tbuckley/cabot-search huggingface dataset:
New serological markers in inflammatory bowel disease are associated with complicated disease behaviour
Authors: M. Ferrante, L. Henckaerts, M. Joossens, M. Pierik, S. Joossens, N. Dotan, G. L Norman, R. T Altstock, K. Van Steen, P. Rutgeerts, G. Van Assche, S. Vermeire
Journal: Gut (2007)

<b>Background and aims:</b> Several antibodies have been associated with Crohn's disease and are associated with distinct clinical phenotypes. The aim of this study was to determine whether a panel of new antibodies against bacterial peptides and glycans could help in differentiating inflammatory bowel disease (IBD), and whether they were associated with particular clinical manifestations. <b>Methods:</b> Antibodies against a mannan epitope of <i>Saccharomyces cerevisiae</i> (gASCA), laminaribioside (ALCA), chitobioside (ACCA), mannobioside (AMCA), outer membrane porins (Omp) and the atypical perinuclear antineutrophilic cytoplasmic antibody (pANCA) were tested in serum samples of 1225 IBD patients, 200 healthy controls and 113 patients with non-IBD gastrointestinal inflammation. Antibody responses were correlated with the type of disease and clinical characteristics. <b>Results:</b> 76% of Crohn's disease patients had at least one of the tested antibodies. For differentiation between Crohn's disease and ulcerative colitis, the combination of gASCA and pANCA was most accurate. For differentiation between IBD, healthy controls and non-IBD gastrointestinal inflammation, the combination of gASCA, pANCA and ALCA had the best accuracy. Increasing amounts and levels of antibody responses against gASCA, ALCA, ACCA, AMCA and Omp were associated with more complicated disease behaviour (44.7% versus 53.6% versus 71.1% versus 82.0%, p &lt; 0.001), and a higher frequency of Crohn's disease-related abdominal surgery (38.5% versus 48.8% versus 60.7% versus 75.4%, p &lt; 0.001). <b>Conclusions:</b> Using this new panel of serological markers, the number and magnitude of immune responses to different microbial antigens were shown to be associated with the severity of the disease. With regard to the predictive role of serological markers, further prospective longitudinal studies are necessary.
IFN deficient C57BL/6 (H-2b) mice develop collagen induced arthritis with predominant usage of T cell receptor V 6 and V 8 in arthritic joints
Authors: C-Q Chu
Journal: Annals of the Rheumatic Diseases (2003)

Transgenic deficiency in interferon gamma (IFNgamma) or IFNgamma receptor makes resistant strains of mice bearing H-2(b) or H-2(d) susceptible to collagen induced arthritis (CIA).To determine whether the escape from regulation of disease susceptibility at the major histocompatibility complex level involves a new use of autoimmune T cells expressing T cell receptor (TCR) Vbeta that vary from the cell populations previously identified within arthritic joints.Arthritis was induced by a standard protocol with type II bovine collagen (CII) in complete Freund's adjuvant. Clinical features, histopathology, immunological responses, and TCR profile in arthritic joints in IFNgamma knockout C57BL/6 (B6.IFNgamma KO) mice (H-2(b)) were compared directly with those in DBA/1 mice (H-2(q)).60-80% of B6.IFNgamma KO mice developed a progressive arthritis with a similar clinical course to classical CIA in DBA/1 mice. The affected joints in B6.IFNgamma KO mice had an erosive form of arthritis with similar features to joint disease in DBA/1 mice. B6.IFNgamma KO mice produced significantly higher levels of IgG2b and IgG1 autoantibodies to murine CII and showed increased proliferative response to CII compared with B6 mice. Comparable levels of interleukin 1beta and tumour necrosis factor alpha expression were detected in arthritic joints from beta6.IFNgamma KO and DBA/1 mice. B6.IFNgammaKO mice used predominantly TCR Vbeta6 and Vbeta8 in arthritic joints. This TCR Vbeta profile is similar to that found in DBA/1 mice with CIA.C57BL/6 mice deficient in IFNgamma production can develop arthritis that resembles classical CIA. These data suggest that IFNgamma is a key factor mediating susceptibility to CIA.
A simple clinical screening test can identify elite female football players with increased knee valgus angles
Authors: A Nilstad, E Kristianslund, T Krosshaug, K Steffen, G Myklebust, R Bahr, T E Andersen
Journal: British Journal of Sports Medicine (2011)

Background A link has been suggested between increased dynamic knee valgus and the risk of anterior cruciate ligament (ACL) injuries in female athletes. However, these findings are based on complex time-consuming 3D motion analysis. There is a need for simple screening tools to identify athletes at increased risk of an ACL rupture. Objective To assess whether an experienced clinician can identify athletes with increased valgus angles and moments during a vertical drop jump using a simple screening test. Design Cross-sectional study. Participants Elite female football players. Methods Players in the Norwegian elite league (12 teams) were screened for potential risk factors for ACL injuries. Knee kinematics and kinetics in the landing phase of a 30 cm vertical drop jump were calculated using 3D motion analysis. Using a similar jump task, a physiotherapist assessed how well players stabilised their knees, and scored their knee control as ‘good’, ‘reduced’ or ‘poor’. Results Of the 136 players included, 38% were classified as ‘good’, 34% had ‘reduced’ control and 28% were scored as ‘poor’. Players with good control had significantly lower maximal valgus angles compared to players with poor control (0.5° vs 6.8°, p≤0.001). There were no differences in valgus moments (0.28 Nm/kg vs 0.28 Nm/kg, p=1.0). One-fifth of all players (17.6%) displayed valgus angles more than one SD above the mean in the 3D analyses (3.1° ±4.5°). The screening test captured 87.5% of these players. 22 (16.2%) players were classified in the ‘poor’ group without displaying high valgus angles. Conclusion The screening test identified 87.5% of players with increased valgus angles. No correlation was found between valgus angles and moments, and the test could not identify players with high valgus moments. Further investigations are needed to determine the cut-off value for defining high- versus low-risk groups, as well as the predictive value of the test.
Asthma, Nasal Polyposis, and Aspirin Sensitivity
Authors: J. C. DELANEY
Journal: Annals of Internal Medicine (1973)

Comments and Corrections1 November 1973Asthma, Nasal Polyposis, and Aspirin SensitivityJ. C. DELANEY, M.B., CH.B., M.R.C.P.J. C. DELANEY, M.B., CH.B., M.R.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-5-761_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I was interested to read the paper by Lockey, Rucknagel, and Vanselow, (Ann Intern Med 78:57-63, 1973) reporting two families with the syndrome of asthma, nasal polyposis, and aspirin sensitivity. Considering the relatively high prevalence of asthma occurring in families, familial aspirin-induced asthma appears to be rare, there being only one other case report in the literature (1). Samter and Beers (2) found no examples of familial aspirin disease in their groups of more than 1000 patients.In a group of 34 patients with this syndrome in Liverpool, the triad has been found in two members of...References1. MILLER F: Aspirin-induced bronchial asthma in sisters. Ann Allergy 29:263-265, 1971 MedlineGoogle Scholar2. SAMTERBEERS MR: Intolerance to aspirin. Clinical studies and consideration of its pathogenesis. Ann Intern Bed 68:975-983, 1968 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The United Liverpool Hospitals David Lewis Northern Hospital Liverpool England PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByComplementary Participation of Genetics and Epigenetics in Development of NSAID-exacerbated Respiratory DiseasePrevalence of Aspirin-Induced Asthma in Certain Group of Kosovo Population and its PresentationGenetic Mechanisms in Aspirin-induced AsthmaAnalgesics and Nonsteroidal Anti-Inflammatory DrugsNasal polyps and bronchial asthmaACETYLSALICYLIC ACID INTOLERANCE 1 November 1973Volume 79, Issue 5Page: 761-761KeywordsAspirinAsthmaBeer Issue Published: 1 November 1973 PDF DownloadLoading ...
Physicians Hear About Incontinence
Authors: Paul Cotton
Journal: JAMA (1990)

MOST ADULTS in diapers do not need to be. Urinary incontinence is usually treatable, often without surgery. The problem, say experts, is getting primary care physicians to provide this care. That may change. Diaper manufacturers are starting to advise users to consult physicians, and government regulators are likely to get involved. But, for the moment, incontinence is of little interest to many physicians, says L. Lewis Wall, MD, director of the Bladder Function Clinic at Duke University Medical Center, Durham, NC. Physicians ask patients, "What do you expect at your age?" says Cheryl Gartley, president of the Simon Foundation, a support group that is based in Wilmette, Ill, a suburb of Chicago. Or they tell them to "wait until it becomes more of a problem," says Peter Sand, MD, director of urogynecology at Rush Medical College of Rush University in Chicago. Half the patients who are referred to him, he
Complete common atrioventricular canal in infancy--surgical repair and postoperative hemodynamics.
Authors: W Culpepper, J Kolff, C Y Lin, D Vitullo, J Lamberti, R A Arcilla, R Replogle
Journal: Circulation (1978)

Fourteen infants with complete common atrioventricular canal (CCAVC) underwent open heart surgery under deep hypothermia and circulatory arrest. There were three operative deaths and two late deaths. Postoperative studies performed in seven of the nine survivors revealed nearly normal hemodynamics. There were no residual shunts, and excellent mitral valve function was observed in six patients. In one patient, residual mitral regurgitation was noted. The pulmonary artery pressures and pulmonary vascular resistances were normal except in one who had severe pulmonary vascular obstructive disease before surgery. The mean left ventricular end-diastolic volume changed from 175 +/- 24% (SEM) before surgery to 106 +/- 7% after surgery (P less than 0.01). The corresponding right ventricular end-diastolic volume changed from 166 +/- 16% to 102 +/- 19% (P less than 0.025). Left ventricular ejection fraction was mildly decreased before and after surgery (0.63 +/- 0.02). Surgical repair of CCAVC is possible during the first year of life, with likely normalization of cardiac size and function. Unsatisfactory results related to pulmonary vascular obstruction may be anticipated if repair is delayed much beyond the first year.
US doctors debate safety of abortifacient drug
Authors: Janice Hopkins Tanne
Journal: BMJ (2006)

Two pro-life doctors in the United States are calling for mifepristone to be withdrawn from the market after looking into reports filed to the Food and Drug Administration of adverse reactions.

Their request coincided with Senate hearings on the nomination to the Supreme Court of the controversial judge Samuel Alito, who favours ending women's right to abortion.

The doctors, Margaret Gary and Donna Harrison, members of a subcommittee of the American Association of Prolife Obstetricians and Gynecologists that is looking into the drug, analysed reports of 607 adverse events that they received after a request to the FDA under the terms …
Compression ultrasonography for diagnostic management of patients with clinically suspected deep vein thrombosis: prospective cohort study
Authors: A. Cogo, A. W A Lensing, M. M W Koopman, F. Piovella, S. Siragusa, P. S Wells, S. Villalta, H. R Buller, A. G G Turpie, P. Prandoni
Journal: BMJ (1998)

<h3>Abstract</h3> <b>Objective:</b> To evaluate the safety of withholding anticoagulant treatment from patients with clinically suspected deep vein thrombosis but normal findings on compression ultrasonography. <b>Design</b>: Compression ultrasonography was done with a simplified diagnostic procedure limited to the common femoral vein in the groin and the popliteal vein extending down to the trifurcation of the calf veins. Patients with normal ultrasonography findings at presentation were retested 1 week later. <b>Main outcome measure:</b> The incidence of venous thromboembolic complications during follow up for 6 months in patients in whom anticoagulant treatment was withheld on the basis of normal results on two ultrasonography tests 1 week apart. <b>Setting:</b> University research centres in four hospitals. <b>Results:</b> A total of 1702 patients were included in the study. Abnormal results on compression ultrasonography at presentation or at 1 week were found in 400 and 12 patients, respectively, for a prevalence of deep vein thrombosis of 24%. None of the patients were lost to follow up. Venous thromboembolic complications during the week of serial testing occurred in a single patient and in eight patients during 6 months9 follow up, resulting in a cumulative rate of venous thromboembolic complications of 0.7% (95% confidence interval 0.3% to 1.2%). The mean number of extra hospital visits and additional tests required per initially referred patient was 0.8. <b>Conclusion:</b> It is safe to withhold anticoagulant treatment from patients with clinically suspected deep vein thrombosis who have a normal result on compression ultrasonography at the time of presentation and at 1 week. <h3>Key messages</h3> Clinical diagnosis of suspected deep vein thrombosis is notoriously unreliable and objective diagnostic tests are indicated to confirm or refute the presence of this condition Ultrasonography with vein compressibility of the common femoral and popliteal vein is the non-invasive test of choice for the diagnostic management of patients with suspected deep vein thrombosis It is safe to withhold anticoagulant treatment from patients with suspected deep vein thrombosis who have normal results on compression ultrasonography on presentation and on a single repeat test 1 week later With the simplified compression ultrasound strategy the number of repeat tests can be safely reduced to a single test performed a week after presentation Most patients with deep vein thrombosis can be identified at presentation, making this strategy convenient to patients and less costly
Overexpression of the cancer-related DUSP1 gene in human obesity and its modulation by physical exercise
Authors: Abdelkrim Khadir, Ali Tiss, Jehad Abubaker, Mohamed Abu-farha, Said Dermime, Mohammed Dehbi
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Obesity is a major risk factor for metabolic diseases and cancer. Lifestyle interventions in obesity reduce the risk for cancer. Aberrant regulation of dual specificity protein phosphatase 1 (DUSP1) was linked to obesity and cancer representing an attractive therapeutic target and
Confounding and Simpson's paradox
Authors: S. A Julious, M. A Mullee
Journal: BMJ (1994)

Details ofreconstructive surgery and amputations carried out in districts with below (low volume) and above (high volume) the average rate of arterial reconstructions in the Oxford region.Values are numbers or proportions (percentages) Statistics High volume Low volume x2 df P value Referrals from outside the district 10/67 (15) 2/46 (4 3) 2-197 1 0-138 Balloon angioplasty before reconstructive surgery 23/67 (34) 3/41 (7-3) 8-729 1 0-0031 Types of infrainguinal graft: Femorotibial graft 17 (25) 4 (11) Femoropopliteal: 1 23-943 2 00001 Vein 31 (46) 4 (11) 293 2 000 Prosthesis 19 (28) 27 ( 77) Amputation rate per 100 000 population peryear (95% confidence interval) 6-1 (40 to 8 2) 10-3 (7-4to 13-2) 5-365 1 0-021 Ratio ofbelow knee to above knee amputations
ON THE MECHANISM OF CHLORIN RETENTION IN PNEUMONIA
Authors: Florentin Medigreceanu
Journal: The Journal of Experimental Medicine (1911)

THE FOLLOWING CONCLUSIONS MAY BE DRAWN FROM AN ANALYSIS OF THE PROTOCOLS: 1. The chlorin output is very much diminished during the process of experimental pneumonia in dogs (tables I and II). The quantity of chlorin retained in the cases with well developed exudates (table I) is much larger than the exudate could account for. 2. Turpentine pleurisy in dogs (tables III and IV) also is associated with a retention of chlorin, but this is not so marked as in pneumonia. There is no direct quantitative relation between the water output and the chlorin excretion. 3. The rabbits with pneumococcal septicemia (tables V and VI) did not retain chlorin in any phase of the disease, a fact which Hutchison has also noticed. It seems justifiable to conclude that the retention of chlorin in the organism in the course of pneumonia is conditioned by more than one factor. The formation of the exudate is one of these factors, but it alone is not capable of producing the same degree of chlorin retention as occurs in pneumonia. The additional factors are not yet determined; but it may be stated that the retention of chlorin is probably not due to the general effect of the pneumococcus on the organism or to its injury to the kidney. The principal cause of the retention seems, therefore, to be due to local changes associated with the pulmonary condition.
Studies on the Pathogenesis and Treatment of Idiopathic Hemochromatosis.
Authors: Roger Williams
Journal: Annals of Internal Medicine (1968)

s1 May 1968Studies on the Pathogenesis and Treatment of Idiopathic Hemochromatosis.Roger Williams, M.D.Roger Williams, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1191_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTwo currently controversial aspects of hemochromatosis are the role of increased iron absorption in its pathogenesis and the value of venesection therapy in its treatment.The results of 70 measurements in 40 patients showed that absorption was usually normal at the time of presentation although it increased rapidly during venesection therapy. After completion of treatment a wide range of values was found that could be related to the variable rate of reaccumulation of iron stores. The differential ferrioxamine test, which measures chelatable body iron, proved valuable in assessing such changes. Approximately a half of affected relatives had an increased iron... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: London, PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1191-1191KeywordsHemochromatosisPathogenesisPhlebotomy Issue Published: 1 May 1968 PDF DownloadLoading ...
Yersinia enterocolitica and the chronic fatigue syndrome
Authors: C.M.A. Swanink, V.M.M. Stolk-Engelaar, J.W.M. van der Meer, J.H.M.M. Vercoulen, G. Bleijenberg, J.F.M. Fennis, J.M.D. Galama, J.A.A. Hoogkamp-Korstanje
Journal: Journal of Infection (1998)
Upregulated expression of cardiac ankyrin repeat protein in human failing hearts due to arrhythmogenic right ventricular cardiomyopathy
Authors: Ying‐Jie Wei, Chuan‐Jue Cui, Yin‐Xia Huang, Xiao‐Lling Zhang, Hao Zhang, Sheng‐Shou Hu
Journal: European Journal of Heart Failure (2009)
Successful Treatment with Crizotinib in Mechanically Ventilated Patients with ALK Positive Non–Small-Cell Lung Cancer
Authors: Hee Kyung Ahn, Kyeongman Jeon, Hongseok Yoo, Boram Han, Su Jin Lee, Hyeyon Park, Min Ji Lee, Sang Yun Ha, Joung Ho Han, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park
Journal: Journal of Thoracic Oncology (2013)
Defective recognitive immunity in family aggregates of colon carcinoma.
Authors: N T Berlinger, C Lopez, M Lipkin, J E Vogel, R A Good
Journal: Journal of Clinical Investigation (1977)

Cancer-free individuals from family agregates of seemingly hereditary colon carcinoma were studied to determine the nature of their cell-mediated immune capacities in miexed leukocyte culture. Members of families who demonstrated no evidence of a precancerous condition such as polyposis coli did demonstrate substantial cellular immunopathology. Of these, 44% showed a decreased responsiveness of their peripheral mononuclear cells to allogeneic stimuli, and in a number of these individuals this deficiency clearly manifested itself as an inappropriate suppression of potentially normal lymphocyte blastogenic capacities by an adherent population of mononuclear leukocytes. This in vitro defect of recognitive immunity appears to be the same type of defect that has already been described for individuals with established maligancies. The pattern of phenotypic expression of this immunopathology within these families is not inconsistent with an hereditary disorder. Individuals from families with a known hereditary somatic precancerous condition usually did not demonstrate this immunopathology. It is appropriate to speculate that the defect of recognitive immunity in the former families could be contributory to the genesis of the colon carcinoma.
New Application of Dual Point 18F-FDG PET/CT in the Evaluation of Neoadjuvant Chemoradiation Response of Locally Advanced Rectal Cancer
Authors: Hai-jeon Yoon, Seok-ki Kim, Tae-Sung Kim, Hyung-Jun Im, Eun Seong Lee, Hyun Chul Kim, Ji Won Park, Hee Jin Chang, Hyo Seong Choi, Dae Yong Kim, Jae Hwan Oh
Journal: Clinical Nuclear Medicine (2012)

Purpose FDG PET/CT has been suggested as the most reliable modality to predict pathological tumor responses after neoadjuvant chemoradiotherapy (CRT) in locally advanced rectal cancer (LARC). However, several confounding factors including radiation-induced inflammation could not be easily avoided with the commonly used single-point FDG PET/CT. Our aim was to evaluate the accuracy of a dual-point PET/CT protocol in LARC response prediction to CRT. Patients and Methods Sixty-one LARC patients were enrolled and treated with neoadjuvant CRT. PET/CT was performed before and after CRT. Dual-point acquisition was applied to post-CRT PET/CT. Post-CRT SUVmax (postSUV), pre/post-CRT SUVmax change (RI), and dual-point index (DI) of post-CRT PET/CT were compared with the Dworak tumor regression grade (TRG) as a gold standard. Univariate and multivariate analyses, as well as receiver operating characteristic curve analysis, were used to evaluate the predictive ability of demographic, clinical, and metabolic PET parameters. Results Fifteen patients of TRG3-4 were defined as pathological responders, and 46 patients of TRG1-2 were nonresponders. The resulting response index (RI) ranged from −13 to 94.8% (59.1 ± 22.0%), and delay index (DI) ranged from −45.2 to 25.0% (−9.1 ± 12.1%). Univariate analysis resulted in PET parameters (postSUV, RI, and DI) as significant predictors (P = 0.004, P < 0.001, P < 0.0001). According to multivariate analysis, RI and DI remained as significant predictors (P = 0.04 and P = 0.0004). Receiver operating characteristic analysis showed that DI had significantly higher area under the curve compared with RI (0.906 vs 0.696, P = 0.018). Delay index had 86.7% sensitivity, 87.0% specificity, 68.4% positive predictive value, 95.2% negative predictive value, and 86.9% accuracy. Conclusions Dual-point post-CRT PET/CT can predict pathological tumor response better than conventional single time point pre- and post-CRT PET/CT.