tbuckley/cabot-search huggingface dataset:
The ACE/DD genotype is associated with the extent of exercise-induced left ventricular growth in endurance athletes
Authors: Domingo Hernández, Alejandro de la Rosa, Antonio Barragán, Ysamar Barrios, Eduardo Salido, Armando Torres, Basilio Martín, Ignacio Laynez, Amelia Duque, Antonia De Vera, Victor Lorenzo, Antonio González
Journal: Journal of the American College of Cardiology (2003)
Review: Evidence for the effectiveness of vitamin D and calcium for reducing CV outcomes, cancer, and death is limited
Authors: Joel A. Simon
Journal: Annals of Internal Medicine (2009)

Source Citation Chung M, Balk EM, Brendel M, et al. Vitamin D and calcium: a systematic review of health outcomes. Evid Rep No. 183. Rockville, MD: Agency for Healthcare Research and Quality; 2009. [PMID: Not available]
Should radiologists talk to patients?
Authors: M. Charig, F. W Wright
Journal: BMJ (1990)

the 12 000 dives surveved by us included episodes of rapid or uncontrolled ascent.For what it is worth, we have anecdotal reports of six divTing incidents relating to asthmatic divers-four in which there were rapid ascents and two in which divers developed bronchospasm underwater.In all of these cases the divers concerned surfaced safely.As medical examiners who dive we make it our business to discuss with our clients the examination, the implications of any abnormal findings, and any possible theoretical risks.We believe that this approach is adequate for medicolegal purposes.It would seem reasonable to advise people with well controlled asthma who wish to dive that they mav do so as long as they understand the theoretical risks.The real risk, if in practice there is one, would seem slight according to currently available data.Therefore the British Sub-Aqua Club's current recommendations seem adequate.
Nerve-Growth Factor in Familial Dysautonomia
Authors: Rita Levi-Montalcini
Journal: New England Journal of Medicine (1976)

I have been invited to comment on the article published in this issue on "Increased Nerve-Growth-Factor β-Chain Cross-reacting Material in Familial Dysautonomia." In view of my life-long commitment to the study of this remarkable protein molecule and of my belief that studies on nerve-growth factor will bring valuable contributions to our knowledge of basic aspects of neurosciences, as well as of inborn abnormalities and degenerative processes in the nervous system, I will consider my assignment that of the devil's advocate. In doing so, I hope to encourage further investigations, which may clarify some areas of ambiguity that blur the picture, . . .
Characterization and clinical relevance of a new complement-fixing antibod–anti-m8–in patients with primary biliary cirrhosis
Authors: Paul Weber, Judith Brenner, Ernst Stechemesser, Reinhild Klein, Ulrike Weckenmann, Günter Klöppel, Manfred Kirchhof, Volker Fintelmann, Peter A. Berg
Journal: Hepatology (1986)

A new complement-fixing antimitochondrial antibody-anti-M8-was detected in patients with primary biliary cirrhosis. Anti-M8 was only found in association with anti-M2, however, not all anti-M2 positive patients had anti-M8. Thus, among 66 anti-M2 positive patients, 29 were also positive for anti-M8, whereas sera from patients who had the complement-fixing anti-M2 and anti-M4 antibodies in parallel always strongly reacted with the M8 antigen. This group was previously described as mixed form. The M8 antigen was isolated either from human liver mitochondria or pig kidney microsomes and could be clearly distinguished from the M4 antigen. In contrast to M4, M8 was trypsin sensitive and banded at sucrose densities from 1.16 to 1.24, while M4 was found at densities from 1.08 to 1.14. Like M4, the M8 antigen also co-purified with outer mitochondrial membranes. Fifty-three patients with primary biliary cirrhosis have been followed over a period of up to 16 years and were classified according to their complement-fixing antimitochondrial antibody profile. At the time of the first diagnosis, 95% of 31 patients being anti-M2 positive, but anti-M8 negative (antimitochondrial antibody Profile I) were in Stage I or II. In contrast, only 61% of 13 patients being anti-M2 and anti-M8 positive (antimitochondrial antibody Profile II) and 44% of 9 patients with anti-M2, anti-M8 and anti-M4 in parallel (antimitochondrial antibody Profile III) belonged to Stage I or II. At the end of the observation period, only 24% of patients with antimitochondrial antibody Profile I (anti-M8 negative) had reached Stage III or IV, while 75% of patients with antimitochondrial antibody Profile II or III (anti-M8 positive) had a progression to Stage III or IV. It is concluded that the presence of complement-fixing anti-M8 antibody may herald a more progressive course of primary biliary cirrhosis.
Use of an Inspiratory Impedance Valve Improves Neurologically Intact Survival in a Porcine Model of Ventricular Fibrillation
Authors: Keith G. Lurie, Todd Zielinski, Scott McKnite, Tom Aufderheide, Wolfgang Voelckel
Journal: Circulation (2002)

Background — This study evaluated the potential for an inspiratory impedance threshold valve (ITV) to improve 24-hour survival and neurological function in a pig model of cardiac arrest. Methods and Results — Using a randomized, prospective, and blinded design, we compared the effects of a sham versus active ITV on 24-hour survival and neurological function. After 6 minutes of ventricular fibrillation (VF), followed by 6 minutes of cardiopulmonary resuscitation (CPR) with either a sham or an active valve, anesthetized pigs received 3 sequential 200-J shocks. If VF persisted, they received epinephrine (0.045 mg/kg), 90 seconds of CPR, and 3 more 200-J shocks. A total of 11 of 20 pigs (55%) in the sham versus 17 of 20 (85%) in the active valve group survived for 24 hours ( P &lt;0.05). Neurological scores were significantly higher with the active valve; the cerebral performance score (1=normal, 5=brain death) was 2.2±0.2 with the sham ITV versus 1.4±0.2 with the active valve ( P &lt;0.05). A total of 1 of 11 in the sham versus 12 of 17 in the active valve group had completely normal neurological function ( P &lt;0.05). Peak end-tidal CO 2 (P etco 2 ) values were significantly higher with the active valve (20.4±1.0) than the sham (16.8±1.5) ( P &lt;0.05). P etco 2 &gt;18 mm Hg correlated with increased survival ( P &lt;0.05). Conclusions — Use of a functional ITV during standard CPR significantly improved 24-hour survival rates and neurological recovery. P etco 2 and systolic blood pressure were also significantly higher in the active valve group. These data support further evaluation of ITV during standard CPR.
Cancer Research Campaign health education programme to promote the early detection of cutaneous malignant melanoma. I. Work-load and referral patterns
Authors: J. MELIA, E.J. COOPER, T. FROST, R. GRAHAM-BROWN, J. HUNTER, A. MARSDEN, A. VIVIER, J. WHITE, S. WHITEHEAD, A.P. WARIN, M. WROUGHTON, R. ELLMAN, J. CHAMBERLAIN
Journal: British Journal of Dermatology (1995)

From 1987 to 1989 a campaign to promote the early detection of cutaneous malignant melanoma was conducted in the areas of seven health authorities in England and Scotland (total population 3.6 million). Data were collected on 17.155 patients attending pigmented lesion clinics (PLCs) in each study area during the campaign. After a dramatic rise in PLC referral rates in the first month of the campaign the average monthly referral rate among the target population in the study period settled to an average of l3 per 105, a twofold increase compared with the pre‐campaign period. Over 85% of patients at all PLCs were seen within 4 weeks of referral from their general practitioners. The melanoma to non‐melanoma detection ratio was (1:33). The organization of future early detection initiatives needs careful review and planning, in order to improve their effectiveness in all sections of the population, and to enable health services to cope with the increased work‐toad.
Estimation of Ventricular Volumes by a Constant Infusion Indicator Dilution Technique
Authors: AARON B. SHAFFER
Journal: Circulation Research (1964)

A constant infusion indicator dilution method for estimating ventricular volumes is introduced and its feasibility demonstrated. Using this method, volumes can be calculated by two different approaches, one of which does not assume effective distribution of indicator throughout end diastolic volume ( EDV ). This offers a means of assessing the effects of nonmixing on the form of the stepwise rise in concentration of the constant infusion curve, which has relevance to the basically related stepwise decline in concentration following sudden injection of indicator. It is suggested that the degree of mixing of diastolic venous return in the previous end systolic volume ( ESV ) is basic to the distribution of indicator introduced into the ventricle. If mixing is incomplete, the site of origin of stroke volume ( SV ) from EDV is an important factor in determining the form of an indicator dilution curve and the EDV as calculated from ratios of successive concentrations. The possible range of effects of nonmixing on the form of the constant infusion curve for ventricular volume, as derived from a mathematical model, is outlined. End diastolic volumes, as estimated from ratios of successive concentrations in a series of constant infusion indicator dilution curves obtained experimentally, are tabulated, and as a group do not differ materially from those obtained by the sudden injection method.
Ly49P recognition of cytomegalovirus-infected cells expressing H2-Dk and CMV-encoded m04 correlates with the NK cell antiviral response
Authors: Agnieszka Kielczewska, Michal Pyzik, Tianhe Sun, Astrid Krmpotic, Melissa B. Lodoen, Michael W. Munks, Marina Babic, Ann B. Hill, Ulrich H. Koszinowski, Stipan Jonjic, Lewis L. Lanier, Silvia M. Vidal
Journal: The Journal of Experimental Medicine (2009)

Natural killer (NK) cells are crucial in resistance to certain viral infections, but the mechanisms used to recognize infected cells remain largely unknown. Here, we show that the activating Ly49P receptor recognizes cells infected with mouse cytomegalovirus (MCMV) by a process that requires the presence of H2-Dk and the MCMV m04 protein. Using H2 chimeras between H2-Db and -Dk, we demonstrate that the H2-Dk peptide-binding platform is required for Ly49P recognition. We identified m04 as a viral component necessary for recognition using a panel of MCMV-deletion mutant viruses and complementation of m04-deletion mutant (Δm04) virus infection. MA/My mice, which express Ly49P and H2-Dk, are resistant to MCMV; however, infection with Δm04 MCMV abrogates resistance. Depletion of NK cells in MA/My mice abrogates their resistance to wild-type MCMV infection, but does not significantly affect viral titers in mice infected with Δm04 virus, implicating NK cells in host protection through m04-dependent recognition. These findings reveal a novel mechanism of major histocompatability complex class I–restricted recognition of virally infected cells by an activating NK cell receptor.
Histological Appearances of Tumours: With a Consideration of Their Histogenesis and Certain Aspects of Their Clinical Features and Behaviour
Authors: Nancy E. Warner
Journal: JAMA (1967)

During the decade which has passed since the first edition ofHistological Appearances of Tumorswas published, this superb book has become a classic in tumor pathology. Even so, the new version surpasses the first, and those who have waited expectantly for Dr. Winston Evans' second edition will not be disappointed. In this volume all major organs of the body are included, and no major tumors are omitted. Thus the only defect of the first edition has been removed, and the value of the book is enhanced correspondingly. The amazing amount of information packed into its pages reflects Dr. Evans' extensive experience as a surgical pathologist and his special interest in embryology.  The original 35 chapters have been revised and expanded, with the addition of up-to-date, well-chosen references. Twelve new chapters have been added. Five are devoted to the reproductive system, with separate chapters on tumors of the ovary, vagina
Spanish Rh<sub>null</sub> family caused by a silent Rh gene: Hematological, serological, and biochemical studies
Authors: Carmen Pérez‐Pérez, Victor Taliano, Isabelle Mouro, Martine Huet, Antonio Salat‐Marti, Antonio Martinez, Philippe Rouger, Jean‐Pierre Cartron
Journal: American Journal of Hematology (1992)

Abstract Another example of rare red cells that failed to react with all anti‐Rh and anti‐LW antibodies was discovered in a Spanish woman suffering from a severe hemolytic anemia typical of the Rh null syndrome. Family study and Rh blood typings demonstrated clearly that the proposita was homozygous for a silent Rh gene complex (Rh null of the amorph type) that she inherited from her parents who are first cousins. Western blot analysis carried out with glycosylation‐independent antibodies directed against the Rh polypeptide and the LW glycoprotein, respectively, confirmed that these protein components were absent from the red cells of the proposita. In addition, the patient was typed U‐positive, again in agreement with the presence on her red cells of 45–75 kDa glycoproteins detected with the murine monoclonal antibody 2D10. © 1992 Wiley‐Liss, Inc.
Low molecular weight PTP–IL‐4RA interaction in atopy predisposition
Authors: N. Bottini, X.‐Q. Mao, P. Borgiani, P. Saccucci, L. Stefanini, E. Greco, L. Fontana, T. Shirakawa, J. M. Hopkin
Journal: Allergy (2002)

We recently described a protective effect of the low molecular weight protein tyrosine phosphatase (LMPTP) BC genotype, associated with the highest total enzymatic activity, against high serum IgE levels both in the English and the Italian populations. Here we test the hypothesis of a role of LMPTP in the negative modulation of IL‐4 signal transduction checking for genetic interaction between interleukin‐4 receptor alpha chain (IL‐4RA) genetic polymorphisms and LMPTP polymorphism in the predisposition to high total IgE levels in the English population. We find a significant interaction between LMPTP polymorphism and the intracellular Gln/Arg polymorphism in position 551 of IL‐4RA. Our data support the hypothesis of a direct or indirect biochemical interaction between LMPTP and IL‐4RA resulting in different modulation of IL‐4 signal transduction among joint genotypes.
POST-PARTUM POLYPOID TUMORS.
Authors: HENRY G. LANDIS
Journal: JAMA (1883)

[Read to Section on Obstetrics and Diseases of Women, June, 1883.] The title of this paper is intended to indicate that its subject-matter is concerned with tumors, 1st, which resemble polypi, more or less; and 2d, are found only after delivery. I will further restrict it to labor at full term, since the conditions after abortion differ clinically in some respects, and open too wide a field. The subject is one of great practical interest. Not infrequently the physician is accused of having left a piece of the after-birth behind—of not completing the delivery. A patient has secondary hæmorrhage or septicæmia, in the course of which are discharged or removed masses of fleshy or membranous consistence, which the old women or an unfriendly colleague pronounce to be “a bit of after-birth,” greatly to the detriment of the attending physician. I believe that, as a matter of fact, the detention of
Palindromic rheumatism in two non-identical brothers with identical HLA including DR4.
Authors: P Hannonen, M Hakola, M Oka
Journal: Annals of the Rheumatic Diseases (1985)

Two brothers, aged 52 and 44, who suffered from palindromic rheumatism (PR) for 12 and 15 years were studied. The disease remained palindromic in the older brother, while chronic deformities developed early in the course of the disease in the younger. Their identical HLA locus was A9,Aw19(29); B12,Bw22; Cw1; DR1, DR4.
Does access to cardiac investigation and treatment contribute to social and ethnic differences in coronary heart disease? Whitehall II prospective cohort study
Authors: Annie Britton, Martin Shipley, Michael Marmot, Harry Hemingway
Journal: BMJ (2004)

Objective To determine whether access to cardiac procedures and drugs contributes to social and ethnic differences in coronary heart disease in a population setting. Design Prospective study with follow up over 15 years. Civil service employment grade was used as a measure of individual socioeconomic position. Need for cardiac care was determined by the presence of angina, myocardial infarction, and coronary risk factors. Setting 20 civil service departments originally located in London. Participants 10 308 civil servants (3414 women; 560 South Asian) aged 35-55 years at baseline in 1985-8. Main outcome measures Use of exercise electrocardiography, coronary angiography, and coronary revascularisation procedures and secondary prevention drugs. Results Inverse social gradients existed in incident coronary morbidity and mortality. South Asian participants also had higher rates than white participants. After adjustment for clinical need, social position showed no association with the use of cardiac procedures or secondary prevention drugs. For example, men in the low versus high employment grade had an age adjusted odds ratio for angiography of 1.87 (95% confidence interval 1.32 to 2.64), which decreased to 1.27 (0.83 to 1.94) on adjustment for clinical need. South Asians tended to be more likely to have cardiac procedures and to be taking more secondary prevention drugs than white participants, even after adjustment for clinical need. Conclusion This population based study, which shows the widely observed social and ethnic patterning of coronary heart disease, found no evidence that low social position or South Asian ethnicity was associated with lower use of cardiac procedures or drugs, independently of clinical need. Differences in medical care are unlikely to contribute to social or ethnic differences in coronary heart disease in this cohort.
INHIBITION OF THE ANGIOTENSIN II TYPE-1 (AT-1) RECEPTOR BY THE ANGIOTENSIN RECEPTOR BLOCKER AZILSARTAN MEDOXOMIL (TAK-491) SUPPRESSES AORTIC EXPRESSION OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE-I (PAI-1) PROTEIN IN TRANSGENIC MICE OVEREXPRESSING PAI-1 IN VASCULAR SMOOTH MUSCLE CELLS
Authors: Christopher French, Patricia Baumann, Dagnija Neimane, Keara McElroy-Yaggy, Tarikuz Zaman, Burton Sobel
Journal: Journal of the American College of Cardiology (2011)
Streptokinase in Chronic Arterial Occlusive Disease
Authors: Michael Martin
Journal: JAMA (1970)

Infusions of streptokinase can be of value in chronic arterial occlusive disease, if certain criteria are observed. Most promising are stenoses of the abdominal aorta, common iliac artery, and external iliac artery. In some cases where conditions do not allow vascular surgery, streptokinase may be used in an attempt to restore blood flow through the obliterated vessel. Localization of the obstruction in the common iliac artery seems to be most favorable in these cases. Further studies, particularly on the duration of the results of successful thrombolytic treatment, are necessary.
Scott-Brown's Otolaryngology
Authors: Robert Thayer Sataloff
Journal: JAMA (1989)

<i>Scott-Brown's Otolaryngology</i>, fifth edition, edited by Alan G. Kerr, is a monumental, six-volume otolaryngology text. It has been a standard work among British otolaryngologists since 1952 and is respected highly by otolaryngologists throughout the world. The new edition is two volumes longer than the fourth edition owing to the inclusion of a volume on pediatric otolaryngology and a separate volume on the ear. The additional materials covered, and updating of subjects addressed in previous editions, render this text current and authoritative in most aspects. Its British origins produce a slightly different slant and minor practice differences when compared with standard, multivolume American otolaryngology texts such as<i>Otolaryngology-Head and Neck Surgery</i>, edited by C. W. Cummins, C. J. Krause, D. E. Schuller, J. M. Fredrickson, and L. A. Harker (CV Mosby, 1986), and<i>Otolaryngology—Head and Neck Surgery</i>, edited by M. M. Paparella and D. A. Shumrick (WB Saunders, 1980). Like these
Perception of breathlessness during bronchoconstriction induced by antigen, exercise, and histamine challenges.
Authors: H Turcotte, F Corbeil, L P Boulet
Journal: Thorax (1990)

Perception of breathlessness was studied in eight patients with mild, stable asthma after a histamine and exercise challenge performed before and 24 and 48 hours respectively after an antigen challenge. FEV1 and perception of breathlessness, evaluated by Borg9s 10 point category scale, were measured after each administration of doubling antigen or histamine concentrations to achieve a greater than 20% fall in FEV1, and after six minutes of steady state exercise at 80% of maximal oxygen consumption (VO2max). The geometric mean provocative concentration of histamine causing a 20% fall in FEV1 (PC20) fell from 1.67 mg/ml before antigen challenge to 0.52 mg/ml 24 hours after the challenge. The median maximal % fall in FEV1 with exercise was 24.9% (range 10.5-40.5%) before and 30.6% (range 13.8-52.3%) 48 hours after antigen challenge. The median maximum % fall in FEV1 after antigen inhalation was 20.1% (range 13.3-35.2%) within the first hour; only two subjects had a late fall in FEV1 (23% and 58%). The median (range) of Borg scores obtained when FEV1 was reduced by 20% did not differ significantly for the three types of acute challenges: 1.25 (0.5-2.5) and 1.0 (0.5-3.0) after histamine tests, 1.0 (0.5-4.1) and 1.55 (0.5-2.0) after exercise, and 1.5 (0-3.0) after antigen challenge. In the two subjects who had a late response to antigen the Borg score was reduced for the same % fall in FEV1 as with the early response. It is concluded that the perception of breathlessness does not differ appreciably during the early response to histamine, antigen exposure, or exercise, but that it is reduced during the late asthmatic response. It was not influenced by previous antigen exposure, despite an increase in airway responsiveness.
Contrast-enhanced ultrasound of histologically proven liver hemangiomas
Authors: Christoph F. Dietrich, Joachim C. Mertens, Barbara Braden, Gudrun Schuessler, Michaela Ott, Andre Ignee
Journal: Hepatology (2007)

Differentiation of small and atypical hemangiomas from other hepatic masses using imaging methods can be difficult, especially in patients with underlying malignant disease. Therefore, contrast-enhanced ultrasound was assessed in patients with histologically confirmed hemangiomas with respect to contrast-enhancing kinetics and tumor characteristics. In 58 patients with indeterminate hepatic lesions demonstrated with at least 2 imaging methods (ultrasound/computed tomography/magnetic resonance imaging), ultrasound-guided liver biopsy revealed hemangioma. In all patients a hepatic neoplasm had been suspected because of underlying malignant disease (n=41), liver cirrhosis (n=15), or growth of the lesion (n=2). All patients underwent nonlinear, low mechanical index real-time contrast-enhanced ultrasound scanning with bolus injections of SonoVue. Peripheral nodular arterial enhancement was detected in 43 patients (74%), whereas the typical metastatic peripheral rim-like enhancement was not observed at all. Strong homogenous arterial enhancement was found in 9 of 58 (16%) patients. In 6 patients (10%), the arterial contrast enhancement pattern could not be determined because of the very small size of the lesions or fibrotic nodules. Forty-five (78%) of the hemangiomas showed homogenous centripetal filling within 180 seconds. Contrast-enhanced ultrasound demonstrates typical hemangioma imaging characteristics, that is, peripheral nodular contrast enhancement and iris-diaphragm sign in a high percentage of patients with undetermined lesions. This technique may therefore improve noninvasive functional characterization and differentiation of hemangiomas.