tbuckley/cabot-search huggingface dataset:
AMINO ACID COMPOSITION AND ELECTROPHORETIC PROPERTIES OF HYPERTENSIN I
Authors: Leonard T. Skeggs, Walton H. Marsh, Joseph R. Kahn, Norman P. Shumway
Journal: The Journal of Experimental Medicine (1955)

A preparation of hypertensin I was purified by countercurrent distribution and was shown to migrate as a single component in starch blocks at pH 9.3 and 4.2. It had an isoelectric point of 7.7. Quantitative analysis by ion exchange column chromatography showed eight amino acids in approximately unimolar proportion: aspartic, proline, valine, isoleucine, leucine, tyrosine, phenylalanine, and arginine. There were in addition two moles of histidine.
Cigarette Smoking and Invasive Cervical Cancer
Authors: Louise A. Brinton
Journal: JAMA (1986)

A case-control study of 480 patients with invasive cervical cancer and 797 population controls, conducted in five geographic areas in the United States, included an evaluation of the relationship of several cigarette smoking variables to cervical cancer risk. Although smoking was correlated with both age at first intercourse and number of sexual partners, a significant smoking-related risk persisted for squamous cell carcinoma after adjustment for these factors (relative risk, 1.5). The risk of squamous cell cancers increased significantly with intensity and duration of smoking. Twofold excess risks were seen for those smoking 40 or more cigarettes per day and those smoking for 40 or more years. In addition, users of nonfilter cigarettes were at particularly high risk. Increased risks, however, were observed only among recent and continuous smokers. In contrast to squamous cell cancer, no relationship was observed between smoking and risk of adenocarcinoma or adenosquamous carcinoma (n = 63). These results suggest a causal relationship between cigarette smoking and invasive squamous cell cervical cancer, perhaps through a late-stage or promotional event, although the mechanisms of action require further elucidation.
Aboriginal children are still twice as likely to die as other young Australians
Authors: J. McCredie
Journal: BMJ (2008)

The death rate among children and adolescents from Aboriginal and other indigenous groups in Australia has fallen over the past decade, a report has found. However, indigenous people aged between 1 year and 20 years are still twice as likely as other Australians in this age group to die, it says.

The report highlights the scale of the challenge faced by Australian federal and state governments, which last year committed themselves to closing, within a generation, the 17 year gap in life expectancy between indigenous and non-indigenous Australians.

The push to …
The Apologie and Treatise of Ambroise Pare
Authors: H. Ellis
Journal: BMJ (2009)

I first read this brilliant translation in its year of publication, 1951. I had just passed my FRCS examination and was completing my two years of national service. I was enthralled. I have dipped into its pages many times over the years, and I have learnt much from my surgical hero.

Ambroise Pare (1510-90) trained as a barber surgeon and spent three or four years as a resident surgeon in that great repository of pathology, the Hotel-Dieu, in Paris. At the age of 26 he began his career in military surgery as a surgeon to the mareschal de Montejan, commander of the French infantry in the campaign in Turin.

This slim …
Dietary fibre and ketone bodies: reduced urinary 3-hydroxybutyrate excretion in diabetics on guar.
Authors: D J Jenkins, T D Hockaday, T M Wolever, R Nineham, D V Goff, P Haisman, R Charnock, R H Taylor, S Bacon
Journal: BMJ (1979)

Dietary fibre and ketone bodies: reduced urinary 3-hydroxybutyrate excretion in diabetics on guar Dietary fibre is known to modify carbohydrate absorption and metabolism in both normal and diabetic individuals.'-3Except for reports on the action of certain forms of fibre in reducing serum cholesterol concentrations,3 however, no attention has been given to other changes in lipid metabolism.Since urine testing for ketone bodies is still a major part of the clinical assessment of the diabetic, we have looked at the effect of guar gum on the output of 3-hydroxybutyric acid (3-OHB) in diabetic volunteers.If both 3-OHB and glucose outputs were reduced at the same time then this would suggest a general improvement in diabetic control rather than carbohydrate malabsorption.
Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging
Authors: Cuifang Zheng, Mingbin Zheng, Ping Gong, Dongxue Jia, Pengfei Zhang, Bihua Shi, Zonghai Sheng, Yifan Ma, Lintao Cai
Journal: Biomaterials (2012)
ACUTE AND CHRONIC ENTEROTOXIN ENTERITIS
Authors: Sherwyn E. Warren, Myron Jacobson, Jafar Mirany, John Van Prohaska
Journal: The Journal of Experimental Medicine (1964)

1. Dogs develop severe gastrointestinal symptoms in response to intraintestinal administration of staphylococcal enterotoxin. These symptoms are salivation, vomiting, and diarrhea. 2. Staphylococcal enterotoxin induces acute enteritis marked by edema, hyperemia, round cell infiltration, mucosal exudation, and destruction of intestinal villi. 3. Prolonged administration of enterotoxin into the lumen of the intestine produced thickening of the entire bowel wall, edema, dilatation of the lymphatics, and exaggeration of submucous lymphoid nodules. The hypertrophy of the lymphoid nodules is visible, in the gross, as enlarged longitudinal mucosal ridges. This abnormality is arranged in skip areas, not dissimilar to those observed in human regional enteritis. 4. Chronic enterotoxin enteritis is associated with mesenteric lymph node hypertrophy. 5. The intestinal mucosa shows minute ulcerations, loss of villi, submucous fibrosis, and evidence of chronic inflammation.
<i>Chlamydophila pneumoniae</i> Induces ICAM-1 Expression in Human Aortic Endothelial Cells via Protein Kinase C–Dependent Activation of Nuclear Factor-κB
Authors: Silvana A. Vielma, Gregor Krings, Maria F. Lopes-Virella
Journal: Circulation Research (2003)

Chlamydophila pneumoniae has an epidemiological link with atherosclerosis and acute cardiovascular events. One mechanism that may explain such a link is the increased expression of intracellular adhesion molecule-1 (ICAM-1) in C pneumoniae –infected endothelial cells. Upregulation of ICAM-1 by C pneumoniae is well recognized and has been extensively studied, but the signaling pathways involved are not yet defined. Because upregulation of ICAM-1 by cytokines and other stimuli has been shown to be mediated by either mitogen-activated protein kinase, protein kinase C (PKC), or nuclear factor-κB (NF-κB) pathways, we examined whether these pathways were involved in the ICAM-1 upregulation induced by C pneumoniae . Our data show a time-dependent phosphorylation of p44/p42 and SAPK/JNK pathways in C pneumoniae –infected cells. However, inhibition of the classic mitogen-activated protein kinase pathway using the PD98059 and U0126 inhibitors and inhibition of SAPK/JNK pathway did not suppress C pneumoniae –induced ICAM-1 expression. C pneumoniae also activates the NF-κB pathway at 30 minutes after infection. Treatment of human aortic endothelial cells (HAECs) with the NF-κB inhibitors BAY117085 and caffeic acid phenethyl ester led to a concentration-dependent inhibition of C pneumoniae –induced ICAM-1 upregulation. Finally, C pneumoniae –infected HAECs show membrane translocation of total PKC 30 minutes after cell infection. Calphostin C, a general PKC inhibitor, blocked both C pneumoniae –induced ICAM-1 expression and C pneumoniae –induced NF-κB translocation. In conclusion, we demonstrated that C pneumoniae –induced ICAM-1 expression in HAECs requires NF-κB and PKC activation and that NF-κB activation is PKC dependent.
LAPAROTOMY UNDER LOCAL ANESTHESIA ON A PATIENT, AGED SEVENTY-TWO.
Authors: R. L. IGEL
Journal: JAMA (1905)

I wish to report a very interesting case that came under my care July 31, 1905. <h3>Patient.</h3> —A woman, aged 72, was suffering from an ovarian cyst of seven years' standing, which had grown to such an extent as to fill the whole abdominal cavity. <h3>Examination.</h3> —I found her in terrible pain, resembling that of obstruction of the bowels. An enema was given, with no results, and I knew that cathartics would only increase the trouble. I therefore determined to relieve the bowel that I was sure was being obstructed from the pressure of the cyst by tapping the tumor. <h3>Operation,</h3> —She was taken to the hospital, a few blocks from her home and was prepared for operation. Chloroform and ether were contraindicated by her age and exhausted condition, so I began by injecting a small amount of a 4 per cent. solution of cocain three inches below the umbilicus,
Hepatotoxicity and the Oral Contraceptives
Authors: JAMES A. O'CONNOR
Journal: Annals of Internal Medicine (1977)

Comments1 January 1977Hepatotoxicity and the Oral ContraceptivesJAMES A. O'CONNOR, M.D., F.A.C.P., F.A.I.C.JAMES A. O'CONNOR, M.D., F.A.C.P., F.A.I.C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-1-118_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent editorial by Stauffer and Hill (1), "Systemic Contraceptives and Liver Tumors," we find repeated again a common misstatement that "both the synthetic estrogens and progesterones used in many of the oral contraceptive preparations are 17α-alkyl-substituted steroids" [italics added]. The facts are that no synthetic estrogen used in any contraceptive ever sold in United States and no synthetic progestogen used currently or during the past many years is a 17α-alkyl-substituted steroid.The editorial then goes on to enumerate many hepatotoxic effects reported as due to synthetic estrogens and progestogens, two classes of hormones that are...Reference1. STAUFFERHILL JR: Systemic contraceptives and liver tumors (editorial). Ann Intern Med 85:122-123, 1976 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES A. O'CONNOR, M.D., F.A.C.P., F.A.I.C.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHepatotoxicity and hepatic metabolism of available drugs: current problems and possible solutions in preclinical stages 1 January 1977Volume 86, Issue 1Page: 118-119KeywordsContraceptivesEstrogensHormonesLiverOral contraceptive therapyProgesteroneProgestogensSteroids ePublished: 1 December 2008 Issue Published: 1 January 1977 PDF downloadLoading ...
Intervention psychothérapeutique et structures familiales
Authors: G. Pankow
Journal: Psychotherapy and Psychosomatics (1972)

For nearly 20 years the author has based the analytical psychotherapy of psychoses on the body image and could point out that zones of destruction in the body image of psychotic patients correspond to zones of destruction in their family structures. Thus gaps in the family structure represent a danger for the treatment and even for prior questioning. The psychotherapeutic intervention which deals with family dynamics helps us to work more efficiently and to limit troubles in symbolic processes which characterize psychosis.
New forms for references.
Authors: E Huth
Journal: BMJ (1979)

Four major clinical journals have recently published the Vancouver Declaration, Uniform Requirements for Manu scripts Submitted to Biom?dical Journals.1-4 This document represents an agreement among several journal editors that manuscripts submitted to them for publication should be prepared in accordance with specific requirements. The agree ment further stipulates that the requirements about manuscripts stated in a journal's instructions to authors should not contradict any of the uniform requirements. The details of style in the Vancouver Declaration apply to manuscripts, and the co-operating journals are not required to use any of the style details as their publication style. Neverthe less, the editors of some of the co-operating journals have decided to use most, or all, of the manuscript style details for their pub lication styles. The Annals of Internal Medicine is taking that step. Beginning in our July 1979 issue we shall use the form of refer ences outlined in the Vancouver Declaration for all papers pub lished in the journal. (This is the form used for the references at the end of this paper.) In January 1980 other journals and Index Medicus will begin to use the new forms.
Survival in subgroups of patients with left main coronary artery disease. Veterans Administration Cooperative Study of Surgery for Coronary Arterial Occlusive Disease.
Authors: T Takaro, P Peduzzi, K M Detre, H N Hultgren, M L Murphy, J van der Bel-Kahn, J Thomsen, W R Meadows
Journal: Circulation (1982)

This report presents the 42-month survival experience of 91 patients with a significant lesion of the left main coronary artery in the Veterans Administration Cooperative Study of Coronary Bypass Surgery. Survival in surgical patients was significantly better than that in the medical group (p = 0.016), even after adjustments were made for two important differences in baseline characteristics--duration of angina and high risk by angiographic criteria--between the two groups (p = 0.019). Subgroups based on severity of left main stenosis and on left ventricular (LV) function showed significant trends in favor of surgery in patients with more than 75% left main stenosis and in those with abnormal LV function. A similar but nonsignificant trend was seen in the two subgroups with 50-75% stenosis or with normal LV function. The surgical benefits were not significantly different between the categories of the subgroups defined separately by stenosis and LV function. Low-, middle- and high-risk subgroups based on four noninvasive clinical predictors also showed significantly improved survival with surgery in the high-risk group. The low-risk groups showed a slight, nonsignificant disadvantage with surgical treatment. These data support the view that patients with left main disease are not a homogeneous group. High- and low-risk subgroups with different outcomes and responses to treatment can be delineated by angiographic or clinical criteria. For most patients with left main disease, coronary artery bypass grafting offers improved longevity.
Detection of complement activation using monoclonal antibodies against C3d
Authors: Joshua M. Thurman, Liudmila Kulik, Heather Orth, Maria Wong, Brandon Renner, Siranush A. Sargsyan, Lynne M. Mitchell, Dennis E. Hourcade, Jonathan P. Hannan, James M. Kovacs, Beth Coughlin, Alex S. Woodell, Matthew C. Pickering, Bärbel Rohrer, V. Michael Holers
Journal: Journal of Clinical Investigation (2013)

During complement activation the C3 protein is cleaved, and C3 activation fragments are covalently fixed to tissues. Tissue-bound C3 fragments are a durable biomarker of tissue inflammation, and these fragments have been exploited as addressable binding ligands for targeted therapeutics and diagnostic agents. We have generated cross-reactive murine monoclonal antibodies against human and mouse C3d, the final C3 degradation fragment generated during complement activation. We developed 3 monoclonal antibodies (3d8b, 3d9a, and 3d29) that preferentially bind to the iC3b, C3dg, and C3d fragments in solution, but do not bind to intact C3 or C3b. The same 3 clones also bind to tissue-bound C3 activation fragments when injected systemically. Using mouse models of renal and ocular disease, we confirmed that, following systemic injection, the antibodies accumulated at sites of C3 fragment deposition within the glomerulus, the renal tubulointerstitium, and the posterior pole of the eye. To detect antibodies bound within the eye, we used optical imaging and observed accumulation of the antibodies within retinal lesions in a model of choroidal neovascularization (CNV). Our results demonstrate that imaging methods that use these antibodies may provide a sensitive means of detecting and monitoring complement activation-associated tissue inflammation.
Epithelial distribution of a myelomonocytic antigen L1 in relation to cutaneous malignancies and melanocytic naevi
Authors: T.-O. GABRIELSEN, P. BRANDTZAEG, P.S. HOEL, I. DALE
Journal: British Journal of Dermatology (1988)

Journal Article Epithelial distribution of a myelomonocytic antigen L1 in relation to cutaneous malignancies and melanocytic naevi Get access T.‐Ø. GABRIELSEN, T.‐Ø. GABRIELSEN Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, The National Hospital, Rikshospitalet, Oslo, Norway Dr T.‐Ø. Gabrielsen, LIIPAT, Rikshospitalet, 0027 Oslo 1, Norway. Search for other works by this author on: Oxford Academic Google Scholar P. BRANDTZAEG, P. BRANDTZAEG Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, The National Hospital, Rikshospitalet, Oslo, Norway Search for other works by this author on: Oxford Academic Google Scholar P.S. HOEL, P.S. HOEL Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, The National Hospital, Rikshospitalet, Oslo, Norway Search for other works by this author on: Oxford Academic Google Scholar I. DALE I. DALE Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, The National Hospital, Rikshospitalet, Oslo, Norway Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 118, Issue 1, 1 January 1988, Pages 59–67, https://doi.org/10.1111/j.1365-2133.1988.tb01750.x Published: 01 January 1988
A YELLOW FEVER VACCINE
Authors: E. Hindle
Journal: BMJ (1928)

A YELLOW FEVER -VACCINB.t Tim AM"_ intradermal inoculation and to prevent a severe septic- aemia, but insufficient to prevent a local infection of the uterus; just as every grade of susceptibility to scarlet fever or tonsillitis is well recognized.No skin tests on women actually suffering from puerperal fever have been made, but it is hoped to undertake these as opportunities arise.A-fatal case of S. pyogenes septic- aemia in a man, recently tested, proved vigorously toxin- sensitive.In a few instances toxins prepared from strains of S. pyogenes from puerperal sources have been tested simultaneously with the standard scarlatinal toxin, and so far with the same results, thus supporting Okell's findings.It is realized that one hundred cases are insufficient to afford conclusive proof of the significance of the toxin test.The investigation is being pursued, therefore, and it is hoped soon to have further evidence.Finally, it may be stated that the possibilities of the toxin-sensitive test as a guide to preventive treatment against S. pyogenes infections have not been overlooked.If the conclusions reached receive support, the time may come when prophylactic immunization of toxin-sensitive women will be practised as a routine.But the indications for such immunization, the optimum time in relation to labour, the means employed-by active dosage with toxin or by passive iLmmullization with antitoxic serumii-have yet to be studied. Summary.1. Of iCo pregnant women, 27 were sensitive to a dose of 1/5 c.cm. of a dilution of 1 in 1,000 scarlatinal toxin injected intradermally.
INTRAAORTIC BALLOON PUMP COUNTERPULSATION AUGMENTS THE BENEFITS OF REPERFUSION ON LEFT VENTRICULAR MECHANOERGETICS - EXPERIMENTAL STUDY
Authors: Konstantinos Malliaras, Nikolaos Diakos, Iraklis Pozios, Eleni Tseliou, Dimitrios Koudoumas, Lampros Katsaros, Michalis Bonios, Stella Vakrou, Emmanouil Konstantakis, John Terrovitis, John N. Nanas
Journal: Journal of the American College of Cardiology (2010)
Prurigo Pigmentosa After Bariatric Surgery
Authors: Mustafa Abbass, Firass Abiad, Ossama Abbas
Journal: JAMA Dermatology (2015)

OBSERVATION Prurigo Pigmentosa After Bariatric Surgery2][3] The lesions then resolve with residual hyperpigmentation.The pathogenesis of PP is not completely clear.2][3] Herein we report the first case to our knowledge of PP occurring after bariatric surgery, which provides further evidence of a possible role of ketosis in PP pathogenesis.
Prednisolone absorption in acute colitis.
Authors: P R Elliott, J Powell-Tuck, P E Gillespie, J M Laidlow, J E Lennard-Jones, J English, J Chakraborty, V Marks
Journal: Gut (1980)

Peak plasma levels were reduced after an oral dose of 40 mg prednisolone in six patients with severe acute colitis as compared with six normal subjects, though total absorption appeared to be similar; the findings suggest that prednisolone absorption was delayed in acute colitis. A dilutional fall in plasma albumin was observed in normal subjects and in the patients after 40 mg prednisolone by mouth.
Plasma methionine enkephalin concentration and prognosis in primary biliary cirrhosis.
Authors: J. R. Thornton, M. S. Losowsky
Journal: BMJ (1988)

Maloprim by the patient had near fatal results.Pyrimethamine was taken by all four patients, suggesting that this may have been the toxic agent.Previous workers assumed that the sulphonamide component of Fansidar was responsible for the pulmonary toxicity.'In one report a lymphocyte trans- formation test yielded positive results in the presence of sulfadoxine but also with pyrimethamine, perhaps suggesting that non-specific cell activation had occurred.3We were unable to show lymphocyte activation with either dapsone or pyrimethamine, but this was assessed in only one patient and then only after she had recovered and taken steroids.Dapsone, the other constituent of Maloprim, is structurally related to the sulphonamides.Nevertheless, despite its widespread use it has not been reported to cause pulmonary eosinophilia.Similarly there are no reports of pul- monary toxicity with chloroquine.Three further cases of pulmonary eosinophilia, one confirmed by lung biopsy, have been reported to Wellcome Research Laboratories in patients who had taken Maloprim, and two cases of pulmonary toxicity with systemic features have been reported in patients who had taken pyri- methamine-chloroquine (L Maskell, personal communication).We therefore believe that pyrimethamine may cause pulmonary eosinophilia.We thank Dr W D Riding and Dr J 0 Hunter for permission to report cases 3 and 4; Mr M V Braimbridge for obtaining the lung biopsy specimens; Dr L Delgardo for performing the lymphocyte transformation test; and Dr D B A Hutchinson, Wellcome Research Laboratories, for supplying Maloprim.Daraclor is no longer available in the United Kingdom.
Medical Care of the Sick Newborn
Authors: Leslie L. Barton
Journal: JAMA (1977)

The second edition of the<i>Medical Care of the Sick Newborn</i>is a lucid, up-to-date, yet manageable volume devoted, in actuality, to the perinatal period. Drs Pierog and Ferrara present us with guidelines for the diagnosis and treatment of the newborn infant. This is not an exhaustive textbook; rather, it is, as intended, a stimulus for further literary and medical research in the field of neonatology. The book is divided into three segments. Part 1 delineates the organization of a newborn service. Included in this section is an objective overview of the transport of the high-risk neonate, as well as a timely chapter on auditing and evaluating neonatal services. Part 2 is devoted to the care of the normal as well as the ill neonate. The sections devoted to abnormal signs and symptoms such as respiratory distress, cyanosis, and jaundice, presented mainly in outline form, are outstanding. Part 3 includes
(20) Junctional epidermolysis bullosa
Authors: W.J. Cunliffe, J.F.B. Norris
Journal: British Journal of Dermatology (1987)

Journal Article (20) Junctional epidermolysis bullosa Get access W.J. Cunliffe, W.J. Cunliffe The General Infirmary at Leeds Search for other works by this author on: Oxford Academic Google Scholar J.F.B. Norris J.F.B. Norris The General Infirmary at Leeds Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 117, Issue s32, 1 June 1987, Pages 67–68, https://doi.org/10.1111/j.1365-2133.1987.tb12060.x Published: 01 June 1987