Cystatin C, Serum Creatinine, and Estimates of Kidney Function: Searching for Better Measures of Kidney Function and Cardiovascular Risk
Authors: Adeera Levin
Journal: Annals of Internal Medicine (2005)

Editorials5 April 2005Cystatin C, Serum Creatinine, and Estimates of Kidney Function: Searching for Better Measures of Kidney Function and Cardiovascular RiskAdeera Levin, MDAdeera Levin, MDFrom University of British Columbia, St. Paul's Hospital, Vancouver, British Columbia, V6Z 1W8 Canada.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-7-200504050-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Because kidney dysfunction is associated with adverse cardiovascular outcomes and death, clinicians are beginning to realize that accurately detecting even modest reductions in kidney function could help to identify patients who need extra attention.Why is it important to identify early-stage kidney dysfunction accurately? Reduced kidney function is associated with increased incidence of cardiovascular morbidity and mortality in large cohorts of both selected and unselected patients (1, 2). This finding has led to the hypothesis that earlier recognition of kidney disease and successful intervention may improve outcomes of cardiovascular disease (CVD). No studies to date have determined the mechanism by ...References1. Anavekar NS, McMurray JJ, Velazquez EJ, Solomon SD, Kober L, Rouleau JL, et al. Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction. N Engl J Med. 2004;351:1285-95. [PMID: 15385655] CrossrefMedlineGoogle Scholar2. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351:1296-305. [PMID: 15385656] CrossrefMedlineGoogle Scholar3. Muntner P, Hamm LL, Kusek JW, Chen J, Whelton PK, He J. 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[PMID: 15477399] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Adeera Levin, MDAffiliations: From University of British Columbia, St. Paul's Hospital, Vancouver, British Columbia, V6Z 1W8 Canada.Disclosures: None disclosed.Corresponding Author: Adeera Levin, MD, Division of Nephrology, University of British Columbia, St. Paul's Hospital, 1081 Burrard Street, Providence Wing, Room 6010A, Vancouver, British Columbia, V6Z 1W8 Canada; e-mail, [email protected]bc.ca. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCystatin C Concentration as a Risk Factor for Heart Failure in Older Adults Mark J. Sarnak , Ronit Katz , Catherine O. Stehman-Breen , Linda F. Fried , Nancy Swords Jenny , Bruce M. Psaty , Anne B. Newman , David Siscovick , Michael G. 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