tbuckley/cabot-search huggingface dataset:
PROGNOSTIC VALUE OF FRONTAL QRS-T ANGLE IN PREDICTING SURVIVAL AFTER PRIMARY PERCUTANEOUS CORONARY REVASCULARISATION/CORONARY ARTERY BYPASS GRAFTING FOR STEMI
Authors: Abhishek C. Sawant, Swapna R. Narra, Paul K. Mills, Sanjay Srivatsa
Journal: Journal of the American College of Cardiology (2013)
Quinine Amblyopia Related to Heroin Addiction
Authors: JOHN C. M. BRUST
Journal: Annals of Internal Medicine (1971)

A 40-year-old male heroin addict developed optic atrophy after taking large quantities of heroin diluted with quinine. Vision improved when he was placed on methadone and did not regress when he switched back to heroin without quinine. He represents the first recorded case of quinine amblyopia secondary to heroin addiction.
Value of rapid beta-blocker injectionat peak dobutamine-atropine stressechocardiography for detection of coronary artery disease
Authors: Wilson Mathias, Jeane M. Tsutsui, José L. Andrade, Ingrid Kowatsch, Pedro A. Lemos, Samira M.B. Leal, Bijoy K. Khandheria, José F. Ramires
Journal: Journal of the American College of Cardiology (2003)
Continuous Subcutaneous Insulin Infusion and Multiple Daily Injection Therapy Are Equally Effective in Type 2 Diabetes
Authors: Philip Raskin, Bruce W. Bode, Jennifer B. Marks, Irl B. Hirsch, Richard L. Weinstein, Janet B. McGill, Gregory E. Peterson, Sunder R. Mudaliar, Rickey R. Reinhardt
Journal: Diabetes Care (2003)

OBJECTIVE—Compare the efficacy, safety, and patient satisfaction of continuous subcutaneous insulin infusion (CSII) therapy with multiple daily injection (MDI) therapy for patients with type 2 diabetes. RESEARCH DESIGN AND METHODS—A total of 132 CSII-naive type 2 diabetic patients were randomly assigned (1:1) to CSII (using insulin aspart) or MDI therapy (bolus insulin aspart and basal NPH insulin) in a multicenter, open-label, randomized, parallel-group, 24-week study. Efficacy was assessed with HbA1c and eight-point blood glucose (BG) profiles. Treatment satisfaction was determined with a self-administered questionnaire. Safety assessments included adverse events, hypoglycemic episodes, laboratory values, and physical examination findings. RESULTS—HbA1c values decreased similarly for both groups from baseline (8.2 ± 1.37% for CSII, 8.0 ± 1.08% for MDI) to end of study (7.6 ± 1.22% for CSII, 7.5 ± 1.22% for MDI). The CSII group showed a trend toward lower eight-point BG values at most time points (only significant 90 min after breakfast; 167 ± 48 vs. 192 ± 65 mg/dl for CSII and MDI, respectively; P = 0.019). A total of 93% of CSII-treated subjects preferred the pump to their previous injectable insulin regimen for reasons of convenience, flexibility, ease of use, and overall preference. Safety assessments were comparable for both treatment groups. CONCLUSIONS—Insulin aspart in CSII therapy provided efficacy and safety comparable to MDI therapy for type 2 diabetes. Patients with type 2 diabetes can be trained as outpatients to use CSII and prefer CSII to injections, indicating that pump therapy should be considered when initiating intensive insulin therapy for type 2 diabetes.
Biomonitoring studies and susceptibility markers for acrolein congeners and allylic and benzyl compounds.
Authors: E Eder, C Hoffman, S Sporer, S Scheckenbach
Journal: Environmental Health Perspectives (1993)

The importance of genotoxic acrolein congeners and allylic and benzyl compounds as industrial compounds, ubiquitous environmental pollutants, and naturally occurring substances necessitates the availability of adequate biomonitoring techniques. Endogenously formed acrolein congeners are considered to play an important role in carcinogenesis. Our studies have demonstrated that acrolein congeners react with DNA components and form adducts with the guanine moiety. We have identified and characterized cyclic 1,N2-deoxyguanosine adducts, cyclic 7,8-guanine adducts, linear 7-guanine adducts, 1,N2,7,8-bis-cyclic adducts, and 1,N2-cyclic, 7-linear bis adducts. Both the reactivity of the acroleins toward nucleosides and their mutagenicity in S. typhimurium TA100 decrease with increasing degree of alkyl substitution. Adducts are now available as reference substances for developing sensitive detection methods. Of the biomonitoring methods investigated for allylic and benzyl compounds, the detection of cysteine and histidine adducts isolated from hemoglobin seems to be the most sensitive. Gas chromatography with electron capture detection of heptafluorobutyric acid derivatives allows a detection limit in the femtomole range, HPLC-fluorescence detection of O-phthalic dialdehyde derivatives allows a limit in the picomole range, and detection of 9-fluorenylmethyl-chlorofomiate derivatives allows a limit in the femtomole range.
Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures
Authors: Marianna Prokopi, Giordano Pula, Ursula Mayr, Cécile Devue, Joy Gallagher, Qingzhong Xiao, Chantal M. Boulanger, Nigel Westwood, Carmen Urbich, Johann Willeit, Marianne Steiner, Johannes Breuss, Qingbo Xu, Stefan Kiechl, Manuel Mayr
Journal: Blood (2009)
Russia fights flu outbreak
Authors: S. Jameson
Journal: BMJ (1996)

Moscow's worst flu epidemic since records began 150 years ago is moving east. Hospitals in the Russian capital have been besieged with patients with flu during the past month, and doctors estimate that before the epidemic has finally run its course more than one million Muscovites (10% of the population) will have had the illness.

Other cities across the Urals and to the …
Pituitary Apoplexy in Five Patients with Pituitary Tumours
Authors: S. Epstein, B. L. Pimstone, J. C. de Villiers, W. P. U. Jackson
Journal: BMJ (1971)

Five cases of pituitary apoplexy occurring in patients with pituitary tumours are described. This uncommon condition is characterized by headache, sudden loss of vision, alteration in the level of consciousness, and usually an abnormal cerebrospinal fluid. The whole picture may be complicated by endocrine dysfunction. The diagnosis is strengthened by a radiologically abnormal pituitary fossa and confirmed by the operative finding of haemorrhagic necrotic tissue. Surgical decompression under steroid cover offers the only hope of restoration of vision. Frequent postoperative follow-up is obligatory.
Points from Letters: Future of General Practice
Authors: J. M. Owers
Journal: BMJ (1964)

DRIISH N 779 of men in a free society would have tolerated; the position is changing rapidly with fewer doctors prepared to enter general practice and an expanding population.I hope that my fellow practitioners will grasp the opportunity provided by present events to express themselves individually and collec- tively as forcefully as possible, so that our representatives, our politicians, and the public at large shall be left in no doubt as to the feelings and desires of the active prac- titioner of the 1960's if he is to continue to work in a National Health Service.-Iam, etc., Sheffield 11.
418 UTILITY OF HISTORICAL DATA COMPARED TO LEAD-IN RESPONSE IN PREDICTING SUSTAINED VIROLOGIC RESPONSE IN NON-RESPONDERS AND RELAPSERS TO PEGINTERFERON/RIBAVIRIN WHEN RE-TREATED WITH BOCEPREVIR+PEGINTERFERON ALFA-2B/RIBAVIRIN (P/R)
Authors: R. Esteban, S. Gordon, E. Lawitz, P. Marcellin, J. Vierlin, S. Zeuzem, F. Poordad, N. Boparai, M. Burroughs, J. Albrecht, C. Brass, B. Bacon
Journal: Journal of Hepatology (2011)
The Literature of American Internal Medicine: A Historical View
Authors: W. BRUCE FYE
Journal: Annals of Internal Medicine (1987)

The literature of medicine is shaped by social and intellectual forces as well as by scientific discoveries. In America, the literature of internal medicine evolved gradually in response to changes in the structure and philosophy of medical education and the growing emphasis on research during the past century. When careers in medical education and research became possible through philanthropic and government support, Americans became more productive in research. As academic advancement came to depend primarily on publication, the literature of American internal medicine expanded dramatically. The current scope and character of the medical literature also reflect the persistent trend toward specialization and subspecialization that began more than a century ago. Although medical journals have been the most important medium for the publication of new medical knowledge for nearly 200 years, recent dramatic advances in the technology of information storage and transfer promise to undermine their primacy.
Carbohydrate Metabolism in Uremia
Authors: EDWARD S. HORTON
Journal: Annals of Internal Medicine (1968)

To define more clearly the factors involved in carbohydrate metabolism in uremia, we studied blood glucose, plasma insulin, and plasma growth hormone responses after the intravenous injections of 25 g of glucose in 17 uremic patients and compared the results with those in 14 normal subjects and 16 patients with maturity-onset diabetes mellitus. The plasma glucose response and the insulin disappearance rate after the intravenous injection of beef insulin, 0.1 unit/kg, were measured in five normal subjects and in five uremic patients with abnormal glucose tolerance. The effect of urea on glucose oxidation by adipose tissue in vitro was also studied. All but one of the uremic patients had an abnormal response to intravenous glucose (glucose decay constant (Kg) < 1.0). This was associated with a slight decrease in initial insulin secretion, continued elevation of plasma insulin levels, and decreased sensitivity of the tissues to insulin action. The persistent elevation of plasma insulin after intravenous glucose was the result of both a prolonged insulin half-life and continued stimulation of insulin secretion. By comparing the insulin/glucose ratios during the first 10 min after intravenous glucose, we could distinguish 78% of the normal and 70% of the uremic subjects from patients with maturity-onset diabetes mellitus. Insulin resistance in the uremic patients was manifested by elevated fasting plasma insulin in the presence of normal fasting blood glucose levels, high insulin/glucose ratios after intravenous glucose, and decreased blood glucose responsiveness to intravenous beef insulin. The exact mechanism of the insulin resistance in uremia remains speculative. Elevated plasma growth hormone levels were present in some, but not all, of the uremic patients, and no correlation could be made between increased growth hormone levels and impaired glucose tolerance in individual patients. It is unlikely that urea per se is the cause of the abnormal glucose tolerance in uremia, as no effect of urea on insulin-stimulated glucose oxidation by adipose tissue could be demonstrated in vitro.
Co-Occurrence of Large Leiomyoma of the Esophagus and Squamous-Cell Carcinoma of the Thymus
Authors: Howard A. Frank, Leopold Reiner, Felix G. Fleischner
Journal: New England Journal of Medicine (1956)

THIS communication describes two large, unrelated, and uncommon tumors found simultaneously in the mediastinum of a sixty-six-year-old woman. The coincidence is apparently unique, and each tumor is of interest. The first, a leiomyoma of the esophagus as large as any recorded, illustrates the atypical roentgenologic features resulting from an almost entirely extramural direction of growth. The second tumor, a carcinoma of the anterior mediastinum, poses the question of histogenesis of squamous-cell carcinoma arising in this location. Reasons are given for believing that this tumor arose in the thymus. Both tumors were resected successfully.Case ReportB.R. (B.I.H. 29155), a 66-year-old . . .
(Philip) Kevin Murphy
Authors: A. W. Murphy, P. Wright
Journal: BMJ (2012)

(Philip) Kevin Murphy was a prominent, insightful and committed public health doctor in England, Wales, the Channel Islands, and Ireland. The third youngest of seven sons and one daughter, he enjoyed a fortunate childhood in Kilrane, County Wexford. His family were at the centre of village life though entwined agriculture, general merchant, post office, and local development enterprises. He had a lifelong love of country life and things, often recalled through tales of his maiden auntie and general factotum John Whitty. He …
Insulin resistance in chronic hepatitis C, genotypes 1 and 4: The unfortunate reality
Authors: Dawn M. Torres, Stephen A. Harrison
Journal: Hepatology (2008)

BACKGROUND & AIMS: Our study was designed to test the association between insulin resistance (IR) and hepatitis C virus (HCV) genotypes, serum HCV RNA level and liver fibrosis stage in a large prospective cohort of chronic hepatitis C (CHC) patients. METHODS: Six hundred consecutive patients (CHC, n = 500; chronic hepatitis B (CHB), n = 100) were evaluated on the day of liver biopsy. IR (Homeostasis Model for Assessment of Insulin Resistance) and all components of the metabolic syndrome were assessed. By logistic regression, independent factors associated with IR and those associated with significant fibrosis were assessed in nondiabetic and noncirrhotic CHC, respectively. Parameters of IR were compared between hepatitis B and 240 CHC matched by epidemiologic, metabolic, and histologic features. RESULTS: IR was present in 32.4% of the 462 nondiabetic CHC and associated with the metabolic syndrome, genotypes 1 and 4, significant fibrosis, and severe steatosis. IR was diagnosed in 15% of 145 CHC without metabolic syndrome or significant fibrosis, and associated with genotypes 1 and 4, high serum HCV RNA level, and moderate-severe necroinflammation. Significant fibrosis was present in 51.1% of the 454 noncirrhotic CHC patients and associated with male sex, age >40 years, IR, moderate-severe necroinflammation, and severe steatosis. IR was less frequent in CHB than in matched CHC (5% vs 35%, respectively, P < .001). CONCLUSIONS: IR is a specific feature of CHC, associated with genotypes 1 and 4 and high serum HCV RNA level. Significant fibrosis is associated with IR independent from steatosis.
FDA Guideline on Women in Clinical Trials
Authors: Stuart L. Nightingale
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spermatogenesis in long-term survivors after allogeneic hematopoietic stem cell transplantation is associated with age, time interval since transplantation, and apparently absence of chronic GvHD
Authors: Alicia Rovó, André Tichelli, Jakob R. Passweg, Dominik Heim, Sandrine Meyer-Monard, Wolfgang Holzgreve, Alois Gratwohl, Christian De Geyter
Journal: Blood (2006)
Neurological Examination of Children
Authors: Kenneth R. Magee
Journal: JAMA (1967)

Although much of the material in this text is readily available in several books dealing with the neurological examination of adult patients, this is the first to emphasize techniques that are specifically adapted to children. The approach is thoroughly endorsed by Lord Brain in the foreword.  Special aspects of history-taking are considered. One chapter is devoted to particular symptoms frequently encountered in children, including clumsiness, weakness, floppiness, enuresis, pica, and deafness. In addition to the material that would obviously be expected in a presentation of the neurological examination, mental state is considered in detail, along with special tests for the recognition of minimal cerebral dysfunction. There are also sections on special investigations, including electroencephalography, electromyography, chromosomal studies, subdural taps, various roentgenographic contrast studies, audiometry, and biopsies of muscle, skin, nerve, and brain. The information is presented clearly and logically; the illustrations, some in color, are well chosen.  In view of
Neuroendocrine Tumors of the Uterine Cervix; a Retrospective Review of 16 Cases
Authors: S. Okame, K. Tomono, A. Kojima, Y. Shiroyama, K. Takehara, T. Matsumoto, T. Yokoyama, N. Teramoto, T. Nogawa
Journal: Annals of Oncology (2013)
Why are children in the same family so different from one another?
Authors: Robert Plomin, Denise Daniels
Journal: Behavioral and Brain Sciences (1987)

Abstract One of the most important findings that has emerged from human behavioral genetics involves the environment rather than heredity, providing the best available evidence for the importance of environmental influences on personality, psychopathology, and cognition. The research also converges on the remarkable conclusion that these environmental influences make two children in the same family as different from one another as are pairs of children selected randomly from the population. The theme of the target article is that environmental differences between children in the same family (called “nonshared environment”) represent the major source of environmental variance for personality, psychopathology, and cognitive abilities. One example of the evidence that supports this conclusion involves correlations for pairs of adopted children reared in the same family from early in life. Because these children share family environment but not heredity, their correlation directly estimates the importance of shared family environment. For most psychological characteristics, correlations for adoptive “siblings” hover near zero, which implies that the relevant environmental influences are not shared by children in the same family. Although it has been thought that cognitive abilities represent an exception to this rule, recent data suggest that environmental variance that affects IQ is also of the nonshared variety after adolescence. The article has three goals: (1) To describe quantitative genetic methods and research that lead to the conclusion that nonshared environment is responsible for most environmental variation relevant to psychological development, (2) to discuss specific nonshared environmental influences that have been studied to date, and (3) to consider relationships between nonshared environmental influences and behavioral differences between children in the same family. The reason for presenting this article in BBS is to draw attention to the far-reaching implications of finding that psychologically relevant environmental influences make children in a family different from, not similar to, one another.
MIF Deficiency Reduces Chronic Inflammation in White Adipose Tissue and Impairs the Development of Insulin Resistance, Glucose Intolerance, and Associated Atherosclerotic Disease
Authors: Lars Verschuren, Teake Kooistra, Jürgen Bernhagen, Peter J. Voshol, D. Margriet Ouwens, Marjan van Erk, Jitske de Vries-van der Weij, Lin Leng, J. Hajo van Bockel, Ko Willems van Dijk, Günter Fingerle-Rowson, Rick Bucala, Robert Kleemann
Journal: Circulation Research (2009)

Chronic inflammation in white adipose tissue (WAT) is positively associated with obesity, insulin resistance (IR) and the development of type 2 diabetes. The proinflammatory cytokine MIF (macrophage migration inhibitory factor) is an essential, upstream component of the inflammatory cascade. This study examines whether MIF is required for the development of obesity, IR, glucose intolerance, and atherosclerosis in the LDL receptor-deficient (Ldlr −/− ) mouse model of disease. Ldlr −/− mice develop IR and glucose intolerance within 15 weeks, whereas Mif −/− Ldlr −/− littermates are protected. MIF deficiency does not affect obesity and lipid risk factors but specifically reduces inflammation in WAT and liver, as reflected by lower plasma serum amyloid A and fibrinogen levels at baseline and under inflammatory conditions. Conversely, MIF stimulates the in vivo expression of human C-reactive protein, an inflammation marker and risk factor of IR and cardiovascular disease. In WAT, MIF deficiency reduces nuclear c-Jun levels and improves insulin sensitivity; MIF deficiency also reduces macrophage accumulation in WAT and blunts the expression of two proteins that regulate macrophage infiltration (intercellular adhesion molecule-1, CD44). Mechanistic parallels to WAT were observed in aorta, where the absence of MIF reduces monocyte adhesion, macrophage lesion content, and atherosclerotic lesion size. These data highlight the physiological importance of chronic inflammation in development of IR and atherosclerosis and suggest that MIF is a potential therapeutic target for reducing the inflammatory component of metabolic and cardiovascular disorders.
Preventing Tampering with Prescriptions: The Marton Method
Authors: PAUL R. BILLINGS
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 April 1988Preventing Tampering with Prescriptions: The Marton MethodPAUL R. BILLINGS, M.D., Ph.D.PAUL R. BILLINGS, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-4-637_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Prescribing medically indicated narcotics to known or suspected drug abusers is problematic. These patients are likely to create fictitious illnesses in order to gain prescription medications. Furthermore, these persons may tamper with prescriptions by changing the number of prescribed pills or adding to the number of refills. Fortunately, pharmacists often identify altered prescriptions and contact the prescribing physician for confirmation.In instances where there is a significant probability that prescription tampering may occur, a method for dealing with this problem is available. This technique involves failing to include a Drug Enforcement Administration number on the prescription. Because... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL R. BILLINGS, M.D., Ph.D.Affiliations: New England Deaconess Hospital Harvard Medical School Boston, MA 02215 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1988Volume 108, Issue 4Page: 637-637KeywordsAddictsDrug administrationDrugsPharmacists ePublished: 1 December 2008 Issue Published: 1 April 1988 PDF downloadLoading ...