tbuckley/cabot-search huggingface dataset:
TREATMENT OF GONORRHEA IN THE MALE.
Authors: W. FRANK GLENN
Journal: JAMA (1906)

In the treatment of gonorrhea we must recognize two or three important facts and govern our treatment accordingly, otherwise we will find it well nigh impossible to complete a cure at all. <h3>First.</h3> —Gonorrhea is caused by the presence of the gonococci, which set up a rather violent inflammation. <h3>Second.</h3> —The inflammation begins just within the meatus urinarius and extends, if left without proper treatment, rapidly into the deep urethra. Recognizing these two important factors, the rational treatment of gonorrhea is to begin treatment at the earliest possible moment, and to commence at once with local applications, by injection of a remedy that will kill, or at least inhibit the development of the gonococci, and at the same time heal and soothe the inflamed membrane. Many high in authority advise doing practically nothing until the acute symptoms have subsided, which usually takes from two to three weeks. They advise bland
Toxemia of pregnancy in sheep: a clinical, physiological, and pathological study
Authors: Thomas F. Ferris, Peter B. Herdson, Michael S. Dunnill, M. Radcliffe Lee
Journal: Journal of Clinical Investigation (1969)

Toxemia was induced in 13 of 20 pregnant ewes by the stress of a change in environment and food deprivation late in pregnancy. Of the toxemic ewes, eight developed prominent neurological findings with convulsions, motor weakness, and blindness, whereas five ewes developed azotemia without neurological signs. Proteinuria and azotemia occurred in all but one of the toxemic animals. Seven animals did not develop clinical or laboratory evidence of toxemia. Hypertension did not occur with the onset of toxemia but all toxemic animals showed glomerular changes by light and electron microscopy. These abnormalities, which were similar to those seen in human preeclampsia, included endothelial cell swelling, focal reduplication of the basement membrane, and fusion of the epithelial cell foot processes. The toxemia could not be attributed to changes in hematocrit, plasma glucose, Na, Cl, CO(2), K, Ca, fibrinogen, arterial pH, lactate, or pyruvate concentrations. Cardiac output fell only in ewes with prominent neurological signs. Plasma renin rose strikingly in animals developing toxemia, without change in substrate concentration. In contrast to human and other species, sheep uterus and amniotic fluid contained no detectable quantities of renin. Thus in response to stress the pregnant ewe develops a toxemia which in the absence of hypertension has clinical and pathological similarities to human preeclampsia.
The Use of Transcriptional Profiling to Improve Personalized Diagnosis and Management of Cutaneous T-cell Lymphoma (CTCL)
Authors: Ivan V. Litvinov, Elena Netchiporouk, Brendan Cordeiro, Marc-André Doré, Linda Moreau, Kevin Pehr, Martin Gilbert, Youwen Zhou, Denis Sasseville, Thomas S. Kupper
Journal: Clinical Cancer Research (2015)

Although many patients with mycosis fungoides presenting with stage I disease enjoy an indolent disease course and normal life expectancy, about 15% to 20% of them progress to higher stages and most ultimately succumb to their disease. Currently, it is not possible to predict which patients will progress and which patients will have a stable disease. Previously, we conducted microarray analyses with RT-PCR validation of gene expression in biopsy specimens from 60 patients with stage I-IV cutaneous T-cell lymphoma (CTCL), identified three distinct clusters based upon transcription profile, and correlated our molecular findings with 6 years of clinical follow-up.We test by RT-PCR within our prediction model the expression of about 240 genes that were previously reported to play an important role in CTCL carcinogenesis. We further extend the clinical follow-up of our patients to 11 years. We compare the expression of selected genes between mycosis fungoides/Sézary syndrome and benign inflammatory dermatoses that often mimic this cancer.Our findings demonstrate that 52 of the about 240 genes can be classified into cluster 1-3 expression patterns and such expression is consistent with their suggested biologic roles. Moreover, we determined that 17 genes (CCL18, CCL26, FYB, T3JAM, MMP12, LEF1, LCK, ITK, GNLY, IL2RA, IL26, IL22, CCR4, GTSF1, SYCP1, STAT5A, and TOX) are able to both identify patients who are at risk of progression and also distinguish mycosis fungoides/Sézary syndrome from benign mimickers.This study, combined with other gene expression analyses, prepares the foundation for the development of personalized molecular approach toward diagnosis and treatment of CTCL.
Frequency of Surveillance for Barrett Esophagus—Reply
Authors: Risa B. Burns, Tom Delbanco
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Faculty Practice Plans
Authors: Gordon K. MacLeod
Journal: JAMA (1986)

In 1910, the Flexner report signaled the end of commercialism in American medical schools, only to have it reappear in 1931. Between 1960 and 1985, access to federal, state, and private-sector funds paid to medical service plans in all 127 medical schools led to almost a 20-fold increase in faculty practice plan (FPPs)—from six to 118. All 127 US medical schools were surveyed. Wide swings in federal funding policies left medical schools with a defective management model, particularly for FPPs. Disposition of collected revenues, the role of for-profit FPPs, the personally lucrative nature of FPPs, an unwieldy number of fairly autonomous departments, ineffective governance, and hostile opposition from other parts of the university have raised questions of conflict of interest and accountability. Some 75 years after the Flexner report, a thorough evaluation of the effects of commercialism on medical education once again appears to be warranted. (<i>JAMA</i>1986;256:58-62)
Engagement, Peer Production, and the Learning Healthcare System
Authors: Michael Seid, Peter A. Margolis, Lisa Opipari-Arrigan
Journal: JAMA Pediatrics (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
PERIPROCEDURAL MYOCARDIAL INFARCTION AND HIGH ON-TREATMENT PLATELET REACTIVITY
Authors: Michael Angelo Gaglia, Rebecca Torguson, Zhenyi Xue, Rajbabu Pakala, Manuel A. Gonzalez, Itsik Ben-Dor, Gabriel Maluenda, Michael Mahmoudi, Gabriel Sardi, Kohei Wakabayashi, Rafael Romaguera, Ana Carnicero, William O. Suddath, Kenneth M. Kent, Lowell F. Satler, Augusto D. Pichard, Ron Waksman
Journal: Journal of the American College of Cardiology (2011)
Methicillin-resistant Staphylococcus aureus in a general intensive care unit
Authors: D S Thompson
Journal: Journal of the Royal Society of Medicine (2004)

Methicillin-resistant Staphylococcus aureus (MRSA) has presented special problems in intensive care units (ICUs) because of the difficulties in implementing infection control measures. The prevalence and rate of acquisition of MRSA were studied over thirty months in a nine-bed ICU. Nasal and groin swabs were taken on admission and then weekly, and other cultures as clinically indicated. Of 1361 admissions 119 were MRSA-positive on arrival. 21 cases had been identified before admission and the remainder were detected by screening; in 57 the positive result was known only after discharge. Of the 1242 admissions initially negative 68 acquired MRSA while in the ICU. The ICU had no known MRSA-positive patients on 185 (20.3%) of 914 days, the longest sequence being 17 days. Positive patients occupied 1387 (16.9%) of the 8226 available bed days. Length of stay predicted the risk of acquiring MRSA. Estimated from patients who completed each weekly screening cycle, the risk was 7.5% per week in the first week and 20.3% per week thereafter. The risk was not influenced by initial APACHE II score, the use of haemofiltration, or the number of MRSA-positive patients in the unit. The data suggest that a further 38 of those discharged between weekly screenings acquired MRSA, giving an incidence of 8.5%. MRSA was grown from blood in 17 patients, and from sputum in 53 (ICU-acquired in 18% and 47%). This study suggests that nearly 10% of admissions to a general ICU will be MRSA-positive, of whom only half will be identified before discharge. With standard prevention the risk of previously negative patients acquiring MRSA approximates to 1% per day in the first week and 3% per day thereafter, with nearly one-fifth progressing to bacteraemia; one-half will have MRSA in sputum. Patients with longer stays constitute a high-risk minority for whom additional measures such as decontamination with oropharyngeal and enteral vancomycin should be considered.
Combination and Sequential Therapy for Osteoporosis
Authors: Robert P. Heaney, Robert R. Recker
Journal: New England Journal of Medicine (2005)

For an investment approaching $1 billion, a pharmaceutical manufacturer may obtain approval from regulatory agencies to market a specific dose of a given medication for the treatment or prevention of a particular disorder. Such approval emphasizes and is based largely on the demonstration of simple efficacy and safety. Often little is known, not just about unanticipated side effects of the drug, much in the news of late, but also about such fundamental and critically important issues as the optimal duration of treatment; the effects, if any, of interactions with other agents affecting the same organs or tissues; or optimal sequencing . . .
Abstract 3463: The role of Atg13 in response to radiotherapy in cervical cancer cells
Authors: Frank Roossink, Aniek Boers, Bea Wisman, Ed Schuuring, Ate van der Zee, Steven de Jong
Journal: Cancer Research (2012)

Abstract Introduction The role of autophagy protecting cancer cells against anti-cancer therapy, especially via the Beclin-1 axis, has become more clear. In cervical cancer, functionality of the Beclin-1 axis can be questioned, since promoter methylation and silencing of two components of this axis, C13ORF18 (Rubicon-like) and DAPK, is frequently observed. The involvement of another autophagy pathway, the ULK1 axis is less well studied in this tumor type. The ULK1 axis, consisting of ULK1, Atg13 and FIP200 is under control of mTOR. Here, we investigated the role of the essential component of the ULK1 complex, Atg13 in the response to (chemo)radiation in cervical cancer. Methods and Results Using immunohistochemistry we first analyzed expression of Atg13 in a large cohort of 375 pretreatment tissue samples of advantaged stage cervical cancer patients primarily treated with (chemo)radiation. Positive expression of Atg13 was more frequently observed in adenocarcinoma, known to have a poor response to chemoradiation, compared to squamous carcinoma (75% versus 56 % positive tumors, p&amp;lt; 0.03). Transient overexpression of GFP-tagged Atg13 in HEK293T kidney cells increased radiotherapy resistance (1.5-2 fold). Western blot showed that Atg13 was expressed in several cervical cancer cell lines, including the adenocarcinoma model HeLa. Downregulation of Atg13 expression with siRNA, resulted in a 2-fold increase in radiotherapy sensitivity in HeLa cells as determined with clonogenic assays. In HeLa-GFP-LC3 cells, we found that irradiation caused a strong increase in LC-3 containing autophagosomes, which co-localized with Atg13. The autophagy inhibitor bafilomycin A1 blocks the conversion of autophagosomes into autolysosomes. Bafilomycin A1 treatment indeed resulted in an accumulation of radiation-induced autophagosomes, demonstrating that autophagy was occurring after irradiation. In addition, HeLa cells were sensitized to irradiation, when autophagy was inhibited with bafilomycin A1. These results were confirmed using the less specific autophagy inhibitor 3-methyladenine and the autophagy inducer rapamycin (an mTOR inhibitor). Conclusion We showed that the Atg13 expression is related to the presence of cervical adenocarcinoma. Our in-vitro results indicate that the autophagic ULK1 pathway plays an important role in protecting cervical cancer cells to irradiation. Thus, inhibition of autophagy may be an interesting strategy to sensitize cervical adenocarcinoma to radiotherapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3463. doi:1538-7445.AM2012-3463
A Case of Bilateral, Completely Latent Adrenal Tumor and Concurrent Nephritis with Changes in the Circulatory System and Retinitis
Authors: F. Frankel
Journal: CA A Cancer Journal for Clinicians (1984)

CA: A Cancer Journal for Clinicians publishes information about the prevention, early detection, and treatment of cancer, as well as nutrition, palliative care, survivorship, and additional topics of interest related to cancer care.
Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations
Authors: Kirsten M. Kloepfer, Wai Ming Lee, Tressa E. Pappas, Theresa J. Kang, Rose F. Vrtis, Michael D. Evans, Ronald E. Gangnon, Yury A. Bochkov, Daniel J. Jackson, Robert F. Lemanske, James E. Gern
Journal: Journal of Allergy and Clinical Immunology (2014)
Review of the Abortion Act
Authors: A. O. Diver
Journal: BMJ (1971)

<h3>Abstract</h3> Carboxysomes are self-assembled bacterial microcompartments that facilitate carbon assimilation by co-localizing the enzymes of CO<sub>2</sub> fixation within a protein shell. These microcompartments can be highly heterogeneous in their composition and filling, so measuring the mass and loading of an individual carboxysome would allow for better characterization of its assembly and function. To enable detailed and extended characterizations of single nanoparticles in solution, we recently demonstrated an improved Interferometric Scattering Anti-Brownian ELectrokinetic (ISABEL) trap, which tracks the position of a single nanoparticle via its scattering of a near-infrared beam and applies feedback to counteract its Brownian motion. Importantly, the scattering signal can be related to the mass of nanoscale proteinaceous objects, whose refractive indices are well-characterized. We calibrate single-particle scattering cross-section measurements in the ISABEL trap and determine individual carboxysome masses in the 50-400 MDa range by analyzing their scattering cross-sections with a core-shell model. We further investigate carboxysome loading by combining mass measurements with simultaneous fluorescence reporting from labeled internal components. This method may be extended to other biological objects, such as viruses or extracellular vesicles, and can be combined with orthogonal fluorescence reporters to achieve precise physical and chemical characterization of individual nanoscale biological objects. <h3>TOC Graphic</h3>
Congenital Heart Defect Devices
Authors: Bernard A. Schwetz
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Clinical and Biochemical Studies in Patients with Functioning Islet Cell Tumors.
Authors: J. B. Field
Journal: Annals of Internal Medicine (1962)

s1 April 1962Clinical and Biochemical Studies in Patients with Functioning Islet Cell Tumors.J. B. Field, M.D.J. B. Field, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-674_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFunctioning islet cell tumors frequently pose diagnostic problems. Of four patients recently studied, one was admitted to the neurosurgical service for temporal lobectomy forpetit malseizures, and another had been under intermittent psychiatric treatment for three years. They all fulfilled Whipple's triad when they were appropriately tested. The one patient tested with I.V. orinase gave a positive response. Two of the patients developed hypoglycemia after ingestion of 150 mg/kg L-leucine, but not after isoleucine, valine, or other amino acids. In one of these patients, hypoglycemia was produced by oral isovaleric acid but not by β-OH, β-CHsu>3 glutaric acid,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, Md. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 674-674KeywordsAmino acidsEpileptic seizuresHypoglycemiaIngestionLeucineLobectomyPatients Issue Published: 1 April 1962 PDF DownloadLoading ...
Effects of evening primrose oil in rheumatoid arthritis.
Authors: D F Horrobin
Journal: Annals of the Rheumatic Diseases (1989)

A 64 year old woman presented with redness in the left eye and pain in the temples of one week's duration.Ophthalmological examination showed injected conjunc- tiva: a hypopyon on the left side with cells in the anterior chamber.Fundal examination showed peripheral in- creased white fluffy lesions suggestive of inflammatory choroidal effusions.With a diagnosis of anterior and posterior uveitis treatment was started with topical steroids and mydriatic drugs, to which she had a good ocular response.She continued to have headaches, however.
STUDIES ON THE COMPLEMENT FIXATION ANTIGENS OF INFLUENZA VIRUSES TYPES A AND B
Authors: Maria Wiener, Werner Henle, Gertrude Henle
Journal: The Journal of Experimental Medicine (1946)

Two types of specific particles can be obtained from allantoic fluid preparations of influenza A and B virus. The larger particle which possesses all the attributes of the virus and which shows a sedimentation constant of about 600 S was compared with the smaller component (30 S) by complement fixation technic. The 30 S component can be differentiated from the 600 S particle by the patterns of the optimal antigen-antibody relationships and by cross-absorption of the sera with the two particles. Some of the 30 S-type antigen can be demonstrated in higher concentrations of the 600 S particles by the use of sera containing only anti-30 S; i.e., sera carefully absorbed with 600 S component. Also, upon sonic vibration of the 600 S particle, serologically active material was released which behaved in every respect like the 30 S antigen. The response of human beings to these antigens was found to vary. Antibodies to the 30 S component developed in the majority of subjects exposed to active virus either under epidemic or experimental conditions, but only rarely following vaccination with three different vaccines. In selecting sera without 30 S antibodies a fairly close correlation between the antibody titers obtained by inhibition of hemagglutination and complement fixation with the 600 S component was obtained. The presence of 30 S antibodies prevented such a correlation. The reaction with the 30 S antigen may be of value in the diagnosis and study of the epidemiology of influenza.
Comparison of functional balance training and wobble board training on subjects with functional ankle instability
Authors: Zafar Azeem, Vikas Dhawan, Kalpna Zutshi
Journal: British Journal of Sports Medicine (2010)

Ankle instability is the most common cause of lower extremity dysfunction in physically active individuals. In spite of various treatment options available to therapists and trainers like ankle braces, taping, prophylactic ankle disc training programmes, recurrence rate of ankle sprains has been very high. Efficacy and comparison of functional balance training programme and wobble board training programme on static and dynamic measures of postural control are still confounding. The study (pretest and post-test experimental design) was aimed to determine the efficacy and comparison of functional balance training programme and wobble board training programme on subjects with functional ankle instability where measures of static and dynamic postural control (using single leg stance test and star excursion balance test) were measured following 4 weeks of balance training programme. Both the training displayed statistically non-significant changes at the end of 4 weeks of balance training following functional ankle instability. Clinical improvements in static and dynamic measures of postural control as observed provided an insight into the introduction of an alternative form of functional balance training programme for athletes with a history of recurrent ankle sprains. The presentation will be aimed to spread awareness about the significance of balance training programme in the prevention of ankle injuries in sports and importance of inculcating functional patterns of balance training in the athletic training regimens.