tbuckley/cabot-search huggingface dataset:
Management of Fibromyalgia
Authors: Lawrence J. Cohn
Journal: Annals of Internal Medicine (2000)

Letters20 June 2000Management of FibromyalgiaLawrence J. Cohn, MDLawrence J. Cohn, MDNew York, NY 10021 (Cohn)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-12-200006200-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The essence of a peer-reviewed journal is an unbiased, scientific appraisal of data, vetted by the editors and reviewers. Review articles with therapy recommendations should be held to a higher standard than reporting of scientific experiments is. Therefore, Leventhal's review on fibromyalgia (1) is deeply disturbing. The existence of a definite clinical disease is not the issue. The repeated recommendations for the use of tramadol are.In the review, the efficacy of tramadol in fibromyalgia is supported by five references (references 65 through 69). Only one is from a genuine peer-reviewed journal, and that is an abstract. ...Reference1. Leventhal LJ. Management of fibromyalgia. Ann Intern Med. 1999;131:850-8. LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: New York, NY 10021 (Cohn) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoManagement of Fibromyalgia Lawrence J. Leventhal Management of Fibromyalgia Lawrence J. Leventhal Management of Fibromyalgia Frederick Wolfe Management of Fibromyalgia Arthur Huppert Management of Fibromyalgia Norman Muilenburg Management of Fibromyalgia Hideto Akama Metrics Cited ByFibromyalgia 20 June 2000Volume 132, Issue 12Page: 1005KeywordsDrug addictionDrugsFibromyalgia Issue Published: 20 June 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Cyclobenzaprine in Intractable Pain Syndromes With Muscle Spasm
Authors: Burnell R. Brown
Journal: JAMA (1978)

The effectiveness of cyclobenzaprine hydrochloride, a new tricyclic skeletal muscle relaxant, was shown in patients with long-term intractable pain of cervical and lumbar origin aggravated by skeletal muscle spasm and tenderness. The investigation was double-blind and randomized, comparing cyclobenzaprine hydrochloride (10 mg three times a day) with diazepam (5 mg three times a day) and with placebo. After two weeks of treatment, the 16 patients in the cyclobenzaprine group showed an overall improvement in pain variables as did the 16 patients in the diazepam group. No serious adverse reactions to cyclobenzaprine were observed in the study. However, dry mouth due to cyclobenzaprine's anticholinergic action and mild degrees of drowsiness were encountered more often than with diazepam or placebo.
Treatment of Behcet Disease with Pentoxifylline
Authors: Vedat Hamuryudan
Journal: Annals of Internal Medicine (1997)

Letters15 March 1997Treatment of Behcet Disease with PentoxifyllineVedat Hamuryudan, MD, Yilmaz Ozyazgan, MD, and Hasan Yazici, MDVedat Hamuryudan, MDUniversity of Istanbul, Istanbul, TurkeySearch for more papers by this author, Yilmaz Ozyazgan, MDUniversity of Istanbul, Istanbul, TurkeySearch for more papers by this author, and Hasan Yazici, MDUniversity of Istanbul, Istanbul, TurkeySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-6-199703150-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:We are responsible for the care of almost 3000 patients with Behcet disease and read with great interest the report by Yasui and colleagues on successful treatment of this disease with pentoxifylline [1].Behcet disease usually runs a course of exacerbations and remissions that gradually abate with time. Exacerbations in the eye cause a sharp decline in visual acuity that almost always improves as the attack subsides. Thus, studies testing treatment for the disease should not allow each patient to be his or her own control (as Yasui and colleagues' study did). Such a method results in ...REFERENCE1. Yasui K, Ohta K, Kobayashi M, Aizawa T, Komiyama A. Successful treatment of Behcet disease with pentoxifylline. Ann Intern Med. 1996; 124:891-3. Google Scholar Author, Article, and Disclosure InformationAuthors: Vedat Hamuryudan, MD; Yilmaz Ozyazgan, MD; Hasan Yazici, MDAffiliations: University of Istanbul, Istanbul, Turkey PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGenetics and immunodysfunction underlying Behçet’s disease and immunomodulant treatment approachesIL-2/IL-2 antibody immune complex regulates HSV-induced inflammation through induction of IL-2 receptor alpha, beta, and gamma in a mouse modelMiscellaneous treatments, I: sulfasalazine and pentoxifylline: unapproved uses, dosages, or indicationsOral disorders: unapproved treatments or indications11The opinions expressed herein are solely those of the investigators and do not necessarily reflect the opinions of the institutions with which they are associated.Maladie de Behçet 15 March 1997Volume 126, Issue 6 Page: 494 Keywords Colchicine Neutrophils Visual acuity ePublished: 15 August 2000 Issue Published: 15 March 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
P1-07-12: Assessment of Real World HER2 Status by Immunohistochemistry (IHC) and Fluorescence In Situ Hybridization (FISH) in Breast Cancers: Comparison with HERmark®, a Validated Quantitative Measure of HER2 Protein Expression.
Authors: W Huang, A Paquet, S Sivaraman, R Pesano, L Goodman, T Sherwood, Y Lie, J Hickey, C Walworth, M Haddad, S Anderson, M Bates, J Weidler
Journal: Cancer Research (2011)

Abstract Background: Accurate assessment of the HER2 status is critical in determining appropriate therapy for patients with invasive breast cancer. ASCO/CAP HER2 testing guidelines caution that up to 20% of routine HER2 testing by IHC/FISH may be unreliable (Wolff et al. JCO 2007;25:118). The HERmark assay is a novel quantitative HER2 protein measurement for determining HER2 status in breast cancer. Central HER2 testing showed high concordance (96-98%) with HERmark for positive and negative categories when equivocal subsets were excluded (Huang et al. Am J Clin Pathol 2010;134:303; Joensuu et al, 2008 SABCS, abstract 2071). In this study, we examined concordance between HERmark and routine HER2 testing by IHC and FISH from “real world” formalin-fixed, paraffin-embedded (FFPE) breast cancers submitted commercially for HERmark testing. Methods: 717 HERmark results on FFPE breast cancers tested from 2008 to 2010 and corresponding HER2 IHC/FISH results were reviewed. The IHC and FISH results, per pathology reports submitted at the time of HERmark testing, were compared to HERmark categorical (negative, equivocal, positive) results. Results: 590 (419) samples had IHC (FISH) and HERmark results available. Of these cases, 92% (94%) were either negative or equivocal by IHC (FISH). The HERmark testing reported 33% HERmark negative, 33% HERmark equivocal and 34% HERmark positive. Comparisons of HER2 status by IHC and FISH vs. HERmark are detailed in Table 1. 19% of cases classified as IHC 0 or 1+ were positive by HERmark; 35% classified as FISH negative were HERmark positive. Of the 158 triple negative cases by IHC/FISH (ER, PR and HER2 negative, data not shown), 38 (24%) were reclassified as HER2 positive by HERmark. Conclusions: Higher than expected discordance between HER2 IHC/FISH and the HERmark assay was observed in this study compared with central HER2 testing of prior study cohorts. Selection bias may have impacted these results as ≥ 92% of cases submitted for HERmark testing were either equivocal or negative by routine HER2 IHC/FISH. Central HER2 FISH retesting of these samples will be performed and compared with HERmark results to further evaluate the discordance observed in this analysis. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P1-07-12.
Day-care Quality and Quantity Become Challenges for Parents, Politicians, and Medical Researchers
Authors: Jody W. Zylke
Journal: JAMA (1988)

A FEW YEARS ago, day care was rarely discussed on Capitol Hill. But by last fall, it had become a major issue in the presidential campaign. There seems to be no doubt in political circles that the question of day care is not one of "if" but of "how" and "how much." Unlike the politicians, day care was heatedly discussed among psychologists a few years ago. Today, although disagreements remain, consensus has been reached on some issues. <h3>Quality and Stability</h3> Experts agree that children can do well with high-quality, stable supplemental care. Researchers are still debating the significance of existing research data, while uniformly calling for additional data to sort out the myriad of factors that have an impact on an infant's development. Little debate exists over supplemental care for children over ages 2 1/2 to 3 years old. A long experience with nursery and preschools has provided ample evidence
Quinidine and Lupus-Like Syndrome
Authors: LONNIE B. HANAUER
Journal: Annals of Internal Medicine (1973)

Letters, Comments, and Corrections1 February 1973Quinidine and Lupus-Like SyndromeLONNIE B. HANAUER, M.D., F.A.C.P.LONNIE B. HANAUER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-78-2-308_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their review of recent advances in connective tissue diseases (Ann Intern Med 77:455-464, 1972), Drs. Wallace, Diamond, and Kaplan note that quinidine has "been added to the list" of drugs capable of inducing a lupus erythematosus-like syndrome.The case report referred to (Postgraduate Med J 46:729-731, 1970) describes a 73-year-old woman who, after 17 months of quinidine therapy, developed a lupus-like rash and pancytopenia. No LE cells were found, and the antinuclear factor (ANF) was "weakly positive. "Quinidine therapy was continued, a small dose of prednisone was added, and subsequent symptoms were minimal.The diagnosis of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byQuinidine☆QuinidineDrug Action, Reaction, and Interaction 1 February 1973Volume 78, Issue 2Page: 308-308KeywordsAtrial natriuretic peptidesConnective tissue diseasesDrugsNeutrophilsRashes ePublished: 1 December 2008 Issue Published: 1 February 1973 PDF downloadLoading ...
Chief inspector criticises prison medical service
Authors: S. Spencer
Journal: BMJ (1990)

self perpetuating bias: the higher the impact factor of a journal, the more authors will try to publish in it, and because it has a high impact factor it will be considered more prestigious and authoritative, and will be cited more often.This bias compounds the built in bias in Science Citation Index data in which "the selection policy is deliberately slanted towards material most widely used and with highest impact."7Despite known reservations to judging the importance ofa journal by this method, such as self citation, "parochialism," language biases, etc,8"these are lesser evils compared with the far reaching consequences of judging an author by citation performance of the journals in which he or she published.Lately we have become aware of a greater understanding of the shortcomings of the impact factor of journals, and administrators are turning more to the citation performance of individuals.This is undeniably more personalised than the impact factor of a journal but is not free of flaws.For instance, only the first author appears in the citation index, and a search by "cited references" for a particular author will not reflect the true contribution of all the authors.We are deliberately ignoring technical errors such as misspellings, wrong initials, etc.Finally, there is a considerable time lag between the publication of an original paper, the publication of an article citing it, and its appearance in the Science Citation Index's annual bibliometric analyses.We hope that all these factors are taken into account when using citation analyses for judging a person's performance or potential and in making decisions on academic advancement, funding, or tenure.
The Potential Pathogenic Role of Complement in Dengue Hemorrhagic Shock Syndrome
Authors: Viktor A. Bokisch, Franklin H. Top, Philip K. Russell, Frank J. Dixon, Hans J. Müller-Eberhard
Journal: New England Journal of Medicine (1973)

In Bangkok, Thailand, 49 of 127 patients with dengue hemorrhagic fever experienced shock. The concentration of nine complement proteins measured in serial serum samples decreased during shock with the exception of C9. C3 and C5 were reduced to 20 to 40 per cent of normal in severe cases. Decrease of plasma fibrinogen, appearance of fibrinogen split products and thrombocytopenia indicated occurence of intravascular coagulation. Metabolic studies of C3 and C1q, performed on 24 patients, indicated a markedly enhanced fractional catabolic rate especially during shock. These results support the concept that activation of complement can constitute a major factor in the pathogenesis of dengue hemorrhagic shock. (N Engl J Med 289:996–1000, 1973)
Megaloblastic Anemia Possibly Induced by Triamterene in Patients with Alcoholic Cirrhosis
Authors: FRED L. LIEBERMAN
Journal: Annals of Internal Medicine (1968)

Two patients are described who appeared to develop megaloblastic anemia during therapy with triamterene and hydrochlorothiazide, and both had low serum folate levels. One of these two patients was critically ill with this complication but survived when triamterene was stopped and folic and folinic acids were administered. Because triamterene has been shown to be a folic acid antagonist in vitro, we conclude that this drug may precipitate megaloblastic anemia in alcoholic cirrhosis by inhibiting the utilization of folic acid in the presence of low stores of folic acid.
COMPARATIVE EVALUATION OF GATED SPECT THALLIUM CARDIAC IMAGING USING STANDARD AND SHORTENED ACQUISITION PROTOCOLS
Authors: A. D. Ross, T. D. Payne, C. J. Branstetter, S. M. Devers, C. M. Carr, S. J. Durham, J. J. Nemec, J. J. Pippin
Journal: Clinical Nuclear Medicine (1997)

Ross, A. D.; Payne, T. D.; Branstetter, C. J.; Devers, S. M.; Carr, C. M.; Durham, S. J.; Nemec, J. J.; Pippin, J. J. Author Information
Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion
Authors: Yanfeng Wang, Liang Zhao, Aae Suzuki, Lurong Lian, Sang H. Min, Ziqian Wang, Rustem I. Litvinov, Timothy J. Stalker, Tadayuki Yago, Arkadiusz G. Klopocki, David W. Schmidtke, Helen Yin, John K. Choi, Rodger P. McEver, John W. Weisel, John H. Hartwig, Charles S. Abrams
Journal: Blood (2013)
Alterations in angiotensin II receptor mediated signal transduction shortly after coronary artery constriction in the rat
Authors: H. Huang, P. Li, C. V Hamby, K. Reiss, L. G Meggs, P. Anversa
Journal: Cardiovascular Research (1994)

The aim of the study was to determine the effect of coronary artery constriction on the density of angiotensin II receptors and on the effector responses coupled with these receptors on myocytes one week after surgical induction of coronary artery stenosis in rats.After induction of coronary artery stenosis and following the estimation of global cardiac performance, myocytes were enzymatically dissociated and radioligand binding studies were performed. In addition, the isotonic contractile performance, cytosolic calcium transients, and angiotensin II stimulated inositol phosphate generation in myocytes were measured in the presence and absence of the angiotensin II receptor subtype antagonist losartan.After documenting left ventricular failure and right ventricular dysfunction, the expression and density of angiotensin II receptors in left ventricular myocytes were evaluated and found to be increased 3.1-fold and 4.1-fold, respectively. Corresponding increases in right ventricular myocytes were 3.6-fold and 4.5-fold. In contrast, the quantity of the regulatory protein Gq alpha was not altered in either ventricle. Angiotensin II did not increase the generation of total inositol phosphates in left and right ventricular myocytes at maximum stimulation. However, the threshold for the formation of inositol phosphates was lowered in left ventricular myocytes of coronary narrowed rats. Measurements of single cell mechanics indicated that angiotensin II stimulation markedly improved the depression in myocyte function biventricularly. This inotropic effect was coupled with the restoration of cytosolic calcium.The upregulation of angiotensin II receptors on myocytes in this model of global ischaemia may be a compensatory mechanism ameliorating myocyte contractility in an attempt to sustain ventricular pump function.
Management of renal colic
Authors: M. Bultitude, J. Rees
Journal: BMJ (2012)

#### Summary points

Urinary stone disease is increasingly prevalent, with a lifetime risk of about 12% in men and 6% in women.1 Age of onset of a first stone episode for men rises from their 20s and peaks at age 40-60 years, with an incidence of three cases per 1000 population per year. Women appear to peak a little younger in their late 20s. The male to female ratio is narrowing, with one study showing a reduction from 1.7:1 to 1.3:1 over a five year period.2 Presentation varies according to geographical and seasonal factors, with higher incidences in warmer climates and during the summer months.3

This review includes the latest information from meta-analyses, systematic reviews, randomised trials, current guidelines, and other peer reviewed evidence to provide a background on presentation, investigation, and medical and surgical management of patients with renal colic.

#### Sources and selection criteria

We performed a PubMed search to identify peer reviewed original articles, meta-analyses, and reviews using the search terms “renal colic” and “ureteric stone”. We also reviewed national and international guidelines, and the Cochrane Collaboration and clinical evidence databases. We considered only papers written in English, with the emphasis on more recent articles if available or if we deemed the scientific validity to be …
Aryl Hydrocarbon Receptor–Independent Toxicity of Weathered Crude Oil during Fish Development
Authors: John P. Incardona, Mark G. Carls, Hiroki Teraoka, Catherine A. Sloan, Tracy K. Collier, Nathaniel L. Scholz
Journal: Environmental Health Perspectives (2005)

Polycyclic aromatic hydrocarbons (PAHs), derived largely from fossil fuels and their combustion, are pervasive contaminants in rivers, lakes, and nearshore marine habitats. Studies after the Exxon Valdez oil spill demonstrated that fish embryos exposed to low levels of PAHs in weathered crude oil develop a syndrome of edema and craniofacial and body axis defects. Although mechanisms leading to these defects are poorly understood, it is widely held that PAH toxicity is linked to aryl hydrocarbon receptor (AhR) binding and cytochrome P450 1A (CYP1A) induction. Using zebrafish embryos, we show that the weathered crude oil syndrome is distinct from the well-characterized AhR-dependent effects of dioxin toxicity. Blockade of AhR pathway components with antisense morpholino oligonucleotides demonstrated that the key developmental defects induced by weathered crude oil exposure are mediated by low-molecular-weight tricyclic PAHs through AhR-independent disruption of cardiovascular function and morphogenesis. These findings have multiple implications for the assessment of PAH impacts on coastal habitats.
Effect of increased serum sulphydryl content on titre of rheumatoid factor.
Authors: I A Jaffe, P Merryman
Journal: Annals of the Rheumatic Diseases (1968)

Article abstract-We describe the clinical case and MRI findings of a patient with acquired immune deficiency syndrome and pathologically confirmed cytomegalovirus encephalitis. Prevalent brainstem and cerebellar signs together with almost exclusive involvement as seen on MRI of posterior fossa structures at the onset of the symptoms were the main features of our case. <b>NEUROLOGY 1997;48: </b> 529-530
Attenuated Cardiac Sympathetic Responsiveness During Dynamic Exercise in Patients With Heart Failure
Authors: Bengt Rundqvist, Graeme Eisenhofer, Mikael Elam, Peter Friberg
Journal: Circulation (1997)

Background Cardiac norepinephrine (NE) spillover is increased in patients with chronic heart failure. This elevation is partly due to augmented NE release but also to reduced capacity for cardiac NE removal processes. In patients with mild to moderate heart failure, it is not known whether the described alteration in cardiac sympathetic function also affects cardiac NE spillover during intense sympathetic activation and whether other organs respond in proportion to the heart. Methods and Results Twenty-two patients with heart failure and 15 age-matched healthy subjects were studied. Whole-body and regional (NE) spillovers from the heart and kidneys were assessed at baseline and during supine cycling exercise (10 minutes) with the use of steady-state infusions of tritiated NE (isotope dilution). Cardiac performance was evaluated by means of catheterization of the right side of the heart. Cardiac NE spillover was higher ( P &lt;.05) at baseline in the patient group than in healthy subjects, whereas renal and whole-body NE spillovers were similar between the study groups. During exercise, cardiac NE spillover increased 13-fold ( P &lt;.05) in healthy subjects but only 5-fold ( P &lt;.05) in the cardiac failure group, the latter reaching a lower peak value ( P &lt;.05). In contrast, there was no difference between the study groups in either renal or whole-body NE spillover responsiveness to exercise. Conclusions Patients with mild to moderate heart failure demonstrated a selective attenuation of cardiac sympathetic responsiveness during dynamic exercise. This attenuation may convey reduced inotropic and chronotropic support to the failing heart.