Goodpasture's Syndrome in Indentical Twins
Authors: A. J. F. D'apice, Priscilla Kincaid-Smith, G. J. Becker, M. G. Loughhead, J. W. Freeman, J. M. Sands
Journal: Annals of Internal Medicine (1978)

Brief Reports1 January 1978Goodpasture's Syndrome in Indentical TwinsA. J. F. D'APICE, F.R.A.C.P., PRISCILLA KINCAID-SMITH, F.R.C.P., F.R.A.C.P., G. J. BECKER, M.R.A.C.P., M. G. LOUGHHEAD, F.R.A.C.P., J. W. FREEMAN, F.R.A.C.P., J. M. SANDS, F.R.A.C.P.A. J. F. D'APICE, F.R.A.C.P., PRISCILLA KINCAID-SMITH, F.R.C.P., F.R.A.C.P., G. J. BECKER, M.R.A.C.P., M. G. LOUGHHEAD, F.R.A.C.P., J. W. FREEMAN, F.R.A.C.P., J. M. SANDS, F.R.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-1-61 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptGoodpasture's syndrome is an autoimmune disease of unknown aetiology. Viral and streptococcal infections (1, 2) and exposure to hydrocarbon fumes (3) have been suggested as possible causal agents. Familial occurrence has been reported in only two instances (4, 5).In our study of identical twins with Goodpasture's syndrome, the following methods were used. Renal biopsies: percutaneous renal biopsies were processed and examined by light microscopy and fluorescence microscopy using fluorescein-conjugated antisera against IgG, IgM, IgA, C3, and fibrinogen. Plasma exchange: 4-litre plasma exchanges were done on an Aminco Celltrifuge.Identical twin sisters, aged 18, presented 6 weeks apart with haemoptysis...References1. PASTERNACK E, LINDER E, and KUHLBÄCK B: Glomerulonephritis with initial pulmonary haemorrhage. Acta Med Scand 177:601-605, 1965 CrossrefMedlineGoogle Scholar2. BENOIT F, RULON D, THEIL G, DOOLAN P, and WATTEN R: Goodpasture's syndrome: a clinico-pathologic entity. Am J Med 37:424-444, 1964 CrossrefMedlineGoogle Scholar3. BEIRNE G: Goodpasture's syndrome and exposure to solvents. JAMA 222:1555, 1972 CrossrefMedlineGoogle Scholar4. MADDOCK R, STEVENS L, REEMTSMA K, and BLOOMER H: Goodpasture's syndrome: cessation of pulmonary haemorrhage after bilateral nephrectomy. Ann Intern Med 67:1259-1264, 1967 LinkGoogle Scholar5. GOSSAIN V, GERSTEIN A, and JANES A: Goodpasture's syndrome: a familial occurrence. Am Rev Respir Dis 105:621-624, 1972 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: A. J. F. D'APICE, F.R.A.C.P.; PRISCILLA KINCAID-SMITH, F.R.C.P., F.R.A.C.P.; G. J. BECKER, M.R.A.C.P.; M. G. LOUGHHEAD, F.R.A.C.P.; J. W. FREEMAN, F.R.A.C.P.; J. M. SANDS, F.R.A.C.P.Affiliations: Launceston General Hospital Launceston, Tasmainia Australia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEnfermedad antimembrana basal glomerular en hermanos no gemelos con HLA idénticoAnti-glomerular basement membrane disease in HLA-identical non-twin siblingsTOXIC EFFECTS OF SOLVENT EXPOSURECutaneous VasculitisClustering of Anti-GBM Disease: Clues to an Environmental Trigger?TOXIC EFFECTS OF SOLVENT EXPOSUREImmune and Inflammatory Glomerular DiseasesNephrotoxicity of organic solvents from skin exposureTwin studies in autoimmune disease: Genetics, gender and environmentGoodpasture SyndromeImmune-Mediated and Other Glomerular DiseasesNephrotoxicity of organic solvents: biomarkers for early detectionIndustrial Solvents and Kidney DiseaseOUTCOMES IN PATIENTS WITH GOODPASTURE'S SYNDROME AND HYDROCARBON EXPOSUREPathogenesis: immunogenetic factorsFamilial occurrence of systemic vasculitis and rapidly progressive glomerulonephritisPULMONARY MANIFESTATIONS OF GOODPASTURE'S SYNDROMEGoodpasture's SyndromeOrganic Solvents and the KidneyLe syndrome de Goodpasture: rôle d'un facteur épidémiologique ? 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