Tear-Duct Fibrosis (Dacryostenosis) Due to 5-Fluorouracil
Authors: D. J. HAIDAK
Journal: Annals of Internal Medicine (1978)

Brief Reports1 May 1978Tear-Duct Fibrosis (Dacryostenosis) Due to 5-FluorouracilD. J. HAIDAK, M.D., BYRON S. HURWITZ, M.D., K. Y. YEUNG, M.D., F.A.C.P., F.R.C.P.(C)D. J. HAIDAK, M.D., BYRON S. HURWITZ, M.D., K. Y. YEUNG, M.D., F.A.C.P., F.R.C.P.(C)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-5-657_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Excerpt5-fluorouracil is possibly the most commonly used member of the chemotherapeutic armamentarium. Consequently the adverse reactions to its use are many. However, with the exception of conjunctival redness (1), adverse reactions involving the eye and related structures due to systemically administered chemotherapy in general and 5-fluorouracil specifically have not been notably reported; we, therefore, report a reaction to 5-fluorouracil that has been touched upon only briefly in the literature.Within the past 2 years we assumed the care of six patients who had been on long-term weekly intravenous 5-fluorouracil therapy (five for colon cancer, one for recurrent breast cancer). All...References1. BONADONNABRUSAMOLINOVALAGUSSAROSSIBRUGNATELLIBRAMBILLADELENATANCINIBAJETTAMUSUMECIVERONESI GEPALCMGERU: Combination chemotherapy as an adjuvant treatment in operable breast cancer. N Engl J Med 294:405-410, 1976 CrossrefMedlineGoogle Scholar2. HAMERSLEYLUCEFLORENTZBURKHOLDERPEPPER JJTMJ: Excessive lacrimation from fluorouracil treatment. JAMA 225:748-749, 1973 CrossrefGoogle Scholar3. STRAUSMAUSOLFELLERBYMCCRACKEN DFRJ: Cicatricial ectropion secondary to 5-fluorouracil therapy. Med Pediatr Oncol 3:15-19, 1977 CrossrefMedlineGoogle Scholar4. SHAFFERRIDGWAY RW: Furmethide iodide in the production of dacryostenosis. Am J Ophthalmol 34:718, 1951 CrossrefMedlineGoogle Scholar5. MCGILLWILLIAMSMCKINNON JHJ: Reassessment of idoxuridine therapy of herpetic keratitis. Trans Ophthalmol Soc UK 94:542, 1974 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Georgetown University Hospital Washington, D.C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByProximal lacrimal obstructions: a reviewCanalicular Stenosis Secondary to Chemotherapeutic AgentsOculoplastic Complications of Cancer TherapyOcular surface complications of local anticancer drugs for treatment of ocular tumorsClinical features and treatment outcomes of patients with tearing after chemotherapyEvaluation and Management of Chemotherapy-Induced Epiphora, Punctal and Canalicular Stenosis, and Nasolacrimal Duct ObstructionComparison of botulinum toxin-A injection in lacrimal gland and conjunctivodacryocystorhinostomy for treatment of epiphora due to proximal lacrimal system obstructionPredictive factors for ocular complications caused by anticancer drug S-1FluorouracilBilateral Lacrimal Drainage Obstruction and Its Association With Secondary CausesOculoplastic Complications of Cancer TherapyAnatomy, Imaging, and Pathology of the Lacrimal ApparatusNasolacrimal Duct Obstruction and Lacrimal Surgery in Cancer PatientsLacrimal and Canalicular ToxicityDRUGS USED IN CANCER CHEMOTHERAPYIdentifying an Appropriate Animal Model for the Nasolacrimal Drainage SystemEvaluation of the Tearing PatientDocetaxel-Associated EpiphoraFluorouracilBotulinum Toxin for Palliative Treatment of Epiphora in a Patient with Canalicular ObstructionNasolacrimal Duct Obstruction Associated With Radioactive Iodine Therapy for Thyroid CarcinomaDocetaxel-Induced Histologic Changes in the Lacrimal Sac and the Nasal MucosaOcular Surface, Ocular Adnexal, and Lacrimal Complications Associated With the Use of Systemic 5-FluorouracilEpiphora Induced by Intermittent Docetaxel (Taxotere) in Patients with Non-small Cell Lung CancerSquamous metaplasia of the canaliculi associated with 5-fluorouracil: a clinicopathologic case report11The authors have no proprietary interest in any of the materials used in this study.A Phase I Study of Weekly Docetaxel, 24-Hour Infusion of High-Dose Fluorouracil/Leucovorin and Cisplatin in Patients with Advanced Gastric CancerLacrimal Duct Stenosis and Other Ocular Toxicity Associated with Adjuvant Cyclophosphamide, Methotrexate and 5-Fluorouracil Combination Chemotherapy for Early Stage Breast CancerCanalicular stenosis secondary to docetaxel (taxotere)Cytostatic drugsThe Treatment of Punctal and Canalicular Stenosis in Patients on Systemic 5-FUPunctal and canalicular stenosis associated with systemic fluorouracil therapy5-Fluorouracil and ocular toxicity.The Wedge Punctoplasty for Treatment of Punctal StenosisBilateral total corneal epithelial erosion as a side effect of cytotoxic therapyCyclophosphamide, Methotrexate, and 5-Fluorouracil (CMF)-Induced Ocular ToxicityOcular complications of systemic cancer chemotherapySurviving Adult Cancers. Part 1: Physiologic EffectsLois J. Loescher, RN, MS, Deborah Welch-McCaffrey, RN, MSN, Susan A. Leigh, RN, BS, Barbara Hoffman, JD, Frank L. Meyskens Jr, MDGlaucoma Filtering Surgery with 5-FluorouracilCytotoxicity of antineoplastic agents on rabbit corneal epithelium in vitro5-Fluorouracil and Glaucoma Filtering SurgerySurgical treatment of punctal-canalicular fibrosis from 5-fluorouracil therapy5-Fluorouracil and Glaucoma Filtering SurgeryOcular toxicity from high-dose cytosine arabinosideOcular Toxicity of Antineoplastic AgentsOcular Side Effects of Cancer ChemotherapyOcular irritation from high-dose methotrexate therapy: Pharmacokinetics of drug in the tear filmEye toxicity of cancer chemotherapy: A review of the literatureOcular Side Effects with 5-FluorouracilCytostatic and immunosuppressive drugsLacrimation and 5-FluorouracilN. CHRISTOPHIDIS, M.B., I. LUCAS, PH.C., F. J. E. VAJDA, M.D., F.R.A.C.P., W. J. LOUIS, M.D., F.R.A.C.P. 1 May 1978Volume 88, Issue 5Page: 657-657KeywordsAdverse reactionsBreast cancerChemotherapyColorectal cancerFibrosisPatients Issue Published: 1 May 1978 PDF DownloadLoading ...