tbuckley/cabot-search huggingface dataset:
Oxidized Low-Density Lipoprotein Augments and 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Limit CD40 and CD40L Expression in Human Vascular Cells
Authors: Uwe Schönbeck, Norbert Gerdes, Nerea Varo, Rebecca S. Reynolds, Daniel B. Horton, Udo Bavendiek, Linda Robbie, Peter Ganz, Scott Kinlay, Peter Libby
Journal: Circulation (2002)

Although CD40 signaling participates in atherosclerosis, links between lipid risk factors and this inflammatory pathway remain obscure. Cardiovascular risk reduction by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) may involve actions beyond lipid lowering, including reduced inflammation. Therefore, this study analyzed whether oxidized low-density lipoprotein (oxLDL) induces CD40/CD40L expression on cells implicated in atherogenesis and whether statins affect their expression in vitro as well as the expression of soluble CD40L (sCD40L) in vivo.Treatment of human vascular endothelial and smooth muscle cells and mononuclear phagocytes with oxLDL augmented the basal expression of CD40 and CD40L mRNA and protein. In contrast, cerivastatin, atorvastatin, or simvastatin concentration-dependently diminished the constitutive as well as oxLDL- or cytokine-induced expression of the receptor/ligand dyad, an effect reversed by mevalonate. Patients treated with statins had diminished sCD40L plasma levels compared with untreated control patients (8.3+/-3.1 ng/mL [n=11] versus 13.1+/-2.5 ng/mL [n=16], P<0.05), supporting the clinical relevance of the in vitro observations. Platelet-enriched plasma of mice deficient in CD40L showed markedly delayed fibrin clot formation, suggesting a role for the ligand in blood coagulation and supporting the hypothesis that statin-mediated reduction in CD40/CD40L expression might limit thrombosis.OxLDL may promote expression of CD40 and CD40L in human atheroma. Statins may limit the expression of the CD40 receptor/ligand dyad in two ways, directly as well as through diminished lipoprotein levels. Thus, reduced CD40 signaling may account for some of the statins' antiinflammatory action.
540 A COMPENSATORY ANTI-INFLAMMATORY RESPONSE SYNDROME (CARS) TRIGGERED BY NEUTROPHIL-INDUCED OXIDATIVE STRESS IS ASSOCIATED WITH CHRONIC LOW GRADE HEPATIC ENCEPHALOPATHY IN PATIENTS WITH ADVANCED CIRRHOSIS
Authors: N.J. Taylor, R.D. Abeles, Y. Ma, J.A. Wendon, D.L. Shawcross
Journal: Journal of Hepatology (2010)
Exercise and Intermittent Claudication
Authors: JAMES S. SKINNER, D. EUGENE STRANDNESS
Journal: Circulation (1967)

Four men with arteriosclerosis obliterans (ASO) were exercised on a treadmill on 4 different days to determine their maximal walking time (MWT) and the point at which their claudication pain (CPT) began. Each subject was exercised at 60%, 75%, and 90% of his MWT to determine the effect of work intensity on the systolic blood pressure at the ankle (AP). To measure the effect of exercise repeated on the same day, each subject walked five times each day on 4 different days at each of the three workloads. After each subject completed the required number of walks, his MWT was again measured on 4 separate days (one subject was retested only once) to determine whether it had changed. In every case the greatest reduction in AP occurred after the initial maximal walk but the submaximal intensities caused different responses in the different subjects. With repetition of exercise each subject displayed a progressive increase in either the AP level taken 2 minutes postexercise or the rate of recovery of AP to the pre-exercise level. There were significant increases in MWT, in CPT, and in the resting and postexercise AP levels in some of these subjects. This was most probably due to increased collateral circulation before, during, and after exercise.
Endoscopic closure of large colonic perforations using an over-the-scope clip: a randomized controlled porcine study
Authors: D. von Renteln, A. Schmidt, M. Vassiliou, H.-U. Rudolph, M. Gieselmann, K. Caca
Journal: Endoscopy (2009)

Background and study aims: Perforation of the colon is considered to be one of the most serious complications of flexible endoscopy. The over-the-scope clip system (OTSC) has previously been shown to close small colonic perforations effectively. The aim of this randomized controlled porcine study was to compare acute closure strengths between the novel 11-mm over-the-scope-clip and surgical closure for large colonic perforations.
Predictors of external cooling failure after cardiac arrest
Authors: Sylvie Ricome, Florence Dumas, Nicolas Mongardon, Olivier Varenne, Jérôme Fichet, Frédéric Pène, Benjamin Zuber, Benoît Vivien, Julien Charpentier, Jean-Daniel Chiche, Jean-Paul Mira, Alain Cariou
Journal: Intensive Care Medicine (2013)
Breast abscess: a rare presentation of typhoid.
Authors: G S Barrett, J MacDermot
Journal: BMJ (1972)

<h3>Abstract</h3> Treatments to stop gray matter degeneration are needed to prevent progressive disability in multiple sclerosis (MS). We tested whether inhibiting mixed-lineage kinases (MLKs), which can drive inflammatory microglial activation and neuronal degeneration, could protect hippocampal synapses in C57BL/6 mice with experimental autoimmune encephalomyelitis, a disease model that recapitulates the excitatory synaptic injury that occurs widely within the gray matter in MS. URMC-099, a broad spectrum MLK inhibitor with additional activity against LRRK2 and other kinases, prevented loss of PSD95-positive postsynaptic structures, shifted activated microglia toward a less inflammatory phenotype, and reversed deficits in hippocampal-dependent contextual fear conditioning in EAE mice when administered after the onset of motor symptoms. A narrow spectrum inhibitor designed to be highly selective for MLK3 failed to protect synapses in EAE hippocampi, and could not rescue cultured neurons from trophic deprivation in an <i>in vitro</i> model of MLK-driven neuronal degeneration. These results suggest that URMC-099 may have potential as a neuroprotective treatment in MS, and demonstrate that a broad spectrum of inhibition against a combination of MLK and other kinases is more effective in neuroinflammatory disease than selectively targeting a single kinase. <b>Significance Statement</b> Multiple sclerosis (MS) causes progressive neurologic decline that correlates with damage to gray matter in the brain, and is not stopped by current treatments. We used a mouse model of MS, in which gray matter injury is associated with inflammatory molecules produced by activated microglia, to test novel neuroprotective treatments. URMC-099, a mixed-lineage kinase (MLK) inhibitor that has anti-inflammatory and direct neuroprotective properties, prevented loss of hippocampal synapses and reversed deficits in learning and memory in a mouse model of MS. An MLK inhibitor with a narrower range of specificity was not effective, suggesting that combination kinase inhibition with URMC-099 may have potential as a neuroprotective treatment in MS.
Is there any benefit in routine wound drainage following mastectomy and axillary clearance?.
Authors: S Shokuhi, K McArdle, S Rai, H Brown, L Vishwanath
Journal: Cancer Research (2009)

Abstract Abstract #4153 Introduction: Seromas are the most frequent complication of breast cancer surgery and are often considered a "necessary evil". Despite limited evidence, suction drains are routinely used to reduce their risk. Drains are an important factor contributing to increased hospital stay as patients are usually reluctant to be discharged before their removal. The aim of this study was to compare the seroma rate post mastectomy and axillary clearance with and without insertion of suction drains.&amp;#x2028; Methods: All patients undergoing mastectomy and axillary clearance treated under the care of three consultant breast surgeons were studied. Data was collected prospectively and analysed retrospectively. Outcome measures included incidence and volume of postoperative seroma, number of aspirations, length of stay and complication rate. Mann-Whitney U test and difference between proportions was used for statistical analysis.&amp;#x2028; Results: Between December 2006 and March 2008 a total of 74 women, median age 63 (range 44-88) underwent 78 mastectomy and axillary clearance (4 bilateral). Patients were divided into three groups. Group 1 no drain, Group 2 one drain, Group 3 two drains.&amp;#x2028; &amp;#x2028; There was no significant difference between the 3 groups in rate of seroma formation. Total volume of seroma and out patient aspirations were significantly higher in group 1 compared with group 3 (P=0.008 and P=0.03 respectively) however there was no significant difference between group 2 and 3. There was no significant difference in complication rates in the three groups. There was a significant reduction in hospital stay in groups 1 and 2 compared to group 3 (P=0.014).&amp;#x2028; Conclusion: Drains did not prevent seroma formation, and were associated with a longer postoperative stay. There was no benefit in insertion of a second drain in reducing seroma volume and number of aspirations required. Second drain leads to a significantly longer hospital stay. The routine use of suction drains post mastectomy may not be warranted. Insertion of two drains is not justified. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 4153.
Allergic Bronchopulmonary Aspergillosis with Adenopathy
Authors: Christina E. Hantsch, Tonny Tanus
Journal: Annals of Internal Medicine (1991)

Brief Report1 October 1991Allergic Bronchopulmonary Aspergillosis with AdenopathyChristina E. Hantsch, BS, Tonny Tanus, MDChristina E. Hantsch, BSSearch for more papers by this author, Tonny Tanus, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-7-546 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAllergic bronchopulmonary aspergillosis, first described by Hinson and associates (1) in 1952, is a hypersensitivity reaction to the fungusAspergillus. In patients with an underlying respiratory disorder such as asthma, the condition progresses to a fibrotic end stage unless it is detected early and treated aggressively with corticosteroids (2). The condition has been recognized more frequently in recent years, and the diagnosis is based on a combination of clinical, immunologic, and radiologic criteria (3). Characteristics of the condition include peripheral blood eosinophilia, immunologic reactivity toAspergillusantigen, increased serum immunoglobulin E levels, central bronchiectasis, and pulmonary infiltrates. No cases of...References1. HinsonMoonPlummer KAN. Bronchopulmonary aspergillosis. Thorax. 1952;7:313-33. Google Scholar2. SafirsteinD'SouzaSimonTaiPepys BMGEJ. Five-year follow-up of allergic bronchopulmonary aspergillosis. Am Rev Respir Dis. 1973;108:450-9. MedlineGoogle Scholar3. RosenbergPattersonMintzerCooperRobertsHarris MRRBMK. Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis. Ann Intern Med. 1977;86:405-14. LinkGoogle Scholar4. GreenbergerPatterson PR. Allergic bronchopulmonary aspergillosis. Model of bronchopulmonary disease with defined serologic, radiologic, pathologic, and clinical findings from asthma to fatal destructive lung disease. Chest. 1987;91(Suppl 6):165S-71S. CrossrefMedlineGoogle Scholar5. MintzerRogersKruglikRosenbergNeimanPatterson RLGMHR. The spectrum of radiologic findings in allergic bronchopulmonary aspergillosis. Radiology. 1978;127:301-7. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: From McGaw Medical Center of Northwestern University, Chicago; and Evanston Hospital, Evanston, Illinois. For current author addresses, see end of text. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHow to Diagnose Allergic Bronchopulmonary AspergillosisLymphadenopathyAspergilosis broncopulmonar alérgica seudotumoralHilar adenopathy in allergic bronchopulmonary aspergillosisRADIOLOGIC ASPECTS OF ALLERGIC BRONCHOPULMONARY ASPERGILLOSISCase 45-1993Hilar Adenopathy in AspergillosisHoward Mann, MD 1 October 1991Volume 115, Issue 7Page: 546-547KeywordsAspergillosisAsthmaBloodBronchiectasisClinical immunologyEosinophiliaHospital medicineHypersensitivityInterleukinsMedical education Issue Published: 1 October 1991 PDF DownloadLoading ...
Weak autoantibody reactions to antigens other than sperm after vasectomy.
Authors: J D Mathews, D C Skegg, M P Vessey, M Konice, E J Holborow, J Guillebaud
Journal: BMJ (1976)

Autoantibody activity against various antigens was measured by indirect immunofluorescence in 97 men about to undergo vasectomy and 170 men who had undergone the operation up to six years earlier. There was a significantly higher prevalence of weakly positive autoantibody reactions among those who had undergone vasectomy. There was, however, no evidence that vasectomy could induce stronger autoantibody reactions such as those associated with autoimmune disease.Serum samples were available from 97 men before vasectomy and from 170 men after the operation. Autoantibody activity was measured by indirect immunofluorescence using compound tissue blocks of rat liver, kidney, and stomach as substrates, Sera were assayed at a dilution of 1:10 using polyspecific fluorescent antibody reagents, At least 1 autoantibody reaction was observed in 127 of the 170 men who had undergone vasectomy (74.7%), compared with 58 of the 97 men with 58 of the 97 men examined before the operation (59.8%) (p less than .02). This difference was considered statistically significant. Men who had had vasectomies tended to each have more autoantibody reactions. However, if weak reactions were disregarded this was not the case. Of the 3 men who had developed wound infections 2 were found to have 3 or more autoantibody reactions. Time after the operation increased the percentage of those having autoantibody reactions (p less than .01). Very strong autoantibody reactions, such as are associated with autoimmune disease, were not found. No undesirable consequences were observed from the presence of the antibodies found after vasectomy.
Leukotriene (LT)‐receptor antagonist is more effective in asthmatic patients with a low baseline ratio of urinary LTE<sub>4</sub> to 2,3‐dinor‐6‐keto‐prostaglandin (PG)F<sub>1α</sub>
Authors: H Tanaka, T Saitoh, K Kurokawa, S Teramoto, N Miyazaki, S Kaneko, M Hashimoto, S Abe
Journal: Allergy (1999)

Background: To test the hypothesis that urinary levels of arachidonic acid metabolites may be a predicting factor of the effects of pranlukast, a selective leukotriene (LT) antagonist, on chronic adult asthma, we investigated the relationship between its clinical efficacy and urinary eicosanoid levels. Methods: An open, multicenter trial was conducted involving 38 stable moderate and severe asthmatic patients (mean percent predicted FEV 1 was 71%). All patients received pranlukast (225 mg twice daily) for 4 weeks after a 2‐week run‐in period. Urinary levels of LTE 4 , 11‐dehydro‐thromboxane (TX) B 2 , 2,3‐ dinor‐6‐keto‐prostaglandin (PG) F 1α , and creatinine were measured in 3‐h urine collected on day 1 of the treatment. The responder was defined by an improvement of asthma symptom scores and peak expiratory flow rate (PEFR). Results: One patient was excluded because of an adverse effect, nausea. Thirteen out of 37 subjects were responders and 24 were nonresponders. There were no significant differences in patients' backgrounds and urinary arachidonate levels between the two groups. The urinary LTE 4 to 2,3‐dinor‐6‐keto‐PGF 1α ratio in the responder was significantly lower ( P =0.01) than that in the nonresponder. In all patients, a significant inverse correlation was revealed between the baseline urinary LTE 4 /2,3‐dinor‐6‐keto‐PGF 1α ratio and the improvement of PEFR in the morning ( r =−0.43, P =0.007). Conclusions: These data suggested that the urinary ratio of LTE 4 to 2,3‐dinor‐6‐keto‐PGF 1α might be one of the predictive markers of the clinical efficacy of this LT‐receptor antagonist in asthmatic subjects.
Uropygial gland of quails, a new and convenient probe for the study of androgen action in sebaceous glands
Authors: J. Y. DANIEL, J. H. ABALAIN, Y. AMET, H. H. FLOCH
Journal: British Journal of Dermatology (1984)

Journal Article Uropygial gland of quails, a new and convenient probe for the study of androgen action in sebaceous glands Get access J. Y. DANIEL, J. Y. DANIEL Laboratoire de Biochimie, ERA 784 du CNRS, Faculte de Medecine, Brest, France Search for other works by this author on: Oxford Academic Google Scholar J. H. ABALAIN, J. H. ABALAIN Laboratoire de Biochimie, ERA 784 du CNRS, Faculte de Medecine, Brest, France Search for other works by this author on: Oxford Academic Google Scholar Y. AMET, Y. AMET Laboratoire de Biochimie, ERA 784 du CNRS, Faculte de Medecine, Brest, France Search for other works by this author on: Oxford Academic Google Scholar H. H. FLOCH H. H. FLOCH Laboratoire de Biochimie, ERA 784 du CNRS, Faculte de Medecine, Brest, France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 111, Issue s27, 1 July 1984, Pages 180–182, https://doi.org/10.1111/j.1365-2133.1984.tb15602.x Published: 01 July 1984
Telling the truth and medical ethics.
Authors: R Gillon
Journal: BMJ (1985)

Gillon discusses the conflicting moral implications of the principles of respect for autonomy and of beneficence and non-maleficence when telling patients the truth about their illnesses and treatments. The case for nondisclosure is usually based on three major arguments: that doctors' Hippocratic obligations to benefit and not harm their patients take precedence over not deceiving them; that the range of possible conditions and prognoses makes it difficult for physicians to know the full truth or for patients to comprehend it; and that patients do not wish to be told dire news. Gillon rejects each of these arguments, contending that avoiding deceit is a basic moral norm that can be defended from utilitarian as well as deontological points of view. With regard to the argument concerning patient attitudes, he recommends that pilot studies be done, asking patients what their preferences are at the time they register with a doctor or hospital.
Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells
Authors: Kai Zhao, Yuxin Zhou, Chen Qiao, Ting Ni, Zhiyu Li, Xiaotang Wang, Qinglong Guo, Na Lu, Libin Wei
Journal: Journal of Hematology & Oncology (2015)

p53 plays important roles in regulating the metabolic reprogramming of cancer, such as aerobic glycolysis. Oroxylin A is a natural active flavonoid with strong anticancer effects both in vitro and in vivo.wt-p53 (MCF-7 and HCT116 cells) cancer cells and p53-null H1299 cancer cells were used. The glucose uptake and lactate production were analyzed using Lactic Acid production Detection kit and the Amplex Red Glucose Assay Kit. Then, the protein levels and RNA levels of p53, mouse double minute 2 (MDM2), and p53-targeted glycolytic enzymes were quantified using Western blotting and quantitative polymerase chain reaction (PCR), respectively. Immunoprecipitation were performed to assess the binding between p53, MDM2, and sirtuin-3 (SIRT3), and the deacetylation of phosphatase and tensin homolog (PTEN). Reporter assays were performed to assess the transcriptional activity of PTEN. In vivo, effects of oroxylin A was investigated in nude mice xenograft tumor-inoculated MCF-7 or HCT116 cells.Here, we analyzed the underlying mechanisms that oroxylin A regulated p53 level and glycolytic metabolism in wt-p53 cancer cells, and found that oroxylin A inhibited glycolysis through upregulating p53 level. Oroxylin A did not directly affect the transcription of wt-p53, but suppressed the MDM2-mediated degradation of p53 via downregulating MDM2 transcription in wt-p53 cancer cells. In further studies, we found that oroxylin A induced a reduction in MDM2 transcription by promoting the lipid phosphatase activity of phosphatase and tensin homolog, which was upregulated via sirtuin3-mediated deacetylation. In vivo, oroxylin A inhibited the tumor growth of nude mice-inoculated MCF-7 or HCT116 cells. The expression of MDM2 protein in tumor tissue was downregulated by oroxylin A as well.These results provide a p53-independent mechanism of MDM2 transcription and reveal the potential of oroxylin A on glycolytic regulation in both wt-p53 and mut-p53 cancer cells. The studies have important implications for the investigation on anticancer effects of oroxylin A, and provide the academic basis for the clinical trial of oroxylin A in cancer patients.
Hemangioma of the Small Intestine With Gastrointestinal Bleeding
Authors: Bong Hak Hyun
Journal: JAMA (1969)

A 12-year-old boy had multiple hemangiomas of the small intestine. Severe chronic hypochromic microcytic anemia (iron deficiency anemia) with occult blood in the feces due to chronic blood loss was a presenting manifestation. Resection of individual hemangiomas at laparotomy resulted in cure of this condition. The possibility of intestinal hemangioma should be considered in the differential diagnosis of gastrointestinal hemorrhage and of intestinal obstruction. Exploratory laparotomy appears to be mandatory for the correct diagnosis and cure of the condition.
EFFECT OF EETINOIC ACID IN PSORIASIS
Authors: LIONEL FRY, ANGUS MACDONALD, R. M. H. McMINN
Journal: British Journal of Dermatology (1970)

Journal Article EFFECT OF EETINOIC ACID IN PSORIASIS Get access LIONEL FRY, LIONEL FRY Department of Dermatology, St Mary's Hospital, London, W.2 (Drs Fry and Macdonald) and Department of Anatomy, King's College, London, W.G.2 (Professor McMinn) Search for other works by this author on: Oxford Academic Google Scholar ANGUS MACDONALD, ANGUS MACDONALD Department of Dermatology, St Mary's Hospital, London, W.2 (Drs Fry and Macdonald) and Department of Anatomy, King's College, London, W.G.2 (Professor McMinn) Search for other works by this author on: Oxford Academic Google Scholar R. M. H. McMINN R. M. H. McMINN Department of Dermatology, St Mary's Hospital, London, W.2 (Drs Fry and Macdonald) and Department of Anatomy, King's College, London, W.G.2 (Professor McMinn) Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 83, Issue 3, 1 September 1970, Pages 391–396, https://doi.org/10.1111/j.1365-2133.1970.tb15723.x Published: 01 September 1970 Article history Accepted: 26 March 1970 Published: 01 September 1970
The relationship between the diameter of chemically-functionalized multi-walled carbon nanotubes and their organ biodistribution profiles in vivo
Authors: Julie T-W. Wang, Chiara Fabbro, Enrica Venturelli, Cécilia Ménard-Moyon, Olivier Chaloin, Tatiana Da Ros, Laura Methven, Antonio Nunes, Jane K. Sosabowski, Stephen J. Mather, Martyn K. Robinson, Julien Amadou, Maurizio Prato, Alberto Bianco, Kostas Kostarelos, Khuloud T. Al-Jamal
Journal: Biomaterials (2014)