tbuckley/cabot-search huggingface dataset:
Muscular hyperplasia ("cirrhosis") of the lung and bronchial dilatations as features of chronic diffuse fibrosing alveolitis.
Authors: D Davies, A MacFarlane, C S Darke, O G Dodge
Journal: Thorax (1966)

Muscular 'cirrhosis' of the lung was first described by von Buhl in 1872.An occasional case was described afterwards, but the number has increased in recent years.We have found 25 cases published between 1940 and 1964 that have conformed reasonably well to the accepted concept of the condition.Sixteen of these have come from the United States of America, four from Mexico, two from France, and one each from Scandinavia, Canada, and Britain.These cases are summarized in Table I, together with the five cases now reported.They have been published under various titles, the commonest being muscular cirrhosis of the lung, pulmonary muscular hyperplasia, and bronchiolar emphysema.Some cases published under these titles have not been included because Intrapulmonary Cysts 0_ 0 -20 mm.pea 1-5 mm.1-2 mm.1-3 mm.small 1-5 mm.< 5 mm.small 4 mm.0 + 1-4mm._ + --3-30 mm.+ + 3-5mm.-1-5 mm.0 + + 5-20 mm.+ <30mm.+ <10mm.+ <15mm.<15 mm.+ 5mm.
The Social Context of Medical Research
Authors: Robert J. Levine
Journal: JAMA (1982)

The purpose of this book, according to its editors, "is to discuss medical research in its social context and to explore the many issues and problems that arise with regard to both the conduct of research and the application of research findings." It seems to me that this anthology accomplishes these objectives well. The contributors to this book represent such diverse fields as medicine, ethics, public health, sociology, and administration. In contrast with most anthologies, this one shows clear evidence that the contributors were given careful instructions regarding their own and each other's assignments. Consequently, there is remarkably little duplication. The first five chapters are concerned with problems that arise in the planning and performance of research. First there is an overview of the types of value conflicts presented by research and the ways in which various public agencies act to attempt their resolution. This is exemplified in a detailed
TCT-582 Eighteen Month Clinical and Imaging Results from the DESSOLVE I First-in-Human Trial of the MiStent® SES with Absorbable Polymer
Authors: John Ormiston, James Stewart, Mark Webster, Mathias Vrolix, Robert Whitbourn, Dennis Donohoe, Charlene Knape, Alexandra Lansky, Hiram Bezerra, Peter Fitzgerald, David Kandzari, William Wijns
Journal: Journal of the American College of Cardiology (2012)
Effect of Cardiac Resynchronization on Myocardial Efficiency and Regional Oxidative Metabolism
Authors: Heikki Ukkonen, Rob S.B. Beanlands, Ian G. Burwash, Robert A. de Kemp, Claude Nahmias, Ernest Fallen, Michael R.S. Hill, Anthony S.L. Tang
Journal: Circulation (2003)

Background— Recent studies have demonstrated increased left ventricular contractility with cardiac resynchronization therapy (CRT) using atriobiventricular stimulation. This study evaluated the effect of CRT on myocardial oxidative metabolism and efficiency. Methods and Results— Eight patients with New York Heart Association functional class III-IV congestive heart failure were studied during atrial pacing (control) and atriobiventricular stimulation at the same rate. The monoexponential clearance rate of [ 11 C]acetate (k mono ) was measured with positron emission tomography to assess myocardial oxidative metabolism in the left and right ventricles (LV and RV, respectively). Myocardial efficiency was measured using the work metabolic index (WMI). Stroke volume index improved by 10% ( P =0.011) with CRT, although both global LV and RV k mono were unchanged compared with control. Septal k mono increased by 15% ( P =0.04), and the septal/lateral wall k mono ratio increased by 22% ( P =0.01). WMI increased by 13% ( P =0.024) with CRT. Conclusions— CRT improves LV function without increasing global LV oxidative metabolism, resulting in improved myocardial efficiency. Oxidative metabolism of the interventricular septum increases relative to the lateral wall, which suggests successful resynchronization.
RELAPSE PHENOMENA OF SPIRONEMA RECURRENTIS
Authors: Henry Edmund Meleney
Journal: The Journal of Experimental Medicine (1928)

1. Squirrels and chipmunks were found to be susceptible to infection with the Spironema recurrentis of North China, but no relapses occurred in normal animals. 2. Splenectomy caused an increase in the intensity of the infection and the appearance of one or two relapses. 3. By inoculating splenectomized squirrels with a single human strain of spirochetes, six different strains were produced as a result of relapses. 4. The strains all retained their specific agglutinating characteristics during the period of observation. The oldest strain was observed for 132 days and through 38 transfers, the strain last isolated for 22 days and through 6 transfers. 5. The sequence of strains in relapses was not always the same. Sometimes new strains were produced, at other times there was reversion to an older strain. 6. Certain relationships between strains were established. The related strains were always those which appeared, or theoretically might have appeared, in alternate attacks. In only one case did related strains appear in two consecutive attacks. 7. Squirrels whose spleens were not removed had only one attack and developed immune substances only against the strain inoculated or against closely related strains. It was possible by reinoculation to produce infection in such squirrels with as many as four different strains in succession. 8. The spleen has a protective influence against the development of the relapse in the squirrel, but apparently does not control the formation of specific immune substances. 9. An explanation of the clinical course of relapsing fever is suggested on the basis of the observations recorded. 10. There is, at present, no justification for the division of the spirochetes of relapsing fever into different species.
Relationship of curve running to the angle of lanes of a standard running track: an introspection to the innovation
Authors: Kamalakanti R Debnath, Alka I Karanwal
Journal: British Journal of Sports Medicine (2010)

The often heard cliché, ‘It sounds good in theory but won't work in practice,’ is not as non-sensical as it is assumed. This idea reflects critical limitations of theories in general and learning theories in particular. Since a basic assumption of this paper is that theoretical concepts of track and field techniques are essential tools of out profession, some attempt must be made to clarify these limitations and to show how the ‘theory versus practice’ dichotomy can be brought closer and together. The problem central to the study of the 200 m is best phrased in this question: ‘What major variables should be evaluated in training for and training and running the 200 meters?’. Answering this question, one must consider the following variables: lane assignment, angle of lane and developing a pace chart which are fit into independent, dependent, control variables. A look at lane-1 versus lane-8 reveals that the geometric design of the standard track suggests the lane-8 has the least severe angle (145.79°) as compare with lane-1 (180°). The physics of the relationship between a moving body in lane-8 as compared with lane-1 suggests that the inertia generated in lane-1 is greater than that of lane-8. Theoretically, this concept suggests that if a runner in lane-8 exerts the same energy as a runner in lane-1, the runner in lane-8 should be ahead based on the theoretical energy created in the outer perimeter of the circle.
Liverpool University suspends professor for alleged research misconduct
Authors: C. Dyer
Journal: BMJ (2011)

A 5 year old girl with gross gastrooesophageal reflux had pronounced dystonic neck movements that resolved after fundoplication and resolution of the oesophagitis (Sandifer9s syndrome). Oesophageal manometry before operation showed that peristalsis improved when she tilted her head to one side. Dystonic posturing may promote acid clearance from the distal oesophagus.
Allergen‐specific immunotherapy. Present state and directions for the future
Authors: H.‐J. Mailing
Journal: Allergy (1999)

To cite this article: Mailing H.‐J . Allergen‐specific immunotherapy. Present state and directions for the future. Allergy 1999, 54, 30–33. Copyright © Munksgaard 1999 ISSN 0108–1675
IL-10 Inhibits Inflammation and Attenuates Left Ventricular Remodeling After Myocardial Infarction via Activation of STAT3 and Suppression of HuR
Authors: Prasanna Krishnamurthy, Johnson Rajasingh, Erin Lambers, Gangjian Qin, Douglas W. Losordo, Raj Kishore
Journal: Circulation Research (2008)

Persistent inflammatory response has adverse effects on left ventricular (LV) function and remodeling following acute myocardial infarction. We hypothesized that suppression of inflammation with interleukin (IL)-10 treatment attenuates LV dysfunction and remodeling after acute myocardial infarction. After the induction of acute myocardial infarction, mice were treated with either saline or recombinant IL-10, and inflammatory response and LV functional and structural remodeling changes were evaluated. IL-10 significantly suppressed infiltration of inflammatory cells and expression of proinflammatory cytokines in the myocardium. These changes were associated with IL-10-mediated inhibition of p38 mitogen-activated protein kinase activation and repression of the cytokine mRNA-stabilizing protein HuR. IL-10 treatment significantly improved LV functions, reduced infarct size, and attenuated infarct wall thinning. Myocardial infarction-induced increase in matrix metalloproteinase (MMP)-9 expression and activity was associated with increased fibrosis, whereas IL-10 treatment reduced both MMP-9 activity and fibrosis. Small interfering RNA knockdown of HuR mimicked IL-10-mediated reduction in MMP-9 expression and activity in NIH3T3 cells. Moreover, IL-10 treatment significantly increased capillary density in the infarcted myocardium which was associated with enhanced STAT3 phosphorylation. Taken together, our studies demonstrate that IL-10 suppresses inflammatory response and contributes to improved LV function and remodeling by inhibiting fibrosis via suppression of HuR/MMP-9 and by enhancing capillary density through activation of STAT3.
Effects of Digoxin-Specific Antibodies on Accumulation and Binding of Digoxin by Human Erythrocytes
Authors: Jerry D. Gardner, Diane R. Kiino, Timothy J. Swartz, Vincent P. Butler
Journal: Journal of Clinical Investigation (1973)

THE PRESENT STUDIES INDICATE THAT ACCUMULATION OF DIGOXIN BY INTACT HUMAN ERYTHROCYTES IS THE RESULT OF TWO PROCESSES: binding of digoxin to the erythrocyte membrane and uptake of digoxin across the membrane into the cell. In contrast, accumulation of ouabain by human erythrocytes is entirely attributable to binding of this glycoside to the plasma membrane. Digoxin binding to the erythrocyte membrane involves a single class of binding sites, is a saturable function of the extracellular digoxin concentration, reversible, temperature-sensitive, dependent on the cation composition of the incubation medium, inhibited by other cardioactive steroids, and correlates with the inhibition of erythrocyte potassium influx. Digoxin uptake across the membrane into the cell is also temperature-sensitive and reversible but is a linear function of the extracellular digoxin concentration, not altered by changes in the cation composition of the incubation medium, not inhibited by other cardioactive steroids, and does not correlate with inhibition of erythrocyte potassium influx. Digoxinspecific antibodies can both prevent and reverse effects of digoxin on potassium influx in human erythrocytes by virtue of the capacity of the antibodies to decrease the amount of digoxin that is bound to the erythrocyte membrane. These antibodies also reduce uptake of digoxin across the plasma membrane into the erythrocyte; however, this portion of cellular digoxin is not responsible for the observed inhibition of potassium influx. In the presence of digoxin-specific antibodies, the changes in digoxin binding to the erythrocyte membrane and in digoxin uptake across the membrane into the cell reflect the ability of the antibodies to form complexes with "free" digoxin molecules in the incubation medium and thereby decrease the effective concentration of digoxin.
Pancreatic Polypeptide: A Marker for Lean Non-insulin-dependent Diabetes Mellitus?
Authors: F John Service, Mark B Koch, Joan M Jay, Robert A Rizza, Vay L W Go
Journal: Diabetes Care (1985)

Both basal and postprandial pancreatic polypeptide (PP) concentrations were exaggerated twofold in lean NIDDM patients, whereas they were normal in lean IDDM and obese NIDDM patients who were hyperglycemic as a result of partial insulin withdrawal. Insulin infusion from an artificial endocrine pancreas, which resulted in fasting euglycemia and near-normoglycemia postprandially, had no effect on PP responses in any of the diabetic patients. No postprandial PP responses were observed in totally pancreatectomized (TPX) patients. Excessive basal and postprandial concentrations of PP in diabetes appear to be related to both leanness and residual beta cell function and, therefore, potential markers for lean NIDDM.
Risk factor clustering in the insulin resistance syndrome and its relationship to cardiovascular disease in postmenopausal white, black, hispanic, and Asian/Pacific Islander women
Authors: Barbara V. Howard, Michael H. Criqui, J.David Curb, Rebecca Rodabough, Monika M. Safford, Nanette Santoro, Alan C. Wilson, Judith Wylie-Rosett
Journal: Metabolism (2003)
Launching Complex Medical Workups From an Urgent Care Platform
Authors: Dean Paschal
Journal: Annals of Internal Medicine (2012)

The basic parameters for medical workups have scarcely changed in the past 30 years. That is, what the internal medicine community has deemed acceptable for outpatient, inpatient, emergency department, and urgent care evaluation has remained pretty much stable or stagnant during all that time. We are failing to take advantage of the phenomenal speed and accuracy of new laboratory and imaging technologies. Due to Hurricane Katrina, which destroyed the Veterans Administration Hospital in New Orleans, those of us who work in its urgent care clinic were forced to undertake complex medical workups from an 8-to-5, walk-in platform. We have been amazed at the efficiency of this. Workups that used to take weeks can often be done in a few hours or days. What we have discovered here serendipitously may be worth deliberately duplicating elsewhere.
Needs are never demands
Authors: D. Wheldon
Journal: BMJ (1995)

EDITOR,—In the first paragraph of their article in the series on management for doctors John Stuart and colleagues refer to “the multiple demands of an increasingly aging population.”1 From this single line one may guess the nature of the article. The phrase is pejorative and redolent of those ideas taken for granted in a selfish political age. The word “demands” is used when the less loaded word “needs” is more …
The Biochemical Basis of Neuropharmacology.
Authors: Jack R. Cooper, Floyd E. Bloom, Robert H. Roth
Journal: Annals of Internal Medicine (1974)

Over the past 15 years, this volume has become widely recognized as the best on its subject, providing the liveliest and most lucid available account of neurotransmitters and their relation to drug action. The fifth edition features two new chapters on topics of current interest: molecular neurobiology and neuromodulation. In addition, all other chapters have been updated. It is a useful book for a wide variety of students and professionals, including neuroscientists, clinical neurologists, psychiatrists, psychologists, biochemists and pharmacologists.
Peripheral Neuritis in Systemic Lupus Erythematosus
Authors: R. H. Heptinstall, G. S. C. Sowry
Journal: BMJ (1952)

ASPERGILLOSISBRDI,TISH 525 man (1950) of three cases of mycotic endocarditis, two of which were due to aspergillus infection, following antibiotic therapy.We would suggest that in this case, also, the use of penicillin and chloramphenicol predisposed the damaged lung to infection with Aspergillus fumigatus, and that the terminal condition was due to the fungus rather than to any pathogenic bacteria.The case has been presented, therefore, to illustrate one of the dangers of antibiotic therapy-a subject of considerable interest at the present time.With the increasing use of antibiotics, similar cases may be seen more often in the future. SummaryA middle-aged woman was treated with penicillin, streptomycin, and chloramphenicol for post-influenzal bronchopneumonia.At post-mortem examination the presence of Aspergillus futmigatus infection of the lungs was discovered.The relation of the infection to anti- biotic therapy is discussed.
Cutaneous reactions following herpes zoster infections: report of three cases and a review of the literature
Authors: M. DAVIS GIBNEY, G. T. NAHASS, C. L. LEONARDI
Journal: British Journal of Dermatology (1996)

Three patients, one healthy and two immunocompromised, developed cutaneous reactions that histologically mimicked granuloma annulare at sites of resolved varicella-zoster virus (VZV) reactivation infections. Variable latency periods between the infection and the granulomatous reaction were noted. As in other case reports, the presence of VZV DNA in these lesions was inconsistently demonstrated by the polymerase chain reaction (PCR) and appears more common in early, as opposed to late, post-zoster granulomas. In addition to various granulomatous reactions, vasculitic and neoplastic eruptions following resolved VZV infections have been described and are reviewed here. Therapeutically, topical, intralesional and systemic corticosteroids, as well as acyclovir, have been tried with inconsistent results. Although the pathogenesis remains unclear, the presence of VZV DNA in early lesions that histologically do not display viral cytopathic changes, suggests the virus induces an atypical delayed hypersensitivity reaction not affected by antiviral therapy.
Reactivity to Pressor Agents in Hypertension
Authors: AUSTIN E. DOYLE, HAROLD BLACK
Journal: Circulation (1955)

The pressor responses to intravenous injections of angiotonin and s-methyl iso -thiourea have been studied in 50 hypertensive subjects and 20 normotensive controls. The rises of blood pressure in the two groups were similar, being but slightly greater in the hypertensives. After the blood pressure has been reduced with hexamethonium, however, the pressor responses to angiotonin, s-methyl isothiourea and noradrenaline are much greater in hypertensives than normotensive subjects. The responses under these conditions to all three pressor agents run parallel to each other, suggesting that there is no specific increase in reactivity in hypertensive subjects, either to angiotonin or noradrenaline. It has been concluded that there is evidence of increased reactivity to pressor substances in hypertensive subjects but that this is not demonstrable until the blood pressure control mechanisms have been inactivated by hexamethonium.
A SERIES OF INTERESTING GYNECOLOGIC AND OBSTETRIC CASES.I.—AN EIGHTY-NINE POUND CYSTIC MYOMA. II.—A LARGE PARASITIC MYOMA. III.—MULTIPLE PERFORATION OF THE UTERUS DUE TO A MACERATED FETUS. IV.—ABDOMINAL PREGNANCY OF FOUR YEARS' DURATION. V.—CHORIOEPITHELIOMA.
Authors: THOMAS S. CULLEN
Journal: JAMA (1907)

<h3>SUCCESSFUL REMOVAL OF AN EIGHTY-NINE-POUND CYSTIC MYOMA INTACT.</h3> As will be noted from the following history, this patient was cognizant of the fact that the tumor had existed for over 20 years. At that time she was under the care of Dr. James Bosley, the present health officer of Baltimore. Further, it will be seen that this large growth did not prevent her from looking after her household duties until recently, and less than three months before the operation she took a 180-mile trip with no ill effects. This, so far as we can learn, is the largest myoma of the uterus that has been successfully removed. The patient is now, eight months after the operation, in perfect health and is gaining rapidly in weight. <h3>Case 1.</h3> —Mrs. McA., aged 58, was seen in consultation with Dr. Marshall Smith, June 25, 1906. <h3>History.</h3> —Twenty years ago she noticed a tumor
Modifications of Adenovirus Hexon Allow for Either Hepatocyte Detargeting or Targeting With Potential Evasion From Kupffer Cells
Authors: Jan-Michael Prill, Sigrid Espenlaub, Ulrike Samen, Tatjana Engler, Erika Schmidt, Francesco Vetrini, Amanda Rosewell, Nathan Grove, Donna Palmer, Philip Ng, Stefan Kochanek, Florian Kreppel
Journal: Molecular Therapy (2010)

In vivo gene transfer with adenovirus vectors would significantly benefit from a tight control of the adenovirus-inherent liver tropism. For efficient hepatocyte transduction, adenovirus vectors need to evade from Kupffer cell scavenging while delivery to peripheral tissues or tumors could be improved if both scavenging by Kupffer cells and uptake by hepatocytes were blocked. Here, we provide evidence that a single point mutation in the hexon capsomere designed to enable defined chemical capsid modifications may permit both detargeting from and targeting to hepatocytes with evasion from Kupffer cell scavenging. Vector particles modified with small polyethylene glycol (PEG) moieties specifically on hexon exhibited decreased transduction of hepatocytes by shielding from blood coagulation factor binding. Vector particles modified with transferrin or, surprisingly, 5,000 Da PEG or dextran increased hepatocyte transduction up to 18-fold independent of the presence of Kupffer cells. We further show that our strategy can be used to target high-capacity adenovirus vectors to hepatocytes emphasizing the potential for therapeutic liver-directed gene transfer. Our approach may lead to a detailed understanding of the interactions between adenovirus vectors and Kupffer cells, one of the most important barriers for adenovirus-mediated gene delivery.
p75NTR Differentially Regulates TLR4/TLR9 Expression in Vernal Keratoconjunctivitis Derived Primary Cultures of Epithelial Cell and Fibroblasts exposed to NGF
Authors: A. Micera, B. Stampachiacchiere, E. Normando, A. Lambiase, S. Bonini, S. Bonini
Journal: Journal of Allergy and Clinical Immunology (2010)