tbuckley/cabot-search huggingface dataset:
18F-FDG PET/CT Imaging for Mixed Germ Cell Tumor in the Pineal Region
Authors: Soon-Ah Park, Tae Young Kim, See-Sung Choi, Chung-Yong Yang, Hun Soo Kim, Keum Ha Choi
Journal: Clinical Nuclear Medicine (2012)

Primary germ cell tumor (GCT) in the pineal region is very rare among all primary intracranial neoplasms. Here, we present the 18F-FDG PET/CT findings of a pineal mixed GCT in a 14-year-old boy. PET/CT showed little uptake of 18F-FDG in the mass in the pineal region, whereas MR imaging showed contrast enhancement of solid component and low-signal-intensity areas at the septa of the cystic mass. Pathologic examination after surgical resection revealed the lesion to be a mixed GCT, with components of a mature teratoma (90%) and choriocarcinoma (10%). PET scans could be useful in determining the degree of malignancy in mixed tumors.
Treating chronic inflammation of the Achilles tendon
Authors: Elizabeth M Theo, Milind M Deshpande, Herbert H Nehrlich, Isobel Knight, Hesham Elsolamy
Journal: BMJ (2004)

I have chronic Achilles tendinitis. An MRI scan has shown a few small foci of cystic degeneration within the thickened tendon. I am 63 and desperate to find a specialist in this field as I have had acute intermittent pain day and night for more than a year.

I recommend you to go to a physiotherapist and undergo phonophoresis with flufenamic acid gel. You may have to continue the therapy for at least two to three …
Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma
Authors: Janel L. Kopp, Guido von Figura, Erin Mayes, Fen-Fen Liu, Claire L. Dubois, John P. Morris, Fong Cheng Pan, Haruhiko Akiyama, Christopher V.E. Wright, Kristin Jensen, Matthias Hebrok, Maike Sander
Journal: Cancer Cell (2012)
Payments to injured professional jockeys in British horse racing (1996-2006)
Authors: M Turner, G Balendra, P McCrory
Journal: British Journal of Sports Medicine (2008)

To determine the direct and indirect cost of injuries in professional jockeys as a result of race riding.Cohort study.Professional horse racing.Professional jockeys in the UK registered with the Jockey Club.Payouts under the Professional Riders Insurance Scheme (PRIS) for injuries sustained by professional jockeys, which were recorded by the Jockey Club injury database between 1996 and 2006 inclusive.In the 11-year period of the study, there were 1328 injuries that resulted in jockeys missing a total of 71,509 days of racing, and as a result PRIS paid out 4,496,019 pounds sterling in compensation. Most injuries were minor, with a third of injured jockeys returning to race riding within 2 weeks and 45% of the claims receiving a payout of < 1000 pounds sterling. Almost half the claims were due to fractures, with the clavicle being the most common site of injury. Joint dislocations accounted for the highest insurance payout and the longest time off racing.Horse racing is a sport known to have a high risk of injury. This study has found that almost 4.5 million pounds sterling was spent on the injuries that were reported to PRIS during the 11-year time period 1996-2006. This study sheds light on the overall injury cost in professional horse racing and will form the basis for more formal health economic analysis.
Published Format of Clinical Trials
Authors: L. Harris
Journal: BMJ (1973)

study" listed by Short et al.3 is that of gastric acidity in patients with Siogren's syndrome.Furthermore, they have reviewed the question of gastric acidity in rheumatoid arthritis,3 particularly wit,h reference to Edstrom's studies.2The latter author found achlorhydria among 12-8% of patients with rheumatoid arthritis under 40 and 28-6% of those over 40, a higher incidence than in comparable control groups.Short et al. con- firmed these findings for the under 40 age group.While it may be questionable whether the data as presented by these workers can be subjected to proper statistical analysis the studies clearly deserve mention.Together with the point about Sjogren's syndrome they imply that studies of acid secretion should be done before implicating other factors- for example, anti-inflam,matory drugs-as a cause of hypergastrinaemia.-Iam, etc.,
Diagnosis and management of motor neurone disease
Authors: Christopher J McDermott, Pamela J Shaw
Journal: BMJ (2008)

Motor neurone disease is a devastating illness which leads to progressive paralysis and eventual death. We will discuss the presentation of motor neurone disease in primary care and update non-specialists on progress with regards to life prolonging interventions, better control of disease symptoms, and an increased understanding of disease mechanisms. Motor neurone disease is rare but patients often are aware of it, so this review should help non-specialists reassure patients in whom it is unlikely to be the diagnosis.
Knotted Intestinal Decompression Tube
Authors: Alan Herschman
Journal: JAMA (1968)

<h3>To the Editor:—</h3> Intestinal intubation is frequently employed in the management of small-bowel obstruction, a procedure from which complications have not been reported.<sup>1</sup>We recently encountered an intubation complication in a patient who had had a gastroenterostomy. The diagnosis was made from plain abdominal x-ray films and confirmed at surgery. The purposes of this report are to describe the roentgenographic findings and to propose a method of avoiding the complication. <h3>Report of a Case:—</h3> A 25-year-old woman had had a gastrojejunostomy two years previously at another hospital for peptic ulcer. The patient was admitted to our hospital in December 1967 with a perforated gastric ulcer just distal to the gastrojejunostomy site. Surgical closure was performed without gastric resection, and the patient was soon discharged on a strict ulcer regimen. Three days later, she was readmitted with intractable periumbilical and epigastric pain. Definitive resectional surgery was planned after several days of
Return to Low-Altitude Sickness: An Entity That Doesn't Exist
Authors: Phillip A. Hertzman
Journal: JAMA (1990)

<h3>To the Editor.—</h3> In the Questions and Answers section of the November 24 issue, the respondent asks if physicians practicing at high altitude have seen cases of "return to low-altitude sickness."<sup>1</sup>After 13 years of practice in Los Alamos (altitude, 2230 m [7300 ft]), I have not cared for any patients who complained of this illness. Because of the nature of the employment in Los Alamos, individuals here travel to low-altitude areas frequently. I wonder whether the patient described develops headaches and nausea when she travels to other low-altitude areas and particularly if it develops when she is not visiting her family in New Jersey.
Organized Medicine in the Progressive Era: The Move Toward Monopoly
Authors: Lester S. King
Journal: JAMA (1978)

The so-called Progressive era started in approximately 1900 and went through the first World War. Famous for muckraking, it was also the era of profound changes in the social, economic, and cultural life. Burrows shows how, during this period, organized medicine passed from political obscurity to public prominence in less than a decade and became a force for political reform. The Kentucky physician Joseph N. McCormick welded state societies into a coherent and powerful organization and worked hard to place the organization behind a program of improved public health, better medical education, and favorable public relations. In this book there are impressive chapters on reform in medical education and the role that the American Medical Association played therein, especially through its Council on Education. The great publicity that attended Simon Flexner and his famous Report of 1910 has obscured the part played by the AMA. Burrows tells the story well
Abstract 662: Role of FAM3B as a novel tumor suppressor gene in gastric cancer.
Authors: Hyojung Kim, Sujin Park, Jin Muk Kang, Staci Jakyong Kim, Seong-Jin Kim
Journal: Cancer Research (2013)

Abstract PANcreatic-DERived factor (PANDER, FAM3B) is a member of the FAM3 family of cytokine molecules. FAM3B expression is originally identified in the endocrine pancreas and also expressed in in colon and stomach. Initial characterization of FAM3B revealed a potential role in pancreatic islet apoptosis. However, the biological function of FAM3B has still remained elusive. Here we show that FAM3B level is decreased in 11 out of 14 cancer tissues samples (78.5%) as well as in gastric cancer cell lines. Ectopic expression of FAM3B leads to inhibition of cell growth and reduction of single cell colony forming activity and tumorigenicity of gastric cancer cells. FAM3B not only induces reduction of AKT phosphorylation, which is involved in cell survival, but also upregulation of p21, an inhibitor of cell cycle progression. We also demonstrated that FAM3B gene is silenced by epigenetic modification in gastric cancer cell lines. MS-275, a synthetic inhibitor of histone deacetylase, induced FAM3B gene expression. In conclusion, our data suggest the role of FAM3B as a putative tumor suppressor through downregulation of oncogenic AKT signaling pathway in gastric cancer. Citation Format: Hyojung Kim, Sujin Park, Jin Muk Kang, Staci Jakyong Kim, Seong-Jin Kim. Role of FAM3B as a novel tumor suppressor gene in gastric cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 662. doi:10.1158/1538-7445.AM2013-662
PREMENSTRUAL ELEVATION OF TEMPERATURE IN THE TUBERCULOUS WOMAN
Authors: EDWIN M. JAMESON
Journal: JAMA (1930)

The lack of any clear cut conception of the temperature changes to be expected during the days of and preceding the menses of normal and tuberculous women makes an analysis of a representative group of patients desirable. While it is well known in a general way that the woman suffering from tuberculosis tends to have a slightly elevated temperature during the premenstrual week, there is a strange diversity of opinion regarding the degree of elevation to be expected in patients who eventually go on to recovery, the duration of the rise, its relation to the menses, and the influence, if any, of the amount of tuberculosis which the patient presents. Bezançon's<sup>1</sup>careful study of the temperature variations in the normal organism presented a number of fundamental facts. Using the rectal temperature, he established as normal values, after at least one hour of repose, the following: between 7 and 8
Immune regulatory effects of panobinostat in patients with Hodgkin lymphoma through modulation of serum cytokine levels and T-cell PD1 expression
Authors: Y Oki, D Buglio, J Zhang, Y Ying, S Zhou, A Sureda, D Ben-Yehuda, P L Zinzani, H M Prince, S J Harrison, M Kirschbaum, P B Johnston, A Shen, B von Tresckow, A Younes
Journal: Blood Cancer Journal (2014)

Immune regulatory effects of panobinostat in patients with Hodgkin lymphoma through modulation of serum cytokine levels and T-cell PD1 expression
Scientific basis of gastroenterology
Authors: T S Low-Beer
Journal: Gut (1980)

Any criticism is minor and is aimed at the style of English-for example, 'small magnification of a liver', spelling-'pirmary biliary cirrhosis', or at the absence of bold type in the index to indicate the major text reference.Perhaps the authors are carried away by their approach and indulge in sign-splitting.Thus eight patterns of fibrosis and 11 types of liver cell necrosis are described.However, all pretenders to the kingdom of hepatopathology should be aware of this book which is a welcome breath of fresh air among the current fug of atlases.
p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest
Authors: Christian J. Braun, Xin Zhang, Irina Savelyeva, Sonja Wolff, Ute M. Moll, Troels Schepeler, Torben F. Ørntoft, Claus L. Andersen, Matthias Dobbelstein
Journal: Cancer Research (2008)

Abstract microRNAs provide a novel layer of regulation for gene expression by interfering with the stability and/or translation of specific target mRNAs. Overall levels of microRNAs are frequently down-regulated in cancer cells, and reducing general microRNA processing increases cancerogenesis in transgenic models, suggesting that at least some microRNAs might act as effectors in tumor suppression. Accordingly, the tumor suppressor p53 up-regulates miR-34a, a microRNA that contributes to apoptosis and acute senescence. Here, we used array hybridization to find that p53 induces two additional, mutually related clusters of microRNAs, leading to the up-regulation of miR-192, miR-194, and miR-215. The same microRNAs were detected at high levels in normal colon tissue but were severely reduced in many colon cancer samples. On the other hand, miR-192 and its cousin miR-215 can each contribute to enhanced CDKN1A/p21 levels, colony suppression, cell cycle arrest, and cell detachment from a solid support. These effects were partially dependent on the presence of wild-type p53. Antagonizing endogenous miR-192 attenuated 5-fluorouracil–induced accumulation of p21. Hence, miR-192 and miR-215 can act as effectors as well as regulators of p53; they seem to suppress cancerogenesis through p21 accumulation and cell cycle arrest. [Cancer Res 2008;68(24):10094–104]
The role of ceruloplasmin in iron metabolism
Authors: H. P. Roeser, G. R. Lee, S. Nacht, G. E. Cartwright
Journal: Journal of Clinical Investigation (1970)

The importance of ceruloplasmin in iron metabolism was studied in swine made hypoceruloplasminemic by copper deprivation. When the plasma ceruloplasmin level fell below 1% of normal, cell-to-plasma iron flow became sufficiently impaired to cause hypoferremia, even though total body iron stores were normal. When ceruloplasmin was administered to such animals, plasma iron increased immediately and continued to rise at a rate proportional to the logarithm of the ceruloplasmin dose. The administration of inorganic copper induced increases in plasma iron only after ceruloplasmin appeared in the circulation. Thus, ceruloplasmin appeared to be essential to the normal movement of iron from cells to plasma.
Why I Will Continue to Screen Prostate-Specific Antigen for Myself and Other Appropriate Men
Authors: David L. Keller
Journal: JAMA Internal Medicine (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
METRAZOL SHOCK TREATMENT
Authors: Abraham Myerson
Journal: JAMA (1942)

<h3>To the Editor:—</h3> In the discussion of the paper by Dr. Erich Liebert entitled "Spontaneous Convulsions Following Metrazol Treatment" (The Journal, January 10, p. 119), Dr. Roy R. Grinker of Chicago makes the following statement: At one time I indicated that, with metrazol, psychiatrists hardly waited for the patient to take his clothes off before he was shocked, and now we learn from Dr. Myerson that it is not necessary to hospitalize a patient, that one can shock him in one's office, keep him there for an hour or two and then return him home. This I consider extremely dangerous, since before long such easily applied therapy will be appropriated by the inexpert and used promiscuously and indiscriminately. Dr. Grinker is entirely mistaken when he states that I have advocated the use of shock treatment of any kind in an office, and I do not know what grounds he has
Goodbye and thanks
Authors: Des Spence
Journal: BMJ (2008)

After dominating the planet for aeons, the dinosaurs became extinct almost overnight. Various conspiracy theories circulate, from being wiped out by a huge meteorite strike to being nibbled to death by our small, arboreal ancestors. Full time doctors are likewise dying out in their droves. Their bodies can be found floating in swimming pools across Europe, sipping gin and tonics, and laughing about their index linked pensions. Despite primitive contracts, with only rough financial vegetation to sustain …
Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy
Authors: Richard L. Proia, Timothy Hla
Journal: Journal of Clinical Investigation (2015)

Membrane sphingolipids are metabolized to sphingosine-1-phosphate (S1P), a bioactive lipid mediator that regulates many processes in vertebrate development, physiology, and pathology. Once exported out of cells by cell-specific transporters, chaperone-bound S1P is spatially compartmentalized in the circulatory system. Extracellular S1P interacts with five GPCRs that are widely expressed and transduce intracellular signals to regulate cellular behavior, such as migration, adhesion, survival, and proliferation. While many organ systems are affected, S1P signaling is essential for vascular development, neurogenesis, and lymphocyte trafficking. Recently, a pharmacological S1P receptor antagonist has won approval to control autoimmune neuroinflammation in multiple sclerosis. The availability of pharmacological tools as well as mouse genetic models has revealed several physiological actions of S1P and begun to shed light on its pathological roles. The unique mode of signaling of this lysophospholipid mediator is providing novel opportunities for therapeutic intervention, with possibilities to target not only GPCRs but also transporters, metabolic enzymes, and chaperones.
Early bypass surgery increases risk of stroke
Authors: D. Josefson
Journal: BMJ (2001)

Patients who have a coronary artery bypass graft soon after experiencing unstable angina or non-Q wave myocardial infarcts face a higher risk of stroke than those who forgo the surgery or delay it, says a new study ( Circulation 2001;104:269-74).

The study suggested that physicians should rethink the advisability of early aggressive surgical revascularisation after heart attacks. Dr Lisa Cronin and colleagues from McMaster University in Ontario, …
Analysis of Gγ-158(C→T) polymorphism in hemoglobin E/β-thalassemia major in Southern China
Authors: Rong Rong Liu, Ming Yue Wang, Yong Rong Lai
Journal: Journal of Hematology & Oncology (2010)

Abstract Background The G γ-158(C→T) polymorphism plays important function in the clinical variability of HbE/β-thalassemia. There is little known about G γ-158(C→T) polymorphism in HbE/β-thalassemia major in Southern China. This study aimed to explore the association between HbE/β-thalassemia major and this polymorphism in Southern China. Methods and Results The frequency of the G γ-158(C→T) polymorphism has been evaluated in 32 patients with HbE/β-thalassemia major from Southern China. Further analysis of the G γ-158(C→T) polymorphism revealed the prominent frequency of this polymorphic pattern among HbE/β-thalassemia major patients (65.63%). The presence of this polymorphism was strongly correlated with the increase of HbF synthesis. Conclusions The frequency of the G γ-158(C→T) polymorphism was relatively high in Southern Chinese patients with HbE/β-thalassemia major, often accompanying with high production of HbF. This feature appears to be different with reports in other races and regions.
Post-treatment Efficacy Of House Dust Mites (HDM) Sublingual Immunotherapy (SLIT) Tablets In Adult Patients
Authors: P. Demoly, M. Worm, W. Fokkens, A. Tabar, H. Nguyen, O. De Beaumont, M. Mélac, A. Montagut, K. Bergmann
Journal: Journal of Allergy and Clinical Immunology (2011)
Evaluation of the prevalence of anti-wheat-, anti—flour dust-, and anti-alpha amylase-specific IgE antibodies in blood donors
Authors: R.E. Biagini, B.A. MacKenzie, D.L. Sammons, J.P. Smith, C.A.F. Striley, S.A. Robertson, J.A. Snawder
Journal: Journal of Allergy and Clinical Immunology (2003)
Opportunities for Targeted Therapies in Hepatocellular Carcinoma
Authors: Melanie B. Thomas, James L. Abbruzzese
Journal: Journal of Clinical Oncology (2005)

Hepatocellular cancer (HCC) is the fifth most common solid tumor worldwide, accounting for 500,000 new cases annually. Although less common in the United States, HCC is expected to increase in incidence over the next two decades largely because of the prevalence of hepatitis C virus infection. A majority of patients present with advanced disease and are not candidates for liver transplantation, surgical resection, or regional therapy. In 60% to 80% of patients with HCC, treatment is complicated by underlying liver cirrhosis and hepatic dysfunction. Systemic treatments are minimally effective, can have significant toxicity, and have not been shown to improve patient survival. New approaches targeting molecular abnormalities specific to HCC are needed to improve patient outcome. This review summarizes the state of knowledge of those key aspects of the molecular pathogenesis of HCC that may represent rational therapeutic targets in this disease. Relevant preclinical and clinical information on novel compounds directed toward abnormalities in HCC is reviewed.
A CASE OF MULTIPLE LARYNGOTRACHEAL STENOSIS.
Authors: THOS. HUBBARD
Journal: JAMA (1899)

Adventitious stenosis of the larynx or trachea is usually attributable to syphilis. Lesions of this character—ulceration, cicatrical tissue, formation of contractures—are rarely observed in childhood and adolescence. The case which I report has a somewhat obscure history both as regards constitutional and initial symptoms of the present condition, and there is, at worst, merely a vague suspicion of congenital syphilis based chiefly on pathologic probabilities and the questionable moral status of the parents, the mother being Spanish and at the present time being apart from her second husband. On the other hand, the evidences against systemic disease are: A healthy mother and sister, the father was healthy up to the time of having typhoid fever, with which he died, and the patient is of good morals, exhibits good vitality and has no active symptoms at present. The girl is now 20 years of age and her physical development is above
Arthroscopy and Patellar Chondropathy
Authors: H. Zollinger, P. Schmohl
Journal: Endoscopy (1980)

Arthroscopy has proved to be a reliable method to determine acute and chronic retropatellar damage to cartilaginous tissue. The discrepancy between clinical and radiological findings, subjective disorders, and the actual morphological changes, seem to make arthroscopy desirable in analysing an objective and documentable initial situation. Long-term examinations will have to show how reliable prognostic statements are, and how justifiable the operative or conservative measures indicated by arthroscopic examination can be.