tbuckley/cabot-search huggingface dataset:
Kidney Donors and Protein Intakes
Authors: LESLIE L. ROCHER
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 September 1987Kidney Donors and Protein IntakesLESLIE L. ROCHER, M.D., RICHARD D. SWARTZ, M.D.LESLIE L. ROCHER, M.D.Search for more papers by this author, RICHARD D. SWARTZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-2-427_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Bay and Hebert (1) suggest that all living renal donors be advised to restrict protein intake to 1 g/kg body weight after nephrectomy in order to prevent possible progression of renal insufficiency. We believe that such a regimen is unnecessarily restrictive and do not recommend such a course to our renal donors. In the largest study to date examining the role of dietary intake, Anderson and colleagues (2) found no correlation between protein consumption after unilateral nephrectomy and urinary protein excretion or level of renal function. Also, whereas it is well recognized that urinary protein excretion is...References1. BAYHEBERT WL. The living donor in kidney transplantation. Ann Intern Med. 1987;106:719-27. LinkGoogle Scholar2. ANDERSONVELOSAFROHNERT CJP. The risks of unilateral nephrectomy: status of kidney donors 10 to 20 years postoperatively. Mayo Clin Proc. 1985;60:367-74. CrossrefMedlineGoogle Scholar3. MILLERSUTHANTHIRANRIGGIO IMR. Impact of renal donation: long-term clinical and biochemical follow-up of living donors in a single center. Am J Med. 1985;79:201-8. CrossrefMedlineGoogle Scholar4. VINCENTIAMENDKAYSEN FWG. Long-term renal function in kidney donors: sustained compensatory hyperfiltration with no adverse effects. Transplantation. 1983;36:626-9. CrossrefMedlineGoogle Scholar5. HAKIMGOLDSZERBRENNER RRB. Hypertension and proteinuria: long-term sequelae of uninephrectomy in humans. Kidney Int. 1984;25:930-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Michigan Medical Center Ann Arbor, MI 48109 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1987Volume 107, Issue 3Page: 427-427KeywordsBody weightExcretionKidneysNephrectomyProteins Issue Published: 1 September 1987 PDF DownloadLoading ...
Body Temperature Control in Anaesthesia, Surgery and Intensive Care
Authors: E. H. Flewellen
Journal: JAMA (1981)

The goal of this book is to "attempt to provide a rational basis for monitoring body temperature in clinical practice and to bring together scattered information on body temperature changes, induced and spontaneous, that can occur during anesthesia, surgery and intensive care." This book, written for the clinical practitioner, achieves that goal. Chapter 1 considers basic physiological mechanisms regulating control of body temperature. A concise, well-organized review is presented with emphasis on the effects of alteration in temperature on various organ systems. Methods of measuring body temperature are the subject of chapter 2. A brief review considers the various types of thermometers available to the clinician and mean body temperature and temperature-measuring sites. In chapter 3, the author discusses drugs and body temperature, and their interaction, with emphasis on agents commonly employed in the perioperative period. Chapter 4 is confined to a review of the malignant hyperthermia (MH) syndrome and
Initial Clinical Experience With Regadenoson, a Novel Selective A2AAgonist for Pharmacologic Stress Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging
Authors: Robert C. Hendel, Timothy M. Bateman, Manuel D. Cerqueira, Ami E. Iskandrian, Jeffrey A. Leppo, Brent Blackburn, John J. Mahmarian
Journal: Journal of the American College of Cardiology (2005)
Malnutrition in childhood in the tropics.
Authors: C Gopalan
Journal: BMJ (1967)

Of the many causes of ill-health among children of the tropics malnutrition is undoubtedly the most important. Apart from its direct effects on health, malnutrition also exerts an indirect effect by diminishing resistance to infectious diseases. The infant and child mortality rates in tropical countries are high. In India, according to the latest census figures, while infants and children under the age of 5 years constitute 16.5% of the total population, deaths within this age group account for 40% of the total deaths in the country. Infant and toddler mortality rates in some of the tropical countries are shown in Table I. A curious reflection of such high mortality in infancy and childhood is that in contrast with the situation in Europe the average expectation of life in tropical countries is actually higher at the age of 5 years than at birth. These data indicate the magnitude of ill-health among infants and children in tropical countries.
Strong leadership is needed to steer NHS through planned changes, conference hears
Authors: A. McGauran
Journal: BMJ (2011)

Healthcare in England is facing a very difficult moment similar to its “big transition” when the 2001 NHS Plan introduced targets on waiting times for hospital treatment, the former NHS chief executive, Nigel Crisp, has said.

Chairing a conference on leadership and the NHS reforms, Lord Crisp, who was chief executive of the NHS in England from 2000 to 2006, said, “Like then, it feels very uncertain, but there are glimmers of hope.” He said his own view is that the Health and Social Care Bill now in front of the House of Lords is “deeply flawed.”

Summarising speakers’ themes, Lord Crisp asked whether patients …
A Micro-Ribonucleic Acid Signature Associated With Recovery From Assist Device Support in 2 Groups of Patients With Severe Heart Failure
Authors: Ravi Ramani, Deborah Vela, Ana Segura, Dennis McNamara, Bonnie Lemster, Vishnupriya Samarendra, Robert Kormos, Yoshiya Toyoda, Christian Bermudez, O.H. Frazier, Christine S. Moravec, John Gorcsan, Heinrich Taegtmeyer, Charles F. McTiernan
Journal: Journal of the American College of Cardiology (2011)
Trend for US patients to seek health information from media and internet is stalling
Authors: B. Roehr
Journal: BMJ (2011)

Patients in the United States were less likely to seek health information from sources other than their doctor in 2010 than in 2007, concludes a new survey.

Only half (50%) of the 17 000 people who participated in the telephone survey said they had sought out such information over the past 12 months, down from 56% in 2007, says the report of the survey, released on 23 November by the Center for Studying Health System Change in Washington, DC.

The 2007 sample had looked to the internet (31%), print media such as books, magazines, and newspapers (33%), and friends and relatives (31%) in …
The Surgical Council and Basic Surgical Examination
Authors: Robert A. Chase
Journal: JAMA (1971)

The Millis<sup>1</sup>and Coggeshall<sup>2</sup>reports, and the statement of the Committee on Graduate Training adopted by the regents of the American College of Surgeons in 1961,<sup>3</sup>encouraged development of innovative programs by the surgical boards and residency review committees. Last year the American Surgical Association formally urged the specialty boards to stimulate selected institutions to experiment with flexible and imaginative programs of graduate education (Report of Committee on Graduate Education, 1969). A number of boards have responded and others already had studies underway to assess present programs and new means of measuring the quality of the emerging specialists.<sup>4,5</sup>Some specialty boards, excited by the progress being made by others, were aware of the predictable virtues of open interdisciplinary cooperative effort. The useful purpose served by specialty development has become self-evident, but now there is a growing recognition of the dependency of specialists upon one another where
Top-down influences in the interactive alignment model: The power of the situation model
Authors: Tessa Warren, Keith Rayner
Journal: Behavioral and Brain Sciences (2004)

Pickering & Garrod's (P&G's) model is an innovative and important step in the study of naturalistic language. However, the simplicity of its mechanisms for dialogue coordination may be overstated and the hypothesized direct priming channel between interlocutors' situation models is questionable. A complete specification of the model will require more investigation of the role of top-down inhibition among representations.
DISAPPEARANCE OF PAINFUL PHANTOM LIMBS AFTER ELECTRIC SHOCK TREATMENT
Authors: J. E. PISETSKY
Journal: American Journal of Psychiatry (1946)

A 55-year-old male with an involutional psychosis precipitated by the traumatic loss of both legs with very painful phantom limbs was treated with electric shock. An improvement in the psychosis and a disappearance of the painful phantom limbs resulted. The mechanisms involved were discussed and relations to the causalgic state intimated.
Government targets on obesity remain a challenge, says spending watchdog
Authors: J. Wise
Journal: BMJ (2012)

Achieving the government’s targets on obesity will be a challenge, says a memorandum from the public spending watchdog.1

In October 2011 the government published its plans for tackling obesity, which set out two national ambitions to be achieved by 2020: a decrease in the level of excess weight among all adults and a sustained downward trend in the level of excess weight in children.2 

The plan was heavily criticised because it focused only on individual responsibility and failed to tackle the influence of the food and drinks industry. The government’s strategy is to work with the industry to reduce fat, sugar, and salt levels through “responsibility deals.”3

The National Audit Office was asked by MPs on the Public Accounts Committee to summarise the activities that have been launched so far. The memorandum …
Interleukin-5–producing CD4<sup>+</sup> T Cells Play a Pivotal Role in Aeroallergen-induced Eosinophilia, Bronchial Hyperreactivity, and Lung Damage in Mice
Authors: SIMON P. HOGAN, AULIKKI KOSKINEN, KLAUS I. MATTHAEI, IAN G. YOUNG, PAUL S. FOSTER
Journal: American Journal of Respiratory and Critical Care Medicine (1998)

Although activated CD4+ T cells have been implicated in the pathogenesis of asthma, the direct contribution of this leukocyte to the induction of aeroallergen-induced bronchial hyperreactivity and lung damage is unknown. In the present investigation, we have used a model of allergic airways inflammation, which displays certain phenotypic characteristics of late-phase asthmatic responses, together with interleukin-5–deficient (IL-5− / −) mice and donor antigen–specific CD4+ TH2-type cells to obtain unequivocal evidence for a role of this T lymphocyte in the pathophysiology of allergic airways inflammation. Antigen-primed CD4+ T cells and CD4− cells (CD4+-depleted population) were purified from the spleens of ovalbumin (OVA)-sensitized wild-type mice and adoptively transferred to OVA-sensitized and nonsensitized IL-5− / − mice. In vitro stimulation of the purified cell populations with OVA resulted in the secretion of IL-4 and IL-5, but not interferon- γ , from the CD4+ T cells, indicating that they were of the TH2 type. In contrast, interferon- γ , but not IL-4 and IL-5, was produced by the CD4− T cells. The CD4+ TH2-type cells (but not the CD4− cells) reconstituted aeroallergen (OVA)-induced blood and airways eosinophilia, lung damage, and airways hyperreactivity to β -methacholine in IL-5− / − mice. The reconstitution did not require prior sensitization of the mice, but it did not occur if they were aerosolized with saline instead of OVA. The circulating levels of OVA-specific -IgE and -IgG1 were not significantly altered by the adoptive transfer of either cell population. These investigations establish that IL-5–secreting CD4+ TH2-type cells play a pivotal role in generating blood and airways eosinophilia and in the subsequent development of bronchial hyperreactivity and lung damage that occurs in response to aeroallergens.
Interferon γ Enhances the Effectiveness of Tumor Necrosis Factor-Related Apoptosis–Inducing Ligand Receptor Agonists in a Xenograft Model of Ewing’s Sarcoma
Authors: Melinda S. Merchant, Xuezhong Yang, Fraia Melchionda, Maria Romero, Ruth Klein, Carol J. Thiele, Maria Tsokos, H. Udo Kontny, Crystal L. Mackall
Journal: Cancer Research (2004)

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces selective apoptosis in a variety of tumors, including most cell lines derived from Ewing's sarcoma family of tumors, an aggressive sarcoma that afflicts children and young adults. To determine the in vivo efficacy of TRAIL receptor agonists in Ewing's sarcoma family of tumors, mice with orthotopic xenografts were treated with anti-TRAIL-R2 monoclonal antibody or TRAIL/Apo2L in a model that can identify effects on both primary tumors and metastases. Administration of either agonist slowed tumor growth in 60% of animals and induced durable remissions in 11 to 19% but did not alter the incidence of metastatic disease. Response rates were not improved by concurrent doxorubicin treatment. Cells recovered from both TRAIL receptor agonist-treated and nontreated tumors were found to be resistant to TRAIL-induced death in vitro unless pretreated with interferon (IFN) gamma. This resistance coincided with a selective down-regulation of TRAIL receptor expression on tumor cells. In vivo treatment with IFNgamma increased tumor expression of TRAIL receptors and caspase 8, but did not increase the antitumor effect of TRAIL receptor agonists on primary tumors. However, IFNgamma treatment alone or in combination with a TRAIL receptor agonist significantly decreased the incidence of metastatic disease and the combination of TRAIL receptor agonist therapy with IFNgamma-mediated impressive effects on both primary tumors and metastatic disease. These data demonstrate that in vivo growth favors TRAIL resistance but that TRAIL receptor agonists are active in Ewing's sarcoma family of tumors and that the combination of TRAIL receptor agonists with IFNgamma is a potent regimen in this disease capable of controlling both primary and metastatic tumors.
Extended-Release Acetaminophen Overdose
Authors: Edward W. Cetaruk
Journal: JAMA (1996)

<h3>To the Editor.</h3> —There were 102 619 cases of ingestion of acetaminophen-containing products, including 100 deaths, reported in the United States in 1994.<sup>1</sup>Management of acute acetaminophen overdose is guided by the Rumack-Matthew nomogram, which assumes acetaminophen absorption in acute overdose is complete by 4 hours after ingestion.<sup>2</sup>In August 1994, McNeil Pharmaceuticals (Fort Washington, Pa) introduced Tylenol Extended Relief, the first extended-release formulation of acetaminophen available in the United States. Patients presenting after overdose with extended release (ER) acetaminophen (Tylenol ER) which contains 325 mg of immediate-release acetaminophen and 325 mg of extended-release acetaminophen per tablet, pose a dilemma because the kinetics of acetaminophen ER in overdose are unknown, and it is not known whether physicians can rely on the nomogram to facilitate treatment. Douglas et al<sup>3</sup>found no difference in time to peak concentration between acetaminophen ER and immediate-release acetaminophen in volunteers who ingested 75
Antihypertensive Therapy After Acute Ischemic Stroke—Reply
Authors: Jiang He, Yonghong Zhang, Jing Chen
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Partial Stapedectomy
Authors: J. V. D. Hough
Journal: JAMA (1964)

Experiences related here were obtained while utilizing the partial stapedectomy technique for stapedial ankylosis in over 2,000 cases. This procedure allows for removal of the pathologic portion of the footplate and normal reconstruction of mucous membrane and endosteum at the oval window. It utilizes the posterior crus as a functioning ossicle. Except in unusual circumstances, prosthetic devices and tissue grafts were found to be unnecessary. This technique has given excellent long-term results in a large number of patients. In over 90% of the cases reported the air-bone gap has closed to within 10 decibels, and in 65% of the cases, the air-bone gap was overclosed. Although some patients have been followed as long as seven years, there has been threshold regression of 10 decibels or more from the point of highest postoperative gain in only 1.5% of cases. Results reported recommend this technique as a step toward a more physiologic solution to the problem of stapedial ankylosis.
THE PATHOLOGY OF SPONTANEOUS AND INDUCED SUBCUTANEOUS NODULES IN RHEUMATIC FEVER 1
Authors: John R. Mote, Benedict F. Massell, T. Duckett Jones
Journal: Journal of Clinical Investigation (1937)

The purpose of this report is, first, to present a composite histological picture of subcutaneous nodules of rheumatic fever as obtained from a re- view of the literature; second, to attempt a pathological description on the basis of their known clinical age; and third, to describe the structure of a number of artificially induced nodules and compare them with spontaneously occurring nod- ules in rheumatic fever subjects.The production of these induced nodules and their clinical simi- larity to spontaneous nodules is the subject of the previous report (1).Since the descriptions of subcutaneous rheu- matic nodules found in the literature are very conflicting, it is desirable to summarize the available information to determine if the wide variations of structure are consistent with the findings which we propose to present.In the review of these reports, it is surprising that the descriptions are in most instances limited to single nodules re- moved at death.Only the more adequate de- scriptions will be quoted. LITERATUREBarlow and Warner (2) in 1881 described the sub- cutaneous nodule as "consisting of small masses of loose fibrous bundles, sometimes very vascular."Hirschsprung (3) reported that nodules consisted of " connective tissue rich in cells similar to granulation tissue with necro- biosis."Cavafy (4) described two nodules, " a small one consisted of young actively growing fibrous tissue cells with much intercellular tissue," and a "larger one had much looser structure though consisting undoubtedly of fibrous tissue.Strands of fibers were separated widely by edema and cellular infiltration. . . .Both nodules were very vascular, and the small arteries were enormously thickened in the inner coat so as to obliterate the lumen of some of the vessels.Many of them showed only proliferation of the endothelium."Later he (5) described in addition " a peculiar reticular tissue with strikingly rectangular meshes . . . ,in some parts this pecular substance was fibrinous."Money (6) and Parker (7) very briefly described several nodules but added no further 1 The expenses of this study have been defrayed by a grant from the Commonwealth Fund.1. Present less than 1 month ........
Classical and Follicular Variant Papillary Thyroid Carcinoma: Comparison of Clinical, Ultrasonographical, Cytological, and Histopathological Features in 444 Patients
Authors: Didem Ozdemir, Reyhan Ersoy, Neslihan Cuhaci, Dilek Arpaci, Eren P. Ersoy, Birol Korukluoglu, Gulnur Guler, Bekir Cakir
Journal: Endocrine Pathology (2011)
Risk factors for severe sepsis in community-onset bacteraemic urinary tract infection: Impact of antimicrobial resistance in a large hospitalised cohort
Authors: Evelyn Shaw, Natividad Benito, Jesús Rodríguez-Baño, Belén Padilla, Vicente Pintado, Esther Calbo, MªAngeles Pallarés, Mónica Gozalo, Patricia Ruiz-Garbajosa, Juan Pablo Horcajada, J. Gómez, E. Cercenado, E. Bunshow, C. Sánchez-Carrillo, M. Xercavins, M. Riera, B. Mirelis, R. Gamallo, L. Martínez, M.C. Fariñas, M. de Cueto, A. Pascual
Journal: Journal of Infection (2014)
Effect of hepatitis C virus treatment in fibrosis progression rate (FPR) and time to cirrhosis (TTC) in patients co-infected with human immunodeficiency virus: A paired liver biopsy study
Authors: Maribel Rodríguez-Torres, José F. Rodríguez-Orengo, Carlos F. Ríos-Bedoya, Alberto Fernández-Carbia, Acisclo M. Marxuach-Cuétara, Abimael López-Torres, Josselyn Jiménez-Rivera
Journal: Journal of Hepatology (2007)
Direct effects of hydralazine on cardiac contractile function, haemodynamics, and myocardial energetics in isolated myocardium
Authors: S. V RENDIG, L. D SEGEL, E. A AMSTERDAM
Journal: Cardiovascular Research (1988)

Journal Article Direct effects of hydralazine on cardiac contractile function, haemodynamics, and myocardial energetics in isolated myocardium Get access STEPHEN V RENDIG, STEPHEN V RENDIG From the Division of Cardiovascular Medicine, University of California Davis, Sacramento, California, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar LEIGH D SEGEL, LEIGH D SEGEL From the Division of Cardiovascular Medicine, University of California Davis, Sacramento, California, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar EZRA A AMSTERDAM EZRA A AMSTERDAM From the Division of Cardiovascular Medicine, University of California Davis, Sacramento, California, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 22, Issue 5, May 1988, Pages 322–328, https://doi.org/10.1093/cvr/22.5.322 Published: 01 May 1988 Article history Received: 09 November 1987 Accepted: 30 November 1987 Published: 01 May 1988
Methotrexate-induced epidermal necrosis
Authors: P.V. HARRISON
Journal: British Journal of Dermatology (1987)

A patient with erythrodermic psoriasis is described who developed epidermal necrosis due to methotrcxate. Concurrent salicylate administration and borderline renal failure interfered with methotrexate elimination, leading to an elcvated plasma methotrexate concentration 36 h aftcr the methotrexate administration. Although the epidermal necrosis is sometimes thought to be idiosyncratic, the present case suggcsts that it may be a dose‐related problem.