tbuckley/cabot-search huggingface dataset:
CARE OF THE EYES OF THE PATIENT DURING ETHERIZATION
Authors: Albert H. Miller
Journal: JAMA (1918)

It is fortunate that conjunctivitis is an infrequent post-anesthetic complication as, when it occurs, the pain resulting from the conjunctivitis is likely to be so severe as to outweigh any other discomfort that may follow the operation. Conjunctivitis is supposed to follow exposure of the eyes to ether vapor, or to result from the spilling of the liquid anesthetic on them. In the anesthetic literature, mention of this question is limited to directions for covering the eyes with a towel, gauze handkerchief, or a strip of rubber tissue for the purpose of protection from the anesthetic vapor. In cases in which these precautions have been carefully taken, conjunctivitis occasionally develops. In a series of 3,000 cases of ether anesthesia by the open method in which the eyes were not covered, although they were exposed to the ether vapor and although liquid ether was without doubt accidentally spilled over the eyes
Myocardial and coronary vascular effects of salbutamol
Authors: G. ROSS
Journal: Cardiovascular Research (1974)

Journal Article Myocardial and coronary vascular effects of salbutamol Get access GORDON ROSS GORDON ROSS 2 From the Department of Cardiology, St Bartholomew's Hospital, London 2Present address: Department of Physiology, UCLA School of Medicine, Los Angeles, California 90024, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 8, Issue 1, January 1974, Pages 1–7, https://doi.org/10.1093/cvr/8.1.1 Published: 01 January 1974
Pharmacokinetics of vinylidene chloride in the rat.
Authors: M J McKenna, P G Watanabe, P J Gehring
Journal: Environmental Health Perspectives (1977)

The metabolism of inhaled vinylidene chloride in rats represents a balance of biotransformation pathways leading to the formation of a reactive alkylating species which is normally detoxified by conjugation with glutathione. Detoxification of the reactive intermediate formed from inhaled VDC is dependent upon the availability of hepatic glutathione (GSH); as VDC exposure concentrations are increased, the fraction of the dose detoxified by conjugation with GSH decreases markedly, commensurate with depletion of hepatic GSH. This reactive intermediate in the absence of GSH alkylates hepatic macromolecules and causes cell death. Similarly, hepatic GSH plays a vital role in the detoxification of the reactive metabolite formed from inhaled vinyl chloride (VC). However, the dose--response relationships for the utilization of GSH and the accumulation of alkylating metabolites following inhalation exposure to either VDC or VC point to distinct differences which may explain the differing biological activities of the two materials. Finally, preliminary pharmacokinetic data for inhaled VDC in mice indicate an enhanced susceptibility to VDC by virtue of an increased ability for production of alkylating VDC metabolites over that observed in the rat. The importance of these findings in light of recent evidence for a carcinogenic effect of VDC in mice is discussed.
PREVALENCE OF DEFICIENT RETRO-AORTIC RIM AND ITS EFFECT ON OUTCOME IN DEVICE CLOSURE OF ATRIAL SEPTAL DEFECTS
Authors: Michael L. O'Byrne, Andrew Glatz, Sherzana Sunderji, Aswathi Mathew, David Goldberg, Yoav Dori, Jonathan Rome, Matthew Gillespie
Journal: Journal of the American College of Cardiology (2014)
Sequential Technetium-99m Sulfur Colloid/lndium-111 White Blood Cell Imaging in Macroglobulinemia of Waldenstrom
Authors: DARLENE FINK-BENNETT, HELENA R. BALON, RONALD IRWIN
Journal: Clinical Nuclear Medicine (1990)

Technetium-99m sulfur colloid (SC) and indium-111 labeled leukocyte (ln-111 WBC) scintigraphy was performed on a 77-year-old female patient to rule out a left periprosthetic infection. Anterior Tc-99m SC and ln-111 WBC images of the pelvis and femurs revealed no abnormal deposition of radiotracer about the Austin—Moore prosthesis. Absent radiotracer uptake, however, was demonstrated within the left hemipelvis. A left iliac bone marrow aspirate and biopsy revealed a lymphoplasmacytic infiltrate consistent with Waldenstrom's macroglobulinemia.
Current Med Talk: A Dictionary of Medical Terms, Slang and Jargon
Authors: John H. Dirckx
Journal: JAMA (1996)

For the medical practitioner, investigator, or writer, standard medical dictionaries have some serious shortcomings. They devote as much space to the established and the familiar as to the brand-new and the arcane. They say too little about recent discoveries, developments, and trends, and they say it too late. Joseph C. Segen's<i>Current Med Talk</i>, which began life as an electronic database to help the author study for pathology boards, is intended to complement, not supplant, conventional medical dictionaries. It is a kind of encyclopedia of contemporary medical concepts and their terminology, emphasizing definitions or explanations of terms that have not yet appeared in other reference works and giving proportionately more space to hot or fashionable topics. The distribution of material is slightly weighted in favor of histopathology and pathophysiology, but molecular biology, medical imaging, general clinical medicine, and political, legal, and fiscal aspects of medicine are well represented. Nearly half
Abstract B72: CX3CR1, a fractalkine receptor, can regulate peritoneal dissemination of epithelial ovarian cancer cells
Authors: Jia Xie, Hilal Gurler, Joanna Burdette, Maria Barbolina
Journal: Cancer Research (2013)

Abstract Epithelial ovarian carcinoma (EOC) is a leading cause of death from gynecologic malignancies mainly due to metastasis. EOC metastases spread by shedding the malignant cells off from the ovarian surface and seeding to organs and tissues in the peritoneal cavity. The current standard of care, a combination of chemotherapy and surgery, fails to keep patients in remission. Thus, mechanistic understanding of the biology of EOC metastasis and identification of novel targetable molecules are crucial for the development of improved therapeutic approaches. Fractalkine receptor (CX3CR1) belongs to a chemokine family of G-protein coupled receptors. CX3CR1 is expressed by EOC cells and promotes cell migration and proliferation. CX3CR1-positive EOC cells have been shown to adhere to the CX3CL1-positive peritoneal mesothelial cells in vitro. Thus, we hypothesized that CX3CL1/CX3CR1 axis could be important for peritoneal dissemination of metastatic EOC. In order to test this hypothesis, we performed short-term ex vivo and in vivo adhesion assays, as well as long-term metastasis formation assay. We found that EOC cells prefer omentum to other peritoneal tissues during the short-term in vivo and ex vivo adhesion. Importantly, reduction of CX3CR1 expression in EOC cells resulted in significantly reduced peritoneal adhesion. Furthermore, reduced adhesion correlated with the ability of EOC cells to form overt metastasis. Microenvironmental milieu has been histologically evaluated for stromal cells in the omentum expressing CX3CL1. Taken together, our data indicate that fractalkine signaling is one of the central regulators of EOC metastasis. Citation Format: Jia Xie, Hilal Gurler, Joanna Burdette, Maria Barbolina. CX3CR1, a fractalkine receptor, can regulate peritoneal dissemination of epithelial ovarian cancer cells. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Invasion and Metastasis; Jan 20-23, 2013; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2013;73(3 Suppl):Abstract nr B72.
Evidence of a common regulation of IgE and IgG‐subclass antibodies in humans during immunotherapy
Authors: I. Søndergaard, L. K. Poulsen, O. Østerballe, B. Weeke
Journal: Allergy (1992)

Based on a 3‐year prospective study of 20 pollen‐allergic patients, where a detailed analysis of the IgE, IgG, and IgG 4 immune response was performed, we propose that a common regulatory mechanism exists between the IgE and IgG 1 synthesis and between IgE and IgG 4 synthesis during immunotherapy. It was found that the IgE immune response to a number of antigens was quantitatively diminished during the period of immunotherapy when IgG 1 was present early (week 12), and for other antigens there was a rise in IgE without an early IgG 1 antibody response. Additionally, it was found that for some antigens a rise in IgE antibodies was contrasted by a fall in the IgG 4 antibody response and for other antigens the opposite was true, indicating a regulatory mechanism between the IgE and the IgG 4 synthesis. A statistical analysis showed that these findings were statistically significant at the 0.01 % level for the IgE/IgG 1 relationship and at the 0.05% level for the IgE/IgG 4 relationship. These findings could have implications for future immunotherapy regimens.
Surgical Management of Juvenile Chronic Polyarthritis
Authors: Riad Barmada
Journal: JAMA (1979)

This book includes a good discussion of the management of joint problems encountered mainly in juvenile rheumatoid arthritis, with a focus on surgical management. A brief outline of the roentgenographic changes and histology of juvenile rheumatoid arthritis is included. Juvenile rheumatoid arthritis is not a common disease, and surgery is performed on a small number of patients. For this reason, a large series on surgical treatment is not found in the literature. The authors gave their impressions and advice based on their experience with the various types of surgical procedures; it is understandable that this experience is not large in some areas. The book is helpful to physicians who are involved in treating juvenile rheumatoid arthritis, such as orthopedic surgeons, pediatricians, and rheumatologists.
Progress in Medical Writing (or the Lack of It)
Authors: Hugh H. Hussey
Journal: JAMA (1975)

If you are not in the habit of reading "JAMA 75 Years Ago," or if you failed to find the item in the July 21, 1975, issue because it was tucked away on page 235 at the end of "Reference Directories," seek it out, especially if you are interested in writing something for publication in one of AMA's scientific journals. The item consisted of an editorial published in<i>JAMA</i>on pages 164 and 165 precisely 75 years earlier. At that time, the medical centers in parts of Europe and the British Isles, with few exceptions, far outshone those in the United States. It was customary for US physicians who aspired to clinical excellence to travel abroad for postgraduate education. If they went to the right places and stayed long enough (and many of them did both), they returned to this country greatly enriched by their experience. Since treatment of diseases
CHRONIC SODIUM CHLORIDE TOXICITY IN THE ALBINO RAT
Authors: George R. Meneely, Robert G. Tucker, William J. Darby, Stewart H. Auerbach
Journal: The Journal of Experimental Medicine (1953)

Sustained arterial hypertension developed in male, albino rats chronically fed diets rich in sodium chloride with demineralized drinking water available ad libitum. After 12 months of the experimental regimen a positive, linear correlation (r = 0.91) was found between the systolic blood pressure and the concentration of sodium chloride in the diet. A syndrome of edema and renal failure was observed in 18 per cent of the group fed at the level of 7.0 to 9.8 per cent of sodium chloride. Significant histologic changes occurred in the kidneys and certain other organs in rats consuming rations containing these levels of NaCl. The relative volume of the radiosodium space was increased in the rat by high dietary sodium chloride.
The Roles for Nurses
Authors: Roger O. Egeberg
Journal: JAMA (1972)

In examining the potential for extending the contribution of nursing in the delivery of health care, we were reminded that concepts such as health care should reflect patient needs rather than professional prerogatives, and that those who provide health care should work as a team whenever the needs of the patient and his family warrant. Concepts such as these, while honored in principle, are likely to be dishonored or disregarded in practice. The health professions themselves are the parties to this failure, but the consumers of health services have the most at stake in efforts to correct it. The extent to which health professionals succeed in translating sound principles into responsible practice will profoundly affect the quality, effectiveness, and cost of health care. What is involved ultimately is a fundamental improvement in the health care delivery system, a goal the American people expect, the health professions espouse, and the President
Editorial: What Caused All These Troubles, Anyway? Epstein‐Barr Virus in Sjögren's Syndrome Reevaluated
Authors: John B. Harley, Erin E. Zoller
Journal: Arthritis & Rheumatology (2014)

The inflammatory autoimmune and autoinflammatory rheumatic diseases share the persistent, pernicious, and currently depressing feature that they are largely idiopathic. Their true environmental origins remain unknown - or at least there is no general convincing and agreed upon consensus that explains their causation – and this is despite the extraordinary efforts made to date and the awesome capabilities of modern science. Of course, there are exceptions to such a gross generalization. Knowing that the host response to Streptococci is responsible for rheumatic fever, for example, seems to have contributed to our therapeutic success with this disease and its demise as a public health scourge, despite the many important details that remain unexplained about the relationship of this bacterium to the host response and the vagaries of disease expression.
Increase in rat aortic endothelial free calcium mediated by metabolically sensitive calcium release from endoplasmic reticulum
Authors: R. C Ziegelstein, L. Cheng, T. Aversano, P. Ouyang, E. G Lakatta, H. S Silverman
Journal: Cardiovascular Research (1994)

Objective: The aim was to examine the relationship between cellular metabolism and intracellular [Ca2+] in vascular endothelial cells, focusing on the timing, mechanism, and reversibility of intracellular [Ca2+] changes resulting from ATP depletion. Methods: Cultured rat aortic endothelial monolayers were loaded with indo-1 and exposed for 30 min to: (1) glucose-free buffer, (2) 10 mM deoxyglucose or iodoacetic acid (0.1 or 2.5 mM) to inhibit glycolysis, or (3) 2 mM NaCN to inhibit oxidative phosphorylation with or without glucose. In other experiments, the pH sensitive fluorescent indicator SNARF-1 was used to assess the relationship between observed changes in [Ca2+] and pH. Results: While glucose deprivation resulted in a minor increase in [Ca2+], glycolytic inhibition resulted in a larger, slowly developing, sustained increase in [Ca2+]. Endothelial [Ca2+] was not affected by inhibition of oxidative phosphorylation alone, whereas a rapid, sustained, and largely reversible increase (∼102 nM) occurred when NaCN exposure was combined with glucose deprivation. The increase in [Ca2+] during glucose-free NaCN exposure was not altered when calcium influx was prevented by removal of extracellular calcium, but was abolished following depletion of an intracellular calcium store by the endoplasmic reticular Ca2+−ATPase inhibitor thapsigargin. In SNARF-1 loaded monolayers, inhibition of glycolysis with iodoacetic acid decreased intracellular pH by 0.33(SEM 0.10) units whereas inhibition of oxidative phosphorylation in the absence of glucose increased intracellular pH by 0.17(0.05) units. While these divergent pH changes were noted, [Ca2+] increased in both groups. Conclusions: A metabolically sensitive endoplasmic reticular calcium store is rapidly and reversibly released in vascular endothelial cells. Endothelial [Ca2+] is shown to be dependent on glycolytic energy production. In the endothelial cell, brief periods of inhibition of oxidative phosphorylation in the absence of glucose rapidly affect intracellular calcium pools rather than leading to calcium influx due to non-specific cellular damage. Effects on intracellular pH alone cannot account for the changes in [Ca2+]. Cardiovascular Research 1994;28:1433-1439
INDUCTION OF BONE MARROW COLONY-STIMULATING ACTIVITY BY A FILTERABLE AGENT IN LEUKEMIC AND NORMAL MOUSE SERUM
Authors: Roger Foster, Donald Metcalf, Rosemary Kirchmyer
Journal: The Journal of Experimental Medicine (1968)

1. Leukemic Swiss mice of ICR/Ha strain which had been injected at birth with a lymphoid-leukemia-inducing virus preparation yielded sera which produced elevations of serum colony-stimulating activity within 16 hr and significant plasma-LDH-enzyme elevation at 4 days when injected intraperitoneally into normal ICR/Ha Swiss mice. Colony-stimulating activity was assayed in vitro by the stimulation of hemopoietic colony formation by DBA/1 bone marrow cells. 2. The inducing agent in leukemic serum was passageable, filterable, sedimentable, and heat-, ether-, and UV-labile. 3. A similar agent was recovered from normal Swiss serum after blind serial passages through normal mice. 4. LDH elevating virus induced a similar elevation of serum colony-stimulating activity when injected at high titers, and cross-resistance was demonstrated between LDH virus and the passaged leukemic serum agent.
Treatment with gonadotrophin releasing hormone analogue in advanced prostatic cancer.
Authors: J H Waxman, J A Wass, W F Hendry, H N Whitfield, G M Besser, J S Malpas, R T Oliver
Journal: BMJ (1983)

Repeated administration of long acting analogues of gonadotrophin releasing hormone diminishes gonadal function and in men decreases testosterone concentrations; for this reason the effect of the analogue buserelin was studied in prostatic carcinoma. Twelve consecutive patients with newly diagnosed locally advanced or metastatic carcinoma of the prostate were treated. Each patient received intranasal buserelin in divided dosages of either 600 or 1000 micrograms daily. Suppression of the gonadotrophins and testosterone occurred in all patients. Objective and subjective signs of regression of disease were seen in nine patients. Buserelin offers an effective treatment of metastatic prostatic cancer without the side effects and cardiovascular risks associated with oestrogen treatment.
In nondiabetic, human immunodeficiency virus–infected patients with lipodystrophy, hepatic insulin extraction and posthepatic insulin clearance rate are decreased in proportion to insulin resistance
Authors: Steen B. Haugaard, Ove Andersen, Birgitte R. Hansen, Ulrik B. Andersen, Aage Vølund, Johan Iversen, Jens Ole Nielsen, Sten Madsbad
Journal: Metabolism (2005)
Infectious hepatitis. Evidence for two distinctive clinical, epidemiological, and immunological types of infection
Authors: S. Krugman
Journal: JAMA (1967)

The identification of two types of infectious hepatitis with distinctive clinical, epidemiological, and immunological features provided an explanation for the occurrence of second attacks of the disease. One type resembled classical infectious hepatitis (IH); it was characterized by an incubation period of 30 to 38 days, a relatively short period of abnormal serum transaminase activity (3 to 19 days), a consistently abnormal thymol turbidity, and a high degree of contagion. The other type resembled serum hepatitis (SH); it was characterized by a longer incubation period (41 to 108 days), a longer period of abnormal transaminase activity (35 to 200 days) and a relatively normal thymol turbidity. Contrary to commonly accepted concepts, the SH type was moderately contagious. Patients with IH type were later proved to be immune to the same type. Patients with the SH type were not immune to the IH type infection.
Medical Group Practice in the United States
Authors: G. Halsey Hunt, Marcus Goldstein
Journal: New England Journal of Medicine (1947)

THIS is the second of a series of reports on the purposes and findings of a study of medical group practice conducted by the United States Public Health Service.During the first eight months of 1946, technics for the study of group-practice units were worked out and tested in studies of five groups in New England and the Middle Atlantic states. The general method of study, outlined in the first paper of this series,1 involves approaches by two technics: an intensive interview survey of the physicians and key administrative personnel of the group, and a statistical analysis of a random . . .
A fast assay to gauge for TAA-reactive T cells in PBMCS from patients with pancreatic cancer
Authors: Elena B Rangelova, Qingda Meng, Liu zhenjiang, Thomas Poiret, Bartek Jiri, Caroline Verbeke, Ernest Dodoo, Ralf Segersvärd, Markus Maeurer
Journal: Journal for ImmunoTherapy of Cancer (2014)

Meeting abstracts Active cellular therapy (ACT) using ex-vivo expanded T cells from patients with cancer, obtained by apheresis, can represent a viable source for anti-cancer directed cellular therapy. We established a T cell expansion protocol using 2 rounds of re-stimulation with TAA peptides
The Diagnosis of Intracranial Lesions in AIDS
Authors: Ira C. Denton
Journal: JAMA (1985)

<h3>To the Editor.—</h3> We wish to comment on the observations of Elkin et al<sup>1</sup>and to address specifically the topic of biopsy of intracranial lesions in patients with the acquired immunodeficiency syndrome (AIDS). With the availability of computed tomographic (CT) scan—directed stereotactic surgical systems, we no longer consider clinical and roentgenographic criteria sufficient for the diagnosis and treatment of most patients with AIDS who have intracranial lesions. As the authors note, the varieties of pathogens and neoplasms known to affect patients with AIDS range from the ordinary to the bizarre, and different processes may coexist. Unfortunately, the brain's rather stereotypical mechanisms of response to this host of potential challenges result in CT images of limited diagnostic specificity; dissimilar processes thus may mimic one another. In an area of such complexity, diagnostic accuracy requires an analysis of biopsy material. Therapy based on clinical and roentgenographic criteria alone must be reserved
Human peritoneal mesothelial cell prostaglandin synthesis: Induction of cyclooxygenase mRNA by peritoneal macrophage-derived cytokines
Authors: Nicholas Topley, Meryl M. Petersen, Ruth Mackenzie, Andreas Neubauer, Eleni Stylianou, Volkard Kaever, Malcolm Davies, Gerald A. Coles, Achim Jörres, John D. Williams
Journal: Kidney International (1994)
A conversation with Bonnie Bassler
Authors: Ushma S. Neill
Journal: Journal of Clinical Investigation (2014)

Bonnie Bassler of Princeton University and the Howard Hughes Medical Institute has revolutionized the way that we think about microbiology. She elucidated the chemical language that bacteria use to communicate through a process called quorum sensing that allows bacteria to count their numbers, determine when they’ve reached a critical mass, and then change their behavior in unison to result in virulence or even bioluminescence. Called everything from a [MacArthur] genius to the bacteria whisperer, Bassler (Figure ​(Figure1)1) also excels at the art of scientific communication, has dabbled in theater, and many mornings a week leads an aerobics class in Princeton. The full interview with many more stories can be seen on the JCI website, http://www.jci.org/kiosk/cgm.