tbuckley/cabot-search huggingface dataset:
A one season prospective cohort study of volleyball injuries
Authors: E A L M Verhagen, A J Van der Beek, L M Bouter, R M Bahr, W Van Mechelen
Journal: British Journal of Sports Medicine (2004)

Objective: To estimate the overall incidence of acute and overuse volleyball injuries, and to describe factors associated with ankle sprains. Methods: 486 players from the second and third Dutch national volleyball divisions participated in the study and were followed prospectively during a whole season. Three measurements were made during the season (baseline, follow up 1, and follow up 2), where all players completed a questionnaire on demographic variables (only at baseline), sports participation, use of preventive measures, and previous injuries. Volleyball exposure during training and matches was recorded for each individual player by the coach on a weekly exposure form. In case of injury the coach provided the injured player with an injury registration form, which had to be completed within one week after the onset of injury. Results: 100 injuries were reported, resulting in an overall injury incidence of 2.6 injuries/1000 hours. The incidence of acute injuries was 2.0/1000 hours. Ankle sprains (n = 41) accounted for most of the acute injuries, and 31 (75%) of all players with an ankle sprain reported a previous ankle sprain. Twenty five overuse injuries were reported. The overall incidence of overuse injuries was 0.6/1000 hours; the back and the shoulder were the most common sites. Conclusions: Ankle sprain is the most common injury in volleyball, accounting for 41% of all volleyball related injuries. Previous injury seems to be an important risk factor for an ankle sprain. Injury prevention programmes should focus on ankle sprains and concentrate on players with previous ankle sprains.
Addison's Disease and Pregnancy
Authors: T. A. Richards
Journal: BMJ (1952)

it was almost invariably fatal (Perkins, 1932).More recently cases successfully managed through pregnancy have been described (Thom et al., 1941described (Thom et al., , 1942;;Sheldon, 1945;Zwanenberg, 1945;Simpson, 1946;Knowlton et al., 1949).Crises may occur in the early stages due to vomiting, but, once these have passed, the patients usually remain well until after delivery.In the first few days of the puerperium, however, crises of acute adrenal insufficiency are frequent.Hypoglycaemia may also be a serious complication, and irreversible coma may occur.Knowl- ton et al. (1949) recommend stabilization throughout the pregnancy with daily injections of intramuscular doca to allow for requirements which vary in the different stages.Little extra salt is advised,.togive a wider margin of safety should vomiting occur and salt ingestion be discontinued.After delivery, intravenous glucose saline, I to 2 litres, and additional eucortone, 20 to 40 ml., are given daily.
New centre seeks to promote global health security
Authors: T. Richards
Journal: BMJ (2009)

A new think tank, funded by England’s Department of Health, has been launched to identify and offer solutions to maintain global health security.

The Chatham House Centre on Global Health Security will analyse the factors underpinning the health security of individuals and the vulnerability of populations to global health threats. Where problems and weaknesses in mechanisms and policies are identified, it will recommend ways in which the public health and international affairs communities can overcome them. It will then monitor the effects of the interventions. …
<i>RET</i> Fusion Genes in Non–Small-Cell Lung Cancer
Authors: Bo H. Chao, Roger Briesewitz, Miguel A. Villalona-Calero
Journal: Journal of Clinical Oncology (2012)

Article Tools UNDERSTANDING THE PATHWAY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2012.45.8240 Journal of Clinical Oncology - published online before print November 13, 2012 PMID: 23150705 RET Fusion Genes in Non–Small-Cell Lung Cancer Bo H. ChaoxBo H. ChaoSearch for articles by this author , Roger BriesewitzxRoger BriesewitzSearch for articles by this author , Miguel A. Villalona-CaleroxMiguel A. Villalona-CaleroSearch for articles by this author Show More The Ohio State University; and the Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OHArthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OHThe Ohio State University; and the Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH https://doi.org/10.1200/JCO.2012.45.8240 First Page Full Text PDF Figures and Tables © 2012 by American Society of Clinical Oncology
[310] CELL CYCLE QUIESCENCE IS ASSOCIATED WITH THE HEPATOBILIARY GENE EXPRESSION IN HUMAN INTRAHEPATIC BILIARY EPITHELIAL CELL LINES IN VITRO
Authors: A. Komori, S. Fujiwara, Y. Aiba, M. Nakamura, S. Shimoda, H. Fujioka, K. Migita, M. Ito, K. Yano, H. Yatsuhashi, H. Ishibashi
Journal: Journal of Hepatology (2007)
Fetal Alcohol Syndrome in Adolescents and Adults
Authors: Ann Pytkowicz Streissguth
Journal: JAMA (1991)

Fetal alcohol syndrome is a specific recognizable pattern of malformation. Manifestations in 61 adolescents and adults suffering from alcohol teratogenesis are presented. After puberty, the faces of patients with fetal alcohol syndrome or fetal alcohol effects were not as distinctive. Patients tended to remain short and microcephalic, although their weight was somewhat closer to the mean. The average IQ was 68, but the range of IQ scores widely varied. Average academic functioning was at the second- to fourth-grade levels, with arithmetic deficits most characteristic. Maladaptive behaviors such as poor judgment, distractibility, and difficulty perceiving social cues were common. Family environments were remarkably unstable. Fetal alcohol syndrome is not just a childhood disorder; there is a predictable long-term progression of the disorder into adulthood, in which maladaptive behaviors present the greatest challenge to management.
Transplacental Transmission of Natural-Killer-Cell Lymphoma
Authors: Edgardo D. Carosella, Jean Dausset, Nathalie Rouas-Freiss
Journal: New England Journal of Medicine (1999)

Coronary Artery Disease in Men and WomenTo the Editor: Vaccarino et al. (July 22 issue) 1 show that younger women, but not older women, have higher rates of death during hospitalization after acute myocardial infarction than men of the same age.Potential reasons for their findings include differences between men and women with respect to the aggressiveness of the disease, the treatment strategies used, and rates of death before hospitalization.Studies from the World Health Organization's Monitoring Trends and Determinants in Cardiovascular Disease (MONICA) project have shown that a higher rate of death from acute myocardial infarction during hospitalization among women may be balanced by a higher rate of National Board of Health and Welfare S-106 30 Stockholm, Sweden N IKLAS H AMMAR , P H .
P577 BENEFICIAL EFFECT OF MULTIDISCIPLINARY APPROACH ON SURVIVAL IN HEPATOCELLULAR CARCINOMA PATIENTS
Authors: H.T. Kani, A. Siykhymbayev, N. Demircan, M. Banzragch, E. Gunes Yegin, E. Bicakci, Y. Aydin, R. Irmak, D. Guney Duman, P.F. Yumuk, F. Dane, N.S. Turhal, N. Bekiroglu, O.C. Ozdogan
Journal: Journal of Hepatology (2014)
THE RADICAL OPERATION IN UTERINE CANCER.
Authors: ALFONS VON ROSTHORN
Journal: JAMA (1906)

When you did me the honor of inviting me to speak to you here it was no easy task for me to choose a subject which might prove of sufficient interest. The fact of my being invited to speak in a country in which some of the most fundamental facts of modern gynecology have been established, a country which by its tireless seeking for knowledge and by its many important discoveries in our particular branch has carved for itself such a gloriously high place in the scroll of nations, certainly increases the difficulty of my choice of a theme about which to address you. It seems to me that the best way in which I can respond to your kind invitation is to give you a short résumé of the progress in a subject which in Germany has been followed with intense zeal, and whose importance is acknowledged to be
Specification on the Definition of Adult-Type Soft Tissue Sarcoma
Authors: Andrea Ferrari, Michela Casanova
Journal: Journal of Clinical Oncology (2006)

biased by a definition which is not necessarily adherent to that now clearly stated in the consensus WHO-European Organisation for Research and Treatment of Cancer classification (ie, diffuse infiltration by round, noncleaved cells, heavily expressing bcl-2 and MUM-1, and genetically characterized by an activated B-cell profile.)In our study, although a centralized histologic revision was not performed, the pathologists from each participating center were asked to review their cases strictly following the criteria which currently allow to them to separate diffuse large B-cell lymphoma, leg-type from follicular lymphoma patients with a diffuse large (cleaved) cell predominance.This method appears as substantially different from that followed by Smith et al 4 in their study.However, there is no doubt that this latter has added an interesting piece of work to the diagnosis, classification, prognostic evaluation, and proper treatment planning of primary CBCL.
AB0910 Validity and reliability of the IPAQ and squash to assess daily physical activity in patients with ankylosing spondylitis
Authors: S. Arends, M. Hofman, Y.P.T. Kamsma, E. van der Veer, M.K. Leijsma, P.M. Houtman, C.G.M. Kallenberg, A. Spoorenberg, E. Brouwer
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Physical activity questionnaires are considered to be the most applicable method to assess daily physical activity in population studies because of participant convenience, minimal cost, and scoring flexibility. The International Physical Activity Questionnaire (IPAQ) and the Short QUestionnaire to Asses Health-enhancing physical activity (SQUASH) are recall questionnaires that have acceptable construct validity and moderate to high test-retest reliability in healthy populations.(1,2) Until now, the validity and reliability of these physical activity questionnaires have not been studied in patients with ankylosing spondylitis (AS). <h3>Objectives</h3> To investigate the construct validity and test-retest reliability of the IPAQ and SQUASH in patients with AS. <h3>Methods</h3> The self-report questionnaires IPAQ (long form) and SQUASH were compared with daily physical activity assessed using the ActiGraph accelerometer during 7 consecutive days (gold standard) in 63 AS outpatients. The IPAQ and SQUASH were administered on two different occasions approximately one week apart in 52 AS outpatients. All patients fulfilled the modified New York criteria for AS or the ASAS criteria for axial spondyloarthritis. Validity was examined by calculating Spearman's and Pearson's correlation coefficients between accelerometer activity counts and IPAQ and SQUASH total scores, respectively. Test-retest reliability of the IPAQ and SQUASH was investigated by calculating intraclass correlation coefficients (ICC) between the first and the second assessments of the questionnaires. Additionally, Bland-Altman analysis was performed. <h3>Results</h3> Mean age of the in total 115 AS patients was 45 years (SD ± 12), median disease duration was 16 years (range 0-54), and 62% were male. IPAQ and SQUASH total scores correlated significantly with accelerometer outcome: ρ=0.38 and r=0.35, respectively. ICC's between first and second assessments of the IPAQ and SQUASH were 0.83 and 0.89, respectively. Bland-Altman analyses showed no systemic bias, but in particular for the IPAQ the 95% limits of agreement were wide. <h3>Conclusions</h3> Both physical activity questionnaires showed moderate construct validity. The SQUASH showed good test-retest reliability, superior to the IPAQ. These results indicate that the SQUASH can be used to assess daily physical activity in AS population studies. <h3>References</h3> Craig CL, Marshall AL, Sjostrom M, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35:1381-95. Wendel-Vos GC, Schuit AJ, Saris WH, et al. Reproducibility and relative validity of the short questionnaire to assess health-enhancing physical activity. J Clin Epidemiol. 2003;56:1163-9. <h3>Disclosure of Interest</h3> None Declared
Decreased in vitro humoral immune responses in aged humans.
Authors: S G Pahwa, R N Pahwa, R A Good
Journal: Journal of Clinical Investigation (1981)

Induction of antigen-specific and non-specific (polyclonal) humoral immune responses in vitro was investigated in peripheral blood mononuclear cells of aged (65-85 yr) and young (20-30 yr) volunteers. In vitro immunization of lymphocytes with antigen (sheep erythrocytes) was performed in a recently described microculture system, and anti-sheep erythrocyte plaque forming cells were quantitated in a direct hemolytic plaque assay. Immunoglobulin secreting cells, induced polyclonally with pokeweed mitogen, were quantitated in a reverse hemolytic plaque assay. Significant depressions of antigen-specific as well as polyclonal responses were noted in relation to advancing age. Antigen-specific responses were more frequently depressed than polyclonal responses. T cell mitogen concanavalin A (Con A) was used to amplify functions of autologous immunoregulatory T cells. Addition of 10 microgram/ml Con A to lymphocytes of young donors at culture initiation resulted in activation of suppressor cells and abrogated antigen-specific responses. Delayed addition of Con A, on the other hand, enhanced responses, presumably because of activation of helper T cells. Similar manipulations of lymphocyte cultures from aged donors showed failure of Con A to suppress antigen-specific responses in approximately half of the responders. In many nonresponders, responses within normal range were elicited by the delayed addition of Con A to their lymphocyte cultures. Deviations beyond the range of expected responses were noted in 32.5% of the co-cultures between pokeweed mitogen stimulated young and aged cells. Our findings suggest that age-related deficiencies of B cell function are frequently associated with dysfunction of immunoregulatory T cells and are only occasionally due to intrinsic defects of B cells.
Refeeding David Blaine — Studies after a 44-Day Fast
Authors: Márta Korbonits, David Blaine, Marinos Elia, Jeremy Powell-Tuck
Journal: New England Journal of Medicine (2005)

The opportunity to study the effects of refeeding after prolonged fasting is rare. We recorded anthropometric, biochemical, and endocrine changes during the refeeding period after a much-publicized 44-day fast by David Blaine, a performance artist; we compared the findings with results obtained from a control group of 16 age-matched men who had a similar body-mass index (the weight in kilograms divided by the square of the height in meters) after an overnight fast.
RHODE ISLAND MEDICAL SOCIETYAnnual Meeting, held May 31, 1910
Authors: Eugene Kingman
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effective Absorption and Utilization of Oral Formyltetrahydrofolate in Man
Authors: Peter F. Nixon, Joseph R. Bertino
Journal: New England Journal of Medicine (1972)

Reversal of the effects of antifolates requires effective expansion of the body pool of reduced folate coenzymes. In the past, this has required parenteral use of 5-formyltetrahydrofolate. By use of Radio-labeled 5-formyltetrahydrofolate, we showed that its oral administration also expands the body reduced folate pool. After oral administration of 5-formyl-14C-tetrahydrofolate-3H to fasting subjects, the labels appeared in the serum, peaking at 60 minutes. Chromatographic analysis showed that the labeled serum folate was principally the naturally occurring 5-methyltetrahydrofolate-3H. Close to 90 per cent of orally administered 5-formyltetrahydrofolate appeared to be absorbed. The most constant labeled urinary folate was found to be 10-formyltetrahydrofolate or 5, 10-methenyltetrahydrofolate. Renal excretion of labeled 5-formyltetrahydrofolate occurred at undetectable serum levels whereas renal excretion of labeled 5-methyltetrahydrofolate was proportional to its serum concentration.
Recombinant human granulocyte‐macrophage colony‐stimulating factor plus recombinant human erythropoietin may improve anemia in selected patients with myelodysplastic syndromes
Authors: Per Boye Hansen, Hans E. Johnsen, Erik Hippe, Eva Hellström‐Lindberg, Elisabeth Ralfkiaer
Journal: American Journal of Hematology (1993)

Abstract The purpose of this study was to improve erythropoiesis in patients with anemia due to myelodysplastic syndromes (MDS). We treated 13 patients first with recombinant human granulocyte‐macrophage colony‐stimulating factor (rhGM‐CSF) for 6 weeks, then with recombinant human erythropoietin (rhEpo) and rhGM‐CSF for the next 12 weeks. Five patients had refractory anemia (RA), 3 refractory anemia with ringed sideroblasts (RAS), and 5 refractory anemia with excess of blasts (RAEB). Ten patients were transfusion‐dependent at the time of inclusion. Eleven patients completed this phase II study. Five responded with an increase in hemoglobin level (3 patients) or a reduction in transfusion requirement (2 patients). We registered no response in the remaining 6 patients during treatment. Patients responding to combined treatment had relatively low concentrations of plasma Epo and plasma ferritin before treatment with rhEpo and a normal karyotype throughout the study. Long‐term bone marrow cultures did not predict the response. Still, responders seemed to have a higher number of colony‐forming progenitors than non‐responders. In conclusion, combined therapy with rhGM‐CSF and rhEpo may stimulate hematopoiesis and correct or improve anemia in some patients with MDS. © 1993 Wiley‐Liss, Inc.
Severe cutaneous reactions to captopril.
Authors: M J Goodfield, L G Millard
Journal: BMJ (1985)

llll action of phosphine in man is not known.It has, however, been found to cause non-competitive inhibition of cytochrome oxidase of mito- chondria in mouse liver, housefly, and granary weevil.5Since the mortality is so high and there is no specific antidote, we suggest that a less toxic but equally effective agent should be sought to replace this lethal substance.1 Hackenberg U. Chronic ingestion by rats of standard diet treated with aluminium phosphide.
Very early recognition of coronary heart disease.
Authors: J R O'Brian
Journal: BMJ (1977)

These data show that a high prevalence of G-6-PD deficiency in Sardinian men is associated with duodenal ulcer and suggests that this deficiency may be a cofactor in the pathogenesis of the disease.This association is difficult to interpret and in any case our findings should be compared with data from other countries where the prevalence of G-6-PD deficiency is similar to that found in Sardinia.
The Vascular War of 1988: The Enemy Is Met
Authors: Christopher K. Zarins
Journal: JAMA (1989)

NUMEROUS skirmishes, battles, and wars relating to territorial rights of various specialties involved in treating patients with vascular disease have been waged over the years. These have involved issues of patient welfare, access, availability and cost of resources, economic interests of physicians and hospitals, and quality control. The current "vascular war of 1988" began smoldering among vascular surgeons and radiologists with the widespread introduction of transluminal balloon angioplasty for the treatment of peripheral vascular disease in the 1970s. It has burst into flames in some parts of the nation with the development and introduction of new, high-tech transluminal devices for the treatment of occlusive vascular lesions and now involves not only vascular surgeons and radiologists but also cardiologists. Although most of the new devices are not fully developed, tested, or proven, explosive media exposure of preliminary tests and the Star Wars magic of the word "laser" have led to high
Orders Not to Resuscitate
Authors: Mitchell T. Rabkin, Gerald Gillerman, Nancy R. Rice
Journal: New England Journal of Medicine (1976)

Medical opinions on the inappropriateness of cardiopulmonary resuscitation of certain patients are now openly discussed, as acknowledged by the New Jersey Supreme Court in its recent Quinlan decision. As early as 1974 the AMA proposed that decisions not to resuscitate be formally entered in patients' progress notes and communicated to all attending staff.* There has been little open discussion, however, of the process by which a decision not to resuscitate is formulated. Within a single institution, practices may vary among physicians, in part from the lack of a clearly articulated hospital policy.An apparent need for hospital definitions of the . . .
Librarians, Catalogers, Searchers
Authors: Diana Reinstein
Journal: JAMA (1988)

<h3>To the Editor.</h3> —I heartily applaud your recent MEDICAL NEWS &amp; PERSPECTIVES articles<sup>1,2</sup>about medical libraries. It's about time! Nevertheless, I feel compelled to point out some incorrect and misleading statements in your articles. First, to state that "a physician can obtain information without an intermediary" (referring to on-line literature searching) is something of an oversimplification. True, there are physicians and other health professionals who do their own searching, but they are by far the minority, as it is still a complex undertaking. Second, I think that the statement by Kent Mayfield, PhD, of the Medical Library Association must have been quoted out of context. Hospital libraries are certainly not moving "much more" slowly into the computer environment. In fact, many hospital libraries were among the first to become involved with on-line searching. It is true that most hospital libraries are not heavily involved in projects such as IAIMS,
Consensus Development Conference on Antipsychotic Drugs and Obesity and Diabetes
Authors: Leslie Citrome, Jan Volavka
Journal: Diabetes Care (2004)

The report from the Consensus Development Conference on Antipsychotic Drugs and Obesity and Diabetes Consensus Panel (1) contains valuable advice for the appropriate and prudent monitoring of patients who are at risk for type 2 diabetes. The recommendations made are similar to a prior consensus conference (2) and, if they are followed, will benefit our vulnerable patients by the early identification and treatment of metabolic disorders.

However, the report probably overreaches available evidence when suggesting that clinicians should consider prescribing one antipsychotic over another with the aim of avoiding diabetes. Although clear differences exist in liability for weight gain (and consequently dyslipidemias), quantifiable risk differences among …