tbuckley/cabot-search huggingface dataset:
Professors Not Professing
Authors: Catherine D. DeAngelis
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bio-assay of Human Serum Parathormone-like Activity.
Authors: Henry M. Lemon
Journal: Annals of Internal Medicine (1964)

s1 February 1964Bio-assay of Human Serum Parathormone-like Activity.Henry M. Lemon, M.D., F.A.C.P., H. T. Lynch, M.D., M. J. Henn, M.D., F.A.C.P.Henry M. Lemon, M.D., F.A.C.P.Search for more papers by this author, H. T. Lynch, M.D.Search for more papers by this author, M. J. Henn, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-331_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhite Swiss mice pretreated with 3.0 ml of CaCl2(16 mEq/liter) and MgCl2(8 mEq/liter) in 0.9% saline respond to bovine parathyroid extract by a twofold or greater increase in urinary milliequivalent phosphorus/milliequivalent calcium in 4 hours, which follows a linear dose-response up to 1 to 2 USP units per mouse. Human serum, 0.1 ml, usually induces some increase in phosphorus/calcium excretion by mise, which we believe represents circulating parathyroid hormone (PTH), since (1) A fourfold increase in activity has been demonstrated in canine thyroid-parathyroid venous plasma compared to simultaneously sampled peripheral plasma. Thyroxin is inert. (2) Calcium gluconate infusions... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Henry M. Lemon, M.D., F.A.C.P.; H. T. Lynch, M.D.; M. J. Henn, M.D., F.A.C.P.Affiliations: Omaha, Nebraska PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byENDOCRINOLOGICALLY ACTIVE MESENCHYMAL TUMORSPara-endocrine hypercalcemia in ovarian neoplasms.Report of mesonephroma with hypercalcemia and review of literatureCALCIUM METABOLISM AND CANCER 1 February 1964Volume 60, Issue 2_Part_1Page: 331-331KeywordsBlood plasmaCalciumExcretionParathyroidParathyroid hormoneSaline solutionsThyroidThyroxineUnited States pharmacopeia ePublished: 1 December 2008 Issue Published: 1 February 1964 PDF downloadLoading ...
Acute Sinusitis in Adults
Authors: Shih-Wei Lai, Kuan-Fu Liao
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Updated Hodgkins' disease. C. Advanced disease and special problems. Advances in chemotherapy
Authors: E. Frei
Journal: JAMA (1973)

Chemotherapy is employed as primary treatment for patients with disseminated (stages IIIB and IV) Hodgkin's disease. A number of agents or classes of agents are capable of producing an objective response in patients with Hodgkin's disease. These include the alkylating agents, the periwinkle alkaloids, ie, vincristine sulfate (Oncovin), and vinblastine sulfate (Velban), procarbazine hydrochloride (Natulan [Great Britain]; Matulane, comparable US product), carmustine (BCNU) [1,3, bis (2-chloroethyl)-1-nitrosourea], adriamycin, and the corticosteroids. The time-honored approach has been to employ single agents in sequence starting usually with an alkylating agent and progressing to vinblastine sulfate. An agent was employed until it was clear that response was not going to occur, or until relapse occurred following response, at which point the next agent in sequence was introduced. Basic therapeutic and clinical studies in the leukemias indicate that the therapeutic index can be improved by manipulation of such variables as dose schedules, duration of treatment,
Preventing Isoniazid Hepatotoxicity
Authors: THOMAS MOULDING
Journal: Annals of Internal Medicine (1976)

Comments1 September 1976Preventing Isoniazid HepatotoxicityTHOMAS MOULDING, M.D., F.A.C.P., MICHAEL ISEMAN, M.D., F.A.C.P., JOHN SBARBARO, M.D., F.C.C.P.THOMAS MOULDING, M.D., F.A.C.P.Search for more papers by this author, MICHAEL ISEMAN, M.D., F.A.C.P.Search for more papers by this author, JOHN SBARBARO, M.D., F.C.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-3-398_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The NIH Conference on isoniazid liver injury in the February issue (Ann Intern Med 84:181-192, 1976) presented an interesting observation that might be used to prevent isoniazid hepatotoxicity in humans. Specifically, it was noted that when a single dose of 300 mg/kg of isoniazid was given to rats, no hepatotoxicity occurred despite pretreatment with phenobarbital. By contrast, when 100 mg/kg was given every hour for six doses, diffuse single cell necrosis of the liver occurred. The lack of toxicity with a single dose of isoniazid was stated to be due to saturation of the enzyme acetyltransferase, so...References1. SBARBAROBARLOWCRAIG JPM: Intermittent chemotherapy for adults with tuberculosis. Am Rev Respir Dis 110:374-376, 1974 MedlineGoogle Scholar2. BLACKMITCHELLZIMMERMAN MJH: Isoniazid-associated hepatitis in 114 patients. Gastroenterology 69:289-302, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: THOMAS MOULDING, M.D., F.A.C.P.; MICHAEL ISEMAN, M.D., F.A.C.P.; JOHN SBARBARO, M.D., F.C.C.P.Affiliations: University of Colorado School of Medicine Denver, CO 80220 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntimycobacterial TherapyAntimycobacterial TherapyAntituberculous AgentsAntituberculous AgentsDrugs used in tuberculosis and leprosy 1 September 1976Volume 85, Issue 3Page: 398-399KeywordsEnzymesIsoniazidLiverNecrosisToxicity ePublished: 1 December 2008 Issue Published: 1 September 1976 PDF downloadLoading ...
Antibodies against synthetic oligopeptides deduced from the putative core gene for the diagnosis of hepatitis C virus infection
Authors: Hiroaki Okamoto, Fumio Tsuda, Atsuhiko Machida, Eisuke Munekata, Yoshihiro Akahane, Yoshiki Sugai, Kazuo Mashiko, Takehiro Mitsui, Takeshi Tanaka, Yuzo Miyakawa, Makoto Mayumi
Journal: Hepatology (1992)

Immunoassays were developed to detect antibodies against oligopeptides deduced from the putative core gene of hepatitis C virus, and their performances were compared with that of the commercial immunoassay for antibodies against the product of nonstructural regions of hepatitis C virus (anti-C100-3). A 19-mer oligopeptide (CP10) and a 36-mer oligopeptide (CP9) were chemically synthesized, which represented hydrophilic regions of the product of the hepatitis C virus core gene. They were used to capture corresponding antibodies, anti-CP10 and anti-CP9, by enzyme-linked immunosorbent assay in sera from patients with acute or chronic non-A, non-B liver disease and in blood donations. At the onset of acute non-A, non-B hepatitis, anti-CP10 was detected in 15 of 20 patients (75%), and anti-CP9 was detected in 14 patients (70%). This was more frequent than anti-C100-3, which was found in only 9 patients (45%). In 186 patients with chronic non-A, non-B liver disease, anti-CP9, anti-CP10 or both were detected in 170 patients (91%). This was more frequent than anti-C100-3, which was found in 138 patients (74%). Blood with anti-CP10 as the single serological marker for hepatitis C virus infection transmitted non-A, non-B hepatitis by needlestick exposure. In sera from 558 apparently healthy blood donors, anti-CP10 was detected in 55 donors (9.9%), anti-CP9 was detected in 26 donors (4.7%) and anti-C100-3 was detected in 7 donors (1.3%). Among sera positive by at least one test, 14 were found to contain hepatitis C virus RNA; 7 of them were negative for anti-C100-3 but positive for anti-CP10 and/or anti-CP9 in high titers. These results indicate that antibodies against antigenic determinants of the hepatitis C virus core would complement anti-C100-3 for the diagnosis of non-A, non-B liver disease and contribute toward further decreasing the incidence of posttransfusion non-A, non-B hepatitis. (HEPATOLOGY 1992;15:180-186).
John Alexander Forbes
Authors: L. Forbes
Journal: BMJ (2003)

Former professor of primary medical care Southampton University (b Aberdeen 1922; q Aberdeen 1951; MA, MD, FRCGP), died from lung cancer on 22 June 2003.​2003.




Figure 1




After active service in north Africa, Italy, and Palestine, John Forbes returned to Aberdeen in 1946, determined to read medicine. He was a general practitioner for 16 years in Bicester, researching and writing his MD in his spare time. In 1969 John was appointed senior lecturer at the newly forming Southampton Medical School—which took its first students in 1971—becoming professor of primary medical care in 1972. Determined to produce doctors who understood the social context of illness, he developed new ways of teaching medicine. One of these was the early medical contact scheme, in which general practitioners took first year students into patients' homes. He leaves a wife, June; four children; and five grandchildren.
Targeting Epstein-Barr Virus–Associated Lymphomas
Authors: Sarah Nikiforow, Ann S. LaCasce
Journal: Journal of Clinical Oncology (2014)

Article Tools UNDERSTANDING THE PATHWAY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2013.53.2994 Journal of Clinical Oncology - published online before print February 3, 2014 PMID: 24493729 Targeting Epstein-Barr Virus–Associated Lymphomas Sarah NikiforowxSarah NikiforowSearch for articles by this author , Ann S. LaCascexAnn S. LaCasceSearch for articles by this author Show More Dana-Farber Cancer Institute, Boston, MA https://doi.org/10.1200/JCO.2013.53.2994 First Page Full Text PDF Figures and Tables © 2014 by American Society of Clinical Oncology
Evaluation of Headache-Reply
Authors: Donald L. Myers
Journal: JAMA (1981)

In Reply.—  Computed axial tomography has proved to be a powerful tool in the noninvasive neurodiagnostic evaluation because of the superb diagnostic accuracy and minimal patient risk involved. Consequently, the CT scanner is inherently subject to excessive use. The advisability of restricting CT scanning in patients with headache to those having abnormalities in their neurological examination has been discussed as a means for lessening the economic burden.  Drs Ordia and Mark have posed several circumstances under which potentially hazardous intracranial lesions may be present without notable neurological abnormality on examination. Their comments are entirely appropriate and describe problems encountered in active clinical practice. Midline posterior fossa lesions causing hydrocephalus from fourth ventricular outflow obstruction, pinealomas, and giant aneurysms are other entities that may be present without obvious neurological signs. CT scanning may obviate the need for lumbar puncture in a patient suspected of having subarachnoid hemorrhage by documenting the presence
Long non-coding RNAs and control of gene expression in the immune system
Authors: Maninjay K. Atianand, Katherine A. Fitzgerald
Journal: Trends in Molecular Medicine (2014)

All cells of the immune system rely on a highly integrated and dynamic gene expression program that is controlled by both transcriptional and post-transcriptional mechanisms. Recently, non-coding RNAs, including long non-coding RNAs (lncRNAs), have emerged as important regulators of gene expression in diverse biological contexts. lncRNAs control gene expression in the nucleus by modulating transcription or via post-transcriptional mechanisms targeting the splicing, stability, or translation of mRNAs. Our knowledge of lncRNA biogenesis, their cell type-specific expression, and their versatile molecular functions is rapidly progressing in all areas of biology. We discuss here these exciting new regulators and highlight an emerging paradigm of lncRNA-mediated control of gene expression in the immune system.
The relationship between autoimmune markers and different clinical syndromes in autoimmune hepatitis
Authors: I G McFARLANE
Journal: Gut (1998)

Brain orexin (hypocretin) neurons are implicated in sleep-wake switching and reward-seeking, but their roles in rapid arousal dynamics and reward perception remain unclear. Here, cellspecific stimulation, deletion, and in vivo recordings revealed strong correlative and causal links between pupil dilation - a quantitative arousal marker - and orexin cell activity. Coding of arousal and reward was distributed across orexin cells, indicating that they specialize in rapid, multiplexed communication of momentary arousal and reward states.
877-6 Symptomatic patients have similar outcomes compared to asymptomatic patients after carotid artery stenting with emboli protection
Authors: Michael H Yen, David S Lee, Samir Kapadia, Ravish Sachar, Jakob Schneider, Mary Ellen Satava, Christopher T Bajzer, Deepak L Bhatt, Jay S Yadav
Journal: Journal of the American College of Cardiology (2004)
Surgery of the rheumatoid knee.
Authors: P J Abernethy
Journal: Annals of the Rheumatic Diseases (1990)

The knee is the most commonly affected major joint in rheumatoid arthritis.Fleming et al showed that one or both knees eventually become affected in 90% of patients, with unilateral involvement in 30-35%.'This com- pares with a 40% incidence of hip involvement in patients with rheumatoid arthritis.This high level of knee disease clearly has great significance in relation to the need for knee surgery.As a result it has become the most commonly replaced joint on the rheumatoid arthritis service at the Princess Margaret Rose Orthopaedic Hospital in Edinburgh.
Evaluation of abdominal ultrasonography mass screening for hepatocellular carcinoma in Taiwan
Authors: Yen-Po Yeh, Tsung-Hui Hu, Po-Yuan Cho, Hsiu-Hsi Chen, Amy Ming-Fang Yen, Sam Li-Sheng Chen, Sherry Yueh-Hsia Chiu, Jean Ching-Yuan Fann, Wei-Wen Su, Yi-Jen Fang, Shih-Tien Chen, Hsiao-Ching San, Hung-Pin Chen, Chao-Sheng Liao
Journal: Hepatology (2013)

Mass screening with abdominal ultrasonography (AUS) has been suggested as a tool to control adult hepatocellular carcinoma (HCC) in individuals, but its efficacy in reducing HCC mortality has never been demonstrated. This study aimed to assess the effectiveness of reducing HCC mortality by mass AUS screening for HCC based on a program designed and implemented in the Changhua Community-based Integrated Screening (CHCIS) program with an efficient invitation scheme guided by the risk score. We invited 11,114 (27.0%) of 41,219 eligible Taiwanese subjects between 45 and 69 years of age who resided in an HCC high-incidence area to attend a risk score-guided mass AUS screening between 2008 and 2010. The efficacy of reducing HCC mortality was estimated. Of the 8,962 AUS screening attendees (with an 80.6% attendance rate), a total of 16 confirmed HCC cases were identified through community-based ultrasonography screening. Among the 16 screen-detected HCC cases, only two died from HCC, indicating a favorable survival. The cumulative mortality due to HCC (per 100,000) was considerably lower in the invited AUS group (17.26) compared with the uninvited AUS group (42.87) and the historical control group (47.51), yielding age- and gender-adjusted relative mortality rates of 0.69 (95% confidence interval [CI]: 0.56-0.84) and 0.63 (95% CI: 0.52-0.77), respectively. Conclusion : The residents invited to community-based AUS screening for HCC, compared with those who were not invited, showed a reduction in HCC mortality by ˜31% among subjects aged 45-69 years who had not been included in the nationwide vaccination program against hepatitis B virus infection. (Hepatology 2014;59:1840–1849)
Observations of orthotopic liver transplantation in the pig.
Authors: R. Y. Calne, H. J. White, D. E. Yoffa, R. R. Maginn, R. M. Binns, J. R. Samuel, V. P. Molina
Journal: BMJ (1967)

certain of these changes occurred to a lesser degree in stress involution.The stress-involuted thymuses in our study showed
M14 Role of endobronchial ultrasound-guided transbronchial needle aspiration in diagnosis of isolated mediastinal lymphadenopathy (IML)
Authors: R Mogal, R Patel, D Mukherjee, B Yung
Journal: Thorax (2013)

<h3>Introduction and Objectives</h3> The recognition of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) as an important diagnostic modality has been increasing in recent years, particularly following establishment of its use in lung cancer. Mediastinoscopy is considered as the gold-standard investigation for isolated mediastinal lymphadenopathy (IML), despite the invasiveness of the procedure and need for general anaesthesia. We present a retrospective clinical data in a large tertiary centre for respiratory medicine to evaluate to the role of EBUS-TBNA in establishing a diagnosis of IML and therefore avoiding more invasive techniques such as mediastinoscopy. <h3>Methods</h3> Retrospective analysis identified 249 patients undergoing EBUS-TBNA between August 2009 and July 2013, of whom 72 were found to have IML. All patients had CT or PET-CT prior to undergoing EBUS-TBNA. In patients where EBUS-TBNA failed to produce diagnosis, they received clinical and radiological follow up for upto 6 to 12 months or were considered for mediastinoscopy as per clinical needs. <h3>Results</h3> Of the 72 patients, 50 were male and 22 were female. For all patients, histological diagnosis was unknown prior to EBUS-TBNA. Confirmed pathological diagnosis was gained in total of 27 patients including 17 cases of sarcoidosis, 8 cases of malignancies, 1 case of tuberculosis and 1 case of ectopic thyroid tissue. Of the 8 confirmed malignancies 2 were adenocarcinoma, 2 were non-small cell carcinoma,1 was squamous cell carcinoma,1 was metastatic prostate carcinoma,1 was metastatic breast carcinoma and 1 was Chronic Lymphoid Lukaemia (CLL). No diagnosis was achieved in 40 patients while sample was insufficient in 3 cases and 2 were false negative (bronchoalveolar carcinoma and sarcoidosis). In all 72 patients, no significant complications were reported. Of the 40 undiagnosed cases, 29 patients were followed up clinically and radiologically and discharged as appropriate while remaining 11 are still under follow up. No patient has been referred for mediastinoscopy. <h3>Conclusions</h3> Already established as a safe and minimally-invasive diagnostic technique in pulmonary medicine, EBUS-TBNA provides an alternative for diagnosis of patients presenting with IML. The increasingly successful use of EBUS-TBNA in place of mediastinoscopy and CT-guided biopsy undoubtedly merits further attention in the consideration of investigation of mediastinal lymphadenopathy.
GW25-e0865 Cardiac Stem Cell Transplantation Improve Electrophysiological Stability in Rats with Myocardial Infarction via Inhibition of TGF-β1 Pathway
Authors: Zheng Shaoxin, Wang Tong, Hou Jingying, Liang Peifen, Fang Yanling, Guo Tianzhu, Wang Jingfeng
Journal: Journal of the American College of Cardiology (2014)
BTS guidelines on CAP
Authors: I M Gould
Journal: Thorax (2002)

The new BTS guidelines on the management of community acquired pneumonia (CAP) in adults1 are welcome if they lead to improved diagnosis of pneumonia, better assessment of severity of illness, and thus more appropriate treatment according to clinical needs. It is widely accepted, however, that inappropriate implementation of the previous guideline contributed to large increases in unnecessary use of broad spectrum antibiotics with resultant increases in antibiotic resistance and Clostridium difficile infection. The authors acknowledge this, but the new guidelines seem likely to continue this unfortunate trend.

Firstly, there is no mention of the use of oral penicillin …