tbuckley/cabot-search huggingface dataset:
Pregnancy and Labour in a Case of Congenital Coarctation of the Aorta
Authors: C. W. Walker
Journal: BMJ (1943)

MEDICAL JOURN~AL sedimentation rate (Westergren-Biernacki) was never above 8 mm.an hour.The Wassermann reaction of the serum was negative.Guinea-pigs inoculated with the serous fluid from the soles and palms developed the typical signs and symptoms of f.a.m.d. after
Clinical evaluation of a<i>T. rubrum</i>-specific polymerase chain reaction and pandermatophyte polymerase chain reaction in the diagnosis of suspected onychomycosis in 183 Serbian patients
Authors: E. Dubljanin, I. Colovic Calovski, I. Vujcic, A. Dzamic, M.C. Arendrup, R.F. Petersen, R.H. Jensen
Journal: British Journal of Dermatology (2014)

Journal Article Clinical evaluation of a T. rubrum‐specific polymerase chain reaction and pandermatophyte polymerase chain reaction in the diagnosis of suspected onychomycosis in 183 Serbian patients Get access E. Dubljanin, E. Dubljanin Institute of Microbiology and Immunology Faculty of Medicine University of Belgrade Belgrade Serbia Correspondence: E. Dubljanin. Search for other works by this author on: Oxford Academic Google Scholar I. Colovic Calovski, I. Colovic Calovski Institute of Microbiology and Immunology Faculty of Medicine University of Belgrade Belgrade Serbia Search for other works by this author on: Oxford Academic Google Scholar I. Vujcic, I. Vujcic Institute of Epidemiology Faculty of Medicine University of Belgrade Belgrade Serbia Search for other works by this author on: Oxford Academic Google Scholar A. Dzamic, A. Dzamic Institute of Microbiology and Immunology Faculty of Medicine University of Belgrade Belgrade Serbia Search for other works by this author on: Oxford Academic Google Scholar M.C. Arendrup, M.C. Arendrup Unit of Parasitology and Mycology Statens Serum Institut Copenhagen Denmark Search for other works by this author on: Oxford Academic Google Scholar R.F. Petersen, R.F. Petersen Microbiological Diagnostics and Virology Statens Serum Institut Copenhagen Denmark Search for other works by this author on: Oxford Academic Google Scholar R.H. Jensen R.H. Jensen Unit of Parasitology and Mycology Statens Serum Institut Copenhagen Denmark Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 171, Issue 6, 1 December 2014, Pages 1593–1595, https://doi.org/10.1111/bjd.13168 Published: 01 December 2014
Augmented Natriuretic Response to Acute Sodium Infusion Following Blood Pressure Elevation with Metaraminol in Normotensive Subjects.
Authors: Carlos A. Vaamonde
Journal: Annals of Internal Medicine (1964)

s1 February 1964Augmented Natriuretic Response to Acute Sodium Infusion Following Blood Pressure Elevation with Metaraminol in Normotensive Subjects.Carlos A. Vaamonde, M.D., Ruben G. Lancestremere, M.D., Solomon Papper, M.D., F.A.C.P., I. Norman Sporn, M.D., Joseph L. Belsky, M.D.Carlos A. Vaamonde, M.D.Search for more papers by this author, Ruben G. Lancestremere, M.D.Search for more papers by this author, Solomon Papper, M.D., F.A.C.P.Search for more papers by this author, I. Norman Sporn, M.D.Search for more papers by this author, Joseph L. Belsky, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-321_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is well-established that patients with essential hypertension have an exaggerated natriuresis in response to acute intravenous administration of sodium. While the mechanism for this remains unknown, one of the possibilities is that elevation of blood pressure per se may cause this enhanced natriuresis.Five normotensive male subjects were studied. Three received a diet containing 150 mEq of sodium daily and 2 a diet containing 10 mEq daily. They remained recumbent from 8:00AMuntil 3:00PMand voided spontaneously at 30 minute intervals. The subjects were studied on four separate occasions. (1) "Blank day"; no manipulation was undertaken other... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Carlos A. Vaamonde, M.D.; Ruben G. Lancestremere, M.D.; Solomon Papper, M.D., F.A.C.P.; I. Norman Sporn, M.D.; Joseph L. Belsky, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1964Volume 60, Issue 2_Part_1Page: 321-321KeywordsBlood pressureDietHypertensionNatriuretic peptidesSodium ePublished: 1 December 2008 Issue Published: 1 February 1964 PDF downloadLoading ...
Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia
Authors: Meike Vogler, Michael Butterworth, Aneela Majid, Renata J. Walewska, Xiao-Ming Sun, Martin J. S. Dyer, Gerald M. Cohen
Journal: Blood (2008)
Coronary Heart Disease Incidence and Survival in African-American Women and Men: The NHANES I Epidemiologic Follow-up Study
Authors: Richard F. Gillum
Journal: Annals of Internal Medicine (1997)

Background: Relatively few data are available on risk for or survival with coronary heart disease in African-American persons. Objective: To determine whether incidence of coronary heart disease, rate of survival with the disease, and rate of coronary surgery differ between ethnic groups. Design: Prospective cohort study. Setting: United States. Participants: Persons who responded to the National Health and Nutrition Examination Survey (NHANES) I Epidemiologic Follow-up Study. Included in this analysis were 11 406 white persons and African-American persons aged 25 to 74 years who had no history of coronary heart disease. Average follow-up for survivors was 19 years (maximum, 22 years). Measurements: Incident coronary heart disease. Results: Compared with that in white persons, the age-adjusted risk for coronary heart disease was higher in African-American women aged 25 to 54 years (relative risk, 1.76 [95% CI, 1.36 to 2.29]) but was lower in African-American men within each age subgroup. The age-adjusted risk was lower in African-American men for all ages combined (25 to 74 years) (relative risk, 0.78 [CI, 0.65 to 0.93] for coronary heart disease and 0.62 [CI, 0.42 to 0.92] for acute myocardial infarction). The higher rate in African-American women aged 25 to 54 years could be explained statistically by the higher risk factor levels in these women. Ethnic groups did not significantly differ in survival after the first hospitalization for coronary heart disease. However, the incidence of coronary procedures after hospitalization for coronary heart disease was markedly lower in African-American persons than in white persons (age- and sex-adjusted relative risk, 0.40 [CI, 0.16 to 0.99]). Conclusions: Total incidence of coronary heart disease is higher in African-American women aged 25 to 54 years than in white women of the same ages and is lower in African-American men aged 25 to 74 years than in white men of the same ages.
Skin cancer: prevention is better than cure
Authors: Seau Cheung
Journal: Journal of the Royal Society of Medicine (2013)

I agree with Dr Rees1 that skin cancer is an important health issue due to its raising incidence. Although the article focuses on the management of skin cancer by surgery, there are preventive programmes and treatments to reduce the risk of developing skin cancer. These include well publicized annual sun exposure reduction programs, such as the Sun Smart campaign by Cancer Research UK and Sun Awareness by the British Association of Dermatologists. NICE has published public health guidance on skin cancer prevention.2 There is also the Sunbeds (Regulation) Act that came into force in 2011 in England and Wales that stops under-18s from using sunbeds and now recently forcible in Northern Ireland.

It is well recognized that the rising burden on managing skin cancer is related to an ageing population but there are iatrogenic causes: patients who require immunosuppressants, such as organ transplant recipients, and those with severe inflammatory dermatosis, for example psoriasis. The use of a type of phototherapy, PUVA, was cautioned in recently published NICE psoriasis guidelines in those with fairer skin types due to the long-term risk of skin cancer, worsened when systemic treatments are subsequently used.3 These patients should more vigilant to undertake sun protection measures. Furthermore, attempts to reverse skin field cancerization have also been employed, which includes the use of creams (e.g. 5-fluorouracil, imiquimod) and photodynamic therapy. Chemoprophylaxis with acitretin, a systemic retinoid, has also shown to be effective in reducing the skin cancer burden.4

As they say, ‘prevention is better than cure’, which is also an aim supported by the Institute for Innovation and Improvement.
The Legacy of World Trade Center Dust
Authors: Jonathan M. Samet, Alison S. Geyh, Mark J. Utell
Journal: New England Journal of Medicine (2007)

Interview with Robin Herbert on the health effects of the World Trade Center dust. (08:49)Download More than 5 years after the World Trade Center disaster on September 11, 2001, uncertainty and controversy remain about the health risks posed by inhaling the dust from the collapse of the twintowers, the subsequent fires, and the cleanup effort. In addition to the matter of the immediate and persistent respiratory effects on "first responders," occupants of the towers, cleanup workers, and neighborhood residents, concern has arisen about longer-term risks, including the risk of cancer. The level of concern with regard to the respiratory effects of the disaster may well be compounded by the psychological consequences. Already, some responders have . . .
Crohn's Disease: Progress Confounded
Authors: ALBERT I. MENDELOFF
Journal: Annals of Internal Medicine (1972)

Editorials1 January 1972Crohn's Disease: Progress ConfoundedALBERT I. MENDELOFF, M.D.ALBERT I. MENDELOFF, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-1-137 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the last 18 months a number of gastroenterologists have made overdue attempts (1-4) to assemble the facts about one of their most puzzling and difficult clinical problems, the peculiar form of inflammatory bowel disease known as regional enteritis or Crohn's disease. For nearly 40 years, this disorder, sometimes presenting acutely but usually insidiously, has become a more and more visible challenge to pathologists, surgeons, and internists. Cases of it were probably buried for many years among the more numerous patients with tuberculosis enteritis; now the rapid decline in prevalence of that entity has left exposed what seems to be...References1. THAYER W: Crohn's disease (regional enteritis). A look at the last four years. Scand J Gastroenterol 5 (suppl 6):165-185, 1970 Google Scholar2. MOTTET K: Histopathologic Spectrum of Regional Enteritis and Ulcerative Colitis. Philadelphia, W. B. Saunders Co., 1971, p. 249 Google Scholar3. Symposium on Crohn's disease (abridged). Proc R Soc Med 64:157-180, 1971 MedlineGoogle Scholar4. Regional enteritis (Crohn's disease), in Skandia International Symposia, edited by ENGEL A, LARSSON T. Stockholm, Nordiska Bokhandelns Förlag, 1971 Google Scholar5. KENT T, AMMON R, and DENBESTEN L: Differentiation of ulcerative colitis and Crohn's disease of the colon. Arch Pathol 89:20-29, 1970 MedlineGoogle Scholar6. ALLEN A: A unified concept of the vascular pathogenesis of enterocolitis of varied etiology. Am J Gastroenterol 55: 347-378, April 1971 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ALBERT I. MENDELOFF, M.D.Affiliations: Sinai Hospital of Baltimore Baltimore Md. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDictionary of Inorganic CompoundsIndiscretion enteritis. A rabelaisian syndromeCrohn's Disease: What Do Recurrence Rates Mean?Clinical Patterns in Crohn's Disease: A Statistical Study of 615 CasesThe Protean Manifestations of Crohn's Disease 1 January 1972Volume 76, Issue 1 Page: 137-138 Keywords Crohn's disease Enteritis Gastroenterology and hepatology Inflammatory bowel disease Pathologists Surgeons ePublished: 1 December 2008 Issue Published: 1 January 1972 PDF downloadLoading ...
Intracardiac Knotting of the Catheter during Right Heart Catheterization
Authors: JOHN F. SKINNER, JOHN T. BURROUGHS
Journal: Circulation (1961)

A complication of right heart catheterization is reported in which the catheter became knotted and entangled in the chordae tendineae of the tricuspid valve. Removal required open cardiotomy with hypothermia and temporary inflow occlusion.
Abstract 5427: Increased glycolysis by 14-3-3ζ-mediated LDHA up-regulation contributes to transformation of early mammary epithelial cells.
Authors: Chia-Chi Chang, Jia Xu, Hai Wang, Chenyu Zhang, Jian Zhang, Sumaiyah K. Rehman, Ping Li, Dihua Yu
Journal: Cancer Research (2013)

Abstract The Warburg effect is a distinct cancer hallmark that shifts the metabolic pathway in cancer cells through elevated aerobic glycolysis for energy supply and biomass. However, the mechanism of early stage metabolic dysregulation still remains unclear. 14-3-3ζ was found to be over-expressed in the early stages of breast disease and cancer (Atypical ductal hyperplasia and Ductal carcinoma in situ) and in &amp;gt;40% of breast cancer patients, correlating with poor patient prognosis. We found that 14-3-3ζ over-expression in non-transformed human mammary epithelial cells (HMECs), MCF10A and MCF12A, positively correlated with changes in the cellular glycolytic activity (increased glucose uptake, increased lactate production and reduced oxygen consumption). Additionally, 14-3-3ζ over-expression in HMECs induced soft agar colony formation and disorganized acini in three dimensional (3D) culture. Interestingly, we identified that lactate dehydrogenase A (LDHA) was up-regulated in these 14-3-3ζ overexpressing HMECs. LDHA knockdown in 14-3-3ζ overexpressing cells reduced aerobic glycolysis, decreased soft agar colonies and partially rescued the abnormal acinar structures, indicating LDHA upregulation contributed to 14-3-3ζ-mediated aerobic glycolysis and early transformation. Taken together, our data provide new insight into metabolic deregulation during the early stages of breast cancer transformation. Citation Format: Chia-Chi Chang, Jia Xu, Hai Wang, Chenyu Zhang, Jian Zhang, Sumaiyah K. Rehman, Ping Li, Dihua Yu. Increased glycolysis by 14-3-3ζ-mediated LDHA up-regulation contributes to transformation of early mammary epithelial cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5427. doi:10.1158/1538-7445.AM2013-5427
Short-term intramuscular therapy with procaine penicillin plus streptomycin for infective endocarditis due to viridans streptococci.
Authors: W R Wilson, J E Geraci, C J Wilkowske, J A Washington
Journal: Circulation (1978)

Thirty-three patients with viridans streptococcal infective endocarditis were treated for two weeks with intramuscular procaine pencillin, 1.2 million units every 6 hours, plus streptomycin, 500 mg intramuscularly every 12 hours. Nine patients (27%) had infections with relatively penicillin-resistant microorganisms (MIC greater than 0.1 microgram/ml or MBC greater than or equal 3.12 microgram/ml). Follow-up ranged from 2 months to 3.5 years. There were no relapses; Mild vestibular toxicity developed in one patient. One patient died two months after completion of antimicrobial therapy from sudden onset of severe congestive heart failure; Seven patients required cardiac valve replacement after completion of antimicrobial therapy. None died. We believe that this therapeutic regimen is effective antimicrobial therapy for infective endocarditis caused by viridans streptococci, irrespective of in vitro microbiologic data.
Abstract 19393: Decreased Insulin Secretion and Insulin Reistance in Beta 2 Adrenergic Receptor Knock-out Mice
Authors: Gaetano Santulli, Angela Lombardi, Daniela Sorriento, Antonio Anastasio, Carmine Del Giudice, Claudia Miele, Salvatore Iovino, Pietro Formisano, Bruno Trimarco, Francesco Beguinot, Guido Iaccarino
Journal: Circulation (2010)
788. Antisense Therapy for Duchenne Muscular Dystrophy: A Realistic Possibility
Authors: Qi L. Lu, Adam Rabinowitz, HaiFang Yin, Julia Alter, George Bou-Gharios, Terrence Partridge
Journal: Molecular Therapy (2005)

Duchenne Muscular Dystrophy (DMD) is the most common form of muscular dystrophy affecting 1 in every 3500 live male births. The disease is characterized by severe muscle wasting and weakness, which becomes clinically evident between the ages of 3 to 5 years. The milder form of the disease is Becker muscular dystrophy (BMD) with a spectrum of phenotypes ranging from almost asymptomatic to mild forms of DMD. Both DMD and BMD are the results of mutations in the dystrophin gene. The phenotypic distinction between DMD/BMD can be explained by the reading-frame theory where DMD is caused by frame-shifting or nonsense mutations leading to premature termination of protein synthesis whereas BMD is caused by mutations resulting in altered, but in-frame transcripts. One promising alternative approach for treatment of DMD is antisense oligonucleotide (AO)-mediated gene correction at RNA level (antisense therapy). This technique uses small oligonucleotides to correct frame-shifting or nonsense mutations by skipping a mutated exon or exons which disrupt the reading frame in such a way that restores reading frame of the dystrophin transcript. This results in the expression of a truncated, but at least partially functional dystrophin. Antisense therapy is uniquely applicable to DMD treatment for many reasons. First, the gene consists of 79 exons and muscle form of dystrophin protein can be divided into amino terminal, rod, cysteine-rich and carboxy terminal domains. However, the rod domain of the dystrophin gene appears not to be critical for its functions. Second, the majority of DMD mutations occur within this non-critical region of the dystrophin gene. Thus correction of frame-shifting mutations by skipping the mutated exon or other exons necessary for restoration of reading frame will retain critical functions of the protein. We have demonstrated that specifically designed 2'-O-methyl phosphorothioate AO (20MeAO) delivered by intramuscular injections was able to effectively skip the mutated region (exon) of the dystrophin gene in animal model of DMD with functional improvement in the muscles. Dystrophin induced by 20MeAO remains at detectable levels even 3 months after intramuscular injections. This instigated clinical trials in several countries. We now demonstrated that the AOs delivered by simple intra-venous injections can induce dystrophin expression in body-wide skeletal muscles up to therapeutic levels. The simplicity and safety of the antisense therapy provide a realistic possibility for treatment of the majority of DMD mutations.
The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer
Authors: Steven M Lipkin, Laura S Rozek, Gad Rennert, Wei Yang, Peng-Chieh Chen, Joseph Hacia, Nathan Hunt, Brian Shin, Steve Fodor, Mark Kokoris, Joel K Greenson, Eric Fearon, Henry Lynch, Francis Collins, Stephen B Gruber
Journal: Nature Genetics (2004)
Cardiac Microvascular Pathology in Fabry Disease
Authors: Beth L. Thurberg, John T. Fallon, Richard Mitchell, Thomas Aretz, Ronald E. Gordon, Michael W. O'Callaghan
Journal: Circulation (2009)

Background— In classic Fabry patients, accelerated coronary atherosclerosis and left ventricular hypertrophy manifest in the fourth decade; however, signs of cardiovascular disease also are observed later in life in “cardiac variant” patients and symptomatic female heterozygotes. These disturbances are caused by globotriaosylceramide (GL-3) accumulation in the heart resulting from lysosomal α-galactosidase A deficiency. Methods and Results— We analyzed pretreatment and posttreatment endomyocardial biopsies from 58 Fabry patients enrolled in a 5-month, phase 3, double-blind, randomized, placebo-controlled trial, followed by a 54-month open-label extension study of recombinant human α-galactosidase A. Baseline evaluations revealed GL-3 deposits in interstitial capillary endothelial cells and large, laminated inclusions within cardiomyocytes. In this study, we evaluated microvascular GL-3 clearance; no clearance of GL-3 was observed in the cardiomyocytes during this trial. Five months of recombinant human α-galactosidase A treatment in the phase 3 trial resulted in complete microvascular clearance of GL-3 from 72% of treated patients compared with only 3% of placebo patients ( P &lt;0.001). The placebo group achieved similar results after 6 months of treatment in the open-label trial. In addition, the capillary endothelium remained free of GL-3 for up to 60 months in 6 of 8 patients who consented to an end-of-study biopsy. Conclusions— The findings suggest that long-term treatment with recombinant human α-galactosidase A may halt the progression of vascular pathology and prevent the clinical manifestations of atherosclerotic disease. This histopathological study should be a useful guide for clinicians and pathologists who diagnose and follow Fabry patients.
Maternal and Neonatal Jaundice and Hepatitis Associated With Intrauterine Fetal Transfusion
Authors: Donald L. Hutchinson
Journal: JAMA (1965)

ONE OF THE most exciting innovations in clinical medicine in recent years has been the treatment, by direct transfusion, of an intrauterine fetus whose red blood cells (RBC) are affected by maternal antibodies. Several investigators throughout the world<sup>1-3</sup>have attested to the prognostic value of spectrophotometric studies of amniotic fluid, which allow for more accurate evaluation of the degree of fetal involvement. Liley further confirmed the clinical value of the analytic procedure and described a technique of fetal transfusion.<sup>4</sup> Jaundice is an infrequent complication of pregnancy. Although jaundice is common in the newborn, neonatal hepatitis is rare. This report relates the clinical histories of jaundice and hepatitis which occurred concomitantly in mother and fetus in association with intrauterine intraperitoneal fetal transfusion. Although unproved by viral identification or hepatic biopsy, it is suggested that the etiologic agent was a virus which was iatrically introduced into the fetal circulation with
The Blood Exposome and Its Role in Discovering Causes of Disease
Authors: Stephen M. Rappaport, Dinesh K. Barupal, David Wishart, Paolo Vineis, Augustin Scalbert
Journal: Environmental Health Perspectives (2014)

Since 2001, researchers have examined the human genome (G) mainly to discover causes of disease, despite evidence that G explains relatively little risk. We posit that unexplained disease risks are caused by the exposome (E; representing all exposures) and G × E interactions. Thus, etiologic research has been hampered by scientists' continuing reliance on low-tech methods to characterize E compared with high-tech omics for characterizing G.
Siah2-Dependent Concerted Activity of HIF and FoxA2 Regulates Formation of Neuroendocrine Phenotype and Neuroendocrine Prostate Tumors
Authors: Jianfei Qi, Koh Nakayama, Robert D. Cardiff, Alexander D. Borowsky, Karen Kaul, Roy Williams, Stan Krajewski, Dan Mercola, Philip M. Carpenter, David Bowtell, Ze'ev A. Ronai
Journal: Cancer Cell (2010)