Treatment of α-1-Antitrypsin Deficiency, Massive Edema, and Panniculitis with α-1 Protease Inhibitor
Authors: Nancy Lee Furey
Journal: Annals of Internal Medicine (1996)

Letters15 October 1996Treatment of α-1-Antitrypsin Deficiency, Massive Edema, and Panniculitis with α-1 Protease InhibitorNancy Lee Furey, MD, Robert S. Golden, MD, and Steven R. Potts, DONancy Lee Furey, MDNorthwestern University Medical School, Chicago, IL 60611, Robert S. Golden, MDNorthwestern University Medical School, Chicago, IL 60611, and Steven R. Potts, DONorthwestern University Medical School, Chicago, IL 60611Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-8-199610150-00027 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:A 62-year-old woman presented with red nodules on her thigh and an acute respiratory infection for which she was taking clemastine and phenylpropanolamine. Similar lesions had developed 25 years earlier in the 34th week of a pregnancy. At that time, the patient was treated with a sulfonamide but developed angioedema. She then received intramuscular penicillin, but the skin lesions enlarged and ulcerated. A cesarean section was done at 38 weeks' gestation without complications. After parturition, the patient was treated with prednisone, 60 mg/d; this therapy was discontinued when the ulcerations rapidly enlarged. After several months, the skin ...References1. Balk E, Bronsveld W, Makkes Van Der Deyl JA, Kwee WS, Thus LG. Alpha-1-antitrypsin deficiency with vascular leakage syndrome and panniculitis. Neth J Med. 1982; 25:138-41. Google Scholar2. Smith KC, Pittelkow MR, Su WP. Panniculitis associated with severe α-1-antitrypsin deficiency. Arch Dermatol. 1987; 123:1655-61. Google Scholar Author, Article, and Disclosure InformationAffiliations: Northwestern University Medical School, Chicago, IL 60611 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAlpha-1 Antitrypsin Deficiency and PregnancyRare manifestations of AATDManaging panniculitis in alpha-1 antitrypsin deficiency: Systematic review of evidence behind treatmentNeutrophilic panniculitis associated with alpha-1-antitrypsin deficiency: an updateMisfolding and Polymerisation of Alpha1-Antitrypsin: Conformational Pathology and Therapeutic TargetingAlpha-1-Antitrypsin-MangelUnusual Acute Sequelae of α 1 -Antitrypsin DeficiencyAlpha-1-antitrypsin deficiency panniculitis presenting with severe anasarca, pulmonary embolus and hypogammaglobulinaemiaThe design of a new truncated and engineered alpha1-antitrypsin based on theoretical studies: an antiprotease therapeutics for pulmonary diseasesInflammatory diseases of the subcutaneous fatThe discovery of α1-antitrypsin and its role in health and diseaseMetabolic panniculitis: alpha-1 antitrypsin deficiency panniculitis and pancreatic panniculitisAlpha-1-Antitrypsin Deficiency PanniculitisPanniculitis in Alpha-1 Antitrypsin Deficiency?1-Antitrypsin deficiency presenting with panniculitis and incidental discovery of chronic obstructive pulmonary diseaseAlpha-1-antitrypsin associated panniculitis: The MS variantalpha1-Antitrypsin deficiency panniculitis (phenotype PiZZ) precipitated postpartum and successfully treated with dapsoneAmerican Thoracic Society/European Respiratory Society StatementPanniculitis secondary to extravasation of clarithromycin in a patient with alpha1-antitrypsin deficiency (phenotype PiZ)Successful Treatment of Idiopathic Febrile Panniculitis (Weber-Christian Disease) with Thalidomide in a Patient Having Failed Multiple Other Medical TherapiesKrankheiten des subkutanen FettgewebesPanniculitis. Part II. Mostly lobular panniculitisPanniculitis due to α 1 ‐antitrypsin deficiency induced by cryosurgeryα 1 -antitrypsin deficiency 15 October 1996Volume 125, Issue 8Page: 699KeywordsEdemaLesionsPhenotypesPregnancyProtease inhibitorsSepsisShockSulfonamideUlcersUpper respiratory tract infections Issue Published: 15 October 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...