tbuckley/cabot-search huggingface dataset:
Personal Computer Programs to Assist with Self-Monitoring of Blood Glucose and Self-Adjustment of Insulin Dosage
Authors: Nat L Pernick, David Rodbard
Journal: Diabetes Care (1986)

We have developed computer programs in compiled BASIC for the IBM-PC and compatible microcomputers for use by physicians, paramedical personnel, and/or patients to assist with self-monitoring of blood glucose (SMBG) and self-adjustment of insulin dosage. The programs can potentially assist with patient education and motivation, and provide: a customized "electronic notebook" for storage and retrieval of information on blood glucose, insulin dosage, hypoglycemic reactions, urinary ketones, diet, activity, weight, illness, apparent explanations for hypoglycemic reactions or glucose values outside target ranges, and comments; graphic displays of glucose and insulin versus date, and of a "glucose profile" versus time of day or versus day of the week; simple and detailed statistical analyses; a legible summary of data; a facility to permit the physician to prepare a "customized treatment plan" for each patient, involving a choice of six regimens, target levels for each of eight time periods, four supplement tables (when well or sick, before meals, or at bedtime), rules to reduce insulin in response to hypoglycemic reactions or documented hypoglycemia, rules to increase routine insulin doses in response to persistent unexplained hyperglycemia, and rules when the patient should call the physician; suggestions regarding compensatory supplements and adjustments of routine insulin dosage; explanations why various insulin dosages should or should not be altered, and why various glucose values should be tested; comparisons of the insulin dosage administered by the patient and the recommendations of the program, together with explanations for discrepancies offered by the patient, to help evaluate compliance. The program is "user-friendly," easy to learn, and easy to use.(ABSTRACT TRUNCATED AT 250 WORDS)
A Combination of Congenital Anomalies
Authors: I. Kessel
Journal: BMJ (1952)

ANGIOMA VENOSUM RACEMOSUMIBIUr?e tumours arise from a developmental fault of the central nervous system, so these lesions may occur in any of the organs innervated by filaments from that neuromere.Appreciation of the skin naevi in this case enabled a correct pre-operative diagnosis to be made.Summary A case is described of angioma venosum racemosum of the cervical spinal cord associated with angiomata of the omentum and skin naevi of the same metameres.The diagnostic value of the cutaneous lesions is stressed.I wish to thank Dr.
The Smokeless Pipe
Authors: N. J. Holter
Journal: JAMA (1970)

To the Editor:—  As an alternative, or perhaps an adjunct under certain conditions, to The Smokeless Pipe, how about a special pipe to be used by the nonsmoker in the presence of tobacco smoke from others? I propose a pipe with a large enough bowl and a stem with an adequate lumen to provide an adequate air flow through a mass of smoke-absorbent material, so that the nonsmoker could be a mouth breather, exhaling through the nose, until he could locate a better environment. He would not look as conspicuous as if he wore a gas mask. A possible deleterious side effect might be that he would be looked upon by other nonsmokers as the culprit.
Selective Expansion of Marginal Zone B Cells in Eμ-API2-MALT1 Mice Is Linked to Enhanced IκB Kinase γ Polyubiquitination
Authors: Mathijs Baens, Sabine Fevery, Xavier Sagaert, Heidi Noels, Sofie Hagens, Vicky Broeckx, An D. Billiau, Christiane De Wolf-Peeters, Peter Marynen
Journal: Cancer Research (2006)

Abstract The translocation t(11;18)(q21;q21) that generates an API2-MALT1 fusion protein is the most common structural abnormality among the genetic defects reported in mucosa-associated lymphoid tissue (MALT)-type lymphomas, and its presence correlates with the apparent lack of further genetic instability or chromosomal imbalances. Hence, constitutive nuclear factor-κB (NF-κB) activation induced by the API2-MALT1 fusion protein is considered essential for B-cell transformation. To examine its role in B-cell development and lymphomagenesis, Eμ-API2-MALT1 transgenic mice were produced. Our data show that expression of the API2-MALT1 fusion protein alone is not sufficient for the development of lymphoma masses within 50 weeks. Nevertheless, API2-MALT1 expression affected B-cell maturation in the bone marrow and triggered the specific expansion of splenic marginal zone B cells. Polyubiquitination of IκB kinase γ (IKKγ), indicative for enhanced NF-κB activation, was increased in splenic lymphocytes and promoted the survival of B cells ex vivo. In addition, we show that the API2-MALT1 fusion resided in the cholesterol- and sphingolipid-enriched membrane microdomains, termed lipid rafts. We provide evidence that association of the MALT1 COOH terminal with the lipid rafts, which is mediated by the API2 portion, is sufficient to trigger NF-κB activation via enhanced polyubiquitination of IKKγ. Taken together, these data support the hypothesis that the API2-MALT1 fusion protein can contribute to MALT lymphoma formation via increased NF-κB activation. (Cancer Res 2006; 66(10): 5270-7)
New technology for chromosome analysis
Authors: B. Merz
Journal: JAMA (1983)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Early remission is associated with improved survival in patients with inflammatory polyarthritis: results from the Norfolk Arthritis Register
Authors: Carlo A Scirè, Mark Lunt, Tarnya Marshall, Deborah P M Symmons, Suzanne M M Verstappen
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> This study aimed to evaluate whether the early achievement of clinical remission influences overall survival in an inception cohort of patients with inflammatory polyarthritis (IP). <h3>Methods</h3> Consecutive early IP patients, recruited to a primary care based inception cohort from 1990 to 1994 and from 2000 to 2004 were eligible for this study. Remission was defined as absence of clinically detectable joint inflammation on a 51-joint count. In sensitivity analyses, less stringent definitions of remission were used, based on 28-joint counts. Remission was assessed at 1, 2 and 3 years after baseline. All patients were flagged with the national death register. Censoring was set at 1 May 2011. The effect of remission on mortality was analysed using the Cox proportional hazard regression model, and presented as HRs and 95% CIs. <h3>Results</h3> A total of 1251 patients were included in the analyses. Having been in remission at least once within the first 3 years of follow-up was associated with a significantly lower risk of death: HR 0.72 (95% CI 0.55 to 0.94). Patients who were in remission 1 year after the baseline assessments and had persistent remission over time had the greatest reduction in mortality risk compared with patients who never achieved remission within the first 3 years of follow-up: HR 0.58 (95% CI 0.37 to 0.91). Remission according to less stringent definitions was associated with progressively lower protective effect. <h3>Conclusions</h3> Early and sustained remission is associated with decreased all-cause mortality in patients with IP. This result supports clinical remission as the target in the management of IP.
REMOTE EFFECTS OF BONE TRAUMA.
Authors: D. S. FAIRCHILD
Journal: JAMA (1897)

Some experiences during the past few years has suggested the subject of this paper, and I have in consequence examined a considerable range of medical literature for the purpose of obtaining data upon which to base certain propositions. The result is somewhat disappointing for the reason that writers, even those standing highest as authorities, have written but little in reference to the remote consequences of bone injury, especially in relation to such cases as may become the subject of controversy. Exception must be made of the writings of those who before the discovery of the special cause of tuberculosis regarded certain classes of joint disease and certain cases of osteomyelitis as the resultof injury more or less remote, recognized or assumed The effects of injuries upon the future condition of bone tissue are so varying in their nature that it would be quite impossible to predicate the future possibilities in
Ga-67 SPECT in Primary Gastroesophageal Malignant Melanoma
Authors: SEIGO KINUYA, NORIHISA TONAMI, KINICHI HISADA
Journal: Clinical Nuclear Medicine (1996)

Primary gastroesophageal malignant melanoma is extremely rare, although metastatic melanoma to the gastrointestinal tract is commonly found. A 65-year-old woman with pathologically proven primary gastroesophageal melanoma was examined with Ga-67 SPECT. Malignant melanoma, as well as malignant lymphoma, should be considered when intense Ga-67 uptake is found in gastroesophageal lesions.
Gastrointestinal motility and glycemic control in diabetes: the chicken and the egg revisited?
Authors: Christopher K. Rayner, Michael Horowitz
Journal: Journal of Clinical Investigation (2006)

Upper gastrointestinal dysfunction occurs frequently in diabetes and potentially contributes to both abdominal symptoms and impaired glycemic control; conversely, variations in blood glucose concentration reversibly affect gut motility in humans. In this issue of the JCI, Anitha et al. report apoptosis of rodent enteric neurons under hyperglycemic conditions, both in vitro and in vivo, associated with impaired PI3K activity and preventable by glial cell line–derived neurotrophic factor. These observations add to recent insights gained from animal models regarding the etiology of diabetic gastrointestinal dysfunction, but investigators must strive to translate animal data to human diabetes.
ENDOTRACHEAL ANESTHESIA FOR TONSILLECTOMY AND ADENOIDECTOMY IN CHILDREN
Authors: John W. Pender
Journal: JAMA (1953)

The use of endotracheal methods of anesthesia has been widely accepted for adults. For children, such methods are standard in many operations, especially those about the head and neck, such as craniotomy and cleft palate. The use of endotracheal anesthesia for tonsillectomy and adenoidectomy in children has gained favor slowly in spite of its being the routine method of general anesthesia for tonsillectomy in adults in many hospitals. We believe that the advantages of endotracheal anesthesia for tonsillectomy and adenoidectomy are as great for children as for adults, if not greater, and in our experience the disadvantages have been encountered no more frequently and they have been of no greater magnitude in children than in adults.  ADVANTAGES  The endotracheal tube serves as an airway that is continuously patent in contrast to the frequent obstruction to respiration that occurs during tonsillectomy when an endotracheal tube is not used. A continuously patent
New ideas on the pathophysiology and treatment of lung disease
Authors: D F Rogers, G J Laurent
Journal: Thorax (1998)

There is a continuing need for development of new treatments for lung disease. Basic scientific investigations are identifying novel targets for the development of new approaches to therapy of a range of respiratory conditions. Coupled with the advances in technology being harnessed by the pharmaceutical and biotechnological industries, there is now an impressive range of potential treatments including gene therapy, not just for cystic fibrosis but also for a range of inflammatory lung conditions, anti-cytokine and anti-adhesion molecule approaches, and targeting of intracellular signal transduction pathways including cyclic AMP metabolism, tyrosine kinases and MAP kinases. "Old" molecules such as heparin and secretory leukoprotease inhibitor (SLPI) are demonstrating new beneficial activities. Simple molecules such as nitric oxide (NO) gas may be involved in the pathophysiology of different airway conditions. It is an exciting time for respiratory science and a time for optimism for those seeking new approaches to the treatment of lung diseases.
Haemorrhage from the Organs of Generation during Pregnancy and Parturition
Authors: A. V. Macan
Journal: BMJ (1880)

UNDER the short and apparently simple title of "Haemorrhage from the Organs of Generation during Pregnancy and Parturition" are in- cluded a number of the most tlistinct and separate affections, which, though capable of generalisation under the common symptom "hzemor- rhage", bear no sort of family resemblance to each other, and are, there- fore, 'extremely difficult to treat of under onecommon head.This will, I think, be obvious, by a simple enumeration of the various subjects that are embraced by the above definition.They are- i. Menstruation during pregnancy.2. Irregular, or periodic, non-menstrual discharges (erosion, polypus, carcinoma).3. Abortion and miscarriage, includinig the various forms of moles and hydatitis.4. Accidental hDemnorrhage.5. Unavoidable bhemorrhage.6. Other forms of hccimorrhage occurring during labour.from rupture of the uterus, thrombus, or velamentous insertion of the cord.7. Post fiar-tum hhemorrhage, both from the site of the placenta (in- cluding acute inversion of the uterus), and that due to rupture of the cervix, vagina, or external genitals; and in some rare cases, even from the rectum.It is manifestly impossible to treat all these subjects, even super- ficially, within the limits which have been very properly assigned to all communications read at these meetings.I have not, therefore, essayed the tas'K, but will confine the observations I have to make to the fol- lowing subjects.i.The occurrence of menstruation during pregnancy.2. The symptoms that justify us, in a case of threatened abortion, in ceasing all further efforts to save the ovum.3. The treatment of imperfect abortion.4. The treatment of placenta przevia.5. The prevention and treatment of post fia;-tum hhemorrhage, espe- cially that described by Gooch as "a peculiar form of hnmorrhage".I .Amnong rccent writers, there is a singular unanimity as to the possi- bility of menstruation occurring in a pregnant woman.Montgomery, in his book on the Szz-ns anzd 9Sy,mptooms of Pr-egnzancy (page 85), gives instances of its occurring, not only once or twice after conception, but even continuing during the whole pregnancy, and quotes Deventer, Dewees, and Baudelocque, as authorities for the fact that some women menstruate only duiring pregnancy.There can be nu doubt that
Epidemiology of Motor-Neuron Diseases
Authors: A. Roger Bobowick, Jacob A. Brody
Journal: New England Journal of Medicine (1973)

THE motor-neuron diseases as considered here include the clinical syndromes that have been shown to be due to primary abnormalities of anterior-horn cells and motor cranial-nerve nuclei. The term motor-neuron disease is used in a more restricted sense for the syndrome of amyotrophic lateral sclerosis and the clinical components, progressive muscular atrophy and progressive bulbar palsy. Although these disorders have a similar pathologic substrate and clinical expression, they do not necessarily share the same causal factors. Some are clearly hereditary, and amyotrophic lateral sclerosis is sporadic in 95 per cent of cases.In recent years, the distinctions between the major . . .
Perspectives on Hepatitis B Vaccination
Authors: Burton A. Waisbren
Journal: JAMA (1997)

<h3>To the Editor.</h3> —I read with interest and appreciation the recent Landmark Perspective and the discussion regarding the hepatitis B vaccine by Dr Douglas.<sup>1</sup>However, I find it somewhat disturbing that Douglas did not mention the potential untoward results of viral vaccines, or those already reported as presumably being due to the hepatitis B vaccine. Douglas must be aware of the untoward results from the vaccine, not only because of lawsuits his company has settled in which demyelinating disease was involved, but also because of reports of adverse reactions linked to vaccine use in the medical literature,<sup>2-4</sup>including multiple sclerosis—like diseases, Guillain-Barré syndrome, optic neuritis, and transverse myelitis. Despite these reports, the strategy of universal vaccination in the United States has been promoted widely by Merck, the Centers for Disease Control and Prevention, and others.<sup>5,6</sup>Should not the parents of infants be made aware of the potential
Hydroxyethyl starch and modified fluid gelatin maintain plasma volume in a porcine model of septic shock with capillary leakage
Authors: G. Marx, M. Cobas Meyer, T. Schuerholz, B. Vangerow, K. Gratz, H. Hecker, R. Sümpelmann, H. Rueckoldt, M. Leuwer
Journal: Intensive Care Medicine (2002)
Changes in systemic vascular resistance detected by the arterial resistometer: preliminary report of a new method tested during percutaneous transluminal coronary angioplasty.
Authors: R Mohr, S Rath, O Meir, A Smolinsky, Y Har-Zahav, H N Neufeld, D A Goor
Journal: Circulation (1986)

A recently developed apparatus provides on-line continuous monitoring of systemic vascular resistance (SVR) by means of simple computer analysis of the peripheral arterial waveform. The fundamental equation of this method is Ri = P'/(dP/dt), where dP/dt is the peak dP/dt of the peripheral arterial waveform, P' is the pressure at time of peak dP/dt, and Ri is a resistance index that bears a direct relation to SVR. Eleven patients undergoing percutaneous transluminal coronary angioplasty (PTCA) were studied to evaluate the changes in SVR associated with myocardial ischemia (angina detection). There were 49 balloon inflations, all of which were associated with an increase in Ri (from 38.4 +/- 12 to 81.2 +/- 36 X 10(-3) sec; p less than .01) and a decrease in dP/dt (from 2076 +/- 257 to 1327 +/- 326 mm Hg/sec; p less than .01). In 42 of the balloon inflations these changes were associated with electrocardiographic ST-T changes and in 23 it was also associated with anginal pain. When angina was present, a further increase in Ri (to 97.5 +/- 43 X 10(-3) sec; p less than .01) and a decrease in dP/dt (to 1218 +/- 338 mm Hg/sec; p less than .01) was observed. It was found that myocardial ischemia is associated with an increase in the resistance index and a decrease in dP/dt and can be detected by the resistometer.
Oral 10, Childhood mucous membrane pemphigoid: successful control with mycophenolate mofetil monotherapy
Authors: A.S. Alkali, A. Bharati, P.D. Yesudian, R.A.G. Parslew, A. Field
Journal: British Journal of Dermatology (2007)

Journal Article Oral 10, Childhood mucous membrane pemphigoid: successful control with mycophenolate mofetil monotherapy Get access A.S. Alkali, A.S. Alkali Department of Dermatology, Broadgreen Hospital, Liverpool; Department of Dermatology, Countess of Chester Hospital, Chester; Search for other works by this author on: Oxford Academic Google Scholar A. Bharati, A. Bharati Department of Dermatology, Broadgreen Hospital, Liverpool; Department of Dermatology, Countess of Chester Hospital, Chester; Search for other works by this author on: Oxford Academic Google Scholar P.D. Yesudian, P.D. Yesudian Department of Dermatology, Broadgreen Hospital, Liverpool; Department of Dermatology, Countess of Chester Hospital, Chester; Search for other works by this author on: Oxford Academic Google Scholar R.A.G. Parslew, R.A.G. Parslew Department of Dermatology, Broadgreen Hospital, Liverpool; Department of Dermatology, Countess of Chester Hospital, Chester; Search for other works by this author on: Oxford Academic Google Scholar A. Field A. Field Department of Dermatology, Broadgreen Hospital, Liverpool; Department of Dermatology, Countess of Chester Hospital, Chester; Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 156, Issue 6, 1 June 2007, Page 1406, https://doi.org/10.1111/j.1365-2133.2007.07876_10.x Published: 01 June 2007
How to measure renal function in clinical practice: Age affects estimated glomerular filtration rate
Authors: Sunil Bhandari
Journal: BMJ (2006)

EDITOR—I read the overview by Traynor et al regarding how to measure renal function.1 Especially for primary care doctors, an abnormal estimated glomerular filtration rate in patients older than 70 may be normal and estimates below an MDRD (modification of …
Biomarkers for assessing reproductive development and health: Part 1--Pubertal development.
Authors: John C Rockett, Courtney D Lynch, Germaine M Buck
Journal: Environmental Health Perspectives (2003)

The proposed National Children's Study has helped raise awareness of the issues related to children's health and the importance of monitoring the growth and development of children from preconception through adulthood. Many genetic predispositions can adversely impact the normal development process, and various environmental exposures have been linked to adverse reproductive health in rodent models and a small number of accidental human exposures. To monitor reproductive health and identify adverse effects at the earliest possible juncture, investigators must develop a network of biomarkers covering all stages and aspects of reproductive development and function. Biomarkers are biological indicators that can be measured repeatedly and are informative on one or more aspects of biological development or function. They can range from the anatomical level down to the molecular level and may provide information on the nature of an exposure, the effect of an exposure, or the susceptibility of individuals or populations to the toxic effects of an exposure. In theory, biomarkers can be used to monitor a wide variety of conditions and responses ranging from abnormal development to early indicators of late-onset disease. The main stumbling block with this theory has been finding appropriate biomarkers for particular conditions and exposures. Such biomarkers must be easily accessible, robust, and sensitive. Ideally, they will be expressed across a large section of the population, and can be monitored quickly, easily, conveniently, and with minimal cost. In this review, we discuss some of the current and emerging biomarkers of human pubertal development.