tbuckley/cabot-search huggingface dataset:
Emergency Cardiovascular Services
Authors: ALFRED L. ARONSON
Journal: Annals of Internal Medicine (1976)

Editorial Notes1 August 1976Emergency Cardiovascular ServicesALFRED L. ARONSON, M.D.ALFRED L. ARONSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-2-253 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDespite the enormous sums expended each year in the United States to support coronary-artery angiographic studies, bypass graft operations, and hospital intensive cardiac care units, the major human cost of coronary heart disease, sudden unexpected death, remains high. Do we have the right economic and clinical priorities?More than 180 000 sudden cardiac deaths occur per year in the United States in victims under the age of 68, who die before they reach a hospital offering cardiac care. Mortality from primary cardiac dysrhythmias associated with myocardial infarction has been substantially reduced through recent advances in cardiac care. Convincing evidence supports... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Connecticut-Mount Sinai Hospital Hartford, Connecticut PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1976Volume 85, Issue 2Page: 253-254KeywordsArrhythmiaCardiac care unitCoronary heart diseaseLongitudinal studiesMortalityMyocardial infarctionSudden cardiac death Issue Published: 1 August 1976 PDF DownloadLoading ...
CD23 Exhibits Negative Regulatory Effects on Allergic Sensitization and Airway Hyperresponsiveness
Authors: ANGELA HACZKU, KATSUYUKI TAKEDA, ECKARD HAMELMANN, JOAN LOADER, ANTHONY JOETHAM, IMRE REDAI, CHARLES G. IRVIN, JAMES J. LEE, HITOSHI KIKUTANI, DANIEL CONRAD, ERWIN W. GELFAND
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

The effects of an anti-CD23 monoclonal antibody (B3B4) in CD23-deficient and CD23-overexpressing mice were compared in a murine model of allergic sensitization. After sensitization and challenge with OA, mice developed increased serum levels of OA-specific IgE and IgG1 with airway eosinophilia and AHR when compared with nonsensitized animals. Anti-CD23 treatment was studied under two protocols: 10-d OA aerosol exposure and intraperitoneal sensitization followed by aerosol challenge. In both protocols anti-CD23 significantly reduced IgE and IgG1 levels, abolished eosinophilia, and normalized AHR in BALB/c and wild-type CD23+ / + mice but not in CD23− / − mice. These changes were associated with increases in IFN- γ and decreases in IL-4 production, suggesting that CD23 binding may affect not only IgE production but also the Th1/Th2 imbalance during the development of allergic AHR. Absence of CD23 in gene-deficient mice significantly enhanced OA-specific IgE and IgG1 levels, airway eosinophilia, and AHR when compared with CD23+ / + wild-type littermates after sensitization and airway challenge. Sensitized and challenged CD23 transgenic mice also developed eosinophilic airway inflammation and methacholine hyperresponsiveness. However, the extent of AHR, BAL, and tissue eosinophilia in these animals showed a significant negative correlation with levels of CD23 expression on splenic T and B cells, demonstrating a limiting role of CD23 in the development of allergic AHR. Haczku A, Takeda K, Hamelmann E, Loader J, Joetham A, Redai I, Irvin CG, Lee JJ, Kikutani H, Conrad D, Gelfand EW. CD23 exhibits negative regulatory effects on allergic sensitization and airway hyperresponsiveness.
A piece of my mind. Portraits
Authors: J. D. Rowlett
Journal: JAMA (1990)

Early one Sunday morning, even before I had the chance to change into my scrubs, I received a stat page to the emergency room. I was only a few months into my internship, and though I was becoming familiar with routine calls, stat pages had a tendency to mean runs of V-tach—mine. I arrived at the emergency room simultaneously with the ambulance. A 2-year-old, found unresponsive by her parents, lay motionless on the gurney. She had been intubated by the paramedics, but her heart had failed to respond. Despite prolonged CPR, countless rounds of drugs, endless fluids, and a temporary pacemaker, the young heart remained silent. Reluctantly, I stopped the code. Explaining these events to Christy's parents was one of the most difficult experiences of my young career. Fortunately, the attending, who had supervised both the attempted resuscitation and my conversation, recognized my struggle. "You handled everything well," he reassured
Late Breaking News: Cancer Act Anniversary Encourages Reflection, New Visions
Authors: L. F. Anderson
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Late Breaking News: Cancer Act Anniversary Encourages Reflection, New Visions Get access Linda F. Anderson Linda F. Anderson Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 24, 18 December 1991, Pages 1795–1796, https://doi.org/10.1093/jnci/83.24.1795 Published: 18 December 1991
THE ACCEPTANCE OF THE PSYCHIATRIC WALK-IN CLINIC IN A HIGHLY DEPRIVED COMMUNITY
Authors: WILLIAM NORMAND, HERBERT FENSTERHEIM, GERALD TANNENBAUM, CLIFFORD J. SAGER
Journal: American Journal of Psychiatry (1963)

1. A major problem exists concerning the use of psychiatric facilities by people in economically deprived areas. It is suggested that the walk-in clinic may be a means of meeting this need; however, studies have indicated that people from such an area would be unlikely to make use of such a facility on a voluntary basis. The present study analyzed the intake data on 682 patients seen during a 6-month period in a walk-in clinic servicing such a deprived area. 2. The data collected show that: i. The patient group as a whole was of low socio-economic level; ii. The rate of self-referral in this group was 16%; iii. 46% of the patients presented their problems in psychological terms; iv. The self-referred group did not differ meaningfully from a clinic-referred group on a series of social variables 3. It is concluded that even without a community educational program, the walk-in clinic did make a contact with a significant number of residents of this deprived area.
Pravastatin reduces total mortality in patients with coronary heart disease and average cholesterol levels: relationship of baseline cholesterol and treatment effects in the LIPID trial
Authors: R.J. Simes, J. Baker, S. MacMahon, W. Hague, D. Colquhoun, M. West, M. Arulchelvam, J. Shaw, A. Tonkin
Journal: Journal of the American College of Cardiology (1998)
Interlaboratory reproducibility of standard accelerated aging methods for oxidation of UHMWPE
Authors: S.M Kurtz, O.K Muratoglu, F Buchanan, B Currier, R Gsell, K Greer, G Gualtieri, R Johnson, S Schaffner, K Sevo, S Spiegelberg, F.W Shen, S.S Yau
Journal: Biomaterials (2001)
Healing the injured vessel wall using microRNA-facilitated gene delivery
Authors: Mark W. Feinberg
Journal: Journal of Clinical Investigation (2014)

Drug-eluting stents have emerged as potent weapons in the treatment of patients with symptomatic coronary artery disease by reducing restenosis rates; however, a significant clinical consequence of these stents is delayed reendothelialization, which may increase the risk of late stent thrombosis. In this issue of the JCI, Santulli and colleagues generated an adenovirus that expresses the cyclin-dependent kinase inhibitor p27Kip1 (p27) and bears four tandem copies of target sequences for the endothelial cell–enriched microRNA (miRNA) miR-126-3p (Ad-p27-126TS) in an attempt to specifically reduce proliferation of vascular smooth muscle cells, but not endothelial cells. Indeed, delivery of Ad-p27-126TS to balloon-injured arteries in rats not only induced faster and more complete reendothelialization, but also effectively improved neointimal hyperplasia, hypercoagulability, and vasoreactivity. Collectively, these findings provide a cogent foundation for the potential therapeutic use of miRNA-facilitated gene delivery strategies to heal vessel wall injury.
Arc/Arg3.1 Is a Postsynaptic Mediator of Activity-Dependent Synapse Elimination in the Developing Cerebellum
Authors: Takayasu Mikuni, Naofumi Uesaka, Hiroyuki Okuno, Hirokazu Hirai, Karl Deisseroth, Haruhiko Bito, Masanobu Kano
Journal: Neuron (2013)
TWIN MONSTERS WITH ACUTE HYDRAMNIOS
Authors: A. E. Turnbull
Journal: BMJ (1912)

Samoa 82 r be seeni that the fragile attenuatedl ligaments had given way and( a second attemnpt to b-ring them up was unsuccessful.This was clearly a quiite unsuitable case for Gilliam's operationi.Of the 46 cases, 7 have passed suiccessfuilly through labour, 4 are pregnant, 3 have-had-abortions.IV. Retreversion wvith lUtcrine Fibroids;.This smnall 'class contains only fouir cases.Tlhree were single, one a married woman.In all mi,yoimectomy was performed, and the results have been good in all but one, where nienorrhagia persisted, necessitating hlysterectomy six miointlhs later.A sessile subnucous fibroid growing -froin the funidus was founld.In this case also the roundi(l ligantienits were very much hypertrophied.CONCLUSIONs'.From a study of this s'eries I coneluide:1.That Gilliam's operation is unifornmly sucees,-ful in.suitable cases-that is, wlhen the rouniid ligaimenlts are nlot too attenuiatedl.
Celiac Disease and T-Cell Lymphoma
Authors: Laurence J. Egan, Fiona M. Stevens, Ciaran F. McCarthy
Journal: New England Journal of Medicine (1996)

To the Editor: Case 15-1996 (May 16 issue)1 describes a typical case of celiac disease in an adult in whom a complicating T-cell lymphoma led to death. The chronically ill and malnourished conditio...
The combination of bendamustine, bortezomib, and rituximab for patients with relapsed/refractory indolent and mantle cell non-Hodgkin lymphoma
Authors: Jonathan W. Friedberg, Julie M. Vose, Jennifer L. Kelly, Faith Young, Steven H. Bernstein, Derick Peterson, Lynn Rich, Susan Blumel, Nicole K. Proia, Jane Liesveld, Richard I. Fisher, James O. Armitage, Steven Grant, John P. Leonard
Journal: Blood (2011)
Cartilage expression of a type II collagen mutation in an inherited form of osteoarthritis associated with a mild chondrodysplasia.
Authors: D R Eyre, M A Weis, R W Moskowitz
Journal: Journal of Clinical Investigation (1991)

In a family who expressed severe dominantly inherited osteoarthritis, the underlying mutation was traced by genomic sequencing to a single base change which predicts an amino acid substitution of cysteine for arginine at residue 519 of the triple-helical domain of the type II collagen molecule (Ala-Kokko, L., C. T. Baldwin, R. W. Moskowitz, and D. J. Prockop. 1990. Proc. Natl. Acad. Sci. USA. 87:6565-6568). In the present study we examined whether this predicted protein phenotype was evident in articular cartilage obtained from an affected family member who underwent hip surgery. The cartilage collagen was solubilized by CNBr digestion. Cysteine residues were labeled by reduction and alkylation with 14C-iodoacetate. Collagen CNBr-peptides were fractionated by ion exchange and reverse phase column chromatography. One peptide from the alpha 1(II) chain, alpha 1(II) CB8, was found to be radiolabeled. Tryptic peptides were prepared from it and identified by microsequence analysis. The results show that approximately one-quarter of the alpha 1(II) chains present in the polymeric extracellular collagen of the patient's cartilage contained the Arg519-to-Cys substitution. The protein exhibited other abnormal properties including disulfide-bonded alpha 1(II)-dimers and signs of posttranslational overmodification. The premature cartilage failure and osteoarthritis are presumably a result of the abnormal type II collagen being expressed in the cartilage matrix.
Postprandial Leptin Responses After an Oral Fat Tolerance Test
Authors: Stella Iraklianou, Andreas Melidonis, Symeon Tournis, Evangellia Konstandelou, Agathoklis Tsatsoulis, Moysis Elissaf, Dimitrios Sideris
Journal: Diabetes Care (2001)

The finding that circulating leptin concentrations exhibit a diurnal pattern (1,2), with peak nocturnal concentrations up to two times higher than nadir levels, raised the hypothesis that the evaluation of fasting leptin levels might have underestimated the effect of food secretagouges on postpradial leptin regulation and action. This variation in diurnal leptinemia is related to insulin excursions in response to meals (2), and shifting mealtime by 6.5 h without changing the light and sleep cycles will shift plasma-leptin rhythm by 5–7 h (3). In a recent study (4), it was reported that meals with high fat content result in the production of lower 24-h leptin concentrations compared with meals high in carbohydrates, a phenomenon attributed to lower insulin excursions after fatty meals. However, the impact of reduced insulin sensitivity on short-term leptin production in response to meals has not been investigated in subjects with similar degrees of obesity. We hypothesize that patients with type 2 diabetes (a well-established insulin-resitant state) show …
Hodgkin's Disease and
Authors: Herbert S. Heineman, Wallace N. Jensen, William M. Cooper, Abraham I. Braude
Journal: JAMA (1964)

Within a two-year period, three cases of Hodgkin's disease complicated by<i>Salmonella typhimurium</i>infection were seen. Patients with Hodgkin's disease characteristically suffer from a defect in cellular immunity. Since this type of immunity appears to be important in the defense against<i>Salmonella</i>, it is suggested that patients with Hodgkin's disease may be particularly susceptible to infection by these organisms. Other possible contributing factors are the presence of masses of neoplastic tissue and hemolysis. It is important to recognize this association and to consider salmonellosis among the possibilities in patients with Hodgkin's disease suffering a superimposed febrile illness.
Nonneoplastic nasal lesions in rats and mice.
Authors: T M Monticello, K T Morgan, L Uraih
Journal: Environmental Health Perspectives (1990)

Rodents are commonly used for inhalation toxicology studies, but until recently the nasal passages have often been overlooked or only superficially examined. The rodent nose is a complex organ in which toxicant-induced lesions may vary, depending on the test compound. A working knowledge of rodent nasal anatomy and histology is essential for the proper evaluation of these responses. Lack of a systematic approach for examining rodent nasal tissue has led to a paucity of information regarding nonneoplastic lesions in the rodent nose. Therefore, slides from the National Toxicology Program (NTP) and the Chemical Industry Institute of Toxicology (CIIT) were examined, and the literature was reviewed to assemble the spectrum of nonneoplastic rodent nasal pathology. Presented are lesions associated with the various types of epithelia lining the rodent nasal cavity plus lesions involving accessory nasal structures. Even though there are anatomic and physiologic differences between the rodent and human nose, both rats and mice provide valuable animal models for the study of nasal epithelial toxicity, following administration of chemical compounds.
Impact of the work environment on glycemic control and adaptation to diabetes.
Authors: P M Trief, C Aquilino, K Paradies, R S Weinstock
Journal: Diabetes Care (1999)

To evaluate quantitatively whether the work environments of adults with diabetes relate to the adequacy of metabolic control and/or to the individual's adaptation to diabetes and to explore qualitatively the interactions between an individual's life at work and ways of coping with diabetes.A total of 129 insulin-requiring adults who were employed outside of the home were assessed on a single occasion. They completed two work system measures (The Work Environment Scale and The Work Apgar Scale) and two quality-of-life measures (The Diabetes Quality of Life Scale and The Appraisal of Diabetes Scale). Subjects also participated in a semi-structured interview concerning the interaction of work and diabetes. Glycemic control was assessed by using HbAlc results. Demographic data (age, sex, diabetes type, duration of diabetes, number of diabetes-related medical complications) were gathered from the charts.Concerning glycemic control, neither of the work system measures was a significant predictor of HbAlc. Concerning psychosocial adaptation, supervisor support was found to be a significant predictor of positive appraisal and diabetes-related satisfaction. Involvement and coworker cohesion also predicted aspects of diabetes-related quality of life. Interview themes showed that for a minority (18%), diabetes affected choice of work and that for a majority (60%), diabetes affected relationships at work and raised financial/job concerns (49%). Most adjust their diet, blood glucose testing, and exercise regimen through work-related modifications.For insulin-treated adults with diabetes, work system variables do not directly relate to glycemic control, but they do relate to psychosocial adaptation. Future work should examine further the specific aspects of the workplace that might affect adaptation, with the goal being to develop worksite interventions that target not only the employee with diabetes but also their supervisors and coworkers.
Leukemic Cell Fragments Mimicking Platelets
Authors: Jaw H. Chen
Journal: JAMA (1978)

<h3>To the Editor.—</h3> Recently Armitage et al reported a case of acute leukemia with circulating leukemic cell fragments that artifactually elevated the platelet count (239:433-434, 1978). We would like to report a similar case. <h3>Report of a Case.—</h3> A 54-year-old man was hospitalized with a history of severe pain of the right thigh for two weeks. On admission he was found to have an enlarged liver and a gigantic spleen filling the entire left side of the abdomen. The initial WBC count was 100,400/cu mm with 78% blast cells. A smear of bone marrow showed hypercellularity mainly consisting of blast cells. A bone scan and roentgenologic study of the right femur were consistent with leukemic infiltration. The patient was treated with oral prednisone and intravenous vincristine weekly. In one month the pain of the right thigh subsided, and the WBC count returned to normal with a normal differential count. The
Self-reported influenza vaccination uptake in people with chronic diseases: data from Progressi delle Aziende Sanitarie per la Salute in Italia (PASSI)
Authors: Francesco Venturelli, Giuliano Carrozzi, Letizia Sampaolo, Lara Bolognesi, Sandro Baldissera, Nicoletta Bertozzi, Stefano Campostrini, Benedetta Contoli, Gianluigi Ferrante, Maria Masocco, Valentina Minardi, Angelo D'Argenzio, Pirous F Moghadam, Luana Penna, Alberto Perra, Elisa Quarchioni, Mauro Ramigni, Massimo O Trinito, Stefania Salmaso
Journal: The Lancet (2014)
Mathematical Modeling Predicts Synergistic Antitumor Effects of Combining a Macrophage-Based, Hypoxia-Targeted Gene Therapy with Chemotherapy
Authors: Markus R. Owen, I. Johanna Stamper, Munitta Muthana, Giles W. Richardson, Jon Dobson, Claire E. Lewis, Helen M. Byrne
Journal: Cancer Research (2011)

Tumor hypoxia is associated with low rates of cell proliferation and poor drug delivery, limiting the efficacy of many conventional therapies such as chemotherapy. Because many macrophages accumulate in hypoxic regions of tumors, one way to target tumor cells in these regions could be to use genetically engineered macrophages that express therapeutic genes when exposed to hypoxia. Systemic delivery of such therapeutic macrophages may also be enhanced by preloading them with nanomagnets and applying a magnetic field to the tumor site. Here, we use a new mathematical model to compare the effects of conventional cyclophosphamide therapy with those induced when macrophages are used to deliver hypoxia-inducible cytochrome P450 to locally activate cyclophosphamide. Our mathematical model describes the spatiotemporal dynamics of vascular tumor growth and treats cells as distinct entities. Model simulations predict that combining conventional and macrophage-based therapies would be synergistic, producing greater antitumor effects than the additive effects of each form of therapy. We find that timing is crucial in this combined approach with efficacy being greatest when the macrophage-based, hypoxia-targeted therapy is administered shortly before or concurrently with chemotherapy. Last, we show that therapy with genetically engineered macrophages is markedly enhanced by using the magnetic approach described above, and that this enhancement depends mainly on the strength of the applied field, rather than its direction. This insight may be important in the treatment of nonsuperficial tumors, where generating a specific orientation of a magnetic field may prove difficult. In conclusion, we demonstrate that mathematical modeling can be used to design and maximize the efficacy of combined therapeutic approaches in cancer.
Lesson of the week: Haemochromatosis as an endocrine cause of subfertility
Authors: M. J Tweed, J. M Roland
Journal: BMJ (1998)

Haemochromatosis should be considered and iron studies performed when investigating endocrine causes of infertility

Haemochromatosis is well established as a cause of infertility in both men and women, usually because iron deposition in the pituitary or the gonads leads to hypogonadism. As haemochromatosis is a fairly common disorder it should be considered when subfertility from an endocrine disorder is being investigated. We report on two related patients being investigated for subfertility in whom haemochromatosis was diagnosed only when one of them became diabetic.

### Case 1

A 32 year old man was referred to a tertiary referral centre for subfertility. He complained of failure of ejaculation and limited facial hair growth. Examination revealed female type and scanty axillary and pubic hair, soft testes (volume 8 …
Single or multiple daily doses of aminoglycosides: a meta- analysis
Authors: M. Barza, J. P. Ioannidis, J. C Cappelleri, J. Lau
Journal: BMJ (1996)

To assess relative efficacy and toxicity of aminoglycosides given by single daily dose compared with multiple daily doses.Meta-analysis of 21 randomised trials identified through MEDLARS (1966 to January 1995). Data were overviewed with fixed effects and random effects models and with meta-regression analysis.Total of 3091 patients with bacterial infection, most without pre-existing renal disease.Patients were randomized to receive aminoglycosides once daily or multiple times daily with similar total daily dose.Clinical failure of treatment, nephrotoxicity, ototoxicity, and mortality.Single daily dose regimen produced a non-significant decrease in risk of antibiotic failures (random effects risk ratio 0.83 (95% confidence interval 0.57 to 1.21)). Benefit of once daily dosing was greater when the percentage of pseudomonas isolates in a trial was larger. Once daily administration reduced risk of nephrotoxicity (fixed effects risk ratio 0.74 (0.54 to 1.00)). Similar trends were noted for patients with febrile neutropenia and for children. There was no significant difference in ototoxicity between the two dosing regimens, but the power of the pooled trials to detect a meaningful difference was low. There was no significant difference in mortality.Once daily administration of aminoglycosides in patients without pre-existing renal impairment is as effective as multiple daily dosing, has a lower risk of nephrotoxicity, and no greater risk of ototoxicity. Given the additional convenience and reduced cost, once daily dosing should be the preferred mode of administration.