio around 50/50, with the exceptions by the mill and with few observations of deviating ratios at other sites. Several reports document endocrine disturbances in fish near pulp and paper mills, including the expression of male secondary sex characters in female fish. The repeatedly identified male bias at the investigated mill, the normalization after mill shutdown, and the reappearance the following year indicate that pulp mill effluents also can affect sex ratios of nearby fish.
Additional George IV and The Journal
Authors: Gerald P. Rodnan
Journal: JAMA (1966)

<h3>To the Editor:—</h3> The caricature published on the cover of the Nov 29 issue (1965) likewise portrayed George IV, after he had ascended the throne. It was originally entitled<i>All the World's a Stage,— And One Man in his time plays many parts etc</i>. The artist is believed to have been W. Heath; the publisher was S. W. Fores of London. The portraits on the wall behind the King illustrate phases of his past life, beginning as a slim young archer and ending as an obese figure in coronation robes and Highland costume. The wine bottle on the table next to the monarch may have contained port, as the caption on your cover suggests, but it is recorded that he preferred claret and madeira. The regent and his gout became the butt, not only of the caricaturists, but of many of the poets and essayists of the period, including Byron,
Stent flexibility: an essential feature in the treatment of dynamic airway collapse
Authors: H Hautmann, RM Huber
Journal: European Respiratory Journal (1996)

Implantation of endobronchial stents for treatment of dynamic airway collapse represents a suitable therapeutic option to alleviate distressing symptoms. We report the case of a 43 year old patient suffering from progressive respiratory distress 2 weeks after insertion of a balloon-expandable radial noncompliant Palmaz stent in an unstable segment of the left main bronchus, with the aim of preventing symptomatic airway collapse. Bronchial instability had developed following sleeve resection of the right lung due to adenoid cystic carcinoma. Explanation revealed compression and deformation of the stent. Peak expiratory flow (PEF) had declined a low of 1.38 L.s-1 (forced expiratory volume in one second (FEV1) 1.02 L). With placement of a Strecker stent, having the ability to re-expand within certain limits, bronchial collapse could be avoided and marked clinical improvement as well as expiratory flow increase was noted (PEF 7.10 L.s-1; FEV1 = 2.03 L). At 13 months follow-up, clinical status was unchanged. A decline in forced expiratory flow (PEF 5.96 L.s-1; FEV1 1.69 L), however, indicated a possible change in the structural integrity of the Strecker stent. We conclude that physical properties of endobronchial stents may be crucial for good functional results in major airway collapse. Stiff prostheses, when compressed, can induce severe airway obstruction.
Dasatinib may overcome the negative prognostic impact of KIR2DS1 in newly diagnosed patients with chronic myeloid leukemia
Authors: Sara Ali, Ruhena Sergeant, Stephen G. O'Brien, Letizia Foroni, Corinne Hedgley, Gareth Gerrard, Dragana Milojkovic, Kate Stringaris, Ahmad Khoder, Abdullah Alsuliman, Maria Gilleece, Ian H. Gabriel, Nichola Cooper, John M. Goldman, Jane F. Apperley, Richard E. Clark, David Marin, Katayoun Rezvani
Journal: Blood (2012)
Detection of Early Esophageal Cancer and Cervical Lymph Node Metastases by 18F-FDG PET/CT in a Patient With Fanconi Anemia
Authors: Tamaki Ichikawa, Jun Hashimoto, Miharu Yabe, Tomoki Kikuchi, Yutaka Imai
Journal: Clinical Nuclear Medicine (2014)

Fanconi anemia is a rare autosomal recessive disease characterized by multiple congenital anomalies, pancytopenia, and cancer susceptibility, especially to leukemia and squamous cell carcinoma of the head and neck or esophagus. 18F-FDG PET/CT is a useful tool to assess tumor staging and follow-up of esophageal cancer. We report a rare case of cervical esophageal cancer and lymph node metastases detected on 18F-FDG PET/CT in a patient with Fanconi anemia after bone marrow transplantation.
Effect of Lung Denervation on Pulmonary Hypertension and Edema
Authors: DONALD J. FERGUSON, ERNEST M. BERKS, Robert W. Frykman, John Ognanovich
Journal: Circulation Research (1957)

Under conditions of high pulmonary artery pressure and flow produced in dogs by a controlled systemic artery shunt, pulmonary edema occurred after denervation of the lung at arterial pressures that were tolerated without edema before denervation. Left atrial pressures were not altered by the shunt, which involved only one segment of lung. Observation of animals with shunts for 1½ to 10 months showed that denervation apparently did not affect the incidence of arteriosclerosis.
Ranking 37th — Measuring the Performance of the U.S. Health Care System
Authors: Christopher J.L. Murray, Julio Frenk
Journal: New England Journal of Medicine (2010)

Evidence that other countries perform better than the United States in ensuring the health of their populations is a sure prod to the reformist impulse. The World Health Report 2000, Health Systems: Improving Performance, ranked the U.S. health care system 37th in the world1 — a result that has been discussed frequently during the current debate on U.S. health care reform.The conceptual framework underlying the rankings2 proposed that health systems should be assessed by comparing the extent to which investments in public health and medical care were contributing to critical social objectives: improving health, reducing health disparities, protecting households . . .
Variation in Adenovirus Receptor Expression and Adenovirus Vector-Mediated Transgene Expression at Defined Stages of the Cell Cycle
Authors: Michael A. Seidman, Suzanne M. Hogan, Rebecca L. Wendland, Stefan Worgall, Ronald G. Crystal, Philip L. Leopold
Journal: Molecular Therapy (2001)

Detailed investigations have addressed the infection pathway of recombinant adenovirus (Ad) gene transfer vectors, but little attention has been paid to the influence of cell physiology on the outcome of Ad infection. Based on observations that Ad infection of clonal cell populations show cell-to-cell variability in the extent of capsid binding, we hypothesized that the cell cycle may influence the outcome of Ad infection. To address this hypothesis, we evaluated Ad association with cells in both unsynchronized and pharmacologically synchronized cell populations. In unsynchronized cell populations, elevated Ad association with cells correlated with expression of cyclin B1, a marker of entry into the M phase of mitosis. The same analysis conducted on cell populations that were synchronized at M phase (using paclitaxel or nocodazole) or at S phase (using aphidicolin) confirmed that M phase cells bound three- to sixfold more capsid compared with unsynchronized cells, which are primarily in the G1 and G2 phases. The elevated association of vectors with cells translated into 2.5- to 4-fold greater transgene expression 24 hours after infection. Assessment of cell surface expression of Ad receptors demonstrated that both the high-affinity coxsackie-adenovirus receptor for Ad fiber protein and the low-affinity αv inte-grin receptor for Ad penton base protein showed increased cell surface expression at M phase (1.5-fold and 2- to 3-fold increases, respectively). These data demonstrate that Ad infection of a homogenous population of cells can vary depending on the cell cycle stage, with enhanced Ad binding and expression correlating with the enhanced expression of Ad receptors during M phase. These observations have relevance to understanding the mechanisms of gene transfer by Ad vectors and should help in the design of in vivo gene transfer strategies.
Evaluation of the Association of Maternal Pertussis Vaccination With Obstetric Events and Birth Outcomes
Authors: Elyse O. Kharbanda, Gabriela Vazquez-Benitez, Heather S. Lipkind, Nicola P. Klein, T. Craig Cheetham, Allison Naleway, Saad B. Omer, Simon J. Hambidge, Grace M. Lee, Michael L. Jackson, Natalie L. McCarthy, Frank DeStefano, James D. Nordin
Journal: JAMA (2014)

In 2010, due to a pertussis outbreak and neonatal deaths, the California Department of Health recommended that the tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) be administered during pregnancy. Tdap is now recommended by the Advisory Committee on Immunization Practices for all pregnant women, preferably between 27 and 36 weeks' gestation. Limited data exist on Tdap safety during pregnancy.To evaluate whether maternal Tdap vaccination during pregnancy is associated with increased risks of adverse obstetric events or adverse birth outcomes.Retrospective, observational cohort study using administrative health care databases from 2 California Vaccine Safety Datalink sites.Of 123,494 women with singleton pregnancies ending in a live birth between January 1, 2010, and November 15, 2012, 26,229 (21%) received Tdap during pregnancy and 97,265 did not.Risks of small-for-gestational-age (SGA) births (<10th percentile), chorioamnionitis, preterm birth (<37 weeks' gestation), and hypertensive disorders of pregnancy were evaluated. Relative risk (RR) estimates were adjusted for site, receipt of another vaccine during pregnancy, and propensity to receive Tdap during pregnancy. Cox regression was used for preterm delivery, and Poisson regression for other outcomes.Vaccination was not associated with increased risks of adverse birth outcomes: crude estimates for preterm delivery were 6.3% of vaccinated and 7.8% of unvaccinated women (adjusted RR, 1.03; 95% CI, 0.97-1.09); 8.4% of vaccinated and 8.3% of unvaccinated had an SGA birth (adjusted RR, 1.00; 95% CI, 0.96-1.06). Receipt of Tdap before 20 weeks was not associated with hypertensive disorder of pregnancy (adjusted RR, 1.09; 95% CI, 0.99-1.20); chorioamnionitis was diagnosed in 6.1% of vaccinated and 5.5% of unvaccinated women (adjusted RR, 1.19; 95% CI, 1.13-1.26).In this cohort of women with singleton pregnancies that ended in live birth, receipt of Tdap during pregnancy was not associated with increased risk of hypertensive disorders of pregnancy or preterm or SGA birth, although a small but statistically significant increased risk of chorioamnionitis diagnosis was observed.
Hemoglobinopathy with prolonged bactermia. A report of two cases
Authors: R. A. Finley
Journal: JAMA (1975)

Prolonged<i>Escherichia coli</i>bacteremia occurred as a complication of pyelonephritis in two patients with abnormal hemoglobins (SC and SS), despite "appropriate" antibiotic therapy. Careful investigation in each case failed to account for the persistent sepsis. Pyogenic arthritis ultimately developed in both patients. (<i>JAMA</i>234:718-721, 1975)
Management of Early Rectal T1 and T2 Cancers
Authors: Michael J. Stamos, Zuri Murrell
Journal: Clinical Cancer Research (2007)

Abstract The treatment of rectal cancer has undergone a tremendous surgical evolution over the past century. Initially, in the 19th century, the only possible safe treatment was a diverting colostomy, which then evolved first to local treatment, primarily via the Lisfranc and Kraske procedures (posterior approach), and later, in the 20th century, to the abdominal-perineal resection popularized by Miles. Subsequently, anterior resection and low anterior resection gained a solid foothold as the most efficacious ways to treat most cancers of the rectum. In the past 3 decades, transanal excision has reemerged as a popular treatment option for T1 and selected T2 rectal adenocarcinomas, allowing less morbidity for early cancers. The selection criteria for this treatment have often included mobile tumor, size &amp;lt;4 cm, favorable histology without lymphovascular invasion, and anatomic accessibility with the ability to achieve 1-cm circumferential margins. Although the use of transanal excision for T1 rectal cancer increased from 26% to ∼44% between 1989 and 2003, multiple recent retrospective studies have suggested that locoregional recurrence after this procedure is as high as 18% for T1 cancers and 47% for T2 cancers. Of interest, limited available prospective data reveal much better results (4-5% locoregional recurrence rate for T1 and 14-16% for T2). Much of the apparent discrepancy is due to patient selection, which is far more rigid in prospective trials. Conflicting data also exist as to how this outcome affects overall survival, although surgical salvage averages ∼50% with close follow-up. The following topics will be discussed in this article: the surgical evolution of rectal cancer, best patient selection criteria for transanal excision versus more radical operation, utility and effect of adjuvant therapy in early-stage rectal cancer, current trends in the treatment of early-stage rectal cancer, and current early-stage rectal cancer trials.
Ten-Year Status After Sympathectomy for Arteriosclerosis
Authors: Edward A. Edwards
Journal: JAMA (1961)

The progress of 100 patients, with and without diabetes, was followed for a period of years after treatment by lumbar sympathectomy. At the end of the tenth postoperative year, 42 patients were alive, and only 8 of these survivors were disabled by disease in their limbs. The life expectancy of patients whose limbs responded well to sympathectomy was greater than that of patients who failed to improve.
Signalling profile and antitumour activity of the novel Hsp90 inhibitor NVP-AUY922 in multiple myeloma
Authors: T Stühmer, A Zöllinger, D Siegmund, M Chatterjee, E Grella, S Knop, M Kortüm, C Unzicker, M R Jensen, C Quadt, P Chène, J Schoepfer, C García-Echeverría, H Einsele, H Wajant, R C Bargou
Journal: Leukemia (2008)
Unchanged myocardial tissue perfusion following pericardiotomy in acutely loaded cat hearts
Authors: J. LEKVEN
Journal: Cardiovascular Research (1981)

Journal Article Unchanged myocardial tissue perfusion following pericardiotomy in acutely loaded cat hearts Get access JON LEKVEN JON LEKVEN * From the Surgical Research Laboratory, Haukeland Hospital, University of Bergen, Norway *Address for reprints: Dr Jon Lekven, Surgical Research Laboratory, Haukeland Hospital, University of Bergen, N-5016 Bergen, Norway. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 15, Issue 2, February 1981, Pages 74–79, https://doi.org/10.1093/cvr/15.2.74 Published: 01 February 1981
Heterogeneity of intermediate-stage HCC necessitates personalized management including surgery
Authors: Qiang Gao, Xiao-Ying Wang, Jian Zhou, Jia Fan
Journal: Nature Reviews Clinical Oncology (2014)

1 which focused on recent advances in the stratification of and treatment allocation for patients with intermediate-stage hepatocellular carcinoma (HCC), that is, Barcelona Clinic Liver Cancer (BCLC) stage B disease.We agree with the authors that the patient population with intermediatestage HCC is highly heterogeneous with regard to tumour burden, liver function, and clinical character istics.However, according to Forner et al., 1 trans arterial chemo embolization (TACE) and sorafenib should be the only standard treatments for intermediate-stage HCC.We disagree with this stance, as studies in both Eastern and Western countries have indicated that hepatic resection is safe and results in longer survival in selected patients with inter mediate-stage HCC as compared with TACE and/or sorafenib therapy. 2,3he current definition of intermediatestage (BCLC B) HCC is extensive multifocal disease without vascular invasion or extrahepatic spread in patients with preserved liver function and no cancer-related symptoms (Figure 1).The BCLC staging system is endorsed by the American Association for the Study of Liver Diseases (AASLD), the European Association for the Study of the Liver (EASL) and the European Organisation for Research and Treatment of Cancer (EORTC), and therefore, these organizations do not advocate hepatic resection in patients with BCLC B stage HCC. 4,5However, the BCLC treatment recommendations are based on findings in populations of patients with intermediatestage HCC as a whole and, therefore, do not provide guidance as to which modality will yield the best results in individual patients.As such, deviations from the guidelines are highly frequent in clinical practice.
THE MANUFACTUBE AND USE OF TIN SPLINTS.WITH SOME SPECIAL APPLIANCES.
Authors: ARTHUR T. MANN
Journal: JAMA (1905)

I have chosen this subject not because tin splints are not used but because the general practitioner does not realize how easily he can make them himself to fit each individual case, and because I have some special devices to offer which I have found of considerable value. Sheet tin is a material peculiarly adapted to form some of the common splints we are called on to use. It is thin and light, when shaped into a splint it has considerable firmness, and it is a material which is easily manipulated. The equipment is simple—a small vise, tin shears, a hammer, a 5-cent punch and a few small rivets. I have made all the splints which are illustrated in this article out of about 30 cents' worth of tin. I have a metalworker's hammer; it is a convenience, but most of my work has been done with a common, cheap, carpenter's hammer. A small block of soft metal or a piece of hard wood is a convenience.
Clinical Assessment of Hearing Impairment
Authors: David L. Gaspar
Journal: JAMA (2007)

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