tbuckley/cabot-search huggingface dataset:
UN study reports Asian economic crisis has hit women's health
Authors: J. Ciment
Journal: BMJ (1999)

A UN Population Fund report, "Southeast Asian Populations in Crisis," revealed that the economic crisis in Southeastern Asia has had a disproportionately adverse effect on the health of women and girls. This has occurred because the industries employing women have been hardest hit and because governments have reduced spending on health care and female education. Thailand, for example, has reduced its AIDS budget by 25% even as increasing numbers of women are pushed into the sex trade by economic necessity. Reproductive health services for adolescents have been hit just as shrinking family budgets are forcing adolescents to drop out of school. The report's authors are calling for a more detailed look at the situation.
Vascular Complications in Diabetes Mellitus
Authors: Joseph R. Williamson, Charles Kilo
Journal: New England Journal of Medicine (1980)

The mechanisms responsible for acceleration of atherosclerosis in diabetes mellitus and the pathophysiologic meaning of different forms of diabetic microangiopathy remain enigmatic despite considerable research aimed at elucidating the role of genetic, metabolic, and physiologic factors in the pathogenesis of vascular disease in both nondiabetics and diabetics. Particular emphasis has been given to determining whether diabetic vascular disease is modulated by metabolic, hormonal, and physiologic disturbances secondary to insulin deficiency, or by genetic factors closely linked to but independent of factors governing susceptibility to insulin insufficiency.Such studies make several points clear. First of all, insulin deficiency produced in laboratory . . .
Abstract 716: CXCR4 antagonist, CTCE-9908, inhibits PC-3 cell invasiveness and metastasis
Authors: Sreenivasa R. Chinni, Pridvi Kandagatla, Donald Wong, Walter Korz
Journal: Cancer Research (2010)

Abstract Chemokines and their receptors function in the migration and homing of cells to target tissues. Current evidence suggests that cancer cells activate chemokines and their receptors during dissemination and metastasis formation at secondary sites. Previously, in prostate cancer cells, we showed that binding of the chemokine CXCL12 to its receptor CXCR4 induced signaling events leading to MMP-9 expression, migration and invasion. CXCL12/CXCR4 transactivation of epidermal growth factor family receptors in lipid raft membrane microdomains on cell surface mediates these invasive signaling events and subsequent expansion of the skeletal metastatic deposits. Herein, we tested the efficacy of CXCR4 antagonist CTCE-9908 in prostate cancer cell growth, invasion, and metastasis. Methods: We used in vitro growth and invasion assays and in vivo orthotopic model system to asses the tumor growth and metastasis. Results: We found that (a) CTCE-9908 treatment resulted in no significant change in the growth of PC-3 cells; (b) CTCE-9908 compound at 50 μg/ml inhibited CXCL12 mediated invasion of PC-3 cells; (c) in vivo CTCE-9908 compound did not significantly altered the growth of primary tumors as measured by calipers and (d) the total tumor burden in the animal including the growth of prostate and soft tissue metastases to lymph node and distant organ tissues were significantly decreased upon CTCE-9908 administration. Histological analysis showed that CTCE-9908 treatment resulted in tumor necrosis in primary prostate tumors. Conclusions: These data suggest that CXCR4 inhibition by CTCE-9908 compound decreased the invasive signaling and metastatic spread of tumor cells without apparently affecting the primary tumor growth in animal model. Hence, CTCE-9908 is an efficacious antagonist for CXCL12/CXCR4 signaling pathway mediating invasive spread of tumor cells in secondary metastasis formation. Studies of CTCE-9908 in phase II are planned. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 716.
Moonlighter Takes on Airs: Rehydration, Aeration, Obtundation, and Education
Authors: John F. Brick
Journal: JAMA (1987)

<h3>To the Editor.—</h3> The pros and cons of house staff moonlighting have been extensively debated. We have cared for a young physician who developed a previously unreported complication from moonlighting: air embolism. <h3>Report of a Case.—</h3> AA house officer developed a flulike illness with nausea, vomiting, and diarrhea. He was scheduled to work the evening shift in a nearby community hospital emergency room and because he was worried about dehydration decided to prescribe some intravenous (IV) fluids for himself. Unable to infuse the solution during regular working hours, he drove up the interstate with the IV bag hanging from the rearview mirror of his car. Deciding that the rate of infusion was not rapid enough, he placed the bag under his leg on the car seat in hopes of increasing the rate of administration. The last thing he remembered before losing consciousness was looking down at the IV bag under
Cerebrospinal Fluid Vascular Endothelial Growth Factor
Authors: Peter T. Nelson, Gregory A. Jicha
Journal: JAMA Neurology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Lung function in children and adolescents with occasional exposure to environmental tobacco smoke.
Authors: G M Corbo, N Agabiti, F Forastiere, V Dell'Orco, R Pistelli, D Kriebel, R Pacifici, P Zuccaro, G Ciappi, C A Perucci
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

We investigated the effects of occasional exposure to environmental tobacco smoke (ETS) on lung function in children. A total of 317 healthy 12- to 15-yr-old nonsmoking children and adolescents, living in households in which none of the adults were active smokers, were selected for the present analysis. The urinary cotinine:creatinine ratio (CCR) was taken as the biologic indicator of exposure, and children were classified according to CCR quartiles. The ratio between FEV1 and FVC (FEV1/FVC) and both early (peak expiratory flow [PEF]) and midexpiratory flow rates (FEF25-75) were lower in children with higher CCR values. In percent terms, the decrease in adjusted lung function for children belonging to the second, third, and fourth quartiles in comparison with those in the first quartile was -1.37, -2.12, and -1.94 for FEV1/FVC (p for trend = 0.012); 0.98, -3.31, and -4.54 for PEF (p for trend = 0.024); and -0.05, -4.85, and -6.13 for FEF25-75 (p for trend = 0.022), respectively. The effects remained significant when possible confounding by father's education and urinary creatinine level had been taken into account, and when children whose parents' smoking status may have been misclassified were excluded. This study suggests an adverse effect on lung function from even low-level exposure to ETS among nonsmoking children living with reportedly nonsmoking parents.
Long-term consequences of Hodgkin lymphoma therapy on T-cell lymphopoiesis
Authors: Isabelle Pellier, Gilles Renier, Josué Rakotonjanahary, Marie Audrain, Elsa Berardi, Martine Gardembas, Aline Clavert, Marie Pierre Moles, Stéphanie Proust-Houdemont, Yves Reguerre, Emilie De Carli, Martine Georgin-Mege, Erwan Garo, Simon Blanchard, Charline Miot, Capucine Picard, Yves Delneste, Alain Fischer, Aline Tanguy-Schmidt, Pascale Jeannin
Journal: Journal of Allergy and Clinical Immunology (2014)
Most US hospitals lack a non-discrimination policy for same sex partners
Authors: J. H. Tanne
Journal: BMJ (2010)

Most US hospitals don’t have a non-discrimination policy giving same sex partners the same visiting and decision making rights as married partners, a survey by the Human Rights Campaign Foundation shows (www.hrc.org).

The foundation’s survey of a representative sample of US hospitals found that 93% “do not have fully inclusive policies toward LGBT [lesbian, gay, bisexual, or transgender] people and 42% don’t include ‘sexual orientation’ in their Patients’ Bill of Rights/non-discrimination policy.”

On 15 April President Barack Obama issued a memorandum calling on US hospitals …
18 DETERMINATION OF FIBROSIS STAGE AND STEATOHEPATITIS IN PATIENTS WITH NAFLD BY OPTICAL ANALYSIS OF MAGNETIC RESONANCE IMAGES COMBINED WITH ARTIFICIAL NEURAL NETWORKS (FIBROMRi AND NASHMRi)
Authors: R. Gallego-Durán, P. Cerro-Salido, E. Gómez-González, M.J. Pareja, R. Aznar, S. Macho, M.C. Rico, A. Fernández-Argüelles, E. Bugianesi, J. Crespo, R. Aparcero, I. Moreno, R. Andrade, M. Romero-Gómez
Journal: Journal of Hepatology (2013)
A TOXIC REACTION TO COMBINED ELAVIL-LIBRIUM THERAPY
Authors: FRANCIS J. KANE, TERRY W. TAYLOR
Journal: American Journal of Psychiatry (1963)

The occurrence of an acute brain syndrome with evidence of cerebellar dysfunction following the ingestion of Librium and Elavil concomitantly would seem to indicate an enhancement of the toxic effect of these drugs and would indicate extreme caution in their use together. The occurrence of similar incompatibilities among drugs used and the treatment of depression is well known and fatalities have been reported.
Access to emergency care in Palestinian West Bank: Study seems not to have been critically appraised
Authors: Elliot Brown
Journal: BMJ (2006)

EDITOR—I peer review papers for some less prestigious journals: here are some observations on the paper by Rytter et al on the effects of armed conflict on access to emergency health care in the Palestinian West Bank.1

Was this week and were these hospitals representative? Were hospitals chosen as likely to yield anticipated results (selection bias)? Was hospital admission more …
Filling-in is for finding out
Authors: Luiz Pessoa, Evan Thompson, Alva Noë
Journal: Behavioral and Brain Sciences (1998)

The following points are discussed in response to the commentaries: (1) A taxonomy of perceptual completion phenomena should rely on both phenomenological and mechanistic criteria. (2) Certain forms of perceptual completion are caused by topographically organized neural processes – neural filling-in. (3) The bridge locus, understood as the final site of perceptual experience in the brain, should be replaced by the principle that each token percept has a neural substrate that is nomically sufficient for it, all else being equal. (4) Analytic isomorphism – the view that there must be a pictorial or spatial neural-perceptual isomorphism at the bridge locus – should be rejected. Although more abstract kinds of isomorphism are central to the neural-perceptual mapping, the perceptual cannot be exhaustively explained in terms of the neural, and therefore the explanation of perception cannot be reduced to uncovering neural-perceptual isomorphisms. (5) The task of vision is to guide action in the world, not to construct a detailed world-model in the head. (6) Neural filling-in facilitates the integration of information and thereby helps the animal find out about its environment. (7) Perceptual content needs to be understood at the level of the person or animal interacting in the world.
Prevalence of Glycosuria and Diabetes Mellitus
Authors: J. Harkness
Journal: BMJ (1962)

In 1946 Wilkerson and Krall (1947) carried out the first community diabetes survey.They tested 70.60% of the population of 4,983 in Oxford, Massachusetts, and found 40 known cases of diabetes and 30 new cases.The total incidence was 1.4%,'.In Newmarket, Ontario, Kenny et al. (1951) tested 810% of the population over 6 years of age and found the incidence of diabetes to be 1.2%.They found 54 cases of diabetes, of which 21 were new cases.Since then mass screening surveys have been carried out in the United States and Canada, and in 109 surveys over Im. people have been tested.The incidence of diabetes in these surveys has varied between 1 and 1.5% (Joslin et al., 1959).In this country Redhead (1960) tested a sample of a general practice in Newcastle; 1,991 people were tested and he found 19 cases of diabetes, of which 10 were first discovered in his survey.More recently, in Ibstock, Walker and Kerridge (1961) tested 810%' of the popula- says that the highest point or peak of the curve is
New Requirements for Resident Duty Hours
Authors: Ingrid Philibert, Paul Friedmann, William T. Williams
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Troglitazone prevents and reverses dyslipidemia, insulin secretory defects, and histologic abnormalities in a rat model of naturally occurring obese diabetes
Authors: Dong Mei Jia, Akinari Tabaru, Hayato Nakamura, Ken-Ichiro Fukumitsu, Toshiharu Akiyama, Makoto Otsuki
Journal: Metabolism (2000)
Care at Birmingham Children's Hospital had "serious potential risks," says watchdog
Authors: Z. Kmietowicz
Journal: BMJ (2009)

A series of failings has been blamed for the “less than optimal care” given to patients treated at Birmingham Children’s Hospital.

An investigation by the Healthcare Commission, the health services watchdog body, found difficulties in accessing beds and theatres at the hospital, a lack of interventional radiology, poorly trained theatre staff, and a lack of communication between the trust and doctors from University Hospitals Birmingham NHS Foundation Trust, which provided some services at the hospital.

Although the commission found no evidence that patients had come to any serious harm, Anna Walker, the commission’s chief executive, said, “The standard of care has not been as good as it should have been in some cases.” She added, “While I would not say there were ‘third world’ conditions, there …
Acute electrophysiologic effects of sodium administration in dogs treated with O-desmethyl encainide.
Authors: A K Bajaj, R L Woosley, D M Roden
Journal: Circulation (1989)

Conduction slowing is the major in vivo effect of sodium channel blocking drugs. Although this action may promote arrhythmia suppression, apparently paradoxical arrhythmia aggravation does occur. The latter outcome is most frequently seen during treatment with the class IC agents such as encainide or flecainide, which are potent depressors of conduction even at usual plasma concentrations and heart rates. Anecdotal reports in patients with such drug toxicity have suggested a beneficial effect of sodium lactate or NaHCO3 administration. The purpose of this study, therefore, was to examine the changes induced by sodium loading on the electrophysiologic properties of the canine ventricle pretreated with a class IC drug. Thirty dogs received loading and maintenance infusions of O-desmethyl encainide (ODE), an encainide metabolite that as a sodium channel blocker is approximately 10 times more potent than the parent drug. Interventions were administered during the maintenance phase when stable plasma ODE concentrations of 448 +/- 68 (SEM) ng/ml were present, and QRS was prolonged from 62 +/- 1 to 89 +/- 2 msec, and HV was prolonged from 28 +/- 1 to 50 +/- 1 msec. NaHCO3 (5 meq/kg during 1 minute) shortened QRS from 92 +/- 6 to 76 +/- 3 msec and shortened HV from 44 +/- 3 to 37 +/- 3 msec within 10 minutes (both p less than 0.01). NaHCO3 also significantly prolonged endocardial monophasic action potential duration from 231 +/- 22 to 272 +/- 33 msec and decreased serum [K+] from 3.8 +/- 0.2 to 3.0 +/- 0.2 meq/l, but it did not alter plasma ODE concentration.(ABSTRACT TRUNCATED AT 250 WORDS)
Consumer representation in the NHS.
Authors: N Black
Journal: BMJ (1986)

epidemics hair analysis proved a simple, quick, practical, and accurate method ofmeasuring the body burden.8 19Such instances may recur but fortunately they are rare.In general, then, just as the feasibility of a surgical operation is no indication for its performance so the availability of an atomic emission spectroscope is no justification for feeding it with hair digests.
Original contributions by medical students: Increased fees may discourage research
Authors: A K Saggar-Malik, M A Patton
Journal: BMJ (1997)

Medical students can and do make valuable contributions to medicine when they are given the opportunity to become involved in research. Now the Medical Research Council has decided to withdraw funding for medical students opting to do an intercalated degree.

Sir James Paget (1814-99) discovered the round worm Trichinella spiralis in 1834, one year after entering St Bartholomew's Hospital Medical School. He became the first English pathologist and subsequently president of the Royal College of Surgeons in 1858. Paget contributed to many areas of medicine and has two classic descriptions of disease named …
High Levels of Platelet Inhibition With Abciximab Despite Heightened Platelet Activation and Aggregation During Thrombolysis for Acute Myocardial Infarction
Authors: Stephanie A. Coulter, Christopher P. Cannon, Kenneth A. Ault, Elliott M. Antman, Frans Van de Werf, A. A. Jennifer Adgey, C. Michael Gibson, Robert P. Giugliano, Mary A. Mascelli, Joel Scherer, Elliot S. Barnathan, Eugene Braunwald, Neal S. Kleiman
Journal: Circulation (2000)

Background —We evaluated platelet activation and aggregation in patients with acute myocardial infarction (AMI) treated with thrombolytic therapy alone or with reduced-dose thrombolysis and concomitant abciximab. Methods and Results —The study was performed in 20 control subjects and 51 patients with AMI before and after reperfusion with either alteplase or reteplase or reduced doses of these agents with concomitant abciximab. Platelet activation was assayed by platelet surface expression of P-selectin. Turbidometric platelet aggregation in response to ADP was measured in patients before thrombolytic therapy and 90 minutes and 24 hours after the beginning of thrombolytic therapy. P-selectin expression was greater at baseline in patients than normal control subjects (30.4% versus 9.8%, P &lt;0.0001) but was identical between the 2 groups after stimulation with ADP (64.4% versus 69.3%, P =0.37). However, at 24 hours, basal P-selectin expression declined in patients ( P =0.0025 versus baseline), whereas ADP-stimulated P-selectin expression was lower in patients than in control subjects (48% versus 69%, P =0.0004). When combined with reduced doses of either alteplase or reteplase, abciximab achieved 91% and 83% inhibition of 5 and 20 μmol/L ADP–induced platelet aggregation, which decreased to 46% and 40%, respectively, at 24 hours. No appreciable difference in the platelet inhibition profile of abciximab was observed between the 2 thrombolytics. Conclusions —Platelet activation and aggregation are heightened in the setting of thrombolysis for AMI. Despite this enhanced level of platelet activation, abciximab, combined with a reduced-dose thrombolytic, inhibited platelet aggregation similarly to the level reported in elective settings.
Release of Data on What Hospitals Charge Appears More Likely to Confuse Rather Than Enlighten Consumers
Authors: Mike Mitka
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal